PMC8716518__F11 Extracellular vesicles (EVs) isolated from key time points after burn injury induce differential gene expressions, predicted to significantly impact immune functions in macrophages in vitro RP2 NOA1 TOX PMC8165385__F1 Methylene Blue Application to Lessen Pain: Its Analgesic Effect and Mechanism BDNF SIRT1 CP PMC9210989__F3 Significance of PAK4 in signaling and clinicopathology: A review TH EGF BAD HGF TRADD GEM EGFR RELB PAK4 GIP CDC42 PMC4968117__F1 Epidermal growth factor receptor and its downstream signaling pathway EGF EGFR PTEN MTOR PMC7683543__F5 Canonical pathway enrichment analysis identifies immune response classical complement pathway as the ones most enriched in PVEC co-cultured with NPC C4A CR1 PMC7890860__F4 Signalling pathway and key factors which regulated the mitochondrial energy metabolism in MSCs SIRT1 UCP2 SIRT3 PMC7905242__F4 “瓜蒌-甘草”药对化学成分（）-靶点蛋白（）-信号通路（）网络Chemical components ()-target protein ()-signal pathway () network of "Trichosanthis fructus-Glycyrrhizae radix et rhizoma" drug pair RARA BTK PLAT SHBG CYP2C19 F2 F3 LDLR IL2 ELANE ABCG2 NR1A2 PMC10216619__F4 Possible neurological and mental COVID-19 outcomes related to the angiotensin-converting enzyme 2/Mas/brain-derived neurotrophic factor (ACE2\Mas\BDNF) signaling pathway occupation by SARS-CoV-2 ACE2 BDNF IL1B TMPRSS2 BAX PMC10216619__F2 Adiponectin paradox and its related pathways during COVID-19 infection HMGB1 ACE2 TMPRSS2 PMC4456163__F1 Putative Regulatory Factors Associated with Intramuscular Fat Content MT3 PMC4714843__F7 Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi EGR1 CCL11 SPRY4 IL13 LIF SMAD6 BMP7 CXCL2 IL6 IL5 ID1 ID3 SPRY2 PMC8400885__F10 Benzoic Acid and Its Hydroxylated Derivatives Suppress Early Blight of Tomato (Alternaria solani) via the Induction of Salicylic Acid Biosynthesis and Enzymatic and Nonenzymatic Antioxidant Defense Machinery PMC8950247__F3 Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway Might Be Associated with Diabetic Ischemic Heart Disease HMGB1 IL6 SFTPB CNTF ITGAM LMO4 ERAP1 AGER NFKB1 RELA PIAS1 PTPRE IL6ST JAK1 PMC8395431__F1 TNFA and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer? TRADD REL TRAF2 FADD PMC9408851__F3 Function of N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Negative Regulator in Tumor Cell Metastasis MYB NDRG2 SOCS1 STAT3 PMC11957794__F3 Different types of COL remodeling-mediated signaling pathways DDR1 ECD KEAP1 CXCL5 STAT3 PMC8313969__F2 Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment SMAD2 EGFR GSK3B SMAD4 CCL5 PTEN CCL2 HIF1A MTOR IL6R FGFR2 STAT3 PMC4360066__F6 T-cell activation pathway regulating six key activation genes STAT1 TAGAP FYN BCL10 NFKB1 DOK1 IFNG PMC12078210__F4 IL-21 promotes the formation and maintenance of germinal centers and plays a decisive role in the differentiation of GC-derived B cells into plasma cells BCR PAX5 GC PMC12078210__F2 Pathways of Allogeneic Antigen Recognition and the Impact of IL-21 on DCs CCR7 PMC4213195__F5 Schematic model of Wnt- and SHH pathways working interdependently in GBM based upon observations in this study SHH SMO CSNK1A1 PMC2238877__F4 PharmGKB Irinotecan Pathway UGT1A3 UGT1A9 CES2 CES1 NFKB1 ABCG2 BCHE ABCC2 ABCB1 UGT1A1 TDP1 PMC6006338__F5 Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids STAT1 STAT2 IRF9 PMC7946814__F1 Sclerostin: an inhibitor of canonical Wnt signaling pathway APC LRP5 LRP6 PMC11664622__F1 Hepatitis B virus immune tolerance mechanism IRF3 CTLA4 TNF PMC3151419__F6 Regulation of the mTOR signaling pathway by insulin and growth factors TSC2 RICTOR TSC1 IGF1 PTEN MTOR DEPTOR IRS1 RHEB MLST8 PMC11664622__F2 Pathogenesis of liver cancer CDKN1A SUFU APC PTCH1 AXIN1 LRP5 BCL2 LRP6 SMO ADAM10 PMC3151419__F7 Regulation of mTOR pathway by Sestrins TSC2 TSC1 SESN1 SESN2 RHEB PMC4031321__F1 HIV induction by PKC activators and HDAC and BET inhibitors: NFKB is sequestered in the cytoplasm by IKB CDK9 BRD2 TF BRD4 PMC7677305__F4 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders TBK1 CGAS IRF3 PMC6117983__F4 Platelet hyperreactivity in type 2 diabetes mellitus VASP COX1 PGR IRS1 PMC6222618__F1 Post-squalene cholesterol biosynthetic pathway EBP SC5D DHCR24 PMC3677135__F6 The canonical Shh signaling pathway SUFU SHH SMO PMC3677135__F7 Wnt signaling pathways APC GSK3B LRP5 PTK7 LRP6 RYK RHO PMC3677135__F8 Intracellular mechanisms underlying Wnt-induced axon guidance RYK CELSR3 PMC11780521__F5 Metabolic reprogramming in fibrogenic HSCs activation in chronic liver diseases RARB PCSK9 TLR4 ACAT1 NR1B3 EBP LRP5 LDLR COL1A1 XBP1 ADAM17 THRA PMC9209730__F3 New Sights Into Long Non-Coding RNA LINC01133 in Cancer GDF15 SMAD2 MSC FOXP2 PMC3577986__F6 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy APP RGS1 LPP KNG1 YWHAG PMC8042693__F11 PPI network ADH1C HEL-S-117 UGT1A7 PMC3577986__F4 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy IL10 TNLG1B ATG16L1 LRRK2 ITLN1 IRGM NKX2-3 ZNF365 SLC26A5 IFNG STAT3 PMC9139342__F9 Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer TSC2 EGF TSC1 EGFR ARHA RAC1 HIF1A MTOR RHEB PMC3577986__F1 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy IL2 IL10 TNLG2B BLK HDAC1 PTPN22 CBL HEL-S-125m FCGR3A SCUBE1 HNF4A STK16 ERBB2 STAT4 LYN TREX1 BCL2 TYK2 SELP REL CD226 PPARG DNASE1 TGFBI PDCD1 PMC3677135__F2 Shh and Wnts guide commissural axons in the vertebrate spinal cord HHIP BOC SHH SMO PMC5991413__F1 Unsolved mysteries: How does lipid peroxidation cause ferroptosis? GPX4 LPCAT3 FACL4 PMC3821792__F2 TLR-4 signaling pathway.Notes: TLR-4/MD-2 complex homodimerization activates the MyD88-dependent pathway and TRIF-dependent pathway IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 IFNG PMC9405250__F11 Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies KEAP1 POR HMOX1 TXN BACH1 PMC8573346__F8 Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway NLRP3 COX2 IL16 GSDMD PMC1134985__F3 Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? CDS1 WEE1 SI CHP1 PMC3779382__F6 Therapeutic modulation of EBV infection and associated signaling pathways BCR MDM2 MTOR PMC11011165__F1 Inappropriate STAT activation in cancer cells BCR EGFR SRC PMC8067185__F1 Induction of EMT by targeting EMT-related genes via activation of the growth factor signaling pathway in pancreatic cancer HDAC2 MSX2 CDH2 S100A4 HDAC1 PMC3179879__F5 Abrin (ABR)-triggered apoptosis ROS1 ABRA BAX PMC4041745__F5 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome ROCK2 LIMK2 LIMK1 PLAUR PLG HEL-S-28 VAV1 GSK3B VEGFA SHE DOCK1 PTEN RAC1 EIF4E HRAS CRK EIF4G1 TRIO CDC42 PMC4041745__F6 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome ROCK2 LIMK2 EGFR ARHA RHO GRB7 RAI1 TIAM1 FER PAK1 FYN RAP1A CDC42 PMC3779382__F2 EBV-mediated oncogenic signaling pathway activation in EBV-positive diffuse large B-cell lymphoma of the elderly TRADD TRAF5 CDK2 TRAF1 TRAF3 TRAF2 PMC3115623__F5 Major intracellular signal transduction pathways for CRF1 and CRF2 receptors GRB2 SRC BDNF PMC3617635__F6 CLL-induced Rho GTPase signaling defects in T cells that suppress LFA-1 activation signaling and migration and how this is reversible with lenalidomide ARHA RAC1 CDC42 PMC5884250__F2 Proposed molecular mechanism for maintenance of MSC stemness by cell–cell adhesion through cadherin SRC CDH2 PMC4041745__F4 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome F2 TRPC6 ARHA TRPC3 BDKRB2 PMC9126990__F1 Biochemical genesis of enzymatic and non-enzymatic post-translational modifications ACLY HEL107 EHHADH ASL GLS PMC3419804__F1 Autophagy, Myocardial Protection and the Metabolic Syndrome HEL-S-62p TSC2 ULK1 TSC1 PTEN IRS1 RHEB PMC5710380__F1 Mast cells and their receptors MRGPRX2 TLR4 PMC11840356__F1 Mitochondrial Dysfunction and Pathways of Apoptosis in Traumatic Brain Injury (TBI) BAD FADD BAX PMC7998465__F7 Molecular regulatory mechanism underlying UA’s anticancer activity in NSCLC cells, and UA’s inhibition of the EGFR/JAK2/STAT3 signaling pathway and PD-L1 EGF EGFR STAT3 PMC4284625__F1 Genetic pathways, prevention, and treatment of sporadic colorectal cancer BRAF APC BAX PMC7716721__F4 SFN-induced ferroptosis pathway GPX4 SFN SLC7A11 PMC12185281__F3 Pathophysiological mechanisms of insulin resistance in the vasculature PDK2 INS PMC4879750__F1 TGFB signaling in fibroblasts SMAD4 NOX4 PMC6087706__F2 Signaling cascades for YAP/TAZ regulation TEAD3 SRC TEAD4 LATS1 MOB1A MOBKL1A LATS2 LIMD1 TEAD2 PMC4916901__F1 Link between DNA damage and transcription, and pathway of DSB-induced transcriptional repression RNF168 PRC1 RNF8 ATM PMC6366666__F1 TRAIL pathway targeting therapeutics FADD BAX PMC6211039__F2 Unfolded protein response pathways ATF4 EIF2A TRAF2 PMC8233907__F9 Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness CCNB1 MDM2 CCND1 CDK4 PTEN CDC2 BAX PMC6060268__F4 Overlapping actions of metformin and rapamycin EIF4E RPS6 MTOR EIF4B PMC8858883__AF1 Puerarin specifically disrupts osteoclast activation via blocking integrinB3 Pyk2/Src/Cbl signaling pathway SRC JUN PMC4465126__F7 Proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and nitric oxide (NO•) generation in PAH NOX4 STAR CYP11B2 PMC8307022__F1 Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer TSC2 TSC1 GSK3B PTEN PMC3814228__F1 Schematic diagram of the adiponectin-AMPK pathway in glomerular cells ADIPOR1 ADIPOR2 USF1 NOX4 PMC5522315__F3 Epithelial-to-mesenchymal transition in the development of endometriosis SOX2 SMAD2 APC GSK3B SMAD4 PMC3575670__F5 Precursor of myostatin is promyostatin and consists of a propeptide that binds to myostatin noncovalently to form an inactive complex SMAD2 SMAD4 PMC10917964__F3 Schematic diagram illustrating the promotion of bone formation by incorporating Sr2+ on the surface of titanium-based materials SP2 NFATC1 MMP9 PMC5069446__F2 Nutrients-mTOR-miRNA signaling in skeletal myogenesis MDM2 DROSHA ID1 IRS1 PMC6210148__F1 Topoisomerase 1 reaction and inhibitors SSB PARP1 TDP1 PMC5954027__F1 Selective and non-selective autophagy in CD4 T cells upon T cell receptor (TCR) activation ULK1 ATG101 ATG10 MTOR PMC6186311__F5 Beneficial effect of RC on hepatic glucose and lipid metabolism signalling pathways TG NR1C1 PMC11626780__F5 Immunosuppressive pathways involving tryptophan IDO1 TDO2 SLC36A4 PMC11626780__F6 Intracellular metabolic pathways of BCAAs and the mTORC1 signaling pathway RPS6KB1 ULK1 POLDIP3 TFEB BCAT1 HIF1A RHEB PMC11626780__F3 Glutamine interconversions and metabolic pathways PSAT1 ASNS PRODH PSPH PMC11626780__F4 Urea synthesis pathway involving arginine and PRMT-mediated FLT3 arginine methylation KDM4C GLDC FLT3 ASS1 ASL PMC4681406__F7 Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche through a Unique Signal Transduction Pathway - An Approach for Treating Bone Disease in Diabetes ADIPOR1 MSC MMP9 SMAD1 DKFZp781O1323 APPL1 PMC7068130__F8 Molecular Mechanism of Loss of Function of TLR9 Might Play a Major Role for NPC Susceptibility in Specific Ethnic Groups of NE IndiaSome populations, called “mongoloids,” show a significantly higher incidence for NPC PLSCR1 DGIC PRDM16 TLR9 UCP1 PMC2691147__F1 Hh signalling—a simplified model SUFU PTCH1 SMO PMC11726638__F9 Diagram encapsulates our hypothesis that cytidine/uridine monophosphate kinase 2 (CMPK2) promotes the progression of allergic rhinitis by activating the NLRP3 inflammasome via the mitochondrial DNA (mtDNA)‐STING signalling pathway NLRP3 CGAS CMPK2 PMC3142679__F1 Virus reactivation: a panoramic view in human infections ATF2 MYC PMC3095455__F1 Schematic representation of the apoptosis signaling pathway that indicates existence of three distinct signaling modules in the apoptotic intrinsic pathway BAX PMC8088080__F6 Unraveling the molecular crosstalk between Atherosclerosis and COVID-19 comorbidity TLR4 CXCL8 TRAF6 CXCL3 CXCL2 MYD88 PMC3887612__F5 Tau signaling cascade in LPA induced neurite retraction in differentiated Neuro2a cells ARHA RHO LPA PMC5472377__F6 Pathway alterations diagram integrating gene mutations and copy number alterations to identify pathways altered in UC- and CD-associated CAC BRAF EGFR APC MYC SMAD4 PTEN RB1 MTOR CDKN2A FBXW7 FGFR2 CDK6 CCNE1 TSC2 NF1 PI3 TSC1 FGFR1 ATM ERBB2 CCND1 CDK4 PMC3840609__F5 Gonadotropin-releasing hormone (GnRH) signaling pathway containing genes that are represented in the Partial Correlation Information Theory (PCIT) network “growth at the onset of puberty” BTC MMP2 HEL-S-11 EGFR CDC42 PMC5665037__F2 Involvement of lncRNAs in the “adenoma-carcinoma sequence”, multi-step model of CRC pathogenesis EGF ZEB2 APC EGFR MDM2 PTEN MTOR PMC3425519__F2 Intracellular vascular endothelial growth factor (VEGF) signal transduction pathway BRAF GRB2 PTEN MTOR PMC4417610__F2 Summary of the HGF/c-Met signaling pathway HGF GRB2 SRC STAT3 PMC12043450__F4 Signaling pathways associated with GH treatment for DOR GHR GRB2 NOTCH1 MAPK1 MTOR BAX SIRT3 PMC6512360__F9 The type I immune response in M MMP10 TH GZMK CASP12 CTSK STAT2 IRF7 IRGM IRF8 TNF HIF1A IFNG STAT1 FAT10 NOS2 IFNGR1 IRF-1 CTSW CST7 PMC8546337__F1 Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application TBK1 CGAS CXCL10 GSK3B PMC5578105__F1 Ubiquitin signaling in both sub-pathways of nucleotide excision repair (NER), global genomic (GG-) and Transcription coupled NER (TC-NER), and double-strand break (DSB) repair MDC1 XPC RNF2 DDB2 RBX1 DDB1 CUL4A NEDD4 UVSSA CUL4B RNF168 RNF8 ATM PMC11721126__F1 The development of SARS-CoV-2 induced osteoarthritis EDN1 EDNRA EDNRB TNFSF11 TNF PMC7280757__F3 Complement Membrane Attack Complex NLRP3 IL16 VCAM1 SMURF2 RELA CCL20 RELB ZFYVE21 CCL5 GSDMD PMC5673544__F1 Tandem repeat variation near the HIC1 promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer XPC ERCC1 XPA SIRT1 PMC4657330__F8 Rac1 activation and Wnt synergistically enhance Beta-catenin transactivation in the canonical Wnt pathway APC GSK3B RAC1 PMC9453822__F2 Dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment CXCL12 CCL22 STAT3 PMC4081676__F1 Protective role and partial mechanism of peroxisome proliferator-activated receptor A in alcoholic liver disease FGF21 TGFB1 NR1C1 SIRT1 UCP3 UCP2 CD36 PMC7556029__F3 Molecular mechanisms of IL-36R induced tissue fibrosis NLRP3 CXCL1 CCL2 MYD88 IFNG PMC10532080__F8 Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/Beta-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer SOX2 GSK3B PMC2917731__F1 Intracellular signaling of FIP1L1/PDGFRA+ (F/P) cells IL5RA CCR3 PMC7522025__F1 Schematics of spiralian embryo, TGFB superfamily cassette and larval Capitella phenotypes NODAL SMAD1 DKFZp781O1323 PMC5642700__F1 Systems biology analysis of longitudinal functional response of endothelial cells to shear stress GPX4 CDKN2D HEL-S-97n GPX1 CCNH NOX4 GPX8 PROX1 HIF1A FOSL2 HEL-S-128m PRDX3 CDK7 CCND2 HEL-S-2a MNAT1 VCAM1 NFKB1 CDK2 HDAC2 CDK4 PMC3325226__F3 A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study HMGB1 IL18 TLR4 AHR PPARGC1A RELA MYC UGT1A1 CP PMC8819670__F1 Hippo pathway consists of distinct oncogenic and tumour suppressive modules TEAD3 NF2 TEAD4 ARHA LATS1 LPA MOB1A LATS2 TEAD2 PMC8819670__F2 YAP/TAZ fusion partners and associated cancers NUTM1 MAML2 CAMTA1 PMC5818424__F7 Hypothetical model for the pathogenesis of glucose intolerance and insulin resistance in TRIM31−/− mice NLRP3 TLR4 IL1B PMC3564490__F3 Proposed alternative pathway of feto-placental androgen synthesis from 17-hydroxypregnenolone HSD3B2 SRD5A2 POR HSD17B3 CYP17A1 PMC3109867__F1 Insulin/iGF-1 signaling pathway is conserved across phylogeny IGF1 PTEN SGK1 PMC9525429__F1 Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder CRY1 PER2 PER1 PMC5040753__F7 Proposed mechanism of mechanical stretch-induced VSMC hypertrophy demonstrates that the RhoA/ROCK pathway activation, calcineurin activation, NFAT nuclear translocation, and leptin synthesis are involved in this process HEL-S-62p ARHA RHO PMC2863124__F1 DNA damage and replication checkpoints in various organisms CDS1 ATM PMC5294813__F3 Functional network of the interferon signaling pathway by IPA IRF9 PIAS1 IRF-1 SOCS1 IFNG BAX PMC9132047__F9 Study on the Mechanism of Sancao Tiaowei Decoction in the Treatment of MNNG-Induced Precancerous Lesions of Gastric Carcinoma Through Hedgehog Signaling Pathway DHH IHH SUFU EGFR SHH SMO MTOR PMC4733656__F5 The Elizabeth River Story: A Case Study in Evolutionary Toxicology AHRR AHR CYP1B1 PMC6482218__F1 The role of molecular genetic markers in cellular stress response TSC22D3 IGF2 NR3C1 FKBP5 NR3C2 MBL2 BDNF PMC4947211__F1 Schematic presentation of gene network implicated in TLR signaling pathway TBK1 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 PMC3642686__F4 Schematic description of the MSR IRF7 ATF4 EIF2A IRF3 TRAF2 XBP1 PMC2258669__F3 Enzymatic reactions and assays HPR CP HEL-S-162eP PMC6202076__F0 Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NFKB signaling pathway IKBKB NFKBIA CREBBP EP300 CDK2 NFKB1 RELA MYC PMC2258669__F1 Genomic and functional context of glycerate kinase enzymes in bacteria HP STUM HPR PMC5330810__F1 Inference of Cancer Mechanisms through Computational Systems Analysis GMPR ADA APRT PMC3997009__F1 Routes of presentation of viral peptides on DCs CD40 CD80 PMC8012550__F4 Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome PIK3CD FGF21 ASAP1 PRKCZ CTSS PPP3CA TUBB6 PPP3CC INS FGF8 CTNNA3 RILP ATP6V1C1 ATP6V1C2 MAP2K6 SPHK2 PDPK1 ITGA2 PRKCA LILRB5 MAPK12 GRIN1 MARCO CYLD PIKFYVE CD209 FGF19 AMPH MS4A2 FCGR2B IFNGR1 CTSK DOCK1 RAC1 IL5 CRK IKBKB ITGAM RAB5C CSF1 SHC1 HEL-S-81p NCF2 PMC5642700__F4 Higher-resolution version of with gene target names visible HIF1A FYN CSF2 ADM LAMC2 NOB1 CTSL NAMPT DUSP4 CTSK RSAD2 TUBB FOS VCAN LTB VEGFA ATF3 ENG CEBPA TNF UHRF2 PTHLH FOXO1 AURKB RXRA GNA11 APOB PLTP MUC4 EGR2 CHKA BIK KLF4 GFER KLF2 XPA MC1R ERCC2 BLMH LAT TF CXCL1 VASP NOX4 TEAD4 RARB NR1B3 JUN EGR1 IGF2 STAT3 PMC4887335__F1 Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes TRADD CYLD FADD MLKL TAB3 PMC5617345__F1 IGF-1R/AKT pathway determines cell fate in response to p53 PML PTMS IGF1R PMC5617345__F2 IGF-1R/AKT pathway determines cell fate in response to p53 IGF1R IGF1 MDM2 PTEN PMC5617345__F3 IGF-1R/AKT pathway determines cell fate in response to p53 IGF1R IGF1 GSK3B MDM2 PMC7404121__F2 Synergistic regulation mechanisms of leaf angle by phytohormones in rice CS BRD2 PMC4891268__F2 Cell-cycle entry regulated by a network of protein regulators TSC2 TSC1 CDK4 MTOR CDK6 PMC4466452__F1 Identified molecular targets involved in ELFEF-induced enhancement of adult hippocampal neurogenesis and osteogenesis RUNX2 MSC PMC6099685__F7 The potential pathway underlying the anticancer activity of CK in human HCC cells EIF2A STAT3 PMC2814453__F1 Coupling between Akt-mediated cellular energy metabolism, cell survival and proliferation TSC2 TSC1 PTEN RHEB PMC8538975__F4 Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed CSF3 TNFRSF6B CSF3R IL1R2 IFNGR2 LY96 CSF2RB PPBP TNFRSF13C TLR3 TICAM1 BMP4 IFNG TLR8 RIPK1 IL18 TLR7 TLR4 AMH CCR10 CRLF2 BIRC3 IFNGR1 TRAF2 PMC7677787__F2 Lysosomes function as an intracellular signal transduction platform TSC2 TSC1 GRB2 RHEB CBL PMC7432591__F2 Major signalling pathways associated with sarcopenia and peripheral arterial disease (PAD) IGF1 CRP MTOR STAT3 PMC3205276__F1 Biosynthetic pathway of sphingolipids consisting of free long chain bases (top row), which are N-acylated by several CerS enzymes to form dihydroceramides (upper row of octagons) CERS3 LASS1 CERS5 GAL CERK SMS CERS2 PMC3323831__F1 TLR signalling CD14 TLR5 TLR9 IRF7 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 FADD MAL PMC8212127__F2 Insulin-Like Growth Factor Pathway and the Thyroid PI3 IRS4 GRB2 IRS1 PMC8212127__F3 Insulin-Like Growth Factor Pathway and the Thyroid IRS4 MDM2 IRS1 PMC3965270__F8 Integration of L-R Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2 DAAM2 GPC3 NODAL PITX2 CDH2 PMC8212127__F4 Insulin-Like Growth Factor Pathway and the Thyroid IGF1 CD34 CD40 PMC8866957__F2 Glimpse of Programmed Cell Death Among Bacteria, Animals, and Plants GPX4 PURA RIPK3 NRG1 CYB POR ZAR1 BAX PMC3421022__F1 The prolactin signaling network in NetSlim PIK3R1 SOCS2 MAPK9 SOCS3 MAPK8 FLNA MAPK3 MYC MAPK14 TEC STAT1 SRC MAPK1 NOS2 FOS HRAS IRS1 PAK1 GRB2 MTOR RPS6 YWHAG JUN RAC1 ITGB1 HEL-S-130P PRL HEL-S-69p CBL CASP3 SIRPA NEK3 MAP2K1 CISH GAB2 NFKB1 PRLR RELA ZAP70 PIK3CA PPIB JAK1 RAF1 SOS1 HEL-S-93 SHC1 PXN AGAP2 SOCS1 PIK3R2 PMC5597488__F5 Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder TH CA3 DRD1 DRD2 BDNF DRD4 PMC6295076__F7 Hypothesied pathway showing the inhibitory mechanism of cyclin G2 on Wnt/Beta-catenin signaling through Dpr1 APC GSK3B CCNG2 PMC2659402__F3 Interleukin-31 acts through three signaling pathways: Jak/STAT pathway, PI3K/AKT pathway and MAPK pathway GRB2 JAK1 OSMR STAT3 PMC3418163__F1 The two enzymatic pathways generating inorganic phosphate (Pi) as a result of LPA degradation LPA HEL-S-5 PMC9436575__F6 Preventive Electroacupuncture Alleviates Oxidative Stress and Inflammation via Keap1/Nrf2/HO-1 Pathway in Rats with Cyclophosphamide-Induced Premature Ovarian Insufficiency MAF KEAP1 IL6 TNF PMC8260517__F2 Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities LATS1 MTOR LATS2 PMC5559826__F2 Downregulated genes involved in the insulin signaling pathway in response to the sugar-only diet KL BAD POR PMC5378352__F6 All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma RARA RARB FLT1 KDR BCL2 PMC6406849__F3 LRRFIP1/GCF2 binds to exogenous and endogenous nucleic acids and activates type 1 interferon and pro-inflammatory cytokine responses IRF3 MYD88 PMC8012063__F4 Status-dependent regulation of Kyoto Encyclopedia of Genes and Genomes pathway hsa050160 Alzheimer’s disease at the cross-tissue level SNCA HEL70 BAD CASP12 UCP1 GSK3B TNF CASP3 TBP APAF1 HTT LPL APP CASP9 REST SIN3A SP1 BDNF POC1A BPI FADD APOE TAF4 PMC4555477__F1 Some sphingolipid fundamentals LPP CERK HEL-S-5 PMC4411553__F4 Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus IL1A ITGB3 ITGA2B PMC4580488__F10 A schematic diagram showing the proposed signaling pathway underlying the regulation of ovarian cancer progression by HBEGF/EGFR/YAP/HBEGF and NRG1/ERBB3/YAP/NRG1positive feedback autocrine loops YAP1 ERBB3 EGFR NRG2 HBEGF NRG1 PMC5636111__F4 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia MAPK8 EGFR PPP3CC TCF7L2 FZD4 PDE1A ADCY3 PRKACG PLCB1 CALM1 PLCB2 WNT3 CREBBP EP300 JUN PMC5636111__F5 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia IL1A TRAF6 HRAS CRK FOXO1 PRKACG GABARAPL2 HOMER2 PLA2G4B SETD7 RASGRF1 GNAI3 GRIN2B PIK3CA ADCY5 GNAO1 MAPK11 FGF14 GRM6 RPS6KA2 CDC42 AKT3 PMC5094186__F1 (1) Nicotine binds to the nicotinic acetylcholine receptor, causing a conformational change that opens the receptor's ion channel and allowing entry of Ca2+ and Na+ BACE1 NRG3 EGF SRC MTOR PMC10218397__F9 TASE and thymol supplementation in neuronal differentiation and outgrowth effect NAGK MAP2 BDNF PMC9561135__F10 Gut-lung axis: Gut microbiota changes associated with pulmonary fibrosis in mouse models induced by bleomycin COL3A1 BLM SMAD2 TGFBR1 TGFBR2 TNF COL1A1 BAX PMC5746105__F17 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury EGF FACL4 GEM BTG3 NOX4 CD83 TFRC PRKCSH WNK4 YBX3 CLU FGF9 CHEK2 SCRN3 KL HEL-S-108 AGA A4GALT CUBN CYLD ARG2 CXADR VWF GLYCTK DCXR CAD EAF2 PSMB8 CALY FASN CTH KIT DPYD PLAUR CFB FOS ARHA TNF NFKBIA CCL20 PMC3660250__F8 Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3B, Neurotrophin-3 and CREB Signaling IGF1R IGF1 PLG IGF2 GSK3B PMC3807000__F2 Autophagy-related common pathway in neurodevelopmental disorders NF1 TSC2 TSC1 PTEN MTOR PMC3834144__F8 Schematic summary of OPRM1 differential signal pathways upon acute and chronic morphine administration OPRM1 SRC RAF1 PMC9040700__F2 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons STAT1 NLRP3 ACE2 PMC9040700__F1 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons HMGB1 TLR4 MYD88 MTOR PMC8518784__F9 Curcumin analog GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circular RNA zinc finger protein 83/microRNA‐324‐5p/cyclin‐dependent kinase 16 axis PCTK1 STAT3 PMC11212332__F7 Characterisation of sRNAs enriched in outer membrane vesicles of pathogenic Flavobacterium psychrophilum causing Bacterial Cold Water Disease in rainbow trout SOCS3 EEA1 SOCS1 PMC3616967__F4 Proposed model for iAs-induced birth defects via the GR pathway CASP3 NFKBIA SMAD2 RELA VHL NR3C1 CCND1 BCL2 RB1 NOS2 PXN STAT3 PMC7222031__F2 PVR’s role in immunomodulation CD96 HEL-S-92n TIGIT NECTIN2 PMC2810629__F1 Tale of Transforming Growth FactorB (TGFB) Signaling: A Soigné Enigma SMAD2 GSK3B SMAD4 TRAF6 ARHA MAP3K7IP1 SMURF1 PMC5746105__F16 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury SOAT2 IL3RA KDELR3 CD46 SLC27A2 MGLL FAIM CSTB PRKAA1 LXN ACSS2 ABHD2 GOSR2 CEBPG MTTP CFI MGST2 PTS C9 A2M WNT4 MARCO FDPS CYLD CD163 GHR PKLR EPHX2 PRG4 NMI ACSF2 ABCC2 PSMB9 GGCT APOE MSRA CCS CAPZA2 GCLM HRG HAMP GSTM5 NEDD4 BCL2 CXCL12 EHHADH CS IFNGR2 PRKCSH VWF ADIPOR2 SERPINE2 ACSM3 AQP9 DBI C8A LIPE GIG8 ACADL ENPP2 TNFSF10 ASNS LBP HEL-S-1a MLYCD CSA2 ELOVL2 SERPINF2 ACSL3 DDOST VAV2 PMC10379122__F1 Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review SHBG ERG TMPRSS2 PMC7287266__F1 Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation DPAGT1 NUS1 DHCR24 MVK HMGCS1 ALG5 SRD5A3 IPP DOLK HMGCR ACAT2 DHDDS DPM1 PMVK ACAT1 MVD DHCR7 FDPS FDFT1 PMC4147692__F3 Apoptosis induction by the HIV-1 envelope protein at the cell surface CXCR4 CDC2 MTOR BAX PMC9205467__F1 Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges GPX4 FACL4 KEAP1 SLC7A11 NF2 HEL-S-64p ADA HEL-75 IREB2 SLC3A2 TF PMC4147692__F1 Involvement of HIV proteins in intrinsic apoptotic pathways: The viral proteins are marked in yellow BAD ATM APAF1 PTEN RAF1 ATR BAX PMC8524328__F4 Exploration of the existing and candidate crosstalk between the diagrams of the COVID‐19 Disease Map INA FOS RELA MYC INS ARHA COMP PYCARD JUN MAVS ITCH PMC8524328__F5 Interferon type I signalling pathway diagram of the COVID‐19 Disease Map integrated with TF activity derived from transcriptomics data after SARS‐CoV‐2 infection INA IKBKE TLR7 TANK RELA ENG JUN PMC10603981__F1 Signaling pathways involved in ferroptosis GPX4 NUPR1 FACL4 SQSTM1 SLC7A11 ACACA SLC3A2 FASN PMC7067901__F2 Top three molecular networks identified by Ingenuity Pathway Analysis: (A) Network 1 MYLIP DST ZMYM4 TRRAP TRPS1 SFRS8 SLMAP YEATS4 PMC10603981__F2 Necroptosis signaling pathways RIPK1 TRADD RIPK3 PARP1 TRAF2 FADD TLR3 ZBP1 MLKL PMC3290617__F1 Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin IRAK1 TRAF6 IRAK4 IRS1 INSR PMC5145761__F3 Displays canonical BMP pathway identified through Ingenuity Pathway Analysis (IPA) RUNX2 PITX2 SMAD4 SMURF1 FST NOG GREM1 TLX2 CAMK4 NKX2-5 HOXC8 GRB2 SMAD1 DKFZp781O1323 PMC3372896__F1 Central role of Beta-catenin in Wnt signaling and the cadherin complex APC GSK3B TEF LRP5 LRP6 PMC5145761__F1 Displays canonical IL-1 signaling pathway identified through Ingenuity Pathway Analysis (IPA) UNK TRAF6 ECSIT MYD88 JUN PMC7425198__F6 Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins CCL5 PRKCSH SF3B2 DDX5 NUP107 B4GALT1 IL1B TUSC3 RPL34 RPLP0 SEL1L AKAP8 RPL13a RRBP1 YBX1 PTGS2 RLF NUP160 RPL6 CHCHD3 TNF RPL15 SRSF10 SEC63 ZNF384 HMGA1 NUP153 PLRG1 ALG1 RPS25 EGR2 DNAJB11 DNAJA2 RELA HNRNPC CCL20 STT3B NUP98 RBMX SRSF7 RAN RBM22 PMC8476871__F1 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites TRADD RELA RELB TRAF6 CD40 MYD88 TNF FADD LTBR PMC8476871__F2 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites TLR4 TLR9 HEL-S-28 MYD88 TLR1 GAL TIRAP PMC9231801__F2 Three stages of immunological pathway leading to mortality in COVID-19: Stage I (Initiation), with early induction of predominant chemokines upon SARS-CoV-2 infection and viral sepsis CCR5 CCR2 IL1A CCL5 CCL2 TNF CCL3 PMC4487446__F7 Scheme illustrating the signaling pathway involved in the production of chemokines and cytokines induced by prostaglandin F2A (PGF2A) CXCL8 IL6 CCL2 IL1B PMC4203832__F4 Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax MARCKS EPO HAMP MAP3K11 ATF2 MYC UNK HIF1A JUN CDC42 PMC5336598__F1 Role of the unfolded protein response (UPR) in cancer ATF4 EIF2A PMC4741987__F8 ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription C1QBP ZNF32 SP1 PMC2631600__F1 The HMGCR pathway DHCR7 SC5D HMGCR PMC6721423__F1 PTEN-mediated control of cancer stem cells (CSCs) hallmarks CXCR4 GSK3B PAX7 MAOA BMI1 IL6 PTEN MTOR S100A4 IL6R STAT3 PMC8809122__F9 Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway BAX PMC8471358__F1 Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives TLR4 IGF1R IGF1 SMAD2 SMAD4 MTOR STAT3 PMC3867867__F3 Genetic determination of testes in Japanese medaka fish, chicken, and mouse AMH WNT4 DMRT1 WT1 FOXI2 FOXL2 SOX9 FGF9 SRY PMC4104517__F2 Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis AK2 MFN2 BAX PMC5882778__F2 Systemic metabolic cues with Kisspeptin, orexigenic, and anorexigenic neurons POMC PC NPY AgRP PMC5971270__F5 IPA identified “LXR/RXR activation” as the canonical pathway in the ESPs of TC-1 cells with the highest predicted potential/significance affected by the treatment with caerin 1.9, predicted based on label-free quantitation IL16 ABCG4 LPL APOA5 IRF3 LY96 CD36 PMC9083176__F1 Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury TSC2 TSC1 HEL-S-44 MAF1 PTEN RHEB PMC5971270__F4 IPA identified “Tec kinase family signalling” as the canonical pathway in the cells with the highest predicted potential/significance of being affected by the treatment of caerin 1.9, based on iTRAQ data FOS SCEL FADD PMC7279457__F2 Positioning Cx43 in the intercellular coupling by channels in the DC-T cell IS APC CD80 PANX1 PMC6683209__F1 Cyclin D1-CDK4/6-RB pathway and crosstalk in breast cancer TSC2 CDK2 EGFR CDK4 MTOR CDK6 PMC10474074__F2 Kennedy pathway and Lands cycle in ferroptosis GPX4 LPCAT3 FACL4 LPA PMC6429175__F8 Comprehensive pathway of Alzheimer’s disease derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) SNCA BAD CASP12 GSK3B TNF CASP3 APAF1 LPL APP CASP9 DCC CASP8 FADD APOE PMC9611857__F2 A Pathological Interaction between Beta-amyloid and Mitochondria in the Occurrence and Development of Alzheimer’s Disease MFN1 MFN2 FIS1 OPA1 PMC9112566__F1 Endomembrane remodeling in SARS-CoV-2 infection CTSL ACE2 TMPRSS2 PMC3372896__F3 Intersection of pathways controlling Wnt/Beta-catenin signaling and cadherin-mediated adhesion FER EGF FGFR1 SMAD4 SRC PMC3555267__F2 Typical MAPK signaling pathway MAPKAPK2 RHO PMC8147076__F1 Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events AIP AHR PMC5187837__F1 The integrin outside-in signaling BAD ARHA RAC1 MTOR PMC2917906__F1 HIF-1A and HIF-2A have different functions in the cartilage IHH ADAMTS5 RUNX2 RELA PMC11671575__F1 Signaling pathway of FOXF2 in tumor progression BTC GIG8 FOXF2 AREG ZEB2 VGLL4 EGFR IRF2BPL SMAD4 TF PMC8268527__F1 Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer CAND1 UBA3 NEDD8 PMC8034822__F4 Divergent cytokine pathways drive fibrosis IL25 TNF TSLP PMC8151747__F1 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis HEL-S-49 PDC tal-1 TK1 HEL-S-68p PMC8151747__F2 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis tal-1 TK1 PMC5954996__F7 BACTEROIDES FRAGILIS TOXIN COORDINATES A PRO-CARCINOGENIC INFLAMMATORY CASCADE VIA TARGETING OF COLONIC EPITHELIAL CELLS APC STAT3 PMC7773148__F1 Fatty acid and endocannabinoid metabolism by cytochrome P450 classes CYP2J2 CYP2C9 CYP4F2 CYP4F3 CYP4F12 PMC5133730__F7 Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway AVP AQP2 PMC11044490__F6 DEGs in plant hormone signal transduction pathway BIN2 EBF2 TF PMC7494970__F2 Involvement of Ang-II, ACE2, and Ang-1–7 in atherogenic pathways NOX4 ARHA NOX5 ACE2 ADAM17 PMC4779544__F1 Proposed pathway connecting HMGB1, TLR4, TLR2, MyD88, and TRIF signaling to inflammation and regeneration following muscle ischemia HMGB1 TLR4 MYD88 PMC4409274__F7 Cancer activates Stat3 in muscle to stimulate loss of muscle mass via two signaling pathways SMAD2 STAT3 PMC8957418__F3 Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis ARHA RHO TGFA PMC4646237__F9 Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway IGF1 F2 IRS1 PMC10854933__F2 An illustration of the theoretical modes of action of the MRGPRX2 signaling pathway inhibitors MRGPRX2 LYN SRC ORAI1 PMC3689254__F2 General scheme of EGFR activation EGFR PTEN MTOR PMC3689254__F3 EGFR activation of the Ras/Raf/MEK/MAPK pathway FOS ATF2 EGFR GRB2 PMC3689254__F6 Several flavonoid compounds also target the Fyn/Src signaling pathway STAT1 COX2 FYN ATF2 SRC PCNA PMC9526582__F10 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer CILP NUMB DDR1 PSG1 LRRC32 PCK1 FLNA LYN VEGFA FABP1 CD36 PMC9348576__F2 Products of deregulated genes in Dp(16)1Yey/+ are enriched in proteins linked to glutamate receptor signaling pathway and in proteins involved in an ARC–PSD95 complex linked to ID and intelligence ARHGAP32 GDA SHANK3 HRAS PMC9526582__F13 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer PCK1 CD36 PMC7758035__F5 GA biosynthesis and inactivation, highlighting the GA signal transduction pathway that enables GA homeostasis TPR ERF TF PMC5036257__F7 A new SLIT/miR-218/(NFKB/POU2F2/ROBO1) signalling pathway promotes gastric cancer (GC) metastasis SLIT3 SLIT2 POU2F2 PMC9512455__F7 Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice BAAT CYP7A1 PMC3317641__F7 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes FOXC1 GADD45B AMFR TAP2 PLAUR SFN DUSP14 ASNS TNLG2B SOX9 OSMR FKBP1A PMC6501790__F2 Epigenetic control and the circadian clock: linking metabolism to neuronal responses NAMPT NHLH2 SIRT1 STAT3 PMC8471000__F2 Metabolic Reprogramming and Host Tolerance: A Novel Concept to Understand Sepsis-Associated AKI SIRT6 SIRT1 PMC3317641__F6 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes UGT1A3 MYC HMGCS1 PSAT1 LTBP2 KLF4 EMP2 KRT5 THBS1 ETS2 TAF5L ADM KLF6 KRT14 SPRR1B PMC6743121__F8 Schematic depicting HSPA5 protects against DHA-induced ferroptosis in glioma cells ELF2 HEL-S-89n GPX4 ATF4 EIF2A PMC6297832__F6 Proposed mechanisms of anthocyanin’s effect on NVU dysfunction after ischemic stroke NLRP3 BAD BAX PMC10531065__F8 Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach ANXA1 CBX3 HEL-S-30 RPA1 HEL-S-34 PROX2 DEK HEL-S-47e MTHFD1 PADI2 HYOU1 PHGDH EIF3C SLC25A6 HEL-S-93 FASN PMC4539601__F4 Inferred network models capture oncogenic signaling pathways in melanoma RS1 TSC2 BRAF SRC ATR PCNA STAR PMC8292951__F1 RNA Methylation in Systemic Lupus Erythematosus SOCS2 METTL14 IL7 SOCS3 METTL3 CISH ASB2 IL2 PMC5554748__F8 Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NFKB and JAK-STAT Pathway STAT1 COX2 TLR4 SRC MYD88 IL1B PMC8975241__F1 Effect of PD-1 on T cell-mediated signaling pathways and metabolism FYN CPT1A NFATC1 APC LCK ZAP70 MTOR PMC8975241__F2 Metabolic effects of PD-1 ablation or blockade in effector (Teff) and regulatory (Treg) T cells NFATC1 SRC MTOR PMC4539601__F2 Cluster-guided pathway analysis of the response map HEL-S-62p BAD BRAF EBP EGFR RS1 COX2 ATM HEL164 SRC C6 BCL2 ATR JUN PCNA PMC9601210__F7 Therapeutic Targeting of NFKB in Acute Lung Injury: A Double-Edged Sword RELA SYK PMC7014257__F2 Strategies to overcome anti-angiogenic therapy resistance VEGFA CCL18 EPHA2 PMC4906396__F5 Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes OSM STAR PMC3474186__F3 Apoptotic signaling through tumor necrosis factor superfamily receptor 6 (Fas) and tumor necrosis factor receptor (TNFR) CASP3 TRADD APAF1 CASP9 TRAF2 IL1B FADD PMC3474186__F4 Signaling pathways mediated by rat sarcoma (Ras) and protein kinase B (Akt) CASP3 MDM2 CASP9 PTEN MTOR PMC8082996__F9 Serum-derived exosomes containing NEAT1 promote the occurrence of rheumatoid arthritis through regulation of miR-144-3p/ROCK2 axis ROCK2 CCND1 PMC7654839__F1 Optogenetic tools for remote activation of intracellular Ca2+ signaling CAD OCA2 ORAI1 STIM1 PMC4021255__F3 Ingenuity Pathway Analysis of genes negatively regulated by unliganded GR SPARC PLCL1 AIP TWIST2 SULF2 EFNA1 SMPD2 MMP11 C1QTNF2 ITGB6 BCL2L1 THRA CXCL12 ST6GAL1 PMC4021255__F4 Ingenuity Pathway Analysis of genes positively regulated by unliganded GR HEL-S-62p IRF9 NR3C1 RTP4 COLEC12 CD74 STAT5B SP100 USP18 CCND2 OASL CH25H P2RY6 GIG8 TMSB4X DNASE2 AID PRLR TMSB10 PSMB9 CP PMC2938637__F2 Current model of early symbiotic signaling pathways NUP133 NUP85 PMC5302036__F3 Switching off malignant mesothelioma: exploiting the hypoxic microenvironment EGFR CCNB1 RAD52 UBA7 MSH2 MTOR AXL CDKN2A HEL-S-133P HK2 CCND2 BAP1 PMC8534876__F8 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration SUN1 LIMK2 RHO BAX PMC8560683__F1 Klotho as Potential Autophagy Regulator and Therapeutic Target IGF1 BCL2 MTOR PMC8534876__F3 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration PC SHH RAC1 PMC8841529__F6 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks CTC1 RNF168 STN1 TEN1 RIF1 SHLD3 SHLD2 SHLD1 PMC4870238__F1 Signal transduction pathways that mediate Treg resistance converge on the PI3K/Akt pathway TLR8 TLR4 TLR9 TRAF5 TRAF1 TRAF3 TRAF6 MYD88 TLR1 TNF TRAF2 STAT3 PMC2797270__F8 Summary of Trif-biased signaling and selective p38 activation by sMLA TBK1 CD14 TLR4 LBP IRF3 MYD88 MAL PMC8648636__F2 Drug combination screening as a translational approach toward an improved drug therapy for chordoma EGF HGF EGFR PTEN MTOR TGFA PMC8841529__F1 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks RIF1 BLM MDC1 BARD1 SSB L3MBTL2 MCM7 LIG1 MRE11A BRCA1 CDC45 PAXX MCM3 RNF168 MCM5 MCM6 RNF8 MCM2 ATM GC RAD52 ERCC1 PCNA PMC11594856__F1 Signaling pathway of CTLA-4 CD80 PMC8946661__F5 Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer SUV39H1 MMP2 SETD7 TWIST1 GLI3 TP73 VEGFA SHH CCND1 CCNE1 PMC9027775__F5 Human RelA Transgene on Murine Macrophage Inflammatory Responses TEC BCL2L1 MAF SRC IRF-1 IL1A FOS CXCL10 VEGFA CEBPA EDNRB CDKN1A CXCL9 KDM1B HEL113 SLC40A1 TNFAIP3 UBE2L6 MSMO1 IFIT1 IFIT3 IFIT2 FLCN DHX58 NCK2 VSIG4 GEM TRIM21 TGFBR1 HAVCR2 GBP5 IL1R1 CD300A RIPK2 HEL-S-104 FRMD4B TUBB2A PPP1R15A CEBPD HAAO CSTF2 AHR NOD1 RAB11FIP1 POLR2A GBP2 CCL17 GBP3 SPEN CAV2 PYHIN1 NR1H3 CGN SELE SLC4A7 SQLE SPSB1 MAFB CFB SDC1 SPSB4 MAD2L1 PTGS2 CBL PPARG OSM PMC7094200__F3 Other signaling mechanisms regulated by RSV in a DCM heart TLR4 KEAP1 FGF2 UCP2 PMC9640784__F2 Select mechanisms of HER2-targeted resistance MUC4 CDK2 CD44 CCND1 CDK4 MTOR CDK6 PMC3242881__F6A Src REGULATES SPHINGOSINE-1-PHOSPHATE MEDIATED SMOOTH MUSCLE CELL MIGRATION GSK3B SRC S1PR1 S1PR3 PMC8466012__F3 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism SOX2 HEL-S-30 MYC KLF4 HIF3A HK2 PMC8466012__F4 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism PDK4 HIF1A PMC5494602__F9 Model of TRAF3-dependent regulation of RIG-I signaling pathway by NS1/126-225 TBK1 TRAF3 IRF3 TRIM25 MAVS PMC8194041__F2 Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis SMAD2 ZEB2 SMAD4 PMC3876432__F3 IL-6-STAT3 signaling and premature senescence IL1A NFKB1 RELA CXCL8 IGFBP5 STAT3 PMC2785637__F1 Schematic overview of hepatic lipid biosynthetic pathways TG PSD PEMT PMC4065097__F1 Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico CD14 CDKN2D FOS PTGS2 HEL-S-102 DAPK2 NDUFA2 AHSA1 CYP3A4 GJA1 IL23A GRAP2 CDKL1 MAPK1 STAT3 PMC7445477__F7 Troxerutin on vascular inflammatory mediators and expression of microRNA-146a/NFKB signaling pathway in aorta of healthy and diabetic rats IRAK1 TRAF6 IL6 IL1B PMC3594312__F5 Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines PLAUR VEGFA TRAF6 RIPK2 IPP AHR EGR2 ATF4 BIRC3 KLF4 APP JUND TRAF3IP2 TNFRSF10B SLC1A3 TRAF2 IRF-1 NR1D1 SOCS1 CYCS PMC3766771__F1 Transcriptional regulation of effector and memory CD8+ T cell fates IL21R TSC2 CD133 TSC1 SOCS3 STAT4 KLF2 MTOR FOXO1 ELL STAT3 PMC6198389__F3 Possible therapeutic strategies for cancer stem cell elimination CD44 ABCG2 MTOR PMC3766771__F2 Transcriptional regulation of effector and memory CD8+ T cell fates CD80 PMC2287285__F7 Comparison models summarizing how eIF4E is not only downstream of the PI3K–AKT pathway (left) but can modulate this PI3K–Akt axis through NBS1 (right) PML CCNA2 CCNB1 MDM2 CCND1 EIF4E CCNE1 PMC12144634__F4 Cell cycle proteins: Linking the cell cycle to tumors PLK1 WEE1 ATM CDK2 CDC2 ATR PMC9603526__F2 Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease DAO PMC4355290__F5 Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In Vitro HEL-S-125m BCR KRT19 ALB HEL-S-99n EZR SERPINB5 HEL113 HSPD1 HYOU1 HEL-S-162eP PMC3478445__F12 Model of Stat3, Ascl1a, and Lin28a in inducing maximal Müller glial proliferation in the light-damaged zebrafish retina HBEGF LIN28A STAT3 PMC8473751__F6 Insight in the Recent Application of Polyphenols From Biomass CXCL1 MMP2 MMP9 CXCL2 PTEN FOXC2 E2F3 SIRT1 HEL-S-68p PMC8473751__F3 Insight in the Recent Application of Polyphenols From Biomass GCLM NQO1 NGB PMC7666735__F8 Mechanisms contributing to RES inhibiting the metastatic potential of cervical cancer cells MMP3 TWIST1 JAK1 CDH2 STAT3 PMC7072286__F6 Venn diagram illustrating differential molecular pathways in recGB vs ITK KRCC1 POLE MBD4 ATM TREX2 HUS1 MSH6 MDM2 RAD50 RAD51 MSH3 MSH2 BARD1 CTLA4 MRE11A BRCA1 CHKA LCK TREX1 ERCC1 CD80 XPA ATR PCNA PMC11897911__F6 PGAM5 activating NFKB signaling pathway to promote polarization of M1 macrophages PGAM5 TNF MTOR PMC7547764__F1 c-MET/HGF pathway in gastric cancer pathogenesis HGF EGFR GRB2 SRC MTOR PMC7897492__F6 Working Model H2AX RNF169 DYRK1B POLI PMC9250438__F6 Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types PTPRT HGF MMP2 STAT3 PMC9437119__F8 Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics MFF TBC1D15 FIS1 PMC5605936__F1 Antiviral apoptotic pathways TBK1 RIPK1 TRADD IRF3 FADD TLR3 BAX PMC4611218__F3 Effect of oral foreign plasmid pcDNA3 on complement activation classical pathway HEL-S-62p C9 SET MASP1 C6 RAN PMC155392__F3 Predicted pathways for degradation, transport, and metabolism of chitin by M NAGA CP PMC4611218__F2 Effect of orally administered foreign plasmid pDNA3 on proteasome degradation pathway SET HEL-S-71 UBE2H RPN2 UBE2R2 UBE2B UBE2D2 UBE2E3 RPN1 UBE2E1 IFNG UBE2A PMC8124914__F2 Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy VASP ARHA RHO PMC4581061__F3 Induction of the extrinsic pathway of apoptosis by phthalates SP1 PMC8902906__F3 Biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19 CXCL1 CCL20 IFNG PMC3514880__F3 Genome sequences of wild and domestic bactrian camels PDK2 GRB2 INS MTOR FOXO1 INSR CBL PMC9156568__F15 Characterizing the Propagation Pathway of Neuropathological Events of Alzheimer’s Disease Using Harmonic Wavelet Analysis POLE INS LAT PMC5571732__F1 Methionine metabolic pathway HEL-S-61p MTR MAT1A PMC3924811__F2 Mechanosignaling in Bone Health, Trauma and Inflammation COX2 RUNX2 FOS SRC JUN PMC4526774__F2 Pim signaling in MM TSC2 BAD ELF3 MAX MYC EIF4E RHEB PMC8046019__F1 Ghrelin-induced effector pathways and unavowed signaling hotspots ULK1 LEAP2 SMAD2 GHR SMAD4 SRC MTOR SIRT1 RHEB PMC3512188__F3 Roles of miRNAs in DNA damage response ATM PPM1D MDM2 H2AX SIRT1 CDC42 PMC8199999__F1 Minor Intron Splicing from Basic Science to Disease ZRSR2 STK11 ZNF547 RNPC3 PMC8199999__F6 Minor Intron Splicing from Basic Science to Disease INS GEMIN2 GEMIN5 PHAX SMN1 PMC8718186__F1 cGAS‒STING signaling and function in metabolism and kidney diseases TBK1 CGAS IRF3 PMC8161298__F1 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis SOX2 TERT PMC3857355__F8 Therapeutic strategies that have been used to target the TGFB signaling pathway to reduce scarring SMAD2 SMAD4 PMC3163574__F2 Identification and Visualization of CD8+ T Cell Mediated IFNG Signaling in Target Cells during an Antiviral Immune Response in the Brain STAT1 IFNGR2 JAK1 IFNGR1 IFNG PMC3430731__F1 Signaling pathways regulating lipogenesis in cancer cells TIGAR AKR1B10 SLC38A5 MYC MTOR FASN MAL PMC4359552__F1 Conceptual model of general lifestyle effects, salient CHD pathogenetic pathways and CHD hallmarks NLRP3 IGF1 MPO VCAM1 TNF BDNF TF PMC11570929__F4 mTOR signaling pathway and cellular senescence TSC2 TSC1 PRR5 CCND1 CDK4 DEPTOR RHEB PMC11570929__F5 Insulin-like signaling pathway and cellular senescence TSC2 TSC1 JAK1 MTOR IRS1 RHEB STAT3 PMC8161298__F7 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis PTMS DKFZp781B1423 CTCF MDM2 LATS2 PMC3857355__F3 TGFB/Smad signal transduction pathway SMAD2 SMAD4 PMC8738154__F5 Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer NF1 EGF EGFR PTEN MTOR PMC3757373__F1 Methionine metabolism in liver TH HEL-S-61p PMC5865700__F1 Shh signaling pathway SUFU SHH SMO PMC9218565__F1 Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy NAMPT MMP2 NNMT CD44 CDK12 SP1 MTOR BRCA1 STAT3 PMC4273979__F1 Pikromycin and methymycin biosynthetic pathway in Streptomyces venezuelae ATCC 15439 DES NME2 HEL-S-5 PMC3315683__F1 Phosphatidylinositol 3-kinase signaling pathway PTEN INPP4B RHEB PMC3682211__F7 Aspirin targets multiple components of the AMPK/mTOR signaling pathway in colorectal cancer TSC2 TSC1 MTOR PMC9484965__F9 Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Experimental Analyses BAD IGF1 MDM2 BAX PMC3828604__F1 Interactions of stress proteins and cell surface TLR signaling pathways TBK1 TLR4 ATM IRAK1 ATF4 TRAF3 TRAF6 IRF3 MYD88 HSF1 XBP1 PMC6767494__F1 Management of cancer by fecal microbiota transplant TNF STAT3 PMC3828604__F3 Stress proteins in crosstalk with cytoplasmic PRR signaling TBK1 NOD1 IRF7 ATF4 TRAF3 IRF3 NOD2 PMC6480560__F1 Transcriptional changes of type I interferon (IFN-I) signaling pathway members in the cerebellum of canine distemper virus (CDV)-infected compared to control dogs STAT2 IRF7 IRF9 IRF3 MYD88 TLR3 MX2 MX1 STAT1 ISG15 OASL OAS1 OAS2 TLR7 TYK2 JAK1 IRF-1 PMC11855671__F6 Biosynthetic and signal transduction pathways of SA NPR3 HPD PMC6498735__F1 Regulatory pathways leading to stem-like cells underlie prostate cancer progression FOXA1 MYC CD44 PMC3621568__F1 TGFB transduces signaling through Smad and non-Smad signaling pathways SMAD2 ATF2 SMAD4 SMURF1 JUN PMC1998884__F1 Pathways involved in GSIS PDC CS PC PGP CIC MAL PMC8085809__F2 Microbiota signalling to the host circadian and metabolic systems occurs via both contact-dependent mechanisms and contact-independent mechanisms NF2 IL22 PYY PMC3209802__F1 Assembly of checkpoint and repair machineries at DNA damage sites RNF8 ATM MDC1 H2AX PMC10909944__F9 Mechanistic schematic model of action of circRNA_SLC8A1 in macrophages against Mtb infection SQSTM1 IL6 TNF PMC6736526__F3 Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect NOTCH1 CA3 NEUROD1 PROX1 PMC11036733__F6 Dengue virus pathogenesis and host molecular machineries CGAS STAT2 C1S TRIM69 PMC4547409__F9 Model illustrating the mechanism underlying inhibition of TGFB1–induced EMT and cell migration by KF SMAD4 PMC8910364__F9 Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway MMP3 COX2 PMC12121910__F4 Integrative analysis of metabolomics and transcriptomics revealing activation of lignin biosynthesis pathway in rice infected by Pst HP CAD PRX PMC6844540__F12 PI3K-AKT signaling pathway adapted from KEGG (ID: hsa04151) (A) the predicted targets and genes were signed in red; (B) the known targets and genes were signed in red MYB ME1 BAD EBP PTEN EIF4E MTOR CLU RHEB TSC2 PI3 BCR MDM2 SYK RAF1 EIF4B RBL2 CD19 PMC6746687__F3 Schematic diagram of EB virus involved in the G1/S transition ARID3A ATM CDK4 PCNA CDK6 PMC9449326__F2 Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis MYB EGF BAD HGF EBP EGFR MAPK3 GSK3B MYC PTEN MTOR FGFR2 BCR ATF4 RBL2 CD19 VEGFA RAC1 EIF4E IL6 ITGB1 BRCA1 TSC2 IGF1 NFKB1 CDK2 RELA PMC8085147__F2 CGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA CGAS IRF3 IL6 TNF PMC6412864__F3 Apoptotic signaling during ER stress ATF4 EIF2A TRAF2 PMC6895604__F2 Targeting senescent cells in translational medicine BAD RBPJ LBR ATM HEL-S-11 PTEN MTOR ATR BAX PMC6412864__F2 Crosstalk between UPR and autophagy LAMP3 LAMP2 ATF4 EIF2A XBP1 PMC3001129__F2 NOD-like receptor signaling beyond the inflammasome NOD1 IRAK1 NLRP12 NLRX1 RIGI MYD88 NOD2 IFNG PMC3539662__F1 Kaposi sarcoma-associated herpesvirus K1 activates PI3K/AKT/mTOR signaling thereby activating protein synthesis and survival pathways, while inhibiting apoptotic pathways LYN GSK3B SYK MTOR PMC3565070__F3 Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections CXCL1 MPO EGFR IL1R2 HBEGF IL24 CXCL3 CXCL2 LPO MUC5B MUC2 HMOX1 DDIT3 CFTR FOXA2 CXCR4 PMC6859544__F1 Redox Regulation in Glucose Metabolism HEL-S-44 PMC5393166__F1 Schematic overview of the Nrf2 pathway MAF KEAP1 RBX1 PMC5853106__F2 Non-Canonical Wnt-signaling: Non-canonical Wnt/PCP (planar cell polarity) pathway NLK HEL-S-11 ARHA RYK CDC42 PMC8655231__F2 Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease ABCD4 CYLD IRAK1 MYD88 TAB3 PMC5853106__F3 Wnt Signaling Pathway in Cancer APC LRP5 LRP6 RYK PMC9402571__F6 Models for the negative regulation of NFKB signaling pathways by caspase-3-mediated cleavage of NFKBs CASP3 CASP9 FADD PMC5853106__F1 The Wnt Signaling Pathway in Cancer LEF1 APC LRP5 LRP6 PMC9243210__F2 Metabolic reprogramming and epigenetic modifications on the path to cancer KAT2A OGA OGT PMC5805151__F1 Interaction between stress responses and circadian metabolism in metabolic disease DBP XBP1 PMC7984428__F2 Simplified canonical model of NMD pathway activation (A) in human cells which is controlled by three different ways so far and yet to be identified (B) UPF2 SMG1 XRN1 UPF3B SMG6 PMC8273387__F4 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes RIPK1 RIPK3 BCL2 CASP8 MLKL PMC3502514__F1 Activation of stress signalling pathways in the liver of sows during lactation CFB HP CRP GPX1 HEL-S-128m UGT1A1 PMC8273387__F2 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes RIPK1 TRADD CYLD RIPK3 OTULIN TRAF2 FADD MLKL PMC8374049__F2 Inflammasome Signaling: A Novel Paradigm of Hub Platform in Innate Immunity for Cancer Immunology and Immunotherapy TH GSDMC GSDMB GSDMD DFNA5 PMC11673533__F1 Artificial sweeteners affect hormonal pathways in breast cancer IGF1 INS PMC3203793__F1 Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling SIRT2 APC GSK3B PMC4679438__F3 mTOR and its tight regulation for iNKT cell development and effector function TSC2 TSC1 EIF4E CAD RHEB PMC9102229__F7 Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus STAT1 EGFR IRF3 STAT3 PMC5492169__F9 Schematic model describing the CD99 peptide-induced signal transduction pathway PIN1 CD99 RAF1 HRAS PMC4679438__F2 mTOR and its tight regulation for iNKT cell development and effector function TSC1 FYN CD1D RHEB PMC6722098__F1 DEGs’ products protein-protein interaction network for each mineral ADAM2 APOO VCAN POSTN ELOA COMP CYCS PMC6155514__F5 Real-time carbon allocation into biogenic volatile organic compounds (BVOCs) and respiratory carbon dioxide (CO2) traced by PTR-TOF-MS, 13CO2 laser spectroscopy and 13C-pyruvate labelling PDC IPP PMC4632296__F8 A working model depicting that RILP interacts with RalGDS to inhibit Ral pathway RALA RILP PMC6628296__F1 Canonical Wnt signaling pathway illustrating therapeutic intervention points targeted by Wnt modulators AXIN1 LRP5 LRP6 PORCN DKK1 PMC3203793__F6 Molecular modulation of peripheral myelination by the Sirt2/Par-3/aPKC pathway SIRT2 APC GSK3B PMC6231577__F1 Effect of radiotherapy on DNA repair, mitochondrial function, cellular ROS, and EMT ATM CCNB1 SSB CCND1 PARP1 MTOR H2AX PRX PMC5543744__F6 Proposed mechanism of hypoxic-conditioned secretome effects on liver regeneration SOCS3 SIRT1 STAT3 PMC3464683__F3 Schematic representation of a plant cell with the major components involved in symbiotic signaling and defense signaling NUP133 NUP85 REM1 PMC6865084__F3 Core genes involved in the promotion of depression in patients with ovarian cancer SPARC EGR1 COL3A1 FOS ATF3 CCL2 KNS2 TMEM176A PRELP PLOD2 PLA2G7 DCN PLAT SMARCA4 ZFP36 PNOC HEL-S-2 TIMP3 FOSB SERPING1 JUND CHPT1 JUNB CXCL12 PMC6215314__F6 Illustration of heterogeneous cancer death induced by dihydroartemisinin plus epirubicin liposomes through autophagy, apoptosis and necrosis UVRAG ATG14 BAX PMC7902034__F3 Activation of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of IFN genes (STING) signaling pathway and AIM2/IFI16 inflammasome CGAS IRF3 AIM2 IL1B STIM1 IFI16 GSDMD SLC19A1 PMC8164981__F1 Bhlhe40 as a TRM metabolic regulator NOTCH2 BHLHB2 RUNX3 TGFBR2 NOTCH1 ID3 PMC4260746__F4 Caspase-1 activation by inflammasomes leads to pro-inflammatory cytokine production: Inflammasomes can be triggered by various stimuli NLRP3 HMGB1 NLRC4 NLRP1 MYD88 IL1B TIRAP PMC5894239__F5 Functional network overrepresented in the list of differentially expressed miRNAs in response to infection of bovine macrophages with Streptococcus agalactiae strain (a) ST103 and (b) ST12 MRAP PMC7294136__F1 Functions of extracellular S100A4 protein TLR4 S100A4 PMC7902034__F1 Localization, intracellular trafficking, and signaling pathways of nucleic acid-sensing Toll-like receptors (TLRs) TBK1 TLR8 TLR7 TLR9 IRF7 UNC93B1 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC3747383__F1 PPARG transduction pathway COX2 EBP CDK5 LPL PMC4671727__F1 Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease HEL-S-62p C6 PMC96649__F4 Stimulation of iNOS production by Pln is dependent on the IFNG signaling pathway STAT1 JAK1 NOS2 IRF-1 PMC2858523__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway and affected disease genes in disorders of the neurocardiofacialcutaneous syndrome family CS BRAF GRB2 SPRED1 SHOC2 RAF1 SOS1 HRAS PMC7857397__GA Neutralizing auto-Abs to type I IFNs underlie life-threatening COVID-19 pneumonia IRF7 IFNAR2 IFNAR1 TLR3 PMC3010252__F1 Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms NF1 CS BRAF GRB2 SPRED1 SHOC2 RAF1 SOS1 HRAS PMC9470853__F7 Fatty acid export (FAX) proteins contribute to oil production in the green microalga Chlamydomonas reinhardtii ABCA2 FAT1 PMC11602941__F2 TGFB family signaling pathway NODAL SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC11602941__F3 TGFB family signaling in human pluripotent stem cells SOX2 NODAL SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7882887__F4 Emerging role of estrogen related receptorA in complications of non-small cell lung cancers TSC2 TSC1 MTOR PMC5003543__F4 Working model of consequences of PREX2 truncating mutations IGF2 PTEN RAC1 CDKN1C PREX2 PMC7196371__F9 Functions of HT in AD KEAP1 STAT3 PMC7324377__F1 Biological pathways associated with the response to Ni(S-tcitr)2 in yeast APOE PMC4654310__F6 Schematic model of SOCS-1 induction in a TLR4/MyD88-dependent and IFN-Beta-dependent signaling pathway STAT1 TLR4 MYD88 JAK1 PMC7809757__F1 EDA signaling pathway EDARADD EDAR TRAF6 PMC9453694__F1 Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer EGFR GSK3B PTEN PMC7902134__F3 Yixin-Shu Capsules Ameliorated Ischemia-Induced Heart Failure by Restoring Trx2 and Inhibiting JNK/p38 Activation DGIC SMAD4 MYD88 TSC2 GNA11 RET MYLK2 BMP10 LDB3 TRH HEL-S-273 ENO2 MSLN ADRA1A LOXL1 IFIH1 SIX2 COL10A1 CP TF NEFL RPLP2 INA HEL-S-62p ENPP1 IKBKG CASR TPM1 ACTA2 HADHB MYL1 MYL3 NOS1AP DES PTEN MYH7 HEL-S-14 TTN COL1A1 CNR1 TNNI3 DMD ROMO1 CACNA1S OAS2 FGF23 JUP CAV3 ANKRD23 CD2 COL1A2 GDNF P4HA3 FKBP1B COL9A1 SP7 GLA PNPLA2 CD19 NR1C1 PPARG PMC8480058__F2 Macrophages and cancer stem cells: a malevolent alliance BTN3A3 CD47 SOX2 CD44 SRC CD80 EPHA4 PMC8041205__F8 TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88 UBE2D1 TRAF6 MYD88 PMC10474437__F2 Differentially expressed non-coding RNAs and their regulatory networks in liver cancer EGF HGF ANXA11 DKK3 SMAD2 APC PTEN CDK6 FOXA1 GRB2 SRC CDK4 TGFA SMAD1 DKFZp781O1323 STAT3 PMC7530268__F1 Ferroptotic cascade GPX4 FACL4 KEAP1 FTH1 SLC7A11 CISD1 HEL-S-64p FTL PMC7689683__F1 Signaling pathways of three estrogen receptors EGFR GRB2 SRC HBEGF PMC6280671__F4 Integrated Analysis Reveals Genomic and Expression Alterations in Signaling Pathways in HNSCC Differing in HPV Status PLK1 SFN EGFR GSK3B PTEN RB1 MTOR FGFR1 ATM BIRC3 MDM2 CASP8 GSK3A TNKS GYS1 EIF4E PPP2R1B CHEK1 FOXO1 DVL3 PARP3 RFC3 CASP3 BIRC2 NFKBIB CDKN1A PIK3CA TNFRSF10B ATR FADD PIK3R2 AKT3 PMC11058355__F2 Functions of Mincle CARD9 SAP130 BCL10 SYK PMC9601310__F7 Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis MUSK LRP4 PMC2686112__F1 VHL gene complex targets hypoxia-inducible factors (HIF) for ubiquitin-mediated degradation F2 EGFR VHL TGFA PMC5953846__F8 Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer NPS ABCC1 ABCG2 ABCB1 FADD BAX PMC3336107__F1 The Unfolded Protein Response in the ER ATF4 XBP1 PMC3154715__F3 Working model of relaxin sustained-vasodilatory response PMC8268128__F2 Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer MMP3 ATM VHL CCL2 TNF SOX9 TERT STAT3 PMC5097071__F6 Redox homeostasis and metabolic changes during the adaptation to proteasome inhibitors ACSF3 ACLY ACSF2 HEL-S-133P PMC4664160__F4 Druggable Sensors of the Unfolded Protein Response NLRP3 ATF4 EIF2A BCL2 TXNIP MCL1 BAX PMC2696125__F2 Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease COX2 BAD BIK BAX PMC7058937__F2 Cell junction formation and maturation under RhoGTPase control in epithelial cells NUMB ARHA RHO RAC1 ARF6 CDC42 PMC11959089__F1 Overview Diagram of Ferroptosis Mechanism in Mycobacterium tuberculosis, EB Virus, and SARS-CoV-2 Infections GPX4 SLC7A11 PTGS2 PTPA PMC6482429__F1 Molecular pathways targeted by the TCMs covered in this review are summarized HMGB1 RIPK1 TLR4 RIPK3 MYD88 TNF MTOR TRAF2 SIRT1 MLKL SIRT3 PMC7404778__F2 Graphical representation of the mechanism of action of bioactive compounds on the antioxidant and immune response MAF MPO KEAP1 TNF PMC9319825__F1 Emerging Biomarker-Guided Therapies in Prostate Cancer PTEN MTOR PMC3051174__F3 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock TLR4 IRF3 MYD88 PMC10975235__F2 Type I IFN signaling STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 MTOR IFNAR1 STAT3 PMC5572260__F4 Signaling in human glioblastoma cell lines after treatment with vascular endothelial growth factor (VEGF), irradiation and axitinib MAPKAPK2 PEG3 CDC42 PMC5569752__F1 ER stress-mediated apoptosis and inflammation in cardiovascular disease NLRP3 ATF4 EIF2A TXNIP BAX PMC5569752__F2 Chronic effect of exercise on the ER stress-associated apoptosis and inflammation NLRP3 TXNIP IL1B BAX PMC5059456__F9 Regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways APC GSK3B TCF4 STAT3 PMC8999618__F2 Sequence Requirements for miR-424-5p Regulating and Function in Cancers WEE1 ATM CDK2 MYC VEGFA CDK4 ATR ATG14 BRCA1 MYT1 PMC8999618__F3 Sequence Requirements for miR-424-5p Regulating and Function in Cancers AMER1 MIEF2 KIF23 FACL4 APC SMAD4 MTOR UCP2 SIRT3 CASP3 PRC1 APAF1 CCND1 BCL2 STAT3 MAL PMC7535921__F8 Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation HDAC3 FANCD2 PMC2984500__F2 Selection of miRNA implicated in the TLR4 signalling pathway TLR4 IRAK1 TRAF6 IRAK4 MYD88 SOCS1 TIRAP MAL PMC9700348__F1 Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via A6B1 Integrin-Fyn-RhoA-ROCK Signaling FYN RHO RAC1 PMC6274979__F1 The activation of Yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) in epithelial cells and fibroblasts BIRC5 AREG CCND1 BCL2L1 AXL PMC2694443__F8 BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway SOST LRP5 LRP6 PMC8034969__F8 JAK-STAT signaling pathway and other related signaling pathway as well as the mechanism of the function of inhibitors identified in this study EGF MTOR PMC8007386__F6 Model depicting the role for microvillous cells involvement in the olfactory epithelium innate immune response to viral infection GNAT3 ALOX5 PLCG2 TRPM5 IL25 IL17RB TRIM25 PTGS1 PMC5837624__F1 Proposed mechanisms of cell injury induced by APOL1 variants NLRP3 TLR4 NLRP12 IL1B APOL1 PMC6862063__F12 Schematic summary of IL-6 induced effects on the JAK-STAT pathway and its main regulator, SOCS SOCS3 IL6 JAK1 IL6R SOCS1 STAT3 PMC3179880__F2 Functional role of skeletal muscle-derived neurotrophic factors after exercise RET GDNF MTOR BDNF RHEB PMC9382818__F1 Improved energy efficiency in microbial fuel cells by bioethanol and electricity co-generation HEL-S-26 PDC HEL-S-32 MDH2 PMC8532137__F1 Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology CYP27A1 CSF1R NR1i1 CYP2R1 IL1B PMC3931066__F7 Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle TOPBP1 ATRIP XPC XPA ATR PCNA PMC8579187__F4 Interactions between the renin–angiotensin, complement and kallikrein–kinin systems on the vascular wall C9 MASP1 C7 C6 MASP2 C1S ACE2 PMC9221635__F2 Telomere Maintenance and the cGAS-STING Pathway in Cancer ATM RAD51 DKC1 NHP2 GAR1 NOP10 SIRT1 TERT PMC9221635__F3 Telomere Maintenance and the cGAS-STING Pathway in Cancer TBK1 CGAS IRF3 PMC11761133__F5 Functional model of resilience ANGPT2 RELN SST ATP8B1 KIF26B PVALB GFAP KLF4 BDNF NTRK2 LINGO1 RBFOX1 PMC7403229__F7 Mechanisms by which melatonin ameliorates oxidative stress via modulation of the Nrf2 pathway in cryopreserved OTs GSTM1 BAX PMC8579187__F1 Renin–angiotensin system ACE2 PMC11276752__F1 Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy CD44 UGDH UXS1 HAS1 RHO HAS3 HAS2 PMC6585057__F7 Summary and schematic diagram of this study STAT1 HLA-A OASL IRF7 CXCL10 CCL5 IFI27 HLA-B MX1 HLA-C PMC11677181__F1 Wnt signaling pathways and the targets of their inhibitors ROCK2 DAAM1 APC PORCN ARHA TNKS JUN PMC2662567__F2 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders NF1 HGF PLAUR PLG CD44 MTOR RHEB PMC6162743__F7 Prx II regulates CSC properties of colorectal cancers via PI3K/AKT, Hedgehog and Wnt/Beta-Catenin signaling APC GSK3B SMO PRX PMC2662567__F3 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders NF1 PLAUR PTEN MTOR RHEB PMC11864756__SF1_3. Analyses of differentially expressed genes that were enriched at different timepoints DUSP5 DUSP10 MAFK FOS APP TNF PMC7497778__F2 Functions of HSCARG in the cytoplasm TRADD TRAF3 IRF3 TNF TRAF2 ASL PMC3339861__F3 EGF decreases sphingolipid biosynthesis transcripts EGF UGCG ACER1 FA2H SGPL1 SPTLC3 SPHK1 DEGS1 SGMS2 DEGS2 KDSR SGPP2 PMC3339861__F4 EGF decreases free fatty acid (FFA) biosynthesis transcripts OLAH EGF HSD17B12 FASN PMC4559887__F1 Homocysteine metabolism and major factors associated with hyperhomocysteinemia in rheumatoid arthritis patients VIT PMC6162743__F2 Overexpressed Prx II regulates stemness-associated properties of HCC cells SOX2 EPCAM FOXM1 CCND1 PRX PMC9313346__F2 P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells APC CD80 PANX1 MTOR PMC5546018__F1 NDRG1 inhibits oncogenic signaling pathways by down-regulating the ErbB family of receptors EGF PAK1 EGFR RAC1 TGFA STAT3 PMC5512074__F6 Schematic overview of p90RSK-mediated regulation of UBR5-containing miRISC TBK1 UBR5 TRAF3 PMC9125963__F2 Mechanisms involved in controlling RNA virus-induced intestinal inflammation TBK1 IRF7 IRAK1 DDX1 NLRP6 TRAF3 DHX36 IRF3 DHX15 MYD88 TLR3 TLR7 MAVS AKT3 PMC9125963__F3 Mechanisms involved in controlling RNA virus-induced intestinal inflammation TBK1 IRF7 NLRP6 IRF3 DHX15 MAVS PMC12143691__F1 Gut microbiota interacts with the mammalian epigenome by generating epigenetic substrates or acting as regulators for chromatin-modifying enzymes METTL14 KAT2A METTL3 ALKBH5 WTAP PMC9125963__F4 Mechanisms involved in controlling RNA virus-induced intestinal inflammation NLRP3 NLRP6 DHX15 GSDMD PMC12143691__F2 Epigenetic modifications induced by gut microbiota promote inflammatory bowel disease (IBD) NLRP3 METTL14 ATG16L1 HDAC3 AHR HDAC5 DKFZp686F0183 HDAC1 CEACAM6 FOXP3 PMC6002427__F3 Signaling pathways in mast cell biology KIT LYN GRB2 SRC SYK LAT PMC2235195__F1 RA synthesis pathway RXRB RARA RARB CYP26A1 CYP26B1 CYP26C1 RXRA PMC3236823__F2 Evolution of the mTOR pathway TSC2 RICTOR TSC1 HERC1 MAP4K3 GSK3B PTEN TNF MTOR SGK1 RHEB INSR PMC6903684__F1 Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria CS FH ACO2 MDH2 PMC8706107__F1 HPV16 Entry into Epithelial Cells: Running a Gauntlet PML CGAS MYPOP SP100 IFNG PMC7316955__F3 Representative pathways of differentially expressed genes INS APP LEPR IL6 ddo MTOR PMC4924657__F8 Double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression JAK1 IL4 ARG1 IRF4 PMC4369817__F6 Schematic diagram of the mechanism whereby miR-16 attenuation contributes to myocardial hypertrophy CCND1 CDK4 CCNE1 STAT3 PMC8819183__F3 Comparison of Tendon Development Versus Tendon Healing and Regeneration GDF6 GDF5 EGR1 gdf7 EGR2 SMAD2 SCX MKX PMC5412355__F3 The UPR downstream signaling pathway ELF2 XBP1 PMC10910709__F9 Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis NLRP3 KEAP1 GSDMD PMC8056081__F2 Diagrams of a hypothesized extreme resistance pathway and its possible relationship to the hypersensitive response AGO4 SAG NRG1 TF PMC8056081__F1 Extreme resistance to viruses in potato and soybean hosts AGO4 SAG NRG1 TF PMC8960923__F1 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer ERG MTOR PMC9592792__F3 Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids APOB ABCG8 ABCG5 GUGU TG PMC9312706__F2 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics SLC7A11 GSK3B BAX PMC8960923__F2 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer ATF4 EIF2A TNF STAT3 PMC9312706__F3 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics PTEN CDC2 MTOR PMC9605520__F3 Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview CYP11A1 HSD3B2 HSD17B1 HSD17B2 HSD17B3 RDH5 AKR1C2 CYP17A1 PMC1052008__F1 Activation of PI3K/Akt signaling in adaptive versus maladaptive hypertrophy PTEN MTOR PMC5871897__F2 RAS-ERK signaling pathway EGF EGFR GRB2 PMC1052008__F3 GSK-3 as a convergence point in hypertrophic signaling HEL-S-28 NFATC3 GATA4 PMC2795439__F1 Androgen-receptor signalling in normal prostate and PCa EGFR STAT3 PMC6539482__F1 The core components of the mammalian Hippo signalling pathway LATS1 LATS2 PMC5871897__F5 Colorectal tumorigenesis by both APC and KRAS mutations APC GSK3B PMC5871897__F3 Aberrancies of the Wnt/Beta-catenin and RAS-ERK pathways and their cooperation in the tumorigenesis APC EGFR GSK3B LRP5 GRB2 LRP6 PMC5871897__F4 Wnt/Beta-catenin and RAS-ERK pathway crosstalk EGF APC EGFR GSK3B LRP5 GRB2 LRP6 PMC7689184__F16 TNFSF15 regulation of antimicrobial pathways TNLG1B ATG16L1 IL16 TRADD NOS2 TRAF2 DKFZp686F0183 NOD2 FADD PMC5884684__F1 Connections between circadian cycles, C/EBPs and the NAD+-Sirt1 pathway may affect G-CSF induced granulopoiesis CEBPA SIRT1 PMC5871897__F8 KYA1797K as a potential strategy to overcome resistance to EGFR targeting drugs in CRC APC EGFR GSK3B LRP5 GRB2 LRP6 TNKS GIP PMC9046588__F2 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy BCO1 GC MYC ARG1 IRF-1 BCL6 CD36 PMC9046588__F3 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy PRMT1 JMJD6 TRAF6 MYD88 PMC7762355__F1 Inflammatory regulation mechanism in a TREM1/2-TLR4-dependent manner in the liver CD14 CARD9 TLR4 TREM1 IRAK1 SRC TRAF6 SYK IRAK4 MYD88 PMC9046588__F4 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy PRMT7 IRF7 PRMT2 PRMT3 TRAF6 IRF3 MAVS PMC9046588__F5 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy TBK1 PRMT1 CGAS IRF7 PRMT6 IRF3 IFI16 PMC9046588__F6 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy ATF4 APC PRMT6 GSK3B MYC GRB2 PTEN RAF1 SOS1 HIF1A PMC6904751__F7 TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKB/VPS34 pathway ULK1 TFEB WIPI2 PMC5705392__F2 Immunobiology of the IL-15-IL-15RA Complex as an Antitumor and Antiviral Agent JAK3 JAK1 STAT3 PMC4336604__F9 How p-CREB acts as a common downstream effector for multiple signaling pathways that regulate BCRP mRNA expression Xie, et.al EGF EGFR CRTC2 PMC4019937__F2 Phylogenomic reconstruction of archaeal fatty acid metabolism CR2 ACD HEL-S-5 PMC7914341__F8 PRLR-SF inhibits pentose phosphate pathway through NEK9-YAP/TEAD1-G6PD/TKT axis in PDAC cells HEL107 NEK9 PMC4209186__F9 Diabetes Recovery By Age-Dependent Conversion of Pancreatic D-Cells Into Insulin Producers MYC ID1 FOXO1 SKP2 PMC2288663__F6 Nucleotide excision repair pathway XPC ERCC1 XPA TF PCNA CPD PMC7352365__F3 The p53/MDM2 pathway by HERC2 NEURL4 HERC2 ATM MDM2 ATR PMC10539948__F1 IFNG signalling pathway STAT1 EHBP1L1 SOCS3 JAK1 MTOR SOCS1 PMC6859819__F3 TRK signalling pathway NGF GRB2 PMC6539482__F3 Interaction between TNFA and the Hippo signalling pathway MOAP1 TRADD LATS1 TRAF2 BAX PMC9640836__F4 PAX5 alterations in B-cell acute lymphoblastic leukemia ZCCHC7 PAX5 ETV6 CDKN2A PMC12183287__F2 BAs contribute to host metabolism in various organs through FXR and TGR5 CYP27A1 UCP1 ABCG5 CCL21 NPC1L1 FGF19 PYY FGFR4 CYP7A1 FASN PMC5806628__F5 Summarization of biological function by a Concept Ontology WAS PTEN UNG PMC5861661__F1 p53-dependent cell death pathway ATM MDM2 BAX PMC6753234__F8 Microbiome–gut–brain axis in relation to AD PC PAH LPCAT1 PMC6162467__F4 CCN2 in regulation of LRP5/6 dependent Wnt signaling CTGF PMC4162195__F6 Working model HES5 NOTCH1 HES1 PMC7572679__F2 Metformin modulates lipid metabolism in the intestine, liver, and adipose tissue MFF GSK3B TG PMC11791038__F7 FAM210B inhibits the proliferation and metastasis of lung adenocarcinoma via interacting with TOM70 and promoting IFNA/B production STAT1 IFIT3 MIMS2 IRF9 IRF3 MAVS PMC2735864__F1 Genetic Variation in TNF and the NFKB Canonical Pathway and Risk of Non-Hodgkin Lymphoma RIPK1 TRADD TRAF5 TRAF2 PMC3295195__F10 A novel mechanism linking ROS/Src/caveolin-mediated activation of the EGFR-ERK signaling pathway to chronic Ang II exposure-induced EMT in cultured renal tubular epithelial cells EGFR HBEGF PMC9036252__F1 Two Modulators of Skeletal Development: BMPs and Proteoglycans BMPR2 ACVR2B ACVR2A RUNX2 MAP3K7IP1 SMAD1 DKFZp781O1323 PMC10950852__F9 Paradigm illustrates the beneficial efficacy of ginseng extracts in modulating circadian rhythm and inflammation FGF21 TLR4 FFAR3 PGLYRP1 NOD2 PCNA PMC8445516__F2 Robinow syndrome-associated genes involved in the WNT/PCP pathway identified in human subjects FZD2 NXN ROR2 PMC3722318__F1 Autophagy master regulator TFEB induces clearance of toxic SERPINA1/Alpha-1-antitrypsin polymers NFKBIA TFEB IL6 SERPINA1 PMC7156751__F7 A simplified tumor environment model STAT1 CXCL1 IL18 TLR4 SOCS3 STAT2 IRF7 CXCL10 IL6 IL1B STAT3 PMC9496462__F1 Dynamic Regulation of NFKB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila CYLD HDAC1 FADD PMC4524510__F2 Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy TRADD FADD PMC2699281__F2 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease DKFZp781B1423 MDM2 BAX PMC2699281__F3 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease HEL-S-62p VCAM1 PMC5281639__F1 Induction of interferons (IFNs) and establishment of an antiviral state in a model chicken cell TBK1 STAT1 STAT2 IRF7 ATF2 TYK2 CSA2 JUN TLR3 MAVS PMC7347488__F1 Renin angiotensin system enzymatic cascade depicting primary receptor systems, biological actions of Angiotensin 2 and Ang-(1–7) and balance between ACE and ACE2 ACE2 PMC6676786__F2 TGFB family members exhibit distinct effects on heart hypertrophy TGFB binds to its own receptors RII and RI, activates TAK1, SMAD2/3, and p38, and moderately promotes cardiac hypertrophy IGF1 GDF15 SMAD2 TGFBR3 GFRAL PMC6676786__F3 The TGFB superfamily in cardiac dysfunction SMAD2 POSTN TGFBR1 SMAD4 NOX4 RHO TCF21 PMC4141540__F7 Schematic model of WNT7B signaling in CRPC cells and osteoblasts MARCKS WNT7B PMC7597673__F9 Photoreceptor metabolism cycles between an anaerobic light cycle and an aerobic dark cycle associated with phototransduction through PDE6 activities and mediated by SIRT6 and HIFlA SIRT6 HIF1A MTOR PMC12006985__F3 An overview of TAG synthesis pathway LPA GPD1 PMC7585830__F3 Positive and negative regulation of Hp (HAMP) transcription and systemic iron homeostasis through the Hp/Fpn signaling pathway ERFE BMP6 EPO HP SMAD4 POR HPR STAT3 PMC7585830__F4 Altered iron homeostasis in breast Cancer Cells and the contribution of their microenvironment SIRT2 HP SMAD4 S1PR1 IL6 IL6R IFNG STAT3 SIRT3 PMC7585830__F5 Summary for Inhibitors of the upstream hepcidin signaling: IL-6/IL6R/JAK/STAT3 and BMP/SMAD pathway BMP6 HAMP SMAD4 STAT3 PMC2857022__F7 Mechanistic model of KLF11-mediated tumor suppression and its antagonism by an oncogenic pathway EGFR SIN3A PMC6581210__F1 Mitochondrial pathways of apoptosis and venetoclax mechanism of action BAD BIK BAX PMC2674698__F1 Structures and metabolic pathway of gangliosides () GM2A HEXA PMC8875868__F5 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance BAG3 ATM PAK4 PTEN PMC8875868__F6 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance HPD HDAC10 MGAT3 PMC8419469__F5 Analysis of Gene Expression Data Incorporating Tumor Purity Information COL27A1 LAMB3 SRC LAMB2 COL5A3 LAMA4 COL5A2 LAMA3 LAMC2 PMC8875868__F7 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance PRMT6 NDP HEL-S-22 PMC2752847__F1 Type I interferon production by dendritic cells in host defense PDC TLR7 IRF3 IRAK4 TLR1 MAVS PMC9434059__F1 Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis ACTA2 SMAD2 COL1A2 COL1A1 SMURF1 CTGF STAT3 PMC8632454__F2 Recent and Upcoming Drug Therapies for Pediatric Heart Failure PLN TNC GC PMC3047627__F3 RECK pathway in stromal–epithelial interaction in prostate cancer MMP3 MMP14 TIMP1 MMP2 RECK TIMP4 TIMP3 MMP9 HRAS PMC6755252__F5 Signaling pathway regulation network of the three validated differentially expressed tRFs PIK3CD SMAD2 GSK3B TRAF6 PDPK1 FGFR1 CHP1 MDM2 SRC COL27A1 LRP6 ADCY3 IRS1 CHRM1 CHD8 HEL-S-273 GNAI3 GRB2 CTNND1 PRKAG2 ATP2A2 GNAO1 HTR2A LAMC1 TGFA MYLK3 MYLK4 RPS6KA6 HTR6 EEF2K NRG3 IGF1R CREB3L2 BTRC MAP2K4 GUCY1A2 ARHGEF12 EGFR TPM3 TGFBR2 ATP1B4 TACR1 SENP2 DKK2 PPM1B SHC3 LPAR3 CCND2 FGF9 NKD1 HRH1 PDGFD GPC1 PHKG2 SCN7A E2F2 SOCS4 KCNJ6 FZD7 BST1 GNAL FGF2 DVL3 CBL MAP2K1 SKP2 APPL1 PMC10879340__F4 Zebrafish Studies on TGFB Signaling and Pharyngeal Arch Patterning GREM2 PRRX1 HAND2 GATA3 BARX1 PMC8215710__F1 RIPK1-Associated Inborn Errors of Innate Immunity NLRP3 RIPK1 TRADD TNF TRAF2 FADD TAB3 PMC8739918__F4 Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis DHRS7B TYSND1 TLR4 CXCL10 LBP IFNG PMC9047021__F1 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer DGCR8 DROSHA RAN PMC3849893__F1 Interferon signaling pathway STAT2 IRF9 TYK2 JAK1 PMC9047021__F2 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer ULK1 TLR4 MYD88 PMC3800064__F2 The canonical and noncanonical NFKB pathway RELA TRAF3 RELB PMC1280267__F7 Model schema for the phosphorylation of CRMP-2 by Rho kinase, Cdk5, and GSK-3B NUMB FYN SEMA3A GSK3B CDK5 RHO PMC9247520__F2 Cryptic Phosphorylation-Mediated Divergent Biosynthesis of High-Carbon Sugar Nucleoside Antifungals MALL POLK POLI PMC9047021__F3 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer ATG16L1 SENP1 DKFZp686F0183 PMC9047021__F4 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer DGCR8 KAT2A PHF5A MTOR RHEB PMC8005608__F3 TRIM-mediated regulation of innate immune signaling pathways TBK1 CGAS TANK TLR9 TRIM21 TRAF3 TRAF6 MYD88 NOD2 NLRP3 TLR8 IL16 TLR7 TLR4 ECSIT DDX41 TRIM8 IRF3 TRIM6 TRIM4 TRIM29 TRIM25 TRIM26 TLR3 TRIM65 TRIM23 TRIM40 TRIM13 TRIM14 TRIM38 TRIM32 TRIM56 MAVS TAB3 PMC7999520__F8 The signaling pathway by which the neogenin ligand RGMc enhances follicular development COX2 COX1 OXTR EDN2 TBXA2R ADRA1D PMC2963106__F2 VHL in clear-cell renal cell carcinoma and its relation to targeted therapy MAPKAPK2 EPO EGFR MAPKAPK3 BNIP3 MTOR PMC4169143__F1 Back to the Future: Oral targeted therapy for RA and other autoimmune diseases TSC2 TSC1 GRB2 SHE JAK1 MTOR RHEB MLST8 PMC6883692__F5 Tobacco-smoking associated genes map to interconnected interferon and stress response signaling networks STAT1 IFIT3 OAS1 OAS2 APAF1 KLF4 SERPING1 IFNAR1 IFI35 AIM2 SASH1 SP100 PMC10151830__F7 Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy ACACA DES ACADM FASN HEL-S-162eP PMC6549073__F9 Cisplatin-induced apoptosis in p53-intact and p53-disrupted signaling pathway conditions WEE1 CDC2 ATR PMC4625378__F2 Ceramide is the hub of sphingolipid metabolism CERS3 LASS1 DES CERS5 SMS CERS2 CERS6 PMC5649420__F2 Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program BAMBI FYN TLR4 EGFR LYN SMAD4 TRAF6 ARHA PTEN MYD88 PMC4423712__F1 Cardiolipin synthesis and remodeling pathway PGS1 CDS1 PC PGP PMC6497892__F2 Comprehensive overview of the role of Clusterin on apoptosis-related events in cancer cells IGF1 ATM PMC4637098__F2 Kelch-like chicken erythroid-derived cap “n” collar homology factor-associated protein 1- (Keap1-) NF-E2-related factor 2- (Nrf2) antioxidant response element (ARE) signaling pathway MAF KEAP1 RBX1 JUN NQO1 PMC7311391__F6 Overall regulatory networks of miRNAs, circRNAs and mRNAs CASP3 BCL2 BAX PMC9450187__F1 Molecular Mechanisms of New Bone Formation in Axial Spondyloarthritis TPH1 HTR1B LRP5 LRP6 PMC6829950__F7 Summary of SP600125 enhances C-2-induced cell death in bladder cancer cells through resisting JNK- SQSTM1/p62- Nrf2 mediated anti-apoptotic pathway and switching autophagy to apoptosis ATG3 KEAP1 DKFZp686F0183 PMC10853543__F4 SOX TFs acts as the hub of signaling pathways in the tumorigenesis CD133 NUMB HGF ALK FLT4 SMAD2 ETV6 GSK3B FOXQ1 SOX1 CCL7 FGFR4 SOX18 BMF IGF2BP2 IL6R SOX7 SOX9 SOX4 CCR1 NLRP3 FGFBP1 MMP7 MCAM JUP GOT2 SOX13 FRS2 SOX11 SOX12 SOX30 FGF19 DSC3 EZH2 CDH2 SOX2 IGF1 TWIST1 ASNS GLS PMC8703482__F2 B Cell Involvement in the Pathogenesis of Ankylosing Spondylitis B2M CD74 SIRT1 PMC7923882__F13 Mechanisms for poly(dA:dT)-mediated HSV-2 inhibition in human cervical epithelial cells STAT2 IRF7 GBP5 RIGI IRF3 IFNAR2 IFNAR1 STAT1 ISG15 OAS1 OAS2 TYK2 IL10RA STAT3 PMC5576060__F1 Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract IRS4 MTOR IRS1 PMC8675856__F7 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer CYP4F3 TAF5L CYP4F8 PMC8675856__F8 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer CYP4F3 TAF5L CYP4F8 PMC4865098__F7 Circadian rhythm pathway regulated by CTV-B2, CTV-B6 and CaLas-B232 PRR9 ELF3 PRR7 PRR3 PMC5642448__F1 Insulin signalling pathway GRB2 SHE PTEN PMC7783402__F2 Role of IIS signaling pathway in reproduction and its longevity Schematic diagram elicits that IIS is actively involved in reproductive function and lifespan in C GRB2 PTEN PDPK1 PMC5378188__F2 Animal NLRs provide structural insights into plant NLR function NLRP3 NAIP NOD1 NLRC4 PMC7775142__F5 Synthetic gene circuits for self-regulated drug delivery systems ADAMTS5 CD2 CXCL10 IL6 CCL2 PMC10867181__F3 Hypoxia regulates the metastatic cascade TCF3 ANGPTL4 PAFAH1B1 HEL-S-28 CXCR4 HIF1A PMC8430835__F1 Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer PMC3899918__F2 Jak-STAT Signaling Pathway from KEGG (ID: hsa04630) overlaid with log2 fold change values using PathVisio indicating up (red) or downregulation (blue) following ART EPO CBL PMC6852473__F5 Comparison of central metabolic features of the Rifle comammox Nitrospira NONO PMC8406911__F8 CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/Beta-catenin signaling via CTNNB1 MMP7 LEF1 PTBP1 EIF2A CD44 VEGFA CCND1 EIF4E PMC3760419__F4 Cell Death in Disease: Mechanisms and Emerging Therapeutic Concepts TNF FADD BAX PMC4181300__F2 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes IL1R2 IL1R1 CCL2 PTGS1 IL6R NOD2 STAT5B IFNG MMP3 PLAT IL18 TLR7 MMP2 BCR TIMP3 IL10RA SELE IL10 MMP10 MMP9 IL1RN NR3C1 VEGFA PON1 ADRB2 HEL110 CTLA4 IL6 MTHFD1 THBS4 PGRMC1 THPO IL12B IL10RB IL15 VEGFC NFKBIB TNFRSF1B IGF1 HSPG2 TSHR F5 TNFRSF1A DHFR F7 IL2RA SCNN1A HSPA1A PMC7376555__F4 Schematic model illustrating cellobiose-elicited action of ER stress and lignocellulase synthesis CDT1 SEC61G SEC63 CWH43 SEC62 PMC4833515__F3 Oxysterol-Related-Binding-Protein Related Protein-2 (ORP2) Regulates Cortisol Biosynthesis and Cholesterol Homeostasis CORT CYP11A1 HSD3B2 CYP11B2 PMC4181300__F3 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes MMP10 CD14 FGF4 IGF1R IL1A LIPC REN VCAN TNF IFNG PLAT TNFRSF1B IGF1 F3 VWF NOS2 CSF1 PMC9324263__F7 Disruption of O-GlcNAcylation Homeostasis Induced Ovarian Granulosa Cell Injury in Bovine OGA TXNIP PCNA CDC42 BAX PMC10647353__F4 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis MAML3 MAML2 PMC4772349__F2 Candidate driving genetic alterations and their druggability in AYA cancers ALK CDKN2C RASA2 MSX1 POLG PTEN MTOR DDB1 FAT1 CDK6 NF1 POLE AXIN1 MDM2 CDK4 PMC5660709__F5 Mycobacterium tuberculosis interferes with phagosome maturation EEA1 VPS33B UVRAG PTPA STAT3 CD36 PMC3144426__F1 Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC10647353__F2 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis SOX2 APC PORCN SPIN1 HIPK1 SOX9 PMC4633016__F3 Schematic diagram showing the convergence of WNT and NOTCH signaling onto cell cycle regulation LEF1 RBPJ EGFR NOTCH1 CCND1 FZD1 PMC10647353__F6 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis ATM SMAD2 SMAD4 PMC4528692__F4 ΔNp63 and TAp63 TF networks SMAD2 MYC NOTCH3 CEBPB DLX3 BNC1 CITED4 TFCP2L1 IKZF1 BACH2 LYL1 E2F2 TCL1A SOX15 APP NOTCH1 LZTS1 JAZF1 TFAP2A IRX1 TCF7L1 NFYB SNAI3 IRX4 KLF15 ELL3 RUNX3 TANC2 SOX2 RUNX1 MAFF NFATC1 IRF8 VAV1 LEF1 EP300 TFEB GLI3 TP73 PMC11534180__F11 Alzheimer's disease pathway modified from the KEGG database [29] ULK1 INS MTOR INSR COX2 ATF4 LPL APP CASP9 SNCA ELF2 CASP12 TUBB RTN3 RTN4 APC ABO CDK5 NRBF2 MCU ATG101 TNF CASP3 ACD TRAF2 FADD PMC11534180__F13 PPI subnetwork of DEGs from HC and EC tissue RPL13a TUBB RPL4 SNAP25 RPS9 SYT1 PS1TP5BP1 RPL8 HEL-S-162eP PMC7492390__F2 Immunological basis of TCMR CXCR3 CXCL10 APC CXCL9 IFNG PMC3257753__F1 TWEAK-Fn14 signaling system TRAF5 TRAF6 TRAF2 PMC7492390__F3 Complement-dependent mechanisms of antibody mediated rejection HEL-S-62p CD59 VWF PMC5732752__F8 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle FRS2 GSK3B HEL-S-162eP PMC3815941__F3 Bacterial and host effector molecules with potential probiotic effects LTA TLR9 PMC11739150__F1 Structures of the insulin/insulin-like growth factor (IGF) system TSC2 BAD IGF1 IGF2 GRB2 SHE PMC5732388__F3 Key downstream genes were identified in the PLK1 signaling pathway PSMD12 RGCC BUB1B NCAPG MYC NEK2 KIF20A ZWINT PMC8773933__F2 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy SRC SP1 TF PMC8773933__F3 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy BAD APAF1 BIK BAX PMC6102046__F6 CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response ATF4 EIF2A CNPY2 PMC5394057__F1 Cellular mechanisms of radioresistance: (I) the cell cycle checkpoint signaling pathway is a critical progress that allowing times for cells to response to repair DNA damage ATM CD44 ABCG2 CDH2 ATR PMC6678780__F4 Protein network analysis of the overexpressed genes in the TLR non-responsive patient cells MYL6B MED12 BABAM1 UBL5 RBBP4 BCL7A MIS18BP1 RNF19A ARID2 BMI1 PCNT ZNF521 NKTR USP24 ANKRD36C MYST4 SMARCC1 EXOC7 CBX2 SIAH1 FBXW9 COMMD3 KLHL3 WDR33 ASXL1 MYL5 ILF3 ZNF219 EZH2 PHIP AF1Q MZF1 SNRNP200 BRWD1 ANAPC1 MDC1 DDB1 CHD8 SMARCD1 SETD2 NUMA1 ANKRD36 CHD9 PMC5732752__F9 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle FRS2 GSK3B CCNB1 HEL-S-162eP PMC6804569__F4 Metabolic control of T helper cell differentiation IL2 HEL-S-133P PMC2912031__F4 Reciprocal inhibition mechanism by TGFB and IFNG STAT1 SMAD2 TGFBR1 TGFBR2 PIAS1 SMAD4 IFNGR2 JAK1 IFNGR1 SOCS1 PMC1175050__F1 NFKB pathway regulates inflammation, dendritic cell (DC) development and function, and thymic selection and regulatory T cell production FOS RELB TRAF6 CD40 MYD88 TNF JUN PMC7414992__F1 LT biosynthesis is part of metabolism of the omega 6 polyunsaturated arachidonic acid (AA), which is cleaved from plasmamembranes by phospholipase A2 (PLA2) GPR17 LTA COX1 LTB PMC4291618__F7 IAV facilitates bacterial adherence through the activation of the TGFB signaling pathway SMAD2 SMAD4 TF PMC4466627__F1 Ghrelin receptor controls obesity by fat burning COX2 GHSR UCP1 PMC8040901__F2 Involvement of the autophagy pathway in the phospholipids of exosomes from LnCap cells (Lipid Pathway Enrichment Analysis, LIPEA) ATG12 DKFZp686F0183 PMC8040901__F3 Lipid Pathway Enrichment Analysis (LIPEA) has shown that the autophagy pathway is involved in the phosphorylation of exosomes from PC3 and DU-145 cells GPX4 LPCAT3 STEAP3 FACL4 GC HEL-S-64p ADA SLC3A2 IPP TF CP PMC6893734__F6 Schematic representation of the regulation of the autophagy-lysosome system in response to severe energy deficit and its modulation by exercise ULK1 ATG12 CTSO ALG13 AMBRA1 BCL2 DLD DKFZp686F0183 PMC3949417__F1 Sensing of transferrin-bound iron and regulation of hepcidin expression in hepatocytes SMAD4 HFE SMAD1 TF DKFZp781O1323 PMC8367056__F4 Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy LATS1 LATS2 PMC9409255__F3 Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer ATF4 EIF2A ERO1A RPAP2 PMC317132__F1 Model of somatic sex determination in C SDC1 SDC2 TRA2A SDC3 PMC11641594__F9 Protein–protein interaction (PPI) performed by Ingenuity pathway analysis (IPA) HIF1A STAT1 SERPING1 ERG PDCD5 ADAR TRIAP1 TMEM97 HEY2 LRRTM2 TMEM109 PHACTR2 DACT3 CCNL2 SAMD11 TNS1 APC2 GAS2L3 MEF2C TLE2 FOXH1 COBL APOA4 SMAP OLFM1 ARMCX1 PEAK1 MYL2 EGFR RPL27 KDELR2 TLN1 PDZRN3 OPTN MAD1L1 ITIH4 AMER2 ITIH2 SERPINC1 ENDOD1 MESD SLAMF8 RPS2 ANKZF1 LGALS7B GZMA CCND1 F11 CADPS CAMSAP3 GJB1 TCIM ALMS1 TAF8 YPEL3 TAF1 TRIM29 FOXA2 RELA PXN STAT3 PMC11641594__F7 Apelin signaling pathway with differentially expressed proteins (DEPs) PDE3B SMAD4 KLF2 NOTCH3 PMC11641594__F8 WNT signaling pathway with differentially expressed proteins (DEPs) ROCK2 BAMBI INVS RNF43 CBY1 STOM APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA RBX1 NLK PMC4480315__F1 Homocysteine metabolism PMC11641594__F5 Human papilloma virus infection pathway with differentially expressed proteins (DEPs) BAD TRADD STAT2 EGFR APC SCRIB IRF3 PTEN OASL TBP ATM CDK2 GRB2 TYK2 ATR FADD TERT PMC11641594__F6 HIF-1 signaling pathway with differentially expressed proteins (DEPs) EDN1 TLR4 EPO VHL PFKL TFRC HEL-S-87p MTOR HEL-S-133P TF STAT3 HEL-S-162eP PMC1201344__F4 Fasting effects on fatty acid composition FAT2 FAT1 FAT3 FAT4 PMC3077393__F8 GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin B Gene TSHB TRH PRL GATA2 PMC9286923__F4 Metabolic Landscape in Osteoarthritis SIRT2 NAMPT ADAMTS5 MMP9 MYC PARP1 PTEN MTOR SOX9 HEL-S-68p MMP3 SIRT7 ADAMTS4 MMP12 PC BMPR1A NOS2 SIRT1 PMC5835092__F4 Ingenuity Pathway Analysis for the interaction between Jab1/COPS5 and PD-L1 STAT1 CASP3 COPS5 S100A8 RELA GSK3B PARP1 TYK2 TNF HIF1A JUN STAT3 PMC5835092__F5 Ingenuity Pathway Analysis to predict the effect of chemical drugs on level of Jab1/COPS5 COPS5 NFKB1 SMAD4 PARP1 JUN TXN STAT3 PMC7258638__F1 Can respiratory syncytial virus (RSV)-dependent necroptosis be targeted for therapeutic benefit? Simpson and colleagues demonstrate that RSV infection readily induces necroptosis in RSV-infected airway epithelial cells HMGB1 RIPK1 TLR4 IL33 RIPK3 NACA2 IL25 TSLP MLKL GATA3 PMC9025423__F1 Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia FANCD2 FANCM FANCL FANCA FANCB FANCE FANCG FANCF PMC4225589__F5 Plasmalogen-Biosynthesis Pathway and Associated PhenotypesPlasmalogen synthesis is a multistep process that involves several enzymes GNPAT PEX7 FAR1 PMC4751407__F1 Disc in Flames: Roles of TNFA and IL-1B in Intervertebral Disc Degeneration TRADD TRAF1 TRAF3 TRAF2 FADD PMC5835092__F3 Ingenuity Pathway Analysis (IPA) for Jab1/COPS5 regulation network in cancer NCOR1 EGFR SMAD4 PTEN IL6 HIF1A TXN NFKBIA NFKB1 COPS5 BCL2 JUN STAT3 PMC4666639__F6 Fn14, a Downstream Target of the TGFB Signaling Pathway, Regulates Fibroblast Activation SMAD2 SMAD4 PMC3656404__F1 Signaling pathways involving PKR-mediated inflammation and immune regulation HMGB1 NLRC4 ATF2 EIF2A IRF3 TNF AIM2 PMC9604018__F7 Pharmacological and Therapeutic Applications of Esculetin DGAT2 FOXO1 FASN PMC8616597__F3 Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling CRY2 ADRB2 PER1 PMC5292181__F5 Functional interaction network analysis by GeneMANIA of candidate mouse and human genes related to brain metastasis SLC7A11 MSR1 UCN TPH2 FKBP5 TMEM150B PLLP TNLG2B PTPRQ RDX ATAD2 THOC7 TTC28 SLC8A2 POLE2 TIMELESS POLE TNFRSF4 MCM2 SLC25A13 VCAM1 CXCR4 HTR2A CXCL12 PMC4145387__F2 E-cadherin regulated signaling pathways involved in gastric cancer MMP7 LEF1 EGFR CD44 ARHA RHO RAC1 TNF CDC42 PMC4468369__F7 Illustration for the mechanism underlying s-IL-15RA–induced EMT, migration, and invasion of human RCCs GSK3B SRC PMC4339202__F6 Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients GPT2 LYST HEL-S-5 PMC7352628__F7 CIGB-300-mediated effects on T-ALL cells IL7R JAK3 PTEN JAK1 PMC6467053__F2 Signal Transduction pathway for STAT3 STAT1 EPO JAK1 STAT3 PMC4326486__F4 Proposed model is that CD146 promotes angiogenesis and mesenchymal cell migration in melanoma DVL2 ATF3 PMC185249__F3 Sprouty is a rapidly inducible negative regulator of fibroblast growth factor (FGF) pathway signaling FRS2 GRB2 SPRY2 PMC7980828__F4 Flavivirus; entry, life cycle, and immune system interaction: (A) Flavivirus infections are generally transmitted through the bite of an infected mosquito or tick STAT1 IRF7 IRF3 IFNA2 FURIN SOCS1 PMC185249__F4 Signal transduction in the Transforming Growth Factor B(TGFB) family pathway is finely regulated at many levels EGF NODAL RHO SKI TNF PMC8762717__F9 PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature NLRP3 IL1B PMC5884924__F9 White adipose tissue browning through reducing tenascin C inflammatory signaling NLRP3 TNC TLR4 HOXA5 SMAD1 BMP4 PMC6731062__F3 Proteins in the glycolysis, tricarboxylic acid, and oxidative phosphorylation pathways examined by the Ingenuity Pathway Analysis software TH ADA COMP SDHD SDHA SDHB PMC3534995__F2 Canonical pathway representing LPS/IL-1-mediated inhibition of RXR function obtained by IPA from the analysis of HT29 data set CYP2B6 CD14 PAPSS2 TLR4 LBP PMC4697050__F3 Signaling pathway of BDNF BAD GRB2 PMC3534995__F3 Canonical pathway representing NRF2-mediated oxidative stress response obtained by IPA from the analysis of SW480 data set MAP3K1 EPHX1 KEAP1 FOSL1 GCLC MAPK7 GSK3B MAPK14 MAP3K7 MAP2K5 MAP3K5 RBX1 MAF MAP2K1 ATF4 RAF1 JUN PMC2947266__F10 The signaling transduction pathway leading to tPA induced fibroblast proliferation GSK3B CCND1 PMC4496222__F7 Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development EGFR GRB2 PMC4003867__F1 Emerging role of Interleukin-22 in autoimmune diseases STAT1 TYK2 JAK1 STAT3 PMC8517511__F2 CBX7 is Dualistic in Cancer Progression Based on its Function and Molecular Interactions APC HDAC2 BMI1 JARID2 EZH2 PMC8602812__F3 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites CD163 CD80 ACLY CAD PMC8602812__F4 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites TH CD80 ACLY CAD ROS1 CD36 PMC6975965__F4 ERBB2 signaling depicting actionable targets ERBB2 ERBB3 EGFR MTOR PMC3756346__F2 Map of the molecular mechanisms of apoptosis NAIP BAD TRADD CASP9 CASP10 DIABLO HTRA2 FADD PMC9484255__F4 Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response CGAS ATM ATR ARID1A PMC9237231__F4 Regulation and Modification of GSDMD Signaling in Diseases RIPK1 TRIM21 FADD GSDMD NINJ1 PMC4090452__F2 Integration of the proposed pathways by which the NTPDase5/mt-PCPH acts on the neoplastic progression PTEN MTOR PMC7515865__F3 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers BAD EIF4E MTOR PMC7515865__F1 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers TSC2 TSC1 BCR PTEN RHEB PMC4070062__F3 Cytosolic nucleic acids sensors and autophagy ESX1 CGAS IRF3 PMC4070062__F1 TLRs and autophagy FER TLR7 TLR4 TLR9 NOD1 IRF7 MYD88 NOD2 PMC3971994__F1 HGF/Met receptor signaling pathway HGF GRB2 PMC3858246__F1 Canonical WNT/Beta-catenin signaling and inhibitors LEP APC PMC8640016__F8 FUT8 negatively regulates NFKB2 signaling by blocking the activation of TNFR FUT8 BCL2A1 NFKB2 TNF FADD PMC8947839__F4 Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review MMP9 IL1B FOXO1 PMC5259907__F2 The network of cell apoptosis regulation induced by DNA damage ATM ATR BAX PMC5259907__F4 Network constructed based on CASP3 ATM EGFR MYC CASP9 CASP8 FADD FOXO1 BAX PMC7687032__F3 Blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity TREM1 SYK MTOR APOE PMC3510123__F7 Eliminating the SLAC1 anion channel affects K+ channel activity, K+ uptake, and the rate of stomatal opening through its impact on and as predicted by the OnGuard model (; ) CRH MAL PMC3652804__F1 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity PIK3R1 IRS4 INS PTEN IGFBP5 IRS1 PDPK1 INSR IGF1 IGFBP1 IGFBP4 GHR IGFBP2 PIK3CA GH1 GHRHR IGFBP6 SHC1 AKT3 PMC5749725__F2 Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression IGF1R SMAD4 CTNNA3 GIP ARHA INSR NLK FER ERBB2 MAPK1 OTP LMO7 CTNNA2 PMC9393500__F1 Biosynthetic approaches to efficient assimilation of CO2 via photorespiration modification in plant chassis HYI PMC10932467__F2 Possible effects of IL-6 signaling on energy intake and energy expenditure under non-obesogenic conditions UCP1 ATM STAT3 PMC4508517__F4 Uses of CRY2 domains CRY2 RAF1 PMC8635802__F4 Kinase Inhibition as Treatment for Acute and Chronic Graft-Versus-Host Disease TH PLCG1 APC PMC2911016__F1 “Go upstream, young man”: lessons learned from the p38 saga MAPKAPK2 ATF2 PMC2921576__F1 Schematic representation of hepatic methionine metabolism HEL-S-61p HEL-S-182mP NNMT PMC5508527__F2 Metabolic reprogramming and tolerance during sepsis-induced AKI SIRT6 TNF SIRT1 PMC6001073__F5 The gene or protein expression of GLUT1, HK1, PGM1, UGP2, GALT, GALE, SLC35A2, LALBA, and B4GALT1 on the lactose synthesis pathway throughout lactation LALBA GAL B4GALT1 PMC5508527__F3 Metabolic reprogramming and tolerance during sepsis-induced AKI TSC2 TSC1 STAC SIRT6 TNF SIRT1 RHEB PMC5988853__F2 Interplays of interleukin-23 (IL-23), IL-6, signal transducer and activator of transcription 3 (STAT3), and retinoid-related orphan receptor Gt (RORGt) in the differentiation of pathogenic T helper 17 (Th17) cells CCR6 CCL20 TYK2 STAT3 PMC8160894__F6 TAK1/AP-1-Targeted Anti-Inflammatory Effects of Barringtonia augusta Methanol Extract TLR4 MAPK3 CCL2 MYD88 PMC6608034__F3 MTORC1 pathway: effect on TLR signaling cascades and modulation by bacteria TSC2 TSC1 MYD88 STAT3 PMC3073693__F4 Molecular pathways in dystonia THAP1 EIF2A PMC11880140__F2 Roles of five types of decidual innate immune cells in the regulation of labor initiation and PTB RAG1 PMC7265991__F1 Intersection of radiation and the tumor immune microenvironment HMGB1 CGAS CD36 PMC3328908__F9 Diagram of canonical tight junction signaling pathway HEL-S-11 CASK PTEN PMC3670239__F1 Infection-induced IL-10 and JAK-STAT STAT1 CD14 SOCS3 TYK2 JAK1 SOCS1 STAT3 PMC8422077__F2 Depiction of genetic dependencies in cancer EGF BRAF EGFR VPS4B VPS4A PMC8834883__F1 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions ULK1 ATG12 ATG3 ULK2 MTOR DKFZp686F0183 PMC8001445__F4 Metabolomic map of flor yeast gluconic acid consumption PC GIP CIT MAL PMC8834883__F3 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions ATG16L1 ATG12 PTEN MTOR ATG14 DKFZp686F0183 PMC6529190__F10 Adiponectin-mediated signaling pathway in HSCs ADIPOR1 ADIPOR2 PTEN DNMT3B APPL1 PMC7662373__F1 The hypoxia pathway under normoxia and hypoxia VHL TF STAT3 PMC6027421__F2 Steroid biosynthetic pathway CYP11A1 CYP17A1 CYP21A2 PMC8427689__F6 Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment MYB BAD SHE PTEN RAC1 BRCA1 MATK TSC2 BCR GRB2 SYK GAL RBL2 CD19 PMC11747879__F2 Activin signalling pathway SMAD2 SMAD4 FSTL3 PMC4156532__F9 Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1 TBK1 ULK1 KEAP1 SESN2 PMC11894105__F2 Molecular mechanisms of apoptosis pathway activation TRADD FADD BAX PMC4942281__F2 Oncogenic survival signaling components in PCNSL IL10 IRAK1 MYC MYD88 CXCL13 BTK PIM1 TLR4 BCR BCL2 JAK1 IL4 CXCL12 STAT3 PMC11894105__F3 TNF-induced necroptosis signaling pathway TRADD TRAF5 CYLD TRAF2 FADD MLKL PMC7023707__F1 Kynurenine pathway and tryptophan metabolism in the central nervous system HEL-S-90n KYNU KMO PMC12183064__F6 Molecular mechanism of ERA36-mediated protection against HG-induced apoptosis and senescence CASP3 PTEN EZH2 BAX PMC6426753__F1 Complement pathways HEL-S-62p CS CFH C1S CR1 CFI PMC3890654__F1 Toll-like receptor-4 signaling pathway CD14 TLR4 FOS SIGIRR IRAK2 TRAF6 MYD88 JUN SOCS1 TAB3 MAL PMC3890654__F2 Negative regulators of toll-like receptor-4 signaling pathway by Lactobacillus jensenii TL2937 in porcine intestinal epithelial cells and antigen presenting cells CD14 TLR4 FOS SIGIRR TNF JUN TAB3 MAL PMC7865493__F1 Aryl hydrocarbon receptor (AhR) signaling pathways: canonical (A) and noncanonical (B) AHR EGFR STC2 IL22 IL6 KLF6 IL1B PMC11894105__F5 Molecular mechanisms and regulatory networks of ferroptosis GPX4 LPCAT3 STEAP3 FACL4 HEL-75 TF PMC7865493__F2 Molecular interactions within the AhR signaling pathway AHR FLG CYP1A1 OVOL1 HMOX1 NQO1 PMC6620896__F3 Conceptual model of cellular processes within Tv ARX SAT2 PMC12160515__F2 Possible signaling pathways in inflammatory-oxidative stress mediated neural regeneration BAD KEAP1 PTEN BDNF PMC3393719__F8 Yeast Magmas Ortholog Pam16 Has an Essential Function in Fermentative Growth That Involves Sphingolipid Metabolism PHB2 SAP30 PMC6027492__F2 Mitochondrial protein lipoylation LIPT2 LIPT1 LIAS GCSH PMC4459582__F7 Kruppel-like factor 5 is required for perinatal lung morphogenesis and function BMPR2 ACVR1 PDGFRA BMP2 ACVR1C KLF5 TGFBR2 AMHR2 SEMA3B FGF18 PTGS1 FGFR2 PMC4905194__F2 Mechanisms of gap filling POLE RAD51 RMI1 RAD18 PCNA PMC4828451__F5 Complement activation pathways HEL-S-62p CD59 C9 MASP1 FH C7 C6 C4A CR1 PMC6549747__F1 Signaling pathways implicated in different categories of breast cancer KIT IGF1R FGFR1 APC EGFR LRP5 GRB2 LRP6 MTOR PMC6549747__F2 Interaction between tumor microenvironment components, including stromal cells, and tumor cells leads to enhanced cell growth, proliferation, angiogenesis and invasion CYP3A4 MYC CCND1 CDK4 FUS CDK6 PMC4682245__F5 DEGs involved in JNK pathway in Tg(RE:HSE:EGFP) MAX FLNA ATF2 JUND MEF2C PMC4772696__F3 Role of EZH2 in genomic signaling through canonical and non-canonical activity SUZ12 TF EED PMC3819741__F2 Identification of the genes in the MAPK signaling pathway that harbor or are in the close proximity of SNPs associated with feed efficiency SPR CD14 NGF DAO MAX HEL-S-11 ATF2 ECSIT JUN PMC4084561__F2 Regulation of type I interferon responses STAT1 STAT2 CXCL9 TYK2 IFNAR2 SIN3A JAK1 IFNAR1 IRF-1 MX1 STAT3 PMC4084561__F3 Regulation of type I interferon responses STAT1 AGO2 STAT2 SYK TYK2 JAK1 TNF USP18 PMC2842130__F9 Redoxosomal signaling for IL-1B and TNFA pathways TRADD TRAF6 HEL-S-44 IL1R1 MYD88 TNF TRAF2 PMC3236512__F2 Effect of FXR activation on triglyceride and cholesterol metabolism in the liver PCSK9 APOB VLDLR ABCG8 ABCG5 LPL LDLR PON1 TG NR1C1 HMGCR PMC8654299__F1 CoQ biosynthetic pathway of plant and the coexpression network COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 IPP PMC3151543__F2 Schematic depiction of how complement modulates T-cell immunity HEL-S-62p APC BCL2 CD40 CD80 PMC4505959__F10 The molecular events leading to the production of IL-10 in macrophages exposed to S EGR1 TLR4 NFKB2 FOS ACO2 ADPGK NDUFA10 MYD88 TIRAP PMC2924648__F3 Directed cell migration PAK1 APC EGFR PTEN DOCK2 PMC7644914__F1 The underlying molecular mechanisms influencing the protein synthesis, degradation, and dynamic trafficking processes of ASIC1a NGF BDNF IL1B PMC3513219__F2 XRCC1 is instrumental in base excision repair (BER) of small oxidative lesions and a related mechanism for the repair of single-strand breaks (SSB-R), both caused by ionizing radiation OGG1 PNKP PMC12174687__F3 Nectin-4 signaling in normal and malignant cells CXCR4 TIGIT CXCL12 CDH2 PMC6217754__F1 IL-32-induced signaling pathway activation in macrophages COX2 CXCL1 IL16 CXCL2 STAT3 PMC7820759__F4 Schematic view of the molecular network and functions of human papillomavirus (HPV) E5, E6, and E7 oncoproteins in HPV-induced cancers HLA-E CARM1 E2F4 E2F6 FOXM1 EGFR CDK6 PRMT1 CDK2 OGT CDK4 KDM6B NHERF1 STAT3 PMC4867367__F4 GR cross talk with the TLR signaling pathway TBK1 TANK GRIP1 IRAK1 IRAK2 TRAF3 TRAF6 HDAC2 IRF3 IRAK4 MYD88 MAL PMC5777349__F9 SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis APLN IL6ST CCL2 STAT3 PMC6949885__F15 Molecular mechanism by which miR-601 downregulation inhibits the proliferation, migration and invasion of PCSCs by activating KRT5, and subsequently inhibiting the Wnt signaling pathway WNT1 GSK3B PMC5296320__F2 Schematic representation of the role of pancreastatin (PST) in the regulation of insulin secretion from pancreatic beta cells GC GOPC GCK PMC4867367__F5 Cross talk of GR with the STAT signaling pathway SRC STAT3 PMC6103460__F1 Major Nai influx and efflux pathways and metabolic pathways involved in ATP supply CPT2 MCU NACA CD36 PMC5932189__F3 Myeloid C-type lectins and heterologous receptors CARD9 MDM2 SYK MYD88 MTOR IRF-1 PMC8830302__F1 Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy CTLA4 LAG3 HIF1A IFNG FOXP3 PMC6430726__F7 Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway BCL2 PTEN PMC3532179__F1 Mathematical model of the apoptotic pathways induced by cisplatin CASP3 CASP9 ATR BAX PMC8000754__F4 Proteasome inhibitors and metabolic pathways NAMPT ATF4 HIF1A HEL-S-133P SIRT3 PMC11120609__F1 Metabolic pathway of cyclophosphamide CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC9389016__F7 Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder DAO MAOA AMY1A GAA PYGM PMC11552210__F2 Molecular pathways involved in the increase of fibrosis in the ovary and uterus by exposure to micro/nano plastics HMGB1 TLR4 MMP2 SMAD2 MMP9 PMC3978192__F2 Pathophysiology and pharmacology of hepcidin HFE IL6R SMAD1 DKFZp781O1323 TFR2 STAT3 PMC6306333__F5 Proposed working model IL16 CXCL8 IL1B PMC6982102__F2 Ceramide is the central molecule in sphingolipid metabolism and can be synthesized by three different pathways: de novo synthesis pathway, sphingomyelinase pathway and salvage pathway KDR DES CERK SMS PMC3575845__F7 Anti-quiescence network mediated by the Myc-miR-22 pathway TP53INP1 HMGB1 CARF MXD4 MYC PMC8025348__F2 Main mechanism of F EGR1 TLR4 TIGIT TNF IL1B PMC5111721__F3 NAD+ metabolism is compartmentalized SIRT2 NAMPT NMNAT1 SIRT4 SIRT5 SIRT6 NMNAT2 SIRT1 SIRT3 PMC4695008__F6 Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2A/androgen receptor signals CXCR4 VHL CCL5 PMC1952649__F2 Two tales concerning skeletal muscle IGF1 IGF2 PMC11760605__F2 This diagram represents a schematic overview of the MAPK pathway, comprising three principal activation branches: RTK, ERK, JNK activation nodes STAT1 MAPKAPK2 ATF2 GRB2 MAPKAPK5 IL6 MAPKAPK3 RAF1 PMC8208723__F10 Root meristem size reduction and stem cell death in response to DSBs PIN1 ATM PIN4 PMC8102120__F1 Pyroptosis: A New Frontier in Kidney Diseases NLRP3 IL16 AIM2 GSDMD PMC3538647__F1 Metabolic map of the purine biosynthetic pathway PURA PURB PMC6688195__F1 Key intrinsic immune evasion mechanisms exploited by HPV oncoproteins in keratinocytes (KCs) STAT1 CGAS TLR9 CD1D STAT2 IRF9 TRAF3 HEL-117 EZH2 ME3 CXCL14 HDAC1 PMC5935098__F3 Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye SOX2 NF2 RPE PMC8380402__F10 NCAPG promotes the progression of lung adenocarcinoma via the TGFB signaling pathway SMAD2 NCAPG SMAD4 CDH2 TF PMC3882710__F8 The potential role of MuRF1 in atrophy induced gene expression pathways PNPLA3 PIK3R1 ENO3 c-fgr COL1A2 MEF2C HEL-S-133P MYOG CHRNG PMC3674015__F1 (A–C) Schematic overview of particle-based vaccines CD40 PMC8908994__F2 Noncoding RNAs in Cardiac Hypertrophy and Heart Failure MFN2 IKBKE HOXA9 PLEKHM1 MYD88 GATA4 PMC4305955__F1 Fibronectin-related signaling pathway graph stored in HBVPathDB CSK SRC RHO PMC3248179__F2 Evi1 forms a bridge between the epigenetic machinery and signaling pathways TSC2 PDK2 PTEN RHEB PMC4331626__F4 Depiction of various pathways that are known to contribute to eEF2K regulation in systems biology graphical notation (SBGN) activity flow format () TSC2 EEF2K TSC1 EEF2 PMC8298820__F2 Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19 HMGB1 ACE2 PMC9367289__F1 Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy SUFU SHH SMO PMC5903825__F1 Hepcidin regulation and action in non-cancerous tissue ERFE HFE TFR2 PMC4128256__F7 Models of Ras signaling in NF1-deficient GBM cell lines NF1 PTEN MTOR PMC2593023__F1 Unexpected pieces to the senescence puzzle BRAF EBP IGFBP7 IL8RB PMC4598780__F1 DNA damage response activates cell cycle checkpoint WEE1 ATM TOPBP1 ATRIP MDC1 GADD45A CDC25B ATR H2AX PMC5325323__F3 Neural tube closure: cellular, molecular and biomechanical mechanisms HP BMP2 SHH ARHA RAC1 CLDN4 SMAD1 DKFZp781O1323 PMC8156813__F5 Sildenafil Alleviates Murine Experimental Autoimmune Encephalomyelitis by Triggering Autophagy in the Spinal Cord MTOR BDNF DKFZp686F0183 PMC8998017__F1 STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments CGAS ENPP1 IL6 PMC9103444__F3 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer MCL1 BAX PMC6385449__F13 miR-506 inhibited the expression of LHX2, which hampered TCF4 expression and inactivated the Wnt/Beta-catenin signaling pathway, consequently inhibiting tumor growth and metastasis in NPC TCF4 PMC11673094__F7 Targeting to insulin resistance is illustrated and summarized TLR4 TRAF6 MYD88 IRS1 PMC9103444__F8 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer CDK12 PMC5944225__F9 Magnoliae Cortex and maize modulate Porphyromonas gingivalis-induced inflammatory reactions COX2 IL1B STAT3 PMC11673094__F5 Targeting to maintain mitochondrial function is illustrated and summarized MFN1 MFN2 PARP1 SIRT1 OPA1 PMC10490091__F7 Anti-Inflammatory Effect of Meriania hexamera Sprague by Targeting Syk Kinase in NFKB Signaling TLR4 SRC SYK MYD88 PMC11673094__F3 Targeting to attenuate the inflammation is illustrated and summarized NLRP3 TLR4 TRAF6 NOX4 TXNIP MYD88 MYDGF HEL-S-31 IL1B ACSL3 PTX3 PMC11673094__F4 Targeting to attenuate the ROS is illustrated and summarized NOX4 GLP1R SIRT3 PMC11673094__F1 Potential molecular pathways of fatty acid, especially PA-induced vascular endothelial dysfunction, are illustrated and summarized—PA uptake by endothelial cells through fatty acid transporter or passive diffusion MFN1 NLRP3 CYR61 MFN2 TLR4 TRAF6 NOX4 PARP1 MYD88 IRS1 PTX3 OPA1 PMC8684233__F3 Ferroptosis in urologic malignancies HEL-S-102 PANX2 GPX4 MTOR PMC5022081__F1 Post-translation processing of Klotho protein CS ADAM10 ADAM17 PMC8660617__F9 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CDC20 RASSF1 PLK1 ATM CDC6 CDK2 BRCA2 APC PTEN CDC2 ATR SKP2 PMC11673094__F2 Targeting to attenuate the programmed cell death is illustrated and summarized NLRP3 SIRT1 PTX3 PMC3338196__F3 Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation PC CIT MAL PMC2972986__F1 Biological processes known to be stimulated in an AHR-dependent and/or AHR-independent manner by the tryptophan photoproduct FICZ AHR CYP1A1 PMC3839581__F1 Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release PXDNL ARFGAP3 TUBA4A MAP2 PPFIBP1 MYO1C ARMC10 KIFC1 INS DST DMXL2 PXDN GIP ARHGEF2 PFKM DMD PLAT NAGA IGF2 APC PFKL DNAJB11 C2CD2 IQGAP1 HAPLN4 ATXN2 TUBA1B PSMD2 PSMD1 ERC1 CLASP1 CLASP2 PMC4963802__F1 Wnt signaling pathway RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC11475825__F4 IPA analysis of the signaling networks between AhR signaling and NRF2 signaling EP300 AHR CDKN1A CYP1A1 CYP1A2 PMC1774670__F2 Interaction of JC virus (JCV) T-antigen with key growth regulatory pathways MDM2 CCND1 IRS1 PMC10310980__F1 Circadian clocks in cancer: Mechanisms and clinical implications CRY1 CRY2 GC CD44 MTOR CRYZ BAX PMC5547743__F7 Proposed model for I-SMAD-regulated signaling that enhances HSPG expression, cholesterol uptake and HCV entry BMP6 VLDLR ALK EGFR SMAD6 LDLR BMP7 CD81 PMC1774670__F6 P53 pathway MDM2 PCNA BAX PMC11475825__F2 Actin mechanism of the NRF2 signaling pathway BMP6 GCLM GPX4 SOX2 GCLC IL6 HIF1A ABCB6 JDP2 KLF4 NOTCH1 HEL-S-44 UGT1A1 PMC4257089__F1 In silico modeling of a CD4+ T-cell EGFR TGFBR1 PTEN INSR ITK BTK AQP3 BCL10 PLD2 NEU3 NGFR PTPN1 PTPN11 APP SRC BMX GJB2 CAV2 PTPN6 CSK PTGS2 LCK GRB2 RAF1 SHC1 LAT CDC42 PMC9250486__F4 Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited MTOR PMC5571780__F1 Small GTPases in endothelial barrier regulation ARHA ARHGAP29 RADIL RASIP1 PMC5869671__F1 NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival RELB CD40 LTBR GBF1 FBXL15 PMC2945208__F1 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS CDK2 CDK6 PMC2945208__F3 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS SOX2 CDK2 E2F3 CDK6 PMC1959234__F1 Schematic model for the "error-free" BRCA double strand break repair pathway Brief overview of components within the BRCA pathway used here as a working model that was tested here CHEK2 ATM BRCA2 RAD50 MRE11A BRCA1 PMC11703838__F2 Signaling pathways in TCSCs KDM1A MAML1 KIF7 SOX2 SUFU APC GLI3 SMO STAT3 PMC8722734__F3 Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases MCM6 KLLN FOXO3A DEDD FOXO1 PMC5474494__F2 Phagocytosis mediated by receptors PIR SYK IRAK4 CDC42 PMC5301133__F4 Protein interactome involved in neuroendocrine neoplasm proliferation.Proliferative signaling includes a tightly regulated signaling interactome (including RAS/RAF, MAPK, and PI3K/Akt) BRAF MAP3K11 DKFZp781B1423 EGFR TGFBR1 TGFBR2 PTEN MTOR CDKN2A NF1 MDM2 MAPK1 JUNB FOS VIPR2 RRAS MAP2K2 AKTIP HRAS RRAS2 MAGED2 TSC2 RICTOR TSC1 RASSF1 MAP2K1 PIK3CA JUND AKT3 PMC2867937__F12 Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues ST14 ST13 PMC5301133__F2 Mechanistic basis of secretory regulation in a neuroendocrine cell ADORA2A CCK DRD1 DRD2 ADCYAP1R1 PMC11703838__F5 Crosstalk between TCSCs and immune cells SIRPA CD47 SIGLEC15 WNT3A CCL15 WNT1 IL6 CCL2 CSF1 STAT3 PMC7268289__F7 Pathway bar plot explanation and pathway map explanation BAD CTSK PIR TRAF6 IRAK4 IRF3 PTEN EIF4E TNF MTOR TLR3 RHEB CASP3 BCR LBP EIF4B FADD TIRAP PMC8580862__F9 Immune-Related Molecular Profiling of Thymoma With Myasthenia Gravis E2F4 SMAD2 MYLIP MYL1 SMAD4 CDK7 CDC45 CDC20 SMC3 CDK2 CD7 MDM2 CYC1 PCNA STAR SKP2 PMC6025837__F6 Thyroid hormone signaling pathway RXRB TSC2 BAD MDM2 CASP9 PFKFB2 PTEN MTOR RHEB RXRA PMC8870356__F1 Integrins in Modulating Smooth Muscle Cell Plasticity and Vascular Remodeling: From Expression to Therapeutic Implications EGFR GSK3B SRC PMC5664393__F7 B-cell activating factor (BAFF)-BCR crosstalk in chronic lymphocytic leukemia (CLL) cells BTK BCR LYN RELB SYK TRAF2 STAT3 PMC6775706__F1 Cyclin D-CDK4/6-INK4-Rb pathway in breast cancer CCNA2 CDC6 CDK2 CCND1 ORC1L CDK4 CDC2 CDK6 PMC6775706__F2 Signaling pathways associated with tumorigenesis and combined treatments that alleviate drug resistance CDK2 EGFR CCND1 CDK4 MTOR IRS1 CDK6 BMP4 PMC6437095__F2 Interaction between miRNAs and TGFB pathway in GC SMAD2 GC FSHR PMC6437095__F3 Interaction between miRNAs and FSH pathway in GC GRB2 FSHR LHCGR MTOR BDNF AKT3 PMC6437095__F4 Interaction between miRNAs and apoptosis pathway in GC MAP3K1 BAD IGF1 NGF TRADD SMAD2 GC TNF TRAF2 FADD SIRT1 PMC11931041__F2 Diagram of the PI3K/AKT/mTOR (PAM) signaling pathway TSC2 RICTOR TSC1 KEAP1 PDK2 PTEN DEPTOR NDFIP1 MLST8 PMC4645220__F13 Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway LIMK2 LIMK1 MMP2 MMP9 PMC8859176__F10 Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation EZH2 BDNF KDM4A PMC5633884__F7 Elevated expression of Par3 promotes PCa metastasis via Hippo pathway inactivation TWIST1 FRMD6 PMC12252150__F2 Molecular mechanism of ERF3, SR4, DRM6-1, CHL1, NRL1, PM1, DMP2 and their role in resistance to P NRL SWAP70 PMC9414081__F10 Research progress on extraction technology and biomedical function of natural sugar substitutes LDLR TRPM5 HMGCR PMC9414081__F11 Research progress on extraction technology and biomedical function of natural sugar substitutes CPT1A GSK3B FASN PMC11555290__F2 Decoding tumor-fibrosis interplay: mechanisms, impact on progression, and innovative therapeutic strategies AREG EGFR IL33 PMC12025727__F5 Signaling pathways activated by AEG-1 in HCC CTBP2 LEF1 APC EGFR MYC IL6 PTEN STAT3 PMC11555290__F1 (By Figdraw, ID: RASTR41933) Mechanism of fibrosis promotion by malignant tumors: Tumor cells secrete pro-fibrotic factor TGFB and activate CAFs through the TGFB/Smad signaling pathway SMAD2 SMAD4 PMC12025727__F3 Mechanisms by which AEG-1 induces MASH TRAF2 NR1C1 FASN PMC8433920__F5 Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities BAD FOXO4 MMP9 EGFR RAC1 MTOR SUZ12 CDK6 MMP2 CDK2 SRC CDK4 CDC2 EZH2 PCNA CDC42 BAX PMC5201051__F7 Schematic depiction of aspects of adult olfactory GBC regulation SOX2 OMP ASCL1 NEUROG1 SMAD2 BMI1 HES1 PMC4926504__F1 Signaling mechanisms of epidermal growth factor receptor (EGFR) transactivation in renal fibrosis SMAD2 EGFR SRC PMC5742019__F1 Metabolic Strategies of Melanoma Cells: Mechanisms, Interactions with the Tumor Microenvironment, and Therapeutic Implications BRAF SHMT1 NRAS MYC PTEN MTHFD1 HIF1A MTOR PHGDH HEL-S-26 ACLY HK2 GLS FASN PMC7945361__F6 Proposed relationships of amphotericin biosynthesis with relevant metabolic pathways in S DAP CIT MAL PMC6063915__F2 PPAR Signaling Pathway and the Terpenoid Backbone Biosynthesis Pathway PLK1 EBP DHCR24 IDI1 CPT2 HSD17B7 TM7SF2 UBB GGPS1 CYP7A1 CYP51A1 ACOX1 ACAT1 FDPS LPL SQLE MVK HMGCS1 HMGCR RXRA PMVK MVD FDFT1 EHHADH MSMO1 ACADM PMC6063915__F3 LSEC and KC signaling pathways in 3DHLK systems FACL4 DHCR24 NR1C1 HMGCR CYP7A1 ACAT2 ACOX1 ACSL6 PCSK9 ACSL5 CYP27A1 CYP8B1 ACAT1 FCER1A ACADS GAB2 FDFT1 LDLR ACSL3 EHHADH APOE ACADM PMC3423502__F6 Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud SPRED3 TBX6 DKK1 PMC1679905__F6 Signalling routes emanating from the epidermal growth factor receptor (EGFR) EGF EGFR GRB2 SHE PMC3589096__F2 SREBP activation and input from mTORC1 signalling SREBF2 PMC3897773__F7 Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling APP SRC IPMK PMC209288__F1 The biosynthetic pathway for the fibrillar collagens expressed in skin, identifying steps that are affected in different forms of EDS COL3A1 COL1A2 COL1A1 PMC3661399__F7 Selected AMPK and IGF-IR signalling pathways relevant to this study in normal (A) and hyperglycaemic (B) conditions TSC2 MTOR IRS1 PMC9556450__F2 Drug transport across the blood-testis barrier F5 RPS6 CDC42 PMC3295081__F1 Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models TLR4 MYD88 JAK1 PMC9505027__F1 MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases E2F4 IRF7 IL13 DKFZp781B1423 IRAK1 SMAD2 PDK2 GSK3B TRAF6 PTEN RAC1 TNF MTOR CDK6 STAT1 COX2 IGF1 NFKB1 MDM2 MAPK1 CDC2 SP1 PMC8669491__F3 Altered protein secretion in Batten disease CTSA CLN3 TPP1 HEL-S-130P PMC8035226__F2 Metabolism of multiple substrates supports acetyl-CoA production in the fat cell ACSS2 ACLY FASN PMC10778207__F4 Src intracellular signaling pathway and various cellular processes controlled by each pathway GRB2 SRC ARHA MTOR STAT3 PMC5552707__F8 Network analysis of the gene pathways* catalogued in the Panther database, which - directly or indirectly - are connected with AD upon activation with Hp(2-20) MAPK8 MAPK3 GSK3B NRAS PLCG2 PDPK1 FRS2 NOTCH1 SRC ARPC1B PPP6C NEK1 APOE ACTR2 PRKCI FPRL2 ADAM9 MAP3K1 PRKCQ SOS2 PSEN2 FPR1 ERBB3 PRKX FPR2 LRP6 PPP4C TCF7L2 CTNNA1 EIF4E IFNAR1 APBB2 SOCS6 WNT10B EIF4G1 FZD5 ARPC4 ACTL8 ARHG MAPK13 ARPC2 ARPC3 RPS6KB2 PKN2 LRP11 IKBKE BRAF PRR5 MAP2K4 RASA2 PTEN ADAM17 PLD2 APP JUN RBPJ SPRY4 NFKB1 RELA PIAS1 REL PMC10886920__F1 Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma STAT1 MMP9 RAF1 MTOR AXL STAT3 PMC3447932__F10 Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding OTX1 VSX2 PMC3438665__F1 p53-dependent and -independent therapeutic strategies for cancer cells MDM2 PRIMA1 MTOR PMC10379333__F3 Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots TSC2 CCL2 ABCA1 MTOR PMC7593515__F2 YAP/TAZ by core components of Hippo signaling pathway NF2 LATS1 AXL LATS2 PMC6620386__F8 microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1 MTOR PMC8683078__F2 Biofactoid data is connected to information sources and establishes a bridge between related pathways PML SUMO3 SUMO2 UCP1 ATF2 SENP1 ACSS2 PAH HDAC1 SIRT3 CDKN1A SIRT5 HEL-S-11 CDC2 CSA2 CRTC1 MEF2C JUN MGA NR1D1 GLUD1 SUMO1 PMC3513366__F1 Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells PI3 MSI1 BRAF DCLK1 HP APC CD44 TG STAT3 PMC7593515__F3 Hippo signaling pathway and potential inhibitors of YAP/TEAD HEL-S-62p AMOT GRB2 LATS1 RHO LATS2 IRS1 BRD4 PMC8124199__F2 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension STAT1 TYK2 JAK1 STAT3 PMC8124199__F3 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension MMP9 HEL113 PMC5944149__F2 The overexpression of tRNAs regulated the progression of cancer acting on different ways: Ras, c-myc and TERT promoted the transcription of tRNA genes by binding to pol III ERBB2 ERBB3 TERT PMC6815315__F3 GSK3 regulates cell death, renewal, and differentiation IGF1 APC MCL1 IRS1 PMC7667862__F9 Model for OTUD7B deubiquitination of TRAF3 and inhibition of NIK to suppress LCL161-induced lung cancer cell invasion and migration OTUD7B TRAF3 RELB CD40 PMC9291723__F1 Ferroptosis in Acute Kidney Injury GPX4 LPCAT3 FACL4 FTH1 DPP4 ALOX15 NQO1 TF BAP1 PMC6815315__F1 GSK3b and growth regulation IGF1 APC MTOR IRS1 RHEB PMC8514750__F4 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases SUMO3 SUMO2 CDC2 SIRT1 SIRT3 PMC8514750__F5 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases OMA1 OPA1 SIRT3 PMC8226626__F1 JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms STAT1 EGF IL13 IL11 TYK2 JAK3 IL6 IL31 IL4 STAT3 PMC3414439__F4 Combinatorial Drug Discovery Using Transcriptional Response Modules CASP3 PRKCA CAV3 MAPK3 SRC MAP2K3 TOP2A KCNE1 GNAI1 PMC3677821__F2 Schematic showing some major pathways implicated in cancer progression using Drosophila studies CSK MYC SRC SCRIB COMP PMC8924142__F1 Type I interferon-mediated tumor immunity and its role in immunotherapy STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 MTOR IFNAR1 PMC8924142__F2 Type I interferon-mediated tumor immunity and its role in immunotherapy HMGB1 TBK1 CGAS TLR9 IRF7 UNC93B1 DDX41 IRF3 MYD88 TLR3 ZBP1 TICAM1 CLEC9A TLR4 SLC19A1 PMC1193534__F1 Comparative Genomics of Natural Killer Cell Receptor Gene Clusters DAG1 LCP2 KIR2DL1 VAV1 GRB2 SRC PTEN PTPN6 SHC1 LAT PMC4691064__F5A Transcriptomic Response to Nitric Oxide Treatment in Larix olgensis Henry RPS5 FRK HEL-S-11 PMC7316979__F3 Interaction networks from significantly upregulated serum cytokines from cancer survivors EGF PLAUR CXCL5 MMP9 DPP4 ENG TFR2 VCAM1 GDF15 PDGFA opn GC CRP IL1RL1 CCL17 RBP4 FGF19 CD40LG hEMMPRIN CXCL12 TFF3 BDNF PECAM1 CHI3L1 PMC9460763__F5 Impaired autophagy with augmented apoptosis in a Th1/Th2-imbalanced placental micromilieu is associated with spontaneous preterm birth ATG3 DKFZp686F0183 BAX PMC3625555__F3 Neuroactive ligand-receptor interaction and calcium signaling pathway PLN BCR TRH EZR MCU CAV2 LPA PTGDR PMC8666534__F5 Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer KLF2 PTEN EZH2 FGF7 PMC6932950__F1 An overview of current and emerging agents for TNBC therapy PTCH1 DHFR SHH SMO CDK4 MTOR BRCA1 PMC7593950__F5 Simplified scheme of putative role, function, and involvement of VEGF, PlGF, and IGFBP-3 in signaling pathways described in angiogenesis and tumor growth PLCG1 PIGF MTOR CDC42 PMC9261367__F6 T-Cell Aging-Associated Phenotypes in Autoimmune Disease NOTCH4 RAB5A RAB11A PMC7017752__F3 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) NF1 KIT CSF1 PMC10136628__F1 Metabolic pathway of tetrahydrobiopterin (BH4) TH DHFR PAH PMC7280434__F1 Current strategies to overcome multidrug resistance SHH SMO PMC3834778__F4 Shear stress reveals the mechanisms by which OA induces PICs and MMPs in human chondrocytes TLR4 PLK1 PLK3 PMC3834778__F5 Networks of shear stress-induced OA progression IL1B BAX PMC7017752__F2 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) NF1 RIN1 GRB2 MTOR PMC2712453__F5 Erb-associated signaling pathways BAD PC BCR MTOR PMC8699595__F2 Abscission Checkpoint: A Guardian of Chromosomal Stability ATM INCENP CHMP4C CHMP4B CEP55 PMC2712453__F6 TLR-mediated innate immune signaling pathway TLR9 IL1R1 MYD88 IFNG TLR8 TLR7 TLR4 IL10RA IL10 TLR5 IL1A IFNB1 IL6 TNF TLR1 CD8A IFNAR1 TLR10 TLR3 HLA-A TNFRSF1A LCK SYK IL6ST CD80 JAK1 FADD PMC6770077__F1 Pathway shows the influence of adipocytes on cancer ADIPOR1 COX2 ADIPOR2 IGF1 LEPR IL6 MTOR IL6R IRS1 SLC31A1 INSR PMC2712453__F7 Signaling pathway inferred from a gene regulatory network FAR1 RFWD2 CDC42 BET1 PMC8178558__F1 Innate type 1 immune response, but not IL-17 cells control tuberculosis infection TBK1 CGAS DDX41 IRF3 PMC2712453__F2 G1-phase signaling pathways inferred with different heuristics SWI5 CIB2 CDC20 PMC2712453__F3 S-phase signaling pathways inferred with different heuristics FAR1 CDO1 CDC6 CDC45 PMC10518420__F3 An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment IFNG PMC8253500__F4 Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression COL4A3 SLC2A4 TCF7L1 PMC3234318__F1 OB inhibition by MM cells IL7 HGF IL3 BMP2 IL27 CCL3 PMC5531462__F6 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer FGF2 EVI1 FGF9 PMC3882682__F8 Canonical pathways HEL-S-62p BTK TLR4 BCL10 CD180 SYK RAC1 CR2 BLK CD81 CD19 PMC5531462__F4 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer c-fgr FGF2 EVI1 GRB2 PLA2G4C FGF9 PMC2706303__F2 Bioelectric mechanisms in regeneration: unique aspects and future perspectives PTEN SOX10 PMC7757044__F1 Roles of related miRNAs during the phases of autophagy ULK1 ATG12 ATG3 LAMP2 AMBRA1 ATG101 ULK2 ATG10 MTOR DKFZp686F0183 UVRAG STX17 VAMP8 SIRT1 VAMP7 PMC4189469__F1 Schematic illustrating mechanism for expression and function of regulatory genes for development of the oviduct and for development of epithelial-derived ovarian cancer A2M opn SERPINB3 TF SERPINB11 PMC3033586__F2 Wnt pathway and its regulation of Beta-catenin in stem cells and cancer APC CD44 CCND1 GPR49 PMC7702481__F5 Dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs CD58 PC GC PMC9606746__F1 Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway COX2 GSK3B PTEN MTOR BAX PMC6736714__F8 Gli phosphorylation code SUFU SMO PMC10295080__F1 Nrf2 signalling pathway GCLM KEAP1 PMC8670931__F5 Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound NFE2 MAPKAPK2 EMX2 EYA2 SDC1 CDH11 MBP HSPA2 ETV4 PMC10244678__F9 Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway NLRP3 FGF19 WAPAL PMC4118478__F1 p53 at the crossroads of MPN treatment STAT1 STAT2 MDM2 TPO TYK2 JAK1 MTOR PMC7691375__F1 Comparison of mouse and human pro-resolving macrophages IL16 TLR4 TLR9 ARG1 IL1B PMC8928416__F4 NOD1 and NOD2 in inflammatory and infectious diseases ATG16L1 NOD1 ATG12 IRF7 TRAF3 IRF3 HSPB8 RIPK2 TRAF2 DKFZp686F0183 NOD2 MAVS PMC11908617__F4 Effect of ZNFs on CRC metastasis‐related pathways [46, 47, 51, 52, 55] ZNF276 ZFP57 ZNF460 ZNF384 ZNF326 DKFZp572F2170 PMC4072689__F5 Hijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae IFIT3 IFIT2 STAT2 IRF7 IRF9 MX1 LIMA1 HINT1 EIF3S2 EIF3K MAP1B PXN IFIT1 PMC5299128__F6 Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea ATOH1 PMC8838402__F10 Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2 PLG ANXA2 NOX4 PMC4127876__F1 Diagram depicting hypothetical mechanisms by which the polycystins directly affect gene transcription and regulate the cell cycle STAT1 GIG8 CDK2 PMC6681802__F1 Pharmacokinetic and pharmacodynamics pathways for mycophenolate mofetil UGT1A9 CES2 CYP3A4 UGT1A10 IMPDH1 IMPDH2 UGT1A8 UGT2B7 ABCC2 UGT1A7 PMC8083963__F1 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease EGFR SNX3 SNX27 WLS PMC8083963__F2 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease VPS35 F2 F3 VPS29 PMC6987486__F2 Mechanisms of how Sfrps modulate cellular apoptosis, angiogenesis, differentiation, inflammatory process, and cardiac remodeling IL10 SFRP4 BMP1 LEF1 WNT3A HGF CCND1 TNF PMC4435778__F5 Meiotic recombination SPO11 DMC1 RAD51 PMC12005559__F2 Cholesterol metabolism and transport pathways LPL LDLR PMC12005559__F3 Anchor model of female steroidogenesis, describing the estradiol synthesis pathway, its regulation, and perturbation by dioxin HSD3B1 CYP11A1 HSD17B1 CYP17A1 PMC3463457__F1 Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells CDKN1A CDKN1B PRB1 MAPK1 MTOR FOXO1 CDK6 PMC3674226__F3 Where No Synapses Go: Gatekeepers of Circuit Remodeling and Synaptic Strength ARHA PTEN MTOR PMC5233484__F1 The canonical and non-canonical autophagy pathways ULK1 DKFZp686F0183 PMC4557770__F1 B cell receptor (BCR) signaling pathway and molecular interactions in the CLL microenvironment CXCR5 CCL4 MTOR BTK BCR VCAM1 CXCR4 LYN CCR7 CD40 SYK CXCL12 CCL3 PMC8549879__F1 Hepatic LC3 II/I Ratio Is Not Modulated in Exercised Mice ATG12 ATG3 BCL2 ATG14 DKFZp686F0183 PMC9189063__F3 IFNB basal expression through TLR4/TBK/IRF3 pathway TLR4 IRF3 PIGS PMC10949727__F3 FOXO3a regulating EMT and drug resistance in breast cancer SIRT6 MDM2 CDK6 SKP2 BRD4 PMC8185863__F2 Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma AGO2 SMAD2 APC SMAD4 DKK1 UHRF1 PMC6158482__F1 Neutralization of the interleukin-12/interleukin-23 pathways associated with T-cell activation and differentiation TH IL23R IL12RB1 PMC5358800__F1 Myelodysplastic syndromes: updates and nuances BCOR HEL-S-26 PRC1 RUNX1 ASXL1 ZRSR2 EZH2 STAG2 TET2 PMC11706994__F8 LCWE-induced ALI NLRP3 TLR4 IL6 MYD88 PMC11615488__F5 Map of phospho-proteins in cellular signaling pathways that regulate YPP expression in mosquito fat body NUMB ATG12 ATG3 SCRIB PTEN MTOR RHEB TSC2 RAB1A RICTOR MTMR3 TSC1 KIAA0226 ATXN1L ZYX BCL2 UVRAG PMC4214761__F5 Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma PI3 CTSK TFRC CD74 PMC7700615__F2 Signaling via TGFB receptors initiated at different intracellular locations and sites of inhibition by RAC1B SMAD2 SMURF2 SMAD4 SRC SMURF1 TF PMC4158461__F7 The underlying mechanism of CFE on the TLR4 signaling pathway IL16 TLR4 MYD88 IL1B PMC9420733__F6 Signaling pathways in obesity: mechanisms and therapeutic interventions CCK POMC NPY AgRP MC4R MC3R MC2R PYY ARC PMC3142564__F3A Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer ERBB2 EGFR MTOR PMC9420733__F2 Signaling pathways in obesity: mechanisms and therapeutic interventions POMC IGF1 NPY UCP1 AgRP BMP7 PZP PTEN Nucb2 IRS1 PMC9420733__F3 Signaling pathways in obesity: mechanisms and therapeutic interventions RET POMC NPY UCP1 ALK GDF15 AgRP pp6425 GFRAL ADRB3 GDF3 PMC9420733__F4 Signaling pathways in obesity: mechanisms and therapeutic interventions CXXC5 ADD1 UCP1 NOTUM LRP5 LRP6 ARHA RYK OSBPL2 STAT3 PMC8145522__F2 Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN TBK1 CGAS USP15 RBM10 IRF7 ATF2 IRF3 TRIM25 MAVS PMC9420733__F5 Signaling pathways in obesity: mechanisms and therapeutic interventions POMC NPY UCP1 AgRP HEL-S-104 BMP4 FASN PMC10949727__F2 FOXO3a regulating apoptosis and cell cycle in breast cancer CASP3 CASP9 CCND1 BAX PMC8996682__F6 Blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments NLRP3 TLR4 CX3CR1 CCR6 VCAM1 CX3CL1 CD163 MYD88 NGB BAX PMC6260991__F7 Schematic representation for hypothetical M2 macrophage-induced myofibroblast differentiation of LR-MSCs WNT7A FZD1 PMC8469180__F3 Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction GRB2 IRS1 PMC3813872__F7 Models of Eph signaling in amphid axon guidance PTEN SGK1 PMC5629631__F23 Multiple modes of AOAA’s action in cancer cells GOT2 PMC2872012__F4 Functional genetic network as defined by the bioPIXIE tool (Myers et al VPS18 RIC1 VPS72 LEO1 RTF1 VPS36 SAP30 VPS29 PMC7883806__F1 Wnt signaling pathway DAAM1 APC GSK3B LRP5 LRP6 ARHA ROR2 RAC1 ROR1 PMC2872012__F5 Detailed representation of the interactions between the components of the gene network VPS35 VPS72 VPS29 PMC6125421__F2 Signaling pathways of the unfolded protein response ATF4 EIF2A XBP1 PMC8023019__F1 Rationale for the combined use of an ICD inducer and an IDO-1 inhibitor ELF2 HMGB1 AHR APC MTOR PMC3434988__F1 Hepatocyte growth factor (HGF)–cMET axis signaling network and ongoing targeted therapy strategies HGF EGFR GAR1 RPTOR PMC7925880__F6 LREE regulates bile acid metabolism through intestinal flora HNF4A LDLR FGFR4 PMC7734567__F2 Mapping the 12 pairs of genes, which are positively correlated in all 12 types of cancer, into the tryptophan metabolic pathway AOX1 INMT DHTKD1 DLD EHHADH GCDH ACAT2 PMC6374451__F7 Schematic overview of DNA demethylation during glioma progression PIK3R1 PI3 IGF2BP3 PIK3CA CDK4 CDKN2A CCNE1 PMC2998559__F1 Model Depicting major molecules and events in mast cell activation BTK GAB2 LYN GRB2 SYK ORAI1 LAT STIM1 PMC6779289__F2 PPI network generated for the proteins encoded by the eight statistical driver genes LIPC NCOR1 CD46 BLM EGFR TEC PLCG2 CFI ITK BTK LCP2 CFD CFH BASH DLL4 KLRK1 MICA RAD50 CD55 NCOA1 MED1 XRCC3 RAD51B NCOR2 RAD51C CFHR3 NOTCH4 RAD1 RBPJ CFB PSEN2 POLK RPA1 ITGAM APOB BRCA2 LYN SYK ATR FABP1 PMC3626710__F5 Results from single pathway sets HEL-S-49 PCM1 PGM3 PGM2 FBP1 ARG2 BST1 ARG1 PMC6889286__F2 Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer RET BRAF ALK NTRK1 EGFR FGFR3 PTEN MTOR AXL ROS1 STAT3 PMC6628002__F2 Schematic representation of physiological and pathological aspects (major sources of oxidative stress) in Alzheimer’s disease (AD) and their corresponding antioxidant defense approach by anthocyanin in cholinergic neurons CASP3 GFAP APP BAX PMC7884371__F2 The NLRP3 inflammasome pathway NLRP3 RIPK1 MYD88 TNF IL1B NOD2 FADD GSDMD PMC7929492__F1 Canonical activation pathway for the NLRP3 inflammasome NLRP3 TLR4 RELA MYD88 IL1B PMC5775519__F1 Pattern recognition receptors (PRRs) for human immunodeficiency virus type 1 (HIV-1) recognition and the following pathway for triggering type I interferon (IFN-I) expression CGAS IRF7 IRF3 MYD88 IFI16 PMC8568271__F5 Interleukin-1 activation of NF-kB through Ajuba CYLD TRAF6 AJUBA PMC11125956__F11 Osteoblasts in Rheumatoid Arthritis Pathway RUNX2 GSK3B SMAD4 IL11 DKK2 COL1A1 BMPR2 opn SRC CSNK1A1 SP7 BMP2 APC SMAD6 PTH DLX5 IL6 TNFRSF11B TNF WIF1 SMURF1 BGLAP DVL1 SMAD9 ALPL WNT3A IGF1 AXIN1 BCL2 APC2 CSF1 SMAD1 TGFB1 DKFZp781O1323 PMC5775519__F2 Type I interferons (IFN-I)-initiated signaling pathway leading to interferon-stimulated gene (ISG) expression STAT1 STAT2 IRF9 PMC9099669__F2 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective VPS35 SNCA PINK1 SYNJ1 LRRK2 HEL-117 HTRA2 PMC11125956__F13 B Cell Receptor Signaling Pathway, KEGG BLK CD81 BTK CD72 BCL10 RASGRP3 BCR BASH BANK1 GC CD22 LYN GRB2 SYK CD19 PMC11854592__F2 The EpCAM signaling pathway in cancer progression LEF1 EPCAM EGFR FHL2 ADAM17 PMC3429092__F4 TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells HEL-S-11 TRPC5 TRPC6 PMC9099669__F5 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective TNF BAX PMC7463463__F1 Amino acid metabolic pathways altered in cancer and select inhibitors targeting these pathways PAK1 GIG8 AHR AFMID RAC1 CDC42 PMC7463463__F2 Targetable vulnerabilities related to serine and 1C metabolism SHMT1 DHFR HEL-S-51e DHODH PHGDH PMC7439204__F5 Anti-ARDS pathway of YQHYJD in KEGG EGF NRG3 BAD NRG2 MYC SHE MTOR CBL GRB2 SRC TGFA NRG4 JUN PMC10975212__F1 TGFB/SMAD signaling pathway SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC3462343__F7 Model depicting how chronic exposure to SAg could elicit an autoimmune disease BCR SAG APC PMC2785474__F4 TLR4 and chemokine receptor cross-talk TLR4 IL8RB ADRBK1 PMC11987241__F8 M2Φ-exos-mediated TGFB1-induced phenotypic transformation in BEAS-2B cells SMAD2 SMAD4 PMC10975212__F5 Non-SMAD, non-canonical TGFB pathways SMURF2 SMAD6 TRAF6 ARHA RAC1 MTOR TF TRAF4 CDC42 PMC2785474__F2 TLR signaling (an example in macrophages and dendritic cells) TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 TIRAP PMC10525362__F1 Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond CYP27A1 VIT DBP CYP27B1 PMC3255783__F7 Model depicting the potential roles of Hrq1 in NER-based lesion processing REV1 XPA PCNA PMC11089204__F5 Proposed metabolic pathway of psilocybin and its active metabolite psilocin UGT1A9 UGT1A10 PMC4591813__F5 ErbB3 in RAF-inhibited mutant BRAF melanoma cells ERBB2 ERBB3 NRG1 PMC10670187__F1 LncRNA MIR4435-2HG is involved in signaling pathways for cancer progression CDCA5 SNAI1 IQGAP3 SMAD2 MMP9 CDH2 MTOR PMC3121749__F8 Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions LEFTY1 NODAL FOS CRIPTO SMAD2 LEFTY2 SMAD6 CER1 SMAD4 SKI JUN PMC4863644__F2 Glucose stimulated insulin secretion (GSIS) and suggested stimulus/secretion coupling factors PC CIC GIP PMC7128029__F1 BA synthesis and transport pathway PC ATP8B1 FGF19 CYP7A1 PMC2943748__F6 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation FOS SENP1 HDAC2 PMC10217757__F1 Specific Features of Focal Cortical Dysplasia in Tuberous Sclerosis Complex TSC2 TSC1 TBC1D7 AKT1S1 MTOR DEPTOR RPTOR RHEB PMC2759942__F5 Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity BMP2 BMP4 PMC7466447__F1 Immunoregulatory functions of TEC in the TME CGAS CXCL10 FGF2 TEC EGFL7 IFNG PMC7281325__F3 Multi-omic study identified up- and downregulated candidates in acquired trastuzumab-resistant BT-474.r2T cells compared to parental sensitive BT-474 cells IFIT3 IFIT2 BAD MARCKS FLNA AHNAK PSCA IKZF3 ARHGAP35 CTIF IFNL2 TEAD2 SMARCC1 HIRIP3 TCOF1 VSIG2 OAS2 NIPAL3 MAP4 MISP IMUP SPTBN1 ARFGEF2 DUT KRT4 MED1 MUC19 COG3 EMP1 CXCL11 PPFIBP2 BPIFB1 VAPB PCM1 TCEA3 SET DBN1 PLEC CXCL10 RS1 HEY2 MCM2 ASS1 PXN NEK9 PMC5259880__F3 The molecular mechanisms dysregulated in PD and thought to lead to DAergic neuronal cell death SNCA LRRK2 PLA2G6 FBXO7 HTRA2 PMC9221436__F4 Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment SOX2 TWIST1 KLF4 CD44 BMI1 PTEN MTOR PMC6040288__F9 Network pathway: pathway enrichment analysis was performed RTN4 FES LPL APP TNF FADD APOE PMC10945329__F9 ADSCs-Exo pathway reduces pyroptosis and improves tissue regeneration in the liver, which has been injured by ischemia-reperfusion and partial resection NLRP3 TLR4 CCND1 GSDMD PMC3047798__F3 Wnt signaling components regulate ubiquitylation SIAH1 APC PMC3187166__F1 Selected part of the central metabolism in C PTS CS ENO1 HEL-S-162eP PMC5491788__F9 Intestinal FXR and TGR5 cross-talk in the regulation of GLP-1 secretion, hepatic bile aid synthesis, glucose and lipid metabolism, and insulin and glucose sensitivity CYP27A1 CYP8B1 CYP7B1 FGFR4 CYP7A1 PMC5615985__F6 Role of the LGM2605 in preventing asbestos-induced inflammation, oxidative/nitrosative cell damage, cell injury, and cell death proposed mechanism of asbestos-induced inflammation and oxidative/nitrosative stress and the protective effect of LGM2605 NLRP3 HMGB1 IL16 IL6 TNF PMC3047798__F1 Ubiquitin-mediated regulation of the core Wnt pathway components APC, Axin and Beta-catenin USP15 SIAH1 APC LRP5 LRP6 TNKS PMC3142070__F4 Cause and metabolic consequences of fatty liver APOB SHBG DGAT2 ELOVL6 NR1C1 PMC4718179__F4 Activation of EGC and induction of a reactive EGC phenotype GFAP GDNF CD80 SOX10 SOX8 S100B NR1C1 SOX9 PMC8303222__F2 Importance of Being PI3K in the RAS Signaling Network BTK GRB2 PTEN PMC6247401__F6 Proposed role of macrophage LRP1 depicted in diet-induced inflammatory conditions TH APC LRP5 LRP6 SFRP5 PMC4897783__F8 Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4 LRP5 DKK4 PMC2692402__F1 Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis HMFN0839 DGAT1 GPAT4 PC GPAT2 DGAT2 AGPAT3 AGPAT4 LPA AGPAT5 PMC5665759__F3 Androgen‐regulated lncRNAs, SOCS2‐AS1 and POTEF‐AS1 promote prostate cancer growth SOCS2 TNFSF10 POTEF TLR3 PMC4320821__F4 Network graph showing interactions between ID2 and ID3 and their MIC-inferred ‘target’ genes regulating cell death PIK3R1 SUMO3 SUMO2 NFE2 TRADD ATF2 MYC MAP2K3 TXN SIAH1 CCND1 THBS1 SP1 JUN FOS PTGS2 ID3 CREBBP GIG8 DUSP10 MAX RELA CREM KLF4 PPP2CA BCL2 YY1 HEL113 ITGAX DUSP2 PRKCH DUSP3 IGF2R CYCS GZMH PMC3088996__F3 Regulatory role of ATM in cellular responses to DNA DSB repair FANCD2 ATM CDK2 MDC1 MDM2 RAD50 MRE11A BRCA1 PMC4184842__F6 Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFKB Inhibitor NFKBIA ZAP70 GRB2 JAK3 JAK1 HRAS IRS1 SOCS1 PMC8927800__F3 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway BAD IGF1 CASP9 CD96 MTOR PMC5795460__F1 Only the classical role of the Fanconi anemia (FA) pathway in the repair of interstrand cross-links (ICLs) is depicted, which involves highly coordinated protein–DNA and protein–protein interactions in the nucleus FANCD2 ATM FANCM FANCL FANCA ATR FANCB FANCE FANCG FANCF PMC5770079__F6 Apoptosis signaling pathway EIF2S1 CASP6 TRADD DDIT3 CASP3 APAF1 ATF4 MDM2 CASP9 BCL2 TRAF2 CASP8 FADD BAX PMC8641876__F1 Schematic depiction of the regulatory network of YAP/TAZ LATS1 LATS2 SIRT1 PMC8927800__F1 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway IGF1 MTOR IRS1 PMC6635453__F5 Proposed pathway for RQ biosynthesis in C COQ3 COQ2 COQ6 COQ5 PMC6966492__F1 Cell death pathways triggered by the temozolomide-induced DNA lesion O6-methylguanine SIAH1 HIPK2 ATM ATR BAX PMC8888891__F2 Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity? ADIPOR1 RUNX2 NFATC1 SMURF2 TRAF6 MTOR SMURF1 TRAF2 XBP1 JUN SOX9 PMC7294112__F7 Schematic to represent the proposed molecular events in DHL‐induced apoptosis in laryngeal carcinoma cells BAD PTEN BAX PMC2919149__F7 Targeting HIF activation pathway for cancer therapy UQCRB HEL-S-11 VHL MTOR PMC10028837__F1 The oxidative phase of the pentose phosphate pathway including 6-phosphogluconolactonase (Pgl), that converts 6-P-gluconololactone to gluconate-6-P TH LTA HAL FOS PURA PURB PMC7052781__F2 Metabolic coordination of macrophage activation TLR4 IFNG CD36 PMC5482192__F5 Ten differentially expressed genes between human bizarre parosteal osteochondromatous proliferation and osteochondroma enriched in the TGFB signaling pathway BAMBI E2F4 NODAL ROCK1 SMAD2 CTBP1 TGFBR1 SMAD6 SMAD4 SKP1 ARHA RBX1 SMURF1 IFNG FST SMURF2 THBS1 SP1 SMAD1 PMC7332497__F3 Cytosolic and sub-cellular engineering of yeast for isoprenoids biosynthesis ADA IDI1 IPP PMC3659771__F1 Notch signaling in the vasculature NOTCH2 MAML1 NOTCH4 RBPJ DLL4 JAG2 LFNG NOTCH1 MFNG DLL3 NOTCH3 PMC7952454__F3 DNASE2A deficiency causes an accumulation of phagocytosed dsDNA as well as nuclear dsDNA transported by autophagy into endolysosomal compartments CGAS TLR7 TLR9 IRF3 MYD88 PLD4 PLD3 AIM2 IL1B IFNG PMC3659771__F2 Notch signaling in the vasculature FOXC1 VEGFA NOTCH1 FOXC2 EPHB4 PMC6186458__F1 BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis FADD BAX PMC9686795__F1 Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives PINK1 ULK1 LRRK2 AMBRA1 ATG101 ATG14 FIS1 NBR1 PMC5705532__F1 Signaling involving TLR2 and TLR4 in strenuous and moderate aerobic exercise IL10 TLR4 MTOR STAT3 PMC2360544__F2 Novel therapeutic targets and proposed mechanisms of androgen resistance (text in red) in hormone refractory prostate cancer ADAR MTOR TMPRSS2 PMC9478452__F1 Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction IGF1R LIF APC RELB TRAF3 MYC TNF DEPTOR MLN TSC2 COX2 RICTOR TSC1 IGF1 CYLD CDK2 GRB2 CCND1 CD40 TRAF2 LTBR STAT3 PMC6205911__F1 Post-squalene cholesterol biosynthetic pathway and examples of malformation disorders associated with defects at specific steps DHCR7 EBP DHCR24 CYP51A1 PMC4064721__F1 Scheme of participation of MC1R in regulation of melanogenesis DKFZp686L0365 MGRN1 ASIP MRAP MC1R ADRBK1 PMC4765532__F2 BMP signaling pathway including microRNA regulation BMP2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC4064721__F2 Scheme of the impact of MC1R on development of melanoma BRAF NRAS SRC MC1R SDC2 PMC4765532__F3 Wnt signaling pathway including microRNA regulation COL3A1 LRP4 APC SOST LRP5 LRP6 COL1A1 PMC8648396__F10 Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine Beta-coronavirus-induced neuroinflammation TIMP1 HEL-S-67p RELA HMOX1 PMC8395092__F2 Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes BCR APC CD80 PMC4986885__F3 SRSF1's roles in transformation in breast cancer RRM1 RRM2 BIN1 MYC PMC5620176__F9 LncRNA ANCR down-regulation promotes TGF-Beta-induced EMT and metastasis in breast cancer HDAC3 RUNX2 PMC3840000__F1 A Potential Benefit of Albinism in Astyanax Cavefish: Downregulation of the oca2 Gene Increases Tyrosine and Catecholamine Levels as an Alternative to Melanin Synthesis DCT TYRP1 SLC24A5 PMC8597301__F8 Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis TLR4 MYD88 PMC6320319__F1 Schematic summary of the Wnt signaling derangements and the different traits of metabolic syndrome ROCK2 LRP6 TCF7L2 ARHA HEL-S-70p SP1 TG PMC5986049__F1 Control of erythropoietin (EPO) synthesis by the oxygen sensing pathway EPO VHL PMC4797366__F3 Wnt signalling in energy balance regulation GSK3B LRP6 LEPR AXIN2 PMC7122459__F1 Molecular signaling pathways involved in astrocytogenesis CNTF BMP2 LIF NFIA SOX9 PMC3430392__F1 The function of CETP in RCT.Notes: CETP mediates the equimolar transfer of CE and TG between atherogenic VLDL, LDL, and anti-atherogenic HDL LPL TG PMC7369697__F1 BRAF signaling pathway including abnormal signaling from BRAFV600E mutated proteins BAD BRAF ARAF PMC11134594__F2 TGFB signaling pathway: Integrins release TGFB by binding to LLC on ECM SMAD2 SMAD4 PMC7065707__F4 Cell cycle in stem cell proliferation, pluripotency and differentiation SOX2 CCND1 RBL1 CCNE2 HES1 PMC7065707__F2 Cell cycle in stem cell proliferation, pluripotency and differentiation SOX2 CDK2 CDC2 RB1 PMC3281554__F2 Possible mechanisms of regulation of DP thymocytes by multiple factors RORC ID3 PMC11892258__F3 Mechanism of immunosenescence promoting tumor occurrence and development CXCR1 NAMPT SYK SIRT1 PMC5192802__F2 Roles of nucleus PRDX1 in the H2O2‐induced apoptosis BAX PMC6928143__F5 Wnt signaling pathway was involved in NFPA NPPA HEL-S-11 ATF2 APC ARHA CDC42 PMC6928143__F6 ERK-MAPK signaling pathway was involved in NFPA BAD MOS MYC GRB2 SRC EIF4E CRK PXN PMC3590201__F1 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations EGF DAO NFIB FLNA ATF2 TNF NLK MAX CYC1 ECSIT BDNF MEF2C JUN PMC4097957__F1 TLR4 signaling pathway TBK1 TLR4 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR3 TAB3 MAL PMC4770718__F1 PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response TBK1 CD14 MAPKAPK2 STAT2 NFAT5 HEL-S-28 IRF8 TAOK3 MAPK3 TRAF6 MAP2K2 IRF3 MYD88 MAP2K3 TNF HEL-S-31 DKFZp686L0365 STAT1 IKBKB MAP2K1 NFKB1 MAPK1 PMC9130030__F1 Realigning the LIGHT signaling network to control dysregulated inflammation CD160 BTLA LTBR PMC6928143__F3 PI3K-AKT signaling pathway was involved in NFPA TSC2 BAD HEL-S-28 GRB2 CDC37 PTEN EIF4E MTOR RHEB HEL-S-69p PMC4146642__F7 ABeta(1-42) oligomer-induced oxidative stress PIN1 CA9 PMC7692354__F1 Near-infrared (NIR)-triggered photothermal action in MDA-MB-231 and MCF7 cell lines: the illustration shows irinotecan hydrochloride (IT) on-demand release from irinotecan-loaded biotinylated carbon nanodots (CDs-PEG-BT/IT) by means of hyperthermia ATG3 TRADD TRAF3 RIPK3 DKFZp686F0183 RIPK1 TRAF5 APAF1 CYLD TRAF2 FADD MLKL TRAF4 PMC6928143__F4 mTOR signaling pathway was involved in NFPA RICTOR ERG RHO RPS6 EIF4B RHEB HEL-S-69p PMC8151911__F2 Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review GEM GC TRAF6 STAT3 PMC11056900__F1 Molecular mechanism of mitochondrial dysfunction modulating the relationship between chronic liver disease STAT1 NLRP3 CGAS IRF3 MCU BNIP3 SIRT3 PMC11056900__F2 Endoplasmic reticulum dysfunction modulates chronic liver disease ATF4 EIF2A XBP1 IL1B PMC11056900__F3 Mitochondrial and endoplasmic reticulum-associated signaling regulates the molecular mechanism of chronic liver disease MFN1 MFN2 ROS1 PMC6169299__F8 Signalling pathways in the TLR response TBK1 CD14 IRF7 IRAK1 CXCL10 TRAF3 IRF3 CCL5 CCL4 MYD88 TLR3 TLR8 TLR7 TLR4 CXCL9 CD40 CD80 CCL3 PMC7990044__F3 Genetic modifications designed to address xenograft injury mechanisms HLA-E SIRPA CD47 APC GAL PMC8549681__F1 Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway RUNX2 LATS1 LATS2 PMC8389838__F5 Targeting Small GTPases and Their Prenylation in Diabetes Mellitus PAK1 RALA ARHA RAC1 TBC1D4 IRS1 CDC42 PMC7210546__F4 Possible cross-regulation of RAS and TLR4 in mediating the inflammation of DN TLR4 MYD88 PMC7210546__F1 TLRs and signaling molecules on the basis of literatures TLR8 TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TIRAP PMC7210546__F2 TLR4 signaling pathway in the DN on the basis of literatures TLR4 TRAF6 IRF3 MYD88 TIRAP PMC4323418__F7 Map of central carbon metabolism highlighting CceR and AkgR targets CIT TNLG7C MAL PMC5481839__F6 DOT1L safeguards cartilage homeostasis and protects against osteoarthritis LEF1 PPARGC1A DOT1L SIRT1 PMC7073516__F2 Fast and slow routes to break-induced telomere synthesis RFC1 RFC2 MND1 RAD51 POLD3 PCNA RFC3 RFC4 PMC10605176__F3 Noble gas-induced neuroprotection TLR4 HEL-S-44 BAX PMC6536925__F6 Relationship of the three diseases at gene, pathway, module, and function levels and the biological mechanism of T2DM, CML, and PCa SGCD PC MTOR PMC8087798__F8 Mechanism of POU2F2 regulates glycolytic reprogramming and GBM progression MTOR POU2F2 PDPK1 HK2 PMC10605176__F1 Neuroprotection by the volatile anesthetics sevoflurane and isoflurane TLR4 GSK3B SP1 STAT3 PMC6775191__F8 Network visualization analysis of “potential lipid markers-lipoproteins-TLR4/MyD88 signaling pathways” for anti-inflammatory effects of HLJDD SMPD2 MYD88 APOA5 CERK IL1B APOE PLA2G6 HEL-S-34 PIGS PEMT APOB LIPE SGMS1 PLA2G4B KLRB1 PLA2G1B PLA2G3 PLA2G5 SMPD1 PLA2G2F SPHK1 PLA2G12B SGMS2 PLA2G2A B3GAT1 PLA2G10 CD36 PMC7944035__F1 TLRs multiple signaling pathways NLRP3 TLR4 IGF1 SMAD2 IRF3 MYD88 SMAD1 STAT3 CD24 PMC4214202__F1 Simplified model of the potential contributions of selective sensors and cell types to IFN production during viral infections XCR1 TBK1 CGAS TANK TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 PDC TLR7 PMC11983764__F1 BCAA metabolism and tumours BCKDK PPM1K SLC25A44 BCAT1 GPRC5C BCAT2 PMC11983764__F2 BCAA hypocatabolism promotes tumour development BCKDK RAB1A CDC20 SLC25A44 BCAT1 BCAT2 RNF167 MEIS1 STAMBPL1 EZH2 ACLY PMC3249369__F4 Three MAPK pathways in yeast share common components and also contain pathway-specific factors RHO TXN CDC42 PMC5428537__F1 Meta Core pathway analysis indicated that cardiac hypertrophy signaling was significantly associated with sesamin-treated samples (P=1.148E-10) APC TRPC3 HAND1 MEF2C HAND2 GAA GATA4 PMC5514220__F2 Involvement of sirtuins in lifespan/healthspan elongation pathways NAMPT IGF1 MTOR PMC4019040__F1 Mutated and wild-type tyrosine kinase activation in cancer BTK FGFR1 BCR ERBB2 FGF2 EGFR LYN SYK PMC4093113__F2 Pathway analysis of the candidate genes APOB F2 KIN NR1C1 PMC2685579__F1 Synthetic pathways for polar lipids PC PGP PSD PMC9217774__F3 Serial Tumor Molecular Profiling of Newly Diagnosed HER2-Negative Breast Cancers During Chemotherapy in Combination with Angiogenesis Inhibitors KIT RET ATR ARAF PMC11084561__F3 Two consecutive signals are requisite for inflammasome activation NLRP3 AIM2 GSDMD PMC4394821__F1 Folate biosynthesis and utilization pathway (modified from reference ) DHFR FPGS DHPS PMC8261820__F3 Signal pathways and treatment of cytokine storm in COVID-19 STAT2 IRF7 IRF9 IRF3 MYD88 TLR3 STAT1 TLR8 TLR7 TYK2 JAK1 ACE2 MAVS PMC3883350__F1 VIP tunes immune and inflammatory response by regulating multiple signaling pathways IL10 CTLA4 TNF VIP FOXP3 IFNG STAT1 COX2 TLR4 TBP IL2 CD40 RAF1 JUNB JAK1 JUN IRF-1 PMC4963239__F4 Mediator complex: a central integrator of transcription MED17 MED12 IRF7 TRAF3 MYD88 MED23 MED15 PMC3834244__F1 MiRNA biogenesis and function AGO1 AGO2 DGCR8 DICER1 AGO4 DROSHA PMC3652852__F7 Peroxisome Proliferator-Activated Receptor (PPAR) G and PPARA Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? APC NR1C1 PMC12148668__S1 Schematic diagram illustrates the preparation of IFNG treated RAW 264 NHS GC IL1B PMC3623586__F2 Schematic model of the regulation of intestinal homeostasis by the IL-22/STAT3 pathway in IECs IL22 TYK2 STAT3 PMC9187046__F1 GSK-3 regulates PD-1 and LAG3 expression for enhanced T-cell reactivity LCK CD80 LAG3 PMC8593497__F1 Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels SCD ROCK1 LEPR TNF SIRT1 HEL-S-5 PMC7291227__F4 Ingenuity Pathway Analysis (IPA) upstream regulatory analysis CTSK MYC HDAC1 SOX9 MCM3 TBX1 TLE4 KLK3 TBX5 ASCL2 GCHFR GJB1 COL2A1 RNF39 NKX3-1 TERT PMC7291227__F3 Ingenuity Pathway Analysis (IPA) gene network analysis MYC WTAP SOX9 KLK3 JAZF1 GCHFR RPL3 TMPRSS2 KLK1 PRR3 DIS3L LOXL2 MRM3 PSMD5 RSBN1L RUVBL1 HOXA4 ZGPAT USP20 TRIM8 TIMM23 HAUS6 MYO9B RPS9 TOR1B MCAT NAALADL2 Pax9 TCP1 RPL22L1 NOL10 TFEB VGLL3 ASNS PMC5533267__F6 Glabridin on the estrogen pathway IGF1 PGR SP1 PMC4414696__F3 Simplified TAM signaling pathways in supporting cell proliferation and survival (A) and inhibiting inflammation (B) SOCS3 GRB2 SOCS1 PMC3866828__F3 HVJ-E-mediated apoptosis pathway in cancer cells CASP3 IRF7 CASP9 IRF3 CASP8 MAVS PMC4612381__F6 Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging EDEM1 HEL-S-269 ATF4 EIF2A IL6 XBP1 PMC5711482__F1 Targeting polyamine metabolism for cancer therapy and prevention SMOX PAOX PMC8295747__F2 Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis TBK1 CASP3 IRF7 IRF3 IRF-1 MAVS PMC8589328__F1 Substrate, intermediates and enzymes involved in the endogenous production and disposal of H2S HEL-S-61p VIT ETHE1 SUOX PMC10531041__F2 Stress Response in Autophagy Processes and Aging-Related Diseases BAG3 HSPB8 HEL-S-100n PMC11584093__F4 Anti-cancer signalling pathways modulated by curcumin, gingerol, and shogaol in cervical cancer cells EGFR BAX PMC7810546__F7 Compound-target-pathway network OLR1 PIG59 IKBKE PRKCZ PRKCE MPO F2R BRAF PPP3CA NR3A2 PDE3A ACKR3 TOP2A MMP3 KDR NR1i1 HEL-S-11 F2 MDM2 APP SRC EPHX2 NOS2 JUN SELE BAX KIT PTGS2 FGF2 TNF CXCR3 ALPL EP300 MMP12 F7 BCL2 SYK VCP NCF1 PRKCH HEL107 PPARG HTR2B MYLK ALDH2 TERT PMC9272595__F8 Oncogenic receptor tyrosine kinase pathway with its downstream signaling pathways and small molecule inhibitors targeting different proteins of the network EGFR GRB2 MTOR AXL ROS1 PMC11899589__F7 Schematic representation illustrating the mechanism of action of erianin in lung cancer CAD MTOR DHODH PMC4825669__F6A Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy DKK3 FOS RAZ1 BUD31 WNT9A VASN RCAN1 MYH2 MYL7 CEBPB ZSCAN20 FRZB UBC GNB3 LY6G5B MYH4 GNAO1 MEF2C STAT3 GPD1 PMC8949908__F5 Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis BAAT ACOX1 SERPINC1 LGALS3BP TIMM13 CHD6 EEF1B2 PCBP1 HMGN1 PC4 NHP2 CASP8AP2 NOP58 RPE APOA2 HOGA1 AGMAT UROC1 GSTM1 CHCHD3 HYOU1 HEL-S-162eP HEL-S-22 CNPY2 ACADM PMC10139027__F5 Scheme of LDLR activity signaling pathway for follicular development with lovastatin stimulates steroidogenesis in ovaries LDLR FSHR STAR PMC8362328__F10 Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer EGF KLK8 EGFR MTOR PMC8268639__F1 NUAK1 and NUAK2 Fine-Tune TGFB Signaling NUAK1 SMAD2 SMAD4 PMC7295848__F1 PI3K/AKT signaling cascades in cancers PC GC MYC PIK3CA PTEN PMC8133338__F1 Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy EPO CD19 PMC5732365__F1 Rho GTPases and AD pathology APP ARHA RHO RAC1 PMC1878539__F1 Unchecked thrombin is bad news for troubled arteries TFPI APC TF PMC6172470__F1 Translation acrobatics: how cancer cells exploit alternate modes of translational initiation ELF3 ELF1 SUI1 EIF2A EIF4B PMC8219921__F1 Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System SOX2 PTBP1 ZEB2 APC EGFR CCND1 PMC3674397__F2 Mechanisms of activity for sirtuins in Alzheimer's disease RARB ROCK1 APP ADAM10 PMC12155304__F4 Sinhyotaklisan as a Potential Therapeutic for Psoriasis: Network Pharmacology and Experimental Validation EGF EGFR MAPK3 ALB MYC CCL2 HIF1A HMOX1 IFNG CCND1 JUN IL1B HEL-S-89n IL1A FOS PTGS2 MMP9 NFE2L2 IL6 TNF NR1C1 CASP3 ERBB2 RELA BCL2 PPARG TGFB1 STAT3 PMC6193563__F3 Metabolic reprogramming of the tumor microenvironment by p62 and its partners NR1i1 KEAP1 TRAF6 NBR1 PMC9061988__F1 Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies CD59 C9 CS FH C6 PMC8888691__F5 Microglia and Astrocyte Function and Communication: What Do We Know in Humans? CCR5 TLR5 CCR2 TLR9 CCR3 CCR4 CD200 CCL5 CCL4 CCL2 TLR1 TLR3 CCR1 TLR8 IL16 TLR7 TLR4 CCL3 PMC8020258__F6 Osthole inhibits macrophage activation in an experimental model of asthma (schematic) IL4 ARG1 PMC4964517__F4 Upregulation of melanogenesis by SOX9 DCT SOX9 PMC9495336__F3 Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry KEAP1 SLC7A11 SIRT1 PMC6668978__F10 Schematic diagram shows the interplay of TGFB1, Notch, Shh signalling and Foxa in antler chondrocyte proliferation and differentiation NOTCH2 SHH NOTCH1 SMO TGFB1 PMC4590922__F4 The calgranulins, S100A8, S100A9, and S100A12, are secreted by cells of the myeloid lineage such as neutrophils and monocytes TLR4 S100A8 S100A12 S100A9 PMC6419612__F1 Metastatic progression in the bone DKK1 CXCL12 PMC6056224__F1 Imbalanced expression/ activity of RAD18 and Y-family DNA polymerases dictates choice of TLS polymerases and can influence replication fidelity and genome stability REV1 POLK POLN RAD18 MAGEA4 POLI PMC9577232__F6 Targeting the cannabinoid system to counteract the deleterious effects of stress in Alzheimer’s disease BACE1 GSK3B PMC6173361__F3 Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors TUBB LAMP2 HEL-S-99n NAPA HLA-B TCIRG1 TAPBP HLA-A PSMB6 CANX DNCL1 TAP2 COPE VAMP3 HEL-S-269 B2M PSMB9 PMC3795238__F8 A model depicting androgen-AR-miR-29a regulation loop IGF1 CDC42 PMC5729470__F1 Differences in pathway activation between left-sided vs right-sided CRC ERBB2 AK3 ERBB3 APC SRC TYK2 PTEN AXIN2 TCF4 STAT3 PMC8456978__F2 New insights into the molecular mechanisms of axon guidance receptor regulation and signaling HEL-S-62p ECD ADAM17 RET NRP1 SEMA3E APP SRC RGMA GDNF ROBO1 NET1 FLRT3 DCC SLIT1 LRIG2 EPHB2 EPHA4 PMC8224569__F6 Global Transcriptional Response of Aspergillus niger to Blocked Active Citrate Export through Deletion of the Exporter Gene CS CIT LCT PMC5823535__F1 Lessons from characterization and treatment of the inflammatory syndromes NLRP3 RIPK1 TRADD TNF OTULIN TRAF2 PMC7596324__F1 Mitochondria-targeted Therapies IL2 CTLA4 MTOR PMC6045629__F9 Mechanism of coagonism ITK LCK ZAP70 LAT PMC4716086__F1 Homeostasis and epidermal growth factor receptor downstream signaling pathway in keratinocyte EREG AREG EGFR GRB2 HBEGF TGFA PMC8612614__F3 Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench CRP GDNF S100B BMP4 PMC2947835__F2 Membrane proximal intracellular signals at the IS versus the HIV VS PLCG1 LCK GRB2 LAT PMC2704867__F5 Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance PDK2 EGFR PTEN PMC8219171__F5 An Examination of the Putative Role of Melatonin in Exosome Biogenesis RAB8A ATG12 ATG3 GSK3B ATG10 DKFZp686F0183 PMC8219171__F6 An Examination of the Putative Role of Melatonin in Exosome Biogenesis FZD3 CSNK2A2 PAX2 WNT1 LRP5 LRP6 MAP2K5 RYK PLCG2 DKK1 EP300 SLC2A4 TLE4 CSNK1A1 PMC6880659__F5 Proposed model of TFC pyroptosis in excessive iodine-promoted HT NLRP3 IL1B GSDMD PMC3884575__F2 Schematic representation of complement-mediated effects on T cells and APCs APC CD80 IFNG PMC12046282__F1 After CNPs enter cells through endocytosis, they induce the expression of TNFA and BMP2 NLRP3 BMP2 XBP1 STAT3 PMC3096194__F1 Cell cycle is controlled by the Rb pathway and p53 pathway CDK2 MDM2 CDK4 CDKN2A TF PMC3663521__F7 Schematic diagram illustrates the role of Dapper3 in UUO-induced renal fibrosis by regulating Wnt/Beta-catenin signaling MMP7 LRP5 DAP CCND1 LRP6 AXIN2 PMC6709804__F2 Mechanism of response mediated by M1, M2, and M4 macrophages STAT1 MMP7 IL16 TLR4 MMP12 STAT2 IRF3 JAK3 JAK1 IL4 ARG1 STAT3 PMC8415634__F1 Emerging Mechanisms of Wnt Secretion and Signaling in Development APC LRP5 ARHA RYK PMC5315281__F5 De novo assembly of the sea trout (Salmo trutta m. trutta) skin transcriptome to identify putative genes involved in the immune response and epidermal mucus secretion C1GALT1C1 B3GNT6 B4GALT5 PMC2063509__F1 AUTOPHAGY: HIGHLIGHTING A NOVEL PLAYER IN THE AUTOIMMUNITY SCENARIO IGF1 ATG3 IL4 TNF MTOR PMC8415634__F2 Emerging Mechanisms of Wnt Secretion and Signaling in Development RAB8A SNX3 PMC2491722__F4 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche RET LYN GDNF SRC PMC2491722__F6 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche RET CDK2 GRB2 ATF1 GDNF PMC7068464__F7 Schematic diagram showing that upregulation of large-conductance and Ca2+-activated K+ (BK) channel activity in activated hepatic stellate cells (HSCs) exerts an antifibrotic effect through suppressing of the profibrotic TGFB1 signaling pathway TGFBR1 KCNMA1 TGFBI STAT3 PMC5558548__F5 Sphingolipids as targets for treatment of fungal infections TH PC KDR CER1 MIP CERK SMS PMC7846556__F1 Inhibition of gasdermin D-mediated pyroptosis by necrosulfonamide, disulfiram, and dimethyl fumarate IL1B GSDMD PMC11294427__F2 S100A9 binds to Toll‐like receptor 4 (TLR4) to activate downstream pathways for biological effects NLRP3 TLR4 RHO RAC1 S100A9 MYD88 NR1C1 PMC2265304__F1 Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC11294427__F3 The S100A9‐receptor for advanced glycation end products (RAGE) signalling pathway in cardiovascular disease RUNX2 BMP2 S100A9 PMC4619615__F7 Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells CDK2 CCNB1 CCND1 CDK4 CDC2 BAX PMC11616179__F2 Liver macrophages in liver fibrosis repair MMP12 MMP9 STAT3 PMC11616179__F3 LAMs and LCMs in liver injury NLRP3 MFN2 CCR2 CX3CR1 PMC11616179__F1 Liver macrophage in the initiation and progression of liver fibrosis NLRP3 HMGB1 CCR5 LOXL2 CCR2 MMP9 CCL5 CCL2 CCR8 TNF CCL1 PMC8146072__F13 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation CASP3 BAD TNF BAX PMC7998928__F1 Detrimental role of Formyl Peptide Receptor 1 (FPR1) in CVDs progression FPR1 IL6 IL1B PMC8146072__F10 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation HEL-S-61p MTR ATF4 SHMT1 DHFR PSPH GLDC HEL-S-51e HIF1A MTHFD2 PHGDH PMC5891988__F2 ILC3s in the context of cancer LTA LTB STAT3 PMC11915259__F3 Microbiota disruption leading to an inflammatory environment TSC2 TLR4 IL6 MTOR PMC8281348__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells ANKRD1 MCC AIP TAOK3 MSC ARHA LATS1 DKK1 AXL LATS2 TAOK1 TAOK2 PMC3511325__F9 Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3 SOCS3 IL6 JAK1 STAT3 BAX PMC3279615__F3 Nucleotide excision repair (NER) pathway XPC ERCC1 XPA PCNA CPD PMC4587803__F3 NF KB signalling pathway HEL-S-62p C7 C6 C4A PMC4610626__F2 Multiple activating human natural killer (NK) cell receptors and representative signalling pathways of 2B4, NKG2D, DNAM-1 and NKp46/30 VAV3 PAK1 VAV1 ZAP70 GRB2 SRC SYK RAC1 LAT VAV2 PMC7272438__F8 Proposed model for the involvement of miR-199a-3p and CAV2 in hepatic fibrosis SMAD2 TGFBR1 TGFBR2 CAV2 PMC4709508__F3 Toll-like receptors, adapter proteins, and signaling molecules TLR8 TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TLR1 TLR3 TIRAP PMC6930809__F12 Potential mechanisms by which Meisoindigo protects against focal cerebral ischemia-reperfusion injury (CIRI) NLRP3 CD14 TLR4 IL1B PMC2771724__F3 Dopamine Receptor Signaling: Genes differentially expressed in the NAC of LE vs PDE10A PRKAG2 DRD1 DRD2 PMC2771724__F4 Synaptic Long-Term Potentiation: Genes differentially expressed in the NAC of LE vs PPP3CA MAPK1 PRKAG2 PMC6769439__F8 Possible mechanism of action underlying the protective effects of maltol against APAP-induced hepatic injury through inhibition of oxidative stress-mediated activation of the NFKB pathway and apoptosis and regulation of the PI3K/Akt pathway CASP3 TRADD CASP9 APP CASP8 FADD PMC7530368__F2 Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches CGAS RIPK3 NOX4 IL1B IFNG PMC2584809__F6 Schematic model illustrating constitutive vs TH PNMT NPY DBH CADPS SNAP25 PMC8301439__F3 IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications? NAMPT PDGFRA BCAT1 BCAT2 GLS PMC9228918__F7 ATM Pathway Is Essential for HPV–Positive Human Cervical Cancer-Derived Cell Lines Viability and Proliferation CHEK2 ATM BRCA1 PMC8616386__F2 Walking down Skeletal Muscle Lane: From Inflammasome to Disease IL10 NLRP3 TXNIP IL1B MAVS GSDMD PMC7641865__F8 The protective effects of hPMSCs on CD4+ T cells senescence FYN GCLC GSK3B NQO1 PMC9317022__F1 Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF6 IRAK4 IRF3 MYD88 NOD2 TLR8 CARD9 TLR7 TLR4 BCL10 SYK PMC5462452__F1 ROS in Cancer: The Burning Question ME1 HEL-S-26 HEL-S-44 MTHFD1 PRX PMC8616386__F6 Walking down Skeletal Muscle Lane: From Inflammasome to Disease NLRP3 ADIPOR1 GHSR TLR4 GSDMD PMC2670105__F1 IMP impedes Ras mitogenic signaling by limiting KSR1 complexes EGF BRAF KSR1 PMC3031545__F8 Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B IGF1 UCP1 PMC4905708__F2 Coinhibitory pathways in the B7-CD28 ligand-receptor family APC LRBA HEL-S-92n CD80 PMC9024145__F3 Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury PRKCI TLR4 CXCR4 UBL4A BNIP3L TUG1 CXCL12 PMC6891441__F1 Scheme of Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) function in the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway TBK1 CGAS ENPP1 IRF3 PDE12 PMC11034130__F2 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy STAT4 PTEN CTLA4 HIF1A FNTA HEL107 GGPS1 TFAM FOXO1 ICOS CD36 FOXP3 PMC4139724__F3 Functional features of gingivitis-associated microbiota FLI1 FIGN PMC6720954__F1 Upper, matrix metalloproteinase 1 (MMP1) cleavage of protease-activated receptors (PARs) result in increased Ca2+signaling MMP7 ICE1 MMP12 MMP2 IL8RB CCL7 CXCL2 IFNAR2 IFNAR1 CD74 CCR1 IFNG PMC2928401__F8 Identification of Primary Gene Targets of TFAP2C in Hormone Responsive Breast Carcinoma Cells BHLHB2 COL18A1 SCARB1 CRABP2 MYCBP2 TP63 MYC MTHFD1 IGFBP5 EPHB4 BTC PRLR UNK CD55 NCOA1 ACD SP7 SHC1 PMC8773335__F5 Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach MMP2 CD2 MMP9 MMP20 MCU IL1B LAT PMC11792030__F1 CoQ biosynthetic pathway COQ4 COQ3 COQ2 COG2 COQ5 IPP PMC7160660__F3 Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes CDS1 RUNX1 CNST MTOR FOXP3 PMC9214231__F3 Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe ATF1 MEI4 PMC10555542__F4 Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial USP15 PTEN AHR CCND1 PHIP BAX KLF15 VEGFA SNAP25 PIGR GCNT1 CRK SNAP23 HMGCR FOXD1 RAB10 PLCB4 EDN1 UPRT VAMP2 EP300 COL4A3 GRB2 PIK3CA BCL2 SESN2 PMC6986459__F1 Landscape of USP7 targets and modes of action.(a) The USP7–MDM2–p53 axis FOXO4 TRIM21 MDM2 NOTCH1 PTEN PMC7686287__F6 Schematic summary of high glucose activated NFKB pathway MMP7 MMP2 CCND1 JAK1 IL1B STAT3 PMC11034130__F3 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy STAT4 MYC LPL VHL CNST PTEN CTLA4 HIF1A FOXO1 CD36 FOXP3 PMC11034130__F4 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy GPX4 CD27 TNLG8A PTEN CTLA4 CD36 FOXP3 PMC8435685__F1 Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach DGCR8 DROSHA ADAM10 FURIN ADAM17 PMC5343780__F1 Molecular mechanisms associated with inflammatory and oxidative stress in response to chronic exposure to PM0.1 AHR KEAP1 PTGS2 HEL-S-44 PMC12245507__F4 Ferroptosis signaling pathway GPX4 STEAP3 HEL-S-64p TF GLS PMC8773522__F1 Impact of Cancer Cachexia on Cardiac and Skeletal Muscle: Role of Exercise Training IGF1 SMAD2 TNF MTOR PMC4392874__F2 Network representations of the differentially expressed genes presented in pathway analysis PIK3R1 PLCG1 XCR1 PRKCZ EGFR SMAD2 GSK3B MYC PRKAA1 MTOR CR1 PDPK1 INSR IFNG PI3 PTPN11 SRC CCND1 JUN CXCR1 CSK FOS VEGFA ARHA RAC1 RRAS2 IRS1 PLCB1 CBL RPS6KB1 DUSP10 MAP2K1 WASL ERBB2 IL2RG TNFSF10 STK4 LYN ZAP70 GRB2 NR1C2 BCL2 PLA2G2D IL11RA TNFRSF10A CSNK2B GNB1 PMC5765207__F3 Developmentally regulated signaling pathways in glioma invasion HGF SMAD2 GSK3B SMAD4 MTOR PMC9118284__F2 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways NLRP3 COX2 MMP2 TRADD MMP9 IL1B TIRAP PMC9118284__F3 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways CASP3 CASP9 FADD BAX PMC11923990__F9 Zbp1 Mediates central nervous system inflammation induced by AC via promoting macrophage inflammatory phenotypes CXCL10 CXCL9 PMC4971383__F1 Feedback loops that form the molecular clock CRY1 NAMPT CRY2 SIRT1 PER2 PER3 PMC11317487__F0 Graphical abstract and proposed pathway of rhMFGE8 administration attenuate hippocampal injury by improving neurogenesis in SAH models MFGE8 CCND1 MTOR HPCA PMC5097173__F10 Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA PIAS1 POLN RAD18 PCNA PMC10813560__F8 Heatmaps were generated to visualise the notable pathways identified as significant by DIANA-miRPath (v RARA AFP BAD PMC4345914__F2 TLR signaling pathway and modulation effector molecules TBK1 TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TAB3 MAL PMC5737877__F8 Proposed model for the regulation of BATF3 by S1P signalling in HRS cells S1PR2 SGPP1 S1PR1 SPHK1 PMC8263653__F14 Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture ADAM9 ADAM15 ASPH ADAM12 INS SRC ADAM10 PMC4142280__F4 Signaling crosstalk between the TGF-Beta-activated pathway and other pathways during EMT (according to Xu et al SMAD2 SMAD4 PMC4630008__F1 Diagram of Hh signaling in mammalian cells EGF BOC GPC3 MYCBP RAB23 BMI1 GAS1 WIF1 SUFU NRP1 MDM2 CCND1 BCL2 SMO ABCG2 ADRBK1 STAT3 ITCH PMC4350105__F7 Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer SMAD2 MYC SMAD4 TFDP2 BRCA1 STAG2 PMC4630008__F2 Different roles of Hh signaling in cancer PTCH1 SMO MTOR PMC7027144__F3 Expression profiling of proteome reveals co-expression clusters and functional modules in HCC ACADL ACADS CTSO NCAPG ZWINT MCM7 GINS1 DBF4 ACADM PMC8622975__F3 Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans CCR2 TLR4 TRADD TRAF6 IRF3 PMC2660327__F2 Network analysis using Ingenuity pathway analysis (IPA) software BAD KDR SRC BCL2 PMC1847380__F14 Signaling pathways leading to pseudohyphal growth SWI5 ACE2 CDC42 PMC1847380__F15 Signaling pathways mediating the roles of Rho1 in cell wall assembly and actin organization ROM1 HMFT1766 SIM2 PMC5377416__F11 Regulatory network construction for the overlapped genes NOTCH2 OTUD7B PTGS2 NRAS SMAD4 TRAF6 CADM2 MTAP ERBB4 HNRNPD TLN2 CFH ZNF148 COPS8 IL17A PTPRE PER1 PMC8908284__F3 Dualistic role of platelets in living donor liver transplantation: Are they harmful? HGF IGF1 CCND1 STAT3 PMC7049974__F1 Sterol reductases in cholesterol biosynthesis LBR DHCR7 DHCR24 PMC8047069__F2 Life Cycle of the Phagosome PI3 EEA1 ARL8B PMC6097257__F7 Merged network analysis from Ingenuity Pathway Analysis (IPA) software for associations among molecules related to rheumatoid arthritis, inflammation of joint, cell cycle and apoptosis EREG CCNA2 HEL-S-99n APOE GFAP HBEGF ADRB2 PTX3 IGFBP1 CXCL12 BDNF CP CILP GAS1 TUBB2A GADD45B TLR4 CXCL6 STEAP4 CELF2 GMNN MKI67 PTTG1 ARHGDIB NUSAP1 CD14 CSGALNACT1 PTGIS USP2 SDC1 ADRA2C SLFN11 MATN3 PTGS2 PTGES PTGER4 STC1 HCTP4 SKA3 LTBP1 AURKA ADAMTS15 ADAMTS14 SHOX UBE2C NFATC2 TUBB4B MLXIPL NR4A3 CD40 ZWINT PPARG PMC368431__F1 Sample view of a VisAnt application FAR1 PMC8894694__F4 Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection? TLR7 BCR MYD88 CSA2 ACE2 PMC6423593__F6 Pathview graph for the Kyoto Encyclopedia of Genes and Genomes term ‘calcium signaling pathway’ allows the visualization of the differentially expressed genes involved in this signaling pathway PLN BCR CAV3 MCU CAV2 CP PMC9022973__F2 Gal-8 on cytokine expression and secretion MRC2 CD44 TNF MTOR IL1B PMC7565128__F1 Hh pathway (inactive state and active state) and the crosstalk between Hh and EGFR pathways EGF PTCH1 EGFR SHH JUN PMC7565128__F2 Crosstalk between Hh signaling pathway and PI3K/AKT/mTOR pathway, Wnt/Beta-catenin pathway, Notch pathway APC PTCH1 LRP5 SHH LRP6 SMO MTOR JUN SOX9 PMC6171019__F1 Signaling pathway with PLD1 participation was activated in LNCaP cells in the androgen-free environment BAD PC MTOR PMC3242363__F5 The mechanism of late PC STAT1 LCK SRC JAK1 STAT3 PMC3741132__F1 Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals RFC1 MTR MTRR TYMS PMC10300409__GA1 Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response IL15 IL15RA PMC8235796__F1 Expression of Wnt and TGF-Beta Pathway Components during Whole-Body Regeneration from Cell Aggregates in Demosponge Halisarca dujardinii KL APC TGFBR1 GSK3B LRP5 LRP6 PMC6854717__F6 Mechanism scheme uncovers that CRISPR/Cas9-mediated knockout of NSD1 promotes H3K27me3 methylation and inhibits Wnt10b transcription, thereby suppressing activation of the Wnt/Beta-catenin signaling pathway WNT10B PMC7456893__F1 Canonical and the non-canonical Wnt signaling pathways ATF2 WNT7A APC WNT1 GSK3B CD44 WNT9A ARHA WNT10B COX2 WNT3 WNT3A WNT4 WNT10A WNT2B WNT5B BCL9 PMC7978298__F3 ROS induce cell death, mainly including apoptosis, necroptosis and ferroptosis TIGAR PIG59 TRADD SLC7A11 CASP9 SLC3A2 TNF FADD GLUD1 PYGL PMC7978298__F1 Primary generation and elimination mechanisms of intracellular ROS NOX3 ME1 HEL-S-26 FES NOX4 MTHFD1 RAC1 ME3 PRX NOXA1 MAL PMC7961018__F1 Canonical TGFB signaling regulates the relationship between prenatal maternal depression and amygdala development in early life SMAD2 SMAD4 TGFBR3 PMC3001241__F1 MHC class II antigen processing pathways containing P MHC2TA PMC3001241__F2 Toll-like receptor signaling pathways containing P CD14 KY TLR9 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 MAP3K7IP1 TLR3 TLR4 LBP CD40 CD80 CASP8 FADD TIRAP PMC9659230__F5A Reprograming of Gene Expression of Key Inflammatory Signaling Pathways in Human Peripheral Blood Mononuclear Cells by Soybean Lectin and Resveratrol IFIT3 IRF9 IRF-1 SOCS1 IFNG BAX PMC9159819__F1 Neurobiological Links between Stress, Brain Injury, and Disease CORT ATF4 EIF2A MTOR BDNF BAX PMC7418744__F1 Pictographic representation showing the potential role of statins in COVID-19 infection PLG HEL-S-92n TNF IFNG PMC4276888__F7 Schematic of proposed TXNIP/miR-200/Zeb1/E-cadherin signaling pathway TXNIP PMC7560959__F7 Proposed metabolic pathway illustrating OTA nephrotoxicity KEAP1 HEL-S-22 PMC4243516__F1 Signaling partners of the p75NTR MOG NGF TRAF6 ARHA LINGO1 PMC9125939__F8 NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway NFATC1 NOX4 PMC9355645__F7 Transcriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons DHDDS MVK WAS HMGCR CPD PMC3159106__F2 TLR-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent and TIR domain containing adaptor inducing interferon (IFN)B (TRIF)-dependent signaling pathways TBK1 CD14 TLR5 LTA TLR7 TLR4 TRAF6 IRF3 MYD88 TLR1 TIRAP TAB3 PMC3492958__F1 Distinct roles for AlphaB hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling PC PLIN1 LPA IRS1 NR1C1 PDPK1 PMC7834960__F3 These pathways play an important role in cell growth, proliferation, and homeostasis, thus, a mutation in anyone may cause cancer cell survival, division and metastasis SUFU SMAD2 APC EGFR GLI3 GRB2 SMAD4 SHH SMO PTEN MTOR PMC7834960__F4 Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review) KEAP1 MDM2 LATS1 FADD PMC5557756__F7 Schematic of a mechanosensitive pathway whereby low magnitude SS acts through the ER stress response pathways XBP1 and eIF2A to promote IRF-1-mediated VCAM-1 expression and VLA-4-dependent monocyte adhesion VCAM1 EIF2A XBP1 IRF-1 PMC8576642__F7 Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE-/- mice by down-regulating PCSK9 via ERK1/2 pathway PCSK9 VCAM1 NOX4 ABCA1 TNF MTOR IL1B SIRT1 PMC6945027__F5 Model for the regulation of the Hippo pathway by Vgll3 and Akap11 TEAD3 VGLL3 AKAP11 ARHGAP18 TEAD4 ARHA LATS1 ARHGAP29 LATS2 TEAD2 PMC3159106__F3 TLRs crosstalk with the phosphoinositide 3-kinase (PI3K) signaling pathway TLR4 TRAF6 MYD88 MTOR TAB3 PMC1636849__F8 Schematic summary of the signaling pathway leading to Nanog repression SOX2 ZFP42 GRB2 GATA6 PMC4582187__F7 Model describing the modulation of MLP quality control at the proteasome by BAG6 and SGTA UBL4A TPR BAG6 SGTA PMC4101967__F2 Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs ISG15 STAT2 IRF9 TYK2 IFNAR2 IFNAR1 KPNA1 PMC8710575__F1 Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer PAH TGFBI STAT3 PMC5474518__F75 Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3B Signaling Pathway CH25H BAD GSK3B PMC8724616__F1 IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity IGF1R IGF1 PMC8904924__F1 Updated Review on Ozone Therapy in Pain Medicine IL10 IL7 KEAP1 IL13 IL2 IL6 IL4 NQO1 PMC6757020__F10 Illustration of pathway signalling where phosphorylation signalling PTMs have been sequenced and annotated in melanoma tumours from patients BCL2 CDK4 MC1R SOX10 MTOR CDKN2A PAX3 PMC5671526__F8 Schematic representations of potential mechanisms of PEBP1 in enhancing inflammatory response and neuron apoptosis after I/R injury HEL-S-34 IL6 IL1B PMC4423995__F1 Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration NTN1 DCC RYR2 NFATC3 CACNA1A CACNA1C PMC4282344__F1 Pathways implicated in Alzheimer's disease (AD) PSEN2 CR1 CLU SLC24A4 CELF1 SORL1 ZCWPW1 INPP5D BIN1 TREML2 PTK2B APP EPHA1 FERMT2 PICALM APOE PMC6078181__F2 Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap CXCL10 APC CCL4 IL1B CFTR CCL3 PMC4254744__F6 HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes HMGB1 TLR4 MYD88 PMC2787631__F7 Working model of PKA’s role in trastuzumab resistance PDK2 EGFR PTEN PMC4760904__F6 Agrin and LRP4 are central to a chondrogenic signalling network LRP4 LRP5 LRP6 DKK1 ACAN COL2A1 SOX9 PMC5086377__F1 TNF signaling pathway anomalies through antiapoptotic signaling by TNFR1 helped by upregulation of TRAF1 and inhibition of proapoptotic TNFR1 signaling by BIRC1/3 caspase inactivation TRADD STAT4 LYN MYC IL2 CD40 TRAF2 FADD PMC6263441__F1 Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa SPO11 DMC1 SMC3 MSH6 MSH2 MSH4 RAD21 MSH5 REC8 PMC6452301__F4 Interplay of well-known germline and somatic mutations in atherogenesis SORT1 ANGPTL3 PCSK9 APC LPL APOA5 LDLR IL1B PMC8645963__F1 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer ME1 HEL-S-26 ME2 NADK ME3 PMC8645963__F2 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer ME1 HEL-S-26 ME2 NADK ME3 HEL-S-162eP PMC7500474__F1 11-Oxygenated C19 Steroids Do Not Distinguish the Hyperandrogenic Phenotype of PCOS Daughters from Girls with Obesity HSD11B2 SULT2A1 HSD3B2 CYP17A1 PMC5825090__F1 The folate pathway in pancreatic cancer risk CTH HEL-S-61p HEL-S-182mP MTR PC CHDH DHFR MTRR TYMS MTHFD1 PEMT PMC4972972__F1 Dual regulation of GSK3 by the PI3K/Akt/GSK3 pathway and PLIN2 APC ADFP LRP5 CCND1 LRP6 IRS1 PMC2757186__F9 Working model for the biochemical cascade leading to the AR PMC3032584__F1 NF-kappaB, a mediator for lung carcinogenesis and a target for lung cancer prevention and therapy TRADD LTB RELB TRAF2 PMC6628025__F1 Fibroblast growth factor receptors (FGFRs) are highly conserved transmembrane receptors consisting of three extracellular immunoglobulin-like (Ig-like) domains, a transmembrane helical region, and a cytoplasmic region with kinase activity FRS2 GRB2 PMC6707858__F1 Role of the Endolysosomal System in Parkinson’s disease VPS35 PINK1 LRRK2 VPS13C PMC6959064__F2 Calreticulin-mediated LMP1 signaling network that promotes EMT in NP69 cells CS KRT19 HEL-S-99n DES RIPK2 PLAT ANXA2 KRT5 SP1 TUBB NR3C1 AK4 RBM3 LMNA ITGB1 KRT18 HDAC1 SSBP1 HLA-B CFTR CASP3 CUL4B SIRT7 MAPK13 HEL-S-269 HEL113 PMC4005015__F9A DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES VHL HEL-S-133P PMC7521521__F1 Cullin-RING E3 ligases (CRLs) and the NEDD8 conjugation pathway SKP1 RBX1 DDB1 FBXW8 PMC6613878__F1 Therapeutic strategies targeting NAMPT against stroke NAPRT TSC2 SIRT2 NAMPT SIRT6 PARP1 MTOR SIRT1 NRK BAX PMC8699548__F2 Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities EGF EGFR IL6 IL6R STAT3 PMC7281185__F1 Impact of nitric oxide (NO) in senescence-mediated signaling pathways STAT1 COX2 CXCL1 ATM CCL5 CCL2 CXCL12 PMC6131595__F5 Metabolic reprogramming in cancer cells TIGAR PMC9587781__F3 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease NLRP3 UNG IL1B PMC3524013__F3 Full network comparison of the original canonical pathway and the inferred cell-type-specific pathway IL1A MAP3K1 IGF1 EGFR GRB2 MAP3K7 RAF1 TGFA TRAF2 IRS1 PMC9587781__F1 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease HEL-S-62p C5AR1 C9 C7 C6 PMC11099588__F1 Biological functions of Amot family proteins and associated signal transduction pathways RICTOR PATJ PDLIM2 ARHGAP17 AMOT YAP1 AMOTL2 AMOTL1 PALS1 MTOR NEDD4 PMC7851309__F8 Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice CCR6 CCR4 IL1R2 FOXP3 MAF NFATC2 GIG8 NR4A3 TGIF1 PTGDR2 GFI1 JAK1 RORA REL NFATC2IP PPARG IRF-1 SOCS1 PMC9587781__F2 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease C5AR1 CD59 IL16 TNF PMC6072627__F2 Intracellular activation of innate immune signaling by hyaluronan matrix TLR5 TLR4 CD44 ARHA MYD88 TIRAP PMC6566080__F9 Cytokine-cytokine receptor interaction signaling pathway map in the male group CCR5 CCR2 CCR3 CCR6 CCL21 IL1R2 CXCL3 TPO CCL5 IL11 IL17RB CCR1 CCR7 IL7R IL2 CXCL6 CD40LG IL4 IL1B IL1A IL13 LIF CXCL10 CCL4 IL6 TNF IL23R TSLP CNTF CXCR3 IL15 IL7 CXCR4 IL23A CCL20 CD40 CXCL12 OSM MPL IL17B CCL3 PMC8630747__F5 Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1B HIF1A STAT3 PMC7954711__F1 The B6 vitamers pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM) and the respective phosphate esters pyridoxal-5′-phosphate (PLP), pyridoxine-5′-phosphate (PNP) and pyridoxamine-5′-phosphate (PMP) PDX1 PC HEL-S-1a PNP PMC6566080__F8 Hematopoietic cell lineage signaling pathway in the male and female groups CD14 CDA ICE1 CD37 CD33 CD34 CD44 TPO CDS1 HEL-S-11 IL3 CD7 CD22 CD19 CD24 PMC8304501__F1 Oncolytic Virus-Induced Autophagy in Glioblastoma TSC2 TSC1 PTEN UVRAG MTOR RHEB PMC8745434__F1 Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time HHIP KIF7 DISP1 SUFU PTCH1 GLI3 CCNB1 ARHA SMO GAS1 RAC1 PMC129737__F5 Model for repair of camptothecin-induced replicative damage RAD1 TDP1 PMC4283622__F1 Capecitabine activation and subsequent 5-FU activation, action, transport and catabolism CDA DPYD CES2 RRM1 UCK2 RRM2 DPYS UPP2 TYMS UMPS TYMP TK1 PMC3548426__F1 Telomere syndromes CTC1 STN1 TEN1 NHP2 GAR1 TPP1 NOP10 TERT PMC5342330__F9 Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells NUMB IGF1R SOX2 NOTCH1 SRC LNX1 STAT3 PMC6855070__F2 Molecular pathway signaling of angiogenesis-induced epithelial-mesenchymal transition in hepatocellular carcinoma HGF VEGFA TGFB1 PMC3137145__F3 Cigarette smoke exposure induces autophagy and apoptosis EGR1 ATG12 ATG3 DKFZp686F0183 PMC2643977__F4 Proposed integrated model for local water transport inhibition by activation of P2Y2 and adenosine A1 receptors (A1R) in inner medullary collecting duct principal cell AQP3 AVP AQP2 AQP4 PMC11647666__F11 Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms FOSL1 EGFR APC MTOR CCN4 TRPM7 ROR1 RHEB SOX9 TSC2 TSC1 ROR2 BNIP3 PMC5650456__F1 Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma EGF KIT BRAF NGF EGFR NRAS BCL2 CD80 LAG3 TGFA CEACAM1 PMC2716541__F6 Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation GADD45B CDKN1B BCL2 GADD45A SESN1 PTEN TNFRSF10B CCND2 CITED2 PMC2881756__F7 Model illustrating the role of WDR3 in mediating cross-talk between ribosome biogenesis and p53-mediated cell cycle regulation WDR3 RPL11 MDM2 PMC3299554__F1 Diagrammatic representation of the Akt signaling pathway.Notes: Activation of receptor tyrosine kinase (RTK) by growth factor binding activates PIK3 BAD MDM2 CCND1 PTEN MTOR PMC4829553__F4 Genes positively and negatively connected to the expression of Egfr in the mouse liver FOXB1 E2F4 IKBKG RANBP1 TRAM1 TFG SI SLAMF9 EGFR SEC61B CSA2 PMC4059147__F5 Scheme for GAG biosynthesis (chondroitin/dermatan and heparan sulfate synthesis and keratan sulfate synthesis pathway) (A) and degradation (B) HS6ST1 GNS SGSH HEXA GALNS EXT2 EXTL2 CHST12 HYAL2 UST HYAL3 HYAL4 CHST14 HPSE GUSB HGSNAT CHST7 HEL-S-111 CHPF HPSE2 IDUA GLCE B3GALT6 PMC9610022__F3 High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models AMH MTOR PMC4548049__F2 Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3 TBK1 CGAS TRAF3 IRF3 TLR3 PMC9106715__F8 Working model displays the mechanism of which RP1-59D14.5-modulated PCa tumorigenesis and progression TEAD3 TEAD4 LATS1 LATS2 TEAD2 PMC5391049__F1 Wnt Signaling and Colorectal Cancer RNF43 APC GSK3B MYC PORCN GPR49 AXIN2 LGR6 TNKS2 WLS PMC4829553__F3 Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments? E2F4 IKBKG EGFR AK2 HEL-S-2a FOXB1 RANBP1 TRAM1 TFG SI SLAMF9 SEC61B FKBP11 CPB2 GDPD1 PTDSS1 GNAT2 SSR1 DGCR6 SLC37A3 FARP1 RNP24 SLC27A5 CSA2 SEC61G EHHADH PMC2538513__F2 The involvement of death receptor pathway (right half) and mitochondrial pathway mediated (left half) apoptosis in nurse cell formation TRADD APAF1 TNF TRAF2 FADD PMC2538513__F4 Schematic illustration of the involvement of c-Ski and TGFB signaling pathway in nurse cell formation SMAD2 SMAD4 SKI PMC3086210__F9 NH2-terminal Propeptide of Type I Procollagen Acts Intracellularly to Modulate Cell Function TGFBR1 SMAD4 PMC10532419__F3 LOXL2 in Cancer: A Two-Decade Perspective LOXL2 FOS ZEB2 EGFL7 KDM4C ZRANB1 SP1 TRIM44 PMC10532419__F4 LOXL2 in Cancer: A Two-Decade Perspective VEGFC LOXL2 PMC9229135__F2 Clinical Escherichia coli: From Biofilm Formation to New Antibiofilm Strategies FLI1 FIGN PMC8113272__F2 Genomic network analysis showing the central role of genes related with cell cycle pathway SALL4 NDN ZBTB7A SNAI1 PBRM1 F2R NPM1 CSNK2A1 CTBP1 TBX3 GSK3B MYC F2RL1 STX1A WT1 SOX9 THRA RXRB RARA RARB POMC TIMP3 ZEB2 ASXL1 MDM2 CCND1 TBX5 MAPK1 SMO CDK4 TFAP2A RUNX1 YBX1 PIR CD44 LRP6 IFNB1 RXRA IKBKB MCM3 TWIST1 ADAM10 ATR RPL5 CTNND2 CAMK2A CAMKK2 PMC6306679__F4 Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy NAMPT NMNAT2 NNT NMNAT3 PMC8192371__F1 Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer TLR4 EGFR CD40 HEL-S-92n LAG3 PMC5562708__F7 IRS4 interferes with BMP signal transduction and functions as a novel regulator of BMP signalling and myogenesis IRS4 GSK3B SMAD4 MTOR ID1 SMAD1 DKFZp781O1323 PMC5101720__F8 Pathway analysis using the KEGG Pathway database REN RPN2 ARC RP2 RPN1 PMC5101720__F7 Pathway analysis using the KEGG Pathway database REN RPN2 ARC RP2 RPE PMC3058357__F3 GRAIL and Otub1 regulation by the mTOR pathway controls naïve CD4 T cell proliferation IL2 MTOR PMC6895440__F2 Several typical post-translational modifications of PGK1 PIN1 HDAC3 EGFR MTOR PDPK1 HEL-S-68p PMC11464892__F7 IL-17 signaling pathway in CD 138 + MM cells TH MMP3 MMP9 APP USP25 TNF IL17RC FADD S100A7 TAB3 PMC6895440__F3 PGK1 involvement in drug resistance FOSL1 HIF1A DNMT3B HEL-S-68p PMC8913496__F1 RhoG’s Role in T Cell Activation and Function ARHG APC IL7R JAK3 JAK1 ORAI1 STIM1 STIM2 PMC6594866__F2 Key cytokines and transcription factors involved in the regulation of megakaryocyte maturation FLI1 NFE2 NOTCH4 IGF1 ETV6 TPO CCL5 IL1B MPL GATA2 GATA1 PMC8074291__F7 Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells IL16 EGFR BCL2 IL6 TNF MTOR STAT3 PMC3240668__F6 Fibronectin - c-Myc network RPL31 RPL12 BTK GDI2 OAS2 MNT RPS19 KHSRP E4F1 TINAG RPL23 ABCB10 PSMC4 NPC2 HNRNPF KLF6 RPS20 HEL70 HEL-S-28 APC VEGFA ENO1 SHE RPL4 RPL15 HRAS FUS MCM3 GRB2 FSHR PMC8533551__F1 Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis BMPR2 BMP2 ENG PMC7490524__F1 Alternative splicing rewires Hippo signaling during chronic liver injury and HCC SOX2 NF2 ESRP2 MBNL3 PMC3584681__F2 Pattern-recognition receptors (PRRs) and signaling pathways that lead to differentiation of antifungal T helper (Th) cells TH NLRP3 CARD9 BCL10 RELB UNK IRF3 MYD88 IL1B MAL PMC4488795__F2 Hepatic lipid homeostasis is regulated by LRP6 PCSK9 LDLR LRP6 ELOVL6 TG PMC3016145__F1 Intracellular and extracellular chromogranin/secretogranin actions SCG2 CHGB NPY PMC4783290__F7 Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development MCC PDC CS ETV4 PMC6732626__F7 In the DP-treated cells, DP preferentially recognized and activated EGFR receptors on the cell surface EGFR MTOR PMC5742578__F1 Structure and function of ARNAX IRF3 TLR3 MAVS TICAM1 PMC3472468__F4 Effects of sleep deprivation on the insulin signaling pathway SOCS2 PPP1R3G PPP1R1A PPP1R7 FOS EIF4E MTOR FOXO1 RHEB INSR EXOC7 TSC2 TSC1 PMC7331746__F3 Essential functions of mitochondrial dynamics in immune cells MFN2 CD163 CD40 IRF-1 IFNG PMC6296478__F1 Post-transcriptional regulation of cytokine expression and signaling RUNX3 SOCS3 RUNX1 TNFSF10 STK4 TRAF6 ECSIT MYD88 SP1 MAP3K7IP1 PMC7331746__F4 Essential functions of mitochondrial dynamics in immune cells CD14 MFN2 PDC BIK RIPK3 TNF MTOR PMC9319897__F5 Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers IL7 IL18 CXCL10 CRP CCL17 IL6 CCL2 IL1B GLA PMC7331746__F2 Essential functions of mitochondrial dynamics in immune cells MFN2 CD80 IRF-1 OPA1 PMC4741699__F1 Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors SMAD2 EGFR CD44 GSK3A SHE PTEN MTOR SMAD9 PAK1 MDM2 TYK2 SMAD1 DKFZp781O1323 PMC12138068__F2 Phosphorylation and collagen-related diseases STAT1 DDR1 TIMP1 FOXM1 PEBP4 SMAD2 APC LRP5 LRP6 IRF3 IL1B STAT3 PMC11944037__F11 Biomarker-pathway-target network diagram of IPE anti-RA MAPK8 PTGS2 MAPK10 ALB MAPK14 LCN2 TYMP ARHA HEL-S-49 DHFR SRC BST1 PNP PMC4301309__F1 Central role of NMPRTase (Nampt*) in the salvage pathway for NAD biosynthesis and related cellular functions NAMPT NMNAT1 NMNAT2 NMNAT3 PMC12138068__F4 Ubiquitination, SUMOylation, methylation and collagen-related diseases PRMT1 TRIM13 SMURF2 PRMT3 EGFR FGFR3 SENP2 EZH2 PMC8424979__F5 Tetraploidization event shaped the Aquilaria sinensis genome and contributed to the ability of sesquiterpenes synthesis MVD FDPS IPP HMGCR PMC8804219__F2 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products MAF ANGPTL4 FACL4 GCLC FTH1 RPA1 SLC7A11 HEL-S-64p GLS2 TFRC SLC40A1 EMP1 PMC7509998__F1 Pathway activation of Notch signalling receptors and their downstream signalling molecules JAG2 FURIN PMC9490047__F1 Current applications of adipose-derived mesenchymal stem cells in bone repair and regeneration: A review of cell experiments, animal models, and clinical trials RUNX2 LRP5 VHL LRP6 PMC2574011__F1 Store-operated Ca2+ entry in T cells LCK ORAI1 LAT FOXP3 PMC5797066__F3 Decorin and downstream signaling cascades in tumor cells TIMP3 EGFR MYC HEL164 VEGFA ARHA MTOR PEG3 PMC10968131__F5 EFNA4, FGFR4, SLC3A2, and HNF1A are involved in signaling pathways that may promote carcinogenesis PIK3CD BRAF APC HNF1A FGFR4 ERAS MTOR HRAS MDM2 GRB2 SLC3A2 RAF1 ARAF PMC8804219__F1 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 FTH1 SMAD2 FTL SMAD4 GLS2 VDAC3 IPP FBXL5 HEL60 NQO1 HMGCR STAT1 HEL-S-64p HEL-75 IREB2 SLC3A2 TGFB1 PMC6434238__F2 Network for abnormal sub-pathway IGF1R PPP3CA GSK3B SMAD4 PTEN RB1 FGFR2 CCND2 RARA JUP CCND1 RBL2 PPP1R1A FOXO3A CDKN1B FGF2 SEMA3B JRK CALML6 PIK3R5 GYS2 PPP1CC PPP3R1 RPS6KA1 SLC38A3 CDK2 YLPM1 PPP2R5C GRB2 MAP3K14 SOS1 CAMK2A PIK3R2 AKT3 PMC3275089__F1 Schematic overview of the ABeta-Cav1.2-ptau-autophagy pathway APP CALHM1 CAV2 PMC3936506__F3 Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response SSB CCND1 BAX PMC7578249__F4 Impaired monocytes function in ACLF CCR2 TLR4 IL33 CD80 MERTK PMC7098821__F1 Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease FGF21 PINK1 GDF15 PMC4169465__F1 The Role of Iron in Prion Disease and Other Neurodegenerative Diseases STEAP3 TF CP PMC9066069__F3 High‐fat diet (HFD)‐induced reprogramming of the hepatic clock and metabolic homeostasis NAMPT SIRT1 PMC7656422__F1 Immune suppression of Tregs via trans-endocytosis of CD80/86 from APCs CD80 PMC7037210__F1 Main anticancer molecular mechanisms mediated by cannabinoid receptors’ activation “↑, upregulation” and “↓, downregulation” BAD ATF4 SRC ARHA MTOR BAX PMC8227118__F7 Genome-Wide Differential Methylation Profiles from Two Terpene-Rich Medicinal Plant Extracts Administered in Osteoarthritis Rats BAD CD37 PTEN RAC1 MTOR RHEB TSC2 PI3 BCR MDM2 RAF1 PLEK ELF4 CD19 PMC10917649__SF6 Mapping of the identified gene classes of MetaCyc PWYG-321 mycolate biosynthesis to the KEGG ko00061 fatty acid biosynthesis pathway CBR4 HEXA FES MECR OXSM CP FASN HTD2 PMC8582545__F1 Disruption of Tumor Suppressors HNF4A/HNF1A Causes Tumorigenesis in Liver TRADD TRAF2 STAT3 PMC7350758__F1 Vital signaling pathways and important substrates for downstream regulation of USP4 NLK USP4 SMAD4 HDAC2 TRAF2 TCF4 PMC11817781__F4 Top 10 genes and associated critical phenotypes network TRPV4 PLAT SQSTM1 GDNF HMOX1 PMC12199322__S1 Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway HMGB1 STAT3 PMC5814137__F4 Heterocellular nutrient symbiosis in the tumor microenvironment.Tumor-associated stromal cell populations engage in cooperative metabolic processes with cancer cells in the tumor microenvironment MSC TEF CIT PMC5673281__F3 Bile acids as global regulators of hepatic nutrient metabolism EGFR SRC SPHK2 PMC2118421__F7 Proposed model of RasGRP1 in FcɛRI-mediated signaling FYN LYN GRB2 ARHA SYK PMC5668920__F1 Fas apoptotic pathway NRAS LRBA PMC7327349__F1 Graph of the IL-17 signaling pathway in KEGG database MMP3 PLG MMP9 LCN2 MPL FADD ELL PMC3004266__F10 Active Cdk1/cyclin B1 complex on the extrinsic death pathway CCNB1 CDC2 FADD PMC10546379__F7 SIK2 on Wnt/Beta-catenin signaling pathway HEL-S-26 PHLPP2 SIK2 LRP6 PMC6609682__F7 IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGFB signaling pathway IFITM3 SMAD2 SMAD4 PMC10217969__F5 Transcriptome and Metabolome Reveal Distinct Sugar Accumulation Pattern between PCNA and PCA Mature Persimmon Fruit TREH GYG1 PMC11083682__F3 Influenza viral degradation of cellular proteins that do not directly regulate IFN signaling PML IFITM3 NLRX1 HDAC11 SSU72 GPS2 MOV10 CCND3 HDAC1 FBXO6 CFTR STAT1 CHD6 MDM2 HEL-S-44 HDAC2 EIF4B ITCH PMC10546379__F4 SIK1 inhibits tumor cell EMT by suppressing Beta-catenin signaling pathway and the expression of Twist 1 LEF1 SIK1 TCF4 PMC11083682__F2 Influenza viral degradation of cellular proteins involved in the interferon responses IRF9 TRAF6 PARP1 IFNGR2 IRF3 IFNAR2 IFNAR1 DNMT3B NBR1 IFNLR1 STAT1 FBXO45 RNF5 TYK2 JAK1 IFNGR1 MAVS SOCS1 PMC2820418__F12 PRG5 signaling in axon growth and neurite retraction ARHA LPA CDC42 PMC7723774__F1 Preparation of the chitosan/sodium alginate (CA/SA) hydrogel simultaneously loaded with parathyroid hormone fragment PTH(1–34) and nano-hydroxyapatite for promoting cranial bone regeneration via the Notch signaling pathway HES5 RUNX2 BMP2 PTH HES1 PMC12249179__F8 Correction: Ye et al. The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer. Cancers 2022, 14, 2101 PMC8358831__F3 Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer AREG LIF SCRIB LATS1 LATS2 PMC6120108__F2 The BDNF/ TrkB signalling in normal and glaucomatous conditions PLCG1 ATF4 EIF2A GRB2 BDNF PMC8495202__F2 Desmosomes as Signaling Hubs in the Regulation of Cell Behavior EGF PKP2 PKP1 DSG1 DSG2 PKP3 EGFR DSG3 DSG4 DSC1 PMC6120108__F3 Downstream consequences of neurotrophin signalling pathway affecting gene function and ER stress marker is possibly implicated in progression of RGCs axon damage in glaucoma UBC ATF4 EIF2A WDR36 MYOC OPTN ATF6B XBP1 TMCO1 PMC4716813__F2 Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? ACE2 PMC8980962__F5 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? EPO JAK3 IL2RB STAT3 PMC8980962__F2 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? STAT2 STAT4 TYK2 JAK1 IL23R STAT3 PMC11591759__F1 Two possible options for the interaction of Notch signaling pathway targets (Hes1, Hey1) with Runx2 RUNX2 HES1 PMC1847591__F1 Drugs that regulate hepatic bile acid and other organic solute uptake, synthesis, detoxification and secretion CYP3A4 SULT2A1 CYP7A1 PMC10244093__F9 Linc00662 m6A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway ITGA1 IGF2BP3 SRC GTF2B PMC6849407__F8 Schematic diagram of the potential mechanisms for CDDO-Me–mediated Nrf2 activation in CHF AREL1 COX2 KEAP1 GCLC NQO1 PMC8678517__F2 Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer BMP10 SMAD2 TGFBR2 SMAD4 SMAD1 DKFZp781O1323 ACTR2 SMAD9 PMC10970410__F8 Transcriptional Regulatory Networks (TRNs) based on DE pcRNAs common to KLF4KD and MXD4KD cells, in association with lncRNAs CYP4F11 BAMBI CENPH GSTA4 RPA3 ID4 SPC24 CDKN3 CTGF CACNA1A CDH2 PRR9 HAS2 PTX3 PLCB4 EDN1 HEL113 RORA BDNF TPM1 CX3CL1 GUCY1A2 TLN2 GBP2 CCND1 GDNF JUN PTTG1 FGF7 ITGA1 HEL-S-75 WWC1 XYLT1 RGS4 PITX2 BMPER HAUS4 PPP2R5A H2BC12 CA9 MMP16 IL6 TLR1 SCN8A LCP1 PRKD1 SPRR4 FAT4 TAGLN ADAMTS14 HS3ST3A1 SELPLG HEL-S-10 MGST1 KALRN SCUBE3 NR4A3 OXTR CCNB2 NEK2 APOL6 CEP70 PLA2G4C ATOH8 CHSY3 CD226 ST3GAL1 WNT5B GBP4 JAM2 NTNG1 FZD8 PMC4731439__F1 TNFAlpha-related signal transduction pathway participating in the differentiation of skin appendages EDARADD EDAR CYLD TRAF3 TRAF6 FURIN PMC7591509__F4 Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis LTA ALOX15 ALOX12 LTB PTGES ALOX5 PMC4731439__F2 Interaction of proteins involved in signal transduction via the TNFAlpha-related signal transduction pathway (based on http://string-db.org, simplified) UBC CYLD TRAF6 FURIN MAP3K7IP1 TNLG7C PMC8146983__SF1 Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes AASDH AADAT AASS GCDH PMC11683013__F2 CGAS-STING pathway activation, Chinese medicine inhibits or activates cGAS-STING signaling pathway to treat various diseases TBK1 CGAS IRF3 IL6 PMC2971525__F1 DNA Damage Response (DDR) pathways in normal and malignant cells CDK2 ATR H2AX FOXO1 BAX PMC8835786__F3 SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19 TBK1 TRAF3 IRF3 PMC3823115__F3 Potential mechanism of the HGF/ c-Met signal pathway hallmarks in lung cancer HGF EGFR MTOR PMC3823115__F1 TGFa/EGFR signal pathway may directly or indirectly lead to c-Met, while HGF/c-Met does not affect the phosphorylation of EGFR ANXA1 HGF EGFR TGFA PMC6923165__F3 Time-dependent changes of gene expression of the KRAS signaling pathway after treatment of PDAC model cell lines differing by the KRAS mutation status with paclitaxel in vitro BRAF RIN1 GSK3B RALA MAP2K2 ARHA PTEN RAC1 RALBP1 MTOR PDPK1 PRKCA PI3 PAK1 MAP2K1 PTK2B PIK3CA RAF1 ARAF PMC7913947__F1 The kynurenine pathway HEL-S-90n KMO PMC6328617__F1 CD44v6 engages in colorectal cancer progression MMP2 MMP9 CD44 SRC PMC3136091__F1 Canonical and non-canonical NFKB signalling pathways RELA RELB PMC6328617__F2 CD44v6 engages in colorectal cancer progression MMP2 CD44 CCL5 CXCL12 HRAS PMC5521196__F5 Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function LEF1 SOX17 PMC3200485__F2 RGS14 at the interface of hippocampal signaling and synaptic plasticity EGF HEL-S-11 CA3 HRAS RIC8A PSD RGS14 PMC6308626__F2 General mechanism of the extracellular signal-regulated kinase (ERK) pathway and key downstream products important in cocaine addiction FOS CDK5 JUN PMC8584463__F7 Substrate Stiffness Drives Epithelial to Mesenchymal Transition and Proliferation through the NEAT1-Wnt/Beta-Catenin Pathway in Liver Cancer RUNX2 APC CD44 VEGFA AXIN2 TF PMC4791550__F2 Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans SOCS3 CISH CXCR5 SOCS1 STAT3 BATF PMC2094118__F1 The HIF1 pathway in normoxia (A) and hypoxia (B) ING4 VHL HIF1A PMC4811429__F6 Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes DKFZp686L0365 HHIP SUFU GSK3B SHH ADRBK1 PMC1572165__F3 Schematic drawing that shows the importance of cell-to-cell and cell-to-matrix-interactions in endothelial cell survival BAD IFNG BAX PMC6404322__F1 Challenges of driving CD30-directed CAR-T cells to the clinic CCR4 CCL17 CCL22 PMC11591759__F2 Tissue-specific effect of the Runx2 transcription factor and its associations with various signaling pathways and target genes MPZ RUNX2 MBP DKK1 IL2RB PMC11663918__F1 Changes in proteins induced in the cytosol of microglia activated by BzATP and lipopolysaccharide (LPS) NLRP3 EGR1 TRAF6 MYD88 TNF TNFAIP3 PMC8465379__F4 An Updated Comprehensive Review on Vitamin A and Carotenoids in Breast Cancer: Mechanisms, Genetics, Assessment, Current Evidence, and Future Clinical Implications EGFR MTOR BAX PMC7002996__F5 KEGG pathway analysis of the p53 signaling pathway regulated by PCA MYC PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 AIFM2 PERP ATM MDM2 CDK4 ATR BAX PMC4038464__F3 Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease PCK1 ACACA GCK HEL-S-32 HEL-S-5 MDH2 PC HEL-S-278 SLC2A2 SLC2A3 MPC1 MPC2 DECR2 MDH1B PCK2 PDHX PGAM1 HEL-S-133P HK2 PGAM2 HEL-S-281 FASN GPD1 ALDOB ENO3 FBP2 FBP1 ENO1 HEL-S-87p HEL-S-162eP HEL-S-68p HEL-S-49 SLC2A4 ENO2 PMC10454035__F2 Hedgehog (Hh) signaling pathway, normal and with Gorlin syndrome PTCH2 SUFU PTCH1 GLI3 SMO PMC7226803__F3 Subcellular distribution of FoxO1 driven by nutritive stimuli in white/beige adipocytes IGF1 INS INSR PMC3423785__F2 Functional analysis of the top-scoring network of AE9a dysregulated genes MEIS1 ALOX5 LGALS7B CCNB1 APP LPP KLF6 SORT1 GM2A NAB1 NAB2 HBD Nbla10317 AIF1 DACH1 PSAP CEP55 GADD45A NUP210 CYBB SPTB KLF3 KLF7 RNF144B CDKN1A HSPA1A PRKCH PMC7397661__F3 Interrelated regulatory of CircRNA and EMT HMGA2 CDH2 PMC2862093__F6 Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway PI3 PDK2 IRS1 GLP1R PMC4552880__F1 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis ITGB6 ITGA2 COL2A1 LAMC2 RELN CD47 COL27A1 CD44 LAMB2 THBS4 LAMA3 LAMA1 TNC ITGB4 HMMR HSPG2 THBS2 THBS3 VTN IBSP CHAD TNR ITGAV COL24A1 COMP GP1BB GP1BA GP6 CD36 AGRN PMC6328617__F3 CD44v6 engages in colorectal cancer progression EGF HGF CXCR4 EGFR CD44 CXCL12 PMC6328617__F4 CD44v6 engages in colorectal cancer progression KEAP1 FTH1 MDM2 CD44 HMOX1 NQO1 PMC4552880__F2 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis BAMBI NODAL SMAD2 SMAD4 SKP1 ARHA RBX1 IFNG FST C6 THBS1 SP1 SMAD1 PMC3606754__F2 STRING analysis of the relationship between genes BTNL2 TH RETN HLA-G MMP11 ABO VEGFA TPH2 HLA-B MMP3 LTA PC KDR HP CRP MSH6 MICA PMC3606754__F3 NF-AT signaling and leukocyte interactions have been enriched by GeneGo ITK CCR3 IL13RA1 BCR HEL-S-11 LCK ZAP70 CD40 IL4 LAT PMC8165262__F1 Interleukin-27 and Its Diverse Effects on Bacterial Infections EBI3 TYK2 JAK1 PMC3924248__F1 Contribution of MTHFR, MTR and MTHFD1 in the folate metabolic pathway MTR VIT MTHFD1 PMC4315992__F8 Signaling pathways for PDGF-induced proliferation in PSCs STAT1 SRC STAT3 PMC3192752__F5 Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment CYP8B1 BAAT CYP7A1 PMC11450209__F3 Exploring kinase-substrate interactions of proteins using KiNet BAD BRAF MAPK8 ROCK1 TTK EGFR PAK6 MAPK3 TGFBR1 MYC KLF10 MAPK14 PRKAA1 EEF1A1 EEF1A2 LATS1 INSR PTPN1 KSR1 SRC MAPK1 SGK1 ROCK2 MAP3K7 MAP2K2 IRS1 PINK1 PAK1 MAP2K1 RPS6KA1 RAF1 AKT3 PMC3944239__F8 Working model WEE1 ORC1L ARHA CDT1 PMC7180799__F6 Proposed signaling pathways for the protective effect of LPA against simvastatin-induced cytotoxicity in L6 cells BAD BCL2 LPA MTOR PMC9691847__F6 Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NFKB-mediated inflammatory response TLR4 MYD88 TNF IL1B PMC3337844__F1 Autophagic proteins FADD PMC8820459__F1 p38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects MAX ATF2 PMC9458461__F6 Nuclear DNA damage response by mitochondrial morphofunctional pathway MFN1 MFN2 ATM BRCA1 PMC7791134__F3 Distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells BIRC5 TACR1 ZCCHC12 ERCC6L CDCA2 COL1A1 RAMP3 CHRM5 KIF11 PDE11A GNG4 NUF2 ECT2 PRND RRM2 KNTC2 ECEL1 CCNB1 ADAM33 TACR3 ESCO2 TRHR CDC2 TMIE FNDC1 TMEM215 SPC25 CEP55 AURKB UBE2C HMMR BUB1B TRH HEL164 AVP PMC6137129__F8 Visualization of KEGG IL17 signaling pathway genes differentially perturbed (FDR < 0.05) in rat muscle infected with A TH GNE LIF LCN2 TRAF6 TRAF2 FADD BOLL ELL TAB3 PMC6122050__F1 Tyrosine metabolic pathway – highlighting the site of the enzyme defect observed in alkaptonuria and type 1 hereditary tyrosinaemia and the site of action of nitisinone PNMT DBH TRH PMC6090502__F9 Model for NG2 ICD-mediated intracellular signaling in OPCs EEF2K PC EEF2 MTOR EIF4B PMC11079285__F3 TREM2 mediated immunosuppression and regulation of cancer progression GSK3B PMC6587274__F5 Summary of STAT3-FOXL2 signaling function in HeLa cell growth and apoptosis GNRHR TNF FOXL2 STAT3 PMC7792759__F3 TGFB signalling pathway in breast cancer cells HOXB7 SMAD2 SMAD4 PMC5043614__F1 Molecular subclassification of triple-negative breast cancer (TNBC) based on gene expression profiling GRB2 SRC PTEN MTOR BRCA1 CDC42 PMC5043614__F2 Links between altered glucose and phosphatidylcholine metabolism in breast cancer EGFR LPL MTOR PMC11450209__F4 Exploring kinase-substrate interactions in functional contexts, such as pathways and shared domains using KiNet TH TPH1 HIPK2 HDAC3 SIK2 CSNK2A1 EGFR MAPK3 GSK3B TPH2 PRKAA1 PAK4 HDAC5 PAH PTS CAMK4 MAPKAPK5 SRC HDAC2 MAPK1 MAPKAPK2 CAMK2D LRRK2 PRKAA2 HDAC8 HDAC7 RPS6KA5 MAP3K7 CDK5 CAMK2G PRKG1 PRKD3 PRKD2 CAMK1 HDAC1 PKN1 PRKD1 AURKB SPR DHFR CAMK2A PMC5670149__F1 Wnt/Beta-Catenin Signaling HEL-S-28 SMAD2 APC LRP5 SMAD4 LRP6 PMC11079285__F2 TREM2, as an oncogene, promotes the progression of PTC, GC, PRAD, RCC, EAC, and BCC by activating the PI3K/Akt, NFKB, and JAK/STAT3 signaling pathways, respectively GC SYK STAT3 PMC4516462__F2 Transcriptional modifications of DNA repair by UPS in response to cellular stressing conditions POLE BARD1 LIG1 BRCA1 MPG PMC1896004__F4 Signaling pathways downstream of the Toll/TLRs TRAF6 ECSIT MYD88 PMC4516462__F3 Transcriptional activation of DNA repair mediated by UPS-dependent pathways PML MDM2 XPC RAD51 DDB2 MSH2 BRCA1 PCNA MPG PMS2 PMC9297598__F11 Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages MSC CCL4 TNF ARG1 KLF6 STAT3 PMC6374299__F2 MDSC-dependent promotion of PMN formation and evolution HMGB1 TLR4 CXCR4 MMP9 S100A8 CXCL12 ARG1 PMC8395144__F1 An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches GCLM KEAP1 GCLC NQO1 PMC9273597__F1 STING cg16983159 methylation: a key factor for glioblastoma immunosuppression CGAS CXCL10 IRF3 PMC7961553__F8 AIM2 function in microglia as a negative regulator of EAE CGAS IRF3 AIM2 AKT3 PMC7374198__F4 General overview of the lipid metabolism in Malassezia, based on lipidomic and in silico genomic analysis presented in and PC FAT1 PMC4756744__F1 AVP-dependent signaling pathways in myogenic cells AVP GATA4 PMC9280743__F7 Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments TM6SF2 CPT1A FASN PMC7244374__F1 Vitamin A uptake, transport, and metabolism LRAT HEL111 SCARB1 RBP4 PMC3590201__F2 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations FST NODAL PITX2 SMAD6 SMAD4 SKP1 ARHA LTBP1 IFNG PMC3590201__F3 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations BCR MCU CAV2 PMC3523093__F1 Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches EGF BAD ATF2 JUND JUNB TNF IRS1 BAX PMC9271392__F5 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk CS MYF5 APC LRP5 LRP6 PMC9271392__F6 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk CS MYF5 SMAD2 APC PMC9271392__F3 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk CS APC LRP5 LRP6 PMC6723230__F2 Representative miRNA-gene network interactions between the genes with an altered expression levels when comparing tumor to normal tissue and their respective miRNAs, generated using miRNet HHIP PTCH2 SDC1 SFN BMP2 CD44 GAS1 DDB2 IL6 SDC3 CCND2 IGF1 PERP CDKN1A SDC4 SCD WNT4 RRM2 BBC3 GLI3 PMAIP1 CCND1 BCL2 AGRN PMC12238274__F3 Possible mechanisms of ApoE4 in microglial immune activation NLRP3 HMGB1 TLR4 LILRB3 NOX4 MYD88 TNF MTOR TRAF2 CD36 GLS PMC4558214__F1 Soluble recombinant molecule consisting of the extracellular domains of CD80 linked to the Fc domain of Ig (soluble CD80 or CD80-Fc) has the potential to maintain and facilitate T cell activation through three independent mechanisms APC CD80 CTLA4 PMC4628649__F2 Proposed model of the role of TOX in innate lymphoid cell development GIG8 IL7R NFIL3 TOX TF PMC12238274__F1 Possible mechanisms by which ApoE4 affects AB production and clearance BACE1 CDK5 APP MTOR PMC11896656__F1 Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling TBK1 CGAS STAT2 IRF7 IFNGR2 IRF3 IFNAR2 MTOR IFNAR1 TLR3 STAT1 TYK2 JAK1 IFNGR1 IFI16 PMC12238274__F2 Possible mechanisms by which ApoE4 affects tau phosphorylation and clearance CDK5 PPP2R5E TF PMC3382204__F5 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease IL21R IL3RA CCR3 HGF CCR6 CSF3 FLT4 CSF3R TPO IL2 LEPR CSF2 KIT BMP2 LIF CCR4 LTB IL24 IL6 TNF TNLG7C TSLP EDAR LEP LTA IL-21 CCL23 TGFA VEGFB OSM MPL INHBB LTBR INHBA INHBE PMC3073781__F6 Schematic overview of the MDM2 and p53 signalling pathway MYC MDM2 BAX PMC3382204__F6 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease EPOR CD14 CD9 CD37 EPO CD33 CD34 CD44 TPO TNF IL3 CD2 CD7 CD22 IL2 CD40 CD19 CD36 CD24 PMC3382204__F7 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease HEL-S-62p F10 PROS1 F2R PLAUR TFPI CS PLG THBD F8 F9 PROC CPB2 CD59 PLAT C9 A2M F2 F5 F3 VWF C6 CR2 PMC7988715__F2 EZH2 overexpression in prostate cancer ERG MYC EZH2 TMPRSS2 PMC5644641__F1 Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway EGF EGFR GRB2 PMC11509156__F3 Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds GC PMC11749514__F5 Role of the key gene set in the signaling pathway in PI3K-AKT BAD CD37 IRF9 GFAP PTEN RAC1 MTOR IRS1 RHEB BCR MDM2 SYK RBL2 CD19 PMC4381970__F3 Biological activities of TACI TLR4 MYD88 ICOS BCL6 PMC3763651__F1 Schematic presentation depicting the regulation of receptor signaling through G-proteins SRC ARHA STAT3 PMC4744895__F1 Schematic diagram of potential mild freezing shock signaling pathways in barley PC CBL PMC6523340__F4 Simplified biosynthetic pathway of lignin and flavonols CAD ACD PMC3729625__F2 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling TSC2 ULK1 TSC1 ATG12 ATG3 ATG10 DKFZp686F0183 RHEB PMC3729625__F3 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling TIGAR ATG12 HEL-S-162eP PMC4577901__F3 Signaling network of genes that are strongly upregulated following MARV challenge of NHPs FOS CREB1 IRF3 NFKBIZ CXCL2 SAA1 JUN FOXL2 CEBPB PMC3729625__F5 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling HEL-S-44 PMC3444692__F2 ATF-2 is a nuclear target of p38/Jun N-terminal protein kinase (JNK) ATM ATF2 SMAD4 SMAD1 IL1B PMC4887869__F4 Hydrogen sulfide metabolite trimethylsulfonium is found in human urine HEL-S-64p RHD PMC5349796__F7 E2 and CTNNB1 signals in the oviductal ciliated and secretory epithelial cells regulating embryo transport NR3A2 KIF9 FOXJ1 PMC7330432__F10 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway RRM2 PCNA PMC1894978__F5 The secretory pathway under different ER stress conditions (t-PA secretion, tunicamycin and DTT) together with examples of genes that are transcriptionally induced or repressed RFT1 USO1 ALG2 HEL103 ALG3 MNS1 GAS1 SEC63 DPM2 SELL PMC7426153__F5 Microbial Strategies for Survival in the Glass Sponge Vazella pourtalesii ASPH FAP FES GIP CIT ACD PMC3823597__F7 Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes HSPG2 ANXA2 TNF MPL FSTL3 PMC8931781__F1 Biological Activity of 3-O-Acetyl-11-keto-Beta-Boswellic Acid in Nervous System Diseases TLR4 KEAP1 GADD45A IL1B PMC5981095__F3 General schematic diagram of molecular events that regulate proliferation, differentiation and the initiation of migration in the SVZ FYN SOX2 CDK5 SOX1 CDC42 EPHA4 HES1 PMC5981095__F5 General schematic of terminal translocation and differentiation in the CP during development CRK VLDLR SATB1 SRC FOXG1 TBR1 ROBO1 CUX2 DAB1 CDH2 RAPGEF2 NECTIN3 CP NECTIN1 EPHA4 PMC11770092__F9 Hypothetical model RELB RBM4 PMC8100301__F6 Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19 FABP2 CASP3 EDNRA BAD PTGS2 PMC5534294__F5 Signaling pathways underlying podocyte injury in DN GPR78 ROCK1 RHO PMC9229059__F1 Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach VASP BAD PRKCE PPP3CA ROCK1 PDE3A INS ATP1B4 CACNA1C INSR SLC8A2 KNG1 OPRD1 NPPA NPR2 ADRB1 ADCY1 MRM1 NPPB CD44 GNA13 NPPC ARHA RGS2 PDE2A ATP2B1 IRS1 CREB3 GATA4 PPIF PLCB1 CALML6 MYH6 PLN GNA11 MAP2K1 TRPC6 RAF1 MYLK4 AKT3 PMC7017417__F1 Scheme summarizing transient receptor potential canonical (TRPC) channel isoforms dysregulated under myocardial infarction (MI) and ischemia and reperfusion TRPC7 TRPC4 TRPC1 TRPC6 TRPC3 PMC5685775__F2 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis SMAD2 APC LRP5 SMAD4 LRP6 DKFZp781O1323 PMC7211126__F1 Schematic depiction of PD-related genes associated with different autophagy pathways VPS35 SNCA PINK1 LRRK2 HEL-S-67p PARK2 FBXO7 VPS13C PMC5685775__F4 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis GSK3B PTEN PMC4926487__F3 Schematic representation of the DNA repair system for neuroprotection implying that genome stability is sustained on several tumor suppressors ATM PTEN BRCA1 PMC12189591__F2 Biosynthesis pathway of SFA and MUFA with graph data of fatty acid composition in the plasma of the control and atherosclerosis (AS) group FADS2 ELOVL1 ELOVL5 FADS1 ELOVL6 PMC5290251__F1 Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) pro‐inflammatory signalling pathway NLRP3 NOD1 HEL-S-276 CARD8 ERBIN CAD TRIM27 TNFAIP3 NOD2 TAB3 PMC5723018__F9 FKBP11 affects the formation and progression of AAD VCAM1 MMP9 IL1B FKBP11 PMC12215251__F1 Wnt/Ca2+ signaling pathway, created in BioRender NLK ORAI1 STIM1 CDC42 PMC3342110__F1 Signaling pathways important for C INS PMC3493873__F1 TP53 mutation status-specific network of potential candidate driver genes shown based on their known and predicted functional interactions IGF1R CCNA2 BTRC PLK1 MAP2K4 EGFR HIF1A CCNE1 RARA ERBB4 CCNB1 CCND1 PTTG1 ADCY1 ERBB3 VEGFA CHEK1 IRS1 UBE2C GLI3 BCL2 GTSE1 CA12 SOCS1 ARNT2 ADCY9 PMC6660170__F1 Nanoparticle-mediated autophagy ATG12 MTOR DKFZp686F0183 PMC3565579__F1 Proposed mechanism for opioid modulation for TLR TBK1 TLR4 LBP IRF3 TLR1 TLR3 TIRAP PMC6262497__F4 JAK-STAT signaling pathway after treatment with N4-Eru LCK GRB2 SYK IL2RA JAK3 RAF1 PMC6262497__F3 Notch signaling pathway after treatment with N4-Eru HES5 NUMB HES1 PMC3955168__F3 The unfolded protein response (UPR) pathway and its chemical modulators ATF4 EIF2A XBP1 PMC7002394__F10 Insulin signaling cascade targeted by WEE in PA treated HepG2 cells DHRS9 RBP1 PDK4 IRS1 PMC6258353__F3 Proposed biosynthetic pathway for TNL A (1) supported by the isolation of congeners or shunt metabolites 4–11, as indicated by the dashed arrows TNIP2 TNIP3 IPP PMC7306689__F7 Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3 FGFR1 UBE2D3 CBL PMC7864817__F1 Metabolic changes induced by DOXO in cardiomyocytes ULK1 BCL2 MTOR IRS1 PMC11769378__F3 Activation of TLR2 signaling pathway by bacterial lipoproteins (BLPs) TRAF6 MYD88 TNF TIRAP PMC6124166__F1 Schematic model demonstrating how PTH signaling leads to changes in SOST and RANKL expression in osteocytes TH SIK2 SOST PTH CRTC2 HDAC5 MEF2C PMC9386877__F1 Taste transduction and channel synapses in taste buds OTOP1 CALHM3 CALHM1 TRPM5 PMC9523695__F6 Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway ATM MTOR PMC6643215__F9 Schematic diagram summarizing the anti-NSCLC action of butein via activation of ER stress and ROS generation ATF4 EIF2A BCL2 XBP1 BAX PMC10474147__F14 Mechanism underlying oxeiptosis KEAP1 AIFM1 PGAM5 PMC7600656__F5 Hepcidin expression via bone morphogenic protein (BMP)-SMAD signaling pathway in hepatocytes SMAD4 TMPRSS6 HFE TFRC SMAD1 DKFZp781O1323 TFR2 PMC3418550__F1 Pathways of SMX metabolism, bio-activation and detoxification, and pathway of GSH biosynthesis MPO HEL-S-64p NAT1 NAT2 PMC6721670__F5 Canonical pathways linked to hNgb binders in a non-stress condition TEC RHO ELF4 PMC6721670__F6 Upstream regulators and signaling cascades linked to the hNgb protein interactors in a non-stress condition MYB HEL-S-89n PRKCE FGF2 EGFR ACHE CDKN2A NME3 ID1 SHC3 EWSR1 NGB APP REST HEL113 HEL-117 HEL-S-93 PMC3589124__F7 FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage HIPK2 ATM FOXO3A BAX PMC4821380__F1 EGFR and IGF1R signaling pathways.Notes: Binding of extracellular ligands results in autophosphorylation of key tyrosine residues in the C-terminal domain of EGFR, which allows downstream proteins to bind through their Src homology 2 (SH2) domains TSC2 TSC1 IGF1R EGFR GRB2 PTEN MTOR IRS1 PMC4859809__F1 MicroRNA biogenesis pathways in cancer AGO1 AGO2 DGCR8 DICER1 AGO4 DROSHA XPO5 PMC4859809__F2 MicroRNA biogenesis pathways in cancer IL1A DGCR8 DICER1 ATF4 ATF2 DROSHA ATF1 ATF3 PMC11825590__F4 Portion of the canonical NFKB signaling pathway containing IRAK1 and inflammatory cytokines discussed in this study (IL-1beta, IL-6, and IL-8) IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 PMC5817867__F2 RTK-regulated signaling in breast cancer progression SOX2 NODAL ERBB2 TWIST1 EGFR MYC STARD13 PMC8623831__F4 Treatment of HT29 Human Colorectal Cancer Cell Line with Nanocarrier-Encapsulated Camptothecin Reveals Histone Modifier Genes in the Wnt Signaling Pathway as Important Molecular Cues for Colon Cancer Targeting ROCK1 SMAD4 CITED2 FEN1 USP34 MMP7 AFF4 MYO6 RPS27A RPL21 SCAF11 USP9X CCND1 KITLG SFRP1 DKC1 CDK4 ZFYVE16 FKBP4 TNRC6B SDC1 YBX1 APC MAP3K7 MCM3 TMEM97 SETD2 PMC7072884__F1 Schematic display of G-protein-coupled receptors (GPCRs) signalling in cognitive impairment BIK CASP9 BLK PMC3509892__F1 Transcriptional Changes Associated with Lack of Lipid Synthesis in Parasitoids CS PC SCD DLAT PMC6745947__F1 Hepcidin regulation by iron and erythropoiesis ERFE BMP6 EPO BMP2 TMPRSS6 HFE SMAD1 TF TFR2 PMC10903154__F4 Hippo pathway dysregulation from pancreas precursor lesions to malignancy ADM PAF1 SOX9 STAT3 PMC7811960__F2 Azithromycin effects in the pathophysiology of COVID-19 after receptor-mediated endocytosis, both viral (PAMP) and host released (DAMP) molecules trigger antiviral pathways IL10 CXCL10 APC IL2 IL6 IL4 ACE2 IL1B TF IFNG POLI PMC10903154__F1 Hippo signaling pathway and its network RUNX2 NF2 AREG MYC LATS1 MOB1A MOBKL1A LATS2 PMC9371685__F4 Sulfur and methane oxidation by a single microorganism NHS CYC1 RHO ACD PMC3746082__F3 Diabetes mellitus induced regulation of osteoclast CCR2 GC SRC TRAF6 SYK TNF MTOR IL6R PMC3779868__F1 Phosphoinositide signaling and its regulation by phosphatases ITK PI3 PTEN INPP4B INPP4A PMC3746082__F1 Diabetes mellitus induced regulation of osteoblast TWSG1 MGP RUNX2 SOST GRB2 PTH TNF HTR2B PMC3746082__F4 Diabetes mellitus induced regulation of skeletal muscle IGF1 GC EIF2A RAC1 TNF MTOR CDC42 PMC4902960__F6 Activation of NFKB and STATs signaling pathway in ZIKV-infected hNPCs TLR9 STAT2 IRF9 TRAF3 TRAF6 IRF3 MYD88 TLR3 STAT1 TLR8 TLR7 CXCR4 STAT4 CD40 CXCL12 TRAF2 STAT3 PMC8863963__F14 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer CD14 STX7 TLR4 MPO MARCO TUBB VAMP3 PIKFYVE HEL-S-99n RILP CD36 PMC3549317__F1 Lipid synthesis in yeast PC HEL-S-5 PMC8863963__F11 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer VASP BAD CD37 MEI1 HEL-S-28 SHE PTEN RHO RAC1 CRK RXRA FYN BCR GRB2 CYC1 SYK TOX RBL2 BOLL CD19 PMC4080186__F1 Rho GTPase signaling pathway represents a convergent approach to targeting fibrosis RHO LPA PMC6981023__F6 Graphic summary of the regulation of memory T cell response by mTOR and Stat3 SOCS3 HIF1A BCL6 STAT3 PMC5795459__F1 Canonical type I and III IFN signaling STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 IL10RB PMC9572342__F9 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA RPRM APAF1 TP73 PTEN BAX PMC7313026__F2 RNF186, RNF182, and RNF152 are involved in the regulation of the mTORC1 pathway USP4 EGF RNF182 RNF186 EGFR RNF152 SHH RHEB FOXA2 PMC8647434__F1 Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer PDGFD VEGFC VEGFA PROX1 HIF1A PMC8486873__F2 ER stress regulate the secretion of EVs which contained immunomodulatory factors IL10 HMGB1 TLR4 APC PTEN PMC8486873__F3 DNA damage stress induced the release of immunomodulatory cargoes through EVs CGAS IRF3 IL1B PMC3970768__F1 The biotin cycle and the known and putative roles MCC PC PMC7974027__F7 Schematic depicting possiblem echanisms governing the pro-tumorigenesis effect of NET and miR181a targets in the PGRMC1/EGFR–PI3K/Akt/mTOR signaling pathway in breastepithelialMCF10Acells EGFR CASP9 CCND1 BCL2 PTEN MTOR PGRMC1 PCNA PMC2728746__F7 Proposed model for the mitogen-activated protein kinase kinase 4 (MEK4) regulation of human prostate cell motility and for its inhibition by genistein MAPKAPK2 ENG SMAD1 PMC5336551__F2 Chronic lymphocytic leukaemia MED12 BRAF MYC TRAF3 MYD88 IKZF3 FBXW7 EWSR1 TLR8 RIPK1 BCR ATM BIRC3 PTPN11 ASXL1 IRF4 CD19 CD14 LRP5 DDX3X BRCC3 CHD2 RPS15 CD79B CD79A XPO4 DYRK1A FUBP1 BCOR CARD11 MAP2K1 EGR2 CD22 LYN SYK TRAF2 ELF4 MGA GNB1 PMC6335096__F4 Peroxisome biogenesis PEX7 PEX19 PEX6 PEX5 GET3 PMC6335096__F5 Three mechanisms of pexophagy in mammalian cells TSC2 ULK1 TSC1 PEX6 PEX5 ATM PEX2 PEX10 PEX12 PEX26 RHEB NBR1 PMC4546491__F2 Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics SALL4 FGFR1 SOX2 NTRK1 GNAS DVL1 PMC6160397__F5 Proposed model for PD-L1 induction in CC PTEN WNK2 SOX6 PMC4095565__F2 NOD1 and NOD2 signaling cascades ATG16L1 NOD1 ATG12 TRAF5 UNK TRAF6 MAP3K7IP1 TRAF2 DKFZp686F0183 NOD2 TAB3 PMC7677640__F1 Mechanism of immune rejection caused by major histocompatibility complex (MHC) mismatch TH APC IFNG FOXP3 PMC9306018__F1 Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes TRPV4 SOST LRP5 LRP6 ARHA PMC6008220__F3 Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes TH CS IFNG PMC6705132__F7 Schematic model for BA-TPQ-induced MCF7 cell apoptosis ATF3 JUN DDIT3 PMC4985172__F2 Intracellular signaling pathways of EET’s EGF TRPV4 SRC STAT3 PMC6103459__F1 Cell cycle proteins mediating progression during MI MCC KNTC2 SPC24 APC ESCO2 SMC1B SPC25 PMC7573295__F1 UCA1 can enhance expression of AKT1 and activate it through phosphorylation MTOR HK2 STAT3 PMC5133678__F7 RBM5 targets in the EGFR Signaling pathway PDE1C PDE1B CLTA FOXO4 BAD PHLPP2 AP2A1 AP2A2 HEL-S-1 MAPK3 PRKAR1A ADAM12 NRAS TRIB3 CREB1 SPRY1 PDPK1 ADAM17 PRKCA CAMK4 PTPN11 CASP9 MAPK1 CDC2 FOXO3A CSK GSK3A PDE1A HRAS FOXO1 PRKACG SPRY2 CALM1 TSC2 MAP2K1 CDKN1A ADAM10 JAK1 RAF1 SOS1 SHC1 CRB2 PHLPP1 CDC42 PMC5260980__F4 Signaling pathways at the crossroad between autophagy and EMT RUNX2 DEDD SRC EIF2AK2 MTOR STAT3 PMC3901523__F3 Signaling pathways for inner ear proliferation and differentiation CDKN1A CDKN2D NEUROG1 ATOH1 CDKN1B NEUROD1 HES1 PMC5260980__F2 Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer EGF TNC JUP ZEB2 HEL113 PMC8522258__F4 Synergistic metabolic pathways that lead to a hyaluronan storm, NETosis, coagulopathy, and immune suppression STAT1 EGFR HAS2 SIRT1 STAT3 PMC2661888__F3 Hypergraph representation of the Boolean model for yeast glucose repression PCK1 CATIP GAL PMC8388496__F4 Comprehensive Transcriptomic Comparison between Porcine CD8− and CD8+ Gamma Delta T Cells Revealed Distinct Immune Phenotype PIK3R1 CX3CR1 TEC CCL3L3 TNFRSF11A CXCR6 CCL16 NCK1 IFNG TNFRSF9 TNFSF6 CD8B XCL1 PIK3AP1 GHR CD40LG ICOS CD19 TNF CD8A CD79B CXCR3 NFKBIA MAPK13 CD27 LCK SYK CSF1 VAV2 PMC2880865__F8 Revitalization of a diastemal bud FGF4 FGF3 FGF10 SHH SPRY2 PMC2895370__F1 TLR4 signaling: The MyD88-dependent pathway through PDCD4 TLR4 MYD88 PMC4597143__F4 Quantification of the full chemotaxis pathway PIK3R1 PRKCZ MAPK8 EZR WAS PDPK1 DOK1 CFI PRKCA ITK FYN TMSB4X PC INPP5D PIKFYVE NCKAP1 PTK2B PID1 SRC BRK1 MAPK1 HEL114 ARHGAP5 PREX1 RGS6 PARD3 ELMO1 RAPGEF1 ARHGEF4 ARHGEF1 MAP3K1 ARHGEF7 WASF1 HEL-S-28 CSK WASF2 BAIAP2 APC ARHGAP24 GNA13 OPN1SW DOCK1 ABI2 RGS2 RGS12 FERMT3 CRK PIK3R5 ZYX GRB2 GNAO1 NCF1 MYLK CDC42 S1PR2 BAD BRAF MAP2K4 ARHGEF2 PTEN RGS1 JUN FOXO3A S1PR1 ARHA MAP2K1 NFKB1 RELA PIK3CA DOCK2 PXN PMC3662220__F1 Novel zebrafish model reveals a critical role for mapk in lymphangiogenesis TSC2 TSC1 GRB2 PMC9498168__F8 MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway CCNA2 LEFTY1 LIN28A XPO5 CDK6 FOXC1 STAT1 CADM2 IGF2BP3 CADPS KRT5 RBL1 RBFOX1 IL1A FOS MAPK10 SCN8A GRIA2 DSCC1 THY1 CACNG8 GLRA2 HMGA2 CLSPN E2F7 GABBR2 CDKN2B GRID2 NR4A3 UNC13A GINS4 CKAP2 OPRK1 KLF2 SHISA9 SHCBP1 DEPDC1B DNA2 PMC7456945__F6 Simplified metabolic network indicating major pathways of volatile organic compound (VOC) synthesis and associated CO2 decarboxylation processes in the light PDC IPP PMC7595122__F1 Caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer CASP3 CASP9 IL1B FADD CASP5 GSDMD CASP4 BAX DFNA5 PMC9534090__F4 Emergence and dissemination of monkeypox, an intimidating global public health problem IRF9 APC EIF2A TRAF3 TRAF6 SYK IRF3 IFNG PMC7595122__F3 Graphical model of the effect of various molecules on caspase-3 dependent tumor cells death CASP3 CASP9 DFNA5 PMC12179916__F5 Myosin heavy chain 9 activates the Wnt/Beta-catenin signaling pathway to enhance the proliferation and survival of cancer cells MYH9 PMC11537654__F4 Homoharringtonine (HHT) enhances the proapoptotic effects of venetoclax by inhibiting the MAPK/ERK and PI3K/AKT pathways and activating the p53 pathway (orange line) ATM GSK3B MDM2 PTEN ATR PMC3705993__F1 LRP5, LRP6 and LRP4 are important components of the Wnt/Beta-catenin signaling pathway HBM LRP4 LRP6 SFRP1 DKK1 PMC8126980__F4 Ferroptosis in infection, inflammation, and immunity HMGB1 TBK1 CGAS IKBKE CHUK IKBKG MITA IRF7 IRAK1 TRAF3 TRAF6 IRF3 CCL2 MYD88 TNF TICAM1 IKBKB NFKBIA TLR4 AGER JUN TGFB1 STAT3 PMC8505885__F1 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations BCR PAX5 F2 TRAF3 MPC2 CD40 RRAS2 IRF4 HEL-S-133P FOXO1 HK2 STAT3 PMC3081180__F7 The participation of MCP-1, TNFA, MMP-9, E-cadherin, and Beta-catenin in macrophage fusion CCR2 MMP9 TNF PMC9393846__F1 Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity CGAS MICB APC MICA PMC4863308__F1 Hedgehog (Hh) signaling.Notes: Normal activation of the signaling pathway results from the binding of Hh ligand to the 12-transmembrane patched 1 (PTCH1) SUFU PTCH1 SMO PMC8505885__F2 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations TLR9 AHR BCR CD40 HIF1A STAT3 PMC6113163__F4 Signaling Pathway of Rho Guanine Nucleotide Exchange FactorImportant functions of this pathway involve antiapoptotic actions and regulation of actin-myosin interaction PIK3CD RTKN ROCK1 ARHGDIG HEL-S-15 CFL2 RHPN2 WAS RHO TNK2 MYBPH CIT PFN1 ARHGDIB ROCK2 LIMK1 ARHGEF1 MAPK10 PKN1 RPS6KB1 WASL IQGAP1 PIK3CA PIK3R2 CDC42 PMC11537654__F2 Homoharringtonine (HHT) causes phosphorylated eukaryotic initiation factor 4E (p-eIF4E) to SUMOize more fully SUMO3 CDK2 TRIM21 PLA2G2D ADAM10 PTEN EIF4E MTOR LPCAT2 HEL-S-5 PMC3446326__F1 Alterations in the FGFR signalling pathway that influence breast cancer FGFR1 FGFR4 FGFR2 PMC11537654__F3 Combination of homoharringtonine (HHT) and quizartinib inhibits the FLT3-AKT signaling pathway and its downstream targets (purple line) FLT3 MTOR BAX PMC11537654__F1 Homoharringtonine (HHT) directly binds the nuclear factor-kappa B (NF-KB) repression factor (NKRF) through the second double-strand RNA-binding motif (DSRM2), a nuclear localization signal for NKRF TSC2 TSC1 HOXA9 MEIS1 MYC PTEN FLT3 SP1 MTOR MAP4K1 TET1 PMC7339185__F12 Regulation mechanism of miR‐128‐3p in BCSCs PYGO2 CXCL16 EGFR NEK2 CD44 CD24 PMC4022581__F4 Transcriptome Profiling of the Theca Interna in Transition from Small to Large Antral Ovarian Follicles EPCAM NAT2 FRZB UBC AOX1 IL26 COL14A1 IL20RA SLC7A2 LIPG LTBP2 TSPAN3 STOX1 TESC NOSIP ATP1B3 XB NTRK2 PLXDC2 KLF6 CLDN11 APBB1IP WDFY4 EPHX1 CD44 TNF LTBP1 IL10RB PTPRE BCL2 ARNT2 PMC9483763__F1 Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy TSC2 NPRL2 TSC1 C16orf35 DEPDC5 PTEN RHEB PMC4041457__F4 The SDSA (synthesis-dependent strand annealing) and DSB repair sub-pathways GEN1 BLM RTEL1 SLX4 EME1 RMI1 PMC6349324__F1 Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model EGF MYC PMC8607427__F2 Post-translational modifications of CDK5 and their biological roles in cancer EGR1 CDK5 PMC8607427__F3 Post-translational modifications of CDK5 and their biological roles in cancer ATM CDK2 BIN1 EGFR EME1 CDK5 PDPN HCTP4 EZH2 H2AX STAT3 BAX PMC6743755__F3 Petri net–based model of the human DNA base excision repair pathway FEN1 INS PNKP PCNA PMC6810723__F4 Network structure of the 66 genes (left figure) and the top 12 selected genes listed in (right figure) from KEGG “Drug metabolism-cytochrome P450” pathway, extracted using the R package KEGGgraph CYP2B6 UGT1A9 MGST3 FMO5 CYP2A6 UGT1A5 CYP1A2 CYP2E1 MGST2 AOX1 CYP2C19 CYP3A4 UGT1A1 PMC3563076__F2 Molecules involved during pancreatic development PDX1 PTF1A OCEL1 NEUROG3 POU3F4 FOXA1 ECEL1 FGF2 PAX4 SOX9 MAFA FOXA2 PMC7602498__F1 Homocysteine (Hcy) metabolic pathway VIT PMC4900455__F2 Reciprocal antagonism by TLR4 oncogenic and TGFB tumor suppressor pathways IGF2BP3 YAP1 STAT3 PMC5962335__F4 Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration NAPRT NAMPT HEL-S-90n PNP NRK PMC3947295__F1 Scheme of the metabolic pathway of n-6 and n-3 long-chain polyunsaturated fatty acids FADS2 ELOVL5 FADS1 ELOVL2 GLA PMC8715940__F6 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes PIK3CD CHUK BAD CSNK2A1 GSK3B MTOR PDPK1 NOS2 JUN CTSL CAMK2D CTSK PSEN2 PTGS2 MAP3K5 TNF IKBKB CASP3 BIRC2 CHRM3 PSEN1 CTSC ERN1 GRIN2B PIK3CA CDK5R1 PMC9482625__F3 Cellular composition within the TME and the effect of EMT on TKI resistance EREG HGF CCL15 TWIST1 SMAD2 ZEB2 SMAD4 CCL2 AXL TGFA PMC8715940__F7 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes PIK3CD PPP3CA MAPK8 CSNK2A1 WNT1 MAPK3 GSK3B EIF2AK2 DKK1 FZD2 CASP9 MAPK1 CSNK1A1 NOS2 PSEN2 APC LRP6 TNF HRAS IRS1 CALM1 TNFRSF1A AXIN1 GRIN2B BACE1 EIF2S1 CHUK BAD INS MTOR ADAM17 INSR ATF4 ARAF PTGS2 DVL1 CASP3 MAP2K1 CHRM3 AGER PSEN1 NFKB1 PIK3CA CDK5R1 hCG_2014051 RYR3 FRAT1 PSENEN TRAF2 MME APH1B CYCS PMC6715281__F1 Wnt signaling pathways and the regulation by Wnt antagonists and the bone microenvironment APC SOST LRP5 VHL UNK LRP6 RYK ROR2 HIF1A PMC9393259__F1 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease GPX4 SLC7A11 HEL-75 PMC9482625__F4 Impact of tumor metabolic reprogramming on TKI drug resistance HGF HEL-S-30 FH EGFR PTEN SP1 PHGDH FASN CD36 PMC8715940__F5 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes BACE1 BAD CX3CR1 PTGS2 GSK3B MAP3K5 MTOR PDPK1 INSR CASP3 PSEN1 GRIN2B PIK3CA CDK5R1 AXL NTRK2 JUN MME CHRNB2 STAT3 PMC11955630__F9 Pathway analysis for CKS1B and related genes RIT1 IGF1R BRAF ALK EGFR NRAS PTEN CDKN2A FGFR2 RPTOR CHEK2 NF1 ERBB4 FGFR1 ATM PTPN11 MDM2 ARAF ROS1 NTRK2 KIT PDGFRA NTRK1 FGFR3 MAP2K2 RAC1 HRAS RHEB CBL TSC2 RICTOR RET TSC1 MAP2K1 ERBB2 STK11 RAF1 FLT3 SOS1 AKT3 PMC8170402__F2 Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy ATM BRCA2 RAD51 XRCC3 BRCA1 PMC3081924__F10 Model for SENP2-mediated modulation of Mdm2 in regulating p53 PML MDM2 SENP2 PMC7744508__F1 Central carbon metabolism network, which was implemented in the multi-level kinetic model of Synechocystis GCA TNLG7C HEL107 HPR PMC9393259__F2 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease TLR4 MYD88 IL1B PMC11989024__F3 Cellular signalings and mechanisms of integrin-mediated drug resistance in cancer cells EGFR SRC MTOR PMC6625751__F1 Type I interferon in rheumatic diseases CD14 CGAS TLR9 STAT2 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TNF TLR3 STAT1 TLR8 TLR7 TLR4 TREX1 TYK2 JAK1 IRF-1 MAVS PMC5649010__F8 Model for atypical MyD88-independent TLR7 signaling during Yersinia pestis infection TLR7 EEA1 MYD88 PMC5449407__F7 SAR signaling in maize inflorescence based on DEG analysis CAD PMC8929255__F4 Immune barriers in haematopoietic stem cell gene therapy CGAS ATM TNF IFNG PMC5153247__F8 Schematic diagram of Akt/Id2 signaling pathway in the neuron GIG8 CA3 PMC7729279__F2 Illustration of molecular signaling involved in SARS-CoV-2 infection TBK1 CGAS STAT2 IRF7 IRF3 IFNAR2 MYD88 IFNAR1 STAT1 TLR8 TLR7 ACE2 IL1B TMPRSS2 MAVS PMC12061301__F7 AKT1 regulating cuproptosis in TNBC tumorigenesis FDX1 DLAT PMC8591232__F2 Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators CXCL1 IL8RB IFNG STAT3 PMC4284697__F1 Summary of the p53 pathway TIGAR PML SCO2 MDM2 GADD45A DDB2 MSH2 SESN2 BAX PMC9356848__F7 Transmembrane Protein ANTXR1 Regulates Gamma-Globin Expression by Targeting the Wnt/Beta-Catenin Signaling Pathway APC CCND1 SOX6 PMC5095106__F3 TNFR1-elicited signaling pathways USP21 TRADD CYLD TNF TRAF2 FADD PMC8492288__F2 Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview GIG8 AHR TNF ID1 PMC8170847__F2 Developmental Pathway and Interconnectivity of Immunotherapy and Nanotechnology: NPS HEL-S-92n PMC9312905__F7 Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry TRPC6 TG STIM1 PMC8431116__F2 MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype LAT2 GPT GLS PMC5190058__F8 Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application GML BAX PMC8536196__F1 Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review CRH CRHBP MC2R FKBP5 SKA2 PMC7460555__F1 PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/Beta-catenin pathways BACE1 RS1 TSC2 TSC1 NGF APC LRP5 GRB2 LRP6 PTEN BDNF RHEB PMC6023907__F3 The BMP signaling cascade in osteoblast differentiation RUNX2 TWIST1 SMAD6 SMAD4 MSX2 TCF12 PMC3757225__F7 Mechanistic model of strain-induced fetal type II cell differentiation via integrin-TACE pathway EGFR HBEGF TGFA ADAM17 PMC6894473__F1 Schematic view of the Wnt signaling pathways between MSCs and HCC cells in inflammation microenvironment EPCAM APC MSC LRP5 LRP6 TERT ELL IFNG PMC3260150__F2 Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer BAD ADAM19 FPGT ST3GAL6 PMC6894473__F2 Schematic view of the TLR4 signaling pathways between MSCs and HCC cells in inflammation microenvironment TLR4 MSC LBP TRAF6 MYD88 TIRAP PMC6894473__F3 Schematic view of the AP-1 and PKB signaling pathways between MSCs and HCC cells in inflammation microenvironment BAD MSC TRAF6 PTEN MTOR PMC7503096__F1 Two common pathways implicated in thyroid cancer PTEN MTOR TERT PMC7699912__F1 Toll-like receptors (TLR)-mediated signaling pathway in keratinocytes CD14 TLR5 LTA TLR4 TLR9 IRF7 IRF3 TLR1 TLR3 PMC2956794__F1 Targeting DNA repair proteins for cancer treatment FEN1 ATM BRCA2 XPC RAD52 RAD51 XPA LIG1 BRCA1 PCNA PMC8441939__F1 Immune response to SARS‐CoV‐2 in children: A review of the current knowledge STAT2 IRF9 IRF3 PMC5904130__F5 Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist MTOR BDNF RHEB PMC10530696__F1 Deciphering the Enigmatic Influence: Non-Coding RNAs Orchestrating Wnt/Beta-Catenin Signaling Pathway in Tumor Progression APC SP1 BLACAT1 SOX4 PMC4583389__F3 Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma NRG3 BTC NRG4 PMC8838558__F7 One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue HEL-S-61p MTR PMC6317074__F1 Proposed cholesterol-lowering mechanisms of PS ABCG8 ABCG5 LDLR NPC1L1 ABCA1 ACAT2 PMC6834139__F2 ST2/IL-33 immune cells signaling pathway IL16 HGF IGF1 IRAK1 IL33 MYD88 CSA2 TGFB1 IFNG PMC9188347__F1 Metabolites as drivers and targets in rheumatoid arthritis HEL-S-133P HK2 ACOD1 PMC8990477__F2 CAR-T Cell Therapy for Breast Cancer: From Basic Research to Clinical Application MYC BCL2 MTOR PMC8998551__F4 Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution KIT RET PDGFRA FLT3 MTOR PMC2733795__F4 Regulation of STAT3 signal transduction pathway SOCS3 IL6R SOCS1 STAT3 PMC11544397__F6 ERS induces renal fibrosis in high-fat diet mice via the TGFB/SMAD pathway SMAD2 PMC4276042__F1 Targeting the PI3K pathway for cancer therapy TSC2 BAD TSC1 GSK3B MDM2 CCND1 ARHA PTEN RAC1 EIF4E RHEB BAX PMC9180737__F3 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease ARL13B CD133 STAT3 PMC9180737__F2 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease GLIS1 SNAI1 FGFR1 HEL113 PMC6750892__F11 Proposed mechanism for how AvB3 integrin signaling could be mediating fibronectin matrix assembly in TM cells HEL-S-28 SRC ARHA PMC11054193__F7 DEGs and DMs change following exogenous ABA therapy and UV-B stress in the R MVD FDPS DLAT HMGCR PMC7316593__F8 RSV induces Uric acid and leads to Th2 response IL13 IL33 HEL-S-92n CCL2 TSLP IL1B PMC3493902__F8 The diagram illustrates the possible mechanism of tumor cells-secreted CCN1 in regulation of pancreatic carcinogenesis through the regulation of SHh signaling CCNI SHH SMO PMC8093976__F4 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases PLXND1 DLL4 SEMA3E RHO RAC1 PMC5751130__F1 Regulation of the TGFB signaling pathway by miRNAs SMAD2 SMURF2 SMAD4 PMC5159651__F7 Suggested model for modulation of Wnt pathway by OCC-1 splice variants APPL2 APC APC2 PMC11274024__F6 Different cellular events in RG7388-resistant CLL samples XPC DDB2 TP53INP1 CDKN1A AEN BBC3 TNFRSF10D DRAM1 MDM2 ZMAT3 PHLDA3 TNFRSF10B PCNA BAX PMC8093976__F2 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases PLXND1 NRP1 SEMA3E SEMA3C PMC8093976__F3 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases PLXND1 NRP1 VEGFA SEMA3C RAC1 SH3BP1 ARF6 SEMA3D PMC8593325__F3 Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease PINK1 BDNF PARL PMC10454494__F3 Prostate cancer pathways [112] BAD TF MVP PMC5000709__F2 Kallistatin inhibits angiogenesis and inflammation through blocking VEGF signaling and NADPH oxidase activity PDK2 VEGFA SRC RAC1 PMC5000709__F3 Kallistatin inhibits Wnt canonical pathway induced angiogenesis and inflammation GSK3B LRP5 LRP6 RAC1 CDC42 PMC8437644__F7 Studies on the Role of circRNAs in Osteoarthritis CD47 CHAD CD36 PMC7415495__F6 Molecular mechanisms underlying Beta-cryptoxanthin inhibits A7-nAChR, thereby leading to the inhibition of lung cancer progression and metastasis COX2 BAD MMP12 MMP2 MMP9 BAX PMC4249256__F5 Illustration of the proposed crosstalk between insulin/IGF1 and IL-17 signaling pathways CXCL1 IGF1 CCL20 TRAF6 IL17RC PMC3730126__F1 Molecular mechanisms of cellular insulin resistance in muscle and liver DGAT1 DGAT2 LPL TG IRS1 UCP3 PMC4460810__F1 Wnt/Beta-catenin pathway regulates stem cell pluripotency and cell fate decisions during development APC MYC CD44 PMC5328691__F1 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance ELF2 ATF4 XBP1 PMC7415495__F3 Molecular mechanisms underlying Beta-cryptoxanthin prevention of cancer development/progression RARB BCO1 MMP2 MMP9 CCND1 HEL-S-133P SIRT1 PMC2689231__F6 Purine biosynthetic pathway, showing protein abundance changes for the P PURA PURB ADK PMC7162828__F1 Kynurenine pathway of tryptophan degradation HEL-S-90n KYNU AFMID PMC7388725__F2 Mitochondria and lysosomes in ferroptosis GPX4 STEAP3 FH CISD1 FES GLS2 STAT3 MAL PMC8778447__F1 Molecular Mechanisms Leading from Periodontal Disease to Cancer BRAF CCND1 STAT3 PMC3502626__F7 A theoretical model of synergistic interactions between resveratrol and HDAC inhibitors is presented CASP3 RELA CASP9 CASP8 SIRT1 PMC5328691__F2 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance ELF2 B3GAT3 CRELD1 PLK3 ATF4 ATF2 PMC7388725__F1 Ferroptosis in a cell LPCAT3 STEAP3 FACL4 GCLC HEL-S-64p ADA GLS2 IPP TF HMGCR PMC5938095__F8 TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus PC CA3 BDNF PMC3045483__F1 Interactions occuring in the ovarian mural granulosa cells (GC) and cumulus cells (CC) after the administration of hCG for ovulation induction EREG BTC PGR AREG GC MAPK3 MAPK14 MAPK1 PMC6628048__F1 Synthesis of bile acids (BA) CYP27A1 CYP46A1 CYP8B1 CYP7B1 CYP7A1 PMC3215729__F1 Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity PDX1 PLP2 PNP PMC3947125__F3 Schematic model of the autophagy pathway demonstrates several relevant markers of autophagy which are potentially influenced by a high cholesterol diet as well as possible points of regulation try resveratrol (RV) ATG12 LAMP2 MTOR DKFZp686F0183 PMC4533011__F1 iNKT cell activation pathways in sepsis CD14 CD1D SAG APC PMC6811614__F1 GCs affect cross-talk of bone cells and their communication with muscle, vasculature and myeloid cell-derived osteoclasts BAK1 SOST MSC DKK1 WIF1 PMC7720507__F6 Internalization pathway of PLGA-PEI PCS NPs in MSCs CD9 CD63 NPS EEA1 IMPACT CD81 PMC7175615__F5 Pathway of TGFB2-TLR4 crosstalk within the glaucomatous TM BAMBI TLR4 MYD88 PMC5256872__F7 Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells ROCK2 LIMK2 ROCK1 CREB3L3 FGFR3 BDKRB1 ARHA FGF13 FGF12 MAP2K3 FGD1 MAP2K6 PMC6368372__F1 Proposed mechanisms of action of glutamatergic modulators and other putative rapid-acting antidepressants EEF2K EEF2 GSK3B BDNF LHB PMC8965725__SF1 Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy CGAS NPS IRF3 PMC9526507__F2 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer HEY2 DLL4 NOTCH1 TNF FOXC2 PMC9526507__F1 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer MAML1 DLL4 ADAM10 DLL3 PMC7909764__F3 Senolytic therapies MDM2 CDK4 OXR1 BRD4 PMC5987016__F1 “Immune Gate” of psychopathology – mechanisms of gut derived immune activation leading to psychiatric manifestations TLR4 MOG CRH MBP LBP CD69 PMC4457640__F3 Protein Cys map to functional pathways based upon percent oxidation TUFM CCT4 SRC HEL-S-87p RAN FASN SNUPN HEL-S-69p PMC2901795__F1 Left: the EGFR pathway; Right: inhibition of the EGFR pathway by the EGFR monoclonal antibodies EGF EGFR TGFA PMC5799794__F1 Effects and underlying mechanisms of lncRNAs in various fibroses N4BP2 PLXNA4 ZEB2 FURIN MYD88 TGFB1 CFTR PMC7491749__F1 Ras Signaling Pathway GRB2 SOS1 PMC11019826__F8 Utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction–associated steatohepatitis EGR1 NEDD9 PMC7491749__F4 Overcoming Resistance to Drugs Targeting KRASG12C Mutation SOS1 HRAS AURKA PMC9347104__F1 Oxalate-induced apoptosis through ERS-ROS–NFKB signalling pathway in renal tubular epithelial cell ELF2 XBP1 PMC4892757__F1G MicroRNAs targeting TGFB signalling underlie the regulatory T cell defect in multiple sclerosis SMAD2 TGFBR1 TGFBR2 SMAD4 FOXP3 PMC11277110__F2 Roles of miRNAs involved in the developmental growth and apoptosis of Drosophila TSC2 TSC1 SKI RHEB PMC11277110__F4 Signaling pathways regulated by miRNAs in wing development SUFU APC SMO WLS PMC3648790__F4 Interplay Between the Cancer Genome and Epigenome HEL-S-26 PRC1 RBBP4 ASXL2 RBBP7 JARID2 EZH2 BAP1 PMC3213224__F3 Possible mechanism of reciprocal enhancement between innate and adaptive immunity, through NF-kB and STAT-1/IRF-1 pathway STAT1 CXCR3 CCR5 CXCL10 CXCL9 CCL5 PMC10959754__F4 Ubiquitination in TNF signaling RIPK1 TRADD CYLD SHARPIN RIPK3 CSA2 TNF OTULIN TRAF2 FADD MLKL TAB3 PMC11672279__S1 The brain‐targeting and therapeutic mechanism of T+A@Glu‐NPs against glioma NPS NOTCH1 BRD4 PMC6566291__F1 TGF-Beta-mediated skeletal muscle fibrosis SMAD2 TGFBR1 SMAD4 PMC4508827__F5 Toll signalling pathway of C LDLR TRAF6 CACTIN MYD88 SP1 FADD PMC4508827__F7 Jak-Stat pathway of C CDK2 PIAS1 CDK4 PTEN RAF1 PMC9476258__F2 The potential of plant extracts in cell therapy RUNX2 APC GRB2 SMAD4 SMAD1 DKFZp781O1323 PMC6688483__F4 Role of CRPs in AIBD HEL-S-62p DSG1 DSG3 CD55 PMC8136123__F5 Histone deacetylase-2: A potential regulator and therapeutic target in liver disease (Review) EGF HDAC2 PTEN MTOR PMC8184824__F6 HJURP in PCa cells CDKN1A GSK3B HJURP PMC5033061__F6 An integrative analysis of the InR/PI3K/Akt network identifies the dynamic response to Insulin signaling TCP1 RFC2 DGCR8 NCOR1 ELF3 AMOT DROSHA ENG RFC3 RFC4 PMC3770492__F2 A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway PRKCZ IRAK1 FOS CCL20 TRAF6 MYD88 TIRAP STAT3 PMC7576355__F5 FGFR axis, Ras-Raf-MEK and TP53 relationship to CDK4/6; FGFR results in activation of PI3K, Ras-Raf-MEK, STAT which increases cyclin D1, thereby promoting progression through the cell cycle CDK2 MDM2 CDK4 PMC7576355__F2 CDK4/6 pathway and FOXO3-FOXM1 axis: Cyclin D-CDK4/6 complex phosphorylates FOXM1 transcription factor which is involved in expression of G1/S phase genes FOXO3A FOXM1 CDK4 CDK6 PMC7598587__F7 Putative molecular pathway of catalpol in the skeletal muscle of type-2 diabetic mice in amelioration of glucose homeostasis and insulin sensitivity CS IRS1 SIRT1 PMC7576355__F3 Speckle-type POZ protein (SPOP) and CDK4/6 pathway CCND1 CDK4 SPOP CDK6 PMC7576355__F1 Androgen regulation of cell cycle and CDK4/6 pathway SRC MTOR TF PMC5972548__F2 Wnt signaling pathways RYK ROR2 RHO PMC2671988__F2 Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder NF1 TSC2 TSC1 PTEN GRM8 MTOR NAPG PMC8904414__F1 Different Pattern of Cardiovascular Impairment in Methylmalonic Acidaemia Subtypes CBLC CBL PMC9166238__F1 Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease PINK1 TFEB MTOR HEL-S-130P SIRT1 PMC8331109__F8 Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways EGF KIT FOS FGF2 EGFR MAPK3 VEGFA TNF INSR CASP3 TNFSF6 KDR RELA IL2 CDK4 JUN TGFBI PMC7139310__F1 PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases BACE1 ATF4 PMC7925768__F1 O-GlcNAcylation: the “stress and nutrition receptor” in cell stress response OGA CD2 TPR PMC7991810__F2 Signaling cascade of NC1-peptide that regulates spermatogenesis RPS6 MTOR CDC42 PMC8955086__F6 Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy NLRP3 NLRC4 GSDMD PMC9019367__F2 Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer SMAD2 APC SMAD4 PMC5098226__F1 Engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using unrelated carbon sources ACHE HEL-S-133P PMC3920946__F1 Serine, one-carbon cycle, glycine synthesis (SOG) pathway MTHFD2L SLC25A32 SHMT1 DLD NNT MTHFD1 MTHFD2 PHGDH GC DHFR PSPH GLDC HEL-S-70p HEL-S-51e AMT MTHFD1L PMC5242448__F1 Cell signaling transduction pathways controlled by WISP-1 in different cancer cells MMP2 MMP9 EGFR VEGFA NOTCH1 SRC PMC4600536__F3 Role of IGF-I Signaling in Muscle Bone Interactions BAD IGF1 FOS GRB2 MTOR JUN PMC2966895__F2 Complement-targeted therapeutics HEL-S-62p CD59 SMCP C4B_2 C1S C4A CR1 CP PMC6962593__F3 Toll like receptor 4 (TLR4)-dependent basal lung transcriptomics CCR5 DCLRE1A RETNLB GTF3C3 ZNF292 HCCS GPATCH8 NPEPPS GLIPR1 HECTD1 ZMIZ1 CEBPB BAG1 PPP1R15A TTC28 ISOC1 CCR1 DPH5 EPHB1 HTATIP2 DFFB PMM1 MRPS23 PUM1 opn DYNC1LI2 JUN IL1B CTSW EGR1 HRG AREG FOS PTGS2 ATF3 IL6 APBB2 EDN1 MMP12 MGA STAT3 PMC9030821__F2 RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma CXCL1 CXCL10 IL8RB CXCL3 CXCL2 CXCR6 CXCL13 CXCR3 CXCL16 CXCL17 CXCL6 CXCL12 CXCL14 CXCL11 PMC11624815__F9 Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity CD47 PMC4455348__F1 Schematic of HER3 engagedment in heterodimerization and signaling BAD GSK3B GRB2 MTOR HSF1 PMC6260778__F8 Effects of the metabolite, RA, on Tregs SMAD4 FOXP3 PMC6260778__F6 Hypoxia induces differentiation of T-cells to Tregs SMAD4 MTOR FOXP3 PMC6260778__F7 Low pH induces differentiation of T cell into Tregs SMAD4 PTEN STAT3 FOXP3 PMC6260778__F5 Microenvironment recruits Tregs to tumor tissue by chemotaxis CCR6 CCR10 CXCR4 CCL20 CCL28 CXCL12 FOXP3 PMC7971890__F8 JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination TBK1 RNF5 JMJD6 TRAF3 IRF3 MAVS PMC6260778__F3 Effect of glycolysis on Tregs FOXO3A MYC GCK FOXO1 FOXP3 PMC8657471__F2 EREG/EGFR Pathway in Tumor Progression EREG AREG EGFR SRC RAB27B MTOR HK2 STAT3 PMC10281733__F10 LPS-antagonist potential of Q3G on pulmonary injury NLRP3 TLR4 GSDMD BAX PMC8657471__F3 EREG/EGFR Pathway in Tumor Progression EREG EGF HGF AREG EGFR PMC6061846__F8 Signalling pathway that mediates TRPA1-dependent PMA induced by GTN TRPA1 ALDH2 PMC8538727__F2 Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects NAPRT NAMPT HEL-S-90n NMNAT1 KYNU KMO NMNAT2 AFMID NMNAT3 PMC8657471__F4 EREG/EGFR Pathway in Tumor Progression EREG ERBB2 AREG EGFR RAB27B CDH2 STAT3 PMC7352727__F7 KRAS promotes glycolysis, protein and lipid synthesis and one carbon pathway MTOR PMC8657471__F5 EREG/EGFR Pathway in Tumor Progression EREG BRAF EGFR PMC9548442__F1 Lighting the way to host-directed immunotherapeutics TBK1 STAT2 IRF7 IRF9 TRAF3 IRF3 IFNAR2 IFNB1 IFNAR1 STAT1 TYK2 JAK1 AXL PMC6905007__F2 LRF/ZBTB7A’s silencing compromises Warburg effect and induces apoptosis in cancer cells TIGAR ZBTB7A SCO2 HEL-S-30 BCL2 PFKP PMC7397197__F5 Nonautonomous replication stress response in the central nervous system TBK1 CGAS IRF3 TNF AIM2 PMC7233810__F5 Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism SQLE PMVK MVD DHCR24 MVK HSD17B7 IPP RHOB HMGCR PMC5641881__F1 Metabolic reprogramming in cancer cells under hypoxia HEL-S-26 FBP1 GYS1 ACSS2 HEL-S-133P L2HGDH FASN GLS PMC6278507__F6 Molecules associated with ‘focal adhesion’ pathway HEL-S-28 GRB2 SHE ARHA PTEN JUN PMC8047580__F1 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy PLG ACE2 TF PMC3044157__F6 The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage ECT2 NET1 RHOB PMC7430912__F5 KEGG pathway analyses of DESR genes expressed across multiple time points implicated the Adipocytokine signaling pathway as playing a prominent role in successful CNS axon regeneration LEP SOCS3 NPY AgRP LEPR MTOR TRAF2 NR1C1 STAT3 PMC8047580__F2 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy VCAM1 VWF TF PMC8047580__F3 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy PLG TRAF6 HIF1A MTOR ACE2 TLR3 TF PMC7991060__F1 Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action PTGIS PTGS2 PTGES PTGS1 PTGES3 PMC6691376__F8 Schematic model for the positive feedback loop between fibroblast activation and ECM deposition mediated by CD44-RhoA-YAP signaling pathway CS CD44 ARHA LATS1 LATS2 PMC8283805__F2 Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling EGF EGFR MTOR ELF4 ADAM17 STAT3 PMC8772830__F1 Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways HEL-S-67p KEAP1 IRAK1 TRAF6 IRAK4 MYD88 TNF PMC5072688__F5 Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects CASP3 EGFR STAT3 PMC11244889__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages SCAP2 NLRP3 c-fgr LYN LTB SYK STIM1 GSDMD PMC5833461__F7 EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection EZH2 DKFZp686F0183 PMC6501765__F2 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) LPA VIP MLN NPB PRSS1 CALCA SCT GIPR PMCH VIPR2 PTH2 NTS BDKRB1 PTH HRH3 CGA SCTR TACR2 NMBR SSTR5 GHRH NMU GHRL TSHR TRH FSHR PMC6501765__F3 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) IPPK SYNJ1 CDIPT PMC6497508__F2 Role of the classical and terminal complement pathways in cold agglutinin disease and target levels of complement inhibitors HEL-S-62p PMC4478296__F2 Mitogen-activated protein kinase (MAPK) signalling pathway KIT EGFR GRB2 MTOR PMC3625556__F7 The possible molecular mechanisms of pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis in rats CCND1 BAX PMC4107162__F1 Mechanisms of cellular invasion by intracellular parasites HEL-S-62p CR1 PMC4702801__F1 Snapshot of Colorectal Cancer Atlas features PTMS HEL-S-11 LAT PMC10970282__F8 Construction of the potential miRNA-target negative correlation regulatory network involved in the FoxO signaling pathway following G CTSL TRIM63 FBXO32 BNIP3 PMC9523361__F5 Tuning Rex rules HTLV-1 pathogenesis ATF2 CTRL IL2 IFNG PMC7159149__F6 Commonly dysregulated genes EGF HRG CS TRADD APC MTOR LTA CD27 CRP AHSG IL17A MOK CD40 ECSIT BAG2 STAT3 PMC9496762__F2 Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis TRIM11 TRIM45 SOX2 EGFR TRIM21 TRIM8 MTOR TRIM13 TRIM32 RELA TRIM28 TRIM24 TRIM44 TRIM47 TRIM37 MAGEA6 STAT3 MAGEA3 PMC5525000__F1 Schematic representation of sulfides (H2S) synthesis and oxidation pathways SQOR HEL-S-64p PMC4211077__F2 Advances in understanding of bile acid diarrhea FGF19 FGFR4 PMC3774122__F2 NRF2-mediated oxidative stress response pathway PRKCI DNAJC19 GCLC FTL VCP HMOX1 PMC2937358__F1 ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches EGFR CXCL6 CXCL3 CXCL2 PMC10298409__F11 Integrated Transcriptomics and Metabolomics Analysis of the Fructan Metabolism Response to Low-Temperature Stress in Garlic GLA PMC9685423__F1 Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry CYP27A1 AMACR HSD3B1 H1-3 CYP11A1 CYP7B1 SLC27A5 PMC7432057__F1 Mechanisms involved in the effects of adiponectin in different liver diseases including hepatic I/R TLR4 FGF2 CRP LCN2 RBP4 TRAF6 HEL-S-44 SAA1 MYD88 SIRT1 UCP2 STAT3 PMC7432057__F3 Adiponectin and leptin in the progression of nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) SOCS3 MTOR STAT3 PMC7408019__F6 KLF4 acts as a negative regulator of wt-CFTR but has its function disrupted in the F508del–CFTR cells BAG3 GSK3B KLF4 CFTR PMC6439804__F1 Hedgehog-Induced Osteogenesis SAG MSC GLI3 SMO PMC5343808__F1 Sonic Hedgehog Pathway: Shh acts on Ptch to inhibit the repression of Smo by Ptch SUFU MYC SMO PMC5343808__F2 Wnt Pathway: In the presence of Wnt ligands, Dsh blocks the Beta-catenin destruction complex consisting of Axin, APC, CK1, GSK3B MMP7 APC GSK3B MYC CCND1 NEUROD1 PMC6540809__F1 B cells mediate MS pathology through antibody-dependent and antibody-independent mechanisms CXCL13 LTA PC LTB PMC8371405__F2 Long Non-coding RNAs on Bladder Cancer ZEB2 FOXQ1 TUG1 DNMT3B PMC7059628__F8 Comparison between wild‐type and gas7‐knockout neurons of mitofusin regulation by the PINK1 and parkin‐mediated mitophagy pathway MFN1 PINK1 MFN2 GAS7 CDK5 PMC8371405__F3 Long Non-coding RNAs on Bladder Cancer E2F4 SOX2 HNRNPL GSK3B SMAD4 CCL2 EZH2 REL TET1 PMC2923369__F2 Auto-layout of ‘Caffeine (C) neighborhood’ based on Ingenuity curated finding (IPA, Ingenuity® Systems) LEP NPY CRH PMC4548197__F1 Neuronal apoptosis network CASP3 BAD MDM2 CASP9 BCL2 BAX PMC6381369__F1 An illustrated view of Netrin-UNC5B signaling ALPL PRKCA HEL-S-11 DCSTAMP RGMA JUN CALY SELE PMC5729908__F9 m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway IL7 METTL3 IL7R JAK3 JAK1 PMC4323367__F7 Summary of radiation-induced persistent alterations of IGF1 and leptin signaling pathways observed in our study IGF1R IGF1 IRS1 PMC8745001__F4 Cytosolic Quality Control of Mitochondrial Protein Precursors—The Early Stages of the Organelle Biogenesis ATF4 EIF2A OMA1 UBR1 ATF5 HSF1 PMC139865__F12 Innate immunity pathways in Drosophila NFKB2 NFKB1 TRAF6 REL PMC4101637__F10 Working hypothesis on the distinct mechanisms by which TNFA/IL-1B and IL-6 inhibit the hepatic GH-IGF-I pathway during inflammation GHR IL1B PMC10215516__F2 PI3K/AKT/mTOR signaling pathway activation in HPV-positive HNCs PTEN SLPI MTOR PMC4258093__F3 Canonical Wnt signaling APC AXIN1 PMC4030405__F1 Complement system HEL-S-62p C9 C7 C6 C1S CP PMC8847026__F12 “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer PC CIC CPT2 NNT ACLY PMC5903427__F1 Purine salvage pathway and HGprt function () ADA ASL PNP PMC4258093__F1 PI3K signaling TSC2 RICTOR TSC1 PTEN MTOR IRS1 RHEB PMC8509287__F2 Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis IRF3 MYD88 MAVS PMC3770093__F1 Sphingolipid biosynthetic pathway GAL GBA2 PMC6111072__F10 Schematic Diagram Illustrates and Summarizes the Role and Signaling Pathway of PAK1 in Regulating Human SSCsPAK1 is mediated by EGF, but not by GDNF or FGF2; PDK1, ZNF367, and KDR are the targets of PAK1 EGF PAK1 KDR FGF2 EGFR GDNF ZNF367 PMC8207884__F4 Correlation Between the Evolution of Somatic Alterations During Lymphatic Metastasis and Clinical Outcome in Penile Squamous Cell Carcinoma KIT RICTOR TSC1 ATM ALK SOST APP PTEN HRAS MTOR ARAF NRK PMC10486691__F6 Association of EN2 with ERBB, insulin, BCR-ABL and JAK signaling RAPGEF1 BAD STAT2 GFAP MYC MTOR CRK CRKL CBL STAT1 PIM1 GAB2 PTPN1 STAT4 MDM2 GRB2 MCL1 JUN STAT3 PMC7397749__F1 Synthesis and metabolism of PUFAs PC LPCAT3 FADS2 SAG ELOVL5 FADS1 LPA ELOVL2 MBOAT7 PMC7500861__F5 Metabolic pathway differences between LLO118 and LLO56 and identification of mGPD2 as a candidate gene PIK3CD PLCG1 ACACA UCK2 UMPS PLD3 ST3GAL6 PLOD2 ALAS1 CMAS GLO1 NANS GOT2 ACSS1 ADSL PNPLA7 GPCPD1 HGSNAT PAICS GLYCTK LPCAT4 GPD2 CAD PIGA HAT1 PFKP PGAM1 PPT1 HK2 PIGL SDHB FASN ALDH9A1 ENO3 ME2 HEXA HEL-S-30 DLD PHGDH AGPAT5 HEL-S-68p CDIPT ACADL PSAT1 PMC7761926__F1 General view of canonical and non-canonical Wnt signaling ZNRF3 RNF43 ATF2 APC GSK3B LRP5 LRP6 ARHA RAC1 GPR49 ROR1 DAAM1 ROR2 JUN CDC42 PMC7736362__F1 Rewiring yeast metabolism to synthesize products beyond ethanol PDC CIT PMC5612418__F3 Neuroprotective actions of perinatal choline nutrition ChAT MTR MAT1A CHDH PMC3467082__F1 Translation of glutamine codons in yeast UACA GC PMC6415285__F2 Statins on several pathways involved in bone metabolism BMP2 CCL2 PMC11979612__F12 Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway BNIP3 DKFZp686F0183 OPA1 PMC7761926__F2 Wnt targeting agents for the Wnt/Beta-catenin signaling pathway ZNRF3 RNF43 TNIK APC NOTUM GSK3B LRP5 CER1 LRP6 TNKS PORCN GPR49 WIF1 PMC9619093__F2 Joint together: The etiology and pathogenesis of ankylosing spondylitis RORC TLR4 SOCS3 RUNX1 IL24 SOCS1 STAT3 PMC7158891__F3 An integrated overview of the immunosuppressive signaling pathways involved in the interaction between exosomal PD-L1 and T cells PPL LCK ZAP70 CD80 TNF CD69 PMC8875594__F1 PCSK9 Promotes Cardiovascular Diseases: Recent Evidence about Its Association with Platelet Activation-Induced Myocardial Infarction PCSK9 IL1A LDLR SRC CD36 PMC4707198__F5 Schematic illustration of Hog1-mediated posttranslational and transcriptional hyperosmotic stress response pathway SLN GPD1 PMC1479092__F1 The mitochondrial generated ROS-mediated activation of the p38 MAPK stress response pathway ATF2 ATF1 JUNB JUN TF PMC2892298__F8 Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors SOX11 SOX12 SOX4 TEAD2 PMC7849354__F2 Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling F7 PMC7849354__F3 Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling HBM F7 PMC4748038__F2 Shigella exploits Ca2+signaling to delay cell death and to dampen inflammation CASP3 NOD1 GADD45A BNIP3 CASP4 BAX PMC3296768__F5 Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis RARB FOS TES SLC10A2 NRCAM SKI PMC6580952__F1 Salient features of EBV latent transcripts during B-cell transformation, followed by B-cell lymphoma development E2F6 ATG3 TRADD DKFZp686F0183 CDK6 CCND2 BCL6 PIM1 BCR PAX5 CDK2 MDM2 CCND1 BCL2 CD40 ATR IRF4 PMC7443136__F8 TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury NLRP3 TLR4 MYD88 COL1A1 GSDMD PMC2586899__F4 The involvement of TNFAlpha-mediated signaling pathways in insulin resistance TSC2 TSC1 MTOR IRS1 PMC7927199__F9 Proposed schematic model summarizing the role of GNL1 as an antiapoptotic protein BCL2 HEL-S-107 BAX PMC3324360__F5 Simplified TGFB pathway BAMBI TGFBR1 ATF3 ID1 DDIT3 PMC7554781__F2 Glial cell line-derived neurotrophic factor family ligands (GFLs) signaling RET FYN GDF15 GDNF SRC PSPN ARTN NRTN PMC4064060__F4 Molecular interactions between Wnt/Beta-catenin and PPARG signaling in colorectal cancer cells APC GSK3B CCND1 PTEN PMC9438157__F9 M6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway GEM ALKBH5 MTOR DDIT4 SMG5 PMC9370682__SF1 Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway H1-6 H1-8 HIST1H1E H1-1 H1-0 H1-3 H1-2 H1-5 PMC12234474__F5 Targeted Therapeutic Strategies for PDAC HEL-S-308 MTOR HEL-S-162eP PMC4402390__F6 Metabolic network of CcsR-dependent targets and influence on cell regulatory networks COX1 CYC1 PMC8438693__F3 Protein phosphatase 2A in kidney disease (Review) TRADD TRAF2 FADD PMC4064060__F1 The Wnt/Beta-catenin signaling in epithelial cells ROCK2 APC LRP5 CD44 UNK CCND1 LRP6 ROR2 RHO PMC6614411__F4 Pathway-based analysis for glycolysis, TCA cycle and pentose phosphate pathway AIP MALL ATM PGC RPE MAL PMC9170957__F2 From Therapy Resistance to Targeted Therapies in Prostate Cancer EGFR SRC TF PMC1236698__F2 Molecular mechanisms of autophagy PI3 ATG12 ATG3 ATG10 ATG14 DKFZp686F0183 PMC6071982__F4 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny SCARB1 ACACA HELZ2 DAGLA ACOX1 FASN PMC5479302__F8 Proposed signaling pathway activated by CTS in CCA cells.Notes: The potential mechanism of apoptosis induced by CTS in HCCC-9810 and RBE cells STAT3 BAX PMC9370780__F11 Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes HEL-S-62p CD14 GBP2 GFAP SERPING1 TGM1 THBS1 AMIGO2 BDNF PBX3 SYP PMC12128267__F9 Proposed mechanism of gastrointestinal exposure to SiO2 NPs induced AD-like neurotoxicity HDAC3 NPS HDAC1 PMC2743935__F5 Calcium signalling and cell-fate choice in B cells REST TRPM5 PMC10556522__F2 Genomic rearrangements that contribute to pathogenesis of ALK- ALCL () represents ALK- ALCL harboring DUSP22-rearrangement and associated signaling pathways BATF3 CD58 ANKRD11 TBL1XR1 MYC ERBB4 IKZF1 NFKB2 IRF4 ROS1 MLL2 NCOR2 WWOX PMC6071982__F5 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny CTH MTR OPLAH HEL-S-64p HEL-75 MSRA PMC6744711__F2 Cross-talk between DNA damage and immune response CGAS ATM IRF3 ATR IRF-1 PMC8450340__F8 Qiangjing Tablets Regulate Apoptosis and Oxidative Stress via Keap/Nrf2 Pathway to Improve the Reproductive Function in Asthenospermia Rats MAF KEAP1 RBX1 JUN PMC6591470__F2 Schematic illustration of the cell type-specific effects of impaired PI3K-Akt signaling in AD brain IL1A GSK3B MTOR BDNF PMC7151139__F1 BMP signaling pathway SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC9113095__F8 Genetic evidence for the requirements of antroquinonol biosynthesis by Antrodia camphorata during liquid-state fermentation COQ3 COQ2 COQ5 PMC10556522__F1 Pathogenic signaling pathways in ALK+ ALCL () represents deregulated T-cell receptor signaling pathways mediated by NPM::ALK BAD ATL1-beta ALK IL9 IL17F CD48 CD244 MTOR STAT1 ITK IL26 FYN IL22 HDAC2 MSH3 IL4 MSH2 GATA3 ICOS IL10 SQLE IL13 IL6 IL23R HDAC1 LEF1 IL7 LCK ACLY OSM STAT3 PMC6591470__F1 Schematic presentation of PI3K-Akt intracellular signaling GSK3B GRB2 SYK PTEN PMC8280023__F3 Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment MFN1 FIS1 OPA1 BAX PMC5845444__F2 13C metabolic flux analysis of E PTS TAC3 CIT HEL107 MAL PMC2933224__F1 Gradient Descent Optimization in Gene Regulatory Pathways CASP3 CASP6 TRADD CASP9 CASP2 FADD CASP4 PMC8945569__F2 Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review NLRP3 IL1B PMC6467375__F5 PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation PDE3B TG PMC4586249__F3 RecQ helicases in base excision repair (BER) and double-strand break repair (DSBR) IL1A BLM PARP1 RMI2 LIG1 RMI1 UNG APTX WRN MPG NEIL1 FEN1 POLE RAD52 RAD51 OGG1 PNKP DNA2 PCNA TDP1 PMC2562925__F8 Schematic depicting the roles of p53 and wnt7b in proposed pathway for NGF-mediated neurite outgrowth in PC12 differentiation NGF FZD7 WNT7B FZD9 PMC7985079__F1 Modified model of the HMA-induced viral mimicry in leukemic cells RNASEL RNASE1 IRF7 IRF9 MAVS PMC4266699__F1 HER family and EGFR signaling pathway EGF EGFR HBEGF MTOR TGFA PMC7397772__F1 Apolipoprotein E (APOE) exhibits both proinflammatory and antiinflammatory properties NLRP3 TLR4 CXCL5 LDLR MYD88 IL1B APOE PMC4475926__F9 COX-2 increases insulin signaling by downregulation of miR-183 DGCR8 DROSHA DDX5 IRS1 PMC10874461__F5 Pathological mechanisms of osteoporosis induced by diabetes, glucocorticoids, and psychological stress NMU NPY CRH SOST MSC GC IGFBP2 PTH GIP GHRH PMC10874461__F2 X-linked osteoporosis in males APC LRP5 VWF LRP6 PMC5776968__F5 Signaling pathway responding to oligodeoxynucleotides of class C TBK1 CGAS TLR9 IRF7 IRF3 MYD88 TNF BTK BCR LYN SYK AIM2 IL1B MAVS PMC6636046__F7 Enriched KEGG pathways generated by ClueGO and Cluepedia NOTCH2 HHIP HLA-E CGAS AREG EGFR NRAS RNASEL GDPD1 GABRB3 PLA2G12A ARPC2 SDC4 SLC44A1 EML4 GNG2 CD80 HEL114 GNAO1 GNAS PPARG PMC4751379__F8 Ingenuity pathway analysis of GH signaling after hepatectomy STAT1 SOCS2 SOCS3 IGF1 A2M IGF2 SOCS4 SOCS7 CEBPA IRS1 SOCS1 STAT3 PMC9014242__F8 Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4 MAJN PKD1 JAK3 JAK1 PMC4706435__F6 MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway ROCK2 ROCK1 ARHA SP1 PMC4499589__F7 EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury TLR4 EPHA2 IL1B PMC3141988__F6 An E-cadherin–mediated Hippo signaling pathway LATS1 LATS2 PMC8686226__F3 Developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers TBK1 CGAS ATM IRF3 CTLA4 ATR BRCA1 IFNG CCL3 PMC9272524__F3 Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance ACO2 MTDH SIRT3 PMC4083693__F1 Wnt signaling is required for long-term memory formation APC TEF CDH2 PMC4292235__F1 Assembly and mechanism of action of CpG ODN/Tat nanorings PDC TLR9 MYD88 IFNG PMC3306972__F1 ABPP processing, the adaptor proteins interacting with its intracellular domain and the pathway leading to ERK1/2 activation NUMB GRB2 APP PMC9204553__F4 CTRP9 overexpression attenuates palmitic acid-induced inflammation, apoptosis and impaired migration in HTR8/SVneo cells through AMPK/SREBP1c signaling TSC2 F2 INS GLA RHEB CFTR CD36 HEL-S-5 PMC5685850__F4 Wnt receptor signaling pathway and regulation of Rab GTPase activity involved in miRNA expression RUTBC1 TBC1D16 MAPK9 BTRC SMAD4 PRKACG DVL3 PRKCA CREBBP NFATC2 NR1C2 SFRP1 CTNNBIP1 VANGL1 FRAT2 TBC1D28 TBC1D17 PMC11641400__F3 HA35 enriches signaling pathways involved in growth and antioxidant response in the developing murine intestine UBE2F RPS27A MDM2 UBA3 UBE2B MTOR SUMO1 PMC5664070__F3 An overview of signaling cascades involved in PLK1-induced EMT PLK1 FOXM1 ZEB2 GSK3B PMC6687767__F1 Natriuretic peptide signaling in adipose tissue UCP1 NPS ATF2 GC PMC8620858__F1 Hypoxia: The Cornerstone of Glioblastoma SOX2 EPO UBXN7 ELOC VHL NOTCH1 PTEN BNIP3 MTOR RBX1 HEL-S-133P PMC5014572__F3 Roles of MAS-related G protein coupled receptor-X2 (MRGPRX2) on mast cell-mediated host defense, pseudoallergic drug reactions and chronic inflammatory diseases MRGPRX2 EPO MBP NPS ORAI1 PMC12121061__F8 Schematic model illustrating the mechanism of combined treatment of VEN and C-82 CASP3 DFNA5 PMC9150122__F1 Biophysical Survey of Small-Molecule Beta-Catenin Inhibitors: A Cautionary Tale MMP7 LRP5 CCND1 LRP6 BCL9 PMC3890705__F6 Proangiogenic mechanisms activated in the omentum during transcoelomic EOC metastasis in the presence of anti-VEGF therapy CXCL16 HGF TIMP1 PF4 MMP9 IGFBP7 VEGFA IGFBP2 PMC8622675__F2 Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis? SRC LATS1 LATS2 PMC8371277__F2 Lipid droplets and lipid mediators in viral infection and immunity LTB TG PMC3071916__F2 Insights into the Pathogenesis and Treatment of Cancer from Inborn Errors of Metabolism HEL-S-26 FH PMC7139621__F1 Therapies fighting breast cancer through the fibroblast growth factor receptor (FGFR) pathway FRS2 GRB2 CDK4 MTOR PTX3 PMC5983188__F1 Cytokine/long noncoding RNA (lncRNA) interplay in controlling immune cell development and function BST2 PTGS2 CXCL8 CCL5 TNF PMC4581295__F2 Signal pathways of chondrocyte hypertrophy IHH RUNX2 BMP2 APC FGF2 GSK3B SMAD1 DKFZp781O1323 SOX9 BMP4 FRZB PMC6509841__F7 DEGs relevant to the “protein processing in endoplasmic reticulum” pathway under group “D vs ELF2 UBC ATF4 EIF2A SVIP SKP1 CP SELL BAX PMC3064560__F3 Analogue 3 also showed potent antiproliferative activity against the highly invasive non-small-cell lung cancer cell line CL1-5 with an ED50 value of 0.11 μM ZW10 RCC1 HCTP4 CDC2 RAN PMC11083511__F1 Subsets and functions of CD4+ T cells AHR IRF4 GATA3 BCL6 FOXP3 PMC5715135__F7 Canonical pathway of molecular mechanisms of cancer from IPA showing dysregulated mRNA targets along with their potential differentially expressed miRNA regulators found in Lebanese samples BAD WNT1 MYC CRK LEF1 MAX FRK SUFU GRB2 UNK ATR RBL1 BAX PMC8393536__F1 Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification ALK CRIPTO SMAD2 MSTN TNF PMC8303169__F2 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer RELA RELB TNF PMC12237497__F10 Working model of GPR120 modulation of mammary gland function TLR4 ACACA CXCR4 CTCF TRAF6 CXCL14 FASN CD36 PMC8303169__F3 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer EGFR STAT3 PMC10512452__F6 IL-10 Exerts anti-inflammatory effects through STAT3 signaling pathway TLR4 MYD88 JAK1 STAT3 PMC10558228__F1 NFKB signaling pathway and targets of inhibitors against neuroinflammation in AD CD14 ADIPOR1 TLR4 TRAF6 MYD88 TNF PMC6727029__F2 Pre-synaptic and post-synaptic mechanisms regulated by PPT1 FYN VAMP2 SNAP25 GAP43 CRMP1 PPT1 PMC10558228__F3 NLRP3 signaling pathway and targets of inhibitors against neuroinflammation in AD NLRP3 TLR4 GSDMD PMC10558228__F4 PPAR, STAT3 and PI3K/Akt signaling pathways and targets of inhibitors against neuroinflammation in AD PTEN TNF STAT3 PMC10558228__F5 Targeting inflammatory signaling pathways with drugs shows promise in AD treatment NLRP3 APP C6 STAT3 PMC11908107__F8 LXR-alpha agonist is involved in various biological functions in liver transplants TNF MTOR PMC7264106__F1 TNFR1 and TNFR2 signaling pathway TRADD TRAF2 FADD MLKL PMC4201175__F1 Biochemical and genetic processes in malignant mesothelioma NF2 MDM2 PTEN BAP1 PMC6466115__F1 Biosynthesis pathway of histo-blood group antigens (HBGAs) by stepwise addition of monosaccharides to precursor structures hCG_1998026 FUCA1 FUT3 PMC5499698__F1 mTOR-signaling pathway: mTORC1 and mTORC2 complexes and the key signaling nodes that regulate mTORC1 and mTORC2 TSC2 TTI1 RICTOR TSC1 GRB2 PTEN MTOR DEPTOR RHEB MLST8 PMC7230684__F1 Folate metabolic pathway disrupted by methotrexate (MTX) SLCO1B1 DHFR TYMS SLC19A1 PMC5499698__F3 Alterations in mTOR signaling pathway on spermatogenesis TSC2 TSC1 PTEN RPS6 RHEB PMC7286861__F6 The PGD2–GPR44 axis in human islets exposed to hyperglycaemia and proinflammatory cytokines PDX1 GSK3B FOXO1 MAFA PMC8820546__F2 AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin TSC2 TSC1 IGF1 ATM CCND1 RHEB BAX PMC5454408__F2 HBV modulation of innate immune sensors PDC TLR9 UNK RIGI MYD88 EZH2 TLR1 AIM2 TLR3 MAVS TIRAP PMC3254670__F1 Metabolic connections during apoptotic cell engulfment MFGE8 C1QB MERTK ABCA1 AXL UCP2 CD36 PMC8578102__F1 Transforming Growth FactorB and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment TWIST1 SMAD2 SMAD6 SMAD4 ARHA SKI PMC6220063__F1 Eicosanoid biosynthesis and PGE2 signaling via EP receptors COX1 HEL-S-11 PMC4600637__F1 Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia LIMK2 PAK1 LIMK1 CDC42EP4 CDC42EP3 HEL-S-47e CDC42 PMC6554373__GA Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level EPO BCL2 POR BDNF PMC10374743__F2 Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells HEL-S-133P HK2 HEL-S-162eP PMC8581319__F1 Epithelial‐Mesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs EGF HGF IGF1 ANXA2 HEL-S-15 SRC STAT3 PMC8086286__F2 Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis FOXO4 SNAI1 HOXA4 MYC FGFR3 BMI1 CCNE1 TIAM1 GADD45B DUSP5 SPI1 BBC3 CAMLG BIK PIDD1 NOTCH1 HOXA1 MAP3K8 EZH2 EPHA2 PMC6873590__F1 Glycolysis and biosynthetic pathways emanating from glycolysis TH MTHFD2L SHMT1 PSPH MTHFD1 GLDC HEL-S-51e MTHFD2 HEL-S-162eP PMC7253636__F1 Human pathway of assembly of lipoyl moieties on its cognate proteins LIPT2 LIPT1 LIAS GCSH PMC6328441__F4 Mechanism of CHOP regulation in ER stress induced apoptosis ATF4 EIF2A UNK ATF3 BAG5 TRAF2 BAX PMC3654194__F1 Spatial and temporal organization of ubiquitin networks TRADD IRAK1 SHARPIN TRAF6 CD40 IRAK4 MYD88 MAP3K7IP1 TRAF2 PMC6328441__F1 Upstream regulatory pathway of CHOP ATF4 EIF2A PMC3504431__F1 MTOR pathway TSC2 ULK1 TSC1 GRB10 DEPTOR IRS1 RHEB PMC7779329__F3 SARS-CoV-2 and relevant biological processes that involve ACE, PGR, FXIIIB, and tPA PLG PGR ACE2 TMPRSS2 PMC4889230__F1 The stress-triggered signaling pathway leading to DNA damage and cell death MGST2 NOX4 PMC4967197__F5 Peroxisome proliferator-activated receptor (PPAR)-related fasting response in heart HADHB NR1C1 TXN CFD PPARGC1A HEL-S-273 HEL-S-44 ETHE1 HEL107 PPARG HEL-S-133P DLAT CPD PMC7215285__F3 Metabolic pathways including glycolysis, pentose phosphate pathway, tricarboxylic acid cycle, and lipid synthesis with target non-coding RNAs FH ACLY HEL107 HEL-S-133P HK2 PMC4655822__F3 Establishment and Dysfunction of the Blood-Brain Barrier CDH2 PMC11678534__F2 Creatine in the promotion of cancer malignancy SMAD2 SLC6A8 JUN HEL-S-20 HEL-S-29 HK2 BAX PMC7039327__F2 B-cell receptor signaling triggers formation of a multicomponent “signalosome,” which can activate BTK, AKT, PI3K, PLCG2, and BLNK, and CD19, a coreceptor important for PI3K activation BTK ARHG BCR BASH LYN ARHA SYK PLCG2 RAC1 CD79B CD79A CD19 PMC9080378__F7 Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen BCL2 FGFR2 SOX9 PMC3753040__F1 Chromatin Recruitment of DNA repair proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways FANCD2 BRCA2 FANCM FANCL FANCA ATR FANCB BRCA1 FANCE FANCG USP1 FANCF PMC6450717__F7 Loss of CHP1 rewires glycerolipid metabolism in proliferating cells GNPAT ABCD3 GPAT4 PC CHP1 LPA TG PMC3880903__F8 Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human ABCC3 ABCC2 PMC9403138__F3 Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease NLRP3 CXCR1 CCR2 CX3CR1 CCL2 CCR1 PMC9332593__F2 DNA Damage Response Regulation by Histone Ubiquitination RNF168 RNF8 BARD1 BRCA1 PMC8131681__F2 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies NFATC1 SMAD2 TRAF3 TRAF6 MAP3K7IP1 PMC11647263__F6 In SAE, Nogo-A plays a critical role through a series of complex signaling pathways NLRP3 IRF3 TNF PMC8131681__F1 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7469280__F2 TRAF6 mediates signaling transduction pathway BAD TRAF6 ECSIT MYD88 MAP3K7IP1 PMC7469280__F3 TRAF6 regulates tumor related to signaling transduction pathways MMP9 LRP5 TRAF6 CD40 ECSIT PMC9563021__F7 Baicalin Modulates Inflammatory Response of Macrophages Activated by LPS via Calcium-CHOP Pathway STAT1 PTGS2 NOS2 PMC4759477__F3 Platycodin D‐induced G2/M phase cell cycle arrest in cancer cells WEE1 CCNB1 MDM2 CDC2 PMC6290461__F2 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases RAD51 PARP1 PCNA PMC6290461__F1 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases ZMPSTE24 IL6 MTOR PMC3926427__F4A Targeting Fibroblast Growth Factor Pathways in Prostate Cancer FGFR1 FGF2 FGF10 FGF8 FGF9 PMC9553876__F1 Molecular pathway changes caused by TTFields on glioma, GBM, MPM, NSCLC, and breast cancer Fig. 1A, Gliomas and glioblastomas CGAS ARHA MTOR AIM2 BRCA1 PMC7929421__F2 Unfolded protein response pathway ATF4 EIF2A BCL2 TRAF2 XBP1 PMC9553876__F2 Molecular pathway changes caused by TTFields combined with radiotherapy or drugs in GBM, MPM, NSCLC, and breast cancer FANCD2 FANCA JUN BRCA1 STAT3 PMC7929421__F3 Immune response activation pathway TBK1 IRF7 TRAF3 TRAF6 NOX4 IRF3 IRAK4 MYD88 MAP3K7IP1 TAB3 PMC12111645__F7 THC-induced neurotoxicity Via MCU EFHA1 SLC25A23 SLC25A25 MCU PMC8148118__F3 Multifaceted Role of AMPK in Viral Infections TSC2 ULK1 TFEB HDAC7 TXNIP HDAC5 TG FOXO1 HMGCR PMC12006087__F4 KEGG pathway analysis TH ITK BCL10 GRB2 CDK4 TNF ICOS PMC6196273__F2 Iron chelators modulate multiple immunometabolic pathways via the stabilization of HIF1A HIF1A IL1B IFNG PMC10733979__F1 Key cellular metabolic pathways in which NAD(P)H and FAD are involved, including glycolysis, the TCA cycle, oxidative phosphorylation, fatty acid oxidation and synthesis, and the glutathione pathway UCP1 NNT PRX PMC8989428__F3 Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) GPX4 SLC7A11 ATF4 GRB2 SLC3A2 BAX PMC4067916__F1 The Hippo pathway in mammals AREG LATS1 LATS2 FRMD6 PMC5802554__F1 Mutational heterogeneity of angioimmunoblastic T-cell lymphoma indicates distinct lymphomagenic pathways VAV1 ARHA TET2 PMC7577509__F1 Clinical implications of biomarker interactions in CRC PI3 BRAF ERBB2 PMC2529314__F8 Over-representation of Toll-like receptor signaling pathway genes CA14 PMC4527365__F2 Activation and downstream signaling of class III RTKs CSF1R GRB2 FLT3 PMC10967848__F1 Representation of metabolic pathways of lipoprotein PLTP APOC2 LPL LDLR APOC3 ABCA1 MTTP PMC9152215__F4 Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition TH DEK POLL ACAN PMC2529314__F7 Interactions of KEGG pathways for differentially expressed genes in different stages of PAD FER BCR APP PMC5361678__F6 Resveratrol fuels HER2 and ERAlpha-positive breast cancer behaving as proteasome inhibitor RICTOR SRC PTEN MTOR DEPTOR PMC4818883__F2 Frequently mutated genes in ErbB signaling pathway NRG3 BAD BTC FRK SHE HBEGF MTOR NRG4 CRK JUN PMC8516279__F7 Signal and interaction networks of CD36 SLC27A2 ACSS2 PTGER3 LY96 STAB2 MRPL39 HEL-S-104 UMOD C1QTNF7 STAB1 NLRP3 TEFM ZC3H10 LAMB4 TLR4 HPS3 SRC CD14 NR1C1 TNKS2 MAFA APOB DGAT1 PLTP CREBBP CTNND1 TXNIP PPARG CD36 FABP1 PMC4189793__F1 Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione SRC NOX4 PMC2430908__F8 Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity RBPJ PREB TSLP PMC4485330__F1 Regulation of the interleukin (IL)–17 axis is essential for oral immunity and homeostasis STAT1 APC STAT3 PMC8350546__F7 NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells DAZL NANOS2 STRA8 CCND1 ANP32B PTMA RHEB PMC12130335__F9 MAVS’ role in MIRI TRAF5 TRAF6 BCL2 RIGI MAVS BAX PMC5568613__F1 Pathway of corticosteroid synthesis in the adrenal cortex CYP11A1 CYP17A1 CYP11B2 PMC4849781__F2 HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data CMA1 PALM GRAP PMC5124618__F1 Changes in the VE response to inflammatory stimuli during sepsis TFPI MPO PMC6518927__F6 Network of genes targeted by miR-21, based on miRTarBase predictions and analysed by String GID4 SPRY4 MMP9 TGFBR1 SPRY1 PTEN RB1 SMURF1 SPRY2 CBL RECK E2F2 GRB2 TNS1 EZH2 CYFIP1 CASP8 FADD EIF4E3 RMND5A PMC5320444__F5 Comparative physiological and transcriptomic analyses provide integrated insight into osmotic, cold, and salt stress tolerance mechanisms in banana MYB TF PMC7318076__F2 Representative strategies to optimize cytoplasmic signaling of CD28ζ CAR IL2RB STAT3 PMC5678957__F1 Cell biology of APOL1 TFEB APOL1 STAT3 PMC6206573__F8 Ban-Xia-Xie-Xin-Tang on TNF signaling pathway DKFZp666G145 AIP MRPL4 TRADD LIF TRAF3 CASP10 NOD2 CASP3 MAFK TRAF1 JUNB REL TRAF2 FADD ITCH PMC10035756__F5 State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer APC RELA SMO PMC3233626__F5 NIRF interaction network TAF1 TAF1B TBP ING1 CDK2 CDK4 CDC2 HDAC1 PCNA CDK6 PMC8596927__F12 TRPV4-induced Müller cell gliosis and TNFA elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NFKB pathway TRPV4 GFAP STAT3 PMC5587602__F7 Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters IL16 DPP4 IL1B PMC3313666__F7 Outline of the mevalonate pathway RHO CDC42 PMC4822123__F8 Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice NOTCH2 NOBOX BMP15 RAC1 MTOR STAT3 PMC9528772__F8 Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1‐Drp1 signalling pathway ADD1 ROCK1 SIRT6 PMC3726964__F3 Regulation of the EMT Pathway and Tec kinase signaling in Calu-6 compared to U1752 HMGA2 TLR4 GIG8 FOS ZEB2 SMAD4 ARHA FOXC2 SMURF1 PMC4037911__F1 Bid can be activated by multiple proteases in response to a variety of pathophysiological signals MTCH2 FADD BAX PMC8997759__F1 Liquid–Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy TBK1 CGAS NF2 IRF3 PMC5244366__F1 Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway EGF BRAF EGFR PMC305600__F7 An EGF receptor/Ral-GTPase signaling cascade regulates c–Src activity and substrate specificity EGFR SHE SRC STAT3 PMC6975143__F1 Unfolded protein response (UPR).Under normal conditions PERK, IRE1, and ATF6A are sequestered in an inactive state in the ER via their associations with BiP ATF4 EIF2A XBP1 PMC8989153__F1 Heterogeneous Causes of Cushing Syndrome Resulting From Primary Macronodular Adrenal Hyperplasia (PMAH) KDM1A GIPR TRO MC2R HTR7 ARMC5 LHCGR AVPR2 HTR4 PMC9461655__F9 Novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca2+/Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway MMP2 MMP9 MTOR ORAI1 STIM1 PMC4031445__F2 Signal transduction by prostaglandin receptor EP2 EGFR GSK3B SRC PFN1 PMC11907984__F2 Main function of CBXs family proteins CBX1 CBX2 SUV39H1 ME3 CBX6 CBX4 PCGF2 PMC3047603__F3 CYP17 inhibitors for prostate cancer therapy CYP11A1 OMA1 HSD3B2 HSD17B3 RDH5 PMC11907984__F3 Details of CBX members regulate Wnt/Beta-catenin, Hippo, MARK signalling pathways in tumours and mechanism AKR1B10 CBX3 FGFR2 CBX4 BMP4 CBX1 HMGA2 CBX8 CBX2 WTIP PDE4B NCAPG GC CCND1 PMC11907984__F4 Details of CBX members regulate PI3K/AKT/mTOR, NFKB signalling pathways in tumours and mechanism PIK3CD EGFR FGFR3 PTEN S100A9 MTOR IRS1 UBC CBX8 CBX2 PC RNF26 PIK3CA CCND1 PSMC4 EZH2 PMC9224557__F5A Key Immune-Related Genes in the Heart Following Burn Injury CD14 STAC LBP MIP WAS MME POLI PMC11907984__F5 Details of CBX members regulate TGFB, Notch, HFI-1, P53/P21, E2F1/BIRC5, Rho GTPase, PRDM1/c-FOS signalling pathways in tumours and mechanism CBX3 ITGB3 ANGPTL4 YBX1 TGFBR1 EGFR ARHGAP24 VEGFA RHO RAC1 CBX4 HMGA2 UBC CBX8 PC MMP2 HEL25 SMURF2 WDR5 KPNA2 CCND1 HEL113 WNK2 TGFB1 PMC8739678__F3 FcG receptors in HER2-targeted breast cancer therapy TREX1 CAD HTRA2 PMC5667541__F2 Protein O-GlcNAcylation: emerging mechanisms and functions PGM3 OGA OGT CD2 TPR GNPNAT1 SIN3A PMC4882719__F2 Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy EGFR PTEN BAX PMC11354872__F2 Short chain fatty acids (SCFAs) and antioxidant roles against CRC development HEL-S-62p NLRP3 KEAP1 PMC7012898__F1 Upstream and downstream targets of the TOR Complex (TORC) in plants EIF3S3 RPS6 RFWD2 PMC5667541__F4 Protein O-GlcNAcylation: emerging mechanisms and functions ULK1 OGA AgRP OGT KCNQ3 PMC9488999__F1 Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? NLRP3 PINK1 IL1B MAVS PMC6256059__F1 Notch receptor maturation, ligand dependent and independent activation pathway and targetable steps ADAM10 FURIN ADAM17 PMC4558162__F1 OVOL guides the epithelial-hybrid-mesenchymal transition SMAD4 BMP7 STAT3 PMC3772387__F8 Recruitment of FLNa, IQGAP1 and RacGAP1 to active B1 integrin regulates Rac1 activity FLNA IQGAP1 RAC1 PMC4677908__F6 Genomic and transcriptomic features of central carbon metabolism in C PC ASNS HEL107 RPE PMC3461903__F2 New molecular insights into peripheral T cell lymphomas STAT1 PDGFRA PDGFA GRB2 TYK2 JAK1 HRAS STAT3 PMC8228270__F1 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response ISG15 IRF9 TYK2 JAK1 UBE2L6 PMC8228270__F2 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response ISG15 UBE2L6 PMC4821889__F8 Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGFB signalling pathways LATS1 SIAH2 LATS2 PMC5514964__F6 Regulatory functional territory of PLK-1 and their substrates beyond mitosis PLK1 WEE1 BRCA2 RAD51 CDC2 C13orf34 GTSE1 BRCA1 TOPORS MYT1 PMC6769927__F4 The different Transforming Growth Factor B (TGFB) family members on articular cartilage biology and osteoarthritis (OA) development MMP3 ALPL ADAMTS5 RUNX2 SMAD2 PRG4 IL6 SMAD1 DKFZp781O1323 SOX9 STAT3 PMC6769927__F2 Transforming growth factor B (TGFB) family SMAD-dependent signaling GDF5 BMP6 RUNX2 NODAL BMP2 SMAD2 TGFBR2 BMP7 SOX9 SMAD9 BMPR2 ACVR2B ACVR2A SMAD1 TGFB1 DKFZp781O1323 PMC6769927__F3 Transforming growth factor B (TGFB) family SMAD-independent signaling MAPKAPK2 ATF2 GRB2 UNK SP1 MAP3K7IP1 SHC1 CEBPB AK1 PMC3907751__F1 ROS generation and its effect on angiogenesis MPO RAC1 PMC7247360__F1 Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy PI3 RET BRAF PIK3CA PTEN PAX8 PMC3415277__F6 Identification of multiple disrupted components in a biological pathway MUC1 PLCG1 EGF DUSP4 BAD SOS2 EGFR MYC RRAS TG PRKCA MAP2K1 RASSF1 ERBB2 GRB2 CASP9 CCND1 MAPK1 RAF1 TGFA SHC1 PMC2904169__F1 Hypoxia-inducible factor (HIF)-2 regulates erythropoietin (EPO) EPO GATA2 PMC4234705__F2 Eph Receptor Tyrosine Kinases in Cancer Stem Cells EPHA3 MTOR EPHA2 PMC8533163__F8 Bacillus amyloliquefaciens SC06 Induced AKT–FOXO Signaling Pathway-Mediated Autophagy to Alleviate Oxidative Stress in IPEC-J2 Cells ATG12 FOXO3A BCL2 ATG14 DKFZp686F0183 SIRT1 BAX PMC4561380__F6 Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw GHB2 HEL107 PMC4991449__F8 Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment ROR2 IL6 IL6R SFRP5 STAT3 PMC3207123__F1 A view of CD133 expression as it relates to variety of normal tissue and cancer stem cells CXCR4 HIF1A MTOR PMC8486596__F2 Cellular senescence in cancer: from mechanisms to detection ATM CDK2 MYC MDM2 CDK4 CDC2 MTOR ATR CDKN2A CDK6 PMC8479832__F1 Purinergic signaling in the modulation of redox biology MPO PMC9684343__F7 CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor HEL-S-26 PC FASN PMC8479832__F2 Purinergic signaling in the modulation of redox biology CASP3 NLRP3 IL1B PMC12019274__F1 Effect of aberrantly expressed long non-coding RNAs on cell death in different modes NLRP3 AGO2 GPX4 SLC7A11 RIPK3 CDKN2A SIRT1 MLKL GSDMD PMC4324544__F8 Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model BAD FADD PMC8992594__F4 Emerging actionable targets to treat therapy-resistant colorectal cancers IDO1 RELA VEGFA CTLA4 LAG3 PMC9688455__F1 PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints ATM CD80 ATR CHEK1 PMC8992594__F2 Emerging actionable targets to treat therapy-resistant colorectal cancers EGF BAD HGF BRAF ERBB2 ERBB3 EGFR GSK3B CASP9 PTEN EPHA2 TGFA PMC8992594__F3 Emerging actionable targets to treat therapy-resistant colorectal cancers ANGPT2 ACVRL1 BRAF TGFBR2 VEGFA PMC3880999__F1 Molecular details of BAFF/BAFFR-mediated activation of NFKB2 signaling pathway TRAF3 RELB TRAF2 FBXW7 PMC7892976__F2 Se transport across blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCB) GPX4 SELENOP SELENOW HEL-S-134P SELENOF LRP8 PMC7568161__F1 Proposed pathway underlying rh-CSF1 provided neuroprotection PLCG2 CSF1 UCP2 PMC153613__F4 Highlights of key changes in cell cycle, differentiation, and metabolism-related transcripts MAPK9 CDK4 DUSP3 NFATC3 CCND2 BCL6 PMC7469991__F1 Common signaling pathway with miRNAs involved in the different malignant phenotypes of gastric cancer YAP1 SUFU SMAD4 SLC34A2 BMI1 ROBO1 YES1 PTEN POU2F2 STAT3 PMC6035417__F1 Molecular mechanism of apoptosis and necroptosis RIPK1 TRADD RIPK3 MLKL PMC3545927__F6 High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome ALK SMAD2 ATF2 APC GSK3B SMAD4 FURIN SMAD1 DVL1 DKFZp781O1323 GATA4 PMC9563506__F9 PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages PCSK9 CD163 MMP9 CXCL9 CDH2 ARG1 IL1B PMC6953059__F1 Steps involved in the biogenesis and functions of miRNAs DGCR8 RAN PMC6799833__F7 Potential mechanisms of fluoxetine in the remission of AD APP SIN3A BDNF HDAC1 PMC9664042__F1 Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1B IL33 IL1B GSDMD PMC7614756__F6 Effect of NRP1 on the TGFBR2-VE-cadherin pathway in regulating adherens junctions and inflammatory responses CXCL1 CSF3 TGFBR2 IL11 CXCL2 CCL5 IL6 CCL2 IL12A HMOX1 SELL CXCL16 IL16 NRP1 CRP SELP CXCL12 CSF1 TGFB1 SIRT1 CXCL11 PMC6337329__F6 Proposed model of molecular interactions and clustering analysis ROCK1 HEL-S-28 ARHA MTOR PARVA RSU1 CDC42 PMC4631757__F10 The interaction between corneal stroma (canonical Wnt signaling) and epithelium (Bmp4 signaling) during mouse corneal development TEF LRP5 LRP6 SMAD1 DKFZp781O1323 BMP4 PMC5496044__F1 Schematic diagram of domain structure for LRP1 and LDLR EGF LDLR FURIN PMC6799833__F4 Autophagy pathway ULK1 ATG16L1 TSC1 ATG12 ATG3 AMBRA1 UVRAG ATG14 DKFZp686F0183 VMP1 RHEB PMC9523483__F2 OncomiRs as noncoding RNAs having functions in cancer: Their role in immune suppression and clinical implications MICB MICA TNF PMC5514916__F8 NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway ACVR1 MDM2 SMAD4 PMC4071053__F2 Molecular network generated by Ingenuity Pathway Analysis (IPA) of highly significant gene changes in human RPE cells after in vitro stimulation with AGE (10 μg/mL) IFIT3 IFIT2 RSAD2 EIF2AK2 CCL5 MX2 PNPT1 USP18 IFNG DTX3L STAT1 SP110 XAF1 ANGPTL1 IFIH1 CXCL11 IFIT1 PMC4071053__F3 Interferon Signaling Pathway identified by Ingenuity software STAT1 IFIT3 STAT2 IRF9 PIAS1 IFI35 IRF-1 PSMB8 IFNG BAX PMC10483736__F1 Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA) CTC1 STN1 TEN1 TPP1 TERT PMC12017889__F1 Reported regulatory mechanisms of ferroptosis GPX4 LPCAT3 STEAP3 FACL4 FTH1 SLC7A11 FTL LPO MTOR PMC6390333__F1 De novo biosynthesis of various aromatic compounds derived from the SHK and aromatic amino acid biosynthesis pathway TH PTS CS DDC STS FH SMO PAH PMC12017889__F3 Relationship between ferroptosis and immunity STAT1 HMGB1 SLC7A11 IFNG PMC8555666__F10 Differential Association of Free, Conjugated, and Bound Forms of Polyamines and Transcript Abundance of Their Biosynthetic and Catabolic Genes During Drought/Salinity Stress in Tomato (Solanum lycopersicum L.) Leaves ARG2 SOST PMC5342554__F8 NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma APC GRB2 NTS RHO PMC6271612__F1 The molecular mechanism behind mitophagy after stroke MFN1 MFN2 BNIP3 PMC3976614__F1 Modulation of mitochondrial dysfunction by the PINK1/PARKIN pathway PINK1 MFN2 PMC8545469__F7 T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese TBK1 CGAS IRF3 PMC6571408__F9 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MAGE A11 in patients with esophageal squamous cell carcinoma (ESCC) TNF MTOR PMC3676391__F1 Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling ADIPOR1 OSM APPL1 PMC6796858__F10 Cortical branched actin controls the G1/S transition HEL-68 ARPIN CORO1B ARPC1B PMC7464279__F7 Synergistic effect of cyclopamine and rapamycin SUFU GLI3 SMO PMC8234594__F1 Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review FOXA1 TRAF1 GSK3B TRAF3 CCND1 TNF TRAF2 PMC8728363__F6 Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer CCR5 CD47 CCR2 CD40 CD24 PMC7226088__F2 Regulatory signaling pathways in MDSC development and functions STAT1 COX2 IL16 S100A8 CCND1 RIPK3 IL6 MYD88 JAK1 ARG1 STAT3 PMC9374671__F1 Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2 NNMT PARP1 CYP2E1 SIRT1 NRK PMC3359728__F3 Regulation of homeostatic AMPAR trafficking and turnover ARC CDH2 BDNF PMC1383482__F1 Tumor Necrosis Factor by Microbial Pathogens TRADD TNF FADD BAX PMC8249562__F4 Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease PINK1 EBP GZMM CDH2 HSF1 PHB2 STAT3 BAX PMC8816937__F7 Schematic diagram showing that the ETV4 functions in HCC metastasis MMP7 MYC ETV4 DVL2 PMC6477167__F1 Interplay between HPV-infected keratinocytes and the local immune microenvironment critically influences cervical carcinogenesis.HPV suppresses inflammatory signaling in the host keratinocyte IL18 CCL20 CCR7 CCL2 IL1B PMC7734179__F1 Cytosolic DNA sensing pathways TLR9 TRAF6 MYD88 MTOR AIM2 GSDMD PMC4662454__F4 Targeting cancer by binding iron: Dissecting cellular signaling pathways SMAD2 ATF2 GRB2 SMAD4 SRC STAT3 BAX PMC4662454__F5 Targeting cancer by binding iron: Dissecting cellular signaling pathways SMAD2 APC GSK3B SMAD4 LRP6 ARHA CDH2 PMC3378977__F1 Summary of the suggested mechanism for the regulation of MMPs and TIMPs in the paracrine interplay between SCC-25 cells and fibroblasts TIMP3 CD44 PMC4220839__F2 Cytosolic DNA recognition pathway for IL-1B production CARD9 RAD50 AIM2 IL1B PMC9170611__F4 Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer TSC2 RICTOR TSC1 LRP5 LRP6 PTEN PMC9292562__F3 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing NAMPT TRPM2 IL1B FOXP3 PMC7460532__F1 Phosphatase and tensin homolog (PTEN) signaling pathway and its interactions PTEN MTOR PMC9292562__F4 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing NAMPT TPH1 AHR SIRT1 PMC9292562__F2 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing NAPRT NAMPT VIT HEL-S-90n SARM1 NRK PMC10779434__F2 The actin cytoskeleton within the foot processes IQGAP1 TRPC6 ARHA RAC1 ACTN4 CD2AP SSH1 CDC42 PMC7554583__F1 Mitochondrial stress responses in cystic fibrosis PINK1 BCL2 ATF5 PAF1 CLPP BAX PMC7554583__F2 mtDAMPs in cystic fibrosis Under stress, mitochondria generate and/or release immunogenic molecules, named mitochondrial damage associated molecular patters (mtDAMPs), that influence significantly the inflammatory response in CF lung disease NLRP3 VAPB NLRC4 MCU ATF5 PMC3743096__F4 Signal integration by mTORC1 coordinates nutrient input with biosynthetic output RUVBL2 RUVBL1 ATF4 EIF2A VHL RHEB PMC2938197__F1 Predicted hydroxy/hydroperoxy wybutosine biosynthesis pathway and domain architecture of key enzymes involved in its synthesis TYW3 TYW1 PMC5707548__F1 ATM (ataxia telangiectasia mutated)-mediated DDR (DNA damage response) signaling pathway RNF168 RNF8 ATM MDC1 H2AX BRCA1 PMC5535871__F5 Functional overview of ANRIL and pathways PRC1 ATM IL6 PMC4698399__F8 Processes responsible for the synthesis, trafficking, and degradation of membrane proteins DENND4C M6PR EHD1 LAMP2 EGFR EEA1 EHD2 CASK EHD3 RAB17 RAB7B RAB7A RAB10 PMC8286837__F1 Hypoxia activated UPR and DDR pathways ATM ATF4 EIF2A MTOR ATR XBP1 PMC4384293__F2 Paradoxical roles of autophagy induced by the tumor microenvironment during different stages of tumor development TSC2 FOXO3A ATF4 EIF2A BNIP3L BNIP3 PMC4548922__F2 Decreased fatty acid oxidation contributes to CKD progression TGFB1 CD36 PMC11763227__F7 FGF19 working model CYP8B1 FGF19 FGFR4 CYP7A1 PMC4986275__F4 Representation of the top Canonical Pathways, Functional Annotations and Upstream Regulators detected upon analysis of target genes and their co-regulated genes CCR5 MHC2TA ACTA2 EGFR CCL5 CSF2RB IFNG TLR8 LCP2 IL10RA PSMB9 IL10 IL13 TNF DKFZp686L24211 C3AR1 TNLG7A ID3 TLR3 HLA-DOA GNG12 IL15 PTPRC HLA-DPB1 GIG8 TIMP1 IGFBP4 TGFB1 STAT3 PMC8197124__F2 Crossroads between Host Copper Metabolism and Influenza Infection SLC25A3 ATP7B COX17 ATP7A ATOX1 CCS PMC5983675__F2 Tumor necrosis factor receptor signaling in multiple sclerosis PDGFRA LIF CXCL12 TNF IFNG PMC5963198__F4 Model of miR155 activation in BMDMs exposed to C SRC SYK PMC11621778__F9 Multi-omics co-analysis ADORA2B ADAM8 RAB38 SEMA7A HEPACAM P2RX7 SMAD2 PPP2R2C TRIB3 SNAI2 SPHK2 VIP USP18 FAT10 IRF7 COL27A1 HAS1 TRH SPHK1 TGFB1 CD36 HEL-S-62p EEF2K DHX58 PCK1 COL1A1 ZBP1 ISG15 COL1A2 NCOA1 CAD MKX IRGM BMP7 IL6 NMBR CREBBP GABRB1 SLC27A1 ADRA1D SPTLC2 WDR37 NPFF ADRA2B GBP4 LAX1 SMAD1 COL4A2 COL4A1 STAT3 PMC2806892__F1 Methionine metabolism in vivo HEL-S-61p PMC11763227__F4 FGF19 alleviates LPS-induced hepatocytes apoptosis associated with AMPK activation in vivo and in vitro FOS FGF19 PMC5516800__F3 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? PSAT1 SHMT1 MTHFD1 PHGDH PMC5516800__F1 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? ALDOB F2 PFKFB2 PFKFB1 GCK PFKFB4 HEL-S-87p HEL-S-133P HK2 HEL-S-281 HEL-S-68p HEL-S-162eP PMC3055447__F4 A schematic diagram of pyramidal cells (triangular) and GABAergic interneurons (square) within the trisynaptic pathway of the hippocampus GCA HEL-S-11 PNN PMC5516800__F2 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? HK2 PMC5516800__F5 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? ALDOB BRAF MYC PFKFB4 HEL-S-87p HEL-S-68p HEL-S-162eP F2 SRC PGAM1 HEL-S-133P HK2 HEL-S-281 PMC5516800__F6 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? ALDOB F2 FBP1 PFKFB2 PFKFB1 PFKFB4 HEL-S-87p HEL-S-133P HK2 HEL-S-281 PMC4513218__F1 Part of the tamoxifen metabolic pathway CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC8468752__F2 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia CYP3A4 ABCG8 ABCG5 ABCG2 ABCB11 ABCB1 UGT1A1 PMC4279797__F1 Pharmacology network-based drug repurposing for CMT1A disease IGF1 EGR2 FLNA SRC BCL2 GAL PENK PMP22 TRPV1 PDYN PMC8032975__F2 Lipoproteins and their three different metabolic pathways PLTP APOC2 LPL HEL-S-70p MTTP APOE PMC8468752__F1 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia ANGPTL3 PCSK9 ABCG5 LPL ABCG2 APOE HMGCR PMC7180987__F1 Effects of growth hormone on adipose tissue: old observations, new mechanisms G0S2 PLIN1 GHR TG PMC7989705__F2 Solute carriers (SLCs) associated with PDAC cell proliferation, angiogenesis, invasion, and metastasis TP53INP1 SLC7A11 CD44 IL6 SLC3A2 MTOR LATS2 STAT3 PMC7920467__F1 Ceramide de novo synthesis pathway CERS3 LASS1 CERS5 PMC3944264__F6 Proposed model for miR-542-3p-mediated suppression of osteoblast proliferation and differentiation RUNX2 BMP7 SMAD1 DKFZp781O1323 PMC7923474__F4 Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E MCM3 EIF2S1 SMC1A LMNB2 SKP1 ITGB1 HEL-S-93 PMC7884645__F2 NLR in eXile: Emerging roles of NLRX1 in immunity and human disease TUFM CGAS ATG16L1 ATG12 IRF7 NLRX1 TRAF3 TRAF6 IRF3 DKFZp686F0183 MAVS PMC7989705__F3 Solute carrier (SLC) expression is associated with cell death GPX4 HEL-S-298 SLC7A11 SLC3A2 SLC31A1 PAF1 PMC2612524__F7 A potential model for contributions of F-BAR-containing adaptor proteins and PTKs in regulating FcɛRI signaling during internalization FER LYN FES SYK PMC4872729__F2 Understanding the role of the kynurenine pathway in human breast cancer immunobiology HEL-S-90n GIG8 KYNU KMO ID1 TDO2 PMC6274245__F5 Upstream signal transduction pathway leading to activation of canonical p50/p65 NFKB upon stimulation by tumor necrosis factor (TNF)A (see text for details, scheme realized with ScienceSlides) TRADD TNF MAP3K7IP1 TRAF2 PMC6274245__F6 Regulation of posttranscriptional modifications of NFKB and histone H3 with and without TNFA stimulation SETD6 HDAC2 HDAC1 SIRT1 PMC3226194__F7 An integrated pathway model involving FOXA1 in breast cancer ATM FOXA1 BRCA2 CYP2C18 EPHX2 RAD51 BRCA1 PMC5976735__F3 Main signaling pathways involved for 12 miRNAs differentially expressed after exercise from EVs purified from rat’s serum POR LAT PMC6738443__F4 Modular network regulation map of gene-related ncRNA/TFs WAS IL6 MIP FUS NR1C1 ADAM17 CPT1A ATF4 TNFSF14 RELA MIA LDLR APP ACSL1 CD40 MIIP REST TUG1 MME TF ELL BAX PMC10889827__F3 Ihh signaling plays a critical role in periosteal bone biology and shows complex interaction with other molecules IHH BMP2 SUFU SMO SMAD1 DKFZp781O1323 PMC10889827__F4 Wnt signaling has important indirect as well as direct effects on PDCs IHH BMP2 APC GSK3B SMAD1 WNT7B DKFZp781O1323 PMC10889827__F1 BMP signaling represents a fundamental signaling profile in periosteal effects BMP6 WNT3A BMP2 PTH BMP4 PMC10889827__F2 PDGF signaling mediates periosteal activation and blocks BMP2-induced osteogenesis BMP2 SMAD1 DKFZp781O1323 PMC8005457__F7 Pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells BCL2 PARP1 BAX PMC6203329__F2 Cellular oxidative and genotoxic stress responses converge on the AMPK/mTORC1 pathway TSC2 TSC1 ATM RHEB PMC7408280__F3 Transcriptional modulation of the inflammatory response in PD MAF TH COX2 IL6 IL1B PMC9636152__F1 DNA damage signaling pathway RNF168 RNF8 RIF1 ATM MDC1 BARD1 H2AX BRCA1 PMC4253418__F7 Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer WNT3 APC GSK3B CCNB1 CCND1 SRC RYK MTOR TF PMC5059721__F6 Carbon Ion-Irradiated Hepatoma Cells Exhibit Coupling Interplay between Apoptotic Signaling and Morphological and Mechanical Remodeling DIABLO BAX PMC6539048__F5 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study KLF10 SMAD4 CCND2 INSR FST TACR3 HEL-S-112 BTG2 TGFBR3 PHIP ECE1 CHRDL1 HSPA4 IHH EGR1 MAP3K1 ANGPTL4 FOS IGFBP7 VEGFA UBE2B ID1 EDNRA MMP14 GIG8 EGR2 TXNIP MCL1 VCP PMC6539048__F6 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study EGR1 IHH FOS KLF10 VEGFA IGFBP7 SMAD4 ID1 INSR MMP14 GIG8 EGR2 BTG2 PMC9530954__F12 Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data CPM VPS35 ATP6V0B PHF10 MAPK9 METRN TAF10 SYN2 MYLIP SALL1 RPL35 ANKRD40 TRIM8 RPL18 AHNAK BRD7 FGF12 ATP6V1C1 RAB6B PRELP HINT1 RBM17 PMC5616168__F13 Schematic diagram for the ADTRP signaling pathway APOB CAD PIK3R3 ADTRP PMC6600571__F1 Skeletal muscle insulin signalling MTOR IRS1 PMC6478619__F1 Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif is a point of convergence in signaling pathways RICTOR IGF1 BIRC5 AREG CXCL5 EGFR LATS1 RHO LATS2 IRS1 PMC9013714__F7 Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway EGFR TNF IL1B PMC8080681__F2 Aberrant HNF4Alpha-related cell signaling pathways in cancer HNF4A SMAD2 GSK3B IL1R1 TCF4 STAT3 PMC6760925__F5 Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations ASMT OGT GAA AANAT MTNR1B PMC554120__F8 The inhibition of Myt1 in the meiotic and mitotic cell cycles in Xenopus MOS MYT1 PMC7072214__F5 Phosphatidylinositol 3-kinase (PI3K) signaling pathway and signaling outputs BAD CCND1 BCL2 CDK4 SGK1 CDK6 PMC7072214__F4 Apoptotic signaling pathways with the reported interaction of Rab proteins BCL2 FADD BAX PMC3742358__F3 Pathway of nucleotide excision repair and translesion synthesis XAB2 XPA PCNA UVSSA PMC5342378__F8 PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer ZIC1 CCND1 GADD45A CDK4 CDH2 PAX3 CDK6 PMC12012940__F1 Identification and characterization of the core HPARBP network DYNC1H1 EIF5B CPSF6 NCBP2 NPM1 TRMT1 GTPBP4 RCL1 PRPF3 SNRPG EEF1E1 SNRPA EWSR1 ILF3 RUVBL1 PTBP1 SSB POLDIP3 DNCL1 KHDRBS1 TCERG1 DDX42 YARS2 FXR1 FIP1L1 SNRPD1 RBMX U2AF2 RPS3 RAN DENR SNRPB2 UBAP2L RBM12 PMC2582888__F8 Two parallel pathways are required for Abl-dependent cell detachment ROCK1 ARHA LPA EPHA2 CRKL PMC7206374__F4 Potential regulatory modeling of miR126-3p and PIK3R2 in porcine GCs (pGCs) INSR PIK3R2 PMC8144021__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction IL33 IL25 TSLP PMC5613059__F1 Frequent genetic alterations of PI3K/mTOR signaling pathway in HNSCC TSC2 PIK3CD RICTOR TSC1 PRKAA2 EGFR PRKAA1 PIK3CA PTEN EIF4E EIF4EBP1 RHEB PMC12012940__F7 The underlying molecular mechanisms of the specific HPARBPs and their common binding targets regulating the Wnt signaling pathway ZNRF3 RNF43 NCBP2 PTBP1 LRP5 LRP6 ILF3 U2AF2 GPR49 PMC8719641__F3 New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris PTS PMC5874430__F10 Ingenuity Pathway Analysis (IPA) diagram of the cell cycle control pathway MAX SUV39H1 CDK2 MDM2 SMAD4 NRG1 BMI1 SIN3A ATR PAK1IP1 PMC5649056__F3 Canonical Wnt signaling and bone remodeling LRP5 LRP6 PMC7072285__F6 Putative inhibitory effect of 8-HD in the IRF-3 signaling pathway TBK1 TLR4 CXCL10 TRAF3 IRF3 MYD88 TIRAP IFIT1 PMC8501049__F10 CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling MFN2 MCU RYR2 PMC2928711__F9 Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFKB/HIF-1A activation SP1 STAT3 PMC8938628__F1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway APC GSK3B LRP5 LRP6 BCL9 PMC8537064__F1 Molecular Mechanisms of the SLC13A5 Gene Transcription CIC ACLY MTOR SLC13A5 PMC5355165__F1 Crosstalk between microRNAs and the Wnt/Beta-catenin signaling pathway in cancer RUNX3 APC IGF2 CCND1 BCL9 PMC4233297__F2 Summary of myocardial cellular effects and the injury response induced by anthracyclines CASP3 TLR4 NFAT5 BRCA2 MTOR GATA4 BAX PMC5828413__F3 PPI network of CAD genes ALK PPP2R2C DAP HIF1A GOSR2 CTIF SMARCA4 MAP4 MIA MSRA FIGN CSK FES HFE HNF1A ATXN2 HEL-S-15 PCSK2 RPTOR TXNDC11 TET1 MIA3 ADARB2 SYNE1 PTPRG TUBA1C IMMP2L ARHGAP42 GNG2 PLCE1 MACROD2 TNS3 KPNA3 MAGI1 DIPLA1 CYP17A1 NFIA ARL15 RBM19 NAV2 PNLIPRP3 NALCN RASD2 DISC1 DNAJC5B WDR12 HS3ST2 MYO1D CYP24A1 RNF103 NLRP11 NMT1 TLL1 ZNF610 ZNF652 EVI1 PMC4490154__F1 What do we know about the cardiac benefits of exercise? CITED4 SET IGF1 NRG1 PTEN PMC5513686__F1 Principal effects of chronic alcohol abuse on anabolic and catabolic mechanisms that maintain skeletal muscle mass IGF1 MTOR IRS1 PMC8401259__F5 Immune Response and Apoptosis-Related Pathways Induced by Aeromonas schubertii Infection of Hybrid Snakehead (Channa maculata♀ × Channa argus♂) CASP6 BAD CASP12 TRADD FES MYD88 TNF CASP3 ATM CASP9 TRAF2 FADD BAX PMC3069685__F2 An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy PAK1 CREB3L2 FRS2 ATF5 MCL1 PMC8401694__F1 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies RUNX2 BMP2 TNFAIP3 SMAD1 TRPM7 GPR39 PMC8401694__F2 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies RUNX2 BMP2 ENPP2 GPR39 PMC5828413__F2 Coexpression network of CAD genes and metabolic pathway genes GAD2 GGH GLB1 PPP2R2C DAP CA3 PYGM ACSL6 POLE2 MAP4 ADSL NMNAT2 PAICS RPE PGAM2 ENO3 FBP2 ADCY1 AGPAT4 DHFR UMPS MYH7 CYP21A2 PCSK2 RRM1 RRM2 PLCE1 HSD3B2 HEL-S-70p CYP17A1 PNLIPRP3 NALCN RASD2 WDR12 HS3ST2 CYP24A1 DGKB NUDT5 COX6A2 HS6ST3 NMRK2 NDST3 C5orf47 SEZ6L ITPKA TYMS PAPPA2 PDXP CKMT2 FUT9 MGAT2 DDOST SYT2 SCD5 PMC6113562__F3 Regulation of inflammatory arachidonic acid (AA) derivatives after Leishmania infantum or Leishmania donovani infections NAT2 PMC4571721__F5 Chemokine signaling pathway map created based on KEGG pathways ITK GRB2 SHE ARHA JAK3 CRK PMC2810291__F6 Endonuclein functions SSB ARHA STAT3 PMC8560782__F1 Urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response SMUG1 MBD4 TDG UNG PMC7685174__F1 Balance of angiotensin (Ang) II and Ang-(1–7) in the renin-angiotensin system (RAS) TOMT ACE2 PMC2861953__F2 Altered signaling pathways and mouse models of thyroid cancer RET TSHR NTRK1 PTEN PMC4967202__F2 MMP-9 signaling in the left ventricle following myocardial infarction CCR2 IL16 PLG SP1 IL1B CD36 PMC8131382__F7 Hypothetical model for the regulation of cell proliferation and tumorigenesis by the Notch3ICD/PTEN axis PTEN MTOR NOTCH3 PMC6743293__F2 Molecular mechanisms of KLF15 in renal fibrosis and mesangial pathology KLF15 CDK2 PMC8569436__F1 STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications MYC HIF1A GAA STAT3 PMC8214965__F5 姜黄素通过Wnt/Beta-catenin信号通路诱导人晶状体上皮细胞的凋亡和细胞周期阻滞 APC CCNB1 CDC2 MAL PMC12043473__F2 Conversion from normal fibroblasts (NFs) to cancer-associated fibroblasts (CAFs) involves multiple molecular mechanisms EREG YAP1 SMAD2 IL33 CD44 SMAD4 LPA SKI SOCS1 IGF2R STAT3 PMC12043473__F3 Origin of CAFs are complex, diverse, and heterogeneous MSC CXCL12 STAT3 PMC7176765__F1 Multiple Lysine methylation regulate cellular functions of p53 PRMT1 SETD7 SMYD2 USP28 GIP PMC4540601__F4 Differences in M1- versus M2-macrophage fueling reactions CPT1A ARG1 CD36 PMC2997522__F2 Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies CXCR4 SMO PMC5967272__F1 Aberrant signaling in systemic lupus erythematosus (SLE) T cells LCK CD44 SYK PTEN IRF4 STAT3 PMC8566527__F6 The mechanism of CIRT boosts anti-tumour immune responses in melanoma-bearing mice ARG1 STAT3 PMC3945331__F4 Modules identified by functional and gene expression enrichment analysis MYH9 PRKCZ AP2A2 SOST ARHGEF12 GSK3B MYC NAPB EZR STX1A DNAJB1 DES WAS RHO FLNB NACA MYH10 UBB RDX RPSA PFN1 MYH1 DLG4 UBE2S HTT HEL114 SP1 RAPGEF2 SNCA ARHGEF1 ARHGEF7 FOS HEL-S-28 BAIAP2 GFAP APC PIK3R3 CREBBP EP300 TCERG1 NFKB2 WASL PRMT2 HEL113 GNAS GNB1 MYLK PIK3R2 PMC3945331__F5 Additional functional modules identified by ingenuity pathway analysis CLTA HIPK2 SOST MAPK14 DNAJB1 PTEN HSPD1 MTOR UBB TXN BAG1 INSR TSG101 PSMD7 RPS18 FYN DNAJC21 SYMPK AP2M1 HTT HGS MDM2 AMPH HEL114 B2M EIF4B ARHGEF7 FOS APC FTL RBX1 DVL1 APOB ITGB4 CREBBP EP300 MAX DNAJB11 WASL ZYX RASGRF1 MYLK PIK3R2 AKT3 PMC9102675__F2 Endothelin and RAS/ERK signaling in immunopathogenesis-related fibrosis in patients with systemic sclerosis: an updated review with therapeutic implications HRAS MTOR PMC5727330__F1 Downstream effectors of Ras pathway including Ral pathway and their biological roles RIN1 RHO CDC42 PMC5727330__F2 RalA/B effectors RALA CCND1 ARHA RAC1 RALBP1 CDC42 PMC2975924__F3 Eph/ephrin signaling regulates intestinal cell positioning and proliferation DAAM1 PI3 DVL2 PMC5501892__F2 Metabolic profiling of intracellular glycometabolism CS MYC ENO1 IRS1 HEL60 HEL-S-32 RHEB HEL-S-68p HEL-S-162eP TSC2 HEL-S-26 FH PDHA1 HEL-S-304 RPIA OGDH SUCLG2 HEL107 SDHA PMC5501892__F4 mRNA expression of enzymes and factors involved in glycometabolism CS MYC PRKAA1 PFKM HIF1A HEL-S-32 HEL-S-26 FH PDHA1 HEL-S-304 RPIA OGDH SUCLG2 PRKAG1 PRKAG3 HEL-S-133P PRKAB2 SDHA PRKAB1 PRKAA2 HEL-S-30 ENO1 HEL-S-87p IRS1 HEL60 RHEB HEL-S-162eP HEL-S-68p TSC2 HEL-S-49 RPS6KB1 TSC1 PRKAG2 HEL107 PMC4489427__F6 Integrated analysis of alterations in key pathways in nccRCC subtypes PDHA2 PRCC SDHC FLCN VHL PTEN HIF1A RHEB TSC2 TSC1 TFEB FH PDHX SDHD SDHB PMC5661624__F3 Redox regulation of cell–cell junctions RELA PMC6320606__F3 Schematic model depicting the proposed signaling pathway in LH/hCG-induced the resumption of meiosis EGF NPR2 WEE1 EGFR BMP15 NPPC FSHR COMP MYT1 PMC6941304__F1 Models of Siglec-15–ligand interaction and downstream signaling CD44 TRAF6 SYK PMC4366058__F4 Mirin is an antiviral polyamide (AVP) sensitizer ATM RAD50 MRE11A PMC7160537__F7 Mechanism of TP-induced lung cancer cell inhibition via ribosomal stress initiation NCL MDM2 RPL23 PMC5661624__F4 Redox regulation of cell mobility GSK3B MDM2 SRC ARHA PTEN RAC1 CDC42 PMC6190877__F1 General schematic diagram of molecular players involved in sex differentiation of gonochoristic teleost with genetic sex determination AMH DMRT1 FOXI2 FOXL2 SOX9 PMC6365663__F2 Overview of the heme biosynthetic pathway SLC25A38 SLC25A37 SLC25A28 PMC9693741__F2 Advances in neovascularization after diabetic ischemia VHL ROBO1 SLIT2 PMC7810547__F2 miR-155 modulates TLR4 signaling pathway in sepsis TLR4 IRAK1 TRAF6 MYD88 SOCS1 PMC5458543__F3 Fucose metabolism pathways and variation in types of fucosylated glycans EGF SLC35C1 FUT1 FUT4 FUT6 POFUT4 FUT5 hCG_1998026 POFUT2 FUT7 FUT3 POFUT3 POFUT1 FUT8 FUT9 PMC2727282__F7 Proposed coloboma mechanism in Lrp6-null eyes and a possible signaling network during early eye development VAX2 TBX5 LRP6 BMP4 PMC7756118__F6 The signaling pathway involving in megakaryocytic differentiation in normal and leukemic marrow NPM1 AXL PMC8238072__F1 Experimental Drugs for Chemotherapy- and Cancer-Related Anemia SMAD2 IL6 STAT3 PMC4777597__F1 The 5S RNP complex (RPL5, RPL11 and 5S rRNA) regulates MDM2-p53 in response to cellular stress RPL11 MDM2 RPL5 PMC7674854__F1 Schematic overview of insulin signaling and glucose utilization pathways in the brain MTOR IRS1 PMC7396595__F2 In the absence of co-stimulation, typically in a T lymphocyte that has not been exposed to antigen yet (naive T cell), GSK3B is constitutively active and phosphorylates NFAT2 IL10 TBX21 GSK3B IL2 CD80 FOXP3 PMC12025042__F4 Non-genomic actions of Vitamin D STAT2 CYP24A1 CYP11A1 STAT1 CANX NR1i1 PLAA CYP2R1 CUBN HEL-S-269 DBP SRC STAT3 PMC6235178__F1 Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor LATS1 LATS2 PMC8012837__F1 Trop2 signaling NUMB PARP1 PMC3633488__F3 Decorin’s effects on Beta-catenin and Myc stabilization by directly down-regulating EGFR and Met EGF CIP2A MYC LRP5 LRP6 PMC3707615__F5 Encoding and Decoding Cellular Information through Signaling Dynamics EGF TLR4 NGF ATM NGFR EGFR MDM2 ATF3 ATR PMC4322839__F1 Negative feedback loops at the core of transcriptional oscillators MDM2 HES1 PMC8466058__F1 Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation NOTCH1 ADAM10 HES1 PMC7794676__F5 Pyroptosis on the tumor microenvironment CASP3 GZMA GSDMC CASP8 GSDMB DFNA5 PMC8833582__F5 Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges SMAD2 SMURF2 TGFBR1 SMAD4 TRAF6 STAT3 PMC5405080__F11 Reactive oxygen species (ROS) maintenance by redox homeostasis TIGAR ATM PMC6721595__F1 Human oligodendrocyte precursor cells (hOPCs) incorporate and metabolize nervonic acid MOG FIG4 MBP PMC3230307__F1 Autophagy regulation TSC2 TSC1 PTEN MTOR RHEB MLST8 PMC5535015__F1 NPD1 inhibits apoptosis during UOS TRADD BIRC3 TRAF2 FADD PMC9184412__F2 Dopaminergic control of Cushing’s syndrome EGR1 DAO GAL MTOR PMC3928023__F3 Wiring and firing neuronal networks: Endocannabinoids take center stage NAPEPLD DAGLB DAGLA ARHA CDC42 PMC5381981__F1 Metabolic scheme of targeted oxylipins LTA LTB PMC10779100__F1 Regulation of osteoclast formation by MERTK and TYRO3 PROS1 TYRO3 ARHA MERTK PMC10779100__F2 TAM receptors and their downstream signaling pathways in osteoblasts IGF1R PROS1 IGF1 APC GSK3B TYRO3 ARHA MERTK DKK1 AXL IRS1 VAV2 PMC3720736__F2 Activation of Wnt/Beta-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients APC LRP5 LRP6 PMC6736563__F1 DSB repair pathways RAD51 PARP1 PMC5535015__F2 Up-regulation of BIRC3 transcription by NPD1-dependent c-REL expression TBK1 TRADD BIRC3 TRAF3 TRAF2 PMC9278165__F6 Comparative Transcriptome and Metabolome Analysis of Resistant and Susceptible Piper Species Upon Infection by the Oomycete Phytophthora Capsici CAD CERK PMC10758851__F1 Development and Clinical Applications of PI3K/AKT/mTOR Pathway Inhibitors as a Therapeutic Option for Leukemias TSC2 TTI1 RICTOR CHUK TSC1 BCR MDM2 PTEN DEPTOR RHEB MLST8 PMC10137778__F8 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth HRC CASQ2 RYR2 PMC10137778__F9 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth RET TUB PMC6633870__F7 Genes were clustered in the PPI network according to string database (genes from top 10 predicted pathways in BQG-treated group versus BLM group) MAP2 NCK2 RPRM FES PAK4 RARA MAPK13 CDKN2B GRB2 NOTCH1 MAP3K14 SESN2 STH RASAL1 NCOR2 RGL2 FZD8 BAX BOK PMC7543578__F2 Sites of action of novel treatments for Graves hyperthyroidism IGF1R TSHR CD40 IL6 PMC9406657__F2 PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer TSC2 MDM2 PTEN FOXO1 PMC3372214__F1 Simplified schematic presentation of HCV genotype 2a-mediated blocking of the insulin signaling pathway TSC2 IRS1 RHEB PMC4100379__F5 The proposed mechanism underlying the inhibitory effect of MLN4924 in prostate cancer cells WEE1 ORC1L CDT1 PMC3118679__F1 The networks of factors (genes product, hormones, and metabolites) potentially involved in the regulation of milk protein synthesis in lactating bovine mammary tissue CSN3 ELF2 LARS2 EEF2K ELF5 LALBA EEF2 EIF4E MTOR STAT5B IRS1 RHEB INSR ELF3 RPS6 PMC3118679__F7 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 60 relative to −15 d postpartum CSN3 LARS2 EEF2K LALBA SLC1A1 RPL22 EEF2 MAPK14 GSK3A RPL4 EIF4E RHEB INSR TSC2 RS1 TSC1 ELF3 RPL23 RPS6 ELL PMC3118679__F8 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 240 relative to −15 d postpartum CSN3 LARS2 EEF2K LALBA RPL22 EEF2 MAPK14 RPL4 EIF4E RHEB TSC2 RS1 TSC1 RPS6 PMC5584741__F1 Regulation of autophagy signaling pathway ATG12 ATG3 VPS16 AMBRA1 UVRAG ATG10 MTOR ATG14 DKFZp686F0183 PMC3118679__F6 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 15 relative to −15 d postpartum LARS2 EEF2K LALBA RPL22 EBP EEF2 MAPK14 RPL4 EIF4E MTOR RHEB INSR TSC2 RS1 TSC1 ELF3 RPL23 RPS6 PMC3952558__F2 TLR4 Signaling Pathway CD14 TLR4 IRF3 MYD88 TIRAP PMC3337621__F2 Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation PI3 CD2 IL6 PTEN MYD88 MAL FOXP3 PMC9487140__F1 Review of potential medical treatments for middle ear cholesteatoma HMGB1 BTK TLR4 CYLD ID1 IL6R PMC3633528__F1 Cytokine signaling cascades that influence tropoelastin transcription EGF EBP CDK2 HBEGF CDK4 SP1 TGFA JUN TGFB1 PMC6700477__F1 SHH pathway activity leading to phenotypical changes in esophageal epithelial cells PTCH1 SHH SMO SOX9 BMP4 PMC8844485__F3 Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting HMGB1 BCR ATM PARP10 RELA PARP1 IL1B PMC8617206__F4 JAK/STAT signaling pathway: from bench to clinic STAT1 STAT2 IRF9 SMAD1 STAT3 PMC6083010__F3 Ingenuity Pathway Analysis of Molecular Activation Based on Gene Expression Profiles(A) Gene expression data were analyzed by Ingenuity Pathway Analysis IKBKG CHUK TLR9 DOCK8 F2RL1 SAMSN1 IFNL1 EIF2AK2 IFNL4 MYD88 HIF1A TNK1 SYVN1 FZD9 IFNG STAT1 TLR7 TLR4 MSC APP IFNA2 NOS2 IRF-1 PAF1 STAT2 IRF7 PARP1 IRF3 TLR3 PRL NFATC2 RELA STAT4 IL-21 JAK1 FADD SASH1 TIRAP MAVS PMC3006290__F1 Proposed signaling scheme for ischemic preconditioning GC GSK3B PMC3251883__F4 Proposed mechanism for VEGFA165 induced tumour growth RUNX1 IRF7 SOS2 VEGFA SMAD4 CREBZF IFNG IL7 TIMP1 IL7R CXCL9 SOS1 TF DKFZp781O1323 PMC7693908__F1 Oxygen sensing mechanisms RGS4 VHL KDM5A PMC4398619__F5 Diagram of EGFR signaling pathway showing impact of gefitinib and erlotinib on EGFR downstream signaling proteins GRB2 SRC STAT3 CBL PMC4572003__F2 Network integrating gene–metabolite associations and metabolite–metabolite correlations RNF167 ALOX12 SNAI2 PAH MBOAT7 GOT2 ACADS SCD APOA5 APOE GLS2 HEL-S-61p CYP2C9 FADS1 PAOX SPTLC3 LIPC OPLAH SGPP1 SLC13A5 GADL1 GCDH ACSM2A ACSM5 NUBP2 AHR DMBX1 SCAPER DDC SLC6A12 SLC7A6 IVD ASPG AGXT PDXDC1 SLC6A20 KNG1 ANKH ALX3 HEATR4 SH2B3 MGAM GCKR SLC16A10 HPS5 PM20D2 PEX5L NAT8 ABO NASP PYROXD2 ALDH18A1 KLKB1 PHGDH hCG_1998026 TDO2 SLCO1B1 GMPR ABCC1 PRODH PSPH ELOVL2 ACADM PMC9093043__F1 Metabolic and epigenetic landscape of HSCs and downstream progenitors HEL-S-26 CYP26B1 PC IDH3B PMC7544743__F1 MAL structure, pathway and dependent immune responses during infections SOCS2 TLR9 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 BTK LTA SOCS1 TAB3 MAL PMC10374606__F8 Prx II knock-down HaCaT cells are sensitive to H2O2 stimulation APAF1 GSK3B PRX PMC6447671__F8 PKZ-mediated signaling pathway IRF9 IRF3 ZDHHC1 PMC551522__F1 The Wnt signal transduction cascade DAAM1 APC RHO PMC3293992__F11 Suppression of the NFKB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity TLR8 TLR7 TLR4 TLR9 PTGS2 TRAF6 IRF3 IRAK4 IL6 MYD88 MAP3K7IP1 PMC7724953__F1 MTOR pathway TSC2 EGF TSC1 EGFR PTEN TNF IRS1 RHEB PMC4653686__F10 Proposed model of the pro-apoptotic pathway GAPDH/Siah1 in high glucose-induced human retinal pericyte apoptosis SIAH1 NONO HEL-S-162eP PMC2998162__F2 Schematics of the Hippo pathway in flies and mice APP SCRIB KERA PMC12155351__F5 Δ-9-THC-dose-dependent pathways and associated genes found in disease-specific pathways CXCL1 SQSTM1 TFRC FOSB SAT2 PFKP JUN HK2 PRKAB2 GCLM GCLC LCN2 FTL CXCL2 FICD SELENOK HEL-S-68p ZNF664 LCMT1 NFKBIA EGLN3 TSC1 PUM2 CLK1 BBC3 AAK1 SEC22B ENO2 BNIP3 PPARG PMC5712298__F1 Immunohaemostasis and infection TFPI MPO TF PMC9066210__F4 Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers IGF1 FOXA1 PMC3100780__F3 Integration of BMP, FGF and Wnt signalling at the level of Smad1 during neural induction LRP5 LRP6 SMAD1 PMC3448443__F2 Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease TSC2 PTEN MTOR RHEB PMC219066__F1 Tocopherol biosynthesis in plants KIN GGPS1 PMC7603366__F2 Dysregulated DNA damage response genes involved in pro-proliferative and apoptosis resistance characteristics of PAH-PAECs BMPR2 ATM UBR5 ATMIN EIF2AK4 RAD51 PAH BRCA1 PMC8799118__F5 Discovered differentially expressed lncRNA AC010973.2 can act as a diagnostic and prognostic biomarker for colon adenocarcinoma EGF BAD AREG POLK ERG SMAD2 TGFBR1 APC SMAD4 RHO MTOR CASP3 GRB2 CCND1 DCC TGFA BAX PMC8910341__F1 Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits BTK CD72 BCL10 BCR GC CD22 LYN SYK CD19 PMC7893122__F1 Hedgehog signaling pathway and representative inhibitors of SMO, GLI and BRD4 SUFU PTCH1 GLI3 CCND1 SMO BRD4 PMC3178431__F6 p63 signaling in cancer cells TSC2 APC GSK3B PTEN RHEB STAT3 PMC4107983__F1 Transcriptional programs controlling endocytosis TFEB EGFR HIF1A PMC3695880__F1 The wiring diagram of the UPR model ATF4 EIF2A MBIP PMC3166148__F3 The citric acid cycle pathway (reprinted from KEGG ) ACO2 SUCLA2 SUCLG2 HEL-S-32 PMC5923365__F1 Cellular pathways affected by genes significantly mutated in ALL BRAF EGFR PTEN MTOR CBL TSC2 ATM PTPN11 MDM2 GRB2 FLT3 ARAF SH2B3 PMC8781990__F4 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host CS ADA PMC5362592__F1 Different pathways induced by ALS proteins converge on translational repression MAP1B EIF2A HEL-S-44 RAC1 FUS PMC8781990__F5 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host APP GIN1 PMC3574819__F10 O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation ATM ATR H2AX PMC12203532__F5 A) GNN explainer outputs node and edge importance for each sample CD200R1 DPT UBE3B PMC7918973__F1 Nrf2/ARE signaling pathway MAF GCLM KEAP1 GCLC NQO1 PMC8526709__F3 KEGG enrichments of DEGs in protein-protein interaction network (PPI) PDE4D EGR1 MAFB CASR LRP6 CYP24A1 HBEGF PTH ARHA FGF23 FGFR1 NR1i1 JUND SP1 GATA3 GCM2 PMC7431487__F1 Antiviral signaling pathways induced during viral infection TBK1 TANK IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 ISG15 TLR8 TLR7 IRF-1 MAVS PMC4403607__F12 Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity CCND1 CDK12 CDK4 CDC2 MTOR BAX PMC7145358__F3 Intra- and intercellular modulation of melatonin synthesis ME1 GC AANAT PMC8417798__F9 Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3–SOCS3 Pathway SOCS3 WNK4 STAT3 PMC6628922__F5 Gestational Binge Alcohol-Induced Alterations in Maternal Uterine Artery Transcriptome FER CYBA VASP AAK1 F2 RAC1 CRK MME PXN THY1 PMC5686665__F1 Lipogenesis, sphingolipid, and PA synthesis pathways UGCG ACLY CERK KDSR FASN PMC6497434__F1 New mechanistic insights into modifiable risk factors that promote pancreatic cancer CXCR4 CXCL12 STAT3 PMC5495030__F1 Canonical TGFB signaling pathway SMAD2 SMAD4 SKI PMC4649510__F7 Model of tissue homeostasis maintenance after an ER stress HEL70 ATF4 RAC1 XBP1 PMC6405822__F1 BMP signal transduction SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7279047__F1 Aryl hydrocarbon receptor (AhR) signaling pathway AIP AHRR AHR CYP1B1 CYP1A2 PMC9496836__F1 Sirtuin 1 in Host Defense during Infection MTOR TGFB1 DKFZp686F0183 SIRT1 PMC8782557__F1 Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases ATM PARP1 IRS1 SIRT1 MLST8 PMC6168922__F5 Signaling via the ALX/FPR2 receptor FPR1 APP FPR2 PMC7849055__F5 Diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence GSK3B PTEN IRS1 CD36 PMC3934462__F1 Apoptosis signaling and cell death relevant drugs TRADD APAF1 FADD BAX PMC11040941__F6 C6orf15 promotes liver metastasis via WNT/Beta-catenin signalling in colorectal cancer LEF1 CPT1A PMC2685877__F1 Combined Yeast-derived Beta-Glucan with Anti-tumor Monoclonal Antibody for Cancer Immunotherapy TH APC CD40 PMC5492892__F1 Molecular networks between genes involved in NB development by the data mining IPA software CHEK2 PALB2 ALK MMP20 BCL2 BRCA1 TERT PMC3753504__F39 Activation of different death receptor signaling pathways depending on the culture conditions of hepatocytes DIABLO HTRA2 FADD BAX PMC2906263__F3 Suppression of IFN-induced Jak-STAT signaling in hepatitis C PRMT1 SOCS3 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 IFNLR1 USP18 PMC6318427__F2 Current model of iron sensing in the liver to regulate hepcidin production BMP6 HFE FURIN TFR2 PMC12153880__F1 The cGAS/STING pathway TBK1 CGAS IRF3 PMC5070595__F2 Relevant aspects of complement activation and inflammasome activation with their possible interconnection HEL-S-62p NLRP3 IL1B PMC7574648__F7 Model summarizing the functional relationship between Rab5-Rab11 GTPases and BDNF/TrkB-mediated CREB transcriptional regulation EGR1 ARC MTOR BDNF PMC7377856__F7 Proposed scheme for the possible mechanism of EA pretreatment suppresses CIR-induced autophagy via the SIRT1-FOXO1 signaling pathway SIRT1 FOXO1 PMC6664092__F6 Overview of QTG involved in organoleptic compound production MAEL SKP2 MDH2 PMC7873566__F3 Formation of the signaling-competent IL-1R complex and downstream IL-1 signaling UBC IRAK1 IRAK2 PTGS2 CXCL8 IL1R2 TRAF6 IL1R1 IRAK4 TNF MAP3K7IP1 TAB3 PMC5876464__F1 Signaling pathway of GRP78 ATF4 PMC2676892__F3 Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors SOCS3 PDE4A NR4A3 AREG SLC2A3 CREM FOSL2 HMGCR PMC9102406__F3 Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System NOD1 AHR KEAP1 EGFR HEL-S-44 CYP1A1 PMC12094572__F3 Molecular mechanisms of exercise-enhanced brain neuroplasticity by enhancing various peripheral factors NLRP3 ADIPOR1 FGF21 APPL1 PMC9526990__F1 Long non-coding RNAs affecting cell metabolism in cancer HEL-S-133P HK2 PMC12094572__F1 Effects of ADPN on metabolism in peripheral organs and related signaling pathways IL15 ADIPOR1 FOXO1 PMC8264452__F1 Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders APC LRBA PMC8215834__F7 Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway SRC IL6 TNF STAT3 PMC3454471__F5 Redox regulation of the Nrf2–ARE pathway MAF KEAP1 BACH1 PMC3541279__F5 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury NGF MADD TBCB SHH ARHA SMO BDNF TRAF2 NTRK2 FADD LINGO1 PMC6933942__F5 Summary of proposed mechanistic pathway of S1PR1-induced mechano-hypersensitivity NLRP3 IL16 S1PR1 TNF IL1B PMC3541279__F2 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury TH BIRC2 NFKBIA BAD TRADD CRH HEL-S-11 LIPI APP CRAT GAL TRAF2 PMC2775236__F1 The effect of neuronal activity on the function of the miR379-410 cluster member miR-134 LIMK1 PUM2 BDNF PMC5416999__F11 Signaling mechanisms for PGF2A and AL-8810 stimulation of FP receptor EGF EGFR SRC HBEGF PMC3002356__F6 Proposed model of GS-mediated apoptosis in HNSCC cells BAD FADD BAX PMC7461721__F5 Signaling Pathways Converge on Profilin MMP2 ROCK1 SMAD2 MMP9 VHL SMAD4 SRC ARHA HDAC1 TF PMC8117212__F3 Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response TLR4 IRF3 MYD88 STAT3 PMC6129509__F10 Pi3k-akt signaling pathway interactions CDK2 CDK4 LAMC1 BRCA1 COL4A1 CCNE1 PMC5511646__F2 Cardiac hypertrophy (a) and cardiac fibrosis (b) signaling pathways GSK3B HDAC5 GATA4 PMC9138861__F7 Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability CXCL1 NFKB2 CXCL5 CD44 CXCL8 IL8RB CDK4 FLT3 CD74 PMC3821580__F2 Schematic representation of the functional/physical relationship between Dystrophin-Syntrophins-nNOS pathway and miRNAs involved in such signaling, both in a WT and a DMD context HDAC2 COL1A1 DMD PMC4642996__F7 A proposed scheme for BRCA1 and Gamma-H2AX-dependent DNA repair in neurons under normal conditions and in HD ATM H2AX BRCA1 PMC2840670__F1 K-ras mutation governs the effects of inhibition of epidermal growth factor receptor (EGFR) on the Ras/Raf/Mek signaling pathway EGF EGFR TGFA PMC6291505__F1 The involvement of several TMEMs in tumor growth through the TGFB signaling pathway TMEM97 GSK3B TMEM158 TMEM88 TMEM14A TF PMC9086835__F7 LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis MTOR HEL-S-133P PMC5501768__F1 Scheme depicting mechanisms of resistance observed to BRAF and MEK1/2 inhibitors in vitro and in vivo BRAF ERBB2 EGFR NRAS PTEN AXL PMC8602198__F2 Contribution of miRNAs in the Pathogenesis of Breast Cancer HMGB1 ATG12 ATG3 SAG SQSTM1 BCL2 UVRAG STX17 ATG10 MTOR SNAP29 DKFZp686F0183 PMC8602198__F1 Contribution of miRNAs in the Pathogenesis of Breast Cancer STAT1 CASP3 BAD TRADD ROCK1 CASP9 SRC PTEN FADD STAT3 BAX PMC3952073__F4 TAK1 Regulates Hepatic Cell Survival and Carcinogenesis YAP1 SMAD2 SMAD4 TBR1 BAX PMC5796038__F3 Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis NKAP PLA2G7 RSPO3 HEL-S-78p LILRA4 A4GALT TNF SERPINA3 ORM1 GPR119 PMC3753504__F28 Influence of hepatocyte culture conditions on signaling and phenotype SMAD2 SRC PMC8547927__F3 PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations BRCA2 PARP1 BRCA1 PMC8336336__F6 Diet-derived transmission of MicroRNAs from host plant into honey bee Midgut ROCK2 BAMBI INVS CBY1 STOM APC SOST LRP5 CER1 SMAD4 LRP6 SKP1 RYK ARHA NLK DAAM1 SIAH1 PMC5862799__F3 The metabolic pathways utilized by T cells in nutrient replete versus metabolically challenging environments HIF1A MTOR FOXP3 PMC9427288__F2 Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs CDA DPYD CES2 SLC22A7 UCK2 RRM2 DPYS UPP2 TYMS UMPS TYMP CYP2A6 PMC8903693__F4 Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them? APAF1 CDK2 MDM2 CDK4 CDC2 BAX PMC2787730__F9 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cytokine and cytokine-receptor interaction pathway CCR2 IL3RA CCR3 CCR6 CSF3 IL9 CSF3R CCL21 CCL7 IL11 CSF2RB IL6R CCL16 CCL14 CCL13 CNTFR CCR7 IL7R CTF1 IL2 LEPR CCL19 CCL25 IL4 IL9R CSF2 IL2RB LIF CCR4 CCL4 IL6 CNTF IL15 LEP IL7 CCL15 IL3 IL2RG CCL20 IL15RA IL2RA IL-21 IL11RA CCL23 OSM CCL3 PMC4074572__F1 Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology NLRP3 CXCL13 CXCL1 TLR4 CCL5 CXCL2 MYD88 MTOR CCL3 PMC7806239__F7 Positive Feedback Loop Between TGFB and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance SMAD2 SMAD4 PMC5666340__F4 CyaA toxin of B.pertussis inhibits the TRIF-dependent signaling pathways in human monocyte derived dendritic cells (MDDC) STAT1 TLR4 TRAF6 IRF3 MYD88 TIRAP PMC8303609__F4 KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease HLA-G ZAP70 GRB2 SYK LAT PMC7013742__F2 Putative SUR1 molecular signaling pathways beyond cerebral edema in brain injury TLR4 PLG GFAP TRPC3 CCL2 NOS2 SP1 PATE1 BAX PMC1421301__F1 Interferon Regulatory Factor Expression in Human Breast Cancer STAT1 MHC2TA IRF2 PMC3420877__F8 Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice EGF EGFR SRC PMC10935305__F9 Graphical illustration of the interaction between the gut microbial SCFA-induced Nrf2 redox signaling pathway and LPS/ROS facilitated systemic inflammatory cytokines NLRP3 COX2 GSTA4 TLR4 TRAF6 MYD88 NQO1 PMC7308735__F3 GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease TNFSF11 MMP9 MYC CSF2 GPNMB PMC4526263__F1 Cellular alterations and molecular mechanisms involved in hepatic cystogenesis TRPV4 IGF1 HIF1A MTOR SEC63 CFTR PMC1877091__F15 PDCD10/MST4 signaling pathway and CCM protein function PDCD10 PMC2856329__F9 Brx-mediated osmotic stress-activated signaling system and its implications for the immune response NFAT5 LTB RAC1 IL1B CDC42 PMC3735826__F5 miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients RS1 EGLN3 PRKCE BIRC5 FOS SMAD2 VHL VEGFA HDAC2 NR3C2 PTEN PMC7387202__F1 IGF system and its components IGF1R IGFBP1 IGFBP2 IGFBP6 IGFBP5 IGF2R PMC7937875__F7 Canonical pathway analysis FGA SAA4 ADAMTS2 CS XLKD1 IL6 S100A9 PPBP SERPINA3 HMFT1766 SELL HEL-S-78p HSPG2 TIMP1 A2M VCAM1 CFH opn B2M SGK1 PMC5384577__F2 Possible roles of Mgs1 and WRNIP1 in DNA transaction FBXO18 ATM WRNIP1 BRCA2 ATMIN RAD52 RAD51 POLN MRE11A RAD18 PCNA PMC8209977__F1 Homologous recombination, cancer and the ‘RAD51 paradox’ PALB2 IMPACT BRIP1 RAD51D BARD1 PTEN BRCA1 CHEK2 NF1 ATM BRCA2 STK11 RAD51 XRCC3 RAD51C PMC7028932__F2 Oncogenic pathways activated in T-ALL, the downstream signalling network of interleukin-7 (IL-7), NOTCH1, and polycomb repressor complex 2 (PRC2), and potential therapeutic targets NOTCH1 PTEN EZH2 MTOR FBXW7 SUZ12 EED PMC8990307__F2 Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration NLRP3 TLR4 IRF3 GSDMD PMC4177363__F5 Transcriptional response to dietary restriction in Drosophila melanogaster UTP6 UTP4 IMP3 NMD3 IMP4 PWP2 UTP18 LSG1 EMG1 NHP2L1 DRG1 DKC1 NHP2 RAN NOP58 COMP NOP10 NOB1 POLI PMC7653638__F5 FGFR1 and KLB effect on endocrine vs canonical FGF signaling FGF21 FGFR1 FGF2 PMC2566006__F2A A Defect in Menadione Biosynthesis Induces Global Changes in Gene Expression in Staphylococcus aureus CDA PDC SDHC SUCO GAPT ADA HEL107 GLA SDHA SDHB PMC6698547__F2 LMP-1 rescues Smads from Smurf1-mediated proteosomal degradation SMURF1 SMAD1 DKFZp781O1323 PMC5955428__F2 Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk EGF MOS GRB2 BDNF PMC3464734__F2 Pre-treatment expression of TLR, RIG-I and IFN-beta pathway genes compared between the two patient groups PIK3R1 IKBKE SOCS3 TLR9 MAPK8 IRAK1 ATF2 MAPK14 TRAF3 TRAF6 EIF2AK2 IRAK4 MYD88 ZBP1 ISG15 OAS1 TLR7 TLR4 JUN RSAD2 STAT2 IRF7 IRF9 CXCL10 IRF3 IFNB1 NFKBIA ISG20 TNFSF10 CSA2 IFIH1 TIRAP MAVS PMC7486775__F1 Candidate pathways supporting phosphoglycolate salvage in C PDHA2 MAEA PDHA1 PMC3366012__F2 TNIP1-mediated signaling pathways CASP3 TRADD EGFR TRAF2 CASP8 FADD PMC3217196__F1 MicroRNAs in Mutagenesis, Genomic Instability and DNA Repair ATM CCNG1 ATR H2AX CDC42 PMC6202849__F2 Schema of deriving corneal cell phenotype from iPSCs SOX2 NODAL CSK ABCB5 TFAP2A SOX10 ABCG2 PAX3 SOX9 BMP4 PMC8508869__F1 Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway SRC MTOR STAT3 PMC5323160__F10 Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis FYN VEGFA SRC SHB CDC42 PMC7697192__F2 Kin regulates macrophage polarization through MAPK, NFKB, and STAT6 signaling pathways IL10 KIN IL6 ARG1 IL1B PMC4384220__F1 PI3K-Akt-mTOR signaling pathway TSC2 BAD TSC1 MDM2 PTEN RHEB PMC8645962__F1 Acetylation in Tumor Immune Evasion Regulation SIRT2 HDAC3 HDAC10 HDAC8 HDAC7 HDAC11 HDAC5 HDAC1 FOXP3 SIRT3 IFNG SIRT7 SIRT4 SIRT5 SIRT6 HDAC2 JAK1 SIRT1 PMC3808414__F8 Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy TMEPAI PDPK1 PMC8289466__F10 Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer HEL-S-11 APP ENG KEL PMC11019597__F3 Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review MMP3 MUSK LRP4 PMC5323150__F12 SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride GADD45A SIRT1 PMC3745317__F1 Eicosanoid biosynthetic pathway and its activation by RTK/GFR → ERK1/2 signaling COX2 COX1 EGFR PMC7352599__F2 SRC constitutive activation modulates inflammation and metabolism concurring to tumor microenvironment sustainment in GBM SRC STAT3 PMC7059830__F1 Glycolytic-lipogenic pathway in TH17 cells MYC MTOR HEL-S-133P HMGCR HK2 PMC9241288__F2 Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update COX2 MSC CD44 VEGFA GDNF AQP4 BDNF PMC2991775__F1 Pathways leading to the type I interferon production IL10 HMGB1 TBK1 CD14 TANK TLR9 IRF7 TRAF3 IRF3 TLR3 RNASEL TLR8 RNASE1 BTK TLR7 TLR4 opn EIF2A AIM2 FADD TIRAP MAVS TAB3 PMC3186862__F1 BAD pathway in genes associated with induced cisplatin-resistance BAD MAPK13 IGF1 EGFR GRB2 CDC2 HRAS IRS1 PDPK1 PMC5116261__F1 PI3K signaling: a molecular pathway associated with acute hypophagic response during inflammatory challenges TSC2 POMC TSC1 LEPR PTEN MTOR RHEB INSR STAT3 PMC4091817__F2 The oxidative stress regulatory pathway in erythrocytes HEL-S-2a GPX1 HEL-75 HEL-S-44 TXN PMC5945837__F8 Galactose metabolism pathway in Streptococcus pneumoniae D39 TBP GAL PMC5832136__F6 Anti-liver cancer mechanism of TF BAD PTEN TF BAX PMC7608107__F7 A proposed working model wherein miR-210 positively regulates microglia-mediated neuroinflammation via activating the NFKB signaling pathway by targeting SIRT1 and blocking p65 deacetylation IL6 IL1B SIRT1 PMC10934612__F3 Gene regulation in fatty acid metabolism pathways by GFIPO compared to WEGG APOB LIPE GPAT4 ACACA ADA LPA TG CIDEA MTTP FASN PMC3406244__F3 Thyroid Hormone Receptors and Cancer MMP2 MMP9 SRC SP1 MTOR CP ELL PMC11010636__F2 Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy CXCR3 CGAS NOD2 PMC7551725__F2 Tryptophan (Trp) metabolism and AhR pathway in health and disease IDO1 AHR STAT3 PMC3441782__F6 Molecular network of downregulated genes in U373MG cells following exposure to ET-770, the compound 1a BAD BTC SHE JUN POTEA PMC3441782__F7 Molecular network of upregulated genes in U373MG cells following exposure to ET-770 derivative, the compound 3 CDC20 E2F4 CDK2 RAD21 PCNA MIB2 SKP2 MAL PMC3387019__F7 Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss MMP3 ACE2 PMC6479968__F1 Protein C activation by the thrombin-thrombomodulin complex and the cytoprotective function of Activated Protein C (APC) in ischemic heart disease and heart failure PC APC RAC1 PMC9244704__F10 Integrated Metabolomics and Transcriptome Analyses Unveil Pathways Involved in Sugar Content and Rind Color of Two Sugarcane Varieties GNS TREH GYG1 PMC4377327__F5 Regulation of microRNA function in somatic stem cell proliferation and differentiation VAV3 SKP2 MSI2 PMC8301030__F1 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans PTS HIST1H1E PMC4377327__F6 Regulation of microRNA function in somatic stem cell proliferation and differentiation CTDSP2 HES5 FOXJ3 PDGFRA PTBP1 REST SOX6 SOX9 PMC5082389__F5 IL-17 F signaling pathway is epigenetically altered in malignant COPD and non-malignant COPD lung airway epithelial cells CXCL1 LCN2 IL17RC PMC8301030__F9 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans EGF BAD WNT3A GSK3B PMC8497904__F6 Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway NR5A2 HSD3B1 CYP11A1 PMC3185611__F1 PRRs involved in detecting flaviviruses IFNA1 TRAF3 TRAF6 IRF3 TLR3 PMC9338538__F3 Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions HEL-S-62p HEL-S-11 VWF PMC4648419__F5 Enriched pathway of Integrin (A) and migration (B) MYH9 HEL2 FLNA EMILIN1 ACTN1 HEL-S-99n PDIA4 MYL6 EZR ITGA7 TLN1 FLNB PAH HEL114 ACTN4 MVP APOE ITGA1 HEL-S-89n PLEC PARP1 HEL-S-22 HEL-S-125m CANX HEL-S-269 HEL113 HEL-S-93 MYLK PMC9083130__F7 Integrin A4 up-regulation activates the hedgehog pathway to promote arsenic and benzopyrene co-exposure-induced cancer stem cell-like property and tumorigenesis SUFU ITGA4 PMC2443667__F1 Connections between the SAM cycle, transsulfuration pathway, and glutathione production CTH HEL-S-61p MTR GCLM GCLC HEL-S-64p PMC5167048__F3 Age‐associated defects interfering with function and survival of activated T cells STAT1 DUSP4 EGR1 CD69 PMC7017935__F12 Antral follicle steroidogenesis HSD3B1 HSD17B1 STAR PMC8535158__F4 NUAK Kinases: Brain–Ovary Axis NUAK1 IGF1 MMP2 SMAD2 MMP9 HDAC1 TF PMC2785127__F5 Putative targets of common changes in gene expression with single and repeated IMO stress TH FOS PARG PMC4447104__F1 Bacteria, the ER and the Unfolded Protein Response: Friends or Foes? ATF4 EIF2A XBP1 PMC5968105__F1 Senescence-associated secretory phenotype (SASP) is regulated by an interactive network of pathways that dictate its functional outcome CXCL1 ATM EBP NOTCH1 CXCL2 MTOR PMC5634503__F7 Proposed mechanism RAB1A RPE TF PMC11904505__F3 Endometrial carcinoma (EC) cells strategically employ immune checkpoint pathways, with a notable focus on the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis PMC4245458__F2 Regulatory cross-talk between the estrogen receptor alpha and MTA family members GRB2 MTA2 MTA3 PMC8773035__F1 Exosomal microRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control ACSL6 HOXA11 VEGFA PTEN RPS15 TNF EPHB6 VASH1 PMC9408827__F3 Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities ALPL RUNX2 COL2A1 COL9A1 COMP COL10A1 PMC12174428__F1 IFN signaling in beta-cells and autoreactive T-cells (inset) via JAK/STAT pathway in T1D HLA-E STAT2 IRF9 CXCL10 ATF3 IFNGR2 XBP1 IFNLR1 STAT1 TYK2 JAK3 JAK1 IFNGR1 PMC8313993__F1 Metabolic pathway map illustrating high-value bioactive ingredients for food, agricultural feed materials, human health, and well-being products, provided by Corynebacterium glutamicum cell factories STS PROC IPP PMC3814639__F2 Schematic model of the Nrf2–Keap1 signaling pathway MAF GCLM KEAP1 RBX1 PMC3814639__F3 Cross-talk between Nrf2 and other proteins MAF DPP3 KEAP1 RBX1 PMC3262331__F2 Schematic signaling pathway mediated by the L-CBM complex in T and B lymphocytes.Notes: The L-CBM complex acts in the canonical NFKB (p65/p50, cRel/p50) activation pathway mediated by IKKB downstream of TCRs and BCRs TLR4 BCL10 BCR RELB TRAF6 MYD88 PMC3262331__F3 Schematic signaling pathway mediated by the L-CBM complex in NK cells.Notes: The L-CBM complex acts in the canonical NFKB activation pathway through activating NK cell receptors (NKR) such as Ly49H, Ly49D, NK1.1, NKG2D, FcGRIII, etc BCL10 VAV1 RAC1 MYD88 PMC4393718__F2 EphA/ephrinA bidirectional signalling HEL-S-28 RRAS SRC RHO CRK CDC42 STAT3 PMC7237878__F1 Possible associations of the renin-angiotensin system with SARS-CoV-2 infection and lung injury caused by SARS-CoV-2 ACE2 ADAM17 TMPRSS2 PMC6225117__F1 Molecular mechanisms of (-)-epigallocatechingallate (EGCG) suppressing the proliferation of cervical cancer cells IGF1 CDK2 EGFR MTOR PMC9179436__F1 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment STAT2 TYK2 JAK1 PMC9179436__F2 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment WNT3A AHR STAT3 FOXP3 PMC3536343__F1 MTORC1 signaling to the translational machinery TSC2 EEF2K TSC1 EEF2 MAF1 PTEN RPS6 DEPTOR EIF4B RHEB PMC8745410__F1 Development and Use of Akt Inhibitors in Prostate Cancer TSC2 TSC1 PTEN MTOR PMC3536343__F4 MAPK signaling to the translational machinery TSC2 EEF2K TSC1 EEF2 EIF4E RPS6 DEPTOR EIF4B RHEB PMC4429241__F2 Signal transduction pathways activated by DNA to stimulate type I IFN expression TBK1 CGAS TLR9 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 ZDHHC1 TRIM25 AMFR TRAF5 TRAF2 MAVS BAX PMC9028356__F1 Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer ABCB6 FECH UROD SLC25A38 UROS HMBS CPOX ABCB10 ABCG2 PMC11061161__F3 Amino acid metabolism modulates T cell survival and lineage commitment TH MTOR PMC7766764__F4 Regulatory network for fungal dimorphism in U CIB2 HEL-S-8a CDK5 CLP1 PRF1 RAC1 MED1 ROS1 PMC9473615__F7 SAMD9 effect to DNA sensing pathway and proinflammatory responses CGAS IRF3 SAMD9 PMC11061161__F1 T cell activation and subset differentiation and function by lipid metabolism CPT1A SULT2B1 AQP9 STAT3 CD36 PMC10882095__F5 Immune molecule interaction network in the blood and heart tissues of chronic Chagas disease (CCC) patients CXCL10 CXCL9 CCL5 CCL2 IFNG PMC2575513__F2 Diversification of the innate immune arsenal in amphioxus NAIP TLR4 NOD1 MYD88 TNF NOD2 TIRAP PMC4106758__F6 Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A SOX2 IGF1 PAK6 FGF2 GLI3 VEGFA SHH NOTCH1 PROX1 PMC4429241__F4 Signal transduction pathways activated by DNA to stimulate activation of inflammasomes and the NFKB pathway CARD9 IL18 RAD50 MRE11A AIM2 IL1B PMC7662426__F3 Molecular signaling pathway of PA28G in cancer MDM2 SIRT1 PTTG1 PMC4429241__F5 Endogenous and microbial mechanisms to downmodulate and evade DNA-driven innate immune responses TBK1 CGAS ULK1 DNASE2 TREX1 ATG9A TRIM25 AIM2 NLRC3 MAVS IFI16 PMC6608593__F4 PANTHER Pathway: an ontology-based pathway database coupled with data analysis tools RAF1 ADRBK1 PMC5570578__F7 Illustration describing the role of HPV E6/E7 oncogenes and HPV E6/E7 siRNA with cisplatin (CDDP) plus paclitaxel (PTX) therapy on HPV-infected cervical cancer cell fates ATM CDK2 ATR PMC11063389__F2 Therapeutic targets and inhibitors targeting JAK2/STAT3 signaling pathway for TNBC treatment GAA STAT3 PMC5369176__F1 Physiological functions of PD-related Rabs RAB35 RAB32 RAB10 RAB13 PMC5361605__F4 GIST and apoptosis signaling CASP3 CASP6 BAD APAF1 BIRC5 CASP9 BCL2 DIABLO CYCS BAX PMC7092730__F1 Three adipogenic transdifferentiation pathways EHMT1 PRDM16 IGF1 MYF5 EBP BMP2 PAX7 MSX1 EBF2 PMC3321615__F1 Canonical and noncanonical pathways of NFKB activation CD14 TLR4 RELB CD40 PMC9264937__F3 p53 Isoforms as Cancer Biomarkers and Therapeutic Targets RAD51 BAX PMC10967338__F2 EGFR wild type and EGFRvIII mutated comparison EGF BTC EGFR TGFA PMC7936186__F6 Schematic representation summarizing the integrated effects of PFA-enriched diets on intermediary metabolism in the broilers RPS6KB1 LIPC PFAS MTOR PMC10485805__F1 Intestinal flora regulates tumor microenvironment components TLR4 CTSK TNF STAT3 PMC10299676__F1 Mechanisms for activation of the JAK-STAT signaling pathway TYK2 JAK3 JAK1 PMC10967338__F7 TGFB canonical intracellular pathways and single-domain vNAR T1 coupled to TGFB1 SMAD2 SMAD4 PMC6114229__F1 Schematic presentation of MAPK/Ras signaling pathway EGF EGFR GRB2 PMC10967338__F3 Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation TSC2 EGF TSC1 BTC EGFR GRB2 PTEN TGFA RHEB STAT3 PMC10967338__F4 IL13RA1/IL4RA JAK-STAT6 pathway, IL13RA2, and single-domain vNAR coupled to IL13RA2 IL13RA2 IL13RA1 PMC10967338__F5 Allosteric inhibition of Aurora-A kinase by the vNAR-D01 intrabody EGF CLDN1 TBX2 EGFR GSK3B HCTP4 BRCA1 AURKA BRCA2 MDM2 RAD51 STAT3 BAX PMC7804955__F7 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity IRF7 IFNE NDUFB2 MAVS PMC5677022__F3 10-miRNA-score predicts defects in the HR pathway in ovarian cancer PLK1 BRAF FOXM1 FANCD2 BIRC5 EMSY PTEN CDC25B RB1 CDKN2A BRCA1 AURKB CCND2 CCNE1 CHEK2 NF1 ATM BRCA2 CCNB1 CCND1 RAD51 ATR PMC8036376__F1 Metabolic pathway of clopidogrel and its target receptors CYP2B6 CYP2C9 CES1 CYP2C19 ABCB1 CYP1A2 PMC9614394__F11 Schematic mechanisms by which Wnt agonist 1 (Wnta1) regulates atrial atrial natriuretic peptide (ANP) secretion and mechanical dynamics LEF1 TCF3 ATF2 MAP3K7IP1 TCF4 PMC8594875__F8 S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells NKX2-5 GSK3B PMC7686704__F2 Wnt–PCP signaling pathway in mammals INVS MUSK PTK7 ARHA INTU RYK RAC1 CELSR1 CDC42 PMC7686704__F3 Wnt–Ca2+signaling pathway in mammals NLK ATF2 RYK STIM1 STIM2 CDC42 INSR PMC11141153__F6 AMPK signaling pathway depicted using KEGG in tissue lysate fractionThe levels of upregulation of the proteins observed in AMPK pathway are as follows: CAB39/MO25 log2 0 TSC2 IGF1 F2 PDK2 INS PPP2R1B CAB39 MTOR RHEB CFTR INSR CD36 PMC7686704__F1 Canonical Wnt signaling pathway in mammals ZNRF3 RNF43 APC SOST NOTUM LRP5 LRP6 TNKS RAC1 GPR49 SIAH1 IGFBP4 BCL9 PMC7686704__F8 Wnt signaling in breast cancer drug resistance CYP2B6 CYP2C9 CYP2C19 CYP3A4 ABCG2 ABCB1 CYP1A2 PMC8955684__F2 Angiopoietin-Like Protein 4 and Insulin-Like Growth Factor-1 Expression in Invasive Breast Carcinoma in Young Women BAD IGF1R IGF1 IMPACT BCL2 MTOR STAT3 PMC5925582__F7 Illustration of p204 function in LPS/TLR4 signaling pathway TBK1 CD14 TANK IRAK1 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC5159240__F1 Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu BAD FOS MYC MDM2 GRB2 CCND1 PTEN SP1 HSF1 DMP1 JUN PMC12026008__F2 Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features TLR4 KEAP1 MTOR PMC4208300__F3 Simplified outline of the MyD88-signaling pathway by which TLR agonists induce the production of inflammatory mediators IRAK2 TRAF6 IRAK4 MYD88 TNF CRTC3 TAB3 PMC5949249__F1 To Eat or Not to Eat – The Metabolic Flavor of Ferroptosis GPX4 GC ADA GLS2 TFRC SLC38A1 PMC5809773__F2 Biosynthesis of galactolipids in the chloroplast envelope membranes in Arabidopsis HEL-S-11 GAL PMC3175721__F6 Models for context-dependent ICL repair during replication FAN1 SIX4 PMC3874238__F2 Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism PDE3B BAD SOCS3 EHD1 PTEN EIF4E TNF CRK IRS1 RHEB TSC2 ASIP TSC1 FYN GRB2 GRB10 PMC4114929__F3 Importance of RhoGTPases in formation, characteristics, and functions of invadosomes VASP ARHA CDC42 PMC11928533__F3 Diverse biological functions of the CRIP family CXCL1 CXCL5 APC CREB1 CCL5 MTOR IFNG BBOX1 VEGFC CRIP2 CRIP1 STUB1 ATOX1 CCND1 BAX PMC8904073__F7 Dickkopf-3 and Beta-catenin play opposite roles in the Wnt/Beta-catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis DKK3 APC GSK3B LRP5 LRP6 PMC4870363__F1 Schematic overview of TLR signaling pathway in neutrophilic and eosinophilic asthma TLR8 TLR7 TLR4 MYD88 IL1B TLR3 PMC8227265__F1 Enhancing Sesquiterpenoid Production from Methane via Synergy of the Methylerythritol Phosphate Pathway and a Short-Cut Route to 1-Deoxy-D-xylulose 5-Phosphate in Methanotrophic Bacteria SCO2 CIT IPP MAL PMC4439431__F1 Metabolism of a resting uninfected cell ACACA ACLY HMGCR FASN PMC6763723__F1 VLC-SFA and VLC-PUFA elongation pathways ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL7 ELOVL6 ELOVL2 PMC4439431__F2 Metabolism of a cell infected by HCMV COX2 ACLY HMGCR FASN PMC4439431__F3 Metabolism of a macrophage activated by immune signals COX2 ACACA ACLY HMGCR FASN PMC7982634__F3 Natural extracts exert inhibitory effects on PI3 K/Akt signaling pathway BAD GSK3B MDM2 CASP9 PTEN RPS6 GATA4 PMC7982634__F4 Natural extracts block NF‐KB signaling pathway TRADD ECSIT MYD88 TNF TRAF2 PMC7982634__F1 Natural extracts can induce apoptosis through ERS pathway and mitochondrial pathway CASP12 ATF4 BAX PMC7340679__F1 Anticancer activity of mistletoe CDK2 CCND1 BCL2 CDK4 MCL1 PMC11728246__F2 TRAPPC4 and TRAPPC9 in cell signaling RELB TRAPPC4 TRAPPC9 PMC11118191__F2 Overview of USP36-mediated signaling pathways ANKRD1 FXR1 MDM2 PARP1 LATS1 USP36 CEP63 LATS2 HK2 PMC7470069__F5 Mercury-sulfhydryl-dependent effects on apoptosis regulation KEAP1 BCL2 PTEN PMC2713245__F1 Signal transduction through activin receptors SMAD2 SMAD6 SMAD4 GDF11 PMC8393314__F1 Glycosylation in Melanoma Progression TH GCNT3 ST3GAL3 PLG EGFR FUT1 FUT4 TG hCG_1998026 MCAM FUT8 F2 GAL AXL ST6GALNAC2 GCNT2 ST6GAL1 ST3GAL5 PMC7340679__F7 Probable mechanism of antiobesity activity of mistletoe LPL PMC7396059__F3 NKG2D signaling pathways VAV1 GRB2 RAC1 CRKL PMC6533528__F7 Schematic model of IL‐1B‐ and Fn‐fs‐mediated ADAMTS‐12 and ‐7 stimulation by Runx2 and Wnt/B‐catenin signalling modulation in OA‐SF ADAMTS12 RUNX2 APC DKK1 COMP IL1B WNT7B PMC7396059__F2 Signaling pathways by NCRs VAV3 VAV1 SYK RAC1 LAT VAV2 PMC6769516__F5 Pathway of the investigated genes involved in apoptosis STAT1 CASP3 SOCS2 BAD CASP9 PTEN TNF CASP8 FADD BAX PMC7940844__F1 Toll-like receptor 9 (TLR9) signaling pathway(s) upon CpG oligodeoxynucleotides (CpG-ODN) stimulation: CpG-ODN is internalized through endosomes where it interacts with the endosomic domain of TLR9 TLR4 TLR9 IRF7 IRF3 IL1B PMC5431817__F4 Summary of the main effects of diabetes and NRG1 treatment in gastrocnemius muscle ERBB4 NRF1 TFAM CD36 PMC2172299__F8 A hypothetical model showing the roles of Fak and paxillin in motile HeLa cells RAC1 CDH2 CRK PMC8002185__F3 Serine/glycine biosynthesis pathway activation in tumor treatment resistance BRAF PSAT1 ATF4 SHMT1 EGFR MYC PSPH HEL-S-51e PHGDH PMC8664605__F6 Integrative Analysis of DNA Methylation and Gene Expression Profiling Data Reveals Candidate Methylation-Regulated Genes in Hepatoblastoma CAP1 CD6 MYC SMAD4 PTEN MTOR DBF4 CDC45 TSC2 CASP3 AIFM2 PERP ATM CDK2 MDM2 CYC1 ATR PCNA BAX PMC5704042__F2 Structure of SCF/c-KIT proteins and downstream signalling pathways BAD CDK2 LYN GRB2 SRC MTOR CCND3 PMC8002185__F1 Serine/glycine biosynthesis pathway activation in cancer PSAT1 SHMT1 PSPH HEL-S-51e PHGDH PMC4936987__F4 Pathway diagram of the genes in the tricarboxylic acid cycle FH ACO2 DLD OGDH DLAT HEL60 PMC9332011__F1 Hsp90 and Associated Co-Chaperones of the Malaria Parasite GRPR CDC37 PMC8002185__F4 Linking radiotherapy resistance and serine/glycine metabolism in the tumor and associated tumor microenvironment PSAT1 PSPH HEL-S-51e IL1B PHGDH PMC4651103__F1 Working figure of the angiogenesis pathway genes FLT1 NR1i1 KDR EGR2 EGFR TGFBR1 TNF IRS1 IL1B PMC4936987__F2 Pathway diagram of the glycolysis pathway ALDOB PC PKLR MPC2 ENO1 DLD PFKM HEL-S-133P DLAT HEL-S-32 HK2 MDH2 PMC8940980__F1 SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets NLRP3 IL6 MYD88 ACE2 TMPRSS2 PMC8818156__F8 CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle CCNB1 CENPF CDC2 BAX PMC12249078__F3 Molecular mechanisms lead to uterine fibrosis SMAD2 SMAD4 MTOR TF PMC7457002__F5 ATF3 plays a vital role in breast cancer GOLPH3 ATF3 PMC3992244__F2 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer TSC2 RICTOR TSC1 AAMP PTEN MTOR SIRT1 PMC3992244__F3 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer TSC2 TSC1 PTEN PMC7029724__F4 Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies EGF BAD APC EGFR MDM2 PTEN TNF PDPK1 PAF1 PMC8856111__F1 CounterAKTing HIV: Toward a “Block and Clear” Strategy? TSG101 CXCR4 PTEN EZH2 MTOR FOXP3 PMC6602147__F10 Proposed schematic mechanism of EBV-associated gastric carcinogenesis via the activation of the PI3K/AKT/mTOR pathway, and its blockade by CMG002 PTEN MTOR ELL PMC6106977__F1 MiR-30a significantly inhibits cell proliferation EYA2 RUNX2 RPA1 ATF3 SEC23A PTEN UBE3C TFDP1 DTL SOX4 HEL-S-26 CCNB1 MTDH EZH2 PMC9703992__F6 Cub pathway RELA EGFR GRB2 RELB RRAS FURIN ADAM17 PMC6106977__F2 MiR-30a significantly promotes cell apoptosis by regulating several relevant effectors RPA1 PTEN MTDH EZH2 PMC5116300__F2 Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease LTA LTB IL4 PMC8323701__F1 Dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans’ nervous system under hypoxia PMC8071069__F5 FoxO signaling pathway and Glycolysis/Gluconeogenesis pathway GADD45B IGF1 PCK1 GCK PTEN RBL2 PMC2834467__F2 Map showing relationship between genes positively correlated with plasma estradiol superimposed on Ingenuity map ANGPTL4 MAPK1 CELSR2 PMC9331192__F2 Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System IGF1 GHR PMC6080611__F2 Molecular regulation in autophagy ATG16L1 MTOR PMC8139665__F9 TLR3 Activation by Zika Virus Stimulates Inflammatory Cytokine Production Which Dampens the Antiviral Response Induced by RIG-I-Like Receptors STAT1 SOCS3 IRF3 TLR3 STAT3 PMC3814227__F2 Autophagy: regulation IRS1 SIRT1 RHEB PMC8799091__F5 Identification of significant genes in non-small cell lung cancer by bioinformatics analyses MYB BAD BCR FRK CYC1 SYK RHO PTEN MCL1 CD19 PMC9033806__F8 Schematic model illustrates the potential mechanisms by which GXYLT1 and GXYLT1S212* promote the metastasis of CRC GXYLT2 EGFR GXYLT1 HES1 PMC3425953__F1 Activity of Wnt canonical signaling pathway in the normal and tumor cells APC CRP GSK3B LRP5 LRP6 PMC3425953__F2 The activity of the EGFR/KRAS signaling pathway in normal and tumor cells BRAF EGFR PMC3425953__F3 The activity of PI3K signaling pathway in normal and tumor cells EGFR PTEN MTOR PMC12170841__F1 Action of sEVs in promoting SC regeneration after SCI: (1) The sEVs alleviate symptoms by modulating the neuroinflammatory response to SCI IL10 CNTF TSG101 FLOT1 CD9 NGF CD63 GDNF IL4 BDNF CD81 PMC11599795__F2 In bladder cancer, YAP1 activity is regulated by YAP1 gene expression, post-transcriptional mRNA modifications, and the activity of the Hippo signaling pathway YAP1 LATS1 LATS2 PMC11599795__F1 Hippo signaling pathway is a key regulator of cellular and systemic metabolism, maintaining organ size and tissue homeostasis by controlling cell proliferation, survival and regeneration YAP1 LATS1 LATS2 PMC8732359__F1 LncRNA Expression Profiles in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets ROCK2 OASL OAS2 OAS3 SDC1 YPEL4 LTB MTOR NOD2 PMC9695301__F3 Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer’s Disease: Dietary Plant Polyphenols CCR2 TLR4 IL1B PMC3671665__F1 Targeting the Sonic hedgehog signaling pathway by compounds and derivatives from natural products PTCH1 SHH SMO PMC10671441__F8 S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells TH HGF APOF CSF3 MYC BCL2 POLI PMC10671441__F9 Human Embryonic Stem Cell Pluripotency Signaling FGF4 NODAL DPPA4 ESRRB LIF FGF2 TBX3 MYC REST DVL1 TERT PMC5100803__F1 Genes associated with the NRF2-mediated oxidative stress response pathway that were differentially regulated in aldosterone-producing adenoma (APA) vs zona glomerulosa (ZG) and ZG vs zona fasciculata (ZF) AOX1 PRKCA GSTA4 SCARB1 KEAP1 FOS GSTM4 GSTA3 JUNB PRKCH PMC10671441__F4 IPA Core analysis of the Epithelial Adherens Junctions Signaling in SW480 AHCY deficient cells with increased expression of LEF1 protein EGF IGF1R SNAI1 HGF EGFR SNAI2 WAS PTEN ARHGAP35 FYN FGFR1 ECT2 NF2 FARP2 HEL114 NANOS1 CDH2 ARHGEF17 ZBTB33 AFDN ACTR2 NAV2 WASF1 YAP1 BAIAP2 ARHA CRK TIAM1 FER IQGAP1 STK11 PMC10671441__F2 Wnt Signaling pathway RUVBL2 NR5A2 BTRC APC MYC MAP3K7 CD44 HNF1A DKK1 CDKN2A MAP3K7IP1 WIF1 MAP4K1 NLK AXIN1 MDM2 NR1C2 CCND1 SFRP1 APC2 AXIN2 JUN TCF4 PMC6917725__F10 Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases TRADD FADD PMC8914339__F1 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer HEL-S-102 STEAP3 KEAP1 HMOX1 PMC8914339__F2 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer GPX4 LPCAT3 FACL4 GLUD1 PMC10341343__F2 Glucose metabolism in cancer cells PDC F2 PFKFB4 PGAM1 HEL-S-133P PHGDH HEL-S-281 HEL-S-68p HEL-S-162eP PMC9101486__F6 High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice VCAM1 TRAF6 IL6 MYD88 TRAF2 TAB3 PMC6652202__F4 Protein-protein interaction network PTEN PS1TP5BP1 TARBP2 PMC8628183__F1 ER signaling mechanisms SRC TF GPER PMC5501721__F1 Extracellular nutrients are required to maintain oncogenic signaling in brain cancer – a critical role for mTORC2 PIK3CA PTEN TF PMC8981655__F3 m6A binding protein YTHDF2 in cancer YTHDF2 UBXN1 SOCS2 PRSS23 MOB3B HIVEP2 LHPP GSK3B VEGFA MYC PTEN TNF MTOR BMF SETD7 AXIN1 KLF4 NKX3-1 PER1 PMC8981655__F4 m6A binding protein YTHDF2 in cancer YTHDF2 AGO2 CXCR4 EGFR SOX10 FOXC2 PMC9597993__F2 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy SOX2 IL20RA APC IL20RB PLA2R1 IL24 JAK1 ICOS STAT3 PMC7722523__F1 Molecular Pathway Activation Downstream of BCR-ABL1 BCR GAB2 GRB2 SMO MTOR CRKL PMC4007780__F1 CADBIOM model for the canonical TGFB pathway SMURF2 TG PMC6312894__F1 From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis TLR4 CCR6 CCL20 IL23R PMC6434849__F7 Interesting putative mechanisms are identified by iPathwayGuide (www.advaitabio.com) on the Glutamatergic synapse and the Chemokine signaling pathways TH DAO SYP CLU PMC8042267__F3 IL23 in the development and activation of Th17 cells IL17A IL6 IL23R PMC4786287__F1 Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling ACSF3 OXSM HTD2 PMC8042267__F4 Therapeutic approaches targeting IL23 and IL17 signaling IL17A IL23R IL12RB1 PMC12251195__F2 Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1)-mediated immune evasion in the tumor microenvironment LAG3 PMC6445045__F1 Schematic representation of the unfolded protein response (UPR) SP2 ATF4 SP1 XBP1 PMC8042267__F1 IL23 signaling in Crohn’s disease STAT4 IL17A IL22 IL23R IL12RB1 STAT3 PMC8042267__F2 IL23 mediated resistance to apoptosis of mucosal CD4+ T cells in anti-TNF refractory Crohn’s disease patients IL23R STAT3 PMC11551676__F1 Wnt signaling pathway APC IFNG PMC11641910__F1 Network of protein interactions involving p21 in diverse cellular processes TSG101 SET MDM2 PCNA STAT3 PMC11641910__F2 Various metabolic pathways involving p21 TIGAR EGF EGFR RRAD PMC4663607__F1 Effects of vitamin K antagonists and direct oral anticoagulants on coagulation F2 GLA TF PMC9000741__F2 Extracellular HSPs: The Potential Target for Human Disease Therapy IL15 CD14 TLR4 PMC3606632__F6 MTOR signaling pathway in KEGG pathway analysis TSC2 RICTOR BRAF EIF4E MTOR EIF4B RHEB PMC7352604__F4 Wt TP53 LUAD females are enriched in antigen processing and presentation pathways with links to longevity CANX HEL-S-99n SUSD3 CTSH B2M TNF HLA-DRB1 IFNG TAPBP PMC102215__F1 Pathways to Lignin Monomers.The “metabolic grid” shown in this scheme incorporates the results of recent studies suggesting previously unexpected substrate specificities for F5H and COMT (; ; ) CAD COCH PMC5179106__F3 A) Protein-protein interaction analysis of 524 AD-related proteins revealed two large protein clusters: the APP network (14 yellow nodes) and the CAD network (11 red nodes) GAD2 CAD GAD1 GFPT1 PMC9550168__F6 SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway SNAI1 IGF1R IGF1 ZEB2 PMC7868988__F1 The main cellular pathways regulated by NNMT NAMPT NNMT SIRT1 PMC1475580__F1 Sequence of events in ATM→ ATR dependent signaling of DSBs in S/G2 cells ATM ATRIP ATR PMC5593528__F8 Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway CDK4 TFAM CDK6 PMC6256083__F5 Proposed anti-inflammatory pathway of beauvericin (BEA) in macrophages (adapted from Yoo et al., ) TLR4 SRC SYK MYD88 IL1B PMC10495754__F1 RIPK3-CaMKII-mPTP signaling pathway RIPK1 PIG59 TRADD RIPK3 MCU RIPK2 TRAF2 RYR2 FADD GLUD1 MLKL PYGL PMC7343132__F6 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection TLR8 IRAK1 IRAK4 MYD88 IL1B PMC7343132__F3 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection CD14 LBP TRAF6 CD40 IRF3 RAC1 TNF FADD TIRAP CPO CD36 PMC2375600__F2 From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy LEP INS FOXO1 STAT3 PMC10981749__F8 Model for the induction of proinflammatory SASP by typhoid toxin TBK1 CGAS IL18 EIF2A ATF3 IFNAR2 IFNAR1 PMC3412720__F3 JAK-STAT signaling pathway EPOR PIM1 CREBBP CISH IRF9 CSF3R MYC SPRY1 PTPN6 CSF2RB CCND3 CCND2 PMC8534790__F5 Review of Bioeffects of Static Magnetic Fields on the Oral Tissue-Derived Cells and Its Application in Regenerative Medicine PDE1C RUNX2 NFATC1 COL1A1 PMC3412720__F4 AKT signaling pathway NFKBIA CHUK IKBKG NFKB1 PPP2CA PDPK1 PMC6046223__F8 Signaling pathway which miR-21 can regulate multiple functions in astrocytes SMAD2 PTEN MTOR PMC7762545__F4A Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach PIK3CD PIK3R1 BAD PPP3CA PPP3CC PLCG2 SPHK2 PRKCA KDR APP SRC CASP9 PTGS2 VEGFA MAP2K2 RAC1 HRAS PIK3R3 SHC2 HEL-S-102 SH2D2A RAC3 NFATC2 PPP3R1 MAP2K1 PRKCB PIK3CA RAF1 PXN PIK3R2 CDC42 AKT3 PMC8658239__F2 Important Role of Endothelium and Extracellular Vesicles in the Cellular Mechanism of Aortic Aneurysm Formation VCAM1 SMAD2 ARHA TRAF2 PMC3057454__F2 Autophagy in Immunity and Cell-Autonomous Defense Against Intracellular Microbes ULK1 WIPI1 WIPI2 MTOR PMC2925029__F3 The IFN-λ receptor signaling pathway STAT1 STAT2 IFNK TYK2 IFNAR2 JAK1 IFNAR1 MX1 PMC7506081__F2 Sterol regulatory element-binding protein (SREBPs) mediate the uptake, efflux, and storage of cholesterol ABCG1 LDLR PMC2168342__F7 Matrilysin and stromelysin-2 differentially control apoptotic transcriptional response PIK3R1 IRAK2 GSK3B MYC HIF1A BMF STAT5B BCL10 HEL-S-44 CSF2 RAD21 MMP10 CASP12 BAG3 MAP3K7 VEGFA TNF DIABLO HTRA2 DIDO1 BTG1 BCL2 LITAF CARD10 SPHK1 UNC5B ERCC2 HSPA1A IRAK3 SIVA1 CASP4 BAD HIPK2 PTEN RIPK2 RARB RIPK1 NR1B3 NGFR BIRC3 APP YWHAG RHOB ARHA IL6 MUC2 DDIT3 CASP3 FADD PMC11004224__F7 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study TLR4 EPO VHL HEL-S-87p HEL-S-133P TF IFNG HEL-S-162eP PMC7506081__F3 Sterol regulatory element-binding protein (SREBPs) is involved in the activation of M1-type macrophages TLR4 CCL2 MYD88 ACLY CCL3 PMC7506081__F4 In tumor cells, the glucose uptake is significantly increased KEAP1 OGT LDLR ACLY MTOR FOXO1 SLC25A1 FASN STAT3 PMC11004224__F5 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study UBC PLTP HEL-S-28 LPL PMC4697149__F1 Enhanced inflammatory gene expression by IL1B; feedback control by DUSP1 and feed-forward control by ZFP36 ZFP36 TNF IL1B PMC11004224__F8 KEGG network diagram of cytokine-cytokine receptor interactionLarge white box: biological pathway map LTA CNTFR LTB TPO TNF TNLG7C XCL2 PMC6214980__F7 Sex-associated function of epithelial STAT3 signaling in K-ras mutant lung cancer CXCL1 CCL2 ARG1 CCL1 STAT3 PMC8507033__F4 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining GDF5 TLR4 IRAK1 TRAF6 TCF7L2 STAT3 PMC5781259__F2 Construction and analysis of the HEV-host PPI network EIF4A2 EIF2S1 EIF4A1 EEF2K EIF5B GSPT2 EIF4EBP2 EIF4EBP3 EIF2B1 PAIP1 EIF2B5 EIF2B3 EEF1A1 EIF2B2 EEF1A2 EIF1AY EIF4EBP1 EIF1AX EIF2AK1 EIF2S2 EEF1G EIF5 EIF2S3 ETF1 PABPC1 EEF1B2 EIF4B PPL EEF2 EIF4G1 EIF2AK4 PMC8507033__F2 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining TSHZ3 HOXD10 EEF2 PTEN MTOR FOXO1 BAX PMC8507033__F3 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining IRAK1 TRAF6 TCF7L2 PTEN MTOR FOXO1 STAT3 PMC8102118__F6 Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy SMAD2 SMAD4 PMC11621219__F4 Immunostimulants regulating adaptive immune responses by activating TLRs IL10 TLR5 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 PMC12012963__F1 Simplified schematic of de novo nucleotide synthesis UMPS CAD DHODH HEL107 PMC5486142__F2 Adiponectin signal transduction implicating a cross talk with the insulin signaling pathway: Insulin and adiponectin interact with their respective receptors, which trigger a cascade of signaling events ADIPOR1 ADIPOR2 PTEN APPL1 PMC6360685__F2 The mechanism of miR-34 in EMT LEF1 DKFZp781B1423 TGFBR1 SMAD4 STAT3 PMC6534557__F5 Directed acyclic graph (DAG) of the 10 most enriched Gene Ontology (GO) terms and cytokine–cytokine receptor interaction pathways based on KEGG analysis AEN PMC5039587__F1 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells CD14 TLR4 FOS SIGIRR IRAK2 TRAF6 IRAK4 MYD88 JUN TAB3 MAL PMC4255921__F1 Canonical and non-canonical TGFB signaling SMAD2 DROSHA SMAD4 PMC5039587__F2 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells by acidic (APS) and neutral (NPS) exopolysaccharides produced by Lactobacillus plantarum N14 and Lactobacillus delbrueckii TUA4408L CD14 TLR4 FOS SIGIRR NPS IRAK2 TRAF6 IRAK4 JUN TAB3 MAL PMC3134613__F6 Specificity in neuronal activity-regulated gene transcription FOXO3A CLCA1 FOS BDNF EPHB2 PMC11186373__F8 Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12 SLC6A12 SGK1 GSDMD PMC3035094__F6 Cic regulatory elements mediate Torso and EGFR responses EGFR CIC TG PMC3285553__F3 Additional mechanisms by which Wnt/Beta-catenin signaling can be modulated in cancer HGF APC NOTCH1 SMO PMC3285553__F4 Schematic illustrating numerous small molecules and biological compounds identified in the literature that inhibit Wnt/Beta-catenin signaling at various points in the pathway SFRP4 DKK3 APC GSK3B FZD7 FZD8 PMC4878148__F1 Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer BRAF PDGFRA ERBB2 EGFR PTEN PMC6801973__F3 Entamoeba sulfolipid metabolism DIO1 SF1 PMC9641939__F6 Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock PLN HEL-S-11 PMC4231433__F1 Wired on sugar: the role of the CNS in the regulation of glucose homeostasis POMC AIP MC4R MTOR PMC11141639__F1 Winer et al PLK1 MYC JAK1 PMC5526760__F5 Summary of gene function and epistatic interaction of the IL-10/STAT3 signaling pathway in pediatric inflammatory bowel disease IL10 TYK2 JAK1 IL10RA IL10RB STAT3 PMC2674015__F2A Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases TBK1 TLR4 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TIRAP MAL PMC8050341__F3 Lactate and amino acid metabolism in Tregs AHR ARG2 GPT SLC5A12 CIT CD36 FOXP3 GLS PMC2657110__F2 HIV-1 modulates the interferon-induced antiviral host mechanisms, protein kinase R and 2',5'-oligoadenylate synthesis RNASEL ELF2 RNASE1 PMC8050341__F1 Mitochondria and fatty acid metabolism in Tregs ENO1 FABP5 ACLY FOXP3 PMC4825590__F1 Crosstalk between cell cycle regulators and cellular metabolism APC CCND1 CDK4 CDK6 PMC7609160__F1 Hippo Signal Transduction Mechanisms in T Cell Immunity APC GSK3B DOCK8 LRP5 LRP6 ARHA LATS1 LATS2 FOXO1 RAB13 PMC6177401__F4 Dengue virus and the host innate immune response TBK1 CGAS TLR7 IRF7 TRAF3 DROSHA TRAF6 IRF3 MYD88 TLR3 MAVS PMC6177401__F5 Dengue virus and the host innate immune response STAT1 HEL-S-62p C4B_2 STAT2 TYK2 UBR4 JAK1 C1S PMC6177401__F2 Innate immune response to DENV infection TBK1 CGAS TLR7 IRF7 TRAF3 DROSHA TRAF6 IRF3 MYD88 MAVS PMC4364715__F4 Novel Genetic Locus Implicated for HIV-1 Acquisition with Putative Regulatory Links to HIV Replication and Infectivity: A Genome-Wide Association Study BCL2 FRMPD1 PMC6177401__F3 Dengue virus and the host innate immune response STAT1 C9 TLR4 C4B_2 STAT2 IRF9 C6 TYK2 JAK1 PMC3597092__F3 Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR SULT2A1 FGF19 UGT2B4 BAAT CYP7A1 PMC3493824__F1 Cellular Targeting in Autoimmunity CD2 PMC3493824__F2 Cellular Targeting in Autoimmunity CCR5 CD22 CCR1 PMC2583357__F1 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY TSC2 BAD TSC1 FOS HEL-S-28 SRC PTEN EIF4E MTOR JUN RHEB RAI1 PMC2583357__F3 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY TSC1 CS PTEN PMC5839390__F6 NFAT-mediated defects in erythropoiesis cause anemia in Il2−/− mice EPOR EPO NFATC1 KLF1 PMC11354414__F3 Cell signaling pathway involving TNFA in activating NFKB TBK1 RIPK1 TNF MAP3K7IP1 PMC9685446__F9 Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis TG SIRT1 FASN PMC11546156__F1 Brief molecular mechanisms of the autophagy signaling pathway ULK1 ATG12 ATG3 ULK2 UVRAG ATG10 ATG14 DKFZp686F0183 PMC11718791__F1 PI3K pathway and FDA-approved, or fast-track designation-granted PI3K inhibitors TSC2 TSC1 PTEN PMC11718791__F2 PI3K, cell cycle, and ER pathways crosstalk in HR+ HER- BC TSC1 CCND1 CDK4 PTEN CDK6 PMC6785146__F3 Mechanism of alterations in the TSPO-mediated mitophagic signaling pathway and NLRP3 inflammasome activation in bipolar disorder PINK1 IL18 IL1B PBR STAT3 PMC8417405__F2 Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation TSC2 TSC1 IGF1 ATM MDM2 PTEN HRAS ATR PMC5183627__F1 TGR5 regulates different cell signaling pathways GSK3B ARHA RHO TRPA1 ITCH STAT3 PMC6908786__F4 Different signaling pathways triggered by different iNOS inducers that regulate iNOS expression (left: activation of NFKB pathway; right: activation of JAK/STAT-1A pathway) TLR4 TRAF6 MYD88 PMC5334258__F3 Trafficking pathways of E-cadherin NOSTRIN VPS35 SCRIB SNX1 PMC3782064__F2 Ingenuity pathway analysis CD99 ACACA TRAF3 COLEC12 HSF1 CEBPG FBXW7 MICA PGAM1 CCNK TRMT2A AATF ATXN3 ZNHIT3 SACS EXOSC1 ZGPAT TNFRSF19 PILRB CEBPA PILRA STAG1 SREK1 TCF2 RCOR1 FOXA2 PTPRC WNT3 TUBB4B HNRNPC TYMS GLDC NEK9 PMC7247259__F1 Biogenesis, structure, release, and uptake of exosomes CD63 CD2 PMC8933076__F1 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases CYP27A1 GCA CYP8B1 CYP7B1 CYP7A1 HSD3B7 PMC9068303__F8 N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway CCNB1 CCND1 MTOR STAT3 PMC8567988__F6 Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus ULK1 ATG12 DEPTOR ATG14 PMC9597993__F6 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy MTOR TGFB1 PMC6342515__F1 Therapeutic potential of NAD-boosting molecules: the in vivo evidence NAMPT NADK NOX4 NMNAT3 SLC36A4 SLC7A5 NAPRT SLC22A13 HEL-S-90n SLC5A8 NMNAT1 NMNAT2 SARM1 MAL PMC8933076__F3 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases CYP46A1 CCL2 PMC5755497__F10A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation PLK1 RPRM DKFZp781B1423 CHEK1 AURKA CHEK2 EP300 TRIP12 WEE1 ATM PPM1D MDM2 ATR C13orf34 PMC7725656__F2 Diverse ubiquitin codes in the regulation of inflammatory signaling RIPK1 TRADD CYLD ATF2 RELA SHARPIN TNF OTULIN TRAF2 PMC12128541__F8 Proposed mechanistic pathway for HDAC3 in mediating psoriasis CGAS HDAC3 TNF PMC3518543__F4 NFKB activation pathway is regulated by S-nitrosylation TLR4 SRC MYD88 TIRAP PMC4789422__F6 Module network of the core network biomarkers in to investigate the bladder carcinogenic mechanisms from stage 1 to stage 4 bladder cancer cells HEL-S-89n SUMO2 FOS HEL-S-99n BAG6 TNF HEL-S-125m UBC ECT2 GTF2A1 DNAJB11 HEL-S-269 FAF2 COPS5 ADRM1 C17orf95 KPNA2 PAAF1 JUN RPS20 TF PMC12087080__F2 miR-155 participates in multiple cellular functions VHL SMAD4 ARHA IL6 JAK1 STAT3 PMC4789422__F7 Carcinogenic mechanisms from normal to stage 1 bladder cancer cells (a), and from stage 1 to stage 4 bladder cancer cells (b) UBC SUMO2 PSMD12 ECT2 FAF2 HEL-S-99n DNAJB2 PSMD2 TNF RPS20 PMC12087080__F3 Mechanistic overview of miR-155 in regulating insulin signaling and glucose metabolism PDC TLR4 SOCS1 PMC5133817__F1 Argon’s molecular mechanism TLR4 IRAK4 MYD88 MTOR STAT3 BAX PMC3140053__F1 Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk IL10 COX2 CXCR4 IL6ST IL6 CXCL12 TNF STAT3 PMC8033157__F3 Immune evasion by coronaviruses TBK1 CGAS STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 ADAM17 RNASEL ISG15 RNASE1 TLR4 NF2 TYK2 ACE2 MAVS PMC9655478__F10 L-Citrulline Supplementation Restrains Ferritinophagy-Mediated Ferroptosis to Alleviate Iron Overload-Induced Thymus Oxidative Damage and Immune Dysfunction GPX4 HEL-S-44 IL1B PMC8033157__F1 Induction of type I IFNs in response to viral infections TBK1 CGAS TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 RNASEL TLR8 RNASE1 TLR4 INF2 MAVS PMC9596766__F1 Two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons MUTYH OGG1 TET1 PMC3616892__F6 MTOR in CD4+ T cell differentiation SOCS3 STAT4 SOCS5 GATA3 STAT3 FOXP3 PMC3535427__F1 Targeting 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) for colorectal cancer prevention and treatment LTA COX1 LTB PMC10873211__F9 Nasal Administration of bFGF-Loaded Nanoliposomes Attenuates Neuronal Injury and Cognitive Deficits in Mice with Vascular Dementia Induced by Repeated Cerebral Ischemia‒Reperfusion KEAP1 NQO1 BAX PMC7408653__F1 Wnt Signaling Pathway Activation and Inhibition APC GSK3B PMC9359433__F1 RET signaling pathway and RET inhibitors in human cancer DOK3 DOK4 DOK5 SHANK3 PSPN ARTN NRTN IRS1 GRB7 DOK1 RET FRS2 GRB2 SRC GDNF GRB10 GFRA3 GFRA2 STAT3 GFRA4 PMC9359433__F2 RET signaling pathway and RET inhibitors in human cancer RET STAT3 PMC9265429__F3 Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases TSC2 TSC1 KEAP1 DEPTOR RHEB MLST8 PMC7532973__F8 Schematic presentation of the mechanisms triggered by HAS3-induced EVs in target cells DHH EGF IHH CD44 HAS3 PMC3191937__F3 Local regulatory proteins that mediate some of the actions of TGFB in human myometrium and leiomyoma RUNX1 RUNX2 CTGF PMC3169542__F7 Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD IRF3 TLR3 MAVS PMC3466241__F7 Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway MAF KEAP1 PMC11915071__F3 Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies DOCK5 HAMP OXCT1 SMAD2 APC GSK3B SMAD4 ADAM10 FUS STAT3 PMC4816192__F1 Targeting of BCR and PI3K/AKT signaling as therapeutic strategy in CLL IGF1R BCR BASH LYN SYK PLCG2 MTOR ROR1 PMC6287618__F1 Role of EGF Receptor Signaling on Morphogenesis of Eyelid and Meibomian Glands MAP3K1 ASB1 EGFR FGF10 HBEGF ARHA TGFA PMC8472426__F6 HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells HEL-S-102 ELF2 ATF4 EIF2A XBP1 PMC6862663__F1 Gut dysbiosis/permeability increase circulating LPS and exosomal HMGB1, leading to TLR activation in microglia and the induction of iNOS and superoxide ASMT HMGB1 PDC AHR AANAT PMC8047311__F2 Pathogenesis of AAV and the inhibition of the binding of biological agents HEL-S-62p MPO CDS2 CD80 TNF PMC9206211__F2 Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis-Induced ALI/ARDS: New Research Progress and Prospect FGF21 MSC MTOR ARG1 SIRT1 STAT3 PMC2741134__F2 Inteferons pen the JAK-STAT pathway STAT2 IFNGR2 TYK2 IFNAR2 IFNAR1 IFNGR1 PMC8593085__F6 An In-Depth Review of Niraparib in Ovarian Cancer: Mechanism of Action, Clinical Efficacy and Future Directions TBK1 CGAS APC IRF3 SLC19A1 PMC4833639__F1 Many oncogenic mutations drive nutrient transporter gene expression ULK1 PI3 PAK1 RAC1 ARF6 AMT CD36 PMC3900493__F1 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTA ESAM LTB LTBR ELL PMC3900493__F2 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTA LTB CXCR5 CD40 LTBR ICOS PMC3900493__F3 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTA LTB LTBR PMC2723867__F1 Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses FYN PC BCR BASH APC LCK LYN ZAP70 PLCG2 RAC1 CDC42 CD19 PMC11853266__F4 Advanced glycation end products (AGEs) induced inflammatory cell signaling pathways ARHA RAC1 TIRAP CDC42 PMC11853266__F5 TLR4 signaling pathway in DPN TLR4 CYLD NOTCH1 MYD88 HES1 PMC7072649__F1 Pre-B cell leukemia (PBX3) is a target and a regulator of multiple signaling pathways HMGA2 SOX2 APC MMP9 MYC SALL2 TRIB2 IL6 PTEN FLT3 PBX3 PMC7867516__F7 Related mechanism responsible for isoflurane-induced proliferation of squamous cervical cancer cells MTOR PCNA PMC5553593__F7 Interaction network of lysine-succinylated proteins in D SET PMC6299239__F2 Tankyrase-mediated Wnt/Beta-catenin signalling APC RNF146 PMC12122448__F2 Biological processes and genes involved in the Apelin Adipocyte Signaling Pathway, significantly activated by the DOP diet GNA11 LIPE APLN HIF1A PMC9360879__F5 IL-13 alleviates idiopathic pulmonary hypertension by inhibiting the proliferation of pulmonary artery smooth muscle cells and regulating macrophage infiltration ING1 MRO MAL BOK PMC10968029__F1 Illustration of GRB2 in humans and other organisms, highlighting its role in signal transduction and depicting the subcellular localization of GRB2 GRB2 RAD51 PTEN MRE11A RBBP6 CBL PMC6348509__F1 Targeting LCSCs by suppression of autophagy and Nanog.Autophagy positively regulated LCSCs by suppressing p53 and favoring the activity of Nanog NUMB TLR4 HGF TWIST1 ABCG2 ABCB1 AURKA STAT3 CD24 PMC10610230__F7 Mechanism underlying the therapeutic effect of PT on IDD EDN1 FOS PTGS2 ACAN COL2A1 TNF JUN PMC10968029__F3 Diagrammatic portrayal of GRB2 splicing variants, particularly GRB3-3, in signal transduction HNRNPC GRB2 ADA PMC10968029__F4 Configuration of GRB2 in Protein Interaction and Signal Transduction GAB2 EGFR SRC MTOR IRS1 PRR14 CBL PMC8357504__F3 Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma BAK1 BMP2 POLK GLI3 GSK3B SMO DDB2 DVL3 BAX PMC12003390__F1 Crosstalk between benign non-immune cells and cancer cells PC LIF CXCR4 CXCL8 SRC CXCL12 STAT3 PMC5860944__F2 Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM) NF1 LIF EGFR PTEN PCNA PMC2946881__F1 Regulation of adipogenesis by canonical Wnt signaling cascade APC LRP5 PMC8842579__F3 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies TBK1 IFIT2 IFITM3 TRAF3 B4GALT5 TRAF6 IFITM1 ZBP1 IFNLR1 DNAJC6 RNASEL STAT1 SPATS2L CH25H LY6E TLR4 BCL10 FASN STAT2 ELF1 IRF9 IRF3 IFNAR2 IFNAR1 TLR3 IL10RB CARD9 SYK TYK2 JAK1 MAVS IFIT1 PMC8842579__F4 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies TBK1 STAT2 IRF9 TRAF3 IRF3 IFNAR2 MYD88 IFNAR1 STAT1 TLR4 SYK TYK2 JAK1 MAVS PMC9346148__F1 腺苷/A2AR信号通路阻断在肿瘤治疗中的应用 ADA ADK PMC6558049__F9 Possible mechanism of CAPE-pNO2 inhibits TNBC growth and metastasis EGF EGFR VEGFA CDH2 STAT3 PMC3999750__F4 PAR1 and PAR2 modulate TLR3-dependent expression of IFNB in CFs IRF3 TLR3 TF PMC11754051__F7 Interferon alpha production by the MAGUK-family protein CASK under H5N1 infection CCT4 HEL-S-94n TAF15 IRF7 CDK5 CASK TNK1 PMC8790852__F1 Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer PLCG1 HGF EGFR GRB2 CD44 SRC MTOR CRK STAT3 PMC7025585__F1 Bat cells mount an antiviral response to RNA viruses, but limit the expression of inflammatory cytokines NLRP3 TLR7 STAT2 RIGI IRF3 TNF MAVS PMC10564428__F8 Myeloid-specific knockout of SHP2 regulates PI3K/PLCG signaling pathway to protect against early myocardial infarction injury MERTK MYD88 TNF IFNG PMC4177028__F2 Intracellular energetic units (ICEUs) AK2 AK1 MAL CD36 PMC11721226__F2 TGFB/SMAD4 signaling pathway in immune cell; A The TGFB/SMAD4 signaling pathway promote the differentiation of naive CD4+ T cells into Th17 cells and regulatory T cells (Tregs) SMAD2 PMC7025585__F2 Exogenous and self-DNA sensing pathways are dampened in bat cells NLRP3 TLR9 STAT2 MNDA RIGI AIM2 PMC7330108__F2 Cancer cell death induced by Apoptin APAF1 CDK2 APC MMP9 BCL2 MTOR PMC3134994__F1 Schematic Illustration: TGF-beta signaling pathway SMAD2 SMAD4 PMC4542378__F1 Signaling networks activated during primary KSHV infection as analyzed by Kinex antibody array and IPA TRADD EGFR MDM2 GRB2 SRC TRAF2 IRS1 CEBPB INSR PMC3043627__F1 Simplified model for the intersection of signaling pathways regulating protein synthesis and degradation GSK3B EIF4E MTOR PMC2891946__F7 Crosstalks between EPCR, PAR-1, S1P1, and Tie2 TH PC ARHA RAC1 PMC6985208__F2 Signaling pathways associated with highly differentiated proteins in X spermatozoa HEL-S-49 COX2 HEL-S-278 UQCRC1 ACACB HEL-S-133P HEL-S-162eP PMC8091149__F6 Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function IL1A SCARB1 MAP2K4 IL17F RALA SAA1 TNF SERPINE2 RIPK1 PLAT RELA TIMP3 IL17RA COL6A1 ECSIT IL17C SELS JUN STAT3 INHBE PMC6985208__F3 Signaling pathways associated with highly differentiated proteins in Y spermatozoa GSTM3 PDHX DNAI2 CAPZB EFHC1 TUBA8 PMC7279580__F6 Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions EGF TIMP1 IGF1 IMPACT PGAM1 PMC1234333__F7 Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions DLX2 ELK3 AKAP12 RUNX1 SNAI2 SMAD4 ITGB6 ADAM19 SMURF1 SOX4 CITED2 HES1 GADD45B NET1 JUNB GATA3 PMC5322275__F3 Schematic model summarizing the findings of the proteomic and metabonomic profiling analyses DGCR8 TXNRD2 HIRA DLG2 BSN GSK3B GRIA3 CAMK2G RHO MTOR GRIA2 DLG4 VAMP2 TBX1 PMC10551897__F11 KEGG pathway diagram for PI3K-AKT signalling pathway TSC2 BAD BCR SYK PTEN IRS1 BRCA1 RBL2 CD19 PMC4727329__F7 MILP model identifies causal relationships from PI3K/AKT and TP53 pathways (KEGG) (a) PI3K/AKT pathway is altered in phase 1 of breast cancer progression; (b) TP53 pathway is altered in phase 2 of breast cancer progression IGF1 PIK3CA PTEN MTOR PMC10551897__F12 KEGG pathway diagram for EGFR tyrosine kinase inhibitor resistance pathway BRAF EGFR SHE PTEN PMC10551897__F13 KEGG pathway diagram for MAPK signalling pathway TH CD14 MAX TRADD GRB2 TRAF6 ECSIT TNF TRAF2 PMC4982440__F6 Proposed Model of PI3KA Resistance in SGK1-Expressing CellsPIK3CA-mutant breast tumors depend on the PI3K pathway, which mainly signals through AKT TSC2 SGK1 RHEB PMC4108926__F2 Melanoma and integrated Breast cancer pathway landscape ME1 ATM TES PMC2724002__F2 Controlling Hair Follicle Signaling Pathways through Polyubiquitination GLI3 SHH PMC2766659__F4 Signaling molecules and pathways regulating the fate of spermatogonial stem cells SMAD4 GDNF SRC LHX1 BMP4 PMC11506536__F2 Illustrates the multifaceted mechanisms of action of niclosamide in cancer treatment RICTOR APC GSK3B MTOR OTP RHEB STAT3 PMC9367165__F2 Twinkle twinkle brittle star: the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research POFUT1 NUMB MESP2 FURIN ACBD3 LNX2 HDAC1 NEDD4 PMC8086092__F12 Comparative transcriptomic analysis reveals the regulatory mechanism of the gibberellic acid pathway of Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.) dwarf mutants SKP1 GAL GAST PMC9212771__F6 In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19 HEL-S-62p BAD LIF SP1 OBI1 PMC6702832__F5 Modulation of the NFE2L2 pathway in keratinocytes MAF AHR SFN NFE2L2 PMC6263799__F1 Summary of the current model of the GET pathway GET3 GET1 GET4 PMC6702832__F6 Modulation of the NFE2L2 pathway in melanocytes MAF KEAP1 NFE2L2 MAPK1 PMC6702832__F7 The NFE2L2 pathway in fibroblasts MAF SFN NFE2L2 MAPK14 PMC2928959__F6 Hypothetical model for EGFR-dependent loss of cell polarity and activation of Wnt signaling in CS-exposed human airway epithelium MUC1 APC EGFR LRP5 LRP6 PMC5537818__F6 Underlying mechanisms of n-3 PUFAs protecting metabolic syndrome APOB LPL MYD88 TG PMC12040899__F10 SUMOylation and SAFB2 in PDAC Progression AHNAK2 SAFB2 PMC4871587__F3 Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis UTP11 AZI2 RRM1 FGF3 MYC GRB2 LFNG PLCG2 HAS2 PMC7082839__F7 Diverse APJ signaling pathways activated by prolonged mechanical load or apelin PLN MTOR RYR2 PMC3690588__F1 Wnt signaling APC RHO BCL9 PMC2790152__F3 A model of the inhibitor of growth (ING) 2 signaling pathway RBP1 SIRT1 PMC7082839__F4 AT1R signaling pathways activated by prolonged mechanical load or Ang II EGFR TRPC6 TRPC3 MTOR ATR PMC2671642__F5 Comprehensive genomic characterization defines human glioblastoma genes and core pathways PDGFRA CDKN2C DKFZp781B1423 EGFR PTEN RB1 CDKN2A CDK6 CCND2 NF1 CDKN2B ERBB2 MDM2 CDK4 PMC4881178__F7 Proposed pathway of ASPE signaling in MDA-MB-231 cells CDK2 CDK4 CDK6 BAX PMC5855681__F2 MicroRNAs regulate gene transcription AGO1 DGCR8 DROSHA YY1 EZH2 SUZ12 PMC3294426__F3A Into the Eye of the Cytokine Storm SOCS2 SOCS3 IRAK1 MAPK14 MYD88 MAP2K6 ORM1 C9 FGA IL1A MAP3K1 HRG TNIK SOS2 MAP3K7 MAP3K5 TNF HRAS SHC2 MAPK13 TNFRSF13B ORM2 TNFRSF8 TNFRSF18 GRB2 RBP2 SHC4 ITIH3 APOH TNFRSF17 SAA2 NFKBIE RBP1 TRADD TNFRSF13C SHC3 CEBPB ITIH2 RIPK1 SOCS4 SOCS7 PTPN11 ECSIT C1S APOA2 JUN CFB TNFRSF19 MAP3K7IP1 NFKBIB MAP2K1 HP LBP AHSG SOS1 TCF4 STAT3 PMC4081675__F1 Signaling pathways regulating hepatic stellate cell activation in alcoholic liver disease TLR4 SMAD2 SMAD4 BCL2 PMC1447421__F10 Hypothetical model describing the roles of Rad18 and PolK in the BPDE-induced S-phase checkpoint ATM POLK ATR RAD18 PCNA PMC7379175__F8 Model depicting the relationship between CIBZ, RB1CC1 and autophagy ULK1 ATG101 RB1CC1 PMC7477886__F3 Simulated network from genetic variant to disease constructed from the insulin signaling pathway from KEGG TSC2 BAD TSC1 PDK2 GSK3B GRB2 EIF4E MTOR FOXO1 RHEB INSR PMC7477886__F4 Whole network from APOE genotype to AD constructed from KEGG-based Alzheimer’s disease pathway ITPR2 BACE1 PLCB3 BAD RTN3 CACNA1C CASP3 TNFRSF1A CASP9 ADAM10 CASP8 FADD CYCS APOE PMC2904682__F1 Schematic model of regulatory pathways involved in Mycn stabilization PIN1 RICTOR IGF1R ALK PDK2 GSK3A CDC2 MTOR PMC7407487__F4 Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney CASR DCT WNK4 PMC11706183__F8 Uncovering iron imbalance and inositol metabolism disruption: insights from the yeast model of N88S seipinopathy PIN1 PC INS PMC2883240__F1 Signaling pathways involving molecular markers for human breast cancer FOS TBX2 TBX3 DMP1 BRCA1 ATM BRCA2 DHFR MDM2 CCND1 CDK4 ATR JUN PCNA PMC2453756__F1 Pathway of murine Th17 differentiation TH IL25 FOXP3 PMC7569249__F5 Overexpression of Rab40b promotes hepatocellular carcinoma cell proliferation and metastasis by upregulating cyclin D1, cyclin E1 and MMP2 via PI3K/AKT signaling pathway RAB40B MMP2 CCND1 CCNE1 PMC2897739__F1 Recent advances in the genetics of systemic lupus erythematosus UBE2L3 TLR9 FCGR2A IRF7 IRF8 TRAF6 IFNAR2 TNLG2B IFNAR1 DKFZp686F0183 IFNG STAT1 ITGAM IKZF1 LYN TYK2 JAK1 TNFAIP3 NCF2 PMC2752361__F3 MOLECULAR CONSTITUTION OF BREAST BUT NOT OTHER REPRODUCTIVE TISSUES IS RICH IN GROWTH PROMOTING MOLECULES VAV3 IGF1 GHR FOSB WT1 CRK JUN TUSC3 FGF9 PMC5557856__F6 Proposed mechanism by which CoQ10H2 improves metabolic function and inhibits insulin resistance in KKAy mice NR1C1 SIRT1 PMC7140893__F6 Gene–gene interaction (GGI) and protein–protein interaction (PPI) predicted networks of DEGs enriched in the extracellular exosome post heat stress TUBA4A HSP90AB1 ICAM2 POSTN ALB A1BG CNDP2 DOCK10 DNAJB1 GNG10 SERP1 AMBP ITIH4 S100A6 IGFALS HEL-S-78p opn CD55 KNG1 S100A4 APOA2 PTGES3 CD14 FGA GNA13 THY1 HEL-S-102 SIRPA AHSG HEL113 APOH DOCK2 LAT TGFBI PMC8939180__F4 Metabolome and transcriptome analyses identify the plant immunity systems that facilitate sesquiterpene and lignan biosynthesis in Syringa pinnatifolia Hemsl. MVD MVK CAD IPP PMC6523117__F7 Suggested mechanism of rFlaA:Betv1-mediated mDC activation TLR5 IRAK1 TRAF6 IRAK4 MYD88 MTOR STAT3 PMC9688731__F3 Extracellular Vesicles in Multiple Myeloma—Cracking the Code to a Better Understanding of the Disease RUNX2 AREG CXCR4 MSC MMP9 EGFR PMC6563125__F8 Model of interaction between an oncolytic virus and the host type I IFN response and cyclin expression STAT1 OAS1 CDK2 IRF9 PMC7825104__F3 Adrenergic signalling pathway and mechanisms BAD BRAF SNAI2 LATS1 HIF1A MTOR STAT3 PMC2713319__F1 Apoptosis and Epithelial Injury in the Lungs FADD PMC1522081__F7 Involvement of MACF1 in the Wnt/Beta-catenin signaling pathway APC GSK3B PMC2713319__F3 Apoptosis and Epithelial Injury in the Lungs CD14 TLR4 MYD88 IL1B FADD PMC7217787__F1 Rapamycin use in COVID-19 TH CD2 CD44 MTOR ACE2 MAVS PMC8053758__F4 Promising targets for therapy of osteoarthritis: a review on the Wnt and TGFB signalling pathways SIRT1 FOXO1 CLK2 PMC3753498__F9 Schematic representation of methionine metabolism via methionine cycle and transsulfuration pathway showing cysteine as a precursor of GSH and hydrogen sulfide (H2S) HEL-S-61p PMC5850680__F1 Under the action of BMP2 and inflammatory mediators such as tumor necrosis factor, the expression of transcription factors Runx2 and osterix can be activated via the BMP/Smad pathway LRP3 RUNX2 BMP2 CRP LRP6 MSX2 TNF PMC5913738__F2 Intermittent metabolic switching, neuroplasticity and brain health ULK1 NRF1 MTOR BDNF TFAM SIRT3 PMC5913738__F3 Intermittent metabolic switching, neuroplasticity and brain health FGF2 MTOR BDNF SIRT1 SIRT3 PMC11534336__F1 Schematic models of the core of MAPK/ERK pathway and human eIF3 complex TSC2 EEF2K PAK1 TSC1 ELF3 GRB2 CCND1 RHEB PMC2634257__F1 Simplified schemes of the three Wnt signaling cascades DAAM1 LEF1 RHO PMC3111485__F5 A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1 FOS GAB2 PMC5306369__F1 Complement activation and evasion by NS1 protein of flavivirus HEL-S-62p C9 C4B_2 MNS1 C7 C6 C1S C4A PMC10198710__F2 m6A methylases that participate in cancer glycolytic metabolic pathways METTL14 YTHDF1 BPTF METTL3 ENO2 ALKBH5 WTAP PDK4 HK2 PMC5774705__F3 Hybrid genome assembly and annotation of Paenibacillus pasadenensis strain R16 reveals insights on endophytic life style and antifungal activity FER RERE PMC9563266__F2 MARCKS in Metastasis and Treatment Resistance of Solid Tumors MARCKS SOX2 ERBB2 MMP9 ARHA PTEN ABCB1 PMC3315682__F1 Serine biosynthetic pathway PSAT1 PSPH PHGDH PMC4282831__F3 Seeing through VEGF: Innate and adaptive immunity in pathologic angiogenesis in the eye HEL-S-62p SEMA3A CFB NRP1 CD55 IL1B PMC10198710__F3 m6A methylases that participate in ferroptosis YTHDF2 GPX4 SLC7A11 TFRC ALKBH5 IGF2BP2 SLC38A1 TIAM1 YTHDF1 METTL14 METTL3 YTHDC2 SLC3A2 TF PMC4339613__F3 Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment MAF KEAP1 VHL PMC1866211__F1 Hedgehog signalling pathway REN SPOP PMC6092617__F7 Targeting prohibitins at the cell surface prevents Th17‐mediated autoimmunity IL17A PHB2 FOXP3 PMC5727329__F2 DKK1 regulation of signalling pathways CKAP4 APC LRP5 LRP6 ARHA RYK DKK1 PMC5823660__F3 An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice CANX ATF4 HEL-S-99n BCL2 TRAF2 XBP1 PMC8838622__F1 An Emerging Role of Defective Copper Metabolism in Heart Disease ATP7B ATP7A ATOX1 HEL-S-44 CP PMC8472298__F2 Insulin and Insulin Resistance in Alzheimer’s Disease MTOR IRS1 PMC10907440__F2 Positive effects of SGK1 in embryogenesis VEGFA BMP7 SGK1 PMC2865489__F1 The estradiol-synthetic pathway and nuclear receptors CYP11A1 PBR STAR PMC2788159__F1 Regulation of mTORC1 mTORC1 is a multiprotein complex composed of Raptor, mLST8, PRAS40, and FKBP38 and regulates protein synthesis and cell growth by phosphorylating S6K1 and 4EBP1 TSC2 TSC1 EIF4E MTOR RHEB PMC8403639__F1 NRF2 signaling pathway MAF GCLM KEAP1 GCLC NQO1 PMC2788159__F2 Current proposed mechanisms of amino acid sensing by mTORC1 Amino acids are imported into the cells via various amino acid transporters and activate mTORC1 either by amino acid metabolites or by undefined membrane/intracellular amino acid sensor(s) TSC2 TSC1 RHEB PMC4303015__F2 microRNA-21 Mediates Stretch-Induced Osteogenic Differentiation in Human Periodontal Ligament Stem Cells ACVRL1 PITX2 ACVR1C TGFBR2 LTBP1 BMPR2 ACVR2B SMURF2 BMP8A THBS1 ZFYVE16 DKFZp781O1323 TDP1 PMC6506819__F3 Disease-Associated Genetic Variation in Human Mitochondrial Protein Import NDUFB10 YME1L1 OMA1 PMC11781172__F1 Novel representative therapeutic targets for SCLC CD47 TIGIT DLL3 LAG3 AURKA PMC7851145__F1 LPA intra- and extracellular biosynthesis and degradation PC PLD2 LPA PMC9578258__F2 Synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment PALB2 SSB PARP1 DDB2 CDC25B DDB1 BRCA1 WEE1 ATM BRCA2 CDK2 TOPBP1 SMARCAL1 RAD51 XPA CDC2 ETAA1 ATR PMC5294251__F7 Proposed model for the CD271 regulation and potential downstream effects mediating drug resistance and metastasis NGF ATM MDC1 NEK2 FGF13 RAD51AP1 ATR H2AX TOP2A PRKDC PMC8270677__F4 Replication Stress Response on a Narrow Path Between Genomic Instability and Inflammation TREX1 RAD51 MRE11A PMC5381059__F1 Cancer immunotherapies targeting the PD-1 signaling pathway APC CD40 ICOS PMC7125293__F4 Transcriptome analysis on fructose as the sole carbon source enhancing perylenequinones production of endophytic fungus Shiraia sp. Slf14 ADA HEL107 COCH DLAT PMC8422427__F6 Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications ATF4 EIF2A TRAF2 XBP1 IL1B PMC10902513__F2 TGFB/Smad signaling pathway involved in radiation skin fibrosis SMURF2 SMAD4 PMC8578301__F1 Clinical and biochemical footprints of inherited metabolic diseases. VI. Metabolic dermatoses. SPTLC1 ALOXE3 SLC27A4 PHGDH ELOVL1 ELOVL4 UGCG PSAT1 ELOVL3 CERS3 PSPH SPTLC2 SPTLC3 ALOX12B SDR9C7 KDSR CYP4F22 PMC8648894__F1 Signaling in the crowded cell TTI1 MMD SLC38A9 EGFR GRB2 CA3 PTEN RAC1 MTOR DEPTOR RHEB PMC5652738__F9 Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer HGF EGFR STAT3 PMC7403652__F4 KEGG pathway with significantly enriched differentially expressed proteins ME1 AIFM2 BAD PERP ATM PGR BAGE CDK2 PTEN SIVA1 RFWD2 PMC4600925__F4 SGK1-mediated signaling pathway WNK1 PDK2 SGK1 PMC3289952__F1 Selected essential fatty acids molecular mechanisms ABCG1 ABCA9 ABCA1 PMC9387202__F10 The gut microbiota and lipidomic profiles by black chokeberry (Aronia melanocarpa L.) polyphenols via the glycerophospholipid metabolism signaling pathway PC PLD2 LPCAT2 PMC10561294__F7 Construction of PPI networks MMP3 BCL2A1 CSF3 CCL20 CXCL3 CXCL2 TNF PMC3289952__F2 Proposed role of essential fatty acids in “micromanaging” molecular actions AGO2 DGCR8 CDKN1B DROSHA GPR32 PTEN CEBPB PMC6437734__F6 VPA induces apoptosis in neutrophils and diminishes their phagocytic capacity FPR2 BAX PMC6437734__F8 VPA affects IL-12-, IL-15-, and IL-18-mediated IFNG production in NK cells STAT4 JAK3 MYD88 IFNG PMC6008067__F5 Proximity of Bcl-xl to p38, MK2, and RTN4 in platelet function POR MAP2K6 STAT5B STAT1 FYN APP HEL-S-44 LIMK1 STAT2 RTN4 HEL-S-47e TNPO1 ARHA HNRNPA0 HEL-S-21 ARPC5 MAPK15 HEL-S-102 TSC2 AGO2 BAG2 HEL-S-93 PNP AKT3 STAT3 PMC1592643__F3 An altered balance of proapoptotic and antiapoptotic molecules in trauma patients' T cells could indicate specifically increased vulnerability to apoptotic depletion TNFRSF25 DAPK2 BAD CD27 APAF1 ROCK1 CAD TNF DIABLO HTRA2 FAF1 GAS2 PMC7232489__F2 Bifurcated pathway to synthesize hexanoic acid in M HBD ACAT2 PMC6172370__F8 P38 MAPK signaling pathway in the regulation of the NLRP3 inflammasome and macrophage pyroptosis NLRP3 IL1B PMC4908728__F8 Schematic showing the effects of RBE on LPS-activated microglia IL10 TLR4 MYD88 IL1B PMC6862352__F1 Hh in the ischemic skeletal muscle DHH IHH SHH PMC11077380__F2 Mechanism diagram illustrates the crosstalk between Se-AA metabolism and various cell types in the TME HLA-E GPX3 GPX1 PMC10740873__F2 Ihh signaling pathway in regulating osteoblast differentiation (refer to Pan et al IHH RUNX2 PTCH1 GLI3 SMO SOX9 PMC11077380__F3 Antitumor application of Se-AAs ULBP2 MICB SMAD2 SSB BCL2 MICA PMC3733582__F3 Pathway Linker Results for AChE and BChE LAMA1 LAMB1 COLQ APP HAND1 ACHE BCHE COL4A1 PMC3830643__F2 Lipid Synthesis in Protozoan Parasites: a Comparison Between Kinetoplastids and Apicomplexans ELOC ELOA DES PMC9284119__F5 Overexpression of TwSQS, TwSE, and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells DDC POR IPP PMC6010849__F10 Schematic overview of Nrf2 signalling crosstalk to both Wnt3a/B‐catenin and AMPK pathway in COPD/emphysema WNT3A NQO1 PMC2652645__F1A Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning CD14 TLR4 RP1 IRAK1 TRAF6 IRAK4 MYD88 TNF MAL PMC11048799__F5 Mechanism by which GAA promotes muscle development and growth through mirNA-targeted gene regulatory signaling pathway [27,43,44,47,48,49,50,51] PDGFD PDGFA IGF2 EIF4E HRAS MTOR GAA PMC5983927__F7 Antitumor effects of corilagin FADD BAX PMC7817854__F2 miRNAs targeting SMO oncogenic hedgehog pathway to induce apoptosis in CRC DHH IHH EVC2 EVC SHH SMO PMC7261959__F12 Alterations induced on SIRT1/PGC-1A pathway by ABOs MFN1 NRF1 TFAM SIRT1 PMC6437734__F1 VPA inhibits LPS signaling in macrophages CD14 MDM2 TRAF6 IRAK4 PTEN MYD88 TAB3 PMC6741997__F8 Model of the neuronal death pathway involving Cdks CDK2 CDK5 HEL-S-44 CDK4 CDK6 PMC6437734__F2 VPA induces M1-M2 polarization of macrophages in response to LPS CD40 CD80 PMC6437734__F4 VPA inhibits monocyte to DC cell differentiation CD83 CD80 IL4 IRF4 STAT3 PMC9106028__F1 Front-Line Therapy for Metastatic Renal Cell Carcinoma: A Perspective on the Current Algorithm and Future Directions APC CTLA4 MTOR AXL PMC9343600__F11 Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice RUNX2 BMP2 DPP4 GIP IL6 STAT3 PMC7235440__F1 Herpesvirus host shutoff-associated proteins mediate evasion of the type I IFN signaling pathway (refer to ) TBK1 CGAS TLR9 STAT2 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS IFI16 PMC9641750__F6 Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate IL10 ACE2 PMC8123313__F1 Leptin Receptor Compound Heterozygosity in Humans and Animal Models POMC SOCS3 GRB2 FOXO1 STAT3 PMC8196557__F6 miRNAs and Genes Involved in the Interplay between Ocular Hypertension and Primary Open-Angle Glaucoma. Oxidative Stress, Inflammation, and Apoptosis Networks ATF7 FBN2 PTGFR FBLN2 BCL2L13 PAX2 BBS2 TDRD7 FBN1 DAP FOXE3 POMT1 SIX1 RB1 MMP21 SIX6 MMP17 CRYAA IFT46 SSNA1 COL11A2 ATOH7 IFT74 MMP2 BCLAF1 APAF1 ANGPT4 CRYBB2 RPGRIP1 CASP9 MSRB3 TACC1 DCC IRF-1 OPA1 ITGB3 TP63 DIABLO COCH BCL2 TGFB1 CD36 MAP2 DKFZp781B1423 COL1A1 FOXC1 XAF1 LTBP2 WDR36 THBS1 MYOC CYP1B1 CYP11A1 C3AR1 COL4A3 KALRN C6 COL4A2 TGFBI SPARC GPX4 MMP11 TRAF3 ITGB6 TPO BCL2L1 ITGA2 DCN MDM2 TGFBR3 VEGFA LAMB2 MYO9B COL5A2 TNC MMP14 ARC ITGAV LOXL1 CDC42 HEL-S-62p PXDN CASP2 OPTN SERPINC1 GPC1 F2 COL1A2 GDNF CAV2 XB IL6 GAS2 CASP3 BBC3 SLC23A2 TRAF3IP1 TP53AIP1 MAPKAPK3 PRSS56 MAPK8IP1 IFT81 COL8A2 COL4A5 APPL1 PMC9293517__F5 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis TH PRSS1 PGR GSTM1 KCNMA1 ACHE PTGS1 CHEK1 CYP1A2 INSR HEL-S-22 RXRA CHRM3 F2 CDK2 PTPN1 CHRM1 GABRA2 CHRM2 JUN SELE PMC3319358__F2 Gut triglyceride production DGAT1 DGAT2 BLM DKFZp434B2017 TG VAMP7 MGAT2 ACAT2 PMC2668982__F2 CCN1 signaling and crosstalk with TNFA CYR61 TRADD RAC1 CASP10 TRAF2 CASP8 FADD BAX PMC6355473__F4 New targeted therapies in advanced primary cutaneous anaplastic large cell lymphoma AK2 ALK AK3 CD2 NOTCH1 AK1 STAT3 PMC7563957__F1 Simplified diagram of the 5-fluorouracil (5FU) conversion system RRM1 RRM2 TYMS TYMP NT5E TK1 PMC3319358__F1 Gut triglyceride production HMFN0839 DGAT1 GPAT4 DGAT2 BLM PMC6848764__F2 Working model for CILK1 signalling SUFU GLI3 GSK3B SMO DEPTOR OFD1 IFT20 MLST8 PMC6348090__F10 Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma ATM CDK2 MDM2 CDK4 PIGS PTEN MTOR ATR CDK6 PMC6607389__F3 Protein-protein interaction network complex and modular analysis FLNA B3GNT6 FOXQ1 CXCL3 CCL5 CDKN2A FAT10 NOS2 CXCL11 CCL4L2 REG1B Meflin ACTG2 CES1 AQP1 CRABP2 CHP2 PRSS8 CXCL10 OLFM4 MXRA8 COL8A1 SPARCL1 FREM1 PIGR THBS4 CES3 REG3A ARHGEF25 HTRA3 AGPAT5 HTRA1 NTSR1 EDN1 SLC14A1 GGT7 FADS2 HLA-DRB5 DEFA6 REG4 DEFA5 C6orf15 SYT7 COL9A3 TNFRSF10A MUC20 DHRS12 SYNM ST6GALNAC1 MOGAT3 FHL1 HSPB7 CXCL1 LMOD1 CALB2 GNLY CTSF ANXA9 HEL-S-101 PTK7 TNNC1 TNNC2 DES ASPN MAPRE3 MEGF6 NKD2 CST2 FSTL3 CST1 PDLIM4 GBP1 CACNG4 HEL-S-90n CYB5B SLC12A2 FOXA1 PPP1R14A LRRC26 DSG3 KISS1 RBP4 IGLL5 MFAP4 MFAP2 FOLR1 RAMP1 MGP IHH ITLN1 TSC22D3 MUC5B LTBP1 SERPINE2 SYT1 TAGLN MLXIPL RGCC HEL164 TYMS GBP4 MAGEA6 MMP11 DKK1 HSPB8 SLPI TNFRSF11A CD74 VIP PRELP ATOH1 SERPINA1 CCL25 HEL-117 S100A4 SFRP4 PPL FOS CCL4 CDKN1C PLN MMP14 TIMP1 HEL-S-273 CXCL9 HEL-75 MSLN TNS1 COMP pp6425 MYLK COL10A1 PDX1 EMILIN1 ACTA2 EEF1A2 HEL-S-14 CDCA2 LGR6 NKD1 GNG4 GPC1 GZMA SULT2B1 FNDC1 IL1B BMP7 CXCL2 IDO1 HEL-S-102 PMC3362922__F1 Hexosamine biosynthetic pathway and its dependent processes PGM3 OGT SF1 SMS PMC3281607__F2 Antioxidant roles of Prx I, Prx III, and Srx in ethanol-fed mouse liver KEAP1 PRX CYP2E1 PMC6219086__F5 DE genes on “Wnt Signaling Pathway and Pluripotency” pathway upon S PRKCZ PRKCE MYC NKD2 NKD1 PRKCA MMP7 CRP AXIN2 ZBTB33 PPP2R2A JUN NFYA PPP2R3A PRKCI PPP2R2D TCF3 SOX2 PAFAH1B1 MAPK10 APC MAP3K7 TCF7L2 ARHA PRKD1 DVL1 CREBBP EP300 PRKCB CTNND1 NR1C2 FRAT1 PRKCH PMC12183286__F2 TREM2 signaling pathway (by Figdraw) DOK3 SOS2 LAT2 VAV1 RAC1 MYD88 ADAM17 LCP2 VAV3 TLR4 PC BIN1 GRB2 SRC SYK ADAM10 ddo SOS1 CD2AP LAT VAV2 CDC42 PMC6219086__F6 Insulin signaling pathway MAPK9 SOCS3 MAP3K11 CAP1 MAPK8 MAPK3 GSK3B MAPK14 FLOT1 MAPK1 PRKCI MAP3K1 PRKCQ SOS2 MAPK7 MAPK10 MAP3K7 RRAD MAP2K5 IRS1 SNAP23 RHEB TSC2 SHC2 GYS2 PPP1CC TSC1 VAMP2 MAPK13 MAP3K14 MAPK11 PRKCH CBLC GYG1 MAP2K3 XBP1 MAP4K3 INPP4A INPPL1 GRB14 MAP3K6 STXBP3 STXBP4 EHD1 STXBP1 EHD2 KIF3A RAB4A MAP3K10 MAP3K13 RAC1 MAP3K12 SNAP25 TBC1D4 ARF1 PIK3C2G PTPRF FLOT2 CBL IKBKB MAP4K2 MINK1 LIPE SGK2 MAPK6 MAPK4 MAP3K2 HEL-S-42 SHC1 PIK3CD PRKCZ TRIB3 PRKAA1 MAP2K6 PDPK1 PRKCA MAPK12 RAPGEF1 FOS EIF4E CRK HEL-S-31 GRB2 ENPP1 MAP2K4 MYO1C PTEN PFKM EIF4EBP1 SHC3 MAP4K1 INSR PTPN1 PTPN11 JUN IRS4 EGR1 PRKAA2 GSK3A GYS1 PFKL PIK3CA MAP3K8 RAF1 GRB10 SOS1 ARF6 SOCS1 PMC8165772__F7 Whole-genome resequencing provides insights into the population structure and domestication signatures of ducks in eastern China ENPP1 GRB2 SHE PMC7028855__F2 miR212 and Hedgehog pathway KIF7 SUFU PTCH1 GLI3 SHH SMO PMC10537781__F9 African swine fever virus I10L protein inhibits the NFKB signaling pathway by targeting IKKB TRADD IRAK1 TRAF6 MYD88 MAP3K7IP1 TRAF2 TRAF4 PMC8687399__F8 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy NLK APC LRP5 BCL2 DKK1 PMC4159616__F1 Bile Acids, Obesity, and the Metabolic Syndrome CYP27A1 GCA CYP8B1 CYP7B1 PMC8070467__F2 Metabolic link between diabetes and cancer EGF IGF1 MTOR PMC8687399__F6 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy NLK APC LRP5 LRP6 PMC8687399__F7 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy CASP3 CASP12 APAF1 CASP9 BCL2 TRAF2 BAX PMC8038768__F8 Overview of this study HGF GRB2 SIPA1 PMC7933006__F2 Reduced Tdo2 expression leads to reduced Trp flux through the kynurenine pathway (KP) SLC7A5 INMT TPH1 HEL-S-90n KYNU DDC TDO2 PMC6908615__F8 Illustration on the possible underlying pharmacological mechanism of neurotrophic activity of SCH in cultured hippocampal neurons OXCT1 PREB HNRNPH1 STX1A PMC3687624__F1 Simplified view of the canonical Wnt signaling pathway (Modified from ref APC SOST GSK3B LRP5 LRP6 PMC6610485__F2 Mechanisms by which bacteria influence cancer development and progression TIGIT STAT3 PMC11937519__F4 Schematic overview of the proposed BDNF-TrkB-FRS3 signaling pathway, its role in energy balance regulation, and its connection to the leptin-melanocortin pathway POMC AgRP MC4R PCSK1 LEPR FRS3 BDNF PMC9653759__F1 Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability CGAS IRF3 BAX PMC8633656__F1 Interleukin-17 family members in health and disease EBP TRAF6 SYK CD93 IL17RB IL17RC PMC6212405__F7 Distribution of the targets of Shenzhu Capsule on the compressed TNF signaling pathway CASP3 FOS HEL-S-11 LIF TEF DAP TRAF2 MLKL ITCH PMC12115679__F4 Critical signaling pathways regulating TILs infiltration, proliferation, and anti-tumor response GPX4 BST2 CXCL10 IL8RB TIGIT IFNG FOXP3 PMC5611503__F9 Signalling pathway of cytokine-cytokine receptor interaction signalling pathway EPOR EGF EPO CCR3 EGFR AMH IL22 IL2 ACTR2 KIT CCR4 LTB TRO IL24 TNLG7C TSLP EDAR LEP LTA CXCR4 GH1 IL20 OSM MPL SP3 LTBR PMC6346075__F1 Transsulfuration pathway pcap PMC8700948__F1 Regulatory Effects and the Signaling Pathways of Natural Bioactive Compounds on Ferroptosis GPX4 LPCAT3 FACL4 ADA TFRC SLC3A2 PMC8217106__F4 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives LEF1 APC TCF4 PMC8217106__F1 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives APC GSK3B LRP5 LRP6 BCL9 PMC3376449__F1 HER2 signaling pathway SRC PTEN CR2 MTOR CR1 STAT3 PMC7450153__F1 CGAS-STING DNA sensing signaling pathway TBK1 IRF3 IL6 TNF PMC9318283__F9 Protective Effect of Eurotium cristatum Fermented Loose Dark Tea and Eurotium cristatum Particle on MAPK and PXR/AhR Signaling Pathways Induced by Electronic Cigarette Exposure in Mice AHR IL6 PMC7450153__F3 Protumor role of the cGAS-STING signaling pathway CCR2 NFKB1 MSC PMC7205036__F11 Scheme summarizing the mechanism of the protective effect of astragalin and CGA on E CD14 IRAK1 IRAK2 TRAF6 IRAK4 CGA MYD88 IL1B PMC3704221__F1 miRNA biogenesis pathway AGO1 AGO2 DGCR8 AGO4 DROSHA CCR4 PMC8782480__F4 IPA canonical pathway, “Interferon signalling” IRF9 PIAS1 GIP IRF-1 PSMB8 SOCS1 IFNG BAX PMC12059070__F7 Gemcitabine-induced cellular responses POLD4 POLD2 CCNA2 PCLAF RPA3 FBXO5 RPA1 PARP1 RB1 CHEK1 DTL TK1 RRM1 RRM2 CCNB2 CCNB1 CDC2 ATR GMNN SLBP PMC5711269__F1 Reverse cholesterol transport pathway ABCG1 LDLR ABCA1 PMC3534848__F8 A proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and NO• generation in PAH CYP11B2 TET1 PMC4244643__F1 Biosynthesis of Isoprenoid building blocks IDI2 MVK IDI1 PMC4764764__F4 Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development NOTCH4 EPCAM TNFAIP6 ERG EFNB2 JAG2 KLF5 NOTCH3 EDN1 HEY2 F5 F3 HEL113 TGFB1 PMC6214770__F7 Proposed signaling model of crosstalk between NIS and PTEN signaling pathway ARHA PTEN MTOR PMC12070570__F8 Schematic overviews of signaling pathways of enriched hypomethylated mRNAs in LMCI/Control NPB BAD SET ALK ABO APOC1 APOD MCU TG LPL ADA APP COMP FADD PBR CD36 PMC7835216__F2 Emerging functions of branched ubiquitin chains UBR5 APC TXNIP ITCH PMC3785049__F3 Type I interferon induction is inhibited by paramyxovirus interferon-antagonist proteins at multiple stages TBK1 TRAF3 TRAF6 IRF3 TRAF2 TLR3 PMC3737169__F2 MTX cellular pathway GGH MTR ADSL DHFR TYMS AMPD1 HEL-S-70p FPGS ADK PMC9637033__F2 miRNAs: The Key Regulator of COVID-19 Disease DROSHA ACE2 TMPRSS2 PMC11752968__F2 Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases ATF4 TRAF2 XBP1 PMC4372648__F1 Three core signaling pathways altered in malignant gliomas NF1 PDGFRA CDKN2B DKFZp781B1423 CDKN2C EGFR MDM2 CDK4 PTEN CDKN2A CDK6 CCND2 PMC7595309__F2 Dual-function quorum-sensing systems in bacterial pathogens and symbionts CASR SYP CP PMC5754225__F1 PI3K-AKT-mTOR signaling pathways in glioblastoma TSC2 RICTOR TSC1 PTEN RPS6 MTOR IRS1 SGK1 RHEB PMC3776238__F2 Wnt regulation of larval NMJ differentiation DKFZp666G145 FZD2 PMC6177712__F2 Schematic depiction of cannabinoid and exemplar mono‐, sesqui‐, and diterpenoid biosynthesis STS IPP PMC7990354__F1 Molecular mechanisms of renal aging APC GSK3B LRP5 LRP6 IL1B ROS1 PMC2954189__F1 Simplified scheme of the double-edged role of Akt in tumor development TSC2 BAD CDK2 MDM2 CASP9 MTOR PMC11767460__F7 Association Analysis of the Genomic and Functional Characteristics of Halotolerant Glutamicibacter endophyticus J2-5-19 from the Rhizosphere of Suaeda salsa PROC IMP3 SORD TPP1 PMC7461309__F1 Pollen-induced activation of the innate immune system and Th2 polarization CXCL13 TLR4 IL33 CCL17 CXCR5 IL25 TNF CCL22 TSLP IRF4 GATA3 PMC4841025__F5 Insulin signaling pathway PTPRT FBP2 SOCS3 PCK1 SOST GCK PYGB TRIP10 CRK PTPRF CBL TSC2 CCK ARHG LIPE PPARGC1A CRB2 PMC4841025__F6 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice RARA SCD NR1C2 PPARG NR1C1 KERA RXRA PMC4841025__F7 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice CHUK PRKCE SOCS3 PRKAA1 TNF MTOR NR1C1 PRKCA LEP ACACB TEF TRAF2 STAT3 PMC7059166__F2 Canonical Wnt/B‐catenin(WBC) signalling pathway LEF1 APC GSK3B LRP5 LRP6 GPR49 LGR6 PMC6483058__F4 Visualization of resulting networks from Min-cut on the pathway of AD BACE1 PLCB3 BAD COX1 PPP3CA MAPK3 GSK3B HSD17B10 COX5A ADAM17 NAE1 GRIN1 APAF1 UQCRC1 LPL APP CASP9 CASP8 APOE PAF1 SNCA RTN3 PSEN2 RTN4 CDK5 TNF PLCB1 CALML6 HEL-S-162eP CALM1 CASP3 PLCB2 PPP3R1 TNFRSF1A ERN1 GRIN2B CDK5R1 FADD CYCS PMC6483058__F5 Illustration for cut-edges and the CTGs in AD pathway from KEGG SNCA PSEN2 GSK3B CDK5 HEL-S-162eP APAF1 PSEN1 ERN1 APP CASP9 CDK5R1 FADD CYCS APOE PMC7059166__F4 Cross talk dialogue between inflammatory and WBC‐signalling pathways in MPTP‐induced SVZ plasticity is lost with age WNT1 GSK3B HMOX1 PMC5309231__F3 Downstream effects analysis enables prediction of the effect of gene expression changes in each treatment PRTN3 c-fgr PRKCB TNFSF10 CREM CASP9 BCL2L1 TNFRSF10B TNF TGFA PMC7186644__F1 Canonical Wnt/Beta-catenin signaling depends on the control of Beta-catenin degradation and translocation to the nucleus to activate target genes transcription APC MYC LRP5 CCND1 LRP6 DKK1 PMC6256358__F1 Tankyrase function in cancer POLE AMOT PTEN PMC7226605__F3 Anti-cancer effects and cell death pathways regulated by cannabinoids and the classical cannabinoid receptors ATF4 EIF2A TRIB3 MTOR PMC8055291__F5 Illustration of TNF signaling pathway influenced by major putative targets of GBKC TRAF1 PTGS2 MMP9 TRAF3 IL6 CCL2 TRAF2 IL1B PMC8497507__F7 Schematic showing the roles of mGluR2/3, mGluR1 and DGK in controlling responses evoked by MF activation PLCB4 DGKB DGKG GRM2 KCNJ6 TRPC3 PMC1479816__F3 Pathways involved in mesenchymal cell proliferation and differentiation induced by G protein coupled receptors (GPCRs) GRB2 ARHA RHO MTOR PMC5987716__F2 SOD-dependent ROS signaling in mammalian cells SRC HEL-S-44 PTEN HSF1 PRX TF PMC6131212__F7 Activation mechanisms of the Hippo kinase signaling cascade LATS1 SLMAP LATS2 PMC4834478__F8 microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling STAT1 STAT3 BAX PMC4101832__F2 Processes and outcomes involving leptin, OB-R, Notch1, Notch4, IL-1R tI, JAG1, DLL4, VEGF, VEGFR2 (KDR), EGFR, AR and Ki67 (MKi67 gene) in the development of breast neoplasms LEP VEGFC DLL4 VEGFA VEGFB MKI67 PMC4701060__F1 Signal transduction pathway like mitogen-activated protein kinase/extracellular signal-regulated kinases signaling pathway BAD FOS APC TNF FYN CDK2 MDM2 GRB2 SRC SMO CDK4 JUN FADD STAT3 BAX PMC2744676__F2 Diagram depicting proliferative and survival signaling pathways in cells EGF PI3 BAD EGFR CDK4 MTOR CDK6 BAX PMC7313395__F3 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the Cell Cycle Pathway in Trypanosoma cruzi-infected myoblasts ATM RAD21 STAG2 SKP2 PMC3241824__F1 Operation of the mammalian Hippo pathway in mouse intestinal epithelium and human colon cancer YAP1 PMC7313395__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the JAK/STAT Pathway in Trypanosoma cruzi-infected myoblasts FHL1 CSF3 GFAP PIR CSF3R MTOR STAT1 PIM1 PIAS2 EP300 CLCF1 HEL-S-11 PIAS1 GRB2 TYK2 JAK3 IL-21 JAK1 STAT3 PMC8632942__F6 Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease STAT2 IRF7 TES IFNGR2 IFNAR2 IFNAR1 IFNLR1 STAT1 ISG15 OAS1 TYK2 JAK1 IFNGR1 IFIH1 IRF-1 IFIT1 PMC5362109__F2 Autoimmunity in vitiligo is driven by the IFN-Gamma-CXCL10 cytokine signaling pathway CXCR3 CXCL10 CXCL9 JAK1 PMC7272051__F3 Unveiling functional motions based on point mutations in biased signaling systems: A normal mode study on nerve growth factor bound to TrkA BAD FRS2 GRB2 CR2 IRS1 PMC11788965__F1 Simplified brassinosteroids (BR) biosynthesis and signalling pathways BAK1 UGDH BIN2 ABCB1 PRX CPD PMC11514642__F9 Abnormal expression of MECOM in uterine corpus endometrial carcinoma and its mechanistic involvement in regulating the Hippo signaling pathway and affecting cell cycle and apoptosis SMAD2 EVI1 CCND1 FOXP3 PMC4165418__F3 AKT's role in the NER pathway ERCC1 XPA PCNA PMC4165418__F4 AKT suppresses the HR pathway and activates the NHEJ pathway via many mechanisms RNF8 ATM MDC1 RAD51 BRCA1 PMC11276987__F3 Maladaptive UPR and endoplasmic reticulum (ER) stress-mediated inflammation VIT ATF4 EIF2A TNF TRAF2 XBP1 PMC3499080__F2 Alterations in the NRF2 canonical pathway in livers of mice treated with TMHF GCLM EPHX1 KEAP1 GCLC FTH1 FTL FKBP5 HEL-S-107 UBB TXN AOX1 HEL-S-94n USP14 GPX2 CCT7 HEL-75 PPIB VCP CLPP PMC11276987__F4 Unfolded protein response signaling with their regulating microRNAs ATF4 EIF2A TRAF2 XBP1 PMC8021562__F6 TOPORS-AS1 regulated by VDR, interacting with hnRNPA2B1, and inhibiting the Wnt/Beta-catenin signaling NR1i1 APC HNRNPA2B1 PMC3137930__F8 Analysis of p53 target genes in melanocytes treated with Nutlin-3 for 18 h TIGAR SCO2 FOXM1 KLF10 GML PTEN DTL PIM1 PERP MDM2 NOTCH1 CDCA3 MCM10 NOC2L SSRP1 TAF6 BAX CUL4A ID3 TK1 KLF7 CBX1 NFKB2 CDK2 PCNA PMC11276987__F2 Schema of pathways producing and utilizing endoplasmic reticulum (ER)-derived H2O2 HEL-S-97n NOX4 GPX8 PMC9163972__F10 Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐KB Signaling Pathway CCR2 CCL7 CCL2 PMC9655277__F1 Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease PTH RAC1 MTOR ROS1 PMC11276987__F7 Adiponectin signal transduction [118] ADIPOR1 ADIPOR2 PTEN APPL1 PMC5340150__F1 Autophagy in infection, inflammation, and immunity NLRP3 HMGB1 ATG16L1 ATG12 TRAF6 RIGI MTOR AIM2 IL1B NOD2 PMC11276987__F5 Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review NLRP3 IL6 MTOR HSF1 SIRT1 PMC7237121__F1 CDK4/6 inhibitors and possible combined therapy with CDK4/6 inhibitors CDK4 MTOR CDK6 PMC11763662__F1 Various cell signaling cascades involved in breast cancer EGF NUMB SMAD2 APC EGFR GLI3 SMAD4 SMO MTOR AURKA STAT3 PMC4281841__F2 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases CES1 DGAT2 NR1C1 PMC4281841__F3 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases IRS1 PMC3478884__F1 Emerging role of nuclear architecture in DNA repair and genome maintenance RNF8 ATM ATRIP RAD50 ATR MRE11A PMC3711797__F4 Mathematical model of type I IFN signaling pathway STAT1 IRF-1 SOCS1 PMC1304358__F3 Examples of extreme signaling pathways of the JAK-STAT signaling network STAT2 IFNE PMC7128030__F1 Bile acid synthesis CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC7867637__F2 High glucose on fibroblast activity and function SPARC IL1B CTGF PMC11763662__F6 Representative molecular targets in breast cancer, along with the corresponding immunotherapeutic and targeted treatment approach EGF APC EGFR GRB2 SRC CDK4 CDK6 PMC7785232__F6 GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection CD44 CD40 CD80 MERTK CD1C IFNG PMC11763662__F5 Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review SAMD3 CXCL1 SOX2 CX3CL1 TGFBR2 CCL2 CD163 IL15RA PFKP TGFB1 HK2 HLF STAT3 PMC11763662__F3 Culmination of signaling pathways in the tumor stroma microenvironment involving cancer-associated fibroblasts (CAFs), adipocytes, and mast cells EGF CXCL1 CCL8 PDGFRA FGF2 CXCL3 CCL5 CCL2 HEL-S-104 CXCL16 FAP FABP5 CD36 PMC9095358__F9 Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NFKB Signaling Pathway Affects Chondrocyte Pyroptosis NLRP3 MYD88 GSDMD PMC8802127__F7 Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway EIF5A2 GC PMC9065418__F1 Association of TGFB Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections HP SMAD2 TGFBR1 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7061757__F8 Crosstalk between EGRF inhibition and TLR4 pathways in HNSCC TLR4 SRC MYD88 PMC7542117__F5 Core HIF-1 signaling pathway in THSWD against DR IGF1R EPO VEGFA INS VHL TFRC HEL-S-162eP FLT1 TLR4 IGF1 NOS2 KEL HEL-S-133P TF PMC3287012__F1 Signaling through CD44: hyaluronan binding to a receptor such as CD44 or RHAMM will cause a conformational change in the receptor HGF TGFBR1 CD44 CDC37 ADAM10 RHO PTEN LPA ADAM17 PMC2838843__F3 PTEN signaling pathway BAD PTEN PMC3844070__F1 The IFNG signaling pathway STAT1 IFNGR2 IFNGR1 PMC5964095__F10 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1A signaling pathway MTOR HEL-S-133P HK2 PMC6299648__F5 Oxidative status and leptin signalling pathway in human mammary epithelial cells COX2 STAT3 PMC11015925__F4 Circulating Levels of HOTAIR- lncRNA Are Associated with Disease Progression and Clinical Parameters in Type 2 Diabetes Patients PIK3R1 PRKCE MAPK9 NRAS PTEN IL6 NR1C1 FOXO1 PDPK1 IKBKB PPARGC1A MAPK1 STAT3 PMC6131212__F1 Activation mechanisms of the Hippo kinase signaling cascade NF2 LATS1 LATS2 PMC9925018__F8 KDM4D and Hippo signaling pathway in the regulation of cell cycle activities KDM4D FOXM1 YAP1 GC MYC AURKB PMC2913455__F7 E-selectin–mediated slow rolling BTK c-fgr LYN CD44 SYK PMC7546902__F4 Engineered biosynthetic pathway for geraniol in S ATF1 IDI1 MAF1 IPP PMC8481335__F2 Mitochondria in ferroptosis MFN1 CGAS GPX4 MITA CISD2 DGUOK SLC25A37 CISD1 SLC25A28 LONP1 AIFM1 FES FXN GLS2 ISCU POLG PDK4 HMOX1 MFN2 FH MPC1 IREB2 DHODH TFAM PMC6538180__F3 Transcriptional changes after herpes simplex virus type 1 infection in human trabecular meshwork cells DUSP5 ATF3 GADD45A CCNL1 TGFB1 RHOB PMC8481335__F1 Core mechanisms of ferroptosis HEL-S-89n GPX4 MPO LPCAT3 FACL4 SLC7A11 PLA2G6 CISD1 NFE2L2 LCN2 HEL110 POR AIFM2 ACSL1 SLC3A2 DHODH ACSL3 TF CD36 PMC5562070__F1 TGFB signaling induced apoptosis is modulated by the UPR cascade ATF4 SMAD2 EIF2A SMAD4 XBP1 PMC3430120__F2 Summary of pathways controlling muscle protein synthesis (MPS) and muscle protein breakdown (MPB) IGF1 MYF5 MTOR PMC4548225__F2 LGR4-Wnt/Beta-catenin signaling pathway ZNRF3 APC GSK3B LRP5 IQGAP1 LRP6 PMC8481335__F4 Endoplasmic reticulum in ferroptosis MFN1 CGAS GPX4 MITA LPCAT3 FACL4 KEAP1 SLC7A11 CHAC1 MTOR MFN2 SCD ATF4 EIF2A STK11 SLC3A2 ACSL3 PMC7647682__F3 Putative molecular mechanisms and signaling pathways that may regulate the endothelial-to-mesenchymal transition (EndoMT) process in systemic sclerosis SMAD2 SMAD4 PMC9583547__F1 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex SHBG GABRA2 GABRB2 PMC3313080__F2 Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate ATG12 ATF4 GC EIF2A UNK PMC12165590__F3 Applications of extracellular vesicles in osteoporosis VEGFA CLEC11A HEL-S-133P CTHRC1 PMC9583547__F3 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex MAP2K1 EGFR GRB2 NR3C1 SRC RAF1 HRAS PMC8578048__F2 Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress E2F4 SMURF2 TRAF1 PDK2 SMAD4 PTEN COL1A1 PMC5394545__F5 High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage CTSK TLR9 CD6 SHE IRAK4 IRF3 IL6 MYO18B CPO PLAC1 LBP LAMC1 RASIP1 FADD TIRAP PMC9547585__F7 The let-7f-5p regulates the PI3K/AKT/COX2 signaling pathway in forest musk deer lung fibroblast cell COX2 MUSK PIK3CA PMC6597188__F1 TNF-driven cell death in donor organ as a barrier to immunological tolerance TRADD CYLD RIPK3 TNF TRAF2 FADD MLKL PMC5011664__F1 Canonical wingless/int-1signaling pathway BTRC APC GSK3B LRP5 LRP6 CSNK1A1 PMC4039567__F8 De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways CXCL1 TLR4 CS CXCL2 CCL2 MYD88 PMC5011664__F2 Non-canonical wingless/int-1 signaling pathway TSC2 FYN ATF2 SRC ARHA RYK ROR2 MTOR PMC4644789__F1 Interplay of TrkB and GR signaling pathways in the CNS GCGR CRH GC SHE CRTC2 BDNF PMC5836295__F1 Regulation of IL-33/ST2 pathway by sST2, IL-33 neutralizing antibodies, and GSK3Beta-regulated ubiquitin-proteasome system FBXL19 GSK3B IL33 PMC7232267__F5 Micro ribonucleic acid (miRNA) cross‐talk between miR 29 and miR let‐7 in the anti‐endothelial mesenchymal transition action of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (AcSDKP) FGFR1 DPP4 TGFBR1 PMC8047194__F1 Hippo signaling pathways in Drosophila and mammals HEL70 NF2 VGLL4 LATS1 FAT2 FAT3 CDK7 FAT4 PMC7232267__F4 Fibroblast growth factor receptor 1 (FGFR1)–B klotho complex plays roles in endothelial homeostasis FGF21 FGFR1 FGF19 PMC4975621__F5 CAR targeted miRNA and mRNA in liver cancer ABCC3 ADIPOR2 CYP2A6 NR1C1 MBTPS1 HEL-S-78p INSIG1 IGF1 LIPA NR2F6 OGT ABCC1 APOA5 SERPING1 ABCC2 STAT3 FASN PMC8188209__F11 Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles VTN FH C1S CR1 PMC9100923__F1 Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure HEL-S-61p MTR MTRR PEMT PMC3245622__F1 PI3K/Akt signaling pathway is involved in several human cancers BAD PTEN MTOR PMC9601721__F3 Whole-Exome Sequencing Reveals Pathogenic SIRT1 Variant in Brain Arteriovenous Malformation: A Case Report FAR1 ATG12 INS PTEN INSR NLK ATM CDK2 MDM2 KLF2 BNIP3 SKP2 STAT3 PMC6902869__F1 Tumor-targeting bacteria engineered to fight cancer CD14 TLR5 TLR4 IL1B IFNG PMC9553029__F3 NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain HP PANX1 TG TRPV1 PMC7461546__F5 NME protein-histidine kinase functions LHPP KSR1 HEL-S-132P EGFR TRPV5 SUCLG1 NME2 ACLY PMC11194209__F1 Major abnormal signaling pathways in TNBC EGF NOTCH4 APC EGFR LRP5 GRB2 SHE NOTCH1 FZD7 LRP6 PTEN MTOR PMC4748524__F1 TLR signaling pathway genes TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TIRAP PMC7272661__F2 Graphic illustration of molecular autophagic pathway ULK1 ATG12 ATG3 AMBRA1 FYCO1 ATG101 UVRAG ATG10 MTOR ATG14 DKFZp686F0183 PMC3872270__F2 Many ways to inactivate the p53 pathway in cancer ATM MDM2 PTEN PMC9284706__F2 Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death CD80 CTLA4 PANX1 HIF1A PMC7033608__F3 Possible mechanism of Wilms tumor 1 antisense RNA (WT1-AS) functioning FOXN2 WT1 PMC7602874__F2 Schematic diagram of the role of the cGAS-STING pathway in cancer immunity TH SLC19A1 PMC7602874__F1 Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signalling pathway TBK1 CGAS ENPP1 IRF3 PMC3998523__F1 Sphingolipid pathway and subcellular localization of sphingolipid enzymes DES SKI SMS PMC7876374__F2 Effect of EGCG on miRNA and Ca2+signaling in T cells PTEN MTOR ORAI1 STIM2 ELL PMC4438218__F1 Proposed model for the regulatory role of methenyl-dH4MPT in methylotrophic metabolism in M HP GCK HPR PMC9118050__F2 Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities CXCL1 LBR SMAD2 WNT7A CD44 CXCL2 HIF1A TP53INP1 COX2 CYLD CXCR4 FAP TXNIP CXCL12 PMC3241001__F1 Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry TSC2 TSC1 APC GSK3B LRP5 LRP6 PTEN EIF4E MTOR RHEB PMC9843445__F3 Major roles of the circadian clock in cancer ALDH3A1 MTOR PMC5213309__F5 Soluble tumor-derived signals change the phenotype of the tumor-associated macrophage, by induction of the mTOR pathway and glycolysis, and epigenetic changes MTOR PMC4047762__F6 ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway RBPJ HEY2 DLL4 SMAD4 ID1 SMAD1 DKFZp781O1323 PMC4248790__F4 Piwi proteins and piRNAs step onto the systems biology stage FKBP6 TDRD1 DNMT3B DNMT3L HIG-1 MOV10L1 PMC6726984__F2 SnoRD126 activates the PI3K-AKT signaling pathway through FGFR2 and snoRD50A/B and affects the MAPK signaling cascades PDK2 MYC FGFR2 PMC6329944__F1 Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway PTH1R CSF1 PMC5751231__F7 Regulation of miRNA expression in response to maternal disease and stress E2F2 FOS PRKG1 ADRA1A MYH7 CCND2 PMC7992277__F10 Na+ controls hypoxic signalling by the mitochondrial respiratory chain HEL-S-11 MCU NACA CAD PMC9580515__F5 Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages CD47 MTOR STAT3 PMC7356105__F2 Illustration depicts the localization of the gene products by cellular compartmentalization and indicates the downregulated expression of NF-kappaB signaling pathway as an effect of vitamin E formulation treatment on heat killed C EGF LTA NGF TGFA TRAF2 TIRAP PMC7728999__F4 LncRNA XLOC_221242 regulates the expression of DNER, which is the key factor of Notch signal pathway DNER RBPJ SKP1 CDH2 PMC3604104__F5 Gene Expression Networks Underlying Ovarian Development in Wild Largemouth Bass (Micropterus salmoides) GSK3B PDPK1 PMC3243113__F10 MULTIPLE WAYS TO DIE: DELINEATION OF THE UNFOLDED PROTEIN RESPONSE AND APOPTOSIS INDUCED BY SURFACTANT PROTEIN C BRICHOS MUTANTS ATF4 TRAF2 PMC9013399__F1 Significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease NAPRT NAMPT HEL-S-90n NNMT PMC4935227__F2 WWOX regulates multiple signaling pathways ERBB4 RUNX2 SHH SRC DVL2 SMO TNF WWOX PMC8360401__F2 Ischemic postconditioning for stroke treatment: current experimental advances and future directions BAD TLR4 BCL2 IRAK4 MTOR IL1B PMC4935227__F3 The potential role of WWOX in anticancer drug-induced cancer cell apoptosis MTOR DKFZp686F0183 WWOX PMC8036776__F1 NF-kB pathway targeted by GSH COX2 IL6 IL1B PMC3155407__F1 Murine model of the multiple actions to suppress immune surveillance of exosomes released from neoplastic cells CD14 JAK3 FOXP3 PMC4159787__F3 The relationship between RAGE and neurite outgrowth after spinal cord injury HMGB1 S100B CDC42 PMC4724957__F3 Metabolic pathway map of Parachlorella kessleri ACD ATG14 PMC8708558__F2 Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression MFGE8 COL18A1 BMP1 TOR4A SPON2 FHL3 EMILIN1 PLOD1 HAPLN3 HHIPL1 PDLIM7 ADAMTS7 PDLIM2 ZYX NOTCH1 HEL113 PMC2533793__F10 Model for negative regulation of Wnt signaling pathway by corepressors SMRT and NCoR HDAC3 TCF4 PMC5926502__F4 BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells CD14 TLR4 ATF2 MYD88 AK1 TK1 PMC4013446__F2 Functional significance of differentially expressed miRNAs—miRNA-512-5p, 190a and 200b-3p (Ingenuity pathway analysis) ROCK2 RAPGEF1 HEL70 BRAF MAPK7 LEMD3 PHF6 PAG1 ACVR2A RECK SLC23A2 RAPGEF2 RPS6KA2 TAF4 PMC7457075__F7 Possible mechanism of anti-inflammatory effect of OEA on colitis TRAF2 IL1B NR1C1 PMC4629442__F1 EGFR and its signal pathway EGF BAD EGFR GRB2 SRC BCL2 PTEN MTOR TGFA STAT3 PMC3548163__F2 Modes of action of environmental risk factors for autism at excitatory synapses in the CNS IGF1R IGF1 GPR39 PMC5964985__F2 Atrial fibrillation genes in calcium signaling and ECM–receptor interaction ITGA1 PTGFR ITGB3 EGFR ITGB6 PLCG2 ITGA4 PTGER3 SDC2 TTN RYR2 LAMA3 PLCB1 PRKCA PLCB4 ERBB4 PRKCB HSPG2 CHRM3 SYK RYR3 HTR2A CD36 AGRN PMC10933535__F1 Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration TH EGF TRADD APC CCR4 PTEN TNF FOXP3 IFNG TSC2 ERBB2 ZAP70 CCL17 CD80 CCL22 TRAF2 SOCS1 PMC6321258__F1 Interaction between metabolism and histone acetylation and DNA/histone methylation PDC ACSS2 ACLY PMC2760069__F1 Brothers and Sisters: Molecular insights into arterial-venous heterogeneity FOXC1 HEY2 NRP1 FLT4 NOTCH1 SOX18 FOXC2 SOX7 EPHB4 NRP2 PMC7324687__F2 Dopamine interaction with adenosine and NMDA signaling JUN PER2 PER1 PMC4650770__F1 Biosynthetic pathways of histo–blood group antigens H1-2 FUT1 FUT4 FUT6 GAL FUT5 FUT9 hCG_1998026 FUT3 PMC7322524__F1 Cell death pathways triggered by DNA sensors TBK1 CGAS IRF3 AIM2 IL1B GSDMD PMC7322524__F2 Cell death pathways triggered by RNA sensors TBK1 KL RIPK1 RIPK3 IRF3 FADD TLR3 ZBP1 MAVS MLKL BAX PMC8972192__F2 Exploration of Novel Pathways Underlying Irreversible Electroporation Induced Anti-Tumor Immunity in Pancreatic Cancer STAT1 TLR9 IRAK1 TRAF6 MYD88 JAK1 TRAF4 IFNG PMC5897459__F2 Biosynthetic pathway of thylakoid glycerolipids from phosphatidic acid (PA) in Arabidopsis thaliana CDS1 PGP CDS2 PMC8744307__F2 Inflammasomes in vascular cognitive impairment IL10 NLRP3 NLRC4 NLRP1 AIM2 GSDMD PMC5758348__F2 Illustration of the cellular and molecular targets of total and individual Panax notoginseng saponins (PNS) on neural cells destroyed by Alzheimer's disease ChAT RB1 REL PMC6830763__F1 Brief description of the interaction of a CD4+ T cell with B cells CD40 CD80 UNG IFNG PMC8292787__F1 Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy IL5RA PC BCR IL33 TSLP PMC8700074__F1 Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases AHRR AHR CYP1A1 REL KLF6 PMC3782218__F1 Role of the proteins and mediators involved in iron homeostasis and impact of hereditary hemochromatosis protein mutations in chronic kidney disease BMP6 EPO HAMP HFE IL6R TFR2 STAT3 PMC7356105__F3 TNF pathway inhibition in HGF in response to C MAPKAPK2 A2M UNK TNF TRAF2 PMC10487821__F9 Activation of the Wnt/Beta-catenin signaling pathway via lithium released from the IPN-Li hydrogel APC GSK3B LRP5 LRP6 PMC6818723__F14 Hypothetical signaling network integrating top genes identified through Rasch analysis CASR HDAC3 FXN MTOR ITGB1 BGLAP RPTOR PRNP PLXNC1 FYN AEN MDM2 ARC APOE PMC2674702__F1 Metabolism of extracellular and intracellular bioactive lipids LPA PMC5364998__F2 Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? HMGB1 TLR9 RAC1 PMC8285047__F2 Nitric oxide in orthodontic tooth movement (Review) COX2 SRC PMC7906391__F5 Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease APP PMC1571327__F6 FGF, Wnt and Tbx3 in epithelial–mesenchymal interactions regulating mammary gland initiation LEF1 FGFR1 TBX3 FGF10 PMC6295738__F4 The enzymes of bile acid synthesis AMACR BAAT PMC3612991__F2 Harmonies Played by TGFB in Stem Cell Biology NOG SOX2 NODAL LIF GSK3B SMAD4 PMC2776288__F2 Crosstalk between ionizing radiation-induced apoptosis and NFKB pathway ATM TRAF2 BAX PMC2776288__F3 Crosstalk between apoptosis and NFKB signaling by IAP-antagonist MAP3K7IP1 TRAF2 PMC3362995__F5 The WNT10b and galanin-mediated signaling pathways linked to adipogenesis LPL DKK2 SFRP5 PMC2662368__F2 T cell differentiation proceeds along distinct pathways following antigen presentation by DCs IL10 AHR STAT4 GATA3 IFNG STAT3 FOXP3 PMC12133554__F2 Molecular mechanisms of LGR4 in tumor bone metastasis RNASEK LRP5 DKK1 PMC2704819__F2 Catabolic pathways encoded by the T POR PMC12133554__F1 Molecular mechanisms of LGR4 in bone metabolism RSPO1 BMP2 NFATC1 ATF4 LRP5 PMC8755460__F3 K63 ubiquitination in immune signaling TBK1 CGAS IRF7 NLRP12 NLRX1 TRAF3 TRAF6 IRF3 FOXP3 NLRP3 RIPK1 BCR SHARPIN TRAF2 NLRC3 MAVS PMC9452849__F13 Hope for bone regeneration: The versatility of iron oxide nanoparticles FGFR1 OMD PDGFRA RUNX2 GRB2 DKK1 PMC4082789__F1 Exploiting sulphur-carrier proteins from primary metabolism for 2-thiosugar biosynthesis HEL-S-62p C6 PMC7554980__F2 mRNA in vitro transcription and innate immunity activation RNASEL TLR8 TLR7 IRF7 EIF2A RIGI MYD88 TLR3 MAVS PMC3670240__F1 Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells LIF TBX3 GSK3B MYC GRB2 TRIM8 TRIM6 STAT3 PMC8927697__F4 Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies HMGB1 COX2 COX1 PMC2993794__F1 Stimuli and factors involved in yeast chronological aging TH HTRA2 PMC7072724__F8 PP2A regulation by S67/S62-phosphorylated ENSA/ARPP19 in human platelets and the impact of PKA/PKG on it VASP ENSA ARPP19 PMC8832032__F4 Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke TBK1 PINK1 ATG12 BNIP3 ATG10 PGAM5 DKFZp686F0183 PMC3185810__F2 Alteration of the IFN-I signaling pathway by HTLV-1 STAT2 TYK2 IFNAR2 JAK1 IFNAR1 PMC6330656__F1 Targeting ERBB Activation Mediated by CD74-NRG1 ERBB2 ERBB3 NRG1 CD74 PMC7823493__F2 Synovial membrane and bone interactions in rheumatoid arthritis LPA TNF IFNG PMC9158144__F7 Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer MT2A LATS2 PMC3185810__F1 Interplay between HTLV-1 and the type-I interferon (IFN-I) induction pathway TLR8 TLR7 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC6361815__F1 Different types of GSLs A4GALT UGCG B3GNT5 B4GALNT1 A3GALT2 PMC10216109__F2 Melatonin antioxidant properties and tryptophan metabolic pathway ASMT CAND2 PRX PMC4043215__F1 Hypoxia-Activated Pathways Leading to Cancer Stem Cell Maintenance POU5F1 CD24 PMC6181033__F7 Proposed model for the role of ZmbZIP4 in maize root development and stress response ARF3 PMC2695822__F9 Display of genes with high expression in IVF embryos NGDN PRNP ELL PMC10243716__F2 Ferroptosis as a vulnerability in cancer HEL-S-26 GPX4 FACL4 NF2 ELOVL5 EGFR VHL NOX4 TFRC DHODH HILPDA PMC4890337__F10 MWCNTg promote the EMT through the TGF-Beta-mediated Akt/GSK-3B/SNAIL-1 pathway TGFA PMC8425214__F1 Regulatory networks of the Hippo signaling pathway in cancer development LATS1 LATS2 PMC5015648__F2 AB-crystallin negatively regulates multiple steps in the intrinsic (mitochondrial) apoptotic pathway CASP3 CASP9 BAX PMC2773630__F6 Molecular interactions during pheromone induced cell polarization FAR1 CDC2 CDC42 PMC8425214__F4 Regulatory networks of the Hippo signaling pathway in cancer development CA3 LATS1 RHO LATS2 PMC6206039__F7 Scheme summarizing the inhibition of cisplatin-induced nephrotoxicity by maltol via the down-regulation of AMPK through PI3K/Akt pathway CASP3 TRADD CASP9 TNF MTOR TRAF2 FADD BAX PMC8425214__F2 Regulatory networks of the Hippo signaling pathway in cancer development SIAH1 AMOT ATF4 USP9X LATS1 RHO SIAH2 PMC5597640__F9 Model for replication stress and its aftermath in the absence of BRCA2 BRCA2 RAD51 MRE11A PMC8425214__F3 Regulatory networks of the Hippo signaling pathway in cancer development TBK1 RUNX2 SRC LATS1 MAVS PMC9393183__F2 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression HEL-S-62p MASP1 C1S PMC9393183__F3 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression PLG MASP1 ACE2 PMC11265800__F6 Signaling pathways in melanoma cells and tissue MMP2 CSPG4 PMC2887297__F1 Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease ELF2 ATF4 EIF2A PMC8584052__F2 P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis PYCR2 MYC PRODH PMC9452720__F1 How zoledronic acid improves osteoporosis by acting on osteoclasts CTSK TRAF6 CSA2 PMC6349126__F1 Schematic outline of PC metabolism in yeast GDE1 GPC1 PLB1 PC PMC5701083__F2 Signaling pathways involving PFKFB3 EGF F2 APC PMC4209037__F3 Gene association network (GAN) 3 in lung DAZAP2 PPL SKIL SMURF2 ECSIT EEF1G FUCA1 PMC5701083__F3 Roles of PFKFB3 in different cancer cells SP1 PMC2814429__F2 Regulation of autophagy and apoptosis HEL-S-62p ATG12 ATG3 ATG10 MTOR DKFZp686F0183 FADD PMC9356572__F2 Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion STAT2 IRF7 IMPACT TRAF3 IRF3 WAS TLR3 MAVS PMC10881233__F2 Action of cryoablation combined with immune checkpoint blockers APC CD80 PMC6706170__F1 AvB5 integrin/FAK-mediated phagocytic pathway in TM-1 cells TIAM1 SIRPA CD47 ARHG HEL-S-28 GULP1 DOCK1 RAC1 CD36 PMC8514698__F2 Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine ATG12 ATG3 LAMP2 ATG10 ATG14 DKFZp686F0183 PMC7641543__F1 EMT transcription factors by Wnt/GSK3B/Beta-catenin/Snail and PI3K/AKT/GSK3B/Snail signaling EGF APC EGFR GSK3B IRS1 PMC10743660__F3 Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies HMGB1 IGF1R HGF SMAD2 APC SMAD4 PTEN MYD88 TLR4 IGF1 ANXA2 CXCR4 SRC CXCL12 PMC11720236__F2 Mechanisms of exercise modulation of pulmonary fibrosis TLR4 CXCL5 SMAD2 IL8RB LRP6 PMC8168423__F9 Oral intake of Lactobacillus plantarum L‐14 extract alleviates TLR2‐ and AMPK‐mediated obesity‐associated disorders in high‐fat‐diet‐induced obese C57BL/6J mice MYD88 HEL-S-104 TIRAP PMC10743660__F4 Immune component of inflammation-induced EMT in lung cancer CCR2 SMAD2 SMAD4 CCL2 IL6R STAT3 PMC11720236__F3 Exercise modulation of renal fibrosis NOX4 NR1C1 SIRT1 PMC10743660__F6 Inhibition of inflammation-induced EMT by PTs HMGB1 EGF SMAD2 EGFR APC SYNPO LRP5 SMAD4 LRP6 TRAF6 SKP1 RHO MYD88 MTOR RBX1 SMURF1 TLR4 TIMP1 CDH2 SKP2 STAT3 PMC11720236__F1 Pathogenesis of fibrosis: After tissue injury, immune cells (mainly macrophages) are activated and release cytokines (e SMAD2 SMAD4 PMC10743660__F1 Key molecular events of EMT CDH2 PMC11240630__F1 Pathways associated with the signaling of BCSCs APC GSK3B SMO MTOR PMC11720236__F4 Exercise modulation of myocardial fibrosis FGF21 LOXL2 FGF23 FOS SMAD2 FSTL1 NRG1 CHI3L1 SIRT1 STAT3 SIRT3 PMC11720236__F5 Antifibrotic mechanisms of exercise: Exercise exerts its anti-fibrotic effects by directly or indirectly (secreting exerkines or targeting microRNAs) affecting multiple signaling pathways associated with fibrogenesis FGF21 FSTL1 LRP6 CHI3L1 NR1C1 SIRT1 PMC9366252__F3 Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor SMAD2 VTN APC TGFBR1 SMAD4 TGFBR3 CDH2 MTOR JUN PMC10743660__F7 Inhibition of stemness by PTs RARA EGF SOX2 APC EGFR HEL-S-53e SKP1 RBX1 SKP2 STAT3 PMC3318742__F8 Model of how RACK1 mediates activation of SHH/GLI signaling in NSCLC Cells SHH SMO PMC5605425__F1 Linking long non-coding RNA to control bile acid signaling and cholestatic liver fibrosis S1PR2 EPCAM BCL2 CYP7A1 PMC6500875__F2 Annexin A1 in inflammation FPR2 TNF PMC6500875__F3 Mechanisms of Annexin A1 in tumorigenesis SMAD2 SMAD4 PMC5884027__F2 NRF2- and SIRT1-signaling pathways targeted by antioxidant compounds IGF1 FOXO3A GSK3B PTEN SIRT1 PMC6443714__F1 The cytoplasmic destruction complex constitutively targets Beta-catenin for degradation MSC LRP5 PMC5872689__F6 Suggested mechanism of pinitol-induced effects on the insulin secretion pathway IL10 CAD C4A PMC5884027__F1 Schematics of the metabolic pathways and their cellular localization affected in branched-chain organic acidurias and homocystinuria disorders mentioned in this work BCKDK DLD TCN2 PCCA DBT PCCB MMADHC CD320 CBL ABCD4 PC MTRR CBLC PMC1820632__F1 Cytokine-Effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression STAT1 TYK2 JAK1 STAT3 PMC5827745__F2 BCR‐ABL pathway IHH BCR FOXO3A SMAD2 GRB2 SMAD4 SMO PTEN MTOR PMC8112168__F1 Multiple catalytic functions of IPMK in inositol biosynthesis pathway IP6K1 IPMK PTEN PPIP5K1 PMC7565564__F2 Examples of molecular mechanisms underlying the effects of uremic toxins on various cells, with focus on the aryl hydrocarbon receptor signaling (AHR) pathway AHR SRC TF PMC5187886__F2 Possible mechanisms of estrogen or EED action NRF1 FOS PTEN SP1 JUN PMC7773746__F1 Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway BCL2 BAX PMC6678879__F8 miR526b and miR655 overexpressing cells showing significant down regulation of tumour suppressor gene phosphatase and tensin homolog (PTEN) mRNA expression COX2 PTEN PMC5312548__F9 The role of NAD+ in the macrophage metabolic switch NAMPT HIF1A SIRT1 PMC6619438__F2 Innate immune recognition of Chlamydia CD14 CGAS TLR4 NOD1 IRF3 IRAK4 MYD88 TLR1 EPHA2 NOD2 TLR3 PMC3127207__F4 GenMAPP Diagram of Cell Cycle Pathway Genes Regulated by Luteolin in E2-Treated MCF-7 Cells CCNA2 PLK1 GSK3B CCNH CDC25B RB1 CCND3 TFDP1 CDK6 CCND2 CCNE1 CCNB3 CDC6 WEE1 CDK2 CCNB2 CCNB1 CDK4 PCNA RBL1 SKP2 CCNE2 PMC7076373__F1 CDC1 DC development BATF3 XCR1 PDC CLEC4C GIG8 IRF8 CLEC9A PMC3127207__F2 Luteolin Effects on Estrogen Signaling Pathway (ESP) Genes CARM1 HDAC3 NCOR1 GRIP1 PGR CRAT SMARCA4 PELP1 TBP IGFBP1 NRP1 GRB2 SRC DDX5 PCK2 NCOR2 PMC6615902__F4 WNT signaling and regionalization of the GI tract epithelium IHH SOX2 CDX2 SI DKK1 TCF4 BARX1 PMC12043837__F4 Regulatory role of lactylation in glioma pathology KLF15 ALDH1A3 HEL-S-133P PMC8582492__F1 Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A BCR ATM FOS TCL1A PTPRO LYN ZAP70 SYK JUN PNPT1 PMC6912360__F8 Mechanism capable of expressing or inhibiting an effect of Temozolomide (TMZ) MSH6 MSH2 PMS2 PMC5941588__F9 Comparison of networks affected by FA or O3 exposure in females at different stages of the estrous cycle AVEN MYC DKFZp686H13261 CCNJ KIN TNFAIP2 PMC10388730__F6 Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line CD14 EGF FLNA TRAF6 TNF CRKL NLK MAX HP JUND ECSIT RAF1 COIL BDNF TRAF2 PMC4978108__F2 Apoptosis in pancreatic Beta-islet cells in Type 2 diabetes BAD PMC7738964__F3 Peroxisome proliferator-activated receptor (PPAR) signaling pathway in the MetaCore analysis CPT1A CPT2 ACOX3 ACADM RXRA PMC7937674__F8 Schematic overview for the positive feedback loop between OTUD5 and mTOR signaling pathway MTOR DEPTOR OTUD5 PMC6605495__F1 Nutrient flux through the HBP modulates protein O-GlcNAcylation OGA OGT PMC8441765__F8 Schematic illustration of the proposed mechanisms for paclitaxel-induced growth inhibition in PC9 cells EGF CDK2 EGFR BCL2 MTOR ATR H2AX FADD CCNE1 PMC6605495__F2 Helper T cell differentiation and HBP STAT1 APC GATA3 STAT3 FOXP3 PMC5984665__F1 MicroRNA Regulation of K-Ras in Pancreatic Cancer and Opportunities for Therapeutic Intervention NF1 EGFR GRB2 SPRED1 SPRY1 PTEN PMC9136457__F1 When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response IPMK PTEN INPP5E PLCB1 PMC7216198__F8 Regulatory role of the IPs in immune surveillance in PB CD34+ Cells of PMF JAK2V617F mutated patients STAT1 HLA-A TAP2 CD34 B2M ARG1 IRF-1 IFNG PSME2 PMC2797409__F3 Reconstructed CCM of S GK5 CS POR HEL-S-162eP PMC4347221__F1 Shifting ecologies of malignant and nonmalignant cells following BRAF inhibition BRAF BCR NRAS SYK RAF1 PMC8036963__F3 DNA damage response (DDR) pathway involves sensor, transducer, mediator/amplifier, and effector proteins, which act following the induction of a DNA lesion or replication stress ATM ATRIP ATR H2AX PMC4867368__F7 The mechanistically diverse PF03099 lipoyl metabolism enzymes LIPM LIPA LIPI LPA PMC2579334__F3 Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure PDE3B BAD FYN VAMP2 GRB2 CRAT PTEN EIF4E GRB10 CRK PMC4637204__F4 Systemic Problems: A perspective on stem cell aging and rejuvenation MTOR SMAD1 TGFBI STAT3 PMC4855646__F9 Signaling pathways of TRIAD HNRNPAB PLK1 HTT HNRNPA2B1 PMC8236053__F2 Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis LALBA AQP3 DAP GAL B4GALT1 PMC6927352__F5 Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH CD9 CD47 VASP ARHH CD44 TEC ARHA RAC1 THY1 ITGAM LPL VWF CHAD CD36 PMC8616064__F2 Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms HGF CCL2 LAG3 PMC5131002__F2 YAP mediated gene expression in liver fibrosis ANKRD1 MOB2 AMOT LATS1 RHO PMC8431187__F2 Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling VCAM1 PIM2 TNF STAT3 PMC4336165__F2 Growing recognition of the role for rare missense substitutions in breast cancer susceptibility CHEK2 PALB2 ATM BRCA2 BRIP1 BARD1 RAD50 RAD51 MRE11A BRCA1 PMC7699596__F3 Key autophagy pathway and its regulators (natural compounds) for treating diverse cancers TSC2 ULK1 TSC1 RAF1 MTOR PMC6636509__F8 Proposed model for the impact of targeted therapeutics, vemurafenib (PLX) and trametinib (TRA) on differentiated/pigmented phenotype of melanoma cells DCT MC1R PMC5618570__F2 Glycans and insulin/IGF system in cancer: an integrated mechanism IGF1R IGF1 OGT IGFBP1 MGAT3 HIF1A PMC6027367__F1 Unfolded protein response and NFKB signaling ATF4 EIF2A ATF3 TNF TRAF2 PMC5618570__F1 Insulin/insulin-like growth factor (IGF) system IGF1R IGF1 IGF2 IGF2R PMC4412144__F3 IPA Network TSC22D3 PLEKHF2 WNK1 HOMER1 RING1 CREB1 PITPNB TFRC IMP3 TNFSF13 BNIPL DDIT3 MCAM JMJD6 CREM LITAF SGK1 PMC9388724__F5 Neuronal ferroptosis after intracerebral hemorrhage GPX4 SLC7A11 KLF2 USP11 BAX PMC4245781__F1 Signaling pathways of TRKA activation by NGF NGF GRB2 IRS1 FOXL2 PMC10705282__F4 In PTC, glycolysis is crucial for tumor growth STAT3 PMC6194107__F2 Origins of centromeric breaks RIF1 BLM PTEN TOP2A DNMT3B SMC5 MSH6 RAD51 MSH3 MSH2 ATR MSH4 MSH5 PMC11375557__F2 Transcription Factors and Signaling Pathways in the Process of EMT EGF EIF5A2 FOXM1 GATA6 ITGB6 STC1 EIF4E WT1 FOXC2 BTF3 CEACAM6 SOX9 OVOL2 ARL4C S100P MMP14 MUC4 ERBB2 ZEB2 KLF4 KIF20A SP1 STAT3 PMC3757712__F3 Crosstalk between the Nrf2 and NFKB pathways MAF HDAC3 KEAP1 PMC10705282__F2 Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs LPL LDLR APOE PMC2758290__F1 The SIAE (sialic acid acetylesterase)-Siglec pathway for inhibitory signaling SIAE BCR CD22 LYN PMC3678537__F2 Wound Healing in Development APC GSK3B ARHA RAC1 PMC3622313__F1 Regulation of HDL homeostasis by miRNAs ATP8B1 ABCG1 LDLR ABCA1 ABCB11 TG PMC4052099__F1 Predicted insulin signaling pathway in schistosomes based on the characterization of schistosome insulin receptors, the published S GRB2 MTOR FOXO1 CBL PMC8602684__F2 Metallothionein 1: A New Spotlight on Inflammatory Diseases STAT1 MMP9 STAT3 PMC11585094__F7 Potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis GPX4 KEAP1 SLC7A11 SLC3A2 NQO1 TF PMC11375557__F1 Mechanisms of Epithelial-Mesenchymal Transition EGF CDH2 PMC11697870__F5 Multifaceted biological processes and pathways that are identified to be associated with AD progression BCR ABCB1 GP6 PMC5375109__F1 miR-33 regulation of adaptive fibrotic response in cardiac remodeling DROSHA CCND1 CDK4 ABCA1 PMC1172066__F8 Model depicting how inner ear polarity is generated in response to extracellular signals GBX2 PAX2 SHH PMC4201594__F6A FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis HEL-S-26 HEL-S-87p PGAM1 HEL-S-133P HEL-S-281 HEL-S-68p HEL-S-162eP PMC3746754__F2 Iron metabolism in the eye, a review PCBP1 HFE CP TFR2 PMC8640549__F3 GPR56/ADGRG1 in health and disease ARHA RHO TNF CD81 PMC4613459__F2 Repurposing metformin: an old drug with new tricks in its binding pockets TSC1 IGF1R IGF1 CCND1 RHEB STAT3 PMC4823983__F5 Interaction between the genes differentially expressed in response to HDM CCR3 CCL2 CCR8 FOXP3 IL18 TNFRSF4 EPX CCL24 PRG2 CCL17 RNASE2 IL17A ICOS IL10 CCL11 AREG IL13 CCR4 ADRB2 CCL4 TNLG2B IL25 IL33 IL2RA IL-21 CCL22 PMC8635240__F8 VDR Signaling via the Enzyme NAT2 Inhibits Colorectal Cancer Progression NR1i1 NAT2 JAK1 STAT3 PMC2859139__F1 Immunoregulatory pathways CD40 TGFB1 IFNG PMC3017908__F6 Major pathways affected in NMSC DKFZp686L0365 HHIP SUFU GRB2 SHH PTEN PMC136456__F7 The modulation of cellular signaling pathways by NS5A BAD GRB2 PMC8606660__F6 Intrinsic Mechanical Cues and Their Impact on Stem Cells and Embryogenesis ANKRD1 RUNX2 NF2 ARHA LATS1 MOB1A MOBKL1A LATS2 PMC6072898__F3 Mechanistic aspects of the antioxidant and anti-inflammatory action of berberine RHO SIRT1 UCP2 PMC6537107__F3 Changes in PUFA metabolomes are conserved across pharmacological and physiological models of skeletal muscle injury TH LTA HP LTB PMC6008965__F2 5-Fluorouracil drug pathway demonstrating the interaction of multiple gene products TH GGH REN RRM2 HEL-S-11 FH DPYS DTYMK DUT FPGS PMC8469789__F3 Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes FANCD2 FLT3 PCNA PMC9379326__F2 Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets LPL CYP7A1 ACOX1 PMC8568546__F3 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A YTHDF2 YTHDF1 METTL3 NODAL SMAD2 PMC8568546__F1 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A METTL14 METTL3 NODAL SMAD2 WTAP PMC9600852__F1 Molecular Defense Response of Pine Trees (Pinus spp.) to the Parasitic Nematode Bursaphelenchus xylophilus STS PMC8877616__F1 Current and Emerging Medical Therapies in Pituitary Tumors SMAD2 EGFR SMAD4 DRD2 MTOR PRL TGFBI PMC9149431__F3 All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity TRADD CYLD TRAF2 FADD MLKL PMC5649110__F1 Narni-Mancinelli et al SLC7A5 XCL1 EGR2 ZAP70 SYK CFP IFNG PMC9188247__F8 Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4+ T cells into the infarcted heart via CCL5/CCR5 signaling CCR5 CCR2 CCL5 CCL2 PMC4967210__F13 Schematic summary of novel TXNIP-NFYA-SREBP2/miR-33a-AMPKA/CROT/CPT1/HADHB signaling pathway conferring TXNIP regulation of myocardial fatty acid oxidation HADHB TXNIP CROT NFYA PMC6579706__F1 Unfolded protein response (UPR) EIF2A XBP1 PMC2722767__F3 Application of SysPTM tools ROCK2 NLK APC PROC CER1 SMAD4 ARHA PMC11670700__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905677 ZNRF3 RNF43 LRP5 LRP6 TCF4 PMC4022110__F1 Schematic overview of MBL-dependent activation of the lectin pathway of complement HEL-S-62p C4B_2 C6 C4A PMC9204405__F1 Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research IL10 CCR2 IL6 CCL2 STAT3 CCL3 PMC4441295__F5 Fangchinoline inhibits the growth and invasive potential of gastric cancer cells by inhibiting the PI3K/Akt pathway MMP2 CDK2 MMP9 GSK3B BAX PMC3672943__F1 Integration of Cell Signalling Pathways into Higher Order Networks Sculpts Transcriptional Landscapes RUNX2 TBX5 FOXH1 PMC3635745__F1 Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways CSK PTEN BLK CD79B PTPN22 CD81 BTK FYN CD72 BANK1 CD22 LYN SYK CD19 PMC10888650__F1 Potassium’s (K+) Role in Various Cellular Processes CASP3 IGF1R IGF1 FOS GRB2 CAD JUN CASP8 IRS1 FADD HEL-S-162eP PMC10888650__F4 ABCC8 Expression in Hypoxic and Inflammatory Conditions MYD88 ABCC8 SP1 TRAF2 PMC6819784__F2 Macrophage infection affects host metabolic state and can induce an M1 profile TLR4 F2 HIF1A IFNGR1 UCP2 IFNG PMC3427885__F4 Impact of HCV infection on ILK signaling EPOR COX2 F8 PTEN MTOR RHD PMC12129893__F2 Sources of the microbiota and mechanisms by which bacteria regulate tumor progression TLR4 PMC3925803__F5 Model showing elevated calcium and/or phosphate up-regulate HGF secretion and c-Met activation in conjunction with activation of the PI3K/Akt signalling pathway, leading to SMC mineralisation, which can be inhibited by AdNK4 treatment HGF RUNX2 BMP2 NOTCH3 PMC8745708__F4 Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas NF1 FOSL1 RAC1 MTOR PMC5129910__F8 Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts IGF1R SIRT1 IGF2R PMC7945682__F2 Summary of targets to generate Super-Treg HLA-E MHC2TA CD47 RUNX1 HDAC11 HIF1A MTOR FOXP3 IFNG AHR LRBA DHFR IL2RA B2M USP22 FGL2 IL2RB PMC4538424__F1 MicroRNAs as major players in immune-mediated beta-cell damage in autoimmune diabetes IL16 VAMP2 IRAK1 PMC8660617__F10 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CENPB CENPH CDC20 PLAT ATM KNTC2 APC INCENP ATR CENPA NSL1 PMC8660617__F11 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CDC20 ATM APC EGFR RCC1 HCTP4 CDC2 RAN ATR PMC8660617__F12 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CARM1 E2F4 NR3A2 KEAP1 ATM APC CDK4 RAN ATR CDK6 SKP2 PMC8660617__F13 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients TH PC BCR ATM LAMP2 IL33 GIP RHO ATR XBP1 tal-1 PMC3539736__F3 PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances IL10 CCR6 KLF2 RHEB ICOS FOXP3 PMC8660617__F14 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients FANCD2 ATM SI APC SMO ATR PMC8660617__F15 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients UBE2C MAPK12 ATM APC MAPK14 MAPK1 RAN ATR C13orf34 PMC8630697__F3 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer MFN1 MFN2 GPX4 PMC9536535__F7 Proposed model of S100A8/9 induction PTGIR TLR4 ZBTB40 EBI3 PLA2G1B IL27 S100A8 PTGER4 STAT3 PMC6813793__F3 Cross talk of Na+ and Ca2+signalling between the cell membrane and the mitochondria.Influx of Ca2+ into cells is mediated by multiple cell membrane pathways MICU1 TRPC6 MCU TRPV1 PMC9225892__F8 Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NFKB Pathways VASP CTSK PMC3690520__F3 TCR signaling pathway leading to NFKB and JNK activation BCL10 APC PMC1160519__F6 Cardiac glycosides inhibit TNFA/NFKB signaling by blocking recruitment of TRADD to the TNFR TRADD TNF TRAF2 FADD PMC6111343__F7 MiR-146a-5p in the Toll-like receptor signaling pathway CD14 CTSK TLR9 CD6 IL9 TRAF3 TRAF6 IRAK4 RAC1 TNF TLR3 CPO TLR4 LBP CD40 FADD TIRAP PMC6050918__F8 Proposed model for CaSR activation of NCC through a PKC-WNK4-SPAK pathway CALU KLHL3 DCT ELL PMC8807488__F3 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor DGCR8 FOXP2 TCF7L2 CCND2 PMC8807488__F4 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor SUFU GLI3 RELB PMC6468893__F10 Dual prey-inactivation strategy of the venom of C KCP PMC5397035__F12 Lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement BTK PAK1 SYK PMC7207242__F1 Complement activation pathways and viral evasion of the complement cascade HEL-S-62p CD59 C9 CD55 VCP C4A CP PMC6361575__F3 Smad3 linker phosphorylation negatively regulates transforming growth factor‐B (TGF‐B)/Smad3 signaling EGF LEF1 HGF GSK3B SMAD4 SP1 FOXC2 PMC4929323__F2 Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury ERBB4 ERBB3 LIF NRG1 RHO MTOR STAT3 PMC12035889__F4 Mechanism of trained immunity and related research TLR4 IGF1R MTOR NOD2 PMC7402325__F3 An ambivalence model of PI3K/AKT/SOX2 signaling and DNA damage control in various stem cell conditions BAD SOX2 CDK2 MDM2 PTEN BAX PMC2867412__F2 Proposed role for AMPK in the kidney in coupling catabolic pathways requiring ATP hydrolysis (primarily sodium transport) with metabolic pathways leading to ATP synthesis (primarily fatty acid and glucose oxidation) EEF2 MTOR CFTR PMC12035889__F2 Signaling pathways inflammation and oxidative stress induced by LPS, HIS, iE-DAP and MDP CD14 TLR4 NOD1 LBP TNF MTOR NOD2 PMC8326121__F6 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives APC EGFR PMC7402325__F1 The canonical PI3K/AKT pathway with indication of key stimuli and central output functions BAD SOX2 CDK2 MDM2 PFKFB2 PTEN RPS6 TGFA HK2 BAX PMC7402325__F2 PI3K/AKT pathway is a superordinate module of SOX2 and p53 expression control SOX2 MDM2 PTEN BAX PMC8326121__F1 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives NONO RING1 RAD51 PMC7796211__F1 P53 network and metabolism DKFZp781B1423 E4F1 MDM2 BMI1 PMC7796211__F2 BMI1, ARF, MDM2, MDM4, E4F1, and p53 proteins shuttle between different subcellular compartments where they control different metabolic functions DKFZp781B1423 ATF4 E4F1 MDM2 BMI1 PMC8156237__F4 Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression? HLA-E CYBA INS MAPK14 PTEN TNFSF13 TCF12 MTOR FLT1 TAP2 GC CRP LEPR CD14 MAP3K1 RUNX1 FOS HLA-DOB NUP214 VEGFA IRS1 RXRA TUFM NFKBIA LEP IGF1 GAB2 NFKB1 NRP1 AVP LAT PMC7796211__F3 Several metabolic pathways in which the different components of the p53 network are implicated, including glycolysis, Oxphos, amino acid, and fatty acid metabolism DKFZp781B1423 E4F1 MDM2 BMI1 PMC9075007__F8 Working model for the effect of SULF2 monoclonal antibody 5D5 on PDGFRBeta-YAP signaling in CCA SULF2 CCND1 TF PMC3916405__F1 Distinct Antiviral Responses in Pluripotent versus Differentiated Cells RNASEL RNASE1 TLR3 MAVS PMC3950678__F6 Causal gene network inferred from top discriminative modules at a significance level of 0.005 MTHFD2L HEL-S-182mP IDI2 DAO SHMT1 GPT UPP2 ACSS2 MYL7 MDH2 RXRB PDE11A AGXT HEL-S-70p DLAT PRKCI MYL10 DLD ACADSB DBT SYNJ1 GIG8 GLDC PPARG AMT PMC9934381__F11 Model of cGAS-mediated antiviral function in EV-A71, SVV, and FMDV replication TBK1 CGAS IRF3 PMC3579782__F6 Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy STAT1 COX2 IGF1 MYF5 STAT2 PAX7 IL6 MSTN JAK1 IL4 STAT3 PMC6487091__F3 Mechanisms involved in the prooncogenic activation of the NRF2/KEAP1 pathway BRAF KEAP1 MYC JUN PMC4869873__F4 Schematics of the inside-out signaling of integrin activation PLCB2 PLCB3 BTK c-fgr VAV1 GSK3A ARHA SYK JAK3 PIP5K1C PMC4436788__F12 Proposed model of arachidonoyl-CoA shunting in LPCAT3-deficient mice PC LPCAT3 LPA TG PMC7940512__F1 BM-resident CD69+regulatory T cells (CD69+ Treg) decrease expression of CD39 which is required for the canonical CD39/CD73 adenosine pathway PC CD160 TIGIT LAG3 CD69 PMC6719876__F3 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences FOS TGFBR1 MAPK14 CACNA2D4 CRK MAP2K6 CRKL GNG12 TAOK2 MAP4K2 PRKCA NLK CACNG4 MAX MAP4K3 STK4 GRB2 JUND PC4 BDNF AKT3 PMC6719876__F4 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences CAMK2D BTRC FOSL1 FZD4 FBXW11 FZD5 CCND2 PRKCA NLK PLCB4 EP300 PPP2CA PPP2R5E PC4 CSNK2B PMC2729995__F1 Apoptosis and the main anti-apoptotic molecules: Binding of death receptors (Fas, TNF-R, TRAIL-R) to their ligands (Fas-L, TNF, TRAIL) initiates the extrinsic apoptotic pathway TRADD BCL2 TNF FADD PMC7196481__F3 Expression profiling of winged and wingless destined pea aphid embryos implicates insulin/insulin growth factor signaling in morph differences EGF ATG12 EGFR RAG1 INS SMAD4 PTEN CCNG2 RAG2 INSR NLK IGF1 ATM CDK2 MDM2 GRB2 IL7R FOXG1 KLF2 BNIP3 SKP2 PMC11311808__F2 Genetic and Signalling pathway dysregulation in AC NF2 SMAD2 APC SMAD4 LATS1 LATS2 PMC9541233__F1 Are UMFA (un‐metabolized folic acid) and endocrine disruptor chemicals (EDCs) co‐responsible for sperm degradation? An epigenetic/methylation perspective DHFR SLC46A1 SLC19A1 PMC3376184__F3 Function network built upon genes selected from the identified genetic component CAMK2D FOS FLNA PPP2R2C TRAF3 HTR7 GABRA4 GABRG3 DRD3 ERBB4 AGA GRIN2B BDNF CAMK2A CP PMC5861586__F2 Biological pathways whereby PM2.5 promotes cardiovascular events TLR4 TBP ARC RHO TNF PMC3517092__F1 Schematic depiction of the role of the retromer complex in mediating endosomal protein sorting VPS35 RAB7A SNX3 SNX27 VPS29 PMC9503294__F2 Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity CD207 AHR DSG3 STAT3 PMC7219856__F1 Interactions between the renin–angiotensin–aldosterone system and coronavirus Disease-2019 ACE2 ADAM17 TMPRSS2 PMC4177847__F4 Comparative Transcriptome Analysis Reveals the Genetic Basis of Skin Color Variation in Common Carp ASIP DCT TYRP1 MC1R WNT5B SFRP5 FGFR2 PMC7167370__F8 Possible mechanism of miR-519d overexpression in HCC MTOR DKFZp686F0183 RAB10 BAX PMC11724471__F1 KRAS proteins and metabolic pathways affected by oncogenic KRAS mutation GOT2 FADS2 FADS1 ACLY MTOR HK2 FASN CD36 PMC7398104__F5 TGFB1 pathway activation is reduced following RYGB ROCK2 IL18 AHR ID4 FOXM1 GREM2 TNF CSF2 TGFB1 PMC5801739__F2 Aberrant mTOR Signaling and Disrupted Autophagy: the Missing Link in Potential Vigabatrin-Associated Ocular Toxicity? SOCS3 VEGFA RHEB FKBP1A MLST8 GABBR2 GABBR1 PRKCB ABAT MUC5AC GABRE GDNF PSMB8 GRM6 STAT3 PMC8396471__F2 Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players MMP7 AIP SMAD2 CD163 SHH TNF PMC6904873__F6 PGP-mediated metabolite repair maintains flux through glycolysis and the pentose phosphate pathway GLO1 PGP HEL-S-162eP PMC5214458__F1 Schematic demonstrating the signaling networks and their cross talks involved in differentiating the mesenchymal stem cells (MSCs) into osteoblasts RUNX2 MSC LRP5 LRP6 RHO PMC9649847__F1 Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury TLR4 MYD88 TIRAP PMC10419152__F1 MAPK signaling pathways in mammalian cells: The MAPK signaling pathways are mediated by highly conserved MAPKs, which are activated sequentially TLR5 TLR4 MOS TRAF3 SRC TRAF6 ARHA MYD88 TLR1 TRAF2 CDC42 PMC10419152__F2 Mammalian MAPK pathways by effector proteins: This figure depicts the various components of MAPK pathways targeted by the bacterial effector proteins TRAF6 RHO RAC1 CDC42 PMC8547127__F1 Tipping the balance: intricate roles of the complement system in disease and therapy HEL-S-62p C4B_2 MASP1 C4A CR1 CD59 C9 FH C5AR2 C7 SEZ6 C6 CD55 C1S PMC8534108__F1 Metabolomic Profiling in Renal Cell Carcinoma Patients: News and Views BCL2 MTOR BAX PMC3785124__F7 Simplified network controlling the fate decisions between osteogenic and adipogenic lineages in huAFMSCs RUNX2 APC HEL-S-104 PMC8052156__F6 Active ingredient-target-pathway network IGF1R PTGS2 TNF NR1C1 PYGM HMGCR CDK6 CFTR MMP3 KDR CDK2 MCL1 PPARG SIRT1 PYGL PMC5292790__F1 Immune response in the polar clinical forms of leprosy NR1i1 CD163 CD209 LDLR LILRA2 PMC3769370__F8 Radioactive 125I Seed Inhibits the Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Triggering DNA Damage and Inactivating VEGF-A/ERK Signaling ATM CCNB1 VEGFA ATR PMC7795223__F1 Transcriptional AHR Signaling Pathway AIP AHR CYP1B1 SRC PMC7447759__F8 Functional annotation network FHL1 MAFF FOS GNG2 MYL2 TPM3 TNNC1 ATF3 CYFIP2 ATP2A2 CSRP3 CP PMC12028195__F1 DNA damage response (DDR) signaling pathway and DDR inhibitors used in clinical settings PML PALB2 WEE1 ATM BRCA2 RAD50 RAD51 ATR MRE11A BRCA1 CLK2 PMC7745059__F1 Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway TBK1 CGAS ENPP1 IRF3 PMC6280669__F2 Proposed TLR signaling network modified from previous reports (; ; ) CD14 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 RAC1 TLR1 CD40 CD80 IL1B TIRAP PMC3223826__F5 JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors ISG15 PTGIS HEL-S-28 CD44 HEL113 CSA2 MED27 HABP2 PMC12047224__F4 NFKB activation via the IKB degradation route is a common mechanism RIPK1 TRADD TRAF5 CYLD IRAK1 TRAF6 IRAK4 MYD88 OTULIN TRAF2 TAB3 PMC9179338__F3 Small but Powerful: The Human Vault RNAs as Multifaceted Modulators of Pro-Survival Characteristics and Tumorigenesis TFEB SQSTM1 PMC11988131__F3 Dual function of PHLDA3 as both an apoptosis inducer and inhibitor GPX1 PHLDA3 XBP1 SRXN1 PMC3221733__F3 Drosophila melanogaster as a model system for human brain cancers RICTOR CDK2 EGFR MYC CDK4 EIF4E PMC7401772__F6 Hypothetical scheme of the regulatory network underlying miR-19b targeted TSLP IL4 TSLP PMC6397564__F6 Critical roles of B3GalT5 and the globo-series GSLs in regulating the apoptosis and survival of breast carcinoma cells CASP3 EGFR CD44 hCG_1998026 FADD B3GALT5 PMC3959190__F3 Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights ZFR TPR MAL PMC9634082__F2 Ubiquitin modification in osteogenic differentiation and bone formation: From mechanisms to clinical significance OTUB2 USP4 USP26 TRIM16 RUNX2 RNF185 TRIM21 SMAD2 SMAD4 TRAF6 FGFR2 USP34 USP9X JUNB USP2 BMP2 SMURF1 FZD5 NEDD4 CBL CDC20 RELA SMURF2 APC2 SMAD1 SKP2 TRAF4 ITCH PMC9592993__F6 Integrating network pharmacology and experimental verification to decipher the immunomodulatory effect of Bu-Zhong-Yi-Qi-Tang against poly (I:C)-induced pulmonary inflammation ADORA2B CTSS TLR9 P2RX7 MYC NRAS IRAK4 BCL2L1 MMP3 PRKCA KDR NR1i1 KLK3 PTK2B SRC NTRK2 PLG FOS VEGFA IL8RB ADRB2 TNF HLA-A CDK2 CXCR4 NR1C2 ITGAV TH IKBKG NR3A2 PGR TGFBR1 EGFR NOX4 MTOR ADAM17 RARA TLR4 AHR F2 F3 BIRC3 SELE BAX RORC KIT PDGFRA FGF2 MMP9 PTGS2 IL6 NR1C1 HEL-S-162eP IKBKB EP300 LCK RELA SYK FLT3 CR2 PPARG STAT3 PMC6413120__F1 The MRN complex and the DNA-damage response ATM MDC1 RAD50 PARP1 MRE11A BRCA1 PMC4695904__F2 Oncogenic miRNAs involved in the apoptotic pathway PTEN BMF CIT BAX PMC10135105__F3 Activation of NRF2 signaling pathway by 4-HNE MAF KEAP1 PMC9145654__F5 TGFBeta-Treated Placenta-Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy SMAD2 SMAD4 HMGCR PMC4773776__F4 PKD2 and PKD3 support EMT and cell migration PAK4 PMC3166203__F10 Different ways to activate NFKB TRADD TRAF5 IRAK1 RELB TRAF6 SYK IRAK4 MYD88 TRAF2 TIRAP PMC6014919__F1 KRAS Activating Signaling Triggers Arteriovenous Malformations PIK3CA MTOR PMC5187938__F1 Proposed model of the role of KDM6A/B in definitive endoderm differentiation WNT3 DKK1 KDM6B PMC3166203__F12 Upstream kinases and redox-sensitive phosphatases in NFKB activation PI3 PTEN TNF PMC3166203__F13 Redoxosome formation in IL-1 signaling IRAK1 TRAF6 HEL-S-44 RAC1 MYD88 PMC7000593__F6 Role and pathway acquired by keratin, cytokines, and interleukins in horn SCC STAT1 TRAF6 IL6 PMC4628872__F1 The canonical and noncanonical regulatory pathways of Nrf2 signaling MAF GCLM KEAP1 DKFZp686F0183 PMC6311434__F7 Schematic molecular mechanism of SHH pathway regulation by HER2 in breast cancer cells GSK3B SHH PMC8630697__F1 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer TBK1 STAT1 CGAS STAT2 IRF9 IRF3 IFNAR2 IL6 IFNAR1 PMC4028786__F1 Homocysteine metabolic pathways PMC3356707__F1 Canonical WNT signaling pathway NLK APC CHD8 LRP5 CER1 LRP6 VANGL1 SOX17 PMC8802512__F2 The S100 protein family in rheumatoid arthritis CREB1 TIRAP PMC11935715__F7 Piezo1 promotes atherosclerotic endothelial inflammation in response to OSS VCAM1 PIEZO1 SRC PMC12229362__F3 Phosphoinositide compartment GPR161 INPP5E PMC4807419__F1 The transcriptional and posttranscriptional regulation of LDLR expression PCSK9 LDLR PMC2766052__F8 The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation TBK1 IRF7 TRAF3 IRF3 MAVS PMC8358777__F7 Exploring the Pharmacological Mechanism of Radix Salvia Miltiorrhizae in the Treatment of Radiation Pneumonia by Using Network Pharmacology TH ME1 BAD APP GAL FADD RBL2 RXRA CD19 PMC8265131__F8 Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways PTGIS ANXA1 FACL4 KEAP1 PLA2G6 PTGS2 ANXA3 ANXA4 ALOX5 LTC4S ANXA6 HEL-S-7 PTGS1 MAP2K6 PLA2G4B ANXA2 ACSL1 PLA2G5 ACSL3 PMC6465568__F2 Signal crosstalk in NFKB transcriptional regulation IRF3 IFNB1 MYD88 TNF PMC6481333__F10 Microarray and pathway analysis of two COMMA-DB derived clones reveal important differences relevant to their developmental capacity in-vivo E2F4 SMAD2 SMAD4 STAG1 CDK7 STAG2 CDC20 CDC6 SMC3 CDK2 MDM2 PCNA SKP2 MYT1 PMC3463893__F2 The inductive and effector sites for the mucosal B-cell response in CD PC BCR GC CD40 PMC6801762__F1 Schematic presentation of the metabolic pathway and transporters that regulate the cellular polyamine levels SMOX PAOX SLC3A2 SLC22A3 SLC22A2 SLC22A1 SLC12A8 PMC5585869__F5 BCR–ABL pathway drives signaling in H929 cells and phosphorylation is inhibited by imatinib NPAT BCR GAB2 SHC1 PMC4822708__F7 CD47 regulation of autophagy CD47 DKFZp686F0183 PMC2676108__F3 INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN EUKARYOTIC EVOLUTION AND DEVELOPMENT: A MODEL OF THEMATIC CONSERVATION TRADD RELA TRAF2 FADD PMC6148320__F2 Helicobacter pylori infection and inflammatory bowel disease NLRP3 ULK1 CDX2 HP TRAF6 MYD88 MUC2 IL1B NOD2 PMC5396125__F1 Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway BIRC2 NOD1 BIRC3 NOD2 TAB3 PMC2720375__F7 Genome-Wide Screen of Genes Required for Caffeine Tolerance in Fission Yeast HBA2 CCR4 ATF1 RAD51 TPP1 TF PMC4822708__F4 Functional crosstalk between CD36 and CD47 signaling CD47 SRC CD36 PMC5813732__F7 Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway NUMB FGF4 LEF1 TCF3 HGF CCND1 PMC3358449__F1 Key components in the regulation of methionine metabolism HEL-S-61p HEL-S-182mP MSRA PMC4133953__F8 Cell cycle regulation by miRNA and their targets dysregulated in cervical cancer CDK2 CCND1 CDK4 CDC2 FOXO1 CDK6 PMC4133953__F9 Network for miRNAs involved in migration and invasion of cervical cancer cells GALNT7 SEMA4D PLG SMAD2 ARHA SP1 PMC1618798__F2 Intrinsic apoptotic signaling pathway PROC BAX PMC1618798__F3 Extrinsic apoptotic signaling pathway TNF FADD PMC5763483__F3 Potential cascade of molecular events leading to reduced differentiation of regulatory T cells for prevention of autoimmunity CD93 FOXP3 PMC7375019__F1 Activation of RAGE axis in Sars-Cov-2 infected cells in DM patients NLRP3 HMGB1 DPP4 IL1B PMC9434547__F1 Lactate metabolism in human health and disease YTHDF2 ARG1 PMC7791181__F8 Working model of the target interaction axis after SCI After SCI, TGF‐B1 expression was increased, leading to phosphorylation of the Smad2/3 protein, thereby promoting miR‐21a‐5p upregulation SMAD2 PMC4631256__F2 Epigenetic Mechanisms in Schizophrenia REST BDNF PMC5462018__F5 Conserved ABA signaling pathway in epidermis of H MYB AVP PMC5247472__F1 Vitamin D metabolism FGF23 CYP2R1 DBP CYP24A1 PTH CYP27B1 PMC7938641__F1 Hypothetical concept for the dysregulation of lung epithelial ion and fluid transport by SARS-CoV-2 TRPV4 ACE2 CFTR NHERF1 PMC3524194__F1 Upstream regulators of the Hippo pathway LATS1 RHO LPA PMC8898834__F2 Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection PDC MTOR MAVS PMC4444031__F4 Illustration of the Hedghog (Hh) signalling activation NLK APC LRP5 LRP6 ARHA DKK1 JUN PMC3023296__F3 Cell cycle, cellular growth and proliferation pathways detected by ingenuity pathways analysis INVS FLCN HEL2 CDKN2A HNF4A CDC123 RPS27A DNAJB12 DISP2 GPR132 PEG10 CNOT3 VPS41 NFYB PMC8824735__F1 Structure-based discovery of selective CYP17A1 inhibitors for Castration-resistant prostate cancer treatment CYP11A1 CYP17A1 CYP21A2 PMC7655170__F9 Schematic mechanism underlying CUEDC1-suppressed NSCLC progression SMAD2 SMURF2 CUEDC1 PMC11983443__F1 Leptin and adiponectin in health and disease TH MTOR STAT3 PMC9061764__F3 Mechanism identified for ketamine and/or (2 R, 6 R)-hydroxynorketamine (HNK) NAMPT S1PR2 GIG8 ID4 MTOR ID1 ID3 PMC4619206__F4 MAPK signaling pathway in CNVRs unique to the susceptible line CD14 NGF MOS TRAF6 TNF NLK NF1 MAX GRB2 JUND ECSIT RAF1 BDNF TRAF2 MEF2C PMC10605254__F5 PDLIMs and TGFB signaling pathway SEMA3A SMAD2 SMAD4 ARHA PDLIM7 SMAD1 LMO7 DKFZp781O1323 PMC10605254__F6 PDLIMs and MAPK and NFKB signaling pathway PDLIM4 LIMK2 PDLIM2 PDLIM7 HEL-S-112 PDLIM3 LMO7 STAT3 PMC10605254__F4 PDLIMs and integrin signaling pathway PDLIM4 PDLIM2 PDLIM7 HEL-S-112 LMO7 PMC3539824__F2 Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders FYN NRP1 GSK3B CDK5 PMC8773595__F1 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma HNF4A FOXM1 PMC7370863__F1 VG9/VD2 T‐cell response to microbial antigens and self‐phosphoantigens—the little things that give it away IPP BTN2A2 BTN2A1 PMC4265312__F2 TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis IL16 SOX2 ASCL1 PAX2 WNT7A PTEN POU5F1 BMP4 PMC8773595__F2 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma APC GSK3B LRP5 LRP6 TCF4 PMC8734057__SF1 Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19 TNF ACE2 ADAM17 PMC2089068__F3 Relative transcript levels for genes from carbon central metabolism for PB12 (first value) and PB13 (second value), as compared to JM101 SDHC CIT TNLG7C RPE SDHA MAL SDHB GALP PMC5833436__F8 miR-146a-5p and TLR4 signaling TLR4 IRAK1 SMAD2 TRAF6 MYD88 PMC2089068__F4 Relative transcript levels for genes from carbon central metabolism for L-Phe overproducing strains SDHC RPIA CIT TNLG7C RPE SDHA MAL SDHB GALP PMC3810677__F1 Regulation of the HIF pathway by oxygen dependant and independent mechanisms (a) Under normoxia, prolyl hydroxylase domain proteins use oxygen and Alpha-ketoglutarate as substrates to hydroxylate conserved proline residues on HIFA subunits EDN1 ANGPTL4 VHL MTOR PMC7243250__F6 Signaling pathway of Bak’s neuroprotective effect against SAH injury which is suggested in the present study MMP9 TXNIP BAX PMC5755503__F2 Genetic alterations that lead to HIF activation in GBM TH EGF EGFR MDM2 PTEN MTOR PMC12129981__F1 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review TBK1 CGAS IRF3 TNF PMC12129981__F2 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review TBK1 NLRP3 CGAS IRF3 PMC11617312__F3 Canonical Wnt/Beta-catenin signalling in epithelial homeostasis and HPV-modulated homeostasis SIAH1 APC NHERF1 PMC10342868__F8 Regulatory mechanism of lncRNA 220 PIK3R1 TLR4 PIK3CA MYD88 MTOR PMC8695500__F2 Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke TH TSC2 CD14 ULK1 BAD TSC1 CXCR4 GSK3B STK11 CSA2 CXCL12 BAX PMC11591885__F2 Leu supplementation leads to tumor cell death by inducing apoptosis and oxidative stress IDO1 IGF1 PMC8146072__F5 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation PTEN HEL107 RPE PMC11591885__F1 Action of Leu and its metabolites SLC7A5 TSC2 RPS6KB1 TSC1 BCAT2 TBC1D7 SESN2 EIF4EBP1 PMC4811915__F9 Proposed model for the role of the Wnt/Beta-catenin pathway during odontogenesis DKK1 BMP4 PMC9963318__F3 MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis MED25 POLL POLI PMC8329443__F3 Vital Roles of LINC00662 in Human Cancers LATS1 FRMD6 PMC6628350__F8 Liraglutide attenuates diabetes-associated neointima formation and pathogenic EndMT via the AMPK pathway SMAD2 IL1B PMC4561307__F8 The changes in soleus muscle gene expression within the TGFB and BMP pathways, with SCI (a) and acute response to treadmill training (b) FST SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC8327397__F6 Sphingolipid metabolism and the enzymes directly participating in the ceramide synthesis pathway AHR DES CERK SMS PMC7458277__F5 Interaction network derived from the pathway analysis according to results of the genome-wide association study [GWAS] meta-analysis NOTCH4 XPOT HRH2 ST8SIA4 NCAM2 CACNG3 PLCG2 NUP210 CEBPG SPRY2 SLC2A4 MC2R DVL2 CD40 COMP RPS6KA2 EPHA4 TRIO PMC8329443__F2 Vital Roles of LINC00662 in Human Cancers ATF2 HEL-S-79 IL22 RHO CDC42 PMC8717932__F1 Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases CASP3 CAP1 ATG3 TRAF2 FADD MLKL GSDMD BAX PMC6499473__F1 A Developing Therapeutic Decision Tree for Ductal Breast Cancer with Emphasis on the TNBC Subtype PI3 CDK4 CDKN2A CDK6 PMC11873181__F2 Regulation of mitochondrial quality control by PGAM5 APC LRP5 LRP6 PGAM5 PARL PMC7226287__F8 BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma KEAP1 BMP8A TRIM24 PMC7467727__F5 MTOR regulation of oRG morphology MTOR CP CDC42 PMC6941425__F6 Targeting citrulline-specific B-cells using a CCP-STAL BCR CD22 CP PMC4949115__F2 M2a polarization TYK2 JAK3 JAK1 IRF4 PMC9094111__F1 Calcium Mediated Cold Acclimation in Plants: Underlying Signaling and Molecular Mechanisms MYC CBL PMC5795461__F1 Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses NLRP3 TLR8 TLR7 TLR4 IRF7 IRF3 TLR10 NOD2 TLR3 PMC5113305__F1 Molecular mechanisms supporting the proliferation of HCC cells despite serum withdrawal OXCT1 HMGCL BDH1 HMGCS1 SP1 PMC8441304__F6 SUMO‐mediated DNA replication‐independent DPC repair SPRTN RNF4 TRAIP PMC8927970__F1 Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TRAF2 TIRAP TAB3 PMC8185231__F1 Vitamin D: Possible Therapeutic Roles in Hepatocellular Carcinoma AFP HDAC2 TXNIP MTDH STAT3 PMC9231436__F2 Next-Generation Anti-Angiogenic Therapies as a Future Prospect for Glioma Immunotherapy; From Bench to Bedside EGF PIN1 BAD HGF EGFR APC GSK3B LRP5 LRP6 RHO HIF1A FLT3LG PIM1 COX2 F2 MDM2 CASP9 KITLG CCND1 CDK4 FLT3 GAL TGFA PMC8359396__F1 Pharmacological validation of TDO as a target for Parkinson’s disease HAAO HEL-S-90n KYNU KMO PMC5654107__F5 Model of metabolic processes upregulated in aerial and in root cells PGM2 PCK1 FBP1 ACO2 ARG1 NOM1 HEL60 TF CP HEL-S-4 THRA HES1 PMC3931120__F7 In Utero Exposure to Second-Hand Smoke Aggravates the Response to Ovalbumin in Adult Mice CXCL13 CCL24 VCAN CCL7 SELP SAA1 TOP2A CP PMC6139224__F6 Diseases and functions analysis by integrated pathway analysis using 20 MeDEGs NFE2 RUNX3 F2R PLAUR CTSO C3AR1 PAG1 CTSZ CTSG FYN SPI1 PRF1 ELANE PRKCH LTBR PMC6195682__F4 Cytokine/chemokine driven JAK-STAT pathway in transgenic spleen HLA-E CCR2 CTSS CCR3 CSF3R CCL7 CCL2 BMF C4A OSMR MX1 PIM1 GBP1 TAP2 GBP2 GHR SRC C1S PSMB9 CD14 IRF7 FOS IRF9 CXCL10 DDB2 BCL6 IDO1 GRK4 IL7 LYN IL6ST CCL3 PMC5789890__F3 Representation of the DNA methylation modifications that occurred within the PI3K/AKT KEGG pathway following 7 weeks of reloading in human subjects ME1 TSC2 BAD TSC1 BCR MDM2 PTEN MTOR PMC3615616__F1 Self-renewal and differentiation of gastric stem cells EGF FOXQ1 ARF1 PTHLH CALM1 MUPCDH FOV TFF2 MUC5AC TFF1 MUC6 PGC FADS1 IGFBP2 SHH PMC6491463__F3 Schematic depiction of the CD38/CD203a/CD73 adenosinergic pathway as a major mechanism of the acquired resistance to anti-PD-1/PD-L1 blockade within the BM niche RARA PMC6491463__F1 The purinome in the MM environment under bone marrow niche metabolic reprogramming ADA HEL-S-133P PMC3888787__F1 Bile acid synthesis occurs by two pathways, the classic ‘neutral’ pathway and the alternative ‘acidic’ pathway CYP27A1 AKR1D1 CYP7A1 HSD3B7 PMC5691655__F1 DNA damage repair (DDR) factors regulate cccDNA formation, expression, and degradation POLK SMC6 SMC5 PMC5691655__F2 HBV components interact with DDR pathways and proteins SMC6 DDB1 OGG1 SMC5 PMC3383804__F5 HCMV management of the PI3K/AKT/mTOR pathway TSC2 RICTOR TSC1 EIF4E RHEB PMC8540355__F1 Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases TBK1 CGAS TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 MAVS PMC9266881__F2 Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression SMAD2 EGFR IL8RB CA3 MTOR TRPC4 TRPC1 HEL-S-11 TRPC5 TRPC6 ORAI1 STIM1 STAT3 PMC8507780__F10 Alterations in HLA Class I-Presented Immunopeptidome and Class I-Interactome upon Osimertinib Resistance in EGFR Mutant Lung Adenocarcinoma ERAP1 HEL-S-269 HEL-S-99n STX16 ATG2A LNPEP B2M VPS37B PSMB9 PSMB10 PMC9316990__F3 Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases ATM MDC1 ATR PMC8065041__F10 This study CD163 NOS2 STAT3 FOXP3 PMC8144465__F4 Cannabidiol Modulates Mitochondrial Redox and Dynamics in MCF7 Cancer Cells: A Study Using Fluorescence Lifetime Imaging Microscopy of NAD(P)H TRPV1 BAX PMC7672029__F4 Flowering and sex determination metabolic pathways: identification of candidate genes underneath the QTLs CRY1 F11 TF AGL PMC5719056__F1 The mevalonate pathway leads to cholesterol synthesis FDPS FDFT1 HMGCR PMC9463773__F1 Diversification of PAR signaling through receptor crosstalk APC RHO RAC1 PMC9463773__F2 Diversification of PAR signaling through receptor crosstalk EGF COX2 TLR4 COX1 SMAD2 TGFBR1 SRC IRF3 RHO CA12 PMC4588110__F1 PI3Ks signaling during G2/M progression and mitosis phase PLK1 APC CDC2 PMC5596340__F5 Metabolic reconstruction of the candidate phylum members PAUC34f, Parcubacteria (OD1), Peregrinibacteria, and ACD39 (Bin 13) TH SHE PMC7157488__F1 Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication TBK1 METTL14 TLR4 STAT2 EIF2A IRF3 ALKBH5 TLR3 MAVS PMC2615542__F2 Luteolin, a flavonoid with potentials for cancer prevention and therapy RELA FADD BAX PMC3880642__F1 Smoking and microRNA dysregulation: a cancerous combination FHIT EGF ADAM8 BAD EGFR GSK3B MYC ARHA PTEN HIF1A MTOR SLIT2 RDX PAH ADAM17 CDK6 TLR4 ZEB2 MDM2 SRC TGFA SKP2 HOXD1 PMC8994563__F7 Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment BLOC1S5 PMEL MLPH PNMT DTNBP1 RAB27A MSRB3 MC1R SOX10 ACHE PAX3 UVSSA PMC4111847__F4 Glycolysis and the triacylglycerol biosynthetic pathway in Cp0710 MCAT HEL-S-162eP PMC6624447__F5 Canonical pathways generated in Ingenuity Pathway Analysis of interferon signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi IFIT3 STAT2 IRF9 CAST IFITM2 FITM2 PSMB3 PIAS1 TYK2 JAK1 IFI35 PSMB8 SOCS1 IFIT1 BAX PMC6624447__F6 Canonical pathways generated in Ingenuity Pathway Analysis of Oncostatin M signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi MMP3 MT2A TIMP3 GRB2 OSM CHI3L1 OSMR PMC6769697__F1 Schematic depiction of copper and platinum distribution in tumor cell ATP7B COX17 ATP7A ATOX1 HEL-S-44 CCS PMC9100382__F3 Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies HMGB1 SIRT2 GULP1 SIRT6 MEGF10 ABCA1 GPC6 SIRT1 STAT3 SIRT3 PMC3159179__F4 Methionine-Hcy metabolism PMC6315366__F4 Autophagy, Keap1 and p62 regulate Nrf2 in HCC TBK1 ULK1 KEAP1 MTOR PMC3699421__F2 Reactivation of HIV-1 transcriptional latency SUV39H1 EZH2 HEXIM1 PMC2593508__F8 Fasudil inhibits the myogenic response in the fetal pulmonary circulation GC ARHA RHO PMC5394422__F2 The autophagy pathway and core autophagy proteins ULK1 ATG12 ATG3 LAMP2 AMBRA1 ULK2 ATG10 DKFZp686F0183 WIPI1 WIPI2 UVRAG STX17 ATG14 PMC9569062__F5 Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies NPS PMC9374593__F8 Working model that PFKFB3 inhibition plays an important role of deregulating cancer stemness, EMT and chemosensitivity in small cell lung cancer SOX2 NF2 F2 CD44 LATS1 ABCG2 PMC8236950__F5 Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients ACE2 TMPRSS2 STAT3 PMC5011664__F3 Regulation of wingless/int-1 signaling by crosstalk in hepatocellular carcinoma HGF IGF1 GSK3B SPTBN1 SMAD4 CCND1 AXIN2 PMC5386661__F10 Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance MBP GFAP IBSP BMI1 OLIG2 PMC9058112__F1 Cardiac Remodeling in Heart Failure: Role of Pyroptosis and Its Therapeutic Implications NLRP3 NLRC4 NLRP1 NLRP6 AIM2 IL1B NLRP9 GSDMD DFNA5 PMC8165101__F5 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives SUFU PTCH1 GLI3 SMO PMC8226042__F1 Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis IL10 IL6 TNF ACE2 PMC8165101__F6 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives BIK BAX PMC8165101__F7 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives CHEK2 PALB2 ATM RAD51 ATR CHEK1 PMC3224542__F1 Genes related with the tau protein phosphatase-2A (PP2A) pathway PIN1 LCMT1 PPP2CA PPP2R2A PMC3394960__F10 A schematic model for the role of ANXA2 in the pathogenesis of adenomyosis ANXA2 VEGFA PMC2933174__F6 Model depicting a novel mechanism by which cetuximab induces autophagy EGF BCL2 MTOR PMC3317440__F2 Strain-specific host gene networks activated in Mtb-infected BMM EGF HBEGF ITGA4 HDAC1 NR1C1 IL12RB1 STARD4 CISH PTK2B CCR7 CCND1 JAZF1 PPARG MECR STAT3 PMC3174390__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC9503046__F4A Antimicrobial Peptides and Biomarkers Induced by Ultraviolet Irradiation Have the Potential to Reduce Endodontic Inflammation and Facilitate Tissue Healing MMP10 EGF MMP9 FGF2 EGFR SNAI2 MAP3K7 TRAF6 HBEGF RAC1 TNF FGFR2 CEBPB IFNG PRKCA MAP2K1 MAP3K14 RAF1 CSF2 TGFA TRAF2 FGF7 PMC11607510__F3 Glucose metabolism reprogramming of VECs GCKR PIM1 VCAM1 F2 HEL-S-133P HK2 PMC7267399__F2 Possible life cycle of SARS‐CoV‐2 and potential intervention strategy ACE2 TMPRSS2 HEL-S-69p PMC3174390__F4 Inhibitory role of Smad7 in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC11607510__F4 Glucose metabolism reprogramming of VECs in atherosclerosis TIGAR VCAM1 ROCK1 LDLR PRKAA1 ARHA CDH2 MTOR DKFZp686F0183 SIRT3 PMC6850169__F1 Simplified lipid metabolic pathway in maize OGA PGP LPA PMC6748048__F1 Kinase Activation Mechanisms in the Hippo Kinase Cascade FGFR1OP2 STRN NF2 SLMAP PMC4463932__F2 Glycosylation pathway defects with known immunologic consequences CCR5 SLC35A1 ALG1 JAGN1 PGM3 G6PC3 ALG12 GCS1 SLC35C1 PMC6748048__F3 Upstream Regulators of the Hippo Pathway in Drosophila and Mammals HEL70 AMOT HEL-S-28 VGLL4 SCRIB RHO MYD88 LATS2 PATJ NF2 INSM1 PALS1 APP SRC CRB3 PMC6748048__F4 Hippo Pathway Mutations in Human Diseases GNA11 NF2 LATS1 LATS2 PMC6506890__F4 Mevalonate Pathway ACAT1 IDI2 FDPS MVK IDI1 HMGCS1 GGPS1 HMGCR ACAT2 PMC11577197__F1 CD8+ T cell differential hierarchy upon antigen exposure CCR7 KLRG1 TIGIT TOX CD69 PMC7005447__F5 Proteomics-guided metabolite supplementation strategy for arRP CS HEL-S-30 ENO1 PFKL HEL-S-32 HEL-S-26 PDHA1 ACO2 SUCLA2 OGDH SDHA HK2 FASN PMC11577197__F2 Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis CD37 CD80 TIGIT TOX IRF4 BATF PMC9519863__F2 Gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis NLRP3 IL18 CYP8B1 TLR4 FGF19 IL8RB CXCL2 MYD88 SPHK2 PMC8834247__F4 Put in a “Ca2+ll” to Acute Myeloid Leukemia CXCR4 CXCL12 HIF1A PMC8834247__F5 Put in a “Ca2+ll” to Acute Myeloid Leukemia ZAP70 CD80 IRF4 IFNG BATF PMC3721836__F9 Simplified model of Rac1 signaling and function in learning-induced adult neurogenesis GADD45B RAC1 BDNF JUN PMC8834247__F3 Put in a “Ca2+ll” to Acute Myeloid Leukemia PML HEL-S-26 MFN2 ATM KDM2A PTEN MTOR ORAI1 FADD BAX PMC4367602__F2 Ligand stimulation of ERK and PI3K signaling in BRAFV600E melanomas EGF HGF BRAF EIF4E SPRY2 PMC8081956__F3 Autophagy in Hepatic Steatosis: A Structured Review ULK1 ATG12 ATG3 KEAP1 ATG101 ATG10 ATG14 DKFZp686F0183 PMC2878851__F3 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures SPARC APC PTEN E2F3 AURKB CCNE1 TSG101 STAT1 MCM3 CREBBP PSMD12 MMP2 MAP4 CCNB1 MCM10 GINS2 EN1 PCNA PMC6023743__F1 A well-studied example of modulation of phospholipid signal transduction cascade in the nucleus is turnover of inositol phospholipids, especially phosphatidylinositol-4,5-bisphosphate (PIP2) PLCG1 PC PLD2 LPA PLCB1 PMC5910322__F6 Pro-apoptotic mechanisms of miR-217-5p regulating the ERK-MAPK pathway at different sites PRKCI BAD SOX2 BRAF BAG3 GRB2 BCL2 MAPK1 ITGAV RAC1 BAX PMC1635984__F3 MRNA expression levels in TGFBeta-treated T84 epithelial cells compared to control cell culture EGF SOS2 IGF2 EGFR APC RRAS SKP1 FZD4 PTEN RBX1 NLK CREBBP LEF1 IGF1 WNT4 GRB2 DVL2 MAPK1 GRB10 SOS1 PMC9335290__F2 CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases PC CCND1 PTEN CDH2 MTOR FOXK2 HOXB13 ITCH BAX PMC2878851__F1 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures MAF SPARC MCM3 CDC20 CDKN1A APC CCNB1 NEK2 PTEN PMC7797150__F4 Prediction of target genes and circRNA-miRNA-mRNA network DGIC ZBTB7A ID4 RTP4 COLEC12 IKZF3 MED17 SLC24A4 ACVR2A TGFBR3 TP53RK RMND5A PYROXD1 SLC30A9 ANKRD49 ZFP3 PPP1R1A VPS13D SOS2 RFX3 GAPVD1 VGLL4 FRMD3 RAB31 SYNPO2L TMEM33 TGIF2LX TGIF2LY CDC42EP1 DNAJC9 ADNP SEC22C DCTN5 KMT2A STAU1 INSIG1 NUFIP2 SLC41A2 VCAM1 TGFBRAP1 ACVR1B STK4 TGIF1 GLG1 PPP2CA MLLT6 ARHGAP21 SNX4 TGFA SYNGR1 GRPEL2 ZNF549 C10orf104 TAB3 MLXIP MCTS1 ZFHX3 SPAG7 SYNRG SEMA4C TGFBR1 ORMDL1 TGFBR2 UBE2G1 PXDN ELP3 SSH2 SFRS3 NABP2 GJB7 FSTL3 YTHDF1 ARPP19 RRM2 SFRP1 EPHA4 RGS4 SUI1 DDX3X NRBF2 MAP3K7IP1 FUS PMC3874316__F7 Antcin C-induced upregulation of antioxidative gene expression via the Nrf2/ARE signaling pathway and suppression of AAPH-induced apoptosis in human hepatic HepG2 cells MAF KEAP1 APAF1 BCL2 NQO1 BAX PMC6381446__F2 Schematic representation of the role of oxysterols in the Hh signalling pathway PTCH1 SHH SMO PMC2686735__F5 Map of BCR-pathway BAD VAV1 GSK3B SHE PTEN RAC1 HRAS MAPK13 BASH BIK LYN GRB2 CDC42 PMC7308426__F5 Calcium signaling pathway PLN BCR DAO CAV3 STOM ALB MCU ORAI1 PMC7308426__F6 Pathway in cancer RARA PTEN PMC5814934__F6 Working model RBPJ NOTCH1 BRD4 PMC9146014__F1 Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses CDA UCK2 UMPS CAD DHODH CMPK1 PMC5977747__F2 Possible scenarios for PanDrugs therapeutic candidates EGF HGF EGFR MTOR PMC8980477__F1 Contribution of Interleukin-17A to Retinal Degenerative Diseases TRAF5 EBP TRAF6 IL17RB TRAF2 IL17RC TRAF4 PMC5997132__F4 Main pathway targeted using siRNA delivery systems in oral cancer.Notes: Examples of siRNA therapeutics alter multiple hallmarks applied for oral cancer CD47 ANGPTL4 BAG3 CIP2A CXCR4 HAS2 SOX4 PMC3823960__F6 Summary of retinoid pathway CYP26A1 LRAT CYP26B1 HEL111 PMC9671909__F6 Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models TH IKBKAP PMC8347567__F10 Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGFB1 Signaling Pathway STAT3 PMC3607680__F3 The one carbon cycle PMC5080925__F6 Model showing association of PAX5, CD19, CD3, p53, Ras, Raf, MAPK and Zap70 in B-cell and T-cell type non-Hodgkin's lymphoma PAX5 ZAP70 CD19 PMC4292048__F3 TRAF4 function on TJs USP15 SMURF2 ARHA SMURF1 TRAF4 PMC6078642__F7 Enzymes necessary for local aldosterone synthesis are present in muscle-derived leukocytes CYP11A1 STAR CYP11B2 PMC6763548__F1 Scheme illustrating the actions of adiponectin/AdipoR agonist, AdipoRon, in the liver and the muscle ADIPOR1 ADIPOR2 NR1C1 SIRT1 HEL60 UCP2 CAMKK1 PMC3439965__F3 Simplified overview of the canonical Wnt signaling pathway APC DKK1 FRZB PMC4118716__F2 Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis STAT4 TYK2 JAK3 JAK1 IL1B GATA3 STAT3 PMC7879595__F2 Among P2X receptors, the P2X7 is highlighted within the context of BC CD44 ELL PMC7879595__F1 The TME of solid tumors has the common characteristic of hypoxia (1% O2), which is due to a low supply of nutrients and oxygen BCL2 BAX PMC5514966__F4 Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target SET NOTCH1 RAF1 EZH2 STAT3 PMC3390960__F1 Formation of the COPII vesicle on the surface of the endoplasmic reticulum SAR1A SEC24C SEC23B SEC31B SEC31A SEC23A DKFZp434B2017 PMC3417062__F7 Molecular mechanisms underlying PA and histologically anaplastic PA NF1 BRAF EGFR PTEN RAF1 PMC7923229__F3 TRIM5Alpha-mediated regulation of innate immune signaling and molecular inflammation ULK1 TLR4 TRIM50 TRAF6 TAB3 PMC9237441__F5 Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities BAD APAF1 BCL2 AXL STAT3 BAX PMC6054220__F2 Autophagy induced by nutrient and nutrition stresses via the mTOR and AMPK signal pathways TSC2 MTOR DEPTOR RHEB MLST8 PMC4218725__F6 Shigella dysenteriae Modulates BMP Pathway to Induce Mucin Gene Expression In Vivo and In Vitro CDX2 MUC5AC SMAD4 MUC2 PMC5527897__F2 N‐linked glycosylation ALG1 ALG3 ALG8 MGAT3 ALG13 SLC35A3 ALG6 ALG10 MGAT2 PMC4051845__F1 DNA double-strand break repair pathway choice and cancer RIF1 BARD1 BRCA1 PMC8268913__F6 Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia NF2 LATS1 PMC8365911__F4 Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants NDRG2 CD9 MYC HEL-S-2 CNTFR PTMA IGFBP7 ENG GADD45A LAMA3 MCM3 GGT7 IGFBP4 TYRO3 PRKAG2 KLF2 IGFBP6 AKT3 CDA ADAM12 FRZB AOX1 AMFR TLN2 STC2 HEL-S-111 RPL10A HOXA10 CTBS RPS12 RHOB TSPYL2 P3H2 ARHGAP10 KAT2B BBS10 MAFB DAAM2 SLC25A5 AEBP1 SLC7A1 HEL-S-34 THSD4 PTGES WASF3 EHD3 RIOK3 RCC2 PBX1 ESYT2 HEL-S-162eP NFKBIA RGCC MBIP HEL-S-29 PMC5527897__F5 Ganglio‐series glycosphingolipid synthesis pathway UGCG B4GALNT1 ST3GAL1 ST8SIA1 B3GALT4 ST6GALNAC6 PMC4118716__F4 M1 and M2 macrophage polarization CXCL10 CCL17 CCL2 CCL18 CCL22 IL1B PMC2712666__F3 TNF superfamily: costimulation and clinical applications PI3 CD27 TNLG8A TRAF2 PMC7607850__F1 ZA inhibits the RANKL/RANK pathway NFATC1 TRAF6 MTOR PMC5509628__F2 Cav1.2 and Cav1.3 signaling mechanisms EIF2A CA12 PMC4811021__F1 Diagrams of the Hippo signaling pathway in (A) Drosophila melanogaster and (B) mammals highlight the core kinase cascade and upstream regulatory signals LATS1 PMC7855207__F1 Expanding the Clinical and Metabolic Phenotype of DPM2 deficient Congenital Disorders of Glycosylation DPM1 DPM2 DPM3 PMC9639813__F6 Key neuronal signalling pathways are downregulated in fast growing in vivo juvenile liver fluke POR SYP PMC9602136__F14 Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells ME1 PLTP PMC7762867__F1 Inflammatory signaling pathway in macrophages TLR4 IRAK1 NFKB1 IRAK2 RELA TRAF6 IRAK4 MYD88 TNF MAL PMC2847521__F11 Proposed model for the I3C disruption of a cross-regulatory positive feedback loop involving expression of GATA3 and ERA by stimulating the degradation of ERA protein AHR RBX1 GATA3 PMC5777301__F1 Type I Interferon signaling pathway STAT1 ISG15 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 USP18 PMC6349473__F2 Developmental processes regulate craniofacial variation in disease and evolution RUNX2 SUFU TWIST1 SMAD6 SHH SMAD4 SMO TCF12 PMC11820753__F3 Impact of CR on different nutritional pathways indicating how it promotes anti-cancer activity TSC2 TSC1 IGF1R IGF1 MTOR RHEB PMC6874456__F8 Schematic model of how TG NPs ameliorate CKD progression NPS TG PMC3670604__F4 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma HEXA HEL-S-99n VEGFA TNPO1 HEL-S-87p LMNA H2AX CLU PMC1415320__F6 The proposed TGFB1 signaling mechanism that promotes EMT SMAD2 GSK3B SMAD4 PMC3124345__F2 Schematic representation of the possible mechanisms leading to ovarian cysts in female patients with ORD POR CYP17A1 CYP51A1 PMC7708424__F5 An example of where Pascal pathway enrichment and HotNet2 home in on the same pathway causal of Hyperlipidaemia SORT1 APOA4 LIPC SCARB1 MYLIP APOC2 APOC1 APOC3 HNF1A MTTP PCSK9 APOB VLDLR ABCG1 LPL LDLR ABCA1 APOA2 APOE PMC9386081__F1 Non-coding RNAs in necroptosis, pyroptosis, and ferroptosis in cardiovascular diseases NLRP3 GPX4 TRADD RIPK3 MLKL GSDMD DFNA5 PMC4778854__F3 Changes in the expression levels of genes associated with cell cycle pathway in PC3 cell line after treatment with G EFS PTTG2 APC PRKDC CCND2 PMC11566483__F4 Caspase-3/8/9- and granzyme-mediated pathways RIPK1 GZMA RIPK3 TNF GSDMC FADD GSDMB GSDMD BAX DFNA5 PMC8699546__F6 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation HMGB1 TLR4 MYD88 TIRAP CD24 PMC8699546__F3 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation HMGB1 TLR4 MYD88 TIRAP PMC11566483__F2 NLRP3 inflammasome construction and activation NLRP3 PTMS TNF GSDMD PMC11519594__F6 Mechanism diagram of m6A-autophagy-mediated tumor treatment resistance YTHDF2 ULK1 FOXO3A SQSTM1 MTOR DKFZp686F0183 YTHDF1 PINK1 TMA7 METTL3 UBA2 IGF2BP3 DCP2 ARHGAP5 PMC11519594__F7 M6A autophagy axis involved in tumor signaling pathway network METTL14 YTHDF1 IGF2BP3 TP53INP2 HNRNPA2B1 NBR1 PMC6857915__F6 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease ZNRF3 BAMBI INVS APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA NLK SIAH1 PMC6857915__F7 Chronic obstructive pulmonary disease NODAL TPO MSTN TNLG7C TG LEP IL26 IL7 AMH INHA IL2 IL4 IL20 MPL PMC8573870__F11 Effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons SMAD2 IL6 IL4 TNF PEG3 IL1B STAT3 PMC10311769__F2 Revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens MTR MVD MVK IPP PMC7718402__F6 Neutrophil signaling during resolution of inflammation FADD BAX PMC6857915__F8 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease NUMB PMC9530352__F1 Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases IRF7 MYD88 PMC11947922__F1 Novel mechanism targeting Beta-arrestin-2 for the management of diabetic nephropathy ATF4 XBP1 PMC6775696__F11 Interactions between MKI67 and eight genes related to P53 signaling pathway CHEK2 RRM2 CCNB2 CCNB1 CDC2 CHEK1 GTSE1 CASP8 MKI67 PMC6357032__F2 Classification of caspases BCL2 MCL1 BAX PMC8688805__F2 Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review STAT4 EGFR TOB1 CD44 MTOR DDIT4 CCND2 IFNG STAT3 PMC8493876__F1 Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation CD27 DPP4 CD40 LAG3 ICOS PMC9705325__F7 Proposed antitumorigenic mechanism of CPX on GC growth GC CCND1 SRC CDK4 STAT3 PMC8492608__F12 Pathological Features of Tumors of the Nervous System in Hereditary Cancer Predisposition Syndromes: A Review NUMB POLE VHL CD44 SMO PMC6829226__F4 LncRNAs regulate EMT signaling pathways SNAI1 SMAD2 ZEB2 APC GSK3B SNAI2 SMAD4 PMC6033660__F2 Schematics of classical CSR from IgM to IgA BCR HEL-S-11 CA3 PMC7761714__F2 The NRF2 signaling pathway by microRNAs (miRNAs) in cancers MAF KEAP1 GCLC HEL-75 PRXL2A HDAC2 SIRT1 BACH1 PMC9540245__F6 Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis HIF1A HEL-S-133P HK2 HEL-S-68p PMC10625490__F2 HIV infection induces intestinal mucosal barrier damage and immune cell dysfunction, which aggravates the inflammatory response TLR4 TNF IFNG PMC6901542__F6 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NFKB pathway activation through RPS3 VIT LCN2 RPS3 PMC4486656__F2 Fueling Immunity: Insights into Metabolism and Lymphocyte Function FH HEL-S-133P PHGDH GLS PMC11820997__F3 Beneficial effects of hydroxytyrosol (HTyr) on insulin signaling through the enhancement of insulin signaling pathways IL6 TNF IL1B PMC8858030__F3 Mass spectrometry imaging reveals substrate channeling by the purinosome, a liquid-like multi-enzyme assembly PFAS ADSL PAICS PMC5882318__F1 Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway PDK2 MTOR PMC4276889__F6 Reduced HIF-1A expression in TRPM2-S-expressing cells determined by proteomic analysis NPM1 ENO2 TFRC HEL113 HIF1A TFAM HEL-S-133P HSPA4 HEL-S-162eP PMC6568224__F1 Necroptosis signaling pathwayNecroptosis can be caused by a variety of stimuli, including the ligands of the death receptor, TLRs, IFN receptors, and certain pathogens CASP3 RIPK1 TLR4 TRADD CYLD RIPK3 TNF TRAF2 CASP8 TLR3 MLKL PMC8761731__F11 Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer PGR MDM2 TPD52 KLF9 RHO STAT3 PMC3890408__F2 Cooperating mutational events in MYC-driven lymphomagenesis and novel therapeutic opportunities.Notes: Continuous MYC expression is required for BL cell survival, as demonstrated by the apoptotic effect of the MYC inhibitor 10058-F4 on BL cell lines BCR DKFZp781B1423 GSK3B MDM2 PTEN BMF ID3 CDK6 PMC7338604__F1 Wnt/Beta-catenin signaling pathway APC PMC7338604__F2 Natural products targeting the Beta-catenin signaling pathway for cancer therapy PPL RPL10 PMC3653932__F7 TLR4 Activates the Beta-catenin Pathway to Cause Intestinal Neoplasia TLR4 APC AXIN1 CCND1 MYD88 GPR49 PMC8651556__F1 Endothelial Dysfunction and Hyperhomocysteinemia-Linked Cerebral Small Vessel Disease: Underlying Mechanisms and Treatment Timing HEL-S-61p PMC2679751__F7 Proposed model for functional interaction between Ncs-1a, Pi4kB, and Arf1 in trafficking and secretion ARF1 NCS1 PI4KB BMP4 PMC9549509__F6 Therapeutic hypothermia alleviates myocardial ischaemia–reperfusion injury by inhibiting inflammation and fibrosis via the mediation of the SIRT3/NLRP3 signalling pathway NLRP3 IL1B SIRT3 PMC10375321__F1 One-carbon metabolism comprising the transmethylation pathway, nucleotide synthesis pathway, transsulfuration pathway and remethylation pathway HEL-S-61p DHFR MTHFD1 MTHFD2 MTHFS PMC3810143__F9 Downregulation of Nuclear-Encoded Genes of Oxidative Metabolism in Dialyzed Chronic Kidney Disease Patients NRF1 YY1 TFAM PMC11084272__F7 Action of multifunctional FYD in preventing cancer metastasis MMP2 VCAM1 CDH2 TNF PMC5120123__F2 Positive regulatory signaling for Tfh differentiation TBK1 VAV1 CXCR5 ASCL2 KLF2 FOXO1 ICOS ITCH IFNG BCL6 STAT3 PMC5387898__F2 Simplified schematic of the possible mechanism of lymphangiogenesis in cancer cell metastasis VEGFC EMILIN1 SHH PMC4439078__F5 Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes CSRNP1 CEBPE PRRG4 TMEM43 TNFRSF12A MMP19 STK40 UCN TRIB3 CDCA2 MTHFD2 CEBPB FOXP3 CEBPD JDP2 ECT2 KNTC2 ECEL1 SOX11 MKI67 ITGA1 OPRM1 FOS CD34 ATF3 GADD45A CEBPA DDIT3 ISG20 CREM KIF20A APOH TGFB1 HRK PMC7216437__F3 ATM functions in DNA damage repair pathway CHEK2 PALB2 ATM BRCA2 SSB RAD51 ATR H2AX CHEK1 BRCA1 PMC2643928__F1 Activation of the transcription factors IRF3 and NFKB in response to infection with a single-stranded RNA virus TANK TRAF3 IRF3 CASP10 CASP8 FADD MAVS PMC7900405__F6 Schematic illustrating entosis and the actin machinery PCDH7 ARHA RAC1 CDC42 PMC3418847__F6 Interaction Map for PTMScan Direct: Akt/PI3K pathway reagent PIK3R1 BAD GSK3B FOXK1 GOLGA4 PTEN EIF4H MTOR STK24 FYN KHSRP RPS6 GSK3A HRAS PIK3R3 IRS1 FOXO1 RICTOR MINK1 NFKB1 LCK CTNND1 PIK3CA SHB EPHA2 ATR PI4KB PIK3R2 AKT3 PMC3109507__F1 Choosing the right path: does DNA-PK help make the decision? PALB2 BLM BRCA2 BARD1 RAD51 PNKP BRCA1 PMC8134690__F1 HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis BST2 AMBRA1 TRAF6 BCL2 TRIM28 TRIM17 TRIM59 TRIM37 PMC7525032__F6 Scheme of the proposed lung IIR against S CXCL1 TLR4 MYD88 IL1B PMC3162038__F2 Biosynthetic pathway to validamycin A and characterization of VldB, VldE, and VldH MAX PNP PMC7940683__F1 Siglec-G in sepsis TLR4 GSK3B SRC HIF1A STAT3 CD24 PMC7940683__F2 Siglec-G in various immune cells HMGB1 NFATC1 RIGI IRF3 SIGLEC6 CBL TLR4 BCR LYN CD80 MAVS STAT3 CD24 PMC6433784__F1 Mechanism of Action of FSH on Adipocytes UCP1 ATF2 FSHR PMC7387981__F1 Cannabinoids' pharmacology RHO TRPM8 PMC10478283__F8 Mechanism diagram HOXB4 SOX2 CXCR4 MSC POU5F1 PMC6827009__F6 Activation of CREM signaling pathway in spermatozoa of idiopathic infertile patients post-antioxidant treatment hCG_1641087 PRKAR1A CRP PMC4510718__F2 Survivin (SVN) pathways to apoptosis CAD TNF BAX PMC10530547__F3 Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications AFP MMP2 Nbla10317 MMP9 EGFR CCND1 PPARG PMC4361590__F7 Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3B (GSK-3B) and Microtubule-Associated Protein 1B DRAXIN MAP1B GSK3B DCC PMC6396335__F1 Assembly of the interferon (IFN)G receptor (IFNGR) and activation of Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling STAT1 PIAS1 IFNGR2 JAK1 IFNGR1 SOCS1 PMC8103423__F4 Cell biology of Parkinson’s disease NLRP3 PINK1 FYN LRRK2 PLG IL13 LAG3 IL1B CD36 PMC9572491__F1 Mini Review on Molecules Inducing Caspase-Independent Cell Death: A New Route to Cancer Therapy BCL2 BAX PMC3491806__F2 Inflammatory Bowel Disease CCR6 PMC4562633__F3 Discovery of Intermediary Genes between Pathways Using Sparse Regression XCR1 ADORA2B MAPK8 IRAK1 RELB GOLPH3 EIF2B2 MAP2K3 ETF1 OAS3 MTMR12 NOD1 GPR85 RAB11FIP1 ABHD17C GDF15 SMG8 STX11 HEBP1 EME2 ESD CDK5RAP3 RAB8B PSMB9 SERPINB2 PSMB8 AP3B1 FAM111A RAB35 SPOPL PTGS2 NPPC EIF4E TAPBP RAB10 PLEK CCL3 PSME2 PMC4562633__F4 Discovery of Intermediary Genes between Pathways Using Sparse Regression STK40 TIMELESS MNDA NMI B2M NPC2 PSMB9 CASP8 AP3B1 MVP CXCL11 SPPL2A H2AB1 MMP25 RSAD2 ENPP4 LGALS8 SH3GLB1 STARD3 LCN2 GBP7 SHISA5 JARID2 TPST1 PROCR VDAC3 SNRPC GRN GLRX ATP10A RAB10 RAB21 TMEM67 SLC25A22 TMCO3 PARP12 PARP11 MITD1 TNP2 CASP4 IFIT2 VASP MOV10 NOD2 ISG15 SP110 TAP2 NOD1 LGALS3BP RAB32 RAB35 CFB RRBP1 PPP2R5A CHMP4B TAPBP MAPK6 PSME2 PMC11747344__F6 Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation BAD FAR1 BRAF POLK TPR CDC37 PTEN RAC1 MTOR IRS1 RHEB TSC2 RET BCR TFG MDM2 CCND1 SYK RBL2 CD19 BAX PMC3118418__F1 Which FGF ligands are involved in lens induction? FOXE3 SIX3 BMP7 OTX2 PROX1 BMP4 PMC4930925__F4 Gene circuits for biomedical applications HRH2 IL22 CREB1 LSR TNF STAT3 PMC4750973__F5 Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle RPL31 ELF3 RPS2 RPL35 REST RPL10A RPLP1 RPL7 ELL PMC9181451__F3 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases DCAF15 RBM23 PMC9181451__F4 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases CDK12 RBX1 DDB1 PMC5142754__F1 Targeting Inflammation in Cancer Prevention and Therapy IGF1 CCL2 STAT3 PMC5142754__F2 Targeting Inflammation in Cancer Prevention and Therapy HEL-S-62p TLR4 IRF3 PMC9181451__F1 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases IKZF1 DDB1 CRBN PMC12025505__F2 Signaling Mechanism of Budding, Proliferation, and Tissue Regeneration in Cnidaria APC LATS1 LATS2 PMC8579452__F3 IL-1B in atherosclerotic vascular calcification: From bench to bedside NLRP3 LRP5 LDLR LRP6 RAC1 IL1B PMC8035348__F3 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma MUC13 RREB1 APC GSK3B PTEN EZH2 SOCS1 PMC8035348__F4 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma TH OS9 HOXA9 LDLRAD3 PTN ARHA EZH2 PMC5799771__F7 CK1Alpha-, 26 S proteasome-dependent turnover of FOXO tumour suppressors in RAS-mutant cancer cells FOXO4 NRF1 MTOR PMC7755484__F7 Proposed mechanism of AS-IV-induced melanogenesis AHR TYRP1 PMC3500781__F1 Two different pathways could bypass DNA damage causing stalled replication forks REV1 RAD18 PCNA PMC7288008__F3 Pathophysiology of Ulcerative Colitis CXCL1 CXCL10 CXCL8 CXCL3 IRF4 GATA3 FOXP3 PMC9315664__F4 Advances in Crosstalk between Porcine Circoviruses and Host CGAS SOCS3 STAT2 IRF7 DNAJC7 IRF3 CGA MYD88 SIGIRR EIF2A KPNA3 SP1 TRAF2 IL1B MAVS STAT3 PMC4445694__F1 Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists’ arsenal SP1 STAT3 PMC7723564__F7 Primary mechanism of PRP improves chronic inflammatory pain HMGB1 GFAP STAT3 PMC6616296__F10 Proposed mechanism of the p75NTR as a mediator of synaptic changes during SD ROCK2 ARHA BDNF PMC4219936__F2 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice DKFZp666G145 S1PR2 TLR4 FGF19 SPHK1 SPHK2 IL1B CYP7A1 PMC4537170__F1 Mammalian base excision repair and single-strand break repair pathways FEN1 POLE LIG1 PNKP PCNA MPG NEIL1 PMC4219936__F1 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice CYP8B1 CYP7A1 PMC10418722__F12 Study on the Regulation Mechanism of Quality Deterioration Due to Chilling Stress and Dry Exposure during Anhydrous Storage and Transportation of Yesso Scallop Patinopecten yessoensis OMP APP JUN PMC5780146__F5 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the TNF signaling pathway CASP3 CA13 TRAF3 IL6 TNF TRAF2 FADD NOD2 CST2 MLKL SELE ITCH PMC5780146__F6 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the influenza A pathway ADAR PML SOCS3 IRF9 CUTA CASP9 IRF3 IL6 IFNG PMC8913936__F3 Proteomic Analysis Reveals a Novel Therapeutic Strategy Using Fludarabine for Steroid-Resistant Asthma Exacerbation STAT1 IFIT3 CANX TAP2 STAT2 TYK2 JAK1 TNF B2M TAPBP PMC4461786__F4 Noncanonical Wnt5a signalling: a simplified view RYK ROR2 PMC3611005__F10 LKB1-SIK2/3-class IIa HDAC pathway as a novel signaling module SIK2 HDAC7 SIK3 CRTC2 HDAC5 PMC7864190__F2 Latent TGFB activation and the canonical TGFB signaling pathway SMAD2 PMC8814522__F4 Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis MYB ARG2 HBS1L ARG1 KLF1 PMC8167679__F1 Iron homeostasis and iron-mediated ROS in cancer SLC7A11 CDC2 STAT3 PMC8097341__F2 Various mechanisms underlying targeting of de novo DNMTs by histone methylation NSD2 SETD2 DNMT3B DNMT3L PMC4632302__F9 Diagram of signaling pathway for genistein-induced apoptosis in Bax and p53-independent manner CASP3 APAF1 CASP9 PMC8841732__F10 All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐KB Signaling Pathway TRAF6 IL1B MAVS PMC10980521__F7 Main pathways of reproductive candidate genes for follicular growth and ovulation in Tibetan sheep IGF1R SMAD4 CYP11A1 RGMB BMP4 BMPR2 IGF1 IGFBP2 GNAS LHCGR DIPLA1 SMAD1 STAR DKFZp781O1323 PMC7993417__F4 Phenotypic diversity and metabolic specialization of renal endothelial cells LAT SIRT3 PMC7993417__F5 Phenotypic diversity and metabolic specialization of renal endothelial cells KLF4 NOX4 KLF2 LPA LPAR1 HAS2 TFAM SIRT1 PMC3769322__F3 Regulation of action cytoskeleton in LTLT-Ca MCF-7 cells CD14 VASP FYN GNA13 RHO HEL114 CRK PMC12179639__F1 Scientific diagram illustrating the mechanism of FGFR1 signaling, showing key pathways like PI3K-Akt-mTOR and RAS-RAF-MEK-MAPK for cell survival and proliferation FGFR1 FOS PTEN MTOR JUN PMC1855985__F1 Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 BRAF MAP2K4 EGFR MAPK7 ERBB3 MAPK3 FGFR3 FGFR4 HRAS FGFR2 RPS6KB1 MAPK12 MAPK13 ERBB4 MAPK6 RPS6KB2 MAPK11 ARAF PMC6362409__F1 Microbiota and the intestinal barrier against infectious threats TH TLR5 TLR4 IL6 IFNG PMC12179639__F2 Interactions between the PD-1/programmed death-ligand 1 (PD-L1), fibroblast growth factor receptor 1 (FGFR1) pathways, and chemokines FGFR1 CX3CL1 CXCL10 FGF2 NEDD4 IFNG PMC9581278__F9 Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARAlpha-SREBPs pathway CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 TG NR1C1 CYP7A1 PMC8517756__F2 Endothelial dysfunction and COVID-19 (Review) TNF ACE2 PMC6551999__F5 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? CYC1 CCND1 STAT3 PMC7343815__F4 Autophagy as a modulator of cell death machinery DKFZp686F0183 PMC6551999__F1 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? DAO PMC2821201__F6 A diagrammatic model to summarize the role and subcellular localization of survivin and its splice variants in the regulation of apoptosis and control of mitosis in cancer cells CDC20 INCENP PMC10559578__F2 Production of IL-1B and its transduction signaling pathway NLRP3 IRAK1 TRAF6 TXNIP IRAK4 MYD88 GSDMD PMC3491906__F1 Distinct signaling pathways of synaptic and extrasynaptic NMDAR in neuron fate SIK2 ATF3 TXNIP BDNF PMC11846447__F4 Muscle protein regulation through the mTOR pathway TSC2 IGF1 RPS6 MTOR IRS1 PMC12191313__F3 Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression APC TNF PMC3528293__F1 Generalized overview of the extrinsic and intrinsic apoptosis pathways TRADD TNF FADD BAX PMC11171594__F1 TLR-mediated signaling HMGB1 TLR5 TLR9 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 TIRAP PMC6705839__F3 System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells E2F4 PLK1 SMAD2 GSK3B SMAD4 DBF4 ORC3 CDK7 CDC45 ORC2 CDC20 SMC3 CDK2 MDM2 CDC2 RAD21 PCNA SKP2 MYT1 PMC8671568__F1 Neuroadaptations and TGFB Signaling: Emerging role in models of neuropsychiatric disorders CAP2 DBN1 RUNX2 ACVR2A TGFBR1 ARHA TMEPAI SMURF1 SMAD1 DKFZp781O1323 BMP4 MEF2D PMC7495088__F9 PIgR regulation in CF lung IL17A PIGR CFTR PMC3865699__F1 Major mechanisms linking obesity with impaired muscle regeneration MTOR IL1B PCNA PMC4841026__F5 Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study GPX4 ADAM9 PAK6 NR3C1 DDB2 CREB3 TFPI2 SLC52A1 EDNRB ARD1A FBRS CFH KHSRP TNFSF14 JUN PMC3500394__F1 FoxM1 and WntBeta-catenin Signaling in Glioma Stem Cells FOXM1 APC LRP5 CCND1 LRP6 TCF4 PMC5794818__F2 T cell activation induces autocrine and intracellular complement activation that regulates T cell metabolic function and inflammasome formation CTSL HEL-S-62p NLRP3 CD46 MTOR ELL FOXP3 PMC8075059__F3 Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis EDAR TNLG7C PMC8424978__F7 Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway SELP SELE STAT3 PMC5856858__F1 KEGG Apoptosis pathway with highlighted dysregulated mRNAs and miRNAs ME1 BAD AIP SET TRADD PIR CASP2 HTRA2 ATF4 CSA2 MCL1 CAD TRAF2 FADD HRK PMC4727405__F8 Alternative NOTCH pathway representations PRKCA NUMB NPM1 PAWR DLL4 LATS2 NCOR2 PMC5541362__F2 Serotonin and serotonin transporters in the adrenal medulla: a potential hub for modulation of the sympathetic stress response TH SET PMC4727405__F4 Screenshot of CNV and splicing representation BAD MTOR PMC5797067__F1 Exon 3 mutations of CTNNB1 drive tumorigenesis: a review APC GSK3B TEF AXIN1 AXIN2 PMC6754810__F1 Activators and suppressors of OCT4 in cancer stem cells FOXC1 VEGFC APC SENP1 PMC9310348__F1 Apoptosis regulation through protein–protein interactions BAD APAF1 BIK BMF FADD HRK BAX BOK PMC6830904__F1 Intracellular NAD metabolism AOX1 NAMPT NMNAT1 NMNAT2 NNMT NMNAT3 NRK PMC10915323__F1 Leveraging molecular targeted drugs and immune checkpoint inhibitors treat advanced thyroid carcinoma to achieve thyroid carcinoma redifferentiation EGF RET HGF EGFR GDNF TPO FLT3 MTOR PMC7750537__F6 Crosstalk between the coagulation cascade and autophagy on tumor-associated endothelial cells ATG14 FOXO1 PMC7750537__F7 Crosstalk between coagulation and autophagy promotes cancer-associated thrombosis and metastasis TGFA PMC3688827__F6 Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection EGR1 PLAUR GCLC MYC HMOX1 NLRP3 AHR CDKN1A NFKB1 DNAJB6 ABCC1 SRC DNAJB2 THBS1 ITGAV KPNA3 JUNB REL TGFB1 IL1B PMC7750537__F1 Coagulation and clotting factor signaling TFPI PLG APC PMC8350333__F8 Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization INSM1 MEN1 CCND1 HES1 PMC7750537__F2 Autophagic pathway ATG12 ATG3 VWF BCL2 ATG101 ATG10 ATG14 DKFZp686F0183 PMC7750537__F5 Crosstalk of the coagulation cascade and autophagy pathway in cancer cells ATG12 IL1B TF PMC7567008__F3 Crosstalk between Toll-like-receptor (TLR) signaling and the Hippo pathway in Drosophila and mammalian cells TBK1 TRAF3 TRAF6 IRF3 IRAK4 ECSIT MYD88 PMC4338943__F1 Retinoid signaling (RA) signaling pathway DHRS9 CRABP2 HEL-S-53e HEL-S-4 CYP26A1 LRAT CYP26B1 CYP26C1 ALDH1A3 CRABP1 RBP4 DHRS4 RDH10 ALDH1A2 ALDH8A1 PMC8076900__F1 Control of T Cell Metabolism by Cytokines and Hormones SLC7A5 IL21R IL7R MTOR PMC5056151__F2 Transport proteins in Alzheimer’s disease ABCC1 ABCG2 ABCA1 ABCB1 APOE PMC10216079__F3 Main signaling pathway in rheumatoid arthritis APC TNF MTOR PMC5666796__F9 Schematic model of possible signalling events involved in the upregulation of TGFB1 expression by LTBP-2 F2 F3 LTBP2 PMC4253516__F7 Transforming growth factorB (TGFB) and the canonical Smad pathway negatively regulate CD1d-mediated antigen presentation SMAD2 SMAD4 PMC6130320__F4 MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics CD44 CD74 PMC3830618__F2 Homeostatic plasticity at the Drosophila neuromuscular junction SNAP25 CDC42 PMC12010972__F4 Targeted therapy for osteoporosis SOST LRP5 LRP6 WIF1 PMC12010972__F2 Inhibition of Wnt/Beta-catenin signaling pathway by Wnt signaling pathway inhibitors RUNX2 SOST LRP5 DKK1 WIF1 PMC12010972__F3 Wnt signaling pathway inhibitors RUNX2 APC SOST GSK3B LRP5 LRP6 DKK1 WIF1 PMC12010972__F1 Regulatory mechanisms of the Wnt signaling pathway RUNX2 APC LRP5 LRP6 ARHA ROR2 JUN PMC7567008__F1 Tumor-cell-intrinsic roles of Yap/Taz in regulating tumor immunity LATS1 LATS2 PMC7471657__F3 Gene ontology terms and KEGG pathways PTPRC KRT20 SNCA CD3D MS4A1 IL6 CD8A CD3G CD68 PDCD1 CD3E FOXP3 PMC9751411__F2 Interferon and interferon-stimulated genes in HBV treatment STAT1 STAT2 IRF9 IFNAR2 IFNAR1 PMC5591558__F3 EGFR cell signaling and lncRNAs relationship in lung cancer therapy resistance IGF1R EGFR GRB2 PTEN MTOR IRS1 PMC4649479__F1 Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei PC PMC8835863__F1 Apoptosis during ZIKA Virus Infection: Too Soon or Too Late? ATF4 XBP1 FADD PMC5698512__F1 IL-6 signaling pathways CCND1 MTOR ADAM17 PMC9453844__F6 Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose RSPO3 PRICKLE3 FOSL1 WNT16 NR1C2 WNT2B WNT10B STAR PMC11594159__F1 Redrawn from WSP268, the version of the Notch signaling pathway depicted on Wikipedia https://www CTBP2 NUMB MAML3 CTBP1 JAG2 LFNG MFNG DLL3 NOTCH3 HES1 HES5 DTX3L DLL4 NOTCH1 DVL2 HDAC2 NCOR2 NOTCH2 MAML1 NOTCH4 PSEN2 DTX1 DTX2 DTX3 DTX4 TNF HDAC1 DVL3 DVL1 CREBBP APH1B PMC122866__F4 The pathway of PUFA synthesis in C FAT2 FAT1 FAT3 FAT4 PMC6770240__F1 Overview of an acute myeloid leukemia cell’s metabolism HEL-S-26 GLS PMC7552539__F5 Simplified examples of the roles that different classes of ceRNAs play in HCC oncogenesis ASAP1 ARHA USP22 SIRT1 PMC2905036__F3 Schematic diagram depicting the molecular mechanisms by which inflammation activates hepcidin transcription in the liver BMP6 SMAD4 IL6 SMAD1 DKFZp781O1323 STAT3 PMC2905036__F2 Schematic diagram depicting the proposed role of bone morphogenetic protein (BMP) signaling pathway, HJV, HFE, and TFR2 in iron sensing and hepcidin regulation in the liver BMP6 SMAD4 TMPRSS6 HFE SMAD1 DKFZp781O1323 TFR2 PMC8532063__F1 Current Diagnosis and Management of Primary Chylomicronemia LPL LMF1 GPIHBP1 PMC11641621__F3 Schematics describing the role of particular small-molecule protein kinases and their inhibitors in PAH microenvironment, including such molecular hallmarks as inflammation, apoptosis, proliferation, or mitochondrial function ALK EGFR FLT3 MTOR DDR2 PMC3334602__F7 Cordycepin analogues and the C ADA NT5E PNP ADK PMC5036407__F6 Illustration showing the mechanism by which NDRG1 mediates activation of the Wnt signaling pathway APC TLE2 PMC5609400__F3 The Shh, TGFB/BMP, and Wnt morphogenic signaling pathways DAAM1 SUFU APC PTCH1 GSK3B LRP5 SHH LRP6 SMO RHO PMC5029616__F1 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters MMP2 MMP9 GSK3B ARHA PMC5029616__F2 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters MDM2 SP1 TFAM PMC3168677__F2 MicroRNAs in Rheumatoid Arthritis TLR4 IRAK1 TRAF6 IRAK4 IL6 MYD88 IL1B PMC9393262__F1 Th2A cells: The pathogenic players in allergic diseases COX1 APC IL33 ZAP70 TRAF6 MYD88 PMC9698307__F1 Emerging Direct Targeting Beta-Catenin Agents APC LRP5 LRP6 BCL9 PMC5773404__F2 Synaptically Localized Transcriptional Regulators in Memory Formation ARC NPAS4 BDNF CRTC1 PMC6895530__F6 Working model BCL2 MTOR BAX PMC8696218__F8 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells SNAI1 TWIST1 SMAD2 TGFBR1 TGFBR2 SMAD4 PMC8696218__F6 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells APOA5 CPT2 PMC8696218__F7 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells IGF1R SOX2 ERBB2 EGFR MYC MTOR PMC8696218__F4 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells BMP2 MMP9 MYC RELB CCND1 CCL19 TNF LTBR TERT PMC4617547__F1 Summary of unfolded protein response and endoplasmic reticulum stress signaling pathways ATF4 ATF2 EIF2A EIF2AK1 TRAF2 PPP1R15B XBP1 JUN PPP1R15A STAT3 PMC8696218__F5 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells MMP2 MYC STAT3 PMC2779759__F7 Schematic model illustrating how Jun proteins regulate the TIMP-3, TACE, and TNFA pathway: Jun proteins transcriptionally activate TIMP-3 expression, which is responsible for TACE inhibition TIMP3 JUNB TNF PMC8696218__F2 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells DLL4 JAG2 MYC FURIN DLL3 SOX9 PMC8696218__F3 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells SNAI1 CCNB1 MYC SMO PMC2528859__F2 The UPR sensors PERK, IRE1A, and ATF6 control mRNA translation and transcriptional induction of UPR-regulated genes ATF4 EIF2A IAPP PMC8696218__F1 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells TNIK APC GSK3B MYC AXIN1 GPR49 PMC9495000__F6 Transcriptome Analyses Provide Insights into the Auditory Function in Trachemys scripta elegans GABBR2 KCNJ6 SLC38A1 GABRR3 PMC9520664__F1 V-Set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy HEL-S-62p NLRP3 VSIG4 PDK2 PMC8564058__F9 An ATX-LPA6-GA13-ROCK axis shapes and maintains caudal vein plexus in zebrafish ARHA LPA PMC3310050__F12 Folate Decorated Dual Drug Loaded Nanoparticle: Role of Curcumin in Enhancing Therapeutic Potential of Nutlin-3a by Reversing Multidrug Resistance MDM2 BCL2 BAX PMC7249327__F6 At the top of the signalling pathway, the critical Arpp19 dephosphorylation at S109 by PP2A-B55D MOS ARPP19 CDC2 PMC5929433__F1 Ceramide species are elevated in human breast cancer and are associated with less aggressiveness SMPD2 ORMDL1 GBA2 ASAH2 SMPD4 ORMDL2 ORMDL3 SGMS1 UGCG SGPL1 SMPD1 CERK SGMS2 PMC4162460__F8 Schematic for reprogramming of EBV-induced glucose metabolism GSK3B MYC HK2 PMC6441621__F1 miR-223 regulates the canonical NFKB pathway and other pathways related to cancer IGF1R MAFB NFAT5 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 FOXO1 STAT1 NLRP3 PKNOX1 REL MEF2C STAT3 PMC8760138__F3 Chloroplast ROS and stress signaling FECH PMC2940478__F3 Web-accessible GnRHR pathway navigator CDA REST PMC8698532__F2 Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic Molecules NLRP3 TLR4 SPRY1 PMC11995514__F5 Core mechanism of necroptosis and related kinases affect the signaling pathway RIPK1 TRADD RIPK3 TRAF2 FADD ZBP1 MLKL PMC9326668__F1 Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease ATP13A3 SMOX SRM PAOX SLC3A2 SLC22A3 ARG1 SLC22A2 SMS SLC22A1 SLC12A8 PMC11995514__F6 Core mechanism of ferroptosis and related kinases affect the signaling pathway GPX4 AIFM2 SLC7A11 SRC FGFR4 SLC40A1 DDR2 TCF4 SIRT3 PMC11995514__F3 Core mechanism of pyrotosis and related kinases affect the signaling pathway NLRP3 TRADD NLRP1 EGFR GZMA GSDMC GSDMB GSDMD STAT3 DFNA5 PMC11995514__F4 Core mechanism of autophagy and related kinases affect the signaling pathway ULK1 PLK1 ATG12 ATG3 PIM2 EGFR BMX SYK ATG101 ATG10 DKFZp686F0183 STAT3 PMC3519956__F6 Schematic model depicting how HMW isoforms regulate bone formation FGF23 FGFR1 FGF2 PMC11995514__F2 Core mechanism of apoptosis and related kinases affect the signaling pathway EGFR MTOR STAT3 BAX PMC5313453__F2 Figure illustrating five pathways putatively causing pathological remodelling in ACM: 1) Deficits in EB-1 ID protein trafficking provoke disturbance of the ID morphology PLN GSK3B PMC3928173__F4 Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis PIWIL2 PIWIL1 PIWIL4 TDRD1 PMC4889278__F6 Upon tumor progression E-cadherin downregulation leads to an increase of the proportion of CSCs and acquisition of the ability to form secondary foci of tumor growth SOX2 PMC2729687__F2 Immunological synapse or the interface between an antigen presenting cell and a T-cell APC CTLA4 PTPN22 FOXP3 PMC9563579__F1 Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation IRF3 TNF PMC3185522__F3 HCV induces the over-expression of PP2Ac via an ER stress response pathway STAT1 PRMT1 TYK2 IFNAR2 JAK1 PMC3865984__F1 Autophagy Pathway ATG12 ATG3 ATG10 DKFZp686F0183 PMC3865984__F2 Molecular regulation of autophagy ULK1 ATG101 MTOR RB1CC1 PMC9127500__F9 Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway CDK2 ATF4 MTOR PMC11789495__F5 MTORC1 signaling pathway extensively controls cellular metabolism ULK1 PFAS PGM2 FOXK1 ENO1 HEL-S-87p HIF1A MTHFD2 PHGDH HEL-S-68p HEL-S-49 TFEB PSAT1 ATF4 PSPH SRPK2 HEL-S-70p HEL-S-51e CAD HK2 MTHFD1L PMC5291092__F8 Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox KEAP1 GCLC ALB NQO1 PMC7364497__F2 Crosstalk between key signal pathways during prostatic budding NKX3-1 PMC7272660__F5 Genes mapped to KEGG pathways by pathway analysis MPL EMP1 PMC4284387__F2 MiR-124 and miR-9/9* engage in complex regulatory circuits activating a neuronal gene expression program PTBP1 REST HES1 PMC11617408__F6 Activin and BMP signaling pathway SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC4107712__F1 Illustration of the PI3K/Akt/mTOR pathway TSC2 TSC1 EGFR PTEN DEPTOR RHEB PMC11617408__F5 Apoptosis: Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) initiates cell death through two mechanisms: direct caspase activation or indirect activation via the release of apoptogenic factors from mitochondria TRADD TNF TRAF2 FADD PMC6073766__F1 Major downstream signaling pathway of mTORC1 and mTORC2 ULK1 TFEB DEPTOR MTHFD2 PMC7317437__F5 Proposed schematic diagram of signalling pathways for doxorubicin‐induced muscle atrophy IGF1 SMAD2 MSTN BNIP3 MTOR IRS1 PMC2701885__F2 Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence TBK1 SOCS3 IRF7 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 TLR3 SOCS1 PMC11214400__F6 Inflammatory loop involving Staphylococcus aureus, IL-36G, and cathepsin S drives immunity disorders in familial acne inversa keratinocytes KLF4 IFNG PMC11549404__F9 Molecular mechanisms underlying FNDC4-mediated protection against cardiac I/R injury FNDC4 HIF1A PMC7393197__F3 Antitumour peptide based on a protein derived from the horseshoe crab: CIGB‐552 a promising candidate for cancer therapy CASP3 RAB5A CASP9 HEL-S-44 COMMD1 CASP8 BAX PMC2861543__F6 Differential role for endocytosis in receptor-dependent Nox1 generation of ROS and activation of cellular signalling EGFR ATF1 PMC7649120__F6 Scheme of possible pathways by which liposomes can “hit” PIM cells via C activation; example for the case of PEGylated liposomal doxorubicin (Doxil) and other PEGylated NPs HEL-S-62p CR2 ATR CR1 CP PMC4583851__F5 The differentially expressed profiles TRADD TRAF3 LTB TRAF6 NLK COX2 LTA MAX BCR BASH LBP SYK ECSIT TRAF2 LAT PMC8256842__F8 13-Gene Metabolic Prognostic Signature Is Associated With Clinical and Immune Features in Stomach Adenocarcinoma LIF INS SHE CGA PMC8473087__F5 COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NFKB Pathway IL10 TLR8 TLR7 TLR4 IRF7 VCAM1 IL13 CXCL10 IL4 ACE2 TLR3 TMPRSS2 PMC3588179__F2 T-cell immune regulation by IDO1 PDC HEL-S-92n CD19 PMC6831453__F1 Multiple immunosuppressive mechanisms coexist in tumor microenvironment HMGB1 CCR5 CXCL1 CXCR1 CCR2 TLR9 VEGFA CCL2 MTOR TLR3 TDO2 TLR8 COX2 TLR7 TLR4 AHR CXCR4 CD80 CXCL12 ARG1 PMC3588179__F4 The mechanism of IDO1 regulation on viral infectious diseases IDO1 PDC MTOR PMC4673281__F6 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic ROCK2 BAMBI NODAL PITX2 APC SOST CER1 SMAD4 SKP1 ARHA RBX1 LTBP1 IFNG FST NLK LEP THBS1 PMC11518755__F1 Molecular alterations of RAI-RTCs RET BRAF ALK ARID2 PTEN MTOR PAX8 PMC8070110__F2 Schematic diagram of the interconnection between EMT and TRF1/2 MMP2 TWIST1 SMAD2 MDM2 SMAD4 CDH2 TERT PMC11518755__F2 NIS expression TSHR SMAD2 SMAD4 TTF1 PAX8 PMC4516463__F1 Signalling pathways involved in skeletal muscle remodelling and atrophy following disuse IGF1 SMAD2 MTOR IRS1 BAX PMC8848474__F1 Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells TSC2 FOXO3A PTEN PMC3811055__F2 mTOR pathway APC IL2 CD80 MTOR PMC3594971__F3 c-jun N-terminal kinase (JNK) pathway in postmitotic migrating neurons MAP1B RAC1 PMC11989508__F3 In PD, the molecular mechanism of ERS involves the interaction of multiple factors LRRK2 EIF2A THBS1 FAM171A2 PMC11989508__F4 In PD, ERS forms a complex vicious cycle with mitochondrial dysfunction, oxidative stress, and neuroinflammation, collectively driving disease progression HMGB1 TLR4 LRRK2 BAX PMC11989508__F1 ER is a membranous network structure in eukaryotic cells, divided into the RER and the SER ATF4 EIF2A PMC4042834__F4 An example of a KEGG pathway containing genes involved in multiple processes EGF BRAF NGF ATF2 EGFR RASA2 NRAS MYC TRAF6 PPM1B NF1 TNFSF6 MAP4K3 ATF4 ECSIT JUN CD14 MAP3K1 MOS CHP2 FOS TNF MAP3K7IP1 HEL-S-31 DDIT3 NLK CASP3 HEL-S-102 MAX RELA EVI1 GRB2 RAF1 TRAF2 MEF2C CDC42 PMC3847167__F4 Lines/LINS plays a putative dual role in WNT canonical pathway WNT1 PMC4648177__F3 IG20pa and MADD as antagonists in the TRAIL-induced apoptotic pathway MADD FADD PMC7020748__F2 Key pathways most frequently mutated in MPM all contribute to global downregulation of microRNA levels NF2 MYC MDM2 DROSHA BCL2 EZH2 LATS2 BAP1 PMC5500790__F1 Wnt signaling pathways APC RYK RHO PMC6069411__F1 Canonical Hh signaling pathway SUFU GSK3B SMO PMC17314__F1 An integrated view of the biology of Halobacterium NRC-1 SRP54 SRI CD2 SRP19 PMC6069411__F2 Canonical Wnt/Beta-catenin signaling pathway [,,,,,,,] MMP7 IGF2BP1 SOX2 APC GSK3B CD44 BCL9 MAL PMC11434717__F3 Terpene trilactone biosynthetic pathway MVD MVK IPP PMC7818012__F2 Mass spectrometry-based protein‒protein interaction techniques and their applications in studies of DNA damage repair POLD4 POLD2 PALB2 CETN2 RPA3 CHAF1B CHAF1A HMCES UIMC1 USP28 NBN NUDT16L1 PRIM2 ABRAXAS1 PRIM1 RBBP8 TP53BP1 PMS1 XRCC5 MLH3 POLE2 POLE4 POLE POLA1 POLA2 APEX1 POLE3 MSH6 RPA4 RAD50 ERCC5 RAD52 RAD51 MSH3 MSH2 H2AX MSH4 MSH5 HEL-S-71 BRIP1 MDC1 UBE2H XPC BARD1 DDB2 NEDD8 LIG1 RBX1 DDB1 MRE11A BRCA1 UVSSA XAB2 BRCA2 ERCC1 ERCC2 DNA2 PCNA BLM CCNH POLG TOP2A WRN CDK7 MNAT1 ATM POLR2A HMGN1 POLK RPA1 PARP1 BRCC3 POLD3 RFC3 RFC4 PMS2 RFC1 RFC2 EP300 OGG1 PNKP PMC8962344__F2 Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery EPO AK3 VHL BCL2 CAD HEL-S-133P HEL-S-68p PMC8221351__F9 Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/Beta-catenin pathway BACE1 WNT3A PMC7527296__F1 IL-6-STAT3 signaling is a potential therapeutic target for COVID-19 mediated by cytokine storm EGFR HBEGF ACE2 ADAM17 TMPRSS2 STAT3 PMC8134730__F7 Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice LIMK1 RAC1 MTOR BDNF PMC6539991__F4 Gene-Pathway network CDC20 BAD FYN VEGFA BCL2 PCNA PMC6539991__F5 Sub-molecular network of CC, EC and VC CCNA2 IGF1 FGF2 VEGFA BCL2 CDC2 PMC6539991__F3 Pathway networks MIA RAN PAH PMC5952219__F2 TLR4 signaling pathway TBK1 HMGB1 RIPK1 IRF7 IRAK1 IRAK2 TRAF6 IRF3 MYD88 TNLG7C MAL PMC2776748__F1 A, Schematic diagram showing intra-cellular functions of the Bcl family of proteins BAD APAF1 CXCL8 TNF BAX PMC10138871__F7 NpPP2-B10, an F-Box-Nictaba Gene, Promotes Plant Growth and Resistance to Black Shank Disease Incited by Phytophthora nicotianae in Nicotiana tabacum SKP1 PMC11203709__F3 VHL-mediated signaling/regulatory pathways in ccRCC with respect to PAX involvement PAX2 SMAD2 SMURF2 APC GSK3B MYC VHL CCND1 SEMA6A MTOR PAX8 PMC4110518__F1 Cellular origin of thyroid carcinomas is shown BRAF PAX8 PMC8536509__F2 MTORC1 by amino acids in mammalian cells: A general picture of recent advances RICTOR ULK1 TFEB IGF1 PRR5 MTOR DEPTOR IRS1 RHEB MLST8 PMC9495330__F13 Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity TLR4 TRAF6 MYD88 PMC7817106__F7 Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation SOX2 ADA HDAC2 SOX10 PMC4562270__F4 Proteomic approaches for profiling negative fertility markers in inferior boar spermatozoa GPX4 MAPK8 MAPK3 ACTN1 GSK3B INS MYC HSPD1 IFNG UQCRC1 APP MAPK1 GYPC ACRBP GSTM3 SP1 EMB RAB2A IL1B SDHA ACR BAX STAT2 PTGS2 BST2 CEBPA IL6 TNF AVPR2 PS1TP5BP1 HEL-S-162eP CASP3 VCAM1 RELA AVP BCL2 TUBA1B TGFB1 CYCS STAT3 PMC11666154__F5 LTBP3 combined with SLC (TGFB and LAP via disulfide bonds) significantly strengthen the bioavailability of TGFB RBP1 SMAD2 SMAD4 pp6425 PMC7559172__F7 Wnt signaling pathway enriched in KEGG ROCK2 BAMBI INVS STOM APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA NLK DAAM1 SIAH1 PMC2131730__F4 LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell) CD14 TLR4 LBP MYD88 TIRAP PMC3278537__F2 Signaling Pathways Underlying the Pathophysiology and Treatment of Depression: Novel Mechanisms for Rapid-Acting Agents GRB2 PTEN BDNF PMC9678415__F7 Systematic review of the biological mediators of fat taste and smell SRC CALHM1 TRPM5 STIM1 PMC6598280__F2 Paracrine effects of the ASC secretome and involved pathways PDGFD IGF1 CRP IL2 PMC9030409__F4 Personalized Diagnosis in Differentiated Thyroid Cancers by Molecular and Functional Imaging Biomarkers: Present and Future BRAF PDGFRA ERBB2 NOX4 MTOR BRD4 SLC5A5 PMC3654375__F2A Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning FYN CDK5 ARHA RAC1 PMC12041035__F3 Exosomes mediate crosstalk between kidney cells TEC TNF HK2 PMC8798716__F9 Identifying the potential regulators of neutrophils recruitment in hepatocellular carcinoma using bioinformatics method ADA RHO CAD OTP LAT PMC12041035__F5 Exosomes mediate cell regeneration, repair, and fibrosis SOCS1 HK2 PMC7196612__F2 Virulence factors of Fusobacterium (F.) nucleatum ULK1 TIGIT MYD88 PMC7196612__F3 Oncogenic properties of Bacteroides (B.) fragilis STAT3 PMC4269881__F6 EHEC-host interactome reveals novel targets for the translocated intimin receptor IKBKG TUBA4A TRADD IRAK1 TRAF6 IRAK4 MYD88 UBC TLR4 UBE3A CD14 METTL21A NCALD SLC34A1 TUBB HPCAL1 RBCK1 DTX2 BAIAP2 ARHA MAP3K7IP1 HEL-S-162eP TRAF5 TRAF2 CDC42 PNP PMC7232345__F7 Proposed model for OAS2 regulation of ZIKV replication and IFN pathway STAT1 IFIT2 OAS2 STAT2 IRF7 IRF9 IRF3 PMC12041035__F1 Biogenesis, secretion, and structure of exosomes CD9 CD63 CD82 CD81 PMC4123081__F1 Simplified schematic representation of the extrinsic and the intrinsic (mitochondrial) pathways of apoptosis and necroptosis TRADD TRAF2 FADD BAX PMC4133905__F2 Normal, physiological insulin signaling transduction (left) and an altered pathway following insulin withdrawal (right) in adult hippocampal neural stem cells TSC2 TSC1 MTOR PMC4123081__F4 Ingenuity Pathway Analysis of the miRNAs identified as involved in regulation of cardiomyocyte apoptosis (see ) INPP4B IFNG ANGPTL1 TINAG DOCK6 SPRR3 UXS1 TMPRSS4 AFM FUT6 FOXO6 PROKR1 FAM168A DUOXA2 TK1 PLAC1 SLC16A9 IP6K3 OSBPL7 BTN1A1 SEMA6D IGF1 INSRR TRPV2 CLEC4A RAB36 SCGB3A1 SIRT1 PMC11211753__F6 Possible mechanisms of action of TR for altering ECM turnover PLG SMAD2 SMAD4 PMC8430761__F1 Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends? IRS4 SOCS3 PTEN MTOR INSR POMC NPY AgRP KISS1 GRB2 CARTPT SH2B1 CRTC1 STAT3 PMC6925433__F4 The insulin signal pathway TSC2 BAD GRB2 INS EIF4E MTOR RHEB INSR CBL PMC8062261__F12 TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NFKB activation IRAK1 SHARPIN TRAF6 IRAK4 MYD88 COIL PMC3271076__F8 Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network POLA1 PAX7 YY1 ARHA HAND2 CDC42 CCND2 PMC3654375__F1A Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning SEMA4D ERBB2 RRAS ARHA RAC1 RND1 PMC7605384__F6 Network of the tRF-mRNA-pathway constructed with 7 selected tRFs (5 were upregulated and, 2 were downregulated) and their target gene PRKCZ FZD3 PPP3CA PORCN FLNB TAOK1 PRKCA VAV3 FGFR1 XCL1 ADCY1 CXCR5 CACNA2D4 PRKACG PLCB1 CACNG8 DAAM1 PAK1 RASGRF1 STK4 ADCY5 APC2 DUSP2 PPP2R5D CCL22 BDNF MEF2C DUSP3 DUSP7 GNB1 CACNB1 PRICKLE2 CACNG7 PLCB3 GPC4 NFATC4 GNG13 CX3CR1 GNB5 CX3CL1 LAMTOR3 TGFBR1 MAP2K3 PLA2G12A CTNNBIP1 VANGL1 DAAM2 CACNG3 FGFR3 CAMK2G MAP3K7IP1 DVL3 CXCR3 CREBBP RELA SOS1 PXN STAT3 PMC4142057__F1 Activation of NFKB signaling through canonical and alternative pathways LTB RELB CD40 TNF PMC4142057__F2 NFKB and p53 antagonises each others activity MDM2 ATR PMC6350063__F1 Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival CASP3 LIF CCND1 STAT3 HES1 PMC10605306__F1 Interleukin-33 signaling pathway IL33 TRAF6 IRAK4 MYD88 PMC4059820__F2 Signaling through T1R2/T1R3 in type II cells of taste buds, in the gut and in the B cells of the pancreas PLCB2 TRPM5 PMC2632675__F3 Cell cycle pathways in S TEN1 H1-1 DAO MBP PMC4517052__F1 Main metabolic pathway in the bioactivation and DNA adduct formation of BaP in lung MPO CYP1B1 CYP1A1 PMC4074570__F3 Regulation of receptor-mediated endocytosis by CRL pathways IFNE SKP1 IFNAR1 RBX1 PMC3900881__F3 Sugar for the brain: the role of glucose in physiological and pathological brain function TIGAR HEL-S-162eP PMC5840209__F3 Apoptosis signaling pathways BMP6 BAD BIK FSHR MCL1 BAX PMC5418249__F1 PD-1:PD-L1 mechanisms between T-cells and tumor cells APC ZAP70 PTEN MTOR PMC11904106__F1 Targeting intracellular autophagic process for the treatment of post‐stroke ischemia/reperfusion injury TSC2 EGF TSC1 RHEB PMC3904431__F3 Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges KIT MMP2 HOXD10 BCL2 HOXA1 PTEN MCL1 SP1 CEBPB CDK6 SOX4 CDC42 PMC6137199__F6 Predicted target genes of miR-125a-5p and let-7e-5p in the Inflammatory response molecular network CCR2 PTGFR SULF2 CD6 ICAM2 TICAM2 MAPK14 OSCAR SMAD4 ULBP1 OSMR CXCL13 MAPK12 CYLD SOCS4 CRP IL2 ABCG2 IL10RA ICOS IL10 KIT GALNS FOS PTGS2 VEGFA FES FPR2 CTLA4 TNF TSLP KLF3 ITGAM PTPRO TRAF1 ABCC1 KLF4 F7 JAK3 SYK ITGAX OSM IRAK3 PPARG PMC7377858__F6 circRNA-miRNA-mRNA network CORT SPOPL APC RERG TOPORS FIGN PMC3544775__F3 Laminin-211 in skeletal muscle function BAD GRB2 BAX PMC5543893__F8 Involvement of KRT23 in the cell cycle: G1/S check point pathway CDKN1A SMAD4 DACH1 KRT23 CEBPB PMC7835019__F9 Proposed model depicting the involvement of the eNOS/cGMP/PKG pathway in PF activation KIT MTOR FBXW7 PMC9071930__F7 Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NFKB Signaling Pathway following Stimulation of the Inflammatory Microenvironment RUNX2 MMP9 ID1 SOX9 PMC3411066__F6 Formation and function of 16:1-PI in the signaling of the lipokine 16:1 in Swiss 3T3 cells HMFN0839 GPAT4 PC GPAT2 LPA PMC5481559__F14 Proposed model for persistent fibrosis in mice after lung injury NOX4 HYAL3 HAS2 PMC9004589__F6 Astrocytes: The Housekeepers and Guardians of the CNS TRPC4 TRPC1 TRPV4 TRPC5 TRPA1 PMC8363454__F6 Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NFKB Signaling Pathway PHLPP2 RAC1 TIRAP PMC9095844__F1 Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases BTK CCR3 LYN SYK PMC4526652__F7 Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue PMC9563430__F9 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression BAD FANCD2 CDKN2C LAMTOR3 MYC NBN RB1 BCL2L11 RALBP1 TNFSF6 ATM MDM2 SRC PRKDC JUN RBL1 BAX RBPJ FOS APC MAP3K7 DIABLO AURKA CBL CASP3 CREBBP EP300 HP BBC3 SUFU FADD SMAD1 DKFZp781O1323 CYCS CDC42 PMC9563430__F5 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression BAD FOS MAP3K7 RB1 CCNC AURKA DVL1 NLK MAX ATM BBC3 SUFU SRC BCL2 PRKDC FADD BAX PMC9247880__F2 Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma BRAF PDGFRA DKFZp781B1423 EGFR MYC PTEN MTOR CDK6 TSC2 NF1 TSC1 ERBB2 CDK2 MDM2 CDK4 PMC3824005__F3 Canonical and noncanonical functions of the apoptotic machinery NMNAT2 BAX PMC3314482__F1 Chk’ing p53-deficient breast cancers NOG ATM CDK2 ATR PMC3824005__F1 Core components of the apoptotic machinery TNF DCC BAX PMC4095906__F3 TLR and BCR signaling and integration in CSR and antibody responses TLR9 RELB TRAF3 TRAF6 IRAK4 PLCG2 MYD88 MTOR HOXC4 TLR4 BCL10 BCR AID CD40 TRAF2 TAB3 MAL PMC3656649__F1 ENDOCRINE RESISTANCE IN BREAST CANCER EGFR SRC SP1 PMC8493254__F5 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep IFIT3 NGF DHX58 IRF3 RTP4 TRIM25 TLR3 ZBP1 NCR3 DLX3 MX1 IRF6 ISG15 TLR4 TRAF4 IFIT1 PMC8493254__F6 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep RSAD2 STAT2 IRF7 IRF9 IRF3 IFNAR1 TRIM25 ZBP1 GAS2 STAT1 ISG15 ZC3HAV1 NFKBID SOCS4 SOCS7 IRF2 IFIT1 PMC12192923__F2 The cGAS-STING pathway in health and cancer therapy TBK1 CGAS IRF3 PMC7998005__F8 miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease ROCK2 ADD1 FOXD3 PMC7554708__F3 Representative pathways involved in the metabolism of diacylglycerol (DAG) and phosphatidic acid (PA) PC LPA LPP PMC7282166__F1 Protein-protein network of the 186 exposure genes NAMPT GNAL GYPC DUSP2 SLPI RAN OSM ADM SYT2 CLU PMC9304296__F2 DNA damage response proteins in canine cancer as potential research targets in comparative oncology PALB2 TOPBP1 BRCA2 RAD51 ATR BRCA1 PMC6819196__F8 HIPPO SIGNALING CONTROLS NLRP3 ACTIVATION AND GOVERNS IMMUNOREGULATION OF MESENCHYMAL STEM CELLS IN MOUSE LIVER INJURY NLRP3 MSC LATS1 XBP1 LATS2 PMC9304296__F4 DNA damage response proteins in canine cancer as potential research targets in comparative oncology TOPBP1 ATRIP MDC1 ATR PMC5460284__F4 Network model describing association of hyperactivated mTOR signaling with developmental and morphological defects in forebrains TSC1 MVD PMC11663879__F4 Molecular mechanism and RNA modification with their functions in Macrophage YTHDF2 STAT1 WTAP PMC6121658__F1 MDSCs expansion is regulated by several factors in vivo microenvironment AHR IL33 MTOR STAT3 PMC6997465__F1 Immune system and nociceptor activation NAV1 NGF TRPA1 TNF MTOR TRPV1 PMC3757395__F1 Scheme of miRNA processing pathway DROSHA PMC8389290__F7 Uncovering Mechanisms of Zanthoxylum piperitum Fruits for the Alleviation of Rheumatoid Arthritis Based on Network Pharmacology UBC NPB EGF PLTP DAO MAX UCP1 AQP7 HEL-S-28 TNF PMC9362873__F1 LILRB4, an immune checkpoint on myeloid cells TH BCR LILRB2 LILRB4 ARG1 APOE PMC10385954__F13 Putative mechanism of artemisinin neuroprotective action against 6-OHDA and MPP+-induced neuronal injury FYN GRB2 SRC PMC4835965__F4 ER stress and autophagy in AD NLRP3 EIF2S1 HEL-S-89n HEL111 ERN1 GSK3B CSTB MAP1LC3B2 IL1B CLU PMC5406529__F1 T cell immune checkpoints for anti‐tumor immunity ZAP70 CD80 CTLA4 PMC8636279__F2 Helminth extracellular vesicles: Interactions with the host immune system IL33 MTOR PMC5965688__F8 Nm23-H1 in cell cycle regulation and apoptosis CCND1 CDK4 CDK6 BAX PMC7253339__F1 NPC and associated factors RCC1 RAN PMC3386226__F8 Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner TOPBP1 ATRIP ATR CRB2 PMC4030989__F1 Sphingolipid pathway and basic structural units of sphingolipid biosynthesis SGPP1 CERS3 LASS1 CERS5 SPHK1 DEGS1 CERK SPHK2 DEGS2 CERS2 CERS6 SGPP2 PMC9315226__F4 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? LRRK2 BRAF BRD4 PMC4190013__F1 Signal transduction pathway for type I IFNs and a summary of key ISG effects on the virus and mucosal immune response during influenza RNASEL RNASE1 STAT2 IRF7 IRF9 CXCL10 TYK2 IFNAR2 PMC5511157__F6 Mediation by Menin of milk protein synthesis through the PI3K/Akt/mTOR signaling pathway in mammary epithelial cells PRLR EIF4E RPS6 MTOR PMC3514012__F5 IPA generates IL-17C interactome IRAK2 LCN2 CXCL2 CCL2 IFNG NFKBIA NFKB2 NFKB1 IL23A IL36G IL17C TRAF3IP2 CSF2 IRF-1 PMC3888473__F3 Top genes from SNP comparative analysis MUC1 NFE2 HGF MYC BCL2L1 CYP7A1 TNFSF6 XDH CYP1A1 ABCC5 ABCG2 NOS2 ABCC6 ABCC2 CYP4A11 ABCB1 IL1B BAX CYP2B6 PTGS2 MMP9 NFE2L2 VEGFA IL6 TNF CYP2A6 FOXO1 CYP2E1 SLCO1B1 CYP2J2 CYP3A4 VCAM1 ABCG1 ABCC1 NR1C2 BCL2 BNIP3 PCNA PMC3888473__F4 Pathway analysis on SNPs that affect gene expression and drug response SLCO4C1 CHST3 NR3C1 GUGU ACHE TNF SLCO1B1 CYP3A4 CYP4F12 VTN HNRNPC NR1C2 HNRNPA2B1 SP1 SLC24A3 NR1H4 RPS15A PMC8481945__F2 Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy BRAF NFIB SMAD2 EGFR MYC SMAD4 PAX3 HMGA1 NGFR NOTCH1 ROR2 EZH2 AXL PMC4574966__F3 Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease MARCKS PLK1 NUPR1 E2F6 ATXN3 HEL-S-101 CNTF PABPC1 AEN ACO2 TP73 RPS6 YWHAG APOE PMC5347792__F9 Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway SHH SMO PMC4348060__F5 Differential network of breast cancer Cell Cycle pathway between early recurrent and non-recurrent patients CDC14B GADD45G SFN CDKN1B CDC25B RB1 SMC1A MCM5 CREBBP MCM6 ATM BUB1B HEL-S-93 PMC3716752__F1 Toward understanding the genetics of regulatory T cells in ovarian cancer APC RGS1 CD80 CTLA4 TNF FOXP3 PMC9534897__F4 Extracranial arteriovenous malformations demonstrate dysregulated TGFB/BMP signaling and increased circulating TGFB1 HEY2 SMAD6 SMAD1 HES1 PMC6304875__F1 General overview of the autophagic pathway and its regulators ULK1 ULK2 MTOR PMC7600068__F2 Potential mechanism of radiation-induced abscopal effect ATM EGFR PMC4619526__F1 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study NR1i1 CYP2R1 DHCR7 CYP24A1 CYP27B1 RXRA PMC9315226__F2 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? BRAF MEF2B MAP3K2 FOS MAPK7 NRAS MAP2K5 MEF2C MEF2D PMC6769649__F3 Ligand-dependent EGFR signaling pathways EGF EGFR GRB2 SRC CBL PMC9315226__F3 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? IGF1R BRAF FOS EGFR SRC PMC7950238__F5 Signaling pathway diagram NLRP3 TXNIP GATA4 GSDMD PMC9315226__F1 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? BRAF FOS CDC2 PMC4309433__F1 Metabolic network of tomato cells CS SCO1 CIT TK1 MAL HEL-S-162eP PMC7642048__F1 Mechanical stretch-induced signaling pathway in VSMCs IGF1R HDAC7 SRC AIM2 SIRT1 PMC8846306__F2 Running ‘LAPS’ Around nLD: Nuclear Lipid Droplet Form and Function HMFN0839 GPAT4 DGAT2 LPA PMC7988785__F1 An update on brown adipose tissue biology: a discussion of recent findings FGF21 FGF6 CXCL14 IL17RC TGFBI FGF9 PMC10380532__F2 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy TTI1 RICTOR MTOR DEPTOR MLST8 PMC3912166__F1 Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs A4GALT UGCG B4GALT5 ST3GAL5 PMC10380532__F3 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy IL33 MTOR STAT3 PMC540032__F1 CellDesigner () diagram of the insulin/IGF receptor signaling pathway IRS4 NGF PDK2 PTEN MTOR IRS1 INSR PMC3868461__F7 Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter CIT MAL PMC7191095__F3 Main signal pathways of YTHDF2 in human cancers YTHDF2 SOCS2 METTL3 MAP2K4 EGFR CDH2 IL1B PMC2045534__F6 Schematic model of the role played by GADD34 and the mTOR pathway in the suppression of viral replication TSC2 TSC1 MTOR PMC10741975__F5 Compound-pathway network has 41 points and 151 lines PIK3CD CCR2 MAPK9 CTSK CCR3 GSK3B MAP3K5 TNF MTOR CXCR3 PIK3CA MAP3K14 CDK4 JAK3 PMC7267062__F2 Death receptor apoptotic pathway in cancer induced by plant polysaccharides FADD BAX PMC10741975__F7 Chemokine signaling pathway and PI3K-Akt signaling pathway influenced by esaxerenone PIK3CD EGF CCR2 CCR3 CDKN1A CDK2 CDKN1B EGFR SRC JAK3 IL6 IL6R PMC7267062__F1 Mitochondrial apoptotic pathway in cancer induced by plant polysaccharides BAD BAX PMC7555774__F3 Inhibitory signaling events against AngII/AT1R-mediated senescence in VSMC DKFZp686F0183 SIRT1 SIRT3 PMC8802973__F1 Safety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL) JAK3 TNF STAT3 PMC3384423__F1 MTOR signaling pathway NF1 TSC2 RICTOR TSC1 PTEN MTOR RAN DEPTOR RHEB PMC8669293__F6 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus ZNF148 SULT2A1 OTC SP1 CP PMC8669293__F4 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus FLT4 NTRK3 MATK CP PMC6600524__F1 Schematic representation of androgen deprivation therapy (ADT) or androgen receptor (AR) antagonist in mediating therapeutic resistance and neuroendocrine (NE) differentiation of prostate cancer (PCa) LIF SPDEF CCL2 PTGS1 TGFBI PMC8194090__F7 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation RUNX2 SOX9 PMC6944213__F6 Genotype, phenotype, and dose effects on Bcl6 inhibition upstream of the secreted factors canonical pathway IL10 IL12A IFNG BCL6 PMC8194090__F5 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation RUNX2 SMAD2 SOX9 PMC8194090__F3 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation IHH RUNX2 SMO SOX9 PMC2949081__F1 Summary of the RAS incorporating the Ang peptide family and physiological effects mediated via ATR subtypes AMBN ATR ACE2 PMC3770247__F1 Hedgehog signaling pathway, a morphogenic signaling pathway important in embryogenesis, tissue differentiation, cell growth and development CSK SHH SMO PMC8194090__F2 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation RUNX2 BMP2 APC GSK3B LRP5 LRP6 SOX9 PMC7555140__F1 Small heat shock proteins (sHSPs) regulate apoptosis in the extrinsic and intrinsic apoptotic pathways HEL-S-102 CASP3 FADD PMC7249327__F3 From progesterone to Cdk1 activation: the scattered elements of a not fully understood signalling pathway MOS FIG4 ARPP19 CDC2 MYT1 PMC7552005__F1 PKR at the crossroads of virus sensing, innate immune signaling, and stress response pathways TBK1 TRAF5 ATF4 EIF2A TRAF3 TRAF6 IRF3 TRAF2 MAVS PMC5467017__F8 Working model portraying the effects of WNT/Beta-catenin signaling in PTENWT melanoma cells under nutrient starvation conditions APC PTEN PMC11851658__F1 Pexophagy-related peroxisomal proteins PEX5 PEX16 MTOR PEX3 EHHADH PEX13 PEX14 PMC4017408__F1 Wnt signaling pathway APC GSK3B PMC6902583__F6 Target network of bradycardia REN GDA TRIM21 HEL-S-99n PROC NOX4 CHRM5 CHRM2 ANGPT2 NPPA SEMA3A ADRB1 OPRM1 ADRA2C RGS4 ADRB2 ARHA RAC1 CYBB HCN4 AQP9 KCNA1 PLN CHRM4 ADRA1B CACNA1G CHRM3 ADRA2A GJA1 SP4 CHRM1 UTS2 AVP HCN1 NACA2 ADRA1D ADRA2B ADRB3 PMC11851658__F2 ROS function as signaling mediators in pexophagy TFEB PEX5 ATM PEX2 PMC5541090__F1 NREP, HIPK2, PRDM16, SMAD3 and their roles in the canonical TGFB signalling pathway PRDM16 HIPK2 SMAD2 TGFBR1 TGFBR2 SMAD4 NREP PMC7462746__F6 cGAS-STING Pathway inhibition by HCQ and CQ: DNA sensor cGAS (cyclic GMP-AMP synthase) can recognize DNA of viral/bacterial origin and synthesize a dinucleotide molecule, cGAMP (2′, 5′-cyclic GMP-AMP dinucleotide) CGAS IRF3 TNF PMC2647628__F1 CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses CXCL13 IRAK1 CXCR4 RELA RELB MYD88 CXCL12 PMC7906184__F10 Graphic depiction of the conclusion from the present study LRRK2 SP1 PMC7779278__F3 Pyruvate dehydrogenase kinase (PDK) in immune cell metabolism PDC CD80 HIF1A CD36 HEL-S-5 PMC3348846__F2 Leukocyte recruitment to sites of injury/infection: dominant role of ROS HMGB1 TLR4 VCAM1 PMC4588544__F3 Current models for mitochondrial longevity EIF2A MTOR TAF4 PMC3348846__F3 Role of Rac1/RhoA balance in endothelial barrier integrity: impact of ROS and NO ARHA RHO RAC1 CDC42 PMC8546260__F1 TNFA/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response RIPK1 TRADD RIPK3 RIPK2 TRAF2 FADD PMC9294282__F3 Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair PALB2 RIF1 KEAP1 APC RNF4 UHRF1 USP11 FBXW7 BRCA1 RNF168 RNF8 BRCA2 RAD51 RFWD3 PMC3050844__F5 Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes CTCF CDK3 MAL PMC5337806__F5 TGFB signaling pathway BAMBI E2F4 SMAD2 TGFBR1 SMAD6 SMAD4 SKP1 ARHA TNF RBX1 SMURF1 IFNG SMURF2 SP1 SMAD1 DKFZp781O1323 PMC7779278__F1 Pivotal role of pyruvate dehydrogenase kinase 4 (PDK4) in regulating the metabolic switch between glucose and fatty acid oxidation in skeletal muscle in physiological and pathological conditions PDC PDK4 IRS1 FOXO1 CD36 HEL-S-5 PMC5337806__F3 MAPK signaling pathway CD14 EGF NGF MOS FLNA EGFR GCK TRAF6 CDC25B NLK MAX ECSIT RAF1 BDNF MEF2C JUN CDC42 PMC8067602__F4 Necroptopic signaling pathway TRADD TRAF2 FADD MLKL PMC5629629__F8 Proposed model of the cell autophagy induced by SAHA and TRAIL DR5-CTSB in breast cancer cell lines MTOR PMC9684732__F4 Endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy ELF2 ATF4 TG TRAF2 XBP1 TRAF4 PMC2938097__F6 TNF/Fas/TRAIL signaling pathway FAF2 DEDD HDAC7 TNFSF13 CRADD RIPK2 TNF TRAF2 FAF1 PMC9544065__F12 Revisiting the therapeutic potential of tocotrienol EIF2A TRAF3 BCL2 BAX PMC4369380__F1 Distinct Integrin-Dependent Signals Define Requirements for Lytic Granule Convergence and Polarization in Natural Killer Cells HEL-S-28 SRC PMC5406714__F1 Targeted Inhibition of Hepatocyte Growth Factor (HGF)/c-Met Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) HGF GRB2 STAT3 PMC6895828__F4 The cancer signaling pathway and protein network analysis of these up-regulated targets and the prognostic model of the ten-hub gene signature CHST11 IL21R XCR1 CCR2 P2RY1 TNFRSF14 CHST13 RELT BIRC5 IL34 P2RX7 F2RL3 LPCAT1 OSMR RGS14 CACNA1A TNFRSF9 TNFSF6 FLT1 KDR KSR1 TNFSF14 CCR7 HK2 CXCL11 ELMO1 ANGPT2 MAP3K1 PLA2G6 IL20RB VEGFA IFNAR2 CYBB IL12RB1 IL10RB PLCB4 SHC2 EDNRA TNFRSF1B DUSP10 TNLG8A ABCG1 CXCL9 NCF1 TNFAIP3 TGFA BDNF TGFB1 CACNB1 TRADD CX3CL1 EGFR CSF2RB NOTCH3 INSR LCP2 PDGFD NGFR BIRC3 DLL4 CD40LG CCL28 IL2RB BAX PLB1 HRH2 IGF2 CCR4 IL24 TNLG7A CFTR TNFRSF25 CARD11 EGLN3 IL7 RASGRP3 BBC3 LCK ZAP70 CD40 JAK3 CR2 CSF1 IL18RAP JMJD7 SHC1 INHBB RASAL3 RASGRP4 PMC4040907__F6 The impact of 5q deletion upon myeloid cell fate EGR1 EGR2 NAB2 IRF8 CEBPA HNRNPA0 GATA2 PMC4774567__F1 Target function of MALAT-1 in cancer SFPQ CCND1 SP1 pp6425 SOX17 CDK6 BAX PMC7569310__SF1 Transient Receptor Potential Ankyrin-1 and Vanilloid-3 Differentially Regulate Endoplasmic Reticulum Stress and Cytotoxicity in Human Lung Epithelial Cells After Pneumotoxic Wood Smoke Particle Exposure ATF4 EIF2A ATF3 XBP1 DDIT3 PMC7565963__F1 Hedgehog signaling pathway BOC KIF7 SUFU PTCH1 SMO PMC11967251__F7 Mechanism graphic in this study VEGFC IGF2BP3 SRC STAT3 PMC3990910__F3 Mechanisms of Notch signaling silencing in AML NOTCH2 HES5 MAML1 MAML3 LFNG PMC3990910__F1 Mammal Notch receptors, ligands, and canonical activation pathway NOTCH2 EGF NOTCH4 NOTCH1 NRARP ADAM10 NOTCH3 PMC6539122__F7 Interaction network of proteins involved in cancer, immune system, and signal transduction pathways NCOR1 MAPK8 HEL-S-1 ETV6 HSPA2 MYC MAPK14 NCF4 IRAK4 CHD4 PIP4K2A MYH10 CDC34 RASA3 STAT5B PDPK1 BMP2K CDK6 MTMR1 PSMD13 DAPP1 CSF1R SCIN POLR2B PSMC6 APAF1 INPP5D KSR1 CCR7 SIN3A ARPC1B CASP8 PGAM1 UBE3A HEL70 RUVBL1 HEL-S-28 GNA13 MAP3K5 CYBB VDAC3 DDB1 ARPC4 GNA11 PRKCB ARPC2 RPS6KA1 AGPAT4 CXCR4 CTNND1 SNRPD1 ADCY5 ATP2A2 PSMD2 PSMD1 GNB1 CDC42 MYH9 PLCG1 CHUK RASA2 CTBP1 TPR MAP2K3 CD81 DTX3L BTK IL18 CDC2 PTPN6 DDX5 YWHAG JUN PDE3B ACVR1 CAMK2D RPS6KA5 SKP1 CAMK2G SSB PRKD3 HDAC1 DVL3 HEL-S-162eP PTPRC PSMD12 SDC4 MAP3K2 ZAP70 ADA SYK RAF1 DOCK2 TRAF2 VAV2 STAT3 PMC7514027__F6 Vanadium-protein complex inhibits human adipocyte differentiation through the activation of Beta-catenin and LKB1/AMPK signaling pathway EPO PMC3393821__F2 Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: Preliminary findings IL21R RELB IFNAR2 TNF IFNAR1 IL15 RIPK1 NFKB2 TNFRSF1A BCL2 JAK3 IL-21 JAK1 TRAF2 NFKBIE STAT3 PMC3384423__F4 CRLs/SCF E3 ubiquitin ligases regulate mTOR pathway TSC2 TSC1 CUL7 VHL MTOR RBX1 CUL4A PHLPP1 PMC4456188__F1 Mechanisms by which Beta-cell failure an apoptosis occur are complex, not completely unraveled and involve the interplay of numerous factors and conditions MAF PDX1 TSC2 TSC1 GSK3B ATF3 MTOR IRS1 PMC12004233__F5 Significant differentially expressed unigenes enriched KEGG pathway analysis by the comparative transcriptomic analysis of Mro-IR knockdown EGF GNRHR SMAD2 TGFBR1 EGFR EHD2 TGFBR2 INS MTOR INSR CBL MDM2 GRB2 LDLR CCND1 OCA2 PMC4389579__F1 Conceptual model of general lifestyle factors, salient CHD pathogenetic pathways and CHD hallmarks TH NLRP3 COX1 IGF1 MPO VCAM1 TF PMC4509079__F1 BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways SALL4 MYC BMI1 PMC8038495__F9 Proposed scenario of the altered mechanisms driven by HFD/IPA treatment OGA OGT IRS1 PMC5799234__F1 C-type lectin receptor (CLR) signaling in fungal recognition NLRP3 CARD9 TLR4 BCL10 RASGRF1 SYK IRF3 RAF1 MYD88 IL1B PMC9105460__F1 Immunotherapy for HER2-Positive Breast Cancer: Clinical Evidence and Future Perspectives HLA-E RET APC CTLA4 PMC3448082__F1 A simplified model of the feeding regulation hypothesis involving the hypothalamic neuropeptide signaling pathway CCK POMC PYY PMC5413580__F1 Generalized schematic of checkpoint molecule structure and expression, and the balance between stimulatory and inhibitory signaling HMGB1 SIRPA CD47 APC CD200 HEL-S-92n CD80 LAG3 CD200R1 CEACAM1 PMC4445746__F3 Predicted interactions between miRNA and mRNA targets within addiction relevant signaling pathways PRKCE PMC8175775__F6 Identification of Tumor Necrosis Factor-Alpha (TNFA) Inhibitor in Rheumatoid Arthritis Using Network Pharmacology and Molecular Docking TRADD TNF FADD PMC2705893__F1 Protein kinase Cι: human oncogene, prognostic marker and therapeutic target EGF PAK1 BAD HGF EGFR MYC SRC RAC1 PMC6030972__F6 Interactive KEGG diagram for Signaling pathways regulating pluripotency of stem cells TH BAD TCF3 MAFK GSK3B GRB2 HRAS TG INHBA ELL PMC4558313__F4 Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes TRPV4 PC HEL-S-11 MCU CRTC2 PMC5992426__F2 Venues of prenatal alcohol exposure (PAE) altering neuroinflammation CCR2 TLR4 VCAM1 GFAP CCL2 BDNF IL1B PMC9412785__F1 RAS signalling pathway and therapeutic approaches to target this pathway in cancer TSC2 TSC1 WEE1 SOS2 HEL-S-28 GRB2 CDK4 PTEN SOS1 AURKA RHEB PMC5108086__F3 Toll-like receptor signaling pathway color-tagged by co-morbidity findings CD14 CTSK TRAF3 SHE ARHA TLR1 CRK TIAM1 TLR8 ITK PDC TLR7 TLR4 GRB2 LBP CD40 IL4 GAL FADD CP TIRAP CDC42 PMC8864228__F2 Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases HEL-S-62p GDNF AQP4 IL1B ROS1 AQP9 PMC8003205__F2 CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 screens identified genes involved in Gb3 biosynthesis, with a schematic diagram of the Gb3 biosynthesis pathway and a summary of the top genes identified in CRISPR/Cas9 screens AHR A4GALT UGCG TM9SF2 LAPTM4A B4GALT5 TMEM165 KDSR PMC7370165__F7 M2 polarization of tumor‐associated macrophages is dependent on integrin B3 via peroxisome proliferator‐activated receptor‐G up‐regulation in breast cancer FASN CD36 PMC6061668__F1 Endothelial injury pathways in thrombotic microangiopathies MPO VCAM1 CFH VWF TF CFI PMC3322527__F7 TGFB signaling pathway overlaid with differentially expressed genes NODAL GSC SKI PMC7479667__F3 Indirect and metabolic effects of stress on T cells CD80 MTOR PMC5038883__F6 Proposed mechanism by which V8 induces apoptotic cell death in human multiple myeloma RPMI 8226 cells ATF4 EIF2A BAX PMC4738049__F2 Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection IL21R TYK2 JAK3 IFNAR2 RAG2 PMC4549294__F14 UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFKB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFKBp65 Ser276 Axis EGFR GSK3B TRAF6 PMC6335097__F9 Simplified signaling pathway for vasopressin-mediated sodium-chloride cotransporter (NCC) regulation in distal convoluted tubule (DCT) cells OSR1 SGK1 PMC6519110__F1 Intracellular NAD+ metabolism in eukaryotic cells NAPRT NAMPT NMNAT1 NMNAT2 NNMT NMNAT3 NADK2 NADSYN1 PNP PMC3423373__F3 Transcriptional Programs Controlling Perinatal Lung Maturation PIK3R1 SOCS3 EFNA1 RB1 SOX17 E2F3 SMARCC1 BATF CBX2 BMPR2 KDR BCR APEX1 TIMP3 FGF10 EZH2 TGFBR3 HMGB2 PTPRM APOE F11R TMOD1 HELLS HCLS1 RRN3 SET ADRB1 PMF1 FOS HEL-S-28 ORC6 MYEF2 MDC1 PDE4DIP VEGFA HBEGF IL8RB GUCA2A ENG L3MBTL2 CENPE CREB3 EDN1 CDC20 BRCA2 CDK2 KLF2 TUBA1B PCNA HEL-S-62p PRKCE ACVRL1 F2R BLM EGFR CSF3R TEAD4 NME2 CSF2RB DBF4 ORC2 CITED2 CHEK2 AHR ECT2 ATM F3 THBS1 GMNN B4GALT1 NFYB HMGB1 EHMT1 MAP3K6 CBX3 BMP2 CCR4 DEK CHEK1 GATA2 NRP1 HEL164 PTPRE JUND TRIM28 PPARG PMC4657041__F9 The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia EP300 DROSHA SMAD4 RB1 PMC7721010__F8 Schematic regulation mechanism of miR-361-3p on lymphoma cell behaviors CCND1 WNT10A PMC6029413__F2 Multiple roles of the extracellular matrix (ECM) in modulating the cancer-immunity cycle VCAN CCR7 HEL-S-92n PMC7738607__F2 Skin immune response in dermatophytosis EGF CXCL1 EGFR CXCL8 TNF IL23R IFNG NLRP3 CARD9 IL17RA SYK IL1B STAT3 PMC4075065__F1 Insulin/mTOR signaling pathway and also the extrinsic modifiers that are present in diabetes IRS4 MTOR IRS1 AKT3 PMC6027159__F11 cGAS/STING signaling pathway CGAS TRIM32 TRIM56 PMC6027159__F12 TCR signaling pathway USP2 BCL10 SHARPIN TRAF6 MAP3K7IP1 TAB3 PMC6027159__F10 RIG-I/MAVS signaling pathway TRAF5 SHARPIN TRAF6 MAP3K7IP1 TRIM25 TRAF2 MAVS TAB3 PMC3376961__F1 Annexin A2 pathway in pancreatic cancer invasion and metastasis ANXA2 RHO PMC2908610__F1 Death receptor pathway via Fas ligand and Fas receptor FADD PMC5571522__F7 Diagram of CPT inhibiting IGF‐1/AKT/mTOR pathway via suppressing the ERA in breast cancer IGF1R IGF1 PTEN IRS1 PMC6027159__F13 Genotoxic stress signaling pathway RIPK1 ATM SHARPIN TRAF6 MAP3K7IP1 TAB3 PMC9482139__F2 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets HEL-S-133P HK2 PMC12110588__F3 Structure, conserved motifs, and anti-interferon activities of programmed death-1 ligand 1 JAK1 STAT3 PMC6995521__F7 Differentially expressed proteins in the Cyp27a1−/−Cyp46a1−/−Soat1−/− vs SLC14A1 LAMTOR3 BPHL GAA HEL-S-5 PMC2715971__F2 Interaction between insulin and interferon-alfa signaling pathway STAT1 STAT2 TYK2 IFNAR2 JAK1 IFNAR1 PMC9482139__F1 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets FH PSPH HEL-S-133P PHGDH FASN GLS PMC6626719__F3 Aberrant activation of the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma APC GSK3B LRP5 CCND1 LRP6 CAD PMC6838672__F3 High-Throughput Assessment of Kinome-wide Activation States MAF NLK BRAF CHKA CDK9 CDC42 PMC7226390__F7 Schematic abstract of the oncogenic and CSCs-promoting role of MALAT1 in HCC TWIST1 STAT3 PMC6520011__F1 Impaired ribosome biogenesis RPL11 MDM2 RPL5 POLI PMC8022952__F1 Expected flavonoid biosynthesis pathway in maize PMC3757426__F1 Epidermal growth factor receptor (EGFR) crosstalk ERBB4 IGF1R ERBB2 ERBB3 EGFR SRC PMC9506007__F2 Regulation Mechanism of Plant Pigments Biosynthesis: Anthocyanins, Carotenoids, and Betalains MYB PC RFWD2 PMC4792076__F7 Schematic view of B3 integrin–GSK3B and BMP-2–Smad cooperation BMP2 HEL-S-28 SRC SMAD1 PMC10993494__F9 Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development PIK3R1 CXCL8 MYD88 PMP22 IFNG MMP3 INPP5D ACACB LPL FURIN NOS2 SP1 ADM PNPLA3 CYP46A1 ANGPTL4 Nbla10317 CCL4 ELOVL6 CEBPA PPP1R10 TNF ATP5IF1 USP48 FOXO1 STRADA CCKBR RXRA ZNF117 EDN1 TMEM169 LEP INSIG1 IGF1 ARPC3 FADS1 TGFB1 CD36 CDC42 NR5A2 MPO PGR CEBPB IL1B PNPLA2 FGF7 FASN PTGS2 RAC1 IL6 PMAIP1 PPARG FADD PMC7910618__F4 Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/Beta-catenin/PPARD signalling CXCR4 NR1C2 PMC3368988__F2 Sites of PP2A activity within the network of ERK activation KSR1 SRC RAF1 PMC138773__F1 EGFR transactivation by GPCRs and cytokine receptors EGFR SRC PMC5439543__F1 CHEK2 pathway NEK6 ATM FOXM1 BRCA2 CDC25B BRCA1 PMC5644640__F1 Summary of potential beta adrenergic signaling pathways in canine hemangiosarcoma and human angiosarcoma PTGS2 MMP9 SRC PMC4407294__F1 PI3K/AKT/mTOR and the RAS/RAF/MEK/MAPK pathways TSC2 TSC1 GSK3B GSK3A PTEN FOXO1 RHEB PMC4407294__F2 Molecular pathways regulating breast cancer stem cells (CSCs) CXCR1 RELA EGFR SRC IL8RB SMO PTEN STAT3 PMC4754414__F1 Pathways for molecular targeting in prostate cancer radiotherapy ATM BRCA2 MDC1 RAD51D RAD51 PTEN HIF1A MTOR ATR XRCC3 MRE11A CYP17A1 PMC2729812__F1 Proposed pathway from pressure overload to LV hypertrophy and fibrosis ADAM12 HBEGF TGFA PMC10506215__F3 PTM of PGK1, including acetylation, phosphorylation, ubiquitination and O-GlcNAcylation HDAC3 MTOR HEL-S-68p PMC2908510__F3 Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family IGF1 ERBB2 GAB2 EGFR IRS1 PMC8010917__F2 NLRP3 activation pathway NLRP3 MYD88 IL1B PMC4029299__F3 Gene- and pathway-based connectivity map of vismodegib and Gorlin syndrome PTCH2 SUFU SMO PMC4455035__F2 Pericytes, microvasular dysfunction and chronic rejection ANGPTL4 ARHA BDNF PMC8036964__F7 Target-enriched KEGG pathway network for UR alkaloids against AD CCR5 PDE4D P2RX7 GSK3B MAOA ALOX5 DRD1 DRD2 DRD4 MMP3 CSF1R FYN FGFR1 MMP2 CHRM2 NOS2 NTRK2 PSEN2 MAPK10 CDK5 IL8RB HTR7 ADRB2 HTR4 DRD3 SLC6A3 SLC18A2 GABRA5 HTR1A GRIN2B HTR2A HTR6 ACHE MTOR ADAM17 INSR CCND1 CDC2 KIT MMP9 PTGS2 NTRK1 FGFR3 NTRK3 PARP1 CASP3 CHRM3 PSEN1 ERBB2 PSENEN MME APH1B CHRNB2 PMC11848799__F2 Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain ELF2 EFS PABPC1 EIF2A REST MAL PMC11933059__F2 PAM pathway mechanism of action CDK4 PTEN CDK6 PMC8953665__F4 Cholesterol metabolism: from lipidomics to immunology SOAT2 ABCG8 MYLIP ABCG5 DHCR24 APOC2 APOC1 HMGCS1 HMGCR DHCR7 FDFT1 ABCG1 APOC4 LDLR SOAT1 ABCA1 APOE PMC1413813__F8 The signaling pathway regulating the expressions of SMAlpha-actin, SM-MHC, and calponin in SMCs on polymerized collagen in response to PDGF-BB/IL-1B costimulation IL1R1 HEL-S-66 MTOR PMC8953665__F1 Cholesterol metabolism: from lipidomics to immunology STAT1 CYP27A1 CH25H TLR4 LIPA SOAT1 IL1B TLR3 PMC6705791__F5 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study RXRB DBI SCD APOC3 PCK2 EHHADH ADM ACSL3 PMC6705791__F6 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study HLA-E HLA-G HLA-DOB CD74 HLA-B HLA-C TAPBP TAP2 A2M HEL-S-269 HLA-DRB4 HEL-S-283 B2M PSME2 PMC4293272__F2 Cell Signaling Pathways Involved in Hematopoietic Stem Cell Specification WNT16 VEGFA NOTCH1 SMAD1 DKFZp781O1323 BMP4 PMC4729769__F7 Schematic Diagram Depicting the Proposed Role of P-gp in the Formation of Peritoneal Adhesions following an Abdominal Operation SMAD2 TGFB1 PMC5095004__F9 MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma ULK1 MTOR MAL PMC9354322__F3 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment IFNE IRF3 POLI PMC8304710__F2 Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer HEL-S-30 ENO1 PFKL MTHFD2 PHGDH HEL-S-68p HEL-S-162eP PINK1 PSPH HEL-S-51e COXFA4L2 HEL-S-133P MXI1 HK2 MTHFD1L PMC4563985__F3 Proposed mechanisms of activation of proinflammatory signaling pathways in IFN-mediated autoinflammatory diseases TBK1 CGAS STAT2 IRF7 IRF3 TYK2 JAK1 MAVS PMC4177461__F2 Helicobacter pylori mediated downregulation of B7-H2 on gastric epithelial cell inhibits Th17 cell development and facilitates bacterial persistence MTOR ICOS PMC5983750__F1 Molecular pathways involved in senescence IL10 IL1A ATM MTOR PMC3479314__F1 SHEDDING NEW LIGHT ON NEURODEGENERATIVE DISEASES THROUGH THE MAMMALIAN TARGET OF RAPAMYCIN TSC2 TSC1 MTOR DEPTOR RHEB MLST8 PMC9530903__F6 Metabolome and transcriptome association analysis revealed key factors involved in melatonin mediated cadmium-stress tolerance in cotton IVD DLD DBT AGXT2 PMC3811932__F1 Growth factors, insulin, nutrients and energy status regulate the activation of the PI3K/Akt/mTOR signaling network TSC2 RICTOR BAD TSC1 MAP4K3 PTEN MTOR IRS1 RHEB MLST8 PMC9442330__F2 Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders GNPAT DHRS7B PC LPA PXMP2 PMC6473256__F8 Cilia-dependent and independent activation of Gli proteins SUFU PTCH1 SHH SMO OLIG2 FOXA2 PMC12052750__F4 Gut microbiome imbalance disrupts the gut-lung axis NLRP3 IL1B IFNG PMC8117532__F6 Role of chimeric genes in pathway-related gene co-expression modules TH APC PMC3756172__F1 Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway PTGER2 CD14 PTGIR CACNG6 SMOC2 ST7 KPG_011 IL13 PTGER4 LTC4S PTGER3 NAT2 IL5 SLC22A2 TLR3 RS1 NLRP3 TLR4 FCER1A SLC6A12 ADAM33 IL4 SP1 PPARG PMC3196377__F6 Regulator of G Protein Signaling 6 (RGS6) Mediates Doxorubicin-induced ATM and p53 Activation by a Reactive Oxygen Species (ROS)-dependent Mechanism ATM MDM2 RGS6 PMC4032668__F3 Simplified scheme of the DAF-16 signalling pathway in C SGK1 PMC4846574__F12 P21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events SRC RAC1 CDC42 PMC8151260__F1 Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies PIM1 CISH MYC BCL2 JAK3 JAK1 OSM PMC4192477__F2 Numerous proteins that interact with core components of the NOD2 and MAPK signaling pathways were identified as regulators of IL-8 secretion PML PIN1 SNAI1 UBE2L3 BTRC UBE2D3 RNF31 ATF2 USP31 MAPK3 COMMD8 MAPK14 COMMD9 PPP2R1A CARD6 RIPK2 IRAK1BP1 CCDC6 NOD2 JDP2 PLD2 ATM SIRT5 SIN3A hEMMPRIN CDK5RAP3 CAD RUVBL2 MYO1D PPP2R1B CASP10 AVPR2 HDAC1 BRCA1 DUSP10 ELF3 RELA CARD8 HEL-S-93 NCF1 ELF4 MYLK MAVS TERT ITCH PMC3081368__F8 HMGB factors are required for posterior digit development through integrating signaling pathway activities HMGB1 SHH HMGB2 PMC6156463__F2 Metabolism of SAM MTAP MTOR PMC2731678__F3 PAK Signaling in Oncogenesis BAD HEL-S-28 CCND1 PCBP1 RAF1 PMC6156463__F5 Distinct metabolic pathways in cancer cells and their connection to epigenetic modifications NAMPT PCK1 ACSS2 MTOR HEL-S-32 MDH2 HEL-S-26 PDC MTAP F5 ACLY HEL-S-133P HK2 GLS PMC3911500__F7 Schematic model for how S6K1 inhibits TLR2- or TLR4-mediated signaling pathways TLR4 TRAF6 MAP3K7IP1 PMC6999456__F2 Sketches for DCA synthetic pathways C9 C6 PMC1664664__F2 Neurotrophin signalling FRS2 GRB2 RHO JUN PMC5010673__F2 Summary of interactions involved in Wnt signaling cascades inferred to regulate NC biological functions CTBP2 BTRC CTBP1 GSK3B MYC SENP2 CCND3 PYGO1 RHOU NKD1 CCND2 FRZB MAP4 CCND1 DVL2 CTNNBIP1 JUN MAP3K1 APC WIF1 DVL1 VEGFC DAAM1 EP300 AXIN1 BCL9 TLE2 PMC4563985__F4 Mechanisms of NFKB-mediated diseases BCL10 IRF3 RIPK2 NOD2 MAVS TAB3 CARD14 PMC6314674__F1 Metabolic pathways controlling macrophage activation states MRC1 IL16 MRC2 ARG1 IFNG PMC4644679__F1 Hippo signaling pathway and main regulators HEL-S-62p SOX2 GIG8 BIRC5 NF2 AREG VGLL4 MYC RHO AXIN2 PMC4574066__F2 Downstream analysis of Wnt-related gene expression from aged animals predicts a decrease in cell viability and transcription of RNA IL10 CORT IL1A FOSL1 IRAK1 LIF EGFR MYC CCL2 SOX9 BMP4 SERP2 IL18 TLR4 RELA SHH CCND1 ETS2 IL4 PMC4911124__F8 Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection AKAP12 HEL-S-277 HNRNPAB C1QA ISG20 POSTN SGTA SFTPB PMC5745765__F12 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC6279911__F1 MiRNA targets in teleost fish immune system STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 MYD88 MAVS PMC5745765__F10 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC5745765__F11 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC3137710__F2 Chemical ‘Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways APC GSK3B AXIN1 AXIN2 TNKS2 PMC4931673__F3 Circuitry of amino acid signalling to MTORC1 TSC2 RAB1A FLCN TSC1 SH3BP4 FNIP2 TBC1D7 MTOR ARF1 RHEB MLST8 PMC8392360__F1 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches PTEN MTOR IFNG PMC8392360__F2 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches BTK BRAF CTLA4 PMC5814187__F8 Dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model MCM3 UBE2C MCM6 FTH1 ASNS WDHD1 KPNA2 UBE2S PMC4189494__F6 Schematic representation of the negative regulation of TLR3 and TLR5 signaling by MUC1 MUC1 TLR5 IRF3 MYD88 TLR3 PMC6850916__F7 Inhibition of leucocyte migration was included in early moderate exercise‐mediated improvement of inflammation TNLG1B HRH2 FGF2 MYC ALOX5 HEL-S-69p HLA-A NR1i1 CXADR LILRB3 SFTPC P2RY4 THBS1 P2RX1 MMP28 TIRAP MYLK ACR PMC3109866__F1 Converging Pathways in Lifespan Regulation TSC2 RICTOR TSC1 PTEN SGK1 RHEB PMC2881822__F8 ERB Impedes Prostate Cancer EMT by Destabilizing HIF-1A and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading NRP1 VEGFA PMC6167544__F8 Cellar signal transduction pathway induced by GALT IRAK1 IRAK2 APP TRAF6 IRAK4 MYD88 IL1B PMC5061784__F3 HER2/PI3K/PTEN/Akt/mTORC pathway and potential sites for intervention with small molecule membrane‐permeable inhibitors and monoclonal antibodies (MoAbs) TSC2 RICTOR ULK1 TSC1 GRB2 PTEN RPS6 MTOR DEPTOR IRS1 RHEB MLST8 PMC6110865__F6 KLHDC7B and the Interferon signaling pathway STAT1 RARB IFIT3 STAT2 IRF7 IRF9 PIAS1 IFI35 IRF-1 IFNG BAX IFIT1 PMC5839951__F1 IGF-1 signaling mediated cell-specific skeletal mechano-transduction IGF1R IGF1 SOST MSC AXIN2 MTOR PMC6943569__F4 Activation of NF-кB by the canonical and/or the noncanonical pathway RELA RELB REL PMC6567082__F1 Crocus sativus extract affects the cell cycle by blocking the G2 and S phase via p53 and CyclinB-cdk2 proteins BCL2 CDC25B BAX PMC5645510__F2 KEGG pathway “FOXO signaling pathway” is regulated by let-7 miRNA IL10 EGF INS SMAD4 PTEN IL6 INSR NLK ATM HEL-S-11 CDK2 MDM2 KLF2 BNIP3 SKP2 PMC12087082__F4 Purine metabolic pathway ADSL APRT NMT1 NMT2 CYP1A2 ADK PMC3235480__F2 RAF/MEK/ERK and the PI3K/AKT/mTOR signaling pathways are shown BAD PTEN MTOR PMC7564661__F4 Membrane damage signaling NLRP3 TRIM16 TXNIP IL1B PMC5383353__F1 IRS4 signaling in malignant cells and therapy resistance IRS4 NRG2 NRG1 IRS1 PMC4652402__F2 Linear Motifs in T cell receptor signalling pathway hsa04660 IL10 RHO CBL IFNG ITK FYN BCL10 LCK ZAP70 GRB2 IL2 IL4 LAT ICOS CDC42 PMC4516574__F11 Hypothetical model illustrating p53 transgene mediated inhibition of Type I IFN signaling during VSV infection STAT1 STAT2 IRF3 TYK2 PMC9657855__F9 Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R–Ankrd1–P53 Signaling Pathway ANKRD1 MDM2 BAX PMC6121259__F5 Signaling pathways involved in TNF/Thy-1-induced astrocyte polarization and migration SRC TNF THY1 PMC9354322__F1 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment CGAS IRF9 IRF3 TYK2 JAK1 STAT3 PMC12216578__F4 Effect of PM2 FGFR1 RHO CAD LAT PMC11796190__F7 Diagram highlights the distinct mechanisms by which EA and MA modulate hypothalamic function in PCOS SMAD2 TGFBR1 ITGB1 PMC8431827__F2 Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan Beta-Coronaviruses NFE2L2 CXCL8 CCL2 HMOX1 PMC4317626__F1 Complement activation pathways CD59 CD46 PMC10242860__F4 Ferritin in cancer therapy: A pleiotropic tumoraffin nanocage‐based transport TBK1 TLR9 IRF3 PMC7664177__F2 Canonical Pathway of NFKB which represents the pro-inflammatory response, and Keap-Nrf2-ARE Pathway which represents anti-inflammatory response MAF COX2 KEAP1 CSA2 TNF PMC4149376__F8 Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways SFRP4 ChAT MAP2 NGF DBH WNT7A BSN BDNF PMC4892113__F4 Role of Spermidine-TCPTP in the complex dynamics of pro- and anti-autophagic factors TSC2 ULK1 EP300 ATM EGFR PMC9138936__F4 Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer’s Disease UVRAG PMC8276693__F2 Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy STAT1 APC JAK1 IRF-1 IFNG PMC4480265__F2 Sensing of cell death by myeloid C-type lectin receptors CXCL1 CARD9 CXCL2 TNF PMC8253910__F5 Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis CPT2 GBA2 RXRB PPARGC1A RPL21 ACO2 MPC2 CYP1A1 UFD1L PLXDC2 CYP4F8 MISP3 HOGA1 BOD1L1 ROGDI SLC3A1 ETFB SRP14 CHCHD4 HPCAL1 ABHD10 RUVBL1 TRAPPC13 WASHC1 RXRG MGST3 SLC22A10 DECR1 FN3K AMN NR1C1 PABPC4 RPS3A RXRA RMDN2 CDHR2 USP40 ATP6V1B1 LIPA NR1C2 SRSF7 PPARG HABP2 MME PMC9038420__F2 Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress KEAP1 RBX1 PMC6277552__F1 Iron metabolism in prostate cancer microenvironment LIPI IL6 PMC2674123__F10 Signaling cascade of PI3K/AKT pathway BAD GAB2 HEL-S-28 GRB2 CDC37 PTEN EIF4E MTOR RHEB PMC11023972__F3 DDR components regulate cytosolic RNA sensors-dependent IFNs and NFKB signaling pathways TBK1 IRF7 ATM TRAF3 IRF3 MAVS PMC11023972__F4 DDR components regulate NFKB signaling pathways TLR8 TLR7 TLR9 IRF7 ATM TRAF6 MYD88 PMC11023972__F1 DNA-damage response pathways BLM XPC DDB2 DDB1 WRN RECQL POLE RAD17 ATM ATRIP RAD51 XPA ATR H2AX PMC11023972__F2 DDR components regulate IFNs signaling pathways TBK1 CGAS FANCD2 BLM IRF3 BRCA1 ATM BRCA2 TREX1 RAD51 ATR IFI16 BRD4 PMC4926799__F3 Summary of the mechanisms by which stress-related immune alterations may precipitate depression RORC UNK IL1B PMC11023972__F5 DDR components regulate JAK-STAT signaling pathways FEN1 STAT1 STAT2 BLM IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC10500222__F1 CELF2 affects ferroptosis through the MAPK signalling pathway ALOXE3 GPX4 FACL4 NFATC1 SLC7A11 WDR76 TFRC CELF2 ARF6 GLS PMC4573837__F1 Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors RICTOR EIF4E MTOR EIF4B PMC10500222__F2 CELF2 affects ferroptosis through the PI3K/AKT signalling pathway GPX4 FYN FTH1 SLC7A11 MT1G PTEN CELF2 EIF4EBP1 MTOR NQO1 PMC7892952__F1 Adenine-based purines are ubiquitous compounds present at intra- and intracellular levels in normal (i.e., astrocytes) and tumoral (i.e., GSCs) cells NTS PMC4748411__F4 Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model CPM ARRDC3 NR3C1 FOXP2 MT4 MAGEA4 HLA-DOA PMC7398916__F5 BCR Signaling Pathway with FCRL genes PIK3R1 PPP3CA MAPK8 LAT2 ATF2 PPP3CC GSK3B MYC CREB1 TEC PLCG2 E2F3 CRKL PDPK1 NCK1 DAPP1 FYN INPP5D RAPGEF1 HCLS1 VAV1 IMPACT PIP5K1C HRAS CRK FOXO1 CALM1 RPS6KA1 MAX GRB2 MEF2C CDC42 PLCG1 IKBKG CHUK BRAF CD81 MEF2D BTK BASH PTPN6 IRF4 JUN CD19 GSK3A RAC1 BLK CD79B CD79A CBL BCL6 IKBKB CARD11 NFKBIA NFATC2 RASGRP3 GAB2 NFKB1 LCK RELA CD22 LYN STM7 SYK FCRL5 RAF1 FCRL3 SOS1 REL PIP5K1A SHC1 PTPN18 VAV2 PMC3968564__F1 1A: Base excision repair (BER) pathway targets DNA damaged during replication or by environmental agents RAD51D XPC RAD52 ERCC1 XPA XRCC3 RAD51B RAD51C PMC6466823__F4 Main pathways and respective genes found in different treatments of ECs MYOF RAB14 CD9 GNB2 METAP2 CSTB PRKCA MCAM CKAP4 PTPN1 NPC2 PRKDC RAB11A LAMP2 STOM FGF2 CD44 ARHA ENG PROCR GRN HLA-B PTX3 GNG12 RAB10 HLA-A CD59 CANX RELA CTNND1 GNB1 HLA-DQA2 CDC42 HEL-S-43 PMC6376179__F4 Mutations in key pathways controlling cell growth IGF1R BRAF RUNX1T1 EGFR TBX3 PTEN RB1 CDKN2A CCND2 NF1 FGFR1 ATM CCND1 GATA3 MAP3K1 RUNX1 CDKN1B ERBB3 FGFR3 MAP2K2 RAC1 IKBKB TSC2 TSC1 JAK3 RAF1 AKT3 STAT3 PMC4677035__F6 FcGR-mediated phagocytosis pathway in the KEGG database is the putative pathway which is related to TNFA and TGFB1 expression in microglial cells VASP MARCKS GAB2 SYK LAT PMC10500222__F5 CELF2 affects ferroptosis via the Wnt/Beta-catenin pathway COX2 PAK1 GPX4 LRP6 CELF2 PMC10420029__F8 Transcription related pathways in the seminal tissues of P EIF5B NUP205 POM121 PAIP1 NUP188 CCNH TAF9 PUF60 NUP62 MAGOH RANBP2 AQR TAF12 THOC7 CDK7 CCDC12 TAF13 TAF11 THOC6 TAF15 CHERP TBP NUP93 TAF7 SNRNP27 NUP54 NUP85 SLU7 TAF3 NUP107 EIF4B TAF6 TAF4 ELF2 TAF10 ELF1 SUI1 NUP214 NMD3 NUP153 RAN OTP ELF4 RBM22 PHAX PMC10500222__F6 CELF2 is the upstream regulation factor of MAPK signalling pathway, PI3K/AKT signalling pathway, autophagy and ERAD pathway, which can promote cancer cell ferroptosis through these pathways NFATC1 PTEN CELF2 DKFZp686F0183 PREX2 PMC7994620__F4 Activation of cyclic AMP pathway through various genetic defects in adrenocortical tumors and hyperplasias PDE11A PRKAR1A PRKAR1B GNAS PMC10928970__F1 BRAF gene signaling pathway EGF HRG BRAF EGFR ARAF PMC3494542__F3 TGFB non-canonical signaling pathway ARHA RAC1 CDC42 PMC5547956__F6 Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease CD14 MOS DAO FLNA EGFR TRAF6 TNF NLK MAX GRB2 ECSIT TRAF2 JUN PMC5547956__F7 Synopsis of significant mitogen-activated protein kinase (MAPK) signaling pathway in the dentate gyrus (DG) of mice exposed to MPTP according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis CD14 EGF NGF FLNA EGFR TRAF6 TNF MAX GRB2 ECSIT BDNF TRAF2 JUN BAP1 PMC4319670__F1 Insulin signal transduction pathway PI3 PTEN IRS1 SNAP23 PMC6029073__F1 Schematic diagram of the Sho1-dependant branch of the yeast high osmolarity glycerol (HOG) pathway as a model system for analysis of short linear motif function in signal transduction NUP133 CDC42 PMC5260495__F8 A schematic diagram shows that CD9 binds to gp130 and stabilizes gp130 by blocking its ubiquitin-dependent lysosomal degradation to promote the BMX-mediated STAT3 activation in GSCs CD9 BMX GSC IL6 STAT3 PMC6029073__F7 Examples of well-characterized signaling pathways contain numerous predicted short linear motifs APC HEL-S-64p LRP5 LRP6 PMC10934027__F6 Metabolic pathway of terpene biosynthesis MVD MVK IPP MVP PMC5468443__F1 mTOR Signaling Pathway TSC1 PTEN IRS1 PDPK1 PMC6747043__F3 Endoplasmic reticulum (ER) stress-mediated inflammation ATF4 EIF2A TRAF2 XBP1 PMC8517779__F1 Biomarkers for gastrointestinal adverse events related to thiopurine therapy TPMT PACSIN2 NUDT15 PMC7552614__F10 Representation of the TGFB, BMP, and WNT signaling pathways SMAD4 MTOR PMC1409799__F4 MAPK signaling pathways RET MEA1 SELL OPA1 PMC3578480__F2 Molecular pathways associated with CPPs TWIST1 NOTCH3 PMC10572663__F2 Signaling pathways regulating EMT DHH EGF IHH SNAI1 HGF SMAD2 APC SMAD4 MTOR LEF1 TWIST1 SHH SMO JUN PMC2855202__F3 Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion VAMP2 OGA OGT GSK3B PTEN SP1 PMC10572663__F3 Hypothetical contribution of EMT-like process to the pathophysiology of RA MMP3 RUNX1 SMAD2 TES MMP9 MTOR PMC10572663__F4 Hypothetical contribution of EMT to the pathophysiology of pSS COL3A1 SMAD2 ZEB2 TES MMP9 COL1A2 TGFB1 PMC3847504__F5 Schematic illustration of the correlation in mechanisms among detected parameters HMGB1 TLR7 MYD88 TLR3 PMC9935518__F7 Decision-making workflow for selecting treatment for newly diagnosed ER+/HER2- metastatic breast cancer patients FOXO3A AEBP1 CDK4 MTOR CDK6 PMC11858609__F6 Illustrates the MAPK and NFKB signaling pathways activated by pro-inflammatory stimuli such as LPS, IL-1, IL-26, TNFA, and PAMPs COX2 TLR4 PMC11858609__F7 Effects of bioactive compounds on periodontal bone remodeling RUNX2 BMP2 NFATC1 PMC11858609__F3 Illustrates the NFKB signaling pathway, highlighting the role of pro-inflammatory stimuli such as LPS, IL-1, IL-36, TNFA, and PAMPs, which activate receptors (TLR4, IL-1R, TNFR) to initiate intracellular signaling cascades RIPK1 TLR4 TRADD IRAK1 IRAK2 TRAF6 MYD88 TRAF2 PMC4465296__F1 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer TIAM1 INA PC MDM2 ETV4 PMC4465296__F3 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer TGFBR1 TGFBR2 SHH PMC7246929__F1 Extrinsic apoptotic signaling pathway TRADD TNF TRAF2 FADD PMC7774640__F1 Cartoon proposed model of thyroid-associated ophthalmopathy (TAO) pathogenesis IGF1 CD34 CD40 PMC7471609__F3 Metabolic map visualization for (A) redox and hydrogenases pathway, (B) pyruvate node that links glycolysis, incomplete Krebs cycle, anapleurotic pathway, and fermentative pathway, and (C) sulfur metabolism using the Escher tool PPIE PPIH ME2 PC MALL POR FDXR PMC8143163__F1 Impact of H2S on Obesity-Associated Metabolic Disturbances CTH DAO pcap PMC5493710__F3 Improvement of the reprogramming process and replacement of c-Myc by small molecules and chemical compounds WNT3A TGFBR1 BMP4 PMC11626610__F4 Genes from the Toll-like receptor signalling pathway remain differentially expressed 8 h post 4th dose in MAD cohorts CD14 CTSK TLR9 IRF7 TRAF3 IRAK4 IRF3 RAC1 MYD88 TNF TLR1 TLR3 PDC TLR4 LBP CD40 FADD TIRAP PMC3077244__F5 The proposed signalling pathway PTEN PMC4092857__F3 Activation of the DNA damage response upon CDT exposure ATM CDK2 ATRIP CDK4 CDC2 ATR BAX PMC3876433__F1 Oxidative metabolism in cancer PIM1 VEGFC GAB2 SRC MCL1 STAT3 PMC5328987__F1 Type III IFN signaling pathway IFNL3 STAT2 IRF3 TYK2 IFNL4 SOCS1 IFNL2 IL10RB MX1 USP18 PMC6704952__F9 Proposed mechanisms involved in the increase of SMN expression induced by ERK inhibition in the spinal cord of severe SMA-like mice SMN1 PMC12174016__F2 Mechanism of therapeutic strategies targeting pyroptosis for AD MAF NLRP3 TLR4 TXNIP GSDMD PMC12174016__F1 Molecular mechanism of pyroptosis NLRP3 NLRC4 NLRP1 AIM2 PMC8712646__F1 Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention CXCR3 CXCL10 CXCL9 NOTCH1 IL2 JAK1 PMC9124774__F1 Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment TSC1 PTEN MTOR PMC7518314__F1 Overlap between immune-signaling genes that are associated with pollution and SCZ CD14 TLR4 CRP IRF3 PMC3828651__F2 Molecular events associated with tumor suppressor gene product-induced senescence or apoptotic cell death of tissue-resident stem/progenitor cells during chronological aging ATM MYC PTEN BAX PMC6562892__F2 PPAR (peroxisome proliferator-activated receptor) signaling pathway enriched of differentially expressed genes (DEGs) in the jejunum of broiler chickens UBC PLTP SLC27A4 ACADL UCP1 PCK1 HEL-S-28 LPL SLC27A1 CPT2 EHHADH CD36 PMC7554122__F3 TGFB2-Hepcidin feed-forward loop HAMP TGFBR1 TGFBR2 PMC8124305__F3 S-Nitrosylation in Tumor Microenvironment IL1A HGF MMP2 MMP9 CD48 CCND1 SRC TNF IFNG STAT3 PMC3193469__F4 Simplified cartoons illustrating the components of the cullin–RING E3 ligases (CRLs) CDC20 APC SKP1 APC2 RBX1 DDB1 PMC4355029__F4 RNA toxicity leads to activation of NFKB pathway BIRC2 RELB HEL-S-162eP PMC7376907__F1 Macroautophagy and mitophagy ATG101 UVRAG MTOR OPTN DKFZp686F0183 PMC5073094__F2 Stimuli for degranulation of mast cells and basophils and interplay/overlap with type II-IV reactions XPNPEP2 DAO ALOX5 LTC4S NAT2 ITCH PMC7376907__F2 NLRP3 and AIM2 inflammasome pathways NLRP3 AIM2 GSDMD PMC7404091__F1 This figure summarizes the regulatory core of ferroptosis, approximately divided into three axes GPX4 LPCAT3 ASCL4 KEAP1 ALOX15 DKFZp686F0183 TF PMC3193469__F6 Model of GA-induced DELLA protein degradation and the regulation of PIF protein function SKP1 RBX1 PMC3237253__F3 Adhesion of sickle red blood cells to the endothelium and cell activation CD47 BCAM VCAM1 CD44 CD36 PMC11576158__F2 Is choline kinase alpha a drug target for obesity? PRDM16 UCP1 PPARG NR1C1 SIRT1 PMC6930181__F2 Metabolic features of healthy and dysfunctional endothelial cells ME2 ARG2 MDH2 FASN HEL-S-162eP GLS PMC9149409__F7 Long Noncoding RNA MEG3-205/Let-7a/MyD88 Axis Promotes Renal Inflammation and Fibrosis in Diabetic Nephropathy AGO2 IL13 MYD88 PMC6155137__F8 GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway RHO RAC1 CDC42 PMC1698952__F4 Aspects of PRLR signaling as related to mammary gland function PRLR GRB2 TEC SRC IRS1 PRL PMC6836431__F1 mTORC1 and its signaling networks NOTCH2 NOTCH4 ULK1 GSK3B PTEN HIF1A MTOR DEPTOR NOTCH3 RHEB MLST8 TSC2 TTI1 TSC1 ATF4 NOTCH1 GRB10 PMC10451996__F12 Mechanism by which fibroblast upregulation of VDR suppresses lung fibroblast proliferation and activation during pulmonary fibrosis NR1i1 JAK1 STAT3 PMC5655592__F6 Genes affected concordantly within the ileum and meta-analysis data sets formed biofunctional clusters of overlapping pathways CCR5 CTLA4 PMC5655592__F3 The antigen presentation pathway was downregulated in the GF mice TAP2 HEL-S-269 PSMA4 ALB PSMB2 HEL-S-99n PSMA2 PSMB3 PSMB10 CDC42 PMC5655592__F4 Intraset concordancy and transcriptome-proteome discordancy of gene products related to protein translation, OxP, and chaperone proteins HSP90AB1 HSPA2 TRIM21 RPL27 HEL-S-310 RPL4 RPL30 EIF4E DNAJC2 RPSA RPS16 ZNRF4 RPL39 RPS10 RPL17 CANX COX2 RPS13 PLAT REL SDHD RPS12 SDHB PMC5715866__F6 Schematic showing the roles of EGFR ligands and NRG1 in the regulation of timing of ovulation and oocyte maturation EREG BTC AREG ERBB3 EGFR NRG1 PMC5779007__F7 HIF‐1A strongly associates with differentially expressed genes in rAAA VEGFC ANGPTL4 HAMP BMP2 FOS TNFAIP2 NTRK2 HEL-S-130P HILPDA APOE CITED2 PMC8616463__F3 Global Reprogramming of Apoptosis-Related Genes during Brain Development TRADD ATM CAST POR CAD REL TNF FADD BAX PMC8643334__F1 Hepatitis B Virus e Antigen and Viral Persistence TNF IL1B PMC9018988__F1 Molecular Network of Colorectal Cancer and Current Therapeutic Options BRAF APC SMAD4 CDKN2A PMC5039366__F5 Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells APC GSK3B RYK HEL113 PMC7106732__F2 Histone chaperone landscape of breast cancer metastasis PI3 ANP32E NPM1 FOXA1 DEK HJURP SKP2 CCNE1 PMC3172097__F1 Autophagy pathway in plants ATG12 ATG10 ATG14 PMC7318302__F1 Correlation of Notch signaling pathway and ER in breast cancer endocrine resistance MCAM HBD EGFR PMC8817240__F7 Sam68 contributes to intestinal inflammation in experimental and human colitis CCR2 CXCL10 RELA TNF CSF2 PMC7554194__F2 Other signals that regulate Schwann cell development P2RY1 P2RY2 ADAM22 P2RX7 APC ARHA LPA GPR49 CDH2 LGR6 PMC7554194__F3 Schwann cells integrate signals from the extracellular matrix (ECM) including mechanical forces, laminins and collagens DAG1 EGR2 YAP1 ITGA6 GNAS PMP22 PMC3799862__F5 Role of TRAF6 in RANK Signal Transduction Pathway TRAF5 NFATC1 TRAF3 TRAF6 MTOR MAP3K7IP1 TRAF2 TAB3 PMC6375727__F7 eIF2BE Constitutes a Pivotal Node between the Responses to Canonical Stress and Sema3ASema3A induces an initial (5 min) wave of local translation independent of the eIF2 pathway mediated by ERK-1/2 and mTOR ELF2 SEMA3A EIF2B1 GSK3B MTOR PMC4848607__F1 KEGG pathway analysis for the Toll like receptor (TLR) signaling pathway differentially expressed genes (DEGs) expressed in response to SAV-3 infection in TO-cells CD14 CTSK TLR9 IRF7 CD6 TRAF3 TRAF6 IRAK4 IL6 TNF TLR3 CPO LBP CD40 MPL FADD TIRAP PMC9040670__F8 Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens ATF4 ASNS EIF2A FGF19 PMC3573143__F2 Regulation of autophagy in response to stress TSC2 TSC1 ATG12 ATF4 EIF2A PTEN BNIP3 MTOR RHEB PMC4848607__F2 Summary of the Toll like receptors (TLR) and RIG-I like receptor (RLR) pathway genes based on upregulated genes shown in and excluding the downregulated genes shown in and IRF7 TRIM15 IRF3 PMC6700252__F3 Intrinsic intracellular signaling cascades of BDNF-TrkB and TrkB-A2a receptors PI3 GRB2 BDNF PMC5729535__F1 Extrinsic and intrinsic apoptotic pathways APAF1 FADD BAX PMC8427766__F3 COVID-19 Immunobiology: Lessons Learned, New Questions Arise CD14 STAT2 IRAK1 IRF9 TRAF3 TRAF6 IRAK4 IRF3 IL6 CCL2 MYD88 TNF MAP3K7IP1 STAT1 TLR8 TLR7 TLR4 TYK2 CD80 JAK1 TIRAP MAVS TAB3 PMC7457511__F9 Network analysis of DCAF subfamily genes GNB2 GSK3B DTL SIN3A PHIP BRWD1 PDHA2 AMBRA1 DDB2 DDB1 CUL4A FBXW8 RBBP7 DET1 RPL10L ABCC11 FBXO22 PWP1 DCAF7 DDA1 DCAF15 DCAF1 TLE2 LSM12 CRBN CSN1S1 TLE3 WSB2 BTRC ENTPD6 GRWD1 ACRV1 HCN3 WDR26 RNMT DCAF12L2 DCAF12L1 TOR1AIP2 HDAC5 KATNB1 WDR22 DCAF16 DCAF17 KATNA1 DCAF10 DCAF12 CCDC71 DCAF13 WDR59 CENPW DNAJC16 WDR57 NLE1 SMU1 WDR5B RNF220 ITLN1 WDR12 RFWD2 EED WDR76 AFMID PMC8427766__F4 COVID-19 Immunobiology: Lessons Learned, New Questions Arise TBK1 STAT1 STAT2 IRF9 TRAF3 IRF3 JAK1 MAVS PMC10453169__F5 Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma SHH SMO PMC4305100__F3 Interaction of HBV and TLR2/4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC6275186__F2 Representative image of the participation of SARA in the TGFB signaling pathway EEA1 PPIC PMC10453169__F2 Schematic model of the canonical HH signaling pathway DHH IHH SUFU SHH SMO PMC4645345__F9 Proposed mechanism for SCG2 expression in HSV- and reovirus-infected cells SCG2 ARHA RHO PMC9454399__F5 Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification ICE1 LCK GDA MIA PTEN LAT TIRAP POLI BATF PMC7923165__F2 B-cell receptor signaling pathway is enriched in SYK targets in the DG75 Burkitt lymphoma cell line BTK CD72 BCL10 BCR RASGRP3 BASH GC CD22 LYN GRB2 SYK CD19 PMC7264416__F4 Protein–protein interaction (PPI) network and pathway involving the survival-associated features TH CD14 PDE3B SET HEXA GEM UCN HEL-S-99n FGFR3 IRAK4 LEP PATJ GRB2 LBP CCND1 C13orf34 LAT PCNA HEL-S-81p TIRAP GABARAP PMC7923165__F3 Actin cytoskeleton regulation pathway is enriched in SYK targets in the MCF7 and MDA231 breast cancer cell lines F2 APC INS DOCK1 RHO HEL114 PXN PMC8979960__F7 Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease SGMS1 SPTLC2 SMPD1 SPHK2 CERS2 PMC2587278__F1 Oxidative and alkylation DNA damage is effectively repaired by the DNA BER pathway EGR1 HIF1A TG OGG1 MPG NEIL1 HLF PMC5650494__F3 Immune mediators in the brain and peripheral tissues in autism spectrum disorder TSC2 TSC1 PTEN EIF4E RHEB PCDH10 PMC8418145__F2 Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases PINK1 TFEB CD40 PMC5368188__F5 LIN28A/ZCCHC11 regulation of let-7 microRNA biogenesis, promoting cellular proliferation and modifying bioenergetics LIN28B PIK3IP1 CCNA2 ATPAF1 CS CRY2 MYC LIN28A CCND3 IGF2BP2 CDK6 TK1 INSR CCND2 AK2 HMGA2 RICTOR TSC1 DHFR CCNB1 PAICS CCND1 HK2 PMC5368188__F6 Transcriptional networks that regulate LIN28B expression LIN28B SIRT6 MYC REST PMC8408558__AF1 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway DKK3 GSK3B LRP6 SFRP1 DKK2 TCF4 PMC9381797__F1 Insulin signaling pathway was found to be associated with cerebrovascular pathologies in AD including inflammation, BBB disruption, and AB accumulation VCAM1 PGP GSK3B GRB2 PTEN PMC4830430__F4 Functional interplay between PPM1G and the transcription elongation machinery MEPCE LARP7 ATM PPM1G CDK9 PMC11688061__F7 Jak-STAT signaling pathway and related target expression, such as STAT DAO IRF9 GFAP VHL TFRC PFKL HEL-S-87p MTOR RBX1 HEL-S-162eP TLR4 TYK2 JAK1 HEL-S-133P TF PMC7880745__F7 Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells GRB2 ARHA JUN PMC4868719__F7 Notch and Wnt/Beta-catenin signaling pathway play important roles in activating liver cancer stem cells WNT3A APC CCND1 HES1 PMC7537138__F4 SARS‐CoV‐2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors UNK SRC ACE2 PMC6472151__F1 The effects of thyroid hormones on the activity and expression level of eNOS in vascular endothelial cells PI3 PMC3251651__F4 Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy SUV39H1 DHFR MDM2 SIN3A PCNA PMC5897396__F7 The proposed PTN pro-migratory signaling pathway that leads to CDK5 activation in human endothelial cells PTN CDK5 RAC1 PMC7884184__F2 The Keap1-Nrf2 signalling pathway in antioxidative stress-related radio- and chemoresistance TFEB KEAP1 TXN PMC7884184__F3 (1) The role of the PI3K-AKT signalling pathway in antioxidative stress related to radio- and chemoresistance TSC2 PTEN RHEB PMC9702353__F8 Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NFKB/NLRP3 signaling pathway NLRP3 TNF GSDMD PMC3249608__F2 RA-dependent non-transcriptional involvement in neurite outgrowth BAD PDK2 PTEN RAC1 MTOR BAX PMC5632457__F1 Predicted target genes of miRNA-34a in renal cell carcinoma pathway [KEGG hsa05211] HGF SOS2 VEGFA VHL PAK4 CRK CREBBP EGLN3 EP300 PTPN11 GRB2 TGFA JUN ARAF PMC3753703__F3 Alterations within the TP53 and RB1/E2F3 pathways in high-grade bladder cancer MDM2 CCND1 RB1 E2F3 CCNE1 PMC8025646__F1 Signals and molecules of pathological phagocytosis between microglia and target cell HEL-S-62p SIRPA CD47 MERTK PMC8301007__F8 Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1Alpha-Sirt1 Pathway SIRT1 PMC6511634__F8 Schematic illustration for the potential mechanisms of PC4 in AIPC progression CDK6 PMC9280721__F1 MTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation TSC2 TTI1 TSC1 MTOR DEPTOR SGK1 MLST8 PMC11529026__F2 Smad-dependent and Smad-independent TGFB signaling in EndoMT SMAD2 TGFBR1 TGFBR2 SMAD4 CDH2 PMC4495377__F5 The flow of glucose carbons in the presence of added fructose in adipocytes MTHFD2L NNT MTHFD1 HEL-S-51e MTHFD2 PMC5578007__F2 Notch signaling modulates endothelial cells’ (EC) fate associated with neointimal hyperplasia NOTCH4 NOTCH1 PMC4147035__F1 NFKB: A Coordinator for Epigenetic Regulation by MLL HOXA9 RELA MEIS1 DOT1L PMC6469758__F7 TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro TLR4 IRF3 MYD88 IL1B PMC7753765__F3 Viruses join the circular RNA world TRIM59 TLR3 PMC3408195__F9 A novel KRAS-initiated pathway leading to the activation of VMP1 in cancer cells GLI3 VMP1 PMC5392402__F1 The workflow of PAIRS INA SET PTEN PMC3749885__F2 Pim kinase targets and their roles in inflammation and cancer BAD SOCS3 ELF4 SOCS1 PMC7016599__F2 Some of the signaling pathways regulated by integrin A6B4 in colorectal cancer cells ITGB4 MAX APC BIN1 GSK3B MYC PMC8392871__F5 Novel Polyethylene Glycol-Conjugated Triazole Derivative with High Thyrointegrin AvB3 Affinity in Acute Myeloid Leukemia Management MMP10 LIF MPC1 SRC PMC8698607__F6 Comparative Proteomic Analysis of tPVAT during Ang II Infusion UCP1 MTOR STAT3 PMC6639052__F2 Proposed role of NEDD4 in IGF-1R signaling IGF1R IGF1 PTEN GRB10 IRS1 NEDD4 PMC5558474__F3 Impact of glucocorticoid on neurogenesis SMO DKK1 SGK1 PMC8839902__F1 Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis RUNX2 SMAD2 MSC PTH SMAD1 DKFZp781O1323 PMC7929780__F7 Canonical Notch signaling with points of intervention of current therapies ADAM10 ADAM17 PMC2474948__F1 Integration of the TGFB1 apoptotic signal by the lipid oxidation end-product 4-hydroxynonenal ATF2 SMAD4 TGFB1 PMC8703169__F3 Mitophagy in Diabetic Kidney Disease TFEB BNIP3 SKP2 SIRT3 PMC8586418__F1 Recent Progress in Interferon Therapy for Myeloid Malignancies TBK1 STAT1 CGAS STAT2 IRF7 IRF9 IRF3 TYK2 JAK1 TNF TRAF2 PMC8703169__F1 Mitophagy in Diabetic Kidney Disease UBR1 UBR4 VCP PARL PMC2916219__F5 A model for regulation pathways responsible for RN and AM symbioses MYC NUP85 PMC11979243__F3 Exosomes from different mesenchymal stem cells mediate apoptosis in brain cells after cerebral ischemia-reperfusion injury DAPK2 MTOR USP22 AIM2 SIRT1 FOXO1 PMC12149175__F0 Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway PIK3R1 EGFR PTEN MTOR PMC11988641__F1 MMP13 orchestrates dynamic remodelling of the extracellular matrix (ECM)’s physical properties MMP9 EGFR PMC11520424__F3 STAT3 in HER2-positive breast cancer EGF SRC STAT3 PMC2901871__F7 Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis GEMIN6 GEMIN7 GEMIN8 GEMIN2 GEMIN5 PHAX PMC8795506__F9 Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells TLR4 SOCS3 MYD88 IL1B STAT3 PMC8988049__F7 Proteome-Level Investigation Into Plasmodiophora brassicae Resistance in Brassica napus Canola MYB MYC ERF PMC11520424__F2 Main STAT3 signal transduction pathways in breast cancer PTPRT IL21R EGF SOCS3 EGFR ERAS MTOR OSMR PTPRC PIM1 CNTFR GHR IL7R SRC TRIM28 DUSP2 TF STAT3 PMC10536292__F9 Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells PCSK9 GSK3B LDLR GCK FOXO1 HMGCR FASN PMC10759256__F1 DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells GCLM GCLC HEL-S-64p PMC6624737__F1 Simplified demonstration of decarboxylation events with associated position-specific isotopomers used in this study HEL-S-62p PC PMC7546399__F9 Network diagram of the metabolic pathways regulated by XFZYD on d 3 and 21 GAD2 GABRA2 ARG1 GAD1 PMC4832872__F3 Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E2 and Toll‐like receptor/MyD88 pathways CD14 HMGB1 CD133 SOX2 CD44 MYD88 STAT3 CCL3 PMC7082326__F1 Mitochondrial PTEN-succinate axis promotes P NLRP3 TLR4 NLRC4 PTEN IL1B CFTR PMC7333287__F9 PI3K-Akt signaling pathway influenced by XLGB EGF BAD CDK2 EGFR GSK3B MYC MDM2 GRB2 BCL2 RHEB RXRA PMC9667311__F2 Ultrahigh resolution MS1/MS2-based reconstruction of metabolic networks in mammalian cells reveals changes for selenite and arsenite action TH SPOP HEL107 PMC3868569__F10 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans PMC3804348__F1 Regulation of lipid metabolism in glioblastoma and the therapeutic drug targets IDO1 LDLR ABCA1 MTOR PMC6751266__F1 Overview of microRNA-27a biogenesis, highlighting key enzymes in miRNA biogenesis DGCR8 DROSHA XPO5 PMC6751266__F2 Brief conclusion of miR-27a in regulating cell signal pathways Panel gray, miR-27a can regulate Ras/MAPK/ERK pathway to active key gene such as c-myc EGF PHLPP2 SMAD2 GSK3B SMAD6 SMAD4 FBXW7 FOXO1 PMC6896744__F1 Schematic overview of the WNT signaling pathway TIAM1 MMP3 MMP7 APC LRP5 LRP6 ADAM10 PMC6466116__F5 Transcriptomic analysis of Fgf10+/− versus control P3 lungs in NOX suggests that reduced Fgf10 expression could lead to vascular defects EDNRA BAD RAC3 OMP MAP2 NPR2 DAO ROCK1 FGF10 MAPK1 GNAS HRAS PMC7533107__F1 TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation NLRP3 TLR4 CXCL8 TRPM2 IL1B GSDMD PMC6109817__F2 Cross-talk between oestrogen (ER) and epidermal growth factor receptor (EGFR)/insulin-like growth factor 1 receptor (IGF-1R) signalling pathway and cyclin-dependent kinase (CDK)4/6 function IGF1R CDK4 MTOR PMC5490640__F4 Ubiquitin enzymes in the regulation of T cell-mediated autoimmunity STUB1 CYLD RELA ZAP70 AIRE ICOS SKP2 ITCH FOXP3 PMC5490640__F5 Ubiquitination in B cell activation OTUD7B TRAF3 TRAF6 CD40 TRAF2 PMC6975291__F11 The proposed pathway for suppression of glutamate release by postsynaptic metabotropic NMDAR signaling to Panx1 HEL-S-11 SRC FAAH PANX1 TRPV1 PMC5490640__F6 Ubiquitin chains and ubiquitin enzymes in the TNF-induced NFKB and apoptosis pathways RIPK1 TRADD CYLD RELA SHARPIN TNF OTULIN TRAF2 FADD PMC5490640__F7 TRIMs in the regulation of the immune response TRIM56 TRIM6 TRIM25 TRIM65 PMC5490640__F3 Ubiquitin enzymes in the TCR signaling pathway PLCG1 USP15 OTUD7B PELI1 MAP3K7IP1 USP18 BCL10 PC CYLD RELA LCK USP9X ZAP70 MDM2 MIB2 ITCH PMC9581404__F3 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases APC LRP5 LRP6 PMC2895421__F2 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway IKBKB TSC2 SOCS2 TSC1 PIK3CA IL6 PTEN IL4 TNF MTOR SOCS1 PMC9581404__F2 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases APC PMC5458740__F1 ECM–cell communication is dictated by focal-adhesion players GSK3B SRC MTOR PMC5604037__F6 Schematic overview of MYC-mediated metabolic pathways PFAS OMP PFKM MTHFD2 MTR ADSL DHFR TYMS PAICS RPIA CAD DHODH MME HEL-S-281 PMC5016689__F7 Proposed model for the impact of CCL2 on HDL internalization and cholesterol efflux and regulatory mechanisms in HCAECs CCR5 CCR2 CCR3 CCL2 PMC10376673__F1 Breaking Bad: Inflammasome Activation by Respiratory Viruses NLRP3 CGAS GSDMD PMC2668236__F2 Major pathway and inflammatory mediators of sepsis and its related conditions CD14 VCAM1 IRF3 TNF TF PMC10489316__F9 Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway BAD DAO GRB2 SHOC2 RHO RAC1 LAT CDC42 MAL PMC5009769__F1 Wnt pathway regulation of intestinal stem cells APC GSK3B LRP5 CD44 CCND1 LRP6 DKK1 WIF1 PMC7509716__F1 Proposed mechanism for enhancing antigen‐specific immune response by the CS‐IONzyme‐based influenza vaccine IL16 CD40 CD80 JUN PMC5009769__F3 Wnt pathway regulation of intestinal stem cells ZNRF3 RNF43 LRP5 LRP6 GPR49 LGR6 PMC6232757__F1 Representative scheme of the presence of O-GlcNAcylation on glucose metabolism in skeletal muscle OGA OGT FH IRS1 HEL-S-162eP PMC5335506__F2A Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage ABCD3 MYL6B KEAP1 TPR HEL-S-108 DSG2 PGAM1 CD2AP NAMPT SRP14 LBR NONO AAAS SPTA1 BTAF1 EIF3C PSMD3 FLOT2 EED ADAR PSMF1 EMD CPSF3 EIF3F ADA PMC7011400__F5 Proposed model for the effects of BSZYD on HEMEC angiogenesis through the VEGFR-2-mediated regulation of the MAPK signaling pathway MMP9 CCND1 PCNA PMC10910758__F7 Therapeutics of endochondral ossification and FOP targeting NFKB signalling HMGB1 TLR4 ACVR1 RUNX2 MSC RELA ID1 SMAD1 SIRT1 DKFZp781O1323 SOX9 SMAD9 PMC10878139__F5 TGFB signaling pathway mediates the effect of the GR signaling pathway in the TM SMAD2 SMAD4 PMC10878139__F3 Cross-talk between glucocorticoid receptor and YAP/TAZ signaling pathways LATS1 LATS2 PMC10878139__F4 Cross-talk between glucocorticoid receptor and Wnt signaling pathways APC SFRP1 ARHA ROR2 RAC1 DKK1 AXIN2 PMC11201249__F2 Schematic presentation of mTOR modulation pathways TSC2 NPRL2 TSC1 C16orf35 DEPDC5 MTOR PMC3974856__F2 Tolerogenic plasmacytoid DC PDC TLR9 CCR6 VCAM1 CXCR4 PMC10910758__F1 Simplified diagram of the canonical pathway and alternative pathway of the NFKB signalling pathway (Created with BioRender TLR4 LTB RELB CD40 TNF PMC2533023__F5 Response of A549 cells exposed to crocidolite SOCS2 SOCS3 TNFRSF12A IRAK2 MYC STX1A CXCL3 MAP2K6 LIMA1 SMARCA4 LYST ADM PLAUR ING1 ATF3 GADD45A RGS2 TNF LHB PTHLH FOXD1 VEGFC KLF4 BTG1 SPHK1 HSPA1A TNFAIP3 RUNX2 GEM IL11 PTEN BCL2L11 LATS2 THRA CITED2 PPP1R15A FST RARA GADD45B GREM1 AHR GDF15 BIRC3 STC2 KLF6 PTGS2 NTRK3 CXCL2 IL6 DDIT3 BCL6 PIM3 VGF TRIB1 HLTF TFAP2C TIPARP STX3A TNFRSF10B HRK PMC10910758__F4 NFKB signalling during chondrogenesis in endochondral ossification IGF1 RUNX2 BMP2 MSC BMP7 RAC1 SOX9 BMP4 PMC10910758__F6 Scheme of FOP pathogenesis and the involvement of NFKB signalling HMGB1 ACVR1 RUNX2 SMAD4 LPA MTOR ID1 SOX9 SMAD9 TLR4 ENPP2 MSC SMAD1 DKFZp781O1323 PMC8454549__F3 Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse CRABP2 PITX2 SHH TRPM2 FSHR CYBB KRT18 COL4A2 CYP7A1 COL4A1 PMC7816290__F7 PPI network and Path-Act-Network analyses NUF2 KNTC2 SI TTK SMC3 NCAPG CENPE CDC2 CENPU SMC4 KIF11 PMC6540047__F6 BRO priming of NFkB target gene expression in the absence of virus CCL5 NFKBIZ CCL2 TAP2 GBP2 NOS2 CSF2 PSMB9 IRF-1 NAMPT EGR1 RSAD2 IRF7 BMP2 LIF CXCL10 CXCL2 CCL4 IFNB1 IL6 TNF CD69 IL15 HLA-A NFKBIA ERAP1 SDC4 VCAM1 TNFSF10 CXCL9 CD40 IL15RA TNFAIP3 TFEC PMC6540047__F4 BRO modulation of RV-induced NFkB target gene expression NFKBIA NAMPT NFKBIZ TFEC PMC6540047__F5 BRO priming of interferon response pathway in the absence of virus TBK1 ISG15 PIN1 RIPK1 IRF9 IFNE TRAF3 IRF3 FADD MAVS GYPB PMC7583882__F1 Schematic summary of Sphingosine 1 Phosphate (S1P)/S1PR (G-protein-coupled receptor) agonist and antagonist signalling SPHK1 RHO SPHK2 PMC8615162__F2 Coenzyme Q at the Hinge of Health and Metabolic Diseases MFN1 MPV17 PDZD8 BRAF FXN POLG HMGCR MFN2 LDLR SUCLA2 DHODH PARL ANO10 PMC5958474__F8 Oxygen sensors, VEGF pathway regulators and stem cell master regulators regulate DNA damage response gene expression in human tissues KIT SOX2 FLT4 CD34 VEGFA MYC HIF1A VEGFC FLT1 KDR KLF4 POU5F1 VEGFB PMC2810142__F9 Network diagram of Sp1-interacting proteins BRCA2 RAD51 CDK4 RB1 SP1 SKP2 STAT3 PMC8850363__F1 Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis? USP19 CXCL12 HIF1A APOE PMC7591658__F6 BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes BAG3 BAG6 HSPB8 VCP PMC5953448__F2 Breast cancer related pathways RNF31 RBCK1 SHARPIN PMC4778564__F3 Hepatitis C Virus and Autophagy ATG12 IRGM DKFZp686F0183 PMC4778564__F4 Hepatitis C Virus and Autophagy ATG12 DKFZp686F0183 MAVS PMC8721920__F1 Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development IFIT3 TBK1 CGAS IFIT2 TANK MYD88 CD74 USP18 STAT1 TLR8 CH25H OAS1 LY6E OAS2 TLR7 STAT2 IRF7 IRF9 BST2 IRF3 IFNAR2 IFNAR1 TYK2 JAK1 MAVS IFIT1 PMC9485831__F4 Biochemical and physiological insights into TRH receptor-mediated signaling BRAF TRH GSK3B GRB2 SRC ADRBK1 PMC6020372__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC KDM5B SFN ARHA PMC9576167__F1 Platelets and tyrosine kinase inhibitors: clinical features, mechanisms of action, and effects on physiology BTK FYN COX1 LYN TEC SYK PLCG2 LAT PMC5362544__F1 The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets ATP7B ATP7A ATOX1 PMC3552512__F3 Oncogenic signals regulate each stage of translation RICTOR EEF2 MYC EIF4E MTOR POLI PMC11077368__F11 Schematic diagram explains the mechanism underlying by which SP protects against colitis CGAS GPX4 FACL4 SLC7A11 CXCL10 PMC6265312__F1 Triggering receptor expressed on myeloid cells-2 (TREM2) in microglial survival and metabolism IL16 PC GSK3B CCND1 SYK ADAM10 MTOR IL1B APOE GSDMD PMC8775565__F6 Physiological implications and importance of both simple-type and composite-type GSKIP in Wnt signaling GSKIP PMC3389182__F1 Transcriptome analysis of HeLa cells response to Brucella melitensis infection: A molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis IKBKG CHUK BRAF MAP2K4 RASGRF2 EGFR RPS6KA4 MYC MARK4 MARK1 RAPGEF4 DUSP14 MAP4K3 JUN GADD45G MOS SOS2 NTRK1 GADD45A MAP3K10 MAP3K12 CRK DDIT3 CASP3 MAP2K1 MAX STK4 GRB2 PLA2G5 HEL-S-93 PMC5206486__F1 Domain structure of retinoic acid-inducible gene-I (RIG-I) IRF7 TRAF3 TRAF6 IRF3 TYK2 JAK1 IFNAR1 MAVS PMC8497755__F1 Metabolic Modifications, Inflammation, and Cancer Immunotherapy EGF EGFR B3GNT3 ZDHHC3 PMC8497755__F2 Metabolic Modifications, Inflammation, and Cancer Immunotherapy TLR4 IRF3 MYD88 ZDHHC6 NOD2 ZDHHC11 STAT3 PMC8557192__F1 New biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics LCK ZAP70 CDK5 HEL-S-92n CD80 PTEN JAK1 PMC3856107__F3 Roles and signaling pathways of let-7 in hypoxia- and neural stem/progenitor cells (NSPCs)-induced angiogenesis AGO1 SMAD2 PMC5883109__F9 EH regulates PGN-induced inflammatory response in DCs IRAK2 GSK3B TRAF6 IRAK4 MYD88 TIRAP PMC7486640__F5 One of the possible mechanisms of MFSD to alleviate the damage of high glucose to podocytes LRP5 LRP6 TCF4 PMC3836362__F6 Interaction between dietary protein and mechanical loading on skeletal muscle cell EEF2 RPS6 MTOR PMC7912811__F1 Gonadotropin releasing hormone (GnRH) receptor signal transduction in endometrial cancer (EC) EGF FOS EGFR GRB2 SRC JUND PMC11521822__F6 The angiogenic signaling pathway in lean vs ADIPOR1 ADIPOR2 TWIST1 PMC5571156__F7 Mechanism of QE action SMAD2 SMAD4 PMC7912811__F2 Signal transduction of the putative truncated GnRH-II receptor in endometrial cancer (EC) EGF EGFR JUND PMC7576257__F1 TRAIL signalling pathway TRADD TRAF2 FADD BAX PMC7054750__F1 Active integrin internalization and trafficking pathways RAB21 PGC RRAS PTPRF RAB11B PMC4383231__F1 Intracellular fatty acid metabolism HMFN0839 GPAT4 GPAT2 LPL LPA CD36 PMC3097115__F5 PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans CPSF6 BUD31 PUF60 KIN SF3A1 PPWD1 TFIP11 HTATSF1 LSM5 SART1 LSM7 RNF113A ZMAT2 SF1 SYF2 CACTIN RBMX2 U2AF2 RNPS1 SNRPA1 RBM22 SNRPB2 PMC4037811__F1 An Inside View: VEGF Receptor Trafficking and Signaling CD47 NRP1 SRC PMC8220148__F7 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer BAD FOS BIK CDK4 ERF JUN BAX PMC8220148__F5 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer DAO ALK CA14 MAPK14 PRKCA FGFR1 KDR NR1i1 MMP2 SREBF2 SRC CHRM2 BCHE NOS2 CA4 CA7 AURKC NR1H2 CTSL PTK6 SHE IL8RB HMGCR RET NR1C2 RORA CA12 TGFB1 PTGER2 NR3A2 PGR TGFBR1 EGFR NOX4 ACHE MTOR KIF11 BTK PTPN1 CDC2 NR1H3 RORC KIT CXCR1 ACVR1 MMP9 NR3C1 PTGES TNKS AURKA TNKS2 ADORA2A MAP2K1 PIK3CA TYMS JAK3 MCL1 FLT3 PMC3737722__F7 Model of cell-surface regulation of HH signaling BOC CDON PTCH2 PTCH1 SMO GAS1 PMC3718318__F16 ROS in endoplasmic reticulum (ER) stress-induced cell death LPA CD36 PMC4179633__F7 Lcn2 role as a negative regulator in NFKB-STAT3 loop activation in macrophages TLR4 LCN2 STAT3 PMC7210384__F1 MGP Promotes Colon Cancer Proliferation by Activating the NFKB Pathway through Upregulation of the Calcium Signaling Pathway MGP NFATC1 VEGFA PMC3228218__F1 HCG/MET signaling pathway BAD HGF GRB2 RAC1 CRK CDK6 CDC42 PMC8297977__F6 Transcription Factors and Methylation Drive Prognostic miRNA Dysregulation in Hepatocellular Carcinoma BAD NPY1R RFX5 FOXM1 RASGRF2 FOXO1 MMP14 ACAT1 CYP3A4 CXCR4 SRC CDC2 SGK1 PMC9686558__F3 Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review KEAP1 RBX1 PMC7814560__F6 Possible mechanism of Sfrp1-attenuated AMI injury in aged mice SFRP1 DVL1 PMC10950953__F4 Immune cells interacted with jaw stem cells by signaling pathways SAMD3 RUNX2 SUFU PIEZO1 SMAD2 APC MSC SMO DLX5 TNF PMC10950953__F5 Cellular interaction of immune cells and stem cells in the jaw MSC IL22 CCL2 PMC6258005__F3 Mitochondrial Fatty Acid Synthesis is the puppet master of mitochondrial biogenesis NDUFB9 NDUFA6 FMC1 FES HEL-S-5 PMC5844827__F1 Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment FCER1A CCL28 GATA3 PMC9650488__F6 Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking RELA AIDA TRO POR JUN MVP TGFBI BAX PMC3772117__F2 Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway PRC1 CSK PMC5397988__F2 Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy BAX PMC6309266__F3 Long (lncRNA) and short (miRNA) of it: TGFBeta-mediated Control of RNA-binding Proteins and non-coding RNAs SMAD2 TGFBR1 SMAD4 MSH2 TGFB1 PMC10530375__F3 Anti-Inflammatory Effects of Peripheral Dopamine WNT3A GSK3B PMC8318647__F1 Therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury APC LRP5 LRP6 BCL9 PMC11813745__F1 Figure-Schematic illustration depicting the role of Phosphodiesterases in Endocrine system and associated diseases CXCL10 CXCL8 CNP NACA2 ACE2 PMC3020905__F6 Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line ATF4 FTL UBB PMC3149315__F1 Biosynthetic pathway of GSL and the CIRES procedure A4GALT B3GNT5 B4GALNT4 GAL B3GALT4 ST3GAL5 PMC7523373__F1 Structure of Bruton’s tyrosine kinase (BTK) and associated cross-linking signaling pathways TH BTK BCR BASH LYN SYK PMC6092430__F1 The mismatch repair pathway MSH6 MSH3 MSH2 PCNA PMS2 PMC9027630__F2 Osteopontin in Microglia Biology: Current Concepts and Future Perspectives CD44 RAC1 CDC42 PMC7461113__F1 Notch signaling pathway FURIN MTOR PMC4973429__F2 Involvement of AKR1B1 in pathophysiology AKR1B1 PMC10854592__F2 STAT3 signaling pathway: STAT3 activation is initiated by upstream activity including ligand binding by (a) cytokines (IL-6 and non-IL-6 family members), (b) growth factors (EGF, FGF, etc c-fgr TWIST1 EGFR CCND1 SRC ARHA STAT3 PMC7821787__F1 MTOR signaling pathway and Rapalog therapeutic mechanisms TSC2 RICTOR TSC1 PTEN MTOR DEPTOR RHEB PMC3875765__F7 Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway PDGFD PMC5722815__F6 BMP2 or BMP6 signaling enhances adipocyte function LEP GIG8 ID4 SMAD6 SMAD4 ID1 PPARG SMAD1 ID3 DKFZp781O1323 RXRA FASN PMC9451491__F4 Yuan-Zhi decoction in the treatment of Alzheimer’s disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation SNCA MPO GSK3B VEGFA IL8RB KCNA2 LTB4R GLRB RET IL18 APP GRIN2B VCP IL4 MME PMC7425726__F9 Proposed regulatory pathway for FGF2 mediated mesenchymal transition in human corneal endothelial cells FGF2 HEL113 SP1 SP3 PMC3312242__F1 Regulation of cancer stem cells by inflammatory cytokine networks CXCR1 CYLD RELA PTEN STAT3 PMC7457372__F6 Signaling pathway by which C2S NPs promote osteogenesis through an autophagy effect ULK1 ATG3 SQSTM1 MTOR PMC10902128__F4 TGFB signaling pathway BCR TRADD SMAD2 APC SMAD4 TRAF2 FADD PMC7583994__F1 Rearranged in transfection (RET) receptor structure and its intracellular signaling pathway PI3 GDF15 FRS2 SRC GRB10 GFRAL IRS1 GRB7 DOK1 STAT3 PMC4716672__F3 Therapeutic Interventions to Disrupt the Protein Synthetic Machinery in Melanoma TBP PTEN MTOR POLI PMC4115620__F6 Pathway analysis for H3K9me3 enriched genes in baboon SVZ cells EPO NCK2 HEL-S-28 BMP2 MMP9 VEGFA VHL PTEN NACA RHO MTOR RSU1 HIF1AN RICTOR LEF1 ATM COPS5 MDM2 HEL-S-133P CDC42 SUMO1 PMC12076972__F5 KEGG enrichment results related to the potential targets of Gyp LI KIT CDK2 F2 EGFR VEGFA SRC HPSE NR1C1 PMC11944911__F6 D-LA biosynthetic pathway in engineered S MPC1 GPD2 GPD1 PMC3547636__F2 G Protein-coupled Receptor FPR1 as a Pharmacologic Target in Inflammation and Human Glioblastoma ANXA1 FPR1 EGFR CXCL8 SRC STAT3 PMC5067255__F7 Proposed model for the profibrotic regulation of GLUT1 expression by TGFB SMAD2 PMC7564075__F4 Signaling mechanisms of CD271 ROCK2 SORT1 HEL70 LIMK1 BRAF NGF ROCK1 NRAS NTS TRAF6 EZR ARHA RDX RTN4R NTF4 NTF3 GRB2 BDNF JUN PMC4147769__F2 Possible mechanisms of autophagy in mammalian cells PI3 ATG16L1 ATG12 ATG3 ATG10 MTOR ATG14 DKFZp686F0183 PMC8058227__F2 Ecdysone production and systemic release in response to dietary nutrient availability TSC2 TSC1 SMAD2 PMC4263456__F8 Myosin II accumulation and contractility are governed by a mechanosensitive control system IQGAP1 PMC8392544__F4 Applying Bioinformatic Platforms, In Vitro, and In Vivo Functional Assays in the Characterization of Genetic Variants in the GH/IGF Pathway Affecting Growth and Development STAT1 IGF1R SOCS3 IGF1 GHR STAT3 PMC3774790__F8 Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2 TH LMX1A CALB2 POU4F1 PITX3 WNT1 PMC9276970__F9 Extracellular Nucleosomes Accelerate Microglial Inflammation via C-Type Lectin Receptor 2D and Toll-Like Receptor 9 in mPFC of Mice With Chronic Stress NLRP3 TLR9 CLEC2D MYD88 IL1B PMC5488012__F1 Role of ROS in VEGF-mediated angiogenesis SRC NOX4 HIF1A STAT3 PMC3298530__F7 Tentative scheme for luteolin regulation of the IGF-IR signaling pathway in HT-29 human colon cancer cells CCNB1 MDM2 CCND1 IRS1 PMC3260001__F1 Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells ROCK1 CPN2 MDM2 GRB2 SRC RHO PTEN MTOR CASP8 CDC42 PMC9681871__F2 SMAD-(in)dependent bone morphogenetic protein (BMP) signalling pathway (oversimplification) SMURF2 ARHA SMURF1 PMC4253420__F7 Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERA and STAT5 PRLR SP1 PRL PMC4147769__F1 Simplified outline showing key proteins within the extrinsic and intrinsic apoptotic pathways in response to extra- and intracellular stress CASP3 CASP9 CASP8 FADD PMC8302405__F6 Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatigue TH KL FER NOG DES SP1 MAL PMC4223072__F11 Epithelial AvB3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components IL10 CARD9 IRAK1 SRC IL2 SYK IRF3 IRAK4 MYD88 PMC1436036__F12 Core signaling pathway downstream from V2R occupation in IMCD PDE1C STX7 PDE2A AVPR2 MYH10 ADCY3 PS1TP5BP1 HEL-S-162eP DKFZp686L0365 GRK4 RYR1 AVP AQP2 ADCY6 PDE7A PRKAR1B GNAS MYLK PMC3623872__F5 Nutrigenomics in Arma chinensis: Transcriptome Analysis of Arma chinensis Fed on Artificial Diet and Chinese Oak Silk Moth Antheraea pernyi Pupae BRAF INS EIF4E HIF1A MTOR RHEB TSC2 RICTOR TSC1 MAFK GRB2 EIF4B ELL PMC8914285__F3 New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases TLR4 IRAK1 IRAK2 VAV1 CCR7 TRAF6 CCL19 IRAK4 MYD88 PMC6694749__F5 PIKKs-related signaling pathway in the aging brain NRF1 ATM MDC1 ATMIN SSB ATR BRCA1 PMC155294__F4 Representation of the cell cycle control pathway within TIGR Orthologous Gene Alignment (TOGA) ATM CDK2 E2F2 MDM2 BCL2 CDK4 E2F3 CDK6 BAX PMC7573473__F4 BCL-2 family members and their role in the apoptotic pathway BAD BAX PMC7767993__F4 Key connectors of (A) T1D-bacterial infection in Wnt signaling pathway and (B) T2D-obesity in appendage morphogenesis MAPK3 MYC PSMB3 UBB PSMD7 PSMC6 AP2M1 HDAC2 SNX3 PSMA4 PSMB2 PSAP CALM1 HEL-S-276 CLTC PSMD6 PSMD2 VCP PSMD4 PSMD1 HEL-S-72p MYOD1 PSMD11 HEL-S-91n SDCBP TUBA4A EGFR MOV10 PFN1 UBC APP NEUROD1 YWHAG JUN HMGB1 EGR1 WNK1 NR3C1 DDX3X SKP1 TRIM29 PSMD3 BCL6 PSMB6 LMO4 LEF1 NFKB1 RELA ADRM1 HEL-S-93 TCF4 PMC11945976__F4 Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact XK XDH RPE PMC6321037__F2 S100A10 plays a key role in regulating pro-tumorigenic processes including proliferation, adhesion, motility, invasion, metastasis, and therapy resistance S100A10 PLG ANXA2 PMC4858120__F5 EGFR, HER‐2 and ER with downstream the RAS/RAF/MAPK and PI3K/AKT pathway BRAF EGFR PTEN MTOR PMC9221026__F1 Translational Regulation in mTOR Pathway TSC2 RICTOR TSC1 PTEN MTOR RHEB MLST8 PMC9654823__F6 Equus Beta-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage SYK CCL2 IL1B PMC9221026__F2 Translational Regulation in mTOR Pathway EEF2K LARP1 EEF2 EIF4E EIF4B PMC10550586__F4 Representation of the KEGG TNF Signaling Pathway, showing up-regulated (red boxes) and down-regulated (green boxes) genes CXCL1 CHUK BAG4 VEGFD TRAF3 NOD2 CEBPB MMP3 ATF4 CXCL6 JUNB CSF2 JUN IL1B SELE FOS PTGS2 MMP9 RIPK3 TNF BIRC2 EDN1 NFKBIA MMP14 LTA NFKB1 TRAF1 CSF1 TRAF2 FADD MLKL ITCH TAB3 PMC4835942__F1 Ca2+-mediated regulation of autophagy in the heart ULK1 CASR TFEB IGF1 MTOR DKFZp686F0183 PMC9692129__F7 Spatiotemporal characteristics of P-selectin-induced B2 integrin activation of human neutrophils under flow BTK RAP1A SYK PLCG2 PMC7883293__F8 ESM1 drives PCa metastasis by coordinating with the Wnt/B‐catenin pathway APC GSK3B ESM1 LRP5 LRP6 TCF4 PMC9143202__F9 Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells ATG3 NOTCH3 PMC8647113__F9 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases TH SHE COPA VILL COMP PMC8987494__F3 PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? PTEN EIF4E MTOR RHEB PMC11902984__F1 Pro-apoptotic TRAIL signaling pathway APAF1 FADD BAX PMC11172074__F1 Effect of miR-21 on the PTEN/AKT Signaling Pathway EGFR GRB2 SRC PTEN PMC4377205__F4 Gene interaction pathway PKP2 CS PKP1 TES ADA ABI3 PMC3425856__F4 CO prevents inflammatory responses via inhibition of NFKB signaling pathway VCAM1 MYD88 PMC4788817__F6 Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia TLR4 CRH AQP4 PMC3388509__F2 Inflammasomes and Intestinal Tumorigenesis STAT1 COX2 STAT3 PMC9024123__F4 Network Pharmacology Analysis of Huangqi Jianzhong Tang Targets in Gastric Cancer MAPK8 BIRC5 MAPK3 GSK3B MYC BCL2L1 RB1 HIF1A HMOX1 PRKCA MMP2 CASP9 MAPK1 SP1 CASP8 ABCB1 FOS YAP1 GSTM1 VEGFA HRAS GAST HEL-S-22 CCKBR RXRA CDKN1A CDK2 BCL2 TGFB1 PCNA EGF IGF1R NR3A2 EGFR PTEN MTOR TOP2A TLR4 CCND1 IL1B JUN BAX HRH2 MMP9 PTGS2 NFE2L2 CASP3 ERBB2 PIK3CA CYCS PMC1502529__F6 Network modeling PIK3R1 PLCG1 EGFR GIT2 CBL FYN JUP ERBB2 HGS PTPN11 GRB2 AXL SHC1 PXN PIK3R2 VAV2 PMC4067728__F3 Molecular actions of 1,25(OH)2D3 in inflammation and energy homeostasis in adipocytes TLR4 NR1i1 IL1B PMC11913854__F7 DHP-mediated apoptosis in HCT116 cells WAS FADD PMC9514424__F7 Multiomic analysis of dark tea extract on glycolipid metabolic disorders in db/db mice IL15 LTA PC AGA PGP LTB ARC CYP4F8 PMC11057055__F5 Identification of microRNA (miRNA) target genes PDE4A SMAD2 SNAI2 FBN1 CXCL8 SMAD4 HIF1A MYH10 SPHK2 MMP2 ZEB2 NOTCH1 MAPK1 SKI SP1 VPS35 ADAMTS2 RUNX3 CTSK PLEC FOS YAP1 WASF2 TP63 VCAN VEGFA GNA13 COL5A2 LAMA3 IGF1 CDKN1A FXR1 PRKAG2 RP2 ITGAV CXCL12 TOPORS MYH9 HGF PHLPP2 TPM1 RUNX2 COL3A1 ACTA2 TGFBR1 EGFR TGFBR2 PTEN ASPN MTOR C1QTNF6 COL1A1 AGTR2 ARGLU1 FOXF1 NR2F2 SCN2A CXADR COL1A2 CCND1 THBS1 TFAP2A DIPLA1 FGF7 IL10 EGR1 DKK3 FGF2 PTGS2 WASF3 ITGB1 WNT3A GJA1 ATP7A NEK2 RGMA NREP PPARG SMAD1 TRAF4 STAT3 PMC4791802__F5 Transcriptome and metabolic flux analyses in the central carbon metabolism in ST687 and ST1 (non-producer) strains PPIE AIP PPL FBP1 tal-1 HEL60 HEL-S-32 HEL-S-4 HEL-S-68p MPC1 ACO2 GPD1 MAL PMC3856398__F3 Ras-dependent versus Ras-independent extracellular signal-regulated kinase (ERK) signaling PAK1 LCK LAT PMC8129499__F4 Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction NLRP3 PDC TNF IL1B PMC10821092__F1 Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists BOC CDON KIF7 MOS SUFU GLI3 SMO GAS1 SPOP ADRBK1 PMC4865099__F6 Cluster analysis indicates a potential pathway for MWCNT-induced fibrosis based on two distinct phases HEL-S-62p CCR5 PTGIR CXCL1 CCL2 MYD88 TNF FCER1G IGF1 MMP12 CCL14 opn CCL17 FCGR2B ARG1 CCL3 PMC7641541__F2 CR2 site-targeted complement inhibitors CD59 FH CR2 CR1 PMC7641541__F3 Schematic graph showing that the complement system participates in the development of alcohol-induced liver disease HEL-S-62p TLR4 C5AR2 CYP2E1 PMC3471675__F6 Structural Insights into the Common Gamma-Chain Family of Cytokines and Receptors from the Interleukin-7 Pathway JAK3 JAK1 IL2RB PMC3985673__F5 Immune activation-related modules differentially correlated in NSCLC HLA-DOB FAIM ITK CD72 ABCB4 RASGRP3 RNF144A BASH HEL162 CD2 STAP1 CR2 RORA PMC9318596__F2 Exploring the Role of Staphylococcus aureus in Inflammatory Diseases NLRP3 RIPK1 LTA TLR4 RIPK3 TLR3 MLKL GSDMD PMC6347688__F1 Social rank on blood cell gene expression and regulation vary by species and treatment according to two new studies in PNAS (, ) TLR4 IRF7 GC IRF3 MYD88 PMC12153588__F10 FGF downstream multiple signaling pathways LIMK2 LIMK1 MAP4 GRB2 ARHA PMC7136425__F8 Compound BA-5 inhibits HSCs activation through blocking both TGFB1 and LPS-induced NFKB signaling pathways and further inhibits macrophage recruitment and activation BAMBI TLR4 SMAD2 COL1A2 SMAD4 MYD88 PMC6397540__F1 Proposed model of cell signaling associated with the ALK5-SMAD2/3 tumor-suppressive arm identified by Monsivais et al BMPR2 ACVR2B ACVR2A SMAD2 TGFBR2 SMAD1 DKFZp781O1323 PMC4663246__F1 Cyclin D1-cyclin-dependent kinase 4/6-retinoblastoma 1 pathway CDK4 RB1 CDK6 PMC6544049__F1 Circadian rhythms and memory formation CRY1 CRY2 DBT PER2 PMC10125773__F5 TNFA signalling pathway TRADD TRAF3 CSA2 TNF TRAF2 FADD PMC4762924__F1 Key pathways of glycogen synthesis and metabolism GYS2 NUDT14 GYS1 PYGB AGL PYGM PYGL PMC10125773__F3 IL-1A and IL-1B synthesis and signal transduction pathways IRAK1 TRAF6 IL1R2 MYD88 PMC11522688__F9 Schematic illustrations of AMSC-EV and HUMSC-EV repairments on photoaging in vitro and in vivo via regulation of the TIMP1/Notch pathway (Created with BioRender TIMP1 MSC NOTCH1 ADAM10 SIRT1 HES1 PMC3596529__F1 Intrinsic control of axon regeneration TSC2 PDK2 PTEN MTOR PMC8066579__F4 RLR, TLR and JAK-STAT signalling pathways and interference of signalling pathways by structural and non-structural proteins of coronaviruses TANK STAT2 IRF9 TRAF3 TRAF6 MYD88 TLR3 STAT1 TLR7 NPL IL2 TYK2 MAVS STAT3 PMC6323178__F5 Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway TBK1 TLR4 SRC IRF3 PMC3070659__F1 Representative axon regeneration-regulating pathways discovered in genetic model organisms CNTF SOCS3 FOS PTEN PMC8577691__F3 STRING analysis of habenular proteins with increased levels after (−)-menthol exposure GAD2 TUBA4A CETN2 BRAF TPH2 TAOK1 NF1 PSMD7 SEC24C SEC31A PSMC6 PAICS DCTN1 NUDT2 COPS7A AP1G1 PCBD1 GLA TRAPPC1 CTPS2 FASN UBE3A CCT6A RNF123 PPP5C DNAJC5 TUBGCP6 ANAPC2 TRAPPC13 HEL-S-87p NEDD4 PSMD3 SPR TCP1 ZNF547 PMC3889478__F1 Comparison of in vivo (left) and in vitro (right) signaling support to the intestinal stem cell EGF WNT3 WNT9B WNT2B PMC10982685__F1 Integration of Psat1 into glycolysis and the serine biosynthetic pathway and its contribution to additional signaling mechanisms PSAT1 ATF4 PSPH PHGDH PMC3153486__F5 Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT1) Receptor Blockade ACTA2 ASPH ACTA1 TNNT1 TNNC1 TNNC2 TNNI1 ATP2A2 ATP2A1 TRDN PMC7583347__F1 S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease GCLM TRPV4 KEAP1 NRP1 GC NQO1 PMC9704760__F5 An example paths-between query to find the two distinct directed links between two simple chemicals in the Urea cycle pathway with k = 7 OTC NAGS ASS1 ASL PMC8431939__F3 CD112R/CD112 axis: a breakthrough in cancer immunotherapy CD96 TIGIT CD226 PMC4434687__F4 Conversion of tabersonine to 3-hydroxy-2,3-dihydrotabersonine by the combined action of T3O and T3R enzymes MIA3 DIO1 MIA PMC4582117__F8 Schematic of the VEGF-A/NRP1 signaling pathway to promote cancer cell proliferation NRP1 ARHA PMC2671717__F7 Schematic Overview of Pyrimidine de Novo Synthesis, Salvage, and Degradation.Nucleotides synthesized de novo enter the nucleotide pool and become further converted to nucleic acids and other metabolic intermediates UPRT INS CP PMC8130408__F1 Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway mediated by nicotinamide phosphoribosyltransferase (NAMPT) and circadian NAD+ oscillation NAMPT SIRT6 SIRT1 PMC11019464__F2 Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review) IMPACT APC LRP5 LRP6 PMC3525723__F4 Insulin signaling transduction BAD RBP4 MTOR BAX PMC7251756__F1 Glucose Metabolism and De Novo Lipogenesis (DNL) in Adipocytes CS ACSS2 ACLY FASN PMC4326637__F1 Biology of Advanced Uveal Melanoma and Next Steps for Clinical Therapeutics RHO PTEN MTOR TRIO PMC3989634__F2 Myeloid differentiation primary-response protein 88 (MyD88)-dependent and MyD88-independent TLR-4 signaling pathway TBK1 HMGB1 IRAK1 TRAF6 IRF3 IRAK4 MYD88 PMC11809005__F3 Reconstruction of the ginsenoside biosynthesis pathway in PN flowers, with expression profiles of structural genes across the six developmental stages MVD FDPS MVK HMGCR PMC6723199__F1 The metabolic pathway of caffeine NAT2 CYP2A6 CYP1A2 CYP2E1 PMC4758349__F2 AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity STAT1 CGAS STAT2 IRF9 GBP2 GBP5 IFNAR2 IFNAR1 AIM2 IL1B IRF-1 PMC7566803__F7 IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells ATM BLM MDC1 H2AX JUN MON2 TDP1 PMC3359655__F1 Central IR/IGF-1 signaling PI3 IRS4 IGF1R PDK2 GSK3B APP PTEN IRS1 PMC4317318__F2 Immunologic synapse APC PTPN22 FOXP3 PMC8698755__F5 Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer PIK3CD PIK3R1 SOCS2 SOCS3 BRAF PRR5 PIM2 MAPK3 MYC AKT1S1 PTEN MTOR STAT5B RPTOR STAT1 PIM1 SOCS4 SOCS7 MAPK1 ARAF STAT2 MAP2K2 HRAS PIK3R3 DEPTOR PIK3C2G MAPKAP1 PIK3R4 MLST8 PIK3C2B PIK3R5 RICTOR MAP2K1 IGF1 PIM3 STAT4 PIK3CA BCL2 JAK3 TYK2 JAK1 RAF1 SOCS5 SOCS1 PIK3R2 AKT3 STAT3 PMC6040266__F7 Mitochondrial sulfide-oxidizing pathway HEL-S-62p RHOD ETHE1 PMC8422911__F10 cartoon illustrating the mechanisms by which deficiency of Adam15 leads to exaggerated COPD in mice CXCR3 ADAM15 MTOR PMC2173906__F7 Hypothetical scheme of the mechanism by which Dkk1 promotes osteolytic lesions in vivo WNT3A BMP2 DKK1 PMC10177541__F9 Effects and mechanisms of SQSTM1/p62 on migration and invasion of HCC MMP2 KEAP1 MMP9 PMC4346117__F3 Evolutionary model of non-spatial clustered metastatic ovarian cancer WAC ARNT2 PMC8586976__F4 Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics CDK2 BCL2 BAX PMC7882715__F3 Possible mechanism of polymorphism influences related with MAPK and PI3K/AKT cell signaling CYP2C19 UST UGT2B7 PMC6740038__F3 The Keap1-Nrf2 signaling pathway KEAP1 GSK3B SKP1 RBX1 PMC7677104__F5 New, potential drugs targeting mainly immune cells, adapted and modified from Michalak BTK HEL-S-171mP IL2 SYK MTOR PMC5818881__F9 SYK and downstream kinases are essential to drive inflammation and blistering in experimental epidermolysis bullosa acquisita (EBA) PLAUR FPR1 SYK NCF1 PMC8584226__F3 Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases PC LPA MTOR PMC6740038__F1 The dual roles of Keap1-Nrf2 signaling pathway in pancreatic cancer KEAP1 RBX1 PMC6425516__F1 Epigenetic regulation of peroxisome proliferator-activated receptorA (PPARA) in fatty acid oxidation (FAO) genes (A–C) and PPARA signaling to the FAO metabolome (D) DKFZp666G145 HEL-S-11 SIRT1 RXRA CD36 PMC3103541__F8 Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex CORT PTEN MTOR PMC9013863__F2 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma EGFR MYC GRB2 PTEN SOS1 PMC9013863__F3 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma RICTOR TSC1 SOX2 PMC2749675__F1 Scheme of the Wnt signaling pathway NLK DAAM1 APC GSK3B LRP5 LRP6 PMC9013863__F4 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma MDM2 CCND1 BCL2 CDK4 CDK6 STAT3 BAX PMC6696356__F7 Scheme summarizing the protection of AB25–35-induced SH-SY5Y cell mitochondrial dysfunction by ginsenoside Re via inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response pathway MAF GCLC BAX PMC7154970__F2 Regulatory roles of microRNAs in Tregs STAT1 NFAT5 SMAD2 NCOR2 IFNG STAT3 FOXP3 PMC6657153__F7 Schematic representation of Notch1-mediated regulation of Akt signaling disturbed by TDP-∆C protein NOTCH1 PTEN HES1 PMC4332439__F7 Interplay model of Wnt/Beta-catenin, LPS/TLR4, and growth factors in ENS TLR4 IRAK1 APC GSK3B LBP TRAF6 IRAK4 MYD88 TIRAP PMC4711038__F5 Altered gene expression in the JAK/STAT signaling pathway during diapause NOP56 PAIP2 PMC4711038__F9 Altered gene expression in the JNK signaling pathway during diapause HEL70 TRAF6 RAC1 TRAF4 PMC6740038__F4 Targeting Keap1-Nrf2 signaling pathway for pancreatic cancer prevention and therapy KEAP1 GSK3B SKP1 RBX1 CP PMC5179564__F7 Acetylation of central metabolic enzymes in desiccated embryos HEXA ACADL ACACA ACADVL FADD ACADM ACOX1 FASN PMC6174285__F1 Cyclic nucleotides signaling pathway in plant cells GC PSIP1 PMC5551552__F5 Schematic summarizing findings and proposed mechanism of placental lipid metabolism in obese women DGAT1 DBP ADFP CYB TG NR1C1 PMC7825801__F2 Cholesterol synthesis pathway PMVK MVD DHCR7 DHCR24 MVK IDI1 HMGCS1 HMGCR PMC7411426__F2 Targets of hsa-miR-1307 PDX1 RAB35 BAD PDK2 GSK3B INS MTOR IRS1 FOXO1 RHEB INSR RAB10 TSC2 TSC1 FGFR1 TAP2 CDC42 PMC3762275__F2 Recognition of particulate and soluble Beta-glucans by dectin-1 and signal transduction in macrophages and DCs NLRP3 CARD9 IL16 PC IRAK1 SRC TRAF6 SYK IRAK4 MYD88 PMC7825801__F3 Fatty acid metabolism CPT1A FASN HTD2 HEL-S-5 PMC6323203__F1 Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed proteins HEL-S-62p APC ELL PMC12210502__F7 The molecular interactions and signaling pathways involved in the association between TSC and renal cell carcinoma development (by Figdraw) TSC2 TSC1 TFEB GPNMB PMC3590661__F1 Schematic overview of the impact of HDACi on DSB signalling, HR and NHEJ DNA repair pathways ATM BRCA2 RAD50 RAD51 H2AX MRE11A BRCA1 PMC12210502__F8 The molecular interactions and signaling pathways involved in the association between TSC and renal angiomyolipomas development (by Figdraw) TSC2 TSC1 PMC12210502__F5 The molecular interactions and signaling pathways involved in the association between TSC and diabetic kidney disease development (by Figdraw) TSC2 TSC1 MTOR DEPTOR MLST8 PMC12210502__F6 The molecular interactions and signaling pathways involved in the association between TSC and renal cysts and polycystic kidney disease development (by Figdraw) BAD TSC1 FNIP1 PKD1 PMC12210502__F3 The molecular interactions and signaling pathways involved in the association between TSC and acute kidney injury development (by Figdraw) TSC1 MTOR DEPTOR RHEB PMC12210502__F4 The molecular interactions and signaling pathways involved in the association between TSC and renal fibrosis and CKD development (by Figdraw) TSC2 TSC1 MSC TRIM6 MTOR DEPTOR MLST8 PMC4061041__F6 ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence EGR1 IGF1R IGF1 ATM PMC12210502__F1 Patterns of TSC1/2 role in kidney disease (by Figdraw) TSC2 TFEB MDM2 FNIP1 FOXI1 PKD1 RHEB PMC12210502__F2 TSC1/2 signaling pathway (by Figdraw) TSC2 RICTOR PTEN MTOR DEPTOR RHEB MLST8 PMC6437992__F1 ABT cell receptor (TCR) signaling pathway PLCG1 ARHH APC LCK VAV1 ZAP70 GRB2 TRAF3IP3 THEMIS SOS1 LAT PMC4285849__F1 Impact of IBD genetic polymorphisms on dendritic cell function IL10 ATG16L1 NOD2 PMC3078497__F1 Effector signaling pathways activated during ischemia preconditioning BAD GSK3B STAT3 PMC3133356__F7 Model showing the role for Bmi1 in the DNA damage response pathway RNF8 ATM SSB BMI1 ATR H2AX BRCA1 PMC8093290__F6 Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway NLRP3 VASP TLR4 IL1B PMC8699297__F2 Impact of a Faulty Germinal Center Reaction on the Pathogenesis of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System BTK CARD11 TBL1XR1 BCL10 BCR BASH PAX5 MYC MYD88 CDKN2A CD79A CBL PMC7797784__F6 Proposed mechanism of action of JC-5411 via activation of Nrf2 pathway against arteriosclerosis NLRP3 GCLM KEAP1 GCLC CPT1A LDLR IL1B PMC5179308__F7 Pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease SMAD2 FAP STAT3 PMC3612022__F6 Proposed synergistic pathway to mitotic cell death in cells treated with a combination of paclitaxel and gefitinib or the PLK1 inhibitor BI2536 PLK1 WEE1 PMC2834195__F1 The circadian clock signaling pathway NPAS2 PMC10311893__F5 MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study RPL11 FOXO3A BMP2 GHR TCF7L2 LEPR DYRK2 NFYB NCOR2 IL18R1 PMC4511633__F3 Hypothetical model of insulin resistance development in response to nutrition overload NOX4 IRS1 INSR PMC4783088__F2 Regulation of hepcidin antimicrobial peptide (HAMP) expression EPO HAMP EBP GDF15 HFE TFR2 PMC5794012__F4 An overview of the main metabolic pathways affected by the storage lesion in RBCs during routine storage in the blood bank LAT MAL PMC12205195__F14 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma LEP POMC SOCS3 TRADD NPY AgRP LEPR MTOR TRAF2 NR1C1 STAT3 PMC4810129__F2 Effects of virus mediated targeting of PDZ proteins often converge on the PI3K/AKT signal transduction pathway PDLIM2 SCRIB PTEN LPA NHERF1 PMC12205195__F15 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma FOS EGFR GRB2 SHE HBEGF MTOR JUN PMC6166676__F1 Study design PTPN11 PMC8677728__F1 Targeting PI3K/Akt signal transduction for cancer therapy TBK1 IGF1R EGFR TRAF6 PTEN TSC2 TSC1 IGF1 BCR ATM FRS2 GRB2 ATR PMC11005958__F1 Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo MYH9 PTN APC HEL-S-92n PMC8677728__F2 Targeting PI3K/Akt signal transduction for cancer therapy TSC2 MDM2 PMC8674309__F1 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment TBK1 CGAS TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 IFNLR1 STAT1 IL18 TLR7 TLR4 JUN IL1B IRF9 IRF3 IFNAR2 IL6 IFNAR1 TLR3 IL10RB RELA TYK2 JAK1 MAVS TAB3 PMC8674309__F2 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment IL15 CCL5 CD80 CCL2 IFNG PMC8674309__F3 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment STAT1 CGAS STAT2 IRF3 CD80 TLR3 PMC8674309__F4 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment STAT1 IRF7 IRF9 IRF3 IFNG PMC5539397__F1 Effect of RBBP5 inhibition on glioblastoma TBK1 TLR4 SOX2 PMC3023527__F7 Schematic summary of the results showing the consequences of mPGES-1 mediated PGE2synthesis for LPS-induced neuroinflammation IL16 TLR4 IL1B PMC11673720__F2 A-to-I editing in mRNA coding region resulting in missense mutation ADAR COPA ARHA FLNB MTOR PMC11673720__F4 Regulatory mechanisms of A-to-I editing on Alu ROCK2 ADAR ROCK1 ARHA MAVS PMC4396475__F11 Casein kinase 1A–dependent feedback loop controls autophagy in RAS-driven cancers BNIP3 MTOR PMC6627192__F4A Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs E2F8 PRR11 KIF23 CCNA2 CDKN3 MARK1 GINS1 AHR MT2A UNK MCM10 JUNB GINS2 GMNN JUN RBL1 CCNE2 NUSAP1 TSC22D3 CEP55 UBE2C E2F7 CDC6 EVI1 RORA SHCBP1 DOCK7 PMC10178966__F3 Potential biotargets associated with the CI−AKI NLRP3 TLR4 IL33 TXNIP TET2 BAX SIRT3 PMC11430655__F1 Interaction network constructed for genes involved in central carbon metabolism in cancer (hsa05230) limited to Homo sapiens (https://genemania SLC7A10 CLYBL ENO4 RUNX2 SLC7A11 PPM2C PDPR ENOSF1 NAALAD2 NR2F1 PDP2 PKLR hEMMPRIN PGAM1 HEL-S-133P PGAM2 HEL-S-281 ENO3 RUNX3 RUNX1 HEL-S-30 LAMA4 SLC7A5 AGER ENO2 SLC3A2 SLC25A1 PMC11430655__F2 Graph representing the interaction network of AGER (the gene encoding RAGE) with genes encoding RAGE ligands HMGB1 CAPZA2 EGFR IRAK4 S100A12 S100A1 S100B CAPZA1 SFTPB ITGAM AGER NFKB1 RELA S100A8 MAPKAPK5 S100A4 PMC5126201__F1 Adenosine pathway mediates immune suppression APC ADA PMC84078__F7 Schematic of the influence of Notch on MEF2C and myogenic bHLH factor interactions MEF2C MEF2D PMC5719258__F5 An integrated model for valve development NFATC1 EFNB2 UGDH PROX1 CELSR1 FOXC2 EPHB4 GATA4 GATA2 SDC4 TBX5 KLF2 PECAM1 PMC7414235__F1 Gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) CCL25 MTOR ACE2 PMC10888452__F1 The PI3K/AKT signaling pathway and its activation TSC2 BAD TSC1 MDM2 TRAF6 PTEN PMC7933442__F1 Hypothetical model showing how alpha1-antitrypsin (AAT) may affect staurosporine (STS)-induced apoptosis and autophagy in NSCLC cells STS F2 CAD MTOR DKFZp686F0183 PMC11430655__F5 Graph representing the interaction networks of selected genes HELLS ENO3 SLC7A11 PDK2 ENO1 NAALAD2 NR2F1 LAMA4 MTOR PDK4 ZFP57 DNMT3B RNF44 F8A3 CBFB SLC7A5 SALL3 KLHDC9 MCAM PKLR ENO2 SLC3A2 TRIM28 DNMT3L PMC3421232__F5 Network of 25 target genes and their interactive genes involved in regulating apoptosis and autophagy BAD CASP12 TRADD IRAK2 MTOR CASP10 PIK3R4 CASP3 CASP9 PIK3CA ATG14 CASP8 FADD FASN PMC7796313__F1 Therapeutic targeting of TGFB in cancer: hacking a master switch of immune suppression SMAD2 SMAD4 PMC11430655__F4 Graph representing the interaction network of Diaph1 with proteins involved in cytoskeletal dynamics HMGB1 VASP LIMK1 RTKN HEL-S-15 ACTA1 SSH2 ARHA S100A12 S100B PFN1 PS1TP5BP1 DAAM1 SSH3 ERBB4 DIAPH2 AGER PFN3 PFN2 RELA SSH1 PMC5328816__F6 A schematic representation of carbon metabolism in wine yeast, including glycolysis, pentose phosphate pathway and tricarboxylic acid (TCA) cycle HEL-S-26 ACO2 BDH1 ENO1 ENO2 GPD2 tal-1 HEL60 MDH2 GPD1 HEL-S-68p PMC9035535__F1 Gut Microbial Community and Host Thermoregulation in Small Mammals TLR4 UCP1 SLN UCP3 PMC6745797__F1 Major hallmark of immunosuppression in the TME through diverse pathways in EGFR-mutant NSCLC AREG EGFR GSK3B CCL2 FOXP3 PMC7796135__F1 Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis STAT1 COX2 TNF STAT3 PMC3508619__F1 MYC proteins and the p53/MDM2/p14ARFpathway MDM2 BAX PMC6745797__F2 Intrinsic cancer cell pathways mediate the regulation of PD-L1 expression and MHC in EGFR-mutant NSCLC MHC2TA EGFR GSK3B MYC CDC37 MTOR PMC8784548__F1 Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/Beta-Catenin Signaling APC GSK3B LRP5 LRP6 SIK1 CFTR MAF MMP7 RSPO1 MMP2 DOCK4 CRP FHL2 PMC9064286__F3 Determinants of tumor sensitivity to GLS inhibitors HEL-S-26 PC KEAP1 SLC7A11 MTOR GATA3 GLS PMC3213765__F12 Schematic of the sonic hedgehog signaling pathway SUFU SHH SMO PMC3089575__F8 Proposed interconnection between PE synthesis and conversion (PL interconversion triad) during LD biosynthesis PC TG PSD PEMT PMC3213765__F13 The sonic hedgehog signaling pathway in the primary cilium SUFU SHH CCND1 SMO CCND2 PMC7985832__F2 TREX1 dysfunction triggers the cGAS-STING cytosolic DNA sensing pathway TBK1 CGAS TREX1 IRF3 PMC3213765__F17 Wnt signaling pathway APC AXIN1 CCND1 AXIN2 PMC11003766__F5 The BTN2A1-BTN3A1-BTN3A2 complex regulation FDX1 DPM2 RFT1 CMAS SLC35A1 NANS ALG3 ALG12 GCS1 B4GALT2 NARF HSCB NUBP1 NFU1 GMPPB IRF-1 NANP MAN1A2 FDXR MAN1A1 ST6GAL2 ALG9 RER1 MAN1B1 ABCB7 CIAO1 DPAGT1 ALG13 GANAB MGAT3 FXN MAN2A2 FES ISCU RPN2 MAN2A1 MGAT5B ALG5 MGAT5 MGAT1 SRD5A3 MPDU1 RPN1 DOLK MGAT4C MGAT4D LYRM4 DOLPP1 DPM1 MGAT4A MGAT4B STT3A ZNF217 HEL-S-62p CTBP1 ALG8 ALG6 ALG10 B4GALT1 TUSC3 BTN2A1 GNE RUNX1 DPM3 ALG1 STT3B MGAT2 DDOST ST6GAL1 PMC6996360__F3 Genes involved in hedgehog, Wnt, TGF‐B, and p53 signaling pathways were differentially expressed during developmental BA SUFU APC PTCH1 SHH SMO PMC4298325__F6 A, Diagram of the prostaglandin synthesis pathway including relative expression values (arbitrary units) for synthetic enzymes and receptors from our previously reported microarray analysis of bovine growth plate chondrocytes () COX1 PMC3361623__F3 A New Framework for Understanding IRES-mediated Translation EIF2D EIF2A DENR PMC6996360__F2 Genes involved in Wnt, PI3K‐Akt, MAPK, TGF‐B, microsatellite instability, and p53 signaling pathways were differentially expressed during developmental BA CASP3 BAD SMAD2 APC MSH6 CASP9 SMAD4 BCL2 RHO MSH2 DCC PMC3361623__F1 A New Framework for Understanding IRES-mediated Translation ELF5 ELF3 EIF4H EIF4B EIF5 PMC8971815__F2 Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy SMAD2 GSK3B SMAD4 PMC4536527__F8 Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1A pathway in chondrocytes TLR4 HIF1A IL1B PMC10526873__F1 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology EGF EGFR SRC HBEGF TNF PMC12035766__F1 Brief diagram of the mechanisms of molecular hydrogen TLR4 ATF4 TRAF6 XBP1 BAX FOXP3 PMC10526873__F2 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology EGFR SRC ARHA KLF2 MEF2C PMC4569588__F4 Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach RET PIM2 ATR PMC4320069__F1 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants MLPH MAP2 SKIL KLF5 FGFR2 SOX9 MAP2K1 VGLL3 SP4 IRX2 KLK3 KLF4 KCNJ2 TBX5 NKX3-1 PMC8318284__F1 Network analysis of 12 miRNA-mRNA interaction pairs associated with OS in EOC patients CH25H NAMPT POSTN HBB ATF3 HBEGF PROCR EMP1 PMC3539150__F1 Schematic diagram illustrating the specific cascade and signaling pathway in LPS-primed macrophages stimulated with MSU, silica, or alum salt crystals IL16 PIR IL1B PMC4320069__F4 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants NGFR ITGA6 FGF10 KLK3 URI1 TMEPAI MSMB NKX3-1 CLDN11 TERT PMC12035766__F3 Molecular hydrogen alleviating IBD and intestinal injury ATF4 APC XBP1 GSDMD IFNG PMC4320069__F2 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants KLF5 MYC FGFR2 SOX9 MMP7 LEF1 ITGA6 FGF10 KLK3 KLF4 MSMB GATA5 NKX3-1 CLDN11 TERT PMC12035766__F4 Molecular hydrogen reducing intestinal I/R injury IRAK1 IRAK4 PTEN TF GSDMD PMC4320069__F3 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants MMP7 MLPH SKIL DKFZp781B1423 BIK FGF10 KLK3 MSMB TCF2 NKX3-1 CLDN11 TERT PMC12035766__F5 Molecular hydrogen inhibiting CRC growth TSC2 TSC1 RHEB PMC2798195__F9 Proposed mechanism for pathogenesis due to H CD14 TLR4 TLR1 PMC6534778__F2 TLR4 signalling in hypertension and potential therapeutic targets TBK1 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 IL1B TAB3 PMC5469213__F2 Tuberous sclerosis complex and mTOR pathway TSC2 TSC1 RHEB PMC6406290__F10 Scheme of proposed IS-induced apoptosis via ROS-NRF2 and MAPK signaling pathways in human astrocytes DUSP5 DUSP8 ROS1 PMC11834690__F1 Production of insulin and the classical insulin signaling pathway TSC2 TSC1 PTEN RHEB PMC7824062__F1 Competition of 2-OBA and Pyr in the l-threonine-overproducing E NR1A2 THRA PMC8766339__F7 Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab AMOT KPG_011 YAP1 PTEN LATS1 RHO EIF1AX MTOR LATS2 ARF6 SDE2 TRIO STAT3 TERT PMC3213765__F20 Shh and BMP signaling GIG8 ATOH1 SHH ID1 PMC2063755__F1 Signaling events during EMT LEF1 HEL-S-28 SMAD2 GSK3B SRC HDAC2 FOXC2 CRK HDAC1 MTA3 PMC8781887__F1 Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond PCK1 FBP1 ATF1 CLP1 PCK2 PMC4887211__F9 Proposed working model for Fbxo21-mediated innate antiviral response SKP1 MAP3K5 NEDD8 RBX1 FBXO21 PMC5234836__F5 Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway PARP14 IFIT3 PLSCR1 IFIT2 RSAD2 IRF7 IRF9 EIF2AK2 IFITM1 MX2 MX1 DTX3L ISG15 OASL SP110 OAS1 OAS2 OAS3 XAF1 LGALS3BP TGFA IFI6 IFIT1 PMC4706383__F8 The proinflammatory role of HECTD2 in innate immunity and experimental lung injury TLR4 GSK3B PIAS1 TNF PMC8855927__F1 Itaconate, Arginine, and Gamma-Aminobutyric Acid: A Host Metabolite Triad Protective Against Mycobacterial Infection NLRP3 MCC TLR4 TNF IRF-1 PMC11017435__F1 NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease TRADD FADD BAX PMC9261345__F1 NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction NAMPT ATM SARM1 ATR SIRT1 PMC6771568__F2 IGF signalling pathway alterations occurring in cisplatin‐resistant TGCT IGF1R PIK3CA PTEN PMC10973144__F2 Protein glycosylation is closely interconnected with glycolysis and other metabolic pathways PGM3 OGA STS OGT PMC8033311__F1 Classical necroptosis signaling pathway initiated by the combining of TNF ligand and TNF receptor 1 TRADD FADD MLKL PMC10973144__F3 Pathological macrophages that promote inflammation or fibrosis have altered metabolism as a results of lung injury CD14 CHIT1 NEU1 STAT3 PMC6755353__F1 The endosomal Toll-like receptor 7 (TLR7) in remodelling of the infarcted heart HMGB1 TLR7 IRAK1 IRAK4 MYD88 IL1B PMC5321214__F1 Coupling of toxic and pro-inflammatory lipids and innate immune response TLR4 MYD88 CD36 PMC12230849__F4 MiRNAs regulate the proliferation and migration of VSMCs KEAP1 MEF2C PMC12230849__F5 Factors influencing VSMC apoptosis and their signal pathways IGF1 APAF1 TRAF6 MCL1 PMC12230849__F6 Autophagy in VSMCs and its influencing factors DUSP5 TFEB ATG2B MTOR ATG14 DKFZp686F0183 TRPV1 PMC11701794__F2 CEMIP affects the PI3K/AKT, EGFR, and Wnt/B‐catenin signaling pathways, which contribute to cancer progression by promoting cancer cell growth, angiogenesis, and proliferation, while also inhibiting cell death SEMA3A CEMIP SLC7A11 EGFR NR1C2 ASCL2 PMC4891345__F1 Genes and biological processes shared in Parkinson’s disease (PD) and cancer SNCA PINK1 COX2 LRRK2 PTEN MTOR PMC11701794__F3 CEMIP‐related hyaluronan (HA) degradation occurs through rapid vesicle endocytosis CEMIP EGFR HYAL2 CD44 HAS1 HAS3 HAS2 PMC3982925__F1 PGD2 pathway in alopecia COX2 COX1 PMC6397983__F12 The insulin-like growth factor system role in PMSC differentiation into the skeletal muscle SOX2 IGF1 IGF2 PAX7 IGFBP6 MTOR PAX3 IRS1 MYOG PMC4575611__F1 An outline of the inhibition of type I IFN signaling pathways by viral proteins of KSHV CGAS TLR4 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR3 IFI16 PMC3683896__F2 Extrinsic and intrinsic pathways of apoptosis APAF1 FADD PMC7959785__F2 Biosynthetic pathway of selenoprotein translation GPX4 SEPSECS SEPHS2 GPX1 PSTK PMC7924631__F1 Overnutrition leads to increased gluconeogenic gene expression by altering gut microbiota and lipopolysaccharide (LPS) production CD14 TLR4 CRTC2 XBP1 FOXO1 PMC7722981__F2 Type 1 diabetes mellitus as a disease of the Beta-cell (do not blame the immune system?) STAT1 PDX1 TLR4 TLR9 CXCL10 MYD88 IL1B IRF-1 TLR3 PMC7924631__F2 IRS acetylation by abnormal cytoplasm-appearing P300 causes insulin resistance INS CRTC2 IRS1 FOXO1 PMC5385611__F1 Cell migration induced by EGF via regulated alternative splicing of the Rho GTPase Rac1 SPSB1 EGF EGFR RAC1 PMC5743619__F1 Schematic presentation of different pathways involved in PCa disparity.1 IL10 EGF IL6 MTOR STAT3 PMC4527420__F1 A simplified representation of endocannabinoid synthesis and degradation pathway COX2 PC DAGLB DAGLA FAAH PMC10943956__F2 SASP regulation of aging intervertebral disc cells converges on the p53/p21 and p16/Rb pathways TBK1 TSC2 CGAS TSC1 ATM SSB PTEN H2AX PMC11500330__F3 Radiation-induced skin fibrosis and OS SMAD2 SMAD4 NOX4 SP1 PMC2734563__F2 Possible mechanisms of UbcH7 regulation of Chk1 levels sand S phase BARD1 MCM7 PTEN BRCA1 PMC7029350__F8 Both extrinsic and intrinsic pathways converge in the same terminal execution pathway, which is initiated by the cleavage of caspase-3 TRADD FADD BAX PMC3721230__F1 Mechanisms of action of lipopolysaccharide (LPS) as a sepsis inducer CD14 MYD88 TNF PMC7382779__F4 Functional Relationships by Gene Ontology (GO) Enrichment Analysis of Protein Regulation Networks and Phosphorylation Regulation Networks HEL-S-49 ASTE1 ENO1 HEL-S-68p PMC7029350__F6 Wnt signaling is regulated by the cytoplasmic Beta-catenin destruction complex, which consists of the core proteins AXIN, adenomatous polyposis coli, casein kinase 1, and glycogen synthase kinase 3 APC LRP5 CCND1 LRP6 PMC4530250__F2 GDF-15 regulates signaling pathways essential for cardioprotection BAD ALK EGFR SMAD6 PMC3729336__F1 Schematic overview of the kynurenine (KYN) pathway IDO1 KMO IDO2 PMC7029350__F5 Class I PI3Ks activated by receptor tyrosine kinases, such as epidermal growth factor receptor, can phosphorylate PI 4,5-bisphosphate to yield PI 3,4,5-triphosphate in the cell membrane BAD GSK3B PMC2733936__F1 Targeting the ASK1/MKK4/JNK pathway upstream of mitochondrial prodeath signaling BAD TRAF2 BAX PMC8634471__F2 Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer COX2 TLR4 IGF1R EGFR GSK3B PTEN PMC7156217__F9 Possible model for the CD40 signaling mechanisms TBK1 TRAF3 TRAF6 CD40 TRAF2 PMC6978796__F3 Roles of defective mitophagy in AD with a vicious cycle between them USP15 CDK5 PARP1 USP35 USP30 OPTN PMC6755251__F4 T-cell receptor signaling pathway IL10 ITK FYN BCL10 DAO LCK GRB2 CDK4 IL4 LAT CBL PMC6054540__F9 Regulation of hepcidin in breast cancer spheroids BMP6 SMAD4 STAT3 PMC6834141__F2 Simplified overview of the signaling pathways in the target cells presented in this review that are relevant for the development of a pharmacological therapy rationale IGF1 LIF CCND1 FADD STAT3 PMC7343963__F6 Construction of correlation network EGR1 ZFP36 FOS ADRB2 PMC3645912__F1 Induction and maintenance of IDO in dendritic cells AHR FOXO3A CD80 STAT3 FOXP3 PMC11948861__F3 Autophagy-mediated ferroptosis GPX4 ATG16L1 HPCAL1 SLC7A11 HIF1A MTOR WBP2 DKFZp686F0183 MARCHF6 TFEB ATF4 DHFR SLC40A1 CDH2 ATG9A HEL-S-29 PMC11948861__F4 Autophagy-mediated other forms of RCD HMGB1 ATG12 APC HEL-S-99n PARP1 UVRAG ATG10 MTOR DKFZp686F0183 WDFY3 PMC2780394__F7 The signaling network of differentially expressed proteins PRKCA BAD CDK2 RELA TP63 CDK4 TFF3 CHEK1 CDC42 CAMKK1 PMC3206090__F5 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development TSC2 TSC1 IGF1 PSEN1 HTT GSK3B MTOR PMC3206090__F2 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development NGF HTT APP BDNF HAP1 PMC12223711__F3 Function of NDR1 and other NHLs in PTI and ETI responses RPS2 BAK1 PMC5629826__F1 Dopaminergic pathway genes and serotonergic pathway genes TH DRD5 DRD3 HTR1B DDC MAOA DRD1 HTR2A DRD2 DRD4 PMC3730337__F1 HDACi and DNMTi target the MM cell ATM APC ATR PMC2974943__F2 Intracellular signaling pathway within cranial neural crest cells mediated by endothelin-1 (Edn1) EDN1 ECE2 FURIN ECE1 PMC8204192__F4 Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake FES C6 TK1 HEL-S-5 PMC8533927__F1 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers KEAP1 YAP1 PMC8533927__F2 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers IGF1R FGFR1 ERBB2 ERBB3 AURKA PMC11048239__F1 Flux-independent signaling pathways activated by AMPARs in neurons LYN ARC BDNF PMC8210594__F1 Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease KIT CGAS IER3 RUNX1 CTLA4 FOXP3 PMC6567134__F8 Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation APOA4 MOGAT1 LPIN1 CIDEC TG CIDEA FASN CD36 PMC4522390__F1 The Repeat Expansion Diseases: the dark side of DNA repair? FEN1 POLE RAD52 XPA LIG1 OGG1 NEIL1 PMC8353504__F1 Hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders NPY CPT1A AgRP CPT1C PMC5618525__F3 Signaling events downstream of IL7R (depicted in purple) and the pre-BCR (depicted in black and red) involved in the regulation of RAG1/2 expression and Ig light chain recombination RAG1 IL7R BCL2 JAK3 MCL1 CCND3 FOXO1 PMC6263343__F3 Heme biosynthesis FECH UROD CPO PMC11048239__F4 Flux-independent signaling by NMDARs in neurons SRC NOS1AP PANX1 TRPV1 PMC3682694__F1 Roles of molecules explained in this review in signal transduction SET APC GSK3B VHL PTEN MTOR RHEB TSC2 NF1 TSC1 ATM PPA2 GRB2 PKD1 ATR PMC6274950__F10 Correlation networks of main potential biomarkers in response to T2DM rats SOCS3 CRP IL1B PMC8692454__F4 Reconstruction of the Rhodotorula frigidialcoholis major carbohydrate metabolic pathways mapped with transcriptomic data SDHC CS PC HEL-S-304 DLD XYLB RPIA OGDH SORD ACLY MDH2 SDHB PMC7794017__F1 Canonical and non-canonical WNT pathways MMP7 APC GSK3B MYC LRP5 CCND1 LRP6 ARHA RYK PMC3243790__F1 Regulation of ABCA1 Functions by Signaling Pathways IL6 TNF STAT3 PMC2855687__F1 The kynurenine pathway with relevant regulatory components, summarizing gene expression and metabolite changes previously identified for schizophrenia in the frontal and anterior cingulate cortex HAAO HEL-S-90n KYNU KMO MC5R MCHR1 TDO2 PMC4135535__F3 Challenges in Vaccination of Neonates, Infants and Young Children BCR CD22 CD40 PLCG2 PMC2607114__F1 TFPI anti-coagulant and anti-inflammatory activities TFPI CAST LYN SRC TF PMC8228391__F1 Bilirubin: A Promising Therapy for Parkinson’s Disease SNCA PINK1 LRRK2 SMPD1 SCARB2 TNF PMC5844144__F1 Ferroptosis-associated metabolic networks ME1 GPX4 LPCAT3 FACL4 ACACA IPP PMC9657658__F2 Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells NOD1 TRAF2 NOD2 PMC3048826__F12 Signaling pathway of HMGB1-mediated ischemia reperfusion injury IL10 HMGB1 TLR9 SRC RHO RAC1 TNF CDC42 PMC7408018__F1 Autophagy pathway including the convergence of the endocytic pathway ULK1 ATG16L1 ATG12 LAMP2 ATG101 MTOR ATG14 RB1CC1 PIK3R4 PMC7520643__F1 Protein kinase B signaling pathway PTEN NQO1 PMC7300250__F1 Signaling pathways regulated by Shp1 CDK2 SRC BCL2 CDK4 RAC1 CDK6 STAT3 PMC2873801__F4 Relationships between differentially expressed miRNAs, putative target genes, and functions DGIC SPRY1 NNT BATF MNT LDLR NMI OTUD4 ADM LY9 GPHN TCEAL2 ARHGDIB CLIC1 MMP10 PLK2 AMPD3 IGLL1 ALPK2 PDE4DIP ATF3 CTSH NDP LAMA1 ELF3 BCL2 GLDC ASS1 PMC7408018__F2 ER stress unfolded protein response (UPR) pathways triggering autophagy ATG16L1 ATF4 BCL2 MTOR XBP1 DDIT3 PMC6858516__F5 Towards precision oncology in advanced prostate cancer CDK2 CDK4 RB1 CDK6 PMC9636677__F6 Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC HMGB1 CCNB1 BCL2 CDC2 BAX PMC6858516__F6 Towards precision oncology in advanced prostate cancer SOX2 EZH2 RB1 AURKA PMC6978262__F1 Signaling transduction pathways of regulating autophagy ULK1 MTOR TRPM7 PMC11055934__F1 Depicts the eicosanoid inflammatory pathway COX2 PTGIS GC EPHX2 CYP4A11 PMC6858516__F3 Towards precision oncology in advanced prostate cancer FKBP5 PTEN PMC6858516__F4 Towards precision oncology in advanced prostate cancer CHEK2 ATM BRCA2 MSH6 CDK12 MSH2 ATR BRCA1 PMS2 PMC8468925__F3 Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives ATM ATR PMC6858516__F1 Towards precision oncology in advanced prostate cancer CHEK2 ATM BRCA2 CDK12 CDK4 RB1 CDK6 PMC4791795__F2 Select Biological Pathways Significantly Associated with Differentially Regulated Genes NLK EGF LTA NGF PMC11055934__F4 illustrates the various components of the p53 regulatory pathway and relevant polymorphisms associated with ISFO MMP2 WRAP53 MMP9 MDM2 TUG1 PMC2768529__F8 Proposed interplay between IL-15 and TNFA signaling in skeletal muscle TRADD IL15RA CAD TRAF2 FADD PMC4694985__F3 The respective drug targets in the overall architecture of molecular interactions for the top pathways correlating with response to Pazopanib A CREB1 PTEN EIF4E MTOR IRS1 TSC2 RET TSC1 ATM ATF4 RAD51 JUN FASN PMC11210914__F5 Mitophagy in ferroptosis PINK1 FTMT FUNDC1 PMC7744479__F2 Lymphoma induced angiogenesis in LNs and participating immune cells FGF2 MMP9 CCL21 VEGFA LTB CD44 CXCR3 VEGFC IL16 LTA CCR7 CXCL9 CCL19 ELL PMC11210914__F7 CMA- or TAX1BP1-mediated GPX4 degradation in ferroptosis GPX4 LAMP2 SLC7A11 SMPD1 MTOR HEL-S-72p HEL-S-29 PMC5217035__F7 Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling POR BAX PMC3936121__F7 MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family MUC4 RRM1 PMC3403823__F1 TLR-induced corneal inflammation TLR4 TLR9 TRAF6 IRF3 MYD88 TLR3 PMC8591223__F10 Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA ULK1 ATG12 LAMP2 RAB33B NRBF2 ULK2 HIF1A MTOR DKFZp686F0183 EIF2AK4 UVRAG STX17 RB1CC1 PMC8231924__F1 MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions RAPGEF1 AMOTL2 ESAM ARHA TRIP6 NET1 PTEN MAGI1 ACTN4 PMC2951022__F1 Toll-like receptor (TLR) signaling pathways TBK1 CD14 TLR5 IRAK1 TRAF6 IRF3 MYD88 TLR1 MAP3K7IP1 TLR4 RELA ECSIT TIRAP PMC3292584__F4 Differential gene expression in the TLR signalling pathway CD14 CHUK FOS TRAF6 LY96 MYD88 TLR3 IKBKB NFKBIA TLR7 TLR4 LBP ECSIT JUN TIRAP PMC5659172__F3 Trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase HEL-S-62p TXN PMC7968485__F1 Ferroptosis: Regulated Cell Death GPX4 LPCAT3 FACL4 ADA PMC6978262__F2 Related miRNAs and target genes/pathways that regulate autophagy BACE1 ATG12 ATG10 MTOR ATG9A DKFZp686F0183 SIRT1 PMC5630287__F6 Beta-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation NAMPT NMNAT2 CTCF NMNAT3 PMC2683584__F1 Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord FADD BAX PMC3675828__F3 Abundance distribution of cell cycle proteins RAD1 APC SKP1 POP1 PEF1 RBX1 ORC3 ORC2 MRC1 RAD17 PPA2 APC2 RAD21 PMC5876639__F1 Involvement of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) in DNA damage response pathway ATM ALK MDM2 ATR PMC7348182__F7 Results of RT‐qPCR and ELISA validation for cAMP and Rap1 signal pathway BLM ADCY1 ADCY5 ADCY8 PMC7148637__F40 RV regulation of the IFN amplification pathway STAT1 STAT2 IRF7 IRF9 IFNAR1 IFNGR1 IFNLR1 PMC8750433__F2 Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines IGF1 SMAD2 MTOR PMC4472122__F1 Signaling pathways activated by FGF/FGFR STAT1 FRS2 SRC PMC8489124__F5 Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3B/Beta-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway CYC1 APP PMC11210914__F1 Ferroptosis GPX4 AIFM2 MGST1 FACL4 SLC7A11 NFE2L2 TFRC POR DHODH PMC8798099__F4 Gene network screening of bladder cancer via modular analysis KMO BRCA2 DAP POR COMP TERT PMC11257964__F4 Targeting PANoptosis for cancer therapy NLRP3 RIPK1 RIPK3 FADD ZBP1 MLKL GSDMD DFNA5 PMC11257964__F1 Molecular machinery of apoptosis, pyroptosis, and necroptosis NLRP3 RIPK1 NLRC4 TRADD RIPK3 TRAF2 FADD MLKL GSDMD BAX PMC3011268__F2 Regulation of Wnt signaling in Xenopus CNC C6 PTK7 TRIO PMC3253010__F3 A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype SPARC ICAM2 LAMA4 KCNB1 NID1 NID2 FYN PLXND1 HSPG2 KDR NRP1 CAV2 CD93 JAM2 AKT3 ARHGDIB PMC4830852__F1 Proteins encoded by genes analyzed in this study in the inhibition of the Wnt signaling PPP2R2B DACH1 CCND1 SFRP1 DKK1 SOX17 PMC7139457__F1 Intrinsic apoptotic pathway and interactions between pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) family members BAD BIK BMF HRK BAX PMC4561407__F4 Translational control by ERK and mTOR EEF2 MTOR PMC3755409__F6 Scheme of the andrographolide regulatory pathway KDR NRP1 CCND1 PMC9437628__F4 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets CASP3 CAP2 TRADD CASP2 TNF TRAF2 FADD PMC11050296__F10 Scheme showing the mechanism of olive-derived secoiridoids that regulate melanogenesis signaling pathway DCT MC1R PMC6020395__F1 The vitamin-D metabolic pathway CYP27A1 CYP2R1 CYP24A1 CYP27B1 PMC8296701__F1 Genistein as a regulator of signaling pathways and microRNAs in different types of cancers ATM EGFR MTOR STAT3 PMC9437628__F2 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets CASP3 TRADD CASP9 CASP2 TNF TRAF2 CASP8 FADD PMC3536145__F7 GXM-mediated inhibition of LPS-induced signal IL16 TLR4 MYD88 PMC11241568__F2 The JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia STAT1 CRLF2 JAK3 JAK1 TSLP STAT3 PMC4761208__F5 Pathway network of the 22 TSGs based on GeneMANIA PLK2 APC STK4 REST PTEN FADD BAX PMC5915057__F4 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer EGF CD9 CDH11 IL12A XBP1 SOX4 SELL CSF1R JUP APAF1 PTK2B EMB PECAM1 EIF4E3 CD14 SORT1 NUAK1 DUSP4 FOS FGFR3 RRAS IL24 S1PR3 GADD45A RAC1 ITGB1 IRS1 GRB7 BCL6 PIK3C2B TIAM1 CACNA1H ITGB4 SNN PDGFC MARCKSL1 MEX3A KIAA1632 NREP TBXA2R TFAP2C PIK3R2 CDC42 PMC5915057__F5 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer IRX3 CD133 STK17B ETV6 MYC CPT2 PRIM2 CCL2 ADAM19 PRIM1 NF1 NR1i1 POLA2 ZMAT3 JUNB BTG2 GINS2 FDXR ELK3 COL18A1 FOS CENPE AURKB MCM3 CDC20 NFKB2 CYP4F3 KLF4 TGIF1 MXI1 PCNA TPM1 BLM EBP XBP1 CLU CEBPB HEL-S-2a IER3 ATF4 CCND1 JUN CCNE2 CTH WWC1 NFIB MMP16 RNF4 PBX1 ID1 DDIT3 POLD3 RFC3 SMC2 SPX TYMS HES7 BAG2 PHYH ETV5 KIFC3 ABRACL ZNF703 AGL ELL HES2 PMC6406640__F3 Schematic representation of gene silencing by siRNAs AGO2 AGO4 DROSHA PMC5690305__F1 Simplified metabolic pathway of thiopurines RAC1 TPMT TG PMC3478260__F4 signaling pathways triggered by L1CAM L1CAM HEL-S-28 SRC PMC5094313__F5 Metabolic pathways that may be affected by lactate flooding of brain after traumatic brain injury PC CIT PMC8122033__F4 CGAMP transport in the tumor microenvironment CGAS IRF3 SLC19A1 PMC8055391__F7 Follistatin-Like 1 Attenuation Suppresses Intervertebral Disc Degeneration in Mice through Interacting with TNFA and Smad Signaling Pathway TLR4 ADAMTS5 IVD FSTL1 TNF SMAD1 BMP4 PMC8616527__F3 Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease RHO RAC1 POR FRMD6 CDC42 PMC7478169__F1 Normal downstream pathway of TSC1 and TSC2, and its gene products TSC2 TSC1 RHEB MLST8 PMC9388335__F7 Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through nuclear factor KB and mitogen-activated protein kinase signaling pathway IL1B KLF7 PMC3899964__F1 Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination EREG RNF11 SULF2 MED10 LRRFIP2 OBSCN ARHGEF3 HEL-S-99n ARHGAP19 SMAD4 ARHGAP12 WAS AGGF1 MMP2 SHH SMO ROR2 EZH2 ELMO1 CDON SFRP4 TNIK FOSL1 AREG CHP2 UBE2B PLCB4 CXCL12 TGFA CDC42 WWOX PRKCE TGFBR1 EGFR GAS1 RHO TTN FZD1 CLU RRM2 SF1 FZD7 MFAP2 MED1 FRAT2 ARHGAP10 NOTCH4 NOTUM CD44 ARHA HEL-S-102 NLK GIG8 CAMLG LYN FRAT1 PTPN18 PMC6273696__F30 mTOR signaling pathway was regulated by vancomycin in HK-2 cells TSC2 TSC1 PC ELF3 EIF4E RPS6 MTOR RHD EIF4B RHEB INSR PMC3407412__F3 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles PTPRC TH CD6 CD2 APC CD22 CD40 CD80 CTLA4 SPN CD226 ICOS PMC3407412__F5 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles VASP BAD HEL-S-28 SHE ARHA PTEN PMC2547860__F6 Networks among genes involved in milk fat synthesis EPO ACACA ACSS2 OSBP PPARGC1B SPHK2 GPAM THRSP PPARGC1A SCD LPIN1 LPL SREBF2 ACSL1 XDH ABCG2 FASN SPTLC1 DGAT1 VLDLR BTN1A1 INSIG1 FADS2 FADS1 ABCA1 PMC8957998__F8 Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm TH ME1 FRY KY CS MAFK MYL1 TNF TRAF2 PMC4174766__F2 Intracellular TLR signaling and trafficking in pDCs TLR7 TLR9 IRF7 IRAK1 UNC93B1 TRAF3 TRAF6 IRAK4 MYD88 DOCK2 PMC5549971__F7 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses KAT2B NCOR1 RBBP4 HDAC1 BRCA1 SAP18 KAT2A EP300 RBBP7 KPNA2 HDAC2 NCOA1 SIN3A SIRT1 SAP30 NCOR2 PMC5686110__F2 Signaling pathway of breast cancer download from KEGG website– with targeted genes and pathways from germacrone, curdione, and furanodiene KIT APC REL PMC6365104__F1 Main regulation modes of copper transporters in human cells ATOX1 SP1 PMC6273696__F36 ER stress signaling pathway was regulated by vancomycin in HK-2 cells CASP12 ATF4 HEL-S-99n CASP9 TRAF2 XBP1 PMC6273696__F37 ERK-MAPK signaling pathway was regulated by vancomycin in HK-2 cells BAD MOS NFATC1 MYC GRB2 SRC DOCK1 EIF4E CRK PXN ARAF PMC5549971__F4 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses EGF FOS VCAN TPR ATF3 ARHA TRPS1 MTOR HPGD PLAT NR1i1 NKX2-1 HEL-S-2 RELA GHR XDH JUN NFYA LAMC2 PMC6273696__F34 Remodeling of epithelial adherent junction signaling pathway was regulated by vancomycin in HK-2 cells HGF APC HGS RALA PMC6273696__F35 UPR signaling pathway was regulated by vancomycin in HK-2 cells SEL1L CANX OS9 AMFR ATF4 BCL2 VCP TRAF2 XBP1 PMC6273696__F33 Tight junction signaling pathway was regulated by vancomycin in HK-2 cells INA SAFB STX4A CASK PTEN HEL114 TNF CGN RAB13 PMC10520362__F3 Mammalian Intestinal Development and Differentiation—The State of the Art RSPO3 DKK3 FOXL1 BMP5 GPR49 WNT2B PMC5541263__F8 Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway RARB NUMB RXRA TET2 PMC6284756__F9 Regulatory effects of miR-1292 on hADSC senescence and osteoblastic differentiation LEF1 APC LRP5 LRP6 FRAT1 PMC5701012__F7 PD-L1 upregulation in response to DNA double-strand breaks STAT1 ATM BRCA2 RAD51 ATR IRF-1 STAT3 PMC2743272__F1 Mechanisms underlying the pleiotropic effects of statins in stroke BMP2 ARHA RAC1 CDC42 PMC6388629__F6 IPA network map depicting the DR signaling changes in HBEpCs after 6 h of infection with IAV H1N1 TBK1 TANK REN TRADD CASP2 DIABLO GAS2 TNFSF10 MAP10 BCL2 TNFSF12 SPTAN1 FADD CYCS ARHGDIB PMC7006459__F1 Fyn activates divergent signaling cascades in effector lymphocytes FYN BCL10 LCK PTEN LAT PMC6388629__F5 Ingenuity Pathway Analysis (IPA) network map depicting the DR signaling changes in HBEpCs after 2 h of infection with IAV H1N1 TBK1 LIMK1 TANK TRADD CASP2 DIABLO TNFRSF1B TNFSF10 MAP10 BCL2 TNFSF12 SPTAN1 CRADD ARHGDIB PMC6962108__F1 Mechano-sensing by LSECs drives fibrotic processes YAP1 PIEZO1 HES1 PMC2588608__F2 Pathway Annotation and Summary Hit Table HP ACAN DDT PMC12229552__F9 Schematic diagram illustrating the mechanism by which DDX1 lysine methylation mediates MATR3 alternative splicing to regulate IVDD ME1 NPS DDX1 EZH2 PMC4731263__F3 Mapping Proteome-Wide Interactions of Reactive Chemicals Using Chemoproteomic Platforms BAT5 PMC10486522__F1 Leptin and a schematic representation of leptin-induced signaling pathways SOCS3 MTOR IRS1 STAT3 CAMKK2 PMC10486522__F2 Adiponectin and a schematic representation of adiponectin-induced signaling pathways SOCS3 APPL2 MTOR IRS1 SIRT1 STAT3 APPL1 PMC3327653__F1 Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway GPAT4 PC LPA PMC6329310__F2 Role Of Atm In Ebv Life Cycle Regulation (A) The central role of ATM in the replication compartment of EBV ATM MYC RAD52 RAD51 BMI1 SP1 PMC6273696__F29 PI3K/Akt signaling pathway was regulated by vancomycin in HK-2 cells TSC2 BAD TSC1 HEL-S-28 MDM2 GRB2 CCND1 CDC37 PTEN EIF4E RHEB PMC8198784__F3 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis AHR VCAM1 CIC PMC6273696__F27 G2/M DNA damage check point signaling pathway was regulated by vancomycin in HK-2 cells HIPK2 RPRM DKFZp781B1423 CHEK1 AURKA TRIP12 WEE1 ATM PPM1D MDM2 ATR C13orf34 MYT1 PMC6273696__F28 Apoptosis signaling pathway was regulated by vancomycin in HK-2 cells APAF1 ROCK1 MCL1 CAD TNF DIABLO HTRA2 BIRC6 CYCS GAS2 BAX PMC8198784__F1 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis IDO1 HEL-S-90n KMO IDO2 TDO2 PMC6484083__F2 The inferred and enriched PPI network from 43 genes that sensitize yeast to Mn when deleted LIPE POLL PMC8198784__F5 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis MTOR STAT3 PMC6580320__F1 unctions and subsequent pathways of eukaryotic initiation factor 5A2 in human digestive system neoplasms EIF5A2 ACSS2 RHO FASN PMC3628365__F9 Speculative model of TERRA, hnRNP A1, and hTR/DNA-PKcs interactions at telomeres SMG1 PMC8939789__F7 Integrated model of potential mechanisms of HIV transcription and latency modulation by Beta-catenin PMC8475157__F1 Abnormalities in the signaling pathway that exacerbate type I IFN responses STAT1 STAT2 IRF7 IRF8 IRF9 STAT4 TYK2 JAK1 IRF-1 PMC11204236__F11 Proposed model illustrating the network of molecular mechanisms governed by miR-1 during early differentiation of the cardiac sinoatrial region NCOR1 TBX5 MED1 MEF2C GATA4 CALM1 PMC6525084__F3 RNA-seq identifies synergistic (GxE) genes, which are enriched in NF-kB signaling pathway TBP LCK TRAF2 PMC9662161__F5 Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells RBM10 CCND1 CDH2 TNF PMC10977403__F2 Dependence receptors have two properties: when the ligand is present, binding to the ligand promotes cell survival, migration or differentiation MTOR JUN HEL-S-69p PMC5383785__F5 Depiction of RAS-ERK signaling pathway and primary and secondary connections to substrates identified by time-resolved phosphoproteome profiling EGF BAD FLNA EGFR NUP188 TPR ERF AHNAK RHO FLNB TCF12 HSF1 RANBP2 RPTOR TP53BP1 TEAD3 RPS6 NUP107 FOXK2 TAF6 TRIOBP NCOR2 TRIO GIGYF2 TP53BP2 ETV3 FOXP4 CNOT4 GIGYF1 YAP1 CNKSR1 CNOT2 NUP214 MAP2K2 TBC1D4 IRS1 MCAT NUP153 PAK1 ERBB2 JUND RAF1 GRB10 SOS1 PXN LMO7 STAT3 PMC4741654__F1 The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents FH CHDH DHFR PMC2395337__F1 5-Fuorouracil drug pathway demonstrating the interaction of multiple gene products GGH DPYD DPYS UMPS NME2 UNG FPGS TK1 RRM1 RRM2 NFKB1 FH DHFR TYMS DUT FDXR PMC5039188__F1 TLR signaling overview TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 PMC7039202__F1 Modular composition of the SGOCP SHMT1 SFXN1 MTHFD1 MTHFD2 PHGDH HEL-S-68p HEL-S-61p MTR PSAT1 DHFR PSPH HEL-S-51e MTHFD1L PMC7039202__F2 Sources of one-carbon units UROC1 HAL SHMT1 AOC2 FTCD NAT1 ADH5 MTHFD1 MTHFD2 TDO2 AFMID GLDC HEL-S-51e MTHFD1L PMC7039202__F3 Products of the SGOCP SPTLC1 HEL-S-182mP SHMT1 NNMT AMD1 MTHFD2 PEMT MAT1A SRM DHFR HEL-S-51e ARG1 SMS MTHFD1L PMC8753976__F3 Signal transduction mechanism of exosomes in diabetic complications (Review) IGF1 SMAD2 ETS2 PMC7039202__F4 Regulation of the SGOCP TSC2 TSC1 ATF4 EIF2A KDM4C PMC8753976__F4 Signal transduction mechanism of exosomes in diabetic complications (Review) NUMB TLR4 PMC9103730__F1 Abiotic Stresses in Plants and Their Markers: A Practice View of Plant Stress Responses and Programmed Cell Death Mechanisms CD2 ERF PMC4005613__F1 Molecular Pathways: Co-Expression of Immune Checkpoint Molecules: Signaling Pathways and Implications for Cancer Immunotherapy APC LCK ZAP70 CD160 CD48 BTLA CTLA4 LAG3 MTOR PMC8200641__F2 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis ATF4 EIF2A XBP1 PMC9661468__F4 Stress during mitosis activates apoptosis and inflammation CGAS MDM2 IRF3 PMC8301761__F1 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer CXCR1 HGF KDR IL8RB PMC7051019__F2 a) Signaling pathways and transcription regulation of adipogenesis SIRT2 IGF1 EBP INS SIRT1 PMC8301761__F2 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer TSC2 PI3 TSC1 PTEN INPP4B RHEB PMC8301761__F4 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer APC GSK3B LRP5 LRP6 TNKS PMC7802449__F4 Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease IGF1R ECD TSHR PMC8249129__F8 Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study HEL-S-11 GSK3B MYC SRC BCL2 MTOR PMC6378304__F5 Strategies to overcome NK resistance in solid tumors CXCR3 CXCL1 MICB CXCL10 EGFR CXCL8 IL8RB MICA CCL5 TIGIT PMC5081350__F1 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 TNKS BCL9 PMC6639976__F5 CXCL13 in prostate cancer CXCL13 CXCR5 PTEN PMC11206888__F7 Diagram of PI3K–AKT signaling pathway BAD CD37 MEI1 MYC PTEN EIF4E MTOR IRS1 TSC2 MDM2 GAL RBL2 CD19 PMC5081350__F3 Wnt/Beta-catenin signaling therapeutic targets GSK3B TNKS BCL9 PMC2737270__F1 Autophagy pathway and machinery.A ATG12 ATG3 ALG12 ALG5 ATG10 PMC5325695__F1 Emerging roles of p53 and other tumour-suppressor genes in immune regulation TBK1 TLR9 STAT2 IRF7 IRAK1 IRF9 IFNE TRAF6 IRAK4 IRF3 IFNAR2 IFNAR1 TLR3 STAT1 ISG15 TLR8 TLR7 BAX PMC8200641__F4 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis EIF2A SEC63 PMC8219969__F1 Promising Future of Ferroptosis in Tumor Therapy GPX4 SLC7A11 ATF4 TFRC SLC3A2 PMC1817784__F2 Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders TSC2 EEF2K TSC1 MTOR RHEB PMC6861747__F17 Antidepressant-like effects and mechanisms of GXDSF via mediation of the CaMKII-CREB-BDNF signalling pathway in chronic unpredictable mild stress (CUMS)-induced depressive rats FST NGF BDNF PMC5462960__F7 Location of BHP biosynthetic genes and gene clusters in the genomes of SD1, SD3, and SD4 Acidobacteria and a number of selected environmental genomes as determined by BLAST protein searches MVD SHE MVK HMGCR PMC9381850__F7 Comprehensive Analysis of Interferon Regulatory Factor Expression: Correlation with Immune Cell Infiltration and Patient Prognosis in Endometrial Carcinoma EDAR DAP MIP HEL-S-70p FADD PMC9300693__F7 Proposed mechanism by which thiostrepton modulates ferroptosis via the STAT3/GPX4 signalling pathway GPX4 SLC7A11 HEL-75 STAT3 PMC2935989__F3 GRK2 interactome involved in the modulation of cell cycle progression PIN1 FOXM1 CDK2 SMO CDC2 ADRBK1 PMC7588972__F1 Pivotal role of Mediator complex in the ABA signaling pathway MED25 CDK8 MED18 PMC2935989__F2 GRK2 interactome involved in cell migration CCR5 RGS4 SMAD2 APC CCR4 RALA RGS2 IRS1 TLR3 KCNJ3 TLR7 TLR4 PAWR CXCR4 MDM2 GRB2 SRC ADRBK1 PMC3102695__F5 Ciliary Neurotrophic Factor Induces Genes Associated with Inflammation and Gliosis in the Retina: A Gene Profiling Study of Flow-Sorted, Müller Cells UBTF LETMD1 GFAP KLF2 CEBPA ARHGEF11 STAT3 PMC7588972__F2 Simplified network of TFs and Mediator complex in regulating the abiotic stress responses MED25 MED14 MED16 CDK8 PMC8973533__F5 Carbohydrate regulation response to cold during rhizome bud dormancy release in Polygonatum kingianum ME2 STS GAL PMC11024860__F9 Working Model: HDAC6 maintains primordial follicle dormancy TSC2 NGF BDNF TF PMC3791614__F1 The interactions between the control of the cell cycle and the expression of specific ligands for activating NK receptors in various pathologies RAE1 CDK2 CDK4 ATR PCNA PMC9105874__F1 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors NLRP3 RIPK1 IL18 RIPK3 CASP8 IL1B TRPM7 FADD MLKL GSDMD PMC9105874__F2 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors PLCG1 IL18 TRPV2 TRPM2 IL1B GSDMD PMC6874533__F9 Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells HOXA11 CCND1 NKD1 PMC3249073__F1 PtdEtn synthesis pathways in Plasmodium and yeast MME PSD PMC2666844__F3 In the absence of Wnt stimulation, the APC (adenomatous polyposis coli) forms a trimeric complex, known as the “destruction complex,” with glycogen synthase kinase-3B (GSK) and Axin COX2 APC AXIN1 AXIN2 PMC2666844__F5 Simplified schematic of hepatocyte growth factor (HGF)/MET signaling pathway HGF GRB2 PMC7693344__F1 Metabolic enzymes associated with glycolysis and the pentose phosphate pathway, depicted here, serve as critical regulators of inflammatory responses in myeloid and lymphoid cells HEL-S-30 MYC MTOR PMC2666844__F6 Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGFA/EGFR) EGFR GRB2 TGFA PMC8323674__F1 Research trends, hot spots and prospects for necroptosis in the field of neuroscience TLR4 CRIP3 TNF TLR3 MLKL PMC12245917__F1 Molecular signal pathways related to H MMP10 CGAS MMP9 APC LRP5 RELB LRP6 TRAF6 IRF3 LATS1 MMP3 CDX2 TIFA CDC2 TRAF2 TAB3 PMC12245917__F2 Crosstalk among H YAP1 PMC5802806__F5 Proposed mechanism C7 PMC6343143__F2 Proposed model of estrogen-induced ROS generation increase in thyrocyte SSB NOX4 TPO PMC1782589__F2 Signalling cascades of the LPS pathway and reported sites of IL-10 intervention CD14 MAPKAPK2 LYN GSK3B RAF1 PMC11635231__F2 Importance of FXR in the enterohepatic circulation of BAs CYP27A1 GCA CYP8B1 HNF4A ABCG8 ABCG5 FGF19 CYP7B1 FGFR4 BAAT CYP7A1 PMC11635231__F3 FXR in four lung diseases EGF SNAI1 IL18 GCLC EGFR ARL11 SNAI2 IL6ST TNF NQO1 STAT3 PMC7082402__F1 Red blood cell—inflammation vicious circle in sickle cell disease NLRP3 TLR4 IL1B PMC9552847__F7 PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradation FBP1 PTEN SKP2 PMC3248767__F2 Bevacizumab Treatment for Advanced Breast Cancer EGF HGF TGFA PMC11577950__F7 Metabolic pathway diagram of lysosome and autophagy pathways of DEGs after knockdown of HlDnmt1 and HlDnmt in Haemaphysalis longicornis GNS SGSH GM2A HEXA GALNS NAGA ABCA2 GAA GUSB AGA LIPA HGSNAT ABCB9 LITAF ACP5 CLN3 ACP2 IDUA GLA PMC2888475__F1 Cellular apoptosis pathways and intervention by both cellular anti-apoptotic proteins and viral proteins encoded by oncolytic Ad, HSV and VV CASP9 BCL2 FADD PMC9380140__F7 Upregulation of RCAN1.4 by HIF1A alleviates OGD‐induced inflammatory response in astrocytes COX2 IL18 IL6 HIF1A PMC8213017__F1 Modulation of Ferroptosis and Its Role in Central Nervous System Diseases GPX4 LPCAT3 FACL4 SLC7A11 ADA SLC3A2 IPP TF PMC3401974__F2 Mammalian target of rapamycin (mTOR) pathway regulates T-cell activation, differentiation and migration APC CCR7 MTOR PMC11726960__F2 Key characteristics of models used to recreate cardiac systems in vitro and relevant signaling pathways IGF1 APC LRP5 LRP6 SHF BMP4 PMC3055312__F1 Signaling pathways regulating GSK3 and functions of GSK3 related to mood regulation DISC1 LRP5 LRP6 BDNF TF PMC6713350__F5 Bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells CDK17 PLCB3 CD248 F2R SPON2 ADAM15 SOST STK40 SNAI2 CD300A CD74 NRP2 CDK6 BMP4 RARA STS ARPC1B AXL MGP GPC3 DOCK6 HEL-S-31 TLR3 NID2 TSHB TNC AGER CCNB2 CXCL12 SBNO2 VEGFB LBH MYLK SGCB MLKL WHR1 PMC10484938__F7 Metabolic remodeling in the brain and liver following STF HEL-S-61p MTR FOLH1 RIMKLA RIMKLB GPT2 CIT ASS1 ASL PMC6182269__F1 Cell intrinsic dysregulation of innate immune signaling in MDS HSCs CD14 TIFAB IRAK1 IRAK2 TRAF6 IL1R1 IRAK4 IL6 MYD88 NLRP3 IL18 IL16 RELA IL1B TIRAP PMC8074054__F1 Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together IL16 IGF1 TNF PMC6460856__F3 MyD88 played a critical role in alveolar macrophage-mediated inflammatory response to CNTs TRAF6 MYD88 IL1B PMC4570544__F1 The Clp proteases and chaperones in Plasmodium and the Plasmodium translocon of exported proteins CIPC CSA2 CLPP PMC5876639__F2 Cellular senescence pathway activated by NPM-ALK ALK CDK4 CDK6 STAT3 PMC11890630__F8 Progressive accumulation of transcriptional alterations during the progression of T2D reduces adipocyte thermogenic capacity TRPV4 PDE3A C1orf51 HDAC11 RORB LRPPRC PTEN PACS1 ASF1A NLRP3 NPR3 PPARGC1A PER2 BAX BAK1 DIABLO PLN EDNRA MAX RELA RYR1 RYR3 CASQ2 CIDEA SIRT1 PMC5187684__F1 A schematic of metabolic intermediate labeling from 13C glutamine HEL-S-26 NNT PMC8240065__F4 Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles IRAK1 CD48 TRAF6 IRAK4 CXCL2 CCL7 CCL5 CCL2 MYD88 CR1 SNAP23 TLR4 LYN CR2 IL1B PMC6460856__F2 Mechanisms by which carbon-based nanoparticles induce cytotoxicity of macrophages NLRP3 IL16 PMC9710325__F2 Perspectives on Challenges in Cannabis Drug Delivery Systems: Where Are We? COX2 BAD ATF4 TRIB3 SRC ARHA PMC8340019__F4 Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade MAPK4 MYC ERF PMC10977574__F8 Compound-key target-core pathway BRAF REN PGR ALK FLT4 DPP4 ACHE CCKAR TRPV1 BTK MMP2 ATM NGFR FURIN CHRM2 PBR SNCA c-fgr PDGFRA VEGFA CDK5 FGFR3 PIGS CTSH TNF HEL-S-130P NR1C1 NRK RET EDNRA OXTR CXCR4 CTSC LCK NR1C2 JAK3 MYLK AKT3 PMC2868837__F3 Major gene products affected by virulent infection VEGFC EGR1 IL1A EGR2 FOS PTGS2 EGFR IL1RL1 VEGFA JUN IL1B PMC7281398__F5 Summary of Gene Ontology Analysis and Pathway analysis on genes that are associated with ex vivo VP16 response, ranked according to adjusted p-values RMI2 UNG BYSL MTFR2 HMMR POLE HLTF CKAP2 ZWINT GMNN PCNA CENPA FANCG PMC7409324__F2 NFkB-induced expression of MHC-I RELA RELB TRAF6 TRAF2 PMC10977574__F9 Core-compound-core key target-core pathway PIK3R1 ALK EGFR MAPK3 MTOR MMP3 KDR MMP2 F2 PTPN11 MDM2 SRC PTGS2 MMP9 IL6 TNF HDAC1 HMGCR NFKBIA CDK2 LCK PIK3CA BCL2 JAK1 PPARG TERT PMC6357155__F2 The life cycle of SARS-CoV and MERS-CoV in host cells DPP4 ACE2 HEL-S-69p PMC7409324__F3 Interferon (IFN)-induced expression of MHC-I STAT2 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IRF-1 IFNG STAT3 PMC7409324__F4 Therapeutic interference to boost MHC-I antigen presentation of tumors PIN1 STAT2 IRF9 EGFR RNF2 IRF3 SMURF1 DUX4 IFNG STAT1 N4BP1 CYLD PTPN1 RELA PTPN11 JAK1 IRF-1 STAT3 ITCH PMC8517994__F2 MiRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer ATG9B EIF2A XBP1 PMC10938947__F2 Introduction of pathways related to bone regeneration, like WNT signaling pathway APC MSC LRP5 LRP6 PMC7555571__F1 AHR signaling pathway AIP AHRR AHR CYP1B1 SRC PMC8651533__F2 Proline metabolism and redox; maintaining a balance in health and disease PYCR2 PRODH ALDH18A1 PMC9199231__F1 Interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms NLK ACTL6A VGLL4 AJUBA RHO PMC10938947__F3 Introduction of pathways related to bone regeneration, like Hedgehog signaling pathway, Notch signaling pathway and FGF signaling pathway IHH FRS2 DLL4 MSC JAG2 GRB2 SMO DLL3 PMC10938947__F4 Introduction of pathways related to bone regeneration, like BMP/TGFBsignaling pathway SMAD2 MSC SMAD6 SMAD4 MAP3K7IP1 SMAD1 DKFZp781O1323 PMC5816931__F2 Recognition of Mycobacterium tuberculosis (Mtb) by Dectin-1 CARD9 BCL10 APC SYK TNF PMC7291661__F2 Proinflammatory cytokines regulating keratinocytes or stem cells TRAF4 STAT3 PMC10977574__F7 Core pathway of AP intervened by SHG (PI3K-Akt signaling pathway) BAD MDM2 GRB2 RAC1 IRS1 RXRA PMC4377297__F1 The role of trophoblastic microRNAs in placental viral infection AGO2 DROSHA PMC7465511__F2 MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment EPOR RUNX1 MEIS1 TPO JARID2 MTOR tal-1 SOX4 TET2 GATA1 HEL-S-26 U2AF1 ZRSR2 BCL2 ME3 MPL BAP1 BRD4 PMC8277214__F1 Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study CERS3 LASS1 DES CERS5 KDSR CERS2 CERS6 PMC6742404__F1 Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison MOBP LAT2 MBP KLF9 NR1A2 THRA PMC5696170__F7 Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells RELA CD44 CD74 PMC7528551__F2 Phosphatidylcholines constitute a major metabolic signature of VAT versus SAT CHKA CEPT1 CHPT1 PEMT PMC6949682__F5 Canonical pathway; (b) heat map of the genes related to the colitis signaling pathway in colonic epithelial cells obtained from wild-type (WT) and Slc5a8-null (KO) mice fed the fiber-free diet (FF-diet) TDG C1orf51 VIP C9 GPR173 KISS1R SLC13A1 KRT13 CMA1 DEFA3 NOS2 VNN1 DPPA3 GNRH1 PTPN5 CD3E F2RL2 CD3D HSD3B1 STXBP1 NR1C1 HLA-A TBX21 CYP2C9 MAX INHA PMC3636710__F9 LBP/CD14-independent activation of host cells by E·albumin CD14 TLR4 LBP PMC7547598__F6 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages CDKN2D CDKN2C TRIM21 RAG1 CSF3R MYC UNG SPN FCER1G POLE TAP2 MARCO CAMK4 CD2 AMPH LRRC4 SHD HEL70 MYBL2 LIMK1 ITGB3 DNTT TUBB CD5 IL20RB VAV1 CCR4 IFNAR2 PRKD2 RAG2 NFATC3 HLA-DOA PTPRC TNC THBS2 CXCR4 GRAP2 ORC1L SYK LAT HEL-S-81p RASAL3 ELL PMC7547598__F8 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages CD48 CTLA4 CBL ITK FYN BCL10 LCK ZAP70 GRB2 CDK4 IL4 LAT ICOS PMC10816220__F1 Transforming growth factor B (TGFB) and bone morphogenetic proteins (BMP) signaling pathway SMAD2 SMURF2 SMAD6 SMAD4 ARHA MTOR SMAD1 DKFZp781O1323 PMC6769118__F9 Anti-autophagic and anti-apoptotic pathway activated in human DCs by P ULK1 TLR1 PMC7090203__F3 Physical activity alters circulating monocyte features and obese adipose tissue macrophage distinction STAT1 CD14 CCR5 CCR2 TLR4 KLF4 IRF3 CCL2 IRF4 IFNG PMC7090203__F2 LPS transferring pathway and modulation of TLR4 signaling cascade CD14 TLR4 TRAF3 LBP TRAF6 IRF3 MYD88 TIRAP PMC6704489__F3 Gene category of the NFKB signaling pathway PLCG1 NGF TRADD DAO TRIM21 TRAF3 TRAF6 MIP BTK BCR ATM BASH IL1B CD14 TRIM2 LTB CNTF LTA BIK LCK LBP LYN SYK TRAF2 LTBR LAT TIRAP PMC3671299__F2 Schematic diagram of AB accumulation mechanism BACE1 MYOCD EIF2A SREBF2 ACHE PMC5424863__F2 Pathway hyperactivation defined by alterations of the PI3K/AKT/mTOR pathway TSC2 TSC1 PTEN RHEB PMC3887202__F1 De novo synthesis of steroids, oxysterols, and bile acids from cholesterol CYP27A1 CYP8B1 CYP11A1 CYP7B1 CYP17A1 PBR STAR CYP11B2 PMC6713396__F4 Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India NF1 AHRR AHR NR3A2 OGT NR0B2 NR2F1 NEDD8 TNF CYP1A2 BAX PMC9274491__F8 RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma TIAM1 YAP1 PMC3903278__F8 Cofilin regulating actin dynamics and initiating HSV-1 entry LIMK1 ROCK1 EGFR RHO PMC8067275__F1 MicroRNAs that regulate the core components of Hippo signaling pathway NF2 AREG VGLL4 LATS1 LATS2 PMC5115734__F1 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement FECH UROD UROS CPOX PMC3576027__F2 Activity-dependent neuronal signalling and autism spectrum disorder TSC2 UBE3A TSC1 ARC MTOR BDNF PMC3576027__F3 Activity-dependent neuronal signalling and autism spectrum disorder UBE3A CARF ARC NPAS4 BDNF PMC3561559__F9 Schematic model of autoregulation of BMI1 APC BMI1 PMC2684140__F9 Schematic representation of the S MOB2 CDC2 ACE2 PMC8811422__F19 Chinese Herbal Formula Ruyan Neixiao Cream Inhibits Angiogenesis of Precancerous Breast Lesions via Regulation of Ras/Raf/MEK/ERK Signaling Pathway RECK TIMP3 HRAS PMC4238427__F4 Ingenuity pathway analysis of top differentially affected pathways from the microarray data TRIM2 GAPVD1 GMFB KLF2 PMC5925761__F1 One-carbon metabolism (1-CM) and pentose phosphate pathway (PPP) at the cross-road between anabolism and redox balance TIGAR ATF4 MYC PSPH MTHFD2 PHGDH PMC6780043__F4 Effects of nanomaterials (NMs) on Ca2+ channels located on the cell membrane and Ca2+ stores and subsequent dysfunction of ion homeostasis MTOR STIM1 PMC6894260__F1 Wnt/Beta-catenin signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 DKK1 PMC8160634__F4 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity MEI1 ATM HDAC2 HUWE1 PMC10610204__F4 Activation of DNA damage-induced checkpoint signaling pathway in ATM-deficient cells and mechanism of ATR inhibitor and ATM defect-induced synthesis and lethality (by Figdraw) ATM ATRIP ATR PMC10610204__F5 WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw) WEE1 ATM CDK2 SSB CDC2 ATR PMC7148120__F3 Microglial activation on metabolism CX3CR1 CX3CL1 IFNG PMC5735682__F9 Hypothetical illustration for the role of CWP APC GSK3B PMC8160634__F2 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity CDC6 TOPBP1 HUWE1 ATR PMC5821468__F5 Severe congenital neutropenias RAB27A WAS VPS13B HAX1 SBDS GATA2 AK2 JAGN1 G6PC3 CXCR4 LYST GFI1 AP3B1 PMC8712645__F1 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy TBK1 CGAS CARD9 RAD50 IRF3 MRE11A BRCA1 MAVS IFI16 PMC8712645__F4 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy CGAS CTLA4 PMC5450843__F10 A model for transcriptional regulation of RGC differentiation DLX2 VSX2 DLX1 ISL1 PMC4097318__F1A Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis PNPLA3 CCL2 TNF PMC3079800__F1 Parenteral Nutrition Impairs Lymphotoxin B Receptor Signaling via NF- KB IL10 IL16 CCL20 RELB CCL19 CCL25 LTBR MADCAM1 PMC9105027__F1 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis SMAD2 EGFR SMAD4 HBEGF PRG4 TGFA PMC9105027__F2 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis MMP3 ADAMTS4 ADAMTS5 APC MMP9 LRP5 LRP6 PRG4 PMC5655361__F2 Signaling networks in aging TSC2 KRI1 TSC1 SGK1 PMC3072066__F5 Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state NKX2-2 FGF2 SHH OLIG2 PMC3294166__F8 KEGG pathway mapping overlay for acidic pHe upregulated genes pertinent to OXPHOS ND6 COX3 ND3 SI ND2 CYB SDHD PMC2254485__F5 Tumour growth and metastasis: Role of NPP2-catalyzed reactions WNT1 LPA PMC9612825__F1 Metabolic network ME1 CS GOT2 PIR GPT CIT RPE GAA HEL-S-32 MDH2 MAL HEL-S-162eP PMC8308226__F1 MiR-155 in Nutrition: Modulating Cancer-Associated Inflammation VHL SMAD4 ARHA IL6 JAK1 SOCS1 STAT3 PMC5354660__F5 Cycling hypoxia affects cell invasion and proliferation through regulation of claudins SUV39H1 DHFR CDK4 CDK6 PMC7796621__F7 Schematic model of the anti-inflammatory effects of hMuSCs on DSS-induced IBD AHR TNF PMC7555602__F3 Impact of redox imbalance on canonical pathway of miRNAs biogenesis GSK3B DROSHA RAN PMC3901115__F2 Autophagy pathway: Molecular features ATG12 AMBRA1 MTOR PMC2410042__F2 Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival NDN TFPI TGFBR1 PTEN CSF1R RRP1B PI16 SIPA1 TXNIP EZH2 TGFBR3 CSF1 TGFB1 SAP30 BRD4 PMC3784161__F1 AKT-mammalian target of rapapmycin (mTOR) signalling pathway TSC2 TSC1 GSK3B SRC PTEN IRS1 FOXO1 RHEB PMC3784161__F2 AKT controls T-cell differentiation RICTOR APC MTOR RHEB PMC4735774__F9 Schematic working model for presumed mechanisms underlying the effects of Mus81 knockdown on hepatocellular carcinoma (HCC) cells in response to chemotherapeutic drugs CDK2 PMC9139752__F1 Can Schlafen 11 Help to Stratify Ovarian Cancer Patients Treated with DNA-Damaging Agents? SLFN11 EZH2 ATR PMC7584116__F2 T cell metabolism by SOCE and Ca2+ signaling MYC HEL-S-87p HIF1A NR1C1 STIM2 CAMK4 ACADVL SLC2A3 PGC PANX1 IRF4 ORAI1 HK2 STIM1 CAMKK2 PMC6461560__F4 Phosphosites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT-mTOR signaling pathway in H3255 (left panel) and H1975 (right panel) RPS6KB1 EGF RICTOR GRB2 EIF4E MTOR EIF4G1 RPTOR PMC7584116__F1 Ca2+ regulates metabolic pathways at different stages of the T cell life cycle APC CD80 PANX1 CAMKK2 PMC9206313__F2 RCAN1-mediated calcineurin inhibition as a target for cancer therapy IGF1R IGF1 GC VEGFA CXCL8 NFE2L3 IL8RB IL11 RCAN1 PROKR1 PMC9095921__F1 Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke GIP RHO CCL3 PMC1526532__F1 Genomic Analysis of the Opi− Phenotype PC PSD2 MME PMC8423581__F3 Exosome: Function and Application in Inflammatory Bone Diseases TRAF5 SRC TRAF6 PTEN TNF TRAF2 PMC8423581__F4 Exosome: Function and Application in Inflammatory Bone Diseases RUNX2 LRP4 ATF4 APC SOST LRP5 LRP6 PMC10750275__F1 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer NF2 LATS1 RHO LATS2 PMC6590390__F1 Wnt, Beta-catenin. and PCP signaling APC ARHA RAC1 JUN PMC4057899__F8 Schematic diagram EGF OXTR EGFR OXT IL1B PMC5143481__F2 TLR4 signaling mechanisms CD14 TLR4 MYD88 IL1B TIRAP PMC8423581__F2 Exosome: Function and Application in Inflammatory Bone Diseases RELA RELB TRAF6 IRAK4 MYD88 CSA2 PMC5903700__F6 Schematic diagram summarising the biological processes underlying the association of the 35‐gene expression signature with PTEN/AKT signalling pathways ACTG2 HEL-S-273 PTEN MTOR TPT1 PMC9039621__F1 Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis TH CS C4B_2 C6 FCN1 PMC9189314__F2 Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis TXNIP IL1B GSDMD PMC10137108__F1 Contribution of various long non-coding RNAs and microRNAs in osteogenic pathways RUNX2 APC SMURF2 LRP5 LRP6 DLX5 MAP3K7IP1 SMURF1 PMC10137108__F2 Bone formation by miRNAs RUNX2 SOST PMC11602477__F1 Wnt/Beta-catenin pathway in CSCs APC RHO PMC10137108__F3 Long non-coding RNA that regulates osteosarcoma invasion and metastasis FGFR3 PMC11602477__F2 Notch signaling pathway in CSCs (By Figdraw) NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC11602477__F3 Hedgehog signaling pathway in CSCs SUFU PTCH1 SHH SMO PMC6345911__F7 Postulated mechanism for ceramide dependent regulation of G-CSF signaling in BMCs LYN IL8RB CXCL2 CERS2 STAT3 PMC10750275__F7 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer HMGB1 SKIL PTEN DKFZp686F0183 PMC10151765__F2 Generation, activation, and polarization of monocyte-derived macrophages in human malignancies FYN PARP1 FADD PMC6330281__F2 Wnt signaling cascades APC SOST GSK3B LRP5 LRP6 PMC4248054__F1 Mechanism of oestrogen action EGFR SRC HBEGF PMC7015151__F1 Outline of T-cell development and T-cell gene regulatory network RORC MYB KIT RUNX1 HOXA9 ATL1-beta ERG RAG1 MEIS1 TCF12 RAG2 HES1 LEF1 IKZF1 SPI1 LYL1 GFI1 MEF2C LMO2 GATA3 GFI1B HHEX PMC3062054__F4 Roles for Growth Factors in Cancer Progression KIT BCR EGFR PMC3062054__F2 Roles for Growth Factors in Cancer Progression BAD FOS SMAD2 MYC SMAD6 SMAD4 ERF PTEN PMC8075259__F2 Anaplasmataceae: Dichotomous Autophagic Interplay for Infection TSC2 ETF1 TSC1 TFEB SQSTM1 GSK3B PTEN ATG14 DKFZp686F0183 RHEB PMC8396570__F1 Putative Role of Vitamin D for COVID-19 Vaccination TBK1 TLR9 IRF7 TRAF6 IRAK4 CCL7 IRF3 CCL2 TLR3 NLRP3 TLR7 TLR4 SYK PMC8134850__F7 Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NFKB and TGFB1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling TIMP1 MMP2 KEAP1 SMAD2 MMP9 SMAD4 TNF NQO1 PMC3556981__F5 Analysis of Central Metabolic Pathway Gene Expression with Compartmentalization Information.Heat maps in boxes indicate the expression of individual genes, and the chart plots indicate the aggregate expression levels of the pathway genes CS FH PMC9254496__F1 Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways MVK IPP DMD PMC3767923__F6 Schematic of DNA damage response to double strand breaks XRCC5 NHEJ1 ATM PRKDC PNKP PMC8398289__F3 Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells RAB27A DCT MAP3K12 ATP2B1 PMC3177306__F2 The canonical vertebrate Wnt signaling pathway HIPK2 APC LRP5 LRP6 DKK1 PMC1774601__F2 Death receptor mediated (extrinsic) pathway of apoptosis TRADD FADD PMC6036444__F1 Schematic of one-carbon metabolism SHMT1 DHFR MTHFD1 HEL-S-51e MTHFD2 AMT MTHFD1L PMC2970711__F7 Scheme of cross-talk interactions between TIM-3, Gal-9 and TLR4 signaling networks CXCL1 TLR4 CXCL12 IL1B PMC9157498__F2 Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy STAT1 CD40 CD80 EIF4E PMC7419046__F2 TGF‐B signaling regulates lncRNA expression and mechanisms of TGF‐B signaling control by lncRNAs SMAD2 SMAD4 TUG1 PMC5450629__F8 Tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas IGF1R IGF1 IL4 PMC4063317__F5 Receptors and cellular signaling pathways implicated in the antitumor effect of ANP CORIN GSK3B STAT3 PMC4227274__F9 Cellular defense mechanisms induced by IPNV infection in CHSE-214 cells STAT1 BAD TLR3 PMC6245951__F7 Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-Beta-D-Glucose on Pro-Inflammatory Responses of LPS/IFNGamma-activated BV-2 Microglial Cells through NFƙB and MAPK Signaling Pathways CD14 IRAK1 SHE TRAF6 IRAK4 ARHA MYD88 CRK TIAM1 ITK TLR4 GRB2 LBP DOCK2 FADD TIRAP CDC42 PMC11545288__F6 PPI network analysis of core targets screened from potential targets (A) and network diagram of the active component–key target pathway (B) of sugarcane vinegar polyphenols to mitigate oxidative stress CDK2 PTGS2 MMP9 RELA NFE2L2 GSK3B CGA STAT3 PMC11545288__F7 Mechanistic Insights into the Antioxidant Potential of Sugarcane Vinegar Polyphenols: A Combined Approach of DPPH-UPLC-MS, Network Pharmacology and Molecular Docking TH FRY SP2 TRAF3 CCL20 LCN2 CCL2 S100A9 USP25 TNF S100A7 PMC7568159__F2 MyD88 and IRAK-4-mediated signaling pathway TLR8 TLR5 TLR7 TLR4 TLR9 IRAK4 MYD88 TLR1 TLR10 TLR3 PMC3099592__F2 Activation of mast cells initiates a cascade of events resulting in Th2 polarization and both positive and negative feedback regulatory loops JAK3 PMC5342987__F1 BMP4 cellular signaling pathway including activators and inhibitors BAMBI SMURF2 SMURF1 PMC3073545__F2 Endocannabinoids in Liver Disease LPL TG PMC4989048__F3 PhenomeExpress analysis SPARC dik HAPLN1 ZDHHC4 TNFRSF12A RUNX1T1 ZNF329 LGALS9 CDKN3 KIF1A SNRPN CLUH RAP2C MMS22L CFDP1 NPEPL1 BACH1 SOX9 L3MBTL1 RUTBC3 MAF FBLN5 SNCG PNMA2 TNFRSF4 BLCAP LRP1B MYO1B CD163 TNFRSF10D FAP COL9A2 FZD2 SERPING1 ROR2 TNFSF12 COL2A1 S100A4 PLAUR LGALS8 VCAN ATF3 LAMB3 MCM3 HMGA2 DUSP10 TRAF1 CCL20 IGFBP6 MAPK11 COMP HSD17B12 TOP2A DBF4 FZD1 COL1A1 ITIH4 PLAT IER3 LTBP2 CDC2 ETS2 IGF2 CD44 CEP55 TNFRSF11B PDGFC ACADL BUB1B GJA1 FHL2 TYK2 ZWINT SELP ST6GALNAC2 COL8A2 HLA-DQA2 TGFBI PMC11011352__F1 Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway LIN28B DGCR8 TUT4 DROSHA LIN28A PMC2912804__F7 Role of PGE2 in bridging TLR4 signaling and intestinal tumorigenesis COX2 TLR4 EGFR PMC6189293__F1 Complex interplay between O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway controls numerous biological processes TSC2 OGT MTOR PMC6189293__F2 O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway cross-dysregulation in human chronic diseases BAD MMP2 RUNX2 SMURF2 MMP9 GSK3B MTOR IRS1 HEL-S-133P FOXO1 PMC3583082__F3 This diagram summarizes the signaling pathway in thyroid carcinomas BRAF PTEN MTOR PMC3632399__F5 RAS oncogene signaling COX2 SP2 MMP2 FGF2 MMP9 VEGFA SP1 JUN PMC4048454__F5 Metabolic pathway of vancomycin biosynthesis CIT PMC8969440__F7 Cordyceps militaris Modulates Intestinal Barrier Function and Gut Microbiota in a Pig Model TLR4 TRAF6 MYD88 TIRAP PMC9454096__F1 Evasion of interferon-mediated immune response by arteriviruses ISG15 TANK SP2 STAT2 IRF7 SP4 TRAF6 IRF3 SP1 TLR3 MAVS PMC4248746__F10 Model depicting the molecular mechanism involved in counterregulation of TLR-induced inflammatory signature by dectin-1 IRAK1 PIAS1 SYK MYD88 PMC3457991__F3 Systematic Analysis of microRNA Targeting Impacted by Small Insertions and Deletions in Human Genome EGF BAD HEL-S-11 BRCA2 CASP9 SMAD4 JAK1 GLS PMC7757045__F4 LncRNA Regulates HCC Invasion and Progression by Modulating Tumor Immune Escape GADD45B LCK EGFR PMC8224460__F1 Resistance Responses of Potato Plants to Potato Virus Y Are Associated with an Increased Cellular Methionine Content and an Altered SAM:SAH Methylation Index CBL PMC12107760__F9 Changes in the main metabolic pathways of wheat root system in response to Act12 inoculation under drought stress PHOSPHO1 PAH PMC8933007__F4 Nicotinamide n-methyltransferase (NNMT) links nicotinamide adenine dinucleotide (NAD) and methionine metabolism during replicative senescence HEL-S-61p NAMPT MTR NMNAT1 NNMT PMC10960729__F6 Activation of cGAS–STING signaling pathway in autoimmune diseases, neurological diseases, and visceral inflammations DNASE2 ATM TREX1 C9orf72 PMC4066639__F5 Stress-signaling pathways in C HEL-S-99n HEL-75 RAC1 SP1 CDC42 PMC5445269__F3 Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans PINK1 SGK1 RHEB PMC8001543__F4 IL-7 effect on restoring 4-1BB signal transducer in HCV-specific CD8 T cells APC TRAF1 TGFB1 ELL PMC5528541__F9 A working model of Lhx2‐induced tumor progression SMAD2 SMAD4 PMC7118498__F2 TGFB 1 acts as a double-edged sword SMAD2 SMAD1 TGFB1 PMC6994220__F1 cis-carotene biosynthesis and regulation of PLB formation during skotomorphogenesis DET1 POR CR2 PMC7289600__F3 ERK and tested pathways EGFR RAC1 RAP1GAP PMC7118498__F1 TGFB 1 acts as a double-edged sword EGF ULK1 HGF STAT2 HEL-S-28 SMAD2 APC GSK3B MYC SMAD4 IL6 TNF MTOR HMGA2 MMP7 MAX ZEB2 GC SMAD1 IL1B TF DKFZp781O1323 PMC7326812__F5 Ingenuity pathway analysis (IPA) MAFB TEF EVI1 HNF1A KLF9 HCAR2 TNF ETS2 ANGEL2 NR1C1 PMC10244118__F8 Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/Beta-catenin signaling pathway ABCC1 AXIN2 ABCB1 LY6D PMC9218441__F2 Intestinal strictures in Crohn’s disease: a 2021 update ROCK1 IL13 APC GSK3B RHO NOD2 OSMR STAT3 PMC7575565__F6 RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells HGF RNF180 STAT3 PMC7019846__F2 Muscle protein synthesis and degradation signaling by omega 3 fatty acids (FA) ELF2 EIF4E MTOR TG IRS1 PMC7146513__F1 Specialized Pro-resolving Mediator (SPM) synthesis pathway and receptors GPR32 FPR2 GPR37 PMC10538533__F1 Updated roles of cGAS-STING signaling in autoimmune diseases CGAS IRF3 PMC6781272__F1 Generalized Toll-like receptor signaling mechanism, adapted from TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 TIRAP MAL PMC3303816__F3 Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis SEPT5 CASK SIAH2 FBXW7 PMC6224709__F4 Central carbon metabolism pathways in daf-2 and eat-2 mutants IAH1 FBP1 ACO2 PCK2 MDH2 HEL-S-68p PMC7393405__F1 Activation of the Main Innate Immune Receptors Involved in CVDs(A) Toll-like receptor (TLR) signaling pathway NLRP3 NOD1 MYD88 RIPK2 NOD2 PMC2799800__F1 Scheme of the model for the mammalian cell cycle CDC20 SKP2 PMC6178170__F10 Scheme showing a possible mechanism of the alleviated TLR-mediated inflammatory responses of macrophage U937 cells to the mycobacterial infection by coinfected A549 epithelial cells GSK3B TRAF6 MYD88 MTOR PMC4392729__F4 Th17 counteracts the effect of IL6 VEGFA IL6 IL5 PMC2948187__F1 Altered cellular pathways and processes in tumours PML EGFR RHO MTOR RAN CBL PMC8990939__F6 Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis HEL-S-30 ARHA HEL-S-133P CDC42 FASN HEL-S-162eP GLS PMC5779878__F6 The potential signaling pathways used by bufalin to induce apoptosis in SCC-4 human tongue cancer cells BAX PMC6590709__F5 Glycosylation in health and disease EGFR TNF PMC8892604__F3 Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives CD36 GLS PMC5765504__F5 PPARG signaling MUC13 NGF REN DGAT2 MGLL WNT1 HADHB CA3 CPT2 THRSP NR1i1 LPL FGF19 GPD2 KNG1 GPD1 SLC25A20 ADIG ANGPTL4 NUDT7 ACTA1 ELOVL6 PDK4 CYBB IGFBP5 TLR3 DBI MLXIPL ACADVL HEL-S-273 ACADM PMC11790812__F3 Apoptosis of tumor cell induced by Dioscin BAD ATM BAX PMC11356641__F4 Signaling pathway involved in probiotics recognition IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TIRAP PMC11790812__F4 Dioscin regulating autophagy in tumor cells MTOR PMC5409000__F6 Epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and Src-YES-associated protein 1 (YAP1) crosstalk RELA EGFR SRC TRAF2 PXN STAT3 PMC7822898__F6 Construction of lncRNA-related PPI networks linked to drug responsiveness in DLBCL NFKBIA SOX2 SETDB1 BCL7C BCL2 EIF4E MTOR STAT3 PMC6888083__F6 Mutual regulatory mechanisms among lncRNAs and miRNAs ZNRF3 E2F5 FGF19 RNF4 DKK1 APC2 BCL9 PMC7372134__F3 HO-1 dysregulation in cystic fibrosis (CF) MAF GSK3B HIF1A PMC7372134__F2 Hmox1 transcriptional regulation MAF KEAP1 GSK3B HIF1A HMOX1 BACH1 PMC5081262__F2 Major metabolic pathways in fatty acid metabolism: A) de novo lipogenesis and B) Polyunsaturated fatty acid metabolism SCD GLA FASN PMC3514907__F3 GeneGo “Cell Adhesion_ECM remodeling” pathway map EGF PLAUR PLG IGF2 EGFR CD44 MMP15 MMP16 LAMA4 SERPINE2 MMP7 PLAT IGF1 TIMP1 TIMP3 PMC4639852__F9 Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice EGFR IL6 STAT3 PMC11125634__F3 Schematic representation for DOCK11 and its partner AGAP2 regulating ARF1 activity to facilitate HBV retrograde trafficking EGFR DOCK11 ARF1 AGAP2 PMC11125634__F4 Proposed hypothesis explains the mechanism for the role of DOCK11 in HBV cccDNA formation and its modulation of histone modifications and RNA Pol II on HBV cccDNA DOCK11 ATR PCNA CDC42 PMC8204904__F5 Proposed signaling pathway that involves slit2/Robo2 and Nox2 activation during retinotectal pathfinding ROBO2 SLIT2 PMC2854285__F1 mTOR and cancer: many loops in one pathway TSC2 BAD TSC1 PTEN DEPTOR RHEB PMC10647618__F1 Canonical Hedgehog Signaling Pathway SUFU GSK3B SMO ADRBK1 PMC4199881__F1 Role of GKN1 in gastric cancer CASP3 COX2 FOV EZH2 CASP8 PMC6471725__F6 Cinobufagin-induced effects on hepatocellular carcinoma Huh-7 cells with mutant p53 CCNB1 CDC2 AURKA PCNA BAX PMC5190133__F1 Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment ING4 HMGA2 IGF1 RUNX2 PTEN EZH2 FADD FOXO1 BAX PMC3061066__F7 Model demonstrating the possible mode of action of hSSB1 ATM MDC1 RAD50 PMC5966718__F2 Detoxification of ammonia in the urea cycle and production of ornithine OTC ASL PMC9007670__F2 Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome NLRP3 TRADD TRAF2 FADD GSDMD PMC4287682__F1 MiR-15 family and its targets in the INSR signalling pathway BAD STX4A PTEN EIF4E ACLY GRB10 CRK IRS1 RPTOR INSR CBL PMC8110006__F4 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs SFRP4 WNT3 WIF1 PMC3227936__F1 EGFR signaling pathway EGF GRB2 HBEGF TGFA PMC8110006__F5 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs SFRP4 WIF1 PMC8110006__F3 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs PMC8258236__F2 Possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review IGF1R IGF1 ATF2 EGFR SP1 TERT PMC6600422__F2 Leptin receptor signaling is mediated by JAK-STAT, PI3K-Akt, and SHP2-ERK pathway SOCS3 GRB2 IRS1 STAT3 PMC4283135__F1 Canonical Notch signaling with points of intervention of current therapies RBPJ ADAM10 PMC3392028__F3 Seven important signaling networks of osteoblast differentiation RUNX2 BMP2 FGF2 APC SOST LRP5 PTH ADRB2 ARHA SMURF1 EPHB4 BMP4 ATF4 TGFB1 PMC3392028__F1 Transcription factors and signaling involved in the osteoblast differentiation pathway IHH RUNX2 EBP APC SMAD6 HOXA2 SMURF1 HES1 STAT1 LEF1 ATF4 MSC MSX2 HOXA10 SMAD1 MEF2C DKFZp781O1323 PMC9462519__F6 Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease TLR4 NOD1 RIPK2 IL1B PMC5364541__F8 Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway STAT1 OAS1 OAS2 OAS3 STAT2 IRF9 PMC4283135__F2 Notch signaling modules relevant for brain tumors NUMB TNC EGFR ITCH PMC4586474__F3 TGF-Beta-IDO-SHP axis IDO1 TLR4 AHR IRAK1 RELB TGFB1 PMC7193415__F8 GR Ser134 phosphorylation creates a feedforward signaling loop that potentiates further activation of the p38 MAPK pathway downstream of TGFB1 in TNBC models PIK3IP1 ATF4 SMAD2 LEFTY2 KLF10 SMAD4 PMC7764600__F2 Most important signaling molecules characterizing EBV + GC EGF HGF EGFR PTEN MTOR CDKN2A RCOR2 ARID1A PMC4586474__F1 Pathways of tryptophan metabolism IDO1 HEL-S-90n IDO2 PMC7764600__F3 Cellular degradation pathway of autophagy plays a fundamental role in immunity TLR4 TLR9 MTOR PMC2636986__F1 Adaptor protein containing pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif (APPL1)-mediated adiponectin and insulin-signaling pathways TSC2 ADIPOR1 TSC1 MTOR RHOB APPL1 PMC5853489__F3 DAL81 regulates expression of arginine metabolism in C. parapsilosis ARG2 ARG1 CPA2 CPA1 PMC6875424__F8 Possible mechanisms of the effects of methane against APAP-induced hepatic injury KEAP1 APP NQO1 PMC8245375__F5 Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity IRF7 IRF9 TRAF6 IRF3 IFNAR2 IFNAR1 TLR3 MX2 MX1 RNASEL STAT1 ISG15 TLR7 TLR4 PMC3032315__F3 Regulation of peripheral tolerance by the intrinsic and extrinsic apoptosis pathways in T and B cells BCR APC BCL2 BMF PMC3198933__F1 Toll-like receptor (TLR) signaling TBK1 TLR5 TLR9 TRAF6 IRF3 MYD88 TNF TLR1 TLR3 TLR8 TLR7 TLR4 MAL PMC6473131__F1 Possible mechanisms of cancers caused by Porphyromonas gingivalis MMP12 SOCS3 JAK1 IL1B STAT3 PMC8687455__F7 Analysis of Wheat Wax Regulation Mechanism by Liposome and Transcriptome MGLL TG DGKA HEL-S-5 PMC8013702__F3 MuV infection of testicular somatic cells and downstream effects ISG15 SOCS3 CXCL10 IL6 SOCS1 MX1 PMC12145571__F2 Skeletal muscle atrophy is a multifactorial process that essentially results from a disturbance in the equilibrium between protein anabolism and catabolism ULK1 IGF1 SMAD2 SMAD4 BNIP3 MTOR SMAD1 DKFZp781O1323 PMC4179679__F3 Metabostemness: a metabolo-epitranscriptional switcher OGT SIRT6 SIRT1 PMC12085564__F7 Cardiomyocyte specific CD38 deletion protecting heart from acute myocardial infarction MFN1 MFN2 BCL2 BAX SIRT3 PMC6538211__F2 Illustration of the WNK-SPAK/OSR1-CCCs cascade in nervous and non-nervous system diseases HEL-S-62p WNK1 WNK4 PMC11727142__F9 Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer GRB2 ENO1 SOS1 PMC4216607__F1 Management of Pediatric and Adult Patients with Medulloblastoma MAX APC MYC SHH SMO CDK4 PMC4706649__F2 Different apoptotic pathways are modulated by PEDF CASP3 CASP9 BCL2 CASP8 FADD BAX PMC5906968__F1 Schematic representation of the regulatory pathways affecting gene expression during mouse spermatogenesis P1 AKAP4 PMC5279772__F6 Inhibition of NFKB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy RELA CSA2 FADD PMC4681408__F6 Patient-specific Immune States before Surgery are Strong Correlates of Surgical Recovery CD14 HMGB1 MAPKAPK2 TLR4 RELA RPS6 PMC10605590__F7 The potential non-genomic P4 action in colorectal cancer CXCR1 PGRMC2 NENF PGR PMC4693471__F2 Gene‐by‐age interaction miRNA–mRNA network analysis MED12 BOC ASB1 NFKBIZ PPARGC1B MAF NTN1 ATOH1 NOTCH1 FOXG1 NOTCH2 MYCBP2 FOXO1 NTF3 VAMP2 GABPB2 CDH4 YAF2 CXCR4 TEX14 SIX3 DGKZ BCL2 RAI14 SCA7 NRN1 ELF4 ANKRD12 BDNF SYP TRANK1 CPLX2 ABLIM3 TBX20 SEMA4F SHANK3 MSX1 GAS1 SLIT3 CELSR3 MTA2 TEAD3 MAML2 NCOA1 HMGB1 TANC2 USF1 STXBP1 RTN4 SNAP25 PTF1A LEF1 HNF4A AGAP2 PMC2576563__F7 Tight regulation of MUC5AC mucin induction by pneumolysin via PAK4-JNK and MKP1 signaling pathways TLR4 MUC5AC TRAF6 PAK4 MYD88 PMC8510947__F2 STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function COX2 SOCS3 MCU STAT3 PMC10960729__F4 Activation and inhibition of the cGAS–STING signaling pathway in viral infection TBK1 CGAS ENPP1 TNF IL1B PMC10960729__F5 Tumor suppression and promotion of the cGAS–STING signaling pathway CGAS BRCA2 PMC10960729__F2 Triggers of cGAS–STING signaling pathway CGAS PQBP1 NONO PMC10960729__F3 Signal transduction mechanism of cGAS–STING TBK1 CGAS IRF3 PMC5874524__F8 LGM2605 inhibition of asbestos-induced NLRP3 inflammasome activation by blocking asbestos-induced reactive oxygen species (ROS) generation and activating the Nrf2-ARE pathway NLRP3 KEAP1 IL1B TXN NQO1 PMC8649885__F1 Schematic showing the reported genetic determinants of human EEA and EEAF TUBB8 MOS KHDC3L PADI6 NLRP2 TLE6 PMC5447385__F7 HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease HMGB1 TLR4 RAC1 PHAX PMC3521387__F9 ILOCi detected genes from T1D and their maps in 'type I diabetes mellitus' pathway INS PTPRN2 PRF1 HLA-DQB1 TNF HLA-DQA2 IFNG PMC3521387__F7 ILOCi detected genes from BD and their maps in 'neuroactive ligand-receptor interaction' pathway PLAT LEPR CALCR LPA HTR2A PRL PMC3521387__F8 ILOCi detected genes from CAD and their maps in 'cytokine-cytokine receptor interaction' pathway LTA SAG POR OSM PRL PMC11964952__F2 Proposed chart of T1D dual vulnerability initiated by Beta-cell metabolic dysfunction and CD4+ T-cell activation APC EIF2A ATF3 TXNIP TYK2 GIP CD80 CTSH GLIS3 XBP1 GSDMD PMC11964952__F3 T1D targets for therapeutic interventions in endocrine cells PDX1 BAD SST GIPR EGFR INS HBEGF GCG NKX6-1 CCND2 GCGR NLRP3 CDK4 TXNIP ARX ALDH2 PMC11964952__F4 T1D targets for therapeutic interventions in immune cells IL21R DPP4 APC TNF CD69 MAFA IFNG IGF1 CD2 STAT4 CREM TXNIP CD80 IRF4 CD19 PMC10378789__F2 Revisiting the Role of Autophagy in Cardiac Differentiation: A Comprehensive Review of Interplay with Other Signaling Pathways ULK1 ATG16L1 ATG12 ATG3 C6 BCL2 ATG10 MTOR ATG14 DKFZp686F0183 PMC8773620__F1 Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment? SUFU SHH SMO PMC4051158__F1 Role of the CD40–CD40L pathway during the CD8 primary response APC CD40 PMC8840228__F2 Muscle stem cell adaptations to cellular and environmental stress ELF2 F2 ATF4 PMC8840228__F3 Muscle stem cell adaptations to cellular and environmental stress TSC2 TSC1 EIF4E PMC9102653__F2 Subversion of the immune response of human pathogenic spirochetes C4B_2 MASP2 C1S C4A CP PMC9330218__F3 Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer EGF SCD EBP LDLR ACLY MTOR SIRT1 HMGCR RAX2 FASN PMC4051158__F5 The CD40-CD40L pathway plays a critical role in CD4 T-cell–mediated IL-21 production during the rescue of exhausted T-cell response IL21R CD40 PMC7754534__F6 Proposed model of adenine-activated-hepcidin axis Adenine induces activation of cAMP/PKA signaling pathway, which in trun stimulates the activation of both SMAD1/5/8 pathways resulting in transcritional activation of hepcidin gene expression HAMP SMAD4 SMAD1 PMC3706439__F2 Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae CIT ACD MAL PMC9382032__F7 Genetic and transcriptome analyses reveal the candidate genes and pathways involved in the inactive shade-avoidance response enabling high-density planting of soybean SHE MAL PMC4983807__F4 Members of receptor tyrosine signaling pathways that are predicted as indispensable nodes and targeted by cancer mutations, OMIM disease, viruses, or FDA-approved drugs PIK3R1 MAPK9 MAPK8 MAPK3 SMAD2 GSK3B MYC MAPK14 SMAD4 RB1 PDPK1 CDK6 FGFR1 MDM2 MAPK1 CSK VAV1 MAPK7 ERBB3 HRAS IRS1 RET PAK1 IGF1 NFKB2 BCL2 CDC42 IGF1R MAP2K4 TGFBR1 EGFR TGFBR2 INS EEF1A1 INSR RARA CCND1 JUN NTRK1 IGF2 RAC1 DVL3 CREBBP MAP2K1 ERBB2 LCK JAK1 RAF1 SOS1 SHC1 EPHB2 PMC5495464__F3 Interactions of IGF and ERB signaling pathways in malignancy EGF IGF1R IGF1 IGF2 EGFR MTOR IRS1 IGF2R STAT3 PMC4458429__F2 Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases NEDD9 SRC SYK MTOR PXN CRKL PMC9302318__F6 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome CD14 EGF TRADD FLNA TNF NLK MAX HP GRB2 JUND ECSIT RAN TRAF2 PMC9302318__F7 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome BAD CD37 MYC PTEN RAC1 MTOR BRCA1 RHEB TSC2 BCR MDM2 GRB2 CYC1 SYK GAL RBL2 CD19 PMC8709142__F1 Beneficial Properties of Bromelain BAD CCNC BAX PMC6236434__F4 Mechanisms mostly deemed to contribute to the development of APAs TH LEF1 APC LRP5 NACA2 LRP6 ARHA KCNK5b CYP11B2 PMC6535783__F1 RNF8 involves in DSB signaling pathway JMJD1C RNF168 PALB2 RNF8 ATM MDC1 RAD51 L3MBTL2 FAT10 CHD4 H2AX DYRK2 PMC11499591__F3 ApoM/S1P, Wnt/beta-catenin, and PI3K/AKT/mTOR signaling pathways involved in intestinal barrier damage APOM SPHK1 MTOR SIRT3 PMC4398256__F1 MTOR signaling and metabolic regulation TSC2 RICTOR TSC1 FYN LCK ZAP70 MTOR DEPTOR RHEB MLST8 PMC8466097__F2 Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer BAD RECK APAF1 MTOR PCNA BAX PMC8771504__F6 Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through B2-AR/ERK/EMT pathway CDH2 PMC5308218__F4 Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization PIK3R1 TUBA4A HEL2 NCK2 HEL-S-1 ACTN1 TEC HSPD1 CAPZA1 CRKL DOK1 NCK1 ITSN2 AVIL LRRK1 BCR NCKIPSD NCKAP1L HGS CPNE2 PTPN11 EPS15L1 MAJN STAM2 SH3BP1 CAPZB HEL-S-133P CD2AP CAPZA2 RAPGEF1 YBX1 CSK WASF2 HEL-S-87p CRK PHGDH CBL GNG12 PPP1CC NEDD9 GAB2 GRB2 CYFIP2 HEL-S-93 SHC1 PIK3R2 PMC3257580__F1 Kruppel-like factors in lymphocyte biology KLF10 KLF4 KLF2 KLF13 KLF3 PMC12081410__F11 Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway CDK2 CDK4 PCNA PDPK1 PMC6527596__F1 The regulatory mechanism of miRNAs in TLR signaling TLR9 IRAK1 IRAK2 TRAF3 TRAF6 MYD88 TNF TLR1 TLR10 SOCS6 SNAP23 TLR3 TLR8 TLR7 TLR4 NFKB1 IRAK3 IL1B SOCS1 PMC11653707__F1 MTOR signaling in activating TME cells TSC1 EGFR JAK1 MTOR RHEB PMC3518582__F3 Wnt7a signals bidirectionally through divergent pathways to influence both presynaptic and postsynaptic assembly and to promote excitatory synapse formation and function MAP1B WNT7A GSK3B PMC6363035__F3 Schematic Representation of DDR1-collagen signaling pathway in cancer COX2 SRC CDH2 RPS6 TM4SF1 STAT3 HES1 PMC3518582__F1 Wnt Signal Transduction Pathways MAP1B APC LRP5 LRP6 RHO PMC5357236__F1 microRNAs in lipoprotein metabolism and cardiometabolic disorders ABCG1 ABCA1 ABCB11 CYP7A1 PMC3710321__F1 Regulation of STATs by polycystin-1 and their role in polycystic kidney disease STAT1 EGF HGF IL13 SRC IL4 STAT3 PMC3124048__F1 Parallels in haematopoiesis between the Drosophila LG and mammalian bone marrow CDH2 PMC9366230__F8 Cell membrane coated-nanoparticles for cancer immunotherapy PIR PMC5392015__F4 GHRP mechanism of action IGF1 MTOR ACE2 TGFB1 CD36 PMC10671516__F3 Granulosa cell glucose and lipid metabolism on oocytes ADFP HEL-S-133P CCS HEL-S-281 PMC11988865__F6 Regulatory mechanisms of Brandt’s vole brain tissue in response to hypoxia HEL-S-49 BAD KLF4 PTEN HDAC1 HEL-S-68p PMC7723926__F1 Schematic depiction of unfolded protein response (UPR) signaling cascade, and the interplay between endoplasmic reticulum (ER) stress response and inflammation NLRP3 ATF4 EIF2A TXNIP IL6 RTCB XBP1 PMC3759367__F11 Signaling pathway and proposed sites of arsenite perturbation EGF SMAD4 NOTCH1 DUSP2 SMAD1 KRT1 DKFZp781O1323 KRT10 FOXN1 PMC3158097__F1 Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy APC GSK3B PMC10671516__F1 Paracrine-mediated signaling between granulosa cells and oocytes SMAD2 BMP15 CASP9 HAS2 SMAD1 STAR DKFZp781O1323 PTX3 BAX PMC3638465__F1 Metabolic map showing selected pathways of D SLA FES CBL PMC5983649__F1 Schematic overview of Annexins at the crossroad of late endocytic pathways NPC1 STX6 SLC38A9 STARD3 RHEB PMC3737723__F8 Model of the Prdm1a gene regulatory network for NCC specification NPB FOXD3 TFAP2A SOX10 GRN PMC8508234__F9 Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer ATM APC CYC1 HCTP4 RAN PMC6895975__F2 Extracellular regulation of mesendodermal gene expression DAND5 NODAL SMAD4 NDP BMP4 PMC3070849__F1 Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation BTK PI3 PREB IRF8 BASH AID SYK PTEN JAK1 IRF4 FOXO1 CD19 PMC4020801__F3 Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration FGA SERPINC1 GPX3 HRG HEL111 DDN ALB SERPINA1 PMC4441360__F6 EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma ERBB3 EGFR TGFA PMC7746484__F1 Toll-like receptor (TLR) signaling pathways TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 TIRAP PMC9516464__F2 Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease MSC CXCL9 IL25 ARG1 TLR3 BAX PMC4250281__F1 Cellular signaling through pre-organized and inter-connected nanocluster assemblies with gel-like properties APC EGFR GRB2 IQGAP1 RAC1 MTOR S100B CDC42 PMC9304635__F2 Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis PCSK9 CES1 ABCG8 ABCG5 LPL LDLR NPC1L1 ABCA1 TG SIRT1 CYP7A1 CD36 PMC8797823__F5 Frizzled receptor expression on patients’ survival with gastrointestinal cancers: A systematic review with meta-analysis CSK APC RHO RAC1 PMC5983650__F9 Bornyl cis-4-hydroxycinnamate-induced apoptotic pathway BAD ATF4 EIF2A HEL-S-99n BAX PMC8799916__F2 Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures BAD FYN GLI3 EGFR SRC SMO BAX PMC11568601__F9 Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway PARP1 XBP1 PMC4673555__F4 Proposed GC-C signaling in colitis HNF4A CDX2 GUCY2C PDE3A SLC9A3 GUCA2B HNF1A CFTR PMC7684869__F2 Schematic figure of NPY and leptin in local homeostasis of bone remodeling NPY ADRB2 PMC5454045__F2 FGF signaling pathway FOS ETV4 ETV5 JUN PMC6523677__F2 MicroRNA-mRNA network constructed using CyTargetLinker CDA RRM1 RRM2 DCTD PMC3342058__F2 Major therapeutic targets for inhibition of donor-reactive memory T cell responses CD27 HEL-S-171mP TNLG8A CD80 MTOR ICOS PMC6775293__F8 Pathway of Alzheimer's disease CASP3 CASP12 BAD APAF1 LPL CASP9 APP CA9 TNF IRF-1 FADD APOE PMC4178318__F10 Schematic of Rab23 functions in chondrogenic cells RAB23 SOX9 PMC4837341__F4 Drug target identification using network analysis in Sini decoction DAO GCK MIOX PISD HEL-S-87p ASPA PEMT CDIPT FADS2 ASNS PLA2G3 LPCAT4 AGXT GLDC CAD PLA2G10 PMC9271168__F2 C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways KEAP1 ATG3 DKFZp781B1423 HIF1A HSF1 EIF2AK1 SYVN1 CEBPG DKFZp686F0183 XBP1 TP53BP1 TAOK1 CHEK2 ATM ATF4 EIF2A MDM2 JUN ELF2 ATG16L1 ATG12 NCL PPM1G LONP1 NFE2L2 VHL ATG101 ATG10 HSF2 PPP1R15B GCN1 DDIT4 EGLN1 DNAJC3 ADM2 CDKN1A MAFK AMOTL2 PPM1D ASNS ERN1 EIF2AK4 PMC7330693__F8 GINS2 interference induces apoptosis and cell cycle arrest CCND1 CDK4 GINS2 PMC7382369__F4 Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS TSC2 TSC1 UMPS CAD DHODH PMC3168773__F2 Functional relationship linking Crb proteins to the SWH pathway SMAD2 CRB3 PMC9655342__F3 Targeted Therapies in Advanced and Metastatic Urothelial Carcinoma TSC2 PAK1 ERBB4 TSC1 FGFR1 ERBB3 MDM2 GRB2 FGFR3 FGFR4 FGFR2 RHEB PMC8971665__F4 Retinoblastoma Protein Paralogs and Tumor Suppression CDKN3 RB1 CCND3 CDK6 CCND2 CCNE1 CDK2 CCND1 CDK4 RBL2 TF RBL1 CCNE2 PMC6232344__F3 Compounds and hitting targets on ICH NLRP3 TLR4 CASP9 BAX PMC6039985__F3 In PDA cells, E47 directed an integrated program of gene expression that controlled cell-cycle progression MIA XPC HEL-S-162eP PMC2939298__F1 Schematic diagram of androgen biosynthesis CYP11A1 HSD3B2 HSD17B3 RDH5 AKR1C2 CYP17A1 PMC7956267__F2 Transcriptional regulation involved in activating salt stress-responsive genes in rice MYB CTCF ERF PMC6557283__F2 YAP/TAZ signaling and resistance to chemotherapy CSF3 CXCL5 IL8RB CSF2 CSF1 PMC6557283__F1 YAP/TAZ signaling and resistance to targeted therapy TBK1 MOB3B EGFR ERBB3 TEAD4 LATS1 LATS2 TEAD2 TEAD3 NF2 GRB2 AXL BRD4 PMC7291251__F1 Upstream and downstream mTORC1 signaling TSC2 ULK1 TSC1 TBC1D7 MTOR DEPTOR RHEB MLST8 PMC5642500__F7 HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma ERBB3 EGFR GRB2 VHL MTOR PMC5051268__F2 Multiple Faces of FGF-23 FAM20C ENPP1 FGF23 FGFR1 PTH ACE2 DMP1 CYP27B1 PMC4312599__F5 Coordinately up-regulated genes of WNT signaling pathway in HCV versus HIV BAMBI ROCK2 NLK SIAH1 APC SOST CER1 SMAD4 SKP1 ARHA RBX1 PMC9366716__F2 Cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts MID1 ST14 HMFT1766 PMC7344072__F2 Mechanism by which proinflammatory cytokines in the OA knee joint stimulates MSCs to produce IDO1 STAT1 IDO1 BIN1 PMC2603552__F10 Role of oxysterol sulfation in lipid metabolism STS SULT2B1 ABCA1 PMC4346193__F5 Schematic model illustrating how IGFBP-3 proteins regulate the TNFA and apoptosis pathway in REC: Right TIMP3 TNF PMC11979195__F2 Modulating oxidative stress: a reliable strategy for coping with community-acquired pneumonia in older adults MAF KEAP1 PMC3103151__F1 Intracellular pathway of folate metabolism with highlighted critical pathways of methotrexate (MTX) entry, effect and efflux RFC1 ABCC3 GGH ADA HEL-S-70p FPGS ABCC2 ABCB1 PMC5992473__F9 Schematic Illustrates a Model of miR372 Promotes Liver Cancer Cell Growth by Upregulating erbB-2 through Enhancing YB-1 via Targeting for PTENmiR372 accelerates malignant progression of liver cancer cells in vitro and in vivo ERBB2 CDK2 CTCF PTEN TCF4 PMC8616315__F2 Multiple Interactions of RUNX with the Hippo–YAP Pathway RUNX3 LATS1 LATS2 PMC6528874__F1 Anti‐tumour effect of TNFA and IFNG alone and in combination TCP1 IFNG PMC3382253__F4 Mitochondria biogenesis allows tissue adaption under stress SMAD2 SMAD4 PMC10750205__F2 Endosialin in Cancer: Expression Patterns, Mechanistic Insights, and Therapeutic Approaches MMRN2 CLEC14A PMC3382253__F3 Mitochondria are central organelles in determining cell fate in liver diseases APAF1 FADD BAX PMC8899336__F1 Wnt signaling in biliary development, proliferation, and fibrosis LEF1 APC RHO PMC7785817__F2 Structures of Slit/Robo, and the Slit-Robo signaling pathway SRGAP1 ARHA CDH2 CDC42 PMC8899336__F2 Wnt signaling in biliary development, proliferation, and fibrosis FGF4 HGF BMP4 PMC2548289__F1 Hereditary Hemochromatosis in the Post HFE Era HFE TFR2 PMC9562887__F2 “Sweet Spot” of Targeting Tumor Metabolism in Ovarian Cancers PTEN MTOR STAT3 PMC5548184__F4 Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide PML BAD PTN RERG AAMP CIT MTTP CUBN ARG2 APP GPHN APOE LIMK2 EGR1 PDGFRA MAPK7 UBE2H AIRE TCN2 CTSH ATG10 AMN SERPINE2 GATA4 NAPRT HEL-S-102 RPS25 RTN1 PKN3 LYN ATN1 APRT PCTP S100A13 SRGAP2 SRGN ELAC2 BOK PMC3437636__F2 Formation of the NFKB-stimulating TNFR1 signaling complex TRADD TRAF2 FADD PMC8516864__F4 Tryptophan/kynurenine pathway TH HEL-S-90n KYNU KMO PMC8516864__F2 Polyamine pathway and Cadaverine pathway ASNS SRM SMS PMC4353374__F2 SIRT1 in synaptic plasticity LIMK1 YY1 MTOR BDNF SIRT1 PMC7484393__F3 Correction: Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission NLRP3 TLR8 TLR7 IRF7 IRF3 MYD88 TNF IL1B TLR3 PMC11126064__F8 Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis TNF NQO1 BAX PMC8063048__F1 Roles that dopamine receptors play in regulating inflammasome formation as well as NFKB pathway NLRP3 HEL-S-101 HEL-S-69p PMC8063048__F2 Roles that dopamine receptors play in macrophages IL2 IL4 STAT3 PMC6666404__F4 Longitudinal multi-omics of host–microbe dynamics in prediabetes IL10 SNCA HEL-S-11 APP DES WAS TG GLS PMC5418445__F1 Tumour angiogenesis: molecular pathways and potential interventional strategies HGF RHO RAC1 PMC10940030__F4 Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases FYN GAB2 SYK RHO SKI MTOR ARF1 PMC4538325__F3 Signaling pathways modulated by electrophilic lipids MAF KEAP1 HSF1 PMC6321423__F3 Schematic depiction of the TGFB signaling pathway SMAD2 TGFBR1 SMAD4 STAT3 PMC8618532__F2 Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function IL4 MTOR SIRT1 BATF SIRT3 PMC7718329__F7 TET1 and 5hmC in an obesity-linked pathway driving cancer stem cells in triple-negative breast cancer TARDBP TET1 PMC8740020__F3 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design SOCS3 EIF2A SOCS1 PMC3686733__F2 Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets ASPA HEL-S-133P GALP PMC2575825__F9 Redox-sensitive steps in hypothetical redox signaling pathways TLR4 IGF1 EGFR SRC PTEN NOX5 TGFA PMC7041777__F3 Interactions between AB, WNT pathway and energy metabolism in AD APC LRP5 LRP6 PDHX HEL-S-133P PMC8740020__F2 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design ELF2 ATF4 ATF3 XBP1 PMC2575825__F4 Glutathionine (GSH) redox network GLRX2 RBP1 EGFR PTGES HRAS CFTR HAGHL PMC3739939__F4 Pathway analysis showing integration between signaling pathways, transcription factors, and adhesion genes SNAI1 TWIST2 TWIST1 ZEB2 SNAI2 HEL113 SOX10 PMC6933333__F7 LncRNA TNRC6C‐AS1 silencing inhibits proliferation and promotes apoptosis and autophagy of TC cells STK4 LATS1 LATS2 PMC5516868__F1 Snf1 pathway and its components SIX5 NRG2 NRG1 GAL HSF1 PMC9042615__F7 Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway IL16 LGR6 PMC4564008__F1 Regulation of Hedgehog signaling by ubiquitination SUFU PTCH1 PMC8076792__F1 Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? NPC1 CYP46A1 SCD ABCG1 DHCR24 CCL18 ABCA1 NPC2 IL1B HMGCR FASN FOXP3 PMC8514848__F1 RASopathies: From germline mutations to somatic and multigenic diseases NF1 CS ECD BRAF APAF1 SPRED1 BCL2 MTOR ARAF BAX CBL PMC3798821__F6 The ILK signaling and its putative regulation by the micro-RNA-1 (miR-1) HEL-S-28 MYC SNAI2 CCND1 PARVA PMC8787047__F3 Accentuating CircRNA-miRNA-Transcription Factors Axis: A Conundrum in Cancer Research USF1 FOXO3A SMAD2 SMAD4 YY1 CDK4 CDH2 MTOR CDK6 BAX PMC3798821__F4 The valine degradation pathway from the differentially regulated genes in response to 3–7 days of mechanical overload KLF15 BCAT2 HADHB DLD DBT EHHADH PMC6889001__F2 Atherothrombosis and the NLRP3 Inflammasome – Endogenous Mechanisms of Inhibition NLRP3 PTMS IL18 TLR4 SIRT3 PMC3872295__F1 Mechanistic model to show how mechanical forces promote differentiation of fetal type II epithelial cells via release of soluble growth factors HB-EGF and TGFA with subsequent binding and activation of the EGFR and ERK signaling pathway EGFR HBEGF TGFA ADAM17 PMC9298356__F1 CAM photosynthesis: the acid test HEL-S-62p CS PMC6595533__F2 The proposed mechanisms by which norepinephrine (NE) and corticosterone/cortisol (CORT) regulate sterile inflammation CORT XCR1 NLRP3 HMGB1 CX3CR1 IL1R2 IL1R1 CR1 PMC8471002__F4 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models HEL-S-28 SMAD2 ARHA LATS1 LATS2 PMC3334885__F1 T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice NUSAP1 PKIG LBR TTK HEL164 LSR PGRMC1 TGFB1 TSPYL2 CENPA PMC5334311__F1 The compensatory B‐cell proliferative signaling network mediated by insulin resistance TSC2 TSC1 GSK3B CCND2 PMC8471002__F2 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models TLR4 HEL-S-28 TRAF6 ARHA IRAK4 MYD88 MAP3K7IP1 IL1B PMC8471002__F1 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models SMAD2 APC SMAD6 SMAD4 PMC8204080__F1 O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function OGA OGT GSK3B IRS1 PMC10999050__F3 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis PTGS2 MYC TNF FOXO1 CALM1 PRKCA CASP3 TNFSF6 CDKN1A RELA CASP9 CCND1 CASP8 IL1B STAT3 BAX PMC7699474__F3 Protein interaction networks (PPIs) for ploidy associated c-MYC -interacting bivalent genes BASH MYC NTS PBR PMC8961648__F4 Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast HEL-S-26 PCK1 ARG1 GAD1 HEL60 PMC8177011__F7 Expression of Nutrient Transporters on NK Cells During Murine Cytomegalovirus Infection Is MyD88-Dependent IL33 HEL-S-92n MYD88 PMC5955790__F1 Tumor necrosis factor A (TNF) regulation in health and disease and its sleep-linked effectors and actions IL10 IL37 CRH IL6 IL4 TNF GHRH PMC6610925__F1 Hexosamine biosynthetic pathway PGM3 OGA OGT PMC4615139__F6 Proposed mechanism of cordycepin-induced apoptosis and cell cycle arrest in NB-4 and U937 cells CCNA2 CDK2 PMC6610925__F3 Hexosamine extended and salvage pathways GNE NAGK OGA OGT PMC6610925__F4 HBP regulates multiple proteins in cancer cells via OGT FOXO3A OGT ATF2 FH MTOR H2AX PMC8457844__F2 Classically known renin angiotensin pathway and the inhibitors identified from our high throughput screen AGTR1 AGTR2 PMC8571027__F4 Arginine methylation negatively regulates the anti-viral response TBK1 CGAS PRMT7 PRMT3 PRMT6 IRF3 MAVS IFI16 PMC5084027__F4 AMP-activated protein kinase (AMPK) signaling pathway EEF2K TBCD EEF2 INS CPT2 GYS1 MTOR HMGCR RPTOR CFTR INSR LIPE SLC2A4 SRC MLYCD ADRA1A ADRB3 FASN PMC6794370__F7 Mitochondrial dynamics in cancer MFN1 MFN2 MIEF2 MFF MIEF1 FIS1 OPA1 PMC6794370__F2 Mitochondrial physiology PDC FES CYB PMC9439649__F4 CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges TSC2 BAD TSC1 FOS ATF2 MDM2 CCND1 BCL2 MCL1 MTOR MEF2C CCNE1 PMC12124620__F4 A) The role of notch signaling pathway in the aging of MSCs CCND1 HES1 PMC9526582__F2 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer CEMIP FCGBP CASK TMEM200A TMPRSS3 NRXN3 HSPB3 SOHLH2 POTEE KIFAP3 SPANXD MAGEA2B HPDL FYN PALLD ASB9 SSPN DAZL CDK14 CADPS TFF3 ABCC2 SERPINB2 MVP CD68 PF4 THSD4 IGF2 NTS CD200 APBB2 ALPL IGFBP2 HEL113 MYLK TGFBI PMC4592163__F1 Endoplasmic reticulum stress inducing autophagy ATF4 EIF2A PMC6098222__F2 Stimuli-induced TLR2- and NOD2- mediated signaling LTA TRAF6 MYD88 MAP3K7IP1 NOD2 TIRAP MAL PMC2715236__F6 Model for the role of FANCM in the DNA damage response FANCD2 FAAP24 FANCM PMC5385391__F9 HMGB1 release regulated by the PLCG1–IP3R–SOC signalling pathway during calcium overload in hepatocytes HMGB1 ORAI1 STIM1 PMC9537025__F1 Mass spectrometry-based approaches to explore metabolism regulating ferroptosis GPX4 LPCAT3 FACL4 GCLC DHODH PMC4047366__F11 Metabolic feedback via HBP and N-glycan branching GCGR MGAT5 MGAT1 MGAT2 PMC8889000__F3 Autophagy: a multifaceted player in the fate of sperm KIT GJA1 NANOS2 RAB1B GOPC PICK1 RAC1 SIRT1 RHEB IFT20 PMC7500163__F1 Pathways expressed during humoral immune response of SARS-CoV-2 infection NFKBIA VEGFC CD6 ATF4 MMP9 MDM2 VEGFA KITLG TRIM25 PMC7017144__F10 Pathway signaling network generated from the genes located within the top 100 DM tiling regions FGF21 PRKCE CSNK2A2 ROCK1 CSNK2A1 ATF2 DST SNAI2 PAK4 SMAD4 ADAM19 STAT1 JDP2 HPGD PLAT ERBB4 POLE ATM SRC CCND1 GDNF ITSN1 ARVCF FBXL17 IRF2BP1 IRF2BP2 IRF2 VRK1 CREB5 CCL11 PLK3 ERBB3 NR3C1 ARHGAP24 FKBP5 NRG1 KCNB1 TWIST1 SUFU ERBB2 LYN ERBIN RAN CTNND2 PXN CDC42 PMC3715061__F1 Hedgehog signaling, vismodegib action, and acquired resistance PTCH2 SUFU PTCH1 GLI3 SMO PMC8652134__F3 Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease PCK1 NOTCH1 HEL-S-128m TG PMC5568783__F2 PERK arm of the unfolded protein response EIF2A BCL2 XBP1 BAX PMC4051800__F6 Causal BN learned from breast cancer cases for the ErbB pathway EREG PIK3R1 MAPK9 MAPK3 MYC NRAS PLCG2 CRKL NCK1 PRKCA BTC SRC MAPK1 ABL2 SOS2 AREG CDKN1B ERBB3 MAPK10 NRG2 HBEGF HRAS CRK PIK3R3 SHC2 PAK1 GRB2 TGFA CBLC AKT3 PLCG1 NRG3 EGF BAD BRAF NCK2 EGFR EIF4EBP1 SHC3 ERBB4 ARAF JUN CAMK2D CAMK2G MAP2K2 NRG1 CBL ERBB2 PIK3CA RAF1 SOS1 NRG4 PIK3R2 PMC2100400__F2 Innate and Adaptive Immune Response to Apoptotic Cells MFGE8 PC CRP PMC5568783__F1 IRE1A arm of the unfolded protein response NLRP3 IL16 UNK TXNIP XBP1 BAX PMC3735949__F3 Comparison of gene expression in RAW264.7 (RAW) and TGEM cells treated with KLA for the TLR4 signaling pathway TBK1 IKBKG IFNA1 IRAK1 TICAM2 RELB TRAF3 IRAK4 LY96 TICAM1 COX2 RIPK1 NOS2 CASP8 MAL CD14 IL1A IRF7 PTGS2 MAP3K7 MAP2K2 IRF3 IFNB1 TNF IKBKB NFKBIB MAP2K1 VCAM1 RELA CTRL REL TNFAIP3 IRAK3 FADD TIRAP PMC3983408__F7 Mechanism of immune dysfunction in Huntington’s disease IRAK1 IRAK4 IL6 PMC3887194__F13 Schematic modeling of the TcpB inhibition of TLR4 signaling TLR4 MYD88 MAL PMC5762524__F3 Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus CD14 NLK MOS FLNA ATF2 EGFR GRB2 TRAF6 ECSIT TRAF2 MEF2C JUN PMC6378226__F1 Cell death pathways currently implicated in motor neuron cell death in ALS and related miRNAs CASP3 CASP9 CASP8 FADD MLKL BAX PMC4031100__F3 Nutritional metabolomics: Progress in addressing complexity in diet and health OMP SLC25A13 SLC6A12 MAL PMC10453317__F2 GAB1 recruitment modes to activated receptors and major GAB1 signaling pathways GRB2 CRK PMC4292994__F3 Host genes with reproducible microbiome associations across cohorts TXK IKBKG HEL-S-71 IL23A MAPK14 DAP RIPK2 IL12A MAP3K7IP1 NOD2 IL12B STAT3 PMC4630209__F2 KIT-mediated signaling events KIT BTK FYN GAB2 LYN GRB2 PMC8166497__F5 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis MAF HRK PMC11077654__S1 Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus OSR1 CSF1 PMC4890577__F1 Bile acid signaling in murine hepatocytes EGR1 S1PR2 PMC8166497__F4 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis BTK APP ACR PMC312639__F9 Proposed model for RhoA signaling to the c-jun promoter ARHA RHO CDC42 PMC4079737__F1 Molecular Pathways: Niches in Metastatic Dormancy BMPR2 BCL2 BMP7 AXL PMC7285711__F3 Interaction network analysis of the (A) visceral obesity pathway and (B) the cell cycle pathway, using the path designer of IPA THRAP3 SHOX2 CCNH RB1 TFDP1 CCNE1 PMC5452017__F2 Brain metabolism in health, aging, and neurodegeneration F2 APC PDK4 PMC5115734__F5 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement FECH UROD UROS CPOX PMC5452017__F3 Brain metabolism in health, aging, and neurodegeneration AACS HMGCS1 ACLY PMC9285394__F6 Vascular smooth muscle cells in the development of aortic aneurysms and dissections ACTA2 SMAD2 TGFBR1 TGFBR2 FBN1 SMAD4 PRKG1 MYLK PMC5452017__F5 Brain metabolism in health, aging, and neurodegeneration NRF1 BDNF TFAM SIRT3 PMC9645596__F1 TGFB: Signaling Blockade for Cancer Immunotherapy USP4 USP15 SMAD2 TGFBR1 TGFBR2 SMAD4 TRAF6 RHO SMURF1 USP11 SMURF2 GRB2 TRAF4 PMC3812160__F7 Transcriptome-Wide Mapping of Pea Seed Ageing Reveals a Pivotal Role for Genes Related to Oxidative Stress and Programmed Cell Death UBC LRSAM1 PRX PMC3693914__F2 DA biosynthesis and degradation TH PMC524522__F9 Mapping molecular correlates of aggressive mesothelioma to highly curated molecular pathways can identify the underlying molecular mechanisms of the disease WEE1 ADA BTG2 RXRA PMC9433080__F1 Treating non-small cell lung cancer by targeting the PI3K signaling pathway TSC2 BAD TSC1 FOXO3A MDM2 CASP9 RAD51 RHO PTEN CHEK1 FOXO1 RHEB PMC3792429__F1 Hierarchy of nucleolar stress-induced neuroprotection NCL MDM2 PTEN MTOR PMC4227423__F2 Differentially expressed genes in the proteasome pathway CS ING1 RPA1 POMP RPN2 PMC4111284__F1 IGF signaling pathway SST IGF1R IGF1 IGF2 GHR GHRHR IGFALS IGF2R GHRH PMC6700399__F1 Inflammatory pathway centered upon TNF in the process of NASH-HCC development STAT1 TLR4 TNF ROS1 STAT3 PMC6023281__F3 Neuroprotection and the PI3K/AKT/PTEN/GSK-3B pathway and SODs MAF GSK3B PTEN PMC5801575__F5 Proposed biosynthetic pathways of Cat315+, Cat316+ and WFA+ aggrecan CS OTX2 GAL PMC7886076__F4 PTEN signalling in other major oncogenic pathways PTEN FURIN PLAC1 PMC3735949__F4 Comparison of the gene expression and eicosanoid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the arachidonic acid metabolism pathway PLA2G4B PLA2G6 CTRL PTGS2 PTGES ALOX5 PLA2G5 PTGS1 PMC2768990__F2 BANs of differentially expressed genes in common between cell lines LIPG DHFR CADPS2 SLC26A2 FGF19 FXYD3 SSBP2 GLIPR1 PIK3R3 IFI16 TAGLN PMC3735949__F5 A comparison of gene expression and lipid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the sterol biosynthesis pathway SQLE SOAT2 CH25H DHCR7 CTRL SC5D DHCR24 HMGCR PMC5801404__F2 Mechanistic map of the signaling pathways involved in local translation mediated by class I mGluRs in neurons EEF2K PC GRIP1 MAP1B GSK3B ARC EIF4E DGKK MTOR PMC9152184__F2 Update in TIGIT Immune-Checkpoint Role in Cancer TIGIT CD226 IRF4 GATA3 FOXP3 PMC3735949__F6 Changes in the genes and processes related to mitochondrial metabolism in RAW264.7 and TGEM cells treated with KLA CLYBL CPT2 PMC198547__F8 Leptin action on the TRH neuron POMC NPY AgRP MC4R STAT3 PMC2908768__F4 Cytokine signaling through the Jak/Stat pathway in mammary gland development SOCS3 IL13 SAA1 IL4 OSM SOCS1 PRL OSMR PMC11655924__F3 High glucose in diabetes enhances Wnt-stimulated nuclear accumulation of Beta-catenin LEF1 APC LRP5 CCND1 LRP6 ARHA RYK ROR2 PMC3092522__F1 HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies IGF1R PTEN MTOR PMC11655924__F1 Anomaly of the insulin-signaling pathway TSC2 TSC1 GRB2 SHE RAF1 SOS1 MTOR IRS1 RHEB PMC5663718__F3 Periodontitis caused by defective killing of bacteria PLG CCR4 CCL2 PMC11655924__F2 Adrenergic signaling at the crossroads of diabetes, obesity, and cancer TRIB1 ADRB3 IRS1 ADRBK1 PMC6060254__F1 lncRNAs involved in the IFN antiviral response TBK1 CGAS RSAD2 IRF7 IFITM3 CMPK2 IRF9 BST2 IRF3 MYD88 TLR3 IFITM1 MX1 USP18 ISG15 OASL OAS1 GBP1 TLR7 TYK2 JAK1 MAVS IFI6 IFIT1 PMC8034148__F2 Regulatory mechanism of necroptosis RIPK1 TRADD CYLD RIPK3 FADD MLKL PMC7237193__F7 Regulatory network of let-7 is associated with the metabolism of glucose, fatty acids and amino acids in the silk gland TH PC CP PMC9502527__F2 Molecular Pathways of WRKY Genes in Regulating Plant Salinity Tolerance SOST MYC PMC11703377__F1 Remodeled fatty acid metabolism in tumor cells SCD EGFR VHL ACLY MTOR FASN HEL-S-5 PMC8222901__F2 Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity TBK1 TRADD TRAF3 TRAF6 IRF3 MYD88 RIPK2 TRIM39 NOD2 TRIM26 TLR3 TRIM40 NLRP3 TLR4 TRIM38 TRAF5 CACTIN TRIM27 TRAF2 RNF39 MAVS PMC3078523__F2 Heme Oxygenase-1, a Critical Arbitrator of Cell Death Pathways in Lung Injury and Disease BAD BAX PMC3953959__F6 Regulation of TFs activity by degradation modulated by H2O2 KEAP1 ATM MDM2 TF PMC7248300__F2 HCMV encoded proteins which help to evade CD4+ T cell mediated immune responses CGAS MHC2TA PMC9507777__F4 Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma PDC IL6 PMC4941299__F8 Involvement of SULF2 in Gamma-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression SULF2 STAT3 PMC8120474__F8 Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis NFATC1 GSK3B PMC5437908__F2 Predicted synthesis pathway for the t6A modification and its derivatives in H CDKAL1 GON7 YRDC TRMO PMC5911724__F5 PI3K–AKT signaling pathway MYB CHUK BAD PHLPP2 PCK1 GNB5 CSF3 CSF3R MYC BCL2L1 PTEN PDPK1 TNFSF6 PIK3AP1 MDM2 CASP9 CCND1 MAPK1 RBL2 CD19 FOXO3A CDKN1B CDC37 GYS1 RAC1 IRS1 BRCA1 CREB3 RXRA YWHAQ PPP2R3B MAP2K1 MTCP1 NFKB1 GRB2 BCL2 SYK CRTC2 MCL1 RAF1 AKT3 PMC6908429__F4 Tetherin blocks virus release, activates an innate immune response and is counteracted by Vpu or Nef CXCL10 TRAF6 SYK TRAF2 PMC7582160__F4 Details of unfolded protein response activation in the venom gland OS9 HEL-S-99n SYVN1 XBP1 AMFR ATF4 EIF2A SREBF2 SEL1L CD82 DDIT3 DNAJC3 HEL-S-125m CANX MBTPS1 INSIG1 CEBPZ DNAJA2 MBTPS2 ERN1 BCL2 VCP TRAF2 PPARG HEL-S-72p PMC4325158__F3 Transcriptomic changes in central metabolic pathways induced by pho13Δ during growth on different carbon sources HEL-S-49 ENO1 ADH5 tal-1 PMC6509240__F7 Working model of polyI:C-mediated protection on pancreases from inflammatory injuries CXCL1 IRF3 CXCL2 IL1B PMC11669671__F3 Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products MDP1 SORD TF PMC7465096__F8 “cooperativity model of MIP-1A amplification” in THP-1 monocytic cells TLR4 IRAK1 TRAF6 IRF3 MYD88 TRAF2 PMC10389819__F6 C-Phycocyanin Ameliorates the Senescence of Mesenchymal Stem Cells through ZDHHC5-Mediated Autophagy via PI3K/AKT/mTOR Pathway MSC ZDHHC5 MTOR PMC11669671__F6 BGCs and biosynthetic pathways of (A) amphichopyrone B (39) and (B) penilactone A (41) and B (42) AMPH COCH PMC7550695__F1 Molecular players involved in the NRF1 pathway USP15 NRF1 OGT NGLY1 PMC6854591__F8 PH-EPS modulates the activation of RAW264.7 cells through the TLR4(Dectin-1)/NFKB/MAPK pathway MYD88 TNF TIRAP PMC10531730__F1 Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications TSC2 TSC1 IGF1 IRS1 RHEB PMC5085738__F4 Schematic model of drought responsive proteins involved in photosynthesis, carbon metabolism, fatty acid metabolism, and nitrogen and amino acid metabolism CS PC NONO AGXT HEL107 RPE AMT HPR HEL-S-162eP PMC6755737__F1 The central carbon metabolism of C PTS PMC10741690__F2 Mitophagy pathway PINK1 FUNDC1 AMBRA1 BNIP3 OPTN PMC11844033__F8 Graphical Abstract Under hypoxic conditions, JUN enhances the transcription of EGLN3, which subsequently binds to HUR to positively regulate the stability of EGFR mRNA EGLN3 EGFR JUN PMC5930795__F5 Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity FGF21 IGF1 ATF4 TRH STATH IRS1 GHRH PMC6856370__F9 Model of cross-talk between D2R and Wnt/Beta-catenin pathways, and Wnt3a transcriptional regulation WNT3A APC GSK3B LRP5 LRP6 PMC8708225__F1 Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia SOX2 LATS1 LATS2 PMC7366106__F8 TNF pathway modified from hsa04668 CASP3 MMP3 TRADD LIF TRAF3 IL6 TNF TRAF2 FADD MLKL SELE ITCH PMC9523645__F7 SARS-CoV-2 Nsp6-mediated disruption of glycolysis HEXA MAX MYC GCK PCGF6 TFDP1 MGA PMC5590720__F1 Modes of action of Abatacept/Belatacept and anti-CD28 domain antibodies APC CD80 PMC4950965__F2 Targeting the RB-E2F pathway in breast cancer MYC CDK4 CDK6 PMC3887071__F2 Synthesis and Biological Properties of Fungal Glucosylceramide C9 C7 C6 PMC2680291__F1 Illustration of some of the key enzymes involved in the metabolism of methotrexate (MTX) GGH FH DHFR TYMS HEL-S-70p ABCG2 FPGS SLC19A1 PMC3566151__F1 TGFB and TGFB/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts SMAD2 SMAD4 PMC7116212__F6 Ribosome biogenesis pathway showing genes which are significantly changing upon sodium azide treatment of wild type cells UTP6 UTP4 IMP3 NMD3 IMP4 PWP2 UTP18 LSG1 EMG1 NHP2L1 TCOF1 DRG1 NOP56 DKC1 NHP2 UTP15 GAR1 RAN NOP58 BMS1 NOP10 NOB1 POLI PMC9500434__F8 Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration VCAM1 HEL-S-15 CDH2 PMC6844627__F4 Mapping Biological Networks from Quantitative Data-Independent Acquisition Mass Spectrometry Proteomic Data: Data to Knowledge Pipelines UBC ENO3 LDB3 HEL-S-101 HEL113 HSPD1 CLIC4 DUSP3 CYCS TNNI3 HEL-S-162eP PMC8908968__F2 Genetics and Epigenetics of Parathyroid Carcinoma APC LRP5 LRP6 EZH2 WT1 AXIN2 DKK2 HIC1 CDC73 PMC4451040__F2 Back from the dead; the curious tale of the predatory cyanobacterium Vampirovibrio chlorellavorus CS AEN APC C6 IPP PMC4023818__F10 Working model TSC2 TSC1 RPS6 PER1 PMC7357070__F3 Toll-like receptor signaling pathway includes the highest number of the proteins identified, related to immune system pathways and appearing in both SARS-CoV-2 and HIV-1 infections CD14 CTSK TLR9 LBP IRAK4 RAC1 FADD TIRAP CPO PMC12076214__F3 Multifunctional cytochrome P450 orchestrates radical cleavage and non-radical cyclization in 5-oxaindolizidine biosynthesis† SP2 SP3 PMC8115730__F2 Mechanisms controlling pancreatic islet cell function in insulin secretion HEL-S-26 PC SENP1 CIC HEL-75 ACLY PMC3262193__F3 Signaling pathways and proteins that increase or decrease STAT5 signaling in normal mammary epithelial cells EGF PAK1 ERBB4 ELF5 TGFA PRL PMC10706414__F1 Interleukin (IL)-37 maintains its anti-inflammatory outcomes by limiting IL-18RA from adhering to IL-18 and by attracting the orphan decoy IL-1R8 to the IL-18R/IL-37/IL-1R8 complex NLRP3 FYN PTEN MYD88 MTOR STAT3 PMC7817290__F1 The effects of hypoxia on BMSC senescence MTOR PMC8614808__F4 TRAP1 in Oxidative Stress and Neurodegeneration ELF2 ATF4 EIF2A CDH2 STAT3 PMC8505617__F6 The TGFB signaling pathway and the interaction between lncRNAs and the pathway SMAD2 TGFBR1 TGFBR2 SMAD4 TF PMC8505617__F5 The Hedgehog signaling pathway and the interactions between lncRNAs and the pathway SUFU PTCH1 GPR161 SMO PMC3995050__F1 The PI3K/Akt/mTOR pathway TSC2 RICTOR BAD TSC1 PDK2 MDM2 PTEN MTOR RHEB PMC8326207__SF2 Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions EPHX3 CERS3 WAS TG SDR9C7 CYP4F22 PMC8505641__F4 Mechanisms involved in the modulation of inflammation by miRNA derived EVs NLRP3 IRAK1 SRC IRAK4 PTEN MYD88 STAT3 PMC4943346__F1 Destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma APC PMC5655313__F4 Role of growth differentiation factor 11 in development, physiology and disease WFIKKN1 GDF11 FSTL3 PMC8218521__F1 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy MUC1 CD80 GAL CD19 PMC8218521__F2 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy SLC35B4 NAGK SLC5A1 TSPAN31 GMDS C18orf45 FCSK GCK DPM2 CMAS SLC35A1 PMM1 ALG3 SLC35A3 GAL GMPPB NANP HK2 GNE PGM3 ALG13 MAN2A1 UGDH MGAT5 MGAT1 GFPT1 DPM3 DPM1 FUT8 MGAT2 PMC9169372__F7 Targeting type IG phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer RAD50 MRE11A BRCA1 PMC6397541__F7 AhR−AREG axis defines a signaling pathway between cellular intrinsic redox mechanisms and surrounding TME CXCL1 AHR AREG CXCL5 EGFR VEGFA CCL5 CXCL2 CCL2 PMC8699227__F7 Cell Cycle Progression by Growth Factor-Induced Cell Signaling CDK4 PTEN PMC8699227__F8 Cell Cycle Progression by Growth Factor-Induced Cell Signaling BAD PTEN PMC11659109__F3 Triggers for postnatal metabolic shift HIF1A GLA UCP2 PMC4357026__F8 Diagram depicting the possible activation of TM detoxification of xenobiotics CD14 TLR4 ABCB1 PMC3762301__F3 Molecular inhibitory mechanism of cPAP to block proliferation and survival of prostate cells ERBB2 H1-2 RAF1 PMC3739039__F3 Integrated “omic” analysis reveals global metabolic changes UMPS HEL-S-70p HEL107 PMC12205135__F3 Molecular mechanisms of peripheral sensitization in cancer pain BDKRB1 BDKRB2 CCL2 TRPV1 PMC12205135__F5 Glia-neuron interplay drives central sensitization in cancer pain CXCL1 CXCR4 IL8RB CXCL12 PMC9490723__F1 Proviral role of caspase-6 IRF7 ATF4 EIF2A IRF3 MAVS PMC6335100__F2 Mechanistic target of rapamycin (mTOR) signaling network NF1 ULK1 TFEB SLC38A9 ATF4 GRB2 CASTOR1 PTEN IRS1 RHEB PMC4636073__F7 T cell receptor signaling pathway showing downstream mediators regulated by DNA methylation, gene/protein expression and/or protein phosphorylation MAPK9 MAPK3 GSK3B NRAS PDPK1 NCK1 IFNG ITK FYN BCL10 MAPK1 ICOS FOS VAV1 MAP3K7 CTLA4 HRAS PAK1 GRB2 MAP3K14 LAT NFKBIE CDC42 PLCG1 IKBKG CHUK NCK2 LCP2 IL2 CDK4 IL4 CD3G JUN CD3E IL10 CD3D NFATC1 MAP2K2 ARHA IL5 CBL IKBKB CARD11 NFKBIA NFKBIB MAP2K1 NFKB1 PTPRO LCK RELA GRAP2 ZAP70 MAP3K8 RAF1 SOS1 PDCD1 PMC5216784__F10 Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1A and PERK pathways ATF4 XBP1 PMC8262610__F2 Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis BTK NFATC1 OSCAR TEC TRAF6 SYK PMC5334358__F1 Necrototic pathway HMGB1 SAP130 TRADD TRAF5 CYLD S100A9 TRAF2 FADD PMC9277014__F1 Roles of TNF Signaling Pathways in Metabolism of Bone Tumors TRADD TRAF2 FADD PMC5343756__F1 A Critical Evaluation of Neuroprotective and Neurodegenerative MicroRNAs in Alzheimer’s Disease AGO2 DROSHA RAN PMC6770144__F1 HER2 signaling pathway CDK2 FOS MYC MDM2 CCND1 CDK4 PTEN MTOR JUN CDK6 CCNE1 PMC6770144__F2 Mechanism of TRA/GO action TRADD TRAF5 TRAF2 FADD MLKL PMC8002821__F3 Classical NFKB (Right) and STAT3 (left) activation pathways HGF RELA TRAF3 UNK MTOR TRAF2 STAT3 PMC12089637__F7 Proposed mechanism of LRRC56 regulation BC progression via RhoA/ROCKs axis YAP1 HEL-S-15 LRRC56 ARHA PMC7792434__F1 IL-39 and signaling pathway STAT1 EBI3 IL23R STAT3 PMC3579806__F4 Differentially Expressed miRNAs after GnRH Treatment and Their Potential Roles in FSH Regulation in Porcine Anterior Pituitary Cell EGF GNRHR MMP14 MMP2 EGFR GRB2 SRC FSHB TF CDC42 PMC6125400__F4 Simplified KEGG pathway “Proteoglycans in Cancer” with H3K4me3 and H3K27me3 enriched genes PLAUR MAP4 MAPK4 ARHGEF12 MYC ARHA PS1TP5BP1 PMC9166240__F6 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy CD47 LRRK2 RUNX2 SMAD4 ARHA MTOR DOK1 TLR7 IGF1 MMP12 GAB2 ZAP70 STAT3 PMC11745089__F2 Relationships between gut microbiota, gut microbiota-associated metabolites, and EGFR/VEGFR/KRAS pathways EGF NRP1 EGFR SP1 MTOR PMC9166240__F8 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy MYD88 STAT3 PMC9011113__F3 Myth of cobra venom cytotoxin: More than just direct cytolytic actions CASP3 HSP90AB1 ATF2 NOX4 ENG PMC2707240__F2 Proposed model for As2O3-dependent activation of the mTOR pathway in a negative feedback regulatory manner in malignant cells EIF4E RPS6 MTOR EIF4B PMC3466441__F1 Peptide neuromodulation in invertebrate model systems PDF EN2 EN1 PMC6244318__F1 KEGG insulin signaling pathway identified by WebGestalt from the bta-miR-486 target gene list TSC2 BAD GRB2 INS EIF4E FOXO1 INSR PMC6617290__F1 Model that proposes the form in which physical activity activates the nuclear factor erythroid 2-related factor 2 (Nrf2)–Keap1 pathway MAF KEAP1 PMC7140412__F2 The autophagy molecular pathway and target steps of its modulation ATG12 ATG3 AMBRA1 ULK2 UVRAG MTOR ATG14 FOXO1 RHEB PMC6617290__F2 Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise TSC2 EEF2K USF1 NRF1 IGF1 MTOR SIRT1 PMC4111995__F2 Molecular insights into NF2/Merlin tumor suppressor function AMOT PALS1 LATS1 LATS2 PMC8115215__F8 PSA regulatory mechanism of VRC metabolism CYP2C19 TRAF6 MYD88 IL1B PMC4356644__F1 BiP and its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions SEL1L SIL1 PMC5732750__F6 CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer GDF15 SP1 CXXC4 PMC2953915__F7 Model of E2F2-mediated regulation of the Ahr pathway FAN1 AIP AHRR AHR E2F2 PMC8505617__F1 The canonical Wnt/Beta-catenin signaling pathway and the interactions between lncRNAs and the pathway APC GSK3B LRP5 LRP6 PMC2667932__F1 Model for TGFB1-induced PAI-1 expression SMAD2 EGFR SMAD4 RHO PMC9456094__F2 PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review APOE TGFBI PMC6313860__F2 CLV-WUS signaling pathways in model and crop plant meristems SI FOS PMC3794713__F1 Simplified overview of commonly mutated oncogenes, tumor suppressors, and pathways in endocrine cancer NF1 RET BRAF MAX MYC VHL TMEM127 PMC5217521__F2 Oncogenic mutations for the upregulation of EREG expression.Notes: Oncogenic mutations in the EGFR, KRAS, or BRAF genes result in activation of the MEK/ERK signaling pathway, which in turn upregulates EREG expression EREG ERBB4 BRAF PMC6812587__F2 Macrophage function by polyamine synthesis ARG2 SMOX SRM NOS2 ARG1 DKFZp686F0183 SMS PMC6755139__F3 STRING connectivity network demonstrating a protein–protein interaction network of predicted functional partners for differentially expressed genes in the brown module UQCRB HEL-S-134P RILP OPTN IGF2BP2 DPM2 TFR2 EPB42 MAF CMAS USP12 FECH TPGS2 DCAF12 NUDT4 TRAK2 DPH3 KAT8 ZMAT2 SERF2 HAGH TESC RPIA RPL26 ABCG2 GABARAP SNX1 SNCA TXNRD2 RIOK3 RPL30 RGCC DNAJB2 DNA2 CDC42 PMC4853920__F3 Alternative pathway is constitutively active at low levels through the hydrolysis of the thioester in C3 to C3(H2O) HEL-S-62p FH C6 PMC4703717__F1 Synthesis and immunomodulatory effect of gangliosides CD40 CD80 GAL ST8SIA1 PMC1237076__F7 Wnt-NLK pathway inhibits the activity of Myb family of proteins by two different mechanisms NLK HIPK2 WNT1 MAP3K7IP1 PMC10946266__F6 MgH2 protects against APAP-AKI by inhibiting TXNIP/NLRP3/NFKB pathway NLRP3 BAD BAX PMC2699768__F3 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism AHR PLG SP1 LTBP1 PMC5359838__F5 Schematic representation of the opposite p53-TRIM8 and N-MYC-miR17-5p/miR106b-5p networks in cellular response to treatments TRIM8 PMC2699768__F1 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism EGFR GSK3B PMC6888570__F2 Canonical KEAP1/NFE2L2 antioxidant signalling pathway, induced by electrophilic ligands KEAP1 NFE2L2 RBX1 PMC4584279__F3 Selected signal networks induced by Dectin-1 and Dectin-2 COX2 CARD9 PC BCL10 EGR2 HEL-S-11 CCL20 GRB2 RELB SYK PLCG2 RAF1 PMC4317086__F1 Figure can be read from the upper-left corner in an anti-clockwise direction HEL-S-2a RHAG PMC2677203__F7 Signaling via the TgfB type I receptor Alk5 in heart development RUNX2 AK3 NFATC1 SMAD2 ARHA DKFZp781O1323 PMC10970480__F3 Potential mechanisms by which exercise intervenes in insulin resistance through mitochondria-associated membranes MFN2 FUNDC1 MCU TG FIS1 PMC7340521__F7 Dual RNA-seq provides novel insight into the roles of dksA from Pseudomonas plecoglossicida in pathogen-host interactions with large yellow croakers (Larimichthys crocea) CXCL1 SOCS3 TRADD CX3CL1 TRAF3 CXCL3 NOD2 MMP3 CSF2 CASP8 SELE LIF MMP9 CXCL10 CXCL2 IL6 TNF CASP10 MAP3K7IP1 IL15 EDN1 MMP14 LTA TRAF1 CSF1 TNFAIP3 TRAF2 FADD MLKL IL18R1 ITCH TAB3 PMC10970480__F2 Lipid metabolism-related proteins and pathways involving mitochondria-associated membranes DGAT2 SCD CYP11A1 CYB5R3 TG PSD PBR PMC3794713__F2 mTOR and MAPK pathways TSC2 TSC1 GRB2 PTEN RHEB PMC5922385__F8 Model of miR-652-mediated mechanism of EMT in PC3 cells PMC8829035__F9 Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways KEAP1 PIR INS NQO1 PMC5859169__F4 Alzheimer’s disease pathway and enriched gene ontology with Down-regulated genes MAPK9 PPP3CA MAP2K4 UBE2G1 MTOR NAE1 HEL-S-44 MAPK1 GNAL COX7B NDUFB6 NDUFB5 DCTN4 COX7A1 SNCA SLC17A7 SLC17A8 NDUFV2 POLR2K RTN3 NDUFA7 DNM3 SYT10 NDUFAB1 NDUFS3 RAC1 COXFA4 SNAP25 VDAC3 SLC25A4 NAPA SYT1 CALM1 PPP3R1 UNC13A CYCS CDC42 PMC3871865__F1 Photoreceptor cell death and rescue in retinal detachment and degenerations CASP3 NLRP3 IL18 CASP9 CASP8 FADD PMC8274179__F1 Cell death as part of innate immunity: Cause or consequence? IL18 MPO RIPK3 BAX PMC3760899__F3 Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation CDKN1A AREG MEN1 GADD45A SPHK1 GC20 NAT14 BCL2L2 BAX TSPYL5 PMC9615247__F1 STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy EGF HGF IL9 CXCL10 CCL5 TNF IL23R CCL1 AHR MMP2 MCL1 TGFA IRF4 SOCS1 STAT3 PMC5316362__F2 Ingenuity®Pathway Analysis (IPA®) revealed significant overlap between the XDP signature and gene networks related to (A) RNA polymerase II (p = 1.19 × 10−6) and (B) NFKB (p = 1.36 × 10−12) ANGPT1 HOXA11 MAP2K1 MAP2 HOXA10 PMC7817929__F3 Molecular Features of the Serrated Pathway to Colorectal Cancer: Current Knowledge and Future Directions ZNRF3 MCC RNF43 BRAF HP AXIN2 PMC4150760__F3 Inferred non-small cell lung cancer pathway using the SpliceNet and RNASeqNet EGF BAD BRAF ERBB2 EGFR GRB2 TGFA PMC4246201__F10 Relationship between GPxs and the NFKB pathway in the antiproliferation action of butyrate GPX3 GPX4 VCAM1 PMC6610297__F7 Metabolic pathway of glycerophospholipid, glycolysis, and TCA cycle under hypoxia stress HEL-S-26 CDS1 PC PGP LPA PMC4824143__F1 Smad and non-Smad transforming growth factorB1 (TGFB1) signaling pathways SMAD2 ATF2 SMAD4 MAP3K7IP1 TGFB1 PMC3464294__F4 Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells SMAD2 MTOR MMP7 PLAT MDM2 LIMK2 LIMK1 PLAUR NCL PLG HEL-S-28 VAV1 LRP5 VEGFA SHE ARHA DOCK1 RAC1 EIF4E HRAS WIF1 MAP3K7IP1 CRK NLK PAK1 VTN GRB2 FRAT1 PMC6458850__F6 The role of CXXC5 and molecular mechanism of KY19382 in longitudinal bone growth CXXC5 GSK3B PMC2673912__F6 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation PLK1 APC VEGFA GADD45A BRCA1 TCP1 CDR2 CDC20 ATM CDK2 RELA MDM2 RAD50 ORC1L CDC2 GTSE1 FANCG PMC2673912__F8 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation EGR1 NR1i1 MAX EBP CREB1 CEBPA SP1 PMC11396801__F1 Selection of Reference Genes in Siraitia siamensis and Expression Patterns of Genes Involved in Mogrosides Biosynthesis MVD MVK GLA PMC8911477__F3 Dysregulation of mTOR Signaling after Brain Ischemia TSC2 TSC1 IGF1 BDNF RHEB PMC6255979__F2 Non-canonical mechanisms whereby betaine inhibits IL-1B production NLRP3 CARD9 IL1B FADD PMC4248710__F13 KLF4-dependent miRs cooperatively promote RAS-ERK pathway activity by cotargeting of pathway inhibitors NF1 GRB2 SPRED1 SPRY1 PMC4037835__F1 The MDC–MMSET–UBC9–53BP1–BRCA1 pathway MDC1 PIAS1 BRCA1 PMC8699127__F4 Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm BMP2 APC LRP5 SMAD4 LRP6 SMAD1 PMC6615683__F6 Model describing the putative mechanism of synergetic interaction between PFK158 and erlotinib in WT and mutEGFR NSCLC cell lines EGFR CREB1 PMC5900789__F1 IL-10-mediated modulation of myeloid cells CD14 HLA-G SOCS3 IRF3 MYD88 STAT1 TLR4 NFIL3 TYK2 CD80 JAK1 IL10RA TF GPNMB STAT3 PMC6178360__F5 Metastatic adrenocortical carcinoma NCOR1 STOM EIF2AK2 ADCY3 CREBBP ERBB4 RBP3 EP300 NR1B3 ATM NCOA1 NCOR2 STAT3 ADCY9 PMC10930675__F8 RUNX2 and CXCR4 effects on melanoma cells RUNX2 CXCR4 MTOR PMC8579759__F4 Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma SMAD2 SMAD4 PMC11656958__F7 Schematic diagram depicting that STING exerts antiviral innate immune response by activating pentose phosphate pathway TBK1 UBE3A CGAS IRF3 HEL107 PMC6071809__F6 Proposed signaling pathways implicated in the promoter-specific expression of CYP19 in Hs578t cells MAPK3 MAPK1 STAT3 PMC7779984__F2 Omega 3 Fatty Acids and COVID-19: A Comprehensive Review TLR4 TRAF6 MYD88 MAP3K7IP1 PMC7033213__F3 Top causal network explaining observed gene expression differences CASP3 NFKBIA EGFR PARP1 HIF1A CASP8 TXN HEL-S-162eP PMC5989395__F2 Working model of the role of lysophosphatidic acid (LPA) at the maternal-conceptus interface in pigs ENPP2 PTGS2 LPA LPAR3 PMC4521627__F3 Integrating physiological regulation with stem cell and tissue homeostasis PRDM16 VHL BMI1 PTEN PMC6003554__F2 Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population CHEK2 ATM ATR PMC5630004__F2 Drug targets on the TGFB signaling pathway SMAD4 TF PMC7750395__F9 Graphic abstract of IAV-induced acute lung injury HMGB1 TLR4 MPO PMC5630004__F1 Context-dependent transforming growth factor B (TGFB) signaling outputs arise from pathway interactions EGF SMAD4 TNF TGFA TF PMC3114084__F2 Titin domain arrangement in the cardiac sarcomere and connectivity within a mechanical signaling network FHL1 FHL2 NBR1 PMC8447269__F2 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia SUFU SMO PMC11984845__F8 Proposed model integrating multi‐omics data of FIIN‐2 highlights the regulatory network of downstream and involved signaling pathways TSC2 TSC1 PIP4P2 FRS2 EGFR BCL2L1 MTOR EPHA2 TF STAT3 PMC7947698__F1 The Wnt signaling pathway in transgenic mice APC GSK3B DKK1 PMC8447269__F1 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia DHH IHH SUFU PTCH1 SHH SMO ADRBK1 PMC7178546__F1 Signaling Model from CAR Antigen Binding Through ERK Activation, Incorporating Models from literatureArrows and bars indicate activating and inhibitory interactions, respectively ITK CD37 CSK LCK GRB2 LAT CD19 PMC4426444__F2 Reconstructed metabolic pathways in the common ancestor of apicomplexans and dinoflagellates at the time of plastid gain (A) and in Hematodinium sp FES DAP IPP PMC11629464__F1 MiRNA regulation of apoptosis and autophagy in Mtb-infected macrophage CD14 BAD FOXO3A IRAK1 TRAF6 IRAK4 MYD88 TNF MTOR MAP3K7IP1 FOXO1 RHEB IFNG BCL6 STAT1 TLR4 TFEB TIRAP SOCS1 BAX PMC6691526__F2 Impact of ovarian cancer-exosomes on target cells during pre-metastatic niche formation ATF2 MMP9 CD44 STAT3 PMC10381003__F2 The TLR signalling pathways with highlighted gene polymorphisms involved in OA susceptibility TLR8 TLR5 TLR7 TLR4 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 PMC2677410__F2 Novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell TSC2 PML TSC1 PTEN MTOR RHEB PMC7717626__F1 Identity and the heterogeneity of extracellular vesicles and exosomes CD9 CD63 CD81 PMC10533046__F3 Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast IPP UGT1A1 PMC11012607__F4 Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review ELOVL1 ELOVL5 ELOVL3 ELOVL2 TNF PMC3174190__F2 Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children RPS17 RPL41 SART3 KLRC3 CNBP EEF1E1 PC4 MAGOH MAGEA4 RPL3 DGKA PMC10179295__F2 Paxillin participates in Wnt, integrin-FAK, and TGFB signaling pathways FYN SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA PMC10179295__F3 Paxillin participates in MAPK and PI3K/AKT signaling pathways PTPRT EGFR CCND1 SRC PMC6513850__F8 Diagrammatic model summarising the proposed bimodal Wnt signalling regulation by DYRK1A, as reported in Figs – APC DYRK1A PMC8156652__F9 Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles GSK3B GRB2 PTEN PMC3430470__F5 The role of Monosaccharide Transport Proteins in carbohydrate assimilation, distribution, metabolism and homeostasis HEL-S-62p GAL PMC7875919__F2 Lipid metabolism by the unfolded protein response DGAT2 INS CPT2 LPA TG MTTP HMGCR PCSK9 LPIN1 CHKA ELOVL4 LDLR PECR CHKB ACLY PMC9623391__F1 Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease SPR HEL-S-90n KYNU KMO PMC6173648__F6 A hypothetical pathway that may underlie vibration-induced changes in gene transcription in the prostate PMEL IL16 BARD1 PMC6885365__F4 Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis NANS ACADS DES LMNA PMC3396054__F3 TGFB activates Smad 2/3 and Smad1 pathway SMAD2 SMAD1 CTGF PMC8710701__F8 Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis STAT1 PIM1 SOCS3 CDK2 MMP9 CEBPA JAK1 CEBPB STAT3 PMC4722119__F1 Regulation of fatty acid synthase by O-GlcNAcylation, Terra incognita OGT TPR PMC4425321__F1 General scheme, illustrating BDNF-TrkB signaling through three main pathways in the neuronal cell (NC).Notes: PLCG pathway results in activation of neuronal plasticity and long-term memory formation via PKC, TRPC, and transcriptional factor CREB GRB2 MTOR BDNF BAX PMC4425321__F2 Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness TRAF6 BDNF CDC42 PMC9339642__F1 Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers YAP1 EGFR APC BRCC3 PTEN LATS1 MTOR IRS1 FBXW7 FOXO1 HMGA1 ZEB2 GC GALNT3 TUBA4B SIRT1 BCL9 HOXB13 ST6GAL1 STAT3 PMC8178780__F1 Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation TLR4 CR2 STAT3 PMC4269194__F1 Spatiotemporal regulation of feeding response by O-GlcNAcylation OGT GSK3B IRS1 PMC11866848__F6 Research progress of disulfidptosis in the TME KEAP1 SLC7A11 ATF4 PMC11866848__F7 Relationship between disulfidptosis-related pathways and ICIs EGR1 RAC1 IRF4 HK2 GLS PMC11866848__F4 SLC7A11 inhibiting ferroptosis in cancer cells GPX4 SLC7A1 ALOX12 PMC7937699__F2 From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past CD80 MTOR PMC7010683__F8 Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1 HGF MTOR PMC6023766__F4 Apoptosis signaling pathway and its control by phosphorylation BAD BIK BMF HRK BAX PMC11672879__F3 Protective mechanisms of phytochemicals in AMD GCLM GCLC SIRT1 NQO1 BAX PMC5963348__F7 Schematic model for SIRT3-induced autophagy and its underlying mechanism in SH-SY5Y cells following rotenone treatment MTOR ROS1 SIRT3 PMC9354605__F3 Landscape of chimeric antigen receptor T cell therapy in breast cancer: Perspectives and outlook CD27 ICOS PMC6023766__F2 Control of the PI3K and RAS signaling pathways by phosphatase signaling PDK2 GRB2 PTEN PMC8748692__F9 Proposed model for ER-stress-induced AR decrease ELF2 ATF4 PMC8291901__F2 Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment PGC ABO SIRT1 PMC6015598__F2 Dysfunctional cellular mechanisms in PD VPS35 SNCA RAB1A LRRK2 TFEB DNAJC6 PMC2922045__F1 TLR AGONISTS: Are They Good Adjuvants? TBK1 CD14 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 TIRAP PMC7320018__F6 Possible roles of TBC1D9 (A) and MFGE8 (B) MFGE8 SEL1L OS9 TWIST1 HIF1A STAT3 PMC5461634__F3 Sub-network of cell cycle pathway regulated by C1orf132 and TMPO-AS1 WEE2 CCNA2 E2F4 GSK3B MYC RB1 TFDP1 CDKN2A E2F3 CDK6 CCNE1 SMC1A WEE1 RAD21 ANAPC1 CDKN1B E2F5 GADD45A CDC25B CDKN1C CDC45 STAG2 MCM3 MCM5 CDC20 MCM6 MCM2 CDKN1A CDKN2B CDC6 CDK2 ATR PCNA SFN TTK CDKN2D CDKN2C CCNH TFDP2 CCND3 DBF4 MAD1L1 ORC3 ORC2 CDK7 CCND2 CHEK2 GADD45B E2F2 CCNB1 CCND1 CDK4 RBL2 RBL1 CCNE2 GADD45G ANAPC2 MAD2L1 STAG1 CHEK1 PTTG2 CCNB3 SMC3 CCNB2 CDC26 SMC1B SKP2 ESPL1 ANAPC10 PMC11467144__F2 WNT signalling pathways in the intestinal crypt and potential therapeutic targets ZNRF3 RNF43 APC LRP5 LRP6 PMC2885591__F2 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging TSC2 RIN1 AMPH MTOR RHEB PMC10540641__F9 Schematic representing the manufacturing process of a targeted delivery system MMP2 CD44 PMC6385430__F8 Suppression of WNT2 in signaling pathway GSK3B LRP5 BAX PMC7341846__F5 Alterations to the kynurenine pathway in RCC IDO1 HAAO NAMPT KYAT3 HEL-S-90n KYAT1 KYNU KMO AFMID IDO2 TDO2 PMC7613831__F4 DMT induces a transcriptomic signature promoting FAO and opposing fibrosis in the renal cortex of ZDF and ZDSD rats PC ACAN PPARG EHHADH NR1C1 CITED2 ACOX1 PMC9339518__F1 NAD+ redox balance, consumption and synthesis NAPRT HAAO NAMPT HEL-S-90n KYNU KMO AFMID PMC5835334__F7 Schematic diagram shows that TM suppressed the secretion of NO, TNFA, and IL-1B by reducing the bioavailability of copper and the activity of its downstream ROS/TRAF6/AKT/NFKB signaling pathway TRAF6 MYD88 IL1B PMC2885591__F1 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging TSC2 TSC1 VHL DEPTOR IRS1 RHEB MLST8 PMC11467144__F7 Summary Chart EGF ANGPTL2 BMPR1A IL33 KLF4 GPR49 MMP17 PMC11467144__F5 EGF signalling pathways in the intestinal crypt and potential therapeutic targets EGF IL33 HBEGF PMC6751629__F8 The role of Asc1 in translation initiation ELF2 ELF3 EIF3A RPSA PMC9264948__F10 Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells UACA SOX2 BCL2 WT1 HIF1A RAB8B FADD PMC3986091__F3 Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice F10 HAMP CLEC4D RNF149 APOC2 ALOX5AP APOC1 IL8RB RHOV CXCL3 CLEC4E TNF PLA2G7 CYP26B1 LILRB4 S100A8 IL17A SAA2 RAB32 PMC6102093__F1 Schematic illustration showing mechanisms of smooth muscle cell (SMC) phenotypic switching MFN2 ACTA2 NOX4 CYB5R3 PMC7845653__F3 Podocyte Notch1 signaling in diabetic nephropathy (DN) SIRT6 NOTCH1 ARHA RHO PMC7533414__F5 GSDMENT switches apoptosis to secondary necrosis/pyroptosis CASP3 HMGB1 DFNA5 PMC7533414__F6 Gasdermins augment the mitochondrial apoptotic pathway CASP3 GSDMD DFNA5 PMC3115901__F4 The core biochemical network of the ceramide/sphingosine-1-phosphate rheostat CES1 GCLC SPTLC3 CERS5 FFAR1 PMC9322892__F2 Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic NLRP3 NLRP1 CRP IL33 IL-21 PER2 IFNG FOXP3 PMC3724896__F4 Differentiated Neuroprogenitor Cells Incubated with Human or Canine Adenovirus, or Lentiviral Vectors Have Distinct Transcriptome Profiles FANCD2 ATM BLM BIRC5 HEL-S-11 MAD2L1 RAD51 FAT2 PMC12106535__F6 The apoptosis-related gene/tumor-associated antigen MUC1 in mesenchymal stem cell-mediated treatment of IBD MUC1 GPX4 TLR4 LPCAT3 SLC7A11 MSC POR PMC3951765__F1 NLRP3 inflammasome activation: CD36 serves double duty TLR5 TLR4 CD36 PMC7506080__F1 Upregulation of AMH production in testicular Sertoli cells AMH SF1 GATA4 SOX9 SRY PMC9636637__F2 Iron metabolism in chronic diseases related to obesity PDX1 GPX4 SLC7A11 RP2 SLC3A2 PMC4069163__F6 Correction: De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response CD48 INTU CTLA4 CBL ITK FYN BCL10 LCK ZAP70 GRB2 CDK4 LAT ICOS PMC6950413__F1 Summarized natural and heterologous pathways for beta-carotene production investigated herein PMVK IPP PMC7854849__F1 Model indicating roles for MLH proteins in meiotic recombination DMC1 RAD51 SIX1 RMI1 MSH4 MSH5 SIX4 PMC6287006__F5 KEGG analysis of hsa-miR-210 target genes AP2A2 SMAD6 EHD3 RAB31 GIT2 EFNA3 ARF1 INPP5A SYNGAP1 E2F3 KIF5A CYTH1 PIK3R5 IP6K3 FGFR1 KSR1 ACVR1B MAPK1 CSF1 INHBB PMC9250975__F2 Ubiquitin Binding Protein 2-Like (UBAP2L): is it so NICE After All? SMAD2 CCNB1 PTEN CDC2 CDH2 SP1 UBAP2L PMC5457463__F3 Phosphoproteomic analysis of CCL2 treated DCs and confirmation of relevant signaling pathways GPSM1 FHOD1 ADD1 CCR2 ROCK1 IQGAP1 ARHA PLCG2 CCL2 CRKL CDC42 PMC9453003__F1 P38 MAPK Signalling in Testis Development and Male Fertility CYP26B1 RSPO1 WNT4 NANOS2 MAP2K6 SOX9 FGF9 SRY PMC7691587__F3 The mechanisms regulated by CMTMs in Hepatocellular Carcinoma EGF BAD HGF MMP9 EGFR MYC CCR4 CMTM7 CMTM8 CMTM3 MMP2 CMTM5 CMTM6 CMTM2 BCL2 CDK4 CDH2 STAT3 PMC6505517__F4 Interaction mapping of overlapping proteome changes in astrocytes treated with GBM a -stem and b -diff EVs FLNA MYC HEL-S-99n RPSA IGF2BP2 PAH CDK6 LMNB2 MAP4 IKBIP COX6B1 STRAP PSMC4 PFDN2 HSD17B4 LMAN1 CALD1 PDAP1 IMMT HEL70 ARCN1 P4HA2 HEL-S-107 PSAP ARPC4 TCP1 RICTOR STT3A CTNND1 SLC3A2 VCP TGFB1 HEL2 TPM1 ACTN1 HADHB EGFR TPM3 CFL2 LRPPRC HEL-S-128m PDLIM4 HEL-S-2a HEL-S-67p APP CDK4 KRT1 KRT10 RPL13a NFE2L2 SKP1 FUS RPS25 RPS17 ERBB2 APRT RPL10 PMC7890213__F2 Nrf 2 pathway as a target in different neurodegenerative diseases HTT GSK3B IL7R PMC3233287__F2 Illustration of main mechanisms of trastuzumab resistance (in red) and targeted agents to circumvent resistance (in blue) TSC2 TSC1 IGF1R GRB2 PIK3CA PTEN PMC4936551__F1 Proposed scheme to describe how are interconnected with Ca2+-pH signaling components in polar growing cells TH FER PMC5739026__F1 Three main classes of regulatory small RNAs AGO1 AGO2 DICER1 DROSHA PMC7890213__F1 Physiology of Nrf2 activation in both normal and stress conditions MAF KEAP1 PMC7785591__F1 Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway LRP5 HEL-S-44 LRP6 PMC9588473__F4 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach DKK3 SFRP1 DKK2 PMC9588473__F5 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach DKK3 GSK3B AXIN1 SFRP1 DKK1 DKK2 WIF1 DVL1 THY1 PMC9648670__F1 Interaction between gut microbiota and immune checkpoint inhibitor-related colitis VIT CRP IL1B PMC3243091__F2 Molecular control of palatal shelf growth and patterning OSR2 SHOX2 MEOX2 MN1 MSX1 BMP4 BMPR1A FGF10 SHH OSR1 EPHB2 BARX1 FGF7 PMC8698632__F3 Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome PCSK9 APOB PMC7589579__F2 Schematic representation of the endogenous and microbiota-associated pathways engaged in tryptophan breakdown in the gut environment IDO1 AHR PMC7335670__F7 IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer IQGAP1 PMC3442575__F4 Genes Involved in the Calvin Cycle and Photorespiration.(A) Schematic of the Calvin cycle and photorespiration pathway in C CS TAL2 SHMT1 HEL-S-51e GCSH HEL-S-68p PMC11126959__F2 Biosynthesis of O-GlcNAc TH NAGK PGM3 OGA AMDHD2 GNPNAT1 GFPT1 PMC11126959__F3 Autophagy pathway ULK1 ATG16L1 ATG12 MTOR SNAP29 DKFZp686F0183 CAMKK2 PMC11126959__F4 Impact of sustained changes in cardiac O-GlcNAcylation OGA OGT ATF4 REST SP1 MTOR RYR2 XBP1 PMC12178005__F4 Signaling pathways of diverse types of collagen affecting tumor progression by regulating tumor immunity STAT1 DDR1 COL3A1 CXCL5 LAIR2 LAIR1 TFAM SOX9 PMC12178005__F5 Signal ways of diverse types of HA affecting tumor progression by regulating tumor immunity CD44 PMC7186400__F5 Paraburkholderia sp HEL-75 C6 PMC12178005__F3 ECM remodeling facilitates the formation of immunosuppressive TME SPARC COX2 DDR1 TLR4 CXCR4 CCR7 CXCL12 DDR2 PMC7313051__F2 Graphical summary of biological factors influencing anti-tumor immune response constituting three categories depending on anatomical level: tumor cell, tumor microenvironment, and the whole body PTEN JAK1 B2M IFNG PMC9671658__F8 Glis1 and oxaloacetate in nucleus pulposus stromal cell somatic reprogramming and survival PC HEL-S-30 HEL107 PAH DLAT HEL-S-162eP PMC6160959__F5 Orlistat from PxEA perspective HEL2 PSEN2 MGLL LIPF PNLIP DKFZp686L0365 MAPK13 LPL GRB2 NOTCH1 ADAM10 HEL-S-93 FASN PMC9559691__F6 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress FLCN SLC38A9 GSK3B LRP5 INS TBC1D7 RNF152 LRP6 PTEN MTOR DEPTOR IRS1 RHEB TTI1 RICTOR GRB2 SLC3A2 GRB10 SKP2 PMC4398932__F5 Putative KF inhibition pathway in macrophage-mediated inflammatory signaling events TLR4 IRAK1 SRC SYK IRAK4 MYD88 PMC6698745__F2 Translesion synthesis REV1 POLE POLK SPRTN RAD18 PCNA USP1 POLI PMC5471801__F3 Enzymes involved in the metabolic pathway of PEB regimen ABCB1 UGT1A1 HEL-S-22 PMC9559691__F5 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress NLK CDK2 PDK2 MDM2 GRB2 INS SMAD4 PTEN SKP2 INSR STAT3 PMC7522758__F1 Circadian Dysregulation of the TGFB/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells CRY1 IMPACT SMAD4 TF PMC10610897__F7 Interaction network of genes and co-expressed lncRNAs involved in IAV replication regulation in MDCK cells STAT1 HCLS1 RSAD2 CLDN1 IRF9 TYK2 JAK1 HAX1 PMC8026947__F3 Unfolded Protein Response Pathway HEL-S-269 ATF4 EIF2A PDIA5 XBP1 PMC5363412__F1 Top Network Associated with the DERs Selected by the Criteria of 4-fold Change in Whole BloodThe functions related to this network are defined as cancer, organismal injury and abnormalities, and reproductive system disease E2F2 SMAD2 MYC CCND1 BCL2 TNFSF12 PKD1 NR1C1 GRHL3 E2F3 CCNO CCNE1 PMC6473842__F2 Signaling pathways in mDA neuron development ZNRF3 FZD3 PTCH2 DKK3 WNT1 LRP5 ETV4 FGFR3 LRP6 PBX1 GPR49 FGFR2 NOG LMX1A FGFR1 PITX3 PTCH1 GLI3 SHH SMO BDNF PMC6491942__F10 Schematic depicting the sensitization mechanism of CsA to crizotinib BTK TLR9 NFATC1 STAT3 KSR2 PMC8569340__F3 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy EGF BRAF EGFR PTEN MTOR IRF-1 IFNG BRD4 PMC2662467__F6 Cell proliferation and apoptosis NF1 PDGFRA DKFZp781B1423 ERBB2 EGFR MDM2 CDK4 PTEN RB1 CDK6 PMC8569340__F1 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy CIP2A PMC8569340__F2 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy PDPK1 PMC9637915__F6 Proteomics unveil a central role for peroxisomes in butyrate assimilation of the heterotrophic Chlorophyte alga Polytomella sp. PDC ACLY PXN PMC11234216__F3 Signal mapping of transcription factors regulating the fate of HPCs HNF4A SOX9 PMC8532163__F9 Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway CD14 TLR4 LBP MYD88 PMC5705877__F1 Biosynthesis of ceramide, sphingosine-1-phosphate, and ceramide-1-phosphate (a) DES SPHK1 CERK SPHK2 SMS PMC9295051__F3 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential COX2 AXIN1 CCND1 SP1 SOX9 TRIM65 INSR HMGA1 PMC9295051__F4 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential NOTCH1 EZH2 STAT3 HMGA1 BAX PMC11525935__F7 MiR-126 can inhibit the PI3K signaling pathway, promote M1 macrophage polarization, and suppress the activation of FAK and Rac-1, thus accelerating the progression of UUO CD163 MMP9 IRS1 PMC6446709__F1 Pathways for glycerolipid synthesis PC LPA PMC5550862__F8 Role of SDC-4 in the regulation of the integrin and FGF signaling pathways CDK2 CCND1 PMC12203119__F2 Intestinal immunity and microbiota in gut health TLR7 TLR4 TLR9 TLR3 PMC3949025__F11 Scheme depicting the inhibition of smooth muscle contraction via CB1 receptors RGS4 ARHA RHO PMC3601265__F2 Hypothetical pathways involved in MHC–self peptide-TCR recognition and PNH clone dominance IL10 TH IL15 IL7 IL2 TNF PMC9654040__F2 Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers CIP2A APC GC EGFR GSK3B SRC PMC6324070__F3 The MAPK (ERK) signaling pathway in the KEGG pathway map (hsa04010) where the main path from growth factor to ERK kinase is marked in pink NF1 EGF KIT DAO EGFR GRB2 KITLG CCND1 FAF1 PMC10453554__F1 Cyclin K-CDK12/13 complexes affect important biological processes and contribute to cancer development by phosphorylating different targets CDK12 BRCA1 PMC7425174__F2 PD-1-mediated immune regulation APC CD80 PMC3656449__F6 The pathway triggered by Tat and leading to activation of ISGs by Tat in APCs infected by HIV STAT1 IFI44 OAS1 APOBEC3A OAS2 IRF7 IRF3 PMC9424577__F6 An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products HMGB1 RIPK1 TLR4 ATM APAF1 APC EIF2A RIPK3 MLKL PMC5347023__F6 High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows TG NR1C1 PMC5451860__F1 Role of WNT/beta-catenin pathway on aerobic glycolysis in gliomas LRP5 LRP6 HEL-S-133P PMC5451860__F2 Opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in gliomas MYC HEL-S-133P PMC9513432__F3 How sphingolipids affect T cells in the resolution of inflammation CERS2 CERS6 HEL-S-5 PMC9513432__F4 How sphingolipids affect T cells in the resolution of inflammation IL10 IL6 MTOR FOXP3 PMC9074815__F4 Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System AMIGO3 SEMA3A RHO LINGO1 PMC6883319__F3 MetaCore-generated pathway of differentially expressed genes involved in protein kinase A (PKA) signaling PDE4D BAD AKAP8 AKAP12 AKAP11 PDE3A APC SMAD4 CREB1 PDPK1 NFKBIA NFKBIB PHKB HEL159 HTR1A PMC6883319__F4 MetaCore-generated pathway showing differentially expressed genes involved in sirtuin 6 regulation and function NRF1 ACACA HMGCS1 PTH ELOVL6 PFKM RBBP8 SCD CPT1A ATF4 LDLR HEL-S-133P HEL-S-281 FASN CD36 PMC6070710__F8 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response UBC POLE MCM10 GMNN ORC3 PMC11495891__F9 Application of EVs in the digestive system CAST PMC9218731__F1 Cardiomyocyte death in sepsis: Mechanisms and regulation NLRP3 RIPK1 GPX4 TLR4 RIPK3 MCU PANX1 SIRT1 MLKL GSDMD PMC11495891__F6 Application of EVs in circulatory system injury SIRPA CD47 MSC CAD PMC7654574__F8 Protein–protein interaction networks of energy metabolism canonical pathways affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells GPX4 HEL-S-30 ENO1 DLD AFM PFKL ACHE HEL60 ACAT2 HEL-S-162eP HEL-S-49 KYNU TXN2 PKLR ACO2 ACSL1 FURIN SDHD EHHADH CYCS PMC6883319__F6 MetaCore-generated pathway showing differentially expressed genes involved in mammalian target of rapamycin complex 1 (mTORC1) regulation EGF PTMS CS MAP2 AGTR1 EGFR MAPK7 GSK3B TBC1D7 MAP3K7 TRAF6 RAC1 MTOR DEPTOR PDPK1 TTI1 TLR4 PLD2 GHR PMC7654574__F9 Protein–protein interaction networks of the sirtuin canonical pathway affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells SIRT2 NAMPT NDUFV2 XPC TIMM23 NDUFS3 MTOR SIRT3 SIRT7 TIMM13 NFKB1 APEX1 NDUFB7 RELA NDUFB3 CYC1 APP TIMM10 ADAM10 GABPA ABCA1 SIRT1 SDHB BAX PMC6883319__F7 MetaCore-generated pathway showing differentially expressed genes involved in ATP metabolism PDE1C PDE4D FHIT PAPSS2 AK2 PDE10A PDE4B AK3 ENPP2 BST1 AK5 COASY PAPSS1 ENPP3 PDE7B PMC6883319__F8 MetaCore-generated pathway differentially expressed genes involved in antigen presentation by major histocompatibility complex (MHC) class I: cross-presentation CLEC12A OLR1 RAB33A RAB38 TLR9 RAB27A MSR1 IRAK4 MYD88 CD74 CLEC9A TLR7 TLR4 CD209 RAB32 RAB35 RAB11A EHD1 RAB4A HYOU1 TLR3 RAB10 SEC22B CD40 VCP ARF6 VAMP8 RAB3C PMC6883319__F9 Pathway analysis by Ingenuity Pathway Analysis (IPA) PNPLA3 GGH CASP6 ACOT8 NEU1 TGIF2 SLC35D1 RNPEPL1 PDE3A ADAT1 KIF3B MYC PLAGL2 TNNC2 PFDN4 TRIM25 IL15 POFUT1 STAU1 HNF4A ARFGEF2 HOXB13 CP CD24 PMC5308639__F7 Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression MDM2 SP1 STAT3 PMC9141422__F1 Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients UGCG B4GALT5 UGT8 B3GALT4 ST3GAL5 PMC3376735__F2 Regulation of the TGFB–BMP receptor complexes by reversible ubiquitylation USP15 WWP1 SMURF1 PMC4010202__F2 Proposed signaling mechanisms underlying the protective effects of mood stabilizing drugs against experimental stroke CXCR4 MSC SP1 BDNF PMC7895883__F1 Negative (blue) or positive (pink) regulation of TET2 in the inflammatory immune responses and related diseases CXXC5 PDC SOCS3 IRF7 LPL POLL ARG1 TET2 POLI FOXP3 PMC4999498__F2 Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells DOK3 BAD PLCG2 PTEN MTOR CD74 MAGI3 RAP2A SP100 BTK BASH HDAC2 SIN3A CD19 APBB1IP AKAP12 APC CD44 ARHA CXCR4 LYN GRB2 SYK DOCK2 MEF2C CDC42 TERT PMC6070710__F9 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response ATM CD2 CCNB2 CCNB1 RB1 ATR MRE11A CYCS PMC2737513__F1 IMP Dehydrogenase: Structure, Mechanism and Inhibition ADSL GMPR PMC3058380__F5 Focal adhesions in osteoneogenesis FYN MOS GRB2 PMC5354443__F11 Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway CDC2 ATR PMC8377368__F1 Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity CD1D APC IL33 IL25 RORA GATA3 ICOS FOXP3 PMC4731262__F1 Wnt/Beta-catenin signaling in kidney injury and repair: a double-edged sword DAAM1 APC GSK3B LRP5 LRP6 RHO CDC42 PMC7762844__F1 mTOR signalling in the cell at a glance TSC2 TSC1 DEPTOR SGK1 RHEB PMC3376735__F1 Logic of TGFB signalling from the membrane to nucleus SMAD4 ATF3 SKI CEBPB PMC5859335__F6 Relationship between cell cycle and common up-regulated genes identified between cancers WEE2 CCNA2 E2F4 PLK1 SMAD2 GSK3B MYC SMAD4 RB1 TFDP1 CDKN2A CCNE1 MDM2 RAD21 ORC6 CDC25B CDC45 MCM3 YWHAQ MCM5 MCM6 MCM2 CDKN1A CDKN2B CDK2 TGFB1 PCNA SFN TTK CDKN2D CDKN2C CCNH DBF4 ORC3 PKMYT1 ORC2 CDK7 FZR1 MAD2L2 ATM CCND1 CDK4 CDC2 PRKDC RBL1 CDC14B SKP1 STAG1 CHEK1 HDAC1 PTTG2 CREBBP BUB1B SMC3 ORC1L SKP2 ESPL1 ANAPC10 PMC6337789__F2 Biological interaction networking of identified HCAECs phosphoproteins in KD PML CAP1 MYO1C UBR5 TPR RING1 AKT1S1 WTAP FZR1 NCK1 ELAVL1 PAPOLA NELFB PRP4K POLR2A MYBBP1A SRSF4 ERCC5 MAPK1 HEL114 PECAM1 CALD1 DDX3X HEL-S-102 EMD MCM2 CDKN1A COPS5 NUP98 PMC9270353__F2 Liquid–liquid phase separation in tumor biology ATM RAD50 MRE11A FUS PMC8899988__F12 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway KIF18A SP1 PMC1877048__F1 Nutritional Route Affects ERK Phosphorylation and Cytokine Production in Hepatic Mononuclear Cells CD14 TLR4 PMC9497187__F9 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells GLB1 SMPD2 ASAH2 SMPD4 ACER1 CERS3 ACER3 LASS1 SPHK1 DEGS1 CERK DEGS2 CERS2 CERS6 PMC5800973__F4 KEY ROLE OF EXTRACELLULAR VESICLES IN THE METASTATIC PROCESS CXCR4 MMP9 CD44 CD81 PMC1783068__F1 Proximal B-cell receptor-mediated signalling pathways BTK FYN BASH BIK LYN GRB2 SYK BLK PMC8895352__F2 Androgen receptor (AR) signalling pathway associated PC IncRNAs (Adapted from Aird et al. ) CTBP1 IL6 STAT3 PMC8234323__F3 Asparagine: A Metabolite to Be Targeted in Cancers SLC7A5 ATF4 LCK ASNS MYC EIF4E ARF1 PMC9497187__F1 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells GLB1 SMPD2 SPHK2 SMPD4 UGCG CERS3 LASS1 SMPD1 CERS5 SPHK1 DEGS1 CERK DEGS2 KDSR CERS2 CERS6 PMC6263005__F1 Neuroprotective modulation of the unfolded protein response in Marinesco-Sjögren syndrome: PERK signaling inhibition and beyond ATF4 EIF2A XBP1 PMC10937592__F4 SCFAs bind with FFAR2, FFAR3 and GPR109A to improve hepatic steatosis, respectively FFAR3 FFAR2 PMC10937592__F5 Possible mechanisms of SCFAs-induced epigenetic modifications to improve NAFLD YY1 MBD2 MTOR PMC2633716__F1 Genetic Variation in Calcium Sensing Receptor (CASR) and Risk of Colon Cancer CASR NR1i1 CYP24A1 PMC8348617__F2 Senescence-Associated Glycine max (Gm)NAC Genes: Integration of Natural and Stress-Induced Leaf Senescence MAX SAG NRP1 NRP2 PMC7726811__F1 PIDDosome pathway regulates HCC initiation and expansion PIDD1 CASP2 PMC10937592__F3 Mechanism of SCFAs madiate a decrease in cholesterol levels ABCG5 NPC1L1 ABCA1 CYP7A1 PMC11210699__F2 Therapeutic effects of baicalin and baicalein ULK1 CCNA2 TLR4 CDK2 MTOR BAX PMC7064791__F1 CXCR3 receptor subtypes and related ligands that eventually result in CXCR3-B anti-tumor mechanisms, and responses in favor of tumor progression in the CXCR3-A signaling pathway following ligation of these ligands CXCL10 CXCL9 SRC PMC4206998__F2 MicroRNA induced by FSH at spermiogenesis IGF1R IGF1 VEGFA CCND1 FSHR PTEN CCND2 PMC11210699__F3 Therapeutic effects of baicalin and baicalein NLRP3 BNIP3 BDNF SIRT1 GSDMD PMC5811474__F6 Pictorial representation of p53 pathway regulated by E3 ligases and DUBs USP4 HIPK2 RNF43 USP2 SP2 USP24 USP11 TRIM25 TRIM13 ATM MDM2 RFWD3 TRIM28 USP42 PHF20 ZBTB33 UBE4B TOPORS CHFR BAX PMC8112354__F1 O-GlcNAcylation in Immune Cell Activation OGA TRAF6 PMC5811474__F4 Illustration of E3 ligases and DUBs that regulate extrinsic pathway of Apoptosis TRADD PAK4 TRAF2 FADD SH3RF2 ITCH PMC5811474__F5 Illustration of E3 ligases and DUBs that regulate TNF induced NFKB pathway USP19 USP21 TRADD TRAF6 ING4 PDLIM2 TRAF5 CYLD SHARPIN TRIM27 TRAF2 OTULIN FADD PMC4467418__F7 miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells AFP PTEN PMC8953107__F5 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells BAD CAD OTP LAT PMC7084447__F3 An illustration demonstrating BER FEN1 NEIL2 POLE SSB PARP1 LIG1 OGG1 PNKP PCNA NEIL1 TDP1 PMC8953107__F6 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells PI3 PTEN PMC5811474__F3 Regulation of Intrinsic pathway by E3 ligases and DUBs RNF7 BAD MEI1 TRIM32 TRIM2 UBR5 APC TRIM39 BAX PMC2928709__F4 Observation of the differentially expressed genes on the human cell cycle (A) and transforming growth factor beta (TGFB) signaling pathways (B) modified from Kyoto Encyclopedia of Genes and Genomes (KEGG) (www.genome.jp/kegg/kegg1.html) ACVRL1 NODAL MYC CCNH SMAD4 RB1 TFDP1 CDK7 CCNE1 CHEK2 FST NOG DCN AMH ACVR2B ACVR2A WEE1 MDM2 THBS1 SP1 PRKDC YWHAG PTTG1 RBL1 TFDP3 ACVR1 PITX2 SKP1 ARHA TNF THBS4 RBX1 CHEK1 EP300 THBS2 THBS3 CDK2 PPP2CA PCNA SKP2 ELL PMC2902905__F1 Sub-Cellular and Signaling Mechanisms Underlying Polar PIN Localization.A model of regulators and pathways contributing to polar PIN localization in roots is proposed based on results discussed in this review PIN1 VPS29 SNX1 PMC9497674__F9 Gene Expression Profiles of Human Mesenchymal Stromal Cells Derived from Wharton’s Jelly and Amniotic Membrane before and after Osteo-Induction Using NanoString Platform CTBP2 NUMB CCNA2 CTBP1 LFNG DLL3 NOTCH3 ADAM17 HES1 DLL4 MAML2 HDAC2 NCOR2 NOTCH2 MAML1 KAT2B RBPJ CIRSR FOSL1 PSEN2 DTX3 DTX4 HDAC1 EP300 PSEN1 PSENEN PMC11545099__F1 B cell receptor signaling pathway BTK BCR LYN SYK PLCG2 MTOR CD79B CD79A CD19 PMC5523853__F1 Key components of the stress response signaling network in C EGF IGF1R HSBP1 SMAD2 EGFR PTEN HIF1A MTOR PDPK1 RHEB RICTOR GRB2 STK11 SKI JUN SIRT1 SGK1 PMC10590753__F11 Differentially expressed proteins and metabolites KEGG annotation and visual analysis in the purine metabolism pathway OMP ADA APP PMC8234323__F1 Asparagine: A Metabolite to Be Targeted in Cancers ZBTB1 ATF4 ASNS EIF2A PMC8429149__F1 IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore TH IL36A IL36B TRAF6 MYD88 MAP3K7IP1 PMC8436187__F3 Release and activity of SQSTM1 in mouse sepsis TLR4 MITA SQSTM1 MYD88 GSDMD INSR PMC9362849__F5 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation RIPK1 TRADD CYLD IMPACT TNF TRAF2 MIB2 ITCH PMC4100108__F4 The possible regulatory pathway of melanogesis activation ASIP MC1R DKK1 PMC3828628__F1 IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK SOCS3 IRS1 STAT3 PMC6722462__F5 Metabolite pathway analysis with Pearson correlation coefficient only edges corresponding to correlations whose similarity was less than 0.5 are shown TNF ACD PMC4434617__F1 Role of transmethylation reactions in alcoholic liver disease HEL-S-61p VIT PMC9362849__F1 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation TRADD ATM CYLD SHARPIN H2AX OTULIN PMC12185963__F10 TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway TRAF6 TLR3 TAB3 PMC8181875__F4 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer HEL-S-102 HMGB1 PC SIRT4 MAML3 EGFR HEL-S-303 SMO UHRF1 TFAM SIRT1 PMC7680400__F4 Synaptic microRNAs in Alzheimer’s disease VAMP2 PTPN1 STX1A SNAP25 NRN1 SYT1 SIRT1 NRP2 EPHB2 PMC7997823__F1 Signaling pathways of the main cytokines involved in cardiovascular diseases TRADD SHE IL1R1 TRAF2 IL1B PMC8181875__F1 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer IL16 CXCL2 STAT3 PMC8181875__F2 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer RER1 PC RAD51 CA9 STAT3 PMC8181875__F3 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer HOXA9 DKK3 WNT7A TP63 TXNIP PTEN CDH2 PMC6748125__F6 Erythropoietin (Epo) binds to the Epo receptor (EpoR) to activate erythroid-specific gene transcription (EpoR, globins, glycophorin A (GPA), and miR-144/451) by GATA-1, resulting in hemoglobin (Hb) production EPOR ULK1 EPO ATG12 SPHK1 MTOR DKFZp686F0183 PMC8998143__F2 Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review ASIP PMC4677255__F2 Detected regulatory influences on the canonical Wnt pathway TLE3 LRRK2 DAAM2 TNIK APC NOTUM LRP5 LRP6 TCF19 TRIB2 EDIL3 DKK2 SMURF1 NKD1 FRZB LEF1 LRP4 NARF AXIN2 TCF7L1 TRAF4 APOE PMC5364150__F7 Shigella modulates the innate immune response in epithelial cells MDM2 TRAF6 TRAF2 PMC3686324__F1 Osteoporosis – a current view of pharmacological prevention and treatment LRP5 LRP6 PTH PMC10861537__F7 Summary: impact of chemotherapy on CAF-S1 and CD8 T cell density in HGSOC YAP1 FAP PRF1 ANTXR1 PMC3686324__F3 Osteoporosis – a current view of pharmacological prevention and treatment LRP5 LRP6 PMC7570440__F1 Major longevity pathways and longevity-associated transcription factors in C TFEB SKP1 MTOR SIRT1 PMC6905468__F8 Schematic summarizing the effect of ATR kinase inhibition in cisplatin-treated quiescent cells ATRIP ATR PCNA PMC5772637__F6 Pathway studio analysis of genes analyzed in the study by the gene array analysis and qPCR ANXA1 IKBKG ACTG2 ANGPTL4 FOS MMP9 PFKFB4 TMED10 COXFA4L3 DDIT4 CASP3 NFKBIA NFKB1 ANXA2 RELA CYC1 CASP9 BCL2 CAV2 BNIP3 ADM CASP8 NFKBIE BAX PMC5772637__F7 Pathway studio analysis of proteins whose genes were analysed in the study by the gene array analysis and qPCR MARCKS IKBKG ACTG2 FOS MMP9 PFKFB4 PARP1 TMED10 HMOX1 COXFA4L3 DDIT4 TMED1 CASP3 NFKBIA TIMP1 RELA CASP9 BCL2 ADM CASP8 NFKBIE PMC5564816__F6 Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGFB1-SMAD3-ID1 signaling pathway CDH2 ID1 RNF125 PMC6044452__F8 Possible signaling mechanism for cigarette smoke and FGF23-mediated regulation of FGFR4/PLCG/calcineurin/NFAT pathway FGF23 FGFR4 IL1B PMC6877688__F3 KEGG pathway enrichment analysis of photosynthesis related genes in S6, S72, and R (control) groups PES1 PC BOLL PMC7913870__F1 Hippo pathway STK4 LATS1 LATS2 PMC7484659__F3 Schematic model illustrates the neuroprotective effects of THSG on STS-induced toxicity by restoring BNDF-TrkB/Akt signaling axis and inhibiting apoptosis STS BDNF PMC4074185__F3 Hereditary leiomyomatosis and renal cell carcinoma KEAP1 HEL-S-133P PMC7913870__F3 Therapeutic targets to reactivate the Hippo pathway FRY IKBKE ALK STK4 LATS1 EZH2 LATS2 ELL PMC6877688__F4 The endocytosis pathway CHMP6 VPS25 LDLR AMPH ARF6 CAPZB PMC7573881__F5 Network of lncRNAs involved in regulating the Th cell activation pathway in tongue squamous cell carcinoma CXCR3 CCR5 RUNX3 SOCS3 STAT4 GRB2 CD8A SOCS1 GATA3 IFNG STAT3 PMC12120866__F6 Critical gene network analysis of the up-regulated DEGs in the M CXCL1 UQCRB COX5A SERPINC1 HEL-S-78p GC NDUFB6 NDUFB5 CENPA FGA HRG PLG LIF CXCL2 CCL4 APOB LTA NDUFB4 NDUFB1 UQCRH CXCR4 H3C15 H3C8 CCL20 AHSG NDUFC1 ZWINT H2AC21 APOH CCL3 PMC3398046__F5 MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets ADIPOR1 TP53BP2 RNF11 TFPI TNFAIP6 RIOK3 SAMSN1 RTP4 LCP2 MYO6 KRT4 ZFAND5 B4GALT1 TAB3 PMC5290526__F7 A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs CDH2 PMC9293663__F7 Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling MMP3 CXCL10 IL1B PMC3062664__F1 Metabolic insulin signaling pathway genes genotyped in the discovery cohort FYN PTEN FRAT1 IRS1 CBL PMC2790217__F17 Akt regulates growth by phosphorylating and inhibiting the TSC1-TSC2 complex in drosophila TSC2 TSC1 PTEN MTOR PMC5206652__F1 Identification of genetic susceptibility loci for intestinal Behçet’s disease SORT1 ERAP1 NENF FOS APP RNASE11 TBCC CHAC2 POMZP3 NAALADL2 PMC5720977__F1 Wnt and Hippo signaling network that either promotes or inhibits Wnt signaling through cytoplasmic and nuclear interactions of the two pathways BTRC YAP1 APC VGLL4 GSK3B TBX5 LATS1 LATS2 PMC2349985__F1 Role of Leukotriene B4 Receptors in Rheumatoid Arthritis LTA LTB IL1B PMC3226036__F5 A schematic representation of the two classical apoptotic pathways in mammalian cells DIABLO FADD PMC8778800__F1 FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target? IL1A FRS2 GRB2 PIK3CA MTOR PMC9605952__F1 Regulating pathways of ferroptosis KAT5 RBMS1 GPX4 SOX2 STEAP3 KEAP1 SLC7A11 ALOX15 LCN2 ASAH2 SRC FZD7 KLF2 SLC3A2 DAZAP1 BAP1 PMC9605952__F2 Ubiquitination on ferroptosis MIB1 KEAP1 SLC7A11 CD44 ABCC5 USP11 PMC9605952__F3 Autophagy on ferroptosis GPX4 COPZ1 HIF1A DKFZp686F0183 PMC10254355__F4 CIN and MSI signaling pathways in colorectal epithelial cancer: A modified cartoon from KEGG depicts known activated pathways in colorectal epithelial cells TBK1 CHUK BAD RIOK1 POLK SMAD2 TGFBR1 EGFR APC SMAD4 MTOR CCND1 BAX PMC6894087__F7 Schematic drawing that illustrates the signaling pathway involving mTORC1/rpS6/Akt1/2 and Cdc42 utilized by NC1 peptide to induce Sertoli cell BTB remodeling in the testis RPS6 CDC42 PMC4095764__F1 Physiological anticoagulant characteristics of blood vessels on endothelial cells PC TFPI APC TF PMC9402792__F5 MRNA–miRNA–lncRNA Regulatory Network and Factors Associated with Prognosis Prediction of Hepatocellular Carcinoma HEL70 MARCKS DUSP10 HEL-S-30 RECK JMY EGFR ISCU NR1C1 RHOB NOB1 PMC8431530__F3 Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis HEL-S-61p MTR DHFR PMC2553572__F2 DSB repair pathways ATM BRCA2 RAD52 RAD51 ERCC1 PNKP TDP1 PMC6151343__F10 A schematic pathway for rosiglitazone induced HO‐1 expression in HPAEpiCs TLR4 PAICS PMC12245916__F2 Signaling pathways for intestinal microbiota regulating the polarization and activation of intestinal macrophages IRF3 IL6 MYD88 PMC7403206__F3 Podocyte insulin signaling RS1 VAMP2 GRB2 INSR PMC6381368__F6 Schematic representation of the suggested pathway by which CAFs induce cell proliferation, EMT and metastasis in CRC cell CCND1 MTOR PMC8315016__F8 Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer NLRP3 IL1B GSDMD PMC9144739__F2 Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria BCR NPS CD40 IFNG PMC6350761__F1 Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00463c TPMT PMC6738830__F6 Proposed model for impaired apoptotic response to hMPV infection in NECs from asthmatics ATF4 EIF2A BAX PMC7445530__F1 Regulatory mechanisms of BLACAT1 on proliferation, invasion, metastasis, tumor cell cycle control, apoptosis, autophagy, and chemoresistance in multiple human cancers CCR2 VASP MMP2 MMP9 EZH2 CDH2 ABCB1 SUZ12 BLACAT1 STAT3 PMC7457047__F1 Drugs and antibodies that affect the function of the neuromuscular junction MUSK COLQ LRP4 ACHE PMC8526348__F2 Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction HEL-S-62p NLRP3 IL18 TLR4 VCAM1 CFH VWF SRC RHO TF PMC8155534__F6 Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling SMAD2 IL11RA PMC5013148__F9 Positive feedback regulation of type I IFN response mediated by IFNd-induced IRF3 and IRF7 activation in large yellow croaker STAT1 STAT2 IRF7 IRF3 PMC3953130__F2 Ack1 signaling pathway in normal and cancerous cells TMPRSS2 HK2 WWOX PMC11896877__F2 Activation process of nuclear factor kappa B (NFKB) and the regulation of the NFKB signaling pathway by the small ubiquitin-like modifier (SUMO) ANXA1 SENP6 SENP1 SENP2 PMC7555335__F3 Constitutive activation of STAT5 EPOR EGF PIM1 EGFR FLT3 MTOR TGFA PMC8634263__F9 Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/Beta-Catenin RUNX2 APC WNT1 WNT10A AXIN2 PMC8164819__F5 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance APC LRP5 STRAP DKK1 HDAC1 SUZ12 HES1 PMC8164819__F6 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance NODAL FRS2 FOS SMAD2 TGFBR1 SMAD4 SMAD1 DKFZp781O1323 PMC7059188__F2 Soluble factor-activated signaling pathways in fibroblastic cells in CNT-exposed mouse lungs TIMP1 CD63 SMAD2 SMAD4 PMC8202686__F3 A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis RHO RAC1 PMC4643662__F3 The role of S100 proteins and their receptor RAGE in pancreatic cancer S100A2 SHH S100A4 S100A6 PMC7851123__F1 Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer PALB2 FANCD2 ATM BLM RAD51 ERCC1 ATR PMS2 PMC5872691__F1 One-carbon metabolism and DNA methylation HEL-S-61p MTR DHFR PMC9332234__F1 Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease KEAP1 RBX1 PMC9634734__F1 BMP4 in adipose-derived stem cell differentiation: A minireview BAMBI BMPR2 BMP4 PMC2897904__F1 Proposed mechanisms of HDACi-induced apoptosis in colon cancer cells involving the mitochondrial pathway APAF1 HDAC10 HDAC7 HDAC5 BAX PMC7968000__F3 Tumor suppressive role of HNF4A SET CDKN1A RRM2 CCND1 BMP7 FUS ADAM17 TCF4 PMC4819564__F2 Signaling cascades of Cripto-1, Notch/CSL, and Wnt/Beta-catenin EGF NUMB NODAL CRIPTO SMAD2 APC SMAD4 SRC PORCN FURIN BCL9 PMC6330122__F3 Neurotoxicity of Anesthetics: Mechanisms and Meaning from Mouse Intervention Studies EGFR GSK3B MTOR INSR PMC7073187__F1 Main mechanisms by which the breakdown of tolerance to food antigens can occur IL13 IL33 IL31 IL4 IL5 IL25 TSLP PMC1797633__F1 Strategies of the different HCV proteins to antagonize IFN therapy STAT1 STAT2 EIF2A IRF3 IFNGR1 TLR3 PMC2724396__F1 Modified Lee-Heinrich model of wnt pathway APC GSK3B PMC6106831__F5 Granulocyte activation and diapedesis mediators show greater induction during diestrus phase infection than in estrus ICAM2 CXCR4 CCR4 IL8RB GLG1 JAM3 MIP ITGB1 PMC5637726__F1 The role of the TGF-Beta-Smad and BMP-Smad signaling pathways in myocardial infarction and the mechanisms of some associated potential therapies HMGB1 GIG8 SMAD2 SMAD6 SMAD4 GREM2 ABCC6 SMAD1 ID3 DKFZp781O1323 TRPV1 ACTR2 PMC5729346__F1 The abnormalities in the pathway of tyrosine metabolism in tyrosinemia type I HPD PAH PMC8151573__F1 Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors FAP SHH PTEN CCL2 TGFB1 STAT3 PMC6477778__F1 Proposed sources of NOD1 activation and corresponding physiologic, endocrine, and cell tissue communication events leading to insulin resistance in different tissues PC NOD1 RIPK2 PMC6168336__F6 In this illustration, potential mechanisms of tumor cell survival via crosstalk between components of the MET pathway, glycolysis, and autophagy are depicted HGF ATG3 MTOR AXL PMC8307280__F2 Harnessing Carcinoma Cell Plasticity Mediated by TGFB Signaling SMAD2 SMAD4 PMC3835370__F1 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes PALB2 BRCA2 BRIP1 UBE2T BRCA1 USP1 PMC7494613__F8 H3K27M mutations are dependent on a critical metabolic pathway also used by mIDH1 to regulate global H3K27me3 levels HEL-S-26 EZH2 KDM6B HK2 PMC9608452__F2 The microbiome and its metabolites in ankylosing spondylitis CXCL13 IL18 APC XBP1 PMC6971992__F2 ZIKV-induced ER stress initiates host cell unfolded protein response (UPR) EDEM1 ATF4 EIF2A ATF3 CHAC1 XBP1 PMC8097364__F2 Genome diversity and instability in human germ cells and preimplantation embryos BLM BRCA2 SSB SMC6 FANCM FANCL FANCA ATR BRCA1 FANCE PMC3835370__F5 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes RPS7 RPL35A RPS26 SBDS RPS29 RPS24 RPS10 RPL11 RPS17 RPS19 RPL26 NHP2 GAR1 NOP10 PMC9433691__SF1 Compressive force regulates GSK-3B in osteoclasts contributing to alveolar bone resorption during orthodontic tooth movement in vivo APC MMP9 PMC3920945__F3 Oncogenic and tumor suppressive autophagic pathways involved in miRNAs FOXO4 HDAC5 FOXO1 PMC4580556__F5 The debulking signature COL3A1 TNFAIP6 ACTA2 POSTN TGFBR2 SNAI2 BMI1 ASPN GREM1 MMP2 TIMP3 FAP FCGR2B CXCL14 CYP17A1 PRRX1 EGR1 CTSK SOS2 VCAN GATA4 GRB2 COMP SMAD1 COL10A1 TGFBI PMC3825743__F5 Quantitative Phosphoproteomic Profiling of Human Non-Small Cell Lung Cancer Tumors ATF7 ELK3 BAD CAMK2D RB1 RRAS2 MTOR MEF2D FYN EP300 GAB2 CDC2 SOS1 ATR PMC9420296__F2 Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells ATM TPP1 ATR TERT TERF2IP PMC9518657__F1 Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals ACE2 PMC8554658__F1 Molecular mechanisms of chemo‐ and radiotherapy resistance and the potential implications for cancer treatment EGFR CCND2 STAT3 PMC11671241__F7 Cortisol synthesis and secretion pathway and network of CRH‐ACTH‐cortisol signaling in Hu sheep MRAP LDLR MC2R PBX1 STAR PMC11671241__F5 Thyroid hormone synthesis pathway and network of TRH‐TSH‐TH signaling in Hu sheep TH TTF2 HEL111 TSHR ALB HEL-75 TPO TG PAX8 PMC11745090__F7 IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages EGFR JAK1 STAT3 PMC11671241__F6 Thermogenesis in Hu sheep FGF21 OMG COMP RHEB PMC4270061__F2 Cofilin pathway in breast cancer invasion and metastasis EGF EGFR RHO PMC6681775__F8 Regulatory mechanism of AQP1 in endometriosis WNT4 AQP1 WNT1 PMC8797698__F1 Immunotherapy and radiation for high-grade glioma: a narrative review IL10 TBK1 IDO1 AHR IRF7 IRF3 FOXP3 PMC6046295__F1 Mechanosignaling in normal keratinocytes and psoriasis TH CASR MTOR PMC4270061__F1 Cofilin pathway in breast cancer invasion and metastasis EGFR SRC RHO CDC42 PMC7215894__F1 KLF11-mediated modulation of the TGFB signaling pathway in normal cells and tumors TGFBR1 SMAD4 SIN3A PMC10377897__F3 KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review KLF4 NOTCH1 TF PMC2862867__F4 Sites of action of curcumin on cancer cells COX2 VCAM1 EGFR BCL2 ABCG2 PMC5452924__F1 Interaction of the E-cadherin-catenin complex APC SRC PMC5452924__F2 Operating mode of the E-cadherin-catenin complex in tumor metastasis EGF HGF APC WNT1 EGFR GSK3B IQGAP1 CCND1 PMC8436916__F9 DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis MMP3 COX2 MMP9 ACAN TRPA1 DNMT3B PMC7846853__F1 PI3K pathway in the context of BCR signaling along with various targets BTK BCR NFATC1 LYN SYK PTEN MYD88 CD79B CD79A CD19 STAT3 PMC9688888__F9 Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway HMGB1 CCND1 IL6 FADD STAT3 BAX PMC140098__F7 A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer FHL2 RHO PMC2581798__F3 Information flow through the JNK network FER PINK1 RET CDK2 FOS SMG1 CDK4 IPP JUN PMC3035679__F3 Human inherited and mouse experimental defects in the cholesterol biosynthesis pathway that cause myelin disorders CYP27A1 DHCR7 ABCA1 PMC3035679__F4 Human inherited and mouse experimental defects in the glycosphingolipids synthesis pathway that cause myelin disorders UGCG FA2H SMPD1 PMC3378544__F4 Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells APOA4 ABCG8 LPL HMGCR CYP7A1 CD36 PMC7827610__F1 Haem biosynthetic pathway and associated porphyria disorders AIP HMBS PMC5683102__F3 Loss of NLRX1 exacerbates neural tissue damage and NFKB Signaling following brain injury IL10 TRADD IRAK1 RELB TRAF6 IRAK4 CCL2 MYD88 TNF IFNG STAT1 NOD1 BCL10 BIRC3 CD40 CARD10 REL TRAF2 IRF-1 CASP8 FADD PMC6947352__F11 Cell cycle pathway CDK2 SMC3 SMAD4 DBF4 ORC3 CDK7 PCNA SKP2 PMC8645889__F7 Hif-1A/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker (Larimichthys crocea) under environmental hypoxia HSF1 BAX PMC5135597__F1 Intracellular cholesterol landscape: dynamic integrator of the immune response CH25H VAPA IFITM3 LDLR OSBP PMC6034647__F1 From mice to men: TRPC3 in cerebellar ataxia ATXN1 TRPC3 CACNA1A PDYN PMC6025249__F7 Schematic diagram showing the mechanism of action of TFs against LPS-induced acute liver injury HMGB1 GCLM KEAP1 GCLC IL1B FASN PMC10898204__F5 KLF participates in the pyroptosis process of ulcerative enteritis through positive regulation of TXNIP/NLRP3 pathway NLRP3 KLF4 TXNIP GSDMD PMC5437570__F3 Interaction of antagonists with Wnt5A/Ryk signalling in vascular endothelial cells HEL-S-15 PMC5373476__F7 Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis SOCS3 IL6 PMC6057448__F7 Death receptor signaling TBK1 LIMK1 TRADD ROCK1 LMNA DIABLO HTRA2 GAS2 DFFB DFFA SPTAN1 TRAF2 FADD ARHGDIB PMC7834962__F1 IFN-related signaling pathways modulated by OncoTherad, zinc, vitamin D and glutamine during viral infections IRF3 MYD88 PMC7754001__F7 Schematic diagram for the signalling pathways related to the EMT and airway remodelling in response to TGF‐B1 SMAD2 SMAD4 DEK PMC4527592__F7 Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation MICB ENO1 HEL-S-87p HIF1A PFKP HK2 HEL-S-68p HEL-S-162eP PMC9166417__F1 PIKfyve as a drug target PI3 FIG4 PIP4P1 PIKFYVE PTEN PMC6274779__F5 DEGs involved in glycerolipid metabolism and fatty acid degradation pathway DGKE CPT2 ACOX1 HEL-S-5 PMC11788431__F8 C1GALT1-mediated regulation of Hh signaling and EWSR1::FLI1 expression SUFU SMO EWSR1 PMC4991353__F2 Canonical and non-canonical Wnt pathways have differing effects in cancer APC LRP5 LRP6 ROR2 ARF6 PMC9647469__F3 Didang Tang inhibits intracerebral hemorrhage-induced neuronal injury via ASK1/MKK7/JNK signaling pathway, network pharmacology-based analyses combined with experimental validation PGR GPT PTGS2 MMP9 NR3C1 MYC NR1C1 IKBKB CASP3 KDR SLC2A4 CCNB1 SRC GRIN2B CASP9 NOS2 CSF2 PPARG JUN CASP8 IL1B PMC3810304__F1 Potential pathways by which CKD modulates the accumulation of arterial macrophages VCAM1 CCR7 CCL2 PMC8675148__F2 Exploiting natural antiviral immunity for the control of pandemics: Lessons from Covid-19 TBK1 CCR2 CCL7 IRF3 IFNAR2 IL6 CCL2 MYD88 IFNAR1 PDC TYK2 IL1B MAVS PMC2808140__F2 Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host MAPK7 TRAF6 PMC6859545__F2 Cysteine residues are critical mediators of the antioxidant and heat shock responses KEAP1 NFE2L2 HSF1 PMC5884251__F1 Oncogene and tumor suppressor gene products regulate glucose and glutamine metabolism in cancer TIGAR SCO2 GLS2 ENO1 PTEN HEL-S-68p HEL-S-162eP PINK1 GOT2 SIRT6 NEK2 HEL-S-133P HK2 GLUD1 PMC9523668__F2 Targeting non-coding RNA H19: A potential therapeutic approach in pulmonary diseases ROCK2 HMGB1 RUNX2 FTH1 ARHA PTEN SIX1 COL1A1 FGF9 NF1 NLRP3 TLR4 EZH2 TGFB1 STAT3 PMC8945958__F1 Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives LPCAT3 FACL4 KEAP1 SLC7A11 DHFR SLC3A2 SP1 HMOX1 PMC1410804__F7 Cdc42 regulates HF differentiation and cell–cell contacts in keratinocytes by modulating the turnover of Beta-catenin and plakoglobin APC CDC42 PMC3934763__F7 Insulin signaling KEGG pathway in adipose tissue TSC2 BAD TSC1 PDK2 GSK3B GRB2 INS MTOR RHEB INSR CBL PMC3934763__F8 PI3K-AKT signaling KEGG pathway in adipose tissue BAD CD37 PTEN RAC1 MTOR IRS1 RHEB TSC2 PI3 BCR APIP MDM2 RBL2 CD19 PMC12206661__F7 PI3K-AKT and Hippo pathways play important roles in the regulation of ovarian tumor cell proliferation and PD-L1 expression LAT2 LATS1 PTEN LATS2 LAT PMC4333457__F6 Proposed human innate immune signaling pathways activated during V MPO STAT2 IRF9 OLFM4 LCN2 TRAF6 S100A9 MYD88 IL12B STAT1 NLRP3 TLR4 S100A8 IL17A EPPK1 TYK2 DEFA1B JAK1 NOS2 OSM STAT3 CASP4 PMC9062100__F2 Toll-Like Receptors and Th Responses in Viral Myocarditis TLR5 IL18 TLR7 TLR4 IRF7 MYD88 TLR1 TLR10 IL1B TLR3 STAT3 MAL PMC8612763__F6 Metabolic changes associated with replicative lifespan (RLS) ENO1 GPD1 PMC9062100__F4 Toll-Like Receptors and Th Responses in Viral Myocarditis TH TLR4 TRAF6 TLR3 PMC3945033__F2 Computational simulation of eicosanoid profile in ATP-stimulated BMDM HPGD LTA CTRL PTGS2 ALOX15 PTGES ALOX5 PTGS1 PMC8016325__F6 Moringa isothiocyanate-1 regulates Nrf2 and NFKB pathway in response to LPS-driven sepsis and inflammation MAF KEAP1 IL6 PMC3679475__F1 Inflammatory adipokines suppress insulin signaling resulting in insulin resistance PTEN MTOR FOXO1 PMC5009362__F9 Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TAB3 PMC5592202__F5 Schematic drawing of the efferent signaling pathway of the inflammatory reflex in the context of the cholinergic system in immune cells CDA ChAT HEL-S-11 ICAM2 SLURP1 MYD88 CA4 PMC11482718__F10 Graphic summary of potential signaling pathway involved in MG-induced lipotoxicity in vitro and in vivo GLO1 TG HMGCR FASN PMC10665998__F6 Long non‑coding RNA PEG13 regulates endothelial cell senescence through the microRNA‑195/IRS1 axis VCAM1 MDM2 IRS1 PMC8242058__F6 Endoplasmic reticulum stress, chondrocyte apoptosis and oxidative stress in cartilage of broilers affected by spontaneous femoral head necrosis CASP3 KEAP1 ATF4 EIF2A CASP9 BCL2 ERO1A XBP1 CASP8 DKFZp686F0183 PMC6441080__F7 The regulation of CP biosynthesis and the attachment to PG in S HEL-S-66 CP PMC8960436__F3 Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments PIK3R1 CHIT1 EGFR TGFBR1 MYC BCL2L1 WAS HEL-S-7 HMOX1 INSR STAT1 MMP3 ITK BTK FLT1 FGFR1 F2 PTPN11 SRC CCND1 IL2 MAPK1 ELANE SERPINA1 NR1H3 NR1H4 BAX PTGS2 MMP9 NR3C1 VEGFA HRAS NR1C1 CASP3 HEL111 TIMP1 IGF1 CYP2C9 LCK GRB2 SYK RAF1 PPARG TGFB1 ACADM PMC8835572__F2 Cancer as a Metabolic Disorder MYC PTEN HEL-S-133P HK2 PMC8829012__F3 HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease HLA-G ZAP70 KIR2DL4 IL6R STAT3 PMC8835572__F4 Cancer as a Metabolic Disorder LDLR ACSS2 ACLY MTOR CD36 PMC6261125__F6 Transcriptome-wide identification of genes involved in Ascorbate–Glutathione cycle (Halliwell–Asada pathway) and related pathway for elucidating its role in antioxidative potential in finger millet (Eleusine coracana (L.)) LTA SAG PMC10030587__F2 Key events in cancer: Dysregulation of SREBPs HEL-S-26 TNF MTOR FDXR PMC5248531__F2 Mechanisms by which alteration of normal miRNA profiles can occur, leading to aberrant miRNA profiles in childhood solid tumours DGCR8 DICER1 MYC DROSHA RAN XPO5 TARBP2 PMC8003896__F3 Hcy metabolic pathways PMC8456981__F1 ROCK2 controls the balance between pro-inflammatory and Treg cell subsets, regulates cytoskeletal dynamics and profibrotic gene expression and drives both chronic inflammation and fibrosis in cGVHD ROCK2 ARHA JAK3 LPA IRF4 STAT3 FOXP3 PMC2790850__F2 Aberrant Myc expression causes mammary cancer ERBB2 MYC USP28 BRCA1 PMC9309761__F4 Analysis of Competitive Endogenous RNA Regulatory Network of Exosomal Breast Cancer Based on exoRBase BAD PERP ATM CD82 MYC CYC1 ATR PMC4120759__F1 ER stress and UPR ATF4 ASNS EIF2A PMC8638098__F5 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model XCR1 IL3RA EPO RELT CCL21 CCL7 CCL5 TNFSF13 CCR8 IL17RC CCL1 CXCR6 CCR1 BMPR2 CLCF1 GHR BMP5 IL7R IL17C CCL25 IL9R TNLG5A CSF2RA TNFRSF10C BMP8B INHBC IFNW1 BMP3 CCL26 IL20RB CXCL10 LTB CCL4 IL25 TSLP THPO IL12RB1 TNLG8A CCL20 CCL22 TGFB1 IL17B XCL2 GHB2 IFNA1 NODAL CSF3 ACKR3 CSF3R TGFBR2 CSF2RB PPBP BMP4 CCR10 BMP8A LEPR IL2RB IL10 GDF6 IL13RA2 IL36B MSTN IFNB1 TNLG2B TNLG7C CNTF CXCR3 LTA CCL15 IL23A INHA CD40 CCL23 CSF1 IL18RAP OSM INHBE PMC6829385__F1 MAPK signaling pathway: ERK1/2, JNK1/2, and p38 EGF ATF2 TNF PMC8638098__F6 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model APLN F2RL3 F2RL1 GCK DRD2 PENK VIP GHR GABRA2 ADM CHRNG PTGIR FPRL2 SST RXFP4 UCN3 UCN2 PRLHR INSL3 FPR2 CHRNB4 ADRB2 CHRNB3 SSTR4 LTB4R GRIA2 CHRNA3 CHRNA2 GLRB CHRNA6 CCKBR LPAR4 GLRA2 GLRA3 GCGR EDN1 NPW LEP EDNRA CNR2 P2RY2 CHRNE GABBR2 TAC4 GRID2 CHRNA10 MC4R PRLH MC3R GPR156 GRIA4 GABRQ GHRHR P2RY10 HTR2A GPR50 HCRTR2 HTR2B P2RX5 P2RX4 P2RX3 HTR6 HEL-S-62p P2RX2 RLN2 RLN3 KPG_011 TAC3 CALCR CCKAR GCG DRD5 GZMA TACR3 TRHR NR1A2 SCT GIPR PMCH NR3C1 PTGER4 CGA SCTR NMBR SSTR5 GABRR3 ADORA2A CHRM4 GHRL CHRM3 PRLR TBXA2R ADRA2B PMC4595995__F3 HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling TREM1 SIGIRR TRAF1 ECSIT MYD88 TNF MAP3K7IP1 NOD2 PMC5953011__F1 Mechanisms regulating the canonical and non-canonical Wnt pathway TBL1X APC CHD8 SHANK3 DYRK1A PMC6477904__F1 Blnc1 assembles ribonucleoprotein transcriptional complexes with hnRNPU to form a positive regulatory loop with EBF2 and Zbtb7b CELF1 ZBTB7B EBF2 PMC7465322__F7 Possible functional network of the AR induction pathway in sugarcane BAK1 MYC PMC11734547__F6 Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) ITPR2 GNRHR EGFR GRB2 CDC42 PMC2857169__F5 NFKB in conventional T-cell activation APC IL5 PMC3382229__F4 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis HP CCL15 DEFA4 CXCL5 SFTPD NUTF2 PACSIN1 DEFA3 SLPI SYVN1 APOL1 PMC6790333__F5 Cell motility in cancer invasion and metastasis: insights from simple model organisms FOS SRC TNF PMC5640840__F8 Schematic diagram showing the observed changes induced by HCV in endoglin-associated cell signaling pathways SOX2 CCND1 BCL2 ID1 SMAD1 SOX4 HES1 PMC9031373__F3 Evolving View of Uremic Toxicity AHR EGFR PMC2575612__F4 Inter-individual mRNA expression variances in the mitogen-activated protein kinase (MAPK) signaling pathway in rheumatoid arthritis (RA) compared with normal control (NC) DAO MOK POR PMC3382229__F5 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis MMP7 DEFA6 DEFA4 DEFA5 DEFA1B DEFA3 PMC6111853__F2 Proposed working model for the role of Rho GTPases in S1P‐induced GEnC activation in the presence of MPO‐ANCA‐positive IgG S1PR2 S1PR1 ARHA S1PR3 S1PR5 RAC1 S1PR4 PMC2873439__F7 CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2 PI3 SRC CXCR5 PTEN DOCK2 PMC4557668__F8 JNK-dependent gene regulatory circuitry governs mesenchymal fate HNF4A CDX2 MEOX2 ETV6 NFIL3 TCF12 PCBP4 LMO7 NR1H4 PMC5863732__F3 Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, Metabolic and Disease Implications OTC ARG1 ASL SIRT3 PMC10586807__SF3_1. Correlation between CRISPR KO and CRISPRa screen gene hits within certain pathways BTRC ATG3 AJUBA ATG10 TNF MTOR STAT1 RIPK1 WNT3A TNFRSF1A AXIN1 CCND1 MAPK1 SOCS1 PMC6161805__F5 Smoke-induced microRNAs and their target genes BRAF MAP2 SMAD2 SMAD6 NR0B2 RPS15 LMNA TUSC2 XBP1 SLC38A1 BCL6 AGO2 DICER1 MAP2K1 IL17A IL17B PMC3665639__F2 Cell cycle regulation of Golgi membrane dynamics STX5A PMC5983164__F2 RAS effector pathways TSC2 BAD TSC1 PTEN IRS1 PMC4580101__F5 How the embryo makes a limb: determination, polarity and identity HOXD11 HOXA11 HOXA13 HOXD10 GLI3 FGF8 SHH HOXA10 HAND2 HOXD13 HOXD12 PMC3712075__F6 Schematic diagram showing the involvement of CPT1C and ceramides in the hypothalamic ghrelin signaling pathway BSX NPY CPT1A AgRP CPT1C PMC2254585__F5 In silico knockout of PLCG1 in the HGF stimulated signalling network ATF2 GRB2 SRC PTEN SOS1 STAT3 PMC3490020__F1 The main MicroRNA biosynthetic pathway AGO1 AGO2 DROSHA PMC8995768__F1 Bone Morphogenetic Proteins Shape Treg Cells BMPR2 ACVRL1 ACVR2B ACVR2A RUNX2 BMPR1A TGFBR1 SMAD6 ACVR1B TGFBR2 ID1 PMC8422078__F1 Synthesis of GDP‐L‐fucose by the de novo and salvage pathway POFUT1 FUOM GMDS SLC35C1 FPGT FUCA1 PMC3857018__F1 Potential mechanism for active DNA methylation involving TET-mediated oxidation of 5mC, followed by TDG initiated BER pathway via recognition of 5hmC and 5fC (AP is an abasic site) (adapted from ()) TDG TET3 TET2 TET1 PMC9246655__F4 Insights from two independent transcriptomic studies of the bovine corpus luteum during pregnancy PML MAP3K1 SMARCD3 RDH12 ZBTB16 PNPLA4 AKR1C4 ADCY5 MAP3K5 PTEN DHRS3 TRIM24 PMC8624719__F3 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC9327212__F1 Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma BAD PTEN RPS6 RHEB BAX PMC9239783__F6 Exploration of the Molecular Mechanism of Danzhi Xiaoyao Powder in Endometrial Cancer through Network Pharmacology HRAS PMC8624719__F1 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes TBK1 MFN1 MFN2 CGAS TLR7 IRF7 IRF3 MYD88 TLR3 MAVS PMC8624719__F2 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes MYD88 FADD PMC5487853__F2 Representation of cilia-associated molecules that have been implicated in DNA damage responses (DDR) PCM1 MDC1 ATM CDK2 CCNB1 CDC2 NEK8 CEP63 ATR H2AX CEP164 OFD1 INPP5E PMC4747493__F8 Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer EGF DUSP4 EGFR IL6 PMC4565031__F2 Case study 1 (synthetic signaling pathway): Hypergraph showing every possible logic gate consistent with the prior knowledge network EGF MAP3K1 EGFR MAP3K7 RAF1 TRAF2 PMC9043318__F2 miRNAs Can Affect Intestinal Epithelial Barrier in Inflammatory Bowel Disease TLR4 MYD88 IL1B PMC8192809__F2 Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis ABCA1 PMC4978554__F1 CTLA-4 pathway inhibition APC CD80 PMC3898176__F2 Toll pathway MYD88 TRAF2 FADD PMC10963904__F4 Metabolic map of the L‐methionine synthesis pathway of E CIT THRA MAL PMC6324668__F1 Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins SLFN11 ATR H2AX TDP1 PMC10963904__F2 Metabolic map of the l‐methionine synthesis pathway of E CIT GLA THRA MAL PMC7292789__F1 Vertebrate complement cascades and the particular steps Lyme borreliae anti-complement protein interact HEL-S-62p C9 FH C1S C4A PMC8199487__F7 NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the Beta-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition HDAC8 CCND1 BCL2 BMX BAX PMC10963904__F3 Metabolic map of the l‐methionine synthesis pathway of E TH CIT THRA MAL PMC230332__F7 Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB BMP2 SMAD2 BMP7 SMAD1 DKFZp781O1323 PMC3479242__F4 Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes HEL-S-62p PTS MPL PMC7786923__F8 Lnc-GAN1 repressed cell proliferation through cell cycle signaling pathway CCND1 CDK4 PTEN HEL-S-162eP PMC10742434__F1 Gut microbiota–host interplays in tryptophan and tyrosine metabolism, which affect mood and emotional states TH ASMT DBH PMC5524058__F8 Mechanisms of halofuginone action ATF4 EIF2A PMC3929326__F6 Regulation of Hippo-Yap1/Taz signaling by polarity complexes PATJ AMOT NF2 PALS1 CRB3 SCRIB LATS1 LATS2 PMC7182966__F3 Cancer hallmarks by the crosstalk between VEGF and Rho GTPase signaling pathways SRC ARHA RAC1 PIGP CDC42 PMC7926238__EV5 Models for disassembly of the metazoan replisome. The figure summarises data from this manuscript together with previous studies with early embryos of Caenorhabditis elegans and extracts of Xenopus laevis eggs MCM3 MCM5 MCM6 MCM2 TRAIP UFD1L OFD1 CDC45 PMC5684302__F2 Interrelationships between growth factor, nutrient availability and energy sensing pathways in metabolic regulation in health IGF1R IGF1 MTOR PMC5056494__F1 Signal transduction pathway mediated through CLEC-2 BTK SRC SYK LAT PMC5695117__F8 Proposed model for the autophagy process during E TSC2 ETF1 TSC1 TFEB PTEN ATG14 RHEB PMC4864533__F1 Signaling pathways downstream of Group I mGluR stimulation TSC2 TSC1 EIF4E RHEB PMC11928765__F2 Epithelial growth factor receptors (TGFBR/EGFR/KGFR) cellular signaling and their regulation by 16E5 EGF HGF SMAD2 FGF2 EGFR SMAD4 RHEB TSC2 TSC1 FRS2 SMURF2 FGF10 GRB2 TGFA ESRP2 ESRP1 STAT3 PMC5865411__F8 Proposed model for the novel dual functions of toll-like receptor (TLR)-10 in regulating IFN signaling IRF7 MYD88 SARM1 TLR10 TLR3 PMC3369892__F8 Summary diagram of the proposed adrenomedullin (ADM) signaling pathway in the retina RAMP3 ADM RAMP2 PMC3306173__F6 Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis TBK1 IRF7 IRF3 TLR3 PMC3419830__F1 Mechanisms of action for therapeutic agents in treating or preventing HAE HEL-S-62p PLG PMC5740757__F4 Interaction pathway of miR-1270 and target genes PARVG CREB3L2 TBL1X STAT2 MAML3 IRF8 PRKX CDC37 ULK2 FOSL2 CRK DVL3 PDPK1 INSR GABBR1 GAB2 KSR1 LYN STK4 SP1 SOS1 PREX1 ITCH CREB5 PMC6781492__F3 PPI networks and GO and KEGG pathway analyses for the top two positively co-expressed hub modules of SNHG7 in thyroid cancer RPS7 RPSA RPS29 RPS24 RPL31 RPL12 RPS19 SART1 LSM7 RPL23 SYF2 RNPS1 RPS20 SNRPC RPL7 RPL22 PPP2R1A EEF1G RPS5 U2AF1 RPS27A RPL26 RPL32 RPS14 FBL RPL36AL RPL36 RPL38 SNRPD3 RPL37 TXNL4A RPL4 RPS11 RPS8 RPS9 MRPS18A GTF2F1 PRPF6 RPS3A RPL8 MRTO4 RPP21 CD2BP2 SNRPE RPL29 RPS17 RPL28 SNRPB MRPL17 RRP7A CPSF1 MRPL27 LSM4 LSM2 TPT1 TBL3 RPL27A RPS21 RPS23 DDX49 SMG9 RPS4X RPL7A MRPL2 CTNNBL1 MRPS2 PABPN1 POLR2F RPL13 NACA POLR2H POLR2J RPL19 SF3A2 RPL23A EIF3G EIF3E PRPF31 FAU EIF3K EIF3D IMPDH2 RPL3 NOB1 PPIE PPIH RPL35 HEL-S-310 RPL18 RPL30 IMP3 RPS16 IMP4 RPL39 RPS13 XAB2 RPS3 RPLP2 RPL27 BUD31 SNRPA RPL11 RPS2 RPL10A RPS12 RPL34 RPS15A RPL13a RPL6 RPS25 EIF3F REL RPL10 PMC6781492__F4 Bioinformatics analyses for the top two negatively co-expressed hub modules of SNHG7 in thyroid cancer WAPAL GOLPH3 UBR1 UBE3C WWP1 HECTD1 RANBP2 TP53BP1 PI3 SMC1A UBA6 GOSR1 LTN1 RNF6 SPTBN1 CDC27 RAD50 REV3L RNF111 COG6 PRKDC COG5 DYNLL2 PJA2 KLHL20 KLHL9 KLHL5 GOLGB1 MAPRE1 PAFAH1B1 VHL UBE2H HUWE1 STAG1 NEDD4 RECQL TRIP12 PPP2R5C PIK3CA PPP2R5E ATR TRIM37 CLASP2 ITCH PMC4656203__F1 Folate transport and folate mediated 1-carbon metabolism in eukaryotic cells (for gene abbreviations and enzyme commission numbers, see and , respectively) GGH FOLR3 SHMT1 FTCD FPGS MTHFD2 RFC1 ABCC1 HEL-S-70p HEL-S-51e AMT MTHFS MTHFD1L PMC5548025__F7 A model of mTOR signaling pathways involved in AS CCR7 ABCA1 MTOR SIRT1 PMC5846794__F6 Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy PIK3R1 CHUK KIF23 MAPK8 EGFR MAPK3 SMAD2 MAPK14 SMAD4 DMD DAG1 TNFSF6 MAPK12 SRC YWHAG ACTN4 CAMK2D FOXO3A SNTA1 KCNJ12 ACTN2 ACTA1 PRPF40A PTPN13 IKBKB GAB2 NFKB1 LCK GRB2 PIK3CA ITPKA HEL-S-93 NCF1 SHC1 CAMK2A PMC8063416__F2 Still’ disease interactome a considering all disease effectors and their direct interactors and b focusing on disease effectors and their interaction to drug targets, and comparison to c pathway enrichment results of sJIA gene expression data SOCS3 CS TLR9 SQSTM1 CX3CL1 RAB27A CXCL8 MIP MYD88 C4A HMOX1 DKFZp686F0183 MMP3 TNFSF6 IL18 TLR7 C1QA IL17A IFNA2 IL4 IFNGR1 IL1B CXCL11 HMGB1 IL13 CXCL10 S100A12 IL18BP IL6 S100A9 NCAM1 SH2D1A UNC13D IL12B NCR1 NCR2 C1QB NFKB1 RELA IL23A S100A8 IL2RA IL-21 CSF1 PPARG INHBA IL18R1 PMC4940627__F6 Schematic diagram of the mechanism of THs regulating gallstone formation in vivoFXR/RXR heterodimers which mediate phosphatidylcholine and bile salt transporters (ABC-B4 and ABC-B11) are down-regulated by THs PC ABCB4 ABCG8 ABCG5 LDLR ABCB11 PMC7288469__F4 CFTR Proteostasis Interactors STX6 DNAJC5 RNF185 DNAJB1 SYVN1 CFTR HEL-S-102 SEC16A DERL1 RFFL DNAJB12 SYK SIN3A PMC5192315__F2 Toll-like receptor signaling pathways IL16 TLR4 IRAK1 RELA TRAF6 ECSIT MYD88 TK1 TIRAP PMC4183827__F9 Proposed DAT/PAT, sulfolipid, and phthiocerol dimycocerosate biosynthetic pathways CHP2 CHP1 MMP17 MPL PMC4351453__F8 A proposed model of our study is shown STC1 MTOR UCP2 PMC5327616__F9 BM-MSC modulates inflammation response through mTORC1-p70S6K/mTORC2-Akt Signal Pathway CASP3 RICTOR TLR4 MSC MTOR IL1B STAT3 MLST8 PMC4008360__F3 Ingenuity pathway network analysis of differentially expressed miRNAs MYZAP ENPP4 WDR35 CA13 CREB1 IL11 DRD2 PMC2708980__F8 Proposed signaling pathway RASGRP3 BCL2 BAX PMC12187936__F3 Anti- and pro-tumoral immunity regulated by tumor-resident bacteria MPO ARG1 CHI3L1 IFNG PMC6690202__F1 Main pathways of NFKB activation TRADD RELB CD40 REL TAB3 PMC5240041__F3 Intracellular signaling pathways in lymphangiogenesis VEGFC RAC1 MTOR PMC5589692__F6 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells MAPKAPK2 LIMK1 FYN VEGFA CDC42 PMC5589692__F7 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells SRC PMC11878248__F2 Predicted targets of host miRNA responsive to HSV-1 infection SOCS1 PMC3836475__F4 Gene network associated with IFN pathway signaling IFIT3 PARP14 IFIT2 CMPK2 GBP5 RTP4 USP25 MX2 USP18 MX1 STAT1 GBP1 SP110 OAS1 OAS2 OAS3 XCL1 LGALS3BP GBP2 UBA7 FAT10 IRF-1 MS4A1 STAT2 IRF7 IRGM IRF9 BST2 GBP7 ATF3 IFI27 ADAR IFI44 CDKN1A PARP12 RNF114 ISG20 NR4A3 EPSTI1 FBXO39 GPR141 ZNFX1 VCP IFIH1 PMC8073701__F5 Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer ATF7 PCK1 ATF2 EGFR TRAF3 ATF1 CREB1 CEBPB SOX9 POLR2A HEL-S-8a HDAC2 JUN NFYA HLF CREB3L3 CGA TLR1 CREBBP EP300 CREM NFIL3 CRTC2 KMT2B ZBTB21 BARX2 TSSK4 TF PMC4808796__F1 ATM, ATR and DNA-PK signalling pathways RNF168 RNF8 ATM TOPBP1 ATRIP MDC1 ATR MRE11A BRCA1 PMC3595301__F1 Canonical or Wnt/Beta-catenin–TCF/LEF signaling LEF1 APC GSK3B ARHA RYK ROR2 DKK1 CDC42 PMC3595301__F3 Crosstalk between Wnt and local inflammatory signaling pathways for the control of SVZ niche homeostasis WNT1 GSK3B PMC6643140__F7 Proposed mechanisms of TRIP13 functions in BCa EGFR ID1 TRIP13 PMC7296543__F1 Canonical signaling pathway of TLRs TBK1 CD14 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 LBP TIRAP PMC6909891__F1 Mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2 signaling pathway and function TSC2 ULK1 TSC1 IGF1 PMC102186__F9 Ras-mediated signaling pathways ATF2 NRAS ARHA RHO RAC1 PMC7498644__F2 Activation of the canonical NLRP3 inflammasome NLRP3 IL18 MYD88 IL1B PMC3663908__F1 Major signaling pathways leading to cellular apoptosis BAD HTRA2 FADD BAX PMC2952128__F4 Functional gene networks identified using IPA from differentially expressed genes between control and 300 nM reversine-treated annulus fibrosus cells TNLG2A KRT20 VPS33A DNAJB4 PAX7 BMI1 AHNAK HCTP4 HEL-S-14 TLL1 ORM2 ITGA6 CKAP2 HEL-S-66 CD55 BTG2 TTC14 PMC8161229__F3 Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis TH FANCA PMC5837202__F3 Effect of PCB126 exposure on the calcium signaling pathway PLN TNC BCR CAV3 MCU CAV2 PMC4458453__F1 Pathway of eukaryotic translation initiation ELF3 ELF1 SUI1 PMC9266809__F6 miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR YY1 MTOR PMC4489351__F1 EDA pathway and its downstream signaling EDARADD EDAR TRAF6 TNLG7C PMC9121316__F1 Forward single‐cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single‐cell solution TOX MTOR PMC9374747__F4 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states PGP IRS1 TF PMC6755815__F6 The pathway by which LPA increases LPP3 expression RELA RELB LPA PMC6682839__F3 Cell death and survival in the contrast of susceptible vs IFRD1 NRF1 NACC2 GINM1 PROX1 TPST1 FOSL2 TFDP1 WDFY3 HPGD ATXN1 NRP1 MSMO1 TRIO PMC6462535__F6 Ethanol regulation of stem cell differentiation via activation of RA signaling LRAT CRABP2 RBP4 RDH10 DHRS3 ALDH1A2 PMC10418437__F1 Signaling pathways activated by free mtDNA in the pathogenesis of metabolic syndrome TBK1 NLRP3 CGAS TLR9 IRF7 TRAF6 IRF3 MYD88 IL1B TAB3 PMC9374747__F6 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states RREB1 EGR1 HOMEZ RFX1 ETV4 HOXC6 NR1C1 SP100 PKNOX1 RELA ZBTB16 KLF4 PBX3 MYOG TF PMC3744328__F1 Sumoylation and regulation of cardiac gene expression XPC SAE1 HDAC1 PMC3408825__F1 Autophagy pathway: signaling systems and three proposed membrane sources in autophagosome formation NLRP3 HMGB1 AIM2 IL1B PMC6715590__F1 NLRP3 inflammasome activation pathway NLRP3 IL16 TLR4 IL1B PMC12034127__F3 Iron overload activates the AKT/mTORC1 signalling pathway and inhibits TFEB expression, thereby inhibiting autophagy-mediated degradation of misfolded Alpha-syn and leading to neuronal death TFEB IGF2 TF PMC9454487__F1 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics SMAD2 RYR1 NOX4 PMC6174659__F1 P53 transcriptional pathway EGF ATM MAP4 EGFR GML MDM2 BCL2 ATF3 TGFA PCNA BAX PMC9454487__F2 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics SMAD2 SMAD4 PMC2724047__F6 Activation of the Akt (insulin signaling pathway) and FXR by bile acids in hepatocytes EGFR SRC PMC8080632__F8 Schematic diagram illustrating the theory in the current study ARHA NEUROD2 PMC7080523__F4 Innate immune regulation of cGAS‐STING‐mediated immune pathways by the host or viral elements CGAS IRF7 IRF3 TYK2 CD80 MYD88 JAK1 HBZ IFI16 PMC2724047__F5 Major cell signaling pathways activated by bile acids in hepatocytes ERBB2 ERBB3 FGFR4 HRAS CDC42 PMC7861567__F5 Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates E2F4 FOXO4 MYC CCND1 TCF7L2 EZH2 ESRRA CCDC17 JUN RBL1 TCF4 ZNF333 PMC4836034__F1 Autophagy pathway and its interaction with HSV-1 TBK1 ULK1 KIAA0226 SQSTM1 EIF2A EIF2AK2 ULK2 UVRAG PMC8086039__F1 Kill Two Birds with One Stone: Role of the RIPK-3 in Necroptosis and Inflammasome Activation NLRP3 RIPK3 MCU MLKL PMC6112260__F9 Protein-protein interaction networks of DEGs involved in the staphylococcus aureus infection signaling pathway HEL-S-62p RPS4X TUBB8 RPL7A HEL2 TUBB6 FLNA CSNK2A1 RNF149 GIT2 MED23 HLA-DMA RPL31 EIF3CL RPL12 EMC6 TRFP RPS28 CFD DDX19B HLA-DRB3 SQLE PDE3B HEL70 RPS14 SET RPL36 PURA RPL35 RPS15 RPS16 RPS9 NAALADL2 RPL8 HLA-A RPS25 FNDC4 RPL5 OTULIN PMC9389037__F1 The macrophage-to-myofibroblast transition in renal fibrosis SMAD2 SMAD4 SRC JAK3 PMC9693478__F3 Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex ZNRF3 RSPO3 WNT4 MRAP MC2R SHH SMO EZH2 WNT2B AXIN2 FRZB PMC6828748__F4 Molecular pathway linked to oxidative stress response in E ADRM1 PSMD2 PMC1794588__F3 Small subnetwork identified for the shift from glucose to ethanol as carbon source PKIA AIDA MAL PMC3018162__F1 Schematic and mathematical representations of the main model assumptions SI CSA2 GAA PMC4026741__F1 Pattern recognition receptors in respiratory anti-viral immunity FOS SRC TRAF6 IRF3 TYK2 JAK1 JUN TLR3 PMC9585227__F1 Lipids for CD8+ TILs: Beneficial or harmful? CPT1A LDLR LAG3 TNF PPARG IFNG STAT3 CD36 PMC4197041__F1 Getting ready for building: signaling and autophagosome biogenesis ULK1 EGFR TRAF6 MYD88 RHEB TSC2 SLC7A5 TSC1 TLR4 GAB2 EIF2A GRB2 STAT3 PMC6939855__F1 Mechanisms of endocrine therapy resistance in ER+ breast cancer and treatment strategy NEIL2 NF1 PI3 DDR1 ATM CDK4 PMS2 PMS1 PMC9081983__F3 Non-Coding RNA in Neurological Complications Associated With Enterovirus 71 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 IRAK3 PMC4641492__F1 A lncRNA to repair DNA ATM HNRNPUL1 BRCA1 PMC8889147__F3 Network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease EBP ALB TPO ACHE CYP21A2 CYP1A2 DBH SLCO1A2 REST ESD OGDH ABCB1 PPT1 SQLE CXCR1 ADRB1 PTGS2 NR3C1 ADRB2 ACADSB NR1C1 NR1C2 PPARG ADRB3 GLS PMC6728077__F1 DCs modulate Tfh-2 responses through the IL-6/STAT3 signaling pathway CXCR5 GATA3 STAT3 PMC3496878__F4 Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling pathway in cell proliferation in solid cancer TSC2 TSC1 PTEN EIF4E EIF4EBP1 MTOR PMC3496878__F1 Signal transduction in solid cancer cells including hepatocellular carcinoma BAD MOS FOS EGFR APC PTEN RHO MTOR CRK NF1 FAP GRB2 CYC1 SRC JUN STAT3 CDC42 PMC8115630__F6 Relative abundance of respective enzymes involved in central carbon metabolic pathways in “Ca. B. sinica” based on proteomeic analysis HEL-S-26 PC HEL107 RPE SDHA SDHB HEL-S-162eP PMC8684084__F4 Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer MYB GSK3B MYC FGFR4 BCL2L1 PDPK1 PRKCA TNFSF6 MDM2 CDKN1B EIF4E HRAS IRS1 BRCA1 DDIT4 RHEB MLST8 RXRA TSC2 YWHAQ TSC1 MTCP1 CDK2 GRB2 STK11 BCL2 AKT3 CHUK BAD PHLPP2 PCK1 PTEN MTOR RPTOR CCND1 GNG11 RPS6 RBL2 CD19 FOXO3A CDC37 GYS1 RAC1 ITGB1 NFKB1 PKN3 PIK3CA SYK CRTC2 MCL1 SOS1 PMC3780793__F1 Genes identified in the phosphatidylinositol and hedgehog signaling pathways CDS2 GSK3B RAB23 PTEN PIP4K2A GAST BMP4 DGKB PRKCA PI3 CDIPT WNT4 SMO OCRL ZIC2 PIP5K1A PLCD3 PI4KB CSNK1G2 LCT PMC6690396__F3 Histone methylation-dependent DDR mechanisms RNF168 MSH6 SETD2 PMC3335850__F1 Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology BCL2 TNFSF13 FADD BAX PMC10229232__F1 Krüppel-homologue 1 regulates the development of Tuta absoluta and its cascade regulation pattern in the juvenile hormone signalling pathway RPL32 AGO1 CDC6 PMC11856996__F3 Inhibitory Effect and Mechanism of Hexanal on the Maturation of Peach-Shaped Phallus impudicus PI3 MIB1 HP PTEN ROM1 PMC8495394__F3 P38G in Cancer: From review to outlook ERBB4 F3 SUZ12 TF GATA3 PMC8495394__F1 P38G in Cancer: From review to outlook REST CCNE1 PMC6546959__F4 Proposed ternatin biosynthetic pathway HEL-S-62p GC GCG PMC3348384__F1 miRNAs and estrogen action AGO2 DGCR8 NCL DROSHA RAN FUS EWSR1 PMC9540541__F2 Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone TH ME1 PEX10 AMPD1 PMC8287254__F1 Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity VEGFA BDNF FNDC5 HCAR1 PMC11765629__F6 Metabolic pathway genes and metabolites altered in patients with MacTel SPTLC1 HEL-S-61p GCKR HEL-S-182mP MTR DHFR PSPH GCK SPTLC2 PHGDH PMC4727530__F2 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics BAD BRAF EGFR MTOR PMC2673958__F1 Role of Adenomatous Polyposis Coli (APC) and Microtubules in Directional Cell Migration and Neuronal Polarization APC RHO CDC42 PMC7539770__F3 Influence of the SRSF1 splicing factor on malignancy through AKT signalling TSC2 TSC1 EIF4E RHEB PMC8749970__F2 Tumor-Associated Macrophages in Hepatocellular Carcinoma Pathogenesis, Prognosis and Therapy IL10 CXCL10 CCL20 IL6 CCL2 CCL18 PMC11121235__F8 N-glycan metabolic pathway ALG11 ALG9 GANAB ALG13 GCS1 DPM2 DPM3 PMC8625973__F1 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy VASP RUNX3 AMOT NF2 ARHA LATS1 LATS2 ITCH PMC8625973__F2 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy NF2 CAMTA1 LATS1 LATS2 PMC8625973__F5 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy WWC3 LATS1 WBP2 LATS2 PMC8625973__F6 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy WWC3 LATS1 WBP2 LATS2 PMC8625973__F7 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy DGCR8 DROSHA DDX5 WBP2 ITCH PMC11986138__F1 Expression changes of genes associated with protein processing in the endoplasmic reticulum by the correction of LRRK2 by BAC DNA CASP12 PC ATF4 SVIP ATR RBX1 PAG1 PMC2713831__F5 Local Network Topology in Human Protein Interaction Data Predicts Functional Association INHBC PML IGSF1 HIPK2 SKIL TGFBR1 ENG SMURF1 BMPR2 ACVR2B ACVR2A SMURF2 INHA STRAP RNF111 SKI TGFBR3 pp6425 JUN INHBB INHBA TGFBI PMC10792990__F4 Mechanism of GB on independent risk factors for atherosclerosis TLR4 TG STAT3 PMC5985050__F8 Proposed mechanisms by which PPARB/D regulates VLDLR levels and hepatic steatosis.PparB/D deficiency may result in an increase in VLDLR levels and hepatic steatosis through several mechanisms FGF21 VLDLR FGFR1 ATF4 EIF2A TG PMC3560376__F2 The TLR9-Notch ligand (dll4) on Mycobacterium-dependent granuloma formation TH TLR9 CCR6 DLL4 CCL20 MYD88 CCL22 PMC4727530__F1 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics BAD BIK BMF HRK BAX PMC3060910__F1 Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells HES5 MAML1 NUMB HEY2 HES3 APC LFNG HES7 MFNG PMC2612083__F1 Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder CORT NMB CRH AVP TNF BDNF PMC4042299__F3 The role of epigenetics in the biology of multiple myeloma CDK4 WIF1 CDK6 SOCS1 STAT3 PMC8974835__F1 Pharmacological Rationale for Targeting IL-17 in Asthma FGF2 EGFR NOTCH1 C6 TRAF6 PMC6963149__F2 Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development OCEL1 DAO EGFR MDM2 SHE PTEN MTOR PMC5292133__F3 Network of the genes related with post-translational modification, cancer, and tumor morphology ELK3 CASP12 RTN2 LAMP2 CSDC2 INCENP MYC RIPK3 UHRF1 USP11 CDK7 BCAT1 PTCH1 RBMX TPMT CA12 ADK PMC8625973__F8 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy WWC3 USF1 WBP2 LATS2 PMC5292133__F4 Network of the genes related with cancer and DNA replication, recombination, and repair IL16 IFRD1 POLE PLK4 SRC MAOA PHLDA1 TFRC MED1 ARF6 PPIC RBL1 PMC9599649__F2 Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology DBI RAC1 CDC42 VAV2 PMC7614835__S1 Purine Biosynthetic Pathway, the Pathway Transforms PRPP (Phosphoribosyl Pyrophosphate) into IMP (Inosine Monophosphate) in 10 Biosynthetic Stepsa ASL PMC2928685__F1 Schematic diagram of the interaction of HH signalling on p53 and Nanog SOX2 PC SAG MDM2 SMO PTEN PMC11854632__F1 Effects of miR-21 on key signaling pathways involved in SCI, with a focus on axonal regeneration, apoptosis, and inflammation BAD NGF GFAP PTEN MTOR CNTF CASP3 CNTFR CCND1 ROR2 BDNF CASP8 FADD STAT3 BAX PMC3324922__F3 ALDH1A1 pathway TH FOS GSK3B SMAD6 SNCAIP DRD2 KCNB1 FZD9 LEF1 JUP SLC6A3 SLC18A2 PITX3 DVL2 FRAT1 PMC3324922__F4 NOS3 pathway TH COL18A1 ELF1 GSK3B ACTN2 ESAM ENG SLCO2A1 GATA2 IKBKB LIPE TNFSF10 AVP KLF2 THBS1 ACTN4 PMC6407676__F10 TGFB inducible epithelial-to-mesenchymal transition in renal cell carcinoma MMP2 SMAD2 TGFBR1 TGFBR2 SMAD4 PMC4108799__F3 HMGB1 binding to receptors and activating signal transduction pathway HMGB1 LTA TLR4 TLR9 CXCR4 MYD88 CXCL12 TIRAP PMC6895093__F15 Apoptosis adapted from KEGG (ID: hsa04210), the know targets were signed in red; (B,C) the insulin signaling pathway adapted from KEGG (ID: hsa04910) the predicted targets and other human proteins were signed in red TSC2 BAD ATM INS OTOF RHEB PMC4404103__F2 RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats CS PFKM HEL-S-32 MDH2 GOT2 FH ACO2 OGDH SUCLG2 HEL-S-133P SDHD HK2 PGAM2 SDHA HEL-S-281 SDHB ENO3 FBP2 SDHC HEL-S-30 DLD HEL-S-87p IDH3B SLC16A3 HEL-S-162eP HEL-S-68p SUCLG1 SUCLA2 PMC2967585__F9 Mechanisms involved in alcohol-mediated suppression of type I IFN pathway in human hepatocytes STAT1 SOCS2 SOCS3 STAT2 IRF3 TYK2 JAK1 PMC8449753__F1 How FGF23 shapes multiple organs in chronic kidney disease PTH1R FGF23 NR1i1 EPO PTH GALNT3 HIF1A ORAI1 PMC4001041__F1 Schematic illustrating NLR attenuation of canonical and non-canonical NFKB signaling IRAK1 NLRP12 NLRX1 TRAF3 RELB TRAF6 CD40 MYD88 NLRC3 PMC8027489__F1 PI3K/Akt/mTOR signaling and its main components TSC2 BAD TSC1 CDK2 MDM2 PTEN JAK1 IRS1 CENPO PMC11942534__F3 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism LATS1 MOB1A PMC11942534__F4 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism LATS1 MOB1A PMC8712723__F1 Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus PML TBK1 CGAS EPO TLR9 STAT2 IRF7 IRF9 IRF3 MYD88 IFNAR1 STAT1 ISG20 TYK2 CSA2 JAK1 PMC4169022__F3 Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma PTGFR PCK1 ESAM FFAR1 PPBP SP100 CLU BACH1 POMC PDE10A INPP5D VWF TACR3 IRF2 CENPA PTGDR NCOR2 SACS NR3C1 CD44 RXRG SMARCE1 TYROBP CTSG IXL SIRPA CDC20 HMMR PDE4B EGR2 BCL2 GNAS SMC4 SERPINF2 IRAK3 PMC5457776__F1 Insulin resistance in obesity TLR4 IRS1 PMC7216265__F3 lncRNAs affect glutaminolysis pathway in cancer ME1 ME2 OGDH TUG1 SIRT3 GLS PMC7216265__F4 Cancer glutaminolysis pathways through circRNAs IGF2 GLS PMC7216265__F1 Canonical glutaminolysis pathway ME1 PIG59 GPT GLS2 HEL60 HEL-S-32 MDH2 HEL-S-26 SLC7A3 ATF4 ASNS ACO2 PRODH ACLY GLS FASN PMC7216265__F2 miRNAs affect glutaminolysis in cancer MAX ACO2 GLS PMC3474187__F9 Methionine sulfoxide and methionine sulfoxide reductase (MSR) redox cycle CTH MSRA PMC9145045__F2 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison TBK1 TLR9 IRF7 TRAF3 RIGI IRAK4 IRF3 MYD88 TNF TRIM25 TLR3 TLR8 TLR7 MAVS PMC9145045__F3 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison ISG15 IRF9 IFNGR2 TYK2 DDB1 PMC6715589__F2 APP regulation of mitochondrial OXPHOS metabolism BAD APP INSR PMC7409348__F5 Graphic representation of signaling pathways that promote gastric cancer PTEN BDNF PMC4949263__F2 Horizontal cell fate and cell type formation PTF1A FOXN4 LHX1 ISL1 PMC6503447__F9 Prospective model for clarifying the role and regulation of ATG5 and ATG7 on autophagy and ER stress ATF4 EIF2A DKFZp686F0183 PMC6199358__F1 (Left) In the “off” state, Beta-catenin binds with glycogen synthase kinase 3B (GSK3B), axin2, adenomatous colon polyposis protein (APC), and casein kinase-1 (CK- 1) APC LRP5 CCND1 LRP6 AXIN2 PMC5559174__F14 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome ELF2 IGF1 IL6 RHO MTOR SIRT1 RHEB PMC6199358__F2 The Wnt/Beta-catenin and other signaling pathways LEF1 APC GSK3B PMC8498718__F3 RNA-seq profile of African American men with a clinically localized prostate cancer LRP2BP SELENOW UVSSA PMC7506056__F9 Aucubin attenuates liver ischemia-reperfusion injury by inhibiting the HMGB1/TLR-4/NFKB signaling pathway, oxidative stress, and apoptosis IL16 MYD88 IRF-1 PMC4288522__F1 Intracellular signaling of mTORC1 and mTORC2 NF1 TSC2 TSC1 NF2 PTEN DEPTOR IRS1 SGK1 RHEB PMC4116802__F2 Inflammation induces B cell activation BCR MYD88 STAT3 PMC3293571__F7 EMT downstream of TGFB and HMGA2 HMGA2 ZEB2 PMC6628971__F1 Molecular mechanisms of the cGAS/STING pathway as a senescence-associated DNA damage sensor and inflammation trigger TBK1 CGAS IRF3 RPE PMC11975009__F2 VPS35 in Neurodegenerative Diseases BACE1 VPS35 SLC4A11 CDK5 LRP6 HEL-S-130P FUS PMC9019781__F1 WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease EPO VHL WT1 PMC6748047__F2 Protein pathway analysis using serum proteins present in healthy controls and/or AA patients PRKCZ HGF MPO TEC SGTA DKK1 TNLG2B DKFZp686L24211 DDR2 DKK4 PPIF NID2 SELL FRZB TNFRSF4 BMP10 KREMEN1 PDGFA CNTN4 CCL17 BCL2 THBS1 SELP PARD3 PMC8437933__F7 Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway FST PMC6705454__F8 Modulation of IGF-1R expression levels is sufficient to restore the AKT/CREB and ERK/Elk-1 intracellular signaling pathway activation profile, resulting in SMN expression increase in SMA mice IGF1R IGF1 SMN1 PMC7830527__F2 Proposed IFN-Gamma-dependent mechanisms of hyperprogression NLRP3 IDO1 TLR4 CXCL5 IL8RB PMC7830527__F3 Proposed CD38-dependent mechanisms of hyperprogression ANGPT2 ADORA2A IGF1R IGF1 IGF2 UNK HIF1A PMC3233625__F3 Pleiotropic functions of EAPII/TTRAP/TDP2 SMAD2 CD40 PMC5963710__F7 Nonhuman primate kidney transcriptome in fetal development ROCK2 BTRC APC GSK3B LRP5 MYC CER1 SMAD4 LRP6 SKP1 ARHA RBX1 WIF1 DVL1 NLK DAAM1 LEP SIAH1 PSEN1 PPARG PMC4239504__F2 Molecule-mediated signal pathways in the propagation of liver cancer during liver regeneration SMAD2 SMAD4 MTOR SMAD1 DKFZp781O1323 PMC9559313__F1 Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies ALDOB AIP ENG HEL-S-87p HK2 PMC4191248__F2 Pancreatic cancer pathway diagram page EGF ANO7 PTEN TGFA PMC3698421__F10 Schematic presentation of the Wnt signaling pathway APC LRP5 LRP6 PMC3976613__F2 Non-selective autophagy regulation during diabetic nephropathy (DN) TSC2 RICTOR TSC1 IGF1 UVRAG RHEB PMC9164466__F7 FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion IL1B GSDMD PMC3712052__F1 Analysis strategy (–) to identify the putative regulatory effect of GWAS candidate () on FRMD3 regulation (), linking the gene to transcriptional regulation of the BMP pathway (–) and DN and suggesting a hypothetical regulatory model () FRMD3 MAP3K7 PMC11392662__F8 Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells DRD2 STAT3 PMC7528617__F6 Analysis of HIF-1 signaling pathway EPO HEL-S-11 VHL ENO1 EIF4E STAT3 HEL-S-162eP PMC4191248__F3 Hypoxia-inducible factor pathway OS9 EP300 VHL SAT2 AMT HIF1AN PMC4191248__F6 Renal cell cancer pathway FH ACD SDHD PMC7311976__F1 Wnt/Beta-catenin signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 PORCN PMC7311976__F4 Ubiquitination in the Wnt signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 HUWE1 RNF146 SMURF1 NEDD4 SIAH1 SMURF2 NARF PLEKHA4 FANCL ITCH PMC7311976__F5 Deubiquitination in the Wnt signaling pathway USP4 APC LRP5 LRP6 USP25 USP34 USP14 CYLD USP9X USP47 USP6 USP44 USP51 PMC8821659__F4 Comparative Study of Bacillus amyloliquefaciens X030 on the Intestinal Flora and Antibacterial Activity Against Aeromonas of Grass Carp ABAT PDK2 OTC CIT PMC3198061__F3 In individuals with high macrophage aggregation around dead adipocytes as CLS, activation stimuli such as IL-1, lipopolysaccharide (LPS) and lipopolysaccharide binding protein (LBP), and TNFA bind to their appropriate membrane receptors CD14 TLR4 MMP9 LBP IRS1 PMC9314411__F8 Proposed model of the UVB-triggered biochemical pathways in human dermal fibroblasts EGF ATM BCL2 BAX PMC9031497__F4 Impact of Maternal Feed Restriction at Different Stages of Gestation on the Proteomic Profile of the Newborn Skeletal Muscle PIG59 HEL-S-30 DLD PFKM HEL60 HEL-S-162eP HEL-S-26 PDC PDHA1 ENO2 OGDH ECHS1 DLAT AGL PMC449769__F7 A model connecting telomere damage signalling and senescence-associated replicative arrest ATM ATR H2AX PMC11832533__F9 Brief Introduction to the Functions of lncRNAs (Wilusz et al MCM5 PLK1 TUG1 EZH2 RAB10 PMC5411440__F1 Cellular and molecular pathogenesis of Helicobacter pylori infection in gastric carcinogenesis APC GSK3B CD44 SMAD4 MYD88 HIF1A COX2 TLR4 FOV RASSF1 MAX BCL2 CDH17 STAT3 PMC7649776__F4 Psychiatric and cognitive SNPs mark eQTLs that are associated with gene expression within the neurotrophin signaling pathway BAD NGF FRS2 GRB2 SHE APP TRAF6 ARHA CRK IRS1 CDC42 BAX PMC3188357__F2 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), is the major genotoxic heterocyclic amine generated from cooking meats at high temperatures CYP1B1 CYP1A1 PHIP CYP1A2 PMC8173334__F1 Diabetes and Cardiovascular Complications: The Epidemics Continue PTMS IRF7 IRF9 IRF4 PMC9174413__F7 Comparative proteomic analysis on chloroplast proteins provides new insights into the effects of low temperature in sugar beet PC PRX PMC3875938__F1 The mechanisms of Wnt/Beta-catenin pathway repression by 1,25(OH)2D3 in human colon carcinoma cells NR1i1 LRP5 CCND1 LRP6 TCF4 PMC8083961__F3 Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration ERBB4 IGF1R IGF1 WEE1 ERBB2 EIF4E CDC2 MTOR SIRT1 PMC8268912__F1 Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment NF1 TSC2 ULK1 TSC1 DEPDC5 PTEN EIF4E RHEB PMC2757648__F3 Interferon response genes are coordinately upregulated relative to the rs17445836 allele of IRF8 AOAH PML IFIT2 PIN1 MXD1 CHUK LRCH4 CTSS TLR9 MX2 CSF1R TLR4 IFNA2 IRF7 S100A9 IFNAR1 AGER SPI1 S100A8 LILRA2 IFIH1 SOCS1 INHBA NCF2 GPR65 IFIT1 PMC10984535__F6 Pathway dynamics of islets during diabetes progression CCK RIPK1 CACNA1B FOXO3A SMAD2 FKBP5 PTEN CCKAR FOXO1 HK2 PMC11354572__F1 Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status CGAS TLR7 TLR9 IRF7 IRF3 MYD88 AIM2 TLR3 MAVS IFI16 PMC7943466__F4 General mechanism of MP formation, its mode of action, and the proposed possible impacts of diets on MPs that could be linked with CSVD PC VCAM1 RHO TF PMC10532491__F5 EGFR signal transduction pathway—an overview (modified after [94]) RET BRAF ALK EGFR MDM2 PIK3CA PTEN RB1 MTOR AXL FUS PMC3096494__F1 Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells CD14 TLR4 MEIS1 PBX1 SP1 PMC4061247__F3 Nuclear Trafficking in Health and Disease RANBP1 LRPPRC EIF4E PMC8502122__F1 Comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori GPT PURB PMC10532491__F2 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer EGF HGF ERBB2 EGFR GRB2 TGFA PMC10532491__F3 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer STAT1 EGF AREG EGFR STAT3 PMC3614848__F2 STRING interaction for proteins studied to find relevant networks in RCC KDR SLC2A4 SLC2A2 BIRC5 SLC2A3 MDM2 VHL VEGFA BCL2 CA9 HIF1A BAX PMC11941256__F1 BMP signaling pathway BMP6 BMP2 BMP5 BMP7 RHO BMP4 PMC7957592__F7 Influence of TP53 on FAM72 paralogs directly regulates the cell cycle in cancer CASP6 FAM72D FAM72B FAM72A BCL2L1 PTEN RB1 TFDP1 CHEK2 ATM E2F2 MDM2 CASP9 RBL2 RBL1 BAX MYBL2 BAK1 DIABLO CHEK1 CASP3 CDK2 BCL2 MCL1 SRGAP2 ATR CYCS PMC9119177__F7 Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways CD14 HAMP TRADD ATM TNF MX1 PMC5818912__F4 The ADAM17/EGFR axis AREG EGFR NOTCH1 ADAM17 PMC3674623__F6 Effect of sodium ferulate on caspase cascade apoptosis and IKK/NFKB pathways induced by TNF/TNF receptor TRADD TNF TRAF2 FADD PMC5818912__F7 ADAM17/EGFR signaling an important player in CF and COPD lung disease AREG EGFR STAT3 PMC5412308__F4 DEGs protein–protein interaction (PIP) network complex and modular analysis GCNT3 CDCA5 P2RY1 CCNA2 AGTR1 BIRC5 AHCYL2 CENPF AQP8 BEST2 UBE2T CXCL3 SERPINB5 KCNMA1 CLDN2 SLC4A4 SCN9A PTGS1 KRT6B SOX9 EPHB3 UGT2B15 ACSL6 SCNN1B SLC9A9 MMP7 S100P COL4A6 ZG16 MT1E CDCA7 CEP72 FAP OSBPL3 GHR TCN1 ONECUT2 EZH2 HEPACAM2 KIF15 BCHE ENC1 DLGAP5 CXCL11 OXGR1 CENPA CKAP2L MMP10 SETBP1 HELLS MYOT PAPSS2 CKS2 TCEA3 POLR1D ABI3BP CHP2 LRRC8E LGI1 GALNT6 SLC26A2 ODAM CENPE FABP6 POU2AF1 PIGR PRKCB CCL20 CXCL12 CXCL1 SLC5A1 DCLK1 PCK1 ADAM12 LRP8 DES LPAR1 DBF4 GNAI1 PCSK9 SLC12A2 CLCA1 RRM2 GDF15 CXCL6 CCL28 IRF4 CHI3L1 KIT RUNX1 ITLN1 NR3C1 NR3C2 HCTP4 HSD17B2 SKA3 FOXA2 NMU MND1 NCAPG NEK2 HEL164 KIF20A MMP11 CDKN3 TRIB3 MEIS1 ITGA2 LMNB2 CCL19 GINS2 SFRP4 AKAP12 HSD11B2 CDC45 LAMA1 E2F7 HMMR MUC4 BRCA2 TOX COL10A1 SLC7A11 TTK NOX4 ERCC6L CDCA2 PPBP GCG CEACAM1 GNG4 NUF2 LIPG CENPW CCNB1 KIF18A ESCO2 TESC CDC2 SULT2B1 RAD51AP1 GREM2 SPC25 CLDN1 MAD2L1 PF4 CXCL2 EPHB2 INHBA PMC3202828__F5 Cif hijacks several and various signaling pathways by inhibiting the ubiquitin ligase activity of CRL ARHA CDT1 PMC6065367__F8 Proposed mechanism for TSPO ligand-induced ATP release TSPO2 PBR PMC12215448__F4 Interaction of CD8+ NKT-like cells, CD8+ T cells and GDT cells with NK cells TNFRSF1B CD48 CD244 TNF PMC5566109__F5 CircRNAs and the related signaling pathways in human cancers PIK3CD PRR11 CDK2 EGFR TCF2 CDK6 ITCH CCNE1 PMC9607849__F1 Development of a Chiral Supercritical Fluid Chromatography–Tandem Mass Spectrometry and Reversed-Phase Liquid Chromatography–Tandem Mass Spectrometry Platform for the Quantitative Metabolic Profiling of Octadecanoid Oxylipins ALOXE3 GLA PMC11953509__F7 NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/Beta-catenin signaling pathway in colorectal cancer APC NEK2 CCND1 PMC8660639__F7 Proposed mechanistic scheme of PCID2 in promoting the canonical Wnt signaling pathway in colorectal cancer PML CCND1 PCID2 PMC3724648__F6 Model showing the effects of PP2A in SLE T-cells ELF1 TNLG8A SUI1 SP1 PMC5964874__F4 MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs CD14 EGF NGF MOS FLNA EGFR TRAF6 TNF NLK MAX HP GRB2 JUND ECSIT RAF1 BDNF TRAF2 MEF2C PMC4571158__F2 A schematic presentation of secreted, endocytic, and signaling pattern-recognition receptors HEL-S-62p C4B_2 C4A PMC11671673__F8 Schematic diagram about working model of YTHDC1 EIF3A RPL37 PIK3R3 YTHDC1 RXRA PMC6345383__F2 PDA cells have a remarkable ability to adapt to nutrient fluctuations and targeted therapies ME1 GOT2 HEL-S-32 GLS PMC12068294__F2 Bioactivities of stem cells cultured on fish-derived biomaterials TLR4 GPR32 GPR18 PMC5454963__F1 Proposed action mechanisms of glutamine in intestinal cells STAT1 STAT4 MTOR STAT3 PMC4148147__F7 Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells PDC TLR7 IRF7 IRAK1 TRAF3 F7 MYD88 TNF MAVS PMC9406534__F3 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer TBK1 IRF3 TRAF2 MAVS PMC3617098__F1 Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 SSB PARP1 PMC3620319__F3 An Integrated Approach to Uncover Driver Genes in Breast Cancer Methylation Genomes E2F2 TRAF2 HDAC1 PMC10937645__F8 Proposed model of the recognition of bacteriophage DNA by the animal immune system TBK1 CGAS TLR9 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 PMC6378054__F1 UPR signaling cascade ATF4 EIF2A GLS PMC9406534__F2 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer CAP2 CAP1 RELB TRAF2 PMC10305623__F1 11-oxygenated androgens in prostate cancer PC HSD3B1 SRD5A2 HSD17B2 AKR1C2 HSD17B6 PMC4922205__F2 BCR-ABL1 Signaling Network BCR GAB2 COIL MTOR SKP2 PMC3076281__F2 Sphingolipid effects on intrinsic and extrinsic apoptotic pathways BAD TRADD TNF FADD BAX PMC3076281__F3 Effect of sphingolipids on the PI3K/AKT pathway BAD MDM2 CASP9 PTEN MTOR PMC6274856__F1 Cartoon showing the major signaling pathways targeted by phytochemicals in cancer PTEN RAF1 MTOR EIF4B PMC6862031__F5 Summary of altered metabolic pathways and regulatory mechanism of rFIP-nha against A549 cells TIGAR TSC2 SCO2 GLS2 PTEN MTOR HEL-S-162eP PMC7856101__F2 Gut Microbiota in Epigenetic Regulation of Colorectal Cancer TLR4 STAT3 PMC7926694__F6 Emerging effect of ferroptosis in malaria immunity GPX4 STEAP3 SLC7A11 GLS2 TF PMC9283764__F4 Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0) HCST RAB14 AHR TBP NR1C2 CENPE FGF13 SCARB2 TNF PPARG SNAP29 PMC8065509__F2 LTBR signaling pathway in lymphatic endothelial cell (LEC) TRADD TRAF3 TRAF2 LTBR PMC3627549__F6 Decreased Hepatotoxic Bile Acid Composition and Altered Synthesis in Progressive Human Nonalcoholic Fatty Liver Disease CYP27A1 GCA CYP8B1 AKR1D1 CYP7B1 BAAT HSD3B7 PMC6098968__F1 Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums BAD FOS GSK3B MYC PTEN MTOR IRS1 RHEB TSC2 RICTOR MDM2 GRB2 APP CASP9 JUN PMC9036297__F4 Uncovering Novel Pre-Treatment Molecular Biomarkers for Anti-TNF Therapeutic Response in Patients with Crohn’s Disease RHOD BAD CRK PMC3736540__F1 Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour TLR4 IRF3 MYD88 PMC5580529__F3 Proposed model for the regulation of synaptic restructuring by Wnt during learning (from ) APC GSK3B PMC8385607__F5 Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease PIM1 CRAT MTOR CEBPB PMC7532113__F1 ERBB family comprises four receptor tyrosine kinases including the epidermal growth factor receptor (EGFR) IGF1R GRB2 NRG1 MTOR PMC8746762__F12 The mechanism behind the inhibition of the TGF-Alpha-induced HCC cell migration by raloxifene and bazedoxifene EGFR TGFA PMC11901933__F8 Reparative potential of LF in UVB-exposed HaCaT cells SMAD2 HAS2 PMC3666377__F3 Functional Beta-cells respond to increasing glucose levels by increasing insulin secretion PDX1 PTF1A RFX6 GCK HNF1A NEUROD1 GLIS3 TCF2 PAX4 KIF11 FOXP3 PMC9240200__F2 Vicious Cycle: In Severe and Critically Ill COVID-19 Patients TLR4 ACE2 STAT3 PMC7336871__F2 Physical approximation of APP and BACE-1 - a key event in Alzheimer’s disease pathogenesis BACE1 NUMB SNAPIN SNX15 BIN1 APP PACS1 SNX4 SNX27 CD2AP PMC8888693__F1 Using a Systems Approach to Explore the Mechanisms of Interaction Between Severe Covid-19 and Its Coronary Heart Disease Complications TH IGF1 VCAM1 CROT TNF PMC3319201__F3 Primary therapeutic targets in the Ras downstream signaling pathway NF1 NF2 RHO PTEN MTOR PMC12104164__F3 Signaling pathways related to fibrocartilageThe complex network of interrelated signaling pathways is involved in the generation of fibrocartilage, including TGFB/SMAD, WNT/Beta-catenin, Hippo, PI3K/AKT, and NFKB TEAD3 LEF1 RELA TEAD4 LATS1 PTEN COIL MTOR LATS2 TF TEAD2 PMC3559989__F6 Bayesian regulatory network and optimal regulatory pathway of p42.3 protein ROCK1 VHL RHO PTEN SP1 S100A4 HEL-S-43 PMC7946937__F4 Rewired signal pathways by deregulated Myc in cancer and its related components available for synthetic lethality BUD31 CDC2 PRKDC XBP1 PMC4837572__F3 Synaptic transmission: lipid-protein interactions MARCKS GSK3B SRC NCS1 CDC42 PMC8491037__F1 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint DAG1 PC LPA HEL-S-5 PMC8495584__F3 Research progress on evodiamine, a bioactive alkaloid of Evodiae fructus: Focus on its anti-cancer activity and bioavailability (Review) MTOR STAT3 BAX PMC4707441__F2 Tetraspanins organize the T-cell immunological synapse CD9 PLAT CD151 APC CD82 CD80 RHO CD81 PMC5378187__F2 Plant-parasitic nematodes: towards understanding molecular players in stress responses PRX PMC4197207__F3 PRR signaling in testicular cells TLR5 TLR4 MYD88 TLR3 PMC8491037__F7 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint PC LPA HEL-S-5 PMC10723546__F3 Biological pathways in ccRCC PBRM1 BRAF RPL22 DKFZp781B1423 ARID2 PTEN HIF1A MTOR CDKN2A FBXW7 SMARCA4 ATM MDM2 HEL-117 EZH2 ELOC VHL USP20 PTH MAP2K2 UHRF1 SUZ12 ARID1A EED TSC2 CREBBP EP300 MAP2K1 RBBP7 ATR SETD2 PMC8024119__F5 Enhanced activity of the RAS-MAPK signaling pathway due to the loss-of-function mutation of the NF1 gene and mode of selumetinib action NF1 BRAF GRB2 RAF1 PMC9185151__F1 InterferonA and its effects on cancer cell apoptosis STAT1 STAT2 IRF9 TYK2 JAK1 PMC5590790__F1 Molecular mechanism underlying cardiovascular diseases associated with the changing of intracellular Ca2+ through TRPCs TRPC6 TRPC3 TG PMC3661940__F1 Intrinsic somatodendritic and presynaptic modulation of action potential (AP) firing and transmitter release in 5-HT neurons CCK CX3CR1 GALR3 GALR2 PMC8431803__F1 Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier CYP2B6 ChAT ACHE CP CPO PMC5445933__F3 Main pathways altered in GEMMs of cutaneous melanoma RET HGF CDK2 MDM2 PTEN MTOR PMC6338564__F5 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses NAMPT MYC PRODH SIRT1 GLS PMC6338564__F6 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses ATM MYC PTEN PMC4641522__F4 Paradigm for testing the multiple independent mechanisms that reinforce IDO1-mediated immunosuppression in malignant glioma IDO1 SOCS3 SLN APC IDO2 FOXO1 PMC8082504__F10 Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway GPX3 IL18 NFE2L2 PIK3CA BDNF HMOX1 NTRK2 PMC5154770__F1 Naïve T cells are predominantly oxidative and constantly monitor their environment for immune insult IL15 MYC MTOR PMC7793984__F1 LMP agents and biological factors that induce lysosomal rupture and cell death NPC1 PC LAMP2 PMC3047044__F1 Simplified schematic version of the epidermal growth factor receptor (EGFR) signaling cascade EGF BRAF EGFR GRB2 TGFA PMC2817383__F4 Putative host signaling pathway induced by Y STAT2 BAK1 LIF IL33 DUSP16 PTGES MIP LPP MYD88 STAT3 PMC6423493__F5 GRP78 mediates hypoxia-induced EMT through smad2/3 and SRC/MAPK signaling SMAD2 SRC PMC9085754__F4 MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach SPARC EGR1 RUNX1 FOS SMAD2 CD44 TCF7L2 CEBPA HIF1A FOXD1 NFKB1 RELA TFAP2C JUND JUNB SP1 NFIA GATA3 PMC6251060__F1 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease ULK1 ATG12 ATG3 AMBRA1 BCL2 ATG101 UVRAG STX17 ATG10 DEPTOR DKFZp686F0183 PMC6715306__F1 Extrinsic and intrinsic cues regulate the oligodendrocyte program PDGFRA ID4 MBP NRG1 PTEN RHO MTOR HES5 FYN IGF1 GIG8 OLIG1 SHH YY1 SOX5 SOX10 BDNF TCF4 PMC6251060__F4 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease MFN1 PINK1 FUNDC1 PMC4947555__F3 Histological chorioamnionitis shapes the neonatal transcriptomic immune response CEBPE FOXO3A SPI1 PIM2 ANXA2 PMC8898355__F1 Ferroptosis by Amino Acid Metabolism in Cancer GPX4 FES MTOR PMC9370123__F2 Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies RFC1 TH TPH2 PMC6042401__F8 Alterations in CREB signaling TBP GRB2 POLL POLI PMC7391667__F3 Direct pathway of m6A to regulate transcriptome a Two possible mechanisms of eIF3 regulating mRNA translation initiation YTHDF2 METTL14 YTHDF1 ELF3 YTHDC2 YTHDC1 MGA PMC8638425__F4 Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer EGR1 REN LHPP MYC HIF1A CDKN1C SUZ12 EED CDKN1A BCL2 LZTFL1 MCL1 EZH2 EZH1 PHF19 MVP PMC7510328__F2 MET and/or RON activation, signaling pathway, and biological consequence IGF1R HGF APC EGFR GRB2 VHL BCL2 MCL1 MTOR PMC3744227__F1 Chemopreventive potential of natural compounds in head and neck cancer EGF RELA EGFR GSK3B MDM2 MTOR PMC6409601__F4 Hypermodification of m5C34 in anticodon of cytoplasmic and mitochondrial tRNAs FTSJ1 ALKBH1 NSUN2 NSUN3 PMC2666381__F1 TLR signaling and the role of epithelium in corneal innate defense TLR5 TLR9 IRF7 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 LTA TLR7 TLR4 CSA2 MAL PMC9622788__F1 Regulatory necrosis in traumatic brain injury ME1 TRADD CYLD GSK3B CHMP4B ARC TRAF2 MLKL PMC9622788__F2 Regulatory necrosis in traumatic brain injury NLRP3 TLR4 PGAM5 ACE2 AIM2 IL1B GSDMD PMC4870750__F8 Seasonal bias in toll-like receptor (TLR) signalling pathway TBK1 TRIL IKBKE IKBKG TLR9 IRAK1 MAPK3 MAPK14 TRAF3 TRAF6 IRAK4 MYD88 MAP2K6 RIPK1 opn TLR5 CTSK IRF7 MAP3K7 IRF3 MAP3K7IP1 TLR3 IKBKB MAP2K1 NFKB1 PIK3CA MAPK11 FADD TIRAP PMC4260725__F2 Major signaling pathway regulation and core machinery of autophagy ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 PMC9622788__F4 Regulatory necrosis in traumatic brain injury TRADD RIPK3 BNIP3 GSDMD PMC1064894__F3 Toll-like receptor (TLR) signaling pathways TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TLR1 TLR3 TIRAP PMC10380946__F3 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAD TRADD APAF1 EGFR ABO ABCA1 MTOR TRAF2 FADD BAX PMC12066790__F10 Oncogenic mechanisms of HTLV-1 in adult T-cell leukemia/lymphoma BIRC5 MYC CCR4 TIGIT HBZ LAG3 HAX1 FBXW7 FOXP3 CARD11 RNF8 IRF4 PCNA STAT3 PMC10380946__F4 Illustrates the apoptosis mechanisms triggered by DHA BAD OSGIN1 SDC1 TRADD EGFR PTEN TNF MTOR XBP1 TLR4 APAF1 ATF4 EIF2A FADD STAT3 PMC10380946__F1 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAD APAF1 BAX PMC6899527__F3 Single-Cell Sequencing of ChAT/vAChT-Positive Cortical Cells and Analysis of Their Expressed TranscriptsExpression values were normalized (0–1) for each dataset CHRNA5 CHRNA7 GBX1 SLC18A3 RBFOX3 SLC5A7 LHX6 LHX8 ACHE IL6R VIP CHRM5 GBX2 NKX2-1 NGFR CNTFR CHRM2 BCHE NTRK2 ChAT SST NTRK1 LIF GFAP AIF1 CHRNB4 CHRNB3 CHRNA3 CHRNA2 GAD1 CHRNA6 ISL1 CNTF CHRM4 CHRM3 COLQ CHRNA10 CHRM1 OLIG1 TYK2 IL6ST PRIMA1 JAK1 TF CHRNB2 PMC10380946__F2 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAD APAF1 H2AX FADD BAX PMC10380946__F7 ARA on apoptotic death pathways APAF1 HEL-S-28 EIF2A FADD PMC8187247__F1 Antiviral strategies targeting herpesviruses PDGFA NECTIN2 PMC10380946__F5 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAD APAF1 PTEN FADD BAX PMC10380946__F6 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAD APAF1 BAX PMC6216032__F4 Smad-dependent/independent transforming growth factor-beta signaling pathways ATF3 ARHA TF PMC10531214__F3 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications STAT1 STAT2 STAT4 TYK2 IL6ST JAK3 JAK1 STAT5B STAT3 PMC10531214__F4 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications LIF IL24 PMC10295928__F6 MiRNA-assisted immunotherapy CCL4 PTEN JAK1 PMC11625190__F1 Biosynthetic pathway of 1-phenylethylisoquinoline-derived PIAs DDC ADH7 PMC10295928__F5 MiRNA-assisted targeted therapy MUC1 IGF1R HGF IGF2 EGFR CD44 MTOR IRS1 RHEB opn SHH HDAC2 AXL PMC6965651__F8 ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD CASP3 MKRN1 FADD PMC3601164__F3 Links between Toll-like receptor 4 and breast cancer TBK1 TLR4 TRAF3 IRF3 MYD88 PMC8488570__F3 The CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting CCR2 CCL2 MTOR STAT3 PMC4277955__F1 Interleukin-22 signaling pathway TYK2 JAK1 STAT3 PMC3601164__F2 Links between Toll-like receptor 4 and breast cancer TLR4 IRAK1 TRAF6 MYD88 PMC8909150__F1 Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia NF1 GAB2 GRB2 CBL PMC11976435__F1 Wnt/Beta-Catenin signaling pathway APC LRP5 LRP6 DKK1 PMC11851563__F2 Beta-Catenin and DNA repair pathways TDG GSK3B FEN1 SIAH1 PKP2 ATM MSH6 RAD51 MSH3 MSH2 HMGB1 MYBL2 RUVBL1 PARP1 BRCA1 FZD5 PMS2 PRMT1 CDX2 BRCA2 ERCC1 XPA ATR PCNA TCF4 PMC8600818__F9 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1A/miR-210/Rad52 pathway ATM RAD52 H2AX PMC6071762__F1 Biosynthesis of glycerophospholipids and sphingolipids in mammalian cells PC PGP HEL-S-5 PMC6658087__F9 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice CS KEAP1 TIMM23 HEL-S-104 MTFP1 DNAJC15 TIMM50 HEL-S-5 SLC25A18 SLC25A51 MFN2 SLC25A3 SLC25A22 TOMM5 SLC38A4 SLC2A4 MPC1 CYC1 SLC27A1 MPC2 HK2 CYCS CCS PMC6293111__F6 Model depicting the molecular function of Lsm12 POLN PCNA LSM12 PMC11851563__F1 Canonical Wnt signaling pathway APC GSK3B PMC6071762__F5 Apparent unidirectional fluxes of the LTP-mediated inter-organelle transport of lipids are indirectly coupled with metabolic reactions of lipids PC PCTP OSBP PMC11976435__F2 Non-canonical Wnt signaling pathway NLK DAAM1 DAAM2 LRP5 LRP6 ARHA PMC6658087__F5 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice IKBKG SNAI1 MYC NFKBIZ HIF1A WT1 IFNG ATP1A4 POU2F1 IL17RA IL17A SERPING1 NOS2 SP1 FCGR2B ABL2 FOSL1 YBX1 TP63 LIF ABI2 TNF C3AR1 BRCA1 GATA2 ANGPT1 EDN1 VEGFC NFKBIA GJA1 TBXA2R SYK CD93 REL IRAK3 ADRB3 STAT3 PMC3108205__F4 Delay in apoptosis at 9 hr BAD CAST APP MCL1 CAD TNF DIABLO HTRA2 BAX PMC4909382__F7 Schematic depiction of the antiapoptotic conditions including the PRL signaling pathway in young RPE versus the proapoptotic conditions in aging RPE SIRT2 PRLR RPE PRL PMC3720859__F4 Capacity of Aptamers to Trigger Immune Activation in Human Blood LBP APP LPP MYD88 TIRAP PMC2920202__F2 Spatial-temporal signals determine the fate of activated CD8+ T cells IL15 GIG8 CD27 TNLG8A CD2 CD40 PMC2785495__F3 Response of heterogeneous ribonuclear proteins (hnRNP) to ionizing radiation and their involvement in DNA damage repair ATM MDM2 ATR PMC3490606__F1 Reactions involved in the flux of fatty acids into PDC PC LPA HEL-S-5 PMC1855986__F9 ATM-Mediated Transcriptional and Developmental Responses to Gamma-rays in Arabidopsis WEE1 ATM ATR CYCS PMC8013731__F8 Toll-like receptor signaling pathway and NF-kappa B signaling pathway regulated by the S100s alteration in HCC CD14 CTSK LBP CD40 IRAK4 RAC1 TNF FADD TLR3 CPO ELL PMC2833340__F1 Plane facts of PCP in the CNS VASP PTK7 ROR2 ATR CTHRC1 CDC42 PMC6689252__F6 Extinction-dependent network of genes in morphine-treated rats FLNB PARG DRD2 CNR1 GMFG VTCN1 ZDHHC8 DEFB114 EMCN CCL27 NTRK2 PER2 ChAT OPRD1 CYP46A1 MMD PEBP4 SHE FUT4 PRKG1 GAP43 RHEB ADCYAP1R1 ASAH2 NTF3 CREM GRIA4 TRPC3 REL GFRA2 RASGRP4 PMC3219092__F3 Nox regulation of the PI3K/AKT pathway BAD SRC PTEN FOXO1 PMC6757184__F1 Wnt/Beta-catenin signaling as a useful therapeutic target in hepatoblastoma EGF GSK3B FHL2 SLC38A1 PMC3825518__F1 From Evolution to Revolution: miRNAs as Pharmacological Targets for Modulating Cholesterol Efflux and Reverse Cholesterol Transport PREB ABCG1 LDLR ABCA1 TG PMC4284388__F3 Platelet signaling induced by GPIb-IX-V and required for AIIbB3 activation PI3 LYN VWF SRC SYK PLCG2 RAC1 PMC4172484__F7 Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling HES1 PMC4882019__F3 Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification STAT1 CASP3 DGIC FOS CD163 BIRC3 APOL6 CD93 KNG1 PPBP CPVL PMC8901678__F1 Hepatic glucose, lipids, and amino acid metabolism ME1 HEL-S-26 MTOR TG MAL PMC8901678__F2 Systemic iron homeostasis EPO IBRDC1 SLC39A14 PMC8901678__F3 Iron metabolism in the liver ERFE BMP6 EPO STEAP3 SLC25A37 FTL SMAD4 TMPRSS6 HFE IL6 FBXL5 TFR2 BMPR2 ACVR2A IBRDC1 SLC39A14 TF STAT3 MON1A PMC4518307__F5 Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst SLC6A13 HK3 SLC25A10 PGM2 PFKL HEL-S-32 GOT2 MAX SLC6A12 F2 ENO2 SLC3A2 L2HGDH PMC8037590__F1 PI3K and MAPK signalling pathways BAD PTEN EIF4E MTOR DEPTOR RHEB TSC2 RICTOR TSC1 MDM2 GRB2 RPS6 MLL2 BAX PMC8037590__F2 Insulin-mediated feedback loops following PI3K/mTOR inhibition GRB2 PTEN EIF4E RPS6 MTOR DEPTOR PMC8387356__F1 Influence of diets on metabolites and the epigenetic machinery PRC1 OGA OGT PHF6 PMC2804114__F1 IR and IGF family signaling pathway TSC2 MTOR RHEB PMC7696079__F2 Underlying mechanisms of LND-mediated antitumor activity SDHC HEL-75 SDHD SDHA BAX PMC6888321__F3 Cell signaling pathways activated in osteogenesis and angiogenesis models: Wingless-related integration site (Wnt) pathway, bone morphogenetic protein (BMP) pathway, and fibroblast growth factor (FGF)/platelet-derived growth factor (PDGF) pathway RUNX2 SCUBE3 SMAD1 DKFZp781O1323 PMC6748367__F6 KEGG Pathview readouts of DEX vs Control-associated differential gene expression ERBB2 APC EGFR PIK3CA PMC8633576__F13 Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3B Pathway and Activating Autophagy in Gastric Cancer GSK3B PARP1 CDC2 BAX PMC6468357__F4 FOXK2 role as an oncogene in cancer AGA CCND1 FOXK2 SOX9 PMC8640960__F3 Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension SOCS3 TNFRSF12A TNFAIP6 IFITM2 MAOA CCL2 IFNG CYP27A1 MT1E TNLG5A PSMB9 UGT1A1 MMP10 LOXL2 IL1A SULT2A1 HSD3B1 HOXA4 CXCL10 SLC46A1 THY1 VEGFC ISG20 CXCL9 ENPP3 CSF3 CSF3R SLC5A7 HOXC6 HOXD12 HOXD11 KYNU HOXD10 SLC5A12 HSD17B3 IL1B MT3 SLC17A8 SLC39A5 SLC39A2 PITX2 HOXA6 UGT2B10 SLC6A19 SLC30A8 DHDH SERPINB8 IL6 SLC22A4 SLC22A5 UGT1A5 ADH1A SLC30A10 HEL-S-18 SULT1A1 LRAT HOXC9 NKX2-2 SLC17A1 SULT1A2 CYP3A4 GLYATL3 SLC4A10 IL23A MT1G HS3ST6 IL33 EVX2 ISX TRPV6 SELP HOXD9 SLC26A3 OSM SOCS1 TGFBI STAT3 PMC10740672__F10 Oncogenic signaling pathway plays a crucial role in tumor suppression in vivo ATM MDM2 ATR PMC12220104__F2 Activation of the IL-11 autocrine loop: TGFB acts on the TGFB receptor on the cell membrane, phosphorylating Smad2/3 in the cytoplasm CXCL1 CXCL5 SMAD2 ATF2 GSK3B CCL20 CXCL6 IL11RA MTOR STAT3 PMC3820452__F4 Working model for the proliferative, prosurvival, and migratory roles of TRPM8 in pancreatic adenocarcinoma cells EGF EGFR CAD TRPM8 PMC3820452__F2 Working model for the signaling mechanisms that mediate the cellular functions of TRPM7 in pancreatic adenocarcinoma EGF SOCS3 EGFR HEL164 TRPM7 STAT3 PMC2838317__F8 Differences between TRAIL- and AD5-10-induced signaling pathways FADD PMC12003952__F1 PLEVPs hydrogel alleviates psoriasis by modulating the IL-17 signaling pathway PDC FOXP3 PMC4251736__F4 Disorders of the PI3K-AKT-PTEN pathway PIK3R1 PIK3CA PTEN AKT3 PIK3R2 PMC9320947__F1 Contemporary Concise Review 2021: Interstitial lung disease MMP7 ACTA2 COL1A1 NOTCH3 PMC2832838__F1 CONVERTING HUMAN PLURIPOTENT STEM CELLS INTO BETA CELLS: RECENT ADVANCES AND FUTURE CHALLENGES PDX1 PTF1A EGF HNF4A NODAL CXCR4 SOX17 SOX9 MAFA FOXA2 PMC7716236__F3 Metabolic variations in the course of NB4 differentiation along the myeloid lineage after treatment with ATRA CTRL DAP HEL-S-87p NDUFB6 PGAM1 HEL-S-133P SDHA HEL-S-281 HEL-S-162eP PMC10532319__F7 Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS–Mediated Signaling in Colorectal Cancer Cell Lines CASP3 CCNA2 CDK2 CASP9 PMC7166192__F3 Process of ferroptosis GPX4 AIFM2 LPCAT3 FACL4 TFRC SLC40A1 SLC11A2 PMC11481463__F1 Critical role of IET as a drug precursor and the metabolic pathways relating to IET biosynthesis in S ADH5 tal-1 PMC8039950__F3 Function and underlying mechanisms of sialylated IgG (s-IgG) in myeloid and B cells TLR8 TLR7 TLR9 BCR CD22 IL33 CD40 CD80 CSF1 ELL PMC6977602__F5 FSS regulating osteoclasts bone resorption function via ERK5 signaling pathway (green arrows are positively adjusted; red arrows are negatively adjusted; red lines are decreased due to inhibition of upstream proteins) CTSK NFATC1 MMP9 PMC3181038__F1 Signaling the unfolded protein response: Three proximal sensors IRE1, PERK, and ATF6 regulate the UPR through their respective signaling cascades ATF4 XBP1 PMC8124588__F1 Anaphylaxis: Focus on Transcription Factor Activity KIT MRGPRX2 TFEB TSLP GATA3 STAT3 GATA2 GATA1 PMC6628023__F5 Schematic illustration of the molecular pathway of AhR and its effects on FSHR and survival AHR FSHR PMC2766922__F2 Signaling pathways downstream of HVEM, LIGHT, and their binding partners are shown BCR CD160 TRAF3 GRB2 BTLA TRAF2 PMC3185585__F1 Remodeling the cellular secretory pathway to support enterovirus replication ARF1 ART1 GBF1 PMC3057180__F1 Backup DNA repair pathway SSB BRCA1 POLM PMC2840158__F6 Schematic showing cytoplasmic signaling pathway from ATM to TSC2 via LKB1 and AMPK to repress mTORC1 and induce autophagy TSC2 ATM MTOR PMC3431500__F1 Class I PI3K signal transduction pathway TSC2 TSC1 PTEN RHEB PMC4369255__F1 Synthesis and mechanisms of gaseous neurotransmitters in the relaxation of penile or other vascular tissues RHO PMC3414739__F2 LECA Rabs and their proposed functions RAB21 RAB28 RAB14 RAB23 RAB32 RAB24 PMC7652848__F2 Aryl hydrocarbon receptor (AhR) signaling pathway and tryptophan-indoleamine 2,3-dioxygenase (IDO)-AhR axis AIP AHR PMC4130149__F1 An integrative overview of intracellular signaling pathways by the IL-1R, TLRs, NLRs, and CLRs upon an innate immune response to microbial infection or cell death NLRP3 IL16 TLR4 SYK MYD88 RIPK2 PMC4130149__F4 Schematic overview of TNF-Alpha-induced signaling pathways to activation of NFKB (a), apoptosis (b), and necroptosis (c) RIPK1 TRADD RIPK3 FADD MLKL PMC5316486__F3 Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms PIK3R1 ILKAP CSNK1D HEL2 HEL-S-1 SMAD2 GSK3B SMAD4 PPP2R1A PTEN LATS1 PDPK1 BMPR2 ACVR2A CSNK1A1 AXIN2 SKI TCF3 YAP1 APC LRP5 CD44 LRP6 RAC1 RRAS2 ITGB1 PIK3C2B YWHAQ CREBBP EP300 NEDD9 BMPR1A ITGA6 ACVR1B GRB2 RAF1 HEL-S-93 PMC2933269__F1 Activin signaling regulates transcription of the FSHB gene SMAD4 FSHB PMC7679954__F1 Signaling pathway of NOD1/2 and most TLRs are interconnected through complex pathways NOD1 JUN NOD2 PMC3057180__F2 Exploiting synthetic lethal interactions for the treatment of human cancer ATM GIP ATR PMC2798273__F1 Role of CobT in the late steps of AdoCbl biosynthesis APP NDP PMC5527962__F4 Cell adhesion pathway and ECM–receptor interaction pathways are affected by RCT CD47 CD99 NPNT ESAM CD44 CHAD JAM2 CD36 PMC4334071__F2 Insulin signaling in ovarian thecal cells and proposed mechanisms for selective insulin resistance GRB2 SHE CYP11A1 RAF1 MTOR PMC5527962__F5 Leukocyte transendothelial migration pathway is affected by RCT ITGAM VASP CD99 VCAM1 CXCR4 TEC JAM3 ARHA ITGA4 JAM2 THY1 PMC1869627__F2 Pathway diagram developed using the Ingenuity Pathways Analysis and Knowledge Base in which all genes changed by more than 1.5 fold were queried HEL70 ADAMTS3 CAPN3 CAST GFAP HEL-S-101 AHNAK RDX S100B TTN S100A6 TNC S100A8 PMC3060494__F6 RPA/9-1-1- and hMSH2-mediated ATR activation in DNA damage signaling TOPBP1 ATRIP MSH6 MSH2 ATR PMC5880504__F8 Proposed pathway regulating cultured primary mouse hepatocyte levels of ECs: impact of phytocannabinoids (Δ9-THC), 2-AG, and Fabp1 gene ablation ALB FAAH FABP1 PMC4728196__F1 PI3K pathway with respective PI3K inhibitors TSC2 BAD MDM2 PTEN MTOR PMC6831867__F1 Reactive oxygen species (ROS) metabolism NOX3 DUOX1 DUOX2 NOX4 HEL-S-44 NOX5 PMC6831867__F2 Metabolic interplay between various ROS generators NOX4 HEL-S-44 PMC4264123__F1 Hypothetical diagram of LPS-triggered inflammation and apoptosis pathways summarized in A TBK1 HEL-S-62p CD14 IRF7 TRAF3 LBP TRAF6 IRF3 MYD88 FADD PMC5220130__F7 Schematic representation of the BCR signaling pathway demonstrating the ibrutinib sensitivity of BTK C481 variants and their impact on downstream signaling BCR SRC PLCG2 PMC3714559__F1 Model for resolving transcription-blocking lesions XPA UVSSA PMC6549003__F6 Proposed model for an auto-regulatory feedback loop between the miR-17-92 cluster and the Wnt/Beta-catenin/LEF1 signaling pathway LEF1 APC FZD4 FRZB PMC3310826__F16 Schematic showing alterations to the TAG biosynthesis pathway in AS11 when DGAT1 activity is absent DGAT1 PC LPA LPCAT2 PMC9340544__F5 Heme Biosynthetic Gene Expression Analysis With dPCR in Erythropoietic Protoporphyria Patients ALAS1 FECH UROD UROS HMBS CPOX ALAS2 PMC8452481__F3 The nervous system in pancreatic cancer ASAP1 ALK HSP90AB1 EGFR MYC TNK2 RB1 MTOR MMP7 RRM1 NGFR RRM2 SRC CDH2 ROS1 NTRK2 MMP9 CD44 NTRK3 PARP1 HEL-S-125m NFKBIA RET ERBB2 KLF4 GNAS CP STAT3 PMC3194983__F1 Inhibition of the type I interferon (IFN) induction and signaling pathways by viral proteins of KSHV TBK1 STAT1 TLR4 KY STAT2 TYK2 IFNAR2 JAK1 IFNAR1 TLR3 MX1 PMC3712028__F7 Model for the mechanism of regulation of glucose metabolism in muscle and liver by leptin in the VMH POMC ARC STAT3 PMC11593954__F5 Comparison of neuro-regeneration mechanisms in the peripheral and central nervous systems CNTF SHH RHO CDH2 MTOR BDNF PMC11661762__F2 Key enzymes of glucose metabolism (gluconeogenesis, green arrows), DNL (blue arrows), and FAO (orange arrows) are activated by TH (in red) PDK4 UCP2 FASN HEL-S-5 PMC4544784__F5 MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis EPOR TH CD14 CD9 EPO CD33 CD6 CD34 CD44 TPO TNF CD2 CD7 CD22 ELL CD19 CD36 CD24 PMC3906548__F1 AT2R-mediated molecular pathways involved in tissue injury BDNF PMC3771549__F1 Role of Nox-derived ROS in Ang II-mediated effects in vascular cells ARHA PMC10138623__F6 TLR4–RAGE crosstalk participates in the HG-enhanced LPS-induced inflammation in BAMs (created with BioRender HMGB1 TLR4 S100A8 MYD88 PMC6562791__F1 Interconnected pathways of non-essential amino acids (NEAA) metabolism BCAT1 PSAT1 SHMT1 ASNS PRODH PSPH HEL-S-51e PAH ASS1 PHGDH ASL GLS PMC8964769__F6 Publisher Correction: Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway ANGPT2 SMAD4 ENG SMAD1 HMFT1766 DKFZp781O1323 STAT3 PMC9248037__F3 Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer HNF4A GSK3B SULT1E1 PMC9098828__F1 Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism PCSK9 LDLR HMGCR PMC4161047__F1 Pathways implicated in type I IFN production following L CGAS NOD1 DDX41 IRF3 NOD2 MAVS PMC2267731__F2 BL module: A network visualization of the top 25 scoring genes in BL MYB TANK POU2F1 BAX PMC4617137__F1 Anabolic pathway of renal sulfatides ELOVL6 ELOVL1 ELOVL4 UGCG ELOVL5 ELOVL3 ELOVL7 FA2H CERS3 LASS1 CERS5 ELOVL2 SMS CERS2 CERS6 PMC8733402__F1 Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases IGF1 FOXO3A INS PTEN MTOR INSR PMC7568723__F6 Histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis LIMK2 VAV3 ROCK1 PFN2 RHO PMC9167587__F6 Proposed pathway of quercetin in preventing CKD SMAD2 SMAD4 PMC9678516__F9 Exploring the mechanism of Tengli Kangliu Decoction in the prevention and treatment of colorectal cancer precancerous based on network pharmacology CHUK CCNA2 MPO RUNX2 PGR ACACA EGFR MYC BCL2L1 RHO CCL2 CHEK2 PLAT E2F2 F2 PTPN1 F3 CRP NOS2 IRF-1 JUN HK2 SELE BAX CTSO FOS IGF2 NR3C1 NR3C2 TNF HPSE IKBKB APOB EDNRA PRKCB CYP3A4 CDK2 RELA NR1C2 BCL2 PPARG CYCS PMC8021797__F2 Schematic presentation of the STAT1 signaling pathway STAT1 STAT2 IFNGR2 TYK2 IFNAR2 IFNAR1 IFNGR1 STAT3 PMC6571146__F8 Model depicting the potential involvement of the Mek/ERK1/2-MAPK and the PI3K/Akt/mTOR signaling pathways at different stages of developmental myelination and during adulthood TSC2 TSC1 MTOR RHEB PMC8347825__F2 Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment XPC ERCC1 MSH2 BRCA1 PMS2 PMC8542838__F3 An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities TBK1 OTUB2 CGAS IRF7 USP20 IRF3 IFNAR2 USP49 OTUD3 USP18 CYLD TYK2 USP44 OTUD4 USP22 MAVS PMC6787451__F6 Effects of ASA in SK‐N‐SH (N) cells TH CDK2 PRB1 CDK4 PMC3392816__F5 Model for inhibitory effect of extracellular nicotinamide phosphoribosyltransferase on insulin-like growth factor-1 function in chondrocytes IGF1R IGF1 IRS1 PMC8380002__F6 Glucose metabolic crosstalk and regulation in brain function and diseases TSC2 TSC1 WNT3A GSK3B LRP6 HIF1A RHEB PMC7072213__F2 Biogenesis mechanism of (a) exosomes and (b) MV, and their release processes which are coordinated through two different intracellular pathways, such as exosomes generation pathway and lysosomal degradation pathway RAB35 SDCBP RAB27A RAB27B PMC8532910__F1 Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications TRADD CYLD TNF FADD MLKL PMC8558079__F7 Signal Transduction and Molecular Regulation in Fatty Liver Disease AMOT NF2 VGLL4 ARHA LATS1 MOB1A PMC9684170__F3 Hypersensitivity reactions to small molecule drugs HEL-S-62p MRGPRX2 C9 CS C4B_2 C7 C6 C1S STAT3 PMC7352703__F4 Enrichment Kyoto Encyclopaedia of Genes and Genomes (KEGG) analysis of DEGs engaged in the Notch signaling pathway HES5 NUMB CREBBP ATXN1 EP300 ATXN1L HES1 PMC9498168__F6A MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway PDE1C PIM2 GRIK3 DUSP19 MYOM2 SOX4 MTBP UPK1A HEL32 EPM2A SPINK7 NHS ZNF99 ABCC9 ERMN DYNAP SLC9A4 TXLNB ERP27 FBN3 ABHD1 TMEM74 CLEC3A SLITRK3 KCNN3 SMLR1 AKAP12 IL1A ATP2B4 SYT14 MPP7 FOS MZT1 MYEF2 MAPK10 PI15 GPR19 HEL110 GRIA2 RAG2 TIAM1 PLN CLSPN E2F7 GRID2 GINS4 MC2R KLF2 IL2RA SYNM MGA PIG59 CASR RIPK2 RGMB CCDC17 BYSL CADM2 DSG3 SFRP1 CADPS HEL-S-117 SDR9C7 RBL1 MAL SOX2 RGS4 ABCG5 SCN8A DMP1 SIX4 NR4A3 SOX6 PMC3856587__F2 Genetic pathway predicted to regulate the interaction between 5-HT synthesis, transport and degradation and the stress response mediated by the HPA axis CRH BDNF PMC10935043__F7 Diagram picturing two alternative pathways of sorting damaged mitochondrial components into mitochondrial-derived vesicles PINK1 PARK2 SNX9 PMC4474670__F3 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity EGF CHMP6 VPS25 EHD2 EHD3 LDLR ARHA CHMP3 VPS28 ARF6 VPS36 CDC42 PMC3856587__F3 Simplified model of the regulatory interactions between the serotonin and stress response pathways mediated by the HPA axis SLC18A2 CRH AVP MAOA BDNF PMC3087601__F1 Cellular and bacterial profiles associated with oral epithelium-microbiota interactions ATM CDC6 CDK2 MDM2 SMAD4 ATR CDK7 PCNA CDC45 SKP2 MYT1 PMC8855827__F5 Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach PTK6 HGF SOCS3 STAT2 NTRK1 EGFR MAPK3 NFKBIZ STAP2 STAT5B STAT4 MAPK1 JAK1 HTR2A STAT3 PMC4474670__F6 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity RHO SP1 CAD LAT RGS14 PMC4474670__F7 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity DIS3L MT3 CNOT4 CNOT2 CA14 CCR4 DIS3 LSM1 LSM3 EDC3 PAN2 EDC4 LSM8 PAN3 RQCD1 DCPS XRN1 CNOT3 LSM4 LSM2 PMC5994424__F8 ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 EGF LAMTOR1 VEGFA IL4 ARG1 ADM PMC7510352__F1 Families of PDGF/PDGFR and the downstream signalling pathways PDGFD BAD PDGFC MMP2 MYC GRB2 VEGFA BCL2L1 SMAD1 STAT3 PMC4488003__F6 The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core MTOR BAX PMC8651070__F2 Mechanisms Regulating HLA Class-I Antigen Processing Machinery Component Expression in Cancer Cells TBK1 STAT1 CGAS TRAF5 IRF7 TRAF3 LTB IRF3 JAK1 TRAF2 IRF-1 NBR1 PMC5983187__F4 Intracellular signaling pathways arising from B common (Bc) receptor activation AK2 LYN JAK1 PMC10796104__F1 Mechanisms of Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) in chronic pain SOCS3 IL33 CCL2 STAT3 PMC8684694__F7 Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway IL6 GLA STAT3 PMC7649190__F2 Hypothesis that vascular endothelial growth factor (VEGF) may promote T cell exhaustion and therefore Demodex proliferation, by analogy with what happens with tumors LAG3 TSLP PMC7202399__F2 FOXO1 protein activation GPX3 PTGER4 NOX4 FOXO1 PMC8122057__F4 Interleukin (IL)-4 signaling sources (A) and targets (B) AID GATA3 PMC3797768__F4 An Integrated Approach Based on Multiplexed Protein Array and iTRAQ Labeling for In-Depth Identification of Pathways Associated to IVF Outcome FGA TH HRG HAMP PLG HEL-S-92n MBL2 CRP LBP SERPING1 IL4 APOH TF PMC7865468__F1 TGFB in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment HEL-S-26 SLC27A2 GCLC FBP1 SMAD2 GRB2 ARHA MTOR HEL-S-133P PMC2880454__F1 Targeting the cancer kinome through polypharmacology EGFR INSR PMC6219450__F3 DSB-free recombination-dependent replication.A BRCA2 RAD52 RAD51 MRE11A WRN DNA2 PMC8979166__F2 Why Does Piscirickettsia salmonis Break the Immunological Paradigm in Farmed Salmon? Biological Context to Understand the Relative Control of Piscirickettsiosis CXCR1 C9 CD37 APC STAT4 CD22 CD200 PMC9315303__F7 Genistein promotes M1 macrophage apoptosis and reduces inflammatory response by disrupting miR-21/TIPE2 pathway TLR4 MYD88 VMP1 PMC5408670__F1 Tumor necrosis factorA (TNF)/TNF receptor (TNFR)-mediated cell signaling TRADD TNF TRAF2 FADD PMC1502453__F5 Hoxc8-regulated transcriptional network in vivo EGF CDH11 HOXC8 EGFR SMAD6 CD44 SMAD4 SMAD1 PMC9031059__F3 Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity MRC1 NAB2 GGA1 RCN2 MED13 PMC11846535__F4 Diagrammatic summary of therapeutic strategies and agents (light purple) targeting the TGFB signaling pathway SMAD2 SMAD4 PMC10443056__F1 Different interventions enhance nerve regeneration for the treatment of AD NGF MSC ACHE BDNF PMC2649302__F2 Wnt/-catenin signaling pathway APC GSK3B LRP6 PMC2649302__F3 Conversations between Wnt/Beta-catenin and MAPK signaling pathways APC GSK3B LRP6 ARHA RAC1 RAF1 CDC42 PMC3586749__F4 Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma EGF DSG2 SMAD2 MMP9 EGFR PMC2809778__F2 Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, Parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis PINK1 POLG POLRMT HTRA2 TFAM PMC9454636__F1 Drosophila as a Model for Human Viral Neuroinfections TBK1 CGAS RELN TRADD IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TRAF2 FADD TAB3 PMC11846535__F1 This figure illustrates Canonical (SMAD dependent) and Non-canonical (SMAD independent) TGFB signaling pathways SMAD2 TGFBR1 TGFBR2 RHO MTOR PMC9454636__F2 Drosophila as a Model for Human Viral Neuroinfections AGO2 IRF7 IRF3 PMC11846535__F2 Exploring TGFB Signaling in Cancer Progression: Prospects and Therapeutic Strategies EGF HGF APC PTCH1 SMO MTOR PMC6707713__F4 Interplay between DNA tumor viruses and the host DNA damage response RNF168 ATM H2AX BRCA1 PMC8136133__F11 Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer HEL-S-7a KCNMB3 KCNMB4 PDE6G CS PDE5A GUCY1A2 MAPK14 PDE11A POU2F1 GNAL NOS2 NPPA NPR2 GIPR NPPC PDE1A MTNR1B ADCY5 GNAS GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F PMC3924201__F4 Two mechanisms for growth-factor-mediated regulation of the Hippo pathway: activation of Ras-MAPK signaling and activation of PI3K-PDK1 signaling EGF AJUBA LPA PMC3924201__F1 Control of the core Hippo signaling pathway through interacting upstream modules PATJ WTIP AMOT NF2 AREG SCRIB LATS1 LATS2 PMC3924201__F2 Hippo pathway-mediated regulation of cell lineage and pluripotency by adhesion and epithelial polarization in the early mouse embryo CDX2 AMOT NF2 LATS1 LATS2 PMC6481737__F9 Working model of stiffness-dependent calcium response for neutrophils on HUVECs CD44 SRC SYK PMC9450835__F10 Summary illustration of the phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair VAPA PI4K2A OSBP PMC7449905__F4 PAK1 is a key molecular determinant in major cell proliferation pathways EGF PAK1 LEF1 EGFR MYC RAC1 MTOR JUN PMC7449905__F7 PAK1 in autophagy pathways ULK1 PAK1 ATG12 FOXO3A SQSTM1 ATG101 MTOR DKFZp686F0183 PMC7449905__F9 Crosstalk between PAK1 and other cancer-related pathways TEAD3 PAK1 TEAD4 MTOR TEAD2 PMC6616108__F1 Processing of CD8 ppCT T-cell epitopes TAP2 B2M PMC8356873__F1 Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma MAF KEAP1 NQO1 PMC10310781__F1 Amyloid Beta-based therapy for Alzheimer’s disease: challenges, successes and future BACE1 BACE2 APP PMC3858858__F4 Overall PI3K and MAPK-Erk signaling is complex, but can highly influence the balance between cell survival and death BAD PTEN MTOR BAX PMC3690105__F1 Metabolic pathway of clopidogrel CYP2B6 CYP2C9 CYP2C19 PMC8989865__F7 TGFB activates NLRP3 inflammasome by an autocrine production of TGFB in LX-2 human hepatic stellate cells NLRP3 IL18 NOX4 PMC3837249__F1 Toll-like receptor signaling in liver cells TLR9 IRF7 IRAK1 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP MAL PMC11012292__F1 Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet HEL-S-61p ChAT ACHE PEMT PMC2678983__F4 IFN-gamma signaling pathway STAT1 DAO IRF9 ATF2 PMC10383978__F3 Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer ME1 ME2 PC PMC7168569__F1 Regulatory roles and underlying mechanisms of ELA-APJ axis in heart failure MMP9 TGFB1 GATA4 BAX PMC4568774__F1 Anti-tumor mechanism of combi-targeting molecule EGF BAD EGFR ERCC1 RAF1 TGFA BAX PMC7990776__F2 BRD4 in innate immunity HMGB1 TBK1 CGAS CHUK IKBKG MITA IRF3 IL6 MYD88 TNF TLR1 TLR3 GSDMD IKBKB NLRP3 NFKBIA IL18 RELA CDK9 IL1B CASP5 CASP4 BRD4 PMC4875828__F1 Mechanobiology of TGFB Signaling in the Skeleton RUNX2 SMAD2 ARHA SMAD1 DKFZp781O1323 SOX9 PMC5260935__F7 Late-phase synthesis of IKBA insulates the TLR4-activated canonical NFKB pathway from noncanonical NFKB signaling in macrophages NFKBIA TLR4 RELA PMC8584326__F1 Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering BAK1 BIN2 PMC9370360__F4 Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases ELF2 EIF2A APP PMC6533689__F2 Telomerase regulation and telomere elongation pathway TEP1 TERT STAT3 POLI PMC3882437__F4 Perturbed pattern of genes in the peroxisome proliferation activator receptor (PPAR) signaling pathway by DEX administration (ethanol plus DEX vs UBC ME1 UCP1 HEL-S-28 LPL CPT2 PMC4055569__F8 Augmenting Microarray Data with Literature-Based Knowledge to Enhance Gene Regulatory Network Inference EGF FOXN3 PTEN TNF MTOR CRK BCL6 ATM CDK2 BIK CCNG1 MDM2 TP73 JUN PCNA STAT3 FASN BAX PMC6906806__F10 The summary of the signaling pathway of TRPC3 upregulation in fibroblasts involved in fibrosis SMAD2 ARHA TRPC3 PMC10843903__F6 Increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study TSC2 BAD BCR EBP SYK PTEN EIF4E RBL2 CD19 PMC10525672__F3 Stress Urinary Incontinence: An Unsolved Clinical Challenge SMAD2 TGFBR1 SMAD4 PMC8533529__F2 Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution NAMPT NNMT SARM1 PMC7698658__F5 Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds FOXM1 AREG BIRC5 CENPF EZR CENPE KIN IL6 AURKB CDC45 IL16 TLR7 BUB1B TRAF2 CCL3 PMC3942883__F1 Induction and clearance strategies TEF PTEN PMC9066095__F3 New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials WNT3A PMC4591923__F1 Peptide vaccines and peptidomimetics targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy KDR EGFR GRB2 VEGFA MTOR TGFA PMC4231819__F1 Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential CD14 TRAF6 IRF3 MYD88 IL1B PMC6928879__F1 AHR-dependent signaling pathways AHR EGFR PMC6299603__F2 Adipocytokines mediate pancreatic cancer tumorigenesis by different signaling mechanisms HEY2 MTOR SIRT1 STAT3 PMC10957538__F1 Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms NLRP3 IL6 MUC5B IL1B PMC6299603__F3 Altered gut microbiota is responsible for pancreatic cancer progression CD14 MYD88 MTOR PMC9290708__F1 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis CYP27A1 CYP8B1 FGF19 FGFR4 CYP7A1 CYP27B1 PMC5359376__F5 Enrichment analysis for pathway map ontologies revealed significant biological processes associated with the most promising targets commonly deregulated in mouse and human ALS EGF ELL PMC6700737__F1 MiR-126-orchestrated regulation of pDC effector functions in lymph nodes undergoing an immune response TSC2 PDC TSC1 TLR9 IRF7 MYD88 MTOR PMC9290708__F3 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis FGF19 FGFR4 CYP7A1 PMC7963413__F2 Cascade of events triggered by the overexpression of RB1CC1 in SCZ pathogenesis TSC2 TSC1 RB1CC1 PMC12086142__F1 Regulatory mechanisms of NLRP3 inflammasome in PF NLRP3 PINK1 SMAD2 SMAD4 MYD88 TGFB1 TGFBI GSDMD PMC2990064__F4 Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation BCL2 BAX PMC4322985__F1 BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications EGF EGFR PTEN PMC2891968__F5 Cellular pathways leading to upregulation of COX-2 in neutrophils CD14 TLR4 LBP PMC4850258__F5 Regulatory interactions of Usv101 CIRSR UXS1 GPR4 SP1 PMC2093951__F9 NOVEL VIP SIGNALING PATHWAY IN T CELLS cAMP→ Protein Tyrosine Phosphatase (SHP-2?)→JAK2/STAT4→Th1 differentiation TYK2 IL12RB1 VIP PMC6297758__F7 Involvement of c-myb and E2F1 in the expression and amplification of MYCN GMNN L3MBTL1 PMC6342007__F2 Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases TBK1 RIPK1 TRADD CYLD RIPK3 PELI1 OPTN FADD TAB3 PMC10957538__F2 Epithelial plasticity and impact of particulate matter (PM): Exposure to PM in short term, leads to inhibition of Notch1 by stimulating STAT3 and aryl hydrocarbon receptor (AhR) activation in basal epithelial cells AHR ZEB2 SACS SCGB1A1 CDH2 STAT3 BRD4 PMC10957538__F3 Impact of particulate matter (PM) on airway remodelling CXCL1 CXCL8 IL5 PMC8386127__F11 TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage IL10 TLR4 LPL DAP ADAM10 MYD88 AXL PMC3728834__F7 Proposed model illustrating the effects of reduced TH in thyroid cancer development in ThrbPV/PV-PTU mice GSK3B PTEN NR1A2 PMC6478618__F2 Nonalcoholic fatty liver disease-Kyoto Encyclopedia of Genes and Genomes pathway and mechanisms of disease pathogenesis SOCS3 EBP INS RAC1 UNKL XBP1 IRS1 INSR LEP ATF4 TRAF2 ITCH BAX PMC5713364__F7 Analysis of the interconnection between AKAP12 and the merged networks of related joint diseases and functions ADAMTS2 RENBP PMC6602343__F1 Developmental signaling pathway architectures sense, process and control ligands in space and time EGF GSK3B SMO TF PMC5039030__F8 Model - DPP9 is a negative regulator for Syk signalling, targeting active Syk for degradation by the N-end rule pathway BCR FLNA SYK DPP9 CBL PMC4797178__F5 GeneGO pathway map “Development_TGF-beta-dependent induction of EMT via SMADs” is significantly enriched for genes differentially expressed between MCF-7-Snail and MCF-7-Control cells HMGA2 GIG8 HGF HEL-S-28 SMAD2 SMAD4 ARHA CDH2 SP1 PMC2978223__F1 Daphnia pulex insulin and TOR signalling pathways, adapted from Drosophila melanogaster TSC2 TSC1 PTEN PMC4905267__F1 Common vesicular trafficking module in the assembly of the immune synapse and the primary cilium VAMP3 APC SMO IFT20 PMC11204038__F1 Schematic diagram showing the NAD+ metabolic pathway NAMPT NMRK2 NNMT CYP2E1 SIRT1 NMRK1 PMC4117641__F5 TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in ABeta-Expressing Caenorhabditis elegans TCP1 CCT8 STK24 PS1TP5BP1 MOB4 PMC11850097__F11 Action of ZIP8 in macrophage polarisation and IDD ADAMTS5 TGFA PMC7226805__F1 Molecular mechanisms regulating autophagy ULK1 ATG12 VPS18 ATG101 ATG14 PMC4874035__F7 Vascular control of the haematopoietic microenvironment by Slit/Robo signalling CDC42 PMC11241496__F2 Targeted therapies in RAS-RAF-MAPK pathway RET EGFR PTEN MTOR PMC11241496__F3 Targeted therapies in the vascular endothelial growth factor (VEGF) pathway PIGF VEGFC VEGFA PTEN MTOR AXL VEGFB PMC5962337__F7 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress AS3MT MTF1 AQP7 AQP9 HEL-S-162eP PMC5713364__F6 Network analysis by Ingenuity®Pathway Analysis (IPA) indicated molecules associated with rheumatic disease and inflammation of joint NOTCH2 AKAP12 GPC1 ADAMTS12 RGS5 SESN3 PLG KCTD20 BDKRB1 KLKB1 PPARG CREB5 PMC5512440__F7 Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis LDLR ABCA1 CD36 PMC3575813__F10 Presence of a diversity of Alu-mediated events in genes involved in apoptosis BAD TRADD ATM MYD88 TRAF2 FADD PMC7933466__F1 Metabolites regulating nucleic acid sensing pathways TBK1 KEAP1 SUCNR1 IRF3 TLR3 MAVS PMC7819868__F1 REG4 signaling pathway CDX2 REG4 EGFR GSK3B CDK4 SP1 TGFA ADAM17 CDK6 GPR37 PMC8079368__F4 Molecular mechanism of lateral bud differentiation of Pinus massoniana based on high-throughput sequencing HEL-S-30 BIN2 TF PMC4915362__F3 Converging roles of caspases in inflammasome activation, cell death and innate immunity NLRP3 RIPK1 CARD9 BCL10 RIPK3 SYK MYD88 TNF IL1B FADD NOD2 PMC9468863__F2 Impact of local anesthetics on epigenetics in cancer EGFR BTG1 PTEN MTOR SOX4 PMC4915362__F4 Converging roles of caspases in inflammasome activation, cell death and innate immunity TBK1 CGAS RIPK3 IRF3 NLRP3 RIPK1 APAF1 CYLD IL1B FADD MLKL MAVS BAX PMC10900617__F8 ZnONPs disrupt lysosome activity and impair autophagic flux to facilitate exosome secretion in keratinocytes and macrophages NLRP3 TLR1 TLR3 PMC7468567__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 VASP FOS HEL-S-99n HEL-S-15 BCL2L1 WAS CCL2 MAP3K13 RAB7A TNF PFN1 RAG2 HLA-B HLA-C HLA-A IL2RG SNX2 JUN PXN CAPZB CDC42 PMC8430223__F2 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases RUNX2 POSTN LRP6 CTLA4 EPHB4 PMC8996945__F2 Prognostic Role and Significance of Dll4 and Toll-like Receptors in Cancer Development JAG2 PMC6509750__F3 Influence of TGFB1 on the balance between the canonical WNT/Beta-catenin signaling and PPARG APC LRP5 LRP6 PTEN DKK1 PMC8430223__F3 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases ATF4 POSTN EIF2A PMC8430223__F4 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases MMP3 ADAMTS4 POSTN NOS2 MTOR PMC8430223__F5 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases NLRP3 POSTN TNF IL1B PMC5962337__F1 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress ATP7B SCO2 COX17 SCO1 ATP7A ATOX1 COX19 COX11 CP CCS CPO PMC7587925__F3 Kupffer Cells CD14 TLR4 LBP TRAF6 MYD88 TNF PMC3606533__F1 Genes in choline/1-carbon metabolism and related pathways influence hepatic lipid balance HEL-S-61p PNPLA3 ABCB4 SLC44A1 APC CHDH PEMT PMC11011430__F5 Signaling pathways upregulated in higher Gleason grade groups NUP205 POM121 NUP188 WAPAL SMAD4 NUP62 SENP2 MAGOH DBF4 THOC7 MTBP SAP18 THOC6 NUP133 MDM2 NUP54 NUP85 EIF4A3 RNPS1 NIPBL NDC1 RAD21 NUP155 THOC2 TICRR MAL MAU2 NUP214 NMD3 STAG1 CDC45 STAG2 SMC3 CDK2 RAN PHAX PCNA SKP2 TRIP13 PMC11011430__F6 Analysis of the Gene Networks and Pathways Correlated with Tissue Differentiation in Prostate Cancer PLN NOG PI3 BCR DAO CAV3 HRC MCU TRDN PMC3262916__F2 Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment NR1i1 APC PMC11204910__F1 Heme biosynthetic pathway in erythroid cells and the role of ATP-binding cassette transporter B7 (ABCB7 gene): The first enzyme of heme synthesis is 5-aminolevulinate synthase (ALAS2), which is the rate-limiting enzyme NDUFB11 ABCB7 SLC25A37 FES ALAS2 HSCB PMC7923230__F6 New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes UNC45B ITGB3 CELA1 SLC5A1 CRABP2 SGCE NOX4 THY1 FST IDO1 VLDLR LIPG COL1A2 TXNIP SERPINB2 PMC7923230__F2 ‘Signaling pathways regulating pluripotency of stem cells’ KEGG pathway SOX2 NODAL DUSP9 LIF APC SMAD4 ISL1 BMP4 HES1 NOG REST JUN STAT3 PMC3984709__F9 Schematic diagram of the proposed interface between mechanostimulation and biological signaling at acupoint PANX1 TRPV1 PMC9681895__F3 Effect of maternal body mass index on the steroid profile in women with gestational diabetes mellitus CYP11A1 CYP17A1 PMC9172006__F3 TMEM16A as a potential treatment target for head and neck cancer EGF EGFR SRC STAT3 PMC8590447__F12 SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein ACE2 NOTCH3 PMC4721683__F4 Signaling pathways related to the activity of oxaliplatin and 5-FU for colon cancer cell lines NF1 SMAD2 APC EGFR TGFBR1 GSK3B AXIN1 SMAD4 JAK3 MTOR PMC2556095__F6 In the canonical TGFB signalling pathway, ligands signal through type I and II transmembrane protein kinase receptors SMAD2 SMAD4 OVOL1 TGFB1 TF IRF6 PMC2556095__F4 TGFBeta-related signalling pathway controlling Myc activity in keratinocytes E2F4 MYC OVOL1 PMC9661392__F8 Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway TMEM100 SCNN1D CCND1 CDH2 BAX PMC6700476__F1 Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells SOX2 TBXT MIXL1 MTOR BMP4 PMC11074473__F3 M5C methylation in innate immunity (By figdraw CGAS TLR5 GPX4 TLR9 IRF7 IRF3 NSUN5 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 ACE2 NSUN2 MAVS PMC10813482__F1 DNA modification of MSCs in SONFH RUNX2 MSC FZD1 ABCB1 PMC4885164__F1 Role of stromal cell-derived factor 1A pathway in bone metastatic prostate cancer CXCL16 CXCR4 MSC CD164 PMC6076887__F3 MRN complex activates possible (alternative) pathways at DSBs RAD17 ATM TOPBP1 BRCA2 ATRIP MDC1 RAD51 ATR DNA2 BRCA1 PMC4967105__F3 SKN-1 in the development of C POP1 MED1 PMC4652017__F2 Putative stress signaling pathway in wheat where functional genomics contribute MYB ERF TF PMC4460069__F1 Comparative Transcriptome Analysis Reveals the Influence of Abscisic Acid on the Metabolism of Pigments, Ascorbic Acid and Folic Acid during Strawberry Fruit Ripening GGH SHD PMVK DHFR MVK GMPPB DHPS IPP PMC5803081__F1 Beyond Alkylating Agents for Gliomas: Quo Vadimus? HEL-S-26 MYC HK2 PMC9270554__F7 Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria ME1 HEL-S-30 HEL-S-64p HEL-75 HMGCS1 OGDH ACLY HEL-S-87p HEL-S-133P FASN HEL-S-68p PMC6155262__F7 CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1A/VEGF-A pathway in colorectal cancer CCR7 VEGFA CCL19 PMC4122337__F2 Potential roles of GPR120 and its agonists in the management of diabetes NLRP3 MAP3K7IP1 IL1B PMC9616595__F1 Intersection of metabolism and inflammation is governed by the intracellular topology of hexokinases and the metabolic fate of glucose SIRT2 S100A8 S100A9 HK2 HEL-S-162eP PMC8151958__F2 GSK-3B in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions TSC2 IGF1 PMC9293977__F5 Bone remodeling: an operational process ensuring survival and bone mechanical competence MTOR EPHB4 EPHB2 PMC4589110__F4 TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System TXNIP PTEN DTNB PRX MSRA PMC5600869__F3 Passive DNA demethylation pathway DNMT3B PMC5600869__F4 Active DNA demethylation pathway SMUG1 MBD4 TDG DNMT3B PMC11622572__F7 Signaling pathway analysis of genes in cluster 5 using KEGG database (A) Gene expression profile during functional unloading (B) Heatmap of DEGs with p OLR1 SLC27A4 ANGPTL4 PLIN1 APOC3 HMGCS1 CPT2 HEL-S-104 PLIN4 RXRA ACOX1 PLTP ACADL LPL APOA5 FABP5 APOA2 EHHADH FABP1 CD36 PMC5955127__F3 Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells PYGO2 FOXM1 APC GSK3B TCF4 PMC5343833__F6 Involvement of TGFB/Smad pathway in AA-induced fibrogenesis PMC4197574__F3 Studying ultradian oscillations using optogenetic tools ASCL1 CRY2 MTOR PMC4861305__F1 Decorin induces autophagy in endothelial cells DCN MTOR PEG3 PMC4066640__F5 MYC autorepression and general cellular gene repression by histone modification MYC PTEN EZH2 PMC5009385__F7 Insulin-like growth factor 1 regulates growth of endometrial carcinoma through PI3k signaling pathway IGF1R IGF1 IGF2 CCND1 IGF2R PMC7247696__F1 Toll-like-receptor (TLR)-4, after activation by pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) supported by myeloid differentiation factor-2 (MD-2), initiates downstream signaling in two major ways TLR4 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TIRAP PMC7247696__F2 TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives TBK1 DKK3 PMC7828596__F1 Canonical aryl-hydrocarbon receptor (AhR) pathway AIP EPHX1 AHRR AHR PMC5503214__F7 Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat DGAT1 APOB DGAT2 CIDEB PMC11806588__F2 The potential pathways and mechanisms of genes associated with skin colour-related phenotypes SPG7 DEF8 ASIP MC1R IRF4 CPNE7 PMC11806588__F3 The potential pathways and mechanisms of genes associated with wrinkling and sagging-related phenotypes SPTLC1 PRDM16 RORA PMC5600869__F1 Schematic diagram for molecular mechanisms of activation of ER stress PI3 ATF4 EIF2A PMC11806588__F4 The potential pathways and mechanisms of genes associated with skin cancer-related phenotypes CLPTM1L LPP TERT PMC9479192__F1 Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies APC GSK3B PMC3374844__F1 Three major UPR pathways in metazoans ATF4 EIF2A XBP1 PMC9414803__F4 Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet ABCG8 PON1 ABCA1 TG CYP7A1 PMC5470961__F5 Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis BAMBI NLK FER EPX SMAD4 ARHA TNF OTP LMO7 INSR PMC9095829__F10 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases TRPC5 IL8RB TRPC3 ADM PMC3362997__F10 Competitive displacement of DMP1 by ASARM peptide modulates PHEX–DMP1-mediated FGF23 expression (see central osteoblast in green) FGF23 DMP1 TCIRG1 PMC6292929__F1 CBL0137 exhibits its antitumor activity via multiple pathways NOTCH1 HSF1 CBL PMC9214065__F1 Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell INA APC GSK3B LRP5 LRP6 PMC6440987__F2 Pool sizes of intracellular metabolites in S HEL-S-26 PCK1 ENO1 HEL60 HEL-S-32 MDH2 HEL-S-68p PMC9268386__F2 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis STAT1 TANK SENP6 MYC IFNG PMC9268386__F3 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis VEGFA CCL7 MTOR TGFB1 PMC8787094__F1 Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins CGAS RIPK3 IRF3 MYD88 TLR3 ZBP1 GSDMD RNASEL NLRP3 TLR8 OAS1 TLR7 RNASET2 RO60 RNASE2 ZNFX1 MLKL MAVS PMC3230308__F1 Autophagy pathway and relationship to mTOR signaling TSC2 PML TSC1 AMBRA1 PTEN UVRAG MTOR PMC3473259__F2 Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response ENO3 HEL-S-97n GSK3B UBE2G1 AKTIP PFKM HIF1A MTOR FOXO1 CBL HEL-S-162eP NDUFA3 CYGB AAG1 CLN3 CHFR PMC2727910__F1 Map of arachidonic acid (AA) cascade LTA COX1 LTB PMC9686921__F6 NADPH Oxidase 5 (NOX5) Overexpression Promotes Endothelial Dysfunction via Cell Apoptosis, Migration, and Metabolic Alterations in Human Brain Microvascular Endothelial Cells (hCMEC/D3) RPS5 RPL29 RPL28 RPL35 WDR55 RPL19 RPL34 RPS10 PMC6414445__F9 Rickettsia conorii and R ME2 CS SLC25A5 HADHB MTCH2 DLD VDAC3 HEL-S-32 MDH2 SLC25A6 HEL-S-26 SLC25A3 GOT2 FH PDHA1 ACO2 TOMM40 MST065 ACLY SLC25A1 PMC9596445__F5 Phenylpropane Metabolic Pathway Illustrates in flavonoids accumulation and lignin synthesis in Populus wilsonii F3 CAD PRX PMC9450349__F5 ASXL1/2 mutations and myeloid malignancies MTOR BAP1 BRD4 PMC7324642__F2 Humoral innate immune signaling pathways SPN REL FADD PMC2330230__F9 Candidate interactors and their putative postion in the Frizzled signaling pathway APC EGFR CREB1 ARHA NOTO HDAC1 PMC12235022__F6 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation DEFB4B P2RY11 EPO SOCS3 TLR9 KEAP1 MAPK8 MAPK3 MYC GSK3B MAPK14 HSPD1 CCL2 IFNG MMP3 MFN2 POMC NR1i1 GHR CASP9 NOS2 APOE ACTR2 SNCA ANGPT2 CASP12 SST APC IRF3 FZD4 TNF TSLP PRKACG THPO HLA-B TSC2 LEP EDNRA CNR2 EDNRB IGF1 CD27 CDKN1A CRH AVP CCL20 BCL2 IL2RA ITGAX CXCL12 HSPA1A TERT PLCG1 IL31 NOD2 DKFZp686L0365 MRC1 IL18 TLR4 opn IL17A VWF IL4 CD19 CD3D CXCR1 CALCA HEL-S-30 NLRX1 DKFZp686L24211 TLR3 PS1TP5BP1 CREBBP VLDLR LTA EP300 TNFSF10 CD40 SYK PPARG PIK3CD CYBA APLN IRAK4 HMOX1 CD74 TXN RYR2 VIP PRKCA TNFSF6 MDM2 PTK2B CSF2 ADM AIM2 HSPA4 FGA NAMPT PLG FOS IL8RB CCL4 IFNAR2 PSPN ARTN NRTN ADAR TNC RET CXCR4 HEL113 ATP2A2 COMP BDNF TAB3 HEL-S-62p EGF BAD CS SQSTM1 FCGR2A CSF3 ACKR3 NOX4 LY96 PTEN MTOR TRPM7 BTK BASH CRP PTPN11 IL2 GDNF JUN SELE BAX CD14 PF4 CD44 CXCL2 PTH ADM2 ITGAM CCK CISH AGER CTSC RELA ZAP70 JUND MCL1 CALML3 MEFV SOCS1 H4C9 SIGLEC9 STAT3 PMC12235022__F7 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation CD14 CTSK STAT2 IRF7 TRAF6 IRF3 MYD88 TLR4 LBP CD40 TYK2 CD80 FADD TIRAP PMC6741895__F7 The FA pathways involved in ABeta-induced neuronal dystrophy FYN GSK3B CDK5 APP CBL PMC5063343__F5 Heat Stress and Lipopolysaccharide Stimulation of Chicken Macrophage-Like Cell Line Activates Expression of Distinct Sets of Genes HSPA14 DNAJA4 HSPA2 TRAF6 CCL4 HSF2 IL12B IFNG CASP3 IL18 TLR4 DNAJB6 CASP9 CD40 LITAF JUN RB1CC1 PMC3234268__F5 Genome Characterization of the Oleaginous Fungus Mortierella alpina CDIPT HEL-S-304 RPIA SMO GLYCTK ACLY ELOVL2 ACD RPE ACAT2 PMC5031209__F2 Apical signals inhibit nuclear YAP localisation EGFR SRC RHO PMC9553898__F8 Possible scheme depicting the role of mTORC1 signaling in estrogen-induced epithelial cell proliferation and differentiation in mouse vagina EREG YAP1 RPTOR PMC5437397__F7 RNA interference (RNAi) pathway members in malacostracans ME1 AGO1 AGO2 DERA DROSHA PMC5010773__F1 Representation of Canonical Wnt/Beta-catenin pathway HEL-S-11 APC MYC CCND1 RHO PMC7599158__F3 Proposed molecular functions for lncRNAs PICSAR and PRECSIT in cSCC MMP10 EGFR PMC11617869__F2 SSA significantly impacts cancer by inhibiting cell proliferation, inducing apoptosis, suppressing invasion, reducing cell growth, and alleviating skin toxicity BAD CXCR4 GC EGFR SRC NOX4 MTOR BAX PMC321741__F1 Signaling pathways for TLR-3 and TLR-4 TLR4 IRF3 TLR3 PMC4267955__F10 Loss of signaling via GA13 in germinal center B cell-derived lymphoma ARHGEF1 S1PR2 P2RY8 GNA13 ARHA PMC4409298__F7 BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses YAP1 CCL2 SMAD1 DKFZp781O1323 PMC5732027__F5 Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements AGO2 POLI PMC3680431__F7 Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties TLR4 GC IL1B CD36 PMC8073961__F2 Role of adiponectin in VSMC MFN2 ARHA IRS1 PMC11654178__F4 Upstream Pathway of Triterpenoid Synthesis in C MVD FDPS MVK HMGCR PMC4424351__F9 The role of UV radiation in the modulation of STING-dependent IRF3 activation TBK1 CGAS ULK1 AMBRA1 IRF3 PMC9676400__F7 Chicken anemia virus VP1 negatively regulates type I interferon via targeting interferon regulatory factor 7 of the DNA-sensing pathway TBK1 CGAS IRF7 PMC3318683__F12 A model of MMP-9 sorting and trafficking in activated macrophages CD63 RAB27A PMC5574206__F1 BMP signalling utilises canonical Smad dependant pathways and non-canonical Smad-independent pathways BAMBI RNF11 SMURF1 NEDD4 PMC8258627__F1 Advances in the role of autophagy in the development of retinoblastoma ULK1 TFEB ATG12 MTOR DKFZp686F0183 PMC3798270__F6 The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally AIDA ACHE SDHA HEL-S-5 PMC7408918__F1 Androgen at supraphysiological level (SAL) induces cellular senescence through the PI3K/Src/Akt/mTOR pathway SRC RAF1 MTOR PMC11594236__F1 Cellular mechanisms involved in OA synovitis in osteoarthritis S100A8 CCL5 CCL2 CCL3 PMC7408918__F2 AR antagonist induces cellular senescence in PCa through the Src/Akt pathway SRC RAF1 PMC11594236__F2 Cells of innate immunity and network of mediators in OA synovitis STAT1 CD14 GNLY CD209 PMC3411967__F1 Cell-proliferative signaling pathways in lung tumors EGF EGFR NRAS PMC6510479__F4 Epigenetic reprogramming of the innate anti-viral interferon response (IFN) RELA MYD88 EZH2 IRF-1 PMC3809064__F1 Targeting Mutant Fibroblast Growth Factor Receptors in Cancer IL1A FRS2 GRB2 SOS1 CBL PMC11854957__F1 Transcription Factor CcMYB330 Regulates Capsaicinoid Biosynthesis in Pepper Fruits CS AMT PMC9168780__F12 Emerging roles of cystathionine Beta-synthase in various forms of cancer TWIST1 SMAD2 ACLY SP3 PMC9192746__F5 Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation CD14 DAO MAX HP HELB PROC PMC12069211__F9 Construction of “KEGG pathway-target” network PDE4D TH AKR1B10 CA13 HSD11B1 ALOX5 AKR1C1 VILL ACHE CDK6 TLR4 HEL-S-11 XDH AKR1C4 ABCG2 CHRM2 NOS2 CA4 ABCB1 CYP1B1 MMP9 PTGES HSD17B2 MAFK REL PMC4392267__F8 Proposed model for the involvement of TRIP in the TNF-induced inflammatory response TRADD IL6 SPHK1 CSA2 TNF TRAF2 IL1B PMC7746852__F2 Alteration of host signaling pathways by HIV-1 NLRP3 CCR5 TRADD CXCR4 FADD PMC7746852__F3 Insights into the counteraction of host defense by viral protease and Vpu TBK1 PEX7 PEX2 IRF3 PEX11B PEX13 MAVS PMC9168780__F10 Emerging roles of cystathionine Beta-synthase in various forms of cancer PTEN MTOR CAMKK2 PMC9168780__F11 Emerging roles of cystathionine Beta-synthase in various forms of cancer KEAP1 BCL2 TYMS MTOR PMC3071576__F2 Proof of Concept Trials in Bipolar Disorder and Major Depressive Disorder: A Translational Perspective in the Search for Improved Treatments NACA PSD PMC7290051__F5 Interaction between imaging agents and the blood-brain barrier ABCB6 FECH UROD SLC25A38 HMBS ALB ABCB10 SLC22A6 ABCG2 SLC15A2 ABCB1 PBR PMC8739471__F10 Integrated Pharmacogenetics Analysis of the Three Fangjis Decoctions for Treating Arrhythmias Based on Molecular Network Patterns PLN PI3 BCR CAV3 HRC MCU CAV2 PMC11284386__F1 Systemic and renal iron homeostasis ERFE EPO HIF1A STAT3 PMC9331520__F3 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance HGF CXCL12 PMC9331520__F4 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance HGF APC GSK3B PMC5399110__F9 A schematic representation or summary of the alteration in endothelial cell signaling by aberrant NOSTRIN expression NOSTRIN TRADD TRAF6 PMC10148646__F1 Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection NOX4 DNMT3B HEL-S-22 PMC3091517__F2 Ras/PI3K/PTEN/Akt/mTOR Pathway and Potential Sites of Therapeutic Intervention MDM2 GRB2 SHE PTEN RPS6 MTOR DEPTOR EIF4B RHEB PMC3091517__F3 Interactions between the Ras/Raf/MEK/ERK, Ras/PI3K/PTEN/mTOR and Wnt/Beta-Catenin Pathways that Result in the Regulation of Protein Translation and Gene Transcription SALL4 TSC2 TSC1 RHEB PMC3091517__F1 Ras/Raf/MEK/ERK Pathway and Potential Sites of Therapeutic Intervention with Small Molecule Membrane-Permeable Inhibitors GRB2 EIF4E RPS6 EIF4B PMC7149907__F5 Oncogenic seRNA participates in carcinogenic processes through activating various signal-pathway CD47 SOX2 TP63 EGFR GSK3B MYC ARHA EZH2 PMC8196994__F1 Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections HEL-S-62p FH C6 C4A PMC9424846__F3 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection PMC9424846__F4 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection TRAF6 IL23R IL17RC IL1B STAT3 PMC4102832__F2 Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities GSK3B LRP6 H2AX PMC10742113__F1 Comparative signaling pathways mediated by adiponectin, leptin and resistin ADIPOR1 ADIPOR2 POMC TLR4 SOCS3 VCAM1 AgRP LEPR IL6 STAT3 PMC7526619__F1 Omega-3 and omega-6 long-chain fatty acids synthesis pathways compete for the same enzymatic machinery in the cell COX2 COX1 ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC10242764__F7 Molecular Mechanisms of Notopterygii rhizoma Et Radix for Treating Arrhythmia Based on Network Pharmacology CASP3 AIFM2 PERP ATM CDK2 MDM2 CASP9 PTEN MTOR ATR RFWD2 BAX PMC10742113__F2 Comparative signaling pathways of IL-6, PAI-1 and MCP-1 CCR2 SOCS3 STAT3 PMC3419619__F8 Protein kinase CD (PKCD) activation by proteolytic cleavage downstream of tumor necrosis factor (TNF) signaling in dopaminergic neurons TRADD TRAF2 FADD PMC10242764__F5 Construction of drug-compound-target-pathway network HEL-S-62p C9 C7 C6 PMC6959184__F1 The role of MYD88 signaling in normal physiology and lymphomagenesis BCR IRAK1 IRAK2 TRAF6 PLCG2 MTOR CD79A STAT3 PMC12190641__F1 Study flowchart SPTLC2 AMD1 IGSF3 PMC8599287__F7 USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN CDK4 PTEN CDC2 USP25 PMC8396448__F4 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina STAT1 TSC2 TSC1 SOCS3 LIF GSK3B PTEN EIF4E BDNF SGK1 STAT3 PMC10742113__F5 Bacterial degradation of trimethylamine (TMA) for trimethylamine N-oxide (TMAO) formation NLRP3 IMPACT PMC4425997__F1 The fundamental aspects of the DNA damage response pathway ATM BRCA2 ATR BAX PMC10742113__F3 Signaling pathway mediated by Escherichia coli lipopolysaccharides (LPSs) TLR4 VCAM1 TRAF6 MYD88 TNF IRS1 PMC8396448__F3 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina CASP3 BAD SP2 TRADD ATF4 CASP9 SP1 CAD TRAF2 FADD GSDMD BAX PMC7409273__F7 Proposed model of signaling pathways involved in HPV16 E7-mediated Pirin upregulation in oral epithelial cells PIR EGFR PMC8904921__F5 Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice MAF KEAP1 TNF NQO1 PMC3670266__F1 Circulating miRNAs as new activators of the JAK-STAT3 pathway IL6 SOCS5 STAT3 PMC8509312__F6 Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment NNT CIT MAL PMC2823977__F1 REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS TRADD TRAF2 FADD BAX PMC3613593__F1 Hedgehog pathway BOC GLI3 KIF3A RAB23 SMO GAS1 PMC6697777__F7 CaSR-mediated signaling and mesenteric artery relaxation CYP2J2 CASR NPS ADRBK1 PMC8526712__F5 Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy TRADD IRAK1 MADD IRAK2 MAP3K7 IL1R1 IFNGR2 IRAK4 MYD88 STAT1 JAK3 IFNGR1 IRAK3 TRAF2 FADD STAT3 PMC8430856__F2 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance TRIAP1 BAD PDK2 MDM2 PTEN PMC8430856__F1 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance TRADD BAX PMC2684550__F2 In MSTN-null mice, regulators of the PI3K pathway and cell survival/apoptosis likely contribute to muscle hypertrophy PINK1 BIRC5 PTEN PMC3855388__F4 CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis EREG SHE TEC PMC3787240__F2 Selected non-epigenetic effects of sulforaphane and I3C/DIM on prostate cancer cells SFN BCL2 PTEN MTOR CDK6 BAX PMC5397262__F2 Misregulated expression of members of the ubiquitin cascade contributes to the aberrant signaling of various pathways in cancer USP4 USP15 TRADD RNF31 RBCK1 SMAD2 VHL SMAD4 WWP1 TNF UBE2V1 UBE2S STUB1 SMURF2 SHARPIN HEL-117 PMC9562180__F2 Macrophages, Chronic Inflammation, and Insulin Resistance TLR4 SOCS3 TRADD IL6 MYD88 TRAF2 IL6R IRS1 PMC4670915__F5 Scheme of the metabolic effect in control and differentiated SH-SY5Y cells MDM2 SIRT3 PMC8359344__F2 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism SIRT6 DHFR ELOVL6 GLS PMC8359344__F3 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism MFN1 FLCN CDK2 APC CDK5 RALA CDK4 TXNIP CDC2 CDK6 PMC4591129__F3 Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle UBC PLTP SCD UCP1 AQP7 HEL-S-28 LPL PMC6791268__F2 Oncogenic activity of Bacteroides fragilis and Salmonella enterica CXCL1 CXCL5 SMO CXCL2 STAT3 PMC10673274__F1 Sites of cellular PPi formation and details of galactose metabolism PPA2 HEL-S-66p PMC7840349__F2 Recent Updates of Lipoprotein(a) and Cardiovascular Disease TFPI PLG TEC PMC8960856__F4 MicroRNAs in Serum Exosomes as Circulating Biomarkers for Postmenopausal Osteoporosis ROCK2 BAMBI INVS CBY1 STOM APC SOST CER1 SMAD4 SKP1 RYK ARHA WAS NLK PMC10914313__F7 The mechanism by which ARM promotes chemoresistance via PPARG/ABCG2 pathway ABCG2 TF CD36 PMC2484121__F2 Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs): Multifunctional proteins in cancer PI3 CD44 PTEN DMP1 PMC11978139__F2 Molecular processes underlying CXCL2 secretion TLR4 SOCS3 CXCL2 STAT3 PMC2725207__F3 Tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1 RFC2 RFC3 RFC4 PMC3197364__F6 Hypothesized mechanisms for sphingolipids in cardioprotective signaling in response to ischemia or hypoxia PAK1 HEL164 SKI TNF PMC11953409__F1 Metabolic pathway shifts in T cells TSC2 TSC1 APC RHEB PMC6283435__F3 TF cascades under glucagon control KLF15 EGR1 TFEB YY1 PMC8574228__F5 Metabolic flexibility and HFpEF LPL SIRT1 CD36 HEL-S-5 PMC8574228__F2 Fibrotic–inflammatory remodelling in heart failure with preserved ejection fraction SPARC COL3A1 SMAD2 MMP9 SMAD4 COL1A1 MMP3 TRPC1 MMP2 VCAM1 TRPC6 TRPC3 STAT3 PMC8327170__F3 Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma IGF1R IGF1 TRAF3 PMC6146524__F4 Galactose metabolism, glycosylation and inflammatory cascades in galactosaemia ALG9 LEP FUT8 ANXA1 MGAT3 UGDH LEPR PMC8574228__F1 Signalling pathways in cardiac hypertrophy GCA RGS4 CNP RGS2 RHO EIF4E MTOR IRS1 SIRT3 PDE9A PLN TRPC1 HEL-S-11 TRPC6 TRPC3 PMC9353479__F6 Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip EGFR MYC CCND1 MTOR PMC8038842__F2 Human mitochondrial fatty acid biosynthesis (mtFAS) pathway LIPT2 LIPT1 LIAS ACSF3 DBT PDHX MECR DLAT MCAT OXSM HTD2 PMC4629004__F3 Changes in genes encoding components of the glycolytic, TCA cycle, and mitochondrial NADH shuttle pathways in gastrocnemius muscle in response to BCATm KO CS PFKM MDH2 SLC25A12 SLC25A11 GOT2 ACO2 GPD2 OGDH SUCLG2 HEL-S-133P SDHD HK2 PGAM2 SDHA HEL-S-281 SDHB GPD1 ENO3 FBP2 SDHC HEL-S-30 ENO1 DLD HEL-S-87p SLC16A3 HEL-S-162eP HEL-S-68p SLC2A4 SUCLG1 SUCLA2 PMC4408550__F1 Activation of TGFB requires liberation of the TGFB dimer from an inactive latent complex with the LAP PLG ARHA FURIN PMC4629004__F2 BCATm KO on protein synthesis pathways RPS7 RPL35A RPSA RPL19 RPS26 RPS29 RPS24 EIF3G EIF3E RPS18 EIF3S2 PPM1L FAU RPL36A EIF3K EIF3D RPS19 RPS4Y1 EIF3M EIF3B RPL23 RPS20 HEL-S-310 RPL18 EIF4E RPS16 IRS1 DDIT4 EIF4G1 RPS10 ELF3 EIF3S3 RPS3 RPS6KA2 ELF5 RPL22 RPL27 PPP2R1A EIF2AK1 EIF5 RPL11 RPS5 RPS2 RPS27A RPL21 EIF2A RPS6 EIF4B RPS12 RPS15A PPP2R3A ELF2 RPS14 RPL13a SUI1 RPL38 PPP2R5A RPS15 RPS8 RPL15 RPS9 EIF3C RPL8 RPS25 EIF3F RPS17 PAIP2 AAG1 RPL27A RPS21 PMC8613644__F2 Cell-free network communication in alcohol-associated disorders and liver metastasis SDCBP PLEC RAB27A HEL-S-101 AKT1S1 HPSE ZFP36 HTT HGS ADARB1 RAB9A EXPH5 RAB27B TGFA PMC4278286__F4 Altered metabolic pathways in clear cell renal cell carcinoma: A meta-analysis and validation study focused on the deregulated genes and their associated networks PLSCR1 HIF1A STAT1 FLT1 BHLHE41 NR3B3 SP1 SLC12A1 PSMB9 SPAG4 PSMB8 GATA3 NPHS2 CD14 ALDOB SCARB1 SLC34A1 EHD2 VEGFA LHX1 CA9 HEL-S-87p TIMP1 LIPA BTG1 ENO2 IGFBP2 HEL113 ABCA1 STAT3 PMC3895605__F2 Possible signalling pathways involved in enteric neurogenesis by a 5-hydroxytryptamine 4 receptor (5-HT4R) agonist mosapride citrate (MOS) KIF26A RET MOS EDNRB GRB2 GDNF RHO PTEN SPRY2 CDC42 TRIR PMC8699756__F3 Transcriptome Analysis in Vulvar Squamous Cell Cancer WEE2 ANAPC13 ANAPC7 E2F4 ANAPC11 HEL2 CDC23 HEL-S-1 ANAPC2 MYC CDC37 TFDP2 SPN CDC45 FZR1 EFS MCM3 CDC20 MCM2 ATM CDC27 ANAPC10 PMC3703268__F6 Network view of TGF-beta signaling pathway alterations in colorectal and ovarian cancer TGIF2 NCOR1 MAP2K4 MAPK3 SMAD2 TGFBR1 MYC TGFBR2 SMAD4 HSF1 CLU PPP2R2A MYBL2 MAPRE1 SKIL ZFYVE9 ZNF7 APC CPNE1 MAP3K7 NCOA6 CREBBP HNF4A EP300 MAP2K1 TRIB1 FOXH1 PMC6685260__F5 Molecular characterization of subpathway signatures GABARAPL2 CHUK c-fgr PGR GSK3B GNAI3 GNGT2 RAF1 GNB1 GABARAP PMC10743556__F2 Keap1/Nrf2/ARE signaling pathway KEAP1 NQO1 PMC3188957__F4 Highest confidence network of genes influenced by CLOCK knockdown S100P UGT2B10 MGAT3 UGT2B17 ANTXR1 UGT2B15 CD36 PMC3534992__F7 MiR-146b function in IEC-6 cells mediating TGFB signaling SMAD2 SMAD4 SIAH2 PMC8039382__F2 Metabolic and signaling networks involved in anoikis-resistance mechanism EGFR MYC PTEN MTOR FASN STAT3 PMC8103695__F5 Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo TSC2 TSC1 GSK3B DEPTOR IRS1 RHEB PMC4170681__F1 The genetic signatures of pediatric high-grade glioma: no longer a one-act play CCND1 CDK4 CCND3 CDK6 CCND2 PMC4882600__F8 RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells RASSF1 BMP2 GSK3B CCND1 CDK4 LATS1 LATS2 CDK6 PMC8088956__F2 Dysregulation of Wnt/B‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application NLK EGF HGF APC EGFR GSK3B AXIN1 LRP5 NEK2 LRP6 PAK4 PMC6165531__F1 The sugar metabolism (green) and signaling (blue) pathways OGT TES RGS1 FIS1 PMC3089884__F5 Chemokine Signaling Pathway RAG1 SHE CLU PMC7603127__F2 NRF2 directs numerous metabolic processes that impact cancer cell survival and proliferation, including NADPH production and the metabolism of lipids, amino acids, nucleotides, and iron/heme (a) ME1 GCLM GPX4 GCLC SHMT1 HMOX1 TXN MTHFD2 PHGDH HEL-S-26 FECH PSAT1 ASNS HEL-75 HEL-S-51e HEL107 GLS PMC9406467__F3 Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer? CHEK2 ATM VRK1 PMC4935811__F3 Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards CX3CR1 IRF8 ARG1 PMC4736825__F4 Model of translational repression of Nodal pathway components XCR1 ELF3 NODAL YBX1 PMC6393772__F6 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways BRAF ZEB2 SRC CDH2 PMC6393772__F7 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways BRAF GSK3B SRC PMC7432012__F3 Tumor necrosis factor beta (TNFA), interleukin 1 beta (IL-1B), bone morphogenetic protein (BMP), and transforming growth factor beta (TGFB) are stiffness-dependent signaling pathways ALPL RUNX2 SMAD2 ATF2 SMAD4 MAP3K7IP1 SMAD1 IL1B DKFZp781O1323 COL10A1 PMC3931462__F8 Proteolytic cleavage of CDCP1 contributes to enhanced tumor cell survival and motility through the FAK and Akt signaling pathways downstream of complex formation between cleaved CDCP1 and B1 integrin PLG SRC CDCP1 PMC7432012__F4 Material stiffness-induced Wnt signaling APC LRP5 LRP6 PMC9534854__F9 BNC1-Merlin-Hippo-YAP signaling -Ferroptosis axis BNC1 GPX4 FACL4 NF2 LATS1 LATS2 PMC6393772__F2 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways LIMK1 RHO PDPK1 PMC8750485__F1 Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases NAMPT KYNU KMO NNMT SARM1 PMC11847137__F9 Schemic working model revealing the possible role of ZC3H15 in mediating BCP KEAP1 GCLC ZC3H15 NQO1 PMC5604081__F1 Regulation of intrinsic cancer metabolism by obesity-associated growth factors IGF1R CS IGF1 MYC HEL-75 ACLY MTOR HEL-S-133P HK2 PMC9434279__F1 Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus IL1B IAPP PMC3732476__F2 Notch signaling pathway MAML1 ADAM10 ADAM17 PMC7555059__F1 Hierarchy of repair pathways choice in mammalian cell POLE BRCA2 RAD52 RAD51 BRCA1 PAXX PMC6240761__F1 Hypothalamic-pituitary-adrenal axis signaling CCR2 IGF1 CRH GC EGFR GHR CCL2 TNF PMC7555059__F4 Proposed antagonistic relationship of 53BP1 and BRCA1 during DSB repair pathway choice based on DNA resection RIF1 ATM H2AX BRCA1 PMC3121899__F3 Cartoons of PAR-1-dependent signaling by APC and thrombin in endothelial cells when EPCR is either free or occupied by protein C PC ARHA RAC1 PMC2806113__F6 Working model of TGFB actions in renal interstitial fibrogenesis TSC1 MTOR PMC6719047__F2 RTT-related protein known functional interaction networks TRRAP CHD4 ZBTB18 ZFX RHOBTB2 CACNA1I KCNQ2 SCN2A ZNF620 GABBR2 HOMER2 MEF2C NCOR2 PMC6518824__F3 Schematic indicating the pathway from Micronucleus formation to activation of the cGAS-STING pathway, and canonical and non-canonical routes to Type I interferon response CGAS RELB IRF3 PMC9629402__F7 In Silico and In Vitro studies of taiwan chingguan yihau (NRICM101) on TNFA/IL-1Beta-induced human lung cells CD14 MAPKAPK2 TNFAIP6 FOS MAP3K7 CXCL8 TRAF6 IL6 TNF COL1A1 MAP3K7IP1 LBP TRAF2 JUN PMC7690798__F2 Functional interaction network and molecular classes of the 20 genes with high RNAi efficacy from LARP1 EEF2 EGFR LONP1 RPL37 PSMB3 HSPD1 RBX1 EIF3E TBC1D3B SARS1 ERBB2 POLR2L EIF3B SNRPD1 SF3B2 RAN RPL5 RPL7 SNRNP200 RPS15A TERT PMC6438456__F10 Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers RICTOR HEL-S-11 APC EGFR GSK3B PTEN MTOR MLST8 PMC6535785__F7 Probable molecular mechanistic pathway of ruthenium baicalein complex CASP3 MTOR PCNA BAX PMC5312370__F6 RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy RAD51 PARP1 MTOR STAT3 PMC8436408__F1 Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NFKB Modulators TLR8 COX2 TLR7 PMC4447524__F1 Resistance to BCR-ABL1 tyrosine kinase inhibitors may take the form of (left) point or compound mutation-based, BCR-ABL1-dependent resistance or (middle) recruitment of alternative pathway signaling upon effective inhibition of BCR-ABL1 FGF2 SRC POR CP STAT3 PMC2956608__F1 Inhibition of the type I interferon (IFN) pathway of Kaposi's sarcoma-associated herpesvirus (KSHV) TBK1 CD14 IRF7 IRF6 PMC8453146__F2 Kill and Clearance in HCC: An Approach Based on NK Cells and Macrophages CX3CR1 CX3CL1 CD40 CCL5 CCL4 CCL2 ARG1 CCL3 PMC6616015__F2 Gene-gene interaction networks HEL-S-75 MALL ARHGAP18 NRARP PRIM2 CARD14 CBX1 ANGPT4 CDK2 EPHX4 OGDHL KCTD9 ADGRG6 RIMBP2 REL TRIM27 ZBED4 RADIL SMN1 PMC2921274__F2 Eph receptors and ephrins in cancer: bidirectional signaling and beyond SRC HRAS EPHA2 EPHB2 PMC7390515__F2 TGFB signaling in health and disease SMAD2 SMAD4 PMC8699427__F2 Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease IL18 PER2 PER1 PMC2082051__F5 Networks of pathways unique in the HIV-1 regulated mPBMCs BRAF RPS6KA1 MAPK3 ZAP70 CD244 CTLA4 PTPN6 HLA-DRB1 HLA-DMB KLRC2 HLA-DMA TYROBP PMC4920181__F5 An illustration showing roles or functions of analyzed retinal disease-related genes CRX PCDH15 USH2A NR2E3 RPE65 SAG RP1L1 KCNV2 NPHP1 CC2D2A FZD4 TLR3 NDP RP1 RDH12 RPGRIP1 OTX2 TUB GUCY2D RD3 CRB1 PMC10859375__F5 Lipid laden macrophage accumulation in the p DGAT2 SCD PLIN1 LPL ACSL1 NPC2 HEL-S-104 PLIN4 CD36 PMC7542331__F5 Regulatory loops around TGFB1 link important transcription factors and cytokines EGR1 TWIST2 RUNX3 SNAI1 CCL5 FOXO1 EDN1 NR1i1 TWIST1 KLF2 KLF9 EZH2 TGFB1 PMC6465591__F1 Lymphatic vessel functions during tumor progression VEGFC VCAM1 CXCR4 CCL21 CCR7 CXCL12 PMC1087229__F8 Signaling pathway of NGF-induced neurite outgrowth in PC12 cells VAV3 NGF RAC1 SOS1 CDC42 VAV2 PMC5293580__F5 Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways MAP4K3 MTOR RHEB PMC11622859__F4 Reconstitution of the biosynthetic pathway of CNs in this work and the semi-synthesis of ISIR-050 IPP PMC5386521__F1 Scheme depicting a molecular pathway by which Cdc25A is induced/activated and promotes neuron death in disease and development MYB CDK4 PMC3606047__F1 Adenosine Signaling During Acute and Chronic Disease States ADORA2A ADORA2B AHR PMC2921274__F4 Eph receptors and ephrins in cancer: bidirectional signaling and beyond FYN LCK ARHA PTEN PMC7214542__F1 Regulatory and catabolic pathways for glucose and xylose metabolism in E PTS CRP HPR GALP PMC3241422__F10 Control of Rho1 activity through the cell cycle ROM1 HMFT1766 PMC3724215__F1 IGF pathway BAD IGF1R IGF2 PTEN EIF4E MTOR EIF4EBP1 INSR IGF1 GRB2 EIF4B SHC1 IGF2R PMC7972191__F7 Graphic abstract showing how the KPNA2/CBX8/PRDM1/c-FOS pathway works in BCa BCOR CBX8 KPNA2 PMC5870182__F6 Schematic diagram illustrating the mechanism of WYHZTL formula in regulating Wnt/Beta-catenin signaling pathway APC GSK3B CCND1 PMC12163303__F2 Mechanisms of translation regulation TSC2 EEF2K TSC1 EEF2 GRB2 RHEB PMC3426818__F5 MUC5B gene expression is transcriptionally regulated by various mediators and pathways ERBB2 ERBB3 IL17A SP1 MUC5B IL1B PMC9623415__F1 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer MTOR PMC4240652__F6 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet TIAM1 CXCR3 SHE ARHA JAK3 CRK PMC4240652__F8 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet PPP3CA DAO APC CD48 CTLA4 TNF CBL ITK VAV3 FYN BCL10 LCK GRB2 IL2 CDK4 IL4 LAT CD3E PMC11002873__F3 Working model for the Wnt, TGFB, and Pax6 signalling in the regulation of ciliary body development LEF1 SMAD2 MSX1 SMAD4 MSX2 AXIN2 SMAD1 DKFZp781O1323 BMP4 PMC4163376__F2 Simplified overview of the Rb/E2F pathway MCM3 MCM5 MCM6 MCM2 MCM7 PMC3148569__F6 Perturbed TGFB/Smad and mitogen-activated protein kinase signalling pathways in Dupuytren's fibroblasts BMP6 NODAL SMAD2 COL1A2 SMAD4 PMC7520270__F5 Enrichment and functional annotation by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) PLEKHH2 HEL-S-116 KDELR1 GINS1 STK39 CHD3 SLC39A11 SYTL2 UBC DAG1 ALDH5A1 COX2 ARL2BP ALDH7A1 ANXA2 SLC35A3 CRABP1 PFKP RAD51C ANXA1 CRABP2 FTH1 FTL HMGCS1 ENO2 HEL-S-66 STX3A EPHA2 SLC11A2 PMC8458764__F1 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight APC LRP5 LRP6 TCF7L2 ARHA RYK RAC1 CDC42 PMC5858703__F4A Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease CD5L IL23R STAT3 PMC7764399__F2 Various gut microbial stimuli due to dysbiosis can cause the initiation of inflammation in the intestine TH NLRP3 CARD9 IRGM IL23R TGFBI BAX PMC8458764__F2 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight APC GSK3B PMC7284378__F5 Proposed mechanisms for protective effects of MWF on chronic alcohol-induced liver injury LPA HMGCR ACAT2 PMC8882905__F4 Antiplatelet Therapy in Patients With MINOCA IL1A COX1 VWF PMC5963346__F3 DEGs associated with TNF signaling pathway at different time points after cerebral ischemia CASP3 TNF MLKL PMC9623415__F2 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer GSK3B CREB1 CDK4 MTOR PMC6462347__F5 Schematic overview of the folate metabolic pathway mediated by FOLR, DHFR, and MTRR MTR FH DHFR MTRR PMC4803789__F2 Molecular regulation of autophagy ULK1 ATG16L1 ATG12 ATG3 BCL2 WIPI2 ATG101 UVRAG ATG10 DKFZp686F0183 PMC12006828__F15 Biosynthetic gene cluster and (B) proposed biosynthetic pathway of stipitatic acid TSR3 TSR2 TSR1 PMC7002875__F8 KDM5C is a SAHA-sensitive marker of a druggable pathway damaged in NDDs SCN2A KDM5C ZNF711 SYN1 ARX BDNF PMC12006828__F11 Biosynthetic gene clusters and (B) the proposed biosynthetic pathways of helvamide B and arizonamides PARG ATR PMC6441734__F6 JNK pathways in mammals and drosophila ME1 LRRK2 ATF2 PMC3575449__F1 From photomorphogenesis to cancer CSN3 MDM2 CSN2 RFWD2 SKP2 PMC6477797__F6 Biological pathways associated with non-synonymously mutated genes in TCL1 mice PIK3R1 MED12 ARHH NPM1 EGFR TRAF3 ITGA7 PTEN MTOR NR1C1 IKBKB PI3 BCR NUTM1 F3 CD40 ELF4 PMC6322364__F7 TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress FANCD2 CDC2 TIA1 ATR BRCA1 PCNA PMC8436938__F13 Siberian fir terpenes extract Abisil on antioxidant activity, autophagy, transcriptome and proteome of human fibroblasts E2F4 ORC6 GSK3B SMAD4 STAG1 DBF4 ORC3 CDK7 STAG2 CDK6 CDC45 ORC2 CDC20 CDC6 SMC3 CDK2 MDM2 CDK4 CDC2 MED1 PCNA SKP2 PMC4256277__F4 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway TLE3 LGALS9 GOT2 FDPS SRC TXNDC16 ARHGAP22 SEC61A1 SLC39A14 MUSTN1 CMKLR1 STARD8 ASPSCR1 THAP7 ERGIC1 TRIM2 EHD1 BAIAP2 LRP5 LRP6 MGAT1 HSD3B7 DOLPP1 USP36 NR1D1 DNA2 PMC4256277__F2 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway VPS18 CPT2 RHO RPL35A MTOR SRC CAD ARHGAP22 TFAM PARVG STARD8 ASPSCR1 ERGIC1 MTIF2 TRIM2 EHD1 TATDN3 BAIAP2 SCRN1 RAB40C QSCN6 CHCHD7 PAPOLB CYTIP STARD7 ADHFE1 HSD3B7 MYO7A NIPA2 DOLPP1 FHDC1 COQ3 TMEM109 PXMP2 PMC3596326__F4 Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism AMN PMC3805607__F3 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks SPARC TH PRKCZ MARCKS PROS1 AMACR GCDH POLE MMP2 HEL-S-8a HAGH CELF2 MGP VEGFA RRAD HFE PILRA STAP2 AMN ALPL ITGAM SELPLG CCK PROZ PLTP APEH HEPH IL3 MSRB2 RELA LYN PMC4760780__F7 Proposed model for Usp12 function in the pathway of TCR signaling USP12 USP46 TRAT1 LAT PMC5732848__F1 Environment Matters: Microglia Function and Dysfunction in a Changing World HEL-S-62p IGF1 NGF BDNF PMC8465283__F1 p53 mRNA Metabolism Links with the DNA Damage Response PML POLK PLK4 MDC1 XPC GADD45A BRCA1 RAD17 ATM TOPBP1 HUS1 ATRIP ATR BAX PMC3805607__F2 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks PRKCE F2R FLNA RELB DOCK10 CCL2 PLD4 MTHFD2 OSMR ACADS RHOB RRAS CLDN4 ASPA HEL-S-130P TAGLN HLA-C TYROBP ABAT CTSC ASNS PARP2 LITAF MCCC1 HEL-S-51e PLEK DOCK2 PYCARD TGFB1 STAT3 PMC9709205__F3 Impact of SOX2 function and regulation on therapy resistance in bladder cancer COX2 SOX2 IGFBP1 IGF2 PMC10417115__F2 miRNA binding sites at the rs8720 and rs12587 variants of the KRAS gene and their function in tumor regulation PTEN SP1 PMC3947785__F1 What’s the Mtrr with your grandparents? MTR F2 F3 MTRR PMC9532536__AF1 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway PLK1 A2M FOXM1 CCNB1 KIF20A CDC2 PMC3567816__F1 A summary of the newly proposed inflammasome activation pathway including PKRs' recently found role NLRP3 HMGB1 NLRC4 NLRP1 AIM2 IL1B PMC8003318__F2 miR-29a and HCC carcinogenesis APAF1 MDM2 PTEN MCL1 SMARCE1 PMC8003318__F3 miR-29a as an epigenetic modifier AFP TET3 SETDB1 MMP9 SOCS1 TET2 TET1 PMC8003318__F4 Role and mechanism of miR-29a in metabolic adaptation SPARC ROBO1 SIRT1 PMC8003318__F5 ceRNA acts as miR-29a sponge to positively promote HCC progression ROBO1 C22orf13 TUG1 MCL1 PMC8003318__F6 miR-29a as a regulator of tumor microenvironment LOXL2 IGF1R CLDN1 IFITM3 VEGFA ROBO1 STAT3 PMC8405630__F4 Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy RRN3 TBP ATM CDK2 MDM2 CDK4 CDC2 CDC25B ATR CDK6 PMC5030232__F7 Major metabolic pathways anticipated to participate in spore germination process in N HEL-S-304 RPIA ADK PMC6473282__F6 Proposed regulatory mechanism of estrogen in colitis-associated colorectal cancer at week 2 (A) and at weeks 10 and 16 (B) NLRP3 COX2 GCLM GCLC TNF PMC5435615__F5 Diagram of heme effect MAP2K4 IRAK1 TRAF3 TRAF6 HEL-S-92n IRAK4 IL6 MYD88 MAP2K3 TNF MAP3K7IP1 NLRP3 TLR4 TRAM1 ECSIT TXNIP CD80 TRAM2 TRAF2 TIRAP TAB3 PMC4116803__F1 Improving GD T cell functions by TLRs in combinatorial therapy MICA IPP CD69 PMC8301900__F3 Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway BAD FOS CDK4 PTEN MTOR CDK6 PMC6834161__F2 Working model of FH physiopathology and the effects of CoQ PCSK9 LDLR ABCA1 PMC7882549__F2 Mevalonate pathway and possible mechanism of action of statins EGFR BCL2 RHO BAX PMC6617458__F3 Microbial N-cycle and chitin convergence and degradation pathway mediated through the addition of chitin KIN NAPA PMC8944541__F5 Venetoclax-Resistant MV4-11 Leukemic Cells Activate PI3K/AKT Pathway for Metabolic Reprogramming and Redox Adaptation for Survival EN2 EN1 PMC6607732__F1 STING pathway activation in DNA repair deficient breast cancer TBK1 CGAS CXCL10 IRF3 CCL5 CD80 CTLA4 LAG3 FOXP3 PMC5431893__F1 Pathway of “aryl hydrocarbon receptor signaling”-initiated smoking-related cancer DUSP4 SMARCA4 AHRR AHR SMAD6 PAH PMC7506147__F1 In the cytoplasm, PTEN mediates dephosphorylation of PIP3 to PIP 2 which inhibits the PI3k/Akt/mTOR signaling pathway leading to slower tumor growth BMI1 PTEN MTOR PMC4442271__F1 Obesity, immunomodulation and chronic kidney disease COX2 LTA COX1 LTB IL6 PMC7998562__F1 Complement activation pathways HEL-S-62p CD59 C9 C4B_2 CD46 FH C7 INS C6 CD55 C4A EED PMC10311182__F1 Key piece of the airway remodeling puzzle revealed—LIGHT signaling in the lung TRAF3 RELB TRAF2 LTBR PMC8864109__F6 lncRNA Mirt1: A Critical Regulatory Factor in Chronic Intermittent Hypoxia Exaggerated Post-MI Cardiac Remodeling ANGPT2 BMP3 RHO RDX ALPL LAMA1 AGO2 ATXN1 PAX5 ZEB2 GREM2 OTP TUBB4A VTI1A INHBA SAP30 ALPI CNGA4 PMC8289790__F1 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment IL10 SMAD2 SMAD4 HIF1A MTOR NR1C1 STAT3 FOXP3 PMC8289790__F2 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment CPT1A SMAD4 PTEN MTOR FOXP3 PMC6429583__F2 Homology of the GSH synthesis pathways in mammals and Caenorhabditis elegans GCLM GCLC GC PMC3670113__F1 Role of SHIP1 in bone biology PI3 GIG8 GSK3B PTEN INPP4B USP1 PMC2842081__F1 Telomeres: protecting chromosomes against genome instability ATM BLM DKC1 TPP1 ATR WRN TERT PMC5842023__F8 T cell receptor signaling pathways in eosinophilic asthma ITK FYN BCL10 DAO CD2 LCK ZAP70 GRB2 CD48 CDK4 LAT CBL PMC6888549__F1 Wnt signaling pathways APC SOST LRP5 LRP6 PMC6547487__F5 Functional significance of several key genes from four KEGG pathways differentially expressed in female and male magpies EEF2K HNF4A RUNX1 ATM APC JAK1 RORA JUN LAT PMC6189633__F3 Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity TRAK1 BACE1 MAPK9 ATPAF1 LRRK2 CS PRDX3 COX5A CASP3 CPT1A PSEN1 HEL-75 GPD2 APH1B PMC5522964__F1 Epithelial to mesenchymal transition (EMT)-inducing transcription factors and the reported E3 ubiquitin ligases that govern their stability FBXL14 MDM2 FBXW8 PMC5832878__F7 DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/Beta-catenin pathway via GSK3B APC GSK3B CCND1 PMC6890794__F7 Summary of changes to the Wnt pathway as a result of AD + TS treatment CASP3 CD44 STAT3 PMC2657106__F1 Activation of the G2/M checkpoint after DNA damage PLK1 WEE1 ATM APC CDC2 ATR MYT1 PMC8859819__F4 Epigenetic regulation of inflammation by microRNAs in post‐infectious bronchiolitis obliterans PIK3CD EPOR CCR2 IFNA21 CXCL8 CXCL3 CCL2 OSMR DCN BMPR2 KDR ACVR2B CCL24 TNFRSF10D CCR7 BMP5 FOXG1 CCL19 CCL25 TNLG5A ATG12 CCL26 VEGFA IL8RB IL25 IFNAR1 IRS1 CD27 SMURF2 CCL20 SIRT1 IGF1R ROCK1 TGFBR1 ACKR3 TGFBR2 BCL2L11 PPBP CXCL16 NOG IL17A IL22 ZFYVE16 KIT GDF5 ACVR1 FOXO3A BMP2 CCR4 SKP1 CXCL2 BCL6 RPS6KB1 CREBBP BMPR1A IL6ST FLT3 SOS1 DKFZp781O1323 SKP2 INHBA INHBE PMC9194136__F5 Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling ME1 GOT2 ACLY HEL-S-133P FASN MAL PMC6120815__F1 Innate Immune Signaling and Alcohol Use Disorders HMGB1 CCR2 TLR7 TLR4 IRF7 TRAF6 IFNG PMC7407180__F5 Proposed biosynthetic pathway leading to terpenoids in A MVK IPP PMC4398671__F8 Schema of structure and signaling pathway of G-CSFRI and G-CSFRIV TP53INP1 SOCS3 CCL2 PMC2667983__F4 Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia TIGAR SCO2 LIF MDM2 PMC8224255__F2 Efficacy of phytochemicals as immunomodulators in managing COVID-19: a comprehensive view IL2 IL6 ACE2 PMC8883632__F10 Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma FER CLEC2D ALOX15 IFNG PMC9382640__F2 Mechanisms and prospects of circular RNAs and their interacting signaling pathways in colorectal cancer GSK3B MTOR PMC7666199__F4 Reconstructed hydrogenotrophic methanogenesis metabolic pathway with associated carbon fixation through the reductive Acetyl-CoA pathway, methane metabolism and coenzyme biosynthesis by Methanobacterium sp MTR POR PMC5244562__F1 Scheme of PI3K pathway with candidate regulators of mTORC2 colored in green RICTOR MTOR IRS1 MLST8 PMC4433776__F1 HHLA2 interaction with two receptors to regulate T cell functions TMIGD2 HHLA2 APC PMC5915062__F4 Proteomic alterations in early stage cervical cancer CRABP2 PPL CALU HEL-S-84 FLNA ATP1B1 EVPL ATP6V0D1 IVL DSC2 TOP2A PTPRF CDK6 TUFM GBP1 JUP PKP1 DSG2 FHL2 DSG3 KRT13 CDK4 KRT10 PMC5915062__F5 Proteomic alterations in early stage cervical cancer MRM3 HEL-S-99n MCM7 MTHFD1 FMR1 SMARCA5 MYO1E TACC2 RFC3 NELFE FEN1 MCM3 RFC2 MCM5 MCM6 PLAA MCM2 RRM2 HEL-S-269 SMC2 PRKDC PCNA PMC5915062__F2 Proteomic alterations in early stage cervical cancer PCM1 PCLAF TPR HEL-S-107 RB1 XBP1 KDM5A ORC2 FEN1 RFC1 MCM3 MCMBP KAT7 S100P LMNB2 MCM6 RABL6 PLAA WDHD1 FOXK2 PAX8 PMC5915062__F3 Proteomic alterations in early stage cervical cancer NAMPT HEL-S-99n DDX3X TPR HEL110 RIC8A NUP153 MCM3 SMC1A MCM5 MCM6 ERAP1 PLAA MCM2 NUP93 HEL-S-269 SMC3 WDHD1 NUP98 PSMB9 PMC7891830__F2 Golgi resident proteins and membrane trafficking pathway ATP2C1 ARFGEF2 ZNF547 FGD1 CGN PMC9279440__F5 Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer PIG59 CYLD H2AX FADD TLR3 PMC5935095__F3 Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape MTAP MTOR PMC4377623__F2 Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis LAP3 PMC9020266__F1 Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair PALB2 ATM BLM BRCA2 RAD52 RAD51 PNKP BRCA1 PAXX PMC6538740__F1 Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment PML PIN1 CHUK SFN HEL-S-1 EGFR MYC MAPK14 PPP2R1A LRPPRC RB1 MTOR POR TOP2A EEF1G CHEK2 UBC DKFZp686L0365 ELAVL1 KDR NR1i1 HEL-S-11 APP SRC CCND1 PRKDC HSPA4 TUBB YBX1 VHL PARP1 CDC37 TRIM26 PS1TP5BP1 NFKBIA CREBBP STUB1 RELA RAF1 VCP ATR SIRT1 STAT3 PMC7407977__F9 Molecular signal pathway of the proposed cell death crosstalk in B16 cells exposed to plasma induced-ROS DKFZp686F0183 FADD BAX PMC8378592__F2 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways IL16 CSF3 IRF9 ACE2 GRAP IFNG CCL3 PMC9662279__F5 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases NAMPT MTF1 SIRT6 RELA TRPM2 TNF SKP2 PMC8378592__F3 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways CD14 NGF TRAF3 LTB TRAF6 TRIM25 EDAR LEP BTK COX2 IL16 LTA TLR4 BCR ATM VCAM1 BASH CD40 SYK TRAF2 LAT TIRAP PMC3145778__F9 Redox-Induced Src Kinase and Caveolin-1 Signaling in TGFB1-Initiated SMAD2/3 Activation and PAI-1 Expression EGFR RHO PMC9662279__F7 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases ATG12 SIRT6 SP1 REL MTOR FOXD1 RHEB GATA4 PMC7201075__F1 Arachidonate-prostanoids pathway gene expression in colorectal cancer (CRC) tumors PTGER2 PTGIR PTGFR PTGIS PTGS2 PTGES PTGER4 PTGER3 PTGS1 HPGD PTGER1 PTGDR PTGES3 PMC4325920__F1 Roles of FMRP in the pathogenesis of AD MAP2 GSK3B PTEN EIF4E MTOR SYNGAP1 RHEB TSC2 NF1 TSC1 PAK1 FYN MAP1B APP ARC PMC3536146__F8 Pathway representation of canonical and Pyk2-mediated TLR9 signaling TBK1 TLR9 IRAK2 TRAF3 SHE TRAF6 IRF3 MYD88 JUN FADD PMC10526250__F1 Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression BAD BAX PMC3322338__F1 Hypothetical model for neuroimmune-related actions of miRNAs in brain of human alcoholics (e.g., in microglia) TLR4 SOCS3 IRAK1 IRAK2 CXCR4 TRAF6 IRAK4 MYD88 PMC5187688__F5 TCA pathway ME2 CS PMC5379509__F8 Novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks VASP MIB1 TBL1X RNF31 WAS CCNC UBB CDK6 NCK1 NKAP UBC AGO1 LCP2 BCL10 ZNF423 HGS ETV2 SNW1 SPEN NEUROD1 WDR12 DTX2 MESP2 RBX1 PTPN22 RELA GRAP2 THEMIS PSENEN LAT HEL-S-81p TLE2 ITCH PMC5712622__F3 Akt/mTOR pathway represents a major axis of phosphorylation signal transduction in response to phagocytosis BAD GNB5 PCK1 MYC AKT1S1 BCL2L1 PTEN EIF4E MTOR IRS1 RPTOR RHEB TSC2 RICTOR TSC1 GRB2 CCND1 BCL2 RPS6 EIF4B PMC3474235__F1 The prostaglandin biosynthetic pathway (adapted from ) 15-deoxyΔ12-14-PGJ2 is a metabolite derived from arachidonic acid GSTM1 PMC4900217__F2 Induction of oxidative stress and defense pathways HEL-S-64p HEL-75 NOX4 URAD XDH NOS2 PMC7782450__F3 Amino acid catabolism caused by ARG1 and IDO triggers a shortage of l-arginine and tryptophan, disturbing the homeostasis of host tissues ATF4 EIF2A MTOR ARG1 PMC3474235__F2 Scheme of the various interactions between GSTs and MAPK implicated in stress-signaling pathway (adapted from ) GSTA4 TRAF2 PMC4900217__F6 Metabolic reprogramming for NADPH production HEL-S-49 HPD F2 HEL-S-304 PSPH GCK RPIA RBKS HEL107 RPE PMC5564037__F4 Capturing Human Naïve Pluripotency in the Embryo and in the Dish TCF3 SOX2 LIF TBX3 APC GSK3B LRP5 JARID2 UHRF1 TET2 TET1 TFCP2L1 KLF4 KLF2 SP5 DPPA3 DNMT3L STAT3 PMC8914318__F7 New Vistas in microRNA Regulatory Interactome in Neuropathic Pain IL10 IRAK1 SMAD2 IRAK2 SMAD4 TRAF6 IRAK4 MYD88 MAP3K7IP1 NLRP3 DUSP5 TLR4 CXCR4 GRB2 TXNIP TRAF2 TIRAP PMC7961479__F1 Predominant signaling pathways contributing to melanomagenesis and progression TSC2 MTOR RHEB PMC6801787__F1 Schematic illustration vitamin D synthesis pathway and signalling mechanisms relevant to PAD formation CYP27A1 VIT DBP CYP27B1 PMC7961479__F2 Activating mutations and activation of alternative upstream receptors confer resistance to inhibitors targeting aberrant MAPK signaling TSC2 BRAF RAC1 MTOR RHEB PMC8619854__F3 Promising Role of TGFB Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report FYN TGFBR1 PMC9397497__F6 Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting FOXO3A TBC1D4 MTOR PMC3370605__F1 Roles of N-acetyl-l-glutamate synthase (NAGS) and of its homologous enzyme N-acetyl-l-glutamate kinase (NAGK) in arginine biosynthesis NAGK OTC ARG1 NAGS PMC6691238__F1 Cell apoptosis under ER stress ATF4 EIF2A BCL2 TRAF2 PMC3078503__F4 PIKKs and TCR-associated pathways ATM ATRIP MDM2 ATR H2AX BRCA1 BAX PMC4662426__F5 Difference in expression of the calcium signaling pathway between rat neurons and OPCs grown in vitro PLN BCR CAV3 LCK MCU CAV2 PMC12075545__F6 IFN-Gamma-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy ANGPT2 STAT1 JAK1 FOXO1 PMC4438385__F1 Brown adipose tissue uncoupling and thermogenesis UCP1 TG PMC4332855__F3 Mycobiota: interactions between commensal fungi and the host immune system STAT1 CARD9 DOCK8 S100A9 DKFZp686L24211 IL1B IL12RB1 STAT3 PMC9774157__F6 Maqui Berry and Ginseng Extracts Reduce Cigarette Smoke-Induced Cell Injury in a 3D Bone Co-Culture Model KEAP1 NFATC1 MMP9 PMC4919473__F7 Inhibition of LINE-1 retrotransposition by the SLX4com prevents pro-inflammatory signaling SLX4 EME1 PMC6204284__F2 An illustration of spontaneous DNA double strand break induction and their roles in maintaining the stemness and tumorigenicity of cancer cells CASP3 ATM CAD STAT3 PMC11881714__F2 Normal copper metabolism ATP7B COX17 ATP7A ATOX1 HEL-S-44 COX11 CP CCS PMC11881714__F3 Mechanisms of neuronal damage attributable to Cu toxicity APP HEL-S-44 TNF PMC12095056__F4 Cilia and ciliary signaling contribute to therapeutic resistance SOX2 ATM BCL2 ABCG2 ATR ABCB1 PMC4868425__F8 The GLUD2 genotype effect on mouse metabolome CREBBP HEL-S-304 PMC6148547__F6 MiR-106p-5p in cervical cancer: from expression to molecular mechanism GNG4 GSK3B VEGFA MTOR ITGB1 COMP PMC7376809__F1 An update on stem cell therapy for Asherman syndrome SOX2 SMAD2 APC GSK3B SMAD4 PMC5104320__F4 MinePath: Mining for Phenotype Differential Sub-paths in Molecular Pathways PIK3R5 BTC CDKN1B ERBB3 EGFR GRB2 NRG2 HBEGF NRG1 EIF4EBP1 MTOR AKT3 PMC4579870__F2 Core UPR pathway and its modulation on autophagy TSC2 ULK1 ATF4 EIF2A ULK2 TRAF2 DKFZp686F0183 FOXO1 RHEB PMC4579870__F1 Molecular events in autophagy pathway ATG12 ATG3 UVRAG ATG10 DKFZp686F0183 PMC5807095__F9 Signaling events that are induced by the LH surge and regulate the processes of ovulation and luteinization HEL-S-61p PTGFR PLXND1 RUNX2 EBP APLN NRP1 PRLR CYP11A1 EMCN STAR PMC5807095__F3 Hedgehog signaling pathway components in the ovary HHIP DHH PTCH2 IHH ACTA2 PTCH1 GLI3 SMO CYP17A1 STAR PMC4548949__F3 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus FHIT TH DGAT2 NR3A2 ACACA GDA TPM3 GCK POLE4 LIPG ARG2 LPL DTYMK PHOSPHO1 THBS1 MYL4 DLAT JUN FASN PLB1 OTC DCTD NR1C1 TNC THBS2 PRODH DGKZ ACLY LCT PMC4548949__F4 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus PRKCZ IGF1R PDIA4 GCK ADRB2 DNAJB1 PISD HEL-S-87p IRS1 PS1TP5BP1 HEL-S-61p DCN MMP2 CPT1A LIPG PHOSPHO1 FGF19 THBS1 CYP17A1 JUN PTDSS2 HK2 CYP2A13 APOE PMC4846903__F5 ErbB4 signal pathway EGF ECD PGR EGFR GFAP ERBB3 NRG1 WWP1 S100B ADAM17 NEDD4 PI3 ERBB4 CSN2 SOS1 SHC1 WWOX ITCH PMC3784453__F10 Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo LPL PGC TG SIRT1 UCP2 PMC11068999__F4 Hh signaling pathway APC RB1 PMC9268899__F1 Astrocytes in Neurodegeneration: Inspiration From Genetics SNCA LRRK2 PARK2 MMP9 MTOR APOE PMC11068999__F2 Wnt/Beta-catenin pathway APC RB1 PMC11670693__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905681 ZNRF3 RNF43 LRP5 LRP6 TCF4 PMC7961479__F3 MAPK, PI3K, and angiogenic reactivation confers resistance to c-KIT and VEGFR TKIs TSC2 MTOR RHEB PMC9581055__F10 Identification of Biomarkers Controlling Cell Fate In Blood Cell Development FLI1 RUNX2 NFATC1 ERG SMAD6 tal-1 TNLG7A CDKN1C SOX9 CDKN2B GJA1 SP1 JUN GATA3 BAX PMC7664111__F7 Graphical rendering of GRP78-dependent CRIPTO signaling driving stem-like tumor cell phenotypes NODAL CRIPTO SMAD2 SRC PMC12035885__F2 Crucial environmental factors associated with NK cell function in the TME of breast cancer IL2RA HDAC1 IFNG STAT3 HEL-S-281 PMC12035885__F3 Main metabolites in the TME of breast cancer that affect NK cell function HLA-G MICB FTH1 MICA IFNG PMC4557010__F7 Schematic models for JAK/STAT cell signaling pathway and the inhibitory actions for JAK/STAT target anticancer drugs EGF LIF SRC MTOR TF PMC6855049__F6 Antifracture pathways of potential targets for treating fracture from main active ingredients of Drynariae Rhizoma ATF2 GSK3B MYC GRB2 APP SRC TRAF6 JUND RAF1 TNF CDC42 RXRA PMC5069086__F6 Schematic model for HCV-induced CD4+ T cell senescence regulated by the ΔNp63–miR-181a–Sirt1 and ΔNp63–miR181a–DUSP6 signaling pathways SIRT1 FOXP3 PMC4939511__F2 Signal pathways of migration inhibitory factor (MIF) CD44 CD74 JUN PMC10149936__F14 Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth SRC PAK4 RHO RAC1 PMC7015662__F1 AIM2 inflammasome activation IRF9 GBP5 AIM2 GSDMD PIF1 PMC7120363__F2 Autophagy is involved in the regulation of the normal function of the intestinal mucosa and the pathogenesis of enteritis ATG16L1 IRGM CGA XBP1 DKFZp686F0183 PMC3192861__F10 A schematic model of GC-mediated acute activation of NHE3 via SGK3 GCGR SGK2 GC SGK1 PMC7301251__F3 Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology BRAF PGR KRT19 EGFR MYC MAOA PTEN ACHE PARG MTOR MMP2 ELANE ABCG2 BCHE JUN BAX FGF2 APC VHL VEGFA TNF HRAS RXRA MMP14 ABAT ERBB2 BCL2 HEL113 IL-21 TERT PMC9528770__F2 Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders TRADD MTOR TRAF2 FADD PMC12045570__F2 Ferroptosis related signaling pathway affected by EBV, HTLV-I and KSHV viruses LIPT2 GPX4 FANCD2 SLC7A11 DPP4 ATF3 POR SIRT3 ELAVL1 CDKN1A SLC3A2 SLC40A1 DHODH PMC4862632__F1 Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro CASP3 EGF TLR4 TRADD MMP9 RELA EGFR CRP MYD88 TRAF2 CASP8 STAT3 PMC8881509__F7 Extracellular circulating miRNAs as stress-related signature to search and rescue dogs PERP ATM MYC ATR RFWD2 PMC7271281__F4 The ncRNA pivot regulator on the dysfunction module MISP PMC2897923__F1 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression COX2 APC GSK3A CCND1 TCF4 PMC6721308__F2 Distribution of the genes significantly modulated in the Alzheimer’s disease pathway BACE1 APAF1 PSEN2 RTN4 APP ADAM17 PMC2897923__F2 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression ROCK2 HEL-S-62p ARHA RAC1 CTHRC1 PMC9380335__F6 Impact of fetal exposure to mycotoxins on longissimus muscle fiber hypertrophy and miRNA profile ME1 TSC2 BAD CD37 BCR MDM2 GRB2 SYK RAC1 RBL2 CD19 PMC2897923__F3 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression KISS1 CD44 ROR2 STAT3 PMC3205325__F2 Canonical TGFB signaling; Smad-dependent pathway downstream of TGFB receptors SMAD2 SMAD4 PMC4047858__F7 Combined metabolomics–transcriptomics identification of pathways affected by MPP+ CTH PSAT1 DHFR TYMS PSPH HEL-S-51e MTHFD2 PHGDH ROS1 PMC3477860__F4 Schematic diagrams of the role of STAT1 in antimycobacterial, antiviral and antifungal immunity IL21R STAT2 IRF8 IRF9 TRAF3 IRF3 IL23R IL17RC IL12RB1 TLR3 STAT1 CARD9 CD40 TYK2 JAK1 IRF-1 STAT3 PMC7252450__F4 Advances in circular RNAs and their role in glioma (Review) NOVA2 HOXB7 MMP9 EGFR TCF2 SOX4 PI3 IGF2BP3 CFH CDK2 FZD7 CDK4 NT5E STAT3 PMC6519821__F7 Proposed molecular mechanism of the anti-esophageal cancer activity of Rk3 CASP3 BAD CASP9 CCND1 CDK4 MTOR DKFZp686F0183 BAX PMC7461358__F10 MiR-199a-3p and miR-199a-5p might affect MAPK signaling pathway by regulating DUSP5 and MAP3K11 PLAT MAX ACVR2A UNG PARVA PMC5137819__F1 Phosphatidylinositol‐3 kinase (PI3K)–AKT PI3K‐AKT pathway is activated upstream by ligand binding to a growth factor receptor, in this case a receptor tyrosine kinase (RTK) BAD FOXO4 PDK2 MDM2 PTEN MTOR FOXO1 PMC8250149__F2 NLRC5: A Potential Target for Central Nervous System Disorders LTA CYLD TRAF3 ATF1 TRAF6 TRIM25 PMC6820523__F9 Our proposed model of nsDNA-induced APOL1 expression through engagement of the cGAS/IFI16-STING pathway in human immortalized AB8/13 podocytes TBK1 STAT1 CGAS IRF3 TYK2 JAK1 APOL1 IFI16 PMC4031758__F2 Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC9333241__F8 Mapping of gene expression change on Na/K-ATPase/Src signaling pathway SPR FYN SOST CYC1 CRK SHC3 CYCS PMC9465375__F4 Roxadustat: Not just for anemia BCL2 TXN PMC6324838__F1 Overview schematic of the proposed relationship of inhalant organic dust exposures induction of bone loss CXCL1 TLR4 MYD88 NOD2 PMC6770051__F5 miRNA-responsive biological pathways and the presence or absence of interactions between its genes and the transfected miRNA UBE2G2 CASP12 OS9 LACRT SVIP SKP1 GIP RHO RBX1 ID1 CRK RGS14 UBC HEL-S-11 DOCK4 EIF2A PKD1 CAD UFD1L LAT VAV2 CDC42 PMC2663984__F5 Expanded canonical Wnt/GSK3 signaling pathway APC LRP5 LRP6 PMC5263152__F1 Canonical and non-canonical NLRP3 inflammasome activation NLRP3 HMGB1 TLR4 IRF3 IFNAR2 TNF PMC12210545__F3 Complement system and the role of HCQ HEL-S-62p PMC8250149__F3 NLRC5: A Potential Target for Central Nervous System Disorders VEGFA CCND1 PMC3031501__F8 Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells TSC2 CDK2 GSK3B MTOR SKP2 PMC4820338__F1 Schematic model of RIP1-mediated regulation of the PI3K-Akt pathway TSC2 TSC1 PTEN MTOR IRS1 RHEB PMC5034700__F1 Proposed metabolic pathway of lapatinib CYP3A4 PMC9169033__F4 Metabolic adaptations in MS GLS PMC7791185__F9 NLRP3 Inflammasome Activation and Pyroptosis in Lactate‐stimulated Human NP Cells NLRP3 ASIC3 GSDMD PMC8326261__F3 Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility CXCL1 USF1 TLR9 USF2 ATF2 MYD88 TNF CCL3 PMC5520506__F1 PI3K/Akt signalling and its activation in cancer IGF1 PTEN AKT3 PMC7849620__F4 Mechanisms of abnormal coagulation and hepatic ischemia/hypoxia reperfusion injury in COVID-19-associated liver injury CCR2 TLR7 TLR4 CXCL10 CXCL8 VWF CCL2 IL1B PMC3355838__F3 Wnt signaling pathways NLK APC LRP5 UNK LRP6 ARHA PMC3355838__F1 Step model of thyroid carcinogenesis BRAF TSHR PTEN PMC3355838__F2 Genetic events involved in thyroid tumor initiation and progression BRAF TSHR PTEN PMC12154509__F4 SIRS signaling: inflammatory pathways during shock and cytokine storm and the production of soluble cytokine receptor antagonists TRAF6 IRAK4 MYD88 PMC10969160__F1 Summary of potential therapeutic targets EGF SOX2 SMYD3 APC LRP5 CD44 LRP6 BMI1 MTOR MMP7 SUFU SMO HOXA5 PMC11866803__F10 Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer ROCK2 DAAM1 AGO2 ARHA FGF9 PMC12192441__F1 Signaling pathways of activins and other TGFB related ligands in adipocytes BMPR2 ACVR2B ACVR2A SMAD2 SMAD4 SMAD1 TF DKFZp781O1323 GDF3 PMC6580686__F1 miRNAs regulating the conserved pathways of aging in skeletal muscle SIRT1 TERT PMC4454460__F5 A model showing different pathways to repair replication fork damage due to structure-forming sequences RAD52 RAD51 PMC4436567__F2 Effectors interfering with SA-dependent signaling and gene regulation MED19 PMC7398379__F5 Proposed model of the transgelin mechanisms involved in promoting colon cancer metastasis NCKIPSD WIPF1 PARP1 WAS RHO RAC1 CALM1 PMC6321180__F3 Wnt1/Beta-catenin signaling as a key player in glia–neuron cross-talk IL16 WNT1 GSK3B PMC6321180__F1 Canonical Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) pathway and non-canonical Wnt/Ca2+ and Wnt/planar cell polarity (PCP) pathways [,,,,,] APC GSK3B LRP5 ARHA RYK ROR2 CDC42 PMC6321180__F2 Wnt1/Beta-catenin signaling regulation of midbrain dopaminergic (mDAergic) neuron survival/death according to our published findings [,,,,,,,,] LEF1 APC GSK3B LRP5 LRP6 GPR49 PMC7530130__F28 Enzymatic Noncovalent Synthesis RIPK1 TNF MLKL PMC7904711__F1 Shh pathway GLI3 SHH SMO PMC10150162__F9 Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases CCR2 RALA PTEN CCL2 PMC9121315__F9 Hepatic pannexin‐1 mediates ST2+ regulatory T cells promoting resolution of inflammation in lipopolysaccharide‐induced endotoxemia NLRP3 TLR4 IL33 PANX1 PMC5732537__F8 Virus-induced endoplasmic reticulum (ER) stress and the consequent downregulation of the stimulator of interferon genes (STING) pathway in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) TBK1 CGAS RNF5 IRF3 PMC9037064__F3 Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells NOTCH2 BAMBI STAT1 BMP2 SMAD2 MAPK14 SMAD4 JAK1 FAT1 TCF4 STAT3 PMC4233036__F2 Pathway analysis highlights opposing regulation of a DNA repair pathway in radioresistant versus radiosensitive cells ATM MDC1 ATR IFNG PMC6610339__F1 Release of mitochondrial proteins and mtDNA initiates an inflammatory response in CICD NLRP3 CGAS TLR9 IRF3 BAX PMC9039039__F7 Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy TOB1 PZP CBL PMC2830572__F1 TNF A inhibits erythropoiesis by direct and indirect effects EPOR EPO HIF1A GATA2 PMC2811741__F7 Mast Cells Mobilize Myeloid-Derived Suppressor Cells and Treg Cells in Tumor Microenvironment via IL-17 Pathway in Murine Hepatocarcinoma Model MMP9 CCL2 CCL22 PMC7764352__F7 STRING: AML associated enriched pathways among the top 94 identified drug targets USP4 POLE SOST TFRC RPSA PMC7840718__F3 Wnt growth factor triggers macropinocytosis by binding to co-receptors Frizzled (Fz) and LDL receptor-related protein 6 (Lrp6) on the cell surface PRMT1 PAK1 APC GSK3B LRP6 PMC11118937__F1 Nrf2 signaling in mitigating heat stress and xenobiotic-induced oxidative distress and apoptosis KEAP1 PMC8751739__F8 Suppressive effects of dental pulp stem cells and its conditioned medium on development and migration of colorectal cancer cells through MAPKinase pathways BCL2 BAX PMC7644630__F2 TBK1 and Innate Immune Signaling TBK1 CGAS RIPK1 TANK TLR4 RELA IRF3 MYD88 OPTN TLR3 MAVS PMC7840718__F1 Cancer cells ingesting extracellular small particles, such as protein, necrotic debris, and ATP, through macropinocytosis PAK1 EGFR PTEN RAC1 MTOR CDC42 PMC7840718__F2 Growth factors stimulation induces the PI3K/Akt/mTORC1 pathway TSC2 TSC1 RHEB PMC4400645__F1 PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through Beta-Catenin Signaling WNT9B FAT4 PMC6008200__F7 Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research PLCG1 BAD MAP2 NGF HEL2 GSK3B TRAF6 PLCG2 CRKL PDPK1 FRS2 ATF4 BAX SORT1 MAPKAPK2 MAP3K1 FOXO3A PSEN2 MAPK7 ZNF274 MAP2K5 CALML4 ARHA RAC1 SH2B2 CRK CALML6 NTF3 NFKBIA NFKBIB PSEN1 GRB2 CALML3 BDNF NFKBIE CDC42 PMC2858667__F1 Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons CA3 PMC8192250__F1 Mechanisms linking gut microbial metabolites to insulin resistance PRDM16 PCK1 IRS1 TRPV1 PMC9362167__F4 Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective NLRP3 MTOR STAT3 PMC3138544__F1 Targets and therapies for B-cell non-Hodgkin's lymphoma (B-NHL) within the context of the 10 hallmarks of cancer and overlapping oncogenic signaling pathways BTK LYN CSA2 MTOR RHEB PMC9248984__F3 Targets for limiting DC maturation / activation TNLG8A CCR7 CD40 CD80 SGK1 PMC4254517__F2 Anti- and pro-apoptotic roles of RIPK1(A) Upon TNFR-1 ligation RIPK1 TRADD RIPK3 TRAF2 CASP8 FADD MLKL PMC7069528__F1 Effect of cannabidiol (CBD) in Parkinson's disease and Alzheimer' disease (AD) GFAP APP FAAH S100B IL1B TRPV1 PMC3295030__F1 Simplified description of the insulin/IGF-1 signal transduction (IIS) pathway in invertebrates and mammals IRS4 FOXO4 GRB2 PTEN FOXO6 IRS1 AKT3 PMC2896944__F3 Hsp90 shelters aberrant neuronal proteins PINK1 LRRK2 GSK3B PMC5709276__F1 Pathway alterations in glioblastoma multiforme NF1 BRAF CDKN2B DKFZp781B1423 EGFR MDM2 CDK4 PTEN MTOR CDKN2A CDK6 PMC10860821__F3 OA is a condition that involves the breakdown of cartilage in the joints NLRP3 ADAMTS5 IL1B PMC10860821__F1 Three types of pyroptosis pathway NLRP3 RIPK1 TLR4 CMPK2 MYD88 GSDMD PMC5836578__F5 Bioinformatic analysis of ATP-binding cassette subfamily A member 1 (ABCA1), revealing its preventive role in carotid plaque rupture and atherosclerosis progression during the inflammatory reaction TBL1X RXRG NCOA1 ABCA1 NR1H3 NR1C1 FABP1 RXRA NR1H2 PMC7290603__F3 Impact of tumor-derived EVs in Cancer Therapy Resistance TP53INP1 HEL-S-22 PMC123677__F3 The action of S-phase checkpoints in the suppression of spontaneous genome instability RFC2 DDC DRC1 MRE11A PCNA RFC3 RFC4 PMC4553792__F3 Inactivation of DPH5 induces NFKB and death receptor pathways EGF CREB1 TNF IFNG STAT1 IKBKB NFKBIA CREBBP EP300 NFKB1 RELA SP1 JUN IRF-1 IL1B STAT3 PMC6478864__F1 Wee1 inactivates Cdk1 by phosphorylation at tyrosine 15 WEE1 RRM2 CCNB1 CDC2 PMC7064006__F13 Possible metabolic pathway maps associated with the lipid biomarkers in dampness-heat induced diarrhea and dampness-heat induced diarrhea with PD treatment PC PGP LASS1 LPA PMC7503462__F1 Schematic description of tryptophan metabolic pathways with assigned physiological roles and regulatory points of select metabolites ASMT KYNU KMO IDO2 IL1B PMC8924449__F9 Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress MAP2K1 ELF3 HPD PRODH XDH PRR7 PMC3557440__F4 Schematic overview of the homologous recombination (HR) pathway RAD50 RAD51 MRE11A PMC9169637__F7 Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion CXCR4 PTEN MTOR OCM PMC11430608__F1 Mechanism of development of AP IL6 TNF STAT3 PMC7353012__F3 Functions of UCA1, lincRNA-ROR, and lncRNA MIR2052HG in the tamoxifen resistance of breast cancer EZH2 MTOR LMTK3 DUSP7 PMC12000292__F4 ANXA2 inhibits tumour cell apoptosis and its effects on tumour immunity NLRP3 ULK1 ANXA2 FADD PMC7353012__F4 Functions of GAS5, DSCAM-AS1, and Eleanors in the tamoxifen resistance of breast cancer PTEN PMC4069315__F1 Mechanisms of action of lactic acid bacteria via extrinsic and intrinsic pathways of apoptosis BAK1 TNF PMC3384717__F9 Androgens up-regulating PCa cell proliferation via p66Shc-ROS signal pathway ERBB2 GPX1 PMC4069315__F2 Immune responses induced by lactic acid bacteria LTA IL16 PMC6893972__F7 Neuronal molecular pathways indicate glutamate and dopamine receptor signaling, in a representation of 45-day cerebral organoid proteomes TH PSD GLS PMC7747855__F7 Astrocytic SHH signaling pathway regulates BBB integrity after ICH SHH SMO PMC7356355__F1 Intoxification Pathway EGF IL2 PMC8844822__F1 SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites NAMPT NMNAT2 SARM1 PMC9446157__F2 Calcium signaling in cancer metastasis to bone TRPC1 IGF1R TRPV2 IGFBP1 SRC TRPV6 NFATC3 TRPM7 STIM1 HEL-S-43 PMC8127498__F8 Tissue-specific transcriptome analyses reveal candidate genes for stilbene, flavonoid and anthraquinone biosynthesis in the medicinal plant Polygonum cuspidatum PMVK MVD MVK PMC6001756__F1 Estrogen receptor (ER) signalling pathway ERBB2 EGFR MYC SRC SP1 TF PMC12000292__F2 ANXA2-induced autophagy inhibits apoptosis in tumour cells ULK1 TFEB S100A10 ANXA2 STAT3 PMC3310197__F7 Interactions of signaling by ER stress, oxidative stress, and cytokines with the pathways of autophagy: Induction of autophagy requires the assembly of Beclin-1 with class III PI 3 kinase (Vps34) and UVRAG ATG12 ATG3 UVRAG ATG10 MTOR PMC4826689__F1 Canonical Wnt signaling pathway (Beta-catenin-dependent Wnt signaling pathway) APC GSK3B AXIN1 LRP5 LRP6 DKK1 PMC4826689__F2 Noncanonical Wnt signaling pathway (Beta-catenin-independent Wnt signaling pathway) NLK APC PMC4613338__F1 Glutamine metabolism and potent targets for cancer therapy SLC7A5 SLC7A11 MYC MTOR PMC5402045__F2 ST2/IL-33 signaling pathway TLR9 IRAK1 IL33 TRAF6 MYD88 IRF-1 GATA3 FOXP3 PMC9107211__F3 Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study GSK3B CD81 BTK CD72 BCL10 RASGRP3 BCR BASH GC CD22 LYN GRB2 SYK CD19 PMC5927707__F2 Involvement of ZMYND8 and demethylases in the DDR and cancer ME1 KDM5C KDM5A ZMYND8 GATAD2A PMC11813773__F2 Dual roles of SBAs in colon cells: anticancer and cancer-promoting effects EBP DKFZp781B1423 EGFR MDM2 PMC11813773__F3 Anticancer effects of SBAs in Hepatocellular Carcinoma (HCC) and Pancreatic Cancer NDRG2 STAT3 BAX PMC8152700__F5 Cardiac fibrosis COL3A1 POSTN APC GSK3B LRP5 LRP6 COL1A1 PMC7352479__F3 Crosstalk among glycolysis, MAPK, and PI3K pathways BAD MDM2 PFKL PTEN HEL-S-133P BAX HEL-S-162eP PMC7352479__F1 Glucose metabolism GPC3 FBP1 PFKL HIF1A HEL-S-133P HK2 HEL-S-162eP PMC7352479__F2 Oxidative stress pathways MAF TSC2 TSC1 KEAP1 PTEN MTOR RHEB PMC3017081__F4 Cell cycle G1/S check point subnetwork TGIF2 CDKN2D GSK3B SMAD4 RB1 CDKN2A TFDP1 CDK6 CCNE1 NPAT ATM CCND1 CDK4 CDC2 UHRF2 HDAC1 IFI27 CKS1B PLAGL1 CDKN1A CDKN2B CDK2 GRB2 ATR TGFB1 SKP2 PMC5330121__F6 The interactive pathways of stress-responsive miRNAs and their targets MYB SPX NFYA PMC3017081__F3 Crosstalk between interleukin signalling pathways IL7 IL3 IL2 IL6 IL4 IL5 PMC6456508__F8 TLR4/NFKB pathway mediating miR-625-5p and COL1A1 in IDD pathogenesis BTK TLR4 IL6 MYD88 COL1A1 IL1B TIRAP PMC11430608__F3 Activated intracellular signaling pathways in acute pancreatitis and their inhibition by natural compounds TLR4 KEAP1 MYD88 MLKL STAT3 PMC9505822__F1 Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer IMPACT SSB TDP1 PMC9599866__F3 Targeting KRAS in PDAC: A New Way to Cure It? EGFR MTOR AURKA PMC4513356__F1 Wnt Signaling in Dendritic Cells: Its Role in Regulation of Immunity and Tolerance FOXP3 PMC7705326__F1 Mechanism of action of possible anti-SARS-CoV-2 drugs on the interferon signaling pathway TBK1 TLR9 STAT2 IRF7 IRF9 TRAF3 IRF3 MYD88 MTOR TLR3 IFNG STAT1 STAT4 TYK2 JAK1 MCL1 IRF-1 STAT3 PMC4163504__F1 Proposed molecular interaction between two neuropathologies such as major depressive disorder and Alzheimer’s disease APP CA3 APOE PMC3085438__F5 Working model for the role of CCN6 in breast cancer invasion WISP3 IGF1R IGF1 IRS1 PMC7999260__F3 Combination therapy for miR-21i and TMZ BCL2 PTEN STAT3 PMC7999260__F4 General principle of the HSV-TK suicide gene system ATM TNF FADD PMC7593559__F2 AAI can activate TGFB/Smad-independent signaling pathways to cause abnormal cell proliferation IL18 SMAD2 EGFR TGFBR1 GRB2 TGFBR2 SMAD4 BCL2 CYP1A1 CYP1A2 PMC3757404__F1 Wnt/Beta-catenin Signaling Pathway APC SOST LRP5 LRP6 PMC3390257__F2 mTOR: from growth signal integration to cancer, diabetes and ageing TSC2 TSC1 GSK3B YY1 SESN1 PTEN SESN2 EIF4B IRS1 RHEB PMC9338659__F4 Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma EGF EGFR CCND1 MTOR DKFZp686F0183 STAT3 BAX PMC11520425__F1 Classic Wnt/Beta-catenin signaling pathway: mechanisms in closed and open states APC LRP5 LRP6 PMC11520425__F2 Wnt signalling regulation of osteoblasts and osteoclasts MCC PKN3 LRP5 SRC LRP6 ARHA ROR2 RHO PMC11575928__F2 Survival mechanisms of ovarian cancer spheroids in ascites HGF TWIST1 FZD7 NOTCH3 COL4A2 PMC11575928__F3 TAMs in spheroid formation, survival and metastasis CCR5 EGF CD47 UBR5 POSTN GPT MMP9 EGFR HBEGF VEGFC SIRPA CD163 CCL18 ARG1 CD24 PMC1600679__F7 Summary of changes in the Wnt/Beta-catenin pathway in pancreatic adenocarcinoma APC GSK3B FZD2 PMC9252752__F7 Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway NLRP3 IL16 TLR4 TRAF6 MYD88 PMC2760938__F13 Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase CD, Lyn Kinase, and Matrix Metalloproteinases EGFR LYN HBEGF LPA PMC3395887__F3 Interaction of pathogen recognition and ST2 receptor systems with FcERI leads to substantial enhancement of production of cytokines and chemokines TLR4 ATF2 IL33 TRAF6 IRAK4 MYD88 TLR3 PMC3348998__F1 Lipids and Prostate Cancer ME1 HEL-S-26 SCD ACACA ACLY HEL60 HMGCR HK2 FASN PMC10473156__F3 DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease BLM RAD50 RAD51 ATR MRE11A DNA2 PMC5398881__F6 Scheme showing hyperglycemia-induced VEGF expression regulated by PRR, RAC1, and miRNA signaling SPRY1 PTEN RAC1 HIF1A PMC3035994__F1 Simplified model of nutrient signaling pathways influencing metabolic responses TSC2 TSC1 PTEN RHEB PMC5891886__F3 Epithelial proteomic networks for TRIM28 high (a) and low (b) ratio cases RUNX1 LCK EGFR TRIM28 SPHK1 MTOR BAX PMC7562735__F10 Distribution of targets of KGEC on the comprehensive signaling pathway BAD TRADD MMP9 LCN2 TNF MTOR MMP3 COX2 SGK2 TLR4 BCR VCAM1 BIK GRB2 IL2 BCL2 SYK CDK4 TRAF2 FADD SGK1 LAT PMC4905361__F2 TNFR1 signaling CAP2 RIPK1 CAP1 TRADD CYLD SHARPIN TNF TAB3 PMC8086570__F5 Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses TWIST2 NCALD TRIM9 MBD6 WDR4 ZEB2 GSC TRIM39 PMC7504541__F9 Hypothetical role of IL-6 in oncogenesis and tumor-associated thrombocytosis TPO ADAM17 STAT3 PMC419721__F7 Schematic model of signaling events to MEKs and Erks induced by threshold concentrations of Epo EPOR EPO GSK3B GSK3A PMC5746087__F7 miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis TSC2 BAD TSC1 HEL-S-28 MDM2 GRB2 CCND1 CDC37 PTEN EIF4E MTOR RHEB PMC7915065__F1 Signaling pathways and factors involved in programmed cell death ligand-1(PD-L1)-induced resistance YAP1 EGFR STAT3 PMC7915065__F2 Key mechanisms underlying resistance to PD-L1 (1) NLRP3 HHLA2 IL8RB YY1 CD80 JAK1 LAG3 PMC4744516__F1 Long noncoding RNAs in viral infections ISG15 IFITM3 BST2 EIF2A IRF3 TRIM25 MAVS IFITM1 PMC4050248__F7 Protein kinase C epsilon (PKCɛ) is a major regulator of mitochondrial nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide adenine dinucleotide (NAD) NAMPT NMNAT3 HIF1A PMC6537414__F6 Functional analyses of five core clusters PIK3R1 SOCS3 CSF3R MYC BCL2L1 MTOR PIM1 GHR PTPN11 PTPN6 IL2RB GFAP HRAS EP300 CDKN1A CISH IL2RG PRLR PIAS1 GRB2 BCL2 IL6ST JAK1 MCL1 RAF1 STAT3 PMC10458946__F6 STING signaling pathway inhibition by STINGB in various ways and at various steps TBK1 CGAS PMC11452178__F9 The regulation of muscle phenotypes by MSTNDel73C mutation with FGF5 knockout FOSL1 MYMX MYMK MSTN MYOD1 PMC3475613__F2 Schematic illustrating metabolic pathways prominent in malignant cells HEL-S-26 MAX FH MPC1 MYC MPC2 HEL-S-133P HK2 PMC9640569__F6 Genomic control of inflammation in experimental atopic dermatitis IL33 VEGFA TSLP PMC9526899__F3 Omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows MLXIPL MGLL DAGLA IL6 TG HEL-S-104 FASN PMC7673069__F1 Schematic presentation of the life cycle of SARS-CoV-2 in the host cell and proposed sites of famotidine action ACE2 TMPRSS2 HEL-S-69p PMC9376585__F5 Pyroptosis in inflammation and cancer IL10 NLRP3 IL18 P2RX7 CARD8 GSDMD DFNA5 PMC4107230__F6 Different mechanisms of signaling for EMT which might be induced by FGF10 TIMP1 CDK2 APC FGF10 GSK3B CDH2 MTOR PMC7814631__F6 Cell signaling pathways in the epigenetic regulation of myogenesis CARM1 IGF1 MYF5 ACTN1 PAX7 YY1 EZH2 MYOG PMC7967207__F1 Tannic acid (TA) acts as a repressor for multiple proteins essential in several oncological signaling pathways EGF SOX2 SMAD2 LIF EGFR TGFBR1 SMAD4 STAT3 PMC7945216__F7 Mechanism graph of the regulatory network and function of FoxM1-mediated miR-335-3p in NSC self-renewal FOXM1 CDK2 CDK4 FMR1 PMC2259464__F2 TGFB signaling pathway SMAD2 SMAD4 PMC8750186__F4 mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells PSMB6 PSMD13 E2F4 FH PSMB3 TFDP2 RB1 TFDP1 E2F3 PMC5885760__F2 Microbiome series CUTC PMC8044581__F10 MicroRNA-1297 suppressed the Akt/GSK3B signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model GSK3B PTEN BAX PMC5531511__F3 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort NLK ATM CDK2 HEL-S-11 MDM2 INS KLF2 BNIP3 SKP2 INSR PMC7878388__F1 HSV manipulations on the cytosolic pattern recognition receptors TBK1 CGAS AIM2 MAVS IFI16 PMC5531511__F4 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort AFP PATJ APC PMC4800863__F5 Schematic illustrations of l- and d-proline metabolism in Sinorhizobium meliloti PROC PROB1 PMC2704572__F1 Complement effectors generated during activation contribute to various mechanisms that limit tumor growth HEL-S-62p C4B_2 MASP1 MASP2 C4A PMC7884467__F1 NLRP3 inflammasome pathway NLRP3 KL PTMS FADD GSDMD PMC2704572__F2 Some complement proteins can accelerate tumor growth C4B_2 MASP1 FH MASP2 C4A PMC6434430__F2 ERK signaling pathway was hyperactivated in the patient’s tumor tissue KIT DDR1 BAD PDGFRA FOS NTRK1 EGFR MYC ATF1 RET CSF1R RAP1A ZAP70 GRB2 JUN LAT PMC5384838__F1 Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome ChAT ALG2 MUSK COLQ LRP4 DPAGT1 ALG14 ACHE SCN4A GFPT1 PMC4709758__F9 Signaling pathways of IL-17A in synovial fibroblasts TRADD TRAF5 IRAK1 RELA TRAF6 MYD88 TNF TRAF2 PMC9483202__F3 Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases KEAP1 GSK3B PTEN SIRT1 UCP2 PMC6295097__F7 Proposed pathway of anti-tumor effects of propofol on lung cancer A549 cells MTOR PMC3712618__F4 Putative PGC-1-mediated mechanism of cancer-induced skeletal muscle wasting IGF1 MTOR IRS1 PMC4735260__F6 Transcriptional regulation of mitophagy ATF4 FUNDC1 SP1 BNIP3 CITED2 PMC6193900__F1 Signaling pathways and regulatory nodes that indicate novel therapeutic approaches for KRAS mutant NSCLC TBK1 KEAP1 YAP1 ERBB3 RAC1 CDCP1 HES1 PAK1 FGFR1 ECT2 WEE1 FRS2 SRC FSTL5 STAT3 PMC9170780__F4 Bone pain: Progress in research from bench to bedside MSC ARHA DCC PMC6508148__F3 Proposed models of CST1 participating in the signaling pathways.Notes: CST1 was involved in GSK3, AKT, and IL-6 pathways GSK3B CST1 PMC8106556__F1 Targeting the alternative bile acid synthetic pathway for metabolic diseases CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 CYP7A1 PMC8106556__F2 Targeting the alternative bile acid synthetic pathway for metabolic diseases CYP27A1 CYP8B1 ABCG8 ABCG5 AKR1D1 CYP7B1 ABCA1 CYP7A1 PMC3978875__F6 Proposed signalling interactions between C-type natriuretic peptide (CNP) and mechanical loading in chondrocytes NPR2 NPR3 CSK CNP IL1B PMC11781175__F8 AS III induces autophagy and activates the nuclear translocation of Nrf2, resulting in the accumulation of p62 and autophagic flux blockade MAF KEAP1 YAP1 PMC7453787__F2 BMP-SMAD pathway and hepcidin regulation in different iron states BMP6 BMPR2 HAMP ACVR2A BMP2 TMPRSS6 HFE FURIN TFR2 PMC7453787__F4 Crosstalk between inflammation and the BMP-SMAD pathway in hepcidin regulation BMP6 BMPR2 HAMP ACVR2B ACVR2A BMP2 STAT3 PMC6354897__F1 Key pathways interacting with theMEP pathway in chloroplast CS PMC7918730__F3 Clock and mTOR pathway interconnection TSC2 MTOR PMC4750108__F1 Working model of the innate immune sensing of tumors leading to spontaneous T cell responses in vivo TBK1 CGAS IRF3 PMC11117976__F3 NETosis in neutrophils IL8RB TXNIP PMC11117976__F5 M2 macrophage polarization MPO HEL-S-44 ARG1 IRF4 PRX PMC11117976__F1 TLR and NOD receptor-mediated immune response NLRP3 NOD1 TRAF6 TXNIP RIPK2 MAP3K7IP1 NOD2 PMC7005297__F1 Wnt/Beta-catenin pathway in cancer stem cells SMYD3 APC GSK3B LRP5 MYC CD44 LRP6 GPR49 DKK2 PMP22 TIAM1 MMP7 TEF EZH2 HOXA5 DACT1 TERT PMC7005297__F2 Hedgehog signaling pathway in cancer stem cells PRKCI RUNX3 CD44 BMI1 USP48 BCL6 FOXC1 TWIST1 SUFU PTCH1 SHH CCND1 SMO FBXL17 GALNT1 PMC8508937__F3 ERB Regulation of Gonadotropin Responses during Folliculogenesis FSHR LHCGR APPL1 PMC7005297__F3 Targeting cancer stem cell pathways for cancer therapy CCR7 CD44 TNFRSF19 CD40 BMI1 FOXP3 PMC3986830__F1 DREAM complex: Master coordinator of cell cycle dependent gene expression FOXM1 CDK2 CDK4 LATS1 LATS2 FBXW7 DYRK1A PMC11117976__F8 Immune suppression during bacterial infection NLRP3 TXNIP CA12 PRX PMC7177584__F3 PRDM proteins participation in signal transduction pathways, proliferation, and gene expression regulation PRDM5 CEBPE INCA1 PRDM14 ADAMTS12 PRDM16 PRDM13 PRDM11 FOS SMAD2 APC GSK3B DKK1 MTOR IRS1 SKI JUN SERPINB2 PRDM8 PMC6095988__F2 Androgen signaling pathway in granulosa cells of the primordial follicle SHBG TBP HEL-S-99n SRC NCOA1 SRY PMC7177584__F1 PRDM proteins contribution in the mechanisms related to invasiveness and metastasis PAK1 PRDM14 FYN PRDM13 TIMP1 MMP2 ARHGAP30 ERBB2 PRDM2 BMP5 RELB PMC3707302__F3 Immunological synapse: the gateway to the HIV reservoir NUMB ADAM10 ADAM17 PMC5427056__F1 Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy NF1 ULK1 TSC1 HP PTEN EIF4E DEPTOR EIF4B IRS1 SGK1 FOXO1 RHEB PMC5464113__F2 Genes found to modulate the accumulation and secretion of different aggregated species of aSyn RAB11A RAB27A RAB8B RAB13 PMC8725311__F2 Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier BAD MYC JUN PMC5688955__F1 Diagram showing the various effects as well as the different pathways activated by ouabain in ADPKD cells EGFR SRC CFTR BAX PMC6221947__F1 Polyamine Pathway and Reaction Mechanism of DHS EIF5A DAP DOHH PMC8630681__F8 Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway FER GPX4 SLC3A2 HMOX1 TF PMC4016715__F2 Ciliary-vesicle-dependent steps of ciliogenesis, and modular organization and mechanism of the IFT machinery RAB14 TPR BBS1 IFT140 IFT172 IFT80 IFT52 IFT22 IFT43 IFT46 RAB15 RAB12 BBS9 IFT74 BBS7 IFT57 BBS5 BBS4 IFT25 IFT81 IFT20 PMC4016715__F3 Model depicting ciliary cargo trafficking pathways PCM1 BBS4 ARF4 RP2 ARL6 ARL3 NPHP3 UNC119 CEP290 RPGR IFT20 PMC9376585__F1 Pyroptosis in inflammation and cancer NLRP3 NLRC4 NLRP1 AIM2 GSDMD PMC9376585__F2 Pyroptosis in inflammation and cancer PLCG1 CGAS GPX4 IRF7 NLRP1 PLK4 DDX3X EIF2AK2 DPP9 NLRP3 PINK1 CARD8 ELANE IL1B PMC6696194__F8 Signaling pathway for GSSA via SCARB1 receptor from CD19+ lymphocyte BCR BASH LYN SYK PMC9500586__F3 Personalized nutrition: A review of genotype-based nutritional supplementation ALDH1A3 HEL-S-53e DHRS3 ALDH1A2 PMC11892138__F7 Eugenol accelerates intestinal stem cell regeneration to protect the intestinal barrier integrity through inhibiting JAK2/STAT3 signaling pathway in Salmonella enteritidis-challenged broiler chicks GPR49 STAT3 PMC6761967__F5 Whole driver PC3-represented PCa signaling pathway SMAD2 F2RL3 RELB SNRPN HSPD1 TFDP2 LPA MTOR SHC3 TUBB2A SIAH1 BASH SNRPA1 PARVB DKFZp434N041 GRINA PTCH2 CSK TNF CBL HEL-S-125m CACNA1I LEF1 ADRA1B PMAIP1 ORC1L PMC6829248__F2 Summary of natural product regulation in proteostasis machinery MDM2 RB1 MTOR PMC3443258__F6A An inventory of peroxisomal proteins and pathways in Drosophila melanogaster GNPAT HEL-S-5 PMC8834581__F3 Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle GC SRC HCTP4 PMC6305227__F1 Propionibacterium acnes: loss of diversity, selection of phylotypes, and its different target activities in acne CRH CD44 PMC6639256__F7 READ pathways (p53 signaling pathway, intestinal immune network for IgA production, and colorectal cancer pathway) enriched in DEmRNAs during READ BAD ATM APC PMC3329340__F3 Simplified TOR signaling network with known Arabidopsis homologs in Italic writing TSC2 RICTOR TSC1 MLST8 PMC5469033__F1 Adipose Tissue NAD+ Biology in Obesity and Insulin Resistance: From Mechanism to Therapy NAPRT SIRT2 NAMPT SIRT7 SIRT4 SIRT5 SIRT6 SIRT1 NRK SIRT3 PMC9928999__F2 Regulatory effects of oral microbe on intestinal microbiota and the illness TJP1 TLR4 CCL20 S100A9 PMC8419056__F3 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment NLRP3 HMGB1 TLR4 EGFR TNF GSDMB PMC8419056__F2 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment NLRP3 HMGB1 GSDMC STAT3 BAX PMC5079533__F4 Ingenuity pathway analysis of endocrine networks depicted in through AIP CASR CALCA SLC34A1 REN APLN INS CYP24A1 RXRG ADRB2 BGLAP FGFR2 INSR KL LEP FGFR1 NR1i1 TRH opn LEPR GNAS ACE2 UCP3 PMC7577320__F1 Malic Enzyme 1 (ME1) in the Biology of Cancer: It’s not Just Intermediary Metabolism ME2 ACLY ME3 HEL-S-133P FASN PMC3472558__F1 EGFR signaling pathway (reprinted with permission from BioCarta Pathways EGF FOS GRB2 RAF1 JAK1 STAT3 PMC10644365__F2 Signaling pathways associated with ERA TSC2 TSC1 APC GRB2 PTEN MTOR TF RHEB PMC4688235__F2 Recent advances on viral manipulation of NFKB signaling pathway CGAS TLR7 TLR9 CCL5 MYD88 TLR3 MAVS IFI16 PMC6293255__F5 Top two networks (A and B) identified by Ingenuity Pathway Analysis as overrepresented within the list of 245 genes (P < 0.005) dysregulated in human IAPP transgenic (HIP) vs GABBR1 PLAUR FOS TP63 ATF3 CCL2 PPARG NPAS2 SERPINB2 RAMP3 SERPINE2 PMC6277408__F4 Analysis of p53-pathway in relation to miRNA expression and potential targets CASP3 CASP9 BAX PMC8631789__F5 Overt Acute Hepatitis B Deteriorates in Females: Destructive Immunity With an Exaggerated Interleukin-17 Pathway IL4 IFNG PMC2494844__F2 Genomic dissection of the cytokine-controlled STAT5 signaling network in liver SOCS2 SOCS3 GHR PMC3089989__F2 Gene expression pattern of the P38 MAPK signaling pathway MAPKAPK2 MAX TIFA MAPKAPK3 TRAF2 PMC4688235__F1 Recent advances on viral manipulation of NFKB signaling pathway CGAS TLR9 DDX41 TRAF6 CCL5 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 FADD TIRAP MAVS IFI16 TAB3 PMC9102649__F4 Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non‐small cell lung cancer cells via p53‐p21 signaling pathway CDCA5 CDK2 CDK4 CDK6 PMC9460126__F7 Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation ULK1 VASN MTOR PMC11795593__F7 Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken SPHK1 SGMS2 CERS6 PMC7136521__F1 Angiogenic and vasculogenic mimicry promotion by CSCs is mainly triggered by VEGF among several types of cancer CCR3 CD34 FZD2 DKK1 STAT3 PMC11989355__F4 KEGG pathway diagram TH HEL-S-11 POR PMC4088997__F5 Rapamycin and paclitaxel nanoparticles synergistically target the PI3K/Akt/mTOR pathway by suppressing feedback loop Akt phosphorylation BAD PTEN IRS1 PMC5687841__F6 Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis EGF NGF MGLL RELB MYD88 TNF LTA SDC4 RELA LCK ZAP70 SPHK1 VCP REL TGFA SERPINB2 LTBR TIRAP TAB3 PMC5474292__F3 Nodes linking the enriched KEGG pathway by hub genes MYH9 PLK1 BTRC FOS EGFR MYC LMNA MAP2K6 IRS1 PRL TK1 INSR GADD45B EDNRB NFKB2 CDK2 MDM2 PTK2B NOS2 IL4 PPARG JUN RPS6KA2 PMC4614816__F1 Cells express exosomes comprising lipids however lipids impact on cancer cells according to cell phenotype CXCR4 NOTCH1 PTEN PMC9354757__F1 Profile of Glasdegib for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML): Evidence to Date SUFU GLI3 SMO PMC9406051__F9 Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma RBPJ CAMK2D HID1 UBE2D3 NFKB1 IRF4 PMC4107453__F8 Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation TSC2 SIK2 CDK5 PJA2 PMC3634440__F1 Gene regulatory networks of plant transcription factors (TFs) in plant abiotic stress responses and abscisic acid-dependent gene expression MYB SNRK ERF PMC9352922__F3 PKCA and PKCD: Friends and Rivals CDK2 SRC CDK4 CDC2 CDC25B MTOR PMC6425079__F1 Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity NEIL2 IL1A NEIL3 OGG1 NEIL1 PMC10995224__F2 Signaling pathway that was affected by ridaforolimus TSC2 PHLPP2 PTEN MTOR DEPTOR PHLPP1 PMC9304707__F2 What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells HDAC3 EGFR EIF4E PMC12037492__F1 Mechanisms via which TYMP promotes platelet activation and osteoclast differentiation FYN NFATC1 LYN TRAF6 SYK TYMP PMC4770095__F2 Regulation of Th2 Cell Immunity by Dendritic Cells IRF8 CCR7 KLF4 CD40 IRF4 PMC2731164__F7 Embryonic Stem Cell Differentiation E2F4 PLK1 IRAK2 MYD88 RB1 SMC1A DFFA APAF1 MDM2 CASP8 CASP12 CDKN1B CDC25B MCM3 MCM5 CDC20 MCM6 MCM2 CDKN1A CDKN2B CDC6 CDK2 TNFRSF1A MAP3K14 IRAK3 CASP6 CHUK BAD TRADD SFN CDKN2D IL1R1 CCND3 DBF4 PKMYT1 CDK7 CCND2 FZR1 CHEK2 RIPK1 DFFB ATM BIRC3 PRKDC RBL1 BAX CHEK1 HDAC1 NFKBIA CREBBP BUB1B RELA TNFRSF10B SMC1B ESPL1 PMC12037492__F3 Mechanism via which TYMP modifies epigenetic and resists apoptosis TYMP catalyzes the conversion of thymidine to thymine and 2DDR, which binds to integrin AVB3/A5B1 on progenitor cells, thereby activating the PI3K pathway RUNX2 IRF8 MDM2 TYMP PMC5321802__F2 Regulation of hepcidin expression in hepatocytes in response to iron status and requirements (left) or inflammation (right) BMP6 JAK1 STAT3 PMC9326259__F9 Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking and Cytokines Validation CPB2 HEL-S-62p CS TFPI F8 FH VWF F11 CR2 CD19 PMC8113755__F1 WNT plasma membrane signaling in PDAC TSC1 RNF43 APC GSK3B MYC LRP5 LRP6 PORCN GPR49 MTOR PMC6493202__F6 Neuroprotection by Sildenafil NGF ARHA PTEN BDNF PMC7408575__F2 JAK-STAT canonical signaling pathway EPO TPO IL24 PMC5703970__F3 C-T-P network ADCY1 PTGS2 MMP9 TNF PTGS1 AGTR2 CALM1 HEL-S-102 NTSR1 MMP2 F2 APP GRIN2B NOS2 HTR2A PBR PMC5703970__F4 Neuroinflammation pathway and therapeutic modules GNRHR BAD ADCY1 PTGS2 PTGS1 HEL-S-102 PLN CASP3 MMP2 APP SRC NOS2 HTR2A CDC42 PMC7795265__F6A Proteomic Profiling of the First Human Dental Pulp Mesenchymal Stem/Stromal Cells from Carbonic Anhydrase II Deficiency Osteopetrosis Patients GLB1 AIP YBX1 KDM3A GNAI3 PCOLCE FERMT2 S100A4 PLOD2 PMC9646750__F1 Advances in multi-omics study of biomarkers of glycolipid metabolism disorder PNPLA3 DPP4 TCF7L2 ABCC8 PMC3003706__F7 Distinct B1 and B3 integrin pathways converge to regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells CD47 SRC RAC1 TRIO PMC478571__F3 Chart of cell cycle genes POLD4 CCNA2 ORC6 CCNH RB1 ORC3 CDK7 CDC45 ORC2 CCNE1 MCM3 MCM5 MCM6 MCM2 CDC6 CDK2 CCND1 CDK4 PCNA SKP2 CCNE2 PMC4232069__F2 A FOXO3-driven pathway abrogates inflammatory responses in a transforming growth factor (TGF)B1-dependent manner FOXO3A TGFB1 IL1B PMC8082541__F1 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue PRDM16 UCP1 ATF2 NR1C1 SIRT1 TRPV1 TRPM8 PMC8616505__F2 Interplay between the Unfolded Protein Response, Inflammation and Infection in Cystic Fibrosis ELF2 NFIB ATF4 TRAF2 XBP1 PMC7798015__F4 Direct and indirect intracellular effects of CCN proteins in chronic myeloid leukemia (CML) CYR61 NFKB1 NOTCH1 CCN3 CCN4 CTGF BAX PMC8299052__F4 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway MCU SIRT3 PMC7798015__F2 Complex regulation of CCN2 expression, and the diverse actions of the CCN2 protein, as reported in literature GDF5 EGFR DCSTAMP VWF CCN3 RHO IGF2R CTGF PMC8299052__F1 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway EFHA1 MICU1 MCUB MCU C6orf79 PMC9695228__F11 Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core BOC CDON SUFU GSK3B SMO GAS1 KIF27 ADRBK1 PMC11520086__F3 Metabolic pathway and enzyme gene expression difference of C1 compounds in the transcriptome group, Formaldehyde vs GCK GAR1 CIT HYI PMC7010578__F4 Major pathways and genes related to major depressive disorder (MDD) MALL NTRK1 DRD1 DRD2 GRIK2 CRK CASP3 FRS2 ERBB2 GRB2 BDNF TGFA NTRK2 PMC6186337__F1 In this figure, we consider potential mechanisms regulated by physical activity and caloric restriction in inhibiting the mTOR pathway IGF1R IGF1 MTOR PMC3657575__F10 The signaling pathways involved in calpain-mediated regulation of dendritic protein synthesis induced by BDNF PTEN MTOR BDNF PMC5635727__F2 Lut alleviates I/R injury by inhibiting apoptosis by up-regulating AKT, increasing BCL-2 protein and decreasing BAX protein PLN KEAP1 BAX HEL-S-69p PMC6323179__F6 Proteome changes in (A) G-protein signaling pathway, (B) calcium signaling pathway and (C) ginsenoside synthesis pathway and (D) ribosomes biogenesis, ubiquitin-mediated proteolysis and RNA transport pathway ELF2 EIF5B PC ELF3 RPN2 RAN IPP NUP155 PMC8953452__F1 HOG pathway and the regulation of osmoadaptive responses in yeast MRC1 CIB2 C6 CIB4 TF CIB3 PMC5390025__F2 Host-Helminth interaction: There are two sides of immune response against a parasite invasion, one leads to worm survival in host and the other to worm killing IL33 IL25 ARG1 PMC7830946__F7 Nuclear factor erythroid 2 (NEF2)-related factor 2 (Nrf2) signaling pathway of oxidative stress KEAP1 PMC3110895__F4 Modeled miRNA mediated pathways in the pathogenesis of lung fibrosis APC TNF BAX PMC2634254__F2 Embryonic liver development AFP HNF4A HGF ALB FGF2 PROX1 BMP4 PMC4013402__F1 Glucose and glutamine metabolism in cancer cells SLC5A1 SLC7A1 GLS PMC2634254__F4 Upstream regulators and downstream targets of Beta-catenin during embryonic liver development FGF10 CCND1 SFRP5 BMP4 PMC4889573__F2 cAMP intracellular signaling pathways in target cells of Treg suppression NFATC1 CD83 CD80 PMC4138319__F3 miRNA- and TF-mediated sub-network specific to the TGFB signaling pathway ANAPC7 GCLC TGFBR2 FZD4 MAGI3 STK39 SLC38A1 CDK6 SYNPO2 PDZD2 SPOCK2 MMP14 QK3 ITGB8 CDK4 IL6ST TNS3 ATP2A2 HEL-S-93 IRF-1 FRMD6 PMC7915382__F1 Aldosterone signaling pathway most significantly affected by oregano with 19 genes ICMT CRAT NEDD4 PMC7188969__F2 CD36 in Type 2 Diabetes Mellitus: Beta-Cell Dysfunction and Beyond NLRP3 SRC TXNIP CD36 PMC8042171__F2 Genetic glycoengineering in mammalian cells TMTC1 GCNT3 UGCGL2 ST3GAL3 TMTC4 LARGE ST8SIA5 ST8SIA6 B4GALNT2 B3GNT6 B3GALNT2 B4GALT5 ST8SIA2 EXT1 PIGV B3GNT3 B3GALT1 XXYLT1 ST3GAL6 SIAT4C COLGALT1 GXYLT1 GALNT9 GXYLT2 GALNT8 CHPF2 ALG2 GalNAc-T18 B3GNT9 ALG3 B3GNT8 B3GNT7 B3GNT4 B3GNT2 PIGM ST6GALNAC4 B4GALT4 EXTL1 CHSY1 GCNT4 UGGT1 GCNT7 GALNT5 B3GAT3 FKRP GALNT4 C1GALT1 DPY19L1 DPY19L2 DPY19L3 GALNT6 DPY19L4 FUT1 FUT4 FUT6 FUT5 GCNT1 POFUT2 FUT7 POFUT1 FUT8 UGCG ST6GALNAC1 LFNG MFNG GALNT7 A4GALT CSGALNACT1 ST8SIA4 XYLT1 ABO OGT CHSY3 ST3GAL1 GALNT3 B3GAT1 TPO PIGA ALG13 MGAT3 MGAT5B MGAT1 MGAT4D STT3A GALNT1 TH UGT8 ALG8 B3GNT5 B4GALNT1 ALG10 CHPF GAL B4GALT1 EXTL2 ST8SIA1 B3GALT4 ST6GALNAC6 FUT3 ALG1 GALNT12 POGLUT2 GALNT16 STT3B PLOD3 GALNT10 RXYLT1 LARGE2 POGLUT3 CSGALNACT2 ST6GALNAC2 MGAT2 B3GLCT GCNT2 TMTC2 ST3GAL5 PMC7142254__F3 Targeting USP7-MDM2/MDMX-p53 network for cancer therapy GNE MDM2 PMC4259860__F7 Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency HEL70 ENO1 DLD SNX6 HEL-S-107 MTHFD1 HEL-S-87p HEL-S-162eP HEL-S-64p HEL-S-304 APRT EIF3S3 HEL113 HEL114 PMC2888385__F6 Nodal-Smad2 signaling regulation of the BMP pluripotency pathway in mouse ES cells NODAL FGF8 ASCL2 GATA2 PMC3479343__F7 Placental PPARG Regulates Spatiotemporally Diverse Genes And A Unique Metabolic Network DGAT1 DCAKD TG HEL-S-281 PMC5831804__F1 Major players implicated in the phenotypes associated with the deletion of GUP1 in S FAR1 ORM2 ROM1 ORM1 CDC42 SIM2 PMC8891816__F2 miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review CDK2 CDK4 IL6 PTEN CDC2 MTOR CDK6 STAT3 PMC2538516__F1 Biosynthetic relationships between amino acids, as defined by their biosyntheses and their relationships with the glycolytic pathway and the citric acid cycle UCN DAP GGN CGN PMC9485267__F1 Targeting p85B nuclear translocation for the tumors with PIK3CA helical domain mutations DLG2 EZH2 EZH1 IRS1 PMC8153134__F2 Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders CYP27A1 FGF23 NR1i1 CYP2R1 CYP24A1 PTH CYP27B1 PMC5827181__F2 Toward novel ways of MALT1 activation? BCL10 BCR TRAF5 TRAF3 TRAF6 TRAF2 TRAF4 PMC5827181__F1 The waves of MALT1 activation CARD11 BCL10 TRAF6 PMC9001993__F5 2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NFKB pathways in Raji cells EGR1 BAD BRAF TRADD FOXO3A FOS LAMTOR3 CDKN1B PTEN RB1 HRAS ITGB1 FOXO1 NFKB2 NFKB1 ARAF PMC6311529__F7 Proposed model of LUBAC-mediated ubiquitination on cFLIP in the TNFA receptor signaling pathway RIPK1 TRADD TRAF5 RNF31 SHARPIN TRAF2 FADD PMC4027966__F3 Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes GNG2 KCNMA1 TPMT ATP6AP2 FRMD4B UTP18 PMC5960485__F8 Network showing the most important gene interactions for the “regulation of canonical WNT signaling” (GO term GO:0060828) pathway AGO2 LEF1 WNT1 AXIN1 LRP5 hCG_2014051 AXIN2 DVL1 PMC7731198__F4 Novel mechanism of lysostaphin resistance in ST72 isolate and its associated metabolic pathway DHFR DHPS PMC6198057__F1 Scheme depicting the main upstream and downstream regulators of mTORC1 signaling pathway TSC2 TSC1 BCL2 GIP SIRT1 RHEB PMC7991912__F2 Pathway overrepresentation and gene ontology analysis of cisplatin-induced significantly deregulated proteins RPS14 RPL36 RPL35 RPL6 RPL13 AARS1 RPSA PHGDH SH3BGRL3 RPL23A RPL17 RPL29 RPL7 ELF4 RPS20 FASN PMC7491384__F3 Dietary Regulation of Immunity NLRP3 EIF2A PMC10141597__F1 Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids BCR MBP CD40 PMC7965690__F4 How MARylation is predicted to be involved in the regulation of colorectal cancer AHR APC GSK3B MACROD2 PMC2874225__F1 The DSBR and SDSA meiotic recombination models SPO11 DMC1 RAD51 PMC5715672__F3 Pathway of catecholamine biosynthesis TH PNMT DBH PMC7436979__F6 Components-Targets-pathway network EGF PTGS2 MMP9 EGFR MAPK3 VEGFA CCL5 IL6 TNF HMOX1 IFNG CASP3 EDN1 TLR4 RELA BCL2 MAPK1 NOS2 JUN IL1B PMC5500762__F3 Lysine acetylation events involved in carbon fixation (A), tricarboxylic acid cycle (B), and photosynthetic pathway (C) CS MNT FES RPIA CYB ASPA HEL107 SDHA SDHB PMC3465263__F10 Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice PTEN PCMT1 PMC3479191__F5 Multilevel factors cooperatively perturb pathways GDF5 ID4 PPP2R2C MYC E2F5 RB1 HRAS CDKN2A SMURF1 RASSF1 EP300 CDKN1A BMPR1A E2F2 SMURF2 CCND1 MAPK1 COMP SMAD1 ARAF INHBB INHBA DKFZp781O1323 INHBE PMC11281550__F6 Changes in metabolites in PI3K/AKT/FOXO signaling pathway after TeA, PAT alone, and combined exposure SET ATG12 EGFR INS SMAD4 PTEN INSR NLK ATM CDK2 MDM2 KLF2 BNIP3 SIRT1 SKP2 STAT3 PMC5996928__F5 Molecular signaling pathways involved in astrocyte reaction in AD HEL-S-62p IL18 TF STAT3 PMC3466807__F1 BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer TSC2 TSC1 PTEN MTOR RHEB PMC3604893__F1 A) Model of multi-agent vs MUC1 BCR ALOX5 PMC4713514__F5 Focal adhesion pathway analysis based on the KEGG database VASP BAD FYN HEL-S-28 SHE ARHA PTEN CRK PMC9630602__F2 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases NLRP3 MDM2 TRAF6 IRF3 PTEN MYD88 FOXO1 GSDMD DFNA5 PMC9630602__F4 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases TBK1 TRAF6 IRF3 PMC12185430__F2 Gut microbiota-derived metabolites in MASLD pathogenesis under dysbiosis CD14 TLR4 AHR LBP FGF19 MTOR CYP2E1 PMC12185430__F3 Botanical drugs-mediated immunomodulation through LPS/TLR4 signaling TLR4 MYD88 TNF PMC5635727__F3 In HF, SERCA2a is a vital target regulated by Lut for effective cardiomyocyte contraction and relaxation PLN SUMO1 PMC12185430__F1 Mechanistic framework of the “multiple-hit” hypothesis in MASLD progression The pathogenesis of MASLD involves sequential pathological hits driving progression from hepatic steatosis to end-stage liver injury TLR4 IL6 TNF TG PMC12205216__F2 Natural products downregulating TGF‐B pathway in treatment of leukemia SMAD2 SMAD4 CCND1 CDK4 CDK9 PMC7397827__F1 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) RIPK1 TNF TLR3 MLKL PMC6945981__F5 Effects of perlecan deficiency on transcriptome changes in (A) the 1-day study groups and (B) the 7-day study groups VWF CHAD PMC6030166__F6 Combined network analysis of metabolites and lipids FOLH1 MYC BCL2L11 UBB HMOX1 ATAD2 UBC SLC25A12 GOT2 CIC PAICS APOE SDHA PYCR2 GCLM CES2 GCLC PTGS2 PSMA4 NAGS GAD1 TK1 GFPT1 HLA-B AARS2 HEL-S-69p HLA-C TTL IMPA2 HEL-S-80p MAT1A FAHD1 ABAT AIMP2 FARSB ASNS PIK3CA ACLY SGMS2 ACD PMC4770165__F1 Aryl hydrocarbon receptor signaling pathway is depicted with 3,3′-diindolylmethane as a model agonist AHRR AHR CYP1B1 CYP1A1 CYP1A2 PMC6030166__F8 Central carbon metabolism in cancer TIGAR MYC GCK PTEN SLC16A3 HEL-S-32 SIRT3 ERBB2 SIRT6 PFKFB2 OGDH ACLY HEL-S-133P ELL GLS PMC7397827__F5 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) TNF TLR3 ZBP1 MLKL PMC12205216__F3 Natural products upregulating TGF‐B pathway in treatment of leukemia SMAD2 SMAD4 PMC12205216__F4 Natural products targeting TGF‐B pathway in treatment of colorectal cancer SMAD2 SMAD4 PMC8269285__F10 Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma F2 VEGFA ATF3 REST MAL PMC5384023__F7 tmTNF-Alpha-induced STAT1-dependent apoptotic signaling via TNFR1 STAT1 TRADD TRAF2 FADD PMC11662063__F6 Proposed model suggests that SS18-SSX drives the acitivation ofTYK2/STAT3/Bcl2 axisthereby mediating apoptosis evasion in SS cells BCL2 TYK2 STAT3 PMC5414786__F7 Components of insulin signaling pathway and the up-regulated genes with H3K27ac- or H3K4me3-increased regions by decidualization GRB2 SHE MTOR FOXO1 INSR CBL PMC3261278__F1 Synaptic translation and signaling pathways modulated by FMRP (a) and dysregulation of these pathways in the absence or significant reduction of FMRP (b) DLG2 MMP9 APP ARC EIF4E PMC3261278__F2 Targeted treatments for fragile X syndrome ARC PTEN MTOR CYFIP1 PMC7034838__F3 Iron metabolic pathways in the processes of sponge plasticity FECH UROD UROS CPOX NGB PMC11728517__F4 Extrinsic and intrinsic apoptosis pathway TRADD TRAF2 FADD BAX PMC8229991__F2 Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from Fibrodysplasia Ossificans Progressiva Patients ACVR1 SMAD2 ACVR1C SMAD4 SMAD9 FSTL3 FST BMPR2 ACVR2B ACVR2A SMAD1 INHBB INHBA DKFZp781O1323 PMC11954783__F2 Review of recent molecular pathology of bladder urothelial carcinoma ZNRF3 RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC7509150__F5 KEGG analysis for signaling pathways TH CXCL1 TRADD TRAF3 TRAF6 LPA NOD2 MMP3 BCR ATM BASH SI JUN SELE CD14 NPB FOS LIF LTB TNF LTA LBP LYN CD40 TRAF2 FADD LAT TIRAP PMC6414514__F4 Dynamic mechanism of ADP-ribosylation reversal NUDT5 MACROD1 NUDT16 PARG MTOR PMC7556678__F1 Thromboinflammatory pathways in sickle cell disease TLR4 VWF TF PMC9559307__F1 Biomarkers in the Management of Colorectal Liver Metastases EGF BAD IGF1R IGF1 APC GSK3B PTEN BAX PMC3156642__F1 Crosstalk between the canonical and non-canonical transforming growth factor-beta1 (TGFB1) and myostatin pathways SMAD2 SMAD4 PMC12139502__F2 Proteome features of the four major heart cell-types ACTA2 TNNC1 MYH7 RYR2 MYH1 DAG1 MCAM NOS2 ARG1 XB PECAM1 ERG CCR4 OTC ARHA GATA2 MYH6 ITGB4 HSPG2 GJA1 VTN CTNND1 MYL12B MYH13 ATP2A2 CLDN5 ASS1 JAM2 ASL CTNNA2 PMC6102278__F8 Fas-mediated EGF-induced EGFR signaling A proposed model of the robust EGF-induced EGFR signaling pathway mediated by the pro-survival, phosphorylated Fas that can lead to aggressive behavior of cancer cells is presented here EGF EGFR CCND1 SRC YES1 STAT3 PMC1876696__F1 Pathways for the synthesis of the major phospholipids in S PC TG IPP PSD PEMT PMC10928192__F1 TNF/TNFR1 signalling through complex I RIPK1 TRADD TNF TRAF2 PMC10928192__F2 TNF/TNFR1 signalling through complex II RIPK1 TRADD RIPK3 TNF TRAF2 FADD MLKL PMC10928192__F3 Interplay between TNF/TNFR1 complex I and complex II signalling pathways RIPK1 TRADD CYLD RIPK3 TNF TRAF2 FADD MLKL TAB3 PMC5058780__F2 FAK and paxillin, two potential targets in pancreatic cancer GRB2 SRC RHO PMC6902872__F1 Pathway to chronic rapamycin therapy in prostate cancerModel: Chronic mTORC1 inhibition delays of PCa progression from active surveillance EEF2 EIF4E MTOR PMC11744640__F6 Molecular mechanisms of SARS‐CoV‐2‐induced pulmonary fibrosis ACE2 TMPRSS2 IFNG PMC11744640__F8 Canonical and noncanonical TGF‐B signaling pathways SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA MTOR TRAF4 PMC11744640__F9 Important signaling pathways involved in fibrosis CGAS HEL-S-28 ATF4 TGFBR1 TGFBR2 SMO IL11RA XBP1 NR1C1 PMC308804__F4 Visualizing protein interaction networks in HPRD DRD3 KDR LCK GRB2 MAPK14 SRC SYK OPRK1 SOS1 CRK CEBPB CRKL PMC5173100__F8 Novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway CCNA2 CDK2 CDK4 CDK6 PMC7828713__F2 Microglial regulation of neuronal networks and CNS homeostasis CX3CR1 BDNF PMC3896667__F5 Significantly altered pathway in primary tumor PDGFRA MYC LAMB2 DOCK1 RB1 CRK CBL MMP7 EP300 AXIN1 MDM2 ATR PRKDC PMC4013180__F3 Multiple pathways can stimulate Beta-cell replication in obesity, and there is overlap of many of the downstream activators PDX1 HGF CAMK4 EGFR GSK3B PMC4444223__F1 Model diagram of tumor necrosis factor-alpha (TNFA) signaling TNF FADD PMC9097379__F7 ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells HMGB1 IRAK1 ARHA SYK MYD88 IL1B PMC8362831__F1 Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611 SIK2 EIF3A IL8RB PTEN MTOR DEPTOR PDGFD TIMP1 PTCH1 CXCR4 SMG1 SRC RRAGA PMC7828713__F1 Effectors of microglia function associated with neurodegeneration and how microglia damage or kills neurons HTT C9orf72 PMC6315857__F1 Transforming growth factorB 1 (TGFB1) mediates a signaling pathway in tissue fibrosis ATM SMAD2 TGFBR1 SMAD4 TRAF6 ARHA MTOR ATR PMC5696728__F2 Oncolytic virus mediated enhanced anti-tumoral immunity, including enhanced CAR T-cell recruitment and effector function BATF3 CGAS CXCL10 CXCL9 CD40 CCL4 ICOS IFNG PMC5662566__F3 Integrin-linked kinase (ILK) signaling pathway is altered following RVFV infection LEF1 NCK2 BMP2 NACA HEL113 HEL114 KRT18 PXN RSU1 PMC9483736__F8 Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress PLCG1 CXCR1 ACVRL1 TGFBR1 TGFBR2 CXCL8 IL8RB MTOR TNC ERBB2 BIRC3 PLCE1 STAT3 PMC5765116__F9 DENV2-induced autophagy is ER stress-UPR dependent, involving PERK-eIF2Alpha-ATF4 and IRE1Alpha-JNK-BECN1 pathways ATG12 ATF4 EIF2A PMC3774329__F6 The interactions between Rho/Rho-kinase signaling and bone morphogenetic protein (BMP)/transforming growth factor (TGF)B signaling GIP RHO PPIC PMC5025790__F9 Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency NODAL CRIPTO SMAD2 SMAD4 PECAM1 SMAD1 DKFZp781O1323 PMC7890422__F1 Caveolin-1, a master regulator of cellular senescence HMGB1 IGF1 EGFR MDM2 RHO SP1 SIRT1 PMC9270398__F9 Working model of TRIM24 in regulation of P-bodies in response to insulin EDC4 AGO2 TRIM24 IRS1 PMC4297187__F2 Schematic summary of the results obtained from the microarray analysis CTBP2 SFRP4 DAAM2 DKK3 FOSL1 LRP5 LRP6 DKK1 FZD1 SOX17 WIF1 TLE4 FZD7 DVL2 SFRP1 AXIN2 DIXDC1 VANGL1 TAX1BP3 PRICKLE2 PMC9174896__F2 Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years DUSP5 APC BMP4 ACTR2 PMC2757940__F2 Major components of FGF and HH signaling pathways SUFU FRS2 GRB2 SMO PMC5797063__F1 MicroRNA expression and activity in T-cell acute lymphoblastic leukemia NOTCH1 NRARP FBXW7 PMC7448411__F1 Wnt/Beta-catenin signaling by miRNAs APC GSK3B LRP5 LRP6 SFRP1 FRAT1 CDH2 HEL-S-93 STAT3 PMC7448411__F2 Use of miRNAs to combat EMT ASCL2 PMC3541304__F1 Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis TSC2 TSC1 CDKN1A HIF1A MTOR DEPTOR DDIT4 PMC3106338__F10 INTERFERON-ALPHA MEDIATES THE DEVELOPMENT OF AUTOIMMUNITY BOTH BY DIRECT TISSUE TOXICITY AND THROUGH IMMUNE-CELL RECRUITMENT MECHANISMS OAS1 TSHR CXCL10 APC TRIM21 TG PMC6851267__F8 Ghrelin attenuates neuroinflammation and demyelination in EAE involving the NLRP3 inflammasome signaling pathway and pyroptosis NLRP3 IL1B GSDMD PMC10952045__F4 Various molecular mechanism of the osteogenic and osteoclastogenic function through cellular uptake of GNPs and functionalized GNPs RUNX2 EBP BMP2 NFATC1 NPS OSCAR RAC1 OSM PMC9636824__F9 Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins CDK2 CCND1 CDK4 RB1 MTOR CDK6 PMC7484401__F4 ANM analysis on long-term PIMi treated cells finds changes in protein complex enriched for signaling and growth pathways PIK3CD MYB GSK3B MYC CDK6 PCK2 IFNGR1 SOS2 VEGFA CTSH IFNAR1 DDIT4 YWHAQ PRKCB IGF1 CDKN1A VCAM1 TRAF1 TNFRSF10A TNFAIP3 ACTG1 IFNA17 RRAGD IGF1R F2R HSP90AB1 RELB BCL2L11 EIF4EBP1 MTOR CCND2 GADD45B ATM BIRC3 THBS1 PTPN6 JUN IL2RB FGF7 BAX ITGA1 HEL-S-125m CASP3 NFKB1 TNFSF10 STAT4 PIDD1 LYN CD40 FLT3 CYCS PMC2572865__F1 Hematopoietic niche and bone meet PTH1R BMPR1A LRP5 PTH DKK1 PMC5726441__F4 PI3K pathway in human disease TSC2 TSC1 RHEB PMC5726441__F1 PI3K pathway in human disease TSC2 ITK CSH2 BTK PI3 TSC1 TEC RHO PTEN INPP4B RHEB PMC5726441__F6 PI3K pathway in human disease PIM1 BAD MYC SRC PTEN IRS1 SGK1 PMC3164321__F1 KEAP1 Cullin-3 E3-ubiquitin ligase complex and its roles in maintaining cellular levels of NRF2 and IKBKB IKBKB KEAP1 RBX1 PMC8235118__F8 Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-Bromopyruvate MAX HEL-S-44 HEL-S-162eP PMC6622839__F9 Model of VAMP3- and VAMP7-dependent surface transport VAMP3 VAMP7 SNAP23 PMC9255244__F3 Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response TLR4 CFD BIRC3 MYD88 NFATC3 PMC7816800__F4 Functional interactions between genes under positive selection in the insulin signaling pathway (ingenuity pathway analysis, IPA) LIPE BAD VAMP2 SOCS3 GRB2 PTEN ACLY GRB10 CRK CBL PMC7816800__F5 Functional interactions between genes under positive selection in the SIRT signaling pathway (ingenuity pathway analysis, IPA) RARA RELA WRN PMC7816800__F6 Functional interactions between genes under positive selection in the NF-ĸB signaling pathway (ingenuity pathway analysis, IPA) EGF LTA NGF TRADD RELB HDAC2 CD40 TIRAP PMC7816800__F7 Functional interactions between genes under positive selection in the mTOR signaling pathway (ingenuity pathway analysis, IPA) TSC2 PC ELF3 RHO EIF4E MTOR EIF4B IRS1 RHEB INSR PMC7369834__F1 Genomic and non-genomic effects of glucocorticoid receptor (GR) binding to the different players of the inflammatory and metabolic pathways involved in the Duchenne muscular dystrophy (DMD) myocyte MTOR IRS1 DMD PMC8020906__F2 mTOR is activated by growth factors via PI3K-Akt and RAS/MAPK pathways PTEN RHEB PMC11853774__F1 Crosstalk between the Hedgehog (Hh) and PI3K pathways in hematological malignancies FOXC1 SUFU GSK3B SMO FLT3 MTOR PMC5290741__F5 Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine TSC2 TSC1 PTEN MYD88 TLR1 MTOR RHEB AKT3 PMC8827382__F2 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets ULK1 ATG12 ATG3 AMBRA1 ULK2 UVRAG ATG10 ATG14 DKFZp686F0183 PMC8827382__F1 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets MDM2 BCL2 TNF MTOR FADD BAX PMC4472234__F4 Elementary Flux Mode Analysis Revealed Cyclization Pathway as a Powerful Way for NADPH Regeneration of Central Carbon Metabolism KIT PTS CS PGC RPE PMC7335672__F9 miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells PTGIR PTGIS LTA COX1 KPG_011 LTB LTC4S PTGDR PMC8020906__F5 Interplay between HBP, mTOR, and AMPK signaling pathways TSC2 GYS2 ULK1 TSC1 OGT GYS1 PTEN RHEB PMC8020906__F3 mTOR in cancer stem cells (CSCs) SOX2 PMC8020906__F4 AMPK pathway activation and energy homeostasis ULK1 TXNIP GYS1 HMGCR CAMKK2 PMC8469128__F1 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling ENG FURIN SP1 PMC7929927__F8 BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection TMED9 C20orf185 PMC8469128__F2 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling EGR2 TRAF6 SPRY1 PTEN MTOR COL1A1 PMC5404743__F1 New Milestones Ahead in Complement-Targeted Therapy HEL-S-62p CS FH CR2 COMP PMC7401802__F1 Biosynthesis of CL and PE HMFN0839 PGS1 PC MOG PRELID1 PLSCR3 AGPAT4 AGK PGP PTPMT1 LPA PISD PMC4933442__F8 TNF-Alpha-induced expression of the inflammation-associated genes mediated by PLCE CXCL1 CXCL8 CCL2 LPA PMC1905845__F1 Schematic representation showing the plausible signaling events from uPAR integrin complex BAD PLG PTEN MTOR FADD PMC2662295__F5 TRAF6- and MEKK1-mediated signal for IFNB production in the RLH/IPS-1 signaling pathway TRAF3 TRAF6 IRF3 FADD PMC8160027__F2 Vital role for nitric oxide in intraocular pressure homeostasis NOSTRIN PLCG1 NOSIP PMC8160027__F3 Vital role for nitric oxide in intraocular pressure homeostasis PIEZO1 SRC PECAM1 PMC2905744__F3 Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors BAD PTEN MTOR PMC3826168__F2 Molecular mechanism and function of CD40/CD40L engagement in the immune system TRAF3 CD40 TRAF2 PMC3013016__F8 The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling TSC2 TSC1 EIF4E RHEB PMC8534692__F7 Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice HK3 NPC1 SC5D ACSS3 MOGAT2 ACOT12 HEL-S-5 ACSS1 FDFT1 SOAT1 PGAM1 MSMO1 FABP1 PMC6411465__F9 A schematic diagram illustrating the proposed mechanism of AR‐CD44‐SOX2 signaling SOX2 CD44 PMC7759768__F3 Major sources of oxidative stress in Parkinson’s disease and the corresponding antioxidant defense mechanism in dopaminergic neurons TH CASP3 DKFZp666G145 BAD HEL-S-11 GFAP CASP9 BAX PMC9139943__F3 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance FEN1 SSB ATR MRE11A PMC8842882__F1 Signaling networks orchestrate metabolism for coordination of T cell fate MYC IRF4 BATF PMC11049012__F1 BCG-driven activation of the bladder cancer TME involves the NFKB/TNFA signaling pathway and IRFs/IFN pathway COX2 CXCL10 CXCL9 CXCL8 CCL5 CXCL12 TNF CCL22 CXCL11 PMC9139943__F4 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance E2F4 RAD51 BRCA1 PMC9139943__F6 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance PALB2 SLFN11 SSB PARG PMC7956519__F2 Main non-canonical signaling pathways activated by JAK2V617F in Ph-negative MPNs EPOR BCAM ATF2 TRAF6 MYD88 TIRAP PMC7956519__F3 Major non-canonical mechanisms derived from CALRMut FLI1 RPL11 HEL-S-89n TAP2 HEL-S-269 APC HEL-S-72p OXR1 MSI2 TAPBP PMC4178743__F7 Interference in type I IFN production by HEV proteins IRF3 TRIM25 MAVS PMC11737358__F2 Metabolic pathway of homoarginine (hArg) synthesis and associated substrates SLCO4C1 OTC ARG1 ASS1 ASL PMC99537__F5 Basic metabolic pathways in C PTS GHR FES PMC3244200__F4 Epithelial–mesenchymal transition (EMT)-related pathways EGF FOS EGFR SHH JUN PMC6099423__F1 Model about the effect of indoleamine 2,3-dioxygenase 1 (IDO1) on the utilization of the main energy sources by activated CD4+ T-cells IDO1 AHR CPT1A APC CPT1C PMC6028720__F3 Compound–target–pathway subnetwork of 12 compounds relating to AD SIRT2 ADORA2B TLR9 DAO GSK3B MAPK14 MAOA DRD1 DRD2 PTGS1 GGPS1 HSD17B10 HPGD BCHE ABCB1 CES1 MAPK10 MVK HTR7 AURKB CYP2C9 SLC18A2 CDK2 BCL2 CA12 BACE1 CHRNA7 EGFR ALOX15 NOX4 TNK2 SLC6A2 VKORC1 HCAR3 ATAD5 KIF11 SIRT3 F3 PTPN1 ELANE ABCG2 HSD17B3 TRPA1 GMNN PRSS1 POLK PTGS2 NFE2L2 PTGES PARP1 TNKS HSD17B1 CYP2A6 CHEK1 TNKS2 CYP3A4 PSIP1 ABCC1 MCL1 DHODH CHRNB2 PMC7118423__F2 The angiotensin-converting enzyme 2 (ACE2) signalling pathway involved in SARS-CoV-induced CCL2 expression CCL2 ACE2 PMC7864727__F1 Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor HEL-S-102 STEAP3 FACL4 DPP4 FES PMC3666381__F1 Metabolism in totipotent stem cells PC CAD HEL-S-133P PMC3666381__F2 Metabolism in pluripotent stem cells HEL-S-49 GLDC HEL-S-162eP PMC5852605__F1 Canonical and non-canonical Wnt pathways and their effects in pluripotent stem cells (PSCs) ATF2 APC RHO PMC11889860__F5 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies CD14 CTSK TLR9 IRF9 TRAF6 IRAK4 RAC1 MYD88 LBP CD40 TYK2 CSA2 FADD TIRAP PMC11889860__F6 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies TRADD CD5 FOS LIF CXCL10 IL6 TNF NOD2 IL15 MMP3 CASP3 EDN1 CYLD CD2 JUN FADD MLKL SELE PMC3965173__F1 Signaling pathways that can be inhibited to increase the radiation response of tumors BAD EGFR PTEN MTOR PMC8941656__F1 Evaluation of Iron Deficiency and Iron Overload BMP6 EPO HFE IL6 TFR2 PMC5287922__F2 Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases IL23R IL12RB1 PMC1237009__F1 Will the Real Cholesterol Transporter Please Stand Up ABCG8 ABCG5 NPC1L1 ABCA1 ARF1 TG ACAT2 PMC11049059__F8 CCN1-mediated signaling pathway in pregnant women with SARS-CoV-2-infection PIGF CYR61 TGFBR1 ENG PMC7483921__F7 Inhibition of Wnt/Beta-catenin signaling by TcdA WNT3A APC GSK3B CCND1 RAC1 CPD PMC8145791__F14 TRPC channel-derived calcium fluxes differentially regulate ATP and flow–induced activation of eNOS TRPC4 TRPC3 ORAI1 PMC5086093__F7 Models depicting consequences of PNH-related mutations on NEDD4L stability and PI3K/Akt/mTOR and TGFB/Smad pathways TSC2 TSC1 SMAD2 DAB1 RHEB PMC2829061__F7 Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair SIX5 RAD51 CDC2 PMC7452853__F11 Proposed mechanisms associated with 10% XCDM-induced hTM cell stiffening and Wnt pathway activation-mediated rescue of cells from stiffening ACTA2 LRP5 CD44 LRP6 ARHA AXIN2 TNLG7C CAVIN1 PMC8504146__F5 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential HEL-S-11 ENG PMC12254798__F1 Obese adipose tissue (AT) microenvironment interacts with tumor cells during cancer progression IL10 NLRP3 HEL-S-104 STAT3 PMC8504146__F2 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential EGFR CDH2 AXL PMC11356869__F1 Signaling pathways in osteogenesis and osteoclastogenesis CTSK RUNX2 BMP2 NFATC1 SMAD4 TRAF6 SMAD1 DKFZp781O1323 PMC11356869__F2 East Asian Herbal Medicine (EAHM) effect on bone to prevent osteoporosis MMP3 COX2 RUNX2 BMP2 IRAK1 TRAF6 MYD88 PMC8536789__AF1 Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease DGAT1 LAMP2 ATF4 PMC7886759__F3 Lipotoxic UPR induces hepatic cell death EIF2A BCL2 ATF3 TRAF2 PMC10141502__F1 Nutrigenomic profiling of reduced specification diets and phytogenic inclusion effects on critical toll-like receptor signaling, mitogen-activated protein kinase-apoptosis, and PI3K-Akt-mTOR gene components along the broiler gut TSC2 CHUK LTA TLR4 TRAF6 IRF3 LITAF IL6 MYD88 HRAS TLR3 PMC7886759__F4 Modes of cell death in NASH NLRP3 MLKL GSDMD PMC6102695__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating ‘hsa05200: Pathways in cancer’, as identified by pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery BAD HAL KMO PMC6500972__F8 Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents PARP1 RNF146 BRD7 PMC3210466__F1 MTOR signaling pathways TSC2 RICTOR TSC1 DISC1 PTEN EIF4E MTOR RHEB PMC4991447__F9 Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1A via the PI3K/AKT/mTOR pathway CDH2 MTOR PMC7986493__F10 Glycine, serine, and threonine metabolism pathways of L PSAT1 PSPH AGXT PHGDH PMC3370224__F9 The ARF6 signaling pathway involved in HLHCGR internalization as deduced from the present study LHCGR ARF6 PMC5357501__F4 The significance of SIRT1 in Alzheimer’s disease BACE1 RARB APP ADAM10 SIRT1 PMC5038066__F7 Proposed model for Leishmania donovani-mediated host TLR2 downstream signaling COX2 NFATC2 TLR1 PMC4484471__F8 Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2 MACC1 HGF TWIST1 GC PMC7809420__F5 Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration CDA CYBA VASP NGF EMILIN1 GEM EFNB2 RERG FGFR2 PTPRS SOWAHB GPC1 CMIP MYL12A MMP27 SMYD4 TINAG EDEM2 LRCH1 ASPG PDCL FNDC10 CERK JUN RHOB HAND2 GLA BAX MAL MGAM SET HAMP TUBB RGS2 PROCR LNX2 HPSE LRAT MMP14 CDIPT LBP ADAM10 HEL113 EHHADH PMC6305110__F1 Promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy HHLA2 HEL-S-92n CD80 LAG3 PMC8169545__F2 Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015–2020 updates LPL SYK ADAM10 ADAM17 APOE PMC5489658__F8 Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways TBK1 STAT1 STAT2 IRF3 IFNGR2 TYK2 JAK1 IFNAR1 IFNGR1 MAVS IFNLR1 PMC4399027__F2 Activation of the MAPK pathway in thyroid cancer RET BRAF NTRK1 AGK ETV6 NTRK3 TPR AKAP9 PMC6302542__F3 Leptin regulates fatty acid oxidation in muscle by activating AMPK POMC NPY AgRP MC4R PMC3068086__F5 Coordinately up-regulated cell cycle genes in CD8+ T cells from the VIR group (VIR versus BDL) illustrated in cell cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) CDK2 CDK7 PCNA PMC3068086__F6 Branches of MAPK pathway significantly enriched in CD4+ T cells from the LTNP group (BDL versus LTNP) NFKBIA MAPK9 CREBBP FOS GRB2 MAP2K3 HRAS JUN NFATC3 CDC42 PMC4012993__F6 Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation F2R DKK3 HEL-S-28 WNT7A APC GSK3B FZD1 WIF1 PAG1 RARA WNT4 SRC NR1C2 CCND1 SOX5 AXIN2 FRAT1 JUN TCF4 AKT3 APPL1 PMC7037284__F1 Guanylyl cyclase-cGMP signaling pathway NPS PGC CNP PMC6028303__F2 Revisiting antipsychotic drug actions through gene networks associated with schizophrenia EP300 PTN MED19 SREBF2 RRAS FURIN DRD2 MDK MEF2C NCAN TCF4 AKT3 PMC9130392__F1 mTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients TSC2 TSC1 RHEB PMC9406168__F6 Integrative, In Silico and Comparative Analysis of Breast Cancer Secretome Highlights Invasive-Ductal-Carcinoma-Grade Progression Biomarkers EGFR MYC FBN1 SMAD4 MTOR DAG1 PCSK9 GPC1 LGALS3BP LDLR CCND1 FZD7 ASCL2 THBS1 SP1 LAMA5 LAMC2 CTSL LOXL2 ME2 FOS VEGFA LAMB3 LAMB2 ITGB1 LTBP1 LAMB1 HSPG2 SDC4 MAX LAMC1 SMAD1 ACTG1 DKFZp781O1323 TGFBI STAT3 AGRN PMC3068086__F7 Schematic overview of the network of enriched pathways related to HIV disease progression CASP3 BAD BAX PMC5315647__F7 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis POMC MC1R XPA ATR PMC3068086__F4 Coordinately up-regulated TCA cycle genes in CD8+ T cells from the VIR group (VIR versus LTNP) illustrated in TCA cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) SDHC OGDH ACLY SUCLG2 PCK2 HEL-S-32 MAPDA MDH2 PMC8251939__SF4 Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors BOC DCC PMC5315647__F9 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis ASIP XPA ATR PMC5587765__F3 IPA canonical pathway analysis and molecular activity of genes regulated by p53 in response to OT in differentiated SH-SY5Y cells BAD ROCK1 GADD45A GAS1 MAP3K5 TNF DIABLO ID1 HTRA2 DDIT3 CASP3 BIRC2 DFFA APAF1 PRODH CASP9 CASP8 CYCS BAX PMC7720404__F1 TF-miRNA-gene network CX3CL1 ESAM PAK4 GNG10 MYH10 KPNA1 STAT5B PRKCA SEMA4D E2F2 NKX2-5 DGKE RBL2 CCNE2 ROCK2 CLDN22 GNG5 USP45 ITGB3 SEMA4G RUNX1 CLDN10 CLDN16 PIK3R3 PS1TP5BP1 CALM1 PIK3R5 GNA11 PLCB4 PLCB2 NKX2-2 PPP3R1 PRKCB WASL GRB2 DUSP2 SOS1 CALML3 PPARG DKFZp781O1323 AKT3 STAT3 PMC1781924__F1 Thy-1-associated signaling pathways PI3 FYN ARHA SMAD1 LAT THY1 STAT3 PMC8505958__F2 Abnormal Airway Mucus Secretion Induced by Virus Infection IDO1 AHR EGFR SP1 TGFA IL1B TRPV1 STAT3 PMC10606123__F1 Underlying mechanism of histone deacetylases in regulating ovarian cancer metastasis HMGB1 HDAC3 FOXA1 KLF4 HDAC5 SIRT1 SIRT3 PMC4693276__F4 The synthetic lethality pathway model based on a deficiency in Alt-NHEJ and the double-strand break repair pathway POLE BRCA2 BRCA1 PMC3943304__F5 Activation of growth factor receptor protein tyrosine kinases results in autophosphorylation on tyrosine residues BAD MDM2 PTEN PMC7288517__F6 Mechanisms of accelerated aging triggering PD RBMS1 ADD2 B3GNT2 BCL6 FOXP3 PMC3943304__F6 Canonical and non-canonical JAK-STAT pathway and its subversion by BCR-ABL or mutant KIT KIT GAB2 CCND1 SRC MTOR PMC7288517__F5 Shortest paths for enrichment analysis of KEGG and BP ACSL6 ATL1-beta B3GNT2 IL12RB1 FABP1 BCL6 FOXP3 PMC9659971__F2 Immunometabolism in the tumor microenvironment and its related research progress GPR132 MYC TNF SLC16A3 PMC9659971__F3 Immunometabolism in the tumor microenvironment and its related research progress SIRT4 PCK1 RIPK3 FASN CD36 PMC4630370__F8 Proposed mechanism for NFKB signaling inhibition mediated by the antitumor peptide CIGB-552 BTRC SETD7 MAP3K7 TRAF6 ETHE1 SKP1 COMMD1 MAP2K6 ITCH PMC4931624__F1 The Wnt signaling pathway and possible points for therapeutic interventions to restrict S100A4-mediated tumor progression and metastasis APC GSK3B LRP5 LRP6 DKK1 S100A4 PMC9708673__F1 Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases PIK3R1 PLCL1 CLTA NCOR1 PDE4A P2RX7 TEC PLCG2 MEGF10 DNAJC6 HEL-S-26 SMC1A USO1 POLA1 PDE10A PTK2B FZD2 SHH SPTAN1 TRIO PLG APC PDE1A WNT10B TET2 RICTOR BRCA2 CLTC pp6425 BRD4 MYH9 PLCB3 IGF1R RUNX2 PDE5A DKFZp781B1423 PDE3A ITGA4 SLIT2 MTOR DNMT3B XBP1 RPTOR TLR4 KMO DSG1 ATM APP VWF ANXA1 TJP1 FGF6 OR2T12 OR52N4 GOLGA3 RAB6C NISCH GRIK2 C3AR1 CACNA1F SUPT6H RGPD4 CLVS1 PIK3C2B APOBEC3F SMPD4 COL22A1 EP300 KALRN SMC3 JAK3 CD93 STAT3 PMC5356908__F2 Immune cells in liver regeneration HEL-S-62p MYD88 STAT3 PMC4969639__F7 Proposed model for IFNGamma-induced apoptosis of HNSCC cells CASP3 ATF2 CASP9 JAK1 IFNG CASP4 PMC7139641__F3 Network of the most strongly dysregulated proteins of the glomerular ECM in FSGS HEL-S-78p HBB PMC8833116__F10 Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma AFP CCT7 PMC5160413__F1 RA pathway is differentially regulated in stem cells from VS and SC fat depots MGP CTSK PITX2 HOXA4 HEL-S-101 MEIS1 HEL-S-53e NR2F1 WT1 PTGS1 RARB TNC RARRES1 PLAT CDH6 CDKN2B ALDH1A3 ENPP2 F3 DHRS3 RDH10 ALDH1A2 MME PMC6022997__F3 Illustration showing presumed mechanisms mediating suberoylanilide hydroxamic acid (SAHA)-induced autophagy TIGAR ULK1 BAD BCL2 MTOR BAX PMC6954088__F8 The proposed mechanism for AAV9-shMyh9 against I/R-induced neuronal injury ROCK1 BAX PMC3786590__F1 Simple molecular pathway for sex determination in the mammalian gonads FST DHH RSPO1 AMH SF1 SOX9 FGF9 SRY PMC6172149__F1 Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity TFPI CX3CL1 CXCL10 CXCL9 IL6 TNF TF MAVS CXCL11 PMC3684179__F1 Cyclin D1 stability is regulated by ubiquitination-dependent proteasomal degradation USP2 CCND1 FBXW8 PMC6022997__F1 Autophagy, apoptosis, and cell cycle arrest mediated by the activity of nuclear p53 protein (p53) in its function as a transcription factor in stress conditions TSC2 ULK1 BAD MAP1B BCL2 MTOR DKFZp686F0183 BAX PMC6022997__F2 Autophagy and apoptosis mediated by the cytoplasmic activity of p53 protein under basal conditions TIGAR ULK1 BAD BCL2 MTOR BAX PMC3247643__F6 Overlay of significant canonical pathway and the connectivity in the molecular mechanism of cancer, with the eight genes in IPA canonical pathway and with the genes in Network (I) that differentially altered in PCB exposure CD46 TNFRSF12A ATP1B1 MGAT3 E2F5 PON1 PSMA2 SAA1 BCL2L11 ITGB1 IGFBP5 TAGLN CCND2 IL23A LDLR UNK BCL2 HEL-S-111 TGFB1 LAMC2 CP CD36 PMC3618688__F4 Resection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System CD14 TLR5 TLR9 RELB TRAF6 MYD88 TLR1 MAP3K7IP1 TLR10 TLR4 NFKB1 REL TIRAP PMC6794464__F2 Scheme of differentiation of M cells in PP SPIB MARCKSL1 RELA CCL20 RELB TRAF6 TNFAIP2 SOX8 HEL-S-7 PMC3786590__F3 Neuroendocrine control of pituitary and gonadal function GNRHR KISS1 KISS1R ARC FSHR PMC8117355__F1 Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer NDRG2 E2F4 VHL PARP1 BMI1 HEL-S-87p CBL NCK1 STAT1 PRC1 CDKN1A EZH2 BTG2 CP PMC9055624__F2 Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease PLCB2 EGF SRC ACE2 PMC3745819__F1 A CENTRAL ROLE FOR INDUCIBLE HEAT SHOCK PROTEIN 70 IN AUTOIMMUNE VITILIGO CD40 CD83 CD80 PMC5059430__F9 EtOH-induced BK channel internalization via Wnt/Beta-catenin signaling APC LRP5 LRP6 PMC7863132__F2 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease PLN MCU BAX PMC4631624__F1 Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer FAN1 PALB2 FANCD2 ATM BLM BRCA2 SLX4 BARD1 RAD51 FANCM DNA2 BRCA1 PMC7863132__F1 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease PLN MCU PMC7570055__F2 Cigarette smoke-related vascular irritation and activation in patients with COPD CXCR3 CCR2 CXCL10 LTB CXCL9 HDAC2 CXCL2 TGFA IL1B PMC8537160__F1 Wnt and Beta-Catenin Signaling in the Bone Metastasis of Prostate Cancer APC LRP5 LRP6 ARHA ROR2 CDC42 PMC5385559__F5 Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus TH RARA INA PMC12034266__F1 Sphingolipid biosynthesis and metabolic pathways UGCG SGPL1 DEGS1 CERK KDSR PMC8630440__F4 Proteomic analysis of human umbilical cord serum exosomes using mass spectrometry and preliminary study of their biological activities in liver cancer cell lines CD47 CD44 VWF CHAD PMC4120074__F7 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor BRAF ERBB2 ERBB3 NRG1 PMC8650380__F2 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications TLR4 NLRP1 MYD88 PMC8650380__F4 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications TLR4 VCAM1 MBP MYD88 PMC4120074__F2 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor KIT RICTOR LCK EGFR MSH6 GSK3A NRG1 PTEN MTOR BAX HEL-S-162eP PMC6932173__F6 Proposed inositol-requiring protein 1 alpha (IRE1A)-dependent mechanism of type I interferon induction upon proteasome impairment IRF7 EIF2A TRAF3 IRF3 PMC11893557__F2 Impact of autogenous and post-intervention gut microbiota on immune cells in HCC CXCL16 CXCL10 IL25 MTOR CXCR6 TF PMC12196557__F5 Interactive effects of prenatal Poly I:C exposure and antipsychotics on various signaling pathways and receptors in the dorsal raphe nuclei GAD2 CREB1 GAD1 TLR3 AKT3 PMC12092528__F4 RhoA/ROCK signaling pathway and Tau GSK3B RHO PTEN PMC8760698__F2 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension BMPR2 HEL-S-28 APLN MYC NOTCH1 PAH HMOX1 PMC3038181__F1 Activation of the PI3K/Akt pathway in cancer EGFR TRAF6 PTEN DEPTOR PMC3839612__F5 A detailed model of the Rad5-mediate template switch pathway, assuming gap filling dependent on a subset of HR functions after the replication fork has passed RAD51 RMI1 RAD18 PCNA PMC8979958__F3 Mammalian sirtuins and metabolic reprogramming SIRT2 SIRT7 SIRT4 SIRT5 SIRT6 SIRT1 SIRT3 GLS PMC8760698__F5 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension NLRP3 HMGB1 EIF2A BCL2 MTOR PAH PMC7779353__F10 Diagram of a signaling regulatory network that determines the AEC II differentiation phenotype ACE2 PMC3657316__F3 Ciliary signaling pathways implicated in control of cell proliferation GIG8 PDGFRA CDK2 PMC3160786__F1 mTOR signaling pathway The scheme depicts mTOR signaling cascade in the regulation of energy and growth factor-dependent translation and autophagy TSC2 ULK1 TSC1 ELF3 EIF4E DEPTOR RHEB PMC3160786__F2 Amino acids sensing of mTORC1 Rag-Ragulator-dependent mTORC1 activation in response to amino acid TSC2 RHEB PMC6641558__F3 The proposed pathway for constitutive AhR signaling and crosstalk with Src AHRR AHR SRC PMC7038996__F7 Two-step mechanism for SSB end resection in SSB repair and signaling.Step 1: An SSB is recognized by APE1, which then initiates SSB end resection in the 3′–5′ direction to generate a small gap (this work) SSB ATR PCNA PMC4051134__F5 Targeting JAK2 in the therapy of myeloproliferative neoplasms EPOR PIM1 PIM2 PMC6120446__F7 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood MYB ME1 BAD BCR MAFK MYCL SYK PTEN CLU CD19 PMC3334621__F7 IsomiRs and miRNAs target similar biological pathways BAD HIPK2 MAP3K7IP1 CRK ISL1 RS1 NF1 OCEL1 LEF1 MAX ATM HEL-S-11 CD2 GRB2 RAN ATR JUN FADD BAX PMC4051134__F3 Targeting JAK2 in the therapy of myeloproliferative neoplasms EPOR EPO PMC7721612__F9 RNA sequencing analyses reveal differentially expressed genes and pathways as Notch2 targets in B-cell lymphoma PPP3CA NCK2 NFATC1 FOS PPP3CC CSF2RB TNF MTOR PIK3R3 HSF1 RPTOR NLK SH2D2A NFKBIA LTA FYN BCR FZD2 SRC PIK3CA TRAF2 JUN NCF2 ELMO1 PMC6120446__F6 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood CD14 NLK DAO FLNA CRP TNF MEF2C MPL PMC7086007__F1 Pathogenic mechanisms of CRP causing inflammation and renal fibrosis in diabetic nephropathyCRP binds to FcGRII and activates the NFKB signal pathway to induce inflammation CRP MTOR PMC9321586__F3 Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation HEL-S-62p MAPKAPK2 SOCS3 STAT2 EBP IRF9 IRAK2 TRAF6 RAC1 MTOR MAP3K7IP1 IRS1 TSC2 MINK1 TSC1 CCND1 TAB3 PMC5668671__F2 Toll-like receptor signaling TLR5 TLR7 TLR4 TLR9 IRF3 MYD88 TLR1 TLR3 TIRAP PMC7086007__F3 NLR signaling pathways in diabetic nephropathyThe NLRP3 inflammasome can be activated by the ROS/TXNIP/NADPH oxidase signaling pathway and extracellular ATP, and inhibited by IL-22 NLRP3 CARD9 NOD1 NLRC4 IL22 TXNIP IL1B NOD2 PMC5668671__F5 HPVs infect host epithelial cells through TLRs EGF EGFR MTOR PMC2639789__F9 Summary diagram of E2 regulation of Wnt/Beta-catenin signaling pathway after cerebral ischemia and proposed role in E2 ischemic neuroprotection WNT3 GSK3B DKK1 JUN PMC12134342__F3 Tumor-associated neutrophil oncogenic mechanisms MPO FAM3C opn S100A8 IRS1 STAT3 PMC12134342__F4 Tumor-associated neutrophil tumoricidal mechanisms SIRPA CD47 HGF MPO QPCTL CXCL2 TRPM2 PMC3902172__F7 In vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis NOTCH2 DLL4 MSC NOTCH1 HES1 PMC12134342__F5 Interactions of tumor-associated neutrophils with other cells in the tumor immune microenvironment ARG2 IL1R1 CCL4 CXCL2 PANX1 PMC6797988__F6 Inhibitory effect of glycyrrhizin on ferroptosis during acute liver failure functions by promoting the Nrf2/HO-1/HMGB1 signaling pathway HMGB1 GPX4 TF PMC9445553__F6 Immune responses to different Uropathogens call individual interventions for bladder infection HBD EGFR CCL20 RNASE7 CXCL2 CCL2 PMC3225017__F2 c-MET signaling adaptors and mediators HGF GRB2 SRC CRK STAT3 CBL PMC3225017__F3 c-MET transactivation PI3 HGF GRB2 CD44 SRC PMC8146627__F1 Interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review TFPI PLG TF PMC10474868__F1 Polyhydroxylated Fullerene C60(OH)40 Nanofilms Promote the Mesenchymal–Epithelial Transition of Human Liver Cancer Cells via the TGFB1/Smad Pathway SMAD2 SMAD4 CDH2 PMC12098228__F2 Baicalein and baicalin significantly influences apoptosis in colorectal cancer cells MMP2 MMP9 CCNB1 CCND1 GADD45A PCNA BAX PMC11201817__F2 The influence of curcumin on mammalian DHA synthesis pathway and its neuroprotective effect [61] FADS2 IL6 TNF BDNF PMC12098228__F3 Baicalin inhibits colorectal cancer metastasis by targeting key migration and invasion pathways SOX2 CCNB1 CD44 CCND1 CDH2 CCNE1 BAX PMC5343289__F2 Crosstalk between autophagy and inflammatory signaling pathways: balancing host defence and homeostasis TBK1 CGAS ULK1 ATG16L1 NLRX1 MYD88 IFNG TUFM NLRP3 EIF2A JAK1 IL1B MAVS STAT3 PMC12098228__F1 Baicalein and baicalin suppressing proliferation in colorectal cancer MDM2 CCND1 CDK4 DKK1 MTOR PCNA BAX PMC6577427__F1 NAD+ salvage pathway in mammals NAMPT NRK PMC9408924__F5 Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning BAMBI E2F4 NODAL THSD4 SKP1 ARHA PMC10740672__F8 Growth suppression mediated by p53 TSC2 TSC1 PTEN RHEB PMC10973673__F1 Crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy E2F4 APC E2F5 GSK3A SSBP1 CDK6 WEE1 ATM CDK2 CDK4 CDC2 ATR SIRT1 PMC7878365__F3 Sestrin modulates cell signaling networks in physiological responses to environmental stresses ULK1 SESN3 KEAP1 ATF4 SMAD2 EIF2A SMAD4 SESN1 SESN2 XBP1 PMC3205232__F1 A brief survey of mRNA surveillance DCP2 DCPS NUDT16 RAI1 PMC5782799__F5 Gene interaction network UBC PTMS CCNA2 ZBTB16 ZZZ3 ZDHHC13 IL4 PMC9157790__F2 Wnt Signaling in the Breast: From Development to Disease ZNRF3 RNF43 APC GSK3B LRP5 LRP6 DKK1 GPR49 WIF1 PMC3321453__F6 Vitamin D pathway and sites of interaction with dietary factors NR1i1 CYP24A1 PTH PMC6081565__F1 Two classic pathways of necroptosis TRADD TNF MLKL PMC9157790__F4 Wnt Signaling in the Breast: From Development to Disease DKK3 LRP5 FZD7 LRP6 SFRP1 DKK1 GPR49 RSPO4 WIF1 LGR6 SFRP5 DKK4 PMC9445553__F4 Immune responses to different Uropathogens call individual interventions for bladder infection TLR4 RNASE7 HMGN2 NOD2 PMC9405604__F4 Depletion of Mdig Changes Proteomic Profiling in Triple Negative Breast Cancer Cells OS9 ELF3 EBP RPS6 ELF4 TRAF2 PMC5800786__F4 Metabolic Regulation of Immune Responses IL7R TRAF6 MTOR PMC4428658__F3 Eculizumab and Recurrent C3 Glomerulonephritis C9 C7 C6 PMC4731654__F3 Wnt signaling pathway LRP5 LRP6 PMC8450343__F6 Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects HAVCR2 IFNGR2 IL6 TNF IL5 IL12A IL12B IFNG STAT1 IL18 IL7 TBX21 CD27 IL27 IL2 BCL2 CD40 CSF2 CSF1 IFNGR1 PMC4624297__F4 Comparison of typical innate immune signaling cascades (top panel) with those activated by CJD infection (bottom panel) STAT1 ISG15 STAT2 IRF9 CXCL10 IRF3 IFNAR2 IFNAR1 MX1 PMC4650800__F5 Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling MMP3 MMP9 TGFB1 PMC7999177__F2 Transcriptomic alteration-based identification of potential diseases and functions modulated upon leptin upregulation IL1A CCL11 CTSK CXCL5 PTGS2 MMP9 LCN2 IL6 SAA1 MMP3 LEP MMP12 FGF7 PMC3349255__F7 Schematic diagram of a cross-regulation network between FOXA1 and the ErbB2 signaling pathway in ER-negative breast cancer TLE3 PAK1 FOXA1 ERBB2 FOS RELB CREB1 PMC2712597__F6 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways RHD MOCS3 URM1 PMC4498776__F6 Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs CD14 EGF MOS PPP3CA NFIB ATF2 EGFR GCK TRAF6 TNF SIX4 ATF4 ECSIT TRAF2 IL1B CR1L PMC2712597__F1 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways UFM1 SUMO3 ISG15 GABARAPL2 ATG12 ATG3 UBA6 NEDD8 GABARAP SUMO1 PMC7354691__F4 Interaction network downstream of Atoh7 HELLS PRPF38A CTTNBP2 RSRC2 MRPL43 BOP1 WASF2 CISD1 NME6 PAPOLG COPA NELFA TRMT61A IPP COL1A1 ATOH7 COX17 ZNF217 SYMPK SMC2 PMC7503925__F6 Pigment-type switching controlled by dual signaling from MC1R MGRN1 ASIP MC1R PMC3124513__F6 Integrated Bio-Entity Network: A System for Biological Knowledge Discovery FPR1 TPM3 PTK2B IL2 CEBPA KCNK3 PMC3960869__F2 Interaction of Neisserial surface molecules with the complement system HEL-S-62p C9 C7 C6 PMC4073605__F7 Proposed model for the formation of reactive oxygen species at mitochondria, activation of Nrf2, and regulation of phase 2 gene expression in the nucleus MAF PI3 KEAP1 PMC2768581__F2 Role of Cross Talk between PI3-Kinase and ERK/MAP Kinase Pathways in Artery-Vein Specification FOXC1 SHH EPHB4 PMC2858157__F6 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration SLC9A3 TRAF3 ZNF274 ZNF675 RAD18 BRCA1 CCNO CHEK2 MCM6 TCERG1 GABPB2 FRS2 JUN AIM2 FADD MZF1 TRIOBP PMC5980236__F1 Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells MVK IPP MVP PMC3747497__F1 FGF signalling: diverse roles during early vertebrate embryogenesis FRS2 GAB2 GRB2 SRC PMC2858157__F7 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration DNAJB4 BRAF BRIP1 LATS1 TMF1 BCCIP BRCA1 DTL EIF1AD POLR3E NPAT LCMT2 PELO RPS25 HNF4A PERP KIF20A PYHIN1 TCF21 ELL PMC2858157__F8 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration CASP3 CLSPN CCNA2 DDX11 HDAC3 CDC6 E2F2 PRIM2 EMP1 AURKA PMC2858157__F9 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration CLSPN CCNA2 HDAC3 EPO CDC6 E2F2 DNAJB6 PRIM2 EMP1 DTL PCNA FZR1 PMC6930397__F5 Functional protein interaction network of PLOD family genes SPARC ADAMTS2 BMP1 COL3A1 ADAMTS3 PLOD1 PCOLCE FBN1 SOX9 PLOD2 DCN CRTAP COL14A1 COL16A1 MMP2 PCOLCE2 COL12A1 COL9A2 PLOD3 PPIB COL9A3 COL9A1 PMC2592809__F9 Scheme summarises different intracellular pathways during osteoblast differentiation which include promoting (blue) and inhibiting (red) factors and are mainly mediated by Smad proteins WNT3A RUNX2 BMP2 EBP HEL-S-11 SMAD6 MSX2 DLX5 SKI ACTR2 DLX3 PMC4654378__F2 NOX system is central to host defense NLRP3 VCAM1 DUOX2 NOX4 CSA2 IL1B NOD2 NDP PMC9231311__F4 Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants COX1 GSDMD IFNG PMC6363620__F3 Complex interplay between CCT and actin and tubulin DYNAP PMC12243265__F9 RGCs damage in glaucoma were ameliorated via Gut microbiota-IAA-eye signaling pathway AHR IL6 IL1B PMC5323256__F8 Glycogen Synthase Kinase-3B Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 IGF1 NGF GSK3B PMC4820873__F6 Schematic model of IGF1R-evoked and p110Beta-evoked resistance to p110A inhibition in PIK3CA mutant breast cancer cells IGF1R IGF1 PIK3CA MTOR IRS1 PMC3562627__F2 EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer BRAF EGFR PMC4381257__F1 Important ECM molecules and ECM receptors involved in cancer cell invasion MMP2 HEL-S-28 MMP9 CD44 RHO PMC6724557__F1 TNFR2 can modulate TNFR1 signaling TRADD TRAF2 FADD PMC6724557__F3 Model of TNFR2-mediated regulation of NFKB transcriptions factors in Tregs RELA RELB TRAF2 PMC6768886__F7 MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/Beta-catenin signaling LEF1 LRP5 FZD7 LRP6 PMC2374711__F5 Proposed model of APL pathogenesis induced by PML-RARA PML ETV4 ATF1 STAT5B RARA ACTL6A NFYC ARID5B SND1 NFYA MYBL2 EGR1 USF1 RUNX1 FOS FOXO1 RXRA BCL6 UBTF BCOR LEF1 TCERG1 SPIB EGR2 STAT4 RORA CHD9 PMC9250635__F1 CGAS activation and cGAS-STING signaling TBK1 CGAS IRF3 PMC9250635__F2 CGAS activity in cells CASP3 CGAS PQBP1 TREX1 ZCCHC3 CASP5 CASP4 PMC3649977__F2 STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification C6 BCL2 BAX PMC6542701__F2 ER’s coregulatory proteins and genomic binding sites differ between endometrial cancer and breast cancer cells FOXA1 ETV4 GREB1 TF GATA3 PMC5549027__F15 Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway MTOR BAX PMC11502381__F2 Bidirectional regulation of the cGAS-STING pathway and immune cells in the tumor immunosuppression microenvironment (A) The cGAS-STING pathway inhibits M2 macrophage polarization and promotes anti-tumor immunity CGAS CCR2 TFEB CCL7 CCL2 NOS2 STAT3 FOXP3 PMC8657039__F2 Early TP53 Alterations Shape Gastric and Esophageal Cancer Development WEE1 ATM ATR PMC5442340__F4 KEGG pathway for Hippo signaling pathway AFP SOS2 AMOT AREG MYC LATS1 RASSF6 LATS2 PMC7263595__F1 Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 COQ7 PMC5442340__F5 KEGG pathway for PI3K-Akt signaling pathway BAD CD37 MEI1 MYC PTEN RAC1 MTOR RXRA TSC2 PI3 BCR GRB2 RBL2 PMC5082287__F3 Pathway depicting Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes identified in the present analysis, which could directly or indirectly affect skeletal muscle cell functions ZFP91 ITGB1BP2 TAGLN3 F2R MYF5 FADS1 SAA1 MEF2C LAMA5 SVIL HACD1 DMD PMC6981772__F2 Plant sterol and cholesterol metabolism ABCB4 APOO LPL APOE ACAT2 PMC4631354__F3 Characterization of SCDs as Membrane Maintenance Regulators FAT2 FAT1 FAT3 FAT4 PMC5082287__F5 Relevance network over-viewing discussed relationships between Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes and cell processes (Pathway Studio Web Mammalian) ABHD5 NOS2 ESRRA DMD PMC9369281__F2 MicroRNAs in Inflammatory Bowel Disease and Its Complications PDLIM2 PTEN SOCS1 STAT3 PMC5539204__F6 Complexity of the miRNA-mRNA interactome network in rat soleus muscles with cardiac cachexia COL22A1 SMOC2 TLN2 MMP16 ITGB1 PMC4107940__F1 General interplay between the canonical TLR signaling pathway, the cytokine-mediated DNA repair feedback loop, and the growth factors-mediated signaling pathway HMGB1 MYD88 BRCA1 XRCC5 STAT1 STAT4 GRB2 TYMS RAD51 ERCC1 XPA OGG1 TIRAP STAT3 MAL PMC7470101__F1 Role of cytokines in mediating communication between immune cells IL10 IL13 IL24 IFNB1 IL6 IL25 IL5 IFNG IL15 IL26 IL18 IL7 IL3 IL27 IL22 IL2 IL-21 IL4 IL20 PMC8247566__F2 MiR-126 pro- and anti-angiogenic function in different cell-types S1PR2 VCAM1 RPE PIK3R2 PMC3448682__F7 Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis OAS1 PIM1 OAS2 TRAFD1 IL15RA CD40 IFNB1 TNFAIP2 GBP4 UBE2L6 MEFV PMC10985261__F12 The VDR-mTOR Signaling Pathway in DKD Development NR1i1 MTOR DDIT4 PMC4676991__F2 Autophagic signaling pathways associated with oxidative stress TSC2 ULK1 TSC1 ATM FOXO3A PTEN UVRAG BNIP3 PMC7098960__F2 The immune response induced by polygenic diseases related to the composition of the intestinal microbiota in patients with IBS and healthy subjects TLR7 TRAF6 TYK2 MGAT5 IL23R IL10RA NOD2 IL12RB1 TIRAP STAT3 PMC8058464__F1 Transcriptional signature of Leishmania infected macrophage IL4 MTOR SIRT1 PMC6057036__F7 RASAL2-mediated hippo signaling pathway YAP1 CCND1 LATS1 LATS2 PMC6836336__F3 GREM1 expression is associated with genes involved in collagen formation and extracellular matrix (ECM) organization SPARC ADAMTS12 ANGPTL2 TNFAIP6 POSTN ADAM12 FBN1 NOX4 GLIS3 MMP2 FAP MSRB3 P4HA3 PRRX1 LOXL2 ADAMTS2 BMP1 CTSK AEBP1 FOXF2 GLT8D2 SRPX2 VCAN DPYSL3 PDPN RARRES2 CTHRC1 TAGLN MMP14 THBS2 INHBA PMC9598787__F7 Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation SOCS3 TRADD MCL1 PMC4254277__F2 Protein and Amino Acid Restriction, Aging and Disease: from yeast to humans ATF4 MTOR PMC11011407__F2 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies FGFR1 FGF2 RRAS RAC1 MTOR EPHA2 EPHB2 CDC42 EPHA4 PMC11011407__F3 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies EPHB1 CDK4 EPHB4 EPHB2 PMC11011407__F4 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies EPHA7 EPHA2 PMC6403468__F13 Model of ApoER2 and VLDLR mediated signaling during cortical development DAB1 DCC CP PMC3897553__F8 Neural Epidermal Growth Factor-Like Like Protein 2 (NELL2) Promotes Aggregation of Embryonic Carcinoma P19 Cells by Inducing N-Cadherin Expression CDH2 SP1 PMC10526485__F2 Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases EFHA1 MICU1 MCUB MCU MICU3 PMC7294139__F3 Gene ontology and pathway enrichment and network analysis of blue module genes COL22A1 DCN MMP14 P4HA2 COL3A1 THBS2 POSTN VCAN TIMP3 PCOLCE CXCL12 TGFBI PMC11016919__F1 Trimetazidine May Potentially Confer Neuroprotective Effects against COVID-19-Induced Neurological Sequelae via Inhibition of Death-Associated Protein Kinase 1 (DAPK1) Signaling Pathways: An Evidenced-Based Hypothesis PTEN BDNF BAX PMC6694821__F6 Protein interactome of genes downregulated upon productive HPV16 infection of epithelial tissue types RIT1 NDRG2 NDN JMY PLCG2 SAA1 TM7SF2 HEL-S-26 VAV3 OAS3 FYN TCN1 B2M F11R PTK6 MMP10 COL18A1 IRF7 IRF9 ERBB3 LCN2 UGDH HBEGF RGS2 HLA-A NFKB2 CCL20 NR1C2 PRKCH TGFA DHRS9 CXCL1 CALB2 MX2 MX1 ISG15 SP110 OAS1 XAF1 OAS2 AMFR MYO6 FLG CTH MAFF PTGES CGA SERPINE2 VLDLR TNFSF10 ST3GAL1 IL18R1 AMACR GAS7 IFITM2 ALOX12 SLPI SP100 PLA2G7 OASL GPX2 KLK3 FOSB EPHA1 PCK2 BTG2 S100A4 LAMC2 GPNMB NAMPT RSAD2 HFE RPTN SPNS2 GAST PTHLH YOD1 LCE1E HLA-F RNF144B LCE1D LYPD2 IL36RN HELZ LYPD6B TMPRSS11D TNFRSF21 SMOX HEL-S-52 TPD52L1 TJP3 RORA SLC40A1 IFIH1 IFIT1 IFIT3 INA HLA-G NLRP2 TYMP PPBP UBC IL36G GAL CGN IL1B CLDN1 BST2 PARP1 PDK4 hCG_1998026 FUT3 GAB2 ASNS ERN1 MAP3K8 PMC7423683__F4 Notch and the Regulation of Osteoclast Differentiation and Function NOTCH2 NOTCH1 NOTCH3 IL1B HES1 PMC12045470__F5 Sepsis-induced liver injury GPX4 TLR4 HEL-S-44 PMC12045470__F6 Sepsis-induced myocardial injury NLRP3 HMGB1 GPX4 TLR4 NOX4 PMC12045470__F3 Sepsis-induced lung injury NLRP3 TLR4 FTH1 HMGB4 TNF PMC12045470__F4 Sepsis-induced kidney injury NLRP3 GPX4 TLR4 SLC7A11 NOX4 HEL-S-44 PMC9324529__F1 Immunosuppressive Mechanisms in Brucellosis in Light of Chronic Bacterial Diseases TLR8 TLR4 EGFR CD80 PMC8899123__F3 Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes OXCT1 SUFU SHH SKP1 SMO MTOR SKP2 PMC4099420__F6 Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis DGIC IFIT2 TLR9 TRIM21 EIF2AK2 MYD88 MX1 OASL OAS1 OAS2 OAS3 TLR7 IFNGR1 AIM2 c-fgr IRF7 IRF8 ADAR APOBEC3F ISG20 SYK IL27RA IFIH1 TRIM5 APOBEC3G SOCS1 IFIT1 PMC8017232__F7 Proposed model depicting the involvement of TIPE2 in the RIG-I signaling pathway TBK1 IRF3 MAVS PMC12045470__F2 Protective mechanism of dexmedetomidine against multiorgan dysfunction NLRP3 HMGB1 TLR4 NOX4 HEL-S-44 TNF MTOR GSDMD BAX PMC10374575__F6 GHS-R1a/D2R heterodimers activation in dopaminergic neurons TH GAL PMC4179756__F13 Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27 HTRA2 PMC4071201__F1 Depiction of the systematic procedure to study drug resistance in MM MAP3K1 TLR4 IGF1 EGFR GRB2 MAP3K7 TRAF6 MTOR TGFA TRAF2 IRS1 BAX PMC4071201__F2 p38 MAPK isoforms for drug resistance PC SHE MTOR IRS1 RAI1 BAX PMC8498061__F2 Myricetin: A comprehensive review on its biological potentials EGF HIRA EGFR MTOR STAT3 PMC9201453__F2 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases MMP3 PIM1 CDK2 SMAD2 DIO1 SP1 TGFBI PMC9201453__F3 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases NDRG2 PDGFA TRIP13 THRSP PMC7056742__F2 Activation of NLRP3 inflammasome has involved in the pathogenesis of several renal diseases including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN), IgA nephropathy (IgAN), etc NLRP3 IL1B FADD PMC4620942__F5 Modeling the calcium-mediated pro-apoptotic action of less toxic natural products ATF4 EIF2A DDIT3 INSR PMC10520667__F7 LncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death ULK1 BMI1 MTOR PMC4184083__F1 Addition of RASAL1 to the canonical scheme of the RAS-coupled MAPK and PI3K pathways BRAF PTEN MTOR RASAL1 PMC4601496__F1 Manipulation of neutrophil function by P MYD88 MAL PMC3627065__F8 Factors situated at the interface between the ubiquitin-proteasome and the autophagy-lysosome degradative systems BAG3 MTOR BAG1 PMC3627065__F6 Integrated view of mammalian autophagy ATG12 ATG3 AMBRA1 BCL2 UVRAG ATG10 ATG14 DKFZp686F0183 PMC3829803__F7 Retinoid action during paramyxovirus infection IRF7 IRF9 IFNAR2 IFNAR1 IRF-1 MAVS PMC3954580__F5 MEK5/ERK5 Pathway: The first fifteen years EGF BAD FOXO3A LIF SNAI2 SRC IL6 CDH2 MEF2C STAT3 PMC9266688__F8 Tumor-Suppressor Role of the A1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma EGFR SRC MTOR FOXO1 PMC6377309__F1 SAMHD1 down-regulates the IFN-I pathway TBK1 CGAS RIGI IRF3 PMC6377309__F2 SAMHD1 prevents the activation of NFKB signaling RELB TNF IRF-1 PMC1764624__F1 Synthesis and breakdown of proteins by amino acids EIF4E MTOR IRS1 PMC6377309__F5 Role of SAMHD1 in the crosstalk between innate and adaptive immune responses APC PMC10222038__F1 Vitamin D metabolic pathway CYP2R1 MOK CYP27B1 PMC4543607__F1 Major EDCF-mediated signalling pathways in hypertension and diabetes COX1 RHO PMC8479196__F3 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy LPO FASN CD36 PMC8479196__F1 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy MSC FASN CD36 PMC3091682__F2 Correlation of Predicted miRNA Targets with Hosts BAD PTEN RB1 MTOR FOXO1 MAP2K1 PDGFA CDK2 MDM2 GRB2 CASP9 SRD5A2 CSA2 PMC9513149__F1 DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology ATM CDK2 CCND1 CDK4 ATR CDK6 GATA4 PMC9201453__F4 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases TRIP12 USP18 PMC4177605__F3 PPAR signaling pathway from KEGG UBC PLTP UCP1 LPL PMC3954580__F2 MEK5 regulation and downstream targets EGF BAD NGF FOXO3A FOS ZEB2 LIF SNAI2 SRC IL6 BDNF PMC5352205__F8 Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness BRAF MMP9 PMC5863775__F1 MST2-RASSF protein–protein interactions through SARAH domains MDM2 LATS1 LATS2 ARAF PMC8694249__F1 Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism PSAT1 PSPH GLDC PTEN PHGDH PRL PMC4162761__F1 Biosynthesis and Roles of Phospholipids in Mitochondrial Fusion, Division and Mitophagy CDS1 PC GPAT2 GPT2 PGP PMC5325784__F2 HPV E6 and E7 interacts with core components of the interferon pathway CGAS TANK STAT2 IRF7 IRF9 TRAF3 IRF3 IFNAR2 IFNAR1 STAT1 HEL-117 JAK1 IRF-1 PMC6423448__F1 Key components of the Hippo pathway in Drosophila and mammals NF2 LATS2 PMC6006200__F2 Fe/S cluster biogenesis CFD PMC2886068__F2 Bile salt synthetic pathways CYP27A1 CYP7A1 HSD3B7 PMC7568356__F3 CircRNA-miRNA-mRNA networks in hematological malignancies FZD3 CCND1 PMC3387579__F1 De novo DAG/TAG synthesis (Kennedy pathway) DAG1 LPA PMC6691039__F1 Platelet Theory SYK LAT PMC4018451__F1 The IRS-1→PI3K→Akt insulin signaling pathway TSC2 BAD FOXO3A PDK2 PTEN IRS1 PMC4018451__F2 Schematic summary of hippocampal formation alterations in the IR→IRS-1→PI3K→Akt→mTOR signaling pathway of AD dementia cases versus age- and gender-matched controls TSC2 TSC1 PDK2 GSK3A PTEN MTOR IRS1 PMC6691039__F2 Endothelial theory VWF PMC8460702__F5 Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2–YY1 signaling pathway PCK1 YY1 BTG2 PMC5346332__F3 Role of Aim2 protein in non lupus-prone and lupus-prone strains of mice in the regulation of type I IFNs production TBK1 IRF7 IRF9 IRF3 IFNAR2 IFNAR1 AIM2 PMC8034456__F8 The beneficial effects of FGF19 on muscle atrophy, metabolic homeostasis and irisin secretion in skeletal muscle NRF1 UCP1 FGF19 IRS1 TFAM MYOG PMC8155122__F3 Biased signaling of oxycodone and morphine HEL-S-34 EGFR TRPV1 PMC7198830__F1 Direct cardiotoxic effects of anti-cancer therapies in cardiomyocytes ERBB4 BAD ERBB2 SRC MTOR PMC9060002__F7 Data suggest multiple potentially active epithelial–mesenchymal transition-associated pathways in CF, with YAP1 mediating their crosstalk LEF1 HSP90AB1 S100A8 MYC HEL-S-133P CFTR PMC9706580__F8 Mutant Kras and mTOR crosstalk drives hepatocellular carcinoma development via PEG3/STAT3/BEX2 signaling TSC1 MTOR PEG3 BEX2 STAT3 PMC5346332__F1 Constitutive low levels of IFNB that are produced by most cell types “prime” type I IFNs producing cells for a robust type I IFNs production upon sensing “danger” signals such as cytosolic DNA and TLR ligands TBK1 STAT1 CGAS STAT2 IRF7 IRF3 TYK2 IFNAR2 IFNAR1 PMC10594068__F3 Bone is a tissue that consists of diverse cell types (osteoblasts, osteoclasts) that interact in a complex manner PTH1R MSC PTH PMC6094638__F3 Anti-inflammatory function of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF3 in toll-like receptor (TLR) signaling pathway RELA TRAF3 TRAF6 MYD88 PELI1 MAP3K7IP1 TRAF2 TAB3 PMC4148386__F3 MAPK signaling pathway CD14 NLK MAX RASGRP3 FLNA TGFBR1 TGFB1 PMC8327900__F1A What Are the Clinical and Systemic Results of Periodontitis Treatment in Obese Individuals? ADIPOR1 ADIPOR2 NR1C1 INSR APPL1 PMC6407861__F1 Assembling a protective shield ME2 RIF1 SHLD3 SHLD2 SHLD1 BRCA1 PMC8928443__F4 Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations PC MAP2K4 PTEN MYD88 STAT3 PMC6094638__F1 Function and regulation of tumor necrosis factor receptor-associated factor (TRAF)6 in MyD88 signaling pathway USP4 CYLD OTUD7B USP20 TRAF6 MYD88 MAP3K7IP1 TAB3 MYSM1 PMC7125957__F1 B9 metabolism comprising the thymidylate cycle (red diagram), the methionine cycle (green diagram) and the purine biosynthesis pathway (blue diagram) VIT DHFR PMC7125957__F2 Vitamin B6 metabolism in humans HEL-S-302 HEL-S-1a PNP PMC10966134__F8 Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI ATF4 EIF2A DKFZp686F0183 PMC6657611__F2 Notch-targeting therapeutic approaches in TNBCs NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC5138043__F2 FAT4 participates in tumor transformation through the Hippo–Wnt signaling pathway by inducing YAP–TAZ activation.Notes: Src-mediated tumorigenesis also results from Src activation to repress FAT4 gene expression via MEK/ERK or cofilin1 APC SRC FOXK1 FAT4 PMC8216017__F1 CXCL12 in Kidney Diseases: A Friend or Foe? CXCR4 SHH CXCL12 PMC8216017__F2 CXCL12 in Kidney Diseases: A Friend or Foe? BAD DPP4 CXCR4 TEC CXCL12 PMC9004567__F5 Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine KDM7A CHUK HGF INS MYC MTOR ITK IGF1 opn CHAD ITGAV JAK1 CXCL12 PMC7201649__F10 Copper Induces Oxidative Stress and Apoptosis in the Mouse Liver AHR TRADD TNF FADD PMC9001970__F1 Evolving Roles of Notch Signaling in Cortical Development NOTCH2 NOTCH4 JAG2 NOTCH1 NOTCH3 PMC3544113__F1 Main deregulated signaling pathways in PMBCL MAP3K14 TNF SOCS1 PMC6584414__F1 Schematic illustration of albumin nanoparticles preparation and their targeted delivery to breast cancer cells and metastatic lymph node SPARC NPS SMO PMC6367250__F1 The roles of circRNAs in cancer phenotypes and biological characteristics FOXO3A TIMP3 PMC4894443__F4 Flatworms have lost the right open reading frame kinase 3 gene during evolution LTV1 RIOK2 RIOK3 NOB1 PMC5240838__F8 Proteostasis network via the HSF1-SQSTM1 axis TBK1 SQSTM1 HSF1 PMC6944215__F5 Representation of the adverse outcome pathway (AOP) network involving BPF CCND1 CDK4 CDK6 GPER PMC10384765__F6 Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus SOCS3 IFNA4 STAT2 FOS IRF9 TRIM21 IRF3 IFNAR2 TRIM25 TRIM26 IFNG AHR TRIM38 IFNK IFNA2 IRF2 IFNA17 PMC10474147__F2 Necrosis and apoptosis: morphological features and signaling pathways CASP3 TRADD CASP9 CASP10 CASP8 FADD BAX PMC3941921__F3 Highest-scoring downregulated network: Energy Production, Metabolism and Cell Structure CAMK2D HEL2 HEL-S-1 ATP1A1 SLC8A1 SLC25A4 HEL-S-93 PFN1 PMC3941921__F5 Downregulated network of CANB1 in traumatic brain injury (TBI) PPP3CA PPP3R2 PMC6678366__F4 Molecular mechanism of soft-jet plasma-induced cancer cell apoptosis via the mitochondrial intrinsic pathway and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activation H2AX BAX PMC7667085__F1 Pseudomonas aeruginosa injection (PAI) make the naïve T cell mature through both CD80/86 and MHC-II signal pathway in dendritic cells (DC) CD80 PMC2788936__F3 Signaling and regulation of PRR-induced autophagy IL18 TLR4 MYD88 PMC3941921__F2 Highest scoring upregulated network: Cellular Assembly MYH9 INA MAP2 PLEC ERMN NEF3 NEFH SYN1 HEL113 LMNA NEFL PMC11484394__F2 Diagram illustrating the regulation of the p53 pathway by miRNAs in prostate cancer (WP3982) PTEN CYS1 MTOR CASP3 CHEK2 SIAH1 IGF1 PERP SESN3 ATM APAF1 BBC3 PMAIP1 MDM2 CASP9 ZMAT3 TP53AIP1 CASP8 BAX PMC3784162__F2 Toll-like receptor 3 (TLR3) participates in both defence and offence in host immunity to viruses TRAF3 TRAF6 IRF3 TRAF2 TLR3 PMC4891224__F1 Is There a Future for AKT Inhibitors in the Treatment of Cancer? TSC2 TSC1 CCND1 PTEN RPS6 IRS1 PMC2784308__F1 An illustration of the MC1R pigmentation pathway and the loci implicated in melanoma risk ASIP TYRP1 MC1R PMC5399014__F6 Metabolic pathway of lipid accumulation in oleaginous microorganisms and related key enzymes CS PMC4915479__F4 Major TGFB signaling pathways in vascular cells LEF1 CDK2 ATF2 SMURF2 GSK3B GRB2 TRAF6 TBR1 ENG NET1 RHO PMC7277712__F6 Bisphenol A-induced synthesis of steroids: The bisphenol A (BPA) spreads out through the membrane and binds the cytosolic multi-protein aryl hydrocarbon receptor (AhR), allowing its release in the cytoplasm by the heat shock protein (hsp)-90 AHR PBR STAR PMC3304564__F1 PI3K/AKT signaling module and cross-talk with other pathway TSC2 PTEN RHEB BAX PMC5846438__F2 Signaling pathways of different amino acids in intestinal inflammation CASR MTOR ACE2 PMC2905406__F10 Illustration of GDNF signaling disruption by coated silver nanoparticles PI3 RET FYN GDNF PMC5846438__F1 Possible signaling mechanisms of amino acids in intestinal inflammation in the ECs are illustrated CASR MTOR ACE2 PMC3658307__F2 Liver Ischemia and Reperfusion Injury: New Insights Into Mechanisms of Innate – Adaptive Immune-Mediated Tissue Inflammation CXCR3 HMGB1 TLR4 TLR9 CD1D CXCL10 STAT4 CXCL8 CD40 CCL2 IL1B PMC7396796__F1 Model representing the molecular signaling pathway of WAVE3 contributing to cancer progression and metastasis EGF SMAD2 RAC1 PMC10886137__F4 JNK and p38 MAPK signaling pathway of filefish upon Cd exposure TRADD IL2 IL11 JUND MYD88 TNF TRAF2 PMC8953253__F4 Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator WNT16 SOST GRB2 JAK1 OSM OSMR STAT3 PMC10886137__F5 Glycolysis pathway of filefish upon Cd exposure HEL-S-49 ENO1 ENO2 GCK HK2 HEL-S-162eP PMC10886137__F6 Fatty acid degradation-related pathways of filefish upon Cd exposure CPT2 ACD PMC10886137__F7 Citrate cycle (TCA cycle) pathway of filefish upon Cd exposure SDHD DLAT SDHA MDH2 SDHB PMC8914342__F3 Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases ELAVL1 TFF1 IMPACT CTCF MDM2 PARP1 PMC1386115__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs TLR4 COX1 MMP9 ABCG1 IRF3 ABCA1 TNF IL1B NOD2 TLR3 PMC9103147__F3 Proteostasis Perturbations and Their Roles in Causing Sterile Inflammation and Autoinflammatory Diseases CGAS MDM2 IRF3 CGA PMC6024333__F2 Mechanisms of innate and acquired resistance to immune-checkpoint inhibitors (ICPIs) JAK1 PMC7528619__F2 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 CGAS DDX41 IRF3 IFI16 PMC7528619__F3 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 IFIT3 CH25H IRF9 TYK2 IFNAR2 IFNAR1 LAT PMC6627600__F1 Interactions between RHOB and EGFR, Ras, PI3K/Akt/mTOR, MYC, and HDAC EGF EGFR MYC GRB2 PTEN MTOR TGFA HDAC1 RHOB PMC7249724__F3 Micro-environment favorable for re-pigmentation PC SMAD4 MC1R PAX3 PMC10743093__F3 Schematic illustration highlighting targets of senotherapeutics including senolytics and senomorphics FOXO4 MTOR GPNMB PMC5749411__F4 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development BAD AIP TRADD ATM MYD88 TRAF2 FADD BAX PMC7531836__F1 Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease HEL-S-62p CD59 C9 FH C7 C6 CR1 PMC5749411__F5 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development NODAL PITX2 SMAD2 SMAD6 SMAD4 ARHA RBX1 SMURF1 BMP4 IFNG FST SI SMURF2 TGFBI PMC2396493__F1 P53 on the IGF-1 signaling pathway RICTOR IGF1 PTEN MTOR PMC8348034__F6 Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells HMGB1 IL6 IL1B PMC8450413__F5 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer APC PORCN PMC2821977__F1 All steroids derive from cholesterol, which can be synthesized within the brain for de novo neurosteroidogenesis () CYP11A1 PBR STAR PMC9685566__F9 Transcription level differences in Taxus wallichiana var. mairei elicited by Ce3+, Ce4+ and methyl jasmonate MOS FLNA RAC1 RAF1 CDC42 PMC5442293__F1 Role of WIP1 phosphatase in termination of DNA damage response CDKN1A ATM MDM2 CDC25B ATR PMC7007436__F7 Pten-mediated Gsk3B modulates the naïve pluripotency maintenance in embryonic stem cells GSK3B PTEN MTOR PMC6698381__F3 Pathways involved in sphingolipid metabolism SGPP1 SMPD2 GBA2 SPHK2 ASAH2 SGMS1 UGCG ACER1 ACER3 SMPD1 SPHK1 DEGS1 SGMS2 PMC6471604__F1 Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis MUC1 MUC13 MEI1 HGF EGFR CCND1 AXIN2 MUC15 STAT3 BAX PMC8686517__F1 TNFA in MS and Its Animal Models: Implications for Chronic Pain in the Disease RIPK1 TRADD TRAF1 RIPK3 TRAF2 FADD MLKL PMC6425566__F3 Mitonuclear communication EGR1 EPO PARP1 GRSF1 SIRT1 PMC8450413__F1 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer ZNRF3 RNF43 CDK14 APC GSK3B LRP6 GPR49 PMC8450413__F2 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer DAAM1 ATF2 ARHA RYK JUN CDC42 PMC6441546__F4 One-carbon metabolism AS3MT MTR HEL-S-20 GAA SLC19A1 PMC8450413__F3 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer SMAD2 APC TGFBR1 GSK3B LRP5 TGFBR2 LRP6 SFRP1 SMO DKK2 PMC11042222__F4 Loss of Ffar4 is associated with decreased AMPK signaling and increased cellular senescence in the infarcted myocardium HLA-G TRPV4 CD82 INS MCU PTEN MRE11A GATA4 ATM CDK2 RAD50 CDK4 ATR CIDEA POC1A PMC8450413__F4 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer MYC ADAM10 ADAM19 BCL9 PMC9637639__F6 Identification of the effect and mechanism of Yiyi Fuzi Baijiang powder against colorectal cancer using network pharmacology and experimental validation BAD POLK APC MSH6 MYC CASP9 PMC3734838__F6 Schematic illustration delineating the role of the AKT/Foxo3a/Bim pathway in selenite-induced apoptosis of CRC cells SRC PTEN PMC7792222__F2 miRNA-mediated regulation of BCSCs via targeting the Wnt/Beta-catenin signaling pathway APC AXIN1 LRP5 CCND1 LRP6 DKK1 TCF4 PMC10878789__F10 Schematic diagram illustrating the occurrence of asthma NLRP3 ULK1 ATG9A PMC7453253__F1 Imbalance of T cells in asthma pathogenesis STAT4 IL33 IL25 TSLP GATA3 BCL6 FOXP3 PMC7528619__F1 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 TBK1 GGH TLR4 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS MAL PMC5176079__F1 Stress kinases in the modulation of metabolism and energy balance EEF2K ATF2 JUND IRS1 PMC10669090__F2 The influence of risk factors on the formation of peak bone mass IGF1 RUNX2 SOST CP PMC7247003__F2 Schematic presentation of key pathways activated in a colorectal cancer cell by three groups of cell membrane receptors EGF GALR2 EGFR GRB2 GAL BDNF GALR1 FADD PMC7499294__F1 ER stress-induced apoptosis in lesional macrophages and ECs ATF4 EIF2A TRAF2 PMC7499294__F2 ER stress-induced inflammation in macrophages and ECs NLRP3 ATF4 EIF2A TXNIP TRAF2 PMC7793297__F13 Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells TLR4 RUNX3 RUNX1 SAG CD40 TNF ELL PMC7209958__F1 Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? UROD UROS HMBS CPOX POR PMC3413046__F2 Integrated functional association analysis of protein and genetic interactions on alanine and aspartate SHMT1 GPT ALAS2 AADAT ESRRA HDC MOCOS HEL-S-26 KYNU GOT2 PC DDC GPT2 AGXT PDXDC1 ZNHIT3 GAD1 HEL60 HNF4A ABAT PSAT1 COQ9 SGPL1 SPTLC2 SPTLC3 GLDC HEL-S-51e pcap AGXT2 GLUD1 PMC7792222__F5 miRNA-mediated regulation of the BCSCs via targeting the BMI-1 signaling pathway MDM2 RING1 CDK4 BMI1 PMC7792222__F4 miRNA-mediated regulation of BCSCs via targeting the PI3K/AKT/mTOR signaling pathway PTEN MTOR PMC5001910__F3 A guide to immunometabolism for immunologists NLRP3 IL1B IFNG HEL-S-162eP PMC7263313__F4 Targeting senescent cells to attenuate cardiovascular disease progression CGAS DNASE2 TREX1 PMC6727512__F3 Biosynthesis of AhR ligands from tryptophan metabolism HEL-S-90n CYP2E1 PMC6727512__F1 AhR transcription in mammalian cells and the putative mechanism of AhR activation CUL4B AHRR AHR CYP1B1 POLL CYP1A2 POLI PMC3660516__F4 Statins Are Associated with Reduced Risk of Esophageal Cancer, Particularly in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis PI3 RHO RAC1 PMC4475795__F1 UPR signaling schematic SP2 ATF4 EIF2A SP1 PMC9032796__F3 Epitranscriptomics of SARS-CoV-2 Infection METTL3 STAT2 IRF3 JUN MGA PMC8231835__F1 MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis HMGA2 FOXP4 SOX2 CTBP1 TIMP3 SRC PTEN STAT3 PMC9551057__F8 Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NFKB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus IL10 APC MYD88 STAT3 PMC3043796__F3 Proteins of signaling pathways activated by ET-1 are targets for O-GlcNAc HEL-S-11 SRC ARHA RHO PMC3043796__F1 Signaling pathways activated by endothelin-1 (ET-1) in vascular smooth muscle cells (VSMC) HEL-S-11 SRC ARHA RHO PMC11653592__F1 Main metabolic processes of estrogen CYP1B1 CYP3A4 HSD17B1 CYP1A1 HSD17B2 PMC3072047__F1 Carbon flux rerouting during Mycobacterium tuberculosis growth arrest TGS1 HEL107 DLAT PMC11653592__F2 Mechanism of 16Alpha-OHE promoting pulmonary hypertension SMAD2 SMAD4 NOX4 TNF SOX17 ID1 CCND2 BMPR2 HEL-S-44 CCND1 COIL PFKP SMAD1 DKFZp781O1323 APOE CD36 PMC4854877__F2 Dynamic angiogenic signaling balance and angiogenic switch PLCG1 FYN PKD1 LPA CD36 PMC11653592__F4 4-OHE in pulmonary hypertension; 4-OHEs competitively decrease the activity of 2-OHE2, inhibiting the formation of 2-ME2 COX2 KEAP1 TNF MTOR HEL-S-22 PMC9078765__F5 Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension TH APP DAP PMC11653592__F5 Influence factors of CYPs and HSD17B in PH COX2 PDE4B IGF1 AHR CYP1B1 IGF2 CCND1 HSD17B1 HSD17B2 TNF PMC3875720__F4 Upregulated Genes Encode Key Enzymes in Central Carbon Metabolism.Steps in the glyoxylate cycle (A), gluconeogenesis (B), and oxidative pentose phosphate pathway (C) are shown MAS1 PCK1 FBP1 tal-1 PMC3295664__F1 Methanol utilization (MUT) pathway in P AOX1 HEL-S-49 FBP1 PMC4112277__F1 The PPP and glycolysis is shown HEL107 HEL-S-133P PMC9610969__F2 Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer CCND1 BAX PMC3824052__F2 Smoking-Induced CXCL14 Expression in the Human Airway Epithelium Links Chronic Obstructive Pulmonary Disease to Lung Cancer MUC13 JUP CXCL14 ST14 PMC8779729__F1 Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential HEL-S-102 GPX4 LPCAT3 FACL4 KEAP1 ALOX15 IREB2 DKFZp686F0183 PMC7813639__F2 Prospects for pharmacological targeting of pseudokinases EPOR FAM20C PI3 FAM20A EPO BRAF FRK TRIB1 GHR TRIB2 RFWD2 PMC7140895__F5 Expression of genes in biosynthesis pathway of catechins, theanine, and caffeine under N, P, and K starvation F3 AIDA PMC9482317__F2 TGFB signaling in the tumor metabolic microenvironment and targeted therapies SMAD2 SMAD4 MTOR SKP2 PMC12236007__F7 Hypothesis schematic models illustrates that Myh3 regulates the development of porcine intramuscular preadipocytes through the p38 MAPK signaling pathway to affect IMF content HAL CDK2 LPL PIGS CEBPA PMC9482317__F3 TGFB signaling in the tumor metabolic microenvironment and targeted therapies SLC7A5 SMAD2 SREBF2 TGFBR3 HEL107 TGFB1 FASN CD36 PMC3275361__F3 Signaling and cross talk of the PTH and Wnt signaling pathways in osteocytes WNT3A LRP5 LRP6 PTH DKK1 AXIN2 PMC8977630__F3 Novel Synthetic and Natural Therapies for Traumatic Brain Injury HMGB1 IGF1 APC MYD88 AQP4 BDNF PMC6241212__F2 Innate antiviral immune responses during viral infection TANK TLR9 STAT2 IRF9 TRAF3 TRAF6 TLR3 MX1 USP18 IFNG STAT1 ISG15 TLR8 TLR7 TYK2 CSA2 MAVS PMC2646278__F5 Pathways of global genome nuclear excision repair (GG-NER) and transcription-coupled nuclear excision repair (TC-NER) CETN2 CCNH XPC XPA RBX1 CDK7 PMC4482723__F1 Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease HEL-S-90n GIG8 KMO IDO2 ID1 TDO2 PMC9699386__F5 High Glucose-Induced Cardiomyocyte Damage Involves Interplay between Endothelin ET-1/ETA/ETB Receptor and mTOR Pathway FOS MTOR BAX PMC8131923__F3 Adipose tissue plasticity and the pleiotropic roles of BMP signaling BMP2 ATF2 BMP7 BMP4 PMC8131923__F4 Adipose tissue plasticity and the pleiotropic roles of BMP signaling BMPR2 SMAD1 DKFZp781O1323 PMC3163143__F2 Schematic presentation of molecular changes associated with N-Myc amplification in neuroblastoma MAX MYCL MDM2 MXI1 PMC8710790__F2 Cholesterol‐Associated Steatohepatitis in the Development of NASH NPC1 ABCG8 ABCG5 NPC1L1 ABCA1 ACAT2 PMC3163143__F3 Genomic and non-genomic actions of all-trans retinoic acid (ATRA) RAE1 APP ADAM10 SKP2 PMC8131923__F5 Adipose tissue plasticity and the pleiotropic roles of BMP signaling ATF2 BMP4 PMC7365923__F1 Artemisinin-family drugs for cytokine storm in COVID-19 CCL24 STAT4 TRAF3 TRAF6 IL6 TIRAP IFNG PMC3271661__F3 Summary of Kit/Kitl signaling during spermatogenesis KIT SOX3 BCL6B DAZL DND1 FSHR BMP4 PMC9270134__F6 Investigation of Molecular Mechanism of Banxia Xiexin Decoction in Colon Cancer via Network Pharmacology and In Vivo Studies CCR5 MAPK8 MAPK3 GSK3B HEL-S-99n MAPK14 CXCL8 CCL2 HIF1A HMOX1 PRKCA MMP2 CASP9 SRC MAPK1 B2M NOS2 CASP8 FOS VEGFA TNF HLA-B RXRA EDN1 EDNRB CXCR4 BCL2 TGFB1 HLA-G CCR3 EGFR INS PTEN MTOR COL1A1 TLR4 RPS27A CCND1 CDC2 IL1B JUN BAX IL10 MMP9 PTGS2 NFE2L2 CYP2E1 RS1 CASP3 NFKBIA RELA PIK3CA CYCS PMC3492913__F1 Diagrammatic representation of BMP signaling pathway BMPR2 BMPR1A SMAD1 DKFZp781O1323 PMC6270990__F2 PD-1 action on T-cells APC CD80 PMC338271__F1 HDL enhances NO production by eNOS in vascular endothelium APOB SRC PMC8484365__F2 Endocrine Disruption and Reproductive Disorders: Impacts on Sexually Dimorphic Neuroendocrine Pathways EGF ERG EGFR TF PMC3562404__F2 Biochemical relationships between the CDP-choline pathway of PtdCho synthesis, the degradation of PtdCho, and general phospholipid metabolism in mammals CHDH SMS PMC5964648__F3 UPRmt and stem cell regulation ATF4 PHB2 SIRT1 PMC7387468__F3 piRNAs related to the epigenetic control of pathways involved in vesicles transport, phagocytosis, demyelination, apoptosis, inflammation, loss of sensation, and pain are differentially expressed in leprosy patient (LP) IL21R ETV6 TRPV1 CACNA1C CARF SLC1A2 GLI4 SV2C CLVS2 KCNH1 ENTPD5 KCNK13 CASP8 KNOP1 SHISA6 SLC9A2 TMEM59 GGCX IL23R CASP3 GNA11 KCNQ2 GNAI3 TYRO3 DUSP8 PMC3319314__F3 APE1 role in DNA base excision repair (BER) FEN1 PCNA PMC6213852__F1 Host metabolism and cytokine induction TBK1 MFN2 CGAS IRF3 MYD88 HIF1A MTOR MAVS PMC8126031__F3 Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients IGF1R ZEB2 MTOR IRS1 STAT3 PMC11956735__F2 Platelet factor 4 (PF4) regulates several immune cells TLR9 IL13 PF4 TGFBR1 APC CCL5 IL6 CXCR3 TLR8 PDC TLR7 IL2 SYK PMC7265888__F2 Annotated KEGG pathway of Endocytosis (A), Peroxisome (B) and MAPK signaling pathways (C) about differentially expressed genes MPV17 PEX7 DAO AMACR PTS EPHX2 AMPH CROT NUDT7 MVK PMVK MAX BIK PAOX GRB2 KEL PXMP2 EGF EGFR GIP VPS36 BAAT LDLR XDH DHRS4 ddo JUN CD14 LOC51064 CHL1 NUDT19 PIPOX EHD2 PXMP4 HMGCL PEX16 PEX3 NLK PEX19 PEX6 DBP PEX2 PEX10 PEX12 PECR PEX26 MLYCD PHYH TRAF2 PMC5986633__F7 Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death TSC2 KLF15 BCAT2 MTOR RHEB PMC6406952__F2 LncRNAs are mediators of angiogenesis and inflammation in EC VEGFA TUG1 STAT3 PMC7753952__F1 LKB1 in glucose metabolic reprogramming TSC2 TSC1 SIK2 HDAC10 F2 ENO1 MTOR CRTC3 HEL-S-133P RHEB HEL-S-162eP PMC9008213__F2 Two-Faced Role of Autophagy in Endometrial Cancer ULK4 MTOR PMC6389615__F1 Schematic representation of genes involved in osteoclast-poor and osteoclast-rich osteopetrosis RELA SNX10 PMC5597599__F13 Computational modeling framework EGF SOCS3 MAPK14 PMC11638062__F2 Examples of protein ubiquitination and their roles in ovarian cancer RNASET2 FBXO16 FBXO2 HIF1A SOX6 FBXO6 TRPM7 PMC11638062__F3 Examples of protein phosphorylation and their roles in ovarian cancer IRS4 SIK2 EGFR MYL2 PDK2 PTEN MTOR FER CDK2 HEL164 FOXK2 TRIM37 MYLK PIK3R2 PMC8495205__F1 Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents NCOR1 FOXA1 CYP11A1 CYP17A1 NCOR2 PMC3690158__F1 Wnt signaling pathways SRC RYK PMC6316648__F3 Major mechanisms for hepcidin regulation ERFE BMP6 HAMP BMP2 SMAD4 TMPRSS6 HFE JAK1 SMAD1 TF TFR2 STAT3 PMC11823593__F2 Canonical and non‐canonical Wnt signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 RYK ARHA DKK1 RHO GPR49 LGR6 DAAM1 RSPO1 JUN PMC12086632__F2 The H2S–NO–HNO–TRPA1–CGRP pathway as a crucial element in migraine pathogenesis TRPA1 PMC11357267__F3 Pathways altered in chickens vaccinated with GII SEL1L CANX OS9 AMFR EBP ATF4 EIF2A HEL-S-99n BCL2 VCP TRAF2 XBP1 PMC7687681__F7 Indirect regulatory functions of miR-128-3p on FOXO4 FOXO4 NPTX1 SIRT1 PMC5983678__F1 GPCRs signaling pathway in HCC HEL-S-11 RHO LPA PMC10889780__F9 Putative roles of glutathione and AP-1 in the cooperation between VDDs and Nrf2 activators in inducing differentiation of AML cells MAF NR1i1 KEAP1 RXRA PMC6036887__F2 Butyrate suppresses colorectal cancer development NRP1 SP1 BAX PMC3763548__F8 Role of the eIF2A/ATF4 signaling pathway in the transcriptional activation of autophagy genes GABARAPL2 ATG12 ATG3 ATF4 EIF2A ATG10 DKFZp762B153 DKFZp686F0183 NBR1 GABARAP PMC9606825__F2 NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia BCR NOTCH1 ADAM17 PMC4055861__F2 Base excision repair (BER) pathway FEN1 NEIL2 MBD4 TDG NEIL3 LIG1 UNG OGG1 MPG NEIL1 PMC11931723__F7 Genomic potential for tryptophan and indole-3-acetic acid (IAA) synthesis in Anza-Borrego isolates of Bradyrhizobium and Methylocaldum DDC DEDD PMC8530968__F2 Axon growth and innervation of peripheral targets HGF NGF TP53INP2 CD40 ROR2 RAC1 BDNF ROR1 PMC8261594__F5 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology KL MAX HEL-S-11 REL PMC12022909__F1 AhR-based drug discovery AHR F3 PMC8261594__F6 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology CASP3 TNF PMC12022909__F2 Rewired Yonemitsu MCR: scope and mechanistic insights ATM PMC5338934__F1 Transport pathway of irinotecan.Notes: A prodrug, irinotecan, is moved into hepatic cells by passive effusion CES2 CES1 APC ABCC2 ABCB1 UGT1A1 PMC7886690__F1 Signaling pathways activated in the unfolded protein response (UPR) ELF2 ATF4 TRAF2 PMC7430846__F6 Signaling pathways associated with cold acclimation of two carp species activated in the FoxO signaling pathway IGF1R EGFR PDK2 INS PTEN CCNG2 HMGCR INSR IGF1 GRB2 BNIP3 SIRT1 CD36 PMC7353687__F4 Signal pathways and metabolic pathways involved in abnormal RBP HOXD10 MYC CD44 PTEN STARD13 HOXD1 STAT3 PMC9515729__F2 Beneficial Role of Vitamin D on Endothelial Progenitor Cells (EPCs) in Cardiovascular Diseases NR1i1 VCAM1 IL6 PMC4038461__F6 Finding Novel Molecular Connections between Developmental Processes and Disease SRC HIF1A MTOR PMC3340185__F5 A model for the XIAP-regulated RhoGDI SUMOylation signaling pathway in modulation of cell motility UBC ARHA OTP PMC8272721__F6 Proposed model of selective anticancer activity of NSLC01 in cancer cells with high NRF2 activation EEF2K PSAT1 ASNS EEF2 PSPH PHGDH PMC7472841__F3 RIG-I-like receptors (RLRs) antiviral signaling pathway TBK1 IRF7 TRAF3 TRAF6 IRF3 TRAF2 MAVS PMC8955204__F1 MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging MFN2 IGF1 TRIM63 MTOR RPTOR PSMD3 PMC3203691__F3 CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications CXCL9 IFNG PMC138693__F2 Phosphoinositide 3-kinase (PI3K) signalling and cancer ATM PTEN BRCA1 PMC4502956__F1 TRAIL signaling pathway CASP3 CASP6 APAF1 CASP9 BCL2 MCL1 CASP8 FADD BAX PMC3095770__F2 Hypothalamic proopiomelanocortin processing and the regulation of energy balance POMC NHLH2 PCSK2 STAT3 PMC4502956__F2 TRAIL signaling pathway and some points of therapeutic intervention BCL2 MCL1 PMC11918095__F7 SiO influences fibrosis in HTMCs via ferroptosis induction GPX4 SLC7A11 NOX4 PMC9283766__F2 Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson’s Disease Pathogenesis and Treatment TH JUN PMC11907553__F1 The KRAS signaling pathway TBK1 BAD MTOR CDC42 PMC10418793__F6 Major pathways involved in retinal inflammation FOS RELB MTOR JUN STAT3 PMC3270265__F5 Regulation of cell death by glucose metabolism BAD MTOR FADD PMC11212664__F8 Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis NOD1 MYD88 NOD2 PMC3270265__F3 Glucose metabolism in cancer cells TIGAR F2 ENO1 HEL-S-162eP PMC9102069__F2 Immunogenic Cell Death, DAMPs and Prothymosin A as a Putative Anticancer Immune Response Biomarker MLKL BAX PMC8402745__F4 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges STAT1 SOCS3 ARID5A SOCS1 STAT3 PMC6400555__F3 Models for the roles of Scribble in organizing molecular interactomes involved in synaptogenesis, epithelial polarity, and adhesion, and growth regulation SCRIB LATS1 RHO LATS2 FAT1 DLG5 PMC11974557__F1 Adipose Tissue Inflammation and Insulin Resistance Mediated by TLR4 Activation and Adipokines CRP IRS1 PMC8402745__F2 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges DPP4 ACE2 TMPRSS2 PMC8402745__F3 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges NLRP3 HMGB1 TLR4 MASP2 MYD88 PMC10216084__F8 TRPV4 and TRPM8 signalling pathways relevant to the present study TRPV4 TRPC6 C6 TRPC3 TRPM8 PMC2391280__F1 A signaling pathway AKTing up in schizophrenia DRD1 DRD2 PMC3216694__F1 Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors PC HEL-S-11 RHO LPA LPP PMC7212589__F8 Mechanistic working model of EVI5 in controlling Emi1 accumulation or TGF- B/Smad signaling pathway: MiR-486-5p regulates EVI5 expression via Emi1 or TGFB/Smad signaling in NSCLC CCNA2 MMP2 APC CDH2 PMC7997242__F4 CD226 downregulation SRC CD226 PMC4923112__F3 Classification pathway for primary lymphedema GJC2 VEGFC FH FLT4 MTOR FOXC2 CCBE1 KIF11 GATA2 PMC1952166__F1 Signaling cascades required for TCR-mediated integrin activation PLCG1 ITK LAT CDC42 PMC6059364__F2 Crosstalk of Notch with p53 and p63 in cancer growth control GADD45B BAD SCO2 MDM2 KLF4 PTEN BCL6 PMC4856261__F6 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes EGF NGF TRADD PLCG2 MYD88 MAP3K7IP1 HDAC1 UBE2V1 CARD11 LCK ZAP70 HDAC2 CD40 TNFAIP3 FADD TIRAP TAB3 PMC4856261__F4 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes STAT2 IFITM3 IFITM2 IFITM1 IFNG STAT1 OAS1 BCL2 TYK2 JAK1 IRF-1 PSMB8 SOCS1 BAX PMC3084988__F2 TLR structure and signaling IRF3 TLR3 TIRAP PMC4856261__F5 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes RIPK1 TRAF3 TRAF6 TRIM25 TRAF2 FADD PMC9619213__F2 Follistatin-like protein 3 in human non-tumor pathophysiologies and cancers MMP2 YAP1 SMAD2 ADAM12 MMP9 IL1B SIRT1 CD36 FSTL3 PMC7955704__F2 EGFRex20ins TKI resistance ERBB4 EGFR CDK6 PMC7608616__F3 Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance GSK3B PTEN BAX PMC11203611__F4 Diagram of endocannabinoid biosynthesis and mode of action of the endocannabinoid system within a neuron NAPEPLD FAAH TRPV1 PMC5599995__F6 Proposed model by which mesenchymal stromal cell (MSC) derived soluble PD‐1 ligands modulate the activation status and effector function of CD4+ T cells PTEN PMC5027689__F1 Fanconi anemia (FA) DNA damage repair pathway FANCD2 BLM POLK SLX4 EME1 UBE2T POLN CLK2 PMS2 BRCA2 FAAP24 ATRIP FANCM EME2 FANCL FANCA ATR FANCB FANCE FANCG FANCF POLI PMC6747410__F1 Signaling pathway of DNAM-1 receptor FYN VAV1 PLCG2 PMC3023986__F2 Wnt Signaling as a Therapeutic Target for Bone Diseases LEF1 APC TEF LRP5 SRC LRP6 SFRP1 RYK ROR2 DKK1 PMC9377071__F7 Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease RIPK1 RIPK3 MLKL PMC3422444__F1 AIDing antibody diversity by error-prone mismatch repair MSH6 MSH2 PCNA PMC3422444__F2 AIDing antibody diversity by error-prone mismatch repair RNF8 MSH6 MSH2 H2AX PMS2 PMC3923659__F3 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer IL10 MAPKAPK2 IRF7 IRAK1 MBP IRAK2 TRAF6 IL1R1 IRAK4 MYD88 MAP3K7IP1 IL1B TAB3 PMC5076853__F1 More to life than NFKB in TNFR1 signaling RIPK1 TRADD SHARPIN TNF TRAF2 TAB3 PMC5749242__F5 The two fates of C3b generated in the retina HEL-S-62p CFB CFD CFH CFI PMC11056704__F8 Graphic illustration for role of oestrogen‐induced exosomal SNHG17‐CCL13‐CCR2‐M2 macrophage axis in ovarian cancer CCR2 CCL13 PMC3923659__F2 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer MAPKAPK2 IL1A IRF7 IRAK1 MBP IRAK2 TRAF6 IL1R1 IRAK4 IL6 MYD88 MAP3K7IP1 IFNG COX2 CCND1 IL1B TAB3 PMC6617682__F1 The mechanism of exosomal miRNAs loading AGO2 DGCR8 DROSHA PMC4937511__F9 Candidate SCI biomarker input for Systems Biology and pathway network analysis HEL-S-49 ANXA1 GOT2 ANXA2 EEF2 FASN PMC3405917__F4 EMT in fibrosis ZEB2 CDH2 PMC9412305__F4 The Innate Immune Response during the Human Papillomavirus Life Cycle BAX PMC9412305__F5 The Innate Immune Response during the Human Papillomavirus Life Cycle TBK1 CGAS IRF3 MAVS BAX PMC7085234__F1 RREB1-involved in MAPK signaling pathway RREB1 EGFR GRB2 PMC7085234__F2 RREB1 regulates different target genes in different cancers ANKRD1 RREB1 ANGPTL4 ARHGEF2 PMC3722486__F9 Proposed role of Foxg1 in CM development LEF1 MSX1 CCND1 FOXG1 OTX1 WNT2B FOXD1 PMC4524513__F1 Tendon Mechanobiology: Current Knowledge and Future Research Opportunities AIP DES COMP OTP PMC3405917__F1 Wound repair and fibrosis IL33 IL25 TNF TSLP TGFB1 PMC6841741__F3 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Inflammatory disease pathway NCL MAP2K4 PSPN TNF LMNA MAF HPS4 GPR75 EDDM3B GPR180 GPR135 CSF2 JUN PMC5725281__F9 Cardioprotective effect of CAPE-oNO2 NRF1 SMAD2 HEL-S-44 SIRT1 BAX PMC7052362__F2 Tumor-associated macrophages (TAMs) in promoting tumor progression and related mechanisms SIRPA CD47 SIGLEC10 LILRB1 APOE STAT3 ELMO1 CD24 PMC6384614__F5 Biosynthetic pathway for the capuramycin-type nucleoside antibiotics APP LIPK HEL-S-66 PMC6841741__F2 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Organismal Injury and Abnormalities, Reproductive System Disease pathway GPR75 SELENOW PGC SHE CRACR2B SLC22A10 MT1A DNAH7 SP5 KANK3 PMC9553103__F2 ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain ENPP1 ADA AK1 PNP PMC9055718__F6 Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells LTA IRF3 IL1B PMC5931372__F1 Clonal evolution mechanisms in NT5C2 mutant relapsed acute lymphoblastic leukemia TPMT PMC8632384__F11 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder UMPS TNF JUN SELE PMC7576987__F5 Working model of 2,3-DCPE in colon cancer cells ATM ATR PMC6006682__F4 Representative coverage of Calvin-Benson cycle enzyme FBP1 HEL-S-68p HEL-S-162eP PMC8324677__F1 Stress kinases in the development of liver steatosis and hepatocellular carcinoma FGF21 NCOR1 FABP5 RAC1 IRS1 EHHADH NR1C1 ACOX1 BAX PMC4237616__F2 Survival tree analysis of significant SNPs associated with NSCLC survival identified from the single SNP analysis (q<0.10) in our initial cohort AXIN2 WNT5B WIF1 CXXC4 PMC8949960__F1 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training RICTOR IGF1R IGF1 ALK SMAD2 IL6 MTOR PMC8949960__F2 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training IGF1R IGF1 ALK SMAD2 IL6 MTOR PMC4965740__F9 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways HHIP MED12 BOC HEL2 GAS1 MED23 DKFZp686L0365 SAP18 SHH SMO SIN3A MED1 SKI DHH CDON IHH PTCH2 KIF7 KIF27 SDC2 CDK8 DYRK1A CREBBP SUFU GLI3 PTCH1 NR2E1 SMAD1 MED6 PMC3080795__F2 Scheme for CCM including main pathways - glycolysis/gluconeogenesis, penthaphosphate pathway, citrate cycle, overflow pathway SUCO RPIA CIT MAL PMC7460634__F2 Semaphorins in adipogenesis SEMA3A GSK3B SEMA3G PMC4965740__F8 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways FHL1 PIK3R1 BLOC1S1 MAGEA1 NUMB HES6 CNTN1 ASCL1 MAML3 GSK3B JAG2 DLL3 NOTCH3 FBXW7 HES1 HES5 DLL4 MAML2 APP NOTCH1 SNW1 HDAC2 SPEN SIN3A SAP30 NOTCH2 RBPJ TCF3 PSEN2 DTX1 WDR12 LEF1 HEY2 EP300 PSEN1 NFKB1 LCK YY1 SMAD1 SKP2 PIK3R2 STAT3 ITCH PMC8380049__F2 Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension BMPR2 BMP10 SMAD4 SMAD1 DKFZp781O1323 PMC6637138__F7 Innate immune response activation in BRCA2-deficient cells STAT1 CGAS STAT2 BRCA2 IRF3 IFNAR2 IFNAR1 PMC4264220__F1 Schematic representation of homocysteine metabolism and intersection with glutathione (GSH) production and folate cycle PMC3309495__F2 Pathway analysis of altered metabolites upon paroxetine treatment GYS2 DPP4 GCK HEL-117 PMC4155643__F1 Pathways of sphingolipid degradation and synthesis HACD3 FACL4 HACD2 HACD4 ALDH3A2 SPHK2 ACSL6 ACSL5 CERS3 ACSL1 ACER3 LASS1 CERS5 CERS2 HACD1 ELOVL6 ASAH2 ELOVL1 ELOVL4 ELOVL5 ELOVL3 ACER1 ELOVL7 SPHK1 ELOVL2 ACSL3 CERS6 PMC7348939__F1 Fundamental aging mechanisms that contribute to sarcopenia MFN1 MFN2 OPA1 PMC7348939__F2 Possible molecular mechanisms of cellular senescence in skeletal muscle cells CYR61 WNT3A CDK2 CDK4 PMC6028526__F2 Insulin biosynthesis and secretion PDX1 SST INS NEUROD1 MAFA PMC3943598__F1 Molecular mechanisms in Carney complex (CNC) and McCune-Albright syndrome (MAS): Receptor activation (ligand binding) makes GsA to exchange GDP to GTP, GsA is then freed from the BetaG dimer and activates adenyl cyclase (AC) GNAS PMC3056800__F7 Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds GDA GC AIDA ASL PMC3639322__F3A Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis MGLL GCK CRAT HEL-S-104 NR1C1 APOM LEP CIDEC ACACB GBP2 HEL-S-273 PPARG ITCH PMC3681733__F2 Reprogramming Neutral Lipid Metabolism in Mouse Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes DGAT1 LIPE PC ABHD5 LIPA LPA MGAT1 PLD3 MGAT2 PMC3257556__F2 Known components of the PCP signalling pathway and related cellular functions FZD3 ROCK1 FUZ PTK7 INTU ARHA CELSR1 RAC1 DVL1 FAT4 FRZB DVL2 VANGL1 RHOB PRICKLE2 CDC42 PMC5813884__F5 Nitrogen regulation of the GAAC pathway ELF2 EIF2A CDC34 PMC5813884__F6 Influence of the RTG pathway on nitrogen metabolism HEL-S-26 MKS1 HEL60 PMC2813229__F4 Pathway analysis result showing 18 differentially expressed proteins following 50% PH can be sorted into the c-myc pathway PML NDUFS3 PROX1 ACADM PMC6151665__F8 Mechanism of emodin to inhibit IAV replication and IAV viral pneumonia TLR4 GCLC TRAF6 NQO1 PMC5088520__F1 Path2enet: generation of human pathway-derived networks in an expression specific context CTBP2 NUMB MAML3 CTBP1 JAG2 LFNG RBPJL DLL3 HES1 HES5 DTX3L DLL4 MAML2 DVL2 SNW1 NCOR2 MAML1 KAT2B PSEN2 DTX1 DTX2 DTX3 DTX4 DVL3 DVL1 CREBBP PSEN1 PSENEN PMC5088520__F2 Pathway-expression-networks produced for B cell CD19+ (top), T cell CD8+ (bottom left) and T cell CD4+ (bottom right) based on the transformation of the NOTCH Signaling Pathway done with Path2enet DTX3L CTBP2 NUMB EP300 LFNG MFNG DVL3 DVL1 CD19 PMC8835043__F1 Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin CDK2 CDK4 CDC2 PMC1371031__F4 Model on Bcr effects on Beta-catenin BCR GSK3B MYC PMC6509867__F8 Annotated functions of the extracted pathway network HEL-S-11 EGFR GNAL GAL TUNAR LAT PMC6948307__F5 Schematic diagram of IL-1B signaling pathway in MSC adhesion to HUVECs IL16 MSC PMC3210925__F5A Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis PGP HPR PMC6635885__F2 Activation modes of the NLRP3 inflammasome and the regulatory mechanism of CVDs NLRP3 IL18 TLR4 CASR TXNIP RYR2 IL1B PMC2683106__F5 Promoting cell proliferation and repressing differentiation SOX2 PITX2 MIXL1 EBF2 MTOR CCNG2 PMC6368065__F7 Hematopoietic deletion of COX-2 increases adiposity and AT inflammation in obesity COX2 MMP12 AXIN1 FZD4 HEL-S-104 DVL3 PMC6220476__F1 Circular RNA ITCH and 0043256 act as miRNA sponges to regulate the expression of ITCH ITCH PMC8269088__F1 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets TLR5 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MTOR TLR1 BTK FYN BCR BASH LYN GRB2 SYK STAT3 MAL PMC8269088__F2 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets DLL4 CCL19 DLL3 FBXW7 PMC7555769__F2 Noncanonical HH signaling pathway ARHA SMO RHO MTOR PMC6117282__F2 Gene networks involved in a) 'developmental disorder, ophthalmic disease, organismal injury and abnormalities' (score = 41) and b) 'cell-to-cell signaling and interaction, nervous system development and function, inflammatory disease' (score = 21) UNKL DDX24 TIGD1 TMED8 GPR119 NBPF10 IFNG SPATA16 MIMS2 PLPP5 CFHR2 SNTB2 CMTM2 APP UNK JUN VPS35 FOS RAC1 VDAC3 IPP FOXO1 CASP3 RYR3 APH1B PMC7555769__F3 SMO in cancer CCNI MMP2 MMP9 BCL2 SMO RHO BMP4 PMC4496218__F9 Pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis VCAM1 PTEN PMC11731776__F2 Figure compares normal and G3BP1-depleted or inhibited senescent cells IRF3 STAT3 PMC7555769__F1 Canonical Hedgehog (HH) signaling pathway CD133 SUFU BCL2 SMO FOXF1 PMC3535180__F1 Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? COX1 CRP IL1B PMC11731776__F3 Figure illustrates the DNA damage response pathway leading to cellular senescence ATM CDK2 CCND1 CDK4 ATR CDK6 GATA4 PMC6058063__F1 Immunoglobulin G4-related disease (IgG4-RD) and immune pathways to therapy. Naïve B cells are activated by exposure to antigens IL10 IL21R CD27 BCR CD40 CD80 IL-21 CD19 PMC8882273__F7 Selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease NLRP3 HTT IL1B PMC5542228__F5 Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance PRKAA2 RPS6KA4 CAB39 MTOR EIF4EBP1 PDPK1 RPTOR MLST8 RPS6KB1 RICTOR RPS6KA1 RPS6KB2 PIK3CA RPS6 EIF4B PMC9324353__F2 Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 EGFR BCL2 CDK4 HEL-S-100n MTOR FADD BAX PMC12146343__F2 Signals from the gut microbiota lead to the differentiation of T cells into various subtypes TLR4 MYD88 MTOR TGFA GATA3 FOXP3 PMC12146343__F1 Gut microbiota involved in the development of AIH TLR4 AHR MTOR PMC6605322__F7 Scheme summarizing the protective effects of sevoflurane on lipopolysaccharide-induced inflammation and apoptosis by suppressing the activation of the miR-27a/TLR4/MyD88/NFKB signaling pathway TLR4 MYD88 PMC8579454__F3 Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development FYN TLR4 LYN IL8RB IRAK4 MYD88 TNF ZDHHC6 FASN CD36 PMC4127586__F2 A model of Src homology 2B1 regulation of leptin signaling SH2B1 IRS1 STAT3 PMC6692341__F5 Control of fruit biochemical composition CD2 CER1 ACER3 CCS HEL-S-5 PMC4699913__F4 Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling PML KIF23 FANCD2 NONO WRNIP1 MAPK14 XPC CHD4 MTOR SPR CHEK2 SMC1A TIMELESS RNF20 ATM INTS3 RAX PIAS1 NCOA1 CDC2 ATR PCNA BAX PMC6192992__F6 Scheme depicting role of HORMAD1 in DSB signaling and repair RNF8 ATM BRCA1 PMC9711961__F8 Paeoniflorin Inhibits LPS-Induced Activation of Splenic CD4+ T Lymphocytes and Relieves Pathological Symptoms in MRL/lpr Mice by Suppressing IRAK1 Signaling TLR4 IRAK1 TNF PMC6764628__F5 Relationships of the top differentially expressed genes within the top GSEA gene sets GEM PTGS2 RRAD ATF3 IL6 HMOX1 HEL-S-102 GADD45B EGR2 MCL1 BTG2 TM4SF1 ADM PMC9693644__F1 Epha2 Receptor Blockers Involved in Cerebral Malaria from Taraxacum officinale, Tinospora cordifolia, Rosmarinus officinalis and Ocimum basilicum: A Computational Approach LTA UNK CCL2 TNF EPHA2 PMC5426657__F7 Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress GCLC HMOX1 NQO1 PMC11392660__F3 Immunologic mechanisms following decellularized matrix transplantation involve several crucial steps TLR9 PTEN MYD88 MTOR PMC2989646__F4 The involvement of zinc metalloproteinases in AB metabolism ADAM8 ADAM9 ADAM15 ADAM33 APP ADAM10 ADAM19 ECE1 ADAM17 PMC8367322__F1 LncRNA BANCR in Human Cancers: An Updated Review APC GSK3B CCND1 PMC6186432__F2 Apoptotic membrane blebbing through DR5/Casp-3/ROCK1 signaling pathway LIMK2 FADD MYLK PMC7642512__F2 CD40 induces activation of autophagy signaling pathway ULK1 ATG16L1 ATG12 ATG3 UNK CD40 MTOR DKFZp686F0183 PMC8367322__F4 LncRNA BANCR in Human Cancers: An Updated Review GRB2 ARHA CDH2 SOS1 TNF PMC8349595__F4 Nutrition, One-Carbon Metabolism and Arsenic Methylation HEL-S-61p AS3MT MTR PC HEL-S-20 GAA PEMT SLC19A1 PMC11817496__F9 The apoptosis signaling pathway triggered by PM2 CASP3 AIP TRADD CASP9 CASP10 PAH TRAF2 CASP8 FADD BAX PMC3096731__F1 Eph receptor and mTOR pathway crosstalk: implications for cancer TSC2 TSC1 PTEN MTOR RHEB PMC4240271__F1 Post-translational regulation of TGFB receptor and Smad signaling ROCK2 BAMBI PPIE USP15 CD44 SMAD4 TRAF6 WWP1 SMURF1 SMURF2 HGS STRAP SKI ITCH PMC6075432__F14 Sodium fluoride induces autophagy in mammalian mice spleen ATG16L1 ATG12 MTOR DKFZp686F0183 PMC9404585__F1 Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2 SRC SYK MTOR TYROBP PMC6803322__F8 Diagram illustrating the IL-6 signaling pathway triggered by the binding of IL-6 and its receptor complex resulting in JAK2/STAT3 activation SOCS3 STAT3 PMC7010923__F2 Proposed model for signaling pathway of fibrosis in MDC1A HEL-S-28 MTOR ACE2 PMC9469193__F8 Antigastric Cancer Effect of Triptolide is Associated With H19/NFKB/FLIP Axis TRADD TNF PMC7822116__F3 Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects? GPX1 PON1 HEL-S-44 SIRT3 PMC5945496__F6 Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells ABCC3 GCLM BRAF KEAP1 SFN SLC7A11 HRAS HMOX1 TXN PMC12136072__F2 Signaling pathway of BMP4 as well as activators and inhibitors of BMP4 cellular signaling BAMBI BMP1 SMURF2 SMAD6 SMAD4 SMURF1 PMC12136072__F3 Recent Advances in the Delivery of Bone Morphogenetic Proteins for Targeting Glioma: An Updated Review NOTCH2 NOTCH4 BMI1 NOTCH3 PTCH1 GLI3 NOTCH1 SHH SMO TNFAIP3 SMAD1 DKFZp781O1323 STAT3 PMC8536203__F9 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping IKBKG CHUK PPP3CA GSK3B PLCG2 IFITM1 CD81 DAPP1 BTK PIK3AP1 BASH LILRB2 GC PTPN6 FCGR2B CD19 FOS VAV1 HRAS CD79B CD79A IKBKB CARD11 NFKBIB MAP2K1 CD72 PRKCB HP RASGRP3 CD22 LYN GRB2 SYK RAF1 SOS1 PMC5468628__F1 GRN and SBN circuits SOX2 WNT1 PROX1 SIX6 VIP BMP4 LMO4 SOX3 GBX2 WNT8B AVP FOXG1 SHH FEZ1 SIX3 HESX1 OTX2 EN1 PMC3649098__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis COX2 IL16 VCAM1 CRP TF PMC8520942__F1 Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations GPX4 WEE1 CDK2 CDC2 MVP PMC5710670__F1 Clinically relevant inhibitors of the isoprenoid biosynthetic pathway (IBP) (a) Statins inhibit HMG CoA reductase, consequently reducing the entire IBP RAP1A FDPS ARHA RAC1 IPP CDC42 PMC5987911__F1 Logical regulatory network graphs for a mammalian cell cycle network (PN1) and a melanoma-related pathway network (PN2), modified from and 1 in Qian and Dougherty, respectively S100P CDC20 HADHB STC2 PMC9319949__F11 Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy NLRP3 HMGB1 TLR4 SQSTM1 DPP4 BCL2 MTOR BAX PMC5854428__F1 Viral manipulation of STAT3: Evade, exploit, and injure PTPRT IL21R SOCS3 EGFR MTOR OSMR PTPRC CNTFR GHR IL7R SRC TYK2 JAK3 TRIM28 JAK1 DUSP2 STAT3 PMC5854428__F2 Viral manipulation of STAT3: Evade, exploit, and injure SOCS3 PC TRIM28 JAK1 STAT3 PMC2957472__F3 Helicobacter pylori: gastric cancer and beyond APC GSK3B LRP5 LRP6 PMC12110123__F9 Ginsenoside CK can enhance the expression of CD69, CD80, and CD86, stimulate the NFKB and AP-1 inflammatory signaling pathway, and induce macrophages to secrete iNOS and TNFA to enhance inflammatory response CD82 CD80 CD69 PMC4715579__F6 Top biological network generated by Ingenuity Pathway Analysis for differentially expressed proteins of (A) ALDH+/CD44+CD24−, (B) ALDH+/CD49f-EpCAM+ and (C) CD44+CD24−/CD49f-EpCAM+ RPLP0 RUVBL2 NAMPT ANXA11 TUBB LONP1 PROX1 HSPD1 WTAP FUS YBX3 CCT4 GLO1 STAU1 PLAA COPS5 NF2 SNRPB CSNK1A1 PDCD11 ATXN10 NUMA1 TARDBP PMC6042724__F3 Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1 NF1 TRPC4 SFN TGFBR1 ENG RGS2 MTDH HRAS PMC12110123__F5 Anticancer Mechanisms of Ginsenoside Compound K: A Review MMP2 CXCR4 MMP9 PMC4397421__F1 Translocations affecting the NFKB activation pathway BIRC2 CARD11 PTS BCL10 TRAF6 MYD88 CSA2 PMC12110123__F4 Ginsenoside CK inhibits the expression of AKT/mTOR/p70S6K1 proteins and blocks the PI3K/AKT/mTOR signaling pathway in cancer cells, reducing the expression of MMP2 and MMP9 proteases MMP2 MMP9 MTOR PMC6476865__F2 The PI3K-Akt-mTOR signaling by bioactive sphingolipids S1PR2 S1PR1 S1PR3 CERK RHEB PMC3011892__F4 Cell cycle pathway containing Treponema denticola differentially regulated genes in calvarial bone compared with sham-infected controls at P ≤ 0.05, adapted from Pathway Express and using the Kyoto Encyclopedia of Genes and Genomes nomenclature CDK2 CDK7 PCNA MYT1 PMC5182153__F1 Insulin Receptor Signaling Pathway Targeted by Surgery-Responsive microRNAs PDE3B BAD SOCS3 PTEN EIF4E MTOR CRK INSR CBL TSC1 LIPE FYN VAMP2 STX4A GRB2 ACLY GRB10 ELL PMC3011892__F5 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles MALL CDK2 CDK7 PCNA ORC2 PMC9692683__F2 SARS-CoV-2-Induced Amyloidgenesis: Not One, but Three Hypotheses for Cerebral COVID-19 Outcomes NLRP3 GFAP CRP S100B PMC3011892__F1 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles PTPRC CD6 CD2 APC CD22 CD40 CD80 CTLA4 SPN CD226 ICOS PMC5567867__F1 Major steps in the HR pathway in budding yeast RAD52 RAD51 ATR PMC3163259__F1 Wnt/Beta-catenin signalling in the absence and presence of Wnt stimulus NLK DKK3 GSK3B DKK1 DKK2 DKK4 PMC7705761__F4 Identification of key gene networks controlling organic acid and sugar metabolism during watermelon fruit development by integrating metabolic phenotypes and gene expression profiles CS DAP PMC5910271__F2 Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases SIRT1 SIRT3 PMC8657568__F1 Plant Dehydrins: Expression, Regulatory Networks, and Protective Roles in Plants Challenged by Abiotic Stress ICE1 MAPK6 PMC8043250__F1 Top left, in red: NK cells recognize tumor targets that lack MHC, as this prevents the inhibitory response mediated by KIR MICB EGFR VAV1 CDS2 CD96 MICA PLCG2 TIGIT CD226 CRTAM PMC3747619__F2 Key reactions involved in the sphingolipid metabolic pathway UGCG CERK KDSR PMC9655901__F3 Interplay between Autophagy and Herpes Simplex Virus Type 1: ICP34.5, One of the Main Actors TBK1 CGAS KEAP1 C1QBP IRF3 MAVS PCNA PMC6321280__F3 Many molecules regulate apoptosis and Hippo-YAP signaling pathway PML IKBKE EGR1 TFAP2C AJUBA CRB3 ARHA S100A1 RASSF6 FBXW7 ITCH PMC5080657__F2 Genetics of immune-mediated disorders MYADM S100A10 FOS NLRP12 CCL5 RIPK2 PPP1R15A STAT1 TAGAP GBP1 CRIP1 GBP2 GBP4 FGFBP2 UBE2L6 KLF6 OCC1 GZMH PSTPIP2 SH2B3 PMC2763943__F2 Nox proteins in signal transduction MAPKAPK2 PAK1 TRADD PMC4694912__F3 MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model ESCO1 DERPC CS RPA3 CHTF18 ATM RPA1 SMC3 MSH6 INS PCNA PMC7082279__F1 Resistant mechanisms of TKIs in target therapies of NSCLC IGF1R SDC4 EML4 LAT2 ALK TFG ERBB2 IGFBP1 EGFR IGFBP4 NRG1 CD74 PMC6321280__F1 Components of the Hippo-YAP signaling pathway LATS1 LATS2 PMC9158463__F1 Understanding How Physical Exercise Improves Alzheimer’s Disease: Cholinergic and Monoaminergic Systems GSK3B APP ARHA SIRT1 PMC7029504__F7 FOXO signaling pathway enriched in KEGG ATG12 INS SMAD4 PTEN INSR NLK ATM CDK2 MDM2 KLF2 BNIP3 SKP2 STAT3 PMC7484684__F5 DE miRNA/mRNA interaction network constructed and visualized using Cytoscape software ADD1 HIPK2 SLC22A3 N4BP1 PRKCA CPNE2 SFRP1 RBKS CHI3L1 TANC2 LRTM2 SPPL3 RAB22A MIPOL1 MYO1D LRP6 STRN3 KRTAP7-1 SLAMF7 MFAP3L LRFN2 SLC7A6OS SDC3 KIFC2 CFTR ST6GALNAC6 AEBP2 SMAP2 MEGF9 PRKCB COQ2 NR1C2 PMC4050496__F2 Notch: Architect, Landscaper, and Guardian of the Intestine EGF FURIN PMC3835661__F1 Cell Death in Heart Disease TRADD TRAF2 FADD PMC8263688__F8 IL-17 signaling pathway plays a key role in laryngeal squamous cell carcinoma with ethnic specificity CHUK TRADD MAPK8 MAPK3 IL17F GSK3B TRAF3 CXCL8 TRAF6 CXCL3 CCL7 IL17RC CEBPB IFNG MMP3 ELAVL1 IL18 CSF2 CASP8 CCL11 MAPK7 MMP9 MAP3K7 TNF HEL-S-125m NFKBIA MAPK13 ANAPC5 NFKB1 JUND TNFAIP3 TAB3 PMC7458396__F2 Cellular signalling pathways mediated by the constitutive activation of US28 CCND1 RHO JAK1 STAT3 HEL-S-162eP PMC4100111__F3 Bioinformatics analysis by String HEL-S-97n KRT18 CPA2 HEL-S-68p HEL-S-125m CPB1 CTRB1 MYG1 OXTR NPLOC4 DNPEP HEL-S-304 UBXN6 VCP PGAM1 PMC3546894__F1 Cytokine regulation of immune response cell phases through gender specific pathways IL10 IL6 IFNG PMC5152733__F1 Lymph node fibroblastic reticular cells in health and disease MFGE8 CXCL13 NFKB2 VCAM1 CXCR4 CCL21 PDPN CXCR5 CCL19 CLEC1B LTBR MADCAM1 PMC5963715__F3 PI3K/AKT/mTOR signaling pathway TSC2 PTEN MTOR RHEB PMC5352059__F4 Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers CDA DAO SOST LY96 MYD88 NCK1 IFNG RIPK1 LCP2 FYN IL18 BCL10 IL2 CDK4 PTPN6 IL4 CSF2 CD3G ICOS CD3E MAL CD14 IL10 CTSK FOS ARHA CTLA4 IL6 CARD11 PAK1 NFKB1 LCK GRAP2 LBP GRB2 PIK3CA CD40 CD80 LAT TIRAP VAV2 PMC9099959__F4 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology AHR ATM ATR BRCA1 PMC9099959__F5 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology TLR7 AHR TRADD IRF7 IRAK1 HEL-S-71 TRAF6 IRAK4 MYD88 TRAF2 TAB3 PMC9099959__F3 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology AHR TRAF6 CYP1A1 PAH CYP1A2 BRCA1 PMC11732762__F2 CD28 signaling in FOXP3 expression and the effects of belatacept APC RELA CD80 MTOR FOXP3 PMC8839664__F6 Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model EGR1 FOS ACACA KLF5 LPL TXNIP XDH KHK TNF SIRT1 HMGCR FASN PMC7056524__F1 In normal B cells, Mir-15/16 target Bcl2 BAD BCL2 BAX PMC5174080__F1 Innate and adaptive immune responses induced by Avian leukosis virus (ALV) TLR7 IRF3 PMC4905167__F1 Novel targets for ATM-deficient malignancies FANCD2 ATM BRCA2 SSB PARP1 PMC10417163__F2 Signaling pathways play an essential role in organizing the Golgi apparatus and maintaining neuronal polarity during neurogenesis GOLPH3 MAJN ARHA PITPNB DAB1 HEL-S-36 ARF1 PMC2597811__F1 Molecular Genetics of Colorectal Cancer: An Overview APC SMAD4 MSH2 PMS2 PMC6376477__F11 Molecular mechanism of circHMGCS1: regulating miR-503-5p to control IGF signaling by functioning as a ceRNA IGF1R IGF2 GLS PMC3010690__F2 Zinc metalloprotease activity in APP processing APP GLA PMC8987592__F2 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis SMAD2 TGFBR1 SMAD4 PMC8987592__F1 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis SMAD2 SMAD4 PMC7544055__F5 Toll like Receptor signalling by Prevotella histicola activates alternative NFKB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa TLR5 TLR4 RELB PMC2855642__F2 Glycosylation of Alpha-dystroglycan FKRP POMT1 POMT2 PMC5116673__F3 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis MMP11 ANXA3 MEIS1 HEL-S-14 RCAN1 PAX3 SHC3 FGFR2 BMP4 PERP FGF10 SHH TBX5 GREM2 F11R COL18A1 MEOX2 GATA2 HMMR BMPR1A ITGA6 IGFBP2 ITGAV MEOX1 SMAD1 TGFB1 MTUS1 CP PMC2612755__F5 A theoretical pancreatic endocrine tumor cell, smooth muscle cell (pericyte) or endothelial cell demonstrating the sites and mechanism of action of novel agents for the management of metastatic PETs EGFR PTEN FLT3 MTOR PMC8518663__F1 Manipulation of auxin signalling by plant viruses TPR SKP1 PMC8518663__F2 Manipulation of auxin signalling by plant viruses TPR SKP1 PMC3904723__F7 Putative functions of the differentially expressed proteins in metabolic processes of rice grain development at high temperatures HEL-S-11 GIP HEL-S-162eP PMC7448212__F6 Mechanism by which MCL attenuates the inflammatory response of NRK-52E cells NLRP3 IL1B PMC10177107__F1 Different signaling pathways and epigenetic mechanisms that have been deregulated during TNBC progression and growth, contributing to stemness ATM BRCA2 PTEN MTOR ATR BRCA1 PMC9108976__F2 Cellular and Developmental Roles of Cullins, Neddylation, and the COP9 Signalosome in Dictyostelium discoideum CUL5 CSN3 DCUN1D1 UBE2F UBE2M CAND1 NEDD8 RBX1 CUL4A NAE1 CUL4B CUL7 C6 CSN2 HEL-117 CUL9 PMC3958149__F2 Example of Janus kinase (JAK) inhibitors blocking cytokine signalling STAT1 JAK3 JAK1 PMC7905801__F1 IDO- and cell-mediated immunosuppression IDO1 APC CD80 PMC6501234__F9 Proposed molecular mechanism for LPS-induced downregulation of StAR expression and progesterone production in pGL NR5A1 GATA6 STAR GATA4 PMC6071399__F3 Analyzing Toll-like receptor signaling pathway by QIAGEN, KEGG and wikipathway websites and drawing pathway by Pathvisio software TES INS EED PMC7890234__F1 Activation of unfolded protein response ATF4 EIF2A TRAF2 XBP1 BAX PMC6387699__F1 Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications GC TET1 PMC10217562__F5 KEGG diagram of plant hormone signal transduction pathway under salt stress BIN2 EBF2 PMC5371797__F2A Non-Canonical Roles of Dengue Virus Non-Structural Proteins TBK1 CS IRF3 MAVS PMC3617338__F1 Multivalency and conditional regulation at the cell surface MGAT5 MGAT1 MGAT2 PMC2584013__F25 ER stress and ROS in NAFLD/NASH ATF4 TRAF2 BAX PMC3438932__F7 The role of dimeric TIR platform for the inhibition and activation of MyD88 signaling pathway IRAK1 IRAK2 IRAK4 MYD88 PMC10891858__F1 Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease MTOR TG PMC7054754__F2 Core signalling pathways maintaining human pluripotent stem cells (hPSCs) IGF1R NODAL SMAD2 FGF2 MYC LRP5 INS SMAD4 LRP6 PMC10891858__F4 Major signaling pathways by ncRNA in NAFLD/NASH as discussed in the text (Created with BioRender MTOR PMC7054754__F1 An overview of class IA PI3K signalling EEF2K ULK1 EEF2 MYC PTEN EIF4E MTHFD2 TSC2 PI3 TFEB USP14 ATF4 MDM2 PFKFB2 CCND1 BCL2 TXNIP MAF1 UVRAG CAD ACLY HK2 POLI PMC2584013__F23 TNF-induced and ROS-dependent events in target cells: the role of JNK activation in mediating cell death TRADD APAF1 RAC1 TRAF2 FADD PMC4918704__F1 TLR4 (toll-like receptor 4) signaling: MyD88 (myeloid differentiation primary response 88)-dependent and MyD88-independent pathways mediate TLR4 signaling CD14 TICAM2 CXCL8 CXCL2 IRF3 IL6 CCL2 MYD88 TNF TICAM1 TLR4 CCL20 CXCL6 TIRAP PMC4546439__F1 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened SUFU PTCH1 GLI3 SMO PMC4546439__F2 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened SOX2 MMP2 ATM MMP9 BCL2 PMC10478475__F8 Hypothesized mechanism by which Ex-4 reduces tau hyperphosphorylation via Wnt/Beta-catenin/NeuroD1 signalling in T2D models APC NEUROD1 PMC12215756__F10 NCC cellular metabolism is coupled to a developmental program FOXD3 SNAI1 HEL-S-30 WNT1 SNAI2 GLS PMC9433570__F9 Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism KLHL9 NGF EHF PTPRK CLEC3B CXCL3 RAP2C UBE2C TFPI2 CDC20 RRM2 CCNB2 CCNB1 KIF20A CXCL6 ALDH3A1 XB IL1B CHI3L1 PMC5428311__F3 Summary of the major global regulatory responses of S PTS SPI1 TNLG7C PMC4438467__F1 Mitochondrial cholesterol trafficking in regulation of macrophage sterol metabolism CYP27A1 LDLR ABCA1 PMC8187249__F2 Protected complex of biofactors and antioxidants improved growth performance and modulated the immunometabolic phenotype of broiler chickens undergoing early life stress TLR7 IL23R TRAF2 SIRT1 TIRAP STAT3 PMC6491684__F8 Schematic representation that hypothesizes the effects of ethanol (A), THC and/or OEA (B) on neurotrophic signaling pathway via AKT and ERK1/2, and its neurogenic response in the hippocampus CASP3 NTF3 BDNF MKI67 PMC3030733__F1 Interventions in nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 signaling pathway MAF KEAP1 NQO1 PMC3308892__F4 ER stress-associated miR-346 induction XBP1 PMC7530341__F6 Proposed gestational age-dependent changes in placental TRP metabolic pathways SLC7A5 SPR ASMT PTS HEL-S-90n KYAT1 KYNU DDC SLC3A2 SLC22A3 AANAT PMC5460696__F1 Schematic of androgen synthesis illustrating the classic androgen pathway (gray boxes) and the steroids of the 11-oxygenated androgen pathway (black boxes) HSD11B2 CYP17A1 PMC5491785__F7 Schema of the putative mechanisms by which myostatin may influence the function of bone cells NFATC1 SMAD2 DKK1 PMC8278082__F7 Naa10p and IKKA interaction regulates EMT in oral squamous cell carcinoma via TGF‐B1/Smad pathway SMAD4 TGFB1 PMC10039534__F2 Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment CXCL10 GSK3B IL2 B2M NEDD4 IFNG FOXP3 PMC4520755__F1 Canonical Notch signalling pathway and relevant pharmacological inhibitors under development in cancer MAML1 CDKN1A DLL4 JAG2 MYC NRARP DLL3 CCND3 PMC4520755__F2 Canonical HH-signalling pathway and pharmacological inhibitors targeting this pathway that are under ongoing development as anticancer therapies DHH SUFU GLI3 KIF3A MYC CCND1 SMO BMI1 CCNE1 PMC4520755__F3 Canonical Wnt signalling pathway and pharmacological inhibitors under investigation in cancer MMP7 COX2 APC LRP5 CD44 CCND1 LRP6 HNF1A PPARG BCL9 PMC3531707__F3 PERK signaling under virus attack ELF2 ATF4 XBP1 PMC7456554__F3 Toll-like receptor (TLR) pathways deregulated in systemic sclerosis (SSc) TBK1 CD14 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TIRAP MAL PMC9095362__F2 Cancer Stem Cell-Derived Exosomes in Cancer Progression COL18A1 THBS2 ERBB2 ERBB3 CRP PTEN STAT3 PMC7996755__F2 Targeting Nrf2 signaling pathway in chemoprotection KEAP1 ORM1 PMC9095362__F3 Cancer Stem Cell-Derived Exosomes in Cancer Progression PTEN CDH2 PMC7996755__F3 Nrf2 signaling in mediating DOX resistance of cancer cells CD44 LPA PMC9095362__F1 Cancer Stem Cell-Derived Exosomes in Cancer Progression RECK PTEN ACTN4 DGKA PMC7996755__F1 Schematic presentation of Nrf2 signaling pathway GCLM KEAP1 GCLC RBX1 PMC9656931__F10 Protective Effect of the Polysaccharides from Taraxacum mongolicum Leaf by Modulating the p53 Signaling Pathway in H22 Tumor-Bearing Mice CD19 BAX PMC10510267__F8 MCL’s protection against PD-related peritoneal fibrosis SMAD2 TGFB1 PMC7876405__F1 p38MAPK-MK2 axis is activated in response to diverse inflammatory stimuli TLR4 TRADD IL33 TRAF6 MYD88 TNF MAP3K7IP1 TRAF2 TLR3 TAB3 PMC5058662__F3 RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney TLR4 FOS CD40 CCL5 CCL4 IL6 CD80 TNF JUN IL1B AKT3 CCL3 PMC5923345__F1 NF2/merlin-Hippo signaling cascade dysregulation LIN28B FOXM1 AMOT YAP1 VGLL4 MYC CD44 AJUBA LATS1 LATS2 PLCB4 NF2 CCND1 PMC5923345__F2 Signaling cascades and molecules that affect Hippo pathway signaling and YAP1/TAZ activation in MM cells YAP1 LATS1 RHO MTOR LATS2 PMC6016729__F6 Where Hematopoietic Stem Cells Live: The Bone Marrow Niche DICER1 SBDS PMC4613848__F1 RASSF1A/LATS1/CDK2 pathway upon fork stalling BLM CDK2 BRCA2 ATRIP RAD51 LATS1 ATR WRN PMC6604204__F11 Schematic model of how minocycline may inhibit TNF-Alpha-induced cell fusion MMP3 MMP9 SRC PMC8607372__F3 Cytosolic and nuclear recognition of virus and viral evasion TBK1 DHX58 IRF3 TRIM25 MAVS TRIM65 PMC4613848__F2 RASSF1A regulation of the Hippo pathway in response to DNA damage ATM YAP1 CDK2 LATS1 RAF1 ATR PMC3087924__F1 Autophagy in macrophages MTOR STAT3 PMC8607372__F4 Cytosolic and nuclear recognition of virus and viral evasion TBK1 CGAS IRF3 IFI16 PMC10951359__F6 CGRP-induced anxiety-like behavior through epigenetic regulation of the p-HP1G–KLF11–MAOB–dopamine pathway HP PMC2464594__F4 Oct-4 Targets in the Wnt Signalling Pathway NLK SIAH1 APC GSK3B PROC LRP5 CER1 LRP6 SKP1 RBX1 PPARG PMC5270432__F4 rno-miRNA-mRNA network affecting VEGF signaling pathway based on the first global prediction.VEGF: Vascular endothelial growth factor NFATC4 MAPK3 NRAS PLA2G2C MAPK14 SPHK2 PRKCA CASP9 MAPK1 MAPKAPK2 NFAT5 CHP2 NFATC3 SHC2 NFATC2 PPP3R1 PRKCB PLA2G4B PLA2G5 PLA2G2D SPHK1 MAPKAPK3 RAF1 MAPK11 PLA2G2A PXN PLA2G10 PIK3R2 PMC5791370__F4 Proteomic analysis of the genes in Xllp08 and wild-type E PPY CIT SDHA MAL SDHB PMC9572368__F2 Ubiquitin–Proteasome System (UPS) and Viral Infection in Plants SKP1 RBX1 NBR1 PMC8607372__F1 Cytosolic and nuclear recognition of virus and viral evasion TBK1 NLRP3 DHX58 DDX19A IRF3 IFIT5 TRIM25 MAVS TRIM65 IFIT1 PMC8607372__F2 Cytosolic and nuclear recognition of virus and viral evasion TBK1 CGAS TREX1 DHX36 IRF3 MYD88 NLRC3 IFI16 PMC5238783__F2 miR-22 services as onco-miRNA to promote tumor malignant transformation MAPK1 PTEN CCND2 PMC7343820__F8 AChR antibody-induced effects on myotubes expressing AChR clusters MUSK LRP4 PMC6945172__F5 Schematic of fatty acid Beta-oxidation, oxidative stress response and cholesterol absorption processes in the enterocytes of mouse LOC51064 ABCG8 ABCG5 NPC1L1 GSTM3 MTTP CD36 ACAT2 PMC2698322__F4 Key proteins regulated by PKB that are involved in metabolism (yellow); cell cycle progression (green); cellular growth (red); cell survival and apoptosis (blue); angiogenesis (orange) and neurological processes (purple) TSC2 BAD TSC1 MDM2 PMC4589385__F1 Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer PIK3R1 PLCG1 MAPKAPK2 BAD PPP3CA PTGS2 VEGFA RAC1 HRAS SPHK2 HEL-S-102 SHC2 SH2D2A NFATC2 MAP2K1 PRKCB KDR SRC CASP9 MAPK1 RAF1 PXN CDC42 AKT3 PMC2698322__F3 Complex relationship between PI3-K, mTOR and PKB signalling TSC2 RICTOR TSC1 PTEN MTOR RHEB MLST8 PMC4632950__F3 Molecular complexes involved in the calcium signaling pathways responded to BPS and WEX treatments ASPH HEL-S-99n AKAP5 TRDN PMC8032655__F6 Cell cycle at high altitudes (The purple boxes represent enzymes or genes, green box represent down-regulated) EGF GRB2 INS SMAD4 PTEN INSR PMC9260044__F2 Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target FOXM1 TFCP2 SOX9 PMC4632950__F2 Molecular complexes involved in the integrin-linked kinase signaling pathway responded to BPS and WEX treatments NCK2 BMP2 HEL-S-28 PTEN HIF1A MTOR PMC8874522__F2 Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models HEL70 DRD1 DRD2 PMC7671463__F3 Cell signalling influences immune response and resistance to immunotherapy MTOR IFNG PMC7359798__F2 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids TBK1 IFIT2 NLRP6 DHX36 TRAF6 DHX15 IFIT5 MYD88 TASL NLRP9 ZBP1 IFIT1B DHX29 RNASEL NLRP3 TLR8 RNASE1 TLR7 RNASE2 IRF7 RIPK3 IRF3 TLR3 RNASET2 DCP2 XRN1 TRAF2 FADD MLKL MAVS IFIT1 PMC9331395__F6 Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase MSH6 PARP2 PARP1 PARG MSH2 PMS2 PMC7359798__F3 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids TBK1 CGAS TLR9 TRAF6 MYD88 PLD4 PLD3 TASL NLRP3 IL16 BCL10 DNASE2 RAD50 ZCCHC3 AIM2 TFAM IFI16 HMGB1 IRF7 NONO IRF3 APOBEC3F CARD9 APEH TREX1 MAVS PMC6953032__F3 JNK pathways controlling contradictory responses in neurons SPRR1A KIF6 ATF2 ATF3 PMC11626976__F6 Interaction role between TRIM family and p53 signaling pathway in GI cancer TRIM67 TRIM32 MDM2 TRIM28 TRIM24 TRIM39 TRIM25 TRIM59 TRIM23 PMC11626976__F4 Interaction role between TRIM family and STAT3 signaling pathway in GI cancer TRIM14 TRIM52 MMP2 TRIM66 MMP9 SPHK1 TRIM27 TRIM29 STAT3 PMC11626976__F5 The TRIM family in the TGFB signaling pathway in GI cancer CCL15 SMAD2 SMAD4 TRIM47 TRIM25 PMC11626976__F2 Interaction role between TRIM family and Akt signaling pathway in GI cancer TRIM14 TRIM32 PTEN TRIM24 TRIM27 TRIM44 TRIM59 PMC11626976__F3 Interaction role between TRIM family and Wnt/Beta-catenin signaling pathway in GI cancer TRIM11 MMP7 CARM1 TRIM32 TRIM50 TRIM58 APC TRIM15 CCND1 TRIM28 TRIM24 TRIM29 PMC3670242__F1 JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective AK2 STAT3 PMC8310348__F1 Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems TBK1 CGAS TLR9 IRF7 IRF3 MYD88 TLR3 TLR8 TLR7 AIM2 IL1B MAVS IFI16 PMC6543669__F2 LncRNA/pseudogene–miRNA–mRNA ceRNA network in CRC L1CAM HOMER1 PCDH7 MEIS1 STX1A TMPRSS3 FGFR2 NTN1 SNCG FGFR1 SOX12 PID1 GGCT HELLS FOSL1 APC PI15 DPYSL3 NCAM1 VAMP2 AMOTL1 LRP11 BCL2 TNS1 TMEPAI PLEK MYLK ARNT2 AKT3 OLFM1 HAPLN3 CD48 LPAR1 EPHB4 FST ABCB6 CYP26B1 CIDEC SRPX RIPOR2 RBM28 ZFP82 SOBP GNAL CHPF RASSF2 RIMS3 SCML1 ADAMTSL3 FGF7 SCARA3 ZER1 SLC30A4 KCTD1 ATP11A RUNDC3B PITX2 HECW2 FGF2 KCTD12 SNRPF PLPP3 UST NRG1 SIDT2 STC1 EDIL3 AGAP3 ZNF662 WWTR1 ATP8B2 TARBP1 RNF125 TTLL7 TSPAN18 ZNF655 OSBPL1A CPEB2 SPG20 CSF1 PMC7445374__F2 Contact system in disease states A2M PLG C1S C4A PMC3245550__F2 Arf Family G Proteins and their regulators: roles in membrane transport, development and disease ASAP1 ARL1 ARF5 ARF4 ARF3 ARF1 GBF1 PMC7998362__F7 Four identified pathways responsible for P TH SPR PTS FECH UROD UROS CPOX TYRP1 XDH PAH PMC3527886__F2 Network of biglycan signaling in osteoblast differentiation and stabilizing role of biglycan in skeletal muscle WNT3A SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7818013__F1 DNA double-strand break repair pathway choice: a new focus on 53BP1 RNF168 ME2 RNF8 RIF1 ATM MDC1 PMC8783345__F4 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease RELA PMC8783345__F5 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease TH PROC MAL PMC6769485__F2 Anti-apoptotic and cell survival activities of some HSPs in cancer PAF1 BAX PMC6769485__F3 HSP90 functions as a mediator of many oncogenic and signaling pathways APC EGFR GSK3B SRC BCL2 FADD CDC42 STAT3 BAX PMC6580974__F9 Network diagram displaying the IAV-dependent phosphorylation changes in the actin cytoskeleton and focal adhesion KEGG pathways BAD PC F2 APC INS ARHA PTEN JUN CR1 PXN PMC12055712__F8 Model illustrating the regulatory role of Roraa in circadian rhythms and metabolism RORC TEF BMAL2 NFIL3 RORB PER2 PER3 PMC8783345__F6 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease TH POR MAL PMC8783345__F7 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease MOK CP MAL PMC10530670__F5 Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes ATM BIK APP CASP2 CAD TNF DIABLO FADD PMC6354076__F1 Sirtuins and metabolism SIRT2 SIRT7 SIRT4 SIRT5 SIRT6 SIRT1 SIRT3 PMC6354076__F2 Sirtuins and B lymphocytes SIRT2 BCR CD5 SIRT4 PREB SIRT6 GC SIRT1 SIRT3 PMC6329746__F6 Molecular signaling pathways relevant to the resistance to MAPK pathway inhibitors CDK4 RPS6 MTOR CDK6 PMC7920740__F3 Description of antioxidant enzyme system regulation via the Keap1-Nrf2-ARE pathway MAF KEAP1 PMC3294214__F2 Signaling pathways regulating epithelial immune response in nematode epidermal (a) and intestinal (b) cells, adapted from Tan and Shapira SGK1 PMC7818013__F3 DNA double-strand break repair pathway choice: a new focus on 53BP1 RNF168 RNF8 RIF1 MDC1 RAD51 BRCA1 PMC6471594__F2 Cilia-dependent regulation of the Hedgehog signaling pathway SUFU PTCH1 SMO PMC6471594__F3 Cilia-dependent regulation of PDGFRA signaling pathway PI3 PDGFRA IFT20 PMC7906909__F8 Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer F2 RAD51 MTOR BAX PMC7762141__F2 Host immune response against P CS TLR9 NOD1 CCR6 CCR4 IRF3 MYD88 IL1B TIRAP PMC7045519__F3 Epigenetic regulators in ferroptosis ELAVL1 FADS2 WDR76 BAP1 PMC3136937__F4 Identification and Analysis of Signaling Networks Potentially Involved in Breast Carcinoma Metastasis to the Brain HSBP1 NASP VHL ENG RPS10 TRIAP1 ASB9 PGLYRP1 ZMAT3 HNRNPA2B1 CDC37L1 HEL113 RPS3 HSPA1A PMC3847901__F2 Rat sarcoma viral oncogene homolog (RAS) activation converts normal keratinocytes to an initiated phenotype through a series of potentially reversible autocrine signals EGF CXCL1 FYN MMP9 EGFR SRC IL8RB CXCL6 CXCL2 MYD88 PMC6621562__F1 Ubiquitin regulations on mTOR signaling components NPRL2 ULK1 C16orf35 FLCN DEPDC5 TBC1D7 CASTOR1 PTEN RAC1 MTOR DEPTOR IRS1 RHEB TSC2 RICTOR TSC1 TFEB SH3BP4 SZT2 ITFG2 SGK1 PHLPP1 PMC3847901__F3 Divergent roles of myeloid differentiation factor 88 (MyD88) in colon carcinogenesis NLRP3 NLRP6 MYD88 PMC7045519__F1 Known function of organelles in ferroptosis GCA RIPK1 GPX4 FACL4 SLC7A11 ATF4 CHAC1 ARF1 STAT3 PMC4180336__F2 Bile acid biosynthetic pathways CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC5111231__F2 Hypothetical pathway regulating the response of skeletal slow twitch muscle to endurance training: myogenesis, fuel usage, and myosin fiber type change MBTPS1 HIF1A MEF2C MYOD1 MAL PMC4132015__F5 Notch, TGF-Beta, Wnt, Hedgehog, JAK-STAT and MAPK pathways NUMB EPO NODAL EGFR TGFBR1 RAB23 SMAD4 GAS1 HES1 IFNG HES5 FST PIM1 IL2 SMO THBS1 ZIC2 SP1 PITX2 APC SKP1 ARHA IL6 LTBP1 NLK SUFU IL3 CP PMC9136572__F3 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases NLRP3 S1PR2 TLR4 OMP CD36 DFNA5 PMC8137523__F1 Inhibition of the mevalonate pathway by statins affects several outputs and lipid-regulating transcription factors NUS1 MVK IDI1 HMGCS1 ACSS2 RHO IPP GGPS1 HMGCR PMVK INSIG1 MVD FDPS FDFT1 LDLR UBIAD1 ACLY PDSS1 PMC8137523__F2 Oncogenic signaling pathways play a dual role in generating tumor hallmarks that increase demand for mevalonate pathway intermediates while concurrently upregulating mevalonate pathway meet the demand GRB2 RHO ACLY PMC7550403__F1 Pathways of complement activation with complement regulators and inhibitors highlighted HEL-S-62p CD59 C4B_2 CD46 VTN FH CD55 C4A CP PMC4831273__F9 How the source and context of activated GAs and cAMP may determine whether they enhance or inhibit TCR-stimulated IL-2 transcription PLCG1 HEL-S-11 LCK LAT PMC4180336__F5 Bile acid feedback inhibition of bile acid synthesis CYP8B1 HNF4A FGF19 FGFR4 PMC9136572__F2 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases GCA ANGPTL3 NPC1L1 TG NR1C1 CYP7A1 INSR FOXA2 CYP27A1 VLDLR CYP8B1 PLTP LDLR FGF19 APOE PMC9277228__F2 Necroptosis and Neuroinflammation in Retinal Degeneration TBK1 RIPK1 TRADD SHARPIN RIPK3 MYD88 TRAF2 FADD MLKL PMC1855990__F2 Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis KIT CREBBP PMC8137523__F5 Prenyltransferase biology is key to identifying targets of statin anti-cancer effects SKP1 RHO FNTA PTAR1 RABGGTB RABGGTA PMC8137523__F6 Rational combinations enhancing the effects of statins at the mitochondria GPX4 BCL2 ABCA1 DHODH BAX PMC8137523__F4 Tumor suppressors act as a checkpoint for mevalonate pathway flux by suppressing SREBP activity PML INSIG1 KIF3A VHL PTEN ABCA1 PMC5343835__F3 Proposed interaction of AQP1 with Wnt/ Beta-catenin signalling and cadherin-catenin complex AQP1 APC GSK3B LRP5 CCND1 LRP6 PMC2817557__F2 Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota TLR4 LBP IRF3 IRAK4 CSA2 NOD2 TIRAP PMC5872357__F1 Epac signalosome in cardiac hypertrophy and ischemia GHRHR RYR2 GHRH PMC5584153__F4 Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis EGF BAD FGF2 CXCL8 CCND1 PTEN PMC4171211__F11 Proposed model of tetrandrine-induced apoptosis in prostate cancer FADD BAX PMC9166517__F8 Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis CD14 EGF TRADD DAO FLNA GCK TNF NLK MAX HP GRB2 JUND ECSIT TRAF2 PMC8103031__F2 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases MYB FOXM1 FOS RUVBL1 ERBB3 FGFR3 POLR2H NME3 UBC RHOD VAV3 RAC3 MCM2 FOXA1 ERBB2 TFF1 CCND1 CA12 JUN BCL9 PCNA CENPA CD68 VAV2 PMC8103031__F3 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases MYB MAPKAPK2 RAC3 ERBB2 ERBB3 CDC25B VAV2 PMC10860311__F1 Ovarian clear cell cancer carcinogenesis PIK3CA PTEN ARID1A PMC7693401__F2 Toll-like 4 receptor signaling in MCs CD14 FYN TLR4 VAMP3 IRAK1 ATF2 LYN TRAF6 IRAK4 MYD88 TNF SNAP23 PMC7693401__F3 Control of TLR4-mediated signaling in MCs TLR4 SOCS3 IRAK1 ATF2 TRAF6 IRAK4 MYD88 SNAP23 SOCS1 PMC5094751__F12 Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells CLEC18B EREG SYNE2 GLIPR2 UTY ADAMTS9 GPR179 POSTN GPRIN2 TROAP RNF213 CSMD2 TMEM158 SAA1 EBPL ADAM19 RNF183 CRLF1 MMP7 HPGD TIMP3 BRK1 RAP1GAP NOTCH2 DPYSL3 HBEGF HMGCR NTF3 VEGFC ITGB4 EDNRA DET1 BCL2 SPHK1 ABCA1 CP CXCL1 TPM1 PTN TGFBR1 NEF3 NOX4 NEFH PDLIM7 CLU SYTL2 ARG2 SFRP1 F2RL2 FGF2 MMP9 HS3ST2 CFTR HLA-DPB1 CTNND2 ACSL3 PMC9372913__F8 WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro TCF3 ATF2 APC LRP5 CD44 LRP6 CELSR1 RHO RAC1 MTOR TLE4 JUN TLE2 TCF4 PMC7693401__F4 Molecular events involved in the response of MCs to mediators produced by cell damage and stress HMGB1 FYN TLR4 IL33 MYD88 TNF HIF1A PMC3864445__F2 Fermentative hydrogen production from glucose by E MAX HEL-S-133P PMC6771012__F3 Molecules and cellular pathways that contribute to thyroid cancer development RET BRAF ALK APC GSK3B MDM2 PTEN MTOR TERT PMC2658537__F1 Sample signalling scheme showing pathways known to be active in melanoma TSC2 BAD TSC1 BRAF PTEN MTOR PMC3233530__F2 Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis PIK3R1 BRAF NODAL TGFBR1 SMAD4 RB1 CREBBP SMARCA4 ACVR2A BMPR1A ACVR1B GRB2 RAF1 HEL-S-93 SMAD1 PPP2R2A PMC4531430__F6 miRNA–gene–pathway regulatory networks VAV3 FACL4 GHR FGF12 TNLG2B CXCL12 PRKAB2 LAMC2 HMGCR MYLK ITGA2 PMC4909106__F4 Innate sensing of Toxoplasma gondii and Plasmodium sp TLR7 TLR9 IRF7 IRF8 IRF3 MYD88 MAVS PMC10572711__F2 Major and other possible molecular pathways associated with NLRs in IBD ATG16L1 NLRC4 MAPK8 NLRP1 IRAK1 NLRP12 NLRX1 MAPK14 NLRP6 TRAF6 MYD88 NOD2 NLRP7 GSDMD NLRP3 CARD9 TLR4 MAVS PMC6326574__F1 Immunological mechanisms responsible for radiation-induced abscopal effect CGAS APC IRF3 MX1 PMC8517268__F7 Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration METTL14 YTHDF1 METTL3 PMC6914705__F10 Schematic representation of how SteA suppresses the nuclear factor kappa B (NFKB) pathway CAND1 SKP1 NEDD8 PMC3478886__F1 Prognostic Value of Cell-Cycle Regulation Biomarkers in Bladder Cancer ERBB2 CDK2 EGFR MDM2 CCND1 CDK4 CDKN2A PMC3109595__F5 Gene regulatory network model for specification of the skeletogenic mesoderm lineage NRL ERG FOXN3 FOXN2 HEL23 PMC8250126__F1 Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection JAK1 TNF ACE2 PMC6152668__F3 DET- and IDET-induced apoptosis in different cancer cell lines MTOR FADD BAX PMC8861201__F1 Metabolic Engineering for Valorization of Agri- and Aqua-Culture Sidestreams for Production of Nitrogenous Compounds by Corynebacterium glutamicum NOG CIT MAL PMC7947867__F4 Model showing plasma membrane NKCC1 and mitochondrial respiration: a link through leucine? Aerobic respiration utilizes the KREBS cycle and the electron transport chain XBP1 IRS1 DNAJC3 PMC8761794__F2 CGAS/STING Pathway: A Novel Target for Cancer Therapy CGAS CXCL10 NOS2 TNF CXCL11 SLC19A1 PMC8761794__F3 CGAS/STING Pathway: A Novel Target for Cancer Therapy TBK1 CGAS IRF3 PMC8761794__F1 CGAS/STING Pathway: A Novel Target for Cancer Therapy TBK1 STAT1 OAS1 STAT2 CXCL10 IRF3 CCL5 IFNAR2 TNF IFNAR1 PMC10526343__F1 Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments VCAM1 APC PMC4748726__F4 Network of osteogenic specific proteins regulated by BMP2 signaling SPARC ALPL RUNX2 BMP2 opn COL1A2 IBSP COL1A1 BGLAP PMC9563116__F2 Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis BOC LATS1 RHO LATS2 PMC9628242__F6 Tetrahedral framework nucleic acids promote diabetic wound healing via the Wnt signalling pathway LEF1 VEGFA CCND1 PMC8835964__F8 Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer EIF2S1 BAK1 OMA1 ATF5 BCL2L11 EIF2AK1 DDIT3 STOML2 DELE1 BBC3 ATF4 PMAIP1 MCL1 PHB2 OPA1 BAX PMC8424636__F7 Nicorandil inhibits TLR4/MyD88/NFKB/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction NLRP3 TLR4 MYD88 GSDMD PMC10565453__F2 Organelle-level mechanisms of mitochondrial quality control TH MFF NRF1 POC1A SIRT1 FIS1 OPA1 PMC7827341__F2 IL-1A signaling pathway IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC8143883__F6 MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2 ANXA2 MTOR PMC10565453__F3 Altered mitochondrial quality control in renal tubule cells under high glucose conditions MFN1 NRF1 MIOX MTOR SIRT3 PINK1 PACS2 CXCR4 TXNIP PGAM5 PHB2 TFAM FIS1 STAT3 OPA1 PMC7713123__F1 Pathway engineering in yeast for synthesizing the complex polyketide bikaverin HEL-S-49 CLC RPS2 ENO2 HEL-S-68p PMC12134904__F5 IL-2 Action JAK3 PTEN JAK1 MTOR FOXP3 PMC10298860__F11 Albino phenotype of ‘HJY’ might be modulated by a plastid retrograde signaling pathway PPCS POR PMC8471942__F1 Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic XRCC5 ATM RAD51 ERCC1 ATR PRKDC PMC4127075__F1 Regulation of EMT by KLF4 in Gastrointestinal Cancer CDX2 FOXM1 SPRR2A IFITM3 CCNB1 KLF4 CCND1 BMI1 KRT4 PMC4127075__F2 Regulation of EMT by KLF4 in Gastrointestinal Cancer NOTCH2 EGF SMAD2 EGFR KLF4 SMAD4 NOTCH1 CDH2 MTOR STAT3 PMC9273993__F3 Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer CXCR1 IL8RB MTOR PMC9877271__F1 Unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs ATF4 ATF3 PMC8515174__F2 Complement inhibition for the treatment of COVID-19 triggered thrombotic microangiopathy with cardiac failure: a case report ADAMTS13 MIA PMC6310057__F1 Potential targets of glucose metabolism for anticancer therapy HEL-S-133P HEL-S-162eP PMC6769561__F2 Schematic summarizing the molecular mechanisms contributing to cancer progression FREP1 EGFR STAT3 PMC5751948__F1 Activation of NFKB (nuclear factorKB) by canonical and atypical pathways LTA PC BCL10 RELA RELB TNF MAP3K7IP1 PMC2395050__F1 PG-recycling pathway of the wild type (A) and trapping of anhMurNAc-tripeptide in an ampD mutant (B) DAP MPL PMC10935119__F9 Enzastaurin, midostaurin, and lestaurtinib PTEN FLT3 MTOR PMC5447271__F1 Illustration of Wnt signaling cascades NLK APC GSK3B AXIN1 LRP5 PMC9380940__F3 Causal network predicted for STAT3 regulator showing its relationship with obesity and inflammatory response, obtained using Ingenuity Pathway Analysis (IPA) POMC CDKN2B STAT3 PMC7821690__F1 Crosstalk Signaling and miRNA Deregulation in Obesity Related Breast Cancer HMGA2 BAD FOS MDM2 SRC PTEN FOXO1 STAT3 PMC4329227__F2 Pentose phosphate pathway and cancer TIGAR ATM MYC SRC MTOR HEL107 RPE PMC12076877__F3 Aryl hydrocarbon receptor: a new frontier in male reproductive system AHRR AHR PMC4884395__F1 Kynurenine pathway of tryptophan metabolism KYNU GFAP IDO2 IL6 IL1B PMC4344557__F2 Proposed mechanism of action of yerba maté on the modulation of the PI3K-AKT signaling pathway IRS1 PMC4773443__F5 Metabolic intermediates regulate Yersinia virulence RELA CRP HPR PMC9268458__F1 Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research NR1i1 CYP2R1 DHCR7 GC PMC3629228__F2 De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development NODAL MYC SMAD4 ARHA PTEN IFNG FST TSC2 CASP3 PERP ATM CDK2 SKA1 THBS1 ATR PMC11201201__F2 VEGFR activation by the VEGF family of growth factors and resulting downstream signaling pathways to angiogenesis and lymphangiogenesis PIGF VEGFC VEGFA MTOR VEGFB PMC4149734__F5 Turnover of proteins in metabolic pathways in barley leaves PGP POR HPR PMC8001935__F3 PPI-specific gene-regulatory networks of top 5 KDs in IGF-I and IR (eQTL mapping) PRKCZ PPP3CA INSR ERBB4 BCR KLC2 CDH2 YWHAG CGN RAB11A NCL FES ATP2A1 HRAS IRS1 PTPRF PLCB1 PIK3R5 FER MAP2K1 GRB2 PPP2CA OTX2 RPS3 CSNK2B ITCH PMC7961896__F2 Unfolded protein response (UPR) pathways in skeletal muscle ATF4 EIF2A TRAF2 PMC3024731__F2 Examples of the signaling role of Cdc42 in selective tissue cell types INS CDC42 ELL PMC7961896__F1 Molecular mechanisms regulating skeletal muscle mass ELF2 IGF1R SMAD2 ATF2 SMAD6 BMP7 PTEN MTOR RHEB TSC2 MAF RICTOR IGF1 BNIP3 GDF11 TRAF2 PMC9474891__F2 Role and regulatory mechanism of m6A methylation in the nervous system METTL14 METTL3 FOXM1 HNRNPC HNRNPA2B1 IGFBP2 ADRB2 SRSF7 WTAP MTOR HK2 PMC9335447__F6A MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study PIK3R1 BAMBI KIT BMP2 VEGFA ARHA COCH IFNG RPS6KB1 KDR SKA1 REL NTRK2 SHC1 PMC7372882__F7 PI3K-AKT signaling pathway plays a central role in anti-TAO system of SP EGF BAD PTGS2 MAPK3 VEGFA INS CXCL2 BCL2L1 PTEN RAC1 TNF CASP10 IRS1 INSR TNFSF6 ITGB4 MDM2 GRB2 IL2 BCL2 MCL1 PMC5264313__F4 Microarray analysis reveals alterations in the expression of major pathways of cellular metabolism in response to changes in collagen extracellular matrix density.A SHMT1 PSPH HEL-S-51e HIF1A PHGDH HEL-S-32 PMC8189684__F3 MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations NPM1 KEAP1 EGFR NFE2L2 CDK12 PTEN MTOR CDKN2A BRCA1 HEL-S-26 NF1 SMC1A MDM2 PIK3CA PMC7257216__F8 Schematic diagram illustrating the mechanism by which asiaticoside inhibited MMT and ROS generation SMAD2 SMAD4 TGFB1 PMC4786634__F1 Both signal 1 and signal 2 are required for NLRP3 inflammasome activation NLRP3 MFN2 TXNIP MYD88 IL1B MAVS PMC5706502__F5 NcRNAs involved in mTOR signalling pathway TSC2 IGF1R LAMTOR3 PTEN DEPTOR IRS1 RHEB PMC4352384__F5 Polymicrobial synergy and dysbiosis in inflammatory disease ARHA MYD88 TLR1 SMURF1 MAL PMC4352384__F6 Polymicrobial synergy and dysbiosis in inflammatory disease NLRP3 TLR4 CXCR4 GSK3B TLR1 IL1B PMC8444018__F4 Temporary Regulatory Deviations and the Coronavirus Disease 2019 (COVID-19) PCR Labeling Update Study Indicate What Laboratory-Developed Test Regulation by the US Food and Drug Administration (FDA) Could Look Like APC IVD PMC10840489__F3 Endosomal and cytoplasmic viral RNA sensing by RLRs and TLRs TLR7 IRF7 IRF3 MYD88 TLR3 MAVS PMC11758981__F1 Gut microbial regulation of lipids reflects the influence of gut microbiota on hyperlipidemia in various treatment methods ANGPTL3 LPL ANGPTL8 PMC4367433__F2 Pathway for protein modification by UFM1 UFM1 UFL1 UBA5 UFC1 PMC10604364__F3 Illustration depicting the formation and fate of hybrid cells TLR4 MSC PMC4367433__F4 Pathway for estrogen-induced ASC1 ufmylation for ERA transactivation UFM1 SP2 CCND1 PMC6027295__F1 Main signaling pathways of adiponectin in healthy liver ADIPOR1 ADIPOR2 NR1C1 PMC4440546__F5 Context-dependent control of alternative splicing by RNA-binding proteins EGFR FASTK PMC1895802__F1 TGFB signaling pathway and mechanisms of inhibition during leukemogenesis SMAD2 SMAD6 SMAD4 PMC7273480__F9 Metabolic pathway analysis SI SHE MOK PMC7457738__F8 Proposed schematic representation for GAST in GC development and progression MMP11 SRC GAST STAT3 PMC3924831__F2 Apoptosis signaling under ER stress conditions ATF4 EIF2A TRAF2 BAX PMC6133308__F1 KEAP1-NRF2 pathway is altered in human lung cancers.Schematic of KEAP1-NRF2 pathway under homeostatic conditions (left), oxidative conditions (center) or synergistic conditions, for example in a cancer cell (right) MAF KEAP1 GSK3B PMC4252505__F3 Hras-Braf MAP-Kinase pathway visualized using GenMAPP software PLCB3 MAP3K1 BRAF MAP2K4 MBP MAPK10 MAPK3 NRAS RRAS MAP2K2 MAP3K12 RASA3 MAP2K1 MAP3K2 SIPA1 MAPK1 RAP1GAP RAF1 JUN ARAF PMC5719347__F7 Signalling pathways associated with PRDXs and hypothetical illustration of PRDXs in mouse spermatozoa HEL-S-2a EGFR HEL-S-128m PRDX3 SRXN1 GLRX HEL-S-22 PMC8851036__F2 Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis TLR4 MPO VCAM1 HEL-S-11 COMP PMC10384495__F2 Molecular and Genetic Interactions between Obesity and Breast Cancer Risk ADIPOR1 ADIPOR2 NR3A2 LEPR MTOR STAT3 PMC6667461__F1 Overview of direct and indirect pro-allergenic immune responses to anti-ulcer drugs (AUD) TH AHR FRK HEL-S-92n IL6 PMC5613156__F3 NOD-like receptors control various forms of PCD in mammals and filamentous fungi NLRP3 APAF1 TPR GLTP NWD2 PMC2803786__F2 Network analysis of the top 250 predictor genes CACNA2D2 SUMO3 DUSP4 IRF9 VPS16 MYCBP SAA1 CEBPG KRT6B HLA-F GBP1 AMFR HTATSF1 AHR VAMP3 WASL HEL-S-2 CXCR4 CAV2 SSRP1 RHOB HSPA4 PMC2198843__F1 Adhesion regulation of nucleocytoplasmic trafficking of signaling molecules LEF1 HEL-S-28 APC CASK PMC8575484__F3 Identification of Candidate Genes Related to Synovial Macrophages in Rheumatoid Arthritis by Bioinformatics Analysis BAD MAL PMC9467755__F2 Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future NLRP3 HMGB1 IL6 PMC10313304__F9 Exploring the active ingredients and mechanism of Shenzhi Tongxin capsule against microvascular angina based on network pharmacology and molecular docking CD14 NLK MAX TRADD FRK FLNA JUND RAF1 TNF TRAF2 MEF2C MPL PMC3784473__F9 The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites LIPA IPP PMC7122562__F2 Viral infection suppresses autophagy ULK1 ATG3 IRS1 PMC7122562__F3 Viruses manipulate autophagy to promote their replication ATG12 ATG3 IRGM ARF1 SNAP29 DKFZp686F0183 TSC2 TUFM EDEM1 UVRAG STX17 GBF1 MAVS PMC4562884__F1 Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development APC LRP5 LRP6 ROR2 RHO PMC8185109__F3 Mitochondrial ER contact sites in neurodegeneration PINK1 VAPB MFN2 PC GSK3B APP MCU DKFZp686F0183 FUS PSD PMC10530616__F15 Schematic illustration for the effects of Actinidia deliciosa (kiwi) extract on pathways related to T2DM BAD KEAP1 GSK3B PTEN SIRT1 STAT3 PMC7891678__F1 TGFB as a gatekeeper of BMP action in the developing growth plate ACVRL1 SMAD2 TGFBR1 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC8727908__F2 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling SNAI1 MMP9 RELA IL6 BRD4 PMC8692109__F8 Human Alpha-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway EGF DEF6 CCNA2 EGFR PMC8727908__F5 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling SMARCA4 MMP9 RELA POLL CDK9 POLI BRD4 PMC8727908__F6 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling MED4 MMP9 RELA ARID1A BRD4 PMC3812255__F2 Serotonin Gene Variants are Unlikely to Play a Significant Role in the Pathogenesis of the Sudden Infant Death Syndrome FEV HTT TPH2 PMC11748645__F8 PD-L1 monoclonal antibody improves left ventricular function by modulating the CD47/SHP2/SIRPA/SYK/FcGR signaling pathway in tumor-associated macrophages, thereby inhibiting cGAMP expression NLRP3 CGAS CD47 SYK IRF3 PMC8727908__F8 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling MMP9 NOX4 IL6 PMC5529431__F5 Representation of the putative signaling pathways involved in B-cell clonogenicity induced by interaction of S75X/p17R76G with p17R(s) CHEK2 PAK1 PAX2 CDK2 CASP9 CDC2 HEL-S-93 PMC11748645__F5 PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPA/SYK/FcGR signalings in tumor associated macrophages SIRPA CD47 MYC SYK STAT3 PMC1483167__F1 Liver X receptor opens a new gateway to StAR and to steroid hormones LDLR CYP11A1 ABCA1 PMC3815023__F2 Functional Networking of Human Divergently Paired Genes (DPGs) ISY1 SMAD4 PUF60 MAGOH STAP2 AQR CCDC12 NHP2L1 CDC20 CHERP CDC6 CDK2 STAP1 RBM22 PCNA SKP2 MYT1 PMC12250376__F9 Overexpression of (P)RR in SHR and Renin-Induced HepG2 Cells Leads to Spontaneous Hypertension Combined with Metabolic Dysfunction-Associated Fatty Liver Disease TG FASN CD36 PMC11955602__F0 Diagram illustrates how herbal formulations and extracts derived from TCM exert potential effects on AD through modulation of the PI3K/AKT signaling pathway BAD PTEN BAX PMC9600997__F8 TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40 TRAF1 TRAF3 TRAF6 CD40 BAX PMC6826992__F9 Models of EGFR-ligand dependent pathway and EGFR-ligand independent pathway in EIS cells ERBB3 EGFR SRC PMC2891338__F1 Endotoxin binding: Schematic overview of the LPS, LBP, CD14 and TLR-4 signal transduction pathway TLR4 LBP TRAF6 IL6 MYD88 PMC7042390__F9 Wnt signaling pathway NLK WNT4 APC WNT7A WNT1 GSK3B LRP5 LRP6 ARHA WNT7B PMC6617733__F1 Distinct molecular and morphologic features of apoptotic, necroptotic, and necrotic cell death CAP2 TRADD CYLD TRAF2 FADD MLKL RFWD2 PMC3410255__F1 Regulation of PTEN/PI3K/AKT pathway by microRNAs IGF1 CCND1 PTEN PMC4879160__F4 Sclerostin actions LRP4 LRP5 LRP6 PTH PMC12000830__F2 Regulatory role of MEG3 in cancer progression and suppression IL18 RASL11B PTPN11 IL6 PTEN PMC9004513__F1 MTORC1 Activity by Amino Acids and Growth Factors TSC2 NPC1 FLCN TSC1 SLC38A9 MCRS1 TBC1D7 CASTOR1 MTOR RHEB MLST8 PMC12000830__F3 MEG3 lncRNA: a key regulator of tumor suppression across multiple cancer pathways MMP2 MMP9 MTOR STAT3 BAX PMC10151763__F2 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy KL RUNX2 BMP2 WNT7B PMC6458732__F6 A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions IL6 MTOR IRS1 STAT3 PMC10151763__F1 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy ADAM8 EGR1 TLR4 FGF23 IGF1R IGF1 SMAD2 SMAD4 ARHA TGFBR3 PMC5543436__F1 a The subcellular localization of the three isocitrate dehydrogenase isoforms and their roles in normal cellular metabolism HEL-S-26 PMC5418193__F1 Insulin/insulin growth factor signaling pathway and its activation by reactive oxygen species (ROS) TSC2 TSC1 PTEN PMC8595768__F3 Oxidative stress-induced damage of IDE and BVR-A is associated with development of brain insulin resistance GSK3B MTOR PMC7407108__F1 Hippo pathway NF2 AMOTL1 VGLL4 LATS1 RHO FRMD6 FAT4 PMC8264455__F1 Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing MAF KEAP1 PMC8595768__F1 Insulin signaling GSK3B GRB2 MTOR IRS1 PMC5382875__F1 Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer CD44 NOTCH1 SIRT1 CDK6 PMC11668677__F6 Summarizing figure for NA protective effect on lung tissues against the toxic effects of radiation NOS2 TNF ARG1 TGFB1 PMC8197487__F7 Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review BAD NGF SHE TRAF6 PTEN NOD2 FOXO1 CARD9 NOD1 FRK CSA2 JUN TF BAX PMC8449777__F7 Schematic showing the mechanisms underlying miR-2337 induction of TGFB1 production in GCs AGO2 TGFBR1 TGFBR2 PMC8198882__F1 Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer’s Disease RICTOR MTOR FOXO1 RHEB PMC4054275__F11 Proposed regulatory mechanism of protein tyrosine phosphatases in C ERG ATF1 TF PMC6930621__F10 Hepatic metabolic pathways of Met VIT PMC8132252__F2 Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19 ADAMTS12 PC VWF HEL-S-5 PMC9513044__F2 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment APC GSK3B STAT3 PMC7249743__F8 Potentially HCC-related KEGG pathways E2F4 DERA SMAD2 MYC SMAD4 PTEN MTOR ORC3 ORC2 CDK7 AIFM2 PERP ATM MDM2 CDK4 CDC2 BAX PIGS CDC45 RFWD2 CASP3 TSC2 IGF1 SMC3 CDK2 ATR SIVA1 PCNA SKP2 PMC9513044__F1 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment NOS2 ARG1 STAT3 PMC9697637__F2 Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases GSK3B CDK5 APP PMC6349152__F1 The role of SUMO in kidney fibrosis TGFBR1 VHL SMAD4 PMC7378533__F2 Type I IFN due to the activation of IFN receptors STAT1 STAT2 TYK2 JAK1 STAT3 PMC3773303__F3 Clathrin-dependent and -independent endocytosis of STx SYK RHO CDC42 PMC5845882__F8 gga-miR-155 and the suppression of IBDV replication TBK1 TANK IRF7 IRF3 TLR3 SOCS1 PMC7759095__F4 SARS-CoV-2 infection and signaling pathways as potential targets for treatment ACE2 TMPRSS2 PMC9057928__F3 Emerging roles of retromer and sorting nexins in the life cycle of viruses VPS35 SNX2 SNX5 SNX27 PMC1904449__F3 In silico modeling derived from Pathway Assist software analysis of differential gene expression in JRA neutrophils compared with healthy control subjects CDA GNLY FES FOSB HEL-75 RALA CD83 PTMA MCL1 TNF ADM TNLG7A PMC7896749__F3 LncRNA‐mediated posttranslational modification of other proteins involved in metabolic pathways MDM2 FUS SIRT1 PMC9576507__F3 Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19 NLRP3 IL16 NLRC4 NLRP1 POR ACE2 AIM2 GSDMD PMC8893235__F2 Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals? ULK1 DES ULK2 BNIP3 BRCA1 PSD PMC5751344__F3 Involvement of galectins during carcinogenesis NRP1 APC GSK3B ARHA HRAS PMC9437339__F9 Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice GLRX2 PLCG1 IL1A NONO TNFRSF6B EGFR NR3C1 APOC3 HBEGF IL1R1 CDC37 LPA APOB AHSA1 EP300 STUB1 HEL-S-64p CD40LG FKBP4 APOA2 SIRT1 IL1B STAT3 CCS PMC2684021__F1 The fungal cell wall and downstream cellular responses following engagement of Dectin-1 and TLRs on antigen presenting cells (APC) IL10 CARD9 APC IL2 SYK IL6 MYD88 TNF PMC7038193__F3 Sp1 mediated tumorigenesis in ovarian cancer (OC) MDM2 SRC CLDN4 SP1 PMC8526690__F3 Mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues AIP HP RUNX2 PIEZO1 ATF4 SOST PTGS2 MSC TNFRSF11B PMC4383556__F9 Transcriptome Analysis and Its Application in Identifying Genes Associated with Fruiting Body Development in Basidiomycete Hypsizygus marmoreus TSC2 RICTOR ACADS DCT TYRP1 HIF1A MTOR COMP EIF4B PMC9460496__F9 Transcriptional Memory in Taraxacum mongolicum in Response to Long-Term Different Grazing Intensities PC FES C6 PMC3703549__F8 Ang II activates the Notch1/Snail signaling, which is responsible for the pathogenesis of proteinuria in diabetic nephropathy NOTCH1 HES1 PMC8911352__F2 Paediatric Behçet’s Disease: A Comprehensive Review with an Emphasis on Monogenic Mimics RIPK1 BCR TRADD RELA SHARPIN OTULIN PMC3697124__F3 Antibiotics doxycycline and minocycline inhibit inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi EGF LTA RELB TIRAP PMC5809464__F9 Lipid metabolic pathway analysis of identified differential lipid species TYW1 PC IMPACT PMC11410975__F0 ALKBH5 activated JAK2/STAT3 signaling pathway and mediated m6A demethylation on Stat3 mRNA, but not Jak2 mRNA, resulting in the phosphorylation and nuclear translocation of STAT3, which enhances the transcription of hypertrophic genes (e NPPA NPPB ALKBH5 STAT3 PMC2821954__F2 Portrayed here is a molecular pathway analysis of genes regulated in the mouse nucleus accumbens by a direct infusion of the HDAC inhibitor MS-275 after chronic social defeat stress IFIT3 STAT2 EGFR REST RHO ADRA1A JAK1 TGFA PMC6826893__F5 Crosstalk between RAS-ERK pathway and FOXM1 TH DUSP10 FOXM1 SKP2 PMC4713713__F3 Activation of autophagy and caspase-independent apoptosis pathway and proposed mechanism of action of magnetic nanoparticles functionalized with LL-37 on colon cancer cells DKFZp686F0183 BAX PMC3019079__F1 The homocysteine and folate metabolic pathway RFC1 MTR MTRR PMC7494756__F1 Output and input pathways of the central circadian timing system in the mammalian brain that may be involved sundowning–related behavioral aggression and circadian dysfunction in Alzheimer’s disease and related dementias NPY AVP VIP PMC9499548__F4 Two Short Repeats in the 5′ Untranslated Region of Insulin-like Androgenic Gland Factor in Procambarus clarkii (PcIAG) That Regulate PcIAG Expression NLK MOS HEL-S-11 JUND ARHA JUN DVL1 PMC8967653__F1 Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins TEAD3 RET APP DCHS1 TEAD4 FBXL7 LATS2 FAT4 TEAD2 PMC7683721__F7 Signaling cascade for the aberrant TRPV4 and calcium activation in endometrial cancer TRPV4 ROCK1 ARHA PXN PMC11972515__F2 LncRNAs in acute myeloid leukemia IGF1R TUG1 PMC4595210__F4 Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice ADORA2B EGR2 GPT2 ARRDC3 MAP2K2 CP HES1 PMC9319091__F11 VMP1 Regulated by chi-miR-124a Effects Goat Myoblast Proliferation, Autophagy, and Apoptosis through the PI3K/ULK1/mTOR Signaling Pathway MTOR VMP1 PMC6721648__F2 Pathways of androgen action in the Sertoli cell EGFR SRC TF PMC5105060__F9 Analysis of Zinc-Exporters Expression in Prostate Cancer CCL4L2 SLC30A9 SLC30A4 SLC30A8 CCL4 DIRAS3 B3GNT3 SLC30A7 SLC30A6 NAPA RBM25 SLC30A2 SLC30A10 SLC30A5 INSR SLC30A1 ELAVL1 CLPSL1 CSF2 SNX27 PMC5094499__F1 Pleiotropic effects of hyperglycaemia‐induced miR‐126 underexpression and insulin resistance SPRED1 PTEN RAF1 IRS1 PMC6685059__F2 Translational challenges with systemic and local cell delivery HEL-S-62p CD9 MREG CS TFPI CD46 MSC TF PMC5418463__F1 Regulatory T (Treg) cells modulate CD8 T‐cell exhaustion, but the programmed cell death protein 1 (PD‐1) pathway determines viral control TNF PMC6778255__F8 Schematic view of the role of AvB3-int in PD-L1 expression and antitumor immunity STAT1 STAT2 JAK1 PMC6266222__F3 Regulatory effects on immune-related pathways induced by a group of compounds from health-strengthening herbs CANX FYN TAP2 REN NFYC GRB2 IFNGR2 B2M IFNGR1 IFNG PMC6938582__F2 Action of metformin in endocrine tumors: metformin is a negatively charged molecule that enters the cell through organic cation transporters (OCTs) TSC2 TSC1 IGF1 EGFR CCND1 ATF3 MTOR IRS1 STAT3 PMC9596769__F3 Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: From predictive fiction toward reality IL10 CCR5 NR1i1 IGF1 IL9 IL22 SHH IL6 IL4 HIF1A PMC6744391__F9 TAAR1 signaling pathway/apoptotic pathway components TAAR1 BAX PMC4084927__F10 Acetaminophen and NAPQI are Toxic to Auditory Cells via Oxidative and Endoplasmic Reticulum Stress-dependent Pathways ATF4 EIF2A XBP1 PMC12060066__F4 Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies VASP BAD GC INS TRPC6 CNP ARHA PMC7198484__F4 Intracellular Staphylococcus aureus persisters upon antibiotic exposure CS LDHD PROC NR1A2 THRA SDHB PMC3280691__F1 Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target APC AXIN1 LRP5 LRP6 AXIN2 PMC7723172__F3 Effects and mechanisms of corosolic acid-induced anti-inflammatory and anti-MS activities NLRP3 IRS1 PMC8625880__F2 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair PALB2 POLE BRCA2 RAD52 RAD51 PARP1 LIG1 BRCA1 PAXX PMC8625880__F3 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair CETN2 XPC ERCC1 XPA DDB2 DDB1 PCNA UVSSA PMC4700926__F1 The core autophagy pathway and its regulation by miRNAs ATG16L1 ATG12 ATG3 TBC1D2 LAMP2 BCL2 UVRAG ATG10 DKFZp686F0183 PMC2758293__F2 An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective FER PATJ HEL-S-28 GSK3B PALS1 SRC CRB3 CDH2 PMC8615762__F1 Chemokine Pathways in Cutaneous Melanoma: Their Modulation by Cancer and Exploitation by the Clinician CCR5 CXCL1 CCR2 EGF HGF CCR6 CXCL5 CCL21 CXCL8 CXCL3 CCL5 CCL2 CCR8 CCL1 CCR10 CCR7 CCL17 CXCL6 CCL25 CCL27 CXCR1 CXCL10 CCR4 IL8RB CXCL2 CCL4 CXCR3 CXCR4 CCL20 CXCL9 CXCL12 CCL22 CCL3 PMC5574038__F6 The role of the Dishevelled DEP domain in Wnt/Beta-catenin signal transduction WNT3A LRP6 PMC7721491__F4 Association of PPARs with neuroinflammation IL6 TNF IFNG PMC6976994__F3 Mechanistic aspects of DME regulation in mouse liver tumors with mutations in either the Ctnnb1, Hras, or Braf oncogene AHR CYP1A1 CYP2E1 PMC9228804__F3 Tumor Suppressive Effects of GAS5 in Cancer Cells CDK2 CCND1 PTEN EIF4E MTOR PMC3882755__F8 A Receptor-Specific Function for Notch2 in Mediating Vascular Smooth Muscle Cell Growth Arrest Through p27kip1 NOTCH2 CDK2 SKP2 PMC5466396__F9 Crosstalk of hypoxia-induced endothelial-mesenchymal transition (EndMT) signaling pathways RUNX3 SMAD2 SMAD4 NOTCH1 PMC9228804__F6 Tumor Suppressive Effects of GAS5 in Cancer Cells TSC2 TSC1 PTEN EIF4E MTOR EIF4B RHEB PMC4682189__F2 Comparative transcriptome analysis of grapevine in response to copper stress UROD UROS CPOX POR PMC8755416__F2 Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy DAO ACE2 IL1B PMC3184987__F5 Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component CD14 EGR1 FCER1G GIG8 FCER1A EGR2 IL13 IRF8 PAX5 ID3 CD19 CD3E PMC9181689__F2 Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease TNF IL1B PMC5465356__F8 ATP-binding cassette transporter A1 regulates phosphoantigen release and VG9VD2 T cell activation by dendritic cells ABCA1 MTOR IPP PMC4991739__F5 Dynamically alternative pathway network TNC BCR PIR CA3 CAV2 PMC7161696__F9 Pathway of hyphal formation LMO1 NRG1 OFD1 CDC42 PMC3091753__F3 Representative genes that responded to [BF/S+L/Ep] treatment RBP1 IKBKG AMOT OSCAR PPBP ACSS1 HTT SP1 SERPINB2 PER2 SLA TWSG1 MAPKAPK2 AHRR NCAM2 DMC1 APC CXCL2 ASB2 NFKB1 SYCP1 NRXN1 RBM14 CDH10 ABCE1 SOX6 PMC5345753__F1 Different molecular mechanisms that can induce time-delay necessary for the generation of oscillations in transcription factor activity MDM2 AXIN2 HES1 PMC6668488__F7 A proposed schematic representation of Mn-dependent adaptive and toxic response pathways ARFGAP3 FABP5 ADAM10 NDUFAF5 BET1 PMC8325099__F7 Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients SMAD2 TGFBR1 TGFBR2 SMAD4 RHO PMC3709248__F4 Nitr9L–Dap12 activation of cytotoxic cells FYN LCK ZAP70 SRC SYK KIR2DS2 PMC1933158__F6 A hypothetical model for the dual roles of insulin signaling in human brain MYC NEUROG2 PMC8306439__F3 Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits TSC2 TSC1 PTEN MTOR IRS1 RHEB PMC3145614__F1 Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium FADS2 FADS1 ELOVL2 PMC5601173__F3 SOCS molecules: the growing players in macrophage polarization and function STAT4 TYK2 JAK3 IL10RA STAT3 PMC4222248__F7 EGF signaling pathway to stimulate proliferation of conjunctival goblet cells EGF SRC PMC9496100__F3 Ginsenoside and Its Therapeutic Potential for Cognitive Impairment BAD IGF1R IGF1 FGF2 GSK3B PTEN RB1 MTOR BAX PMC7325921__F2 Quantification of intracellular carbon energy metabolism PC PCK1 FBP1 PKLR GIP PMC11617210__F10 ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1A/PPARA pathway: integration of WGCNA, machine learning and experimental validation CXCL10 CXCL8 ADRB2 CCL2 NR1C1 SIRT1 PMC3764486__F2 Expanding roles for CD4+ T cells in immunity to viruses TH CD27 TNLG8A CD40 ICOS PMC4785262__F3 Neutrophil Functions in Periodontal Homeostasis ARHA MYD88 SMURF1 MAL PMC7542236__F1 PI3K/Akt/mTORC1 pathway, Ras/Raf/MEK/ERK pathway, mTORC2 signaling, and the EMT process CSK SRC ARHA SYK EIF4E IRS1 RHEB PMC4380230__F2 Endothelial cell metabolism in normal and diseased vasculature DHFR PARP1 ARHA AGXT2 HMGCR HEL-S-162eP PMC9181642__F8 Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells PDK2 INS PMC3916982__F2 Crosstalk of signaling pathways in breast cancer and the potential clinical therapeutic targets NF1 BAD EGFR MDM2 BCL2 PTEN EIF4E RHEB PMC8517487__F10 Expression of Microtubule-Associated Proteins in Relation to Prognosis and Efficacy of Immunotherapy in Non-Small Cell Lung Cancer BAD CD46 EBP APC PTEN OASL TSC1 ATM CDK2 CYC1 ATR PER2 PER3 PMC8526928__F2 Rhinovirus Immunity and Asthma STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 PMC2677387__F1 mTORC1 activation by nutrients and growth factors TSC2 RICTOR TSC1 PTEN MTOR RHEB MLST8 PMC4324736__F3 Individual involvement of the products of the eight studied genes (shown in red colour) in the (a) RAS/RAF/MEK/MAPK, (b) PI3K/AKT, and (c) GNAQ/11 signalling transduction pathways GNA11 BRAF PTEN HRAS MTOR PMC7247819__F2 Activation and inhibition of the AIM2 and NLRP3 inflammasome in SLE, Ps, AD, and vitiligo NLRP3 TLR7 IL5 AIM2 PLXNB2 PMC5669850__F1 Role of the inflammasome in chronic obstructive pulmonary disease (COPD) TLR5 TLR9 NOD1 RIF1 TRAF6 NOD2 TLR3 TIRAP PMC10530962__F2 Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications SMAD2 SMAD4 PMC6000455__F1 mTOR信号通路mTOR signaling pathway TSC2 EGF TSC1 IGF1 PTEN EIF4E IRS1 RHEB PMC8484528__F5 Integrated Analysis and Finding Reveal Anti–Liver Cancer Targets and Mechanisms of Pachyman (Poria cocos Polysaccharides) EGF MMP9 FGF2 ALB VEGFA BCL2L1 TNF HRAS PTPRC CASP3 CXCR4 SRC STAT3 PMC6701435__F5 KEGG pathway analysis for HepG2 cells depicting the upregulated genes in the TNF signaling pathway after the treatment with TIT3; the altered genes are marked MMP3 MMP14 TRADD LIF TNF FADD MLKL ALPI SELE ITCH SELL PMC6337474__F1 Top left: Wnt binds to the Frizzled receptor (Fz) and the LRP5/6 co-receptor BMP2 MSC PTH PMC9181207__F1 Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis CYP27A1 CH25H GCA CYP46A1 CYP8B1 CYP7B1 BAAT CYP7A1 PMC2782725__F2 Cell cycle and acute kidney injury BAX PMC8607431__F7 Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy BRAF YAP1 SRC PTEN MTOR PMC8237188__F1 JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib EPO TYK2 JAK3 JAK1 IFNG PMC11941543__F2 Influenza virus interaction with autophagy MTOR PMC7493230__F4 Proposed mechanism for the EGFR/c-Met-mTOR/S6K signaling axis in NSCLC TSC2 EGF HGF FOSL1 WEE1 EGFR LRP5 EIF4E RPS6 RHEB PMC6937862__F2 The graphical user interface and output of ZDOG MYB GSK3B MYC BCL2L1 PDPK1 PRKCA TNFSF6 MDM2 CASP9 CDKN1B EIF4E HRAS IRS1 BRCA1 CREB3 RHEB MLST8 RXRA TSC2 YWHAQ TSC1 MTCP1 CDK2 GRB2 BCL2 AKT3 CHUK BAD PHLPP2 PCK1 CSF3 CSF3R PTEN BCL2L11 EIF4EBP1 MTOR RPTOR CCND1 MAGI1 RPS6 EIF4B RBL2 CD19 FOXO3A GYS1 ITGB1 RPS6KB1 NFKB1 PKN3 PIK3CA SYK CRTC2 RAF1 MCL1 SOS1 CSF1 PMC5427079__F6 Reactome pathways displayed in Figure were converted into a functional interaction network using FI network view CTRB2 LMF2 GPC4 LIPC GPC2 CTRC AMN SDC2 MTTP A2M APOF TCN1 APOA2 PMC5427079__F5 Enriched pathway analysis: The entities in the diagram colored purple are hits within positive gene list NOTCH4 STXBP3 STX4A PMC10739988__F2 Advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review) EGFR MTOR STAT3 PMC7709261__F1 Outline of TGFB signaling pathway regulating HCC initiation and progression MMP9 TGFBR1 EGFR MYC CD44 TGFBR2 CD96 THBS1 CDH2 AXL PCNA STAT3 PMC1767116__F3 Mitochondrial death signalling pathways BAD DIABLO PMC7709261__F2 Function of lncRNAs in regulating TGFB signaling pathway to affect HCC tumorigenesis KRT19 TGFBR1 TGFBR2 PMC10657592__F1 Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering EGF SMAD2 GRB2 SMAD4 TRAF6 RAC1 LPA PMC8567041__F4 Integrative multi‐omics approach for mechanism of humidifier disinfectant‐associated lung injury MMP2 SMAD2 PMC8522789__F1 Clinical and Mechanistic Characteristics of Current JAK Inhibitors in IBD IL10 IMPACT IL2 TYK2 IL6 IL-21 JAK1 IL5 PMC8674945__F1 Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation HEL-S-62p PLG VTN HNRNPC CRP SRC PMC4607752__F5 BaP effects on the expression of BaP marker genes and genes involved in the AHR signaling pathway ANXA1 MPO ABHD4 LDB1 GCLC HUNK NFE2L2 NBEA SNAI2 FGFR3 EMILIN2 MYH7 TXN FGFR2 AHR SLC22A7 APP THBS1 CELF2 HSPA1A EN1 STAT3 PMC10725447__F0 Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/Beta-catenin signaling activation APC FAM83F PMC5434467__F1 The structure of IL-35 and the activation of the JAK-STAT signaling pathway STAT1 EBI3 STAT4 PMC5814839__F8 P53 signaling pathway targeted by hsa-mir-34a in liver cancer DKFZp781B1423 EI24 PTEN CCND3 CDK6 SIAH1 PERP SESN3 ATM RRM2 APAF1 MDM2 ZMAT3 CDK4 BAX RPRM CD82 DDB2 CASP3 TSC2 IGF1 BBC3 PIDD1 TP73 ATR CYCS PMC8568984__F4 Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin AQP1 RHAG SLC4A1 CA12 PMC6714137__F11 Schematic representation of inhibitory effect of miR‐539 on EMT and metastasis of PCa SMAD4 DLX1 PMC10173380__F7 Schematic diagram illustrating the mechanisms through which VNN1 in PC cells induces Beta-cell dedifferentiation by inhibiting the AMPK/GAPDH/Sirt1/FoxO1 signaling pathway VNN1 SIRT1 FOXO1 HEL-S-162eP PMC6966464__F2 Four ErbB receptors EGF BAD ERBB3 NRG2 HBEGF NRG1 PTEN MTOR SHC2 ERBB4 BTC ERBB2 GRB2 SRC TGFA PMC2195865__F1 Extrinsic and intrinsic cell death signaling pathways FADD BAX PMC5759086__F3 Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing TH PNMT DBH PMC6379280__F2 Rationale for choosing Arl13b, SMO, and melanin-concentrating hormone receptor 1 (MCHR1) as cilia-targeting moieties ARL13B PTCH1 SHH SMO MCHR1 PMC4082763__F1 Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease RHO IPP PMC8883943__F1 D-Amino Acids as a Biomarker in Schizophrenia DAO ddo DAOA PMC9693569__F1 Polyphenols for Livestock Feed: Sustainable Perspectives for Animal Husbandry? OMG IPP RRH PMC11891048__F2 S-palmitoylation is involved in immune response types PLCG1 ZDHHC4 SQSTM1 FOS APC ZDHHC3 ZDHHC11 ZDHHC12 ZDHHC7 ZDHHC21 ZDHHC19 LCK LYN ZDHHC5 ZDHHC8 SYK PALM FADD LAT STAT3 BAX CD36 PMC7600636__F2 Canonical pathway of STAT3 signaling SOCS3 SRC STAT3 PMC2820477__F2 Scheme of known Wnt pathways APC LRP5 LRP6 ARHA RYK ROR2 RHOB CDC42 PMC3675900__F2 Eicosanoids in Metabolic Syndrome FADS2 ELOVL5 LTB FADS1 CD36 PMC2996902__F1 CoQ10 biosynthesis pathway COQ3 COQ2 COQ6 COQ5 PDSS1 COQ7 PMC12075257__F7 Schematic model showing the role of WED in regulating megakaryocyte differentiation and platelet generation FOS GATA1 PMC2820477__F1 Schematic junctional organization and Beta-catenin signaling in CNS ECs: comparison of brain and retina TSPAN12 PC ESAM ABCB1 PMC3962112__F1 Biosensor-derived promoters upstream of modules B and C to control the expression of fadD and atfA, and the ethanol biosynthetic pathway (adhB and pdc), respectively PDC FADD PMC10620831__F8 PRMTs regulate antiviral innate immunity TBK1 CGAS TRAF6 IRF3 PRMT1 TLR4 PRMT9 PRMT7 PRMT2 PRMT3 PRMT6 MAVS IFI16 PMC5488238__F6 BMP–Notch interaction in intestinal homeostasis and CRC disease subtypes MAML1 BMPR2 GIG8 BMP2 ID1 ID3 BMP4 PMC7075948__F1 Interferon (IFN) signaling enhancement by the inhibition of the Wnt pathway through miR-34 TBK1 GSK3B IRF3 PMC7492298__F6 Granulosa cells undergoing apoptosis CASP3 TNFSF6 CASP9 FSHR BCL2L11 CASP8 FADD BAX PMC7836322__F2 Replication cycle of HCoV DPP4 ACE2 HEL-S-69p PMC9574713__F7 Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy UGCG UGT8 GBA2 PMC6757160__F2 General mechanism of SYK activation and SYK-mediated signaling: a pathway demonstrating the involving of downsignaling associated with SYK activation NLRP3 SYK CFTR PMC6705574__F8 The mechanisms underlying contributions of YAP/TAZ/Beta-catenin to the spinal central sensitization after nerve injury and regulation of dCTB on YAP/TAZ/Beta-catenin and Hippo signaling pathways APC GSK3B LATS1 LPA LATS2 PS1TP5BP1 PMC7018500__F1 Signaling pathways involved in the recognition of HSV STAT1 CGAS TLR9 STAT2 IRF7 IRF9 TRAF3 IRF3 TYK2 MYD88 JAK1 TLR3 PMC11016017__F3 Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling SOX2 SMYD3 EGFR CD44 IRAK4 TNF MTOR COX2 ATM SIRT6 ATR BAX CD24 PMC7607115__F2 Model for TERT promoter mutations, TERT expression and telomerase activation during the pathogenesis of TC BRAF TSHR CDKN2A TERT PMC5720788__F1 Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis INA CP PMC4545213__F4 Mammalian molecular clock and oscillation of mRNA and protein in peripheral tissues CRY1 FBXL3 CRY2 PER2 PER3 PMC8235534__F1 Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update PC PCK1 F2 ACLY PCK2 HEL-S-133P HEL-S-162eP PMC11968292__F3 Keap1-dependent and Keap1-independent regulatory pathways of Nrf2 AHR KEAP1 PMC8035078__F1 LTA synthesis, models for the cross-membrane d-alanine modification process and examples of WTA and complex SCWP synthesis pathways LTA GAL PMC6207586__F6 Mechanism of action of microtitre plate based complement activation assays C9 C7 C6 PMC8397452__F6 Multifaceted Roles of Proline in Cell Behavior LEFTY1 PKDCC ATF4 SMAD2 LEFTY2 FGF8 PRODH PMC3039745__F1 TRAF6 and A20 control K63-linked ubiquitination of Beclin 1 to trigger autophagy TLR4 TRAF6 BCL2 PMC9569951__F1A Roles of Androgens in Humans: Biology, Metabolic Regulation and Health TH SST PMC4292866__F11 Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase COX1 RUNX2 COL10A1 PMC2941735__F2 Targeting Non-Homologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization EGF EGFR PTEN TGFA PMC2938833__F2 Actin-cytoskeleton signaling pathway and the candidate genes involved in colorectal cancer progression in patients with ulcerative colitis CD14 EGF ARHGEF1 F2 ARHGEF12 BAIAP2 GRB2 LBP ABI2 ARHA PMC2938833__F3 Pfn gene neighborhood and its interacting pathway VASP WASF1 PFN3 PFN4 PMC6127659__F1 Long non-coding RNAs affect epithelial-mesenchymal transition in gastric cancer cells HGF YAP1 SMAD2 WDR5 MMP9 GSK3B EZH2 SUZ12 EED PMC4190549__F1 The PI3K/Akt/mTOR pathway BAD CCND1 PTEN MTOR PMC4467582__F7 Proposed schema of the pathways underlying renal protection conferred by xenon (Xe) preconditioning PTEN TNF PMC5362547__F1 Hippo signaling pathway provides novel anti-cancer drug targets LATS1 MOB1A MOBKL1A AXL LATS2 PMC8277576__F5 Steroids on T lymphocytes AIRE FOXP3 PMC9237470__F1 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response SUFU SHH SMO PMC11800603__F2 Innervation in gliomas promotes tumor growth NLGN3 GRB2 SRC MTOR BDNF PMC9237470__F2 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response SUFU PTCH1 SMO PMC10967436__F7 ROS modulation of the Keap1-Nrf2-ARE signaling pathway MAF KEAP1 NQO1 PMC11800603__F3 Several example mechanisms of therapeutic avenues of cancer neuroscience: A Inhibit of ADAM10/NLGN3 can suppress glioma growth by targeting its downstream PI3K-mTOR signaling pathway NGF NLGN3 ADAM10 BDNF PMC8481821__F2 Neu Perspectives, Therapies, and Challenges for Metastatic HER2-Positive Breast Cancer EGF BAD GRB2 HBEGF NRG1 HIF1A MTOR TGFA PMC4613661__F1 Model for KSHV v-cyclin-induced dysregulation of Notch signaling during lymphomagenesis CCND3 NOTCH3 CDK6 HES1 PMC3653035__F1 Beta-Catenin plays two main functions in the cell LEF1 APC LRP5 LRP6 PMC3653035__F2 Wnt ligands induce diverse Wnt pathways LEF1 MAP1B LRP5 LRP6 RYK RHO PMC3516764__F9 Model for the involvement of the RA in neuronal differentiation RARB AJUBA FABP5 SIRT1 PMC2726781__F1 Retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN) VPS35 M6PR APP PIGR VPS29 PMC3314478__F1 Parkinson’s disease: don’t mess with calcium TRPC1 ATF4 MTOR STIM1 PMC10759737__F6 RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding YY1 MTOR SPHK2 RPTOR STAT3 PMC4721539__F1 Dissecting Germ Cell Metabolism through Network Modeling PLB1 CES1 ADFP PNLIP CES3 CYP1A2 LRAT LIPE CYP26B1 LDLR PID1 RETSAT ABCA4 HEL126 PMC7319280__F7 Systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics ATM MDM2 OSM PMC7369811__F7 Scheme of the potential IR-induced EGFR/NFKB–RIP1–Src–STAT3–EMT pathway EGFR SRC STAT3 PMC7232439__F1 Schematic diagram for activation of innate immune responses and interferon (IFN) signaling pathway after influenza A virus (IAV) infection NLRP3 CH25H IRF7 IRF9 IRF3 TYK2 TLR3 MAVS PMC5075576__F2 Complement-dependent cytotoxicity and inflammation HEL-S-62p CD59 C4B_2 PMC6449645__F1 (A1) GPCRs induce GAq dependent c-Src activation at the plasma membrane and tyrosine phosphorylation of NEDD4-2, releasing NEDD4-2 auto-inhibition SRC MAP3K7IP1 NEDD4 PMC4851164__F3 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation EGF IGF1R SNAI1 HGF EGFR GSK3B SNAI2 FOXC2 ZEB2 SRC SHH SMO AXIN2 CHD1L EGR1 c-fgr HEL-S-28 CD44 FUS PAK1 IGF1 TWIST1 SUFU GRB2 CDC42 PMC4743039__F8 Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling ARHA MTOR MAL PMC4491987__F6 Effect of the combination of rapamycin and resveratrol on the PI3K/Akt/mTORC1 signaling pathway TSC2 TSC1 EIF4B IRS1 RHEB PMC4851164__F7 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation SNAI1 SUFU HEL-S-28 GSK3B SHH SMO FUS PMC4398700__F3 Ingenuity® Pathways Analysis reveals a possible network of genes activated in IEC-6 cells upon induction of the ephrin-B pathway PIM1 AHR FOS CAST PTGS2 F3 FBN1 ATF3 JUNB SP1 HES1 PMC3156249__F1 B-Myb, Cancer, Senescence, and MicroRNAs E2F4 CDK2 SKP2 PMC4731824__F8 Novel NFKB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis BTRC TRADD IRAK1 RELA TRAF6 YY1 IRAK4 MYD88 TRAF2 PMC3039968__F2 Regulatory Processes Linked to PL Metabolism COX2 COX1 HEL-S-5 PMC11794924__F3 Molecular mechanisms of granulomatous inflammation for sarcoidosis; Antigen-presenting cells, like macrophages and dendritic cells, initiate phagocytosis of antigens CCR5 CCR6 MTOR FOXP3 STAT1 CXCR3 IL16 TBX21 IL33 CCL20 TYK2 JAK1 STAT3 PMC8210588__F5 Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives MVD MVK IPP PMC9661764__F5 ERAlpha-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer GCLC ERG CD44 ABCG2 ABCC2 ABCB1 PMC9197233__F5 Mechanical Strain Induces Transcriptomic Reprogramming of Saphenous Vein Progenitors MAP2 MAP2K4 IRF7 NODAL PITX2 SMAD2 HOXC9 MAP2K1 NR1i1 TLX2 AMH ZNF423 GRB2 BCL2 GSC RNF111 SMAD1 DKFZp781O1323 CDC42 PMC2854141__F9 Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease EGF AGTR1 CSF3 EGFR MYC NEF3 CREB1 NEFH TTN BMP4 NF1 BCR SRC ETS2 IL4 SP1 FCAR JUN HEL-S-133P EGR1 NDUFV2 ARHA CEBPA TNF GAST FOXO1 PRL PLCB1 HEL-S-69p LEP ERBB2 BCL2 RNPC3 MCL1 CSF1 TGFB1 MYOD1 NEFL STAT3 PMC7892446__F2 Mechanisms by which SARS-CoV-2 promotes muscle wasting and sarcopenia IGF1R SOCS3 SMAD2 MTOR ACE2 PMC6966687__F3 Networks presenting the functional protein-protein interactions of the (A) 97 down- and (C) 67 upregulated proteins related to the GO term “protein phosphorylation” (GO:0006468) ABL2 SNRK ALK TEC MTOR AURKA LATS2 RICTOR LIPE MUSK SMO LTK FASTK MASTL PMC7352245__F3 Canonical and alternative NFKB signaling pathways RELB TRAF3 CD79B CD79A BIRC2 BTK CARD11 BCL10 BCR NFKB1 RELA BIRC3 LYN CD40 SYK TRAF2 LTBR PMC7759744__F1 Mitochondrial dynamics and bioenergetics in inflammatory astrocytes and neurological disorders MFN2 PDK2 CDK5 OPA1 PMC9495339__F3 Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches MAFF KEAP1 MAFK GSK3B RBX1 PRX NQO1 MAFG PMC7017485__F4 Ingenuity Pathway Analysis showing the plasma membrane and extracellular proteins directly related to YAP1 IGF1R AMOT PIEZO1 EGFR DMD PRNP DAG1 ERBB4 NF2 USP9X APP THBS1 DCC PARD3 CCDC85C SV2B PRRG2 NPPA PIEZO2 MPDZ MPP7 AREG NEGR1 BMP2 IGF2 IGFBP7 SCNN1D LRP6 TRIP6 EDN1 PATJ VCAM1 DEFA6 ZYX PTCH1 HEL-S-52 MSLN CTNNA2 CD36 AGRN PMC7698885__F6 PNPLA3 I148M promotes activation of HH signaling and its downstream target Yap PNPLA3 HEL-S-30 AREG PFKL FOXF1 PMC8750789__F2 AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders AUTS2 PCGF5 ELMO2 MDGA1 RAC1 CDC42 ST3GAL5 CACNA1C PMC10887023__F2 Gene interaction network of dyslexia and stress-associated genes P2RY1 MIB1 RP1L1 PCNT TFIP11 CMIP AKAP9 GPNMB TSC22D3 NR3C1 FKBP5 NR3C2 MRPL19 AKR1B1 KIAA0319 KIAA0319L S100B DYX1C1 TSC22D2 DCDC2 TMEM130 MRGBP C21orf66 MANSC4 CNTN2 PRMT2 MANSC1 ROBO1 PMC3696556__F4 CD4+ follicular helper T cell infiltration predicts breast cancer survival PLCG1 FOS CD6 CSK BTLA CTLA4 PAG1 CBL BATF FYN BCL10 CD27 LIME1 LCK DUSP16 SIT1 PTPN4 REL JUN LAT NFKBIE AKT3 PMC4529918__F1 An illustration representing microRNAs (miRNAs) and their targets involved in EGFR signaling pathway in lung cancer and anti-EGFR therapy BRAF EGFR MYC ERF PTEN MTOR PMC3696556__F5 CD4+ follicular helper T cell infiltration predicts breast cancer survival HEL-S-62p CD6 PAG1 BATF TNFRSF9 ITK FYN BCL10 CAMK4 CRTAM GRAP JUN ICOS CSK FOS BTLA CD200 CTLA4 CARD11 DUSP5 CD27 LCK SIT1 TRAT1 ZAP70 PTPN4 IL2RA CD80 REL LAT HEL-S-81p STIM1 NFKBIE AKT3 PDCD1 PMC7290974__F4 Altering host gene expression by disrupting transcriptional regulators PML TRAF6 MYD88 PMC5179328__F3 TLR signaling pathway and ENU-induced mutations that impair TLR-dependent TNF or type I IFN secretion TBK1 TLR9 DTNBP1 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 TLR7 TLR4 IRF-1 CD14 TLR5 HPS5 IRF7 CSK IRF9 UNC93B1 IRF3 TNF TLR1 MAP3K7IP1 TLR3 LTA EIF2AK4 SLC15A4 SYK RHBDF2 HCFC2 MLKL TIRAP CD36 PMC11758815__F8 Iron signaling BMP6 HAMP FES CD44 PCBP1 MCOLN1 SMAD1 TF DKFZp781O1323 PMC7290974__F1 Toll-like receptors (TLR) and nucleotide-binding domain and leucine-rich repeat (NLR) receptor signaling in response to L NOD1 IRF7 TRAF6 IRF3 IFNAR2 MYD88 RIPK2 IFNAR1 NOD2 TLR3 PMC11758815__F9 Copper signaling MT3 EGFR CD44 MTOR SLC25A3 HEL-S-67p ATP7B ATP7A ATOX1 HEL-S-44 SLC46A3 DLAT PDZD11 CCS PMC3406594__F8 Schematic model showing role of AMPKA1 as an upstream kinase of TAK1 in TLR4-mediated signaling pathway TLR4 IRAK1 TRAF6 MYD88 TNF TAB3 MAL PMC7900430__F2 Mechanism of the inhibitory role of Wnt/Beta-catenin pathway in preadipocytes during adipogenesis APC GSK3B LRP5 LRP6 PMC8307089__F1 Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer? TBK1 HMGB1 FER CD80 ATR IFNG PMC7829553__F1 Currently known CoA-dependent enzymatic reactions and transporters in human peroxisomes GNPAT ABCD3 NUDT7 NUDT19 DBP LBP CRAT CROT BAAT ABCD2 ACOX1 PXMP2 PMC7829553__F2 Currently known NAD+/NADH- and NADP+/NADPH-dependent peroxisomal enzymatic reactions, transport of NAD+/NADH, NADP+/NADPH, NMNH+, AMP, and 2′,5′-ADP, and role of shuttle systems HEL-S-26 NUDT12 PEX5 DBP LBP DECR2 PEX13 HEL-S-32 PEX14 PXMP2 GPD1 HEL-S-281 PMC7829553__F3 Currently known FAD, PLP, ThPP, FMN, and heme-dependent enzymatic reactions in the peroxisomes and transport of FAD, PLP, ThPP, heme, FMN and AMP NUDT12 PEX7 HAO1 PEX5 PEX13 PEX14 PMC8312441__F7 Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma PCDH15 CDH23 E2F4 CDH24 CDH26 PCDHGA12 PCDHJ CDHR1 PCDHB4 CDH16 TFDP2 PCDHB7 RDX TFDP1 PKMYT1 CCNE1 WEE1 E2F2 NF2 CCNB1 CDC2 RBL2 RBL1 CCNE2 CKS2 CDKN1B DCHS1 CKS1B CDHR2 CDKN1A CDK2 CCNB2 CDH17 PMC2744356__F1 Toll-like receptors in skin infectious and inflammatory diseases TBK1 TLR8 TLR5 TLR7 TLR4 TLR9 IRAK1 TRAF6 IRF3 MYD88 TLR3 PMC5992788__F1 CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease APP GATC PMC5178148__F2 Hypothetical model depicting a potential role of SMAD3 activation in GCT development FOXO3A F3 TGFBR1 TRIB3 PTEN TGFBR3 FOXL2 FOXO1 GATA4 PMC7869020__F1 Purine salvage and de novo purine biosynthesis (DNPB) PFAS ADSL PAICS APRT PMC4310752__F1 Therapeutic targeting of cancers with loss of PTEN function RAD51 PTEN PMC2519122__F1 Role of mTOR in anticancer drug resistance NF1 TSC1 GRB2 PTEN EIF4E IRS1 RHEB PMC4037353__F1 MicroRNA regulation of the germinal center response TH PHLPP2 GC CCR7 PTEN RORA NCOR2 ICOS BCL6 PMC9104602__F5 ZIKV infection downregulates host mRNA expression in the placenta, including genes associated with cellular function and development MHC2TA RAB38 EPO TNFAIP6 SOX1 TNFSF13 MTCL3 ONECUT1 OLIG2 CELSR2 BRS3 UNC93A MMP3 SSMEM1 ADGRB2 ADGRB1 LIN7A NRIP2 KCNN2 LY6G6D ZBTB7C MPP3 TBR1 SKOR1 SYT9 SYT17 FOXR2 DNAAF19 LYRM7 LHX5 TNFSF8 SERPINI1 KCNK4 NOBOX POU2AF1 TNF IRS1 EDN1 SLC6A3 RASGRF1 GRM8 BDNF CIDEA INA CXCL1 ACSS3 AQP4 SIM2 RARB SV2C THBS1 NEUROD1 POU5F1 ARG1 MGP GIPR NTRK1 HEL-S-92n CD79B SYT1 TDO2 NMU PDGFC CNTN2 BANK1 MAPK8IP1 PLA2G2A OCA2 H4C9 PMC3864542__F1A What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-kinase Pathway PTEN EIF4E IRS1 PMC8557339__F4 Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis C4B_2 HEL2 SFN CSF3 HEL-S-1 HAVCR2 CA3 C4A MRC1 ISG15 CD209 YWHAG UFC1 S100A4 PGAM1 FAM3B LYZ CD300C HEL-S-34 GFAP SLAMF7 GRN HEL-S-69p YWHAQ HEL-S-66 HEL-S-93 PMC8971730__AF1 CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway SRC CCL18 ARF6 PMC3281634__F1 Simplified diagram of the unfolded protein response ATF4 EIF2A XBP1 PMC5288713__F6 Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage IL16 NLRC4 NOS2 PMC7869020__F5 Regulation of de novo Purine Biosynthesis and Purinosome Formation PRKCE PFAS ATM ADSL PAICS HEL-S-70p ATR AURKA AURKB PMC9479340__F1 Tumor accomplice: T cell exhaustion induced by chronic inflammation EGF HGF PMC4497368__F1 The signaling pathway involved in EPO-induced neuroprotection EPOR EPO MMP9 RHO STAT3 BAX PMC4524753__F2 Diagrammatic sketch shows the hypothetical mechanism of HOTAIR in digestive tract cancers ME3 PMC11821962__F4 WWP1-involved signaling pathways and regulatory mechanisms ERBB4 RNF11 SMAD2 KLF14 KLF5 MYC PTEN WWP1 NDFIP1 BAP1 PMC11821962__F5 WWP1 in different types of human cancers SMAD2 KLF14 MMP9 KLF5 VEPH1 MYC PTEN LATS1 WWP1 MMP21 MTOR LATS2 CDK6 MMP2 NDFIP1 TCF4 STAT3 BAP1 PMC9630603__F4 Intersection of stem cell biology and engineering towards next generation in vitro models of human fibrosis SMAD2 MSC SMAD4 PMC9486394__F1 Regulation and coordination of the different DNA damage responses in Drosophila ATM CDC2 ATR PMC9486394__F2 Regulation and coordination of the different DNA damage responses in Drosophila OGA ATM CDC2 ATR PMC2901146__F2 Taxol biosynthetic pathway C9 IPP PMC9329401__F7 High protein diet in the induction of sIgA response TLR4 CCL28 PIGR PMC8031259__F2 Insulin signalling pathway and Insulin resistance in COVID-19 and Diabetes infection.Adapted from Jung & Choi (2014), Finucane and Davenport (2020), Rajpal et al TBP IRS1 PMC5130286__F3 Working model IRAK1 VEGFA TRAF6 RPE PMC5923440__F1 MAMP/PAMP sensing pathways in the intestine TBK1 CGAS TANK IRF7 IRAK1 NLRX1 TRAF3 TRAF6 IRF3 MYD88 NOD2 IL16 NOD1 SIGIRR CARD8 MAVS PMC7583738__F1 PTEN in the PI3K/Akt signaling pathway GSK3B CCND1 PTEN EIF4B PMC9386306__F10 Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression TWIST1 ZEB2 PMC5384626__F1 Metabolic pathway of retinoic acid CYP26A1 CYP26B1 CYP26C1 ALDH1A3 HEL-S-53e RDH10 DHRS3 ALDH1A2 PMC3303474__F3 Bibliosphere network of ubiquinol-sensitive genes regulated in liver tissues of C57BL6J mice ABCA1 SP1 TF GPAM PMC7145850__F3 Quantitative results of sphingolipids and enzymes by LC-MRM-MS SPHK2 ASAH2 SGMS1 UGCG ACER1 CERS3 LASS1 SMPD1 SPHK1 DEGS1 CERK CERS2 SGPP2 PMC7572682__F2 Lysosome and nucleus interaction in signaling and transcription TFEB FOXO3A ZKSCAN3 CRTC2 NR1C1 PMC4903173__F1 Foiling IDOL to help control cholesterol PCSK9 USP2 LDLR HMGCR PMC6798117__F9 Model depicting the effects of ZIKV infection on cell cycle progression in hNPCs ATM ATR PMC8112476__F1 Targeting inflammation in atherosclerosis — from experimental insights to the clinic NLRP3 TFPI CCL7 IL1B PMC6729001__F7 Schematic model of METTL3 in regulating CRC METTL3 PMC2783472__F1 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy ATM MDM2 RAD50 H2AX MRE11A BRCA1 BAX PMC2783472__F2 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy PML ATM CDK2 CDC2 ATR BRCA1 BAX PMC6895606__F1 CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases LIAS PPCS PPCDC COASY MECR PMC6714168__F2 The role and proposed mechanism of Wnt5a in psoriatic arthritis ROR2 RHO PMC10851565__F3 Autophagy’s dual-edge effect on NF-KB and PI resistance ULK1 ATG12 TRADD IRAK1 RELB IRAK4 MYD88 ATM VCAM1 CYLD SYK REL OTULIN TAB3 PMC12023901__F8 ERS-mediated suppression of ERA expression ATF4 XBP1 PMC8268178__F1 Connecting Cholesterol Efflux Factors to Lung Cancer Biology and Therapeutics NPC1 STARD3 PMC5110879__F1 MicroRNAs biogenesis and function AGO2 DGCR8 DROSHA PMC9329261__F2 Elevated CD4+ T Cell Glucose Metabolism in HIV+ Women with Diabetes Mellitus HEL-S-26 HK3 PDK2 PDHA1 MDH1B PMC6418414__F1 The wild-type CARD9 protein consists of an N-terminal caspase activation and recruitment domain (CARD) followed by a coiled-coil domain and a C-terminal tail CARD9 BCL10 RELB SYK TRIM62 COIL TNF PMC7015808__F1 Steroidogenic pathway with oxysterols followed in this study.Abbreviations: CHEH – cholesterol epoxide hydrolase, CH25H – cholesterol 25-hydroxylase, CYP – cytochrome P450, DHCR7 – dehydrocholesterol reductase, ROS – reactive oxygen species CYP27A1 CH25H DHCR7 CYP7A1 PMC3147800__F9 Model showing the cooperative function of LMO7 and Rho in the activation of MRTFs RHO LPA LMO7 PMC8797967__F8 Knockdown of ferritin heavy chain (FTH) inhibits the migration of prostate cancer through reducing S100A4, S100A2, and S100P expression S100P S100A2 S100A4 ELL PMC4589691__F6 Regulatory relationships of a KEGG gene set for the human T cell receptor signaling pathway in RegNetwork IL10 CD47 CHUK FOS GSK3B NRAS TNF HRAS IFNG NFKBIA MAPK13 PAK1 FYN BCL10 RELA LCK CDK4 IL4 CSF2 JUN TF PMC11853510__F2 Mechanisms of bioactive materials and cytokines in regulating inflammation and maintaining pulp equilibrium through various signaling pathways involving the nucleus [70,71,72,73,74,75,76,77,78] TH TRADD APC IL4 PMC9221615__F9 Endothelial Dysfunction in Acute Hepatic Porphyrias FECH UROD UROS HMBS CPOX PMC3262938__F2 N-glycan biosynthetic pathways in eukaryotes and glycoengineering ALG3 MNS1 PMC10970066__F1 Major components and auxiliary factors of the Notch signaling pathway (modified from ) EGF EP300 MYC CCND3 FBXW7 KDM5A PMC7927147__F1 Development of opto-BMP system BMPR2 SMAD4 SMAD1 DKFZp781O1323 PMC9172199__F3 Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment TSG101 CD9 CD63 ARF6 CD81 PMC3501016__F1 Finding a New Regulator of the Blood Coagulation Cascade♦ PAK1 TFPI TF PMC10647767__F1 Developments in Genetics: Better Management of Ovarian Cancer Patients CHEK2 FANCD2 ATM BRCA2 RAD51 BRCA1 PMC9324059__F5 Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2 IL10 REN EGFR VEGFA MTOR IRS1 PMC7875638__F4 Network with 11 herbs, 165 active ingredients, 110 intersection targets, and 8 signaling pathways MOS HIRA MMP2 PMC4496101__F1 The extrinsic and intrinsic apoptotic pathway HTRA2 FADD BAX PMC4148637__F1 Relationship between PI3-K–Akt–mTOR signaling and autophagy in muscular dystrophy TSC2 ATG12 FOXO3A BNIP3 RHEB PMC4697333__F5 Reconstruction of TNFAsignaling pathway (target instance) MAPK9 GLB1 DERA SMAD2 SOST MAPK3 MAPK14 EZR CREB1 NFKBIZ RB1 RPSA USP11 RASA3 DOK1 CRYAA PSMD13 PSMD7 MCC IRF-1 CASP8 MAPKAPK2 MAP3K1 SOS2 ERBB3 MAP2K5 IPO13 TNF CASP10 RPL18A FBXW11 DIABLO IRS1 DPF2 SMARCC2 TXLNA NUPR2 NSMAF TSC1 COPB2 TNFRSF1B PRKCB G3BP2 NFKB2 COPS4 AIMP2 CSRNP2 POLR2L NKIRAS1 TNFRSF1A KPNA2 NKIRAS2 BCL2 MYBPC3 PPP2CA LITAF RASA4 SPHK1 POLR2C PSMD6 RNF25 TBKBP1 AK1 TBK1 MUC1 TNIP2 RNF31 HEL-S-101 COPA LRPPRC COPS8 YWHAG RUVBL2 FBL USP2 POLR2K MTIF2 DDX3X CDC37 RPL4 RPS11 RAC1 TRAIP MAP3K7IP1 EED IKBKB CREBBP NEK2 SYK TRIM28 SMARCD1 PYGL CYBA PRKCZ MOAP1 MADD HEL-S-1 HSPA2 TRAF3 TRAF6 BCL2L1 PSMB3 TXN SMARCC1 PRKCA ING4 C9 SMARCA4 HSPA4 ARCN1 ARHGEF1 FOS PSMA2 GADD45A MCM7 CYBB RXRA MCM3 RPS13 RASSF1 MCM2 TNFRSF8 TGIF1 CKAP2 PSMD2 NCF1 MYLK NFKBIE TAB3 ITCH PML PIG59 IKBKE PRKCE IKBKG TANK BTRC HEL2 MAP2K4 TRADD TICAM2 EGFR RELB CASP2 SENP2 MTOR PPM1B TICAM1 ROMO1 PAPOLA GREM1 PRC1 NOD1 MYBBP1A PTPN11 ARF3 JUN BAX IRS4 SENP1 SKP1 RIPK3 PPP2R1B FAF1 SMARCE1 ALPL BIRC2 RPS6KB1 MAP2K1 COPE TRIM32 COPS5 RELA PIAS1 TXNIP CRADD REL HEL-S-93 FADD PEG3 PMC10647767__F4 Developments in Genetics: Better Management of Ovarian Cancer Patients APC RHO PMC4697333__F6 Cross-talks between TGFBsignaling pathway and TNFAsignaling pathway (target instance) FOXO4 RNF11 FLNA SMAD2 SENP6 GSK3B MAPK14 SMAD4 CREB1 NFKBIZ SOX18 E2F3 MAF PSMD13 FNTA ANAPC11 CNOT4 ITGB3 CDC23 PMF1 SOS2 MYCBP2 YAP1 ERBB3 NUP214 PPIF TSC1 POLR2L RPS6KB2 TNFRSF1A HEL-S-276 STK11 BCL2 NR1C2 LITAF TRIM27 MUC1 ACVRL1 ADAM15 PGR OTUD7B CDKN2C EIF2B1 CTCF EIF2B2 NME2 TFDP2 MAP2K3 EWSR1 XPO5 RARB RPS27A COPS8 CNOT3 NEUROD1 PTTG1 RBL2 SNX1 CCNK RUNX1 USP2 HECW2 NLRP12 VHL TNFRSF19 RPS11 TRAIP SMURF1 XPO4 FOXA2 UBE2C LEF1 ERBB2 SMG1 UPF3B SMG6 PSMB10 HHEX HEL-S-1 HSPA2 TRAF6 POLR2F POLR2H MAGOH EIF3E SMARCA4 ZFP36 SRC JUNB RNF111 PSMB9 MSH4 RUNX3 ARHGEF1 TAF10 RAB6B CRK TNFRSF18 GLG1 CKAP2 SNX4 MEF2C FOXH1 RB1CC1 VPS33A TANK VPS18 TEAD4 VPS36 CITED2 GREM1 PRC1 ATM NKX2-5 NCOA1 SOX2 PARP1 TNPO1 SMARCE1 PSMD3 EIF3F DCP2 PEG3 TCF4 TRAF4 CAMK2A FANCD2 ATF2 MYC RPSA FBXW7 CCNE1 BCLAF1 KHSRP ZEB2 HGS SKI IRF2BP1 IRF7 BAK1 SNX6 IPO13 CASP10 NSMAF COPB2 COPS4 CSRNP2 NKIRAS1 SMURF2 MYBPC3 OLIG1 RNF25 DCAF6 TGFB1 BCAP29 PROK1 ANK2 EID2 CITED1 KIF1B COPZ2 VPS16 EXOSC8 BAG4 ROCK1 XPO7 KTN1 HEL-S-101 CNDP1 COPA FKBP3 MED31 CNOT1 DYNLRB2 SGA56M SIK1 EDF1 POLR3D DKFZp686L0365 EIF3J HERC1 CCNE2 ANAPC2 MAP3K7IP1 CREBBP CCNB2 SYK TRIM24 SHC1 DYRK2 TRIM37 ANAPC10 SPARC CYBA E2F4 MADD MAP2K6 MED15 PRKCA ING4 SND1 STRAP TGFBR3 RPE SAMD3 ARCN1 HOXA9 ATF3 ENG MCM7 CYBB DIS3 BRCA1 EDC3 PAN2 MCM3 MCM6 PAN3 BRCA2 TP73 KLF4 PSMD2 TNFAIP3 TGIF2 HEL2 TICAM2 RELB KLF10 CASP2 SENP2 MTOR HOXA11 DPP3 PAPOLA NOD1 E2F2 SNX2 ARF3 PITX2 SENP1 SMAD6 CIDEB CASP3 HEL-S-102 COPE JUND JAK1 CRADD REL HEL-S-93 PMC10647767__F5 Developments in Genetics: Better Management of Ovarian Cancer Patients MMP2 MMP9 CCND1 HEL-S-53e CDH2 STAT3 PMC4697333__F3 Reconstruction of Notch signaling pathway (target instance) PIK3R1 BLOC1S1 MAGEA1 MXD1 HES6 PRKCZ MIB1 CNTN1 ASCL1 MAPK3 GSK3B RING1 HES1 MXD4 MNT MDM2 NOTCH1 SRC SNW1 HDAC2 MAPK1 SIN3A FURIN NOTCH2 RUNX3 TCF3 PRKCQ PSEN2 RNF2 CHAC1 BCOR HEY2 YY1 ADAM10 ITCH FHL1 NUMB CHUK JAG2 LFNG DLL3 WWP1 CCNC ADAM17 ARRDC1 EPN1 SYNJ2BP RYBP CAMK4 DLL4 MAML2 APP SPEN MFAP2 JUN SAP30 NCOR2 MAML1 RBPJ DTX1 WDR12 DTX2 HDAC1 LEF1 EP300 ASB2 PSEN1 LCK RELA SMAD1 SKP2 PIK3R2 STAT3 PMC5250669__F7 UPR activation in the spinal cord from an X-ALD mouse model ATF4 EIF2A EDEM2 XBP1 PMC10647767__F6 Developments in Genetics: Better Management of Ovarian Cancer Patients HGF MTOR STAT3 PMC4123468__F7 Reactive Oxygen and Nitrogen Species in Steatotic Hepatocytes: A Molecular Perspective on the Pathophysiology of Ischemia-Reperfusion Injury in the Fatty Liver TRADD TRAF2 FADD BAX PMC4697333__F4 Reconstruction of TGFBsignaling pathway (target instance) FOXO4 ATF2 SMAD2 MAPK3 MYC GSK3B MAPK14 SMAD4 RB1 ONECUT1 CCNE1 MAF NR1i1 KHSRP HGS SPTBN1 FOXG1 MAPK1 SP1 SKI FNTA IRF2BP1 ANAPC7 CNOT4 ITGB3 YAP1 NUP214 CDKN1A SMURF2 STK11 OLIG1 PPP2CA SUMO1 EID2 CITED1 ACVRL1 ROCK1 CDKN2D CTCF PROX1 MAP2K3 CNOT1 DYNLRB2 EWSR1 SIK1 FKBP1A DKFZp686L0365 HERC1 SNIP1 VPS39 MEN1 UBE2I STK11IP CNOT3 PJA1 ZFYVE16 NEUROD1 PARD6A AXIN2 RBL2 RBL1 SNX1 RUNX1 ANAPC2 ARHA SMURF1 HDAC1 XPO4 IKBKB CREBBP LEF1 EP300 CCNB2 SMG1 SHC1 ANAPC10 SPARC TRAF6 STAMBPL1 MAGOH MAP2K6 RANBP2 MED15 PIAS2 TAF7 CDC27 SNW1 SRC JUNB PRKAR1B STRAP ANAPC1 RUNX3 FOS ATF3 ENG CRK BRCA1 AURKB EDC3 PAN2 PAN3 EGR2 GRB2 TP73 TGIF1 SNX4 MEF2C FOXH1 ITCH PML BTRC KLF10 WWP1 MTOR FZR1 CCND1 NCOA1 JUN SKIL SKP1 PPP2R1B ITGB1 DVL1 NUP153 MAP2K1 NFKB1 COPS5 PIAS1 JUND RAF1 FANCL SOS1 PXN TCF4 PIK3R2 PMC7458397__F6 p85 roles (p110 dependent and independent) in the insulin response IGF1 GSK3B PTEN IRS1 CDC42 PMC10647767__F8 Developments in Genetics: Better Management of Ovarian Cancer Patients EGF MTOR STAT3 PMC1774279__F1 Two major intracellular pathways cause apoptosis APAF1 BCL2 PMC9203687__F1 ILC2s in Solid Tumors: Facilitate or Inhibit? CCL5 CXCL2 PMC8495393__F8 FGF7-induced E11 facilitates cell-cell communication through connexin43 GJA1 GRB2 PDPN CDC42 FGF7 PMC6350546__F2 Targets and the simplified downstream effects of their autoantibodies encountered during dermatomyositis MAVS PMC6902895__F2 The biosynthetic pathway for argyrin production in Cystobacter sp ARG2 ARG1 CP PMC5913620__F2 Regulation of Beta-cell autophagy ULK1 ATF4 EIF2A RAG1 ULK2 DKFZp686F0183 IL1B RAG2 SIRT1 IFNG PMC9570087__F1 Protein Acetylation Going Viral: Implications in Antiviral Immunity and Viral Infection KAT5 CGAS HDAC3 STAT2 IRF7 IRF9 OTC IRF3 IFNAR2 OTUD3 IFNAR1 STAT1 ISG15 TYK2 JAK1 SIRT1 IFI16 PMC4608686__F6 Equivalent Gene Expression Profiles between Glatopa™ and Copaxone® CCR3 S100A10 CXCL10 APC CCR4 MYD88 TNF IL12B IFNG CXCR3 IL18 IL27 IL2RG STAT4 IL2RA CR2 HLA-DMB IL18RAP GATA3 IL18R1 PMC5868363__F11 Possible cellular mechanisms involved in calycopterin-induced apoptosis in HepG2 cells APAF1 BCL2 BAX PMC7396666__F2 Mammalian UPR ATF4 EIF2A XBP1 PMC3742180__F8 Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles CD14 TLR4 LBP PMC5843858__F4 Diagram showing the possible mechanism involved in the difference between the angiotensin-converting enzyme (ACE) I/D polymorphisms affecting the generation of kinin peptide agonists for B2R and B1R in the downstream variation signaling effects CPM MTOR IRS1 PMC4446516__F1 Complement activation pathways and their regulators HEL-S-62p CD59 C9 MASP1 C7 C6 MASP2 CR2 C4A CR1 PMC4442886__F1 MTOR pathway and its interactions with other important pathways and cellular process relevant to cancer TSC2 TSC1 CDK2 CXCR4 EGFR VHL PTEN MTOR PMC4714670__F4 Cooperation between RasV12 and oncogenic niche cells (ONCs) SCRIB TNF PMC3342401__F7 Summary diagram of the proposed ADM signaling pathway in retina RAMP3 ADM RAMP2 PMC5563468__F5 Regulation of the ROCK/MRTF/SRF pathway in fibroblasts ARHA LPA PMC6941795__F2 Metabolic adaptation and maladaptation in adipose tissue PRDM16 UCP1 ATF2 MCU CIDEA RYR2 CD36 PMC11048169__F1 Main signaling pathways within cancer cells MAP3K1 MAP2 MAP2K4 FOS EGFR ERBB3 MYC PTEN INPP4B FOXO1 CDK6 TSC2 ERBB4 ATM MDM2 GRB2 BCL2 CDK4 MCL1 ATR JUN BAX PMC11048169__F3 Information exchange and signal transmission between cells within the tumor microenvironment NOTCH2 NOTCH4 CCR2 IL6 CCL2 TNF NOTCH3 XBP1 IFNG ATF4 ARG2 EIF2A ZAP70 NOTCH1 JAK1 IL4 TRAF2 ASS1 LAT PMC3113807__F5 The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans PCM1 SGK1 PMC3613937__F1 Desmoglein-1, differentiation, and disease EGF DSG1 GRB2 SHOC2 DSC1 ERBIN LORICRIN PMC8353812__F10 Characterization and comparative analysis of transcriptional profiles of porcine colostrum and mature milk at different parities MYB IFNA1 ITGB3 NGF ITGA2B CSF3 BCL2L11 FGFR2 FGF9 PRKCA LAMA1 TNC ITGB4 LAMB1 THBS2 NGFR THBS3 KITLG JAK3 COL9A1 PIK3R2 COL4A5 CREB5 PMC10301361__F4 Involvement of the cytoskeleton in the immune response to viral infections TBK1 IRF3 MAVS PMC9666114__F1 MP0274, a Novel DARPin Therapeutic Targeting Human EGFR2 Signaling in Breast Cancer After Prior Trastuzumab and Pertuzumab BAD FOXO3A MTOR PMC2268956__F3 The major pathways leading to apoptosis APAF1 HTRA2 BAX HEL-S-162eP PMC4340657__F1 Modes of cell death NLRP3 FADD MLKL PMC9166799__F5 Secreted ARSs function in cancer CXCR1 CDH6 IL8RB YARS GARS1 KARS1 TARS1 PMC3977891__F2 Interplay between Wnt signaling and other anti-ageing pathways APC GSK3B MTOR SIRT1 CAMKK2 PMC7649144__F1 DHEA is synthesized from pregnenolone through the Δ5pathway (red arrows) thanks the activity of the enzyme CYP17A1 STS CYP11A1 HSD3B2 PMC5141431__F4 Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism NAMPT HEL-S-90n NNMT NRK PMC9208818__F3 Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment EGF CMTM6 EGFR IL33 THBS1 COL10A1 PMC3189824__F2 Schematic model for the activation of NFKB signaling pathways PTS RELB CD40 REL LTBR PMC7877337__F3 Virulence factors and related effects in P RAC1 IL1B PMC7471374__F2 Upstream and downstream pathways of CARD9 CARD9 TLR4 BCL10 IRAK1 TRAF6 SYK IRAK4 MYD88 TRAF2 PMC4549066__F1 Activation signals for effector and regulatory T-cell division and proliferation PIM2 IL2 JAK3 PTEN MTOR FOXP3 PMC8146599__F3 Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process IL10 ANGPTL4 GDF15 IL6 PMC7973041__F6 m6A methylation plays a critical role in adaptive immunity YTHDF2 YTHDF1 METTL3 VHL JAK1 ICOS PMC7399146__F3 Autophageal mechanism and stages ULK1 ATG12 MTOR DKFZp686F0183 PMC7399146__F4 Physical exercise actions against aging brain and the apoptotic process NGF APAF1 BDNF FADD BAX PMC9604507__F1 Reversible Platelet Integrin AIIbB3 Activation and Thrombus Instability BTK VASP GC VWF SYK PMC7565641__F5 Innate immune signaling pathways modulating BV transgene expression TBK1 CGAS IRF7 IRF3 MAVS PMC6896028__F1 Nrf2, through its targeted genes, has an anti-carcinogenic role in the case of normal cells and a pro-carcinogenic effect in the case of transformed malignant cells CDCA4 PTGR1 GCLM KRT16 ABCF2 KEAP1 GCLC MMP9 VEGFA CXCL8 ARHA HEL-S-22 COX2 CYP3A4 PSAT1 ATF4 HEL-S-44 HEL-S-51e ABCG2 HEL107 SDHB PMC5515859__F8 Proposed metabolic pathway of F18 in vitro HEL-S-25 CYP3A4 FMO5 PMC5651170__F2 Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications APC LCK ZAP70 PTPN22 PMC6896028__F2 The Nrf2 pathway is regulated at multiple levels by different microRNAs KEAP1 RBX1 PMC7973041__F3 m6A modification participates in innate immunity via regulating the recognitions of unmodified transcribed RNA (tRNA), invading pathogens, exogenous RNAs, and aberrant endogenous double-stranded RNA (dsRNA) RNASEL TLR7 EIF2A TLR3 MAVS PMC7129915__F1 Summary of antiviral signaling pathways in chickens TLR7 TLR4 IRF7 IRF9 IFNAR2 IFNAR1 TLR3 MAVS TIRAP PMC9478308__F6 Research into the mechanism of intervention of SanQi in endometriosis based on network pharmacology and molecular docking technology BAD CD37 MEI1 MYC PTEN RAC1 BRCA1 RHEB TSC2 BCR GRB2 SYK GAL RBL2 CD19 PMC9627214__F2 Necroptosis: A new target for prevention of osteoporosis RIPK1 TRADD RIPK3 TNF TRAF2 IL1B FADD MLKL PMC8263639__F6 Tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy TSC2 RICTOR BAD TSC1 GSK3B GRB2 BCL2 PTEN MCL1 RHEB PMC7471374__F3 Maturation of DCs and IL-1A/B mediated by CARD9 NLRP3 BCL10 SYK IL1R1 PMC5962685__F8 ALA metabolic pathway of cucumber under NaCl stress WAS POR PMC5002062__F1 ClC-Kb/2 expression and function in the distal nephron SLC4A11 WNK1 WNK4 PMC4580658__F1 Schematic diagram showing select signaling pathways in melanoma MYC GRB2 CDK4 PTEN PMC7237829__F1 Endoplasmic Reticulum Stress Signaling in Cancer Cells ATF4 EIF2A RTCB PMC8258675__F1 Mechanisms associated with the depigmentation of brown eggshells: a review ABCB6 FECH UROD SLC25A5 UROS CPOX ABCG2 PMC7576986__F2 Type I IFN signaling and viral countermeasures STAT1 STAT2 IRF9 TYK2 JAK1 PMC6008657__F3 Insulin signaling also controls mTOR pathway that inhibits autophagy ULK1 ATG12 MTOR DKFZp686F0183 PMC26952__F7 Activation of specific target genes by TGFB and Wnt pathways LEF1 SMAD4 PMC6387036__F2 HBV- and HCC-related genes in L1 biology RAD21 TERT PMC9425222__F3 DNA Repair Pathway Genes Associated With Ataxia PARP1 LIG1 MRE11A APTX BRCA1 RFC3 RFC4 FEN1 RFC1 RFC2 ATM BRCA2 PARP2 RAD50 RAD51 PNKP PCNA TDP1 PMC2504760__F1 Mechanisms by which diabetes increases cardiovascular disease VCAM1 TNF CD36 PMC2831538__F3 Autophagy regulation in response to stress TSC2 TSC1 ATG12 EIF2A BNIP3 MTOR PMC10137494__F2 Steroid synthesis pathway CYP21A2 CYP11B2 PMC338270__F1 Modification pathway of proteins for isoprenylation/methylation and effects of inhibitors of each enzymatic step ICMT RCE1 ARHA PMC7472700__F3 T-MPs function CGAS CD80 PMC11882765__F1 Ferroptosis Signalling Pathway GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 DHFR SLC3A2 TF PMC7563796__F1 Multiple functions of microglia and macrophages in brain injury MFGE8 CD200 CCL2 PMC7472700__F1 CGAS–STING pathway CGAS IRF9 RELB TRAF6 IRF3 IFNAR2 CSA2 PMC7299722__F1 Effects of doxorubicin on cardiac mitochondrial dynamics and mitochondrial function MFN2 FIS1 OPA1 PMC2816010__F6 Effect of dasatinib on the BCR-ABL signaling pathway PTS BCR BCLAF1 GAB2 ATF2 MYC SRC BCL2 CRK EIF4B MEF2C CBL PMC10671302__F4 Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases CD44 VEGFA CHI3L1 PMC9357805__F2 Microenvironment That Regulates Vascular Wall Stem/Progenitor Cells in Vascular Injury and Repair CCR2 IL8RB RAC1 CSA2 TNF CDC42 STAT3 VAV2 PMC3500853__F3 EphrinB reverse signaling PAK1 ARHA RHO CDC42 PMC6177397__F2 RDGN regulates TGFB signaling transduction in tumor cells.Notes: TGFB binds to TBR and activates SARA, which then recruits and activates intracellular SMAD2/3 protein SMAD2 SMAD4 DACH1 SIX1 PMC5810846__F4 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics TNK2 PMC7260844__F1 Schematic representation the regulatory networks of lncRNAs in major biology activities during brain developmental process NFIB BMP2 ZEB2 GSK3B BDNF OLIG2 SUZ12 HES1 PMC8505078__F6 Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology CD14 LTA PROS1 TES TRO APP tal-1 PMC2634670__F1 Strategies to inhibit the VEGF signalling pathway PIGF DLL4 PMC2577427__F9 Model depicting signaling pathways for TPR-mediated modulation of OLG development and function COX1 TPR RHO PMC5809441__F1 Pleiotropic effects of statins CRP TF PMC11274344__F6 The cancer antioxidant regulation system in therapeutic resistance and scientific questions to be solved ME1 GCLM ME2 KEAP1 SLC7A11 GCLC SLC6A9 NNT MTHFD1 HSF1 MTHFD2 HEL-S-26 HEL-S-64p HEL-75 NADK2 ME3 GLUD1 GLS PMC7167007__F1 Interferon signaling pathway TBK1 TLR4 STAT2 IRF9 IRF3 TYK2 IFNAR2 IFNAR1 PMC5385290__F2 Folate Nutrition and Blood-Brain Barrier Dysfunction MTR DHFR TYMS PMC10937114__F3 Hypoxia affects adenosine signaling pathways in erythrocytes(A) AMPK-BPGM signaling pathway ADORA2B AMPD3 SPHK1 PMC8307963__F2 Syndromes of Thrombotic Microangiopathy: A Critical Appraisal on Complement Dysregulation HEL-S-62p C9 C4B_2 CD46 PMC8005659__F1 Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3B/Beta-catenin signalling pathway NLRP3 RUNX2 GSK3B LRP5 LRP6 AXIN2 IL1B GSDMD SIRT3 PMC8139204__F2 CD36 Signaling in Diabetic Cardiomyopathy VAMP2 VAMP3 VAMP4 IRS1 CD36 PMC4205853__F2 Schematic comparing signaling cascades activated by EPO in microglia and macrophages MTOR PMC8120550__F8 Overexpression of ING3 is associated with attenuation of migration and invasion in breast cancer AGER RELA TNP2 SMO REL STAR PMC6412134__F1 Targeting GBM CSC-mediated chemo/radio resistance by small molecule inhibitors L1CAM RAD17 ATM EGFR SHH SMO ADAM10 ABCG2 PMC5842951__F1 Rho kinase signaling and cardiac physiology ROCK2 ROCK1 FHOD3 ARHA PMC5810846__F1 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics LEF1 APC LRP6 PMC5694448__F6 A model of leptospire-induced apoptosis in macrophages through bid-induced release of AIF/ Endog signaling pathway CASP8 PMC6048953__F2 Insulin action and resistance in obesity and type 2 diabetes TSC2 TSC1 FOXO1 RHEB PMC5810846__F3 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics RRH PMC9685520__F1 Phase separation drives the formation of biomolecular condensates in the immune system TBK1 CGAS ZMYND8 PMC2100342__F3 Activation of NFKB via the classical and the alternative pathway VCAM1 RELA RELB REL LTBR PMC4813427__F6 Summary of NOP receptor signaling ARR3 ADRBK1 PMC3437536__F1 Class I phosphoinositide-3-kinase (PI3K) signaling pathway BAD PTEN RAC1 FOXO1 PMC5578103__F3 Schematic diagram illustrating the mechanisms of how the estrogen receptor (ER) coordinates with the epidermal growth factor receptor (EGFR) to affect the cell growth in the lung adenocarcinoma EGF EGFR SRC MTOR PMC8544609__F2 Hormetic ER stress signaling elucidated in HSCs ELF2 TH SEL1L RUNX1 ATF4 DDRGK1 ORAI3 XBP1 ORAI1 STIM1 STIM2 PMC2266095__F2 Schematic presentation of the NFKB signaling network in radiation-induced adaptive radioresistance GADD45B ATM SSB PMC11941885__F3 Mechanical stress-related podocyte injury CLCF1 TRPC5 TRPC6 ARHA RAC1 EPB41L5 APOL1 CDC42 PMC2872497__F4 Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment NODAL SMAD2 SMAD4 PMC11941885__F2 Immune-mediated podocyte injury HEL-S-62p IRF7 FH IRF3 CD55 CD80 MYD88 TIRAP PMC8664902__F5 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis PDE4D FHIT PRKCZ NGF MGLL SMARCA4 MMP2 TBX1 CYLD ESRRB ITSN1 DEFA1B CLN3 TGFBR3 NOS2 ROS1 RGS6 MSRA RUNX3 AREG DLG2 ALG13 BRD7 LAMA4 RAI1 ADAR TNC SLC6A3 PARK2 GRID2 STK11 GRIA4 GNAO1 WWOX PRKCE TANK EBI3 CUTA HEL-S-15 NLRP6 SLIT3 KIF11 CAMK4 E2F2 VWF CAMTA1 PRKDC TUSC3 GNE ATG16L1 RAB11A TCN2 PIGN OPHN1 RC3H1 ARID1B CDH18 CREBBP MICAL3 NFATC2 ZNF816 KLRD1 RELA STAT4 CNTN4 RPL10 TRAF2 PMC8664902__F6 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis GPX4 CTSS MSR1 UCN FGF8 NRAS KCNMA1 HIF1A CACNA1A FLT1 KHSRP TBX1 NOTCH1 FURIN CDH2 NPC2 ZNF7 NPPC FOXO1 RXRA KCNQ2 PARK2 HSPG2 NR1C2 STK11 BCL2 KCNQ3 ACLY SIRT1 SUMO2 TANK PTPRK NLRP6 CD83 CD300A SLIT3 PTPRS U2AF1 RRM2 ZBTB16 EMP2 HEL-S-70p NFATC1 LTBP1 ADORA2A SSR1 CABIN1 NBL1 SNAP47 SLC23A2 EYA4 FOLR2 HCN2 TIRAP PHLPP1 PMC6263010__F1 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus SOX2 PTCH1 GFAP PMC10778012__F5 tRF-mediated translational regulation RPS28 YBX1 JAG2 EIF4E PMC6263010__F2 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus SOX2 PTCH1 GFAP SHH PMC10778012__F1 Oncogenic signaling can drive changes in the transcription of tRNA genes MYC MTOR PMC3058926__F5A Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations CLDN1 NBEA SAA1 S100A9 SERPINA3 OSMR CITED2 PINK1 HNF4A SCD LPIN1 CYP4F3 GPX2 TXNIP RAP1GAP CETN3 IFNGR1 DUSP3 PMC7260686__F5 Herb-target-signaling pathway interaction network FOS BMP2 EGFR TGFBR2 VEGFA MYC IL6 RB1 HRAS HMOX1 CBL BMP4 VEGFC WNT3 MAX BCR PTCH1 FZD2 GRB2 FZD7 TERT AKT3 PMC2628394__F15 Biological network representing the schizophrenia p-value ranking EMX2 NR4A3 EIF4E ABCG2 HIF1A SOX9 RXRA HLA-F PMC3931732__F9 CHC-1 and EPN-1 promote actin polymerization in response to CED-1 signaling EPN1 MEGF10 MEGF11 PMC2628394__F16 Biological network representing the bipolar disorder p-value ranking PDX1 HLA-DPB1 NPY ATF4 ATF2 GHR CREM ATF1 JUND JUNB WTAP CD74 PMC9232097__F7 Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer IGF1R CCNA2 PLK1 MAPK8 NR3A2 PGR CSNK2A1 EGFR TGFBR1 GSK3B MAPK14 TGFBR2 PDPK1 FGFR1 KDR PTPN1 SRC IL2 MAPK1 NOS2 KIT CTSK PTGS2 MAPK10 ARHA HRAS HEL-S-130P RHEB RXRA HEL-S-22 CASP3 CDK2 LCK NR1C2 JAK3 SYK EPHA2 PPARG HEL-S-72p PMC5912970__F2 Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens GAL PMC6492940__F4 Essential metabolites HEL-75 ASPA PRX PMC6492940__F5 Inflammation, apoptosis and cell survival APAF1 STAR GPER BAX PMC3325001__F2 Modes of Hh pathway signaling SUFU PTCH1 SMO PMC9314556__F1 Mitochondrial Epigenetics Regulating Inflammation in Cancer and Aging TBK1 CGAS IRF3 BAX PMC3325001__F1 Hh signaling pathway SUFU PTCH1 SMO PMC7755476__F11 Cell cycle and (b) TGF-beta-signaling pathway regulated by the E2F alteration in brain and CNS cancer BAMBI NODAL BMP2 ORC6 PITX2 SMAD2 APC ARHA CDK7 ORC2 IFNG FST SMC3 CDK2 CD7 MDM2 RGMA CDK4 RAD21 AAR2 PCNA SKP2 PMC7576986__F1 IFN-I induction and viral counteracting actions TBK1 TLR8 TLR7 TLR4 TLR9 IRF7 TRAF6 IRF3 TLR3 PMC4380423__F5 Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasis IL10 TH CSF3 IL6 TNF IL5 CCL1 IL7 TREM1 CD2 CSF2 CSF1 IL1B PMC11092636__F3 Exercise activates the EGFR/insulin signaling PRKCZ MAP2K4 MAPK14 CA3 PTEN MTOR SHC3 INSR PRKCA HEL-S-11 PTPN11 APP RAPGEF1 STXBP1 MAPK10 MAP2K5 GYS1 SNAP25 TBC1D4 MAP3K12 CRK TSC2 MAP2K1 HEL-S-42 MAP3K14 PMC4437334__F1 Active killing of motoneurons through death receptors under pathological context NGF IFNGR2 IFNGR1 FADD LTBR IFNG PMC5663622__F3 Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials F2 APC RHO PMC5038604__F4 Protein-protein interaction network of the overlapped DEGs MUC13 GLB1 NEU1 ACTN1 HEL114 CFTR PMC5595906__F4 Results of PPI network analyis MYB MRPS7 UCHL5 TBPL1 USP19 MAPK9 GNB2 MRPL14 PLK1 TFAP2B AKAP11 ELP4 MAPK3 LSM6 TAF9 BCL2L1 TFDP1 RPL23A PSMD7 PRPF31 SMARCA4 ATXN1 PSMC6 RBM4 HELLS MAP3K1 SET BAG3 BCAM DACH1 ATF3 PPP4C RGS12 HMGCR CBX4 BCOR MAX GLI3 YY1 RBM14 HEL113 PCNA ADD1 ACTA2 PRPF3 EEF1A1 SSU72 CCNC TFCP2 CHD3 NR2F2 CDK4 TSPYL2 NFYA BAX FUS ALPL HNF4A SNRPB NRP1 HNRNPC RBMX TPT1 RNF10 URM1 WBP11 PMC4486731__F3A BRAF gene: From human cancers to developmental syndromes MDM2 GRB2 CDK4 PMC2781329__F4 Schematic diagram for HO-1 modulation of signaling pathway and adiponectin, EET levels, and vascular function ADIPOR1 ADIPOR2 PMC3218540__F2 Folate metabolic pathway DHFR PMC4421076__F6 Sustained Interleukin-1B Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids IL16 IRF8 IGFBP1 IL1R1 PKD1 IL1B BAX PMC5004238__F4 Schematic illustration of axon-microglia interactions and the CASP6/p38/TNFA signaling pathway in the spinal cord dorsal horn of male rodents CASP6 BDNF TRPV1 PMC6640082__F1 Mammalian Heme Synthesis Pathway FECH UROD UROS HMBS ALAS2 PMC6640082__F2 Heme Synthesis Metabolon FECH UROD UROS HMBS TMEM14C ALAS2 SUCLA2 PGRMC1 CP PMC7464452__F2 Possible endothelial–mesenchymal and epithelial–mesenchymal interactions in BPD-PH FGFR1 FGF2 FGF10 SHH FGFR2 PMC4029965__F7 Predicting Response to Preoperative Chemotherapy Agents by Identifying Drug Action on Modeled MicroRNA Regulation Networks PGR UGCG ERBB2 BUB1B TTK STK4 CDADC1 AURKB PMC8539587__F1 Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens NLRP3 TLR5 TRAF6 MYD88 AIM2 IL1B PMC7305518__F5 Graphene induced activation of macrophage signaling pathway (Zhou et al IRAK1 TRAF6 IRAK4 MYD88 PMC4316204__F2 Remodelling the extracellular matrix in development and disease TH MMP14 MMP2 MMP11 CDKN1B MMP9 PMC4316204__F3 Remodelling the extracellular matrix in development and disease MMP3 MMP14 MMP2 FGF10 LRP5 ARHA BTBD7 FGFR2 PMC3375273__F6 TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation NFATC1 TRAF6 MAP3K7IP1 FADD PMC9219669__F2 Apoptosis and (in) Pain—Potential Clinical Implications CASP3 NGF CASP9 BCL2 TNF CASP8 BAX PMC11012756__F5 Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer PIN1 PLK1 BRAF WEE1 MDM2 CDK4 PTEN MTOR FBXW7 FAT1 AURKA PMC9454904__F2 Current Understanding of Asthma Pathogenesis and Biomarkers CXCL1 CXCL5 CXCL8 HEL-S-92n TNF PMC8371935__F1 Phylogenetic Analysis of Core Melanin Synthesis Genes Provides Novel Insights Into the Molecular Basis of Albinism in Fish PMEL TYRP1 MC1R PMC8549349__F7 ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway TLN1 ITGB1 PMC6322652__F1 mTORC1 and mTORC2 as regulators of cell metabolism in immunity TSC2 TSC1 PTEN SGK1 PDPK1 RHEB PMC2755611__F1 Regulation of aging: does autophagy underlie longevity? TSC2 SIRT2 TSC1 NRF1 PTEN RAF1 EIF4E SIRT1 RHEB PMC5686720__F11 Work model for NLRX1-mediated MAVS degradation during viral infection TBK1 NLRX1 IRF3 MAVS PMC22672__F8 Orb6 kinase is proposed to be part of a regulatory cascade contributing to the mitotic control and responding to the Ras1 and Cdc42-dependent morphological control pathway via the Pak1/Shk1 kinase PAK1 WEE1 CDC42 PMC4646251__F12 The signaling pathways involved in GnRH-induced ERK activation (red arrows) and ErbB4 cleavage (blue arrows) ERBB4 FYN EGFR SRC HBEGF NRG1 PKD1 PMC5555103__F1 Fatty liver diseases are initiated by aberrant hepatic lipid metabolism, and sirtuin 1 (SIRT1) activation plays beneficial effect against the process through inhibiting de novo lipogenesis and increasing fatty acid Beta-oxidation ELOVL6 TG NR1C1 SIRT1 PMC8639500__F4 SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells SOX2 FOS IL11 IL24 KLHL21 IL6 IL6R SOX9 STAT1 DUSP5 NFATC2 IL23A FOSB IL36G BCL2 DUSP8 JUN STAT3 PMC12041846__F6B DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity CREBBP CAMK4 PAWR CDK5 CREM ATF1 GNAS PPP1R18 COMP CALY PMC12041846__F6C DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity TH ChAT CHRNA7 KEAP1 NFE2L2 SLC18A3 SLC5A7 IL6 ACHE TNF HMOX1 CHRM5 CHRM4 FYN CHRM3 NGFR CHRM1 KCNJ2 BCL2 CHRM2 NOS2 PMC12041846__F6A DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity HTR1B GSK3B CD44 GNA13 ARHA MAP3K5 GAP43 RYR2 FOXO1 MMP3 CASP3 GNA11 LEP PC KALRN SRC JUN HTR2B PMC11594113__F1 Insulin-like growth factor 1 signaling pathway BAD MDM2 MTOR PMC3076503__F4 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hippocampus CS GPX1 MIPEP COX7A2 UQCRFS1 ATP6V1E1 ATPAF2 ACSL6 SLC25A18 ZNF183 GSTZ1 NDUFAF1 DDC NDUFB10 PPA2 AGXT OGDH HK2 SDHB SDHC COXFA4 GAD1 RXRA HEL-S-162eP ABAT CPT1A GRB2 NR1C2 NDUFA10 SUCLA2 ACSL3 PMC5764254__F7 Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src ATF4 GSK3B SRC PMC5413074__F6 Canonical (NFKB1) pathway requires the NEMO (NFKB essential modulator) complex (IKB kinase A, IKB kinase B, IKB kinase G) to phosphorylate IKB, leading to its degradation CCL21 CD40 IL6 PMC3076503__F5 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hypothalamus CS GPT UQCRFS1 ATPAF2 SLC25A18 ZNF183 GSTZ1 DDC NDUFS1 NDUFB10 PPA2 AGXT DLAT HK2 GLS2 MAP2K2 PIK3R3 GAD1 COX17 ABAT GRB2 NR1C2 NDUFA10 ECHS1 EHHADH ALDH2 PMC7495669__F5 Gene-vocalization links SEMA3A TPH2 NTS DDC FKBP14 NDNF HEL-S-64p MAGOHB RANGRF SIM1 PPIL3 WBP11 PAX8 PMC6003316__F5 Genes of gossypol pathway enzymes and their expressions MVK IPP MVP PMC6355689__F3 Pathway representation for dopamine metabolism TH DRD5 DRD3 SLC6A3 DDC SLC18A2 HEL-S-53e MAOA DRD1 DRD2 ALDH2 PMC5409508__F2 Material Cues as Potent Regulators of Epigenetics and Stem Cell Function RHO MTOR PMC4440595__F2 The BMP/SMAD signaling pathway BMP6 SMAD4 ID1 SMAD1 DKFZp781O1323 PMC10987721__F2 Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases TLR4 FFAR3 ICAM2 FFAR2 TG PMC3754249__F2 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations HEL-S-26 ACO2 BNIP3L ACLY BNIP3 HEL-S-133P HEL60 MAL PMC3754249__F3 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations TKTL2 PGAM1 HEL-S-133P HEL-S-281 PMC6685213__F4 Kaposi Sarcoma TBK1 CGAS TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 TLR8 IL16 TLR7 TLR4 MAVS PMC7716495__F1 Activated and inhibited Wnt/Beta-catenin pathway APC GSK3B PMC8200981__F1 Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications HMGB1 TLR4 TLR9 MPO HEL-S-28 MMP9 CTSC RAC1 MYD88 PMC7716495__F2 Hallmarks of diverse categories of Wnt/Beta-catenin targeted agents in cancer LRP5 PORCN DKK1 PMC7716495__F3 Graphic overview of Wnt/Beta-catenin signaling pathway targeted interventions in cancer studies COX2 COX1 GSK3B PORCN PMC8061201__F2 Function of LncRNAs in diabetes-related renal inflammation and fibrosis NLRP3 EGR1 PMC8848980__F6 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus FRAS1 FREM2 PTCH2 VAV1 NOTUM LTB FREM1 COL1A1 DLX3 BTK LEF1 THBS3 PTCH1 LYN CD40LG KRT71 FOXE1 FZD10 HOXC13 FOXN1 PMC8848980__F3 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus PIK3CD BAMBI HGF CX3CR1 FLT4 WAS CSF2RB RGS14 BTK PIK3AP1 BASH NGFR COL1A2 CHRM2 XB GRAP CD3G CSF2RA SELE RELN NAIP BMP2 COL27A1 LTB TNF CFTR PRKCB CHAD NCF1 LAT PMC6679375__F3 Wnt-EarlyEx tumors show expression of Wnt-associated pathway signatures BAMBI CTBP2 FZD3 CSNK2A2 SOST GSK3B MYC SMAD4 PORCN DKK1 SOX17 MMP7 FZD2 SRC DVL2 FZD10 SFRP4 CSNK1A1L FOSL1 RUVBL1 PSEN2 APC LRP5 PRKX LRP6 TCF7L2 FZD4 PRKACG SFRP5 DKK4 FZD5 CHD8 AXIN1 NR1C2 APC2 CSNK2B CTBP1 SENP2 DKK2 CCND3 FZD1 NKD2 CXXC4 CCND2 NKD1 CCND1 FZD7 SFRP1 CTNNBIP1 AXIN2 TCF7L1 FRAT2 RUVBL2 CER1 WIF1 DVL3 DVL1 NLK LEF1 CREBBP EP300 PSEN1 hCG_2014051 FZD8 PMC6913804__F1 Schematic overview of cell death pathways affected by Coxiella burnetii effector proteins BAD BAX PMC10741569__F1 Viruses modulate the EGFR signaling network RIDA VGF EGFR PMC3323522__F7 A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity CYP27A1 CYP7A1 HSD3B7 PMC11544528__F5 Mechanisms by which NR4A1 regulates osteoporosis and adipogenesis via the Notch signaling pathway RUNX2 HES1 PMC3877685__F2 Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks HEL-S-62p BRAF CCND1 PMC4123127__F1 Hippo in the Path to Heart Repair LATS1 LATS2 PMC8618018__F2 Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves PC ATP6 DDB1 RFWD2 FDXR PMC3529568__F1 TGFB latency, activation and signal transduction SMAD2 SMAD4 ARHA FURIN PMC8275829__F2 ADAMTS Proteases ADAMTS12 ADAMTS2 ADAMTS5 ADAMTS9 ADAMTS20 ADAMTS19 ADAMTS17 ADAMTS8 ADAMTS6 ADAMTS7 ADAMTS15 ADAMTS14 ADAMTS13 FURIN PMC2758485__F1 Wnt/PCP signaling and its effects on organogenesis BBS4 PMC2834542__F5 Actin cytoskeleton signaling pathway as represented by Ingenuity Pathway Analysis ARHA ATR CRK PMC3901886__F1 Schematic representation of ligand-activated AHR signaling AHRR AHR PMC7053300__F5 MiR-17 family miRNAs are predicted to target the p21/CDK/E2F1 pathway to modulate the G1/S transition of the cell cycle under oxidative stress SMAD4 CCND1 CDK4 RB1 RBL2 RBL1 CDK6 CCND2 PMC9647060__F4 Transcriptome and metabolome analyses provide insights into the relevance of pericarp thickness variations in Camellia drupifera and Camellia oleifera RO60 CAD PMC2864141__F1 Models of checkpoint control in (a) S RAD1 CDS1 POLE WEE1 RAD17 HUS1 CRB2 PMC7040013__F4 Pathway analysis reveals predicted gene targets enriched in predominately nervous system signaling pathways for focal (A) or diffuse (B) injury cohorts CREBBP SOS2 GRB2 RRAS RALB SOS1 PMC4075091__F5 Domain structure of p62 and its interacting partners KEAP1 TRAF6 NBR1 PMC8185227__F3 LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma EGR1 BMP1 MYBBP1A FOXK1 LRP6 PTEN DKK1 MTOR CDK8 PTTG1 STAT3 FOXA2 PMC12221920__F3 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration NFATC2 MPDZ AJUBA SCRIB LATS1 LOXL1 LATS2 PMC12221920__F4 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration TIAM1 LRCH4 MOB2 DKK3 SRC LATS1 MTOR HSF1 PMC12221920__F1 Two states of the Hippo pathway in the mammalian tumor microenvironment MOB2 LATS1 PMC5036969__F3 Mitochondria and Cancer YY1 PTEN MTOR PMC10374481__F7 HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations APAF1 EGFR BIRC3 BAX PMC2834616__F4 EGR3 and miRNAs involving in signaling pathways and regulatory networks in schizophrenia and nervous system EGR1 NGF NPY NGFR BCL2 ARC NRG1 DRD2 BDNF GAD1 GABRA4 PMC5008272__F7 Monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model APC GSK3B LRP5 DKK1 PMC6612409__F2 Intestinal disease-related pathway including MAPK signaling pathway, NF-kappa B signaling pathway, calcium signaling pathway, and chemokine signaling pathway F2R CS TRADD IRAK1 TRAF6 IRAK4 MYD88 IL18 TLR4 PTGER1 SRC NOS2 IL1B CD14 CXCR1 PTGS2 BDKRB1 TNF PLN HEL-S-102 NTSR1 EDNRA PRKCB TRAF5 RELA TNFRSF1A LBP RAF1 HTR2A TRAF2 PMC9585326__F1 Mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle TLR4 PPA2 IRS1 INSR PMC6878846__F1 Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome RIPK1 TRADD IRAK1 TRAF6 IRAK4 MYD88 TNF MAP3K7IP1 OTULIN TRAF2 PMC9024452__F6 Restricted Activation of the NFKB Pathway in Individuals with Latent Tuberculosis Infection after HIF-1A Blockade VIT IL18 CYP27B1 PMC6977016__F3 Role and mechanisms of frequently-studied traditional herbs in treating NAFLD NLRP3 FXR1 MYD88 SIRT1 PMC3266662__F3 Correlations of genes in central carbon metabolism with SPPR ENO1 ENO2 GIP CIT EN2 EN1 tal-1 RPE LAT MAL HEL-S-68p PMC7966921__F3 Myristoylation in regulating TRIF-related adaptor molecule (TRAM) during LPS-induced TLR4 inflammatory responses TLR4 IRF3 MYD88 MAL PMC8490662__F8 Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway MSC FGF2 CD44 CD74 OSM PMC8968907__F4 Mitochondrial anti-apoptotic dependencies of hematologic malignancies: from disease biology to advances in precision medicine CXCR4 PTPN11 CD44 BCL2 CD40 MCL1 CXCL12 BAX PMC3984536__F3 HCV life cycle and points of intervention DGAT1 EGF APOB CLDN1 EGFR LDLR NPC1L1 EPHA2 TG APOE CD81 PMC6096387__F8 Proposed mechanism of JuA-mediated AB clearance ABCG1 ABCA1 APOE CD36 PMC8778593__F2 Therapeutic implications of exosomes in the treatment of radiation injury MMP11 TGFBR2 NOTCH1 TRAF6 LATS2 PMC5770815__F1 Kynurenic acid (KYNA) synthesis along the kynurenine pathway and its mode of action KYNU AHR IDO2 PMC5770815__F2 Kynurenic acid (KYNA)-mediated pathways of inflammatory signaling DKFZp686L0365 AHR SRC IL6 IL4 TNF IRF-1 PMC6316386__F1 Transient receptor potential (TRP) channels and itch signaling TRPC4 TRPV4 HTR7 S1PR3 LPA TRPA1 TRPV3 TSLP HTR2B TRPV1 TRPM8 PMC8954173__F1 Genetic Landscape of Peripheral T-Cell Lymphoma ITK LCK VAV1 ZAP70 GRB2 TYK2 JAK3 RHO JAK1 LAT STAT3 PMC6774191__F6 ERKI/II (MAPK) can serve as a convergence site for multiple extracellular signals known to induce plasticity in mature neurons GRB2 SRC SOS1 PMC4881570__F2 MiRNAs in cardiac fibrosis pathway COL3A1 FOS SMAD2 SPRY1 IL6 RHO JAK1 STAT3 PMC6920353__F4 Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks ENO3 CCR2 RASD2 EPO TLR9 STAT2 AGTR1 IRF9 EGFR IFNGR2 AHNAK SSTR2 BCAN AGTR2 CCR1 STAT1 CXCR3 ZNF217 CIC SIN3A BDKRB2 SP1 PMC9185618__F2 Targeting the methionine addiction of cancer HEL-S-61p MTAP HEL-S-182mP PMC4498940__F3 Changes in the pRb and p53 pathway promoting cell cycle passage in high-grade central chondrosarcoma, as found in the present and previous studies MDM2 CCND1 CDK4 PMC5390360__F4 Interaction between AMPK and AKT on the phosphorylation: Growth factor activates TKR and promotes the activation of AKT via IRS1/PI3K/PDK1 signaling PTEN IRS1 PMC4881570__F3 MiRNAs in cardiomyocyte apoptosis pathway PRKCE ROCK1 GSK3B MYC ARHA MCU PTEN TNF HIF1A MTOR CASP3 APAF1 CASP9 UNK CCND1 BCL2 JAK1 BNIP3 STAT3 PMC5758710__F1 G10’s modified pathway diagram for the alfalfa lignin system CCR2 CAD CCR1 PMC5390360__F2 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway TSC2 BAD GSK3B MDM2 BCL2 ULK2 EIF4E MTOR TG EIF4B HK2 PMC5390360__F3 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway TSC2 ULK1 TSC1 EIF4B RHEB PMC5805998__F3 Functional enrichment of combined differentially expressed gene list in severe asthma across all tissues CD14 SNCA CS PTGS2 RALA CCL4 HEL110 CCL2 RHEB MAPK6 SPI1 RELA KLF4 ITGAX JUN TF PMC8211286__F1 Schematic presentation of IL-6/JAK/STAT3 pathway in pancreatic cancer cells and tumor microenvironment STAT3 PMC8523922__F2 IL-36 in the Pathophysiological Processes of Autoimmune Diseases IL2 MYD88 IL4 PMC7049637__F2 Proposed mechanisms involved in the anti-fibrotic activity of curcumin by inhibiting the activation of PSCs to acquire myofibroblast-like phenotypes IL16 ACTA2 IL6 PMC7049637__F3 Proposed mechanisms involved in the anti-fibrotic activity of rhein EGFR SHH CDH2 STAT3 PMC3348440__F1 Target-derived NGF mediates axon growth and synapse assembly in sympathetic neurons via endocytic signaling mechanisms NGF PMC4105941__F1 The Self-Limiting Dynamics of TGFB Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation SMAD2 SMURF2 SMAD4 PMC2134838__F2 ALTERNATE ROUTES FOR DRUG DELIVERY TO THE CELL INTERIOR VAMP3 VAMP4 VTI1A YKT6 PMC8812242__F6 Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction TH AGA MAL TOB2 PMC8612001__F3 Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy WNT4 SMAD2 CDH2 WNT5B PMC8898354__F1 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases CCK PYY ARC PMC8507396__F2 PLCG1 in regulation of VEGFR2 and FGFR1 signaling PLCG1 FGFR1 FRS2 GRB2 PMC8898354__F3 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases ARC LEPR PMC9496810__F7 White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy APC LRP5 LRP6 PMC5770468__F8 Model depicting the suggested signaling pathway modulated by CSs to inhibit HIV-1 gene expression MAPKAPK2 CS EGFR GRB2 SRC PMC4132214__F1 Transcriptomic differences between OVCAR3 and SKOV3 and PCA after interaction with the mesenchymal cells SHOX2 RUNX2 TSC22D3 ERBB3 SNAI2 DKK1 CDKN2A CEBPD EDN1 PC TWIST1 ERBB2 NRP1 BDNF PMC2774854__F1 Schematic overview about TCR-dependent signalling pathways FYN LCK GRB2 IL2 ORAI3 ORAI1 LAT STIM1 CDC42 PMC4132214__F2 Pathways modified in OCC upon MSC contact related to adherence, migration, and invasion DKK3 CDH11 POSTN VEGFA ATF3 HAS3 NID1 MMP3 SULF1 VAV3 OGT TXNIP MAP3K8 DIPLA1 BDNF PMC8140999__F5 Translational control by eIF2A phosphorylation ELF2 EIF2A PMC8523993__F8 Performance Assessment of the Network Reconstruction Approaches on Various Interactomes PIK3CD PIK3R1 FOXO4 PRKCZ MAPK3 NRAS LPA RB1 MAP2K6 FGFR2 PDPK1 CDK6 CCNE1 PRKCA FBLN5 NF1 MSH6 SRC MAPK1 PRKCI PRKCQ ERBB3 MAP2K5 HRAS BRCA1 FOXO1 TSC2 TSC1 PRKCB BRCA2 CDK2 GRB2 APOH PRKCH IGF1R MAP2K4 EGFR ATM APP CDK4 FOXO3A MAP2K2 SPRY2 CBL PIK3C2B EP300 MAP2K1 MMP12 ERBB2 PIK3CA PIK3R2 PMC4586477__F2 TAA-specific CD8+ T cells often lack co-stimulation for an immune response against tumors ITK PAK1 FYN CSK FOS VAV1 ZAP70 GRB2 SYK CD80 LAT CDC42 PMC11087724__F1 AMPK/mTOR signaling pathway involved in regulation of feed intake in chickens (created with BioRender TSC2 TSC1 MTOR RHEB PMC11087724__F2 Leptin and insulin signaling pathways in the hypothalamus of chickens regulating neuropeptide genes (created with BioRender POMC SOCS3 NPY IRS1 FOXO1 STAT3 PMC11087724__F3 Detailed leptin signaling pathway in the hypothalamus of chickens (adapted from “Cytokine Signaling through the JAK-STAT Pathway”, by BioRender SOCS3 NPY STAT3 PMC4586477__F5 Many signals overlap with PI3K/AKT/mTOR pathways in tumor-specific CD8+ T cells TSC2 BAD TSC1 HEL-S-28 MDM2 GRB2 CDC37 PTEN EIF4E RHEB PMC7905169__F3 Regulation of NF-kB activation by ubiquitin ligases and DUBs CYLD TRAF6 TAB3 PMC6097464__F11 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set ROCK2 ACVR1 SMAD2 TGFBR1 TGFBR2 MYC SKP1 TNF RBX1 IFNG FST THBS2 THBS3 SMURF2 MAPK1 THBS1 SP1 INHBB INHBA PMC7905169__F4 The regulation of TGFB pathway by ubiquitin ligases and DUBs USP15 SMAD2 SMURF2 SMAD4 WWP1 SMURF1 USP11 PMC7230639__F1 Mechanisms of lactate-BDNF interaction following physical exercise BDNF SIRT1 FNDC5 HCAR1 PMC6097464__F10 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set FER BAD ARHH HEL-S-28 PURA VEGFA SHE SHC4 PTEN CRK PAF1 CRKL PMC6303891__F7 Putative mechanism is demonstrating how the loss of SEMA5A can trigger EMT SEMA5A GSK3B PMC3896784__F8 Model of FTO regulation of leptin action and glucose homeostasis through the LepRb-STAT3 signaling pathway SOCS3 LEPR STAT3 PMC5603666__F10 Graphic representation of pathways for furanodiene-induced cell apoptosis and for doxorubicin-resistant MCF-7 cells outcomes BAD HEL-S-11 BAX PMC7807149__F6 Lycopene Production Pathway in Triple KOE PC GOPC RPE PMC10999658__F7 Molecular mechanism underlying CE accumulation in ccRCC and suppression of cancer progression upon CE depletion VHL SOAT1 MTOR PMC6778377__F6 Schematic illustrating how Nrf-2 activation regulates phenotypic modulation KEAP1 GCLC HEL-S-44 PMC4388604__F1 WDFY1, a new player in the TLR-TRIF pathwayTLR3-stimulated signaling is fully dependent on TRIF, and TLR4 stimulates two signaling pathways, one of which is dependent on TRIF TLR4 TLR3 PMC3695741__F2 Nicotine and Pathological Angiogenesis TRPC4 BAD TRPC1 TRPC5 PMC3764071__F1 One-carbon metabolism and glutathione (GSH) synthesis and metabolism HEL-S-61p INA MTR PMC8482636__F7 Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer INMT SMYD3 MSC PMC4313732__F2 Cytosolic nucleic acid pattern recognition and activation of ISGs RNASEL STAT1 CH25H CGAS RNASE1 IRF7 IRF3 AIM2 IRF-1 MAVS IFI16 USP18 PMC8434532__F4 Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer ATF4 EIF2A XBP1 PMC6695817__F1 Mitochondrial antiviral signaling protein (MAVS)-dependent antiviral signaling pathway IRF3 IFNAR2 IRF-1 MAVS IFNLR1 PMC5380511__F7 A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance PIK3R1 MAPK9 CHUK MAPK8 NCK2 MAP2K4 SMAD2 TGFBR1 GSK3B TGFBR2 RALA SMAD4 RB1 RALBP1 E2F3 CDK6 NCK1 STAT1 PRKCA CASP9 MAPK1 RAD51 CDK4 CAMK2D MOS SOS2 MAPK10 RALB RAC1 PIK3R3 CBL MAP2K1 BRCA2 NFKB1 GRB2 PIK3CA JAK1 RAF1 SOS1 TGFA CDC42 STAT3 PMC6115922__F1 Honey Bee Immune Pathways—Highlighting Genes Implicated in Antiviral Immune Responses AGO2 UNC80 FADD PMC4746893__F1 Cyclin D/cyclin-dependent kinase (CDK)4/6/retinoblastoma (Rb) Pathway and the cell cycle CDK2 CCND1 CDK4 CDC2 CDK6 PMC6972667__F4 Linking the protein C pathway with EPCR‐ and ICAM‐1‐binding IEs in cerebral malaria APC MMP9 VWF PMC8140811__F7 Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers ANGPT2 MYH9 ACACA EGFR VEGFA CHEK1 TP53BP1 ANGPT1 KDR NRP1 CXCR4 NOTCH1 BCL2 SYK CXCL12 PMC6294046__F4 Druggable proteome across five classic cancer pathways HEL-S-26 EGF KIT BRAF ALK EGFR NRAS PIK3CA PTEN HRAS MTOR PMC5337876__F10 Schematic diagram depicting proposed mechanism for the Wnt signaling pathway activation during differentiation of ADSCs into insulin-producing cells LRP5 LRP6 PMC8913504__F3 Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases IL2RA JAK1 MTOR IL2RB FOXP3 PMC6404501__F2 Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury MTOR RHEB PMC2831127__F7 Proteins Secreted By Embryonic Stem Cells Activate Cardiomyocytes Through Ligand Binding Pathways ROCK2 HGF ERBB2 FOS IGFBP1 IGFBP2 ARHA RAC1 JUNB STAT3 MEF2D PMC7760417__F1 Virus entry initiates the interferon (IFN) response IRF3 TYK2 MYD88 IFNAR1 MAL IFNLR1 PMC3678388__F1 Canonical ATR signaling pathway and functions of newly identified regulators.(A) ATR signaling is activated in response to single-stranded DNA gaps in the genome MCM6 CINP MCM2 CDC5L CDC6 TOPBP1 FAAP24 ATRIP FANCM ATR CEP164 BACH1 PMC8324723__F1 Forecasting early onset diminished ovarian reserve for young reproductive age women PGR ADRB2 SLPI BGLAP PRL BAG1 TSG101 POMC TBP SRA1 CD163 RELA STAT3 SUMO1 PMC3678388__F3 ATR recruitment to some DNA base lesions proceeds through a mismatch repair-dependent mechanism.Mismatch repair proteins may contribute directly and indirectly to ATR recognition of some times of DNA damage TOPBP1 ATRIP ATR PMC8156839__F1 Survey of Bacterial Microcompartment Distribution in the Human Microbiome GRM2 GRM3 GRM6 PMC6002666__F4 Predicted models for central metabolisms of A OMP AMT PMC9021375__F8 Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis CD14 TLR4 LPA MYD88 PMC9475012__F1 Neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review BACE1 ATG3 EIF2A CDK5 BDNF IRS1 PMC7780227__F1 MAPK pathway: activators and inhibitors ATF2 RHO CDC42 PMC2975271__F9 Schematic model for regulation of mTOR pathway signaling through interaction of the p53 target Plk2 with TSC proteins TSC2 PLK2 TSC1 MTOR PMC8705144__F3 Hippo Pathway in Regulating Drug Resistance of Glioblastoma PRCC NF2 LATS1 LATS2 PMC5120213__F1 Schematic model of the three apoptosis signaling pathways CASP3 MSC CASP9 CASP10 ATR CASP8 BAX PMC8705144__F1 Hippo Pathway in Regulating Drug Resistance of Glioblastoma NF2 LATS1 LATS2 PMC9630567__F1 Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury KEAP1 ATF4 XBP1 PMC9613996__F5 Hypothesis of how loss of Gamma-secretase function causes ferroptotic stress MAML1 GPX4 SELENOP SEPHS2 NOTCH1 LRP8 PMC8236109__F1 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net CDC6 FOXM1 BRCA2 EGFR SP1 HDAC1 BRCA1 PMC3425078__F5 Effects of NO and nitrosative stress on apoptosis APAF1 PMC8236109__F2 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net CDC6 FOXM1 BRCA2 EGFR CCND1 BRCA1 PMC2596245__F3 EET- or sEHI-mediated antihyperalgesia occurs through 2 distinct mechanisms TES PBR PMC2882520__F3 Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5) NR3A2 C1QBP INS FES CREB1 SLC4A1 BIRC2 PRC1 PC MCM2 PELP1 PNMT TOPBP1 SLC12A3 CCNB1 GFER MED28 HEL-S-19 C1S MYLK PMC83988__F10 Signaling pathways for NFKB activation by IL-1B TRAF6 RAC1 MYD88 CDC42 PMC2570606__F6 Proposed model for the effects of hypoxia-induced energy stress on them TOR pathway in HNSCC cells TSC2 TSC1 MTOR RHEB PMC5904076__F2 HSPs and the DNA damage response (DDR) HEL-S-102 ATM ATRIP ATR H2AX HSF1 PMC7930050__F7 GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia CDK4 CDK6 PMC7563617__F5 Metformin-induced CSC suppression through AMPK activation and inhibition of protein prenylation by suppression of the mevalonate pathway SQLE FDPS RHO MTOR IPP GGPS1 HMGCR PMC10857240__F1 Proteins and genes involved in chlorophyll synthesis pathway MGP UROD UROS HMBS CPOX POR PMC4200333__F9 Signaling pathways involved in TC adhesion-induced ICAM-1 expression on ECs under flow chamber conditions CD44 SP1 PMC6047913__F6 Enriched target genes of the TFs TCF7, RUNX1, STAT3, and SOX4 in the MAPK signaling pathway NF1 CD14 MOS DAO FLNA ECSIT JUN MPL PMC11940265__F6 Arachidonic acid metabolism pathway, with genes detected in ovary and testis transcriptomes LTA ALOX12 LTB PGC HEL110 PMC4183126__F2 PALB2 links BRCA1 and BRCA2 into a pathway of products of breast cancer susceptibility genes PALB2 BRCA2 RAD51 BRCA1 PMC5904076__F6 HSPs and double strand break repair HEL-S-102 BRCA2 RAD51 POLL LIG1 HSF1 BRCA1 PCNA POLI PMC2765790__F7 Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes NAMPT SIRT1 PMC11940265__F5 Oocyte meiosis signaling pathway, with genes detected in ovary and testis transcriptomes MOS PLK1 IGF1 CDK2 SMC3 CD2 INS STAG3 POR MYT1 REC8 PMC11958968__F3 Network representation of DSF, its modulated targets, and pathways involved in RF PIK3R1 TNLG1B FOXO3A PTGS2 MMP9 FTL ALOX5 PIGS PTEN CTSH TNF MTOR HSD17B10 THPO CYP2E1 NLRP3 RIPK1 CDKN1A HTR2A PLA2G2A ALDH2 PMC12003521__F2 Mouse LrNK cells in other liver diseases (except for liver viral infection and liver cancer) CXCR3 CGAS CXCL10 IL33 TNF PMC11958968__F5 Cluster analysis for DSF-modulated targets MMP9 ALOX5 TNF PTGS1 CYP2E1 GUSB NQO1 CCR1 MGST1 ITGB8 MMP2 CYP3A4 VCAM1 CXCR4 CCR7 HEL-S-44 CR2 ALDH2 PMC3400941__F1 Model depicting PI3K signaling BAD PTEN MTOR IRS1 PMC9654827__F8 Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma SNCA SNCB PMC5051518__F1 Simplified diagram of the adaptive and apoptotic pathways of ERS ATF4 EIF2A XBP1 BAX PMC11628441__F1 MTOR signaling pathway in astrocytes (simplified scheme) TSC2 TSC1 PTEN HABP2 RHEB INSR PMC5540209__F1 PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression IGF1R GRB2 IRS1 PMC4698658__F1 Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers TIGAR LIPE SCO2 MGLL IMPACT CPT1C MYC HIF1A MTOR FASN CD36 PMC6594283__F7 Possible signaling transduction pathways induced by SIRT7 in LPS-treated DCMECs SIRT7 IL16 TLR4 MAP3K7IP1 BAX PMC3667869__F1 Resistance to EGFR targeted therapies EGFR PTEN AXL PMC5054714__F2 DEGs in cell cycle pathway Up-regulated and down-regulated DEGs are highlighted in red and green, respectively UBE2F CCNA2 MAD2L1 SMAD4 CCNH RB1 CCND3 TFDP1 CHEK2 CCNB3 PTTG2 CDK2 CCNB2 ATR PRKDC YWHAG TGFB1 PCNA RBL1 CCNE2 PMC7463613__F2 Notch signaling pathway in cancerogenic events NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC11202427__F1 BMP pathway in cardiomyocyte differentiation SMAD4 SMAD1 DKFZp781O1323 ISL1 PMC3035565__F11 WNKs: atypical protein kinases with pleiotropic actions PAK1 WNK1 ARHA RAC1 WNK2 WNK4 PMC11202427__F2 WNT signaling pathway APC GSK3B PMC5054714__F1 DEGs in p53 signaling pathway Up-regulated and down-regulated genes are color-coded in red and green, respectively BAD CDK2 UST PTEN ATR PMC8418611__F4 Several signaling pathways regulated by circRNAs in osteoporosis TRADD RUNX2 BMP2 SMAD2 APC GSK3B LRP5 SMAD6 SMAD4 LRP6 SMURF1 SMURF2 TRAF2 SMAD1 PMC6781400__F7 Schematic illustration of the role of CyclinD1 to regulate Dicer promoter in ICC CCND1 CDK4 CDK6 PMC4641790__F8 Mammalian target of rapamycin complex 1 (mTORC1) is required for mouse spermatogonial differentiation in vivo RARA RPS6KB1 KIT NR1B3 EIF4EBP1 SOHLH1 SOHLH2 PDPK1 PMC7541099__F3 Putative mechanisms of SARS-CoV-2 infection TLR7 MMP9 FURIN MYD88 ACE2 TMPRSS2 PMC8999129__F3 Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review EGFR PTEN MTOR STAT3 PMC317204__F8 Schematic diagram illustrating a model for the antagonistic roles of Dp110 and DPTEN in Drosophila growth control IRS4 IRS1 PMC7541099__F2 Therapeutics under clinical trials targeting the cytokine storm in SARS-CoV-2 infection HEL-S-62p SOCS3 MSC MMP9 CRP TPO MYD88 ACE2 ADAM17 STAT3 PMC9141180__F2 Soyasapogenol C from Fermented Soybean (Glycine Max) Acting as a Novel AMPK/PPARA Dual Activator Ameliorates Hepatic Steatosis: A Novel SANDA Methodology F10 MAPK14 NPC1L1 DRD2 SPHK2 HEL-S-26 ITK GRM2 POLE NR1i1 PDE10A SCD HEL-S-11 GC MDM2 EPHX2 BCHE FNTA CA4 ABCB1 CTSL PSEN2 HMGCR AURKB CNR2 CYP2C9 CDK2 NR1C2 OPRK1 SPHK1 PRKCH AKT3 TERT CHUK F2R BRAF PGR TTK EGFR ACHE HEL-S-104 CNR1 SHBG PTPN1 APP CCND1 CYP1A1 NR1H3 RORC MALL INCENP S1PR1 FAAH NR1C1 PRKD1 AURKA IKBKB PIM3 TYMS PTPRE SYK PSENEN PYGL PMC11668946__F1 Ferroptosis in ischemic stroke: Animal models and mechanisms GPX4 LPCAT3 PLAA FACL4 SLC7A11 HEL-S-64p ALOX15 APP SLC3A2 PMC11668946__F3 AA participates in the deacylation/reacylation cycle of membrane phospholipidscPLA2A cleaves glycerophospholipid molecules at the sn-2 position to produce AA LPCAT3 FACL4 PMC7680860__F2 Synthetic CO2 fixation pathways for acetyl-CoA synthesis HEL107 RPE PMC3085878__F3 TLR-induced microbial resistance TBK1 CD14 TLR5 TANK TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 IRF-1 PMC7599540__F4 Src Homology Region 2 Domain-Containing Phosphatase-2 (SHP-2) targeting on melanoma cells EGF HGF PMC5297719__F1 Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat? IGF1R GSK3B GSK3A SRC PTEN PMC3356073__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade TSC2 RICTOR BAD TSC1 MDM2 PTEN MTOR RHEB PMC6723883__F4 model of CFHR1-3 participation in Andes orthohantavirus (ANDV) infection response CFHR3 CFHR1 SIRPB1 PMC4050365__F5 Single-stranded RNA loading to AGO-clade Argonaute proteins AGO2 DGCR8 DROSHA PMC4325211__F3 Placental oxidative stress triggers the expression of transcription factors to regulate angiogenesis and trophoblast invasion SP1 SP3 KLF8 STAT3 PMC8154696__F10 An overview of ODE exposure induced mitochondrial dysfunction in microglia and BSCs MFN1 PINK1 MFN2 CGAS TLR9 IRF3 TNF TFAM PMC6136429__F3 CIN activates cGAS-STING signaling TBK1 CGAS CSF1R RELA TRAF3 RELB IRF3 TRAF2 PMC8564337__F6 Reduced MAGI3 level by HPV18E6 contributes to Wnt/B‐catenin signaling activation and cervical cancer progression MAGI3 PMC7224363__F1 Chemical reactions triggered by Δ9-fatty acyl-CoA desaturase, EC:1.14.19.1, also known as Stearoyl-CoA-desaturases (SCD), introducing a double bond and thus affecting lipid metabolism GPX4 APC AXIN1 LRP6 FZD4 HMGCR BAP1 PMC9927011__F1 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer CXCL1 IL13 CXCL5 CXCL2 STAT3 PMC3581799__F5 Cell-to-cell signaling network generated by ingenuity pathway analysis of differentially expressed genes: Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line) F13A1 CLEC5A FCGR1A FCGR2A CSF3R CXCL3 CCL7 CLEC4E CCL3L3 CCR1 SELL FCER1G HCAR2 NOS2 GAL FCAR IL1B SDC1 IL8RB S100A9 PTPRC NFKBIA TNFRSF1B BCL2A1 TREM1 ITGAX CD36 PMC9927011__F2 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer CGAS CD80 CTLA4 PMC5465238__F1 Schematic outline of intracellular Ras signaling pathways in the suprachiasmatic nucleus (SCN) regulating circadian clockwork EGR1 CRY2 GSK3B JUNB PER2 PER1 PMC8998406__F1 Notch Signaling Pathway by Bioactive Dietary Agents NOTCH1 CCND1 ADAM10 SOX9 PMC2376243__F8 Schematic mechanism of AB oligomer-mediated aberrant PAK activation and translocation in Alzheimer disease pathogenesis TIAM1 FYN CDK5 PMC7281445__F1 Tumor Necrosis Factor (TNF)/TNF-Receptor 1 (TNFR1)-mediated signalling and cell death checkpoints RIPK1 TANK TRADD RIPK3 TNF MLKL PMC5002480__F1 Cross talk between multiple signaling pathways involved in tumor progression and resistance ATM BRCA2 RHO ATR TF PMC6966522__F2 The IL7R structure and signaling mechanism GRB2 JAK3 JAK1 PMC2949446__F1 Luteolin and gefitinib regulation of EGF Signaling Pathway and Cell Cycle Pathway genes in PC-3 human prostate cancer cells EGF GRB2 PMC8610132__F7 miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer TIMP1 PMC6491685__F1 Complement system HEL-S-62p CD59 VTN FH CR1 PMC3561537__F6 Scheme of EGFR signaling pathway activated by NEU3-induced GM3 reduction EGF NEU3 EGFR PMC7717145__F1 Disease-based pathway analysis of genes involved in the pathogenesis of lung diseases and respiratory failure TLR4 NKX2-1 SFTPC PTEN STRAP MBL2 IL5 TNF ACE2 CSF2 CFTR FOXF1 PMC3580961__F2 Transcription at damaged DNA XPC XPA PCNA UVSSA PMC8472588__F9 ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas CD58 MSC MYC IL2RA TYK2 JAK1 IRF4 ROS1 STAT3 PMC4598026__F5 Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells UNC13C PARM1 CMBL CAPN6 CSDC2 LIX1 FIBIN AKNAD1 ASPN CPA1 NRK SEMA5A SEMA6D SEMA6A SEMA3C SLC40A1 SERPINB2 PMC9900921__F7 Simplified de novo sphingolipid biosynthesis pathway UGCG SI FA2H KDSR PMC3906547__F1 Reverse cholesterol transport pathway delivers free cholesterol from macrophages or other cells to the liver or intestine for excretion PLTP LDLR PMC9635594__F3 Schematic diagram showing the role of mucins in cancer metabolism MUC1 TIGAR MUC13 HEL-S-30 PGM2 PFKFB2 ENO1 HEL-S-133P BRCA1 HK2 HEL-S-68p PMC11083431__F6 Possible gene expression changes from enhanced NRF2 signaling and depleted NOTCH signaling in the bile acid synthetic pathway from cholesterol in Keap1F/F::RbpjF/F::AlbCre liver at 3 W of age CYP27A1 CYP8B1 NRF1 CYP7B1 ABCB11 CYP7A1 MAFG PMC7545792__F8 Map of Th17 cell signature cytokines and the IL-17 signaling transduction pathway TBK1 DEFB4B CXCL1 CCL11 TRADD CXCL10 TRAF3 LCN2 CXCL3 CXCL2 CCL7 CCL2 S100A9 USP25 IL17RB IL17RC IFNG CCL20 CCL17 TRAF2 FADD PMC6071257__F1 Epstein–Barr virus (EBV) oncoproteins affecting p53 signaling pathways ING4 MDM2 PMC8065646__F3 Examples of redox regulation of specific transcription factors PDX1 KEAP1 PAX4 PMC8065646__F4 Redox targets within insulin secretory pathway and proteins involved in extracellular redox signaling TRPC1 KY SENP1 TRPC5 NOX4 ACE2 PRX ADAM17 PMC9687473__F1 Targeting Adiponectin in Breast Cancer CCND1 BAX PMC12011584__F1 VEGF signaling pathway in stimulating sngiogenesis (By Figdraw2 PIGF VEGFC NRP1 VEGFB NRP2 PMC9635594__F1 Schematic diagram showing the mucins role in cancer stemness and chemoresistance MUC1 MUC13 SOX2 FOXO3A EGFR CD44 LRP6 GPR49 TSPYL5 MUC4 MUC5AC CXCR4 BCL2 ABCB1 LMO2 STAT3 BAX PMC9635594__F2 Mucin’s role in epithelial to mesenchymal transition (EMT) MUC4 MUC5AC CDH2 STAT3 PMC7597043__F1 Mechanisms of venetoclax resistance BTK BCR BCL2 CD40 SYK MCL1 PMC5425748__F2 Illustration of the multiple signalling pathways for TGFB in the VSMC In the normal state, TGFB is sequestered by microfibrils, bound to fibrillin-1 through LTBP-1 and fibulin-4 interactions, until its required release TGFBR1 TGFBR2 LTBP1 PMC7599957__F1 Network diagram of the model PMVK MVD FDPS LDLR MVK IPP ACAT2 PMC4894418__F5 Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing CD14 NLK DAO MAX FLNA RAF1 BDNF FAT2 TRAF2 PMC7716161__F3 Role of IL-17 in the pathogenesis of acinar duct metaplasia, pancreatic intraepithelial neoplasia, and pancreatic cancer DCLK1 ADM PMC6497964__F8 The signaling pathway from EPHB6 to catecholamine biosynthesis in AGCCs TH EGR1 EPHB6 TF PMC10820593__F5 Common adjuvants and proposed mechanisms CGAS IRF7 APP IRF3 TNF PMC5391303__F1 Pharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses BTK BCR CXCR4 LYN SYK PLCG2 PMC8513284__F10 FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway ELAVL1 TLR4 RAB10 PMC4491123__F1 The miRNA biogenesis and function AGO2 DROSHA RAN TARBP2 PMC8946846__F9 Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway VASP IRAK1 VWF PMC11172514__F1 The mechanism regulating NLRP3 inflammasome activation in canonical, non-canonical, and alternate pathway NLRP3 IRAK1 TRAF6 IRAK4 MYD88 CASP8 FADD GSDMD PMC10513492__F7 Lipid and atherosclerosis and (B) AGE-RAGE signaling pathway in diabetic complications map of Chaihu Anxin Capsule for their potential treatment of depression TH NLRP3 EGR1 IRF3 TNF TIRAP SELL PMC4062707__F2 Signalling pathways activated by chemokine receptors PAK1 ROCK1 SRC ARHA RAC1 MTOR JUN CDC42 PMC1480427__F1 ω3 LC-PUFA and ω6 LC-PUFA biosynthetic pathways TNLG7C GLA PMC7812220__F8 Protein-protein interaction network of hsa-miR-126-5p-related differentially expressed genes CA3 RGS18 RGS17 AQP4 SLIT2 CALCRL SOX17 PPBP PALMD PROK2 P2RY13 FOXF1 GKN2 PTPRB SNTN TLR4 ZFP36 SCN4B CDCA7 FAP STX11 MFAP4 GJB2 SCEL CAV2 EMCN EMP1 SELE MGAM MMP10 AKAP12 LRRK2 PTGS2 TMPRSS4 FUT3 HMMR EDNRB MYZAP CLEC14A NCAPG FHL2 PGC KLF2 MME PMC7812220__F9 Protein-protein interaction network ITGA1 MMP10 XLKD1 ATF3 HCTP4 PPBP PLOD2 FUT3 SULF1 NUF2 HMMR APOLD1 CDCA7 BUB1B NCAPG FAP FHL2 CCNB1 KLF2 EMCN KIF15 TCF21 SELE PMC5610833__F1 Catecholamine synthesis pathway TH PNMT DBH PMC4344511__F4 Estimation of multi-factor mediated dysregulations affected by the module INA EGF KIT HEL-S-1 CTCF EGFR ADAM12 SNX6 PTEN AVIL AHR ANXA2 TF ELL PMC8449320__F7 FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis SPARC FAP JUN PMC4417485__F1 Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity FBP1 GIT2 PMC9600294__F5 Adipokines as Regulators of Autophagy in Obesity-Linked Cancer ULK1 IGF1 ATG12 LDLR MTOR DKFZp686F0183 NR1C1 BAX PMC8350063__F7 LGI1 governs neuritin-mediated resilience to chronic stress LGI1 HDAC5 IRS1 MEF2D PMC8640120__F1 Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers TH GC CD40 PMC11800652__F5 Metabolic maps of Sulfurovum species from Kebrit Deep BSI RTCA POR PMC5471512__F8 Insulin resistance in LMC metabolism, inflammation, and contractility UNK PTEN IRS1 PMC6701246__F1 Mechanisms promoting macrophage phagocytosis of AC by lipid mediators ANXA1 GPR32 FPR2 RHO IL1B GPR18 STAT3 PMC5439269__F3 Eukaryotic DNA mismatch repair (MMR) POLE MSH6 MSH2 PCNA PMS2 PMC5413367__F1 Targeting molecular pathway EGF EGFR SRC PMC6908425__F2 Deletion of fumarases leads to changes in carbon fluxes and amounts of metabolic enzymes SDHC RPIA CIT RPE MAL PMC8072122__F1 Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways APC LRP5 MDM2 LRP6 PTEN MTOR PMC6908425__F4 Deletion of glycogen synthase in a ΔfumABC strain restores carbon fluxes without changes in amounts of metabolic enzymes SDHC RPIA REL CIT RPE SDHD MAL PMC9315443__F5 Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors CD27 IRF7 CD40 MYD88 ICOS PMC4668848__F2 Influence of MAP on TLR9 signaling PAK1 TLR9 IRAK1 IRAK2 TRAF3 SRC TRAF6 IRF3 IRAK4 MYD88 FADD PMC4234068__F1 COMPLEMENT REGULATION IN RENAL DISEASE MODELS CD59 C9 FH C7 C6 CR1 PMC7444072__F5 Interaction networks of DMCs according to severe features of PE NUMB KRT19 DPYS TICAM2 PTPRN2 CCDC6 PCOLCE2 LRGUK SPP2 STK32A BEND7 DLGAP2 FAT10 HEL-S-70p BANP EBF3 ZIC4 INS-IGF2 ADGRB3 PTPRT IGF2 VCAN DROSHA FGFR3 ROBO2 GAST TRIM26 RXRA KSR2 HLA-F RPL17 HLA-DPB1 MLKL PMC4904104__F5 Disturbed metabolic pathway related to NAFLD and HD-TE treatment PTDSS1 PC LPA TG PSD PEMT PMC6261473__F1 Nrf2–Keap1 signaling pathway MAF KEAP1 PMC12073235__F1 Primary to specialized metabolic flow in Cannabis PAOX AANAT PMC3568263__F2 Defective counterregulation and hypoglycemia unawareness in diabetes: Mechanisms and emerging treatments CRH NTS ARC PMC4905266__F1 Intersection between the Ras and the SUMO pathway in cancer GRB2 SAE1 PMC8577254__F2 Retinoic acid in the commitment to meiosis CYP26A1 CYP26B1 CYP26C1 ALDH1A3 HEL-S-53e RDH10 ALDH1A2 PMC3218933__F3 Embryonic pathway signaling leads to induction of epithelial-to-mesenchymal transition EGF TWIST2 TWIST1 DLL4 JAG2 SNAI2 SMO DLL3 AXL SNAI3 KLF8 PMC3218933__F2 Cross-talk among embryonic signaling pathways and experimental inhibitors IHH DKK3 SMAD2 JAG2 GSK3B SMAD4 PTEN DKK1 HES1 FOXC1 GRB2 SFRP1 SMO PMC5390606__F2 A simplified network identified by IPA pathway CDKN1B CCNB1 CCND1 PMC9013942__F2 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms CAP1 HSF1 TRAF2 SIRT1 PMC9013942__F3 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms ROCK2 CXCR4 CCND1 SRC JAK1 STAT3 BAX PMC4339951__F1 TGFB pathway in muscular dystrophy opn TGFBR2 PMC3475374__F1 Conceptual schematic of M MTR POR PMC7610648__F3 Replication-coupled ICL repair NEIL3 SLX4 FAAP24 PMC7196371__F12 Functions of exercise in AD HDAC3 HDAC2 BDNF IL1B PMC8485521__F3 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells GRB2 PMC8883456__F6 Main repair pathways for trapped topoisomerases in humans TRIM41 GCNA PARP1 SPRTN RNF4 MRE11A FAM111A TDP1 PMC8485521__F2 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells PTEN MTOR PMC9569450__F1 Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study HAAO KYNU KMO AFMID PMC8385797__F5 Smoking induces sex-specific changes in the small airway proteome HEL-S-62p SPOCK2 FH CD55 FSTL3 PMC7281786__F5 Mitochondrial mediated immune functions and cell signaling NLRP3 TLR9 FPR1 IL1B MAVS IFNG PMC9280276__F2 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer GPX4 SLC7A11 MT1G EGFR SLC3A2 MTOR PMC9280276__F3 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer GPX4 LPCAT3 ASCL4 SLC7A11 PMC9280276__F1 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer GCA GPX4 FACL4 SLC7A11 HEL-75 TFRC SLC3A2 ARF1 ACSL3 STAT3 PMC5364922__F7 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population RPS6KB1 PDE3B SOCS3 MAP2K1 PRKAA2 PPARGC1A PRKAA1 IRS1 SHC1 FOXO1 INSR PMC9280276__F4 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer STAT1 GPX4 PROS1 TYRO3 SLC3A2 IRF-1 CD81 PMC11231459__F2 Tumor progression targeting PDGFR-B signaling pathway, contributed to the pathogenesis of DFSP (created with Biorender.com) STAT1 STAT2 PTEN MTOR COL1A1 PMC9280276__F5 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer GPX4 SNAI1 FACL4 TWIST1 SLC7A11 NF2 TFRC SLC3A2 MTDH PMC11231459__F5 Understanding of FGFs/FGFR signaling pathway in pathogenesis of DFSP (created with Biorender.com) FGFR1 FRS2 GRB2 FGFR2 PMC9519154__F1 Exploring autophagy-related prognostic genes of Alzheimer’s disease based on pathway crosstalk analysis BAD SCAI MOS ATP6 BAGE PIR INS MCU CASP3 HEL-S-11 APP TUB FADD SELE PMC10375783__F2 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy CGAS GPX4 LPCAT3 FACL4 ATM SLC7A11 POR PMC10375783__F3 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy STAT1 HMGB1 LPCAT3 FACL4 ATM SLC7A11 SLC3A2 TGFB1 IFNG PMC11985419__F9 ICAM-1-Mac-1 mediated NET formation mechanism in response to LPS or LTA LTA TLR4 CIT PMC9535304__F4 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress HDAC3 GPR55 KEAP1 MAFK TRAF6 RAC1 PMC2685460__F7 Induction of Distinct TLR2-Mediated Proinflammatory and Proadhesive Signaling Pathways in Response to Porphyromonas gingivalis Fimbriae CD14 RAC1 MYD88 TIRAP PMC4491123__F2 Targets of miRNAs in different cell types of developing mouse lungs ADD3 APC KLF5 SSH2 NOTCH3 TIAM1 HEL-S-108 CDKN1A SRGAP1 NOTCH1 SHH SMO BDNF RBL2 PMC3440872__F4 Model showing a role for Yap in governing cardiac growth and survival by interlinking the Hippo, IGF, and Wnt pathways IGF1R APC GSK3B LATS1 LATS2 PMC10373097__S1 Rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy PLN MTOR PMC6797510__F10 HOTAIR competitively binds to miR‐206, thereby promoting STC2 expression, activating PI3K/AKT signalling pathway AGO2 STC2 PMC5964020__F2 Cortisol and catecholamine metabolism TH PNMT DBH PMC7936909__F7 Most correlated MAPK signaling pathway enriched in KEGG mapper STS FLNA PMC2756058__F1 Pathway of cellular processing of cobalamin (OH-cbl) and location of main enzyme defects in the pathway leading to methylmalonic acidemias and cobalamin metabolic disorders MCEE MMAA MMACHC MMADHC CBL PMC6274736__F1 Schematic diagram of c-mesenchymal–epithelial transition (c-MET) activation signaling pathways HGF ALK EGFR GRB2 STAT3 PMC6274736__F2 Targeting HGF/c-MET pathway in digestive system cancers by microRNAs HGF MMP2 VEGFA MTOR STAT3 PMC3435197__F2 Spectrum of somatic mitochondrial mutations in five cancers HEL-S-26 CYB PMC8584253__F7 PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway CD47 SOX2 MYC MTOR PMC3549672__F2 Ubiquitination in Signaling to and Activation of IKK MIB1 IRF3 TRIM25 MIB2 PMC8519338__F1 Macrophage Activation Syndrome and COVID 19: Impact of MAPK Driven Immune-Epigenetic Programming by SARS-Cov-2 CD14 TLR4 MYD88 ACE2 IL1B TLR3 PMC4104414__F1 Figure shows the endothelial response to a high salt diet SMAD2 PTEN TGFB1 PMC3549672__F3 Ubiquitination in Signaling to and Activation of IKK BCL10 TRAF6 PMC4453619__F7 Molecular genetic model (adapted from ; ; ; ) LRP5 LRP6 TCF2 FZD5 PMC7738893__F1 Action of monoclonal antibodies (mAb) in cancer therapy APC ZAP70 VEGFA SRC SYK CTLA4 MTOR FADD CDC42 STAT3 BAX PMC7738893__F3 Molecular mechanisms for impaired antibody therapeutic activity in cancer IL10 CD7 C6 PMC6302140__F11 Schematic depicting the proposed molecular mechanism by which citrate regulates cellular redox signaling pathways in BMSCs SGSH RAB27A GOLT1B MYL12B ATP6V1D DCXR COX7B EDF1 PMC9634730__F1 Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment MYC FOXP3 PMC9535304__F2 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress MAF KEAP1 RBX1 BACH1 PMC8605525__F8 Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3 RUNX3 STAT4 PMC4012776__F1 Trim21 negatively regulates the DDX41-mediated signaling pathway TBK1 IRF7 TRIM21 DDX41 IRF3 PMC9099524__F5 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer EGF COX2 VHL SRC TRAF6 MAP3K7IP1 IL1B STAT3 PMC3591623__F7 Model for the putative mechanism by which Fsk-cAMPi negatively regulates IL-2R signaling in human T-cells IL2 JAK3 JAK1 PMC7189297__F1 Relationship between EPO and FGF23 metabolism FGF23 EPO SCD PMC6984609__F1 Role of autophagy in the maintenance of intestinal homeostasis and potential mechanisms by which defective autophagy may contribute to CD development CHUK GSK3B CLDN2 RIPK2 MTOR OPTN NOD2 FOXP3 LRP3 NLRP3 IL18 IL16 TLR4 IL22 RAB2A IL1B IL10 LRRK2 IRGM IRF3 CASP14 IFNB1 IL6 TNF PTPN22 CASP3 ERN1 EIF2AK4 BCL2 MCL1 TIRAP PMC9099524__F1 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer EPO MMP2 VHL PMC9099524__F2 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer COX2 IL1B STAT3 PMC6109480__F1 PD-1/PD-L1 signaling and reprograming in T cells APC LCK GIP PTEN MTOR LAT PMC6689979__F2 Subcellular compartmentalization of sphingolipid metabolism opn SKI KDSR PMC8641543__F5 Inhibitors of nucleotide synthesis SLC25A38 SLC6A9 SHMT1 SFXN1 TYMS MTHFD1 HEL-S-51e DHODH MTHFD2 PHGDH MTHFD1L PMC3307959__F5 Unconventional roles of kinesins in cell signaling KIF26A GRB2 APP GDNF SMO CIT PMC6383653__F6 Signaling pathway activated by OxPAPC PAK1 FYN SRC XPA RAC1 PMC4604749__F4 Life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics TSC2 TSC1 NCL HEL-S-92n DDA1 RHEB PMC6383653__F4 Proposed model for the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1 signaling axis in HGF-mediated lamellipodia formation HGF RAC1 SPNS2 PMC3128772__F6 Cell signaling between rNSCs and hMSCs in coculture GFAP NOTCH3 TGFB1 PMC4633353__F7 Constitutive control of AKT-1 gene expression by JUNB / CJUN in ALK+ anaplastic large cell lymphoma: a novel crosstalk mechanism SRC JAK3 JUNB MTOR JUN STAT3 PMC7726326__F7 Gene interaction network of upregulated and downregulated DEGs in TP-treated PC1 (A,B, respectively) and PC2 cells (C,D, respectively) identified by STRING software using a high confidence interaction score (0.700) SQLE HELLS CENPH EBP FGF2 DHCR24 NOP2 CENPK FUS CENPP DTL MMP3 CLSPN PLAT MCM2 FDPS FOSB GNAL ACLY SRGN PMC3599046__F2 Toll-like receptor signaling pathway in response to MDV infection CD14 CTSK LBP TRAF6 FADD TLE2 TIRAP ELL PMC7761032__F2 Potentials and Pitfalls of a Human Cervical Organoid Model Including Langerhans Cells STAT4 TYK2 JAK3 JAK1 TRAF2 STAT3 PMC3599046__F1 JAK/STAT signaling pathway in response to MDV infection PIN1 EPO PMC9030480__F2 Translational Strategies to Target Metastatic Bone Disease PTH CCL2 TARP PMC3917750__F1 Dual regulatory effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on neuronal apoptosis BACE1 PCSK9 BAX PMC5256122__F1 Representation showing the mutations associated with the RAS/RAF/MEK/ERK pathway observed in melanoma GNA11 BRAF NRAS MDM2 CDK4 PTEN MTOR CDK6 PMC6400990__F2 Schematic overview of glycine metabolism and six genetic loci for glycine in/near genes encoding enzymes related to glycine metabolism PSPH GLDC PHGDH GCSH PMC8745614__F5 Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells COL3A1 ADAM15 ATP1A1 GSTM1 SNRPC RBPMS HP1BP3 RRM2B ZC3H11A HEL-S-108 TCEA2 TIMP1 SPG20 GSTM4 GNAS CP PMC8601173__F1 Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: G‐aminobutyric acid and D‐aminolevulinic acid PTS CIT CPO MAL PMC9204890__F5 Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease SHD TPM1 ACTN1 SNX5 MYD88 HAAO RFFL PHKB AHCYL1 PTPRH BAT2L UBN2 PLEKHM2 OPA1 PMC9643771__F1 Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer TBK1 CGAS IRF3 PMC2930805__F1 Metabolic signaling pathway of candidate pathway TSC2 TSC1 PTEN MTOR IRS1 PMC11519876__F1 Reelin signaling pathway in Alzheimer’s disease (AD) VLDLR SRC DAB1 PMC7986695__F2 Crucial cells and molecules involved in postsynaptic responses in the regenerative niche at the vertebrate neuromuscular junction (NMJ) MMP3 MUSK LRP4 PMC6447849__F1 Biogenesis of miRNA AGO2 DGCR8 DROSHA POLI PMC5468653__F3 Prolific nicotine production in the genus Nicotiana evolved from stepwise duplications of two primary metabolic pathways MPO DAO PMC3729926__F6 Aldose Reductase Inhibition Enhances TRAIL-Induced Human Colon Cancer Cell Apoptosis through AKT/FOXO3a-dependent upregulation of Death Receptors BCL2 FADD BAX PMC7280878__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 VASP HEL2 FLNA HEL-S-99n HEL-S-15 BCL2L1 WAS CHD4 CCL2 MAP2K6 PFN1 MMP3 SNX2 GNG11 CDK4 JUN ARHGEF7 FOS GSK3A ARHA TNF EIF4G1 HLA-B HLA-C HLA-A MMP14 HEL-S-93 PXN CDC42 PMC9400233__F5 Two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma TFCP2L1 SMAD2 KLF4 SMAD4 PTPN4 RHOF INHBB SIRT1 STAT3 PMC5241319__F2 Autocrine and intracellular complement activation CTSL HEL-S-62p NLRP3 CD46 MTOR IL1B PMC4896923__F1 Involvement of Notch in the regulation of myelination and axonal growth NOTCH2 EGF NUMB RBPJ NGF MAFK F3 NOTCH1 ADAM10 PMC4896923__F2 NRG/Erb signaling in the control of peripheral myelination and axonal growth RET ERBB4 ERBB2 GRB2 GDNF ERBIN MTOR BDNF RAPGEF2 LINGO1 PMC5241319__F3 Systemic complement in metabolism HEL-S-62p C4B_2 C5AR2 C1S TG PMC7917964__F10 Ingenuity Pathway Analysis RORC NFE2L2 CEBPA TSLP CEBPB TLR4 NR1i1 AHR HNF4A IL33 PPARG JUN STAT3 PMC7606547__F4 Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen INA ECD PIR FES ADA DES PMC2366099__F1 Folate and one-carbon metabolic pathway HEL-S-61p MTR MTRR PON1 TCN2 PMC4664912__F6 Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog ALB AVP CTSA NR3C2 SCNN1G AVPR2 ATP6V1G3 ATP6V1F EHHADH PMC4876452__F5 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis RNASEL OAS1 OAS2 TLR4 NOD1 TRAF6 SYK IRF3 MYD88 TLR1 TNF NOD2 PMC4876452__F6 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis NLRC4 MPO IRAK1 NLRP12 NLRP2 NLRP6 TLR10 NOD2 NLRP9 NLRP3 LTA TLR4 NOD1 GRB2 CD40 NLRP14 IL1B NLRP10 PMC4876452__F7 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis CASP6 LIMK1 TANK TRADD ROCK1 PARP10 CASP10 LMNA DIABLO HTRA2 GAS2 ZC3HAV1 CASP3 DFFB DFFA APAF1 SPTAN1 TRAF2 CASP8 FADD CYCS ARHGDIB ACIN1 PMC12058784__F3 Related biological functions in bone tissue HMGB1 HEL-S-7 FUS PMC9251379__F4 Molecular Mechanism of Yellow Mushroom (Floccularia luteovirens) Response to Strong Ultraviolet Radiation on the Qinghai-Tibet Plateau TH FECH MAL PMC10453365__F1 Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling COX2 TLR4 IRF7 IRAK1 FOS TRAF6 IRF3 IRAK4 MYD88 JUN PMC7662962__F2 Platelet activation by CXCR chemokine receptors CXCL16 CXCR4 CXCR6 CXCL11 PMC1867370__F9 Root Phenotypes of Wild-Type, noxy2, and coi1-1 Plants Responding to Oxylipins.Ten-day-old seedlings grown on MS medium and in the presence of 9-HOT (25 μM), 9-oxo-C9 (15 μM), or JA (10 μM) DES PMC3531730__F6 Proposed model for the signaling pathway mediating NFKB activation induced by C-type lectin receptors CARD9 BCL10 TRAF6 SYK PLCG2 PMC3183592__F1 Normal hepatic methionine metabolism PC PEMT PMC5347794__F9 Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway GEM EIF2A BAX PMC9355550__F2 Combinatorial Strategies With PD-1/PD-L1 Immune Checkpoint Blockade for Breast Cancer Therapy: Mechanisms and Clinical Outcomes APC PMC5272919__F2 Opportunistic intruders: how viruses orchestrate ER functions to infect cells DNAJB14 DNAJC18 DNAJB12 SGTA PMC10384840__F9 Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells RIPK1 TRADD RIPK3 TRAF2 GLA MLKL PMC4112617__F1 Insulin-like growth factor pathway IGF1R IGF1 IGF2 IGF2R PMC9266441__F2 Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NFKB Signaling Pathway TLR4 COX1 IRAK1 TRAF6 IRF3 IRAK4 CGA MYD88 TIRAP PMC6399612__F9 Myogenin promoter‐associated lncRNA Myoparr is essential for myogenic differentiation POLI PMC9657829__F6 DNA Methylation in Neurological Diseases RELN MBD5 ADK TET2 PMC6164146__F2 Activation and Attenuation of IL-33/ST2 Signaling IRAK1 SIGIRR IL33 TRAF6 IRAK4 MYD88 PMC9657829__F4 DNA Methylation in Neurological Diseases BACE1 PSEN1 APP BRCA1 PMC7778457__F2 FA signaling in the DNA ICL repair pathway REV1 PIN1 PALB2 FANCD2 BRIP1 SLX4 UBE2T UHRF1 BRCA1 BRCA2 FAAP24 FANCM RAD51 RFWD3 ATR RAD51C PMC6100577__F3 Double strand break chromatin stability mechanisms RNF168 RNF8 ATM BLM MDC1 MDM2 BARD1 PARP2 PARP1 CDC2 LIG1 PMC8528729__AF1 MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer POU2F3 ASCL1 YAP1 NEUROD1 PMC10960969__F8 Metabolic pathway of methanotrophs HEL-S-26 CS CYC1 HEL-S-304 OGDH TNLG7C EMP1 HEL-S-162eP PMC3037747__F4 BCR, NFKB, and PI3K/AKT/mTOR deregulation in MCL TSC2 BCR BASH RELA RELB PTEN FAF1 PMC12052849__F5 Proposed working model of apoptosis regulated by USP18 through the PERK-eIF2Alpha-ATF4 signaling pathway ATF4 BAX USP18 PMC7804490__F2 T cell signaling by E3 ligases and DUBs USP15 TSC1 FBXO38 CYLD ZAP70 MDM2 PELI1 FOXO1 LAT CDC42 PMC10545718__F1 Bioactive lipid-mediated regulation of insulin downstream signaling and lipid metabolism in adipocytes: mechanistic overview PDE3B CRAT TG IRS1 NR1C1 CD36 PMC4607871__F2 Spindle assembly checkpoint and error correction MCC CDC20 APC CDC2 PMC10545718__F2 Genetic deletion of lipid biosynthetic and metabolic enzymes on adipocyte metabolism PDE3B ORMDL3 TMEM86A TG CD36 PMC9396482__F1 Wnt/Beta-catenin signaling: a multifunctional target for neuroprotective and regenerative strategies in Parkinson’s disease APC WNT1 CNP DKK1 PMC5765398__F2 Mucosal tolerance in the gut and its breakdown in food allergy FCER1A CX3CR1 IRF8 NRP1 CR1 IRF4 GATA3 PMC5969551__F2 Role of Cic in Ras-MAPK signaling and growth control TEAD3 CIC TEAD4 LATS2 TEAD2 PMC5902686__F7 Putative metabolic pathway of drought stress responses in flag leaves and developing grains of Zhongmai 175 GIP IPP CFI HEL-S-162eP PMC3037747__F2 Cyclin D1, at the center of MCL pathogenesis ATM CDK2 GSK3B CCND1 CDK4 MTOR CDT1 CDK6 PMC7290580__F3 Signaling pathways by cIAP-mediated degradation of TRAF2 and/or TRAF3 TRAF1 TRAF3 MYD88 REL TRAF2 PMC6424867__F6 Arenaviral proteins (NP and Z) inhibit the RIG-I/MDA5 and NFKB pathways IRF7 IRAK1 IRF3 MYD88 MAVS MAL PMC6392423__F8 Protein kinase C pathway for prolactin regulation of metabolic gene expression in prostate epithelial cells as represented by mitochondrial aspartate aminotransferase FOS JUN TF PRL PMC6287621__F1 Specific targets and potential therapeutic strategies to inhibit or slow the progression of CKD HGF NOX4 BMP7 TGFBR3 PMC12041846__F6D DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity MYO6 GRIP1 GRIP2 PICK1 AKAP5 TARP PMC8257731__F1 Detailed drawing of the fine molecular mechanisms of lithium on specific cell targets GSK3B TNF MTOR BDNF XBP1 IFNG STAT3 PMC11076692__F2 46,XX Testicular and ovotesticular DSD NR5A1 DMRT1 WT1 SOX8 FOXL2 FGFR2 SOX9 FGF9 SRY NR2F2 RSPO1 SOX3 WNT4 SOX10 PMC11076692__F1 Genes and mechanisms of sex determination EMX2 NR5A1 LHX9 DMRT1 WT1 FOXL2 FGFR2 GATA4 SOX9 FGF9 SRY NR2F2 CBX2 SOX10 PMC2417187__F7 Activation of the UPR in the absence of H6PD ATF4 HEL-S-99n XBP1 PMC7695361__F7 Mechanism diagram of the KEGG pathway BAMBI SAMD3 E2F4 NGF LRP5 SMAD4 LRP6 HDAC1 CDK6 CCND2 GADD45B COX2 VCAM1 TRAF1 RELA CDK4 IL1B RBL1 PMC6539093__F2 Schematic view of the ERK pathway in response to growth factors, hormones, and mechanical stress FHL1 ANKRD1 SHOC2 ERBIN PMC7460641__F3A Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop BAD AGA SI GAL STH PMC4272446__F2 NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease IKBKG MAPK8 MAPK14 CXCL8 DEFB1 RIPK2 NOD2 BIRC2 NFKBIA RELA BIRC3 TNFAIP3 OTULIN JUN ITCH TAB3 PMC4005353__F1 AGS genes cooperate to metabolize reverse transcription products of endogenous retroelements TBK1 TREX1 IRF3 PMC3426484__F1 Asparagine N-Glycosylation pathway OS9 ST8SIA6 ST8SIA2 MANEA EDEM3 SIAT4C DPM2 RFT1 ALG2 PMM1 ALG3 ALG12 ALG6 ALG10 GMPPB MAN1A2 MAN1A1 ALG11 ALG9 PGM3 DPAGT1 GANAB MGAT3 ALG13 MAN2A2 MAN2A1 MGAT1 DOLK DPM3 DOLPP1 ALG1 MGAT4B MGAT2 PMC8687818__F5 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation EGF FOS EGFR MYC CCL2 INSR RXRA CASP3 CDK2 RELA BCL2 NOS2 JUN GLA SELE BAX PMC8973075__F3 Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome HEL-S-62p CD59 TFPI CD46 FH MSC CD55 TF PMC12128733__F8 Hypothetic molecular mechanisms and modes of the pharmacological action of adaptogen are updated from the authors’ free access publication [66] and authors’ drawings COX2 CRH IL6 TNF PMC8687818__F8 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation CASP3 EGF CCNA2 CDK2 RELA MYC CASP9 CHRM2 JUN PMC7383626__F1 Non–small cell lung cancer tumorigenesis pathways and mutation frequencies are illustrated NF1 RET BRAF ALK NTRK1 EGFR FGFR3 PIK3CA PTEN ROS1 PMC12128733__F9 Effect of Rhodiola extracts on the eicosanoid signaling pathway PTGIR ALOX15 ALOX12 LTBR PMC5320608__F10 Schematic model of TREM2 in the regulation of Beta-catenin signaling and microglial survival WNT3A CCND1 SYK PMC8268497__F6 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development RBPJ MIB1 ADAM10 PMC11502356__F6 Insulin signaling pathway and the shortlisted key mRNA markers TLR4 ATM GSK3B MYC MDM2 SRC BCL2 PTEN MTOR IRF4 FOXO1 STAT3 PMC4599573__F13 Schematic diagram shows that PLB regulates the Nrf2-mediated oxidative signaling pathway and its downstream proteins NQO1, GST, and HSP90 in SCC25 cells.Abbreviations: ROS, reactive oxygen species; GST, glutathione S-transferase MAF KEAP1 NQO1 PMC3989738__F6 Direct target genes of hypoxia-mediated hypoxia-inducible factor-1A (HIF-1A) signaling EDN1 SLC2A3 VEGFA HIF1A HMOX1 HEL-S-133P HEL-S-68p PMC7936035__F7 Not Frozen in the Ice: Large and Dynamic Rearrangements in the Mitochondrial Genomes of the Antarctic Fish COX2 COX3 COX1 ATP6 ATP8 PMC4636767__F5 Schematic presentation of a model highlighting the probable mode of action of AMA on placental development IL16 CXCL10 CCL5 IL2RA IL6 CCL2 TNF CCL3 PMC9540681__F2 Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive EGF IGF1 NGF GRB2 SHE CDK4 PTEN MTOR CDK6 BAX PMC3156782__F2 Wnt/Beta-catenin signaling pathway generated by Ingenuity Pathway Analysis (IPA) NLK MYC MDM2 CD44 AXIN2 WIF1 TCF4 PMC8243607__F6 Transcriptomics identifies key defense mechanisms in rice resistant to both leaf-feeding and phloem feeding herbivores MYB ERF PMC6043822__F6 The main modulated genes and their reciprocal interactions in the cell PTGER2 CCNA2 BMP2 PCOLCE PHLDA1 FLNB RCAN1 CNN3 KRT18 GAST G0S2 ALPL HMMR WNT4 VCAM1 PCOLCE2 CCNB2 THBS1 TGFB1 PMC6559886__F5 Fistein Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro EGFR GRB2 ARHA PMC8139523__F2 Take a Walk to the Wild Side of Caenorhabditis elegans-Pathogen Interactions SGK1 TF PMC7268632__F2 Endoplasmic Reticulum (ER) Proteostasis Network ATF4 EIF2A RTCB TRAF2 XBP1 PMC12004596__F1 Inhibition of T‐cell activation HMGB1 APC LCK ZAP70 CD80 PTEN FGL1 PMC7268632__F3 Novel Outputs of the Unfolded Protein Response (UPR) Related to Learning and Memory Processes ATF4 EIF2A BDNF XBP1 PMC8509383__F2 Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved ANGPT1 SEMA4D CTSC BCL2 PMC8901478__F2 Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class CGAS IRF3 TYK2 JAK1 POR TNF PMC5455318__F2 Hyperinsulinemia on the tumor cell microenvironment and intracellular signaling that contribute to tumor growth and progression IGF1R IGF1 IGF2 IRS1 PMC6122270__F4 Multiple pathways of CD44/CD44v6-promoted CIC motility: CD44/CD44v6 drive CIC motility by activation of signaling cascades as well as protease activation GEM CXCR4 EGFR LRP6 ARHA ADAM10 ADAM17 STAT3 PMC4633447__F4 Schematic diagram showing the possible consequences of SLC7A3 dysfunction on the mTOR and NO pathways TSC2 ULK1 TSC1 PTEN EIF4E MTOR DEPTOR RHEB MLST8 PMC5110160__F10 Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia EEF2K GNB2 HEPACAM LDB1 FLNA MBP HDAC11 PRKCSH HSF1 FKBP2 PDPK1 AATK PPP1R9B CHMP1A APLP1 EPN1 FGFR1 SREBF2 RASSF2 NR1H2 MAFG ROGDI SOX2 USF2 TBX2 GFAP SHE HEL-S-47e PADI2 RAC3 ENPP2 ADRM1 SOX10 PMC8506063__F7 Bioinformatics analysis reveals the roles of cytoskeleton protein transgelin in occurrence and development of proteinuria ME1 OLR1 BAD UCP1 HEL-S-28 MYC CDC37 PTEN RAC1 EIF4E IRS1 BRCA1 TSC2 UBC TSC1 PLTP AQP7 BCR LPL MDM2 GRB2 SYK RBL2 CD19 PMC6122270__F3 CD44/CD44v6 and CIC apoptosis resistance CASP3 MMP7 ERBB4 PC HGF MMP9 GRB2 HBEGF CDC37 LAT PMC6085123__F5 NOD-like receptor signaling pathway STAT1 CARD9 IL18 IL16 TLR4 TXNIP TYK2 IRAK4 JAK1 AIM2 CASP8 PMC2818233__F2 Nuclear phosphoinositide-mediated stress response pathway PDX1 SPOP RBX1 PMC7494507__F2 Regulatory mechanisms of CD47 expression.Regulators of CD47 expression in cancer cells includes cytokines, oncogenes, microRNAs as well as enzymes SIRPA CD47 IL16 QPCTL MYC STAT3 PMC7283076__F1 Cytokine storm induced by SARS-CoV-2 STAT1 CXCR1 IL18 STAT2 IRF9 TYK2 MYD88 JAK1 STAT3 PMC2323406__F4 Stimulus Design for Model Selection and Validation in Cell Signaling EGF EGFR GRB2 PMC7283076__F2 TLR recognizes extracellular PAMPs and initiates the transcription of NLRP3, proIL-1B, and proIL-18 through the NFKB signaling pathway, and oligomerized NLRP3, ASC and pro-caspase-1 form a multiprotein complex that activates caspase-1 NLRP3 HMGB1 IL1B PMC4155598__F8 CDK 4/6 inhibitors sensitize PIK3CA Mutant Breast Cancer to PI3K inhibitors CCND1 CDK4 MTOR CDK6 PMC8113420__F1 Possible mechanistic links between the activation of the PKR-eIF2A branch of the ISR and hippocampal/cortical plasticity under physiological and age-related neurodegenerative conditions ATF4 RAX EIF2A PMC5485424__F9 Schematic model of BRAFV600E signaling-induced epigenetic silencing by H3K27me3 in tumorigenesis SET MAX GC DROSHA JARID2 EZH2 EZH1 SUZ12 AEBP2 EED PMC8459449__F1 Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress HEL-S-26 SENP1 REST FFAR1 PMC8634673__F1 Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome TH CCL20 HEL-S-92n HLA-DQB1 IFNG FOXP3 PMC8429127__F1 Sulforaphane-Nrf2-GSTM1 pathway in the prevention of kidney disease progression: Gene - diet interaction KEAP1 GSTM1 AKR1C1 NQO1 PMC6717205__F1 Schematic overview of glycolysis and mitochondrial respiration F2 HEL-S-133P HEL-S-281 PMC3748992__F5 Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma HEL70 RAC3 DCT TYRP1 CALML3 GNG12 PMC9131252__F1 Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation ERBB4 ERBB2 ARHA MTOR PMC3835203__F1 New mechanisms of NOD-like receptor-associated inflammasome activation NLRP3 TLR4 GBP5 BRCC3 TNF MAVS PMC5732032__F1 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma EGFR SRC PTEN MTOR PMC5286880__F5 Interferon signaling pathway as differentially regulated by ZIKV and HCMV in maternal-decidual and fetus-derived chorionic villus tissues IFIT3 IFITM2 TYK2 IFI35 IFITM1 IFNG BAX PMC2981097__F2 Double strand DNA repair: Homologous recombination and Non-homologous end joining PALB2 ZNF350 ATM BRCA2 BRIP1 RAD50 RAD52 RAD51 H2AX XRCC3 RAD21 BRCA1 PMC5732032__F4 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma LDLR FOXG1 ABCA1 SOX9 BRD4 PMC8088128__F3 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective PIK3CA HUWE1 SCRIB SHOC2 ERBIN VCP FBXW7 RPTOR PMC8980014__F1 CSNK2 phosphotargets, associated pathways, and CSNK2-regulated phenotypes identified in this review IKBKB TSC2 NFKBIA CHUK TSC1 IKBKG RELA EGFR MDM2 PTEN MTOR STAT3 PMC9457836__F5 Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia IRAK1 IL13 IL33 IL6 MYD88 IL5 PMC8424196__F4 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease DTX3L METTL3 DTX1 CXCL10 DTX3 RAB4A DTX4 PARP1 ADAM10 IRF-1 PMC10417792__F1 The MET signaling pathway and the sites of action for MET targeted therapies HGF EGFR GRB2 SRC RAC1 MTOR STAT3 PMC2749725__F1 Coverage of the insulin receptor signaling pathway RS1 OCEL1 BAD GRB2 CRAT PTEN EIF4E GRB10 MTOR CRK PMC3253327__F1 Acute and Chronic Regulation of Aldosterone Production CYP11A1 HSD3B2 STAR CYP11B2 PMC3253327__F2 Acute and Chronic Regulation of Aldosterone Production PC MC2R STAR PMC8424196__F3 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease TBK1 DTX3L DTX1 DTX2 DTX4 PARP1 IRF3 HEL-S-104 FOXP3 PMC8088128__F5 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective BRAF SHOC2 RAF1 PMC7361619__F1 COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches ABCG1 LPL LTB LDLR PON1 MIP ABCA1 ACE2 APOE PMC8124226__F7 Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in Combination with Quercetin Inhibit Colorectal Cancer Development in ApcMin/+ Mice LEF1 FBXW4 APC GSK3B PPP2CA FRAT1 PMC8948217__F3 Notch signaling pathway: architecture, disease, and therapeutics HNF1A TCF2 SOX9 PMC8948217__F5 Notch signaling pathway: architecture, disease, and therapeutics CXCL5 CCL2 GATA3 FOXP3 PMC4988489__F2 The piRNA Pathway: Guardian of the Genome –A Fly’s Perspective ME1 AGA PMC8802807__F12 Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary EGF BTC EGFR HBEGF TGFA PMC7350315__F3 Schematic overview of the classical ATM and ATR DDR FANCD2 RAD17 ATM ATRIP ATR H2AX PMC7350315__F4 ATR signaling pathway is involved in the HPV life cycle FANCD2 RRM2 TOPBP1 ATR GATA4 PMC3696796__F5 Schematic depiction of LB-205 effects on NGF stimulated pathways NGF APAF1 BAX PMC7822850__F8 LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway RBPJ MAML2 PMC9358040__F4 Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial SFRP4 TCF3 APC CD44 LRP6 TCF7L2 TCF12 FZD1 FZD5 RARA MMP7 WNT3 TCF23 TCF20 DACT2 SRC CCND1 CSNK1A1 APC2 TGFB1 PMC6275040__F1 Schematic representation summarizing the transforming growth factors-beta (TGFB) receptor complexes and signaling pathway in endothelial cells SMAD2 SMAD4 SMOC1 SMAD1 HMFT1766 DKFZp781O1323 PMC5299619__F1 The canonical T2R signaling pathway PLCB2 CALHM1 TRPM5 PMC8969576__F3 Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis IL10 CHIT1 CD44 CCL2 CHI3L1 PMC7352656__F1 Molecular mechanisms for acquired resistance EGF IGF1R HGF EGFR PTEN MTOR AXL STAT3 PMC6148305__F12 Hypothetical pathway of MIF-2/D-DT-dependent mechanisms in proximal tubule cell regeneration ATF4 EIF2A CD44 CCND1 SLPI CD74 PMC7880315__F8 Working model of Beta-elemene and RT on tumor growth in NSCLC cells CD44 CDH2 PMC3468386__F1 The canonical Wnt signaling pathway APC CTBP1 INS PMC2675709__F5 Comparison of metabolites and transcripts in glycolysis, tricarboxylic acid (TCA) cycle, and pH-regulating pathways between the wild type (WT) and the stop1 mutant ME1 ME2 GAD1 PMC7071121__F6 Proposed mechanism for RPG in regulating the uterine involution in post-natal dairy cows IGF1R IGF1 IGF2 MTOR IGF2R PMC7261103__F2 Role of renin/angiotensin system (RAS) and kallikrein/kinin system (KKS) in pathogenesis of COVID-19 PLG ACE2 TMPRSS2 PMC8277969__F3 Metabolic reprogramming in cancer: mechanistic insights from Drosophila CSK OGT EGFR MYC SCRIB PMC4369962__F4 Calcium signaling pathway in old nitrate treated aorta PLN TNC BCR CAV3 MCU CAV2 PMC7412701__F6 Schematic diagram and potential mechanisms of sotrastaurin inhibition effect on osteoclast resorption CTSK DCSTAMP ACP5 PMC11262449__F1 Genes involved in glucose sensing, the reward system, sweet taste receptors, the endocannabinoid system, and insulin mediated glucose uptake found to have SNP associations with dietary sugar intake and/or cardiometabolic risk factors in children IRS1 INSR PMC8229527__F1 NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications VAV1 DAP PLCG2 PMC9352970__F2 Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role? NLRP3 VCAM1 TNF MTOR PMC7141637__F1 Proposed model for SARS-CoV-2-associated diarrhea MTOR ACE2 TMPRSS2 PMC7767049__F2 Administration of Beta-AR blockade can enhance the efficacy of RT by modulation of tumor microenvironment in irradiated and non-irradiated tumors CXCR3 CXCL10 CXCL9 LYPD3 HK2 IFNG PMC4865030__F1 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity PALB2 GEN1 BLM BRIP1 SLX4 UBE2T BRCA1 WRN FAN1 BRCA2 TOPBP1 FAAP24 RAD51 ATR DNA2 RAD51C PMC6478283__F13 Identification of key regulatory genes connected to NFKB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network EPOR EGF BAD EPO ATF2 EGFR RELB TRAF6 TPO LPA UNG FGFR2 STAT1 TLR4 ATM HEL-S-11 IL2 JUNB OTOR JUN FOS ARHA TNF NFKB2 VCAM1 NFKB1 STAT4 BCL2 JUND REL RAN PMC4683444__F5 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity KIT CHUK SOCS3 TRADD TNF HRAS IRS1 NR1C1 POMC MAP2K1 NPY NFKB1 DCT KITLG LEPR RAF1 TRAF2 STAT3 PMC12193766__F3 Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology MAF KEAP1 GCLC PMC5622249__F6 Schematic diagram of hypothetical mechanisms underlying chloroquine enhances sensitivity to cisplatin in ovarian cancer cells MTOR DKFZp686F0183 PMC5857537__F2 Molecular alterations in aldosterone-producing benign adrenal cortical neoplasms KCNJ5 ATP2B3 CYP11B2 PMC5386520__F2 Gas6 and TAM receptor signalling BAD NCK2 GRB2 TYRO3 AXL STAT3 PMC11700734__F11 Metabolomic and metagenomic analyses elucidate the role of intercropping in mitigating continuous cropping challenges in tobacco TH MYOF VIT PC HP ARC ABCG2 TUB ABCA2 EMB CYRIA PMC8399382__F1 Metabolic Host–Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD) ATG16L1 ATG12 IRGM DKFZp686F0183 NOD2 PMC4729697__F7 Ingenuity Pathway Analysis (IPA) illustration showing upstream regulation of the pathway for NFKB IL18 HDAC3 NR3C1 TNF PMC5857537__F7 Molecular alterations in cortisol-producing benign adrenal cortical neoplasms PRKAR1A MC2R PMC4743890__F1 Neural circuitry and immunity TLR4 NTS ACHE PMC8945726__F2 Mitochondrial Oxidative Stress and Cell Death in Podocytopathies CASP9 BCL2 CASP8 BAX PMC3461213__F1 Regulatory mechanisms of phosphate homeostasis FGF23 PTH DMP1 PMC3156300__F9 Prolactin-Stimulated Activation of ERK1/2 Mitogen-Activated Protein Kinases is Controlled by PI3-Kinase/Rac/PAK Signaling Pathway in Breast Cancer Cells PRLR GRB2 PRL PMC8600311__F2 Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases HNF4A RHO EPHA2 S100A4 PMC4865030__F2 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity UBE2T MCM7 BRCA1 MCM3 MCM5 MCM6 GIG8 MCM2 ATM BRCA2 TOPBP1 FAAP24 RAD51 ATR PMC8470500__F1 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders TNF IL1B PMC8470500__F2 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders NLRP3 TLR4 CRP MIP PMC7283441__F1 Signaling cascade of apoptosis in traumatic brain injury (TBI) BAD BAX PMC7762483__F5 Oxidative stress-induced activation of AP-1 in an ASK1-dependent manner induces TGFB and galectin-9 expression HMGB1 BTK TLR4 MYD88 TIRAP PMC6873206__F1 YAP regulation by mechanical stimuli LATS1 LATS2 PMC9558365__F1 Wnt/Beta-catenin signalling pathway in Haematological Neoplasms APC GSK3B LRP5 LRP6 PMC9577372__F2 Transforming growth factorB in tumour development SMAD2 ATF2 TGFBR1 SMAD4 TRAF6 ARHA FOXC2 FOXA2 HMGA2 FOXA1 TWIST1 ZEB2 GRB2 TGFBR3 CDC42 PMC8473795__F3 Glycocalyx Impairment in Vascular Disease: Focus on Inflammation NLRP3 VCAM1 MYD88 IL1B PMC3595616__F1 The branched isoprenoid pathway DHCR7 IPP MGA PMC3461213__F4 Overall picture of the physiology of FGF-23 and its role in phosphate homeostasis FGF23 PTH DMP1 PMC7826455__F6 Role of miR‐362 in cervical cancer SMAD2 SPTBN1 SMAD4 PMC2892459__F5 Overlay of IfnB timecourse analysis onto the macrophage pathway using BioLayout Express3D IFIT2 SOCS3 EIF2AK2 CASP2 MYD88 STAT1 GBP1 TLR7 IFNGR1 PSMB9 IRF-1 IRF2 STAT2 IRF7 CXCL10 TNF CYBB TLR3 IL15 TIFA TNFSF10 TNFRSF1A CXCL9 BCL2 CD40 SOCS1 PMC2518081__F3 The pathways involved in polycystic kidney disease PC AVP CFTR PMC9577372__F7 Transforming growth factorB in tumour development MMP2 MMP9 PTEN PMC2892459__F4 Snapshots from the integrated macrophage pathway diagram HLA-DPA1 MAPK14 IFNB1 TNF IFNAR1 HLA-DOA PSMD13 PSMD7 TRIP12 TYK2 SIAH2 PSMD2 PSMD4 PSMD1 HK2 PSMC1 PSMD11 NHLRC1 PMC9201061__F2 Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies SNCA LRRK2 VPS13C PMC5228322__F1 Illustration of the Wnt signaling pathways NLK RHO PMC7408457__F2 Change in the profile of proteins and mRNAs of molecular factors in the primary tumor of the kidney and its metastatic sites INS PTEN MTOR PMC5996030__F2 Possible autophagy signaling pathways in traumatic brain injury (TBI) TLR4 MTOR NQO1 PMC5858516__F9 HyFS and the Hsp90/Akt/mTOR axis in lung cancer cells ULK1 ATG101 MTOR PMC7819896__F1 Cartoon representing the overview of the pathogenesis of COVID-19 and the potential activity of ruxolitinib JAK3 JAK1 PMC9931120__F11 The working model of how FMDV infection regulates host amino acid metabolism TSC2 SLC38A8 MTOR RHEB PMC2813054__F1 Changes in Akt signaling with differentiation of CD8+ T cells and co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1)-blocked highly differentiated CD8+ T cells KLRG1 PMC8094964__F10 DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication OTUD1 SMURF1 DDIT3 MAVS MX1 PMC3760546__F4 Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease TFPI PLG TF PMC7921671__F3 Cysteine metabolic circuitries: druggable targets in cancer RHOD CS PMC3760546__F6 Natural inhibitors of coagulation and anticoagulant drugs.TF, tissue factor; VKA, vitamin K antagonists; AT, antithrombin; APC, activated protein C; TFPI, tissue factor pathway inhibitor type-1 F2 APC TF PMC5346233__F2 Targeting Notch signalling pathway regulates angiogenesis in the pathological ovary NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC3533361__F1 GSK3 signaling in neural development DISC1 APC LRP5 LRP6 PTEN CDC42 PMC7921671__F5 Cysteine metabolic circuitries: druggable targets in cancer CTH HEL-S-64p CIC PMC7572318__F3 RIPLET is an essential E3 ligase for RIG-I signaling pathway TBK1 IRF3 MAVS PMC9144507__F2 Metformin and Cancer, an Ambiguanidous Relationship TSC2 IGF1R IGF1 MTOR PMC7402324__F2 WNT Signaling in Melanoma ROR2 RHO CDC42 PMC11379076__F2 MTORC1/2 signaling pathways TSC2 ULK1 TSC1 PTEN ULK2 DEPTOR RHEB MLST8 PMC7402324__F3 Proposed model of the crosstalk between canonical and non-canonical WNT-signaling in melanoma LRP5 CD44 LRP6 ROR2 CDH2 SIAH2 ARF6 BCL9 PMC11379076__F3 Interaction between mTOR pathway and HCC TSC2 ULK1 AFP TSC1 CXCR4 MYC YY1 ACLY LHB PMC7590211__F3 Opposing modulatory effects of TRIM25 and TRIM47 on TGFBeta-Smad signaling in the GI tract TRIM14 SMAD2 GSK3B SMAD4 PTEN TRIM27 MTOR TRIM44 TRIM47 TRIM25 PMC3942026__F2 Evolution of a Cellular Immune Response in Drosophila: A Phenotypic and Genomic Comparative Analysis DDC ALK EGFR TEP1 RAC1 MYD88 SPN TUB SP7 GCM2 PMC7590211__F4 TRIMs on proinflammatory STAT3 (A) and NFKB (B) signaling cascades in CRC VPS35 CCL21 RELB TRIM29 TRIM40 CXCL13 TRIM14 USP14 CCL19 SPHK1 JAK1 REL TRIM27 STAT3 PMC7590211__F2 Role of TRIMs in the control of p53 tumor-suppressor protein TRIM67 APC GSK3B MDM2 CD44 LRP6 TRIM28 CDH2 TRIM24 TRIM29 TRIM25 TRIM23 PMC7402324__F1 Simplified scheme of canonical WNT -signaling pathway ZNRF3 RNF43 APC GSK3B LRP5 LRP6 BCL9 PMC4485451__F1 BCR Signaling Pathway and Small Molecule Inhibitors of BCR Signaling BTK BASH LYN SYK PLCG2 MTOR CD19 PMC6873206__F4 YAP regulation by focal adhesion signaling NF2 SRC LATS1 RHO LATS2 PMC8641543__F1 Oncogenic factors regulate cancer cell metabolism MAX MYC MTOR PMC9570183__F1 Polyphenols as Potent Epigenetics Agents for Cancer APC DACT2 DNMT3B PMC8641543__F2 Inhibitors of glucose metabolism GPT HEL-S-133P PHGDH HK2 HEL-S-281 PMC3185539__F1 Summary of NSP1 inhibition of the innate immune response pathway TBK1 STAT1 STAT2 IRF3 TLR3 PMC7492639__F1 Ozone-mediated effects on intracellular pathways involved in cell injury and inflammation NLRP3 CGAS KEAP1 IL33 CCL2 CXCL12 IL25 PMC7402324__F6 Compounds and antibodies affecting WNT/Beta-catenin-signaling pathway that were investigated in melanoma (preclinical studies, except for LGK974, which is tested in the clinical trial NCT01351103) INA APC GSK3B LRP5 LRP6 TNKS DKK1 BCL9 PMC8831284__F3 Transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer’s disease risk TP53INP1 INCA1 ZNF232 NRF1 TRAPPC6A XYLT1 SNX32 EPHA1 NECTIN2 TAF6 YPEL3 PMC5427281__F8 Model depicting the mechanism of phagocyte priming by apoptotic cells RAC1 CRK PMC5059336__F3 miRNAs modulation in direct cardiac reprogramming TBX5 HAND2 GATA4 PMC2965861__F1 The AMPK pathway in relation to various molecules TSC2 STK11 MTOR FASN PMC3129516__F2 SIRT3 and Cancer: Tumor Promoter or Suppressor? NAMPT TRPM2 SIRT3 PMC7576205__F6 Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma RPS6KB1 IGF1R GAB2 GRB2 RPS6 MTOR AXL IRS1 RPTOR PMC8268497__F2 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development SUFU PTCH1 GLI3 SHH SMO PMC8268497__F3 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development SMAD4 ARHA MTOR PMC2703803__F1 The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target UROD UROS CPO PMC4435535__F1 Notch signaling as a novel regulator of metabolism PCK1 FASN STAT3 PMC4435535__F2 Notch signaling as a novel regulator of metabolism PRDM16 UCP1 PPARGC1A TG IL1B PMC10474053__F3 PI3K-AKT pathway and major upstream effectors in the signaling network TSC2 RICTOR BAD TSC1 GSK3B PTEN INPP4B RHEB PMC9556862__F1 Using Clustered Regularly Interspaced Short Palindromic Repeats gene editing to induce permanent expression of fetal hemoglobin in Beta-thalassemia and sickle cell disease: A comparative meta-analysis HBG2 HBG1 CHD4 KLF1 PMC4905314__F1 ER stress induced by oncogenic BRAF and modulation of basal autophagy in melanoma ATF4 EIF2A EIF4E MTOR TRAF2 PMC6396338__F6 Contrasting strategies for disrupting interferon (IFN)-mediated responses in hepatitis A virus (HAV) versus hepatitis E virus (HEV) infections STAT2 IRF3 TYK2 TLR3 MAVS PMC8891817__F18 Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling NLRP3 GCLM GCLC SMAD2 CXCL10 COL1A1 IL1B NQO1 PMC10474053__F6 Ca2+-mediated inhibition of membrane localization of PIP-binding proteins PLN TSC2 TSC1 GSK3B MCU PMC10474053__F5 Dysregulation of Ca2+ channels and pumps in metabolic diseases PLN TFEB MCU CRTC2 STIM1 PMC5834520__F1 Osteopontin in the progression of solid organ tumour DSPP DMP1 BAX PMC7699570__F2 Signaling targets of CO NLRP3 HMGB1 EGR1 PMC5834520__F2 Osteopontin in the progression of solid organ tumour EGF EGFR CD44 PTEN HIF1A PMC11660139__F8 Inhibition of miR-675 on TGFB signaling and OC progression SMAD2 SMAD4 PMC9355713__F3 Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism NLRP3 KEAP1 ATF4 PMC3100753__F4 Regulation of the estrogen signaling pathway inside the nucleus CTBP2 PELP1 PMC5441870__F3 Central metabolism of T RTCA NAPA NDP PMC4904747__F16 JAK STAT pathway STAT1 JAK1 PMC3272176__F1 Signal Transduction pathways downstream of activated HER family of receptors CCND1 PTEN MTOR PMC5805715__F4 The gene targets of miRNA identified by NGS in the AIS patients and their role in osteoblast and osteoclast differentiation depicted from KEGG and DIANA miRPath v3 CTSK RUNX2 BMP2 SMAD2 FGF2 APC GSK3B SMAD4 BMP4 NFIA SP7 SMAD1 DKFZp781O1323 PMC11018134__F7 FBL Promotes LPS-Induced Neuroinflammation by Activating the NFKB Signaling Pathway CD14 FBL MYD88 PMC9311231__F3 Metabolic assessment of tumors reveals alternative pathways for Trp catabolism CYP1B1 OGDHL PMC5984668__F1 STATus of STAT3 in Psoriatic Arthritis AHR CCR6 CCR10 CCR4 TNF STAT3 PMC6429030__F2 TLR2/IFN-λ3 protein-protein interaction was performed by using String software IL10 IFNL3 IL6ST IL6 IL4 STAT3 PMC8472352__F2 New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System PAK1 SRC ARHA RAC1 VAV2 PMC5756134__F2 An Unexpected Friend – ROS in Apoptosis-induced Compensatory Proliferation: implications for regeneration and cancer AIP PMC7962738__F2 Glutamine synthesis, nucleotide biosynthesis, and the pentose-phosphate pathway PFAS OMP UCK2 UMPS TYMP UCK1 GUK1 CMPK1 TK1 AK2 RRM1 ADSL RRM2 DTYMK TYMS PAICS CAD HEL107 RPE CTPS2 PNP PMC8811913__F6 Transition Toward Nitrogen Deprivation in Diatoms Requires Chloroplast Stand-By and Deep Metabolic Reshuffling NREP HEL107 PMC7962738__F1 Glycolysis, gluconeogenesis, glycogen metabolism, the hexosamine pathway, oxidative phosphorylation, and the TCA cycle CS PCK1 FBP1 PFKL HEL-S-87p PDK4 HEL-S-68p HEL-S-162eP HEL-S-49 PC OGT FH MPC1 MPC2 OGDH PGAM1 PMC7544648__F1 Mechanisms of alcohol-induced microglial eCIRP in promoting AD pathology NLRP3 HMGB1 TLR4 CDK5 JAK1 STAT3 PMC5403593__F3 Cartoon illustrating two independent parallel pathways in the post-mitosis G1 phase (G1-pm) in cell proliferation: MAPK and the Hippo pathways YAP1 EGFR LATS1 LATS2 PMC3422784__F5 Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system ME1 TPH1 CYP2C19 TPH2 NAT1 AANAT PMC3541667__F5 Hypothetic model explaining how KDM6 may contribute to definitive endoderm differentiation WNT3 DKK1 KDM6B PMC6958404__F1 Major Signalling Pathways Involved in Hepcidin Regulation ERFE TWSG1 BAMBI BMP6 EPO SMAD6 SMAD4 TMPRSS6 HFE POR TFR2 GDF15 JAK1 SMAD1 DKFZp781O1323 STAT3 PMC5403593__F2 Cell cycle phases and two examples of independent core pathways in the G1 stage YAP1 GIP PMC4846832__F6 Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury TLR4 IRAK1 MYD88 PMC7543703__F2 NSAIDs inhibit the synthesis of prostaglandins that protect against COVID-19 COX1 PMC8602059__F1 Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma TNIP2 TRADD OTUD7B RELB TRAF3 TRAF6 MYD88 MAP3K7IP1 TRAF5 CYLD VCP TRAF2 LTBR TAB3 PMC6850914__F1 Signal transduction pathways initiated by IL‐29 STAT2 NFATC1 IRF9 TYK2 JAK1 PMC6525179__F5 Gene expression and 14C fatty acids production in LC-PUFA synthesis pathway of liver between knockout (KO) and wildtype (WT) salmon CPM ELOVL4 ELOVL2 PMC6854382__F10 Study on the mechanism of the MPAPO promoting of corneal wound repair and axonal regeneration (A) MPAPO activates the classic Wnt/Beta-catenin signaling pathway through the PAC1 receptor BCL2 CDK4 CDK6 PMC8113731__F1 Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers GSK3B NEK2 PMC4508581__F4 Model illustrating the relationship between hypoxia, ER stress, and activation of the unfolded protein response ATF4 EIF2A XBP1 PMC2788213__F4 Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages SPN TLR3 MAVS PMC3536147__F3 Identification of Burkholderia cenocepacia Strain H111 Virulence Factors Using Nonmammalian Infection Hosts PURA PURB PMC9638168__F2 MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring TIMP3 MMP9 SMAD6 KLF4 ABO PPP2CA IL6ST TMEM9B STAT3 BAX PMC6185734__F9 Magnetic fields affects microtubules via EGFR and calcium pathways EGF MARCKS EGFR PMC7849182__F8 Schematic showing multiple signaling pathways of HSYA TLR4 F2 GRB2 MYD88 MTOR PMC8447736__F4 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 CASP3 MMP3 TNF MME FADD SELE ELL PMC12151402__F1 Proposed effect of CHEK2 loss of function on cytotoxic T-cell recruitment at different organizational levels CHEK2 CGAS ATM IRF3 ATR PMC8147131__F7 Metformin Dysregulates the Unfolded Protein Response and the WNT/Beta-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism ATF4 PMC11502721__F2 Intestinal homeostasis by microenvironment EGF RSPO3 RSPO1 AHR DGAT2 NRG1 TGFB1 MMP17 STAT3 PMC8447736__F5 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 NMU DAO SI CRH PMCH LEPR OXT POR MLX VIP PMC11502721__F3 Intestinal stem cells (ISCs) by glucose, fatty acid, and ketone body metabolism CPT1A MPC1 HK2 FASN PMC5627579__F3 Proximal tubule (PT) phosphate reabsorption FGF23 PTH XPR1 PMC4683444__F4 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity BAD NGF NTRK1 BCL2L1 CSF2RB BIRC2 TNFSF6 DFFA ATM IL3 BCL2 CSF2 AKT3 BAX PMC9562620__F9 Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NFKB signaling pathway COX2 TNF IL1B PMC5448108__F7 A proposed model for the regulation and function of two Grp78 genes in JH-stimulated locust vitellogenesis EIF2A SRC MCM7 PMC3837055__F1 Schematic view of kallistatin action in the canonical Wnt pathway APC GSK3B LRP5 LRP6 PMC5239457__F7 EIF2A serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress ATF4 EIF2A LATS1 WWP1 LATS2 FOXO1 PMC10215824__F3 Obesity-altered adiponiche and tumour development: some novel proposed mechanisms in mature adipocytes and precursor cells VEGFC CD34 TNF MTOR TF PMC9647059__F1 Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system NLRP3 IL16 SOCS3 EDNRB LIF EDN2 IL1R1 CCL2 MYD88 SOCS1 STAT3 PMC3192015__F1 Mammalian target of rapamycin, Akt, and phosphatidylinositol 3-kinase signaling TSC2 RICTOR EIF4E RHEB MLST8 PMC2684375__F1 Factors involved in the regulation of corporal smooth muscle tone GC CNP RHO PMC4980583__F5 Thumbnail image of MAPK signalling pathway NLK MAX FLNA TRAF6 TNF PMC5100880__F6 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer BAD CDK2 MDM2 BCL2 PTEN PMC5345976__F10 Scheme summarizing the protective effects of Xn on LPS-induced acute lung injury via activation of the AMPK/GSK3Beta-Nrf2 axis NLRP3 GSK3B TXNIP IL1B PMC5100880__F7 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer BAD CDK2 MDM2 BCL2 PTEN PMC9301183__F1 NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes NLRP3 ACE2 IL1B GSDMD PMC6030217__F1 Role of NUAK1 in anti-oxidant signalling NUAK1 KEAP1 GSK3B MYC PMC8018950__F3 Top regulatory effect predicted by Ingenuity Pathway Analysis within Fayoumis at 6 dpi comparison MAPK9 IRF8 FOS ABCG1 IL33 NFIL3 FOXP3 PMC5095680__F4 Impact of miR-140 overexpression on proteins involved in the NFKB signaling pathway ZFP91 ADAMTS4 ADAMTS5 IL6 IL1B PMC5382464__F1 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the FoxO signalling pathway (KEGG ecb04068) EGF ATG12 EGFR INS SMAD4 PTEN INSR NLK ATM CDK2 MDM2 IL7R SIPA1 BNIP3 SKP2 STAT3 PMC5784915__F6 Inferring hidden causal relations between cancer and normal networks BAD BTRC HEL-S-1 MAPK3 GSK3B PRKAA1 BCL2L1 MTOR RPTOR MAPK1 PRKDC PRKAG1 EIF4B YWHAG PRKAB1 PRKAA2 MAP3K7 RBX1 FBXW11 HTRA2 RHEB CASP3 RICTOR MAPK6 RPS6KA1 RPS6KB2 DUSP16 STK11 BCL2 BNIP3 HEL-S-93 RPS6KA2 CYCS CAMKK2 USP1 PMC9617413__F4 Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus DAP SDHB PMC9233553__F2 Coronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15) ISG15 TYK2 IFNG USP18 PMC5784915__F7 Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks CCNA2 FOXM1 BLM CDKN2C DBF4 DTL FEN1 ECT2 CDCA7 RRM2 KNTC2 CCNB1 CDCA3 CDC2 VRK1 CEP55 CDC25B AURKA CDCA8 AURKB SPAG5 MCM2 HEL164 CKAP2 PCNA ESPL1 PMC10845297__F3 Fibroblasts of metastatic organ in PMN formation FAP CCR8 TNFAIP3 CCL1 PMC4745841__F7 Functional interpretation of the IL-6 gene signature and its relationship to the three main downstream pathways of IL-6.Notes: The 17 genes are part of the Jak-STAT IL-6 downstream pathway CFB IFITM3 EBP IFITM2 LCN2 AKR1C1 S100A9 AKR1C2 SERPINA3 S100A7 IFITM1 CEBPD TMC5 GBP2 S100A8 STAT3 PMC6099083__F5 Tumor Epigenetically Upregulated Genes (EUG) in Epstein-Barr Virus Infection pathway IL10 TBP MDM2 CD44 TRAF6 CD40 IRF3 JAK3 NEDD4 IFNG STAT3 PMC10085880__F7 In silico identification of potential miRNAs -mRNA inflammatory networks implicated in the pathogenesis of COVID-19 IL10 NLRP3 ADAR STAT2 IRF9 TRAF3 SYK IRF3 TLR3 PMC9265283__F5A Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer HEL-S-165mP CCT4 HEL-S-30 EEF1A1 DES HEL107 KRT10 ACTG1 HEL-S-68p PMC3826456__F2 Diagram of PI3K/Akt and Ras/Raf pathway (see text for details) TSC2 TSC1 EGFR IRS1 RHEB PMC2670830__F4 Signaling in pterygium SPARC EGR1 CSTA USF1 FOS BTG2 JUN SP3 APOE TAGLN PMC2932530__F9 Redox regulation of the PI3K/Akt signaling pathway PI3 BAD PTEN PMC2733082__F2 InterferonG signaling pathway and mutations in its components found in human uterine leiomyosarcoma STAT1 JAK1 IRF-1 PMC8739172__F4 Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation RICTOR GHB2 GRB2 RHO SLC3A2 TNF MTOR PMC6836530__F8 Schematic diagram of the molecular mechanisms underlying NOTCH2-regulated EMT NOTCH2 TRAF6 PMC8465509__F2 Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics EGFR SRC MTOR STAT3 BAX PMC9399684__F2 Modulation of ion channels in cancer chemo-resistance BAD SOX2 TRPV2 MDM2 KLF4 CD44 GSC BAX PMC2525561__F4 Schematic diagram of in vivo n3 VLC-PUFA biosynthetic pathway mediated by ELOVL4 and other ELO families [modified after Suh and Clandinin ()] ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC5485329__F3 AMPK and mTOR pathway by Sestrins TSC2 ULK1 TSC1 NOX4 MTOR PMC5382464__F2 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the PI3K-Akt signalling pathway (KEGG ecb04151) BAD MEI1 CDC37 PTEN RAC1 EIF4E MTOR RHEB RXRA TSC2 PI3 BCR MDM2 SYK RBL2 CD19 PMC6593125__F1 T-cell receptor (TCR) signaling CSK LCK GRB2 LAT PMC4741479__F4 Radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas MYB VEGFA WT1 DNMT3B CDK6 SMC1A FLT1 KDR CDKN1A ATM MDM2 CCND1 BCL2 CD40LG CDK4 MCL1 SP1 PMC7310461__F4 Alterations in TCR signaling pathway PIK3CD PIK3R1 PPP3CA PPP3CC GSK3B NRAS TEC PDPK1 NCK1 IFNG VAV3 CD8B FYN BCL10 CSF2 ICOS PRKCQ SOS2 FOS VAV1 MAP3K7 CTLA4 TNF HRAS PIK3R3 PAK1 MAPK13 PPP3R1 GRB2 LAT NFKBIE CDC42 PLCG1 IKBKG CHUK PPP3R2 PAK4 LCP2 IL2 CD40LG CDK4 PTPN6 IL4 CD3G JUN IL10 CD3D NFATC1 MAP2K2 CD8A IL5 NFATC3 IKBKB PTPRC CARD11 NFKBIA NFKBIB NFATC2 NFKB1 LCK RELA GRAP2 ZAP70 PIK3CA RAF1 VAV2 PIK3R2 PDCD1 PMC7310461__F5 Alterations in the BCR signaling pathway PIK3CD PIK3R1 PPP3CC GSK3B PLCG2 IFITM1 DAPP1 LILRB5 VAV3 BCL10 LILRA4 FCGR2B SOS2 FOS HRAS PIK3R3 RAC3 PRKCB LILRA6 PPP3R1 LILRA1 LILRA3 GRB2 LILRA2 NFKBIE IKBKG CHUK PPP3R2 CD81 NPAT BTK BASH LILRB2 LILRB4 JUN CD19 INPPL1 NFATC1 RAC1 CD79B CD79A NFATC3 IKBKB CARD11 NFKBIA NFKBIB NFATC2 CD72 RASGRP3 NFKB1 RELA CD22 LYN LILRB1 PIK3CA SYK RAF1 CR2 SOS1 VAV2 PIK3R2 PMC11958781__F9 Mechanistic diagram illustrates that KLF6 cooperates with FOSL2 to promote H3K23su levels and enhance 5-FU resistance in HCT15-FR cells SEMA3C RAC1 FOSL2 PMC4077717__F1 Overview of the general innate immune response to viral infection PML TBK1 CGAS RSAD2 IRF7 IRF9 BST2 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 IFITM1 IL10RB MX1 STAT1 ISG15 CH25H OAS1 TYK2 JAK1 MAVS IFI16 IFIT1 PMC8555304__F3 Chemoprotective and chemosensitizing effects of apigenin on cancer therapy BAD MEI1 KEAP1 TNF BAX PMC1885990__F1 Scheme depicting a molecular pathway by which cell-cycle-related molecules promote cell death in neurons in development and disease E2F4 SUV39H1 CDK4 HDAC1 PMC3096978__F4 Functional network connections between HRneg/Tneg signature genes IL10 HAPLN1 RGS4 ACTA1 TNF EEF1G IFNG EXOC7 CXCL13 RPS28 CLIC5 CCR7 MAPK1 MAPK11 SP1 STAT3 CCL3 PMC7310461__F3 Alterations in SLE signaling pathway based on calculated final parameters IFNG C9 C7 HLA-DPA1 HLA-DOB TNF HLA-DRB1 HLA-DRB5 C8G H2AC14 SNRPD1 HIST1H2AB HIST1H2AK HLA-DRB4 H2AJ H2BC14 HLA-DMB H2BC15 H2BC11 HIST1H2BE MACROH2A2 HEL-S-62p H2BW1 FCGR1A H2BW2 C4B_2 H2BC9 H2AZ1 FCGR2A H4C7 H2BC8 H3F3B H2BC3 HLA-DQB1 H3-5 C4A HLA-DMA HLA-DRB3 ELANE CD40LG C1S IL10 H2BC12 HLA-DOA CTSG C8A FCGR3A HLA-DPB1 SNRPB H3C15 H3C8 C6 CD40 H2AC21 CD80 HLA-DQA2 H4C9 PMC6687721__F7 The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress CASP3 ATF4 EIF2A CASP9 BAX PMC2151384__F2 CON and NR samples; black/white boxes denote genes not detected on the human genechip with baboon RNA generated probe TSC2 RICTOR TSC1 LEPR EIF4E HIF1A MTOR EIF4B RHEB STAT3 PMC9090500__F7 Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes NLRP3 IL18 TNFAIP3 PMC9362342__F1 Cellular senescence and the SASP CXCL1 ATM FOXO3A MDM2 CDK4 BMI1 ETS2 MTOR ATR GATA4 PMC3326643__F2 Targeting Mnks for Cancer Therapy NF1 TSC2 TSC1 ELF3 PTEN EIF4E EIF4B IRS1 RHEB PMC8932957__F2 Conserved nutrient-sensing response pathways in worms, flies and mammals EGR1 TFEB IGF1 MYC PMC8052137__F6 Underlying Molecular Mechanisms Involved in Traditional Chinese Medicine Smilax china L. for the Treatment of Pelvic Inflammatory Disease PLAUR MPO PGR PTGS2 MMP9 ALB LCN2 SLC22A6 HSPD1 TNF MMP2 CYP3A4 IL2 ABCC2 ABCB1 STAT3 PMC12029909__F5 Screening for maps of metabolic pathways involved in key differentially expressed metabolites APP CIT MAL PMC6718556__F5 Several metabolic mechanisms may provide an advantage to Tregs in the tumor microenvironment GCK CD36 PMC6533481__F7 The molecular mechanism involved lncRNA MEG3 affecting the fraction healing of mice after tibia fracture RUNX2 GSK3B EZH2 WNT10B COL10A1 PMC8554124__F9 Systematic Review of Transcriptional Dysregulation in Huntington’s Disease Studied by RNA Sequencing HEL-S-102 DNAJB1 HSPA1A PMC9656133__F6A Integrated Multi-Omic Characterization of the Detachment Process of Adherent Vero Cells with Animal-Based and Animal-Origin-Free Enzymes LAP3 PMC2743781__F3 NAD biosynthetic pathways from nicotinamde and nicotinic acid in yeast, invertebrates, and mammals NAMPT NMNAT1 NMNAT2 NMNAT3 PMC6549095__F7 Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NFKB expression MMP2 MMP9 AXL PMC8451004__F4 Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer MYB TSC2 BAD BCR MDM2 SYK PTEN RAC1 RBL2 CD19 PMC10741662__F1 WNT/Beta-catenin signaling pathway APC LRP5 LRP6 APCDD1 PMC3546740__F2 Simplified schematic overview of the biosynthesis of the main secondary metabolites stored and/or secreted by tomato glandular trichome cells STS IPP HEL-S-5 PMC2889494__F3 Protein components of the pheromone response network constructed by the PCST approach SWI5 ORC6 CCR4 ARAP1 ACE2 TF PMC8894239__F3 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment GCK PTEN TLR1 TGFB1 POLI FOXP3 PMC9311918__F1 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases TSC2 PINK1 TSC1 TFEB ATF4 BNIP3L ATG14 RHEB BAX PMC8894239__F1 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment TSC2 TSC1 FOXO3A PTEN DEPTOR RHEB PMC9311918__F3 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases MTOR DEPTOR IRS1 MLST8 PMC11668900__F1 Mechanisms affecting gastric epithelial cell plasticity PTCH2 KIF7 ARHH SMAD2 APC LRP5 MYC SNAI2 SMAD4 LRP6 DKK1 DLL3 SUFU PTCH1 CXCR4 GLI3 DLL4 SMO CDH2 CDC42 CD24 PMC6829565__F6 Schematic diagram depicting the MAPK/ELK1 signaling pathway linking Ang II-RBM20-titin splicing RBM20 TTN PMC8583510__F5 Mitochondria as a Cellular Hub in Infection and Inflammation TANK DHX58 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 GSDMD NLRP3 TLR8 IL18 TLR7 TLR4 ECSIT MAVS PMC3127159__F2 TPO signaling pathway BCL2 TPO PMC12050339__F7 Molecular pathways involved in the mechanism of mLV injury VEGFC XLKD1 CX3CR1 PIEZO1 EGFR PROX1 FOXC2 PMC6298397__F3 Central metabolic pathway of representative carbon sources in model iZBM1060 (detailed information on enzyme information and reactions are presented in Supplementary Table ) ME2 KDR GIP CIT MAL PMC5932555__F2 Design and application of scaffold RNAs controlling both genomic target sequence and regulatory function MXI1 CP PMC9687450__F5 UPLC-QTOF/MS Metabolomics and Biochemical Assays Reveal Changes in Hepatic Nutrition and Energy Metabolism during Sexual Maturation in Female Rainbow Trout (Oncorhynchus mykiss) PC BIK TG PMC8582418__F3 Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment FASN GLS PMC4110160__F1 Differential LSEC Signalling in Models of Acute or Chronic Injury FGFR1 HGF CXCR4 PMC3880197__F2 Reactive oxygen species in cancer SRC PTEN RAC1 PMC11056316__F9 Schematic illustration outlining the mechanism by which PIN operates during osteoclastogenesis NFATC1 MMP9 TRAF6 ACP5 RAC1 ATP6V0D2 PMC8623999__F7 Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGFB1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction FGF21 MMP2 SMAD2 MMP9 PMC7843416__F1 Type I interferonopathy-associated genes are involved in the sensing and metabolism of viral RNA RNASET2 TREX1 PMC2810486__F1 The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections COX2 IL16 TLR4 TRAF3 IL6 MYD88 TIRAP PMC8395241__F7 Analysis of PPARG Signaling Activity in Psoriasis RORC MAP3K1 FOS TICAM2 EGFR IL17F MAP3K7 TRAF6 MYD88 PDPK1 TICAM1 TSC2 MAP2K1 IL17A SRC STK11 IL-21 PPARG JUN STAT3 PMC5497685__F1 Ca2+ regulates different steps of autophagy ULK1 PI3 TFEB HEL-S-11 TRPM2 MTOR PMC4096794__F8 Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype FOXA1 TFAP2C TFAP2A PMC7689098__F1 KLF9 regulates cAMP signaling pathway genes in HT22 cells TIAM1 RAP1A AMH FOS ARHA RHO RAF1 BDNF JUN VAV2 PMC7689098__F2 KLF13 regulates cAMP signaling pathway genes in HT22 cells TIAM1 PAK1 RAP1A AMH FOS ARHA RHO RAF1 BDNF JUN VAV2 PMC3720582__F1 Comprehensive Hedgehog Signaling Pathway HHIP DHH BOC NUMB PTCH2 IHH RUNX3 CCND2 SUFU PTCH1 GLI3 NOTCH1 SHH SMO SKI TCF4 ITCH PMC3720582__F2 Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer HHIP DHH BOC NUMB PTCH2 IHH RUNX3 SNAI1 GAS1 SUFU PTCH1 SHH BCL2 SMO SKI TCF4 ITCH PMC6038002__F10 Tim‐3 exacerbates kidney ischaemia/reperfusion injury through the TLR‐4/NF‐KB signalling pathway and an NLR‐C4 inflammasome activation TLR4 NLRC4 TNF PMC7689098__F9 Proposed model for the repressive actions of KLF9 and KLF13 on cAMP-dependent neurite-outgrowth RAP1A KLF13 KLF9 RAF1 PMC4121837__F6 Proposed model for 18-5p–mediated inhibition of viral reactivation through the MAPK signal transduction pathway BCR MAP3K2 RAC1 PMC8123704__F5 Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway IRAK1 IRAK4 MYD88 IL1B PMC3032466__F11 Expression of cell cycle genes in wild-type (WT) and CKX-4 tubers after GA3-mediated tuber sprouting CDC20 WEE1 APC PMC8305988__F4 Personalized Genomics Approach of the Prostate Cancer CHUK BAD CDKN1B MMP9 EGFR CREB1 PTEN MTOR NFKBIA CREBBP CDKN1A MDM2 CASP9 AKT3 PMC3679038__F7 Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells KEAP1 MAFK GCLC PMC9133881__F5 miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network EDARADD EDAR PC HEL-S-30 BMP2 CIT TNLG7C DKK4 FGF20 BMP4 PMC6566851__F5 Effect of butyrate on the Wnt signaling pathway Butyrate can increase Wnt1/2/3 expression, which bind to their receptor Fzd to activate Wnt signaling pathway WNT3 WNT1 PMC9005359__F5 Risk-Related Genes and Associated Signaling Pathways of Gastrointestinal Stromal Tumors TRPV4 HLA-G HIPK2 ATM MRC2 ATR GATA4 HEL-S-69p PMC12090635__F2 EMT and Notch signaling pathway TSPAN5 RNF187 ACTL6A NOTCH1 ADAM10 C6orf79 KIAA1217 STAT3 PMC6566851__F8 Crosstalk of signaling pathways under butyrate influence RAC1 STAT3 BAX PMC12090635__F1 Composition and activation of Notch signaling pathway DLL4 JAG2 DLL3 PMC4850467__F1 Different compounds in cigarette smoke regulate EMT AHR SRC PAH PMC8399643__F3 Regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease SP2 ATF4 SP1 XBP1 PMC2914561__F1 Translation control of gene expression AGO1 EIF2A EIF4E MTOR PMC6474359__F2 IL-17 family of cytokines in health and disease BAD TRAF5 TRAF6 SYK CAD TRAF2 IL17RC ARID5A PMC9658645__F3 Monocyte, a Maestro in the Tumor Microenvironment (TME) of Breast Cancer SPARC EGF PITPNM3 VEGFA CXCL17 CCL18 CSF1 PMC6679138__F3 Proposed model for the cellular response to complex DNA damage (CDD) induced by proton beam therapy (PBT) in chromatin MSL2 RNF20 PMC9062296__F8 Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion of NDP TSPAN12 LRP5 FZD4 PMC8569703__F1 Contextual Essentiality of Mitochondrial Genes in Cancer CS PTPMT1 BCL2L1 UQCRFS1 PC FAM36A TFB2M MRPS6 LETM1 PPA2 HEL-S-44 DUT TFAM SDHC CHCHD4 FES FXN ISCU TRIAP1 SLC25A3 NDUFA2 COQ2 PRODH GFER TOMM40 DHODH CYCS PMC8299562__F2 Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies SOCS3 NPY FGF19 LEPR EIF4E MTOR STAT3 CAMKK2 PMC6108178__F3 Primary myelofibrosis based on results obtained in animal models TPO MPL PMC5476263__F2 Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes FEN1 FAN1 FANCD2 ATM BLM HLTF ATR PMC4890621__F2 BIOPROSTHETIC HEART VALVES OF THE FUTURE ICAM2 CD34 CRP CD44 PIGS PMC11952772__F2 Lactobacillus regulate skeletal muscle pathways through short-chain fatty acids IGF1 FFAR3 FFAR2 MTOR PMC11952772__F1 Possible mechanism of Lactobacillus alleviating sarcopenia TLR4 IMPACT PMC4861839__F1 Inositide signaling pathway and target agents used to treat gastric cancer and colorectal cancer TSC2 RICTOR TSC1 PTEN MTOR PMC6463672__F8 LINC01354 and Wnt/beta-catenin signaling pathway MMP7 HNRNPD TCF4 PMC7903614__F6 Primary paracrine and autocrine signalling contributes to cholesteatoma pathogenesis upon activation of the TLR4 pathway EREG EGF TLR4 HGF CXCL5 IGF2 IL1B PMC8353874__F2 Triple-negative breast cancer: understanding Wnt signaling in drug resistance MUC1 EGF TWIST2 TWIST1 EGFR GRB2 GATA6 PTEN MTOR STAT3 PMC8353874__F1 Triple-negative breast cancer: understanding Wnt signaling in drug resistance DAAM1 APC EGFR GSK3B LRP5 CD44 CCND1 LRP6 ARHA CDC42 PMC10037512__F6 Mechanism of STX5 involvement in HCC metastasis CAD MTOR STX5A PMC6027047__F1 Metabolic activation of aristolochic acid I (AA-I), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 5-methylchrysene, and tamoxifen are shown as prototypes of procarcinogens POR PHIP NQO1 PMC5562846__F1 Simplified scheme of chromatin changes in response to double-strand break (DSB) occurrence highlighting a central role of the ATM kinase RNF168 RNF8 ATM MDC1 RAD50 MRE11A PMC8862475__F7 Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas MTOR CIT HEL-S-5 PMC7803748__F4 Muscle atrophy and hypertrophy: implications in health and disease TRADD TRAF6 TRAF2 IRS1 PMC7803748__F1 Muscle atrophy and hypertrophy: implications in health and disease ULK1 MTOR IRS1 RHEB TSC2 RICTOR TSC1 IGF1 USP14 GABARAPL1 FBXO31 PSME4 BNIP3 UBE4B PSMD11 PMC7803748__F2 Muscle atrophy and hypertrophy: implications in health and disease SMAD2 SMAD6 SMAD4 BMP7 MTOR GDF11 SMAD1 DKFZp781O1323 PMC8024302__F4 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia NLRP3 TLR9 MYD88 IL1B PMC8024302__F5 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia MFN2 ULK1 MFF HIF1A PMC2952980__F1 Multifactorial pathway leading to gastric carcinoma TLR4 SIM1 IL1B PMC3548018__F2 Integrated scheme for MIF expression, signal transduction and regulation of glucocorticoid immunosuppression and cell survival MAPKAPK2 CXCR4 CD44 SRC IL8RB TNF CD74 PMC8533092__F1 Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges PNPLA3 TM6SF2 IL33 SREBF2 IL1B PMC8851862__F3 Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat ATM CDK2 SSB RAD51 CDK4 NUDT16L1 CDC2 ATR NEK11 DNA2 CDK6 PMC5643752__F1 Schematic representation of Nrf2 and Keap1 protein domains MAF KEAP1 PMC9634729__F1 Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma SSB XPC MSH3 MSH2 BRCA1 PMC5643752__F2 Hinge-latch model of Nrf2 MAF KEAP1 JUN NQO1 PMC4905289__F2 TGFB signaling HEL-S-89n CRIPTO TGFBR2 SMAD4 TGFBR3 MSI2 PMC5629438__F3 Intracellular and Extracellular mode of Toll‐like receptor (TLR) signalling pathways: signalling heterogeneity in TLR pathways arises from the differential recognition of pathogen‐associated molecular patterns (PAMPs) by different TLRs TBK1 CD14 TLR5 TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 TIRAP TAB3 MAL PMC4086146__F1 Schematic model of mammalian heme homeostasis FECH BACH1 PMC11755879__F1 Molecular mechanisms of NLRC5 regulation of NFKB and type I IFN pathways and MHC I gene expression TBK1 STAT1 IRF3 JAK1 RFXANK IRF-1 MAVS PMC11755879__F2 Functions of NLRC5-dependent domains CCND1 IRF3 SIN3A SPN HEL-S-104 STAT3 PMC2900209__F6 Inflammation Stages in the Acute Lung Injury in Mice MAP2K4 RASA2 CREB1 TRAF6 MAP2K2 MAP2K3 TNF MAP2K6 DDIT3 MAP4K1 PAK1 FGFR1 CRTAP MAP2K1 AHSA1 MAP3K2 NFKB1 GRB2 RAF1 TRAF2 JUN PMC11755879__F3 NLRC5 in cancer LMX1A VEGFA PMC3944192__F1 Kidney Regeneration: Common Themes From the Embryo to the Adult PAX2 WNT4 BMP2 SALL1 WNT9B LHX1 BMP7 WNT7B BMP4 PAX8 PMC9614744__F7 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D EGF BAD BTC MYC GRB2 SHE JUN CBL PMC9614744__F8 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D CD14 NLK DAO MAX GRB2 TRAF6 ECSIT GAL TRAF2 APMAP ASIC2 PMC6314413__F3 Representative Wzx/Wzy-dependent capsular polysaccharide (CPS) biosynthesis pathway in the group B streptococcal serotype III ACCS GAL SCOC PMC6916502__F7 Proposed mechanisms for panx1 regulating ferroptosis in renal IR injury FTH1 PANX1 PMC9136161__F2 Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases STX4A SEC22B STX3A SNAP29 SNAP23 PMC11625861__F1 The HS biosynthetic pathway HS2ST1 EXT2 XYLT1 EXT1 GLCE B3GALT6 PMC11765393__F1 Insulin signaling pathway in a healthy human brain NRF1 GRB2 SHE MTOR IRS1 PMC9084498__F1 Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity CS HEL-S-5 PMC4807882__F3 A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer CXCR1 EGF NR1i1 GRB2 SRC CTLA4 MTOR PMC9181737__F2 Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery IKBKB TLR4 PMC9019758__F9 Bushen Culuan Decoction Ameliorates Premature Ovarian Insufficiency by Acting on the Nrf2/ARE Signaling Pathway to Alleviate Oxidative Stress MAF CLU BACH1 MAL PMC7969947__F3 Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition ALK TFG MTOR PMC8864737__F3 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization TH PMC4280296__F1 Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement MTR PMC6014344__F4 Cross-link between TGFB pathway, Wnt pathway, and ILK pathway SMAD2 APC SMAD4 TGFB1 PMC7976506__AF1 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease CIT PMC6014344__F2 Molecular mechanisms involved in induction and progression of podocyte EMT caused by hyperglycemia HEL-S-28 CAD PMC6014344__F3 TGFB/Smad classic pathway SMAD2 SMURF2 SMAD4 SKI PMC8864737__F2 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization HEL-S-26 AIP AMH PCK1 FBP1 PDHA1 ART1 FAT1 FAT3 HEL-S-68p PMC8107416__F1 DHODH and cancer: promising prospects to be explored OMP UMPS CAD DHODH PMC7969441__F3 Telomere signaling pathway linking DNA damage response (DDR) and activation of ATM/ATR kinase, cycle arrest, and initiation of DNA damage ATM ATR PMC4705829__F1 Signaling crosstalk between the mTOR complexes EEF2K TBC1D7 RAC1 EIF4E MTOR DEPTOR IRS1 RHEB MLST8 TSC2 TTI1 RICTOR TSC1 ELF3 MAF1 EIF4B POLI PMC3827841__F6 TGFB and NOTCH activation in AoSMCs stimulated with P SMAD2 SMAD4 HES1 PMC9569545__F1 Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing MFN1 MFN2 SSB PMC3827841__F3 Protein-protein interaction network and SPIA analysis of the 28 up-regulated genes related to positive regulation of cell proliferation and 21 down- regulated genes related to negative control of cell proliferation PML CTTNBP2 IL34 TGFBR1 SOX4 PRKCA PDGFA NGFR TGFBR3 ADM SCG2 NOTCH4 COL18A1 TBX2 BMP2 IGF2 FGFR3 ATF3 HBEGF TNLG2B HEY2 TNFRSF8 KLF4 ADA BDKRB2 SPHK1 BDNF TGFB1 PMC8365418__F10 Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage RET NEUROD6 ASCL1 NGFR NEUROD1 DLX5 PMC7298859__F7 TNFA/TNFR2 immune checkpoint signaling pathway could be used to target different aspects of tumor cells micro environment CD80 TNF PMC1235815__F7 Possible ATM pathways contributing to polyomavirus replication (see Discussion) ATM CDK2 MDM2 BRCA1 PMC3796519__F6 IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner STAT1 TLR3 STAT3 PMC3879613__F7 Biological functions regulated by miR-378 and miR-378* HEL-S-133P HEL-S-69p PMC9292677__F1 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis SPHK1 LPP SPHK2 PMC9292677__F2 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis HGF SPHK1 TRAF2 LMO2 PHB2 TRIO PMC9292677__F4 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis COX2 S1PR2 NFATC1 GSK3B LRP5 S1PR1 S1PR3 SPHK1 SPNS2 PMC5167996__F7 A model on how BLM complex promotes FANCM recruitment to stalled forks and replication traverse of ICLs BLM FANCM ATR PMC8201988__F5 Integrative Ranking of Enhancer Networks Facilitates the Discovery of Epigenetic Markers in Cancer EGF IGF1 DAO POLK EGFR PROC MDM2 CDK4 BAX PMC3077922__F3 Gene expression changes in response to zebularine therapy in vivo NCBP1 UXT SIN3B CAST IMPACT TMEM126A MYC RPN2 ANXA4 PHLDA1 MGST3 CTNNA1 LSM1 LSM3 PCGF2 TRIP12 RPL29 CEPT1 TYMS HNRNPH1 PTMA SRPK2 MYOC PHB2 PMC5226641__F1 Dysregulation of MicroRNA Biogenesis Machinery in Cancer DGCR8 DROSHA RAN XPO5 PMC6606799__F2 Temporal changes in the transcriptome related to the central metabolic pathway in a synchronized C FBP1 MAL PMC7461813__F2 TM4SF1 promotes the development and migration of cancer cells DDR1 SOX2 ADAM23 VEGFA DVL2 CDH2 MTOR TM4SF1 PCNA STAT3 BAX PMC7409344__F3 eIF4B can stimulate eIF4A EIF4E EIF4B PMC7312067__F1 MITOL regulates both RIG-I-like receptor (RLR) pathway and Toll-like receptor (TLR) pathway; (B) Relativity between MITOL and cell death signaling in cancer cells TANK IRAK1 MYD88 MAVS PMC7409344__F2 eIF3 consists of the conserved eIF3a, eIF3b, eiF3c and the less conserved eIF3e, eIF3f, eIF3h subunits EIF3E EIF3F EIF3A EIF3B EIF3S3 MTOR EIF3C PMC4320988__F1 Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis TWIST1 ZEB2 CD44 SMAD4 IL6 JAK1 DDR2 IL6R STAT3 PMC6062828__F2 Presynaptic homeostatic functions of calcineurin (CaN) HEL-S-11 CDK5 PMC9356669__F6 Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19 NLRP3 TLR8 TLR7 TLR4 IRF7 IRF9 TRAF6 IRF3 ACE2 MAVS TMPRSS2 PMC8555221__F2 Systematic review of proteomic biomarkers in oral squamous cell cancer CCND1 CDK4 CDK6 PMC8903576__F11 Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism ATF4 EIF2A MTOR STAT3 BAX PMC6260243__F4 JAK1 may be the target molecule of (+)-terrein in the IL-6 signaling pathway in HGFs GRB2 VEGFA CSF1 STAT3 PMC3681875__F7 Novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair CDK2 CDT1 BRCA1 PMC8487948__F1 WNT signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 PORCN GPR49 LGR6 BCL9 WLS PMC6056413__F7 Schematic diagram showing proposed pathway through which cyclic mechanical loading regulates primary cilia expression to control tendon matrix turnover SET PMC5290160__F7 MYC-mediated mRNA cap methylation of Wnt/Beta-catenin signaling pathway transcripts MAX GSK3B MYC RNMT TRRAP CDK7 POLI PMC10850749__S1 Garcinone C attenuates RANKL-induced osteoclast differentiation and oxidative stress by activating Nrf2/HO-1 and inhibiting the NF-kB signaling pathway CTSK NFATC1 MMP9 PMC8487948__F4 Targeting the WNT pathway- inhibitors in clinical trial ZNRF3 RNF43 APC LRP5 LRP6 PORCN TNKS GPR49 LGR6 BCL9 WLS PMC8870278__F3 Mitophagy in Viral Infection NLRP3 TUFM DKFZp686F0183 MAVS PMC5343325__F5 Jak-STAT signaling pathway PIM1 EPO IL6 CBL PMC5343325__F3 P53 signaling pathway CASP3 TSC2 BAD ATM CDK2 MYC PTEN ATR CYRIA PMC5343325__F4 TGFB signaling pathway BAMBI FST NODAL SMAD4 SKP1 ARHA THBS1 RBX1 LTBP1 SMAD1 IFNG PMC3362516__F1 Mitochondrial Ca2+ influx and efflux mechanisms MFN2 MICU1 LETM1 MCU PMC5343325__F2 MAPK signaling pathway NF1 CD14 NLK MOS MAX FLNA EVL ECSIT TNF BDNF TRAF2 PMC4590606__F13 Model of T3-induced hepatic mitophagy ULK1 SQSTM1 PRKAA1 MTOR NR1A2 FOXO1 RPTOR CAMKK2 PMC7462335__F5 Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine EGF HEL-S-28 FGF2 EGFR GSK3B PTEN HIF1A MTOR APP CCND1 ARC TGFB1 STAT3 TERT BAX PMC6620530__F2 Highlights of tumor metabolism PDC DHFR MYC LDLR TYMS ACSS2 HMGCR HK2 FASN HEL-S-162eP GLS PMC7576358__F9 Mechanism of forsythin protecting RPE cells from apoptosis induced by hydrogen peroxide through the Nrf2 signaling pathway KEAP1 NQO1 BAX PMC6279568__F5 Resistance to MET and MET/MAPK/ERK inhibition in DFCI358 IGF1R EGFR SHE HRAS IRS1 STAT3 PMC7501145__F1 Nutrient Transporters by Metabolic and Environmental Stresses APC SIM1 SIM2 PMC7097199__F2 Signal transduction by SUMO GRB2 SMO JUN PMC4756895__F1 Metabolic pathways – (a) Metabolic pathway of phenylalanine; (b) Pathway of urea cycle OTC NAGS ASL PMC4078227__F2 Hedgehog signal pathway SUFU GLI3 SHH SMO PMC1948012__F10 Action for AICAR in human leukemia ALL cells TSC2 TSC1 PTEN MTOR RHEB PMC9382309__F3 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression MDM2 DDX5 PMC4370503__F1 Vitamin D Receptor Cdx-2 Polymorphism and Premenopausal Breast Cancer Risk in Southern Pakistani Patients VIT NR1i1 CDX2 RXRA PMC9489161__F2 Immunological and toxicological risk assessment of e-cigarettes IL6 IL1B PMC7645269__F8 Fibrogenesis during skeletal muscle atrophy SMAD2 NOX4 TRAF4 PMC3323758__F4 DNA base excision repair: A mechanism of trinucleotide repeat expansion FEN1 TNR OGG1 PMC8534645__F2 Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities SIRT6 NR1C1 SIRT1 FOXO1 FASN SIRT3 PMC9101148__F2 Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation POMC AgRP PTPN1 STAT3 PMC4353731__F1 Treatment of heterotopic ossification through remote ATP hydrolysis ACVR1 ACVRL1 RUNX2 COL3A1 ID4 BMP2 MSX1 BMP7 SOSTDC1 DLX5 BMP4 CREBBP BMPR2 GREM1 MMP12 GIG8 TIMP1 CXCR4 SMAD1 TGFB1 PMC4065826__F2 MAP kinase signaling in SC plasticity LIF UNK GDNF NRG1 CCL2 JUN PMC6146372__F3 Autophagic control of Toxoplasma gondii ULK1 EGFR TRAF6 CD40 IFNG PMC4858865__F1 Overexpressed metabolic pathways in the infection AIDA ARG1 PMC9069556__F2 Coronavirus Infection and Cholesterol Metabolism CH25H DHCR7 EBP DHCR24 ACE2 TG PMC8305159__F5 Antimelanogenesis Effects of Theasinensin A TYRP1 MC1R PMC11117611__F5 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases LATS1 PTEN MTOR NEDD4 SPRY2 STAT3 PMC11117611__F6 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases IGF1R FBP1 ANXA2 TXNIP PTEN NEDD4 PMC9382309__F4 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression APC RELA DDX5 TCF4 PMC3372922__F2 Action of TIEG in the TGFBeta-Smad signaling pathway SMAD2 SMAD4 PMC11117611__F3 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases IGF1R IGF1 PTEN RDX NEDD4 PMC11117611__F4 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases MYC YY1 NEDD4 PMC9382309__F6 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression DGCR8 DROSHA PMC7952134__F4 Bioinformatic pathway analysis of proteins with altered phosphorylation site occupancy in PPP2R5D E420K-variant cells.A, proteins associated with enriched KEGG pathways identified in F PML VASP CHUK NCBP2 AMOT NCK2 TPR PTEN ARAP1 MTOR LPAR1 MYH1 CDK7 NUP93 WEE1 SI ZEB2 SNX2 CDC2 RNPS1 UVRAG PRKDC JUN SSH1 ROCK2 MPDZ WASF2 APC WIPF1 RRAS SCRIB ABI2 ARHA ASAP2 DHX16 DEPTOR CRK TSC2 EP300 MCM2 CCNB2 RBMX APC2 ATR RBM22 SHC1 MYLK SKP2 PMC7952134__F7 PPP2R5D E420K-variant signaling TSC2 IGF1R IGF1 GSK3B GSK3A RPS6 PPP2R5D PMC7227035__F6 EGFR (a) and NFKB (b) pathway-focused RT-PCR gene expression analysis of representative TNBC PDX RNA samples collected before and after Pan-HER treatment EGF RELB MTOR JUN STAT3 PMC12081406__F1 Biosynthetic pathway of sphingosine 1-phosphate and related molecules DES SPHK1 CERK SPHK2 SMS PMC11211685__F5 Fusarium mycotoxins: The major food contaminants PTEN TNF PMC11211685__F4 Fusarium mycotoxins: The major food contaminants ZEB2 TRO PMC5961061__F1 Structures, enzymes, and reaction mechanisms of lipoic acid metabolism LIPT2 LIAS LIPA SI PMC4816652__F8 Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression MINK1 MAP2 BCR MAPK8 ACVR2A HEL-S-28 MAPKBP1 PRKCH CERK SMAD1 DKFZp781O1323 PMC8884272__F1 Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease TBK1 TRIL IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR4 HTT VTN LBP TAB3 CD36 PMC8356007__F10 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research EGF IL18 CSK PTGS2 EGFR BCL2 MTOR JUN NR1C1 IFNG INSR FASN PMC3575666__F4 VPS4B downregulation increases the expression of mitochondrial fatty acid Beta-oxidation related proteins and down regulates the expression of glycolysis related proteins in SKBR3 cells CS HADHB ENO1 HEL-S-87p IDH3B MDH2 HEL-S-68p HEL-S-162eP FH SUCLA2 ACLY PDHX HEL-S-133P HK2 ACADM HEL-S-281 FASN PMC8356007__F11 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research VHL TFRC GAL HEL-S-87p MTOR HEL-S-133P STAT3 HEL-S-162eP PMC6113216__F7 RGMa regulation of TGFB1/Smad2/3 signaling in astrocytes SMAD2 GFAP SMAD4 RGMA TGFB1 PMC8694403__F3 iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis GPX4 EPO LPCAT3 STEAP3 FACL4 VHL TFRC HEL-S-87p DKFZp686F0183 PRNP TLR4 GC HEL-S-64p CYC1 ADA SLC3A2 CP TF STAT3 PMC9246651__F1 Cellular communication network factor 1 by Ras homolog family member A in bovine steroidogenic luteal cells CYR61 ARHA LATS1 LHCGR LATS2 PMC10040775__F5 Low-protein maternal diet during gestation affects the expression of key pancreatic Beta-cell genes and the methylation status of the regulatory region of the MafA gene in the offspring of Wistar rats EP300 FGF2 INS ATF3 PPARG JUN PMC3708799__F2 PTEN in Beta-Cell Growth TSC2 BAD TSC1 GSK3B MDM2 PTEN MTOR PMC8349889__F7 Gene regulation by EGR1 in ABC DLBCL STAT1 BTK EGR1 BCR NAB2 IRF7 MYC SYK TYK2 JAK1 BRD4 PMC7110906__F1 PI3K/AKT/mTOR signalling pathway BAD ELF3 MDM2 PTEN MTOR DEPTOR PMC8577020__F1 P53 family member p73 in the regulation of cell stress response ATM YAP1 BRCA2 CCNB1 RAD51 GADD45A ATR BAX PMC8326120__F1 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue CGAS QK3 HDAC3 UCP1 TG XBP1 SIRT1 APPL1 PMC9428205__F7 Potential regulatory mechanism of inhibiting autophagy to enhance the cytotoxicity of FIIN-2 on A549 and A549/DDP cells FRS2 MTOR BAX PMC8326120__F2 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue UCP1 GC TG PMC8326120__F3 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue PRDM16 UCP1 TG BMP8B PMC8756491__F1 Biallelic variants in MESD, which encodes a WNT-signaling-related protein, in four new families with recessively inherited osteogenesis imperfecta WNT3 MESD APC SOST WNT1 LRP5 LDLR LRP6 DKK1 PMC8326120__F4 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue TH TSC2 RICTOR TSC1 UCP1 GSK3B PTEN MTOR TG DEPTOR RHEB MLST8 PMC8326120__F5 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue TSC2 TRPV4 PRDM16 TSC1 UCP1 TRPV2 GC TRPV3 TG TRPV1 PMC5241026__F8 RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms ARHA RHPN2 RAB3D SIRT1 PMC8577020__F5 P53 family member p73 in the regulation of cell stress response PSAT1 GLS2 PFKL PHGDH PMC8714953__F1 Porcine Reproductive and Respiratory Syndrome Virus Evades Antiviral Innate Immunity via MicroRNAs Regulation SOCS3 STAT2 IRF7 IRF9 IRAK2 TRAF6 IRAK4 IRF3 IFNAR2 MYD88 TLR3 TLR7 TRAK2 TYK2 MAVS PMC5597737__F1 Activation of NFKB and IL6/STAT3 signalling pathways in NPC cells by multiple EBV-encoded latent gene products CYLD TRAF3 RELB TRAF6 IRF3 IL6 TRAF2 IL6R TLR3 STAT3 PMC5149556__F1 Molecular events that connect inflammation to insulin resistance in obesity TBK1 IL16 TLR4 TRADD TRAF3 IRF3 MYD88 TNF TRAF2 PMC6366304__F2 Common nodes of resistance to targeted therapies within the PI3K pathway BRAF EGFR PIK3CA PTEN INPP4B PIK3R2 PMC6638189__F1 Overview of RNAi pathways in aedine mosquitoes AGO1 AGO2 DROSHA PMC6366304__F3 Targeting the PI3K pathway in cancer with small-molecule inhibitors IRS1 INSR PMC5453110__F1 IL-8/IL-8R axis CXCR1 ATF2 SRC IL8RB SYK PTEN PMC4951400__F4 Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters FGF4 NRG3 BMP3 EPO ADCY1 LRP5 FGF8 NRG1 MTOR DRD2 DRD4 DRD5 CCK WNT3 FGF3 CRH GRB2 SRC GDNF SMO BDNF PMC6906312__F6 Ingenuity Pathway Analysis (IPA) of differential metabolites in POD 7 between GIK and TPN ANGPT4 CP PMC3213398__F7 Working Model for the Late-Acting Function of NFU1 in Mitochondrial Fe-S Protein BiogenesisThe findings of this work suggest a late-acting function of NFU1 in the pathway of Fe-S (red and yellow circles) protein maturation NEU1 ISCU NFU1 ISCA1 PMC6993496__F6 Positional relationships of CDKN3-associated genes in the cell cycle E2F4 SMAD2 SMAD4 DBF4 ORC3 CDK7 ORC2 CDC6 CDK2 MDM2 PCNA SKP2 MYT1 PMC8810313__F1 Viral deubiquitinases and innate antiviral immune response in livestock and poultry TBK1 ISG15 CGAS PLP2 IRF7 TRAF3 TRAF6 IRF3 MAVS PMC6675602__F7 Pterostilbene (PTS) prevented ROS formation and reversed palmitic acid (PA) mediated increase in hepatic glucose production by reducing expression of genes coding for gluconeogenic enzymes and their transcription factors PC NR1C1 PMC6604150__F3 Differentially expressed genes were labeled in the proteoglycans in cancer pathway in the placenta after IVF-ET during the first trimester by KEGG MAFK FRS2 HEL-S-11 TIMP3 EGFR SMO RHO PARL PMC3315368__F4 Gene Array Data from CWR22RV1 xenografts treated with PD325901 for three weeks NF1 EGF MOS NGF EGFR GRB2 RALB BDNF PMC9497767__F4 Epithelial–Mesenchymal Transition by Synergy between Transforming Growth FactorB and Growth Factors in Cancer Progression FGF4 ZEB2 FGF2 CD44 ESRP2 ESRP1 PMC8904967__F2 Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer GPX4 SLC7A11 HEL-S-64p PMC3835685__F1 Human epidermal growth fa ctor receptor 2 (HER2) signal transduction pathways NRG3 EGF BTC NRG2 UNK HBEGF NRG1 PTEN MTOR NRG4 TGFA PMC11542427__F3 Shows that, owing to aging, there is an increased release of proinflammatory adipokines that stimulate the activation of TNF, TGFBR, and insulin receptors ULK1 UCP1 EBP APC KLF5 FOXO1 PMC4657121__F1 Amino acid metabolic pathways targeted in cancer therapy TPH1 BCAT1 SHMT1 GLS2 ASS1 PHGDH ASL PMC6812767__F8 Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions CD14 TLR5 TLR9 TICAM2 TRAF6 MYD88 MAP3K7IP1 TLR10 NR1C1 TLR3 TICAM1 TLR8 TLR7 TLR4 TIRAP PMC6397079__F7 The effect of miR-15a-5p on MK GPVI signaling FYN CRP SYK PLCG2 MYLK PMC8542908__F3 Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis TPM1 EGFR MAPK3 MYC RB1 CCNE1 PMC7646179__F1 FGF/FGFR signaling pathway FRS2 GRB2 APP DOCK1 MTOR CRK CP PMC11275499__F1 Antidepressant potential of ghrelin, which exerts neuroprotective effects by promoting neuronal proliferation and neurotrophic factor production in the brain MTOR BDNF STAT3 PMC5852553__F10 Actin cytoskeleton signaling pathway in Cobb chickens EGF FLNA BAIAP2 APC ARHA ABI2 DOCK1 CRK GNG12 OGA LCK GRB2 LBP HEL114 PXN TRIO PMC4599016__F5 Two separate GA13 Switch Region signaling pathways SRI TPR ARHA PMC4442437__F10 Schematic of proposed mechanism for CpG-induced enhancement of the transepithelial transport of H9N2 WIV in nasal mucosa TLR9 CCL20 CD40 CD80 PMC2912657__F1 NFKB activation pathways ARHA CCL19 REL PMC8593035__F7 Mechanism of NUSAP1 promoting DNA repair process by binding with RAD51 NUSAP1 ATM BRCA2 MDM2 RAD51 PMC11917137__F7 Schematic model for the mechanism and role of HOGA1 in ccRCC CCND1 HOGA1 PMC3670289__F3 Differential STAT3 signaling in the heart GSK3B JAK1 PDPK1 STAT3 PMC8582810__F7 Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer MEI1 DIABLO BAX PMC6456510__F5 Possible regulatory association of miRNA let-7-related gene networks ADRB2 HIF1AN PMC4605443__F2 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective DOK3 GRB2 TEC SYK MYD88 PMC4520659__F4 Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARA expression RARB CRABP2 CRABP1 FABP5 PMC7545926__F8 Schematical representation of the protective mechanism of H2O2 preconditioning for improving the therapeutic potential of BMSCs CXCR4 GSK3B CCND1 MTOR PMC4605443__F1 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective CARD9 GSK3B GRB2 TEC SRC SYK SOS1 PMC5036923__F1 The IMD pathway and its regulation by Die and WntD FZD4 FADD PMC6366304__F1 Common PI3K pathway aberrations found in a variety of solid tumor types PIK3R1 PIK3CA PTEN INPP4B FGFR2 PMC8995746__F1 Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders MAF NLRP3 COX2 KEAP1 TXNIP PMC8323235__F9 ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways EGFR GSK3B IRS1 FOXO1 PMC6001480__F3 Functional networks in mucinous type epithelial ovarian cancer PPL PSMB2 EIF4G1 MED23 KAZN CACYBP ELAVL1 RPAP3 SNW1 NR1A2 PSMB9 PSMB8 PSMB10 PMC9476644__F3 Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism WNT3A APC GSK3B MYC LRP6 BAX PMC5115347__F1 The degranulatory signaling cascade of RBL‐2H3 (adapted from refs LYN SYK LAT PMC7539839__F1 Mitochondrial roles in health and disease MFN1 PINK1 MFN2 FES OPA1 PMC8324678__F3 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD PNPLA3 TM6SF2 ADFP MBOAT7 PMC5294487__F1 Steroid hormone synthesis and endogenous oestrogen metabolism in humans CYP3A4 CYP11A1 CYP1A1 CYP17A1 PMC3350790__F1 Dmrt genes integrate sex-specific, spatial, and temporal cues to induce sexually dimorphic differentiation in restricted groups of cells VAV1 RHO PMC4589549__F4 Canonical Wnt pathway illustrating the roles of PITX2 dependant genes PITX2 APC MYC CD44 CCND1 LRP6 DKK4 NKD1 PMC2633299__F11 UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes COX1 TEP1 PLCB1 PMC3081620__F1 Representative cascade of the TGFB pathway SMAD2 SMAD4 TF PMC5645534__F2 Overall survival mechanism used by the Apicomplexan parasites in different host cells IL10 BAD HGF MMP9 EGFR PTEN MTOR TG SRC BCL2 TRAF2 CP SOCS1 STAT3 BAX PMC2394768__F4 Network diagram comprising genes and functional processes associated with regulated AS events in the CNS GHB2 SYNE1 MYO6 MAPKAPK3 RHO PACSIN2 OPA1 PMC6269430__F5 General mechanism of Wnt induction USP16 PRC1 BMI1 CDKN2A PMC2757291__F6 The SLAM-Associated Protein (SAP)/Fyn/PKCθ Pathway is Required for Thymocyte-mediated CD4 T Cell Development FYN APC TEC PMC8290884__F2 Selective Neuron Vulnerability in Common and Rare Diseases—Mitochondria in the Focus VPS35 PINK1 MFN2 MOS LRRK2 OPTN OPA1 PMC8910853__F3 Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention TGFB1 SIRT1 ALDH2 BAX PMC11765076__F1 Aerobic glycolysis in cancer HEL-S-30 CP HEL-S-162eP PMC8618899__SF1 Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD ASAH2 TSC2 BAD TSC1 GSK3B GSK3A DES SPTLC2 PTEN MTOR SPHK2 SMS PMC3416606__F1 Central carbon metabolism in S HEL-S-26 ACO2 BDH1 ENO1 ENO2 GPD2 tal-1 HEL60 HEL-S-32 MDH2 GPD1 HEL-S-68p PMC11765076__F2 Pentose phosphate pathway and its connections with our metabolic pathways RPIA HEL107 RPE PMC7491459__F3 Schematic diagram sketching three well-characterized pathways (3 vertical lanes) in which TGFB plays a role via signaling and/or transactivation/crosstalk and which may act to promote or prevent hypertension EMILIN1 SMAD2 TGFBRAP1 EGFR HBEGF TGFB1 ADAM17 PMC4130844__F1 Signal transduction and immune response in Helicobacter pylori infected gastric epithelial cells PAK1 TLR4 NOD1 GPT GRB2 SRC IL6 JUN BAX PMC11765076__F4 Serine metabolism pathway PSAT1 SHMT1 DHFR TYMS PSPH HEL-S-51e PHGDH PMC6695959__F1 DNAM-1 signaling pathway leading to natural killer (NK) cell activation FYN VAV1 CD96 TIGIT NECTIN2 PMC11765076__F5 Proline metabolism pathway PRODH PMC11765076__F6 Tricarboxylic acid (TCA) cycle or Krebs cycle SDHC CS DLD IDH3B MDH2 FH ACO2 SUCLG1 OGDH SUCLG2 SDHD SDHA SDHB PMC5398979__F2 Pathway alterations in glioblastoma BRAF PDGFRA CDKN2C DKFZp781B1423 EGFR PTEN RB1 CDKN2A CDK6 NF1 CDKN2B MDM2 CDK4 PMC10344634__F10 Graphical abstract COPS6 HEL-S-87p CDH2 PMC8324678__F1 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD PC ADFP LPA PMC7283464__F2 Enteroviruses regulate apoptosis through the PI3K/AKT pathway BAD MDM2 BAX PMC9107190__F9 Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells PIN1 DAO MMP2 SMAD4 TNF SELE PMC9219453__F5 Relationship between Plasma Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Level and Proteome Profile of Cows HEL-S-62p RBP1 CES2 CFB TFRC ADCYAP1R1 HEL111 CFD RBP5 CFH GNG2 RBP4 RBP2 CFP GNAS TF PMC8037268__F17 Signaling pathways affected by hSDC1 overexpression in DEN-induced hepatocarcinogenesis SDC1 APC EGFR CCND1 HBEGF EIF4E REL DEPTOR AXL INSR PMC7174595__F1 Lysophosphatidic acid (LPA) as a promoter in Alzheimer’s disease (AD) related neurodegeneration CASP3 HEL-S-62p BAD CASP9 ARHA RHO LPA BAX PMC9650365__F1 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease ULK1 ATG12 ATG3 MTOR DKFZp686F0183 BAX PMC7466743__F5 Targeting the CLL/MSC crosstalk using CXCR4/CXCL12 and BCR signaling inhibitors BCR CXCR4 MSC LYN BCL2 SYK CXCL12 PMC3946676__F1 Changing appetites: The adaptive advantages of fuel choice HEL-S-26 ATR PHGDH GLS PMC3946676__F2 Changing appetites: The adaptive advantages of fuel choice SHMT1 MTHFD1 HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC5354934__F3 Anti-tumor activity of metformin: from metabolic and epigenetic perspectives IGF1 MTOR PMC8169546__F1 The Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases KEAP1 EGFR STAT3 PMC6471792__F3 Hypothetical G protein-coupled receptor (GPCR) heterodimeric T1R2/T1R3 taste receptors exist in a multimeric receptor complex with NMBR, IRB, and Neu-1 in naïve IR expressing cells NEU1 EBP MMP9 IRS1 NMBR PMC9392712__F4 Targeting autophagy as a therapeutic strategy against pancreatic cancer ME1 GOT2 GPT2 RPIA CIT RPE HEL-S-32 HK2 MAL GLS PMC7504001__F10 Schematic picture proposing that OXY modulates the IL-1Beta-stimulated inflammatory response IRAK1 TRAF6 IRAK4 PMC3442893__F1 Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment PRODH MTOR ATG14 PIK3R4 PMC9392712__F2 Targeting autophagy as a therapeutic strategy against pancreatic cancer ULK1 ATG16L1 ATG12 ATG3 ATG101 ATG14 DKFZp686F0183 PMC3680918__F6 Schematic diagram of the PIP signaling pathway in ER-negative breast cancer ERBB2 CREB1 ITGB1 PMC8308509__F3 Hypomethylating Chemotherapeutic Agents as Therapy for Myelodysplastic Syndromes and Prevention of Acute Myeloid Leukemia HGF IGF1 UBE2V2 SP1 PRKDC PMC5076460__F6 Global gene profiling of aging lungs in Atp8b1 mutant mice CREBBP ARHH MYL3 ARHA PMC5076460__F4 Global gene profiling of aging lungs in Atp8b1 mutant mice PIK3CD CREBBP F3 RB1 DNAJC3 PMC5076460__F5 Global gene profiling of aging lungs in Atp8b1 mutant mice ATP2B2 ATP2B1 PMC6823401__F10 Figure shows an MPR route that gets activated by the stimulation of progesterone receptor and has a role in cell proliferation by upregulation of PKA/cAMP by the activation of CREB/CREM/ATF-1 EGFR GRB2 SRC EIF4E SP1 RPS6 RHEB STAT3 PMC8657738__F4 Skin Aging, Cellular Senescence and Natural Polyphenols ME1 CS LPA ACLY GLS PMC4826959__F1 Schematic representation of polycomb-repressive complex 2 inhibition mechanisms SET EZH2 ME3 PMC7765584__F4 Gene network interaction of cancer stem cell signaling pathway in (A) LNCaP cells and (B) C4-2B cells with and without enzalutamide treatment MAPK12 MYC FZD4 MAPK11 FZD1 ID3 INHBE PMC5920436__F1 BCR pathway activation BTK BCR LYN SYK MTOR CD79A PMC9557748__F5 Terpenoids and their gene regulatory networks in Opisthopappus taihangensis ‘Taihang Mingzhu’ as detected by transcriptome and metabolome analyses MVD MVK IPP PMC7957739__F1 Dysregulation of signaling pathways by chronic viral hepatitis and epigenetic imprinting impact the secretion of circulating candidate biomarkers to the blood AFP GPC3 EGFR DKK1 MTOR STAT3 PMC6701341__F5 Circadian clock pathway mapped with relative expression levels (T1 vs INA PRL PMC4696776__F2A Insights into acute myeloid leukemia via single cell network profiling PI3 CXCR4 PLCG2 ABCG2 PMC8234087__F2 ChoK-Full of Potential: Choline Kinase in B Cell and T Cell Malignancies TRAF3 MYC FAAH LPCAT1 PEMT TLR4 PC BCR CHKA LACC1 CD40 STM7 PLCD3 PMC6950657__F1 Mechanisms underlying the life-extending and tumor-inhibiting effects of calorie restriction in mammals IGF1R IGF1 NPY MTOR PMC9650365__F2 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease NLRP3 LAMP2 TXNIP MTOR SIRT1 GSDMD SIRT3 PMC8190181__F1 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer EREG SMAD2 CD44 SMAD4 TCF12 LPA FAP IL33 SRC SKI IGF2R SOCS1 STAT3 PMC5899973__F3 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis TNF MME PMC5899973__F4 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis FOS MYC SRC IL1B IFNG PMC3653888__F3 Yin Yang 1 and Adipogenic Gene Network Expression in Longissimus Muscle of Beef Cattle in Response to Nutritional Management RXRB KAT2B NR1i1 YY1 ENG PPARG STAT5B IGFBP5 IFNG GTF2B PMC3252343__F4 Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner STAT1 ISG15 OAS1 IFI27 EIF1AD MX1 IFIT1 USP18 PMC3653888__F4 Summary of YY1 gene network expression in steers comparing early weaning (EWS) against normal weaning without creep feeding (NWN) at 240 days on treatment.Notes: Cellular locations depicted are from the Ingenuity Pathway Analysis® knowledge base RXRB KAT2B NR1i1 YY1 PPARG STAT5B IGFBP5 POLI PMC11601888__F4 Function analysis of the high-confidence functional lncRNAs SOX2 SET NODAL SMAD2 FGF2 SMAD4 WAS RAN BMP4 PMC9069003__F3 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 MAF NLRP3 KEAP1 ACE2 IL1B PMC9069003__F4 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 NLRP3 KEAP1 HIF1A ACE2 IL1B PMC7450930__F7 Distribution of the target proteins of Xiaochaihu decoction on the predicted pathways (The red nodes are potential target proteins of Xiaochaihu decoction, while the orange nodes are relevant targets in the pathway) MMP2 GSK3B UNK CCL2 INSR STAT3 PMC8835790__F1 Epigenetics in the Diagnosis and Therapy of Malignant Melanoma HEL-S-61p HEL-S-182mP MTR SMOX SRM MTRR UHRF1 AMD1 ARG1 HEL-S-20 SMS PMC9213320__F1 Scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis CASP3 RIPK1 TRADD CYLD SHARPIN RIPK3 TRAF2 FADD MLKL TAB3 PMC5397865__F8 Salt suppresses IFNG inducible chemokines through the IFNGamma-JAK1-STAT1 signaling pathway in proximal tubular cells STAT1 CXCR3 CXCL1 CXCL10 CXCL9 IFNGR2 JAK1 IFNGR1 IFNG PMC11753526__F6 Type I interferons attach to their receptors, causing tyrosine kinase 2 to phosphorylate tyrosine and activate STAT1 and STAT2 STAT2 IRF3 TYK2 PMC12241195__F5 Tackling Wnt signaling by the Wnt inhibitor SM04690 APC GSK3B ARHA PRG4 SIRT1 FOXO1 DYRK1A CLK2 PMC4511561__F5 Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome E2F4 SMAD2 SMAD4 DBF4 ORC3 CDK7 CDK6 ORC2 SMC3 CDK2 ORC1L CDK4 MYT1 PMC8238877__F1 SARS-CoV-2 signals through TLR2 to activate proinflammatory cytokine expression CXCL10 MYD88 TNF PMC7539765__F5 Probable interactions among TRIP13 and other molecules within clear cell Renal Cell Carcinoma MTOR TRIP13 HES1 PMC8586510__F2 Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh KIT WNT3 WNT4 PITX2 FGF8 SHH WNT10B WNT7B PMC11753526__F2 Comprehensive examination of the Toll-like receptor 9 (TLR9)-mediated signaling pathway IRAK1 CCL20 TRAF6 IRAK4 IL6 CCL2 MYD88 TNF TIRAP TAB3 PMC6351931__F10 Schematic diagram of the signaling pathway relevant to HKMT-induced pleural fibrosis in pleural mesothelial cells (PMCs) TLR4 NOX4 PMC8534156__F3 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers CSK GRB2 SRC PMC8534156__F5 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers SRC CRAT CBL PMC4367644__F1 IGF-1R Signaling Pathway BAD IGF1R IGF1 PTEN MTOR PMC4494900__F3 Emerging role of CaMKII in cancer TIAM1 CDK4 PMC6833135__F3 Gene expression levels of central carbon metabolic pathways TH HEL-S-49 HEL-S-26 PGM2 ACO2 ENO2 ADH5 CIT HEL60 HEL-S-4 MDH2 MAL PMC4541321__F2 Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case PRODH CSA2 PMC2448841__F5 Proposed model of arrest of maturation/activation of DCs via ILT4 receptor and HLA-G ligand HLA-G TLR4 CSK TRAF6 MYD88 STAT3 PMC8672651__F1 Complement as driver of and therapeutic target in COVID-19 CD46 MASP1 FH RELA MASP2 C1S ACE2 PMC8570289__F1 Key Activating and Inhibitory Ligands Involved in the Mobilization of Natural Killer Cells for Cancer Immunotherapies HLA-E VAV1 CD48 TIGIT MTOR HLA-B HLA-C HLA-A FYN LCK ZAP70 GRB2 SYK PMC11854242__F5 YAP-mediated gene expression in liver fibrosis ROCK2 ANKRD1 SRC ARHA LATS1 LPA COL1A1 LATS2 PMC11854242__F6 Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy COL3A1 ACTA2 SMAD2 SMAD4 PMC11854242__F4 Rho/ROCK/MRTF/SRF transcription pathway and its upstream regulation by the actin cytoskeleton in liver fibrosis ROCK2 ROCK1 SRC ARHA LPA COL1A1 PMC9037381__F2 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells SNAI1 PMC5625807__F2 Genes identified from the enrichment analysis were significantly associated with OSA comorbidities LEP EDNRA LIPC HTR3D LEPR ADRB2 HTR2A PMC8102094__F3 Positive and Negative Regulation of Ferroptosis and Its Role in Maintaining Metabolic and Redox Homeostasis ATM SLC7A11 GLS2 PMC2661962__F1 Where Do MAIT Cells Fit in the Family of Unconventional T Cells? CD27 CD1D ZBTB16 MR1 PMC6003288__F2 Luteolin inhibition of receptor-mediated tumor progression.Notes: Involvement of luteolin (green) in modifying processes necessary for metastasis FOXO3A GSK3B PTEN MTOR PMC6003288__F3 Luteolin-mediated extrinsic and intrinsic apoptosis in breast cancer.Notes: Illustration abridging the involvement of luteolin (green) in purposed apoptotic pathways FADD BAX PMC9037381__F3 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells NLRP3 HMGB1 ADAM8 IL1A CD46 MMP9 NLRX1 NLRP10 PMC8203678__F5 Genome-wide portrait of pervasive drug contaminants ARG2 ARG1 CPA2 CPA1 PMC7841880__F1 Canonical PTEN pathway depicting PI3K/AKT/mTOR and MAPK/ERK signaling RICTOR PI3 EIF2A PTEN MTOR PMC7333890__F2 Stress responses to aneuploidy and radiation ATM ATR PMC3359076__F5 Regulation of thrombin-induced RelA/p65 nuclear translocation by the Rho-actin pathway RELA ARHA CSA2 PMC4077945__F1 Lipid metabolites as metabolic messengers in inter-organ communication ELOVL6 NR1C1 PMC4979518__F6A mTORC2 controls cancer cell survival by modulating gluconeogenesis CHUK PCK1 AKT1S1 MTOR MAPK1 PCK2 PGAM1 SGK1 PGAM2 ALDOB ENO3 FBP2 FBP1 ENO1 HEL-S-87p RHEB RXRA HEL-S-162eP HEL-S-68p TSC2 RICTOR PRMT1 TSC1 CDK2 ENO2 STAT3 FABP1 PMC3134408__F1 Proposed molecular pathways in arterial, venous and lymphatic specification in a developing embryo FOXC1 HEY2 SOX18 PROX1 FOXC2 SOX7 EPHB4 NRP2 PMC11053014__F1 Model of Hippo sinaling pathway in mammalian cells and the activity of Hippo sinaling pathway controls the dynamic localization of YAP/TAZ between nucleus and cytoplasm NF2 LATS1 LATS2 PMC11053014__F2 Molecular mechanism by which mechanical cues regulate YAP/TAZ NF2 ARHA LATS1 LATS2 PMC6352980__F2 Paths to stemness: building the ultimate antitumour T cell TCF3 DUSP9 SMAD2 LIF APC GSK3B LRP5 SMAD4 LRP6 IL24 LATS1 MTOR ID1 LATS2 ID3 BMP4 TSC2 KLF4 KLF2 SMAD1 STAT3 PMC6988818__F2 The Renin-Angiotensin System and Vitamin D in Keloid Disorder—A Review NR1i1 SELL PMC4580089__F1 Intracellular trypanosomatid parasites evade the protective role of IFNG signaling by targeting essential components of the JAK-STAT pathway STAT1 IRF-1 IFNG PMC5362524__F8 Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NFKB in vitro EGF EGFR BAX PMC8324391__F1 Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy TFEB KEAP1 ULK2 ATG14 SIRT1 FOXO1 PMC4951124__F6 CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling CXCR4 EGFR SMAD4 SRC CXCL12 PMC8396202__F2 Cell-Free DNA in Rheumatoid Arthritis TBK1 CGAS IL18 TLR9 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 AIM2 PMC2723817__F1 Targeting lung inflammation: novel therapies for the treatment of COPD CXCL1 CCR2 IL8RB HDAC2 CCL2 SLPI PMC11913674__F1 mRNA vaccines immunogenicity RNASEL TBK1 TLR8 TLR7 BCR IRF7 APC RIGI IRF3 MYD88 TLR3 MAVS PMC5671742__F2 Anticancer drugs that induce oxidative stress on endothelial cells ERBB4 ERBB2 NRG1 PMC8190181__F2 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer NODAL SMAD2 MMP9 SMAD6 SMAD4 RHO DNMT3B SMAD9 MMP2 FOXA1 CXCR4 FAP GREM2 CXCL12 SMAD1 DKFZp781O1323 STAT3 PMC8190181__F3 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer SPARC HGF NODAL CXCL5 BMP2 SMAD2 IGF2 EGFR CD44 PTEN MTOR VCAM1 CXCR4 CXCL12 PMC8190181__F4 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer VCAM1 TWIST1 ATF2 POSTN CXCR4 EGFR GFER CDH2 FASN PMC5723914__F1 FGFR signaling pathway FRS2 GRB2 PMC12026832__F3 Signaling pathways in cardiac fibroblast TBX20 ACTA2 APC TEAD4 LATS1 CDC2 MTOR LATS2 TCF21 PCNA SOX9 PMC8221395__F4 Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment MAF PIR FTL PMC4983539__F1 Innate Immune Evasion Strategies of DNA and RNA viruses TBK1 IRF7 TRAF3 IRF3 TRIM25 MAVS PMC4986693__F6 Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2 and P-ERK EGR1 CCND1 CCKBR PMC4261029__F1 Schematic illustration of the mTOR signaling pathway, including major upstream regulators and downstream substrates for both the mTORC2 and mTORC1 kinase complexes TSC2 RICTOR TSC1 TBC1D7 PTEN MTOR IRS1 RHEB MLST8 PMC11618000__F8 MST2-mediated Hippo signaling pathway involved in T TEAD3 TEAD4 LATS1 TEAD2 PMC8605871__F7 Whole Exome Sequencing Study in a Family with Type 2 Diabetes Mellitus TSC2 ULK1 IGF1 F2 INS MTOR RHEB CFTR INSR CD36 PMC5957449__F3 Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage AHR MAFF GSTM5 NFE2L2 GSTM4 ABCC1 GSTM1 GSTM3 POR CYP1A2 PMC4459531__F1 Serrated Pathway to Colorectal Cancer BRAF APC CDKN2A PMC3206070__F2 Temporal Order of Genetic and Pathway Alterations in Tumorigenesis EPHA3 EGFR APC TGFBR2 SMAD4 PXDN TCF7L2 PTEN RB1 CDKN2A HEL-S-26 EVC2 PIK3CA PMC6590809__F1 Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC4115279__F1 Death-Defining Immune Responses After Apoptosis APAF1 CAD FADD BAX PMC2690992__F2 Signaling control of mesenchymal and amoeboid cell phenotypes NEDD9 DOCK3 RHO RAC1 ARHGAP22 PMC4013251__F1 Canonical microRNA (miRNA) biogenesis pathway: miRNAs are initially transcribed as long, variable-length hairpin RNA substrates called primary miRNAs (pri-miRNAs) directly off the DNA template in the nucleus by RNA polymerase II (A) AGO2 DGCR8 DROSHA PMC7982415__F4 NLR-mediated signaling pathway in mammals NLRP3 IL18 NOD1 MAP3K7IP1 AIM2 CASP5 IFI16 GSDMD CASP4 PMC4781997__F3 Apoptosis through death receptors: a signaling pathway in TLE(HS) NFKBIA TNFRSF6B RELA TNFRSF1A RB1 TNFRSF10A CASP8 PMC7982415__F2 TLR-mediated signaling pathway IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 CASP3 NLRP3 TLR7 TLR4 FADD MLKL TAB3 PMC7499322__F2 Promotional roles of MSC-derived exosomes in tumors MSC FGF19 PMC7499322__F3 Inhibitory roles of MSC-derived exosomes in tumors PLK1 MSC PMC4892133__F1 Rapid degradation of HIF-1A by the ubiquitin-proteasome pathway, during normoxia CXCL1 EPO PMC4189449__F1 Pathway where human papillomavirus (HPV)16 E5, E6 and E7 oncoproteins regulate cyclooxygenase-2 (COX-2) expression associated with the cervical carcinogenesis HDAC3 EGFR JUN PMC3678733__F3 Visualization of curated components of pathways and inferred interacting proteins and small molecules CDK3 STK24 LATS2 PMC3678733__F1 Human Hippo signaling pathway HEL2 AMOT HEL-S-1 DVL2 PMC7143141__F1 Long-term recreational football training in successful aging TSC2 NAMPT ATG12 MTOR TFAM PMC8226666__F2 Hippo Pathway: A Master Regulatory Network Important in Cancer MTOR JCAD PMC11641450__F2 Modulation of WNT/Beta-catenin signaling pathway by natural compounds in cancers APC GSK3B LRP5 LRP6 DKK1 BCL9 PMC4741750__F3 Down-regulation of IKKB expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma PIK3CD TLR5 MAPK9 MAP2K4 CXCL10 MAPK14 TRAF3 MAP3K7 TRAF6 IRAK4 CXCL2 CCL4 MYD88 MAP3K7IP1 NFKBIA TLR7 NFKB1 PIK3CA CD40 CD80 PMC8226666__F1 Hippo Pathway: A Master Regulatory Network Important in Cancer SRC RHO PMC8533696__F3 Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives NUMB DLL4 BCL2 MCL1 STAT3 HES1 PMC6046102__F1 TNBC: The current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics NF1 PI3 DUSP4 ATM BRCA2 EGFR PTEN CDC25B INPP4B MTOR ATR BRCA1 PMC10540835__F1 Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe? TH NLRP3 IL1B PMC4661875__F2 Intrinsic and extrinsic apoptotic pathways: The intrinsic, or mitochondrial, pathway is initiated from within the cell in response to DNA damage, loss of cell-survival factors and severe cell stress TRADD DIABLO FADD PMC2887084__F1 New Strategies in Head and Neck Cancer: epidermal growth factor receptor inhibition in head and neck cancer EGF GRB2 CCND1 SRC HBEGF PTEN HRAS MTOR TGFA PMC3837032__F7 Impaired Nrf2 activation and antioxidant gene expression in fetal endothelial cells in GDM MAF KEAP1 GSK3B PMC3203325__F2 XPC: Implications in cancer and oxidative DNA damage POLE POLK XPC ERCC1 DDB2 PCNA PMC3552145__F10 PGN-induced miR-132 and miR-212 in TLR signaling CD14 TLR5 TLR4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR1 PMC4896389__F4 Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence PIGF CXCL16 HGF ASB1 CXCL10 CXCR4 TGFBR1 VEGFA CXCL9 CD80 CXCL12 CXCL11 PMC3121188__F7 ERK-dependent signalling during conditioning and extinction of fear JDP2 FAP JUND PMC4351152__F1 MTOR pathway is regulated by numerous upstream pathways, typically in response to growth factors (anabolic) or energy/nutrient deficiency (cell static or catabolic) RICTOR PTEN MTOR RHEB PMC7003380__F1 Biology of ICOS in the tumour microenvironment TH APC CTLA4 ICOS FOXP3 PMC7003380__F2 Targeting regulatory and/or effector T cells with ICOS agonistic or antagonistic antibodies APC CD80 ICOS PMC2430694__F2 Inflammatory Pain: The Cellular Basis of Heat Hyperalgesia IGF1 NGF TRPV1 PMC4251421__F2 Simplified diagram of the mammalian target of rapamycin (mTOR) signaling pathway and its relationship with autophagy and apoptosis TSC2 TSC1 RHO RHEB PMC5727303__F2 Inhibitors of Wnt signalling APC LRP5 LRP6 TNKS BCL9 PMC8134874__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells TAOK3 LATS1 RHO LATS2 TAOK1 TAOK2 PMC6149873__F1 Inverse relationship between canonical and non-canonical Hedgehog signaling in colon cancer stem cell (CSC) differentiation PTCH1 SMO PMC10706788__F13 Pathway of glutathione metabolism by EHP in the late stages of infection LAP3 PMC10706788__F10 Pathway of purine metabolism by EHP in the early stages of infection HAMP APP OTP ADM PMC10706788__F11 Pathway of glutathione metabolism by EHP in the early stages of infection LAP3 PMC6776186__F6 Graphical abstract of the model of the activation of IL2RG/JAK/STAT following the overexpression of the ITK-SYK fusion gene ITK IL2RG SYK PMC8134874__F3 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells PLCG1 PLD2 ARHA LATS1 ARHGAP29 LATS2 PMC8155538__F2 Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis GPR161 GLI3 SHH AQP2 SMO NEK8 CFTR PMC5712254__F1 Metabolic Advantages and Vulnerabilities in Brain Metastases RPIA PFKP HK2 GLS PMC6764236__F2 Regulation of neutrophil metabolism MTOR HEL-S-5 PMC6540463__F3 PI3K-AKT signaling pathway which was achieved by DAVID pathway analysis TSC2 BAD BCR MDM2 PTEN RAC1 MTOR RBL2 CD19 HEL-S-69p PMC6540463__F4 Hippo signaling pathway which was achieved by DAVID pathway analysis AFP PATJ GIG8 AMOT AREG APC MYC PALS1 PMC8924093__F3 Anti-HER2 therapy in metastatic breast cancer: many choices and future directions IGF1 EGFR CCND1 CDK4 PTEN MTOR CDK6 PMC6011341__F3 The Base Excision Repair Pathway FEN1 POLE LIG1 PCNA PMC4012266__F2 The autophagy process and signaling pathway ATG12 ATG3 ATG10 MTOR DKFZp686F0183 PMC3432194__F2 Epistasis network for WTCCC GWAS of bipolar disorder SORCS2 DKFZp313C1916 SLC24A2 WDR27 SLC24A1 TDG CMPK2 POPDC1 GNA14 OGFRL1 TMEM200A DPP6 CSMD3 PLLP SUDS3 STAB2 DCDC1 SNX16 ARPP-21 SELL IPMK GPR37 ELMO1 ST6GAL2 BHLHB2 SLC10A2 FBXW11 ZIC1 PLAA SPTLC3 NAPG POTEA CTNNA2 WWOX ADD1 RREB1 RIOK2 IFT140 RNASE1 KMO CAV3 MRPS23 PSME4 CELF2 CEP290 ARL15 SLC24A3 RBM19 WDFY4 HRH2 NEIL3 RIOK3 SOSTDC1 EDIL3 GRIK2 FAT3 HEL-S-18 LMO4 FHL2 SYDE2 NGRN LIPN ARAP2 TMTC2 PMC7875896__F8 Protective mechanism of levo‐tetrahydropalmatine against liver fibrosis TIMP1 MMP2 SMAD2 PMC6588884__F2 MET protein structure (a) and HGF/MET signaling pathway (b) HGF GRB2 PMC8209516__F3 Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells SOX2 NOTCH1 PMC9526459__F2 Revisiting potential value of antitumor drugs in the treatment of COVID-19 TLR8 BTK TLR7 TLR3 PMC9496095__F2 Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis KLHL3 WNK1 WNK4 PMC8745273__F6 Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators PLCB4 PRKCH FBXW11 PCDH19 PMC4252624__F5 Glutathione peroxidase activity pathway which was significantly altered in the liver of female LMB, obtained from GSEA, featuring GO terms GPX4 LOC51064 GPX1 ALOX5 MGST3 IL6 HEL-S-128m TXN GPX7 GSTT1 CASP3 GPX3 GPX2 BAX PMC8662121__F1 Type I interferon in the treatment of COVID‐19 TBK1 TLR8 TLR7 TLR4 IRF7 IRF3 MYD88 ACE2 TLR3 MAVS PMC4252624__F6 Classical Complement Pathway affected in the ovary of female LMB (by gene set enrichment analysis (GSEA)) HEL-S-62p C8A C9 C4B_2 C7 C6 C1S PMC8662121__F2 Type I interferon in the treatment of COVID‐19 STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC7261019__F1 Rerouting of glucose utilization in RA and SLE T cells PDP2 PMC7814730__F4 DILI-related processes inferred from predicted targets and pathway annotations CSNK2A2 PTGES AKR1B1 ESRRA HEL-S-104 AKR1C2 CYP1A2 NQO2 CCNB3 CYP2C9 NR1B3 PLA2G1B CCNB2 DYRK2 PRKAB1 RPS6KA6 PMC6156325__F4 BH4 modulates the nitrosation of key proteins in the Ubiquitin-Proteasome system PSMD6 PSMD2 PSMD11 PMC5524794__F1 Protoporphyrin IX biosynthetic pathway in the shell gland of brown egg laying hens ABCB6 FECH UROD SLC25A38 UROS CPOX ABCG2 PMC2692422__F7 IL-1Beta-induced upregulation of RGS4 expression in colonic SMCs via canonical IKK2/IKBA/NFKB signaling is differentially modulated by the MAPK and PI3K/Akt/GSK3B pathways RGS4 GSK3B IL1B PMC5901847__F1 Diagram of signal pathways and molecules participating in the preservation of the pluripotency state and reprogramming EGF BAD SOX2 SET SAG SUFU APC LIF GRB2 CASP9 SMO PMC3446495__F1 Impaired immune system in patients with systemic lupus erythematosus (SLE) IL10 UBE2L3 IRF7 IRF8 APC TNLG2B HLA-DRB1 BLK PTPN22 ITGAM PDC RASGRP3 STAT4 LYN TNFAIP3 IFIH1 NCF2 PMC7230071__F1 Key regulators of ferroptosis GPX4 LPCAT3 FACL4 KEAP1 SLC7A11 PGP MDM2 SLC3A2 BAP1 PMC9573482__F7 Quercetin and Resveratrol Differentially Decrease Expression of the High-Affinity IgE Receptor (FcERI) by Human and Mouse Mast Cells EIF2A LYN GRB2 SYK LAT PMC4015830__F2 Intersection of BC modules 143, 79 and 82 CCNA2 EEA1 ERBB3 UBTF KRT27 ERBB4 CDKN1A INSRR IL20RA CDK3 CBLC RBL2 IL2RB SKP2 PMC7140647__F5 Different potential contributing players and their pathways activated in proposed antibody-dependent NK cell-mediated cytotoxicity in the thyroid gland of AITD patients PAK1 MICB MICA TPO SYK HLA-C PMC5657500__F1 Death receptor signaling in the heart: cell survival, apoptosis, and necroptosis CASP3 TRADD CASP9 TRAF2 FADD MLKL BAX PMC8998918__F4 Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer BAD PLAT ERG PTEN TF PMC6707065__F1 Normal Adrenal Steroidogenesis Pathway HSD11B2 CYP11A1 HSD3B2 CYP17A1 CYP21A2 STAR CYP11B2 PMC5878942__F3 Physiology and role of irisin in glucose homeostasis COX2 PCK1 PRMT3 FOXO1 PMC4467417__F5 Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/Beta-catenin pathway WNT3A DVL2 ITCH PMC5878942__F2 Physiology and role of irisin in glucose homeostasis PCK1 TFAM NR1C1 PYGM HK2 PMC2474812__F1 Classical and back-door pathways of androgen biosynthesis STS CYP11A1 AKR1C1 CYP7B1 HSD17B2 UGT2B17 HSD17B3 AKR1C2 CYP17A1 UGT2B15 PMC3923149__F2 Co-regulation of hepatic wound healing and regenerative responses via TWEAK- and LTBeta-mediated cellular cross-talk LTB CCL2 LTBR PMC8301972__F2 Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition SNAI1 EPCAM TWIST1 SNAI2 PMC6800286__F7 The pathway leading to IL-1B release from NK92 and its inhibition by DMF or MMF DNMT3B IL1B GSDMD PMC2615236__F1 Regulation of IGF-I Function by Proinflammatory Cytokines: At the Interface of Immunology and Endocrinology TSC2 PI3 BAD IGF1R GRB2 EIF4E MTOR AKT3 PMC6915875__F6 The mechanism of AML cell-secreted exosomal miR-4532 in hematopoiesis of HSCs LDOC1 DKK1 STAT3 PMC5803787__F7 Model for the fate decision of XY PGCs regulated by stage-specific FGF9 levels NANOS2 STRA8 FGF9 PMC5413166__F5 An example of innate immune response induced by E2 in ML-1 cells CXCL16 PSG1 MAFF SACS CYC1 SALL2 PORCN SCARB2 PMC4383884__F5 Cisplatin response pathway SLC47A1 SLC22A4 SLC22A2 PMC5250589__F1 Impact of ELS on the normal development of tissues and organs NGF GC CRP BDNF PMC6262822__F1 Parts of the signaling pathways of the five mutated proteins in the 5 syndromes of this review CASR TSHR FSHR PMC3197531__F12 Beta-Adrenergic Receptor-PI3K Signaling Crosstalk in Mouse Heart: Elucidation of Immediate Downstream Signaling Cascades GSK3B GSK3A MTOR PMC3641604__F9 The innate immune antiviral response triggered by IFNB and TNFA in AECs TBK1 TRAF3 DUOX2 TRAF6 RIGI IRF3 MAVS DUOXA2 IFIT1 PMC4940190__F1 Adipose tissue dysfunction and its effects on tumor metabolism MTOR XBP1 HEL-S-133P HK2 HEL-S-162eP PMC3732559__F5 HMGB1 in Cancer: Good, Bad, or Both? HEL-S-102 HMGB1 ULK1 PMC12167820__F2 Transcriptome analysis of S CS FH DAP PCCB HEL-S-162eP PMC2984446__F10 PI 3 Kinase Related Kinases-Independent Proteolysis of BRCA1 Regulates Rad51 Recruitment during Genotoxic Stress in Human Cells BARD1 RAD51 BRCA1 PMC4673337__F1 Innate receptor signaling and stefin B influence NFKB activation and caspase-11 expression in macrophages NLRP3 CD14 IL18 TLR4 LBP MYD88 TIRAP PMC6116003__F2 Pathway for Type I tumor formation BRAF ERBB2 PTEN ARID1A PMC2843693__F2 Molecular Origins of Cancer BRAF APC EGFR TGFBR2 SMAD4 PIK3CA PTEN BAX PMC4850162__F2 Riboclustering-mediated signaling pathways that regulate innate inflammatory modulators, including cytokines/chemokines TLR5 TLR4 HEL-S-76p TLR3 PMC6116003__F6 Wnt Signaling Cascade APC LRP5 LRP6 PMC2811231__F7 Gene program of neutrophil recruitment and tissue injury based on gene expression and in vitro data PTGIR PLAUR TNFAIP6 IRAK1 FPR1 PTGS2 CD44 PTGES ALOX5 IL1R1 PTGER3 MYD88 LTB4R FUT7 CSF2 FCAR B4GALT1 IL1B PMC3819010__F2 EBPR metabolic map inferred from the Accumulibacter clade IIA genome, adapted from ) PDC MMD ATR ADK PMC4472235__F2 Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease TSC2 TSC1 PC ELF3 RHO EIF4E RPS6 HIF1A MTOR EIF4B RHEB INSR PMC5136518__F1 Alterations in DLPFC layer 3 pyramidal cells in schizophrenia LIMK2 PAK1 LIMK1 HEL-S-47e CDC42 PMC6078908__F6 Conceptual Circuit Model for How External Warming Induces and Links Sleep and Body CoolingSkin warming activates a pathway that runs through the spinal cord and is relayed by glutamatergic neurons in the lateral parabrachial nucleus [, , ] MPO LPO PMC3624298__F1 Downregulation of human NK cell-mediated cytotoxicity pathway genes in response to Gal-9 HLA-E ULBP2 MICB ICAM2 KIR3DL1 CD48 KIR3DL2 ULBP1 MICA ULBP3 HLA-B PMC6822471__F4 Docosahexaenoic acid (DHA) signaling pathway detected by GSEA PIK3C2B BAD BIK GSK3A BCL2 BCL2L1 CYCS BAX PMC4393792__F2 T Cell Metabolic Fitness in Anti-Tumor Immunity AHR MCL1 HIF1A SIRT1 IFNG BAX PMC7311998__F5 Molecular mechanisms of ID1-mediated BMP signaling pathway to control GLP-1 secretion in GLUTag cells BMPR2 ID1 SMAD1 DKFZp781O1323 BMP4 SMAD9 PMC5134126__F1 Osteoclasts arise from hematopoietic monocyte/macrophage precursors upon interaction of RANKL with its receptor RANK NFATC1 FOS SMAD2 SMAD4 TRAF6 PMC4177360__F5 TLR signaling and CXCR4/7 in human liver MDB formation TLR4 CXCR4 MYD88 TLR3 PMC8909056__F1 Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity TH FOXO3A DOHH PMC7531038__F6 Possible intracellular signaling pathways activated in chondrocytes upon treatment with pararama hair extract HEL-S-62p MAP2K4 SMAD2 VEGFA CD44 SMAD4 IL6 CCL2 MAP3K7IP1 CXCL16 NFKBIA TLR4 SP1 TGFBI PMC7230488__F2 MAPK signaling pathway with nodes color-coded based on the z-value obtained from the meta-analysis of the GSE53987, GSE12649 and GSE21138 datasets CHUK BRAF TRADD MAP2K4 FLNA ATF2 TGFBR1 MYC TRAF6 MAP2K3 MAP2K6 NF1 TNFSF6 HEL-S-11 ATF4 ECSIT RAPGEF2 ARAF CD14 CACNG3 FOS TAOK3 MAP2K2 TNF MAP3K7IP1 CRK NFATC3 NLK HEL-S-102 PAK1 DUSP10 MAP2K1 MAX NFKB1 RASGRF1 GRB2 MAP3K14 JUND RAF1 SOS1 CSF1 TRAF2 MEF2C DUSP3 TGFB1 AKT3 PMC5520917__F8 OA-induced growth inhibition of colon cancer via reprogramming fatty acid metabolism under hypoxia APC HIF1A FASN PMC2634968__F6 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling IRAK1 TIFA AJUBA PMC3724356__F2 Molecular events in cholangiocarcinogenesis EGF ERBB2 EGFR MDM2 BCL2 PMC2634968__F7 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling TLR8 TLR5 TLR7 TLR4 TLR9 IRAK1 TIFA TRAF6 MYD88 TLR1 TLR10 PMC8504951__F7 Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway FGFR1 FGF2 VEGFA SRC STAT3 PMC8062762__F4 Summary diagram showing potential points in endometrial cell signaling pathways which may be influenced by BVDV infection RSAD2 IRF7 TRAF3 TRAF6 IRF3 IFNAR2 IFNAR1 TLR3 IFNG STAT1 TLR8 TLR7 TRIM56 TYK2 IFIH1 PMC3042723__F2 Signaling pathways regulating dendritic spine actin remodeling with the induction of LTP by theta burst stimulation (TBS).Schematic of signaling pathways linking three classes of synaptic to regulation of the actin cytoskeleton SRC ARHA CDC42 PMC3672788__F6 Summary for the effect of calcineurin inhibitor, tacrolimus, on the regulation of RANKL expression through IL-6/sIL-6R/JAK2/STAT3/SOCS3 pathway SOCS3 STAT3 PMC7976506__F5 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease FPR2 CIT PMC3734934__F6 Disruption of mindin exacerbates cardiac hypertrophy and fibrosis SMAD2 SMAD4 PMC6627624__F5 Scheme to summarize the current understanding of triterpenoid biosynthesis in metazoans MVK IDI1 PMC3263561__F2 Interaction between glia and neurons may lead to neuron damage and death CD14 TLR4 LBP PMC6627624__F7 Scheme of the post squalene pathway for cholesterol biosynthesis BOC SI SMO PMC6635068__F1 Rb pathway loss and assays for their detection CCND1 CDK4 RB1 CDKN2A TF CDK6 PMC2634968__F2 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling IRF7 IRF3 PMC9295467__F2 Generation of Leydig-like cells: approaches, characterization, and challenges SCARB1 CYP11A1 LHCGR HSD17B3 CYP17A1 STAR PMC8868544__F1 AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis AHR KEAP1 PAH PMC3788325__F2 Signaling pathways in RILF FOXM1 GSK3B ARHA PMC2634968__F5 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling VAV1 RAC1 TLR3 PMC6446225__F1 Proposed overview of the vascular immunopathology of sickle cell disease (SCD) ANXA1 TLR4 TFPI FPR1 FPR2 CD36 PMC7678118__F5 PDGFRA/EGFR signaling activation and effects on RAS/MAPK pathway EGF GRB2 SRC SOS1 TGFA PMC11213636__F7 Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGFB/Smad Signaling Pathway SMAD2 SMAD4 PMC7772566__F6 Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening HDAC3 IDI1 AASS NMNAT3 HEL-S-104 RPS29 UQCRFS1 ACSL5 PNMT SCD FDPS ARG2 CYP4A22 BST1 UQCR10 PSME4 MRPL12 SP1 HSD17B11 PSMB9 COX7C OAZ3 RDH11 PPP2R3C SQLE NAMPT VNN2 SOX2 RPL38 MVK HMGCS1 ACAT2 PSMD3 EP300 MVD DHCR7 PSAT1 NDUFA10 ACLY CIDEA PPARG ACOX3 MSMO1 PMC10565042__F1 Diverse types and molecular mechanisms of the Wnt signaling pathway ROCK2 DAAM1 APC ARHA RYK RAC1 CDC42 PMC5538118__F2 Molecular map of pathways that lead ROS to cause OPC dysfunctioning in SZ TSC2 TSC1 FYN PDGFRA PDGFA MTOR NR1C1 RHEB PMC10565042__F2 Involvement of ncRNAs in modulating the Wnt signaling pathway in prostate cancer APC RYK PMC10502727__F1 Basic research on chordoma EGFR MTOR PMC9126727__F4 Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking PTGS2 COL1A1 PMC10565042__F3 Wnt signaling pathway-related ncRNAs in the regulation of invasion and migration in prostate cancer TLE3 NDRG2 HMGB3 APC CD44 TCF7L2 RAC1 FZD5 NKD1 FZD2 SOX30 SFRP1 TUG1 EZH2 DIXDC1 PMC10565042__F4 Wnt signaling pathway-related ncRNAs in the regulation of EMT, apoptosis, stemness, and CRPC formation in prostate cancer LEF1 RAB11A APC FZD2 CD44 SFRP1 PMC7789127__F1 Dual-specificity tyrosine-regulated kinase 1B expression and activity RLF RHO MTOR DYRK1B PMC7655968__F2 Simplified representation of the structured reaction pathway of glycolysis (Maria, ), and of the TRP synthesis (in the yellow area) (Maria et al., ) in E PTS CIT MAL PMC4428446__F2 Scheme of the signal transduction pathways that control C CST5 CDC42 PMC9274486__F8 miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer EGFR MAPK11 MTOR RHEB PMC8091816__F4 Sulforaphane suppresses lipopolysaccharide‐ and Pam3CysSerLys4‐mediated inflammation in chronic obstructive pulmonary disease via toll‐like receptors TLR4 IRAK4 MYD88 TIRAP PMC8174708__F1 Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies CTH MTRR PSPH ASL PMC5596436__F7 Selected microRNA-target (cell cycle pathways) interaction data CDC6 CDK2 SMC3 MDM2 SAE1 CDC2 CDK7 PCNA SKP2 MYT1 PMC7519685__F4 Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? BCL2 TNF BAX PMC1933372__F3 RAN regulation pathway constituents exhibiting abundance changes, with a figure adapted from the GeneGo MetaCore database RANBP1 RCC1 RAN RANBP2 OTP SUMO1 PMC8789115__F5 Graphlet adjacency captures centrality of cancer driver genes in the FSAHF pathway HMGA2 HIRA UBN1 H1-0 EP400 CABIN1 RB1 HMGA1 PMC7795059__F1 Scheme illustrating the diverse autophagic pathways in cancer cells ULK1 ATG12 ATG3 ATG101 ULK2 ATG10 PMC9578877__F12 Ageing-Associated Transcriptomic Alterations in Peri-Implantitis Pathology: A Bioinformatic Study FGF21 EGF HGF TRADD INS ALOX5AP MTOR POR TXN CBFB INSR FOXP3 FGF23 APP JUN GZMK SDHC HOXA9 PDGFRA AREG FOS IGF2 MAP3K7 VEGFA FGFR3 GATA2 HEL-S-162eP IKBKB VEGFC MAX NFKB2 ERBB2 RELA TF CYCS PMC11762533__F4 Effect of aberrant activation of the HGF/c-MET signaling pathway on PD-L1 expression in various tumors: increased PD-L1 expression in NSCLC by activating the downstream pathway PI3K-AKT-mTOR STAT1 MACC1 HGF CMTM6 STAT4 MTOR PMC7970325__F8 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular cancer (FC) KAT5 CARM1 PALB2 SMUG1 FANCD2 TDG ATF2 NBN CREB1 POLL SERPINB5 UBE2T UNG CDK6 HES1 SIAH1 POLE PERP MBD4 WEE1 MDM2 ZMAT3 ARFGEF2 RAD50 RAD51 SP1 H2AX FDXR STEAP3 AREG IRF9 WDR48 CD82 TP63 BRIP1 MDC1 TLK1 TOP3A CARD16 PRH2 LIG1 RAD9A MRE11A CREB3 CDKN1A BRCA2 CDK2 RASGRF1 PPM1D SESN1 ATR GTSE1 SIRT1 PCNA CDC42 HIPK2 SFN BLM CDKN2D EGFR PTEN GPS2 RMI2 NEIL1 FEN1 CHEK2 ATM ATF4 UNK CDK4 DDX5 BAX HMGB1 NEIL2 RPRM NEIL3 DROSHA RMI1 MPG PMS2 FAN1 CREBBP EP300 PIDD1 FANCM FANCL MUTYH FANCA TRAF2 FANCB DYRK2 FANCE FANCG USP1 PMC11762533__F2 Impact of HGF/c-MET Signaling Pathway on Immune-Suppressive Cells and Their Interactions: Immune-suppressive cells primarily include CAFs, TAMs, MDSCs, and Tregs HGF MSC ETV2 ETV4 FGF19 FGFR4 ARG1 CHI3L1 STAT3 PMC7185194__F6 Novel universal mechanism of immunosuppressive A151 ODN RICTOR MYC PDPK1 RHEB STAT3 PMC11762533__F3 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion HGF ARG1 STAT3 PMC6943888__F1 Regulation of D-secretase in neurodegenerative diseases BACE1 STAT1 SET APP SRPK2 BDNF PMC11762533__F1 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion HGF CRK STAT3 PMC7185194__F2 GGIN identified by IPA software EGR1 CREBBP EP300 FOXO3A IL2 JUN STAT3 PMC11274073__F11 Therapeutic Potential of Dalbergia pinnata (Lour.) Prain Essential Oil in Alzheimer’s Disease: EEG Signal Analysis In Vivo, SH-SY5Y Cell Model In Vitro, and Network Pharmacology STAT1 STAT4 TYK2 IL6 IL6R STAT3 PMC9646457__F7 Myeloid checkpoints for cancer immunotherapy LILRB2 LILRB4 LILRB1 SRC B2M ARG1 APOE PMC2801257__F1 Signaling through the Lymphocyte receptor induces a novel regulatory motif for MAP kinase activation BTK BCR BASH CD22 LYN GRB2 SYK PTEN CD19 PMC9110840__F1 Advances in the Study of the Ubiquitin-Editing Enzyme A20 TRADD TRAF5 ZNF7 TRAF6 MYD88 TNF TRAF2 IL1B PMC5421515__F1 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis NLRP3 IGF1 VCAM1 ATF2 KLF2 TNF MTOR TGFB1 IL1B PMC6279936__F1 Processes of liver fibrosis progression and regression during human hepatosplenic schistosomiasis TH HMGB1 EGF IL4 PMC5421515__F2 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis TSC2 ULK1 TSC1 SQSTM1 APOL6 ATG101 MTOR RHEB TRPV1 PMC5421515__F3 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis TIGAR ULK1 FOXO3A BNIP3 MTOR SMAD1 DKFZp781O1323 PMC6626370__F2 Convergent inflammatory signaling through NFKB potentiates BRD4-dependent transcription of VI mediators, a result suppressed by apabetalone HMGB1 CCR2 TRADD BRD4 PMC6651063__F6 DE mRNA corresponding genes in the cultivar “Huoche” under heat stress PRR9 FER ELF3 PRR7 PRR3 PMC4429650__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis COX2 IL16 VCAM1 CRP TF PMC7185565__F2A Emerging Themes in PDZ Domain Signaling TIAM1 DAAM1 PATJ LRP5 CASK SHANK3 PICK1 ROR2 RHO PMC5739098__F8 Proposed model of changes in epigenetic status before and after establishing hiONs from hiPSCs and epigenetic silencing by hyperglycemia in orexin neurons GNE OGA OGT GC SIRT1 PMC5145083__F9 Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats MAS1 ACE2 PMC7807718__F6 Scheme summarizing the inhibition of H2O2-induced oxidant injury by FPNP via the up-regulation of antioxidant enzymes and TGFB/Smad pathway SMAD2 FH PMC9481960__F1 Knowledge-guided deep learning models of drug toxicity improve interpretation EGFR SRC TOX HDAC1 PMC6635557__F3 Schematic model of AngII-induced and mechanical stress-induced signaling pathway in vascular smooth muscle caveolae CAV3 EGFR PMC12182306__F12 Scheme highlighting the main findings of the study FGF21 AHR CX3CL1 PMC2574839__F2 Androgen synthesis pathway and therapeutic targets HSD3B1 HSD3B2 SRD5A2 PMC3726398__F2 Reconstructing the interactions among different modules of the MAPK pathway EGF SHE PMC4104784__F5 RNA-seq upregulation of energy metabolism gene expression SDHC CS NDUFV2 ENO1 UQCRC2 HEL-S-32 HEL-S-68p HEL-S-162eP HEL-S-49 UQCRC1 PDHA1 ACO2 ADA SUCLA2 PMC5144662__F6 T-cell receptor (TCR) signaling pathway LAT2 PAK4 FYN IL2 CDK4 PTPN6 IL4 CSF2 CD3G JUN ICOS CD3E CD3D NFATC1 FOS ARHA CTLA4 HRAS IL5 CBL IKBKB NFATC2 NFKB2 LCK GRAP2 ZAP70 GRB2 MAP3K14 LAT PMC3492937__F5 Stem cell pathways analysis for label-retaining cancer cell (LRCC) FGF4 CSNK2A1 WNT1 GSK3B RB1 GPR49 SOX17 CCND2 BMP4 FGFR1 FOXN1 BMP1 SOX2 DTX1 BMP2 DTX2 BMP7 UTF1 DVL1 LEF1 KLF4 CXCL12 SMAD1 MME DKFZp781O1323 NEUROG2 PMC8392691__F2 Renin–Angiotensin System in the Tumor Microenvironment of Glioblastoma AXIN2 MTOR ATR ACE2 PMC8657427__F2 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches BAD CD44 STAT3 PMC7338450__F2 GA12/13 signaling in metabolic diseases ROCK2 ARHA USP22 SIRT1 PMC12093937__F4 Drug targeting on skin cancer stem cell niche APC SHH SRC SMO MTOR PAX3 STAT3 PMC4385444__F1 Disease implications of the Hippo/YAP pathway TEAD3 AMOT NF2 VGLL4 TEAD4 LATS1 RHO LATS2 TEAD2 PMC7338450__F4 GA12/13 signaling in metabolic diseases VIT ATG12 NOTCH1 HAS2 ATG14 PMC8580835__F2 Host cell-intrinsic innate immune recognition of SARS-CoV-2 TBK1 STAT1 ISG15 STAT2 RAE1 NUP98 IRF3 KPNA1 MAVS SOCS1 PMC8560708__F3 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma PLK1 ATM RAD51 ATR TOP2A AURKA ARID1A PMC8560708__F1 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma ATM XPC RAD51 ATR PCNA PMC10669528__F4 Process of GSDMD in the pathogenesis of systemic onfection CD14 ACE2 AIM2 TF GSDMD PMC4826038__F3 Serpinin/pGlu-serpinin formation, its signaling pathway and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells CGA SP1 PMC11956425__F5 CXCR3/PLC/IP3/IP3R signaling pathway stimulated by PT CXCR3 GLA CFTR IFNG PMC4243952__F2 Impact of cellobiose on central carbon metabolism, amino acid biosynthesis and thiamine biosynthesis of Saccharomyces cerevisiae PDX1 PCK1 FBP1 ENO1 tal-1 HEL60 HEL-S-32 NDE1 MDH2 HEL-S-68p HEL-S-49 HEL-S-26 ARG2 ACO2 CYC1 ENO2 GLG1 GPD2 CDT1 ARG1 GPD1 PMC8392407__F1 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options IGF1R IGF1 IGF2 EPHA2 EPHB4 TF PMC8392407__F2 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options IGF1R IGF1 IGF2 LATS1 LATS2 TF PMC12093937__F1 Niche for normal and cancer skin stem cells TCF3 PMC12093937__F2 Core signaling pathways in skin stem cell niche APC SHH SRC LATS1 MTOR LATS2 STAT3 PMC7236211__F1 Pathway engineering strategy for succinate production in S CIT MAL SDHB PMC7443482__F3 Biosynthesis, transport, and roles of the coenzyme thiamine diphosphate in the model plant Arabidopsis PDC NCS1 PMC12093937__F3 Signaling network in skin cancer stem cell niche TCF3 APC GSK3B LATS1 MTOR PAX3 LATS2 TWIST1 PTCH1 SRC SHH SMO STAT3 PMC6586801__F2 Hypoxia signaling in human diseases and therapeutic targets ADORA2A ADORA2B ADA PMC3193400__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets MT3 RELA GPX1 RELB CYP2E1 PMC9240796__AF1 Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway BNIP3 HIF1A PMC4742390__F2 BMI1 regulates BCSC WNT1 BMI1 DKK1 PMC4350683__F6 Regulation of sonic hedgehog expression by integrin B1 and epidermal growth factor receptor in intestinal epithelium BMP2 EGFR SMO BMP4 PMC3668831__F1 Iron regulation by hepcidin BMP6 SMAD4 HFE SMAD1 STAT3 PMC8657427__F7 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches CS FASN CD36 HEL-S-5 GLS PMC6410669__F2 Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives CDK2 CDK4 PTEN MTOR CDK6 BAX PMC9437626__F2 Therapeutic targets by traditional Chinese medicine for ischemia-reperfusion injury induced apoptosis on cardiovascular and cerebrovascular diseases TRADD TNF BAX PMC7463953__F2 Putative target gene interaction network graph generated using Ingenuity Pathway Analysis of miR-34 and miR-181 family miRNAs nodes within a simulated cell PNOC ADA PMC7565866__F3 Micronutrients in one-carbon (1C) metabolism and DNA methylation HEL-S-61p PMC7275785__F1 Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation GRB2 PTEN RAC1 MTOR HES1 PMC5746039__F6 Glycolysis and its branching pathways HEL-S-133P HK2 HEL-S-281 PMC3831618__F2 Fe(II)-dependent, uridine-5′-monophosphate Alpha-ketoglutarate dioxygenases in the synthesis of 5′-modified nucleosides HP LIPK LIPN PMC11144369__F1 Outlines of the AhR signaling pathway COX2 AIP AHRR AHR CYP1B1 SRC CYP1A2 NQO1 PMC8006404__F7 Proposed mechanism about excessive caffeine intake-disturbed differentiation of myogenic progenitors through retinoic acid (RA) signaling pathway MYF5 PAX7 MYH7B PMC11144369__F2 FICZ-induced, AhR-mediated skin carcinogenesis from UV radiation AIP AHR EGFR CYP1A1 PMC8790316__F3 Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic Strategies TH IL1A PC APC VWF TF PMC3751776__F2 BTK signaling pathway BASH LYN SYK STAT3 PMC3745216__F3 TGFB signalling pathway BTRC KEAP1 SMAD4 SKP1 RBX1 PMC10740823__F9 Graphical abstract of the mechanism SMAD2 COL1A2 SMAD4 PMC6233116__F7 Tbx5 is required for a mesoderm–endoderm bidirectional signaling loop for cardiopulmonary development SHH TBX5 WNT2B PMC6897284__F3 Epigenetic regulation of miR-126 by metabolic changes in malignant mesothelioma IGF1 PARP1 ACLY IRS1 SIRT1 PMC9407090__F1 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure SELPLG ITGB8 SELP ITGA4 CD80 SELE SELL MADCAM1 F11R PMC9407090__F2 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure GNA11 ITPR2 PLCB2 PRKCE MAP2K1 TPR MAPK1 GNAL GRIA2 PLCB1 PMC5949883__F2 Network of metabolic pathways that regulate leukemia TSC2 TSC1 MYC PTEN PMC2758708__F2 Diagrammatic representation of non-canonical Wnt signalling in a mammalian cell SMURF2 PTK7 DVL2 SFRP1 ARHA CELSR1 VANGL1 SMURF1 SFRP5 DVL3 CTHRC1 DVL1 PMC7564482__F1 Folate-homocysteine metabolism pathway and possible causes of folate deficiency HEL-S-182mP MTR DHFR MTRR PMC7862610__F6 Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population CS CRP TNF PMC7589139__F5 The proposed molecular mechanism of glucose-6-phosphate dehydrogenase (G6PD) deficiency in human aortic endothelium and monocytes VCAM1 TNF PMC3179812__F6 Stem Cell Marker (Nanog) and Stat-3 Signaling Promote MicroRNA-21 Expression and Chemoresistance in Hyaluronan/CD44-activated Head and Neck Squamous Cell Carcinoma Cells CD44 STAT3 PMC11964643__F2 Effector-mediated inflammation PAK1 NLRC4 TRIM56 TRAF6 TRIM65 CDC42 STAT3 PMC6386537__F3 Immunologic Pathways in Protective versus Maladaptive Host Responses CCR2 IL3RA CAP1 DAO FLNA MYC CCL21 TRAF6 GCK CXCL3 TPO CCL2 POR CCR1 TNFSF6 KDR CNTFR GHR CCR7 CCL25 FOS LTB TRO TNF IL23R TSLP EDAR LEP MAX IFNK GRB2 BDNF MPL XCL2 TAB3 EGF GHB2 IL26 IL18 AMH SF1 IL2 ECSIT JUN CD14 MOS BMP2 LIF CCR4 IL24 CXCL2 FLT3LG TNLG7C PRL CNTF NLK CXCR3 LTA CYC1 IL-21 TRAF2 OSM INHBB LTBR INHBA INHBE PMC8306345__F6 Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis NLRP3 TLR4 IL6 CCL2 MYD88 TNF IL1B GSDMD PMC3815439__F13 MicroRNAs: molecular features and role in cancer DIABLO FADD SIRT1 BAX PMC2679989__F1 Function of Nod-like Receptors in Microbial Recognition and Host Defense CARD9 JUN NOD2 TAB3 PMC8758217__F1 Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients KEAP1 ATF4 EIF2A ATF3 RBX1 PMC2408406__F1 Microvasculature in the pathogenesis of inflammatory bowel disease TLR5 TLR4 PC CD40 PMC8671602__F4 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity NLRP3 NLRP6 DDX3X DDX19A IRF3 DHX15 IL1B MAVS PMC7790571__F3 KEGG pathway: map04064 NGF TRADD RELB LTB MIP TRIM25 EDAR COX2 LTA BCR ATM BASH CYLD LYN LAT TIRAP PMC8671602__F2 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity TRAF3 TRAF6 IRF3 DHX15 DDX24 DHX29 DDX46 DDX56 DDX60L DDX39B DDX5 RNF39 MAVS SNRNP200 PMC11782130__F7 Location and role of Gtl2-Dio3 target genes in the Wnt and PI3K-Akt signaling pathway PIK3R1 EFNA1 EGFR DKK2 FGFR2 OSMR COL4A6 BCR NGFR TLE4 opn GHR SFRP1 AXIN2 LAMA5 SHISA6 FGF7 ANGPT2 RELN SFRP4 PDGFRA LRP5 LRP6 ARHA IFNAR2 IRS1 PIK3R5 ANGPT1 PRKCB IGF1 EFNA5 SHISA4 VTN STM7 SYK EPHA2 MYLK PMC8671602__F3 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity CGAS DDX60L IRF9 DHX30 DHX36 DDX41 IRF3 TYK2 IFNAR2 IFNAR1 IFI16 PMC5997150__F2 Requirement of the Arf6-based mesenchymal pathway in both mesenchymal-type and amoeboid-type cancer invasion EGF HGF ARHA RAC1 LPA ARF6 EPB41L5 PMC8671602__F1 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity TBK1 TLR9 IRF7 DDX1 TRAF3 TRAF6 DHX36 IRF3 MYD88 TLR1 DDX24 TLR3 TLR8 TLR7 TLR4 PMC8546001__F4 BMP signaling requirements in mucociliary cell types SMAD4 SMAD1 DKFZp781O1323 PMC8978634__F6 Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome NLRP3 IL1B GSDMD PMC3013041__F5 Relationship between transcription factors and their regulatory factors GSK3B JUND JUNB ELF4 TF PMC9130463__F3 Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases SMAD4 GATA3 TRPV1 PMC5860983__F11 Human binge alcohol intake inhibits TLR4-MyD88 and TLR4-TRIF responses but not TLR3-TRIF pathway: HspA1A and PP1 play selective regulatory roles TLR4 IRF3 MYD88 TNF TLR3 PMC11808218__F11 Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway GPX4 SLC7A11 TFRC BDNF PMC12229020__F1 ECM deposition-induced inflammation and fibrosis CORT NLRP3 JUN SIRT1 PMC6010831__F9 Proposed model of the mechanism that links mitochondrial dysfunction and insulin resistance in non‐alcoholic steatohepatitis MFN2 NRF1 TG TFAM INSR PMC7347220__F5 Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells CDH23 SOCS3 CMPK2 HSD11B1 CXCL3 CCL2 OAS3 DACT2 CCR7 SMOC1 APOE IRF7 STAT2 TNFRSF1B PDE4B IGFBP4 COXFA4L2 PARP10 HEL-S-134P CLEC3B POLG HMFT1766 MX1 ISG15 DTX3L SP110 OAS1 CYP26B1 OAS2 CXCL6 HEL-S-75 CFB ADAMTS15 ENPP2 TNFSF10 GBP4 NGF LGALS9 APOC1 RNF213 FGFR4 RTP4 CRLF1 USP18 OASL G0S2 MPZ THOC6 CCL13 AMPH RSAD2 UNC93B1 DDIT4 IFI44 ISG20 KCNG2 PHYHD1 HELZ2 SAMD11 PDGFRL OLFM2 KCNE4 CYP4X1 SLC15A3 TLE2 RASL10B IFIT1 CPZ HEL163 HEL-S-62p PF4V1 PLEKHG3 BATF2 AP3B2 SMTNL2 TRIM21 COLEC11 RAB20 HES4 CA11 PODN THEMIS2 CEBPD INMT NGFR GBP2 ELANE CHST7 CXCL2 PISD TRIM25 IGFBP5 IDO1 SPOCK2 RGMA TXNIP IFI35 PMC8436873__F1 Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein NLRP3 CD163 CYP11A1 STAR PMC8382889__F1 Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases CD9 CD63 EGFR EDIL3 HMFT1766 CD81 CD24 PMC7408589__F12 Influence of X-rays (7 Gy) on regulation of the p53 pathway (according to the Mus musculus p53 signaling pathway available at https://www.genome.jp/kegg/) in mESCs in presence of LIF (+LIF) and absence of LIF (-LIF) CASP3 TSC2 SIAH1 PERP ATM LIF MDM2 CASP9 PTEN MTOR ATR RFWD2 PMC11037034__F3 Novel milestones for early esophageal carcinoma: From bench to bed TLR4 SMAD2 MYD88 PMC12229020__F2 Impaired ECM degradation in PCOS COX2 AHR ATF4 GC BCL2 BAX PMC12229020__F3 Altered mechanical forces in ECM remodeling FOXO3A GC PTEN PMC5791855__F1 Tuning the depth of quiescence for cancer therapy CDK2 MYC CCND1 CDK4 RB1 CDK6 CCNE1 PMC7322352__F4 MAPK Signaling PathwayGenes in the pathway are colored based on their expression in TN tumors NF1 CD14 NLK MAX TRADD FLNA GRB2 ECSIT RAF1 TNF TRAF2 PMC2214701__F3 Building bone to reverse osteoporosis and repair fractures APC GSK3B LRP5 LRP6 SFRP1 DKK1 PMC7322352__F5 MAPK Endogenous RNA NetworkThis figure shows the network of interacting protein-coding mRNAs and non-coding microRNAs in the MAPK singling pathway BAD HGF BRAF IRAK1 MYC TGFBR2 ATF1 CACNA2D1 STAT1 NF1 SRC MOS PDGFRA NFATC1 HEL-S-28 DOCK1 RAC1 EIF4E CRK ANGPT1 IGF1 RASGRF1 DUSP16 GRB2 PXN TGFB1 STAT3 PMC4596691__F4 Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNG Regulation XCR1 EPOR EPO RELT FLT4 CXCL3 TNFSF6 BMPR2 CSF1R KDR ACVR2A CLCF1 CNTFR GHR CCR7 CTF1 CCL19 TNLG5A CSF2RA INHBC LTB VEGFA IL8RB IL25 TNF TSLP THPO EDAR LEP CD27 CXCR4 IL2RG CCL20 GH1 NOA1 CCL22 MPL TGFB1 CXCL1 EGF GHB2 IFNA1 CCR3 HGF EGFR CSF3R PPBP IL26 CCR10 NGFR KITLG LEPR IL2RB KIT BMP2 BMP7 IL24 CXCL2 IFNB1 TNLG7C PRL CNTF CXCR3 BMPR1A PRLR IL23A FLT3 IL20 VEGFB INHBB LTBR INHBA PMC9515549__F1 Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17 LRPPRC KLF6 CDK6 STAT3 PMC9553755__F6 Exploring Potential Biomarkers, Ferroptosis Mechanisms, and Therapeutic Targets Associated with Cutaneous Squamous Cell Carcinoma via Integrated Transcriptomic Analysis TH AURKA PMC9700862__F8 Overall mechanisms involved in CNNM4 overexpression caused by APAP overdose ATF4 TNF XBP1 CNNM4 PMC5355168__F1 Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma INPP4B SOCS1 STAT3 PMC5467070__F1 Lipopolysaccharide induces apoptosis of hepatocytes via the TLR4/PI3K/Akt/GSK-3B pathway CD14 TLR4 GSK3B LBP BAX PMC7410168__F5 Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control TBK1 IL21R PLSCR1 CGAS IFNA4 IFITM1 USP18 MX1 IFNG DTX3L ISG15 OAS1 IFI16 ICOS RUNX3 STAT2 IRF9 CXCR5 IRF3 CTSZ BCL6 STAT4 CD40 TYK2 CD80 SOCS1 MAVS IFIT1 STAT3 PMC2721285__F1 RAS/MAP kinase signaling pathway KIT BRAF PMC8894702__F2 miR-1269a and miR-1269b: Emerging Carcinogenic Genes of the miR-1269 Family CASP3 HOXD10 HTT CASP9 PTEN RASSF9 SOX4 CDC40 PMC8618211__F2 Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected HEL-S-62p CLC NGF C4B_2 CIC TNF PMC6964037__F4 Functional network analysis of I-MDSCs in CRC microenvironment NLK INVS STOM APC SOST NOTUM GRB2 SKP1 ARHA RYK WIF1 STAT3 PMC9308790__F8 Molecular mechanisms underlying TRIM25-regulated DOX-induced cardiotoxicity TRIM25 XBP1 PMC6290882__F1 Hedgehog signaling pathway SUFU PTCH1 SMO PMC5865869__F3 Differentially-expressed gene pathway network generated using CluePedia RHO MYD88 TNF TLR3 PMC6162445__F3 Mechanism of GPCR bias agonism involves insulin receptor activation EBP MMP9 ATR IRS1 NMBR PMC2435603__F8 Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways NGF GRB2 CDC42 PMC3265821__F1 Change in RAF isoform usage in response to a RAS mutation BRAF GRB2 PMC6121429__F3 Insulin signaling IRS1 PMC2441985__F3 The regulation of the insulin signaling pathway by miRNA cluster mmu–mir-183–96–182 GRB2 IRS1 SHC1 PMC9686289__F8 Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses MBD3 STAT1 PLXNC1 HSDL2 IGSF6 AGO4 BSDC1 GPR137B INPP5D GYG1 GDF11 PMC12176804__F5 IL-17 signaling pathway was enriched in the BD vs MMP3 COX2 S100A10 MMP9 S100A8 CCL20 CCL7 IL6 CCL2 S100A9 S100A7 PMC7758031__F1 Regulatory mechanisms of DELLA stability by PTMs SKP1 RBX1 DDB1 RFWD2 PMC5876660__F3 KSHV regulation of the TLR signaling pathway TBK1 TLR8 TLR7 TANK TLR4 TLR9 IRAK1 TRAF3 TRAF6 IRF3 MYD88 PMC9449932__F2 Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2 TH TJP1 IRF7 IRF9 TRAF6 RNF2 MYD88 MX2 MX1 ISG15 OAS2 TYK2 TJP3 GJB1 JUN IRF2 MAVS PMC7790228__F11 TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response TBK1 TFG TRAF3 CHAD IRF3 MTOR MAVS RHEB PMC11984404__F9 Schematic diagram regarding key parts of this study CX3CR1 LCN2 JAK3 STAT3 PMC7843579__F8 Schematic diagram illustrating the global view of transcriptional changes in MPTP/p-induced progressive PD mice model TH SERPIND1 DRD2 MTOR EN1 ADM PMC5474932__F1 Integrated Transcriptomic and Metabolomic Analysis of Five Panax ginseng Cultivars Reveals the Dynamics of Ginsenoside Biosynthesis MVK IPMK IPP ARAF MVP PMC9267017__F1 Novel Drugs with High Efficacy against Tumor Angiogenesis FYN RHO CDC42 PMC11016256__F1 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis HMGA2 SMAD2 SMAD4 SIX1 TGFBI PMC5440471__F3 Manipulation strategies of neutrophils and the immune system by P IL16 TNF IL1B PMC5808955__F1 Schematic overview of the effects of Saccharomyces boulardii CNCM I-745 on enzymes within the small intestine PTS DAO SI GRB2 MGA PMC9403334__F3 Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint TRPC3 MCU PMC3618249__F2 Single drug simulation result on T2D model GRB14 AgRP PTPN11 GRB2 SOS1 HRAS PPARG SHC1 IRS1 INSR CBL PMC5270220__F1 APP cleavage pathways BACE1 ADAM9 BACE2 APP ADAM10 PMC11016256__F2 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis ITGA6 SMAD2 PDK2 PTEN PMC11016256__F3 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis HMGB1 RELA RELB PMC3618249__F3 combination drug simulation result on T2D model GRB14 AgRP SOST GRB2 PTPN11 HRAS PPARG INSR PMC11016256__F4 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis HMGA2 HMGB1 ITGA6 SMO PTEN PMC5116470__F1 Some of the known pathways linking DDR to autophagy TSC2 ULK1 ATM PTEN MTOR DEPTOR PMC3058407__F1 Antiviral apoptotic pathway is mediated by IRF-3 and Bax TBK1 TLR4 TRAF3 TRAF6 IRF3 TRAF2 NOD2 TLR3 BAX PMC3612776__F1 Pathways affected in monogenic hypertensive disease KLHL3 WNK1 DCT NR3C2 WNK2 PMC8136436__F1 Biogenesis and clearance of H2S and reactive sulfur species SQOR ETHE1 PMC4832112__F1 Necroptotic pathway TRADD CYLD MAP3K7IP1 TRAF2 FADD TLR3 MLKL PMC8745152__F9 Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling FGF23 FGFR1 ORAI1 PMC9563553__F1 Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study ARHA LATS1 LATS2 HMGCR PMC5903986__F1 Astrocyte glycogen and lactate: new insights into learning and memory mechanisms SRC MTOR BDNF PSD PMC6003946__F12 SLIT2-ROBO1/ROBO2 and the CDC42-RAFs-ERK1/2 MAPK cascade PAK1 SRGAP1 CYP11A1 ROBO1 ROBO2 FSHR SLIT2 STAR PMC8914507__F2 Contributions of glycolytic intermediates and glutamine to collagen protein synthesis PSAT1 PSPH HEL-S-51e PHGDH GLS PMC6769855__F1 Simple depiction of signaling pathways for the activation of classical NLRP3 inflammasome (canonical and non-canonical) and alternative inflammasome NLRP3 RIPK1 TLR4 CASP8 IL1B FADD PMC3417373__F4 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis BAD EGR2 BNIP3L PTEN FADD FGFR2 BAX PMC3058986__F8 Possible role of RACK1 in VEGF/Flt1-induced cell migration PIGF VEGFA RAC1 VEGFB PMC8638980__F5 Association of air pollution and homocysteine with global DNA methylation: A population-based study from North India IL6 IL1B PMC9084887__F2 Advances in the Structural and Physiological Functions of SHARPIN SHARPIN CD40 MYD88 TRAF2 PMC6461947__F6 Current understanding of SHON and ERA signalling SMAD2 SMAD4 SP1 PMC5555159__F24 Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products PIGF PIGC PIGH PIGM PIGA PIGN PIGL PMC3734592__F5 Ingenuity analysis of representative accumulated proteins in response to inactivation of CRL/SCF system ABCC3 SMAD4 RB1 CCND3 HMOX1 CCNE1 THRSP WEE1 MDM2 CDK4 SIN3A FASN MAFG FOXO3A MAFF GCLC CDKN1B NFE2L2 NRG1 CDKN1A MAX SUV39H1 SP3 SRXN1 STAT3 PMC9162151__F3 Pathogenesis and treatment of multiple myeloma BAD IGF1 GSK3B MTOR PMC10041518__F1 Biosynthetic pathways for pyrimidine and purine nucleotides, relevant inhibitors and oncogenic regulators CDA UCK2 DCTD UMPS UCK1 ATM ADSL DHFR ADA IMPDH1 IMPDH2 CAD DHODH ATR PNP PMC7915224__F6A Ins and Outs of RAS Effector Complexes E2F4 E2F6 GSK3B MYC E2F5 RHO MTOR E2F3 CDK6 E2F7 ATM CDK2 E2F2 UNK CDK4 ATR FADD ERC1 PMC10041518__F4 Supraphysiological GTP abundance promotes metastasis through the activation of RHO-family GTPases GMPR IMPDH1 IMPDH2 RHO CDC42 PMC10041518__F5 Hyperactive nucleotide synthesis confers resistance to a range of therapeutic interventions GPX4 UMPS CAD HIF1A DHODH PMC10041518__F2 Nucleotides fuel cancer cell growth and proliferation HEL-S-62p ME1 CDA OGT DHFR MYC HIF1A DHODH PMC10041518__F3 Altered nucleoside handling facilitates cancer cell immune evasion ADSL GMPR IMPDH1 IMPDH2 PNP PMC4818674__F1 Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration ARHA PTEN MTOR PMC7223478__F4 Several major mechanisms that have been implicated in vascular aging EDN1 GC ARHA RHO SEMA3G PMC6195654__F11 BMP signaling pathway overlapped with the results of the comparison BAVc vs BMP6 BMP3 RUNX2 PITX2 SMAD6 SMAD4 BMP7 SOSTDC1 MAP3K7IP1 BMP4 FST NOG GREM1 TLX2 CAMK4 NKX2-5 BMP8A BMP5 SMAD1 JUN DKFZp781O1323 PMC2754156__F3 LPS signal transduction via the MyD88-dependent pathway CD14 LBP TRAF6 IRAK4 MYD88 TIRAP PMC2754156__F4 LPS signal transduction via the MyD88-independent pathway CD14 LBP TRAF6 PMC6195654__F10 Hepatic fibrosis/hepatic stellate cell activation canonical pathway EGF HGF ACTA2 SMAD2 EGFR CCL21 SMAD4 COL1A1 IFNG RARB MMP2 CXCL9 IL4 CSF1 IL10RA BAX PMC7563523__F1 Proteins, non-coding RNAs, and signaling pathway regulators involved in the lack of response of colorectal adenocarcinoma to pharmacological treatment BAD SNAI1 EGFR GPR49 CYP1A2 ZEB2 SLC19A1 BAX PIGF CD47 CES2 SOX2 APC VEGFA CD44 XPC EIF4E HEL-S-21 MPG ATP7B CYP3A4 TWIST1 ERBB2 TYMS ERCC1 FADD PMC4762141__F5 Different gene expressions in regulation of actin cytoskeleton pathway in AuNR-treated MDA-MB-231 cells LIMK2 BRAF CSK WASF2 BAIAP2 APC INS GNA13 PAK4 MAP2K2 ARHA ABI2 WAS RRAS2 CRK GNG12 DIAPH2 F2 HEL114 PXN PMC7797663__F1 Central pathway of cancer cachexia involving GDF15 and GFRAL with RET proto-oncogene as a coreceptor RET GDF15 NTS GFRAL PMC6089887__F3 Metabolic pathway map in the plasma comparing common bottlenose dolphins (n = 3, blue columns) and beagle dogs (n = 3, red columns) MIA DAP ACD OTP PMC6136406__F8 Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factorKB/p65 pathway in RAW264.7 macrophages and in COPD mice IL1B SIRT1 PMC4762141__F4 Differential gene expression in glycolysis/gluconeogenesis pathway in AuNR-treated MDA-MB-231 cells DLAT HEL-S-162eP PMC7839966__F5 Comprehensive analysis of the lncRNA-associated competing triplets PMC4779258__F6 Ozone-induced lung inflammation and role of IL-6 signaling pathway: ozone-associated lung inflammation is primarily driven by lipid ozonation products (LOP) and generation of free radicals primarily in lung epithelial cells IL6 IL6R STAT3 PMC12207060__F3 Schematic representation illustrates the molecular mechanism regulating MTNR1A, NEAT1 and AANAT gene expression in renal TECs HNRNPL MTNR1A EXOSC10 PITX1 PER2 AANAT PMC6832198__F4 Intracellular molecular alterations and their effects on tumour microenvironment immune activity KIT PTEN MTOR PMC8396295__F7 Gene-Metabolite Network Analysis Revealed Tissue-Specific Accumulation of Therapeutic Metabolites in Mallotus japonicus CAD PMC12207060__F1 Diagrammatic representation of the melatonin synthesis pathway and melatonin receptor-mediated cell signaling DDC MTNR1A AANAT MTNR1B PMC8361364__F1 Interconnections Between Somatic and Ovarian Aging in Murine Models KIT PTEN MTOR PMC8550885__F2 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan TSC2 RICTOR TSC1 TNF RHEB PMC5716761__F7 DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer TSC1 DEK MTOR PMC8123408__F2 Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis TPH1 CDH2 PMC8550885__F3 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan TLR8 TLR7 TLR4 TLR9 APC CD80 MTOR PMC7442594__F7 Schematic proposed model of HDAC10 in KRAS-driven lung cancer development HDAC10 CD44 SOX9 PMC5415769__F3 RICTOR is upstream of multiple canonical pathways NDUFA7 ATP6V0D1 ATP6V1C1 UQCRC2 COX7A2 TCIRG1 RICTOR UQCRC1 NDUFB3 C6 COX6B1 ATP6V1A NDUFS5 SDHA PSMC1 BAX PMC5415769__F2 Canonical pathways form groups for each individual protein OXCT1 MYC MAPK14 ATP6V0D1 PLCG2 ATP6V1C1 COX7A2 HSD17B10 MYO1E HEL-S-32 IFNG UQCRC1 INPP5D CCT7 COX6B1 OGDH B2M SDHA SNRNP200 APOE ACTR2 GCLM TUBB SH3GLB1 PRPF40A UQCRC2 HLA-A RICTOR HEL-S-165mP ARPC2 ARPC3 NDUFB3 TGFB1 PNP CDC42 MYH9 DYNC1H1 HADHB PRPF3 MYL6 TLN1 RHO PLD4 MTOR INSR FCER1G IVD APP ATP6V1A PRPF8 LBR FTH1 LAMP2 NDUFA7 NR3C1 FTL HMGCL DBT HEL-S-21 ARPC5 NR1C1 TCIRG1 PTPRC TFEB HNRNPC PPIB PPARG ECHS1 SOCS1 STAT3 PMC2650010__F1 Akt-dependent and independent mechanisms of mTOR regulation in cancer TSC2 RICTOR PI3 TSC1 PTEN MTOR RHEB MLST8 PMC2650010__F2 Akt-dependent and independent mechanisms of mTOR regulation in cancer TSC2 TSC1 MAP4K3 MTOR RHEB MLST8 PMC2650010__F3 Akt-dependent and independent mechanisms of mTOR regulation in cancer TSC2 TSC1 MTOR RHEB MLST8 PMC4680051__F2 Metabolic networks placing mitochondria at the center of anabolic and bioenergetics pathways in cancer cells HEL-S-133P PHGDH PMC5629070__F6 Schematic representation of the proposed IR signal diversification by ligand-induced crosstalk with molecular partners DDR1 IGF2 IGFBP2 IGFBP6 MTOR PMC6115946__F8 miRNA regulatory pathway in the control of the protein synthesis through SIRT1—TSC:mTOR TSC2 TSC1 IGF1R IGF1 MTOR SIRT1 RHEB PMC4503878__F6 Schematic representation of the dual role of 25-HC in the sterol biosynthesis pathway and the IFN--regulated innate immune response using SBGN system (inset shows key) CH25H ATF3 HMGCR PMC9266903__F1 Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment GPX4 FACL4 HMOX1 PMC3738954__F4 Key signaling pathways modulated by WNV infection TBK1 TANK TRADD TRAF3 TRAF6 CCL5 MYD88 NOD2 MX1 STAT1 ISG15 OAS1 SRC CASP9 IRF-1 CASP8 IL1B CCL8 NLRP1 STAT2 IRF7 IRF9 IRF3 TRIP6 TNF CASP10 MAP3K7IP1 CASP3 MAPK6 TRAF2 FADD SOCS1 MAVS PMC8740226__F15 Effect of Chinese Herbal Medicine Mixture 919 Syrup on Regulation of the Ghrelin Pathway and Intestinal Microbiota in Rats With Non-alcoholic Fatty Liver Disease POMC GHSR NPY PMC3932252__F2 Autophagy is negatively regulated by the phosphatidylinositol 3-kinase (PI3 K)/Akt signaling pathway, which activates mammalian target of rapamycin (mTOR) in response to growth factors and also phosphorylates Beclin 1 ULK1 ATG12 ATG3 ATG101 UVRAG ATG10 MTOR DKFZp686F0183 RB1CC1 PMC2822937__F7 Downstream effectors of the ErbB receptor signalling pathway ERBB4 ERBB2 ERBB3 EGFR GRB2 PTEN PMC4306938__F9 Schematic presentation for araguspongine C-induced autophagic death in breast cancer cells EGF HGF MTOR PMC8896306__F4 Circadian rhythms and cancers: the intrinsic links and therapeutic potentials LATS1 LATS2 PMC2754915__F1 Schematic illustration of different pathways of glucose metabolism in cancer cells PDC HEL-S-133P FASN PMC12103767__F6 Proposed hippocampal signaling pathway altered by early amyloidosis HIVEP2 GSK3B NEUROD2 RCAN1 CREBBP IGF1 PPP3R1 LSR DAB1 PIANP APOE CAMKK2 IGFBPL1 PMC9130080__F45 Triclosan-induced neuroinflammation develops caspase-independent and TNFA signaling pathway associated necroptosis in Neuro-2a cells TRADD RIPK3 TRAF2 CASP8 FADD MLKL PMC3829196__F2 The p53-mediated apoptotic signaling pathways PERP ATM APAF1 ATR BAX PMC3565214__F1 Major oncogenic signaling pathway alterations in urothelial carcinoma TSC2 TSC1 FGFR3 PTEN MTOR PMC6031328__F2 Regulatory mechanisms for alternative splicing impact numerous components of the CME CLTB SNAP91 NUMB CLTA EPN2 FCHO1 FCHO2 SNX9 DNAJC6 ITSN2 EPN1 ITSN1 CLTC PMC6086351__F1 Small Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver ERBB2 EGFR RB1 PMC4593342__F1 Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy HOXB4 MSC PMC9001149__F10 Signaling pathway and molecular mechanisms underlying TLR/zVAD-induced autophagic cell necroptosis TBK1 STAT1 TLR4 IRF3 TYK2 MYD88 JAK1 TLR3 PMC2754915__F3 Signalling events which determine glucose utilization within the cell TIGAR SCO2 PTEN IRS1 PMC3532876__F2 Vicious spirals of repeating self-accelerating oxidative stress and dysregulated redox and information signaling as possible causes of type 2 diabetes PDX1 NOX4 TXNIP PRX MAFA PMC6800950__F4 SREBP pathway mediated NLRP3 inflammasome activation NLRP3 IL16 PMC3618452__F3 Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats GLRA2 CHKA CFH HTT FXN PMC4160369__F2 Molecular Approaches to Thyroid Cancer Diagnosis BRAF TSHR PTEN MTOR PMC6943935__F3 Noncanonical IL-17 signaling BCL10 LRIG1 EGFR CCL20 TRAF6 SYK SOS1 TRAF4 CARD14 PMC3583298__F7 Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation ATM IGF2 PMC5663620__F1 Novel strategies to prevent the development of multidrug resistance (MDR) in cancer ABCB1 BAX PMC10244677__F1 Integrated high-throughput analysis identifies super enhancers in metastatic castration-resistant prostate cancer NAV1 BCR TACC3 FKBP5 BRD4 PMC9158441__F7 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms HEL-S-30 MTOR HEL-S-133P HK2 PMC4658032__F8 MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NFKB Signaling Pathway Following Negative Regulation CD14 MFHAS1 MYD88 TNF PMC5786286__F5 5-HT2Asignaling pathways GRB2 SRC BCL2 BAX PMC6530392__F1 Sublytic C5b-9 promotes tumor growth and survival by activating several signaling pathways BAD JAK1 GAL FOXO1 STAT3 BAX PMC11804041__F11 SNHG involved in a serious of cellular biological role in EC RECK NOTCH1 MTOR BCL9 SOX4 PMC6533455__F1 Bone development and skeletal homeostasis SFRP4 LRP4 SOST LRP5 LRP6 DKK1 PMC3910515__F7 TGFB signaling at the BBB during acute peripheral inflammatory pain SMAD2 SMAD4 SMAD1 TGFB1 DKFZp781O1323 PMC8215365__F12 Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection CD14 TLR4 FOS JUN TLR3 NRK MAL PMC6697957__F5 Wnt signaling: a promising target for osteoarthritis therapy BMP2 SMAD2 APC COL1A2 LRP5 LRP6 DKK2 SMAD1 DKFZp781O1323 PMC9322890__F5 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) CASP3 APAF1 CASP9 SRC MTOR BAX PMC7786386__F4 p38-signaling in white adipose tissue browning UCP1 PPARGC1A ATF2 GC MAP3K7IP1 PMC9322890__F6 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) TRADD KEAP1 IRAK1 TRAF6 IRAK4 MYD88 MTOR CASP3 RIPK1 BCL10 CASP9 TRAF2 SIRT1 STAT3 BAX PMC6697957__F3 Wnt signaling: a promising target for osteoarthritis therapy RUNX2 BMP2 LRP5 LRP6 SMO ANXA6 SMAD1 DKFZp781O1323 SOX9 HES1 PMC6697957__F1 Wnt signaling: a promising target for osteoarthritis therapy MMP3 RUNX2 APC SOST LRP5 ACAN COL2A1 SOX6 SOX9 FRZB PMC8161352__F5 Endophytes: the novel sources for plant terpenoid biosynthesis F2 RB1 IPP PMC7600458__F8 Signaling pathways underlying the cooperative relationship between stearic acid and TNFA for MIP-1A/CCL3 production TLR4 TRADD IRAK1 TRAF6 IRF3 IRAK4 XPA MYD88 PMC3598692__F8 Toll-like receptor signaling pathway figure supplied by KEGG ] CD14 CTSK TRAF6 INTU IL6 TNF FADD TIRAP PMC3787652__F2 Differentiation and commitment of IL-17-producing T helper (TH)17 cells in the midpoint of other coacting cells in favor of and against the harboring individual CCR6 CCR4 CXCR5 IL23R FOXP3 STAT1 AHR STAT4 IL17RA RORA IRF4 GATA3 TF ICOS STAT3 PMC11022604__F1 Wnt/Beta-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target APC GSK3B LRP5 LRP6 PMC9232692__F2 Emerging roles of spliceosome in cancer and immunity U2AF1 SF1 U2AF2 PMC5569703__F1 Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility FCER1G CCL11 EPX MBP APC CD40 CD40LG TNF PMC9322890__F7 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) CASP3 KEAP1 SMAD2 GSK3B CASP9 PMC3243812__F8 Beta2-adrenergic receptor engagement on a B cell that will make IgE uses a unique signaling pathway to increase the level of IgE produced CD40 ADAM10 PMC6253933__F5 Roles of SIRT7 in cancer ZER1 SIRT7 SMAD4 CDC2 PMC7501977__F1 Underlying mechanism of mitophagy in influencing COPD with different phenotypes NLRP3 PINK1 LRRC2 OPTN MAVS MLKL PMC10879685__F2 NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy PLCG1 EGF VAV1 EGFR APC MYC PTEN MTOR STAT1 FGFR1 LCK GRB2 CD80 IRF-1 GATA3 STAT3 CDC42 PMC9331826__F1 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance DUSP4 ABCB1 PMC9331826__F3 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance DCLK1 EGFR AXL PMC11125956__F7 T helper 1 Activation Pathway CCR5 SOCS3 LGALS9 HAVCR2 MAP2K6 IFNG STAT1 IL18 IL2 GATA3 ICOS PRKCQ VAV1 KLRC1 HEL-S-92n IL6 CD8A IFNAR1 CXCR3 TBX21 TNFSF11 KLRD1 IL27 STAT4 GRB2 NFIL3 CD80 IL27RA SOCS1 IL18R1 STAT3 PMC11125956__F8 T helper 2 Activation Pathway CCR5 SOCS3 CCR3 CHD4 IL31 CCR8 CXCR6 CCR1 MAF IKZF1 TNFRSF4 BHLHE41 IL4 JUN ICOS RUNX3 PRKCQ VAV1 CCR4 S1PR1 IL24 TNLG2B TSLP TBX21 CXCR4 STAT4 IL33 GRB2 CD40 PTGDR2 TGFB1 PMC7764163__F2 Simplified canonical NFKB signaling pathway with its many deubiquitinating regulators and the molecular targets of those enzymes RIPK1 TRADD CYLD RELB TRAF2 TAB3 PMC5601171__F1 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy SOX2 FOXM1 SUFU APC PTCH1 GLI3 GSK3B SHH UST SMO ABCG2 PMC3239343__F2 Intracellular signalling during inflammation-induced osteoclastogenesis TRADD NFATC1 OSCAR TEC TRAF6 IL1R1 IRAK4 MYD88 TNF BTK TRAF5 SYK TRAF2 PMC5696218__F10 Verrucarin J inhibits ovarian cancer and targets cancer stem cells WNT1 NOTCH1 PMC4921457__F1 Mechanisms responsible for aldosterone synthesis in zona glomerulosa cells under normal physiological conditions and excess production in primary aldosteronism MC2R ARMC5 NACA KCNJ5 ATP2B3 CYP11B2 PMC4446054__F3 Top enriched network associated with BCa progression ANXA1 UBE2D3 VEGFA PTEN RB1 RCAN1 HDAC5 IGFBP5 IAPP ITGA2 BIRC2 CYLD F3 APP CCND1 MDK RPS23 PMC5601171__F5 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy EGF PTCH1 EGFR MYC SMO PTEN MTOR PMC5601171__F3 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy SOX2 FOXM1 PTCH1 GLI3 SHH SMO ABCG2 MTOR GLA PMC2952492__F1 Regulation of neo-vascularization by SDF-1 EPO CXCR4 VEGFA TPO PMC2774072__F7 Proposed consequences of impaired insulin signaling in AD brain and in the STZ-injected rat brain OGA OGT PTEN MTOR PMC8774031__F7 Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications RPLP2 RPL38 POLL MTOR POLI PMC8526300__F2 New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis ANXA1 GULP1 MEGF10 ABCA1 HEL-S-7 APOE PMC86511__F9 Common and distinct activities of TGFB and BMP in C2C12 cells RUNX2 SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC9479087__F2 Polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment SMOX SRM PAOX SLC3A2 SMS PMC6067831__F1 The HPA axis CORT CRH PMC7990797__F6 KEGG enrichment pathways of DEGs related to IL-17 signal pathway and cytokine–cytokine receptor interaction IL1A IL18 CSF3 IL23A CCL20 CCR7 MAPK14 IL17RA TRAF4 PMC7859776__F7 An illustrative model to show the proposed mechanism of miR-126-3p promoting sorafenib resistance in HCC SPRED1 PMC11839412__F1 The relationship between CD133, AKT, and MAPK signaling in cell cycle regulation (By Figdraw TSC2 EGFR GSK3B CCND1 CXCL3 PTEN MTOR PMC11839412__F2 Roles of WNT and Notch in CD133+cell cycle regulation (By Figdraw LEP APC MYC CCND1 HEL-S-53e EZH2 TRPM7 HES1 PMC12021630__F2 Molecular mechanism of PGRN in osteoarthritis IHH ATG12 RUNX2 BMP2 VCAM1 COMP XBP1 DKFZp686F0183 SIRT1 SOX9 PMC11839412__F3 Crucial miRNAs impacting CD133 and cell cycle regulation (By Figdraw DUSP5 RAB27A CCND1 CDK4 PMC11839412__F4 Other pathways involved in the regulation of CD133 and the cell cycle (By Figdraw BMI1 DUOXA1 HDAC1 STAT3 PMC1808970__F3 AIRE expression is controlled by the lymphotoxin pathway RELA RELB AIRE PMC12021630__F6 Molecular mechanism of PGRN in osteoporosis HEL-S-62p CSF1R CTSK RUNX2 NFATC1 ATF4 OSCAR ACP5 OSM PMC6482288__F3 Schematics presenting mechanisms of actions of approved and selected experimental cytokine and cytokine receptor agonists and antagonists IL1R2 IL1R1 TNF PMC12021630__F4 Molecular mechanism of PGRN in intervertebral disc degeneration RUNX2 AXIN2 IL1B PMC12021630__F8 Molecular mechanism of PGRN in DOP ACAN COL2A1 NOS2 MTOR IL1B PMC4613246__F2 AKT-independent PI3K signaling in cancer BTK PTEN PMC4613246__F1 PI3K/AKT signaling pathway TSC2 BAD PTEN PMC2883337__F1 Chromaffin cell genes involved in catecholamine biosynthesis, storage, secretion and degradation TH SPR SCG2 PTS CHGB PNMT DDC NPY MAOA VAMP1 PMC6139289__F3 A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780 ATF4 EGFR NRAS SOS1 PMC8700603__F3 Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer RIT1 MXD1 ALK SMAD2 GSK3B MYC SMAD4 FGFR4 DKK1 FGFR2 NF1 FGFR1 MXD4 MNT ACVR2B TLE4 MAPK1 ROS1 NTRK2 SFRP4 ERBB3 APC HRAS MLX SFRP5 DKK4 RHEB TSC2 RICTOR RET TSC1 MAX AXIN1 STK11 MGA TLE2 MLXIP TLE3 IGF1R BRAF EGFR PTEN DKK2 ERBB4 PTPN11 SFRP1 AXIN2 TCF7L1 ARAF KIT RNF43 PDGFRA DKK3 NTRK1 FGFR3 RAC1 MXD3 CBL MAP2K1 MYCL ERBB2 FLT3 SOS1 PMC3070484__F1 iNKT cell autoreactivity: what is “self” and how is it recognized? CD1D APC CD40 HEL-S-92n ICOS PMC8713748__F2 Systems biology analysis of human genomes points to key pathways conferring spina bifida risk ELF2 STAT1 PML CGAS SOCS3 STAT2 ROCK1 IRF9 BST2 TYK2 RHO JAK1 PMC4613246__F4 PI3K-independent AKT activation in cancer TBK1 PTK6 SRC PTEN PMC6517498__F2 Model of canonical inflammasome activation involving regulation of autophagy induced by Ehrlichia TLR9 MYD88 IL1B PMC6517498__F3 Model of regulation of inflammasome activation by type I IFNs in Ehrlichia infection TLR9 IFNAR2 MYD88 IFNAR1 IL1B PMC8931468__F6 Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/Beta-Catenin Pathway APC GSK3B PMC6104135__F3 Schematic summary of HIF-1 signaling in hypoxia and diabetes HIF1A HEL-S-133P NR1C1 PMC2684527__F2 Stochasticity in Protein Levels Drives Colinearity of Gene Order in Metabolic Operons of Escherichia coli MT3 MT4 MT1M PMC8419281__F2 An Update on Targeted Treatment of IgA Nephropathy: An Autoimmune Perspective HEL-S-62p C7 C6 MASP2 C1S PMC8319688__F4 Combining Genome-Wide Gene Expression Analysis (RNA-seq) and a Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compounds Against Candida albicans HEL-S-49 PGM2 PCK1 GLG1 GPD2 CYS1 ADH5 HEL-S-4 PMC4960866__F1 Overview on the role of apolipoprotein E (APOE) in the three main pathways of plasma lipoprotein metabolism ALPL LPL LDLR APOE PMC9520939__F4 Meta-transcriptomic comparison of two sponge holobionts feeding on coral- and macroalgal-dissolved organic matter TIGAR NONO WASF2 WDR26 PDIA4 TRAF3 TRAF6 IRAK4 MTA3 IQUB FAT4 NOP53 NLK CASP3 HSDL2 PMC3931971__F1 Simplified schematic of common mutations in the Hedgehog signaling pathway leading to basal cell carcinoma from pathway activation (a), and therapeutic targets of this pathway (b) PTCH1 SHH SMO PMC6664527__F2 The canonical Wnt signaling pathway APC GSK3B PMC6021456__F7 Interaction of LBR, Rab5, Nup205, and NXF1 in the PI3K/mTOR/AKT signaling pathway TSC2 EEF2K TSC1 IGF1R LBR PTEN EIF4E RPS6 EIF4B IRS1 RHEB PMC5429720__F6 DEGs related to fatty acid degradation and PPARA signaling pathway between APFL and AP TH ESD PPARG PMC9017276__F8 mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NFKB Signaling After Ischemic Stroke CGAS IRF3 ARG1 PMC6286780__F1 Zinc and zinc transporters are involved in FcERΙ-mediated mast cell activation FYN GAB2 ARHA PMC6092260__F2 MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development GRB14 MAP2 FOS MYC RHO CRK IRS1 GRB7 CRKL FRS2 GAB2 GRB2 BCL2 SHB FRS3 GRB10 CDC42 BAX PMC12221917__F2 Signaling pathway induced by TNFR2 LTA TRAF3 RELB TRAF2 PMC12007507__F2 Factors affecting DC maturation and function in NSCLC TLR4 CCL19 MYD88 NOD2 STAT3 PMC1502396__F1 The interaction between the AR and the ErbB/MAPK pathway BAD ERBB2 ERBB3 GSK3B MDM2 GRB2 SHE JUN PMC6583763__F1 N-linked glycosylation in the ER STT3A EDEM2 STT3B EDEM3 RPN1 PMC2517702__F3 Signal transduction in the CD95 pathway CASP3 FADD PMC11584862__F6 Two-step model describes the transition from naïve to primed epiblast and subsequent differentiation WNT3 SOX2 SMAD2 SMAD4 DNMT3B FOXH1 PMC7565380__F3 Most important ncRNAs that regulate ER and HER2 receptors, drug efflux, apoptosis, DDR, cell cycle arrest, EMT, and CSCs features in BC drug resistance BAD IGF1R RPA1 EGFR CD44 CDK12 PTEN MTOR BRCA1 CCNE1 ZNF17 TINCR ERBB2 ZEB2 CCND1 CDK3 BNIP3 PMC6568242__F2 Transcriptional Regulation of Proteasome Subunit Genes DDI2 DDI1 NRF1 YAP1 PMC9699340__F3 Constitutively Active Androgen Receptor in Hepatocellular Carcinoma TSC2 GSK3B FKBP5 PHLPP1 PMC6410766__F8 Signal transduction pathways that mediate migration induced by OA in breast cancer cells EGF EGFR SRC HBEGF PMC9279298__F1 Plasmacytoid dendritic cells during COVID-19: Ally or adversary? PDC TLR7 IRF7 IRF3 IRAK4 IL6 CD80 MYD88 ACE2 MAVS TMPRSS2 PMC3631463__F8 Combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation TLR4 FBXO3 TRAF6 MYD88 TLR1 TRAF2 PMC4834358__F1 Molecular pathways and targets of the epithelial–mesenchymal transition TWIST2 TWIST1 HEL-S-28 ZEB2 PTCH1 GSK3B TRAF6 SMO CDH2 HIF1A PMC4834358__F2 Hexosamine biosynthetic pathway (HBP) and glycosylated EMT targets SNAI1 SMO CDH2 PMC5604128__F3 Extracellular matrix-receptor interaction signaling pathway CD47 CD44 VWF CHAD PMC7343448__F10 Mechanism of Sirt1 associated Adriamycin-resistance in DLBCL cells ND6 ND1 TFAM SIRT1 PMC3895947__F4 Wide variety of glycoconjugates such as heparin sulfate proteoglycan (HSPG), chondrotin sulfate proteoglycan (CSPG), N-glycosylated cystatin C, and galectins-1 are involved in signaling pathways inducing proliferation and self-renewal of NSCs LIF GRB2 STAT3 PMC12130087__F1 Canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC6167374__F4 Prominent changes upon ageing in the central carbon metabolism CS HADHB CRAT RHO PFKM PYGB EN2 MDH2 GOT2 PC FH MSC PDHA1 ACO2 GPD2 OGDH SUCLG2 PDHX PFKP DLAT PGAM1 SDHA SDHB SLC25A20 ENO1 DLD IDH3B PHGDH HEL60 HEL-S-162eP HEL-S-68p HEL-S-49 CPT1A ENO2 SUCLG1 SUCLA2 ACLY ECHS1 SLC25A1 PYGL AGL PMC11876573__F6 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice following acoustic overexposure (AO) ANGPT2 DUSP10 RASGRP3 MAP4K3 MAPK10 EFNA4 TNFRSF1A TNF CACNA2D1 MAP2K6 IL1B PMC5900450__F2 Arachidonic acid (AA) pathway of inflammation mediators CDA COX2 LTA COX1 PMC11876573__F3 Association network of differentially expressed genes (DEGs) in the tumor necrosis factor signaling pathway in the organ of Corti in wild-type mice following acoustic overexposure (AO) CXCL1 SOCS3 FOS LIF PTGS2 CXCL10 RIPK3 CXCL2 MAP2K6 CEBPB MMP14 ATF4 RELA TNFRSF1A JUNB MAPK11 CSF1 JUN IL1B SELE IL18R1 PMC11876573__F5 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice before acoustic overexposure (AO) MAP3K7IP1 ANGEL2 EN1 JUN PMC3707916__F5 Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice CASP3 HMGB1 MAP2 CAMK4 DPYSL3 APP BCL2 CYFIP2 GAP43 NCAM1 TNF BAX PMC11671260__F2 Multiple drug treatments that interfere with the gut microbiota PYY IRAK4 MYD88 PMC7004849__F2 Cells within the skeletal niche utilize long chain free fatty acids (LCFA) for energy generation via two complimentary cellular catabolic processes of the carnitine shuttle and Beta-oxidation PCSK9 LDLR CPT2 HMGCR PMC7723893__F1 TNFR1 activation pathway RIPK1 CAP1 TRADD CYLD RIPK3 TRAF2 MLKL PMC5700458__F1 The UPR mediators have versatile roles in different cell types either in the presence of balanced or unresolved ER stress XBP1 STAT3 PMC5707529__F2 Schematic representation of the HIV-1 life cycle TRIM50 SLFN11 BST2 SERINC3 HMX2 PMC7723893__F2 TNFR2 activation pathway TRAF1 RELA TRAF3 TAB3 PMC9926998__F8 Ozonated Water Inhibits Hepatocellular Carcinoma Invasion and Metastasis by Regulating the HMGB1/NFKB/STAT3 Signaling Pathway HMGB1 MMP2 MMP9 PMC9669482__F4 Ferroptosis and its role in skeletal muscle diseases GPX4 SLC7A11 SLC3A2 PMC8039952__F4 Approaches to turn a “cold tumor” into a “hot tumor” CXCR4 DCT CD80 PMC8570409__F5 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn NLRP3 CGAS TRPV4 ACE2 ADAM17 PMC9603380__F12 Binding of Gamma-Glutamyl Transferase to TLR4 Signalling Allows Tissue Factor Activation in Monocytes TLR4 IRAK1 TRAF6 IRAK4 MYD88 TF TIRAP PMC8138266__F5 Inhibition of the Wnt/Beta-catenin signaling pathway reduces autophagy levels in complement treated podocytes GSK3B LRP5 LRP6 PMC5810418__F7 Small Wnt Pathway Solutions to nuclear Beta-catenin, denoted by a compartment marked ‘n’ for nucleus WNT3A APC AXIN1 LRP6 FZD5 PMC8419495__F4 Gene Expression Analysis Reveals Key Genes and Signalings Associated with the Prognosis of Prostate Cancer P2RX2 CCNA2 TTK GNA14 PTGER3 DRD2 TACR2 ADCY3 SSTR2 AURKA CNR1 CDC45 PLCB1 GNA11 EDNRA EDNRB RRM2 CCNB1 TBXA2R NPFFR2 ADCY5 PMC5810418__F8 Large Wnt Pathway solutions TLE4 APC LRP6 TLE2 TCF4 PMC8570409__F3 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn TH IL18 TLR7 TLR4 IRF7 IRF9 APC RIGI IRF3 MYD88 IL1B TLR3 PMC5810418__F6 Small Wnt Pathway Solutions to ubiquitinated Beta-catenin, denoted by a post-translational modification with a ‘U’ APC SKP1 AXIN2 PMC6321468__F2 The non-polyphenolic compounds’ major mechanisms of action on CRC cells CDC2 BAX PMC11841418__F1 3D printed magnesium silicate/Beta-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis RUNX2 GSK3B PMC10377024__F2 Landscape of Genetic Mutations in Appendiceal Cancers EGF HGF BRAF EGFR SMAD2 TGFBR1 GSK3B MYC TGFBR2 SMAD4 PLCG2 PTEN RHO NOTCH3 ATM NOTCH1 NOTCH4 APC LRP5 LRP6 HRAS GNA11 CDKN1A GRB2 GNAS FLT3 ATR TGFA PMC10377024__F3 Landscape of Genetic Mutations in Appendiceal Cancers EGF KIT HGF BRAF EGFR NRAS MYC PLCG2 RHO HRAS GNA11 ERBB2 GRB2 FLT3 TGFA PMC10377024__F4 Landscape of Genetic Mutations in Appendiceal Cancers EGF HGF EGFR FLT3 TGFA PMC10377024__F5 Landscape of Genetic Mutations in Appendiceal Cancers CDKN1A ATM TGFBR1 TGFBR2 ATR PMC10377024__F6 Landscape of Genetic Mutations in Appendiceal Cancers EGF HGF ERBB2 EGFR PIK3CA PTEN FLT3 PMC10377024__F7 Landscape of Genetic Mutations in Appendiceal Cancers GNA11 NOTCH4 APC GSK3B MYC AXIN1 LRP5 NOTCH1 LRP6 ARHA GNAS NOTCH3 PMC10377024__F8 Landscape of Genetic Mutations in Appendiceal Cancers SMAD2 TGFBR1 TGFBR2 SMAD4 PMC4232733__F1 The IGF1R/mTOR signaling pathway resulting in growth and survival of the cell IGF1R IGF1 IGF2 PTEN MTOR PMC6321468__F1 The polyphenols’ major mechanisms of action on colorectal cancer (CRC) cells COX2 CDK2 PMC10957658__F3 COX-2-PGE2 signalling pathway in RCC SRC RAP1GAP STAT3 PMC11531455__F7 A5-nAChR and SOX2 signaling cascade is involved in lung cancer progression and immune escape SOX2 STAT3 PMC10957658__F4 Membrane receptor mechanism of EET in RCC CYP2J2 CYP2C9 EGFR CCND1 BCL2 HBEGF FOXO1 BAX PMC4505437__F8 CFZ inhibition of PTH-induced osteoclastogenesis TRAF6 PTH PMC4396380__F1 Reduced Tyk2 gene expression in Beta-cells due to natural mutation determines susceptibility to virus-induced diabetes STAT2 ATF2 IRF3 IFNAR2 IFNAR1 TLR3 MX1 STAT1 TLR8 TLR7 TYK2 JAK1 IRF-1 IRF2 PMC8590789__F6 Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/Beta-catenin pathway in hepatocellular carcinoma SOX2 EPCAM CCND1 WIF1 PMC10957658__F1 AA metabolism LTA COX1 COCH PMC8765545__F7 Exploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up COX2 BAD CASP9 CDC42 PMC8193087__F1 Selenium Transport Mechanism via Selenoprotein P—Its Physiological Role and Related Diseases SELENOP PSTK ARR3 PMC4924662__F6 FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3B/Beta- catenin signaling cascade via FGFR4 activation GSK3B FGF19 FGFR4 PMC7847648__F4 PPI network construction revealed the most significant modules, and signaling pathway enrichment analyses were conducted for the module genes FOXM1 BIRC5 CDKN3 CCNB1 TYMS CENPE HJURP CENPN CDC45 PTTG1 TRIP13 PMC9676466__F6 Whole genome analysis for plant growth promotion profiling of Pantoea agglomerans CPHN2, a non-rhizobial nodule endophyte TH ADA EMB PMC6538920__F1 Wnt signaling pathways APC GSK3B LRP5 LRP6 JUN CP PMC6538920__F2 Wnt signaling deregulation in the aging brain and in AD GSK3B LRP5 LRP6 DKK1 PMC7713372__F4 Functional profile of main vitamin D target genes THBD FBP1 LAMB3 CYP24A1 HBEGF S100A9 HLA-DRB1 AQP9 STAB1 G0S2 CYP27A1 CCL24 THBS1 SEMA6B OSM MPEG1 RASAL1 TGFBI PMC166813__F1 The GA biosynthetic pathway in pea SLN PMC7276919__F1 DNA Sensing in the Innate Immune Response TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 DKFZp686F0183 IRF-1 PMC7276919__F2 cGAS/STING pathway, a major cytosolic dsDNA sensing pathway mediating type I IFN signalingcGAS is localized close to the plasma membrane TBK1 CGAS IRF3 DKFZp686F0183 PMC7276919__F4 RNA helicases, the proteins sensing dsDNA and the cross talk between dsDNA and dsRNA sensingDHX9 binds to CpG-B DNA through its DUF1605 domain and leads to NFKB pathway activation and proinflammatory cytokine release TBK1 CGAS IRF7 TRAF6 DHX36 DDX41 IRF3 MAVS PMC4269174__F4 Complementary metabolic pathways between the brown planthopper and its yeast-like symbiont NHS PROC TEP1 PMC8538427__F11 Polar Oxy-metabolome Reveals the 4-Hydroxymandelate CoQ10 Synthesis Pathway HPDL COQ3 LDHD HPD COQ2 COQ6 COQ5 D2HGDH COQ7 PMC5142153__F1 Summary of extrinsic, intrinsic and membrane stress apoptotic pathways ATM MDM2 FADD BAX PMC7605660__F7 The underlying mechanisms of zeaxanthin’s effects on signaling pathways and the induction of apoptosis in human gastric cancer cells BAD CDK2 CCNB1 PARP1 CDC2 ROS1 STAT3 PMC3984876__F1 Cilia in the nervous system: linking cilia function and neurodevelopmental disorders LRP5 SHH LRP6 SMO PMC6462325__F4 The effects of Cordyceps militaris on the levels of the main molecules in the TLR4/NFKB pathway in CKD patients COX2 TLR4 IL1B PMC9139434__F1 Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce A “Hot” Tumor Microenvironment That Is Responsive to Immunotherapy TBK1 CGAS IRF3 PMC6704133__F6 Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma EGFR SRC RHO ITGB1 PMC8197226__F1 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis HEL70 DUSP10 FOS JUN PMC8197226__F3 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis EGF KIF1A WDR62 PMC5459509__F12 Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations GPC4 APC RHO PMC8369417__F6 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases BTK NFATC1 BASH LYN TEC MYD88 CD19 PMC4474402__F5 Dysregulation of astrocyte extracellular signaling in Costello syndrome ELK3 SNAI2 PNN NFIA HES1 PMC8369417__F5 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases BTK TLR7 TLR9 NFATC1 LYN TNF PMC7912299__F4 Pathways to the generation of cytosolic and mitochondrial citrate and its utilization FH ACO2 CIC ACLY SLC13A5 HMGCR GLS PMC8369417__F3 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases TLR4 NFATC1 TRAF6 IRF3 RAC1 MYD88 TLR1 PMC8369417__F1 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases CTSK NFATC1 OSCAR DCSTAMP TRAF6 PLCG2 RAC1 BTK VAV3 BASH SYK CDC42 EEIG1 PMC7912299__F8 Mitochondrial and cytosolic pathways leading to D2-L2 hydroxyglutaric acid (D-L-2HG) accumulation (see text for explanation) CIC D2HGDH PHGDH HEL-S-32 L2HGDH MDH2 PMC6405411__F6 Signaling pathways activated by the LH surge in ovulatory follicles EREG ERBB2 AREG ERBB3 NRG1 LHCGR PMC7846784__F1 Perspectives on skeletal muscle stem cells TSC2 HMGB1 TSC1 HGF AHR CXCR4 PTPN11 CXCL12 MTOR KLF7 PMC4474305__F9 The differential subversion of type I IFN and mitochondrial apoptotic pathway by LCMV TBK1 TRAF3 IRF3 MAVS BAX PMC8627558__F2 Dynamic and cell-specific transport networks for intracellular copper ions ATP7B ATP7A ATOX1 PMC4992261__F4 5 nM PhIP activates STAT3-mediated transcriptional regulation ALPL LEP EGR1 ANGPTL2 POSTN TXNIP SAA1 SGK1 STAT3 PMC6405411__F8 PGE2 synthesis, receptors, transport, and metabolism in granulosa cells PTGER2 HPGD PTGER1 PTGS2 PTGES PTGER4 PTGER3 LHCGR PMC12153588__F5 Microtubule dynamics regulated by interconnected pathways coordinating polymerization and depolymerization PLK1 CCNB1 CDK5 ARHA PMC12153588__F6 PI3K-Akt pathway’s role in coordinating cytoskeletal dynamics during axon guidance by regulating microtubules, intermediate filaments, and actin networks LIMK2 LIMK1 MAP4 GSK3B ARHA PTEN RHEB CRKL PMC4847623__F1 Sphingolipid biosynthetic pathway GHB3 ORM2 MIP ORM1 PMC12153588__F4 Microfilament signaling pathway LIMK2 LIMK1 ARHA CDC42 PMC4058013__F3 KLK5 protease suppresses breast cancer by repressing the mevalonate pathway PCSK9 DHCR7 LDLR RHO HMGCR HSD3B7 PMC8423867__F3 N-terminal acetylation and lysine acetylation SIRT2 TAF1 ESCO1 MHC2TA MCM3AP CDY1B HDAC3 HDAC10 HDAC8 ATF2 HDAC7 ELP3 HDAC5 HDAC1 SIRT3 SIRT7 SIRT4 SIRT5 SIRT6 HDAC2 ESCO2 HAT1 SIRT1 PMC8423867__F4 The protein acetylation in regulation of cancer-associated events STAT2 ATM PCK1 IRF9 PTEN FOXO1 SKP2 PMC9157426__F3 Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity ANGPTL4 PYY PMC8900014__F1 Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway STAT2 IRF9 IFNGR2 TYK2 IFNAR2 IFNAR1 IFNGR1 IFNLR1 PMC9420268__F1 Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response FGF23 FRS2 FGF6 GRB2 CDK4 MTOR CDK6 CCND2 PMC4773096__F1 Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways TSC1 GRB2 PTEN MTOR RHEB PMC2926987__F3 Reconstructed antioxidant regulation pathway of detoxifying proteins EPHX1 KEAP1 MAPK8 MAFF FOS GCLC NFE2L2 MAPK14 CREB1 POR CRYZ MAFK ATF4 HEL-S-44 MAPK1 JUN TF MAFG PMC5866353__F1 Compiled summary of signaling pathways activated by prostanoid receptor PGE2 receptor 2 (EP2) in osteocytes, neurodegenerative diseases, and colon cancer (see text for details) HGF EGFR SRC PMC12067647__F5 The cytokine-cytokine receptor interaction pathway in IIM patients with/without anti-MDA5+ autoantibodies LEP AMH CD7 LIF INHA TPO CXCL3 IL4 CXCL12 TSLP TNLG7C MPL PMC3628025__F7 Proposed model suggesting that TGFB increases COX-2 levels and PGE2 secretion in prostate cancer cells and both TGFB and PGE2 activate PI3K/AKT/mTOR signaling pathway EGF SMAD2 EGFR MTOR PMC6447799__F3 Leptin signaling pathways SOCS3 MTOR STAT3 PMC4870076__F6 Potential mechanism underlying Qinggan Huoxue Recipe-mediated inhibition of epithelial-to-mesenchymal transition in alcoholic liver fibrosis rats SMAD2 SMAD4 PMC3636761__F1 PI3K signaling pathway and the downstream targets of Akt TSC2 BAD TSC1 GSK3B CCND1 PTEN PMC6270750__F1 Astragaloside biosynthetic pathway MVD IPP MVP PMC6175639__F8 Schematic Illustrating Potential Pathways for Glucose Utilization and Energy Production by Tendon Cells EGF SMAD2 HIF1A HEL-S-133P PMC5831777__F3 Hh signaling within the developing TMJ PTCH2 IHH RUNX2 PTCH1 GLI3 SMO COL2A1 COL10A1 SOX9 PMC10152377__F1 Somatic Variants Activating Ras/Raf/Mitogen-Activated Protein Kinase (MAPK) Pathway Genes in Mesial Temporal Lobe Epilepsy NF1 GRB2 PMC10346897__F4 Mechanism by which PUFAs suppress cholesterol synthesis via inhibition of the signaling pathway of sterol regulatory element-binding protein-1 (SREBP-1) [74] INSIG1 ABCG8 ABCG5 ABCG1 PMC5958547__F1 New Opportunities and Challenges to Defeat Cancer Stem Cells CXCR1 SMO STAT3 PMC10845654__F8 Working model PAQR7 BAX PMC4407014__F4 An incomplete engagement of the TCR pathway differentiates BT-061 from other anti-CD4 mAbs UNK PMC2710138__F8 Feedback inhibition of the phosphatidylinositol 3—kinase (PI3K) pathway TSC2 RICTOR PTEN MTOR RHEB MLST8 PMC9929207__F4 MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis MAPKAPK2 ELAVL1 ZFP36 PMC2710138__F2 Phosphatidylinositol 3—kinase (PI3K) signaling pathway TSC2 BAD TSC1 MDM2 PTEN RAC1 RHEB CDC42 PMC4900191__F2 Regenerative Medicine: Charting a New Course in Wound Healing PROP1 CYLD MYC MAP3K7IP1 PMC6347283__F1 Representation of signaling pathways upstream of MTORC1 TSC2 TSC1 MAPK13 MAPK3 TBC1D7 MAPK1 PTEN RRAGA IRS1 DDIT4 RHEB PMC6347283__F2 Effectors downstream of MTORC1 EEF2K ATF2 EEF2 MYC EIF4E HIF1A MTHFD2 PHGDH PC SIRT4 PPARGC1A ATF4 ASNS BCL2 YY1 MCL1 CAD RPS6 PPARG EIF4B GLUD1 STAT3 GLS PMC8894463__F8 Schematic illustrating the mechanism by which TRIM45 regulates cerebral I/R injury by activating NFKB signaling in microglia TRIM45 MAP3K7IP1 PMC7509400__F2 Immune functions of GD T cells in cancers MICB MICA IL1B PMC6068089__F9 Schematic depicting neuroprotective roles of BRCA1 towards I/R injury GPX4 GCLC BRCA1 PMC3222593__F2 Pathway Studio® (Ariadne Genomics) was used to identify known relationships among human homologues of the genes identified as differentially regulated by ANOVA TH HEL-S-302 FOS GPT MYC INS HDAC1 NR1C1 PS1TP5BP1 HEL-S-162eP PMC8072347__F1 OSCAR Signaling in Osteoclastogenesis and Bone Disease BTK NFATC1 BASH TEC SRC TRAF6 PMC4594952__F3 Concise review on the current understanding of pancreatic cancer stem cells SOX2 EPCAM FOXM1 APC GLI3 GSK3B CD44 SHH DKK1 HES1 PMC6788756__F2 Functions of the calcineurin signaling pathway in S MID1 YAP1 HEL-S-84 HEL-S-11 GPX2 RCN2 SIM1 VPS36 HES1 SIM2 PMC11523277__F1 Effect of ubiquitination imbalance on osteosarcoma cells and its clinical application TRIM46 ARIH1 TRIM21 USP9X MDM2 TRAIP RNF180 USP1 PMC11523277__F2 Ubiquitin-mediated regulation of key signaling pathways in tumor cells ZNRF3 USP4 RNF7 USP19 RNF43 USP2 TRIM21 USP33 MLF2 UBE2T MKRN1 FBXW7 TRIM26 OVOL2 CUL4B USP16 TRIM66 MDM2 SPOP TRIM37 ITCH PMC8471964__F6 Idebenone Decreases AB Pathology by Modulating RAGE/Caspase-3 Signaling and the AB Degradation Enzyme NEP in a Mouse Model of AD BACE1 APP ADAM17 PMC11523277__F3 Dysregulated ubiquitination pathway drives osteosarcoma malignancy KEAP1 RUNX2 TRIM46 ARIH1 TRIM21 MYCBP A1BG ALKBH5 MTOR CDK7 MEF2D NLRP3 POLE2 USP9X MDM2 CHPF USP22 KLF6 RNF180 CD44 L3MBTL2 ARHA TRAIP CBX4 SIRT1 PCNA SKP2 USP1 HEL-S-43 PMC3621012__F2 Regulation of miRNA biogenesis and turnover in the immune system MYB IRAK1 MYC TRAF6 PMC5072418__F1 Proposed Pd0/PdII catalytic cycle for aryl fluorination PDF ARX PMC5918594__F4 Proinflammatory challenge and anti‐inflammatory drugs on expression of genes related to tryptophan and kynurenine metabolism SLC7A5 IDO1 HAAO TPH1 SLC16A10 KYNU GOT2 KMO MAOA AFMID SLC3A2 PMC5371895__F1 Schematic metabolic model showing important pathways after proliferation of Streptococcus suis serotype 2 in porcine blood (A) and cerebrospinal fluid (CSF) (B) PTS GAL CIT PMC2796203__F1 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer EGF TGFBR1 GSK3B RHO STRAP TGFBR3 TF CDC42 PMC2796203__F2 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer SMAD2 TGFBR1 SMAD4 PMC11523277__F4 Potential of ubiquitination modulation in osteosarcoma treatment ZNRF3 SOX2 TRIM46 RAB22A TRIM28 DDRGK1 RNF4 RAD18 FBXW7 USP1 PMC3287202__F6 Overview of pre-miRNA processing AGO2 DICER1 DROSHA LIN28A PMC11833784__F5 Schematic representations of energy metabolites and enzymes involved in glycolysis, TCA cycle, ETC and AMPK pathway in ileum of layer pullets CS NRF1 TFAM PMC6916690__F2 Signaling pathways and cross talk, regulated by E-cadherin EGFR ARHA RAC1 TNF MTOR PMC12035655__F10 Novel Wnt/Beta-catenin signaling gene signature for progression and metastasis of gastric cancer TCF3 AEBP1 FZD2 HEL113 CPZ PMC6505469__F10 Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro ATF4 TRIB3 PMC2671916__F6 Novel functional modules with dynamic gene expression changes potentially linked to prion pathophysiology: (A) androgen metabolism, (B) iron metabolism, (C) arachidonate/phospholipid metabolism DBI LTA AMPD3 LTB HFE HSD3B7 PMC3618522__F1 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment RARA RARB CCND1 FABP5 PMC3913495__F1 IL-6 exerts its pleiotropic activity by activation of gp130 through its binding to transmembrane or soluble IL-6 receptor CRP GRB2 STAT3 PMC3618522__F2 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment RARA RARB PARP1 PMC6963578__F2 Schematic diagram of interactions between arenavirus proteins and host innate immune machinery TBK1 EIF2A IRF3 PMC5742799__F2 Hypothetical model for the proposed anti-inflammatory role of MUC1 in response to P MUC1 TLR5 IRAK1 EGFR TRAF6 IRAK4 MYD88 SP1 TNF TGFA PMC5759160__F3 Schematics of the Wnt/Beta-catenin signalling pathway APC GSK3B LRP5 CCND1 LRP6 PMC8134663__F2 Unraveling the Role of the Apical Papilla During Dental Root Maturation HHIP SOX2 RUNX2 APC NOTUM LRP5 LRP6 DSPP FGFR2 FGFR1 WNT3A WNT4 SHH PMC7697917__F8 BDNF pathway AHR FOS RELA HDAC2 BDNF NTRK2 STAT3 PMC5849167__F5 Ang-2 up-regulating EMT and facilitating lung cancer metastasis EPO IGF2 VHL ENO1 HEL113 NOS2 MTOR TGFA ADM HEL-S-68p HEL-S-162eP PMC8132202__F4 Risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models VCAN hCG_2044782 HIF3A SYTL5 PCSK5 INPP4B IGFBP5 NRK SYTL2 PDGFD VAV3 NDNF IGFBP4 GHR PID1 MFAP4 MSMB FNDC1 INHBA FIGN PMC5504240__F1 Circadian metabolites have pleiotropic mechanisms by which to maintain cellular rhythmicity ME2 SIRT6 VIPR2 MTOR GPR176 NPAS2 SIRT1 PER2 SIRT3 PMC3133259__F1 The CoA biosynthetic pathway PPCS PPCDC PMC3248184__F1 YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention GSK3B SRC PMC5352107__F4 Triple-negative breast cancer: is there a treatment on the horizon? FACL4 EGFR MTOR PMC8479803__F1 Vascular smooth muscle cells in atherosclerosis: time for a re-assessment SCAI RUNX2 ACTA2 MYOCD KLF4 TCF21 SOX9 CD68 TAGLN CD36 PMC7486896__F8 Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/Beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma MMP7 MMP2 SP1 PMC8357478__F9 Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving AB CDC2 PDK4 TF PMC5466513__F1 Autophagy in UV damage response TSC2 ULK1 TSC1 ATG12 ATG3 PTEN UVRAG SESN2 ATG10 DKFZp686F0183 RHEB PMC8307504__F6 Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation TBK1 CGAS IRF3 PMC5571543__F8 Proposed mechanism of ESA‐mediated downregulation of Foxp3 in regulatory T cells SMAD2 SMAD4 FOXP3 PMC4263025__F1 RAF fusion genes in prostate and gastric cancer and melanoma BRAF RAF1 AGTRAP ESRP1 PMC8430084__F2 Neutrophil extracellular traps (NETs): the role of inflammation and coagulation in COVID-19 TFPI PLG FDPS ADAMTS13 VWF TF PMC6592994__GA Biological role of MALAT1 in cyclin D1, miR-363-3p and Mcl1 gene regulations APC CCND1 MCL1 PMC3313594__F3 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery SMAD2 SMAD1 TF DKFZp781O1323 PMC9138253__F3 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase APC GSK3B LRP5 SRC LRP6 ARHA ROR2 HEL113 ROR1 CDC42 TRIO PMC3313594__F5 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery SMAD4 SMAD1 DKFZp781O1323 PMC1817809__F1 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues AgRP MTOR HEL-S-5 PMC4609654__F1 The Wnt signaling pathway with selected inhibitors RNF43 APC WNT1 GSK3B WNT10B PMC9138253__F6 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase ROCK2 ROCK1 GSK3B LRP5 SRC LRP6 ARHA PMC1817809__F2 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance CNTF MTOR HEL-S-5 PMC3322992__F8 Pathways required for the role of CDCP1 in EGF/EGFR-induced cell morphological changes and increased cell migration EGF EGFR CDCP1 PMC8926078__F1 Non-Coding RNAs in Autophagy During Carcinogenesis HMGB1 ULK1 ATG12 ATG3 EGFR AMBRA1 PTEN ATG101 ULK2 ATG10 DKFZp686F0183 TSC2 TSC1 UVRAG STX17 BNIP3 ATG14 PMC6828502__F1 Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol DDC PMC2735908__F8 Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway WNK1 PDK2 DCT OSR1 WNK4 SGK1 PMC12230486__F4 Metabolic Adaptations and Therapies in Cardiac Hypoxia TIGAR SHD SIRT4 PAX5 F2 FH MYC HEL-S-51e HEL-S-133P TXN HK2 GLS PMC6499784__F4 Schematic representation of a proposed model of the TBS pathway interaction with PET FECH PC CYB PMC8249349__F1 Metabolic alterations in pancreatic cancers ME1 GOT2 RPIA CIT RPE HEL-S-32 HK2 MAL GLS PMC8249349__F2 Pancreatic cancers rely on autophagy and lysosomal scavenging ULK1 ATG16L1 ATG12 ATG3 ATG101 STX17 MTOR ATG14 DKFZp686F0183 PMC9068506__F3 Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response TLR8 TLR7 STAT2 IRF9 MYD88 ACE2 MAVS PMC6854743__F8 Signaling pathway of the Akt + diuron-induced glioma UHRF1 PCNA PMC7266824__F2 Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects IKBKG PLCG2 MTOR IL6R IKBKB NFKBIA BTK BCL10 BCR RELA LYN SYK JAK1 STAT3 PMC12230486__F1 Under Hypoxic Conditions, The Energy Metabolism of Cardiomyocytes ChangesMany of the discussed pathways show protection against ischemia-reperfusion injury (IRI) (green arrows) or are protective if blocked (red arrows) TIGAR SHD IKZF1 SIRT4 PAX5 F2 FH MYC HEL-S-51e HEL-S-133P TXN GLS PMC11352684__F4 TRIM proteins in the cellular signaling pathway of MAFLD GPX4 TNIP3 TRIM16 TRIM21 TRIM8 HIF1A TRIM26 TRIM59 RHBDF1 TRIM65 SNX8 CEBPD TRIM67 TRIM38 TRIM24 SIRT1 FASN TAB3 PMC12230486__F2 Metabolic Adaptations and Therapies in Cardiac Hypoxia PDK4 HIF1A NR1C1 CD36 PMC5722516__F7 Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis CIP2A MTOR PMC12230486__F3 Metabolic Adaptations and Therapies in Cardiac Hypoxia TIMD4 VEGFC VEGFA MERTK CD36 PMC9654020__F1 Looking into Endoplasmic Reticulum Stress: The Key to Drug-Resistance of Multiple Myeloma? ATF4 MCU MTOR TRAF2 XBP1 CAMKK2 PMC10572085__F2 Signaling pathways of the CD44 intracellular domain (CD44-ICD) under hypoxia SOX2 ECD RUNX2 CD44 CCND1 PFKFB4 PMC10572085__F3 Signaling pathway activated by HA-CD44 interaction ERBB2 EGFR CD44 RHO RAC1 CDC42 PMC6130388__F6 Schematic of proposed model IL16 IL1B PMC4850468__F1 Molecular Mechanisms of EndoMT TIMP1 SMAD2 PTCH1 SHH SMAD4 NOTCH1 NOX4 SMO HIF1A COMP PMC10572085__F5 HA-CD44 binding-activated signaling pathways SOX2 CD44 BCL2 PMC8485759__F4 Purine synthesis and its dependency on mitochondrial metabolism ADSL PAICS MTHFD1 HEL-S-70p PMC12211383__F1 Sources and metabolic functions of serine PSAT1 SHMT1 PSPH HEL-S-51e PHGDH PMC11815735__F9 Proposed mechanism elucidating the involvement of EBV in oral cancers encompasses the regulation of host cellular lncRNA LINC00944 STAT1 CXCL10 CXCL9 CD80 IRF-1 CCL3 PMC5630322__F7 Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma EGF MSC EGFR PMC7641864__F7 Metabolomics analysis of the mechanisms of hUCMSC treatment for POI OMP AIRE APOA2 PMC10388466__F7 Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NFKB activation via disrupting multiple-site ubiquitination of NEMO ANXA1 SHARPIN PI16 PMC7026421__F1 Rho-ROCK signaling mediates entotic cell death in tumor FH DAP RHO PMC7586277__F7 Pathway leading to phagocytosis of senescent AD-MSCs HEL-S-62p NLRP3 CD14 IL18 IL16 TLR4 TXNIP C3AR1 PMC6721448__F3 BRAF-mediated signaling in normal and cancer cells NF1 HGF BRAF EGFR CDK4 MTOR PMC3196116__F10 Proposed model shows the requirement of the IL-4RAlpha-Jak2-mediated signaling pathway for IL-13-induced M2 gene expression in human monocytes/macrophages STAT1 STAT3 CD36 PMC9381384__F1 Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B12 metabolism: A meta-analysis ABCD4 LMBRD1 MTR MMAA MMACHC MMADHC PMC7779201__F3 Hypothesis of Apatinib acquired drug‐ resistance mechanism caused by WRN point mutation MDM2 PTEN WRN ROS1 PMC8763889__F2 Carcinogenic mechanism of TFF3 BAD COX1 PGR EGFR GSK3B IL8RB RHO MTOR LINGO2 CXCR4 BCL2 CDH2 TFF3 ARAF STAT3 TERT BAX PMC5773092__F7 Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers BRAF SHH HRAS PMC9114637__F1 Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis TRPV4 PIEZO1 IL1R1 ACAN PMC3099033__F9 Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling TSC2 TSC1 RPS6 RHEB PMC8956597__F3 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD BRAF NCK2 EGFR PAK6 GSK3B MYC PAK4 MTOR CRKL NCK1 SRC CCND1 MAPK1 ARAF JUN ABL2 CAMK2D CAMK2G MAP2K2 RPS6KB1 PAK1 CDKN1A RPS6KB2 GRB2 SHC1 AKT3 PMC5499671__F3 TGFB regulation of T cells in multiple sclerosis SMAD2 SMAD4 TGFBI FOXP3 PMC8956597__F4 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD BRAF NCK2 EGFR PAK6 GSK3B MYC PAK4 MTOR STAT5B CRKL NCK1 SRC CCND1 MAPK1 ARAF JUN ABL2 CAMK2D CAMK2G MAP2K2 RPS6KB1 PAK1 CDKN1A RPS6KB2 GRB2 SOS1 SHC1 AKT3 PMC8956597__F5 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD BRAF NCK2 EGFR PAK6 MYC PAK4 MTOR CRKL NCK1 SRC CCND1 MAPK1 ARAF JUN ABL2 CAMK2D CAMK2G MAP2K2 RPS6KB1 PAK1 CDKN1A RPS6KB2 GRB2 SOS1 SHC1 AKT3 PMC6281578__F8 LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA GSK3B PIK3CA RXRA PMC2774878__F2 The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis EGF CXCR4 VHL CXCL12 PMC3195753__F3 Comparative analysis of plastid transcriptomes in cucumber RPS18 PC RPS19 RPL22 RPL36 RPS7 RPS11 CYB RPS15 RPS8 MATK CLPP PMC5988607__F3 Regulators of MST1 and MST2 LATS1 LPA LATS2 PMC7047199__F1 Radiation-induced effects on pathways related to mitochondria in cardiac cells GSTA4 KEAP1 PGAM5 NR1C1 BAX PMC8921539__F4 Hypoxia and chronic kidney disease EPOR EPO KEAP1 EGFR VHL PMC10867724__F4 Demonstration of the TNF signaling pathway and the target to be tested CASP3 TRADD CYLD TNF TRAF2 JUN FADD NOD2 MLKL SELE ITCH PMC4349561__F2 Pathway analyses of direct interactions among transcripts mediated by P4 in the ovary MYH9 CD59 PAK1 PGR SNX9 SPEN PGRMC1 TRAF4 PMC4349561__F3 Pathway analyses of A) tumor protein p53 (TP53) B) E2F transcription factor 1 (E2F1), and C) miRNA 124-1 FEN1 MYB MCM5 MYBL2 IFRD1 PKD1 TOP2A CDKN2A TRAF4 POLI PMC6198132__F3 Hypothetical scheme for the unfolded protein response-induced signaling cascade in MANF-deficient beta cells BCL10 ATF4 EIF2A TRIB3 CSA2 TRAF2 XBP1 RFWD2 PMC3444501__F4 Therapeutic Effects of Astragaloside IV on Myocardial Injuries: Multi-Target Identification and Network Analysis EGF KIT EGFR ALB MAPK14 ENG HPSE HEL-S-162eP HLA-A NF1 DAPK2 MAPK12 RAC3 F2 CRP BST1 CD40LG SELP NCF1 TGFA ACE2 MME STAT3 PMC9104445__F8 Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway MMP7 NGF MMP9 PMC4947819__F2 SOX2-mediated sensing of cytoplasmic DNA and the associated signaling pathway in neutrophils SOX2 ATF2 IL1B PMC8959092__F3 Repurposed drugs targets in ovarian cancer COX2 SOX2 MTOR PMC7894323__F6 Infigratinib and ribociclib in inducing differentiation and preventing dedifferentiation CDK2 FRS2 GRB2 CCND1 CDK4 CDC2 MTOR CDK6 SOX9 PMC11629812__F6 S‐Nitrosylation of NOTCH1 Regulates Mesenchymal Stem Cells Differentiation Into Hepatocyte‐Like Cells by Inhibiting Notch Signalling Pathway NOTCH1 HES1 PMC8523946__F3 MiR-873-5p: A Potential Molecular Marker for Cancer Diagnosis and Prognosis HOXA9 MMP9 APC GSK3B PTEN TNF MTOR MAP3K7IP1 CXCL16 JMJD8 TRAF5 PLEK2 GRB2 NDFIP1 TRAF2 TUSC3 PMC12112582__F4 Illustration shows the GPCR signaling pathway exploited by neuropeptides in insects to transmit signals regulating various physiological processes, including the mating behaviors NPS PROC PDF PMC8521155__F1 The Complement System by Neoplastic Disease of the Central Nervous System HEL-S-62p CD59 CD46 CD55 PMC4224453__F10 miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells PHLPP2 PTEN RAC1 CDC42 PMC7877185__F3 Competing endogenous RNAs (ceRNAs) and the signaling pathways involved in lung cancer cell invasion and migration EGF GSKIP RUNX2 ADAM15 MADD EGFR SMAD2 TGFBR1 MMP11 GSK3B TGFBR2 SMAD4 PTEN MTOR MMP7 MMP2 SLC12A5 MYEOV ZEB2 ZFHX4 EZH2 CDH2 TGFBR3 SMS MMP9 VEGFA FOXO1 HMGA2 BRD4 PMC7877185__F1 Competing endogenous RNAs (CeRNAs) and the signaling pathways involved in lung cancer cell proliferation EGF CCNA2 IGF2 MYC PTEN IRS1 E2F3 CDK6 RRM2 CYLD CDK2 E2F2 PCNA SKP2 PMC7404143__F5 Roles of NRP2 in SMC phenotypic switching ARHA NRP2 PMC3084021__F1 Conservation of the RB and Hippo signaling pathways in humans and fruit flies MCM3 CDK2 CDK4 LATS2 PMC6441712__F7 Effects of SIRT2/cMYC pathway in CCA cells.SIRT2 and cMYC reprogrammed the metabolism of CCA cells by up-regulating downstream p-PHDA1 and PHGDH/PSAT1/PSPH SIRT2 PDHA1 PSPH PHGDH PMC7404143__F3 Endothelial cell NRP2-mediated signalling pathways ANGPTL4 SMAD2 TGFBR1 VEGFA RRAS ARHA NRP2 PMC523224__F6 Metabolic pathway leading to generation and detoxification of MG MAOA HEL107 RPE PMC8293794__F1 New developments implicating IL-21 in autoimmune disease STAT1 IL21R IFNG STAT3 PMC8738868__F4 Emerging commonalities of circRNA-mediated signaling pathways APC GSK3B PMC8293794__F2 New developments implicating IL-21 in autoimmune disease STAT1 JAK3 JAK1 PMC6052012__F4 Metabolic construction of the putative pathway for AOM coupled to Fe(III) reduction in “M MTR CYB PMC4835044__F8 Schematic depicting the Arg-auxotrophic response BRAF GSK3B AXL ASS1 PMC9413556__F1 Targeting IRE1Alpha-JNK-c-Jun/AP-1-sEH Signaling Pathway Improves Myocardial and Coronary Endothelial Function Following Global Myocardial Ischemia/Reperfusion ATF4 EIF2A XBP1 PMC3591455__F5 Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells BTK BASH LYN GRB2 SYK CD19 PMC6865334__F8 Potential pathway for enhanced invasion upon mechanical stimulation PAK1 LIMK1 RAC1 PMC10991915__F4 Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation PDC CIT RPE MAL PMC5385655__F6 Schematic representation of the effect of S3I-201 in obesity-induced extensive mammary hyperplasia MMP2 STAT3 PMC8489683__F1 Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node NAMPT NRF1 FOXO3A VHL HIF1A TFAM FOXO1 PMC4673623__F1 Simplified diagram of one-carbon metabolism (1-CM) including the methionine cycle, the roles of one-carbon nutrients, and links to lipid metabolism HEL-S-61p PC PEMT PMC7140716__F1 Role of ARTS and Smac in induction of apoptosis TRADD TRAF2 FADD PMC7140716__F2 Models for Smac-mimetic (SM) and ARTS-mimetic (AM) mode of action RIPK1 TRADD TRAF3 RELB RIPK3 TRAF2 FADD PMC4922058__F4 Illustration of metabolic pathways reported to have altered gene and metabolite expression by integrated pathway analysis (MetaboAnalyst) ME1 CHKA AGPAT4 LPCAT2 ALDH2 HEL-S-281 PMC4354890__F1 Causes and Consequences of Replication Stress MCM3 MCM5 MCM6 MCM2 ATRIP MCM7 DDT ATR PCNA PMC2854673__F1 Minimally oxidized LDL induces TLR4-dependent lipoprotein uptake by macrophages CD14 TLR4 VAV1 SYK RHO CDC42 PMC8348875__F8 Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE) CCND1 CDK4 BAX PMC9675355__F5 Regulators of nucleotide excision repair (NER) in melanocytes EDNRB XPC MC1R XPA ATR PMC4676710__F1 A and B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) autoimmune response in WHI human prediagnostic TNBC samples, based on Ingenuity Pathway Analysis FOS POR PMC4676710__F3 And B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) response in C3(1)-T TNBC mouse model samples collected before palpable tumor compared with baseline, based on Ingenuity Pathway Analysis STXBP3 TRIM2 ESRRA NFYA HEL-S-43 PMC4694982__F9 By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis EPCAM FOS JUN PMC2670521__F9 New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis FHL1 PRKCE FHL3 NPC1L1 BCL2L1 SPHK2 SFTPB HEL-S-5 ASAH2 LCK LYN FHL2 SRC CTNND1 SNW1 RPS6KC1 PRPH2 SMPD1 SPHK1 NRAP SP1 TRAF2 PECAM1 SP3 PMC4698256__F1 Proposed cytotoxic mechanisms of NEDDylaton inhibition in human malignancies WEE1 MTOR CDT1 DEPTOR PMC4896925__F2 Localization of AKAPs in T cells PMC6875203__F3 Cross talk between induction of mitochondrial oxidative/nitrosative stress and autophagy HMGB1 MID1 TFEB ATM SHE C19orf12 PMC9148418__F6 Pharmacological modulation of healthy aging with urolithin A, NAD+, resveratrol and spermidine NRF1 SIRT1 SIRT3 PMC7966414__F1 Simplified metabolism of Lupinus albus nodules and cluster roots under P and N deficiencies CS PMC3730487__F2 Two mechanisms of phase II xenobiotic-metabolizing enzyme induction by phase II inducers MAF NRF1 AHR PMC8989838__F6 Metabolic Reprogramming of Alloreactive T Cells Through TCR/MYC/mTORC1/E2F6 Signaling in aGvHD Patients MYC PFKM HEL-S-162eP PMC3347034__F3 Inhibition of type I IFN signaling by DENV: IFNA/B binds the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 and is found on the surface of nucleated cells STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC3998185__F7 Metastatic Stem Cells: Sources, Niches, and Vital Pathways EGF CXCL1 EGFR IL8RB IL11 GPR49 PLOD2 TNC CSF1R HEY2 VCAM1 CXCR4 S100A8 CXCL9 SRC CXCL12 CSF1 SMAD1 STAT3 PMC5436704__F3 Cell–cell communication and cyclic AMP coordinates oocyte meiotic maturation in worms and mammals PDE3A VAV1 DAB1 PMC7993611__F1 Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro PC DCT TYRP1 MC1R PMC7912475__F2 Impact of Maternal Food Restriction on Heart Proteome in Appropriately Grown and Growth-Restricted Wistar—Rat Offspring AGTR1 HEL-S-28 APLN MAP2K2 ARHA ENG RRAS2 TTN ARPC2 PIKFYVE GRB2 COMP ACE2 MYLK ACTR2 PMC7088938__F4 Fusion hallmarks: trends in cellular pathways fusions by fusion event cluster ERBB4 IGF1R NGF RHO PMC7464402__F8 Apoptosis signalling pathway and cell cycle arrest in response to Moringa extract and 3-HBI BAD PAF1 BAX PMC12061513__F4 Protein palmitoylation modifications are involved in regulating osteogenic matrix mineralization and differentiation signals BMPR2 RUNX2 BMPR1A SMAD4 IFITM5 SMAD1 DKFZp781O1323 FKBP11 PMC4951290__F1 Nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells ME1 GPT DHCR24 ENO1 TM7SF2 PCCB PHGDH HEL-S-32 HMGCR MDH2 LPL SPTLC3 ME3 PCK2 PGAM1 HEL-S-133P MSMO1 FASN PMC11548906__F2 Regulation of adipogenesis in lipedema SIRT2 ADD1 FBN1 EMILIN2 SMAD4 CEBPB MRC1 CSF1R ERBB4 SFRP1 MEDAG GATA3 BICC1 CD68 LYPLAL1 NEGR1 FGF2 LIF CEBPA GATA2 SEMA6D IGF1 ACP5 CSF1 PPARG SMAD1 SIRT1 DKFZp781O1323 PMC10383192__F1 Peptide Vaccine Design Targeting KIT Mutations in Acute Myeloid Leukemia KIT BAD SRC MTOR PMC9127082__F1 Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells GPX4 SLC7A11 ALOX15 DHODH PMC7281113__F1 HOTAIR role in breast cancer (BC) drug resistance mechanisms with details of the main molecular pathways involved BAD HOXD10 TFF1 PTEN PMC7281113__F2 Main cellular processes inhibited or activated by the silencing of HOTAIR in BC cells BAD HOXD10 VCAN CCND1 BCL2 PTEN MTOR GATA3 PCDH10 PMC11632373__F1 Biosynthetic pathway of GPI-APs PIGV DPM2 PIGC PIGH PIGM PIGA PIGP PIGL PIGU PIGF PGAP1 PIGT PIGO PGAP2 PGAP3 PGAP4 PIGW PIGY PIGX PIGS ARV1 PGAP6 PIGK PIGN B3GALT4 GPLD1 CLPTM1L PMC5572180__F3 Alterations to the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway and outcome prediction in ovarian clear cell carcinoma (OCCC) PIK3R1 PIK3CA PTEN PIK3R2 PMC7852150__F1 Metabolic features of hPSCs PSAT1 ACO2 FASN PMC5228426__F2 Most highly-rated network of microRNA-1297 target genes in Ingenuity Pathway Analysis NAIP TRIM45 ELF1 CDH11 MEIS1 NTRK3 SNCAIP PTEN RB1 ZHX1 EPC1 ZNF268 MYBL1 IGF1 ATXN1 CYLD MEF2C CP PMC3642326__F7 CQ excites TRPA1 and TRPC3, sensitizes TRPV1, and inhibits TRPM8 through different signaling mechanisms TRPC3 TRPA1 TRPV1 TRPM8 PMC7015249__F9 Serum amyloid A 1 (SAA1) induced muscle atrophy TLR4 CSK RELA IL6 SAA1 TLR1 PMC9532536__F8 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway PLK1 A2M FOXM1 CCNB1 KIF20A CDC2 PMC6013765__F3 “threshold model”, as exemplified by the FGF8-FGFR system, can explain disparities in transcriptional activity FRS2 EN2 GBA2 PMC8558176__F1 WNT3 hypomethylation counteracts low activity of the Wnt signaling pathway in the placenta of preeclampsia APC GSK3B LRP5 LRP6 PMC9534556__F2 Potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry ChAT ACHE BAX PMC6602412__F2 M6A on the AKT signaling pathway PHLPP2 PRR5 MTOR PMC6602412__F3 M6A on the JAK/STAT signaling pathway STAT1 JAK3 JAK1 STAT3 PMC8458633__F8 Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway CASP3 CCNA2 CDK2 MMP9 SRC CDK4 HRAS PMC7229175__F7 BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis TLR4 MYD88 ARF3 TIRAP PMC7312764__F6 Analysis of the major constituents in SHED-CM and the plausible mechanisms of SHED-CM-mediated neuroprotective effects ROBO3 OPRM1 HOMER1 BMP5 KLC2 IGFBP2 PTEN MAPK11 IGFBP6 TGFB1 CALM1 PMC7485335__F2 ICOS signaling pathway in Tregs CXCR3 APC GSK3B CD80 ICOS FOXP3 PMC9184479__F6 Central metabolism of C. albicans is altered by L. rhamnosus colonization ALPL CS CIT MAL HEL-S-162eP PMC7827874__F2 Transforming growth factorB (TGFB) superfamily signaling in PAH NODAL TGFBR2 ARHA ID1 SMAD1 DKFZp781O1323 CDC42 PMC8093614__F1 PD-1 Immune Checkpoint Inhibitor Therapy Malignant Tumor Based on Monotherapy and Combined Treatment Research APC PMC7827874__F4 Endothelial to mesenchymal transition (EndoMT) in PAH MMP2 MMP9 VWF CDH2 PMC12245985__F7 Late‐stage DMD skeletal muscle transcriptomic changes in TGFB signalling pathway SFRP4 UNC13C ADAM12 SMAD4 SERPING1 HCAR2 SMAD1 TGFB1 DKFZp781O1323 BMP4 DMD PMC9052997__F1 An adult case of NOTCH3 mutation in pulmonary artery hypertension RBPJ NOTCH3 PMC10911275__F4 FlyBase Pathway Report pages EGFR RHO CBL PMC11667160__F6 The common upstream signaling pathways of autophagy and apoptosis under ERS ATF4 ERO1A MTOR TRAF2 XBP1 BAX PMC11667160__F4 Schematic diagram illustrating the macroautophagy process ULK1 ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 PMC11667160__F5 Schematic diagram of ERS regulating autophagy through four pathways ATF4 SESN2 MTOR TRAF2 XBP1 PMC3356354__F10 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes ITK FYN BCL10 LCK GRB2 CTLA4 LAT CBL PMC11667160__F3 ERS-induced apoptosis ATF4 ERO1A TRAF2 BAX PMC6604479__F2 Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial RFC1 TH TPH2 PMC1913583__F1 The methionine and folic acid cycles and the metabolic pathway of arsenic AS3MT HEL-S-21 PMC3963078__F7 HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors EBP AKT3 PMC9356043__F9 Virus-host interaction analysis in colorectal cancer identifies core virus network signature and small molecules DDX3Y CDK2 DDX3X DEK PMC8006014__F1 Insulin signaling pathways GIP CBL PMC8006014__F2 Pathological effect and consequence of insulin resistance PDE3B BAD GRB2 PTEN FOXO1 INSR PMC9259869__F1 Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis? IGF1R IGF1 IGFBP1 IGFBP2 IRS1 PMC2798710__F1 New roles for Notch in tuberous sclerosis TSC2 TSC1 NOTCH1 MTOR STAT3 PMC7755949__F3 Ubiquitin System and A20: Implications in Health and Disease BCL10 TRADD CYLD TRAF6 MAP3K7IP1 TRAF2 TAB3 PMC7715027__F2 Transcription regulation and consequent tissue functions in hypercapnia BCL2 ARHA CXCL12 REL TNF CXCL14 DPT PMC11784343__F6 The figure shows the PI-PLC protein, which participates in the IP3 and IP4 synthesis pathways and mobilizes calcium to regulate cell reactions and proliferation requiring free calcium RUTBC1 TWIST1 PMC5772763__F1 Aneuploid cell survival relies upon sphingolipid homeostasis SGMS1 UGCG SGMS2 PMC8814915__F1 A9-Containing Nicotinic Receptors in Cancer CHRNA9 TWIST1 PPM1F STAT3 BAX PMC7287924__F1 Model Schematic CD47 SRC CIT PMC5125867__F2 T cells in Systemic Lupus Erythematosus CD44 SYK MTOR IRF4 ICOS BCL6 STAT3 PMC6170398__F2 Central role of hepcidin in regulation of iron metabolism ERFE IL6 STAT3 PMC7824065__F6 Metabolic reprogramming to form metastatic tumors ASNS PRODH ACSS2 PHGDH PMC2922222__F1 Conserved ATR→CHK1 checkpoint signaling pathway in eukaryotes (, ) TOPBP1 ATRIP ATR PMC2517145__F1 PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells CCND1 RHO PTEN EIF4E IRS1 PMC5464836__F9 Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells TLR3 STAT3 PMC5684649__F1 Proposed salinity tolerance mechanism in Cicer arietinum L CAP2 CARF SOS2 SOS1 PMC8317254__F1 Mitochondrial and Organellar Crosstalk in Parkinson’s Disease MFN1 MFN2 LRRK2 BCL2 PMC9600485__F1 TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems APAF1 FADD BAX PMC5955615__F1 Inhibition of the dysregulated NF-kB/YY1/Snail loop YY1 CDH2 PMC5904225__F10 Schematic summary of the findings CXCL8 IL6 CCL2 IL1B PMC7933493__F1 Retinoid cycle of retina LRAT RPE65 RPE PMC8961787__F1 Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension SLC7A5 ACAT1 ACACA ACSL1 HEL-S-133P CD36 ACAT2 PMC9185072__F3 Increased serum concentrations of estrogen-induced growth factors Midkine and FGF2 in NF1 patients with plexiform neurofibroma NF1 ERG FGF2 TF PMC6454881__F6 NAD+ regulates T-cell differentiation through a novel MC-dependent signaling pathway TG GATA3 FOXP3 PMC5368067__F1 Wnt signaling pathway and targets of small‐molecule inhibitors APC LRP5 LRP6 TMEM88 DKK1 BCL9 PMC10318600__F1 Signaling pathway of ferroptosis GPX4 HEL-75 PMC9044760__F2 RIPK3-mediated necroptotic pathway TRADD TRAF2 FADD MLKL PMC7261776__F8 Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network, causing differences in pigment composition among mulberry fruits MYB CS GLS PMC5004891__F4 STING: infection, inflammation and cancer CGAS MYD88 CD8A IL1B PMC7071808__F2 Oxidative stress in TGFB1-mediated fibrosis SMAD2 TRAF6 PMC9638655__F1 Blood-based biomarkers for diagnosis, prognosis, and severity prediction of COVID-19: Opportunities and challenges VCAM1 TNF ACE2 TLR3 MADCAM1 PMC11277296__F2 Mechanisms of mitochondrial dysfunction TBK1 MFN1 CGAS MFF TRADD IRF3 HTRA2 NLRP3 MFN2 FADD FIS1 OPA1 BAX PMC8468289__F1 Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease ELF2 ULK1 SMAD2 SMAD4 ARHA PTEN EIF4E DEPTOR RHEB TSC2 TSC1 SGK1 MYOG MYOD1 PMC3857553__F2 Summary of Tim-3 expression on different innate immune cell populations and its functions TLR7 TLR9 TLR3 PMC3947657__F4 H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity DCN PKIB KCND2 ADARB1 NOX4 NTS ZNF300 FGF13 ACE2 CD36 PMC8959827__F8 PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis PDC CTRL PDK4 HMGCR PMC3794709__F1 Steps in the reverse cholesterol transport pathway PLTP ABCG1 LPL LDLR ABCA1 PMC8949885__F2 Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions BCR NR4A3 CD40 CD83 MTOR TLR10 PMC3439334__F5 WNT signalling pathway map enriched with genes up-regulated in tumorgraft-forming tumors LIMK2 PLG SMAD2 VAV1 GSK3B SHE ARHA RAC1 EIF4E MTOR HRAS MAP3K7IP1 NLK MMP7 PAK1 SRC CP CDC42 PMC4338284__F4 Molecular Characterization of the Peripheral Airway Field of Cancerization in Lung Adenocarcinoma DAG1 DUSP4 AIP DIAPH2 MAP2K1 MAP2 IFRD1 ELOVL1 USP14 FERMT2 TUSC2 B4GALT1 PMC3439334__F6 Immune response pathway map enriched with genes down-regulated in the tumorgraft forming patient tumors HLA-E MAP3K1 FOS ATF2 VAV1 SHE HRAS IFNG PMC8580479__F1 Hallmark features of cellular senescence CCL20 CCL2 MTOR PMC4838829__F4 Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations FADS2 SCD ELOVL5 ELOVL7 ELOVL6 FASN PMC3337162__F2 Polarization of migrating cortical neurons by Rap1 and N-cadherin IQGAP1 RALA RALB RAC1 RALBP1 CDC42 VAV2 PMC11206589__F1 Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies IGF1R EGFR FASN BAX PMC5649128__F1 Role of Platelet-Derived Transforming Growth FactorB1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis SMAD2 TRAF6 PMC5295401__F5 Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells FNTA RABGGTB RABGGTA PMC7015854__F2 Isolation of an archaeon at the prokaryote–eukaryote interface DCN DHDH CIT MAL PMC9956228__F2 New Insights into the Genetics and Epigenetics of Aging Plasticity SIRT2 ME1 PRDM16 ME2 KDM5B NSD2 HDAC1 KDM5A SIRT6 HDAC2 ASH1L KAT6A EZH2 ME3 EZH1 SIRT1 PRDM8 PMC9417543__F1 Microbiota and COVID-19: Long-term and complex influencing factors IL6 MTOR ACE2 ARG1 TMPRSS2 FOXP3 PMC4650145__F7 NeurimmiRs were found targeting multiple molecules of the integrin and NFKB pathway RAB21 BTK CREBBP NOD1 HEL-S-28 TRAF3 CD40 RAB5C TRAF2 MIB2 CDC42 PMC5821033__F2 TGFB/SMAD4 signaling in cancer SMAD2 ATF2 APC SMAD4 PTEN MTOR TF PMC11603854__F1 Current concept of the signaling pathway underlying the Beta-adrenergic regulation of CaV1 CS DCT PMC4696840__F3 miRNAs regulate cell metabolism by targeting key metabolic enzymes and multiple oncogenic signaling pathways TIGAR HGF EGFR PTEN MTOR HK2 BAX GLS PMC4148364__F5 Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database ME1 ND6 ND3 CENPE KEL ND4 PMC11083429__F1 When a DNA single-strand break (SSB) happens, poly (ADP-ribose) polymerase (PARP) guides SSB repair through NAD+poly(ADP-ribosyl)ation (PARylation) of histones and chromatin remodeling enzymes PALB2 FANCD2 ATM BARD1 SSB ATR CHEK1 CYP17A1 BRCA1 USP1 BRD4 PMC8061829__F1 Fungal cell wall: An underexploited target for antifungal therapies HEL-S-11 C7 PMC11206589__F2 Suggested anticancer molecular mechanisms of bromelain CDK2 CD44 CDK4 CDC2 BAX PMC11206589__F3 Suggested anticancer molecular mechanisms of sulforaphane GCLC CDK2 CD44 CDK4 PTEN IL1B CDK6 BAX PMC3866192__F1 Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure LBR DHCR7 EBP SC5D DHCR24 HMGCS1 HSD17B7 CYP51A1 HMGCR ACAT2 PMC4066667__F3 Current understanding of molecular mechanisms regulating spermatogonial stem cell (SSC) self-renewal in mice EGF FYN BCL6B LYN GDNF LHX1 ETV5 TAF4B PMC9242006__F1 Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression FGF2 HEL-S-44 FZD4 SPHK1 CD8A HEL-S-104 SYT1 IL1B CFTR PMC8216287__F4 Multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity ATM UHRF1 BRCA1 PMC5093979__F3 Genes and interaction relationship in the module 31 (a) and 35 (b) POLD2 GBP1 DKK3 GBP2 KIN AIM2 IRF2 IRF-1 POLD3 PCNA PMC5979412__F3 NFKB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role? RELA RELB MTOR PMC3852044__F3 MAPK signalling pathway CD14 MOS FLNA TRAF6 TNF NLK MAX GRB2 RAN BDNF TRAF2 MEF2C BAP1 PMC3852044__F4 Wnt signalling pathway ROCK2 NLK SIAH1 APC SKP1 ARHA PMC12183292__F3 Molecular activity of platelet-regulated T cell immune response in acquired aplastic anemia (AA) CXCR3 CXCR5 TFAM IFNG PMC11979264__F7 Mechanisms by which Met inhibits HGHF-induced ferroptosis and DOP GPX4 FTH1 SLC7A11 SLC3A2 PMC12136294__F4 Profiles of DEGs and DAMs in TCA cycle, insulin signaling pathway and Glycerophospholipid metabolism in response to diapause CS PC OGDH PMC2896553__F6 DISTINCT SPECTRUM OF COPY NUMBER ABERRATIONS IN PAEDIATRIC HIGH GRADE GLIOMAS ATM NRAS SPEN PSCA PMC8959898__F1 Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients – a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown IL10 CD14 FGF21 TLR4 CHAD IL6 TNF MTOR NR1C1 PMC4365363__F3 The major TNFR1-mediated signaling pathways TRADD CSA2 TNF TRAF2 FADD MLKL TAB3 PMC7556656__F1 NOTCH1 signaling pathway and effects of NOTCH1 mutations on CLL susceptibility to anti-CD20 mAb APC NOTCH1 SPEN ADAM10 PMC6255977__F1 Transcriptome response of Salvia miltiorrhiza to overexpression of AtPAP1 CCR2 CS CAD PMC6885903__F3 The constructed network included a main connected component and 9 isolated nodes (DEGs) RORC RSAD2 IRF8 SAMSN1 IL6 MX1 STAT1 ISG15 OASL PTPRC OAS1 OAS2 IFIT1 PMC10124776__F1 Pig heart and lung xenotransplantation: Present status HLA-E SIRPA CD47 APC GAL PMC6797571__F2 Platelet‐derived growth factors from breast cancer or neuroblastoma stimulate the platelet‐derived growth factor (PDGF) receptors and initiate immune and tumorigenesis response BAD TLR4 TLR9 BIK PCNP TLR3 PMC4287412__F9 Regulation of Wnt canonical and calcium-dependent pathway molecules in microstructured Ti surfaces WNT3A APC SOST SFRP1 ROR2 DKK1 DKK2 PMC7356262__F11 Schematic figure of the NFKB signaling pathway and inhibition of IKK complex after treatment with VA TRADD IRAK1 TRAF6 CCL5 IRAK4 MYD88 TRAF2 IL1B PMC4957332__F4 Changes in transcript abundance of genes involved in central metabolic pathways and bioprocesses in response to elevated CO2 in C-169 CS OTC ASL HEL-S-162eP PMC6851586__F1 Pathways in the pathogenesis of PSO DEFB4B CXCL1 KRT16 CXCL5 CXCL10 CXCL8 DEFB1 CXCL3 CXCL2 S100A7 HLA-C PDC CCL20 CXCL9 DEFA1B IL1B CXCL11 STAT3 PMC11873641__F1 Metabolic adaptations in cancer cells HEL-S-26 FADS2 SCD LDLR ACSS2 ACLY CD36 PMC7600801__F1 MAPK signaling pathway (A) in a BRAF inhibitor-sensitive cell showing sites of action of BRAF inhibitors and MEK inhibitors, and (B) after BRAF inhibitor resistance development NF1 BRAF MDM2 PTEN MTOR PMC11873641__F4 Intricate signaling pathways linking obesity to cancer progression IGF1R IGF1 MYC IL6 MTOR PMC5627415__F2 Epigenetic mechanisms currently associated with aortic VICs RUNX2 BMP2 MMP9 MMP16 BGLAP BMP4 ALPL MMP14 MMP2 SIRT6 opn SMAD1 TGFB1 TGFBI PMC9444135__F1 Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance VCAM1 MTOR PMC8399842__F1 Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine CYP3A4 NOS2 TNF STAT3 PMC2975200__F9 MyD88-induced protein accumulation pathways through SQSTM1 and HDAC6 SQSTM1 CYLD TRAF6 MYD88 PMC3193496__F1 Two conserved branches of the canonical Wnt pathway TCF3 HIPK2 POP1 SYS1 PMC3229036__F2 Subversion of the actin cytoskeleton during viral infection ROCK2 LIMK2 LIMK1 ROCK1 SRC F11 ARHA RAC1 CDC42 PMC3193496__F2 HIPK2 and NLK/LIT-1 in Wnt signaling NLK WNT3 TCF3 HIPK2 WNT1 POP1 TCF4 PMC4610178__F4A Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise CDKN1A CDK2 MDM2 CCND1 CDK4 RB1 CDKN2A E2F3 CDK6 CCNE1 PMC9321669__F5 Dissimilative Pathway of Komagataella phaffii (Pichia pastoris): Formaldehyde Toxicity and Energy Metabolism CTRL APP MAL PMC7885873__F1 Cytokine regulated alterations to the splenic microenvironment during experimental visceral leishmaniasis CXCL13 CCL21 CCR7 CCL19 LAG3 CXCL12 TNF NTRK2 PMC7675396__F4 Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation TFPI TNF ACE2 IL1B TF PMC5325762__F4 The DNA Damage Response During the Life Cycle of Human Papillomaviruses RAD17 TOPBP1 ATRIP ATR PMC6391454__F4 Graphic image representation of the possible mechanisms of lung inflammation in COPD involving purinergic signaling pathway ENTPD2 ENTPD3 ENPP1 ADA ENTPD1 PMC8508793__F2 RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective INA TBCE ATXN2 NMI FUS PMC5325762__F3 The DNA Damage Response During the Life Cycle of Human Papillomaviruses RNF168 ATM MDC1 RAD50 MRE11A BRCA1 PMC4304915__F6 HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism EXOC3 SRC ARHA PMC4706528__F1 PI3K/Akt/mTOR (PAM) pathway and inhibitors of the pathway tested in phase I-III clinical trials on solid tumors and/or breast cancer TSC2 TSC1 CDK4 PTEN INPP4B MTOR CDK6 PMC4491894__F3 Differential expression of a core set of genes whose products comprise a functional interactome is an underlying feature of chronically wounded RPE cells SPARC MYB dik HAPLN1 LPCAT3 FBN1 SLPI MAF DCN OAS3 LPL CENPA IGFBP7 VEGFA PIK3R3 PLCB4 SHC2 CLSPN EDNRA MCM6 PRKCB HMMR THBS2 MERTK MAPK11 LMO7 DNA2 TGFB1 FHL1 GPR68 PCSK7 BLM ADAM12 VASN LPAR1 NRP2 CCND2 FST GBP1 opn FZD7 KITLG SFRP1 THBS1 GAL PRSS1 PMCH DNM3 NTS SKA3 LTBP1 SERPINE2 NMU GALNT12 NCAPG FHL2 TYMS GLDC FANCA SMC4 SRGN INHBA TGFBI USP1 PMC9612213__F3 Molecular Mechanisms of Inflammasome in Ischemic Stroke Pathogenesis NLRP3 RIPK1 TLR4 MYD88 FADD PMC6300500__F1 Models for antigen cross-presentation mechanisms induced by adjuvants in DCs TLR4 MYD88 SNAP23 PMC33333__F2 Role of the antioxidant response element and the transcription factor Nrf2 in chemoprevention MAF NRF1 KEAP1 PMC7332907__F2 Roles of FFA2 in immune cell populations NLRP3 ALDH1A2 XBP1 IRF4 ELL STAT3 PMC3221684__F8 Insulin Receptor-Mediated Signaling via Phospholipase CG Regulates Growth and Differentiation in Drosophila EGFR SHE RHO STAR PMC4009148__F2 Signaling pathways induced by IL-17F TRAF6 RAF1 IL17RC PMC9532630__F1 Cellular loci involved in the development of brain arteriovenous malformations BRAF BMP10 ENG PMC3783562__F3 Metabolic actions of Rho-kinase in periphery and brain POMC SOCS3 NPY ROCK1 AgRP MTOR FOXO1 STAT3 PMC6812177__F1 Proposed mechanisms of inflammasome involvement in RTT OxInflammation.The scheme summarizes the basal and LPS + ATP-stimulated status of the inflammasome pathway by comparing the responses of CTR and RTT fibroblasts NLRP3 IL1B PMC7738752__F1 Omega 3 and Omega 6 metabolic pathway (from ) FADS2 ADA FADS1 PMC5397677__F1 Signaling pathways relevant to glial neoplasms in adults and children MYB BRAF PDGFRA EGFR PTEN CDKN2A HEL-S-26 NF1 MYBL1 FGFR1 PIK3CA RAF1 TERT PMC10038327__F3 Mitochondria as disease-relevant organelles in rheumatoid arthritis IL18 SLC5A12 TNF IL1B PMC140665__F8 Interaction between the Wnt/Beta-catenin and Wnt/Ca2+ pathways NLK WNT1 PMC10038327__F4 Mitochondria as disease-relevant organelles in rheumatoid arthritis HEL-S-62p RFX5 CCL18 SLC16A3 GLUD1 STAT3 PMC7591300__F1 Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? FURIN ACE2 TMPRSS2 PMC11745087__F3 Newly elucidated regulatory mechanisms relevant to RNA m6A modification (created in Figdraw) SOX2 SETD1A CTCF PSMD9 KPG_010 PARP1 MTOR IGF2BP2 SLC7A5 METTL3 IGF2BP3 TBP KHSRP PMC3193496__F4 Context-dependent function of HIPK2 in Wnt signaling LEF1 TCF3 HIPK2 PMC11745087__F2 Outline of the interplay between m6A modification and radiation-induced injury effects on distinct normal organ tissues (created in Figdraw) YTHDF2 HMGB1 METTL14 METTL3 ALKBH5 IGF2BP2 FOXO1 TIRAP PMC7488244__F1 Melatonin and urological cancers: a new therapeutic approach FADD SIRT1 PMC3458271__F2 Two proposed models of ephrin-B reverse signaling in palatal EMT based on current evidence MTOR STAT3 PMC11881903__F7 Proposed model depicting the process underlying TOD-dependent muscle regeneration PARP1 CCL2 CCL3 PMC11931045__F2 Red rectangles for upregulation, the blue rectangle for downregulation MTOR PMC12024679__F2 Notch1 pathway DTX1 MYC NOTCH1 HES4 FBXW7 PMC3712714__F1 Interaction between the vitamin D endocrine system and the inflammatory signaling pathway in control of cancer cell growth (for details, see ) NR1i1 CYP24A1 CYP27B1 PMC5504949__F2 IL-6/soluble IL-6 receptor signaling at the nexus of endocrine function: illustrative examples TH STAT1 TJP1 STC1 STAT3 PMC5665664__F6 Regulatory model of ATX expression in adipose tissue and the biological functions of adipocyte-derived ATX in diet-induced obesity LIF LPA STAT3 PMC9415106__F4 Application of Mesoporous Silica Nanoparticles in Cancer Therapy and Delivery of Repurposed Anthelmintics for Cancer Therapy YAP1 EGFR CDK4 MTOR STAT3 PMC5350572__F8 Illustration shows the proposed overall mechanism by which butyrate inhibited proliferation and induced apoptosis in hepatic cells PTEN SIRT1 PMC9452304__F1 Complete biosynthetic pathway for the production of vinblastine in yeast IDI1 IPP PMC9495847__F10 Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NFKB Signaling Pathways TLR4 KEAP1 MYD88 BAX PMC6391560__F6 Model for light input to the circadian clock network of Drosophila SLN ECEL1 PDF PMC8458276__F6 Different MMR excision-resynthesis pathways POLE PCNA PMC6532024__F6 Regulatory mechanisms of the IL-17–TRAF6 pathway TBK1 EBP TRAF3 TRAF6 USP25 PELI1 MAP3K7IP1 CARD14 BCL10 TRAF5 CYLD TRAF2 TRAF4 TAB3 PMC11943269__F4 Schematic model represents the possible RT role in adjuvant therapy for TNBC PTGR1 TTK EGFR MTOR DHODH CXCR6 STAT3 PMC8017943__F4 GA biosynthesis and isoprenoid pathway mRNAs in SRB suspensor and embryo proper regions RGL2 PMC3285038__F1 Schematic of Smads mediated TGFB signaling pathway SMAD2 TGFBR1 SMAD4 PMC6532024__F2 Receptor signaling pathways upstream of TRAF6 CARD11 BCL10 IRAK1 TRAF6 RIGI TBCEL CD40 ECSIT RIPK2 NOD2 MAVS CARD14 PMC3285038__F2 Schematic summarizing the role of signaling Smads in epithelial carcinogenesis HGF SMAD2 SMAD4 PTEN PMC6532024__F3 Inflammatory loops in the EIME of psoriasis CXCL1 BCL10 CCL20 TRAF6 IL24 CXCL2 SAA1 CARD14 PMC6886017__F6 Diagrammatic representations of putative mechanisms of microRNA 375 in regulating metadherin-induced cell proliferation, cell migration, and angiogenesis in human colorectal cancer NFKBIA PI3 BRAF NFKB1 RELA VEGFA MTDH PMC9532630__F4 Cellular loci involved in the development of brain arteriovenous malformations COX2 TLR4 IRAK1 MYD88 PMC9294167__F1 Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance SOCS3 TYK2 JAK1 STAT3 PMC6136085__F2 Persistent infections through defective viral genome immunostimulation TRAF1 TNF MAVS PMC4294505__F9 CCR7-stimulated phosphorylation-inhibition of AMPK CCL21 CCR7 CCL19 PMC5825917__F3 Means to enhance the immune response in the tumor microenvironment (TME) HGF FAP IFNG PMC12127168__F4 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways BAD GAB2 CCND1 JAK1 BAX PMC12127168__F5 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways HHIP SUFU PTCH1 SHH SMO PMC8049868__F1 Recognized pathways of androgen biosynthesis in prostate cancer CYP11A1 AKR1C2 CYP17A1 STAR PMC12127168__F2 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways TRAF6 MYD88 TRAF2 PMC4023177__F3 Key signaling pathways involved in the early recurrence/metastasis (R/M≤6months) and late recurrence/metastasis (R/M6-12months) of H-HCC CEBPE HNRNPAB GLB1 SMPD2 POSTN HEL-S-99n F2RL1 MAOA APOC3 RB1 IFNG PRKCA PRTN3 HEL-S-78p SREBF2 CD209 SRC CYFIP1 OPA1 FGA PPL HNF1A DIABLO GPLD1 PLAA FXR1 SOAT1 ALDH3A1 CASP4 MUC1 PIG59 MPO NUPR1 DPP4 OSCAR IPO5 ACHE LGALS4 KANK2 HSF1 SNX33 CLU CORO1A TIMM23B CEBPD CRP SNX2 LDLR APP KNG1 NR1H3 APOA2 FASN BAX PDGFRA IL13 SSB SPDEF MBL2 ANGPT1 ITGAM GHRL TNFSF10 CTSC RELA APOL6 TOMM40 STAT3 PMC12127168__F3 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways ZNRF3 APC PMC12127168__F8 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways MAF KEAP1 NQO1 PMC4327859__F1 TLR4/NFKB signalling pathway and TLR4/ MAPK signalling pathway in gastrointestinal epithelium TLR4 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 PMC9469633__F8 Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer WNT7A MTOR PMC12127168__F6 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways STAT2 GRB2 TYK2 JAK1 PMC4968087__F7 ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE SIRT2 MDM2 PARP1 SIRT1 BAX PMC3902845__F2 Multiple changes in gene expression influence KRAS activity, the KRAS downstream pathway and cell growth occur during development of a “mature” PDAC cell EGF EGFR TGFA PMC3969038__F1 NFKB signaling pathway and cancer related mutations CARD11 BCL10 RELA MYD88 PMC2064840__F9 Divergent TGFB signaling pathways induce transcriptional regulation through Smads and translational regulation through the mTORC1 pathway SMAD2 SMAD4 PMC12019327__F7 Mechanism of anticancer action of salinomycin and oxaliplatin cotreatment against CRC cells CASP3 CASP9 BAX PMC5462861__F1 Nrf2 activation by misfolded proteins KEAP1 PMC12021879__F1 Mechanistic map of metabolic bone disease: The pathogenesis of MBD primarily involves four key pathological dimensions: abnormal bone resorption, abnormal bone formation, abnormal mineral deposition, and metabolic factors FGF23 NFATC1 LRP5 LRP6 PTH SMAD1 DKFZp781O1323 PMC10451275__F3 Changes in subcellular localization of Ras upon S-nitrosylation SRC HIF1A HRAS PMC5400663__F1 Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas EGF EGFR MTOR SMAD1 DKFZp781O1323 PMC7699726__F2 KEAP1-NRF2 modulation in cancers such as RCCs TSC2 PRCC TSC1 FYN BRAF KEAP1 FH MYC VHL CSA2 MTOR SIRT1 PMC2902148__F2 Inhibition of VEGF signaling pathways VEGFC VEGFA VEGFB PMC2902148__F1 VEGF signaling interactions PIGF VEGFC NRP1 VEGFA VEGFB NRP2 PMC4255606__F4 Proposed role of stem-progenitor cells in leiomyoma pathogenesis HMGA2 MED12 PMC8463536__F3 P53 family members, such as p53, p63, and p73, some transcription factors, such as SP1 and CREB, and noncoding miRNAs, such as miR-144, miR-885-5p, and miR-101 regulate the transcription of TIGAR TIGAR MYC NSD2 SP1 HIF1A PMC3422654__F1 Genes Associated with Outcomes in the Context of Two Fatty Acid Metabolism Pathways AGPAT3 ACSL1 MLYCD ACSL3 PMC8463536__F4 Enzymatic activity of TIGAR TIGAR PMC9220138__F4 Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls NF2 CPT2 ACLY TFAM SLC25A1 FASN CD36 PMC5984538__F4 NFKB and Wnt signaling pathways NGF TRADD APC GSK3B LRP5 TRAF3 LRP6 TNF MAP3K7IP1 MAP2K6 NLK LTA TRAF5 ATM BBC3 BIRC3 AXIN2 TRAF2 IL1B TAB3 PMC5864212__F6 Deciphering the nature of the coral–Chromera association CD63 EEA1 PMC10453069__F4 DNA repair pathways of DNA double-strand breaks PALB2 FANCD2 BLM NBN PARP1 MRE11A BRCA1 WRN RBBP8 ATM BRCA2 TOPBP1 RAD50 RAD51 FANCA ATR FANCF PMC6925091__F5 Necroptosis is an example of antagonistic pleiotropy RIPK1 RIPK3 MTOR ZBP1 MLKL PMC6558469__F1 Mechanisms of tumor progression and tumor microenvironment‐mediated immune evasion in classic Hodgkin lymphoma (cHL) CD163 CD40 PMC10453069__F2 ATM- and ATR-mediated pathways in the presence of damaged DNA WEE1 ATM TOPBP1 TP73 CDC2 ATR H2AX PMC10453069__F3 Excision repair pathways of DNA single-strand breaks XPC LIG1 PMS2 APEX2 MLH3 AGA APEX1 MSH6 ERCC1 MSH3 MSH2 OGG1 PCNA PMC8122702__F2 NRF2/KEAP1 Signaling Pathway in Cancer Metabolism KEAP1 RBX1 PMC10453069__F1 Clonal evolution of plasma cell dyscrasias BRAF ATM MYC PMC9189267__F3 Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19 NLRP3 HMGB1 IL1R1 AIM2 MAVS GSDMD PMC4763179__F1 Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation BMPR2 USP45 BMP2 SMAD4 SMAD1 DKFZp781O1323 PMC3379801__F8 p16-Cdk4-Rb signaling pathway diagram CDKN2B CDK4 CDKN2A CDK6 PMC6220384__F1 HMBG1 and inflammatory and immune processes HMGB1 TLR4 CXCR4 CXCL12 STAT3 PMC4012967__F1 IL-6/JAK/STAT pathway EGF RET SOCS3 EGFR CCND1 SRC IL6R STAT3 PMC4294374__F1 Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat PCSK9 IGF1 LDLR LRP6 MTOR TG PMC6220384__F2 HMGB1 and Fas/FasL signal pathway in uveitis HMGB1 VCAM1 PMC2731131__F10 Schematic summary of LPS-triggered programmed cell death in human endothelial cells TLR4 MYD88 FADD PMC4285107__F1 New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish SHH PMC4107064__F1 Progress in Central Nervous System Lymphomas IL10 IRAK1 MYC IRAK4 MYD88 CXCL13 BTK PIM1 TLR4 BCR BCL2 JAK1 IL4 CXCL12 STAT3 PMC8518013__F7 Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma SMO PMC6530347__F2 Overview of thyroid hormone (TH) production, transport, activity and regulation DIO1 NR1A2 THRA PMC11380518__F3 Biosynthesis of the IPP and DMAPP via the MVA pathway (purple) and MEP pathway (green) MVD MVK IPP PMC8642962__F6 Novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/Beta-catenin signaling pathway DKK1 PMC3959773__F1 Mitochondrial respiratory chain COQ3 COQ2 COQ9 COQ6 CPT2 PDSS1 PMC12193433__F4 IL-6/JAK/STAT3 signaling pathway and oleocanthal-mediated inhibition MMP2 CCND1 JAK1 STAT3 PMC2624576__F1 Alternative splicing in the NFKB signaling pathway TRADD CYLD IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TNF MAP3K7IP1 TRAF2 TIRAP PMC12193433__F3 Schematic on HGF/C-Met signaling in mesenchymal cells, activating RAS-ERK, RAC1-JNK, PI3K-AKT, and STAT3 pathways to regulate cellular processes HGF GRB2 SHE RAC1 MTOR STAT3 PMC5946030__F2 Mitochondrial DNA mediates pro-inflammatory response TBK1 CGAS TLR9 DNASE2 IRF3 MYD88 TNF PMC2999098__F3 CKI members in canonical Wnt signaling TCF3 FOS APC JUN PMC2765788__F6 STRIATAL NEUROPROTECTION WITH METHYLENE BLUE STH CP PMC4327859__F4 Post-transcriptional gene suppression mediated by miRNAs is involved in the fine-tuning of epithelial anti-Cryptosporidium defence TLR4 CX3CL1 SNAP23 PMC4041145__F1 Akt and NFKB signaling in drug resistance mechanism of tumor cells COX2 BAD MDM2 PMC7105577__F2 Crosstalk between major signaling pathways during nephron progenitor cell (NPC) differentiation ALK APC GSK3B GRB2 SFRP1 LATS1 DKK1 AXIN2 LATS2 FAT4 PMC6854009__F4 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Infected Subjects (–) CNTF EDAR EGF NGF BCR DAO CYLD TNF ELL PMC8466445__F1 Anti-Viral Pattern Recognition Receptors as Therapeutic Targets TBK1 CGAS TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 TNF TLR3 TLR8 KL BTK TLR7 MAVS PMC3413411__F1 PI3K-AKT-mTOR signaling pathway PI3 TSC1 PTEN MTOR DEPTOR IRS1 SGK1 RHEB MLST8 PMC6854009__F5 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Vaccinated Subjects (–) CNTF EDAR EGF PC NGF BCR DAO CYLD TNF ELL PMC7642822__F8 Regulator effect networks generated by Ingenuity Pathway Analysis (IPA) in MCF7 over-expressed mitochondrial fission factor (MFF) ROCK2 MUC1 CD14 ADD1 CCNA2 RPA1 KRT19 ARHA RB1 ITGB1 PARVA CLU NFKBIA MAP2K1 TYMS CCND1 PXN SVIL FASN BAX PMC3652384__F2 The mechanism of late PC STAT1 LCK SRC JAK1 STAT3 PMC11852910__F4 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies AMOT AXIN1 PARP1 PTEN BRD7 MAVS SOX9 PMC7160658__F1 Checkpoint inhibition‐induced adverse events APC CD80 PMC11852910__F5 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies PARP1 RNF146 HIF1A TNKS2 PMC5657403__F1 Regulation of the intrinsic pathway to apoptosis by B‐cell‐lymphoma‐2 (BCL2) family members BAD BIK BCL2 MCL1 BMF HRK BAX PMC5344425__F1 Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? F2 GSK3B TNF PMC4075482__F5 Pathway Analysis NDUFA5 NNT OGDH HEL-S-87p DLAT PMC2655983__F3 Simplified version of colorectal-cancer biological pathway in KEGG database for genes with mutation data in COSMIC PI3 BRAF APC SMAD4 PMC7726150__F6 How Lrp6-APEX2 may interact with the ESCRT machinery and TFG in multivesicular body formation during Wnt-induced endocytosis APEX2 TFG PEX2 LRP6 PMC4563120__F5 The acute phase response is not generally up regulated in patients with < 14 mo survival FGA HAMP TRADD FOS TNF MTOR ECSIT TRAF2 JUN CP TF HRK STAT3 PMC7400809__F4 Action of TET inhibitors MEIS1 SP1 STAT3 TET1 PMC10741130__F6 Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer TSC2 BAD TSC1 HGF MDM2 CASP9 CCND1 EIF4E PMC7866084__F1 NLRP3 inflammasome activation in AD and PD with potential intervention of natural extractions NLRP3 FYN TLR4 MYD88 CD36 PMC8456397__F2 Molecular Insights into the Crosstalk Between Immune Inflammation Nexus and SARS-CoV-2 Virus STAT2 IRF9 IRF3 TYK2 TLR3 PMC8891531__F1 Trained Immunity: An Overview and the Impact on COVID-19 ATF7 TLR4 TNF MTOR IL1B NOD2 PMC3705551__F2 Major catabolic and anabolic pathways in mammalian cells CS SLC5A1 CIT HEL-S-133P MAL PMC11242417__F3 Signaling pathways of macrophage polarization SOCS3 TRAF6 IRAK4 STAT1 TLR4 STAT4 NOTCH1 TYK2 JAK3 JAK1 ARG1 SOCS1 STAT3 PMC9553197__F2 Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective CASP3 MMP2 MMP9 EGFR CASP9 PTEN RAC1 MTOR BAX PMC11242417__F1 Macrophage origins and biological functions BCR TNF ARG1 PMC8222483__F2 Linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target? SMAD2 SMAD4 SRC RHO LPA TGFBR3 PMC5700507__F2 Immediate immune responses of pulmonary resident cells to RSV infection in neonates CXCL1 PDC IL33 TSLP PMC7785737__F3 Wnt signaling pathways APC GSK3B LRP6 CDC2 PMC3193874__F2 Caloric Restriction and Chronic Inflammatory Diseases IGF1R PTEN IRS1 PMC6916499__F1 Retinoid transport and transformations in vision LRAT RPE65 RDH5 PMC7856191__F8 Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. BCR CD22 SHE SLAMF7 PMC6434111__F1 l-Arginine de novo synthesis pathways OTC CIT PMC3103318__F7 Model pathway for genistein-induced ASAH1 transcription in MCF-7 cells CCNB2 ABCC1 ABCG2 SP1 PMC3693188__F1 TP53-centered network in CLL: A novel pathogenetic model for chronic lymphocytic leukemia (CLL) showing a pathway of microRNAs and cytogenics that are involved in the development of CLL ATM ZAP70 MDM2 BCL2 MCL1 PMC3484676__F3 Rbf1 occupies multiple nodes in conserved signaling pathways TSC2 TSC1 MIB1 SIK2 APP SPEN PTEN FURIN WBP2 PARL RHEB NEDD4 PMC2253531__F5 Induction of immune response to Wolbachia infection in S2 cells MYD88 TUB REL FADD PMC4751644__F1 PI3K signaling and common mutations related with ASD and schizophrenia NF1 ERBB4 PTEN EIF4E FMR1 DEPTOR BDNF RHEB PMC1622889__F1 Anti-apoptosis of families of HSPs BCL2 BAX BOK PMC8799861__F6 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy PDE3B CGAS TLR4 IRF3 TLR3 PMC5983771__F1 Intracellular immune ecosystem in a virus infected cell STAT1 TLR8 TLR5 TLR7 TLR4 TLR9 STAT2 IRF9 IRF3 MYD88 TLR3 MAVS PMC8799861__F5 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy CGAS IRF3 LATS1 LATS2 TF GSDMD PMC11655944__F2 Antitumor effects mechanism of EH TLR4 MMP2 ATF4 MMP9 MYC CCND1 TNF XBP1 IL1B STAT3 BAX PMC11655944__F3 Main components of EH Antitumor’s effects mechanism PLK1 CDK2 SMAD2 EGFR SMAD4 MTOR CDK6 STAT3 BAX PMC4771656__F7 Signaling pathway of SFN in U251MG cells BAD SFN BCL2 BAX PMC9563115__F1 Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy TLR4 HGF MSC IRS1 STAT3 PMC3139800__F1 Regulation of endonuclease activity in human nucleotide excision repair POLK XPC XPA PCNA PMC10954797__F2 Graphical representation of stress signal-mediated dysregulation of p53 expression during progression from colitis to cancer ATM ATR PMC7873640__F1 Detail description of both canonical and noncanonical TGFB signaling and interaction of natural compounds in the regulation of this signaling cascade at various levels SMAD2 GRB2 MTOR TF PMC3918130__F5 Adenovirus elicits IFNAB production by a novel viral induction pathway TLR7 TLR9 IRF7 IRF3 MYD88 TLR3 PMC11966486__F1 CD28 signaling motifs mediate co-stimulatory signaling to regulate T cell function ITK APC LCK VAV1 GRB2 IL2 CD80 PMC5836070__F2 Ethanol indirectly interferes with DNA integrity by affecting key points (labeled in red) or enzymes in folate metabolism HEL-S-61p MTR DHFR PMC6867841__F7 Schematic picture depicting the effect of the immune factors on cysticercal brain infection IL18 TRAF1 TRAF3 TRAF2 PMC10954797__F4 ERCC4 may serve as an important regulatory factor for the upregulation of PD-L1 expression induced by DNA damage signals and DDR defects ATM ATR PMC7457324__F3 Metacore analysis reveals the top scored network of IL-6 pathway A2M HP HEL-S-92n JAK1 APOH SAA2 STAT3 PMC6606335__F5 Phase I/II Trial of Carfilzomib, Pegylated Liposomal Doxorubicin, and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma BAD OMP HRK PMC7027163__F1 MAPK cascades APP SP1 PMC4599573__F8 PLB regulates remodeling of epithelial adherens junctions pathway in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis HGF APC RAN PMC9158441__F5 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms MEI1 ATG3 APAF1 CDK2 ATF4 MAP3K7IP1 XBP1 FADD BAX PMC4580090__F1 Role of STAT3 in lung cancer EGFR SRC IL6 STAT3 PMC2953497__F9 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells CES2 XPNPEP2 IFITM3 BST2 IL6 CTLA4 SIK1 GPX3 ANKRD29 TULP2 AP1S3 NLGN3 TNFSF12 ACP5 ABCG2 SNCB TPT1 SAP30 PMC6110912__F2 Summary of roles of different DUBs on the development of cardiac hypertrophy USP4 USP14 CYLD USP18 PMC3547902__F2 Autocrine functions of VEGF in breast tumor cells SEMA3A ASB1 NRP1 NRP2 PMC4599573__F5 PLB regulates death receptor signaling in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis CASP6 LIMK1 TRADD ROCK1 TNF LMNA DIABLO GAS2 DFFB DFFA APAF1 TRAF2 FADD ARHGDIB PMC6110912__F1 Summary of roles of different E3 ligases on the development of cardiac hypertrophy TRIM32 TCAP TRAF3 MDM2 TRAF6 MTOR TRAF2 FOXO1 PMC4899619__F1 TGFB/Smad canonical signaling pathway BMPR2 BMP2 ACRV1 SMAD4 PMC4599573__F2 PLB regulates cell cycle at G2/M checkpoint in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis CKS2 ATM RPRM DKFZp781B1423 C13orf34 CDC26 BRCA1 AURKA CDK7 PMC10704547__F2 AhR ligand-activated pathways mediate pro-cancer activities in breast cancer cells SAMD3 CYP1B1 EBP MMP9 RELB PTEN PAH STAT5B TDO2 AHR KYNU MMP2 CCND1 CYP1A1 PMC7912808__F6 Ingenuity pathway analysis of processes related to Barrett’s transcriptome TLR4 SMARCA4 HNF4A CIP2A SPINK1 BIK HNF1A CEBPA RHO PMC4599573__F1 Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells ARHA RHO MTOR ELF4 PMC1978064__F4 MiR-103/107 and PANKs may constitute coordinated transcription units with synergistic cellular effects concerning cellular acetyl-CoA levels and other metabolic pathway elements PDPR PANK3 LRP11 GLS2 ACSL1 EGFL8 LRP6 PISD ACLY PDK4 ACOX1 FASN PMC10704547__F1 AhR ligand-activated pathways mediate anticancer activities in breast cancer cells AHR CYP1B1 NOTCH1 CDK4 CYP1A1 CYP1A2 SOX4 BAX PMC7998316__F3 Simplified scheme highlighting processes in which PD-related proteins function in the endo-lysosomal pathway VPS35 PLA2G6 VPS29 PMC5605239__F6 Model for avoidance of APOBEC-induced lesions ahead of lagging strand DNA synthesis REV1 GC PMC2834757__F9 Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users STAT1 STAT4 TYK2 RB1 IL12RB1 STAT3 PMC2653380__F3 Schematic representation of bile acid synthesis by the classical neutral pathway CYP27A1 AMACR AKR1C4 BAAT HSD3B7 PMC10704547__F4 AhR ligand-activated pathways/genes exhibit anticancer or pro-cancer activity in breast cancer cells AIP AHRR AHR MMP2 CXCR4 MMP9 KLF4 CCND1 SOX4 BAX PMC7004529__F1 Characteristics of cellular senescence CDK2 CDK4 CDK6 PMC4302918__F3 Metabolic crosstalk between key signaling pathways in stem cells via ROS and other metabolic co-factors FOXO3A PTEN SIRT1 UCP2 PMC7004529__F2 Biological function of senescence‐associated secretory phenotype (SASP) factors in physiological and pathological conditions CXCL1 CCL5 CCL2 PMC7004529__F3 CGAS‐STING pathway in senescence‐associated secretory phenotype (SASP) regulation TBK1 CGAS IRF3 PMC7214151__F3 Interaction between Rap2‐Hippo‐Yap1 pathway and TGF‐B signaling HTRA1 SMAD2 TGFBR2 SMAD4 LATS1 DDR2 LATS2 PMC7460797__F2 1,25(OH)2D3 exerts neuroprotective effects via GDNF RET NR1i1 GDNF GFRAL PMC8566155__F1 Clinical Features and Pathophysiological Mechanisms of COVID-19-associated Gastrointestinal Manifestations IL17A CCL25 MTOR TMPRSS2 PMC7243420__F2 From Beyond the Pale to the Pale Riders: The Emerging Association of Bacteria with Oral Cancer NLK ZEB2 FOXO1 PMC6217750__F4 Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs HDAC3 NCOR1 GSK3B ZNHIT1 RORA HDAC1 PMC8220152__F3 Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential USP4 USP15 NFATC2 USP14 MDM2 BMI1 USP22 STAT3 FOXP3 PMC3651593__F1 Pathway of Fbw7-mediated degradation UBC SKP1 RBX1 PMC9342591__F1 Cast of characters IL18 IL6 WNT10A TGFB1 WNT7B PMC3392150__F1 Unfolded protein response and its role in intestinal homeostasis and inflammation ATF4 EIF2A UNK ATF5 TRAF2 PMC12131435__F8 Intricate signaling interactions between cancer-associated fibroblasts (CAFs) and cancer cells, highlighting key pathways involved in tumor progression, proliferation, migration, and metastasis EREG HGF NODAL CXCL5 BMP2 SMAD2 POSTN IGF2 EGFR CD44 PTEN MTOR VCAM1 GFER CXCL12 PMC6340935__F1 The hexosamine biosynthetic pathway (HBP) leads to UDP-GlcNAc formation and regulates O-GlcNAcylation OGA OGT PMC10253447__F1 Notch signaling pathway inhibition leads to intestinal differentiation RBPJ ATOH1 MUC2 HES1 PMC5289527__F6 Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility IL6 PMC2756960__F8 Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs IGF1R IGF1 HEL-S-67p TXNIP PTEN MTOR IRS1 PMC4303637__F1 Metabolic reconstruction for Candidatus Iainarchaeum andersonii genome AMH MSC FES CIC PMC4899619__F2 Multiple TGFB signaling pathways GRB2 SHE ARHA CDK4 MTOR ADRBK1 PMC4899619__F3 TGFB and tumor suppression E2F4 GIG8 APAF1 CDK4 BMF DIABLO CDK6 PMC4438421__F3 TLR-ligand-mediated NFKB activation TBK1 TRAF3 TRAF6 IRF3 MYD88 TIRAP PMC6814613__F8 Proposed signaling pathway of the study PDGFRA EGFR NINJ2 PMC8777033__F3 Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites PIG59 MALL CIT RPE MAL PMC10253447__F2 Hedgehog signaling pathway in the development of intestinal metaplasia in the distal esophagus DHH PTCH2 IHH SMAD4 HEL-S-116 MUC2 SOX9 BMP4 FOXA2 CDX2 SUFU PTCH1 SHH SMO SMAD1 DKFZp781O1323 PMC11767263__F1 Exercise alleviates sarcopenia by regulating multiple signaling pathways MFN2 IGF1 UCP1 APC GSK3B FNDC5 RHEB PMC5253284__F2 The unique biochemical aspects of MET-mediated bypass signaling driven by cell surface RTK aggregates leading to de-coupling of EGFR oncogenic function from its tyrosine kinase activity (alternate signaling) HGF EGFR PTEN MTOR STAT3 PMC4778288__F5 CRHR1 alterations in CRPS patients and schematic representation of miR-34a mediated repression of CRHR1 regulating POMC expression and BMI a CRHR1 was significantly higher in poor responders than in responders POMC PMC6220113__F4 Illustration of lipoprotein alterations in chemotherapy recipients after 6 months LPL TG PMC6321489__F3 Scheme of the main steps for autophagy and their regulation by AMPK ATG12 ATG3 ATG101 ATG10 DEPTOR PMC3166463__F1 RIGI-like receptor pathway TANK IRF7 TRAF3 TRAF6 RIGI IRF3 MAVS PMC12131435__F2 Process of normal fibroblasts transforming into CAFs can be described as follows: a Growth Factor and cytokine stimulation EREG YAP1 SMAD2 FAP IL33 SMAD4 SRC SKI SOCS1 IGF2R STAT3 PMC7109323__F6 Inhibition of PRRSV by LPS TLR4 CD163 ADAM17 PMC3166463__F3 Innate immune signalling at the mitochondria NLRP3 IL16 TLR4 IRGM NLRX1 TRAF6 ECSIT TLR1 MAVS PMC4534527__F1 Illustration of sonic hedgehog (SHH) signaling pathway SUFU PTCH1 GLI3 SHH CCND1 SMO PMC7765927__F2 Suggested interaction model between EBV and P CXCL1 MMP2 CXCL5 MMP9 MTOR PMC12131435__F1 Various regulated cell death mechanisms—ferroptosis (1), cuproptosis (2), and necroptosis (3)—influence the tumor microenvironment (TME) by shaping immune cell populations and modulating tumor progression ASAH2 GPX4 APC PMC3913057__F3 ErbBs/EGFR(s) signaling pathways FOS MYC GRB2 RAF1 JAK1 SP1 JUN PMC8620049__F1 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers KIT NRAS BAX PMC8620049__F2 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers SUFU PTCH1 SMO BAX PMC3936782__F2 Neuroprotective/apoptotic intracellular cascades at baseline and as mitigated by mood stabilizers in BD BAD APAF1 CAD BDNF BAX PMC3820259__F2 Roles of lipids in the tumour microenvironment LPA HEL-S-104 FASN PMC8870715__F1 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements EGFR MDM2 CCND1 PTEN MTOR PMC8869227__F4 Cytoplasmic and Nuclear Functions of cIAP1 TLR4 TRADD TRAF3 CD40 MYD88 MAP3K7IP1 TRAF2 CDC42 TAB3 PMC11724356__F2 NSCLC immunotherapy resistance MTAP BRAF EGFR STK11 LAG3 B2M MTOR CDKN2A STAT3 PMC8276205__F3 PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury PLCG1 ZAP70 MTOR STAT3 FOXP3 PMC7662834__F7 Insulin signaling pathway TSC2 BAD TSC1 INS RHEB INSR PMC7576823__F3 Talin1 plays significant roles in cancer related pathway HEL-S-28 SRC RHO MTOR JUN PMC11666973__F6 Pattern diagram of H9N2 PB1 regulation of the RIG-I signaling pathway TBK1 IRF3 TRIM25 MAVS PMC8870715__F2 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements FADD BAX PMC8870715__F3 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements LAMP2 UVRAG MTOR ATG14 SIRT3 PMC8573224__F5 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment PTS CS ADA CIT TNLG7C RPE HPR MAL HEL-S-162eP PMC7364809__F2 Signaling pathway of SGK1 in oncology TSC2 RANBP1 GSK3B MDM2 JUNB SP1 IL23R SGK1 FOXO1 RHEB GATA3 FOXP3 PMC6600269__F1 Survival signaling pathways related to the PI3K/Akt pathway in mouse macrophages TSC2 BAD TSC1 BCL2 PTEN RHEB PMC8573224__F4 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment PTS CS CIT TNLG7C RPE HPR MAL HEL-S-162eP PMC5056247__F1 Mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3 kinase (PI3K) pathway with downstream effectors TSC2 BAD TSC1 MDM2 GRB2 PTEN RHEB PMC4199593__F5 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana HEL-S-62p F10 PROS1 THBD F8 F9 PROC F2 F5 F3 VWF F11 F7 C1S PMC4767459__F2 Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer TSC1 BRAF PTEN EIF4E HIF1A MTOR EIF4B IRS1 RHEB PMC4199593__F6 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana TBK1 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 MTOR MAP3K7IP1 TLR3 STAT1 TLR8 PIM1 TLR7 ECSIT FADD TIRAP MAVS PMC4905168__F1 Noxa and cancer therapy FOXO3A ATF4 HEL-117 BAX PMC7210406__F7 Proposed pathway of kynurenine effects on BMSCs IDO1 HDAC3 NCOR1 AHR CXCR4 CXCL12 PMC4199593__F7 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana CASP3 CASP6 NGF ATM IL3 APAF1 BCL2 PTEN CASP10 CASP8 BAX PMC9476726__F9 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer SMAD2 MTOR PMC7827270__F2 Action of Oxaliplatin: L-OHP is transported into the cell by solute carrier family 31 (copper transporter), member 1 (SLC31A1) ERCC1 ERCC2 SLC31A1 HEL-S-22 PMC9476726__F7 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer LATS1 RHO LPA PMC3894232__F3 JAK2-STAT5B pathway and osteoblast differentiation RUNX2 GHR PMC4776098__F1 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina MYB PRKCZ NPM1 FLT4 MYC HSPD1 HIF1A MYH10 RPSA PRKCA STAT1 VAV3 KDR GRIN1 SRC HNRNPA2B1 MAPK1 EZH2 CDH2 DAB1 TRIO SNCA AKAP12 STAT2 VEGFA FOXO1 MCM3 PLCB2 RET PAK1 MCM2 KHDRBS1 TSHR CXCR4 GRB2 TYRO3 SGPL1 OTX1 HEL113 CXCL12 ITCH MYH9 PLCG1 CHUK CCR3 BRAF RUNX2 PTN HSP90AB1 EGFR HEL-S-101 HEL-S-15 MTOR HEL-S-2a CDC2 HEL-S-77 RGS16 PPIC FASN RORC FOXO3A PDGFRA VHL DDX3X NR3C2 MAP2K2 HEL-S-87p ID1 PRKD1 ID3 MAP2K1 PIK3CA RAF1 STAT3 PMC9476726__F5 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer EPOR COX2 EPO STAT2 GRB2 TYK2 MTOR PMC4776098__F2 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina CHUK CCR3 NPM1 ROCK1 EGFR MAPK3 MYC CCL5 HIF1A MTOR RPSA STAT5B FYN HTT CCND1 HNRNPA2B1 MAPK1 CDH2 RGS16 EN1 AXL FASN PRKCI HEL-S-89n FOXO3A YAP1 FTH1 CSK CDKN1B VHL CCR4 DDX3X HEL-S-87p IRS1 IKBKB PAK1 MMP14 CXCR4 BCL2 HEL113 ITGAV SPHK1 RAF1 CXCL12 SHC1 STAT3 PMC9476726__F6 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer HHIP SUFU PTCH1 SHH SMO PMC9476726__F3 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer EGF BAD PDK2 EGFR PTEN MTOR PMC9476726__F4 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer ZNRF3 APC GSK3B PMC3587995__F2 p53/p21/pRb/E2F and p16/pRb/E2F signaling pathway MDM2 CDK4 BMI1 PMC9476726__F2 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer COX2 TRADD ECSIT MYD88 TNF TRAF2 FADD PMC3894232__F2 JAK2-STAT5B pathway and osteoblast differentiation IGF1 GHR STAT5B PMC4824608__F1 Various possible mechanisms of Ca2+-ITPR-mediated control of autophagy ULK1 TFEB BCL2 ULK2 MTOR MCOLN1 PMC9008778__F4 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C NLRP3 IL18 PC PF4 VWF TF PMC9008778__F5 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C TSC2 NLRP3 TSC1 PC APC PARP1 IL1B PMC4377021__F10 Relevant crosstalk of altered signaling pathways involved in cell death for PTC and ATC TIMP1 S100A10 ANXA2 PIAS1 GATA6 S100A4 NRP2 PMC8934861__F5 Analysis of Gene Expression Profiles in the Liver of Rats With Intrauterine Growth Retardation FABP2 UBC PLTP UCP1 AQP7 HEL-S-28 LPL HEL-S-104 FABP1 PMC4606863__F1 Eicosanoid Storm in Infection and Inflammation COX2 COX1 LTB LTC4S TRPA1 TRPV1 PMC9124149__F1 Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope MFN1 MFN2 FIS1 PMC4459756__F3 Risk loci of human autoimmune diseases associated with the TFH developmental pathway TH IRF8 STAT4 CXCR5 CD80 IL12A IL23R IL12B PTPN22 ICOS STAT3 BATF PMC4606863__F3 Eicosanoid Storm in Infection and Inflammation NLRP3 COX2 TLR4 IL1B PMC3420349__F1 P53 signaling pathway: In normal conditions (black arrows), p53 is maintained at very low levels ATM MDM2 ATR PCNA BAX PMC8117096__F3 CGAS-STING Pathway: Novel Perspectives in Liver Diseases TBK1 CGAS IRF3 PMC5412459__F1 Isotopomer formation through carbon distribution of [1,2-13C2]-glucose PC CIT HEL107 MAL PMC5296735__F5 Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease CXCR1 CXCL16 FOS CSF3R IL8RB CSF2RA BCL6 PMC7661711__F2 PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation BCL2 PKD1 RPS6 MTOR PTRH2 BAX PMC6584781__F1 Signaling pathways that converge on p38 mitogen-activated protein kinase (MAPK) activation and formation of plexiform-like lesions in pulmonary arterial hypertension (PAH) VEGFC MMP9 TG TSN STAT3 PMC7816286__F6 Potential signaling pathway by which CD90 regulates biological behavior and energy metabolism in gastric cancer cells SIRT2 SIRT6 MDM2 PTEN SIRT1 SIRT3 PMC7186402__F1 Classic control network of ferroptosis NOX3 GCLM VIT LPCAT3 STEAP3 FACL4 SLC7A11 GCLC CISD1 HMGCR HEL-S-102 HEL-S-64p PCBP1 GSC SLC3A2 PMC8382288__SF1 Dual regulation of osteoclastogenesis and osteogenesis for osteoporosis therapy by iron oxide hydroxyapatite core/shell nanocomposites BMP6 BMP2 NFATC1 MSC SMAD6 TRAF6 PMC8992566__F1 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms CORT TBP PMC8992566__F4 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms SOX2 MAPK4 LTB SRC CD40 ONECUT2 PTEN EZH2 RB1 AURKA STAT3 PMC3549674__F1 New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus TSC2 TSC1 IGF1R EGFR GSK3B CCND1 SRC PTEN DEPTOR RHEB PMC8879274__F1 Potential to Fight Obesity with Adipogenesis Modulating Compounds PDGFRA SAG UCP1 PPARGC1A LRP5 LPL SMO CEBPA PPARG PMC7354287__F7 Androgen-binding AR inhibits TGF-Beta-related Pathway SMAD2 SMAD4 PTEN PMC11572637__F1 Elafibranor on alcohol-associated liver disease in mice TLR4 HEL-S-44 NR1C1 PMC7565591__F3 Coupling of signal transduction and (default) pathways affecting mRNP formation and mRNA fate EDC4 DCP2 TRAF6 XRN1 DCP1A PMC2999229__F1 Hypothetical model for the molecular signaling pathways of vasculogenic mimicry in tumors and anti-vasculogenic mimicry (VM) therapy strategies GIG8 MMP2 NODAL GAL EPHA2 BEX2 PMC10379376__F2 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells SLAIN1 TCF3 DAZAP2 SOX2 LEFTY1 NODAL LEFTY2 CDK6 TOB2 CCND2 CCND1 CDK4 MBD2 PMC5399913__F3 Anti-recombination and anti-crossover activities of Srs2 during replication and HR mediated DSB repair RAD52 RAD51 PCNA PMC7191165__F2 Classic UPR signaling pathways ATF4 EIF2A TRAF2 PMC7604572__F1 ATP drives ATPase pump, membrane potential and Hh patterning ECD SMO LPP HEL-S-162eP PMC11927159__F3 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer GPX4 STEAP3 HEL-S-64p TF GLS PMC3307887__F1 Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells LEP CD44 STAT3 PMC3668058__F6 Schematic representation of interacting fatty acid metabolic pathways in wild-type, D1, and D1o3-3 leaves DGAT1 PC LPA PMC11927159__F1 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer GPX4 SDC1 APAF1 BAX PMC5495058__F2 Signaling pathway in sea urchin sperm GC PMC4469332__F3 The production of BH4 within the DRG plays a critical role in pain signaling SPR PMC6785123__F5 Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma PIK3R1 NPHS1 NCK2 ACTN1 ACTN2 CASK NCK1 FYN WASL PIK3CA ACTN4 CD2AP PIK3R2 MAL PMC5399913__F1 Role of Srs2 in the promotion of PRR RAD51 RAD18 PCNA PMC4469332__F2 Intracellular levels of BH4 depend on three production conduits the de novo synthesis pathway, the recycling pathway and the salvage pathway CNTF SPR PTS NGF LIF DHFR IFNG PMC8043057__F1 Interactions of proteins encoded by studied genes in COVID-19 HEL-S-62p CS THBD ADAMTS13 FH PMC3493385__F2 RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways IGF1 PPM2C ADA PTEN SKI SGK1 NCR1 NCR2 PMC4553214__F2 IPA analysis based hnRNPD networks in oral cancer HNRNPAB HNRNPL MYL6 RPL13 MTOR ELAVL1 AGO1 PABPC1 TAF15 HNRNPD RPS2 TFG KHSRP SF1 ILF3 RTCB HNRNPF RPLP0 DKFZp434N041 HNRNPR RPS14 TIAL1 NCL YBX1 TRIM2 NONO SNRPD3 DDX3X RPL6 HNRNPA0 RPS16 FUS SMARCE1 SMARCC2 ARID1A AGO2 KHDRBS1 HNRNPC HNRNPH1 ATXN2 RBM14 RBMX RPS3 ELF4 CP PMC10379376__F5 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells TCF3 SOX2 WEE1 ASH1L EZH2 DNMT3B LATS2 SUZ12 PMC11608829__F6 miRNAs and circRNAs role in pathogenesis CEBPA PMC5611871__F1 AMPK-activating drugs that reduce cellular ATP levels, such as the antidiabetic metformin, promote tumor suppressive actions in a LKB1-dependent manner TSC2 TSC1 PTEN MTOR DEPTOR RHEB MLST8 PMC4946926__F10 The proposed model for production of IFNB in response to extracellular dsRNA TBK1 TRAF3 SRC TRAF6 IL6 TLR3 PMC5436728__F1 Deconstructing the Complexity of TGFB Signaling in Hematopoietic Stem Cells: Quiescence and Beyond SMAD2 TGFBR1 SMAD4 RHO TF PMC7303082__F6 Adenosine affects the B cell receptor pathway BTK SYK PLCG2 PMC4284624__F1 ITCH E3 ligase in ATM network ATM LATS1 JUN ITCH PMC8206147__F8 Schematic diagram of METTL14-mediated lncRNA OIP5-AS1 implicated in the Progression of PTC METTL14 EGFR ADAMTS8 PMC7084349__F1 Cellular mechanisms mediating activity-dependent translational control ELF2 EEF2K EEF2 MTOR PMC7084349__F2 Translational control in antidepressant action EEF2K EEF2 MTOR BDNF PMC3828572__F8 mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions PTEN MTOR PMC5610547__F5 Metabolic pathways MTAP BAD CS HP SMS PMC8106838__F4 Therapeutic toolkit to modulate Notch signalling RBPJ RIN1 ADAM17 PMC8106838__F2 Skin architecture and Notch pathway member distribution NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC8106838__F1 An overview of Notch maturation, activation and processing RBPJ SI ADAM17 PMC6541695__F2 IGF-2 bioactivity at the surface of an ovarian granulosa cell IGF2 IGFBP2 STC1 IRS1 IGF2R INSR PMC7545699__F7 Schematic diagram illustrating the role of repression of FGF signaling in inducing Dnmt3b inhibition during early development of IVF embryos FGF4 FGF2 SP1 DNMT3B PMC9388540__F6 Molecular model of FMRP-mediated regulation in GSCs GSK3B WNT5B PMC2647163__F3 Advances on the Understanding of the Origins of Synaptic Pathology in AD FYN GSK3B CDK5 ARC RAC1 BDNF INSR PMC5376330__F9 Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway VASP FPR2 RAC1 PMC8582326__F2 Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury RHO CLASP2 PMC10476430__F2 Underlying upstream and downstream mechanisms of cardiokines that mediate the heart-to-adipose tissue communication FGF21 PCSK9 FGFR1 FSTL1 LDLR MED13 MTOR PMC5577134__F3 Biosynthetic gene cluster and proposed biosynthetic pathway of ilamycins HEL-S-62p LIAS C6 PMC5244394__F9 Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation EGF ChAT EGFR PMC7022878__F10 Summary suggesting the mechanisms of LUT attenuated hepatotoxicity induced by PbAc IL16 KEAP1 GPX1 HEL-75 NOS2 PMC8457865__F8 WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M WNT16 OSM SHC1 OSMR STAT3 PMC2909029__F2 A possible mechanism for the inhibitory effect of p66Shc on mitogenic signaling EGF EGFR GRB2 PMC6135780__F1 Extracellular signalling roles of S1P MFSD2B SPNS2 ELL PMC7730311__F1 Immune interaction and metabolic character of tumor cells and the mechanism of immune checkpoint inhibitor and metabolic intervention SLC16A7 APC SIRT6 CD80 HIF1A HEL-S-133P PMC4681601__F1 Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy IDO1 KIT TLR4 SOCS3 TLR9 AHR APC MTOR IRF-1 FOXP3 PMC3131061__F1 TIR and NFKB signaling pathways EDAR BCR IRAK1 TRAF6 IRAK4 MYD88 TLR3 PMC5663846__F1 Kynurenine pathway HAAO AHR KMO PMC3638621__F11 The pathway map of urea cycle ARG2 OTC NAGS HEL-S-20 PMC11552425__F2 Whole-exome sequencing in cerebrovascular diseases ACVRL1 TMEM132B PDE4DIP NFX1 ACOT4 TPO EDIL3 TRPV3 MUC5B CHST14 NOTCH3 PLOD3 ADAM10 PMC9284488__F3 LPS-mediated atherosclerosis TLR4 MYD88 TNF TIRAP PMC11039815__F1 Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions TBK1 CGAS ABCC1 IRF3 SLC19A1 PMC6660578__F4 Genetic risk factors and synapse dysfunction in AD pathogenesis PSEN2 ABO PLCG2 CLU ADAMTS4 SORL1 PSEN1 BIN1 PTK2B ADAM10 FERMT2 PICALM CD2AP APOE PMC6125308__F2 c-Met/INSR crosstalk in hepatocytes HGF IRS1 INSR PMC2930673__F2 Transport of heme synthesis intermediates and heme in metazoans ABCB6 FECH SLC25A38 CPOX ABCG2 BACH1 PMC5257030__F8 Scheme of the interaction between the intrinsic apoptosis, autophagy and stress response pathways governing the HepG2 response to CdS QDs ATG3 APAF1 BCL2 DNAJB9 ATG14 BAX PMC4817777__F5 Regulatory pathway leading to colon cancer–promoting splicing aberrations HEL-S-30 PTBP1 MYC PMC8254267__F2 Gut microbiota-mediated immunomodulation in tumor COX2 CXCL16 LTA TLR4 PTGER4 MYD88 CXCR6 FOXP3 PMC2930673__F1 Cellular iron processing ABCB7 FES PCBP1 ABCB10 TF PMC7201932__F7 Graphical summaries BMP2 TGFB1 PMC8183409__F2 Mutations in PTEN and TSC1/2 are associated with dysregulation of translation and transcription TH TSC2 RYK RHEB PMC4019504__F5 Integrated Analysis of Genome-wide Copy Number Alterations and Gene Expression in MSS, CIMP-negative Colon Cancer NLK MDM2 CD44 APP SRC SFRP1 DKK1 MAP3K7IP1 WIF1 TCF4 PMC8997154__F2 Impact of Cannabinoid Compounds on Skin Cancer GPR55 TRIB3 BCL2 BAX PMC5131753__F2 Possible mechanisms of ribosomal proteins L5 and L11 signaling to MDM2 RPL11 MDM2 RPL5 PMC7477357__F1 Coagulation cascade and the fibrinolytic system TFPI PLG F2 APC TF PMC8152462__F4 Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs STAT1 MAX ATF2 MYC ATF1 TNF PMC2920636__F5 Molecular networks over-represented by E ANKRD1 RPL12 VEGFC PLAT PLAUR MRPL2 PLG THBS2 MYCBP MYC GRPEL1 PMC10297006__F2 Ezrin controls several major cellular functions through the regulation of downstream signaling transduction pathways RHO SIX1 SP1 PMC2266794__F4 Integrative Genome-Wide Expression Analysis Bears Evidence of Estrogen Receptor-Independent Transcription in Heregulin-Stimulated MCF-7 Cells NPAT NLK MOS DAO HEL-S-11 EGFR NEK2 PMC4617749__F4 Kyoto Encyclopaedia of Genes and Genomes (KEGG) annotated the Toll-Like Receptor Signalling Pathway as significantly enriched in the RNA-seq dataset for HC CD14 TLR5 CTSK TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 MAP3K7IP1 TLR3 STAT1 TLR8 TLR7 TLR4 LBP CD40 CD80 IL1B FADD TIRAP PMC4221383__F3 Developmental Pathways Activated in Melanocytes and Melanoma EDN1 EDNRB RAF1 PMC5583221__F1 Mechanism of axon degeneration and sites of action of chemotherapeutic drugs NMNAT1 NGF NMNAT2 SARM1 PMC9395689__F7 RAGE pathway activation and function in chronic kidney disease and COVID-19 HMGB1 PLG S100A8 APP LPA S100B PMC9395689__F5 RAGE pathway activation and function in chronic kidney disease and COVID-19 HMGB1 SMAD2 SIRT1 PMC9395689__F6 RAGE pathway activation and function in chronic kidney disease and COVID-19 HMGB1 CCL2 PMC8430758__F4 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease CD14 TLR4 LBP MYD88 TNF PMC9395689__F3 RAGE pathway activation and function in chronic kidney disease and COVID-19 NOTCH1 TRPC6 RAC1 PMC9395689__F4 RAGE pathway activation and function in chronic kidney disease and COVID-19 SMAD2 PMC4767650__F2 INHIBITOR OF APOPTOSIS PROTEINS AS INTRACELLULAR SIGNALING INTERMEDIATES BAX PMC8430758__F6 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease BAD MYC BCL2 EIF4E MTOR FADD PMC3983720__F8 Diagram of putative mDA differentiation pathway based on this and other studies TH LMX1A PITX3 SHH SMAD1 DKFZp781O1323 FOXA2 PMC12140325__F8 KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration through Regulation of Wnt/B‐catenin signaling Pathway LRP6 MKI67 AURKA KLF1 PMC8552907__F4 Enrichment analysis for specific cellular pathways CLTA AP2A1 AP2A2 NUP205 SEC23A EDEM3 FMR1 MAGOH THOC7 EIF3G THOC6 NUP93 AP2M1 GCS1 NUP54 RNPS1 LMAN1 CAPZA2 UBE2G2 GANAB RPN2 SNX6 HEL-S-107 NUP210 RPN1 HLA-C RAB10 HLA-A SMAP2 DDX39B ARPC2 ARPC3 HEL-S-269 NGLY1 CYFIP2 CLTC IGF2R CDC42 EIF2S1 EIF4A1 ARFGAP3 HSP90AB1 TFRC PRKCSH EIF2S3 RNF5 SEC23B RAB11FIP1 SEC31A HEL-68 SNX2 STAM2 EIF4A3 ZFYVE16 NUP155 SEC61A1 THOC2 RAB35 HEL-S-89n RRBP1 RAB4A RAB7A WASHC5 HEL117 AAAS HYOU1 PDCD6IP PABPC5 THOC1 HEL-S-125m THOC3 ARFGAP2 CANX NUP58 NUP42 DNAJB11 AP2S1 SSR1 STUB1 ALYREF DNAJA2 STT3B BAG2 RAB5C DDOST ACIN1 PMC5520455__F2 Schematic depiction of reported effects of mammalian caspases in autophagy-related effectors ATG16L1 ATG3 BCLAF1 DKFZp686F0183 PMC9656741__F3 PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer’s Disease LRRK2 CD33 PSEN2 SACS NOTCH3 SLC24A4 SORL1 FIG4 SETX SYT11 TMEM106B EPHA1 ATXN2 SPG11 PMC8170084__F1 Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease YTHDF2 YTHDF1 METTL14 ELF3 HNRNPC HNRNPA2B1 RBM15 WTAP VIRMA YTHDC1 PMC4641911__F3 Schematic representation of a hypothetical pathway in neurodegeneration involving stress signaling to and from the Golgi CDKN1B CDK5 LMTK2 PMC4585638__F3 ‘Obesity’ is healthy for cetaceans? Evidence from pervasive positive selection in genes related to triacylglycerol metabolism GNPAT PLCD4 DGAT2 ACACA MGLL MOGAT2 PLCG2 LPA HEL-S-104 ACSL6 ACSL5 GOT2 PC PLCE1 SREBF2 FABP2 PDE3B FABP6 PLCB4 PLCB2 GPAT2 MLXIPL CIDEA SERTAD2 PLCH1 CD36 PLCH2 PMC4711159__F2 Mechanisms regulating CD4+ and CD4+CD25+forkhead box protein 3 (FoxP3) balance APC IL2 CD40 CD80 CTLA4 FOXP3 PMC11899884__F4 PI3K/AKT/mTOR-mediated autophagy by NPs in cancer therapy TSC2 TSC1 RHEB PMC5500564__F3 Differential gene expression in the tamoxifen metabolism pathway CYP2C9 CYP3A4 PMC5500564__F4 Differential gene expression in xenobiotics metabolism pathway between Asian American and Caucasian American GNE NAGK DIO1 DUT PMC9027240__F2 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors KIF7 SUFU SMO PMC9027240__F3 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors LEP APC GSK3B LRP5 LRP6 PMC11899884__F1 PI3K/AKT/mTOR pathway in Cancer TSC2 TSC1 PTEN DEPTOR PMC5811448__F9 Model linking the adaptive and innate immune responses during tumour development via IL-33-ILC2 axis TH STAT1 CXCL10 IL33 CXCL9 PMC6278270__F1 The main molecular pathways linked to inflammatory and immunomodulatory activities modulated by Curcumin and Echinacea TLR4 MYD88 IL1B PMC3003336__F4 FLCN pathway TSC2 FLCN BAD TSC1 FNIP2 FNIP1 PTEN PMC6016849__F1 O-Linked Beta-N-acetylglucosamine (O-GlcNAc) Modification: A New Pathway to Decode Pathogenesis of Diabetic Retinopathy PGM3 OGA OGT HK2 PMC9317121__F9 BMP Signaling Pathway in Dentin Development and Diseases BMP2 SMAD2 SMAD6 BMP5 SMAD4 SMAD1 TF DKFZp781O1323 PMC8631517__F9 EMS1/DLL4-Notch Signaling Axis Augments Cell Cycle-Mediated Tumorigenesis and Progress in Human Adrenocortical Carcinoma DLL4 ESM1 CDC2 PMC5949932__F2 Regulating network of exosomal proteins and ncRNAs in tumors MYB ABL2 MMP9 S100A8 S100A9 JAM2 LAMC2 PMC4570614__F7 Dynamic differentially expressed (DE) genes were involved in T and B cell development as well as innate and adaptive immune response IL10 TH CDA IL13 FOS APC IL6 MYD88 IL12RB1 IFNG BASH LBP IL2 FADD PMC8781713__F6 LRG1: an emerging player in disease pathogenesis EGF RUNX1 ROCK1 SMAD2 EGFR SMAD4 ENG SMAD1 TF HMFT1766 DKFZp781O1323 STAT3 PMC5876636__F2 TGFB1 signaling via SMAD-dependent/independent pathways VCAN TGFB1 THY1 PLOD2 PMC7797639__F7 [missing figure legend] EGF JMJD8 EGFR PMC1193608__F8 Model of HAV interaction with the dsRNA-induced IRF-3 activation pathway TBK1 TANK IRF3 TLR3 PMC6375072__F1 Molecular signaling mechanisms of nicotine mediated anti-inflammatory effects HMGB1 STAT3 PMC4811984__F6 Reduced dopaminergic transmission in the mesolimbic pathway may overrule orexigenic signals from the arcuate nucleus TH POMC NPY AgRP ARC PMC8346982__F2 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment TGFBR1 HYAL2 CD44 HAS3 HAS2 PMC8346982__F3 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment CLU PMC5067692__F1 Newly synthesized FGFR1 can enter either the constitutive membrane pathway or regulated nuclear pathway in membrane pathway the receptor is processed and glycosylated in Golgi and accumulates in plasma membrane VIT NGF BMP7 PMC6689231__F2 Insulin signaling pathway IRS1 PDPK1 INSR PMC6158369__F1 Primary and acquired resistance to CD38 antibodies CD59 CD55 PMC8081604__F9 Polydatin Attenuates OGD/R-Induced Neuronal Injury and Spinal Cord Ischemia/Reperfusion Injury by Protecting Mitochondrial Function via Nrf2/ARE Signaling Pathway MAF KEAP1 NQO1 BAX PMC10341681__F6 Signaling pathways and targets of saponins against apoptosis in AD SOX8 BDNF TRAF2 PMC7229901__F1 Treg-mediated suppression AREG CD80 TIGIT PMC9249680__F2 Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives PC LPA GPD1 PMC4265676__F7 Schematic model of WRAP53B function in the DDR pathway RNF168 RNF8 ATM MDC1 RAD51 TUB H2AX BRCA1 PMC8133800__F1 Decorin as a possible strategy for the amelioration of COVID-19 SMAD2 SMAD4 PMC10341681__F2 Signaling pathways and targets of AB metabolism regulation by saponins TFEB APP ADAM10 AXL PMC10341681__F3 Signaling pathways and targets of saponin-regulated tau protein phosphorylation LCMT1 CDK5 IRS1 PMC8774728__F1 New Strategies and Combinations to Improve Outcomes in Immunotherapy in Metastatic Non-Small-Cell Lung Cancer CGAS CD80 TIGIT IFNG PMC10514522__F2 Microglial metabolism shifts from OXPHOX to glycolysis in the inflammatory state COX2 MYD88 CAD MTOR HEL107 PMC10341681__F4 Signaling pathways and targets of saponins against neuroinflammation in AD CDK2 NOX4 SOX8 PMC10514522__F3 Lipid metabolism in microglia in the inflammatory state NFKBIL1 LDLR APOE CD36 PMC10341681__F5 Signaling pathways and targets of saponins against oxidative stress in AD GCLC NOX4 HEL-S-22 PMC10254162__F11 FAK/Src signaling pathway SRC DOCK1 CRK CDC42 PMC8497485__F3 Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer STAT1 IRF8 MYD88 JAK1 MTOR ARG1 IL1B STAT3 PMC3582104__F1 The intracellular signaling pathways modulated by somatostatin receptors SST SRC BAX PMC4593735__F1 Innate immune interactions within the central nervous system modulate pathogenesis of viral infections RNASEL TBK1 NLRP3 CGAS IFIT2 EIF2A IRF3 MYD88 MAVS PMC7484982__F3 Reign in the membrane: How common lipids govern mitochondrial function PGS1 TAMM41 PRELID3B PRELID1 AGK CDS2 LPA STARD7 PSD PEMT CDS1 PC CEPT1 PGP CHPT1 PMC4996658__F2 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development RBPJ SMAD2 SMAD4 PMC7484982__F4 Reign in the membrane: How common lipids govern mitochondrial function MFF CERT1 DES BAX PMC5414836__F3 Cytokine Decoy and Scavenger Receptors as Key Regulators of Immunity and Inflammation IL33 IL1R1 PTEN MYD88 MTOR IL1B STAT3 PMC4996658__F3 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development SMAD2 SMAD1 PMC9230742__F6 Combined Transcriptomic and Proteomic Profiling to Unravel Osimertinib, CARP-1 Functional Mimetic (CFM 4.17) Formulation and Telmisartan Combo Treatment in NSCLC Tumor Xenografts SOX2 AGA EGFR OSM STAT3 BAX PMC4975441__F4 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells EPOR SOCS3 EPO PMC8555376__F1 Race to stymie BTK: zanu zings BTK CARD11 BCL10 BCR IRAK1 CXCR4 LYN SYK MYD88 CXCL12 MTOR STAT3 PMC11670978__F9 Pathway of action of HnAg in treating UC mice AHR TNF MUC2 PMC11048596__F4 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma PTPRC TLR7 BMP2 CD2 FSTL1 CER1 SPN RPSA RPS12 PMC11048596__F5 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma CTBP2 DKK3 MAFF ID4 BMP2 FSTL1 DDB2 RPSA RPL18A RPL19 E2F2 SLC2A3 TNFRSF1A MDM2 C6 FRAT1 RPS12 PMC4975441__F8 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells EPOR SOCS3 EPO PMC11711721__F7 Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/Beta-catenin pathway modulation APC GSK3B PMC11048596__F6 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma BMP2 APC MDM2 FSTL1 CER1 SMAD4 FRAT1 SMAD1 DKFZp781O1323 PMC7031145__F7 Phosphoinositide-3-kinase, phosphatase and tensin homolog, p38 mitogen-activated protein kinase and RAS pathways modulated by caffeine EGFR PTEN MTOR PMC2834246__F2 Regulation of chromatin structure by drugs of abuse NPY CDK5 FOSB HDAC5 BDNF PMC3391582__F2 Signaling Circuitries Controlling Stem Cell Fate: To Be or Not To Be TSC2 LRP5 LRP6 GPR49 MTOR LGR6 RHEB PMC2790539__F1 Apoptosis in cerebral ischemia and reperfusion BAD CAD BAX PMC3280275__F6 Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of TNFAlpha-Induced Nuclear Accumulation of the HIF-1A Transcription Factor in Cancer Cells ADCK2 TRIB2 HIF1A TRPM7 PMC7031145__F6 Inhibition of transforming growth factor B pathways caused by caffeine SMAD2 TGFBR1 TGFBR2 SMAD4 CTGF PMC5808116__F8 H. pylori T4SS induces potent IL-8 induction EGR1 HP EGFR PMC5029667__F7 PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells PIM1 DKFZp781B1423 MDM2 PMC11036351__F1 Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa GAL PMC3794591__F5 Pathway map of fatty acid metabolism SP4 PMC8165240__F1 Cannabinoid Signaling in Auditory Function and Development GDE1 COX2 ABHD4 F2 ABHD12 ABHD6 DAGLB DAGLA FAAH PTPN22 PMC5867015__F2 Signalling pathway of Pak1 in the heart PLN PAK1 FBXO32 RAC1 CDC42 PMC4405647__F13 Schematic presentation of molecular mechanisms by which acidosis controls the mTORC1 and eEF2K pathway to shut down protein synthesis and aid cancer cell survival TSC2 EEF2K TSC1 RHEB PMC9454586__F2 Oncostatin M: From Intracellular Signaling to Therapeutic Targets in Liver Cancer STAT1 SOCS3 JAK1 STAT3 PMC8349405__F3 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens SMOX SRM EIF5A PAOX DOHH DHPS SMS PMC3904630__F9 OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness CRX NRL NR2E3 RORB OTX2 NEUROD1 PMC8349405__F5 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens TBK1 STAT1 IRF9 IRF3 TYK2 MYD88 JAK1 MAVS PMC9475269__F2 Amino acid metabolism in skeletal cells ATF4 SLC7A7 PTH SLC1A3 SLC38A1 ASL GLS PMC9475269__F3 Amino acid metabolism in skeletal cells ACAN SOX9 GLS PMC10961392__F2 Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases CGAS MTMR3 CRH MTMR2 MTMR8 MTMR9 MTMR4 RYR2 MTMR6 MTM1 MTMR1 PMC4645172__F5 Glatiramer acetate treatment negatively regulates type I interferon signaling STAT1 LTA TLR4 ATF2 IRF3 MYD88 TNF TLR3 PMC6123652__F3 Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments FBXO18 FANCD2 PARP1 CHD4 MRE11A BRCA1 WRN POLD3 ZRANB3 RADX BRCA2 HLTF SMARCAL1 RAD52 RAD51 XRCC3 FANCB DNA2 RAD51C PMC3110186__F5 Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology IL10 RNASEL MYD88 REL TNF IL1B IFNG PMC2746238__F2 Induction of autoimmunity by pristane and other naturally-occurring hydrocarbons TBK1 TLR8 CCR2 TLR7 TLR4 TLR9 MYD88 TLR3 PMC5987909__F4 Stiffness-induced acute lung injury and pulmonary hypertension CTSK RHO PAH PMC3544185__F6 Complex Patterns of Altered MicroRNA Expression during the Adenoma-Adenocarcinoma Sequence for Microsatellite-Stable Colorectal Cancer ROCK2 ARHH HEL-S-11 APC PROC SKP1 SAA1 PMC6541445__F3 Cellular mechanisms and signals that coordinate plasma membrane repair RHO CDC42 PMC10819745__F3 Pattern diagram of immune cell response process triggered by PRR signal triggered by HSV-1 infection TBK1 CGAS TLR9 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 INF2 MAVS IFI16 MAL PMC7539815__F4 Proposed GnRH-analog effect on NAV3 and resultant effect on leiomyoma development NAV3 GNRHR PMC6585524__F1 Photic signaling pathways involving main kinases activities in the circadian clock CRY2 GC BDNF VIP PER2 PER1 PMC6610579__F3 Schematic summary of molecular pathways induced by HBx-B genes PAK1 CYP3A4 SULT2A1 IGF2 PAK6 opn ALOX12 SRC FOXO1 LAMC2 PMC5873314__F1 Theoretical model of how genetic polymorphisms influence symptom burden during breast cancer treatment NGF BDNF PMC7724080__F2 Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) PALB2 RIF1 SLFN11 SHLD3 SHLD2 SHLD1 PARG MRE11A BRCA1 ATM BRCA2 RAD50 ATR PMC4335352__F5 Example of non-mitotic functions of Plk1: effects on the mTOR pathway TSC2 ULK1 TSC1 BRAF EIF4E RPS6 EIF4B RHEB PMC5535966__F8 G-protein signaling of LW pigs BTK PC CSK ADRBK1 PMC8941195__F2 RAS/MAPK pathway ATF2 GRB2 JUNB PMC8941195__F3 a. PLCG signaling pathway and b. PI3K pathway PDPK1 PMC7956994__F1 Complement system with focus on most relevant targets for therapeutic inhibition HEL-S-62p CD59 C9 C4B_2 FH CRP C7 C5AR2 C6 C4A CR1 PTX3 PMC8027469__F2 Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer QK3 DKFZp781B1423 EGFR MDM2 SMAD4 RAF1 ITGB1 PCNA EIF3C PMC4258146__F2 Canonical Wnt/Beta-catenin signaling GSK3B LRP5 LRP6 DKK1 PMC12238443__F2 Current model of the BR signaling pathway in Arabidopsis thaliana BAK1 BIN2 ABCB1 PMC8431670__F3 UBL5/Hub1: An Atypical Ubiquitin-Like Protein with a Typical Role as a Stress-Responsive Regulator FANCD2 YAP1 PMC8036867__F2 Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1A) in the onset of Parkinson’s disease PINK1 GPX1 TFAM PMC7005498__F1 Cartoon Illustrating the UPR Pathway Involving Multiple Organelles and Three Branches, Several TFs, and Downstream Molecules Involved in Feedback Loops ATF4 EIF2A PMC11351691__F4 Hub proteins were obtained and verified by molecular docking NAMPT F10 BRAF HEL-S-30 P2RX7 EGFR PTGS1 CNR1 IDO1 CREBBP TLR4 AHR CYP2C9 KDR PIK3CA ABCG2 BRD4 PMC8139654__F11 Microfilaments and Microtubules Alternately Coordinate the Multistep Endosomal Trafficking of Classical Swine Fever Virus PAK1 LIMK1 ROCK1 EGFR ARHA RAC1 CDC42 PMC7725584__F2 Active compound-potential target network PIG59 F10 PRKCE CCNA2 PGR MAPK3 MAOA NOX4 ACHE MTOR FOSL2 CDK6 MMP2 F2 NCOA1 CHRM2 NOS2 JUN SELE FASN OPRM1 LYZ FOS PTGS2 IGF2 GFAP VEGFA NR3C2 IL6 RXRA CHRM4 AGER CISH RELA BIK BCL2 CSA2 SELP PPARG LCT PMC11049935__F5 Plant hormone signaling pathways and related DEGs BIN2 EBF2 TF PMC2993603__F1 A tincture of hepcidin cures all: the potential for hepcidin therapeutics TWSG1 BMP6 GDF15 LIF TMPRSS6 STAT3 PMC5076770__F2 The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care EGF COX2 HGF GSKIP APC SRC PTEN MTOR STAT3 PMC8683220__F2 Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. VCAM1 TNF PMC5471631__F8 RIPK1 and RIPK3 kinases engage the IFN-I pathway downstream of the adapter protein TRIF TBK1 RIPK1 TLR4 RIPK3 IRF3 MLKL PMC6610579__F5 The schematic image of HBx/AKT/FOXO1 signaling pathway and AA metabolism induced inflammation ALOX12 LTB PMC5683904__F7 Schematic to illustrate model of Wnt pathway GSK3B LRP5 CCND1 LRP6 DKK1 FOXJ1 PMC6851170__F9 The anti-TGEV effect of Lp-1s STAT1 ISG15 OASL IFNAR2 JAK1 IFNAR1 MX2 PMC3073855__F1 Childhood Obesity – 2010: Progress and Challenges POMC NPY CRH AgRP TRH PYY BDNF PMC2837985__F9 Proposed model for the regulatory mechanisms of the Ras and cAMP signaling pathways in stress response and antifungal drug susceptibility in C MND1 GSC2 PKP1 MSH6 CDC42 PMC7432085__F5 Pathway studio network analysis of PLA2R1 and PLA2R1 promoter methylation in breast cancer MYC ESRRA PMC9139316__F1 Detecting DNA: An Overview of DNA Recognition by Inflammasomes and Protection against Bacterial Respiratory Infections TBK1 NLRP3 CGAS RIPK3 IRF3 AIM2 IL1B ZBP1 CASP5 IFI16 GSDMD CASP4 PMC8113812__F3 Role of exosomes derived from serum in sepsis HMGB1 BAD MPO MYD88 IL4 TNF MTOR IL1B SOCS1 PMC8878749__SF2 Nanosized Codelivery System Based on Intracellular Stimuli-Triggered Dual-Drug Release for Multilevel Chemotherapy Amplification in Drug-Resistant Breast Cancer PTS CD44 PNP PMC8113812__F5 Role of exosomes derived from epithelial and endothelial cells in sepsis ROCK1 IRAK1 TRAF6 PTEN TNF IL1B PMC7560934__F1 Diagrammatic representation of Beta-cell function HNF4A GCK PMC8660205__F6 Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer MYB BAD CD37 PTEN tal-1 TSC2 PLN MDM2 CYC1 APP GAL RBL2 CD19 PMC5504167__F2 Corticotropin-releasing hormone (CRH) controls the placental “surveillance and response” system so that the fetus can detect threats to survival and adjust its developmental trajectory CRH NR3C1 PMC6456712__F1 MHtt aggregation, generation of ER stress and the consequent UPR protective and later pro-apoptotic responses KEAP1 ATF4 EIF2A PMC9700492__F5 Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper (Epinephelus coioides) IL10 EGR2 NFATC1 RELB SYK PLCG2 IL1B NFATC3 CALM1 PMC4738349__F10 Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis RIPK1 RIPK3 MLKL PMC4065342__F2 The biosynthesis pathway of the major terpenoids in plants ME2 MBP IPP PMC2291295__F1 Keratinocyte Apoptosis in Epidermal Development and Disease BAX PMC4001725__F2 Estrogenic Steroid Hormones in Lung Cancer EGF HRG IGF1 SRC MTOR PMC3299342__F3 Signaling by PERK, IRE1, and ATF6 ATF4 EIF2A TRAF2 XBP1 PMC9663996__F5 ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis NLRP3 HMGB1 MYD88 IL1B GSDMD PMC2291295__F2 Keratinocyte Apoptosis in Epidermal Development and Disease EGF BAD HGF NGF EGFR PMC12108044__F5 KEGG pathway enrichment analysis TNF PMC9528626__F2 OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases COX2 CXCR4 CD44 SRC IL8RB CD74 PMC7241622__F1 Intracellular signaling pathways examined (A) and the experimental protocol used (B) REST TG PMC12096500__F8 Proposed mechanism of PSVII treatment in psoriasis involves the modulation of the STAT3/NFKB signaling pathway and the regulation of pyroptosis NLRP3 IL18 GSDMD STAT3 PMC5322464__F3 MapMan overview of significant (FDR adjusted p ≤ 0.05 & log2 fold change ≥2) differentially expressed loci (SDEL) involved in biotic stress pathway, unique to PB1+Pi9, upon M MYB MSC ERF PMC4556464__F2 Hedgehog signalling pathway showing development of TNBC SMO PMC6279938__F1 Impact of i-proteasome subunits on innate immune signaling in myeloid cells TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 TLR7 TLR4 CCR7 CD40 CD80 IL1B PMC6398499__F4 Crosstalk between Wnt, RA and related signaling pathways in orofacial clefts CYP26B1 TBX1 ALDH1A3 FGF10 LRP6 PMC4584337__F2 Comparison between the biosynthesis of isoprenoids in photosynthetic organisms (A) and the biosynthesis pathway proposed in haloarchaea (B) CS IPP PMC10375653__F2 Involvement of the SIRT1-NLRP3 pathway in the inflammatory response NLRP3 TLR4 IL1B PMC2637651__F3 Transcriptomes in Healthy and Diseased Gingival Tissues CD14 NLK EGF MOS MAX STS FLNA BDNF CRKL PMC6400530__F2 Pathogen antioxidant networks: The examples of Mtb and T TH TXN2 APC MSRA PMC8899168__F7 4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway KEAP1 GCLC NQO1 PMC9072026__F1 Intertwined Relation between the Endoplasmic Reticulum and Mitochondria in Ischemic Stroke CASP12 ATF4 CASP9 BAX PMC10411465__F4 Alterations of polyunsaturated fatty acids metabolic pathways in AAD MMP2 VCAM1 MMP9 GLA PMC3161734__F3 Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii PDC AGK OTC ACD ARG1 NAGS MME RPE ASL ADK PMC10411465__F2 Gut microbiota-derived metabolites in AAD CUTA CUTC PMC12035886__F1 Mechanism of histone modifications in regulating enzalutamide sensitivity in advanced prostate cancer KDM7A DOT1L HOXB13 PMC10411465__F3 Major amino acid metabolic pathway involves AAD PRMT1 MMP2 ARG2 MMP9 ME3 SIRT1 PMC12035886__F2 Histone modifications drive neuroendocrine differentiation in prostate cancer EZH2 STAT3 PMC8170620__F2 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection NEK6 DRAM2 FOXO3A LNX1 STAT3 BAX PMC9191761__F1 Non-canonical WNT signalling pathways ARHA RYK ROR2 RAC1 ROR1 PMC8170620__F4 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection NOTCH2 PTEN EZH2 PMC11700300__F2 Pathogenetic mechanisms of WT1 in AML MYC CCND1 BCL2 WT1 TET2 PMC8170620__F1 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection SOCS3 TRAF6 BAG2 MYD88 STAT3 PMC8385445__F1 Leigh Syndrome: A Tale of Two Genomes SCO2 LRPPRC ZNF183 NDUFB8 NDUFS1 NDUFA12 TACO1 COX10 NDUFA9 SURF1 PET100 NUBPL TTC19 NDUFS8 SDHA NDUFAF6 UQCRQ NDUFAF4 NDUFS4 SDHAF1 NDUFV2 NDUFAF2 NDUFS3 COXFA4 NDUFA2 COX3 NDUFA10 NDUFAF5 PMC5021578__F2 Genetic Alterations of D-Catenin/NPRAP/Neurojungin (CTNND2): Functional Implications in Complex Human Diseases APC GSK3B RHO CDC42 PMC6398499__F1 Key components and potential pharmacological targets of Wnt signaling implicated in orofacial clefts LEF1 WNT9B GSK3B FZD2 TEF MSX1 LRP6 PORCN RYK ROR2 FZD1 WLS PMC6398499__F2 Crosstalk between Wnt, Cdh1, Bmp, TgfB and Fgf signaling pathways in orofacial clefts ACVR1 MSX1 BMP7 GRHL3 FGFR2 SPRY2 BMP4 Pax9 IRF6 FGFR1 SHH TGFBR3 TGFB1 PMC2966547__F1 Homocysteine metabolic pathways HEL-S-61p PMC9394413__F3 Normal and Pathological NRF2 Signalling in the Central Nervous System GCLM PALB2 KEAP1 GCLC FTH1 FTL GPX8 HMOX1 BRCA1 NQO1 BACH1 DPP3 BACH2 GPX2 HEL-75 BCL2 PMC6398499__F3 Crosstalk between Wnt, Shh, primary cilia and other related signaling components in orofacial clefts FOXF2 GLI3 KIF3A SHH FGF18 PMC7408991__F4 Redox homeostasis and metabolic shift through activation of the Nrf2-Keap1 pathway and regulation of the NAD+/NADH ratio by PM redox enzymes KEAP1 FOXO3A SIRT1 PMC6901795__F7 A schematic model of zbTRIM25-mediated RLR signaling pathway during RGNNV infection TBK1 TRAF3 TRAF6 RIGI IRF3 TRIM25 MAVS PMC3201744__F1 MiR-21, miR-126, and miR-148a directly or indirectly regulate DNMT1 in SLE CD4+ T cells.A TNLG8A EGFL7 TF PMC6770264__F1 Bone metastasis physiopathology: implication of cancer cell-microenvironment interactions and therapeutic targets CXCR4 CXCL12 BMP4 PMC6330604__F1 DSBR pathways and the effect of RAD51 paralog loss on pathway choice ATM BRCA2 MDC1 RAD51 MRE11A PMC8405392__F4 Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology NR3A2 MAPK8 PTGS2 MMP9 ALB ALOX5 ADRB2 PTEN TNF PTPN22 MMP3 PTPRC RARA NFKBIA HEL111 RELA IL2 ELANE PMC2975945__F4 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS LTA NFIB LCK RELB CD40 REL MAP3K7IP1 LTBR TIRAP PMC6710350__F4 Microglial inflammatory responses by IFNB signaling STAT1 COX2 SOCS3 STAT2 IRF9 TYK2 IFNAR2 MTOR IFNAR1 SOCS1 IFNG STAT3 PMC9394413__F2 Normal and Pathological NRF2 Signalling in the Central Nervous System KEAP1 RBX1 PMC3763042__F1 Working model of renoprotective pathways activated by relaxin SMAD2 NOS2 PMC2975945__F2 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS PIM1 TIMP1 TF PMC5330146__F2 The SOLLI model predicts targets of therapy CCR2 SCD NR1C1 PMC8232256__F4 Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma TH CCR2 CXCL2 CCL2 PMC4402485__F1 Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors TLR8 TLR5 TLR7 TLR4 TLR9 IRF3 HEL-S-92n MYD88 TLR1 TLR3 PMC5283711__F1 Redifferentiating Thyroid Cancer: Selumetinib-enhanced Radioiodine Uptake in Thyroid Cancer RET NRAS GRB2 PTEN MTOR PMC3491909__F1 Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR TSC2 RICTOR PI3 TSC1 PDK2 PTEN MTOR DEPTOR SGK1 RHEB MLST8 PMC5036404__F2 Schematic overview of the molecular pathways involved in necroptosis TRADD CYLD TNF TRAF2 FADD TLR3 MLKL PMC9082937__F7 Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis TLR4 SOCS3 AXL PMC11232677__F7 KEGG pathway analysis of differentially expressed genes on cell cycle pathway in AML patient group with high beta-catenin levels vs controls PLK1 TTK WAPAL SMAD4 DBF4 MAD1L1 CDK7 MTBP DDX11 CCNB1 MIA CDC27 NIPBL RAD21 PTTG1 TICRR MAU2 CDC14B CD82 CDC25B CDC45 CDC20 CDC6 CDK2 CCNB2 CD7 PCNA SKP2 TRIP13 PMC11232677__F8 KEGG pathway analysis of differentially expressed genes on signaling pathways regulating pluripotency of stem cells in AML patient group with low beta-catenin levels vs controls FZD3 TCF3 SOX2 RIF1 SKIL NODAL DUSP9 LIF TBX3 APC SMAD4 PIK3R3 BMP4 BMPR2 IGF1 REST JAK1 DKFZp781O1323 STAT3 PMC3847898__F1 Wnt signaling pathways and the effects in mature synapses APC LRP5 LRP6 ARHA RAC1 PMC2627520__F2 Biosynthesis of Natural and Hyperelongated Chondroitin Sulfate Glycosaminoglycans: New Insights into an Elusive Process CS CHSY3 CHPF CHSY1 PMC187486__F8 Effects of Cdk4 disruption on the pathways controlling senescence and transformation CDK2 MDM2 CDK4 PMC5731654__F2 Impact of BRAFi on T cell response to melanomas BRAF TYRP1 PMC3742913__F5 Gene pathways revealed by comprehensive genomic profiling CCR5 CCR2 SOCS3 PLK1 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 CCR1 IL16 MMP2 APAF1 CCR7 CASP9 SRC HEL-S-44 SP1 PREX1 IRF-1 CASP8 RUNX3 c-fgr BMP1 STAT2 VAV1 CXCL10 TNF HRAS MMP14 CXCR4 CXCL12 CASP4 CXCL1 CCR3 TRADD RUNX2 IL9 TGFBR1 TGFBR2 CASP2 CXCL16 TLR4 CXCL17 IL2 CXCL6 CDK4 IL4 IRF4 EGR1 RUNX1 FOXO3A IFNE LIF CCR4 CD44 IL24 PARP1 MMP16 IL6 ITGB1 CASP3 CXCR3 MMP12 AK3 LCK FHL2 JAK3 SYK JAK1 TRAF2 OSM FADD SMAD1 DKFZp781O1323 SOCS1 NCF2 STAT3 PMC3319919__F2 Components of the TLR pathway and genes commonly induced during the innate immune response of zebrafish to bacterial infection TBK1 MYB HEL-S-62p EBP IRAK1 MYC TRAF6 IRAK4 MYD88 HEL-S-78p CASP9 IL1B MAL IL10 FGA CFB MMP9 MAP3K7IP1 SLC30A1 BIRC2 F5 C6 NCF1 IRAK3 TAB3 PMC3824029__F1 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease ITK BTK BCR ATF2 LYN GRB2 SYK CD80 LAT GATA4 PMC5528934__F2 Genes associated with paclitaxel (A) and gemcitabine (B) mechanism of action (direct targets, metabolizing enzymes), genes previously associated with resistance, and stable genes in the biological pathways targets HEL-S-62p CDA BAD MAP2 BIRC5 BCL2L1 ABCB11 BMF CMPK1 GBP1 MAP4 RRM1 RRM2 ABCB1 BAX CSAG2 ABCC10 FGF2 TMEM243 TUBB1 CNGA3 DCTD HEL74 SLC29A1 SLC28A3 RRM2B TUBB4B NFKB2 TWIST1 ABCC1 TYMS BCL2 OPRK1 TUBB4A AK1 BCAP29 PMC4342515__F1 ncRNAs affect Akt pathway in cell cycle SP2 RAB40C CDK6 CCND2 ING4 ATM ERBB2 CDK2 NRP1 MDM2 RBP2 CDK4 SP1 PMC3137149__F1 Simplified model of the tuberous sclerosis complex signaling pathway TSC2 TSC1 MTOR DEPTOR RHEB PMC4435677__F2 Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma HGF DCLK1 YAP1 VEGFA IL6 RB1 CDKN2A MTTP COX2 TLR4 IGF2BP3 CDKN1A TP73 MAVS PMC4342515__F2 ncRNAs affect CDKIs and Myc pathway in cell cycle MXD1 IGF2BP1 CDK2 CCND1 CDK4 EIF4E MTOR DNMT3B CDK6 CCND2 PMC9225019__F1 Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup MAF FGFR3 CCND1 CCND3 CCND2 PMC5872179__F2 Proximal T-cell signaling cascade FOS LCK VAV1 ZAP70 MYC PYY REL JUN PMC5036404__F1 Schematic overview of the intrinsic and extrinsic arms of apoptotic signaling BAD TRADD CYLD BCL2 TNF TRAF2 FADD OPA1 BAX PMC12060353__F8 Aseptic inflammation caused by acinar cell injury leads to local tissue hypoxia CXCL1 IL8RB COL1A1 PMC8489222__F2 Targeting smooth muscle cell phenotypic switching in vascular disease MYOCD GATA6 IRS1 TET2 PMC8885929__F4 GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson’s disease DAO HEL-S-11 ACHE PMC137498__F6 Regulation of Cdc25A by Chk1 CDK2 PMC3042531__F3 Regulation of Innate Immunity by signaling pathways emerging from the endoplasmic reticulum TLR4 ATF4 IL6 MYD88 TNF XBP1 TIRAP PMC8489222__F4 Targeting smooth muscle cell phenotypic switching in vascular disease CCND1 LATS1 RHO LATS2 CCND2 PMC3855094__F7 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects ITK FGFR1 BRAF WEE1 ALK CDK2 LCK EGFR SRC CDK4 CDC2 STAT3 PMC12176010__F1 Research progress on the regulation of autophagy in cardiovascular diseases by chemokines TSC2 ULK1 TSC1 ULK2 DEPTOR RHEB MLST8 PMC3938021__F3 Dissecting the Molecular Basis of the Role of the O-Mannosylation Pathway in Disease: Alpha-Dystroglycan and Forms of Muscular Dystrophy B4GALT2 B3GALNT2 PMC3524152__F2 Bacterial effector targets the TRAF6-NFKB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells BCL10 TRAF6 MAP3K7IP1 PMC2757135__F1 Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states NPC1 CYP11A1 NPC2 PBR STAR PMC3855094__F5 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects ITK FGFR1 BRAF WEE1 ALK CDK2 LCK EGFR SRC CDK4 CDC2 STAT3 PMC8194945__F1 Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway MAF KEAP1 RBX1 IL1B PMC9146859__F2 Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals CH25H ZMPSTE24 SCARB1 NR3A2 APOA5 LDLR ABCA1 MED1 HMGCR PMC4395516__F7 Reported interactions between factors associated with Peters anomaly FOXC1 CYP1B1 SLC4A11 PITX3 FLNA PITX2 FOXE3 HCCS TFAP2A B3GLCT NDP PMC7177266__F4 Speculated view of the melanin synthesis pathway SLC24A4 ASIP BCL2 MC1R SOX10 PMC5772929__F1 Mechanism through which metformin exerts its antitumor effects (A) by reducing the level of insulin in serum to inhibit the PI3K/Akt/mTOR signaling pathway and (B) by activating AMPK to inhibit the mTOR pathway TSC2 BAD TSC1 CCND1 MTOR RHEB PMC6753625__F1 Common signaling pathway for IL-1 family cytokines IL36A IL33 TRAF6 IL1R1 PMC8250151__F1 Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19 CCR2 CCL7 CCL2 MTOR ARG1 PMC3250228__F3 FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES DHFR CYP2E1 PMC8584156__F3 Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity IPP PMC3613936__F2 Striking the target in iron overload disorders BMP6 TMPRSS6 PMC3196888__F8 A model showing the overlapping functions of MMR and FA proteins in ICL and MMR MSH3 MSH2 ATR PMS2 PMC7967251__F4 Potential signaling interactions between LPA and p53 in transformed cells KLF5 MDM2 LPA ACP6 PMC7967251__F2 Crosstalk between the p53 and sphingolipid pathways.The complex interplay of p53 with key enzymes of the sphingolipid metabolic pathway in modulating DDR is shown above ATM CERS5 SPHK1 ATR CERS6 PMC4055201__F8 Schematic diagram illustrating the possible mechanisms responsible for CORM-2 effects on LPS-induced VCAM-1 expression in RASFs VCAM1 FOS TRAF6 MYD88 JUN PMC7013392__F4 Representation of the targets of stemazole (ST) involved in the MAPK signaling pathway NF1 CD14 NLK MAX TRADD JUND ECSIT TRAF2 PMC10413047__F2 LncRNAs regulating the proliferation and apoptosis of NSCLC DKFZp781B1423 YBX1 RING1 PMC10413047__F3 CASC9 and lncRNA UCA1 in drug resistance in NSCLC EZH2 FOSL2 PMC4138268__F8 Schematic representation of smoke-provoked MUC1 glycosylation in regulation of MUC1-C/p120ctn interaction and adherens junction (AJ) disruption EGFR GALNT6 SRC PMC5323396__F1 TLR molecular cascade NLK GSK3B MYD88 PMC5323396__F2 General overview of the Wnt signaling pathway APC LRP5 LRP6 ARHA PMC5323396__F3 Proposed molecular talking points between TLRs, Wnt, and nuclear factorKB (NFKB) NLK RELA GSK3B LRP5 PIAS1 LRP6 RAC1 MYD88 REL PMC3166557__F2 Planar Cell Polarity Pathway – Coordinating morphogenetic cell behaviors with embryonic polarity DAAM1 APC WNT1 PTK7 ROR2 RHO PMC2998095__F7 ID2 in clock resetting GIG8 PMC2877959__F3 Uric acid transport and disease MAP4 ABCG2 PMC4590647__F7 rLGALS9 internalization and signaling in CRC MAP2K1 RAF1 DKFZp686F0183 PMC8172013__F1 Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling APC NOTUM GSK3B LRP5 LRP6 SFRP1 DKK1 PMC7987655__F1 Tourette Syndrome Risk Genes Regulate Mitochondrial Dynamics, Structure, and Function SHANK3 CBLN2 PMC9496903__F7 ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism SIRT1 PMC5731985__F2 Mesenchymal stem cells in idiopathic pulmonary fibrosis CXCR4 MSC CXCL8 PMC8059835__F8 Hippo signaling pathway in podocytes after GSK3B knockdown NF2 SMAD2 AJUBA LATS1 RASSF6 FAT4 PMC7462725__F2 Pathophysiological processes that drive cyst formation and growth in renal tubular epithelial cells of the collecting duct in ADPKD and the mechanism of action of vasopressin V2 receptor antagonists and SST analogues TSC2 TSC1 MTOR CFTR PMC3047474__F1 Architecture of intestinal TD and TI IgA responses CD40 PIGR TSLP PMC3047474__F2 Innate IgA-inducing signaling pathways RUNX3 IRAK1 AID TRAF6 IRAK4 MYD88 TRAF2 PMC11931165__F8 Osteogenic differentiation of GLP-1RA on BMSCs RUNX2 APC LRP5 SP7 PMC11036006__F4 Diagram of “component-target-pathway” HTR6 PDE4D CASP6 HTR1B PDE5A ROCK1 EGFR NOX4 CASP2 DRD1 ACHE DRD2 TRPV1 PRKCA KDR MMP2 HEL-S-11 APP IL2 XDH ELANE CDC2 ABCB1 CASP8 RORC ADRA2C PTGS2 FGF2 VEGFA AKR1B1 CA9 TNF HPSE EDNRA MMP12 HTR2A ADRA2B HTR2B STAT3 PMC6177612__F3 Metabolic pathways of arachidonic acid COX1 PMC9290242__F3 Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management MTHFD1 HEL-S-51e DHODH MTHFD2 GLS PMC8515898__F1 Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer NLRP3 GSDMD PMC3118759__F5 Alteration to activity of the Akt/GSK3B signalling pathway can explain a number of the changes observed in microarray analysis of flies expressing rCAG, rCUG and rAUUCU repeats in the nervous system ATXN1 NGF ATXN3 HTT GSK3B BDNF PMC4615895__F6 The model for effect of miR-214 on osteoclastogenesis PDK2 PTEN PMC3353888__F1 Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis TH GNA11 POMC ADRA1B PNMT DDC DBH ADRA1A PMC4139891__F1 In renal cancer cells, stem cell factor (SCF) binding to the c-Kit receptor (c-KitR) induces several signal transduction pathways that lead to its proliferation, invasion, survival, and angiogenesis FYN LYN SHE PTEN NEDD8 RAC1 MTOR OTP STAT3 PMC4214862__F1 PI3K/AKT/mT0R signaling pathway TSC2 RICTOR BAD TSC1 ELF3 MDM2 CCND1 PTEN EIF4E MTOR PMC5436942__F4 A) IPA analysis suggests the involvement of signaling by ITAMs (immunoreceptor tyrosine-based activation motifs) in the FcGR pathway at 24h c-fgr PXN ACTR2 PIK3R2 PMC6283278__F1 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing MFN1 PINK1 MFN2 NRF1 NFE2L2 TFAM FIS1 OPA1 PMC3397862__F7 Schematic representation for the up-regulating mechanism of NSC proliferation by modulating Notch signaling with Lewis X-containing glycans in NSCs HES5 NUMB NOTCH1 FUT9 PMC6283278__F2 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing TBK1 MFN1 CGAS NRF1 TLR9 FOXO3A NFE2L2 FOXO1 PINK1 MFN2 F3 MEN1 SIRT1 TFAM FIS1 TF OPA1 PMC5489563__F1 Action of thioester-containing proteins (TEPs) in mammals and mosquitoes HEL-S-62p VTN TEP1 C1S PMC6283278__F3 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing ULK1 TFEB IGF1 RHEB PMC9032523__F1 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? NAPRT AOX1 NAMPT HEL-S-90n KYNU KMO NNMT NRK PMC6545170__F2 Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC9032523__F3 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? HEL-S-61p AOX1 NAMPT NMNAT1 NMNAT2 NNMT NMNAT3 PMC2999349__F3 Location of 2,4DNT impacted genes in the pathway association network PPP2R2B PTPRG PLCB1 PMC6695471__F1 Transcriptional regulation of carotenoid biosynthesis pathway (CBP) genes in photosynthetic tissues DET1 DDB1 RFWD2 PIF1 PMC2790753__F1 Microarray data for the genes in the pathway coined from the central genes in the KEGG pathways ‘insulin signaling pathway’ and ‘adipocytokine signaling pathway’ IKBKG SOCS3 TRADD PCK1 FACL4 CPT2 RXRB EXOC7 FLOT1 ACSL5 ACSL1 LEPR PRKAG1 PFKP FASN ADIPOR1 ADIPOR2 PFKL TNF FOXO1 CBL RXRA FLOT2 IKBKB NFKBIA LEP NFKBIB TNFRSF1B SLC2A4 CPT1A RELA TNFRSF1A PGC PRKAG2 JAK1 TRAF2 PPARG ADRB3 CD36 STAT3 PMC2724975__F6 Illustrating expansion results with ambiguity networks ME1 SKA1 SELL PMC3759924__F2 Lin28/let-7 regulatory axis HMGA2 RICTOR DGCR8 MSI1 TUT4 DROSHA CCND1 CDK4 CCND3 TUT7 INSR PMC9031400__F3 Tumor Microenvironment in Glioma Invasion GDNF IL6 STAT3 PMC11085166__F2 Keap1-Nrf2 signalling pathway for gene expression control MPO KEAP1 PON1 NQO1 PMC5061804__F1 Cellular signalling upstream and downstream of mammalian target of rapamycin (mTOR) complexes ULK1 IGF1R FOXO3A GSK3B PTEN ATG101 MTOR DEPTOR FOXO1 RHEB TSC2 TSC1 F3 RPS6 EIF4B PMC8526643__F2 What signals the glyoxalase pathway in plants? ME1 HEL70 PMC4143103__F2 Canonical and noncanonical TGFB signaling SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA SKI PMC3372091__F3 Mechanisms underlying the biological effects of polyphenols IL16 KEAP1 BDNF PMC7365993__F2 RAS-RAF pathway in relation to miR-31 and RASA1 FOS EGFR GRB2 PMC6493850__F2 Putative mechanisms underlying the neuroprotective effects of TGF‐B1 against AB‐induced neurodegeneration GSK3B LRP5 LRP6 DKK1 PMC2679364__F6 OVARIAN CANCER BRAF PMC12249743__F5 Representation of epidermal human cell infection by SARS-CoV-2 and antiviral mechanisms TBK1 CGAS STAT2 PMC6262606__F1 Nuclear factor-kappa B signaling pathway BCR RELA RELB CD40 LTBR PMC3474261__F1 MTORC1 signaling and genetic mutations at specific sites in the pathway TSC2 TSC1 SOX2 EIF4E MTOR RHEB PMC4890987__F14 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells MAPKAPK2 GIG8 TLR9 MAX FOS TAOK3 RPS6KA5 TRAF6 MYD88 MAP2K3 DDIT3 PMC3403683__F1 T cell receptor (TCR)-mediated signalling pathway FYN APC LCK ZAP70 PALM LAT PMC5905132__F2 Adversarial functional module (AFM) pairs CLTB AP2A1 AP2S1 RTKN AP2M1 RHPN2 RHO TAX1BP3 CBL PMC4890987__F13 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells LEF1 LRRFIP2 ATF4 PKIA CTCF CCR7 SMAD4 PMC6352437__F8 Schematic diagram on the molecular mechanism of the anti-adipogenic effect of 10-HDA in 3 T3-L1 preadipocytes EBP LPL TG HEL-S-104 PMC4890987__F10 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells G0S2 FOS BTG3 ZNF274 CDK4 FLNB MAP2K3 JUN CRKL PMC11790572__F1 Shared immunopathologic mechanisms of the atopic march IL33 IL25 TSLP TGFB1 PMC3218055__F3 Proteomic Signatures of Human Oral Epithelial Cells in HIV-Infected Subjects LIMA1 SNCG CRABP2 DNAJC7 HEL-S-34 AHSG HEL-S-99n EZR HEL113 DKFZp761E1322 PMC7921839__F2 Diagram depicting the main proposed events in the autophagy pathway ATG10 ATR ATG14 DKFZp686F0183 PMC11740111__F5 Analysis of the effects of TPBG-KD on signaling pathways using KEGG BAMBI INVS RNF43 CBY1 APC ALB SOST NOTUM SHE RYK RBX1 NLK MCC SIAH1 DOCK2 PMC11383167__F1 Biomarker validation in AGS STAT1 ISG15 SIGLEC1 RSAD2 STAT2 IRF9 IFI27 PMC9688631__F3 Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia ATM CDK2 MDM2 CDK4 ATR CDK6 PMC5341791__F3 Signaling pathways triggered by GDNF activation of the RET transmembrane receptor RET BCL6B FOS GRB2 GDNF SRC ETV5 PMC3380091__F3 Endometrial androgen target gene set BAD TRH MAOA SHCBP1 HIF1A CCKBR PMC7322088__F7 Enhancing tumor growth due to the Hippo pathway being interrupted by LATS2 O-GlcNAcylation NF2 OGT LATS2 PMC6242950__F3 Caspase-dependent apoptosis pathways in myofibroblasts BAD BCL2 SMPD1 RHO PTEN FADD BAX PMC3654583__F1 The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis CXCL10 IRF-1 MAVS PMC3113675__F7 Arginine methylation of G3BP1 regulates both Ctnnb1 mRNA and canonical Wnt/Beta-catenin signaling PRMT1 WNT3A DVL3 PMC4214635__F2 De Novo Mutations in Moderate or Severe Intellectual Disability DYNC1H1 FLNA KIF1A SHANK3 VPS4A MYH10 RYR2 SYNGAP1 CACNA1A SMC1A SCN2A ARD1A GRIN1 WDR33 PDHA1 SPTAN1 TRIO SETBP1 EGR1 SET ALG13 DDX3X CAMK2G STAG1 PPP2R2B TUBA1A KCNQ2 NACC1 HEL-S-80p CACNG2 CDKL5 BCORL1 GRIN2B YY1 ASH1L KCNQ3 PPP2R5D TCF4 PMC9133251__F6 Modified natriuretic peptides and their potential roles in cancer treatment SI GC CNP PMC7755097__F3 Retinoic acid signaling pathway is identified by topographic transcriptomic analysis of NAcSh GAD2 CEBPE MAPK8 HEL-S-1 P2RX7 CD6 SIAT4C PDYN HES1 MMP7 GRM2 HEL-S-44 CFP CSNK1A1 BTG2 COL2A1 WNT7B REC8 UBE3A CRABP2 ABI3BP RXRA PTPRU SETD5 GRB2 NR1C2 JCHAIN CAPN7 PPP2R5B DDX10 PRKCH TERF1 MEF2C SLC25A15 PTP4A3 HOXB6 LYPD1 CREG1 HSF4 KIF1B HIVEP3 UBE2D3 TSPAN14 FUBP3 KANSL3 SHKBP1 LTC4S NME2 MAP2K3 XBP1 PRNP RARA ISG15 CYP26B1 NR1B3 CRABP1 SYN1 FABP5 DPPA3 NAV2 NEUROD6 CHL1 YBX1 PPM1G TBX2 CD34 PHLDA1 MGST3 NFATC3 GATA2 LAMB1 ASNS MCL1 SLC26A3 RPL5 COL4A2 PMC6947386__F2 Cellular calcium [Ca2+] homeostasis and signaling: Organelles and molecules that are involved in Ca2+ pathways TRPC5 TRPC3 MCU ORAI1 STIM1 PMC4997072__F2 TLR signal transduction pathways TBK1 CD14 TLR4 TRAF3 LBP TRAF6 IRF3 MYD88 TLR3 TIRAP PMC4406223__F4 Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation RS1 CTRL IRS1 PMC8800007__F3 Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair NAT10 PARP1 MORC2 SIRT1 BAX PMC8421919__F2 Bioinformatical identification of key genes regulated by IGF2BP2-mediated RNA N6-methyladenosine and prediction of prognosis in hepatocellular carcinoma CDCA5 GGH CCNA2 SOCS3 SPON2 FOXM1 CHAF1A SPC24 MAPK3 CSTB EMC3 CDCA3 NHP2 GINS2 HMGB2 MGAM TUBB IGF2 TACC3 MCM7 HCTP4 HRAS HMGA1 MCM3 HSPG2 HJURP HEL-S-93 PMC6876670__F2 Canonical WNT/Beta-catenin pathway: “on” and “off” states APC GSK3B LRP5 CCND1 LRP6 DKK1 PMC6876670__F3 WNT/Beta-catenin, TGFB1, PI3K-AKT, SMAD, and PPARG pathways APC LRP5 CCND1 LRP6 PTEN DKK1 PMC7878545__F6 Summary of Treg-of-B (P) cell generation and their molecular mechanisms in alleviation of asthmatic inflammation AHR LAG3 BAX PMC7476662__F4 Predicted genes in the MAPK signaling pathway targeted by downregulated serum miRNAs (miRNAs) in BD, sarcoidosis, and VKH PPP5C BRAF ATF2 TGFBR1 RRAS FGF13 CACNB4 FGF14 MEF2C TAOK1 PMC2953449__F3 Different effects of gut- and brain-derived serotonin on the osteoblast HTR1B ATF4 ADRB2 PMC6876670__F6 Canonical WNT/Beta-catenin pathway, Warburg glycolysis, and cancer APC GSK3B LRP5 LRP6 PTEN DKK1 HEL-S-133P PMC3061549__F1 The classical and alternative selection pathways in the thymus CD8A FOXP3 PMC3175541__F7 NK2 homeobox 1 (NKX2-1)–Sam Pointed Domain Ets-like Factor (SPDEF)–associated gene network analyzed using Ingenuity Pathway Analysis AREG ITGA7 TLN1 SPDEF HEL-S-116 CCKAR ORM1 IFNG CREBBP SCIN MMP12 NKX2-1 ORM2 CLCA1 ICOS PMC8950345__F1 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy PALB2 GIG8 FANCD2 BRCA2 FAAP24 FANCM PARP1 MRE11A FANCE PMC8950345__F2 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy FANCD2 MSH6 RAD51 FANCM MSH2 RAD51C PMS2 PMC5851908__F1 Regulatory network for p42.3 involvement in tumor cell apoptosis (red pathway indicates the maximally possible acting pathway) PAK1 BAD ROCK1 S100A2 S100A4 TRAF2 S100B HEL-S-43 BAX PMC4196247__F6 Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC3832246__F1 TNFR1 signaling of cell survival/proinflammatory and apoptosis pathways. Upon TNF receptor activation, complexes I (survival pathway) and II (apoptosis) are formed MMP3 TRADD TRAF5 VCAM1 CXCL10 SHARPIN TRAF6 TNF TNFAIP3 TRAF2 FADD PMC5851908__F3 Regulatory network for p42.3 involvement in colorectal cancer cell apoptosis (the red pathway indicates the possible acting pathway for p42.3 involvement in cell apoptosis) CASP3 BAD APC MDM2 CASP9 PTEN DCC WWOX BAX PMC3073571__F8 Cone-specific Visual Cycle LRAT RPE65 RPE PMC6950849__F1 Central role of TORC1 signalling pathway and importance of wild alleles for yeast nitrogen consumption GEN1 EIF2A GIN1 PMC2916406__F7 New model for a novel role of p38 MAPK in the DNA damage response in cancer cells ATM CDC2 ATR PMC6053314__F5 NFKB Activation in primary CNS lymphoma IRAK1 PIM2 CXCR5 TRAF6 MYD88 MTOR RGS13 CD79B CD79A CXCL13 BTK PIM1 CARD11 BCL2A1 BCL10 BCR BCL2 SYK JAK1 IRF4 STAT3 PMC6943912__F1 Immunogenetic effects of low dose (CEM43 30) magnetic nanoparticle hyperthermia and radiation in melanoma cells CCR2 CCR3 CCR6 CCL21 CCL7 CCL2 CXCR6 CCL16 CXCL16 CCL14 CCL24 CCL13 CCR7 CXCL17 CCL19 CCL25 CCL11 CCR4 CCL4 CXCR3 CXCR4 CCL23 CCL22 CCL3 XCL2 PMC12132251__F4 Functional integrative gene-based enrichment for genes annotated to the meta-analyzed hypo- and hyper-methylated CpGs consistent across all three studies and across all LF phenotypes: GACRS, CAMP and VDAART MYADM PC MPO BAGE CAPN12 ZFP2 KRT14 TTC21A PMC6024579__F2 Hepatic cell death pathway and liver injury in response to high fat diet exposure CASP3 TNF CASP8 IL1B FADD PMC5930509__F9 Proposed hypothetical model depicting the involvement of miR-424/503 cluster in the Activin signalling pathway by targeting SMAD7 SMAD2 SMAD4 PMC9701047__F6 Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice CS HEL-S-162eP PMC2655379__F8 Potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle PDC IGF1 PDK4 IRS1 PMC10221877__F8 Response of DA metabolic pathway to Cd stress in duckweed TH PNMT DBH PMC6745137__F6 Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis CSNK1D HGS DVL2 PRKAR1B SKI MEA1 CENPB DUSP4 OPRD1 FOS TNF POFUT2 DPF2 THPO EIF4G1 SMG5 FBXL19 CYP2C9 SRXN1 SMN1 IGF2R IFNA1 TFDP2 LNX1 USP30 HSF1 DPP9 FCN2 MBD3 ARHGAP1 SEC24C KIF13B CYTH2 BRPF1 STS LDLR OCRL IL1B JUN FASN PLK3 PHF5A RXRG QSCN6 RNF4 PBX1 RELA CCL18 VAMP8 INHBA CCL3 PMC7078051__F4 Iron homeostasis disruption in HLRCC KEAP1 FOXM1 FTH1 VHL FTL RBX1 PMC4049860__F3 CCM1 and the second life of proteins in adhesion complexes APC LRP5 LRP6 PMC3973244__F7 Role of RNase L and TLR3 activation during inflammation in insulin response of obese people's myotubes RNASEL TLR4 SOCS3 IRF3 MYD88 IRS1 TLR3 PMC7815887__F2 T2 inflammatory pathway (eosinophilic COPD and asthma) and the target sites for anti-IL-5 agents IL5RA IL33 IL25 TSLP GATA3 PMC6210917__F7 Tsc3 regulates the balance between canonical and noncanonical SPLs by promoting l-alanine incorporation into the SPL de novo synthesis pathway TH ORM2 ORM1 PMC8011202__F1 Insulin and pharmacological agents on endothelial insulin signaling DPP4 GRB2 GIP PMC5568011__F7 MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis PTPN1 SP1 IRS1 INSR PMC2725943__F7 A model of mammalian Hh signaling SUFU PTCH1 GLI3 SMO SPOP PMC9547905__F4 Hybrid network of genetic associations revealed by gene-based association studies and significant partial correlations of detected sphingomyelins, SGPP1 SGPL1 SPTLC3 SPHK2 CERS2 PMC4009339__F3 Gene network of T-ALL (early response) derived from GeneMANIA (a) and STRING (b) (NR3C1 interaction is highlighted) FOS NASP NR3C1 FKBP5 POR FBXL17 FKBP4 JUN KDM5A TRIM23 PMC3678415__F2 HDL biogenesis ABCG1 ABCA1 PMC3374768__F11 Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury EGF ERBB2 EGFR PMC6822566__F1 Complement cascade and its diverse effects of on alloimmunity and inflammation HEL-S-62p CD59 CD46 FH C1S PMC3678415__F1 HDL metabolic pathways and current drugs under development PLTP ABCG8 ABCG5 LDLR ABCA1 TG PMC11820857__F10 In darkness (A), CRY1 remains in its inactive form and is unable to suppress BR signaling because it does not interact with dephosphorylated BES1 CRY1 RFWD2 PMC9589344__F1 Targeting aldehyde dehydrogenase for prostate cancer therapies RARA RARB SIRT2 DLL4 SMAD2 GSK3B SMAD4 CCND1 HEL-S-53e PMC3221387__F1 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance, and EMT MCM3 ZEB2 DHFR DTL PMC4061808__F4 Exercise activates a wide variety of intracellular signal transduction pathways to promote neurogenesis of granule cells from neuroprogenitors in the dentate gyrus SOX2 APC NEUROD1 PROX1 PMC8405297__F6 Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum) MMP2 MMP9 CCND1 CDK4 MTOR NLRC3 BAX PMC10931536__F4 Selected epigenetic changes and host-virus interactions perpetrated by EBV nuclear antigens and latent membrane proteins BTK BCR BASH RELA TRAF6 ATF3 SYK PLCG2 CD79B CD79A STAT3 PMC10525526__F1 Phenotype Alterations in the Cecal Ecosystem Involved in the Asymptomatic Intestinal Persistence of Paratyphoid Salmonella in Chickens BAD FRS2 GRB2 SHE TRAF6 ARHA CRK PMC7842006__F3 Ingenuity Pathway Analysis (IPA)-identified immune related gene networks with score > 20 NAMPT CMTM8 LILRA4 BCR LDB2 WNK2 STAB2 IFNG PMC12145526__F2 The BMP pathway in the musculoskeletal system USP4 USP15 SMAD6 SMAD4 MTOR SMURF1 NEDD4 SMAD9 STUB1 COPS5 USP9X RNF111 SMAD1 DKFZp781O1323 PMC7783313__F5 Macrophage and bone remodeling related diseases RIPK3 CCL18 PMC7490109__F1 Possible mechanism of SARS-CoV-2 mediated innate immune response at the lung alveolar cell TLR8 CCL8 TLR7 TRAF6 CCL2 ACE2 IL1B PMC12145526__F3 BMP signaling in OP TWIST2 ANGPTL4 RUNX1 RUNX2 ATF4 MSC CCL2 DKK1 AXIN2 COL1A1 FRZB PMC3338606__F6 Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NFKB Signalling TLR4 MYD88 MAFA PMC12154924__F2 Recent Advances in Molecular Research and Treatment for Melanoma in Asian Populations KIT BRAF MTOR ROS1 PMC9167935__F9 MSC-ACE2 Ameliorates Streptococcus uberis-Induced Inflammatory Injury in Mammary Epithelial Cells by Upregulating the IL-10/STAT3/SOCS3 Pathway NLRP3 SOCS3 GSDMD STAT3 PMC12145526__F7 Crosstalk of the BMP with other signaling pathways in musculoskeletal disorders (Created with BioRender MAPKAPK2 RUNX1 SMAD2 SMURF2 APC GSK3B SMAD6 SMAD4 SMAD1 DKFZp781O1323 SOX9 PMC9372960__F1 Deucravacitinib for the Treatment of Psoriatic Disease EPO TPO TYK2 JAK3 JAK1 PMC3171509__F1 This figure illustrates the core TSC-mTor pathway, as discussed in the text TSC2 TSC1 PTEN MTOR PMC11006730__F4 Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link? RIPK1 RIPK3 ARHA PMC2742584__F7 Interaction networks of As sensitivity in yeast RFC2 WDHD1 RPA4 RAD50 MRE11A RFC3 RFC4 PMC9381515__F3 Mechanism of necroptosis leads to airflow limitation in COPD HMGB1 RIPK3 MLKL PMC8189177__F1 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes MYF5 PDGFRA MSC FGF10 LPL TG FGFR2 BMP4 PMC4130217__F4 Protomural role of tumor-associated macrophages (TAM) EGF CCL18 PMC8189177__F2 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes LIF FGF10 SFTPC PMC9381515__F1 Main detection methods of necroptosis RIPK1 RIPK3 MLKL PMC11544529__F2 DUBs in the PI3K/AKT, NFKB and MYC pathways in urologic cancers UCHL5 USP16 IGF1R CYLD USP43 EGFR PTEN TNF MTOR USP22 PMC11544529__F3 DUBs in the RAS/RAF/MEK/ERK, p53 and TGFB pathways in urologic cancers USP26 USP19 SMAD2 USP9X MDM2 GRB2 USP28 SMAD4 PMC11544529__F4 DUBs in the Wnt/Beta-catenin and Hippo pathways in urologic cancers USP34 CYLD APC MINDY1 LATS1 USP25 LATS2 PMC7415419__F5 Models for mammalian target of rapamycin (mTOR) behaviors on autophagic signaling pathway activation during osteoclast differentiation and formation TSC2 ULK1 TSC1 MTOR RHEB PMC4807884__F1 Regulation of SMN2 gene expression in SMA PRLR SMN1 PMC7415419__F6 Autophagy regulatory signaling pathways are involved in the pathological process of osteoarthritis/rheumatoid arthritis (OA/RA) ULK1 MTOR SIRT1 RHEB SIRT3 PMC5401738__F1 IL-12 activation of JAK-STAT pathway STAT4 TYK2 PMC10296674__F3 Canonical pathways derived using the IPA tool BAD SHARPIN CCND1 BCL2 PTEN SHC1 PREX2 PMC3976829__F4 Schematic illustrations for potential signaling pathway of IMF deposition in skeletal muscles regulated by GHR and SOCS3 SOCS3 IGF2BP3 GHR LPL LEPR WNT10A PMC11612504__F2 Role and mechanism of the EGFR/MET-mediated signaling pathway in cancer cells EGF BAD HGF EGFR GSK3B PTEN MTOR PMC6664158__F1 Proposed molecular mechanisms of PAX3 in glioma pathogenesis and progression MMP7 GFAP GSK3B CCND1 PAX3 PMC4339542__F4A Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells JAK1 TF STAT3 PMC3677161__F5 Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease MYB CTSS LAT2 APOC1 SLC7A7 PTGS1 CD74 DOK1 CMTM7 CMTM6 SERPINA1 IL10RA FPR1 AIF1 GRN IL10RB TNFRSF1B CSTA LILRA2 HLA-DMB PYCARD SLC15A3 CD33 IL13RA1 ARHGAP30 TGFBR1 CSF3R GPX1 MFNG HLA-DMA FCER1G IL18 BASH IFI30 RBM47 ADAM28 PTPN6 MYO1F MYO1G PBR CLIC1 PARVG RUNX1 TCIRG1 TYROBP PTPRC LYN SYK DOCK2 REL HEL-S-43 PMC10374212__F3 NLRP3: a new therapeutic target in alcoholic liver disease MYD88 IL1B CYP2E1 GSDMD PMC3133616__F4 Functional network of ion channels in T lymphocytes APC TG ORAI1 TRPM7 STIM1 PMC8397987__F3 Fructose and Mannose in Inborn Errors of Metabolism and Cancer ALDOB FBP1 KHK PMC7140408__F6 Reductive schematic of the proposed VPA induction pathway in the treatment of ADSCs toward neural differentiation SCN3A FGF21 APOA4 SLC25A24 EGFR GFAP FGFR3 SOCS5 KCNG4 KCNT2 NETO2 PMC3169181__F2 Crosstalk between host autophagy and viruses ATG12 ATG3 MTOR DKFZp686F0183 PMC8298499__F6 Untargeted Metabolomic Profiling of Liver in a Chronic Intermittent Hypoxia Mouse Model GPX4 STEAP3 ADA SLC3A2 TF CP PRNP PMC7826840__F4A Analysis of the Immune Responses in the Ileum of Gnotobiotic Pigs Infected with the Recombinant GII.p12_GII.3 Human Norovirus by mRNA Sequencing VAV1 GRB2 CD40 IL24 CD80 GATA3 ICOS PMC3921899__F1 Lipid signals and insulin resistance DGAT2 GSK3A LPA MTOR FOXO1 AGPAT5 HMFN0839 DGAT1 RICTOR GPAT4 PC GPAT2 AGPAT3 AGPAT4 ACSL1 PMC7897836__F2 Developmental Regulation of GFAP Expression CNTF PRMT1 ERBB4 BMP2 LIF GFAP SIN3A NFIA OSM PMC8929449__F5 Smoking-induced changes in buccal mucosal gene expression RPS6KB1 QK3 BMP2 SMAD2 ITGAV CCND2 PMC8929449__F9 Smoking-induced changes in buccal mucosal gene expression EPHA3 IKBKG PHLPP2 RIPK2 INSR CCNE1 CFH TIMP3 CRP SMO CSNK1A1 NTRK2 DYRK1B KCNA3 DLGAP1 CTDSPL PSEN2 FOS BMP2 SHANK1 RPS6KA5 GTF2F1 RPS6KB1 POLDIP3 STK4 MAP3K14 PMC10036590__F4 Targeting CLDN18.2 in cancers of the gastrointestinal tract: New drugs and new indications CLDN18 NRG1 MTOR PMC4942188__F1 Targeting lipid metabolism for the treatment of Anaplastic Thyroid Carcinoma TSC2 EGF TSC1 SCD LDLR MTOR RHEB HMGCR FASN CD36 PMC8834417__F1 Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives HIF1A MTOR HK2 PMC3470584__F2 Suppressed RNA-Polymerase 1 Pathway Is Associated with Benign Multiple Sclerosis CAST MYC TRAF6 RPL35A UBB APOL1 IFNG HPGD SMARCA4 ASXL1 THRAP3 POLR1D RRN3 EEF2 NRCAM DGKA MED14 DUSP10 CD27 ITGA6 SPHK1 POLRMT IKBKE GTPBP4 LRPPRC ACHE TFPI2 AFF4 TAP2 CAMK4 ATM RPS6 RUNX1 NFATC1 TBX2 CHST12 BICD2 CD44 FSTL1 DUSP26 NOL3 GNL3L NID2 DNCL1 COX17 RAD17 FHL2 TRAF3IP2 EPHA2 PMC9461676__F3 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies PDGFD VEGFC FAP IL33 VEGFA IL6R PMC9461676__F4 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies TH GCA LAIR2 FOXP3 PMC5714444__F1 Intracellular sugar-responsive gene regulatory network SIK3 SIRT1 PMC5714444__F2 The role of the HBP and protein O-linked GlcNAc conjugation in the regulation of Drosophila physiology PGM3 OGA OGT PMC7826431__F3 Open questions regarding NB–MSC interactions NOTCH2 IGF1R CCL5 STAT3 PMC3932028__F5 Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells RAPGEF4 RAPGEF2 PMC8582349__F3 MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets AGO2 DROSHA RAN PMC6985587__F2 Predicted interactions among apoplastic proteins and signaling molecules in resurrection plants during dehydration PMC4222910__F6 In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent CD14 IRAK1 CREB1 MAP3K8 MAP2K3 MAP2K6 TIRAP MAL CD36 PMC9461676__F5 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies CXCL1 CXCL5 OSM STAT3 PMC8107678__F1 Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease TRAF6 MYD88 TIRAP PMC8431455__F5 Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast Yarrowia lipolytica HEL-S-26 FBP1 tal-1 HEL60 MDH2 GPD1 PMC7955431__F1 Coronavirus Disease 2019–Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management IL18 PLG STOM ACE2 TMPRSS2 PMC9147390__F9 Evaluation of TILI-2 as an Anti-Tyrosinase, Anti-Oxidative Agent and Its Role in Preventing Melanogenesis Using a Proteomics Approach PIK3CD BMP6 MAPK3 MAP3K7 SMURF1 PAX3 MAP3K7IP1 MAPK12 ACVR2A SMURF2 TYRP1 CASP9 PIK3CA ABCB10 RAF1 DKFZp781O1323 PAF1 PMC4794363__F6 SGEF is Regulated via TWEAK/Fn14/NFKB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide ARHG TRAF2 BRCA1 PMC2921475__F1 Cord Blood Genomic Analysis Highlights the Role of Redox Balance HEL-S-2a UCP2 PMC12092457__F1 SPC25 is an important part of the NDC80 centromere complex NUF2 KNTC2 SPC25 PMC23119__F3 Roles of INH-induced genes in the context of a proposed pathway for mycolic acid biosynthesis CS INHA CMA1 PMC6794807__F5 Protein-Protein interaction network and 5 identified sub-networks of TTR-mRNAs HAL GEM MADD MRPS27 POR COCH CROCC HTRA2 MCAT CNTRL CLU WDR8 HEL-S-69p ADAR PAN2 ASNS RELA PC4 ADM GLA PMC8775450__F2 Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments SIRT2 PINK1 NRF1 FOXO3A ATF4 ADA OGG1 TFAM SIRT1 SIRT3 PMC8359037__F2 Systematic summary of survival and death signalling during the life of hair follicle stem cells APC DKK1 PMC7590459__F1 Simplified diagram of the KP IDO1 HEL-S-90n KYNU KMO PMC6539070__F2 Molecular mechanisms of adipogenesis ZNF423 BMP4 PMC8359037__F3 Systematic summary of survival and death signalling during the life of hair follicle stem cells SUFU SHH SMO PMC4064254__F2 An atlas of genetic influences on human blood metabolites LIPC OPLAH ALOX12 CRAT TYMP PAH NUBP2 DDC SCAPER SCD AGXT SLC6A20 ANKH ALX3 APOE SH2B3 MGAM GCKR PM20D2 GLS2 SLC22A4 PHGDH ADHFE1 HEL-S-61p GMPR PRODH FADS1 ABCC1 PAOX PSPH PMC3001953__F2 EGFR-mutated lung cancer: a paradigm of molecular oncology DUSP4 GRB2 CCND1 MTOR DUSP8 PMC4937026__F4 Activation of STAT3 in KSHV-infected endothelial cells CD59 CD55 STAT3 SH3BGR PMC8724243__F1 Progress on the Function and Application of Thymosin B4 LEF1 SMAD2 TGFBR1 BAX PMC6794807__F9 Five functional lncRNA-mRNA trans regulatory network CNOT2 ASNS HEL-S-51e CHD1L ACD PMC8044749__F1 Proposed immunopathological roles of circulating histones in sepsis COX2 IL16 TF PMC9010858__F2 Treatment of Retinoblastoma: What Is the Latest and What Is the Future CD2 PMC11024162__F9 TGFB signaling pathway SMAD2 SMAD4 PMC3460040__F8 Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib BRAF RAF1 ORAI1 STIM1 PMC3773516__F6 MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways DLX2 ZEB2 CREB1 TBR1 SOX5 FMR1 ARX DLX1 MEF2C PMC3601842__F1 mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development TSC2 RICTOR IGF1 PTEN MTOR DEPTOR RHEB PMC12018393__F4 Tamoxifen metabolic pathway CYP2C9 CYP3A4 PMC8359037__F7 Systematic summary of survival and death signalling during the life of hair follicle stem cells CASP3 MDM2 CASP9 FADD BAX PMC12018393__F8 Fulvestrant predominant metabolic pathway SULT1A1 UGT1A4 UGT1A3 UGT1A8 PMC9448512__F1 Canonical and non-canonical AhR signaling pathways SLC7A5 AHR CYP1B1 CYP1A1 KLF6 PMC3670316__F7 Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis RIPPLY2 WNT3A TBX6 MESP2 PMC12018393__F6 Toremifene metabolic pathway CYP2C9 CYP3A4 PMC4260983__F1 Sex hormone biosynthesis and degradation pathway CYP1B1 HSD3B1 CYP1A1 SRD5A2 UGT1A1 PMC12092457__F2 SPC25 can be used as a scaffolding platform to coordinate the assembly of the SPC25/RIOK1/MYH9 trimer complex, triggering RIOK1-mediated phosphorylation of MYH9 Ser1943 MYH9 RIOK1 KNTC2 SPC25 PMC5228523__F4 MicroRNA-gene interaction networks of the MAPK signaling pathway CHUK MAPK14 CRK HEL-S-31 MAPKAP1 CRKL CACNA1C CCNE1 CCNI2 MAP2K1 MAPK6 BCR E2F2 MAP4K3 F3 RAF1 DUSP2 PMC7772402__F1 Schematic presentation of early steps of SARS-CoV-2 life cycle SI ACE2 TMPRSS2 PMC4728678__F2 Lipid rafts as platforms for cell signaling CXCR4 SRC FADD PMC125938__F8 An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype XLKD1 CD34 PROX1 PMC5138100__F6 New Insights into Protein Hydroxylation and Its Important Role in Human Diseases EPOR dik MAPK6 HUWE1 PMC4075164__F2 Multiple intracellular signal transduction pathways are activated by GH GHR SRC PMC4194224__F7 Expression of Suppressor of Cytokine Signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury SOCS3 STAT3 BAX PMC7198187__F1 Immunomodulation in COVID-19 STAT1 COX2 TLR4 STAT2 IRF9 CCL2 TIGIT MYD88 ACE2 IRF4 STAT3 PMC4235760__F1 MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS ATF4 EIF2A TXNIP CASP2 PMC5968394__F2 PI3K/Akt signaling facilitates ROS detoxification and redox homeostasis KEAP1 GSK3B SGK1 PMC2785932__F3 Four pathways by which the EBV latent membrane protein 1 (LMP1) is thought to signal inside cells GCKR TRADD ATF2 TRAF1 TRAF3 JAK3 TRAF2 PMC2383880__F7 A logic-based diagram of signalling pathways central to macrophage activation SOCS3 NFKB2 RELA LMNA TNF CASP4 PMC2383880__F1 Manual layout of Type II interferon signalling (IFNG) taken from the integrated pathway diagram (Figure 2) IL18 GAS1 IFNG PMC4914733__F7 Proposed signaling mechanisms mediated by Lipoxin A4 in preventing intestinal epithelium cells from intestine ischemia reperfusion (IIR) injury FABP2 DAO KEAP1 PMC6546329__F3 Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome OTC ASL PMC3711139__F4 Preparation of Dihydrothieno- and Dihydrofuranopyrimidines BOC PMC10815168__F1 Schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR ELAVL1 ITSN2 HSD11B2 WNK1 TIMP3 ITSN1 PTEN TUG1 SGK1 PMC6370674__F2 Pathway map of Notch signaling (A) and Th1 differentiation (B) in KEGG TH SET STAT4 ACHE CLU PMC6598836__F4 Essential metabolism and mitochondrial regulation on B cells (A) and Antibody-Secreting Cells (B) CD9 BCR CD40 PMC7699985__F1 VEGFR-2 signaling and 4 types of anti-angiogenic agents VEGFA SRC PMC8779539__F1 Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID PMC5568615__F2 COX-2/PGE2pathway in colitis-associated CRC CXCL1 COX1 PMC7335982__F6 Signaling pathways and deregulation of its modalities such as Stat3/mTor, Hedgehog, Notch and Wnt/-catenin cascade defined as a new therapeutic strategy in the prevention of cancer extension, especially CSCs growth behaviors modification () APC SMO PMC9366743__F6 Beta-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGFB/Smad Signaling Pathway SMAD2 TGFBR1 SMAD4 PMC12039932__F5 Nanomaterial-based DDSs treat OA by targeting chondrocytes WNT3A BCL2 BAX PMC9288068__F4 Exploring immunotherapy in colorectal cancer TH STAT1 CXCL10 CXCL9 CXCL11 POLI PMC12039932__F3 Nanomaterial-based DDSs treat OA by targeting synoviocytes MMP3 TRPA1 TNF MTOR PMC3215775__F1 Molecular mechanisms through the Epidermal Growth Factor Receptor pathway EGF EGFR GRB2 PMC6487669__F16 De Novo Pyrimidine Biosynthetic Pathway Diagram CMPK2 UMPS CAD DHODH CTPS2 PMC12039932__F2 Nanomaterial-based DDSs treat OA by targeting macrophages CGAS MTOR TLR3 TRPV1 PMC8085542__F1 Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH FGF21 GIPR GSK3B GIP FGFR4 NR1C1 CYP7A1 GHRH GCGR IGF1 GHR LDLR FGF19 GHRHR NR1A2 PMC7105304__F10 Leptin-mediated MTP regulation through long- (ObRb) and short- (ObRa) forms of leptin receptors TF STAT3 PMC10749620__F2 NRF2 peptide with its seven Neh domains and their roles MAF KEAP1 RBX1 RXRA PMC10749620__F3 KEAP1-NRF2-ARE pathway MAF KEAP1 RBX1 PMC10749620__F4 KEAP1-NRF2 by P62 non-canonical pathway KEAP1 RBX1 PMC7823450__F1 Metabolic pathway of oxysterol sulfates CYP27A1 CH25H CYP46A1 PMC7823450__F2 Novel regulatory pathway of oxysterol sulfation CYP27A1 BAD PMC6341466__F1 Expanding the Clinical and Molecular Characteristics of PIGT-CDG, a Disorder of Glycosylphosphatidylinositol Anchors PIGU PIGF PGAP1 PIGT PIGO PGAP2 PGAP3 PIGW PIGY PIGX PIGS PIGV PIGK PIGN DPM2 HEL-S-5 GPAA1 PIGC PIGH PIGM PIGA PIGP PIGL PMC10948547__F1 Molecular mechanisms of TLR4 in osteoporosis development HMGB1 TLR4 RUNX2 MYD88 S100B CUL4A KDM4A PMC3273847__F1 Innate Immunity in the Host Defense Against intestinal Bacterial Pathogens TLR7 TLR4 NOD1 IRF7 TRAF6 IRF3 MYD88 IL1B NOD2 TLR3 PMC8391638__F2 Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research ARHA RHO PMC6398501__F8 An integrated model for ROS mediated clearance of VAP(P58S) aggregates via UPS HEL-S-44 VCP MTOR PMC4905335__F1 Mechanism of retention of BRCA1/BARD1 complexes at DNA double-strand break sites RNF168 RNF8 RIF1 ATM PRDM2 MDC1 BARD1 H2AX BRCA1 PMC6329923__F8 Proposed model of the mechanism of GALNT6-mediated regulation of proliferation and metastasis thought Beta-catenin /MUC1-C signaling in breast cancer APC GALNT6 CCND1 PMC5104508__F1 Classical view of progressive linear cascades in the asymmetry-determining pathway NODAL PITX2 SMAD2 FGF8 SHH SMAD4 SMAD1 PMC7915278__F5 Selected network of 138 proteins that were found in a functional screen for proteins involved in the pathway in cancer (KEGG: hsa05200) PIK3R1 MAPK8 MAPK3 SMAD2 RALA SMAD4 PLCG2 BCL2L1 RALBP1 CRKL PRKCA PIAS2 BCR WNT4 MSH6 CASP9 DVL2 HDAC2 MSH3 MSH2 SOS2 LAMB3 RALB CTNNA1 RBX1 CRK LAMA3 MAX NFKB2 ITGA6 TRAF1 STK4 GRB2 BCL2 ITGAV LAMC1 TGFB1 CDC42 PLCG1 PML IGF1R IKBKG CHUK TGFBR1 CTBP1 TGFBR2 TPR MTOR CCDC6 RXRB JUP TFG BIRC3 FH ARAF KIT MMP9 ARHA RAC1 ITGB1 DVL3 CBL HEL-S-125m IKBKB CASP3 CREBBP EP300 MAP2K1 SPI1 PIAS1 PIK3CA TRAF2 CYCS PIK3R2 PMC4979485__F1 LINP1 regulation and role in the NHEJ DNA-repair pathway ATM EGFR H2AX PMC7915278__F4 Functional networks of proteins involved in the following pathways: (A) B-cell receptor (BCR) signaling pathway (hsa04662), (B) cellular adhesion molecules (CAMs) pathway (hsa04514), (C) PPAR signaling pathway (hsa03320) PIK3R1 L1CAM CNTN1 GSK3B NRAS APOC3 SPN SELL ACOX1 ACSL6 ACSL5 CYP27A1 DAPP1 VAV3 BCL10 F11R HLA-DPA1 SOS2 HLA-DOB HLA-A VCAM1 HLA-DMB FABP5 PECAM1 CD19 RAC1 CD79B CD79A HLA-DOA PTPRF MADCAM1 PTPRC DBI IKBKB NFKBIA HLA-DPB1 NFATC2 CPT1A LYN SLC27A1 CD40 SYK CR2 ACSL3 VAV2 HLA-E PIK3CD CD58 CD99 SLC27A2 PPP3CA FACL4 PPP3CC CPT2 INPP5D CHP1 ACSL1 PCK2 VAV1 NCAM1 SIGLEC1 PLTP ITGA6 GRB2 GLG1 ITGAV EHHADH IKBKG CHUK HLA-DQB1 ITGA4 CD81 BTK BASH CD2 PTPN6 SLC27A4 NFATC1 ITGB1 NFKBIB ITGAM MAP2K1 CD72 ICAM3 SDC4 RASGRP3 NFKB1 ITGB7 CD22 RELA MPZL1 PIK3CA RAF1 SOS1 ACOX3 ACADM PIK3R2 SCD5 PMC4841712__F1 Regain control of p53: targeting leukemia stem cells by isoform-specific HDAC inhibition PIM1 ATM HDAC8 USP22 SIRT1 PMC5435887__F1 Main genetic and signaling pathway alterations in UMs and CMs KIT MARCKS BRAF RASA2 NRAS PTEN RHO RAC1 MTOR PREX2 PLCB4 NF1 ARF6 TRIO BAP1 PMC11155398__F4 Biological functions of SUMOylation cascade in tumors YTHDF2 SUMO3 METTL14 METTL3 TRIM21 SAE1 RNF146 TRIM28 WTAP IRF-1 CBX4 SUMO1 PMC2670969__F4 PBT-1 induced genes in different pathways according to the KEGG and BIOCARTA pathway databases BAD CDK2 GHR CCNH CDK4 CDC2 MTOR CDK7 CDK6 PMC7166496__F5 Regional signaling pathway analysis of the genes associated with heart diseases HEL-S-26 CS ACSS1 HADHB DLD HEL-S-87p DLAT SDHA HEL-S-162eP ALDH9A1 PMC6559935__F1 Leptin and leptin receptor activation pathway SOCS3 STAT3 PMC11155398__F2 Biological significance manipulated by SUMOylation in tumors SUMO3 RNF168 CSNK2A1 SENP1 PIAS1 MORC2 RNF146 TRIM28 IGF2BP2 FOXK2 SUMO1 PMC5866057__F1 MTOR signaling pathway with potential contributions from GABA and Glu receptors SNCA CS VEGFA GIP PTEN CAB39 RHEB TSC2 IGF1 TBP ABAT AVP PRODH BCL2 PMC3967868__F1 Drug resistance mediated by AEG-1/MTDH/LYRIC AGO2 DPYD MMP9 MYC SND1 MTDH DKFZp686F0183 FOXO1 PMC5983605__F2 Diagram of WNT (Wingless-type) signaling pathway APC GSK3B LRP5 LRP6 PMC2811646__F4 Molecular targets in NFKB pathway modulated by PEITC and SFN COX2 SFN TNF PMC2811646__F3 Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN MAF KEAP1 SFN GSTM1 UGT1A1 PMC8068835__F11 Summarized interconnection between PC synthesis, trans-sulfuration pathway, folate cycle, methionine cycle, polyamine pathway, and trypanothion synthesis HEL-S-61p PC PEMT PMC9251307__F1 Molecular Mechanism of Caffeine in Preventing Bronchopulmonary Dysplasia in Premature Infants KEAP1 ATF4 HEL-S-44 PMC4817351__F8 Molecular pathways of proliferation, survival and senescence RET ALK CDK2 NTRK1 MDM2 CDK4 PTEN MTOR CDKN2A ROS1 CDK6 PMC8788178__F2 Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC11835119__F4 Phyllanthus emblica–active components–target–pathway network CSNK2A1 CA14 MAPK3 GSK3B MAOA GCK CA3 GBA2 SCN9A TRPV1 HEL-S-26 GRM2 FGFR1 GRIN1 HEL-S-11 MAPK1 GABRA2 CHRM2 UGT2B7 CA7 ABCB1 NTRK2 ADK OPRD1 HEL-S-28 MAPK10 VEGFA CDK5 CHRNB3 GABRB2 TNF PDE2A CHRNA3 CHRNA6 KCNJ3 HEL-S-22 SLC6A3 GABBR1 CHRM1 HTR1A HEL-75 RORA BRD2 DUSP3 HEL-S-72p CA12 CASR SLC1A1 BRAF CHRNA7 TNK2 ACHE MTOR CACNA2D1 CYP1A2 GABRB3 SHBG CYP2C19 KDM5C KCNJ6 APP ABCG2 PBR OPRM1 MMP9 PTGS2 DDX3X NR3C2 HRH3 FAAH CA9 HEL-S-162eP DYRK1A CASP3 ADORA2A ALPL MAP2K1 CHRM3 ADRA2A KCNK9 ABCC1 ERN1 GRIK1 PIK3CA CA5B CA5A RAF1 SCN5A SCN1A ADRA2B GABRA6 GABRA3 CHRNB2 STAT3 HTR1D PMC3443126__F7 H2O2-modulated permeability increase and cytoskeleton reorganization via MARCKS phosphorylation in endothelial cells PLCG1 MARCKS RAC1 PMC6540205__F3 Activation of the prolactin signalling pathway in the mink uterus in activated versus diapause states TH GCK PRL PMC8126061__SF1 Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells CCNB1 CDC2 PMC11835119__F7 Exploring the mechanism of action of Phyllanthus emblica in the treatment of epilepsy based on network pharmacology and molecular docking MLNR HEL-S-62p QRFP APELA UTS2R GRPR GIP CALCR LPA MLN GHR KISS1 TACR3 LEPR TRHR PTGIR GHSR GIPR PMCH NR3C1 PRLHR PTH SCTR LHB LTB4R TACR2 GHRL TSHR VGF CRH OXTR TRH PRLH UTS2 AVP SPX GHRHR FSHR PMC6540205__F1 Activation of the PI3K/AKT signalling pathway in mink uteri in activated versus diapause states ME1 BAD MEI1 EBP MYC PTEN RAC1 EIF4E MTOR BRCA1 RHEB TSC2 BCR SYK BOLL CD19 PMC8600110__F1 Receptor-Mediated NETosis on Neutrophils HMGB1 CXCR1 MPO TLR9 NOD2 NLRP3 TLR8 TLR7 TLR4 SYK TRPM2 ACE2 TMPRSS2 PMC5445935__F2 Correlates of metastatic melanoma response to checkpoint inhibition CTLA4 B2M PMC8711145__F6 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis NLRP3 RIPK1 TLR4 MYD88 IL1B FADD PMC3372530__F2 Diagram of genes that have been implicated in susceptibility to CL and ML disease caused by L FLI1 SMAD2 TGFBR1 COL1A2 TGFBR2 SMAD4 IL6 SP1 IL6R STAT3 PMC8711145__F2 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis NLRP3 CASR GPRC6A CMPK2 TXNIP TNF NOD2 MAVS GSDMD PMC6574129__F5 Aurora kinase plus BTK blockade inhibits the chronic active BCR pathway and induces apoptosis in DH/DE-DLBCL SYK PLCG2 HEL-S-162eP PMC3291789__F1 Targeting the p53 signaling pathway in cancer therapy - The promises, challenges, and perils TIGAR SCO2 DKFZp781B1423 LIF GPX1 XPC GADD45A DDB2 TP53INP1 PERP MDM2 SESN1 MSH2 SESN2 BAX PMC9409103__F3 Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19 TBK1 CGAS IRF3 PMC5140782__F1 Metabolic rewiring in melanoma PYCR2 PCK1 SHMT1 MYC PDP2 PHGDH HEL-S-26 GOT2 GPT2 ASNS DHFR MPC1 MPC2 HEL-S-133P GLUD1 GLS PMC11948033__F3 Modulation effect of TEVs on CD8+ T cell HLA-G OGT BMI1 PMC5140782__F2 Metabolic rewiring in melanoma NF1 BRAF HMGCL PMC11948033__F4 Treatment strategies to reversing immune escape EPCAM PMC7013084__F1 CSCs alter the composition and functional properties of immune cell subsets, which results in an impaired CSC recognition and elimination by the immune system SIRPA CD47 CCL5 CCL2 FOXP3 PMC9686704__F1 Research Progress on Mitochondrial Dysfunction in Diabetic Retinopathy ARHA HEL-S-162eP PMC3501207__F1 Cholesterol Accumulation Regulates the Expression of Macrophage Proteins Implicated In Proteolysis and Complement Activation HEL-S-62p CD14 HSP90AB1 IL1RN ARHA HLA-C ITGAM C1QB C1QA IGF1 CFH F2 opn GRB2 CFP HEL-S-93 APOE PMC9258520__F1 Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications SIRT2 NAMPT NADK NNMT NMNAT3 SLC22A3 NRK SIRT3 SLC36A4 SLC12A8 SLC7A5 NAPRT SIRT7 SLC25A51 SLC5A8 NMNAT1 KYNU SIRT4 KMO SIRT5 SIRT6 NMNAT2 SARM1 SIRT1 PMC4964437__F2 Lipid mediators and HIF1A signaling in hypoxic prostate cancer (PCa) cells COX2 GSK3B SRC SPHK1 PMC4494663__F14 New Biology of Estrogen-induced Apoptosis Applied to Treat and Prevent Breast Cancer BCL2 TNF FADD PMC4604214__F3 Key Figure: Developmental and Disease-associated Pathways Regulated by Chromodomain Helicase DNA Binding Protein 7 (CHD7).CHD7 can affect the activity of several signalling pathways that control development SOX2 GBX2 SEMA3A TBX1 GLI3 FGF10 FGF8 OTX2 SMAD1 MLL2 PMC11742855__F4 Сomplex interplay between cell cycle-related genes and their influence on various signaling pathways in NETs RICTOR RET EPCAM EGFR BCL2 CDK4 HEL-117 EZH2 MTOR PMC11280205__F5 Mechanism in the development of a higher 2D:4D ratio SMAD2 SPHK1 NOTCH3 PMC5855762__F1 The molecular signaling pathways underlying the effects of CC2238/AANP in endothelial cells, smooth muscle cells, and platelets GIP PTEN GAL ATP8 PMC7693470__F1 Schematic simplified representation of thyroid hormone synthesis GPX2 TG PMC8564336__F1 Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma WNT3 GSK3B PTEN CDH2 PMC11506032__F5 Pathophysiology, Treatment, and Prognosis of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome: A Review STAT1 CXCL13 STAT2 VEGFA MTOR STAT3 PMC8016949__F1 Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy DGAT1 DGAT2 PMC5214845__F3 Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors TRAF6 IRF3 MYD88 MAL PMC3428377__F3 Signaling pathways for estrogen production and action PI3 JUND JUN PMC4522054__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks IGF1 MPO VCAM1 CRP TF PMC8015649__F3 Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation PC OGA OGT PHGDH PMC3706484__F5 Xenogeneic-Free Protocol for Isolation and Expansion of Human Adipose Stem Cells for Clinical Uses F13A1 EPOR FCRLA IL1R2 EZR HBEGF B2M HLA-DRB1 IL10RA HLA-F PMC11980100__F9 Histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks ATM RAD50 H2AX MRE11A PMC2913378__F3 Signaling pathways that mediate actomyosin-dependent disruption of the epithelial barrier in inflammation RHO TNF IL1B IFNG PMC8038106__F1 Molecular pathophysiology of hereditary hemorrhagic telangiectasia (HHT) BMPR2 SMAD2 PAH PMC8469305__F5 Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NFKB Signaling Pathway TG IL1B FASN PMC8375232__F4 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma YTHDF2 EIF3A AAG1 PMC12084965__F7 Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis NLRP3 GAL TNF GSDMD PMC8375232__F5 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma WNT2B PMC8004548__F1 Interleukin-6 classical and trans-signaling SOCS2 ADAM10 ADAM17 SOCS1 PMC6220136__F1 EGFR signaling and generation of Treg and tol-DC EGF AREG EGFR STAT3 FOXP3 PMC7230049__F1 Rationale for homocysteine removal by the administration of a full array of activated micronutrients HEL-S-61p MTR VIT CHDH DHFR MTRR PMC3816537__F3 Pathway based analysis of high ranking composite score genes reveals key signaling pathways associated with PDAC clinical progression CASP3 DFFB DFFA EGFR SRC PTEN MTOR FADD CBL PMC4080280__F4 Stage-specific expression of individual genes in Ras and Wnt pathway orchestrate cardiogenesis PIK3CD EGF IKBKG SOST GSK3B PTEN MAP2K3 MAP2K6 PI3 BMPR2 MAPK12 PTPN11 TEF MDM2 FGL2 JUN ACTR2 SOX2 FOS MAPK7 LIF APC LRP6 MAP2K5 ERAS MAPK6 MAPK4 BMPR1A GRB2 SMAD1 STAT3 PMC8038106__F2 Targets of bevacizumab and tacrolimus BMPR2 HEL164 SMAD1 DKFZp781O1323 PMC8456159__F7 Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus CEMIP DPF3 IL23R STAT3 BAX PMC3225503__F6 Pathway model based on vision related TMT-associated gene expression changes indicating a possible mechanism for TMT elicited neurobehavioral changes CRX ARR3 RHO PMC6451295__F3 Different sources of EVs in the cancer-to-stroma communication network SIRPA CD63 EGFR FGF19 PMC5140782__F3 Metabolic rewiring in melanoma GPX4 GPX1 HEL-75 HEL-S-44 ARHA PMC8529160__F4 Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury ADAM10 ADAM17 PMC4973254__F5 Predictive Immunohistochemical Markers Related to Drug Selection for Patients Treated with Sunitinib or Sorafenib for Metastatic Renal Cell Cancer RET VHL PTEN PMC4882277__F7 Proposed mechanism by which miR-21 links hepatic lipid accumulation and the development of cancer CCNB1 CCND1 PMC3410018__F5 Immune cell types implied to be involved in celiac disease by pathway analyses TNFSF6 CCR3 PTPRK APC CD80 CTLA4 IL18RAP IL1B ICOS IFNG STAT3 SH2B3 PMC7339077__F2 Biomarkers of primary and acquired resistance occurring in the (A) tumor microenvironment (TME), (B) in the tumor, and (C) host factors PTEN TIGIT LAG3 B2M PMC4899229__F1 Type III IFN signaling pathway STAT1 TLR7 TLR9 STAT2 IRF3 STAT3 PMC8117215__F2 Early Emergence of Adaptive Mechanisms Sustaining Ig Production: Application to Antibody Therapy ELF2 MBTPS2 ATF4 XBP1 PMC5935119__F2 Genetics of coronary artery disease: discovery, biology and clinical translation ANGPTL3 ANGPTL4 LPL PMC5334259__F2 Cellular unfolded protein response mechanisms XBP1 PMC7149109__F1 Antiviral innate immune response IFIT3 TBK1 STAT2 TRAF3 IFNAR2-IL10RB TRAF6 HEL-S-92n IRF3 MYD88 IL10RB STAT1 TYK2 JAK1 MAVS PMC7736127__F1 Neuronal insulin signaling and brain structure in non-demented older adults: The ARIC Study IGF1 GSK3B IRS1 PMC5074855__F7 Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans NRG1 PMC7682536__F1 Spectrum of RAS-MAPK pathway disease genes and associated RASopathies RIT1 CS BRAF GRB2 SPRED1 RRAS SHOC2 RAF1 HRAS CBL PMC3492703__F1 Biosynthesis and posttranscriptional processing of miRNA DGCR8 DICER1 DROSHA PMC3943767__F3 Proteolytic pathway that controls glucose uptake in fat and muscle UBL3 TBC1D4 IRS1 PMC3775123__F2 Signaling modules that are important therapeutic targets to counteract muscle wasting IGF1R IGF1 SMAD2 JUNB MTOR SGK1 PMC3632064__F3 Motor axons release Agrin and ACh MUSK LRP4 CRK CRKL PMC3775123__F1 Signaling modules responsible for autophagy-lysosome pathway in the adult PINK1 TFEB ATG12 ATG3 KIAA1632 BNIP3L MUL1 BNIP3 ATG10 DKFZp686F0183 GABARAP PMC7232389__F6 Eukaryotic initiation factor 2 (EIF2) signaling pathway RPL7A RALA RPL13 RPL9 RPS7 RPS26 RPS24 RPL12 AGO1 FAU EIF3K EIF3D EIF3M RPL3 PTBP1 RALB RPL39 RPS13 RAP1A GRB2 EIF3S3 RPS3 RPL7 AKT3 EIF4A2 RPL27 NOX4 RPS5 RPS2 ATM RPL21 EIF4A3 RPS6 RPS12 RASD2 RPL38 RPL6 RPL4 RPS8 RPS9 EIF3C RPL8 PIK3C2B AGO2 RPL28 SPI1 RP1 RPL41 RPS21 PIK3R2 RPS23 PMC7232389__F7 Sirtuin signaling pathway SIRT2 SDHC ACSS2 PFKM PAM16 MTOR RRP9 HSF1 NR1C1 PPIF APP ACLY ATG14 PPARG HEL-S-133P SDHD SDHA SDHB PMC8259493__F2 Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies PKD1 MTOR PMC6627458__F8 Mechanisms underlying the anti-inflammatory effects of oxytocin (OT) on lipopolysaccharide (LPS)-stimulated microglia TLR4 ATF4 IL1B PMC5687887__F1 Summary of pathways and signals discussed in this review that induce NK cell activation and/or NKG2D ligand expression in tumor cells and in virus-infected cells CGAS HDAC3 ATM ATF4 IRF3 ATR PMC8005482__F1 Inactivation of tumor suppressors in GBM cells that affect GAM biology CCR5 CCR2 CX3CR1 YAP1 CX3CL1 CCL5 PTEN CCL2 TNF MTOR NF1 SRC STAT3 PMC9678997__S1 Tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis TH PINK1 LRRK2 PMC4747365__F7 Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells CASP3 CASP9 BAX PMC3743775__F6 Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling STAT1 IRF3 STAT3 PMC9237930__F1 New dawn for cancer cell death: Emerging role of lipid metabolism ACAT1 SQSTM1 CPT1A ROCK1 EGFR ALOX12 LDLR ABCA1 LPCAT2 HMGCR FASN CD36 PMC9237930__F2 New dawn for cancer cell death: Emerging role of lipid metabolism ME1 INSIG1 FADS2 WDR76 SIRT6 ADFP SREBF2 SIRT1 FASN CD36 PMC7335402__F3 Relevant biological network containing the DPTs and their associated genes () was constructed using Cytoscape version 3.8.0 ATG12 ATG101 ATG10 DKFZp686F0183 PMC5516940__F3A Proteomics analyses of prostate cancer cells reveals cellular pathways associated with androgen resistance BAD EBP MYC PTEN RAC1 MTOR RXRA TSC2 PI3 BCR MDM2 CCND1 SYK RBL2 CD19 PMC5043055__F5 Pathways leading to lignin and heteroxylan in maize pericarp at stage R3 CAD JCAD PMC9170863__F4 TEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review) SOX2 TRAM1 DDC EGFR KLF4 DKK1 GAL MTOR AXL PRAF2 STAT3 PMC6881378__F11 Proposed mechanisms for the role of MC mediators in response to tumor cells GAL PCNA CP PMC6368395__F3 Immunosuppressive agent-induced cell-intrinsic tumorigenic pathways CXCR3 HGF ATF3 STAT3 PMC6858953__F1 Claudins inhibit multiple oncogenic pathways IGF1R PDK2 CCND1 LATS1 PTEN PMC6368395__F4 Oncogenic viral infections in post-transplantation malignancies EGFR FADD PMC8413833__F8 Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas CDK2 TIMP3 BAX PMC3887921__F2 Regulation of autophagy by nutrient signals TSC2 ULK1 TSC1 AMBRA1 ATG101 UVRAG MTOR RHEB PMC4905265__F1 Schematic description of multiciliogenesis MCC FLNA ARHA PMC9364625__F5 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity TLR8 AHR MTOR HEL-S-133P FASN CD36 FOXP3 PMC9364625__F3 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity CCR7 CCR4 GCK CCR8 PMC9364625__F4 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity PTEN TFAM FOXP3 PMC4314111__F2 Rise of regulatory RNA AGO1 CTCF DROSHA EZH2 PMC7143458__F3 Location of differentially expressed genes (indicated by red boxes) in the purine metabolic pathway OMP PMC6889944__F7 Proposed antifibrotic mechanism of G SMAD2 SMAD4 PMC10530916__F8 Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A Potential Therapeutic Target of Ovarian Cancer STAT1 NFKB1 RELA IL6 SP1 HIF1A PPARG STAT3 PMC8687677__F1 The Role of Gut Microbiota in Diabetic Retinopathy NLRP3 TLR4 HP MYD88 PMC9364625__F2 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity MTOR CD36 PMC6341905__F1 TGF and RBM5 signaling cascade EGF BAD PTEN TGFA RBM5 BAX PMC8199164__F4 Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer REV1 PLK4 MDC1 MRE11A BRCA1 RNF168 TIMELESS RNF8 NRP1 RAD50 RAD51 ATR H2AX PMC4449425__F2 Activation of canonical (Wnt–Beta-catenin) pathway APC GSK3B LRP5 LRP6 PMC6934488__F6 Metabolic network diagram between phenylpropanoid biosynthesis pathway, pentose phosphate pathway and proline metabolic pathway PRODH CAD PMC9043410__F4 Structure-based identification and pathway elucidation of flavonoids in Camptotheca acuminate TH CAST PMC7567033__F1 Scheme of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the regulation of autophagy process ULK1 EGFR AMBRA1 PTEN ATG101 EIF4EBP1 DEPTOR RHEB TSC2 NF1 TSC1 UVRAG ATG14 PMC11414392__F11 RUNX1-MUC13 regulatory mechanisms in CRC metastasis MUC13 RUNX1 CCND1 AXIN2 PMC9226665__F6 Endotoxins Induced ECM-Receptor Interaction Pathway Signal Effect on the Function of MUC2 in Caco2/HT29 Co-Culture Cells ROCK2 TNC HSPG2 MYL2 IBSP CD44 SRC ARHA LAMB2 ITGAV AGRN PMC8615041__F1 IL-36A and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling CD14 ATG12 ATG3 FOS IRAK1 IL36A IRAK2 IRAK4 MYD88 MTOR DKFZp686F0183 TLR4 JUN TIRAP STAT3 PMC7272533__F1 IL-18 signaling pathway TRIL PTMS CHUK BAD FOS DEK ATF3 DES PTEN NACA POR PRKCA IL18 ACADS HEL-S-11 RELA LCK REL ATR JUN FADD ACR CYCS BAX PMC8070103__F1 RAF-MEK-ERK pathway is activated by H/K and NRAS upon extracellular stimuli BRAF NRAS RAF1 ARAF PMC2711664__F1 Signal transduction mechanisms implicated in leptin action MTOR STAT3 PMC8070103__F4 RAF1 negatively regulates the proapoptotic Hippo pathway by binding to MST2 upon growth factor stimulation NRAS LATS1 RAF1 PMC10982327__F2 Molecular pathways involved in animal glaucoma models at the level of retinal ganglion cell SMAD2 SMAD4 SRC PMC8163539__F4 Systematic Pharmacology Reveals the Antioxidative Stress and Anti-Inflammatory Mechanisms of Resveratrol Intervention in Myocardial Ischemia-Reperfusion Injury PDC CD40 MIP RAC1 MYD88 tal-1 TIRAP PMC2869556__F1 Metabolic folate pathway MTR DHFR MTRR PMC2898136__F6 Eicosanoids and cancer COX2 CXCR4 FGF2 EGFR LTB CCL2 CDC42 PMC2898136__F3 Eicosanoids and cancer MMP2 EGFR GSK3B CCR7 SRC PMC2898136__F1 Eicosanoids and cancer COX2 LTA LTB PMC5940378__F7 Proposed aPPD anti-prostate cancer mechanism MDM2 BAX PMC4649380__F5 CTGF Signaling Network ModelWe compiled a list of molecules known to be associated with hematopoiesis () and reported to interact directly or indirectly with CTGF and each other using EXERBT text mining and Pathway Commons, respectively ( and ) FZD3 EGFR SMAD2 GSK3B MYC TGFBR2 SMAD4 PTEN FZD1 CDK6 CCNE1 FZD2 CCND1 FZD7 CDK4 FZD10 CCNE2 ITGB3 FOS CDKN1B LRP5 FZD4 FOXO1 FZD5 EP300 CDKN1A CDK2 ITGAV TGFB1 SKP2 IGF2R FZD8 PMC7962393__F7 Functional Prediction of the Key Genes Involved in HBV Associated HCC KIF23 CCNA2 TRADD SFN SMAD2 MYC CENPF CCNH SMAD4 RB1 GINS1 TOP2A DBF4 ORC2 CDK6 KIF11 DEPDC1 PRC1 TBP ATM KNTC2 CCNB1 CDCA3 CDC2 PRKDC MKI67 RAD21 NUSAP1 SKP1 CENPE STAG1 HDAC1 AURKA MCM3 HMMR MCM2 SMC3 CDK2 NEK2 KIF20A ZWINT SMC4 TGFB1 PCNA SKP2 PMC4928090__F4 Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish IL10 PRKAA1 PYGB CRK CCNG2 CBL PPP1R3A GYS2 TNFSF6 FOXO3B CDKN1A PPARGC1A CCNB2 IL7R CCND1 MAPK1 SGK1 STAT3 PMC2518078__F1 Cotargeting survival signaling pathways in cancer TSC2 BAD TSC1 GRB2 PTEN EIF4E RHEB PMC7439842__F1 Known and speculated roles of NADPH oxidase (Nox) and ROS in G-protein-coupled receptor (GPCR) transactivation of epidermal growth factor receptor (EGFR) EGF EGFR SRC PMC7312018__F4 Tamoxifen modulation of membrane and nuclear estrogen receptor (ER) signaling EGF HEL-S-28 EGFR SRC TGFB1 TF GPER PMC6319021__F5 Proposed mechanism for kCer acting as a Sema3A-like ligand LIMK1 FYN SEMA3A NRP1 RAC1 PMC20092__F5 A model for the v-Crk-mediated signaling pathway GRB2 CRK JUN PMC5852877__F1 TLR4 intracellular signaling pathways TBK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP TAB3 PMC12023698__F7 Working model of AMPK-ULK1 activating autophagy in nZnO induced bone regeneration ULK1 RUNX2 MSC SP7 PMC9520460__F10 Complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment HEL-S-62p HP CD163 PMC10891054__F9 PART1/AC007728 FCGBP PMC7757025__F3 Signal transduction of BII spectrin in tumor EPCAM FANCD2 YAP1 SMAD2 APC GSK3B LRP5 SMAD4 LRP6 IL6 HES1 TLR4 IGF2BP3 CDK4 STAT3 PMC9224204__F4 Chronic LY341495 on Hippocampal mTORC1 Signaling in Mice with Chronic Unpredictable Stress-Induced Depression EIF4E BDNF EIF4B PMC8598308__F5 Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients RIMS1 TRPV4 MGLL NAPEPLD ABHD6 DAGLA FAAH CNR1 PMC5116860__F3 Mechanism of action of metformin HEL164 PKD1 PTEN EIF4E MTOR PMC6513775__F4 Possible site of action of beta (B) asarone in apoptosis, cell proliferation and growth CDK2 BAX PMC8450533__F4 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells NF1 RAD1 BAD DAO BIK RHO CAD CRK LAT RGL2 CDC42 VAV2 PMC8450533__F5 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells BAMBI VASP BAD E2F4 NODAL HEL-S-28 SMAD2 THSD4 SMAD6 SMAD4 SHE SKP1 ARHA RGMB TNF SMURF1 IFNG SMURF2 PMC4889429__F2 MiR-155 on virulent (green) and avirulent (yellow) Mycobacterium species infection in macrophage PKIA TNF PMC8326283__F8 Liquid–liquid phase separation in human health and diseases SPOP PMC12230579__F7 Network of compound-reaction-enzyme-gene LIPC OPLAH CS GPT AGK ALDH3A2 CRAT HMOX1 UGT2B15 PNLIPRP2 PLD2 LYPLA2 GPT2 ALDH16A1 LIPG OGDH UGT1A1 SDHA UGT1A3 ChAT GCLM DLD NAGS PEMT LIPE LIPA CHKA ALDH1A3 HEL-75 CHKB ALDH3A1 GLS PMC8326283__F6 Liquid–liquid phase separation in human health and diseases CGAS LCK ZAP70 GRB2 SOS1 LAT PMC7696687__F3 Various physiological roles of intracellular visfatin (iNAMPT) SIRT2 SIRT7 NMNAT1 NADK SIRT6 NMNAT2 NMNAT3 SIRT1 NRK SIRT3 PMC5518130__F4 Differently expressed protein-coding genes and lncRNAs participating in the AMPK signaling pathway via DAVID KEGG analysis TSC2 EEF2K IGF1 F2 INS MTOR POC1A RHEB CFTR INSR CD36 PMC3875959__F3 Proposed model for the role of lncRNAs in RB pathway CCND1 CDK6 PMC4470747__F1 Innate Immune Evasion In Re-Emerging RNA Viruses TBK1 AGO2 IRF7 TRAF6 IRF3 TRIM25 TLR3 MAVS PMC7269781__F3 BRCA pathway ATM ATF1 ATR BACH1 PMC10384352__F2 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections C4B_2 C1S PMC10384352__F3 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections TANK LILRB1 SYK IRF3 DKFZp686F0183 PMC5989766__F8 Impaired Akt signalling leads to iron accumulation APP PCBP1 HEL-S-44 PMC4191269__F1 Controller composed of the KDEL receptor (KDELR) and the Gq and Gs signaling pathways maintains the homeostasis of membrane transport at the Golgi complex ATF2 ATF1 CREB1 SRC ATF3 SP1 PMC7052944__F5 Regulatory effect of GPC3 on the WNT signaling pathway GPC3 GSK3B ARHA PMC5021733__F1 Negative regulators of Toll-like receptor signaling TLR5 LTA TLR4 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 SOCS1 MAL PMC5823541__F1 MTOR signaling pathway and the cell cycle pathway associated with lung adenocarcinoma as reported in NF1 TSC2 TSC1 ATM MDM2 STK11 MTOR PMC9218900__F3 Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation NLRP3 HMGB1 IRAK1 TRAF6 NFKBIZ IRAK4 REL GSDMD STAT3 PMC4370254__F1 Schematic depiction of sonic hedgehog (SHH) synthesis, secretion, and signaling HHIP BOC DISP1 SUFU PTCH1 GLI3 SHH SMO GAS1 PMC7696687__F1 Three-mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis pathways NMNAT1 NMNAT2 NMNAT3 PMC5354895__F14 Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGFB signaling CDH2 SP1 PMC8399569__F5 Plant Salicylic Acid Signalling Pathway Regulates the Infection of a Biotrophic Pathogen in Grasses Associated with an Epichloë Endophyte MYC COIL PMC11192764__F1 TGFB complex and TGFBR signaling pathways SMAD2 TGFBR1 PMC7696687__F2 Salvage (rescue) pathway remains a predominant pathway to meet NAD+ cellular requirements NAMPT PMC7727191__F3 Signaling pathways which CD44 regulates MMP2 MMP9 MDM2 CD44 SRC PMC5844972__F2 Three pathways of the unfolded protein response (UPR) ATF4 XBP1 GLS PMC6148250__F8 S100A10 and PAI-1 are regulated by Smad4-dependent TGFB1-mediated signaling and FOXC2-mediated PI3K signaling S100A10 SMAD2 TGFBR1 SMAD4 MTOR FOXC2 TGFB1 PMC3723114__F1 Canonical and noncanonical TGFB signaling systems activated during mammary tumorigenesis SMAD2 GRB2 SMAD4 ARHA PMC7349823__F7 Distinct mechanism of miR-210 in the regulation of mouse and cattle adipogenesis ZNF423 TCF4 PMC6558396__F1 Drosophila Hippo pathway Network PATJ ZYX PALS1 SCRIB WBP2 PMC8590693__F7 Hypothetical model illustrating multiple actions of NCT-58 on cancer stem-like properties, HER2 signaling, and trastuzumab resistance in HER2-positive breast cancer CD44 HSF1 PMC8431385__F2 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts IGF1R IKBKG CHUK BAD MAP2K4 BIRC5 MYC BCL2L1 CASP2 BCL2L11 CDKN2A IRF6 TNFSF6 DFFB APAF1 MDM2 CASP9 PRF1 IRF4 IRF2 BAX BAK1 IGF2 MAPK10 IRF3 CASP10 DIABLO BCL2L2 IKBKB TNFRSF25 NFKBIB LTA BBC3 TNFSF10 TNFRSF18 BCL2 MCL1 TNFRSF10B REL CYCS NFKBIE HRK CASP4 BOK PMC8431385__F3 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts POLD4 NOX3 POLD2 GPX1 MAPK14 MAOA NOX4 HMOX1 POLE2 POLE4 POLE GSTT2 POLE3 MSH6 HEL-S-44 XDH CYP1A1 JUNB MSH3 MSH2 UGT1A3 RPA1 FOS GCLC MAPK10 NFE2L2 CYBB POLD3 PMS2 RFC3 RFC4 RFC1 RFC2 GPX3 MGST1 TXN2 NFKB1 HEL-75 NOX5 PCNA TF PMC4542789__F3 Sub-network of genes regulated by E2F3, E2F4, and the E2F functional group MYB CASP6 CCNA2 FBXO5 TTK NOX4 DBF4 ATAD2 ORC2 CCND2 ECT2 CCNB1 PEG10 RAD51 MCM10 MSH2 ECE1 PTTG1 RBL1 CCNE2 MAD2L1 MCM7 TK1 MCM3 MCM5 MCM6 GAB2 CYC1 TP73 TYMS PCNA ZNF703 SKP2 PMC3429121__F2 Metabolic flux through the purine salvage pathway in L GDA GMPR APRT ASL PMC6592070__F1 CAMP/PKA pathway in S PGM2 RGS2 GAL PMC6592070__F2 CAMP/PKA pathway in C PGM2 GIP GAL PMC10572524__F7 DEGs in NOD/Toll-like receptor signaling pathway TLR5 NAIP CARD9 TLR4 STAT2 IRF9 IRF3 CXCL2 PMC11820663__F4 Macrophage polarization-related signaling pathway (by Figdraw) STAT1 TLR4 SMAD2 IRF3 MYD88 STAT3 PMC11592674__F6 Simulated microgravity effects on transcriptomic profile of bone marrow cell culture RUNX2 AMOT YAP1 MEIS1 DCHS1 AJUBA LATS1 LATS2 LIMD1 CTGF FAT4 TEAD2 CASP3 ALPL YWHAQ PATJ WTIP NF2 PALS1 SRC LPP FRMD6 PMC7709628__F1 Interplay between nutrient-sensing pathways potentially affecting health span FGF21 IGF1 INS MTOR PMC7709628__F2 Specific nutrients and dietary manipulations affecting insulin/insulin-like growth factor signaling (IIS) pathway FGF21 IGF1 INS MTOR INSR PMC11770381__F5 Neutrophils in CAC CXCL1 GPX4 MMP9 CD177 ROS1 STAT3 PMC6173473__F3 Crosstalk of bone cells within bone marrow regulates bone remodeling, adipogenesis, hematopoiesis, and angiogenesis LEP EPO MSC LEPR ADRB2 CXCL2 HIF1A PPARG PMC6592070__F3 Connections between the cAMP/PKA pathway and virulence-related functions in C CIRSR NRG1 ROS1 PMC5250648__F2 Ca2+ induces autophagy LRRK2 TFEB MCOLN3 MTOR PMC2861491__F1 Destruction of the Beta-catenin (Beta-Cat) destructor Axin APC TNKS2 PMC5357773__F5 FcGRIIIb initiates signaling pathways to the nucleus SRC SYK PMC8805398__F1 Rapamycin, Acarbose and 17Alpha-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation IL6 EIF4E TNF PMC6813288__F3 Mechanism of NFKB activation by PA TLR4 EIF2A GSK3B TRAF6 PMC6548160__F3 CSC signaling pathways which are regulated by BRCA proteins DHH IHH SHH NOTCH1 JAK1 BRCA1 PMC2575845__F1 RLR signaling pathway and its negative regulatory molecules TBK1 ISG15 CYLD NLRX1 TRAF3 TRAF6 IRF3 TRIM25 FADD RNF125 PMC2782488__F1 Cytokine signaling modules in inflammatory responses IL21R RORC SOCS3 IL7R RORA IL23R SOCS1 STAT3 FOXP3 PMC2782488__F3 Cytokine signaling modules in inflammatory responses CXCL1 SOCS3 CCL2 STAT3 PMC6122031__F9 Putative regulatory mechanisms of the FNM process MYB APC PMC2864712__F10 PAK4 regulates adhesion and migration via multiple signalling pathways HGF PAK4 ARHA PMC8931538__F9 JAM-A–tetraspanin–AvB5 integrin complex regulates contact inhibition of locomotion CD9 SRA1 CSK SRC RAC1 CD81 PMC8429033__F7 Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver CCND1 TYK2 STAT3 PMC3868890__F2 Main synaptic signaling mechanisms of endocannabinoid and hypocretinergic systems INA HEL-S-11 HCRTR1 HCRTR2 PMC1322299__F1 Tweaking Microtubules to Treat Scleroderma SMAD2 SMAD4 PMC5492089__F7 Schematic of canonical Hh pathway TH GLI3 SMO PMC4110715__F5 GeneGo graphic representation illustrates Transcription Androgen Receptor (AR) nuclear signaling EGF IGF1 GRIP1 MMP2 EGFR GRB2 MAPK1 NCOA1 HRAS STAT3 PMC3872778__F2 Similarities between NAA synthesis and citrate synthesis PDC CS MAL PMC3590129__F7 Differential Expression of miR-145 in Children with Kawasaki Disease SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA PMC5975367__F3 Targeting Autophagy in Cancer EGF ATM EGFR MDM2 PTEN MTOR JUN STAT3 PMC4222471__F2 RAS signaling pathway and genes mutated in juvenile myelomonocytic leukemia (in black) NF1 GRB2 RAF1 SOS1 MTOR CBL PMC4197205__F1 An IL-1-induced signaling pathway is mediated by K63-linked polyubiquitination of IRF1 TRAF6 CCL5 SPHK1 PMC7349538__F9 Biological model proposed for the yeast response to stress caused by inorganic acids MID1 HEL-75 GAS1 PMC2213034__F8 Our model for the mechanism of anti-CD63 inhibition FYN CD63 GAB2 LYN SYK PMC9331907__F3 Metabolism on Macrophage Polarization Under Different Disease Backgrounds IL1B PMC7488362__F2 Diagram depicting the mechanism of CR involving multiple signaling pathways ROCK2 ROCK1 SMAD2 EGFR APC CD44 HBEGF PTEN RHO MTOR GAB2 NOTCH1 SRC PMC5105878__F1 Schematic overview of the stepwise mechanisms involved in the development of immunoglobulin E (IgE)-mediated food allergy IL33 IL25 TSLP PMC8501036__F7 Proposed mechanistic pathway for the Fe2O3@KO2/zeolite catalyzed hydrogenation of CO2, highlighting the efficacy of our multifunctional system FER IMPACT COCH PMC10648679__F1 PSCs have emerged as a promising candidate for stem cells in PDAC IGF2 PMC7760557__F9 Melatonin in mitochondria of WT mice during cardiac aging NLRP3 INA MFN2 KEAP1 HMOX1 FADD AMT PMC6570498__F1 Endogenous H2S production, metabolism during methionine cycle PMC5946314__F1 Manipulating the PD-1 pathway to improve immunity APC ZAP70 PMC8752351__F3 CD36 in cardiovascular disease FOXO1 INSR CD36 PMC2853371__F9 CD28 costimulation, IL-2 signaling, and mTOR pathway regulate Otub1 and GRAIL expression, controlling proliferation in primary naive CD4 T cells PC APC MTOR PMC9616467__F8 Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens PDE4D ACACA PDE3A EGFR SMAD2 NRAS GCK EIF4EBP1 MTOR CCND3 CAV3 ACACB ROR2 MYOZ2 CAV2 RHOB PRKAB2 HEL-S-281 FASN ALDOB GDF5 GRB14 SOS2 IGF2 MAP3K7 ENO1 MAP2K2 ARHA FOXO1 TSC22D2 HEL-S-162eP CCNB3 IGF1 MUSK CCNB2 IGFBP1 SMURF2 HEL-S-42 NR1C2 IGFBP2 PRKAG2 RHOF PMC6668486__F2 NK cell transduction pathways involved in primary immunodeficiencies IL15 STAT1 STAT2 RELA RELB JAK1 DOCK2 IFNG IFIT1 PMC3248020__F9 Schematic representation of S100A7-mediated signaling that inhibits proliferation and motility in ERA+ breast cancer GSK3B S100A7 PMC7073073__F8 Representation of ATF6 acting on the TGFB–Smad pathway for induction of fibrosis genes SMAD2 SMURF2 TGFBR1 SMAD4 TMEPAI COL1A1 SMURF1 PMC8100607__F3 Reporters of Cancer Stem Cells as a Tool for Drug Discovery SOX2 HEL-S-53e FOXJ1 PMC8100607__F1 Reporters of Cancer Stem Cells as a Tool for Drug Discovery SOX2 ABCG2 PMC9378776__F2 Tryptophan in Chlamydia trachomatis persistence IL10 AHRR AHR CYP1B1 CYP1A1 ARG1 CYP1A2 PMC9414242__F1 Recent Advances in Nanoparticles-Based Platforms Targeting the PD-1/PD-L1 Pathway for Cancer Treatment NPS APC CD80 PMC5015042__F1 The mTORC1 amino acid–sensing pathway SLC38A9 CASTOR1 ARF1 RHEB PMC7019991__F2 Representative image describing the role of the NOTCH/JAG1 pathway in AML-MSCs of a model describing MSCs in human BM niche CD34 KITLG HES1 PMC11874752__F8 Schematic diagram displays the function of FLJ in CRPC ULK1 ULK2 PMC11635105__F4 STRING protein-protein interaction networks for the differentially methylated circadian pathways-related genes in HS PELO AGA CSTF3 PMC6563219__F3 Pathway visualization using downregulated differentially-expressed unigenes in Axon guidance, Regulation of actin cytoskeleton and Adherens junction FYN APC GSK3B SMAD4 SRC ARHA ROBO1 ROBO2 DCC CDC42 NCK1 PMC6563219__F4 Pathway visualization using downregulated differentially-expressed unigenes in cAMP signaling, Focal adhesion, Calcium signaling, Hippo signaling in fly and Notch signaling GLI3 GRB2 SCRIB RHO CRK PMC4111923__F2 An example of a CN: the EGF signaling pathway includes > 60 proteins and has several alternative pathways (from http://www.sabiosciences.com/pathwaycentral.php, where many other networks are also shown) MUC1 EGF RAB5A CSK EGFR RHO RAC1 STAT1 PAK1 ERBB2 GRB2 JAK1 STAT3 PMC7723514__F6 Pimozide in prolactinoma bromocriptine resistance PRLR CCND1 PRL PMC4060531__F3 Genetic Basis of Diffuse Large B Cell Lymphoma CARD11 BCL10 BCR CD40 MYD88 CD79B CD79A IRF4 BCL6 PMC7311368__F1 Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy IL33 CCL2 IL1B PMC6815593__F9 Schematic mechanism of matrine signaling pathway that inhibits cell growth and leads to cell death in HL-7702 cells CASP3 KEAP1 CDK2 CASP9 CASP8 PMC5336494__F2 Diagram of signaling pathways that control Notch expression in PC CYR61 ASPH EGFR PKD1 PMC8076903__F1 TRP Channels in Brain Tumors EGF TRPV4 HGF GFAP ATF3 MCU RHO RAC1 TRPM7 TRPV1 TRPM8 TRPC1 IGF1 TRPV2 TRPC6 GSC TRPM2 TRPA1 CERK MLSN2 STAT3 PMC4086465__F1 NKT-cell subsets: Promoters and protectors in inflammatory liver disease PDC APC PMC5336494__F1 Diagram of Notch signaling MMP9 CCND1 PMC6142530__F1 Novel agents and pathways under investigation in MDS HEL-S-26 MTOR PMC2856528__F1 The three complement activation pathways, converging to cleave C3 C4B_2 C1S PMC2963059__F2 Non-canonical Wnt pathways NLK DAAM1 BCL9 CDC42 PMC1998879__F2 Molecular pathway associated with neuronal migration VLDLR DAB1 NDEL1 PMC2963059__F1 Canonical Wnt/Beta-catenin pathway APC BCL9 PMC7601404__F1 Arginine biosynthesis NAGK NAGS ASL PMC9433876__F1 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response NF2 LATS1 LATS2 PMC9433876__F2 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response CXCL1 TLR4 CD163 opn CXCL12 CSF1 ARG1 IFNG PMC9433876__F3 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response LATS1 LATS2 PMC9433876__F4 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response TRAF6 LATS1 BACH1 TRIOBP PMC2704571__F2 Diagrammatic representation of hormone therapy-induced changes in gene expression in the dorsal raphe block EGF NGF MAP2K4 TRADD TNFAIP6 TGFBR1 MAP2K5 TNF FGFR2 FAF1 UBC KMO APAF1 TNFRSF21 TGFBR3 BDNF FADD BFAR DKFZp781O1323 PMC9116906__F2 Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets CDC37 CSA2 TRAF2 STAT3 PMC9423640__F2 Key genes pathway identification and potential drug design NKX2-2 HNF4A HEL-S-11 PAX4 PMC8818874__F5 Confirmation of inhibitingTLR4/MyD88/NFKB Signalling Pathway by Duhuo Jisheng Decoction on Osteoarthritis: A Network Pharmacology Approach-Integrated Experimental Study CHUK BAD CCNA2 MPO THBD MAPK8 RUNX2 COL3A1 BIRC5 ALOX12 MYC MAPK14 ALOX5 BCL2L1 CCL2 COL1A1 CHEK2 PLAT KDR MMP2 F3 CCNB1 LDLR CCND1 MAPK1 CDK4 CYP1A1 CASP8 HEL-S-117 HK2 SELE BAX MGAM FOS MAPK10 CXCL10 PTGES CXCL2 PRKCB CDKN1A SLC2A4 CDK2 HEL-75 PPARG PCNA CYCS STAT3 PMC6107850__F1 Overview of RNA-sensing pathway TBK1 NLRP3 TANK IRF7 DDX1 DHX36 IRF3 DHX15 TLR3 MAVS PMC8314463__F1 Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice RHO IPP RHEB HMGCR PMC8901705__F1 Key therapeutic targets in the pathogenesis of autoimmune diseases IL21R APC CTLA4 TNF IL23R GC CD40 TYK2 JAK3 CD80 JAK1 IL1B ICOS CD19 PMC8884367__F3 Inhibitory Immune Checkpoint Molecules and Exhaustion of T cells in COVID-19 FYN LCK LAG3 PMC8409023__F1 Targeting the tumor microenvironment in chronic lymphocytic leukemia ITK BTK BCR SYK CD19 PMC2929918__F1 Homocysteine metabolism in the liver HEL-S-61p PMC6021530__F1 Regulatory functions of oncogenic and tumor suppressor miRNAs on canonical Wnt signaling pathways in HCC NLK RUNX3 APC CD44 BMI1 DKK1 BCL9 WWOX PMC6996500__F7 Protein expression profile changes of lung tissue in patients with pulmonary hypertension DSC2 RYR2 DMD PMC12189131__F2 Metabolic effects of hydroxybenzoic acid derivatives on the coenzyme Q biosynthesis pathway COQ8A COQ3 COQ2 COQ9 COQ6 COQ5 PDSS1 COQ7 COQ8B PMC6996500__F8 Protein expression profile changes of lung tissue in patients with pulmonary hypertension PLN MYL2 MYL3 DMD MYH6 PMC9044593__F8 An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer NFYA ALDH2 PMC3759013__F1 Melanoma: New Insights and New Therapies ME1 KIT BRAF NRAS BCL2 PTEN MTOR AKT3 PMC3556327__F4 Cholesterol biosynthesis theme analysis ACADVL PMC7026586__F7 TP53BP1 and associated genes are downregulated in prostate cancer RNF168 RNF8 RIF1 BRCA1 TP53BP1 PMC2920482__F1 Detection of WNV and activation of IFNA/B genes and ISG according to the 2-step model TRAF3 IRF3 TYK2 IFNAR2 IFNAR1 PMC6209820__F5 Major pathways of cancer immunotherapy of Ganoderma in immune cells CD14 RCL1 F3 PMC9548376__F6 Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle CDK2 EGFR CHD8 CBL PMC6920895__F5 The metabolic network and key enzymes in Aurantiochytrium sp ACD PMC3877660__F1 An overview of EGFR and Wnt/Beta-catenin signaling EREG EGF NEU2 EGFR APC GSK3B LRP5 PTEN MTOR CRK GRB7 CBL PIM1 GRB2 CCND1 TGFA DACT1 PMC5589252__F6 Mapping the STK4/Hippo signaling network in prostate cancer cell AFP AMOT SMAD2 TGFBR1 GSK3B MYC SNAI2 SMAD4 LATS2 NKD1 NF2 CCND1 FZD10 PRKCI gdf7 LLGL2 WWC1 SOX2 YAP1 AREG SCRIB CTNNA1 FBXW11 PS1TP5BP1 DVL1 BIRC2 YWHAQ PATJ LEF1 WTIP RASSF1 BBC3 AXIN1 TP73 PPP2CA APC2 SMAD1 TGFB1 CRB1 PMC8745615__F2 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins USP9X FLT3 MTOR PMC8745615__F3 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins TRIB1 TRIB2 RFWD2 PMC9687758__F10 Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGFB1: Relevance to Pseudoexfoliation Glaucoma AFP SOX2 AMOT AREG SMAD2 APC PALS1 SMAD4 LATS1 SMAD1 PMC8156814__F5 Antitumor Activity of Nitazoxanide against Colon Cancers: Molecular Docking and Experimental Studies Based on Wnt/Beta-Catenin Signaling Inhibition CASP3 BAD APC CASP9 CCND1 RHO PMC6996500__F6 Protein expression profile changes of lung tissue in patients with pulmonary hypertension IGF1 MYL2 MYL3 SGCB DMD PMC5346542__F1 Metabolic reprogramming drives: (A) T-cell fate and function and (B) antitumor-immune response MYC CD80 CTLA4 HIF1A MTOR PMC11593441__F4 Signaling pathways regulating macrophage (Mφ) polarization IL10 CCR2 TRAF3 TRAF6 IRF3 MYD88 MTOR STAT1 TLR4 NOTCH1 ARG1 TIRAP STAT3 PMC10944288__F1 chemokine signaling pathway (hsa04062) as outlined in the KEGG database BAD PROC DOCK2 PMC10778864__F2 VEGF-VEGFR signaling pathway PIGF VEGFC VEGFD VEGFA VEGFB PMC8514798__F2 Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype SOCS3 DUT STAT3 PMC5309818__F3 Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions URAD FUT3 PMC11355545__F8 Schematic depicting the signaling pathway ROS/PARP/TRPM2 that causes SiNPs-induced lung inflammation in mice SQSTM1 TRPM2 PARG PMC10996061__F2 Impact of amotosalen/UVA treatment on phosphoproteome signaling and platelet pathways HEL-S-102 MAPKAPK2 SRC MAP3K5 MAP2K3 PMC11919857__F5 LncRNA-NEAT1 in cancer SULF1 SOX9 HMGA1 PMC6966712__F8 Hypothesis of XIST/TSIX/PD-L1 regulation MTOR PMC4420606__F8 TLR3/TRIF mainly regulates IL-32-mediated pro-inflammatory cytokine and IFNB secretion through activation of RIP-1 and TRAF family proteins TBK1 IRF7 TRAF1 TRAF3 IRF3 TRAF2 TLR3 PMC4792590__F4 Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner CASP3 BAD SMAD2 APC CASP9 SMAD4 MSH2 BAX PMC8003462__F1 Physiological functions of the various kinases included in the PKR/p38/RIPK1 pathway BACE1 RIPK1 EIF2A PMC2929244__F6 Defects in physiologically driven actin signaling at hippocampal synapses in Fmr1-KO mice SRC ARHA PSD PMC4956564__F2 NFKB-mediated regulation of inflammatory and immunosuppressive CD4+ T-cell lineages IL10 RORC TRADD RELB TRAF3 TRAF6 IL6 MYD88 MAP3K7IP1 FOXP3 BATF IFNG CARD11 CARD9 IL7 TBX21 BCL10 NFKB2 STAT4 IL2 GFI1 TRAF2 STAT3 PMC4696186__F2 Molecular mechanisms linking ciliogenesis and cell cycle regulation PLK1 KIF24 NEK2 MARK4 DAP CEP290 OFD1 NDE1 INPP5E NEK1 PMC7397409__F1 ERS and unfolded protein response (UPR) ATF4 PMC3340722__F2 TNF related apoptosis-inducing ligand and its receptors in ocular tumors FADD PMC6203150__F1 Regulation and downstream effects of the Akt signaling pathway TSC2 BAD TSC1 PTEN MTOR PMC9392983__F7 miR-212-3p attenuates neuroinflammation of rats with Alzheimer’s disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway BACE1 NLRP3 SP1 PMC3313452__F4 The noncanonical NFKB pathway TRAF3 RELB TRAF2 PMC8007363__F7 Smad3-NOX4-derived ROS-mediated p38MAPK/Akt signaling in TGFB1-induced ECM production of HBSMCs CS NOX4 PMC2789488__F3 Schema of major signaling pathways involved in renal development (for space and clarity, not all factors in each pathway shown) RET KCP GLI3 GRB2 SHH CCND1 GDNF SMO PMC10305525__F2 Three major H2S synthesis pathways are of enzymatic, non-enzymatic, and gut microbial origin DAO ETHE1 PMC2880522__F1 Results of a Pathway Studio® analysis of direct relationships between the components of the protein-bound fraction of renal cyst fluid FGA SERPINC1 HEL-S-62p PLG ALB AHSG SERPINA1 APOH KRT1 KRT10 PMC5730494__F6 Integration of signaling changes after the induction of BP1 FGFBP1 FGF2 RAC1 RAF1 CIT PMC11621238__F4 Mitochondrial dynamics and mitophagy in GBM cells MFN1 PINK1 MFN2 DISC1 BCL2L13 FAM72A KLF4 BNIP3 RAB32 PMC5388765__F1 An integrated network for phenylpropanoid regulation in the grape berry MYB VIT ERF PMC3194179__F4 Ingenuity Pathway Analysis identified NFKB as the Top Network signaling Hub where the shaded shapes indicate the candidate genes from the present study SPARC ANKRD1 NOD1 PACRG RASGRF2 KCNN2 KCNQ5 RRAS MAP2K5 SOX5 OPTN CTNND2 PMC3133912__F8 Bhlhb5 and the Notch signaling pathway FOXN4 DBX1 LFNG SHH OLIG2 PMC3194179__F2 Ingenuity Pathway Analysis identified ERK as the Top network signaling Hub where the shaded shapes indicate the candidate genes from the present study FER UCN3 MGAT3 AKAP6 CTNND1 PMC11825806__F7 Schematic diagram illustrating the effects of targeted activation of ErbB4 receptor on neuronal aging via ferroptosis inhibition GPX4 ERBB4 SLC7A11 PMC3194179__F3 Ingenuity Pathway Analysis identified MapK as second Top network signaling Hub where the shaded shapes indicate the candidate genes from current study TCF3 TNIK GUCY2C PAX5 GPRIN3 FOXN3 PSAP SRGAP3 ADCY5 TCF12 PITX1 ADAM19 PMC8529041__F7 Cancer Cell-Derived Exosomes Promote HCC Tumorigenesis Through Hedgehog Pathway SHH CCND1 PMC9492373__F9 Atractylenolide III Attenuates Apoptosis in H9c2 Cells by Inhibiting Endoplasmic Reticulum Stress through the GRP78/PERK/CHOP Signaling Pathway ELF2 ATF4 ATL3 PMC9201060__F7 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression WNT7A APC LRP5 SMAD4 AMHR2 LRP6 WIF1 SFRP5 AMH MMP2 F2 SMAD1 TF PMC4773560__F1 Mathematical model of adrenal steroidogenesis in NCI-H295R cells CORT CYP11A1 HSD3B2 HSD17B3 CYP21A2 PMC5412458__F2 Ubiquitylating enzymes and deubiquitylating enzymes (DUBs) govern the outcome of TGFB signaling USP15 SMURF2 SMAD6 TRAF6 TRAF4 PMC3417348__F8 Proposed role of ER calcium underlying early disruptions in synaptic homeostasis at the CA3–CA1 synapse in AD HEL-S-11 CA3 RYR2 PMC4090103__F2 Virulence Strategies of the Dominant USA300 Lineage of Community Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) ARC SPEG ARG1 PMC4272565__F6 Breast cancer pathway ATM BLM CDK3 ATR H2AX BRCA1 SMC1B AURKB PMC9201060__F1 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression TH AMH SMAD4 AMHR2 SMAD1 TF DKFZp781O1323 PMC8461076__F7 Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma KIT SPG20 ALK STOM NF2 KIN ARAF PMC5826318__F1 Host-secreated miRNAs regulate the gut microbiota that in turn affects the host via induction of specific miRNAs ABCG1 BCL2 PTEN ABCA1 STAT3 PMC4063414__F3 Phosphoglycerate mutase 1 (PGAM1) controls the levels of allosteric regulators 3-phosphoglycerate and 2-phosphoglycerate PSAT1 HEL-S-304 PSPH RPIA PGAM1 PMC10943178__F10 The effects of EC‐EVs in sepsis‐related ALI/ARDS VCAM1 ITGA4 CD80 PMC9635865__F1 Recent advances in postoperative pulmonary rehabilitation of patients with non-small cell lung cancer (Review) WNT3 MMP9 GSTM1 PIK3CA TERT PMC2433332__F3 T-cell polarizing factors TYK2 JAK3 JAK1 LAT STAT3 PMC5828008__F6 Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior NF1 GJB2 CLDN11 PMC11172800__F3 Significantly, DE genes (identified by KEGG) were involved in the bacterial invasion of epithelial cells signaling pathway during 8-week S PIK3CD HEL-S-28 DNM3 SHE WAS RHO ITGB1 ARPC5 CRK ARHG CAV2 CD2AP CTNNA2 CDC42 PMC7933196__F1 Berberine on diseases by regulating intestinal flora CD14 TLR4 MYD88 CD36 PMC5685854__F7 Pathway of VEGFR-2 (produced using the Pathway Builder Tool) VEGFC VEGFA SRC PXN PMC9139317__F5 Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma IDO1 KYNU KMO AFMID IDO2 PMC8138777__F1 Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease CHKA TMPRSS2 PMC3908331__F9 KEGG mapping for cell cycle pathway CDK2 CA14 MPL PCNA MAL PMC3868844__F6 Proposed signaling network involving mTORC2 and the p38 pathway STAT1 GYS2 EEF2K ADRA1B ATF1 MTOR DEPTOR FXYD1 XBP1 ATP11C PMC2988877__F2 DNA Damage Response: Making it safe to play with knives ATM BLM ATR PMC6460326__F1 HPV16 endocytosis and trafficking to multivesicular bodies CD151 CD63 PMC9167958__F7 Temperature and Growth Selection Effects on Proliferation, Differentiation, and Adipogenic Potential of Turkey Myogenic Satellite Cells Through Frizzled-7-Mediated Wnt Planar Cell Polarity Pathway FZD7 ARHA RAC1 PMC2988877__F3 The DNA Damage Response: Making it safe to play with knives BLM ATR PCNA PMC8534027__F2 Roles of Diacylglycerol Kinase A in Cancer Cell Proliferation and Apoptosis ARHA MTOR DGKA PMC5397843__F1 Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors DKFZp781B1423 CDKN1B VHL CDKN2A CCND3 CDKN1C CDK6 UBC RPL11 CREBBP EP300 CDKN1A CDK2 MDM2 CCND1 CDK4 PCNA SKP2 SUMO1 PMC3683050__F11 Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle NLK RAG1 GRB2 GCK ECSIT TNF TRAF2 JUN ERI1 PMC6921025__F1 Overview of PI3K-AKT signaling pathway RICTOR PTEN MTOR CDCA2 CRKL PMC4568771__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper APC LRP5 LRP6 BCL9 PMC2215765__F1 Schematic overview of the LPS TLR4 signaling pathway CD14 LBP IRF3 MYD88 TNF IL1B PMC7227439__F1 Role of metformin in VSMCs dysfunction RUNX2 PDK4 MTOR IFI16 SKP2 PMC4653031__F7 Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells IGF1R HIF1A IGFBP5 PMC8933845__F1 Immune Underpinnings of Barrett’s-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-Conspirators COX2 IL1A LIF TRIB3 IL6 IL1B PMC10866932__F7 SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification SALL4 METTL3 CD44 CCND1 PMC7563239__F1 Possible mode of action of matrikines on pulmonary arterial endothelial cells ARHA MTOR FADD PMC2258259__F1 Metabolic pathways involved in pyrimidine metabolism UCK2 DHFR UMPS DHODH PMC11817128__F6 Target protein involved in NGF-NTRK1 signal transduction controls key protein targets COX2 NGF NTRK1 GRB2 STAR PMC7376370__F8 Proposed mechanism and pathway of RUT in suppressing DSS-induced IBD in mice MAF HEL-S-44 HMOX1 PMC10487967__F2 CGAS–STING pathway in cell death, autophagy, and senescence TBK1 CGAS IRF3 MLKL PMC3688698__F3 The mTOR Pathway in Hepatic Malignancies EIF4E MTOR PMC10487967__F3 Different roles of the cGAS–STING pathway in host defense and various diseases CGAS COPA IRF3 JUN PMC7545119__F1 Diagram of substrate utilization and suspected pathways in BAT HMFN0839 SLC25A44 DGAT2 UCP1 MPC1 LPL MPC2 FASN CD36 PMC3764828__F5 Model depicting mitochondrial generation of H2O2 as a key modulator of TCR-mediated signal transduction PLCG1 APC LCK ZAP70 GRB2 LAT PMC6724002__F6 Schematic representation a proposed pathway for hispidin-induced Nrf2/ARE-mediated cytoprotective proteins GCLM GCLC NQO1 PMC7216777__F1 Metabolic processing of bioactive lipids and their role in host immune response to infection TES LTB PMC6591114__F1 Ze brafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis FECH UROD STEAP3 UROS CPOX FES ALAS2 PCBP1 PMC3026990__F5 Signaling networks associated with PPARD and inflammatory and invasive gene expression MPO FGF2 MMP9 EGFR CXCL2 SELL IKBKB CASP3 MMP12 MMP2 AGER NR1C2 CASP9 CXCL6 CDC42 PMC5696077__F3 Biosynthesis and Structure-Activity Relationships of the Lipid A Family of Glycolipids STAT1 NLRP3 IRF3 IFNAR2 MYD88 IFNAR1 TIRAP PMC9598565__F3 Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease CREBBP SET CAMK4 ATL1-beta PAWR CDK5 PPP1R18 CALY PPP1R1B PMC4970297__F6 Model summarizing the role of the HH signalling pathway and its primary transducer, GLI2, during mES cell cardiomyogenesis MESP1 SUFU NKX2-5 PTCH1 GLI3 TBX5 SMO SHF MEF2C GATA4 PMC5552241__F6 Proposed model of the Src/IGF-IR signaling axis present in both prostate cancer Exo and cells IGF1 SRC PMC8245769__F1 Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles NPAS2 PER2 PMC3713161__F7 Summary of the effects of increased dietary fat plus ethanol on the AMPK pathway and expression of enzymes involved in fatty acid synthesis HFE ACLY HEL-S-5 PMC4514171__F1 TLR diversity, ligands, and signaling TBK1 TLR7 TLR4 TLR9 IRAK1 TRAF6 MYD88 TLR1 TLR3 TIRAP PMC9630107__F3 Glucose metabolism proteins regulated by Src FYN F2 SRC HK2 HEL-S-162eP PMC3737583__F8 Working model for how ERA may modulate signaling by TLR-activated DCs PDC IMPACT IL23R IL1B PMC12114427__F2 Inducible expression pathway of Viperin IRF7 IRF3 IFNAR2 IFNAR1 IRF-1 MAVS PMC9419932__F4 Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair IGF1 ERG EGFR PTEN PMC9472457__F2 Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19 TBK1 CGAS IFNA21 IRF7 IRF9 IRF2BPL IRF3 MYD88 NOD2 NLRP7 TLR3 IFNG NLRP3 TLR8 TLR7 TLR4 DNASE2 TREX1 TMPRSS2 MAVS PMC5706812__F10 Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway EIF4E MTOR AKT3 PMC7686960__F6 Proposed model showing the suppressive mechanisms of Maackiain in RANKL‐activated NF‐KB and NFATc1 signalling pathways CTSK NFATC1 MMP9 ACP5 PMC9168169__F2 Advances in the study of RNA-binding proteins in diabetic complications PDX1 NLRP3 PDE3B MFN2 INSIG1 IGF2 DDX3X JUND MTOR DKFZp686F0183 IL1B PMC3436188__F8 Interaction between Ryk and Wnt signaling pathways LRP5 LRP6 ARHA RYK PMC3875403__F6 MDA-7 interferes with tumor promoting pathways GSK3B GSK3A PTEN PMC4230782__F9 The role of Pkp3 in cell–cell junction formation PKP2 PKP3 ARHA PMC8766833__F9 Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling EGFR BAX PMC8412840__F2 TGFB2 in cartilage development and diseases RUNX2 SMAD2 TIMP3 SMAD4 COL2A1 SMAD1 DKFZp781O1323 PMC9027975__F2 Interplay between Viruses and Host DNA Sensors IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC11920683__F10 Schematic showing genes upregulated by ibudilast treatment during NMDA retinal damage on scRNA‐seq analysis ULK1 TBC1D7 RHO EIF4E MTOR DEPTOR IRS1 RHEB MLST8 TTI1 RICTOR TSC1 IGF1 GRB2 GRB10 SGK1 PMC9027975__F5 Interplay between Viruses and Host DNA Sensors TBK1 IRF3 IFI16 PMC5345336__F4 Notch signaling pathway DLL4 JAG2 DLL3 PMC8125679__F2 More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond IGF1R FLNA SOX7 PMC3398238__F7 A ubiquitin-binding protein FAAP20 links RNF8-mediated ubiquitination to the Fanconi anemia DNA Repair network RNF8 FANCD2 FAAP24 MDC1 FANCM ATR PMC5769420__F4 Aurora kinase A and aurora kinase B interact with oncogenes to initiate tumorigenesis RALA BRCA1 AURKA PMC8820871__F4 Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure MYB BAD FRK CYC1 PTEN POLI MAL PMC4258904__F2 Plasmacytoid dendritic cell as the Swiss army knife of the immune system: Molecular regulation of their multifaceted functions TLR9 NAB2 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 LAG3 BTK TLR7 CD40 CD80 PMC4841296__F1 Main molecular mechanisms affected in malignant megakaryopoiesis and platelet function defects MYB MYH9 FLI1 GP9 NFE2 RUNX1 TUBB1 CCND1 TPO MYH10 MPL GATA1 PMC2610259__F1 Chronic colon colitis model MAF KEAP1 SFN NQO1 PMC7014825__F6 JNK1-dependent IL-17 and TGFB signaling CXCL1 SMAD2 ATF2 TGFBR1 TGFBR2 SMAD4 IL11 IL6 IL17RC PMC6466002__F2 Duck RIG-I-like receptor (RLR) family signaling pathway OASL IRF7 TRIM25 MAVS PMC4629002__F4 Networks predicted by Ingenuity Pathway Analysis in Cmah-null mice ALAS2 AQP8 GCK STAT5B ACOX1 THRSP G0S2 HEL-S-94n LPL HEL-S-44 CUX2 BTG2 MEDAG NT5E APOE AIP ANGPTL4 HAMP AACS IL8RB ELOVL6 HLA-B HEL-S-22 LEP SERPINA12 DDX3Y GNAT1 CRELD2 H6PD CEND1 IVNS1ABP IGFBP2 MED13 CSRP3 HEL107 HEL-S-72p EHHADH ASL ITCH RBP1 IGF1R SPON2 HSP90AB1 HEL-S-134P TFRC RHO HBA2 AHR RGS16 SGK1 PER2 RORC INPPL1 EGR1 USP2 NAT8 FKBP5 RXRG FBXO2 FMO5 HSF2 NR1C1 HSD3B7 IKBKB LIPE ASNS PARP2 PPARG VAMP7 STIM1 PMC9292703__F1 Tryptophan‐derived serotonin‐kynurenine balance in immune activation and intestinal inflammation IDO1 KMO AANAT PMC10931026__F1 The polyamine synthesis pathway SMOX SRM PAOX AMD1 SMS PMC8866876__F4 Nrf2 Pathway in Liver Diseases KEAP1 SFN SQSTM1 SNX10 GSTM3 CYP2E1 NQO1 PMC8866876__F1 Nrf2 Pathway in Liver Diseases KEAP1 GSK3B RBX1 PMC6116371__F3 CircRNA and cancer-associated signaling pathways SETDB1 EGFR STAT3 PMC4620040__F1 Inflammatory bowel disease (IBD) as a multifactorial disorder CD1D CCR6 TNFRSF6B NOD2 XBP1 NLRP3 TLR4 IL10 TNLG1B ATG16L1 LRRK2 ITLN1 IRGM PTGER4 SLC22A5 IL23R TSLP IL12B DLG5 CARD9 ARPC2 DMBT1 TNFAIP3 IL18RAP STAT3 PMC8674839__F2 Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits TRPC1 RYR3 RYR2 ORAI1 STIM1 PMC4191659__F2 Receptor “hijacking” by malignant glioma cells: a tactic for tumor progression EGF EGFR CXCL8 SRC BCL2 STAT3 PMC4470795__F1 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis ALDOB HEL-S-49 PC ENO1 ENO2 HEL-S-133P HEL-S-281 HEL-S-68p HEL-S-162eP PMC9272348__F3 Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease HEL-S-44 ACHE PMC3640280__F5 A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance HEL-S-62p IGF1 MTOR HEL-S-5 PMC7380956__F1 Accessory pathways of glucose metabolism: DAG1 FKRP PHGDH PMC3429879__F1 Therapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer TK1 PNP PMC3641842__F1 The complement system HEL-S-62p C4B_2 CD46 MASP1 MBP C4A CR1 C9 VTN C7 C6 SERPING1 CD55 PMC5887227__F9 ScRNA-seq profiling on progenitor cells and hPSCs AFP PTN NODAL TBX3 SNAI2 HAND1 PAX3 HEL-S-78p KDR ARID5B TFAP2A ZIC2 PRRX1 FOS SALL1 CD34 PDPN ID1 PLN HOXA1 TFAP2C ECSCR OTX2 CDX1 MEF2C GDF3 CD24 PMC6345546__F1 Mechanisms of translation initiation currently known ELF3 EIF3D EIF4E PMC8268428__F2 Janus Face of IL-33 Signaling in Tumor Development and Immune Escape IRAK1 CDK2 AREG SIGIRR IL33 TRAF6 IRAK4 MYD88 BAX PMC8650690__F6 Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism IGF1 SMAD2 MTOR PMC4011666__F7 Calcineurin Signaling Regulates Neural Induction Through Antagonizing the BMP Pathway SMAD4 SMAD1 DKFZp781O1323 PMC9570443__F1 Pyroptosis and Insulin Resistance in Metabolic Organs NLRP3 GSDMD DFNA5 PMC3502876__F1 Reactive oxygen species-mediated autophagy regulation HMGB1 ULK1 ATG12 PTEN ULK2 MTOR DEPTOR DKFZp686F0183 RHEB MLST8 HEL-S-2a TSC1 ATM UVRAG BNIP3 PMC7875152__F2 Genetic causes of PH BMPR2 ACVRL1 BMP10 AQP1 ATP13A3 ENG KCNK3 ABCC8 TBX4 SOX17 PMC8833412__F1 New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications SDHC CS MAML3 VHL EIF4E HRAS EGLN1 MDH2 TMEM127 HEL-S-26 NF1 RET FGFR1 MAX APAF1 FH MERTK EGLN2 SDHD SDHAF2 SDHA CSDE1 SDHB PMC3518467__F1 Fast, Potent Pharmacological Expansion of Endogenous Hes3+/Sox2+ Cells in the Adult Mouse and Rat Hippocampus HES3 GFAP MTOR STAT3 PMC3731517__F6 Hepatic cholesterol synthesis and catabolism enzymes, uptake receptors, BA transport systems, phase II detoxification enzymes, and nuclear receptors investigated in this study CYP27A1 CYP8B1 SULT2A1 LDLR CYP7B1 UGT1A1 CYP7A1 PMC6038278__F1 Dysregulated genes and associated miRNAs in the KEGG TGFBeta-signaling pathway BAMBI FST NODAL TGFBR1 SMAD4 SKP1 ARHA SP1 TNF RBX1 INHBA IFNG PMC4264883__F4 Downstream Targets of Lmo4 Are Modulated by Cisplatin in the Inner Ear of Wistar Rats STAT1 NOX3 LMO4 BCL2 TYK2 JAK1 BRCA1 STAT3 PMC6038278__F2 MiRNA-mRNA associations involving genes in the KEGG TGFBeta-Signaling Pathway by location of action: extracellular factors (a), membrane receptors (b), and nuclear factors (c) TGIF2 MYC E2F5 THBS1 TFDP1 RBL1 PMC2733081__F4 MAPK Signaling Cascade is a Central Hub in the Regulation of Cell Cycle, Apoptosis and Cytoskeleton Remodeling by Tripeptidyl-Peptidase II E2F4 ITGA6 MYC INHBE PMC5137308__F7 Molecular mechanism for neurogenesis activated by 5-HT4 receptors by MOS KIF26A RET MOS GRB2 GDNF RHO PTEN SPRY2 CDC42 PMC9305276__F4 Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation NLRP3 IRF3 IL1B MAVS PMC3531289__F1 Chapter 3: Small Molecules and Disease AEN PTER PMC8866876__F5 Nrf2 Pathway in Liver Diseases KEAP1 SFN CCL4 LHB CYP2E1 PMC6321527__F5 Hypothesized mechanism of S5-induced death of human melanoma A375 cells EGFR CCNB1 PMC5141361__F3 Details of the PMF network model showing deregulated miRNAs and genes that participates to specific connected pathways, linked in turn to biological processes and functions germane to the disease CREBBP ANGPT4 MISP ARHGEF12 ARHA PTEN MTOR PMC3159301__F1 Pathways involved in platelet hyperreactivity in DM patients and therapeutic targets VASP COX1 GC IRS1 PMC8009526__F1 Signaling networks in inflammatory pathways and risk for suicidal behavior IL10 NFKB2 SI FOS NFKB1 IL6ST TNF IL6R JUN IL1B CEBPB STAT3 PMC7487062__F4 MDA-9/Syntenin/SDCBP: New insights into a unique multifunctional scaffold protein HEL-S-28 SMAD2 MMP9 TGFBR1 EGFR GSK3B VEGFA ARHA MMP2 SRC IGFBP2 STAT3 CDC42 PMC4607655__F3 Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During a Preterm Infant Gut Colonization Case TIAM1 VASP STX4A CASK CRB3 ARHA PTEN HEL114 CGN RAB13 PMC5283709__F3 A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 RET FRK TERT PMC3789261__F3 Pathways impinging specifically on glucose-mediated F-actin remodeling in the B cell PAK1 VAMP2 CDC42 PMC2858906__F1 Main steps and key regulators in blood and lymphatic vasculature development ETV2 SOX18 PROX1 PMC7920857__F8 Mechanism graph of the regulatory network and function of SIRT1 in aging of HEMECsSIRT1 restrains cell aging through GIRDIN phosphorylation via Akt signaling pathway IGF1 SIRT1 PMC11629350__F6 Neural graph network displaying the six signaling pathways that were detected as significantly regulated, along with the genes within these pathways that were significantly affected by mechanical loading (0 ARHGEF18 WHAMM AQP7 SLC2A4 CACNB1 NCOR2 PMC8650620__F2 In Sickness and in Health: The Oxygen Reactive Species and the Bone RUNX2 NOX4 PTH PMC8426635__F7 Tricin Biosynthesis and Bioengineering CAD PRX PMC5480057__F4 Extended regulatory network to describe Nanog multistable dynamics in serum/LIF FGF4 SOX2 ESRRB KLF4 PMC6539579__F5 Roles of c-Myc in colorectal cancer (CRC) organoids CEMIP PMC6539579__F3 Regulation of Wnt/Beta-catenin/c-Myc signaling pathway APC CCND1 TCF4 PMC5354887__F7 Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells BRAF IRS1 PMC11783064__F3 Molecular-signalling pathways activated by methamphetamine contribute to cardiotoxicity TAAR1 KEAP1 BCL2 FIS1 BAX PMC12065022__F7 Working model for the mechanism of quercetin on HCC P4HA2 MTOR BAX PMC9672399__F5 Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins SPARC F10 HAPLN1 FBLN2 NPM1 TNFAIP6 APOD PRELP SERPING1 B2M APOE RELN TUBB CTSO VCAN SRPX2 RARRES2 PTX3 APOB MMP14 IGFBP4 LOXL1 ACLY HABP2 HEL-S-62p OLFML2B LOXL3 C4B_2 LOXL4 HEL-S-101 TPM3 C4A NOTCH3 CLU ITIH2 GREM1 CFD LDLR COL1A2 APP SFRP1 MFAP2 FNDC1 FASN CSPG4 IL6 NPTX1 LTBP1 NID2 HP PTPRE CSF1 PMC6371621__F1 The mechanisms of microRNA biogenesis and its regulation of gene expression AGO1 AGO2 DGCR8 AGO4 DROSHA RAN PMC7554303__F2 Various cell fates upon Mycobacterium tuberculosis infection TRADD IL1B FADD CD36 PMC8106603__F2 Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma MFN1 MFN2 EIF2A XBP1 PMC10539095__F2 Molecular Basis of Wnt/Beta-Catenin Signaling Pathways in Neurodegenerative Diseases DAAM1 F2 RYK RHO PMC8955937__F9 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders CS HIF1A HEL-S-133P HK2 PMC8700745__F3 Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario VIT SST PC SLC26A7 PTH PTHLH PMC3607103__F3 Recognition of nucleic acids by innate immune cells triggers cytokine production TLR7 TLR9 BCR IRF7 DDX41 MYD88 AIM2 MAVS PMC3284544__F4 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis CD14 TLR4 LBP TRAF6 MYD88 MAP3K7IP1 TIRAP PMC3284544__F5 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis TRADD DIABLO TRAF2 HTRA2 FADD PMC8941124__F7 Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells ULK1 ATM DRAM1 MYC BCL2 BMI1 PACS1 BAX PMC8572597__F7 Exploring the Effect of Jiawei Buguzhi Pills on TGF-Beta-Smad Pathway in Postmenopausal Osteoporosis Based on Integrated Pharmacological Strategy BAMBI FST NODAL SMAD2 SMURF2 THSD4 SMAD4 RHO TNF SMURF1 PMC9189138__F2 Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT CXCR4 EGFR LYN RHO CDH2 EPHA2 DDR2 TGFB1 SOX4 PMC3284544__F6 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis ISG15 RET TANK IRF7 IFNE UNK IRF3 MAVS PMC6167446__F1 Pathogenic roles of NLRP3 inflammasome in liver diseases NLRP3 TLR7 TLR4 TXNIP IL1B PMC10926276__F5 Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRB/PI3K/AKT pathway SUMO2 HAL DDX47 STX2 MOGAT2 ZBP1 SCD RTCA GBP2 HGS MAPK1 HSD3B2 CAD GPNMB GTF2B ROCK2 SNCA SAA4 SCAI CDK5 GMFB CYP7B1 ENG UBE2B NECTIN2 MPG ITGAM NUP58 SDC4 ASNS HEL-S-273 TXNIP PMC3849943__F2 Network of the interactions of the miRNAs and their target genes (experimental observed or highly predicted) SOCS3 DPP4 TGFBR1 MYC LPAR2 BCL2L1 CCL2 TNFSF13 TNFRSF9 PIM1 IL18 TLR4 PLXND1 KLRK1 CDH2 F11R SCG2 TNLG1B SCARB1 FOS PTGS2 FTL TIGIT ST8SIA1 MMP14 ULBP2 NRP1 PTPRO TRIB1 CD40 IL2RA TNFRSF10B CSF1 TNFAIP3 PNP COL4A1 PMC3513881__F3 Proposed three pathways for the mechanism of nicotinic acetylcholine receptor (nAChR)-mediated survival signal transduction FYN STAT3 PMC4545436__F1 Signaling pathways involved in CSCs SAG APC PTCH1 GSK3B SHH SMO PMC4423147__F8 The Nodal signaling pathway during establishment of the LR asymmetry in amphioxus NODAL FOXQ1 LHX3 GDF1 DKK1 DKK2 DKK4 GDF3 PMC3297581__F6 Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line FLI1 CEBPE ELK3 RUNX1 RUNX2 ERG CEBPA NR1C2 RORA REL JUN IRF-1 HLF STAT3 PMC10540075__F8 Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights NAMPT NADK NMNAT3 SLC22A3 NRK SLC36A4 SLC12A8 SLC7A5 NAPRT HEL-S-90n SLC5A8 NMNAT1 KYNU KMO NMNAT2 PMC7595283__F1 Some like it hot: Candida activation of inflammasomes NLRP3 CARD9 NLRC4 EGFR SYK IL1B PMC6795182__F1 Cluster-1, cluster-2, and cluster-3, with molecular-targeted therapeutic options EGF MAML3 EGFR VHL IRS1 HDAC1 EGLN1 MDH2 TMEM127 TSC2 NF1 TSC1 MAX FH EGLN2 CSDE1 PMC4599277__F7 Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-Beta-catenin signaling axis in a microRNA-34a dependent manner APC WNT1 GSK3B STAT3 PMC6059011__F1 EV Biogenesis and Interaction With Recipient CellsExosome formation starts with endocytosis, a process in which the cell membrane is pinched inward and captures bioactive molecules, resulting in the formation of the endosome TSG101 RAB27A RAB31 RAB27B RAB7A ARF6 PMC8027612__F8 Protective effect of SAA on vascular permeability via inhibition of VEGFA-Src-MMP signaling pathway activation during acute ischemic stroke VEGFA PMC4417677__F1 Cartoon illustration of the physiological roles and therapeutic implications of OCT1, SLC13A5 and ZnT8 in glucose metabolism, lipogenesis and insulin pathway OGDH TG SLC13A5 PMC8306901__F5 Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma NF1 KIT PDK2 NRAS MDM2 PTEN CTLA4 MTOR CBL PMC5416953__F5 Working model of the role of LXR in Fgf21 gene regulation in mouse liver during fasting HDAC3 POLL DUX1 RORA POLI PMC8215544__F4 Neddylation Regulates Macrophages and Implications for Cancer Therapy WEE1 ORC1L CDT1 BAX PMC4658613__F6 Insulin-like growth factor-1 signaling with regard to Helicobacter pylori associated glucose dysregulation IGF1R IGF1 IRS1 PMC11979393__F1 The apoptosis signaling pathway TRADD BCL2 TRAF2 FADD BAX PMC10181312__F2 Circadian clock system involved in regulating photoperiodic flowering in Arabidopsis, soybean, and rice RFT1 PRR9 ELF3 PRR5 EHD1 PRR7 RFWD2 PMC11853215__F7 Proposed simplified signaling pathway elucidating the mechanism underlying the amelioration of steatosis induced by Exendin-4 ACADL FOXM1 CXCR4 CDC2 MTTP GLP1R NR1H2 PMC4609261__F1A Mapping the pathways of resistance to targeted therapies HRAS MTOR PMC5448109__F6 Simplified models of ribonucleotide excision repair in Eukarya (A), Archaea (B), and Bacteria (C) FEN1 POLL PCNA POLI PMC8106186__F1 Signalling pathways involved in CM, UM and MM oncogenesis, and regulation of HIF under hypoxia NF1 KIT BRAF CXCR4 NRAS PTEN MTOR PMC1913098__F1 Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control SOCS3 LIF STAT3 PMC4470795__F4 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis GLS2 GSTM3 HEL-S-21 PMC3812980__F6 Proposed schema of how the BMP signaling axis limits neurogenic muscle wasting SMAD4 SMAD1 DKFZp781O1323 PMC8293747__F1 Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review NLRP3 IL1B GSDMD PMC8858079__F1 IGF cascade IGF1R GRB2 CCND1 BCL2 MTOR IRS1 IGF2R PMC10964526__F8 Potential pathways of exercise training to improve pulmonary function USP44 MTOR CCL3 TRPM8 FOXP3 PMC4506786__F4 Linear ubiquitination signals in adaptive immune responses RIPK1 TRADD TRAF5 CYLD SHARPIN TNF OTULIN TRAF2 FADD PMC11849352__F1 TLR3 signaling pathway TRAF3 TRAF6 IRF3 TLR3 PMC11103046__F1 Cardioprotective Mechanisms of SGLT2 Inhibitors Against Cancer Treatment–Induced CardiotoxicitySodium-glucose cotransporter-2 (SGLT2) inhibitors protect against cardiovascular toxicity induced by anticancer drugs via multiple mechanisms NLRP3 ATF4 MTOR NQO1 PMC4506786__F1 Linear ubiquitination signals in adaptive immune responses TRADD TRAF5 CYLD SHARPIN TNF OTULIN TRAF2 PMC9708627__F2 Interferon in systemic lupus erythematosus—A halfway between monogenic autoinflammatory and autoimmune disease PDC TREX1 PMC5563293__F2 Schematic presentation of the fusion-activated Ca2+ entry (FACE) CD9 ADA CAD ORAI1 PMC11103046__F2 The Anticancer Effects of SGLT2iSGLT2 inhibitors (SGLT2i) inhibit glucose uptake by inhibiting SGLTs (SGLT-1 and SGLT-2) and glucose transporters (GLUTs) TIMP1 FOXA1 YAP1 EGFR SHH MTOR PMC3378547__F5 Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing SEL1L GLT8D2 PDIA4 WFS1 PDIA5 HYOU1 XBP1 SSR2 RPN1 SIL1 SRPRB ALG2 STT3A EDEM1 DNAJB11 ATF4 PPIB VCP GMPPB SEC61A1 PMC7554303__F3 Immunometabolic and bioenergetic changes in a macrophage infected with Mycobacterium tuberculosis COX2 MFF IL13 CXCL10 CXCL9 JAK3 MYD88 JAK1 IL4 CAD GATA3 CD36 PMC7226825__F2 Anti-inflammatory roles of GFLs and their receptors following air pollution, allergy, bacteria or virus infections IL10 CDA MPO IL6 ARTN NRTN RET IL16 IL22 GDNF IL4 TGFB1 GFRA2 PMC3683875__F1 Nucleotide excision repair (NER) pathway XPC ERCC1 XPA PCNA CPD PMC3670291__F2 Roles of STATs signaling in cardiovascular diseases GRB2 SRC JAK1 STAT3 PMC8145016__F2 Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients FGF23 NR1i1 FGFR4 PMC3008633__F1 Examples of reaction–diffusion processes in muscle TNC CS PC PMC7555983__F6 MiRNAs, their related gene targets and cellular pathways likely involved in MFS aortopathy CCNA2 APC PMC7290605__F4 Schematic diagram represent the Putative mechanism of HPV in breast carcinogenesis COX2 NFX1 SRC BRCA1 PMC7659352__F13 Co-treatment with coffee decoction and tamoxifen markedly induces apoptosis by activating p53 in MCF-7 cells PGR TFF1 GREB1 HEL-S-130P BAX PMC6387651__F6 Proposed signaling pathways that regulate LSEC phenotype and crosstalk between LSECs and HSCs in normal and fibrotic liver EGF CD47 ADAMTS13 EGFR HBEGF CD36 PMC4082184__F2 Turning Off AKT: PHLPP as a Drug Target PTEN IRS1 PMC3911663__F5 Summary model for rAdV DNA sensing CGAS TLR9 IRF7 DDX41 IRF3 MYD88 AIM2 PMC9612852__F2 Intracellular checkpoint of IL-15 signaling in human or murine NK cells GAB2 GRB2 IL15RA JAK3 JAK1 MTOR XBP1 FOXO1 STAT3 PMC8704600__F1 Crosstalk between Statins and Cancer Prevention and Therapy: An Update EGFR BCL2 RHO BAX PMC3727904__F2 PATHWAYS IN MICROBE-INDUCED OBESITY CD14 TLR5 TLR4 TLR9 PYY MYD88 IL1B LTBR IFNG PMC4777532__F3 Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance GAD2 DAO ALDH3A2 MTHFD2 NF1 FYN NOS2 RELN TAF10 ACTN2 DLD GAD1 MTR VAMP2 OGDHL DHFR AMT GLS MTHFD1L HYI PIG59 HEL-S-182mP TBL1X INS PPY Em:AP000351.3 TXNDC12 ACSM2B ABHD14A CACNG4 NAF1 CARNS1 GATF-C ARG2 GLYATL2 HEL-S-8a AGXT HEL-S-70p MED1 CAD GAL ARG1 PIPOX SNAP25 ASPA NAGS FOXA2 ASNS TYMS SPTLC2 GLDC HEL-S-51e PMC9314626__F2 Metabolic dynamics instruct CD8+ T‐cell differentiation and functions TSC2 TSC1 CPT1A SLC7A1 APC MYC CD80 MTOR OPA1 PMC7865543__F3 Signaling pathways involved in regulation of and therapeutic avenues for targeting the LOX family LOXL2 BMP1 SRC LOXL1 PMC10473154__F1 Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease MFN1 SNCA PINK1 MFN2 LRRK2 NRF1 TFAM OPA1 PMC7263916__F4 Avian leukosis virus subgroup J and reticuloendotheliosis virus coinfection induced TRIM62 regulation of the actin cytoskeleton F2 APC INS ABI2 DOCK1 RHO HEL114 TG PXN PMC8949402__F2 Immune Escape Mechanism and Vaccine Research Progress of African Swine Fever Virus CGAS TLR3 PMC7187988__F2 Hormonal control of adipocyte lipolysis PDE3B ABHD5 PLIN1 FAP GC ABHD15 IRS1 PNPLA2 PMC6780086__F6 Transcriptional profiling of enzymes involved in type II fatty acid synthesis (FASII), glycerolipid synthesis in plastid (GLSp) and cytosol glycolysis (GLSc), and beta-oxidation PC GAL TG PMC5777172__F2 Regulation of hepatic glucose metabolism in health and disease GCGR PDE3B GCK INSR PMC5729931__F5 Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon like peptide-1 in the paraventricular hypothalamus CRH NTS PSD GLP1R PMC5431987__F5 Ingenuity Pathway Analysis cancer network from RNA-Seq breast cancer samples CASP3 NEDD9 ZEB2 EGFR NRG1 HCAR2 PRNP BCL6 PMC8369345__F1 Role for Frizzled and Their Post-Translational Modifications in the Mammalian Central Nervous System APC GSK3B LRP6 RYK RHO PMC12106438__F2 Molecular mechanisms of intracellular lactate production and export PDC HEL-S-133P GLS PMC12106438__F3 Effects and mechanisms of lactate on macrophage polarization HMGB1 MPC1 HIF1A ARG1 HK2 GPR65 PMC3379693__F1 Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut TBK1 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TIRAP PMC7187988__F5 Adipocyte lipolysis is implicated in disease such as diabetes, fatty liver disease and cancer G0S2 PC PLIN1 IL1B PMC8012622__F5 Formation pathway of cytoskeleton structure by F-actin ARHA RHO RAC1 CDC42 PMC5356911__F1 Extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma UNK TRAF6 MAP3K7IP1 TAB3 PMC5226619__F3 Inflammasome: an emerging therapeutic oncotarget for cancer prevention STAT1 TNF STAT3 PMC8093981__F1 14‐3‐3 proteins in cell signalling pathways and virus infection TSC2 BAD PMC8093981__F2 14‐3‐3 proteins in cell signalling pathways and virus infection TLR4 IRF7 IRF3 TLR1 TRIM25 TIRAP PMC7163447__F9 Proposed model for the role of mitochondrial biogenesis process in developmental fluoride neurotoxicity and protective action of RSV NRF1 TFAM SIRT1 PMC2784025__F8 Proposed model of the underlying mechanism by which NeuroD6 may bridge neuronal differentiation to survival CASP3 NEUROD6 APAF1 CASP9 PMC5479446__F1 Schematic view of UPR response in mammals ATF4 EIF2A TRAF2 XBP1 PMC10534925__F3 Epidermal Growth Factor Receptor-Targeted Neoantigen Peptide Vaccination for the Treatment of Non-Small Cell Lung Cancer and Glioblastoma CD80 PMC7736222__F2 PGC-to-ProSG-to-SG transition KIT ID4 CD82 ETV4 LHX1 CDKN2A UTF1 PALLD NR1B3 DAZL PGC STRA8 NANOS3 PIWIL4 CDC2 ETV5 POU5F1 MKI67 DNMT3L ELMO1 PMC11522757__F1 Regulated cell death (RCD) pathways implicated in pathological cardiac hypertrophy NLRP3 GPX4 RIPK3 ULK2 LPO TNF MTOR MLKL GSDMD BAX PMC10571577__F3 Acquired mechanisms of resistance to MET-Is EGF BRAF EGFR NRG1 PMC10571577__F1 HGF/c-MET signaling pathway HGF EGFR GRB2 CD44 MST1R MTOR ROR1 STAT3 PMC9228484__F1 Virus–Host Interplay in Junín Mammarenavirus Infection HDC PMC3857020__F10 Proposed functions of Spry1 and Spry2 in regulation of eyelid closure FGF10 SHH CCND1 SPRY1 FGFR2 SPRY2 CCND2 PMC9228484__F2 Virus–Host Interplay in Junín Mammarenavirus Infection TSG101 VPS4B IMPDH2 VPS4A ARF1 PMC7910064__F5 Schematic figures of metabolic alterations in HCC HEL-S-26 TG NR1C1 CD36 PMC6498733__F1 Beta-adrenergic signaling pathway in prostatic cancer BAD BCL2 ENO2 PAK4 HDAC2 ARHA PMC8190251__F3 Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock NAMPT NMNAT1 NMNAT2 NMNAT3 SIRT1 PMC8105194__F1 Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors SAG DAGLA FAAH PMC12167312__F1 Developmental neurotoxicity induced by anesthetics targeting GABAARs TLR4 TRAF6 MYD88 MTOR BDNF BACH1 BAX PMC6997384__F1 Erythropoietin and its derivatives: from tissue protection to immune regulation MFGE8 CXCL1 CCL11 EPO TPR CCL2 CEBPB JAK3 MERTK JAK1 ARG1 STAT3 CCL3 CD36 PMC12167312__F2 Effects of anesthetics targeting GABAARs on different neuronal populations TNF BDNF PMC12167312__F3 Neuroprotective mechanisms of NAS TLR7 TLR4 TRAF6 MYD88 TIRAP GPER BAX PMC5618308__F1A Unlocking the NFKB Conundrum: Embracing Complexity to Achieve Specificity TRADD TRAF5 RELA TRAF6 IRAK4 MYD88 MAP3K7IP1 TRAF2 TAB3 PMC6997384__F2 Erythropoietin and its derivatives: from tissue protection to immune regulation TLR4 EPO TLR9 IRAK1 TRAF6 TPR MYD88 IL1B SOCS1 STAT3 PMC6997384__F3 Erythropoietin and its derivatives: from tissue protection to immune regulation EPO APC GRB2 TPR IL2RA JAK1 POR IL2RB PMC2997007__F5 Candidate master switch molecules and signaling pathways involved in LPS-induced inflammatory response of monocyte THP-1 cells IL10 CD14 CCR5 EGR1 ITGB3 ATF2 ITGA4 TNFRSF11B ITGA2 STAT1 VCAM1 RELA KITLG BCL2 SYK SELP TNFRSF10B SP1 OSM IL1B TNFRSF10C SELE PMC2997007__F6 Identification of putative signaling regulators for immune-modification MPO TNFRSF11B ITGA2 STAT1 NGFR CXCR4 RELA KITLG BCL2 YY1 SELP SP1 TNFRSF10C PMC9485555__F8 Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease BAD BCL2 CD74 ACOX1 CD36 PMC7365992__F3 Extrinsic pathway involves transmembrane receptor mediated interactions FADD PMC7365992__F4 Apoptosis and genes involved in oral cancer - a comprehensive review BAD AVEN CAD DIABLO PMC8493690__F5 Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway YAP1 LATS1 LATS2 PMC11591633__F5 Pharmacological modulation of NCC function in the DCT CASR KLHL3 WNK1 OSR1 WNK4 SGK1 PMC11591633__F3 Post-translational modifications regulating NCC activity in the DCT KLHL3 WNK1 OSR1 CAB39 WNK4 PMC11591633__F4 Physiological stimuli that modulate NCC activity CORT KLHL3 WNK1 AVP INS OSR1 WNK4 SGK1 PMC11598704__F3 Role of deubiquitinating enzymes on the cell cycle in GC USP12 OTUD7B USP9X USP20 USP35 LATS1 USP37 USP49 USP29 OTUD5 LATS2 PMC4628672__F3 Pathways analysis of the proteins listed in by means of the Ingenuity software HEL-S-67p APAF1 CASP9 BCL2 PMC2954727__F1 Working model of the effects of E2 on cell migration NODAL EGFR SRC ARHA VAV2 PMC6942871__F6 The main targets of miR-221/222 involved in ovarian cancer SOCS3 ARF4 PTEN BMF STAT3 PMC4454164__F7 Proposed mechanism for RSV in the regulation of mtROS homeostasis through Sirt3 signaling pathway in HUVECs ROS1 SIRT3 PMC3405730__F2 IL-2 signals by activating three principal signaling pathways, the SHC/RAS/MAP kinase pathway, JAK1/JAK3/STAT5 pathway, and PI 3-K/AKT/p70 S6 kinase pathway GRB2 IL2RA JAK3 JAK1 TF IL2RB PMC4765995__F1 Polyp to colorectal cancer sequences OMP SMO PMC7427429__F3 Pathogen-derived molecules enabling VP22 to evade the DNA-sensing pathway in cells TBK1 CGAS IRF3 AIM2 IL1B PMC7663815__F11 Crosstalk between androgen and Notch signaling pathways in rodent Sertoli cells GC NOTCH1 HES1 PMC8303459__F1 MEK5/ERK5 Pathway in Health and Disease PAK1 KLF4 KLF2 PMC9256747__F2 Molecular mechanisms underlying suicidal NETosis and vital NETosis COX2 TLR4 MPO IL8RB PMC6520938__F1 Canonical Wnt signaling pathway APC CCND1 GPR49 PMC8116282__F3 Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry SDHC VHL IDH3B MDH2 HEL-S-26 SLC25A11 GOT2 FH EGLN2 SDHD SDHAF2 SDHA SDHB PMC6520938__F2 Canonical Notch signaling pathway CDKN1A CCND1 FURIN PMC12131388__F6 Drug-pathway-target-disease network of ATBC in ovarian damage (A) and infertility (B) IGF1R PTGS2 NFE2L2 MAPK14 BCL2L1 TNF HDAC1 STAT1 CASP3 TLR4 MMP2 ATM NFKB1 SRC IL2 BCL2 MCL1 PPARG PMC8265496__F4 Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs) PDC TLR7 TLR9 IRF7 IRAK1 TRAF6 IRAK4 MYD88 PMC7532258__F8 HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3B/Beta-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats GSK3B LRP6 PMC9216203__F1 Secreted proteins positively related to bone homeostasis and baseline Vo2max NOG SMOC1 COL9A1 COMP EPYC CRTAC1 PMC7067140__F1 DYSREGULATION OF METABOLIC ENZYMES IN TUMOR AND STROMAL CELLS: ROLE IN ONCOGENESIS AND THERAPEUTIC OPPORTUNITIES CS FH GDA MYC ACLY FASN HEL-S-162eP GLS PMC11682976__F1 Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy VEGFC EPO PDGFRA VHL PMC6169812__F1 New interactors of endothelial adherens junctions (AJs) RAB11A SRC RHO RASIP1 HEG1 TRIO PMC3938851__F1 Insulin/IGF-1 signaling and regulation TSC2 ULK1 TSC1 IGF1 GRB10 IRS1 RHEB PMC4426861__F1 Pathogenesis of Aortopathy in Marfan Syndrome and Related Diseases PLAT TGFBR1 TRAF6 TF PMC6338075__F5 Rhythms of life: circadian disruption and brain disorders across the lifespan TH CCK MAOA SIRT1 PMC4739352__F9 Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90 RIPK1 BAD IGF1 TRADD APAF1 MADD PMC2673547__F8 Oncogenic Function of ATDC in Pancreatic Cancer Through Wnt Pathway Activation and Beta-catenin Stabilization APC GSK3B PMC12155930__F6 Anti-Inflammatory Activity of Thymol and Thymol-Rich Essential Oils: Mechanisms, Applications, and Recent Findings ROCK2 FHOD1 ROCK1 ARHA PTEN TNF PMC4850137__F1 Reactions induced by IL-10 NFKBIA CHUK ACACA CD2 RELA MTOR MAFA PMC8303459__F3 MEK5/ERK5 Pathway in Health and Disease PAK1 MSC KLF4 KLF2 CDC42 PMC7816678__F3 Diversity in stimulus sensing, fuel sources, and thermogenic mechanisms of brown and beige adipocytes SLC7A5 SLC25A44 UCP1 TG CD36 PMC7432891__F1 Schema of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway and its regulators and effectors EBP FOS GRB2 APP BCL2 SP1 JUN PMC5743035__F8 Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters DHCR7 HEL-S-64p HMGCR PMC9510596__F1 Tryptophan metabolites in depression: Modulation by gut microbiota ASMT KYNU KMO AANAT PMC5468003__F5 Network analysis obtained from IPA of differentially regulated proteins (p ≤ 0.05) between recurrence (R) and recurrence-free (RF) patients STAT1 ADAR PML RAB1A USO1 DDX39B RNF213 MYO9B TAPBP PMC3845579__F1 Regulation of mammalian target of rapamycin (mTOR) by the LKB1/AMPK signaling pathway TSC2 TSC1 PTEN MTOR RHEB PMC7833367__F2 Biphasic role of wnt/Beta-catenin pathway in heart muscle development MESP1 DKK1 PMC4171766__F2 Top networks observed in Ingenuity Pathway Analysis (IPA) SRCAP CDA ERMAP NAB1 TSC22D3 CTCF SHE RPS11 HECTD1 ENDOD1 ASXL1 TACC1 ZNF331 PMC8478550__F3 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 SMAD2 SMAD4 NOX4 PMC8478550__F1 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 IL13RA1 SMAD2 ATF2 SMAD4 TYK2 JAK3 TNF PMC8182936__GA Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway NLRP3 IL1B PMC8478550__F2 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 SMAD2 SMAD4 PMC4159950__F2 MicroRNAs As Biomarkers For Clinical Features Of Lung Cancer MYC PTEN EZH2 PMC5833693__F6 Glucocorticoid-induced apoptotic signaling pathway BAD GC GRB2 BCL2 PMC5351412__F1 Differentiation potential of mesenchymal stem cells BMP2 MSC MTOR PMC11225869__F1 In alveolar general capillary endothelial (gCap) cells, IGFBP7 prevents FBXW2-dependent ubiquitination and degradation of NFKB1/2 NFKB1 IGFBP7 PMC8583721__F2 Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases SMAD2 SMAD4 PMC5702042__F8 Suggested model of activation of the NLRP3 inflammasome by Fonsecaea pedrosoi hyphae in macrophages NLRP3 IL18 SYK IL1B PMC3867791__F6 Regulated in DNA Damage and Development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1) TSC2 ULK1 TSC1 ATF4 EIF2A PMC3823475__F2 Membrane VEGF receptors expressed by astroglial tumour cells PIGF KDR GC PMC3828821__F1 How does the metabolism of tumour cells differ from that of normal cells TH CPT1A GLS2 CA9 CA12 HEL-S-133P HK2 FASN MAL PMC9367238__F2 Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer DKFZp781B1423 SMYD2 MDM2 MAPKAPK3 PTEN RB1 CCNE1 PMC4294653__F12 mTOR signaling pathway regulated by PLB in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis ULK1 RHO EIF4E HIF1A IRS1 INSR TSC2 RICTOR TSC1 PC ELF3 RPS6 RAN EIF4B PMC6289345__F5 The proposed metabolic pathway of cryptotanshinone in HLMs UGT1A9 CYP2C19 CYP3A4 CYP2A6 UGT2B7 UGT2B4 CYP1A2 PMC5058685__F7 Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway MMP2 HIC1 STAT3 PMC4294653__F13 mTOR signaling pathway regulated by PLB in DU145 cells.Notes: DU145 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis RICTOR ULK1 ELF3 EIF4E RPS6 HIF1A EIF4B IRS1 INSR PMC4036317__F11 How PLCG1 regulates USP1 phosphorylation to mediate 20E-induced gene expression for metamorphosis PLCG1 USP1 PMC9600272__F2 Emerging Role of ERBB2 in Targeted Therapy for Metastatic Colorectal Cancer: Signaling Pathways to Therapeutic Strategies TBK1 EGF SOS2 MYC GRB2 VEGFA MTOR TF PMC4294653__F11 PLB regulates apoptosis signaling pathway in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis BAD APAF1 BCL2 MCL1 CAD DIABLO HTRA2 BIRC6 CYCS BAX PMC3392173__F1 Wnt signaling pathways LEF1 APC SRC SOSTDC1 RHO DKK1 WIF1 PMC4337883__F2 Choline metabolism in malignant transformation CHPT1 SP1 PMC4394890__F2 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction ZBTB7A CTCF MYC SMAD4 PTEN ESRRA CEBPB TBP SP1 JUN NPPA EGR1 ZNF283 RFX5 FOS LIF VEGFA CEBPA RBX1 MAX RELA BCL2 YY1 TCF4 STAT3 PMC4394890__F5 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction EGR1 SMAD2 TGFBR1 VEGFA MYC SMAD4 PTEN COL1A1 GATA2 COL1A2 BCL2 YY1 RAF1 MCL1 SP1 JUN PMC11098157__F1 Metabolic pathway for S‐warfarin CYP2C9 CYP3A4 UGT1A1 PMC10568316__F2 Mφ-related inflammatory signaling pathways in NEC NLRP3 HMGB1 TLR4 IRAK1 TRAF6 IRAK4 MYD88 TNF GSDMD PMC8568295__F9 Hub gene multi-factor regulatory network ITGAM FPRL2 NR1i1 RUNX1 SP2 SPI1 KLF5 KLF4 SP1 WT1 C3AR1 SP3 PMC7242393__F10 Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics IRF3 PGAM5 MTOR PMC10568316__F1 Multifunctional role and mechanism of IMφs in NEC pathogenesis IGF1 BMP2 CXCL5 TNF ARG1 PMC3651771__F1 Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1RAvB3 integrin complex in tumorigenesis and angiogenesis IGF1R SDC1 IGF1 PMC4326712__F2 Simplified synopsis on the PI3K-AKT and RAS-MAPK signaling pathways and their interactions GAB2 GRB2 MTOR RHEB BAX PMC7010853__F8 Speculatively schematic diagram of this scientific hypothesis including the most significant SF (CLEF5), OS-SEs (GSG1L|35698|AP, GSG1L|35696|AP) and downstream pathway (Primary bile acid synthesis) CELF5 PMC8766727__F6 USP14: Structure, Function, and Target Inhibition USP14 NOTCH1 PMC7685564__F1 Cross-Kingdom Activation of Vibrio Toxins by ADP-Ribosylation Factor Family GTPases ARF6 ARF1 CFTR CPD PMC8185986__F2 F ig . 2.Mϕ regulation of PMN chemotaxis TLR4 IL8RB ADRBK1 PMC3904428__F1 Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target RALA RALBP1 PMC7967180__F1 The leukotriene signaling pathway GPR17 LTA LTB PMC8349014__F1 Flavonoids on diabetic nephropathy: advances and therapeutic opportunities MTOR RHEB BAX PMC10968226__F2 TRPV4 channels in osteoarthritis TRPV4 ACAN TNF SOX9 PMC7582185__F4 Transcription factor CREB1 exhibits an opposite regulation in the downstream genes between WT and VCP TG mice in response to 2W TAC GAD2 MYC HPGD PNMT ZFP3 FOS SSBP2 GAD1 CYR61 HLA-A LEP EGR2 KLF4 ARC CDH10 VCP COL24A1 CTNNA2 REN GEM HEL-S-14 FOXP3 CEBPD APOLD1 TACR3 GAL MKI67 IL1B SMS JUN MIDN NEXMIF ARFGEF3 IER2 SORCS3 KCTD4 CHRNA1 CALCB OTOF GRIK2 LYPD6 MUC2 TG PLCXD2 PRL NNAT SLC17A6 TAFA1 XKR4 INHA TIPARP PMC6529853__F5 Dysfunctional subpathway (path:04020_1) of calcium signaling pathway in CESC PTGFR EDNRA AVPR1A EDNRB GNA14 TACR2 PMC9368906__F4 LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis CD44 PMC7711540__F5 Validation and pathway analysis of elevated S100A8 protein in FSHD KRT16 FOS HEL-S-15 PROC HUWE1 SKA2 S100A9 PFN1 ATP11C HEL-S-108 TLR4 IGF1 TMEM245 TMSB4X TMSB10 S100A8 PANK3 JUN PMC7830067__F1 Metformin enhances CD8+/CD4+ ratio to favor an immunoreactive microenvironment TNF MTOR IFNG FOXP3 PMC11831438__F10 Scheme depicting the proposed mechanisms for the neuroprotective effects of Tat‐Nrf2 peptide treatment in ischemic stroke GCLC SENP6 PMC7416697__F7 ABCC4 function in SHH signaling SUFU PTCH1 GLI3 SHH SMO PMC3571350__F10 Schematic model of IFN-induced apoptosis in WISH cells STAT1 CASP3 STAT2 IRF9 TYK2 JAK1 CASP8 FADD PMC11014460__F1 Responses of HIFs to hypoxia or hyperoxia EPO VHL HEL-S-68p PMC5081117__F6 Targeted transcriptomic analysis DAO BCAT2 AADAT HEL-S-5 HAAO MTAP KYNU GOT2 LAP3 APIP HEL-S-8a CAD HEL-S-133P AGMAT HMGCL ALDH18A1 AMD1 DBT AANAT TDO2 HEL-S-61p IDO1 MTR ENOPH1 EHHADH ASL HEL-S-29 PMC9247101__F5 Targeting fibrosis: mechanisms and clinical trials EGF SMAD2 TGFBR1 TGFBR2 SMAD4 PMC7202451__F5 Gene expression in the actin cytoskeleton signaling pathway for the hepatic transcriptome of S FLNA APC GRB2 LBP SRC FGD1 CRK PXN GNG12 PMC4462367__F2 Schematic diagram of the signaling of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway involved in human cancers TSC2 RICTOR BAD TSC1 EGFR GSK3B MDM2 CCND1 PTEN EIF4E INPP4B PMC7202451__F6 Gene expression of the ILK Signaling pathway in the hepatic transcriptome of S NCK2 FOS BMP2 MMP9 MYC PTEN NACA RHO MTOR KRT18 RSU1 CASP3 COX2 RICTOR HEL113 PXN PMC10419859__F2 ATX/LPA signaling pathway in different inflammatory diseases LPL RHO LPA PMC7202451__F7 Gene expression of the signaling by rho family GTPases pathway in the hepatic transcriptome of S GFAP CRAT PARG CYFIP1 PKN1 PMC4462367__F1 Schematic diagram of estrogen receptor (ER) signaling PTEN SP1 MTOR PMC3097472__F1 Methionine, an essential amino acid required for protein synthesis, is the source of methyl groups for a number of methylation reactions such as methylation of nucleic acids, proteins, biogenic amines, phospholipids, and for creatine synthesis etc HEL-S-61p PMC7549162__F6 Comprehensive network construction of crucial signaling pathways and DEGs associated with HBV-ALF HLA-E HLA-DPA1 CTSS ICAM2 CD244 HLA-DRB1 HLA-B HLA-DOA HLA-DMA TYROBP HLA-A HCST HLA-DPB1 FCER1G HLA-DQA1 LCK SYK PRF1 SOS1 HLA-DMB PMC2882734__F6 Pathways of VLC-PUFA biosynthesis ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC9054177__F1 Molecular Basis of the Effect of Atorvastatin Pre-treatment on Stem Cell Therapy in Chronic Ischemic Diseases – Critical Limb Ischemia BAD IGF1 IGF2 VHL RHO HIF1A MTOR BAX PMC11969464__F2 Ingenuity pathway analysis of differentially enriched proteins BAD MARCKS BRAF HEL-S-15 MAPK14 TLN1 MTOR SYNGAP1 DLG4 AFDN APOE RAPGEF1 RELN PLG CDK5 SNAP25 CRK VAMP2 RASGRF1 ERC2 FARP1 CTNND1 RAF1 BDNF CLASP2 PMC10144233__F1 Heme b biosynthesis pathway UROD UROS HMBS CIT CP MAL PMC11969464__F3 Visualization analysis of pathways identified from normalized, significantly differentially-SUMO-enriched proteins EIF3A AGK RTN4 BSN SYNPO HOMER1 ACTN2 GSK3A RAC1 ARF1 RHEB EIF3K MAP4 ERC2 BRSK1 PTPN11 LETM1 DAP3 SYT7 AMPH RAB3C EPHA4 PMC4890990__F1 Molecular mechanisms of long noncoding RNAs on gastric cancer TINCR IGF2BP1 STAU1 RUNX1 BCL2 KLF2 SP1 MTOR E2F3 CDK6 PMC10144233__F2 Formation of uroporphyrinogen III (UPG III) and the branching of the heme b biosynthesis SHD UROD UROS HMBS CPD PMC11514755__F8 NF-kappaB signalling pathway CD14 IRAK1 TRAF6 IRAK4 IL6 MYD88 COX2 TLR4 VCAM1 TRAF1 LBP CD80 TRAF2 TIRAP PMC7016717__F3 Oncogenic activation of the STAT3 pathway in T-cell lymphoma JAK3 JAK1 STAT3 PMC7016717__F2 Janus kinase 1 (JAK1)/STAT3 signaling in DLBCL EGR1 SOCS3 MEF2B MYC NFKBIZ MYD88 BATF NFKBIA BCL2A1 NFKB2 BCL2 JAK1 MCL1 JUN IRF4 SGK1 STAT3 PMC9240244__F7 Working model of the protective effects of Rb1 against D-GalN/LPS induced ALI: Rb1 inhibition of the TLR4/MyD88/NFKB signaling pathway and NLRP3 inflammasome activation NLRP3 MYD88 RB1 PMC9570477__F7 An Integrative Transcriptional Network Revealed Spatial Molecular Interplay Underlying Alantolactone and Inulin Biosynthesis in Inula racemosa Hook f. SST STS PMC2908475__F2 The intracellular signaling network regulating T-cell trafficking and differentiation IL15 IL21R CCR7 IL2 PTEN IL-21 SELL BCL6 PMC6719725__F6 Assessment of network module identification across complex diseases SLA MPO RETNLB IL17F CTLA4 POR STAP2 HTRA2 RICTOR TFF2 RELA STAT4 GRAP2 HTRA4 TFF3 REL GRAP LAT PMC5824497__F2 NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning SIRT2 NAMPT NMNAT3 NRK SIRT3 NAPRT SIRT7 HEL-S-90n SIRT4 SIRT5 SIRT6 NMNAT2 SIRT1 PMC6003041__F3 Regulation of SREBP1 and lipid metabolism by oncogenic signaling in CSCs COX6A2 ACADS ACADVL ECHS1 PMC6003041__F4 Interaction between oncogenic signaling and lipid desaturation in CSCs EGF EGFR FGFR3 CDC2 ACLY FASN PMC6838739__F1 Signaling pathways in osteoclast (OC) differentiation, survival and death TRADD TRAF6 PTH MTOR JUN FADD PMC8151162__F4 Transcriptome Analysis of the Japanese Pine Sawyer Beetle, Monochamus alternatus, Infected with the Entomopathogenic Fungus Metarhizium anisopliae JEF-197 TBK1 MYD88 CASP8 NCR1 NCR2 PMC10933439__F1 Canonical Activin-, BMP-, and IFN-mediated signaling pathways STAT2 IRF9 SMAD2 SMAD4 SMURF1 SMAD9 USP18 STAT1 BMPR2 ACVR2B ACVR2A TYK2 JAK1 SMAD1 DKFZp781O1323 PMC5705900__F8 Possible mechanisms through which crocetin and AS101 reverse the early adaptive response of the ovary to CPM CPM SIRT3 PMC8674449__F2 Ecogenomics Reveals Microbial Metabolic Networks in a Psychrophilic Methanogenic Bioreactor Treating Soy Sauce Production Wastewater NHS FH TRO MAL PMC5455971__F2 Targeting iron metabolism in drug discovery and delivery ERFE BMP6 HAMP SMAD4 HFE IL6 SMAD1 DKFZp781O1323 TFR2 STAT3 PMC3706566__F6 Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization MFN1 MFN2 NRF1 SIRT1 FIS1 UCP3 UCP2 SIRT3 PMC2851161__F1 The Notch signaling pathway NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC7926651__F4 Main mechanisms of Kupffer cell activation during chronic ethanol exposure NLRP3 TLR4 IL1B PMC8593816__F5 Clinical Significance of Screening Differential Metabolites in Ovarian Cancer Tissue and Ascites by LC/MS DPYD DPYS CNDP1 CNDP2 CYP11A1 ALOX5 CYP7A1 FADS2 CYP2R1 ACSL1 ACADM CYP27B1 FASN PMC2492871__F4 Networks top-ranked by Ingenuity Pathway analysis after knockdown of TP53 (A) and LSR1+TP53 (B) RRM2B SPINK1 TNFAIP2 BNIP3 S100A4 PMC5833825__F6 Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence CXCR4 RPE IL1B PMC11931864__F6 Molecular mechanisms through which hUC-MSC-sec improves aged oocyte quality DAZL MSC BTG4 BDNF PMC7096478__F7 The possible mechanisms used by M APC NOTCH1 HES1 PMC5292006__F4 Ingenuity pathway analysis of uniquely hypomethylated promoters SOCS2 SOCS3 CTLA4 TNF FYN LCK GRB2 IL2 JAK3 CD80 JAK1 IL9R LAT PMC7096478__F8 The possible mechanisms used by M RUNX1 BEST2 PMC2586079__F1 COMPLEMENT ACTIVATION FRAGMENT Bb IN EARLY PREGNANCY AND SPONTANEOUS PRETERM BIRTH HEL-S-62p C1S PMC7096478__F9 The possible mechanisms used by M RUNX1 NOTCH1 PMC7214175__F7 Proposed model of metformin‐induced activation of the Hippo pathway in drug‐sensitive and drug‐resistant breast cancer cells NF2 SCRIB FRMD6 PMC7303083__F7 LPS-TLR4 MAPK pathway stimulated by 1% ECVE treatment of LPS-matured MoDCs HMGB1 IRAK1 IRAK2 TRAF6 HEL-S-44 IRAK4 MYD88 TAB3 PMC4836665__F3 Differences in Whole Blood Gene Expression Associated with Infection Time-Course and Extent of Fetal Mortality in a Reproductive Model of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection ITK CDC20 FYN CSK SMC3 APC GRB2 SHB SLK RAD21 FZR1 PMC4123209__F2 Tale of two cytokines: IL-17 and IL-22 in asthma and infection TRAF5 EBP TRAF6 TYK2 JAK1 TRAF2 IL17RC STAT3 PMC6720052__F7 Schematic of the signalling pathways involved in AVE 0991-attenuated pyroptosis and hepatocyte damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway NLRP3 IL16 NOX4 PMC8634426__F1 From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin ATM RAD50 ARHA NET1 H2AX MRE11A PMC11907527__F6 Subgroup-specific heterogeneity in common pathways NGF FACL4 IRAK1 RAB27A TRAF3 TRAF6 ALOX5 PLCG2 MYD88 UBE2V1 PRTN3 BCL10 HDAC2 SERPINA1 IFNGR1 CASP8 NT5E ICOS TNFSF8 MAP3K1 AREG FOS IL1RN MAP3K7 LCN2 TNF LTB4R TNFSF11 TRAF5 NFKB2 GH1 CARD10 TNFAIP3 TGFA TNFRSF17 TAB3 EGF CHUK BTRC HGF SGPP1 IL1R1 CR1 IL18 LDLR CD55 ELANE CD40LG BMP2 MMP9 PDK4 TNLG2B MAP3K7IP1 HDAC1 IKBKB CARD11 GHRL LTA TREM1 ERBB2 RELA ZAP70 CD40 ETV5 TRAF2 OSM LTBR TIRAP PMC8256170__F2 OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases APC CXCR5 TRAF2 PMC4266467__F1 iNOS: A Potential Therapeutic Target for Malignant Glioma EGF COX2 EGFR STAT3 PMC8637192__F6 Copper Tolerance Mechanism of the Novel Marine Multi-Stress Tolerant Yeast Meyerozyma guilliermondii GXDK6 as Revealed by Integrated Omics Analysis GCLC HEL-S-64p CIT PMC4532730__F1 Intercellular apoptosis-inducing ROS signaling LPO PMC11907527__F3 Additional analysis on Amini et al, J Neuroinflammation, 2023 (PMID: 36691064) PIK3R1 POLS NBEAL1 PPM1K TTC39C TMEM116 NUP205 PPP3CC PDP2 HIF1A MTMR4 CDK6 EPHX2 ILF3 PRKCQ EP400 CTLA4 PROCR GPR18 TRAF5 CLEC2D IL11RA P2RY10 PRKCH BEX2 GLS AKT3 HGF RPL22 PDE3A DPP4 CASK MTOR HOXC4 SYNE1 RNF144A PTPN11 LRCH1 CCL28 DDX5 NMT2 SLC39A14 GATA3 ZNF331 PFAS ADAM23 CD96 S1PR1 MTHFD1 IL23A PTPN4 WNT2B C1orf57 ZC3H8 RABL3 SWAP70 EXOC2 PMC8689983__F3 Reactome pathway knowledgebase 2022 ELAVL1 GABARAPL2 HIPK2 ZBTB9 HNRNPL GABARAP PMC2492871__F5 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR1 (A-B) ELF3 PLAUR MYOCD SERPINE2 PMC2492871__F6 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR2 (A-B) FLNA SPINK1 ADAM19 SERPINE2 PMC6545975__F1 Receptor signaling pathway and recruitment of IL-1RAcP IL36A IL36B MYD88 PMC8300159__F1 Crossroads between Zinc and Steroidal Implant-Induced Growth of Beef Cattle IGF1R IGF1 MMP2 MMP9 EGFR HBEGF GPER PMC6506518__F8 Proposed multi-target and multi-component action modes of hawk tea as a previously unrecognized cholesterol-lowering agent APOB LPL LDLR NPC1L1 PMC11929655__F3 Protein–Protein Interaction (PPI) Network and Enrichment Analysis TSC2 TSC1 SFN TP63 TXNIP HEL-S-93 YWHAG PMC4761371__F2 RhoGTPase switch at the cell–cell contact TIAM1 ARHA RAC1 CDH2 TRIO VAV2 PMC4532730__F8 High concentrations of photofrin-derived singlet oxygen triggers the generation of cell-derived singlet oxygen, catalase inactivation and intercellular ROS-dependent apoptosis signaling through the NO/peroxynitrite and HOCl signaling pathway LPO PMC4532730__F9 Catalase inactivation by low concentrations of photofrin-derived singlet oxygen requires an additional amplification step that is mediated by the FAS receptor and caspase-8A LPO PMC9008482__F2 mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate ELF2 ELF3 LARP1 EIF2A EIF4E MTOR PMC11929655__F1 MTOR signaling pathway TSC2 TSC1 MTOR DDIT4 RHEB PMC6895189__F4 Adaptive divergence of Notch signalling pathway in tiger CTBP2 NUMB MAML3 PSEN2 CTBP1 DTX2 JAG2 DTX4 LFNG MFNG DLL3 DVL3 ADAM17 HES1 CREBBP PSEN1 SNW1 DVL2 PSENEN NCOR2 PMC7102443__F8 Pleiotropic functions of Htt in the TLR-4 signal transduction system in BMMCs FYN TLR4 IRAK1 LYN TRAF6 SYK IRAK4 MYD88 SNAP23 PMC7048264__F7 HIF-2A regulation via DDX28 DDX28 RBM4 PMC11842281__F4 PI3K‐AKT signaling pathway by nSolver Software (PathView) MYB BAD PTEN RAC1 MTOR IRS1 RHEB TSC2 BCR MDM2 SYK EIF4B RBL2 CD19 PMC8722197__F6 Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis MYB ERF PMC5923370__F3 Summary of discussed cancer-relevant pathways that activate YAP and TAZ EGF EGFR SRC RHO ARHGAP29 AXL TGFA BMP4 PMC4926186__F2 Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses STAT1 ELF3 STAT2 EIF2A TYK2 JAK1 IFNAR1 PMC6860913__F3 TLR9 has been proposed to signal through two independent cascades, (A) the canonical inflammatory pathway and (B) the non-canonical stress tolerance pathway TLR9 IRF7 TRAF6 MYD88 PMC12170596__F3 Microbiota dysbiosis alters gastric epithelial cell signaling pathways CGAS ATG16L1 CDX2 RUVBL1 OLFM4 PTGER4 GPR49 SP1 PMC12170596__F4 Microbiota shapes the suppressive immune microenvironment NLRP3 TLR4 TLR9 GC IRF3 STAT3 PMC5147901__F3 Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection IL10 CSF1R MREG CX3CR1 HP CX3CL1 FBXO7 KLF4 TRAF2 NCOR2 IFNG PMC7586489__F1 Locations of DNA base lesions govern TNR instability through BER FEN1 OGG1 PMC7586489__F2 TNR expansions and deletions through BER FEN1 PCNA PMC12170596__F2 Microbiota increases host cell genomic damage and suppresses genome repair TLR4 MSH6 MSH3 MYD88 MSH2 PMC3552307__F1 Double-stranded and single-stranded RNA signaling pathway TLR7 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TRAF2 FADD TLR3 PMC3349304__F6 Identification of transcripts and proteins associated with hemocytes HEL-S-62p CD63 VTN TRAF6 MYD88 REL TRAF4 PMC6600448__F2 Molecular mechanisms of alcohol-induced apoptosis and autophagy in hepatocytes BTK GSK3B CCND1 CYP2E1 FADD STAT3 PMC11674514__F3 Various IL6 pathway inhibitions SOCS3 IL6 IL6R SOCS1 PMC8033034__F1 Unfolded protein response (UPR) signaling pathway ATF4 EIF2A XBP1 PMC8033034__F2 Relevant events involving IRE1A and PERK proteins at mitochondria–ER contacts (MERCs) MFN2 ATF4 MTOR PMC11839352__F4 枸杞多糖改善高原低氧环境雌性大鼠生殖损伤的机制研究 PIN1 TLR9 HDAC3 HTR1B BCL2L1 SLC22A6 ABCB11 DRD2 TRPV1 PRKCA KDR NR1i1 MMP2 HEL-S-11 DTYMK ECE1 ABCB1 HK2 CES1 HSD11B2 VEGFA AKR1B1 HMGCR DRD3 FDFT1 NR1C2 OPRK1 PRKCH IGF2R PRKCE FOLH1 SLC1A1 NR3A2 CHRNA7 ATP1A1 EGFR LGALS4 HEL-S-104 PTPRB TLR4 NEU3 SLC1A2 PTPN1 KDM5C IL2 CDC2 OPRM1 FBP1 FGF2 CA9 HPSE NR1C1 EGLN1 CASP3 ADRA2A CPT1A ADA ADRA1D STAT3 PMC5562963__F1 Early and lethal neurodegeneration with myasthenic and myopathic features DPAGT1 ALG13 ALG5 MPDU1 DOLK DPM2 DPM3 DOLPP1 RFT1 DPM1 ALG1 ALG6 ALG10 GMPPB PMC11674514__F1 IL6 classical and trans-signaling activation pathways ADAM10 IL6 ADAM17 PMC5779028__F8 Local TRPV4 channel‐dependent Ca2+signaling regulates endothelium‐dependent vasodilation in resistance‐sized PAs TRPV4 MALL GC CSA2 PMC8946148__F2 Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy TSC2 RICTOR TSC1 EGFR PTEN DEPTOR RHEB MLST8 PMC7794044__F4 Signalling pathways activated by peptidoglycan upon stimulation of NOD-like receptors NLRP3 ATG16L1 CARD9 IRF7 NLRP1 NLRP12 TRAF6 RIPK2 IL1B NOD2 PMC8206194__F2 Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints LRP5 LRP6 PMC5993794__F3 Ingenuity Pathway Analysis of SNX8, PCP2, KNG1, and RORA SNX9 RORA SNX33 SNX8 PMC4383744__F1 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape HEL-S-62p CD59 FH CD55 PMC4383744__F2 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape HEL-S-62p C9 CR2 C1S CR1 CP PMC8704836__F6 Lowering pO2 Interacts with Photoperiod to Alter Physiological Performance of the Coastal Diatom Thalassiosira pseudonana COX2 COX10 CYB SDHB PMC11667232__F6 Big data analytics for aortic aneurysm MMP12 COA1 TIMP3 SPN SKI POR MYLK PMC9348623__F6 Molecular Mechanisms of the Convergent Adaptation of Bathypelagic and Abyssopelagic Fishes GRK1 SRC RHO PMC8623813__F1 Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer FOS MYC JUN PMC7855863__F3 Key Metabolic Functions of Beta-Arrestins: Studies with Novel Mouse Models AgRP IRS1 RXRA PMC3782237__F4 Mammalian target of rapamycin pathway is deregulated by mutations in cancer TSC2 EGF TSC1 PTEN MTOR PMC3204462__F1 TRAIL signaling pathway and regulatory proteins BAD MOAP1 CASP9 DAP3 ARC MCL1 ARAP1 TRAF2 FADD BAX PMC7149927__F9 Schematic diagram showing the effect of MG-infection on chicken thymus tissues NLRP3 TRAF6 MYD88 MTOR IL1B PMC6736567__F1 Canonical Hh signaling PC SUFU SMO ADRBK1 ITCH CCND2 PMC12057268__F1 Interactions between chronic inflammatory pathways, MetS, and various skin diseases BTNL2 EGF TLR4 IGF1 BACH2 IL3 VCAM1 EGFR IL2RA IL4 SH2B3 PMC11624276__F8 Schematic diagram displaying the role and mechanism of GPR160 in bone cancer pain GPR160 SP1 MME PMC5141645__F1 Schematic diagram of HGF/c-MET signal transduction pathway HGF MTOR STAT3 PMC5125891__F3 Sphingolipids in Mitochondria TRADD TNF FADD BAX PMC7012211__F6 Schematic diagram displaying the impact of AREG on intrinsic apoptosis signaling BAD AREG EGFR BAX PMC5584463__F1 Mechanistic target of rapamycin (mTOR): A mediator of social development HP MTOR PMC7586489__F4 Crosstalk between BER and MMR promotes TNR expansions and suppresses TNR deletions FEN1 TNR OGG1 PMC2721971__F3 EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis† EGF EGFR GRB2 ARF6 CBL PMC8348732__F4 Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses SIRT2 HDAC3 MAX GSK3B MDM2 SIRT1 PMC9386470__F1 BTK, the new kid on the (oncology) block? BTK BCL10 BCR LYN MYC SYK MYD88 CD19 PMC9061815__F5 scATAC-seq analysis and heterogeneity of regulation between MGE and LGE NRF1 ASCL1 ID4 POU3F2 NR2F1 POU3F3 NRXN3 TSHZ2 TMEM123 OLIG2 ZNF704 SOX4 ZNF503 ZNF107 MAF RHBG HES5 NKX2-1 TMSB10 SOX11 ZFHX4 ZNF219 NR3B3 CREB5 DLX2 SST MAX MEF2C ACTG1 FOXM1 LHX6 LHX8 MEF2D NR2F2 IGF2BP3 ARX RHOB JUN ZIC4 SOX2 ST8SIA4 NFIB DLX5 PBX1 DLX1 ISL1 SMC3 JUND TCF4 PMC11939868__F2 Long non-coding RNAs (lncRNAs) regulate immune escape in the tumor immune microenvironment (TME) STAT3 PMC11939868__F3 LncRNA and Tils in TNBC MICB MYL2 MICA PMC7898723__F3 Whole‐exome sequencing of non‐BRCA1/BRCA2 mutation carrier cases at high‐risk for hereditary breast/ovarian cancer TDG UNG NEIL1 FEN1 RFC1 CHEK2 FAN1 ATM MSH6 RAD50 ESCO2 FANCA MSH2 MUTYH FANCE PMC2826517__F1 The current understanding of PELP1 signaling pathway EGF PELP1 EGFR SRC STAT3 PMC6387057__F1 Schematic depiction of the mTOR signaling network TFEB SKI CAD MTOR DEPTOR RHEB PMC5860940__F2 Simplified overview of the intracellular signaling mechanisms governing CCA cell motility and invasiveness SALL4 GSK3B BMI1 PTEN MTOR S100A4 FBXW7 SOX9 PMC8615881__F1 Matrix Metalloproteinases in Endometriosis: A Potential Target FGA MMP10 IL37 IL34 MMP9 EGFR MMP3 MMP7 COX2 HEL-S-94n MMP2 JAK3 STAT3 PMC8279385__F2 Specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development IL13 IL33 IL25 PMC7202522__F5 USP22-pivot gene-module-pathway network suggesting USP22 could affect multiple pathways by up-regulating UBC MYC RNASEL UBC UBE2J2 UBE2J1 AP4M1 AP1S1 UBE2W CDC2 SCARB2 MED1 USP22 SORT1 APC FBXO2 CDC25B UBE2A UBE2C CDC20 UBA2 CDC6 CDK2 CCNB2 CREM MCOLN1 UBE2L6 SOCS1 PMC6458165__F1 Networks related to immune modulation and inflammatory response NFKBID CD133 AMPD2 ADD2 PTPRE PTEN DUSP2 TNFRSF10B OSM ACR PMC6458165__F2 Ingenuity pathway analysis networks related to neurological disease are presented in this figure (A,B) AIP HEL110 POR ZNF331 PMC2587085__F1 Targeting EGFR and Src Pathways in Head and Neck Cancer ERBB4 ERBB2 ERBB3 EGFR SRC PMC5941822__F1 Insulin signaling pathway TSC2 TSC1 GSK3B MYC PTEN RHEB ASL PMC3152870__F4 Signalling pathway of type III interferons (IFNs) compared with type II and type I IFNs STAT1 IRF9 IFNGR2 IFNGR1 IFNG PMC5154826__F2 Hedgehog Signaling in the Stomach MSC SHH IL1B IFNG PMC2905627__F7 Schematic diagram demonstrates intracellular signaling events in the Ras/ERK1/2 pathway as well as the upstream and downstream cascades activated by GDNF in the C18-4 cells RET CDK2 GRB2 ATF1 GDNF PMC7341381__F1 Structure of the Slit/Robo protein ROBO3 ROBO1 ROBO2 PMC4475536__F3 Mechanism of action of paclitaxel BAD TLR4 MYD88 PMC3172101__F1 New additions to the Hippo pathway in flies (a) and man (b) AMOT CD44 WBP2 PMC5447946__F5 ENOs and 14-3-3 in neurodegeneration NLRP3 SNCA BAD LRRK2 PLG GSK3B PMC3845023__F1 Sulfate assimilation pathway PAPSS2 SLC35B2 SLC35B1 HEL20 PAPSS1 PMC6425613__F6 Functional enrichment and gene network analysis HEL-S-62p HLA-E SOCS2 IFITM3 FITM2 IL1R1 HLA-DQB1 CXCR6 CR1 IFITM1 PRTN3 C1QA CFD CFH FRS2 CCL13 FGF10 IL7R IFI30 CFP CCL19 PELI3 C1S TRIM68 ARAF IL13RA2 IRF8 TNFRSF11B HLA-DRB1 C3AR1 CNTF ADAR CD59 C1QB HLA-DQA1 TNFRSF1A IL33 IL2RA OSM IL18R1 PMC12179084__F2 Key signalling pathways implicated in macrocephalic ASD NF1 TSC2 TSC1 CHD8 PTEN MTOR RHEB PMC3497822__F7 The signaling pathway by which FSH promotes AKT activation in GCs GAB2 GC IRS1 PMC11662456__F1 Figure demonstrates PPARG and its relation to signaling pathways H1-1 H1-2 PMC5187887__F1 Schematic diagram representing chromosomal DNA and the major components of the DDR signaling pathway (top) ATM CDK2 BRCA2 BCL2 RAD52 ATR H2AX BRCA1 PMC5117143__F7 ATR is required to maintain G2/M checkpoint integrity and prevent apoptosis induced by proliferation-associated DNA damage HEL-S-62p ATM ATR BAX PMC7181472__F5 Kunxian capsule in treating RA TRAF6 RORA TNF MTOR STAT3 PMC7181472__F6 Mechanism of side effect caused by Tripterygium hypoglaucum hutch and the mechanism of alleviation compensated by the rest of herbs ASNS REST IMPDH2 NOS2 PMC10253306__F2 Interactions found in polyQ-containing ID hub proteins located in both cytoplasm and nucleus using protein interaction annotation of HPRD HDAC3 ATXN1 PMC10253306__F3 Splicing Modulators Are Involved in Human Polyglutamine Diversification via Protein Complexes Shuttling between Nucleus and Cytoplasm GRB2 RHO VCP CDC42 HAP1 PMC8316605__F1 Cryo-EM: A new dawn in thyroid biology TSHR TG PMC8316605__F2 Cryo-EM: A new dawn in thyroid biology TH HEL111 TSHR DIO1 TPO TG PMC8105667__F5 Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens – the extracellular matrix (ECM) receptor interaction signaling pathway CD47 CD44 VWF CHAD CD36 PMC8599584__F6 KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway EGF EGFR KIF15 CDC42 PMC9179967__F4 Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling PTCH1 GLI3 CCNB1 SHH SMO PMC8054134__F2 Sources of proline in RPE PYCR2 SLC6A20 PMC2891965__F8 Updates in the characterization of the COX-2 pathways in human neutrophils COX2 LTA PMC8054134__F4 Proline generates GSH and NADPH to counter oxidative stress ME1 HEL-S-26 PRODH ME3 PMC7113187__F8 Proposed mechanism of BMP6 signaling pathway regulated by PSMD14-ALK2 axis in colorectal cancers BMP6 SMAD4 SMURF1 SMAD1 DKFZp781O1323 PMC10861954__F4 Apoptosis and Inflammatory Signal Pathways Associated with Unremitted ER Stress and UPR ATF4 EIF2A TRAF2 PMC5072394__F1 Viral evasion of intracellular DNA and RNA sensing IRF7 IRF3 TRIM25 MAVS HEL-S-69p PMC3026989__F1 The innate immune induction pathway through RLR activation IRF7 IRF3 IFNB1 PMC8082775__F3 Nonsense-mediated RNA decay and its bipolar function in cancer SLC7A11 ATF4 EIF2A MAP3K14 UPF3A PMC3497822__F1 The signaling pathway by which FSH promotes AKT activation in GCs GAB2 GC IRS1 PMC4008642__F1 Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation EGF AIP BRAF EGFR PTEN MTOR PMC4021393__F2 Activation of the "Role of BRCA1 in DNA Damage Response’ pathways in NCR versus CR samples ATM ATRIP MDC1 BARD1 ATF1 MSH2 ATR MRE11A BACH1 IFNG PMC10861954__F3 Unfolded Protein Response ATF4 EIF2A PMC7944059__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating differentially expressed genes (DEGs), as identified by protein-protein interaction network analysis using STRING KIT GHR TRO TESC PMC3109408__F2 Simplified diagram of Kynurenine pathway: during neuroinflammation, 95% of the dietary tryptophan is metabolized along the KP within the brain HEL-S-90n KMO PMC12094478__F3 Mechanism of EVs in AKI CD5L KEAP1 SIRT3 PMC8358851__F1 Drivers of phenotypic variation in cartilage: Circadian clock genes DBP DAP NPAS2 PMC3411757__F1 Modular Nature of Dendritic Cell Responses to Commensal and Pathogenic Fungi MHC2TA RELB CD83 PLCG2 RHO TLR3 RNASEL STAT1 ISG15 RNASE1 OAS1 COX2 CARD9 IL16 BCL10 LYN CCL20 CCL17 SRC SYK CD80 RAF1 PMC6747549__F1 Schematic summary of the molecular pathways of F TIGIT MYD88 IL1B PMC9520027__F11 Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization KPG_010 RHO LPA NECTIN2 LPAR1 PMC6487480__F1 Polyamine metabolism and cancer: treatments, challenges and opportunities MTAP SMOX PAOX APRT ARG1 PMC4326377__F10 Activation of BV2 microglia could trigger a strong inflammatory reaction in PC12 cell apoptosis by toll-like receptor signaling pathway TLR4 MYD88 BAX PMC395917__F5 BMP4 and LIF signaling in pluripotency LIF SMAD4 MAP3K7IP1 SMAD1 BMP4 STAT3 PMC9549772__F2 Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment NOTCH2 PMC7348083__F2 Heat shock protein 90 inhibition and multi‐target approach to maximize cardioprotection in ischaemic injury KEAP1 CDC37 HSF1 PMC11884866__F10 Diagram illustrates the role of PCBP2 in immune evasion in prostate cancer TBK1 IRF3 PMC3770300__F1 Computational framework of 3D vascularized bone regeneration within a porous biodegradable CaP scaffold RUNX2 BMP2 MSC PMC1895551__F1 Prosurvival signaling pathways and their downstream targets CASP3 BAD GRB2 PMC8674840__F5 ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses STAT1 STAT2 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC5607427__F6 Model of Syk and SFK signaling in B MARCO SYK RAC1 CDC42 PMC3338536__F4 TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators POLD2 HEL70 HEL-S-92n SGTA PRIM1 UBC HMGN1 KLRG1 SF3B2 KEL CRYBA4 TARDBP PSMD11 PMC3291304__F1 Protein quality control systems are potential targets for mechanism-based treatments of demyelinating Charcot-Marie-Tooth disease (CMT) MPZ USP14 PMP22 PMC4714209__F1 Biosynthesis of Sec on its tRNA SEPSECS PSTK PMC8822596__F2 Ferroptosis in cancer and cancer immunotherapy GPX4 STEAP3 GCLC HEL-S-64p TPD52 RAB7A DHODH DKFZp686F0183 TF PMC8822596__F3 Ferroptosis in cancer and cancer immunotherapy GPX4 LPCAT3 FACL4 KEAP1 SLC7A11 NF2 HEL-S-64p NOX4 HEL-S-44 TFRC PTEN HCAR1 PMC8803838__F2 Neutrophils in chronic inflammatory diseases NLRP3 CTSG CXCL1 IL18 MPO ICAM2 CD177 IL22 CXCL2 IL1B PMC8113860__F3 Crosstalk and regulation of innate immune cells in the esophageal cancer tumor microenvironment HMGB1 SIRPA CD47 CXCL16 CXCL10 CCL20 CXCL9 CXCL3 CXCL2 CCL2 STAT3 PMC5385394__F1 Major pathways associated with pancreatic ductal adenocarcinoma and site of action of current treatments EGFR SMAD4 MTOR PMC4123742__F3 Current model for replication-independent ICL repair REV1 POLK XPC ERCC1 XPA POLN PMC6749452__F8 The metabolic pathway networks of particularly significant potential biomarkers for the therapeutic effect of p-b4 on MSU crystal-induced GA rats ALOX5 LTC4S KDSR PMC8333862__F1 NAD+ Homeostasis in Diabetic Kidney Disease NAPRT NAMPT HEL-S-90n PMC8500707__F1 Genomic Landscape of HIV-Associated Plasmablastic Lymphoma MYC CD44 NOTCH1 PMC9697247__F1 Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases TSPAN12 RECK APC GSK3B LRP5 PMC2720065__F8 Proposed signaling pathway of mmLDL-induced, TLR4/Syk-dependent ROS generation and proinflammatory cytokine expression CD14 TLR4 SYK MYD88 PMC7974260__F2 Representative diagram of circRNAs that interact with the circRNA-miRNA-mRNA regulatory network/RBPs and regulate oncogene or tumor suppressor signaling pathways VEGFC SLC8A1 VEGFA SMAD4 PTEN FNTA HEL-S-133P ZNF609 MYLK PRRC2A PMC3161675__F3 Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer TBX2 TBX3 MYC MDM2 CCND1 CDK4 BMI1 JUNB DMP1 PMC10511911__F5 Regulation of insecticide resistance mechanisms involves epi-transcriptome signals, detoxification signaling pathways, and long non-coding RNAs (lncRNAs) AHR KEAP1 TF PMC8295591__F2 HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking RANBP1 RAB11A RAB27A RAB7A ABCE1 PMC6976902__F1 miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo SMO PMC5274667__F6 Cross talk between lipid/glucidic metabolism and cancer ANGPTL3 ANGPTL4 IGF1 LPL PMC5274667__F3 Molecular mechanism governing ANGPTL4-mediated TG hydrolysis ANGPTL4 GPIHBP1 TG PMC8850798__F8 Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway DLL4 HEL-S-134P NOTCH1 HES1 PMC2959101__F4 Schematic diagram of NELL-1 signaling pathways in osteoblast cells NELL1 RUNX2 BMP2 SMAD6 SMAD4 SMAD1 PMC4123742__F7 Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair IL1A FANCD2 BLM SLX4 EME1 MRE11A BRCA1 FAN1 RNF8 FAAP24 RAD50 FANCM RAD51 ERCC1 FANCL ATR FANCB PMC6555892__F1 MINA Workflow ATG12 EGFR IL12A PTPN22 DGKA STAT4 GRB2 CXCL9 IL2 IL2RA IL-21 IL10RA IFIH1 IL18R1 SH2B3 PMC6200076__F1 Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma BRAF MTOR SGK1 PMC8263687__F8 Novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Krüppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway MFAP5 KLF16 CDK2 CDH2 PMC5795269__F1 Nicotinamide adenine dinucleotide biosynthetic pathway NAMPT SARM1 HEL-S-5 PMC6896717__F8 The schematic model of the process of regulating Akt/mTOR signaling by NL3 TSC2 TSC1 PTEN RHEB PMC7555474__F5 Rap1 promotes tumor progression via disruption of E-cadherin-mediated cell adhesion RAP1GAP CDH2 PMC9687982__F1 Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury NLRC4 NLRP1 AIM2 PMC8514845__F2 Scaling the tips of the ALPS SOCS3 STAT3 PMC10525645__F1 Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development SLC25A3 ATP7B COX17 ATP7A ATOX1 HEL-S-44 COMMD1 CP CCS PMC5747363__F2 Molecular targets of and mechanisms of resistance to major antimalarial drugs DHFR CYB DHODH DHPS PMC4506514__F1 Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma NF1 ATM FRS2 MDM2 GRB2 PIK3CA CDK4 FGFR4 PTEN RB1 SOS1 CDKN2A PMC7339444__F8 Pcdh8 in Wnt/PCP signaling in Xenopus DAAM1 PCDH8 ARHA RAC1 PMC10525645__F2 Simplified scheme for the conversion of food-derived copper into biovaluable copper ATP7B COX17 ATP7A ALB ATOX1 HEL-S-44 CP PMC6539971__F1 Microtubule-associated protein 1 light chain 3 (LC3)-P62 autophagy signaling pathway ATG12 ATG3 DKFZp686F0183 PMC11395544__F9 Oral Administration of Probiotic Bifidobacterium breve Ameliorates Tonic–Clonic Seizure in a Pentylenetetrazole-Induced Kindling Mouse Model via Integrin-Linked Kinase Signaling CASP3 HEL-S-28 PMC12146023__F2 Casein kinase 1 epsilon (CK1E) as a potential therapeutic target in chronic liver disease TBK1 APC EGFR GLI3 GSK3B TRAF3 LRP5 LRP6 FASN PMC8443620__F2 Metabolic capabilities in three new actinobacterial classes TH MAL PMC3721281__F2 Asparagine-linked glycosylation pathway RFT1 DPM1 ALG1 ALG3 ALG13 ALG6 ALG10 ALG5 PMC3219404__F1 Putative involvement of the receptor for advanced glycation endproducts (RAGE) during infection HMGB1 VCAM1 S100A12 PMC4087161__F2 Phosphorylation of Foxo1 at S253 by Akt promotes Foxo1 cytoplasmic retention and ubiquitination, which serves as a central mechanism controlling Foxo1 stability and activity () SIRT2 PRMT1 DYRK1A PMC12057185__F2 Processes of the three major classes for protein lipidation ICMT RCE1 NRAS RHO HRAS PMC9503909__F8 Fractionated Proton Irradiation Does Not Impair Hippocampal-Dependent Short-Term or Spatial Memory in Female Mice MYADM MTX2 ATP6V0C H3F3B ATP6V0D1 COX6B1 H2AJ H2AX PMC9629566__F3 Niloticin binds to MD-2 to promote anti-inflammatory pathway activation in macrophage cells TLR4 MYD88 PMC12057185__F7 Cohesive model of lipidation in the TME TLR4 HGF BCR MICB LYN MICA IRF3 RAC1 TNF HEL-S-133P PMC12057185__F5 S-palmitoylation within the TME ZDHHC19 ZDHHC18 ZDHHC9 ZDHHC5 ZDHHC13 MTOR ZDHHC3 HEL-S-133P GSDMD ZDHHC7 PMC12057185__F6 S-prenylation within the TME AMOT ROCK1 EGFR GRB2 CRACR2A ARHA SYK RHO RAC1 DEPTOR RHEB CLEC9A PMC12057185__F3 Comprehensive kinetic model illustrates dual lipidation interplay within the TME signaling pathways FYN APC LCK LAT MAVS PMC12057185__F4 N-myristoylation in the TME BTK CGAS BAD BCR LAMTOR1 FGF10 SRC ACSL1 IRF3 MTOR ARF1 STAT3 PMC6429383__F7 Compound-target network of 3DC2ME F10 CTSS PLK1 METAP2 ALB MAPK14 POR PTGS1 DRD4 FGFR2 CACNA1A TRPV1 PRKCA POMC KDR ACACB SRC SMO GABRA2 NR3B3 NOS2 SLC12A1 ABCB1 RPL3 ITGB3 CTSK CES1 LYZ MAPK10 TUBB1 VEGFA CACNA2D3 ADRB2 FABP6 CACNB3 CACNG1 GABRP CHRNA2 ADGRD1 RXRA EDNRB PDE4B PRKCB CYP2C9 NFKB2 DHFR NR1C2 BCL2 PTGDR2 RORA CACNB1 TH EGF REN NR3A2 CACNB4 RARA RARB HRH1 HBA2 CACNA1S FECH SHBG NR1B3 APP TACR3 GNRHR KIT PRSS1 PTGS2 NR1C1 CFTR CHRM4 NFKBIA CACNA1G LCK GNAS FLT3 PPARG MME CYCS PMC4672393__F1 Complement System and Antibody Mediated Transplant Rejection C4B_2 FH C4A CR1 PMC4109688__F2 Toward T Cell Protein–Protein Interaction Activity Relevant to Alopecia Areata LCK ZAP70 LAT PMC8113373__F4 CircRNAs: role in human diseases and potential use as biomarkers LATS1 LATS2 MKI67 AURKA PMC5496785__F1 Restore the brake on tumor progression PTCH1 GLI3 SHH SMO PMC4985808__F7 Transcriptomic analysis of heteromorphic stamens in Cassia biscapsularis L TH CBL PMC7546716__F1 T-cell polarisation in COVID-19IL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs RORC TH CCL8 CCR2 CXCL10 CCL2 MYD88 FOXP3 IFNG CXCR3 NLRP3 IL16 IL33 CXCL9 IL2 GATA3 STAT3 PMC8113373__F2 CircRNAs: role in human diseases and potential use as biomarkers APC GSK3B MYC CCND1 DVL2 ITCH PMC9709075__F6 Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus OAS2 OAS3 CAST IFITM2 IFNA2 IFNB1 IFITM1 PNPT1 PMC7893118__F1 TGFB signaling SMAD2 GRB2 SMAD6 SMAD4 PMC7602704__F1 Involvement of TPMT on the thiopurine metabolic pathway AOX1 IMPDH1 XDH TPMT PMC6170637__F4 Animal and plant cells NLRP3 NOD1 NLRC4 RPS2 NOD2 PMC8640216__F1 Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin ATF4 EIF2A PMC6170637__F3 Animal and plant cells TH TLR4 RAN MAL PMC9343597__F1 Present and Future: Crosstalks Between Polycystic Ovary Syndrome and Gut Metabolites Relating to Gut Microbiota SHBG PYY PMC7002574__F4A Pathway and network analysis of more than 2500 whole cancer genomes PIK3R1 MIB1 PBRM1 KEAP1 ALB MYC NRAS SMAD4 RB1 MYH10 CDKN2A ARHGAP35 FBXW7 DTL SOX9 SOX4 HEL-S-66p NF1 NOTCH1 HEL-S-44 B2M CASP8 NTRK2 RELN CNOT2 APC HNF1A CALM1 HLA-A VEGFC VAMP2 CDKN1A SUFU PTCH1 STK11 SPOP TERT EIF4A2 PLCG1 RPL22 COL3A1 PTPRK TGFBR2 CDK12 FOXA1 MEN1 KDM5C HNRNPR CBX3 VHL DDX3X ARHA RAC1 PS1TP5BP1 PTPRC CREBBP GIG8 CNBP EPHA2 BCL9 PYGL NFE2 PRKAR1A ARID2 NR2F1 CBFB SMARCA4 ACVR2A TLE4 NCKAP1 BTG2 NOTCH2 BHLHB2 PLAUR BRD7 HRAS SRSF9 STAG2 HOXB5 KMT2C ZFP36L2 PCF11 HNRPA3 PCDH9 BRCA2 KLF4 MLL2 TBL1XR1 BRAF EGFR PTEN CITED2 FST ATM SRSF4 HOXA10 GATA3 BAX SOX2 RNF43 NFE2L2 AJUBA TNFRSF11B RRAS2 GAP43 RBMX RPL5 PMC8996410__F3 Proteolysis-targeting chimeras (PROTACs) in cancer therapy WEE1 BRD3 CDK2 EGFR CDK4 BRD7 BRD2 CDK6 BRD4 PMC12146603__F3 Neurotransmitter pathway affected by genetic 5‐HTT inactivation at PND8 GAD2 GRIA4 GLS PMC6606846__F2 Regulation of (p)ppGpp metabolism in Gamma-proteobacteria RELA HPR PMC11313179__F7 Illustration of the most significant regulated target genes related to PPAR signaling pathway PLIN5 LPL NR1C1 PMC9168430__F3 Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence IDO1 TPH1 AHR PMC4568143__F1 From bench to bedside: what do we know about Hormone Receptor-positive and Human Epidermal Growth Factor Receptor 2-positive breast cancer? HRG EGFR TGFA PMC4150834__F2 MC1R, the cAMP pathway and the response to solar UV: Extending the horizon beyond pigmentation DKFZp686L0365 NRAS MC1R ADRBK1 PMC5809511__F4 Non-canonical Wnt signaling at the primary cilium INVS FZD3 ARHA MKS1 PMC8238251__F1 Endogenous AGE formation and pathobiological actions of RAGE receptor ligands HMGB1 PC JAK1 PMC8111493__F1 Regulatory T cells in ischemic stroke CCR5 CCR6 AREG MMP9 EGFR CCL20 CCL5 CCR8 CCL1 STAT3 PMC6398892__F2 Regulation mechanism of ECM/integrin/EphA1‐mediated cell adhesion HEL-S-28 EPHA1 ARHA PMC5714692__F2 Nutrient regulation of pancreatic Beta-cell proliferation TG CD36 PMC5845716__F1 TANK-binding kinase 1 (TBK1) in humoral responses TBK1 CGAS TLR4 GC IRF3 OPTN TLR3 MAVS ICOS PMC11809008__F9 HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway NLRP3 GSDMD PMC6064949__F10 A model depicting the mode that hypoxia exacerbats acute lung injury (ALI) via the toll-like receptor 4 (TLR4) signaling pathway and the protective effect of hypoxia-inducible factor 1 alpha (HIF-1A) CD14 IL18 TLR4 LBP IL6 IL1B PMC1216340__F10 Schematic model depicting potential mechanism that might contribute to epithelial-specific regulation of the CFTR gene EBP YY1 CFTR PMC5435082__F1 Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes FADS2 FADS1 GLA PMC64811__F2 Failure of endogenous regulation of wound-healing in idiopathic pulmonary fibrosis (IPF) COX2 PMC5903677__F3 Therapeutic targets for brain injury for nanoparticle mediated drug delivery EPO NPS BDNF PMC3267701__F1 Amyloid precursor protein (APP) processing pathway HEL111 EGFR PMC8802892__F5 Transcriptomic and Metabolomic Analyses Reveal Inhibition of Hepatic Adipogenesis and Fat Catabolism in Yak for Adaptation to Forage Shortage During Cold Season IGF1 SCD LPL LDLR TG HEL-S-104 PMC12090542__F1 Five signalling pathways in regulating the immune microenvironment of DW LEF1 SMAD2 APC LRP5 SMAD4 SRC LRP6 MTOR TF PMC2963177__F2 Integration of non-SMAD and SMAD signaling in TGFB1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells SMAD2 EGFR SMAD4 ARHA PMC8949198__F1 Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives MAF KEAP1 FN3K PMC7021762__F7 Components of GFI on KEGG gene networks PIK3R1 BRAF EFNA1 EGFR NRAS PTEN MTOR GADD45B EP300 NFKB2 PIK3CA TNFRSF10C FGF7 PMC5122403__F8 Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation TLR4 IRAK4 MYD88 MTOR PMC9166893__F8 Essential role of CK2A for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint MCM3 MCM5 CLSPN MCM6 MCM2 CDK2 ATRIP MCM7 ATR H2AX CDC45 PMC5777733__F12 Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer PIAS2 PIAS1 SAE1 TF PMC9445673__F8 Gene network downstream plant stress response modulated by peroxisomal H2O2 HSF4 HSPBP1 IRAK3 CALML3 CRYAA PMC5204325__F1 Cross talk between the transforming growth factor B (TGFB) family and Wnt signaling at multiple points APC SMURF2 SMAD4 SMURF1 PMC8108031__F1 Repurposing metformin for the treatment of gastrointestinal cancer IGF1R IGF1 MTOR PMC6430635__F4 Different subcellular sources of MHC-I molecules for cross-presentation RAB11A SCAMP3 CD74 PMC6430635__F5 Convergence of three vesicular pathways of endocytic traffic on the cross-presentation compartment in dendritic cells RAB11A RAB27A SEC22B RAC1 MYD88 SNAP23 PMC3757665__F2 Nrf2-Keap1 signaling pathway HMOX1 PMC5509726__F3 Protein-protein interaction networks of metabolism related pathway enriched genes PIG59 ACSS2 B3GNT3 ST3GAL6 SIAT4C PERP B3GNT7 B4GALT2 PKLR B4GALT4 PCK2 HK2 HEL-S-281 FABP2 FBP2 HEL-S-30 PGM2 HEL-S-28 FBP1 APC CA9 HEL-S-87p FUT5 DBI FUT8 FADS2 CPT1A ETHE1 B3GALT2 ST3GAL1 PPARG B3GALT5 PMC6910162__F1 Overview of metabolic pathways in atherosclerosis and trained immunity ABCG1 HK2 CD36 PMC8830041__F7 Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells ISG15 SOCS3 ISG20 IL17RA TRAF6 TYK2 IFNAR2 IL17RC SOCS1 USP18 PMC5509726__F6 Protein-protein interaction networks of lipid metabolism related pathway enriched genes ALOX15 PLD3 MTTP GPAM DGKA DGKE PLA2G2D PLA2G4F ABCA1 PLA2G12B GPD1L PLA2G2A PLA2G10 CD36 PMC2801624__F1 A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches MYF5 PAX7 NOTCH3 PMC8790554__F2 Celiac disease: From genetics to epigenetics TUG1 UNG TF PMC9113239__F6 Fabrication and evaluation of a BMP-2/dexamethasone co-loaded gelatin sponge scaffold for rapid bone regeneration RUNX2 BMP2 ID1 SMAD1 DKFZp781O1323 PMC8117216__F1 Repositioning of Antiparasitic Drugs for Tumor Treatment PAK1 SOX2 CD44 MTOR MAST1 BAX CD24 PMC8113030__F3 Redox regulation of the insulin signalling pathway PTEN PMC3646677__F1 B-Raf protein and signaling pathways MAP2 BRAF MAP4 EGFR GRB2 CR2 FLT3 MTOR CR1 PMC8113030__F4 Redox regulation of the insulin signalling pathway GSK3B PMC5958133__F6 Gene transcription in key nutrient metabolic pathways involved in lipid synthesis between L SCD DLAT HEL-S-162eP PMC8113030__F5 Redox regulation of the insulin signalling pathway IGF1R IGF2 INS PTEN IGFBP5 IRS1 IGF1 IGFBP1 IGFBP4 IGFBP2 IGFBP6 SGK1 AKT3 PMC9389448__F2 Modes of action and diagnostic value of miRNAs in sepsis AGO2 DGCR8 DROSHA RAN PMC9167543__F2 MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer APC WNT1 GSK3B JUN PMC9389448__F3 Modes of action and diagnostic value of miRNAs in sepsis CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TNF MAP3K7IP1 TIRAP TAB3 PMC3852967__F3 Interaction network of genes differentially expressed in response to glatiramer acetate (GA) DEFA4 ICAM2 PPBP IL18 POMC XCL1 CYP2C19 AgRP TNFSF14 SLC5A5 NOTCH4 CD34 CXCL10 AIF1 GHRH PTPRC HCST VCAM1 IL27 IL2RG IGFBP1 CXCL9 ADCY6 OXT IL-21 ITGAV TRAF2 PTPRCAP PMC6886858__F6 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus DHRS9 STAT1 RBM43 STAT2 IRF7 PDIA4 IRF-1 SLFN12 FAM72C PMC6441925__F1 DNA repair pathways with mutated genes highlighted RFC1 RARA PALB2 ATM BRCA2 BRIP1 MSH6 MSH2 MRE11A BRCA1 PCNA PMS1 PMC7418032__F6 Autophagic Clearance of Active and Damaged Mitochondria in HSCs PINK1 ATAD3A FLCN ATG16L1 TSC1 TFEB ATG12 BNIP3 ATG10 MTOR DKFZp686F0183 PMC8203498__F1 Representation of the signaling pathways involved in B-cell clonogenicity induced by clonogenic vp17s CDK2 EGFR RAF1 JAK1 MSH2 PMC7921306__F1 Genomic and non-genomic mechanisms of glucocorticoids IL10 IL6 TNF PMC3475172__F1 Model of canonical eukaryotic translation initiation pathway ELF2 EIF2A PMC6886858__F4 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus STAT1 PML PLK1 IRF7 CXCL10 TNFSF10 CCL2 IFIH1 IRF-1 PMC3243350__F1 Biosynthetic pathway of oxylipins in Arabidopsis ECD COCH PMC6942823__F6 Inhibitory effect of Tt-ME in RAW264.7 macrophages TLR4 IRAK1 SRC SYK MYD88 STAT3 PMC3929501__F1 a) Digrammatic representation of follicle growth from the non-proliferating pool of primordial follicles TSC2 TSC1 PTEN RPS6 PMC2712786__F1 Pathways of extrinsic and intrinsic apoptosis, highlighting roles of Bcl-2 family members BAD BIK BMF HRK PMC10138595__F3 PGE2 Promotes Immunoregulation through Cross-Regulation between Beta-catenin and NFKB by Activating the Wnt-Beta-catenin Signaling Pathways APC GSK3B PMC3064126__F6 PHEX, DMP1, matrix extracellular phosphoglycoprotein (MEPE), and ASARM peptides are proposed to dynamically regulate FGF23 expression in bone VIT FGF23 DMP1 PMC10138595__F1 Cytokine Storm and ALI/ARDS Induced by Influenza Virus Infection HMGB1 TLR7 IRF7 IRF3 MYD88 PMC12016489__F8 Two major complexes of the mTOR signaling pathway and their pathways TSC2 TSC1 DEPTOR RHEB MLST8 PMC6030168__F7 Hypothetical model showing that imbalanced LIMK1 and LIMK2 expression activates the WNT/Beta-catenin pathway and leads to CRC progression and EMT-induced metastasis LIMK2 LIMK1 PMC1964754__F6 Furin in development, homeostasis and disease EDAR MMP2 FURIN PMC4440819__F7 DA-Raf-Mediated Suppression of the Ras—ERK Pathway Is Essential for TGFB1-Induced Epithelial—Mesenchymal Transition in Alveolar Epithelial Type 2 Cells ACTA2 SMAD2 FGF2 PMC7072529__F1 Hypothesised regulation of extracellular matrix composition by the cilium and ciliary proteins HEL-S-11 PTCH1 TIMP3 ARF4 SMO INTU ACAN IFT20 PMC5346543__F9 Diagrammatic presentation of the mechanism of EMAP-II in combination with TMZ suppressed malignant biological behaviors of GSCs via miR-590-3p/MACC1 inhibiting PI3K/AKT/mTOR signaling pathway MACC1 IGF1 MTOR PMC7696686__F6 The current working hypothesis PINK1 MMP2 RHO RAC1 OPA1 PMC6333051__F2 IL-6 signaling in the tumor cell of the bone marrow niche GRB2 MTOR STAT3 PMC5553399__F8 Proposed mechanism for G2 phase-specific nuclear export of CENP-F CENPF NUP133 CDC2 PMC3851442__F2 Transposable elements and their potential role in complex lung disorder TH APC PMC9420447__F7 Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages TBK1 CD14 TLR4 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 PMC8801426__F2 G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases STAT1 AVP IFNAR2 ADRBK1 IRF-1 PMC10031257__F3 Focal adhesion proteins in skeleton and diseases MMP10 ADAMTS5 RUNX2 VTN SRC SOX9 STAT3 PMC7760926__F1 Role of oxidative stress in muscle wasting during cancer cachexia IGF1 ATF4 JUNB MTOR PMC6492276__F2 Biosynthesis of O-GlcNAc and UDP-GlcNAc OGA OGT GNPNAT1 GFPT1 PMC9408832__F3 Targeting the Sphingolipid Rheostat in Gliomas SGPP1 SMPD2 GBA2 ASAH2 SMPD4 SGMS1 UGCG ACER1 CERS3 SGPL1 ACER3 LASS1 SMPD1 CERS5 DEGS1 CERK SGMS2 DEGS2 KDSR CERS2 CERS6 SGPP2 PMC11896785__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation ST3GAL3 MAGT1 VMA12 ATP6V0A2 TRAPPC11 SLC39A8 COG8 FCSK COG7 SSR4 SSR3 PRKCSH COG1 VMA22 OSTC DPM2 VMA21 RFT1 SLC35A1 ALG3 SLC35A3 TMEM165 ALG6 ALG10 COG6 GMPPB COG5 COG3 B4GALT1 TUSC3 MAN1B1 GANAB ALG13 NUS1 SLC35C1 COG2 ALG5 ATP6AP2 DOLK DPM3 DHDDS DPM1 FUT8 STT3A STT3B ALG14 MGAT2 DDOST PMC3060320__F2 Schematic illustration of signalling within the type I interferon (IFN) system IFNA21 TLR9 SOCS3 TRAF3 TNFSF13 MYD88 PIAS2 IFNA2 IRF-1 IRF2 IFNW1 IRF7 STAT2 IRF8 IRF9 MAP3K7 IRF3 IFNAR2 PDC AZI2 TNFSF11 IFNK CXCR4 TNFAIP3 IFIH1 TNFRSF17 TBKBP1 IFNA17 IKBKE TANK IFNA4 TRADD RIPK2 TNFRSF13C ZBP1 IFNA5 IFNA7 TLR8 IFNA6 IFNA8 TLR7 TLR4 IFNA13 IFNA14 IFNA16 opn IFNA10 IRF4 TNLG2B TLR3 IKBKB CXCR3 NRP1 PIAS1 TYK2 FADD TIRAP SOCS1 STAT3 PMC9399520__F7 Celastrol ameliorates osteoarthritis via regulating TLR2/NFKB signaling pathway COX2 MYD88 TIRAP PMC8721241__F3 Updated role of ABA in seed maturation, dormancy, and germination SNRK ABI3 MAPK11 PMC5157899__F4 PEP-mediated metabolism in thermogenic cells of S PPIH MAL PMC2731675__F3 FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION IL1A PC BCR GC CD40 PMC4705593__F1 Cholesterol biosynthesis pathway FDPS FDFT1 LDLR ABCA1 HMGCR PMC7333652__F8 Microenvironment-related gene TNFSF13B predicts poor prognosis in kidney renal clear cell carcinoma HEL-S-61p HEL-S-182mP EPN1 UCK2 LSM6 SRC APRT TNLG7A PMC8580647__F4 Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling RUNX2 SMAD2 SMAD4 TGFA SMAD1 PMC7226777__F1 Principal functions of the 18-kDa translocator protein (TSPO): initiation of programmed cell death, including apoptosis, as well as regulation of the cell’s nuclear gene expression CLK1 FOS MYC ID3 PBR BAX PMC2812698__F1 Signalling pathways that regulate cell wall remodelling of Candida albicans MID1 CDC42 PMC4572872__F2 Many anticancer agents mediate tumour cell killing though activation of the BCL-2-regulated apoptotic pathway BAD BMF BAX PMC9650829__F2 Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside EGF LEF1 SOX2 EPCAM EGFR FHL2 CDH2 ADAM17 PMC9192945__F1 Myeloid Cells in GBM Immunosuppression CD14 CXCL1 BATF2 CD33 CD63 MMP9 CXCL8 IL8RB CCL2 HEL-S-26 CD80 FGL2 STAT3 PMC5639307__F7 Summary of the study results with pathway SUFU SHH SMO RAC1 PMC8708027__F6 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review ITGB3 BAK1 E2F2 EGFR CDK4 MCL1 SIRT1 CDK6 SOX4 PMC5012964__F3 Steroidogenic pathway HSD3B1 CYP11A1 HSD3B2 HSD17B2 HSD17B3 CYP17A1 CYP21A2 PMC8708027__F3 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review TSC2 BAD TSC1 MDM2 MTOR BAX PMC6323488__F3 Different signaling pathways related to EGFR activation induced by CTGF/EGFR interaction CDK2 EGFR CCNB1 CDC2 PCNA PMC5012964__F2 Molecular pathways underlying the development of the male external genitalia HOXA13 BMP2 FGF10 FGF8 SHH BMP7 HOXD13 BMP4 PMC4352987__F3 Multiple signaling pathways regulate the expression and activity of Sox9 during chondrogenesis NKX3-2 SHH GATA6 SOX5 COL2A1 GATA5 HIF1A SOX6 GATA4 SOX9 PMC4352987__F4 Different combinations of transcription factors drive tissue-specific gene expression in immature versus hypertrophic chondrocytes RUNX3 RUNX2 SMAD2 VEGFA GATA6 HIF1A GATA4 SOX9 MEF2D FOXA2 opn NKX3-2 FOXA3 SOX5 GATA5 ACAN COL2A1 SOX6 SMAD1 MEF2C DKFZp781O1323 COL10A1 PMC4352987__F5 Regulatory pathways downstream of BMP, Fgf18, CNP, Ihh or PTHrP signaling control chondrocyte proliferation and hypertrophy STAT1 PTH1R IHH NPR2 RUNX2 FGFR3 CCND1 CNP SIK3 FGF18 MEF2C MEF2D PMC9695474__F3 Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions STAT2 IRF7 IRF9 EGFR TRAF3 TRAF6 IRF3 MYD88 TLR3 TLR7 TYK2 IRF-1 MAVS PMC8389606__F2 NFKB and Human Cancer: What Have We Learned over the Past 35 Years? BCR CYLD RELB MYD88 LTBR PMC8708027__F1 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review EGFR GRB2 PTEN TGFA PMC7783549__F7 Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice BAD AIP CASP12 MEI1 CASP2 TNF DIABLO HTRA2 CASP3 ATF4 F3 CAD TRAF2 FADD PMC7196462__F2 Roles of SMAD3 in the TGF‐B and the BMP pathway SMAD2 DROSHA SMAD4 TF PMC3632646__F2 Regulation of GLI1 the isoforms by the canonical and noncanonical pathways SAP18 PDGFRA SUFU GSK3B MDM2 SHH SMAD4 SMO PMC5546320__F5 Oxygen Availability and Metabolic Adaptations ULK1 ATG12 ATG3 ATF4 BNIP3L BNIP3 BNIPL DKFZp686F0183 PMC12154332__F1 Barrel-like structure of ABO forms ion channels in the cell membrane, allowing Ca2+ to enter the cell NRF1 SRC TFAM SIRT1 PMC11605246__F8 Schematic explanation of the mechanism of action: the transformation into M2-like of spleen macrophages in patients with PH is activated, which in turn activates the Ras-Raf-MEK-ERK-c-Myc signaling pathway axis IL10 IL13 CD163 IL4 CD36 PMC12086986__F7 Magnolin mitigates CXCL10‐induced skin ageing CXCR3 CXCL10 GAL PMC12154332__F2 Serotonin and BDNF initiate neurogenesis HEL-S-11 PDK2 CDK5 BDNF PMC7843995__F5 CFMSN and associated drugs MYC VEGFA BCL2 MAPK1 IL6 PMC6825310__F4 Executable network model as seen in the BMA tool EGF BAD WNT1 MYC VHL PTEN COX2 MAX CDK2 MDM2 CDK4 MCL1 EZH2 BNIP3 ETS2 PMC8750045__F1 Tight Control of Non-Canonical TGFB Pathways and MicroRNAs Downregulates Nephronectin in Podocytes SMAD2 MAP3K7 SMAD4 TRAF6 ARHA MTOR TRAF4 PMC6912965__F1 Underlying mechanisms of Tregs in PAH BMPR2 CCND1 ARHA PMC6966641__F1 Major pathways involved in muscle loss in cancer cachexia SMAD2 MYD88 MTOR PMC10853679__F7 Graphical abstract to present metabolic heterogeneity in central and peripheral tumour areas of LumA and LumB EGFR LPL PIK3CA TYMS PDK4 PLA2G2A PMC7106581__F2 Graphic summary of physiological activities of Fndc5/Irisin that are elicited through pathways other than MAP-kinase signaling ULK1 TLR4 TRAF6 MSTN MYD88 MTOR BDNF HEL-S-104 STAT3 PMC7017070__F1 MiRNA processing pathway DGCR8 DROSHA XPO5 PMC5855561__F9 Working Model for regulation of prostate cancer AHR CYP1B1 CD84 IL1B PMC7757024__F2 SIRT1 regulates neuroendocrine secretion TH TSHR S100B SIRT1 PMC7757024__F1 SIRT1 modulates glucose metabolism through regulating cell secretion HEL-S-277 HEL-S-104 SIRT1 UCP2 PMC4090493__F6 Proposed mechanism by which -shogaol inhibits melanin biosynthesis MC1R TF PMC5716074__F7 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis PC LPA HEL-S-5 PMC6539782__F1 Carbohydrate and protein metabolisms EGR1 SLC7A11 PFKFB2 SIRT1 PMC8897051__F2 Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions MDM2 MTOR STAT3 PMC5716074__F1 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis GPT LPA LPP PMC2911501__F2 gp130-dependent cytokines promote axon regeneration and SOCS3 act as a critical negative regulator of the signaling pathway CNTF SOCS3 LIF IL6 IRS1 STAT3 PMC2911501__F3 PTEN-regulated signaling pathway TSC2 BAD TSC1 PTEN EIF4E MTOR BAX PMC7017070__F7 OncomiRs miR-221 and miR-210 and their impact on cancer cells CDKN1A PTPN1 MMP9 SMAD4 HOXA1 VMP1 SCD5 PMC7017070__F3 Important tumor suppressive miRNAs and their impact on cancer cells CXCR4 EZH2 PMC12007672__F8 Mechanistic illustration of KGF-2’s role in inhibiting inflammation and alleviating DED by regulating the HMGB1/TLR4 pathway NLRP3 HMGB1 TLR4 PMC3709783__F6 UV-induced cyclobutane dimers- structure (A) and repair by the Nucleotide Excision DNA Repair (NER) pathway (B) XPC ERCC5 ERCC1 XPA DDB2 PMC4955940__F1 T-cell activation is regulated by antigen presentation, as well as stimulatory and inhibitory co-receptors LCK ZAP70 CD80 JUN PMC6960141__F10 Proposed mechanistic model of FA-97 ameliorates DSS-induced colitis against oxidative stress by activating Nrf2/HO-1 pathway TLR4 KEAP1 IL1B NQO1 PMC8733961__F4 5q35 duplication presents with psychiatric and undergrowth phenotypes mediated by NSD1 overexpression and mTOR signaling downregulation TSC2 MTOR PMC2895369__F1 High-flux and low-flux systems of electron transfer pathways GPX4 GPX1 FES PMC8879487__F1 Utility of Genomic Testing for Hyperphenylalaninemia SPR TPH2 JDP1 PAH PCBD1 PMC5788639__F6 Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement BRAF IGF1 CCND1 PMC3061041__F1 Negative regulation of the IMD pathway POLE CYLD EGFR FADD PMC7611899__F1 Fibrosis development and signaling pathways TLR4 SMAD2 SMAD4 ADAM10 REL MTOR PMC5250671__F1 Oncogenic pathways in glioma and possibilities for pharmacological interventions, relevant for the models described in this article HEL-S-26 MDM2 GRB2 CDK4 PTEN RB1 MTOR PMC3757428__F2 Growth factors mediated mTORC1 and mTORC2 activation TSC2 TSC1 RHEB PMC3374088__F1 Caspase-8 has a crucial role in the regulation of DRs RIPK1 TRADD RIPK3 TNF FADD PMC8913526__F1 Helminth and Host Crosstalk: New Insight Into Treatment of Obesity and Its Associated Metabolic Syndromes TNF IL1B PMC11651451__F2 Oxidative stress and inflammatory response leading to CHD associated with SLE VCAM1 TNF PTX3 PMC11651451__F3 Initiation and activation of inflammasome of NLRP3, and the production process of IFN-I NLRP3 IRF7 IRF3 TNF PMC6170174__F8 The role of Piezo1 and Gq/G11 proteins in endothelial response to different flow patterns PDE4D PIEZO1 SRC PMC2042025__F3 Notch pathway is a frequent target of insertion NUMB PSEN1 CCND1 PMC9146692__F3 Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models STAT1 TLR8 TLR7 STAT2 TLR3 PMC8160512__F8 Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells IL6 CFTR PMC4444590__F1 Mitochondrial complex I dysfunction in patients with BD could lead to increased release of superoxide anions, resulting in greater reactive oxygen species (ROS) production NLRP3 IL1B PMC4613458__F2 Signalling to eIF4E in cancer RICTOR EIF4E MTOR PMC10095454__F6 The mechanism by which SDC3 cooperates with the regulation of milk fat synthesis and inflammatory response TNF PPARG SIRT1 SDC3 PMC11484321__F7 Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction TIAM1 TNC GHSR PAK1 CACNG2 VIPR2 CACNA2D3 HRC FFAR2 CASQ2 RYR2 ADCY9 PMC7796410__F2 Peptide-Based Nanomaterials for Tumor Immunotherapy HEL70 GEM CD44 PMC4192274__F2 Genes from the PPAR signaling pathway that were in regions surrounding QTL associated with at least one trait using the Bayesian approach FADS2 CYP4A22 CYP4A11 RXRA PMC5869700__F6 Toll-like receptor signaling pathway TLR5 CTSK IRAK1 MYC TRAF6 IRAK4 IL6 RAC1 MYD88 TLR1 MAP3K7IP1 STAT1 NFKBIA LBP UNK CD40 FADD TIRAP PMC4789659__F4 Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo DAPK2 HIPK2 HIPK4 HIPK1 DYRK2 PMC9294428__F4 Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks FOS SMAD2 ATF2 CDK6 RARA NFKBIA NR1i1 HNF4A TBP FOSB TFAP2A PPARG SMAD1 JUN PMC9536840__F7 Pathway impact and pathology of example disease genome-wide association studies (GWAS) hit IMPACT CAD PCCB PMC7020378__F9 Spatiotemporal metabolism in the apple fruit GIP ASPA PMC2743399__F3 Improved readability and performance with multi-scale information integrated in pathway visualization using metagraph NUMB MAML3 ATF2 CTBP1 DTX2 RASA2 GSK3B LFNG DLL3 RBX1 WIF1 HDAC1 DVL1 HES1 FST DCN CREBBP NFATC2 PSEN1 MAPKAPK5 GRB2 JUND PSENEN NCOR2 PMC2662565__F3 Bipolar disorder: from genes to behavior pathways MARCKS BDNF PMC4135953__F9 Network of genes in mice immunized with UV-V after SARS-CoV challenge IKBKE TANK TLR9 CFB IRF7 MYD88 SLPI TLR3 PTX3 PLAT MMP14 LIPG TNFAIP2 ADM SAA2 INHBA PMC9425297__F10 The role of FAM72A in SHM and CSR FAM72A MSH6 MSH2 UNG PMC11920859__F1 Gli pathway-targeted Co(iii) Schiff base complexes inhibit migration of basal cell carcinoma cells† SUFU PTCH1 SMO PMC8753429__AF1 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway HMGB1 TLR4 PMC6955127__F6 Effects of AMI (92 mg/ml) on the mechanism of Raw264.7 cells infected with influenza virus TBK1 IRF3 TLR3 PMC7934404__F2 GBPs regulate host antiviral innate immune signaling pathways STAT2 IRF7 GBP5 GBP7 IRF3 GBP4 MAVS PMC9456027__F2 Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging FGF21 FOXO3A IGFBP1 SIRT6 IGFBP5 SIRT1 PMC5041887__F6 Cell polarity signaling in the plasticity of cancer cell invasiveness DAAM1 APC ARHA PTEN VANGL1 SMURF1 CDC42 PMC5041887__F7 Cell polarity signaling in the plasticity of cancer cell invasiveness ARHA PTEN FMNL2 SMURF1 CDC42 PMC6372626__F6 Frequent genetic alterations in genes from angiogenesis pathway in UBC PLCG1 SOS2 FGF2 FGFR3 PLCG2 HIF1A MTOR HRAS FGFR1 FRS2 ERBB2 APP SRC ADGRG6 SOS1 PXN STAT3 PMC6856883__F3 The regulatory roles of lncRNAs in TAM by regulating classic signaling pathway MMP2 TRAF6 PMC6856883__F1 Regulatory roles of lncRNAs in TAM polarization STAT3 PMC1183194__F5 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin CASP3 BIRC2 CASP6 DFFB DFFA APAF1 CYC1 CASP9 APP CASP2 LMNA CASP4 PMC1183194__F6 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin CASP6 MAP2K4 DFFA DAO MAP3K7 RB1 JUN FADD FAF1 ARHGDIB PMC1183194__F4 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin HEL-S-102 STAT1 CASP3 BAD APAF1 CSK CYC1 BCL2 RAF1 TNF CASP8 STAT3 PMC2358953__F2 Network diagram showing the checkpoint response to uncapped telomeres RAD1 RAD17 RAD9A PMC4666900__F1 Simplified pathway diagram showing the Leishmania-APC and T cell interaction IL10 APC IRF3 IFNAR2 IL6 MTOR IL5 IFNAR1 IL6R IFNG STAT1 IL3 LCK STAT4 ZAP70 IL2 IL4 STAT3 PMC3064222__F9 Proposed signal transduction pathways in NG following receptor activation with leptin and CCK-8 HEL-S-62p ATF1 ARHA CCKAR STAT3 PMC7606273__F1 Autophagy and UPR pathways as well as their interconnection in SARC-CoV-2 pathogenesis ATF4 MTOR PMC6202145__F1 Structure of hRLX2, hypothetical pathway intermediates of RXFP1/2 and the benefits of hRLX2 therapy in radiation cystitis TIMP4 ARHA TGFB1 RXFP2 PMC521130__F2 Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts TH RPL18 GAL PMC8941799__F1 Myocardial bioenergetics in the healthy and in the diabetic heart OGT CPT2 HK2 HEL-S-162eP PMC3517581__F7 Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal SH-SY5Y Cells TAF9B HEL-S-89n MMD GFAP NFE2L2 IL6 GNL3L TNF LAMA1 BMPR2 APLP1 RECK BCL2 PEG3 C1orf21 PDE7B ELAVL2 PMC9247467__F3 CD44 In Sarcomas: A Comprehensive Review and Future Perspectives MMP14 SOX2 TWIST1 MMP9 CD44 ADAM10 ADAM17 PMC9220066__F3 Therapeutic Aspects and Molecular Targets of Autophagy to Control Pancreatic Cancer Management TSC2 ULK1 TSC1 MTOR DEPTOR RHEB PMC6292558__F2 Bioinformatic analysis of differentially expressed proteins (DEPs) identified in this study KRT19 NRAS EZR MMP17 MMP3 MMP7 COL11A2 RIMS1 HPGD MMP2 FAP LPL MAPK1 SCG2 MMP10 SNCA CHGB RELN MMP20 THBS4 GFPT1 VAMP2 TSHR POTEF SYNM CD36 AKR1B10 MAP2 DCLK1 COL3A1 DDC opn VWF SYN1 THBS1 CALCA MOS MMP16 COL4A2 COL4A1 SPARC PLIN1 RAB27A POSTN MMP11 PENK TMSB4X TIMP3 COL2A1 LAMC2 LOXL2 NAMPT CISD2 PPL SYN2 VCAN IGFBP7 MMP15 LAMB3 LAMB2 LAMA3 THY1 TNC LAMA1 RET MMP14 TIMP1 THBS2 TIMP4 THBS3 UNC13A VTN ENO2 CHAD TNR COMP CPLX2 BRAF EGFR PTPRN2 EEF1A2 HEL-S-104 PCSK2 XB COL4A4 SCG5 HSPB2 MMP24 MMP26 CD34 MMP9 STX18 DEHAL1 TG HEL-S-102 MMP12 LAMB1 VGF RAF1 STX3A PMC6151487__F5 Representative modules of ESCC-related metabolic network HEL-S-182mP HAO1 IDI2 BCAT2 GPT HADHB HAO2 IDI1 DBT ASPA PAH ACAT2 PC ABAT SPTLC2 ACLY FNTA HEL-S-133P AGXT2 PMC8298003__F22 Skin as a critical window in unveiling the pathophysiologic principles of COVID-19 HEL-S-62p VWF ACE2 TF PMC7939748__F2 Molecular mechanisms of plant-based foods in the alleviation of NAFLD KEAP1 MTOR SIRT3 PMC11892979__F1 Clinico-genetic Analysis of Adenosine Signaling Pathway in Drug-Resistant Epilepsy ADARB1 CREB1 MAPK1 NT5E ADK PMC7939748__F3 Molecular mechanisms of plant-based foods in the alleviation of AFLD CASP3 TLR4 KEAP1 MYD88 CYP2E1 FOXO1 BAX PMC7245796__F4 Metabolites on post-translational modification of EZH2 protein PDC PGM3 OGT EZH2 ACLY PMC5206726__F1 Relaxation oscillations and hierarchy of feedbacks in MAPK signaling NF1 NF2 EGFR PMC4023047__F3 Role of POR in biosynthesis of androgens in classic and alternate pathways FDX1 CYP11A1 HSD3B2 SRD5A2 POR HSD17B3 AKR1C2 CYP17A1 STAR FDXR HSD17B6 PMC5431431__F2 DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer IRX3 EGF PAX2 ACTA2 KRT19 SMAD2 TBX3 MYC CXCL8 HAND1 SOX17 DLX3 CCND2 PLAT KDR PPARGC1A MSX2 GREB1 JUN KLF6 SLC4A7 NPPA SOX2 CRABP2 PPL BMPER SKP1 ADRB2 KRT7 PBX1 IL6 GATA4 MYH6 LAMA1 TNC KLF4 IL6ST EPHA2 PPARG TGFB1 SOCS1 INHBA PMC5336163__F8 PAF-mediated endotoxin tolerance TLR4 SOCS3 IRAK1 TRAF6 MYD88 JAK1 STAB2 MAP3K7IP1 PMC7985098__F4 Effects of statin on NLRP3 inflammasome and TLRs pathways NLRP3 MYD88 CCS PMC3159112__F5 Ad signaling in endothelial cells ADIPOR1 ADIPOR2 TNF PMC6863963__F1 Conflicting roles of RASAL2 in different cancers TSC2 SOX2 GSK3B CD44 VEGFA IPO5 MTOR PMC5743757__F1 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets TLR8 CD14 TLR5 TLR7 TLR4 TLR9 LBP TLR3 TIRAP PMC5743757__F2 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets MYB IL6 RAN IL6R TIRAP STAT3 PMC7985098__F1 Roles of NLRPs and TLRs pathways in atherosclerosis pathophysiology NLRP3 MYD88 CCS PMC6997467__F1 Signaling pathway of ncRNAs in RA TRAF6 ECSIT MYD88 TLR1 MAP3K7IP1 PMC8225153__F4 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety CDK2 CCNB1 CDC2 MTOR STAT3 BAX PMC8225153__F3 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety APP ACHE TNF BDNF PMC5679744__F7 Fgf10-Hippo epithelial mesenchymal crosstalk maintains and recruits lung basal stem cells FGF10 CSA2 WNT7B PMC8446765__F1 Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer STS CYP17A1 PMC5447318__F2 Infection of virus can stimulate airway epithelium and produce antimicrobiota defense through IL-22/IL-22R signaling pathway TLR4 TLR9 S100A9 TLR3 PMC4155893__F3 Positive feedback loop between EGFR and ERA36.Notes: A positive feedback loop has been confirmed that EGFR signaling activates transcription of ERA36 through an AP-1-binding site in the promoter region of ERA36 EGFR CCND1 SRC PMC7907040__F2 Major signaling pathways of GPCR subfamilies PGC PMC4562327__F1 Transition of primordial to primary follicles KL BMP6 AMH WNT4 BMP15 FSHR FOXI2 FOXL2 PMC4064064__F3 MicroRNAs and Toll-like receptor signaling pathway in hepatitis B virus infection TLR7 TLR4 TLR9 IRAK1 TRAF6 IRF3 MYD88 TLR3 PMC8395432__F2 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection RP1 PARP1 TMPRSS2 PMC6528338__F5 An integrated gene interaction network built for genes related to wing dimorphism FBL GRWD1 RPL35 RPL27 RPL18 RPL4 SPTBN5 RPL30 PTEN NOP2 PPAN HIGD2A FTSJ3 RPL8 HEL103 RPL28 EIF3M LITAF RBM19 ALDH2 PMC8395432__F6 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection TLR8 TLR7 TLR4 TLR9 PARP1 ACE2 TLR3 TMPRSS2 PMC6442574__F1 Focal forebrain IR/IGF1R DKO eliminates signaling by receptor homodimers and hybrids in hippocampus or central amygdala IGF1R IGF1 IGF2 GSK3B GRB2 MTOR IRS1 PMC8205700__F4 Mesenchymal stem cell-derived exosomes: a promising vector in treatment for diabetes and its microvascular complications TLR4 SMAD2 ZEB2 VEGFA MTOR PMC8035080__F4 Mycolic acid biosynthesis and recycling INHA COCH PMC9330582__F1 Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer IMPACT TIGIT MTOR STAT3 FOXP3 PMC9659945__F1 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis ELF2 ID4 ATF4 PMC9659945__F2 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis EEF2 MYC MTOR PMC5976976__F4 Hypothetical diagram showing target sites for the action of curcumin (diferuloylmethane) in signal transduction pathway MAF IL16 KEAP1 APP BCL2 NQO1 PMC7594717__F8 Metabolic flux map for C CIT MAL PMC10450211__F2 Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression DKK1 ITCH PMC10509026__F1 Schematic view of vitamin D (VD) signaling pathway mediated VD receptor (VDR) FGF23 NR1i1 CYP2R1 CYP24A1 PTH CYP27B1 PMC9996228__F2 Genetic control of meiosis surveillance mechanisms in mammals SPO11 ATM ATR RNF212 BAX PMC10450211__F1 An Illustration of the circRNAs that directly or through specific miRNA sponges activate the Wnt signaling pathway and play a role in the progression of lung cancer NOVA2 PLAGL2 FZD4 TNF BIRC6 SOX4 KLF8 FGF7 ZNF124 PMC6854078__F8 Proposed schematic representation of the signaling pathways involved in the redox regulation of inflammasome activation in G6PD-deficient cells NLRP3 TLR4 HEL-S-44 IL1B PMC9581482__F8 Proposed model of LXR inhibition by oxysterol misbalance contributes to inflammation and fibrosis in murine WD ATP7B TIMP1 TG FASN PMC9252087__F2 PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes DCD PTS PURA PURB RPIA DUT ADK PMC4974116__F3 HCV dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy CTSS EFNA1 CXCL10 LCN2 CXCL8 SERPINB8 PHGDH SOX9 GBP1 UBQLN2 RRM2 BBC3 CCL20 CXCL9 TM4SF1 PSMB9 BAX PMC11652361__F1 Siglec-15 affects four key areas: bone metabolism, modulates infections caused by pathogenic microorganisms, immune regulation, and the pathogenesis of hematologic diseases CD44 TRAF6 COIL IL1B PMC9273851__F2 Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases GPX4 KEAP1 SLC7A11 DHFR FTL TFRC DHODH IPP PMC11652361__F2 Illustration of osteoclasts differentiation CD44 TRAF6 SYK PMC9626029__F4 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation LTA VWF ADAM10 PMC7653364__F4 Dysregulation of A-to-I RNA editing promotes cancer progression DHFR IGFBP7 GABRA3 PMC6994382__F2 Gene-network for genes mapped to 16 variants which replicated in both Hispanics and African Americans CLTB CD58 TMED9 CD46 IRF8 CCR4 CTLA4 IL12A TMED10 CR1 IL15 CLEC16A DEXI LMAN2 CFH CLTCL1 CLEC2D CD2 IL2 RNP24 IL15RA IL2RA PMC9626029__F3 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation BTK SYK PLCG2 PMC4976849__F1 Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis RFC1 ABCC3 GGH DHFR ABCC1 MTRR ADA MTHFD1 HEL-S-70p FPGS ABCC2 ABCB1 PMC7160326__F1 Different WNT signaling pathways DAAM1 DAAM2 APC GSK3B LRP5 LRP6 ARHA ROR2 PMC7160326__F2 The proteins that underlie Robinow syndrome or omodysplasia (indicated in red) in the WNT/planar cell polarity (PCP) pathway DAAM1 GPC4 RAC3 DAAM2 FZD2 NXN ARHA ROR2 GPC6 DVL3 DVL1 PMC7160326__F3 Modulators of the canonical WNT signaling pathway that are involved in the regulation of bone mass in human disease LRP4 APC WNT1 GSK3B LRP5 LRP6 DVL1 PMC1899878__F1 Regulation of dimorphism in C CAP1 NRG1 ECE1 PMC7269828__F1 Predictive biomarkers for PARPi efficacy CHEK2 PALB2 ATM BRCA2 CDK12 FANCA RAD51B PMC5328506__F2 Programmed cell death as a defence against infection RIPK1 TLR4 RIPK3 MYD88 FADD TLR3 ZBP1 MLKL BAX PMC5328506__F4 Programmed cell death as a defence against infection NLRP3 RIPK1 RIPK3 TNF IL1B FADD MLKL IFNG PMC4114189__F1 Molecular pathway of the mechano-induction of tenascin-C HEL-S-28 ARHA RHO MAL PMC4981669__F5 Possible mechanism for the antagonistic effect of Lpp and RNA in innate immune stimulation in monocytes and macrophages TLR8 IL18 TLR7 LPP MYD88 TLR1 TNF PMC7110195__F1 Nucleic acid sensors inducing type I and type III interferons TBK1 CGAS DDX1 DHX36 DDX41 MYD88 NOD2 MAVS PMC4981669__F4 Possible mechanisms for the synergistic immune stimulation of TLR2 and NOD2 ligands IL6 LPP MYD88 TLR1 PMC9261320__F1 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases ATF4 EIF2A TRAF2 XBP1 PMC2783518__F1 Wnt signaling and senescence: a tug of war in early neoplasia? LRP5 LRP6 PMC9261320__F2 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases ATF4 EIF2A C13orf34 TRAF2 XBP1 PMC2692400__F1 Hormone and nutrient signaling pathways modulating leptin translation TSC1 ELF3 TG IRS1 RHEB PMC5614756__F1 DJ-1 activates ERK1/2 signaling pathway TH HEL-S-44 PMC6154041__F3 The role of Wnt5a-Ror2 signaling in osteoclast differentiation PKN3 ROR2 RHO SP1 JUN PMC9207338__F1 Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases TBK1 CGAS TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR3 NLRP3 TLR8 TLR7 AIM2 IL1B IFI16 PMC5533708__F6 TANC protein interaction network TANC2 TNIK ZYX HEL-S-1 TANC1 SCRIB LATS2 PMC7348178__F6 VEGI‐251‐induced TAM apoptosis TRADD TRAF2 PMC6397982__F8 HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells COX2 IL16 LDLR PMC10977553__F6 Mechanism through which agarwood against RAS SOCS3 TRAF3 CCL5 CCL2 MMP3 CYLD JUNB CSF2 IRF-1 CASP8 FOS TNF EDN1 MMP14 VCAM1 TRAF1 CCL20 TNFAIP3 MLKL ITCH CXCL1 CHUK TRADD BAG4 VEGFD MAP2K3 NOD2 CEBPB RIPK1 ATF4 CXCL6 IL1B JUN SELE MMP9 PTGS2 LIF RIPK3 IFNB1 IL6 IKBKB CASP3 BIRC2 NFKBIA RELA DAB2IP PIK3CA CSF1 TRAF2 FADD IL18R1 PMC6834162__F2 Methotrexate (MTX) transporters, metabolic pathways and intracellular enzyme targets RFC1 GGH DHFR TYMS HEL-S-70p FPGS PMC3857329__F3 As discussed in the preceding sections, the catalytic activation method using HNTf2 allows efficient borylation with optimal substrates such as 22 TH NME2 PMC6834162__F4 MTX affects several signal transduction pathways implicated in the pathogenesis of rheumatoid arthritis (RA) IL15 IL2 IL1B IFNG PMC10560454__F1 tFNAs improve hUMSC chondrogenic potential through the regulation of the PI3K/AKT pathway ARHA ACAN COL2A1 MTOR SOX9 PMC8586713__F1 PTSD as an Endothelial Disease: Insights From COVID-19 PLG FURIN ACE2 BRD2 BRD4 PMC10508518__F5 KEGG simulated signaling pathway analysis XK OMD POLK APC CASP9 LAT MAL CBL PMC3545297__F1 Energy metabolism in a typical mammalian cell GAL PMC6784888__F4 Leveraging single-cell genomics to expand the fungal tree of life PC CP PMC8880811__F3 The Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas: An Update NF1 RET MTOR PMC3890531__F4 IGF signaling pathway BAD IGF1R IGF1 GRN STAT3 PMC6826966__F2 Mechanism of resistance to arsenic trioxide- all-trans retinoic acid (ATO-ATRA) therapy in APL RARA BCOR PML F2 ZBTB16 FLT3 TNF MTOR PMC9097844__F8 ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3B/Snail pathway driven by TGFB/Smad signals MMP2 MMP9 GSK3B PMC5110973__F4 Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta PDC GIP LPA ACD MME MAL PMC9593054__F2 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 TLR4 SIRT4 FOXM1 MTOR SIRT1 GSDMD PMC8774030__F1 Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/Beta-Catenin Signaling Pathway in Colorectal Cancer NOG APC NOTUM LRP5 LRP6 TNKS GPR49 LGR6 PMC6423768__F7 A schematic diagram of exosomal miR-128-3p based signaling pathway in CRC treatment TWIST1 BMI1 EZH2 PMC3931461__F1 Progress in molecular-based management of differentiated thyroid cancer BRAF PTEN MTOR PMC3506908__F4 Pathway analysis derived by comparison of the relative abundance of metabolites from sera derived from patients with locoregional CRC and liver-only metastases, as determined by GC-MS ITLN1 AEBP1 TREH HAS1 ZNF675 NRTN MAPK15 KSR2 G0S2 CXCL16 EDAR TFF2 MAPK4 AVP CAMK1D CLEC10A SPOCK1 PMP2 BPI CP RAB32 IL17B PMC3943494__F3 Ceramide Metabolic Pathway in Epidermis CERK SMS CERS2 PMC7503488__F1 Actions of metformin on immune cells, blood platelets and endothelium during the development of neurodegeneration disease: Metformin has multiple properties such as anti-inflammatory, antioxidant and antithrombotic properties PF4 VWF PMC9252100__F6 Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFA/NFKB Pathway IL1RL1 TRAF3 TNF PMC3848109__F3 TGF-ß fibrotic pathway PLG SMAD2 SMAD4 PMC9593054__F3 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 EGR1 TXNIP EZH2 MTOR FOXO1 GSDMD PMC3011942__F1 Phosphatidylinositol 3-kinase-Akt (PI3K-Akt) pathway becomes activated via stimulation of receptor tyrosine kinases (RTKs) and the assembly of receptor–PI3K complexes BAD PDK2 GSK3B MDM2 PTEN RAC1 MTOR CDC42 PMC9593054__F4 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 ELAVL1 KEAP1 GSDMD PMC5592666__F2 CoQ6biosynthetic pathway in S COQ3 COQ2 COQ6 COG7 COQ7 PMC9593054__F5 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 IGF1 CPT1A GSK3B EZH2 MTOR PMC9593054__F6 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 METTL3 DDX3X PTEN MTOR SIRT1 GSDMD PMC3112527__F3 Summary of the signaling pathway mediated by RET DOK4 DOK5 FRS2 GRB2 SHANK3 SRC GRB10 GRB7 PMC9550454__F6 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach BCR MYC MDM2 HEL164 SYK RAC1 CD19 PMC9550454__F7 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach SNCA BAD HEL-S-11 HEL164 APP NRBF2 PENK FADD PMC10622993__F2 Common signaling pathways and ALDH1 expression in CCA EBP SMAD2 APC TGFBR1 EGFR GSK3B LRP5 SMAD4 CDH2 MTOR PMC3279640__F1 Bi-potential gonad development to either testis or ovary DHH EMX2 NR5A1 LHX9 DMRT1 WT1 SOX8 GATA4 SOX9 FGF9 SRY FST CBX2 RSPO1 FGFR1 AMH WNT4 PMC2586270__F6 Furin action in pituitary gonadotrope cells SMAD2 FURIN PMC3279640__F2 Known genes and pathways of the different cell types of the developing testis in mouse (modified from Wainwright and Wilhelm ) DHH INSL3 WT1 SOX8 NOTCH3 FGFR2 GATA4 SOX9 CITED2 FGF9 HES1 SRY AMH WNT4 PTCH1 SF1 HSD3B2 SOX10 VNN1 CBLN4 PMC4772163__F5 Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm) MAPK13 DDC SHANK3 SPHK1 OXT MEF2C RAMP3 MYLK PMC3170587__F2 Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma LCK CREM SRC CRK CBLC PMC4330468__F1 Molecular targets and associated therapies to block three immunosuppressive checkpoints in a malignant brain tumor (glioma) model APC CD80 CTLA4 PMC11740643__F5 Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis SET CTSK CDK2 EGFR CYC1 INS APP SMAD4 PTEN KLF3 IFNG PMC8187562__F13 Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis NOTCH1 BCL2 PTEN BNIP3 MTOR SIRT1 FOXO1 STAT3 BAX HES1 PMC6822710__F1 Mck1 kinase is a new player in the DNA damage checkpoint pathway CDC6 HEL-S-84 PMC8512456__F2 Tumor immune microenvironment in epidermal growth factor receptor-mutated non-small cell lung cancer before and after epidermal growth factor receptor tyrosine kinase inhibitor treatment: a narrative review CXCL1 IGF1R HEL-S-28 SMAD2 EGFR CXCL2 PTEN CTLA4 CXCR6 FOXP3 CXCR4 opn CXCL6 RNF25 AXL STAT3 PMC6255705__F9 Schematic representation of metabolic reprogramming caused by the DAPAT mutation during diurnal cycle CS GAD1 D2HGDH PMC10551637__F1 Targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy SIRPA CD47 NPS PMC7301642__F5 ATG8-mediated selective autophagy pathways in plants PBR ORM1 NBR1 PMC8024584__F8 MAPK-signaling pathway with 5 selected genes (Ssk1, Pbs2, Ste11, Hog1, and Ssk2), known to be associated with response to osmotic stress SELL GPD1 CBL PMC4709637__F1 Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis CD14 DAO FLNA TRAF6 ERI1 NLK MAX GRB2 ECSIT RAF1 BDNF TRAF2 JUN PMC3227962__F5 Targets for intervention in the TGFB1 pathway (partial list) [, , ] ROCK1 RHO MTOR PMC7559222__F7 SNORA71A/mRNA/pathway interaction network constructed and visualized by Cytoscape software EPB42 LEP GGH RPS14 MRAP LBP ALAS2 HBB SNRPA AMY1A TNMD RPS21 PMC10607711__F2 Propagation of pressure in the epidermis and certain mechanotransducers involving the modulation of mechanical stimuli in keratinocytes TRPV4 CASR PIEZO1 PMC2875073__F5 Albumin alters TGFB pathway gene expression BAMBI EGF MAPK9 RUNX2 WNT1 MAPK3 TGFBR1 TGFBR2 BMP4 FKBP1A IFNG STAT1 FST NOG opn THBS1 SKI TGFBR3 JUN RUNX3 FOS LIF SMAD6 ENG TNF LTBP1 LEF1 CREBBP NFKB1 JAK1 SMAD1 DKFZp781O1323 INHBA STAT3 PMC3741150__F8 Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFA Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells TLR9 ECE1 TFAM PMC7762580__F1 Fructose and glucose degradation pathways ALDOB SORD AKR1B1 HEL-S-87p PMC2386920__F7 IRF-5 in the innate antiviral response TBK1 TLR7 TLR9 IRAK1 TRAF6 RIGI IRF3 MYD88 PMC7762580__F2 Fructose contribution to the pentose phosphate pathway ALDOB SORD AKR1B1 KHK HEL-S-87p HEL107 RPE PMC7708042__F4 DNA breakage formation induced by G4 stabilization FEN1 SSB DNA2 PMC4390799__F1 For therapeutic modulation of the UPR ATF4 EIF2A XBP1 PMC8904388__F1 Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments EBP RHO SLPI ARG1 PMC7699867__F2 Regulation between actin cytoskeleton and Yap/Yorkie at the apical cell cortex in Drosophila and in mammalian cells ARHGAP29 TRIO PMC11575037__F3 Figure shows selected subnetworks of the differential network for Liver tissue in Diabetes TMEM26 CCR2 NAPSA PRKCZ LY86 AGTR1 TRIB3 F2RL1 GCK CCL5 IFNG USP18 NLRP3 POMC CCR7 AIM2 GPER KCP LCN2 ATF3 NPPC CCL4 TNF NCR1 TBX21 CCL20 MERTK RORA ABCA1 CD248 TRPV4 MPO HGF CCR6 CX3CR1 ACACA DPP4 SIRT3 PCSK9 AMH SHBG DUSP14 STEAP4 TRPM2 ADAM28 SARM1 ARG1 ACE2 CD3E RORC PDE3B ABO RIPK3 NR3C2 NRG1 CD8A CYP2E1 AQP9 ADM2 TINCR STAT4 ADA NRG4 PPARG OSM MME AGAP2 GPR84 SOCS1 DNAJC27 CYP27B1 PMC5215839__F2 Posttranscriptional mechanisms of regulation of the miRNA biogenesis pathway DGCR8 TUT4 DROSHA PMC11575037__F5 Figure shows Selected subnetwork of the differential network for Aorta tissue in Diabetes TMEM26 CCR2 NAPSA PRKCZ LY86 DUSP12 TLR9 PAQR3 IL34 ATF2 TRIB3 FITM2 GCK AGTRAP USP18 NLRP3 POMC CCR7 LPL IRF-1 ANGPT2 DKFZp666G145 KCP LCN2 NPPC CCL4 TNF IRS1 TBX21 TRAF1 MERTK RORA ABCA1 IRAK3 SIRT1 MLKL DHRS9 ENPP1 EGF TRPV4 MPO HGF CX3CR1 EGFR DPP4 NOX4 BMP4 AMH ATM STS ARG2 SOCS7 LDLR TRPM2 ADAM28 ARG1 ACE2 IRF4 CD3E MAFB NLRX1 ABO RIPK3 NR3C2 NRG1 NR1C1 CYP2E1 TLR3 DCD ADM2 TINCR LIPE STAT4 ADA GRB10 FNDC4 DOCK2 OGG1 NRG4 OSM MME TIRAP AGAP2 PMC7803379__F1 Non-redox cycling mechanisms of oxidative stress induced by PM metals KEAP1 EGFR PRX HEL-S-162eP PMC8558403__F2 Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications TLR4 CCL4 CCL2 PMC3433910__F1 Putative scheme of the cellular metabolism in the hydrogen producing arachaeon T AIP PC PGP APRT PMC11575037__F7 Figure shows selected subnetwork of the differential network for Heart tissue in Diabetes NAPSA LIPE ATM ACACA ALB ADA CCL2 ADM POLM PMC9564177__F1 KEAP1-NRF2 System and Esophageal Cancer KEAP1 GCLC GSK3B PTEN NQO1 PMC1288546__F1 Human SHH-PTCH-GLI pathway (left) and its links to human diseases (right) GLI3 PMC4156318__F2 ATM-NFKB-regulated signaling network causing the adaptive resistance to IR in normal human skin epithelial HK18 cells ATM CCNB1 CCND1 PMC7387173__F3 Segregation of acute activity and cell transcriptional gene expression in POMC and NPY/AgRP cells POMC GHSR PC NPY AgRP TRPC5 LEPR INSR PMC4837871__F2 Sex-determining Region of Y Chromosome-related High-mobility-group Box 2 in Malignant Tumors: Current Opinions and Anticancer Therapy EGF SOX2 EGFR SMO ABCG2 STAT3 PMC12155444__F6 Composite Enzyme-Gene Network of Key Metabolites and Targets TH DGKD AGK UPP2 UGDH LTC4S TYMP BAAT DGKB DGKG PLD2 LAP3 DGKE RELA ADA DGKZ PMC9043895__F3 Corrigendum: The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation ME1 PALB2 ME2 SETMAR MBTD1 BARD1 HDAC1 BRCA1 tal-1 L3MBTL1 RNF168 PRC1 RNF8 HDAC2 RAD51 KDM2A VCP ME3 KDM4A PMC9569498__F1 O-GlcNAcylation in Renal (Patho)Physiology PGM3 OGA OGT PMC3607541__F6 Interleukin-1 alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil CCR2 TLR7 IRF7 CXCL5 IL8RB CCL7 CCL2 MYD88 PMC9310808__F1 Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cthGAMP TBK1 INA CGAS IRF3 PMC5609887__F5 Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer PLAUR SKIL MATN3 COL27A1 SNAI2 NRIP3 HBEGF ADAMTS6 JARID2 GLIPR1 COL1A1 CTHRC1 BMPR2 MAPKAPK3 FRMD6 INHBE PMC6072829__F7 Zyflamend and NFKB pathway UBC MMP2 MMP9 CCND1 PMC4263263__F2 Metacore analysis of leading edge genes CDC20 PLK1 APC SKP2 PMC4586784__F2 Modes of signaling in Hh pathway-dependent cancer HHIP PTCH1 SMO PMC4263263__F3 Metacore analysis of leading edge genes HEL-S-11 ATF4 MAPK14 ERAS TRAF2 XBP1 JUN BAX PMC9603940__F6 Microbe-Derived Antioxidants Reduce Lipopolysaccharide-Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1B Signaling Pathway NLRP3 SFN IL1B PMC7662987__F5 Schematic display of antitumor activity of CUDC-907 hybrid drug against prostate cancer cells RRM1 WEE1 RRM2 MYC PMC11602063__F15 ROS promote ginsenoside biosynthesis under water stress IPP HMGCR PMC5466420__F10 Illustration depicting the roles of Yap in submandibular gland epithelial development EREG EGFR LATS1 LATS2 KRT14 PMC8875669__F2 Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses SI DHCR24 SMO IPP SSR2 PMC9028838__F1 MicroRNAs: Novel Targets in Hepatic Ischemia–Reperfusion Injury MARCKS CXCR4 SMAD4 TRAF6 MED1 SIRT1 SOCS1 SIRT3 PMC8238121__F1 PARP Inhibitors in the Ovarian Cancer Microenvironment: Moving Forward From Synthetic Lethality TBK1 CGAS CXCL10 RAD51 CCL5 PMC8050411__F5 Enriched canonical pathways of the DEGs associated with the p53 signalling pathway identified by IPA, showing gene expression and predicted relationships between top regulated 311 nm UVB DEGs at 6 h and 18 h post-irradiation PAN2 TIGAR PML HP ATM PIGS PTEN JUNB ATR JUN PCNA BAX PMC11938626__F6 Oncogenic mechanisms of HBsAg mutants in hepatocarcinogenesis CDK2 VEGFA CDK4 SHB MTOR LHB PMC8050411__F6 Enriched canonical pathway of IFN transcriptomic pathway identified by IPA, showing gene expression and predicted relationships between molecules differentially regulated by 311 nm UVB 18 h after irradiation IFIT3 OAS1 IRF9 IFITM2 IRF-1 PSMB8 IFNG MX1 BAX PMC11938626__F2 HBsAg induces the HCC tumorigenesis by promoting proliferation APC GSK3B CCND1 SRC RAF1 PMC11938626__F3 Various oncogenic effects induced by the ER stress in the development and progression of HBV-related HCC FADS2 ATF4 VEGFA FGF19 SHB ACLY MTOR LHB TRAF2 XBP1 ACSL3 STAT3 PMC4392845__F1 13C Isotope-Assisted Methods for Quantifying Glutamine Metabolism in Cancer Cells HEL-S-26 CS FH OGDH GLS PMC4904011__F1 Protein pathway driving the migraine process at the tripartite synapse COX2 PRRT2 FHL5 SNAP25 ASTN2 MEF2D PMC3553975__F8 Subnetworks identified from (a) Loi et al RUNX1 MAPK8 TDG FOS RXRG DNTTIP2 STAT5B MAPK8IP2 STAMBP BCL6 GRB2 MAPK1 GRB10 PPARG JUN NCOR2 PMC3553975__F6 Subnetworks identified from (a) Wang et al UBE3A PML UBE2G2 POLD2 CCNA2 HDAC3 PGR TGFBR1 TGFBR2 CD44 MCM7 CDC20 PRC1 CDKN1A CDK2 SMURF2 CCNB2 TP73 BCL2 GMNN PCNA RBL1 PMC8704137__F4 Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It SLC7A11 HEL-S-64p HEL-75 SLC3A2 PMC9715766__F2 Gut microbiota, pathogenic proteins and neurodegenerative diseases NLRP3 CGAS TLR4 MYD88 PMC9245541__F2 How Do Pollen Allergens Sensitize? CD1D IL33 CD80 IL25 TSLP PMC1525234__F6 Working model of regulatory mechanisms controlling cell death in response to mating pheromones MID1 HMFT1766 GLS PMC5257007__F3 Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers FH PCCA PCCB MAL PMC3523822__F1 Biosynthetic pathway of diphthamide in eukaryotes DPH2 DPH5 DPH6 DPH7 DPH3 DPH1 PMC5040452__F13 Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis) TH CSF3 CXCL2 TNF CSF2 TGFB1 IFNG PMC3929252__F1 Estrogen, HER2 signalling, and the PI3K/Akt pathway in drug-resistant breast cancer.Notes: ER can activate gene transcription by nuclear translocatin following ligand binding (1) or as a result of receptor phosphorylation in the absence of ligand (2) BAD IGF1R GSK3B SRC PTEN PMC10296711__F12 Schematic illustration of the IL1-R/TLR/NFKB pathway with emphasis on activation of different NFKB subunits via the IRAK1/TRAF6-mediated pathway IRAK1 IRAK2 TRAF6 IRAK4 MYD88 IRAK3 TAB3 PMC10296711__F10 Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer TBK1 CD47 SOX2 TLR9 IRF7 IRAK1 IRAK2 MYC TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 AURKA TLR3 TLR8 TLR7 TLR4 KLK3 EZH2 IRAK3 PMC7174405__F1 Key proteins and important processes in vertebrate HH signaling pathway DISP1 SUFU PTCH1 SMO PMC2820748__F6 Sites within the early steps of the insulin signaling pathway affected by OGT and O-GlcNAcylation OGT SP1 STAT3 PMC7827067__F2 Pathway map of PIK3CA/AKT BAD MAPK7 GSK3B SHE PTEN HRAS CR1 PDPK1 CFTR MINK1 NFKBIA VBP1 MYO3B MYO3A ERBB2 CDK2 CDK14 RELA VTN GRB2 CDC2 CDK3 PMC5379071__F4 Proteogenomic integration reveals therapeutic targets in breast cancer xenografts PAH PMC7417632__F7 Hypothetical molecular mechanism of the H19/miR-29a/Wnt signaling pathway in HF inducibility of DP cells APC GSK3B LRP5 LRP6 DKK1 PMC2867902__F6 A feed forward loop for nutritional regulation of PNPLA3 PNPLA3 SCD ELOVL6 PMC4303448__F1 The IKB kinase complex in NFKB regulation and beyond CSA2 MAP3K7IP1 PMC8353268__F4 Quantitative developmental biology in vitro using micropatterning NPB NOG NODAL PMC8826716__F10 Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NFKB signaling pathway in lung adenocarcinoma TLR4 EGFR RNP24 PMC9310369__F1 Main mechanisms of mitochondrial DAMP signalling TBK1 CGAS CD1D MITA TLR9 IRF7 BAK1 P2RX7 APC RELB IRF3 IFNB1 TNF AGER ERAL1 RELA PANX1 IL1B TFAM MAVS BAX PMC4598605__F5 Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease GRB2 MTOR RHEB PMC4852538__F2 Pathway association between TH and metabolic process via ABCC8 (Kir6.2) (A) MAPKAPK2 FOS MAPK3 MAPK14 ATF1 ATF3 PRKACG FOXA2 FOSB SHH MAPK1 ABCC8 MAPK11 JUN SP3 PMC10311505__F3 YAP at the progression of inflammation TBK1 CGAS IRAK1 TRAF3 TRAF6 RIGI IRF3 MAVS PMC4970609__F10 Roles of hBVR in activating IRK/PI3K/Akt pathway IGF1 GSK3A BACH1 PMC6468556__F4 Model for HCV assembly and release DGAT1 ABHD5 DGAT2 APOE PMC3854349__F1 Biochemical adaptations of mammalian hibernation and naturally induced reversible insulin resistance PDK4 IRS1 PMC10033682__F3 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway CSK MMP11 WAS NISCH POR MATK HEL-S-69p RARA CNR2 MMP2 NR1B3 STK16 STS FURIN ACE2 PMC12180163__F13 Pathways of action of ESPs intervention to alleviate UC in mice EGF WNT3 IL33 IL25 TNF MUC2 PMC10033682__F4 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway BACE1 EGFR GSK3B NOX4 SAE1 DRD2 DRD4 PIM1 AHR SHBG MMP2 XDH CDC2 ABCG2 ADK CXCR1 MMP9 CCR4 GSK3A PTPRF MMP14 BCL2 MCL1 FLT3 MGA ALDH2 PMC3216306__F1 Downregulation of macrophages signalling by Leishmania infection TBK1 CD14 TLR4 IRAK2 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC6338098__F2 TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study BAD SMAD2 SMAD4 TGFB1 PMC4801794__F2 PI3K/AKT/mTOR signaling pathways TSC2 RICTOR TSC1 HEL-S-28 PTEN MTOR IRS1 RHEB PMC11435552__F1 Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses TBK1 IRF7 IRAK1 TRAF3 RIOK3 TRAF6 IRAK4 IRF3 MYD88 TLR3 ISG15 HP ISG20 GC MAVS PMC4158873__F2 O-GlcNAc and cancer metabolism SCO2 OGT ENO1 MTOR HEL-S-133P HEL-S-68p HEL-S-162eP GLS PMC5082879__F3 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models BTRC NPM1 MYC DOK1 PMS1 MLH3 C1QA NUFIP1 CDC27 TGFBR3 FRAS1 MYBL2 ITGB3 DNTT SDC1 SDC2 CHEK1 BRCA1 RFC4 CCT4 ADAMTS4 ERBB2 CCNG1 HEL-S-93 TRAF2 PCNA CP STAT3 PMC11435552__F2 DBV and GTV suppressing the IFN antiviral system by NS sequestration of key signaling molecules into IBs or FSs TBK1 STAT1 STAT2 IRF7 IRF3 TRIM25 MAVS PMC4158873__F3 PI3K/Akt/mTOR signaling pathway TSC2 RICTOR TSC1 OGT PTEN EIF4E MTOR RHEB PMC5082879__F2 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models FHL1 PBRM1 CENPF SPRY1 NR2F1 KRT23 CRLF1 SOX9 STAT1 SORL1 SLC7A2 DIRAS2 MAJN DNALI1 KCNN4 MFAP2 ZNF185 MYBL2 DUSP4 CRABP2 CYP1B1 SPRY4 HBG1 CENPE FGF13 SLC29A1 TG SPRY2 NEDD9 NCAPG RPS23 PMC10216404__F2 Effects of RSV on activation of SIRT1 signalling pathway RUNX2 NFATC1 MSC SIRT1 SOX9 PMC9007691__F6 Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer RAC1 EMP1 PMC12246835__F3 Underlying renoprotective mechanisms of anthraquinones by regulating IƙB/NF-ƙB, Keap1/Nrf2 and PI3K/Akt/mTOR signaling pathways TSC2 GCLM TSC1 KEAP1 GCLC OGT PTEN EIF4E MTOR RBX1 NQO1 RHEB PMC4471883__F7 TLR4 signalling pathway to alleviate microglial activation TLR4 BCL2 MYD88 IL1B BAX PMC10216404__F4 Effects of RSV on the regulation of microRNAs and BMP2 signalling in protecting bone RUNX2 BMP2 MSC NOX4 PMC12246835__F2 Underlying renoprotective mechanisms of anthraquinones by inhibiting TGFB1/Smad and Wnt1/Beta-catenin signaling pathways SMAD2 APC TGFBR1 LRP5 SMAD4 LRP6 PMC11172918__F4 Ouabain–NKA-induced changes in epithelial cultured cells MDCK TRPV4 SRC MTOR PMC8219020__F1 Live-attenuated oral polio vaccine as a potential source of protection against COVID-19 – Review of literature APC TIGIT CD226 PMC5625110__F1 Src family kinase signaling in renal fibrosis FYN EGFR SRC STAT3 PMC7583949__F2 Macrophages in cardiac fibrosis IL10 CD14 CCL4 NRG1 TNF PMC4564869__F3 Quantitative Phosphoproteomics Reveals Crosstalk Between Phosphorylation and O-GlcNAc in the DNA Damage Response Pathway OGT SCX PMC11172918__F3 Different signaling pathways activated by the binding of CGs and ROS to NKS EGFR SRC MTOR ORAI1 STIM1 PMC7549352__F1 miRNA biogenesis: the canonical pathway begins with the transcription of miRNA genes to form the pri-miRNA PAN2 DGCR8 PAN3 DROSHA ELF4 PMC6870983__F2 Schematic model of the mechanism of HuR-regulated tumor cell migration SNAI1 MMP9 EGFR UGDH RAB31 TGFB1 SIRT1 PMC6079259__F2 Mechanism of Homologous Recombination (HR) ATM RAD51 PMC4578617__F1 miRNAs that control signaling governing osteogenesis and adipogenesis BMP2 MSC SMAD1 PMC7864218__F3 Intersection of Mechanotransduction and Regenerative Osteogenic Materials NLK APC ARHA CDC42 PMC8532088__F2 Influenza virus RNA polymerase as an innate immune agonist and antagonist TBK1 RNF5 IRF7 TRAF3 IRF3 TRIM35 TRIM25 MAVS NBR1 PMC10755185__F6 Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes NAMPT EPO APP ADAM10 AGTRAP CFI BAX PMC2824768__F4 Entry into an ICL repair pathway depends on the mode of recognition REV1 XPC DDR2 MPG PMC8000576__F2 Mechanisms by which MYC induces apoptosis MAX APAF1 MYC MDM2 BAX BRD4 PMC8000576__F1 BCL-2-regulated apoptotic pathway BAD BIK BMF HRK BAX PMC8430060__F5 Gene expression patterns of neuronal cells reveal the pathogenesis of autism HLA-G EGFR VEGFA IL6 MME PMC3513217__F2 Schematic illustration of irinotecan disposition pathway UGT1A9 CYP3A4 APC ABCC1 ABCG2 ABCC2 ABCB1 UGT1A1 PMC3513217__F3 Metabolism pathway of tamoxifen and its interaction with estrogen receptors.Copyright © 2009 SULT1A1 CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP1A2 PMC9243258__F4 R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy ATM SETX SSB ATR H2AX BRCA1 PMC11556706__F1 Phase regulation of Ca2+-cAMP oscillation and corresponding mathematical modeling CSA2 AKAP10 PMC2666503__F1 F igure 1.— FRS2 GRB2 PMC9260753__F6 Network Pharmacology Experiments Show That Emodin Can Exert a Protective Effect on MCAO Rats by Regulating Hif-1A/VEGF-A Signaling TLR9 NR3A2 EGFR CA14 CA13 MAOA ALOX5 RIPK2 CYP1A2 CDK6 AHR KDR STS XDH ABCG2 BCHE AXL ABCB1 HEL-S-133P CYP3A7 NR1H2 CYP3A43 HEL-S-281 FASN CES2 CYP1B1 TNF CYP2E1 AURKB TNKS2 HEL-S-22 DRD3 CYP3A4 ERBB2 RELA LCK BCL2 CA5B PTP4A3 PMC4087671__F1 Control of the TRAF6 signalosome by miR-146a STAT1 IRAK1 CXCR4 TRAF6 IRAK4 MYD88 PMC7791871__F7 YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas LATS1 PTEN MTOR LATS2 PMC5548460__F1 Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape LMO2 PMC3423122__F10 Transcriptome of genes encoding enzymes and proteins on the lactose synthesis pathway, including GLUT1, HK1, PGM1, UGP2, GALE, GALT, SLC35A2, LALBA, and B4-GALT1, -3, and -5 LALBA B4GALT1 PMC3423122__F11 Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans STAT1 EPO PRLR SP1 IRF-1 CEBPB STAT3 PMC8217661__F2 Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells ITK APC CRKL PMC2483283__F2 Coexpression of genes within three core metabolic pathways ACP4 BCAT1 IVD ACP5 AGL PMC8267412__F2 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer GPC5 WNT3A PMC8267412__F3 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer PSD4 SDC1 ARF6 PMC6912266__F1 Potential intracellular target points for (i) acute alcohol and (ii) chronic alcohol in a stylized cell NLRP3 MPO IRAK1 LBP LTB RELB TRAF6 CD40 IRAK4 MYD88 REL PMC3860520__F3 Toll-like receptor (TLR)-4 signaling pathway in alcoholic liver disease TBK1 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC7687005__F8 Mechanistic diagrams indicate that in osteoporosis, miR‐497 could promote osteoblast proliferation and collagen synthesis, and inhibit osteoblast apoptosis through inhibiting LRG1 and activating TGF‐B1/Smads signalling pathway SMAD2 SMAD4 HMFT1766 PMC2483283__F4 Coexpression of the genes for fatty acid biosynthesis ACP4 ACP5 PMC6009972__F11 ML141-induced hepatocyte differentiation WNT3A ALB CDC42 PMC2483283__F5 Leucine degradation pathway in mitochondria MCC BCAT1 BCAT2 IVD PMC9607901__F3 Recent advances in the diagnostic and therapeutic roles of microRNAs in colorectal cancer progression and metastasis TRADD SMAD2 EGFR APC GSK3B SMAD4 PTEN TNF HIF1A MTOR CCND2 CCND1 MCL1 TRAF2 STAT3 PMC8908266__F1 Deubiquitinases in Virus Replication and Host Innate Immune Response TBK1 OTUB2 CGAS USP4 USP15 USP19 TLR9 TRAF3 TRAF6 USP49 MYD88 USP25 OTUD3 USP18 TLR8 TLR7 CYLD OTUD4 TLR5 OTUD1 USP27X USP2 IRF7 IRF9 USP20 IRF3 TLR1 OTULIN USP1 PMC7891831__F1 Enzymatic cascade of the renin-angiotensin system (RAS) and the key receptor systems ACE2 PMC5050041__F1 Neuregulin 1 - erbB4 pathway in schizophrenia: From genes to an interactome FYN DISC1 DTNBP1 RGS4 GRB2 SRC NRG1 AKAP9 PSD PMC10548138__F2 PI3K /Akt in COPD regulation IL6 TNF PMC4114321__F3 Regulation of homologous recombination in eukaryotes CIB2 ATM BRCA2 ATRIP RAD51 CLN3 ATR CIB4 PCNA CIB3 PMC10548138__F1 Transduction and regulatory pathways of PI3K/Akt pathway PDK2 PTEN INPP4B PMC6325760__F1 Schematic diagram showing PR/RANKL pathway and downstream RANK-mediated signaling in mammary epithelial cells EGF GIG8 EGFR CCND1 TRAF2 PMC6995173__F7 NAMPT’s role in the proliferation of human CRC cells through the regulation of Wnt/Beta-catenin signaling NAMPT APC PMC3189169__F1 Toll-like receptor (TLR) and type I interferon (IFN) signaling pathways TBK1 TLR9 STAT2 IRF9 TRAF3 IRF3 MYD88 TLR3 STAT1 TLR8 IFNA8 TLR7 TYK2 JAK1 PMC11786412__F7 Reconstruction the sex determination regulatory pathway involving amhr2 AMH HSD11B2 WNT4 AMHR2 DMRT1 PMC8195904__F2 Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis ZNRF3 RNF43 APC PMC8458763__F5 Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease PIEZO1 SMAD2 ANXA2 PMC6450552__F2 Systematic illustration of PGRN-mediated signaling pathways FOXO4 EPHA2 STAT3 PMC8392110__F1 Targeting STAT3 Signaling Pathway in Colorectal Cancer EGF SOCS3 SRC STAT3 PMC9496369__F1 Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives VCAM1 EGFR PMC9522619__F7 Properties of flavonoids in the treatment of bladder cancer (Review) NRBP1 MMP9 MDM2 FGFR3 CD44 HEL-S-53e PTEN TNF MTOR SIRT1 PMC6041267__F8 A schematic model of mitochondrial distribution regulated by the Arf6–AMAP1–ILK pathway TRAK1 TRAK2 RHOT1 HEL-S-28 PRKD2 ARF6 PMC9522619__F2 Properties of flavonoids in the treatment of bladder cancer (Review) GPX4 STEAP3 TRADD ATG101 TNF MTOR ATG14 FADD BAX PMC9522619__F3 Properties of flavonoids in the treatment of bladder cancer (Review) SOX2 SMAD2 PTCH1 GSK3B LRP5 SMAD4 SHH CCND1 LRP6 SMO STAT3 PMC9522619__F5 Properties of flavonoids in the treatment of bladder cancer (Review) PLK1 MMP2 FTH1 ATF4 SRC MTOR STAT3 PMC3412276__F1 Mannose metabolism in Trypanosoma brucei PMC9522619__F1 Properties of flavonoids in the treatment of bladder cancer (Review) PLK1 ATM CDK2 CDC2 ATR PMC3962548__F4 Controlling clot formation PC TFPI APC TF PMC3798018__F1 PLD and phosphatidic acid in the cell TSC2 TSC1 PC PLD2 GRB2 SRC RHO NME2 LPP MTOR RHEB PMC8329951__F6 Identification of differentially expressed genes in diabetic kidney disease by RNA‐Seq analysis of venous blood platelets IL5RA IL20RA DPYS LIF IL15RA IL2RA ddo CAD HDC PMC3354586__F3 Ingenuity pathway analysis (IPA) identified critical expression networks containing genes that are significantly correlated with the extent of necrosis in The Cancer Genome Atlas (TCGA) glioblastoma (GBM) samples from all subclasses (A and B) NPC1 PLAUR RELB CEBPB KSR2 ITGAM RNASE1 JMJD6 ZFP36 CD163 SLC2A3 S100A8 RNASE2 TNFAIP3 STAT3 PMC5027135__F4 A new model of MC4R microcircuitry POMC AgRP MC4R PMC5432127__F1A Maternal obesity on placental function and fetal development ADIPOR1 ADIPOR2 MTOR IRS1 NR1C1 PMC3275548__F3 Liver from Campari tomato treatment ITPR2 SLC1A1 PAX2 MGLL SMAD2 TGFBR1 KIFC1 YES1 RB1 MAPRE3 HEL-S-32 DPH5 NR2F2 FHOD1 FLOT1 BBS7 NR1B3 F2 E4F1 LDLR SREBF2 IL2 ANKH ARG1 IMMT ALDOB IL13RA2 MTX2 FARSLA APC TACC3 MTX1 MAPRE2 TNF FOXO1 HNF4A PDE4B RNPC3 DHODH PPARG LMO2 CACNB1 PMC3890531__F5 VEGF and NOTCH signaling pathways NOTCH2 FLT1 GC VEGFA NOTCH1 NOTCH3 PMC8448420__F2 Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword TRAF3 TRAF6 IRF3 ECSIT MTOR TIRAP PMC5362546__F2 Long non-coding RNAs in nasopharyngeal carcinoma: As systemic review RAB11A ARHA EZH2 PFN1 E2F3 RAB11B RAB10 PMC9496180__F8 Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor RHO LPA COL1A1 STAT3 PMC8259730__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction [Corrigendum] IL33 IL25 TSLP PMC2761106__F8 BMP7 signaling in the NZ ATF2 BMP7 ID1 SMAD1 DKFZp781O1323 PMC2743934__F8 Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD EEF2K EEF2 ARC PMC2990979__F1 Portions of the pathway utilized in Beta-branching are highlighted with color in this depiction of the bryostatin biosynthetic pathway C7 UNK HEL-S-5 PMC8346058__F2 Targeting Inflammation after Myocardial Infarction: A Therapeutic Opportunity for Extracellular Vesicles? NLRP3 CCR2 C1QA IGF1 IRAK1 TRAF6 S1PR1 MERTK MYD88 ADAM17 PMC7255381__F4 Signaling of the VEGF Ligands, Receptors, and the Inhibitors of the VEGFA Pathway PIGF NRP1 VEGFA VEGFB NRP2 PMC3427656__F1 GH-STAT5 signaling pathway IGF1 CDKN2B CDKN1A GHR PMC7016858__F1 Biogenesis and heterogeneity of tumor-derived extracellular vesicles AGO2 CD9 CD63 CD82 CD81 PMC7924189__F6 Mechanism of rice blast resistance in Tetep at cellular level MYB ERF LPO TF PMC3910266__F2 NOD1 signaling and interactions with Rho GTPases and NFATc NOD1 HEL-S-11 RAC1 RIPK2 CDC42 PMC7854028__F1 miRNAs participate in the regulation of key genes related to cellular response to IR ATM EGFR PTEN MTOR ATR PRKDC BAX PMC8931289__F9 Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism SALL4 MYB OMP SOCS3 GSKIP APLN MAPK3 CDKN3 TRAF6 CCNE1 PSMD7 FGFR1 A2M PIP4P1 AID MAPKAPK2 SPRED1 MTMR11 AK4 LSM11 RBM6 DGCR2 DESI1 CMC4 SDCBP2 RNF144B PLSCR4 FAM32A CACUL1 HLA-DQB2 HELZ PHKB ARL2 CDKN2AIP PTCD3 POLR3F GRB2 GRIN2B BCL2 TADA1 CYB561 HSPA1A CASP5 KDSR PNP AKT3 RORB TFRC CCND2 INSR TFCP2L1 NPR3 ENSA CRP CCND1 UNK CAMTA1 CDCA4 CD14 GADD45G HDAC8 FGF2 TMEM100 COXFA4 CHEK1 TNLG7A CLVS1 LBP CD40 MCL1 ARF6 SYDE2 TRAF2 SOCS1 STAT3 PMC12058831__F5 Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics GNPAT CHPT1 PMC2746747__F1 Molecular ablation of TGFB signaling pathways by tyrosine kinase inhibition: The coming of a promising new era in the treatment of tissue fibrosis SMAD2 TGFBR1 SMAD4 SMAD1 PMC5709847__F2 Regulatory mechanism of expression of DNA damage response genes by the checkpoint pathway PMC7854028__F3 IR-induced modulation of miRNAs initials carcinogenesis BCR PTEN BAX PMC5709847__F1 Checkpoint cascade in S PMC9393691__F4 Metabolic rewiring directs melanoma immunology AHR LAG3 FOXP3 PMC6113440__F3 Modified chlorambucil (Chb‐M') as a safe lead compound of novel anticancer drug therapy RUNX3 RUNX1 RUNX2 CBFB PMC9157603__F6 Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology TH REN PROB1 PMC6528848__F1 Different regulatory mechanisms of BANCR in different human malignancy NOTCH2 HDAC3 MMP2 TSHR EZH2 CDH2 PMC6639196__F4 Conceivable migration pathway related to PNETs based on literatures MMP7 PKP3 LCN2 MTOR CLEC3A PMC5532371__F8 A possible pathway for pre-miR-199a-mediated regulation of HSV-1 secondary envelopment ARHGAP21 ARF1 CDC42 PMC7730500__F1 Schematic diagram illustrating the steps and enzymes involved in the base excision repair (BER) pathway NEIL2 SMUG1 TDG BLM NEIL3 PARP1 PARG LIG1 WRN MPG NEIL1 FEN1 MBD4 SF1 PARP2 MUTYH OGG1 PNKP PCNA TDP1 PMC5922992__F1 Nucleotide-binding oligomerization domain 1-mediated mucosal host defense against Helicobacter pylori infection NOD1 IRF7 CXCL10 TRAF3 CXCL9 CXCL8 CXCL11 PMC7317091__F1 Summary of osteoclast differentiation induced by integration of CSF-1R, RANK, immunoreceptor-like and integrin receptor signaling VAV3 CSF1R NFATC1 GRB2 OSCAR TRAF6 SYK PLCG2 CSF1 PMC11492689__F1 Roles of non-coding RNAs (ncRNAs) in host response to PRRSV infection TBK1 SRP14 SOCS3 STAT2 IRF7 IRF9 IRAK4 IRF3 RAC1 TNF TLR3 STAT1 TLR7 CD151 CD163 TYK2 MAVS SOCS1 STAT3 PMC8501630__F5 Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors TSC2 TSC1 PC ELF3 RHO EIF4E RPS6 MTOR EIF4B RHEB INSR PMC11492689__F2 Roles of ncRNAs in host response to PRRSV infection IRF7 IFNAR2 IRF-1 AKT3 PMC9613904__F8 Proteostatic consequences of PKB/Akt-mTORC1 pathway manipulation in muscle ULK1 TSC1 IRS1 PMC11837477__F10 EGFR roles in fetal and postnatal pancreas development EGF BTC EGFR SRC HBEGF RAC1 MTOR ADAM17 PMC11010095__F8 The pivotal role of CTRP9 in reendothelialization of EPCs and the protective mechanisms of AMPK‐mediated Akt/eNOS signaling involved in adipoR1 and N‐cadherin receptor ADIPOR1 ADIPOR2 CDH2 PMC9355085__F3 Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity RICTOR VIT APC BIK TGFBR1 GSK3B SATB1 RELB MTOR DNMT3B IRF4 FOXP3 PMC11834966__F3 Action of PRMT3 and CARM1 in different cancer CDCA4 CARM1 GPX4 ST7 FACL4 NFIB LRRFIP2 VEGFA MYC PFKFB4 HIF1A MTOR CUL4A HEL-S-32 MPG HEL-S-162eP METTL14 TFEB PRMT3 GC YY1 EZH2 HEL-S-133P PMC6337236__F2 Iron handling in the tumor microenvironment EGF BMP6 HAMP LCN2 SMAD4 IFNG HEPH CD163 SMAD1 IL1B TF DKFZp781O1323 STAT3 PMC9198488__F2 Key Role of RNA Modification in Breast Cancer YTHDF2 IGF2BP1 DROSHA ENO1 STC1 KRT7 ALKBH5 WTAP IGF2BP2 AURKA YTHDF1 C5AR1 SMC1A METTL14 METTL3 IGF2BP3 GJA1 CDH2 PMC5727541__F4 2-hydroxyisobutyrylated enzymes involved in TCA cycle, pentose phosphate pathway, pyruvate metabolism, glycolysis/gluconeogenesis and starch biosynthesis pathways FH HEL-S-304 DLD RPIA OGDH HEL107 RPE DLAT SDHA HEL-S-162eP PMC11837477__F13 EGFR roles in lung fibrosis EGF AREG EGFR ADAM17 PMC4713620__F2 Model of RNF43-regulated p53 cell cycling pathway RNF43 MDM2 CCND1 PMC2955448__F1 Pathogenesis of prostate cancer: from molecular to metabolic alterations MAPK1 PTEN ACLY HMGCR PMC10539878__F3 Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease NLRP3 MFN2 PTMS CASR IL1R1 BRCC3 TNF PYCARD FADD MAVS GSDMD PMC2896848__F2 Alternate and peripheral androgen synthesis pathways STS CYP11A1 STAR PMC8465606__F7 Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino TLR4 TRAF3 UNK TRAF6 IRF3 IRAK4 MYD88 IL1B TRAF4 TIRAP PMC2784121__F6 NPM-ALK oncogenic tyrosine kinase controls T cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells VAV3 LCK VAV1 ZAP70 ARHA RAC1 LAT CDC42 STAT3 PMC12217521__F6 The paracrine effects of Mac-ADSCs HGF VEGFA PIK3CA IL11 IL6 PMC3131451__F1 The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays PTEN MTOR PMC10040407__F8 Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure TH GPX4 FACL4 PMC8792742__F2 Inflammasome Activation in Pulmonary Arterial Hypertension HMGB1 TLR4 IL1B GSDMD PMC9372260__F4 Integrated analysis of multiple bioinformatics studies to identify microRNA-target gene-transcription factor regulatory networks in retinoblastoma BRIP1 MCM7 CDC45 MCM3 CDC20 MCM6 MCM2 CDC6 RRM2 CCNB2 TYMS RAD52 GTSE1 PMC6522569__F2 Beyond PD-1 Immunotherapy in Malignant Melanoma IDO1 LAG3 PMC4413906__F2 Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus PGR SRC TF PMC6568338__F8 Adhesion-dependent and -independent pathways leading to DNA synthesis in ET-1-treated astrocytes GRB2 SRC RHO PMC9688773__F8 Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology PC DHCR7 DHCR24 PCYT2 HMGCR PEMT PMC10535041__F5 Antagonistic Activity of Oroxylin A against Fusarium graminearum and Its Inhibitory Effect on Zearalenone Production FH ACO2 HEL-S-304 RPIA PMC3621013__F5 Control of Alternative Splicing in Immune Responses: Many Regulators, Many Predictions, Much Still to Learn LEF1 CD44 CELF2 FASTK PMC2770326__F6 Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures GNE DPAGT1 GALK2 FPGT RENBP PMC12034657__F4 PI3K/AKT/mTOR signaling pathway activated by Sr CASR SP2 MTOR PMC2770326__F4 Pathway options for sialic acid glycoengineering GNE NANS COCH PMC7952251__F2 Regulatory mechanism of aromatase and '2-cell, 2-gonadotropin hypothesis' IGF1R IGF1 SMAD2 FSHR CEBPB PMC5864864__F7 Proposed model of the temporal contributions of Wnt ligands and Beta-catenin to Alpha-galactosylceramide (Alpha-GalCer)-induced interferon gamma (IFNG) and IL-4 responses by liver natural killer T (NKT) cells APC SFRP1 DKK1 PMC9539487__F4 Partners in crime: Proteins implicated in RNA repeat expansion diseases ELAVL1 EIF2D EIF2A EIF3B DHX36 RAN CAPRIN1 PMC4443896__F1A Activation of the JAK/STAT pathway in Behcet’s Disease GRB2 MTOR GAST CEBPB PMC11595439__F3 The CWI signaling cascade RHOT1 ATF1 COIL SP1 HMFT1766 PMC3500439__F1 Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor Alpha as a Therapeutic Target in Cancer TSC1 IGF1 YY1 IL4 MTOR PMC7911116__F2 Lithium interactions with oxidative stress, inflammation and glutamatergic pathways GSK3B BCL2 BDNF PMC2871634__F5 Regulation of apoptosis PAK1 TRADD CAD TRAF2 FADD PMC8157630__F6 Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis RHO CAD OTP LAT CDC42 PMC4319431__F1 Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions FUT6 GALNT3 TRAF2 FADD BAX FUT3 PMC7911116__F1 Activated and deactivated WNT pathway APC GSK3B LRP5 LRP6 PMC4085981__F1 Positive feedback in cardioprotection: Can more mechanism lead to translation? RICTOR PC RPS6 MTOR PMC2620272__F4 Bimodal genes that were switched "on" as a result of HIV infection in KEGG T-cell receptor signalling pathways CDA ITK APOM FYN DAO LCK CTLA4 LAT CRB2 CD36 PMC3071786__F6 Changes in mRNA levels among various signalling pathway members following inhibition of FGFR activity FGF4 GPC4 SNAI2 SPRY1 XBP1 FGF3 FRS2 ATF4 TBX6 FZD7 SNW1 FZD10 ELK3 PDGFRA HDAC8 APC NOTUM ATF3 ARHA FZD4 FGF18 SPRY2 WNT3 CREBBP EDNRB GRB2 TBX4 ZIC3 CDX4 AKT3 FZD8 POU3F1 PMC9251686__F7 Receptor interacting protein 1 knockdown induces cell death in liver cancer by suppressing STAT3/ATR activation in a p53-dependent manner RIPK1 TOPBP1 ATR STAT3 PMC6527808__F1 Molecular pathogenesis of Epstein-Barr virus-positive NK/T-cell lymphoma HACE1 FOXO3A PTPRK MYC DDX3X ECSIT PMC8416054__F2 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease TLR9 FCGR2A IRF7 IRAK1 CSK CTLA4 MYD88 TNF BLK PTPN22 ITGAM PDC TLR7 CD72 RASGRP3 STAT4 LYN CD40 LILRA2 CD80 TNFAIP3 PMC8416054__F3 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease TRAF1 CD44 TRAF6 CD40 CD80 PTPN22 FOXP3 PMC2819165__F2 Genetic Susceptibility to Lymphoma IL10 NFKBIA LEP TLR4 CCND1 BCL2L1 IL6 TNF IL10RA CCND2 PMC2770326__F2 Mammalian sialic acid metabolism ST6GAL2 GNE NEU2 NEU4 ST3GAL3 NEU1 PGM3 ST8SIA4 ST8SIA5 ST8SIA6 ST8SIA2 ST8SIA1 ST3GAL6 SIAT4C KL CMAS NANS NEU3 GNPNAT1 ST6GALNAC4 ST3GAL1 ST6GALNAC2 NANP ST6GAL1 PMC11058230__F7 A hypothetic model for signaling pathway alterations and cellular phenotypes in MPS II neurons MMP7 FOSL1 KCND2 AXIN2 SCN9A CACNA1A P2RX3 NEFL PMC5861197__F3 Paradigm of host inflammation responses to Salmonella and its interaction with autophagy as well as ubiquitination NLRP12 TRAF3 TRAF6 MYD88 IL1B PMC8168445__F1 Reactive astrocytes are a key component to neuroinflammation in AD FOXO3A EBP STAT3 PMC5861197__F4 The similar activation process of autophagy and NFKB pathway in response to Salmonella SHARPIN OPTN OTULIN PMC5343350__F7 Potential mechanisms involved in T helper type 17 (Th17) differentiation under T‐bet over‐expression conditions AHR RUNX1 IRF4 IFNG PMC6873406__F9 Non small cell lung cancer KEGG pathway FHIT BAD RASSF1 DAO ERBB2 POLK EGFR CASP9 JAK3 BAX PMC3366822__F7 Schematic diagram showing the role of NDRG1 in inhibiting the EMT via regulation of the TGFB/SMAD and Wnt pathways SMAD2 SMAD4 CCND1 PMC3851951__F4 Microbiota impact on the epigenetic regulation of colorectal cancer LTA RUNX3 TIMP3 PMC6767051__F2 Cell cycle‐non specific mechanisms for the resistance to CDK4/6 inhibitors CDK2 SMAD2 ZEB2 SMAD4 CDK4 PTEN MTOR CDK6 PMC7408838__F2 SRC-mediated molecular pathways formally assessed in malignant mesothelioma (MM) POSTN CCND1 SRC CDK4 CDK6 STAT3 PMC2871634__F4 WNT/Beta-catenin signaling pathway APC GSK3B CCND1 FRAT1 FRZB PMC7819563__F3 Correlation between glucose metabolism and amino acid metabolism in tumor cells HEL-S-26 GPT2 ASS1 HEL-S-133P PHGDH GLUD1 PMC6333678__F2 Signaling pathways activated after binding of E2 and G1 to GPER EGF EGFR CCND1 SRC PMC5809440__F2 Assessment of liver microenvironment through whole-genome RNA Seq IFIT3 TBK1 IFIT2 IRF7 IFITM3 TRAF3 EIF2AK2 IRF3 MYD88 MAP3K7IP1 IFI44 ISG15 OAS2 OAS3 STAT4 CD80 IFIH1 IFIT1 PMC11294417__F10 Schematic diagram for NEK2 functions during porcine embryonic development APC LRP5 MYC LRP6 MRE11A CHEK1 BRCA1 CHEK2 CDK2 CCNB1 NEK2 CDC2 PRKDC PMC6245977__F1 RAS signaling pathway with proteins mutated in JMML in red GAB2 GRB2 MTOR CBL PMC7281231__F7 Schematic representation summarizing the impacts of PEDV ORF3 on NFKB and IFNB signaling cascades TBK1 IRF7 RELA IRF3 IL6 MAVS PMC6632210__F7 LPS-mediated platelet activation and TLR4 expression in canine platelets CD14 TLR4 CS COX1 LBP PMC7343769__F1 Molecular mechanisms of chloroquine/hydroxychloroquine in pDCs CGAS TLR7 TLR9 IL6 CD80 MYD88 TNF MAVS PMC9320269__F4A Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects CORT HLA-A HLA-B PMC7488754__F1 Scheme of processes that maintain a certain receptor density on the postsynaptic membrane at the activated synapse TSC2 TSC1 SHANK3 RHEB PMC8347170__F2 Autoimmune Responses in Oncology: Causes and Significance CD80 PMC3992631__F3 Comparison of gene expression in immobilized relative to planktonic yeast: (A) intermediary metabolism and (B) cell cycle HEL-S-26 PDC ACO2 ENO1 ENO2 ADH5 CDC34 HEL-S-32 HEL-S-4 MDH2 HEL-S-68p PMC10526805__F3 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes IQGAP1 PMC10526805__F2 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes LAPTM4B MAP4 EGFR DAB2IP IQGAP1 PTEN ARF6 ARF1 NEDD4 PMC8470522__F3 Actions and Roles of FSH in Germinative Cells LIN28B RET BCL6B ID4 GDNF BCL2 FSHR BMP4 PMC4685420__F1 Schematic summarizing some of the genes and pathways known to influence c-Myc cap-independent translation in multiple myeloma (MM) RPS25 IGF1 IL6 MTOR PMC7819563__F2 Metabolic alterations in hepatocarcinoma CUEDC2 OXCT1 HEL107 HEL-S-133P PMC9424728__F9 Integrating physiology, genetics, and transcriptome to decipher a new thermo-sensitive and light-sensitive virescent leaf gene mutant in cucumber UROD UROS CPOX POR PMC4694793__F3 Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy HGF EGFR BCL2 SMO PTEN MTOR PMC7841926__F4 Illustration of the calcium signaling pathway induced by major putative targets of SMT PLN CAV3 CAV2 PMC12203940__F1 Wnt signaling pathways APC LRP5 LRP6 ARHA RYK RHO PMC4964175__F1 Pharmacological targets of ibuprofen HEL-S-62p RGMA ARHA PMC5890536__F9 RFc constructs on human complement HEL-S-62p C4A CP PMC8106045__F1 Physiology and pathophysiology of copper transport and metabolism ATP7B ATOX1 CP PMC4227521__F1 Erythropoietin receptor and signaling pathways STAT1 EPOR EPO GRB2 SHE BTG1 STAT3 PMC3980740__F5 Signaling circuit driving transformation and tumorigenesis SRC IL6 NOTCH3 STAT3 PMC1782564__F6 Hypothesized asthma cascade in hapten immune contact sensitized mice, consist of B-1 cell- to immunoglobulin M- (IgM) to complement-driven airway responses CS AHR PMC4553261__F1 Data slicing and pathway enrichment analysis COX2 SET APP PMC9654339__F3 In Vivo Models for Prostate Cancer Research ERG NSD2 SPOP PTEN PMC9654339__F4 In Vivo Models for Prostate Cancer Research MYC MDM2 ACSS3 PTEN BRCA1 HOXB13 PMC9654339__F5 In Vivo Models for Prostate Cancer Research MMP7 BRAF MAX ALK APC FZD2 MYC PTEN RIPK2 STAT3 PMC4653709__F12 Proposed schematic representation showing the mechanism of ETH and its effect on neurogenesis APC GSK3A PMC11950527__F3 Annotated map of EM on PCa-related signaling pathways TH POLK TRAF3 LCN2 CCL7 CCL2 USP25 S100A7 MMP3 CCL20 FLT3 TRAF2 FADD PMC7603200__F4 Connection between the PI3K/AKT/mTOR pathway and GLI activity GLI3 GSK3B PTEN DEPTOR RHEB PMC8281607__F2 Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation GNPAT FAR1 TMEM86B PEMT PMC11854706__F6 Signaling pathways induced and inhibited by ACE PIK3R1 BAD TRADD PARD6G EGFR PARD6B GSK3B PTEN CCND3 CCND2 APAF1 CASP9 CCND1 PARD6A AXIN2 CASP8 PARD3 APC RAC1 TNF CASP10 CASP3 AXIN1 PIK3CA BCL2 FADD CYCS PMC8467449__F3 Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer PCSK9 LDLR SREBF2 SOAT1 ABCA1 CYP17A1 HMGCR PMC4198363__F5 A role of autophagy in PTP4A3-driven cancer progression SQSTM1 MTOR DKFZp686F0183 PTP4A3 PMC7603200__F2 MTOR pathway GSK3B TBC1D7 PTEN EIF4E CAD DEPTOR MTHFD2 RHEB PMC7286374__F3 Primary pathway of steroidogenesis and enzyme inhibition by posaconazole (P) CYP11A1 CYP17A1 CYP21A2 STAR CYP11B2 PMC8505360__AF1 Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis ULK1 HEL-S-44 MTOR ATG14 PMC12211798__F7 Proposed model of IGF2BP3 joined in autophagy mediated TNBC metastasis with m6A-dependent molecular mechanisms AAG1 MTOR PMC7275878__F1 Genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity TLR5 TLR7 TLR9 IRAK1 SHARPIN TRAF6 MYD88 TLR1 IRAK3 TLR10 IL1B TIRAP PMC3508562__F1 Diagram representing the possible endogenous and exogenous TLR activation pathways and the accompanying response.Abbreviation: TLR, toll-like receptor TLR4 TNLG7C PMC3508562__F2 Genomics in cardiovascular diseases: analysis of the importance of the toll-like receptor signaling pathway TBK1 CD14 TLR5 TLR9 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TIRAP PMC11206721__F1 Nutrition-related signaling pathway leading to diabetic nephropathy FOXO3A MTOR NR1C1 SIRT1 ELMO1 SIRT3 PMC6241696__F4 Regulatory network of FSH to cervical cancer CASP3 GSK3B FSHR PMC9576970__F2 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach PLVAP PRODH PMC4127169__F2 Wnts organize presynaptic (CNS and NMJ) and postsynaptic (NMJ) specializations through multiple signaling pathways MUSK GSK3B RAC1 PMC9576970__F3 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach CXCL1 ABCG5 SREBF2 CXCL8 NPC1L1 SP1 CXCL11 PMC9404373__F1 Metabolomics in rheumatoid arthritis: Advances and review PDC PC MMP9 IL1B FGFR2 HK2 STAT3 PMC9576970__F4 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach SLC3A1 CXCL1 PTGS2 IL8RB IL6 TNF IFNG STAT1 MMP7 NFKBIA MMP12 JUN IL1B STAT3 PMC8119379__F2 De-coding genetic risk variants in type 1 diabetes UBASH3A NOD2 IFNG STAT1 IL18 IL2 CD47 CXCL10 APC ABO IRF3 CTSH IFNAR2 IFNAR1 hCG_1998026 TLR3 CBL PLN SIRPA LCK ZAP70 TYK2 CD80 JAK1 CD226 PMC5226501__F1 Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease LATS1 LATS2 PMC6967385__F2 Mouse gene expression affected by biofilm status UBC PLTP AQP7 HEL-S-28 LPL CPT2 PMC261890__F8 T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression ITK LCK SRC MTOR LAT PMC3583110__F2 Intrinsic and extrinsic apoptotic pathways TRADD FADD BAX PMC7086359__F6 Concerted effects of iAs-induced Nrf2 and HIF1A on glycolytic metabolism ENO3 HEL-S-30 CTRL ENO1 HEL-S-87p HIF1A HEL107 PFKP PGAM1 HK2 HEL-S-68p HEL-S-162eP PMC9144327__F3 Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials ACVR1 KIP75 EZH2 PMC6862519__F3 Schematic model AQP3 CASR AVP AQP2 AQP4 PMC8080978__F5 Pathways enrichment of Walktrap modules BIRC2 EPO STAT2 BIRC3 TRAF3 GRB2 PTPN11 MAP3K14 RHO FLT3 MTOR TRAF2 PMC8080978__F3 GO and Pathway enrichments of the PPI network HHIP DGKD GNA14 MYC H3F3B CPQ PTEN FLRT2 RGMB CEBPB CRKL DMD ANKRD1 ERBB4 BIRC3 LTBP2 APP MAFG CREB5 IL1A CALCA CLDN1 SPRY4 EHD1 PTGS2 MAP3K7 VEGFA GNA13 IL6 TNF FAT4 RCOR1 CBL CD151 AK3 H3C8 TNFAIP3 PMC10379484__F2 Endothelin-1 in Health and Disease EDN1 LAMP2 VWF CD81 PMC8080978__F9 Hypothesized mechanism of action of downregulated ERBB4 in SARS-CoV-2 infected cells ERBB4 APC EGFR TMPRSS2 PMC5880643__F1 Peripheral complement interactions with amyloid B peptide (AB) in Alzheimer’s disease: 1. Erythrocyte clearance of AB HEL-S-62p C4B_2 C1S C4A PMC8034193__F4 Calcium (or Ca2+) signaling pathway in T PLN PI3 BCR HRC MCU CAV2 SLC25A4 TRDN CCKBR CALM1 PMC9674149__F7 Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway map ChAT PMC8081888__F4 Metabolic Landscape for Maintaining Retina Integrity and Function RPE HEL-S-281 MAL PMC4061475__F1 Dopamine biosynthetic pathway TH PAH PMC3770583__F7 Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice PAK1 BAD CCND1 CDC42 PMC5416929__F8 Working model of TGFB and NFKB pathway interactions that regulate GCT viability SMAD2 PMC4132962__F1 Protective mucosal immunity mediated by epithelial CD1d and IL-10 APC STAT3 PMC4001311__F6 Schematics of the regulation of the HMOX1 expression under normal (a and b) and stress conditions (c and d) and without (a and c) or with (b and d) BRD4 knockdown KEAP1 SP1 MX1 BRD4 PMC10539950__F2 Innate immune signalling in response to cytosolic DNA and DNA damage TBK1 CGAS ATM CXCL10 CCL20 RELB TRAF6 IRF3 CCL5 IFI16 PMC3621569__F6 Planar cell polarity pathway (PCP pathway, non-canonical pathway) cascade DAAM1 ARHA CELSR1 PMC9254110__F7 FOXF2 oppositely regulates stemness in luminal and basal-like breast cancer cells through the Wnt/beta-catenin pathway HDAC3 NCOR1 BCR FOXF2 FZD1 TF PMC3010226__F2 Cellular and molecular scheme for an adaptive immune axis leading to acute lung disease after viral infection TH CCR5 PDC FCER1A AHR CCR10 CCR7 CCL19 PMC5507681__F8 Signaling pathways involved in keratinocyte growth and differentiation that are perturbed by SbIII and AsIII EGF LRIG1 EGFR NOTCH1 KRT1 FOXN1 PMC9664671__F1 HOXA9 in solid tumors: mechanistic insights and therapeutic potential ULK1 SOX2 HOXA9 ATG12 RUNX2 FOS BCL2 CYBB MTOR JUN IRS1 HK2 PMC7960940__F7 IPA network analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 1 of the 148 differentially expressed protein panel IL13 FOS PTGS2 ENG GATA4 PLCB1 DGKA BCL6 GPX3 TFPI2 C1QB TNFSF11 IGLL5 IL-21 GATA3 CD3E PMC7960940__F8 IPA networks analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 2 of the 148 differentially expressed protein panel TNFSF8 IRF7 IL13 F8 F9 IL6 SAA1 S100B AGER F2 F5 SATB1 VWF HBB CD40 JUND MCL1 GP1BA TAF8 CCL3 PMC6482478__F1 Basic mechanisms of lithium function GSK3B CHN1 IPP PMC7171331__F7 LGR6 KEGG pathway NLK DAAM1 INVS SIAH1 STOM APC SOST NOTUM SMAD4 SKP1 ARHA RYK PMC5008685__F2 Mechanisms of initiation of translation ELF5 ELF3 ELF1 SUI1 ATF4 EIF2A EIF5 PMC5008685__F1 PERK-dependent Unfolded Protein Response ATF4 EIF2A CCND1 PMC12081606__F7 Working model NRF1 FUNDC1 BNIP3L PMC5008685__F4 CHOP-induced apoptosis under prolonged ER stress ATF4 EIF2A ERO1A DDIT3 PMC6008457__F1 Reaction scheme of the metabolic sub-model INS GIP LPA GAL GRAP MAL PMC5866223__F3 Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension KY RHO PMC6406535__F1 Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages SFN DKFZp781B1423 MAPK14 PTEN RCHY1 CCND2 CCNE1 CHEK2 SIAH1 PERP SESN3 ATM SIRT6 MDM2 CASP9 CCND1 ZMAT3 CASP8 BAX STEAP3 CHEK1 CASP3 TSC2 IGF1 CDKN1A PPM1D CCNG1 ATR GTSE1 PMC6083633__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC EGF LRRK2 IGF2 EGFR HBEGF ARF6 BLK GPNMB PMC6261981__F2 Potential mechanisms involved in propagation of Alpha-syn TH NLRP3 RNF11 MPO MTOR IFNG PMC9633631__F3 Lung fibrosis: Post-COVID-19 complications and evidences MMP7 MMP14 APC TF PMC6103439__F5 Homeostasis, regeneration and tumour formation in the mammalian epidermis MMP2 GSK3B IL6 PMC9633631__F4 Lung fibrosis: Post-COVID-19 complications and evidences BIRC5 AREG LATS1 AXL LATS2 PMC5069085__F1 Integration of lipid homeostasis into the macrophage host defense response TLR4 MARCO IL1B PMC11502746__F6 Selected impacts of MGO exposure in SH-SY5Y cells NDUFS4 GCLM UQCRB NDUFB4 KEAP1 NDUFA7 COQ6 ENO2 PFKL IDH3B HMOX1 ATP5F1D PMC3416758__F7 TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells FOS ATF2 BAX PMC3148248__F5 TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding CD14 HMGB1 TLR4 LBP IRF3 IRAK4 RAC1 MYD88 TIRAP PMC8495178__F8 N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells METTL4 PMC6489264__F1 Dauer signalling pathway model proposed for Haemonchus contortus PPM2C INS SGK1 NCR1 NCR2 PMC1839891__F1 Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery SMO PMC2776723__F6 Integration of activated transcription factors with the upstream signaling network during CB1R-induced neurite outgrowth MYB RUNX2 CREB1 CEBPA POR THRA STAT1 HIVEP1 NR1i1 STAT4 SRC NFYA STAT3 PMC7588666__F1 Base excision repair and its implications to cancer therapy FEN1 PARG LIG1 UNG OGG1 PNKP PCNA NEIL1 PMC3769628__F2 Four current models of PARP inhibitor-induced cancer cell killing ATM BRCA2 RAD51 PTEN BRCA1 PMC9569475__F5 Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects STAT1 STAT3 PMC3621569__F3 Inversin functions as a switch between the canonical Wnt and non-canonical Wnt/PCP pathways APC GSK3B LRP5 LRP6 ARHA PMC7795665__F3 PPARG involved in trophoblast differentiation GCM1 PMC5086000__F1 Inflammasome Activation Mechanisms during Bacterial Sexually Transmitted Infections (STIs) NLRP3 NOD1 MYD88 AIM2 IL1B PMC9261390__F1 Implications of Sphingolipids on Aging and Age-Related Diseases CERS3 LASS1 DES CERS5 SPHK1 SPHK2 CERS2 CERS6 PMC8080836__F3 GD T cells IL18 CD27 SOX13 ZAP70 BTLA CTLA4 IL1B IFNG STAT3 PMC12154794__F3 Retinoids and fibrosis SMAD2 EPHA2 TGFB1 PMC9253924__F45 Inhibition of anti-inflammatory pathway through suppressors of cytokine signalling (Socs2/Socs3) in the initiation of hepatocellular carcinoma SOCS2 SOCS3 CYP1A1 MYD88 KRT18 CYP1A2 CYP2E1 PMC7521313__F7 Mechanism of danshen on heart failure is mediated by MyD88‐dependent TLR4‐TRAF6‐NF‐KB inflammation pathway’ TLR4 RELA TRAF6 PMC10242999__F2 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer SRC TF CDC42 PMC3849481__F6 Schematic diagram showing CSFV triggers RIG-I and MDA5 dependent signaling pathway to IRF-3 and NFKB activation to promote the production of antiviral and inflammatory cytokines in porcine alveolar macrophages TBK1 IRF3 CSA2 IL1B PMC4278548__F1 Central metabolic routes and the aromatic compounds biosynthesis showing key metabolites and the genes involved in their transformation PPY AAMP CIT MAL PMC10242999__F3 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer EGF F3 PTEN RAC1 TNF MTOR TF PMC5466514__F1 Cancer cells take advantage and manipulate the ROS-Ca2+ interplay in two ways: 1) by inhibiting large ROS-Ca2+ surges that mediate apoptosis (red pathway) TRPC1 TRPC6 MCU TRPM2 ORAI3 ORAI1 STIM1 TRPV1 PMC5510801__F1 Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model APC SFRP1 DKK1 PMC7521313__F3 Danshen is shown to regulate the TLR signalling pathway PIK3CD CD14 CTSK TLR9 MAPK10 CXCL10 IL6 RAC1 TLR8 MAPK13 TLR4 FRK opn LBP CD80 CSA2 IL4 FADD TIRAP PMC4085163__F6 Schematic models of signalling pathways used by SDF-1/CXCR4 and GLP-1/GLP-1R in the activation of beta catenin/TCF7L2-mediated transcriptional expression of genes involved in beta cell survival and proliferation a SDF-1 activation of WNT signalling APC CXCR4 TCF7L2 PMC7467536__F2 PRC2-mediated feed-forward control of transcription factors and signaling pathway components can serve as a “dimmer switch” of gene expression changes PROZ COMP TF PMC9600545__F4 Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance STAT1 IL4 IFNGR1 IFNG PMC12235416__F1 (Figure created using BioRender MAML1 ADAM10 ADAM17 PMC5352108__F1 Long non-coding RNAs in anti-cancer drug resistance PTEN PMC7000272__F1 RELA interactome PLK1 FOXO3A SQSTM1 VEGFA RELB CXCL8 HIF1A NOTCH3 NOD2 SOX9 ELF3 NFKB2 TWIST1 NFKB1 CYLD RELA BCL2 CASP8 PMC8834144__F8 Comparative Transcriptomic Profiles of Differentiated Adipocytes Provide Insights into Adipogenesis Mechanisms of Subcutaneous and Intramuscular Fat Tissues in Pigs PLK2 DGKD FOS THBS3 CA13 GALNT6 PFKL MTHFD2 CYCS PMC7072933__F1 Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma TSC2 TSC1 MTOR RHEB PMC9485270__F5 Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance BRAF NEDD9 NRAS MYC PTEN CDKN2A TERT PMC11084446__F8 Brief diagram of the proposed therapeutic effect of the LiESWT in improving detrusor hyperactivity via TRPV channels and the cellular signaling pathway involved in regulating intracellular Ca2+ oscillation in a rat model of OHD-induced DHIC TRPV4 ARHA TRPV1 PMC5055575__F9 The signalling pathways mediating PTH and BMP-2 induced regulation of Phospho1, Smpd3 and Alpl in osteoblast cells ALPL PTH1R BMPR1A BMP2 PHOSPHO1 PTH ALPI PMC8631470__F1 Cross-Talk Between Tumor Cells Undergoing Epithelial to Mesenchymal Transition and Natural Killer Cells in Tumor Microenvironment in Colorectal Cancer HMGB1 CADM1 MICB MICA TIGIT CRTAM ADAM17 PCNA BAX PMC5833552__F1 Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation TLR4 TLR9 BCR CD40 CD80 IL1B PMC7467536__F1 PRC2 core and accessory proteins and downstream effects ME1 ME2 EPOP ME3 AEBP2 PMC3218884__F4 Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA RBBP4 KHSRP HNRNPL PROX2 HEL-S-99n DEK HDAC2 HEL113 RB1 LMNA FUS PMC11772333__F5 Biosynthetic pathway of three representative pyrroles UROD UROS PIGC POR CPO PMC4512304__F2 Ramification of IFN signaling pathways leading to immunostimulatory and immunosuppressive regulation of macrophage polarization IRF9 CXCL9 TYK2 IFNAR2 JAK1 IFNAR1 IRF-1 MX1 PMC7374916__F10 Schematic illustration of the proposed mechanism for H2R/H3R to alleviate microglia-induced neuroinflammation TLR4 IL1B FOXO1 PMC5527800__F3 Ingenuity pathway analysis EIF2S1 HGF MAPK3 MMP11 NNMT MYC ADAM17 SELL DAG1 MMP3 PLAT A4GALT MMP2 FCER2 MAPK1 JUNB ACAN GAL LOXL2 PLAUR FOS IGF2 NR0B2 LCN2 CD44 HRAS TG IRS1 ST14 THY1 CTSG LEP EDNRA MMP14 TIMP1 CD40 JUND KLF2 OSM TGFB1 MME SP3 INHBA TGFBI PMC6534900__F3 Summary of the regulation network of Ids in heart development is shown SMAD4 GATA4 ISL1 FOXA2 MESP1 WNT3A KDR BMPR1A SMARCD3 ACVR1B TBX5 SMAD1 DKFZp781O1323 PMC11647257__SF2 Various signaling molecules, such as glucocorticoids, androgens, progesterone, BMP4 (which activates SMAD), and IL-6 (which activates the downstream signaling molecule STAT3), regulate the transcriptional activity of S100P in cancer cells CACYBP S100P BMP4 STAT3 PMC5062963__F7 Comparative model of transcriptional activation of ERA by cognate ligand versus cAMP signaling in the absence of estrogen CARM1 GRIP1 REST HDAC1 PMC4254647__F3 FA/BRCA DNA damage response pathway PALB2 BRCA2 BRIP1 UBE2T RAD51C USP1 PMC6994583__F1 Pathways of H2S production VIT PMC8065809__F10 Postulated model for the mechanism underlying IGF-Trap resistance in MDA-MB-231 FGFR1 FRS2 GRB2 PMC9458025__F3 Functional Annotation of Lactiplantibacillus plantarum 13-3 as a Potential Starter Probiotic Involved in the Food Safety of Fermented Products XK ALB SHE ENG WAS BOK PMC2872188__F2 Generalized depiction of the energy cost of neurovascular coupling and its impact on astrocytic glucose utilization (CMRglc) PLAA PMC3305403__F4 The Nucleoside Diphosphate Kinase Gene Nme3 Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance FGD2 RHO NME3 PMC6631168__F1 The Role of Wnt and R-spondin in the Stomach During Health and Disease ZNRF3 SOX2 RNF43 APC GSK3B LRP5 LRP6 GPR49 LGR6 SOX9 PMC9205222__F2 Molecular Approaches Reduce Saturates and Eliminate trans Fats in Food Oils LPA HEL-S-5 PMC8529064__F5 Microbiota in Infant Health: From Early Life to Adulthood HBD TIFA TRAF6 PMC2750148__F2 NFKB signal transduction UBC TRAF6 MYD88 PMC4959106__F1 De novo SL biosynthesis and S1P metabolism APOM S1PR1 DES SPHK1 SPNS2 SPHK2 PMC5466881__F1 Strategies for Increasing Pancreatic Tumor Immunogenicity CXCL13 GEM CD40 CCL2 PMC11177172__F5 Regulatory associations between protein-protein networks, based on the IPA Knowledge Base HMGB1 AHNAK EIF1AX RPS15 RPS9 TRIM25 RPS10 SRP9 FABP5 PCBD1 RPS12 CP TARDBP RPS15A PMC4959106__F3 Nogo-B regulates de novo SL biosynthesis through the inhibition of SPT activity to control vascular tone and BP S1PR2 NONO S1PR1 ARHA SPNS2 PMC8533259__F3 Coordination of RNA Processing Regulation by Signal Transduction Pathways MDM2 ATR PMC7346062__F5 KEGG pathways related to resveratrol-targeted genes TP63 MDM2 AKT3 PMC4401777__F7 Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors NFE2 EGR1 HEL-S-76p HDAC2 SP1 GRN tal-1 NFYA GATA2 PMC8154354__F2 Insights into Ammonia Adaptation and Methanogenic Precursor Oxidation by Genome-Centric Analysis MTR POR AMT PMC2246131__F7 Schematic diagram showing the possible effects of the reelin pathway in protection from CM RELN VLDLR GSK3B SRC DAB1 PMC5988607__F1 Signaling network of MST1 and MST2 kinase FOXO3A LATS1 MOB1A MOBKL1A LATS2 PMC5727869__F10 The function mechanism of HER2-HER3 co-expression MTOR STAT3 PMC9033932__F3 Targeting TGFB signal transduction for fibrosis and cancer therapy SPSB1 SMAD4 PMC4214731__F8 Network-Based Classification Model for Deriving Novel Drug-Disease Associations and Assessing Their Molecular Actions PLCG1 A2M AGTR1 MTG1 PTPN11 GRB2 CREB1 IL2 SOS1 PPARG FOXO1 STAT3 PMC4909545__F1 Nutrient-sensing mTORC1: integration of metabolic and autophagic signals TSC2 TTI1 DAPK2 TSC1 TFEB AMBRA1 ATG101 DEPTOR RHEB PMC11803499__F2 B cell signaling is integrated downstream of activating receptors to regulated B cell‐specific cellular functions and B cell fate decisions TLR9 RELB TRAF3 TRAF6 EIF4E MYD88 MTOR CD79B DEPTOR CD79A RHEB TSC2 BTK RICTOR TSC1 TLR7 BCR RELA LYN CD40 SYK TRAF2 CD19 PMC5024535__F6 Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression CDA DPYD DPYS DTYMK TYMS NTS DCTPP1 TYMP PMC10707303__F5 Fibrotic factors in the development of DKD STAT1 MMP2 WT1 PMC11803499__F4 Inhibitory receptors modulate the PI3K/AKT/mTOR pathway to influence B cell fate decisions TSC2 RICTOR TSC1 BCR CD22 CD40 PTEN DEPTOR RHEB PMC4640679__F5 Non-biased molecular screening identifies novel molecular regulators of fibrogenic and proliferative signaling in myxomatous mitral valve disease CD14 FCGR1A HGF CX3CR1 RUNX2 FOS CX3CL1 MYC CD83 WNT9A MMP16 TLR3 SIK1 CD69 TOB2 BMP4 FGF9 IL7 TLR7 MMP2 CD93 JUN TCF4 FZD8 PMC4633932__F2 Nutrient, growth factor, and energy sensing impinge on the mTOR pathway RICTOR MTOR RHEB PMC5512170__F3 Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks VPS35 FKBP15 SNX27 VPS29 PMC2975092__F6 Biological interaction between glucose and genes up- (light grey) or down-regulated (white) in primary hepatic stellate cells after overexpression of Smad7 AKAP12 HGF EPHX1 HEL-S-101 VEGFA NR2F1 HEL-S-14 EIF4EBP1 CYP2E1 LPL ENO2 PFKP HK2 PMC6441107__F7 Proposed diagram for miRs-449 regulation in doxorubicin sensitivity and resistance cells CDK2 CDK4 RB1 CDK6 CCNE2 PMC7334005__F6 Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space ALAS1 CRY1 NAMPT HDAC3 NCOR1 OGT HDAC2 SIRT1 PER2 PMC11663674__F1 Isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities ME1 PDC TES PPY CUTC PMC6796923__F4 LSECtin-BTN3A3 axis promotes breast cancer stemness in vitro BTN3A3 SOX2 PMC4809656__F8 Molecular mechanisms by corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway MAML1 NOTCH1 MTOR HES1 PMC8901598__F2 Metabolic and Epigenetic Regulation by Estrogen in Adipocytes TDG UCP1 EBP ERG KDM4B EZH2 PPARG ADRB3 TET2 PMC2637898__F2 EGFR signaling pathways TSC2 GRB2 PTEN MTOR PMC2637898__F3 EGFR signal transduction pathways EGF EGFR HBEGF TGFA PMC2637898__F4 VEGF signaling pathways VEGFC NRP1 NRP2 PMC6829200__F1 Components and regulatory factors in the complement alternative pathway (CAP) HEL-S-62p CS CFH CFI PMC4663505__F7 Drug target prioritization by perturbed gene expression and network information PTGS2 EGFR JAG2 ADFP MYC PTGES CREB1 SPRY1 PTEN TNF WT1 TFF2 WNT4 NFKB1 KLF4 LYPD3 RHOF PPARG JUN ADM RHOB BAX PMC5298971__F1 Vitamin D synthesis pathway CYP27A1 VIT NR1i1 CYP2R1 CYP24A1 CYP27B1 PMC3772119__F1 Drosophila JAK-STAT pathway in blood cell formation and immunity GAA LAT BCL6 PMC2763507__F1 Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses MARCKS BAD JUND BDNF PMC4344844__F2 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development GRB2 PTEN MTOR PMC6759464__F1 Abbreviated summary of monocyte activation pathways IL16 TLR4 CRP LBP CCL18 PMC8996539__F4 Neutrophil degranulation and myocardial infarction MMP3 MMP7 MMP2 PLG MMP9 CD36 PMC7564943__F6 AhR-induced cyclooxygenase (COX) 2/PGE2/EP4 has differential effects in anti-viral cells vs COX2 PDC AHR PMC11079401__F2 MiRNAs in EMT regulation via TGFB signaling pathway in pancreatic tumor cells SMAD2 NRP1 SMURF2 SMAD4 ARHA RAF1 DUSP2 PMC11079401__F3 MiRNAs in EMT regulation via PI3K/AKT signaling pathway in pancreatic tumor cells S100P KDM5B ANXA3 MTOR PMC7564943__F3 AhR activation contributes to alterations in mitochondrial metabolism as does suppressed pineal melatonin ASMT COX2 PDC AHR AANAT PMC10670414__F8 Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells STEAP3 EGFR STAT5B BAX PMC11079401__F4 MiRNAs in EMT regulation via WNT and JAK/STAT signaling pathways in pancreatic tumor cells SOCS3 APC LRP5 LRP6 ST7L SOCS5 PMC8841354__F5 Interleukins and Ischemic Stroke IL18 IL33 IL1B PMC6066316__F8 Differentiation of monocytes promotes resistance to ripoptosome signaling RIPK1 TLR4 RIPK3 IFNAR1 MLKL PMC8001593__F3 Host-catalyzed HIV-1 assembly pathway was developed into a screen for small molecule inhibitors XRN1 PMC5683051__F1 Interconnection between endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathways and mitochondria-NLRP3 inflammasome in allergic diseases NLRP3 ATP6 ATF4 EIF2A IL1B PMC8431527__F1 Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature ING4 RUNX3 VHL ARG1 LIMD1 STAT3 PMC4344844__F3 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development APC LRP5 LRP6 PMC11900433__F9 Phosphoinositide 3-kinase (PI3K)/Akt pathway PTEN MTOR PMC11904867__F2 Nur77 in glucose metabolism ENO3 HEL-S-30 FBP1 PIR ENO1 MTOR PGAM2 PMC9515456__F4 Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories EDC4 AGO2 EIF2A XBP1 DCP1A PMC11900433__F8 MAPK/AP-1 signaling pathway MAPKAPK2 MAPKAPK5 MAPKAPK3 RAC1 PMC7940537__F1 MTORC1 signaling and glycolysis pathways EIF4E MTOR DEPTOR PMC11900433__F5 NRF2–ARE pathway KEAP1 RBX1 PMC5009750__F1 NFKB pathway genes with correlation to HOXA1 expression in breast cancer PLCG1 NGF TRADD TRAF3 TRAF6 LY96 BCR ATM BASH TNFSF14 CD40LG CD14 PTGS2 LTB CXCL2 TNF TRIM25 CNTF LTA PRKCB TNFSF11 NFKB2 NFKB1 LCK LBP LYN ZAP70 BCL2 CD40 SYK CXCL12 TRAF2 LTBR LAT TIRAP PMC6531411__F1 Diversity of the effects of DJ-1 in cell TH DDC KEAP1 CMA1 PTEN TOPORS BAX PMC5384354__F9 Proliferation by crosstalk of miR-204 and miR-17/92 in smooth muscle cells SRC PAH STAT3 PMC7481292__F5 Summary of effects of TCDD on OCM gene expression and metabolites HEL-S-61p HEL-S-182mP PMC8430083__F5 Comprehensive network analysis of different subtypes of molecular disorders in lung cancer BTK TNC SOCS3 MPO RECK AGER CCL2 ITGAV COMP COL1A1 SKP2 PMC4593320__F2 Role of Bmi-1 in Ink4a/Arf Pathway PRC1 MDM2 CDK4 PMC8066025__F2 Indirect antiviral activities of PARPs through immunomodulation DTX3L PARP14 TANK PARP12 PARP11 PARP10 IRF3 IFNG PMC10310985__F4 DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer APC EGFR GRB2 PTEN MTOR TRAF2 STAT3 PMC6503977__F7 Proposed Shh-Foxd1-Cdkn1c signaling model PTCH1 SHH CCND1 SMO CDK4 CDKN1C FOXD1 PMC6892507__F5 Gene expression is associated with virulence in murine macrophages infected with Leptospira spp ATM PMC2871799__F6 Human endometrial receptivity HEL-S-62p BMP6 PROS1 PLG MASP1 TGFBR1 PROC JAM3 FST DCN HEL-S-78p F2 BDKRB2 SERPINF2 PMC11937194__F5 Related mechanisms of TRPC1, TRPM7, CLCA2, CLCA4, and TTYH3 in the process of EMT TRPC1 RAF1 CDH2 TTYH3 TRPM7 CLCA4 PMC11937194__F6 Related mechanisms of TRPV1, TRPM8, Orai1and KCa3 TNF ORAI1 TRPV1 CD69 TRPM8 PMC11937194__F7 Related mechanisms of TRPC3, TRPV1, L-VGCC, A2D1 and TTYH3 in regulating tumor stemness MMP2 CCND1 TRPC3 HRAS TTYH3 TRPV1 PMC8170311__F1 Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia SLC7A5 NPM1 EZH2 FLT3 CD36 PMC11937194__F4 Related mechanisms of TRPV3, TRPV4, and Orai1 in tumor angiogenesis TRPV4 TRPV3 ORAI1 PMC9457814__F2 Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches MTOR TF PMC8172474__F1 Therapeutic Escape in GAq-Mutant Uveal Melanoma: It’s a FAK RHO LAG3 TRIO BAP1 PMC7585948__F10 Targeting feed-forward signaling of TGFB/NOX4/DHFR/eNOS uncoupling/TGFB axis with anti-TGFB and folic acid attenuates formation of aortic aneurysms TGFBR1 DHFR TGFBR2 NOX4 PMC3882126__F1 Autism genes keep turning up chromatin JMJD1C ARID1B SMC1A GABRB3 NLGN3 CHD8 SHANK3 NRXN1 MTOR SMARCC2 SMARCC1 PMC5359687__F1 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field ME1 PSAT1 HEL107 HEL-S-133P GLUD1 FASN GLS PMC8524664__F10 Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3B signaling pathway GSK3B BAX PMC5359687__F6 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field CXCL12 MTOR FOXP3 PMC10380285__F1 Influence of Single Nucleotide Polymorphisms on Vitamin D Receptor Protein Levels and Function in Chronic Liver Disease NR1i1 SRC SP1 SP3 PMC8727779__F3 Strategies to overcome drug resistance using SHP2 inhibitors EGF CSK GRB2 SRC PMC3939323__F3 A, JAK-STAT signaling pathway in interaction network PIM1 EPO IL6 CBL PMC9377404__F8 Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis HEL-S-302 AKR1B10 DAO UGDH SORD POR GUSB AOX1 HEL-S-165mP IL18 PSAT1 XYLB DCXR HEL30 PMC8196896__F3 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections TRAF1 TNF TRAF2 PMC8196896__F2 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections RIPK1 TRADD SMURF2 RIPK3 TNF TRAF2 FADD PMC8923098__F1 Reversing epigenetic repression of transposable elements for improving tumor immunogenicity CGAS SETDB1 TES MAVS PMC5189614__F1 Cellular control of hyperglycemia EGF IGF1R EGFR GRB2 MTOR PMC4701041__F7 Proposed model for a critical role of ERA in E2-induced cholesterol gallstones ABCB4 ABCG5 LDLR ABCB11 PMC3434475__F1 The canonical translation pathway in eukaryotes with the ribosomal recycling and initiation phases shown in detail ELF2 ELF5 ELF3 ELF1 SUI1 ABCE1 EIF4B EIF5 PMC10993426__F2 Metabolites, metabolic pathways and related metabolic genes that take part in necrosis and necroptosis ATF4 STRAP GLTP ZBP1 MLKL PMC2930269__F2 CSCs drug resistance methodology CD47 ABCG2 ABCB1 PMC10993426__F3 Metabolites, metabolic pathways and related metabolic genes that play the roles in ferroptosis GPX4 SLC7A11 HEL-75 TF BAP1 PMC7520711__F1 Major regulators and effectors of the phosphatidylinositol 3-kinase (PI3K) pathway in lymphocytes PIK3IP1 PI3 BCR PTEN INPP4B MTOR CD19 PMC10993426__F1 Metabolites, metabolic pathways and related metabolic genes that play the roles in apoptosis TIGAR NAMPT SCD TRADD APAF1 ETV4 ACLY MTOR FADD BAX PMC10993426__F7 Metabolites, metabolic pathways and related metabolic genes that work in autophagy STK11 SIRT1 HEL-S-162eP PMC10993426__F4 Metabolites, metabolic pathways and related metabolic genes that play the roles in pyroptosis NLRP3 GPX4 IL18 LDLR HEL-S-104 GSDMD PMC11647257__SF6 CNN1 signaling pathway involved in cancer MMP2 MMP9 DKK1 HEL-S-14 MTOR PMC8236857__F2 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead MAX PTCH1 MIA MYC PMC8236857__F3 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead IL13RA2 EPHA2 HMGCR FASN PMC4509978__F2 CMV-induced embryonic mouse organ of Corti dysplasia: network architecture of dysfunctional lateral inhibition HES5 HEY2 ATOH1 JAG2 FGF8 FGFR3 NOTCH1 PROX1 PCNA PMC10875085__F2 Mechanisms for E protein-induced lung injury NLRP3 PALS1 IL6 MYD88 PMC11725633__F2 Immunoregulation of CD4+ and CD8+ T cells by fatty acids CD5L PCYT2 ACLY GATA3 FASN FOXP3 PMC5898978__F1 Prostaglandin E2 as a Regulator of Immunity to Pathogens LTA LTB PMC11725633__F1 Fatty acid metabolism in T cells FFAR3 FFAR2 FFAR1 LPA FASN CD36 PMC7775286__F1 Diagram of NK cell receptor signaling: FYN VAV1 ZAP70 SYK KIR2DL4 LAT PMC7157668__F1 Mycobacterium evades macrophage apoptosis by induction of anti-apoptotic cytokines and miRNAs expression BAD EBI3 BCL2 TYK2 FADD TRAF4 STAT3 BAX NOP53 PMC7734804__F1 Initial establishment of anti-viral state via innate immune responses to DENV infection TBK1 CGAS IRF7 TRAF3 TRAF6 IRF3 MYD88 MAVS PMC10452836__F7 Reconstructed network using StringDB of the dynamic interactome of KRASG12C (grey halo) in HEK293 cells identified in the AP-MS screen WTIP JUP RADIL PMC10875085__F1 Mechanisms for S protein-induced lung injury NLRP3 TLR4 IL6 ACE2 STAT3 PMC3703753__F2 Impact of Subarachnoid Hemorrhage on Parenchymal Arteriolar Function KY EGFR HBEGF PMC10879484__F7 Predicted activation of macrophage classical activation signaling pathway in parenteral nutrition piglets PARP14 CD14 HEL-S-30 CYBB TNF IFNG TLR4 NDUFS1 RELA GBP2 CCL20 MERTK IRF-1 PMC10879484__F8 Therapeutics identified as strongly inhibited upstream regulators in Ingenuity Pathway Analysis CREBBP STAT2 FOS IRF9 MED1 JUN NR1H4 PMC3083951__F3 A model (steps 1-4) for copper homeostasis in Schizosaccharomyces pombe (Schiz COX17 SCO1 COX11 PMC4550399__F8 Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays CUTA C6 PMC5045492__F2 Depiction of the organization of the major steroid biosynthetic pathways in the adrenal cortex SULT2A1 POR STAR CPD PMC5012644__F2 Hypoxia-inducible transcription factor (HIF) pathway in clear cell renal cancer PBRM1 ELOC VHL SETD2 BAP1 PMC2646147__F6 A model for three pathways of TLS in mammalian cells POLK POLN CPD PMC7103649__F9 Significant correlations between HSD17B4, ACAA1, and PXMP4 expressions and immunomodulator gene expressions TNLG2A HLA-E CDA TNFRSF14 TMIGD2 HHLA2 MICB LGALS9 HAVCR2 ULBP1 TNFSF13 TNFRSF9 KIR2DL1 KDR TNFRSF4 TAP2 TNFSF14 CD2 KLRK1 B2M HSD17B4 IL10 TNLG1B PXMP4 CD160 BTLA KLRC1 CTLA4 TIGIT HLA-B HLA-F TAPBP HLA-A TNFRSF25 IDO1 LTA CD27 TNLG8A CXCR4 TNFRSF18 CD180 CD40 IL2RA CXCL12 HLA-DMB TNFRSF17 TGFB1 PDCD1 PMC4718075__F2 Adipocytokines and Hepatic Fibrosis SOCS3 STAT3 APPL1 PMC6104113__F7 Simplified schematic showing the potential strategy for muscle‐derived miR‐23a/27a to attenuate muscle atrophy and renal fibrosis IGF1 SMAD2 PTEN PMC9588789__F7 Schema depicting the BET inhibitor resistance in PCa cells due to RB loss and hyperphosphorylation CDK4 CDK6 GNB1L BRD4 PMC9576946__F1 Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion PIK3IP1 MCM5 CDC2 MTOR PCNA PMC3297025__F1 IL-1 signaling leads to actin stress fiber formation IRAK1 IRAK2 TRAF6 IRAK4 RHO MYD88 PMC3297025__F2 BTB restructuring and spermiation are coordinated by IL-1A during spermatogenesis IL10 IRAK1 IRAK4 MYD88 PMC9140926__F10 Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NFKB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells COX2 CSA2 IL1B PMC9240468__F5 MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis E2F4 YAP1 YBX1 SMAD2 APC TGFBR1 MDM2 FZD7 LATS1 ST8SIA1 LATS2 PMC4012311__F11 Regulation of TRN mechanosensation PI3 PMC5429979__F2 Glutamine/glutamate utilization in proliferating cells ME1 PIG59 BCAT2 GPT HEL-S-32 SLC7A5 PDC GOT2 SLC25A13 GPT2 PSAT1 MPC1 MPC2 SLC3A2 SLC25A1 GLUD1 GLS PMC5429979__F3 Serine/glycine metabolism in proliferating cells PSAT1 SHMT1 DHFR PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH PMC8264290__F1 Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm HEL-S-62p SOCS3 IL13 FOS TRAF3 TNF NOD2 TRAF2 JUN FADD MLKL SELE ITCH PMC4633493__F1 Mechanisms through which microRNAs (miRNAs) implicated in the TGFB signaling pathway in the lung epithelial cells and fibroblasts SMAD2 SMURF2 SMAD4 STAT3 PMC6581552__F2 Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets FGF21 CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 NR1C1 PMC3578987__F2 MITOCHONDRIAL GLUTATHIONE: FEATURES, REGULATION AND ROLE IN DISEASE UROS TNF PMC6886551__F4 Protein–protein interaction network of the differentially expressed proteins between IH-exposed HUVECs treated with or without estradiol (E2) WDR26 MTOR DAG1 USP34 ATM GPT2 TFB2M PTPN11 RBM28 HDAC2 MEAF6 NDUFAF4 BRAT1 EHMT1 NOC4L PRPSAP1 LACTB NUDT19 SAMM50 CSTF1 RPRD1B SH3GL1 TXNL4A MRPL47 RPRD2 TRIAP1 RPS6KA1 ARL1 BRD3 ASNS COQ9 AK1 PMC6002380__F4 NOD-like receptor signaling pathway CARD9 TRIP6 CCL2 MAP3K7IP1 NOD2 TAB3 PMC7582305__F6 Downstream signaling cascade activated by ATR and ATM via CHK1/2 dependent phosphorylation events MDM2 BAX PMC10686798__F1 Wnt/Bcatenin signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 GPR49 PMC10995981__F2 CircRNAs play a pivotal role in the advancement of esophageal cancer by modulating the Wnt pathway through diverse mechanisms FZD3 SRXN1 SOX4 ITCH PMC10995981__F3 circRNAs play a pivotal role in the initiation and progression of liver cancer by regulating the Wnt pathway through diverse mechanisms ZIC1 E2F6 DKK3 APC RTKN2 E2F3 HEL-S-68p PMC6481643__F10 Novel IL-1Beta-ILC3-IL-2 circuit is essential for the maintenance of Tregs and immunologic homeostasis uniquely within the small intestine MYD88 IL1B NOD2 FOXP3 PMC3493339__F4 STRING Network EREG PLCG1 EGFR CBL NCK1 STAT1 UBC ERBB2 PTPN1 PTPN11 GRB2 SRC PTPN6 TGFA SHC1 STAT3 PMC11798966__F1 Proposed mechanisms of NLRP3 inflammasome activation and regulation in HBV infection NLRP3 TLR4 GSDMD PMC3493339__F1 ERBB Pathway EGF BAD BTC SHE MTOR JUN CBL PMC7349634__F1 Pathways of synthesis of oxylipins from Eicosapentaenoic acid (EPA) and ARA PUFAs TES GLA PMC6168629__F3 Regulatory mechanisms that control the switch from PKM1 to PKM2 MYC NEK2 SFRS3 MTOR RBM4 PMC7593653__F5 Diabetes-induced cardiac UPS dysfunction MAF KEAP1 IRS1 NR1C1 FOXO1 RFWD2 GATA4 PMC7293394__F1 Antibody-mediated complement activation in pathology and protection CS CD46 BCR CR2 CR1 CP PMC4016892__F6 Schematic model illustrating the signaling pathway by which ANG suppresses the inflammatory response involving TBK1-mediated NFKB nuclear translocation in HCFs inflamed by TNFA IL10 IL18 IL4 PMC3246422__F10 PP-associated modulation of inflammatory chemokine production and repair-related processes in keratinocytes through EGFR system EGFR RHO TGFA IFNG STAT3 PMC4088925__F3 Summary of expression patterns of complement components in the placenta HEL-S-62p CD59 C9 FH CRP CR1 CP PMC7601592__F1 Most important approaches to melanoma treatment KIT BRAF PMC8298002__F5 Physiological, Genomic and Transcriptomic Analyses Reveal the Adaptation Mechanisms of Acidiella bohemica to Extreme Acid Mine Drainage Environments FTH1 PMC10375050__F3 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease TIFA TRAF6 ALPK1 PMC6941427__F4 Differentially expressed genes (DEGs) involved in flavonoid metabolic pathway and lignin metabolic pathway GC CAD GCG PMC8400831__F4 CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature HP ACE2 TMPRSS2 PMC6941427__F6 Differentially expressed genes (DEGs) involved in terpenoid metabolic pathway MDC1 MVK IPP PMC3444914__F1 The DNA base excision repair (BER) pathway POLE PCNA PMC6941427__F9 The regulatory network of key long non-coding RNAs (lncRNAs), genes, and metabolites involved in flavonoid metabolic pathway, terpenoid metabolic pathway, and jasmonic acid/methyl jasmonate (JA/MeJA) biosynthesis and signal transduction pathway MVK CAD GCG PMC10375050__F2 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease NOD1 TRAF6 IRF3 NOD2 PMC6953035__F10 Proposed model depicting the impact of PC1/3 knockdown on the activation of TLR4 TLR4 IRF3 MYD88 STAT3 PMC8883233__F2 MCL1-mediated regulation of apoptosis BCL2 MCL1 BAX PMC5071578__F5 Role of TSN in carcinogenesis CXCL16 TGFB1 TSN HEL-S-43 PMC5038578__F1 Molecular pathways associated with inflammatory bowel disease IL10 ATG16L1 LRRK2 ITLN1 CCR6 IRGM PTGER4 SLC22A5 TSLP IL23R XBP1 NOD2 DLG5 IL12B NLRP3 CARD9 TLR4 ARPC2 DMBT1 TNFAIP3 IL18RAP STAT3 PMC4278335__F4 In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma EGF EGFR EHD2 EHD3 ARHA PTEN VPS28 MTOR SMURF1 VPS36 RNF41 NEDD4 CBL ERBB4 VPS25 MDM2 LDLR CLTC ARF6 CDC42 ITCH PMC9494158__F4 Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms TLR4 MYD88 MAP3K7IP1 STAT3 PMC9164031__F6 Inhibition of eNOS Partially Blunts the Beneficial Effects of Nebivolol on Angiotensin II-Induced Signaling in H9c2 Cardiomyoblasts RAC1 RPS6 MTOR PMC6699409__F2 MTORC1 and MEK-ERK signaling pathways regulate eIF4F activity and assembly EIF4E EIF4B CYFIP1 PMC5513767__F1 Complementopathies HEL-S-62p C4B_2 C1S PMC4614807__F2 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus IRX3 CS RBM10 CFB FOXF2 MAFF MYH10 ATAD2 PRPF19 SOX9 SOX4 LIMS1 AHR PTPRG RASSF1 HEL-S-77 IRF-1 PBR SUMO1 PMC5123561__F3 Heterotrimeric G Proteins: Breaking the rules of engagement, space and time PLCG1 SMAD2 MMP9 EGFR CDK5 MTOR FOXO1 INSR TLR4 MMP2 SRC BCL2 STAT3 PMC4614807__F8 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus STAT1 IFIT3 IFIT2 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 IFIT1 PMC6953081__F2 Regulation of eIF4F complex formation by PI3K/Akt/mTOR, MAPK/MNK, and AMPK pathways and drugs targeting these pathways EIF4E EIF4B PMC8014301__F1 The SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection INA S1PR2 S1PR1 S1PR3 S1PR5 RHO S1PR4 PMC8829062__F1 Deciphering the Roles of Metformin in Alzheimer’s Disease: A Snapshot BACE1 APP MTOR PMC12063284__F3 SMKIs-induced cardiotoxicity SLC7A11 EGFR SRC ATF3 STAT3 PMC8640358__F5 Network Pharmacology and Molecular Docking–Based Investigation: Prunus mume Against Colorectal Cancer via Silencing RelA Expression EGF PPP3CA MAPK8 COL3A1 BIRC5 EGFR MYC BCL2L1 PTGER3 HIF1A TOP2A CYP1A2 CHEK2 MMP3 PRKCA MMP2 CCNB1 CASP9 CCND1 CYP1A1 CDC2 CASP8 BAX IL1A ADRB1 FOS PTGS2 ERBB3 MMP9 CXCL10 VEGFA ADRB2 CXCL2 RXRA HEL-S-22 IKBKB CASP3 GSTM2 NFKBIA PRKCB CDKN1A CYP3A4 RELA BCL2 NCF1 PMC11867957__F1 Classic Wnt/Beta-catenin pathway cascade diagram APC LRP5 LRP6 PMC8504100__F2 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives TH CXCL1 CCR2 YAP1 CXCL5 DPP4 CXCL2 CCL5 TSLP FOXP3 CLCF1 CXCR4 FAP MSC CCL17 MICA CXCL6 CCL22 CHI3L1 CD68 STAT3 PMC8504100__F3 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives CCR2 FAP CXCR4 IL6 CTLA4 CCL2 STAT3 PMC6497965__F6 Proposed signaling cascade for phosphorylated PCNA-promoted EMT ATM GSK3B PCNA PMC7749093__F1 Cardiovascular molecular imaging CCR2 FAP CXCR4 SSTR2 PBR PMC6843074__F4 IL-22 signaling pathway for expression of acute phase response proteins MMP3 CXCL5 S100A8 IL22 CDK4 CCL2 S100A9 S100A7 PMC9307950__F4 Sex-biased adaptive immune regulation in cancer development and therapy TLR7 TLR4 TLR9 SHBG NR1B3 HSD17B1 PMC11866596__F1 TREM1 signaling pathway CARD9 TREM1 ZAP70 GRB2 TRAF6 SYK MYD88 STAT3 PMC2106361__F1 Current model of the Fanconi anemia pathway FANCD2 BLM RAD18 BRCA1 FAAP24 FANCM FANCL FANCA ATR FANCB FANCE PCNA FANCG FANCF PMC6590191__F3 Interaction network formed by the encoded proteins of genes showing P values of potential relevance in our study (P < 1 × 10−4), according to the presence/absence of carotid plaques AIG1 HEL-177 SH3YL1 FAM135B ADAMTS3 ADAM2 AGBL1 CATSPERD OVOL2 TEAD3 PRKCA EPHB1 NOD1 GPR132 hEMMPRIN ECE1 LLGL2 PLA2G6 SNX5 Nbla00697 CCDC148 CCDC124 TULP1 KIF17 SYNPR ARL5B BAIAP2L2 GPR158 SPOCK1 TMEM14B TRAM2 TECTA TMEM132D KIFC3 DSCAM RPS6KA2 COL25A1 PRICKLE2 NSUN6 PMC8260388__F3 Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapy TSC1 MTOR ACE2 SOCS1 PMC5339794__F3 Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis ABCC3 GGH SLC16A7 CXCL10 SLC22A11 AMPD1 HLA-DQB1 FPGS HLA-DRB1 SLC46A1 PTPN22 RFC1 TLR4 ABCC1 MTRR DHFR ADA CXCL9 TYMS CCND1 HEL-S-70p ABCG2 ABCC2 TGFB1 PMC3837590__F3 Macrophage infiltration in adipose tissues, oxidative stress and IR CCR2 LPL IL1B PMC3337163__F1 Breaking up is hard to do RALA CDC2 RALBP1 AURKA PMC2774487__F2 Pathway showing genes involved in Parkinson's disease (Courtesy: KEGG pathway) TH SNCA CASP9 HTRA2 PMC6745219__F2 Tumor Necrosis Factor Receptor 1 (TNFR-1) Signalling Pathway TRADD TRAF2 FADD BAX PMC8003366__F1 View at a glance of the landscape of the metabolic interactions between genes and pathways discussed in the manuscript HEL-S-26 TET2 BAX PMC7117101__F2 Mechanisms by which SND1 promotes oncogenesis CDK2 E2F2 TGFBR2 CCND1 SND1 PTEN SPRY2 ELL PMC4096962__F6 Combinatorial cytokine regulation of iNOS expression in IMF STAT1 IL1B IFNG PMC3515677__F1 Summary of the mechanisms of DC-mediated HIV-1 transmission to CD4+ T cells CCR5 CXCR4 PMC2874080__F2 Pathway of de novo synthesis of saturated and monounsaturated fatty acids and regulation of lipogenic genes by transcription factors (LXR, SREBP-1c and ChREBP) SCD ELOVL6 PMC9054782__F6 Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet TNF IRS1 PMC3138675__F2 Molecular mechanisms in hereditary cancer APC MDM2 PTEN MTOR PMC5682923__F1 Complex Roles of mTOR in Adipocytes and Beyond FLCN TFEB SLC38A9 PTEN GRB10 RHEB PMC5772977__F1 The transforming growth factorB1/Smad signaling pathway SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC9137176__F7 Granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin YAP1 AREG GC EGFR LHCGR PMC12072397__F3 The osteoblastogenesis signaling pathway and its lncRNA-induced regulation BAMBI GPC4 NUMB RUNX2 ROCK1 SOST MYC SMAD4 RYK DKK1 DKK2 SOX17 ROR1 PRKCA MMP7 NOG RSPO1 SIAH1 SFRP1 ROR2 TUG1 JUN ROCK2 ZNRF3 INVS RNF43 CBY1 FOSL1 APC NOTUM LRP5 CER1 LRP6 SKP1 ARHA DLX5 RAC1 ID1 NLK CACYBP WNT3 EP300 PSEN1 NBL1 hCG_2014051 FRAT1 CTNND2 SIRT1 PMC4359241__F2 Androgen receptors beyond prostate cancer: an old marker as a new target CYP2C9 CYP3A4 CYP1A2 STAT3 PMC4359241__F3 Androgen receptors beyond prostate cancer: an old marker as a new target RICTOR MTOR PMC12072397__F2 The osteoclastogenesis signaling pathway and its lncRNA-induced regulation MAFB CTSK STAT2 NFATC1 IRF8 OSCAR TRAF6 ARHA CBL STAT1 TEAD3 BASH GAB2 GRB2 SYK TUG1 SIRT1 SOCS1 PMC4258442__F3 Nitrosothiol signaling and protein nitrosation in cell death UNK FADD BAX PMC6521150__F2 Proposed model for actinomycin D assembly (A) and 4-MHA precursor production (B) in S HEL-S-62p ASMT APP PMC8395918__F7 Physalin A, 13,14-Seco-16, 24-Cyclo-Steroid, Inhibits Stemness of Breast Cancer Cells by Regulation of Hedgehog Signaling Pathway and Yes-Associated Protein 1 (YAP1) YAP1 SMO PMC9551033__F4 AMBRA1 and its role as a target for anticancer therapy SOCS3 AMBRA1 SMAD4 PTEN STAT3 PMC7468493__F1 The signal transduction pathways associated with epithelial–mesenchymal transition (EMT) EGF SMARCA4 HGF CPEB2 LGI2 FOXK1 BMI1 CDH2 TNF PMC8706716__F1 Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls? TSC2 BAD TSC1 PTEN MTOR RHEB PMC6387402__F1 Activation of signaling pathways in respiratory epithelial cells upon viral infection STAT2 IRF9 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 JAK1 MAVS PMC7217380__F2 PPI network and module analysis of HCC CYP2C19 MT1E MT1G PMC6602956__F6 Schematic diagram of NPY(1–36) expression and secretion in activated LX-2 cells and the signalling pathway involved NPY1R ELF3 NPY EIF4E MTOR PMC1183420__F1 Simplified 13-hydroxylation pathway of GA biosynthesis in vegetative tissue of pea SLN PMC11959038__F7 Association of LRP1B with the Hedgehog signaling pathway in CRC CHEK2 PTCH2 LRP1B SUFU CDK2 PTCH1 GLI3 CCNB1 SHH CCND1 SMO CDC2 PMC4615219__F1 Aberrant activation of alveolar epithelial cells (AECs) in lung fibrosis CD151 SHH IPP PMC9709420__F6 Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation HAL APP FADD PMC4796823__F1 Identification of Potential Drug Targets in Cancer Signaling Pathways using Stochastic Logical Models MUC1 BAD FOS MYC SRC EIF4E MCL1 MTOR JUN STAT3 PMC5451598__F12 Schematic pathway illustrating the inhibitory effects of BMP4 on PDGF-induced calpain-2 activation, cell proliferation, and collagen synthesis in normal and PAH PASMCs PAH TGFB1 BMP4 PMC1440308__F6 Alternative Th network STAT1 STAT4 GATA3 PMC1440308__F7 Alternative Th network ITK ATF2 STAT4 TRAF6 GATA3 PMC2965566__F2 Transcriptional control of invariant NKT cell development FYN BCL10 ZAP70 DOK1 PMC8430321__F5 Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease PCOLCE TNF PMC7460810__F1 Biogenesis pathway of YRNAs and YsRNAs RNASEL RO60 RAN PMC5446478__F3 Biochemical and metabolic changes within the tumor ACLY MTOR GLS PMC7422677__F8 Index and biological spectrum of human DNase I hypersensitive sites TH FYN ALK LCK STAT4 IL2 ZNF331 PMC5472375__F4 Based on GeneCodis3 analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, 23 significantly enriched pathways were revealed AQP1 EGFR GRB2 INS TRAF6 SCEL SLC26A3 TRAF2 SELE PMC3965409__F6 Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway CD14 TLR4 RAC1 MYD88 TRIO PMC11638059__F3 Few molecular mechanisms by which TAM affects EC MMP9 S100A8 CCR4 VEGFA S100A9 CCL22 PMC8198065__F2 PLysRS-Ap4A Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State MSC MTOR PMC4948278__F2 Cancer stem cells supporting activities of CD44v6 CAP2 MMP14 HGF CD46 CAP1 MMP2 MMP9 HEL164 CD44 ARHA PMC4948278__F4 CXCR4, a marker of migrating cancer stem cells BAD CXCR4 CD44 TSPAN8 SRC CRK PMC7811571__F1 Graphical abstract NLRP3 TLR4 ACE2 IL1B PMC4948278__F5 EpCAM-palmitoylated claudin7 complex in pancreatic cancer stem cells EPCAM HEL-S-28 GEM CD44 SRC PTEN PMC7811571__F2 Main TLR4 signalling pathways TBK1 TLR4 TRAF3 LBP TRAF6 IRF3 MYD88 IL1B TAB3 MAL PMC9013884__F7 Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases TH NGF MMP2 MMP9 EGFR IFNGR2 GIP FAAH IFNGR1 STAT3 PMC11596539__F3 UV damage and EGCG repair of collagen network layers in photoaged skin SMAD2 EGFR PMC7538181__F1 Transcriptional regulation of memory B cell differentiation IL21R TCF3 MEF2B IRF8 CDKN1B MYC CDKN2A CCND3 ID3 CCND2 BCL6 CDKN1A BCR LYN CD40 SYK EZH2 MEF2C IRF4 TCF4 STAT3 PMC7926484__F3 Dysregulated pathways governing liver hepcidin expression in PAH BMP6 HAMP SMAD2 SMAD4 BMP7 HFE SMAD1 DKFZp781O1323 TFR2 STAT3 PMC7538181__F3 Transcriptional regulation of memory B cell differentiation TLE3 BCR CDKN1A BACH2 MYC CD40 SKI CDKN2A IRF4 FOXO1 BCL6 CBL PMC8204445__F1 Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease HAAO HEL-S-90n KYNU KMO PMC6802331__F1 Schematic diagram of the JNK signaling pathway promoting cell death in ovarian cancer CASP9 BCL2 BAX PMC6862839__F4 Toll-like receptors (TLRs) in Lamellibrachia luymesi IRAK1 IRAK4 MYD88 PMC4414745__F4 Regulation of rice Hd3a and RFT1 expression by photoperiod RFT1 EHD1 EHD3 PMC6930256__F6 The networks of the PI3K-AKT signaling pathway related genes, representing the level of regulation of PI3K-AKT signaling pathway related genes compared with the blank control group in haemocytes, at various times when the HdAKT was inhibited by dsRNA EIF4EBP2 HEL-S-28 HEL-S-1 AKT1S1 AKTIP EIF4E MTOR EIF4EBP1 PARVA RHEB MLST8 TSC2 IKBKB TNFSF6 RPS6KB1 RICTOR TSC1 EIF4B TAX1BP3 PARVB PMC6802331__F3 JNK signaling pathway mediated drug resistance ATF2 SIRT6 PARP1 PMC5371185__F1 Schematic representation of the DNA damage response (DDR) pathway WEE1 ATM ATR PMC7908992__F3 Main molecular mechanisms involved in the antioxidant activity and the beneficial effects of dietary polyphenols in metabolic, cardiovascular, and neurodegenerative diseases ULK1 TFEB PMC6704558__F2 Signaling pathways for CSF-1 and FAK MDM2 SRC CDC42 PMC8282090__F8 KEGG pathways regulated by GPA2 or ASC1 as determined by sensitivity analysis IMP3 UTP15 IMP4 PWP2 UTP18 PMC2966110__F8 Stbd1 participation in glycogen metabolism and Stbd1 structure GABARAPL1 STBD1 GAA GABARAP PMC7108389__F4 TNFR and TLRs induced TNF signaling pathway USP4 RIPK1 TRADD TRAF6 MYD88 MAP3K7IP1 OTULIN TRAF2 USP48 FADD TAB3 PMC7108389__F2 Viral genome induced IFN production pathway via RIG-I and interacting DUBs TBK1 USP4 CGAS USP15 PLP2 USP21 IRF7 TRAF3 USP20 IRF3 USP25 USP18 CYLD MAVS PMC8910759__F3 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders NLRP3 CD44 TRAF6 PMC7108389__F3 TLRs, IFNARI and IFNARII induced IFN production pathway TRADD STAT2 IRF9 TRAF6 USP25 MAP3K7IP1 USP18 STAT1 RIPK1 CYLD TYK2 JAK1 TRAF2 FADD TAB3 PMC8910759__F4 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders CD14 TLR4 IRAK1 IRAK2 IL33 TRAF6 SYK IL1R1 IRAK4 MYD88 PMC9301043__F1 Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products MTOR TG PMC7382586__F1 Regulatory mechanisms of linc-ROR in breast cancer SMAD2 ZEB2 ARF6 DUSP7 PMC9187756__F1 Four ferroptosis defense pathways GPX4 OMP SLC7A11 DHFR SLC3A2 DHODH PMC4838319__F2 De novo synthesis of CoA is a highly conserved pathway that consists of 5 enzymatic steps: pathothenic acid phosphorylation, cysteine conjugation, decarboxylation, conjugation to an adenosyl group and phosphorylation PPCS PPCDC PMC2790076__F5 Comparative Analysis of Gene Expression Patterns and Cell Phenotypes between Cervical and Peripheral Blood Mononuclear Cells IKBKG CHUK MAP2 TLR9 IRAK1 TRAF3 TRAF6 MYD88 TLR8 IL18 TLR7 TLR4 opn MAPK1 CD14 TLR5 FOS CXCL10 IRF3 RAC1 TNF TLR1 IFNAR1 MAP3K7IP1 PIK3R5 NFKBIA NFKB2 CXCL9 PIK3CA CD80 TIRAP PMC11593403__F10 Characterization of phenotypes in melanoma cell populations resistant to dabrafenib or AZ628 CCNA2 GPX4 BRAF FTH1 SLC7A11 MTCH2 CCND1 AXL PMC6365902__F1 B-cell receptor pathway, which may be dysregulated in TNBC BTK CD72 BCL10 BCR BASH LYN GRB2 SYK CD19 PMC8029610__F1 CGAS–STING pathway as a therapeutic target in inflammatory diseases TBK1 CGAS IRF3 IFNB1 PMC6365902__F2 MAPK signaling pathway, which may be dysregulated in TNBC CD14 DAO FLNA TNF ERI1 SELL NLK LEP MAX APP ECSIT JUN APMAP CR1L PMC6105390__F4 Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model ABCD3 HLA-E LPCAT3 DGAT2 SLC27A2 MGLL ALDH3A2 AQP8 CPT2 NFKBIZ CCL5 EPB41L4B SLC51A RBP7 PLA1A MTTP NCEH1 SCD CYP2C18 IFNGR1 EMP1 ABCB1 BHLHB2 BMP6 SLC25A20 CXCL10 ACTN2 CYBB SSTR2 ADTRP CYP4F12 FA2H NR1C2 ARNT2 FABP1 SLC1A1 IL1R1 SLC22A3 HEL-S-128m GNAI1 CADM1 PPARGC1A ARG2 DIO1 GZMA SLC13A1 GJB2 ABCG2 ENTPD5 AXIN2 NR1H4 CTH PLK2 SLC9A3 NR3C1 PDK4 NR1C1 DBI VLDLR HNF4A MAP2K1 ACADL CPT1A HLA-DQA1 LBP SLC23A2 SLC26A3 PPARG PYGL ACADM PMC2898064__F3 Overlay of predicted functional interactions onto a human curated GBM pathway from the TCGA data set SP2 ATM HRAS PMC6365902__F3 mTOR signaling pathway, which may be dysregulated in TNBC TH RNF152 RHO PTEN SESN2 MTOR DEPTOR RHEB PMC6956866__F3 Pue for different pathways CD163 CXCR4 CD40 ARG1 DKFZp686F0183 IFNG PMC9322024__F2 Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress TFEB KEAP1 SFN VCP MTOR SIRT1 PMC8029610__F2 CGAS–STING pathway as a therapeutic target in inflammatory diseases TBK1 CGAS ENPP1 IMPACT APC IRF3 BAX SLC19A1 PMC9187756__F4 Various roles of p53 in ferroptosis CDKN1A FACL4 SLC7A11 SLC7A1 DPP4 PTGS2 ALOX15 ALOX12 PMC8354203__F3 Downregulation of miR-142a Contributes to the Enhanced Anti-Apoptotic Ability of Murine Chronic Myelogenous Leukemia Cells TIGAR MYB IRF8 PIR CER1 CEBPA CDK6 CIAPIN1 BIRC2 RAD17 E2F2 PMAIP1 TIRAP PMC7718954__F4 cGAS‐STING signaling pathway TBK1 CGAS OMP IRF3 PMC8441965__F7 Inhibin BA is an independent prognostic factor that promotes invasion via Hippo signaling in non-small cell lung cancer WWC1 FRMD6 INHBA PMC7604619__F3 Kinase pathways deregulated in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) ABL2 EPO PDGFRA NRAS NTRK3 MTOR POR CRKL FGFR1 LYN BCL2 JAK1 FLT3 IL2RB SH2B3 PMC3310875__F6 Progesterone Receptor Activates Msx2 Expression by Downregulating TNAP/Akp2 and Activating the Bmp Pathway in EpH4 Mouse Mammary Epithelial Cells BMP2 MSX2 SMAD1 DKFZp781O1323 BMP4 PMC8930095__F2 Talin-1 interaction network in cellular mechanotransduction (Review) F2 F3 ARHA PMC7718954__F1 Necroptosis, apoptosis, and pyroptosis signaling pathways RIPK1 RIPK3 TNF IL1B MLKL GSDMD BAX PMC5139081__F8 CF airway epithelium and pathogen adaptation MYD88 CFTR PMC3499061__F2 Schematic illustrations of the two significant pathways in the genome-wide gene self-reported asbestos exposure interaction analysis CANX CD47 MHC2TA CTSS EGFR CAD FAT1 FADD TAPBP PMC8184946__F8 Graph indicates the mechanisms of how TRPM2 promote pancreatic cancer proliferation and tumorigenesis CCND1 TRPM2 MEF2C PMC8634864__F2 Evolution of memory system‐related genes SRC CA12 MAL PMC4147963__F1 Natural killer cell cytotoxicity (NKCC) CAD FADD PMC6530346__F5 Effect of chronic treatment with PDF and addition of AlaGln on individual pathways TH CS RHO NACA AMBP GAA THRA APOM HEL-S-78p F2 NF2 CRP SERPING1 FGA HRG LBR HAMP CFB PLG HEL-S-92n IL6 HEL111 HP LBP AHSG APOH CP TF PMC6391774__F4 Levels of regulation of NKG2DL expression EGF SP1 TNF MTOR HSF1 PMC4640466__F2 Noncanonical Wnt/calcium pathway NLK DAAM1 ARHA RYK ROR2 CDC42 PMC4640466__F3 Wnt inhibitors currently in clinical trials APC GSK3B LRP5 LRP6 PMC4640466__F1 Canonical Wnt signaling.Notes: (A) Wnt off APC GSK3B LRP5 LRP6 PMC2744654__F5 ProMeTra visualization of relative metabolite pools and transcript abundances during fermentation of the l-lysine producer C DLD ACR PMC3243479__F3 Fatty acid Beta-oxidation, TG synthesis, and phospholipid biosynthesis pathways MADD PSD PEMT DMD PMC6029485__F1 IGF signaling pathway TSC2 BAD TSC1 IGF1R IGF1 GRB2 ARHA EIF4E MTOR IRS1 PMC5741523__F1 Hepatitis B Virus Persistence TBK1 TLR4 IRF3 MAVS PMC6029485__F2 IGF signaling pathway in pulmonary fibrosis EGR1 IGF1 EGR2 FOS PMC6823181__F1 GPER signaling pathways in cancer cells FOS EGFR RHO BAX PMC4857136__F1 Signaling pathways frequently deregulated in MDS STAT1 TRADD STAT2 TRAF1 TRAF2 FADD TF PMC2910246__F8 Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: Apoptosis through the formation of 3-hydroxykynurenine STAT1 JAK1 PMC4408919__F3 Opposing effects of target overexpression reveal drug mechanisms DHFR FPGS DHPS PMC7011253__F1 Schematic diagram of Chinese medicines direct and indirect regulating NFKB pathway in UC treatment TLR4 MYD88 STAT3 PMC3818951__F1 Osteoclastogenesis CTSK TRAF6 RB1 PMC8138161__F4 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway DKFZp686F0183 CCND2 BAX PMC8872619__F3 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells FOXM1 EGFR CDC2 PMC12024444__F3 The Hippo signaling pathway in osteoclasts RUNX2 NFATC1 TRAF6 AJUBA LATS1 RASSF2 LATS2 PMC8138161__F5 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway BCL2 MTOR DKFZp686F0183 BAX PMC8872619__F4 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells HIPK2 ATM MDM2 PTEN ATR RHEB HEL-S-69p PMC8138161__F2 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway CAD FADD PMC10311114__F2 Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges ADIPOR1 ADIPOR2 PMC12024444__F1 Hippo signaling pathway regulates cell homeostasis under many factors PAK1 RUNX2 LATS1 RHO RAC1 LATS2 PMC8872619__F2 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells CCNA2 FOXM1 E2F2 EGFR CCNB1 RBL1 PMC8138161__F3 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway ULK1 F2 ULK2 MTOR FADD BAX PMC12024444__F2 YAP/TAZ have different regulatory effects on different stages of osteogenic and chondrogenic differentiation DPM1 VGLL3 RUNX2 NFATC1 MSC COL1A1 COL10A1 SOX9 MX1 PMC7366109__F5 KEGG signaling pathway enrichment network of Pre-No EGF BAD PRKCE NR3A2 MYC BCL2L1 PTEN CCL2 RB1 MTOR INSR PRKCA PIM1 KDR DIO1 MDM2 CD40LG IL4 JUN FOS VEGFA CXCL2 NR1C1 RXRA MAPK4 RELA PPARG PMC8138161__F1 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway ULK1 ATG12 ATG3 LAMP2 AMBRA1 ULK2 UVRAG MTOR DKFZp686F0183 PMC3445776__F1 The Hedgehog signaling pathway SUFU PTCH1 SMO PMC8872619__F5 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells BAD PLAT CDK2 ERG CCND1 BCL2 PTEN NKX3-1 TF PMC8535862__F2 Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer ULK1 FOXO3A KLF10 AMBRA1 SRC BCL2 NRBF2 DIRAS3 UVRAG ATG14 SUMO1 STAT3 PMC11036658__F9 Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer CDC2 MTOR BAX PMC4335789__F1 Mechanisms that promote resistance to PI3K pathway inhibition PTEN MTOR PMC8138161__F6 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway TLR4 MTOR CA12 PMC4905241__F1 Cell cycle-dependent regulation of E2F1 PRMT1 ATM MYC C6 SKP2 PMC4905241__F2 DNA damage-dependent regulation of E2F1 PRMT1 ATM APAF1 SETD7 MDM2 BCL2 NEDD8 ATR BAX PMC11395567__F2 Simplified illustration of the signalling pathway depicting priming and activation of the NLRP3 inflammasome NLRP3 TRADD IRAK1 IRAK4 BRCC3 MYD88 FADD GSDMD PMC11279438__F1 Vitamin D’s role in skeletal muscle NR1i1 FOXO3A CUBN DBP PMC11279438__F2 Relationship between oxidative stress and weakness of muscle HEL-S-44 TNF SIRT1 PMC8328045__F5 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron TLR4 CD34 ABCG1 ATF1 TNF IL1B PMC4905454__F3 Cancer stem cells and signaling pathways in radioresistance NOTCH2 CD44 NOTCH1 MTOR TGFA BAX PMC7721054__F2 Anatomy of an mRNA ELF2 ELF3 EIF4E PMC8328045__F3 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron NLRP3 TLR4 VCAM1 SYK MYD88 PMC11279438__F3 Antioxidative role of vitamin D in muscle dysfunction MFN1 MFN2 KEAP1 FOXO3A SIRT1 OPA1 PMC7985100__F3 Signaling pathways and gene regulation on NLRP3 inflammasome NLRP3 RIPK1 DICER1 RIPK3 TXNIP MLKL PMC8440972__F3 Houttuynia cordata Thunb: An Ethnopharmacological Review KEAP1 BAX PMC4584313__F2 Hedgehog Signaling in Malignant Pleural Mesothelioma SUFU GLI3 SMO PMC11566155__F10 Novel function for Alpha-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction NCK2 RHO EPHA4 PMC4905454__F1 Cancer stem cells and signaling pathways in radioresistance BAD CDK2 BRCA2 PIR MTOR TGFA BAX PMC4849016__F2 Regulation of RNase 7 induction ATF2 EGFR STAT3 PMC10394732__F2 Mechanisms involved in mutant p53 exerting GOF effects IL7 MYC CDC2 SMARCD1 TF BAX PMC3245324__F2 Ischemic preconditioning (IPC): signaling pathways and targets SRC PTEN MTOR PMC5541046__F7 Working model of the EphA4–ephexin1 signaling pathway and BDNF-TrkB signaling pathway in the model of depression FYN CDK5 BDNF EPHA4 PMC8699295__F3 TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer EGF EGFR FOXC2 TRPM7 SOX4 PMC11720051__F2 Diagram of Hippo Signaling Pathway “on” & “off” states MTF1 MOB2 NF2 LATS1 LATS2 PMC7579731__F1 Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations BRAF APC EGFR GSK3B GRB2 MTOR PMC3602516__F1 Identification of Small Molecule Activators of BMP Signaling BMP2 SMAD6 SMAD4 ID1 SMAD1 DKFZp781O1323 PMC11173247__F8 Wound-induced genes involved in plant–insect interactions in arabidopsis WT and lox2 mutants MYB RGL3 MYC PRX PMC5214941__F2 Proinflammatory role of extracellular interleukin (IL)-1A IL1R2 IL1R1 HAX1 PMC4050127__F1 Targeting LIM kinase in cancer and neurofibromatosis NF1 LIMK2 ARHA RAC1 PMC7655196__F1 Summary scheme of MerTK-mediated macrophage HSC crosstalk pathway in fibrotic NASH MERTK TGFB1 ADAM17 PMC7326904__F1 Evaluation of Silencing Effect of miR-133a-5p Mimic on TIM-3 Expression in AML (HL-60) Cell Line NLK TRADD GRB2 GCK ECSIT TNF TRAF2 JUN PMC4045235__F3 CUL7-OBSL1-CCDC8 pathway and its predicted role in cell growth CUL7 IRS1 INSR PMC10925900__F7 Amyloid-Beta-Induced Dendritic Spine Elimination Requires Ca2+-Permeable AMPA Receptors, AKAP-Calcineurin-NFAT Signaling, and the NFAT Target Gene Mdm2 HEL-S-62p NFATC4 MDM2 NFATC3 PMC8526962__F4 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway BAD ALK POLK EGFR CASP9 PMC8526962__F5 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway EGF GRB2 TGFA PMC6540369__F1 a Biosynthetic pathway of glycyrrhetinic acid constructed in S GIG8 IPP PMC6703648__F7 Proposed model for the role of the Rb/E2F pathway in the coordination of proliferation and differentiation during neurogenesis DLX2 E2F7 DLX1 PMC4917665__F2 Metabolic pathway of aerobic glycolysis, FAS and FAO ME1 CPT2 ACLY HEL-S-133P HK2 FASN PMC9290266__F8 RA signaling pathway combined with Wnt signaling pathway regulates human-induced pluripotent stem cells (hiPSCs) differentiation to sinus node-like cells TBX18 SHOX2 CACNA1G PITX2 TBX3 TBX5 SCN5A HCN4 BMP4 PMC8670263__F1 CGAS–STING pathway: more than fighting against viruses and cancer TBK1 CGAS IRF3 PMC8253380__F1 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies ASCL1 SHH GPR49 HES1 PMC8253380__F2 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies SUFU LRP5 LRP6 PORCN SMO PMC5144577__F1 Canonical Notch signaling and Notch conservation between human and Monosiga brevicollis EGF NUMB JAG2 PMC5874734__F1 Induction of necrosis by L IMPACT RIPK3 IRF3 MLKL PMC6678606__F1 Stearoyl-CoA desaturase 1 (SCD1) as a molecular target for anticancer therapy EGF EGFR GSK3B CCND1 HEL-S-53e PTEN PMC6514153__F3 Reelin signaling pathway in Golgi Dynamics and morphology LIMK1 VLDLR GSK3B SRC RAC1 DAB1 CDC42 CLASP2 PMC11087106__F7 High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NFKB and PI3K/AKT/mTOR signaling pathways in rats TNF MTOR BAX PMC5474195__F2 Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy PTEN EIF4E RHEB PMC5797575__F8 Proposed scheme of the possible mechanisms associated with the effects of asiaticoside (AS) on attenuation of cell growth inhibition and apoptosis induced by AB1-42 in human brain microvascular endothelial cells (hBMECs) TLR4 TRAF6 MYD88 PMC4490961__F2 Interaction of the TFF2-CXCR4 axis with the active RAS-RAF-MEK-ERK pathway in the serrated pathway of colorectal cancer EGF TFF2 CXCR4 EGFR PMC7281527__F1 Canonical microRNA (miRNA) biogenesis pathway DGCR8 DROSHA STAR PMC4308035__F1 Proposed pathways by which prostate cancer cells activate AR signaling, including variants (AR-Vs), and thus acquire resistance to AR-directed therapy IGF1 IL6 PMC4199664__F1 Cell cycle regulatory pathways TIGAR NF1 SCO2 EGFR CDK4 CDC2 HIF1A MTOR CDK6 PMC7565308__F5 Systems biology analysis MYOF MYH9 EPCAM HEL-S-15 TFRC SRPRB HEL-S-94n FDPS RPL23 SND1 HEL114 NOS2 FASN ANXA1 ANXA11 HEL-S-30 TES HEL-S-87p LMNA RAB21 CASP3 YWHAQ TPD52 HEL113 GRB10 RAN POLM ALDH2 PMC8406742__F2 Neutrophil Extracellular Traps in Cancer HMGB1 MPO EGFR IL1B CEACAM1 PMC7411791__F1 Toll-like receptor (TLR) signaling in response to viral infection TBK1 RIPK1 TLR4 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 PMC8748997__F8 The proposed model TYK2 IFNAR2 MTOR IFNAR1 ARG1 SOCS1 PMC3845556__F1 Targeting the PI3K-AKT-mTOR signaling network in cancer TSC2 TSC1 IGF1 IGF2 PTEN MTOR RHEB PMC7565308__F6 Global subnetwork analyses BIRC5 MYC TRAF3 TRAF6 PLCG2 BCL2L1 PTEN MTOR BTK BCL10 MAPK1 RPS6 CASP8 BAX NR3C1 FKBP5 EIF4E IL6 TNF CASP10 CD79A FAF1 NFKBIA CARD11 PRKCB LYN BCL2 SYK TNFAIP3 FADD PMC7859290__F1 Biosynthesis of the molybdenum cofactor (Moco) and metabolic pathway of sulfur amino acids and purine degradation MOCS2 MOCS3 GPHN PMC4033628__F2 Synthesis of representative structures along the Golgi-centric core M1 and M2 glycan synthesis pathways POMGNT2 POMT1 POMT2 FUT9 B3GAT1 PMC7897327__F2 m6A RNA modification regulates hematopoietic system development YTHDF2 METTL3 EIF2A CCND1 BCL2 PTEN AXIN2 MAVS PMC4033628__F3 Representative core M3 structures that are dependent on multiple initial activities based in the ER POMGNT2 POMK B3GALNT2 POMT1 LARGE2 POMT2 PMC7349681__F2 Types of extrusion S1PR2 RHO PMC12254754__F2 Schematic illustrates that inhibition of GLUT1 results in an increase in the tumor OXPHOS pathway, leading to excessive production of ROS, which subsequently promotes TNFAlpha-mediated cell death CXCR3 CXCL10 CXCL9 PMC6933354__F6 Schematic model indicating that SPRY4‐IT1 competitively binds to miR‐217 and TCF7L2, consequently regulating the Wnt/B‐catenin signalling pathway to promote stemness of breast cancer cells APC GSK3B TCF7L2 PMC9542654__F4 Exploration of hub genes involved in PCOS using biological informatics methods BAD CD37 MYC PTEN RAC1 EIF4E IRS1 BRCA1 RHEB RXRA TSC2 TSC1 BCR MDM2 SYK CP RBL2 CD19 PMC8383754__F3 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis FOXO3A MMP9 CD44 CREB1 MTOR PS1TP5BP1 IFNG HEL-S-102 CASP3 MMP2 opn APP CASP9 CCND1 NOS2 JUN IL1B CYCS APOE PMC9608206__F2 Clinical implications of the interaction between PD-1/PD-L1 and PI3K/AKT/mTOR pathway in progression and treatment of non-small cell lung cancer MYC PTEN EIF4E MXI1 STAT3 PMC11002130__F4 tsRNAs as inhibitors of MAPK pathway activation via targeting MAPK-related proteins CCND1 RHO BDNF CDC42 PMC8383754__F5 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis PIK3R1 NFE2 FOS NFE2L2 MAPK3 VEGFA IL6 MTOR HMOX1 MAFA IFNG HEL-S-162eP PRKCB TIMP1 MAFK RELA DBP BCL2 JUND JUNB NOS2 JUN MAFG PMC2659375__F2 MET as a target for treatment of chest tumours GRB2 SRC RHO PXN CDC42 PMC8317503__F1 Knockout Gene-Based Evidence for PIWI-Interacting RNA Pathway in Mammals SPOCD1 DDX4 TDRD12 TEX15 TDRD6 TDRD1 DNMT3L HIG-1 PMC7393201__F7 Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1A pathway FGF21 FGFR1 IL1B TGFBI BAX PMC4307801__F1 HER2-Positive Breast Cancer: Current Management of Early, Advanced, and Recurrent Disease BAD GRB2 CCND1 SRC PTEN MTOR PMC5486146__F1 Thyroid cancer hystotypes and their causative genetic events BRAF PTEN PAX8 PMC4270129__F1 This figure shows the VEGF pathway for angiogenesis CXCL1 APAF1 CXCL8 IL8RB PMC4829549__F2 MET signaling pathway BAD HGF MDM2 GRB2 SRC MTOR STAT3 PMC8728240__F2 Priority index: database of genetic targets in immune-mediated disease TH PML MYC TRAF2 PMC3526895__F9 Schematic model of the signaling pathway activated by redox/metabolic imbalance and its possible positive impact on human lifespan PPARGC1A GCLC NFE2L2 PMC9312948__F2 Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors MYC SRC HIF1A SIRT3 PMC9228579__F3 Immunobiology of Nipah Virus STAT1 STAT2 IRF9 STAT4 TYK2 STAT3 PMC8074097__F6 Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy BAD IL16 RPIA BAX PMC4690264__F1 Type I IFN signaling pathway and transcriptional changes of selected ISGs in the spinal cord of TMEV- compared to mock-infected SJL/J mice ISG15 MX2 MX1 PMC6747431__F5 The different expression of HH (hedgehog) signaling PLG HEL-S-11 RAB20 SMO SHB PMC3464048__F1 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets RAF1 MTOR FADD STAT3 PMC3464048__F2 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets MYC SRC STAT3 PMC1849962__F5 Regulatory networks model of GSL biosynthetic pathway in Arabidopsis accession Columbia F2 F11 CBL PMC12242330__F1 Phenylpropanoids metabolism: recent insight into stress tolerance and plant development cues CAD PRX PMC12093320__F1 Genes encoding downstream NFLs evolve at a slower and more consistent rate comopared to genes encoding upstream NFLs HHIP TRIM38 DKK3 SIGIRR PTCH1 LATS1 AXIN2 LATS2 SOCS1 CITED2 HES1 PMC6044425__F2 The N-linked protein glycosylation pathway DPM1 ALG1 ALG3 DPAGT1 ALG13 ALG6 ALG10 ALG5 DOLK DPM2 GFPT1 DPM3 PMC8470960__F2 Effects of Intermittent Fasting on Brain and Cognitive Function MTOR BDNF HEL-S-5 PMC2756474__F7 CREB Mediates Prostaglandin F2Alpha-Induced MUC5AC Overexpression COX2 MUC5AC IL1R1 IL1B PMC4110182__F1 SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease HNRNPR LSM6 GEMIN6 GEMIN7 GEMIN8 LSM1 LSM3 LSM8 LSM5 LSM7 LSM4 GEMIN2 LSM2 GEMIN5 PMC6469489__F1 Multiple pathway stimulation of ADAM activity, leading to sAPPA proliferation and notch stimulation EGF EGFR APP PMC11604893__F1 Tumor energy metabolism: implications for therapeutic targets PDC HEL-S-30 MTOR HEL-S-133P HEL-S-162eP PMC9072795__F1 Molecular signaling in temporomandibular joint osteoarthritis MED12 ADAMTS4 IHH FGFR1 ADAMTS5 GLI3 FGFR3 SMO ADAM10 GAL PMC4440618__F5 Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Host Cell Wnt Signaling Pathway Regulator Cytoplasmic Activation/Proliferation-Associated Protein 2 (Caprin2) APC LRP5 LRP6 CAPRIN2 PMC11604893__F3 SWI/SNF complex regulating tumor metabolismThe purple gene and arrow represent glucose metabolism SMARCA4 SCD HEL-S-30 SMARCD3 FBP1 ACLY PPARG PFKP HEL-S-133P ACOX1 FASN PMC6225799__F6 Activation of the interferon-ɣ/STAT1 pathway AK2 SOCS1 BAX PMC5817726__F2 Role of Bruton’s tyrosine kinase downstream of the B cell receptor BTK PI3 CARD11 BCL10 BCR LYN MYC SYK PLCG2 PTEN RAF1 CD19 PMC10855951__F5 Transcriptomic Analysis Provides Insights into Candidate Genes and Molecular Pathways Involved in Growth of Mytilus coruscus Larvae E2F4 KIF7 SUFU SMAD2 GLI3 KIF3A SMAD4 SMO PMC6224961__F2 Regulation of priming and fusion of insulin granules by glucose and the incretin GLP-1 SNAP25 CFTR PMC7259377__F6 GLS1-mediated reduction of oxidative stress is associated with increased phospholipid synthesis and the activation of folate and methionine cycles CTH HEL-S-61p HEL-S-182mP PTDSS1 MAT1A HEL-S-64p PCYT2 PISD TG PTDSS2 MTHFS PEMT PMC7246647__F2 Oncogenic FGFR signaling in gastrointestinal stromal tumors (GISTs) FGF4 CTCF PMC6206165__F9 Model showing possible mechanism for regulation of ovarian development by four key miRNA/gene pairs SFRP4 NR5A1 APC SMURF2 SMAD4 FZD4 SMURF1 PMC7246647__F1 Fibroblast Growth Factor Receptor (FGFR) structure, ligand binding and signaling GRB2 TK1 PMC4221550__F3 smicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma EGF c-fgr MOS BRAF NGF EGFR MYC GRB2 PMC8131586__F6 Illustration of the positive feedback loop between tamoxifen-resistant ER-positive breast cancer cells and M2-like TAMs EGF EGFR ARG1 STAT3 PMC10244098__F2 N7-methylguanosine modification: from regulatory roles to therapeutic implications in cancer TGS1 WDR4 RNMT PMC7072743__F2 Activation of the mechanistic target of rapamycin (mTOR) TSC2 RICTOR TSC1 MTOR IRS1 RHEB MLST8 PMC2857869__F4A Metabolic Engineering for Production of Biorenewable Fuels and Chemicals: Contributions of Synthetic Biology NADK HPR PMC3049838__F3 Wnt signaling pathway activation in R1A deficient tumor cells APC GSK3B LRP5 PMC3800433__F1 The central role of group 2 innate lymphoid cells (ILC2s) in type 2 immunity AHR EGFR IL33 IL25 TSLP PMC2742089__F3 A biochemical pathway of secreted proteins that regulate D-V patterning in Xenopus BMP1 BMP2 BMP7 BMP4 PMC5607250__F9 Predicted regulation relationships between differentially expressed miRNAs and target genes based on KEGG pathway PRLR XDH PMC8127529__F2 Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection ACE2 ADAM17 TMPRSS2 PMC4632976__F1 The intracellular parasite Toxoplasma gondii depends on the synthesis of long chain and very long-chain unsaturated fatty acids not supplied by the host cell ELOC ELOA PMC6690620__F1 Biochemical pathway of the creation of homocysteine and specific enzymes/vitamins necessary for conversion to methionine vs PMC8642426__F2 Pharmacological insights into autophagy modulation in autoimmune diseases CGAS ULK1 ATG16L1 ATG12 PARK2 ATG3 IRGM DKFZp686F0183 NOD2 TLR3 PMC2785619__F2 Up-regulation of TGFB signaling in Timp3−/−-AB hearts BAMBI RUNX3 RUNX2 SKIL FOS SMAD2 LIF MAPK3 TGFBR2 ENG BMP4 FKBP1A IFNG FST NOG CREBBP opn SKI SMAD1 JUN INHBA PMC4249087__F8 The UPR-induced HAdV infection boost by GCA GCA PMC3520888__F1 Escorting Ras CHMP6 RIN1 EGFR VPS4A PMC3192435__F2 Targeting the PI3K/Akt/mTOR pathway to treat lymphoma TSC2 TSC1 RHEB PMC6788945__F3 Sex-differential regulatory network FOXO4 CTSS TPO SCEL KIZ CBLN3 PMC3535856__F6 Proposed mechanism for MCME-mediated inhibition against migration of CL1 cells SRC PMC6962451__F5 The proteome landscape generated by the direct comparison between cells differentiating in alginate capsules and Matrigel differentiated-cells ATM RHO PTEN MTOR NR1C1 BRCA1 RXRA PMC5682960__F7 Working model of the action of PEDF + DHA in enhancing corneal nerve regeneration SPRR1A SEMA7A NGF NPY PLG BDNF VIP PMC2575530__F2 Insulin-like growth factor-I signaling pathway involved in breast cancer BAD IGF1 GSK3B GRB2 PTEN SOS1 MTOR IRS1 PMC9113874__F7 Transactivation at C-TAD Domain of HIF-1A by Factor-Inhibiting HIF-1A (FIH-1): A Potential Target for Therapeutic Intervention in Cancer TH UNK HIF1A PMC7037626__F1 Protein interaction network of MMPs, collagen II and aggrecan SPARC HAPLN1 NGF MBP MMP19 LPA UMOD MMP17 PRELP MMP3 TNFSF6 MMP2 CRP ACAN PLAUR ITGA2B MMP26 BMP2 MMP20 PCOLCE HBEGF BCAN ADAMTS4 CHAD TNR PZP ITGAV CXCL12 PMC3055988__F2 Further implications of G-/GM-CSF-induced JAK-STAT signaling in peripheral sensory neurons KCND2 SCN10A TRPV1 KCNK2 STAT3 PMC10304636__F4 Schematic diagram representing cardioprotective molecular mechanisms of GLP-1 analogs in cardiomyocytes MFN1 MFN2 BAD GPX1 MTOR GLP1R DRP2 BAX PMC9258689__F5 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data PYCR2 SRM ALDH18A1 MAP3K7IP1 PMC8330049__F1 Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies PLN NF1 GRB2 SRC PMC9258689__F4 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data HEL-S-26 GPX4 LAP3 SRM GPX1 GATA1 PMC8180257__F7 MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus MEIS1 ROR2 FOXJ1 ROR1 PMC4949768__F1 Central carbon metabolism model for M CIT HPR MAL PMC5849286__F1 Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases PC DES SMS HEL-S-5 PMC4947675__F1 Non-canonical autophagy in the clearance of dead cells ULK1 UVRAG DKFZp686F0183 PMC5899024__F6 For Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders CNTF HEL70 LRRK2 BDNF PMC8412110__F5 Cdc42 signalling in cell migration DOCK10 ARHA RAC1 CDC42 STAT3 PMC3690396__F7 Regulation of the Hippo pathway by cAMP-PKA signaling LATS1 RHO LATS2 PMC8038986__F1 Contribution of cell death signaling to blood vessel formation RIPK3 BCL2 MLKL BAX PMC8990811__F1 Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation TH CD58 CD6 APC CTLA4 TIGIT SPN HLA-DRB1 HLA-B PTPRC CD2 CD22 CD40 CD80 CD226 ICOS PDCD1 PMC6917045__F2 Interplay between the UFM1 pathway, ER stress and cell fate UFM1 ATF4 SRC UBA5 UFC1 PMC6917045__F3 Control of proteostasis by the ufmylation pathway UFM1 RPL26 UFL1 UFC1 TF PMC12185702__F6 MAPK/OIS/SASP axis in pLGG cells PLK1 GSK3B IL6 IRS1 GFPT1 AURKB CDK6 ATM CDK2 HEL-S-44 CDK4 POU5F1 ATR IL1B PMC3335094__F3 Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation NF1 CD14 NLK MOS MAX FLNA ATF2 GRB2 ECSIT MEF2C PMC11648424__F2 Compound target–protein–protein interaction functional enrichment network of A PIK3CD MAPK9 HDAC3 MAPK3 MAPK14 CPT2 IRAK4 DRD1 PTGS1 TRPV1 CBFB CCR1 HEL-S-26 ITK FLT1 HPGD FGFR1 SCD MDM2 SRC EPHX2 HDAC2 MAPK1 AXL CA7 ABCB1 NEK1 NAAA SNCA QPCT HEL-S-28 SLC10A2 HTR7 CDC25B HMGCR AURKB TTL MAPK13 SLC6A3 PLAA SETD7 BRD3 DHFR NR1C2 ALDH3A1 MAPK11 DUSP3 SIRT1 LAT AKT3 CDC42 TERT BRD4 FABP1 P2RX3 TBK1 BAD BRAF REN TTK TGFBR1 ACKR3 HDAC11 ACHE MTOR HEL-S-104 CALCRL CNR1 CLK2 BTK F2 PTPN1 CDK4 TRHR CDC2 KIT CXCR1 NTRK1 GSK3A PARP1 NR1C1 HDAC1 RPS6KB1 CREBBP MAP2K1 LCK PARP2 SYK PPARG DYRK2 MME ADRBK1 PMC5688007__F2 Mitochondrion: a central architect of copper homeostasis SCO1 ATP7A HEL-75 COX19 HEL-S-44 SIRT3 PMC4603304__F5 Signaling pathway analysis of the potential mature EBOV miRNA target genes HEL-S-62p SELPLG RIPK1 TBP NFKBIE CRYAA PMC6349928__F1 Non-coding RNAs as integrators of the effects of age, genes, and environment on ovarian aging AMH FOXO3A PTEN PMC2899674__F1 Molecular pathway for arterial, venous and lymphatic cell fate determination in vertebrate embryo FOXC1 SOX18 PROX1 SOX7 EPHB4 PMC4367606__F2 Tumor cell ligands recognized by human GD T cells MICB MBP APC ULBP1 MICA ULBP3 NECTIN2 IPP PMC9170129__F10 Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens NPW POMC NPBWR2 CRH MC2R JUN PMC6487485__F1 Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome CYP27A1 GCA CYP8B1 CYP7B1 HSD3B7 PMC11849638__F9 Schematic depiction of the PKA/SHP2/STAT1 pathway STAT1 PDE4D COX2 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC5055439__F1 Stem cell metabolism PML HIF1A MTOR PMC4404318__F1 Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework CD14 BTK TLR4 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 TIRAP PMC8183764__F1 Fructose and metabolic diseases: too much to be good ALDOB PKLR GCK KHK FASN PMC6388657__F6 IPA to identify the signaling pathway associated with the differentially expressed proteins across all the conditions studied TH HEL111 CFH TEF AHSG SERPINF2 PMC3877388__F6 Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling CCL20 LRP6 IL6R STAT3 CD24 PMC6288499__F1 Epidermal growth factor receptor pathway in patients with wild-type and mutant BRAF and KRAS BRAF EGFR PMC8809363__F1 Recent Advances in the Role of Arid5a in Immune Diseases and Cancer STAT1 TLR4 ARID5A PMC6910185__F4 A diagram of mechanistic insight of genistein (Gen) to induce apoptosis in cancer cells HIPK2 ATM PTEN TNF MTOR ATR IL1B DNASE1 HK2 BAX PMC6910185__F5 Molecular targets of genistein (Gen) in cancer cell cycle EGF ATM CDK2 EGFR MDM2 NOTCH1 PTEN CDC2 ATR PMC6910185__F6 Schematic representation of antiangiogenic activity of genistein (Gen) in cancer VASP YAP1 FOS MDM2 SRC ARHA RHO PTEN MTOR STAT3 PMC6910185__F7 Illustration of antimetastatic potential of genistein (Gen) in cancer MAF TLR4 ATF2 MMP9 EGFR MYD88 IL1B NQO1 TIRAP PMC12185702__F2 Mapping of the multi-omics MAPK/OIS/SASP axis in pLGG cells FOXO4 E2F4 MARCKS PLK1 ATF2 MAPK3 GSK3B MYC MAPK14 HIF1A WT1 CDKN2A MMP3 TBP TCF20 HTT NOTCH1 HEL-S-44 PAICS JUNB SP1 MYOG MAPKAPK2 HCFC1 FOS ATF3 IRS1 ARID1A AURKB GFPT1 MCM2 BCL2A1 MAFK KPNA2 ATR PML CXCL1 BAD BRAF KIFC1 OPTN CEBPB IKZF1 ATM CDK4 CDC2 JUN RBL2 KDM1A RUNX1 FOXO3A ADD2 PDK4 GAP43 HDAC1 AURKA EGLN1 GATA2 FOXA2 NFATC2 MARCKSL1 NFKB1 RELA NFIL3 JAK1 SRPK2 CAMK2A PMC5388758__F5 Gene networks associated with intestinal processes and diseases HEL-S-62p C9 C4B_2 AGER C7 C6 PTEN POR C1S RORA PMC11765784__F2 Mechanism of amino acid signal sensing in PCa VWCE ATF4 GCN1 RHEB PMC7035310__F3 Main anatomical connections—outputs and input pathways (shown as arrows) of the zona incerta DCN SI PMC4716033__F2 p21-activated kinase 4 signaling pathways in gastric cancer EGF HGF MMP2 SMAD2 EGFR CCND1 PAK4 TGFB1 PMC7946393__F1 Membrane trafficking regulation of primary cilium assembly in intracellular pathway RAB35 EHD1 AHI-1 KIFC1 CEP97 EHD3 RAB23 PACSIN1 INTU LPA IFT172 SNAP29 ARL13B TMEM67 CEP164 PACSIN2 CEP290 IFT20 PMC2901320__F5 CXCR4 pathway is affected in CD34+ cells from CAD patients FYN CXCR4 VAV1 RHO RAC1 HRAS CRK STAT3 PMC7969034__F8 Working model of IFI16/p204 recognizing dsDNA to active downstream signaling pathway TBK1 IRF3 IFI16 PMC6928971__F2 Overview of hedgehog signaling pathway DHH IHH SHH SMO PMC7564905__F1 Signaling mechanisms mediating the actions of neurotrophins STAT1 BAD GSK3B MYC MDM2 GRB2 MTOR FOXO1 STAT3 BAX PMC8397941__F3 Mechanistic Insight into the Effects of Curcumin on Neuroinflammation-Driven Chronic Pain TLR4 CX3CR1 TF PMC4689171__F2 IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas BTK CARD11 BCL10 IRAK1 IRAK4 MYD88 PMC11280978__F1 Mechanism of action by which MNPs cause neurotoxicity BDNF PMC3157841__F1 Expression Level Drives the Pattern of Selective Constraints along the Insulin/Tor Signal Transduction Pathway in Caenorhabditis SGK1 PMC8692646__F1 mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication TSC2 ULK1 TSC1 TFEB PTEN RHEB PMC10862883__F5 Acceleration within PREs widely affects the Notch signaling pathway CTBP2 NUMB MAML3 CTBP1 JAG2 TLE6 LFNG MFNG RBPJL NOTCH3 ADAM17 HES1 HES5 ATXN1 MAML2 NOTCH1 DVL2 SNW1 HDAC2 NCOR2 MAML1 NOTCH4 KAT2B RBPJ CIRSR DTX1 DTX2 DTX3 HDAC1 DVL3 DVL1 CREBBP HEY2 EP300 APH1B TLE2 PMC6328495__F1 The regulation of the mevalonate pathway and the role of mevalonate-derived metabolites in cell proliferation UBIAD1 HMGCR PMC6435658__F7 Illustration summarizes the molecular mechanism and signaling pathways underlying the effect of Dis on HCT-116 cells GIG8 HDAC2 TNF HDAC5 SETD2 ID1 HDAC1 FADD BAX PMC4819171__F2 Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells CS MAX FLNA PIR GRB2 ECSIT TRAF2 PMC7912927__F1 PI3-K/Akt/mTOR signaling cascade TSC2 RICTOR TSC1 HEL-S-28 PTEN MTOR RHEB PMC2866836__F1 Mitochondrial Ca2+ channels/transporters and role in mitochondrial function MCU DCC PMC8212145__F4 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge MYB MHC2TA KRT19 RPS6KA4 MAPK14 NBN RB1 IFNG CCR1 PRKCA PRTN3 FLT1 SRC GREB1 IRF7 STAT2 MAP3K7 KCTD6 ABCA3 TCF7L2 BRCA1 LAMA1 MMP14 TBX21 PRKCB CDKN1A GFER ATR PML CXCL1 IKBKE PGR MTOR XBP1 RARA FOXC1 CAMK4 ATM FOXA1 CXADR CCND1 PRF1 ELANE CD40LG PRKDC MMP9 INCENP PTGS2 PISD HCTP4 STARD7 HEL-S-102 EP300 LAMB1 TFF1 LCK PMAIP1 SHC1 CD24 PMC5796233__F1 Tumor progression toward cancer metastasis VCAM1 PTEN PMC5796233__F2 Overview of anticancer properties of pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene; PS) MUC1 MMP9 EGFR PTEN PMC6821383__F1 Complement system and therapeutic targets in bacterial meningitis HEL-S-62p C9 C4B_2 C7 C6 C4A CP PMC3259218__F1 Gemcitabine metabolic pathway genetic polymorphisms and response in non-small cell lung cancer patients CDA RRM2B RRM1 RRM2 DCTD SLC29A1 PMC3147552__F8 Schematic overview of IDO induction by H STAT1 TLR4 STAT2 IRF9 IRF3 TYK2 MYD88 JAK1 PMC3833059__F7 Scheme of the proposed LIF signaling pathway in trophoblasts SOCS3 LIF GRB2 MTOR TF STAT3 PMC7793792__F1 Regulatory mechanisms of ferroptosis GPX4 STEAP3 SLC7A11 GSK3B KDM3B IREB2 DKFZp686F0183 TF SIRT3 PMC6543449__F2 IRFs in the TLR and IFN pathways TLR7 TLR4 TLR9 STAT2 IRF7 IRF9 IFNGR2 IFNAR2 IRF2 IRF-1 TLR3 TIRAP PMC9685675__F6 Roux-en-Y gastric bypass-induced perturbative changes in microbial communities and metabolic pathways in rats ASAH2 PLB1 LASS1 DEGS2 KDSR PMC8226792__F4 Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins TBK1 FOXO4 CHUK BAD RALA BCL2L1 RALBP1 TNFSF6 PLD2 KSR1 PLCE1 ETS2 AFDN SOS2 RIN1 RRAS SHOC2 ARHA TIAM1 RELA PIK3CA RAF1 REL PLA2G10 RGL2 CDC42 EXOC2 PMC3355325__F2 Two distinct DC semi-maturation pathways induce different types of regulatory T cells IL10 CCR7 RELB TNF PMC6819419__F1 Necroptosis molecular pathway HMGB1 TLR4 TRADD IL33 RIPK3 FADD TLR3 MLKL PMC5295594__F2 Regulation of ecdysteroidogenesis TSC2 TSC1 SMAD2 PMC9289614__F1 Editorial: Autophagy-Mediated Cell Survival and Death in Disease Progression and Treatment ULK1 ATG12 ATG3 ATG101 ATG14 DKFZp686F0183 PMC11016524__F2 Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example TSC2 CSH2 TSC1 PTEN PMC2430503__F1 Resistance to ErbB-targeted cancer therapeutics MTOR IRS1 PMC8212145__F5 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge PIK3R1 MAPK9 BAD BRAF FOXM1 MAPK8 PGR ACACA HEL-S-1 MAPK3 GSK3B NRAS MAPK14 PRKAA1 SMAD4 MTOR PDPK1 PRKCA ACACB CCNB1 PTPN11 SRC CCND1 COL6A1 MAPK1 RPS6 JUN FOXO3A YBX1 CDKN1B ERBB3 GSK3A NRG1 WWTR1 TSC2 RICTOR RPS6KB1 PRKCB RPS6KA1 ERBB2 RELA LCK BCL2 RAF1 SHC1 AKT3 STAT3 PMC9113527__F1 Enhancing HR Frequency for Precise Genome Editing in Plants RAD52 RAD51 PMC3163779__F1 Thyroid hormone action is modulated by the deiodinases TRH PMC6567815__F2 Synthesis and function of NAD+ in the cytoplasm and nucleus NAMPT HEL-S-90n NADSYN1 PMC6567815__F3 Synthesis, metabolic pathways and function of acetyl-CoA PC HEL-S-278 ACSS1 ACSS2 ACLY SIRT1 HEL-S-162eP SIRT3 PMC11394240__F1 YAP/TAZ mechanisms in solid tumors, particularly HCCs, in hypoxic environments LATS1 RHO LPA LATS2 PMC11394240__F3 Phosphorylation of YAP/TAZ under hypoxic conditions SIAH1 IGF1R BIRC5 LATS1 RHO LPA LATS2 HMGCR PMC5711827__F1 Innate immune signaling pathways that drive type I IFN responses in mycobacteria-infected host cells TBK1 ESX1 CGAS TLR4 IRF3 NOD2 PMC5949009__F6 Schematic of accelerated tissue regeneration pathway via the dynamic and adaptive HMGB1–CXCL12–CXCR4–GAlert axis HMGB1 CXCR4 CXCL12 PMC5628280__F1 Signal transduction by flagellin in mammalian cells TLR5 IL16 TLR4 NLRC4 CCL20 TRAF6 IL1B PMC3130491__F4 Schematic of leptin intracellular signaling through the STAT3 and PI3K-PDE3B-cAMP pathways in the hypothalamus PDE3B POMC SOCS3 NPY IRS1 STAT3 PMC5933896__F3 Signaling and regulatory network of gp120 at apoptosis pathway ITGAM CD1D CX3CL1 FPR1 SLC1A2 IL2RG BCL2 NOX4 FPR2 MAVS TERT PMC7837452__F7 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins FES PCBP1 NDOR1 NUBP1 BOLA2B CIAPIN1 PMC7837452__F5 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins NFU1 PMC5381815__F2 TAM Receptor Tyrosine Kinases as Emerging Targets of Innate Immune Checkpoint Blockade for Cancer Therapy STAT1 SOCS3 SOCS1 PMC8207720__F3 Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma MMP2 APC CXCR4 HNRNPL USP47 TUG1 EZH2 SIRT1 PMC2864432__F3 Insulin/IGF1 signalling pathways and AD BAD IGF1R IGF1 GRB2 SHE PMC9156618__F2 Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome F10 EPO AGTR1 FLT4 CXCL8 PRKAA1 IFNG NLRP3 ADAMTS13 HGS IL7R MAPK1 FURIN CSF2 CTSL ADAMTS2 PLG CXCL10 VEGFA FCGR3B HLA-B HLA-A IL2RA TNFAIP3 PSMD1 PYCARD MPO CS REN CSF3 INS HLA-DQB1 MTOR AGTR2 ISG15 BTK PLAT TLR7 TLR4 STS F2 NCKIPSD F3 VWF hEMMPRIN ACE2 CD19 HMGB1 IL10 CD14 RBPJ PRKAA2 NFE2L2 SLC6A19 IFNB1 CASP3 FCGR3A HLA-DPB1 IL7 CYP3A4 CTRL CD40 MME MEFV CCL3 PDCD1 PMC8209414__F2 Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis GOT2 F2 ASNS PRODH ACSS2 HEL-S-133P HK2 CD36 PMC4178909__F1 The role of the VHL elongin BC complex in the HIF1 pathway in normoxic, hypoxic, and pseudohypoxic conditions CUL5 ELOC VHL PFKL RBX1 PMC5180601__F6 Condition-specific dependency network (CDN) for indisulam for drug-sensitive cell lines EDN1 EGLN3 EP300 ASPH VHL VEGFA CREB1 CA9 HIF1A JUN HEL-S-133P EGLN1 PMC4545821__F5 2A-DNT on transcript expression, protein expression and nuclear signaling mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) peroxisome proliferator-activated receptor (PPAR) pathway UBC PLTP UCP1 HEL-S-28 ADA PMC4869267__F1 Scheme of glucose metabolism and the respiratory chain in Gluconobacter oxydans DSM2343 PDC POLL POLI PMC9157768__F7 Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes TLR4 CX3CR1 SPIC BACH1 PMC8645845__F2 Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer VLDLR TUG1 POU3F3 ADM PMC11673387__F6 LTA causes mammary gland injury in dairy cows LTA PTGS2 SREBF2 PIGS TNF FASN PMC8233004__F5 Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development MVD MVK IPP PMC9658666__F2 Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance HGF DKK1 TNF IL1B PMC3924254__F7 A6 integrin is the upstream regulator of the IGF-1R signaling pathway that enables low levels of caspase-3 activation to signal lens epithelial cell differentiation initiation IGF1R SRC PMC8350499__F1 Acetylation in doxorubicin-induced cardiotoxicity IGF1R IGF2BP1 STAT2 MTOR SIRT3 STAT1 NLRP3 TINCR IGF1 SIRT1 STAT3 OPA1 BAX PMC6085989__F1 Proposed model of host signaling cascade in response to microbial signals to promote hematopoiesis STAT1 TLR4 NOD1 STAT2 IRF9 TRAF3 DAP IRF3 TYK2 MYD88 JAK1 PMC4767455__F1 Role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications TSC2 CUL4B HEL-S-11 XPC DDB2 DDB1 CUL4A PMC3678929__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway TSC2 BAD TSC1 IGF1 IGF2 GRB2 PTEN MTOR IRS1 ELL PMC10512581__F1 Hippo signaling pathway and therapeutic targets LATS1 LATS2 CDK6 ACTR2 PMC8660125__F1 Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma TLR8 TLR7 IRF7 TRAF6 IRF3 IRF-1 TLR3 CDHR3 PMC9613570__F2 Non-pharmacological interventions for vascular health and the role of the endothelium TRPV4 PIEZO1 KLF4 SRC KLF2 PMC3678929__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-1R) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) IGF1R IGF1 IGF2 PMC5423118__F8 Graphic summary DCTD TK1 PMC3092277__F1 Hippo signaling network in mammals AMOT NF2 LATS1 RASSF6 LATS2 PMC6901313__F11 Conceptual framework of BCL-xL expression during persistent LPS senescence induction NRAS BAX PMC7153214__F6 The mechanism STAT3 PMC10307880__F2 Viral-mimicry response induced by DNMTis TBK1 STAU1 IRF7 TES IRF3 TLR3 MAVS PMC5414155__F7 Overall impact of ethanol stress on C PIG59 MALL GIP PMC11642419__F2 PRV evades the TLR and RLR signaling pathways TBK1 TLR5 TLR7 TLR4 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS PMC7838829__F2 Going, Toll-like receptors in skin inflammation and inflammatory diseases CD14 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 LBP TIRAP TAB3 PMC11642419__F3 PRV evades the DNA-sensing signaling pathway TBK1 CGAS IRF3 UBE3C IFI16 PMC5597247__F1 Transcriptional regulation of glycolytic and mitochondrial metabolism MEIS1 MYC ENO1 HEL-S-87p HIF1A HEL-S-133P UCP2 STAT3 PMC6470739__F2 Antioxidant signaling pathway regulated by quercetin MAF EGR1 KEAP1 BAX PMC11642419__F4 PRV evades the IFNAR–JAK–STAT signaling pathway ISG15 EPO STAT2 ISG20 IRF9 TYK2 IFNAR2 TRIM26 MX1 PMC12213685__F12 HDH-SBH drug pair act on potential targets and mechanisms of action of PI3K/AKT signaling pathway BAD CDC37 PTEN RAC1 EIF4E MTOR IRS1 RHEB TSC2 TSC1 BCR MDM2 GRB2 SYK RBL2 CD19 PMC8966870__F2 ILC2s can contribute to tumour rejection or tumour growth IL33 CXCL8 CCL5 CXCL2 KLRG1 ARG1 PMC4325629__F1 Hedgehog signaling in cancer stem cells: a focus on hematological cancers HHIP PTCH2 KIF7 SUFU PTCH1 GLI3 CCND1 SMO PMC4325629__F2 Hedgehog signaling in cancer stem cells: a focus on hematological cancers PTCH1 CCND1 SMO PMC7838032__F3 The cyclin D–CDK4/6 complex ATM CDK2 GSK3B CDK4 ATR CDK6 PMC2818223__F2 GSK3 regulation of STATs, Smads, Beta-catenin, and NFAT LRP5 LRP6 STAT3 PMC8185945__F9A In Parkinson's patient-derived dopamine neurons, the triplication of Alpha-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition PLCG1 MAPK9 MAPK8 MAPK3 MAPK14 DRD2 MAP2K6 GNAI1 PDPK1 SRC MAPK1 JUN MAPKAPK2 FOS MAPK10 MAP2K2 MAP3K10 RAC1 MAP2K1 SLC18A2 RASGRF1 GRB2 MAPKAPK3 SOS1 BDNF SHC1 CDC42 VAV2 PMC9668345__F3 Alterations in the Salivary Proteome and N-Glycome of Sjögren’s Syndrome Patients RORC PML HGF PPP3CA NR3C1 VEGFA TNLG7A KRT2 STAT1 NFKBIA LGALS3BP COL1A2 OSM KRT10 PMC3393825__F1 Signaling the Mitochondrial Unfolded Protein Response NRF1 HTRA2 CLPP PMC6646234__F10 MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling HES5 THY1 BAX HES1 PMC2516358__F7 Time ordered sequential events control cellular decision of migration DHRS9 AKAP12 EGR1 HGF FOS PTGS2 PMC3925720__F1 miR-22 in tumorigenesis MYC PTEN PMC7381748__F2 TPL2 signaling CXCL1 NFATC1 MMP9 EGFR GSK3B COX2 MMP2 CXCR4 CD40 JUN IL1B BPI STAT3 PMC7779757__F1 WNT pathaway signaling ZNRF3 DAAM1 LEF1 APC PORCN GPR49 PMC3851544__F6 MT1G as a tumor suppressor in thyroid cancer cells through regulating the PI3K/Akt and Rb/E2F pathways.MT1G restoration inhibited phosphorylation of Akt, leading to inhibition of cell growth MT1G MDM2 PMC7751468__F6 Differentially expressed genes between normal mammary tissues and triple negative breast cancer tissues involved in PI3K/Akt signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes analysis MYB ME1 PI3 BAD BCR MDM2 SYK PTEN RAC1 PMC9664868__F1 Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library PPCS PPCDC PMC1082717__F1 The mTOR pathway and the potential intersection with LMP2A-activated PI3-kinase/Akt signaling MYC CCND1 EIF4E HIF1A MTOR PMC5896702__F2 Biomarkers of resistance to immunotherapy APC MDM2 CD80 JAK1 LAG3 PMC11929342__F5 Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties KEAP1 PMC12176563__F3 Multimodal regulation of cardiac metabolic flux and enzymatic hierarchy OGT BDH1 NR1C1 CD36 PMC12176563__F4 Metabolic-targeted therapeutic interventions for cardiac functional recovery HEL-S-62p DPP4 IMPACT GIP SIRT1 PMC8120183__F7 Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway BAD APAF1 PDK2 CDH2 BAX PMC7103699__F1 Schematic representation to highlight the possible mechanism of action by which adjuvants exert their adjuvanticity CGAS AIM2 TIRAP PMC4333386__F8 The functional interaction between RecQ helicases and the FA pathway BLM RAD51 MRE11A PMC11398426__F7 Regulation of STING expression by CBFB/RUNXIn basal conditions, CBFB acts as a rheostat to fine-tune cGAS-STING pathway activity TBK1 CGAS VHL IRF3 PMC7901659__F1 Prostaglandin-Endoperoxide Synthase 2 (PTGS2) in the Oviduct: Roles in Fertilization and Early Embryo Development COX2 COX1 PMC3144045__F1 Signal pathway activation by different surface PRRs CARD9 BCL10 IRAK1 IRAK2 SRC TRAF6 SYK HFE IRAK4 MYD88 MAL PMC3508273__F4 The role of tumor-associated macrophages (TAMs) during tumor angiogenesis IL10 FGF2 PMC5385204__F6 Genomic alterations in malignant melanoma CREB3L2 BRAF NGF GSK3B MYC MTOR HLA-B ASIP EP300 NGFR ATF4 MDM2 KITLG TFAP2A MC1R GNAS EZH2 AKT3 BOK PMC2783837__F2 TRAIL-R1/-R2 apoptotic signaling pathway FADD PMC6061042__F3 Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes ME1 SET FADS2 LPL PMC4482087__F7 Rewired upstream transcription subnetwork in regulating the downstream pentose phosphate pathway in biomass conversion in Y-50049 yeast strain versus the wild-type FBP1 NRG2 RFX1 NOM1 tal-1 PMC7693814__F5 Illustration describing inflammation and apoptosis mechanisms in SARS-CoV-2 infection, suggesting similarity with those in Parkinson’s disease under oxidative stress STAT1 PARP14 TYK2 ACE2 FADD TMPRSS2 STAT3 PMC5167405__F8 Non-Canonical Role of IKKA in the Regulation of STAT1 Phosphorylation in Antiviral Signaling TBK1 STAT1 IRF3 TYK2 IL6 JAK1 MAVS PMC7554875__F1 NFKB and MAPK pathways SP2 IRAK1 IRAK4 MYD88 TNF PMC4066980__F4 Model for Id1 regulation of melanocyte growth and melanoma development NOP16 BRAF ID1 PMC5791865__F1 Impact of MK2- and IKK-dependent phosphorylation on RIPK1 function RIPK1 CASP8 FADD PMC7241659__F1 Cellular metabolism during T cells activation MYC HIF1A MTOR CD36 PMC8363725__F6 The biosynthesis of the nemamides HEL-S-62p PCP2 PCP4 PMC12150591__F2 Oxidative stress plays a dual role in CRC development APC GSK3B CCND1 PMC6469615__F2 Proposed metabolic pathway for shea butter biosynthesis adapted from Argout et al GPAT4 PC LPA PMC4482087__F6 Rewired transcription network regulating metabolic pathways for tolerant industrial yeast Saccharomyces cerevisiae NRRL Y-50049 OAF NRG2 GAL PMC12150591__F3 Differential regulation of oxidative stress and cell death by wild-type and mutant p53 MDM2 NOX4 MTOR UCP2 PMC12150591__F4 Oncogenic roles of KRAS and BRAF mutations in CRC development, malignant transformation, and metastasis BRAF GCLC PDPK1 PMC4610744__F1 Genes and pathways identified from GWAS and/or studies of monogenic allergy-related diseases LRRC32 TGFBR1 DOCK8 MYC TGFBR2 PLCG2 WAS IL6R FOXP3 DSG1 FOXA1 IL1RL1 FLG IL2 LPP KLF13 OVOL1 GATA3 IL2RB PGM3 IL13 PTGER4 TLR1 TSLP TLR10 CDHR3 BCL6 NFATC2 IKZF4 CDSN SPINK5 IL33 RORA STAT3 PMC7958998__F2 From genetics to pharmacological treatment.Notes: Bone morphogenetic protein receptor II, BMPR-II; BMP-responsive element, BRE; Caveolin-1, CAV1; 12-kDa FK506-binding protein, FKBP12 BMPR2 SMAD4 KCNK3 SMAD1 DKFZp781O1323 PMC6201690__F1 Overview scheme of the PD risk factor genes and the molecular pathway where they are involved VPS35 SNCA LRRK2 FBXO7 HEL-S-130P ALAS1 PINK1 HLA-DQA1 KAT8 TMEM175 SLC17A5 MCCC1 BST1 SMPD1 SCARB2 COQ7 PMC10152798__F5 HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway WNT4 PMC3464266__F3 Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data OR10C1 OR11A1 NMUR1 OR13A1 OR13C3 F2RL3 CHRNB3 LPAR1 CHRM5 CCKBR EDNRA NEUROG3 GZMA OR1C1 OPRK1 MAPK1 OR14A16 OR10G3 OR10P1 MYLK3 GABRG1 OR13C9 AKT3 OR13F1 PMC4390253__F1 Construction of the Golgi/endosome network (GEN) and of the IR subnetwork (IRGEN) APOA4 HEL2 PLVAP PRKAA1 PRKCSH FKBP2 CLU KIF5A INSR AK2 UBC ACACB ANXA2 GCS1 CRP LPL CIC HEL-S-70p TPMT CAD PHB2 CTH ARCN1 GRB14 LAMP2 PIGR KRT18 HEL-S-162eP APOB GNAT1 HP HEL-S-273 LNPEP HEL107 PMC8698340__F2 Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature PAK1 TLR4 GRB2 TRAF6 MYD88 TIRAP PMC7940388__F6 Signaling pathway mediated by CBD in SH-SY5Y cells ULK1 ULK2 MTOR TRPV1 PMC3817717__F2 Ingenuity Pathway Analysis (Ingenuity Systems, Inc., Redwood City, CA) of endothelial gene expression IKBKE FBLN2 TPM1 ARHGAP8 SERTAD1 HEL-S-99n MYC TPM3 TMOD2 AP1B1 TRAF6 SERPINB6 WAS DNAJC10 HIF1A DHPS TFDP1 XBP1 ARHGAP1 PLAT ATM SP1 ADM JUN SEC61A1 STAR EPHA4 TP53BP2 SERPINI1 THAP7 DBN1 NAB2 PLG PACRG ATP6V0C FGF2 ARHA CEBPA LTBP1 BIRC2 SIRPA ERAP1 ERN1 EPHA2 CDK9 SMAD1 PMC8855225__F1 Gli Phosphorylation Code in Hedgehog Signal Transduction KIF7 PCK1 SUFU GPR161 SMO ADRBK1 CP PMC6660363__F2 Serum Proteomics Based Discovery Of Predictive Biomarkers Of Response To Androgen Deprivation Therapy In Advanced Prostate Cancer APOA4 AFP RPN2 HSD17B7 LPA PIGR LEMD3 MUC5B MXD4 HP AHSG HBB ITIH3 COMP TGFB1 KRT1 STAT3 PMC5660951__F7 Suggested mechanism of EtSCT action in CCl4-induced hepatic injury MMP2 SMAD2 MMP9 BAX PMC9127077__F1 C-Type Lectin Receptor Signaling in the Intestinal Microbiota-Inflammation-Cancer Axis CARD9 SAP130 AHR SYK CXCL2 RAF1 STAT3 PMC8585084__F3 Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System ULK1 USP15 ATG12 ATG3 TRAF6 ATG10 SYVN1 DKFZp686F0183 NEDD4 TRIM65 NOTCH1 ATG14 SIRT1 TRIM37 PMC4115639__F4 Cartoon depicts IL-15 mediated activation of the PI3K/ERK1/2 and JAK1/STAT3 pathways IL15RA JAK1 IL2RB STAT3 PMC3681701__F9 Sources of sphingolipids for the parasite RAB14 DES RAB43 RAB30 SMS PMC4226052__F6 Up-regulation of the type I IFN canonical pathway by IFNB treatment STAT1 IFIT3 STAT2 IRF9 TYK2 JAK1 PSMB8 IFIT1 PMC8463267__F10 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway CD44 CDH2 PMC3822007__F1 New developments in the Induction and Antiviral Effectors of Type I Interferon TBK1 TRAF3 IRF3 PMC6801420__F5 Pathway signaling network generated from the genes located within the top 100 most differentially methylated CpG islands ALK ARHGAP32 ATF2 GSK3B PAK4 SHC3 MLLT1 TTBK1 TAF12 TEAD2 PRKCA FRS2 SRC SMO RNF111 PTPN6 SKI JUN PCM1 KLF16 YAP1 VAV1 APC CER1 TNKS DTNB IRS1 EIF4G1 TNKS2 CBL DYRK1A NTF4 EP300 GAB2 STK11 DGKZ ARC SH2B1 GNAS FLT3 SHC1 PMC3925679__F2 Bile Acid Receptors in Non-alcoholic Fatty Liver Disease FGF21 ANGPTL3 PCSK9 VLDLR LPL LDLR FGF19 PDK4 TG NR1C1 PMC7670427__F3 EIF2 pathway overlay with the experimental data, AD detection and molecules activation prediction (MAP) EIF2A CCND1 NOX4 ATF3 PMC8015775__F11 Proposed model for a role of BANK1 in tolerant patients BCR BANK1 TRAF6 SYK BLK DIABLO FADD PMC7946832__F1 Complement cascade and key canonical and non-canonical activities CD46 MTOR PMC6517507__F1 Model suggesting the relationships between Th17, Th1* and cTh1 populations and their potential roles in post-vaccination immunity, LTBI and active TB CXCR3 IL16 CCR6 IL1B PMC6008051__F5 Network interactions of transcription factors predicted to be upstream of differentially expressed skeletal muscle genes SMARCA4 MYLK2 VEGFA TNNC2 MSTN RB1 HIF1A MYOD1 PMC4966488__F1 Viral oncolysis dependent on RNA-activated protein kinase (PKR) inactivation EIF2A FADD STAT3 PMC6356359__F6 Proposed epigenetic model of colonic inflammation and carcinogenesis associated with long-term exposure to a diet high in n-6 fatty acids (n-6HFD) APC CCND1 PMC9629042__F2 Ultrasensitive chemiluminescent neuraminidase probe for rapid screening and identification of small-molecules with antiviral activity against influenza A virus in mammalian cells MAX POR PMC3631177__F2 Expression of Glyceraldehyde-3-Phosphate Dehydrogenase Associated Cell Cycle (GACC) Genes Correlates with Cancer Stage and Poor Survival in Patients with Solid Tumors FBP1 HEL-S-87p PMC8960167__F1 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy CYLD APAF1 TNF MLKL GSDMD BAX DFNA5 PMC8960167__F2 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy GPX4 LPCAT3 FACL4 SLC7A11 NFE2L2 AIFM1 ALOX15 PARP1 PMC5964334__F6 Proposed model of an energy balance-responsive network associated with DNMT1 regulation, DNA methylation and transcriptional regulation of ERA and ERB EGF IGF1R TLR9 IGF1 EGFR TNF IRS1 IL1B STAT3 PMC4002811__F2 Peli1 mediates IKK activation by the TRIF-dependent TLR pathway TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 PELI3 MYD88 PELI1 TLR3 PMC3268129__F1 Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins TTL RET GRAP PMC7869004__F6 Drug target prediction and repurposing“Waterdrop” diagrams showing drug-target PPM2C TES SNAP25 MTOR GLS PMC8664259__F7 Role of TAF7 in linking transcription and translation TAF1 TAF7 TEF BRD4 PMC5474130__F2 Oxysterols in human cancer ABCA1 OSBP ABCB1 PMC6645245__F11 Schematic diagram representing possible antifungal mechanism (a–e) of CIN and EUG in C ERG IDI1 ASPA PMC9329358__F1 Molecular mechanism of pyroptosis HMGB1 GZMA TNF GSDMC GSDMB GSDMD DFNA5 PMC4689482__F2 ARID1A mutation and anticancer agents on the PI3K/AKT pathway BRAF PTEN MTOR ARID1A PMC3494084__F4 Baculovirus infection impact on host cell metabolism CS CIT MAL PMC5902007__F1 The gut microbiota in health and MS FOXP3 PMC11638311__F4 Metabolic pathway of sphingolipids SPTLC1 SGPP1 SPHK2 SPTSSA CERS3 LASS1 SPTLC2 CERS5 DEGS1 CERK DEGS2 CERS2 SGPP2 PMC11531110__F8 Metabolic pathway analysis and metabolite-protein interaction networks in broiler chickens challenged with CP and its different toxin combinations IMPACT HEL-S-53e PMC11531110__F9 Integrated metabolic pathway network analysis in NE-affected jejunal tissues P4HA2 CS PC ARG2 ALDH18A1 NOS2 PMC10136970__F3 Pan-pathway inhibition EGF EGFR GRB2 CDK4 CDK6 PMC6678315__F2 Activation of c-Rel signaling by the canonical NFKB pathway in B cells BTK BCL10 BCR CD40 PLCG2 PMC8257365__F1 Dietary Antioxidants in p53-Mediated Cancer Chemoprevention and Tumor Suppression PERP BAX PMC5838194__F3 Gene ontology enrichment of relate 16 key genes to the PPI network of NAFLD rat after fat diet feeding is presented ACACA ALB ACACB INS SRC MAPK1 DECR1 ACLY TNF PMC10419059__F3 Wnt/Beta-catenin signalling pathway LRP4 APC LRP5 LRP6 SFRP1 DKK1 DKK2 PMC10419059__F2 Insulin and IGF-1 signalling pathway IGF1R IGF1 GSK3B PMC7711884__F1 Graphic scheme of the genes involved in the adsorption, distribution, metabolism and excretion (ADME) of fluoropyrimidines ABCC3 CDA DPYD CES2 CES1 UCK2 DPYS UPP2 UMPS TYMP UCK1 SLC29A1 CYP2A6 TK1 RRM1 SLC22A7 RRM2 TYMS ABCC5 ABCG2 PMC3179949__F6 A schematic representation showing 17Beta-estradiol inhibition of uPA and MMP-9 expression, and cell motility via suppression of JNK1/2 pathway in human LoVo colon cancer cells TIMP1 NMB TIMP3 PMC6266080__F4 LPL pathway and associated proteins SEL1L ANGPTL3 ANGPTL4 LPL LMF1 GPIHBP1 PMC9511810__F2 Base excision repair accessory factors in senescence avoidance and resistance to treatments FEN1 NF1 COX2 KEAP1 Nbla10317 SATB1 NOX4 CUX2 PTEN PMC4370285__F8 Schematic model of EGFR stabilization by cigarette smoke EGF EGFR GRB2 PMC8174805__F1 Disparate roles of retinoid acid signaling molecules in kidney disease LRAT FABP5 PMC4381776__F1 One-carbon metabolism in the cytoplasm and nucleus MTR DHFR TK1 PMC4889059__F2 Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype PC MTOR PMC8961234__F4 Unraveling the regulation of sugar beet pulp utilization in the industrially relevant fungus Aspergillus niger ABRA PMC10523725__F7 Gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis GPX4 SLC7A11 SLC3A2 PMC2577794__F1 Uncovering cryptic genetic variation in C EGF EGFR GRB2 ADAM10 PMC6098952__F1 Schematic representation for the possible interaction of viral oncogene proteins with various levels of Wnt/Beta-catenin cell signaling cascade SIAH1 APC GSK3B MYC LRP5 CCND1 SRC LRP6 PMC5901897__F2 MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy PML FOXO3A FOS HIF1A STAT3 PMC5541270__F8 Proposed mechanistic scheme of MUC13 regulating NFKB activation, related to , , and MUC13 TRADD ATM TRAF6 PARP1 PMC12119701__F8 Possible mechanism underlying KCTD1-enhanced HCC progression KCTD1 MTOR PMC6082822__F1 Autoimmune Responses in Severe Asthma IL16 MPO EPX APC CCL21 CCL17 ELL PMC8375270__F1 When Viruses Cross Developmental Pathways DHH IHH SUFU SHH SMO PMC4946912__F7 Network of transcriptional regulation and ligand receptor signaling CXCL1 MSI1 CHAF1B CREB1 HEXIM1 HOXD13 RNF32 ASB13 ELAVL1 TGOLN2 ZFP36 GNL2 TMEFF2 BASH PHF20 RGS16 AF1Q IRF-1 BARX1 CD14 GDE1 MGP EGR1 ZFP3 IRF2BPL BARD1 GADD45A CHAC1 TMEM33 RHOD EGR2 ENO2 BDNF GALNT1 STAT3 PMC5226473__F1 CDK4/6 inhibition: the late harvest cycle begins TSC2 EGFR CDK4 MTOR RHEB PMC8375270__F2 When Viruses Cross Developmental Pathways NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC10237620__F1 MTOR signaling pathway in cardiac aging TSC2 PINK1 ULK1 TSC1 RHO MTOR DEPTOR SGK1 MLST8 PMC4007103__F2 Biogenesis of Drosophila small regulatory RNAs AGO1 AGO2 DROSHA PMC128142__F1 Proposed biosynthetic pathway of GPI in the ER of P PIGM GIP PIGA PMC7713543__F2 SARS-CoV-2 Replication and Interaction with Host Cells(A) Simplified schematic of the viral replication cycle TLR7 ACE2 TLR3 MAVS TMPRSS2 PMC8375270__F5 When Viruses Cross Developmental Pathways IHH HES3 HES4 DKK1 FBXW7 HES1 HES5 DLL4 EVC FZD7 SHH SMO HES2 PMC4147239__F1 MTOR signaling pathway TSC2 TSC1 PTEN EIF4E IRS1 RHEB PMC9436908__F2 Modulatory effect of high salt on immune cells and related diseases NLRP3 NLRC4 NFAT5 TNF MTOR ARG1 IRF4 PMC11979251__F2 Immunogenic cell death (ICD) induced by epigenetic modifiers of DNA methyltransferase, histone deacetylase and proteasome inhibitors HMGB1 ANXA1 HDAC3 CXCL10 HEL-S-99n TUSC2 XBP1 PMC5061805__F1 Fast action antidepressants activate mTOR EEF2K MTOR BDNF PMC11979251__F3 Molecular mechanisms of immunogenic cell death (ICD) related to reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress ATF4 SP1 PMC5061805__F2 Mechanisms involved in the delay of therapeutic response to classic antidepressants in MDD patients EEF2K MTOR BDNF PMC11979251__F6 Crosstalk between immunogenic cell death (ICD) and different intracellular signaling pathways of nuclear factor kappa-B (NFKB), stimulator of interferon genes (STING), and mitogen-activated protein kinase (MAPK) TBK1 HMGB1 HEL-S-99n IRF3 PMC4856820__F3 Schematic picture demonstrating the myogenesis pathway and the myogenic regulatory genes (highlight in red color) identified in beltfish muscle transcriptome MYF5 PAX7 PAX3 PMC3755473__F1 Plasma Cells For Hire: Prior Experience Required BACH2 MTOR PMC9363660__F1 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation BCR PREB HEL-S-92n TNF IFNG PMC1316260__F6 Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway PLCG1 EGF SHE PMC7803547__F2 CD8+ T-cell metabolism in COVID-19 KEAP1 APC CD80 MTOR IL1B PMC4696838__F2 MSCs reduce a central profibrotic factor, TGFB1, using STC1 in bleomycin-induced pulmonary fibrosis PI3 BLM MTOR UCP2 PMC7666630__F4 Constructed ceRNA networks based on the selected vital genes related to the MAPK signaling pathway: (a) the circRNA-miRNA-mRNA network and (b) lncRNA-miRNA-mRNA network HEL-S-102 GADD45B DUSP5 DUSP10 GADD45G FOS DUSP2 BDNF DUSP8 JUN PMC3658475__F2 P53/MDM2 regulation ATM MDM2 XPC ATR BAX PMC7784881__F1 CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels IL10 BCR CD5 LYN SYK PLCG2 MTOR PMC2846071__F1 Prevention trumps treatment of antibody-mediated transplant rejection HEL-S-62p BCR CD40 PMC5642988__F1 Hippo pathway in intestinal regeneration and disease AMOT YAP1 LATS1 RHO LATS2 PMC4174460__F1 Seven FDA-approved agents for the treatment of kidney cancer targeting the von Hippel–Lindau (VHL) tumour suppressor pathway EGFR VHL MTOR TGFA PMC5642988__F4 Hippo pathway in intestinal regeneration and disease YAP1 EGFR PMC2276649__F8 GSK-3B Targets Cdc25A for Ubiquitin-Mediated Proteolysis and GSK-3B Inactivation Correlates with Cdc25A Overproduction in Human Cancers ATM GSK3B ATR PMC11975862__F7 Active ingredient–shared target–pathway network analysis REN SHBG MDM2 PMC5642988__F5 Hippo pathway in intestinal regeneration and disease YAP1 LATS1 LATS2 PMC3565315__F1 Overview of the Hedgehog signaling pathway: a simplified model for Hh signaling in mammalian cells KIF7 SUFU SMO PMC5642988__F2 The Hippo pathway in intestinal regeneration and disease HEL70 EGFR CCNE1 PMC5638134__F6 Chloroformate Derivatization for Tracing the Fate of Amino Acids in Cells and Tissues by Multiple Stable Isotope Resolved Metabolomics (mSIRM) PSAT1 SHMT1 GLDC MTHFD2 PHGDH PMC5642988__F6 Hippo pathway in intestinal regeneration and disease YAP1 LATS1 MOB1A LATS2 PMC3565315__F2 Overview about currently tested Hedgehog pathway inhibitors and their mode of action DHH IHH KIF7 SUFU SHH SMO PMC8961445__F2 Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? TLR4 TLR9 BCR SYK MYD88 HIF1A STAT3 PMC8433626__F5 Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine DPM1 DPM2 DPM3 PMC8611677__F5 Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder P2RY11 P2RY1 RBMS1 NMUR1 SOX2 GPR68 ERG S1PR3 CCR1 SIX4 PIK3R5 SALL3 PHC2 NPY5R GALR2 DYNLT1 SRC NPY4R ADGRE5 WNT2B HCRTR2 HILPDA PMC10466072__F9 Schematic diagram RASSF1 CDK4 LATS1 PTEN LATS2 CDK6 PMC6826584__F5 Notch signaling pathway by ubiqutination upon binding of Jagged/Delta (JAG/DLL) ligands to the Notch receptor (N1); the endocytic system is activated in the ligand-bearing cell EGF MAML1 NUMB MIB1 DLL3 LNX2 FBXW7 ADAM17 NEDD4 HES1 RNF8 MDM2 NOTCH1 ADAM10 MIB2 ITCH PMC7150840__F1 Simplified scheme of the Wnt/Beta-catenin signaling pathway APC SOST GSK3B LRP5 LRP6 PMC5552414__F7 Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma TWIST1 PTEN STAT3 PMC7150840__F2 FGF23/Klotho interactions with the Wnt/Beta-catenin pathway in the bone, kidney, and heart FGF23 FGFR1 PMC2843459__F11 Schematic diagram illustrating the proposed signaling pathway involved in LTA-induced cPLA2/COX-2–dependent airway inflammation LTA RAC1 MYD88 PMC9363660__F3 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation TNF IFNG PMC6826584__F3 Wnt signaling pathway and its regulation by ubiquitination The canonical Wnt signaling pathway is triggered by Wnt ligand binding to the complex of its receptor, Frizzled, and co-receptors LRP5/6 ZNRF3 RNF43 APC LRP5 MYC SKP1 RNF146 FGF18 GPR49 SMURF1 SIAH1 SMURF2 CCND1 SIAH2 ITCH PMC6826584__F4 TGFB signaling pathway and its regulation by ubiqutination TGFB released from the LTBP1 complex binds to TGFB receptor II (TGFBRII) and initiates transphosphorylation and activation of the associated TGFB receptor I (TGFBRI) MYCBP2 SMAD2 SMAD4 MIXL1 WWP1 SMURF1 LTBP1 FAF1 SMURF2 HGS GSC SKP2 ITCH PMC4145234__F1 Regulatory networks of miRNAs and PI3K/AKT pathway in controlling EMT and cancer stemness in human tumors including endometrial cancer TWIST1 PTEN EZH2 MTOR PMC8863680__F2 Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations TBK1 STAT2 IRF9 IRF3 TYK2 JAK1 MAVS PMC7272579__F5 KEGG database pathway hsa05200: pathways in cancer CDK2 POLK MDM2 CDK4 CDK6 BAX PMC9022632__F2 Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells HLA-E SYK TNF PMC6298254__F3 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway S1PR2 TRADD AMOT TROAP TRAF3 OPTN PRIM1 RAB11B STAT1 CYLD NDNF FZD7 RAB9A ULBP3 MOXD1 MINDY3 GDI1 UMAD1 CASP8 RNF115 OFD1 CCDC112 HEL-S-166mP CEP135 CCDC14 MLF1 MKRN2 GOLGA3 TNF LNX2 TRIM25 MAP3K7IP1 YOD1 TXLNA TRAF5 TRAF1 AMOTL1 SHARPIN DHFR CETN3 NCS1 TRAF2 FADD ACTG1 MAVS TRAF4 PMC3865046__F1 Proteasome-dependent degradation of replisome components regulates faithful DNA replication MRC1 TIMELESS CDS1 ATRIP SKP1 ATR RBX1 PCNA PMC12066772__F16 The mechanism by which Iso inhibits RANKL-induced osteoclastogenesis CTSK NFATC1 MMP9 TRAF6 PMC8775422__F4 Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside APC LRP5 LRP6 PMC4766428__F2 Bacterial cellulose synthesis mechanism of facultative anaerobe Enterobacter sp. FY-07 PDC OTP HEL-S-162eP PMC6298254__F1 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway RNF11 TRADD CYLD SHARPIN TNF MAP3K7IP1 OTULIN TRAF2 CASP8 FADD ITCH PMC10518103__F9 DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress HSP90AB1 DSCC1 STAT3 PMC4979363__F6 Proposed mechanism of Hb (and its oxidized species)-induced toxicity: Hb undergoes oxidation to higher oxidation states, such as HbFe3+ and HbFe4+ TLR4 HP F2 PMC2762009__F1 The Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders NACA HRAS PSD PMC8468657__F3 Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective EGF EGFR PTEN MTOR PMC2849853__F5 Regulation of the Hypothalamic Thyrotropin Releasing Hormone (TRH) Neuron by Neuronal and Peripheral Inputs NPY AgRP MC4R ARC PMC3788099__F7 Association between Inflammatory Infiltrates and Isolated Monosomy 22/del(22q) in Meningiomas CD58 FCGR1A FCGR2A MSR1 WAS MYD88 HIF1A CD74 HLA-DMA CCR1 PRKCA TLR7 SEMA4D IL17RA IL10RA IL1B CD14 TLR5 IRF8 HLA-DOB APC CD44 CYBB HLA-DRB1 CD69 TYROBP PTPRC FCGR3A CD59 HLA-DQA1 VCAM1 GAB2 LYN BCL2 CD40 IL11RA CD93 HLA-DMB IGF2R PMC4747886__F4 Molecular mechanisms of survivin in tumorigenesis SMAD2 MDM2 SMAD4 CDK4 STAT3 PMC7522266__F2 Bifidobacterium longum subsp HEL107 PMC9524955__F7 Study on the mechanism of warming yang and reducing turbidity decoction in the treatment of diabetic kidney disease based on network pharmacology PIN1 EGR1 SMAD2 SMAD4 FOXO1 TF SELE PMC7843730__F2 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome PIK3R1 CD9 PSCA hCG_1641087 MAPK12 LY6G6D LYPD3 UBE3A AREG ERBB3 APC GRIA3 PTPN13 CTNNA1 ACP6 LRFN2 LYPD2 CACNG2 LYPD6B GRIA4 TGFA CDC42 EGFR AKAP5 MYO6 DLGAP1 CAMK2D LY6K IZUMO3 IZUMO2 IZUMO4 CAMK2G SPACA1 ARHA RAC1 ATAD3C ADAM18 GRIK2 SPACA4 LY6H TEX101 LYPD4 ARHGAP15 TMEM121 LY6G6C PLEKHA2 LRFN4 ERBB2 LRFN1 TANC1 PIK3CA CAMK2A PMC7843730__F5 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome ChAT CSTA LYST ADA WAS POR GRAP BOK PMC8258133__F2 Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells PRDM16 EBP MSC PMC3664143__F1 A Novel High-Throughput 1536-well Notch1 Gamma-Secretase AlphaLISA Assay MBP ADAM10 ADAM17 PMC8279913__F2 Current therapeutics against HCV TRAF6 TLR3 MAVS PMC9019414__F4 Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer EGF BAD MMD ACACA PTGS2 EGFR MAPK3 VEGFA IL6 ACHE TNF POR HEL-S-130P HMGCR PLAT AHR PPARG JUN IL1B SELE BAX PMC8396838__F5 Comparative Transcriptome Analysis Reveals bmo-miR-6497-3p Regulate Circadian Clock Genes during the Embryonic Diapause Induction Process in Bivoltine Silkworm CRY1 CRY2 DBT PMC6590462__F6 Japanese encephalitis virus (JEV) intracellular effect mechanism PAK4 XBP1 PMC7880553__F2 Figure 2.Metabolites in early adulthood are associated with the cardiovascular phenome and identify pathways central to CVD development HEL-S-62p CS PC PMC4373423__F10 Suggested model for RF effects and interactions in various mouse tissues TNF NR1C1 SIRT1 PMC1195968__F1 RSV binding and triggering of cellular responses TLR4 IRF3 MYD88 PMC6874141__F1 Ras signaling pathways RARA EGFR PMC9112062__F7 Endothelial AMPKA1/PRKAA1 exacerbates inflammation in HFD‐fed mice EP300 PRKAA1 ACLY PMC11825097__F8 LIPG regulates goat intramuscular preadipocyte lipid deposition through the PPARA signaling pathway LIPG TG FASN PMC7094317__F2 Cell polarity pathways are targeted by diverse human viruses.Interplay between the Scribble (SCRIB), PAR, and Crumbs (CRB) complexes is central to the control of cell polarity PATJ APC SCRIB HBZ FAT4 CDC42 PMC7763974__F4 Apoptosis induced by high levels of NO is mediated via activation of the extrinsic apoptosis pathway which involves the TNFR and Fas/Death Receptors TRADD TRAF6 TRAF2 FADD BAX PMC2774076__F7 Current working model of the signaling pathway components (shaded areas) that are differentially regulated in C57 and CD-1 pup brain tissues and cultured NSCs under normoxic and hypoxic (Hx) conditions CXCR4 HIF1A MTOR BDNF STAT3 PMC9230939__F2 Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia AHR EGFR PMC6485344__F1 The Krebs cycle CS FH ACO2 OGDH PMC5066299__F35 S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway KEAP1 MMP9 IL1B TF PMC6020056__F1 Complement cascades HEL-S-62p PMC3269021__F8 Interaction of TOR pathway members for the regulation of phagocytosis TSC2 PDK2 PTEN RHEB PMC4362528__F8 Human splicing code reveals new insights into the genetic determinants of disease NDRG2 LARS2 PPP5C AP3B2 ARHGAP32 LHX1 PCNT RPS8 NISCH RPL19 PRPF19 CDC45 CDHR2 AGO1 EIF3F PSMC6 KCNH3 COL13A1 AK8 DMBT1 CEP250 RAB3GAP1 CSPG4 PMC3143377__F2 Molecular Targeted Approaches in Mantle Cell lymphoma BAD GSK3B PTEN PMC6042708__F14 Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells PDHA1 PFKL PGAM1 PMC9488512__F3 Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis FGF10 SHH FGF9 PMC3143377__F3 Molecular Targeted Approaches in Mantle Cell lymphoma BTK BASH MTOR PMC3195192__F2 VEGF-VEGFR signaling in lymphangiogenesis VEGFC VEGFD VEGFA PMC4151823__F9 WWOX At The Crossroads Of Cancer, Metabolic Syndrome Related Traits And CNS Pathologies RUNX2 SMURF2 SMAD4 SMURF1 WWOX PMC8249521__F3 Introducing the novel Cytoscape app TimeNexus to analyze time-series data using temporal MultiLayer Networks (tMLNs) CDC20 POLE POLA2 SCT RAD17 HEL-S-92n SMC4 COCH PMC5352450__F2 Next generation sequencing and its applications in HPVassociated cancers KEAP1 EGFR TP63 NFE2L2 TRAF3 MYC FGFR3 PTEN RB1 CDKN2A HLA-B CDK6 HLA-A BIRC2 FGFR1 ERBB2 B2M CASP8 FADD LTBR PMC7063521__F1 Positive and negative regulators of hepcidin synthesis ERFE BMP6 BMP2 SMAD4 TMPRSS6 HFE TFR2 STAT3 PMC4811695__F1 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects NOTCH2 NOTCH4 GSK3B PTEN MTOR DEPTOR NOTCH3 RHEB MLST8 TSC2 TTI1 NOTCH1 GRB10 PMC6927459__F12 The impact of PSC and tumor cells on immune cells in the pancreatic cancer stroma SPARC TLR9 MICB SMAD2 POSTN TGFBR1 SMAD4 MTOR ADAM17 IFNG COX2 MICA IL2 IL4 HEL-S-133P IL10 CCL11 IL13 CTLA4 TIGIT IL6 SERPINE2 BCL2 ADAM10 CD80 CCL18 CXCL12 TGFA CCL22 PCNA STAT3 PMC8648391__F1 Potential synthetic lethal strategy with PARP inhibitors: perspective on ‘Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP’ MDM2 SNRPA1 PMC2757632__F1 O-GlcNAc cycling: Implications for Neurodegenerative disorders TRAK1 OGA OGT NUP62 PMC533963__F11 Model illustrating the signaling pathway through which Brk participates in EGF-induced cell migration and invasion EGF EGFR RAC1 CRKL PMC6591840__F5 Potential mechanisms underlying EOC chemoresistance and the sensitizing effect of PI3K inhibition CS HEL-S-53e CDH2 MTOR PMC4811695__F3 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects FGF21 TTI1 RICTOR UCP1 C6 MTOR FOXC2 DEPTOR PMC6927459__F10 The crosstalk between PSC and pancreatic cancer cells EGF IGF1R CD44 ANXA6 HIF1A SERPINE2 HEL-S-32 SLC1A2 THBS1 ABCA1 TGFB1 GLS CD36 PMC9466598__F1 The hedgehog signaling pathway in rheumatic diseases: An overview ENPP1 SUFU SMO TRPM7 PMC7232513__F2 Interplay between virus-induced cellular aggregates and inclusions AGO2 ATF4 EIF2A ELF4 PMC9634253__F2 Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer PLK3 ATM MTOR STAT3 PMC6223216__F1 Wnt signalling pathways APC LRP5 LRP6 RYK RHO PMC7383044__F1 Activated c-Mpl dimer leads to activation of multiple signaling pathways which promote proliferation and platelet production GRB2 MPL PMC6234444__F1 Induction of oxidative stress by a virus infection and genome replication MAF KEAP1 NQO1 PMC2784899__F7 Model to account for responsiveness to cAMP level in activation but not inactivation of eumelanin synthesis MGRN1 ASIP MC1R PMC11669278__F7 Interaction network among the key genes, enzymes, pathways, and metabolites ChAT PIG59 TPH1 GPT AOC2 MAOA NAGS GFPT1 AARS2 HEL-S-5 GOT2 PLD2 CHKA GPT2 ASNS PHOSPHO1 AGXT CHKB BCHE CAD AASDHPPT NADSYN1 AGXT2 KLK1 PMC9259182__F6 Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach CASP3 EDN1 VCAM1 TF SELE PMC5746547__F1 PFKFB3-driven glycolysis and the central role of FAO via CPT1a function in ECs (a) Schematic of PFKFB3 as a key regulator of the glycolytic activity in ECs and the angiogenic switch F2 PROX1 PMC8588021__F3 Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders KEAP1 GCLC IL1B NQO1 PMC5833380__F3 ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells HEL-S-89n GCLM ENO1 PFKL HEL-S-68p HEL-S-162eP F2 HEL-S-304 ENO2 HEL107 HEL-S-133P HK2 GLS PMC4917857__F3 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis SQLE DHCR7 EBP FDFT1 SC5D DHCR24 CYP11A1 HSD17B7 TM7SF2 HMGCR PMC2820725__F4 Redox signaling responses in DCs and T cells during T cell activation LCK GRB2 CD80 LAT PMC4917857__F7 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis CYP27A1 CYP46A1 CYP11A1 HSD17B7 CYP7A1 PMC4336945__F3 Roles of Microphthalmia Transcription Factor and pigmentation in melanoma POMC DCT TYRP1 PMC3558493__F8 ErbB2-Dependent Chemotaxis Requires Microtubule Capture and Stabilization Coordinated by Distinct Signaling Pathways PAK1 ERBB2 APC ARHA RAC1 CDC42 PMC2888582__F6 Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction HEL-S-62p CD9 HEL-S-1 ACTA2 EGFR SMAD2 POSTN ALOX12 HEL-S-99n TPM3 CFL2 TFRC PNN HIF1A ITGA2 JUP MYL12A CCND1 ACTN4 VANGL1 ACR GNG5 ANXA1 PROX2 ARHA VDAC3 RAB21 HSPG2 VCAM1 VTN HEL-S-273 GNPNAT1 HEL113 ITGAV APOH EPHA2 LRPAP1 ACTR3 GNB1 BCAP31 IGF2R PMC9257096__F15 KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway CDK2 CDH2 MTOR KIFC3 PMC5520463__F1 The serine synthesis pathway (SSP) diverges from glycolysis utilising the intermediate 3P-glycerate, which is converted by PHGDH, PSAT-1, and PSPH into serine and then glycine PSAT1 PSPH PHGDH PMC6168630__F1 PI3KD activation in B- and T-cells during class-switch recombination BCR BASH AID ZAP70 PTEN UNG RAG2 LAT PMC9562258__F1 BRAF Inhibitors in Non-Small Cell Lung Cancer BRAF GRB2 ARAF PMC8139249__F1 Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment? SOX2 MSX2 HOXA2 SMAD1 PMC2875624__F1 Alterations in transforming growth factor beta signaling cause changes in chondrocyte differentiation and osteoarthritis development RUNX2 SMAD2 SMURF2 SMAD6 SMURF1 SMAD1 DKFZp781O1323 PMC4552299__F2 Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells SLC43A2 HEL-S-62p NFAM1 OLFML2B RAB37 NLRC4 GNLY NLRP1 CD48 KRT23 TNF PROK2 AQP9 STEAP4 CD80 SASH3 CST7 PMC4479532__F3 Activation of a B-cell and its regulation by miR-155 BCR LYN SYK PMC4190552__F1 Roles of leukotrienes and acetylation in the expression of pro-inflammatory mediators through the NFKB pathway LTA KPG_011 LTB RELB PMC2891887__F2 Lymphangiogenesis and Lymphatic Metastasis in Breast Cancer VEGFC CXCR4 CCL21 CCR7 VEGFA PMC4702319__F1 CagA mediates dysregulation of the Wnt/Beta-catenin signaling pathway APC GSK3B TEF LRP6 PMC3526371__F1 NFKB activation in pathogenesis and therapy of cancer RELA EGFR LTB TRAF6 PTEN MYD88 TRAF2 PMC3674567__F4 Postulated model for regulation of large luteal cells of ruminants (left) and primates (right) PTGS2 CYP11A1 STAR PMC9398379__F2 Whiff of the future: functions of phenylalanine‐derived aroma compounds and advances in their industrial production CAD PMC7950231__F5 Induction of type I interferons and signalling leading to the innate immune response during SARS-CoV-2 infection and drug pair action site TBK1 IKBKE CHUK IKBKG TREML4 STAT2 IRF9 TRAF3 MAP3K7 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 STAT1 IKBKB NFKBIA OAS1 OAS2 OAS3 TLR7 NFKB1 TYK2 JAK1 PMC3720155__F2 Sketch of the relationship between IGF signalling, the PI3K pathway and androgen responses in the prostate IGF1 IGF2 PTEN INPP4B PMC8282456__F3 Recent Advances in Heterologous Synthesis Paving Way for Future Green-Modular Bioindustries: A Review With Special Reference to Isoflavonoids HMFN0839 MMP2 FOXO3A BMP2 MMP9 BCL2 MTTP BAX PMC7563527__F1 Versatile cross-talks of CAF with activated progenitor cells and HCC HGF SHH CCL2 TGFB1 PMC4522610__F1 Main extracellular stimuli and intracellular signaling pathways leading to astrocyte reactivity in ND CNTF COX2 SOCS3 GFAP HEL-S-44 IL6 IL1B TF STAT3 PMC10266770__F1 STAT2 deficiency and other inborn and acquired defects of type I IFN signaling result in susceptibility to viral infections STAT1 STAT2 TYK2 JAK1 PMC2944809__F5 Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence TBK1 TLR4 A2M MAP2K3 TNF TRAF2 STAT3 PMC4310697__F4 Toll-like receptor (TLR), nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), and retinoic acid-inducible gene (RIG-I)-like receptor (RLR) signaling CARD9 TRAF3 TRAF6 SYK IRF3 MYD88 CSA2 TIRAP PMC4173780__F1 Strategies for the production of linear, primary alcohols AHR HBD CRP FADD PMC8490190__F2 Emerging Nondopaminergic Medications for Parkinson’s Disease: Focusing on A2A Receptor Antagonists and GLP1 Receptor Agonists GSK3B MTOR FOXO1 PMC5497827__F1 Summary of the canonical Th2 pathway and “new spins” on the pathways that lead to allergic inflammation SOCS3 AHR IL13RA1 DENND1B STUB1 IL33 IL4 IL25 TSLP SOCS1 PMC4057583__F10 Link between NFKBIA and EGFR pathway in Glioblastoma NFKBIA EGF EGFR PMC7992789__F3 Roles of miRNAs in modulating the autophagy process in human breast cancer TSC2 PML ATG16L1 TSC1 ATG12 ATG3 SQSTM1 LAMP2 PTEN ATG10 DKFZp686F0183 NBR1 PMC8267830__F1 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network TH TSC2 GSK3B PTEN GRB10 DEPTOR PMC6367540__F4 Figure illustrates the signal transduction cascades of TGF/BMP, Wnt, Hedgehog signaling pathway in the development of cranial sutures DHH IHH KIF7 PTCH1 GLI3 SHH SMO SMAD1 DKFZp781O1323 PMC5869864__F3 mTORC1 as the main gateway to autophagy ULK1 TFEB AMBRA1 ATG101 PMC4643669__F1 Novel role of miR-33 in regulating of mitochondrial function NRF1 CPT1A SLC25A25 HADHB ABCG1 CROT ABCA1 PDK4 TFAM PMC5739091__F1 Rag GTPase-dependent amino acid signaling pathway upstream of mTORC1 SLC38A9 CASTOR2 CASTOR1 RHEB PMC3392447__F2 Routes of AMPAR trafficking GRIP1 KIF1A PICK1 PMC3081173__F4 Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology VTN ARHA SPRY2 CDC42 PMC8467578__F1 Looking at Alzheimer’s Disease Pathogenesis from the Nuclear Side TES GSK3B APP ADAM10 SIRT1 APOE PMC5223230__F1 A central role of Batf3 DCs and the STING pathway in orchestrating anti-tumor T cell responses BATF3 CXCL10 CXCL9 CCL4 PMC4074565__F1 Regulation of mTORC1 by amino acids NPRL2 FLCN SEH1L LAMTOR1 MIOS FNIP1 WDR24 GIP PMC9340325__F2 Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products NLRP3 IGF1 PTEN IL1B PMC7767850__F4 Immune escape through PD-1/PD-L1 pathway in B-cell malignancies APC CD80 B2M IFNG PMC6114981__F7 FABP5-mediated transcriptional controlling network of mitochondrial functions in PCa cells MFN2 FH ACO2 FABP5 PMC7767850__F3 PD-1/PD-L1/PD-L2 pathway hijacking in oncology GNAL CD80 IFNG PMC4364059__F2 TLR and NLR pathways ATG16L1 NOD1 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 NOD2 PMC7053056__F1 Kynurenine pathway represents one of three routes for NAD+ production or recycling PARP14 SIRT2 PARP10 ART5 AADAT IDO2 ART3 NMNAT3 PARG ART4 PARP6 PARP4 NMRK1 PARP16 PARP15 SIRT3 PARP8 HAAO HEL-S-90n KYNU GOT2 NMNAT1 SIRT4 SIRT5 SIRT6 NMNAT2 NADK2 SARM1 NADSYN1 NAMPT NADK PARP3 NAPRT IDO1 SIRT7 GIG8 NMRK2 PARP12 PARP11 AFMID SIRT1 PMC8267830__F2 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network RICTOR GSK3B PTEN GRB10 DEPTOR PMC4364059__F3 The inflammasome pathway NLRP3 IL16 NLRC4 CARD8 PMC3817019__F1 How the VEGF-A signaling pathway is linked to its main biological functions.Notes: VEGF-A can bind VEGFR-2 dimer PLCG1 NRP1 VEGFA NRP2 PMC3817019__F2 EGFR pathway and its main downstream effectors, PI3K/AKT and KRAS/BRAF/MEK/MERK.Notes: Activated AKT and MEK/MERK can induce cancer cell proliferation and invasion BRAF EGFR PMC4831838__F4 Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media MPO LYZ HEL110 S100A9 PIGR MUC2 CTSG PRTN3 ITGAM HEL57 AZU1 BPIFA1 DMBT1 ELANE BPI PMC7962349__F6 Intervention of natural products from traditional Chinese medicine on the TME TLR4 IRF3 STAT3 PMC4380398__F7 Pik3ip1 Modulates Cardiac Hypertrophy by Inhibiting PI3K Pathway EEF2K PIK3IP1 IGF1 EEF2 MTOR PMC5955471__F9 Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1 KEAP1 IRF3 BACH1 PMC4926194__F2 Known host targets of phleboviral NSs proteins in retinoic acid-inducible gene 1 (RIG-I) signaling and type I IFN induction TBK1 IRF3 TRIM25 MAVS PMC6844227__F14 KEGG pathway annotations of the PI3K-Akt pathway in non-small cell lung cancer BAD SP2 CDC37 PTEN RAC1 EIF4E MTOR IRS1 RHEB RXRA TSC2 BCR GAB2 MDM2 SYK EIF4B RBL2 CD19 PMC9301867__F5 Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation PIK3R1 HSP90AB1 CDKN1B EGFR VEGFA CXCL8 NTRK3 RB1 MTOR HRAS HDAC5 CDKN2A FOXO1 MAP2K1 IKZF1 CDKN1A MMP2 ERBB2 PIK3CA CCND1 SIN3A CP PMC4695847__F1 Functions of mono-ADP-ribosylating ARTD (ADP-ribosyltransferase diphtheria toxin-like) enzymes and of mono-ADP-ribosylating Sirtuins in signaling AHR SIRT4 SIRT6 GSK3B IL4 TOX PMC5593680__F1A Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials TSC1 FOXO3A EGFR EIF4E ACLY MTOR RHEB PMC7039855__F1 Wnt signaling pathways APC GSK3B ARHA TNKS ROR2 RAC1 BCL9 JUN ROR1 PMC7039855__F2 Wnt/Beta-catenin signaling in DCs and tumors in driving immune suppression and immune evasion XCR1 XCL1 LRP5 CCR7 LRP6 CCL4 CD80 MTOR IL1B TCF4 FOXP3 PMC3835153__F2 Cisplatin resistance.Notes: Cisplatin creates DNA adducts and activates the apoptotic pathway, thus killing rapidly dividing cells CASP3 ATP7B ERBB2 ATP7A PMC6386927__F6 THD on a crosstalk in Fzd/GSK3B/Beta-catenin/P62 axis APC GSK3B TCF4 PMC11747375__F3 GA inhibited the proliferation and migration of VSMCs ARHA PTEN RAC1 CDC2 CDC42 KSR2 PMC11747375__F1 Molecular targets and mechanism of action of GA in hyperlipidemia BAD UCP1 PGC NOS2 TNF HEL-S-104 BAX CD36 PMC11747375__F2 Inhibition of atherosclerotic lesions by GA NOX4 ARHA CDC42 KSR2 PMC3327724__F1 Heroin metabolic pathway in humans ACHE UGT2B7 UGT1A1 PMC8822594__F3 New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer ITGB4 CCND1 KLF2 LPP MYD88 MCL1 EZH2 CUL4A LAMC2 STAT3 PMC6244246__F5 Integrated transcriptomics and metabolomics pathway diagrams GNPAT CLPS CHKB LPA APOH LPCAT2 DGKA HEL-S-5 PMC5555522__F3 Molecular Pathway in Thyroid Cancer BRAF TSHR PTEN MTOR PMC7571161__F4 IFN signaling and synthesis pathway STAT2 IRF9 RIGI IRF3 TYK2 IFNAR2 ACE2 TLR3 MAVS PMC3822617__F3 Multifunctionality of ARC in regulating apoptosis signalling BAD ARC FADD BAX PMC7140698__F9 Effects of Dot1L inhibition in influenza virus infected cells TBK1 IRF3 TRIM25 DOT1L MAVS PMC8125073__F5 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation KDM1A ANK2 HEL-S-30 ELOC IGF2 EIF4E HIF1A MTOR RBX1 EIF4EBP1 HMOX1 CTGF FOXP3 ADRA1B MDM2 NCOA1 HEL113 NOS2 RPS6 TGFA ADM CP PMC4327623__F2 The main signaling pathways involved in the neuroprotective action of GDNF on dopaminergic neurons CASP3 RET GDNF BCL2 PMC8125073__F7 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation REN SMAD2 LYN LEPR MIP ECE1 BAX MAL PMC4926123__F7 Anti-tumor effect of Beta-glucan from Lentinus edodes and the underlying mechanism CASP9 PARP1 STAT3 BAX PMC4988449__F1 Schematic model depicting how ERK1/2 activity is transduced through the Shoc2 scaffold SCRIB SHOC2 ERBIN PPIC PMC8306148__F1 Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells KIF7 DISP1 APC GSK3B MTOR PYGO1 RHEB TSC2 SUFU GLI3 SHH SMO BCL9 PMC8917804__F3 Cellular and humoral host immune responses to SARS-CoV-2 viral infection STAT1 TLR7 CS STAT2 IRF7 IRF9 IRF3 TYK2 MYD88 ACE2 TLR3 MAVS PMC4613517__F1 Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress MAF KEAP1 RBX1 PMC11195429__F2 CGAS-STING signaling pathway KAT5 CGAS ENPP1 ZDHHC18 PARP1 USP35 SENP2 TNF OTUD3 TRIM38 SENP7 TTLL6 TTLL4 TREX1 DNASE1L3 TRIM10 PMC11195429__F3 Antitumor therapies awake the cGAS-STING signaling to accelerate the antitumor immunity CGAS CXCL10 CASP9 CXCL9 SLC19A1 PMC10308384__F5 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development CD59 TLR4 NPS CD55 AQP4 PMC5929409__F4A In vitro study on role of σB protein in avian reovirus pathogenesis HDAC3 RUNX2 P2RX7 BMP2 FGF2 MMP9 SMAD6 TGFBR2 FGFR3 SMAD4 FGF18 S100A9 HIF1A DDR2 SOX9 BMPR2 TLR4 WNT3A ELF3 ANXA2 S100A8 NOS2 SP7 FADD PMC9578963__F1 Orchestrated signaling by PI3KA and PTEN at the membrane interface TSC2 PI3 BAD TSC1 MAP4 MDM2 PTEN SNX27 RHEB PMC10308384__F9 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development TLR4 FOXJ1 PMC5666046__F3 Prolonged mechanical loading beyond physiological levels on tenocytes, increases the expression of IL-1B and CCL2 CCL2 IL1B PMC9396386__F6 Time-course transcriptome analyses of spleen in rainbow trout (Oncorhynchus mykiss) post-Flavobacterium psychrophilum infection CD14 CHUK CXCL10 MYC LY96 MYD88 IL12B PDC NFKBIA NFKB1 LBP GRAP CXCL11 PMC7610305__F1 Upregulated AspH activates the Notch signaling pathway RBPJ EPCAM ASPH CD44 CCND3 PCNA PMC406426__F1 What is the role of mTLR7 in the antiviral response? Many ssRNA viruses (including VSV and influenza viruses) engage host cell receptors that trigger endocytosis TBK1 TLR9 TRAF6 IRF3 IRAK4 MYD88 TLR3 PMC5677537__F1 Ethanol upregulates TNFA in Kupffle cells via the activation of multiple pathways Ethanol administration activates the TLR4 pathway, ROS production and complement activation to increase the expression of TNFA TBK1 HEL-S-62p EGR1 TLR4 IRAK1 TRAF6 IRF3 MYD88 TIRAP PMC4983472__F5 Intracellular and intercellular signaling and cellular dynamics in bone healing and bone remodeling RUNX2 BMP2 SMAD2 MSC PTH SMAD1 DKFZp781O1323 PMC8446672__F1 Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis TYK2 IL23R IRF4 STAT3 PMC5666046__F2 Effect of mechanical strain on tenocyte CCR2 PC CCL2 IL1B PMC3205681__F2 Post-translational modifications (PTMs) of transcription factors SRI OGA OGT VILL RHD MAFA PMC3993104__F2 Interplay between host and bacterial factors leads to tissue destruction, vascular leakage, and hyperinflammation in invasive GAS disease SAG PLG APC HEL-S-162eP PMC1327675__F3 Interactive map (pathway) of 46 genes/proteins created in PathwayAssist® from the list of transcripts up-regulated in the testes of ABP-transgenic mice CYBA MAP2 PGR MYC SLPI BTK A2M SHBG NFYC GDNF KLK6 CLN3 ETS2 CAD EGR1 LYZ CD44 ATF3 IL6 CFTR MYH6 NTF3 HEL111 MYF5 MME PMC6034133__F8 Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes TIAM1 RAC1 HDAC5 PMC5017163__F1 Different strategies of metabolic regulation in cyanobacteria: from transcriptional to biochemical control GCA HEL107 HPR GPD1 PMC6406345__F3 Protein–protein interaction network of associated genes in the etiopathogenesis of ANCA-associated vasculitis HLA-DPA1 NOTCH4 TLR9 CFB RING1 HLA-DQB1 HLA-DRB1 PTPN22 RXRB PRTN3 COL11A2 HLA-DPB1 AGER MICA HSD17B8 CD226 PMC6739476__F7 Pathway map assigned for MAPKs signalling MALL MIP ST14 ROM1 YOD1 MAL CD24 PMC11195429__F1 cGAS-STING and cell death pathways TBK1 CASP3 NLRP3 CGAS CASP9 RIPK3 IRF3 TNF ZBP1 MLKL GSDMD BAX PMC11682996__F1 Mechanisms of IFI44L in human diseases TBK1 TLR7 TREM1 RIPK3 IFNAR2 IFNAR1 BAX PMC5381938__F1 Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy APC CTLA4 IFNG PMC9314331__F5 S6K functions in feedback regulation TSC2 TSC1 GSK3B IRS1 HDAC1 PMC6755182__F8 Ginsenoside Rb1 prevent the steroid-induced avascular necrosis of the femoral head through BMP-2 and VEGF signaling pathway RUNX2 BMP2 RB1 PMC9522762__F2 Liver kinase B1 in tumor progression through regulation of lipid metabolism SIK2 SIK3 SRPK2 CRTC2 ACLY MTOR FASN CD36 PMC3708584__F3 ‘ErbB signalling' and ‘TGFB pathway' in the canonical pathway NRG3 EGF ERBB4 BTC NODAL PITX2 GRB2 HBEGF GSC MTOR NRG4 JUN PMC4351296__F6 Mechanism of dynamics of the EGFR-NHERF1-NHE1 signaling axis and its role in PDAC growth and invasion.In control cells EGFR, NHERF1, and NHE1 are separate EGF EGFR NHERF1 PMC3212439__F5 Immunoproteasomes Regulate Lps-Induced Trif/Tram Signaling Pathway in Murine Macrophages STAT1 TLR4 TRAF3 TRAF6 IRF3 MYD88 TNF PMC4624194__F1 STAT3 Signaling in Polycystic Kidney Disease EGF HGF SRC STAT3 PMC8418613__F4 STRING pathway analysis of LM and LuM CD11b+ druggable proteomic targets CREG1 MPO HEL-S-97n LGALS9 ACTN1 ALOX15 HEL-S-99n PDIA4 ALOX5 HSPD1 TTN PYGM PSMD7 LGALS3BP PGLYRP1 PTPN1 COL1A2 ELANE H1-10 LAMA5 APOE HMGB1 GNS ABCF2 LAMP2 MMP9 LAMB2 DECR1 CYBB ITGB1 ATP2B1 RPN1 NID1 MYH6 HEL-S-125m SIRPA MGST1 TUBB4B HSPG2 HP HEL-S-269 LYN ADAM10 TUBA1B ABCE1 PYGL STAT3 COL4A1 PMC6269503__F1 Role of Hippo signaling in regulating immunity CGAS CXCL1 IRF3 LATS1 MYD88 PMC3946526__F6 The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer CYP26A1 LRAT CYP26B1 PMC8026967__F3 Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome PALB2 FANCD2 SLX4 FAAP24 FANCM RAD51 RFWD3 FANCL FANCA FANCB FANCE FANCG RAD51C PMC5911217__F7 BRD7 regulates the insulin signaling pathway by increasing phosphorylation of GSK3B GSK3B BRD7 EIF4E MTOR MEA1 PMC6600376__F2 Mitogen-activated protein kinase (MAPK) cascades in activated, myofibroblast-like hepatic stellate cells (HSC/MFs) EGF PAX2 RHO CAD JUN CDC42 PMC6600376__F3 Major phenotypic responses in activated, myofibroblast-like cells (HSC/MFs) as well as, more generally, in hepatic MFs TIMP1 TGFB1 PMC11076734__F4 PINs-mediated auxin transport regulation during salt stress PIN1 SOS2 PIN4 PMC6600376__F1 ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis MMP12 HGF CXCR4 FGF2 MMP9 TGFA TGFB1 IFNG PMC3638125__F2 Intracellular signaling pathways of GLP-1R in the pancreatic Beta-cell ATF4 EGFR CCND1 FOXO1 PMC3172156__F2 RLR signaling pathway showing RIG-I bound to ligand RNA and signaling downstream to IRF-3 and NF-kB to induce IFNA/B production from a virus-infected cell TRAF3 IRF3 JAK1 PMC8908406__F1 Dawn of precision medicine in diffuse-type gastric cancer HGF FRS2 SMAD2 GSK3B GRB2 SMAD4 ARHA MTOR FGFR2 CPO PMC6121065__F1 mBDNF/TrkB and proBDNF/p75NTRsignaling pathways regulate gamma-aminobutyric acid neurotransmission SHE ARHA PTEN PMC11089157__F4 Post-translational regulation of FOXK2 ATM FOXO3A CAD MTOR FOXK2 SIRT1 PMC11089157__F5 Emerging roles of FOXK2 in cancers and metabolic disorders VHL REST TXNIP SIN3A EZH2 FOXK2 BAP1 PMC4335356__F4 Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases NGF CSNK2A1 FHL3 PRRT2 PPP4C HEL-S-87p CORO1A TAOK2 HIRIP3 UBC HEL-S-90n CDIPT APP INO80E JUN PCNA DOC2A MVP PAGR1 YPEL3 PMC11089157__F3 Transcriptional regulation of FOXK2 EGF EGFR FOXK2 SOX9 PMC9513364__F3 Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review BMPR2 RUNX2 BMP2 TGFBR1 TGFBR2 SP7 SMAD1 DKFZp781O1323 PMC2747343__F1 Ingenuity pathway analysis shows 17 genes from the 180 genes associated with the NF-E2-related factor-2 (NRF-2)-mediated oxidative stress response pathway LOC51064 FTL HSPB8 PROX1 HEL-S-22 DNAJC3 AOX1 HEL-S-165mP ATF4 CCT7 HEL-S-44 JUN PXN CP PMC11082402__F5 Riboflavin metabolic pathway FLAD1 HEL-S-10 PMC9357610__F5 Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF‐B1/Smad3 signalling pathway SMAD2 PMC5291771__F1 The signaling pathway of DDX41 in innate immunity TBK1 BTK TRIM21 DDX41 IRF3 PMC5528350__F1 miRNA deregulation in cancer AGO2 DGCR8 MYC DROSHA RAN XPO5 PMC7191850__F7 Graphical summary of MITF action as a potent antioxidant in RPE cells through regulating NRF2-dependant antioxidant signaling to protect the neural retina against oxidative stress-induced degeneration MAF GCLM GCLC RPE PMC10148080__F4 NAT10 as ac4C writer in diseases CEP170 CDK2 CCND1 NAT10 CDK4 BAX PMC4131779__F2 Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil FLI1 SMAD2 TGFBR1 TGFBR2 SMAD4 SP1 STAT3 PMC6144938__F3 Important steps in cholesterol synthesis and homeostasis DHCR7 ABCG1 DHCR24 LDLR CYP11A1 ABCA1 PMC3358533__F5 PPARA signaling canonical pathway in chronic arsenic-exposed lung epithelial cells COX2 HSP90AB1 DNAJB12 DNAJB6 HTT NR0B2 TRAF6 NR1C2 TRAF2 NR1C1 CITED2 PMC9284900__F8 METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner METTL3 DROSHA DKK2 PMC4267524__F8 Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer INA PTEN HDAC1 PMC7694477__F1 Hereditary hemorrhagic telangiectasia (HHT) and the transforming growth factor beta (TGFB) signaling pathway in endothelial cells BMPR2 BMP10 SMAD4 ENG ID1 SMAD1 DKFZp781O1323 PMC4197858__F2 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease SRM RPIA HEL107 RPE SMS PMC4197858__F3 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease GLO1 DHFR ARHA UBIAD1 HMGCR PMC7286357__F8 Proposed mechanism by which Xbp1s promotes inflammation and injury in renal tubular cells during AKI in sepsis CD14 TLR4 SOCS3 LBP XBP1 TCF2 PMC3836044__F1 Canonical (Wnt/Beta-catenin) pathway PIGO APC DKK1 PMC4504424__F2 Cytokines determined to be up-regulated in plasma collected from pancreatic adenocarcinoma patients FGF2 VEGFA IL17A CCL5 IL6 S100A9 IL4 PMC12106287__F1 Membrane receptor tyrosine kinases-linked anti-BC effects of flavonoids as modulators of the MAPK signaling pathway, highlighting their capacity to function as sensitizers in chemoresistant BC and/or as chemopreventive agents ATF2 RHO CDC42 PMC9476305__F5 Recent advances and limitations of mTOR inhibitors in the treatment of cancer TSC2 TSC1 IGF1R PTEN EIF4E MTOR IRS1 RHEB PMC6627216__F1 Synthetic lethality of PARP-inhibitors in HR-deficient tumors CHEK2 ATM ATR CCDC6 BRCA1 PMC9307349__F2 Active Compounds and Targets of Yuanzhi Powder in Treating Alzheimer's Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology SNCA PLK2 PIG59 MAP2K4 FOS CCL2 RB1 TNF IL6R NFKBIA MAP2K1 GABRA5 GJA1 CHRM1 opn F3 BCL2 ITGAV SLC1A3 PMC4555184__F3 Stem cell mechanobiology: diverse lessons from bone marrow RHO LMNA PMC6359168__F3 Apoptosis induced by Endoplasmic Reticulum (ER) stress ATF4 BCL2 TRAF2 PMC3906332__F4 Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells SOX2 MTOR INSR PMC7255038__F3 Schematic diagram representing interplay between metabolism and epigenetics ME1 ME2 OGT SIRT6 ME3 SIRT1 PMC3575604__F1 Evolution and impact of subclonal mutations in chronic lymphocytic leukemia ATM POR PMC9405286__F1 Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review SOX2 ATG3 SMAD2 EGFR FTL TFRC MYD88 MTOR TLR4 ATM CCND1 CDK4 CDH2 STAT3 BAX PMC9503837__F2 Histone acetylation dynamics in repair of DNA double-strand breaks ATM MDC1 HMGN1 PMC5037390__F6 Hypothetical mechanistic network derived from predicted upstream regulators for genes found to be differentially expression in chondrocytes in transition from monolayer to alginate bead cultures (redifferentiation) BHLHB2 EGR1 FOS NFE2L2 ATF3 CXCL2 HIF1A SOX9 NFKBIA ATF4 COL2A1 JUN GPNMB APOE PMC6710759__F1 Schematic KEGG map representations of signaling pathways involved in Alzheimer's disease (a), Parkinson's disease (b), and amyotrophic lateral sclerosis (c) SNCA BAD GSK3B NEF3 NEFH TNF CASP3 IMPA2 APAF1 LPL APP CASP9 APOE CCS NEFL PMC9398942__F5 Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise PDE5A PMC7593920__F3 The HMGB1 signaling pathway HMGB1 SP1 SELE CP PMC8165220__F3 Rac1, A Potential Target for Tumor Therapy ROCK2 RAB35 OIP5 PLS1 ARHGAP24 RAC1 NRP2 BMPR2 PAK1 MMP2 ERBB2 IQGAP1 SEMA3C JUN VAV2 CDC42 PMC3312932__F2 Regulation of the human catalytic subunit of telomerase (hTERT) INHBC E2F4 MNT IGF2 CTCF MDM2 SMAD4 SP1 MTOR TERT PMC6662580__F1 Hippo pathway HIPK2 BTRC HEL2 AMOT HEL-S-1 LATS1 MOB1A WBP2 MOBKL1A LATS2 TAOK1 NF2 CRB3 CSNK1A1 RASSF6 TP53BP2 WWC1 ANKRD17 ANKHD1 AJUBA SCRIB CTNNA1 PATJ RASSF1 STK4 PTPA FRMD6 PMC8978518__F9 Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan‐cancer analysis APC LRP5 LRP6 AXIN2 TF PMC2442833__F1 Metabolic network of oryza sativa L GIP CIT MAL PMC6585737__F1 Receptors and signaling pathways mainly contributing to anti‐inflammatory polarization of microglia SOCS3 NGF NOX4 AXL SOCS1 STAT3 PMC3996671__F1 Ras and autophagy in cancer development and therapy ULK1 RAC1 MTOR DKFZp686F0183 PMC9471064__F4 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets TRADD TRAF2 FADD BAX PMC6585737__F3 Metabolic drugs and molecular pathways exploitable to drive microglia into a pro‐regenerative phenotype MOS ARG1 SIRT1 PMC9471064__F5 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets ULK1 ATG3 AMBRA1 ATG101 MTOR ATG14 PMC2758611__F6 Schematic presentation of the proposed TGFB signaling alteration that promotes HNSCC in mice SMAD2 TGFBR1 TGFBR2 SMAD4 PTEN HRAS PMC4724815__F6 Long non‐coding RNA urothelial cancer‐associated 1 promotes bladder cancer cell migration and invasion by way of the hsa‐miR‐145–ZEB1/2–FSCN1 pathway ZEB2 CDH2 PMC3444139__F3 NFKB signaling pathway in ATL RELA RELB CD40 LTBR PMC8740004__F6 FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma HDAC3 FOXA1 PMC4689294__F1 Wnt canonical and non-canonical pathways DAAM1 APC GSK3B LRP5 LRP6 ARHA ROR2 PMC4049685__F2 Colorectal cancer metastasis signaling pattern CDA EGF BAD E2F4 SMAD2 EGFR MYC RHO DVL1 COX2 GRB2 UNK JUN PMC6947613__F1 Molecules and pathways involved in the effect of statins on NO production by endothelial cells CRP RHO RAC1 PMC2834303__F9 PI3K-Akt pathway negatively regulates LPS signaling and gene expression in mouse macrophages by inhibiting the activation of MAPKs EGR1 ATF2 PTEN TNF TF PMC4568768__F1 FSH signaling FSHR PMC4022041__F3 Genes involved in the TGF beta signaling pathway after 5 days NODAL SMAD2 SMAD4 ARHA THBS1 RBX1 PMC4279731__F7 RBP-J acts as a master regulator that maintains the identity of the JG cell SRI NFATC4 CRIP1 FCAMR MYOCD KLF4 GATA6 HEL-S-14 PMC5992182__F6 RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors BRAF CYLD PMC8812234__F6 IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer AMER1 CD44 PMC8082456__F1 Key Role of NAD+ in Anti-Tumor Immune Response: An Update CGAS PMC8481577__F6 TNF-Alpha Pathway Alternation Predicts Survival of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer CXCL10 CXCL9 HEL-S-92n TNF PMC3824101__F1 Mechanisms involved in type I IFN production and its receptor signaling TBK1 CGAS TLR9 STAT2 IRF7 IRF9 IRF3 MYD88 NOD2 TLR3 STAT1 TLR8 TLR7 TLR4 NOD1 TYK2 JAK1 MAVS PMC8070209__F10 Pathway involved in the synthetic lethality of PARPi with combination of cisplatin on Twist knockdown CisR OC cells CASP3 CASP9 BAX PMC5058735__F9 Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation MYCL MYC TP73 PMC3754247__F2 Oncometabolites: linking altered metabolism with cancer KEAP1 FH ACO2 MAL PMC4939268__F1 Metabolites involved in Glycolysis and Amino Acid Metabolism are Altered in Short Children Born Small for Gestational Age RPS6KA1 LPL PRODH TNF PMC7471342__F1 Top 25 mRNA-hub genes in baseline analysis HEL2 EGFR WWP1 CDC34 TSG101 FYN RPS2 APP FAT10 RPS6 JUN RPS20 RPL3 RPLP0 RPS14 CSK HEL-S-28 SKP1 PARP1 RPL4 RPS16 RPS9 ERBB2 RPS3 PSMD4 PPARG SHC1 ITCH PMC8810966__F12 Sex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine BRAF HEL-S-11 CREM SMO RAF1 HEL-S-14 PMC9170928__F8 Chicken telomerase reverse transcriptase mediates LMH cell pyroptosis by regulating the nuclear factor-kappa B signaling pathway NLRP3 GSDMA IL1B IFNG PMC11994599__F9 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges TLR4 NOX4 MYD88 BAX PMC11687105__F1 M(6)A biological functions CXCL1 SOCS2 SOCS3 NPNT FOXM1 MTOR DKFZp686F0183 YTHDF1 PABPC1 CCND1 BHLHE41 FASN YTHDF2 KIT SOX2 ABCC10 POLK IL8RB FGF16 CISH AAG1 VIRMA SOHLH1 BDNF SOCS1 PMC11994599__F7 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges MMP2 SMAD2 MMP9 SMAD4 SMAD1 DKFZp781O1323 SMAD9 PMC11687105__F2 Therapeutic potential of RNA m(6)A in lung cancer SOCS2 IGF2BP1 KEAP1 FOXM1 SLC7A11 FLT4 AKR1C1 PTEN ALKBH5 WTAP MTOR IGF2BP2 TRPM7 PLOD2 YTHDF1 IGF2BP3 YTHDC2 CYLD TIMP3 HNRNPA2B1 JUNB EZH2 H2AX DLGAP5 MZF1 YTHDF2 FRAS1 ATG12 FAM83D ID3 TK1 METTL14 UBE2C DAPK2 PINK1 RAC3 METTL3 CDC6 DCP2 TWIST1 HNRNPC AXIN1 HOXA1 TNS1 VIRMA COL10A1 BRD4 PMC3760860__F6 Organized Emergence of Multiple-Generations of Teeth in Snakes Is Dysregulated by Activation of Wnt/Beta-Catenin Signalling LEF1 SOX2 GSK3B PMC8173116__F2 Monochromatic Lighting During Incubation and Vaccination on the Splenic Transcriptome Profiles of Chicken CTRL PDIA2 TNF C1QTNF6 PMC7922079__F4 Targeting EPC expansion as a novel therapeutic strategy TPH1 MTOR GATA1 PMC8801576__F8 Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway IL10 TGFB1 IFNG PMC12055897__F2 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications PTEN JUN PMC12055897__F5 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications EGF EGFR PTEN PMC4668540__F1 Sonic Hedgehog Pathway PTCH1 GLI3 SHH SMO PMC7075017__F1 Fanconi anemia pathway of DNA repair REV1 FANCD2 BLM PARP1 TRAIP MRE11A FAN1 GIG8 POLE RAD52 RAD51 FANCA DNA2 PMC3998839__F1 mTORC1 is a component of mTOR that is directly inhibited by rapamycin and rapamycin derivatives like everolimus TSC2 EEF2K EGF BAD TSC1 IGF1 CCND1 BCL2 PTEN EIF4E EIF4B RHEB PMC7862491__F2 Expanding the role of proteasome homeostasis in Parkinson’s disease: beyond protein breakdown STAT1 DDI2 NRF1 KEAP1 JAK1 IRF-1 PMC6382377__F1 Lymphopenia and DMTs for relapsing forms of MS HEL-S-171mP DHODH ELL PMC7999163__F2 Possible mechanisms through which the gut microbiota could affect the homeostatic and hedonic pathways PC NPY AgRP PYY ARC PMC8169406__F5 Strategies to restore NO bioactivity GC ACE2 PMC6352225__F6 Schematic illustration of the role of human papilloma virus (HPV) oncoproteins in the production of macrophage migration inhibitory factor (MIF) MTOR HEL-S-133P PMC7354740__F1 Leptin action in granulosa cells GRB2 IRS1 PMC7261627__F2 New insights into progesterone receptor signaling in the endometrium required for embryo implantation MUC1 PGR WNT4 BMP2 WNK1 EGFR SMO SOX17 HAND2 FOXO1 GATA2 PMC8724833__F7 Schematic figure of the action of OASL in pulmonary viral infection OASL CGAS TLR7 TLR9 AHR IRF7 TRAF6 IRF3 MYD88 TLR3 MAVS GATA3 PMC12158553__F1 Cellular heterogeneity between OA patients and non-OA controls CD163 PROC CD44 IL8RB GDF10 CXCL12 TNF CD74 GRP CYTL1 PMC6718311__F1 Pro-apoptotic JNK pathway is strictly restricted in neurons BAD DUSP16 BMF HRK PMC4685734__F5 Apoptotic cell recognition receptors and scavenger receptors ARHG VAV1 ARHA MEGF10 RAC1 PMC8935239__F9 Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells ATF4 EIF2A PMC4685734__F6 Apoptotic cell recognition receptors and scavenger receptors MEGF10 RAC1 ABCA1 PMC5335589__F5 The extrinsic pathway of the coagulation cascade was investigated in our study IL1A TFPI VWF PMC7010798__F7 Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway RUNX3 RUNX1 ATF2 WNT9B LRP5 PTK7 FZD4 DKK1 TNF SFRP5 NLK SFRP1 PPARG JUN CDC42 PMC11487499__F2 SPOCK1 promotes cancer occurrence by inducing the PI3K/Akt signaling pathway (by Figdraw) PSAT1 ATF4 PHGDH PMC9548471__F1 Genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease SOCS3 TYK2 SOCS1 STAT3 PMC3572392__F4 Almost all Theileria annulata proteins involved in glycolysis and citric acid cycle were identified in the study CS PC FH OGDH HEL-S-68p HEL-S-162eP PMC5124549__F1 Redox Biology and the Interface Between Bioenergetics, Autophagy and Circadian Control of Metabolism OGT KDM3A TF PMC3984540__F6 S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment care mediated by Gi and Rac MMP2 RHO CDH2 PMC11988162__F1 Illustration of the MAPK (left) and JAK/STAT (right) signaling pathways PTPRC ATF2 MYC RHO JUN CDC42 PMC11274390__F1 Zn and Cu in the synapse under physiological and pathophysiological conditions: (A) Roles of Zn and Cu under normal physiological conditions MT3 ATP7A APP PMC6358740__F6 Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update TLR7 TRADD IRF7 EIF2A TRAF3 TRAF6 IRF3 MYD88 FADD TLR3 PMC3478307__F2 Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K TRAF6 IRAK4 MYD88 PDPK1 PMC9094075__F1 Drug resistance in targeted cancer therapies with RAF inhibitors EGF BRAF EGFR GRB2 PMC7282681__F2 Schisandra chinensis on Alzheimer's disease signaling pathway CASP3 BAD APAF1 LPL CASP9 APP TNF DCC FADD APOL1 PMC3805993__F2 Novel KP/KISS1R signaling pathways in breast cancer cells lacking the estrogen receptor, ERA MMP9 EGFR IQGAP1 ARHA CDH2 PMC3104724__F2 This figure outlines the role of KLF10 protein as a target and as a regulator of the TGFBeta-Smad 2,3 signaling pathway SMAD2 KLF10 SMAD4 PMC8869601__F6 Potential Citrate Shunt in Erythrocytes of PKAN Patients Caused by Mutations in Pantothenate Kinase 2 HEL-S-26 ACLY HEL60 PANK2 L2HGDH PMC7268922__F3 Function pathway analysis between COPD and the two genes: CD38 and TNFRSF12A HMGB1 EGF TNFRSF12A FOXO3A IL13 FGF2 MAPK14 ARHA IL6 TNF IFNG CASP3 KL ERBB2 IL2 TRPM2 TGFB1 SIRT1 IL1B PMC3175639__F2 Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2 VEGFC GBP1 PMAIP1 TXNIP IL6 SAMD9 CEACAM1 CEACAM6 IFNG ZBTB32 PMC5559046__F3 Cooperation of 20HE, IS, and TOR signaling pathways in the regulation of fly larva growth and development TSC2 SHD TSC1 GIG8 ND2 PTEN ID1 RHEB PMC6601021__F1 Activation of the UPR pathway in tumor cells ATF4 EIF2A RTCB PMC3657461__F3 PI3K/AKT signaling in prostate cancer FKBP5 PTEN CCL2 CDH2 PMC3657461__F4 The JAK/STAT signaling in prostate cancer ATF3 IL6 BRCA1 STAT3 PMC5767254__F1 myomiRs and muscle mass wasting and atrophy pathways IGF1 FOXO3A TWIST1 YY1 TFRC EIF4EBP1 HTR2A MTOR EIF4E3 PMC3657461__F5 ERK and PI3K activation and their crosstalk BAD GRB2 PTEN HRAS JUN PMC5767254__F2 Exosomal microRNAs (miRNAs), proteins, and muscle mass wasting TLR7 ATG12 FOXO3A IRAK1 TRAF6 IRAK4 MYD88 PMC3657461__F6 TGFB/SMAD signaling pathway and its implication in prostate cancer BMP10 SMAD2 SMAD4 PMC3657461__F7 Wnt signaling and its implications in the development of prostate cancer APC GSK3B MYC LRP5 LRP6 PMC8104964__F1 TLR4 signaling pathways TBK1 CD14 IRF7 TICAM2 CXCL10 TRAF3 TRAF6 IRF3 IFNB1 MYD88 TNF TICAM1 TLR4 LBP TIRAP PMC2729321__F3 Is NFKB a good target for cancer therapy? Hopes and pitfalls TRAF5 CYLD RELA TRAF3 RELB TRAF6 TRAF2 MLN PMC3264131__F1 Metabolic pathway of C PC HEL-S-162eP PMC4591954__F1 Therapeutic targeting of the canonical WNT pathway APC GSK3B CD44 TNKS GPR49 PMC3657461__F1 Androgen receptor (AR) signaling in prostate cancer EGF PTEN STAT3 PMC5854649__F1 TLR4 signaling pathway CD14 BTK TLR4 IRAK2 TRAF6 IRAK4 ECSIT MYD88 MAP3K7IP1 IL1B MAL PMC7765557__F2 Leptin-induced signaling pathways SOCS3 ROCK1 EGFR ARHA PTEN MTOR FOXO1 RS1 POMC NPY AgRP GRB2 SRC STAT3 PMC9530148__F3 Astrocytes in neuropathic pain CNTF CXCL1 MMP2 LIF MMP9 S1PR1 RGMA ARHA CCL2 RAC1 OLIG2 STAT3 PMC8351219__F4 Molecular mechanisms of action of Nutlins in neuroblastoma cells HIPK2 MDM2 PMC2597498__F2 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway TSC2 RICTOR EIF4E MTOR RHEB PMC2597498__F4 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway EIF4E RHEB PMC12104071__F2 Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis PTEN RHEB PMC3810594__F1 Renin-angiotensin-aldosterone system and regulation of insulin signaling phosphorylation of docking protein insulin receptor substrate -1 (IRS-1) is the major converging point in insulin signaling MTOR IRS1 PMC6966713__F5 Linear ubiquitination and NFKB activation TRADD IRAK1 IRAK2 TRAF6 IRAK4 MYD88 RIPK2 TNF NOD2 RIPK1 TLR4 TRAF5 SHARPIN TRAF2 PMC6800142__F7 TGFB receptors activate Smad signaling and non-Smad signal transduction pathways SMAD2 SMAD4 TRAF6 PMC5672637__F10 Schematic diagram for the functional mechanism of Aster glehni extract IL6 ACLY TG HMGCR PMC5668426__F7 AGEs-Cyr61-VEGF pathway observed in this study MMP2 RPE STAT3 PMC8817869__F7 Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling PCK1 SIRT1 FOXO1 PMC11547603__F1 Activation of the components of the TGFB/Smad canonical signaling pathway initiates the fibrosis process by inducing transcription of the downstream fibrotic genes TGFBR1 TGFBR2 PMC11547603__F2 Activation of TGFB stimulates NFKB and MAPK signaling pathways with the subsequent activation of the Wnt/Beta-catenin pathway TGFBR1 TGFBR2 TRAF6 TRAF4 PMC6368618__F8 Decidual RANKL/RANK interaction promotes the residence and polarization of TGFB1-producing regulatory GD T cells CD80 FOXP3 PMC11547603__F3 Activation and interaction of both canonical Wnt signaling and non-canonical Wnt/TGFB SMAD2 APC PMC4879891__F1 Canonical Wnt signaling pathway APC TEF LRP5 LRP6 PMC9141076__F3 An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis AHR NFATC1 CYP1A1 PMC11547603__F4 Interaction between non-canonical Wnt/Beta-catenin and TGFB/Smad signaling pathways to stimulate the fibrogenesis process and transcription of the downstream fibrotic genes SMAD2 WNT5B FZD8 PMC11547603__F5 An overview of role of TGFB in the pathogenesis of intestinal fibrosis TIMP1 MMP9 COL1A2 PTEN MTOR COL1A1 PMC11555136__F5 Signaling pathway involved in the development of persistent bladder hyperalgesia HMGB1 TLR4 MYD88 PMC2949659__F1 Tamoxifen metabolic pathway CYP2B6 CYP2C19 CYP3A4 PMC11175075__F1 Jasmonic Acid on Stress Response and Quality Formation in Vegetable Crops and Their Underlying Molecular Mechanisms MYB MYC PMC5897904__F2 Genes mapped to the IL-6 pathway by IPA Software MAPKAPK2 FOS CRP MAP3K7IP1 TRAF2 PMC12066244__F7 Action of Osteo‐F in osteoarthritis IL13 MIA IL4 COL2A1 PMC3462935__F5 Schematic diagram depicting the potential interactions between EGF, S100A11, and Ca2+signaling pathway in human endometrial cell IL15 LIF EGFR HEL-S-43 PMC9658491__F4 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review RUNX2 SMAD2 SMURF2 TGFBR1 SMAD6 SMAD4 DLX5 SMAD1 DKFZp781O1323 PMC9658491__F5 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review APC GSK3B PMC5359577__F10 Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells HEL-S-11 TRPM2 PARG PMC8618701__F5 Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum GFAP RHO PARG CYFIP1 PKN1 TGFBI CDC42 PMC2043401__F1 Schematic outline of fatty acid synthesis in apicomplexans LIPA CP MAL PMC8627049__F7 Integrated DIA proteomics and lipidomics analysis on non-small cell lung cancer patients with TCM syndromes ANGPTL3 PCSK9 PC LPL LDLR HEL-S-128m TG PMC6237564__F7 Stimulation of autophagy by MAC in lung cancer cells TSC2 BNIP3 MTOR PMC5543726__F2 REV1 and DNA polymerase zeta in DNA interstrand crosslink repair REV1 FAN1 FANCD2 POLK SLX4 EME1 XPC MSH2 RAD18 PCNA PMC5542201__F3 Effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS) TSC2 BAD TSC1 PTEN RHEB PMC9549801__F1 Relationship Between Ferroptosis and Diseases GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 ADA SLC3A2 TF PMC12105125__S1 Schematic diagram of this study PC CXCL10 IRF3 IL6 TNF PMC4779714__F4 Identification of compounds that modulate retinol signaling using a cell-based qHTS assay SRC SYK STAT3 PMC8418074__F4 Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling CD3D KEAP1 EGFR APC MYC PTEN RB1 MTOR CDKN2A FBXW7 KRT6B KRT6C CREBBP EP300 ATM GRB2 NOTCH1 CDK4 JUN STAT3 PMC9134657__F2 New therapeutic targets in ovarian cancer through identifying significantly non-mutated genes SMARCA4 COPS5 TRPV6 TBR1 TRAPPC9 TOR1AIP2 BRWD1 PMC7555718__F4 Osteoclasts and Microgravity BTK NFATC1 OSCAR TEC SYK PMC8946555__F1 Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer ADA NTS ADK PMC8914608__F2 Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease DPP10 IL13 IL33 CD40 IL6 IL4 IL25 TSLP PMC6827304__F5 DAMGO and morphine differentially assemble protein-interaction networks to control MOR spatiotemporal signaling JUP DSG1 IQGAP1 DSC1 RAC1 ADRBK1 CRKL PMC2749695__F4 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target BMPR1A APC MYC MDM2 CCND1 PTEN MTOR RHEB PMC2749695__F5 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target TSC2 VASP BAD MYC MDM2 PGC MTOR RBL2 RHEB CFTR PMC2575629__F3 Alternative pathway of NFKB activation TRAF3 CD40 REL LTBR PMC7750705__F1 Roles of MGO in modulating cell signaling pathways, host immunity, and antiviral activity HK2 ELL BAX PMC4784386__F4 Functional interaction network of the final set of 50 genes prioritized with the consensus strategy and 100 additional interacting genes SRP54 NRF1 CSNK2A1 PYGB MAGOH DRD2 SF3A2 CHMP1A FYN GOT2 NDUFS1 NDUFA12 OGDH EZH2 SNRPA1 PDHX RPE SNRNP200 SNCA SLC25A20 SET DLD CHMP3 RNF2 SHOC2 MCM7 SNRPC CBX4 MCM3 MCM5 TRPC1 CIRBP GTF2E1 GTF2E2 CDC6 SRP68 CHMP2A RCN2 ERCC2 TH NCBP2 CS SNRPG SNRPA DBF4 ESRRA ORC3 ORC2 MNAT1 PHC2 APP DLAT PRPF8 SRP14 NCBP1 RGS4 CHMP4C SNRPF CHMP4B DBT NR1C1 NDUFA2 HNF4A SNRPB ORC1L ROBO1 PPARG PYGL AGL SRP19 PMC4784386__F5 Functional interaction network comprising gene sets prioritized by Limma and ML FOXO4 AGTR1 F8 BMI1 NNT NRXN3 DRD2 RPS29 MDH2 FRY STAT1 HEL103 VBP1 PNMT CDK14 MASP2 SPTAN1 SYT17 RBM4 SCG2 CHGB RELN APC NPPC REG3A IL15 CIRBP COPS4 SLC18A2 LILRA1 GOLGA1 PPP2R5C BANF1 ABCB9 ZFP37 ZNF547 SESN1 SCN1B SCNN1A ACP2 RBFOX2 RPL7 TMOD3 VRK3 ACTG1 CRYZL1 HECA MAGED1 SUMO3 HIGD1B SLC25A32 PSG1 GMCL1 SCN3B VAT1 SS18L2 GPR161 CRIM1 P4HA1 HEL-S-101 CCNH PSMG1 POLG VPS4B PCDHB8 RLBP1 GNGT1 BCAS2 SYNGR3 CDH19 SMPX CXXC1 STX10 PDE6C TPBG WDR11 PDCD2 NFYB RBL1 RGS4 KERA SYT1 SELPLG CLK1 ARL1 MT1G SPTLC2 OXCT1 P2RX7 PRELP FBLN5 HEL32 SMARCA4 BMPR2 SIRT4 INSM1 PAICS ROR2 HEL20 STRAP EN1 RAD21 PYROXD1 IMMT QPCT RUNX3 ATG12 PCDH8 TLK1 E2F5 DLD SHOC2 CACNB3 RBM3 RET SYCP1 KCNJ2 RCN2 SNX4 ATR TH CTDSP2 PF4V1 SMAP PLOD1 PTPRN2 ITGA7 CCNC ESRRA PPM1B INSR KCNJ6 PKD1 MAGI1 C1orf21 ADGRB3 DKFZp434N041 CHST3 IGSF1 MMD BAGE NRG1 PBX1 MSTN PDK4 CHEK1 PEX3 TLL1 AHSA1 LMAN2 HLTF PMC3728089__F5 Cholinergic anti-inflammatory pathway ERBB4 TLR4 STAT3 PMC12229708__F7 Uterine stromal MEN1 regulates stromal decidualization and epithelial differentiation IGFBP1 DKK1 ME3 HAND2 PRL PMC5963742__F5 BPA increases downstream survival proteins and GPER while attenuating the growth inhibitory effects of EGFR inhibition EGFR HEL-S-44 HEL-S-162eP PMC5486049__F5 Scheme representing major factors of CWIP and the calcineurin signaling pathway ROM1 CDC42 PMC11618518__F4 Macrophages in organ fibrosis CCR2 IL13RA1 SMAD2 VTN CCL2 TNF IL1B PMC11618518__F1 Molecular mechanisms of tissue fibrosis SMAD2 RELA IL33 SMAD4 RHO MTOR PMC7461575__F4 Integrates stress response (ISR) in the context of muscular disorders ATF4 TIA1 PMC8632384__F9 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder HEL-S-11 TRO TNF FADD PMC8708342__F2 Species-Specific Differences in Aryl Hydrocarbon Receptor Responses: How and Why? AHR KLF6 PMC5931110__F1 Immune activating and suppressive effects of DNA double-strand break (DSB) signalling ATM ATR IRF-1 PMC9320222__F9 Ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells RAD1 RAD17 ATM RPA1 BRCA2 HUS1 RAD50 NBN RAD51 ATR MRE11A BRCA1 PMC3632591__F7 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats CCNA2 PLK1 EHF NEF3 CCNE1 HEL57 NUF2 PRC1 opn MDM2 PTTG1 STAR ELAVL2 NSL1 MYBL2 GULP1 MAD2L1 ACTA1 NRCAM CDKN1C AURKB HEL-S-22 PLN MCM3 MYBL1 VLDLR MCM6 MMP12 CDKN1A BRCA2 PSAT1 HEL164 SMC4 INHBA NEFL BOK PMC7471342__F2 Top 25 mRNA-hub genes in delta analysis FGA SNCA CCR2 EEF2 HEL-S-101 CRK EEF1G HEL-S-162eP HEL-S-102 TSG101 CCT4 APP AGAP2 APOE PMC3632591__F8 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats INA EGF PRRG4 SULF2 EZR GNAI1 THRA NUF2 PRC1 ECT2 MMP2 APP CDC2 STAR PMCH VEGFA XPC UGDH CENPE HCTP4 CFTR HEL-S-22 PLN SMC2 FADS1 MME PMC8229605__F1 Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPRER) and Beyond ELF2 ATF4 PMC8623349__F7 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis MAP2K4 ATF2 MYC PTEN MYH7 EIF4EBP1 MAP2K3 RCAN1 MAP2K6 CTF1 UNK HDAC2 JUN MAPKAPK2 NPPA MAPK7 MYOCD LIF NPPB MAP3K7 MAP2K5 ARHA TNF CYBB PRKD1 IKBKB PLN TSC2 EDN1 IGF1 MAX PMC8623349__F6 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis CANX AMFR EBP HEL-S-99n BCL2 VCP TRAF2 XBP1 PMC4777991__F1 Regulation of insulin-like growth factor signaling pathway by microRNAs in hepatocellular carcinoma IGF2BP1 IGF1R IGF2BP3 IGF2BP2 IGF2R PMC5818278__F2 Synthetic scheme of CS oligosaccharides using enzymes COMP PNP PMC5509150__F4 Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival CYP2C9 CYP4F2 CYP4F8 PMC7026059__F5 Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway CS HP SUCLA2 PMC3310225__F10 Protein Kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development WNT4 FGF8 CREM PMC6600639__F1 Upon T-cell receptor (TCR) signaling, the protein arginine methyltransferase PRMT5 interacts with DUSP14 and induces its methylation on Arg17, Arg38, and Arg45 residues DUSP14 MAP3K7IP1 TRAF2 PMC8186314__F1 GLI1: A Therapeutic Target for Cancer BRAF SUFU SHH SMO PMC6903391__F3 Epigenetic changes induced by iAs CTH HEL-S-61p AS3MT PMC5812824__F2 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression GNRHR SKIL FOS FSHB PMC11559183__F1 Regular neuregulin 4 (Nrg4)-erb-b2 receptor tyrosine kinase 4 (ErbB4) signaling pathway EGF ERBB4 NRG4 PMC7916440__F2 Simplified overview of major protective signaling pathways involved in RIPC, the reperfusion injury salvage (RISK) pathway, and the survivor activating factor enhancement (SAFE) pathway BAD GSK3B STAT3 BAX PMC9219813__F2 Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface S1PR2 S1PR1 S1PR3 S1PR5 RHO S1PR4 PMC5812824__F1 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression GNRHR SNURF LHB PMC5063512__F6 Schematic showing the mechanism of IGFBP-2-mediated regulation of Beta-catenin pathway in glioma cells involving A5B1 integrin, FAK and GSK3B MMP2 GSK3B IGFBP2 PMC10514503__F2 S1P maintains the intestinal intraepithelial EC barrier APOM S1PR2 S1PR5 RHO S1PR4 SPNS2 PMC10514503__F3 S1P protects the intestinal barrier through multiple means IL18 S1PR2 S1PR1 ARHA S1PR3 S1PR5 SPHK1 S1PR4 STAT3 PMC7102936__F3 mTOR at the nexus of nutrition, growth, ageing and disease FLCN SLC38A9 FNIP2 EGFR GSK3B GRB2 CASTOR1 PTEN SESN2 TNF RHEB PMC9221318__F4 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction PTCH1 GLI3 SRC SMO ARHA RAC1 MTOR PMC9221318__F3 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction GLI3 SMO PMC9471064__F1 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets RIPK1 GPX4 TRADD RIPK3 CDC2 MTOR ATR TRAF2 FADD MLKL BAX PMC9219426__F1 Mitochondrial DNA in dynamics of the immune response to COVID-19 TLR9 MYD88 ACE2 TMPRSS2 PMC7102936__F5 mTOR at the nexus of nutrition, growth, ageing and disease NF1 PC PTEN BDNF RHEB PMC6831883__F3 Timing Analysis and Its Results for the Citric Acid Cycle(A) Timing analysis NOG CTRL CIT MAL PMC6433665__F3 Common alterations in fluorosis‐proliferation and differentiation SMAD2 FGF2 SMAD1 DKFZp781O1323 BMP4 SMAD9 PMC5166550__F9 Signal pathway of IGF-1 by exercise IGF1 MTOR PMC6315103__F1 ProQ-dependent changes in Salmonella-infected HeLa cells TUBA1A RRAS ATR PMC3623009__F1 Simplified scheme of the complement activation network HEL-S-62p CD59 C4B_2 CD46 FH CD55 CR2 CLU CP PMC7466665__F3 Role of LPA on Hippo-YAP mediated osteogenesis, angiogenesis and osteoimmunology ANGPT1 IL16 RUNX2 CXCL9 LATS1 LPA ARG1 PMC9456385__F1 Reactive Oxygen Species and Long Non-Coding RNAs, an Unexpected Crossroad in Cancer Cells KEAP1 ATM MDM2 PTEN TNF MTOR BAX PMC9221389__F8 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction CD14 MAPKAPK2 NGF EGFR MAPK10 MAPK7 MYC MAP2K2 RRAS2 AGER MAP3K14 MAP3K8 HSPA1A JUN AKT3 PMC8770807__F1 Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia SYK FLT3 IFNG FOXP3 PMC9221389__F9 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction MAP3K1 CASP9 GIP RHO MYD88 TIRAP PMC4456045__F3 Negative feedback cross talk between PI3KA/Akt and NFKB signaling pathway by a local brief stimulation of TLR9, a potent preconditioning tool for programming the subsequent responses to I/R injuries and stimulation by TLR2, TLR4, or TLR5 ligands TBK1 CD14 NFKBIA TLR9 ATF2 TRAF3 TRAF6 IRF3 PMC4456045__F1 All TLRs signal through the common MyD88-dependent pathway MYD88 MTOR MAL PMC7736343__F7 An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells TFEB PTEN VMP1 STAT3 PMC3036178__F1 Lymphotoxin and the immediate tumor necrosis factor (TNF) family TRAF3 RELB TNF TRAF2 LTBR PMC8883113__F6 Prognostic Value of the Developmental Gene FZD6 in Young Saudi Breast Cancer Patients: A Biomarkers Discovery and Cancer Inducers OncoScreen Approach APC LRP5 CCND1 LRP6 PMC2882741__F1 Schematic view of the GSL metabolism pathways GATC SMS GLA PMC4045475__F1 MUC1: A Novel Metabolic Master Regulator MUC1 TIGAR TSC2 TSC1 MDM2 GLS2 FAT1 CD36 PMC9409325__F8 Tumor Necrosis Factor-Alpha-Induced C-C Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NFKB Pathway in Human Cardiac Fibroblasts EGFR CCL20 TNF PMC4045475__F3 MUC1: A Novel Metabolic Master Regulator MUC1 GPX1 GLS2 HEL-S-44 FAT1 HEL-S-133P CD36 PMC11931058__F8 Distribution of key targets in the most relevant pathways TH CD14 EGF PIN1 EGR1 TRADD FLNA GCK TNF NLK MAX MMP2 CDK4 TRAF2 MEF2C SELE TF STAT3 PMC3724940__F5 Transcriptomic Analysis of Insulin-Sensitive Tissues from Anti-Diabetic Drug Treated ZDF Rats, a T2DM Animal Model HADHB VPS72 IPO5 COX7A2 COX5A CXCL13 NDUFB8 NDUFA13 ENY2 MRPS12 CCL19 MRPL34 COX6A1 FUNDC2 NDUFB6 CHCHD2 NDUFS8 CHCHD6 COX8A UQCRQ CHCHD10 ACTR8 NDUFS6 CHCHD4 NDUFB2 NDUFAB1 NDUFS3 IDH3B COX6A2 UQCRH NDUFB7 CYC1 CXCL12 SOX6 CLIC4 PMC4602285__F7 The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease CASP3 APAF1 PTEN PMC6278438__F4 pathway of miRNA processing to regulate mRNA decay AGO2 DGCR8 MDC1 DROSHA PMC8156356__F2 Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function RELA MTOR FADD STAT3 BAX PMC3135880__F5 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell IGF1R IGF1 NGF PLG HEL-S-11 CCND1 GDNF BDNF PCNA PMC8046396__F2 PPI network of HT consists of 43 nodes, 234 edges, an average node degree of 17, and a high-confidence interaction (0.7; ) NUMB E2F4 INS MYC RB1 CDKN2A ADAM17 CCND2 HES1 CCNE1 CCND1 APOE RBL2 RBL1 ADIPOR1 ADIPOR2 ANGPTL4 CDKN1B IL6 TNF CDKN1C PRL RXRA LEP IGF1 CDKN1A CDKN2B ITGAV PPARG PCNA PMC4417587__F1 Metabolic pathways associated with 5-HT TPH1 ALDH3A2 TPH2 MAOA AADAT IDO2 AANAT TDO2 ASMT IDO1 HAAO INMT KYNU DDC KMO AFMID ALDH2 PMC7359717__F1 Synthesis and release of ACh by tuft cells PLCB2 ChAT GNAT3 TRPM5 ACHE BCHE PMC4123572__F6 Putative inhibitory pathway of the Cp-BF-mediated anti-inflammatory response TLR4 SRC TRAF6 SYK MYD88 TLR3 PMC11009220__F2 Interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health TBK1 TLR7 IRF7 TRAF6 IRF3 MYD88 ACE2 MAVS PMC2828612__F1 Putative mechanism by which the UPS acts downstream of BDNF/TrkB signaling to ultimately regulate Alpha-synuclein aggregation BDNF FADD PMC8834953__F3 Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives NLRP3 HMGB1 IL1B PMC8566112__F4 Peroxisomal biogenesis pathway PEX19 PEX6 PEX5 PEX10 PEX12 PEX16 PEX3 PEX13 PEX14 PMC8566112__F5 Peroxisomal Beta-oxidation pathway ABCD3 ABCD2 ACOX1 PMC8566112__F6 Ether lipid synthetic pathway GNPAT DHRS7B FAR1 LPA PMC8080614__F1 Glutamine metabolic pathways HEL-S-26 GOT2 GPT2 ASNS GLS2 GLUD1 CP PMC12102898__F5 Diverse E3 ligases participate in the modulation of multiple signaling pathways via the ubiquitination process, playing crucial roles in either immunological activation or immune evasion through specific mechanisms TBK1 TH CNOT4 MARCHF3 TRIM21 PARP1 CDK6 NBR1 BCLAF1 TRIM32 CDK4 SPOP STAT3 PMC12102898__F3 NFKB signaling pathway processes and associated ubiquitination PLCG1 TRADD GRAMD4 IRAK1 RELB TRAF3 TRAF6 PLCG2 MYD88 BCL10 BCR TRAF5 CD40 TRAF2 LTBR ITCH PMC5923348__F3 Intricate relationship between CD30 and AP-1 in Classical Hodgkin Lymphoma (CHL) and Anaplastic Large Cell Lymphoma (ALCL) TRAF3 JUNB TRAF2 BATF PMC5877576__F11 EGFR multimerization and signaling, illustrating how carbohydrate-binding proteins or carbohydrate-transferases can directly affect transmembrane receptor signal transduction MUC1 EGF EGFR PMC12102898__F4 HBV virus structure and related immune ubiquitination process involving HBx protein HMMR APC TRAF6 UHRF2 TRIM29 NEDD4 PMC12102898__F1 PI3K/Akt and Ras/MAPK signaling pathway processes and associated ubiquitination TSC1 TRIM71 GRB2 TRAF6 SPOP PTEN FBXW7 BRCA1 RHEB NEDD4 PMC12102898__F2 Wnt/Beta-catenin signaling pathway processes and associated ubiquitination RNF43 APC AXIN1 RNF146 TRIM65 PMC6566956__F2A Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells ELF2 ATF4 EIF2A PMC8978805__F2 Impact of anti-inflammatory agents on oncogenic pathways COX1 YAP1 GSK3B MYC CREB1 MTOR TSLP DNMT3B IL12RB1 TET2 TET1 COX2 CIP2A CRLF2 CXCR4 MCL1 EZH2 CXCL12 SETD2 STAT3 PMC7904157__F5 SlKLUH expression is associated with genes involved in ‘Cutin synthesis and transport’ pathway HEL-S-15 PMC10458925__F1 EGFR/PI3K/AKT/mTOR signaling pathway TSC2 TSC1 EGFR PTEN DEPTOR RHEB PMC5551366__F12 Mitogen-activated protein kinase signaling pathway NF1 CD14 NLK MOS MAX FLNA ECSIT TNF PMC3534167__F2 Hodgkin lymphoma NFKBIA CYLD RELB CD40 REL TNFAIP3 NFKBIE PMC8509779__F1 Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways TH VCAM1 APC CD80 TNF ACE2 STAT3 PMC8080614__F5 Glutamine oncometabolites and energy production from glutamine HEL-S-26 GOT2 KEAP1 FH TG HEL-S-32 MDH2 PMC10367567__F1 CXCL12-CXCR4/CXCR7 signaling pathway BAD APC CXCR4 CXCL12 PMC7792119__F9 Schematic diagram for the functions and mechanism of linc00887 in regulation of cervical cancer LATS1 LATS2 FRMD6 PMC3995293__F5 Oxidative Stress-Associated Protein Tyrosine Kinases and Phosphatases in Fanconi Anemia STAT1 ATM ATR IFNG PMC3209293__F6 IA30-infected pigs fail to induce immune response genes associated with pattern recognition of viruses and cytokine and immune cell responses in the lung IGF1R IRF7 CXCL10 IFNB1 MYD88 TNF TNLG7A CCR1 TYROBP TLR8 BTK LCP2 FCER1G PIK3AP1 BASH GBP2 KLRK1 CD40 SYK JAK3 IFIH1 PSME2 PMC4620423__F1 Core signaling pathways in embryonic stem cells and cancer stem cells NODAL FOS SMAD2 LIF APC SMAD4 BMI1 SUFU PTCH1 SMO CDC2 SMAD1 DKFZp781O1323 STAT3 PMC8481630__F7 BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NFKB Signaling Pathway Through Targeting TRAF2 TRADD BRCC3 TRAF2 FADD PMC12108521__F1 Molecular mechanisms of ferroptosis and key regulatory pathways GPX4 LPCAT3 STEAP3 FACL4 PMC3180440__F2 Regulation of the early myogenic transcriptional program by the kinome CDK2 CDK4 GIP CDC2 FOXO1 CDK6 PMC3180440__F3 Regulation of the late myogenic transcriptional program by the kinome PDK2 CDH2 MTOR CDK9 NFATC3 PMC5620322__F1 PRAS40 signaling in tumor TSC2 PIM1 IRS1 RHEB PMC6018527__F1 Sema4D/Plexin-B1 signaling ROCK2 PLCG1 LIMK1 SEMA4D ROCK1 ERBB2 GSK3B RRAS ARHA RAC1 RND1 PMC4871423__F6 Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression CXCR3 RUNX2 PPIG CCND1 MAP3K14 SIN3A MXI1 GATA2 PMC6636438__F2 Schematic model of ROS-activated signaling involved in the rapid modulation of NGB levels, its localization, and function on the redox balance outside mitochondria GCLM HMOX1 NQO1 NGB PMC5582379__F3 Five enriched pathways and their contributing DEGs are shown MYC CENPF SKA2 E2F3 UBC NUF2 POLE POLA2 CDK4 GINS2 CENPA RBL2 SPC25 AUP1 LIN9 GINS3 RCC2 CENPE MCM7 CENPL CENPK CENPO RFC3 RFC4 RFC2 CDC20 CDK2 SMC2 GINS4 DHFR TYMS CENPN SMC4 PCNA SKP2 PMC6032286__F1 Neuromuscular junction and congenital myasthenic syndromes ChAT DPAGT1 ACHE PREPL VAMP1 GFPT1 ALG2 MUSK COLQ LRP4 COL13A1 ALG14 SYT2 PMC7038066__F2 Proposed model of NO-dependent protein–protein interactions underlying GluA1 and GluA2 subunits’ trafficking CDK5 ARC BDNF PMC12245701__F2 TGFB inhibitors: the future for prevention and treatment of liver fibrosis? RHO MTOR PMC5084677__F8 Proposed model for the accumulation of BRCA1 complexes at DSB sites RNF168 RNF8 RIF1 BARD1 BRCA1 PMC4137413__F2 Genetics of Pulmonary Arterial Hypertension BMPR2 EIF2AK4 KCNK3 PMC9294386__F2 HIF-1A in Osteoarthritis: From Pathogenesis to Therapeutic Implications EPO BMP2 BNIP3 HMOX1 SOX9 PMC11103679__F1 Direct and indirect mechanisms of androgen signalling SRC TF PMC5486002__F1 The human 42 Kb INK4-ARF (CDKN2A/B) locus (not to scale) and its participation in two pathways controlling cell-cycling and differentiation MDM2 CDK4 CDK6 PMC4620694__F1 Graphical summary: DNA repair proteins such as DNA-PKcs can be targeted to improve outcomes for patients with ovarian cancer BAD PARP2 EMSY RAD51 PARP1 BRCA1 FANCF PMC5486002__F5 Examples of two pathways of histone modification by polycomb complexes leading to suppression of selected TSG PRC1 RBBP4 ATM DKK3 CDK4 BMI1 DKK1 DKK2 ATR DNMT3B SFRP5 PMC5564844__F1 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer EGFR GRB2 PMC9662188__F2 Caspase-2–dependent activation of de novo lipogenesis DHCR7 DHCR24 LDLR IL17RC CYP7A1 FASN PMC3460930__F1 Lovastatin Induces Multiple Stress Pathways TSC2 ATF4 EGFR EIF2A CCND1 ATF3 MTOR PMC9502459__F1 Do or Die: HPV E5, E6 and E7 in Cell Death Evasion BAD TRADD TRAF2 BAX PMC4344846__F2A IQGAPs choreograph cellular signaling from the membrane to the nucleus ZNRF3 APC GSK3B LRP5 IQGAP1 LRP6 RAN PMC5000066__F9 Proposed model illustrating how KLHL21 modulates the NFKB signaling pathway via targeting IKKB CXCL1 NFKBIZ KLHL21 TNFAIP3 IL1B PMC5747948__F9 Comprehensive molecular biomarker identification in breast cancer brain metastases PHLPP2 CSNK2A2 RPL22 FKBP3 PNN RPL23A RPL31 APLP1 FUNDC2 UFC1 CCNK NDUFS4 PRSS23 RPL13a RPL36 HEL-S-34 COXFA4 TAF1D CRTC3 COXFA4L3 TMEM223 MRPL40 LSM3 C3orf60 SLC25A6 SLC19A2 CPA3 PLRG1 GTF2H2C_2 MRPS24 PCDHB14 MLXIPL UGCG CWC15 TUBG1 HAUS2 MYL12B BANF1 HAUS1 HEL-S-66 ARMCX3 RPL27A PMC5747948__F6 Comprehensive molecular biomarker identification in breast cancer brain metastases RPLP2 LRCH2 RRAGD BLM TTK UBE2S RPS2 CEP72 SRC RAP1GAP DHRS3 DDT PFKP KNOP1 ESRP2 NUSAP1 CDON PLK2 LLGL2 SPRY4 MICU3 RASGRF1 CCNG1 DMBT1 GPR26 S100A7A CENPU EXOSC4 KNL1 GSDMB SMARCA1 EID1 PMC6650613__F1 Schematic representation of the steroidogenesis pathway CORT EPGN CYP17A1 PMC5747948__F7 Merged network based on eight upstream regulators, of which E2f, ERBB2, IL6, HGF, and RABL6 were in a predicted activation state (z-score > 2) and let-7, TP53, and CDKN2A were in a predicted inhibition state (z-score < - 2) C5orf22 PCLAF LY86 POLR3GL PPFIBP1 BLM TTK LRP8 CDKN2A S100A7 CEBPB RABL6 NR1i1 SSPN DRAM1 DTYMK KITLG RAD51 KIF15 CCNE2 NUSAP1 PLK2 CKS2 KIF24 ANGPTL4 BRIP1 NR3C1 WASF3 RARRES2 CDCP1 RFC4 ZNF655 H1-0 GJA1 ERBB2 WDR76 CCNG1 ORC1L BNIP3 PMC5097364__F4 T3-actions from genomic and non-genomic effects on cell adhesion and differentiation during vertebrate development STAT1 APC RAC1 PMC5747948__F5 Top canonical pathway is entitled, role of BRCA1 in DNA damage response NBAS ATM TOPBP1 ATRIP MDC1 BARD1 MSH2 ATR PMC11976366__F6 Quercetin inhibits gefitinib-activated cell death in NSCLC via regulating SHP2/ROS/AMPK/XBP-1/DJ-1 signaling pathway-mediated mitochondrial autophagy NLRP3 CGAS IRF3 PMC5097364__F2 Signaling pathways involved in cell-cell adhesion mediated by E-cadherin in physiological and pathological conditions STS APC RHO OTP KIFC3 CP PMC7246474__F2 Summary of proposed pathogenic mechanisms in TRAPS RIPK1 TRADD TRAF5 TNF TRAF2 PMC8899988__F8 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway KIF18A TUBA1B SP1 PMC3747576__F6 Urokinase pathway model PLAT PLG PMC3825115__F1 Notch pathway effects on cytoskeletal plasticity TH NUMB TUB PMC11881735__F7 Epigenetic regulation of NFKB and JAK/STAT signaling pathway in SAH IL10 SOCS3 HDAC3 VCAM1 KLF4 TRAF6 MYD88 EZH2 STAT3 PMC5564844__F4 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer EGFR PTEN STAT3 PMC8919722__F8 PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂ CXCL1 DAP UNK CCL2 TNF PMC12139130__F2 An overview of mechanisms of how gut microbiota increases the efficiency of immunotherapies CGAS TLR4 TLR9 IRF7 RGMB MTOR IFNG PMC11837068__F7 Schematic diagram illustrating that lncRNA H19 positively regulates S1PR3 expression by disrupting HDAC2/H3K27ac binding in EPCs HDAC2 S1PR3 PMC12139130__F1 Gut microbiota modulation in cancer metabolic reprogramming TIGAR BAD RELA FFAR2 PMC7432326__F1 Mode of 70-kDa heat shock protein (Hsp70) action inside and outside the cell TLR4 BCR APC FOXP3 PMC2174913__F2 Checkpoints activated upon rereplication FANCD2 RAD17 ATM CDK2 ATRIP CDC2 ATR BRCA1 PMC3308137__F2 miRNAs that promote or inhibit tumorigenesis provide diverse functions within oncogenic and tumor suppressor signaling pathways LIN28B MYC CDC27 SPRY1 CARD10 PTEN SPRY2 CCND2 CCNE2 PMC9354928__F11 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma STAT1 NF1 BRAF GRB2 CDKN2A ARAF PMC7998272__F3 Alternate splicing of the LOXL2 mRNA LOXL2 SRC HIF1A PMC4098619__F1 Schematic diagram representation of some of the pathways regulated by HNF1a PDX1 CREBBP SLC2A2 PCBD2 PCBD1 PMC5653694__F1 Circadian rhythms are driven by a vast network of oscillators regulated by multiple interconnected feedback loops that, in turn, synchronize the entire organism MPO REST ARC PMC2989866__F2 The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review HEL-S-62p CD59 FH CR1 PMC8051073__F4 Ingenuity Pathway Analysis (IPA), prediction network of the T1DM conditions presented in this study with the upregulation (red) of miR-126-5p, IL-7, TNFA, VEGF-C, CXCR1, CXCR2 and glucose CXCR1 VEGFC CELA2A IL8RB CCL27 PMC4165197__F4 Action of recombinant bovine somatotropin (rBST) IGF1 GRB2 SHE PMC6966813__F3 Ubiquitination on mTOR signal affects the cross-talk between RAS-RAF-MEK and PI3K-AKT-mTOR pathways TSC2 RICTOR PDK2 TRAF6 MTOR FBXW7 RHEB PMC2728430__F1 How ERK1/2 Activation Controls Cell Proliferation and Cell Death Is Subcellular Localization the Answer? FOS GRB2 PMC7596389__F10 Probable protective mechanism of UDCA against As(III)-mediated cytotoxicity in vivo and vitro NQO1 BAX PMC3782845__F4 Possible origin of WM precursors from IgM+ memory cells CD27 GC CD19 PMC3782845__F5 MYD88—an intriguing link between WM and natural effector IgM+ memory cells TLR8 TLR5 TLR7 TLR4 TLR9 CD27 IRAK1 TRAF6 IRAK4 MYD88 TIRAP PMC1899305__F7 GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS CD14 IRAK1 TRAF6 MYD88 TIRAP MAL PMC3110886__F4 Functional analyses of differentially expressed predicted targets of significantly altered microRNAs MADD ARHA CP RPS24 PMC4316180__F3 Tumor necrosis factor (TNF) induced apoptosis pathway and the Fas-Fas ligand-mediated apoptosis pathway TRADD TNF TRAF2 FADD PMC3090136__F1 Prostanoid biosynthesis and response pathway COX2 COX1 PMC4425560__F7 Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway MMP2 MMP9 CCND1 STAT3 PMC8351877__F4 Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy CXCR3 BOC RUNX3 SOCS3 STAT4 IL27 NFIL3 CD40 HEL-S-92n GATA3 IFNG STAT3 PMC3146625__F1 Schematic overview of the steroidogenic pathway AMACR AKR1C1 CYP11A1 UGT2B17 HSD17B2 AKR1C2 UGT2B15 HSD3B2 HSD17B3 HSD17B4 CYP17A1 STAR FASN PMC4962007__F3 Willin, merlin and ezrin are all FERM containing proteins that can influence proper functioning of the cytoskeleton, cell to cell junction complexes (TJ: tight junctions, AJ: adherens junctions) and the hippo signalling pathway LATS1 LATS2 PMC5222873__F4 Nuclear factor Y controls flowering time HEL-S-62p CRY1 C9 AGA CRY2 PMC7389684__F10 Schematic illustration depicting a proposed model of the molecular mechanism of PVT1 in gemcitabine resistance in human pancreatic cancer PYGO2 AGO2 ATG14 PMC3682205__F3 Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair TSC2 TSC1 PTEN MTOR RHEB NEDD4 PMC6612148__F3 CK2 actions on chaperone machinery (a), NFKB signaling (b), and PI3K/AKT/PTEN pathway (c) NOTCH1 CDC37 PTEN PMC9014248__F3 USP13: Multiple Functions and Target Inhibition ATM CDK2 TOPBP1 UBL4A BAG6 SGTA OGDH ACLY VCP ATR ATG14 BRCA1 PMC6445872__F2 In monocytes/macrophages and adipocytes, SIRT1 deacetylates NFKB(p65), resulting in reduced expression of inflammatory mediators such as TNFA and MCP-1 HEL-S-11 MTOR IRS1 SIRT1 PMC6445872__F5 SIRT6 also attenuates NFKB signaling via histone H3K9 deacetylation at the chromatin level SIRT6 STAT3 PMC10539544__F1 GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis PIG59 GLA SLC38A1 BAX GLS PMC4019409__F2 Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease SIRT2 TRADD RAC1 FADD ROS1 PMC2696318__F3 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAD BRAF FOXO3A MDM2 GRB2 PTEN MTOR PMC7685642__F2 miRNAsis involved in up-regulation of the bladder cancer PTEN DEPTOR PMC2696318__F4 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAD ATM MDM2 GRB2 SRC HBEGF ATR BAX PMC7685642__F3 Resveratrol, curcumin and paclitaxol affects the mTOR pathway at several stages from inhibition to PI3K to suppression of Akt signaling to prevent the mTORC1 and mTORC2 complexes TSC2 TSC1 PTEN MTOR DEPTOR RHEB PMC7355854__F1 Simplified scheme of the L-arginine/nitric oxide (NO) pathway HEL-S-277 ARG2 NOS2 ARG1 ASL PMC7056575__F1 Signaling via the PI3K pathway and inhibition of PGE2 production by NSAIDs TSC2 BAD TSC1 GSK3B PTEN PMC2696318__F5 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE DUSP5 MDM2 HBEGF PTEN ATR PMC7685642__F1 MTOR signaling cascade TSC2 RICTOR TSC1 RHO PTEN EIF4E MTOR RHOB PMC2696318__F6 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE MDM2 CDK4 PTEN CDK6 PMC2696318__F7 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAD GRB2 SRC PTEN MTOR PMC6360145__F3 Her2 signaling pathway in breast cancers GRB2 NRG2 PDPK1 PMC5725018__F6 Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway LEF1 PMC6568219__F1 Novel insights into cell cycle regulation of cell fate determination ATM SMAD2 CDK4 CDK6 PMC5693256__F2A DNA repair after oxidative stress: current challenges PARP1 OGG1 PMC11794540__F8 The mechanism by which endothelium-derived AGGF1 attenuates ischaemic retinopathy CCNA2 CCND1 TNFSF12 AGGF1 CDC2 PMC1895816__F2 Identification of a Bcr-Abl kinase signature VASP BCR GSK3B CDK3 HIPK1 CD2AP DYRK1A PMC6346557__F7 1A,25(OH)2D3 attenuates Il-6 and IL-1Beta-mediated inflammatory responses in MacCM-stimulated human white preadipocytes IL16 RELA IL6 PMC99889__F13 Erk activation following TCR stimulation ZAP70 GRB2 LAT PMC8114918__F6 Schematic figure showing the possible contribution of miR-506 to phenotypic presentation of colitis in patients with PSC + UC compared to those with UC alone SPHK1 PMC4767244__F2 NFKB activation pathways ATM RELB CD40 ATR LTBR PMC4767244__F3 NFKB signaling by oncogenic pathways in GBM ING4 NF1 ATM CYLD EGFR PTEN PMC6889380__F2 Haem synthesis pathway FECH UROD UROS ABCG2 PMC5214729__F4 Proposed renoprotective mechanisms in diabetic nephropathy (DN) through adenosine monophosphate-activated protein kinase (AMPK) activation TSC2 NRF1 MTOR STRADA HMGCR PMC8431402__F10 Comparison of the Effects of Resveratrol and Its Derivatives on the Radiation Response of MCF-7 Breast Cancer Cells FADD BAX PMC10685161__F2 Role of AGR2 as a critical regulator of maintaining intestinal barrier function by affecting the intestinal goblet cell differentiation, maturation, and secretion of MUC2 EGF ATOH1 EGFR SPDEF HEL-S-116 GFI1 MUC2 PMC10685161__F3 Effect of UPR-AGR2 signaling pathways on goblet cells during ETEC infection EGFR HEL-S-116 MUC2 PMC7648344__F1 Activation of MET pathway: pleiotropic effects on cancers through activation of a number of signaling pathways BAD HGF MDM2 GRB2 SRC MTOR STAT3 PMC10685161__F1 Major UPR pathways initiated from the ER and the potential role of AGR2 in interacting with EGFR and MUC2 ATF4 EGFR EIF2A HEL-S-116 MUC2 TRAF2 XBP1 PMC5412772__F1 TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different TRADD PROC CASP8 FADD MLKL PMC9478857__F2 Bronchial smooth muscle cell in asthma: where does it fit? ARHA RAC1 PMC7379270__F3 The mTORC1 pathway TSC2 ULK1 TSC1 ATF4 TRAF6 DEPTOR RHEB MLST8 PMC7379270__F4 The NF‐KB pathway NGF TRADD TRAF5 RELA TNF TRAF2 PMC8619803__F1 Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair PML FANCD2 BLM SLX4 TOP3A PARP1 MRE11A ZRANB3 RFC1 HEL-S-26 HLTF SMARCAL1 FANCM RAD52 KDM4B DNA2 PCNA PMC11829435__F7 Proposed model showing the mechanism of combined HDAC and FLT3 inhibition NOG WEE1 ATM CD34 RAD51 FLT3 PMC4303322__F4 The mammalian DNA damage checkpoint pathways and/or systems RAD17 ATM TOPBP1 HUS1 ATRIP MDC1 ATR BRCA1 PMC7703541__F2 Targeting the renin−angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges MAS1 AGTR1 MRGPRD ACE2 AGTR2 PMC8072221__F12 Expressional and Prognostic Value of S100A16 in Pancreatic Cancer Via Integrated Bioinformatics Analyses CS NUP214 RAB25 LZTS1 RBM42 DLAT VMA21 ACADM SDHA ACAT2 PMC3114474__F1 Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer HGF ERBB3 EGFR PMC7094289__F1 TLR signalling - TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10 are expressed on the surface of the cell whereas TLR3, TLR7, TLR8 and TLR9 in intracellular vesicles like endosome and lysosomes IRF7 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC11012314__F7 Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis EGF PRCC CTSK ELOC VEGFA VHL COL21A1 HIF1A RBX1 BIRC7 EGLN1 CADM2 EGLN3 CREBBP TFEB EP300 CDKN1A FH DVL2 EGLN2 TGFA TGFB1 PMC9031790__F3 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents BAD EIF2A BAX PMC6849114__F6 De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry NOTCH1 NOTO MCIDAS FOXJ1 CCNO PMC9316401__F1 Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University SOCS3 STAT3 PMC9499815__F8 Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism TSG101 USP14 ARHA HEL-S-133P HK2 PMC11843251__F11 Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis GPX4 FACL4 METRNL PMC8304079__F1 CAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling CCK NALCN GHSR GIPR GIP TRPM2 NACA TRPM5 SSTR2 VIP OXR1 PMC3970352__F2 Metabolic pathway of Inflammatory Response in humans TH APC PMC8572812__F3 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases IGF1 JAK1 MTOR STAT3 PMC9086828__F3 Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets BACE1 ADIPOR1 CCL5 CD36 PMC9549314__F7 We are all aging, and here's why PPA2 GRB2 PTEN PMC4917523__F4 Schematic representation of the interplay between the IGF1 signaling axis and p53 genome protection pathway IGF1R IGF1 IGF2 MDM2 PMC8917441__F7 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis APP MOK HEL-S-87p TF PMC2696318__F1 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE GRB2 SHE BAX PMC8917441__F8 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis CAST APP CAD FADD TARP PMC8811717__F4 Integrated Stress Response, Drug Targets, and Drugs ELF2 NUPR1 ATF4 GSK3B TRIB3 ATF3 XBP1 PMC8572812__F1 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases PTEN JAK1 MTOR INSR STAT3 PMC8572812__F2 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases IGF1 MTOR ARG1 STAT3 PMC9124632__F1 Type-I interferons in the immunopathogenesis and treatment of Coronavirus disease 2019 TBK1 CGAS TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 NOD2 TLR3 TLR8 TLR7 TLR4 TYK2 JAK1 MAVS PMC9031790__F2 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents ATF4 XBP1 PMC9110208__F9 Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway CTSK KEAP1 NFATC1 MMP9 TRAF6 MTOR PMC7460314__F2 Key pathway of adipose metabolism LPL TG HEL-S-104 NR1C1 HEL-S-5 PMC6555193__F4 Cancer pathway gene set targeted only by natural products for a cancer driver target E2F8 ARID3A CCNA2 E2F7 CDKN1A CDK2 CDKN1B CCNE2 CCNE1 PMC1564204__F6 Schematic pathway of lipid turnover induced by Pi stress PC HEL-S-44 PMC3226388__F3 Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway TSC2 EEF2K TSC1 EIF4E RPS6 MTOR EIF4B RHEB PMC2844927__F3 Routes of interaction between epoxyeicosanoid and endocannabinoid signaling pathways TRPV4 FAAH TRPV1 PMC10536747__F2 Liver and Muscle Transcriptomes Differ in Mid-Lactation Cows Divergent in Feed Efficiency in the Presence or Absence of Supplemental Rumen-Protected Choline SCD LPIN1 NR1C2 PRKAG2 MAP2K3 HK2 PMC8866688__F1 Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle? HEL-S-102 UBE2G2 HEL-S-94n STUB1 MAPKAPK5 DNAJB1 PMC10525531__F7 High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis GPX4 STAT3 PMC10745682__F2 Potential association between the ER stress signaling pathway and obesity ATF4 EIF2A XBP1 IRS1 PMC2801237__F5 Proposed revised model of mammalian DNA damage response RNF8 ATM MDC1 RAD50 ATR H2AX MRE11A BRCA1 PMC3170087__F2 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity TLR3 IFNG PMC3381108__F2 Unfolded protein response (UPR) CASP3 ATF4 EIF2A TRAF2 XBP1 BAX PMC84049__F9 Control of LHB gene expression by Egr-1, Ptx1, and SF-1 GNRHR EGR1 PMC6423962__F1 Expanded cholesterol synthesis pathway diagram SQLE LBR DHCR7 EBP SC5D DHCR24 HSD17B7 TM7SF2 HMGCR PMC6923311__F4 Homology-directed repair pathway determination and its favorable cell contexts WEE1 RAD50 MRE11A PMC6923311__F1 DSB repair pathways.1017In the C-NHEJ pathway, DSB formation induces binding to broken ends by KU70/80 heterodimers that subsequently recruit the DNA damage response kinase (DDK) complex such as DNA-PKcs in mammals FEN1 RIF1 ATM GC H2AX DNA2 BRCA1 PMC6079365__F2 Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance TLR4 MYD88 IL1B PMC3353643__F6 Proposed model of WNK4 signaling pathway mediating NCC regulation in DCT WNK1 DCT OSR1 WNK4 SGK1 PMC8125460__F2 From Channels to Canonical Wnt Signaling: A Pathological Perspective AQP1 APC GSK3B MYC AXIN1 PMC9232569__F7 Targeting signaling pathways in prostate cancer: mechanisms and clinical trials RNF43 APC GSK3B ROR1 PMC5310573__F5 Estrogen metabolism pathway including enzymes (blue field) and chemical compounds STS HSD3B1 HSD17B1 HSD17B2 HSD17B7 HSD17B3 HSD17B4 HSD17B10 PMC4867368__F12 Comparison of the lipoate assembly pathways of E LIPM LIPA PMC8647428__F1 Osteochondroma Pathogenesis IHH WNT4 PTCH1 LRP5 SHH LRP6 WNT2B SMAD1 DKFZp781O1323 FZD8 PMC3412587__F1 Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML) NF1 ASXL1 GRB2 SOS1 CBL PMC8047216__F1 Stem cell migration CXCR3 EPO CCR3 CXCR4 CCR4 BDNF CXCL11 PMC6072433__F6 Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids CYP2E1 DNAJC1 PMC6072433__F4 APAP-sensitive proteins related to protein synthesis PIG59 CLDN1 EEF2 MAPK3 CAND1 SKP1 RPL4 RPS11 TMED7 CACYBP RPL12 EIF3B HEL-S-100n RPS3 PMC4981742__F1 Mitochondrial dysfunction in gliomas- Evasion of Apoptosis: Impaired mitochondrial function due to the genomic mutations in mtDNA leads to impaired function of electron transport chain thus enhancing generation of ROS EGF APAF1 MDM2 MTOR BAX PMC11076710__F9 Nrf2/ARE signaling pathway, mitochondrial ROS, and NLRP3 inflammasome in renal tubular epithelial cells under high lipid conditions NLRP3 KEAP1 NQO1 PMC8272378__F2 Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis LIAS TOMT PDK2 DLD ACSS2 AASS HIF1A DBT IDH3B RPL15 NDUFV3 GLDC SUCLA2 OGDH AMT HEL-S-281 GCSH PXMP2 PMC7466429__F2 Signaling pathways activated by catecholamines MYC MDM2 USP28 HEL-S-133P STAT3 PMC7466429__F3 Stress hormones on the immune system COX2 APC TNF PMC7596389__F9 Schematic presentation probable protective mechanism of Ursodeoxycholic acid (UDCA) against As(III)-mediated hepatic injury by activating the Nrf2 pathway CASP3 KEAP1 NFE2L2 CASP9 BCL2 HEL-S-44 GPX8 HMOX1 NQO1 CYCS BAX PMC6116077__F3 Interferon pathway STAT1 STAT2 IRF9 TYK2 JAK1 IFNG PMC2696566__F1 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy IGF1R SRC RHO PTEN HRAS MTOR MEF2C IRS1 CDC42 PMC2696566__F2 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy ATM PARP1 ATR PMC10968558__F6 Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review GSTA4 ATXN3 GCLC NFE2L2 BCL2L1 HSF1 HMOX1 SYT1 NQO1 HEL-S-22 PLCB4 PPARGC1A HEL-S-44 HEL-S-72p CYCS BAX PMC8389183__F5 Recent ecophysiological, biochemical and evolutional insights into plant carnivory KIN TF PMC5297839__F1 Phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR), retrovirus-associated DNA sequences/mitogen activated protein kinase (RAS/MAPK) pathways and c-MYC are master regulators of cell growth and proliferation PTEN EIF4E RPS6 POLI PMC10968558__F2 Mitochondrial dysfunction in the pathogenesis of SCA3 ATXN3 BCL2 CYCS BAX PMC8552808__F3 Treatment of COVID-19 with Traditional Chinese Medicine: What Herbs Can Help Win the Battle with SARS-CoV-2? APC TNF PMC10968558__F3 Alteration of DNA damage response in the pathogenesis of SCA3 ATM PMAIP1 MDC1 ATR CHEK1 PNKP BAX PMC9288037__F1 Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents PDE4D TUBB6 SELENOW EGFR MYC HEL-S-116 PTEN HEL-S-104 RAB15 KLK11 TUBA2 PC MMP2 NINJ2 MYBL2 STXBP4 NONO TP63 PARP1 LMNA FUS TUBB4B GJA1 ERBB2 CDK2 RELA BCL2 HEL113 HEL-S-93 TUBB4A PCNA TERT PMC6854373__F8 Graphical abstract of how EGFR signaling pathway and downstream effector inhibit the miR-124a expression and the role of ETS2 in insulin production in pancreatic beta cells PDX1 ETS2 FOXA2 PMC2923715__F5 Wnt signaling pathways ARHA NPHP3 PMC8027424__F1 Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping CS FH POR HEL107 RPE PMC7923692__F1 RPTOR BioID2 reveals spatial association between mTORC1 and FAs PIK3CD ASAP1 TLR9 AP2A2 ETV6 SEH1L GSK3B MYC AKT1S1 PRKAA1 DNAJB1 PHACTR4 ARL8A CUL7 CEP192 LAMTOR2 SRC HEL-S-44 CSNK1A1 CALD1 VPS35 ARHGEF7 VPS13D AKR1B1 EIF4E DEPTOR IRS1 SNAP23 RHEB MLST8 TSC2 RICTOR TSC1 ARPC2 LAMTOR1 GNAI3 GRB2 PPP2CA TNS1 SLC3A2 RRAGA NAPG TBKBP1 IGF2R RRAGD EIF4EBP2 SQSTM1 PEAK1 LAMTOR3 TLN1 ANXA6 EIF4EBP1 MTOR KANK2 PARVA HEL-S-128m RSU1 LIMD1 RPTOR EML4 MAJN TNS3 LPP RPS6 EIF4B CGN INPPL1 ANXA1 ARHA HAX1 CAB39 TCIRG1 MAPKAP1 PIK3R4 LIMS1 IKBKB TTI1 CARD11 RPS6KB1 EIF3F AP2S1 LYN PIK3CA RAB3GAP1 GRB10 VAMP8 PXN PMC3012004__F2 Sites of action for inhibitors and shRNAs in the EGFR-PI3K-Akt-mTOR pathway TSC2 RICTOR TSC1 EGFR PTEN MTOR IRS1 PMC8005514__F3 PI3K/AKT pathway and HER2-targeted therapy resistance IGF1R MUC4 PTEN MTOR PMC8005514__F4 PI3K/AKT pathway is related to chemotherapy, CDK4/6 and PARP inhibitor resistance KEAP1 GSK3B SSB SRC CDK4 PTEN MTOR CDK6 PMC8005514__F1 PI3K/AKT signaling pathway in breast cancer BAD PTEN PMC3012004__F1 PI3 kinase signaling pathway in glioma TSC2 RICTOR BAD TSC1 IGF1R EGFR GSK3B CCND1 PTEN MTOR PMC2928642__F8 The PA-mediated activation of mTORC1 signaling TSC2 TSC1 PC LPA RHEB PMC10239497__F10 Dissecting specific Wnt components governing osteogenic differentiation potential by human periodontal ligament stem cells through interleukin-6 APC LRP5 LRP6 FRAT1 PMC6643108__F5 Relation graph of KEGG pathways in which differentially expressed genes were significantly enriched MAPK9 FOS PCNA LAMC2 CCNE2 PMC4241130__F2 Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach ACAN ACADM HEL-S-5 PMC8503815__F2 Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer CASP3 BAD ATF4 CASP9 PTEN BAX PMC3877975__F5 Coordinately up-regulated genes of chemokine signaling pathway in monocytes from the VIR group (VIR versus BDL) GRB2 SHE ARHA DOCK2 PMC5342747__F5 Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells EGF IGF1R IGF1 EGFR PMC8136775__F1 Untangling the crosstalk between BRCA1 and R-loops during DNA repair PALB2 BLM BRCA2 RAD52 RAD51 PARP1 DNA2 PMC3976145__F1 Genes involved in the WNT signaling pathway APC TEF LRP5 LRP6 PMC8156432__F8 Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFB1 Secretion through the AKT Signaling Pathway TGFB1 ORAI1 STIM1 PMC3826118__F1 Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in carinogenesis COX2 CASR NR1i1 CYP24A1 TCF4 PMC7916216__F2 Direct and indirect effects of radiotherapy, chemotherapy, and protein kinase inhibitors on NK cell activity CXCL16 ULBP2 HLA-G BRAF GSK3B MICA PMC7882494__F7 Pathway analysis PIK3R1 IGF1R BRAF DKK3 SMAD2 IGF2 TGFBR1 APC ERBB3 TGFBR2 NRAS MYC SMAD4 PTEN DKK4 CHEK2 ACVR2A ATM ERBB2 AXIN2 PMC8282181__F3 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum GRB2 MTOR FOXO1 CBL PMC8282181__F4 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum GRB2 TNF TRAF2 CDC42 PMC7669714__F3 DNA replication restart pathway choice REV1 POLK PRIMPOL POLN PRIM1 PMC10503159__F9 Proposed model depicting the possible mechanism of bta-miR-223 on mediating inflammatory injuries and oxidative stress via regulation of NLRP3 inflammasome and Keap1/Nrf2 pathway NLRP3 TLR4 KEAP1 PMC8122117__F4 Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets GPR55 MTOR MBOAT7 PMC4272512__F2 Immune, antioxidant and inflammatory targets that L-glutamine, L-arginine and BCAA are involved HEL-75 NOS2 MTOR HSF1 SIRT1 GLS PMC3705552__F2 TIR8/SIGIRR, a negative regulatory receptor of ILR and TLR signaling SIGIRR MYD88 MTOR PMC6441003__F7 Proposed model for the impact of Metformin on FOXO3a and gene transcription in primary human fibroblasts TSC2 IL1A TSC1 IL6 IL-21 RHEB PMC12081257__F1 Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression GCLM KEAP1 GCLC NQO1 PMC1186734__F6 Glucocorticoid Receptor-Dependent Gene Regulatory Networks E2F4 HLA-G HEL2 PCK1 MMP11 MYC GAS1 ONECUT1 TXN STAT1 MMP7 SMARCA4 PPARGC1A MAPK1 SERPINA1 NCOA1 ETS2 B2M FNTA HOXA5 NR1H3 ADM JUN APOA2 PSMB8 HSPA4 NR3C1 TNF NR1C1 EIF4G1 HLA-B HLA-C DBI CKS1B CASP3 NFKBIB HNF4A STUB1 RELA IGFBP1 YY1 ABCA1 PPARG BRD2 PMC8383365__F1 Pyroptosis at the forefront of anticancer immunity NLRP3 RIPK1 NLRP1 GSDMA RHO GSDMC AIM2 IL1B FADD GSDMB GSDMD DFNA5 PMC6833007__F1 Mechanisms involved in activation and regulation of NLRP3 canonical pathway SIRT2 IL16 EIF2AK2 MYD88 PMC7166547__F2 Innate immune response and adaptive immune responses of Coronaviruses (CoV) infection during an infection TLR4 IRF7 IRF3 IRAK4 MYD88 TLR3 TIRAP PMC7180609__F7 Glutamine-dependent metabolic pathways in T HAL PRODH PMC6383680__F6 Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 signaling cascades ATG16L1 NOD1 ATG12 TRAF5 UNK TRAF6 MAP3K7IP1 TRAF2 DKFZp686F0183 NOD2 TAB3 PMC6734087__F2 Canonical transforming growth factor (TGF)B and noncanonical pathways in endothelial to mesenchymal transition (EndMT) SNAI1 ACTA2 TWIST1 SMAD2 SNAI2 SMAD6 SMAD4 MTOR PMC6734087__F3 Diagrammatic representation of other pathways involved in endothelial to mesenchymal transition (EndMT) regulation SNAI1 ACTA2 SMAD2 SMAD4 NOX4 HIF1A PMC11520539__F3 Diagram illustrates the immune exchange pathway mediated by ADAR1, a dsRNA A-to-I editing transformation modulating enzyme LIN28B ADAR IL3RA PMC5968182__F1 Hypothetical roles of linear and circular ANRIL lncRNA in regulating inflammation and cell survival in human vascular endothelial cells and potential drug targets PES1 YY1 IL6 PMC6023503__F2 IPA pathway analysis, in which specific genes emerged throughout our review, are shown in purple TRIM52 HTT ZNF706 PMC7268359__F6 Schematic diagram of the mechanism of soyasaponins’ regulation on TLR4 signaling pathway CD14 IRAK1 LBP TRAF6 MYD88 IL1B TIRAP PMC6005741__F1 The force is strong with this one: Metabolism (over)powers stem cell fate VIT APC EGFR ACLY MTOR PMC5834423__F1 MicroRNAs (miRNAs) targeting insulin signaling mediators GRB2 IRS1 FOXO1 PMC5019081__F3 Wnt signaling pathways regulate gene expression and cell movements APC LRP5 LRP6 ARHA ROR2 RAC1 CDC42 PMC3717758__F3 Structure–activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease GGA1 APP APOE PMC7880430__F2 Finding branched pathways in metabolic network via atom group tracking DKFZp666G145 CR2 ACD CR1 PMC5344939__F1 Molecular mechanisms of PI3K-AKT-mTOR signaling cascade related neurodevelopmental diseases FOXG1 PTEN PMC2679770__F3 Proposed saxitoxin biosynthetic pathway STS PMC9466315__F4 Immune responses to Lassa virus TBK1 APC TRAF3 MYD88 TLR1 MAVS TIRAP PMC3390254__F1 An emerging role of mTOR in lipid biosynthesis TSC2 TSC1 MTOR DEPTOR SGK1 RHEB MLST8 PMC4151049__F2 Biochemical Signaling of PD-1 on T Cells and Its Functional Implications FYN CPT1A PTEN LAT PMC4859290__F7 Analysis of signaling pathways specific to base:apex comparison ELF2 MTOR RPS26 RPS16 ZNF183 PABPC1 RPS25 ELF3 RPS17 NDUFA11 RPS27 RPS6 RPS3 COX7B ELF4 NDUFS5 SDHD RPS21 SDHB UQCRQ RPS23 PMC8278124__F8 Astragalus polysaccharide attenuates LPS‐related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway TLR4 CTSK NFATC1 TRAF6 IL6 TRAF2 PMC9155915__F7 Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer's Disease Based on Network Pharmacology and Experimental Validation TSC2 BAD BCR GRB2 CYC1 RAC1 EIF4E GAL MTOR RHEB CD19 PMC6822174__F1 Cell metabolism FH ACLY FASN HEL-S-5 GLS PMC5343902__F2 Mammalian target of rapamycin (mTOR) pathway TSC2 EGF ULK1 TSC1 EGFR GRB2 PTEN RHEB PMC5451429__F8 Proposed model for the effects of GSK3B inhibitors on HCV virion particles’ assembly/release APOB GSK3B APOE PMC8914022__F1 Weighing in on Adipogenesis SIRT4 IVD MCCC1 GLS PMC3823580__F8 Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence CLC BCL2 EIF4E MTOR BAX PMC3992201__F2 Genes identified in GWAS of Phase 1+2 AA subjects using a case-control model in the canonical pathway “calcium signaling.” The gene or gene families with a significant association result are shown in orange HEL-S-99n CAD PMC2702844__F2 Cell biology of autophagy in metazoans: a developing story TSC2 TSC1 BCL2 RHEB PMC8656925__F1 Targeted Therapy in HR+ HER2− Metastatic Breast Cancer: Current Clinical Trials and Their Implications for CDK4/6 Inhibitor Therapy and beyond Treatment Options CDK4 MTOR CDK6 PMC9688771__F2 Sweet Warning: Mucin-Type O-Glycans in Cancer SRC GAL GBF1 PMC9192598__F2 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter CXCL1 EGR1 AKAP12 TFPI ANGPTL4 CFB MMP9 IL6 S100A9 MYH10 COCH SOX9 ITGA2 GBP1 THBS2 BIRC3 STK4 ABCA1 pk JUN IFI16 PMC9192598__F3 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter EREG PLAUR FOS LIF MMP9 IL1RN LCN2 IL24 HMOX1 TNC DCN IL18 TNFSF10 CYP1A1 CSF2 TGFA JUN SERPINB2 KRT10 PMC7052851__F1 Cholesterol biosynthesis pathway in cancer cells SQLE ACAT1 HMGCR ACAT2 PMC3278830__F3 Functions related to hepatic cultures.Subgraphs of a hepatocyte response network induced by genes annotated with MSigDB gene sets ITGA1 LOC51064 NR5A2 ANAPC2 NRAS RXRG RRAS2 ADH7 CHEK1 CYP2E1 MCM6 MGST1 HNF4A WEE1 ITGA6 PFN2 GSTM3 NR1H3 ACTN4 UGT2A1 PSMB8 PMC7235470__F1 Cytokine storm and stress can increase gut dysbiosis/permeability, further contributing to cytokine induced IDO and TDO, leading to kynurenine and kynurenic acid, which activate the AhR to increase CYP1B1 and regulate the NAS/Melatonin ratio ASMT PDC AHR CYP1B1 CYP2C19 AANAT PMC9181382__F4 Rethinking Sesquiterpenoids: A Widespread Hormone in Animals PMVK MVK HMGCR PMC9373414__F1 CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial APC NOTUM DKK2 WIF1 PMC1088000__F4 In Silico Analysis of the L F5 C7 HEL-S-5 PMC3131135__F1 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 PMC3131135__F2 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection IRF3 MAVS PMC7919196__F2 Pathogenesis of COVID-19, showing the involvement of components of the fibrinolytic system in various steps PLG ACE2 TMPRSS2 PMC3540170__F4 Immunoregulatory role of anchored cAMP signaling in T cells CD14 TLR4 LCK FOXP3 PMC3975429__F1 MAPK signalling cascades leading to MK5 activation PAK1 PMC5224989__F3 Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring TSC2 BAD GRB2 INS EIF4E MTOR RHEB INSR PMC5655190__F14 Sodium fluoride induces renal inflammatory responses by activating NFKB signaling pathway and reducing anti-inflammatory cytokine expression in mice IL10 IL4 IL1B PMC9635866__F6 Realgar-induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis GPX4 FACL4 PMC7862443__F2 Met1-Ub Machinery CYLD SHARPIN RING1 FAT10 OTULIN PMC7724447__F1 Role of statins and PCSK9 inhibitors in COVID-19 pathophysiology and complications PCSK9 LDLR MYD88 ACE2 PMC5562164__F3 Innate Immunity to Intracellular pathogens: balancing microbial elimination and inflammation HEL-S-62p ISG15 ULK1 ATG16L1 IL16 GAL PMC3877903__F9 Fumigaclavine C-induced apoptosis in MCF-7 breast cancer cells through the mitochondrial pathway BAD CDK2 CCNB1 BCL2 BAX PMC3996160__F6 A hypothetical model depicting the mechanisms used by SARS-CoV PLpro-TM to disrupt the STING-TRAF3-TBK1 complex required for activation of the IFNB production pathway TBK1 TRAF3 IRF3 MAVS PMC5841288__F9 Model of the Itch/Beta-arrestin2-dependent regulation of the SuFu/Gli3 complex function SUFU PTCH1 GLI3 SHH SMO ITCH PMC6217971__F3 Co-occurrence networks of diagnostic KOs involved in major energy and carbon fixation metabolic pathways in Llamara microbial mats from pond LLA9 SDHC SOX2 DERA DLD AADAT PDC COX2 COX3 HP COX11 NIFK SDHD SDHA SDHB PMC5853495__F7 Model for biosynthesis of sterols and other isoprenoids in rice roots DAP LPA IPP PMC6104109__F2 Canonical pathways of oxidative phosphorylation and mitochondrial dysfunction NDUFB2 NDUFS8 COX7A2 PMC1798432__F8 Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages TLR4 ATF2 IFNG PMC11006482__F9 Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice NLRP3 HADHB TNF SIRT1 PMC5311241__F9 A positive feedback loop from Snail to Cat L to CUX1 and back to Snail drives EMT and can be inhibited by Cat L inhibitor Nbla10317 PMC4484807__F6 Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome CD14 CTSK TLR9 CD6 TRAF6 IRAK4 IRF3 RAC1 MYD88 CPO PDC TLR4 LBP CD40 FADD TIRAP PMC4654299__F2 Regulation of endosomal trafficking RAB27A RAB22A RAB7B RAB27B ARF6 ARF1 PMC7911386__F2 Signaling pathways of obese/T2D cell, of critical COVID-19 cases NLRP3 TLR8 EGR1 TLR7 IRF7 IRAK2 CRP CCL2 MYD88 ACE2 IL1B BAX PMC4055129__F1 Inhibition mechanism of MTX in DNA synthesis pathway DHFR MTRR FPGS PMC8584169__F2 Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease CX3CR1 CX3CL1 BDNF PMC6967775__F1 Synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas EGF EGFR MTOR PMC7843454__F3 Peroxisomal and mitochondrial fatty acid oxidation are dysregulated in both early and late CKD ETFB ACADS GAA ETFA PMC6682659__F3 Molecular consequences of the PrPC/AB interaction in AD FYN ABO PMC7599912__F3 Metabolic Pi sensing in mammals (modified from ) IP6K1 CASR FRS2 GRB2 SPX PMC12116377__F2 Summary diagram illustrating PD-L1-related immune sensitivity and resistance mechanisms in GC HPD GC CD44 FOXP3 PMC7028128__F8 Proposed model linking the miR‐574‐5p locus to the biology of goat mammary epithelial cells (GMECs) EGF BAD MAP2 MAP2K4 EGFR MTOR MAP2K1 CCND1 RPS6 EIF4B JUN CDC42 AKT3 BAX PMC8718268__F4 Dynamics of Wnt signalling ZNRF3 RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC8453690__F2 Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke BAD MMP9 TNF BDNF BAX PMC6713433__F6 mRNA-miRNA-pathway regulatory network TNFSF8 GRK1 IL8RB IL12B PMC8835409__F5 Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers TAF9B PTEN FOXL2 BAX PMC2964873__F1 The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities HES6 SIAH2 HIF1A SOX9 PLOD2 FOXA2 PMC3848785__F3 Schematic diagram of the known PtdEtn biosynthetic pathways PSD2 PMC6769509__F3 Flavonoids as anti-diabetic agents: Modes of Action VEGFA PMC8388033__F4 Multi-layered network-based pathway activity inference using directed random walks: application to predicting clinical outcomes in urologic cancer ABCD3 PIG59 ABCC3 GNG13 FACL4 HAL MAPK3 ALOX15 HLA-DQB1 PYGB CDC34 PYGM HLA-DMA ACADS ABCC9 GNG2 ABCA4 IDUA NTRK2 CREB3L4 CDC23 STAT2 ABCG8 CHMP4C AIRE ACADSB PRPF19 GNG12 CALM1 ITGB7 FADS1 ACOX3 TGFB1 PYGL OXSM PMC8874859__F4 How RSV Proteins Join Forces to Overcome the Host Innate Immune Response TBK1 SOCS3 STAT2 IRF7 IFITM3 IRF9 TRAF3 IRF3 TRIM25 STAT1 OASL TYK2 JAK1 TF MAVS SOCS1 IFIT1 PMC6479799__F2 Mechanism of CB-R-mediated antitumor activity in breast cancer cells GPR55 SRC JUND ARHA MTOR PMC7294576__F9 Beta-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NFKB Signaling Pathways CD44 CDH2 BAX PMC2966480__F4 E3 ubiquitin ligase activities of KEAP1 and AHR AHR KEAP1 RBX1 PMC5504455__F10 Diagrammatic summary of the principal ways by which the Unfolded Protein Response pathway may interact with the mTOR/AKT pathway to modulate protein synthesis within the placenta EEF2 EIF2A EIF4E MTOR PMC3488210__F3 Sub-network found among the genes in a differential expression experiment that compares FA patients to controls MYB BAD ERG APC NPEPPS MTOR PMC3488210__F5 Significant sub-networks (see also ) found among the lists of most essential genes, ranked by the RIGER parameter, obtained for both cell lines: (A) Jurkat and (B) K562 MCCC2 LYAR RELB MYC HEL-S-47e VPS72 RPS7 YEATS4 XAB2 ATM RELA CNBP MBIP RPL7 PMC5776165__F1 MAPK signaling pathway, where each MAPK phosphorylates several transcriptional factors, regulating protein expression ATF2 MYC MEF2C AK1 MEF2D PMC3170087__F4 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity TRAF3 IRF3 FADD PMC4060077__F1 Molecular switching from apoptosis to necroptosis PGAM5 TNF FADD MLKL BAX PMC5937214__F7 Signaling pathways between palmitate and TNFA for CCL2 production TLR4 IRAK1 TRAF6 IRF3 CCL2 MYD88 TRAF2 CPZ PMC5393155__F10 Insulin receptor signaling pathways PTEN MTOR ELF4 IRS1 PMC8577797__F6 Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway PACS2 EGF EGFR EIF2A RHBDF2 ADAM17 STAT3 PMC3769702__F5 Pathway diagram of the CTLA4 signaling in cytotoxic T lymphocytes from the IPA PLCG1 FYN LCK GRB2 SYK CD80 CTLA4 LAT PMC3172806__F7 A model of pericyte-induced EC survival signaling VTN VEGFA PMC6121264__F6 Putative targets of down-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer and (B) PI3K-Akt pathway EGFR MYC GRB2 CTNNA1 RAC1 RHEB PMC9502483__F2 Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease NLRP3 TLR4 SCARB1 MMP9 CD36 PMC4687464__F2 Wilms' tumor 1 (WT1) contributes to metanephric mesenchyme self-renewal and its differentiation HOXD11 PAX2 WNT4 SALL1 BMPER WNT9B LHX1 BMP7 GAS1 WT1 SIX2 BMP4 PMC7465315__F1 Keratinization at a glance TGM3 TGM1 PMC5354742__F3 Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells PDE4D TRPV4 ALOX15 GATA6 PROK2 FGFR1 MMP2 NT5E PER2 NPPA GPHA2 RIIAD1 ITM2A PF4 PON1 NTS CD200 PDK4 tal-1 TDO2 NFATC2 IGF1 SLC2A4 ABCA1 ADRB3 CP PDE7B PMC6815045__F3 PI3K-Akt signaling pathway ME1 BAD MEI1 MYC CA3 PTEN RAC1 EIF4E MTOR RHEB RXRA TSC2 BCR GAB2 MDM2 SIPA1 CASP9 SYK EIF4B RBL2 CD19 PMC7700122__F2 Under normal homeostatic conditions, Keap1 homodimerizes through the N-terminal BTB domain and binds to the cullin-based (Cul3) E3 ligase, forming Keap1-Cul3-RBX1 (Ring box protein-1) E3 ligase complex, leading to Nrf2 ubiquitination and degradation GCLM KEAP1 RBX1 NQO1 PMC9672378__F1 Myeloid and lymphoid cell development by O-glycans on Notch MAML1 EGF DLL4 NOTCH1 ADAM10 PMC10035973__F6 RNA-seq and microRNA association analysis to explore the pathogenic mechanism of DHAV-1 infection with DEHs MFN2 BCL2L13 TRAF3 PMC8624316__F1 Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition TDG DNMT3B PMC7423897__F3 Overlap of identified miRNA targets with pathways related to the pathogenesis of atherosclerosis CCR2 TNFRSF14 CCR3 TNFRSF12A CXCR4 CD40 TF PMC9679015__F2 Polymerase D-interacting protein family and their emerging roles in diseases LIPT1 ECT2 CLPX CCND1 NOX4 ARHA CDH2 HIF1A TRPV1 PMC5090832__F1 JAK/STAT, Raf/MEK/ERK, and PI3K/PTEN/Akt/mTOR pathway cascades.In the JAK/STAT pathway, JAK2, which can be inhibited by AG490 and/or SOCS3, can phosphorylate STAT3 through downstream signalling SOCS3 PTEN MTOR STAT3 PMC5090832__F2 Proposed signaling mechanism underlying the neuroprotective role of tPA.tPA enters the cell where it indirectly activates cellular signaling mechanisms, including Janus kinase 2 (JAK2) and/or mammalian target of rapamycin (mTOR) MTOR STAT3 PMC7922220__F2 GnRH-II signaling in ovarian cancer cells assuming that a truncated GnRH-II receptor (A) or no GnRH-II receptor (B) exists EGF EGFR JUND BAX PMC7599984__F1 Wnt signaling pathway GSK3B LRP5 LRP6 PMC11206395__F3 Therapeutic mechanism of polyphenols for anxiety disorder IL11 BDNF PMC7922220__F1 GnRH-I receptor signaling in ovarian cancer cells EGF EGFR GRB2 SRC JUND PMC7599984__F3 TGFB family signaling pathway SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7599984__F4 Hedgehog signaling pathway BOC SUFU SMO PMC6503366__F5 “Cytokine–cytokine receptor interaction”, “steroid biosynthesis” and “cell cycle” pathway and the identified regulator EPOR EGF BMP6 CCNA2 EPO EGFR DHCR24 VEGFA TPO STAT1 AMH CDK2 PRLR CCNB2 CCNB1 CCND1 CDC2 SMAD1 PCNA DKFZp781O1323 PMC3362297__F11 Proposed roles of the calcineurin signaling cascade in stress responses, drug tolerance, and virulence in C MID1 HEL-S-84 RCN2 PMC10242157__F7 Versatile role of Serpina3c in physiological and pathological processes: a review of recent studies TLR4 ENO1 FOXO1 PMC7823885__F3 Pathways of lipid metabolism modulation in hepatic tissue by the Gl-2 extract of a Mexican strain of Ganoderma lucidum, under a high-cholesterol diet (HCD) given to C57BL/6 mice ME1 EGR1 FOS ACACA ATF3 DNAJB1 ACSS2 SIK1 EGR2 FDPS ELOVL5 FOXA3 MOXD1 HEL-S-70p BTG2 ACLY HSPA1A JUN FASN PMC6147049__F3 ER signaling pathway CCND1 IL6 HIF1A PMC6147049__F4 HER2 signaling pathway MDM2 GRB2 MTOR PMC6147049__F5 Canonical Wnt/Beta-catenin signaling pathway MMP7 APC GSK3B CD44 CCND1 PMC2933905__F2 Distinct functions for TPPII in the nucleus and cytosol ATM SSB BAX PMC11978336__F5 Interaction between lipid metabolism and macrophage polarization in atherosclerosis IL10 NLRP3 TLR4 ABCG1 ABCA1 PMC12170582__F5 This figure illustrates the diverse neuroprotective effects of Rut and its underlying molecular mechanisms BACE1 TLR4 NGF APP GDNF CA3 BDNF PMC9349561__F5 Exploration of molecular targets and mechanisms of Chinese medicinal formula Acacia Catechu ‐Scutellariae Radix in the treatment of COVID‐19 by a systems pharmacology strategy BAD AIP SORD BRCA1 NOD2 TSC2 MMP14 TRAF2 EMB SELE RBL2 STAR PAF1 ELL ITCH CD19 PMC12170582__F3 This figure reveals important factors in anti-inflammatory signaling pathway of Rut in the CNS microenvironment NLRP3 COX2 TLR4 ARG1 PMC1201250__F7 Mechanism of TgHSP70 tolerance in PMs from WT mice TLR4 IRAK1 TRAF6 IRF3 MYD88 TG PMC7847688__F3 Roles of Pin1 in virus infection PIN1 CCND1 STAT3 PMC6781638__F4 Pathway analysis shows the identified proteins and their respective interactions TMTC1 DAO FCGBP APOC3 DRD1 DRD2 UBB DRD4 MCAM APAF1 CASP9 SDHD SDHA APOE GIGYF2 SNCA SDHC NDUFB9 NDUFA6 APC FES TNF VDAC3 PRKACG HTRA2 PPIF RTN4R CACNA1I SLC18A2 GNAI3 ADCY5 COXFA4L2 UQCRB SLC1A1 OTUD7B SHANK3 GNAI1 ETF1 HEL-S-67p NDUFA13 APP ZDHHC8 COX7B NDUFB6 ADAMTSL3 NOTCH4 PTGIS NDUFS6 DPYD NDUFV2 LRRK2 RGS4 NDUFA7 NDUFAB1 NDUFS3 COXFA4 STAG1 SLC25A4 PRKD1 NFATC3 SLC25A6 NDUFA10 SRPK2 SMG6 DTNBP1 PPP3CC UQCRFS1 CFI NDUFV3 UBE2J2 ZNF183 UBE2J1 A2M NDUFS1 NDUFB8 NDUFA12 UQCRC1 NDUFA9 NDUFA11 COX6B1 UBA7 UQCR10 HEL-117 RGS6 COX7C NDUFS8 UQCRQ GPR37 NDUFS4 UBE2G2 NAB2 SYN2 EPC2 AMBRA1 COX6B2 ZNF536 NRGN SLC18A1 LAMA4 UQCRC2 COX8C TPSG1 NDUFC2 UQCR11 CLCN3 APOL4 UBQLN1 APOL2 ZNF804A GRM3 NDUFB7 NDUFB3 HTR2A BDNF UBE2L6 HEL-S-62p UBE2L3 PAK6 UBE2G1 MAD1L1 RERE NDUFB10 GNAL NDUFS5 NDUFB11 SNAP91 PRRG2 SLC25A5 DISC1 VIPR2 NDUFB2 NRG1 SNCAIP CASP3 ADORA2A PINK1 NDUFA2 NDUFB4 NDUFB1 UQCRH NDUFA3 CNTN4 CYC1 HCN1 NDUFC1 HEL-S-51e CYCS TCF4 PMC5974360__F10 Wnt/Beta-catenin and hedgehog signaling in myofibroblast differentiation WNT10A WNT7B FZD10 PMC2885761__F2 Schematical overview of the signaling pathway mediated by MC1R RAB27A MC1R PMC6678287__F6 Simplified pathways showing the effect of F-6 cell proliferation and death CASP3 CASP9 MTOR BAX PMC4699037__F1 Signaling affecting stem cells identity and their interplay with chromatin FGF4 SOX2 NODAL SMAD2 TES LIF FGF2 GSK3B KLF4 BMP4 STAT3 PMC11978336__F2 Interaction between lipid metabolism and macrophage polarization in atherosclerosis ABCG8 ABCG5 CRP CYP7A1 PMC11978336__F3 Interaction between lipid metabolism and macrophage polarization in atherosclerosis APOM VCAM1 SRA1 TNF PMC6121264__F5 Putative targets of up-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer, (B) PI3K-Akt pathway, and (C) protein processing in endoplasmic reticulum CHUK MAPK3 PPP2R1A SSR3 SSR2 AMFR FGFR1 CCND1 MAPK1 DKFZp434B2017 UBE4B SEC61A1 GANAB SKP1 HEL-S-107 ITGB1 DDIT4 GNG12 HEL-S-125m CANX UBQLN1 MBTPS1 DNAJB11 HEL-S-269 NPLOC4 RAF1 VCP TRAF4 PIK3R2 PMC11978336__F1 Interaction between lipid metabolism and macrophage polarization in atherosclerosis PC LPA BAX PMC3575576__F6 Proposed signaling pathway TWIST1 PMC4377308__F3 Genetic alterations of protein tyrosine phosphatases in human cancers PTPRT PTPN11 SRC CAD STAT3 PMC2908016__F2 Therapeutic HPV vaccines PMC6627937__F7 Graphical illustration of the proposed mode of FBXW5-induced regulation of intracellular signaling in gastric cancer FBXW5 ROCK1 SRC ARHA CDC42 PMC2708714__F2 Direct targets of WT1 identified in the Wnt signaling pathway NLK TBL1X APC DACT1 PMC6347501__F3 ‘Stemness’ maintenance pathways in CSCs APC PDK3 PDK2 GSK3B TEF LRP5 LRP6 SMO ABCG2 HIF1A HEL-S-133P PMC8394908__F3 Splicing factor mutations in hematologic malignancies MEPCE UPF2 ERF EIF4A3 UPF3B MAGOH CDK9 PMC8949786__F5 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning FOS SMAD2 SMAD6 TGFBR2 MAP3K7 RALA MAP2K2 RRAS2 MAPK12 HNF4A ZNF423 INHA BCL2 MAPK1 TMEPAI SMAD1 INHBB INHBA PMC8949786__F6 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning PIK3R1 MYH9 NCK2 ACTN1 HEL-S-15 MYC ITGB6 MYL6 FLNB MYH10 PARVA RHOU MAPK12 ATF4 CCND1 MAPK1 ACTN4 PPP2R2A CREB5 FOS MAPK10 ITGB1 KRT18 PS1TP5BP1 PIK3R4 RICTOR VEGFC LEF1 RAC3 ITGB8 NFKB2 TNFRSF1A FBLIM1 RHOT2 HEL113 PIK3R2 PMC3148591__F2 Major signaling pathways of IPC- and Ipost-mediated protection against cardiac cell death STAT3 PMC8204759__F1 Golgi-localised components that mediate mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) signalling RAB1A GOLPH3 ARF1 RHEB PMC3204848__F13 Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane COX1 PLCG2 PMC6470053__F8 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments H1-1 H1-3 H1-5 RC3H1 PMC3341711__F1 TGFB/Smad canonical signaling pathway SMAD2 TGFBR1 SMAD4 TF PMC6470053__F9 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments H1-1 H1-5 RC3H1 PMC9485288__F8 G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction ANKRD1 G3BP2 VCAM1 PMC8832959__F1 Cancer metabolism and dietary interventions ME1 BCAT2 ACSS2 CIT HEL-S-32 GOT2 ACAT1 BCAT1 KHK ACLY HEL-S-133P HK2 MAL PMC6001654__F1 Role of DKK4 in different signal pathway NR1i1 MAPK3 GSK3B CD44 CCND1 DKK4 PMC8096907__F2 miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases IL21R SOCS3 SNIP1 SMAD2 SMAD4 IL23R IRF4 SOCS1 STAT3 PMC7845572__F2 An overview of cellular metabolic pathways in MM cells PTEN HEL-S-133P HK2 PMC7879452__F6 In nucleus, Lnc-BTG3-7:1 co-regulates the transcription of C21ORF91 gene with nuclear synergistic transcription factor JUND GSK3B GRB2 JUND EURL PMC8002431__F4 Gene networks regulating flowering time showing differentially expressed genes in cid3cid4 PRR9 ELF3 PRR5 EFL1 ELF4 PRR7 PRR3 PMC8311559__F1 Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases APC MTOR IL1B STAT3 FOXP3 PMC6944118__F8 Working model of the role of HERC2 in p53‐MDM2 loop regulation NEURL4 HERC2 ATM MDM2 ATR PMC3742228__F2 Schematic overview of Hedgehog signaling and rationale for combination therapy with (chemo)radiotherapy PC ATM SUFU PTCH1 MMP9 GLI3 SHH SMO ABCG2 ABCB1 PMC7226770__F3 Blood–brain barrier, theoretically a motorway for a melting-pot of EXOs CD46 RAB27A RAB27B PMC2770887__F1 ER stress-induced signaling pathways that mediate autophagy ATG12 EIF2D MTOR DKFZp686F0183 PMC4110175__F5 LDN Inhibition in TGFB Signaling Pathway adapted from KEGG 04350 BAMBI TGFBR1 SKP1 RBX1 SMAD1 DKFZp781O1323 IFNG PMC5047918__F2 Simplified view of B PTS HEL-S-133P HEL-S-281 PMC4110175__F2 SP600125 and BCI Inhibition in MAPK Signaling Pathway adapted from KEGG 04010 NGF MAX EGFR INS GCK JUNB PMC8604912__F7 Molecular mechanism by which Lactobacillus spp. regulate the core fucosylation of epithelial cellsthrough the Wnt pathway WNT3 FUT8 PMC8353313__F6 Coeloglossum viride var. bracteatum extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3 CASP3 FGF2 DNMT3B CP PMC4444401__F6 Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent IL1R1 OSM IRS1 IL1B OSMR STAT3 PMC9117016__F9 Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-Gamma-Mediated Suppression of the NFKB and MAPK Pathways CTSK NFATC1 TRAF6 PMC9185832__F1 Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes IL18 MYD88 IFNG PMC7947359__F2 BPs in the macrophage polarization STAT1 NLRP3 PMC7195796__F6 Effect of P17 reovirus on cancerous signaling pathway CDK2 CCND1 TPR PTEN CDC2 CDK6 PMC4100983__F4 Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer IGF1R EGFR MTOR PMC4859317__F1 Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan GSK3B IL6 TNF MTOR HEL-S-162eP PMC4440397__F1 Calcium channels in T cells PLCG1 APC STIM1 PMC4678629__F2 Classical pathways of type I IFN induction and HCV mediating IFN resistance STAT1 STAT2 IRF3 TYK2 TLR3 MAVS PMC9496732__F3 Regulating the Expression of HIF-1A or lncRNA: Potential Directions for Cancer Therapy CDH2 PMC10990278__F1 The Wnt signaling pathway ZNRF3 RNF43 APC AXIN1 LRP5 LRP6 PORCN PMC8438241__F7 Sec62 Regulates Endoplasmic Reticulum Stress and Autophagy Balance to Affect Foot-and-Mouth Disease Virus Replication UVRAG XBP1 SEC62 PMC6708269__F1 Metabolism and Redox in Pulmonary Vascular Physiology and Pathophysiology PRX HEL-S-162eP PMC5745708__F9 PMSC differentiation into skeletal muscle using the insulin-like growth factor system SOX2 IGF1 IGF2 IGFBP6 MTOR IRS1 MYOG PMC7408912__F4 Scheme presenting the major proteins of the DNA damage response (DDR) signaling pathway and the miRNAs that interact with them ATM H2AX PMC7408912__F5 MiRNA regulation of homologous recombination (HR) repair factors after IR PALB2 ATM BRCA2 RAD52 RAD51 H2AX PMC3904625__F8 Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation FLI1 RUNX1 TPO ANKRD26 PMC8232085__F4 Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades C4B_2 CTSS HSP90AB1 ALB HEL-S-99n PDIA4 ALOX5 HSPD1 C4A COL1A1 FKBP1A IFNG STAT1 HEL-S-2a INPP5D MTDH HSD17B4 ABCB1 PRPF8 PGAM1 IL1B HSPA4 FASN HEL-S-89n HEXA FTH1 FGF2 PSMB2 PARP1 AKR1B1 DDB1 HEL-S-130P TCIRG1 CTSZ HMGA1 HEL-S-125m ITGAM C1QB HNRPA3 ERAP1 UBA2 ZYX YLPM1 S100A8 H2AC21 RAN THOP1 PSME2 PMC5823630__F6 Anti-estrogens mitigate mTORC1 inhibitor-induced activation of PI3K/AKT IGF1R IGF1 IRS1 INSR PMC4390903__F2 DNA damage pathways and how CHK1-, WEE1-, or CDK1 inhibitors can synergize with cytarabine to increase its DNA damaging efficacy in AML RAD1 SSB MRE11A WEE1 RAD17 ATM CDK2 HUS1 MDM2 RAD50 CDC2 ATR MYT1 PMC6245348__F6 Molecular network and proposed mechanism of activity.Notes: (A) The predicted mechanism for the reversal of cell survival, angiogenesis, and inhibition of apoptosis BAD EGFR VEGFA PTEN MTOR CASP8 BAX PMC4622404__F2 N-Glycan biosynthetic pathways in induced pluripotent stem cells (iPSCs), iPSC-derived cardiomyocytes, and human cardiomyocytes ST3GAL3 MGAT3 ST6GAL1 PMC10935410__F4 Protein-to-protein subnetworks involved in prolactin, leptin, BDNF, and neurotrophin signaling pathways in CD4+ lymphocytes PIK3R1 CHUK BAD HEL2 GSK3B MTOR STAT5B FYN PTPN1 PTPN11 SRC CCND1 SYN1 NCOA1 PTPN6 YWHAG NTRK2 BAX VAV1 HRAS IRS1 ERBB2 NFKB1 RELA GRB2 BCL2 RAF1 HEL-S-93 BDNF SHC1 STAT3 PMC8599049__F8 Interleukin 6 trans-signaling increases prostaglandin E2 production in human granulosa cells SOCS3 PTGS2 IL6 PMC312710__F8 RegA regulation by differential degradation UBC SKP1 PMC5961063__F1 Summary of ROS modulation during ECM detachment HEL-S-26 GCLM GCLC PRODH CD44 HEL-S-44 TXN PMC8639021__F3 Neurobiology of COVID-19: how can the virus affect the brain? TLR7 TLR4 IRF9 TRAF6 IRF3 IRAK4 MYD88 ACE2 TLR3 TMPRSS2 TIRAP PMC9323154__F1 Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential BAD FADD BAX PMC5584049__F6 AC6 and AC6-ΔN signaling CAV3 SRC STAT3 PMC5821947__F1 Regulation of expression and functional role of CD38 IL16 PMC4643957__F9 Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States LRP5 LRP6 BMP4 PMC11914587__F10 TGFB signaling SMAD2 TGFBR1 TGFBR2 PMC8763503__F8 STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway NR1i1 PMC5359955__F2 Title: In PI3K-Akt-mTOR signaling pathway, PI3K inhibits autophagy via activation of Akt TSC2 TSC1 MTOR RHEB PMC6094490__F1 Toll-like receptor (TLR) signaling pathways TBK1 CD14 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 PMC11914587__F14 Mitophagy in neurons ATG12 STAT3 SIRT3 PMC4127946__F9 Proposed model for the role of CD28, CTLA-4, CD80, and the PD-1/PD-L pathway in mice after ischemic stroke APC CD80 PMC7047153__F1 Innate immunity and antiretroviral activities IRF7 MYD88 PMC11914587__F11 Interactions between astrocytes, microglia and neurons leading to neuroinflammation NLRP3 CD14 HEL-S-44 IL1B PMC3785965__F4 p120catenin regulation of Rho-GTPase signalling ARHA CDC42 VAV2 PMC8970045__F3 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn TSC2 SEL1L CDC20 OS9 TSC1 SVIP SKP1 MTOR RBX1 UFD1L RHEB PMC8970045__F4 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn WNT4 CDK2 PCNA PMC7287096__F5 Schematics of trafficking deficits mediated by pathogenic LRRK2 or knockdown of Rab8a RAB8A LRRK2 EGFR PMC9070300__F2 Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade NLRP3 FYN TLR4 IL1B PMC7287096__F4 Schematics of EGFR degradation and recycling assays EGF RAB8A EGFR PMC7924360__F1 Modification of PtdIns Mediated by PI3K, PTEN, SHIP, INPP4 and the PI3K signaling pathway in cancer: The phosphorylated state of inositol lipids inserted in the cell membrane is controlled by inositol kinase and phosphatase enzymes PI3 PTEN PMC2975490__F1 Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis NLK APC LRP5 LRP6 ROR2 RHO PMC9284871__F7 Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4 MSC PTEN RPE NEDD4 PMC4349708__F3 Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms VASP BAD HEL-S-28 FLNA ARHA PTEN FLNB PARVA LAMA3 BIRC2 FYN CAV2 HEL114 ITGAV CDC42 PMC8039192__F2 Molecular mechanism of the Hippo signaling cascade LATS1 LATS2 PMC8039192__F3 Mechanism of the lncRNA-mediated regulation of Hippo pathway in cancer AMOT LATS1 EZH2 LATS2 FRMD6 PMC4083090__F7 A model of the role for ATRIP SUMOylation in the ATR pathway TOPBP1 ATRIP ATR PMC8912926__F7 Potential regulatory network of androgens and progestins regulating testis organization and spermatogenesis via Insl3 INSL3 CYP17A1 PMC7564391__F5 Major lncRNAs involved in taxane resistance SIK2 AAG1 BCL2 CDK4 PMC2929310__F3 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance TNFRSF9 CEBPE CYBA SCARB1 AMH AGER TNF ASB3 CEACAM1 PMC8310668__F9 Proposed schema of AZ, SFN, and AZ+SFN targeting the pro-survival pathways in BC PC KEAP1 SFN PMC8501670__F3 Caenorhabditis elegans as a model for obesity research FAT1 FAT3 FAT4 PMC4792095__F1 Inhibition of guanylate biosynthesis enzymes limits tumor invasion and growth GMPR IMPDH1 IMPDH2 PMC2929310__F6 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance MAX ATF2 TNF PMC11462682__F2 Hexosamine biosynthesis pathway and cardiac function OGA OGT OPA1 PMC8591138__F6 Identification of Cross-Pathway Connections via Protein-Protein Interactions Linked to Altered States of Metabolic Enzymes in Cervical Cancer TBK1 CCNA2 MPO RBBP4 DKFZp781B1423 FLNA CDKN2C GSK3B BUD31 BCL2L1 MTOR FZR1 FKBP1A HEL-S-67p CDK4 HSPA4 PER1 PLAUR NONO DNM3 PROX2 NASP TNF AURKA FUS TLR3 RFC3 RFC4 MCM3 RICTOR CDC20 CREBBP CDC6 VTN TYMS HEL-S-66 TRAF2 CROP ZRANB2 PMC6770969__F6 KEGG AMPK signaling TSC2 F2 INS MTOR ACD POC1A RHEB CFTR INSR PMC2994033__F1 Signaling complexes are induced by TNFA to mediate NFKB activation, apoptosis, and necroptosis TRADD CYLD TRAF2 FADD PMC9187215__F1 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? STAT1 STAT2 IRF7 IRF8 IRF9 SMAD2 TYK2 JAK1 PMC2775888__F2 Cellular mechanisms by which flavonoids and their metabolites protect against neuroinflammation and neuronal injury induced by 5-S-Cys-DA, DHBT-1 and related ROS STAT1 BAD IFNG PMC9187215__F2 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? STAT1 PDC STAT2 TYK2 IFNAR2 JAK1 PMC9099786__F2 Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis TRIM8 JAK1 IFNG STAT3 PMC6889432__F5 Notch, PI3K, TGFB, Wnt/B-catenin, and EGFR/Ras signaling pathways are interacting with each other SMAD2 APC EGFR GSK3B GRB2 SMAD4 PTEN MTOR PMC7147523__F4 CD11c+ microglia as a subset of microglia present through life and across conditions SIRPA CD47 ATM CSF1 PMC4592238__F10 Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro PTS TBP GIP PMC5980750__F1 Hippo-Yap signaling in ocular development and disease PATJ RUNX1 RUNX2 AMOT LATS1 PMC8386298__F2 Moving Towards Targeted Therapies for Triple-Negative Breast Cancer PTEN MTOR PMC6889432__F1 EGFR and PI3K signaling pathways in CRC TSC2 EGF TSC1 EGFR MYC GRB2 PTEN MTOR ELF4 RHEB PMC6889432__F2 Notch signaling pathways in CRC MIB1 VWF ADAM10 PMC10040549__F1 Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications FER LPCAT3 STEAP3 FACL4 TF PMC5241340__F8 Hypothesis of miR-567 modulation in healthy and BC cells SMAD2 SMAD4 PMC9576411__F2 Oxidative Stress and Intervertebral Disc Degeneration: Pathophysiology, Signaling Pathway, and Therapy NLRP3 COX2 KEAP1 PMC7226482__F2 Caspase-dependent and -independent apoptosis pathways utilized by cytotoxic T-cells (CTLs) and NK-cells and mechanisms of bone marrow microenvironment-mediated immune resistance SET HGF IGF1 MSC NDUFS3 TNF FADD STAT3 BAX PMC8007632__F7 Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGFB1/SMAD2/3 pathway and ABCC1 transactivation ATF4 TGFBR1 TGFB1 PMC3823134__F2 Schematic pathway of different steps of autophagy ULK1 ATG12 BCL2 MTOR PMC1410736__F1 Disposition of 17Beta-estradiol (E2) and metabolites SULT1A1 UGT1A1 PMC8641993__F1 Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation COX1 PMC8988245__F2 Endoplasmic Reticulum Stress of Gut Enterocyte and Intestinal Diseases MFN2 ATF4 XBP1 PMC3756827__F1 Sirt3 deacetylation targets, and regulation of Sirt3 expression and activity HEL-75 SIRT3 PMC9006951__F2 Alzheimer’s Disease: An Update and Insights Into Pathophysiology MMP3 GRID2IP COX17 PLG MMP9 GFAP PMC5509684__F7 Statistically differentially expressed genes GCNT3 MGAT4A OGT MGAT3 RELA GALNT3 REL GCNT1 FUCA1 IFNG PMC9006951__F1 Alzheimer’s Disease: An Update and Insights Into Pathophysiology GRB2 FGFR2 FGF7 PMC419935__F8 A working model for the CblSTR signal transduction pathway CBLC CP PMC9589357__F4 Transcriptome analysis of malate-induced Schizochytrium sp. FJU-512 reveals a novel pathway for biosynthesis of docosahexaenoic acid with enhanced expression of genes responsible for acetyl-CoA and NADPH accumulation ME1 CS PC SDHA HEL-S-162eP PMC11668798__F2 Sphingolipid rheostat targeting in adult-type diffuse gliomas PLPP2 PLPP1 SGPP1 PLPP3 SGMS1 CERS3 SGPL1 LASS1 SMPD1 CERS5 SGMS2 KDSR CERS2 SGPP2 PMC12027064__F2 The microbiota-induced expression of MMPs during OSCC PEAR1 IL8RB CXCL2 PMC12027064__F3 Microbiota-induced expression of MMPs in ECM remodeling during IBD and CRC IL10 TLR4 TNF PMC11720488__F1 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets TINAGL1 EGFR PTK7 HOXB5 PMC11720488__F2 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets RICTOR PRR5 PTEN MTOR DEPTOR PMC4428393__F2 Cytoplasmic folate-mediated one-carbon metabolism is required for de novo purine, thymidylate, and methionine synthesis MTHFD1 PMC1481516__F2 Metabolic pathway and bioenergetics of net citrate production in prostate cells CS CIT MAL PMC9278000__F2 Recent clinical findings on the role of kinase inhibitors in COVID-19 management NLRP3 BTK ACE2 IL1B PMC8946707__F1 Understanding the Notch Signaling Pathway in Acute Myeloid Leukemia Stem Cells: From Hematopoiesis to Neoplasia NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC6067656__F1 Schematic representation of human adrenal steroidogenesis PAPSS2 CYP11A1 HSD3B2 SRD5A2 POR HSD17B3 CYP17A1 CYP21A2 PMC11790428__F1 Signaling pathway of NOD1 ATG16L1 NOD1 IRF7 TRAF3 RHO IL1B PMC7439808__F6 Reductive Glutamine Metabolism and Serine-Driven Folate Metabolism Suppresses Mitochondrial ROS Accumulation to Support Anchorage-Independent Growth and/or Metastatic Disease HEL-S-26 MTHFD1 HEL-S-51e MTHFD2 MTHFD1L PMC8440421__F5 Chitosan-mediated cGAS-STING and inflammasome activation, and the promotion of Th1 responses TBK1 NLRP3 CGAS IRF3 IL1B IFNG PMC4891098__F6 WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells VEGFC HEL-S-28 PMC8909980__F6 Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3 TLR4 IRAK1 RELA TRAF6 IRAK4 IL6 MYD88 TNF IRAK3 PMC8992488__F2 Glioblastoma chemoresistance: roles of the mitochondrial melatonergic pathway PDC AHR CYP1B1 GSC AANAT PMC6512043__F8 T10 inhibited NFKB activity via miR155-5p/SHIP1 axis IL16 TLR4 TRAF6 CSA2 TLR1 PMC10572156__F7 Beta-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells SCD TNF MTOR FASN BAX PMC11015656__F1 Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review HEL-S-26 EGF HGF EGFR SRC RHO PTEN HIF1A DEPTOR PMC175791__F10 Differential regulation of NFAT and SRF by the B cell receptor via a PLCG–Ca2+-dependent pathway BTK BCR LYN SYK RHD CDC42 PMC3979452__F4 MiRNA regulation of skin fibrosis in epithelial and fibroblast cells SMAD2 ZEB2 SMAD4 PTEN PMC11015656__F2 20S proteasome inhibitors and their targets E2F4 CDK2 CCNB1 CDK4 TNF PMC8834318__F4 Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas ITGB1 PMC3298845__F1 Wnt/Beta-catenin signaling pathway in liver biology and disease APC LRP5 LRP6 PMC6599650__F1 Schematic illustration of the formation of pH- and redox-responsive, methotrexate-loaded, APP-derived micelles via self-assembly in aqueous solution MMP2 MMP9 APP PMC9626535__F10 MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome GPX4 BCL2 BAX PMC400410__F5 Functional associations of genes identified by discriminant function analysis (DFA) in patients with juvenile rheumatoid arthritis (JRA) who were undergoing treatment CD63 SLC2A3 IL1RN FTL INS NFIL3 TGFB1 CLU PMC400410__F3 Functional associations of genes selected as differentially expressed in patients with juvenile rheumatoid arthritis (JRA) and normal controls FPR1 INS TNF MX1 CBL IFNG NPAT PLN CASP3 APP SRC B2M PRR3 PMC400410__F4 Functional associations of hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA) HLA-A ZNF263 DAP TNF RANBP2 TGFB1 HEL-S-130P hCG_1998026 MYOD1 IFNG HLA-C PMC5932495__F2 The role of inflammasomes in Parkinson's disease and Alzheimer's disease NLRP3 IL16 CDK5 MYD88 NLRP10 PMC5463201__F2 Endogenous sources and consequences of ROS overproduction NOX3 DUOX1 DUOX2 NOX4 NOX5 PMC5463201__F3 Examples of NOX signal transduction MMP2 NOX4 EIF4E NOX5 STAT3 PMC1804347__F4 Systemic sclerosis: a prototypic multisystem fibrotic disorder EGR1 TGFBR1 RHO RAC1 SP1 MAP3K7IP1 CDC42 PMC10987301__F3 visually outlines the RAS/microRNAs (miRNAs) pathway in cancer metastasis, emphasizing the pivotal role of the Ras signaling pathway, particularly in tumor initiation and metastasis RASSF1 GRB2 PMC8166856__F7 STAT3 in gefitinib resistance EGFR SRC STAT3 PMC7490765__F5 Molecular basis of drug resistance in cancer IGF1 ATM EGFR SRC MTOR ATR PMC3438084__F6 A subset of the up-regulated genes with known function in response to maize root exudates PTS HEL60 PMC4193161__F8 A simple model was constructed on the basis of transcriptome data PC BAK1 RGR ERF PMC6695670__F2 Toll-like receptor (TLR) signaling TBK1 TLR5 TLR9 IRAK2 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 TIRAP MAL PMC5983921__F3 Wnt/Beta-catenin signaling pathway ZNRF3 EP300 APC TEF LRP5 PMC8585982__F1 CAR-T: a potential gene carrier targeting solid tumor immune microenvironment CD80 PMC5412337__F1 Current strategies for targeting the epidermal growth factor receptor (EGFR) pathway EGF HGF MTOR STAT3 PMC8748960__F4 Training associated alterations in equine respiratory immunity using a multiomics comparative approach IRF9 PIAS1 TYK2 IRF-1 IFNG BAX PMC8497895__F2 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer CGAS ATM APC CD80 CTLA4 ATR PMC11794105__F1 Signaling pathway regulating EMT in epithelial cells SMAD2 APC JUN PMC8497895__F1 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer WEE1 ATM ATRIP SSB RAD51 CDC2 ATR BRCA1 PMC4158168__F6 Signaling pathway that metformin uses to regulate T cell and osteoclasts in autoimmune arthritis TRAF6 MTOR STAT3 PMC7483800__F3 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease NAPRT NAMPT SARM1 NRK PMC7831909__F2 Sulforaphane targets Nrf2 pathway to prevent kidney disease progression KEAP1 VCAM1 AKR1C1 NQO1 PMC7483800__F1 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease NMNAT2 STMN2 SKP1 SARM1 PMC6492912__F1 The nicotinamide adenine dinucleotide (NAD) biosynthetic pathways in mammals NAPRT NAMPT NRK PMC3721034__F2 MDM2-p53 pathway revisited TIGAR HIPK2 SCO2 ATM E4F1 BAX PMC10991944__F1 Metabolic engineering of methylotrophic Pichia pastoris for the production of Beta-alanine ASPDH ASPA CIT MAL PMC11670207__F6 Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis PIK3R1 MAPK3 ASPA FOXO1 HEL-S-162eP CDKN1A RELA LEPR MAPK1 JAK1 PPARG JUN SIRT1 PER2 STAT3 BOK PMC3721034__F5 MDM2-p53 pathway revisited PML HIPK2 RYBP JMY MDM2 RPL26 RNF2 PMC11670207__F7 DEGs in growth-related pathways IKBKB PIK3CD PIK3R1 FOXO3B PCK1 SOS2 GRB2 JAK1 RRAS2 MTOR PCK2 STAT3 PMC11659141__F4 Complement and coagulation genes are differentially expressed in head kidney samples between A HEL-S-62p CD59 CS C7 PMC3066048__F1 Complementation of Saccharomyces cerevisiae coq7 Mutants by Mitochondrial Targeting of the Escherichia coli UbiF Polypeptide COQ3 COQ2 COQ6 COQ5 PMC5165248__F1 Simplified schematic depiction of a hypothetic PrPc-induced signaling cross-talk between PI3K/Akt and Wnt/Beta-catenin pathway under hypoxic conditions EGR1 GSK3B HEL-S-133P PRNP PMC7603558__F6 Signaling pathways involved in the actions of the 12 herbs against OvCa TLR4 CD40 PMC2687355__F7 The signaling pathway MyD88 ⇒ p38 ⇒ EGR-1/AP-1 is essential for GBS-induced transcriptional activation of TNF EGR1 MAL PMC8110832__F3 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer NAMPT SLC5A8 MEF2C SIRT1 PMC8110832__F1 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer PCK1 EGFR HK2 HEL-S-162eP PMC2637482__F2 Crosstalk between Robo4/Slit2 and VEGF signaling pathways ROBO4 RAC1 SLIT2 PMC6485244__F2 NFKB-BRD4 signaling in innate inflammation and remodeling SNAI1 IRF7 RELA IL6 BRD4 PMC7503576__F1 Bile acid synthesis pathways CYP27A1 GCA CYP8B1 CYP7B1 CYP7A1 PMC8045781__F2 Oncogenic RAS-dependent control of cellular metabolism ME1 COX2 GPX4 GOT2 ENO1 RPIA RPE GFPT1 HK2 FASN GLS PMC5406893__F7 Summary of the survival and growth phenotypes in breast cancer BAD IGF1R EGFR RAF1 MCL1 MTOR PMC5790481__F13 Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling ME1 CD14 HMGB1 IL18 TLR4 MYD88 IL1B MAL PMC11682973__F1 The PI3K/AKT/mTOR signaling pathway TSC2 ULK1 TSC1 ELF3 FOXO3A F3 ATG101 PTEN IRS1 FOXO1 RHEB PMC7692672__F1 Synthesis and metabolism of sphingolipids (SLs) PC DES GLS PMC9465647__F1 Resveratrol on rheumatoid arthritis: From bench to bedside KEAP1 FOS RELA SIRT1 PMC7736467__F6 Cannabinoid signaling pathways affecting neuronal extension length SRC ARHA BRCA1 STAT3 PMC9125579__F10 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues TRPM5 SNAP25 TG GPR119 HMFN0839 TRPC1 GPAT4 GPAT2 TRPC3 TRPM2 ORAI1 STIM1 CD36 PMC5078498__F1 Dopaminergic miRNA nodes in a rich network of connections in synaptic plasticity pathways CHP1 PRKAG2 PMC7082880__F5 Drugs targeting Wnt pathways in cancer treatments ZNRF3 RNF43 LRP5 PTK7 LRP6 GPR49 PMC11576406__F4 Pathways significantly affected by shear stress in HBMECs(A) Effects of physiological shear stress (1 CD58 CXCL1 CD99 CXCL5 ICAM2 ESAM CXCL8 CXCL3 ITGA4 CXCR6 SELL CXCL13 CXCL16 PI3 CAV3 BCR CD2 CXCL6 CAV2 PECAM1 SELE CXCL11 CXCR1 CD34 CXCL10 CXCR5 IL8RB CXCL2 MCU TRDN ITGB1 PLN CXCR3 ITGAM TNC TFEB ICAM3 ITGB7 CXCR4 CXCL9 GLG1 CD40 HRC SELP CXCL12 CD226 JAM2 PMC7082880__F2 Wnt signaling pathways RNF43 ATF2 APC GSK3B PTK7 RYK LATS1 RHO LATS2 FYN MUSK TEF JUN STAT3 CDC42 PMC11576406__F6 Pathways significantly affected by iRBC exposure in HMBECs(A) The endosomal signaling pathway was affected by co-incubation with ring stage iRBCs and shear stress (1 CXCL1 CD99 SMAD2 ESAM CXCL8 CXCL3 SNX12 VTA1 CXCR6 TSG101 CXCL13 CXCL16 LDLR SRC CXCL6 AMPH SNX3 PECAM1 CAPZB CXCL11 SNX1 VPS35 RAB35 CXCR1 EEA1 CXCL10 EHD2 SNX5 EHD3 CXCR5 IL8RB CXCL2 ARHA CHMP3 VPS28 RAB10 CXCR3 CHMP6 VPS25 CXCR4 CXCL9 SNX4 CXCL12 ARF6 JAM2 CDC42 PMC6305747__F2 Pentraxins-expanded network of complement activation and regulation HEL-S-62p FH CRP PTX3 CP PMC7078296__F7 Helicobacter pylori-induced adrenomedullin modulates IFN-Gamma-producing T-cell responses and contributes to gastritis AGA ADM RAMP2 STAT3 PMC4369672__F1 Intracellular signaling proposed to be involved in the inflammatory response during immune-mediated joint diseases such as aseptic loosening HMGB1 TBK1 TLR5 TLR9 IRF7 IRAK1 DDX41 TRAF6 IRAK4 IRF3 IFNB1 S100A9 MYD88 TLR1 NOD2 NOD1 S100A8 IL33 IL1B TIRAP IFI16 PMC4369672__F2 Simplified overview of the RA-associated inflammation-promoting factors SFRP4 WNT3A DKK3 ROR2 IL1B PMC7163451__F8 Schematic diagram about the central role of co-treatment with Beta-elemene and cetuximab in ferroptosis induction and migration inhibition GPX4 STEAP3 SLC7A11 SLC3A2 SLC40A1 TF PMC8706759__F1 Targeting DNA repair pathway in cancer: Mechanisms and clinical application ATM BRCA2 SSB XPC PARG ATR PNKP PCNA PMC8706759__F3 Targeting DNA repair pathway in cancer: Mechanisms and clinical application CGAS ATM IRF3 ATR PMC11455816__F8 Schematic of MAGL blockade-mediated protection from GC-induced bone homeostasis imbalance RUNX2 LPL PMC8618597__F5 Leucosceptoside A from Devil’s Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes STAT1 DEFB4B HP PTGS2 CCL20 IL17A IL22 DEFB1 IL6 CCL2 MKI67 S100A7 PMC8485741__F1 Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection STAT2 IRF7 IRF9 IRF3 MYD88 TRIM25 TLR3 MX1 STAT1 ISG15 TLR8 TLR7 TYK2 MAVS PMC4172968__F11 Schematic representation of the signaling pathway proposed for the AhR-dependent control of cell migration AHR CSK SRC PMC10459054__F1 Typical pathway of miRNA formation DGCR8 DROSHA RAN PMC10459054__F4 Natural Products Treat Colorectal Cancer by Regulating miRNA MMP3 PTBP1 PMC10459054__F2 Anti-cancer mechanisms of five agents (1) resveratrol induces growth inhibition and apoptosis in colon cancer DLD-1 cells by reducing miRNA-96 expression through MAPK/ERK1/2 signaling pathway activation GCNT3 ERBB3 EGFR EVI1 MTOR STAT3 BAX PMC9254480__F1 VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment MAPKAPK2 VEGFC BAD FYN NRP1 VEGFD VEGFA RAF1 MTOR VEGFB NRP2 CDC42 PMC9546106__F2 Neutrophil granule proteins in orchestrating inflammation and immunity c-fgr TLR9 SYK DOCK2 PMC4378458__F4 NAD+biosynthetic pathways NAPRT NAMPT HEL-S-90n PMC9666786__F1 Crosstalk between enteric serotonergic neurons and colorectal cancer stem cells to initiate colorectal tumorigenesis HTR1B AXIN1 TPH2 CCND1 HTR1F HTR1D PMC11287639__F1 SMAD4 in the transforming growth factor-beta (TGFB) signalling pathway BMPR2 ACVR2B BMP10 ACVR2A BMPR1A BMP2 TGFBR1 TGFBR2 SMAD1 DKFZp781O1323 BMP4 SMAD9 PMC2778287__F6 Schematic representation of a dualistic model depicting the development of ovarian cancer BRAF BRCA2 EGFR PTEN BRCA1 PMC2678157__F9 The steroid synthesis pathway showing genes regulated in this study HSD11B2 HSD17B3 STAR HSD3B7 PMC6317954__F4 Metformin combined with Abs or small molecular inhibitors in cancer treatment IGF1 EGFR MTOR PMC3146784__F2 TLR ligands and signalling TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR3 TIRAP PMC9437261__F7 Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice MMP9 FXR1 JAK1 STAT3 PMC6317954__F1 General molecular mechanisms of metformin on inhibiting cancer cell growth IGF1R IGF1 MTOR PMC4691138__F1 Schematic presentation of proposed molecular epigenetic mechanism of sulforaphane’s action including interdependence between histone modification and DNA methylation SFN PTEN PCNA CCND2 PMC9299441__F8 Neutrophil Survival Signaling During Francisella tularensis Infection BAD GSK3B BAX PMC5382021__F6 Group B Streptococcus degrades cyclic-di-AMP to modulate STING-dependent type I interferon production TBK1 CGAS IRF3 PMC7565808__F1 Micropeptides encoded by lncRNAs regulate tumor malignant behaviorsa Linc00998 encodes micropeptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation SQLE SP4 IGF2 RPS6 BPI SMIM22 STAT3 PMC8041881__F4 IL-17 signaling pathway TRADD TRAF3 LCN2 IL4 USP25 REL FADD ELL PMC11978694__F5 MiRNA in treatment of gout arthritis NLRP3 EREG TLR4 NFAT5 ZEB2 VEGFA KLF2 MYD88 SOCS1 PMC4306190__F4 Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview HMGB1 VCAM1 S100B PMC7139574__F1 Biological pathways involved in chronic lymphocytic leukemia (CLL) pathogenesis and harboring therapeutic implications BTK BCR ATM BIRC3 TRAF3 RELB CD40 PLCG2 TRAF2 FBXW7 LTBR PMC6549020__F1 cTAZ: a safeguard factor of antiviral response TBK1 STAT1 STAT2 IRF9 ACVR1C IRF3 FOXP3 PMC11978694__F2 Molecular pathways involved in gouty arthritis and potential miRNA regulators NLRP3 TLR4 ARHA PTEN MYD88 MTOR SIRT1 GSDMD PMC9663420__F6 P2RX receptors and inflammatory markers in SCZ NLRP3 P2RX7 SERPINA3 P2RX4 PMC3185489__F1 Diagram connecting the insulin pathway and fatty acid (FA) biosynthesis SCD LPA MTOR IRS1 PMC7240781__F8 Crosstalk between the adrenal steroidogenic regulatory network and the immune pathway PGR GRN IL1B PMC5483452__F8 Schematic illustrating the role of Nupr1 in METH-induced apoptosis and autophagy in neuronal cells NUPR1 TRIB3 MTOR PMC8320172__F3 Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? EGFR MTOR ACE2 PMC7730574__F5 Anti-inflammatory activity of Ep-ME when targeting TAK1 in the AP-1 signaling pathway TLR4 IRAK1 IRAK4 MYD88 JUN TLR3 PMC6497798__F3 Targeting of host gene expression by Toxoplasma gondii STAT1 SOCS2 EGR1 CD40 IRF4 SOCS1 STAT3 PMC9589293__F2 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses MAP2 EGFR RAG1 ALB GSK3B SMAD4 ALKBH5 HMOX1 IPO11 ITIH6 ARFRP1 UBC MAF ANKS1A HTATSF1 BCAS3 PNLIPRP2 ARD1A AGTPBP1 MAP4 RSAD1 SCD TMUB1 TBC1D8 ZNF12 ZNF135 BST1 hEMMPRIN CASP8AP2 ARHGAP29 COX7C NLRP1 DKK3 CGA PNLIP HMGCR MAP2K1 UBA2 MIB2 PMC9589293__F3 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses KIF23 CD33 CTCF DPF3 MYC CCR8 IFT22 DGKG CYB5B TMEM41A LARP1B FHAD1 TCEAL7 TIGD4 ADGRV1 CHURC1 RNF24 PCDHA11 DEF6 bK150C2.9 TCF3 RBMXL1 POLR3B SRSF8 HMGCS1 JARID2 SPEG AARS1 WWTR1 IL10RB ABCD4 CREBBP CRB1 PMC9589293__F4 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses ChAT FOSL1 SMAD2 DYRK3 ADFP TMEM119 GSTM2 HBA2 CD59 HEL-S-277 PLAT FADS2 CYGB MOK ACLY MSMO1 PMC5040224__F2 Major regulatory pathways involved in the regulation of Runx2, a chief transcriptional regulator of osteogenesis LEF1 RUNX2 BMP2 GSK3B DKK1 DKK2 SMAD1 DKFZp781O1323 BMP4 PMC6497798__F1 Autophagy initiates host immunity and Toxoplasma immune evasion EIF2A SRC CD40 STAT3 PMC7504854__F3 Mechanism by which A20 regulates arthritis TRADD RIPK3 TRAF6 MYD88 TNF GSDMD NLRP3 RIPK1 TRAF5 TRAF2 IL1B FADD MLKL TAB3 PMC3185489__F4 The effects of HCV on steatosis development APOB SCD NR1C1 PMC11755957__F8 Cellular response in bovine sperm after frozen-thawed NGF HEL-S-67p HEL-S-128m CLU PMC7640369__F6 Pathways in which radiosensitizing effects of c-myc gene knockdown induced G2/M phase arrest by intrinsic stimuli through the mitochondrial signaling pathway CCNB1 CCND1 PMC3185489__F2 Some of the effects brought about by HCV on insulin signaling in hepatocytes PKD1 MTOR IRS1 PMC8436723__F4 Screening a Prognosis-Related Target Gene in Patients with HER-2-Positive Breast Cancer by Bioinformatics Analysis MCM2 CDC6 CDK2 SMC3 CYC1 DBF4 PCNA ORC2 SKP2 PMC3605881__F6 Scheme of mechanisms underlying attenuation of cardiac dysfunction induced by endotoxin, after NG-R1 treatment TLR4 TRAF6 MYD88 PMC8012432__F1 Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells STS CYP11A1 CYP17A1 PMC10487928__F4 Gamma interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins DOK4 CCNA2 H2BC9 H2BC3 CCL2 MX1 ISG15 OAS3 JUP LGALS3BP CDC2 hEMMPRIN CALD1 SNCA PTK6 RIN1 MARCHF8 ID1 HIST1H1E H1-1 MCM2 ERBB2 SIGLEC10 EPHA2 TGFA EPHB2 H4C9 PMC6640647__F2 Simplified TGFB signaling pathways NODAL CDK2 MYC ARHA MTOR PMC8819604__F3 Pathophysiological Pathway Leading to the Development of Valve Calcification in Chronic Kidney Disease PCSK9 FGF23 PTH LPA PMC3830198__F4 Model showing the proposed mechanisms of lncRNA-mediated regulation of the RB pathway CDK4 CDK6 PMC3830198__F5 Model showing the proposed mechanisms of lncRNA-mediated regulation of the p53 pathway ATM MDM2 ATR PMC8132131__F4 Interplay between hydrogen sulfide and other signaling molecules in the regulation of guard cell signaling and abiotic/biotic stress response KIN PMC4369647__F2 Signaling pathway associated with CD37 ligation by SMIP-016 CD37 LYN GSK3B SYK PMC11754069__F1 Intrahepatic network and metabolic signaling in NAFLD ERN1 ACSS2 KHK ACLY XBP1 MTTP PMC11754069__F2 Extrahepatic organ-specific networks associated with NAFLD SPARC FGF21 POMC NPY AgRP FGF19 CYP7B1 GIP PMC6460526__F2 CYLD-associated signaling pathways TRADD CYLD SUFU RELA RELB SMO CDH2 MAP3K7IP1 TRAF2 JUN LTBR PMC10003241__F3 Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease RUNX2 ASNS LRP5 SLC7A7 LRP6 COL1A1 SLC1A3 GLS PMC4906788__F2 TGFB signaling pathway BAMBI FST E2F4 NODAL SMAD4 SKP1 ARHA THBS1 TNF LTBP1 IFNG PMC4755536__F7 De Novo Transcriptome Assembly and Characterization for the Widespread and Stress-Tolerant Conifer Platycladus orientalis PRR9 ELF3 PRR3 PMC7400738__F2 Biogenesis, secretion, composition, and application of exosomes as liquid biopsy TSG101 CD9 CD63 CD81 PMC7001864__F1 Molecular Control of Canonical WNT Signaling ZNRF3 RNF43 KREMEN1 APC NOTUM AXIN1 LRP5 PORCN DKK1 GPR49 DVL1 PMC7001864__F3 Impact of WNT Signaling on Cancer Immunosurveillance BATF3 IDO1 CXCL10 DKK1 FOXP3 PMC10041388__F1 Metabolic reprogramming in cancer: Mechanisms and therapeutics OGT ENO1 PCK2 HEL-S-133P HK2 PMC6928102__F8 Proposed model of the EPHB2 signaling cascade that regulates the synaptic plasticity through the phosphorylation of AKT under neuroinflammation-associated perturbation of glutamatergic transmission BDNF GAD1 GLS PMC6905197__F1 Hippo signaling pathway LATS1 MOB1A PMC6928102__F5 Correlation network between the significantly changed metabolites and proteins of the hypothalamus in the LPS group compared with that in the CON group ChAT HSBP1 PRKX JPT1 BORCS6 NECTIN2 EDC3 PPIP5K1 CDC42EP4 CRH PTPRO LAMTOR2 PTPN4 ROBO1 SH2B1 ARHGEF17 GRB10 PGAM5 PMC9653955__F13 Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1 Inhibitor against Ovarian Cancer Cells In Vitro and Affect the Wnt Signaling Pathway TRPV2 F7 DVL2 RAD51 DKK1 PMC3820524__F1 Overview of hemostasis TFPI APC PMC7072767__F4 PINK1-Parkin pathway regulates IPAS expression and inhibits neuronal death PINK1 RING1 PMC7356809__F3 FAT10 is expressed in response to RNA virus infection and acts as a negative feedback regulator of RIG-I activation IRF7 TRAF3 TRAF6 IRF3 TRAF2 MAVS PMC6237963__F6 Cell cycle regulation pathway and the genes whose expressions were altered by 11-KT E2F4 PLK1 SMAD2 SMAD4 DBF4 ORC3 CDK7 CDK6 CCND2 UBC CCNB1 MDM2 CDK4 CDC2 RAD21 RBL2 CCNE2 APC CDC25B STAG1 CDC45 STAG2 CCNB3 CDC20 CDC6 SMC3 CCNB2 PCNA SKP2 MYT1 PMC6022559__F6 Subnetworks of breast cancer subtypes INPPL1 EGFR MYC TLN1 PLCB1 CARD11 ACVR1B MSH6 IBSP PIK3CA SPOP PTPRM PER1 PMC5061729__F1 EGFR signaling pathway modified from MetaCore® PLCG1 IGF1R EGFR GRB2 SRC SHC1 CBL NCK1 PMC9009225__F5 Qinggan Huoxue Recipe Alleviates Alcoholic Liver Injury by Suppressing Endoplasmic Reticulum Stress Through LXR-LPCAT3 LPCAT3 EIF2A ATF1 XBP1 PMC8847441__F5 Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development HES5 RBPJ NOTCH1 HES1 PMC11050203__F1 Activated signaling pathways: (a) the Wnt signaling pathway is activated in the presence of Wnt APC LRP5 MDM2 MTOR PMC8365519__F5 Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells POLE FLNA MYC NACA RHOB SNRNP200 PMC10974426__F1 Virus-activated intracellular signaling pathways STAT1 CGAS IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 IRF-1 PMC3962044__F1 NFKB signaling pathways in osteoclast lineage cells TRAF3 RELB TRAF6 TRAF2 TAB3 PMC3962044__F3 IAP antagonists and NFKB signaling in osteoclast lineage cells RIPK1 TRADD TRAF3 RELB TRAF2 PMC6260925__F6 Senescence prevention by HO‐1 activation PINK1 PMC7120155__F11 Antifibrosis therapy FRK LPA MTOR PMC5904200__F2 Simplified scheme of established complement activation pathways HEL-S-62p C5AR1 CD59 FH CRP C5AR2 CD55 C3AR1 CR1 PMC7762936__F2 Post-translational regulation of the long and winding cholesterol synthesis pathway LBR IDI2 EBP SC5D DHCR24 MVK IDI1 HSD17B7 MARCHF6 HMGCR ACAT2 PMVK MVD DHCR7 FDPS PMC3171365__F2 Bayesian network fits for mutation data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1); (b) Bayesian Information Criterion (maximum indegree of 2) RB1 ATR CDC34 CDKN2A CCNG2 RBBP8 FANCG CCNE2 PMC3171365__F3 Bayesian network fits for wildtype data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1) RB1 ATR CDC34 CDKN2A CCNG2 RBBP8 FANCG CCNE2 PMC5807685__F1 Canonical hippo signaling pathway PATJ AMOT LATS1 MOB1A MOBKL1A LATS2 PMC9099564__F2 Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives SPARC SOX2 PTN CD44 BMI1 RHO SPARCL1 MTOR OLIG2 PMC6802183__F7 Model structure consists of HIF-1A signaling, tumor signaling, and ATP depletion modules NF1 EGF EGFR GRB2 HEL164 PTEN AMN PMC8352569__F3 DNA Methylation of PGC-1A Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder MFN2 NRF1 GABPA FIS1 STOML2 OPA1 PMC8010885__F6 Cholesterol associated changes in cancer cells and available therapeutic targets ABCG1 LDLR NPC1L1 ABCA1 PMC10758146__F1 Lithium exerts neuroprotective effects in ischemic stroke through multiple mechanisms NLRP3 MTOR BDNF PMC7597592__F9 Proposed model of how TNFA and RIPK3 induce KC death following PH RIPK1 RIPK3 IL6 CCL2 FADD PMC2918404__F8 Osteogenic Transcription Factor Runx2 Regulates Components of the Fibroblast Growth Factor/Proteoglycan Signaling Axis in Osteoblasts FGFR1 RUNX2 FGF2 PMC3555197__F1 LXRs and prostate physiology: potential beneficial actions of LXRs over prostate cancer BAD ABCG8 ABCG5 ABCG1 LDLR ABCA1 PMC11899595__F1 Key molecular mechanisms/rationales for targeted agents in mantle cell lymphoma (MCL) BTK IKZF1 CXCR4 LYN BCL2 SYK CXCL12 MTOR IKZF3 CD79A CRBN BAX PMC3567093__F6 Somatostatin Derivative (smsDX) Targets Cellular Metabolism in Prostate Cancer Cells after Androgen Deprivation Therapy HEL-S-26 ENO1 GLUD1 ACAT2 PMC6695833__F1 YAP1/Hippo and wild-type p53 pathways coordinately maintain genomic stability in response to stress YAP1 MDM2 LATS1 LATS2 TF PMC6695833__F2 Transcriptional co-ordination between YAP1/Hippo and p53 family proteins in tumorigenesis or apoptosis PML ACTL6A WWC1 YAP1 CCNB1 MDM2 TP53AIP1 CDC2 BAX PMC7582405__F5 Most significant IPA networks involving the proteins that were differentially regulated between the CF and control states SERPINC1 APOA4 CFI PMC5486846__F1 The extrinsic and intrinsic apoptotic pathways, as well as the inhibitory effect of various IAPs on pro-apoptotic molecules NAIP TRADD TNF FADD PMC8318865__F7 Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses PLSCR1 STAT2 IRF7 IRF9 IRF3 IFNAR2 MYD88 TLR1 IFNAR1 IFITM1 STAT1 TLR4 IFIH1 PMC8576660__F2 Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy GSK3B MYC GRB2 SRC GRB10 STAT3 PMC12197781__F6 Effect of Ad14 miRNAs on the NFKB signaling pathway TBK1 EGF CHUK BTRC NGF TRAF3 TRAF6 PLCG2 MYD88 UBE2V1 HDAC2 CASP8 BMP2 HEL-S-71 TNLG2B TNF MAP3K7IP1 HDAC1 TNLG7A CARD11 LTA TNFSF11 TRAF5 RELA LCK ZAP70 CD40 MAP3K8 GH1 TNFAIP3 TNFRSF17 TRAF2 FADD TIRAP TAB3 PMC9180607__F5 Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration YAP1 RFX1 CCN3 SP1 SP3 HK2 CTGF PMC8624704__F5 Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response ADORA2A CXCL1 EP300 PTN PAFAH1B1 ALK PTCH1 FGF2 SHH NRG1 PMC4412127__F1 Signaling pathway regulation of ΔNp63 IRF7 SUFU GLI3 EGFR GSK3B IRF3 FGFR2 STAT3 PMC4551923__F8 Rad4–Rad23 and GG-NER E3 ligase function in DDR signalling and dNTP synthesis PMC7291293__F3 Summary of caveolae/CAV-1 in signal transduction during virus infection SRC ARHA RAC1 PMC8507004__F7 Promotion of chemerin in rat diabetic kidney disease through enhancement of TGFB1/Smads/CTGF pathway SMAD2 SMAD4 CCRL2 PMC4112878__F1 Endoplasmatic reticulum stress caused by saturated free fatty acids BAD BIK BAX PMC4506078__F4 Adaptation of a Bioinformatics Microarray Analysis Workflow for a Toxicogenomic Study in Rainbow Trout BAD PGR INS SMAD4 DBF4 ORC3 CDK7 CDK6 CDC20 IGF1 MDM2 CDK4 STAG3 LAT PCNA MYT1 REC8 PMC5077201__F6 Possible model of TIPE2 inhibition of activation of TAK1 signaling TRAF6 MAP3K7IP1 TRAF2 PMC7650600__F8 KIR2DL2/L3/S2+ CD8+ T cell cluster analysis of the protein-protein interaction (PPI) network with STRING database IFIT3 CD58 CCR3 UBE2D3 EGFR TGFBR1 SMAD4 CD244 WAS DNMT3B RDX FBXO6 RPS24 CCR1 IFNG EIF3J RPL36A TAF15 FBXW4 ZBTB16 PRF1 RPS27 RUNX3 ACVR1 FOXO3A IRF7 RPL36 RPL35 NUP214 CD44 RPL37 KCNC3 KIR2DL2 RPS3A GTF2H5 HLA-F NME7 RPL17 HLA-A FCGR3A HLA-DPB1 TNFRSF1B MAP2K1 RPL29 CDKN1A ADCY6 RPL7 CCL3 PMC9271773__F2 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy ATM EBP CAST VAV2 PMC9002106__F3 Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials NLRP3 COIL TNF PMC5154531__F6 Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway NPR2 NPR3 CNP PMC7697003__F4 FAK involvement in rhabdomyosarcoma TSC2 HGF IGF1 SRC MTOR PMC9271773__F5 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy SIRT6 EGFR MYC PMC4943290__F1 Agents acting on the renin–angiotensin system pathway ©PharmGKB REN AGTR1 BDKRB1 NR3C2 ATP6AP2 AGTR2 CTSG MAS1 MAPK1 CMA1 BDKRB2 ACE2 TGFB1 MME PMC4877005__F3 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure PCLO ANK2 SYNJ1 ATP2B4 GRIN1 BSN ATP2A2 SPTAN1 ATP2B3 ATP2B1 SYP PMC9096244__F2 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma ERBB2 EGFR CCND1 AJUBA MTOR CDKN2A FBXW7 PMC9096244__F3 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma TSC2 RICTOR BAD PTEN RPS6 MTOR IRS1 PMC4951461__F2 Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls IDO1 TPH1 CRAT PMC2668232__F5 Principles in TLR signaling TBK1 TANK TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 MAL PMC1963413__F1 Oval of iNOS-inducing signaling pathways ATF2 NAPA TLR3 PMC3572009__F5 Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients CXCL1 HSD11B1 NTS RGS2 TNFRSF11B ITGA2 TNC F13B CCL15 CCL20 MASP2 SPHK1 THBS1 KNG1 HEL-S-43 PMC9263829__F1 Can the cGAS-STING Pathway Play a Role in the Dry Eye? VCAM1 IL1B PMC3694976__F10 Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia PIM1 EPO IL6 CBL PMC4877005__F2 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure ANK2 AP2A2 PLEC ACTN1 ACTN2 CNP NEFH NCAM1 SPTBN2 SPTBN1 SPTAN1 VCP ACTN4 PMC4593313__F1 Cellular interactions in normal and diseased vasculature FGF4 FGF23 FGFR1 RUNX2 VCAM1 FGF2 FGF8 FGFR2 PMC204456__F5 Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans CIRSR EGFR GRB2 HEG1 PMC6887797__F1 TSC2 mediated crosstalk between the Akt/mTOR pathway and the cyclin D1-CDK4/6 axis.The cyclinD1/CDK4/6 axis is responsible for increased phosphorylation TSC2 and TSC1, and promotes the phosphorylation of the mTOR substrates, 4E-BP1 and S6K1 TSC2 TSC1 EGFR CCND1 CDK4 MTOR CDK6 PMC10845928__F1 Immunologic properties of cancer stem cells (CSCs) CD47 TRIB3 CCL5 CCL2 MTOR CEACAM1 SOX9 SIRPA TAP2 CHMP2A CSF1 HK2 TCF4 STAT3 PMC10845928__F2 Ferroptosis in CSCs GPX4 STEAP1 SLC7A11 CXCR4 FTL CXCL2 SLC3A2 PMC10845928__F3 Mechanisms underlying radio-resistance in CSCs ATM CDK2 RAD51 ATR ATG14 CCND2 STAT3 PMC10845928__F4 Mechanisms underlying chemoresistance in lung CSCs ROCK2 PAK1 POLR3G NOTCH1 BMI1 ABCG2 ABCB1 NFYA ALDH2 HES1 PMC7352359__F3 Current model of regulating the BRI1 abundance on the plasma membrane (PM) FLOT1 BAK1 SNX1 PMC3474103__F22 Diagram demonstrating the sites and mechanism of action of novel agents for the management of pancreatic endocrine neoplasm EGFR RAF1 MTOR PMC7232103__F1 Proposed mechanism for the synthesis of dihydroindoles from triazole 1a and rationalization of dihydroindole regioselectivity from sigmatropic rearrangements HEL70 PMC4043921__F4 Cytoskeletal proteins in cerebral cavernous malformation signaling pathways MYH9 KRIT1 MTOR SMURF1 OSM PDCD10 PMC8560953__F7 Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells REV1 POLN RAD18 PCNA PMC4784227__F4 Heme biosynthesis pathway UROD UROS CPO PMC7072620__F1 HMGB1/RAGE and HMGB1/TLR4 signaling pathways in AD: HMGB1 can interact with extracellular AB peptides and decrease AB deposition by inhibiting AB clearance by microglia, as well as increasing Beta- and Gamma-secretase activity HMGB1 GSK3B ACHE IL1B PMC10838448__F2 RANKL/RANK signaling pathway activates NFATc1 NFAM1 NFATC1 ANXA3 TRAF6 PPP1R18 HIF1A PMC368161__F7 Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor SET SCO2 AHR TWF1 FUS PAF1 PMC5354690__F1 FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification NOTCH1 RHO MTOR MEF2C PMC9710321__F1 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? NGF APC GSK3B TRPV1 STAT3 PMC9710321__F2 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? APC GSK3B TRPV1 PMC6398583__F3 Control of aerobic glycolysis by ERK and JNK signaling pathways in proliferating cells PARP14 BRAF MYC HIF1A HEL-S-133P PMC6398583__F4 ERK- and JNK-mediated phosphorylation of PKM2 is at the crossroad between proliferation and apoptosis PARP14 EGF PIN1 PMC4985055__F2 BMP signaling in bone GREM1 RUNX2 SMAD6 SMAD4 MAP3K7IP1 SMURF1 SMAD1 DKFZp781O1323 PMC4985055__F1 TGFB signaling in bone SMAD2 SMURF2 SMAD4 MAP3K7IP1 PMC7061838__F5 Relationships between GRHL2 and TGFB/MAPK signal pathways SMAD2 SMAD4 TF PMC6618030__F5 A suggested relationship between the defatting cocktail and intracellular lipolytic metabolic pathways APOB ACOX1 HEL-S-5 PMC8591115__F7 KRAS mutation: from undruggable to druggable in cancer HRAS MTOR IRS1 PMC8861005__F7 Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway BCL2 TG IRS1 PCNA PMC8591115__F2 KRAS mutation: from undruggable to druggable in cancer TIAM1 TBK1 EGF BAD MTOR CDC42 PMC7664983__F1 Action of Statins and Potential Interactions with Estrogen CYP2C9 CYP3A4 PMC11211395__F3 Dual role of sirtuins in cancer: biological functions and implications TDG SIRT6 PARP1 XPA ATR WRN SIRT1 BAX PMC6874216__F1 The biosynthetic pathway of ubiquinone (Q) in E COQ3 COQ2 COQ6 COQ5 IPP COQ7 PMC4899530__F14 Mechanism of Nrf2 activation by DMF and MMF and its role in neuroprotection MAF KEAP1 BACH1 PMC11211395__F2 Dual role of sirtuins in cancer: biological functions and implications SIRT4 SIRT6 MYC TFRC RPS15A SIRT3 PMC3481038__F2 Scheme demonstrating mechanisms used by natural compounds to drive changes in the epigenome PTEN PCNA PMC7224341__F1 Compartmentalization of adenosine biochemistry ADA AK1 PNP PMC3225948__F7 Three arms of the unfolded protein response stress-responsive signaling pathway ELF2 ATF4 XBP1 PMC2797439__F1 Class IA PI3K signalling pathway TSC2 PI3 FLCN TSC1 FNIP1 PTEN MTOR RHEB PMC4964535__F1 Mechanism and pathway map of the prostate cancer (modified based on KEGG database) BAD SOX2 HGF FRK CDK2 MDM2 CD44 BCL2 PTEN EZH2 PMC6138501__F1 Inflammasome activation and purinergic signaling in Chlamydia-infected cells TLR4 IL1B PMC9144571__F2 Whole Aspect of Runx2 Functions in Skeletal Development TNFSF11 RUNX2 opn COL1A2 IBSP DLX5 COL1A1 SP7 PTHLH BGLAP PMC9406852__F1 Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson’s Disease GPR157 NR1D1 PMC11598538__F3 Metabolites and DEGs in the biosynthesis pathways of fatty acid derivative and terpenoid in Oncidium Twinkle ‘Red Fantasy’ MVK IPP MVP PMC2826542__F1 An Overview of IL-7 Biology and Its Use in Immunotherapy GSK3B PTEN JAK1 BAX PMC2738133__F3 Molecular Aspects of Moraxella catarrhalis Pathogenesis HEL-S-62p C4B_2 VTN RAC1 CEACAM1 PMC5932236__F4 Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases SNAI1 KEAP1 FACL4 PPM2C PDPR CPT2 NNT CCL2 PDP2 LAG3 HIF1A HEL-S-32 HEL-S-5 HES1 MDH2 ACSL6 TNFRSF9 ACSL5 TNFRSF4 PC TNFSF14 C7 PDHA1 ACSL1 NOTCH1 OGDH SUCLG2 SDHD SDHB NOTCH2 PDHA2 SDHC XLKD1 APC VEGFA DLD CTLA4 PDC HEY2 PDK3 AXIN1 SUCLG1 HEL113 ACLY HEL-S-62p CS PDK2 CD48 JAG2 CD244 DLL3 NOTCH3 PDGFA FH DLL4 ACO2 DLAT CD68 FASN ME1 IL10 NOTCH4 DTX1 MMP9 NFE2L2 BTLA FGF18 PDK4 IDH3B MAGEA4 ACADL CPT1A LCK SAGE1 C6 CTAG1B CD80 CCL18 SUCLA2 CSF1 HES2 PDCD1 PMC6367587__F9 Schematic map describing apoptosis induction of the TRAIL and Andro combination therapy FADD BAX PMC3693544__F1 Transcriptional feedback in the insulin signalling pathway modulates ageing MED1 RPS6 SHC1 SGK1 PMC3693544__F2 Transcriptional feedback in the insulin signalling pathway modulates ageing EEF2K RICTOR TSC1 SIK2 PGC PTEN LPA RHEB PMC8645722__F8 G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor EGF EGFR GPS2 MTOR CBL PMC5390339__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 PMC4850838__F2 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease ANGPTL4 LPL APOC3 PMC9697024__F8 Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway SOCS3 STAT3 PMC7440669__F2 In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli ME1 ME2 LDHD PMC3102743__F7 Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin NODAL SOX17 FOXH1 PMC3674720__F1 The insulin-signaling pathway BAD FYN TRIB3 MTOR CRK IRS1 PMC8085803__F2 Immunoceptive inference: why are psychiatric disorders and immune responses intertwined? CRH TNF IFNG PMC4931134__F1 Disruption of miRNA biogenesis by estrogens and cigarette smoke can lead to oncogenesis EGFR MYC DROSHA PMC11012149__F2 Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease HMGB1 AIP HNRNPAB IGF1R MARCKS NLRC4 TRADD NLRP1 NLRP3 TLR4 HTT CAD AIM2 FADD MLKL PMC3891052__F3 Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome BRAF RPL22 PTPRK EGFR TGFBR1 NRAS MYC TRRAP PTEN CHD4 MTOR SIK1 CCNE1 NF1 NF2 PTPN1 MDM2 SRC SHH SMO GATA3 BAX PRKCI RUNX1 APC VHL ARHA RNF4 TNF HRAS TNLG7C FOXO1 BCOR EP300 MAX SUFU PSPH SPOP GNAS BRDT ATR SMC4 TRAF2 FADD PMC6929403__F2 The ceRNA networks involved in the chemokine signaling pathway CCL11 GNG13 CX3CL1 PF4 CXCL10 CXCL9 CXCL3 CXCL2 GNG11 PPBP PMC4969098__F3 Actions of IL-21 on T cells are context-dependent and shaped by cellular and environmental parameters STAT1 STAT4 MTOR IRF4 STAT3 PMC9021453__F6 Regularity of Toll-Like Receptors in Bovine Mammary Epithelial Cells Induced by Mycoplasma bovis IRF7 IRF3 MYD88 PMC5019180__F2 Complement-mediated regulation of metabolism and basic cellular processes CTSL HEL-S-62p C4B_2 CD46 BCL2 MASP2 C1S MTOR PMC2651433__F2 A nuclear SIRT1 mechanism for delaying NAD-ATP depletion through inhibition of PARP-1 is presented NAMPT NMNAT1 SIRT1 PMC7600363__F2 Biosynthesis and major signalling pathways activated by FLT3 wildtype (WT) (a) and FLT3 with internal tandem duplication (ITD) mutation (b) NOX4 FLT3 PMC6357151__F5 Differential Transcriptome Responses to Aflatoxin B1 in the Cecal Tonsil of Susceptible and Resistant Turkeys SST NMB GIPR GRPR GIP CCKAR VIP SSTR5 CCK PYY CHRM2 NPY2R GAL PMC2651433__F4 The Importance of NAD in Multiple Sclerosis PARP14 SIRT2 PARP10 PARP1 PARG PARP6 PARP4 PARP3 PARP16 PARP15 SIRT3 IFNG PARP8 SIRT7 SIRT4 PARP12 SIRT5 PARP11 SIRT6 PARP2 TRPM2 SIRT1 PMC6518944__F3 Metabolic dysregulation in GC‐derived B‐cell lymphoma IKZF1 PAX5 MYC HIF1A MTOR SIRT3 PMC6518944__F4 Aberrant BCR signaling in GC‐derived B‐cell lymphomas HEL-S-62p IKBKG TLR9 IRAK1 TRAF6 IRAK4 PTEN MYD88 MTOR BTK BCL10 BCR BASH CD19 TCF3 CD79B CD79A ID3 IKBKB NFKBIA CARD11 SYK HVCN1 TNFAIP3 NFKBIE PMC6797793__F1 A schematic of the tanshinone biosynthetic pathway IPP CP PMC8556920__F1 Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment IGF1R IGF1 HIF1A MTOR PMC5945668__F3 Contraction of smooth muscle cell: cellular pathway and the role of MYL9 and of other genes related to MMIHS RHO PMC7831272__F7 Proposed model on the epigenetic regulation mechanisms of histone H3K27 acetylation causing the FLHS in laying hens KIT ANGPTL4 TF FABP1 FGF7 PMC3328452__F8 Identification of Protein Networks Involved in the Disease Course of Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis TUBB NAPB ENO1 KCNMA1 NEFH NAPA PS1TP5BP1 TUBA1A HEL-S-269 APP HEL-S-66 ACTR3 PGAM1 C10orf27 PMC3671248__F7 Model for 20E regulation of IMD innate immune signalling DPT FADD PMC9002353__F7 mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder CREBBP GSK3B CCL5 MTOR PMC4529006__F1 Genes within the BDNF signaling pathway [adapted with permission from Macmillan Publishers Ltd CAMK4 FRS2 GRB2 SYN1 BDNF PDPK1 PMC10875059__F1 Metabolic pathway of risperidone CYP3A4 ABCB1 UGT1A1 PMC5653411__F1 Apoptosis and necroptosis as host defense strategies to prevent viral infection CGAS RIPK1 TRADD RIPK3 IRF3 FADD TLR3 MAVS MLKL BAX PMC8927965__F2 Dysregulation of Survivin-Targeting microRNAs in Autoimmune Diseases: New Perspectives for Novel Therapies PI3 SMAD2 PTEN TGFB1 E2F3 SFMBT1 STAT3 PMC10875059__F3 Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications CYP3A4 ABCB1 PMC6696086__F5 Signaling pathway regulating pluripotency of stem cells is modified during neural differentiation MAPK13 WNT4 BMP2 KLF4 APC2 FZD9 PMC6363687__F4 FGFR1 pathway promotes NFKB signaling FGFR1 TRADD MAP3K7IP1 TAB3 PMC2395193__F3 Gene networks identified in both recEbo-VP35/WT- and recEbo-VP35/R312A-infected cells compared to mock-infected and irradiated controls TANK FOS ENO1 RPL9 CTNNA1 CDKN2A HEL-S-68p SLC19A2 RASSF1 NARF KITLG PCBP1 TM4SF1 EMB SUPT16H PMC6412296__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention MCL1 FADD BAX PMC11476647__F1 Nrf2/Keap1/ARE signaling pathway BRF2 KEAP1 REST PMC3775564__F5 Molecular network analysis of the miR-200 family and potential molecular targets with Ingenuity pathway analysis (IPA) E2F4 HNRPA3 AGTR1 ZEB2 CTBP1 HFE BMI1 TFRC B2M TFR2 PMC3089921__F1 mTOR activation supports cancer cell survival CCND1 MTOR LAT PMC6993271__F1 Actions of metformin in eukaryotic cells ATF3 MTOR STAT3 PMC11476647__F2 Pathways influencing Nrf2 build-up and its downstream pathways KEAP1 GC PTEN PGAM5 PMC7026856__F1 [U-13C6]-glucose metabolism in the brain GIP CIT MAL PMC7581685__F2 Part of the innate immune signaling pathways triggered after the viral RNA is recognized by TLRs and RLRs TBK1 TANK STAT2 IRF7 TRAF3 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 TLR8 TLR7 TYK2 JAK1 MAVS PMC9684661__F2 Immunometabolism in the pathogenesis of vitiligo STAT1 CXCR3 CXCL10 CXCL9 PMC5137695__F5 Summary model of Tri-DAP activity and pathway utilization in HCMV-infected cells TBK1 NOD1 IRF3 RIPK2 PMC9684661__F1 Immunometabolism in the pathogenesis of vitiligo PDC CXCL16 CXCL10 CXCL9 PMC4013640__F2 Pericyte physical and biochemical interactions at the NVU TGFBR2 CDH2 PMC7279287__F1 Synthesis of butyrate in E HBD PMC2845642__F2 Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy LCK LAT PMC3672773__F1 Schematic presentation of select miRNAs that regulate toll-like receptor signaling pathways TBK1 TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRF3 IL6 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 MAL PMC1698636__F6 F igure 6.— CDC34 HMFT1766 PMC151039__F1 The classical pathway for bile acid synthesis begins with CYP7A1, which converts cholesterol into 7Alpha-hydroxycholesterol CYP7B1 CYP7A1 PMC3863339__F1 RACK1 signaling complexes CCND1 SRC BAX PMC3286973__F2 Cell-line subtypes have unique SuperPathway network features EIF4A1 MAPK9 FOXM1 RUNX2 MYC GCG E2F3 XBP1 CCND2 POLR3D ZFP36 CAMK4 KLK3 SHH HEL-S-44 CDK4 MSH2 VCAN PISD FOXA2 APOB MAP2K1 MAX BCAT1 TFF1 VTN SKP2 PMC3286973__F3 Pathway diagrams can be used to predict response to therapies CHEK2 EREG CASP6 ERBB4 PLK3 ATM ERBB2 ERBB3 TP63 GADD45A CHEK1 BCL6 PMC11064802__F7 Action of carbohydrates in atherosclerosis therapy ABCG8 ABCG5 NPC1L1 MYD88 MTOR NR1C1 PMC11064802__F1 Action of TCM prescriptions and natural bioactive molecules in atherosclerosis therapy by targeting peroxisome proliferator-activated receptors (PPARs) TLR4 CPT1A ABCG1 MYD88 ABCA1 NR1C1 ACOX1 CD36 PMC4831128__F6 Ingenuity Pathway Analysis (IPA) of cholesterol and bile acid metabolism genes NPC1 ABCG1 ABCA1 NR1H3 PPARG NR1C1 APOE RXRA PMC3186046__F1 S1P receptor subtype-specific heterotrimeric G protein coupling and intracellular signaling mechanisms S1PR2 S1PR1 S1PR3 RHO PTEN PMC9519310__F7 Interaction of the IFNG/JAK/STAT1 and JAK/STAT3 Signalling Pathways in EGFR-Mutated Lung Adenocarcinoma Cells STAT1 EGF EGFR STAT3 PMC2654418__F6 Crosstalk between the Androgen Receptor and Beta-Catenin in Castrate Resistant Prostate Cancer LEF1 TCF3 LYN GSK3B MYC YES1 CTNNBIP1 TCF4 PMC8520212__F5 The tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor? SIRPA CD47 HP TIGIT CEACAM1 PMC2663816__F1 Single-Cell Profiling Reveals the Origin of Phenotypic Variability in Adipogenesis RS1 HEL-S-11 DES PMC12150179__F2 Influence of ROS induced by microplastics on macrophage metabolism, function, and polarization CGAS GPX4 RIPK3 TFRC CCL2 MTOR GSDMD NLRP3 COX2 ATM CD163 CD40 NOS2 CD36 PMC12150179__F3 Microplastics indirectly affect macrophages by disrupting gut microbiota COX2 TLR4 CCL2 PMC8470673__F1 High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats ADA ACE2 HYI PMC5104457__F1 ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis RIPK1 RIPK3 MLKL CPD PMC5354977__F1 Interplay between immune checkpoint proteins and cellular metabolism CD80 CTLA4 HIF1A MTOR HEL-S-133P PMC5292326__F1 Functions of natural IgM in homeostasis maintenance and autoimmune diseases prevention; (A) sIgM enhances apoptotic cell clearance BCR CD5 PREB PMC8615588__F1 Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs EGF NRG3 ECD EGFR ERBB3 NRG2 NRG1 ARHA ERBB4 ERBB2 GRB2 TGFA NRG4 PMC6753603__F2 Schematic overview of the two most common pathways with genetic alterations in thyroid cancer—mitogen-activated protein kinase (MAPK) and phosphatidylinositide 3-kinase (PI3K) pathways NF1 TSC2 RET TSC1 FGFR1 ALK FGFR3 PTEN MTOR FGFR2 PMC8256363__F9 Novel lncRNA promotes myogenesis of bovine skeletal muscle satellite cells via PFN1‐RhoA/Rac1 ARHA RAC1 PFN1 PMC5293166__F4 Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy BACH2 CCR7 PTEN FOXO1 IFNG SELL FOXP3 PMC9465037__F2 Bacterial cyclic di-adenosine monophosphate in the host immune response NLRP3 DDX41 IRF3 PMC10706706__F6 DEGs expression pattern diagram of JA biosynthetic pathway in mustard leaves after beet armyworm larvae chewing AOC2 PMC6450927__F10 Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A NLRP3 TLR4 TXNIP MYD88 PMC6407289__F11 Model for Pyk2 action in AD risk ROCK2 FYN ABO ARHA PSD PMC9520111__F2 TNFIFN-induced necroptosis CASP3 TRADD RIPK3 TNF IFNAR1 TRAF2 FADD ZBP1 MLKL PMC7555743__F7 Schematic diagram showing the signaling pathways involved in anti-inflammatory effects of the combination of ginsenosides Rg2 and Rh1 in macrophages STAT1 TLR4 IL1B PMC8882979__F1 Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs APC LRP5 LRP6 ROR2 ROR1 PMC5470107__F2 Interconnected processes of (i) S1P synthesis and degradation within the sphingomyelin/salvage pathway, (ii) S1P export and (iii) signaling through binding to five specific G-protein-coupled receptors, S1PR1-5 S1PR2 opn SPP2 S1PR1 S1PR3 S1PR5 SPHK1 RHO S1PR4 SPNS2 SPHK2 PMC5638182__F2 Mongersen, tofacitinib, filgotinib: mechanisms of action SMAD2 JAK3 PMC6265005__F1 Tumor necrosis factorA pathway for necroptosis RIPK1 TRADD RIPK3 TNF TRAF2 FADD MLKL PMC8127406__F7 Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses CHCHD10 FGF21 GDF15 MTOR XBP1 CHCHD2 HTRA2 CLPP PMC8296533__F1 Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment PDGFC FGF2 PDPN CCL28 CXCL12 CSF1 PMC4677515__F1 Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos SETD3 CRISP3 CASQ1 CRYBA2 HEL-S-57 POSTN NTHL1 HSPA2 NRAS GNG7 HNRNPL CNNM2 AMPD1 CRYBB1 MKS1 AHNAK HSPD1 SPAG1 NOL11 CCL1 MAP2K6 CENTA2 HSD17B10 PYGM HEL-S-66p CCR1 MDH2 GDI2 HEL-S-278 UQCRC1 CCL24 KRT4 HEL-117 ME3 FPR1 IL8RB DCHS1 YWHAQ SNAPIN TRH LAMTOR1 AVP ADCY6 CLTC RRAGA CCL22 GNB1 AK1 SUMO1 NPHP1 NME2 GNGT1 TTN EEF1G UBC RPS5 PKP1 CCL17 ACO2 CXCL6 ATP6V1A HMGB1 INPPL1 SNAP91 INVS RASD2 CCDC14 MEF2B SLC38A9 KRT7 MSTN ATP2A1 DKFZp686L24211 HEL-S-87p CYTIP HP1BP3 TGFBI USP1 PMC2629585__F7 Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response HEL-S-62p CRP C1S PMC6355880__F8 Model describing the distinct fates of NK cells during NK cell education PI3 HEL-S-11 PIKFYVE PMC7564754__F4 How selected polyphenols can interact with p57 expression and activity (see and text for details) EGR1 CDKN1C PCNA PMC7278812__F3 Selenium-dependent antioxidant system of glutathione peroxidases (GPx) and thioredoxin reductases (TrxR) GPX4 GPX1 PMC8101358__F1 Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome SPTLC1 GDE1 SGPP1 ABHD4 SPTLC2 SPTLC3 FAAH DEGS1 PTPN22 SGPP2 PMC7564754__F3 Selected polyphenols that interfere with p27 expression and activity (see and text for details) CDK2 CDKN1B SRC PMC4940708__F8 Mechanism of the disease-modifying effect of P021 in AD GSK3B APP BDNF PMC6010716__F3 Genes predicted to increase cardiovascular angiogenesis are strongly up‐regulated by CpG pre‐conditioning 24 h post‐I/R ITGAM SET CFB CEACAM1 ITCH PMC8204760__F3 Non-G-protein signaling at 5-HT receptors CDK5 APP SRC CDC42 PMC8204760__F4 Constitutive activation of 5-HT6 receptors by different GPCR-interacting proteins (GIPs) NF1 CDK5 GIP MTOR CDC42 PMC9425441__F7 Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V PC ADAMTS13 VWF PMC4085546__F2 KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma MMP9 VEGFA SMO PMC8473645__F8 Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis NR2F2 GPX4 GSTM1 PMC6747935__F2 How insulin-stimulated cleavage of TUG and subsequent trafficking of GSVs coordinately regulates multiple physiologic effects USP25 HEL-S-61 IRS1 PMC6370335__F2 Intercellular and intracellular signals that initiate liver regeneration EGF HGF HBEGF TGFA IL1B STAT3 PMC12026336__F1 RSV infection induces TLR signaling CD14 TLR4 TRAF6 PMC4256331__F11 The signaling pathways affected by Syk that drive AB production, neuroinflammation, and Tau hyperphosphorylation BACE1 GSK3B SYK PMC7988780__F3 Is nuclear sirtuin SIRT6 a master regulator of immune function? SIRT6 MYC GLS PMC3876437__F1 A non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis IFNGR2 JAK1 IFNGR1 PMC5000752__F7 Simplified representation of canonical and non-canonical Hedgehog(HH) signaling HHIP SUFU PTCH1 GLI3 SMAD4 SMO MTOR PMC3000843__F1 Schematic representation of chiral 3HV production via the threonine biosynthesis pathway in metabolically engineered E HBD THRA PMC10520719__F11 ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer SOX2 SOX3 HSP90AB1 LRP5 CCND1 FZD7 LRP6 SMAD1 ADAM11 DKFZp781O1323 BMP4 PMC5000752__F6 Androgen receptor (AR) signaling pathway GRB2 SRC PMC9682156__F1 Autophagy and the primary cilium in cell metabolism: What’s upstream? FLCN SMAD2 MC4R MTOR PMC2491599__F2 Wnt canonical signaling pathway MMP7 APC MYC CER1 WIF1 JUN PMC3415084__F2 Impact of placental insufficiency on endocrine responsiveness in fetal myoblasts and myofibers IRS1 PMC8307885__F2 Nano-Strategies Targeting the Integrin AvB3 Network for Cancer Therapy CBY1 SRC CASP2 CEACAM6 PMC2491599__F3 Wnt signaling pathwhay in cervical cancer ROCK2 NLK FZD3 APC PMC5546324__F5A AKT/PKB Signaling: Navigating the Network TSC2 TBC1D7 COIL RHEB PMC8995861__F3 Oxidative RNA Damage in the Pathogenesis and Treatment of Type 2 Diabetes NUDT5 NUDT15 NUDT18 PMC9307784__F4 Orbital fibroblasts (OFs) in acute and chronic TED IGF1R TSHR CD40 PMC8970309__F2 Overcome Drug Resistance in Cholangiocarcinoma: New Insight Into Mechanisms and Refining the Preclinical Experiment Models APC ABCG2 PMC3133937__F1 Concerted regulation of the WNT-DVL-GSK3B signaling pathway in NAc by chronic social defeat stress PROP1 WNT4 AXIN1 AXIN2 PMC8850271__F1 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease CYP27A1 GCA CYP7A1 PMC8850271__F2 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease FGF19 FGFR4 CYP7A1 PMC4493455__F2 Schematic overview of ligand-stimulated SR signal transduction FYN SRA1 LYN CD36 PMC8861487__F2 Innate Immunity in Natural Elite Controllers of HIV-1 Infection TLR8 CGAS TLR7 TLR4 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC11915864__F9 RNF20 demonstrates dual regulation of the chicken MDA5-IFNB signaling pathway by targeting chMDA5 (created using Figdraw) TBK1 RNF20 IRF7 MAVS PMC3986510__F1 Ceramide de novo synthesis pathway CERS3 LASS1 CERS5 CERS2 CERS6 PMC3986510__F4 Diagram demonstrating sites of interference by various small molecule agents or genetic ablation of enzymes engaged in ceramide and sphingolipid synthesis pathway CERS3 LASS1 CERS5 CERS2 CERS6 PMC6194161__F1 TLR and CLR interactions with helminth-derived products NLRP3 TLR4 SYK HEL-S-92n MYD88 TLR3 PMC8508851__F13 Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey ATM MDM2 PTEN PMC3613056__F7 Pathway scheme of baicalein on the cell proliferation inhibition and cell metastasis inhibition in human bladder cancer cell 5637 MMP2 MMP9 GSK3B CCNB1 CCND1 PMC3688269__F2 Dysfunctional telomeres activate upstream checkpoint PI3 kinases, such as ATM (ataxia-telangiectasia mutated) or ATR (ataxia-telangiectasia and Rad3 related), - () ATM CDK4 ATR CDK6 PMC3513735__F3 Most enriched molecular networks showing interactions between the significant genes (according to SAM)—(a) FOSB, ERK, MAPK3, CYR61, and the RAS-genes; (b) DUSP1, ERK1/2, P38MAPK, DUSP9, and RASD1; (c) CYR61 and NFRKB dik NCK2 TSC22D3 DUSP9 SHE RHOV SSBP2 SLC25A4 GRB7 SP100 OSMR RHOU C21orf58 VEGFC EDC4 NFRKB ARHGEF5 ZFP36 BCR FOSB TRAM2 PACSIN2 RHOB PMC5421758__F2 Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models CLTA CD46 MLPH TBCB PITPNB STAT1 SBF1 NR1i1 CDYL SAFB FRS2 MTSS1 ATXN2L HTT ZNF710 NOTCH1 GDPD2 MAPK1 KLHDC2 USP22 PIGO NONO BARD1 MMP14 VAMP2 MED16 AIMP2 MAEA PPP2CA TNS1 U2AF2 MPL NFKBIE EGF BTRC COPZ2 PTN XPO7 DST SNRPG RHO PRKCSH ELAVL1 PAPOLA FOXA1 STS GABARAP XPOT NPPA WNK1 PFKL TRIM26 EFS NUP153 EP300 MAP2K1 NDUFB4 PKNOX1 OGA STUB1 OGT TWF1 HNRNPC LYN RNP24 PECR TRIM28 WDR37 GNAS HEL-S-93 RNF10 POLM PMC2711321__F2 Wiring diagrams for a three-module decomposition of the intrinsic apoptotic pathway HEL-S-62p C9 BCL2 BAX PMC11240800__F2 Abnormal signaling pathways contribute to the pathogenesis of uLMS SUFU GRB2 SRC SMO PMC7564554__F7 lncRNA–mRNA co–expression network INAFM2 PMC6430781__F5 Sub-network of the innate signaling pathway obtained after IPA analysis of the differentially expressed genes in A549 lung epithelial cells infected with WM 06.482 conidia CS ZFP36 BCR MAFF MAFK RELB PIGS JUNB PMC4433221__F5 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode STAT2 IRF9 PIAS1 JAK1 IFI35 IRF-1 PSMB8 BAX PMC2267714__F3 Gene expression changes detected in selected pathways in M group CDR2 ATR PCNA PMC4433221__F6 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode ADAR ENPP1 OAS2 RSAD2 EPCAM STAT2 IRF9 IRF3 UBA7 BPI MX1 PMC9298548__F3 Comparative Transcriptome Analysis Reveals the Mechanism Associated With Dynamic Changes in Meat Quality of the Longissimus Thoracis Muscle in Tibetan Sheep at Different Growth Stages TSC2 F2 PDK2 INS MTOR SIRT1 RHEB CFTR INSR CD36 PMC6612360__F1 Endothelial dysfunction and angiogenesis impairment in the ageing vasculature IGF1 PARP11 MTOR SIRT1 PMC7651862__F8 Our working model in this study MMP7 LEF1 TWIST1 GSK3B CD44 CCND1 PTEN TRIM37 TCF4 PMC5819357__F1 Combinatorial CRISPR-Cas9 metabolic screens reveal critical redox control points dependent on the KEAP1-NRF2 regulatory axis GCK PFKM HEL-S-32 MDH2 GOT2 PC HEL-S-278 PDHA1 PKLR RPIA PDHX PFKP RPE DLAT PGAM1 HEL-S-133P HK2 PGAM2 HEL-S-281 MAL ME1 PDHA2 ALDOB ENO3 HK3 FBP2 ME2 ENO1 DLD PFKL HEL-S-87p HEL-S-162eP HEL-S-68p HEL-S-49 H6PD ENO2 HEL107 PMC8804062__F1 Neurobiological Opportunities in Diabetic Polyneuropathy BAD SEMA3A ARHA CDK4 PTEN RB1 MTOR CDK6 BAX PMC5852779__F2 TLR2, TLR4, and TLR5 signaling pathways TBK1 TLR5 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR3 PMC6326689__F3 Molecular pathways modulating lifespan via control of the translation machinery ELF2 TSC2 EEF2K TSC1 LARP1 ATF4 EEF2 EIF4E RPS6 EIF4B RHEB PMC8874935__F3 Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome? ZAP70 USP9X RHO RAC1 SOCS1 CDC42 PMC3334407__F5 Schematic model for inhibition of cell proliferation by EGCG analogs TSC2 TSC1 MTOR PMC6594015__F6 Schematic depiction PDK2 MTOR IRF6 PMC4915230__F1 Cell signaling pathway through which DD complex elicits a balance between survival and programmed cell death RIPK1 TRADD CYLD RIPK3 TNF TRAF2 FADD TAB3 PMC12223915__F6 Serum Pharmacology Combined with Network Pharmacology Reveals the Effects and Mechanisms of Ganmai Dazao Decoction in the Treatment of Depression NPY SHE OXT VIP RAI1 PMC4051765__F1 Responses of the Insulin Signaling Pathways in the Brown Adipose Tissue of Rats following Cold Exposure TSC2 BAD VAMP2 SOCS3 GRB2 PTEN EIF4E GRB10 MTOR CRK CBL PMC9559204__F8 Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense TFEB MTOR PMC7700034__F7 Schematic outline representing the acute effect of AB (1-42) on cholesterol dyshomeostasis-induced neurotoxicity and its possible protection through quinovic acid BACE1 CASP3 KEAP1 GFAP IL1B SYP HMGCR BAX PMC7830632__F1 Apoptosis, inflammation and endoplasmic reticulum (ER) stress regulated by the caspase family TMEM214 AIM2 BAX PMC3658451__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity TLR8 TLR5 CARD9 TLR7 TLR4 TLR9 BCL10 TLR1 NOD2 TLR3 PMC7830632__F2 Response model of Ras/phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway to the growth factors, amino acids and glucose levels RICTOR SH3BP4 PTEN EIF4E MTOR ECHS1 IRS1 RHEB PMC7723170__F1 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 PMC5021946__F4 Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways CTH HEL-S-182mP MGLL AGK AGXT GLDC AGXT2 DGKA PMC6429193__F1 JAK2-STAT5-SOCS pathway and domain structure of STAT5 PAK1 EPO OGA OGT SRC RHO COIL MTOR CDK8 PMC4808242__F1 Obesity-linked metabolic pathways susceptible to diet induced epigenetic perturbation TH LEP POMC ST8SIA4 SLC6A3 SETDB1 NNMT CEBPA MBD2 PPARG CDKN1C FASN PMC7764689__F3 Ingenuity pathway analysis (IPA) network analysis of the modified proteins in response to BK 48 h stimulation relative to control in RASMC HEL-S-102 TNC CAV2 HEL113 RPS6 HEL-S-130P PXN PMC3745259__F1 The hexosamine biosynthetic pathway provides the donor substrate for O-GlcNAcylation and other types of protein glycosylation PGM3 OGT PMC316921__F6 Wnt signaling in the early C. elegans embryo APC POP1 PMC3745259__F2 O-GlcNAc is involved in the cellular stress response OGT GSK3B GPX1 SP1 MAP3K7IP1 HSF1 PMC4369723__F5 Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B STAT1 EGF EGFR GRB2 SP1 TGFA STAT3 PMC8304542__F2 Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer PIGF VEGFC VEGFD VEGFA VEGFB PMC11394487__F5 AMPK signaling pathway EEF2K ULK1 EEF2 CPT2 MTOR EIF4EBP1 STRADA HMGCR RPTOR CFTR MLST8 TSC2 TSC1 HNF4A STK11 CCND1 STIM1 FASN PMC8873123__F3 Autophagy plays a double-edged sword role in liver diseases HMGB1 ATG12 MTOR ATG9A DKFZp686F0183 TGFBI PMC8288800__F5 Long noncoding RNAs in metastasis site-specific tropism CCL2 STAT3 NSUN6 PMC11394487__F6 ERK/MAPK signaling pathway RAPGEF1 BAD BRAF MOS NFATC1 FOS LAMTOR3 DOCK1 EIF4E EIF4EBP1 CRK CRKL STAT1 RPS6KA1 KSR1 PTK2B SRC DUSP2 PPARG SHC1 PXN ARAF PMC6070639__F2 PA induces the upregulation of PGC-1A expression via multiple signaling pathways NRF1 IGF1 GPX1 PGC MTOR TFAM PMC8288800__F3 Long noncoding RNAs regulate metastasis via various pathways using diverse mechanisms ITGB4 ZEB2 GSK3B MYC TCF7L2 JARID2 EZH2 MTOR FOXA2 PMC4149521__F4 Gene Expression Profiling Reveals Epithelial Mesenchymal Transition (EMT) Genes Can Selectively Differentiate Eribulin Sensitive Breast Cancer Cells EGF EDNRA HGF CFB FGF2 EGFR NOTCH1 ARHA SP1 PS1TP5BP1 PMC7578566__F3 Cellular senescence by extracellular matrix during chronic fibrotic diseases CYR61 EBP SMAD2 APC SMAD4 RAC1 PMC11394487__F7 PI3K/AKT signaling pathway BAD HEL2 SFN PTEN EIF4EBP1 MTOR PDPK1 MDM2 CCND1 HEL-S-28 CDKN1B MAP3K5 CDC37 EIF4E RHEB LIMS1 TSC2 TSC1 CDKN1A GAB2 GRB2 BCL2 MCL1 RAF1 MAPK8IP1 SHC1 PMC4763954__F1 Fas:FasL interactions TRAF1 FADD PMC7432812__F2 Schema for the mechanisms for different types of cell deaths GPX4 BAD LPCAT3 TRADD RIPK3 BMF GSDMD TRAF2 FADD MLKL HRK BAX DFNA5 PMC11394487__F2 Mitochondrial biogenesis pathways PPRC1 TFAM TF PMC5295669__F2 Modes of DNA synthesis POLE POLK RAD52 RAD51 PCNA PIF1 PMC8288800__F6 Long noncoding RNAs and tumour microenvironment HNRNPL CCL2 PMC8490516__F8 Kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis TFRC ICOS FOXP3 PMC11953055__F8 Schematic illustration summarizing the mechanism by which NSUN2 promotes colorectal cancer (CRC) CUL4B EGFR NSUN2 STAT3 PMC4452855__F2 Types I and III IFNs canonical signaling pathways IFNA1 IFNA4 STAT2 IRF7 IRF3 IFNAR2 IFNAR1 IFNLR1 USP18 ISG15 IFNA2 TYK2 SOCS1 PMC9305279__F1 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 ULK1 TFEB ATG12 ACE2 PMC9305279__F2 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 ULK1 ATG12 VPS39 STX17 VAMP8 ACE2 SNAP29 TMEM41B VMP1 PMC6895510__F1 Regenerative abilities contribute to the application of BM-MSC in psychocardiological disease FOXC1 F2 GFAP NOTCH1 VWF FOXC2 PMC9015857__F10 Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis PLCG1 GRB2 SYK MAPK1 LAT PMC6996643__F2 Meta‐analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis IL10 CD14 NFKBIA TLR4 LBP DEFB1 IRF3 MYD88 TNFAIP3 TIRAP PMC8534037__F2 Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities HGF SMAD2 GSK3B SMAD4 PMC5752239__F9 The putative mechanism involved in the transdifferentiation from SESCs to CECs NEUROD1 DKK1 DOCK9 PMC11475022__F6 GSEA of 18 patients with CTEPH from the GEO database TH CYBA TNFRSF12A EBP ARHGEF12 CENPF CRAT CPT2 SSH2 STARD4 PTS HEL-S-278 COL1A2 SURF1 NIPBL DLAT SMS SDHA MRPS15 TRIO MAL MRPS30 APC HMGCS1 POP1 HEL-S-87p CNTRL GUSB FADS2 SMC3 FHL2 ABCC1 CEP250 ACADM PMC7736044__F1 Interplay between cysteine protease activation and mitochondrial deteriorating processes in MS myelin degeneration LAMP2 PMC3887753__F1 Sequential pathway leading to renal ischemia-reperfusion injury CCR5 IL8RB PMC2695499__F10 Changes in OSM signaling TYK2 IL6ST JAK1 OSM OSMR STAT3 PMC12199726__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections ChAT SPIB PLCG2 TRPM5 IL25 PMC3532050__F1 NFKB inhibition by A20 in the TNFR1 signaling pathway RNF11 TRADD TRAF5 RELA TNF TRAF2 ITCH PMC3376977__F2 NK cells sense tumors, course of disease and treatments STAT1 HLA-G BCR VHL IFNG PMC8309156__F1 Behind the Adaptive and Resistance Mechanisms of Cancer Stem Cells to TRAIL ABCG5 FADD BAX PMC8419687__F2 IL‐4‐induced changes in metabolism and their effects on gene expression EIF5A ARG1 IRF4 CD36 PMC9082817__F7 Transcriptomic Profiles of Splenic CD19+ B Cells in Mice Chronically Infected With the Larval Echinococcus granulosus MFGE8 CD9 CD46 POSTN IFITM2 ALOX12 NRIP3 IL1R1 COL1A1 IFITM1 OSMR STAT1 CFH COL1A2 COL6A1 CD55 STEAP4 CDH2 TGFBR3 CD14 GM2A ITGA2B CYP1B1 PDGFRA CD63 PF4 CD34 SULT1A1 GPX3 MMP14 LILRA6 AGPAT4 ENPP2 F5 NFIL3 ITGAV MPL PMC514582__F10 Schematic of Nef signaling pathways and their relationship with Nef’s biologic effects in podocytes SRC MAPK1 STAT3 PMC11484033__F6 Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway LATS1 LATS2 PMC12153738__F4 PGRN’s multifaceted roles in lysosomal function, autophagy, and metabolism impacting cardiovascular health SOCS3 TFEB IL6 CD36 PMC3847559__F5 Combining DC vaccination with immune checkpoint blockade CD80 PMC12153738__F3 Progranulin (PGRN) in vascular pathophysiology SORT1 TLR4 VCAM1 EPHA2 SMAD1 DKFZp781O1323 PMC5784573__F2 Radiation effects on antitumor immune responses: current perspectives and challenges HEL-S-62p HMGB1 C5AR1 CGAS CXCL16 TLR4 ATM VCAM1 CD80 CCL2 C3AR1 PMC5968744__F1 Schematic representation of the signal transduction pathway of ATF3 protecting against I/R-induced inflammation, apoptosis, or myocardial injury in various organs ATF3 HDAC1 TF PMC4982433__F3 Signalling pathway and targeted therapy in gastric cancer KMT2C KMT2A HGF PTCH1 SMO RAF1 EZH2 MTOR FGFR2 PMC7485092__F2 Innate and adaptive immune responses in SARS-CoV-2 Infection IL10 IL22 CXCL3 IL6 CCL2 IL4 IFNG PMC8670437__F7 In situ Metabolomics of Metabolic Reprogramming Involved in a Mouse Model of Type 2 Diabetic Kidney Disease HDC pcap PMC2874622__F2 The Role Of Mitochondria In The Mammalian Antiviral Defense System MFN2 NLRX1 UQCRC2 MAVS PMC9140097__F1 Chromosomal Instability in Chronic Myeloid Leukemia: Mechanistic Insights and Effects BCR GC SSB PMC8002454__F1 Rheb-mTORC1 signaling pathway in neurodegeneration BACE1 TSC2 ULK1 TSC1 TBC1D7 MTOR RHEB MLST8 PMC2722250__F2 Silent chromatin assembly in budding and fission yeast CHP2 CHP1 ARC PMC8637215__F7 Cytokine and Complement Response in the Glaucomatous BB1-CTGF Mouse Model HEL-S-62p CXCL1 CFB CFD CXCL10 CXCL2 PMC12024285__F12 1-DNJ alleviating OS in porcine GCs MFN2 ATF4 PGC MCU BAX PMC2707511__F6 DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition MDC1 EME1 RAD50 ERCC1 MRE11A BRCA1 TDP1 PMC9524011__F2 Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis HEMGN EGF NUPR1 LIF WNT1 EGFR PTEN TF STAT3 PMC3183400__F4 New Insights into insulin resistance in the diabetic heart SOCS3 IRS1 STAT3 PMC8231807__F1 FGFR Inhibitors in Oncology: Insight on the Management of Toxicities in Clinical Practice BRAF CYP24A1 FGF19 MTOR PMC5226550__F7 Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes CSK SRC PTEN PMC4779427__F6 DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States OLR1 MYPN MAP2K4 APOD TCF7L2 HSPB8 HIF1A IGFBP5 ISL1 EGLN3 BMPR2 CDKN1A BMPR1A ABCC9 NCF1 APOE NCF2 PMC7310212__F1 Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma TSC2 TSC1 IGF1R IGF1 LATS1 RHO PTEN EIF4E MTOR RHEB PMC4955846__F1 Toll-like Receptors, Triggering Receptor Expressed on Myeloid Cells Family Members and Receptor for Advanced Glycation End-products in Allergic Airway Inflammation IRAK1 GRB2 TRAF6 SYK IRAK4 STAT3 PMC6944218__F5 PCB153 exposure altered forkhead box O (FOXO) signaling pathway EGF IGF1R ATG12 EGFR PDK2 RAG1 SMAD4 PTEN RAG2 INSR NLK PRMT1 ATM CDK2 GRB2 IL7R KLF2 BNIP3 STAT3 PMC9086899__F4 BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications BMPR2 ATF2 SMAD4 MAP3K7IP1 SMAD1 TF DKFZp781O1323 PMC6479341__F1 The role of unfolded protein response (UPR) in cell survival upon induction of ER stress ATF4 EIF2A PMC2677752__F1 Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development IL16 ENG HOXA5 PMC6050934__F7 NOX4/TRPC6 pathway is important in podocyte calcium regulation and renal damage progression in diabetic kidney disease TRPC6 NOX4 ROS1 PMC11015223__F9 OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS–STING pathway to mediate GBM immune escape OMA1 BNIP3L BNIP3 PMC4223653__F2 Neurology of mTOR NF1 TSC2 EGF ULK1 TSC1 IGF1 GSK3B TBC1D7 PTEN BDNF RHEB PMC4223653__F3 Neurology of mTOR NF1 TSC2 ULK1 TSC1 PTEN ULK2 MTOR PMC8137566__F7 Activation of Wnt/Beta-catenin signaling pathway induced by cooperative activity of ALK and N-Myc LEF1 PTN ALK DDX3X hCG_2014051 PMC11489333__F8 Positive feedback for self-driving of NK-92AFR-CAR-CXCR3A cells based on IFNG and TNFA synergistically induced high CXCL10 expression STAT1 CXCL10 IFNGR1 PMC6787556__F4 NAD+ Depletion and Impaired Mitophagy Are Pivotal Events in Common Neurodegenerative Diseases BACE1 NAMPT NMNAT2 CDK5 PARP1 SARM1 BDNF FUS HEL-S-162eP PMC8282409__F2 New Insights on the Early Interaction Between Typhoid and Non-typhoid Salmonella Serovars and the Host Cells NLRP3 GBP1 NAIP TLR4 NLRC4 TLR10 PMC5372489__F2A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus SOCS2 PRKCE SLC2A2 SOCS4 INS IRS1 INSR PMC6787556__F1 Nicotinamide Adenine Dinucleotide (NAD+) Production and Catabolism in Mammalian Cells NAMPT NADK NNMT NMNAT3 SLC22A3 SLC36A4 SLC12A8 NAPRT HEL-S-90n NMNAT1 KYNU NMNAT2 SARM1 PMC9284792__F11 Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway YTHDF2 POLR2A HEL-S-34 RAF1 UBE3C ACD PMC8160143__F8 Bacterial and viral induced expression of IL22 IL1A IL7 IL22 IL6 IFNB1 SAA1 TNF PMC9164251__F1 Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19 STAT2 IRF7 IRF9 MDM2 IFNAR2 IFNAR1 ACE2 PMC536026__F1 Schematic of the Gp1 mGluR/FMRP pathway PTEN ADRBK1 PMC4671457__F5 A, B) Functional analyses of target genes of the differentially expressed miRNAs in MAPK signal pathway CD14 INA EGF MOS TRAF6 TNF SPN FAT4 NLK MAX ECSIT RAF1 TRAF2 LTK JUN PMC6441662__F5 Fibroblast growth factor receptor 4 signalling pathway in cancer FRS2 GRB2 FGFR4 PMC7141219__F3 Upstream network analysis of the proteins from endothelial cells exposed to ponatinib and Notch-1 signaling inhibition NFKBIA NR3A2 FOXO3A RELA JUN PMC3663815__F7 Pathway summary of peptide array and antibody array results TSC2 BAD TSC1 BRAF INS PTEN EIF4E MTOR IRS1 FOXO1 RHEB PMC7641573__F5 Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway CDH2 PMC9321501__F3 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer CHEK2 PML CDC20 PLK1 PSMC6 NEK2 MCM10 PXN GABARAP MYLK KIF11 PMC6600399__F2 Regulation and role of the PI3K-AKT-mTORC1 pathway in ribosome biogenesis and translation initiation EEF2K LARP6 LARP1 MYC PTEN DEPTOR RHEB TSC2 POLDIP3 ELF3 MAX MDM2 MAF1 RPS6 EIF4B PMC8667978__F1 Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects PDC TLR7 TLR4 CS TLR9 TF PMC9321501__F5 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer PLK2 SOCS2 KIF23 PLK1 SOCS3 SGOL1 BIRC5 INCENP STAT5B AURKA CDCA8 AURKB KAT7 PRC1 ECT2 CDC6 PTK2B KIF20A GINS2 CENPU KIZ C13orf34 MYLK PMC5577045__F8 Signaling pathways altered by XWL-1-48 ATM MDM2 H2AX BAX PMC8722763__F6 Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway CDC2 CDH2 STAT3 BAX PMC3937030__F1 MTOR pathway signaling pathway PC EEF2 MTOR ELF4 EIF4B PMC2728865__F2 Transcriptional Regulation of Metabolism Associated With the Increased Desiccation Resistance of the Cactophilic Drosophila mojavensis PDC HEL-S-162eP PMC6045671__F1 Hippo pathway YAP1 NF2 VGLL4 STK4 LATS1 WWTR1 LATS2 FRMD6 PMC10670380__F3 Multi-level functional integration of extended regions of the human genome, above and beyond individual noncoding RNAs NONO APOE PMC5441763__F5 CD19 is the linchpin between CXCR4, the BCR, and the actin cytoskeleton CXCR4 SYK CXCL12 FOXO1 CD19 PMC12110894__F7 Expression changes of key enzyme genes for flavonoid synthesis pathway in different light treatments MVD FDPS BIN2 PMC3988961__F3 Pathway analysis MAF GBP1 EGR1 SCARB1 ZNF365 TRO PID1 ATF3 JUND LPA GAST JUN PMC4732882__F1 Metabolism and the circadian clock converge NAMPT SIRT1 PMC8997905__F2 Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases NLRP3 TLR4 FPR1 SYK SARM1 TNF IL1B NOD2 PMC11498046__F4 Preparation of PGRsEV-siYTHDF1 YTHDF1 SIRPA CD47 FZD7 IFNG PMC10564423__F8 Schematic diagram illustrated how core fucosylation regulated alveolar epithelial cells senescence in pulmonary fibrosis through TGFB/Smad2/3 pathway in vivo and in vitro BLM SMAD2 PMC5360546__F4 Hippo pathway LATS1 PMC9480797__F3 Molecular pathways in glioblastoma-derived stem cells to identify effective drug agents: A bioinformatics study KIF23 CCNA2 MYBL2 FOXM1 CDKN2C CENPE TOP2A DBF4 AURKA ECT2 KIF18A CCNB1 NEK2 KIF20A DKC1 CENPN KIF15 C13orf34 SMC4 NEK9 CENPA TERT PMC7409586__F1 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency NCL EEFSEC SEPSECS TRNAU1AP SEPHS2 PSTK RPL30 EIF4A3 PMC4547750__F4 Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases DUSP14 CDC25B TNF MTOR DUSP3 DUSP7 PMC2735600__F7 Contribution of Rho to canonical Wnt3A signaling WNT3A APC GSK3B LRP5 LRP6 ARHA PMC10996135__F6 Distribution of common targets in the two most associated pathways MYB CD14 BAD CD37 TRADD GCK PTEN EIF4E TNF RHEB TSC2 NLK MAX BCR MDM2 GRB2 SYK ECSIT EIF4B RBL2 CD19 PMC6356823__F2 Predictive pathway for polyamine synthesis in microalgal cells DAP SMS PMC7409586__F3 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency MCM5 GC SELE PMC11868327__F3 Molecular cascade of the involvement of GluD2 or GluRD2 in cerebellar cell death PC DKFZp686F0183 BAX PMC6828590__F13 Regulatory mechanism of the VEGF signal pathway in different groups COX2 BAD PIR CASP9 SRC CDC42 PMC4420611__F5 Lysosome pathway UTY LAP3 ABCA2 PMC6828590__F11 Regulatory mechanism of the PI3K-AKT signal pathway in different groups BAD MYC GIP PTEN MTOR TLR4 BCR MDM2 CASP9 CCND1 GAL EIF4B RBL2 CD19 CDC37 RAC1 EIF4E IRS1 BRCA1 RXRA TSC2 TSC1 HEL164 GRB2 SYK PMC6828590__F12 Regulatory mechanism of the MAPK signal pathway in different groups CD14 EGF SRI NGF MOS FLNA ATF2 EGFR TRAF6 TNF NLK NF1 PAK1 PC MAX JUND ECSIT BDNF TRAF2 MEF2C PMC7952883__F3 General mechanisms of sildenafil in different types of cancer ABCC1 ABCG2 MTOR ARG1 ABCB1 PMC4336821__F7 Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis RARB CDK4 RBBP8 RXRA CCND2 PMC6745167__F2 Results of network analysis: differentially regulated proteins from the SILAC approach are indicated in green (TCam-2) or in red (NTERA-2) TH ALPL EGF GGH IGF1 LEFTY1 BCAM ERBB2 ERBB3 EGFR SHE PYGB PMC5354081__F1 Examples of Metabolic Pathway Linking Gut Microbiota to Cardiovascular Diseases NLRP3 CYP27A1 CYP7A1 CD36 PMC11727624__F1 Biological processes of the canonical Hedgehog (Hh) signaling pathway HHIP HP SUFU SMO KIN ADRBK1 PMC4854486__F1 Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis NALCN GIPR GIP PMC5460031__F10 IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression MAML1 CXCL1 TRAF5 NOTCH1 TRAF6 CCL7 STEAP4 S100A9 TRAF2 IL17RC PTX3 CP PMC3155635__F3 Functional pathway analysis of the 12-gene genomic instability signature using Ingenuity Pathway Analysis IL10 MYB CASC3 MYC TNPO2 RBM8 HCTP4 TNF CDKN2A CCND3 AURKA MUC4 FOXA1 CCNB1 CASP9 BCL2 CD40LG CDK4 CCL18 TF TERT PMC7754529__F3 Co-expression pattern of the most significantly enriched pathways of differentially expressed genes involved in post-traumatic stress disorder TBK1 EGF IKBKG CHUK GNG13 EGFR MAPK8IP2 CRKL TAOK1 INSR PRKCA PTPN11 NTRK2 PTPN5 RAB5A FGF12 NFKB1 DUSP16 GRIN2B PIK3CA MAP3K8 RAF1 SOS1 TGFA DUSP8 DUSP7 PMC8160963__F1 Identifying Novel Actionable Targets in Colon Cancer BRAF APC TGFBR2 SMAD4 DCC IGF2R BAX PMC3082499__F5 Anti-apoptotic mechanisms of Akt TSC2 BAD TSC1 MDM2 MTOR RHEB BAX PMC8160963__F2 Identifying Novel Actionable Targets in Colon Cancer BTRC APC GSK3B TNKS TRRAP BCL9 PAF1 PMC8160963__F3 Identifying Novel Actionable Targets in Colon Cancer SMAD2 TGFBR1 SMAD4 PMC4126409__F1 Pathways for HJ Resolution(A) Resolvases RuvC and GEN1 digest HJs to generate linear products with single nicks (carets) GEN1 SLX4 EME1 PMC3082499__F2 Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling TRADD TNF FADD PMC321458__F8 Model of the role of RNase MRP in cell cycle control CIB2 APC XRN1 PMC8301371__F8 TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors CCR5 TLR7 TYK2 MYD88 JAK1 TRAF2 STAT3 PMC7461042__F2 HIF1 signalling pathway EGF EPO VHL IL6 TFRC HEL-S-87p HEL-S-133P TF HEL-S-162eP PMC6454084__F1 Putative palmitoylated proteins of the mechanistic target of rapamycin (mTOR) signaling pathway NPRL2 C16orf35 FLCN DEPDC5 SEH1L MIOS TBC1D7 WDR24 MTOR RPTOR RHEB MLST8 TSC2 TSC1 WDR59 PMC3116244__F1 Signaling Pathways Altered in Hepatic Cancer Stem Cells BAD EPCAM IGF2 APC GSK3B PTEN MTOR ADAM17 LEF1 CDX2 FHL2 CCND1 IGF2R STAT3 TERT PMC6535055__F9 The mechanism graph of the regulatory network of PIEZO2 under different circumstance including normal (A) and cancer (B) CDON PIEZO2 PMC6839745__F1 Structure and treatment strategy of TAT-CLs-DHA/siRNA HMGB1 TLR4 MYD88 IL1B PMC7835870__F1 Metabolic conversion pathway from the essential omega-3 PUFA, ALA, to longer-chain omega-3 PUFAs, EPA, DPA and DHA FADS2 ELOVL5 FADS1 ELOVL2 PMC8280825__F1 Mitochondrial apoptosis pathway and opportunities for pharmacological inhibition NLRP3 CGAS PNPT1 OPA1 BAX PMC8137978__F1 Ferroptosis in Acute Respiratory Distress Syndrome GPX4 SLC7A11 GLS2 SLC3A2 PMC8553038__F2 Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases CD9 CD63 SMAD2 MMP9 TSPAN8 PTEN TSPAN6 CD81 HEL-S-162eP TSG101 CD151 MMP2 WNT4 CXCR4 SIRT1 STAT3 PMC6177564__F2 Schematic illustrations of identified pathways in hepatitis C virus-induced liver carcinogenesis PMC3093193__F2 Update on the regulation of mammalian melanocyte function and skin pigmentation EDN1 KIT POMC EDNRB HGF NGF NGFR DCT TYRP1 NRG1 MC1R SOX9 PMC8315846__F6 MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture PTGIS IRAK1 HEL-S-1 TRAF6 IRAK4 MYD88 PMC5561186__F8 Schematic overview of effects of metformin on gene expression and metabolism in human adrenal H295R cells, focused on mitochondria and steroidogenesis ENO3 ACSS1 COX6B2 ENO2 ABCA1 PCK2 CYP17A1 STAR UCP2 PMC5576886__F1 Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases FEN1 NEIL2 POLE MBD4 TDG NEIL3 LIG1 MUTYH UNG OGG1 PCNA NEIL1 PMC3025761__F1 Schematic illustration of the various steps involved in the ubiquitin proteasome pathway and general architecture of the cullin 1 (CRL1) and cullin 4 (CRL4)-based E3 ubiquitin ligases SKP1 RBX1 DDB1 PCNA PMC2769052__F9 Schematic representation of a potential mechanism of IFN-Gamma- and STAT3-dependent cell growth modulated by TSC2/mTOR signaling pathway TSC2 MTOR IFNG STAT3 PMC7352671__F2 Sorafenib resistance CYP3A4 EGFR PMC7123108__F2 Cordyceps militaris adenine metabolic pathway ADA NT5E PNP ADK PMC6785598__F4 Epigenetic regulation of stem cells PRC1 ME2 TDG KLF4 TET2 POLI PMC8184806__F6 SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions HEL-S-102 ATF1 TNF PMC4880867__F1 Fzd7 receptor complexes and signalling output ZNRF3 WNT3 RNF43 SDC4 LRP5 LRP6 RYK ROR2 PMC11360101__F7 Cytoscape shows the interactions between 9 major components of CSAEs and 4 known kidney injury pathways TRADD DAO ROCK1 RIPK3 ARHA RAC1 MTOR RYR2 TLR3 STIM2 PLN RIPK1 TLR4 OMD TRPC3 TRAF2 ORAI1 FADD STIM1 CDC42 PMC5549368__F1 Checkpoint inhibitors in melanoma and early phase development in solid tumors BRAF CTLA4 PMC3227454__F2 Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function KRI1 EGF EGFR INS INSR PMC6485421__F1 NFKB and tumor-associated macrophages IRF7 CXCL10 IRF3 MYD88 NOS2 ARG1 PMC4328972__F1 Metabolic disturbance in the diabetic heart and prospective therapeutic targets NLRP3 TLR4 NR1C1 PMC3391966__F1 Model of hedgehog action in the fetal male reproductive system DHH PTCH1 SF1 SHH PMC2778015__F3 Master regulator miRNA of oncogenic and tumor suppressor TP53INP1 AATF ATM MDM2 BCL2 CCNE1 PMC6065152__F2 Pancreatic cancer microenvironment participates in metastasis CXCL1 TLR4 CX3CR1 SHH CXCL8 QSCN6 STAT3 PMC5677514__F1 Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme PIGF PIGC PIGN PMC3592971__F3 Four simplified signaling pathways MAPK9 SOCS3 SMAD2 TGFBR1 GSK3B MYC SMAD4 DKK1 MTOR FZD1 BMP8A DVL2 LEPR CSNK1A1 SP1 APC SMAD6 AMHR2 LRP6 CAMK2G ATP2A1 HTR5A ADCY8 IRS1 IKBKB TNFRSF1B CDKN2B AXIN1 GNAS TRAF2 SMAD1 TGFB1 STAT3 PMC5085707__F1 Stages of cancer cell colonisation of the bone CASR VCAM1 VTN CXCR4 IL11 CXCL12 CDH2 PMC11836306__F1 TORC1 pathway in humans and yeast, derived from Refs3,19 FLCN NPR2 DEPDC5 CASTOR2 MIOS CASTOR1 WDR24 KICS2 DEPTOR RHEB MLST8 TSC2 TSC1 NPR3 WDR59 FNIP1 SZT2 ITFG2 PMC3328638__F1 Glucose, fatty acid (FA) and glutamine metabolic pathways TIGAR HEL107 HK2 PMC6335266__F1 Simplified representation of the complement system, divided into pattern recognition molecules (PRMs), pathway specific and common components as well as inhibitors HEL-S-62p CD59 C9 CD46 C4B_2 VTN C7 C6 CD55 C4A PMC7443478__F9 Sensitization of glutamate receptor‐mediated pain behaviour via nerve growth factor‐dependent phosphorylation of transient receptor potential V1 under inflammatory conditions NGF AKAP5 TRPV1 PMC7593681__F9 Potential mechanism of HBO treatment on intestinal barrier after SCI ROCK1 RHO PMC10796096__F1 cGAS-STING signaling pathway in amyotrophic lateral sclerosis (ALS) TBK1 CGAS SQSTM1 HNRNPA2B1 HEL-S-44 IRF3 C9orf72 VCP OPTN PMC7664196__F3 Autophagy, Ca2+ and cancer ATG16L1 MTOR ATG14 ORAI1 STIM1 PMC7664196__F2 Apoptosis and Calcium (Ca2+) dynamics in cancer PML APAF1 MCU PTEN MCL1 FADD BAX BAP1 PMC4136471__F2 Cellular and molecular interactions between HCL cells and their microenvironment BTK BCR CXCR4 MSC CD44 CD40 SYK CXCL12 PMC8632547__F3 Hippo Signaling Pathway: The Trader of Tumor Microenvironment TEAD3 CXCL1 CXCL5 IL8RB TEAD4 CCL2 TEAD2 PMC8632547__F4 Hippo Signaling Pathway: The Trader of Tumor Microenvironment TEAD3 SRC TEAD4 LATS1 RHO LATS2 TEAD2 PMC8632547__F1 Hippo Signaling Pathway: The Trader of Tumor Microenvironment NF2 TAOK3 VGLL4 LATS1 MOB1A TAOK1 TAOK2 PMC8632547__F2 Hippo Signaling Pathway: The Trader of Tumor Microenvironment SRC LATS1 RHO LATS2 PMC6304368__F7 Anti-HBV mechanism of TLR3 signaling of HSCs STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 HEL-S-70p TLR3 STAT3 PMC6034666__F2 Engagement between the gut immune system and a probiotic (exemplified by Bifidobacterium longum subsp PDC TLR9 CCL20 PMC8632547__F5 Hippo Signaling Pathway: The Trader of Tumor Microenvironment APC ROR2 LATS1 RHO LATS2 ROR1 PMC3481450__F6 Overlapping network between MCF-7 and ZR-75.1 cells LCMT2 TIAL1 PMF1 ENY2 VPS37D TF PMC4429670__F1 Vicious cycles in bone metastasis SOST DKK1 MTOR PMC8095092__F2 Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: emphasis on ponatinib BAD BCR GAB2 GRB2 BCL2 BAX PMC6123311__F3 Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins POMC SOCS3 SH2B1 PMC7519200__F3 Innate immune system is the first line of defense against infection and injury and plays critical roles in the maintenance of brain homeostasis NLRP3 IL16 SIRT1 PMC5679168__F1 Contribution of BBB breakdown and dysregulated BBB transport to AD pathophysiology based on findings in animal models, as shown in and VLDLR PICALM PMC11046441__F3 Diversity of metabolic arrangements for Alpha-glucan and disaccharide pathways in the context of prokaryotes GC KIN MAL PMC3514351__F1 Ingenuity pathways analysis summary LIPE PRF1 HEL-S-107 LAG3 PENK HYOU1 PCSK2 CP PMC6497837__F1 Schematic showing mechanisms underlying morphine tolerance NLRP3 TRAF6 NEUROD1 JUN TRPV1 PMC4094071__F8 AEG-1 regulation of HIV-1 neuropathogenesis IL18 YY1 TNF PMC7526653__F1 2HG metabolic pathway HEL-S-26 HEL-S-133P PMC6686482__F7 Schema presented the mechanism through which NOTCH1 aerobic glycolysis and signaling in PC cells were modulated by MACC1-AS1 MMP9 NOTCH1 PAX8 PMC11576191__F1 CaMKK2 signaling pathway GHSR CAMK4 CAMK1 CAMKK2 PMC8826371__F7 Graphical representation of the possible mechanism by which the stat4 genetic polymorphism affects HCC STAT4 TG FGL2 CYP2E1 PMC9194156__F2 Neurodevelopmental disorders, immunity, and cancer are connected IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TNF TIRAP STAT3 PMC9194156__F5 Neurodevelopmental disorders, immunity, and cancer are connected FRS2 GRB2 MTOR DEPTOR PMC5794698__F1 Major communication pathways of the microbiota–gut–brain axis CCK NPY PYY PMC7526653__F3 Cystathionine metabolic pathway CTH PSAT1 SHMT1 PSPH HEL-S-51e PHGDH PMC3525110__F3 Proposed model for EA signaling CORT MVK RAC1 PMC5778870__F1 Interaction of miRNAs as oncogenic and tumor suppressor PTEN HRAS PMC2935335__F1 The highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer RET BRAF PTEN MTOR PMC4183711__F8 Diagram depicts a model in which Eya2 and Ebf3 are positioned in the gene regulatory pathway for the development of RGCs HES5 ATOH7 EYA2 SOX11 EBF3 ONECUT1 ISL1 SOX4 POU4F2 HES1 PMC6646339__F7 Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke IGF1 MTOR PMC4755325__F1 CGAS-STING Defense Pathway and Its Counteraction by Viruses CGAS IRF3 MYD88 AIM2 MAVS PMC4755325__F2 The cGAS-STING Defense Pathway and Its Counteraction by Viruses TBK1 CGAS ULK1 RNF5 RNF26 TRIM32 TRIM56 IRF3 PMC9296991__F1 Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations TLR4 SOCS3 NOS2 PMC4769158__F11 Proposed mechanisms by which loss of TRAF2 in keratinocytes causes a psoriasis-like skin inflammation REL TNF TRAF2 PMC8431333__F5 Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression SUFU ARHA ARHGEF17 PMC9404709__F2 Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells SIRT1 AMT SIRT3 PMC3903161__F1 Steps of autophagy pathway activation ULK1 ATG12 ATG3 ATG101 MTOR ATG14 DKFZp686F0183 PMC4325706__F3 Pathway Express analysis of the host response to IBDV infection in the spleen CASP3 BAD EPO TRADD ATM CASP9 TNF FADD PMC4325706__F4 Pathway Express analysis of the host response to IBDV infection in the bursa BCL10 BCR DAO BOLL CD19 PMC6939687__F2 Interplay between HIF-1A and Notch during hypoxia NAMPT SOX2 NRARP CP PMC4327822__F5 mGluR1/5 signaling pathways relevant to protein synthesis ELF2 EEF2K TSC1 EEF2 PDK2 RAF1 EIF4E MTOR RHEB PMC6781639__F2 VEGFR structures and their specific ligands PIGF VEGFC NRP1 VEGFA VEGFB NRP2 PMC8771846__F7 RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways PAK4 TNF PMC6989995__F1 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating cell cycle and cytokine-cytokine receptor interaction CDK2 CA14 TRO TNF TNLG7C ORC3 PCNA SKP2 PMC6989995__F2 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating TLR signaling pathways and enhancing the apoptosis pathway ME1 ATM MAFK TEP1 IRAK4 CAD TRAF2 HTRA2 FADD PMC8129546__F2 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway IGF1R THBD MAPK3 MYC MAOA CCL5 CCL2 MTOR MMP3 GNB3 IL18 XDH ABCG2 CASP8 ADIPOR1 IL10 FABP2 PON1 NR3C2 IL6 TNF HAS2 NR1C1 CASP3 RELA GH1 HTR2A PPARG SIRT1 PMC10474119__F9 Mechanistic diagram summarizing the regulatory effect of TGR5 in mitochondrial dysfunction and neuroinflammation in Müller cells TBK1 CGAS PC IRF3 PMC8910147__F1 CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives CXCL1 CXCR1 FOS CXCL5 CXCL10 CXCL8 CXCR5 IL8RB CXCR6 CXCR3 PDC CXCL16 CXCR4 CXCL9 CXCL12 ARG1 CXCL11 PMC5727324__F6 DKK1–CKAP4 axis as a novel molecular target for cancer therapy and future perspectives DKK3 CKAP4 DKK1 DKK2 DKK4 PMC5727324__F4 DKK1 and CKAP4 signalling axis CKAP4 DKK1 PMC6295421__F5 Proposed mechanisms of nitrergic neurotransmission in the SIP syncytium PDGFRA VIP PMC5727324__F2 Polarized trafficking of Wnt proteins and receptors WNT3A WNT1 LRP6 RYK ROR2 DKK1 PMC5727324__F1 ‘Two endocytic routes and two outputs model’ in the Wnt signalling pathways WNT3A APC LRP6 ROR2 DKK1 TCF4 PMC10505339__F2 NFKB signalling pathway RUNX2 LTB RELB TNF PMC10706418__F5 Analysis of hormone signaling transduction in response to CGMMV infection BAK1 BIN2 EBF2 TF PMC3091762__F9 IPA representation of the complement system pathway enriched in cluster 6, 3 hours post-infestation with P CD59 C4B_2 C7 C6 CR2 C4A CR1 PMC10505339__F4 BMP signalling pathway SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC3091762__F7 IPA representation of the canonical pathway for leukocyte extravasation signalling in cluster 4, 24 hours post-infestation with P HEL-S-11 TEC RHO CRK PMC1570177__F1 Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability CASP3 HEL-S-62p C9 APAF1 CASP9 CASP8 BAX PMC5659885__F2 Stretch-induced actomyosin contraction in epithelial tubes: mechanotransduction pathways for tubular homeostasis VASP SRC ARHA PMC8416109__F5 Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds EGFR GRB2 PMC9213757__F1 Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways RNF168 RIF1 BARD1 MRE11A BRCA1 L3MBTL1 SMARCAD1 PMC7832239__F1 Crosstalk between complement and coagulation cascade in COVID-19: There are 3 major self-regulating and overlapping pathways of complement activation system HEL-S-62p C9 C7 C1S PMC2956119__F1 This figure shows the two distinct but ultimately converging apoptosis signaling pathways in mammals CASP3 APAF1 CASP9 FADD BAX PMC5595129__F1 An overview of roles of miRNAs as a regulator of DDR in response to radiation in cancers ATM BRCA2 SSB RAD51 ATR H2AX BRCA1 PMC2956119__F2 The many roles of FAS receptor signaling in the immune system BCR CD40 PMC9503463__F2 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity MAVS PMC6553925__F6 Summary of all identified phosphosites in LPS signaling pathway TBK1 CD14 TNIP2 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR4 IRAK3 TRAF2 TIRAP TAB3 PMC11395329__F6 MiR-27a-5p functions in hDPCs TLR4 IRAK1 RELA FSTL1 TRAF6 IRAK4 MYD88 MAP3K7IP1 PMC9503463__F1 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity NLRP3 TRAF3 IRF3 NOD2 PMC8129546__F8 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway NLRP3 GSDMD BAX PMC2373983__F1 Human T-Cell Leukemia Virus Type 1 Blunts Signaling by Interferon Alpha ISG15 GBP1 STAT2 IRF9 IFNAR2 IFNAR1 IRF-1 PMC2956119__F3 The many roles of FAS receptor signaling in the immune system CASP3 APAF1 CASP9 FADD PMC4149467__F6 GATA regulation of Notch signaling in the intestine ATOH1 MUC2 FABP1 LCT PMC8080387__F5 Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63 TP63 GSK3B PTEN PMC10505339__F1 Interaction of Wnt/Beta-catenin and Wnt/Ca2+ signalling pathways in an inflammatory environment NLK LRP5 LRP6 PMC8173139__F1 Radiotherapy and Cytokine Storm: Risk and Mechanism NLRP3 CXCL16 TLR9 FPR1 CXCR4 CCL5 IFNG PMC3064629__F6 miR-34a, MAGE-A genes, and p53 form a positive feedback loop modulating chemosensitivity in cancer cells MAGEA12 MAGEA2B MAGEA6 MAGEA3 PMC5733474__F2 Enriched PI3K/AKT signaling pathway, identified by Ingenuity Pathway Analysis based on 300 differentially expressed genes (nominal P values < 0.05) detected exclusively in both week 8 and week 12 topiramate (TPM) groups TSC2 HEL-S-125m CCIN BAD RRAS PTEN MTOR PPP2R5D RHEB NFKBIE PMC6727394__F1 Altered metabolic pathways and associated circRNAs in cancer HEL-S-133P GLUD1 FASN HEL-S-5 GLS PMC6727394__F2 circRNAs and the Warburg effect associated signaling pathways IGF1R APC GC VEGFA BCL2 MTOR STAT3 PMC7140961__F3 Metabolic pathway based on phenolic profiling CAD ACD PMC2575728__F2 Following the cytokine signaling pathway to leukemogenesis: a chronology EPOR LCK IL2RA JAK3 JAK1 REL PMC4066644__F2 Model of tumor heterogeneity PTCH1 SHH SMO PMC2583327__F10 Transcriptional and Translational Regulation of Transforming Growth FactorB Production in Response to Apoptotic Cells ARHA EIF4E MTOR PMC6199573__F1 Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A E2F4 E2F6 BRAF HEL2 HEL-S-1 EGFR E2F3 CCND2 SMC1A MAP4 ATM E2F2 CCNB1 HDAC2 CDK4 MCM10 YWHAG PTTG1 CCNE2 FOS APC E2F5 CDC45 MCM3 CCNB3 PTTG2 EP300 MCM2 BUB1B CCNB2 ATR PRKCH TGFB1 PCNA SKP2 PMC6721639__F1 After interacting with CD154, CD40 recruits and interacts with several adapter proteins, including TRAF1, 2, 3, 5 and 6 MEI1 TRAF5 RELA RELB CD40 IL6 CD80 MAPKAP1 PMC7334537__F1 Steroidogenesis including the classic androgen pathway (dark blue) and the alternative androgen biosynthesis pathway (light blue), both resulting in the synthesis of potent 5Alpha-dihydrotestosterone (DHT) SRD5A2 POR CYP17A1 CYP21A2 PMC8423434__AF1 Principles of signaling pathway modulation for enhancing human naive pluripotency induction RBPJ LIF SRC PMC5646231__F1 Regulation of Exercise-Induced Autophagy in Skeletal Muscle PINK1 ULK1 FUNDC1 ULK2 BNIP3 MTOR PMC151063__F9 p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop DDR1 MDM2 BAX PMC6332791__F9 A proposed model underlying the OTUB2/U2AF2 axis as an activator of the Warburg effect and tumorigenesis in NSCLC cells OTUB2 U2AF2 MTOR HEL-S-68p PMC6060714__F6 Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway BRCA2 RAD52 RAD51 BRCA1 PMC3529366__F6 BMP2-WNT4-FOXO1 pathway in HESC differentiation DCN SST WNT4 BMP2 LEFTY2 BCL2L11 SMAD1 FOXO1 DKFZp781O1323 PMC4999430__F1 Interplay between EPEC/EHEC and inflammasome NLRP3 NLRC4 FADD PMC8437142__F10 Morphine-induced inhibition of moderate acute intermittent hypoxia-induced phrenic long-term facilitation (pLTF) TLR4 NACA BDNF PMC9622720__F4 Network exploration of gene signatures underlying low birth weight induced metabolic alterations BAD CD37 MEI1 MYC PTEN RAC1 IRS1 BRCA1 RHEB TSC2 BCR MDM2 SYK GAL RBL2 CD19 PMC8585600__F1 Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications TLR9 POR ACE2 STAT3 PMC5485083__F2 Top Left: Gene expression networks activated whilst differentiating cells are treated with varying doses of escitalopram ANK2 RPL32 DNTT DPF3 DST PWP2 DLG4 PTPRN GNL2 DCAF13 TNFRSF21 CKAP2 BMS1 PMC9308265__F8 Chronic heat stress promotes liver inflammation in broilers via enhancing NFKB and NLRP3 signaling pathway NLRP3 TLR4 IL1B PMC8524770__F3 Sex hormones in lung cancer CXCR4 CXCL12 PMC8524770__F4 Sex hormones in lung cancer EGF HRG IGF1 MTOR PMC4279092__F2 Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis EBI3 CD63 MTOR STAT3 PMC3874419__F4 Cross-talk of EGFR/HER2 signaling with other pathways EGFR GSK3B PTEN HES1 PMC10705939__F2 Schematic diagram of the regulatory pathways of K+ channels or transporters in Arabidopsis and rice BAG4 HDAC10 PMC5890100__F2 Whenever there is any inflammatory stimulus to the cell, there is activation of several molecular cascades such as NFKB, Nrf2, MAPKinase, JAK/STAT, p53, PI3K/mTOR, CREB, and Wnt/Beta catenin BAD KEAP1 RELB JUNB MYD88 CSA2 MTOR BAX PMC5601168__F1 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy APC GSK3B LRP5 LRP6 PMC5601168__F2 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy PKP2 NF2 GSK3B CCND1 PMC3759561__F1 Regulation of Muscle Protein Synthesis and the Effects of Catabolic States TSC2 TSC1 IGF1 GSK3B PMC6265603__F3 Altered PI3K/Akt pathway during normal and insulin resistance OGA OGT PTEN PMC8688947__F1 High-Fat Diet-Induced Renal Proximal Tubular Inflammatory Injury: Emerging Risk Factor of Chronic Kidney Disease NLRP3 CCR2 TLR4 HDAC3 IL33 CHAC1 MYD88 MTOR TGFB1 CD36 PMC6265603__F1 Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer IGF1 OGT IGF2 PTEN RPTOR PMC6769682__F5 Receptors used by chemerin, visfatin, resistin and apelin for their signaling pathways CMKLR1 DCN CCRL2 ROR1 PMC9001126__F7 Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway BAK1 MSC MMP9 PMC8963304__F8 Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons HGF AGTR1 ACTA2 NOX4 PTEN TMSB4X NOTCH1 CCND1 CDK4 DDX5 SP1 ITGB3 FGF2 CD34 VEGFA PTH RAC1 HRAS ITGB1 MAP3K7IP1 NFKBIA EDNRA EDNRB TIMP1 CDK2 GRB2 ITGAV PMC3569837__F2 Understanding metabolic regulation and its influence on cell physiology TIGAR KEAP1 F2 PFKFB4 PMC5930454__F8 miR-135b upregulated in BLBC represses multiple genes ROCK2 BAMBI INVS E2F4 NODAL SMAD2 TGFBR1 APC SOST NOTUM SMAD6 SMAD4 SKP1 ARHA RBX1 LTBP1 IFNG FST NLK DAAM1 RAE1 PMC8232957__F1 Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy MMP9 CCR7 IL8RB LAG3 XBP1 CD36 PMC5735743__F3 MTG16, and other MTG family members, may play a role in the constitutive repression of both Wnt and Notch signaling pathways MYC NRARP TCF4 PMC4816337__F1 Quantitative Modeling of the Alternative Pathway of the Complement System HEL-S-62p CD59 FH C7 C6 CR1 PMC5661630__F3 ZIP-mediated signaling pathways promote cell proliferation and metastasis in luminal and tamoxifen-resistant breast cancer cells EGF EGFR GSK3B SRC STAT3 PMC6151767__F27 Asymmetric aldol/lactonization sequence for the synthesis of spirooxindole dihydropyranones 93 BOC SI NBN PMC2217489__F4 F igure 4 PTEN MTOR RHEB PMC5661630__F2 Zinc deficiency in prostate cancer cells promotes cell survival via a phosphoinositide 3-kinase (PI3K) signaling pathway CDK4 PTEN PCNA PMC3864108__F1 Schematic diagram showing the interaction between NW arenaviruses and host innate immune response TBK1 TRAF3 IRF3 MYD88 TLR1 MAL PMC6626595__F2 Biosynthesis pathway of sialylation ST6GAL2 GNE ST3GAL3 ST8SIA4 ST8SIA5 ST8SIA6 ST8SIA2 ST8SIA1 ST3GAL6 SIAT4C ST6GALNAC6 CMAS NANS ST6GALNAC4 ST3GAL1 ST6GALNAC2 NANP ST6GALNAC1 ST6GAL1 ST3GAL5 PMC8770421__F2 Versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function BMP6 BMP2 SMAD6 SMAD4 ENG SMAD9 BMP4 BMPR2 ACVR2B BMP10 ACVR2A SMAD1 DKFZp781O1323 PMC6147150__F2 Pathway and network analyses showing major cellular processes associated with persistence of BD PRR11 IQGAP3 PLK1 DUSP19 TXN DEPDC1 IFNL2 DSC3 KRT4 CKAP2L PTK6 UACA SPRR3 TMPRSS4 JARID2 STAP2 DGKA KRT3 KIF18B EIF6 DIXDC1 GTSE1 CP CDC42 PTGER2 KIFC1 TMOD2 KRT23 AQP3 NUF2 PRC1 PKP1 TUBA1C KNTC2 PKP3 DSG3 LETM1 TEF IL17A NPL KRT5 KRT10 KRT14 TICRR MPDZ STXBP4 TNFRSF19 HCTP4 AURKA IL7 TREM1 HEL164 ZWINT HEL-S-81p PMC3607076__F3 ATM controls cellular survival in response to DNA damage through multiple pathways ATM MDM2 PMC12215033__F7 Schematic pathway illustrating the potential effect of curcumenol on Fc epsilon receptor I signaling BTK FYN GAB2 LYN SYK PMC3607076__F4 Selected summary of the ATM signaling network RIF1 ATF2 MDC1 TSC2 RNF168 RNF8 RNF20 ATM ATMIN HMGN1 CEP63 ATR H2AX PMC3983448__F4 Human epidermal growth receptor family members, the PI3K/Akt pathway, and targeted drugs COX2 IGF1R EGFR CCR4 PTEN MTOR PMC3042643__F1 EGFR signaling pathway EGFR GRB2 PTEN PMC3983448__F2 Molecular pathway for microsatellite instability+ gastric cancer PIK3CA HDAC2 XPO5 ARID1A TARBP2 BAX PMC2739295__F6 Gene Expression Profiling in Cells with Enhanced Gamma-Secretase Activity SIAH1 PTPRG opn GSK3B PROC LRP5 CD44 LRP6 ARHA HEL113 PMC7774932__F7 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus NR1C2 HEL-S-104 PPARG NR1C1 PMC8282058__F6 Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment BACE1 IGF2 APP IGF2R PMC7774932__F8 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus NR1C2 HEL-S-104 NR1H3 PPARG NR1C1 PMC3580541__F5 TRAF6 and TRAF2/5 signaling pathways TRAF5 TRAF6 CSA2 TRAF2 PMC7318778__F2 Dendritic cell metabolic reprogramming in tumor immune evasion IDO1 MSR1 HEL-S-53e XBP1 PMC3898101__F8 Separate PI3K and Wnt signaling pathways APC AXIN1 PMC8387852__F5 Gold nanoparticles enhance microRNA 31 detection in colon cancer cells after inhibition with chlorogenic acid SOX2 CGA BAX PMC3697618__F7 Diagram illustrating the phagocytic signaling pathway initiated by TLR4-linked JAK2 activation during the internalization of B CD14 TLR4 LBP CDC42 PMC5282884__F7 Illustration of interaction between NRIP2, RORB, and HBP1 NRIP2 CCND1 RORB RORA AXIN2 TCF4 PMC7358640__F1 Main calcium signaling pathways through Ca2+ channels and transporters involved in the regulation of calcium homeostasis in mammalian cells TRPV4 CA11 MCU ORAI3 TRPM7 STIM2 TRPM8 TRPC4 TRPC1 TRPM6 TRPC6 TRPC3 TRPV6 ORAI1 STIM1 PMC10831399__F3 NRP-1 gene expression generating axis of stem-cell properties LIN28B NRP1 PMC6099543__F7 Proposed biosynthetic pathway for nine ginsenosides F2 RB1 ARAF PMC4237243__F4 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways BRCA2 RAD51 CDC2 H2AX BRCA1 BAX PMC12020991__F9 Schematic diagram of the molecular mechanism of PEDV hijacking CD4+ T cells for migration to the intestinal mucosa RAC1 CDC42 MADCAM1 PMC4888492__F1 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle BAD IRS4 PDK2 PTEN IRS1 FOXO1 CBL TSC2 TSC1 FYN IGFBP1 GRB2 RPS6 AKT3 PMC4888492__F2 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle IGFBP1 GRB2 PTEN MTOR TGFA IRS1 AKT3 PMC5665080__F2 Metabolic reprogramming associated with immune cell activation engages the mevalonate pathway ACLY MTOR PMC5665080__F3 Inflammatory and immune responses to mevalonate pathway dysregulation IL16 MVK IPP PMC5665080__F1 SREBP-driven mevalonate pathway PMVK MVD ACAT1 FDPS MVK HMGCS1 ACLY IPP PDSS1 HMGCR PMC4237243__F5 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways BRCA2 RAD51 CDC2 MTOR H2AX BRCA1 BAX PMC4053348__F1 Role of MALT1 in signaling to NFKB in ABC DLBCL BTK CARD11 BCL10 BCR CYLD IRAK1 PYY SYK IRAK4 MYD88 CD79B CD79A PMC6595388__F7 Signaling pathway RIPK1 TRADD ECSIT TRAF2 FADD BAX PMC3992846__F2 Production of biosynthetic precursors during glycolytic metabolism and their putative regulation during Xenopus tail appendage regeneration SLC2A3 HEL-S-162eP PMC4298731__F6 Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma PLCB3 CREB3L2 FZD3 BRAF GSK3B NRAS ASIP DCT TYRP1 KITLG FZD10 KIT ADCY8 DVL1 CALML6 PLCB2 EDNRB EP300 MAP2K1 ADCY5 GNAO1 MC1R GNAS CAMK2A EPHB2 PMC6028640__F1 Schematic overview of the pathway linking IMMP2L to senescence IMMP2L SCCA2 GPD2 PMC7292335__F1 Cbl-B in T-cell activation IL2 CTLA4 PMC4411085__F7 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis CHMP2B VCP FUS PMC7937869__F7 Coronavirus N protein inhibiting IFNB production TBK1 TRAF3 IRF3 TRIM25 PMC2292467__F6 DNA replication and damage checkpoint regulation MRC1 PCNA CDC45 PMC4411085__F5 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis VAPB UBQLN2 FIG4 CHMP2B VCP PMC11053446__F6 KEGG pathway analysis for DE mRNAs from cTECs infected with IBV DMV/1639 or IBV Mass41 CD14 TLR5 CTSK TLR9 STAT2 IRF7 TRAF6 IRF3 MYD88 TNF TLR3 TLR4 CTRL LBP CD40 TYK2 CD80 FADD TIRAP PMC9120667__F1 Metabolism and Endocrine Disorders: What Wnt Wrong? PRMT1 APC LRP5 LRP6 PORCN DKK1 WLS PMC8224327__F2 Anti-Angiogenic Property of Free Human Oligosaccharides EGF VEGFC DLL4 EGFR VEGFA NOTCH1 PMC4258562__F1 Schematic presentation of the pathways involved in the inflammatory response during acute pancreatitis IL16 TLR4 MYD88 PMC1287678__F9 Putative signaling pathway of the evolutionarily conserved Toll/NFKB pathway utilizing the E LBP TRAF6 IRAK4 ECSIT PMC5429546__F4 KEGG analysis of upregulated and downregulated promoter DMGs showing involvement in a metabolic pathway OLAH MTAP HEL-S-278 DBH RDH12 PRODH ITPKA ALG10 TYMP CHSY1 PMC7004536__F3 Alterations in the oncogenic pathways in 88 NSCLC cell lines other than the CUL3‐KEAP1‐NRF2 system PIK3R1 RIT1 RBM10 BRAF ALK EGFR NRAS ARID2 PTEN RB1 MTOR CDKN2A CCNE1 NF1 PI3 SMARCA4 U2AF1 ATM MDM2 CCND1 CDK4 ROS1 HRAS ARID1A TSC2 ARID1B RET TSC1 ERBB2 STK11 SETD2 PMC7403894__F3 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies NLRP3 TLR8 TLR7 TLR4 IRAK1 GSK3B TRAF3 MYD88 TLR1 ACE2 HSF1 IL1B PMC3547105__F1 The autotaxin-LPA-LPA1pathway PC LPA GAST PMC3782523__F1 Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses CD80 PMC9260869__F6 Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells TRADD RP1 TNF TRAF2 PMC7403894__F1 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies NLRP3 TLR4 GSK3B TLR1 HSF1 SIRT1 PMC3102606__F4 Pathway context for RME modules found in glioblastoma NF1 EP300 ERBB2 EGFR MDM2 PTEN CDKN2A SERPINA3 MKI67 TARP PMC2991311__F4 Systems Biology Approach Uncovers Cellular Strategies Used by Methylobacterium extorquens AM1 During the Switch from Multi- to Single-Carbon Growth CS MICB ADA WAS CAD CIT RPE HPR MAL PMC7014913__F2 Pathogenic alpha-synuclein transmission VPS35 SNCA LRRK2 PMC6113245__F1 Biosynthesis pathway of HBGAs hCG_1998026 FUT3 PMC2800957__F1 Targets for lithium’s neuroprotective effects MARCKS BAD BDNF PMC3492042__F8 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains CDK2 CSK RAD21 CDK7 PCNA ORC2 SKP2 MYT1 PMC11599740__F2 Activating insulin growth factors and energy deprivation triggers the HIF signaling pathway NF1 TSC2 TSC1 OGT GRB2 VHL RHO IRS1 STRADA RHEB PMC3492042__F5 MicroRNA targetome suggests aberrant upregulation of T cell receptor signaling pathway molecules in ATL cells ITK FYN DAO LCK GRB2 LAT CBL PMC8932107__F4 BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea GRB2 SHE BDNF PMC6862444__F2 GBM induction of PD-L1 secretion STAT1 VGF EGFR TRAF6 IFNGR2 PTEN MYD88 MTOR IFNGR1 PMC4419223__F3 Green tea modulates the various cell signalling pathways in cancer PTEN TNF BAX PMC6880928__F1 Splicing the innate immune signalling in leukaemia U2AF1 IRAK4 MYD88 PMC4419223__F2 Role of green tea in cancer prevention through the modulation of genes involved in initiations, promotion, and progression of cancer COX2 BCL2 PTEN BAX PMC3492042__F3 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains WEE1 ATR MYT1 PMC10573510__F6 Asthma pathway EPO MBP APC CD40 TNF PMC5964147__F7 HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer MMP2 TIMP3 MMP9 CCND1 CCNE1 HMGA1 PMC3196058__F2 Dynamic Role of Beta-Catenin in Synaptic Plasticity APC GSK3B CAD PMC6938674__F8 Targeting CDK7 for treating Yap/Taz-driven cancer POLL CDK7 POLI PMC3317271__F1 Simplified scheme of cell death and survival pathways involved in ALF TNF TRAF2 FADD ROS1 BAX PMC8444356__F2 Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target EGF MMP12 EGFR PARP1 CDH2 MTOR FGL1 PMC4864964__F1 Processes involved in generation of the T cell-inflamed tumor microenvironment phenotype CXCL10 CXCL9 CD80 PMC11918971__F7 Aerobic exercise (AE) stimulates the synthesis of anti-inflammatory “muscle factors” such as IL-6, IL-10, and IL-1ra through skeletal muscle contraction while reducing the activity of proinflammatory factors such as TNFA IGF1 CRH TNF BDNF PMC4864964__F2 How tumor-intrinsic Beta-catenin signaling mediates exclusion of T cells from the tumor microenvironment ATF3 CCL4 CD80 PMC8112849__F3 Melanogenesis signalling pathways MC1R PMC3991209__F1 Diagram showing activation of Notch signalling NOTCH2 NOTCH4 HEY2 NOTCH1 FURIN NOTCH3 HES1 PMC8081528__F9 The mechanism of Txnip-mediated cone rescue PARP1 TXNIP HEL-S-281 PMC8163614__F1 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease MFN1 MFN2 PMC8082854__F2 Metabolic adaptation mechanism of metastatic organotropism HEL-S-2a STAT1 AKR1B10 PC ASNS PRODH GATA6 TNF MTOR HEL-S-104 HEL-S-29 SDHB PMC8163614__F2 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease HDAC8 WNK4 PMC5752449__F6 Proteasome and ErbB signaling pathway BAD POMP MYC RPN2 MTOR CRK CBL IFNG BTC GRB2 ARC RP2 JUN PMC7005787__F6 UPR activation and patient outcome in cancer ATF4 EIF2A XBP1 PMC6275018__F3 Representative model of leptin-induced EMT signaling GRB2 STAT3 PMC8836072__F3 Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma BAD BCL2A1 APAF1 BIK BMF FADD HRK PMC5752449__F4 Shared and specific mechanism of four autoimmune diseases CTSK TRAF3 TRAF6 IRF3 RAC1 MYD88 TLR3 CPO PDC CD40 LPP FADD TIRAP PMC5752449__F5 The shared and specific mechanism of four autoimmune diseases BAD DAO EGFR INS HBEGF FSHB RHEB INSR TSC2 TSC1 MMP2 GAB2 GRB2 CAD CDC42 PMC7215987__F1 Phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway TSC2 RICTOR TSC1 PTEN EIF4E MTOR DEPTOR IRS1 RHEB PMC7215987__F2 Main components and crosstalk between the Ras-Raf-mitogen-activated protein kinase-Ras- extracellular signal-regulated kinase (Ras-Raf-MEK-ERK) pathway, the spleen tyrosine kinase (SYK) pathway and the PI3K-Akt-mTOR pathway TSC2 BAD TSC1 SRC SYK PTEN EIF4E DEPTOR IRS1 RHEB PMC7449758__F7 Proposed action model for the PI3K/AKT/FoxO3a pathway via ROS regulating DNA damage in the lung, liver, and kidney induced by Nano-TiO2 intratracheal administration GADD45A ROS1 PMC3674381__F7 Model of XIAP as a switch between type I and type II signaling BAX PMC7468012__F1 Embryonic MTHFR contributes to blastocyst development MTR SHMT1 HEL-S-51e PMC8077906__F1 Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review LCK ZAP70 MTOR PMC3531868__F1 Receptors for IL4 and IL13 are comprised of four different subunits, IL4RA (green), gamma chain (Gc; purple), IL13RA1 (red), and IL13RA2 (yellow) IL13RA1 IL13 IL4 PMC3512134__F6 Overall organization of mitotic exit control CDC20 APC PMC7855837__F1 Elesclomol: a bis(thiohydrazide) amide compound that binds copper in a 1:1 ratio FDX1 DBH HEL-S-44 PMC4316689__F2 Activation of RAS–MAPK pathway induces expression of numerous genes, some of which can be targeted WDR5 EBNA1BP2 GOLT1A HCTP4 AURKA TF CENPA AURKB KIF11 PMC2838081__F10 Molecular pathways regulated by C/EBPB during E-induced proliferation of uterine epithelial cells ATM CDK2 ATR RAD18 E2F3 PMC8229353__F1 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification APC GSK3B LRP5 CCND1 LRP6 HEL-S-133P STAT3 PMC8229353__F2 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification PIN1 APC HEL-S-133P PMC4838196__F3 Phosphoproteome analysis links protein phosphorylation to cellular remodeling and metabolic adaptation during Magnaporthe oryzae appressorium development GDE1 ATG12 CAP1 ATG3 PGM2 PSD2 SNX4 GSG1 ATG10 SLA2 DKFZp686F0183 PMC7273358__F6 Metabolic rewiring of the hypertensive kidney GLB1 MAPK8 BCAT2 MAPK3 ALB MYC MAPK14 AKR1C1 HIF1A HSD17B10 TRPV1 IFNG ACOX1 NLRP3 ACADS NPY SCD HEL-S-11 LPL PTK2B APOE SNCA FOS VEGFA DLD TNF HMGCR ACAT2 APOB LEP IGF1 CDKN1A ABAT VCAM1 NR1C2 BCL2 CRTC1 EHHADH TGFB1 KRT12 CD36 FGF21 HGF EXOSC8 EGFR TPM3 INS RHO MTOR GCG RPTOR FOXP3 PRNP RNASE1 TLR4 ACAT1 IVD CRP LDLR IL17A APP IL2 KNG1 IL4 JUN FASN IL10 FOXO3A MMP9 PTGS2 NFE2L2 PTH DBT NR1C1 PRL CASP3 CCK CNBP ACSF3 PPARG ACD ECHS1 ACADM CYCS PMC4167267__F7 Observed tumor patterns FBN2 BRAF KEAP1 ARHGAP32 ETV6 GSK3B PTEN RB1 MTOR RANBP2 NBPF10 NF1 SYNE1 SMARCA4 NKX3-1 ERG CDKN1B APC HRAS FOXO1 MAP2K1 BRCA2 POTEF STK11 SETD2 TERT PMC8756109__F7 Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11 EGFR RILP PMC2195768__F6 Proposed signaling pathway of the purinergic receptor: regulation of cardiac autonomic activity FYN TEC PMC6419954__F6 G-protein mediated effects on smooth muscle tone regulation GFAP UNK CRAT RHO CYFIP1 PKN1 PMC3953345__F2 Schematic presentation of the molecular mechanisms of myogenic differentiation MYF5 PAX3 MEOX1 MYOG PMC5649202__F2 Gene regulatory network (GRN) inferred for members from the NFKB pathway PRKCI CHUK ATM BASH SYK CARD10 PMC9678096__F7 Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway SOX2 SIRT1 PMC5649202__F4 Gene regulatory network (GRN) inferred for members from the TP53 pathway GADD45G SFN CD82 EI24 DDB2 CCND2 CCNE1 TSC2 GADD45B RRM2B IGF1 PERP ATM APAF1 PPM1D CCNB2 CCNB1 MDM2 TP73 CDC2 SESN1 ATR CYCS BAX PMC4633791__F1 Activation of effector and regulatory T cells by antigen presenting cells APC CD40 FOXP3 PMC4633791__F3 Induction of cell lines of spy cells into functionally distinct Treg lines IL5RA APC IRF4 FOXP3 PMC4633791__F4 Newly recruited CD4+ T-cell soldiers induced to be spies APC FOXP3 PMC4633791__F5 Activated and aggressive CD4+T cell soldiers convert to spies FOXP3 PMC3974997__F2 Interference with the host NFKB signaling pathways by STPKs of pathogenic bacteria: LegK1, OspG, and NleH1 RELB RPS3 CRKL PMC4489880__F5 When pathways collide: collaboration and connivance among signaling proteins in development NF2 EGFR SHH LATS1 LATS2 FRMD6 PMC5723694__F7 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion STAT1 IFNG STAT3 PMC4489880__F4 When pathways collide: collaboration and connivance among signaling proteins in development NF2 LATS1 LATS2 FAT4 PMC4252843__F5 PROTEASE MEDIATED HUMAN SMOOTH MUSCLE CELL PROLIFERATION BY UROKINASE REQUIRES EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION BY TRIPLE MEMBRANE SIGNALING ADAM12 EGFR HBEGF ADAM10 PMC2202913__F1 Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis POMC AgRP ARC PMC4489880__F1 When pathways collide: collaboration and connivance among signaling proteins in development APC LRP5 LRP6 PMC5723694__F3 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion IRF9 PIAS1 TNF IFI35 IRF-1 SOCS1 IFNG IFIT1 PMC4489880__F2 When pathways collide: collaboration and connivance among signaling proteins in development SRC ARHA RYK PMC6302376__F5 Regulatory relationships between genes in a signal pathway regulating the TP53 gene ATM MDM2 PMC5667558__F1 microRNAs and lipid metabolism ATP8B1 ATG12 LIPA ABCG1 PRKAA1 ABCA1 ALDH1A2 DKFZp686F0183 PMC7069501__F3 Therapeutic targeting of trained immunity NLRP3 TNF MTOR IL1B NOD2 CD36 PMC8138124__F1 New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response PALB2 BLM NONO WRAP53 SETMAR MDC1 SFPQ PARP1 FUS HDAC1 BRCA1 PRPF19 RNF168 CIRBP RNF8 ATM BRCA2 RBM14 RAD51 RBMX GEMIN2 DNA2 PMC9694773__F1 The Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment UROD UROS FH CPO PMC8123490__F4 Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC TH CCR5 LOXL2 CCR2 TG NR1C1 PMC7415776__F1 Metabolic rewiring of cyanobacterial central metabolism with a synthetic acetate‐acetyl‐CoA/malonyl‐CoA (AAM) bypass for improved photosynthetic production of acetone from CO2 AIDA GIP MAL PMC2836122__F2 Cytokine signaling through the JAK/STAT pathway STAT1 SOCS3 LIF IFNGR2 IFNAR2 IFNAR1 IFNGR1 SOCS1 STAT3 PMC9227908__F4 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches ISCU MTOR HK2 FASN PMC9227908__F1 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches TIGAR MYC RPIA HEL-S-133P PMC6485631__F1 CD69: from activation marker to metabolic gatekeeper JAK3 CD69 PMC9099129__F3 Natural killer cells in liver transplantation: Can we harness the power of the immune checkpoint to promote tolerance? LCK ZAP70 PMC6643109__F3 In T2 DM rats, where the Hepatic Glucokinase (HGK) is lower, the level of lncRNA NONRATT021972 is increased GSK3B HEL-S-70p PMC3254042__F7 Signaling pathways involved in synaptic plasticity and neuroglia functions with associated molecules and cellular tasks (analysis based on Ingenuity IPA software) EGF BRAF MDM2 GRB2 PTEN MTOR PMC5070717__F1 GSK3B in TLR4 responses TBK1 TLR4 GSK3B TRAF3 TRAF6 IRF3 MYD88 MAP3K7IP1 TIRAP PMC5022960__F4 Regulating signal pathway related to gastric lipase (LIPF) and diacylglycerol kinase A (DGKA) in gastric cancer (GC) LIPF NPAS2 HDAC1 CEBPB MYOD1 DGKA PMC5070717__F2 GSK3B in TLR3 signaling TBK1 GSK3B TRAF3 TRAF6 IRF3 MAP3K7IP1 TLR3 PMC4575837__F2 Dietary restriction, mitochondrial function and aging: from yeast to humans FOXO3A EIF4E TFAM SIRT3 PMC7877093__F11 Five genes are indicated in red on the AGE–RAGE signaling pathway map after PGQYD treatment (red) EGR1 MMP2 CDK4 IL6 TG TF SELE BAX PMC9097084__F9 Transcriptional Profiling of Resistant and Susceptible Cultivars of Grapevine (Vitis L.) Reveals Hypersensitive Responses to Plasmopara viticola MYB STS ERF PMC3531794__F1 Impact of IL-27 on lymphocyte signaling pathways STAT1 CXCR3 AHR EBI3 TYK2 JAK1 GATA3 STAT3 PMC6835611__F7 Inflammatory signaling pathway and the resulting downstream responses VCAM1 IL13 MMP9 PMC7418786__F3 Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication OXSR1 CDC42BPB CLTA EGFR RPS6KA4 MAPK14 SIK3 PAG1 STAMBP NCK1 PRKCA ITSN2 EPN1 PTPN1 HGS BIN1 SRC EPHX2 EPS15L1 ITSN1 ARHGEF7 MAP2K2 PRKD2 HDAC1 CBL WASL AAK1 CTRL CTNND1 SOS1 PXN PACSIN3 AGFG1 STAT3 PMC4314215__F4 MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy HMGA2 TNC ZEB2 MYC ARHA RDX SOX4 PMC5233753__F1 Schematized general estrogen signaling pathway DKK1 MTOR PMC4646278__F8 Overview of the role of pioglitazone activated PPARG and ROCK inhibition on survival of dissociated single hPSCs GSK3B ARHA PMC6766413__F4 μOR regulation of CXCR4 working modelMorphine or other μ-opioids binding to μORs on cortical neurons activates a GAi-protein pathway that leads to de-acidification of endolysosomes, and efflux of endolysosomal iron to the cytoplasm PAK1 LIMK1 CXCR4 RAC1 CXCL12 PMC9613808__F2 Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics IKBKE TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 IFNAR1 TLR3 NLRP3 BTK TLR7 TLR4 ACE2 TMPRSS2 MAVS PMC6562674__F1 Hedgehog signaling pathway SUFU PTCH1 GLI3 SMO PMC7057977__F5 COAD “cyan” module APOL6 subnetwork HLA-E CMPK2 RNF213 EIF2AK2 APOL1 SP100 USP18 BATF STAT1 OAS3 LAP3 FAT10 PSMB9 IRF-1 CXCL11 IRF7 CXCL10 HLA-B HLA-C HLA-F HLA-A APOL2 EPSTI1 IFIH1 UBE2L6 IFIT1 IFIT3 PML IFIT2 NUB1 HERC6 BATF2 ETV7 CX3CL1 TRIM21 TYMP MX2 MX1 DTX3L ISG15 SP110 GBP1 OAS2 XAF1 TAP2 GBP2 PSMB8 LAMP3 BST2 IDO1 APOL6 IL15RA IFI35 GBP4 PSMB10 PSME2 PMC7540116__F1 Metformin inhibits cancer invasion and migration via AMPK signaling pathway TSC2 TSC1 IGF1R IGF1 CCND1 DEPTOR PMC7540116__F2 Metformin inhibits cancer invasion and migration by blocking EMT signaling pathway SMAD2 ZEB2 SMAD4 MTOR STAT3 PMC7540116__F3 Metformin inhibiting cancer invasion and migration HMGA2 TSC2 COX2 SMAD2 MYC SMAD4 MTOR STAT3 PMC4659166__F7 Network of interactions between GWAS candidate genes using ingenuity pathway analysis (IPA) LRCH2 PLEKHG1 SIPA1L2 KIAA1549 LATS1 LATS2 RSU1 NME7 SEC16A CEP192 CGN OFD1 THOC2 DOCK7 PMC5757216__F1 Circadian clocks: from stem cells to tissue homeostasis and regeneration CRY1 PERP FBXL3 CRY2 DBP TEF RORB PER2 PER3 HLF PMC3110863__F4 Regulation of MeCP2 expression by Bdnf GRB2 BDNF PMC3927937__F2 Mixed-lineage leukemia APC FLT3 BRD4 PMC9178375__F2 Gut microbes and muscle function: can probiotics make our muscles stronger? ULK1 IGF1R IGF1 PYY IRS1 PMC9477829__F1 Exosome biosynthesis and uptake pathways CD63 RAB31 PMC8889587__F6 Aberrant protein S-nitrosylation in ER stress-mediated insulin resistance ATF4 EIF2A ADA PMC3744831__F2 DDR-adapted model in meiotic silencing SPO11 ATM TOPBP1 MDC1 ATR H2AX PMC5188458__F1 Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease PMC7569438__F10 Molecular mechanism by which Guttiferone K exerts anti-inflammatory effects in Mtb-infected macrophages NLRP3 COX2 TLR4 TRAF6 MYD88 MTOR PMC1874671__F2 Genomic organization of the CDKN2A locus and description of involvement of its transcripts (p16INK4a and p14ARF) in the Rb and p53 pathways MDM2 CDK4 CDKN2A CDK6 PMC2754694__F1 Transcriptional regulation of human CYP17 SRC SIN3A SP3 PMC6125039__F1 Human and yeast peroxisomal Beta-oxidation pathways GNPAT FAR1 AMACR PHYH BAAT ABCD2 ACOX1 PMC4584349__F1 Metabolites of the folate cycle, transsulfuration pathway, and methionine (Met)-homocysteine (Hcy) cycle CTH HEL-S-61p PC PMC11084589__F2 Inhibition of pathway activity induces microglial cell state transition TLR4 TRAF6 ARHA MYD88 PMC11084589__F3 Increased pathway activity induces a shift from a neurotoxic to a neuroprotective state in microglia TLR4 TRAF6 CA3 MYD88 PMC11084589__F4 Possible targeting pathway of ABA in PD TLR4 MYD88 CAMKK2 PMC11611323__F2 Metabolism of AdA DBP ELOVL5 LBP ADA PMC8084697__F1 Type I and III Interferons in COVID-19 TBK1 RSAD2 STAT2 IRF9 TRAF3 IRF3 MYD88 TLR3 STAT1 ISG15 TLR8 TLR7 TLR4 TYK2 JAK1 ACE2 MAVS PMC11611323__F3 Action of AdA in NAFLD GPX1 ADA CD36 PMC6857111__F5 Coexpression network was constructed by WGCNA TH DCUN1D1 MXD1 JMY RGPD6 DAP RGPD8 RGPD1 SFRS18 ZBED6 RANBP2 PPBP ITK USP34 ALDH7A1 BCLAF1 RRM2 ZFYVE16 NIPBL SNCA CIRSR BMPER SRM RAN SKP2 PMC11913683__F4 CAT has anti-osteoporotic effects through other pathways COX2 GPX4 RUNX2 GSK3B BCL2 CYP1A1 PKD1 SIRT1 IFNG STAT3 PMC7359092__F1 Recent discoveries on the protective role of IL-22 against tissue injury FGF21 CCND1 BCL2 MTOR REG3G STAT3 PMC9325512__F1 CMTM6 and CMTM7: New leads for PD‐L1 regulation in breast cancer cells undergoing EMT CD47 SNAI1 CCL20 PMC3612515__F3 Graphical representation of Ingenuity Pathway Analysis results showing considerable overlap of the significantpredictor genes in the significant biologic pathways E2F4 BRAF PPP3CA WNT7A TEAD4 CEBPB PANK1 SNX7 MTUS2 YWHAG DYRK1B APBB1IP NAMPT ANXA1 YAP1 FGF2 NR3C1 NOL3 FOXO1 CUL4A HSPG2 TYMS ARHGAP21 ITGAV HEL-S-93 PMC4263413__F1 Transcriptome Profiles of the Protoscoleces of Echinococcus granulosus Reveal that Excretory-Secretory Products Are Essential to Metabolic Adaptation HEL-S-87p HEL-S-162eP PMC11913683__F2 Mechanisms by which CAT promotes osteoblast differentiation RUNX2 BMP2 GSK3B SMAD4 S100A12 TNF MTOR SMAD9 COX2 IGF1 PTCH1 SHH PKD1 SMO SMAD1 SIRT1 DKFZp781O1323 PMC11913683__F3 CAT inhibition of osteoclast differentiation CTSK NFATC1 SIRT6 OSCAR PTEN BAX PMC3612515__F1 Graphical representation of Ingenuity Pathway Analysis results showing significant predictors genes in ‘Gene Expression, Cell Cycle, Cancer’ pathway PPP3CA FKBP3 PANK1 ARL6IP1 PRMT1 ING5 MAPK4 CAMLG CPOX PARP2 CKAP2 RAD51 SEMA3C TP53AIP1 UNC5B PYHIN1 TRIM24 PMC8495591__F4 Blood glucose control contributes to protein stability of Ski-related novel protein N in a rat model of diabetes SMAD2 SMURF2 SMAD4 PMC3612515__F2 Graphical representation of Ingenuity Pathway Analysis results showing significant predictor genes in ‘InflammatoryResponse, Cell Death, Infection Mechanism’ pathway DCLRE1A MAN2A1 BAG6 FKBP3 RBX1 FBXW7 ARL6IP1 ING5 MED13L TGIF1 SEMA3C TP53AIP1 UNC5B PYHIN1 TRIM24 PPT1 CUL9 PMC4754720__F4 Metabolic regulation of mitochondrial transport and mitophagy ULK1 OGT FUNDC1 PGAM5 RHEB PMC4441389__F5 Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation GSK3B PTEN PMC7199713__F1 Herbal medicine on the intrinsic pathway of apoptosis APC LRP5 CCND1 LRP6 MTOR BAX PMC7199713__F2 Herbal medicine on the extrinsic pathway of apoptosis TRADD CDK2 MYD88 CDC2 FADD PMC4597337__F5 Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster NUMB HP HEL-S-28 NEDD4 PMC6450213__F5 Gene network on chemokine signaling pathway by KEGG analysis of module-related DEGs TIAM1 ITK PAK1 GRB2 SRC ARHA DOCK2 CRK ELMO1 PMC2740411__F8 Transcriptional regulation of cell cycle arrest gene p21 by ZBTB5 BCOR ZBTB5 SP1 PMC3977821__F6 Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa SDHC TNLG7C SDHA SDHB PMC6425710__F1 Pericytes contribute in homeostasis of the BBB through different mechanisms FGFR1 NGF DLL4 SMAD4 SRC NOX4 CDH2 HIF1A NOTCH3 PMC6425710__F2 Under pathologic circumstances, pericytes present stemness or trans-differentiation potential SOX2 MAP2 VCAM1 CD34 GFAP CD44 OLIG2 PMC3418731__F3 Signaling within the JAK-STAT pathway in bovine monocytes and M STAT1 IL1A IL16 STAT2 STAT4 GRB2 IL7R TYK2 JAK1 IFNAR1 IL2RB STAT3 PMC8297548__F2 TIRAP in the Mechanism of Inflammation HMGB1 BTK TLR4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR1 SOCS1 TIRAP PMC5820622__F2 Depiction of classical and nonclassical pathway to NF-kB (p65-p50 or RelBp52) translocation activation TRADD RELB TRAF3 TRAF6 IRAK4 MYD88 TLE4 GRB2 CD40 RAF1 CSA2 TRAF2 TIRAP PMC5472670__F1 The UPR signaling pathways ATF4 EIF2A XBP1 PMC5512418__F7 The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity LATS1 MYD88 LATS2 PMC1326326__F3 Proposed regulation of Cdc25A at the G1 and intra-S-phase checkpoints ATM CDK2 ATR PMC12105201__F8 SLC3A2 and SLC7A5 in the pathogenesis of OA SLC7A5 SLC3A2 MTOR PMC4259987__F2 Pathway analysis (STRING v9.05) of 39 proteins significantly dysregulated in the CSF of subjects with mild or moderate delirium relative to the mild AD control with no delirium FGA CHGB HRG CLEC3B IGFBP7 NRCAM APOD NCAM1 BCAN CLU HBA2 CSTA HP HEL-S-2 SCG3 APP HBB KLK6 APOH APOA2 APOE PMC3835199__F4 = Transporter, ◊ = Enzyme, ∇ = Kinase, ∆ = Phosphatase, = Transcription regulator, 〇 = Other, = Complex/group, = Peptidase DYNC1H1 THRAP3 PDE4B NRF1 GABPB2 CPAP HTT INTS7 CTXN1 GNB1 NDEL1 MTM1 PMC7078196__F6 Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation TSC2 IGF1R FURIN PMC8773838__F2 Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic Manifestations JAK3 JAK1 PMC3674867__F1 Plasminogen Activator Inhibitor-1: The Double Edged Sword in Apoptosis VTN BAX PMC8469138__F6 Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis NOTCH4 GNAI1 PRKCA APOB PLTP LCK STAT4 NOTCH1 GNAZ TYK2 JAK1 GAL APOE STAT3 PMC5467823__F6 Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer ADAMTS2 ADAMTS9 ADAMTS6 ADAMTS7 MMP21 ADAM18 ADAM11 PLN ECE2 BCL2A1 ADAM22 IL36G ROR2 ADAM21 ADAM20 ADAM30 PMC6952436__F1 Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment CDK2 LCK ZAP70 CD80 MTOR BATF PMC4594353__F1 Characteristics, regulators and effects of the epithelial-mesenchymal transition (EMT) CDH2 PMC3565216__F1 Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae CDS1 PC GPT2 INS PSD2 PMC7859098__F4 m6A modification in immune-related bone homeostasis PTH1R METTL3 VEGFA TRAF6 PTH PMC9021207__F2 Associated immune metabolism in the tumor microenvironment ARG1 PMC9563138__F2 Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs SQLE ACLY HMGCR FASN PMC4354380__F1 Polycomb and trithorax proteins regulate chromatin structure and gene expression PRC1 YY2 SIRT1 PMC5104533__F2 An Immunological Perspective on Neonatal Sepsis REST IL1B HEL-S-5 PMC8458393__F8 Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NFKB signaling pathway EPOR EPO TYRO3 MYD88 AXL PMC7426447__F2 Signal transduction of ginseng gintonin on the mammalian cell plasma membrane via LPA receptors, GPR40, and GPR55 GPR55 HEL-S-11 LPA BDNF PMC8486193__F4 Reactive oxygen species in cancer: Current findings and future directions APAF1 MTOR FADD BAX PMC7426447__F4 Signaling pathway for gintonin-mediated autophagic influx via LPA1 receptor HTT MTOR DKFZp686F0183 PMC5372489__F3A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus PRKCE SLC2A4 ACACA MAPK10 INS TNF CRK IRS1 INSR PIK3R2 CACNA1C PMC8922318__F5 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia CD14 NLK PAK1 MAX FOS PROC TRAF6 ECSIT CDC25B TNF TRAF2 MEF2C PMC8922318__F6 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia PLN TNC PI3 BCR CAV3 HRC MCU CAV2 TRDN PMC7991738__F1 Apoptosis regulation via Cl− channels in ESCC cell CLIC1 CLCN2 CNTRL SPAST CFTR ANO9 PMC9371493__F8 Active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking PIN1 MMP2 TNF TF SELE STAT3 PMC11729014__F13 Mechanism of action of NCOA4-mediated ferritinophagy-induced ferroptosis promoting endothelial injure CGAS VCAM1 APOE PMC3438185__F9 Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice FADD PMC10377123__F3 Pharmacological Potential of Betulin as a Multitarget Compound MAF GCLM AHR KEAP1 GCLC PMC11279831__F1 IL-36 signaling pathway AP1S3 IL36A SERPINA3 CCL3 CARD14 PMC8665538__F5 Comparative analysis of aneurysm subtypes associated genes based on protein–protein interaction network NLRP3 IL18 NLRP12 IL1B CASP5 CASP4 PMC4211323__F1 Possible roles of Hsp90 in AD TLR4 CDK5 PMC9530810__F5 Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary CD14 MOS FLNA SHE PFKL NAT2 MAX MAFK HPD HEL-S-11 F11 SPX HEL-S-133P PMC6306698__F6 Pharmacological regulation of pluripotency circuitry establishment during cellular reprogramming via the FEN-stimulated PPARA regulatory pathway NR5A2 NR1C1 RXRA PMC4549768__F1 DNA damage tolerance mechanisms RAD52 RAD51 POLN RMI1 PMC4549768__F2 Regulation of DNA damage tolerance by proliferating cell nuclear antigen modification POLN RAD18 PCNA PMC3843373__F4 The PI3K pathway is the evolutionary conserved signalling pathway to ensure that growth and development is synchronised to the appropriate metabolic conditions: energy and substrate requiring processes only proceed when a ‘fed state’ is indicated BAD PTEN MTOR PMC7682023__F5 Schematic depicting genes in the PLC signalling pathway PLCB2 PLCL2 PLCG2 PMC9026965__F1 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health MFN1 PINK1 CS NR1i1 RHOT1 IL6 MTOR SIRT1 FIS1 PMC9026965__F2 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health MFN1 NR1i1 BNIP3 PMC10385528__F3 Anticancer mode of action of melittin on the essential molecular targets in different carcinomas MMP2 CCND1 STAT3 BAX PMC3700115__F7 Known and novel roles of the p38-MK2/3 signaling pathway in cross-striated muscles EGR1 NRF1 SP1 TF PMC5026795__F1 Recognition of C. albicans by pattern recognition receptors TLR4 SYK IL4 TNF IL1B MAL PMC9421066__F2 Crosstalk between sonodynamic therapy and autophagy in cancer ULK1 ATG12 ATG3 NRBF2 ATG101 MTOR DKFZp686F0183 PMC2519092__F2 Cellular responses after six hours exposure to L HLA-A CDS1 TRH ARHA ACD HLA-C PMC9409683__F1 Regulatory Roles of Estrogens in Psoriasis ERG TF GPER PMC7035921__F3 miRNA regulation of miR-155 upon mycobacterial infection and dual role of miR-155 in the survival of mycobacteria COX2 TLR4 ATG3 FOXO3A MYD88 SOCS1 RHEB BACH1 GABARAP PMC8611092__F3 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression TCF12 MOV10 ZIC4 PMC8611092__F4 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression IGF1R PTEN MTOR ITGB1 PMC8611092__F2 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression RS1 BAD BCR PTEN MTOR PMC8611092__F5 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression RET NID1 PMC9672132__F1 Investigation of the physiological response of radiation-induced cystitis patients using hyperbaric oxygen IL10 IL1A NGF PTGS2 MAPK3 VEGFA PARP1 CCL5 IL6 TNF HMOX1 CNTF NTF3 TFF2 F2 CRH MAPK1 NOS2 IL4 CXCL12 BDNF JUN IL1B PMC3380339__F1 Cross-regulation between the IL-1B/IL-18 processing inflammasome and other inflammatory cytokines HMGB1 CARD9 RAB39A BCL10 CCL20 IRF3 AIM2 IL1B MAVS CCL3 PMC4395390__F3 Exploring Triacylglycerol Biosynthetic Pathway in Developing Seeds of Chia (Salvia hispanica L.): A Transcriptomic Approach FBL FARP1 FES FUS AGL FASN PMC10304248__F2 Mycobacterium tuberculosis and apoptosis modulation TRADD TNF FADD BAX PMC10304248__F3 Mycobacterium tuberculosis and the necrotic-like cell death modulation GPX4 TRADD IRAK1 RIPK3 TRAF6 MYD88 TNF NOD2 GSDMD HEL-S-69p ESX1 NLRP3 RIPK1 TRAF2 PTPA MLKL TAB3 PMC3313983__F5 Associations between HIV and Human Pathways Revealed by Protein-Protein Interactions and Correlated Gene Expression Profiles STAT1 EGF EGFR JAK1 TGFA STAT3 PMC7379134__F8 Schematic diagram showing the crosstalk of the ASK1-JNK1/2 pathway and ER stress during DICD BAD EIF2A BCL2 TRAF2 XBP1 PMC9554302__F2 Advances in RIPK1 kinase inhibitors TRADD CYLD TRAF2 FADD MLKL PMC7158602__F7 The functions of OMT on inhibiting NP cells inflammation HMGB1 IL16 TLR4 TRAF6 MYD88 PMC7641301__F7 Over-regulated pathway after 48 h Forskolin stimulation TH PLEC FOS EEF2 HEL113 LMNA JUN PMC8874497__F2 Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer ACO2 LDLR ACSS2 ABCA1 ACLY HMGCR PEMT CD36 PMC2998553__F3 Screen shot of the user interfaceofSimmune2.0 RET ZAP70 LAT PMC4133513__F1 Toll-like receptor signalling CD14 TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR4 LBP MAL PMC2912611__F8 From HLA-B27 to spondyloarthritis: a journey through the ER TH ERAP1 IL23R PMC8262388__F6 Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health FGF21 GDF15 ATF4 PMC2808058__F3 The effects of SOX4 and HOXC6 on Notch pathway activation and metastasis TNC DKK3 PSEN1 NOTCH1 BMP7 SFRP1 ADAM10 WIF1 SOX4 PMC2808058__F1 Schematic of the Notch pathway PSEN1 NOTCH1 BMP7 ADAM10 HES2 PMC2808058__F2 The effects of the SOX4 and HOXC6 transcriptional networks on PI3K-AKT pathway activation in prostate cancer FGFRL1 EGFR NOTCH1 FGFR2 SOX4 IGF2R PMC7916951__F1 Multiple intracellular pathways triggered by Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infection converge on expression of proinflammatory cytokines and type I Interferon (IFN) response genes CGAS TLR7 IRF7 TRAF3 TRAF6 IRF3 MYD88 IRF2 PMC1201514__F1 Regulation of the PIS1-encoded Phosphatidylinositol Synthase in Saccharomyces cerevisiae by Zinc CDS1 PSD2 PMC7858668__F2 Complement cascade and complement targeting therapies CD59 C4B_2 CD46 MASP1 DPP4 C6 C4A PMC3268389__F1 Pathways and compartmentation of FA supply for TAG synthesis in plants PC PMC3096054__F1 miRNA biogenesis pathways and regulatory networks AGO1 AGO2 AGO4 PMC7858668__F1 Complement in diabetic kidney disease HEL-S-62p CD59 CS PMC6856008__F6 MicroRNA Regulatory network with miRs from the anti-survival/EMT group BAMBI IGF1R IKBKG NFATC4 F2R PLCG2 PTEN CXXC4 TLR4 FGFR1 BCL10 WNT8B MDM2 IL7R GNG11 NTRK2 WNT7B ZNRF3 MAPK10 APC VEGFA FZD4 GNG12 NFATC2 PRKCB RELA TRAF1 LBP LYN TNR SYK MCL1 SOS1 HEL-S-93 LAMC1 TIRAP PMC5089367__F5 Targeted interactome of microRNAs (miRs) (miR-30c and miR-331-3p) GSK3B PMC7020042__F6 Schematic diagram showing D and DA on adipocyte differentiation through GSK-3B/Beta-catenin signaling in ASCs APC GSK3A CEBPA PMC5128196__F1 Huntington's disease pathway from KEGG database CASP3 HEL70 LIPI REST SIN3A SP1 BAX TAF4 PMC6341806__F2 Summarized molecular pathway of BDNF/TrkB's oncogenic role EGFR BDNF STAT3 PMC3443857__F1 Progesterone regulated paracrine signaling model depicted within the uterine compartments at the time of embryo implantation MUC1 IHH WNT4 BMP2 HAND2 PMC8469858__F1 Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer RAC1 AXL PMC7015852__F6 Water lily genome and the early evolution of flowering plants VIT NOTO PMC4076981__F8 Schematic drawing of the current model for the interrelationship between nutrient and light signaling in T PHIP GNB1 HEL-S-5 PMC7675406__F3 Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 CCR2 ICAM2 VWF CCL2 PMC8814673__F2 Advances in research on the effects of platelet activation in acute lung injury (Review) SRC SYK MAPK1 TNF PMC5173167__F1 Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy PC CXCL5 MMP9 MYC CCL2 CXCL12 ARG1 IL1B PMC4479818__F1 Folate metabolic pathway HEL-S-61p MTR DHFR MTRR TYMS MTHFD1 PMC5584302__F2 PD1 signal transduction pathways in T cells CDK2 ALB ZAP70 PTEN ITCH PMC8710012__F1 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis AREG MYC CCND1 LATS1 DKK1 LATS2 GATA3 PMC4939890__F2 Pathophysiological mechanisms involved in bicuspid aortic valve (BAV) WNT3A RUNX2 BMP2 LRP5 NOTCH1 ARHA SOX9 BMP4 PMC3705329__F1 SMAD/BMP pathway in hepatocytes SMAD4 HFE TF TFR2 PMC8710012__F4 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis HEL-S-62p LATS1 CDK9 LATS2 PMC5378358__F6 Transcriptome analysis of Corynebacterium glutamicum in the process of recombinant protein expression in bioreactors PC CIT MAL PMC7300268__F1 Regulation of YAP/TAZ AMOT BIRC5 VGLL4 MYC MARK4 ARHA LATS1 NLK TIAM1 NF2 CCND1 CDC2 AXL PMC8161467__F7 Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling DKFZp781B1423 MDM2 PMC7606690__F4 Nef-mediated activation of Itk requires Nef homodimers ITK HEL-S-11 LCK PMC8720622__F7 LncRNA LINC00460: Function and mechanism in human cancer KDM2A EZH2 CCNG2 PMC7352793__F6 ncRNAs involved in the IR-induced Wnt/Beta-catenin pathway TCEAL7 PMC2254178__F1 Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System APC GSK3B PMC8863344__F2 Reciprocal regulation of cellular mechanics and metabolism TRIM21 SRC RHO PMC3570203__F2 Genes highly expressed in TNBC compared to HR-positive, HER2-negative breast cancer TUBA4A MAP2 PLK1 FOXM1 TTK KIFC1 CENPF SERPINB5 TOP2A DEPDC1 KNTC2 CRABP1 MKI67 CENPA PTTG1 MYBL2 TACC3 CENPE HCTP4 CHEK1 AURKB HEL-S-162eP HEL-S-22 CDC20 MMP12 TYMS PMC3129465__F2 Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies CCL26 FLG WDR36 TSLP TGFB1 PMC3636031__F9 Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague TRAF6 FADD PMC9204334__F1 Molecular Role of IL-35 in Non-Small Cell Lung Cancer STAT1 EBI3 STAT3 FOXP3 PMC6468848__F2 The Notch signaling pathway SOX2 CCND1 CDK8 PMC6417835__F3 Architecture of the Fanconi anemia (FA) core complex, with FAAPs (Fanconi anemia–associated proteins) indicated by numbers REV1 FANCM UBE2T FANCL FANCA FANCB FANCE FANCG FANCF PMC6468848__F3 Functional effects of Notch-regulated miRNAs in glioblastoma NOTCH2 NOTCH1 DLL3 UVRAG PMC6417835__F4 Roles of FA proteins in replication stress BLM UBE2T MCM7 RMI2 MRE11A BRCA1 MCM3 MCM5 MCM6 MCM2 BRCA2 FANCM RAD51 FANCL ATR DNA2 PMC10840486__F9 Schematic illustration showing synergistic calcium supplementation and SIM delivery strategy for osteoporosis RUNX2 BMP2 F3 PMC6468848__F4 Other Notch-related tumorigenic aspects in the pathogenesis of Glioblastoma ID4 FOXG1 STC1 CHAC1 TRPM7 PMC8002742__F3 The NLRP3 inflammasome pathway NLRP3 IL18 IL1B PMC8185253__F11 Assessment of Significant Pathway Signaling and Prognostic Value of GNG11 in Ovarian Serous Cystadenocarcinoma NPAT CD47 CD44 VWF CHAD DMP1 CD36 PMC3624769__F1 Interferon (IFN)-Gamma-activated pronecrotic and prosurvival signaling pathways STAT1 JAK1 FADD MLKL PMC8536488__F1 Cancer and Covid-19: Collectively catastrophic TRADD TRAF2 FADD STAT3 PMC6471380__F1 Molecular mechanisms of insulin functions and associated modifications in the hypothalamus CCR5 GPR17 GPR78 PDE3B SOCS3 CCL5 PTEN RICTOR POMC TLR4 AgRP ATF4 STAT3 PMC6858945__F1 Outline of the molecular pharmacology and response determinants of clinical TOP1 inhibitors SLFN11 ATR CHEK1 MRE11A TDP1 PMC8002742__F1 The activation of the Toll-like receptor signaling pathway TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 TIRAP PMC3309175__F7 Mammalian target of rapamycin (mTOR) signaling pathway for the regulation of skeletal muscle protein synthesis in response to growth factors, nutrition, and mechanical stimuli ELF2 EEF2 RPS6 MTOR PMC8002742__F2 Activation of type I interferon production via endosomal Toll-like receptors and RNA sensor signaling pathway in Sjögren’s syndrome TBK1 TLR7 TLR9 IRF7 IRAK1 UNC93B1 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS PMC4970451__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue CXCL8 IL1B PMC6237962__F3 Results of significant canonical pathways associated with ion-transport and the molecules involved PLN ATR RYR2 PMC6237962__F4 RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization CREM SRC CFTR PMC8704918__F2 CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression MRC1 CCNC PMC8503187__F1 Biased Ghrelin Receptor Signaling and the Dopaminergic System as Potential Targets for Metabolic and Psychological Symptoms of Anorexia Nervosa POMC NPY AgRP MC4R ARC PMC2769253__F3 MicroRNAs in cancer E2F2 MYC E2F3 PMC3137003__F2 The insulin and leptin-melanocortin signaling pathway is responsible for maintaining energy and metabolic balance by controlling appetite POMC AgRP MC4R PMC2769253__F1 MicroRNAs in cancer DROSHA PMC8163825__F2 Key metabolic pathways in Hermodarchaeota genomes AGA VILL MAL PMC8997791__F2 Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases KEAP1 MTOR DKFZp686F0183 PMC3433932__F3 The scheme summarizes the stretch-induced pathway that allows ROS scavenging in response to mechanical stimuli EGR1 SIRT1 PMC6639758__F3 An example of autocrine and paracrine interactions between NPY neuron (blue) and POMC neuron (green) in the ARC and their downstream effector neuron (i.e., neuron in PVN; beige) POMC NPY AgRP MC3R PMC2818158__F1 Inflammation at a molecular level: a simplified scheme TLR4 IRF3 TNF TLR3 MAL PMC5314324__F5 Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity CS PTMA UBE2S PMC2315691__F1 Complement system and complement regulatory proteins (CRegs) CD59 CFB MASP1 CR1 PMC12217925__F8 CDH17-mediated regulation of LGR5 expression, Wnt signaling and drug resistance SLC38A5 CDX2 MYC ABCG2 GPR49 EPHB2 CDH17 PMC4253612__F3 Genes in cancer-related pathways NFKB2 APC MMP9 EGFR GSK3B MYC GRB2 SRC ATF5 RAF1 TNF HRAS PMC4881561__F4 Notch signaling pathway and the localization of NSD1, BAP1, PDE4DIP and ATP10B in mesothelial cells NOTCH2 ATP10B PDE4DIP PMC6142509__F1 Activation and regulation of the alternative complement pathway HEL-S-62p CFB CFD CFH CFI PMC5258846__F1 Microtubule motors drive Hedgehog signaling in primary cilia KIF7 SUFU GLI3 SMO PMC5155223__F6 Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma SRGAP2C ROBO1 SRGAP2 PMC1939900__F6 Different signaling pathway mediated by A3(IV)NC1 RELA EIF4E MTOR PMC4965087__F2 Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment BAD MYC GADD45A PTEN CCNG2 RFWD2 TSC2 CASP3 RRM2B CDR2 SIAH1 PERP CDK2 CCNG1 MDM2 CASP9 ATR PMC2582809__F1 Role of cytokines in DC and T-cell interactions APC IL23R FOXP3 PMC9709755__F3 Transcriptome profiling of colorectal tumors from patients with sepsis reveals an ethnic basis for viral infection risk and sepsis progression RPLP2 RPL7A ACTA2 MAPK3 GSK3B ITGB6 RHOV RPL9 MYH7 MTOR MAP2K6 PARVA RPS26 RPTOR RPS24 EIF3E RPL12 MYH4 RPL21 ATF4 RPL23 RPL26 HEL114 ITGB3 RPL13a ACTG2 HEL-S-28 RND2 RPL38 RPL6 RPS16 MYH6 CASP3 PPP2R2B ARHG CREBBP NFKB2 PPP2R5C PRKAG2 VEGFB PPP2R5D SHC1 CP PMC3109603__F7 Comparative pathway networks of cyclic genes in mouse, chicken and zebrafish DUSP4 TNFRSF19 NRARP DKK1 ID1 NKD1 HES1 HES5 DUSP14 DUSP2 AXIN2 SP5 DACT1 PMC12027552__F7 Correlation network diagram of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) in the plant hormone signal transduction pathway under the FR treatment BIN2 EBF2 TF PMC6540516__F8 Evolution of erlotinib resistance in CD166+ OSCs TWIST1 EGFR PMC3997714__F1 Autophagy is involved in the initiation of hepatocarcinoma (HCC) EIF2A MTOR PMC9019486__F3 miR-874: An Important Regulator in Human Diseases TFAP2B AQP1 YAP1 APC LATS1 CDK8 LATS2 AQP3 SUFU PTCH1 SMO CXCL12 HMGB2 STAT3 PMC4279367__F1 Under physiological conditions, ERK signaling is regulated by extracellular signals binding to receptor tyrosine kinases (RTKs) NF1 CDK4 PTEN RB1 MTOR PMC9692680__F5 Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of Aspalathus linearis for Type-2 Diabetes Care PRKCB EP300 RELA EGFR HK2 INSR PMC9644706__F3 FADD as a key molecular player in cancer progression BCL2 FADD PMC6281268__F9 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis CORT PC PMC6300493__F2 WW domain protein roles in genomic stability RNF20 ATM SMURF2 ATR BRCA1 WWOX ITCH PMC6281268__F6 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis WEE1 ATM GSK3B ATR MYT1 PMC6281268__F7 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis MCL1 CAD TNF DIABLO HTRA2 BIRC6 CYCS BAX PMC6281268__F8 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis LTA UST TNF PMC6300493__F7 E3 modulate breast cancer cell invasion and metastasis EGF SMURF2 CXCR4 EGFR USP9X WWP1 SMURF1 ITCH PMC6431671__F7 Integrative pathway enrichment analysis showing the interaction between predicted and experimental targets HRG ADCY1 EEF2 LSM6 VEGFA SMAD4 CREB1 ITIH4 ORM1 ITIH2 SERPINC1 APOB A2M HP SERPING1 SERPINA1 HEL-S-72p PMC6300493__F6 E3 ligases regulate breast cancer cell proliferation AMOT SMURF2 LRP5 LRP6 WWP1 WBP2 SMURF1 ITCH PMC6300493__F4 Inactivation of the Hippo pathway induces breast cancer metastasis ABL2 LLGL2 MARK4 ABI2 LATS1 SKI MOB1A NSUN6 PMC5519339__F2 CREB-induced IL-10 production is regulated by IFNG GSK3B SP1 PMC3365841__F16 GPCR-modulated channel activity in pituitary cells CRH ERG TRH NACA2 VIP GHRH PMC7399097__F3 Interleukin-17A signaling transduction pathway BAD DDX3X TRAF6 CAD TRAF2 IL17RC ARID5A TRAF4 TAB3 PMC4309263__F6 Schematic representation of the reciprocal auto-sustaining loop between Jagged1 ligand and Notch3 receptor in T-ALL NOTCH1 ADAM10 NOTCH3 ADAM17 PMC3365841__F11 Pituitary cells express GPCRs that engage the cAMP signaling pathway SST CRH VIP GHRH PMC2872116__F1 Analysis of a protein interaction network in the context of the T-cell pathway MAPK12 FOS LCK REL JUN PMC2872116__F2 Structuring protein interactions around familiar canonical pathways provides intuitive visualizations NPAT LCK REL RAN PMC11577955__F8 Mechanisms underlying the tryptophan metabolic pathway DDC DLD AFMID TDO2 PMC5841164__F1 PTEN signaling in Treg cells NRP1 APC PTEN FOXO1 FOXP3 PMC11411235__F4 Functions of tetraspanins in PC VEGFC MMP9 TSPAN7 TSPAN8 SRC TSPAN1 STAT3 TET2 PMC11411235__F5 Functions of tetraspanins in CRC TSPAN5 TSPAN12 TSPAN8 TSPAN1 TSPAN9 TSPAN6 PMC11411235__F2 Functions of tetraspanins in GC TSPAN5 MMP7 TSPAN31 EGFR TSPAN8 TSPAN1 TSPAN9 PMC11411235__F3 Functions of tetraspanins in liver cancer TSPAN5 TSPAN31 ADAM12 MMP9 GSK3B TSPAN7 TSPAN8 TSPAN1 CDK4 TSPAN15 PMC4667402__F2 Comprehensive illustration of transcription changes in skeletal muscle of red cusk-eel under handling stress using modified KEGG pathway maps using Pathvisio v3 TMOD1 HERC2 ATG12 TPM1 SMAD2 TPM3 RPN2 TNNT1 DES PRH2 ULK2 RPN1 DMD UBC HEL-S-108 HEL-S-273 HEL113 UVRAG UBE4B MYOD1 PMC3110626__F1 Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome PIK3CD PIK3R1 BAD PTEN MTOR PIK3R3 PIK3R4 MDM2 PIK3CA CCND1 RBL2 PIK3R2 TERT AKT3 PMC9136039__F6 Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer CXCR1 APC CXCL8 IL8RB CXCL3 PIGR TFF3 EECP GAST PMC10135467__F2 Illustration of the regulatory network of METTL3 in the nervous system SOX2 TRAF6 ARC EZH2 DLL3 NPAS4 FXR2 BDNF ERFL PRRC2A PMC8750188__F3 Identification of Let-7 miRNA Activity as a Prognostic Biomarker of SHH Medulloblastoma LIN28B LIN28A PMC8566343__F10 Comprehensive Proteome and Acetyl-Proteome Atlas Reveals Molecular Mechanisms Adapting to the Physiological Changes From Pre-laying to Peak-Laying Stage in Liver of Hens (Gallus gallus) KY HEL-S-11 F2 PPA2 ADA AADAT CROT CAD EHHADH PMC9582773__F2 Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease TLR7 TLR9 MPO KEAP1 CRP TNF TMPRSS2 PMC2933676__F3 The canonical Wnt signaling pathway TEF LRP5 NDP PMC6369205__F11 Regulatory role of GRK2 in TLRs-mediated signaling pathways for iNOS expression in microglial cells STAT1 TLR4 TLR9 ADRBK1 IRF-1 TLR3 STAT3 PMC9355054__F1 Systematic review: Molecular docking simulation of small molecules as anticancer non-small cell lung carcinoma drug candidates EGF EGFR GRB2 PTEN PMC3364993__F5 Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes EGF EGFR SRC PMC9323107__F2 Need for Individualized Risk Assessment in Cardiovascular Disease TFPI PLG PMC8469784__F8 Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview ASMT AANAT PMC5372366__F4 Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus SPARC PSAP TGFBI PMC9664769__F5 Disinfectant dodecyl dimethyl benzyl ammonium chloride (DDBAC) disrupts gut microbiota, phospholipids, and calcium signaling in honeybees (Apis mellifera) at an environmentally relevant level CAV3 BDNF DMD PMC9575643__F2 Cellular, molecular, metabolic and epigenetic approaches to studying trained immunity TLR4 TNF IL1B PMC6791490__F3 Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches TH AHR TSHR TRH TPO TRHR PMC4543340__F1 HGF/MET signaling pathway HGF GAB2 PMC8790411__F1 Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers POLE MDM2 CXCL9 TET1 PMC3791171__F4 Molecular pathogenesis and mechanisms of thyroid cancer BRAF TSHR TPO TG PMC3791171__F1 Molecular pathogenesis and mechanisms of thyroid cancer SLC5A8 FOXO3A TSHR TIMP3 VEGFA TPO HIF1A TGFB1 PMC3791171__F2 Molecular pathogenesis and mechanisms of thyroid cancer FOXO3A GSK3B PTEN MTOR PMC4658327__F1 Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation MUC1 GNE OGT GC EGFR NPL RENBP COCH PMC4252768__F2 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders ROR2 STAT3 PMC9706101__F2 Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors TSC2 FOXO3A NFAT5 TNF IL23R WNK4 SGK1 FOXO1 PMC4252768__F1 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders APC LRP5 LRP6 ROR2 RHO PMC3593299__F1 Ghrelin neuroprotective pathways in Parkinson’s disease PINK1 ULK1 GHSR LRRK2 MTOR TFAM UCP2 PMC3816228__F2 Receptors involved in allergen recognition and uptake by AECs TLR4 EGFR CCL20 SYK TSLP PMC5831949__F3 Key biological pathways with DNB genes in cytokine-cytokine receptor interaction and PPAR signaling pathway CCR2 EGF GHB2 CCL2 IL17RB OSMR UBC KDR AMH SI CNTFR GHR LEPR CCL25 SP7 INHBC PIGF HEL-S-28 LIF TNLG2B TNF TNLG7C TSLP EDAR LEP IL7 LTA PRLR INHA CCL23 OSM MPL PMC9126461__F1 Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features RASSF1 BRAF GRB2 RAC1 PMC5796257__F1 Deregulated frizzled (FZD) in Wnt/Beta-catenin signaling SOX9 ELL PMC7981598__F5 Description of 3 overlapping-pathways for complement activation: The complement: opsonin C3b, anaphylatoxins C3a and C5a (complement peptides), and membrane-attack complex (MAC, C5b-9), produced by all three pathways HEL-S-62p PMC8543968__F6 Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium EGFR CDK4 MCU STIM1 PMC6188668__F7 Arid5a in the IL-17R signaling pathway NFKBIZ TRAF2 IL17RC ARID5A CEBPB PMC9470149__F2 The CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications CCR2 JAK3 CCL2 MTOR PMC9010225__F2 Emerging role of PARP-1 and PARthanatos in ischemic stroke TRPM2 PARG PMC2947178__F8 Model for the Coordinated Action of the Mating Types to Regulate Different Stages of Pathogenic Development of U CLP1 PRF1 PMC10989365__F6 CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway PTEN CALD1 PMC8789681__F1 Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms FLNA SMAD2 TGFBR1 TGFBR2 RHO TPT1 PMC5927358__F1 Canonical Wnt signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 PMC7981598__F2 Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs ATR ACE2 PMC5927358__F3 Wnt/TOR and Wnt/STOP signaling pathways TSC2 APC GSK3B LRP5 LRP6 PMC5671492__F7 Biphasic concentration-dependent regulation of Cav-1 gene expression and GSK-3B activity by fluoxetine in astrocytes EGF EGFR GSK3B SRC PMC5831797__F2 Schematic depiction of the cross-talk between Hh signaling and DYRK kinases PTCH1 GLI3 SMO DYRK2 DYRK1B DYRK1A MAL PMC6771624__F5 KEGG pathways for TCA cycle and retinol metabolism in the T 6 vs LRAT UGT1A9 FH ACO2 RETSAT DHRS4 IDH3B CYP1A2 SDHD HEL-S-32 PMC7397755__F1 Lineage plasticity in cancer: a shared pathway of therapeutic resistance SOX2 NKX2-1 EGFR MYC EZH2 RB1 PMC8979719__F7 Comparison of Three Species of Rhubarb in Inhibiting Vascular Endothelial Injury via Regulation of PI3K/AKT/NFKB Signaling Pathway MPO EGFR ALB ALOX12 MTOR POR ADAM17 MMP2 MDM2 SRC NOS2 KIT PTGS2 FGF2 MMP9 VEGFA MMP15 IL6 TNF AURKA ERBB2 PIK3CA BCL2 SELP PPARG TERT STAT3 PMC7476343__F1 Representation of the reciprocal links between cancer and thrombosis PC APC VWF TF PMC6144451__F7 The effects of CLN3, flupirtine, retigabine, and benzyl (compound 5) or allyl (compound 6) carbamate derivatives on ceramide synthesis and intrinsic/extrinsic apoptotic pathways SMPD1 CLN3 DEGS2 FADD CERS2 CERS6 BAX PMC4744706__F2 Key players of the mTOR complex1 cascade in LR asymmetry Cartoon depicting a simplified model of the TORC1‐dependent signalling pathway and its physiological outcome TSC2 ULK1 TSC1 GSK3B ATG14 PMC9317563__F1 Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms PIG59 MHC2TA HES6 TLR9 RUNX2 ETV6 NRAS MYC TRAF3 TRAF6 MYD88 RB1 MTOR NLRP3 BTK TLR7 TLR4 IKZF1 ATM BASH ZEB2 SRC EZH2 AXL AIM2 ICOS POLI CD47 IRF7 IRF8 IRF3 CTLA4 TIGIT TNF NFATC3 TLR3 TET2 SIRPA CD27 SPIB ZRSR2 BCL2 CD40 SYK CD80 TCF4 PMC5795054__F1 Scheme of the biosynthetic pathway downstream to phenylalanine FH PAH PMC5336482__F2 Involvement of GSK3 in TLR4 signaling pathways.Activation of TLR4 by LPS or alarmins (called ligand in the figure) involves dimers of TLR4 binding to CD14 and MD-2 TBK1 CD14 TLR4 TRAF3 TRAF6 IRF3 MYD88 PMC3407815__F1 The interleukin (IL)-12/IL-23/interferon (IFN)G pathway and its role in mycobacterial disease control STAT1 IRF8 CD40 JAK1 PMC9179367__F1 Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares NAPRT NAMPT SLC5A8 PMC8067156__F2 Pathophysiology of Ulcerative Colitis CXCL1 CXCL10 CXCL8 CXCL3 IRF4 GATA3 FOXP3 PMC8502484__F1 Parallels Between the Antiviral State and the Irradiated State CGAS TLR9 STAT2 IRF7 IRF9 TRAF6 IRF3 MYD88 TLR3 STAT1 TLR8 TLR7 AIM2 MAVS PMC9467317__F4 TI2-induced subnetwork TRADD PROC DES TNF CASP3 CBX2 CYLD APP CASP9 CSA2 FADD MLKL CP BAX PMC9065611__F5 Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto ALAS1 FECH UROD UROS HMBS CPOX ALAS2 PMC8434535__F11 Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish NRF1 GCLC EIF2AK2 TXN NQO1 BACH1 CRYZ SIRT3 HEL-S-2a MAFK EIF2AK4 HEL-S-44 HEL-75 CCS PMC11705637__F4 Main pathways involved in INPP5E activation SUFU AURKA INPP5E PMC8160090__F1 JAK-STAT in Early Hematopoiesis and Leukemia STAT1 CLPS TPO LEPR TYK2 JAK3 JAK1 CXCL12 STAT3 PMC9467317__F1 TNFR1 signal transduction pathway TRADD CYLD TNF TRAF2 FADD MLKL PMC8979819__F8 Schematic summarizing the effects of Gab2 on RTK expression and signaling in Flt3-ITD positive AML RET GAB2 AXL GFRA2 PMC1361319__F1 Scheme of branch pathways of phenylpropanoid metabolism in plants leading to the synthesis of anthocyanins, flavonols, PAs, and lignin HEL-S-62p CAD PMC4618268__F1 Everolimus Combined With Gefitinib in Patients with Metastatic Castration-Resistant Prostate Cancer: Phase I/II Results and Signaling Pathway Implications IGF1R EGFR FKBP5 PMC11653102__F8 AD-like neuropsychiatric dysfunction in a mice model induced by the combination of high-fat diet and intraperitoneal injection of streptozotocin TREM1 TNF IRS1 PMC8226009__F4 N6-Methyladenosine RNA Methylation Regulator-Related Alternative Splicing (AS) Gene Signature Predicts Non–Small Cell Lung Cancer Prognosis PML TH HMGCL CRAT ERF POLL MORF4L2 NLK PTS FYN CFH APP NEK11 PMC2215060__F1A WE GATHER TOGETHER: INSULATORS AND GENOME ORGANIZATION IGF2 CTCF PMC8084285__F2 Promising role of defensins peptides as therapeutics to combat against viral infection INA SHE ACE2 PMC5278199__F1 Human EGF signaling pathway (reprinted from Biocarta ) EGF SOST GRB2 SHE RAF1 STAT3 PMC5993136__F1 Regulation of lipid metabolism in cancer cells DGAT2 ACSS2 MTOR TG HMGCR DGAT1 ACAT1 LDLR ABCA1 ACLY SLC25A1 FASN CD36 PMC3786223__F2 The potential role of miRNAs in the attenuated myogenic process in the elderly IGF1 SMAD2 CDC34 PMC11885449__F10 Mito-nuclear carbon metabolism in Toxoplasma HEL-S-26 FH APC CIT MAL PMC4177046__F1 Aberrant Regulation and Function of MicroRNAs in Cancer AGO2 DGCR8 DROSHA PMC4631599__F9 Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells PI3 TLR4 PMC4057758__F6 Graphical representation of two of the top score networks identified by Ingenuity Pathway Analysis (IPA) MAX SUV39H1 ATM DHFR MDM2 SMAD4 NRG1 SIN3A ATR BRCA1 PCNA PMC3696504__F1 Relationship between metabolism and the autophagy machinery during the innate immune response IL10 IL18 ATG12 ATG3 IL13 IL6 IL4 UVRAG ATG10 HIF1A DKFZp686F0183 IFNG PMC2196458__F7 Fas-signaling pathways in relation to the cytoskeletal networks, the Golgi-sorting compartment, and the surface membrane EGF GC EGFR FADD PMC4262781__F1 Aberrant miRNA expression in liver cancer promotes cell-cycle progression CDK2 SMAD2 MYC MDM2 SMAD4 CDK4 CDC2 CDC25B RB1 PCNA CDK6 PMC12072370__F4 Knockout of StNADC has devastating effects on NAD synthesis and activates plant senescence and tuberization pathways SIRT2 NAMPT NADK HEL-S-8a ENPP3 NUDT15 SDHA NAXE SDHB PMC116060__F6 Proposed signal transduction pathways involved in PKC-mediated SRE activation ARHA RAC1 PMC4262781__F2 Aberrant miRNA expression in liver cancer affects the functionality of apoptosis pathways MYC PTEN CDK6 RFWD2 TSC2 CASP3 ATM APAF1 CDK2 CCNG1 MDM2 CASP9 BCL2 CDK4 CDC2 MCL1 ATR CASP8 PCNA BAX PMC8222170__F7 KEGG pathology and disease analysis BAD APP COMP BAX PMC3178285__F5 Proposed signaling of TNFA− and leptin-induced EL upregulation in primary placental ECs TRADD MADD LIPG LEPR TRAF2 PMC11848126__F2 MTOR signalling pathway, highlighting mTORC1 and interactions that regulate canonical initiation EEF2K ULK1 NCBP1 LARP1 CRY2 EEF2 EEF1A1 PTEN MTOR PDPK1 RHEB IGBP1 ATF4 MAF1 PMC6938856__F10 Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis CCND1 MTOR PMC11848126__F4 CK2 signalling pathway, highlighting interactions that regulate canonical initiation EIF4A1 ELF5 LARP1 CRY2 TGFBR2 PTEN EIF4G1 PDPK1 EIF3G NCK1 EIF3J EIF3S2 EIF3F ATF4 EIF4B TGFB1 PER2 PMC3030971__F1 Key proteins and pathways in the replication stress response network INO80 RAD17 ATM BLM TOPBP1 RAD52 RAD51 ATR H2AX MRE11A PMC10728939__F3 Signaling pathways regulated by BAMBI BAMBI CD14 SMAD2 TGFBR1 APC LRP5 SMAD4 LRP6 TRAF6 MYD88 TLR4 VCAM1 TCF4 PMC6523967__F1 Cyclin D1–CDK4/6–Rb pathway in breast cancer TSC2 CDK2 CCND1 CDK4 MTOR CDK6 PMC6598324__F7 The potential mechanism of FOXP3-mediated regulation of cancer cell stemness NOTCH1 HES1 FOXP3 PMC10886574__F3 Sirtuins Affect Cancer Stem Cells via Epigenetic Regulation of Autophagy NLRP3 SIRT2 SIRT7 SOX2 SIRT4 CXCR4 SIRT6 MSC TET2 TET1 SIRT3 PMC5851329__F4 Summary of Potential Eph/Ephrin Tumor Promoting Pathways FYN ERBB2 RHO PTEN RAC1 STAT3 PMC10886574__F2 The SIRT1–c-Myc axis in the control of stem cells MAX USP22 SIRT1 TERT PMC2682019__F9 A link between glucose and insulin signaling in Beta-cells IGF1 GRB2 MTOR FOXO1 PMC8267928__F5 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction CYBA SMPD2 SORD SPHK2 MGST2 XRCC5 STAT1 PLEK2 NOS2 PSMB9 LAMC2 SETBP1 MYADM RAPGEF1 PLAUR GUCA2A FUT4 MUC4 ABCA1 CD36 CD37 CEMIP TGFBR2 GIP HEL-S-7 REG3G MX2 HTATIP2 XAF1 RRM2 BIN1 HEL-S-8a ME1 RIPK3 PDK4 NR1C1 TNLG7A TNS4 HEL-S-171mP ENPP7 MGST1 PDGFC SPIB APOBEC2 TMEM171 TFF1 TM4SF4 IGSF9 EVI1 SUSD2 AADAC SASS6 YPEL2 NRG4 PMC8267928__F6 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction LY86 DHX58 BATF2 OXCT1 CRY2 TNFSF13 ACOT12 SORD ZBP1 MX2 USP18 SIRT3 SP110 OAS2 CD209 NOS2 PPT1 ME1 CTH PTGR1 PLAUR AQP1 SKIL STAT2 CXCL10 RNF186 MBL2 NR1C1 SPIB EVI1 ABCA1 ZC3H12A NRG4 MAVS CASP4 PAX8 PMC8267928__F7 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction GSTA4 PCK1 WRN RBBP8 NQO1 SIRT3 MGST2 XRCC5 PPARGC1A RRM2 GPX2 GSTM4 GSTA3 GSTM3 NOS2 LOC51064 EPHX1 GSTM1 NR1C1 GSTM2 MGST1 MAPK6 SUV39H1 HEL-S-64p ABCA1 PMC7538784__F1 Current mechanisms proposed for metformin in pathological pain TSC2 IPMK RHEB IFNG CAMKK2 PMC4854363__F3 Negative regulatory NLR functions during viral infection TBK1 IRAK1 NLRP12 NLRX1 TRAF3 TRAF6 NLRC3 MAVS PMC8267928__F3 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction CTH PLAUR STAT2 AQP1 CRY2 FES RIPK3 SORD MX2 USP18 SIM2 SP110 AADAC ABCA1 SKI PPT1 MAVS CD36 PMC7016866__F8 Model for the activation of Notch2 signaling in renal tubular epithelial cells under high glucose conditions and the possible actions of LE or LE/GC-KO in suppressing the Notch2 signaling cascade MAML1 PMC8267878__F5 Current Understanding of IL-37 in Human Health and Disease RUNX2 CCL20 RAC1 CCL3 PMC12078438__F5 NI-ADSCs activating the Notch pathway to promote nerve regeneration by inducing and maintaining the reparative phenotype of Schwann cells GFAP NOTCH1 HES1 PMC6638267__F8 Working model for the role of peroxisomes in fungal infection PEX7 PEX6 PEX5 PEF1 PEX13 PMC10875036__F5 IAV NS1 and SARS-CoV-2 Nsp1 antagonism of innate immune responses STAT2 IRF7 IRF9 IRF3 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 STAT1 ISG15 TLR7 EIF2A TYK2 JAK1 MAVS PMC3751673__F3 Ingenuity pathway analysis of the top-ranked network IL13RA2 KMO CD1A CRLF2 CCR4 NFIL3 CCL23 IL17RB CD200R1 CCL22 PMC3508196__F1 TARGETING ONCOGENIC BRAF IN HUMAN CANCER NF1 KIT ERBB2 FOS EGFR MYC PTEN MTOR PMC6721815__F2 MAPK signalling in the context of wild type BRAF and mutant BRAFV600E NF1 BRAF NRAS GRB2 USP28 PMC6721815__F3 Adaptive response-mediated resistance to BRAF inhibitors in melanoma TFEB BRAF ERBB3 EGFR GRB2 USP28 SOX10 PMC4931622__F1 The Wnt/Beta-catenin signaling pathway in renal cell carcinoma (RCC) APC GSK3B IGFBP4 VHL CCND1 WIF1 PMC7730698__F2 Role of CK1D/E in the Wnt signaling pathways GSK3B MYC LRP5 LRP6 RYK ROR2 DKK1 ROR1 FOXP3 PMC10527795__F1 Wnt signaling pathway APC LRP5 LRP6 ROR2 RHO RAC1 CDC42 PMC6160310__F1 Hepatitis E Virus life cycle EIF4A2 TUBB IRF7 EIF3A IRF9 EEF1A1 IFNAR2 EIF4E IFNG TSG101 STAT1 ISG15 IFNGR1 ACTG1 PMC7892472__F1 Key aspects of BAFF-R, TACI, and BCMA signaling within the context of CVID RELA TRAF3 RELB BCL2 TRAF2 PMC3873642__F1 A proposed model of the DNA-damage response pathway RNF8 ATM MDC1 H2AX BRCA1 PMC11204528__F8 Dicerandrol C Suppresses Proliferation and Induces Apoptosis of HepG2 and Hela Cancer Cells by Inhibiting Wnt/Beta-Catenin Signaling Pathway LEF1 GSK3B LRP5 LRP6 PMC7462918__F3 Membrane trafficking of SGLT1/Sglt1 RS1 TGFB1 SGK1 PMC4384750__F9 Model of SOX2 feedback signaling pathway SOX2 EGFR FOXO6 BMF PMC9374328__F1 c-Met: A Promising Therapeutic Target in Bladder Cancer HGF SMURF2 CREB1 SRC PMC12206656__F4 Copper is closely associated with various forms of PCD NLRP3 PINK1 GPX4 FES RIPK3 MTOR DLAT ZBP1 GSDMD PMC8072220__F8 Complex of distal appendage–associated kinases linked to human disease regulates ciliary trafficking and stability CSNK2A1 SMO CEP164 PLEKHO1 PMC3713213__F7 Signaling pathways showing mechanisms involved in the protective effects of cardiac-specific CYP2J2 transgenic mice subjected to diabetic stress CYP2J2 PDK4 ATR IRS1 PMC8066826__F2 Adiponectin and its receptors and schematic representation of adiponectin-induced signaling pathway ADIPOR1 ADIPOR2 MTOR APPL1 PMC9104939__F6 Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis TLR4 IGF1R TLR9 IGF1 SMAD2 TGFBR1 TGFBR2 BCL2 CTGF AKT3 PMC6952948__F5 The role of mTOR in glutamine metabolism and hexosamine biosynthesis MYC GLS PMC6952948__F6 The role of mTOR in the pentose phosphate pathway and nucleotide synthesis OMP MYC RPIA IMPDH2 HEL-S-70p CAD HEL107 MTHFD2 PMC7961658__F7 Possible mechanism of action of glycyrrhizin (GL) in colon cancer HMGB1 TLR4 MYD88 IL6R SOX9 STAT3 PMC9343382__F1 Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe? NAPRT NAMPT HEL-S-90n NRK PMC4386408__F5 The mechanism of the switch off in Shh canonical signaling during spinal cord development GLI3 SHH SMO PMC4994041__F7 The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis YAP1 PMC4130654__F1 PI3K-PTEN-mTOR pathway TSC2 TSC1 PDK2 RHO PTEN RAC1 DEPTOR SGK1 RHEB PMC7566413__F2 Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity CCL25 FOXP3 PMC10874556__F1 Mechanical cue-dependent scarring RREB1 ZEB2 IL33 IL11 STAT3 PMC3095361__F9 ROS, elicitor and hormone regulation of O3-induced CRKs DND1 TF PMC5581728__F2 Molecular actions of HDIs in sarcoma RARA MDM2 PTEN FUS FADD BAX PMC3116122__F1 PI3K pathway activates different processes that regulate proliferation, apoptosis and migration BAD EGFR MDM2 RHO PTEN MTOR PMC3372068__F1 Coagulation and complement cascades HEL-S-62p CS TF PMC7013859__F2 LPS recognition by toll-like receptor 4 (TLR4) CD14 TLR4 LBP IRF3 MYD88 PMC7216071__F8 Activation mechanism of miR-223 negative regulation of the TLR4/MyD88-NFKB signaling pathway NLRP3 MYD88 IL1B PMC517537__F7 Signaling kinases involved in regulation of TNFA, IL-10, and IL-6 in Kupffer cells LTA SRC PMC3428770__F2 Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt TBK1 BAD HEL-S-28 WNK1 CDC37 PTEN EIF4E TBC1D4 TSC2 TSC1 GAB2 HTT MDM2 SYK RAF1 JAK1 PMC6423427__F1 Overview of UPR signaling pathway ATF4 EIF2A XBP1 PMC8036623__F2 Proteolysis on the VEGF pathway STAT1 MMP2 PLG MMP9 PMC3587611__F8 Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo WNT3 LRP5 PGC DKK1 CTDNEP1 PMC9557158__F9 MiR-21 and let-7 cooperation in the regulation of lung cancer LIN28B LIN28A PLAG1 PMC3759196__F9 Aberrant Signaling Pathways in Glioma NOTCH2 NOTCH4 SMAD4 TRRAP BMI1 IL6 NOTCH3 OLIG2 PTCH1 GLI3 NOTCH1 SHH SMO TNFAIP3 SMAD1 DKFZp781O1323 STAT3 PMC4177022__F6 Proposed mechanism of testicular apoptotic response to x-ray exposure APAF1 BIRC3 AVEN CASP9 CASP10 CASP8 PMC3196283__F1 BER pathways BER is initiated by a damage specific DNA glycosylase and APE1 that excise the damaged base and incise the arising abasic site, respectively generating a DNA single strand break with a 5'-sugar phosphate FEN1 PCNA PMC3759196__F6 RTK/PI3K/Akt signaling TSC2 TSC1 PTEN PMC3759196__F7 P53 pathway and retinoblastoma (RB) tumor suppressor protein signaling are shown ATM DKFZp781B1423 MDM2 CCND1 CDK4 RB1 PMC3650616__F9 MEK inhibition increases lapatinib sensitivity via modulation of FOXM1 FOXM1 EGFR MTOR PMC12072112__F5 Insulin resistance, neuroinflammation, and tau pathology in Alzheimer’s disease TLR4 GSK3B MTOR PMC12072112__F1 Insulin signaling pathway regulating glucose uptake and storage MTOR IRS1 PMC12072112__F2 Interaction between insulin signaling, inflammation, and oxidative stress in cellular metabolism GSK3B GRB2 MTOR TG IRS1 PMC10757641__F1 G protein-coupled receptors and obesity GCGR POMC GHSR GIPR AgRP MC4R NTS PYY ARC GIP GLP1R PMC11983301__F2 Podocytes, renal tubular epithelial cells, and glomerular mesangial cells in DKD APC VHL TRAF6 USP25 SMURF1 TRIM29 FBXW7 GATA4 PINK1 TRIM13 RFFL TRIM63 CYLD USP22 SIRT1 FASN PMC12228841__F5 TLR2 and TLR4 signaling pathways and their interplay TLR4 IRAK1 TRAF6 IRAK4 MYD88 TLR1 TAB3 PMC4779598__F5 A proposed model illustrating how SOX4 interacts with PI3K-AKT, Wnt-Beta-catenin, and AR signaling pathways, and how the PI3K-AKT-mTOR pathway regulates the expression of SOX4 in prostate cancer progression EGF EGFR GSK3B PTEN SOX4 PMC4264417__F2 Notch receptor and pathway NOTCH2 MAML1 EGF NOTCH4 NOTCH1 NOTCH3 PMC4264417__F3 Notch–EGFR crosstalk in TNBC EGF EGFR NOTCH1 PMC4264417__F4 Notch–HER2 crosstalk in HER2+ BC (A) EGF HRG PMC8077955__F2 Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease IL16 TLR4 IGF1 IL6 MERTK TNF PMC4264417__F1 HER receptor and pathway: (A) there are four members of the HER family of RTKs: EGFR/HER1, HER2, 3, and 4 EGF PDK2 EGFR PTEN DEPTOR RHEB EED PMC5930388__F5 PI3K/AKT/mTOR pathway TSC2 TSC1 PTEN PMC2330246__F1 Overview of NAD biosynthesis and salvage pathways and a link with other metabolic pathways via ADP-ribose HEL107 RPE PMC4856023__F3 The blockade of immune checkpoints in cancer immunotherapy CTLA4 PMC4183535__F4 Maternal Obesity and Tobacco Use Modify the Impact of Genetic Variants on the Occurrence of Conotruncal Heart Defects GSTM2 RFC1 BHMT2 HEL-S-61p GSTA4 GCLC AHCYL2 GSTA3 TCN2 DNMT3L MTHFS PMC11049885__F2 Network comprised of the IRs affecting ecdysone synthesis PIK3R1 MRPL32 NINL CSNK1D MRPL44 FDX2 DAO FAM114A1 ALDH3B1 ALDH3A2 CEP78 ZFC3H1 ITM2C ONECUT1 CYP51A1 SSNA1 HTT SREBF2 ENO3 NAB2 DPAGT1 TP63 MAPK7 HBG2 HBG1 UBA3 AKR1B1 PIGK MED18 RPN1 PPP1CC HBB SOAT1 ALG14 TH EBP SC5D SHANK3 DHCR24 VKORC1 TRFP CDK4 MYOC BST2 PPP2R1B PIGN UPF2 HAUS1 GFRA2 PMC11049885__F3 Network comprised of the IRs that compete with ecdysone synthesis PIK3R1 TH MRPL32 NINL CSNK1D MRPL44 FDX2 FAM114A1 EBP ALDH3B1 CEP78 DHCR24 ALDH3A2 ZFC3H1 AKT1S1 ITM2C ONECUT1 NQO1 CYP51A1 SSNA1 TRFP SREBF2 CDK4 MYOC PNPLA3 ENO3 NAB2 DPAGT1 MAPK7 TP63 HBG2 HBG1 UBA3 AKR1B1 HAUS6 PPP2R1B PIGN RPN1 MED18 PPP1CC UPF2 HBB HAUS1 SOAT1 ALG14 UBIAD1 PMC9446423__F2 Endocrine therapy resistance: what we know and future directions TSC2 TSC1 SP1 PMC5222515__F5 Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines CHRM4 PIM1 KDR CHRM3 PGR CHRM1 EGFR NR3C1 CHRM2 NOS2 RXRA PMC2796982__F3 Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway DAAM1 FZD3 APC WNT1 RHO CDC42 PMC11049885__F6 Key IRs significantly affecting ecdysone synthesis FDX2 EBP SC5D SREBF2 PMC7404026__F1 Canonical and non-canonical Nuclear factor kappa B (NFKB) signaling pathways TRADD RELB LTB TRAF6 MYD88 BTK LTA BCL10 BCR RELA LCK ZAP70 CD40 SYK REL TRAF2 PMC6005692__F11 HIV-1 gp120 up-regulates BDNF expression in BV2 cells via Wnt/Beta-catenin signaling pathway APC TEF LRP5 LRP6 PMC8338882__F2 HPV immune modulation of the tumor microenvironment HLA-E CD80 FOXP3 PMC7290828__F1 Mitochondrial Protein Quality Control System (MPQC) PINK1 CLPX OMA1 MIP HTRA2 CLPP PMC3732602__F1 TGFB signaling TGFBR2 RHO RAF1 PMC8621451__F5A Positive Salt Tolerance Modulation via Vermicompost Regulation of SOS1 Gene Expression and Antioxidant Homeostasis in Vicia faba Plant SOS2 HEL-S-11 SOS1 PMC3732602__F5 TGFB processing and uPA-uPAR-dependent activation PLG FURIN PMC10140933__F12 Pathways of protein synthesis and transport activated by CsRALF34 overexpression (based on the KEGG signal pathway database) VAMP7 GCN1 PMC3240715__F3 Molecular mechanisms of FGFR3 signaling in cartilage STAT1 IHH SOCS3 FRS2 LIF GRB2 FGFR3 CNP IL6 SOS1 SOCS1 STAT3 PMC8100490__F7 Zearalenone exposure affects the Wnt/Beta-catenin signaling pathway and related genes of porcine endometrial epithelial cells in vitro APC GSK3B LRP5 SMAD4 CCND1 LRP6 XRCC3 USP1 PMC4409267__F1 Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation PDC PC ACAT1 ACAT2 PMC2999931__F2 Postsqualene cholesterol synthetic pathway LBR DHCR7 EBP SC5D DHCR24 HSD17B7 PMC7248321__F5 Multiple signaling networks are regulated by hsa-miR-205-5p based on ingenuity pathway analysis (IPA) ACVRL1 MYC MARK4 SLAIN2 FLNB MDIG BMF HAUS8 DKFZp686F0183 PHETA2 CDC42BPA SPIRE1 MIA3 PLXNB1 KIF13B DDX11 KITLG FERMT2 PHF20 MKI67 FIS1 INPPL1 AREG GSTM1 ABI2 CHCHD3 PDK4 HYOU1 POLDIP3 NEK6 MID1 ELF3 CDC42EP3 NCAPG RELA SERINC3 NOX5 RAN CSF1 PMC7149230__F5 Synchronization of central carbon enzyme and metabolite abundance with cell cycle phases HEL-S-49 ACO2 ENO2 CIT HEL-S-32 MAL PMC6760157__F6 Cystathionine Beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter EPOR FECH EPO ALAS2 PMC3784205__F6 Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans PDK2 CPT2 TFAM PNPLA2 PMC2729268__F2 Map of protein interactivity (binding, regulation, modification) between genes revealed to be significantly associated with bladder cancer in urothelial cell samples HHIP AMFR ERBB2 TGFBR1 BMP7 LRP8 ATF3 LEPR TFRC GNB1 APOE F11R PMC5661256__F7 Schematic diagram of a signalling pathway related to anti‐apoptotic or anti‐inflammatory effects of polydatin on LTA‐induced injury CASP3 LTA CASP9 PMC4625495__F1 Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury ARHA IL6 PMC4389564__F1 CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6 CXCL1 CXCR4 CD44 LRP6 PMC8942208__F3 Differentially expressed components of four of interesting pathways involved in immune response and drug metabolism in F. gigantica-infected hLNs and pBLs GSTA4 MPO CCR3 ALDH3B1 IL17F CXCL3 CD1E IL18 AZU1 GP5 MAPK12 CCL17 GSTA3 CXCL6 IL4 FGA IL1A CFB FOSL1 IL13 PTGS2 LIF MMP9 CXCL10 IL6 TNF IL12B NCR1 IL23A LBP PLA2G4F INHBB PMC4255043__F1 Induction of nuclear factor-activated T cells c1 (NFATc1) in osteoclasts MAFB IRF8 NFATC1 HEL-S-11 GSK3B OSCAR TRAF6 SIRPB1 PMC10931359__F3 S1PR signaling pathways in liver regeneration and HCC progression S1PR2 S1PR1 S1PR3 RHO PMC7486245__F1 Components of the TgfB signaling pathway that have been implicated in cardiomyocyte proliferation SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7669638__F2 Molecular Regulation of Cdk5 activity EGR1 FYN NGF CDK5 GDNF BDNF PMC4104512__F4 Functional zonation of the rat adrenal cortex: the development and maintenance ZFR CYP11A1 CYP11B2 PMC6902440__F4 Interactions of TGFB pathways, WNT, Smad and the Hippo pathway in fibrosis LATS1 PTEN LATS2 PMC6902440__F2 TGFB1 effects on the balance between the canonical WNT/Beta-catenin pathway and PPARG SMAD2 APC LRP5 SMAD4 LRP6 DKK1 PMC6910186__F8 Roles of miR-21 and the PDCD4/c-Jun signalling pathway in renal cell carcinoma MMP2 MMP9 VEGFA PMC3303581__F1 Myostatin signals through the ActRIIB-ALK4/5 heterodimer activate Smad2/3 with blocking of MyoD transactivation in an autoregulatory feedback loop IGF1 SMAD2 MTOR RHEB PMC5363987__F8 CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy EREG ERBB4 CUZD1 PRLR PRL PMC6487484__F1 Mechanisms Linking Mechanotransduction and Cell Metabolism ARHA PMC10686715__F2 Exosomes from different MSCs mediate PCD in myocardial cells after myocardial infarction NLRP3 STEAP3 MSC TRAF3 PTEN MTOR DKFZp686F0183 BAX PMC6487484__F2 Mechanisms Linking Mechanotransduction and Cell Metabolism ARHA PMC4367964__F5 Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta HMGB1 MUC1 SNAI1 CIAO1 DDB1 TICAM1 MMP3 NLRP3 ITGAM IL18 TLR4 RPS6KB2 PYCARD IL1B SNRNP200 CASP4 PMC10686715__F4 Angiogenic effect of exosomes released by different MSCs after MI TH PRSS23 HGF MSC EFNA3 PMC4229635__F6 Shed Sdc-1 induces the activation of EGFR and downstream signalling pathways via sHB-EGF MMP7 MMP9 EGFR HBEGF PMC10686715__F5 Exosomes secreted by different sources of MSCs regulate the inflammatory microenvironment after myocardial infarction MSC FES EZH2 BCL2L11 BCL6 PMC8599300__F4 Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome CD14 MAPKAPK2 SOCS3 A2M CRP LBP TNF TRAF2 SOCS1 STAT3 PMC5786332__F6 HIV replication in monocyte derived macrophages (MDM) by steroid hormones CXCL10 IFNB1 TNF IFNAR1 IL12B IL15 IKBKB IFNA13 CXCL9 IFNA2 IL1B CXCL11 CCL3 PMC4196580__F6 Toll-like receptor signaling pathway showing the annotated and non-annotated proteins CD14 CTSK TLR9 CD6 TRAF6 IRAK4 RAC1 TLR3 CPO LBP CD40 FADD TIRAP PMC4196580__F7 B cell receptor signaling pathway showing the annotated and non-annotated proteins CD72 BCL10 BCR BASH GC CD22 LYN SYK CD19 PMC4196580__F8 T cell receptor signaling pathway showing the annotated and non-annotated proteins ITK FYN BCL10 LCK GRB2 CD48 CDK4 LAT CBL PMC4196580__F9 Chemokine signaling pathway showing the annotated and non-annotated proteins ITK RHOD SHE REL DOCK2 CRK ELMO1 PMC8755678__F3 Endothelium function by fatty acids CPT1A DLL4 MYC VEGFA NOTCH1 KLF2 FOXO1 PMC3489747__F2 TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis TBK1 IRF3 COMP FADD PMC7473858__F8 Pathway modeling for genome signaling and metabolic reconstruction revealed the pathological mechanism of oral cancer using KEGG and Wiki pathway databases PTEN BAX PMC7028849__F8 Schematic illustration on possible roles of aminooxyacetic acid (AOAA) on macrophage metabolism and polarization PFKL TNF CD36 PMC7281956__F10 The ROS/PARP/TRPM2 signaling pathway that mediates SiNPs-induced pulmonary inflammation in mice CXCL1 SQSTM1 CXCL8 TRPM2 PARG PMC9621617__F4 Alterations in bone fracture healing associated with TNFRSF signaling pathways RUNX2 NFATC1 MSC FADD PMC2799380__F6 Connective tissue associated signalling network common to various cardiac hypertrophy animal models and human cardiac disease FBLN2 CS COL3A1 ATP1A1 SLC7A1 SMAD2 EGFR SMAD4 ASPN COL1A1 SERPINE2 IGFBP5 OSMR SULF1 COL14A1 TIMP1 COL1A2 APP KLF9 PMC11053956__F6 JAK/STAT signaling pathway mapper PIG59 USP21 TRADD FES TNF TLR3 ZBP1 NLRP3 TLR4 CYLD IL33 H2AX OSM FADD MLKL PMC7428229__F7 DEGs mapped to the cysteine and methionine metabolism pathway in shoots ADI1 MRI1 APIP SMS PMC8176883__F3 Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research MYH9 RTCA GIGYF2 PMC7300268__F4 YAP/TAZ regulation by lipid metabolism and YAP/TAZ-targets for Lipid metabolism ARHA LPA HMGCR PMC6161735__F1 Nrf2/Keap1 signaling pathway in homeostatisis and stress MAF KEAP1 PMC3251842__F2 TGFB response pathway SMAD2 SMAD4 TF PMC5817727__F4 Regulation of PTEN, a major regulator of the PI3K/AKT signalling pathway EGR1 ATF2 PTEN PMC9412181__F1 Overexpression of enzymes in glycolysis and energy metabolic pathways to enhance coenzyme Q10 production in Rhodobacter sphaeroides VK-2-3 MVK GCK ADPGK OGDH ACLY DLAT SDHA HEL-S-162eP PMC5831902__F3 The calcineurin/NFAT signaling pathway and the miRNAs involved in feedback loops to modulate the pathway activities HOMER2 LRRK2 AKAP5 MAP3K7IP1 ORAI1 STIM1 DYRK1A PMC6862668__F1 Signaling pathways and therapeutic targets BMP10 VEGFA ENG PTEN PMC5348387__F6 Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis BAD DIABLO BAX PMC5734142__F1 Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer RET CDK2 CDK4 CDC2 CDK6 PMC4009444__F2 Intracellular signaling pathways for hepcidin expression BMP6 HFE IL6 SMAD1 DKFZp781O1323 PMC4397969__F1 (De-) Oiling Inflammasomes DKFZp686L0365 NLRP3 MYD88 MAP3K7IP1 IL1B PMC8226720__F1 An Overview on Diffuse Large B-Cell Lymphoma Models: Towards a Functional Genomics Approach TNFRSF14 DTX1 IRF8 IL6 TET2 BCL6 EP300 CD27 BCR TNLG8A BTG1 CCND1 CD40 EZH2 TNFAIP3 SGK1 MLL2 PMC8848207__F1 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy TSC1 EGFR EIF2A UVRAG DKFZp686F0183 STAT3 PMC8848207__F2 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy LAPTM4B ATG3 EGFR MTOR STAT3 PMC9177660__F2 NcRNAs implicated in regulation of ferroptosis GPX4 ASCL4 SLC7A11 PMC8879474__F5 Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease APC IFNG PMC9685814__F2 From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders ACHE BCHE BDNF PMC6597757__F2 Illustration depicting primary signalling mechanisms of different neuronal and astrocytic proteins encoded by genes implicated in ID/ASDs SHANK3 MTOR PMC8558397__F1 Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges APC EGFR PMC4329815__F3 Signaling pathways implicated in hyperstimulation of macropinocytosis and vacuolization of macropinosome-derived compartments PAK1 NGF ARF6 PMC8467255__F4 Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer’s Disease Patients: Getting Clues from Proteomic Studies APOA4 ABCG5 ABCG4 ABCG1 APOC2 LDLR ABCA1 CD36 PMC7760556__F1 Possible pathways for immunogenic activation in response to autologous iPSCs-whole cell vaccines CD40 DES HEL-S-92n CD80 PMC4065631__F2 Ligand bias prevents class equality among beta-blockers ARG2 ARG1 PMC8432812__F5 Proteogenomic analysis of pancreatic cancer subtypes TLE3 RNF43 DKK3 APC NRARP TEC PTEN MTOR RPTOR DKK4 RHEB TSC2 RICTOR TSC1 EP300 COPE HEL-S-11 STK11 SPEN AKT3 PMC5825871__F9 Role of Gpr161 in forelimb initiation, limb patterning and skeletal morphogenesis IHH RUNX2 PTCH1 GPR161 GLI3 FGF10 SHH TBX5 PMC10525532__F4 Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential NLRP3 TXNIP IL1B PMC3879708__F2 Upstream nutrient signaling to mTORC1 and AMPK TSC2 TSC1 BNIP3 RHEB PMC8507803__F2 Good Cholesterol Gone Bad? HDL and COVID-19 APOM APOB ABCG1 PON1 ABCA1 TG PMC3966329__F1 Regulation of autophagy by ARV TFEB EIF2A PTEN PMC8009859__F1 Illustration of proposed MB related proteins/pathways described in this review. (i) Conventional MB-related signaling pathways PDE4D WEE1 SUFU APC GSK3B SRC SMO SP1 MTOR PMC8474995__F1 Is there a place for cellular therapy in depression? NLRP3 GC CRP PMC5657612__F10 The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease PICALM AQP4 CD36 PMC8172449__F1 NAD metabolome and metabolic pathways NAMPT NNMT TPO CYP2E1 NAXE NRK HEL-S-162eP HAAO HEL-S-90n NMNAT1 KYNU KMO NAXD AFMID SARM1 PMC5851940__F5 Highlighted genes to represent a single pathway ITGAM ARHH CXCR4 TEC ARHA ITGA4 RAC1 ITGB1 CDC42 PMC5851940__F1 Biological pathway of Leukocyte Transendothelial Migration () CD99 ARHH RAE1 TEC JAM3 ARHA RAC1 JAM2 THY1 TOB2 PMC7949067__F3 Relevant pathways of the unfolded protein response (UPR) BAD EIF2A XBP1 BAX PMC7369379__F7 C-P-T network of top 20 pathway PRKCA CHUK PLAT RELA CCL2 JUN NR1C1 RXRA BAX PMC5432641__F2 Nucleotide excision repair and the ATR-CHK1-mediated DNA damage checkpoint TIMELESS TOPBP1 ATRIP XPC XPA ATR PMC10965438__F1 Nanomaterials modulating TAMs for the treatment of GC NPS CD163 CD80 DUSP2 STAT3 PMC5980186__F5 Proposed model describing the regulatory pathway between Smad7 and hepcidin expression in hepatocytes BAMBI BMP6 SMAD6 SMAD4 HFE SMAD1 DKFZp781O1323 PMC10965438__F6 Nanomaterials modulating TAM polarization for the treatment of HCC via the STAT signaling pathway STAT1 CD163 CD80 STAT3 PMC6097550__F1 NRAS mutant melanoma: an overview for the clinician for melanoma management NRAS CDK4 CDK6 PMC10965438__F7 Nanomaterials modulating TAMs polarization for the treatment of HCC via the NFKB signaling pathway STAT1 CGAS TLR5 TLR7 NPS CD80 PMC5429649__F11 The mechanism of Salvia fruticosa-induced relaxation of rat isolated aorta COX2 COX1 PMC6154840__F1 PKCι drives both common and lineage-specific oncogenic pathways in lung cancer MMP10 PAK1 SOX2 ELF3 ECT2 SUFU PTCH1 SHH SMO RAC1 PMC5976231__F5 Vascular wall resident Sca-1+ progenitor cell migration in response to chemokines and lipoproteins CXCL1 CCR2 MMP9 IL8RB CCL2 RAC1 CDC42 STAT3 PMC10846380__F6 CK1A degradation by FPFT-2216 and subsequent p53 pathway activation and CBM complex/NFKB pathway inhibition CARD11 BCL10 MDM2 DDB1 CUL4A CRBN PMC11786022__F7 Mechanism of TGFB activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation CDK2 CDK4 CDC2 CDK6 PMC3572906__F3 Microbial Cell Components Induced Tolerance to Flagellin-Stimulated Inflammation through Toll-Like Receptor Pathways in Intestinal Epithelial Cells CD14 MAP3K1 CXCL10 IRAK2 IRAK4 IRF3 MYD88 HEL-S-31 BTK ECSIT TRAF2 JUN FADD TIRAP PMC12135143__S1 Biosynthetic pathway of IMP (Adapted with permission PURB PMC8192774__F3 Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors KPG_011 COL3A1 GPT KCNV2 POLR2F PPBP KRT6B GNAI1 CEACAM1 GABRB3 PNOC F2 DEFB129 DEFB128 GIMAP4 APOBEC4 TRHR TAAR9 VNN1 KRT71 TAAR6 DEFB136 TAAR5 KCNAB1 CACNA2D2 DEFB134 TAAR2 VNN2 KRT73 SST CEACAM3 RXFP4 PVALB ACTA1 GATA4 SIRPA POLR3G PECR URI1 SERPINF2 PMC12016470__F8 Sildenafil promotes osteogenic differentiation of hMSCs and suppresses bone loss by affecting TGFB signaling SMAD2 SMAD4 PMC5322168__F5 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort IL21R DUSP4 RUNX3 NFATC1 CXCL10 CXCR5 ID3 FOXP3 IFNG SELL GIG8 CAMK4 CXCR4 STAT4 ZAP70 CCR7 IL6ST IL-21 RORA CDH2 ICOS STAT3 PMC9264955__F6 Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis TSC2 TSC1 GRB10 DEPTOR RHEB MLST8 PMC4740345__F3 Sirolimus and CNI impact on insulin signaling pathway YY1 IRS1 PMC5322168__F4 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort IL21R RUNX3 CD74 CD69 IFNG SELL BCL6 IL15 STAT1 PIK3C2B GIG8 BCR CD2 STAT4 CCR7 IL7R IL2RA IL6ST IL-21 IL4 TRIM5 ICOS PMC3648498__F3 Alzheimer’s disease pathway from the KEGG database CASP3 SNCA CASP12 BAD AGER LPL CASP9 APP TNF FADD PMC7305909__F1 Virus-based and host-based targets against the coronavirus replication cycle DPP4 FURIN ACE2 TMPRSS2 HEL-S-69p PMC12102949__F2 Illustrates Various Molecular Mechanisms Facilitating the Formation and Survival of DTPs under Targeted Therapy and Immunotherapy ChAT GPX4 SOX2 FOXM1 ASCL1 APOBEC3B SETDB1 FGF2 NPC1L1 MTOR ARID1A SMARCC1 APOB SMARCA4 POLE OGT GRB2 EZH2 MED1 BRD4 PMC12102949__F3 Multiple Cross-linking Mechanisms among Tumor Cells or/and the Surrounding Environment Sustain the Formation and Persistence of DTPs under Targeted Therapy and Immunotherapy CXCL1 CCL11 HGF OIT3 FGFR4 MTOR IFNG CD27 TNLG8A CXCL12 TNLG5A TF FGF7 PMC10932085__F1 TRPs modulate inflammation in immune cells TRPV4 TRAF6 TRPM5 MTOR TRPM7 TRPV1 FOXP3 STAT1 NLRP3 TRPC1 TRPC6 TRPC3 TRPM2 STAT3 PMC10932085__F2 TRPs modulate anti-inflammation in immune cells TRPC5 TRPV1 TRPM8 PMC6824679__F2 Synthesis of phosphatidylinositol and acyl chain remodelling TAMM41 PC PGP LPA TG MBOAT7 PMC5103281__F2 Mechanistic cycle for silyl-mediated cross-coupling SET ALK PMC4295872__F8 Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation CASP3 BAD ERBB2 PSMC3IP EPSTI1 EGFR CASP9 CASP8 FADD PMC4999690__F1 GM-CSF and IL-6 signaling MMP9 JAK1 CDK9 STAT3 PMC6356072__F4 Protein-protein interaction networks among differentially expressed proteins ALB MAOA XXYLT1 FKBP2 NF1 MFN2 IFT74 ACADS SUCLG2 SNRPA1 OPA1 ACTR2 COL18A1 SPARCL1 VDAC3 CMC4 AGPAT5 SNAPIN ABAT FARSB YLPM1 BANF1 UBXN6 COXFA4L2 LMO7 UBE2M PTN GMDS DPP4 TPR SLC22A2 EIF3J PTPRS FH ACO2 LETM1 RPL26 GNAZ ACTN4 DLAT RHOB NDUFB6 CHCHD6 SLC6A13 NDUFS6 NDUFV2 DNAJC5 MRPL47 SLC25A4 PS1TP5BP1 CDIPT CPT1A AGL COL4A1 CLYBL HSPA2 AASS PPP1R18 HEXIM1 AQR LIMA1 EIF3E HEL-S-78p HEL-S-2 SLC2A3 FZD2 NFU1 ACAN CAPZB ETFA SLC19A1 NAAA FGA HCFC1 ABCB7 TES RAPH1 NUCKS1 RAB31 ABHD11 AK4 TIMCC NRGN CPNE3 HRAS LAMA4 EARS2 SHISA7 SSBP1 BTF3L4 HSPA4L PITRM1 ADAR RPL17 AIF1L TRIAP1 C1QTNF5 SBSPON FN3KRP MTIF3 MIEN1 IARS2 ETHE1 SLC35A4 FYCO1 IRGQ FAM98B APOH ABCE1 UBAP2L DYNC1H1 PDIA4 A1BG PFKM CCT8 NDUFB10 ALG6 GBP3 SMU1 CSPG4 KDM1A GGCX SLC25A5 CISD1 SYNPO PDPN NMT1 ARPC5 PEX3 NID1 QK3 DNCL1 LAMB1 EIF3F TRAPPC4 BAG5 CYCS ACADM APPL1 CAMKK2 PMC5288241__F2 Prostate cancer and the unfolded protein response ATF4 EIF2A TRAF2 PMC12200665__F9 TPA-induced activation of a PKCD/RIPK4/IRF6 signaling pathway inducing lytic EBV reactivation and epithelial cell differentiation in EBV-infected NOKs dik KLF4 IRF6 PMC4066235__F4 microRNAs in Cancer Cell Response to Ionizing Radiation ATM CDK2 MDM2 CDK4 ATR H2AX PMC4066235__F5 microRNAs in Cancer Cell Response to Ionizing Radiation WEE1 ATM CCNB1 MDM2 CDC2 ATR H2AX PMC4066235__F7 microRNAs in Cancer Cell Response to Ionizing Radiation CASP9 MCL1 CASP8 FADD BAX PMC2721360__F2 Colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition CTSO APC NFE2L2 MYC SMAD4 HIF1A WIF1 HEL-S-130P PRNP RARA ITGB4 AXIN1 FHL2 MAP1A PMC3488108__F1 Immune-Neuroendocrine Integration at the Adrenal Gland: Cytokine Control of the Adrenomedullary Transcriptome STAT2 IFNG STAT3 PMC3014093__F3 Upper panel LIG1 WRN PMC6991964__F8 EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria LTA CCL2 TNF EPHA2 PMC12049823__F1 Genetic regulation of SPP1 regulated by TFs and the signaling pathway in disease RUNX2 CD44 STAT3 PMC6288187__F1 Vasorin 3D structure: Cartoon representation of the structure model of Vasn predicted by RaptorX (http://raptorx.uchicago.edu/) NUMB SMAD2 SMAD4 ADAM10 VASN ADAM17 PMC5951947__F4 An illustration of the PI3K mutant, ER+ breast cancer network BAD IGF1R FOXO3A CDK2 MYC BCL2 CDK4 PTEN MCL1 CDK6 PMC7187888__F6 Danqi Pill (DQP) targeted on HIF-1A/PGC-1A signaling pathway and finally elevated cardiac energy metabolism in the failing heart NRF1 VHL PDK4 TFAM NR1C1 UCP2 RXRA PMC7189569__F4 TNF signalling pathway TRADD APAF1 MADD PTGS2 TRAF3 TNF TRAF2 FADD PMC10418884__F10 Regulatory pathway of GR GC SRC PMC7390836__F4 DSGs That Are Driver Genes of the CRC Pathway(A) Mapping of DSGs in the CRC pathway from KEGG EGF BAD AREG POLK ERG EGFR APC MYC SMAD4 ARHA MTOR HRAS CASP3 RPS6KB1 MAP2K1 MSH6 CASP9 MSH3 MSH2 SOS1 PMC8976061__F4 Biosynthesis of the phosphonate antibiotic argolaphos A (3) ALPL ALPG ALPI PMC4066235__F3 microRNAs in Cancer Cell Response to Ionizing Radiation EGFR PTEN MCL1 BAX PMC5585627__F3 Sphingosine-1-phosphate (S1P) in estrogen receptor- (ER-) positive breast cancer EGF EGFR ABCC1 SPHK1 ABCG2 MTOR PMC10522371__F7 KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling MMP2 MMP9 KIF18A PTEN PMC5442653__F3 Potential usage of nanoparticles for splenic targeting RAB8A PTEN MTOR AKT3 PMC8234716__F3 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives NLRP3 COX2 VCAM1 PMC8234716__F2 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives STAT1 IL18 PTEN STAT3 PMC7840310__F6 Cell cycle program in cell death and metamorphosis CD47 MMP14 MMP2 VTN MMP11 MMP9 CD44 VWF CHAD CD36 PMC4818578__F1 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? PIN1 IGF1R IGF1 FOXO3A MDM2 HMOX1 PMC8104092__F6 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication SRC RGS2 PMC8455272__F8 TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease MRC1 CXCL16 CCL21 CCL19 NOS2 CSF2 ARG1 PMC8104092__F7 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication BTK PC CSK GSK3B RAF1 ADRBK1 PMC7198260__F2 Ectopic lipids in insulin resistance PC IRS1 INSR PMC4818578__F2 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? IGF1 VCAM1 NOX4 NOX5 MTOR PAH PMC6974395__F3 Fumarate hydratase in cancer: a multifaceted tumour suppressor KEAP1 FH FES ACO2 ISCU NFU1 BOLA3 BOLA1 PMC6825568__F7 Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response TOPBP1 GSK3B ATR PMC8104092__F5 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication GRB2 SRC RAP1GAP STAT3 PMC9410784__F2 Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma ATF2 TNF PMC9221191__F2 Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response FADD BAX PMC8004373__F7 Interaction network of CXCR family proteins (cBioPortal) SPR GNE CXCR1 NPR2 ACKR3 PIK3CA IL8RB GNB4 PMC8932232__F1 Store-operated Ca2+ entry in cardiovascular disease IL13 ORAI1 STIM1 PMC7538683__F5 Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer ME1 GDA SMAD4 PTEN PRH2 CDK7 TSC2 ATM CDK2 ATR SIVA1 PCNA SKP2 MYT1 PMC4494932__F6 Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells AFP CXCR4 SRC PTEN MTOR PMC9623297__F2 Regulatory roles of circular RNAs via autophagy in ischemic stroke TSC2 TSC1 GSK3B BNIP3 RHEB PMC5056854__F5 PPAR signaling pathway upregulated in LCMUFA group compared to control (FDR < 0.01) and olive oil group (FDR < 0.01) UBC PLTP HEL-S-28 LPL PMC11020458__F4 Direct osteogenic effects and mechanisms of RE NMs FAM53B TBCE APC GSK3B TEF SMAD1 DKFZp781O1323 PMC7379200__F3 MicroRNA (miRNA) regulation in the maintenance of male hormonal balance POU2F1 GLI3 MEIS1 GLG1 DSC1 PTEN RNF4 ABCA1 STAR PMC4365602__F7 This schematic shows the numerous pro-inflammatory mediators produced by peri-implant tissue and immune cells reacting to implant debris, which can negatively affect bone turnover IL18 IL16 IL1B PMC3171751__F3 Altered gene expression during pressure overload hypertrophy CRHR2 EBI3 DEDD VAMP4 ABCB11 COL1A1 BATF CPB2 MAPK12 IER3 CHKA GDF15 CDC27 MAP3K8 ATP2A2 OXT LPP GNAL CSA2 TAF4B JUN VRK1 PLAG1 STAT3 PMC11950169__F6 Key mechanisms involved in TTFields-induced activation of AKT BAD ARHA CDH2 PMC5107467__F7 Amide-linked local anesthetics induce apoptosis through apoptotic pathways (the extrinsic death receptor pathway and the intrinsic mitochondrial pathway) and MAPK pathways in human non-small-cell lung cancer cells CCND1 FADD BAX PMC11815446__F1 Metabolic pathway of Clopidogrel CYP2B6 CYP2C9 CYP2C19 CYP1A2 PMC7038167__F5 Graph of genes and processes involved in the pathway 04110: Cell cycle E2F4 SMAD4 DBF4 ORC3 CDK7 ORC2 CDC20 CDC6 CDK2 MDM2 PCNA SKP2 MYT1 PMC3107509__F1 Wnt signaling pathways WNT1 ARHA PMC8197977__F3 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer AOX1 NAMPT NNMT PMC3989729__F7 A schematic diagram illustrating the interplay between TLX and the BMP-SMAD signaling pathway in the regulation of neurogenesis and astrogenesis GFAP SMAD4 BMP4 PMC8438703__F1 Understanding microglial diversity and implications for neuronal function in health and disease CX3CR1 ADAM10 AXL PMC2567511__F1 The tetrapyrrole pathway in plants showing intermediates and genes analyzed in this study UROD UROS POR CPO PMC9159374__F3 Amelioratory Effect of Resistant Starch on Non-alcoholic Fatty Liver Disease via the Gut-Liver Axis TLR4 PYY TG PMC8197977__F1 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer NAPRT NAMPT HEL-S-90n NNMT NRK PMC6542994__F1 Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome TH CDA MAX NTS NR1C1 PMC5624455__F4 Leukocyte extravasation signaling pathway altered by a high-fat-diet, Taeumjowitang, and green tea in the epididymal white adipose tissue TH FER VASP ARHH CD44 ARHA ITGA4 ITGB1 CRK PXN JAM2 PMC9229764__F2 Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review APC CD80 ACE2 PMC9471015__F1 Applications and prospects of genome editing in plant fatty acid and triacylglycerol biosynthesis PDC PC LPA PMC5881172__F1 Unfolded protein response SP2 ATF4 SP1 XBP1 PMC7830093__F1 Comparative view of wild-type p53 function in ESC maintenance, differentiation, and somatic-cell reprogramming of human and mouse: ESC maintenance: p53 is maintained in an inactive state in both human and mouse ESCs SOX2 DKFZp781B1423 MDM2 KLF4 LIN28A TRIM24 SIRT1 AURKA PMC7184931__F1 This schematic diagram shows the metabolic pathways controlling activation and lineage specification in the immune system SLC1A4 VLDLR AHR LDLR CD44 RAB4A JAK1 NDP STAT3 CD36 FOXP3 PMC9328443__F7 SNPeffect: identifying functional roles of SNPs using metabolic networks ME2 IPP PMC7184931__F2 Metabolic control of T-cell related to tryptophan metabolism TH AHR APC MTOR PMC9328443__F6 SNPeffect: identifying functional roles of SNPs using metabolic networks RGR DAP PMC9410115__F1 Pathophysiology of Coagulation and Emerging Roles for Extracellular Vesicles in Coagulation Cascades and Disorders PLG APC VWF TF PMC9328443__F3 SNPeffect: identifying functional roles of SNPs using metabolic networks RGR PMC6278486__F3 High-energy donor UDP-GlcNAc is provided by the hexosamine biosynthetic pathway (HBP) and is connected to UDP-GalNAc and CMP-NeuAc GNE NANS OGA OGT NANP PMC4516432__F5 Models for pre-miRNA uridylation by TUT7 Pre-miRNA uridylation by TUT7/4/2 in microRNA biogenesis pathway AGO2 TUT4 TUT7 PMC6345743__F5 Comparing ECM-receptor interaction pathway for (a) DA and (b) non-DA neurons based on DEGs and DEmiR TH SV2B ITGB1 COL1A1 LAMA3 LAMB1 HEL-S-11 THBS3 SI opn RELA CHAD THBS1 GAL COL9A1 COMP CA7 LAMC2 AGRN PMC6311498__F1 Cartoon illustrating the intracellular distribution of ATP7A, ATP7B, and DBH ATP7B DBH ATP7A PMC3132612__F2 The major signal transduction pathway in the ER stress response ATF4 TRAF2 XBP1 PMC7184931__F3 cGAS-STING-IFN pathway activation in SLE CGAS TREX1 SLC19A1 PMC2797892__F10 Pathway induction after pathophysiologic stimulation of BSMC by three coordinate stimuli: strain, hypoxia, and damaged matrix EIF4E MTOR STAT3 PMC3677627__F5 Molecular network based on some key metabolites reversed by resina draconis or isosorbide dinitrate treatment PDE11A GRK4 PDGFD RLN3 UCN3 RAMP3 GPR39 PMC5742900__F3 Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals AHR DIO1 PMC5742900__F4 p53 signaling pathway and related significant changes observed in response to postprandial serum (orange: upregulated compared to fasting serum; green: downregulated compared to fasting serum) MYC PIGS PTEN MTOR RFWD2 RAI1 TSC2 SIAH1 PERP ATM CDK2 MDM2 ATR PMC5887474__F3 Canonical p53 DNA damage response pathway PLK1 CDKN1A CCNB1 GADD45A AURKA PCNA PMC3067813__F7 Model of proposed HEB, GATA3, and Notch1 interactions NOTCH1 GFI1B GATA3 PMC5426948__F2 Proposed signalling pathway showing that genetic loci deregulated through altered methylation in Beckwith-Wiedeman syndrome are upstream of pheochromocytoma-paraganglioma susceptibility genes NF1 RET NGF MYC VHL MEN1 SHE MTOR PMC9425815__F1 Involvement of host microRNAs in flavivirus-induced neuropathology: An update TBK1 NFKBIA CCR2 SMAD6 IRF3 MAP3K7IP1 TAB3 PMC9425815__F4 Involvement of host microRNAs in flavivirus-induced neuropathology: An update TRAF6 EZH2 SOCS5 BACH1 PMC3675946__F6 Cell wall integrity (CWI) signaling pathway with transcriptomic expression changes during limonene stress GSC2 ROM1 HMFT1766 HEL-S-68p PMC9425815__F3 Involvement of host microRNAs in flavivirus-induced neuropathology: An update RNF11 NRF TRAF3 EEF1A1 PTEN RNF125 STAT1 TRIAP1 TLR7 NOTCH1 TNFAIP3 SOCS5 IRF-1 MAVS STAT3 PMC7904692__F1 Antiviral pathways in silkworm AGO2 EGFR PTEN PMC6713920__F3 The schematic flow of biosynthetic pathway of DNJ in S C6 ADM PMC8108589__F3 LRP-1 modulates neurodegeneration and neuroregeneration IL16 NGF TRADD TRAF1 TRAF2 FADD PMC7534062__F8 Schematic diagram depicting the effects and mechanisms of TPH-1 against renal fibrosis and the regulation of PAA on TPH-1 expression TPH1 APC AXIN1 PMC8108589__F1 Proinflammatory pathways regulated by LRP-1: The interaction between LRP-1 and ApoE represses the formation of IRAK1–TRAF6 complex and therefore the NFKB-mediated pathway IL16 TLR4 IRAK1 TRAF6 IRF3 CCL2 MYD88 APOE PMC8667344__F1 Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor IL5RA APC IRF4 GATA3 FOXP3 PMC7074087__F7 PC inhibitor attenuated glycolytic shift and metabolic reprogramming in pulmonary hypertension PC GSK3B PAH HEL-S-133P PMC5710802__F3 RLR-mediated RNA sensing pathways IL10 TANK TRADD IRF7 RIGI IL6 FADD MAVS PMC8774167__F1 Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance ATG3 MTOR PMC11660554__F5 Alterations in the HSV-1-associated host antiviral signaling pathway in HGFs IRF7 HEL-S-99n MAVS PMC6410042__F6 Pathway analysis for PRR and IFN signaling IFIT3 INA FITM1 IFITM3 IFITM2 MYD88 MX1 IFNG RNASEL STAT1 RARB OAS1 TLR7 TLR4 NOD1 FRK IRF-1 PSMB8 STAT2 IRF9 TNF TLR3 IFI35 SOCS1 IFIT1 PMC12241104__F1 Biosynthesis of shikimate PTS HEL107 PMC8651602__F2 Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis PYCR2 PRODH HIF1A CIT TET2 PMC3316122__F2 Schematic model depicting activation of the AIM2 inflammasome by F IRF3 IFNAR1 AIM2 IL1B PMC8954241__F4 Toxic Mechanism and Biological Detoxification of Fumonisins TRADD TNF MTOR DKFZp686F0183 FADD BAX PMC7885408__F9 Role of SIK1 in the transition of acute kidney injury into chronic kidney disease APC GSK3B LRP5 LRP6 SIK1 PMC10296498__F1 IL-33/ST2 signaling pathway activation IL33 TRAF6 MYD88 PMC2262896__F6 Interferon signaling STAT1 STAT2 IRF9 JAK1 IRF-1 PSMB8 IFITM1 IFIT1 PMC2262896__F4 TCR signaling pathway CSK TEC RAC1 CBL ITK FYN LCK CRP NEK2 SHB LAT CRB2 NEK1 PMC8225190__F6 Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response TSC2 TSC1 TFEB PTEN RHEB PMC9113089__F2 Glioma and the gut–brain axis: opportunities and future perspectives CCK PYY IL1B PMC2311292__F2 Pathway representation of all the tryptophan related genes analyzed CARM1 CYP1B1 INS ALDH3A2 MAOA AADAT GCDH CASP3 LCMT2 LCMT1 KYNU PRMT2 GFER OGDH ALDH9A1 PMC7746821__F1 Summary of drug resistance in tumor immunotherapy CD47 PBRM1 ATM TIGIT LAG3 TNF CD24 PMC8110656__F8 I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway BAD GFAP GSK3B BAX PMC7460823__F1 Representation of the metabolites and related pathways involved in the Epithelial-Mesenchymal transition (EMT) process in cancer SNAI1 TLR4 YAP1 TAAR8 FFAR3 SMAD2 MMP9 FFAR2 LATS1 ACSS2 TAAR9 CAD PMC9396337__F9 Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3B signaling HDAC3 GFAP GSK3B IL6 BDNF HDAC1 BAX PMC3523725__F7 PPARG COUNTERACTS LRP1-INDUCED VASCULAR CALCIFICATION BY INHIBITING A WNT5A SIGNALING PATHWAY SOX9 PMC10779188__F1 BRAF signaling pathway and targeted therapies in the BRAF pathway BRAF GRB2 MTOR PMC12130703__F0 TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus CGAS TRIM21 IRF3 PMC9707496__F2 Dysregulation of FBW7 in malignant lymphoproliferative disorders CREBBP EP300 STAT3 PMC8959654__F1 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC PMC8959654__F2 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC PMC8959654__F3 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC DKK1 PMC10341994__F8 Mechanism of AM polarization toward M1 phenotype and early apoptosis induced by rLLB exposure BCL2 IL6 BAX PMC12232702__F5 AKT phosphorylates USP4 USP4 SMAD4 TRAF6 TBR1 TRAF2 RHEB PMC5710802__F1 cGAS-STING pathway senses cytosolic dsDNA IL10 CGAS PQBP1 IRF3 IL6 PMC6562601__F1 De novo pyrimidine and purine synthesis pathways PFAS ADSL UMPS PAICS HEL-S-70p CAD DHODH PMC9569764__F8 Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri MALL PMC2783859__F3A Identification of Actively Translated mRNA Transcripts in a Rat Model of Early Stage Colon Carcinogenesis PRKCE PRKCZ MAPK9 FOSL1 MAPK10 APC GSK3B MYC ARHA FZD1 CCND3 DVL1 PRKCA CEND1 PPP2R5C LDLR hCG_2014051 PRKCH JUN PMC4667861__F1 Signalling pathways and mechanisms regulated by vagal activation TFAM STAT3 PMC6524401__F1 Overexpression of IL-6 and its potential negative consequences on the viral immune response APC IL4 PMC6522855__F2 Complement pathway CD59 C4B_2 CD46 CD55 CR2 C1S C4A PMC5132394__F8 iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration MMP3 WNT3A APC GSK3B WNT5B PMC9076740__F2 Maturation of beta cells: lessons from in vivo and in vitro models ME1 HEL-S-30 MTOR HEL-S-32 MDH2 HEL-S-26 SLC25A12 SLC25A11 GOT2 PC GPD2 ACLY SLC25A1 GPD1 PMC8576424__F2 GIP Receptor in the CNS for the Pathogenesis of Obesity SOCS3 GIPR GIP PMC1779567__F6 Functional dissection of signaling modules in human TReg cells FHIT APC MYC FOXP3 TP53INP1 PIM1 GIG8 TRAF1 STAT4 SATB1 TNFRSF18 MDM2 IL7R TNFRSF10B S100A4 FADD GATA3 PTTG1 PMC9311382__F1 Gut microbiota in sarcopenia and heart failure IGF1R TRIM63 SMAD2 IL1R1 IL6 BNIP3 TNF MTOR PMC6385748__F7 Graphical representation demonstrating the role of PDK4 in obesity-induced MAM formation and skeletal muscle IR PDK4 IRS1 FOXO1 PMC2871659__F1 Overall scheme of key genetic and epigenetic events in colorectal tumorigenesis COX2 BRAF APC BAX PMC4917669__F2 The MyD88-independent pathway TBK1 CD14 TLR4 IRF7 IRAK1 TRAF3 LBP TRAF6 IRF3 MAL PMC4917669__F4 Graphical abstract TLR4 IRF7 IRF3 MYD88 PMC12146001__F2 Introduction and optimization of lanosterol biosynthesis pathway in E LST1 SMO IPP PMC4917669__F1 MyD88-dependent pathway CD14 TLR4 IRAK1 IRAK2 LBP TRAF6 IRAK4 PMC9569207__F8 Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases TLR4 BAX PMC4320499__F6 MM patient 3 profile schematic MAPK8 MAP3K11 MAPK14 BCL2L1 HIF1A NOTCH1 CCND1 CDK4 SP1 RBPJ MAP3K1 AIP BAG3 RCE1 MAP3K12 NR1C1 RHEB CASP3 MAP4K2 TSC2 TSC1 CDKN1A CDK2 PMAIP1 BCL2 MCL1 PMC5278463__F7 Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism TFEB TREX1 IRF3 PMC11247557__F9 Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T‐cell lymphoma via TLR4 signaling pathway NLRP3 TLR4 TRAF1 BIRC3 BCL2 GSDMD PMC8921549__F7 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury KEAP1 RB1 FADD BAX PMC8921549__F3 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 FADD BAX PMC8921549__F4 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 SIRT1 BAX PMC8921549__F5 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury KEAP1 RB1 BAX PMC4276460__F7 HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells FADD STAT3 PMC7322915__F1 Effect of caffeine on Cdc25 regulation in S RAD1 CDS1 WEE1 APC PMC6370048__F2 Downstream effectors and upstream regulatory pathways of RKIP BRAF GSK3B PTEN BACH1 HMGA2 VCAM1 CXCR4 NOTCH1 YY1 EZH2 CDH2 ADRBK1 STAT3 PMC5961473__F7 miRNA–gene interaction network.Notes: miRNAs are shown in pink, genes from Gmagenta are shown in magenta and genes from Ggreen are shown in green ATP2B4 ITGB3 TPM1 AGTR1 sm-M20 CTNNA3 COL5A3 DMD PLN PPP2R2B SCN4B THBS2 HEL-S-273 COL1A2 MYLK PMC2048738__F1 Reactions of the Calvin cycle, starch synthesis, photosynthetic carbon oxygenation pathway, triose-P export, and Suc synthesis represented in the model (Supplemental Appendix S1, A and B) GCA GIP HPR PMC11882405__F10 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action SOCS1 STAT3 BAX PMC2099624__F9 Schematic model of Nrf2 regulation by Keap1 MAF KEAP1 RBX1 PMC9703913__F2 Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma ROCK2 PAK1 ROCK1 TWIST1 VSIG4 TGFBR1 HEL-S-52 TGFBR2 RHO CDC42 PMC3784815__F3 Kidney immune activation against ischemia-reperfusion and transplant injury HEL-S-62p CS APC PMC9371855__F6 Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway HMGB1 RIPK1 GPX4 RIPK3 FADD MLKL PMC4676894__F9 Mechanism-based combinatorial experimental regimens aimed at disrupting known oncogenic cooperation pathways in ABC-DLBCLs RELB MYC IRAK4 PTEN MYD88 BCL6 CARD11 BCL10 BCR BCL2 CD40 SYK JAK1 SMAD1 IRF4 DKFZp781O1323 STAT3 PMC7601443__F3 Crosstalk between adipose tissue clock and important signaling targets KLF15 NAMPT MTOR SIRT1 PMC6314025__F3 Model unifying proteostasis in ER and cytoplasm of Plasmodium falciparum in mechanisms of artemisinin resistance ELF2 PI3 EIF2A PMC4676894__F5 Proposed model for the postulated functions of STAT1 in HR-DLBCL-NOS IL10 STAT1 IL6 JAK1 IFNG PMC4676894__F2 Oncogenic (deregulated) intracellular signaling pathways in germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) CD58 S1PR2 P2RY8 CD2 BCL2 RHO PTEN EZH2 BCL6 PMC7905558__F7 Experimental framework MMP2 LATS1 LATS2 PMC4676894__F3 Oncogenic (deregulated) intracellular signaling pathways in activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) IL10 CD58 IRAK4 IL6 MYD88 CD79B CD79A BCL6 CARD11 BCL10 EP300 BCR CD2 BCL2 CD40 SYK JAK1 IRF4 STAT3 PMC9644577__F2 Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation APC FITM2 PMC2663399__F2 DNA Damage Tolerance: When It’s OK to Make Mistakes PALM RAD18 PCNA PMC5549707__F8 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice TRAF6 MYD88 MAP3K7IP1 TIRAP PMC8068170__F1 WNT signaling pathways APC LRP5 LRP6 ARHA JUN PMC8534197__F8 Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers FLCN PIM2 CASTOR2 EGFR GSK3B MYC TBC1D7 PTEN CSF2RB OSMR IFNG PIM1 GHR MDM2 CASP9 CCND1 FZD7 XB RELN CBY1 STAT2 APC LRP6 IFNAR2 IFNAR1 DEPTOR IRS1 RHEB MLST8 TSC2 TTI1 BIRC2 TSC1 RASSF1 ERBB2 STAT4 GRB2 SLC3A2 FLT3 SESN2 STAT3 PMC2663399__F5 DNA Damage Tolerance: When It’s OK to Make Mistakes ATRIP ATR RAD18 PCNA PMC6623974__F2 Functional interaction network analysis PLAUR VCAM1 PTCH1 SHH CCL2 TRAF2 PMC1360652__F6 Working model for the effects of 15d-PGJ2 and thiazolidinediones on TNF-stimulated NFKB activation and COX2 expression COX2 TNF PPARG PMC4615939__F11 Proposed scheme for mechanical stretch-induced VSMC hypertrophy through leptin synthesis, RhoA/ROCK pathway, ROS formation, and GATA-4 nuclear translocation ARHA RHO GATA4 PMC12205666__F8 SiNPs inducing pulmonary genotoxicity and malignant transformation via autophagy dysfunction RNF168 KEAP1 SQSTM1 MDM2 PMC5378159__F1 Synthesis and metabolism of repressors of SREBP processing and LXR ligands, 24S,25-EC, 25-HC, of the EBI2 ligand 7A,25-diHC and of the RORGt ligand 7B,26-diHC CYP27A1 CH25H CYP46A1 HSD11B1 CYP7B1 CYP7A1 PMC5378159__F3 Synthesis and metabolism of oxysterol modulators of Hh signalling CYP27A1 DHCR7 HSD11B1 CYP7A1 PMC5286373__F2 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype HEL-S-133P PHGDH PMC3771080__F1 Pathway analysis depicting cytokine and cytokine receptor interactions relative to position in the cellular environment IL10 IL1A TGFBR1 IL1RN IFNGR2 IFNAR2 IL6 TNF IFNG IL15 TNFRSF1A IL7R IL15RA TNFRSF10A IL4 TGFB1 PMC5286373__F3 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype PSAT1 PSPH HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC6009840__F1 Metabolic Reprogramming in Kidney Cancer GPX1 ASS1 HEL-S-133P ASL FASN HEL-S-5 GLS PMC2933389__F9 Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications TSC2 TSC1 EIF4E MTOR RHEB PMC6009840__F2 Metabolic Reprogramming in Kidney Cancer DDC MAOA ALDH2 PMC7760867__F1 Relapse-associated genes and pathways interacting with R-CHOP immunochemotherapy BCR ATM MYC MDM2 BCL2 MCL1 ATR CD19 BAX PMC6476918__F1 Canonical and alternative Wnt signaling pathways LEF1 ATF2 APC ARHA LATS1 RAC1 DKK1 JUN LATS2 PMC11701040__F2 Mechanisms by which mitochondrial dysfunction drives the development of chemotolerance in colorectal cancer (CRC): mitochondrial dysfunction drives CRC cell proliferation and chemotolerance BRAF OTUD6A CDC2 ARF1 MTFR2 PMC8264993__F8 AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury ABCA1 AXL PMC10301029__F1 Tyrosine kinase (EGF pathway) and Wnt/Beta-catenin pathways EGF MMP9 EGFR APC LRP5 LRP6 CRK STAT1 COX2 FRS2 GRB2 RND1 STAT3 PMC3640986__F2 Steroid Receptor Coactivator-3 as a Potential Molecular Target for Cancer Therapy IGF1R IGF1 IRS1 IL1B PMC10301029__F2 Overlap between the tyrosine kinase pathway, Wnt/Beta-catenin, and prostaglandin inflammation pathways COX2 FGF2 PMC10301029__F3 EMT transition pathway LEF1 HDAC3 HEL-S-28 SMAD2 ZEB2 GRB2 SHE SRC HDAC2 TNF HDAC1 STAT3 PMC6627503__F2 Mitochondrial antiviral response IRF7 IRF3 MAVS PMC11965601__F1 LBP in inhibiting retinal cell apoptosis LBP MTOR IL1B PMC4339376__F10 Effects of Magnolol and Honokiol on Adhesion, Yeast-Hyphal Transition, and Formation of Biofilm by Candida albicans ECE1 PMC11965601__F3 Flavonoids in inhibiting retinal cell apoptosis NGF BDNF PMC7433927__F1 Interrelationships among components of the 1-carbon metabolism pathway (Methionine cycle, Folate cycle, and Transsulfuration pathway) CTH HEL-S-61p MTR SRM DHFR MTRR TYMS FTCD MTOR SMS PMC8654269__F1 IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies TIFAB IRAK1 TRAF6 MYD88 TIRAP PMC11965601__F6 Autophagy regulation in Lycium barbarum L TSC2 ULK1 LBP ULK2 PMC2678718__F1 Conversion of subendothelial macrophages into cholesterol-laden foam cells is believed to constitute the foundation of the atherosclerotic lesion FYN MARCO LYN CD68 PMC5032153__F1 Notch signalling pathway ECD DLL4 ADAM17 PMC8369418__F1 NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo NNT NMNAT3 SLC22A3 NRK SLC36A4 SLC12A8 NAPRT HAAO SLC25A51 HEL-S-90n NMNAT1 KYNU KMO NMNAT2 AFMID SARM1 PMC5079664__F1 CDK4-CDK6 protect DNMT1 from autophagy PML CDK4 PMC4799531__F1 The central metabolic pathways leading to n-butanol in E HBD PMC5368219__F1 Alterations in histone methylation in pediatric and adult high-grade glioma BRAF EGFR CHTOP PMC9382911__F1 Pyruvate as a Potential Beneficial Anion in Resuscitation Fluids PC PMC11900823__F7 Mechanism of BRD7 inhibiting immune escape of NPC BRD7 MTOR STAT3 PMC9304652__F2 Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin MTOR STAT3 BAX PMC3191034__F7 Postulated model for GRTH negative autocrine molecular mechanism of regulation of androgen synthesis in Leydig cells STAR HMGCR PMC8441359__F2 Chronic low‐grade inflammation in heart failure with preserved ejection fraction NLRP3 IL1R1 TNF IL1B GSDMD PMC8478560__F2 Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer BAD HOXD10 STXBP4 TPD52 PMC4822552__F4 Serum transferrin carrying the xeno-tetrasaccharide NeuAc-Gal-GlcNAc2 is a biomarker of ALG1-CDG RFT1 ALG1 GAL PMC3243745__F6 Metabolic pathways illustrating TCDD-elicited changes in the mouse (A) and rat (B) ALDOB LIPC DGAT2 CHDH AIDA LPIN2 HEL-S-69p HEL-S-162eP PAK1 GPAT2 CHKA PGP LPL GPD2 PMC6193072__F1 Canonical NFKB pathway BCL10 CYLD CXCR4 RELB FOXP3 PMC4622839__F1 PIK3/AKT/mTOR signaling pathway in acute myeloid leukemia RICTOR BAD PTEN EIF4E MTOR MLST8 PMC6348597__F1 The signaling pathway implicated in VIDD development TLR4 SRC MTOR PMC6275407__F2 T helper cell differentiation signaling pathway IL21R STAT4 CXCR5 CD40 CD80 IL23R TGFA IL6R ICOS STAT3 FOXP3 PMC7667157__F7 ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway NOTCH1 PMC4234172__F2 Signaling pathways employed by CSCs: Distinct combinations of paracrine and juxtracrine signals induce the EMT in different contexts FOS SMAD2 LRP5 SMAD4 SMO ROR1 FZD5 STAT3 PMC3892554__F2 TRB3 at the crossroads of ER stress and mTORC function ATF4 EIF2A MTOR PMC9568463__F8 HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress HERC2 ATF2 GPX1 HEL-S-44 PMC5761485__F1 Biosynthetic pathway of steroid sulfates CYP11A1 HSD3B2 CYP17A1 STAR PMC5445662__F1 Intracellular signaling pathways associated with IR-induced cell death modalities CASP3 TSC2 ATM CASP9 RIPK3 PTEN ULK2 MTOR BAX PMC2769199__F8 Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice TLR4 IRF3 MYD88 TLR3 MAL PMC6027703__F5 Relationship between Beta-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway summarized NCOR1 MEN1 PMC7642974__F9 The autophagy pathway by E3 ubiquitin ligases HERC2 ULK1 ATG12 LRSAM1 AMBRA1 TRAF6 HUWE1 ATG101 OPTN FBXW11 DEPTOR DKFZp686F0183 PINK1 TFEB TRIM32 WIPI2 CRBN PMC6120695__F2 Secreted immunomodulatory factors transcriptionally induced by oncogenic Kras signaling CXCL1 CXCL5 CXCL8 CXCL2 PMC5394116__F1 Although a myriad of intracellular signaling is involved in passive therapies, their pathways show some overlap CXCR4 CTLA4 MTOR PMC5761026__F1 Simplified scheme for one-carbon metabolism DHFR MTRR PMC2593475__F1 PI3K/PTEN/Akt/mTOR Pathway BAD PTEN MTOR PMC2674579__F1 GST-MDA-7 causes PERK-dependent vacuolization and JNK pathway activation in transformed cells that leads to cell death BAD BAX PMC4203662__F1 Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment PTEN SGK1 PMC7192953__F6 Interregulation of the PIKK family members DNA-PKcs and ATM and their downstream substrates in the DDR pathway activated following DSB induction by IR PLK1 ATM HIF1A RBX1 H2AX PMC4019000__F1 Dietary Fatty Acids and the Aging Brain TES PDK2 GSK3B ABO GSK3A PTEN BDNF RXRA INSR PMC7192953__F4 Pathways of DNA double-strand break repair POLE BRCA2 RAD51 PARP1 BRCA1 PMC8396177__F1 Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease TLR4 MPO SRC PMC6120695__F3 Cooperation of Kras-mutant tumor cells with pancreatic stellate cells in tumor microenvironment (TME) immunomodulation CXCL10 IL6 CXCL12 STAT3 PMC3765962__F2 Important molecular pathways and drug targets in RCC FLT1 EPO KDR FLT4 VHL MTOR HEL-S-133P HEL-S-68p PMC9434839__F3 Oxidative stress in ovarian aging: a review BAD KEAP1 MTOR NQO1 PMC5381329__F1 Homocysteine metabolic pathway CTH MTR PMC3548977__F1 Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists HHIP IGF2 MYC BCL2 SMO PMC8204050__F7 Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation TSC2 F2 CYC1 INS POC1A SIRT1 RHEB CFTR CD36 PMC9457687__F5 Single cell states of the NFKB signaling pathway CXCL8 IL6 UBB IL1B PMC2235216__F1 Arsenic-induced acquired androgen independence FOS JUN PMC8074247__F6 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer PC STAC ATM APC KLF4 RHO ATR PMC8074247__F4 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer CCR3 APP MAPDA PMC10135714__F10 Schematic illustration shows the protective effect of extract of Lonicera japonica in particulate-matter (PM)2 MYD88 TNF BAX PMC8074247__F8 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer CS NGF ATM CDK2 EMSY POR ATR PDPK1 PMC8783446__F10 Novel Gamma-sarcoglycan interactors in murine muscle membranes BRAF NCL ABHD4 SGCE NR3A2 PURA NACA C12orf57 SPN TMEM50A TRIM25 SGCZ PRDX3 EPB41L4A TACC2 RNPEP DMD DAG1 SGCG HEL-S-80p SGCD ERBB2 PAICS SVIL PMC6274615__F1 KEGG-defined p53 signaling pathway with dysregulated mRNA and miRNA highlighted TSC2 BAD PERP ATM CDK2 MYC MDM2 CASP9 PTEN ATR RFWD2 BAX PMC8465847__F1 Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer RUNX3 CX3CR1 CXCR5 PRF1 LAG3 TOX CD69 PMC6408950__F1 RBP-J functions as a key negative regulator of osteoclastogenesis and inflammatory bone resorption NFATC1 PLCG2 TNF PMC2924379__F2 Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis NAIP BAD TRADD TRAF6 DIABLO HTRA2 CASP3 BIK CASP8 FADD HRK BAX BOK PMC11842356__F2 Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics TBK1 CGAS CXCL10 IRF3 CCL5 TNF PMC8481092__F1 MiR-2392 in driving SARS-CoV-2 infection HEL-S-30 ND2 APP PFKFB4 RHO ND4 PMC2920679__F1 Regulation of mammalian target of rapamycin (mTOR) signaling functions TSC2 TSC1 FBXW7 RHEB PMC5035594__F1 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer EEF2K EEF2 EIF2A PMC5035594__F2 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer EGF HGF NGF BCR SRC PMC2709429__F11 Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin DDC CD36 PMC11880921__F1 Biosynthesis pathway of GD2 (5) UGCG B4GALT5 B4GALNT1 GAL ST8SIA1 B3GALT4 PMC3272624__F1 Schematic depicting mTORC1 signaling in a NAC a medium spiny neuron with anterogradely transported BDNF being released from a VTA dopamine neuron terminal and glutamate released from a prefrontal cortex projection neuron TSC2 TSC1 MTOR BDNF RHEB PMC6352924__F2 Tumour necrosis factor receptor 1 (TNFR1) signalling pathway RIPK1 TRADD TRAF5 CYLD RIPK3 TNF TRAF2 FADD MLKL TAB3 PMC7642974__F1 Action and classification of E3 ubiquitin ligases causing neurological diseases in human HACE1 HERC2 TRAF3 RING1 RANBP2 ASB10 RNF168 RNF170 HEL-S-305 HERC1 FBXO31 ELOC LRSAM1 TRIM2 HECW2 FBXO7 SKP1 HUWE1 FBXL7 RBX1 FBXW11 DDB1 RHOBTB2 RNF125 CUL4B MID1 TRIP12 TRIM32 PEX10 TOPORS UBE3B CRBN ITCH PMC5830185__F2 Current evidence on statin use and prostate cancer prevention: are we there yet? EGF CDK2 RHO MTOR PMC5840201__F1 Neurosteroid synthesis in the retina CYP27A1 CYP46A1 CYP11A1 CYP17A1 CYP21A2 PMC5543040__F1 Gonadotropin-releasing hormone (GnRH) receptor signal transduction in human cancers EGF GNRHR EGFR CCND1 SRC JUND BRCA1 BAX PMC2865534__F1 Heterologous Expression and Maturation of an NADP-Dependent [NiFe]-Hydrogenase: A Key Enzyme in Biofuel Production HPD CP PMC2814769__F5 Primary Cilium as a Complex Signaling Center APC GSK3B LRP5 LRP6 ARHA PMC4148120__F7 MAPK pathway as an apoptosis enhancer in melanoma BRAF SPRED1 PMC5006112__F1 MTOR pathway TSC2 RICTOR TSC1 EGFR STK11 PTEN MTOR PMC5817802__F3 Model for TMPRSS2-ERG regulation of the IGF1R gene IGF1 ERG PMC7525950__F2 PI3K-mTOR autophagy pathway utilizes PIP3 lipid signaling TSC2 ULK1 TSC1 PTEN RHEB PMC7007879__F7 Potential differences between Socs3 and Cish gene expression SOCS3 CISH BRD2 PMC2861325__F9 An Ingenuity pathway analysis containing about half of the genes in subfactor 8 of Myc factor 6 TTK MYC PROX1 GOSR2 UBE2S DKFZp686L0365 GLO1 HEL-S-94n LRRC59 BACH2 TUBA1C HEL-S-44 HNRNPR RAC1 ARF1 CHEK1 AURKA EIF4G1 AURKB HEL-S-69p HEL-S-162eP BUB1B TUBG1 NEK2 HEL164 HEL-S-276 PSMD2 HEL-S-93 RPL7 PSMD11 PMC6387281__F1 Schematic overview of the autophagy process and genetic and drug targets to inhibit specific aspects of autophagy ATG12 ATG3 ULK2 ATG10 DKFZp686F0183 PMC8557683__F6 Circular RNA expression profiles in human bronchial epithelial cells treated with beryllium sulfate BAD IRF9 GRAP PMC1890551__F1 Eumelanin synthesis pathway and gene duplications in vertebrates DCT TYRP1 OCA2 PMC1550314__F1 Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells EGFR GRB2 HBEGF PMC7261339__F1 RhoA/ROCK signalling pathway in PH pathogenesis CDK2 ARHA CDK4 PTEN SMAD1 PMC1890551__F4 Pteridine synthesis pathway and gene duplications in vertebrates SPR PTS XDH GCHFR PMC7935738__F1 Hepatic bile acid metabolism CYP27A1 FGFR4 CYP7A1 PMC5969560__F1 Mitochondrial complex III Rieske Fe-S protein processing and assembly UQCRB UQCRC1 UQCRH FES CYC1 UQCRC2 TTC19 UQCRFS1 PMC3586680__F1 Schematic diagrams of WWOX structure and its role in signaling ERBB4 RUNX2 APC SRC WWOX PMC7325873__F2 Graphical representation of DENV life cycle and subversion of the innate immune response: The virus enters the host cell through receptor mediated endocytosis or antibody dependent enhancement STAT1 TLR4 STAT2 FURIN TLR3 MAVS PMC3235041__F1 SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen SULT1A1 CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP1A2 PMC5653458__F1 Emerging roles for the lysosome in lipid metabolism NPC1 ACAT1 LIPA LDLR NPC2 PMC4403552__F1 Fabric of signaling cascades can be activated by astrocyte Gq-GPCRs MARCKS CSK GSK3B ADRBK1 CDC42 DGKA PMC4658486__F4 Pathophysiology and management of CVD HEL-S-62p VCAM1 C6 PMC4104073__F2 Splicing regulation of the androgen receptor (AR) and phosphoinositide 3-kinase (PI3K) signaling pathways TSC2 TSC1 MYC FKBP5 SND1 PTEN FGFR2 RHEB PMC8448888__F5 Suggested scheme of the SNO-dependent mTOR activation in the ASD and AD mouse models MAPKAPK2 AGTR1 GSK3B TBC1D7 TRAF6 RAC1 DEPTOR RHEB MLST8 TSC2 TSC1 RPS6 FZD10 PMC8231932__F4 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art ATF4 EIF2A BCL2 XBP1 FADD BAX PMC2268988__F3 Life and death decisions by the E2F transcription factors BAD APAF1 TOPBP1 MDM2 SIRT1 BAX PMC8448888__F3 Clustering analysis of the SNOed proteins in ASD and AD mouse models POP4 APBA1 APP GNAS CPLX2 MYLK ADNP PMC10379139__F2 Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms SMAD2 TGFBR1 TGFBR2 SMAD4 TGFBR3 TGFB1 PMC8815029__F1 Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications TRPV4 PIEZO1 ARHA PMC9456274__F1 Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation CER1 CERS3 CERS5 PMC8231932__F2 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art TBK1 TRAF3 IRF3 TYK2 MAVS PMC8231932__F3 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art NLRP3 ATF2 TRAF3 PMC3600733__F2 The quantitative system pharmacology approach for a schizophrenia model is based on actual preclinical neurophysiology and human neuroanatomy KDR HEL-S-11 PMC8191213__F3 Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation SULF1 RUNX2 VSNL1 SMNDC1 LAMC2 PMC6572052__F3 Transforming growth factorB (TGFB) signaling pathway with marked expression levels of deregulated genes BAMBI NODAL PITX2 TGFBR1 SMAD4 SKP1 ARHA TNF LTBP1 IFNG FST SMURF2 SP1 PMC6572052__F4 Hippo Signaling pathway with marked expression levels of deregulated genes GNE AFP PATJ SOX2 GIG8 AMOT AREG APC SCRIB RASSF6 KERA NID1 PMC6281221__F5 Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress BAD FOS GIP ARHA RHO RYR2 NR1C1 VIP SOX9 CFTR HCN4 TIAM1 GHRL PAK1 AMH NPY HEL-S-11 GLI3 RAF1 HCN2 BDNF JUN VAV2 PMC9081902__F2 Processing of dietary lipids for chylomicrons synthesis ARFRP1 APOA4 AIDA DENND5B LPA TG MTTP CD36 PMC6539587__F1 Sequence information of the overexpression vector HIF-1Alpha-pcDNA3.0 NDE1 PMC9006750__F1 Pathway choice in replication-coupled ICL repair NEIL3 FANCM VCP TRAIP PMC6816781__F6 Signaling pathway regarding the cell cycle regulation in human bladder transitional carcinoma/BFTC-905 cells after stimulated by LSS CCNA2 WEE1 CDK2 CCND1 CDK4 CDC2 SMAD1 CDK6 DKFZp781O1323 CCNE1 PMC11822028__F3 Transcriptomic and proteomic profiles of G. subvermispora and T. versicolor of 4-HBA catabolic pathways, TCA cycle, and glyoxylate shunt under different cultivation conditions CS FH PMC7910522__F3 Retinoids in the visual cycle: role of the retinal G protein-coupled receptor LRAT RPE65 RDH8 RDH5 RPE PMC9163413__F8 Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model TLR4 TRAF6 MYD88 IL1B PMC3266783__F2 Basal cell carcinoma — molecular biology and potential new therapies HHIP BOC KIF7 PTCH1 GSK3B SMO GAS1 SPOP PMC2749259__F2 Hypothetical diagram of possible sites of action of non-opioids in the regulatory pathway of IL-6 STAT1 SOCS3 JAK1 STAT3 PMC5500325__F7 Nutritional and reproductive signaling revealed by comparative gene expression analysis in Chrysopa pallens (Rambur) at different nutritional statuses TSC2 BAD HEL-S-11 GRB2 INS MTOR RHEB PMC9047912__F1 Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population IKBKG TRAF6 BCL2 CRK CRKL CBL PMC3693156__F1 Cholesterol synthesis pathway ARHA RAC1 CDC42 PMC3705986__F7 Schematic diagram that describes neuroprotective effects of SUL against ABeta-induced oxidative cell death in AD CS KEAP1 NQO1 BAX PMC11760869__F1 Role of the IHH/PTHrP signaling pathway in regulating chondrocyte hypertrophy IHH RUNX2 PTCH1 SMO PMC6260216__F8 Scheme summarizing the protective effects of miR-27a on LPS-induced acute lung injury via the inhibiting TLR4/MyD88/NFKB activation TLR4 MYD88 IL1B PMC9582513__F3 DNA damage checkpoint execution and the rules of its disengagement ATM BLM TOPBP1 BRCA2 ATRIP MDC1 ATR DNA2 BRCA1 PMC8774043__F7 Extracellular HSP90A Induces MyD88-IRAK Complex-Associated IKKA/B−NFKB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization IL10 TLR4 IRAK1 CD163 SEC22B IRF3 TYK2 IRAK4 MYD88 TNF STAT3 PMC10891274__F2 YAP/TAZ in fibroblast-like synovial cells (FLS) and its related signaling pathway involved in RA TEAD3 TEAD4 TEAD2 PMC11760869__F2 Roles of the WNT, BMP, and TGFB signaling pathways in regulating chondrocyte hypertrophy RUNX2 BMP2 SMAD2 APC LRP5 SMAD4 LRP6 ACAN SMAD1 DKFZp781O1323 SOX9 BMP4 PMC11760869__F3 Roles of the hypoxia, inflammatory (NFKB and VEGF), FGF, YAP, and mTOR signaling pathways in regulating chondrocyte hypertrophy RUNX2 MTOR PMC3360882__F8 Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals CD37 GSK3B PMC5216724__F6 EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway EGR1 EGFR HOXD3 PMC6149728__F1 Schematic model for IL-1 mediated induction of IL-22 in cancer NLRP3 IL16 AHR IL1B PMC6944604__F5 The roles of ADAR2-mediated RNA editing in cancer development IGFBP7 SLC22A3 PMC4085722__F2 Regulation of protein trafficking, receptor signaling, and protein clearance by ubiquitination in Alzheimer's disease APC CCNB1 MDM2 APP FBXO2 FBXW7 PMC6048292__F1 Ferroptosis and its molecular regulation by Nrf2 GPX4 HEL-S-64p PMC10933339__F9 Schematic model of the contributor and potential mechanism of KAL in the occurrence and development of NAFLD ABHD5 KLF4 LRP6 PNPLA2 PMC10891274__F1 YAP/TAZ activity is tightly regulated via Hippo signaling TEAD3 TEAD4 LATS1 MOB1A MOBKL1A LATS2 BPI TEAD2 PMC5142168__F11 Inhibition of HCO3− absorption by HMGB1 in the MTAL HMGB1 ROCK1 RHO PMC6944604__F2 The roles of ADAR1-mediated RNA editing in Multiple myeloma (MM), basal cell carcinoma (BCC) and medulloblastoma (MB) SUFU NEIL1 DYRK1A PMC2171390__F7 Calcium-independent microtubule-dependent pathway is required for FcɛRI-mediated degranulation in mast cells FYN GAB2 LYN ARHA PMC10383295__F2 High levels of ROS promote cancer cell growth, proliferation, invasion, and metastasis SSB PMC10383295__F3 Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells TH BAD TRADD MTOR BRCA1 FADD BAX PMC8000459__F3 GP6 Signaling Pathway in HS line of Japanese quail BTK ARHG LYN RAC1 SCHIP1 LAT GP6 PMC7047328__F2 Tryptophan breakdown via the kynurenine pathway and its interactions with the immune system: This figure illustrates tryptophan breakdown via the kynurenine pathway IDO1 HEL-S-90n AHR KMO IDO2 WAS PMC5322732__F6 Summary and pathway schematic PIK3R1 PBRM1 KEAP1 MAPK3 MYC NRAS MAPK14 USP28 ARID2 SMAD4 RB1 MED23 CDK6 NF1 ACVR2A MAPK1 MAP3K1 CDKN1B SPRED1 HRAS ARID1A RHEB RXRA TSC2 TSC1 CDKN1A MAX GNB1 BRAF MAP2K4 EGFR TGFBR2 PTEN MAP2K3 MTOR PHF6 GADD45B ATM FOXA1 PAWR NF2 KDM5C CIC CCND1 CDK4 CCAR1 JUN MAP6 ZC3H18 DDX3X ARID1B MAP2K1 ERBB2 PIK3CA PMC7539315__F5 Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B LPCAT3 STEAP3 GFAP HEL-S-64p TF CP PMC7796775__F1 Steroidogenesis pathway in 21-hydroxylase deficiency HSD11B2 SULT2A1 CYP11A1 HSD3B2 CYP17A1 CYP21A2 STAR CYP11B2 PMC6700212__F1 Dual sequential cell death checkpoints in the TNFR1 signaling pathway RIPK1 TRADD CYLD RIPK3 TNF TRAF2 FADD MLKL PMC8350018__F3 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway IGF1 NFKB1 GAST PMC9561420__F2 Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response IL10 TBK1 PDC TLR4 TRAF6 IRF3 PMC321431__F10 Cascade of transcription factors that induce stress gene expression in response to eIF2A phosphorylation ATF4 ATF2 ATF3 PMC6507454__F5 Transcriptome analysis results of nuclear factor erythroid-2 related factor 2 knockdown CEBPE ADD1 SUMO2 PPP3CA NEUROG1 CAST STK24 BIRC7 HEL23 GADD45B IL18 PDE10A TREX2 FOSB CNOT3 PICALM EIF4B NMT2 IL1B NCOR2 ZBTB2 PHOX2A OPRD1 ZNF639 DNTT FOSL1 MAFF RBCK1 ADD2 CNP SH3GL1 GOLGA3 NR1C1 PEX14 HNF4A MAFK PSIP1 AAG1 JUND POLR2C HEL-S-93 PXN PMC7761500__F2 Various tumor-promoting mechanisms that can be exploited in combination with immune checkpoint inhibition CXCR1 TWIST1 IL8RB ELL IFNG STAT3 PMC7609165__F1 Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection ESX1 CGAS ATG16L1 TLR4 TFEB TRIM16 IRGM CLEC4E MYD88 MTOR NR1C1 PMC6402819__F5 R-loops drive DNA damage responses ATM ATRIP SSB ATR PMC9511979__F1 Relationships among microbiota, gastric cancer, and immunotherapy GSK3B SHH PMC9511979__F2 Relationships among microbiota, gastric cancer, and immunotherapy GIG8 UBA6 APC GC CTLA4 IFNG PMC7037737__F5 Interactions between the WNT pathway and aerobic glycolysis in exudative AMD APC GSK3B LRP5 LRP6 HEL-S-133P PMC11216096__F2 Wnt signaling in gastric cancer: current progress and future prospects WNT3 RNF43 WNT4 APC WNT1 LRP5 LRP6 ROR2 WNT2B WNT10B ROR1 TCF4 PMC11216096__F1 Wnt signaling in gastric cancer: current progress and future prospects APC UNK ARHA RAC1 PMC9408922__F1 Biochemical Hazards during Three Phases of Assisted Reproductive Technology: Repercussions Associated with Epigenesis and Imprinting DHFR SLC19A1 PMC9696608__F1 Immunotherapeutic Implications of Toll-like Receptors Activation in Tumor Microenvironment TRAF3 IRF3 MYD88 TLR3 PMC2804071__F4 Joubert syndrome: insights into brain development, cilium biology and complex disease ARL13B LEF1 RPGRIP1L PDGFRA BBS4 NPHP1 SHH CC2D2A BBS1 CEP290 RPGR PMC8602690__F2 Mechanism Actions of Astragaloside IV Prevents the Progression of Hypertensive Heart Disease Based on Network Pharmacology and Experimental Pharmacology CHUK MPO RELA VEGFA TNF PMC3585156__F5 Net Expression Inhibits the Growth of Pancreatic Ductal Adenocarcinoma Cell PL45 In Vitro and In Vivo CDK2 CDK4 PMC11119514__F1 RDNVs reverse osteoporosis by potentiating osteogenic differentiation of hBMSCs via targeting estrogen receptor A (ERA) signaling RUNX2 BMP2 SMAD1 DKFZp781O1323 PMC5061806__F2 Targeting mTOR for neurodegenerative disorders TSC2 EGF TSC1 EPO MTOR BDNF SIRT1 PMC8780245__F7 Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCB1 signaling pathway in diabetic atherosclerosis IRAK1 RELA TRAF6 MYD88 TIRAP PMC8496745__F1 How Oncogenic Viruses Exploit p62-Mediated Selective Autophagy for Cancer Development TBK1 RNF168 CGAS ULK1 KEAP1 RAD51 BRCA1 TRIM23 PMC1681476__F1 An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules EGF EGFR GRB2 SHE PMC4139479__F6 A Novel Mechanism of Skin Tumor Promotion Involving Interferon-gamma (IFNG)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling JAK1 IFNGR1 IFNG PMC5819891__F4 Homeostatic Systems, Biocybernetics, and Autonomic Neuroscience NTS REST SPN PMC8151764__F1 Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases IPP HEL-S-5 PMC8591697__F2 Targeting regulatory T cells for immunotherapy in melanoma CD163 CD80 LAG3 PMC2417166__F8 Wnt signaling pathways in INS-1 cells EGF GSK3B TCF7L2 PMC6114982__F8 Palbociclib resistance and MAP kinase pathway inhibition CDK2 CDK4 MTOR CDK7 CDK6 PMC11687129__F8 Mechanism of TAL in PD models TH RARA TRH TRHR DRD2 PMC7606110__F1 Current regulatory model of Wnt/Beta-catenin signaling, and the Wnt-targeting natural compounds which are currently under investigation APC CD44 BCL9 PMC2423294__F8 The PKD1/class II HDAC/MEF2 signaling pathway in skeletal muscle PKD1 PMC8786725__F1 Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms EGR1 CA12 TF PMC8326751__F4 Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report HEL-S-62p C1S PMC5068240__F10 Model illustrating the mode of action of RLTPR in T cells GRAP2 GRB2 PMC9035706__F1 Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling PFAS ADSL SHMT1 PAICS MTHFD1 HEL-S-51e MTHFD2 MTHFD1L PMC11040302__F1 Application of artificial hibernation technology in acute brain injury TLR4 CD163 RBM3 MYD88 PMC8437760__F2 Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019 EGF SOX2 SAG AQP5 MUC5AC HOPX CD34 FOXP2 SOX17 SOX9 FOXA2 PMC5338303__F2 Schemes of kinetic model used as a base for simulation of isotopologue distribution PC CIT MAL PMC9521683__F2 The POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes PLCG1 PDE3B AgRP TRPC5 ARC LEPR FOXO1 INSR STAT3 PMC6462321__F7 General summary of the NBP-involved cellular signal pathway in (a) cancer cell proliferation, migration, and apoptosis and in (b) stem cell differentiation MMP9 BCL2 BAX PMC3227667__F3 Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis MTFMT SHMT1 DHFR MTHFD1 HEL-S-70p HEL-S-51e MTHFD2 AMT MTHFD1L PMC4700477__F10 Selected potential Rho GTPase functional networks identified in the RNAi screen ROCK2 CDC42BPB ARHGEF7 ARHA RHO RAC1 NCK1 ECT2 CYFIP2 ARHGAP5 CYFIP1 DOCK9 TRIO DOCK7 CDC42 PMC6121505__F2 Inhibition of apoptosis mediated by mFas and TRAIL EGF PI3 FADD PMC6121505__F3 Role of TLR3, 7 and 9 in SS TBK1 EGF TLR7 TLR9 IRF7 TRAF6 IRF3 MYD88 FADD TLR3 PMC10610100__F2 Protein–protein interaction (PPI) network map of the KEGG enriched signal pathway of differential genes HHIP NR5A1 GUCY1A2 FOS KPG_010 RGS2 NR1C1 VIP RGS14 GPX3 LCP2 PDE10A NPY PMC6691693__F2 Differentially expressed genes involved in cell cycle pathway E2F4 ORC6 SMAD4 DBF4 ORC3 CDK7 CDC45 CDK6 ORC2 CDC20 SMC3 CDK2 MDM2 CDK4 PCNA SKP2 MYT1 PMC5351557__F2 Yeast mitogen-activated protein kinase signaling pathway, illustrating the signaling paths in responses to different signals GLO1 FAR1 PMC6859786__F1 NLR-dependent regulation of MHC class I antigen presentation NLRP3 NOD1 B2M IL1B NOD2 PMC11877141__F0 Battling pain from osteoarthritis: causing novel cell death ADORA2B CGAS GPX4 TRADD KEAP1 PIEZO1 MYC NOX4 MYD88 MTOR NQO1 GSDMD NLRP3 RIPK1 SFRP1 TRPA1 STEAP3 FOS RIPK3 HEL-S-64p NACA2 ADAM10 TXNIP TRAF2 FADD SIRT1 MLKL TF DFNA5 PMC9705310__F8 Schematic diagram of the proposed divergent effects of astrocyte-specific Cp knockout on learning and memory function HP TF CP BAX PMC11956203__F4 Key mechanisms of neuro-cancer crosstalk in HNC MMP7 COX2 MMP2 GALR2 CXCR4 MMP9 IL6 ABCG2 S100A4 GAD1 GLA PMC7085407__F3 PGC-1A signaling pathway in response to ROS/RNS SCO2 PTEN TFAM SIRT3 PMC6682711__F2 Autophagy signaling in HCC TSC2 ULK1 TSC1 PTEN RHEB PMC8711784__F2 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion TBK1 CGAS IRF3 PMC2887331__F2 Serine/threonine kinase Akt, also known as protein kinase B (PKB), has become a major focus of attention because of its critical regulatory role in diverse cellular processes, including cancer progression BAD PTEN HIF1A MTOR PMC7155254__F4 ERS and oxidative stress in patients with NAFLD and the generation and crosstalk of ROS signalling connecting these pathways APAF1 ATF4 BCL2 TRAF2 XBP1 IRS1 CYP2E1 PMC8711784__F1 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion TBK1 STAT1 CGAS STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC6929077__F1 Nicotinamide (NAM) and Nicotinamide Adenine Dinucleotide (NAD+) metabolism NAPRT NAMPT HEL-S-90n NADK NNMT NRK PMC2921957__F4 Summary of factor H recognition functions and interactions TH FH CRP PMC11854763__F2 Signaling pathways directly and indirectly linked to RhoA/ROCK-mediated activation of GSK3B and the positive feedback loop between AB deposition and GSK3B activation BACE1 ROCK2 ROCK1 APP SRC LRP6 ARHA PTEN PMC8666288__F2 Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis ATF4 UNK MTOR DKFZp762B153 PMC7906326__F3 Current understanding of the interplays between host hormones and plant viral infections AGO1 CP PMC9200435__F3 Metabolic reprogramming in pancreatic adenocarcinoma (PDAC) SLC7A5 ME1 LDLR SOAT1 ACLY HMGCR PMC2857099__F6 Proposed model for NFKB repression by TRAF3 in LTBR activation TRAF3 TRAF2 LTBR PMC6002979__F1 B cell receptor signaling pathway BTK CARD11 BCL10 BCR BASH LYN TRAF6 CD40 SYK MTOR CD19 PMC3281723__F2 Role of PHLPP in terminating oncogenic signaling pathways PTEN MTOR PMC6002979__F2 Canonical and non-canonical NFKB signaling pathways LTA TLR4 RELB TRAF6 MTOR PMC8971810__F4 C1q/Tumor Necrosis Factor-Related Protein 9: Basics and Therapeutic Potentials CD14 TLR4 TRAF6 MYD88 CDH2 GATA4 IFNG STAT3 PMC3807240__F1 The NLRP3 inflammasome regulates the DNA damage response pathway BIRC3 OGG1 PMC3161973__F1 Putative mogrosides biosynthesis pathway in Siraitia grosvenorii CS MVD PMC7712090__F2 Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment CSNK2A1 FOS IL6 HRAS IL6R MAP2K1 PTPN11 GRB2 IL6ST RAF1 JAK1 SOS1 JUN STAT3 PMC7500866__F1 Somatic Liver Knockout (SLiK): A quick and efficient way of generating liver-specific knockout mice using multiplex CRISPR/Cas9 gene editing HPDL HPD SLK PMC3003974__F3 Protein interaction network of highly connected proteins associated with the cardiorenal syndrome PIK3CD EGF CYBA PRKCE FOS EGFR MAPK14 INS NCF4 CEBPB EDNRA EDNRB RELA SRC IL6ST ATR ACE2 PPARG EPHB2 NCF2 PMC4695871__F2 Binding of the Hedgehog ligand (SHH) to Patched (PTCH1) removes the inhibitory signal for the G-protein-coupled receptor, Smoothened (SMO), causing translocation of the GLI1 and GLI2 transcription factors into the nucleus PTCH1 SHH SMO PMC8016706__F2 Growth and stress signalling pathways dictate responsiveness to stimuli and are hijacked in skin malignancy EGF EGFR RELB MYC TNLG7C HES1 EDAR COX2 WNT4 RELA TIMP3 MDM2 CCND1 BCL2 BAX PMC7415804__F1 Canonical Type I IFN signaling activated by DNA virus and RNA virus TBK1 CGAS TLR9 STAT2 IRAK1 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 IFNG STAT1 TLR7 TRAF5 TYK2 JAK1 TRAF2 TIRAP MAVS PMC9108753__F10 scEFSC: Accurate single-cell RNA-seq data analysis via ensemble consensus clustering based on multiple feature selections ROCK2 TH BAMBI ECD CBY1 GDA APC SOST SKP1 RYK IL25 POR NLK HEL-S-11 TOX C13orf34 LAT PMC7415804__F2 Mechanisms of actions of lncRNAs in regulating innate antiviral response TBK1 CGAS GPR55 STAT2 SFPQ IRF3 IFNAR2 IFNAR1 TRIM25 TLR3 STAT1 TYK2 MAVS PMC5725130__F3 Identification of hub genes related to silicone-induced immune response in rats HEL-S-62p CD14 CS CTSK TLR9 APC IL6 RAC1 BCR LBP CD40 KEL FADD TIRAP PMC10232107__F2 Compound-gene targets-signaling pathway network of the eight phytochemicals related to neuroinflammation CASP3 SRC TNF PPARG PMC5768609__F1 Schematic diagram depicting the role of miR-27a in Mycobacterium avium subspecies paratuberculosis (MAP)-mediated signaling pathways in macrophage TLR4 TES TLR1 MAP3K7IP1 IL1B PMC2910789__F1 Selected IGF-axis genes that encode core components of IGF-axis upstream the PI3K/AKT/mTOR and RAS/MAPK/ERK pathway IRS4 IGF1R IGF1 IGFBP1 IGF2 MTOR IGFBP5 IRS1 PMC8050094__F6 Intracellular Ca2+ cycling HEL-S-11 LPA PMC6940904__F1 Overview of the complement cascade and principal complement targeting molecules HEL-S-62p CD59 C9 C4B_2 MBP FH C7 C6 CR1 PMC8868096__F2 Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia KEAP1 SFN HMOX1 NQO1 PMC3347452__F7 Proposed model of SubAB-induced PERK-mediated apoptosis signaling pathway in HeLa cells ATF4 EIF2A BAX PMC3380363__F1 Oncogenic signaling pathways regulated by NO and PP2A EGFR SRC PMC3703147__F1 Ubiquitination-mediated regulation of interferon responses STAT1 STAT2 PMC7752511__F1 Oxidative Stress, Nutrition and Cancer: Friends or Foes? FGF21 BMP2 MSC CD34 FGF10 BMP4 CD24 PMC8846937__F1 Pathophysiology of stress granules: An emerging link to diseases (Review) TIA1 FUS PMC7549330__F7 Diagram illustrating the molecular mechanism of LINC01315 in proliferation, invasion, and migration of OSCC cells PMC6588869__F1 Monolignol and ethylene biosynthesis pathways CAD JCAD PMC7560080__F3 ROS and low-molecular-weight hyaluronic acid (LMWHA) involvement in both priming and activation of the NLRP3 inflammasome NLRP3 CD44 MYD88 PMC8621356__F3 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach TSC2 TSC1 PDK2 PTEN EIF4E MTOR IRS1 RHEB PMC8621356__F2 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach TSC2 BAD TSC1 PTEN MTOR FOXO1 PMC10815772__F1 FGF/FGFR and downstream signaling pathway FRS2 GRB2 MTOR PMC10815772__F2 Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers KIT RET FRS2 GRB2 FGFR3 MTOR PMC5990418__F3A Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV BAD PTEN FOXO1 PMC4347898__F5 Phosphortlated Smad3 is stabilized by ERG in prostate cells ERG SMAD2 PMC7581496__F8 FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential YAP1 MYC GRB2 LATS1 FGF18 RHO LATS2 FGFR2 CDC42 PMC1236692__F3 Caspase signaling and its modulation GAS2 PMC12116916__F8 TLR4 signaling modes and outcomes TBK1 RIPK1 TLR4 SYK PLCG2 MYD88 MAL PMC8044766__F1 Thrombotic and thrombolytic cascades and primordial immune response A2M PLG VWF SERP1 PMC7260648__F1 Mechanisms underlying cytoplasmic organellar dysfunction after chemotherapy and melatonin's protective effects under these conditions IL1B SIRT3 PMC6319725__F9 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells NAMPT SMAD1 FADD PMC6319725__F8 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells NAMPT HIRA MYBBP1A ADA SIK3 FGF18 SP1 FADD PMC7539774__F6 Schematic diagram of HP-based regulation in breast cancer glycolytic signaling pathway HEL-S-30 PFKP HEL-S-133P PMC10751872__F3 Advances in Regulating Cellular Behavior Using Micropatterns BMP2 LATS1 LATS2 PMC3824073__F2 Outline of the Crosstalk between p53 Family Members and the mTORC1 Pathwayp53 and p63 act upstream of mTORC1 and inhibit mTORC1 activity via multiple transcriptional targets TSC2 PLK2 TSC1 IGF1 PTEN RHEB PMC9266763__F2 Revisiting Regulated Cell Death Responses in Viral Infections NLRP3 HMGB1 RIPK1 IL18 CYLD TRAF3 RIPK3 TRAF2 GSDMD PMC9266763__F4 Revisiting Regulated Cell Death Responses in Viral Infections MMP25 TRADD STAT2 NLRP1 PRG3 RIPK3 GSDMD CRP LBP TYK2 JAK1 ACE2 FADD MLKL TMPRSS2 BAX PMC4991322__F1 The conserved pathway of sterol synthesis, storage and transformation in C ATF2 DIO1 ENO1 IDI1 PMC9289199__F2 Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones IGF1 PRLR LDLR CRTC2 FSHR HMGCR PMC3891587__F2 GENETIC CONTROL OF CANDIDA ALBICANS BIOFILM DEVELOPMENT GHB3 PES1 NUP85 NRG1 ADH5 ACE2 ECE1 PMC2999593__F1 Heme Biosynthetic Pathway UROD UROS CPO PMC6192719__F5 Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches SULF2 MICU1 APLN DMTN HDAC11 STC1 SERPINB8 TNF SLC16A3 NRP2 UTP18 G0S2 LAP3 SEC22B APOL6 BCL2 FBXO31 MAPK1 SLC6A8 MME PMC8004672__F7 Correlation between growth factor signaling, the actin cytoskeleton, and CCN2 expression in CHs IGF1 RAC1 TGFA CTGF PMC3766629__F6 Immunohistochemical Staining, Laser Capture Microdissection and FASP Assisted Proteomic Analysis of Target Cell Populations within Tissue Samples PIG59 LIPC C4B_2 PLEC NUP62 PIGR MUC5B RDX COL1A1 CLU HEL-S-108 HSPG2 RAP1A HEL-S-273 ATP2A2 HEL114 TRAM2 CALD1 CDC42 PMC3823507__F1 Post-translational regulation of iron homeostasis HAMP STEAP3 SMAD4 HFE PMC5527460__F1 KRAS‐dependent genetic network analysis MMD NAB1 UBXN7 TPM3 ELP2 BASP1 VPS28 MPHOSPH10 DHPS RPS16 RAD18 BRCA1 VMP1 ORC2 NKD1 FEN1 BNC1 HEL-S-49 UBC ATM RAD51 ELF4 DENR PHB2 PMC4075245__F1 Simplified schema showing how genes might affect clinical responses to targeted therapies CCR6 STAT4 TRAF1 CD244 CD40 IL6ST CTLA4 TNF BLK PADI4 PTPN22 PMC4657846__F6 Sites of complement pathway dysregulation HEL-S-62p CFH CFI PMC3899800__F2 BRCA1 and its toolbox for the maintenance of genome integrity RNF168 RNF8 H2AX PMC3899800__F3 BRCA1 and its toolbox for the maintenance of genome integrity FANCD2 RAD51 PMC10531820__F6 Regulatory T Cells in Cancer Treatment Resistance PTEN MTOR PMC6901085__F1 Representation of AKT pathway and downstream effectors BAD PRR5 PTEN EIF4E MTOR IRS1 RHEB MLST8 TSC2 RICTOR TSC1 GAB2 MDM2 GRB2 CCND1 BAX PMC8833603__F4 Protein Disulfide Isomerase in Breast Cancer ATF4 EIF2A PMC2577137__F1 Cross talk between PKA, PI3K/AKT and WNT/CTNNB1 intracellular signaling pathways IGF1R IGF1 FSHR PTEN MTOR FOXO1 PMC7843555__F1 Five domains of T-cell dysfunction BTLA YY1 CD80 CTLA4 TIGIT LAG3 PMC2776679__F7 Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R EGR1 HIPK2 IGF1R IGF1 PTEN PMC4657846__F1 Normal complement cascade HEL-S-62p C9 C7 C6 C1S PMC4816186__F6 Notch 1 signaling pathway and proposed mechanism of action of CJ NFKB2 MYC ADAM10 ERO1A BAX PMC9267699__F2 New Avenues of Heme Synthesis Regulation TH FECH UROD UROS HMBS CPOX PMC4657846__F2 Normal regulation of the complement AP HEL-S-62p CFH CFI PMC4463661__F1 Biochemistry of hydrogen production in Synechocystis PCC 6803 by direct biophotolysis TH PC SI CYB PMC5392381__F2 Central BCR signaling network constructed from literature BTK CARD11 BCL10 BCR BASH LYN SYK PLCG2 PTEN CD19 PMC6473547__F5 Vitamins on Alzheimer’s disease CDK5 ADAM10 PMC6989314__F4 Pathway mechanism of the cell cycle CDK2 SMC3 CDK7 PCNA SKP2 MYT1 PMC7057654__F2 Vaccinations can inhibit the release of various pro-tumor cytokines WT1 ARF6 PMC2600644__F4 Pathway schematic of significantly regulated genes in (A) NFKB signalling and (B) MAP kinase signalling ADORA2B NFKBIL1 TRADD MAPK3 MAPK14 TRAF3 TRAF6 MAP2K6 MAP4K1 TICAM1 TNFRSF9 JUN FOS ADRB2 TRAIP TLR1 MAP3K12 HEL-S-31 EDARADD MAP4K2 NFKBIA DUSP5 MAPK6 TRAF5 MAP3K2 NFKB1 TNFRSF8 TRAF1 TNFRSF1A MAP3K14 MBIP MAP3K8 TRAF3IP2 TNFRSF10B TNFRSF10A TNFAIP3 DUSP8 TRAF4 NFKBIE CDC42 PMC3328839__F6 Proposed pathway EIF4E MTOR ORAI1 TF STIM1 PMC7827439__F3 Cytokine-mediated immune–epithelial crosstalk in inflammatory bowel diseases TH APC IL33 TNF OSM PMC5737637__F6 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism ME1 HEL-S-26 SLC25A11 NNT ME3 SLC25A1 PMC7327232__F4 Membrane receptors on parietal and enterochromaffin-like (ECL) cells and intracellular signaling pathways that regulate gastric acid secretion EGF CASR EGFR TGFA PMC5357762__F1 Canonical and non-canonical Wnt signaling ZNRF3 DAAM1 CDK14 APC ARHA RNF4 JUN FBXW7 PMC5737637__F2 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism NAPRT NAMPT HEL-S-90n NADK NRK PMC5357762__F2 Mutation rates of Wnt pathway components in selected cancer entities RNF43 APC GSK3B AXIN1 LRP6 TCF7L2 GPR49 FBXW7 PMC4910040__F1 mTOR signaling pathway TSC2 EEF2K TSC1 EEF2 RHO EIF4E RHEB PMC6251962__F1 Innate immunity and adaptive immunity TLR9 IL33 CXCL8 IL25 TSLP PMC3943178__F3 Coordination of macrophage-mediated signaling and muscle regeneration SMAD2 KLF4 TNF IFNG PMC11016796__F2 Proteomic analyses on chicken breast meat with white striping myopathy PINK1 PARK2 CDKN1A MDM2 BAG2 PMC5868586__F7 Schematic illustration of the underlying mechanism of L61H46’s anticancer activity.Abbreviations: IFN, interferon; IL, interleukin STAT1 STAT2 JAK1 STAT3 PMC3188673__F5 Vitamin D Metabolism and Function in the Skin APC GSK3B CCND1 DKK1 PMC8761221__F1 Autophagy regulatory pathways TSC2 ULK1 TSC1 IL3 ULK2 MTOR PMC2919366__F4 STAT3 signaling pathway SOCS3 IFNG STAT3 PMC4224557__F8 Postulated molecular regulation of eukaryotic elongation factor-2 kinase (eEF-2K)/TG2 pathway to the invasion-promoting signalling in pancreatic cancer (PaCa) cells SRC PMC4600531__F1 Wnt Signaling in Bone and Muscle APC ARHA RAC1 PMC8422159__F12 Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NFKB Pathway TLR4 MYD88 TNF PMC5234110__F7 Schematic representation of the suggested dynamic effects of PGE2 on naïve and primed microglia COX2 TLR4 TNF PMC8141399__F1 Banxia Xiexin Decoction Inhibits the Expression of PD-L1 Through Multi-Target and Multi-Pathway Regulation of Major Oncogenes in Gastric Cancer EGF EGFR TRAF6 PTEN MYD88 MTOR TIRAP IFNG PMC11616203__F3 Effect of TRPM channels on signal pathways related to tumor progression CDK2 EGFR MDM2 TRPM2 PTEN HIF1A MTOR TRPM1 TRPM7 PCNA CCNE1 TRPM8 PMC2171731__F9 Invadopodium formation EGF CDC42 NCK1 PMC8242249__F6 Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFNB Production by Inducing Ubiquitination of RIG-I TBK1 TRAF3 IRF3 TRIM25 MAVS RNF125 PMC7696523__F1 Canonical Hedgehog signaling in Basal Cell Carcinoma PTCH2 SUFU SMO PMC12206634__F10 The diverse intestinal innate immune pathway responses induced by non-S INDEL and S INDEL PEDV strain in weaned (A) and suckling (B) piglets NLRP3 ISG15 ADAR IRF7 TRAF3 TRIM25 TRAF2 MAVS MX2 MX1 PMC7963165__F1 Upstream mediators of TXNIP signaling NLRP3 TLR4 TXNIP PTEN ATF5 MYD88 TXN GSDMD PMC5522257__F3 Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer DNM3 VAV1 GSK3B RAC1 PMC7757414__F1 Targeted therapies available and in development in Acute Myeloid Leukemia (AML) KIT CD33 IRAK1 TEC IRAK4 MTOR HEL-S-26 BCOR CXCR4 BCL2 SMO EZH2 FLT3 CDK9 PMC8224798__F2 Harnessing the Physiological Functions of Cellular Prion Protein in the Kidneys: Applications for Treating Renal Diseases ARHA MTOR TF PMC5355992__F9 Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo TLR4 TRAF6 MYD88 PMC8472231__F7 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells PML IFIT2 CYBA F2R HLA-DQB1 CCL2 IL12A SP100 OSMR MX1 ISG15 GBP1 OAS1 OAS2 XAF1 TLR4 opn GHR IRF-1 CD14 ANXA1 SDC1 IRF7 FOS BST2 CD44 NCAM1 TWIST1 LYN EPHA2 PYCARD PMC8472231__F8 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells VASP BAD HEL-S-28 GRB2 SHE RHO PTEN CRK CDC42 PMC8472231__F9 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells CASP3 MMP3 TRADD TRAF3 TNF TRAF2 MME FADD NOD2 ITCH PMC2920345__F3 Viral tricks to grid-lock the type I interferon system STAT1 FEV STAT2 IRF9 INS TYK2 JAK1 PMC1312313__F8 NO• regulation of the cell cycle CDC20 CDC6 CDK2 CDK4 CDC2 CDC25B CDK6 PMC8472231__F6 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells CD14 IRF7 FOS CD44 HLA-DQB1 HLA-DRB1 CD74 KRT18 HLA-DPB1 FGFR1 HLA-DQA1 BIRC3 LYN GHR EPHA2 IRF-1 PMC12049846__F7 Mechanisms CTSK ROCK1 NFATC1 DCSTAMP ARHA ACP5 MAGI1 PMC5446554__F1 Highly simplified overview of various functions of the mitochondrion, adjusted to highlight the steps catalyzed by enzymes for which the respective encoding genes were studied in this work OGDH GCSH PMC5384497__F1 Schematic view of the anti-inflammatory roles of SLPI in obesity-related atherosclerosis pathway TLR4 CSA2 SLPI PMC6661007__F2 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases BRAF VEGFA CCND1 HIF1A ORAI1 STIM1 PMC6661007__F3 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases NLRP3 CXCL1 CXCL10 CXCL12 STAT3 PMC8617635__F9 Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine CCR7 UNK CD40 CD69 PMC9170998__F3 Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review APAF1 CDK4 PMC4496240__F7 Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways BMP2 CDK2 SMAD4 GADD45A SMAD1 DKFZp781O1323 BAX PMC11969448__F1 miRNA-dependent resistance mechanisms to anti-hormonal therapies in estrogen receptor-positive breast cancer patients CDK2 APC EGFR GSK3B BCL2 CDK4 PTEN CDC2 MTOR TF CDK6 PMC12027374__F2 LH on spermatogenesis, LCs, and sperm cells EGFR CYP11A1 FSHR HSD17B3 CYP17A1 PMC12027374__F3 LH regulates testosterone synthesis in LCs through multiple pathways FOXO3A EGFR STAR PMC2291030__F3 EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software PLCG1 EGF GRB2 STAT3 PMC4919564__F1 Regulation of AMPK by metabolic stress, LKB1, and intracellular Ca++ TSC2 NRF1 MTOR HMGCR PMC6850886__F12 How PPM1H counteracts LRRK2 signaling pathway by dephosphorylating Rab proteins RAB35 VPS35 LRRK2 RAB43 PPM1H RAB10 VPS29 RAB7L1 PMC7407194__F1 Autophagic Machinery ULK1 ATG16L1 ATG12 ATG3 AMBRA1 ATG101 UVRAG DKFZp686F0183 PMC7407194__F2 DSB repair NHEJ1 RIF1 ATM BLM BRCA2 RAD51 H2AX RBBP8 PMC4919564__F2 Representative signaling in the AMPK pathway by various AMPK activators ADIPOR1 ADIPOR2 MTOR SIRT1 PMC7407194__F3 Main pathways regulating the DDR-mediated autophagic response TSC2 ULK1 AATF ATM AMBRA1 PARP1 ATG101 PTEN UVRAG DEPTOR DDIT4 RB1CC1 PMC9116923__F3 Autophagy and Renal Fibrosis TSC2 ULK1 TSC1 ATG12 GABARAPL1 BCL2 BNIP3L ULK2 GAL BNIP3 TNF MTOR PMC3276397__F1 Effects of VitA in gut-associated lymphoid tissue RARA FOXP3 PMC10887144__F1 In vitro liver organoid model creation EGF FGF4 HGF STH OSM BMP4 PMC10648512__F3 Effect of exosomes derived from glioma stem cells and containing miR-26a on the BBB GSC PTEN MTOR PMC4410569__F7 HJV and HFE Play Distinct Roles in Regulating Hepcidin HFE TFR2 PMC9662265__F1 Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion MSC S1PR1 TXNIP SOX6 PMC3688919__F8 microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model HES3 SMAD2 APC LRP5 SMAD4 LRP6 PTEN MTOR COL1A1 WNT3 CDKN1A RECK SHH SMO STAT3 PMC7555132__F3 Cdc48-dependent MAD and mitochondrial quality control mechanisms PINK1 MFN2 HUWE1 UBR1 NDE1 PMC12162925__F7 Integrating transcriptomics and metabolomics data IMPACT APOC1 TG HMGCR PMC9675748__F6 Consequences of HDAC6 activity inhibition regulation through TubA treatment in DMD mice model MTOR PMC8383741__F7 IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway CXCR3 LIMK1 CXCR4 CDC42 PMC6881211__F9 Emerging roles of the long non-coding RNA 01296/microRNA-143-3p/MSI2 axis in development of thyroid cancer CCND1 STAT3 MSI2 PMC6514059__F2 Expression of the NCRs and their Ligands IL15 IL2 CFP PCNA NID1 PMC7467481__F1 Balance between thrombosis and bleeding in liver disease TFPI PLG ADAMTS13 PMC7175458__F4 Classic AHR signaling pathway AHRR AHR PAH PMC3356574__F3 The signaling pathways regulating radiation-induced bystander effects through expression and secretion of soluble biologically active factors COX2 LEF1 IGF1R IGF1 ATM IL33 IL6 TNF STAT3 PMC9333350__SF1 TLR9 signaling pathways TLR9 IRF7 IRAK1 UNC93B1 TRAF6 IRAK4 MYD88 PMC8065911__F7 Schematic diagram showing the effects of ABZ on STAT3/5 signaling pathway via modulating SHP-1 expression CCND1 SRC JAK1 STAT3 PMC5217513__F1 AXL structure and effector pathways.Notes: Shown are the primary structural determinants impacting AXL activation and signaling SRC AXL PMC8276817__F2 Molecular targets for FAK inhibitor combination therapy ARHA LATS1 PMC3539509__F2 TLR4 signaling pathway: TLR4 is localized on cell surface for ligand recognition and activates both MyD88-dependent pathway and TRIF-dependent pathway TBK1 TLR4 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 MAL PMC2423434__F5 Dynamically asserted instances of interactions DDI2 DDI1 CYP3A4 APC PMC7309610__F2 Innate immune pattern recognition of bacterial lipids on OMVs leads to inflammation and death NLRP3 CD14 TLR4 LBP IRF3 MYD88 IL1B TIRAP PMC7296058__F4 G6PD in cancers BAG3 KEAP1 PAK4 PTEN ID1 PMC10975841__F4 Dietary Factors on DNA Methylation Levels of TNF-Alpha Gene and Proteome Profiles in Obese Men TSC2 BAD CD37 MEI1 BCR MDM2 PTEN RAC1 EIF4E RBL2 RHEB CD19 PMC7296058__F1 Pentose phosphate pathway (PPP) HEL107 RPE PMC3436816__F2 EnrichNet: network-based gene set enrichment analysis LRRK2 EGFR APC TPR SCRIB PTEN RB1 IL22RA2 MINPP1 RET FLT1 TSC1 AHR BCR NF2 MSH6 IL22 PPP2CA CR2 IL20 OSM PMC7532093__F8 Protein-protein interaction network of hsa-miR-30a-5p-related DEGs EYA2 CFL2 DMD OVOL2 MAF FYN FZD2 CELF2 HLF CCNE2 NCAM1 RAB3D SLC30A2 SIX4 TET2 FER PRSS21 EDNRA E2F7 LONRF1 RNF26 PITPNM2 RECK DCP2 CHKA CPEB4 PHACTR2 BCL2 GLDC HEL113 JAK1 RORA PMC11855089__F8 Comprehensive analysis of metabolomics and network pharmacology H1-6 HIST1H1E CYP2C9 H1-3 H1-2 IMPACT H1-5 PMC7532093__F9 Protein-protein interaction network EREG SSH2 MTA2 SMC1A MSL2 NMNAT2 HEL114 FKBP4 HEL-S-133P POLI VPS35 STX6 CKS2 TP63 YKT6 CASP3 RFC1 IXL SEC22C FER KMT2A FMN1 MLLT3 SEC22A CXCL12 APH1B PLAG1 PMC156764__F1 NEW EMBO MEMBER’S REVIEW TRADD RELA CCND1 TRAF6 MYD88 TNF FADD PMC7367602__F1 Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide PLN KL PLP2 TRHDE HSF1 GRAP AATK PMC7464161__F8 Possible mechanism of action of metformin and everolimus in QGP-1 and H727 cells TSC2 AIP TSC1 IGF1 MTOR IRS1 PMC7869416__F6 Schematic diagram illustrating Eif2s3y functions in goat SSCs NR1B3 GDNF PMC6358305__F1 Schematic biochemical pathway for the production of bioactive chemical mediators leukotriene C4 (LTC4) and leukotriene B4 (LTB4) LTA LTB PMC6358305__F2 Incorporation of arachidonic acid into membrane-bound phospholipids by the Lands pathway () DGAT1 COX2 COX1 ACAT1 DGAT2 TES ACAT2 PMC6837928__F1 Folate metabolism and interaction with other nutrients such as vitamin B12 and choline HEL-S-61p DHFR PMC4506441__F5 Distribution of target proteins on the compressed ‘influenza-related pathway’ REN UCP1 EGFR GSK3B PLCG2 MIP PIM1 COX2 CTSA CHRM2 NOS2 PLG IRF3 IL6 TRIM25 TLR3 PLN CPA3 CHRM3 CDK2 CD40 NLN LNPEP MME ELL STAT3 PMC7788045__F6 Schematic illustrating the Sirt1–FGF21 axis and vilda-mediated cardiac protection FGF21 DPP4 SIRT1 PMC314316__F1 Schematic model indicating the presence of two potential insulin receptor–dependent signal transduction pathways VAMP2 APC SNAP23 PMC7316884__F1 De novo ceramide synthesis pathway and its hormonal regulators in adipose tissue TLR4 CERS3 LASS1 CERS5 TNF KDSR CERS2 CERS6 PMC4860032__F1 The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer SRD5A2 CYP17A1 PMC3824660__F2 Interrelations between autophagy-related signaling and cell growth control in response to stress TSC2 TSC1 ATF4 EIF2A PTEN BNIP3 MTOR IRS1 RHEB PMC7796305__F3 Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy SMAD2 SMAD4 ACE2 PMC7796305__F2 Complex network of interplayed cellular and molecular mechanisms that participle in the development of myocardial fibrosis leading to the occurrence of dystrophin-deficient cardiomyopathy PI3 SMAD4 PMC6274739__F2 Basic TGFB signaling diagram along with a program of TGFBeta-regulated genes that contribute to the EMT TWIST1 ZEB2 TRAF6 ARHA RHO CDH2 SMURF1 HAS2 TRAF4 ESRP2 ESRP1 PMC5917448__F12 1-Deoxynojirimycin on gastric ulcer by affecting NFKB pathway COX2 COX1 TNF PMC3608642__F4 Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity POR TOX PMC8622657__F3 Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration GRB2 CBL PMC6023839__F5 Regulatory Network and Crosstalk Analysis for Gene Set(A) KEGG pathway network formed by relapse gene sets CEBPE PPP3CA MYC MEIS1 EZR NRIP3 WT1 SOX4 DEPDC1 ZEB2 PIGA OPA1 PRKAB1 NOTCH2 INHBC NAIP APC ATF3 CCL4 PTPN13 LMNA DEPTOR SDC2 PLCB4 HMGA2 MYBL1 DUSP10 HEL-S-308 SMURF2 TGIF1 MED13 PBX3 ADCY9 MPO TBL1X ACTN1 YBX3 NOD2 HCAR3 ORC2 HSDL2 OAS2 AHR AGA JUP MED13L CPOX CXADR SCARB2 JUN KAT2B PLCL2 DNTT PURA CXCL2 PEX3 SMURF1 AURKA BET1 CACYBP ITGAM SMC3 EVI1 LYN GNAS SCML2 GRB10 BNIP3 MSANTD2 MME PMC3549334__F7 Ras activation by •NO-mediated processes in pancreatic cancer RALA RALB HRAS PMC5559481__F1 LncRNAs serve as p53 regulators and effectors, participating in the p53 regulatory pathway PMC4855107__F1 Arachidonic acid (AA) metabolism involved in the pathogenic mechanisms of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity LTA COX1 LTB PMC6581604__F7 LMNA mechanosensing based on a ‘lose it or use it’ mechanism for tension-inhibited turnover that also applies to collagen-I MMP2 LMNA PMC9030951__F1 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy ATF4 APC EIF2A TXNIP XBP1 BAX PMC4629125__F1 Intrahepatic interplays among hepatocytes, non-parenchymal cells (NPC) and lymphocytes and illustration of antiviral and immunotherapeutic strategies TBK1 IRF9 ATF2 IFNGR2 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 IFNG TYK2 JAK1 IFNGR1 TIRAP PMC5659737__F1 Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells LEF1 APC PTCH1 SHH SMO ARHA TGFB1 TF CYP11B2 PMC4833509__F7 Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa TXNIP RPE PMC5828779__F5 Toll-like receptor signaling pathways in the prefrontal cortex TBK1 CD14 IRF7 IRAK1 CXCL10 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR7 TLR4 PMC6581604__F1 Contractility or collagen perturbations result in rapid ~1h changes in LMNA, DNA damage, and cell cycle TH CTRL LMNA H2AX PMC7769821__F4 KEGG pathway schematic diagram of inflammatory bowel disease (IBD) IL3 APC LIF IL4 PMC9030951__F3 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy APC XBP1 SIRT1 PMC7769821__F5 KEGG pathway schematic diagram of cytokine-cytokine receptor interaction SLA LEP LIF PRL PMC3031466__F10 A PtdIns(3)P-mediated signaling pathway that drives the degradation of apoptotic cells SNX6 VPS29 SNX1 PMC3383846__F2 Signaling pathways that regulate cytokine AREs post-transcriptionally IL16 TLR4 HEL-S-76p IL6 PMC5629024__F3 Gene networks with the genes in core from GSEA analysis ZBED3 CCR2 DACH1 PHLDA1 MAP2K2 AHNAK TOP2A KRT18 TSHR BACH2 CCR10 APP USP44 MICAL2 ANGPTL7 IL18R1 PLAG1 TSPAN4 PMC4003375__F1 Nck proteins as the newly identified adaptors between the BCR complex and BCAP/PI3K/Akt pathway BTK BAD LYN GRB2 SYK FOXO1 CD19 PMC8278735__F6 Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NFKB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation TLR4 HEL-S-67p KEAP1 IL6 MYD88 IL1B PMC3648215__F1 Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis LEF1 ARHA PMC8395114__F6 Clavibacter michiganensis Downregulates Photosynthesis and Modifies Monolignols Metabolism Revealing a Crosstalk with Tomato Immune Responses RPS2 MAPK7 PMC3641677__F4 Mechanisms that Regulate Stem Cell Aging and Life Span TSC2 TSC1 IGF1R IGF1 PTEN EIF4E RHEB PMC8787342__F1 Activated Macrophage – A Tough Fortress for Virus Invasion: How Viruses Strike Back CGAS TLR9 IRF7 CXCL8 IRF3 IL6 CCL2 MYD88 TNF TRIM29 TLR3 TLR7 TLR4 CD80 MAVS PMC3500850__F4 Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response HEL-75 HEL-S-133P GLRX HK2 PMC9306048__F7 Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/Beta-catenin signaling pathway to regulate colorectal cancer progression MMP7 APC CDH2 PMC3679382__F8 Working model of the FGF21 regulatory pathway under leucine deprivation FGF21 UCP1 ATF4 EIF2A PMC4040351__F2 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling NOTCH2 NOTCH4 JAG2 GSK3B MYC DLL3 NOTCH3 FBXW7 HES1 DLL4 CCR7 NOTCH1 CCND1 BCL2 PMC4040351__F4 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling GSK3B PTEN MTOR HES1 PMC7143722__F3 De-novo fatty acid synthesis in oleaginous microorganisms (adapted from [,,,,,]), and enzymes involved in lipid accumulation FADS2 PTH LPA HEL-S-5 PMC5133788__F10 11-epi-SA-induced apoptotic pathway in HA22T cancer cells BAD ATF4 EIF2A TRAF2 JUN BAX PMC10037167__F1 Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway NOX4 MSTN PMC8088836__F4 PH Regulation in the Tumor Microenvironment (TME) LDHD FOXM1 VHL HIF1A MTOR PMC3139433__F4 Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes ZSCAN12 RABAC1 HDAC3 MYC SMAD4 RB1 UBE2V1 FGFR2 FYN POMC KDR GRIN1 UGT1A10 SRC TRIO FOS BSN MAP3K7 VEGFA TNF HRAS IRS1 RXRA P2RY2 CDKN1A CDKL5 MAX PPM1F GRB2 MAPK11 TF SUMO1 BRAF GAS1 CHN1 YEATS4 ZMIZ1 NRP2 POLR3D TEF PRKDC YY2 JUN HOXB7 POLR3B FGF2 CHEK1 DDIT3 ERBB2 LCK SERINC3 RAF1 ACIN1 PMC5647233__F4 Hypothetical roles of ANTXR1 as a modulator of HbF expression HBE1 HBD HBG2 HBG1 HBB PMC8636224__F1 Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics TSG101 CD9 CD63 EGFR ARF6 CD81 PMC3206202__F10 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice GAL GAA ELL PMC8870287__F2 Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity BAD IGF1R IGF1 MTOR PMC8036595__F7 Mg2+ and Gd3+ interfere with phosphate-induced SOCE upregulation by the activation of CaSR in megakaryocytes—a schematic representation CASR NFAT5 ORAI1 SGK1 STIM1 PMC11640972__F2 Tryptophan metabolic pathways HEL-S-90n KYNU KMO PMC4361250__F4 Hedgehog signaling in prostate epithelial-mesenchymal growth regulation SUFU PTCH1 GLI3 SMO PMC10451954__F1 Primary Coenzyme Q10 Deficiency: An Update COQ8A COQ4 COQ3 COQ10B COQ2 COQ10A COQ9 COQ6 COQ5 PDSS1 COQ7 COQ8B PMC8220142__F4 Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers IGF1R IGF1 ATM GHR TRIM29 BAX PMC2951628__F1 Inflammation Joins the “Niche” TLR4 S100A8 S100A9 PMC7101072__F1 Research Priorities for Heart Failure with Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary NPPA NPPB PMC8895466__F1 Cell-based immunotherapy of glioblastoma multiforme CSF1R CXCR4 CSF1 PMC3874419__F1 Signaling cross-talk at the various levels of EGFR/HER2 signaling pathways EGFR MDM2 MAPK1 PTEN MTOR PMC8082181__F10 Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway SIRT3 PMC10722483__F6 Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse MTOR TRPV1 PMC4443744__F5 Crosstalk between complement and TLR pathways TLR4 IL6 MYD88 TF PMC3512410__F2 Scheme depicting the different outcomes caused by the presence of progerin and prelamin in cells RBBP4 ATM RUNX2 ATR PMC9509045__F5 Bioinformatic identification of differentially expressed genes associated with hepatocellular carcinoma prognosis CD14 E2F4 PLK1 SMAD2 GSK3B SMAD4 DBF4 ORC3 CDC45 ORC2 CDC6 SMC3 CDK2 MDM2 ORC1L PCNA SKP2 MYT1 PMC10534805__F9 Lonicera Caerulea Juice Alleviates Alcoholic Liver Disease by Regulating Intestinal Flora and the FXR-FGF15 Signaling Pathway MUC4 MUC2 TG NR1C1 CYP7A1 PMC9262551__F3 Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets NLRP3 TXNIP MTOR PMC8268744__F1 Structural and Drug Targeting Insights on Mutant p53 TIGAR PML DDR1 SCO2 SFN BIRC5 AIFM1 GPX1 BCL2L1 ATM APAF1 CCNB1 DRAM1 MDM2 CDC2 MSH2 BAX VEGFA GLS2 XPC GADD45A DDB2 CDKN1A SLC2A4 CXCR4 BCL2 ATR PMC4533861__F7 CX3CL1-induced breast carcinogenesis in ErbB2 transgenic mice CX3CR1 CX3CL1 HBEGF PMC11019510__F5 Role and mechanism of TXNDC5 in disease progression PMC4325379__F1 An overview of melanocyte development KIT DCT TYRP1 SOX10 PMC9131939__F14 Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach ATM PTEN HIF1A ATR RHEB STAT3 BAX PMC6030854__F1 The effects of the Insulin-like Growth Factor 1 (IGF-1) on muscle growth and homeostasis IGF1R IGF1 DEPTOR PMC7991804__F2 An overview of mechanisms of GC resistance in ALL and pharmacological strategies to overcome it CRLF2 GC NR3C1 BCL2 PTEN FLT3 MTOR SGK1 HES1 PMC8115323__F1 WNK-SPAK-NCC pathway and WNK ubiquitination by the CUL3-KLHL3 E3 ubiquitin ligase complex KLHL3 WNK1 OSR1 WNK4 PMC3881016__F5 Pathway analysis of iron deficiency associated chlorosis GIG8 IDI2 COMP PMC8032689__F10 The MAF-TGFB1-crystallin axis that underlies the pathological growth of lens in high myopia MAF SMAD2 SMAD4 PMC6472122__F5 Transfer RNA-derived fragment target genes in the Kyoto Encyclopedia of Genes and Genomes AMPK pathway map generated using DAVID software TSC2 TSC1 HNF4A IGF1 F2 PDK2 INS MTOR RHEB CFTR INSR CD36 PMC8825743__F3 Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review) MTOR EPHA2 LTBR PMC3208056__F4 Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/Beta-catenin/cyclin D1 signaling pathway in rats COX2 APC BCL2 PMC8351444__F7 MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies BCR MAX MYC SRC SYK ELF4 PMC3959161__F2 Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity DGAT1 PCK1 GC LPL TG PMC3255319__F1 Oncogenic and tumor suppressor control of metabolism PRM2 VHL PTEN MTOR PHGDH HEL-S-26 NF1 AGER FH ACLY HEL-S-133P HK2 FASN PMC3260854__F6 FosB-mediated regulation of ECM genes by mechanical signaling in bladder smooth muscle TNC FOSB JUN PMC5870354__F2 SignalingEpithelial growth factor receptor signal transduction STAT1 PLCG1 EGF EGFR GRB2 JAK1 MTOR STAT3 PMC6213175__F3 Select HCMV gene products that target apoptotic pathways during HCMV infection MTOR FADD BAX PMC4028977__F1 Targeting inflammation: multiple innovative ways to reduce prostaglandin E2 COX1 PMC2674743__F2 Altered insulin signaling by lipid intermediates MTOR PMC9100777__F1 Bilayer Forming Phospholipids as Targets for Cancer Therapy PTDSS1 PC SELENOI PCYT2 PISD PTDSS2 PEMT PMC4340906__F5 Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine STAT1 UBC IDO1 AHR NFKB2 SLC7A11 NFKB1 EZH2 COMMD1 JUN TYROBP PMC8204302__F7 Host determinants of disease severity in acute cystitis; mechanism of IL-1B and SP hyperactivation NLRP3 MMP7 TLR4 C6 MYD88 IL1B TIRAP PMC4622840__F1 c-Met-mediated oncogenic signaling (from Peruzzi et al) HGF IMPACT GRB2 PMC6093675__F6 Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling AMOTL2 GSK3B DPYSL5 CTNNBIP1 PMC8508740__F1 New Fast Acting Glucagon for Recovery from Hypoglycemia, a Life-Threatening Situation: Nasal Powder and Injected Stable Solutions PYGB PIGA PMC6236198__F6 Cell cycle pathway (the chart is from the KEGG database, gene symbolized by ★ and correlation P values can be found in ) CDC20 CDK2 SMC3 SMAD2 MDM2 SMAD4 CDK7 CDC45 PCNA ORC2 SKP2 MYT1 PMC3412962__F4 A, Differential expression of proteins involved in glycolysis and TCA cycle PLAA LDHD HEL-S-133P DLAT HEL-S-281 PMC9282876__F7 Sanguinarine Regulates Tumor-Associated Macrophages to Prevent Lung Cancer Angiogenesis Through the WNT/Beta-Catenin Pathway APC WNT7A WNT1 LRP5 LRP6 WNT10B WNT7B PMC8622894__F2 Plasma Ceramides Pathophysiology, Measurements, Challenges, and Opportunities CERT1 SMPD2 DES SMPD1 CERK SMS PMC1069556__F6 Effect of NS5A on the Beta-catenin signaling pathway BAD GSK3B TEF PMC8081964__F3 MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma NUMB IGF1R CD44 LFNG PARP1 RB1 HES1 CDKN1A NFKB1 ERBB2 NOTCH1 CCND1 SMO PMC4097927__F4 Polyamidoamine dendrimer-based gene delivery vectors HEL-S-62p CS NHS C1S DCC PMC7689704__F8 Pipoxolan suppresses the inflammatory factors of NF‐KB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7 murine macrophage cells STAT1 CD14 TLR4 FOS LBP MYD88 JAK1 TIRAP STAT3 PMC4019579__F8 NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages LIMK2 NAMPT TLR4 ARHA RHO CDC42 PMC3667651__F3 Mechanisms underlying molecularly targeted therapeutics-induced cardiac toxicity SRC NRG1 PMC7407594__F2 RNA sensing mechanisms RNASEL TLR8 OAS1 TLR7 RNASET2 RNASE2 IRF3 MYD88 TLR3 IFIT1 PMC7407594__F4 Posttranscriptional mechanisms by RNA-binding proteins (RBPs) regulating mRNA stability N4BP1 EDC4 CARD11 TLR4 BCL10 DCP2 ARID5A PMC6108877__F7 Schematic representation of the anti-invasive effects of wogonin in LPS-stimulated MDA-MB-231 cells, via the 5-LO/BLT2 pathway TLR4 LTB MYD88 PMC6329798__F1 ABPs used for caspase analysis CASP9 BCL2 CASP10 CASP8 PMC7142844__F8 Molecular mechanisms of SNRPG-mediated p53 targeting of TMZ-induced glioblastoma multiforme (GBM) growth inhibition CDK2 CCNB1 SNRPG PMC2881215__F1 Signaling in podocyte apoptosis NOTCH1 GDNF CD2AP PMC7920062__F1 Bile acid metabolism CYP27A1 CYP46A1 CYP7A1 PMC7757049__F3 miR-340 is associated with various genes modulating cancer cell proliferation FHL2 CDK4 JAK1 GPR49 CCNG2 SKP2 BMP4 PMC6030169__F1 Intracellular exposure to intermediate ROS levels triggers conformational changes in KEAP1 via oxidation of its C-terminal cysteines, resulting in dissociation of the KEAP1-NRF2 complex and subsequent nuclear translocation of NRF2 MAX KEAP1 AIFM1 PGAM5 PMC7757049__F4 miR-340 is involved in the regulation of cancer cell apoptosis SOCS3 BAG3 STAT3 PMC5788694__F4 Role of ginsenosides in reactive oxygen species-mediated anticancer therapy NR3A2 ATG3 CYBB MTOR NCF1 DKFZp686F0183 PMC7139912__F2 Symplified representation of pro-inflammatory mediators in Wobbler (Wr) mouse spinal cord NLRP3 HMGB1 IL18 IL16 TLR4 MYD88 PMC5010532__F1 Adaptive UPR in Parkinson׳s disease ATF4 EIF2A BDNF XBP1 PMC10622988__F4 Tumor-associated signaling pathways influenced by lncRNA SOX21-AS1 in breast cancer, lung adenocarcinoma, and glioma WWC1 NF2 TSPAN8 CCND1 LATS2 PMC8996999__F1 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment SLC5A8 FOXO3A TSHR TIMP3 VEGFA TPO HIF1A TGFB1 PMC8996999__F2 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment FOXO3A GSK3B PTEN MTOR PMC6715251__F9 Adenovirus early region 3 RIDA protein limits NFKB signaling through stress-activated EGF receptors PIN1 EGFR RILP PMC7432451__F1 ITAM- and ITIM-signaling receptors sense the microenvironment and determine the response of microglia NLRP3 SIRPA SRC IL1B SIRPB1 TYROBP PMC7818015__F4 DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy RNF113A ALKBH3 RAD51C PMC4427577__F1 Signaling by TGFB family members through the Smad-dependent and Smad-independent pathways: TGFB induces its response by multimerization of TGFB receptor II (TBRII) and TGFB receptor I (TBRI) SMAD4 MAP3K7IP1 PMC6821048__F7 Inhibitory effects of butein on cell proliferation and TNF-Alpha-induced CCL2 release in racially different triple negative breast cancer cells CASP3 IKBKE TRADD CASP10 TRAF2 CASP8 FADD PMC5473901__F8 Summary Effect of miR34a BCL2 PMC4803799__F3 mTOR in sensing autophagy signals : mTOR inhibition integrates amino acid starvation, growth factor deprivation, decreased ATP or oxygen levels, enhanced reactive oxygen species (ROS) to activate autophagy TSC2 ULK1 TSC1 TFEB BNIP3 HIF1A RHEB PMC4443744__F2 Role of complement in physiology CTSL FH IL33 MTOR CR1 HEL-S-162eP PMC4803799__F7 Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches MFN1 USP15 BAG4 CHDH FBXO7 AMBRA1 FUNDC1 TRAF6 TOMM7 USP30 SMURF1 PINK1 BNIP3 SARM1 PARL FIS1 PMC8464934__F2 Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification CD2 GGCT PMC3776718__F3 Overlay of the insulin-like growth factor-1 (IGF-1) signaling pathway with microarray data for comparison of very small embryonic-like stem cells (VSELs) with hematopoietic stem cells (HSCs) BAD IGF1R SOCS3 IGF1 GRB2 NEDD4 STAT3 PMC7545020__F2 An aberrant STAT pathway is central to COVID-19 STAT1 STAT2 IRF9 TYK2 JAK1 PMC7545020__F3 An aberrant STAT pathway is central to COVID-19 EGF SOCS3 EGFR PIAS1 SRC TYK2 JAK1 STAT3 PMC7545020__F4 An aberrant STAT pathway is central to COVID-19 STAT1 TLR4 CRP HAS2 STAT3 PMC5300050__F3 Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly SYK RPS6 CD36 PMC7770133__F2 Summary of reverse MHC-I signaling pathways in various cell types BAD TRAF6 ARHA MYD88 MTOR MMP2 LCK ZAP70 SRC TYK2 SKI REL B2M IL1B STAT3 PMC8869911__F4 Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence GSK3B CCND1 SMO PMC9454566__F9 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response SLA CMKLR1 IRF7 IRF9 BST2 CCRL2 POGZ IFITM1 MX1 ISG15 OAS1 OAS2 OAS3 SAMD9 PMC8968815__F1 Wnt/Beta-catenin signaling pathway related microRNAs in esophageal cancer ZNRF3 SFRP4 DKK3 CDK2 GSK3B DACT3 DKK2 STAT3 PMC7765095__F2 KEGG GO pathways of selected apple Full-length cDNA OvereXpressing (FOX) Arabidopsis mutant lines CRY1 ELF3 CRYZ PMC3829661__F2 Schematic overview ofP PC PSD PMC9454566__F7 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response OAS1 CTBP2 OAS3 BST2 EPSTI1 TFAP2A SAMD9 BCL2L11 IL12RB1 IFIT1 PMC9454566__F8 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response OAS1 USP12 CGAS OAS3 IRF9 BST2 EPSTI1 SAMD9 IFIT1 CLASP2 PMC4528065__F7 Model of CC-122 costimulation of T cells and tumoricidal activity through degradation of Aiolos and Ikaros IRF7 IL2 DDB1 CRBN PMC4672198__F2 MITF function in the nucleus of a melanosome to activate melanin synthesis and secretion and melanocyte growth and survival KIT EDNRB KITLG MC1R SOX10 PAX3 PMC6162501__F2 P53-ARF-MDM2/4 pathway (adapted from the p53 website) PML CDKN1A DKFZp781B1423 MDM2 XPC ERCC5 GADD45A BTG2 BAX PMC11881760__F3 Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease NLRP3 CGAS TLR4 IRF3 MYD88 AIM2 STAT3 PMC6790574__F5 Inflammasome NLRP3 NAIP LTA NLRC4 NLRP1 NLRP6 AIM2 FADD GSDMD PMC6790574__F3 Nucleic acid sensors TBK1 CGAS IRF3 PMC6790574__F1 TLR‐mediated signaling pathway IL10 TBK1 TLR9 IRAK2 TRAF3 IRAK4 IRF3 MYD88 TLR3 IFNG TLR8 TLR7 TLR4 IL4 PMC4985489__F2 Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment HOMER2 MTOR BDNF PMC3151103__F9 Schematic summary of a signaling pathway underlying IL-1Beta-induced dedifferentiation of primary cultured articular chondrocytes NAMPT IL16 SIRT1 SOX9 PMC6234654__F9 Diagrammatic representation of occurrence of colorectal cancer (a) and various modulatory mechanisms of combinatorial administration of probiotics and celecoxib (b) in CRC with respect to different biomarkers APC GSK3B IL1B BAX PMC1905729__F1 Binding of IL-12 to the IL-12RB1 and B2 chains induces phosphorylation of the kinases Tyk2 and Jak2, which associate with the cytoplasmic tails of the B1 and B2 chains, respectively TYK2 IL12RB1 PMC2876151__F7 Cdk1 modulates the activity of several DNA damage checkpoint proteins MRC1 RFC2 CDC20 CDC2 MRE11A DNA2 RFC3 RFC4 PMC8725472__F8 SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFB/PI3K/AKT/GSK3B pathway SCUBE3 CDK2 TGFBR1 CCNE1 PMC4431663__F1 Physiological regulation and pharmacological inhibition of the STAT3 signalling pathway SOCS3 SYK TF STAT3 PMC8201651__F1 Wnt/Beta-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities ZNRF3 RNF43 LRP5 LRP6 GPR49 PMC6321330__F1 Simplified representation showing the interplay between the major signaling cascades activated by tyrosine kinase receptors (RTKs) and TSH-Receptor (TSH-R) DDR1 TSHR MTOR PMC11474142__F3 Major signaling pathways associated with ENPP1 CGAS HP BCL2 BAX PMC8207832__F2 Ubiquitin-dependent protein assembly at DSBs and their roles in DSB repair pathway choice PALB2 RIF1 KEAP1 MDC1 L3MBTL2 UHRF1 USP11 BRCA1 RNF8 ATM BRCA2 RAD51 RFWD3 DNA2 PMC9336077__F2 Molecular biology and therapeutic potential of Nrf2 in leukemia KEAP1 GSK3B SKP1 RBX1 ROR1 BACH1 PMC8511501__F1 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway CXCR1 CCR2 AIP PDE5A MBP CXCL10 MAPK3 IL8RB CCL2 CXCR3 FER MAP2K1 AHR PTPN1 RELA PTPN11 PMC6770560__F9 Coelonin inhibiting LPS-stimulated activation of NFKB and inducing G1 phase cell-cycle arrest in RAW264.7 cells TLR4 TRAF6 PTEN MYD88 PMC3679471__F6 MSP-RON signaling pathway CCR2 TLR4 CCL2 IFNG PMC12103590__F8 Proposed model of hnRNPL phase separation promoting glycolysis in ovarian cancer HNRNPL PFKFB2 PMC3309874__F1 Insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) is a major candidate pathway in human longevity IGF1R IGF1 INS IRS1 INSR PMC8106283__F1 Preventive Role of Cannabinoids Derivate against Methylphenidate-Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration BAD KEAP1 IL1B BAX PMC6215878__F6 Diminished inhibin B (INHBB) expression activates the transforming growth factor‐B (TGF‐B) pathway to promote anoikis resistance and migration SMAD2 SMAD4 INHBB PMC4923650__F1 Integration of RDGN with TGFB to regulate EMT HMGA2 EYA2 SMAD2 ZEB2 TGFBR1 DACH1 SIX1 SMAD1 DKFZp781O1323 PMC3915289__F1 The kynurenine metabolic pathway HAAO KYNU KMO IL1B PMC7391499__F5 Lignin biosynthesis pathway and monolignol biosynthesis related gene expression in P DAP CAD PMC9684248__F7 Pyroptosis in inflammation-related respiratory disease IL6 GSDMC GSDMD STAT3 DFNA5 PMC9684248__F8 Pyroptosis in inflammation-related respiratory disease NLRP3 TXNIP AIM2 PMC3510826__F8 Important roles of SFKs in G protein-coupled receptor-induced platelet activation ARHA PMC5337359__F1 Interactions between the canonical Wnt/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in colon cancer APC LRP5 CCND1 LRP6 HEL-S-133P CPD PMC9684248__F1 Pyroptosis in inflammation-related respiratory disease NLRP3 CD14 HMGB1 IL18 TXNIP MYD88 GSDMD PMC9684248__F2 Pyroptosis in inflammation-related respiratory disease GSDMA GSDMC GSDMB GSDMD DFNA5 PMC3202104__F2 EBV infection impacts on cell death and survival pathways in GC B cells BCR SMAD2 BIK SMAD4 CD40 FADD BAX PMC9684248__F5 Pyroptosis in inflammation-related respiratory disease NLRP3 TLR4 AIM2 GSDMD DFNA5 PMC9684248__F6 Pyroptosis in inflammation-related respiratory disease NLRP3 TLR4 NLRP1 GSDMD PMC9684248__F3 Pyroptosis in inflammation-related respiratory disease NLRP3 TLR4 PFAS AIM2 IL1B GSDMB GSDMD PMC9684248__F4 Pyroptosis in inflammation-related respiratory disease NLRP3 CS TXNIP GSDMD PMC7921316__F3 Molecular mechanisms of natural polyphenols in colon cancer COX2 IL1B FADD PMC10534731__F2 Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review NOX4 MYD88 HIF1A PMC8511501__F6 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway MAP2K1 NFKB2 PTPN1 GRB2 PTPN11 PMC12110172__F1 Hippo-YAP pathway LATS1 LATS2 PMC12157585__F1 C. elegans fatty acid synthesis pathway and FAT-2 desaturase FAT2 FAT1 FAT3 GLA FAT4 PMC8570281__F1 Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis GGH DHFR TYMS HEL-S-70p FPGS SLC19A1 PMC8343371__F1 Coronavirus disease-2019: A review on the disease exacerbation via cytokine storm and concurrent management ACE2 ADAM17 TMPRSS2 PMC8318774__F12 Huotan Jiedu Tongluo Decoction Inhibits Balloon-Injury-Induced Carotid Artery Intimal Hyperplasia in the Rat through the PERK-eIF2Alpha-ATF4 Pathway and Autophagy Mediation ATG12 ATF4 PMC3969039__F2 Putative model of the mechanism of vascular homeostasis mediated by apelin-APJ signaling FGFR1 FGF2 KLF2 PAH PMC8732267__F1 Signaling pathways regulated by GA12/13 in solid tumors GSK3B LATS1 RHO LPA JAK1 LATS2 CDC42 STAT3 PMC4180627__F1 The endocrinology of vitamin D FGF23 CASR NR1i1 DBP CYP24A1 PTH PMC3103347__F5 Effect of SCGB3A2 on TGFB signaling pathway BAMBI EGF RUNX2 SMAD2 TGFBR2 BMP4 IFNG FST NOG opn SKI TGFBR3 GAL JUN RUNX3 SKIL FOS LIF ENG TNF CREBBP SMAD1 DKFZp781O1323 INHBA STAT3 FOXH1 PMC10750283__F4 Nuclear Receptors in the Pathogenesis and Treatment of Non-alcoholic Fatty Liver Disease DGAT2 LPIN1 FGF19 FGFR4 NR1C1 CYP7A1 PMC2623309__F1 Multiple feedback loops of p53 pathway SIAH1 CDK2 CCNG1 MDM2 MAPK14 PTEN PMC7422534__F4 MicroRNA-target interaction networks F2R HEL2 HEL-S-1 CRKL FGF9 TAOK2 FGF23 PPP2R2D DUSP4 FOS FGF2 TAOK3 FGFR3 ITGB1 GNG12 CACNA1I CASP3 NTF3 VEGFC RASSF1 CACNG2 IL3 GRB2 PPP2R5B HEL-S-93 SHC1 RGL2 PMC2874322__F4 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 EPO NLRC4 TLR9 IL13RA1 NLRP12 RB1 BMF NOD2 NLRP3 TAP2 CCL17 APP PSMB9 IRF2 BOLA1 CCL3 PMC2874322__F5 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 CD14 CLDN1 SPRR3 DEFB1 IVL SPRR2E TSLP SPRR2F NOD2 SPRR2G SPRR2B SPRR1A NOD1 SPRR2A FLG IRF2 SPRR1B PMC8615888__F1 STING Signaling and Skin Cancers CGAS SOX2 NLRX1 IRF3 PMC8341640__F2 Critical Role of PARPs in Regulating Innate Immune Responses TBK1 AHR IRF7 IRF3 AKT3 PMC4433321__F8 Hypothetical involvement of glucokinase (GK) and therefore glucokinase activators (GKAs) in the preservation and growth promotion of pancreatic Beta-cells PDX1 BAD PMC8341640__F3 Critical Role of PARPs in Regulating Innate Immune Responses HMGB1 PARP12 PARP10 PARP1 MYD88 PMC10999489__F2 Personalized treatment concepts in extraocular cancer SUFU SMO PMC3725690__F6 Working model for the NOX dependence of TNFA production by the liver following I/R injury RAC1 PMC11212700__F1 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders TBK1 PINK1 ARIH1 FUNDC1 SRC BNIP3L MUL1 BNIP3 PGAM5 OPTN PHB2 PMC11212700__F2 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders NLRP3 PINK1 MFN2 ULK1 GGT7 TLR9 BNIP3L GNAS BNIP3 GPR176 SIRT1 PMC8341640__F1 Critical Role of PARPs in Regulating Innate Immune Responses TBK1 CGAS SSB PARP2 PARP1 IRF3 PARP3 PMC4174596__F1 Hh pathway response in vertebrates PORCN SMO PMC4918286__F1 Hippo pathway signaling in Drosophila and mammals.Note: (A) Signaling diagram FRMD1 RUNX2 BIRC5 NF2 AREG APP TBX5 AJUBA RASSF6 PAX3 LATS2 PMC6110482__F6 Exposure to nicotine-derived nitrosamine ketone and arecoline synergistically facilitates tumor aggressiveness via overexpression of epidermal growth factor receptor and its downstream signaling in head and neck squamous cell carcinoma EGFR BAX PMC7756113__F3 Mechanism of autophagy SQSTM1 MTOR DKFZp686F0183 PMC6637043__F9 Schematic diagram showing the proposed signalling pathways for inflammatory and autoimmunity‐associated gene expression via Ca2+ and Ca2+‐dependent/‐binding proteins ERBB2 CAST FGF10 CD40 LEPR MYD88 CSA2 TNF NFATC3 STAT3 PMC9599458__F3 Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities NOX4 IL6 MTOR PMC6563119__F1 Canonical and alternative Hippo pathways FOXO3A TEAD4 IRF3 RAP2C LATS1 MOB1A MOBKL1A HEL-S-31 FOXO1 RAP2A LATS2 MAP4K1 TEAD2 MAP4K2 TEAD3 RAP2B MAP4K3 F3 PMC4226164__F1 Damage-associated molecular pattern signaling mechanisms NLRP3 MYD88 IL1B CDC42 PMC3103347__F7 Schematic diagram for the SCGB3A2-induced inhibition of the TGFB signaling pathway STAT1 SCGB3A2 SMAD2 IFNG PMC5836099__F5 Mitotic arrest and slippage in inflammation and immunity CGAS CDC20 OMP PIDD1 IRF3 BAX PMC6563119__F5 Dual functions of the cancer cell-intrinsic Hippo pathway in immune modulation TEAD3 CXCL1 CXCL5 TEAD4 CXCL2 LATS1 CCL2 CSF1 LATS2 IRF-1 TEAD2 PMC3670510__F1 Targetable metabolic actors by natural compounds GCG HK2 HEL-S-162eP PMC5357299__F8 Schematic overview of the proposed iOGN:TLR4 signaling pathway TLR4 TRAF6 MYD88 TIRAP PMC6563119__F4 Roles of the Hippo pathway in effector T cell differentiation APC IFNG FOXP3 PMC10243112__F7 Machine Learning Reveals Lipidome Remodeling Dynamics in a Mouse Model of Ovarian Cancer PC C6 TG PMC2679172__F1 Crosstalk at the initial encounter: Interplay between host defense and ameba survival strategies GAL CP PMC2756331__F1 Trk receptor tyrosine kinases and major signal transduction pathways BAD NGF FRS2 GRB2 GSK3A NTS RHO BDNF CDC42 PMC4123471__F6 Extracellular Matrix and Liver Disease RAE1 BCL2 BAX PMC4229247__F4 Pathways for initiation and maintenance of psoriasis TLR7 TLR9 TNF PMC4760771__F7 HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells HEL-S-44 SMO PMC8268646__F1 From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment IL17RA TRAF6 IL25 IL17RB TRAF2 IL17RC PMC9280173__F9 Antiproliferative and apoptotic potential of Glycyrrhizin against HPV16+ Caski cervical cancer cells: A plausible association with downreguation of HPV E6 and E7 oncogenes and Notch signaling pathway BAD CCND1 CDK4 BAX PMC2783351__F2 “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia CD14 TLR4 IRAK1 TRAF6 IRAK4 MYD88 TIRAP TAB3 PMC5372728__F2 Effect of chronic alcohol intake on mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in white adipose tissue from mice TSC2 EEF2K TSC1 EIF4E EIF4B PMC5372728__F1 Lipolytic and lipogenic pathways in white adipose tissue LPL FASN CD36 HEL-S-5 PMC8999811__F1 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs MED25 MYC PMC8999811__F2 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs MED25 MYC PMC6750278__F1 Diagram illustrating damage processes and pathways thought to contribute to HC loss due to acoustic overexposure SRC ARHA JUN CDC42 PMC4566117__F4 Surfactant metabolism PC NKX2-1 SFTPC ABCA3 SLC34A2 CEBPA SFTPB FOXA2 PMC8999811__F4 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs BIN2 TDP1 CPD PMC5987207__F1A Systems and synthetic biology approaches in understanding biological oscillators WEE1 MALL APC MAL PMC8025964__F6 Summary of SEPT6-regulated Hippo/YAP signaling pathway in HCC MMP2 CCND1 LATS1 PMC6750865__F1 Possible integrated mechanism of cell injury and its relationship with microcephaly ZIKV-induced and cell death NLRP3 RIPK1 IL33 RIPK3 MTOR AIM2 IRF-1 ZBP1 BAX PMC6077295__F2 Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis BRAF IGFBP7 PMC3954160__F1 Insulin signaling pathway PRKCI BAD ACACA GSK3B INS GCK GYS1 PYGB MTOR HRAS CRK CALML6 INSR TSC2 LIPE SLC2A4 SOCS4 PKLR GRB2 ARAF CBLC FASN PMC6581573__F2 Stylized diagram showing the synthesis, degradation, release and uptake of monoamines, synaptic effectors and targets of methylphenidate TH HTR1B TPH2 DRD1 SLC6A2 DRD2 DRD4 DRD5 DRD3 SLC6A3 ADRA2A SLC18A2 DBH HTR1A PMC7008497__F3 Signals 1 and 2 for nod‐like receptor protein 3 (NLRP3) activation may be delivered by cGAS or TLR9 CGAS TLR9 IL1B PMC3047110__F6 Proposed model for ERG functions in prostaglandin signaling pathway COX2 HPGD COX1 ERG PMC316535__F6 Genetic models for ptp-2 signaling during (A) oogenesis and (B) vulval development EGF EGFR GRB2 PMC4638384__F2 Regulation of the Hippo pathway in Drosophila HEL70 ZYX SCRIB WBP2 PMC4638384__F3 Regulation of the Hippo pathway in mammals SIAH1 AMOT NF2 SCRIB LATS1 RHO CDC2 SIAH2 WBP2 LATS2 HEL-S-31 PMC8576247__F4 Clinical values and potential pathways of miR-183-5p in gastric cancer: a study based on integrational bioinformatics analysis RELN MAPK10 CACNA2D3 MTOR NGFR GHR WNT2B XB COMP NTRK2 CTNND2 PRICKLE2 COL4A5 PMC8247090__F4 Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway TH PTCH2 BCL2 KIN GLA PMC6639958__F8 Proposed model of MEK as a key regulatory pathway of the IFN response against RV and RSV in airway epithelial cells STAT2 EGFR HEL164 IRF3 IFNAR2 IFNAR1 TLR3 STAT3 PMC4638384__F1 Inhibition of YAP/TAZ transcriptional coactivators by LATS1/2 TEAD3 VGLL4 TEAD4 LATS1 TEAD2 PMC4638384__F4 Therapeutic targeting of the Hippo pathway TEAD3 TEAD4 LATS1 RHO LATS2 TEAD2 PMC10418941__F2 Molecular crosslinks produced by the interaction of the HSCs and LSCs CYR61 KLF4 CDH2 PMC3773501__F1 NOD2, an Intracellular Innate Immune Sensor Involved in Host Defense and Crohn's Disease ATG16L1 IRF3 IRF4 NOD2 MAVS PMC5495050__F3 BRD4 pathway in acute myeloid leukemia (AML) cells FLI1 NSD3 ERG TEF CHD8 MYC CDK6 BRD4 PMC10418941__F3 LSCs’ microenvironment in relation to epigenetic modification RUNX2 CTCF VEGFA MYC CD44 LAMB3 PTEN IL6 TNF PTPRC TLR7 TLR4 CD68 PMC10418941__F4 LSCs mechanism that employs fat as fuel SOX2 ALOX5 PMC7933526__F10 Mechanism underlying renal-protective effect of QYDP SMAD2 SMAD4 TF PMC8504268__F1 Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88 CD14 LBP MYD88 TNF IL1B TIRAP PMC8475840__F1 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection EGLN2 HK2 PMC5442467__F8 Summary of the impact of keratins on the Notch1 signalling pathway HEY2 NOTCH1 PMC3855091__F6 Foxa2 deletion leading to premature aging and age-onset obesity TSC1 SESN3 TRIB3 IRF3 MTOR STAT5B DDIT4 FOXA2 PMC8834130__F1 Oral Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: Salivary Gland Dysfunction and Mucosal Diseases PC BCR GC CD40 CD80 ICOS PMC4464753__F7 Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus IGF1R IGF1 IGF2 TNF BDNF IRS1 IL1B APOE PMC2837572__F2 An overview of the signalling pathways mediated by TNFA in metastasis CSN2 TNF PMC9562907__F1 Complement in nonalcoholic fatty liver disease C1S PMC2837572__F1 Downstream signalling pathways of TNFA TRADD TRAF2 FADD PMC6601209__F1 Graphic depiction of the gene engineering strategy and glycoproteomics workflow GALNT5 GALNT8 GALNT7 GALNT4 C1GALT1 GALNT12 GALNT16 GALNT10 GALNT3 GALNT1 GALNT9 PMC4601184__F1 IGFR1, a possible target in tumor progression and metastasis EGF IGF1 MMP2 MMP9 EGFR TF PMC6073226__F4 Mechanism of modulation on sphingolipids by chrysin (A), curcumin (B) and genistein (C) SPHK1 SPHK2 SMS PMC7469703__F5 CSHMM predicts the precise timing of Wnt modulation as a determinant of cell fate AXIN2 WIF1 NKD1 PMC3749695__F8 Cumulative scheme adapted from the data published in (, –, , , , , ) showing components of pathways implicated in regulating the life span in Drosophila and their interactions TSC2 TSC1 KEAP1 PTEN PRX RHEB PMC10750282__F2 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention TBK1 PDE3B CGAS VSIG4 MMP9 IRF3 LATS1 CCL2 TLR3 GSDMD TLR4 VCAM1 ABCC8 TRAF2 ALDH2 PMC8802753__F3 Polyphenols and omega-3 PUFAs: Beneficial Outcomes to Obesity and Its Related Metabolic Diseases IL10 IL13 IL6 PMC6852943__F2 Inhibitory effect of miRNAs on their target molecules in the UPS pathway UBE3A USP2 HEL-S-71 UBE2I UBE2B CBX4 UBE2A PMC7786163__F2 Links among COVID-19, cytokine storms, and HF STAT1 STAT2 CCL2 IL1B CCL3 PMC10750282__F3 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention TBK1 CGAS ULK1 SQSTM1 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 MTOR IFNAR1 IRS1 NLRP3 TLR4 AIM2 PMC6505634__F3 MEF-2 isoforms' (A-D) roles in development and tumorigenesis MYOT FOS MTOR RHEB PMC7796017__F2 PI3K/AKT/mTOR signaling pathway and breast cancer IGF1R FGFR1 EGFR RHEB PMC4593004__F2 Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan NR5A2 HIVEP3 KCNQ5 RAB4A SLIT3 SOX17 PLCB4 CMTM8 MAST2 PSD3 ROBO1 MLSN2 EXOC2 PMC10882078__F7 TNF signaling pathway in atherosclerosis-related and non-related to CKD TRADD TRAF3 CASP10 TNF TRAF2 SP3 FADD ITCH PMC7564975__F2 Different ratios of STAT3A/STAT3B and their functions in therapy sensitivity EGFR SRC STAT3 PMC4618389__F1 Vulture-specific genetic change in immune system CD14 NOD1 IRF7 LBP NOD2 PMC5088527__F7 Linking the circadian clock with the NAD+ salvage pathway NAMPT SIRT1 PMC9005797__F1 Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events APC CD80 PMC3594751__F7 Schematic view of the roles of S-PCNA and Srs2 in the rescue of stalled replication forks RAD51 POLN RAD18 PCNA POLM PMC7544739__F2 Interactive roles of SOCS1 and SOCS3 in TLR signaling TBK1 TLR4 SOCS3 IRF7 TRAF3 TRAF6 IRF3 MYD88 SKI TLR3 SOCS1 MAL PMC5088527__F2 Biosynthesis pathways of acetyl-CoA and NAD cofactors, and their involvement in chromatin-related processes NAMPT VIT SIRT1 PMC4511319__F4 Signaling network of endothelin axis (ET) and micro ribonucleic acid (miRNA)-200, the ET axis can be influenced by miRNA-200c on different pathways (red arrows: induction of pathway; black arrows: blockade of pathway) SMAD2 ZEB2 PMC6731444__F8 A scheme for DMF induced SOCS3/JAK1/STAT3 signaling pathway in HCC cells SOCS3 VEGFA JAK1 DKFZp686F0183 STAT3 PMC7145703__F4 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics STAT1 CTSK CYLD NFATC1 BASH GAB2 IRF9 IFNE FHL2 GRB2 SYK PMC3721332__F2 Interactions between nTreg (A) or IL-2 activated inducible Treg (Tr1) with effector T cells (Teff) mediated by the adenosine and PGE2 pathways COX2 FOXP3 PMC4516433__F5 Cerebral nitric oxide represses choroid plexus NFKB-dependent gateway activity for leukocyte trafficking CXCL10 CCL2 CSA2 TRAF2 IFNG PMC10215584__F5 PPI network analysis according to STRING database and KEGG pathway enriched in DEPs in the groups of (A) MRC vs GALNS PRKCB COL3A1 MANBA HMGCL HEL-S-273 LAMA4 MRO SLC26A3 NR1A2 PLIN4 PMC7145703__F5 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics PLCG1 EGF NGF TRADD PLCG2 COX2 TLR4 BCR ATM BASH EN1 IL1B CD14 LTB PARP1 CNTF LTA VCAM1 TNFRSF1A LCK LBP LYN LTBR LAT TIRAP PMC5938338__F7 Schematic of Ca2+signaling pathway activated by alkaline stimuli to dentin surface and PLC-coupled receptor activation in odontoblasts TRPA1 PMC7915495__F3 Protective effects of small-molecule natural products on OS in CKD SFN ERG GSK3B CGA SIRT1 SIRT3 PMC4911704__F1 MTOR in maintenance of glomerular epithelial cells TSC2 ULK1 TSC1 TBC1D7 SGK1 PMC9504399__F3 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos BAMBI SMAD6 SMAD4 SMURF1 SMAD1 DKFZp781O1323 PMC9504399__F4 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos FER TBX1 RIPPLY3 GRB2 ANOS1 MEIS3 IRX1 FLRT3 PMC5949255__F3 Deciphering p53 Signaling in Tumor Suppression ULK1 SCO2 ATG2B SLC7A11 XPC DDB2 RHO ULK2 ATG10 DNMT3B TET2 TET1 MDM2 THBS1 UVRAG MSH2 CALD1 PMC7391449__F1 Cellular Oxygen Sensors EPO TFRC BNIP3 HIF1A HK2 PMC5797050__F3 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis DAP OMA1 PMC5797050__F4 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis NPAT CD14 MAX FLNA ECSIT JUN MPL PMC10866657__F2 BMP9-10/ENG/ALK1/SMAD4 signaling pathway maintains vascular quiescence by repressing angiogenic pathways PIGF SMAD2 TGFBR1 VEGFA SMAD4 ENG PTEN CDK6 BMP10 CDK4 VEGFB SMAD1 SGK1 DKFZp781O1323 PMC5858934__F4 Model for RHO/ROCK-dependent regulation of trophectoderm-lineage specification AMOT NF2 RHO PMC4303468__F18 Generation and metabolism of H2S PMC4060729__F2 Flowchart showing the induction of ER stress and its physiological outcomes during coronavirus infection EIF2A XBP1 PMC6667284__F1 Intracellular interactions and fates of microbes opsonized with C3 in the extracellular milieu HEL-S-62p ATG16L1 MAVS PMC8711024__F7 Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL-mediated NFKB and JNK and their downstream signalling pathways NFATC1 DCSTAMP TRAF6 PMC9247874__F3 Long Non-coding RNAs With In Vitro and In Vivo Efficacy in Preclinical Models of Esophageal Squamous Cell Carcinoma Which Act by a Non-microRNA Sponging Mechanism E2F4 SUV39H1 SPRY4 ATM CDKN2C GADD45A HCTP4 TG PMC3352318__F7 Association of mitochondrial peptidyl Cys with functional networks according to reduction and oxidation of Cys residues IKBKE EGF UQCRB TNIP3 LTC4S UQCRFS1 KIF11 MDH2 GOT2 PC NDUFS1 UQCRC1 UQCR10 PNO1 UQCRHL ETFA SDHA SDHB UQCRQ ETFB SDHC MTCH2 VEGFA NDUFAB1 TNF SLC25A4 UQCRC2 TUFM NFKBIA MGST1 UQCRH ERBB2 NDUFB3 CYC1 GRB2 SLC27A1 HEL-S-51e ECHS1 TGFB1 ACADM GLUD1 PMC7827005__F1 Activation of signaling pathways (selected) in MM cells in the BM microenvironment PDC BAD WNT3A IGF1 MYC RELB DKK1 MTOR STAT3 PMC7827005__F2 Cell adhesion-induced activation of signaling pathways IGF1 VCAM1 BCL2 IL6 EZH2 PMC6134795__F1 Composite pathway using the KEGG pathway analysis, a composite pathway was generated based on the canonical mapping of the phosphorylated proteins independently associated with increased % collagen (red) in the liver LIMK2 LIMK1 TRAF2 PMC5636987__F6 Proposed working model: POPX2 regulates the TAK1-IKK-NFKB pathway during DNA-damage-induced apoptosis ATM TRAF6 MAP3K7IP1 TAB3 PMC6544937__F5 miR-15/107 family targeted genes in cell cycle KEGG pathway calculated by miRPath v3.0 web-server CREBBP CDK2 REL DBF4 PRKDC RAD21 CDK7 PCNA PMC3352318__F6 Association of nuclear peptidyl Cys with functional networks according to reduction and oxidation of Cys residues HNRNPAB HNRNPL RNMT RBM42 IPO5 MAGOH DBF4 DKFZp686L0365 SF1 SRC PCBP1 HNRNPA2B1 ANP32B KIR2DL4 KHDRBS2 PRKDC NXT1 THOC2 ELP5 CLIC1 XPOT THRAP3 CASC3 TNPO2 DEK RBM8 TNF SNUPN HNRPA3 U2AF2 RAN NUMA1 PCNA SRP19 WBP11 PMC12102218__F8 Diagram illustrating the mechanism through which ISM5939 potentiates antitumor immune responses CGAS ENPP1 HEL-S-92n PMC3352318__F4 Association of cytoplasmic peptidyl Cys with functional networks according to reduction and oxidation of Cys residues EPCAM CAP1 MYO1C ATP1A1 FLNA ANXA4 PPP2R1A FLNB STK39 EIF2S2 EIF2S3 EEF1B2 CCT7 RPL10A ACTN4 HEL-S-133P HEL-S-281 FASN ANXA1 TUBB PLEC HEL-S-34 CAND1 HEL-S-87p PABPC4 PS1TP5BP1 HEL-S-69p HEL-S-68p TUBA1A YWHAQ CCT4 AIMP2 CLTC RPS3 HEL-S-93 PMC7736605__F1 Autophagy influence on tumor-associated antigen presentation 1 TH CD80 PMC6329627__F1 PG biosynthesis, receptors and signalling pathways COX1 RHO PMC2567408__F8 NCAM upregulation leads to a functional switch FYN FRS2 SHE PMC3302445__F7 How BRG1 and CHD4 antagonistically influence Wnt signaling during yolk sac vascular development CHD4 PMC6329627__F2 Lymphocyte‐mediated chronic inflammatory responses IL33 IL25 TSLP PMC5850516__F1 Transforming growth factor B activated kinase 1: a potential therapeutic target for rheumatic diseases TLR5 TLR4 TRAF5 IRAK1 TRAF6 IRAK4 IL6 MYD88 MAP3K7IP1 TRAF2 PMC6329627__F3 Molecular mechanisms for PGE2‐cytokine crosstalk in facilitation of adaptive Th1 and Th17 cell responses IL2 CD40 CRTC2 IL23R STAT3 PMC4926172__F1 Schematic overview of viruses that subvert the PI3K/Akt/mTOR signaling pathway TSC2 TSC1 PTEN MTOR ITGB1 RHEB PMC4926172__F2 Downstream targets of mTORC1 ELF3 CDC2 MTOR RHEB PMC8328766__F3 Astrocytes: a double-edged sword in neurodegenerative diseases SOCS3 DDC RHO MTOR TF STAT3 PMC8910224__F4 Micro-Current Stimulation Suppresses Inflammatory Responses in Peptidoglycan-Treated Raw 264.7 Macrophages and Propionibacterium acnes-Induced Skin Inflammation via TLR2/NFKB Signaling Pathway TRAF6 MYD88 PMC8278373__F2 Therapeutic approaches targeting the GFB in clinical or late preclinical development TRPC5 TRPC6 ARHA RAC1 CDC42 PMC11757730__F7 Anti-inflammatory effects of chamuangone in lipopolysaccharide-induced murine (Mus musculus) RAW264 TLR4 MYD88 PMC3855406__F2 Signaling pathways of NFKB activation TRADD TRAF6 CD40 FADD LTBR PSD PMC8678573__F3 Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System FYN PC SYK SNAP23 PMC7658535__F7 Signaling pathways induced by prolonged exposure to H IKBKB BIRC2 GADD45B FOXO4 NOD1 ATG12 BNIP3 BCL6 PMC8306561__F3 Autophagy Inhibition in BRAF-Driven Cancers TSC2 ULK1 TFEB BRAF ATF4 EIF2A MDM2 RHEB PMC5003635__F3 Oridonin regulates multi-signaling pathways to display corresponding multifunctional effects KEAP1 APAF1 BAX PMC8306561__F2 Autophagy Inhibition in BRAF-Driven Cancers ATG3 ATG101 ATG10 ATG14 DKFZp686F0183 PMC7710892__F3 The CoQ10 biosynthesis pathway COQ8A COQ3 COQ2 COQ9 COQ6 COQ5 PDSS1 COQ7 COQ8B PMC3980962__F1 Origins and implications of pluripotent stem cell variability and heterogeneity FGF4 SOX2 LIF TBX3 OTX1 ZIC2 SOX6 SMAD1 OLIG2 RBL2 BMP4 STAT3 PMC11064142__F8 A) Interaction of mir15a/16-5p cluster and mir-7641 with targeted genes involved in intrinsic and extrinsic signalling pathways of apoptosis MEI1 CDKN1B VEGFA MYC TLN1 PTEN BCL2L11 CCNE1 E2F7 CCND1 BCL2 MCL1 JUN PCNA BAX PMC3744446__F1 Past Visits Present: TCF/LEFs Partner with ATFs for Beta-Catenin–Independent Activity LEF1 ATF2 TCF4 PMC7275976__F1 SARS-CoV2 replication cycle and potential targets of CQ/HCQ TLR7 ACE2 PMC7838196__F10 AGE-RAGE signaling pathway in diabetic complications DAO TF SELE PMC8475840__F4 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection TSC2 TSC1 CASTOR1 SIRT1 PMC2858431__F1 Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway TSC2 TSC1 PTEN EIF4E MTOR RHEB PMC9022965__F2 Four enzymatic pathways that drive PL remodelling PC PODN HEL-S-5 PMC5896114__F4 Location of si:ch211-167b20.8, socs9, eif4e1c and CALML6 in the insulin signaling pathway TSC2 BAD GRB2 INS MTOR ELF4 FOXO1 RHEB INSR CBL PMC3755284__F1 Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization NHS IL13RA2 NPS C6 HEL-S-162eP PMC3159114__F1 Modulation of cellular reactive oxygen species (ROS) GPX1 NOX4 PRX PMC8573605__F1 Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data PDC RELA RELB PMC4762627__F4 NFE2L2-Regulated Antioxidant Response in Activated Microglia ME1 GCLM ME2 EPHX1 SQSTM1 GCLC FTH1 GSK3B HEL-S-107 TXN HEL-S-94n USP14 CCT7 HEL-75 PPIB VCP CLPP PMC12203236__F2 Targeting Molecular Pathways in Breast Cancer Using Plant-Derived Bioactive Compounds: A Comprehensive Review EGFR PTEN MTOR SKP2 STAT3 PMC9506445__F1 Association of Homologous Recombination–DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers CHEK2 PALB2 FANCD2 ATM BRCA2 BARD1 RAD51 ATR BRCA1 PMC7802183__F7 As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway PDX1 PRKCE NR5A2 DEFA4 CSTB FAM83F CNR1 IFNA7 HIRIP3 TIMD4 NDUFB8 PAX5 NMNAT2 LPP RADIL ARL15 DCTN3 TPTE CLCN2 SPANXN5 OCSTAMP FBL PCDHGA7 PLEKHG7 RGS4 SLC6A17 ELAC1 SPDYE3 NGL1 AK4 GRP SH2D1A GNG12 DBI PARP11 B3GALT2 APOH NPFF ZNF549 SYT2 APPL1 IFNA17 PMC3164150__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-IR) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) IGF1R IGF1 IGF2 PMC7603197__F1 Aberrant FGF/FGFR signaling in breast cancer FRS2 GRB2 APP CBL PMC3164150__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway TSC2 BAD TSC1 IGF1 IGF2 GRB2 PTEN MTOR IRS1 PMC4940047__F2 Regulation of hepcidin production TWSG1 EPO HAMP GDF15 HFE IL6R TFR2 STAT3 PMC3585130__F1 The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network DPH2 DPH5 DPH3 EEF2 DPH1 PMC3585130__F2 Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network DPH2 DPH5 DPH6 DPH7 LAP3 NDE1 DPH1 PMC4860420__F2 Reelin signaling mechanisms in brain development and function FYN VLDLR SRC DAB1 MTOR CRK PMC4330253__F3 Illustration of molecular pathway for significantly associated single nucleotide polymorphism (SNP) loci in the metabolic syndrome genome-wide association study (GWAS) CENPH BCL10 INCENP CCL20 ZW10 CENPE ZWINT CARD10 APOE AURKB PMC9923939__F1 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action EGFR CCND1 PTEN CD19 BAX PMC2277216__F1 Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history TLR7 TLR9 IRF7 IRF8 IRF3 IRAK4 MYD88 PMC9923939__F2 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action CD14 TRADD TRAF6 MYD88 TNF TRAF2 PMC6929103__F3 KEGG based pathway analysis of 86 genes reveals their significant role in different pathways, as shown in the figure, such as immune response pathways ATP2B4 CD34 LAMA4 PPIF PTPRC PLN EDNRA EDNRB KDR opn CAV2 PECAM1 MEF2C CD36 PMC9923939__F3 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action TRADD RAF1 TNF TRAF2 PMC9923939__F4 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action BAMBI MMP7 APC CCND1 PMC9923939__F5 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action EGF BAD EGFR GSK3B SRC PTEN MTOR TGFA STAT3 BAX PMC9923939__F6 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action CDK2 MDM2 CDK4 CDK6 BAX PMC4878077__F4 Shows the schematic presentation of the IFNA/B and IFNG receptors linked to the Jaks for the TO-VS-IFN/SAV3 and TO-VS-SAV3 STAT1 STAT2 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IFNG PMC8377872__F5 Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus STXBP3 OGT RAB11FIP2 PMC9923939__F7 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action NODAL SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC9923939__F8 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action TSC1 GSK3B TBC1D7 PTEN DEPTOR PMC9923939__F9 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action DHH IHH PTCH1 GLI3 MYC SHH SMO KCTD11 PMC4878077__F5 Shows Jak/stat pathway analysis for the TO-VS-IFN/SAV3 and TO-VS-SAV3 using the KEGG pathway software analysis PIM1 EPO IL3 IL2 IL6 CBL PMC7386875__F1 Proposed mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, and coronavirus disease 2019 (COVID-19)-associated thrombosis FURIN ACE2 TF TMPRSS2 PMC4528959__F6 Quantitative phosphoproteomic analysis of IL-33 mediated signaling F2 APC INS ABI2 RHO HEL114 FGD1 PXN CDC42 PMC7386875__F4 Treatments for targeting coronavirus disease 2019 (COVID-19)-associated thrombosis HMGB1 ACE2 TMPRSS2 PMC3161051__F7 Rad6B/Beta-catenin regulation in breast cancer cells with autocrine Wnt activity APC LRP5 LRP6 PMC4578258__F1 The schematic model for the regulation of the transcription of the srf operon network involved in two extracellular signaling peptide-mediated quorum sensing in B COMP PMC6424728__F1 Promoting immune evasion by Hippo pathway EGF CXCL5 EGFR IL8RB PMC3934928__F2 Cell biological view of Toll-like receptor function: regulation through compartmentalization CD14 TLR5 TLR7 TLR4 TLR9 TRAF3 MYD88 TIRAP PMC3617288__F8 Model for the new PLD2-Fes-Jak3 pathway PC PLD2 FES JAK3 PMC8628936__F2 Organizer and Its Signaling in Embryonic Development NODAL SMAD2 APC GSK3B LRP5 SMAD4 SRC PMC3119055__F4 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events DBI PLAT EGFR FHL2 DIPLA1 RGS16 FOXO1 IGF2R FRZB PMC6953127__F1 The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases ATG12 ATG3 WIPI2 ULK2 PMC3119055__F5 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events DBI DCN PLAT PLG DPP4 HEL110 MTOR DIPLA1 FOXO1 IGF2R PMC3296187__F1 Schematic representation of the RKIP signaling pathway and its effects on metastatic progression to the bone HMGA2 CXCR4 BACH1 PMC9705593__F1 Crucial role of T cells in NAFLD-related disease: A review and prospect CXCR3 CXCL10 CCL20 STAT3 PMC6885781__F4 Toxic function evaluation in cancer EVs FGA HEL-S-62p KPRP HRNR HMCN1 ITIH2 HEL-S-2a APOB HEL-S-78p JUP HP ANXA2 HBB SERPINA1 PMC3678031__F2 The amygdala and medial prefrontal cortex: partners in the fear circuit CLC CS PC PMC6287101__F7 Overview of complement cascade activation and targets of inhibitors HEL-S-62p CD59 CD46 MASP1 IL13 FH C7 MASP2 CD55 C4A IL1B PMC2924916__F3 P-values for testing association of the genes within the MAPK signaling pathway with RA in NARAC studies EGF BRAF NGF MOS MYC RRAS TRAF6 FLNB NLK MAX ECSIT BDNF TRAF2 JUN PMC4377868__F1 Biological roles of sulphate and pathways of sulphate homeostasis CTH PAPSS2 CDO1 SOST SUOX PMC7328459__F1 Dysregulation of Cell Death in Human Chronic Inflammation RIPK1 TRADD TRAF5 CYLD RELA SHARPIN RIPK3 TNF MAP3K7IP1 OTULIN TRAF2 FADD PMC3398916__F7 The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network TIAM1 APC GSK3B CDC42 PMC2924916__F2 P-values for testing association of the genes within the MAPK signaling pathway with RA in WTCCC studies CD14 EGF NGF MOS FLNA CDC25B TNF CRK TAOK2 PRKCA NLK NTF3 MAX GRB2 JUND ECSIT BDNF TRAF2 PMC3008507__F5 A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets SNAI1 F10 CDH24 PLK1 NPM1 LAT2 MAPK14 SAA1 RB1 ONECUT1 HOXB4 TBP GSTT2 EIF3B MYCBP2 LGI1 NRG2 SLC26A2 UGDH LRP6 NPPC PROCR CCDC91 FOXD1 KLHDC3 ATP10A GKAP1 ASGR1 CHST6 MDFI GTF3C1 GTF3C2 GTF3C5 MPZL2 POLR3F KCNJ10 RASA4 PLEKHA6 CDX1 POLR3C COX1 LTC4S EWSR1 EIF5 CHEK2 RRM2 LZTS1 KITLG GNAZ YWHAG PHB2 BTN2A1 RBL2 TMEM126A NASP KLF5 SERPINB8 DDR2 ATP8B2 GIG8 SART3 KIF20A PNKP TRAF6 ITM2C DHPS BATF IL16 HEL-S-76p FZD2 SNW1 JUNB HEL-117 FZD10 MGAT3 AIF1 DOCK11 EIF4G1 P2RY2 TMEM109 AK5 IL27RA APOH LAT ALDH2 F13A1 PTPRN2 UMPS CD300A EIF4EBP1 FZD9 SEC31A PTPN11 GJB2 SAMD9 RPS6 GJB1 EIF4B LIF WASF3 SSB RPL6 NR1C1 RBPMS CDC42EP3 MARCKSL1 GJA1 ACTR3 PMC4695001__F7 Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo MDM2 ARV1 GAL PMC8703004__F2 Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells BCR IMPACT APC CD36 PMC5076483__F4 Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events TDG DNMT3B PMC11889934__F3 Molecular modifications of lactylation in cancer YTHDF2 KAT5 ULK1 SEMA3A EP300 VCAM1 MADD VEGFA HEL-S-133P PER1 GPR37 STAT3 PMC11889934__F4 Anticancer strategies targeting lactylation LATS1 SPOP HIF1A HEL-S-133P HK2 CTGF SIRT3 PMC4805479__F2 Involvement of dWAT in Hair Follicle (HF) Synchronization.Synchronous cycling of HFs is connected with long-range paracrine signaling VIT NR1i1 SHH PMC11192909__F0 Mechanism of NGR1 in alleviating colitis APC LRP5 LRP6 GPR49 PMC8096981__F2 Inflammation-Mediated Angiogenesis in Ischemic Stroke BAD EPO EGFR PTEN PMC8741355__F4 Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics UBC PLTP HEL-S-28 LPL ACD EHHADH CYP7A1 PMC2756763__F1 Aromatase: synthesis of estrogen in postmenopausal women and its inhibition by aromatase inhibitors STS HSD17B1 PMC7378193__F7 Regulatory network of MYO18B mRNA that reflect the survival outcome in hepatocellular carcinoma MYO1B MYL5 IFI27 CEBPB MYO18B IFNG PMC7183444__F3 Hypoxia/re-oxygenation-related KEGG pathway and differentially expressed genes(a) von Willebrand factor (VWF), complement component 1, q subcomponent, A chain (C1QA), and complement and coagulation cascades pathway HEL-S-62p CCL4L2 CD9 F10 BAD TFPI CS DAO WAS RHO CCL3L3 CPB2 C9 C1QA PC MAFK F2 FH CXCR4 F3 VWF F7 CR2 DOCK2 PMC4512830__F6 Examples of IPA software outcome: hsa-let-7 and their target genes in Human Embryonic Stem Cell Pluripotency Pathway FOS ATF2 SP1 JUN CP PMC2074956__F3 Schematic representation of the carbon catabolic pathway, the bifid shunt, and oxalic acid degradation AGA PMC3118436__F2 Metabolic remodeling in cancer cells and regulation by signaling pathways involving oncogenes and tumor suppressor genes TIGAR HEL-S-26 MYC HEL-S-133P HK2 GLS PMC3644824__F2 A schematic diagram of Mycobacterium tuberculosis (Mtb) infection and clearance via the autophagic pathway ESX1 IRGM RAB8B IFNG PMC6477881__F2 The mTOR-signaling pathway in ASD NF1 TSC2 TSC1 PTEN EIF4E MTOR RHEB PMC6207557__F1 Mechanisms by which rLrp inhibits the production of LPS-induced cytokines TLR4 SOCS3 GSK3B TRAF6 MYD88 PMC7306500__F2 Protein-protein interaction network (STRING database) generated by combining all biomarkers of different omic types, reviewed earlier in the report HEL-S-91n TNFRSF14 ADAM12 APOC3 TFRC AMBP HEL-S-104 PRDX3 FSTL3 SIAE TIMP3 EPHX2 KRT13 SERPINA1 PLCD3 SMS BHLHB2 GCLM INVS MYCBP2 HS3ST2 PROX2 CYP11A1 ATF3 ATP2B1 PLAC1 HEL111 CD72 COX17 HP NFKB2 CRH DBP INHA ADRA1D PAPPA2 HEL113 CDX1 SLC2A6 DPP7 PSMD1 FGF14 NPVF LMCD1 PER3 CSHL1 PMC7322056__F6 Role of HX109 in prostate epithelial-macrophage crosstalk and inflammatory response of macrophages TLR4 CCL4 STAT3 PMC7749079__F1 Hippo signaling in embryogenesis and development AMOT VGLL4 SRC LATS1 RHO LATS2 PMC12238593__F5 Deregulated molecular signaling pathways and crosstalk in glioblastoma EGF HGF EGFR APC GSK3B LRP5 LRP6 PTEN TNF MTOR DEPTOR RHEB TSC2 NF1 LEF1 TSC1 NOTCH1 CSA2 JAK1 IL1B PMC12238593__F6 Key immune signaling pathways regulating tumor-associated immunosuppression IDO1 SMAD2 ZAP70 SMAD4 SRC MTOR PMC12238593__F4 Genetic alterations driving glioblastoma pathogenesis MYB BRAF SOX2 AREG MN1 EGFR PTEN RB1 MTOR CDKN2A CDC20 ATM CDK2 MDM2 CDK4 ATR PMC12238593__F9 Transcriptional and epigenetic regulation and functional dynamics in CD8+ T cell exhaustion CXCR3 RUNX3 GIG8 FOXO3A F3 TOX ID3 FOXO1 PMC4014333__F1 Biosynthetic pathway of prodigiosin PIGF HBM PIGC PIGH PIGM PIGA PIGN PIGL PMC4765774__F4 N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli CLPS CLPX CLPP PMC5323377__F10 Schematic representation of the difference between Ctenopharyngodon idella melanoma differentiation-associated gene 5 (CiMDA5) and C IRF7 IRF3 PMC3975838__F1 Janus kinase 2 (JAK2)/signal transducer and activation of transcription (STAT) and hedgehog (Hh) signaling pathways in normal development (A) and mechanisms of Hh signaling in cancer (B) PIM1 SUFU GLI3 CCND1 BCL2 SMO MCL1 PMC7724349__F8 Selaginellin B induces autophagy and apoptosis in ASPC-1 and PANC-1 cells through activating the JAK2/STAT3 signal pathway BCL2 STAT3 PMC3224393__F1 Reaction scheme for EGFR signal transduction pathway in H1299 cells EGF EGFR GRB2 CBL PMC9635867__F1 RNA m6A methylation regulators in endometrial cancer (Review) YTHDF2 F10 IGF1R IGF2BP1 PHLPP2 SOX2 WTAP MTOR COL1A1 IRS1 SOX4 YTHDF1 METTL14 METTL3 CCND1 PEG10 HOXB13 PMC6291723__F4 Main lipid-lowering effects of berberine through the APMK pathway HNRNPD LDLR TG PMC3385990__F3 Gp130 mediated IL-6 family of cytokines signaling pathway SOCS3 GRB2 IL6 SOCS1 STAT3 PMC7418153__F1 An overview of Wnt signaling pathway ZNRF3 RNF43 APC GSK3B LRP5 LRP6 GPR49 PMC7013402__F2 Greatwall- Endosulphin Alpha (ENSA) pathway in the control of G1 and G0 RICTOR WEE1 PPA2 NAT1 CDC26 HEL-S-66p PMC7418153__F2 An overview of non-canonical Wnt signaling pathway DAAM1 PTK7 ARHA RYK RAC1 CDC42 PMC2913986__F6 Gene Chip analysis reveal SOX11-induced regulation of Rb-E2F and TGFB signaling pathways MAP3K7IP1 PMC9604510__F2 Cell Component and Function of Tumor Microenvironment in Thyroid Cancer SRC PMC8835893__F5 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance DHH IHH SUFU SHH SMO DYRK1B PMC7758837__F1 Emerging therapies in Parkinson disease — repurposed drugs and new approaches SNCA PINK1 LRRK2 PARK2 GDNF LAG3 PMC8835893__F2 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance NUMB SRC ARHA SMO RAC1 MTOR PMC9246413__F2 Temozolomide – Just a Radiosensitizer? ATM ATR MPG PMC5911630__F7 The role of ACSS3 as a prognosis biosignature of GCa GCA CS SC5D LDLR ACSS3 MVK PMC8835893__F1 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance DHH IHH SUFU SHH SMO PMC5366285__F9 Cartoon illustrating a novel signaling pathway for the coordinated regulation of Rho and Rac signaling in epithelial invasion DOCK5 RHO GIT2 CRK PMC8352204__F3A Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors CELF4 MYB CYBA ZNF71 UACA ZNF827 TGM3 DKFZp686O2396 MED10 MCU GJB7 PMS1 DYNAP LITAF TGM1 SEC62 PMC4027041__F1 Hepatic S-adenosylmethionine (SAMe) metabolism HEL-S-61p HEL-S-182mP PMC4546523__F2 Biosynthesis of heparin/heparan sulfate and chondroitin sulfates CS UST GAL GLA PMC5228377__F6 The signaling pathways involved in wogonin-induced autophagy ULK1 CYLD MTOR PMC9477170__F3 Inflammation resolution concept NLRP3 COX2 COX1 IL13 PMC11419411__F2 Molecular mechanisms and pathways associated with PCa bone metastasis cells (By Figdraw) IFITM3 TBX2 CDK5 SMAD4 CCL5 TNF STAT3 FZD8 PMC2727884__F2 Mechanism of action of sorafenib EGFR VHL TGFA PMC11787113__F2 Phenotypic and functional characteristics of tumor-infiltrating B cells determine their overall impact on tumor progression or suppression FOXP3 PMC9635867__F2 RNA m6A methylation regulators in endometrial cancer (Review) YTHDF2 TSC2 METTL14 TSC1 PHLPP2 METTL3 PTEN RHEB PMC3864081__F1 DAMP signaling through different PRRs IL16 NOD1 IRF7 IRF3 MYD88 NOD2 TIRAP PMC11640923__F4 Iron handling in the brain HAMP HEPH PMC8388390__F4 Effect of GP19 Peptide Hyperimmune Antiserum on Activated Macrophage during Ehrlichia canis Infection in Canine Macrophage-like Cells IL10 IL13 IL11 IFNGR2 IL24 TNF IL12A FLT3LG IL12B IFNG IL26 IFNA13 A2M IL23A IL22 IL-21 IL4 IL20 CSF1 IL10RA OTULIN PSMB10 PMC11640923__F5 Pathomechanisms of FTD that might involve iron imbalance UBQLN2 TAF15 FTMT FUS EWSR1 PMC3281649__F9 Proposed model for the inhibition of Notch1 signaling pathway by Fe65 HES5 NOTCH1 ITCH HES1 PMC11640923__F2 Intestinal iron absorption (left) and iron handling in a generic cell (right) MFN2 HAMP HEPH ABCB7 FTMT TFRC TF PMC7789003__F1 Synthetic view of key functional losses (−) and gains (+) during the evolution of Myzozoa COX3 COX1 FES PMC9648404__F8 Sexual dimorphism of early transcriptional reprogramming in degenerating peripheral nerves EREG EGF HGF CSF3 EGFR MAPK3 CREB1 POR CYP1A2 IFNG F2 APEX1 CYP1A1 IL1B GPER FGF2 LIF PTH TNF HRAS EDN1 NFKBIA DUSP5 ERBB2 IL3 OGT F7 RAF1 TGFB1 PMC11640923__F3 Iron homeostasis by cellular iron levels (left) and oxidative stress (right) SNCA KEAP1 SQSTM1 FTH1 FTL APP TFRC PMC8582450__F10 Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer PAK1 COPA SRC RAC1 PMC7828590__F1 ERA activity through genomic and nongenomic actions SRC SP1 TF PMC4021685__F1 Schematic simplified demonstration of the main mechanisms supposed to be involved in fatty acid and TNF family interaction at different levels of colon epithelial cell organisation TRADD TNF TRAF2 FADD IFNG PMC6132443__F2 Role of NaPiII family of sodium–phosphate cotransporters in the intestines and in the kidney FGF23 FGFR1 PTH PMC9260022__F4 ILP-2: A New Bane and Therapeutic Target for Human Cancers BCL2L1 MTOR PMC6126464__F2 The IL-6 receptor signaling pathway that is regulated by TRAF2 and TRAF5 TRAF5 TRAF2 STAT3 PMC7919195__F6 Signaling pathway network of potential AA targets HTR6 KIT ADRA2C HSP90AB1 PSEN2 FGF2 CA14 CA13 VEGFA DRD2 HRAS DRD3 ADRA2A ADRA1A HTR2A PSENEN ADRA2B CA4 HTR2B CA7 PMC8172602__F9 Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet PGP SIRT1 FASN PMC11033433__F2 Research progress on radiation resistance of cervical cancer HMGB3 EP300 SIRT4 WNT1 RAD51D NEK2 BCL2 HNF1A MTDH PMC3444627__F1 Cytokine Combination Therapy Prediction for Bone Remodeling in Tissue Engineering Based on the Intracellular Signaling Pathway RUNX2 BMP2 SMAD2 MSC PTH SMAD1 DKFZp781O1323 PMC4413642__F6 Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/Beta-catenin pathway CCND1 SRC ROBO1 SLIT2 PMC6286919__F1 Schematic representation illustrating the signaling molecules that regulate the PD-1/PD-L1 transcription APC CD80 PTEN JAK1 STAT3 PMC3886813__F1 NFKB and STAT3 signaling in glioma: targets for future therapies RELB RHD PMC11033433__F6 Research progress on radiation resistance of cervical cancer MMP7 MMP2 HDAC1 PMC3886813__F2 NFKB and STAT3 signaling in glioma: targets for future therapies OSM STAT3 PMC11033433__F7 Non-coding RNAs involved in the regulation of radiation tolerance in cervical cancer (A) the relationship between lncRNAs and radiotherapy resistance in cervical cancer YTHDF2 CXCL1 HOXB7 STYX PTEN MTOR CRKL CDK6 ELAVL1 METTL3 CDKN1A RRM2 CCND1 YY1 RAD51 PMC11033433__F4 Research progress on radiation resistance of cervical cancer ATM ZNF582 KLK5 CCNB1 PMC516236__F1 Simplified representation of molecular mechanism involved in insulin signaling pathway that regulates glucose transporter (GLUT4) translocation to cell membrane PI3 PTEN IRS1 PMC7563597__F2 Molecular mechanism of extrinsic and intrinsic pathway involved in apoptosis BAD MEI1 TRADD BMF TNF FADD BAX PMC4938032__F3 Signals shared after brain injury and in the NSC niche EGF SMAD2 FGF2 EGFR GFAP SHH SMAD4 MTOR TGFA OLIG2 PMC10153444__F2 Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders FYN SEMA3A CDK5 PMC3210456__F7 Cyclin D1 action and degradation USP2 GSK3B CCND1 PMC8232086__F1 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review MYC MTDH PMC8232086__F2 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review SUFU MDM2 EXT1 SMO PTEN MTOR ELF4 PMC11930081__F8 Proposed signaling pathway activated by oxidative stress in NHEKs FOXM1 CKAP4 EGFR TXNIP DKK1 TXN PMC7788945__F1 IL-22R downstream signal transduction pathways STAT1 TYK2 JAK1 STAT3 PMC7200337__F6 Immunology of COVID-19: Current State of the Science TLR7 TLR9 CCL2 ACE2 IL6R PMC10538627__F2 Research progress on the role of the Wnt signaling pathway in pituitary adenoma WNT4 APC GSK3B AXIN1 LRP5 LRP6 AXIN2 WIF1 PMC8723792__F3 Translational science of cancers with SWI/SNF complex aberrations ARID1B SMARCA4 FGFR1 MDM2 CDK4 EZH2 ATR CDK6 PMC3856862__F10 Therapeutic Strategies to Increase Human Beta-Cell Growth and Proliferation by Regulating mTOR and GSK-3/Beta-Catenin Pathways TSC1 IGF1 EIF4E MTOR IRS1 RHEB PMC8584977__F5 Wnt Signaling in Inner Blood–Retinal Barrier Maintenance LRP5 LRP6 FZD4 PMC4473799__F3 Targeting signaling factors for degradation, an emerging mechanism for TRAF functions TBK1 TLR4 RELA TRAF3 RELB TRAF6 IRF3 MYD88 TRAF2 MAVS MAL PMC8932066__F4 Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments CD9 CD63 CD82 CD81 PMC10538627__F1 Research progress on the role of the Wnt signaling pathway in pituitary adenoma ATF2 APC MYC AXIN1 LRP5 CYC1 LRP6 ARHA RAC1 AXIN2 CDC42 PMC9331252__F6 Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell RAC1 PCNA PMC8299464__F2 Stress Hormones: Emerging Targets in Gynecological Cancers NGF BDNF ADAM17 PMC4320218__F1 PI3K/Akt/mTOR signaling pathway ULK1 TSC1 IGF1 RHEB PMC7576747__F3 Intervention to reduce ROS for the prevention of CIN: evidence from in vitro, in vivo and clinical studies RHO MTOR SIRT1 NQO1 PMC7576747__F2 CIN via complex pathways of ROS from in vitro and in vivo studies STAT1 RHO SP1 SIRT1 PMC10571651__F1 Normal physiologic MET receptors form dimers upon HGF signaling, and Cbl binding leads to ubiquitination HGF GRB2 SRC CBL PMC8310235__F3 Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection TBK1 STAT1 CGAS STAT2 IRF9 EIF2A IRF3 TYK2 MAVS IFI16 PMC2992472__F4 The regulatory network of apoptosis in BCL11B and its related genes CREBBP ATL1-beta TNFSF10 opn BCL2L1 FADD BAX PMC8344275__F1 Deregulation of HLA-I in cancer and its central importance for immunotherapy EGFR TGFBR1 IFNGR2 IFNAR2 B2M IFNAR1 IFNGR1 IRF-1 PMC8071039__F2 Signaling pathway and cell survival BAD IMPACT JAG2 BCL2 PMC10309513__F2 Triggering receptor expressed on myeloid cells 2–apolipoprotein E signaling pathway in diseases CD9 MAFB CD33 SALL1 DKFZp686L24211 opn LPL FABP5 ITGAX CSF1 AXL GPNMB APOE CD68 CST7 BAX PMC8071039__F4 Signaling pathway and cell migration IMPACT RHO PMC4647707__F3 Differentially expressed genes in the toll-like receptor signalling pathway (ko04620) CD14 CTSK IRF7 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR3 TLR4 LBP CD40 FADD TIRAP PMC6912555__F1 Canonical and noncanonical Wnt signaling pathways ZNRF3 LEF1 RNF43 APC GSK3B PORCN TNKS RYK RHO RAC1 PMC2734294__F3 Several molecular features in the cell body of an oxidatively stressed neuron KEAP1 NQO1 PMC4647707__F4 Differentially expressed genes in the cytokine-cytokine receptor interaction pathway (ko04060) EPOR EPO FLT4 CCL21 CCL2 BMPR2 KDR CNTFR GHR CCR7 CCL25 IL9R CCL4 TNF IL23R TSLP EDAR LEP IFNK IL2RA MPL GHB2 CCR3 CCR6 IL9 IL26 IL20RA SF1 IL2 IL4 KIT BMP2 CCR4 IL24 TNLG7C PRL LTA IL3 PRLR IL6ST IL-21 FLT3 CCL23 IL20 OSM INHBB LTBR INHBA INHBE PMC3340256__F1 tBID structure and mechanism of action MTCH2 TNF PMC5707070__F8 Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARGamma-Akt signaling pathway at the early stage of carcinogenesis BAD MDM2 PTEN BAX PMC5381403__F1 Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients HERC2 KDM5B EGFR GAS7 CTR9 MYO16 SMYD1 PRKD3 RFC3 INSR PPP1R9B SMARCA4 EP300 ATM LCK ENY2 FOXG1 EZH1 ATR TTF1 INHBA PMC6901958__F1 HSV-1 mediated evasion of the DNA-sensing pathway in innate immunity TBK1 IFIT3 CH25H CGAS STAT2 IRF9 HNRNPA2B1 IRF3 TYK2 IFNAR2 LAT IFI16 PMC9405826__F7 ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells EGF MMP2 NFKB1 BCL2 PMC7472745__F5 G2/M cell cycle arrest and mechanisms by which it is affected by Vpr PLK1 ATM EME1 ATR DCAF1 PMC4171549__F2 Computational gene interaction predictions: network of E12 telencephalon-specific miRNA involved in the Neurotransmitters and other nervous system signalling pathways BACE1 CAP1 EGFR DNAJB1 TUBB2A CALM1 IKBKB ARPC3 NRP1 KCNJ2 SP1 BDNF LAMC1 GPR37 CDC42 ADCY9 PMC11670864__F1 Generation of B10 cells via in vitro stimulation of TLR pathways TLR4 TLR9 BASH TRAF3 IRF3 MYD88 CSA2 BLK PMC8503602__F3 Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms TFEB GSK3B LRP5 LRP6 BNIP3 PMC11670864__F2 BCR and CD19 signaling pathways work together to promote production of IL-10 SRC MTOR CD19 PMC7472745__F1 Replication cycle of HIV: graphical depiction of the major events of the HIV replication cycle CCR5 CXCR4 PMC10778571__F3 Pathways regulated by DKK-3: insights into DKK-3 functions DKK3 CKAP4 APC LRP5 LRP6 ROR2 PMC3843585__F2 The PI3K signaling pathway BAD MDM2 SRC PTEN RHEB PMC2757120__F1 Canonical PI3K signaling pathway TSC2 TSC1 GSK3B MYC PTEN JUN IRS1 RHEB PMC3189826__F1 p130Cas and p140Cap signalling involved in migration and invasion ERBB2 CSK SRC CRK PMC2882232__F2 Simplified representation of oncogenic signaling cascades in pancreatic cancer CCK IGF1R HGF GSKIP APC EGFR SMAD4 SRC LRP6 PTEN MTOR PMC9454979__F6 Novel Insights into miR-944 in Cancer STAT1 MACC1 EGF CISH GC SOCS4 EGFR MDM2 SRC GATA6 STAT3 PMC6036858__F1 Yeast cell cycle pathway from the KEGG database MCC CDR2 CDC20 APC ORC1L NET1 CLN3 ORC3 CIB4 ORC2 SIK1 MAL PMC6657977__F7 Circular RNA profile in liver tissue of EpCAM knockout mice IFIT2 NAIP FACL4 CAST TES IFNGR2 HNF1A PTEN MPHOSPH9 JKAMP ASB7 FAT3 CNNM3 RARA SMPD4 RICTOR LPL TNFAIP3 JUN IFIT1 SGPP2 PMC3189826__F7 Signaling pathways leading to 3D invasion of ErbB2 transformed MCF10 cells over-expressing p130Cas ERBB2 RAC1 MTOR PMC11719987__F6 Role of Notch signaling in modulating ferroptosis and its contribution to cataract formation GPX4 FTH1 SLC7A11 PMC7066404__F9 Potential mechanisms of hKLK1's protective effects on DMED SMAD2 TGFB1 BAX PMC6036858__F2 Gene network of the yeast data related to the cell cycle pathway via the JMCCM MCM3 MCM5 CDC20 MCM6 CLN3 MCM7 APC2 DBF4 ORC3 PMC3823407__F8 Proposed model of the effect of crocetin on cardiac hypertrophy, inflammation and fibrosis SMAD2 GATA4 PMC8566568__F5 RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis ACAT1 IPP ACAT2 PMC8826583__F2 Long Noncoding RNA GAS5: A New Factor Involved in Bone Diseases GDF5 RUNX2 BMP2 HDAC5 FOXC2 PMC5502539__F4 Complement factors are targets for pharmacologic inhibition in retinal disease HEL-S-62p CFD PMC5705340__F2 KEGG Ras signaling pathway with targetable nodes highlighted in red BAD DAO NOM1 LAT PMC4203564__F1 KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC RPS6KB1 CIP2A MYC EIF4EBP1 PMC9315392__F3 B-Cell in the Pathogenesis of Systemic Sclerosis IL10 PDC BCR CD22 CD40 IL6 CD80 IL1B ICOS CD19 PMC6063820__F2 Maintenance of a quiescent primordial follicle is regulated by Hippo and Akt signaling FOXO3A LATS1 RHO PTEN LATS2 PMC7807182__F6 LPS affecting glucose metabolism in cervical cancer cells through FRA1: LPS inhibits p53 by inhibiting the expression of FRA1, which regulates the levels of glycolysis and aerobic oxidation by affecting downstream GLUT1, G6PD and SCO2 COX2 SCO2 MDM2 HEL-S-133P PMC6063820__F3 Activation of a primordial follicle is regulated by Hippo and Akt signaling FOXO3A LATS1 RHO PTEN LATS2 PMC10136584__F1 WNT signaling pathways NLK DAAM1 APC LRP5 LRP6 ARHA CDC42 PMC1190355__F8 A model of IRAK1c regulation of inflammation TRAF6 IRAK4 MYD88 PMC6591252__F8 The proposed model for the scaffolding role of the IQ3 motif in IQGAP1 towards the PI3K-Akt pathway EGF EGFR IQGAP1 PMC3174148__F4 Predictive Power Estimation Algorithm (PPEA) - A New Algorithm to Reduce Overfitting for Genomic Biomarker Discovery PRMT2 TRPV2 CNP CTSH HEL-S-104 RFXAP HLA-DOA PMC3972890__F6 CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis SOCS3 CXCR4 IL22 CXCL12 STAT3 PMC10411462__F8 Function and mechanism of PARP inhibitor in thyroid cancers PARP1 RNF146 PMC8700581__F3 Senescence Alterations in Pulmonary Hypertension BMPR2 NOX4 IL6 PMC8194268__F1 Mesenchymal Stem Cell Protects Injured Renal Tubular Epithelial Cells by Regulating mTOR-Mediated Th17/Treg Axis MSC MTOR RHEB STAT3 PMC9194868__F2 Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity NAPRT NMNAT1 NMNAT2 NMNAT3 SARM1 PNP NRK HEL-S-162eP PMC8700067__F4 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease ULK1 TFEB ATG12 MTOR PMC8700067__F2 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease ULK1 ATG12 MTOR HEL-S-72p PMC8700067__F3 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease PINK1 TLR4 TBC1D15 PARK2 SQSTM1 MYD88 OPTN HEL-S-72p TIRAP PMC9170180__F1 Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs) APC ADAM10 LATS1 PMC8922216__F2 Metabolic and Signaling Roles of Ketone Bodies in Health and Disease AACS CIC ACSS2 ACLY PMC6129971__F1 Pathways of one-carbon metabolism VIT PMC7920303__F3 Metabolism of small, neutral amino acids including serine (Ser), glycine (Gly), and alanine (Ala) VIT SLC1A4 SLC25A38 PSAT1 GPT2 MPC1 SFXN1 MPC2 PSPH PHGDH SLC38A1 PMC11993586__F1 Lipid synthesis pathways and associated proteins in this review GHB3 CDS1 PC GPT2 ORM2 IDI1 PSD2 CDC2 ORM1 PMC5131952__F7 Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor ORAI1 STIM1 PMC8836921__F1 IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment LIF IL11 IL6 OSM OSMR PMC7478175__F7 The complosome in T cell homeostasis CTSL CD46 IL7R NOTCH1 PMC4767381__F2 The canonical pathway of miRNA biogenesis and the mechanisms of miRNA controlled posttranscriptional gene regulation TH AGO2 DROSHA PMC7422669__F3 Engulfment of apoptotic tumor cells induces LAP to inhibit type I IFN response and polarize tumor associated macrophages toward the immunosuppressive M2 phenotype IL1B IFNG PMC7422669__F1 Clearance processes for apoptotic cell by phagocytes rely on “find me” and “eat me” signals that signal their internalization (A) “Find me” signal: apoptotic cells release signals that attract phagocytes to the site of programmed cell death CXCR3 CX3CL1 MERTK TGFB1 PMC6563926__F1 Physiological pathways of LRRK2 activity TLR4 LRRK2 RAB10 RAB7L1 PMC6033032__F2 Schematic/pathway representation of the FOXO‐p53 interplay in cellular senescence FOXO4 ATM FOXO3A F3 FOXO1 PMC6838865__F1 Canonical and non-canonical mammalian autophagy processes ATG12 ATG101 UVRAG MTOR ATG14 PMC5026797__F1 mTORC1 re-wires GI cell metabolism upon glycolysis inhibition to promote growth and proliferation CAD PMC8483912__F3 Stingless Bee Propolis: New Insights for Anticancer Drugs EGF BAD HGF IGF1 CDKN1A CDK2 CDKN1B CCND1 PTEN CDC2 MTOR PMC11701242__F6 Molecular mechanisms of phase separation in TGFB, NFKB, and JAK-STAT pathway SMAD2 SFPQ SMAD4 TNF STAT3 PMC11701242__F7 Phase separation-mediated MAPK/ERK activation of T cell signaling pathways PLCG1 CSH2 APC LCK ZAP70 GRB2 LAT PMC9710158__F1 Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells SIRPA CD47 CCR2 BMP2 CD163 KITLG CCL2 CSF2 CSF1 CD68 PMC11701242__F4 Pathogenesis and therapeutic resistance mediated by the phase separation of the Hippo pathway TBK1 DDR1 EP300 NONO NF2 IRF3 LATS1 MED1 LATS2 MAVS MAMLD1 BRD4 PMC11701242__F5 Molecular mechanisms of phase separation in cGAS-STING-mediated innate immune responses TBK1 CGAS IRF7 TREX1 IRF3 SIRT1 PMC11701242__F3 Mechanism and activation of the Hippo pathway through phase separation AMOT LATS1 SLMAP LATS2 PMC3073741__F1 Complement and Viral Pathogenesis HEL-S-62p C9 FH C6 CR2 C4A CR1 PMC5356782__F2 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors BAD MDM2 CCND1 PTEN MTOR PMC6632497__F5 Modulating PI3K-Akt signaling pathway of SCD BAD BCR RAE1 MDM2 SYK PTEN MTOR RBL2 PMC11012486__F1 Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer PTPN21 AMOT LATS1 RHO LPA WWP1 AXL LATS2 FAT4 ITCH PMC5356782__F1 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors BAD MDM2 CCND1 PTEN MTOR PMC4449903__F1 Visualized thrombosis network VAV3 HRG MAPK4 VAV1 DAP TF VAV2 PMC9380231__F6 Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing MMP3 EDN1 ACTA2 NPAS2 PMC8766410__F3 Adenosinergic Signaling as a Key Modulator of the Glioma Microenvironment and Reactive Astrocytes ADORA2A ADORA2B ADA PMC3980079__F1 Heart Failure and Loss of Metabolic Control PC HEL-S-30 LPL CPT2 TG CD36 HEL-S-5 PMC11701242__F9 Phase separation in Notch signaling for oncogenic Myc activation and developmental fate control CCDC85C NUMB RBPJ MED1 BRD4 PMC6278416__F11 ERK/MAPK signaling pathway in liver metastasis of colorectal cancer PRKX GRB2 FLNB MAP2K6 PMC6283264__F7 The TLR pathway and let-7e target mRNAs TBK1 CD14 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 NR1C1 COX2 TLR4 CD40 CD80 NOS2 CASP8 IL1B FADD TIRAP PMC8947257__F8 Proposed model of RTK bypass pathway activation in Tpl2 -/- keratinocytes EGFR GRB2 MTOR INSR STAT3 PMC8533192__F7 Irradiation Mediates IFNA and CXCL9 Expression in Non-Small Cell Lung Cancer to Stimulate CD8+ T Cells Activity and Migration toward Tumors CXCR3 CGAS CXCL10 CXCL9 IL2 PRF1 IFNG PMC4449815__F8 Inactivation of a GAs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis YAP1 SUFU NF2 SHH SMO PMC6520835__F1 Canonical SMO-dependent HH/GLI signaling BOC SUFU GPR161 GLI3 SMO PMC6520835__F2 Genetic and molecular mechanisms conferring resistance to SMO inhibitors BOC SUFU GPR161 SMO MTOR PMC5218554__F9 Wnt Signaling Prevents the AB Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons WNT3A APC GSK3B LRP6 PMC7244035__F7 Schematic figure represented the functions of KIF23 in the Wnt/Beta-catenin signaling pathway in GC AMER1 PRC1 KIF23 APC GSK3B CCND1 PMC9355403__F8 Of ATP5MG to Treat Metabolic Syndrome-Associated Cardiovascular Diseases ATP5MG NDUFB8 HEL-S-44 COX5A MDH2 PMC6520835__F3 Therapeutic targeting of oncogenic HH/GLI signaling in cancer cells resistant to SMOi EGF SUFU APC GPR161 SMO IL6 MTOR JUN DYRK1B STAT3 HES1 BRD4 PMC6245347__F4 The miRNA-target genes involved in cancer signaling pathways HEL2 MYC PTH2 PTEN PMC6697716__F6 Putative signalling pathway of Ctyl1 CCR2 CYTL1 SOX9 PMC5228544__F1 Roles of TBX2 and TBX3 in tumorigenesis and tumor progression PML EGR1 TBX2 TBX3 MDM2 PIWIL1 PTEN PSCA CDH2 AKT3 PMC3505266__F3 Heterogeneity in the differentiation and function of memory B cells BCR IL-21 PMC3959597__F7 Cross talk between metformin, androgens, and IGF system and molecular mechanisms of metformin inhibitory effects SRC MTOR PMC9632889__F10 Potential mechanism of the effects of leonurine attenuating cardiac fibrosis in heart failure COL3A1 SMAD2 GSDMD PMC7350219__F1 Cytosolic DNA sensing and pathway activation TBK1 CGAS TRAF6 IRF3 PMC4080180__F12 Current understanding of LPA/LPA5R stimulation of NHE3 activity and mobility based on current studies and the previous reports from the laboratory of Yun and colleagues (, ) NHERF2 EGFR RHO LPA PMC4636730__F2 Proposed schematic of intracellular immune response to murine norovirus (MNV) infection STAT1 ISG15 IRF7 IRF3 PMC3359223__F1 Glycolysis metabolic pathway HEL-S-49 ENO2 DLD PGAM1 HEL-S-68p HEL-S-162eP PMC2136409__F8A Genetic and epigenetic mechanisms of gene regulation during lens development SOX2 EYA1 CDK2 FOXE3 SIX3 BMP7 CDH2 BMP4 HES1 PMC7282943__F1 Transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas SMAD2 TGFBR1 SMAD4 TRAF6 RHO TRAF4 PMC7161743__F2 Leishmania heme auxotrophy FECH UROD UROS CPOX PMC9120235__F4 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization MAP2K4 TRADD MADD MYD88 MAP2K3 TNF MAP3K7IP1 MAP2K6 TNFSF11 SRC CD40 CD40LG FADD TIRAP PMC9120235__F5 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization PMM1 GMPPB PMC11343602__F8 Schematic diagram illustrating the mechanism and intervention strategies of the IL-27/Blimp-1 axis in regulating Tim-3 expression on Tregs STAT1 TIGIT STAT3 PMC6469996__F6 Pathways regulated by NNMT and proposed working model of mechanisms of action of NNMT inhibition as it relates to muSC activation and metabolic state in aged muscle tissue AOX1 NAMPT NNMT SIRT1 NRK PMC3996895__F1 Biogenesis of canonical and mirtron miRNAs in animal cells DGCR8 DROSHA RAN PMC6669816__F8 Mechanism by which eucalyptol protects APAP induced liver injury KEAP1 APP CYP2E1 PMC3996895__F2 Canonical NFKB signaling network regulated by miRNAs CYLD MYD88 PMC5504484__F4 Signaling pathways assigned to the Ingenuity Pathway Analysis (IPA) category “molecular mechanisms of cancer” that have been linked to ovarian cancer and targeted by epigallocatechin‐3‐gallate (EGCG) BAD BRAF DAO APC MYC CRK IRS1 LEF1 MAX SUFU GRB2 CCND1 SMO JUN RBL1 BAX PMC3383335__F1 SnoN Signaling in Proliferating Cells and Postmitotic Neurons PIAS1 PMC7600388__F1 Summary of hepatic lipid metabolism pathways altered in NAFLD and driving dyslipidemia PNPLA3 FGF21 ANGPTL3 PCSK9 LDLR ANGPTL8 TG NR1C1 FASN PMC4400057__F3 NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation EGFR CACNA2D3 PMC3797786__F3 Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells ENTPD6 ACACA UCK2 UMPS NME3 GAA CYP27A1 FECH CANT1 PARS2 RRM2 FARS2 APOBEC1 HEL-S-304 NME4 GPD2 TPMT ENTPD5 PFKP SMS ADK PYCR2 GNE MCEE NDUFB2 PCCA PCMT1 TK1 PRKCB ACADL FARSB SMOX ASNS PRODH DHFR ADA APRT AK1 PMC9465159__F1 Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy CGAS IRF7 IRAK1 IRAK2 TRAF3 SSB PARP1 IRAK4 IRF3 IL6 MYD88 TNF WEE1 ATM IL4 ATR IL1B MAVS PMC5955808__F1 Colorectal cancer prevention: immune modulation taking the stage BRAF APC CTLA4 PMC2924553__F1 BMP signal transduction NLK SMAD4 SKI SMAD1 DKFZp781O1323 PMC5674651__F2 Homocysteine metabolic pathway HEL-S-61p MTR PMC8129370__F3 Value of miRNAs in the prognosis of obese patients receiving bariatric surgery FOXO3A ADAM17 PMC7760708__F6 Top two signaling pathways regulated by miR-215-5p in CRC CD47 VASP FYN HEL-S-28 CD44 VWF CHAD ARHA PTEN DMP1 JUN CD36 PMC8951629__F2 Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin TBK1 IRF7 TRAF3 TRAF6 IRF3 MYD88 TRIM25 MAVS PMC4361049__F1 A stepwise demonstration of the hepatitis C virus internal ribosome entry site (HCV IRES) translation initiation pathway ELF2 EIF5B IL1A ELF3 EIF2D EIF2A PMC8085490__F5 Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma MYC ACSS2 UCP2 MDH2 SIRT3 GOT2 SIRT4 SIRT5 PDHA1 NDUFA9 HEL-S-44 SBNO1 RSMC PCK2 PGAM2 BAX FOXO3A OTC PFKL TINCR ACADL CDH4 STK11 SUCLG1 MLYCD ACLY CP GLS HIST1H2BE PMC9454445__F2 Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer NAPRT NAMPT HEL-S-90n NADK NRK PMC3170128__F5 Innate and adaptive immune responses to cell death NLRP3 HMGB1 TXNIP PMC3164983__F1 mTOR inhibitors in renal cell carcinoma TSC2 RICTOR TSC1 EIF4E MTOR RHEB PMC4381889__F4 KRAS-reprogrammed glutamine metabolism in pancreatic cancer.Notes: In KRAS-mutant pancreatic cancer, mitochondrial glutamine flux is reprogrammed to predominantly flux through GOT2, instead of the canonical GLUD1 pathway ME1 ME2 GOT2 GLUD1 HEL-S-32 PMC11897528__F2 Lipid metabolism in GBM cells EGFR LDLR ELOVL2 PMC4818529__F1 The comparison of different biosynthetic pathways for propane production HBD PMC5344790__F1 Metabolic interactions with cancer epigenetics HEL-S-61p MTAP HEL-S-182mP NNMT PEMT PMC6477784__F1 The inflammasome as a gear or cogwheel that couples purinergic signaling with the complement cascade (ComC) in the process of HSPC mobilization HMGB1 IL1B PMC4381889__F1 NADPH production from the oxidative PPP and one-carbon serine catabolism pathway.Notes: Oxidative PPP uses glucose to generate NADPH via G6PD and 6PGD TIGAR NAMPT NADK PMC7838852__F1 Diversity and versatility of p38 kinase signalling in health and disease ZAP70 MAP3K7IP1 MAP2K6 PMC7838852__F3 Diversity and versatility of p38 kinase signalling in health and disease FGF21 ULK1 UCP1 RUNX2 PAX7 NELFE IFNG RIPK1 ZC3H10 CCND1 EZH2 RBM7 IL1B RUNX1 LAMP2 GFAP DROSHA GADD45A DLX5 HNRNPA0 TNF IFNAR1 IGF1 CDKN1A SOX10 PMC6477784__F3 The interplay between purinergic signaling and ComC activation during mobilization of HSPCs HMGB1 PLCB2 S100A9 PMC11897528__F5 Double-edged sword of metabolic reprogramming in GBM, showing the balance between resistance mechanisms and therapeutic vulnerability GPX4 LCN2 RELB IMPDH2 ABCA1 HK2 FASN PMC8306223__F2 Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma SETDB1 SMAD2 ANXA2 FOSB HEL-S-44 APOE PMC11936992__F3 AMPK regulates the mechanism of action of FNIP1 TSC2 FLCN TFEB FNIP1 OPTN RHEB PMC11936992__F5 Interaction of FNIP1 with autophagy CCL8 FNIP1 TCF12 MYOG MYH7B PMC11936992__F6 Action of FNIP1 in causing cancer TSC2 FLCN TSC1 TFEB STAT2 FNIP2 EGFR FNIP1 RHO RHEB PMC6271242__F1 The PI3K signaling pathway and sides of action PI3K/Akt/mTOR pathway inhibitors RICTOR CARD11 BCL10 BCR PTEN MLST8 PMC5523860__F7 HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development SNAI1 HNRNPAB TWIST1 MSX1 HAS2 HAND2 SOX9 PMC8617296__F9 Quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus EGFR MAPK3 VEGFA TNF JUN PMC12077450__F2 CysLTs in lung injury HMGB1 EPX MBP IL33 IL25 TNF PMC4338749__F1 Drugs that inhibit folding or disposal of misfolded proteins PMC8581318__F10 SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/B‐catenin pathway APC CCND1 PMC6480217__F7 Hypothetical scheme of CA action in mammalian cells AKR1B10 NGF KEAP1 ATF4 ASNS EIF2A TRIB3 PMC4197569__F2 Proposed model for autophagy that implicates PLD PLD2 MTOR PMC7442051__F1 Mechanism of autophagy ULK1 ATG12 MTOR BNIP1 DKFZp686F0183 PMC6742496__F7 Proposed Model - LPCAT1 Links Genetic Alterations of Key Components of the Growth Factor Receptor Machinery with Plasma Membrane Remodeling to Drive Tumor Growth, Generating an Actionable Dependency across Cancers PC EGFR LPCAT1 PMC7442051__F2 Figure depicts the autophagy regulators in regard to lung injury EGR1 ATG12 ATG3 MTOR BNIP1 ATG14 DKFZp686F0183 PMC3934442__F5 Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis ROCK2 ROCK1 FHL2 ARHA PMC2633249__F3 Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases BAD AMFR RAC1 PMC9068331__F2 Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability TRIL KIT RHO PTEN DEPTOR RHEB PMC9675141__F6 Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NFKB pathway COX1 KEAP1 BAX PMC5118085__F1 Notch signaling and alloreactivity NOTCH2 NOTCH4 NOTCH1 ADAM10 NOTCH3 PMC9032508__F6 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia HEL-S-62p HEL-S-133P PMC3365799__F13 Major steroidogenic pathways in the three zones of the human adrenal cortex PAPSS2 SULT2A1 POR PMC5089941__F1 Mechanism of appetite regulation by the hypothalamus and peripheral tissues CCK POMC NPY CRH AgRP MC4R TRH PYY PMC3660828__F3 Components involved in translocation of phospholipids to and within mitochondria of yeast PGS1 CDS1 PC PGP ATP23 PHB2 PMC9032508__F2 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia TSC2 ATM HIF1A PMC12154365__F6 Dual functions of EBF1 and its molecular regulatory network across multiple tumor types SOX2 HEY2 G3BP2 FBN1 PMC3383335__F2 SnoN Signaling in Proliferating Cells and Postmitotic Neurons APC FOXO1 PMC12154365__F4 EBF1-mediated oncogenic mechanisms and regulatory network in BCa NR2F1 RBP7 PMC6521028__F8 Mechanism of PDCoV N protein interfered with the type I IFN response STAT2 IRF7 TRAF3 IRF3 JAK1 MAVS HEL-S-69p PMC2936760__F5 Signaling pathways described in ARPE19 cells CD36 PMC6500894__F2 Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword MSC NTS TNFAIP2 PMC3660828__F2 Biosynthetic pathways of aminoglycerophospholipids PC PSD PEMT PMC4002809__F2 Current model for NFKB signaling pathway induced by C-type lectin receptors CARD9 SAP130 BCL10 SYK PLCG2 PMC8346978__F2 Molecular Pathogenesis of Psoriasis and Biomarkers Reflecting Disease Activity NLRP3 CCR2 ATM CCL2 TNF PMC270001__F2 Chemoresistance in Human Ovarian Cancer Cells MDM2 CDK4 CDK6 BAX PMC2907250__F1 The three top ranked pathways in this study.‘Syndecan-1-mediated signaling events’ from PID; (B) ‘Signaling of hepatocyte growth factor (c-Met)’ from BioCarta; (C) ‘Growth hormone signaling pathways’ from BioCarta HGF CASK GRB2 PTPN11 hEMMPRIN PTEN HRAS TG HPSE CRK JUN PMC7016889__F1 General view of glycolysis WAS HEL-S-87p PGAM1 HEL-S-68p HEL-S-162eP PMC3729218__F4 Mutations causing susceptibility to intestinal inflammation EREG AQP3 TLR9 AREG EGFR MUC2 XBP1 YIPF6 PMC8997157__F4 PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression PTEN CDC42 PMC6186653__F2 Schematic diagram showing both the pathway for VEGF upregulation though EGFR/ALK gene alteration and its immunosuppressive role ALK EGFR MTOR PMC10377462__F10 Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment HRH1 MMP3 EGF TGM3 MAPK8 YBX1 F2 MAPK3 MAPK14 ADRB2 BCL2L11 CDKN2A PMC6016172__F2 Pathway linked to ER stress ATF4 IRS1 PMC11063913__F1 Regulatory mechanisms of cytokines in male sex determination in mice AMH SF1 DMRT1 WT1 SOX8 GATA4 SOX9 FGF9 SRY PMC12059313__F8 Isobutyrate confers resistance to inflammatory bowel disease through host–microbiota interactions in pigs NLRP3 AHR PIGS MYD88 FOXP3 PMC2833311__F6 Signaling pathways involved in Alpha-TEA-induced apoptosis in human ovarian cancer cell lines ERBB2 ERBB3 BAX PMC6471306__F1 Type I and III interferon production following pathogen sensing STAT1 STAT2 IRF7 IRF9 IRF3 IFNAR2 IFNAR1 IFNLR1 PMC3292751__F3 Regulation of mammalian mitophagy MFN1 MFN2 PARL OPA1 PMC4249724__F4 Müller glia cell reprogramming and retina regeneration IGF1 HBEGF STAT3 PMC317036__F5 Model showing the possible relationship of dTOR with the insulin pathway PTEN EIF4E PMC4490668__F1 Multifactorial pathogenesis of primary Sjögren’s syndrome: interferons as culprits in the self-amplifying pathogenic loop TH PDC TLR7 RO60 SSB PMC11063913__F2 Regulatory mechanisms of WT1 in sex differentiation AMH SF1 RHO WT1 SOX9 CDC42 PMC11063913__F4 Regulatory mechanisms of SOX9 in sex differentiation SOX9 FGF9 SRY PMC8076851__F4 Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice TAS1R3 PLCB2 LEP POMC FFAR3 LEPR FFAR2 FFAR1 TRPM5 TAS1R2 CD36 PMC11063913__F5 Graphical summary During sex determination in the male embryo, the expression of numerous cytokines at specific times and spaces act together to regulate the lineage differentiation of Sertoli cells AMH PGC SF1 DMRT1 WT1 GATA4 SOX9 FGF9 SRY PMC9587054__F4 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions CXXC5 ADD1 UCP1 NOTUM LRP5 LRP6 ARHA RYK OSBPL2 STAT3 PMC9603842__F4 Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review CASP3 CASP8 FADD STAT3 PMC9587054__F5 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions POMC NPY UCP1 AgRP HEL-S-104 SIRT1 BMP4 FASN PMC6909968__F6 Proposed schematic model illustrating the role of SLCO4A1-AS1 in regulating CRC by EGFR/MAPK signaling pathway MAP3K1 BRAF EGFR PMC9587054__F6 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions CCK POMC NPY AgRP MC4R MC3R MC2R PYY ARC PMC11628531__F1 LAG-3 signaling pathway and its ligands in tumor immunity APC ADAM10 LAG3 FGL1 ADAM17 PMC9587054__F3 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions RET POMC NPY UCP1 ALK GDF15 AgRP PGC pp6425 GFRAL ADRB3 GDF3 PMC9243884__F3 IL-1 family of cytokines and receptors in pathogenesis of COVID-19 IL33 COPA PMC9256571__F1 Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease CXCR3 CCR5 CXCL16 CCR6 CXCL10 CCL20 CCR4 CXCL9 CCL25 CCL22 CXCR6 CXCL11 PMC4078240__F4 Map of SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis INSIG1 SCD ACSS1 FDPS ACACA ELOVL3 ACACB GSK3B HMGCS1 ACLY GPAM FASN PMC8301368__F7 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway GSK3B BRCA1 PMC8301368__F8 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway MMP2 MMP9 GSK3B SRC ARHA PMC8648465__F7 Network Pharmacology-Based Analysis of the Underlying Mechanism of Hyssopus cuspidatus Boriss. for Antiasthma: A Characteristic Medicinal Material in Xinjiang MAX TRADD TNF C13orf34 JUN MX1 PMC7003858__F4 Signaling in T‐cell activation and PD‐1–mediated suppression ITK APC LCK ZAP70 PMC9298327__F1 Expression, prognostic significance and therapeutic implications of PD‐L1 in gliomas APC ZAP70 CD80 PTEN LAG3 PMC6621970__F10 Schematic highlighting the signaling cascades that are dependent on erbB4 in MPNSTs ERBB4 GRB2 NRG1 RAF1 SOS1 MTOR STAT3 PMC3718675__F3 Axis of ageing: telomeres, p53 and mitochondria IGF1 FES MTOR SIRT1 PMC3524155__F1 Sensing the enemy NOD1 NOD2 PMC8099789__F1 ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients PLG ATR ACE2 ADAM17 PMC2594010__F2 Regulation of metastasis in colorectal adenocarcinoma: A collision between development and tumor biology APC WNT1 GSK3B MYC CCND1 PMC3932427__F1 Schematic showing the interference of Hepatitis C virus in the insulin signaling pathway TSC2 TSC1 SOCS3 MTOR RHEB PMC5367255__F8 Model depicting role of miR-432 in regulating myogenesis MTOR E2F3 MYOG PMC7922006__F8 CASR-ROCK-YAP1 signaling pathway in tumor parathyroid cells CASR YAP1 ARHA LATS1 LATS2 PMC3131157__F6 Manipulation of plant cell ubiquitin pathway by bacterial pathogens BAK1 CERK PMC6652118__F1 RIG-I/MDA5 signaling pathway RIG-I and MDA5 are first activated by recognition of PAMP dsRNA, which causes them to interact with MAVS TBK1 IRF7 IRAK1 IRF3 MAVS PMC9520222__AF1 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway COL3A1 COL6A1 COL1A1 SOX9 CDC42 PMC7317989__F1 Model illustrating the steps of EBV infection of epithelial cells NRP1 CR2 EPHA2 PMC7553088__F4 Chemokine-like factor 1: A promising therapeutic target in human diseases VCAM1 CCR4 BAX PMC7553088__F5 Chemokine-like factor 1: A promising therapeutic target in human diseases MYC CCR4 CCND1 STAT3 PMC6886211__F8 PLNet2: LocPL pathway reconstructions (first 100 paths) EPOR IGF1R ATF2 EGFR TRIP10 FGFR2 BTK FYN HGS PTPN11 APP SRC CDC27 IL2 LEPR NMI KIT c-fgr FOXO3A NR3C1 CBL LYN JAK3 SYK TYK2 JAK1 RAF1 SHC1 STAT3 ITCH PMC9409040__F7 Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer PPP5C ATM E4F1 ATR CHEK1 DLAT PMC2153443__F8 TGFB SIGNALING BY PROINFLAMMATORY CYTOKINES IN ARTICULAR CHONDROCYTES IL1B TF PMC7154099__F1 Schematic diagram depicting the regulation of osteoblastic-specific genes expression by lithium through activation of three major signaling pathways, including the canonical Wnt/Beta-catenin, PI3K/Akt and BMP-2 signaling pathways RUNX2 NFATC1 APC SOST GSK3B LRP5 LRP6 SMAD1 DKFZp781O1323 PMC8394324__F3 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer APAF1 MCL1 TNF FADD BAX PMC7228650__F2 Epigenetics of colorectal cancer: biomarker and therapeutic potential MMP7 EGF SMAD2 APC EGFR MYC LRP5 SMAD4 PTEN HIF1A PMC8394324__F4 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer TSC2 TSC1 PTEN RHEB PMC10987302__F1 Crosstalk between lncRNAs and Wnt/Beta-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response HMGB1 WNT2B AXIN2 SOX4 PMC4522946__F6 Apoptotic signaling pathway induced by Licochalcone-A in head and neck squamous carcinoma FaDu cells BAD BCL2 FADD BAX PMC10487929__F9 Network connectivity pathway map of the downstream effects of simulated SARS-CoV-2 infection on the predicted activity of the NISP STAT1 SNCA HLA-DRB5 IRF7 PTGS2 CCL5 IL6 CCL2 TNF ACE2 IL1B IFNG PMC4447643__F9 Schematic diagram showing the modulation of insulin-mediated glucose uptake in muscle cells by CRFR2 signaling pathway MTOR IRS1 PMC4238866__F10 Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae RRN3 MAF1 PMC4298491__F2 PI3K in the biology of B cells BTK BCR LYN CXCR5 CD40 SYK PLCG2 MTOR CD79B CD19 PMC4298491__F3 Signalling of the PI3K/AKT/mTOR pathway and relevant drugs that target each of the components of the pathway BCR EGFR PTEN PMC10487929__F6 Influence of COVID-19 on SNCA expression and PD PLSCR1 CCL5 CCL2 CD74 MX1 IFNG STAT1 ISG15 RBP4 SYN1 ACE2 NTRK2 EMP1 IL1B SNCA AIP CHL1 RSAD2 IRF7 SYN2 PTGS2 IL6 TNF ID1 CHRNA6 CCK RET TREM1 PMC10487929__F7 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD SNCA CCL5 ACE2 IL1B IFNG PMC10545783__F1 Bacterial PSAs transduce signals through innate receptors to modulate immune responses TLR4 IRF3 MYD88 TLR1 PMC8073160__F4 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review FGF23 RUNX2 BMP2 SOST FGF2 PMC8073160__F1 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review SOST MSC PTH TNF PMC4710174__F1 HSC aging and senescent immune remodeling SATB1 CXCL12 CDC42 PMC2151350__F2 Model for renal pathology in Dent's disease (due to a loss of ClC-5) The small peptide PTH (parathyroid hormone) and various forms of vitamin D (VitD; bound to their binding protein) pass the glomerular filter into the early proximal tubule (A) NR1i1 TRPV5 PTH PMC6623175__F9 Model proposed to explain why BDNF fails to regulate local translation in the hippocampus of Ts1Cje mice LIMK1 FYN HOMER2 PLG ARC EIF4E MTOR BDNF DSCAM PMC9692093__F2 RNA modification in the generation of acquired drug resistance in glioma ZNRF3 ADAR SOX21 GM2A IGF2BP3 MYC GSC EZH2 PMC4704338__F1 Activation of the Notch signaling pathway EGF IGF1R PMC2649208__F2 Molecular interaction map displaying the functional interaction of genes in the MEK/ERK output profile with established roles in ERK signaling DUSP4 EGR1 PLK3 SPRY4 FOSL1 FOS ETV4 MYC SPRY2 CBL IER3 GRB2 CCND1 ETV5 PMC6966515__F2 Schematic showing the numerous cellular events which are altered by viral proteins in transformed cells (see key bottom right corner) CDC20 APC RHO MTOR FADD CDC42 PMC1599931__F1 Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway EIF4E RHEB PMC3228224__F1 Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA TSC2 TSC1 MTOR PMC4793911__F2 Major cellular mechanisms controlling contraction in gastrointestinal smooth muscle cells GCA NACA2 ARHA GAA PMC9505944__F2 Controversial Role of LPS in Platelet Activation In Vitro CD14 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC514817__F2 Cytokine production by MAPK pathways GCK JUN CDC42 PMC9505944__F3 Controversial Role of LPS in Platelet Activation In Vitro CD14 TLR4 IRAK1 IRAK2 IRAK4 MYD88 TIRAP PMC7919585__F2 CoVs on mitochondrial dynamics and autophagy as a quality control axis and the regulatory effect of melatonin.Coronaviruses impacts mitochondrial dynamics and mitophagy PINK1 ATG12 ATG3 ATG10 DIABLO ATG14 DKFZp686F0183 HTRA2 FIS1 OPA1 BAX PMC8316339__F5 Apicoplast isoprenoid biosynthesis is critical for P. falciparum survival of febrile temperatures RAB5C IPP RAB11B PMC514817__F4 Interaction of stress and inflammatory responses FOS IL6 HSF1 JUN PMC4488779__F2 Proposed model of the vitamin D-dependent antimicrobial pathway NR1i1 HAMP DBP CD40 TLR1 NOD2 PMC8957809__F8 Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3Beta-Mediated Keap1/Nrf2/HO-1 Signalling Pathway GPX4 KEAP1 GSK3B PMC5435544__F4A Signal transduction pathways and targets in paediatric Burkitt lymphoma MAPKAPK2 MAPK9 IL1A IRAK1 MAP3K7 TRAF6 IRAK4 IFNAR2 IFNAR1 HEL-S-31 STAT1 IKBKB NFKBIA TNFSF6 MAP2K1 TNFRSF1A APP CD80 MAPKAPK3 RAF1 MAPK11 PMC7905385__F1B Immune response, immunopathology, and mechanism of action of immunotherapeutics for SARS-CoV-2 infection (intracellular) COX2 TLR7 TLR9 AAK1 HEL-S-11 CXCL2 IL1B TLR3 TMPRSS2 PMC6014315__F1 Impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment TSC2 TSC1 PTEN INPP4B PMC11121230__F2 SHIP1 and SHIP2 in the PI3K/AKT signaling pathway (created with BioRender TSC2 TSC1 PTEN PDPK1 RHEB PMC5929164__F5 Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis NF2 LATS1 NEDD8 LATS2 PMC3060878__F5 FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways FGF21 CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 CYP7A1 PMC8125511__F5 Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production TBK1 STAT1 STAT2 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 PMC8615865__F3 Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment RAC1 PMC4839647__F3 A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer SDHC CS ACACA AMD1 SMOX ACACB SRM ACO2 SUCLA2 ACLY SUCLG2 SDHD SMS SDHA FASN PMC6924635__F1 Exosome biogenesis and major exosomal cargoes CD9 CD63 RAB27A CD82 RAB27B CD81 PMC7563377__F8 Model illustrates targeting of the hedgehog (Hh) signaling using PSMA aptamer conjugated PBM-NPs inhibits prostate cancer tumorigenesis SUFU PTCH1 SHH SMO PMC4222901__F2 Cytoskeletal modulation and signaling EGFR AHNAK RAC1 ARF6 TARP CDC42 NCK1 VAV2 PMC7364818__F7 Differentially expressed genes in the PAI-1 KO injured tendon that contribute to the activation of the canonical PTEN Signaling pathway at 2-weeks post injury CASP3 BAD MAST2 PTEN PREX2 PMC9279758__F6 CD44 potentiates hepatocellular carcinoma migration and extrahepatic metastases via the AKT/ERK signaling CXCR4 axis CXCR4 CD44 CXCL12 PMC4539069__F1 Proposed model for the complex cross talk between various receptors and mediators in early phase response in allergic rhinitis CCR2 NGF CCR3 TRPV1 PMC3693108__F1 Therapeutic molecular targets for endometrial cancer EGFR PTEN MTOR FGFR2 PMC6077868__F7 TGFB-dependent signaling implicated in fibrosis process ARHA SPHK1 MTOR PMC3162305__F4 Oncostatin M signaling pathway MT2A TIMP3 GRB2 OSM OSMR PMC2533092__F1 Metabolic pathways for the synthesis of phospholipids and neutral lipid classes in S CDS1 PC GPT2 PMC3648340__F1 Iron and Diabetes Risk HEPH FES HFE TF TFR2 PMC3571654__F1 shows the effects of osteoblast-secreted osteocalcin on glucose homeostasis and its novel role in regulating testosterone production in the leydig cells RUNX2 ATF4 CYP11A1 STAR PMC6034278__F5 LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs IFI44 OAS2 TREM1 IRF7 PTX3 PMC126023__F7 Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae RAD1 OGG1 PMC3258305__F2 The Long History of Iron in the Universe and in Health and Disease STEAP3 ABCB7 TF PMC11003173__F10 Hypothetical modules and cold response pathways of eggplant MYB ERF CBL PMC9086029__F6 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma CRY2 MAPK14 WAS ZNF460 NBPF10 PACS2 TCF23 ATXN2L ANP32B CHRM2 UGT2A1 CHMP3 LSM11 ZBTB18 CCT4 MYZAP YAF2 ARL11 DNPEP VAT1 CMBL BACE2 CFL2 DOHH COL1A1 INMT CELF2 B4GALT1 ZER1 BTN3A3 ANTXR2 AKAP8 CDH8 METTL15 ZNF488 TMEM178B FNBP1 VPS37A TSPAN1 TMEM170A DNAJB9 HUWE1 CYP2A7 SLC25A17 C10orf67 SREK1 EXOC5 ZNF610 MAGEB4 ZNF277 NWD1 SIRPA TRIM13 HMGXB4 GPR75 ZNF429 EGLN3 XRRA1 ARSK RBBP9 TRIB1 ATP9A RRP7A ARHGEF33 TMEM184A TXNIP PKDREJ LHFPL2 CD226 FBXL16 OCIAD2 AAR2 HNRNPA1L2 FRMD6 SP9 PMC9086029__F7 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma PTGER2 ZNF730 RPL17-C18orf32 PQBP1 FOXM1 SAE1 MYD88 MTOR GPC1 DVL2 CDH2 SP1 NFYB ZBTB2 WNT9B NTRK3 UST HUWE1 IL6 CREBBP MAT1A ARPC2 BBC3 SCAMP3 WNT2B SLC40A1 ZNF783 PMC3651307__F1 Toll-like Receptor (TLR) Signaling Pathways TLR5 IKBKE TLR9 IRF7 IRAK1 TICAM2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TICAM1 TLR8 TLR7 TLR4 TIRAP PMC5901872__F2 Expression difference of metabolic genes between the GX stage and X stage in BSGX001 and XH7 COX17 ACO2 COX10 COX5A HEL-S-4 PMC3792371__F1 TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma TH ITK FYN LCK ZAP70 DLD IL4 IFNG PMC9183106__F6 Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway MDM2 BCL2 BAX PMC8505060__F9 Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway CORT CRH BDNF PMC4766714__F9 Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice HEL-S-62p CD14 CD133 AHRR EHF HEL-S-25 CXCL5 PF4 LCN2 CXCL2 TNF ELF3 CCL20 CXCL17 CCL28 CCL22 CP PMC3185763__F1 Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) pathways that lead to apoptosis of HIV infected helper T cells CXCR4 FADD BAX PMC442148__F2 Protein interaction map around some selected baits in the TGFB pathway PIG59 LAPTM5 RNF11 PSG2 NCOR1 FLNA SMAD2 SMAD4 PPP2R1A SOX7 EEF1G RPS27A SOX13 SNIP1 ETS2 SKI SP1 NUP155 GOLGB1 DAZAP2 PPL SMURF1 FAF1 ST13 CANX PPP1CC SMURF2 ERBIN DKFZp781O1323 TRAF4 PMC4589430__F2 Immunosuppressive and tumor-promoting functions of TAMs and MDSCs in HCC CD14 CD33 CD163 CD68 STAT3 PMC5596246__F1 Caspases in extrinsic and intrinsic apoptosis TRADD APAF1 FADD BAX PMC5596246__F3 Caspases control the cGAS-STING signaling pathway TBK1 CGAS IRF3 BAX PMC5596246__F4 Caspases regulate RLR and TLR antiviral signaling TBK1 TLR9 TRADD IRF7 RIPK3 IRF3 MYD88 TRIM25 TLR3 TLR8 RIPK1 TLR7 FADD MAVS PMC6245571__F2 Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages SPR PTS SLC7A1 ARG2 OTC SLC3A2 ARG1 ASS1 TASL ASL PMC7411521__F4 Apoptotic signaling through membrane (lipids)-mediated spontaneous activation of Bax/Bak CASP3 BAD BIK CASP9 BMF CASP8 FADD HRK BAX PMC3056121__F1 Regulatory natural autoantibodies to apoptotic cells: Pallbearers and protectors TLR7 PC TLR9 ACR PMC8878972__F7 Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease PARP14 PLSCR1 PLCB3 ACOT13 CXCL8 APOD MTMR2 SERP1 DCN OAS1 PLA2G12A SLC2A3 MANBA COL2A1 PGAM1 SLC39A14 FGF7 GNS HEL-S-30 FOXO3A CD44 GYS1 HEL-S-87p HAS2 HEL-S-68p LYN ST3GAL1 CSF1 FABP1 PMC2919952__F1 Scheme of basic metabolic pathways and energy conservation in C TH PTS ETFB ETFA PMC6589702__F8 Proposed model of regulation of endothelial barrier function by FBXW7 SQLE LDLR FBXW7 RHOB HMGCR PMC10502988__F8 Following CARNIVAL analysis (or re-uploading previous results) the user can carry out pathway enrichment and visualisation on the inferred signalling network PIK3CD EGR1 FOXO4 SOX2 FOXO3A EGFR MAPK3 CREB1 NR2F1 HSF1 FOXO1 RARA RET ERBB4 MAP2K1 EP300 MAX SPI1 NR2F6 ERBB2 RELA ZBTB16 SREBF2 PIK3CA PMC5932261__F7 Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells HEL-S-28 ARHA PMC7308544__F2 The metabolic interrelationships between low-density lipoprotein (LDL) subfractions and their hepatic precursors APOB LPL TG PMC5522095__F8 Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer’s disease NLRP3 TLR4 CGA PMC9084694__F4 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes ST7 CDKN2D CHODL CD63 ARHGAP30 RBM4B TMCC3 ID3 FGFR2 HEL-S-22 ACSL5 LRAT SMARCA4 TUBA2 MYH4 CDKN1A TMEM171 TYRP1 IL15RA EPHB2 PMC5243144__F4 Schematic summary of metabolic pathways disturbance caused by suppression of pyruvate carboxylase in MDA-MB-231-derived cell lines ME1 HEL-S-26 PC GLS PMC6165719__F1 Signaling pathways underlying synaptic plasticity in striatal direct pathway spiny projection neuron PDE1B PC CDK5 PMC9084694__F2 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes VASP GIG8 H1-2 H2AC20 MNX1 NOS2 HIF1A PMC11276987__F10 Lipids as signaling molecules that regulate metabolism TLR4 SRC IRF3 MYD88 MAP3K7IP1 IRS1 PMC7418812__F9 Model for glucose regulation ovarian primordial follicles activation via the AMPK/mTOR signaling pathway LATS1 MTOR PMC4179923__F6 Tazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathway FADD PMC2954288__F10 Hypothetical model for SWAP-70 function in mast cell FcERI signaling IL4 LAT PMC5774249__F8 Cellular model of insulin (and leptin) signaling via TRPC5 channel activation in POMC neurons POMC SOCS3 TRPC5 STIM1 PMC3670000__F2 Signaling pathways used by GH to regulate growth and metabolism STAT1 GRB2 SRC MTOR STAT3 PMC3670000__F3 Signaling pathways activated by E2 and its crosstalk with GH SOCS2 GHR PMC4933215__F2A Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities PIK3CD PIK3R1 IGF1R PLCG2 TFRC HIF1A EIF4EBP1 MTOR IFNG TLR4 RPS6 CAMK2D CDKN1B VHL VEGFA CAMK2G EIF4E RBX1 PIK3R3 CREBBP MAP2K1 CDKN1A ERBB2 NFKB1 BCL2 PIK3R2 PMC10948231__F2 PPARG and the PTEN-PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma PIK3CA PTEN PPARG AKT3 PMC5249061__F6 A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma RIDA SMURF2 MYC JUN HEL-S-162eP PMC6770393__F2 Key metabolic remodeling and potential therapeutic targets in glioblastoma (GBM) TES EGFR MYC ACSS2 PTEN MTOR BCAT1 PFKP HEL-S-133P HK2 GLUD1 HEL-S-281 GLS PMC5253647__F6 SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers SMARCA4 HCTP4 AURKA PMC7550790__F1 Involvement of unfolded protein response (UPR) in neuropsychiatric disorders EIF2A BDNF XBP1 PMC2998292__F1 Estrogen and Tamoxifen Metabolic Pathways depicted at the genomic level CYP2B6 CYP1B1 PGR CYP3A4 CYP17A1 PMC3851681__F1 Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection EBI3 IL23R IL12RB1 PMC2998292__F2 Pathway Analysis Models for the Tamoxifen (TAM) Pathway tested with data from the Placebo (P) and Tamoxifen (T) arms CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC6246015__F2 Signaling pathways subverted in T-cell oncogenesis VAV1 MYC ARHA RAC1 MTOR CARD11 FYN BCL10 RELA LCK ZAP70 GRB2 BCL2 PTPN6 JAK1 LAT ICOS STAT3 PMC9696358__F2 Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule CASP3 APP TRPA1 PMC8759917__F9 Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARA Signaling Pathway SLC10A2 AQP8 ELOVL2 HSPA1A UNG EHHADH CYP7A1 PMC7870803__F10 Diagram depicting the molecular regulation mechanism of the NEAT1/miR-129-5p/PEG3 axis in liver fibrosis of mice with NASH through the NFKB signaling pathway AGO2 PEG3 PMC7143872__F1 Impact of physical activity on bone health RUNX2 SOST IL1B PMC10242642__F1 SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia EFS CDA RRM1 RRM2 DCTD CMPK1 PMC4622586__F1 The classical complement pathway initiated by mAbs and its inhibitors HEL-S-62p CD59 CD46 VTN FH C7 C6 CD55 C4A PMC8872331__F3 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma NF1 PDGFRA MDM2 PTEN RB1 PMC8872331__F4 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma MMP3 RECK TIMP3 MMP9 ADAM17 PMC9866016__F10 Alfalfa Xeno-miR168b Target CPT1A to Regulate Milk Fat Synthesis in Bovine Mammary Epithelial Cells ACADL CPT1A ACADVL CPT2 CEBPB ACADM CD36 PMC5418219__F2 Roles and modulations of toll-interacting protein (Tollip) in acute and chronic inflammation TLR4 IRAK2 IRAK4 PMC7604396__F1 KRAS4B domain organization and RAS signaling pathway at the cell membrane EGF EGFR GRB2 HEL113 SOS1 PMC7313057__F1 Bone metastatisation process SOST BMP7 CDH2 PMC7570423__F1 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 ACE2 TMPRSS2 HEL-S-69p PMC3988238__F1 Dendritic cells initiate T cell immunity in the lymph nodes STAT4 CD40 CD80 GATA3 STAT3 FOXP3 PMC3989954__F1 Crosstalk between mechanistic target of rapamycin signaling pathway and colorectal oncogenic pathways TSC2 TSC1 IGF1 EGFR RHO PTEN EIF4E MTOR SGK1 RHEB PMC7570423__F3 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 C9 C7 C6 VWF ACE2 TMPRSS2 PMC12039146__F7 Schematic diagram of lipid metabolism and its crosstalk with other metabolism pathways PDGFC DGAT2 SLC2A4 PCK1 FNIP2 BDH1 MTOR TG GPAM HK2 FASN PMC8155903__F5 Differential mRNA and miRNA Profiles Reveal the Potential Roles of Genes and miRNAs Involved in LPS Infection in Chicken Macrophages CD14 TLR9 CD6 MYC LBP CD40 IRF3 FADD TLR3 TIRAP PMC11486635__F5 IRFs Respond to TLR Signaling and Participate in the Expression and Function of IFNs TBK1 IRAK1 TRAF3 TRAF6 IFNGR2 IRAK4 MYD88 TASL IFNLR1 STAT1 IFNGR1 IRF-1 IRF4 IRF2 STAT2 IRF7 IRF8 IRF9 CXCL10 IRF3 IFNAR2 IFNAR1 IFNK SLC15A4 TYK2 JAK1 TIRAP PMC9201425__F3 Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis CD14 NR1i1 FOS EGFR TRAF6 IRAK4 PMC11486635__F3 Apoptosis by IRFs TBK1 STAT2 IRF7 TRAF3 TRAF6 IFNGR2 IRF3 IFNAR2 IFNAR1 STAT1 APAF1 TYK2 JAK1 IFNGR1 TRAF2 OTULIN IRF-1 IRF4 FADD MAVS BAX PMC4386406__F2 The phosphoproteomics data PLCG1 BAD SET FLNA VAV1 CREB1 RAC1 MTOR DOK1 ITK BCL10 NFKB1 LCK GRB2 SOS1 SHC1 LAT CDC42 PMC11035723__F1 Early dynamic changes to monocytes following major surgery are associated with subsequent infections CCR2 IL7R CCR4 CD80 CTLA4 PMC4925820__F4 The hunger signaling pathway constructed in the IPA program colored according to genes correlating with circulating leptin levels TH RARA PYY PMC4925820__F6 Genes involved in circadian rhythm pathway constructed in the IPA program colored according their correlation with circulating levels of tumor necrosis factor alpha (TNFA) CEBPE RETN ACACA STRC CEBPG THRA BATF MTUS2 MTSS1 ATF4 HTT TEF NCOA1 NR1A2 JUN PER2 FASN RORC THRAP3 LBR ATF3 NR1C1 NFATC3 DDIT3 PRL RXRA LEP IGF1 BTG1 NPY2R RORA PPARG CRYZL1 PMC4741457__F9 Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination NUMB MYC AXIN2 LNX2 PMC4480235__F5 Signaling by myeloid C-type lectin receptors in immunity and homeostasis KSR1 ARHA RAF1 TNF PMC10894496__F8 Optimized New Shengmai Powder modulation of cAMP/Rap1A signaling pathway attenuates myocardial fibrosis in heart failure RAP1A CCND1 STAT3 PMC8992440__F1 Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review APC ABCG2 C8orf85 ABCC2 ABCB1 UGT1A1 PMC6309125__F1 Hippo Pathway and its canonical upstream regulators AJUBA TEAD4 MOB1A MOBKL1A RASSF4 FAT2 FAT1 FAT3 FJX1 FAT4 TEAD2 TEAD3 RASSF1 RASSF2 RASSF6 FRMD6 PMC5095301__F7 Schematic diagram illustrating inhibition of HMGB1-TLR4 signaling pathway by dexamethasone in renal ischemia reperfusion injury HMGB1 TLR4 IL1B PMC6309125__F2 KIBRA/Hippo pathway as a shunt of stressful input PICK1 AJUBA RHO MOB1A MOBKL1A PMC4480235__F2 Signaling by myeloid C-type lectin receptors in immunity and homeostasis NLRP3 COX2 CARD9 EGR2 RELB RAF1 TNF IL1B PMC9605584__F1 DPP3: From biomarker to therapeutic target of cardiovascular diseases DPP3 ACE2 NQO1 PMC11853993__F7 CD73 downregulated expression induced by TgROP18 and its consequences on dMφ dysfunction EBP ARG1 PMC8561419__F3 Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth PTS KYNU MADD PMC5282447__F2 Summary diagram of JAK/STAT and MAPK signal transduction CNTF EGF CEND1 FGF2 GFAP CNTFR HBEGF JAK1 SHC1 PMC3464875__F7 Signaling involved in MUC4 expression upon Nicotine, IFNG and Retinoic acid stimulation STAT1 STAT3 PMC9688160__F1 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders MAP4K2 TEAD3 MAP4K3 SRC TEAD4 LATS1 RHO AXL LATS2 HEL-S-31 MAP4K1 TEAD2 PMC4631799__F2 ERBB signaling pathway is highly activated in AA PCa specimens ITPR2 EGF BAD MYC SHE HBEGF MTOR CRK STAT1 ERBB4 BTC ERBB2 GRB2 SRC UNK MCL1 TGFA JUN PMC4791944__F1 Longevity: Mapping the path to a longer life IGF1R ETV6 INSR PMC9688160__F4 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders LATS1 LPA PMC2912833__F4 Generation of a biological network of genes of the most significant Canonical Pathways for the Il10-/- (EF·CIF vs CD14 HLA-G NR5A2 SOCS3 FCGR2A IFNAR2 TNF HLA-DRB1 STAT1 COX2 IL18 TAP2 ATF4 SLC27A1 B2M HLA-DMB NFKBIE PMC9688160__F2 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders TEAD3 APC NOTUM GSK3B LRP5 LRP6 TEAD4 TEAD2 PMC3580589__F3 PTHrP signaling pathways during endochondral ossification IHH RUNX3 RUNX2 BAP1 PMC9688160__F3 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders MAP4K2 MAP4K3 APC HTT GSK3B LRP5 LRP6 LATS1 AXL LATS2 HEL-S-31 MAP4K1 PMC3095674__F4 Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway SST TRAF6 BCL2 ECSIT MAP3K7IP1 PMC2912833__F3 Generation of a biological network of genes of the most significant Canonical Pathways for the EF·CIF (Il10-/- vs MAPK13 CYP2C9 ACADVL MFNG HLA-DMB HEL-S-104 NR1C1 IRF-1 HLA-DOA HLA-DMA ALDH2 PMC4286424__F2 Signal transduction pathway of bitter (T2R), sweet (T1R2/3), and umami (T1R1/3) GPCRs in type II taste cells of the tongue PLCB2 CALHM1 TRPM5 PMC10558709__F7 The main findings on HMEC-1 OGA OGT NQO1 PMC3551738__F3 Network analysis of known SLE-associated genes FCGR1A C4B_2 UBE2L3 FCGR2A IRAK1 TRAF6 TNLG2B BLK FCGR3A C1QB C1QA BANK1 STAT4 CRP TYK2 FCGR2B TNFAIP3 PMC4424084__F1 RIG-I signaling pathway TBK1 TANK TRADD IRF3 TRIM25 MAVS RNF125 PMC11829561__F4 Metabolic reprogramming in the tumor microenvironment ASS1 ASL PMC9515385__F11 Scheme depicting the relevance of the PGD2 pathway in AD and its potential as an AD therapeutic target demonstrated by timapiprant (TIMA), a DP2 antagonist SOX2 COX1 MTOR PMC5214989__F2 Mitonuclear gene groups associated with disease in GWAS are significantly enriched for protein–protein interactions TMTC1 FHIT HAO1 GPX4 MBP FBN1 TSEN2 COMTD1 DPF1 ACSL6 MRPS22 DCN MLH3 RAB5B COX18 ACADS STK35 MRPL23 PNKD NUBPL APOE MSRA LYPLAL1 SNCA SLC25A28 VEGFA DLD RPN2 PSAP HEL60 LYRM4 TRIAP1 INSIG1 ARPC2 FADS2 FDFT1 BCL2 IREB2 NOA1 PRKCH BMS1 ALDH2 TERT MTHFD1L ANK2 BAD DCLK1 ACTA2 ACTN1 DDX1 STMN2 HEL-S-15 TFRC APCDD1 BCL2L11 XBP1 ALDH7A1 ERBB4 HEL-S-67p MOBP ATM MRPS6 BIN1 COX11 RHOB SH2B3 CTH ANXA11 SAMM50 SLC22A4 ISL1 TRIB1 PMAIP1 TOMM40 RAF1 MCL1 SUCLA2 RPL27A CYCS PMC2867239__F2 The Primary Cilium as a Hedgehog Signal Transduction Machine GLI3 SHH PMC2867239__F5 The Primary Cilium as a Hedgehog Signal Transduction Machine SAG DYNC2H1 SHH SMO PMC8557709__F2 Hypothalamic endocannabinoids in obesity: an old story with new challenges CORT POMC NPY AgRP ARC LEPR PMC11780528__F9 Working model for the signaling pathway controlling the formation of SGs in yeast under 2-DG treatment LSM7 ORM2 ORM1 PMC2865336__F7 Role of Rad9A in the G2 decatenation checkpoint TOPBP1 CCNB1 RAD9A ATR WRN BRCA1 PMC7349363__F1 Notch signalling and strategies for pharmacological targeting of this pathway DLL4 ADAM10 FURIN ADAM17 HES1 PMC8233288__F2 Moonlighting of mitotic regulators in cilium disassembly PLK1 TTK HIF1A FZD1 FZR1 MCC CPAP CCP110 DVL2 CEP41 NDEL1 NEK1 INVS PCM1 KIF24 MAD2L1 APC CDK5 VDAC3 AURKA NDE1 CALM1 UBE2C CDC20 NEDD9 BUB1B NEK2 C13orf34 PTP4A3 PMC7997455__F1 Error-prone and error-free pathways of DNA double-strand break (DSB) repair PALB2 BRCA2 BARD1 RAD51 PARP1 DNA2 BRCA1 PMC6523720__F1 Epigenetic mediators involved in the establishment and erasure of histone post-translational modifications and DNA methylation, as described in the text CS HDAC3 HDAC10 HDAC8 HDAC7 HDAC2 HEL-S-92n HDAC5 HDAC1 PMC10251820__F1 Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis BAD EGFR MDM2 GRB2 PTEN MTOR PMC3241604__F7 Proposed MAPK pathways and their inhibitors involved in EVT dysfunction during an inflammatory state TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC7754020__F8 Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis KEAP1 SMAD2 SMAD4 TGFB1 PMC2832691__F3 Binding of Herpes Simplex Virus Type-1 Virions Leads to the Induction of Intracellular Signalling in the Absence of Virus Entry MMP10 MMP7 IRF7 NFKB1 RELA BIRC3 MYC SRC IRF3 REL PMC4647878__F4 Schematic mechanisms of action for drugs involved in the three arms of the TORAVA trial STAT1 STAT2 VHL JAK1 MTOR ELL PMC3808218__F1 PI3K/Akt/mTOR pathway TSC2 RICTOR TSC1 EIF4E MTOR IRS1 RHEB PMC9608867__F2 Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection STAT1 ROCK1 TRAF6 BAG2 MYD88 SOCS6 STAT3 PMC7279006__F1 Heme biosynthetic pathway, porphyrias and nutrients ALAS1 FECH AIP UROD UROS HMBS ALAS2 PMC6804961__F6 Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer CDH11 CDH2 MTOR PMC3137974__F1 Signal pathway activation by the main TLR and CLR receptors that detect Candida CARD9 TLR4 TLR9 IRF7 IRAK2 TRAF6 SYK IRF3 IRAK4 MYD88 TLR3 MAL PMC8670125__F7 Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum PDC OTC HPR MAL PMC4992436__F3 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology BCL10 CYLD NLRP12 TRAF3 RELB TRAF6 TRAF2 PMC7895570__F1 Lipid metabolism of cancer LPL ACLY PMC5118783__F3 Roles of Nanog in Cancer SOX2 STAT3 PMC7382785__F4 Illustration of aptamer involvement in cancer immunotherapy APC CD40 CD80 PMC11806174__F3 Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation ADAR ADA CP PMC8238218__F4 Up- and down-regulated DEGs in the adenosine 3’,5’-cyclic monophosphate (cAMP) signaling pathway (map04024) between female control versus female DXM treated (FcVSFt) BRAF AMH NPY RRAD GIP VIP SOX9 SELL PMC4284744__F1 Fibroblast Low-density lipoprotein (LDL)-related protein-1 (LRP-1) signaling in renal fibrogenesis BAD HEL-S-28 PMC12120097__F11 Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation VEGFC BAD FRK APC LRP5 LRP6 PMC6071520__F5 MiRnome circulating in plasma after injury is predicted to be controlled by miRNA processing enzymes and to affect different signalling pathways ITGA1 DGCR8 DICER1 MAP2K1 MAP2 E2F2 SMAD2 DROSHA CDH2 CDK7 CCND2 PMC2727126__F1 Noteworthy, the inhibition of this pathway through COX-inhibitors leads to induction of apoptosis and tumor growth reduction (Figure ) EGF TES PMC8510467__F5 Systematic Review of the Biological Effects of Cordycepin TSC2 RICTOR ULK1 PRR5 MTOR DEPTOR RHEB PMC11640686__F6 Chemically induced reprogramming of RPE into neural stem cells and into neurons in the brain and retina [12,27,46,93] IGF1 CIPC DKK1 PMC9334758__F2 Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies GZMA GSDMC GSDMB GSDMD DFNA5 PMC6105724__F6 Neuropathology following treatment with NP03-lithium GFAP EIF2A GSK3B LRP6 MTOR STAT3 PMC3632644__F2 GLI1 Isoforms and cancer characteristics VEGFA SHH CD24 PMC11640686__F5 Chemically induced reprogramming of ESCs and iPSCs into neural stem cells and into neurons of the brain and retina [2,47,52,54,97,98,99] IGF1 CIPC PMC11640686__F2 Some small molecules and signaling pathways promoting the development of the nervous system (based on the poster https://www NODAL SMAD2 SMAD4 SMO MTOR TGFBI PMC11640686__F3 Chemically induced reprogramming of fibroblasts into neural stem cells and into neurons in the brain and retina [12,36,37,39,41,42,43,85,86] IGF1 CIPC SHH GDNF LPA BDNF PMC3294063__F1A Molecular Pathways: Beta-adrenergic signaling in cancer BAD RAP1A PTGS2 MMP9 SNAI2 SRC IL6 IL12B IFNG STAT3 GATA1 PMC4992436__F1 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology TRAF5 RELA TNF TRAF2 IL1B PMC4992436__F2 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology CXCL13 TRAF3 RELB CXCL12 TRAF2 PMC7541492__F2 Tumor microenvironment (TME) contributes to resistance via EMT CCR2 MMP9 EGFR CCL2 POLI PMC3642156__F1 Host immune response to viral infection (Interferon Signaling Pathways) TLR7 STAT2 IRAK1 TRAF6 TYK2 SOCS1 PMC4314327__F3 Macrophage immunoregulatory pathways in tuberculosis CD6 IL6 PMC9652895__F7 Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer ATF4 BCL2 IL6 IL6R STAT3 BAX PMC8651562__F1 Suppression of InterferonA Treatment Response by Host Negative Factors in Hepatitis B Virus Infection STAT2 IRF7 IRF9 EGFR IFITM2 IRF3 IFNAR2 IFNAR1 USP18 STAT1 ISG15 TYK2 JAK1 PMC4171984__F1 Insulin/IGF-1 signaling pathways TSC2 RICTOR BAD TSC1 IGF1 IGF2 GRB2 INS PTEN GRB10 MTOR IRS1 PMC4420735__F3 A model of telomerase RNP biogenesis NHP2 GAR1 NOP10 TERT PMC2943318__F7 Ulk3 function in Shh signaling pathway SUFU PTCH1 SHH SMO PMC3636752__F1 Distinct activation pathways for different CDKs WEE1 CDK2 CDK4 CDC2 CDK7 MYT1 PMC5531345__F7 Scheme of the pathway mediating the VEGF-induced disassembly of adherence junctions and its regulation by NDPK-B PMC7948516__F1 Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing LPL TG SLC38A1 GLCE PMC5742161__F11 The illustration of CGA protecting against liver fibrosis in vitro and in vivo by regulating miR-21-regulated TGFB1/Smad7 signaling pathway SMAD2 CGA PMC6699068__F1 Notch signaling in bone tissue development NOTCH2 SOST NOTCH1 DKK1 NOTCH3 PMC7339205__F7 PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/B‐catenin signalling pathway PLK1 APC BAX PMC6923660__F8 The activation of leptin signaling pathway in preadipocytes induces adipogenesis and the production of proinflammatory cytokines LEPR MTOR PMC5378934__F8 Schematic model of TBL1XR1-promoting ERK activation and gastric cancer progression MMP7 TBL1XR1 ZEB2 CDH2 PMC5993186__F1 Coproheme decarboxylases - Phylogenetic prediction versus biochemical experiments UROD UROS HMBS PMC6374012__F1 Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach STAT1 STAT2 TYK2 JAK1 SOCS1 PMC4043133__F9 Proposed site of PEP7 inhibition of the AT1R-Erk1/2 signaling cascade EGF EGFR PMC9109208__F5 It's about time; divergent circadian clocks in livers of mice and naked mole-rats CRY1 CRY2 DBP GCK NR1D2 KHK NR1D1 PER2 PER3 PER1 PMC7862069__F3 Inhibitors targeting Bruton’s tyrosine kinase in cancers: drug development advances CD5 MYC MYD88 CD79B CD79A BTK BCL10 BCR BASH CXCR4 LYN SYK CD19 PMC6791698__F1 Metabolic pathways concerning dTTP biosynthesis DHFR GLDC NDP PMC6616624__F5 Main energy metabolism and carbon/nitrogen fluxes in heterocysts CS CIT MAL PMC9223434__F7 Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets STAT1 STAT2 IRF9 IFNAR2 IFNAR1 IRF-1 PMC2040031__F1 INTERLINKING INTERLEUKIN-7 BAD JAK3 JAK1 PMC8122377__F3 Hepcidin Signaling in Health and Disease: Ironing Out the Details SMAD4 MYD88 SMAD1 DKFZp781O1323 STAT3 PMC4911360__F14 Gene-network of not isolated genes selected by Net-Cox in the GSE7390 breast dataset IL9 CCR4 BCL2 MSH2 FGFR2 PMC7422622__F1 Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms HGF TFPI IGFBP7 THBS1 PMC4911360__F11 Gene-network of not isolated genes selected by Adalnet in the TCGA ovarian dataset FZD3 APC GMPR RB1 DHX38 PMC2774752__F1 Puzzles, promises and a cure for ageing PI3 BCL2 PTEN BAX PMC4467383__F4 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery BRD3 BRDT PAF1 BRD4 PMC7444709__F3 Physiological and pathophysiological functions mediated by TRPC4 in response to receptor-operated activation of Gq/11 and/or Gi/o proteins. A & B TRPC4 TRPC1 NACA OTP ITCH PMC4467383__F2 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery BRD3 BRD2 GATA1 BRD4 PMC2808158__F7 Schematic summary of effect of IL-4 priming on phagocytic and secretory capacities of MΦs TRAF6 JAK3 JAK1 IRS1 PMC9630328__F1 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors STAT3 FOXP3 PMC10555535__F1 Metabolic pathway of exogenous and endogenous lipoproteins LPL LDLR APOE PMC9630328__F2 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors CD9 MICB CCR4 CXCL8 CCL5 CCL2 TIGIT TNF IFNG MICA CXCL12 CCL22 AXL STAT3 PMC9141761__F1 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update GSK3B MTOR IRS1 PMC9141761__F2 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update BACE1 APP IRS1 PMC3231999__F1 Immune evasion strategies of Porphyromonas gingivalis CXCR4 GSK3B RAC1 TLR1 PMC7689244__F9 iTRAQ-based proteomics reveals serum protein changes in hypertensive rats induced by a high-salt diet VASP BAD HEL-S-28 SHE ARHA PTEN RAF1 CRK PMC5039409__F3 Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula AKR1B10 REN CHRNA7 ADRB1 EGFR GSK3B ADRB2 POLL ACHE HMGCR TRPV1 COX2 PPARG PMC8008708__F2 Scheme depicting the biogenesis of different classes of EVs RAB35 EGFR ARHA ARF6 PMC5925008__F5 Summary of working thesis of the study NLRP3 IL16 IL1B PMC5761662__F8 Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase NAAA ATF4 ASNS EIF2A TRIB3 ATF3 PMC8634476__F2 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients APC LRP5 LRP6 RYK ROR2 RHO PMC8634476__F3 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients ANGPTL4 DLL4 VEGFA FABP5 HEL-S-104 GPR18 PMC1168814__F8 The regulation of replication-dependent histone H4 genes at the G1/S phase cell cycle transition via the cyclin E/CDK2/p220/HiNF-P pathway relative to the E2F/pRB pathway CDK2 DHFR CDK4 CDK6 PMC8634476__F1 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients TSC2 VEGFC BAD TSC1 SMAD2 DLL4 NRP1 VEGFA PTEN MTOR VEGFB PMC2361340__F5 Differential targets of copy number-induced expression changes in key biochemical pathways between SCLC and NSCLC HMGB1 MAPK9 ING1 EGFR SMAD4 CDKN2A NLK TIAM1 GIG8 CDK2 E2F2 SOX11 CDK4 JUNB KNTC1 DSCAM TCF4 PMC6023588__F4 Metabolic mechanisms of exercise-induced cardiac growth CITED4 MTOR CEBPB PMC6023588__F3 Schematic of glycolysis and ancillary glucose metabolism pathways PC HEL-S-30 PMC10343257__F10 Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha NLRP3 MTOR PMC11676223__F1 Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology NLRP3 ATF4 MTOR UCP2 PMC7880431__F4 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity SMAD2 PTCH1 TGFBR1 PIGH F7 SHH TGFB1 SOX9 UBE3B PMC9265893__F3 Ferroptosis and Its Role in Chronic Diseases GPX4 STEAP3 FACL4 ELOVL6 MTOR PMC5304257__F2 miRNAs control inflammatory response in ECs CXCL1 KLF2 CCL2 PMC9100407__F9 Proteomic Investigation of Molecular Mechanisms in Response to PEG-Induced Drought Stress in Soybean Roots HEL-S-26 CS PC DLAT HEL-S-32 SDHA PMC9701458__F4 Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy CCR5 PIK3R1 CCR2 F10 MAPK8 ALB CCL5 BCL2L1 WAS HIF1A PTGS1 FGFR2 CCR1 MMP3 PRKCA FLT1 FGFR1 KDR NR1i1 GRIN1 MMP2 SRC MAPK1 NOS2 CASP8 SLC5A2 HSPA4 ITGB3 ADRB1 LYZ GSTM1 CDK5 LCN2 ADRB2 HRAS HMGCR CYP2C9 BCL2 ADAM10 SPHK1 HEL-S-72p GP1BA CDC42 FOLH1 MITA BRAF REN PGR ROCK1 TGFBR1 EGFR DPP4 ITGA4 ACHE MTOR CNR1 CYP1A2 INSR BTK TLR4 ERBB4 F2 RBP4 IL2 SELE CFB RAB11A MMP9 PTGS2 ARHA RAC1 MMP16 ITGB1 CFTR HEL-S-69p CASP3 HEL111 MAP2K1 CYP3A4 NFKB1 ZAP70 APRT SYK RAF1 PPARG MME STAT3 PMC8187928__F1 Cellular cholesterol metabolism SQLE CH25H NPC1 FDFT1 ABCG1 LDLR MVK RHO ABCA1 HMGCR PMC7813762__F5 Representative metabolic pathway maps of differentially expressed proteins involved in TCA cycle (A) and proteasome (B) in KEGG RPN2 ARC RPN1 PMC6425834__F2 Models for potential interaction between Toll-like receptor 4 (TLR4) and protease-activated receptor 2 (PAR2).(A) Direct interaction at the plasma membrane model TBK1 CD14 TLR4 TRAF3 TRAF6 IRF3 MYD88 PMC10572466__F6 Schematic drawing illustrating the action mechanisms underlying the effects of baicalin on cytoskeleton rearrangement induced by PVL in BMECs ROCK2 LIMK2 LIMK1 ARHA PMC11676223__F3 Figure depicts the capacity of irisin to affect multiple pathways involved in age-associated neurodegeneration and mechanisms underlying AD pathogenesis IGF1 NGF BDNF SIRT1 FNDC5 PMC9610703__F5 Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery KEAP1 GSK3B IRS1 FOXO1 IGF1 FRS2 FGF10 GRB2 BCL2 RAF1 SIRT1 MAFG BAX PMC3071979__F2 Inhibition of NFKB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice INA EGF CD46 BMP2 PLCG2 MYD88 MAP3K7IP1 HDAC1 UBE2V1 BMP4 LTA SI RELA LCK ZAP70 APP HDAC2 LPP TRAF2 TIRAP PMC8840292__F6 Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus) TIGAR ABCD3 CHIT1 ALK ABCB9 DEK PSAP ddo ABCB11 CERK ABCD2 MAL PMC98985__F3 Overview of metabolic pathways for glucose and xylose metabolism XK XDH tal-1 PMC6677770__F7 Scheme of SAMHD1’s role in HMA metabolism and effector functions CDA DCTD PMC8918542__F1 Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and Pharmacodynamics SULT1A1 CYP2B6 UGT1A9 CYP2C9 PMC7728170__F2 Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis COX2 MMP9 S100A8 CCL20 S100A9 PMC2773646__F1 Nodal signaling pathway NODAL SMAD2 SMAD4 FOXH1 PMC4739231__F1 Signaling pathways demonstrating the link between Gq-coupled receptors and induction of autoimmunity TSC2 PTEN RAF1 MTOR STAT3 PMC9359488__F2 Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination CCR2 STAT2 IRF7 IFITM3 IRF9 IRF3 MYD88 HLA-DRB1 TLR3 IFNG CXCL16 C9 TLR7 TLR4 DBP C6 TYK2 PMC9265893__F1 Ferroptosis and Its Role in Chronic Diseases GPX4 STEAP3 FACL4 SLC7A11 ATF4 DPP4 ALOX15 ADA TPD52 SLC3A2 TF PMC3614511__F8 Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGFB–TAK1–Dependent Mechanism MMP10 HDAC7 MEF2C PMC4516533__F5 Proposed model for EGFR-related signal transduction pathways regulating Snail in Ishikawa (A), Ishikawa ER- (B) and primary human endometrial tumours (C) EGF PAK1 EGFR GSK3B PMC3818893__F6 Hypothetical role of the AhR pathway in the development of inflammatory bowel disease after exposure to environmental PAH AHR PAH IL1B PMC6199630__F12 MAPK and PI3K signaling pathways IGF1R ERBB2 ERBB3 GSK3B SRC RHO PTEN MTOR MEF2C IRS1 CDC42 PMC2857176__F3 Map of selected p53 pathway-associated genes that harbor known or potential functional SNPs (octagon-shaped boxes) and their closely interacting genes (rectangular boxes) ATM DKFZp781B1423 CDK2 MYC MDM2 TP73 CDK4 PMC6733437__F1 Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway MEI1 BAX BOK PMC2147077__F4 A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety FH TES IDI1 IPP PMC7606590__F1 Intracellular model of GH signaling under normal and pathological conditions in Human adipocytes: G0S2 LPL SRC PMC8073060__F2 Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction PDE4D AKAP12 SMAD2 AKAP6 HIF1A CA12 AKAP10 PMC11562642__F5 Schematic diagram illustrating the toxicity mechanism of MNNG in the gastric mucosa and the protection mechanism of FA against MNNG-induced gastric mucosal injury NLRP3 PTEN MTOR PMC3944655__F1 Molecular mechanisms linking ROS, antioxidants, and the insulin signalling pathway PTEN IRS1 SIRT3 PMC9891206__F2 Targeting STING: From antiviral immunity to treat osteoporosis TBK1 CGAS IRF3 PMC6199630__F15 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis FEN1 ATM EGFR HEL-S-92n H2AX PMC8560265__F5 Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway TLR4 BCL2 TNF BAX PMC3072659__F1 Pathways that modulate canonical Wnt signaling EGF HGF APC LRP5 GRB2 LRP6 BCL9 PMC5342722__F7 Sulfatase-1downregulates mesothelin and leads to reduction in lymphatic metastasis BAD CDK2 WNT1 MSLN STAT3 BAX PMC4089392__F1 Toward the development of podocyte-specific drugs FYN TLR4 VTN SYNPO TRPC6 PMC6620681__F1 De novo and salvage pathways for NAD+ biosynthesis NAPRT NAMPT HEL-S-90n NNMT PMC6200785__F8 Indian hedgehog homolog signaling pathway PTCH2 IHH MCM6 MCM2 PGR WNT4 BMP2 PTCH1 KLF4 SOX17 HAND2 PMC8111986__F5A Identification of an immune classification for cervical cancer and integrative analysis of multiomics data HEL2 TPM3 CYP24A1 PMC3193487__F1 Schematic of crosstalk between TLR pathway and MHC molecules BTK TLR4 CD40 IRF3 MYD88 TLR3 PMC6119347__F2 Network created by Ingenuity Pathway Analysis using the top 36 most highly connected genes disrupted by rolandic epilepsy (RE) CNVs as assessed by the Disease Association Protein-Protein Link Evaluator ENTPD2 NRG3 ADAMTS9 HAPLN3 IRAK1BP1 SIRT3 STAT1 DCN ERBB4 ACACB DACT2 ADAM20 ABCC6 JUN NOMO3 DQX1 KLHL17 ADGRA1 ZNF385A TJP1 KIRREL3 DLG2 IKBKB TRIM40 N4BP2 ADAM22 INSRR NRG4 PMC9208181__F1 Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases RHO MTOR CDC42 PMC3255978__F7 Proposed mechanisms underlying the regulatory control of fibrosis development by the PAI-1/uPA balance in aged-associated muscle dystrophy progression PLG SMAD2 PTEN PMC11653397__F5 Proposed metabolic pathway of PCB95 in mice exposed to PCB95 based on the LC–HRMS analysis of intestinal content samples OGT DHDH PMC7066079__F7 Proposed model to illustrate the role of FAM83A in the Wnt and Hippo signaling pathways FAM83A APC GSK3B CCND1 PMC6895193__F6 As a tumor-suppressor gene, RASSF1A mainly acts as a crossroad of three intertwined molecular signaling mechanisms including Ras/Rho GTPases, MTs, and Hippo pathway MOAP1 MAP1B MAP1S RHO MTOR PMC8980946__F1 JAK‐STAT core cancer pathway: An integrative cancer interactome analysis EGF HGF NCOR1 STAT2 LIF PTEN MTOR TSLP STAT5B BRCA1 CDK6 TET1 CNTF STAT1 BCOR PRC1 GAB2 BRCA2 STAT4 GRB2 OSM STAT3 PMC3558831__F6 PIAs recapitulate the activity of two tumor suppressors that converge on mTOR TSC2 PTEN MTOR PMC1856802__F5 Canonical Wnt signalling pathway and its APC partner in colon cancer development FER FYN BCL9 PMC5198184__F1 Metabolic stress-mediated induction of an inflammatory response via ER stress signaling pathways EIF2A GSK3B CCL2 XBP1 IL1B PMC1856802__F2 Canonical Wnt signalling pathway and its APC partner in colon cancer development APC GSK3B PMC3062534__F1 Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort HEL-S-62p CFH FH CFI PMC8712397__F5 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease OGT TRIM28 PMC8712397__F1 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease OGA OGT IMPACT PMC9369364__F3 TM4SF5-Mediated Regulation of Hepatocyte Transporters during Metabolic Liver Diseases AFP SOCS3 TM4SF5 CD34 CCL5 CCL2 SIRT1 SOCS1 PMC10705753__F1 Illustration of semaphorin 6A–D signaling pathways and their interaction with the cellular molecular network in cancer cells ECD SNAI2 ARHA NR1C1 HES1 FGFR1 SEMA6D ZEB2 NOTCH1 SRC CCND1 GNG11 SEMA6B TCF4 STAT3 PMC7880431__F1 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity SNAI1 GSK3B SNAI2 FOXC2 UBB FGFR2 EPHB3 HEL23 CYP51A1 DPH1 TCOF1 FGFR1 MNT GBX2 ACVR2A TBX1 SHH HEL-S-44 GSC COL2A1 OSR2 PLG TP63 WFIKKN2 MAP3K7 LRP6 ALX4 CYP7B1 PHC1 PBX2 CRK GAD1 CDKN1C EDN1 VAX2 RET HSPG2 DHCR7 DHFR F7 TYRO3 TGFB1 SUMO1 CHUK TRADD DKFZp781B1423 EGFR TGFBR2 MSX1 JAG2 GAS1 RYK ADH7 NABP2 DNMT3B TNNI3 IRF6 BMP4 CHEK2 AHR GLCE BARX1 PDGFRA PITX2 WNT9B MYO1D SKP1 MSTN PBX1 DLX1 ITGB8 UBA2 GDF11 EPHB2 PMC10705753__F3 Illustration of the mTOR–Sema6D–PPARG signaling pathway in controlling macrophage polarization toward anti-inflammatory (antitumorigenic) phenotype M2 via regulation of fatty acid uptake and metabolic reprogramming SEMA6D TNF ARG1 HEL-S-104 PPARG CD36 PMC5496883__F3 Signalling by Rho GTPases (upper panel) and Neuronal system pathway (bottom panel) AGER ABCC9 KCNQ5 KCNJ6 CDC42 PMC9688694__F1 Antitumor Activities of Interleukin-12 in Melanoma STAT1 STAT4 IL2RA IRF4 IRF-1 IL12RB1 STAT3 PMC7288986__F1 HDR-mediated genome editing IL2RG CYBB NCF1 PMC5338640__F3 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration SRC ARHA CDC42 PMC12209467__F3 HIF signaling pathway and targeted therapy in PH NAMPT BAD SNAI1 AREG VEGFA KLF5 SNAI2 NCOA6 CCL2 E2F3 RASSF1 TWIST1 ARG2 CXCR4 RRP1B IL33 PECAM1 HEL-S-133P PHB2 PCNA HK2 STAT3 BAX PMC6333681__F1 Environmental pollutant-induced obesity and metabolic diseases: involvement of BAT impairment PRDM16 DDT PPARG PMC5338640__F4 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration WNT3A APC GPT PMC8170118__F3 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data ZYX FOS APP CCND1 BCL2 TLN1 HEL114 ACTN4 PMC12209467__F4 MAPK and PI3K/Akt signaling pathways in PH EGR1 FGF2 PTEN MTOR PAH BMP4 BMPR2 METTL3 SPHK1 SMAD1 PCNA DKFZp781O1323 BAX PMC8170118__F5 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data RASSF1 PLA2G4B RAF1 LAT PMC12209467__F2 BMPR2 and TGFB signaling pathways in PH FHIT HEL-S-28 HEL-S-101 TNF GSAP ID1 HMGA1 BMPR2 NBL1 NOTCH1 SIN3A COMP PFKP PCNA INHBA STAT3 DFNA5 PMC4486076__F1 Autophagy in Autoimmune Disease ULK1 ATG12 ATG3 AMBRA1 ATG101 ULK2 ATG10 MTOR DKFZp686F0183 VMP1 PMC12209467__F7 Wnt signaling pathway and targeted therapy in PH EGR2 TWIST1 LRP5 FZD7 LRP6 ROR2 PCNA TCF4 CDC42 BAX PMC12209467__F8 BMPR2 and TGFB crosstalk with other signaling pathways in PH NOTCH2 HMGB1 BMP6 SMAD2 CXCL8 TNF NOTCH3 STAT1 BMPR2 TLR4 FZD2 SRC FZD7 SMAD1 FZD8 PMC12209467__F5 NFKB and NLRP3 signaling pathways in PH NLRP3 KIF23 CASR HDAC10 NLRC3 PMC12209467__F6 Notch and AMPK signaling pathways in PH NOTCH2 FOXM1 NOX4 TNF MTOR PAH NOTCH3 HES1 FOXC1 BMPR2 DLL4 NOTCH1 SRC TUG1 SIRT1 SKP2 PMC9812393__F8 SKN-1A/Nrf1 lipid homeostasis response PC PLIN1 FITM2 PMC12209467__F9 PI3K, NFKB and AMPK crosstalk with other signaling pathways in PH NLRP3 DLL4 FGF2 TRAF6 PAH NLRC3 PMC11759460__F7 Graphical abstract TFEB POLE LAMP2 PMC5286959__F1 SCFFBW7 ubiquitin ligase targets SOX9 for proteasomal destruction EGFR MTOR SOX9 PMC6566201__F6 Fighting Thyroid Cancer with Microgravity Research EGF CTCF VEGFA LCN2 CPNE1 CXCL8 IL6 CCL2 FGF17 PFN1 IL15 PRKCA MMP2 VCAM1 opn RELA IL17A HEL114 ARF6 EN1 PXN PMC8996529__F6 Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response TH CRAT CAD PMC8422639__F11 Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells HMGB1 BMS1 PMC9063253__F4 V-ATPase in cell death and cancer GPX4 BAK1 CA9 MTOR BCL2L11 TMBIM6 CASP3 TFEB TNFSF10 SLC40A1 CASP8 STAT3 BAX PMC5539153__F8 Representative model of some signaling pathways in a human breast cancer cell (MDA-MB-231) that can be modulated by GCdcPLI COX2 BAD MDM2 BCL2 BCL2L1 MTOR BAX PMC9620650__F2 Role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights ULK1 ATF4 CXCR4 CER1 ATG101 BNIP3 MTOR DKFZp686F0183 SIRT1 PMC128926__F2 Activation of the NFKB pathway by IL-1 IRAK2 TRAF6 IL1R1 MYD88 PMC6789187__F2 Citrate produced through mitochondrial metabolism can enter the fatty acid synthesis pathway COX2 COX1 SCD LPA ACLY HMGCR PMC3398118__F1 Diagram of the pentose phosphate pathway showing substrates and enzymes involved in it RPIA RBKS HEL107 RPE PMC5538844__F10 Cell mechanisms by which MPLA prevents inhibition of absorption by LPS in the MTAL TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC6521490__F3 By KEGG pathway enrichment analysis, ANXA2 upregulated filopodia pathway, resulting in cell metastasis VASP FYN INS SHE RHO HEL114 ATR CRK PXN PMC3713495__F4 EZH2 promotes E2F driven SCLC tumorigenesis through modulation of apoptosis and cell cycle regulation BAD E2F2 DHFR EZH2 RB1 E2F3 PCNA PMC7767241__F1 Diagram highlighting prominent pre- and post-transcriptional interactions between NFKB and the Lin28/let-7 pathways LIN28B RELA MYC RELB IL6 LIN28A STAT3 PMC7786975__F1 Metabolic characteristics of M1/M [LPS(±IFNG)] macrophages RET F2 ACO2 ACLY HIF1A ASL PMC7786975__F2 Metabolic characteristics of M2/M [IL-4/IL-10] macrophages F2 PFKFB1 ARG1 CD36 GLS PMC7601745__F4A Indoxyl Sulfate-Mediated Metabolic Alteration of Transcriptome Signatures in Monocytes of Patients with End-Stage Renal Disease (ESRD) HEL-S-62p GPC4 VASP WSB2 c-fgr ABHD5 LPCAT3 XYLT1 VSIG4 FBP1 CXCL8 TNF POR TRIM25 SOCS6 MCEMP1 ADAM17 CCR1 HSD3B7 PSMB6 FAM20C F5 HEL-75 ITGAV PMC3777336__F4 Differentially expressed genes (DEGs) related to the cell cycle E2F4 SCT ORC6 SMAD2 APC SMAD4 CDC25B STAG1 DBF4 ORC3 E2F3 CDK7 STAG2 ORC2 CDC20 ATM SMC3 CDK2 E2F2 MDM2 ATR SKP2 PMC7862680__F7 Novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway VASP PRTG PMC7330686__F3 Aromatic hydrocarbon in conjunction with CYP1B1 signalling pathway AHR CYP1B1 PAH PMC8717598__F1 Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway FES IPP PMC4436905__F1 Adipocyte secreted leptin and interleukin-6 has a paracrine effect on nearby breast cancer cells SOX2 STAT3 PMC12016271__F10 SFI on podocyte INSR and eNOS proteins in the IR signaling pathway IRS1 INSR PMC7695578__F7 Schematic model showing the hypothesis for COVID-19 infection STAT1 STAT2 TYK2 JAK1 ACE2 PMC4601492__F5 Coronin-1C-mediated Rac1 trafficking CORO1C RCC2 RAC1 PMC6181017__F9 Suggested Schemes for PGI1-Mediated Biosynthesis of MEP Pathway Isoprenoid-Derived CKs and GAs in Cells of Vascular Tissues, and FAs and Proteins in Mixotrophic Maturing Embryos of Arabidopsis GPT IPP HEL-S-162eP PMC4462002__F7 Fanconi Anemia Pathway GIG8 SLX4 LIG1 ATR BCCIP USP1 PMC9277157__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/Beta-Catenin Signaling APC PMC11768371__F7 Mechanism underlying the gedunin-mediated inhibition of C NLRP3 MYD88 PMC8943601__F1 Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases BAD MTOR IRS1 PMC3021862__F4 Genes regulated by Survivin in ITD-Flt3+KSL cells and deregulated in LSC are mapped on functional signaling network associated with epidermal growth factor receptor signaling pathway GNRHR c-fgr EGFR MAPK14 ARHA SPIRE1 IL15 CREM GRB2 VWF SRC RAF1 ETS2 CDC42 PMC4955670__F4 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer AFP PRKCZ MAPK3 MYC TGFBR2 TSPAN8 ARHGEF2 BCL2L1 BCL2L11 CCND3 E2F2 PTPN11 MDM2 CCND1 TFF3 JUN BAX GPC3 FOS LCN2 RRAS RAC1 BRCA1 AURKA CDKN2B NFKB1 IGFBP1 BCL2 TCF4 PMC4955670__F5 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer AFP GPC3 FOS LAMP2 RELB MYC BMI1 GAS1 PTEN FOSL2 TOR2A BEX1 WNT3A MAFK NGFR SERINC3 APP JUNB ETS2 JUN WWOX PMC3554623__F2 Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway TBK1 IRF7 EIF2A IRF3 EIF4E TLR3 PMC4955670__F6 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer ROCK2 EGR1 CCNA2 PLK1 MAD2L1 MAPK3 TGFBR2 TSPAN8 AURKA CDK6 MCM6 CDKN2B CDC6 NFKB1 IGFBP1 CCNB2 PTPN11 CCNB1 MDM2 TGIF1 CCND1 CDK4 TFF3 TGFA PMC7859922__F1 Chemokines in hepatocellular carcinoma CXCR4 CXCL12 PMC4031539__F5 Summary figure of the switch from Pu.1 interaction with coactivators to corepressors caused by Runx1 deficiency CARM1 PBRM1 HDAC3 RBBP4 BMI1 CHD4 ZNF326 SMARCC1 SAP18 SMARCA4 TLE4 SATB1 HDAC2 REST SIN3A HAT1 RUVBL1 SMARCC2 EPC1 CBX1 NCOA5 SUV39H1 BAZ1A SMARCD2 HEL25 DMAP1 RBBP7 SIRT1 TLE2 TLE3 GPS2 CHD3 MBD3 ACTL6A PRC1 SMARCD3 MBD2 PHB2 SAP30 KDM1A RUVBL2 LBR RUNX1 PARP1 HDAC1 SMARCE1 PRMT1 MRGBP TRIM28 SMARCA1 PMC5423041__F1 Molecular mechanisms involved in macrophage inflammatory protein-2 secretion of macrophages TLR4 SOCS3 STAT3 PMC10534417__F1 Putative biosynthesis pathway of limonin MVD MVK IPP HMGCR PMC3117645__F9 The miR-29 regulatory network in Zmpste24−/− progeroid mice PPM1D NARF IFI30 DUSP2 CDC42 PMC3993568__F10 PI3K/Akt1 pathway is a downstream effector of Jak2/Stat5 signaling in luminal mammary epithelial cells PRLR SRC PTEN PRL PMC506992__F7 MUC20 suppression HGF GRB2 MUC20 PMC8708687__F2 Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers HNF4A MYC TEAD4 MTOR TFAM AKT3 PMC9077852__F9 Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/Beta-catenin pathway KIF23 FOXM1 WDR5 PMC3116035__F3 A) Schematic outline of mitochondrial and metabolic pathways connected to the PPP in hepatocytes AFP LPO MTOR TCF4 PMC3199966__F1 Schematic biosynthetic pathways for the major phospholipid (Kennedy Pathway) and sphingolipid classes biosynthesized in mammalian cells and observed in MALDI IMS of mammalian tissues HMFN0839 PC PGP DES SMS PEMT PMC6680887__F3 Dinoflagellate orthologues predicted in the base excision repair pathway MBD4 TDG LIG1 UNG OGG1 MPG PMC7575756__F8 Molecular mechanism underlying the tumor-suppressive effect of miR-766-3p in OS APC GSK3B AXIN1 LRP5 BCL9L LRP6 PMC3760013__F5 Core genes for cetuximab and PX‐866 susceptibility RBPJ EGFR MYC CCND1 MTOR PMC6680887__F4 Diagrammatic summary of the dinoflagellate orthologues predicted in the nucleotide excision repair pathway CETN2 POLE POLK XPC ERCC1 XPA DDB2 PCNA PMC7338796__F2 Crosstalk between the tetrahydrobiopterin (BH4) and kynurenine (KYN) pathways SPR HEL-S-90n KYNU KMO DHFR PMC9617731__F9 Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling TLR8 TLR5 IRF7 PMC6680887__F5 Dinoflagellate orthologues predicted in the DNA mismatch repair pathway MSH3 LIG1 MSH2 PCNA PMS1 PMC2952389__F1 Outline of T-cell development pathway from bone marrow to the thymus RUNX3 ATL1-beta CD48 CD44 TF PMC3390208__F8 Signaling pathway involving CaMKK regulation of GluA1 synthesis and synaptic incorporation as CP-AMPARs MTOR BDNF PMC6518732__F1 STAT3 signaling pathway in cancer cells PTPRT EGF EGFR SRC STAT3 PMC8430839__F2 Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus STAT2 IRF9 TYK2 IFNAR2 JAK1 PMC7751845__F8 Crosstalk between HepG2 cells and TAMs-like macrophages HMGA2 PMC4049898__F2 Wnt and planar cell polarity signaling in cystic renal disease APC GSK3B PTK7 ARHA RAC1 FAT4 PMC2883790__F2 IGF-I activation of a signaling pathway to mTOR TSC2 PI3 TSC1 RHO PTEN RAC1 EIF4E MTOR RHEB PMC6152528__F11 Hypothetical model for the signaling pathway and the role of FKB-induced autophagy in GBM cells RPS6KB1 ATF4 TRIB3 MTOR DKFZp686F0183 DDIT3 PMC6273124__F1 PI3K-Akt-mTOR pathway TSC2 TSC1 PTEN PMC4373479__F1 TLR4 signalling TLR4 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC6510893__F5 The Conserved Response of chickens to NDV infection STAT1 IRF7 IRF-1 SOCS1 MX1 PMC8698417__F4 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation MAF ME1 KEAP1 PMC8698417__F1 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation KEAP1 GSK3B RBX1 PMC11053566__F10 Proposed mechanisms of action of eudesmane-type sesquiterpene lactones on the TNF-Alpha-induced NFKB signaling pathway RIPK1 TRADD RELA TRAF2 PMC7405862__F1 Mechanisms involved in organ damages associated with COVID-19 ACE2 IL1B PMC10518439__F2 Pyroptosis and inflammasomes in cancer and inflammation HMGB1 GZMA GSDMC GSDMB GSDMD DFNA5 PMC5201094__F7 Hypothetic model illustrating the pivotal role of CD37 status for R-CHOP outcome in DLBCL and the important molecular mechanisms for R-CHOP resistance in CD37−DLBCL and CD37+ABC-DLBCL BTK CD37 BCR IMPACT CXCR4 MYC IRF4 ICOS STAT3 POLI PMC6854988__F11 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from BP enriched pathway) AHR RXRG ABCC2 NR1C1 RXRA PMC6854988__F12 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from MF enriched pathway) AHR RXRG NR1C1 RXRA PMC4229533__F1 Pancreatic cancer cell survival pathways in 5-fluorouracil resistance EGF BAD APC GSK3B GRB2 SRC PTEN MTOR CDC42 STAT3 BAX PMC6530474__F10 Diagrammatic representation of constitutively activated TGF-Beta-signaling-mediated tissue fibrosis ACTA2 TWIST1 TGFBR1 SNAI2 TGFBR2 PMC4782570__F7 Proposed regulatory mechanism of insulin expression by the Wnt/Beta-catenin/NeuroD1 pathway in the hypothalamus WNT3A NEUROD1 PMC6995390__F2 Signal transduction pathways in PSCs activation FGF21 IHH RECK SMAD2 SHH RHO PMC8579446__F3 Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 SLC3A2 TF PMC3073278__F1 Tumor-induced DSB formation in vivo SSB CCL2 H2AX PMC7851696__F1 Critical Role of MetR/MetB/MetC/MetX in Cysteine and Methionine Metabolism, Fungal Development, and Virulence of Alternaria alternata BHMT2 GPX3 CBL PMC4959648__F1 Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia NDUFV2 NDUFS1 ND1 ND5 ND4 PMC9539685__F1 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development CASP3 STRN MYC CASP9 STRN3 TIPRL EIF4E CDC2 PMC9539685__F2 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development TIPRL PTEN RHEB PMC10539319__F1 Systemic iron sources and metabolism EPO HEPH IBRDC1 PMC10539319__F3 Testicular iron metabolism and ferroptosis GPX4 LPCAT3 FACL4 SLC7A11 FTL IBRDC1 NQO1 TF SLC39A14 CP PMC2732416__F5 Roles of the ILS pathway and HSF1 in aggregation toxicity and longevity PI3 IGF1 PTEN HSF1 PMC8000993__F7 Simplified schematic of crosstalk between JA and ABA signaling pathways ICE1 SNRK ABI3 PMC4905215__F1 Endothelial-specific loss of GRK2 impairs maturation and vascular remodeling in adult and developmental angiogenesis SMAD4 SMAD1 TGFB1 ADRBK1 DKFZp781O1323 PMC7844244__F8 CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis FOXP3 PMC2862795__F1 Multi-component nature of TGFB and Wnt Pathways GSK3B SMAD4 PMC5498621__F6 Examples of subnetworks in network reconstructed from injured swine brain treated with VPA NAT8L INA ASCL1 NEF3 MYO16 NEFH CCL2 PROX1 XBP1 VIP MEF2D TBR1 THBS1 NEUROD1 PRRX1 FGF7 SNCA RELN KIT SCG5 DAAM2 BMP2 VCAN MGAT5B IAPP CASP3 BCL2A1 CXCR4 NR1C2 GRIN2B CDK5R1 MYT1L SOX10 PHYHIP MAST1 OPALIN MEF2C NR1D1 KLHL4 SYP SIRT1 AGXT2 ST18 TF NFKBIE NEFL NR6A1 PMC6733901__F2 Pyroptosis in cancer: pro-cancer or pro-“host”? NLRP3 NAIP NLRC4 NLRP1 AIM2 IL1B FADD GSDMD DFNA5 PMC6353984__F5 Downregulation of G2/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells ULK1 CCNB1 ATG14 PMC7197765__F1 Cross-coupling reactions of benzylic C–H bonds and alcohols via a radical relay pathway ARX PMC9120423__F1 Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review PMC7393494__F7 Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs FEN1 YY1 ATR PMC11847233__F1 Regulatory effect of lncRNA Erdr1 on T cells CCR6 CCL20 BAX PMC3343703__F1 Heme metabolism FECH UROD UROS CPO PMC7564904__F1 In vitro Bacillus Calmette-Guérin (BCG) training TNF MTOR IL1B NOD2 PMC8364703__F5 Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona RPIA FADD ACOX1 SDHB PMC7163250__F9 Our hypothetical model integrating AMP-activated protein kinase (AMPK), Hippo, and TBK1 signaling pathways during normal (A) and ZIKV-infected states (B) TBK1 CGAS IRF3 LATS1 LATS2 MAVS PMC3732459__F3 Innate Immune Responses in Hepatitis C Virus Infection PRMT1 SOCS3 TYK2 IFNAR2 JAK1 IFNAR1 USP18 PMC6433789__F3 P53-HSF1-PGC1A integrated responses in HD DHRS2 HTT MDM2 HSF1 FBXW7 SSBP1 TAF4 PMC4225745__F1 Interaction between human GD T cell and tumor cell TH CXCL13 MICB CXCL10 MICA IPP IFNG PMC6868871__F6 Summary diagram demonstrating the contribution of IGF-1/IGFBP to transcriptional levels of PPARG, VEGF, and HIF-1A under the administration of BV intervention IGF1 IGFBP1 PMC3732459__F2 Innate Immune Responses in Hepatitis C Virus Infection TBK1 TANK IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TRIM25 TLR3 TLR8 TLR7 MAVS PMC3234494__F3 Cytosolic RNA sensors IRF7 IRF3 NOD2 PMC8868556__F5 Melatonin as a Smart Protector of Pregnancy in Dairy Cows BBC3 LIF MDM2 MTBP BAX PMC4911365__F3 Tumor-supportive effects of BMAT IL15 IGF1 IL6 STAT3 PMC5454774__F1 Scar-mediated inhibition and CSPG receptors in the CNS ARHA PTEN MTOR STAT3 PMC8024996__F1 Struggle of a good friend getting old: cellular senescence in viral responses and therapy CGAS DNASE2 FOXA1 TREX1 IRF3 SIRT3 PMC4417442__F2 HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy NLRP3 TLR8 CGAS CPSF6 TLR7 TRIM50 TREX1 H2AX APOBEC3G IFI16 MX2 PMC10981756__F7 Mechanism of the antineoplastic role of PQR309 and gemcitabine in nasopharyngeal carcinoma CDH2 STAT3 PMC9477421__F5 Schematic diagram summarising the inferred functions of cofilin 1 (CFL1) and fatty acid binding protein 5 (FABP5) that interact with a prokaryotically-expressed (non-glycosylated) recombinant form of the Toxocara canis mucin 1 protein (rTc-MUC-1) UBC ME1 CAP1 FABP5 NEDD8 HEL-S-93 LCP1 PFN1 CORO1A ACTG1 PMC2631405__F1 Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models IGF1 PTEN FOXO1 PMC5147738__F5 Portion of the miRNA-augmented Regulation of lipolysis in adipocytes pathway PIK3R5 PDE3B LIPE ABHD5 MGLL INS PIK3CA HEL-S-104 PNPLA2 INSR AKT3 PMC2912609__F2 Currently available therapies targeting EGFR signaling pathway EGF BRAF EGFR PTEN MTOR PMC5047222__F1 Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression RS1 OGA FOXM1 GAB2 OGT HEL-S-28 MDM2 JAK1 IRS1 CD19 PMC5295433__F8 G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway BIRC2 NAIP AREG LATS1 MCL1 TF PMC3574586__F2 Schematic representation of the sessile and traditional serrated pathways BRAF IGFBP7 PMC6637598__F2 Wnt/Beta-catenin signal transduction pathway APC LRP5 LRP6 BCL9 PMC8089042__F8 Model and Summary: RGS10 regulates pro-inflammatory gene expression through functional interaction with the SOCE machinery UNG TG STIM1 STIM2 PMC8961181__F1 Genetics, Breeding and Genetic Engineering to Improve Cottonseed Oil and Protein: A Review PC LPA LPP PMC8526999__F3 Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells CDK2 APC CYC1 CDK4 USP37 CDC2 CDK6 PMC5449515__F2 Mechanisms governing TGFB1–induced HASM contraction SMAD2 SMAD4 PMC2726710__F2 Intracellular signaling consequences of calpain-mediated substrate cleavage TH BAD SP4 MBP CDK5 SP3 BAX MEF2D PMC11850813__F7 Molecular mechanism underlying knee arthrofibrosis TNC DPP4 EGFR CTGF PMC11186353__F3 Illustration representing the sites of action of different polyphenols in asthma pathway IL33 IL25 TSLP PMC11186353__F4 Illustration representing the sites of action of different polyphenols in cancer pathway PLG RAD51 PMC3735707__F6 Maternal factors required for oocyte developmental competence in mice GPAT2 GPD2 PMC4641965__F1 Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity ADIPOR1 ADIPOR2 NR1C1 UCP2 PMC9523578__F3 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity BAK1 SKP1 CERK PMC8972237__F7 Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells BAMBI INVS CES1 APC SOST NOTUM SKP1 RYK POR NLK RHOD SIAH1 ARC PMC11898993__F8 Molecular mechanism of GNC against IR-induced DOR TH NR3A2 KRT19 POR HEL-S-130P TF PMC9179265__F1 EPA Modulates KLK Genes via miR-378: A Potential Therapy in Prostate Cancer KLK14 MAP2K1 KLK4 GRB2 KLK6 MTOR AKT3 PMC7767317__F3 Modulation of the Nrf2-vitagene pathway by H2S MAF NLRP3 KEAP1 RBX1 SIRT1 PMC6715524__F4 Summary of histone PTM-mediated 53BP1 and BRCA1 DSB repair pathway choice regulation RNF168 MBTD1 BARD1 HDAC2 HDAC1 BRCA1 L3MBTL1 PMC6049856__F1 CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma SET UMPS CAD DHODH PMC11759867__F1 Action of eCIRP in hemorrhagic shock TLR4 TREM1 MYD88 PMC9468507__F5 Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents CRP NR3C1 AIM2 PMC9675387__F3 Oncology biosimilars: New developments and future directions EPOR STAT3 PMC9376779__F4 Transcriptome changes in stages of non-alcoholic fatty liver disease IP6K3 NAMPT NR3A2 RASD1 FOS MYC PEG10 STAT5B KLF6 FNDC5 CRYAA PMC8431582__F1 From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development ERBB3 WNT1 NRG1 SLIT2 BMP4 PMC5793761__F1 Bone morphogenetic protein (BMP) signaling pathway BAMBI MGP SMURF2 BMPER SMAD6 SMAD4 SMURF1 SMAD1 DKFZp781O1323 PMC3922160__F9 Proposed model integrating viral and host biomarkers for disease severity and the effect of IFNB in HAM/TSP STAT1 CD80 HBZ REL CD19 FOXP3 PMC7694276__F2 NcRNA involvement in thyroid cancer-related signaling pathways CXCL16 ADAM9 SCAI ERBB2 FGF2 VHL CCND1 FOXN3 CDH2 MTOR HK2 AKT3 PMC6290322__F4 Moderate heat stress induces nerve growth factor (NGF) signaling including downstream activation of AKT and ERK as well as cyclic AMP responsive element-binding protein 1 (CREB1) transactivation ARHG NGF UNK ARHA CRK CDC42 BAX PMC8657787__F1 Protein Tyrosine Phosphatases: Mechanisms in Cancer CCL5 PMC4040598__F5 Model depicting effect of ADAM17 variant on the canonical TGFB signaling pathway SMAD2 SMAD4 ADAM17 PMC8657787__F3 Protein Tyrosine Phosphatases: Mechanisms in Cancer CSK GRB2 PTEN PMC9376779__F1 Transcriptome changes in stages of non-alcoholic fatty liver disease ME1 RASD1 SLC25A25 THRSP WNT3A IGF1 SCD TRIB1 PKLR FOSB ACE2 KLF6 FGF7 CD36 PMC7801189__F2 Mechanism of cytokine storm caused by SARS-CoV-2 IL33 ACE2 IL1B PMC9376779__F3 Transcriptome changes in stages of non-alcoholic fatty liver disease PML NR5A2 FOXO3A CXCL10 HMGCS1 HIF1A FOXO1 HMGCR IGF1 SHBG SREBF2 F11 PEG10 PPARG PMC3735707__F3 Maternal factors required for oocyte developmental competence in mice KL MOS PGR SMC3 CD2 PTEN TK1 MYT1 PMC2417189__F8 Inhibition of neurogenesis and axis duplication by mkrn2 via PI3K/Akt signaling pathway MKRN2 GSK3B PMC7220691__F4 KEGG pathway of pathways in small cell lung cancer CASP3 FHIT MALL APAF1 CDK2 POLK MYC PTEN SKP2 BAX PMC4131183__F3 TRAIL-induced apoptosis MADD DEDD FADD BAX PMC6905101__F5 Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling SRC STAT3 PMC9392297__F2 Toll-like receptors and their role in neuropathic pain and migraine TLR9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR10 TLR3 TLR7 TLR4 RELA TIRAP MAL PMC6771225__F3 Rational combinations of PARPi with other targeted agents WEE2 CGAS EGFR IRF3 MTOR PMC7874138__F3 HCC cells by SIRT4 GNPAT ACAT1 SIRT4 TRIM21 KLF4 MTOR ARG1 FASN STAT3 PMC3779140__F3 DNA damage tolerance pathway (DDT): lesions (yellow Square) in the DNA template blocks progression of high-fidelity replicative polymerase resulting in stalled replication forks POLG POLN RAD18 PCNA USP1 PMC7411231__F1 Regulatory interactions of the HSC model CDKN2D CDKN1B GSK3B BMI1 TPO CDKN2A CDKN1C CCNE1 CDKN1A ATM MDM2 CCND1 GFI1 CYCS PMC3779140__F4 Proposed model for TLS pathway RAD18 PCNA USP1 PMC3779140__F2 DNA damage signaling at replication forks RAD17 TOPBP1 ATRIP MDC1 ATR H2AX PMC3779140__F5 TLS synthesis in ICL repair by Fanconi anemia (FA) pathway: replicative DNA polymerase stalls upon encounter of an interstrand crosslink (ICL) in DNA REV1 PALB2 FANCD2 BRCA2 SLX4 FAAP24 EME1 ERCC1 FANCL RAD51C PMC3916571__F7 The signaling transduction throughout integrin engagement by Cp aged under oxidative conditions HEL-S-28 SRC PTEN RAF1 JAK1 CP CRKL PMC7332542__F2 Genetic modifications for the establishment of a reductive, carbon dioxide fixing, and redox-neutral pathway from extracellular glycerol to extracellular SA in S ADH5 HEL60 HEL-S-32 MDH2 PMC3999169__F1 Roles for TNF-Receptor Associated Factor 3 (TRAF3) in Lymphocyte Functions TRAF3 CD40 TRAF2 PMC8663543__F1 CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases TH LPA CIT GRAP GLA TF MAL PMC6662509__F3 PPAR signaling pathway and DEGs.Abbreviation: DEGs, differentially expressed genes UBC ME1 PLTP CYP8B1 UCP1 LPL FABP1 PMC7646253__F5 A3 activation of BER and MMR FEN1 GC UNG PMC3555201__F3 HMGB1 in the tumor microenvironment and hypothesis of HMGB1 functioning via NF-kB and epigenetic pathways HMGB1 TLR4 BRMS1 RELA TRAF6 IRAK4 MYD88 STAT3 PMC11495063__F4 Metabolic pathways enriched by DEGs between the EPG and PPG PDX1 MINPP1 NEU1 PC HEXA ACSS1 MCEE SDHA SDHB PMC3594407__F8 Signaling pathway by which Beta-catenin may regulate intricate inflammatory responses in liver IRI LBR GSK3B IRF3 PTEN STAT3 PMC6458269__F1 In response to various stimuli such as infection or injury, mucosal epithelial barriers express a range of signals that ILC2s can integrate IL33 IL25 TSLP VIP PMC7137211__F1 PI3K/AKT/mTOR axis and its alterations in breast cancer TSC2 FGFR1 PTEN PMC9523578__F1 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity BAK1 ETS2 PMC7485553__F1 ACE and ACE2 in the pulmonary system and the tentative role of SARS-CoV-2The top right part of the figure shows the activation of the Spike (S)-protein of SARS-CoV-2 by predominantly TMPRSS2 and also other host proteases such as trypsin and furin FURIN ACE2 TMPRSS2 PMC8639577__F2 The PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions PLCG1 APC VAV1 ZAP70 CD80 PTEN MTOR ICOS SKP2 PMC4449713__F4 Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy TSC2 ULK1 TSC1 ULK2 RHEB PMC2423292__F6 Musashi1 signaling in mammary progenitor cell proliferation NUMB MSI1 DKK3 CCND1 CCND2 HES1 PMC4270133__F5 Applications of DRS PDX1 PMC4982223__F1 Signaling network of drug-induced glioma differentiation GFAP CCND1 STAT3 PMC4801359__F2 miTALOS v2: Analyzing Tissue Specific microRNA Function F2 APC INS DOCK1 RHO NR1D1 PMC8509322__F3 Adaptive Mechanisms of Halophytes and Their Potential in Improving Salinity Tolerance in Plants CLC SOS2 SOS1 PMC9319223__F2 Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation NRF1 MPO COX1 ND4L CYB COX2 ND6 COX3 ND3 ND1 ND2 KEL ND4 PMC11397273__F4 Ubiquitination- and de-ubiquitination-regulating components related to milk fat synthesis DGAT1 RNF5 SCD ACACA LPL ACSL1 MUL1 VPS28 FASN PMC11397273__F5 Model for the promotion of milk fat synthesis in dairy cow mammary cells through the ubiquitination pathway by soysterols and myristic acid DGAT1 MTOR FASN CD36 PMC10779699__F2 Proposed model for the pathogenic role of the NLRP3 inflammasome signaling pathway in RA and its clinical implications as the therapeutic potential NLRP3 IL18BP TNF PTX3 GSDMD PMC7072717__F1 Store-operated Ca2+ entry pathway (SOCE) TRPC4 TRPC1 ORAI1 STIM1 PMC8818415__F9 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma ATM ING1 CYC1 PTEN CAD PMC8150801__F1 Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy ATF2 EGFR RAB27B CDH2 ATR CHEK1 FOXO1 CD24 PMC5863151__F1 Estrogen pathway in lung carcinogenesis and its implications for targeted therapy TH HEL-S-11 CXCR4 EGFR PMC11049926__F4 General model of neuroinflammation in epilepsy CXCL10 CCL5 IL6 CCL2 TNF IL1B IFNG PMC7767648__F4 Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma MYH9 MRPS35 ACTN2 VEGFA STMN3 CRAT NRG1 FMR1 THY1 ARID1A NF1 ITGB4 RPL29 RPS27A PPARGC1A NOTCH1 RPS3 PMC8818415__F8 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma HEL-S-11 PIR PTEN MTOR GLA BOK PMC11988686__F2 Perilla frutescens terpene synthesis pathway; (B,C) P MVD MVK IPP HMGCR PMC8841724__F1 Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives IDO1 AHR IDO2 TDO2 PMC5726781__F4 MELK promotes melanoma growth by stimulating the NFKB pathway HDAC3 NCOR1 AATF SQSTM1 HDAC2 MTDH HDAC1 NCOR2 PMC5647180__F4 Identification of differentially regulated genes within the cellular assembly and organization, cellular function and maintenance and cell death and survival network NDUFAF4 RABL6 AHSA1 TUBB4B SRPX PHLDA1 MEF2C SYNM PDPK1 AGRN PMC8784382__F2 Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases NOD1 ATF4 EIF2A JAK1 RIPK2 TRAF2 XBP1 NOD2 STAT3 PMC5726781__F7 MELK promotes melanoma growth by stimulating the NFKB pathway NF1 BRAF SQSTM1 NRAS PMC2652397__F1 Dual Roles of Nrf2 in Cancer MAF KEAP1 RBX1 PMC3265777__F2 Context-dependent regulation of Rho GTPase signaling CASP3 LIMK2 ECT2 RHOB PMC8473072__F7 MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes FOS JUNB JUN PMC10604999__F1 Scheme illustrating the main hippocampal mechanisms observed in the diabetes-related depression BAD TLR4 HEL-S-11 GC MYD88 BDNF BAX PMC7874138__F6 Breast cancer by SIRT4 SIRT4 IL6 STAT3 PMC8717717__F2 Transcriptomic analysis of patient plasma reveals circulating miR200c as a potential biomarker for high-grade serous ovarian cancer PLCG1 FHOD1 AGO2 MARCKS EDNRA WNT16 VEGFA PIK3CA PTPN13 HEL113 PTEN PMC6166072__F8 Phospholipase D signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs EGF INS RHO LPA MTOR ARF1 RHEB TSC2 TSC1 FYN GAB2 GRB2 AVP SYK LPP PMC7133421__F5 Graphical representation of the PI3K-Akt-mTORC1 signaling pathway TSC2 TSC1 PTEN PMC6166072__F6 Insulin signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs TSC2 BAD TSC1 PDK2 GOPC GRB2 INS EIF4E MTOR CRK RHEB INSR PMC11976707__F2 Key molecular alterations and signaling pathways involved in the pathogenesis and progression of gastric cancer, along with selected targeted therapies (adapted from Lei et al APC PTEN DKK1 MTOR FGFR2 PMC8560752__F7 There might exist a constrained workflow model among ERA, ARSD, and Hippo/YAP pathway TEAD3 TEAD4 LATS1 TEAD2 PMC6642231__F1 The folates and the one-carbon cycle (1-CC) DHFR PMC7565347__F4 Molecular interactions of ZIKV and DENV with the type-I IFN pathway STAT1 ISG15 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC8245133__F6 The putative TAC-induced pathway that culminates in left ventricular hypertrophy TRPV2 PIEZO1 GATA4 PMC4046017__F4 Inhibition of IFNg signaling by MAP EEA1 PTPA PMC11705062__F4 Impact of lysine succinylation on signal transduction S100A10 FBN1 NOTCH1 PMC5810219__F5 Canonical Wnt pathway regulates gene expression by modulating Beta-catenin levels LEF1 APC LRP5 FZD7 LRP6 PMC6959120__F1 Simplified autophagy signaling pathway and regulation ULK1 TFEB ATG12 ATG3 ZKSCAN3 MTOR DKFZp686F0183 PMC7904591__F1 Trained Immunity and Reactivity of Macrophages and Endothelial Cells NLRP3 TLR4 IGF1R CIC LDLR HIF1A MTOR NOD2 HK2 CD36 PMC8891570__F1 Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease ATG12 ATG101 PMC9024672__F2 Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants GCLM GPX4 KEAP1 FTH1 GSTM1 SLC40A1 NQO1 SRXN1 PMC8376648__F8 Proposed working model STRAP IGF2BP2 PMC5445660__F2 Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras IGF1R NRF1 CS LDB1 DKFZp781B1423 UBE2T MTOR MTHFD2 MDM2 FURIN HK2 SPAST NPRL2 C16orf35 BRIP1 MAPKAP1 MLST8 RICTOR DDI2 PPM1D NGLY1 SLC3A2 HEL-S-51e FANCL FANCA LMO2 FANCE FANCG FANCF PMC8718194__F2 Crosstalk between the caspase family and the cGAS‒STING signaling pathway TBK1 CGAS APAF1 IRF3 IL1B PMC8718194__F1 Crosstalk between the caspase family and the cGAS‒STING signaling pathway CGAS IRF7 IRF3 BAX PMC4377108__F2 Regulation of Molecular Pathways in Ischemia Reperfusion Injury after Liver Transplantation HIPK2 TCF3 FANCD2 MYC SMAD4 HIF1A OCEL1 LEF1 MAX ATM MDM2 ATR RBL1 TCF4 PMC3808753__F1 Coordinated action of glial and neuronal purinergic receptors and purines in the CNS LIF BDNF PMC7768132__F3 Regulatory mechanism of KRT19 expression in HCC EGF HGF PDGFRA KRT19 EGFR UNK SRC JUN PMC3428061__F2 Interface between hemostasis and adaptive immunity TH CXCR3 PLG PF4 GC S1PR1 CD40 SPHK1 TF PMC2923204__F2 Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease ARC MTOR BDNF PMC11908050__F1 Glioblastoma signaling pathways MYB ME1 BAD PTEN RAC1 EIF4E MTOR RHEB BCR GRB2 SYK RBL2 CD19 PMC7789326__F4 SHMOs exerting anti-inflammatory effects in NEC NLRP3 TLR4 IL6 IL1B PMC4163377__F1 MicroRNA and their involvement in oncologenic signaling cascades in pancreatic cancer BRAF BRCA2 EGFR MYC MDM2 SMAD4 CCND1 BCL2 RAD51 CDK4 MTOR CDK6 PMC7270402__F1 Immune landscape of the HBV-based tumor microenvironment APC CD80 LAG3 PMC5855642__F1 Sphingolipid signaling pathway S1PR3 SPHK1 PMC4618289__F1 MTOR pathway as a central signaling pathway causing malformations of cortical development and epilepsy TSC2 NPRL2 TSC1 C16orf35 PTEN RHEB PMC5855642__F2 Transformation of SphK/S1P/S1PRs signaling S1PR1 S1PR3 SPHK1 PMC7780621__F3 Role of cytokines/chemokines on tumor progression and dissemination MUC1 VEGFC CXCR4 CCR7 VEGFA IL8RB CXCL12 PMC4125008__F1 current targets of nuclear DNA repair pathway proteins and their functions FEN1 RAD51 PARP1 XPA MSH2 PMC8997978__F4 Label-Free LC-MS/MS Analysis Reveals Different Proteomic Profiles between Egg Yolks of Silky Fowl and Ordinary Chickens NPY PRLH PRLHR AVP NPFF PMC6033950__F6 EE2 and LNG affected the phosphorylation of proteins involved in brain development, synaptic plasticity, neurogenesis, synaptic transmission, and calcium ion homeostasis although the specific phosphorylation profiles varied ANK2 CACNA1B EXOC3 MBP OC90 ZP3 TTN RGS14 TRPV1 RIMS1 PKD1 SPEN ESCO2 SIN3A MKI67 PLXDC2 PBR RBL1 CSPG4 SCG2 AHI-1 SETDB1 PTGS2 APC ENO1 BASP1 OTOF SCN8A SIX4 TSC2 ARID1B KMT2A CREBBP RYR1 IGSF9 HEL113 ABCA1 MAP1A MEF2C PMC6885271__F5 Proposed schematic diagram of LPS-induced ROS-mediated neuroinflammation, neurodegeneration, and memory deficits via dysregulation of the JNK/NFKB/Akt signaling pathway GFAP GSK3B SNAP25 IL1B PMC5408006__F3 Toll-like receptor signaling pathways TLR7 TLR4 TLR9 IRF7 NFKB1 TRAF3 IRF3 IRAK4 MYD88 TLR1 TLR10 TLR3 PMC7565446__F3 Thyroid hormone synthesis pathway (modified from hsa04918) ITPR2 TH GPX4 ALB DUOX2 PDIA4 CREB1 TPO HBXBP SLC26A4 TTF2 ATF4 ATF6B HEL-S-89n ADCY1 DEHAL1 ADCY3 TG DUOXA2 PLCB1 HEL-S-125m TSHB PLCB4 PLCB2 CANX HEL111 PRKCB TSHR ADCY6 HEL-75 GNAS ADCY9 PMC2519632__F6 Proposed model of KSHV-induced lymphatic reprogramming of endothelial cells PROX1 STAT3 PMC6089768__F11 miRNA-145 inhibits myocardial infarction-induced apoptosis through autophagy by Akt3/mTOR signaling pathway in viv and in vitro MTOR DKFZp686F0183 AKT3 PMC8167159__F2 Strategies to tackle RAS-mutated metastatic colorectal cancer EGF CD47 EGFR MDM2 CDK4 PTEN MTOR CDK6 PMC3997659__F1 Role of Ub and SUMO modification of PCNA REV1 POLL RAD18 PCNA PMC7734173__F1 Endosomal and cytosolic DNA sensors and their related signaling pathways TBK1 CGAS IL16 IRF7 DHX36 DDX41 IRF3 MRE11A AIM2 MAVS PMC7718081__F8 Chronic ethanol exposure on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats HMGB1 ARC BDNF PMC3549535__F3 Innate immune stimulation by LPS positively impacts T cell priming TLR4 HEL-S-92n CD80 MYD88 TNF PMC4451963__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 BCL9 PMC5540157__F1 The Shh signaling pathway SUFU PTCH1 CCNB1 SHH SRC SMO PMC11727972__F6 Bile acids (BAs) regulate cancers via the farnesoid X receptor (FXR) MMP7 SOCS3 MUC4 RUNX2 EGFR SRC MTOR STAT3 PMC6125328__F1 Signaling via MALT1 downstream of various receptors and CARMA/CARD proteins CARD9 BCL10 BCR CYLD HEL-S-11 OSCAR SRC SYK PMC6125328__F4 CARMA/CARD-dependent and-independent MALT1 activation PLCG1 BCL10 BCR PLCG2 CTLA4 ICOS PMC8402453__F4 Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development TBK1 CGAS IRF3 PMC4546272__F3 Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma CDC20 CS RASSF1 PLK1 CDK2 APC CDC2 SKP2 PMC9412366__F2 Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections TBK1 NLRP3 STAT2 IRF9 IRF3 TYK2 JAK1 PMC3795378__F2 Tumor (SVZ) micro-environment SHH GDNF BMP7 CXCL12 BDNF PMC7113505__F2 microRNA (miRNA)–gene–pathway network based on miRTarBase and WikiPathways as described in the Methods section RAB14 SMAD2 MYC TGFBR2 SMAD4 PTEN HIF1A CCND3 INSR STAT1 FGFR1 KDR CCND1 MAPK1 CDK4 FASN BAX ROCK2 VEGFA ARHA IL6 SMURF1 HDAC1 FOXO1 NLK TSC1 TIMP1 IGF1 SPI1 TGIF1 BCL2 TGFB1 STAT3 PMC8998820__F4 Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway CGAS NLRC4 NLRP6 MYD88 IL1B PMC3429585__F1 DKK1 as a novel target for myeloma immunotherapy CCR5 CCR6 CCR7 CD40 CD80 DKK1 PMC8588554__F7 Diterpenoid Compounds Isolated from Chloranthus oldhamii Solms Exert Anti-Inflammatory Effects by Inhibiting the IKK/NFKB Pathway CD14 TLR4 PC LBP TRAF6 MYD88 PMC6521797__F2 Siglec-7 mediated inhibition of NK cell cytotoxicity towards tumor cells MICB SRC MICA SYK PMC5752241__F6 The WNT signaling pathway activated by PRP NFATC1 APC GSK3B LRP5 CCND1 LRP6 DKK1 PMC7493839__F3 Application of CRISPR-Cas9 in construction of TCR and CAR T-cells CTLA4 IL-21 LAG3 B2M PMC11310285__F1 Hypoxia signaling pathway VHL HIF1A TF PMC3077564__F3 Activation of glia and neurons in the dorsal horn of the spinal cord after peripheral injury CCR2 CX3CR1 ERBB2 NRG1 CCL2 BDNF ADRBK1 PMC11310285__F2 Hypoxia pathway proteins-microRNA-phosphodiesterase crosstalk in steroidogenesis regulation HSD11B2 HSD11B1 CYP11A1 PDE2A HIF1A CYP17A1 STAR PMC11889408__F1 IL-6 family cytokine signaling pathway CNTF SOCS3 LIF ERAS MTOR OSM TF STAT3 PMC12073115__F4 Mammalian RNA-dependent mRNA amplification is enabled by the integrated stress response ELF2 DELE1 ATF4 OMA1 ATF5 PMC7004969__F1 Selected important players of osteoblast differentiation DKK3 MSC PTH CCL3 PMC11997338__F9 Working model showing a positive role of DSP in the migration and endothelial differentiation of DPSCs through DSPaa34–50–ENGZP association and subsequent activation of AKT1 signaling pathway FLT1 ANGPTL4 ENG THBS4 PMC8957861__F1 How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment HEL-S-62p PLG CRP TF CP PMC8423996__F2 GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism SOCS3 ACE2 ADAM17 SOCS1 PMC4117634__F9 Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1 BTK KEAP1 MYD88 MAL PMC6428452__F8 p38gamma MAPK-promoted EMT ERBB4 ERBB2 SUZ12 GATA3 PMC12210305__F6 High-temperature stored soybean meal on MAPK and FOXO signaling pathways in broiler jejunum tissue CD14 EGF TRADD FLNA INS PROC SMAD4 PTEN TNF NLK PRMT1 MCC MAX ATM CDK2 MDM2 CYC1 JUND ECSIT KLF2 BNIP3 MEF2C SKP2 STAT3 PMC4646664__F1 Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics TSC2 TSC1 C1GALT1 PTEN EIF4E RPS6 PMC7033549__F9 A working model depicting the relationship between proline and polyamine in wild type, PvP5CS OE and RNAi transgenic plants under control and salt stress conditions PRODH PMC3726361__F4 Focal adhesion signaling pathway highlighting those genes that are differentially expressed compared to untreated control ovaries and identifying by color the treatment group(s) from which the differentially expressed genes came VASP BAD FYN HEL-S-28 FGF2 ARHA PTEN JUN PARL INHBA PMC4994475__F1 Network of reported candidate genes associated with GTS CTTNBP2 ADRA2C PSEN2 HEL-S-1 MYC CTNNA3 LHX6 DRD1 RCAN1 DRD4 KCNE1 KCNE2 NR1C1 HDC BTBD9 MRPL3 SLITRK1 DLGAP3 DRD3 HNF4A PSEN1 NRXN1 ADRA1A SLC1A3 PMC3304298__F1 AKT signaling pathway BAD HEL-S-28 PTEN MTOR IRS1 TSC2 RICTOR TSC1 BCR GAB2 LYN MDM2 PFKFB2 CCND1 SYK JAK1 GAL MYT1 CD19 BAX PMC9277406__F1 Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs CYP3A4 APC UGT1A1 PMC3518872__F4 Three IPA Canonical Signaling Pathways: CD40, IL-1, and Chemokine Signaling in TGFB1+LPS+IFNGamma-treated astrocytes ROCK2 CCR5 MAPKAPK2 CCR3 TRAF3 ATF1 TRAF6 ARHA RHO MYD88 MAP3K7IP1 LTA FCER2 TRAF5 CXCR4 TRAF1 UNK CD40 ECSIT JAK1 TRAF2 STAT3 PMC2726075__F1 EGFR signaling pathway EGF MYC CCND1 PMC2766677__F7 Proposed scheme of the signaling pathway leading to immature dendritic cell chemotaxis upon exposure to M-tropic gp120 CCR5 PMC3518872__F3 Top three networks of significantly associated molecules in TGFB1+LPS+IFNGamma-treated astrocytes PDE1B TMEM43 MLF2 POLR3E CH25H GLO1 COL16A1 AEN HTT MSH6 SERPING1 WLS KCNK2 TP53RK ENO3 VAPB GM2A APOBEC3B TP63 KCNJ12 DDIT4 GLRX NINJ1 HEL-S-64p ETHE1 SEZ6 LITAF SESN1 SLC2A6 TNFRSF10A NFATC2IP GTSE1 MTUS1 CSN3 OSGIN1 SCN3B TPR PLAGL2 KRT23 LGALS4 SLMAP CRCP MPV17L SH3BGRL2 SEPHS1 MORC3 MANEAL RCN3 RABEP2 ZNF318 RNF34 KIF3C ZNF346 TPRKB NPM3 CORO2B MIS18A HEL-S-75 MPDZ SNRK ZNF365 PHGDH DNAJC3 RRM2B SRM DAP3 KLF9 PMC3518872__F6 GPCR Canonical Signaling Pathways CAMK4 ADRA2A GRB2 SRC PMC491841__F1 Consensus model of the cell cycle control mechanism in budding yeast SWI5 CIB2 CDC20 APC NET1 PMC7311199__F3 DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer TBK1 NLRP3 CGAS RIPK1 RIPK3 IRF3 AIM2 MLKL GSDMD DFNA5 PMC5122382__F9 Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule CDK4 MTOR PMC5746573__F2 Ca2+ and ROS crosstalk between ER and mitochondria, with emphasis on redox control of the MCU HEL-S-64p MCU C6orf79 PMC11915041__F4 Research progress on the role of decorin in the development of oral mucosal carcinogenesis DCN IGF1R TIMP3 VEGFA PMC5346035__F1 PharmGKB summary: macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics SLCO1B1 CYP3A4 ABCC2 ABCB1 ORM1 PMC7015241__F10 Working model describing how MYPN and PALLD may promote SRF signalling PALLD MYPN PMC3545835__F1 Principal platelet membrane receptors and signal transduction pathways VWF SYK PLCG2 PMC3669920__F1 Schematic of neuregulin-ERBB4 signaling showing the roles of the products of the selected genes BACE1 NRG3 EGF ERBB4 NRG1 PMC6056829__F1 GPI biosynthesis in yeast GPT PMC5393394__F5 Network analysis for the RS fraction proteins with increased secretion upon intracellular LPS stimulation SERPINC1 CD14 FCGR3A GMFB B2M HLA-DRB1 HEL-S-128m HEL-S-104 BAX HEL-S-22 PMC9317051__F3 Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia SET BCR GAB2 GRB2 SMO JAK1 EZH2 MTOR CRKL STAT3 PMC3269020__F3 Role of miRNAs in aging of mice IGF1R IGF1 BCL2 SP1 SIRT1 PMC3269020__F1 Pathways involved in aging IGF1R NRF1 IGF1 MAP2K4 PTEN COQ7 PMC5422712__F8 CD40-mediated apoptosis in carcinoma cells TRAF1 TRAF3 CD40 BAX PMC9936654__F10 Transcriptome analysis of Populus × canadensis ‘Zhongliao1’ in response to low temperature stress CETN2 CCNH XPC ERCC1 XPA LIG1 RBX1 CDK7 PCNA PMC11722408__F2 Mesenchymal Phenotypes Utilize Autocrine and Paracrine Signaling to Reinforce SCLC Subtypes TH EGF KIT L1CAM ENHO CD46 PTN YBX3 PEMT HES1 MPZ opn TPD52 SP1 AXL JUN PTPRM CSPG4 AGRN PMC10379601__F5 Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis DHCR7 EBP DHCR24 HSD17B7 CYP51A1 PMC11098888__F4 CCL1/CCR8, CCL3/CCR5, CXCL6/CXCR2, and CXCL12/ CXCR4 axes in esophageal squamous cell carcinoma CCR5 CXCR4 SRC IL8RB CXCL6 RHO PTEN CXCL12 GAL CCR8 CCL1 CCL3 PMC5554756__F3 Negative regulators of the RIG-I-like receptor signaling pathway USP15 PLK1 SMURF2 NLRX1 TRAF3 IRF3 TSPAN6 EZH2 MAVS RNF125 PMC5554756__F1 Negative regulators of the RIG-I-like receptor signaling pathway TBK1 USP15 TRAF3 TRAF6 IRF3 TRIM25 MAVS TRIM65 PMC5554756__F2 Negative regulators of the RIG-I-like receptor signaling pathway TRIM13 USP15 USP2 ARL16 RNF122 ARL5B USP25 TRIM25 TRIM59 NOD2 MAVS RNF125 PMC7381287__F1 LPS signaling IL10 TBK1 TLR4 LBP IRF3 MYD88 IL1B TIRAP PMC11979484__F9 Hi-Exos in relieving the senescence of NPCs and IDD AGO2 IL6 DDIT4 PMC10458661__F2 TLR and RLR signaling pathways present in airway epithelial cells in response to viral infections TBK1 TLR8 TLR7 TLR4 TLR9 MYD88 TLR3 PMC2934757__F1A Defining the pathway to insulin-like growth factor system targeting in cancer IGF1R IGF1 IGF2 GRB2 IRS1 IGF2R PMC3720640__F3 Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance PTPRS CCND1 SRC PTEN PMC5184782__F1 Context-dependent TGFB signaling pathway ITGB3 YAP1 PEAK1 SMAD2 GRB2 SMAD4 SRC SIX1 PMC171388__F7 Model of Cripto’s inhibition of Act B signaling through the Smad2 pathway NODAL CRIPTO SMAD2 PMC10380015__F2 Challenges and Future Trends in Atopic Dermatitis IL36A IL33 TRAF6 IL1R1 MYD88 IL18BP PMC10380015__F3 Activation of the adaptive immune system via various receptors, different interleukins and its receptors, and the Janus kinases (JAK) STAT pathway IL13RA2 IL13RA1 TSLP STAT1 BTK AHR STAT4 SYK TYK2 JAK3 JAK1 TRPA1 STAT3 PMC6580124__F7 Mechanism of rapamycin’s anti-angiogenic and anti-lymphangiogenic effects in melanoma VEGFC VEGFD VEGFA MTOR PMC7915726__F1 The Mer receptor tyrosine kinase (MERTK)-mediated signaling pathway in epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) resistance EGF SOX2 PROS1 HGF TULP1 EGFR SRC NRG1 MERTK MTOR STAT3 PMC6667871__F8 Schematic model depicting the mechanism of DEPDC1-induced HCC progression CCR6 CCL20 DEPDC1 PMC7915726__F5 MERTK in Yes-associated protein (YAP)-mediated EGFR-TKI resistance EGF FOXM1 EGFR MOB1A MOBKL1A PMC3627331__F1 CD30 signals through TRAFs: upon stimulation by CD30L, CD30 recruits TRAF2 via interaction with its TRAF binding motif, resulting in TRAF2 degradation TRADD TRAF3 RELB CD40 TNF TRAF2 PMC6513092__F7 PIN1and PTOV1 pathway interactions PIN1 MAPK8 PTOV1 CCNB1 BAX PMC6315738__F1 Intestinal uptake of non-heme iron and its regulation HEPH HEL-S-11 FES PCBP1 PMC12090806__F7 Role of TRIM22 in antiviral immunity TBK1 ELF3 NLRX1 IRF3 MAVS PMC5706953__F1 KEAP1 glycosylation regulates the NRF2 pathway GCLM OGA KEAP1 GCLC SLC7A11 OGT HMOX1 NQO1 PMC4446875__F10 Schematic diagram depicting the conceivable cellular events by which MIOX disrupts mitochondrial integrity under HG ambience, which results in renal tubular cell injury PINK1 MFN2 MIOX FIS1 PMC126171__F5 Different telomere damage signaling pathways in human and mouse cells CDK2 CDK4 CDK6 PMC6171574__F3 Signal transduction initiated by transforming growth factorB1 (TGFB1) BMP1 PMC6037039__F4 Functional mechanisms of lncRNAs in vascular disease NAT8L IL1A LARP1 CX3CL1 VEGFA HOXC6 CCL5 HAS2 DYNLRB2 GPR119 MDM2 KLF2 SPHK1 TUG1 EZH2 PMC4150931__F1 Signaling pathways that induce epithelial–mesenchymal transition (EMT) IMPACT GSK3B ARHA RHO PMC4124648__F2 Possible therapeutic interventions on molecular mechanism inducing necrotizing enterocolitis HMGB1 EGF TLR4 PMC8026578__F2 MicroRNAs in the pathophysiology of addiction ADCY1 MAPK3 CREB1 GRIA2 GNAI1 PS1TP5BP1 CALM1 PPP1CC HEL-S-80p MAP2K1 PRKCB RAP1A MAPK1 GNAS RAF1 ARAF CAMK2A ACTG1 PMC10298332__F4 The TNF signalling pathway by M-glucans HEL-S-62p SOCS3 TRADD LIF TNF NOD2 CASP3 MMP14 CSF2 IRF-1 FADD MLKL SELE IL18R1 ITCH PMC6391339__F1 Biogenesis of miRNAs AGO1 DGCR8 DCP2 DROSHA CCR4 EIF4E RAN PMC10298332__F5 The C-type lectin pathway by M-glucans CYLD MDM2 CCL17 RELB ARHA SYK TNF CCL22 IRF-1 PMC8615411__SF1 Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues CYP27A1 CYP2R1 CYP24A1 PMC9326176__F2 Cathepsin K+ Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications IHH CTSK BMPR1A STAT3 PMC10298332__F6 The IL-17 signalling pathway by M-glucans MMP9 TRAF3 TRAF6 S100A9 USP25 IL17RB IL17RC IFNG MCC COX2 FADD TRAF4 TAB3 PMC9623337__F1 New insights into Chlamydia pathogenesis: Role of leukemia inhibitory factor SOCS3 LIF GRB2 JAK1 STAT3 PMC4729089__F1 Metabolic pathway of monoamine neurotransmitter synthesis and degradation TH PAH PMC3897220__F9 Concept map of Whi5 function MIP tal-1 POLI PMC6216037__F8 Oxidative stress-induced autophagy and endothelial dysfunction BCL2 BAX PMC10951504__F5 Underlying mechanism of obesity and hyperuricemia REN GPT ALB INS IL6 CCL2 TNF NR1C1 HEL-S-162eP LEP APOB POMC CRP JUN APOE PMC5087126__F2 Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways TBK1 TRADD STAT2 IRF7 CSF3 IRAK1 IRF9 RELB TRAF3 TRAF6 IRAK4 IRF3 IFNAR2 MYD88 TLR3 TLR7 TYK2 JAK1 STAT3 TAB3 PMC10951504__F6 Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology LEP POMC SOCS3 TRADD NPY AgRP TNF MTOR TRAF2 STAT3 PMC7316587__F2 Molecular mechanisms proposed for NHE isoforms in cancer EGF HGF EGFR SRC RAC1 CDC42 PMC8387950__F8 FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARA Pathway ACACA NR1C2 GCK NR1C1 PMC8088471__F7 Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling SUFU PMC11873051__F1 Resistance mechanisms to CDK4/6 inhibitors NF1 FGFR1 ERBB2 CDK2 FGFR3 CDK4 PTEN FAT1 FGFR2 AURKA CDK6 PMC6536409__F7 LncRNA TNRC6C‐AS1 facilitated cell proliferation and inhibits cell apoptosis and autophagy by promoting the methylation of STK4 promoter region via the Hippo signalling pathway STK4 LATS1 DNMT3B LATS2 PMC8999734__F4 Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway MMP3 TLR4 MMP9 MYD88 PMC6148449__F1 SRP54 and a need for a new neutropenia nosology SRP54 HEL103 SRP14 EIF6 SRP68 SRP9 EFL1 SBDS SRP19 PMC6127670__F7 Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry GCM1 CS DNAJB6 HSPA12B ACO2 KGD4 UNK DLD OGDH PDHX SDHA PMC9253705__F40 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway CTSK MMP2 NFATC1 STAT3 PMC11921819__F4 Ferroptosis in Tumor Immunity GPX4 SLC7A11 SLC3A2 CD36 PMC2014644__F2 PGE2-EP receptor signaling pathways EGR1 EGFR GSK3B CREB1 PMC11921819__F5 Cuproptosis in Tumor Immunity STAT1 HMGB1 CGAS LOXL4 CCL2 IFNAR1 STAT3 PMC11921819__F1 Molecular mechanisms and crosstalk among five cell death modalities: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis NLRP3 GPX4 LIAS LPCAT3 APAF1 FES TNF TRAF2 DLAT FADD ZBP1 GSDMB PMC6371813__F1 Protein synthesis and degradation pathways in skeletal muscle EIF4E IRS1 FOXO1 PMC7551806__F1 Putative molecular mechanisms involved in the development of sarcopenia during aging IGF1R IGF1 SMAD2 MTOR PMC3190192__F1 PRL crosstalk with estrogen, progesterone, EGF/TGFA, and IGF-I EGF TGFA PRL PMC11792170__F2 Part of IL-27 signaling pathways in obesity and other related metabolic diseases UCP1 APC ABCA1 MTOR STAT3 PMC7557985__F1 Involvement of p38 MAPK, ERK MAPK, and NFKB signaling pathways in osteoclast differentiation mediated by RANKL and BMP2 BMP2 DCSTAMP PMC7139475__F5 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea NPY ACHE STAT3 PMC7139475__F2 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea NLRP3 NGF GSK3B BDNF IL1B SGK1 SIRT1 PAF1 PMC8869474__F1 Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla NR1i1 CYP2R1 DHCR7 CYP24A1 CYP27B1 PMC3347988__F4 Schematic overview of the pathway controlling translational changes in adipogenesis MYC POLL EIF4B POLI PMC3717195__F1 DNA repair systems PARG APTX WRN FEN1 RNF8 ATM TOPBP1 ATRIP RAD50 RAD51 TDP1 MDC1 XPC PARP1 DDB2 LIG1 MRE11A DDB1 BRCA1 XAB2 ERCC1 XPA ATR PNKP PCNA PMC8564965__F2 Fibroblast growth factor receptor fusions in cancer: opportunities and challenges FRS2 STAT3 PMC8130302__F2 Effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation NLK LEF1 ROR2 RHO PMC11792170__F1 Some immune cells regulated by IL-27 STAT1 STAT2 EBI3 STAT4 TNF GATA3 STAT3 PMC6208373__F7 Toll-like receptor signalling pathway shows similarities, but also differences between LPS and LPS + IFNG CD14 CTSK IRF7 IRAK1 TRAF3 TRAF6 IRF3 IL6 MIP RAC1 TNF TLR1 PDC PIGA FADD TIRAP PMC6410520__F1 Microbial-based production of nutraceuticals from simple carbon sources STS ASPA IPP PMC9026333__F6 Heparan Sulfate, Mucopolysaccharidosis IIIB and Sulfur Metabolism Disorders CTH HEL-S-64p pcap CBL PMC4870992__F2 Pathogenesis of Hepatocellular Carcinoma MYC TERT PMC4110660__F2 In silico network and pathway enrichment analysis SRP54 ZBTB7A RBBP4 SMAD2 HSPA2 USP33 MYC ARID2 IKZF3 DHPS PSMC6 MSH6 IMPDH1 HDAC2 MAPK1 HMGCS1 SSBP2 DDB1 BRCA1 CUL4A UBE2E1 PPIF CUL4B DIDO1 KPNA2 PSMD2 GEMIN5 PSMD11 CRBN ZFR MAGED1 CTCF TET1 UBC IKZF1 GNL2 CCNB1 TNS3 SPEN NUP155 SIN3B ZNF485 PRDM15 SKA3 NFATC3 NUP153 CREBBP EP300 AHSA1 STUB1 DNAJA2 PMC7766597__F1 Four different types of regulated cell death NLRP3 GPX4 TRADD NLRP1 AIM2 MLKL BAX PMC6526899__F3 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway CS NDUFA5 ZNF183 NDUFB8 NDUFA9 COX6B1 UQCR10 COX7B SDHD NDUFS8 NDUFB5 SDHB CCS NDUFS4 ETFB NDUFV2 NDUFB9 NDUFA7 NDUFB2 NDUFS3 PMPCB NDUFC2 UQCR11 NDUFB4 NDUFA3 NDUFB3 CYC1 C6 NDUFC1 SUCLG1 CYCS PMC6526899__F4 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway SLC25A20 DHX58 CPT2 RTP4 PCCA MRPS28 DBT OLA1 PCCB ITIH4 MRPL30 MX2 MRPL42 MRPL20 HEL-S-26 MRPL9 OAS2 PTCD3 FH MRPL12 KNG1 ALDH3A1 ETFA MRPS15 PMC6555965__F1 Schematic diagram of lipid biosynthesis pathway in Schizochytrium sp CIT MAL PMC6526899__F2 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway OSBPL6 GANC PKIA CAND1 CAD RORA PMC4178034__F3 Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response TRAF6 MYD88 BPI PMC3724874__F7 Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest BAD BCL2 BAX PMC6636202__F8 Illustration of the miR-153 gene pathway in bladder cancer cells IDO1 IL6 IL6R STAT3 PMC3213081__F1 The P2X7 Receptor in Infectious Diseases NLRP3 ARHA ARG1 IL1B CEBPB PMC3162452__F7 Schematic representation of intracellular pathways implicated in the regulation of cholesterol homeostasis and inflammatory response in human macrophages by IL-6 ABCA1 STAT3 PMC5922990__F9 Antiviral properties of naringenin VLDLR NR1C1 HMGCR PMC5954269__F1 Vitamin D Pathways: An Overview (source: Nutrients 2016, 8, 319) CYP27A1 CYP2R1 DBP CYP24A1 PTH CYP27B1 PMC6088103__F4 AD genes selected by cross metrics analysis and their relation with other diseases NGF PTGS2 GSK3B VEGFA IL6 CCL2 TLR4 AGER PSEN1 APP HEL-S-44 BDNF TGFB1 PMC5922990__F6 Naringenin prevents acute and chronic CCl4-induced liver damage MAF KEAP1 SMAD4 FADD BAX PMC5922990__F7 Naringenin in cancer development EGF CDK2 FOS MMP9 EGFR GRB2 BCL2 CSA2 JUN PMC4822554__F1 Glucose promotes tumor growth by activating lipid synthesis and uptake upon N-glycosylation of SCAP EGFR LDLR PMC2778955__F10 Expression of an IKKG Splice Variant Determines IRF3 and Canonical NFKB Pathway Utilization in ssRNA Virus Infection RELA IRF3 MAVS PMC11972266__F2 Isorhamnetin inhibits cholangiocarcinoma proliferation and metastasis via PI3K/AKT signaling pathway MYB BAD CD37 EBP PTEN EIF4E RXRA TSC2 BCR CYC1 SYK SKI RBL2 CD19 PMC7997989__F9 TDP-43 and PINK1 mediate CHCHD10S59L mutation–induced defects in Drosophila and in vitro CHCHD10 PINK1 C9orf72 PMC3427417__F7 Nicotine-induced A7nAChR/JAK2 pathway in cooperation with nicotine-mediated ERK1/2 activation potentiates STAT3 activation in PC cells CS PC MUC4 STAT3 PMC5890734__F1 Overview of Ethylene Biosynthesis and Signaling Pathways in Arabidopsis and Environmental Factors That Modulate Ethylene Signaling EBF2 PMC9547606__F2 Platelets, Macrophages, and Thromboinflammation in Chagas Disease PC TF PMC3085710__F4 KEGG Pathway Map () HEL-S-62p F10 PROS1 C4B_2 F2R THBD F8 F9 PROC C4A CR1 SERPINC1 PLAT C9 A2M SERPIND1 F2 F3 C7 F11 SERPING1 MASP2 SERPINA1 TFPI PLAUR PLG MASP1 KLKB1 C3AR1 CPB2 CD59 F5 C6 F7 CR2 SERPINF2 PMC5997273__F1 Road to Crohn’s disease ATG16L1 EIF2A MYD88 PMC8636012__F1 Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies HK2 FASN GLS PMC4901515__F1 Cilia-mediated signaling pathways whose proper regulation is dependent on the proteasome and the structure of the proteasome PDGFRA SUFU SMAD2 APC SHH SMAD4 SMO PMC11789227__F3 Therapeutic potential of SOX family transcription factors in osteoarthritis HMGA2 SIRT7 ELF3 SFMBT2 CXCR4 CXCL12 LIN28A SIRT1 SOX9 PSMD11 PMC155638__F3 Hypoxic activation of apoptosis pathways BAD APAF1 PTEN PMC155638__F1 MAP kinase signalling pathways ATF2 RHO ETS2 MEF2C CDC42 PMC3993959__F3 Bioinformatic analyses expose alterations in nucleic acid binding and regulatory proteins CHERP SARNP SAA1 CCNC RBM22 PMC8871586__F8 Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation TMOD1 TPM1 ACTN2 TPM3 DES TTN DMD HEL-S-108 MYOM1 TCAP HEL-S-273 MYBPC3 HEL113 ACTN4 PMC7539288__F6 NAD+ deficits in aging-associated dysfunction and cancer HEL-S-26 NAMPT FOXO1 PMC9362381__F4 Thrombosis leading to acute abdomen in corona virus disease- 19:A case series VCAM1 VWF ACE2 PMC10744232__F3 Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis IL1R1 RPS6 TNF MTOR STAT3 PMC7539288__F1 NAD+ metabolism and its physiological function NAPRT NAMPT HEL-S-90n NNMT NNT SARM1 PMC7539288__F2 Subcellular equilibrium of NAD+ ME1 HEL-S-26 NMNAT1 NADK NMNAT2 HEL-S-44 NNT NMNAT3 ME3 PRX PMC7867045__F3 Genetic alterations leading to HIF activation in GB EGF EGFR MDM2 PTEN PMC3043094__F3 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach PLN BCR CAV3 CAV2 PMC7089929__F4 Distribution of differentially expressed genes (DEGs) of the cell cycle pathway (dre04110) in diploid and tetraploid states in vitro and in vivo PLK1 CDK2 DBF4 RAD21 CDK7 PCNA SKP2 MYT1 PMC3043094__F4 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach CD14 NLK NGF MAX MAFK FLNA GRB2 TNF TRAF2 MEF2C JUN BAP1 PMC3043094__F2 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach DCT TYRP1 PMC5663837__F4 ErbB signaling pathway and its circRNA-related genes EGF NRG3 OS9 BAD BRAF EGFR UBE2G1 MTOR WFS1 CRKL ERBB4 AMFR BTC ATF4 SRC JUN UBE4B MAN1A2 BAX ABL2 SEL1L UBE2G2 CASP12 NRG2 SHE SKP1 HBEGF NRG1 RBX1 PIK3R3 UBQLN1 ERBB2 NPLOC4 GRB2 TGFA NRG4 PMC3135646__F1 P53 pathway in development, cancer, and reprogramming ATM MYC MDM2 BMI1 ATR BAX PMC11516169__F9 CsEVs in promoting malignant proliferation and metastasis of CCA cells CDK2 CCND1 CDK4 CCND3 CDK6 PMC3049961__F8 Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR PLCG1 EGFR SDC2 STAT5B CDK7 PRKCA NEDD9 GJA1 PKP4 SRC SHB MAPK1 TNS3 CDK3 PXN PMC7672634__F1 Ingenuity pathway analysis of FGF/FGFR pathway suppressed by cordycepin in MA-10 cells MAPKAPK2 HGF GRB2 CRK STAT3 PMC9249506__F10 Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response PLK3 ATM BCL2 BAX PMC5133671__F8 Simplified model for how AhR mediates the RANK/c-Fos signaling axis of osteoclast differentiation and bone resorption COX3 COX1 AHR NFATC1 CYB ND4 PMC1383550__F2 Two branches of the class I PI3K pathway GSK3B PTEN TF CDC42 PMC9297732__F6 Multi-pronged anti-cancer activity of PI3KD inhibition in cancer BCR BCL2 CD40 PMC7710361__F5 Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders KYNU ABAT PMC8633417__F2 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis TLR4 MYC SMO MYD88 TNF PMC8633417__F1 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis IL18 NOS2 TNF MUC2 STAT3 PMC11869728__F1 Canonical TGFB/SMAD and Wnt/Beta-catenin signaling pathway SMAD2 APC LRP5 SMAD6 SMAD4 LRP6 PMC9438347__F14 Plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/Beta-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model TH GSKIP APC GSK3B LRP5 CCND1 LRP6 PMC1779520__F3 Signaling pathways activated by serum and GF treatments SOCS2 SOCS3 SPRY4 SPRY2 GADD45B DUSP5 PTPRO PITPNC1 GRB2 SRC JUNB YWHAG SOCS5 STAT3 PMC5705586__F3 Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression SMAD2 TGFBR1 SMAD4 PMC4959856__F6 VNN1 expression and function can be regulated by Ox-LDL to promote atherosclerosis NPC1 VCAM1 ABCG1 ABCA1 VNN1 PMC2804818__F5 A summary of the ligand-mediated control of TRP53 expression via the PI3 kinase/AKT/MDM2 pathway PI3 PMC7567487__F2 Mammarenavirus life cycle CD63 NPL TFRC NRP2 PMC8886606__F2 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook CD14 BTK TANK TRADD TRAF6 JAK3 MYD88 JAK1 TRAF2 TIRAP PMC2990745__F1 Examples of pathways shared by a signature hub from the Wang dataset and a signature hub from the Desmedt dataset CD14 RPL17 RPS13 RPS25 EPO RPS17 GCK RPL26 RPS7 RPL9 RPS29 RPL34 PMC8886606__F1 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook CXCR3 IL1B PMC6121189__F6 Prolactin-driven signaling pathways via the short or long prolactin receptors GRB2 CCND1 PRL PMC4711587__F3 De Novo Assembly and Characterization of Early Embryonic Transcriptome BAMBI NLK SOST GAS1 ZIC2 PMC8150799__F4 Physiological and Pathological Inflammation Induced by Antibodies and Pentraxins TBK1 CRP SYK TNF IL1B PMC7784492__F3 Pathways affected by mutations NF1 CDK2 CDK4 FGFR4 PTEN STAT3 PMC3264379__F9 Proposed model for regulation of HCV replication mediated by the Ras/Raf/MEK pathway STAT2 IRF9 TYK2 JAK1 PMC8804383__F7 Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition SMAD2 IL1B PMC6230569__F4 miRNAs modulating dendrite morphogenesis converge ARHG LIMK1 MIB1 SOX2 PUM2 ARHA RAC1 BDNF PMC2587303__F1 mTOR inhibition as a Therapeutic Strategy in the Management of Urologic Malignancies TSC2 RICTOR TSC1 SMAD2 RHO MTOR IRS1 RHEB PMC4383161__F2 Integration of the 3 major pathways that regulate skeletal muscle mass GSK3B MTOR PCNA PMC5995256__F5 Pathways altered in brain metastases compared to primary NSCLC TSC2 BAD TSC1 HEL-S-28 GRB2 CDC37 PTEN EIF4E MCL1 RHEB PMC11047590__F1 Redox systems involved in microglia NLRP3 GPX4 KEAP1 SLC7A11 HEL-S-64p TXNIP RBX1 PRX PMC11047590__F2 Redox regulation of immunometabolism in the polarization of microglia in DR TLR4 NGF FES PTEN MTOR RHEB PMC3966620__F1 Cl− channels in cardiac myocytes CLCA1 CFTR PMC3778395__F1 Plant tetrapyrrole biosynthetic pathway FECH UROD UROS HMBS CPOX POR PRX PMC11506738__F3 Key pathways of COVID-19 vaccine-induced adverse immune reactions TH MRGPRX2 APC PMC11506738__F4 Various mechanisms of adverse immune activation by COVID-19 vaccines TLR8 CGAS TLR7 TLR9 IRF7 IL13 PF4 IRF3 IL4 IL5 TNF IFNG PMC5679221__F2 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia FYN IGF1 HEL-S-28 GRB2 RAC1 MTOR CDC42 PMC5679221__F1 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia FYN HEL-S-28 ARHA RAC1 CDC42 PMC6566438__F7 Some of the signaling pathways involved in the differentiation of ADSCs into IPCs IRS1 GLP1R STAT3 PMC8355044__F1 Functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy TLR4 EGFR CD44 VEGFA ARHA MTOR PEG3 PMC6875034__F6 STRING analysis of integrin signaling pathways and response to wound healing pathways MYOF MYH9 CD9 ITGB3 HEL-S-30 FLNA EGFR EHD2 FLNB HEL-S-7 SERPINE2 HEL-S-102 CD59 MYL12A ANXA2 FAP S100A8 HEL114 ITGAV ACTN4 P2RX4 CD36 PMC9556788__F7 Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs C1QBP LRRFIP2 GOLPH3 RPS7 PYGB POR C9 AP1S1 MASP2 CFP SDHB SRP68 IARS2 SUCLG1 CLTC ACLY TNFRSF17 UBE2L6 CP EIF4A2 HEL-S-62p KIF1B MYO1C TRIM21 C4A VPS36 SEC23B C1QA FH SOCS4 RPS6 FKBP4 GDI1 TNLG1B DENND4C ATP10B EHD2 NAPA CACYBP C1QB ACADL UBE2V2 AK3 HEL-S-115 C4BPA KIF21A FCRL6 MARS1 CARHSP1 TMIGD1 SYT2 LYPD8 PMC8616071__F1 Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors ME1 ATM RRM2 RAD51 CDK4 ERCC1 CDC2 CCND3 BRCA1 CDK6 PMC9095352__F7 Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism SUFU PTCH1 SHH SMO PMC5070718__F1 Levels of miR-146a and miR-146b are regulated by innate immune signaling TLR4 IRAK1 CCL20 TRAF6 CCL5 CARD10 TLR3 STAT3 PMC5378112__F1 Genetic model of the insect melanin biosynthesis pathway () TH DDC AANAT PMC6820234__F1 Heme biosynthetic pathway and experimental porphyria models ABCB6 FECH AIP UROD MPO DDC UROS HMBS CPOX ABCG2 PMC4380839__F1 ROCK and Rho LPA PMC3998841__F2 Inflammatory cytokine-associated idiosyncratic drug hepatotoxicity as a “network toxicity” CASP6 TNF BAX PMC3767467__F4 Proposed model of TRP47 effector function in E FYN PCGF5 PMC8657105__F5 Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 “CREATE” Trial SET ERBB2 MSH6 MSH2 PMC7872968__F7 Phagosome maturation pathway, (B) RIP1 and ECSIT signaling pathway, (C) arachidonic acid metabolism pathway, and (D) cytotoxic T cells signaling pathway using CD226 and PVR axis IRF9 EEA1 TRAF6 ECSIT TNF MAP3K7IP1 TRAF2 FADD PMC7872968__F8 RIG-I signaling pathway TBK1 TRADD NLRX1 TRAF3 TRAF6 IRF3 TRAF2 FADD MAVS PMC8716783__F2 Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways APC MTOR FADD PMC7872968__F5 HIF-1 signaling pathway and (B) relaxin signaling pathway in lungs MMP2 MMP9 EIF4E HIF1A MTOR STAT3 PMC7872968__F6 IL-17 signaling pathway IL17RA TRAF6 RALB ARF6 IL17RC PMC7188829__F5 DEGs enriched in TNF (A), PI3K-AKT (B) signaling pathway during A BAD FAR1 MEI1 BCR TRADD EBP MDM2 RAC1 FADD CD19 PMC4239617__F10 Proposed mechanism/model for the rationale of treatment with a combination regimen of GCs and IFNA in HBV-infected cell STAT1 MAT1A GC PMC4222351__F4 P-21 activated kinase (PAK)1 in canonical and non-canonical NFKB signalling PAK1 TLR4 RELA RELB RAC1 CDC42 PMC8470495__F1 Promising Biomarkers of Radiation-Induced Lung Injury: A Review HMGB1 IGF1 VTN IGFBP7 MTOR PMC6955834__F4 Intermittent fasting‐mediated pathways that induce adult hippocampal neurogenesis HES5 NOTCH1 BDNF PMC10297110__F5 The effects of inhibiting TGFB signaling pathways on hCECs in vitro ECD SMAD2 RHO MTOR PMC6210224__F11 IFN-λ3 rescued the RIG-I signaling pathway STAT1 IFIT3 OASL IFNL3 STAT2 IRF7 RIGI IFNL1 IRF3 TRIM25 MAVS PMC6199328__F8 TEdeff-induced immunotherapy resistance STAT1 JAK1 CASP8 FADD STAT3 PMC8818883__F4 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis TNF TRAF2 FADD ITCH PMC3745214__F1 Targeting TGFB signaling in cancer SMAD2 SMAD6 SMAD4 TRAF6 RHO TF PMC8818883__F5 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis DERA ARC ELL MAL PMC8770568__F1 Therapeutic targets identified in clinical and pre-clinical studies for ESR1 mutant breast cancer IGF1R IGF1 CDK4 MTOR CDK6 PMC8818883__F6 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis LBP CD40 IRF3 CPO PMC8818883__F7 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis CD14 STX7 TLR4 MPO MARCO TUBB VAMP3 HEL-S-99n CD36 PMC3745214__F4 Targeting TGFB signaling in cancer SMAD2 SMAD4 TF PMC8764032__F4 Proximity ligation strategy for the genomic reconstruction of microbial communities associated with the ectoparasite Caligus rogercresseyi ACAD8 ACADS HMGCL IVD DLD MCCC1 DBT HSD17B10 PMC314152__F7 LMP1-induced canonical and noncanonical NFKB activation IRAK1 CXCR4 RELB REL TRAF2 PMC5697452__F6 Mechanism by which MMP-9 regulates formation of focal adhesion junctions EGFR CD44 SRC PMC11640812__F2 Crosstalk relationships between signaling pathways JAK1 MTOR PMC11523861__F1 Dietary Sources of Tryptophan and Main Pathways of Tryptophan Degradation (a) Tryptophan, an essential amino acid, is commonly acquired from dietary sources such as turkey, eggs, cheese, tofu, seeds, and fish ASMT HAAO HEL-S-90n KYNU KMO AFMID AANAT PMC11523861__F2 Tryptophan Sample Collection, Detection Methods, and Biological Functions Samples for tryptophan detection are typically obtained from blood specimens, cancer tissues, and cancer cell lines BCR CD40 PMC6196929__F1 Possible signaling mechanisms of SERM actions in neurocognition and neuroprotection EGF IGF1 BDNF PMC2896874__F11 Schematic overview of MAPK-regulated processes that are thought to couple light to the SCN clock during the early night EIF4E JUNB PER1 PMC9677642__F7 Identification of crucial genes and metabolites regulating the eggshell brownness in chicken FECH UROD SLC25A38 UROS HMBS CPOX ABCB10 ABCG2 PMC9530249__F2 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis NLRP3 TLR4 IL33 CD36 PMC9530249__F3 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis NLRP3 TRIM13 NOD1 ATF4 EIF2A GSK3B UNK NOX4 TRAF2 XBP1 IL1B MAVS PMC3855043__F5 IPA pathways of ChIP-Seq-based NSRF target genes in ESC TBP GRB2 PMC6438767__F7 Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling RICTOR SIRT1 FOXO1 PMC6600375__F6 TGFB mediates metastasis MMP10 ANGPTL4 MMP21 PMC4034110__F1 Mitochondrial and metabolic checkpoints of T-cell activation and apoptosis signals PLCG2 CAD PMC6932957__F7 Hypothesized pathway of mitochondrial apoptosis activation induced by HEV infection NOX4 IL1B VIP PMC5620223__F7 EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer EGF NODAL SMAD2 EGFR SMAD4 PMC4134689__F2 Therapeutic strategies to target mutant NRAS: Direct targeting strategies include inhibition of RAS transcription by RNA interference and blockade of posttranslational modification by farnesyltransferase inhibitors NRAS CDK4 PTEN MTOR CDKN2A PMC6600375__F1 TGFB/SMAD and non-SMAD signaling SMAD2 SMURF2 GRB2 SMAD4 ARHA MTOR SMURF1 TRAF4 CDC42 PMC11523861__F3 Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer SLC7A5 KYNU AHR KMO AFMID PMC6600375__F2 TGF-Beta-induced growth inhibition and apoptosis SMAD2 BIK SMAD4 TRAF6 PMC11523861__F5 Molecular Mechanisms of Tryptophan Metabolism in Digestive System Cancers (a) Tryptophan metabolism plays dual roles in digestive system cancers, promoting or suppressing tumor growth SLC7A5 CDC20 AHR MPO MYC IFNG PMC9694461__F1 New Therapeutic Trend: Natural Medicine for Ameliorating Ischemic Stroke via PI3K/Akt Signaling Pathway AGA PLLP TNF MTOR FADD PMC9305908__F1 17Beta-Estradiol Concentration and Direct B2-Adrenoceptor Inhibition Determine Estrogen-Mediated Reversal of Adrenergic Immunosuppression BAX BOK PMC6102727__F7 Schematic overview of LATS1/YAP/RHAMM pathway and the regulatory effects of LATS1 in the LATS1/YAP/RHAMM pathway KLF5 LATS1 MTOR PMC6869463__F6 Schematic showing the role of CNPase/Notch signalling pathway in modulating EMT and fibrosis SMAD2 SMAD4 PMC2835842__F1 HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways RNASEL TLR9 TRAF6 IRF3 MYD88 TLR3 PMC5226503__F4 Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma ALDOB SHMT1 HEL-S-304 ENO2 PCCA HEL-S-51e TKTL2 RPE HK2 HEL-S-68p PMC9696821__F6 Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics HEL-S-30 HEL-S-87p HEL-S-68p PMC5374583__F7 Survival and proliferative effects of AOF extract on RSC96 Schwann cell BAD IGF1R IGF1 CCND1 PMC2693384__F2 Regulation of Vascular Permeability by Sphingosine 1-Phosphate PAK1 APC RAC1 GIT2 CAD PMC3038250__F4 PI3K/Akt and RAS/BRaf/MEK pathways are frequently altered in melanoma BRAF PTEN AKT3 PMC7258707__F7 Potentiating immune response by activating TLR signaling pathways.With the exception of TLR3, all TLRs activate MyD88 dependent pathway which leads to NFKB mediated proinflammatory cytokine upregulation TBK1 CD14 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TLR3 TIRAP PMC9658955__F8 LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial–Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway EGF EGFR PMC8540886__F2 Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment APC PRF1 CD80 LAG3 SRGN PMC9179421__F1 Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells CPT1A TEC HK2 GLS PMC12152662__F1 Regulation mechanism of PD-L1 in cellMultiple transcription factors directly modulate PD-L1 expression through distinct mechanisms EGF HGF BRAF EGFR MYC PTEN HIF1A MTOR IFNG STAT1 IRF-1 STAT3 BRD4 PMC12152662__F2 PD-L1 in the ALK oncogenic signaling pathway in NSCLCThe EML4-ALK fusion protein enhances PD-L1 expression by activating downstream signaling pathways, including ERK, AKT, STAT3, and HIF-1A (24) ATF3 MTOR PMC6035094__F3 An overview of the cannabinoid type 2 (CB2) receptor system and its therapeutic potential TBK1 TANK TICAM2 TRAF3 TRAF6 IRF3 MYD88 TNF TLR1 MAP3K7IP1 MAP2K6 RARA TLR4 TIRAP PMC9572342__F10 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA RPRM APAF1 TP73 BAX PMC3737462__F2 Accumulation of monocytes/macrophages in adipose tissue and liver, and activation in the tissues TLR4 KLF4 IL1B PMC3442742__F1 NGF signaling pathways in mediating neurotrophic and nociceptor effects.Notes: NGF signals through the high-affinity TrkA and low p75NTR receptors NGF TRPV1 PMC2435278__F2 The Aedes aegypti Toll Pathway Controls Dengue Virus Infection TH MYD88 TUB FADD PMC6047740__F2 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? DAAM1 ARHA ROR2 RAC1 ROR1 PMC3735683__F3 From Genetics of Inflammatory Bowel Disease Towards Mechanistic Insights DUOX2 NCF4 NCF2 PMC6047740__F5 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? CDK5RAP2 PLK1 APC GSK3B NEK2 CEP164 PMC9462662__F2 Relationship of alpha-synuclein to mitochondrial dynamics and quality control PINK1 OPTN SNAP29 PMC5644195__F13 Agents that affect the Hippo pathway (Nat Rev Cancer DICER1 AMOT APC SCRIB LATS1 RHO PTEN LATS2 TRIO PMC6722120__F4 BC subtype-specific EV protein kinase networks IKBKB SI MAPK3 GSK3B FGFR3 PAK4 MAP2K2 FGFR4 RAF1 MTOR EPHA2 ARAF PMC6682198__F8 Schematic mechanism of apoptosis in ovarian cancer and some current targeted molecular therapeutic approaches NAIP TNF MTOR GATA4 PMC9116921__F2 Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways AHR SMAD2 TGFBR1 GSK3B SMAD4 SIRT1 SIRT3 PMC4457513__F2 Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage CUL5 LIMK1 VLDLR MAP1B GSK3B DAB1 CDH2 CRK CDC42 PMC6193731__F3 ROS accumulation induced by fungicidal drugs HEL-S-11 HEL-S-44 CMA1 PMC8792817__F1 Metabolism and Health Impacts of Dietary Sugars XYLB KHK PMC3524319__F6 Construction of the regulatory networks associated with the selected genes using IPA® database IFIT3 IFIT2 CCR2 MHC2TA FCGR1A SOCS3 CCL2 MX2 IFNG PIM1 GBP1 LCP2 OAS2 SERPING1 SERPINA1 IL10RA PSMB9 FGL2 IRF-1 TRAFD1 IRF7 IRF8 FBP1 CXCL10 DECR1 IL6 S100A9 TNF CTSZ CXCR3 IL15 CD72 IL2RG RELA CREM CD40 LITAF SMPD1 IL15RA PLEK IFI35 PSMB10 SOCS1 IFIT1 CASP4 PSME2 PMC3138766__F6 JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients SOCS3 STAT5B STAT3 PMC5154753__F2 Pathways activated following binding of the TSLP cytokine to its receptor complex JAK1 TSLP PMC1774275__F5 Mitogenic signals are transduced by Ras which inhibits the retinoblastoma (Rb) protein allowing E2F and Myc to promote cell cycle progression BAD MYC MDM2 PTEN BAX PMC1774275__F4 The chromosomal instability (CIN) pathway (see text for details) LEF1 APC PMC1774275__F1 Simplified diagram of the Wnt/APC pathway APC CCND1 PMC6240956__F3 Foamy phagocyte polarization follows a triphasic pattern IL10 IL16 IL6 ARG1 IL1B IFNG PMC4612627__F3 Simplified model of a cell signaling process highlighting the flow from signals generated externally by epidermal growth factor (EGF) to the activation or repression of transcription EGF EGFR MYC PTEN PMC1774275__F2 Intrinsic, or mitochondrial, pathway (after Danial and Korsmeyer) BAD DIABLO BAX PMC1375233__F5 Two signaling pathways of TLR in myeloid DCs CD14 TLR4 IRAK1 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TLR3 MAL PMC6775198__F1 Role of Wnt Proteins in T cells FOXP3 PMC1375233__F2 Association between human TLRs and adaptors determine each TLR-specific signaling pathway TLR5 TLR7 TLR4 TLR9 ATF2 TRAF6 IRF3 MYD88 TLR3 TIRAP MAL PMC3978635__F1 mTOR pathway and actions TSC2 TSC1 PTEN MTOR PMC6775198__F2 Immune exclusion through the Wnt/beta-catenin pathway CCL4 IL6 IL1B FOXP3 PMC3978635__F2 mTOR-dependent pathways and inhibitors TSC2 TSC1 PTEN MTOR PMC4547497__F2 Signaling pathways associated with CLRs on dendritic cells PDC CARD9 BCL10 SYK PMC2659592__F7 Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor A2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells PC IL13RA2 IL13RA1 LPA PMC6775198__F3 Effect of WNT signaling on cancer immunosurveillance BATF3 CCL4 TF FOXP3 PMC5857409__F4 Proposed potential therapeutic targets in Erythroleukemia EPOR ALK CHP2 PMC2651172__F7 Possible site for alcohol-induced inhibition of muscle protein synthesis TSC2 TSC1 EIF4E MTOR RHEB PMC8457986__F3 Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease NLRP3 BAD KEAP1 ATF4 PMC4048572__F8 Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy ULK1 IGF1 ATG12 FOXO3A HDAC2 PTEN DKFZp686F0183 HDAC1 SIRT1 PMC8286568__F5 Bacterial alginate metabolism: an important pathway for bioconversion of brown algae PDC APP IPP PMC7442787__F7 Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused PPP4R2 SUFU PTCH1 PMC7652989__F1 Sphingolipid biosynthetic pathway in plants and the inhibition of this pathway by FB1 opn SPHK1 HEL-S-5 PMC4746004__F4 Collateral Lethality: A new therapeutic strategy in oncology HEL107 RPE PMC4383600__F2 Interplay between multiple factors in the transforming growth factorB (TGFB) signalling pathway and the control of muscle mass BAMBI GDF5 SMAD2 SMAD4 MSTN SKI SMAD1 DKFZp781O1323 PMC2705117__F3 Role of peroxisome-proliferator-activated receptor B/D (PPARB/D) in gastrointestinal tract function and disease COX2 ANGPTL4 APC CCND1 RXRA PMC4071223__F7 Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis ARHA MYD88 TLR1 SMURF1 MAL PMC10854888__F1 HSP in biochemical functions of cells HEL-S-62p BAD TLR4 ATG14 BAX PMC9413412__F1 Crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 DPP4 MAPK14 SLC3A2 POR PMC10758458__F2 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer KEAP1 ABCC1 ABCC5 ABCG2 ABCC2 PMC10758458__F3 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer PHLPP2 PTEN RAC1 CELF2 ID3 FOXO1 PHLPP1 PMC9380331__F7 Structure and character analysis of cotton response regulator genes family reveals that GhRR7 responses to draught stress PRR9 HK3 ELF3 PRR12 COPE CRY2 ELF4 HK2 PRR3 PMC4189230__F1 Process and mechanisms of blood vessel formation PDGFRA SMAD2 SRC PMC3143902__F1 Inhibition of myostatin (MSTN) and activin signalling by the soluble activin type IIB receptor (ActRIB) ALK SMAD2 PMC10758458__F1 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer TSC2 BAD TSC1 EGFR MDM2 GRB2 PTEN EIF4E MTOR PMC6436762__F9 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K PLK1 ECT2 FOXM1 CDC2 PMC3964957__F6 Pathway diagram customization is available via the web interface, and lets the user control many aspects of the pathway diagram FER PROC PMC11029991__F7 Bioinformatics-based discovery of biomarkers and immunoinflammatory targets in children with cerebral palsy: An observational study FLCN IRF9 GFAP GSK3B LRP5 RNF152 LRP6 PTEN IL6 RHO EIF4E MTOR DEPTOR RHEB MLST8 RICTOR GRB2 IL2 TYK2 JAK3 SLC3A2 JAK1 GRB10 SKP2 PMC5918238__F3 Non-bilayer phospholipids in mitochondrial structure and function PGS1 PGP PSD2 PMC6362586__F4 Associative gene network describing interactions between three central genes/proteins of the extrinsic apoptotic signaling pathway biological process NGF BAG3 SNAI2 PTEN TNF DIABLO BRCA1 SIL1 BMP4 TNFSF6 IL7 FYN ENSA TRAF1 TIMP3 BCL2 MCL1 RNF34 EN1 TGFB1 ASL PMC6436762__F1 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K TSC2 BAD PTEN EIF4E MCL1 IRS1 RHEB INSR PMC8809485__F2 Gaucher Disease: Basic and Translational Science Needs for More Complete Therapy and Management TBK1 NLRP3 RIPK1 TFEB RIPK3 IL1B RHEB PMC11504183__F1 BMP concentration on fate of ectodermal cells to induce epidermal, placodal, neural crest, and neural derivatives SHH SIX1 HES1 PMC11504183__F2 BMP signalling pathway and modulators during development of pre-placodal ectoderm TWSG1 BMP2 SMAD4 BMP7 SMAD1 DKFZp781O1323 BMP4 PMC9199383__F2 Neutrophils in COVID-19: Not Innocent Bystanders TBK1 CGAS TLR9 RIF1 STAT2 IRF9 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 STAT1 NLRP3 TLR8 TLR7 TYK2 JAK1 ACE2 PMC2950451__F3 Metabolic flux distribution through branching areas of the central metabolism of MG1655 and ECOM4LA cell lines GIP CIT MAL PMC7405837__F8 DEGs in RPE cells of the cholesterol synthesis pathway SQLE PMVK MVD DHCR7 FDPS FDFT1 SC5D DHCR24 MVK HMGCS1 MSMO1 HMGCR PMC5876234__F10 Lico A-mediated Nrf2 signaling pathway protects APAP-induced ALF via inhibition of mitochondrial dysfunction and apoptosis MAF GCLM KEAP1 GCLC APP PMC3742697__F8 Proposed model of Cr(VI)-induced carcinogenesis LEP GSK3B MTOR PMC7868402__F6 LncRNA H19 regulates the gene pathway of osteogenic differentiation through the lncRNA-miRNA-mRNA network (; ; ; ; ) RUNX2 HDAC5 PMC7405837__F6 DEGs in RPE cells of the sugar metabolizing pathway PGM2 PHKA1 GYS1 AGL PYGM PMC7405837__F7 DEGs in RPE cells of the glycerophospholipid metabolism pathway PCYT1B BTD CDS2 LPA GPAM HMFN0839 GPAT4 CDS1 PC GPAT2 AGPAT3 LPIN1 CEPT1 ACACB PID1 LPCAT4 CHPT1 PCYT2 PLA2G2A PTDSS2 PNPLA2 GPD1 PMC7405837__F4 DEGs in RPE cells of ATP-producing pathways PDHA2 AIP PDK2 PDK4 IDH3B ZNF183 NDUFA3 PDK3 ACO2 COX11 SUCLA2 OGDH SDHD SDHA PMC7405837__F2 DEGs in RPE cells of the circadian rhythm pathway CRY1 RORC CRY2 ETV6 MYF6 BHLHE41 NR1D2 NR1D1 PER2 PRKAB2 PER3 PMC7868402__F3 Regulatory effect of methylation levels of bone metabolism-related genes on bone formation (; ; ; ; ; ; ; ; ) RUNX2 BMP2 SOST PMC7868402__F4 Illustration of SIRT1 signaling pathway in bone remodeling (; ; ; ; ; ; ) SOX2 RUNX2 SIRT1 PMC5391975__F3 Signaling networks activating the canonical RAF-MEK-ERK signaling pathway and that have been involved in SCLC metastasis (see text) HGF CXCR4 FGF2 CXCL12 PMC4970276__F8 Model deciphers molecular mechanisms by which PRMT5/p44 controls cell growth ERBB2 ERBB3 GLIPR1 BTG2 PMC3679380__F5 Extranuclear and nontranscriptional effects of RA and vitamin A RARA SRC PMC7211317__F8 Schematic model for the ability of RTR-1 to induce cell cycle arrest and apoptosis ATM STAT3 BAX PMC7564532__F4 Hypothalamus-pituitary-gonad (HPG) axis in vertebrates and related molecular pathways GNRHR NPY AgRP TAC3 FSHR LHCGR GAL PRL PMC9179555__F4 Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease TSC2 MTOR PMC2992886__F3 Genes associated with autoimmunity regulate the CD40/NFKB signaling pathway TRAF1 CD40 TRAF2 PMC4874354__F8 Glycolysis HP HEL-S-162eP PMC8176995__F3 Can Some Anticancer Treatments Preserve the Ovarian Reserve? KIT LIF PTEN RPS6 BMP4 PMC7170511__F16 Models for RHAMM-regulated motogenic signaling in keratinocytes and temporal-spatial coordination of keratinocyte and fibroblast migration in excisional wounds MMP9 EGFR CD44 PMC3826850__F1 The Drosophila Toll and Imd pathways DEAF1 REL FADD PMC2491602__F6 TNFA signaling pathway TRADD TRAF2 FADD PMC6895844__F6 Network and pathway analysis of shared networks between AD and T2D CSNK2A1 SENP6 MYC MAP1LC3A RPL9 EIF3S6IP NCK1 RPL31 EIF3E BCLAF1 PSMC6 MDM2 UBE3A NCL SET CAND1 BRCA1 HLA-B LSM3 CALM1 RPL17 PAN2 GABARAPL2 CDKN1A CDC5L WASL VCAM1 GRB2 TNFAIP3 IFIT1 EIF4A2 HEL2 DDX1 EGFR SNRPG ITGA4 LY96 ARGLU1 CD81 DKFZp686L0365 ISG15 ELAVL1 ERBB4 RYBP BASH APP GABARAPL1 YWHAG RPS15A CBX3 DEK PARP1 HUWE1 EED SIRT7 SNRPE SMC3 COPS5 TNFSF10 HEL-S-93 FADD TARDBP PMC6895844__F7 Network and pathway analysis of shared networks between advanced AD and T2D PIK3R1 MAPK8 AKAP11 HEL-S-1 GSK3B MYC SFPQ MAPK14 TRAF6 EIF2AK2 NUDT21 SMARCA5 FGFR2 BCLAF1 SNW1 EN1 PRKAB1 SNCA CAND1 DDB1 BRCA1 HLA-B RXRA CALM1 YWHAQ PPP1CC VCAM1 GRB2 PPP2CA VCP CLASP2 SUMO2 TBL1XR1 USP15 HEL2 NR3A2 HSP90AB1 UBR5 EGFR PPP2R1A RYK ITGA4 MOV10 CCNC ELAVL1 SOCS4 APP CDC2 MED1 TIA1 OTUD4 YWHAG SOX2 RPA1 NUP160 CDC37 RAC1 HDAC1 PS1TP5BP1 MORF4L2 CACYBP SIRT7 KAT2A ERBB2 COPS5 LYN SYK RAF1 SMC4 HEL-S-93 TARDBP PMC6669704__F1 Prostaglandin biosynthetic pathway COX2 PTGIS COX1 PMC5788649__F1 Gene master regulators of papillary and anaplastic thyroid cancers PPP3CA PPP3CC MAPK3 MYC CAPN10 DFFA CASP9 MAPK1 PRKAR1B BAK1 TCF7L2 DDB2 CASP10 HRAS RET CDKN1A TNFRSF1A BCL2 MAP3K14 AKT3 CASP6 IKBKG CHUK BAD BRAF TPM3 TPR CCDC6 DFFB TFG BIRC3 BAX GADD45G POLK MAP2K2 IKBKB CASP3 BIRC2 NFKBIA LEF1 MAP2K1 DCP2 NFKB1 RELA PIK3CA CCNJ TRAF2 PIK3R2 PDCD1 PMC7016469__F6 Cyclooxygenase 2 (COX2) promotes ovarian cancer cell proliferation and invasion via the prostaglandin E2 (PGE2)/ nuclear factor-kappa B (NFKB) signaling pathway PTGER2 COX2 MMP2 MMP9 STAT3 PMC4316382__F2A BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells MMP10 SOX2 ECT2 SMO PMC1828403__F1 Representation of TLR4-signaling through the MyD88-dependent and MyD88-independent pathways TBK1 TLR4 STAT2 IRAK1 IRF9 TRAF6 IRF3 TYK2 IFNAR2 MYD88 JAK1 IFNAR1 PMC4742202__F5 Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development MUC4 ERBB2 PIK3CA GATA3 CBFB PMC2947987__F3 Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions CLPS RP1 LBP MSRA PMC11604654__F4 Two signaling pathways that Fish oil and Forskolin involved23–25 COX2 BMP6 BMP15 LDLR FSHR STAR INSR PMC12174911__F1 Cross-regulation of ferroptosis and immunogenic cell death in tumor microenvironment HMGB1 GPX4 MPO PMC12174911__F2 Comprehensive schematic diagram of cross-regulation of ferroptosis and immunogenic cell death STAT1 FACL4 SLC7A11 PMC2663527__F1 The formation of leukotrienes (LTs) through the 5-lipoxygenase pathway of arachidonic acid metabolism, and the effects of LT inhibitors in different contexts LTA CRP LTB PMC9702548__F7 The effects of HFPGE on the immune response in RAW 264.7 cells CXCL10 TRAF6 TNF PMC8431791__F2 Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases RHO CDC42 PMC8017335__F2 IL-1 family cytokines regulate NK-cell responses ATF2 STAT4 IL33 PMC8017335__F3 Type 2 cytokines show diverse effect of NK cells activation STAT4 STAT3 PMC3666258__F5 Diagram of norrin as a multifunctional ligand for three receptors/binding proteins BMP2 BMP4 PMC7728369__F7 Proposed model illustrating mechanisms of USP39 regulating the proliferation, apoptosis and metastasis of non-small lung cancer cells via regulating the p53 pathway MMP2 MMP9 PMC10534927__F3 Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives TBK1 CGAS CS VCAM1 CRP PMC9063567__F1 Altered Cholesterol Homeostasis in Huntington’s Disease CYP27A1 CH25H CYP46A1 DHCR7 DHCR24 PMC4316382__F1A BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells BOC SUFU SMO GAS1 PMC9360899__F1 PI3K/AKT signaling pathway in gallbladder carcinoma EGFR DMBT1 PTEN SP1 PMC10871146__F1 Hydrogen maintains an anaerobic environment in the intestine and reduces oxidative damage via selective antioxidant effects MPO ATF4 EIF2A XBP1 PMC4409470__F2 Nutrients, Foods, and Colorectal Cancer Prevention COX2 NR1i1 HEL-S-11 INS PTH BAX PMC9360899__F2 PI3K/AKT signaling pathway in gallbladder carcinoma PTEN BAX PMC5944465__F3 Quantum dots in cytotoxicity NLRP3 APAF1 TRAF6 MYD88 PMC2494582__F1 Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus GC AQP2 RHO PMC5209388__F1 Tetrahydrofolate (THF) synthesis, C1 metabolism, and triacylglycerol (TAG) biosynthesis in plant cells PC DHFR PAH PMC6557086__F6 L-Norvaline, a new therapeutic agent against Alzheimer’s disease RET NGF GDNF MTOR SPHK2 SYP PMC10649278__F6 Diagram of IL-17 signaling pathway TH FRY COX2 TRADD FADD PMC4714141__F4 Pathway of miR-7 in hepatocellular carcinoma HOXD10 EGFR MTOR CCNE1 PMC9010204__F3 Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis TLR4 SMAD2 SMAD4 NOX4 MTOR STAT3 PMC10623083__F7 CFH knockdown suppresses the stemness of breast cancer cells through regulation of the EPB41L3/MAPK axis SOX2 EPCAM NHS CFH CD44 CD24 PMC5833577__F4 Necroptosis signaling by TNFR1 stimulation via TNF RIPK1 TRADD RIPK3 TNF FADD MLKL PMC5135332__F6 Reconstruction of purine biosynthetic pathway in C PFAS ADSL HEL-S-70p PMC5833577__F3 Signaling pathways of neutrophil necroptosis RIPK1 TRADD RIPK3 TNF FADD MLKL PMC11839971__F11 circ0066187 promotes pulmonary fibrogenesis through targeting STAT3-mediated metabolism signal pathway CDK2 DPP4 FGF2 CCND1 COL6A1 STAT3 PMC2212850__F2 Major signaling pathways for type I IFN gene transcription TBK1 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TNF TLR3 PMC4714141__F1 Pathway of microRNA-7 in gastric cancer IGF1R GC EGFR MTOR PMC4714141__F3 Pathway of microRNA-7 in colorectal cancer MMP2 MMP9 EGFR CCND1 YY1 BAX PMC8198407__F3 Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies DHFR MTRR MTHFD1 PMC9312970__F9 Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway GCLM TLR4 GSDMD PMC4791278__F3 Ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells CKS2 ATM DKFZp781B1423 BRCA1 PMC9535683__F3 Cytoskeletal dysregulation and neurodegenerative disease: Formation, monitoring, and inhibition of cofilin-actin rods VASP ARHA RAC1 RANBP9 SGK1 SSH1 CDC42 PMC8435905__F1 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features CYP46A1 AMACR H1-3 COA1 CYP7B1 HSD3B7 CYP27A1 SI DBP LBP SLC27A5 EHHADH LAT PMC8435905__F3 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features CYP27A1 CYP46A1 CYP2R1 CYP3A4 CYP7B1 LAT CYP7A1 HSD3B7 PMC7218026__F6 Schematic presentation of the ACLY PIP2 binding region and the novel Lyn/Src-dependent tyrosine phosphorylation sites LYN SRC ACLY PMC4177877__F1 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis GSK3B SMO PMC4177877__F3 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis SIRPA CD47 PMC7720970__F1 Revisiting Hormonal Control of Vascular Injury and Repair PTCH2 PTCH1 SMO PMC5853294__F1 Metabolic pathways for TAG biosynthesis in green algae PC PMC8403061__F6 C-Type Natriuretic Peptide Plays an Anti-Inflammatory Role in Rat Epididymitis Induced by UPEC CNP COIL IL1B PMC4391155__F5 The PVT1 functions MYC NOP2 PMC4487016__F2 Amino acid sensing in yeast and mammals at the vacuole or lysosome NPR2 NPR3 SLC38A9 WDR59 SH3BP4 WDR24 RHEB PMC11898294__F6 Enhanced CTL responses in TNBC via MUC1 mRNA nanovaccine and anti-CTLA-4 therapy MUC1 NPS CTLA4 PMC4487016__F3 Molecular architecture of the SEA complex NPR2 NPR3 DEPDC5 WDR59 WDR24 PMC11898294__F7 CD8+ T cell-enhancing nanovaccines for cancer treatment IRF7 IRF3 TNF PMC7185212__F2 CD8 T cell linear differentiation model RUNX3 APC CCR7 IL2 FOXO1 IFNG BATF PMC6047740__F6 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? NODAL PITX2 APC RPGRIP1 RHO CELSR3 FOXJ1 WDPCP CELSR2 PMC11898294__F3 Types and mechanism of nanovaccine adjuvants CGAS CXCL9 TNF IFNG PMC4531834__F2 Extrinsic cell death pathway is typically triggered by members of the tumor necrosis factor (TNF) family of death receptor ligands, comprising TNF itself, Fas ligand, and TNF-related apoptosis-inducing ligand (TRAIL) TRADD CYLD TNF TRAF2 FADD MLKL TAB3 PMC6888741__F2 DUB family members USP4 USP26 USP15 USP2 USP33 USP20 USP11 USP9Y USP18 USP16 USP14 CYLD USP9X USP6 USP1 BAP1 PMC6888741__F3 Hippo signaling pathway ANKRD1 NF2 AREG LATS1 RHO LATS2 PMC6888741__F4 DUBs and their role in Hippo signaling OTUB2 OTUD1 USP21 AMOT VGLL4 USP9X LATS1 USP11 LATS2 YOD1 ITCH PMC11898294__F1 T-cell activation, immune suppression, and therapeutic strategies in the TME CD27 TNLG8A HEL-S-92n CD80 HMOX1 PMC8918930__F10 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway TH REL PMC5127022__F3 A diagram of host factors involved in MeV inducible stress granule formation and autophagy ELF3 ATG12 IRGM EIF2A GOPC TIA1 MAVS BAX PMC4844344__F12 SIG5 expression control in the light-signaling pathway regulating the expression of the chloroplast genes psbD and psbA for the photoreaction center II core proteins D1 and D2 in response to light intensity and quality CRY1 CRY2 RFWD2 PMC4695848__F1 Functional role of deubiquitinating enzymes in autophagy USP15 USP33 USP20 USP35 USP36 RALB USP30 PMC6288913__F1 HCV life cycle and involved Rab proteins EGF RAB11A CLDN1 RAB27A EGFR RAB23 RAB7A RAB3D CD81 RAB1B LDLR EPHA2 RAB8B RAB32 RAB13 PMC8649520__F1 Bioinformatic analysis of transcriptome data sets for aortae obtained from aged ApoE −/− mice fed a high‐fat diet revealed 50 overlapping genes that are enriched for ER stress‐ and UPR‐related pathways PIK3R1 VAPB HEL-S-89n EIF2AK2 TMEM33 XBP1 APOE BAX BOK PMC8649520__F7 Schematic summary detailing the distinct UPR pathways regulated by hypercholesterolemia and aging within aortic and lung tissues in a murine model of atherosclerosis ELF2 ATF4 APOE PMC8651359__F7 Exploring the Therapeutic Mechanisms of Huzhang–Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking SRI KY FEV TES TRO DES MAL PMC4979440__F8 Role of EtOH-mediated cytotoxicity and neuroinflammation in context to HAND via cPLA2signaling in human astrocytes COX2 CXCL8 IL1B CYP2E1 PMC2651582__F1 Metabolic reprogramming in tumor cells CPT1A HK2 FASN PMC2788154__F1 Signaling pathways that lead from activated KIT and aggregated FcERI to mast cell responses STAT1 KIT BTK LAT2 GAB2 VAV1 LYN GRB2 SRC SYK LAT STAT3 PMC3417476__F1 Cyclic AMP-mediated induction of Treg cells and suppression of effector T cells CSK LCK FOXP3 PMC5516276__F4 Genes uniquely modulated in Fam13a−/− mice are involved in carbohydrate, lipid metabolism, and molecular transport network CTSK TES MEIS1 TMPRSS4 ZNF521 SLC30A7 ANTXR1 MRPL9 WNT3A CD177 MEN1 DAP3 MRPL12 CSF1 PECAM1 PMC3163944__F7 Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice CD14 EGF FLNA NTRK1 ATF2 EGFR RASA2 PRKX MAP2K2 SHOC2 TNF DDIT3 MAX GAB2 GRB2 JUND DUSP2 NTRK2 MEF2C PTPN5 PMC9499665__F1 Could BMPs Therapy Be Improved if BMPs Were Used in Composition Acting during Bone Formation in Endochondral Ossification? RUNX2 HOXC8 SMAD4 DLX5 MAP3K7IP1 SP7 PMC5516276__F3 Genes uniquely modulated in Hhip+/− mice are involved in the connective tissue development and function network NPPB HSD11B1 NPPC FGFR4 PCSK5 KCNE2 TACSTD2 ALOX15B CNPY4 NPR3 GIPC2 OSBPL3 CHAD MAPK1 BHLHE41 CLDN5 EMCN ACAN EMP1 PMC8524061__F5 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy FGF21 FYN ATF4 SMAD2 GSK3B MDM2 SIRT1 PMC8524061__F1 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy GRB2 SHE DAP SRC PMC4397736__F1 Metabolic loops increase pathway multiplicity PIG59 PGM2 ENO2 HFE GLCE PMC4397736__F2 Comparison between simulations and MFA experiments CS MALL CIT PMC7564852__F3 Schematic depicting the molecular mechanism of co-activators involved in TCF/LEF-dependent Beta-catenin transcriptional activities and their functional consequences MMP2 FOXM1 SATB1 MYC TRIB3 CCND1 TCF7L2 DKK1 EZH2 GPR49 AXIN2 HDAC1 PMC8143357__F4 Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering BMP2 SMAD4 SMAD1 DKFZp781O1323 PMC7564852__F4 Schematic representing the molecular mechanism of transcriptional repression in TCF/LEF-dependent Wnt outcomes APC DACT2 BCL9 LATS2 PMC3544722__F9 Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase BAD MDM2 BAX PMC7564852__F5 Chromatin modifiers involved in Beta-catenin-dependent transcriptional regulation and their roles in the Wnt pathway KDM1A ARID1B KDM4D SETDB1 HDAC2 TRRAP EZH2 HDAC1 DOT1L SIRT1 ARID1A PMC8323716__F1 Aberration of EZH2 signaling in cancer PIK3IP1 NOTCH1 DDB2 RORA STAT3 PMC7337081__F1 Modular Organization of Cis-regulatory Control Information of Neurotransmitter Pathway Genes in Caenorhabditis elegans ChAT BAGE ACHE ACE2 TF MAPDA PMC4142723__F2 SIRT6 as a master regulator of glucose metabolism SIRT6 JUN TF PMC6390351__F8 Schematic representation of TLR and JAK-STAT pathways postulated in the slug I TRAF3 TRAF6 ECSIT MYD88 TRAF4 PMC3097943__F1 Role IL-6 signaling in CCA inflammation-related epigenetic regulation NF2 EGFR MAP3K8 JAK1 STAT3 PMC8998991__F4 Mammary Gland: Basic Structure and Molecular Signaling during Development NRG3 DDR1 IGF1R HGF AREG TBX3 EGFR GSK3B PTH RHO ID1 PRL ADAM17 BMP4 STAT1 IGF1 HEL-S-11 PRLR GHR GATA3 STAT3 PMC8583405__F7 Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway ULK1 SOX2 ATG12 PMC4002295__F1 Schematic presentation of the rationale of targeting PARPs for cancer therapy BRCA2 SSB BRCA1 PMC4809369__F2 LIF/JAK/STAT3 signaling pathway in mouse ESC self-renewal PIM1 SOX2 SOCS3 GBX2 LIF TBX3 GRB2 STAT3 PMC6549576__F2 ERK signaling pathway was hyperactivated in the patient's tumor tissue PIK3R1 DDR1 BAD EGFR PRKAR1A MYC ATF1 CACNA1A CSF1R COL4A6 HEL-S-76p PTK2B SRC HMGN1 JUN ELK3 KIT PDGFRA FOS NTRK1 RET RAP1A ZAP70 GRB2 LAT ADCY9 PMC7564852__F1 Wnt canonical (Beta-catenin-dependent) pathway ZNRF3 RNF43 APC LRP5 LRP6 GPR49 TF PMC4345324__F8 G-protein-coupled receptor controls steroid hormone signaling in cell membrane ADRBK1 USP1 PMC11015710__F2 Rosacea: Pathogenesis and Therapeutic Correlates MMP2 MMP9 TNF PMC4323172__F1 Both ligands and receptors are single-pass transmembrane proteins composed of different structural domains EGF RBPJ ADAM10 FURIN PMC3608206__F4 Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate EGF SOX2 SOX3 LIF SOX11 SHH STAT3 PMC4809369__F6 Activin/Nodal signaling pathway in human ESC self-renewal NODAL SMAD2 PMC4809369__F3 Canonical Wnt/Beta-catenin signaling pathway in mouse, rat and human ESC self-renewal LEF1 TCF3 CDX2 APC ESRRB LRP5 LRP6 KLF2 CDX1 PMC4809369__F4 FGF signaling pathway in mouse, rat and human ESC self-renewal FGF4 FRS2 GSK3B GRB2 PMC4151534__F2 IL-1A and IL-1B synthesis and signal transduction pathway IRAK1 TRAF6 IL1R2 IRAK4 MYD88 CSA2 IL1B PMC3691915__F8 Regulators of mitochondrial biogenesis and function LPL TG NDUFB6 IRS1 FOXO1 CD36 PMC7378170__F1 Possible mechanisms through which major metabolic pathways contribute to the milk fat globule (MFG) size development in the mammary epithelial cell PC TG PSD PEMT PMC8235708__F1 Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications HEL-S-90n IL16 IDO2 IFNG PMC6386897__F4 MiRNA-gene-pathway interactive map PIK3CD FOXO4 FOXO3A MAPK7 MAPK3 MAPK14 NRAS PRKAA1 PTEN RRAS2 HRAS FOXO1 PRKCA RAC3 RASGRP3 PIK3CA JUN PLA2G10 AKT3 PMC8193257__F1 Progress of Breast Cancer basic research in China BTN3A3 CCR5 USP15 SETD4 EGFR TSPAN8 CCL5 CCL18 PROCR IL1B PTX3 PMC8193257__F2 Progress of Breast Cancer basic research in China NAMPT FOXF2 TEAD4 CCL2 MTOR POU2F2 BMP4 PMC6834480__F2 NKG2D/NKG2DL interaction activates NK cells ZAP70 GRB2 SYK PMC3865866__F8 The FBXL2- and PTPL1-dependent regulation of the PI(3)K pathway PTEN IRS1 PMC3742550__F3 Intracellular 1-carbon metabolism (simplified), emphasizing pathways relevant to the text TH MTR AHCYL1 DHFR MTRR TYMS MTHFD1 PMC9310545__F1 Signaling pathways producing pro-inflammatory cytokines NLRP3 IRF7 SYK IRF3 TNF AIM2 MAVS GSDMD PMC7246017__F3 Complement activation and vasculopathy in coronavirus disease 2019 (COVID-19) VWF ACE2 PMC3187613__F5 Signaling pathways that regulate mammalian autophagy TSC2 BAD TSC1 PTEN UVRAG RHEB PMC7305712__F2 Metabolic liver disease in diabetes – From mechanisms to clinical trials INS INSR PMC6884041__F1 Neutrophil immunometabolism in cystic fibrosis NLRP3 SP1 IL1B PMC2939720__F1 Viral hijacking of the host ubiquitin system to evade interferon responses TBK1 TANK TLR9 STAT2 IRF7 IRF9 BST2 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 ISG15 TLR7 TYK2 JAK1 PMC6834480__F5 Strategies for targeting the NKG2D/NKG2DL axis for cancer immunotherapy MMP14 MMP2 ATM ADAM10 ATR ADAM17 PMC6770832__F1 Map of potential pathways and their potential interactions activated by a soluble factor- radiation-induced bystander effect (RIBE) signal TRADD TGFBR1 IL6 MAP3K7IP1 CDK6 COX2 TRAF5 CDK2 MDM2 JUND CDK4 TRAF2 PCNA TAB3 PMC5288579__F10 Group I Paks as components of the Ncad/Cdo signaling pathway PAK1 CDH2 CDC42 PMC11938789__F7 The role of ZBTB6 in BC proliferation ZBTB6 STAT3 PMC5336479__F5 Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines using TMT 10-plex Isobaric Labeling ERBB4 PCTK1 ERBB2 CDK2 ERBB3 GRB2 RAB9A MTOR PIK3R3 SHC1 IRS1 CDC42 PMC6770832__F6 Hypothetical signalling pathway that illustrates how the various pathways in this review may be connected, which is partially informed by preliminary research FOXO3A TGFBR1 TGFB1 BAX PMC9095530__F2 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation TRADD RIPK3 TNF FADD MLKL STAT3 PMC8508555__F4 Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential MAF KEAP1 SFN NQO1 PMC3197649__F6 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes CDK5RAP2 MRPL44 ARHH AP2A2 FGF8 PLCG2 RB1 BIRC7 ABCB11 STK24 FGFR2 UNC45A CTDSP1 PTK2B ZNF592 SNW1 PTMA KIAA0513 TGFBR3 DDT IMMT FBP2 SPRED1 SDC2 CBX1 TRAF5 WASL TP73 NEFL WWOX INCA1 RUNX2 CHD3 PTPRS RIPK1 MNAT1 CCNB1 ZBTB16 hEMMPRIN UBE4B RBL2 EPHA4 KIT IDH3B HAX1 SMAD9 PRMT1 PELP1 KIFC3 EPHB2 PMC10541724__F7 Schematic illustration showing that CSSC-EVs mediated the LESC phenotype by regulating the Notch1 pathway through miRNAs NOTCH1 HES1 PMC3197649__F3 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes KIF23 CCNA2 FBXO5 BIRC5 NBN ATAD2 TINAG SRC ZHX2 KCNK15 POLR1C CENPA IFI16 TP53RK ELMO1 ANAPC7 MAPRE1 PLEKHM1 ZHX1 CDCA8 AURKB CDC20 HEL-S-80p MCM2 CEBPZ CDK2 KPNA2 HEL113 TERF1 CDT1 NEFL FOXM1 COL3A1 BLM PARD6B HEL-S-104 PAG1 EIF2S2 CHEK2 PRC1 PTPN1 CCND1 PRKDC PTTG1 CCNE2 MYBL2 BMP7 RRM2B COPS5 CCNB2 HEL-S-93 CYCS PMC8826423__F1 Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification MMP7 AGO2 CXCL1 APC CCND1 GPRC5A PMC9609612__F9 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 HMGB1 IRF3 RORA OTUD3 SIRT1 MAVS PMC9095530__F6 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation CASP3 RIPK1 TRADD MTCH2 FADD BAX PMC9124578__F3 Origins and roles of osteoclasts in bone development, homeostasis and repair CSF1R SEMA4D SEMA3A WNT16 SOST LRP5 LRP6 PMC2854308__F1 Signaling complexes induced by TNFA to mediate NFKB activation, apoptosis and necroptosis TRADD CYLD TRAF2 FADD PMC3824536__F1 Druggable Drivers of Lung Cancer FGFR4 PMC11356883__F4 Outline of the DTSAs biosynthetic pathway in Dendrobium species BCAT2 C17orf95 PMC7434719__F1 Diagrammatic presentation of conserved domains of MUC2, MUC6, MUC5AC, and MUC5B MUC5AC MUC6 MUC5B MUC2 PMC3493930__F8 Mechanisms by which AP-1 transcription factor regulates LY6K expression, which activates the ERK signaling pathway to mediate cell invasive motility and metastasis in human breast cancer cells LY6K GC PAX3 PMC7465197__F2 Number of transcriptional factors positively or negatively regulate ARF transcription E2F2 TBX2 SMAD2 EGFR MYC BMI1 EZH2 PMC11314424__F3 Diagram summarizing the effects of salidroside (SAL) on cellular signaling pathways BMP6 BMP2 SMAD2 BMP7 PMC9523165__F1 Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review IGF1R IGF1 PTEN IRS1 FOXO1 PMC5528296__F2 PI3K signalling regulates both choline and glucose metabolism TIGAR MYC PTEN MTOR PMC4975451__F8 PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide BAD PTEN PMC5923349__F1 Hippo signaling pathway in Drosophila and mammals LATS1 LATS2 PMC8859461__F1 Type-I Interferon Signaling in Fanconi Anemia FAN1 GIG8 FANCD2 FAAP24 FANCM FANCL FANCA FANCB FANCE FANCG PMC5923349__F2 Hippo signaling pathway and the anti-neoplastic immune response IL10 CXCL1 CXCL5 IL8RB CCL2 CSF1 PMC11274826__F6 Osteopontin: A Key Multifaceted Regulator in Tumor Progression and Immunomodulation CD163 FAP CXCL9 CD200 CDH2 PMC5923349__F3 Hippo signaling immunomodulatory functions CXCL1 NLRC4 IRAK1 SETD7 IRF3 IRAK4 CXCL2 MYD88 IL6R PMC11274826__F3 OPN in the regulation of various signaling pathways BRAF ATF4 ZEB2 EGFR HIF1A MTOR STAT3 PMC5923349__F4 Leukocyte-intrinsic Hippo pathway functions BCR LPL CCR7 ARHA HEL-S-92n LATS1 CD19 RAB13 FOXP3 PMC11274826__F4 Diagrammatic representation of multifaceted function of OPN in various tumors SOX21 HEL-S-28 ATF4 EGFR GSK3B CD44 CSA2 CDH2 MTOR HEL-S-133P PMC6927982__F7 Predicted pathway illustrated that IL1B and MALT1 were significantly upregulated in the NF-kappa B signalling pathway COX2 IRAK1 TRAF6 IRAK4 MYD88 PMC6562915__F2 Illustration of the main signaling pathways activated upon Ang2 binding to endothelial cells FYN FES RAC1 FOXO1 PMC4546937__F2 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING IL13RA2 IL13RA1 STUB1 PMC4546937__F3 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING TSC2 TSC1 SOCS3 JAK3 JAK1 DEPTOR SOCS5 SOCS1 RHEB MLST8 PMC7103888__F2 Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders USP4 USP33 TRAF6 MYD88 SLIT2 USP48 USP18 STAT1 USP12 USP14 CYLD USP46 USP9X ROBO1 USP36 USP22 SLIT1 PMC3160087__F7 Model of the role of the Nodal and Cripto signaling pathways in mouse XEN cell differentiation NODAL CRIPTO SMAD2 SMAD4 PMC8400201__F1 Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin MTOR ATG14 PMC7969609__F9 MAPK signaling pathway CD14 TRADD DAO FLNA MIP MYD88 TNF NLK MAX FRK ECSIT RAF1 TRAF2 MEF2C PMC8403172__F7 The proposed regulatory mechanism of ARRB1 in this study ATF4 EIF2A TNF PMC8621917__F2 Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention BAD GSK3B MTOR STAT3 PMC8125972__F1 Impact of Epigenetic Modifications in Myeloid Malignancies HEL-S-26 NPM1 ASXL1 NRAS EZH2 FLT3 EZH1 SUZ12 TET2 GATA2 PMC3913902__F4 Induction of NLRP3 inflammasome complex by the inorganic crystal HZ NLRP3 LYN SRC SYK TXNIP PMC2360674__F8 Schematic of porphyrin-synthetic pathway to illustrate potential control points for increased PpIX accumulation CPO PMC8520510__F4 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma SOCS2 KDM5B SMAD2 MYC NRAS BMI1 TNFSF13 RB1 HIF1A E2F3 SOX9 SOX4 CDK6 FYN DFFA BCLAF1 ZEB2 SPTBN1 ITSN1 SMO MSH3 SP1 KIF20B FLII SET ITGB3 HBEGF RBX1 IRS1 NEDD9 PPM1D DHFR BCL2 ZNF547 RREB1 ROCK1 TGFBR2 HDAC11 YES1 ADAM17 MACC1 PIM1 TLN2 IL10 HEL-S-30 RPA1 MYOCD KLF5 ARHA RAC1 IFNB1 CFTR CD40 PRPF38A PPP3CA ATP1B1 CBFB DICER1 LMNB2 ACVR2B WNT4 MDM2 PKLR HDAC2 MCM10 CDH2 BMP1 ERG HEL-S-28 CDKN1B FXN VEGFA PTPN13 ROBO2 EIF4E IL23R BRCA1 PREX2 HMGA2 MCM2 KLF4 CTNND1 ITGAV GPC4 IGF1R BRAF RTKN PAK4 HRH1 SOCS7 CCND1 FZD7 CDK4 MTDH HOXA10 SP7 CD47 SOX2 ADD3 NFATC1 MAD2L1 WNK1 SENP1 CD44 NRG1 IL6 ITGB1 NID1 ITGB8 SRGAP1 NRP1 ABCC1 CAMK1D SCN5A ARF6 BNIP3 PXN PMC8520510__F6 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma SMAD2 GSK3B SMAD4 STAG1 DBF4 CDK7 CDC45 STAG2 ORC2 MCM2 SMC3 CDK2 CYC1 PCNA SKP2 PMC4676172__F2 Wnt/Beta-catenin signaling and directly related pathways affected by genetic-driven and/or gene expression activation or suppression in primary and/or recurrent tumors of 4 HCC patients SFRP4 PIN1 HEL-S-28 APC LRP5 CD44 HCCS LRP6 CDKN2A MAP3K7IP1 WIF1 SOX9 SOX4 NLK MMP7 MDM2 SRC SOX6 TCF4 PMC7436103__F7 lncRNA target pathway network in AGPS-silenced U251 cells MIA PMC9075737__F2 Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension? EGR1 MMP2 MMP9 LCN2 PTEN SP1 PCNA PMC7436103__F5 Signaling transduction and pathway network of co-expressed lncRNAs and mRNAs in AGPS-silenced U251 cells EREG ENPP1 IGF1R EGFR CXCL8 IL1R1 CCL2 MTOR NME3 SHC3 CCR1 TLN2 opn PANK3 COL1A2 DCTPP1 THBS1 CXCL14 JUN IL1B CREB5 ANGPT2 NAMPT PRKAA2 FGF2 CD44 UGDH AK4 GYS1 TLR3 HEL-S-125m SDC4 IQGAP1 PIK3CA PXN JAM2 AKT3 PMC6642076__F1 The complement system, showing approximately 50 directly involved soluble and membrane-bound complement proteins HEL-S-62p PLG MASP1 MBL2 C4A CR1 C9 C1QA VTN CRP C7 C6 C1S PMC11790539__F2 Pyroptosis signaling pathway MTOR GSDMD DFNA5 PMC7940950__F2 Four genes (RAC2, CXCR4, CXCL2, and CCL18) were significantly enriched in the chemokine signaling pathway ITK RER1 BAD SHE ARHA DOCK2 CRK BAP1 PMC4859220__F3 Poor tumor T cell infiltration CXCL1 CXCL10 CXCL9 ATF3 CCL4 PMC3679547__F1 Canonical pathway analysis IL1F10 SCARB1 PLG ABCG8 MSR1 ABCG5 IL6 LPA HMGCR TNFSF14 CXCR4 PTPN11 LDLR CXCL12 APOE STAT3 PMC6333895__F6 Cell migration elicited by chemotactic GPCRs via the GBG–P-REX1–Rac pathway is mainly mediated by Gi over Gq or G13 because of the tight control that GAq and GA13 subunits exert on GBG CXCR4 RGS2 RAC1 LPA PMC12202350__F11 The molecular mechanism underlying EM-2 inhibiting the proliferation of LC and BC cells ATM BAX PMC6792490__F7 Colorectal cancer pathway enriched in KEGG CASP3 EGF BAD POLK ERG SMAD2 APC MSH6 CASP9 MTOR JUN BAX PMC8584291__F1 Senolytics: A Novel Strategy for Neuroprotection in ALS? BAD APAF1 CDK2 CDK4 FADD CDK6 BAX PMC4859220__F4 Scientific rationales of potential therapeutic combinations with PD pathway blockade APC CXCR4 CCR4 CD40 CTLA4 TIGIT LAG3 CXCL12 TNF CCL22 PMC5397509__F1 Central role of RTA in reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) from latency leading to lytic cycle PML PIN1 NFIB SSB IRF3 SP3 STAT3 PMC4993636__F4 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network AMOT HEL-S-28 SRC RHO LIMD1 PMC4993636__F2 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network PATJ MOBP AMOT PMC5986855__F3 Downregulation of VRK1 by DRAM1 in the autophagic pathway induced by p53 and deactivation of p53 by phosphatases and ubiquitin ligases the proteasome in DNA damage response DUSP4 ATM DRAM1 MDM2 VRK1 PMC5210567__F4 KEGG pathway maps for (A) non-small cell lung cancer (hsa05223) and (B) EGFR tyrosine kinase inhibitor resistance (hsa01521) RARA NF1 FHIT BAD HRG DAO ERBB2 EGFR CASP9 PTEN AXL BAX PMC8002743__F6 Detailed schematic models representing changes in cellular processes with CdSe/ZnS QDs or InP/ZnS QDs in the budding yeast PMC9547189__AF1 miR21 modulates the Hippo signaling pathway via interference with PP2A BB to inhibit trophoblast invasion and cause preeclampsia LATS1 PMC7378891__F4 Canonical Type I IFN and non-canonical JAK1-and IFNAR2-independent IFNB signaling pathways STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 TNF IFNAR1 IFI27 PMC10495361__F5 Joint analysis of Chinese yew seed transcriptome, proteome, and metabolome EIF2S1 CDA PIG59 CS SKP1 EIF4E UHRF1 RPS15 HPSE CYP1A2 MLST8 ETF1 MAP2K1 ADA APRT ADK PMC10495361__F6 Summary diagram of specific metabolic pathways involved in Chinese yew seed germination FDPS FDFT1 LPP GGPS1 RPE HEL60 PSD SDHA PMC12180913__F5 PI3K/Akt signaling pathway in cell migration PTEN RAC1 CDC42 PMC12180913__F6 TGFB/Smad signaling pathway in cell migration MMP3 SMAD2 MMP9 SMAD4 ARHA CDH2 PMC12180913__F7 Wnt/Beta-catenin signaling pathway in cell migration MMP7 MMP2 APC MMP9 LRP5 LRP6 RAC1 CDH2 PMC4396743__F7 Proposed model of signaling pathways activated in primary NHP microglia in response to B TLR5 TLR4 CXCL8 CCL2 MYD88 TLR1 TNF NOD2 PMC5758607__F8 A schematic for TMZ resistance induced by SCD1 mediated the activation of Akt/GSK3B/Beta-catenin signaling axis GSK3B PMC3561517__F8 Overview of the recruitment and modification of PCNA and Pol D by RNF8 involving different DNA damage pathways RNF8 RAD18 PCNA PMC11790539__F5 Ferroptosis signaling pathway GPX4 SLC7A11 ETV4 PMC8161134__F1 Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome? DHFR PMC11790539__F6 Cuprotosis signaling pathway FDX1 ATM RPL3 PMC2643336__F3 From the diet to the nucleus: Vitamin A and TGFB join efforts at the mucosal interface of the intestine STAT3 FOXP3 PMC11790539__F3 Necroptosis signaling pathway RIPK1 TRADD MLKL PMC11790539__F4 Autophagy signaling pathway BRAF ATG3 FOXO3A RBM47 MTOR DKFZp686F0183 PMC8238154__F8 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells CXCL1 NRF NRF1 NUPR1 FOXM1 PCSK7 CX3CL1 CDKN2C DPP4 SMAD2 BACE2 CXCL8 CCL2 CDKN2A CEBPG CITED2 CEBPD MMP7 AHR PDGFA ATF4 MDM2 NOTCH1 EZH2 BTG2 PPRC1 NOTCH2 SS18 MAFB WWC1 CTSK ING1 IRF9 ATF3 IRF3 FOXO1 ID3 NFKBIA NFKB2 FHL2 RORA CCL22 PPARG SMAD1 MLL2 PMC3348964__F1 Metabolic pathway for disulfiram in humans CS MOS CYP3A4 WAS PMC6547757__F10 Impact of flight condition on expression of crystallins in the network of proteins associated with ophthalmic disease as defined by Ingenuity Pathway Analysis (IPA, https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis) RBM38 CRYBA1 PA2G4 RPP14 HEL-S-101 RING1 POLR2H EIF4E TUSC2 PHF6 MAF UBTF MAPK12 EP300 PC4 NIFK CRYBA4 RMND5A PMC8238154__F9 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells HLA-DPA1 PLA2G6 HLA-DOB FPR2 HLA-DRB1 IL12RB1 HLA-DOA HLA-DMA HLA-DPB1 HLA-DQB2 HLA-DRB5 HLA-DQA1 CXCL9 CCL19 CCL22 HLA-DMB HLA-DQA2 PMC3652659__F3 Marginal zone B cells: virtues of innatelike antibody-producing lymphocytes TH CD14 CXCL13 GC CXCR5 CD40 IFNG PMC5741957__F3 Oxidative phosphorelation metabolic pathway NDUFS4 SDHC NDUFS3 CYB NDUFV3 ND6 COPE COX17 ND3 SI ND2 COX10 NDUFA11 COX11 NDUFA10 ND4 SDHD SDHA SDHB PMC12180913__F2 Cell migration and function during normal wound healing HMGB1 HGF CCL2 MVP PMC8238154__F5 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells TGFA IFNG PMC12180913__F4 Rho GTPase signaling pathway in cell migration RHO RAC1 CDC42 PMC8859437__F3 Aldosterone-Regulated Sodium Transport and Blood Pressure EGFR SF1 SRC STAR PMC9501954__F2 P16INK4A—More Than a Senescence Marker CDK2 MDM2 CDK4 CDK6 PMC12109847__F2 AKT signaling pathway is known to be regulated by miR-21 through the targeting and suppression of the tumor suppressor phosphatase and tensin homolog (PTEN) TSC2 TSC1 PTEN RHEB PMC12109847__F3 MiR-21 modulates the MAPK/MEK/ERK signaling pathway directly by downregulating the SPRY and DUSPs that normally suppress ERK activation STAT1 ATF2 GRB2 RAF1 PMC4584352__F1 Anti-oxidative effects of astaxanthin in neurological diseases KEAP1 SP1 NQO1 PMC6044036__F1 Metabolic cycles involved in methionine metabolism SPR MTR PC PMC6044036__F2 SAM treatment during hepatocarcinogenesis APEX1 MYC IL6 PMC9032069__F7 Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGFB/Smad2/3 Signaling Pathway CS SMAD2 SMAD4 SIX1 PMC6073374__F1 Mechanistic target of rapamycin (mTOR) signaling pathway FOXO4 FOXO3A EIF4E FOXO6 DEPTOR FOXO1 RPTOR PMC9310656__F2 Gut Microbiota: A Novel Player in Autoimmune Hepatitis NLRP3 TLR4 TLR9 AHR GPBAR1 IRF3 CYP1A1 IRAK4 MYD88 PMC9273267__F1 Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response GPX4 LPCAT3 STEAP3 ASCL4 SLC7A11 SLC3A2 SLC40A1 TF PMC9096094__F5 Betaine Regulates the Production of Reactive Oxygen Species Through Wnt10b Signaling in the Liver of Zebrafish GSK3B WNT10B PMC7649723__F1 SARS-CoV-2 replication ACE2 TMPRSS2 HEL-S-69p PMC5968842__F9 Schematic diagram of how LIPUS promotes the Schwann cell viability and proliferation signaling pathway GSK3B CCND1 PMC8248532__F8 Cryptotanshinone Inhibits the Growth of HCT116 Colorectal Cancer Cells Through Endoplasmic Reticulum Stress-Mediated Autophagy ME1 ATG12 AGL PMC4523298__F3 Conserved and differential networks for the proteins in the PI3K-AKT kinase pathway between breast and ovarian cancer cell lines computed using a Bayesian FDR set to 0.10 COX2 MCAM EGFR PTEN JUN PMC7409924__F1 Methylene blue may have a role in the treatment of COVID-19 COX2 PLG PMC3703536__F1 Highlights of 10 years of immunology in Nature Reviews Immunology TLR4 TLR9 TRAF6 MYD88 TIRAP PMC4523298__F2 Significant edges for the proteins in the PI3K-AKT kinase pathway for breast (a) and ovarian cancer cell lines (b) computed using a Bayesian FDR of 0.10 MCAM RAB25 PTEN PMC6647277__F5 Curcumin actions on the WNT pathway in cancer therapy BAD GSK3B MTOR STAT3 PMC12181166__F4 mTORC1 signaling pathway showing genes (or rather their gene products) that reached exome-wide significance in black TSC2 ULK1 FLCN TSC1 FOXO3A FNIP2 SIK3 RPS6 MTOR DEPTOR RHEB MLST8 PMC6647277__F6 Beneficial role of curcumin in cancer APC GSK3B TNF STAT3 BAX PMC9021355__F2 Pathological features of tissues and cell populations during cancer cachexia IGF1 FOXO3A SMAD2 LIF F3 IL6 MTOR IRS1 PHGDH FOXO1 PMC8674571__F1 The Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family ACVR1 ACVRL1 BMPR1A SMAD4 TRAF6 SMAD1 TRAF4 DKFZp781O1323 PMC7139812__F1 Pathological implications of amyloidB (AB), reactive oxygen species (ROS), and neuroinflammation and their role in potential therapeutic approaches for cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD) BACE1 ADAMTS13 TXN PMC6073374__F2 Sonic Hedgehog (SHH)/Patched (PTCH1) and WNT signaling pathways APC PTCH1 GLI3 GSK3B SHH SMO PMC3191732__F11 Hydrolytic metabolism of 2-AG and PG-Gs COX1 ABHD12 ABHD6 PMC3703536__F5 Highlights of 10 years of immunology in Nature Reviews Immunology TLR4 TLR9 TRAF3 SYK RAF1 MYD88 NOD2 TLR3 IFNG STAT3 PMC8716463__F1 DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication SSB PARP1 BRCA1 NEIL1 ATM BRCA2 MSH6 RAD51 MSH3 MSH2 ATR OGG1 PCNA PMC8499579__F7 Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer TBK1 CGAS CXCL10 IRF3 CCL5 PMC3178084__F2 Runx2-deficient cells exhibit suppression of genes by insulin at multiple stages of the signaling pathway IGF1R RUNX2 EBP GRB2 LDLR SOS1 PMC7665242__F4 Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial–mesenchymal transition-related signaling pathways HGF EGFR PMC3429538__F5 Highlights from this issue ERAL1 DRAM1 PMC5225396__F1 Possible roles of lncRNAs played in the context of RNA-RNA interactions ADAR BMPR2 ANAPC5 ACVR1 STAU1 ITGB8 TGFBR1 GNB4 PMC6843035__F5 Phosphoinositide signaling pathway in renal collecting duct cells PLCB4 PRKCE P2RY2 PIP5K1C PRKCH PIP5K1A PI4KB PRKD1 PMC3946772__F1 Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes PNPLA3 G0S2 LPA PMC3985519__F3 Down-regulation of the clotting cascade by the protein C pathway APC ARHA RAC1 PMC2819802__F1 Activation of apoptotic and survival pathways by TNF GADD45B TRADD TNF TRAF2 FADD PMC5855617__F1 Cancer-fighting mechanisms of BP SOX2 EZH2 AXL PMC9468722__F3 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review LRAT CRABP2 STRA8 RDH10 ALDH1A2 PMC7412871__F3 Transcriptional Regulators of Ca2+ Homeostasis EGR1 CDS1 BCR SP2 CDS2 RELB SP1 RHD SP3 PMC9468722__F4 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review DAZL DDX4 STRA8 SMAD4 MAP3K7IP1 SMAD1 DKFZp781O1323 TAB3 PMC11565213__F2 PIK3CA gene mutation activation of PI3K/AKT/mTOR signaling pathway will resist the action of anti-EGFR monoclonal antibody on EGFR signaling pathway, resulting in resistance to EGFR monoclonal antibody in colorectal cancer patients BRAF EGFR PIK3CA MTOR PMC9028087__F1 MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD TBK1 TLR4 MYD88 PMC2811176__F2 Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction RUVBL2 CRY1 XPNPEP2 WRNIP1 FGF2 INO80D DHX8 BUD31 RSF1 NOC3L PRICKLE4 CPN1 NR1C1 CECR2 ZNHIT6 MRTO4 SLC35A5 LPIN3 SLC35A1 HNF4A KNG1 TGFB1 SPAST PMC3570673__F6 SIRT1 in the brain is involved in a number of processes that affect neuronal health, neurogenesis, and behavior RARB NHLH2 HTT MAOA YY1 ADAM10 SP1 BDNF HSF1 SIRT1 PMC4770749__F9 BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling CCNA2 CDK2 FADD BAX PMC8789313__F2 Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives PC BCL10 TRIM62 TSLP IL23R NOD2 PMC10743675__F3 Osteobiologies for Spinal Fusion from Biological Mechanisms to Clinical Applications: A Narrative Review MAML1 IHH RUNX2 PTCH1 LRP5 LRP6 SMO SOX9 PMC10743675__F4 Bone morphogenetic proteins (BMPs) signaling pathways PTH1R RUNX2 NODAL SOST DKK1 BMP4 BMPR2 GDF15 BMP8A BMP5 INHBC BMP6 BMP2 APC LRP5 LRP6 PTH MSTN GDF10 PS1TP5BP1 BMP10 INHA GDF11 TGFB1 INHBB INHBA INHBE PMC6361956__F5 Cerebellum (CB)-specific biological processes in Alzheimer’s disease (AD) brain NDN MBP HEL-S-84 NUTF2 GNG10 EDF1 OMG ACADS APP HAGH HEL114 SNX3 EIF4B CAPZB RHOB MAP6 APOE CD47 NCAM2 SVIP CYB THY1 FLOT2 PCP4 NDUFB4 WASL GNAS VCP SNCB COMP HEL107 SYT2 PMC5479827__F3 Regulation network of the lectin genes related to immune activities MYH9 LLGL2 PROS1 AP2A2 ATXN3 IRAK1 CLEC4E HEL-S-130P POLR3E FLOT2 NFKBIA EPN3 MCM5 CLEC16A CDC20 LMAN2 ARHGAP5 CBLC PMC11770925__F4 Components-disease-target gene-pathway network EGFR DPP4 TYMP CCL5 GCG INSR RARA SHBG MMP2 CD209 SRC EPHX2 NOS2 SLC5A2 ADK MGAM KIT HDAC8 IGF2 BMP7 FABP6 TNF PADI4 NR1C1 HEL-S-162eP HEL-S-22 MYH6 CASP3 MMP12 OGA ADA JAK3 EPHA2 PPARG CDC42 PMC7419604__F2 Communication between the GI tract and the brain CCK AHR PYY IL1B PMC6471940__F4 Molecular signaling in cancer MDM2 PTEN HES1 PMC4923163__F3 BDNF and TrkB signaling pathway GRB2 PTEN BDNF PMC10978726__F3 SKP2-p27 axis CDK2 SKP1 SKP2 PMC7996029__F2 Therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma RHO MTOR ARG1 PMC4432743__F8 ERK pathway signaling and outcomes in the M ARG1 PMC3371005__F6 Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster ANK2 PRKCE SDC1 HEL-S-1 TREH GRIP2 EGFR NRCAM IPP RPTOR PLCB1 HEL-S-68p NLK GNA15 POLE HGS LIPG LPL PLCE1 DGKZ RPS27 ALDH9A1 PMC10978726__F4 Involvement of SKP2 in hematological malignanices BCR CDK2 GAB2 MYC GRB2 SKP2 PMC8770806__F2 Applications and Immunological Effects of Quantum Dots on Respiratory System IL33 IL6 CCL2 IL1B PMC11781165__F1 Intestinal bacteria and their metabolites on physical barriers TLR4 CDKN1A APC MYD88 PMC9663828__F6 Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer SMAD2 SNAI2 PMC7702050__F2 RNAi‐mediated regulation of gene expression AGO2 DGCR8 SI DROSHA RAN XPO5 PMC11781165__F3 Gut microbes and metabolites mediate various signaling pathways related to AP progression NLRP3 ATG16L1 NOD1 ATG12 DAP RAC1 MYD88 DKFZp686F0183 NOD2 GSDMD PMC8465798__F7 Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway KRI1 SCAI OST4 INS CP PMC8581311__F7 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment ERBB3 EGFR EIF4E IRS1 PMC7096357__F1 Co-regulation of Hippo and Hippo-like signaling pathways by Mob family proteins MOB2 STK38 LATS2 MOB4 PMC10312956__F3 Networks of the rare-variant genes associated with suicidal behaviors in AI OPRD1 SEMA3A CD34 HIF3A PENK SELL FLT1 KDR STARD5 GJA1 NRP1 SLC5A9 ZNF30 DCTN1 HSD17B3 VEGFB STAR HHEX PMC8581311__F4 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment RET ERG GDNF PMC8581311__F2 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment FGFR1 EGFR PMC3792737__F9 Summary of the interactions identified in this work between Dmrt5 and the secreted ligands and Wnt/Bmp regulated graded transcription factors expressed during early patterning of the cerebral cortex EMX2 NFIB GLI3 CUX2 PMC12167289__F1 Schematic summary of signal transduction mechanism of the canonical Wnt signaling in human cells APC GSK3B LRP5 LRP6 PORCN BCL9 PMC6732511__F2 Optimal management of atypical hemolytic uremic disease: challenges and solutions HEL-S-62p CFHR3 CFHR2 CFB THBD PLG CFH C6 INF2 CFHR1 CFI PMC6219741__F8 The proposed mechanisms of over-activation of UPR to trigger apoptosis EIF2D ATF4 EIF2A ATF3 KDM4B PTEN PMC7468622__F7 TRIM33 affecting renal cancer cell proliferation and EMT through the Wnt/Beta-catenin pathway (requires further experimental proof) CDH2 TRIM35 PMC5828294__F6 The metabolic changes in the liver of fed and fasted HrasG12S/+ mice.(a and b) Changes in gene expression in the liver of HrasG12S/+ mice under fed (a) and fasted (b) conditions ME1 GOT2 HADHB HEL-S-133P GLUD1 ACADM HEL-S-281 GLS PMC5398560__F6 Complement Anaphylatoxins, C5a and C3a, Suppress Interferon-Beta Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway TBK1 BTK DDX41 IRF3 IFNB1 PMC7970221__F1 Bioactive nanotherapeutic trends to combat triple negative breast cancer CDK4 CDK6 PMC3947439__F1 Molecular pathways regulated by PGE2 that are inhibited by aspirin APC EGFR GSK3B SRC MTOR TCF4 PMC8049958__F12 Hypothesis that autoimmune signaling pathways mediate the pronociceptive effects CRPS patient IgM in muMT fracture mice lacking immunoglobulin HEL-S-62p C4B_2 TNF PMC6797978__F6 Schematic representation of the effects of TAGLN2 on breast cancer metastasis MMP2 CXCR4 PMC6815235__F1 Molecular mechanisms that underlies TRPV1-mediated nociceptive hypersensitivity in the dorsal root ganglion (DRG) neurons from a mouse model of sickle cell disease ADORA2B CCR2 CCL2 TRPV1 STAT3 PMC8603508__F1 Noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways ADAR DGCR8 DROSHA TF PMC5548020__F2 Insulin signaling pathway TSC2 BAD PDK2 INS MTOR ACD CRK CPA2 RHEB INSR PMC5287062__F1 Cellular senescence NF1 ATM MDM2 PTEN CDKN2A PMC7706141__F8 PPI network of all DKKs and their similar genes TNFRSF12A PORCN DKK1 DKK2 PARVA FGF20 FBLN5 A2M LDB2 ADAMTS13 F3 APP EMCN ARHGAP29 LYAR STARD8 PRSS23 BMP1 AQP1 DKK3 TRAPPC6A CALU AREG PTH LAMA3 DKK4 MMP14 LAMB1 CD151 CLEC14A TRH GJA4 PMC5714761__F3 Inhibition of stemness and EMT by IL-32θ BMI1 STAT3 PMC6534050__F5 Proposed model relating canonical and non-canonical Wnt signaling with teneurin-3 expression WNT3A GSK3B PMC11012151__F7 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism NRG4 TFAM METRNL PMC6796468__F5 Proposed model of PYCR1 interference on HCC cell proliferation and apoptosis JUN IRS1 PMC9094424__F1 Inborn Errors of the Immune System Associated With Atopy DSG1 CDSN IL33 FLG IL25 TSLP PMC9094424__F2 Inborn Errors of the Immune System Associated With Atopy CARD11 BCL10 ZAP70 WIPF1 DOCK8 ZNF341 IL6ST ARPC1B LAT STAT3 PMC4124796__F1 Signaling pathways of leptin and insulin in the CNS POMC AgRP LEPR FOXO1 INSR PMC8118521__F3 Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling ACTA2 SMAD2 CDKN1B SMAD4 CCL2 TNF MTOR CTGF PMC3920940__F7 Diagram showing the model proposed for the association of EMT, CSCs and the PI3K/Akt/mTOR signaling pathway in CaP radioresistance and the effect of possible action of BEZ235 on radiosensitivity SOX2 CD44 CDH2 MTOR PMC4816188__F1 TP53 pathway in CLL ATM BIRC3 MDM2 RPS15 ATR PMC11012151__F2 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism PINK1 BAD PTEN PMC5010719__F1 MET signaling pathway in IPF GRB2 PIK3CA PMC9180565__F2 Interplay between Mast Cells and Regulatory T Cells in Immune-Mediated Cholangiopathies HRH1 JAK3 IL6 JAK1 STAT3 FOXP3 PMC5867024__F2 Diagram showing the biased activation of CGRP receptors and AM1/2 receptors by ADM2, as well as the downstream signal pathway ADM2 RAMP1 RAMP3 GAA RAMP2 PMC9270311__F2 Effects of Ginsenosides on PI3K/AKT signaling pathway GSK3B FOXO1 HMGCR PMC8321873__F2 Metabolic Strategies for Inhibiting Cancer Development AIP HEL-S-30 F2 ACLY HEL-S-68p PMC9270311__F3 Effects of Ginsenosides on PI3K/AKT signaling pathway GSK3B BCL2 MTOR PCNA BAX PMC3901108__F3 Summary diagram showing the role of ATG16L1 and NOD2 in the autophagy pathway and the defects observed when Crohn’s disease (CD) associated mutations are present ATG16L1 DKFZp686F0183 NOD2 PMC6189458__F2 Map of autophagy induction ULK1 PI3 CAMK4 MAPK14 MAPK1 ATG101 ULK2 MTOR CAMK1 ATG14 RB1CC1 PIK3R4 PMC11480102__F11 Implications of ITCH-mediated ubiquitination of SIX1 on CDC27-cyclinB1 signaling in nasopharyngeal carcinoma CCNB1 CDC27 SIX1 ITCH PMC3957919__F7 Proposed model depicting the role of IFI35 in negative regulation of RIG-I signaling IRF7 IRF3 IFI35 MAVS PMC7877171__F3 Molecular mechanism by which intermittent fasting (IF) affects tumor cell growth NAMPT IGF1 PRDM11 LEPR SIRT3 PMC1481658__F11 Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity POMC PTEN STAT3 PMC5587179__F2 Processing and digestion of engulfed apoptotic cells utilizes LC3-associated phagocytosis and promotes an anti-inflammatory response ATG12 ABCA1 UVRAG PMC5307356__F6 Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites GIG8 ID4 ID1 ID3 PMC6738663__F2 HMGB1, as a priming signalling, involved in the stress-neuroinflammation-mesolimbic dopaminergic pathway NLRP3 HMGB1 BDNF IL1B PMC4156316__F2 Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis FOXM1 GSK3B ARHA PMC6237563__F6 Schematic representation of the downstream targets of the MVA pathway, depicting its various intermediates (blue), end products (green) and functional implications (yellow) ARHA GIP IPP PMC3359833__F2 Linking pathways to disease: Crohn's disease (from Wang et al CXCR3 CCR5 TBX21 CCR6 STAT4 TYK2 RORA IL18RAP IL23R IL12RB1 STAT3 PMC3027010__F1 Schematic review of the molecular mechanisms linking diabetes mellitus and colorectal cancer IGF1 APC GRB2 MTOR PMC8790872__F7 Novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression FOXA1 GSK3B TNF SETD2 PMC5029635__F14 NFKB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression CASP3 TRADD CASP9 IRF3 CCL5 CCL2 CASP8 FADD PMC8640817__F1 Targeting ferroptosis for cancer therapy: iron metabolism and anticancer immunity GPX4 LPCAT3 FACL4 PMC5793760__F4 TGFB signaling pathways SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC11662157__F2 PI3K/mTOR signaling pathway during early T cell development CXCR4 IL7R PTEN MLST8 HES1 PMC7299409__F5 miR-410-3p is induced by vemurafenib via ER stress and contributes to resistance to BRAF inhibitor in melanoma NF1 BRAF TBP EBP ATF2 ATF1 YY1 AXL PMC6090045__F1 Simplified general overview of glucose, fatty acid, and amino acid metabolism in healthy endothelial cells F2 ASNS PMC6771474__F2 Complement system and crosstalk with other innate immune effector systems in liver IRI, regeneration, and transplantation HEL-S-62p CD14 IL1B PMC6383147__F4 Positive feedback linking oxidative stress with enhanced p62 expression, Kelch-like ECH-associated protein 1 (KEAP-1) autophagic degradation, and stimulation of antioxidant enzyme expression MAF TBK1 ULK1 KEAP1 PMC6311524__F1 The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA MTR DHFR TYMS HEL-S-51e MTHFD2 PMC2729932__F2 ES-EB system has made possible the identification of multipotent progenitors for both hemato-vascular and cardio-vascular derivatives NKX2-5 GATA4 ISL1 GATA2 PMC9361353__F4 Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway HEL-S-62p C9 MASP1 C7 C6 MASP2 MBL2 PMC2763047__F3 Fibroblast Growth Factor Receptor Signaling Pathway as a Mediator of Intrinsic Resistance to EGFR-specific Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer EREG AREG FGF2 EGFR TGFA FGF9 PMC11761653__F11 Seq2Hybrid recovers Ilamycin G BGC CS FH AMT HEL-S-5 PMC2763047__F2 The Fibroblast Growth Factor Receptor Signaling Pathway in Non-Small Cell Lung Cancer EREG IGF1R HGF IGF1 AREG IGF2 FGF2 EGFR TGFA FGF9 PMC7690341__F1 Pyrimidine nucleotide synthesis and chemical structure of PTC299 CDA UPRT UCK2 UMPS UCK1 CAD PMC4560835__F1 Recurrent 2,8-dihydroxyadenine nephropathy: a rare but preventable cause of renal allograft failure ADA XDH PNP PMC6313617__F1 Metabolism pathway of capecitabine and 5-fluorouracil (5-FU) DHFR PMC8463266__F8 Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NFKB pathway through microbiota–gut–brain axis COX2 TLR4 LBP MYD88 PMC10887009__F4 MR suppresses gastric cancer development by inhibiting GSCSs RAB37 EGFR DKFZp686F0183 PMC4160635__F1 Genomic aberration of the proliferative and invasive pathways of glioma signalling EGF PTEN RAC1 PMC4293489__F1 Activation of TLR4 by LPS CD14 TLR4 LBP MYD88 TIRAP PMC4293489__F2 Participation of CD14 in TLR4 signaling pathways triggered by sLPS and rLPS CD14 TLR4 MYD88 PMC2919655__F3 Diversity in Post-Transcriptional Control of Neutrophil Chemoattractant Cytokine Gene Expression TRAF6 IL1R1 IRAK4 MYD88 IL17RC PMC4910912__F1 Union of active TF-miRNA regulatory pathway in CDDP resistance FGA MUC1 SNCA KRT19 PTGS2 PARP1 CEBPA CCL2 LIN28A STAT1 HMGA2 BCL2A1 MT2A HBB SLC45A3 SLC3A2 PSMB9 JUN TGFB1 PMC9563287__F1 Richter Syndrome: From Molecular Pathogenesis to Druggable Targets BTK BCR NOTCH1 PLCG2 PMC3967167__F1 Schematic drawing of the PI3K/Akt signaling pathway TSC2 BAD PTEN PMC11214488__F8 GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis HEL-S-133P SGK1 PDPK1 HK2 PMC5402284__F6 Transcriptome profiling of sulfate deprivation responses in two agarophytes Gracilaria changii and Gracilaria salicornia (Rhodophyta) PTS STS GC PMC3967167__F5 PI3K/Akt-mediated mTOR activation positively regulates protein synthesis EIF4E MTOR RHEB PMC7465316__F2 Functional proteins association networks identified by differential proteomic analysis and relative Venn diagrams RPLP2 LMNB2 HEL2 HSP90AB1 HEL-S-269 HEL-S-1 ALB HEL-S-273 HEL-S-100n NUDC RPSA PS1TP5BP1 PMC11711130__F6 SPC enhances Th9 cell differentiation and function by upregulating Smad3, STAT5, and Beta-catenin signaling pathways, mediated by increased mitochondrial ROS SMAD2 CTLA4 LAG3 PMC5574319__F11 Signaling pathway changes triggered by HLJDD and its three principals PI3 IL2 PRX PMC8151284__SF1 Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity COX2 COX1 IRS1 PMC8814716__F8 miR-154-5p Affects the TGFB1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1 SMAD2 SMAD4 SMURF1 TGFB1 PMC9481929__F8 Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin RAC1 PMC11641539__F12 Diagram illustrates the neurotrophic activity of FVSE via activation of the Trk-B receptor in the Neurotrophin signaling pathway NGF GRB2 BCL2 BDNF PMC3310713__F3 Dual nature of Myc induced DDR ATM MYC ATR PMC9180978__F3 Soluble Epoxide Hydrolase and Diabetes Complications NLRP3 TRPV4 VCAM1 ATF4 NOX4 TNF BAX PMC3563272__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT PC PGP INS PSD HEL-S-5 PMC5590227__F1 The STAT3 pathway and therapeutic targets PTPRS EGF EGFR MYC CCND1 SRC STAT3 PMC7655627__F2 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies TSC2 PIG59 TSC1 BRAF SLC7A6 MYC PIK3CA PTEN GLS PMC7655627__F1 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies TSC2 TSC1 PTEN CAD DEPTOR MTHFD2 RHEB PMC6584411__F7 Mechanism diagram MMP2 CDK2 MMP9 CCND1 CDK4 CDH2 CDK6 CCNE1 PMC7937231__F10 Bacterial invasion of epithelial cells pathway (KEGG ID: hsa05100) in the CoNS vs ARHG WASL HEL-S-28 ARHA CAV2 CLTC HEL114 CRK ARPC4 CBL PMC3407530__F5 A simplified model for p80HT targeting the IL-10-Stat3 signaling pathway to promote plasma cell expansion and tumor development CCND1 TYK2 JAK1 CCND2 STAT3 PMC8745127__F2 Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment MFN1 PINK1 MFN2 INF2 GRB7 FIS1 OPA1 BAX PMC9585222__F7 Improvement of gut-vascular barrier by terlipressin reduces bacterial translocation and remote organ injuries in gut-derived sepsis GSK3B PMC8073943__F5 EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer EPHA3 PTEN EZH2 PMC4287801__F1 Molecular pathogenesis and therapeutics of Marfan syndrome (MFS) MAP3K7 FBN1 SMAD4 TG TF PMC3160745__F1 PI-3K/Akt signaling pathway BAD GSK3B MDM2 PTEN MTOR IRS1 PMC11354507__F1 SARS-CoV-2 entry, mitochondrial damage sensing and innate immune dysregulation TBK1 NLRP3 PINK1 CGAS TLR9 TRAF3 IRF3 ACE2 ATG9A MAVS TMPRSS2 PMC11354507__F2 Inflammation triggered by macrophage after SARS-CoV-2 infection TBK1 CGAS TLR5 TLR9 STAT2 IRF9 TRAF3 TRAF6 IL6 MYD88 TLR1 STAT1 TLR7 TYK2 JAK1 ACE2 TMPRSS2 MAVS STAT3 PMC11809390__F8 Constitutive DRD4 activates TGF‐B receptors independent of ligands to promote CRC metastasis BMPR2 SNAI1 SET SMAD2 TGFBR1 TGFBR2 SMAD4 DRD4 SMAD1 DKFZp781O1323 SMAD9 PMC5779628__F11 Excitation–transcription coupling responsible for maladaptive metabolic and antioxidant remodeling in HF TH NRF1 NNT MCU BDNF PPARG RYR2 TFAM NR1C1 RXRA PMC6444160__F6 Networks of Ingenuity Canonical Pathways results of mRNA of APP/PS1 and SAMP8 mice brain tissues LYPD1 COBL PCDHA12 TH SYNE2 BOC RPP25 PTN RASD1 SHANK3 EMILIN2 CTNNA3 PENK DNMT3B E2F3 TACC2 JMJD1C FST HOXB4 RARA RARB opn LPL THBS1 CAV2 CENPA RELN PLK2 HOXB7 RPRM GLT8D2 CD44 FGF13 TNFRSF11B HOXB5 KCNA1 RET GABPB2 EPHX4 S100A8 TP73 CENPU KRT80 PRUNE2 EMX1 ZNF76 MYT1 HOXB6 PMC3242418__F1 HER 2: Biology, Detection, and Clinical Implications EGF HRG TGFA TF PMC3471161__F1 VEGF pathway and the site of action of the inhibitors VEGFC VEGFA VEGFB PMC3964016__F1 Cl− channels and proposed functions in vascular smooth muscle cells CLCA1 EEA1 RAC1 CFTR PMC6320922__F1 Drosophila Jak/STAT signaling components and the corresponding human homologs and their protein families IGF2BP1 BRWD3 EYA2 STAT2 CSK HEL-S-97n CEBPA IL6 STAT5B BCL6 CEBPD STAT1 BPTF EYA1 STAT4 PIAS1 SRC REST PHIP SOCS5 SOCS1 STAT3 PMC8163803__F6 Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes MBD5 FOXG1 CHAC2 PMC4381506__F2 Transcript abundance of genes related to central metabolic pathways under different conditions in K HEL-S-49 AIP CD2 SP1 TK1 PMC4838297__F6 Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells COX2 TRADD TRAF2 PMC3416387__F5 Proposed metabolic pathways for central carbon and nitrogen metabolism in Y88 during glucose growth, based on protein identifications (dark gray ovals) and the presence of their corresponding genes in the Y88 genome PTS HBD FH CIT TNLG7C NIFK MAL SDHB HEL-S-162eP PMC9332298__F2 PNPLA1-Mediated Acylceramide Biosynthesis and Autosomal Recessive Congenital Ichthyosis ABHD5 DGAT2 ELOVL1 ELOVL4 CERS3 ACSL1 TG KDSR CYP4F22 PMC2537575__F5 NFKB canonical signaling pathway from IPA EGF LTA NGF LCK RELA ZAP70 RELB PLCG2 TGFA TRAF2 TIRAP PMC7657020__F3 Predicted interaction map of SARS-CoV-2 proteins and top 20 host proteins associated with cytokine signaling pathway and Neutrophils degranulation EGF CYBA TMEM30A MAPK8 EGFR NRAS UBB GAA UBC CMTM6 SRC CCND1 UBR4 STOM ATP6V0C TNF HRAS CYBB C3AR1 SNAP23 ITGAM CD59 NFKB1 RELA ADAM10 VAMP8 STAT3 PMC3817742__F7 ABCB10 and heme synthesis pathway ALAS1 ALAS2 ABCB10 PMC4068075__F3 Consequences of EMT on innate signaling TRAF1 RELA TRAF3 IL6 CDK9 PMC7549355__F1 Hypoxia-inducible factor (HIF) and examples of long non-coding RNA (lncRNA) involvement VHL EZH2 PMC6413748__F3 Synthesis pathway of cardiolipin from lysophosphatidylcholine and lysophosphatidic acid PGP PTPMT1 HEL-S-5 PMC5023675__F1 TNF-Alpha-activated canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) signaling pathway TRADD TRAF2 PMC4957230__F4 Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand BAMBI SOCS3 DHX58 HIVEP3 TNIP3 POPDC2 CX3CL1 IRAK2 CCL2 CCL1 USP18 NLRP3 ISG15 OAS2 opn CXCL6 SERPINA1 CSF2 PSMB9 SELE CXCL11 ITGB3 CFB MAFF LRIG1 LIF CXCL10 TRIM25 TNLG7A HLA-F NINJ1 SDC4 PIM3 IL15RA TRAF3IP2 TNFAIP2 CSF1 IFIH1 IRAK3 PMC9241180__F7 circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer MTSS1 GSK3B PMC10378150__F1 STAT3 deficiency prevents GVHD in target organs while preserving GVL activity in lymphohematopoietic tissues MYC STAT3 PMC7550743__F3 Amino acid metabolism regulates PDAC progression ME1 GOT2 FOXO3A SLC7A11 CXCL5 ASNS GSK3B ARHA KCNN4 MTOR GABRP HSF1 PMC2815894__F2 Network of ABA-induced stomatal closure PC HEL-S-84 GC RAC1 PMC10447124__F8 Mapping of Rap1 signaling pathway in NI vs INVS NOTUM PORCN ARHA IVL HRAS CRK PS1TP5BP1 SRC NR1C2 GNAS AFDN LAT PMC7073900__F1 Key hallmarks of the ferroptotic pathway of cell death GPX4 FACL4 ALOX15 PMC8653577__F2 Maturing heart muscle cells: Mechanisms and transcriptomic insights ERBB4 HIF1A MTOR PMC2940871__F3 Metabolic reactions involving the PGM2 (adapted from ) XK PGM2 XDH RPE PMC7988757__F5 Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension TSC2 TSC1 FGF10 RHEB SPRY2 PMC8370908__F3 Alteration of protein expression and spliceosome pathway activity during Barrett’s carcinogenesis TH HNRNPR SRRT CTNNBL1 CRNKL1 DNAJC8 PUF60 DHX15 PRPF19 HNRNPD SYMPK CPSF1 MAL PMC7652990__F2 Network of pathways involved in respiration, ethylene biosynthesis, and signaling, and ROS production and signaling during the ripening process MTR MYC GLA PMC5023675__F5 Non-canonical NFKB signaling pathway RELB TRAF2 PMC9188076__F5 Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction PC PMC9037237__F5 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction CHUK BRAF ARHA PTEN TNF MTOR HRAS DEPTOR RHEB DVL1 IKBKB TSC1 IGF1 FNIP2 GRB2 SESN2 GRB10 SGK1 SKP2 PMC9037237__F6 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction CHUK TRADD PPP3CA ATF2 MYC ATF4 APP ECSIT ARAF APMAP FOS TNF HRAS HEL-S-102 MAP2K1 MAX HP NFKB1 JUND RAF1 DUSP2 SOS1 TRAF2 MEF2C CDC42 PMC10887079__F1 Nrf2 signaling pathway KEAP1 RBX1 PMC9289362__F1 Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells BAX PMC4606185__F1 Wnt/Beta-catenin signaling pathway in high glucose condition APC LRP5 LRP6 PMC3579516__F7 Alliance for Cellular Signaling Plasmid Collection DKFZp313C1916 ALK ADCK2 OBSCN MARK4 TEC FGFR4 ITK hCG_1641087 BMPR2 KDR MAST2 WEE1 TRIO ACTR2 ROCK2 MAPKAPK2 CSK PRKX FES SPEG NRK FER H1-1 MLKL HUNK CASK NRBP2 GSG2 RYK TLK2 PSKH2 RIPK2 SCYL2 LATS2 STK33 GRK7 CDK7 DMPK INSR RNASEL RNASE1 ATM FRK PKD1 LTK MASTL KIT PLK2 MOS PLK3 SNRK ULK4 PLK4 BLK DAPK2 GRK4 SRM PKN3 LYN SLK WNK2 DYRK2 ADRBK1 MYT1 PMC9037237__F4 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction CHUK BAD CSF3 MYC BCL2L1 PTEN POR PRKCA TLR4 G6PC3 PCK2 CD19 ABL2 FOXO3A CDC37 HRAS RHEB MLST8 TSC2 MTCP1 CYC1 GRB2 PPP2CA STK11 BCL2 MCL1 PMC11597624__F1 Secondary metabolites in invasive weeds, for the synthesis of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), methylerythritol phosphate (MEP), and mevalonate (MVA) pathways responsible MVD IPP MVP PMC6121366__F6 KEGG and BioCarta pathways of proteins encoded by genes related to cell cycle and ROS whose expression was altered in BS-24-1 cells after treatment with ethyl acetate extract of A E2F4 MYC SMAD4 PTEN CDK7 TSC2 CASP3 PERP ATM CDK2 MDM2 CASP9 CDK4 ATR RAD21 SMS PCNA SKP2 BAX PMC6881718__F6 Cellular context of TLR5 engagement by UPEC FliC in the bladder leading to early IL-10 induction TBK1 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR7 TLR4 CASP8 CD14 TLR5 CTSK IRF7 IRF3 RAC1 TLR1 MAP3K7IP1 TLR3 LBP CD40 CD80 FADD TIRAP PMC3185786__F1 Survival pathways controlled by Tax RELA PTEN RAF1 PMC4396490__F10 Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles P2RX7 IL1B TF PMC7590701__F6 Network analysis and hypothetical model construction RUNX1 LEFTY2 KLF4 CD44 JAM3 RHD FGFR2 PS1TP5BP1 BMP4 FLII STAT3 PMC8812184__F8 RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures BAD EGFR FGFR3 PTEN HRAS CDKN2A PLAT ERBB2 CDK2 MDM2 SRC BCL2 NKX3-1 TF GLS PMC7017262__F2 Molecular H CSK ERBB3 RND2 EGFR HBEGF RHO RAC1 ADAM17 VAV2 PMC6164133__F1 Intracellular signalling pathways of vitamin A RARA HEL111 RBP4 SRC FABP5 PMC7569467__F1 Schematic graph demonstrates the role of glial cells and the relevant signaling pathway IL10 NLRP3 IL16 TLR4 NPY KMO PMC3083931__F1 Canonical and noncanonical nuclear factorKB (NFKB) activation pathways RNF11 RELA RELB CD40 LTBR ITCH PMC9123888__F6 Possible mechanisms of the effect of melatonin in HDP cells GSK3B MTNR1A MTNR1B PMC9456295__F2 Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory EEF2 EIF4E MTOR PMC4374983__F2 Serum response factor pathway in myelopoiesis and myelodysplasia with 5q abnormality CD14 EGR1 TLR4 ARHA CTNNA1 PMC4374983__F1 Serum response factor pathway CACTIN ARHA PMC2666387__F7 Proposed Src involvement in HCEC wound healing ERBB2 EGFR SRC HBEGF PMC8750386__F8 Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts TLR4 ATM CDK2 SSB TRAF6 MYD88 RB1 HEL-S-128m PMC8234963__F6 Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NFKB Signaling Pathway and NLRP3 Inflammasome Activation NLRP3 COX2 TLR4 MYD88 TNF TIRAP PMC3632588__F6 Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta STAT1 JAK1 SOCS1 PMC8835057__F8 Cytokine Receptors—Regulators of Antimycobacterial Immune Response TYK2 JAK1 STAT3 PMC8835057__F9 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT1 TYK2 JAK1 STAT3 PMC8835057__F6 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT1 STAT4 TYK2 IL23R STAT3 PMC8835057__F7 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT1 JAK1 PMC7725871__F2 TLR4 signaling pathway: TLR4 is localized on the cell surface for ligand recognition, some of which are recognized after TLR4 interacting with MD2, even requiring CD14 and/or LBP involvement CD14 HMGB1 TLR4 LBP MYD88 MTOR PMC4011959__F3 The initial stages of vesicle elongation in macroautophagy ATG12 ATG3 ATG10 DKFZp686F0183 PMC6032341__F3 ATM-dependent DNA Damage Response KAT5 ATM RANBP9 PMC8674037__F6 Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice MAF ADIPOR1 KEAP1 RBX1 PMC4166552__F9 Model of cooperation of PLCB3 in the P.aeruginosa-dependent signaling in bronchial epithelial cells PLCB3 TLR5 MYD88 PMC6174755__F3 Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Wnt pathway ROCK2 MMP7 COX2 CLDN1 APC GSK3B CCND1 NRCAM ARHA RAC1 WIF1 ENC1 PMC5824910__F1 G-alpha signaling pathway in uveal melanoma AMOT RHO PTEN MTOR TRIO PMC2946515__F3 Mutant epidermal growth factor receptor, EGFRvIII, promotes cell survival and proliferation by preferential signaling through the phosphotidyinositol-3-kinase (PI3K) pathway EGF EGFR MTOR PMC2785881__F3 Sialic Acid Utilisation and Synthesis in the Neonatal Rat Revisited GNE CMAS SLC35A1 NAGK PGM3 NANS OGT SLC35A3 SLC17A5 NPL RENBP NANP PMC6487163__F1 Process and regulatory mechanism of autophagy ULK1 ATG12 MTOR DKFZp686F0183 PMC11487528__F2 COL10A1 regulates EMT, tumor cell proliferation and metastasis by phosphorylating Smad in conjunction with DDR2 and activating the TGFB signaling pathway MMP2 MMP9 CDH2 DDR2 COL10A1 SOX9 PMC11487528__F3 COL10A1 activates signaling pathways and regulates gene expression METTL3 CDH2 DDR2 COL10A1 PMC6488374__F3 Molecular mechanisms that regulate quiescence and activation of McSCs niche in telogen and anagen, respectively COL17A1 EDN1 NFIB DKK3 SMAD2 EDN2 LRP5 LRP6 HES1 PMC7059124__F1 Schematic illustration of the autophagic pathway ULK1 ATG12 ATG3 ULK2 UVRAG ATG10 MTOR DKFZp686F0183 PMC7182350__F1 Rac GTPase activity is regulated by synaptic activation through synaptic receptors that are known to be involved in memory formation such as NMDA, Trk, and Eph receptors TIAM1 ABI2 BDNF CYFIP1 EPHB2 EPHA4 PMC7059124__F4 Hepatotropic oncogenic viruses and their impact on autophagy regulation ULK1 ATG12 ATG3 SHB ULK2 UVRAG MTOR DKFZp686F0183 SIRT1 PMC2311419__F1 P. gingivalis accelerates gingival epithelial cell progression through the cell cycle WEE1 CCND1 PMC11487528__F4 COL10A1 in malignant tumors LEF1 METTL3 SMAD2 FAP VSNL1 TUG1 CDH2 DDR2 COL10A1 SOX9 PMC6585451__F2 Gut mycobiota in immunity and inflammatory disease IL17F MTOR CSF1 PMC8495217__F3 Different View for an Old Disease: NEDDylation and Other Ubiquitin-Like Post-Translational Modifications in Chronic Lymphocytic Leukemia NEDD8 TNF TRAF2 PMC9241412__F2 Regulatory role of Pin1 in neuronal death PIN1 BAX PMC9120690__F1 Targeting O-GlcNAcylation in ischemic stroke PGM3 OGA GNPNAT1 XBP1 PMC3918861__F2 Induction of apoptosis BAD TRADD FADD BAX PMC3928706__F1 Mechanism underlying GD T cell killing of tumours: GD T cell receptor (TCR) interacts with isopentenyl pyrophosphate (IPP) generated through the mevalonate pathway in tumours MICB MICA IPP PMC12230168__F7 Molecular mechanism of rosmarinic acid synergistically enhancing gefitinib efficacy in EGFR-mutant lung cancer by inhibiting cancer-stromal interactions and miR-21 signaling pathway FAP PMC8073623__F1 New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges LATS1 LATS2 PMC9469021__F10 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus CTSA IL1B IFNG PMC9469021__F11 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus BAD CASP12 CASP10 CDK6 CASP3 CDK2 CASP9 BCL2 CDK4 TNFRSF10A CASP8 FADD BAX PMC4661094__F1 RPE Necroptosis in Response to Oxidative Stress and in AMD TRADD BMF FADD PMC3118263__F4 Pathway analysis links the differentially expressed gene signatures of the MED29 transduced Hs 700T and MIAPaCa-2 cells to a cellular network involved in cell cycle, cancer, and genetic disorder AURKAIP1 HMMR FOXM1 PTPRK LGALS8 HJURP HCTP4 AURKA PTTG1 CDCA8 CENPA AURKB PMC1603666__F9 Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling TSC2 EGF TSC1 MTOR RHEB PMC11688305__F1 The structural comparison and similarities between CD4 and LAG-3 APC ADAM10 LAG3 ADAM17 PMC4661094__F2 RPE Necroptosis in Response to Oxidative Stress and in AMD TRADD RIPK3 TRAF2 MLKL PMC7098936__F1 Drugs in development for the treatment of achondroplasia FRS2 FGF2 GRB2 FGFR3 CNP PMC6880832__F7 Schematic illustration of miR-4666-3p and miR-329 are both low expressed in non-QCCSCs and synergistically regulate TGFB/Smad pathway SMAD2 TGFBR1 SMAD4 PMC6563192__F7 DEGs that are located in the neighborhood (putative cis-targets) of DELs and that are associated with Notch signaling pathway and stress granule formation HES5 NUMB EIF2A HES1 PMC3983496__F2 The proposed intracellular signaling pathways regulated by Cx43 hemichannels in bone cells BAD ASB1 SRC PTH PMC219483__F1 Biochemical pathways of TSH and folate metabolism in Leishmania HEL-S-64p DHFR FPGS PMC11855067__F3 Core genes of key signaling pathway map of tectoridin against ischemic stroke ME1 BAD CD37 PTEN MTOR IRS1 RHEB TSC2 BCR RAE1 MDM2 GRB2 EIF4B RBL2 CD19 PMC8024517__F1 Proposed mechanisms by which innate immune responses not only induce inflammation but also skew emerging adaptive immune responses towards a response that amplifies myeloid cell activation in mycobacterial IRIS or COVID-19 CXCL10 CCL2 IL1B CCL3 PMC5831775__F2 Simplified scheme of the cilia-mediated HH signal transduction pathway in vertebrates KIF7 GSK3B SMO PMC3464365__F1 Linking cellular metabolism with the circadian clock transcriptional complex NAMPT HDAC3 NCOR1 EZH2 SIRT1 PMC8991826__F9 TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway CCND1 CDH2 MTOR BAX PMC7278240__F3 Brain oxytocin: how puzzle stones from animal studies translate into psychiatry TRPV2 OXTR NPY5R EEF2 EGFR PMC4989114__F10 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate BCO1 RDH10 PMC9694413__F3 Biodegradation and Metabolic Pathway of the Neonicotinoid Insecticide Thiamethoxam by Labrys portucalensis F11 TMX4 TMX3 TMX2 PMC7116063__F7 Signal integration in the (m)TORC1 growth pathway NPC1 FLCN SLC38A9 CASTOR1 RILP SESN2 RHEB PMC8714756__F5 Adaptation Strategies to Improve the Resistance of Oilseed Crops to Heat Stress Under a Changing Climate: An Overview SNRK ABI3 PMC6834478__F2 Mouse models used to study the PI3K/AKT/mTOR axis in PCa PML TTI1 TSC1 PTEN DEPTOR RHEB PMC7236745__F3 NF-kB/E2F/Rb and p53/p21 pathways by proteasome.NF-kB/E2F/Rb pathway: under unstimulated conditions, NF-kB is kept inactive in the cytosol by IkB inhibitor CDK2 APC CCNB1 MDM2 CDC2 PCNA CCNO PMC7116063__F1 Signal integration in the (m)TORC1 growth pathway FLCN CASTOR1 SESN2 RHEB PMC6614068__F6 Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy HEL-S-15 PMC5301350__F7 Differentially expressed genes (DEGs) in photosynthesis pathway in different combinations PC SP4 CYB SP3 PMC6636296__F1 metabolic pathways in cancer cells MTOR PMC6636296__F2 Network of Wnt signaling regulates tumor metabolism reprogramming TSC2 TSC1 APC MYC MTOR PMC6142822__F3 Gut-brain communicates with the brain mainly via three pathways of the microbiota–gut–brain axis IL16 BDNF TGFA PMC6535379__F1 Signaling pathways involved on induction of endoplasmic reticulum (ER) stress ATF4 EIF2A XBP1 PMC4162005__F1 Model for regulation of expression/activity of multiple P450s by AKR1D1 CYP27A1 CYP8B1 CYP7B1 HSD3B7 PMC7573490__F4 Interaction of Leptospira interrogans with the innate immune system NLRP3 TLR5 TLR4 NOD1 MYD88 TLR1 IL1B NOD2 PMC4014576__F6 Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling CASP3 PTEN CASP8 PMC8931761__F1 Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms SMAD2 ZEB2 GSK3B SMAD4 PTH CDH2 MTOR PMC7234920__F2 The compartmentalization and interplay between the extracellular and intracellular pathways for (acyl-)CoA degradation and intracellular CoA synthesis VNN2 ACOT8 NUDT7 NUDT19 PPCDC PPAN SLC25A17 PANK2 PANK1 PPCS PANK4 NUDT8 PANK3 HEL20 COASY VNN1 PMC8377541__F8 CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/Beta-Catenin Signaling Pathway in Glioma LEF1 APC GSK3B LRP5 LRP6 FRAT1 CR2 AXIN2 CR1 TCF4 PMC5445305__F7 Characterization of central metabolic model in developing L ENO3 PDC INVS PC HEL-S-304 GIP LPA RPE MAL HEL-S-162eP PMC6936734__F1 Schematic representation of sphingosine-1-phosphate (S1P) pathway SPHK1 SPNS2 SPHK2 SMS PMC12072856__F1 Bacteria antagonize p53 protein by mechanisms of its destabilization or by reducing expression of its mRNA TLR4 EGFR MDM2 PMC4753639__F8 Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation NOX3 EGFR WAS MSRA PMC6629768__F1 Some examples of lncRNA mechanisms that unfold in the cytoplasmic compartment ULK1 DRAM2 PMC2952341__F1 Alteration of Notch signaling in skeletal development and disease LEF1 RBPJ PSEN2 PSEN1 DLL4 JAG2 DLK2 DLL3 HES1 PMC9370431__F5 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action LPL PMC9312335__F4 High-Temperature Stress Effect on the Red Cusk-Eel (Geypterus chilensis) Liver: Transcriptional Modulation and Oxidative Stress Damage ELF2 CASP12 ATF4 SVIP BCL2 PMC11995091__F2 Sketch represents the impact of nano-encapsulated tea polyphenols impact poultry health GPX4 TLR4 GPX1 MYD88 PMC9370431__F4 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action VCAM1 IL1B PMC10672284__F1 Multifaceted functions of (AMPs): (A) Depiction of the signaling pathway involved in Gram-negative bacteria-induced infection caused by lipopolysaccharides (LPS) LBP IRAK4 MYD88 TNF TIRAP PMC10670481__F6 Analysis of KEGG pathway and interactive enrichment networks PRMT1 PDE3B HEL-S-30 F2 GIP CRTC2 CIT PYGL PMC2856448__F1 Opposing influences on Foxo cellular localization and transcriptional activity PRMT1 OGT PTEN SIRT1 PMC11674267__F1 Mechanistic pathway of methuosis-induced vacuolization NGF PIKFYVE RAC1 PMC11674267__F3 Schematic summary of alkaliptosis pathway induced by JTC801, a pH-dependent form of cell death HMGB1 MITA AGER ATP6V0D1 CA9 STAT3 PMC5872768__F1 Possible routes of lipid oversupply-induced insulin resistances associated with mitochondrial and endoplasmic reticulum (ER) stress MFN1 MFN2 GPR75 IRS1 PMC11674267__F4 How SNG induces oxeiptosis in colorectal cancer cells based on [20] AIFM1 PGAM5 PMC7465688__F1 Postulated signaling pathways affecting endothelial progenitor cells (EPCs) EGF CXCR4 DKK1 PMC5345629__F5 Validation and interaction networks of the differentially expressed miRNAs PMC7156293__F3 The MyD88‐dependent and MyD88‐independent pathways mediated by TLR4 ligation to induce NF‐KB activation and cytokine gene expression TLR4 IRAK1 IRAK2 PTGS2 TRAF6 IRAK4 MYD88 TNF MAL PMC8892735__F4 Long and short non-coding RNAs modulating EZH2 signaling in cancer MMP14 BRMS1 CXCR4 YY1 HNF1A EZH2 E2F3 SOX4 HK2 PMC2810075__F6 CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts CXCR1 PTEN FADD PMC3698571__F2 Advances in targeting cell surface signalling molecules for immune modulation CD27 APC BTLA CD40 LAG3 PMC11844401__F1 Four-step protopathway (highlighted in lilac) restores growth of ΔpdxB E PDX1 HEL-S-1a NR1A2 PNP PMC6562762__F8 Hypothetical model of Se homeostasis in brain GPX4 SELENOP SELENOW HEL-S-134P SELENOF PMC7254712__F4 Graph of the ECM–receptor interaction pathway (17) NPNT VTN CD44 VWF CHAD CD36 PMC8892735__F1 Long and short non-coding RNAs modulating EZH2 signaling in cancer EZH2 SUZ12 EED PMC3368236__F5 Sema3E-PlexD1 signaling regulates pathway-specific synapse formation in the striatum HEL70 SEMA3E DRD1 PMC8305917__F3 The Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom IQGAP1 ARHA RAC1 PMC3135645__F1 Coordinated regulation of p53, target of rapamycin (TOR), and insulin/insulin-like growth factor 1 (IGF-1) pathways IGF1 MDM2 PTEN RHEB PMC10304713__F2 SARS-CoV-2 employs different mechanisms to activate the host’s innate immune system IRAK1 IRF9 TRAF6 IRF3 IRAK4 MYD88 REL TRIM25 MAVS PMC3031055__F3 TFM-C-induced alteration to IL-12p40 chaperone interactions DERL1 PDIA2 PMC2670002__F7 Pathway in colorectal cancer (CRC) progression from normal colon to late-stage cancer EPHB1 EPHA1 EPHA2 EPHB4 EPHB2 PMC11012558__F6 RTK pathways IGF1R PDGFRA EGFR CCND1 STAT3 PMC3798952__F1 EpCAM and WNT signalling pathways EGF EPCAM APC FHL2 ADAM17 PMC11012558__F3 Calcium and Neural Stem Cell Proliferation TRPC7 TRPC4 TRPC1 FGFR1 TRPC6 TRPC3 ORAI1 STIM1 PMC10970237__F5 Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways TSC2 TSC1 EIF4E EIF4B PMC11012558__F4 TRPVs and neural stem cell proliferation EGF TRPV4 CS IGF1 TRPV2 TRPV3 PMC11003748__F2 Clastokines produced by osteoclasts and osteoclast precursors and interaction with their receptors on cells from the osteoblast lineage CTSK RUNX2 NFATC1 LIF EFNB2 LRP5 ROBO2 RHO SLIT3 RAC1 SPNS2 COL1A1 BGLAP EPHB4 CTHRC1 WNT3A ROBO1 ROR2 SPHK1 CDH2 SP7 STAT3 PMC8620617__F4 Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye LRAT HEL111 RBP4 PMC7140477__F1 Major carbohydrate metabolic pathways PDC GLS PMC11003748__F1 Matrix-derived coupling factors CXCL16 BMP1 IGF1 MTOR WNT10B PMC3564224__F2 Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 SIRPA CD47 SRC BCL2 BNIP3 PMC7959691__F4 PTP regulation of adhesion complexes and related pathways PTPN21 GRB2 SRC PTPN13 LATS1 PTPN6 LATS2 PTPRF TRIO PMC5597736__F1 Interactions between DNA tumour viruses and the DNA damage response RNF168 RNF8 ATM ATRIP ATR H2AX STAT3 PMC9628250__F2 The Wnt signalling pathway in the energy metabolism of bone remodelling CD36 GLS PMC9628250__F3 The Wnt signalling pathway in the energy metabolism of bone remodelling APC SOST GSK3B LRP5 TCF7L2 PMC3389016__F3 Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers MT3 HPCAL1 PDK2 NEF3 DLD RPL18 PS1TP5BP1 KSR2 RPS18 MAP2K1 SLC2A4 FARSB TRIB1 ARC HEL-S-112 SP1 PDHX CLIC4 DLAT RPS12 STAT3 PMC9265870__F1 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications FOXC1 MAML1 NUMB SOX2 APC PTCH1 RELA GLI3 JAG2 RELB SMO LBH PMC9265870__F2 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications HEL-S-62p IL7 HGF LEPR CCL2 DKFZp686F0183 PMC5516940__F5 Downregulation of several proteins in the oxidative phosphorylation pathway identified in the global proteomic data for LNCaP-95 androgen resistant prostate cancer cells SDHC NDUFA7 CYB COX2 ND6 COX3 COX17 ND3 ND2 NDUFB10 NDUFA11 ND4 SDHD SDHA SDHB PMC9628250__F1 The Wnt signalling pathway in the energy metabolism of bone remodelling MSC WNT10B WNT7B PMC10037657__F1 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer MTOR NR1C1 FADD PMC10838672__F1 VEGF protein family and receptor signaling pathway PIGF VEGFC VEGFA VEGFB PMC12181099__F1 Interactive effects of MSC and AML cells on each other CXCL1 METTL3 MSC CD44 CD80 CTLA4 CXCL12 CCND2 BAX HOXB6 PMC10037657__F2 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer PAK1 LIMK1 TWIST1 MAPK1 CDC42 PMC10838672__F2 RTKs and its related downstream signaling pathways and their targeted therapies for hepatocellular carcinoma EGF HGF EGFR PTEN MTOR PMC10037657__F3 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer EZH2 MTOR PMC10838672__F3 PI3K/AKT/mTOR signaling pathway and targeted inhibitors TSC2 RET BAD TSC1 ERBB2 EGFR GSK3B CCND1 SRPK2 PTEN FOXO1 PMC4385526__F2 Innate immune evasion of hepatitis C virus infection IFNL3 STAT2 IRF9 IRF3 TYK2 IFNAR2 IFNAR1 TLR3 MAVS IFNLR1 PMC10838672__F4 Wnt on and Wnt off state of Wnt/B‐catenin signaling pathway and therapeutic strategies based on them APC GSK3B LRP5 LRP6 PMC10838672__F5 JAK/STAT signaling and targeted inhibitors STAT1 STAT2 STAT4 TYK2 JAK3 JAK1 STAT5B STAT3 PMC10838672__F6 Smo‐driven canonical Hh signaling pathway and targeted inhibitors KIF7 SUFU PTCH1 GLI3 SMO PMC8079635__F1 Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes AREG LIF MMP9 IL33 FURIN OSM CCL3 PMC9276080__F1 MicroRNAs and their signaling pathway in mycosis fungoides IL21R STAT4 JAK3 STAT3 PMC9276080__F2 MicroRNAs and their signaling pathway in mycosis fungoides BMI1 FCRL3 STAT3 BRD4 PMC8377203__F2 Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids ATM TOPBP1 ATRIP ATR H2AX BRCA1 PAXX PMC8253276__F6 Upregulation of Nogo‐B by hypoxia inducible factor‐1 and activator protein‐1 in hepatocellular carcinoma SRC CDC42 PMC9626809__F1 Sulfur compounds in chronic obstructive pulmonary disease PMC7720622__F2 Estrogen signaling pathway with altered proteins in pterygium tear proteome in highlight PGR TFF1 EGFR GRB2 BCL2 EBAG9 HBEGF KRT13 TGFA HEL-S-130P TF PMC8819303__F2 Aberrant RNA splicing and therapeutic opportunities in cancers U2AF1 PHF5A U2AF2 PMC10159521__F9 miR-613 suppresses renal cell carcinoma proliferation, invasion and migration by regulating the AXL/AKT pathway AXL PMC11992794__F5 Analyze the DEGs within metabolic pathways UGDH GALK2 HEL-S-162eP PMC6953055__F1 HBx-dysregulated miRNA in the P13K/MAPK liver cancer pathway EDN1 HGF PTEN MTOR PMC5668305__F7 The pain related mechanisms of Notch1 and TLR4 signaling pathway TLR4 NOTCH1 HES1 PMC6953055__F2 Dysregulated miRNA in the WNT/Beta-catenin liver cancer pathway APC TRPS1 PMC6953055__F3 Dysregulated miRNA in the TP53 liver cancer pathway CASP3 CASP9 CDK4 CASP8 CDK6 BAX PMC7493703__F1 Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib CCR5 VEGFA KLF13 CCL3 PMC6953055__F4 Dysregulated miRNAs in the JAK/STAT liver cancer pathway SOCS3 EBP MYC IL6ST MTOR PMC11932658__F1 n-6 and n-3 HUFA biosynthetic pathway FADS2 ELOVL5 FADS1 MYRF ELOVL2 PMC7729760__F1 Autophagy—A Hidden but Important Actor on Oral Cancer Scene TSC2 ULK1 TSC1 ATG101 MTOR PMC3124877__F1 Pathway of alcoholic injury resulting in the direct production of oxidative stress and the LPS-TLR pathway that culminates in production of cytokines and other inflammatory processes that result in hepatitis of the liver TLR4 MYD88 CYP2E1 PMC9130956__F1 Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells EGF ECD FAT1 PMC4238866__F3 Glucose activation of the cAMP-PKA pathway RGS2 PDE12 PMC8718071__F8 Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome CYP27A1 CYP7B1 FGFR4 CA4 BAAT PMC7024330__F1 AR mediated gene transcription in different subtypes of breast cancer FOXA1 TF PMC3579397__F1 Sulfide production HEL-S-182mP SUOX PMC4238866__F1 The Snf1 protein kinase as a central player in the main glucose repression pathway PCK1 FBP1 PMC7024330__F2 AR signaling pathway and targeted therapeutic strategies against AR HSD3B1 SRC CYP17A1 TF PMC11050151__F2 Representative scheme of the 15 genes shared by the selected pathways using pathway enrichment analysis PTPRC NFATC2 FOS PTGS2 PIK3R2 PMC7885480__F1 Developmental signaling that govern CSCs and therapy resistance YAP1 APC KIF3A TEAD4 LATS1 LATS2 TEAD2 NF1 TEAD3 SUFU NF2 PTCH1 GLI3 SHH SMO PMC11050151__F3 Gene association networks that result from entering the list of eight genes—PIK3CG, PTGS2, FOS, PTPRC, VAV1, ITPR3, NFATC2, and PIK3R2—as input into the GeneMANIA software PIK3CD PPP3CA EGFR TEC TRPM5 FOSL2 PTGS1 PAG1 FOXP3 SEMA4D ATF4 CD3G JUN CD3E CD3D KIT PTGIS PRKCQ FOS PTGS2 VAV1 IGFBP7 RAC1 CBL PIK3R5 PTPRC NFATC2 PIK3CA JUND KDM6B PIK3R2 PMC3469610__F6 Schematic diagram of proposed molecular mechanism of p27 downregulation in Fen-induced cell growth in fibroids IGF1R IGF1 CDK2 PMC5392045__F1 Schematic of the stimulator of interferon genes (STING)–dependent innate immune response pathway TBK1 CGAS IRF3 PMC8002044__F4 Potential network of signaling pathways contributing to the chicken lipid metabolism CH25H SCD CIDEC LPL DHCR24 MSMO1 CD36 PMC5133582__F7 Metabolic pathways in hepatocellular carcinoma SLA SCIN DAP ACD PMC8002044__F2 Adipogenesis and fat deposition and their regulation at the transcriptional and post-transcriptional level in the chicken adipocyte LPL DHCR24 KLF2 TG HEL-S-104 GATA2 PMC7500922__F4 Revisiting the PD-1 pathway JAK1 IFNAR1 STAT3 PMC12042674__F2 Signaling pathways regulating melanin synthesis TYRP1 MC1R PMC8873532__F1 Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology ATF4 EIF2A YME1L1 SSBP1 PMC7654982__F3 Therapeutic Options to Block the Activation of Hedgehog Signaling Pathway DHH IHH SUFU PTCH1 SHH SMO PMC7920173__F1 Autoimmunity in Acute Poststreptococcal GN: A Neglected Aspect of the Disease HEL-S-62p C9 C7 C6 PMC7654982__F1 Hedgehog Pathway in Female Cancers SUFU PTCH1 SMO PMC7654982__F2 Abnormal Hedgehog Signaling Pathway Leads to Female Cancers DHH IHH SUFU PTCH1 SHH SMO PMC5006394__F2 Metabolism on Foxp3 expression and the generation of Treg cells FOXO3A PTEN EZH2 MTOR SIRT1 FOXO1 FOXP3 PMC6307204__F5 NFKB signalling pathway is involved in endogenous DcR3 expression in HUVECs stimulated by LPS, LTA and zymosan LTA TLR4 IRAK2 TRAF6 IRAK4 MYD88 PMC8843787__F1 Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions COX2 COX1 TBX2 PMC4673016__F1 Transcriptional and chromatin regulation during fasting – The genomic era KLF15 TFEB EBP NR1C1 PMC8009749__F1 Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance KLF4 PTEN COXFA4 CERK IRS1 SOCS1 PMC8063120__F4 Long non-coding RNA (lncRNAs) and microRNAs (miRNAs) involved in osteogenic pathways in Bone Marrow Mesenchymal Stem Cells (BMSCs) RUNX2 SMAD2 APC SMURF2 SMAD6 SMURF1 SMAD1 PMC7461616__F1 Targeting lipid metabolism of myeloid cells in cancer immunotherapy TLR8 CCR2 TLR7 TLR9 CD40 CTLA4 PMC8055485__F1 Signaling pathways behind the role of CRP in cancer-induced muscle wasting IGF1R IGF1 FOXO3A RELA CRP EIF4E RPS6 REL MTOR IRS1 STAT3 PMC7561410__F2 Signaling pathways in the epididymitis induced by UEPC TLR5 TLR4 MYD88 TNF PMC3692518__F4 miRNA Signature of Mouse Helper T Cell Hyper-Proliferation PAK1 PHLPP2 CSK LCK GRB2 SPRY1 HRAS LAT SPRY2 PMC8960951__F1 Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo IL10 CXCR3 CXCL10 APC CXCL9 IL1B FOXP3 PMC4016161__F1 The succinate dehydrogenase complex (SDH), as a member of the tricarboxylic acid cycle (TCA), catalyzes the oxidation of succinate to fumarate SDHC FES SDHD SDHA SDHB PMC12114673__F9 Schematic diagram illustrating the mechanism of CCNB1 in melanoma cells resisting NK cell-mediated cytotoxicity MICB SMAD2 CCNB1 SMAD4 MICA CDC2 CD69 IFNG STAT3 PMC3482366__F1 Summary of folate metabolic pathway MTR MTRR DNMT3B PMC7601352__F2 Screening of key genes related to the prognosis of mouse sepsis PML NFE2 NCK2 OTUD7B DKFZp781B1423 TPM3 ITGA4 OPTN GATA1 STAT1 ITK EPN1 RPS27A KSR1 TGFB1I1 CNN2 PREX1 YWHAG IFNGR1 ACTN4 SPATA13 JUN ZFPM1 PARVB ITGA2B FOS CTNNA1 FERMT3 UBE2E3 tal-1 USP48 PKN1 IKBKB PTPRC SH2D2A SPI1 ZYX LCK ZAP70 DOCK2 TGFB1 ACTG1 PMC8350018__AF1 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway IGF1 CDKN1A TWIST1 SSB PMC12042419__F4 Schematic illustration of NOTCH3 signaling pathway involvement in the pathogenesis of CADASIL MAML1 RBPJ ARHA ADAM10 RHO NOTCH3 PMC3427155__F2 Analysis of Differential miRNA Expression in the Duodenum of Escherichia coli F18-Sensitive and -Resistant Weaned Piglets PDE4D PPP3CA EGFR VPS4B SMAD4 CREB1 ITGA4 LPAR1 CNR1 PLXNC1 SMC1A DCN SEMA4D PDE10A PPARGC1A ACVR2A AXIN2 XB PTPRM PRKAB2 RBL2 F11R FGF7 ABL2 SORT1 GDF6 CDC14B PDGFRA NR3C1 GNA13 CEBPA STAG2 CBL EDNRB NRP1 CTSC PPP2CA PIK3CA ATP2A2 CXCL12 LAMC1 EGLN2 ACTG1 IGF2R PDE7B PMC11640101__F4 Involvement of the ARF6-AMAP1 pathway and Arid5a in cancer progression and immune evasion IDO1 CCL2 HIF1A ARF6 EPB41L5 ARID5A HEL-S-133P MVP HK2 RAB11B PMC9485629__F1 Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression EGF EGFR BMP7 TGFBI PMC3351290__F10 TRPC1 channel is a major regulator of EGFR signaling EGF TRPC1 EGFR CCND1 CCND3 STIM1 PMC12038022__F2 Molecular mechanisms of ferroptosis and disulfidptosis GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 LRPPRC TFRC GYS1 POR RPN1 NDUFA2 NCKAP1 SLC3A2 NUBPL OXSM PMC3748092__F8 Cell Surface Glycan Alterations in Epithelial Mesenchymal Transition Process of Huh7 Hepatocellular Carcinoma Cell FUT8 GAL FUCA1 B3GALT5 PMC11640101__F1 Metabolic reprogramming in cancer ACLY HEL-S-133P MVP HMGCR HK2 FASN PMC10473115__F1 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease DAP SYK PMC10473115__F2 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease PLCG1 DAP SYK PMC10473115__F3 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease PLCG2 APOE PMC6468748__F1 Moonlighting functions of the endothelial protein C receptor (EPCR) PC PLG APC PMC9047859__F2 Functions of Stress-Induced Lipid Droplets in the Nervous System APOD APOE FASN PMC3489622__F2 Signaling networks induced in the spleen at 1 day post infection in wild-type mice (A) and STAT1 KO mice (B) PRKCZ STAT2 BAG3 IRF7 IRF9 IFITM2 VEGFA IRF3 IFNAR2 MX1 ADAR GBP1 OAS2 PRLR GBP2 IRF-1 ARNT2 PTTG1 PSME2 PMC7705468__F1 Mechanisms involved in the tenocytes during the process of diabetic tendinopathy EGR1 EBP HIF1A FOXO1 SCX SOX9 PMC7705468__F2 Mechanisms involved in the tendon stem/progenitor cells during the process of diabetic tendinopathy IGF1 RUNX2 BMP2 FPR1 ALOX15 MTOR TNMD SCX SOX9 PMC10473115__F4 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease DAP SYK PLCG2 PMC3382911__F1 Colon cancer cells produce immunoregulatory glucocorticoids EGF GC TNF PMC4178135__F3 Standardized pathway diagram calculated with a structural equation model of antepartal hormones in pluriparous dairy cows CFI PMC3202514__F1 Maturational changes in fatty acid and carbohydrate metabolism gene expression HEL-S-162eP PMC5086085__F5 Ecdysone receptor B1 (EcR‐B1) signaling to trigger pruning in MB G and da neurons VCP HDC SOX14 PMC6966863__F7 Mechanism for ABC transporters regulated by the level of PI3K 110A or 110B subunit TSC2 BAD PDK2 MTOR PMC8443474__F1 Aryl hydrocarbon receptor in liver inflammation AIP AHRR AHR CYP1A2 PMC8066875__F8 NFKB pathway and NLRP3 inflammasome activation and role of some microRNAs NLRP3 IGF1 IRAK1 IGF2 TRAF6 MTOR IRS1 IL1B AANAT AMT GSDMD PMC6722943__F9 Differentially expressed genes associated with the p53 signaling pathway TSC2 BAD PERP ATM CDK2 HEL-S-11 MYC MDM2 CASP9 PTEN PIGA ATR PMC7896869__F7 Involvement of SAB in enhancing proliferation and attenuating oxidative stress and apoptosis through activation of the JAK2/STAT3 signaling pathway STAT3 BAX PMC6659998__F3 FA/TAG metabolism in hepatocytes LIPC SLC25A20 DGAT2 PLIN1 ACACA ADFP HEL-S-104 DGAT1 APOB CPT1A CIDEC ACADVL ACACB ACSL1 ACLY CYP4A11 CIDEA ACADM FABP1 FASN CD36 PMC11603636__F7 Schematic mechanisms concerning the IRE1Alpha-XBP1 axis in LPS-induced acute lung injury NLRP3 TXNIP XBP1 PMC8165189__F1 Hippo Signaling Pathway in Pancreas Development PDX1 PTF1A LATS1 CPA1 SOX9 PMC7981372__F5 Exploring the role of Azadirachta indica (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach MMP9 BCL2 PCNA BAX PMC4219592__F1 Interactions between alcohol-induced mechanisms leading to hepatic carcinogenesis TLR4 CYP2E1 PMC11759193__F7 Mechanistic overview scheme of the effects of aircraft noise on endothelial function KEAP1 CRH CD68 PMC5520851__F1 mTORC1 controls cell growth and is regulated by the lncRNA-encoded polypeptide SPAR TSC2 ULK1 TSC1 PTEN EIF4E OTP IRS1 RHEB PMC6711114__F1 The main enzyme pathways involved in mitochondrial pyrimidine dNTPs metabolism CDA DCTD TK1 PMC6596841__F1 Gpr17 signaling pathway following lysolecithin insult GPR17 XAF1 OLIG2 PMC4831565__F4 GAPDH nitrosylation pathway mediates cocaine effects SIAH1 SUV39H1 HEL-S-162eP PMC9130470__F3 NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects GRB2 PTEN PMC5177915__F8 Citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway TLR4 ATF3 TF HEL-S-29 PMC8165189__F2 Hippo Signaling Pathway in Pancreas Development NFIB LATS1 LATS2 ADM PMC3984774__F4 RB/E2F pathway MAX MYC CDK4 SKP2 CCNE1 PMC8123608__F3 Autoinflammatory Features in Gouty Arthritis PGGT1B NLRP3 CD14 TLR4 INSIG1 ANGPTL2 APOC3 IL23R PPARGC1B SOCS1 CNTN5 PMC7554785__F3 Reduced TCF1 expression promoting a differentiation bias of activated aged T cells toward terminal effector cells LEF1 RUNX3 IL2RA MTOR BCL6 PMC3889649__F5 GLI1 target genes converge on a regulatory pathway that suggests roles in cell proliferation, survival and genomic stability TAF1 E2F4 PRPSAP1 NPM1 MYC CREB1 PRNP FYN HNF4A PDE4B MAX FOXA1 GRB2 YY1 RGS16 NTRK2 PMC6306051__F7 Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway NPM1 SKP2 PMC8159873__F3 Cellular pathways involved in trained immunity NLRP3 IGF1R APC TRAF6 CD40 MTOR CD36 PMC125566__F1A Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 APC PMC3413017__F1 Apoptosis and necrosis ATM MDM2 FADD BAX PMC5645527__F1 WNT signaling pathway activation APC GSK3B LRP5 CD44 LRP6 SOX9 PMC8851273__F9 Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling STAT3 PMC5948853__F8 A schematic of the model of crosstalk between STAT1 and TGFB signaling pathways SMAD4 JAK1 PMC9093150__F10 Working hypothesis of the role of the prostanoid pathway in angiogenesis inhibitor-induced hypertension and renal injury COX1 TET1 PMC3360095__F1 P2X4R-p38 MAPK is a core signaling pathway through which spinal microglia and peripheral macrophages contribute to neuropathic pain and inflammatory pain COX1 CCL21 BDNF PMC6147237__F1 A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity BTK ATF2 GSK3B ADRBK1 PMC7047255__F7 Pathway interaction schematic constructed to demonstrate overlap of gene expression data with critical osteogenic pathways RUNX2 GSK3B BGLAP BMPR2 PTCH1 opn GLI3 MSC SMO MSX2 SP7 SMAD1 DKFZp781O1323 PMC8847686__F10 Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder TRADD MAP3K7IP1 TRAF2 PMC6351482__F4 Mutation enrichment of Nectin adhesion pathway RAPGEF1 ITGB3 CLDN1 TLN1 CTNNA1 RAC1 PIP5K1C CRK RAP1A IQGAP1 SRC PIK3CA FARP2 ITGAV PTPRM F11R VAV2 CDC42 PMC6095456__F1 Regulation of innate immune cell function by mTOR TSC2 RICTOR RAB8A TSC1 PTEN MTOR SGK1 FOXO1 RHEB PDPK1 HK2 AKT3 PMC10892755__F1 Cholesterol and isoprenoid synthesis pathway illustrating how statins inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase ARHA RAC1 CDC42 PMC4568555__F1 Key transduction molecules of ErbB signaling pathway known to regulate cardiomyocyte viability and function BAD GRB2 MTOR BAX PMC8182305__F2 Aquaporins in insulin resistance and diabetes: More than channels! AQP11 AQP3 AQP7 INS AQP9 PMC5715262__F3 Molecular pathways around CIC in cancer ATXN1L CIC CCND1 ATXN10 CCND2 DUX4 PMC4698395__F5 Mechanisms of stretch-induced reactive oxygen species (ROS) production and Ca2+ influx in dystrophic muscle CAV3 RYR1 SRC RAC1 PMC7896225__F1 Proposed neuroprotective role of Withaferin A (WA) in the modulation of pathways implicated in neurological abnormalities and dysfunctions.Parkinson’s disease (PD): WA is a known inhibitor of the Cdc37/Hsp90 complex LRRK2 HEL-S-44 CDC37 PMC5392045__F2 Interplay between autophagy, apoptosis, and the stimulator of interferon genes (STING) pathway TBK1 CGAS IRF3 PMC7144958__F1 XPF–ERCC1: Linchpin of DNA crosslink repair FAN1 SLX4 ERCC1 PMC4417466__F5 RPPA analysis in HeyA8-MDR treated with ZA BAD GRB14 YAP1 EGFR MYC RB1 EIF4EBP1 CRK GRB7 MMP2 ERBB2 RELA GRB2 APP SRC UNK RAD51 MSH2 SP7 PXN STAT3 BAX PMC3376380__F1 mTOR signaling and its regulation by DGKs TSC2 RICTOR TSC1 MTOR RHEB PMC3841787__F5 Proposed signaling pathway model for VEGF-A signaling in hypoxia-stressed BM-EPCs compiled from the proteomic and gene expression analysis is highlighted here PIGF UNC13C CASR VEGFA RHO NOS2 PMC4446705__F1 The IL-4 and IL-13 receptor signaling pathways IL13RA2 IL13RA1 GRB2 PIAS1 TYK2 JAK3 JAK1 ARG1 IRS1 SOCS1 STAT3 PMC4687899__F2 Pancreatic Cancer Metabolism - Breaking it down to build it back up ME1 GOT2 RPIA RPE HEL-S-133P GLUD1 HEL-S-32 GFPT1 HK2 GLS PMC6322405__F1 Hippo signaling network and its biological functions OGT SRC SLMAP PMC5587470__F7 Diagram of muscle‐growth signaling pathway and differentially expressed genes, thus summarizing the effect of thermal gradient on muscle growth IGF1R IGF1 IGF2 MTOR PMC1180390__F5 Signaling pathways implicating p120-RasGAP RAP1A KRIT1 GRB2 SHE SOS1 PMC9200993__F1 Treg Cell Metabolism and Function in Non-Lymphoid Tissues STAT4 IL33 GCK IRF4 TFAM GATA3 BATF PMC2883511__F1 Signaling pathways and targets for LAM RHO EIF4E MTOR RHEB PMC6816394__F5 Role of tPA in the proliferative signaling and Wnt/Beta-catenin signaling GSK3B CCND1 PMC7015009__F1 Hic-5-mediated signaling pathways for tumor progression MMP9 SRC ARHA PMC6637639__F1 Interaction network of proteins underexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 82) ALB SERPINA3 CFI TSG101 HEL-S-78p A2M GC C7 SERPING1 EN1 FGA AKAP12 KRT73 HRG CES1 ENPP4 PLG DIABLO GFPT1 PTX3 HSPG2 VTN HEL-S-273 HBB APOH Nucb2 CP TF HEL-S-62p C4B_2 CLEC3B A1BG ANXA4 AP1B1 COPA AMBP CLU ITIH2 SERPINC1 HBA2 F2 CFH SERPIND1 IGLL5 KNG1 APOA2 MGAM CFB FTH1 GUGU HPR ALPL HEL111 GJA1 C4BPA S100A13 SERPINF2 TGFBI PMC6443908__F7 APR signaling pathway is associated with ozone exposure and bacterial infection TCF3 HAMP AHSG APOH AMBP TCF4 PMC7767264__F4 Representation of genes/pathways/transcription factors identified from host–pathogen interaction during aflatoxin production MYB ERF PMC6637639__F2 Interaction network of proteins overexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 116) MMP19 TBCD GNA14 PUF60 CHD4 BCCIP MTHFD2 BTF3 RPL31 SCD ATXN10 CAPZA2 SFRP4 SET DPYSL3 PSAP NUP210 DDB1 RPS10 MVD CRELD2 SETD7 EIF6 KPNA2 HSPBP1 DHRS9 CMBL ACACA EGFR UMPS PTK7 PFKM FLRT2 CCND2 ARHGAP1 OAS2 HEL-S-70p FASN CTH XPOT HEL-S-114 PFAS ACOT7 REXO2 KCTD14 CRYM TRAPPC3 CD200 RCC2 MAGED2 CACYBP SRGAP1 ACADVL SRM ELAC2 ACSL3 PMC8664701__F2 Nutritional therapy can reduce the burden of depression management in low income countries: A review CRH TNF PMC7726231__F3 Raptor silencing down-regulated components of mTORC1 (RPTOR, RPS15 A, RPS28) but not mTORC2 signaling in PHT cells TSC2 ULK1 TSC1 PC ELF3 RHO EIF4E MTOR EIF4B RHEB INSR PMC9200993__F2 Treg Cell Metabolism and Function in Non-Lymphoid Tissues GPX4 IFNA4 GCLC MTOR TFAM SIRT1 HMGCR CD36 FOXP3 PMC7817101__F8 Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKA stability via selective autophagy SUMO2 ANXA1 NBR1 PMC10487928__F5 Delta interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins IFIT3 PARP14 PML IFIT2 DHX58 PLK1 PARP10 F2RL1 H2BC3 CIT FBXO6 EPHB4 MX1 OASL ISG15 GBP1 OAS1 OAS3 GBP3 BNIP3L RAD51 CDC2 CTSL LAMP3 IRF7 APOBEC3B PTGS2 BST2 RIOK3 TRIM34 TRIM6 CDC45 HEL-S-102 TRIM14 KIF20A C4BPA HIST1H2AB EPHB2 H4C9 IFIT1 PMC6135718__F6 Potential lymphangiogenesis therapies: learning from current anti-angiogenesis therapies - A review ERBB2 EGFR MTOR PMC4523862__F8 USP18 negatively regulates NFKB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms TRAF6 MYD88 MAP3K7IP1 TAB3 USP18 PMC11121022__F1 Systemic sclerosis, recognized as a prototypical autoimmune disease, is intricately governed by a myriad of autoimmune mechanisms APC TYK2 HLA-DQB1 TNLG2B IL12A PMC4173667__F7 Schematic representation of a possible inflammatory pathway CD44 MYD88 PMC6813799__F1 Key Steps of Reverse Cholesterol Transport PLTP ABCG1 LDLR ABCB11 PMC8980436__F3 Cancer Metabolism: The Role of Immune Cells Epigenetic Alteration in Tumorigenesis, Progression, and Metastasis of Glioma SOX2 EGFR GSK3B MTOR STAT3 PMC8217759__F7 M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13RA2/MAPK Pathway in Rat Intervertebral Disc Degeneration MMP3 IL13RA2 MMP9 CHI3L1 PMC11754067__F1 Structure and formation mechanism of KL-la, KD-la and Kce SIRT2 GLO1 HDAC3 HEL-S-133P PMC8063606__F2 Pack a STRIPAK with hubs inside a hub YAP1 LATS1 LATS2 PMC8326263__F3 Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management IL17A VWF CCL25 MTOR PMC5388549__F9 Proposed mechanism for the effect of FPS-ZM1 in COPD HMGB1 S100A6 PMC8417791__F1 An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update ACE2 PMC4107617__F3 Group I mGluR-signaling pathway in immune cells FOS JUN IL1B PMC6887802__F2 COPD and autophagy pathway ULK1 EGR1 ATG3 GAL MTOR ATG14 PMC5828319__F4 CD200R-induced signaling pathway STAT1 SRC PMC5828319__F2 Inhibition mechanism of IL-12 production through interaction of TIM-3 and Gal-9 STAT1 TLR4 TEC SRC TRAF6 IRAK4 MYD88 STAT3 PMC6829368__F9 Network of the glutathione metabolism pathway OPLAH RRM1 GCLC SRM HEL-S-64p GGCT PMC6144915__F2 Pathway-pathway crosstalk via GADD45B GADD45B SMAD4 CDK4 PCNA CDK6 PMC9550190__F1 Conducive target range of breast cancer: Hypoxic tumor microenvironment SIRPA CD47 IL16 EGFR CCL5 CCL2 CXCL12 BNIP3 MTOR ARG1 HEL-S-133P STAT3 PMC9550190__F2 Conducive target range of breast cancer: Hypoxic tumor microenvironment CXCR4 EGFR CXCR5 CXCL12 STAT3 FOXP3 PMC7773221__F2 Common regulatory proteins of the complement and coagulation systems C4B_2 MASP1 APC MASP2 C1S PMC9266536__F1 Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule ELF2 RARB PDK2 PMC7024175__F1 CAMKK2 signaling pathway CAMK4 CAMK1 CAMKK2 PMC6639181__F9 Summary scheme represents the possible pathways of drug sensitive and drug resistance to cordycepin in MA‐10 mouse Leydig tumor cells ATF4 EIF2A ATF3 CDK4 MTOR XBP1 PMC4848973__F5 Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression HOXD10 CD44 BCL2 ARHA PMC8268881__F4 Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights RNF43 CDX2 SMAD4 GNAS PTEN CDKN2A PMC3479319__F1 Wnt signaling cascadesWnt signals can be transduced either through the canonical pathway (colored in pink) or different non-canonical pathways APC RHO MTOR JUN PMC6887802__F3 Lung cancer and autophagy pathway ULK1 MTOR PMC4991494__F6 Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer CREBBP ATM SMAD4 PRKDC INHBA PMC6887802__F4 Infectious lung disease and autophagy pathway ULK1 AMBRA1 TRAF6 MTOR ATG14 IFNG PMC6887802__F6 Pulmonary arterial hypertension and autophagy pathway ULK1 MTOR DKFZp686F0183 PMC6963221__F1 Sensing of Dengue virus by the innate immune responses and multiple evasion strategies to hinder the production of type I interferons (IFN).The upper panel shows the sensing of viral infection by RIG-I and cGAS TBK1 CGAS IKBKE XRN1 IFNAR1 TRIM25 MAVS PMC7708667__F1 Biglycan determines pro- and anti-inflammatory signaling response by switching between TLR2/TLR4/CD14 and TLR4/CD44 NLRP3 CD14 CXCL13 IL18 TLR4 CD44 MYD88 PMC6887802__F7 Acute lung injury and autophagy pathway ULK1 MTOR PMC8082393__F8 Comprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan–Dou–Fu–Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model UBC PLTP HEL-S-28 LPL SHE CPT2 PMC6498606__F7 Model of PAPP-A-driven PABC LARP6 DDR2 IGFBP5 PMC9359464__F4 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host TLR8 TLR5 TLR7 TLR4 TLR9 TRAF6 MYD88 TLR1 PMC10418609__F8 Expression of the DBNDD1 signaling pathway in prostate cancer (MetaCore) BAD FGFR1 NGF APC FGF2 GRB2 CREB1 RAC1 FRAT1 HTR2A IRS1 PMC4779130__F2 Signals involved in early granuloma formation CXCR3 MMP9 CXCL11 PMC9359464__F3 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host TNFRSF8 GADD45A TRIM27 PTPA PMC5603903__F8 Schematic diagram summarizing factors influencing the signaling efficacy of the TLR2/1-VDR pathway in response to TLR2/1 elicitation NR1i1 CSK DBP PTH TIRAP PMC7605288__F1 Caudal-related homeobox transcription factor 2 plays different roles in embryo, intestinal epithelium and colorectal cancers CDX2 ATM CDK2 APC GSK3B AXIN2 MTOR PMC4605623__F10 The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation CAMK4 CDC2 PMC9678611__F4 Prediction of network pharmacology and molecular docking-based strategy to determine potential pharmacological mechanism of Liuwei Dihuang pill against tinnitus NOG TLR4 EPO DAO VHL F11 TFRC HEL-S-87p HEL-S-133P TF PMC7429716__F1 G2/M checkpoint signaling pathway WEE1 CDK2 CDC2 ATR PMC4301714__F1 Simplified model of the Rag4-KlRgt1 glucose signaling pathway controlling RAG1 gene expression XK RAG1 ENO1 ENO2 PMC3465335__F4 Temperature Dependent Proteomic Analysis of Thermotoga maritima PMM1 HEL-S-162eP PMC4345858__F9 Acsl1‐dependent changes in metabolites in the biochemical pathway involving cysteine and glutathione metabolism CHAC1 pcap PMC12067746__F7 Graphical illustration of the working model SMAD4 INHBA FOXP3 PMC5464940__F1 MOA of CHST15/CS-E and STNM01 in tissue remodeling in IBD CCL2 PMC7818425__F6 Selected features and functions IL10 SCAP2 IL7R IL2RA SUMO4 CTSH PHTF1 GLIS3 PTPN22 PMC538777__F7 Novel Jun-Dmp1 pathway MYC MDM2 CCND1 CDK4 DMP1 PMC5419568__F5 Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNFA CDK2 SMAD2 CDK4 FADD CDK6 PMC8997587__F11 Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders HEL-S-30 PTBP1 BDNF PMC6628899__F1 Ipilimumab in prostate cancer APC CTLA4 PMC10420159__F1 Immune checkpoints in a tumor microenvironment (TME) HHLA2 HEL-S-92n CD80 LAG3 PMC3090458__F3 BAFF and APRIL signaling pathways in B cells TLR8 TLR7 TLR4 TLR9 TRAF5 TRAF3 TRAF6 MYD88 MAP3K7IP1 TRAF2 PMC6721552__F3 Simplified overview of the MAPK and PI3K pathway NF1 TSC2 TSC1 PTEN MTOR PMC3108097__F1 Iron Homeostasis and the Inflammatory Response TWSG1 EBP GDF15 HFE XBP1 TF TFR2 PMC6332843__F2 PD-1 signaling in B cells and T cells BCR ZAP70 SYK PLCG2 CD36 PMC7175146__F2 Structure of the neurovascular unit (NVU) with particular attention to the glucose metabolism impairment AQP4 S100B PMC8958553__F1 AKI and CKD affect FGF23 via inflammatory, iron deficiency, anemia, and metabolic related pathways FGF23 EPO IGF1 LCN2 IL6 LPA MTOR ORAI1 FOXO1 STAT3 PMC3995856__F4 Pathway analysis and molecular interactions of focus genes AKT, CTNNB1, GAB2, and SERPINE1 (hightlighted in pink) YAP1 CNKSR1 GAB2 DOCK6 PFKFB1 UXS1 MST1R PTPN13 HSPB8 INPP4B ACAP1 PMC7465203__F1 The Wnt pathway APC LRP5 LRP6 PMC11816803__F9 Figure illustrates simplified pathways involved in the development and progression of EC based on KEGG BRITE data (BRITE accession ID: K04503, pathway map ID: map05213) BAD POLK HEL-S-28 APC GRB2 CASP9 PTEN BAX PMC4292165__F1 Signaling pathway of cell surface TLRs TBK1 CD14 TANK IL1A IRAK2 NLRX1 TRAF3 IRAK4 MYD88 TLR1 TMED7 TLR4 IL1B TIRAP TAB3 CD36 PMC4292165__F2 Signaling pathway of endosomal TLRs TBK1 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IL6 MYD88 TNF TLR3 TLR8 TLR7 PMC4322524__F1 Signalling pathways that control maintenance of BCSCsWnt binds its co-receptors: Frizzled (Fz) and LRP5/LRP6 APC GSK3B LRP5 SHH LRP6 PMC6326667__F5 Environmental enrichment largely prevented age-SNCA-dependent disturbances and activated topologically relevant genes in the SNCA interactome with respect to both disturbance modes SPARC CD9 CTSS CRY2 MAOA HSD17B10 HEL-S-5 EIF3E NDUFAF1 CNTFR SERPING1 BHLHE41 PREX1 PGAM2 UQCRQ CTSL SNCA BHLHB2 COL18A1 NDUFA6 GFAP AIF1 RXRA LYRM4 ITGB4 MMP14 SLC18A2 HEL113 MERTK UNC5B Nucb2 CRTC1 MYLK PER3 MCTS1 HIPK2 C4B_2 INS CCND2 HIVEP1 GADD45B FCER1G C1QA HEL-S-67p ATM BASH NDUFA13 CIC RFXANK NDUFB6 PER2 ARHGDIB CRY1 EGR1 BST2 NDUFAB1 RPH3A TG PHGDH LRRC47 ID3 KCNF1 CDK2AP1 CASP3 C1QB BRSK1 RAF1 SMARCD1 TPT1 MEGF11 NPAS2 ADRBK1 PMC5354927__F1 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication CCL21 REST PMC5354927__F2 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication HDAC3 PMC4292165__F3 RLR Signaling pathway TBK1 USP4 CYLD TRAF3 TRIM25 RNF125 PMC9250200__F2 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis WNT3 ASNS AQP8 FAAH CDH2 MTOR PMC9250200__F3 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis NRG3 AMH FGF2 GDNF NRG1 MTOR BMP4 BOK PMC9250200__F1 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis GC FSHR MTOR PMC9405571__F3 Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases NLRP3 HMGB1 TFEB PARK2 ATG12 SIRT6 MTOR CFTR PMC10527326__F2 The Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis MITA KEAP1 CNPY2 IRS1 HEL-S-20 PMC8786701__F3 Impact of DNA testing on management of patients with colorectal cancer EGF EGFR PTEN MTOR PMC4697456__F1 CAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis CIRSR PRF1 GPR4 NRG1 PMC8698706__F10 Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid SMAD2 SMAD4 STAG1 CDK7 CDC45 STAG2 ORC2 MCM3 CDC20 MCM2 SMC3 CDK2 PCNA SKP2 MYT1 PMC4413232__F10 Sonic Hedgehog signaling maintains proliferation/self-renewal of cerebellar progenitor cells PRC1 SHH PMC12073286__F8 Schematic diagram indicating how SP protects ALD mice via the multi-target regulation of the CYP2E1/Keap1/NFKB signaling pathway KEAP1 CYP2E1 PMC3720830__F7 Cytochrome P450 1A1 Regulates Breast Cancer Cell Proliferation and Survival TSC2 TSC1 MTOR RHEB PMC5085755__F3 Functions of three members of the UBXD protein family (UBXN1, P47, and FAF1) that are potentially involved in the prevention of cancer UBXN1 TRADD TRAF2 FAF1 PMC10492287__F9 The metabolic pathway in placental cells GOT2 LAT2 PFKP HK2 PMC6098897__F2 Schematic diagram for the activation of BMPs, Wnt, and MAPK pathways by phytochemicals treatment RUNX2 MSC SMAD4 PMC4114922__F5 Function and regulation of the Rho guanine nucleotide exchange factor Trio CDH15 ARHG VCAM1 TBX3 RAC1 ETS2 TRIO PMC4114922__F6 Function and regulation of the Rho guanine nucleotide exchange factor Trio ARHA RAC1 TRIO PMC2556866__F1 Telomere structure and DSB processing RAD52 RAD51 ATR PMC4114922__F4 Function and regulation of the Rho guanine nucleotide exchange factor Trio FYN RAC1 DCC TRIO PMC4346946__F4 Regulatory mechanisms of actin dynamics in response to DNA damage LIMK2 JMY RHO PMC8983706__F1 High-throughput translational profiling with riboPLATE-seq TSC2 TSC1 EIF4E RPS6 MTOR PMC4346946__F3 DNA damage-induced molecular responses for DNA repair ATM ATF2 MDC1 H2AX BRCA1 PMC6330548__F2 The proposed genetic interactive network among genetic factors in lignin biosynthesis pathway, which exemplified by S‐lignin biosynthesis CAD RAN PMC9283012__F3 Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 and Its Related Molecules as Potential Biomarkers in Small-Cell Lung Cancer EZR VAV3 FYN DIAPH2 CACNA2D2 WASF2 LRP6 ROBO2 RGS2 TNF DDIT4 PPIF EDNRA MTMR3 EDNRB WASL PPP2CA BDNF MEF2C TH EPHA3 PRKCE SLC8A1 RASA2 TGFBR2 RELB CFL2 RYK ITGA4 ULK2 CACNB4 EPHB4 FGF20 FGF9 F2 ATP1B3 EPHA4 PDE3B SEMA3A ADRA2C LAMP2 RAB33B ARHA RAB7A MAP3K12 DDIT3 PIP4K2B ADRA2A TP53INP2 MAP3K2 EVI1 SEMA6B BNIP3 ADRA2B CAMKK2 PMC8616433__F4 Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy HMGB1 EGFR PMC10527059__F8 Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer’s Disease HES5 PRDM9 E2F4 CBX3 EP300 SMAD2 TGFBR1 NRARP PPARG GATA4 HES1 BRD4 PMC6830879__F4 Schematic diagram showing the major regulatory growth factors released by exosomes and the changes in tendon that occur aiding the healing process ANGPTL4 SMAD2 SPHK1 MTOR WNT5B PMC8233804__F1 Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus? CYP27A1 CYP24A1 CYP11A1 CYP27B1 PMC11116266__F2 JAK STAT signaling proteins in spondyloarthropathy and possible mechanisms of action of the JAK inhibitors EPO TPO IFNG PMC9117624__F3 Association Between Neddylation and Immune Response TBK1 CGAS IRF7 TRAF3 TRAF6 RIGI IRF3 MYD88 MAVS PMC3892798__F1 PD-1 in T-cell activation, exhaustion, and effector function APC CD80 PMC6323445__F3 FGFR1/FGF21/BKlotho complex actions in the cardiomyocytes FGF21 BAD FGFR1 UCP3 PMC10527059__F4 Predicted function of miRNAs interacting with circPSEN1s is summarized in this picture E2F4 ID4 SMAD2 TGFBR1 BACE2 INCENP SMAD4 LATS2 ID3 WTIP RNF157 GIG8 GJD3 PTMA MRPS15 PMC3774138__F1 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer TSC2 EEF2K BAD TSC1 MAP4K3 PTEN EIF4E IRS1 RHEB PMC4685736__F1 Tissue‐specific function of Blimp‐1 expression in dendritic cells IL16 GC IRF4 NOD2 PMC7522539__F4 Mood stabilizers and mt protein or pathway targets, as well as the schematic of precision psychiatry medicine PPP3CA DAO GSK3B MAPK14 HSPD1 MTOR DAOA CLU PRKCA RPL11 FYN OMD NDUFS1 UQCRC1 HDAC2 JUN HSPA4 SDHA RASD2 LRRK2 TUBB HEL-S-71 GSK3A FAAH JARID2 PFKL TNF RPS10 DBI CASP3 IMPA2 LEP NFKB1 BIK TNFRSF1A BCL2 HEL113 HEL-S-93 PPARG GNB1 SLC25A1 GLS PMC3774138__F2 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer TSC2 BAD TSC1 GRB2 PTEN EIF4E RHEB PMC7522539__F1 Conceptual systems framework in NPDs (BD/SZ/MD), and lithium treatment amelioration of mitochondrial (mt) functions in distinct pathways MARCKS BDNF PMC2654975__F1 Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease NUMB MSI1 HES6 MIB1 AP2A2 MAML3 JAG2 LFNG DLL3 LAG3 FBXW7 ADAM17 HES1 HES5 SIAH1 DLL4 MAML2 SPEN FURIN NCOR2 MAML1 PSEN2 DTX1 DTX2 DNM3 POFUT2 NEDD4 POFUT1 HEY2 PSEN1 NEURL2 ADAM10 PSENEN APH1B MIB2 MSI2 HES2 ITCH PMC3044403__F1 The GlcNAc and GalNAc salvage and O-GlcNAc signaling pathways NAGK OGA OGT GALK2 PMC3680934__F1 Activation of TAZ upon epithelial-to-mesenchymal transition in human breast cancer cells NF2 CD44 LATS1 LATS2 PMC4026397__F2 Role of NADPH Oxidases in Liver Fibrosis PTEN NOXA1 PMC2715000__F8 Summary of caspase 2-mediated signaling cascades in heat-induced germ cell apoptosis GEM MAPK14 BCL2 NOS2 BAX PMC8345975__F1 Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart MOB2 CDK5 NRG1 LATS1 PDK4 LATS2 CDK6 ERBB4 ERBB2 CDK2 CDK4 CDC2 CDK3 PMC5900062__F1 Canonical and non-canonical NFKB signaling pathways RELB TRAF3 TRAF6 IRAK4 PLCG2 MYD88 MAP3K7IP1 LEP CARD11 BCL10 BCR NFKB1 CYLD TRAF2 OTULIN TAB3 PMC4810982__F1 Proposed scheme for the protective effects of linagliptin against ABeta-induced neuronal insulin signaling blockade.GLP-1 is synthesized and secreted by neuronal cells DPP4 GSK3B SIRT1 PMC3296242__F8 Models of interactions within the destruction complex (A) and the catalytic cycle of the destruction complex (B) APC APC2 PMC4026397__F4 Role of NADPH Oxidases in Liver Fibrosis BAMBI TLR4 IRAK1 SMAD2 IRAK2 SMAD4 TRAF6 NOX4 IRAK4 MYD88 IL1B TIRAP PMC4275033__F1 Metabolic pathways that lead to the production of fatty acids and fatty acid-derived chemicals AHR DES FADD PMC5342869__F1 Regulation of the Hippo-YAP pathway by extracellular biophysical cues SLC7A5 LATS1 RHO LATS2 GAA SLC38A1 PMC2997573__F1 The current understanding of PELP1 signaling pathway EGF PELP1 EGFR SF1 SRC PMC4346946__F1 Nuclear entry of Cofilin-1 (CFL-1) via various stresses LIMK2 INO80 LIMK1 PMC6160231__F3 Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase FYN c-fgr WNK1 LCK LYN SRC PMC4226441__F2 Targeting the estrogen pathway for the treatment and prevention of lung cancer EGFR GRB2 SRC HBEGF TGFA PMC11945810__F1 Possible mechanism underlying hepatotoxicity CS TNF PAH PMC4553092__F1 The roles of various key members of the LRP receptor family; LRP4, LRP5, LRP6 and LRP8 in bone related traits and bone mass regulation KREMEN1 LRP4 LRP5 LRP8 LRP6 DKK1 PMC11945810__F2 Illustration of cell crosstalk and molecular pathways of different chemicals in the liver microenvironment AHR PAH PMC10041467__F1 Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease CYP27A1 AMACR BAAT CYP7A1 PMC4962009__F1 Replicative aging cooperates with other aging mechanisms to activate the p53 and/or Rb signaling pathways ATM CDK2 CDK4 CDC2 ATR CDK6 PMC8446424__F2 TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy SYK MTOR PMC7202281__F5 Interaction network of differentially expressed proteins between patients with pancreatic cancer and healthy controls, assessed by the Ingenuity Pathway Analysis software IGLL1 LBR ATM APAF1 VGF FLT4 IGFBP4 ENG TUBA1B TOP2A TGFB1 S100A6 PMC2721821__F6 Graphical representation of the Hh signaling pathway in its activated state and possible sites of HPI action SUFU PTCH1 SHH SMO PMC3205612__F1 Interplay between autophagy and intracellular pathogens ULK1 VASP ULK2 MTOR ATG14 MVP IFNG PMC10346484__F2 Key metabolic pathways for the biosynthesis of NEAAs, the enzymes in each pathway, and the main functions of each AA [54,173] BHMT2 PYCR2 PIG59 SHMT1 GPT GLS2 MTOR PAH HEL-S-61p MTR GOT2 AGA ADI1 GPT2 ASNS PSPH HEL-S-51e GLUD1 VPS29 PMC7568652__F3 CD40 pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time TANK TRAF5 TRAF1 TRAF3 ATF1 TRAF6 CD40 PMC7568652__F4 CNTF pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time CNTF CNTFR GRB2 MTOR PMC7553775__F7 Coordinated repression of A3B transcription by both E2F4/DREAM and E2F6/PRC1.6 complexes E2F4 E2F6 RBBP4 RING1 LIN9 L3MBTL2 TFDP2 TFDP1 RYBP LIN54 YAF2 LIN37 LIN52 PCGF6 MGA RBL2 RBL1 PMC10296091__F1 A2AR effects in microglia, astrocytes, and synapses under physiological conditions BDNF PMC10751873__F2 High expression level of CRNDE contributes to CRC by upregulating the signaling pathways such as Ras/MAPK, Wnt/Beta-catenin DUSP5 CDKN1A TCF7L2 HNRNPUL2 EZH2 ATAD2 PMC9523377__F3 Multifunctionality of Calebin A in inflammation, chronic diseases and cancer CXCR4 TNF STAT3 PMC6101248__F6 BPS-induced placental dysfunction working model GCM1 HYAL2 PMC6928850__F1 Molecular Characterization of XX Maleness IGF1R EMX2 LHX9 SIX1 DMRT1 POR WT1 FOXL2 SOX9 FGF9 SRY INSR FST RSPO1 SOX3 AMH WNT4 SOX13 SF1 TCF21 STAR AMHR2 SOX8 GATA4 SIX4 DHCR7 SOX10 PMC8534102__F3 Mental Illness and Amyloid: A Scoping Review of Scientific Evidence over the Last 10 Years (2011 to 2021) BACE1 APP PMC4814919__F9 Beta-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H FGF21 APOA4 PMC3310155__F1 Model of CaS receptor sorting traffic CASR RAMP1 RAMP3 PMC6617847__F5 Schematic outline of the salinity-induced response pathway based on proteome, gene expression, and physiological changes in chickpea leaves MYB MYC AVP PMC10751873__F4 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers CCNB1 CDK4 CDK6 CCNE1 PMC10751873__F5 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers RAP1A SRSF6 PICALM E2F3 PMC4918703__F1 The podocyte and the glomerular filtration barrier (GFB) MYH9 GRB2 ARHGAP24 TRPC6 HEL-S-47e INF2 ACTN4 MYO1E CD2AP PMC8151307__F10 Quo vadis Cardiac Glycoside Research? EGFR GRB2 SRC PMC7023272__F2 Resveratrol (RES) crosses the blood‒brain barrier via tight junctions MTOR STAT3 PMC3526508__F2 Becoming a follicular or a MZ B-cell? NOTCH2 BTK BCR PMC6429457__F4 Upstream regulator analysis of the differential proteome of the spleen from 11-week Npc1−/− mice TCL1A MMP9 SNX6 C1QC MPEG1 HEL-S-130P GUSB GPNMB PMC6451240__F1 Phagocytic pathway in glial cells XCR1 VPS35 TLR4 LRRK2 CD33 CX3CR1 SYT11 MEGF10 AXL CR1 RAB10 PMC4167320__F1 Overview of the extrinsic, intrinsic, and phagocytosis-induced apoptotic pathways CASP3 CASP9 PCNA PMC8072665__F4 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach CCNA2 THBD ALB MYC ALOX12 MAPK14 APOD BCL2L1 SLPI HIF1A PTGS1 HMOX1 MMP2 CD163 IRF-1 CXCL11 MMP10 FOS TP63 CXCL10 VEGFA ADRB2 GRIA2 PRKCB ABAT CTRB1 CDK2 HEL-75 NOX5 CHUK MPO MAP2 RUNX2 COL1A1 PLAT E2F2 opn F3 CCND1 ABCG2 SELE FASN BAX CD14 MGAM NFATC1 PCOLCE CXCL2 GSTM2 AHSA1 SLC2A4 LBP PPARG PMC8072665__F5 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach HSPA14 RPA3 NPM1 FLNA MYC BMI1 RPL13 RPS7 RB1 MAGOH HIF1A RPL31 LIMA1 RPS19 MDM2 RPL23 SNW1 ILF3 MAPK1 RPS27 EZH2 SNRPA1 SP1 NCL SET TUBB EEF2 LMNA BRCA1 TUFM PAN2 PAK1 MCM2 CDK2 GRB2 CLTC HEL-S-100n VCP RPS3 PCNA MYH9 PML HEL2 UBC RPS2 F2 APP CDC2 YWHAG PRKDC JUN RUVBL2 KAT2B RPS14 FBL HEL-S-30 YBX1 RPA1 RPL38 VHL RPL6 CDC37 RPS11 RPS8 RPS9 FUS PS1TP5BP1 RPS3A HEL-S-162eP EED SIRT7 C1QB CREBBP EP300 AHSA1 KAT2A NOP56 RELA TRIM28 PMC3545710__F5 Suggested pathway PIM1 NFATC1 STAT3 PMC6226322__F7 ZFPM2-AS1, a Novel lncRNA, Attenuates the p53 Pathway and Promotes Gastric Carcinogenesis by Stabilizing MIF BAX PMC6928850__F2 Testicular and ovotesticular differentiation in XX foetuses AMHR2 DMRT1 WT1 FOXL2 SOX9 FGF9 SRY RSPO1 SOX3 AMH WNT4 SF1 SOX10 PMC9094073__F1 Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy TSC2 TSC1 RHEB PMC6387020__F6 Representative liver disease pathway BAD CASP12 TRADD KEAP1 MMP9 EGFR MAPK3 NFE2L2 GSK3B TNF MTOR RXRA CASP3 NFKB1 RELA GRB2 CASP9 BCL2 MAPK1 TRAF2 PMC7564998__F1 Oxidative stress, mitochondrial dysfunction, axonal transport, and glutamate excitotoxicity in amyotrophic lateral sclerosis (ALS) VAPB SETX ATXN2 NEFH VCP OPTN FUS PMC6387020__F5 Representative cardiovascular disease pathway HEL-S-102 PRKCA BAD PTGS2 MAPK3 MAPK14 CASP9 SRC MAPK1 PTGS1 CDC42 CACNA1C PMC8922476__F3 Gut-brain axis of CCM disease TLR4 KLF4 KLF2 PDCD10 PMC3408345__F6 Glucocorticoid (GC) actions in the airways epithelium STAT1 STAT2 IRF7 PPARGC1A IRF9 IRF3 RXRA PMC1199368__F5 Candidate genes that are involved with the metabolism of androgen and estrogen SHBG NR3A2 STS HSD3B1 CYP11A1 HSD17B1 LHB UGT2B15 HEL-S-22 PMC2885703__F11 WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death GSK3B PTEN BAX PMC4017675__F5 In sum, there is a critical clinical need for better understanding and treatment of inflammatory airway disease in general, and mucous cell metaplasia in particular MUC5AC MUC19 MUC5B PMC2896964__F1 Schematic representation of the possible interactions between HIV-1 and the host miRNA-guided RNA silencing pathway AGO2 DGCR8 DROSHA PMC3830884__F4 MAP kinase signaling pathway of sugarcane infected by S GLO1 CDC42 PMC11999627__F2 IL-33/ST2 signaling pathway IRAK1 SIGIRR IL33 TRAF6 IL1R1 MYD88 TAB3 PMC6482944__F2 Molecular regulation of PFGA in Mice KIT LIF BMP7 PTEN MTOR RHEB BMP4 TSC2 KL IL16 TSC1 AMH GDNF CXCL12 PMC5938816__F11 Gene expression pattern related to TLR4 signaling pathway following epileptic seizure IL10 TLR4 IRF3 MYD88 PMC3797650__F1 Diagram of hedgehog (Hh) signaling in mammalian cells EGF BOC KIF7 GPC3 SAG RAB23 BMI1 WIF1 SUFU NRP1 MDM2 CCND1 BCL2 SMO ABCG2 ADRBK1 STAT3 ITCH PMC3959213__F6 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway ENO1 HEL-S-87p HEL-S-162eP PMC11545656__F1 Scheme of CD95 pathway APAF1 FADD BAX PMC4581331__F4 Biological mechanisms of MALAT1 in CRC SFPQ PMC11545656__F2 Scheme of CD95-mediated apoptotic and non-apoptotic signaling RIPK1 TRAF2 FADD PMC3959213__F1 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway ENO1 HEL-S-87p HEL107 HEL-S-162eP PMC4143117__F7 Dynamics of BMP Signaling in Limb Bud Mesenchyme and Polydactyly COL2A1 COL9A1 SOX9 PMC3578363__F4 Targeting ubiquitin-dependent degradation of CDK inhibitors CDK2 SKP1 SKP2 PMC3578363__F1 G1 cell cycle control by the pRB pathway CDK2 CDK4 CDK6 PMC2396785__F2 Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle SRC RHO CDC42 PMC5171903__F9 GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment FGFR1 FGF2 SOX4 PMC6964670__F2 Analysing IDO1 inhibitors clinical trial results IDO1 COX2 KYNU AHR IDO2 TDO2 IFNG PMC5834400__F1 Apoptotic signaling through the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) pathway BCL2 DIABLO FADD BAX PMC5832419__F5 Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors GPX3 GCLM PC GPX1 HEL107 PMC3844062__F2 Proposed pathway for NLRP3 inflammasome activation during viral respiratory tract infection NLRP3 IL1B PMC6240570__F1 Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches SUFU APC SMO PMC7503838__F11 Therapeutic targets for brain injury for nanoparticle mediated drug delivery EPO NPS BDNF PMC8787930__F1 Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer CD47 PC PMC2810509__F3 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7693462__F5 NAA and citrate pathways to acetyl-CoA NAT8L ACSS2 ACLY ASPA PMC3338129__F2 Crosstalk Between Reverse Cholesterol Transport and Innate Immunity TLR9 IRF3 MYD88 TNF TLR1 TLR3 ADAM17 TLR8 TLR7 TLR4 ABCG1 ABCA1 STAT3 PMC7693462__F6 NAA as a selective, alternative cytoplasmic and nuclear acetyl-CoA source NAT8L CIC ACSS2 ACLY ASPA PMC11557815__F3 Impact of P CXCL16 RUNX2 IL13 MYOCD CCL5 IL6 PECAM1 PMC7876332__F7 Scheme about the central role of erianin in ferroptosis induction and migration inhibition CDK2 CDK4 MTOR BAX PMC8112288__F1 Insights on the mechanisms of action of ozone in the medical therapy against COVID-19 MAF KEAP1 PMC9220264__F3 Focus on the Contribution of Oxidative Stress in Skin Aging GPX1 NQO1 PMC3675894__F2 Summary of association of genetic alterations of the HH pathway and cancer type SUFU SHH SMO PMC2496917__F1 Interfering the PI3K/mTOR/p70S6K signaling pathway PI3 PTEN MTOR PMC2871738__F2 Molecular determinants of mitochondrial quality-control networks MFN2 AUP1 MEN1 FIS1 NBR1 GABARAP OPA1 PMC2871738__F3 Role of the major PD-associated genes in mitochondrial dysfunction PINK1 PARL BAX PMC6710038__F7 Schematic model of the mechanism that MIR210HG promotes tumorigenesis and metastasis through a ceRNA pattern in IBC patients SMAD2 PMC6377292__F1 Transcriptional and epigenetic regulation of microglia in health and disease BHLHB2 MAFB RUNX1 CX3CR1 IRF7 IRF8 SALL1 CTSH MX1 CSF1R MIA TMEPAI AXL MEF2C APOE PMC10542901__F1 Endothelium as initiator and target of type I IFN responses TBK1 STAT1 CGAS STAT2 IRF9 CXCL10 IRF3 TNF IRF-1 PMC9315706__F1 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target ULK1 ATG12 ATG3 AMBRA1 BCL2 ATG101 UVRAG BNIP3 PMC6359907__F4 Selective autophagy as a potential therapeutic target for neurodegenerative disorders RARA TFEB ATG12 PHLPP1 PMC9315706__F5 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target ULK1 AMBRA1 ATG101 ULK2 PMC3675657__F7 Mechanisms for iron-dependent and iron-independent IRP2 regulation SKP1 CDC2 RBX1 FBXL5 PMC5402004__F10 Schematic signal transduction network representing the observed changes in protein and lipid metabolism in eWAT during sepsis-recovery TSC2 NLRP3 ULK1 TSC1 ATG12 UCP1 ATF4 EIF2A EIF4E DKFZp686F0183 RHEB PMC6770250__F1 Basics of transforming growth factor B (TGFB) signaling SMAD2 SMAD4 SKI PMC6770250__F2 TGFB signaling in cholangiocarcinoma (CCA) progression SMAD2 AK4 PMC2810509__F2 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN RHO ITGB1 PMC6401655__F1 Subcellular localization and function of the eukaryotic LSM complexes LSM8 LSM5 LSM7 LSM6 LSM4 LSM2 LSM1 LSM3 PMC9643504__F3 Hippo signalling pathway and its implications in human health and diseases NLK AMOT BMP2 NF2 SCRIB SIAH2 PMC9643504__F2 Hippo signalling pathway and its implications in human health and diseases TEAD3 WWC3 WWC1 TEAD4 LATS1 WWC2 LATS2 TEAD2 PMC8065698__F2 UPR drives pro-inflammatory responses to ER stress TLR4 NOD1 EIF2A MYD88 RIPK2 TNF TRAF2 XBP1 NOD2 PMC9059347__F1 Constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection ACAT1 LDLR PMC5389695__F3 SUMO as a regulator of PCNA ubiquitylation and repair pathway choice RAD18 PCNA PMC6042961__F10 FRMD8 stabilises the iRhom2/ADAM17 sheddase complex at the cell surface EGFR ADAM17 PMC3024260__F1 Computational and Experimental Study of the Regulatory Mechanisms of the Complement System HEL-S-62p PC C4B_2 CRP C4A PMC8510680__F6 SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF-1A SETD7 LATS1 HEL-S-133P SOX9 HEL-S-68p PMC8486678__F1 Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19 CTSL ACE2 TMPRSS2 PMC8073279__F1 Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women DHFR PMC3656432__F4 Myostatin (Mstn) pathway SMAD4 MSTN PMC4928187__F2 Map of lipid metabolic pathways in C MTAP PC SCD PGP HEL-S-44 LPA PSD HEL-S-5 PMC9406587__F3 Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1 ELF2 ATF4 MTOR XBP1 PMC7677084__F9 Network diagram of two pivotal pathways for muscle development in KEGG enrichment analysis BAMBI PRKCE WNT16 PPP3CA NFATC1 ATP1B4 RGS2 RBX1 NFATC3 DVL1 PLCB1 CCND2 NLK MMP7 LEF1 ADRA1B MYLK2 WNT10A MEF2C MYLK PMC11496173__F4 Molecular mechanisms of Keap1-dependent and Keap1-independent modulation of Nrf2 MAF KEAP1 DLD PMC11496173__F5 Probable mechanism of action of ISL on the Nrf2 pathway NLRP3 KEAP1 CSA2 SIRT1 NQO1 PMC5727596__F2 Influence of chosen compounds/proteins on the Wnt signaling pathway which are under consideration as either potential therapeutic targets (continuous line) or potential therapeutic/adjuvant agents (dotted line) PAK1 DKK1 BMP4 PMC3983869__F1 Beta-Catenin is a multifunctional protein that localizes at cell-cell contacts, the nucleus, cytosol and centrosomes APC GSK3B PMC10310354__F2 Function of Akkermansia muciniphila in type 2 diabetes and related diseases UCP1 ADFP FGF19 APOE PMC10389837__F3 Research Progress on the Etiology and Pathogenesis of Alzheimer's Disease from the Perspective of Chronic Stress BACE1 CRH GSK3B CDK5 PMC4026077__F1 Inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells HHIP PTCH1 GLI3 MYC SMO KCTD11 PMC9603545__F1 Wnt Signaling and Aging of the Gastrointestinal Tract APC LRP5 LRP6 PMC3960487__F2 Signaling pathways involved in YPP regulation TSC2 RICTOR TSC1 PTEN RHEB PMC2714639__F6 MT1-MMP expression in first trimester trophoblasts is stimulated by insulin, IGF1 and IGF2 by different signalling pathways IGF1R IGF1 IGF2 PMC7693462__F4 Hypothesized role of NAA in cancer cells as an alternative source of acetyl-CoA for specific transcription factor acetylation in place of citrate NAT8L CS EPO ACSS2 ACLY ASPA SIRT1 PMC8166058__F5 Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer NF1 SPRED1 SOS1 PMC9273332__F1 Single-cell deletion analyses show control of pro-T cell developmental speed and pathway by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b CAP2 KIT HOXA9 CAP1 ATL1-beta SPI1 ERG MEIS1 CD44 BBS1 GATA3 PMC3328302__F7 Schematic diagram illustrating the proposed interaction between CDH17 and Wnt/Beta-catenin pathway during HCC progression COX2 APC CCND1 PCNA PMC5768892__F6 Gcn5−/− EBs becomes evident early during EB differentiation SPRY4 BCAT1 NMNAT2 SRM MYC GLDC GRB10 MTHFD2 RPS6KA2 INSR STAT3 PMC8946903__F12 Spermatozoal Mitochondrial Dynamics Markers and Other Functionality-Related Signaling Molecules Exert Circadian-like Response to Repeated Stress of Whole Organism MAPK9 NRF1 UCP1 MAPK8 MAPK3 PRKAR1A MAPK14 PPARGC1B UCP2 MFN2 MAPK12 PPARGC1A MAPK1 TFAM FIS1 OPA1 MAPK7 ADCY8 NR1C1 PINK1 MAPK13 PARK2 MAPK6 TFEB NR1C2 ADCY5 MAPK11 UCP3 PMC2705999__F3 Castration-Adapted Prostate Cancer: Targeting Androgen Metabolic Pathways in Recurrent Disease STS CYP11A1 AKR1C1 CYP7B1 UGT2B17 CYP17A1 UGT2B15 PMC209413__F1 The TGF-&bgr;/Smad pathway and its interrelationship with mediators of inflammatory signals STAT1 SMAD2 SMAD4 JAK1 NOD2 PMC8824786__F1 Functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation SMAD2 TGFBR1 TGFBR2 SMAD4 PMC9066914__F6 EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes EGF APC EGFR SOX10 OLIG2 PMC5851616__F9 Tilianin improved myocardial apoptosis HTRA2 BAX PMC6714585__F1 Hedgehog signaling pathway SUFU PTCH1 GLI3 MYC SHH SMO PMC11585128__F7 Secondary BAs regulate liver TH17/Treg cell differentiation to maintain NASH tolerance GCA CD44 TRAF6 UGT8 S100A9 IL23R BAAT HMGCR CD69 FOXP3 CYP8B1 FOSB ABCC2 JUN SULT1C2 CD3E FABP1 PMC4231374__F1 Hypothetical representation of PI3K/AKT/PTEN signaling in pancreatic Beta-cells is shown, which modulate NOXs-derived reactive oxygen species (ROS) generation TSC2 TSC1 GSK3B PTEN HIF1A MTOR PMC8598044__F1 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion TRAF6 IRF3 MAVS PMC7474398__F6 Distribution of target proteins of the QX1 formula on the integrated “cardiac disease-related pathway.” The cardiac disease-related pathway contained calcium, MAPK, PI3K/AKT, and Toll-like receptor signaling pathways EGF CHUK BAD EGFR MYC TRAF6 PTEN MYD88 TLR4 MDM2 CHRM2 NOS2 JUN IL1B CD14 GNE IL6 TNF MAP3K7IP1 RXRA PLN LBP GRB2 BCL2 GNAS TRAF2 TIRAP ELL PMC8189631__F6 NRF2 induction via FAM129B in mutant BRAF cells GCLM KEAP1 GCLC POMP RAD51 NQO1 MAFG PMC8598044__F2 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion TBK1 STAT1 TLR9 STAT2 IRF3 PTEN MAVS PMC8598044__F3 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion TBK1 IRF3 LRPPRC MAVS PMC8598044__F4 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion STAT2 IRF9 TYK2 JAK1 PMC7471444__F5 Comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC8469349__F7 Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499 SMAD2 SMAD4 DMD PMC545911__F1 Phosphoinositide kinase specific genetic interactions ARL1 VPS41 ARF1 SYS1 VPS51 PMC8818945__F10 Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells BCL2 NQO1 BAX PMC1698524__F5 Model linking HSP70 induction to p33ING1b-induced apoptosis TRADD RAN FADD BAX PMC8629365__F2 Schematic presentation of local translation regulation in dendritic spines of glutamatergic synapses of hippocampal pyramidal cells in response to synapse stimulation TSC2 TSC1 RAF1 EIF4E HRAS RHEB PMC5882662__F6 Metabolic pathways related to the differential metabolites identified in the BDE-3 groups CPT2 GIP HEL-S-5 PMC4399989__F8 Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents TG NR1C1 PMC9536090__F5 Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system ALK EGFR BRCA1 PMC11079208__F5 Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies BMP6 TPM1 RECK FAP TIMP3 IL6 PTEN STAT3 PMC11079208__F3 HER-2/EGFR signaling pathway in breast cancer SMAD2 EGFR SMAD4 PMC6449624__F2 BTLA-associated signaling pathways (stimulatory/inhibitory) regulate the outcomes of HBV-ACLF, liver graft tolerance/rejection, liver cirrhosis and hepatocellular carcinoma CD160 GRB2 BTLA PMC3413220__F1 LCAT functions potentially affecting the pathogenesis of cardiovascular disease APOB ABCG1 ABCA1 PMC7230342__F4 2-step DSB repair pathway choice model [,,] ATM BRCA2 RAD51 PMC12213698__F1 Basics of the canonical Wnt signaling pathway APC LRP5 LRP6 IL4 IL1B IFNG PMC12213698__F2 Basics of the noncanonical Wnt signaling pathway APC LRP5 LRP6 PMC2788255__F6 Wnt signalling pathway downregulated in osteosarcoma PRKCI FZD3 PRKCZ CTBP1 APC MYC FZD4 FZD1 DVL3 DVL1 NLK LEF1 FZD2 FZD7 FRAT1 JUN PMC6580171__F4 Human intermuscular adipose tissue (IMAT) revealed a downregulation of key pathways associated with insulin resistance FHL1 PIK3CD EGF COX1 MYC BCL2L1 MTOR CCND2 AOX1 STAT1 PIM1 ZNF183 NDUFS1 NDUFA12 CNTFR NDUFA13 MIA PTPN11 COX7B CSF2 SDHA SDHC NDUFV2 IRF9 GFAP NDUFB2 NDUFAB1 CYB HRAS CNTF ND6 CREBBP COX17 NDUFB1 CISH ND3 ND1 ND2 CYC1 GRB2 BCL2 JAK3 NDUFA10 MCL1 RAF1 SOS1 ND4 SOCS1 PMC4167640__F2 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment PATJ HIPK2 AMOT ZYX NF2 AJUBA SCRIB LATS1 RHO MOB1A MOBKL1A WBP2 PMC4167640__F1 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment LATS1 MOB1A MOBKL1A LATS2 PMC11040299__F1 Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer's disease RIPK1 TRADD RIPK3 TNF FADD MLKL PMC11603026__F4 Drug repurposing discovery in Mpox infection EP300 CRK BATF PMC5552148__F2 Generation of ROS as a result of incident radiation affecting the mitochondrion.Notes: ROS have been shown to form oxidative DNA adducts, such as 8-OHdG, which in turn can lead to base modifications and transversions, such as GC to TA COX2 ATM ATR PMC7188831__F3 Adaptors of Salmonella autophagy TBK1 OPTN RNF166 PMC5925168__F2 Pruritic signaling pathways PLCB3 MRGPRD TRPA1 TRPV1 ITCH PMC4935219__F1 Cellular and molecular targets of MTX, 5FU and irinotecan in the small intestine of the AT HGF CDX2 SI GATA4 PMC11821285__F2 Proposed molecular mechanism of ARI in cancer involving modulation of Hippo signaling and Wnt signaling pathway APC LATS1 PMC11821285__F3 Proposed pathways and molecular interactions for ARI's anticancer effects SRC MTOR HTR2B DVL3 STAT3 PMC7998946__F2 Metabolism of activated T cell and the effect of cancer-induced tumor microenvironment (TME) acidification on T cell response HEL-S-87p HEL-S-133P HK2 HEL-S-162eP PMC11603026__F5 Mpox’s role in antiviral and proviral cell signaling regulation TH CGAS FAR1 RP1 PMC11603026__F6 Mpox manipulation and activation of proviral signaling via AKT, Wnt, and STAT3 signaling pathways TBK1 BAD HIPK2 SOCS3 IRAK2 GSK3B IRF3 COX2 CDK4 TRAF2 JUN STAT3 BAX PMC2787730__F10 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway VASP FYN HEL-S-28 ARHA PTEN CRK PMC9561344__F1 Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy SMAD2 TGFBR1 SMAD4 ARHA CCL2 PMC2787730__F11 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the apoptosis pathway BAD NGF TRADD ATM MYD88 TRAF2 FADD BAX PMC2787730__F12 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cell-adhesion pathway CD58 TH CD99 CD6 ICAM2 ESAM ITGA4 SPN SELL CD2 PECAM1 ICOS SELE APC CTLA4 ITGB1 PTPRC ITGAM ICAM3 ITGB7 VCAM1 CD22 GLG1 CD40 SELP CD226 JAM2 PMC3969740__F2 A) Pathogen recognition receptors RIG-I and TLR3 detect HCV ds RNA and activate via their adaptor molecules IPS-1 and TRIF STAT2 IRF7 IRF9 EIF2A IRF3 TLR3 PMC4383314__F3 Serum starvation induces changes to cellular metabolism and chromatin remodeling proteins FAHD2A HSD17B12 ASF1B HDAC3 CHAF1B NPM1 CTCF CENPF MTA2 GCDH ACOX1 FDPS KAT8 KDM5C MEN1 HMGB2 NASP NDUFAB1 RNF2 HMGCS1 HEL60 HMGA1 CBX1 CBX8 SLC25A3 MVD FADS2 DHCR7 UQCRH CHD8 KDM4A PMC9500245__F6 Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients FOXP3 PMC10040598__F1 The inflammasome in insulin resistance and type 2 diabetes mellitus GRB2 MTOR IRS1 PMC8630042__F1 RAS/MAPK pathway downstream signaling and therapeutic targets NF1 RRAS MTOR RHEB PMC5365060__F3 Biosynthesis of high-carbon sugar nucleoside antibiotics POLK POLG POLI PMC8286267__F7 HBcrAg species, biogenesis, and application as biomarkers to monitor HBV gene expression and replication during natural resolution SHB LHB PMC7566002__F9 A possible molecular network between RASSF1A, the Hippo pathway effector YAP1, AKT, FOXO3A, FOXM1, and ERA based on the findings in this paper and on the published literature PLK1 FOXM1 YAP1 CDK2 CDK4 CDC2 CDK6 PMC2080907__F8 Myc and Ca2+signaling events downstream of the pre-BCR/BCR BTK FYN BCR BIK LYN MYC TEC SYK PLCG2 BLK PMC9399422__F6 Identifying gene variants underlying the pathogenesis of diabetic retinopathy based on integrated genomic and transcriptomic analysis of clinical extreme phenotypes PAPSS2 SLC38A11 ARHGAP20 PLEKHG7 BMP2 POM121 TMEM119 MCAM EVC2 OTOR CUX2 ARHGEF17 NPHP3 IL1B PMC11002909__F2 Antiviral role of ubiquitination in enterovirus infection TRIM38 TRIM7 TRIM21 IRF3 TRIM25 MAVS TRIM65 PMC9162468__F2 Therapeutic strategies to induce mitophagy PINK1 ULK1 USP30 PMC6463794__F6 Summary of the proposed inhibitory mechanisms exhibited by WG-391D in ovarian cancer E2F4 CDKN2C TGFBR1 CDK4 CDC25B SP1 CDK6 PMC7347881__F7 Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling HES5 RBPJ PDGFRA ASCL1 RIN1 MYC NEUROG2 PMC10382180__F3 Immunity by tryptophan microbial metabolites AHRR AHR CYP1B1 CYP1A2 PMC5751200__F2 The BMP-2 signaling pathway plays an important role in the osteogenic differentiation of adipose-derived stem cells (ASCs) RUNX2 BMP2 SMAD4 SMAD1 PMC3058926__F4 Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations CARF EGR1 CREBBP CDKN2AIP RELA RELB LAT PMC6433978__F2 Complement activation pathways and examples of complement-targeting therapeutics for IgAN HEL-S-62p CFHR3 C4B_2 CFHR4 CFHR5 C4A CR1 CD59 CFHR2 C9 FH C7 C6 CFHR1 PMC4795442__F1 Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis HEL-S-62p MPO HLA-DRB4 PMC8941137__F10 Beta-cell fitness comparison in Beta-cell replenishment under stress MCM2 HIF1A PMC7998946__F1 Schematic comparison of metabolic pathways between a nontransformed cell and a cancer cell TRO HEL-S-87p HEL-S-133P HK2 HEL-S-162eP PMC7139113__F1 Network for the genes included in mitochondrial functioning processes KIF1B NRF1 PARK2 ZNF746 PMC5366901__F4 Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients PGR FOXA1 GSK3B PMC3995778__F4 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies SLC9A9 SHANK1 GRM3 PIAS1 GRIN2B SHANK2 GRIA2 PMC3995778__F5 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies INA TRPC1 GLS PMC9295998__F1 Multi-scale model construction GPX3 YAP1 GPX2 GPX1 HEL-S-44 MSH2 DDT DPT PMC6562738__F5 RAC1 signaling in tumor cells: RAC1 signaling in tumors cells and the involvement of the RAC1 protein in tumorigenesis and drug-resistance as presented in the review TIAM1 PAK1 GRB2 SRC BCL2 GIP RAC1 MTOR PREX1 CRK PMC5094987__F7 EZH2-mediated repression of GSK-3B and TP53 promotes Wnt/Beta-catenin signaling-dependent cell expansion in cervical carcinoma APC WNT1 GSK3B EZH2 SUZ12 EED PMC1940051__F2 TGFB signaling pathway HGF SMAD2 TGFBR1 SMAD4 PMC4100138__F2 Autophagic cell death in lung tumor cells ULK1 PTEN ULK2 MTOR PMC4237677__F3 Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders F2 F3 RAN PMC4632830__F1 Heme biosynthesis pathway (in red) connects with glucose (in green) and glutamine (in blue) metabolic pathways FECH UROD UROS CPOX PMC3634451__F2 FGF signalling cascade in Drosophila melanogaster GRB2 GIP CDC42 PMC7862465__F2 Glycosylation changes in TGFB activation and SMAD-dependent pathway SMAD2 SMAD4 PMC4256494__F3 A, Cellular arginine metabolism and putative role of arginase in the development of renal fibrosis ARG2 PRODH ASL PMC4063399__F2 Resistance to vemurafenib HGF BRAF PMC4611759__F1 Type I IFN gene expression TBK1 TLR7 IRAK1 IRF3 IRAK4 MYD88 TLR3 PMC4611759__F2 Cellular response to IFNs STAT1 ADAR TYK2 JAK1 PMC4349729__F2 Simplified view of insulin/IGF1 signaling IGF1 IGF2 GRB2 MTOR INSR PMC4050971__F3 Ingenuity Pathway Analyses: Pathway analyses were from the commercially available Ingenuity Pathway Analysis software NGF IRF7 RASGRF2 TRPC5 ATF3 ZNF230 SSTR4 CP PMC4084493__F2 Non-homologous end joining: emerging themes and unanswered questions ATM BRCA2 ATRIP SSB RAD51 ATR PNKP DNA2 PMC4050971__F4 Ingenuity Pathway Analyses: Details are as in RPS4X RTKN DEDD TNNT1 CADM3 RHO CADM4 GPR108 ZC3H15 PHF23 FAM219A TMEM98 PTCH1 ARRDC3 CP PMC4720263__F4 Signaling crosstalk between the TGF-Beta-activated Smad pathway and the Wnt- and Notch-activated signaling pathways during EMT LEF1 SMAD2 GSK3B SMAD4 PMC8030716__F1 Entry of the virus leads to activation of the innate immune system which comprises of macrophages and dendritic cells PDC APC CD40 CD80 MYD88 TNF PMC2721684__F1 Signaling pathways triggered by TLR3, TLR4 and TLR1–TLR2 TBK1 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR3 TIRAP PMC4812151__F2 Signaling pathway and biological function of Rap2B, a Ras family small guanosine 5′-triphosphate-binding protein RAP2B TNIK GIP HEL-S-31 PMC5362762__F5 Exploration of small RNA-seq data for small non-coding RNAs in Human Colorectal Cancer APP PTEN PMC11610194__F7 Regulatory networks of critical pattern pathways PIK3R1 CCNA2 FZD3 SOST CXCL8 BCL2L1 DKK1 IL6R CACNA1C CCR1 SCIN LAP3 CLCF1 GPX2 FGF10 PTK2B NTRK2 FZD10 SFRP4 PRKCQ CREB3L3 VEGFA CALML4 CHAC1 IRS1 WNT10B CDC6 TRAF1 RYR1 HEL-S-64p HEL-75 BCL2 TNFAIP3 BDNF LAT AKT3 PLCG1 PRKCE CCR6 CCND3 AOX1 PDGFD GNB3 TICRR KIT PPP2R1B FLT3LG ADCY8 IKBKB CARD11 LEF1 MARCKSL1 RELA ZAP70 PIK3CA ORC1L SYK JAK1 CTNND2 SKP2 PMC2693146__F8 Model depicting the dual role of cGKI in BMP signalling pathway cGKI regulates BMP signalling through (light blue) modulation of BMP receptors at the cell surface and enhancement of R-Smad phosphorylation and thus Smad activation BMP2 SMAD4 ID1 PMC8764205__F8 Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts ROCK2 NFATC1 CDK5 DVL2 ROR2 SIN3A RAC1 WNT5B DVL3 ROR1 TF CDC42 PMC6770048__F1 Proposed biosynthetic pathway leading to multiple terpenoids in I AACS MVK IPP PMC7061741__F4 Schematic diagram shows the proposed mechanism by which the Hippo pathway regulates cervical cancer AREG EGFR LATS1 TGFA LATS2 PMC8533819__F3 Involvement of Kynurenine Pathway in Hepatocellular Carcinoma IDO1 AHR IL6R STAT3 FOXP3 PMC7061741__F5 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates ovarian cancer FGFR1 AMOT AREG EGFR FGFR3 FGFR4 LATS1 LPA FGFR2 PMC7061741__F6 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates endometrial cancer EGF IGF1 GAB2 CCND1 LATS1 LSR LPA CDH2 USP51 LATS2 FAT4 PMC2719108__F2 Schematic representation of the renin angiotensin system REN DAP ATR ACE2 PMC7061741__F7 Schematic diagram showing putative targets and small molecules specific to the Hippo pathway AMOT LATS1 LATS2 PMC4086823__F3 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage CASP3 CASP9 BAX PMC4086823__F1 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage CASP3 ATM MDM2 CASP9 BAX PMC4715999__F2 Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: implications for disease pathogenesis and treatment CD5 CCL4 PLCG2 CD79B CD79A BTK BASH CD22 LYN SYK TF CD19 CCL3 PMC7368967__F10 Mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation BMPR2 GIG8 HDAC2 MTOR SMAD1 HDAC1 DKFZp781O1323 PMC7061741__F2 Hippo pathway in mammals TEAD3 SMAD2 TEAD4 LATS1 CAD SMAD1 TEAD2 PMC12038455__F1 Implication of miR-21-5p and miR-214-5p in regulation of signal transducer and activator of transcription 3 signaling pathway MSC STAT3 PMC5864227__F1 Mutp53 accumulation in tumours is sustained by mechanical inputs through a mevalonate-RhoA-HDAC axis MDM2 ARHA PMC7508753__F2 Contribution of the embryo, fetus, and trophoblasts to the programming of immune adaptations during pregnancy HLA-E HLA-G CXCL6 CXCL3 CXCL2 CXCL12 PMC12185286__F2 Mechanism of BMSCs transplantation on neural plasticity CNTF NGF GDNF TNF BDNF PMC2785342__F8 A proposed model for HA-CD44-mediated PKCE activation and Nanog signaling in the regulation of miRNA-21 production, oncogenesis, and chemoresistance in breast tumor cells DROSHA CD44 PMC3219211__F1 Small-molecule inhibitors in the ubiquitin–proteasome system (UPS) USP14 USP9X DDB1 NAE1 PMC10784739__F7 TIFA regulating the inflammatory and osteoclast differentiation in the RAW264 NLRP3 NFATC1 MMP9 PMC5671979__F6 miRNA-mRNA network ASF1B FBN2 PDE1B LEFTY1 TDG SLAIN2 ANKRD13C AK2 ZFAND3 WDR44 SMARCA4 OLIG3 MNT ATXN1 LIMCH1 RC3H2 TBX1 UNC45A CLIP4 RELL1 ZBTB44 IQSEC2 CROT OSTM1 CC2D1A IRF2 MAP3K1 KIF26B FOS TSLP NRK EDC3 TRPC7 PAN3 NUFIP2 CDC6 PTPRU GNAI3 ADAM10 GOLT1A HEL113 TOX PBX3 P2RX4 CLASP2 ULK1 PDE3A CTCF RFX1 POLG DHX15 PFKM LHX8 ASF1A PAPOLA TSHZ3 TIA1 SCHIP1 YWHAG MAFG TIAL1 LAMP2 DBT SBDS MINK1 LRP4 PMAIP1 AAG1 CRTC2 DOCK2 VPS37B NPAS2 PMC12055541__F4 Inflammatory Mechanisms Following SCI: In the acute injury phase: SCI directly causes vascular damage or severing, increasing the permeability of blood vessels CXCL10 GDNF CXCL2 CCL2 BDNF PMC12055541__F5 Molecular Mechanisms of Hydrogel in Improving the Microenvironment of SCI NLRP3 GPX4 TLR4 IGF1 KEAP1 MYD88 CSA2 BDNF ARG1 NQO1 STAT3 BAX PMC9683337__F2 Receptor activator of nuclear factorKB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds AIP CTSK KEAP1 GCLC NFATC1 HEL-S-8a OSCAR TRAF6 PMC4406847__F4 ROS are important contributor to renal injury and inflammation NLRP3 TXNIP IL1B PMC5962651__F2 Schematic presentation of autophagy pathway and core autophagy-related proteins targeted by various miRNAs ULK1 STX7 ATG12 ATG3 LAMP2 AMBRA1 ULK2 ATG10 DKFZp686F0183 WIPI1 VAMP3 WIPI2 UVRAG ATG14 PMC4309185__F2 Imd pathway in the fruit fly and the TNF pathway in the mouse TRADD TNF MAP3K7IP1 TRAF2 PMC6726749__F10 Based on our findings, there are several crucial paths, including PI3/AKT/mTOR as well as HIF-1A activation (in hypoxia) and inhibition (in normoxia) PI3 PTEN HIF3A MTOR TSGA10 PMC4309185__F3 The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in the fruit fly and the mouse COX2 JAK1 MCL1 STAT3 PMC5640164__F2 Metabolic regulation of the immune humoral response IL21R BAD BCR GC MDM2 CD40 CD80 PTEN RHEB ICOS CD19 PMC4309185__F1 Toll pathway in the fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse CD14 TLR4 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 MAL PMC3913901__F2 cIAP1/2 regulation of TNFAlpha-induced canonical NFKB pathway activation and suppression of default death pathways CAP2 CAP1 TRADD RELA TRAF2 CASP8 FADD MLKL PMC3913901__F3 cIAP1/2 regulation of TWEAK-induced non-canonical NFKB pathway activation TRAF3 RELB TRAF2 PMC11784353__F10 Schematic diagrams illustrate how EIAV negatively regulates RLR pathway activation by degrading MAVS TBK1 IRF3 SMURF1 MAVS PMC9284893__F7 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface PPP3CA MAP3K11 TGFBR1 RASA2 NRAS TGFBR2 TRAF6 FLNB MAPK8IP2 CRKL TAOK1 FGF9 CACNG4 FGFR1 RAPGEF2 FGF7 DUSP4 MAP3K1 PPP5C PDGFRA SOS2 FOS FGF2 MAP3K5 CACNB3 CRK HEL-S-31 CACNG8 NLK IKBKB MAP4K2 MAP2K1 STK4 DUSP16 RAF1 RPS6KA6 AKT3 PMC9284893__F8 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface CD14 EGF FLNA TRAF6 CDC25B MYD88 TNF MAP3K7IP1 NLK MAX GRB2 JUND ECSIT RAF1 TRAF2 MEF2C CDC42 PMC11665378__F5 Schematic view of the relationship between ncRNAs and the LC cell progression, invasion, and migration via the PI3K signaling pathway EGFR PTEN NQO1 PMC11665378__F6 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications EGFR PTEN CDH2 XB IRS1 PMC5372827__F6 Strategies of enhancement of folate level in plants GGH DHFR FPGS DHPS PMC11665378__F3 This schematic illustrates the downstream pathways influenced by AKT activation TSC2 BAD GSK3B MDM2 GIP MTOR RHEB PMC9382085__F8 Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NFKB/STAT3 pathway in mice as revealed by network pharmacology study MMP9 STAT3 BAX PMC11665378__F4 Schematic view of the relationship between ncRNAs and LC cell proliferation and apoptosis via the PI3K signaling pathway NOVA2 METTL3 NOTCH1 CDK4 PTEN CDK6 CCNE1 BAX PMC8072393__F2 Autophagic Organelles in DNA Damage Response ATG12 ATF4 EIF2A UVRAG ATG14 XBP1 DKFZp686F0183 PMC11665378__F1 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications PIK3CD RICTOR PTEN MTOR MLST8 PMC9339672__F1 Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease GPR32 GPR18 PMC8035741__F5 Graphical representation of the potential apoptotic pathway induced by the Human-RPSA siRNA in late (DLD-1) stage colorectal cancer cell ATM POP1 H2AX BNIP1 BAX PMC6421413__F8 Protein associations and potential functions of SHARPIN in human megakaryocytes and platelets CYLD RELA SHARPIN CD40 OTULIN PMC7193283__F5 Mechanism of RES on improving NAFLD LOXL2 IL16 TLR4 PLIN1 CIDEC NR1C1 SIRT1 STAT3 CD36 PMC7193283__F3 Mechanism of TSG on improving NAFLD ABCG5 TG NR1C1 CYP2E1 CYP7A1 PMC8374068__F3 Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan IGF1 MTOR IRS1 BAX PMC7193283__F4 Mechanism of emodin on improving NAFLD TLR4 ATF4 SMAD2 EIF2A MTOR TG PMC9409738__F5 Comprehensive Review on the Anti-Cancer Effects of Oleuropein TFEB EGFR MTOR FASN PMC2928307__F1 Plastids play a central role in the generation of wounding and herbivory induced signals GLA PMC11544107__F5 Aripiprazole-target-disease-pathway network and molecular docking results of aripiprazole with core targets HTR1B ALB IRAK4 DRD1 DRD2 DRD4 GRM2 CSF1R FYN FGFR1 CHRM2 ABCB1 HTR1E OPRD1 ADRB1 HTR7 ADRB2 TNF SSTR2 DRD3 RET SLC6A3 GALR3 CHRM1 HTR1A SGPL1 OPRK1 ADRA1A HTR2A HTR6 NR3A2 ACHE RIPK2 SLC22A1 HRH1 DRD5 NR2F2 BTK ABCG2 KDM4B HRH2 OPRM1 ADRA2C TACR2 EGLN1 HCN4 ADRA1B CHRM3 CYP3A4 AK3 ABCC1 LYN HCN1 ADRA2B HTR1D PMC8985313__F8 Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling STAT1 ANXA1 FPR1 FPR2 STAT3 PMC11544107__F4 Distribution of key targets in the two main pathways HEL-S-62p CORT GHB3 APELA DAO APLN PROC GIP CALCR LPA GALR1 BRS3 THRA MLN POMC NPY GHR KNG1 GAL ADM NPSR1 ABRA PBR SELE HCRT NPB SCT GIPR PMCH NTS PTH SCTR GHRH SPR CTSG NMU CCK LEP EDNRA CRH NPS CYC1 AVP SPX OXT FSHR LHCGR NPFF PMC7328045__F1 Proposed inhibition of SARS-CoV-2 entry/replication by intervention at the NPC1 pathway NPC1 ACE2 TMPRSS2 PMC8841848__F3 Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 TRIM25 PMC7759481__F1 Induction of IFNs and the antiviral state they exhibit in bat (P TBK1 STAT2 IRF7 ATF2 TRAF3 IRF3 MYD88 RNASEL STAT1 ISG15 RNASE1 OAS1 TYK2 JAK1 JUN MAVS PMC2677440__F7 Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway AREG MUC5AC EGFR TGFA TLR3 PMC11743330__F2 MiR‐30a‐5p inhibiting the Wnt/B‐catenin signaling pathway APC LRP5 LRP6 PMC4796280__F2 Store-dependent and -independent Ca2+ entry pathways in smooth muscle LTC4S EIF4E ORAI3 MTOR ORAI1 STIM1 PMC6826537__F1 Pathways controlling the epithelial-mesenchymal transition (EMT) program in prostate cancer (PC) SMAD2 FAP GSK3B CDH2 HES1 HES2 PMC3900298__F5 New immunological approaches in treating and diagnosing CNS diseases GLI3 SHH TRPV1 PMC4747375__F7 Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma AREG EGFR PMC5532623__F2 MET regulated signaling pathways implicated in the hallmarks of cancer HGF SRC CRK STAT3 PMC3647962__F13 TNFA signaling pathways to IKK activation TH TRADD TRAF2 PMC8706409__F10 Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage IKBKB RAF1 TNF GATA4 STAT3 PMC2949127__F3 HMGB1 signaling events mediated by RAGE and TLR2/4 and therapeutic strategies for cerebral ischemia HMGB1 TLR4 TRAF6 RAC1 MYD88 CDC42 PMC9410782__F1 Advances in Research on the Molecular Function and Specific Role of Circular RNA in Cardiovascular Diseases PINK1 QK3 LRP6 ARC MYD88 HMOX1 SIRT1 FOXO1 AKT3 PMC6734673__F2 Epidermal growth factor receptor Pathway and its two pathways: Ras/Raf/Mitogen-activated protein kinases or PI3K/AKT EGFR GRB2 PTEN MTOR PMC5698505__F3 mTOR signaling TSC2 PTEN HIF1A RHEB PMC6559821__F3 Main signaling involved in non-canonical pathways regulating HIF-1/2 VHL PTEN RPS6 MTOR PMC6147171__F3 Mechanisms contributing to the repression of hepatic gluconeogenesis by Wnt signaling activation PCK1 TCF7L2 CRTC2 PMC9359802__F4 Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines RNASEL TLR3 MAVS PMC5628821__F6 Design and validation of a 90K SNP genotyping assay for the water buffalo (Bubalus bubalis) MLIP PML TMEM87B SYT13 SMIM7 GDAP2 C5orf34 MRM1 DHX35 TMEM208 ZNF701 SLC26A11 ZNF586 LMNA ZNF222 PURG RNF44 SLC7A6OS ORMDL2 HNF4A TINAG NRXN1 ME3 P3H2 PMC6147171__F1 A) A simplified schematic of the Wnt signaling pathway APC LRP5 INS LRP6 PMC9332329__F2 Interactions between phages and immune system components are varied and complex TH TLR9 IL13 F3 MYD88 TLR1 AIM2 TLR3 PMC6135464__F5 Pathway visualisation SI TES PMC3190874__F2 FcERI signaling pathway is negatively regulated by a number of cell surface and intracellular proteins that act at various points in the FcERI signaling network BTK FYN TLR4 CSK LYN SYK LAT PMC9263675__F4 Update on the pathogenesis of vitiligo STAT1 CXCR3 CXCL10 CXCL9 IL15RA JAK3 JAK1 IFNG PMC3190874__F1 Immunoglobulin E Receptor Signaling and Asthma BTK FYN LYN SYK MTOR LAT PMC4884112__F8 Proposed crosstalk between EGFR signaling pathway and Hippo pathway in the diabetic kidney AREG SMAD2 EGFR HBEGF LATS1 PMC9949365__F1 Orthogonal Functional Genomic and Proteomic Analyses Nominate AKT Activation as an Actionable Consequence of Selinexor Treatment KY PLK1 GSK3B PTEN MTOR DEPTOR PDPK1 MAPKAP1 TSC2 PIK3R5 RICTOR TSC1 FADD AKT3 PMC9015684__F1 Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants EGF EGFR SRC PTEN PMC8458546__F3 Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement ITGA1 NOSTRIN RASD2 GUCY1A2 ADCY1 MMP9 VEGFA PLCG2 RALB RAP2A LPAR4 ANGPT1 NR2F2 CASP3 CHRNE NRP1 GRB2 NOTCH1 NOSIP ITGAV PLA2G2A CASP8 PROK1 PMC9479335__F5 Case report of the sustained and rapid response of bevacizumab in a TP53-positive breast cancer and liver metastatic patient through personalized medicine MDM2 PTEN MTOR PMC7086291__F2 Leukocyte extravasation signaling ITGAM ITGB4 MMP9 JAM3 ITGB1 JAM2 PMC7086291__F3 Tec kinase signaling TEC SRC PMC7086291__F4 Osteoarthritis signaling ADAMTS4 TLR4 ELF3 WNT16 IL8RB COL2A1 NOS2 SP7 SMAD1 FRZB PMC6618585__F2 Tumorigenic mechanisms of Fusobacterium nucleatum in colorectal cancer TLR4 BIRC3 TIGIT MYD88 PMC7139528__F6 Nervous system interaction effects of the KEGG enrichment pathway terms and putative target proteins identified in A CHRNA7 GNB5 ALOX12 MAOA DRD1 ACHE DRD2 PTGS1 CACNA1C DRD5 PRKCA GRM2 FYN APP MAPK1 GNAL CHRM2 ARAF CALY FOS HRAS HTR4 CREB3 PLCB1 CASP3 DRD3 TRPC1 MAP2K1 PLA2G4B CHRM1 HTR1A BCL2 GNAS AKT3 PMC8226978__F1 Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management BAD GC BCL2 PTEN STAT3 PMC6892284__F1 Number of studies suggest that an increase in microbial BSH activity results in a reduction in stimulation of intestinal FXR ABCG8 ABCG5 FGF19 CYP7A1 PMC9200584__F3 Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis EGF CHUK COL3A1 EGFR MAPK3 MYC MAPK14 CXCL8 BCL2L1 CCL2 HMOX1 IFNG NLRP3 MMP3 PRKCA KDR opn CASP9 NOS2 JUN SELE CXCL11 FOS PTGS2 MMP9 CXCL10 VEGFA CXCL2 TNF IKBKB CASP3 NFKBIA RELA BCL2 MCL1 PMC5394985__F1 Interluekin-17A (IL17A) RORC CXCL1 IL16 CXCL8 CCL2 RORA STAT3 PMC11252768__F8 Working summary of the study SUFU SMO HMGCR PMC6496424__F1 Multiple mechanisms involved in the protective roles of NLRP6 in intestinal epithelial cells CCR5 IL18 NLRP6 IL22 CCL5 IL6 MYD88 MUC2 PMC7186417__F5 Pro- and anti-fibrogenic effects of LPS on activated HSCs IL10 IL16 TLR4 IL17A IL22 SMAD4 STAT3 PMC4873813__F2 Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism SOCS3 PC INS IL6 MTOR IRS1 INSR STAT3 CD36 PMC8069635__F3 Immune response pathway of SARS-CoV-2 ACE2 TMPRSS2 PMC2099483__F1 Circadian oscillation in leptin signaling pathway in mouse brown fat LEP SOCS3 LEPR STAT3 PMC8342764__F3 Cerebral Autoregulation in Subarachnoid Hemorrhage SPHK1 TNF CFTR PMC9441491__F7 Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis FGFR1 HIF1A MTOR IRS1 HEL-S-133P HK2 STAT3 PMC5821995__F3 Macrophage polarization in type 2 diabetes IL16 ATM PKNOX1 CCND1 IL1B CCND2 PMC8115150__F8 Schematic model describing the protective effect of Mzb1 in AMI. Injury of cardiomyocytes led to apoptosis and mitochondrial dysfunction, ROS release, and increased inflammation TNF BAX PMC1526596__F1 P38 mitogen-activated protein kinase (MAPK) signaling cascade in T cells GADD45B ZAP70 GADD45A PMC6770807__F6 Proposed action mechanism of 6SL PCNA CDK6 PMC5893867__F1 Fasciola hepatica modulates macrophage activation NLRP3 CD14 TLR4 PRX TLR3 PMC6561619__F10 Model of the molecular mechanisms involved in LRRK2 gene silencing in proliferation, migration, and apoptosis in TC cells LRRK2 CDK4 BAX PMC8863805__F1 An enhanced triple fluorescence flow-cytometry-based assay shows differential activation of the Notch signaling pathway by human papillomavirus E6 proteins MAML1 ADAM10 HES1 PMC3600829__F4 Functional analysis of the gene expression networks, performed using Ingenuity Pathway Analysis (IPA) KCNA3 LCN2 STAT5B CR1 SIGLEC5 ORM1 NEDD4 RNF125 IFNG CD163 TIFA FLT3 TGFBR3 GRB10 IRAK3 IL2RB PMC3350083__F1 Overlap in FcERI, FcGRIII, and FcGRIIB signaling FYN CSK LYN SYK TGFB1 PMC2936296__F2 RIG-I signalling pathway MAF TH ATG12 RELA RALA MAVS PMC7961611__F1 Transsulfuration pathway (TSP) and related pathways HEL-S-61p HEL-S-182mP HPD PMC2652403__F1 Signalling through the phosphatidylinositol 3-kinase (PI3K) affects cell growth, apoptosis and cell cycle regulation TSC2 BAD TSC1 MDM2 PTEN MTOR RHEB PMC7961611__F2 Hydrogen sulfide production pathways PMC6107379__F1 RAS/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) NF1 CS BRAF GRB2 SPRED1 SHOC2 SOS1 CBL PMC4076960__F8 Muscle hypertrophy and atrophy IGF1R HGF PPP3CA MAPK8 NFATC1 FGF2 GSK3B MAPK14 MYF6 MSTN EIF4E MTOR RPTOR CALM1 FST IGF1 ACVR2B MYF5 CDKN1A TRIM63 FBXO32 MAPK1 MYOG MYOD1 PMC9152764__F1 High Intensity Interval Training: A Potential Method for Treating Sarcopenia EEF2 EIF4E RPS6 EIF4B TFAM SIRT1 RHEB PMC11940482__F5 Calcium signaling pathway with RMPs PLN PI3 TFEB BCR CAV3 HEL-S-11 HRC MCU CAV2 TRDN PMC6050811__F1 The cyclin D1–CDK4/6–RB pathway in breast cancer.The role of the cyclin D1–CDK4/6-RB pathway in breast cancer cells, including cross talk with other oncogenic signaling pathways TSC2 EGFR CCND1 CDK4 MTOR CDK6 PMC7594502__F2 Mitophagy pathways in health and disease TBK1 NLRX1 FUNDC1 BNIP3 OPTN PHB2 PMC6289780__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes IDI2 IDI1 IPP GGPS1 PMC9373848__F1 Autophagy in Adrenal Tumors ATG12 EEA1 AMBRA1 DKFZp686F0183 PMC11814419__F6 Schematic for the mechanism by which PGAM1 functions to promote the malignant phenotypes of BC via the Wnt/Beta-Catenin signaling pathway APC GSK3B PGAM1 PMC2923738__F4 Human erythrocyte metabolism modeled using detailed enzyme rate equations KIN GRAP HEL-S-162eP PMC9598206__F7 GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis GPX4 LPCAT3 FACL4 PMC3249418__F3 Migration of marginal zone precursor B cells regulated by type I interferon (IFN) and IL-17 CXCL13 PDC CXCR5 CD69 PMC5054603__F3 Gene expression changes in neurotransmitter signaling pathways PLCL1 MAPK9 GNB2 MAPK8 ATF2 MAPK3 GSK3B GNG7 DRD4 KIF5A CACNA1A FYN MAPK1 GABRA2 FOS ADCY1 MAPK10 GNGT2 GABRB2 GRIA2 PIK3R3 GABRP CHRNA6 GNG3 GNG8 GABRA4 GABRG3 PLCB2 PIK3R5 GNA11 DRD3 HEL-S-80p MAPK13 GABBR2 GABRE GNAI3 ADCY6 BCL2 GABRQ GNAO1 GABRG1 GNB1 AKT3 GNB4 GNG13 GNB5 PPP2R1A GNG10 GNGT1 GNAI1 HAP1 GNG4 GNB3 GABRB3 TRAK2 GNG2 KCNJ6 GNG11 GNAL GPHN GABARAP GNG5 GSK3A GNG12 PPP2R5E GABRA6 CAMK2A GABRA3 PMC5877574__F2 The signaling pathways in response to DNA damage and key effectors that interact with ER signaling ATM MDM2 CDK4 CDC2 ATR PMC6826993__F2 After co-culture between adipocytes and breast cancer (BC) cells, high levels of miR-144 and miR-126 were released by exosomes by BC cells LEP RETN SRC TNF MTOR IRS1 SOX9 STAT3 PLOD2 PMC5054603__F4 Gene expression changes in the elements of postsynaptic signaling cascades GNB2 GNG7 GNG10 AKAP5 GNGT1 GRIK3 GNAI1 PDPK1 PRKCA GABRB3 GRIN1 GNG2 PICK1 MAPK1 GNAL CHRNG GNG5 NCALD GRIA3 GNGT2 GNG8 GNG12 PLCB2 CHRNE GABBR2 PRKCB AP2S1 GNAI3 GRIA4 RAF1 PMC8573439__F1 Mechanisms and pharmacological applications of ferroptosis: a narrative review HEL-S-102 GPX4 LPCAT3 STEAP3 KEAP1 SLC7A1 IREB2 SLC3A2 IPP DKFZp686F0183 TF PMC11803289__F2 How S1P works S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 PMC7073561__F1 Lipid biosynthesis UGCG SMS FASN PMC3075710__F3 Regulated fatty acid synthesis and metabolism during cell differentiation ACSL5 FACL4 C6 FABP5 TG HEL-S-104 PCNA CERS2 PMC6495170__F2 Ceramide metabolism CERS3 LASS1 DES CERS5 SMS CERS2 CERS6 PMC9334647__F2 Caveolin-1 in Sepsis – A Mini-Review VEGFA RAC1 PMC2670612__F2 Tumor resistance to EGFR-targeted therapies EGFR GRB2 PTEN RALBP1 PMC5259950__F6 Canonical Rho signaling pathways were identified in a phosphoproteomics screen of HIV-1 signaling via CD4 and CCR5 CD14 EGF F2R FLNA BAIAP2 APC ARHA DOCK1 FGD1 CRK GNG12 GRB2 LBP HEL114 PXN TRIO CDC42 PMC3199279__F2 Metabolic interactions between folates and vitamins B12, B6, and B2 HEL-S-61p DHFR PMC7773902__F2 Summary of the different therapeutics applied in aGVHD treatment HEL-S-171mP APC MSC CTLA4 PMC5841936__F2 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling FYN CD1D CSK LCK PMC5215107__F3 Genetic and Developmental Basis of Cardiovascular Malformations BMP2 SMAD2 SMAD4 TBR1 SMAD1 TGFB1 DKFZp781O1323 BMP4 PMC5841936__F3 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling CSK IL2 ELL IFNG PMC6697739__F6 An illustration of the bidirectional interaction between Th17 and BEC AHR CCR6 CCL20 TNF IFNG STAT3 PMC7523953__F4 Comparative transcriptome analysis reveals candidate genes related to cadmium accumulation and tolerance in two almond mushroom (Agaricus brasiliensis) strains with contrasting cadmium tolerance RER1 HP UGDH ACLY HEL-S-32 PMC3900785__F1 The metabolic pathway of homocysteine PMC5578024__F8 Differentially expressed genes associated with the cell cycle were annotated by KEGG E2F4 CDK2 SMC3 MDM2 SMAD4 DBF4 CDK7 PCNA ORC2 SKP2 MYT1 PMC10754983__F7 Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction ULK1 PTEN MTOR PMC3868899__F8 Nicotine’s effect on immunity via the A4 nAChR signaling pathway in T cells GPRIN1 CDC42 PMC4197746__F2 mTOR controls metabolism ULK1 IGF2 CAD ATG14 MLST8 PMC5503208__F2 Molecular mechanisms of dietary fat absorption within enterocytes ACSL5 ADFP LPCAT2 ACSL3 CIDEB PMC4197746__F1 Upstream of mTOR: classical and non-classical inputs ULK1 APC GSK3B LRP5 TBC1D7 LRP6 PTEN RAC1 MTOR IRS1 RHEB MLST8 TSC2 RICTOR TSC1 GRB10 PMC11251740__F1 Clinically relevant dysregulated pathways in GBM NF1 PDGFRA EGFR MDM2 CDK4 PTEN MTOR CDKN2A CDK6 PMC7295046__F9 Schematic illustration showing the proposed mechanism by which FABP5 promotes LNM of CCa by regulating FA metabolism VEGFC TWIST1 MMP9 FABP5 FASN PMC4340667__F4 Targeting mitochondria metabolism for cancer therapy HEL-S-44 MTHFD1 MTHFD2 PMC5362638__F2 MyomiR interaction with Akt-mTORC1 signaling pathway EIF4E RPS6 IRS1 PMC3414811__F2 Two branches of the unfolded protein response ATF4 EIF2A BCL2 TRAF2 XBP1 PMC3414811__F3 The mechanism of SLS TBP EIF2A SEC63 PMC8124393__F2 Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises GSK3B LRP5 LRP6 PTEN MTOR PMC7081367__F3 Disorders Caused by Genetic Mosaicism NF1 PTEN MTOR PMC9407616__F9 Transcriptome Analysis Identifies Key Metabolic Changes in the Brain of Takifugu rubripes in Response to Chronic Hypoxia HMGB1 PLPP2 HEL-S-30 HADHB PFKFB4 HEL-S-87p PDE1A PLCB1 HEL-S-61p PRXL2B CD59 NPY ENO2 AMPH ABLIM3 PMC8946740__F10 Proposed model of ARF-IFNB pathway STAT1 STAT2 IRF9 IFNAR2 MSTN IFNAR1 BCL6 PMC3478592__F1 Model depicts the development of conventional vs ITK IRF4 PMC4715152__F1 TRAF2 signal pathway networks TRADD TRAF3 CD40 TNF TRAF2 LTBR PMC4715152__F3 WWOX/WOX1 and signaling networks ERBB4 HGF RUNX2 HYAL2 WWOX PMC7718394__F5 Simplified diagram illustrating altered innate signaling following BCG treatment of HU and HEU monocytes TNLG1B CXCL1 TNFAIP6 IL23A PTGS2 CCL7 CXCL2 MYD88 CSF2 CCL3 PMC4695002__F6 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation EGR1 NCOR1 NFIB MYC CREB1 FBXL7 VMP1 SMARCC1 EGR4 RAD54B ECT2 RBMS3 TFAP2A MSH2 SP1 STAT3 PMC4736761__F4 Changes in genes associated with epithelial-to-mesenchymal transition after radiation HEL-S-62p ZBTB7A EPCAM NRAS JAG2 TRIB3 TRAF6 BMI1 MMP3 GDF15 MTSS1 TIMP3 FAP STC2 XDH CDH2 CSF2 KLF6 ZFPM1 TRIR FASN CSPG4 BMP6 SET PLAUR LIF MMP9 VCAN LCN2 PTGES ADRB2 IL6 HRAS HAS2 ID3 RICTOR TNS4 TGFA MME PMC5426651__F13 Mechanism of GnRH-(1–5) action in Ishikawa cells EGF GPR101 EGFR PMC4736761__F3 Cellular processes common to all nine cancer stem cell- (CSC-) associated genes CD133 SOX2 EGFR CD44 NOTCH1 BMI1 PMC7226484__F2 L-cysteine metabolism CTH SUOX PMC4695002__F2 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation CD133 NOC4L DSG2 MCRS1 SYNC SRC BAG6 MTOR RPTOR LAMC2 STAT3 IRF6 PMC1195384__F2 Folate pathway in Plasmodium falciparum and the proposed mode of action of the diaminopteridines, analogs of folate precursors DHFR DAP FPGS DHPS PMC3943663__F1 Dendritic cells in progression and pathology of HIV infection CCR5 CXCR4 TRIM5 PMC89003__F2 IFN signaling by the Jak-Stat pathway STAT1 TYK2 IFNAR2 JAK1 IFNGR1 PMC8616143__F1 Unfolded Protein Response as a Guardian of the Secretory Pathway ATF4 EIF2A XBP1 PMC11311379__F9 Regulatory effects of novel-m0230-3p on cell TJs and adhesion via CSF1/CSF1R/Ras signaling pathway in yak SCs CSF1R CSF1 PMC5119498__F1 Factors Implicated in Insulin/Growth Factor-Induced Regulation of Mammalian or Mechanistic Target of Rapamycin (mTOR) Complex-1 (mTORC1) TSC2 ULK1 TSC1 TFEB MTOR RHEB MLST8 PMC5228376__F3 Cytokine-cytokine receptor interaction of secreted cytokines EGF CCR3 HGF FLT4 EGFR CCL7 CCL16 CCR1 CSF1R FLT1 KDR CCL14 CCL24 CCL13 KITLG CCL8 KIT CCL11 CCL26 VEGFA CCL4 FLT3LG CCL15 FLT3 CCL23 CSF1 VEGFB CCL3 PMC6083487__F4 Cyclins and cell cycle regulation is the top pathway downregulated by citalopram treatment PTS ATR MYT1 PMC6463920__F6 Microgravity regulates cell proliferation and cell cycle via the CD117-Ras/cAMP-CREB pathway MAP2K1 E2F2 ATF4 CCND1 CDC2 DUSP2 CCND3 CCND2 PMC5866782__F2 Free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines CDH2 PMC3389589__F1 Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target TSC2 PTEN EIF4E MTOR RHEB PMC3580761__F2 Regulation network of CYP3A4 phenotype expression adapted from Klein et al USF1 EBP IL1RN IL6 POR PGRMC1 IL6R NR1C1 RXRA ALAS1 RARA SLCO1B1 PGRMC2 NR1i1 SLCO2B1 FOXA3 IL6ST PMC1857250__F2 Tregs and rethinking cancer immunotherapy CTLA4 FOXP3 PMC5064863__F5 Endocrine related Hippo Signaling Pathway AFP SOX2 AMOT AREG BIRC5 APC MYC SCRIB LATS1 ID1 LATS2 NKD1 BIRC2 PATJ GIG8 AMH PALS1 AXIN2 RASSF6 PMC4855716__F6 miRNA-gene network in the steroid hormone biosynthesis pathway and regulatory network in early sex differentiation of Nile tilapia AMH DMRT1 CYP11B2 PMC9443660__F5A Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis ADAR COMP ACE2 tal-1 GLA PMC4000931__F3 Summary of the miRNAs and the VEGF pathway involved in HSCs CASP9 SPRED1 CCND1 PMC12084487__F2 Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies RIPK1 RIPK3 FADD ZBP1 MLKL PMC12084487__F3 In the mTOR signaling pathway, PI3 K/AKT/mTOR axis can induce the occurrence of apoptosis TTI1 ULK1 RIPK1 GPX4 BAD SLC7A11 RIPK2 DEPTOR MLST8 BAX PMC7383642__F1 Reported coagulation pathway variations in African Americans PLG FDPS VWF PMC6100747__F3 Notch signaling pathway EGF PIN1 AEN DLL4 JAG2 MYC ADAM10 DLL3 HIF1A PMC6100747__F1 Ischemic stroke initiates cell death mechanisms in brain cells following an acute depletion of blood flow, resulting in the formation of an infarct core IL1B PMC7230881__F7 Summary of the cellular response to oxidative stress in CC4348 (A) and the gpx5 mutant (B) GPX1 HEL-S-75p HEL-75 PMC10758606__F1 NFKB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells RELA RELB CD40 PMC12056177__F7 Schematic description of kinase signaling pathways in Alzheimer’s disease BACE1 EEF2 ERBB3 GSK3B CDK5 CDC25B MTOR HDAC1 TTBK1 FYN ATM APP ADAM10 BDNF SIRT1 STAT3 BAX PMC12056177__F8 Schematic description of kinase signaling pathways in Parkinson’s disease PINK1 LRRK2 AIMP2 FKBP5 PARP1 PMC6040236__F7 Schematic for alternative complement pathway activity in fHm/m/fP−/− mice HEL-S-62p FH RPE PRL PMC12056177__F9 Schematic description of kinase signaling pathways in Huntington’s disease IGF1 HTT CDK5 MTOR BDNF PMC12056177__F6 MAP3K-MAP2K-MAPK signaling pathway MAP3K11 GRB2 PMC7037688__F2 NF-E2 p45-related factor 2 (NRF2) transcription pathway and evaluation of potential biomarkers in Friedreich’s ataxia GPX4 FXN HEL-S-112 NCF2 PMC6100747__F5 Following stroke, the stability of NICD is increased by its interaction with Pin1, and the NICD-Pin1 complex then translocates to the nucleus PIN1 AEN VHL HIF1A PMC4995965__F4 DVL phosphorylation by NEK2 affects Wnt signaling NEK2 INS PMC10380727__F2 Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect SMAD2 TRPC6 C6 PMC6810715__F2 Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin MAP2 MAP2K4 RUNX2 NODAL SMAD2 SMAD4 TRAF6 MAP4K1 AMH NR1i1 TLX2 NKX2-5 ZNF423 GSC RNF111 SKI JUN IRF7 PITX2 FOS MAP3K7 SMAD6 BMP7 SMURF1 MAP3K7IP1 HDAC1 HOXC9 HNF4A MAP2K1 SMURF2 GRB2 TGIF1 BCL2 TMEPAI RAF1 SMAD1 TGFB1 DKFZp781O1323 CDC42 FOXH1 PMC7991106__F1 Process of glycometabolism in ECs HEL-S-30 F2 FOXO1 HK2 PMC2897145__F7 Molecularly and temporally separable lineages comprise the hindbrain roof plate and contribute differentially to the choroid plexus gdf7 LAT CP PMC7248369__F7 Integration of transcriptomic and metabolomic data NEIL2 ADCY1 SLC6A19 MYC RB1 GAA GPX3 HAAO HPGD CNR2 LAP3 BCAT1 RRM2 HEL-S-2 TYMS PAICS SLC16A2 CGN FASN PMC7867633__F4 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes ULK1 IGF1 PRLR POLL PTEN EIF4E PRL SMN1 POLI PMC4301186__F1 Interplay between lifespan regulation and brain function FOXO6 MTOR SIRT1 PMC3010981__F1 Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells MUC5AC MUC5B PMC7867633__F1 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes NRF1 POLL POLRMT TFAM POLI PMC6768965__F1 Manipulation of the interferon signaling pathway in myeloid cells TBK1 CGAS CPSF6 TRAF3 TREX1 DDX41 IRF3 IRF-1 MAVS PMC7867633__F3 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes EGFR GRB2 POLL SP1 SOS1 POLI PMC7246472__F2 Activators and inhibitors of Wnt/Beta-catenin signaling pathway HMGB1 PTH1R RUNX2 BMP2 MSX2 SFRP5 SIRT1 PMC6959606__F4 Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector HEL-S-1a PMC12240186__F1 Mechanistic basis of XPO1 dependency SOX2 HDAC7 MYC RB1 PMC3554769__F1 Mathematical Model for MicroRNA in Lung Cancer HMGA2 MYC PMC8531217__F6 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development SQLE CYP46A1 DHCR7 EBP SC5D DHCR24 HSD17B7 TM7SF2 CYP51A1 PMC3958036__F9 Schematic model of how SH2B1B enhances gene expression and neuronal differentiation through STAT3 (step 1) EGR1 FGFR1 SH2B1 CDH2 STAT3 PMC8000236__F6 Top predictive features for not mutated IGHV CLL patients CXCR1 IGF1 TP63 NR1C1 CDC42 PMC8531217__F1 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development SQLE HMGCR PMC7348140__F6 LncRNA NR2F1‐AS1 promoting breast cancer angiogenesis through IGF‐1/IGF‐1R/ERK pathway via sponging miRNA‐338‐3p IGF1R IGF1 PMC4439933__F4 Detailed self-regulation scheme of cancer development in ERG+ well differentiated tumor samples RAP1A GRIP1 ERG FGF2 NRAS GRB2 BMP7 HIF1A HRAS BMP4 PMC8000236__F7 Top predictive features for IGHV-mutated CLL patients CXCR1 MTOR NR1C1 CDC42 PMC11936945__F1 TRAIL-DR5 related cell death regulation signaling pathway (Das et al AIP RIPK3 TNF TRPM7 GSDMD CASP3 NLRP3 ATM APAF1 CASP9 BCL2 ATR TRAF2 GSDMC CASP8 MLKL STAT3 BAX PMC4220672__F1 Novel strategy for the use of leptin for obesity therapy LEPR STAT3 PMC8062588__F2 Cancer stem cells and strategies for targeted drug delivery CD9 BAD NRF1 SOX2 EPCAM CD63 MYC BMI1 XBP1 BRCA1 TSG101 ATM ATF4 RAD50 RAD51 MCL1 ABCG2 EZH2 IL1B BAX PMC8997719__F6 Total and Mitochondrial Transcriptomic and Proteomic Insights into Regulation of Bioenergetic Processes for Shoot Fast-Growth Initiation in Moso Bamboo PDC CS OGDH DLAT MAL HEL-S-162eP PMC6335102__F10 Renal ion regulation in response to ANG II DCT WNK4 NHERF1 PMC5904535__F12 NF-Kb signaling pathway regulates cellular inflammatory, oxidative and apoptosis MPO PMC11360101__F13 Actin Dysregulation Mediates Nephrotoxicity of Cassiae Semen Aqueous Extracts ARHA RAC1 CDC42 PMC6335102__F13 ANG II signaling in aging TSC1 MTOR PMC8283198__F2 Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis PCSK9 VCAM1 LDLR PMC8265274__F3 F-Actin Dynamics in the Regulation of Endosomal Recycling and Immune Synapse Assembly RAB35 APC RAC1 RAB7L1 ARL13B VAMP3 STX16 CD80 ARL3 CCDC28B INF2 SNX4 UNC119 VAMP7 CDC42 IFT20 MAL PMC3334963__F7 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing TBK1 STAT1 BTK PIM1 IRF7 TRAF3 TRAF6 IRF3 IRAK4 MYD88 PMC3334963__F8 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing TRADD APIP CASP9 APP IRAK4 PTEN FAIM2 CIT TRAF2 GHITM PMC9234462__F1 Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity TBK1 TLR4 COCH PMC9240418__F6 Molecular checkpoints of distorted autophagy pathways in lupus nephritis PINK1 ULK1 ATG16L1 PARK2 ATG12 ATG3 ATG101 MTOR ATG14 DKFZp686F0183 PMC9227157__F3 Does Abiotic Host Stress Favour Dothideomycete-Induced Disease Development? FER SOS2 IMPACT SOS1 PMC8578927__F1 Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies XCL1 CCL5 IFNG PMC4280582__F4 Schematic representation of the HTRA2 protein and its activation against mitochondrial stress PINK1 CDK5 HTRA2 PMC4315929__F7 Cilia assembly and disassembly cycle PLK1 CEP97 DVL2 CEP290 PMC7847503__F7 Summarized molecular mechanisms of the signaling pathway involving the EGFR, TrkB, KRAS HIF-1A and VEGF-A genes; adapted from EGF ATF4 EGFR GRB2 VEGFA BDNF PMC6582778__F7 Proposed model of F IL10 ARG1 IFNG PMC4718713__F5 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications APC GSK3B BMI1 TNF PMC4718713__F6 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications RYBP APAF1 MDM2 RNF2 FADD BAX PMC2938100__F4 Connections of literature-completed interactome of PI3K-mTOR pathway with other signaling pathways IGF1 RHO MTOR PMC4043666__F7 Mass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention Relationships F2 F5 F3 PMC3177269__F4 Proposed model for a common symbiotic signaling pathway between actinorhizal plants and legumes NUP133 NUP85 PMC11958682__F2 Rewired amino acid metabolism and FA metabolism in HCC SLC38A11 BCAT2 SHMT1 OTC PHGDH SLC38A1 SLC7A5 GOT2 BCAT1 GPT2 PSAT1 ASNS ACSL1 PSPH CAD ACLY ARG1 ASS1 GLUD1 ASL CD36 PMC4718713__F4 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications RELA RELB SRC EZH2 PMC11958682__F3 Rewired acetyl-CoA metabolism and redox homeostasis in HCC HEL-S-64p SLC38A1 GLS PMC8024338__F8 MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis CCND1 CDK4 PMC3752952__F1 Pathomechanisms of LN outside the kidney FCGR2A IRAK1 C4A DKFZp686F0183 CR1 STAT1 TLR7 IKZF1 SIGIRR CRP PTTG1 CD19 TNLG2B TNF BLK PTPN22 ITGAM FCGR3A RASGRP3 BANK1 STAT4 CD22 LYN TREX1 TYRO3 CR2 TNFAIP3 DNASE1 PMC9127837__F5 Mitochondrial DNA Instability in Mammalian Cells FEN1 NEIL2 POLE NTHL1 RAD51 MUTYH OGG1 MRE11A DNA2 EXOG BRCA1 NEIL1 PMC1682009__F1 Activation of the Akt pathway through binding of a ligand to a receptor, tyrosine kinase TSC2 TSC1 EIF4E MTOR RHEB PMC3563611__F8 Candidate miRNAs target genes involved in cell growth, survival, migration, and cell cycle progression BAD HEL-S-28 CRAT PTEN CBL PREX2 PRMT1 CDK2 GRB2 BTG1 CDK4 BTG2 CDC42 PMC4072696__F9 Integrative Identification of Deregulated MiRNA/TF-Mediated Gene Regulatory Loops and Networks in Prostate Cancer CDK2 MDM2 GRB2 PTEN MTOR PMC9334593__F6 Pathway for glycine and serine biosynthesis in CC7-B01 response to heat stress HEL-S-61p HEL-S-182mP BAD PSPH PHGDH PMC4786553__F5 Top networks activated in the CPu during CIE and acute withdrawal PIK3R1 MAPK3 MYC MARK4 CASP2 CACNA2D1 RGS14 MEF2D SERPINC1 NTN1 GRM2 PLXND1 KDR SLC1A2 HTT GDNF MTDH B2M CASP8 SNCA HRAS GPX3 ARHG PPP1CC HOMER2 GRM3 DAGLA SLC1A3 BDNF SERPINF2 TENM2 CP CYCS PMC11187922__F9 The main findings in this study MGP MSC opn MDK PMC5793173__F2 Transcription complexes induced by physiological and aberrant Wnt pathway activation YAP1 APC TBX5 PMC6857109__F1 The E-cadherin (E-cad) interactions and signaling pathway ERBB2 ERBB3 APC EGFR CCND1 RAC1 BCL9 PMC8429807__F3 Smoking and the Pathophysiology of Peripheral Artery Disease NLRP3 MPO IL13 EIF2A SIRT1 SIRT3 PMC1860037__F1 Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies? SOCS3 GRB2 SOCS1 STAT3 PMC7606466__F6 RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGFB) signaling PML UCHL5 MAPK9 ROCK1 SMAD2 SMAD4 WWP1 ZEB2 SPTBN1 APP CCND1 SNW1 STRAP TGFBR3 LIMK2 ITGB3 YAP1 HDAC1 ITGB4 CDKN1A NEDD9 RAF1 SOS1 SHC1 MEF2C PMC9880437__F1 Pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine NLRP3 NLRC4 AIM2 IL1B GSDMD PMC11352994__F7 Schematic overview of the B7-H4-mediated signalling pathway in trophoblast cells in patients with early-onset PE CCND1 STAT3 PMC5793173__F3 Crosstalk between canonical and alternative Wnt signalling and the Hippo pathway YAP1 LRP5 LRP6 LATS1 RHO DKK1 MOB1A MOBKL1A LATS2 BMP4 PMC8150686__F1 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research FYN GRB2 PMC4541496__F7 SKN-1 regulation in the GSC longevity pathway KRI1 TFEB GSC NR1C1 PMC6213994__F6 Anti-oxidative signaling and anti-apoptosis signaling pathways KEAP1 BAX PMC8150686__F2 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research MTOR PMC8446626__F2 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis FOXC1 CXCR4 HIF1A MTOR PMC8446626__F3 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis FOXC1 EGF PIN1 NFKB1 RELA EGFR MTOR PMC4552638__F8 Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway TSC2 TSC1 EIF4E PMC7697769__F4A Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment ATF2 TRAF3 TRAF6 IRF3 TLR3 IFNG NFKBIB TLR4 TYK2 TRAF2 JUN IRF-1 TARBP2 TIRAP PMC4829114__F1 Metabolic pathway of P2Y12-receptor inhibitors IL1A ITGB3 ITGA2B PMC8958338__F10 Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications COX2 COX1 PMC8607308__F2 Infection with SARS-CoV-2 shows differential gene expression in Interleukin-6 signaling STAT1 SOCS3 PTPN11 TYK2 IL6ST IL6 JAK1 IL6R STAT3 CBL PMC10340792__F2 Targeting transcription factor YY1 for antitumor therapy EEF2K ERBB2 EGFR YY1 CD80 HSF1 PFKP PMC8762348__F5 NMNAT3 regulating NAD+ in BMSCs to improve mitochondrial function and inhibit cell stress-induced apoptosis SIRT3 PMC4075356__F6 An Irf6-dependent pathway regulating keratinocyte migration ARHGAP29 IRF6 PMC5362152__F7 Schematic representation of the proposed model EGFR PMC6214187__F1 SCAP/SREBPs Are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy ACACA ACACB EGFR GSK3B LDLR SIRT1 HMGCR PMC4259449__F5 Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways NUAK1 CELF1 VAMP2 NIPAL3 SETMAR TP73 TFRC WAS CDK7 MLKL COX7B2 PMC7902504__F1 Kinase pathways mediate dendritic morphogenesis and maturation SEPTIN7 ABL2 LIMK1 MARCKS CDK5 ARHA ABI2 MTOR TAOK1 SIK1 DYRK1A TAOK2 AAK1 BDNF PMC4632006__F1 Left: the PI3K/AKT/mTOR pathway is mainly activated by nutrients (not shown) and growth factors, binding to receptor tyrosine kinases and activating PI3K APC PTEN EIF4E MTOR DEPTOR RHEB TSC2 BMPR2 TSC1 ROR2 EIF4B SMAD1 DKFZp781O1323 PMC3025834__F1 Schematic representation of xylose metabolic pathway in metabolically engineered S XK XDH RPE PMC3634196__F7 Summary diagram of the proposed mechanisms underlying CA3 hypersensitivity, Alzheimer’s disease protein induction, neuronal death and behavioural deficits following cerebral ischaemia in rats with LTED BACE1 CA3 JUN PMC5403663__F2 Enrichment of gene expression changes (p < 0.05) shared by the TCF4 small interfering RNA (siRNA)#1 and TCF4 siRNA#2 conditions in the “cell cycle” KEGG pathway (p = 0.006, Bonferroni-corrected) CDC20 CDK2 SMC3 MDM2 SMAD4 CCL4 DBF4 RAD21 CDK7 PCNA SKP2 PMC3959159__F1 Major components of the TGF-ß signaling pathway SMAD2 SMAD4 UNK PMC8395387__F2 Pathophysiology of thrombosis in IBD TFPI PLG ADAMTS13 PF4 VWF TF PMC8124719__F9 Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells EGFR MDM2 SRC STAT3 BAX PMC8066561__F1 DNA double-strand break repair mechanisms and PARP inhibitor function CHEK2 PALB2 FANCD2 ATM BARD1 RAD50 SSB ATR CHEK1 MRE11A BRCA1 PMC5033717__F1 Dll4-Notch Signaling in Macrophage Activation NOTCH2 NOTCH4 RBPJ NOTCH1 NOTCH3 PMC6385460__F1 The AMPK/mTOR signaling pathway in TNBC tumor growth and progression ULK1 EGFR SRC MTOR STAT3 MLST8 PMC5442421__F1 Simplified scheme of ‘the metabolic map of cancer cell' PCK2 HEL-S-162eP PMC6605314__F10 Schematic model of GPCR-mediated gene expression in neurons DUSP5 EGR2 ARC BDNF CRTC1 PMC4102378__F2 WNT signaling pathway HEL-S-28 GSK3B MYC CCND1 SRC PMC4049637__F1 Functional Conservation of Coenzyme Q Biosynthetic Genes among Yeasts, Plants, and Humans COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PPT1 COQ7 PMC8604761__F1 Pyroptotic pathway in immune cells NLRP3 RIPK1 TNF IL1B GSDMD PMC7122831__F2 Terpene biosynthetic pathway in rose-scented geranium ME2 MVD MVK IPP PMC4029595__F7 Proposed breast cancer signaling pathway based on the KEGG network pathway analysis of hypoxia-activated tumor cell migration HEL114 CDC42 PMC10149994__F1 Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses STAT1 STAT2 IRF9 IRF3 MAVS PMC4227541__F2 CD40 stimulation stimulates a highly coordinated immune response by epithelial cells (ECs) NFKBIA NFKBIZ NFKBIE PMC9125181__F7 Endothelial Beta-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability PLVAP LRP5 LRP6 FZD4 PMC6702836__F6 Partial pathway reconstruction of genes involved in lipids, nucleotides and vitamins metabolism PC DAP PAH CP PMC8094936__F8 Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2 TANK TRAF3 TRAF6 IRF3 MAVS PMC9302637__F2 Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy BDNF GABRA4 STAT3 PMC7580701__F1 Effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2 IDO1 AHR ACE2 TMPRSS2 IFNG STAT3 FOXP3 PMC8478647__F2 External and internal signaling events on the surface of lysosomes NPC1 TFEB SLC38A9 ZKSCAN3 CASTOR1 SYT7 DEPTOR RHEB PMC11893431__F2 Molecular mechanism of SATB1 in breast cancer BRAF TWIST1 SATB1 MTOR PMC6682621__F2 Polyamine metabolic pathway with differential expression genes and reporter metabolites highlighted SMOX SRM SMS PMC5576761__F4 High activity of immune response CENPM CHAF1A PSMA4 NUP188 GINS3 MED31 CDC45 IFNG CXCL13 TNFSF6 MCM5 PSAT1 E2F2 GZMA SKA1 PRF1 ZWINT CCL3 PMC4231066__F6 Ethanol Negatively Regulates Hepatic Differentiation of hESC by Inhibition of the MAPK/ERK Signaling Pathway In Vitro FGF4 HGF CCND1 PMC6046302__F1 MAPK and PI3K/AKT/mTOR pathway interactions in melanocytic tumors GNA11 BRAF PTEN PMC2709380__F7 Hypothetical model of transcriptional regulation of the p21 gene and p53 pathway BCOR ZBTB2 SP1 PMC7254954__F7 PLAG-induced TXNIP and MMP-9 expression in breast cancer cells EGF EGFR TXNIP CBL PMC5701999__F3 Two arms of the insulin signaling pathway in skeletal muscle cells PAK1 VAMP2 STX4A RAC1 PMC9632296__F5 T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy CDA EGFR PMC11480210__F3 14-3-3 proteins in the TNFR signaling pathway TRADD TRAF1 TNF MTOR PPM1B TRAF2 BAX PMC11480210__F4 14-3-3 proteins in bone biology ACAN COL2A1 COMP PMC6281172__F2 IFN-JAK-STAT signaling pathway STAT1 MED14 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 BRD2 BRD4 PMC11480210__F2 14–3-3 proteins in MAPK, PI3K/AKT, TGFB/Smad, Wnt/Beta-Catenin and Hippo/YAP signaling pathway APC TNF JUN BAX PMC5780129__F7 Co-expression network constructed for the signature genes APOA4 CCDC121 TMEM161A NXPH4 PCK1 GPATCH2 RSRC1 GPSM3 CG018 KLHL24 MDFIC AMBP SHC3 BAAT BTF3 FCN2 TSG101 MED17 SOX3 PNMT INTS7 CTF1 THBS1 SEC61A1 SOX14 GPD1 NELL1 MMD ATXN3 RPL38 SCTR FUS ACSM3 LMO1 STK11 RNP24 CAPRIN1 PMC7097195__F2 Lysosomes as a therapeutic target TFEB OSTM1 PMC8036789__F4A Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs TRAK1 COX2 TLR4 NGF CX3CL1 CXCL12 PMC6089967__F2 Gene network of the susceptibility pathways/GO terms PLG CHRNB4 KCNJ4 CHRNA3 ASIC4 RYR2 KCNE2 SCN2B CACNA1A PRL TRPV1 CFTR SCN2A GABBR1 EDNRB CACNG2 GRID2 ADRA1A FSHR PMC4510598__F4 Fatty acids biosynthetic pathway (map 61) HEXA FASN PMC7601465__F3 Transforming growth factorB signaling in a nutshell SMAD2 TGFBR1 GRB2 TGFBR2 SMAD4 ARHA CDC42 PMC2807318__F8 Summary of the AMPK and mTOR signaling pathways RICTOR MTOR PMC4650996__F8 TRPV1 antagonist-induced hyperthermia involves BAT-mediated thermogenesis UCP1 TG TRPV1 PMC5836190__F3 Activation of the NLRP3 inflammasome in the canonical pathway NLRP3 IL16 PMC5836190__F5 Alternative pathway of NLRP3 inflammasome activation NLRP3 RIPK1 FADD PMC2896632__F1 Signaling pathway of the KRAS protein EGFR GRB2 PTEN MTOR PMC9316959__F3 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma MYC TFDP2 BAX PMC9316959__F4 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma SMAD2 EGFR MYC SMAD4 ARHA RAC1 AXL BCL9 ADAM17 CDC42 PMC7181582__F6 HIF signaling pathway and upregulated DEGs in HIF pathway from KEGG enrichment analysis of R EPO VHL TFRC IL6 PFKL HEL-S-87p MTOR HEL-S-162eP F11 HEL-S-133P CYRIA TF STAT3 PMC4392244__F9 Comparing CGN death induced by NSC23766 and ToxB TIAM1 PAK1 BAD RHO CDC42 TRIO PMC7967983__F2 Glycolysis in tumor and tumor microenvironment is associated with immunotherapy resistance PTEN MTOR IRF-1 PMC7181582__F7 NFKB signaling pathway and upregulated DEGs in NFKB signaling pathway from KEGG enrichment analysis of R CD14 EGF NGF TRADD DAO TRAF3 LTB TRAF6 TRIM25 CNTF BTK COX2 LTA BCR ATM BASH LYN LBP CD40 SYK LTBR LAT PMC9316959__F6 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma CS G6PC3 GYS1 HEL-S-87p HEL-S-162eP PMC3801060__F6 Model of p21-mediated restriction of HIV-1 and related lentiviruses in macrophages PMC5836077__F4 Agrin stimulates integrin-FAK-ILK-PAK1 mechanosignalling pathway to antagonize the Hippo pathway and activate YAP/TAZ mediated gene transcription PAK1 NF2 HEL-S-28 ARHA LATS1 LATS2 PMC8117390__F1 Polymorphisms in MicroRNA Target Sites of TGFB Signaling Pathway Genes and Susceptibility to Allergic Rhinitis HEL-S-62p TGFBR1 PMC2000831__F3 Proliferation induced by androgen independent pathways EGF TGFA PMC6470785__F5 Metabolic and signaling pathway crosstalk in tissues of animals with high inherent aerobic capacity (HIAC) and animals with low inherent aerobic capacity (LIAC) FLT1 IGF1R SRC ACLY MTOR FASN STAT3 BAX PMC5836077__F7 Concerted agrin and YAP activity in the maintenance of NMJs and promoting cardiac regeneration MUSK LRP4 PMC12047509__F1 Nrf2 signaling in Alzheimer's Disease BACE1 GCLM GPX4 KEAP1 CX3CL1 NOX4 HEL-S-128m NQO1 PMC3615883__F1 G1 to S phase cell cycle transition regulators.Abbreviations: S, synthesis; G1, Gap 1 MYC SMAD4 CDK4 CDK6 PMC6935177__F9 Working model demonstrating the regulation of Hippo signaling during ovulation LATS1 LATS2 STAR PMC3069071__F7 Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells SMO BAX PMC12092922__F4 MXRAs is involved in chemotherapy resistance HEL-S-28 SRC MXRA8 PMC5067469__F6 The signaling pathways of pathogen protective mechanisms based on HPCNs in Figure in Mϕs and DCs during Mtb infection UBC CS MOS EGFR TF RPS10 PMC6927934__F6 The cell cycle metaphase checkpoint pathway CENPB CENPH PLK1 CS PMF1 APC INCENP CENPF CDC20 RASSF1 CDC6 CDK2 CDC2 SKP2 NSL1 PMC5940789__F6 MiRNA-gene-pathway network between sixteen intersection genes, and their corresponding pathways and differentially expressed miRNAs CASP6 GABBR2 MMP2 CYP1B1 SMAD2 HSD3B2 PRKAB2 ORC2 SKP2 MYLK PMC12092922__F2 Biological function of MXRAs MMRN2 TIMP1 HEL-S-28 EGFR CASK IGFBP7 SRC HEL-S-112 RHO KIF21A PMC7372205__F1 ACE2/TMPRSS2 pathway and its interaction with SARS-CoV-2 ACE2 ADAM17 TMPRSS2 PMC7372205__F2 COVID-19 early stage pharmacologic intervention targeting Sars-CoV-2 cell entry through the ACE2/TMPRSS2 pathway ACE2 ADAM17 TMPRSS2 PMC7033461__F9 Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-Beta-Smad Signaling Pathway YAP1 SMAD2 KDM3A TGIF1 PMC6307518__F1 HMGB1-RAGE/TLR-TNFA signaling pathway HMGB1 TLR4 SIRT1 PMC10870057__F1 Molecular regulatory mechanism of dormant cancer cells APC PLK4 BMP7 CCL5 RGS2 MTOR PCNA BDH2 CDC42 PMC6333462__F1 Methyltransferases linked to regulation of autophagy CARM1 ME2 KAT8 MTOR SIRT1 SKP2 BRD4 PMC10870057__F2 Molecular regulatory mechanisms of dormant PGCCs SOX2 MYC NR2F1 RGS2 ATR AURKA AURKB CDC42 PMC3298572__F7 Model for HuR NEDDylation RRM1 RRM2 MDM2 NEDD8 PMC4214130__F5 Hypothetical pathway analysis depicts mitochondrial dysfunction PDK2 PDP2 IL1B PMC8721001__F1 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors LEF1 SOX9 PMC7675715__F1 Sensitivity of cystic fibrosis transmembrane regulator (CFTR) carriers to COVID‐19 inflammatory response ACE2 IL1B CFTR PMC8721001__F2 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors LEF1 CD44 PTEN MTOR SOX9 SOX4 PMC9094400__F1 Targeting PARP1 to Enhance Anticancer Checkpoint Immunotherapy Response: Rationale and Clinical Implications CGAS CXCL10 CCL5 PMC9424672__F5 Cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma CORT CRH TNF PMC5123368__F7 Schematic presentation shows the Adiponectin signaling pathway in neuron under normal (left) and disease (right) conditions APP IRS1 IL1B PMC5016670__F10 Signaling pathway by which TGFB1 increases DNMT1 and DNMT3a GSK3B TGFBR3 PMC9396537__F1 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming BDH1 MTOR NR1C1 SIRT1 CD36 HEL-S-5 SIRT3 PMC5993212__F7 Commonalities in epileptogenic processes from different acute brain insults. Does it translate? TSC2 HMGB1 PLCG1 TSC1 IRAK1 TRAF6 IRAK4 MYD88 MTOR BDNF PMC5105987__F11 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases SYCP3 ERBB4 IGF1 GTF3C5 NRG2 CHPT1 WWOX RXRA GNPTAB PMC5105987__F12 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases TCOF1 RIMS1 SLC6A3 ADRM1 ERC2 CEP78 CDX1 CAMK2A PMC11468018__F5 Proposed signaling pathway illustrating effects of cancer and inflammation in the kidney TRADD IRAK1 SMAD2 SMAD4 TRAF6 MYD88 TRAF2 PMC7801705__F6 NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease EEA1 RAB17 NOD2 PMC7185074__F6 ‘mTOR signaling pathway’ PTEN SLC3A2 MTOR DEPTOR EIF4B RHEB PMC9396537__F4 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming MTOR SIRT1 SIRT3 PMC4055208__F8 Scheme representing the insulin signalling pathway, the mechanisms involved in the high glucose-induced impairment of the insulin pathway and the proposed mechanism by which PPARB agonists prevent high glucose-induced insulin resistance in HUVECs PDK4 IRS1 PMC4774549__F4 Ubiquitination in the Antiviral Immune Response CGAS RNF5 RNF26 TRIM32 TRIM56 PMC4777718__F2 A view of L-homoserine biosynthesis pathway page INA RAN PMC3878307__F1 TMEFF2 AND SARDH COOPERATE TO MODULATE ONE CARBON METABOLISM AND INVASION OF PROSTATE CANCER CELLS HEL-S-182mP TMEFF2 GLDC PMC10940682__F10 Glycosylphosphatidylinositol anchor proteins (GPI-APs) play a role in several cellular signal transduction pathways CD14 CD109 TLR4 CD27 SMAD2 EGFR MYD88 FOLR1 TNF STAT3 PMC4303155__F2 MAPK signaling pathway showing the target genes of microRNAs CD14 EGF DAO MAX FLNA ECSIT PMC11730190__F4 Action of DPEP1 in malignant tumors EGFR MYC ASCL2 MTOR PMC5400654__F1 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma RBPJ SMAD2 ATF2 VTN ZEB2 SMAD4 ARHA CDH2 SMURF1 PMC9277720__F2 Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers STAT1 SOCS3 JAK3 JAK1 TNF TRAF2 STAT3 PMC5400654__F4 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma TRADD TRAF5 TRAF3 LTB RELB TRAF6 CD40 MYD88 TRAF2 LTBR PMC7226610__F4 P53-related miRNAs controls the osteoblastic differentiation through interplay with Notch, Wnt/Beta-catenin, and Sonic/Hedgehog (HH) pathways NOTCH2 LEF1 SOX2 RUNX2 FZD2 MDM2 VEGFA NOTCH1 JUND SMO PMC4180468__F10 A model for action of DOX within key signaling pathways necessary for LTF EBP CREB1 PMC3571707__F1 Adaptive Immune Responses and HER2/neu Positive Breast Cancer HMGB1 MYD88 PMC9657949__F1 MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective MYBL1 FOXO3A IGF2 MCL1 IRS1 PMC7340853__F1 Clinical promise of next-generation complement therapeutics HEL-S-62p CD46 MASP1 C4A CR1 CD59 C9 FH C5AR2 C7 C6 MASP2 CD55 C1S CP PMC9663521__F7 Protein tyrosine kinase 6 regulates activation of SRC kinase PTK6 EGFR SRC PMC5369246__F1 Signaling pathways of ATM and ATRThe DNA damage response is activated by ATM, ATR, and DNA-PKcs RAD1 FANCD2 ATM E2F2 ATRIP SSB RAD51 ATR E2F3 PMC5369246__F3 STAT-5-dependent activation of ATM and ATR pathways, required for HPV genome amplificationHigh-risk HPV activates STAT-5 to mediate TopBP1 transcriptionally to promote ATR pathway STAT1 ATM TOPBP1 ATR PMC5199628__F1 Principles of Kinase Inhibitor Therapy for Solid Tumors KIT RET ALK EGFR MTOR PMC2563957__F1 Phospholipase A2 (PLA2) catalyzes phosphatidylcholine into AA in response to agonist stimulation of a G-protein–coupled cell surface receptor COX2 COX1 PMC6590704__F1 Nuclear gene-encoded regulatory factors are essential for mitochondrial biogenesis and function NRF1 TFAM SIRT1 PMC3120887__F5 MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus MAP3K1 BAD MAP2K4 CRAT PTH DRD1 DRD2 DRD4 DRD5 DRD3 NSMAF NCS1 JUN PMC4724176__F2 Molecular signaling and the advantages of Warburg TSC2 EGF TSC1 HGF PTEN EIF4E HIF1A PDPK1 RHEB HK2 PMC7730716__F1 Schematic image of TGFB/SMAD and BMP/SMAD signaling pathway in fibrosis (upper left box, signal activation via TGFB receptor and ligand attachment; orange and yellow circles/arrows, TGFB ligands/signaling and BMP ligands/signaling, respectively) SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC8469693__F5 NFKB and Pancreatic Cancer; Chapter and Verse TLR5 TLR9 TRADD IRAK1 IRAK2 RELB IRAK4 TNF TLR8 TLR7 TLR4 REL TRAF2 TAB3 PMC9503372__F9 Disruption of the Chitin Biosynthetic Pathway Results in Significant Changes in the Cell Growth Phenotypes and Biosynthesis of Secondary Metabolites of Monascus purpureus ARL1 HEL-S-11 GIP PMC7730716__F2 Therapeutic target sites in the TGFB/BMP signaling pathway SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC6679009__F2 Canonical WNT/Beta-catenin pathway APC LRP5 LRP6 DKK1 PMC8469693__F3 NFKB and Pancreatic Cancer; Chapter and Verse IL16 BCR LTB RELB CSA2 LTBR PMC11965140__F7 Immune regulation of CORT depends on GR signaling and 11Beta-HSD CORT FOXO3A NR3C1 MTOR BDNF ARG1 FOXO1 PMC11889768__F1 Biosynthetic pathway of 2-AP DAO PRODH PMC11965140__F5 Immune activity by CORT through TREM2 IL10 CORT NLRP3 SOCS3 PLCG2 MYD88 SOCS1 STAT3 PMC11965140__F6 Multiple pathways mediate the inflammatory injury of CORT induced cell death CORT PROS1 SOCS3 MYC XBP1 GSDMD BCL6 NLRP3 FBXO11 TLR4 TFEB DLL4 MERTK AXL SOCS1 PMC10309559__F2 IFNB expression: focusing on the role of its promoter and transcription regulators TBK1 STAT1 CGAS STAT2 TRAF6 MYD88 MAVS PMC11965140__F3 Immune activation and immune imbalance induced by CORT CORT NLRP3 ATM IL33 CCL17 TREX1 CD244 CCL18 MTOR CCL22 IL1B IFI16 PMC3603375__F4 Neurotrophin signaling pathway is among the pathways downregulated in clinical T1 and upregulated in clinical T2 NGF PENK PMC3894494__F7 Proposed model of heme-induced stasis CD14 TLR4 VCAM1 VWF MYD88 TIRAP PMC3342348__F1 IL-1 signaling in the tumor microenvironment TRAF6 MYD88 TNF MAP3K7IP1 PMC3806061__F1 Diagrammatic representation of the hedgehog (Hh) signaling pathway HHIP BCL2 SMO PMC9093608__F7 Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions AIP AHI-1 SHANK3 PRNP DPP10 UNC5D HEL-S-11 ERBB2 NRXN1 UNC5B ACAN DOCK2 LINGO1 PMC10035050__F6 Sodium acetate regulates milk fat synthesis through the activation of GPR41/GPR43 signaling pathway DGAT1 ACACA FASN PMC5468686__F2 Protective or pathogenic roles of innate lymphoid cells (ILCs) in liver diseases IL13RA1 APC IL33 CXCL9 IL23R STAT3 FOXP3 PMC5920772__F3 Development and Connectivity of the Habenular Nuclei SEMA5A SHH DCC SEMA3D PMC11011033__F3 NDRGs in Breast Cancer: A Review and In Silico Analysis EGFR SGK1 PMC8079203__F8 PI3K/AKT/mTOR and autophagy signal pathway MMP2 MMP9 MTOR DKFZp686F0183 PMC9203688__F1 Ferroptosis and Autoimmune Diseases HMGB1 GPX4 IL6 PMC4988275__F1 Cellular and molecular events of autophagy–lysosomal pathway ATG12 ATG3 ATG10 MTOR DKFZp686F0183 PMC3684083__F4 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets EGF MTOR TGFA PMC3684083__F2 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets BRAF BMP2 SMAD2 TGFBR1 SMAD4 MTOR PMC3684083__F1 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets EGF BRAF EGFR MTOR TGFA GHRH PMC11821961__F1 Two NFKB signaling pathways include the classical (canonical) and alternative (noncanonical) routes TRADD IRAK1 RELB TRAF3 LTB TRAF6 IRAK4 MYD88 MAP3K7IP1 BTK LTA BCR TRAF5 BASH CYLD RELA LCK LYN CD40 SYK TRAF2 LTBR LAT TIRAP PMC8602792__F4 Novel Therapeutic Targets in Liver Fibrosis SUFU GSK3B SMO PMC7082882__F3 How PHB1 exerts tumor suppression in the liver MAF MAX IGF2 CTCF PMC7799025__F1 IL-6 receptor and signaling GAB2 TRAF3 STAT3 PMC12160120__F3 Mechanism and effects of the cGAS-STING pathway in regulating antitumor immunity across T cell subsets BATF3 TBK1 CGAS CD27 TNLG8A TREX1 NOS2 GATA3 FOXP3 PMC12160120__F4 CGAS-STING pathway regulates TAM polarization and anti-tumor immune effect STAT1 CGAS TFEB IRF3 CXCL2 PMC12160120__F5 CGAS-STING interaction network with other immune cells and its regulatory role in tumor immunity EEF2K CGAS PC CXCL9 ARG1 SOCS1 CD68 STAT3 PMC8736280__F1 Vasculopathy in COVID-19 MAS1 CD59 CS PC PLG FDPS APC CNP KLF2 CD55 RAC1 ACE2 PMC11899857__F7 NFATc1 plays a central role in regulating the expression of downstream genes and proteins, including CTSK, MMP9, DCstamp, integrin B3, ATP6v0d2, and ACP5 CTSK NFATC1 MMP9 DCSTAMP ACP5 ATP6V0D2 PMC12160120__F6 Interactions and regulatory mechanisms between the cGAS-STING pathway and other components within the TIME TBK1 STAT1 CXCL10 CXCL9 IRF3 STAT3 PMC2082128__F7 Biosynthetic pathway for the ganglio-series of glycosphingolipids ST8SIA5 B4GALNT1 ST8SIA1 B3GALT4 ST3GAL5 PMC12160120__F7 Synergistic Mechanisms and Translational Potential of cGAS-STING Pathway Combined with Other Therapies IRF3 TNF PMC8758994__F1 De novo lipogenesis HEL-S-26 CIC ACSS2 ACLY PMC4703083__F5 The proposed biosynthetic and maintenance pathways for the metallocofactors of the class Ia (a), Ib (b), and Ic (c) ribonucleotide reductases FEV F11 PMC8557169__F4 Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team FADD BAX PMC9497596__F7 Full-Length Transcriptome Sequencing Combined with RNA-Seq to Analyze Genes Related to Terpenoid Biosynthesis in Cinnamomum burmannii ME2 MVK IPP PMC8758994__F3 Physiological regulation of DNL CIC ACLY RFWD2 PMC3929107__F1 Regulation of Hippo pathway and implications for anticancer drug development LATS1 SPHK1 RHO LPA LATS2 PMC12160120__F1 CGAS-STING signaling pathway mechanism TBK1 CGAS IRF3 STIM1 PMC12160120__F2 Mechanisms and Roles of cGAS-STING Pathway in Regulating DC Subpopulations for Antitumor Immunity XCR1 TH CGAS PDC CD27 TNLG8A CXCL10 CCR7 CXCL9 CD40 CCL5 CCL4 PMC4303659__F10 Working hypothesis for how the PGRN/PIRO axis regulates the formation of multinucleated osteoclasts NFATC1 OSCAR TRAF6 PMC2390572__F10 MCF10A Pathway 2 affected by TFIIS knockdown METAP2 PVALB IL24 ATF5 LTB4R GNG3 PPP1R15A SHC2 INSIG1 PLD2 ACADVL SLK GNB1 PMC6054955__F4 Immune Responses of Epinephelus coioides to sigX IL10 BCR CXCR4 C7 C6 CD40 ICOS PMC8466051__F2 VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles RBPJ VAV1 NOTCH1 PMC8070086__F6 Putative mechanisms of TRIB3-mediated AKT signaling inhibition RICTOR BAD TRIB3 MTOR MLST8 PMC4363166__F4 An extended signaling pathway that regulates basal P-glycoprotein activity at the blood-brain barrier S1PR1 MTOR PMC11465851__F3 Pattern recognition receptors on ependymal cells are involved in inflammatory signaling The TLR4/MyD88/NFKB signaling pathway induces the release of inflammatory cytokines like IL-1B and TNFA, while promoting phagocytic apoptosis CD14 TLR4 TLR9 MYD88 TNF FOXJ1 PMC6679009__F5 Beneficial role of NSAIDs in cancer process APC GSK3B TNF STAT3 BAX PMC6562376__F1 B1 integrin induces EGFR- or HER (ErbB2)-targeted therapy resistance EGF ERBB2 NRP1 EGFR SRC PMC6562376__F3 B3/KRAS/RalB/NFkB pathway mediates EGFR-targeted therapy resistance EGF EGFR RALB PMC3649103__F2 Hepatic ethanol metabolism LPL HEL-S-70p TG IRS1 PMC9501546__F5 TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway FGFR1 HRAS TTYH3 PMC3763909__F2 The role of androgens/AR in acne formation/progression IGF1 FOXO1 PMC3649103__F1 Hepatic glucose metabolism APOB TG IRS1 FOXO1 PMC8976637__F2 Disease: Recessive ADAMTSL4 Mutations and Craniosynostosis with Ectopia Lentis CS FBN1 SKI PMC8427595__F7 Dengue Virus Dysregulates Master Transcription Factors and PI3K/AKT/mTOR Signaling Pathway in Megakaryocytes TPO MTOR GATA2 PMC8938628__F12 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway APC GSK3B LRP5 LRP6 BCL9 TCF4 PMC3429047__F5 Simplified illustration of the canonical Wnt signaling pathway APC LRP5 LRP6 PMC2747168__F1 Acp-group transfer catalyzed by PhTYW2 TYW3 TYW1 PMC8863366__F1 Blocking cholesterol storage to treat Alzheimer’s disease NPC1 ACAT1 ABCA1 NPC2 APOE PMC7249037__F5 KEGG pathway for ovarian cancer TH CS ATM MYC RORA MME SIL1 LAT PMC7249037__F6 KEGG pathway for colorectal cancer CASP3 BAD POLK AREG APC EGFR CASP9 SMAD4 MTOR DCC JUN BAX PMC5743003__F1 Signaling pathways involved in the pathogenesis of MPNs and secondary AML EPOR EPO ASXL1 MDM2 GRB2 HEL-S-99n TPO EZH2 MTOR MPL TET2 PMC7249037__F7 KEGG pathway for breast cancer POLE SHE PTEN RAN PMC3107100__F1 Genetic alterations in glioblastoma signal transduction pathways (adapted from Parsons et al) NF1 CDKN2B TP63 EGFR MDM2 SRC PTEN PMC9961805__F1 E’Jiao on Skeletal Mineralisation, Osteocyte and WNT Signalling Inhibitors in Ovariectomised Rats APC SOST LRP5 LRP6 PMC3868343__F2 Molecular basis for synergistic activation through pairs of coactivation receptors on NK cells FYN SYK CBL PMC9030606__F1 Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies TH NLRP3 IRF7 MPC1 HDAC2 PARP1 IRF3 TYK2 JAK1 ACE2 NOD2 MAVS PMC10814280__F1 RABV-induced incomplete autophagy ULK1 ATG12 ATG3 IFITM3 CASP2 PMC10221447__F3 Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review TNF BAX PMC3907121__F1 Cardiovascular Effects of Erythropoietin: An Update EPOR BAD EPO BCR GRB2 STAT3 PMC2917029__F8 Molecular pathway initiated by P4 signaling in BPBC cells EGF EGFR PTEN PMC8018074__F8 Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/B‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide MBP APC GSK3B OLIG1 SOX10 AXIN2 IL1B OLIG2 TCF4 PMC3667241__F1 Schematic drawings of the neuronal signaling pathways of anorexigenic and anxiogenic-like action in goldfish NMU CCK GNRH2 CRH PMC7675040__F4 Alteration in DNA repair mechanism in esophageal cells chronically treated with cigarette smoke condensate CCNK EVL CHEK2 CLSPN ATM CDK2 TP73 EZH2 MED1 TNFRSF10A ATR PRKDC MGA PCNA PMC11593047__F3 Contribution of Sox17-induced gene products to the maintenance of the hematopoietic capacity and cluster formation RUNX1 SMAD2 TGFBR1 GSK3B ESAM NOTCH1 SOX18 SOX17 SOX7 HES1 GATA2 GATA1 PMC3432190__F2 Concept of molecular network in schizophrenia PLCG1 PLSCR1 TH EGF NGF EGFR MYC SCGB1A1 HDC PRKCA PLD2 PC DDC SRC CAD IL4 ARG1 ACTN4 PTGS2 VEGFA NTRK3 ALDH18A1 ADH1A LRAT PLA2G1B PRODH KLF4 POLR3C HEL-S-36 ARF6 BDNF ASS1 ASL TCF4 CDC42 ALDH2 PMC10421513__F10 Structure Characterization and Immunomodulatory Activity of Misgurnus anguillicaudatus Carbohydrates TRAF6 ECSIT MYD88 MAP3K7IP1 JUN TIRAP PMC6479730__F1 General representation of the signaling pathways involved in the antagonism of both ionotropic and metabotropic glutamate receptors in anti-cancer mediated effects MTOR SMAD1 DKFZp781O1323 PMC8238076__F5 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation GNE NUMB TREM1 ASXL2 AREG TBX2 DOCK8 ATF3 CDKN2A AURKB MEF2D PMC8238076__F6 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation WEE1 ATR MYT1 PMC6792082__F7 Targeting NRF2 antioxidant pathway for IDH1-mutated cancers MAF ME1 GCLM KEAP1 GCLC PMC10373932__F5 Insights into the physiological and genomic characterization of three bacterial isolates from a highly alkaline, terrestrial serpentinizing system AMT PMC8161999__F6 Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer MYB BAD MEI1 TRADD DAO EBP TSC2 PC POLE MAX HP MAFK SI APP SYK APMAP RBL2 CD19 PMC11555182__F1 KEAP1-NFE2L2 signaling pathway KEAP1 NFE2L2 RBX1 PMC11711403__F9 Model depicting PBLD and Cedrelone inhibit viral replication via activating the NFKB-mediated IFN-I signaling response HEL-S-306 IRF9 TRIM21 PMC9160962__F1 Methyl Metabolism and the Clock: An Ancient Story With New Perspectives BHMT2 MTHFD2L SLC25A32 SHMT1 AHCYL2 FPGS MTHFD2 ALDH7A1 ADI1 SLC25A26 APIP HEL-S-70p FOLR1 SMS SLC19A1 CTH MTFMT CHDH DLD FTCD MTHFD1 AMD1 SLC46A1 HEL-S-61p MTR MAT1A ENOPH1 SRM MTRR DHFR TYMS GLDC HEL-S-51e MTHFS MTHFD1L PMC9355787__F1 COL1A2, AKT3 genes, and related signaling pathway in the pathology of congenital talipes equinovarus GSK3B COL1A2 MTOR AKT3 PMC3287489__F2 Cell cycle pathway and the significant genes on cell cycle-related miRNAs CDC20 CDK2 MDM2 CDK7 PCNA SKP2 PMC3978385__F3 NRAS mutant melanoma: biological behavior and future strategies for therapeutic management BRAF GRB2 PMC3787923__F2 The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer EGFR MAPK1 PTEN MTOR PMC11555182__F2 NFE2L2-dependent genes in ferroptosis HERC2 GPX4 FACL4 SLC7A11 FTH1 PIR NFE2L2 FTL TFRC HMOX1 NQO1 ABCB6 FECH AIFM2 MGST1 MT1G HEL-S-64p HEL-75 SLC3A2 SLC40A1 PMC8144126__F9 Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease CD14 TLR4 MYD88 TG NR1C1 PMC5007850__F7 Diagram summarizing the proposed mechanism by which MACC1 drives resistance to trastuzumab MACC1 HEL-S-133P HK2 PMC6372189__F3 A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster ALOX15B ALOX15 ALOX12 ALOX5 PMC8640456__F3 An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication PLN BCR CAV3 HRC MCU CAV2 PMC5689670__F8 Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/Beta-catenin signaling pathway MMP2 MMP9 CDK4 CCNE1 BAX PMC6923843__F5 Gene functional and Network pathway analysis of TRAP1, HSPD1, HSPB1, HSPA1L and HSPA1A HEL-S-102 HSPD1 PMC9032823__F7 Metabolism of the Genus Guyparkeria Revealed by Pangenome Analysis HEL107 RPE PMC3627964__F2 Proposed roles of Msi1-like (MSIL) proteins as regulators of the nutrient- and stress-sensing signaling pathways in fungi MSI1 MSL1 CDC42 PMC8250137__F3 COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality LEPR IRS1 AK1 STAT3 PMC4095859__F3 Metabolic requirements for the maintenance of self-renewing stem cells PML MTOR FASN PMC5668879__F10 Proposed effect of polyP and retinol on the expression of the fatty acid binding protein 4 (FABP4) and leptin/leptin receptor DLL4 VEGFA RAF1 MTOR HEL-S-104 FOXO1 HEL-S-4 PMC4095859__F4 Metabolic requirements for the maintenance of self-renewing stem cells ATM CRIPTO MTOR PMC3061506__F1 Integration of the identified proteins into the canonical pathway of TLR signaling JUN PMC9202997__F3 Impact of Air Pollution on the Course of Cystic Fibrosis: A Review BAD ATM NPS PROX2 HMOX1 ASL CFTR BAX PMC3626841__F4 Original model by Neumann et al CASP3 CASP8 FADD PMC2667788__F3 Paracrine mechanisms in adult stem cell signaling and therapy BAD WNT3A EPO HGF IGF1 HEL-S-28 IL11 RAMP3 RAMP2 STAT3 BAX PMC5716829__F1 Different PPGL molecular subgroups with corresponding driver mutations and a proportion of hereditary disease in the respective cluster SDHC MAML3 MYC VHL MTOR HRAS TMEM127 NF1 RET MAX FH SDHD SDHAF2 SDHA CSDE1 SDHB PMC7576599__F1 Emerging role of the Hippo pathway in autophagy ULK1 ATG16L1 ATG12 ATG3 WIPI2 ATG101 ATG14 PMC10373173__F2 Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review MYC TNF PMC6428091__F1 Cytosolic glucose enters glycolysis and pentose phosphate pathways PEX10 LPA TNLG7C PEX3 GLA GPD1 PMC8360179__F5 Plastidial acyl carrier protein Δ9‐desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum PC DES LPA HEL-S-5 PMC5678884__F9 Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus CDC42 PMC4810057__F2 The signaling network of JAK/STATs in IBD STAT1 STAT2 STAT4 TYK2 JAK3 JAK1 STAT3 PMC7359838__F1 Spliceosome pathway (hsa/dre03040) as enriched in module ME01 (Bonferroni correction < .05) NHP2L1 CHERP ISY1 SNRNP27 SLU7 PUF60 MAGOH RBM22 AQR PMC11595780__F4 Intratumoral microbiota promotes tumorigenesis and tumor progression through several mechanisms STAT3 PMC6209728__F2 Osteocyte role in MM bone disease LRP5 LRP6 TNF CCL3 PMC10814280__F2 : promotion : inhabition GPR17 BCL2 BAX PMC7588592__F2 New molecular targeted drugs EGFR VIP PMC6770025__F1 Synthesis of steroid hormones in humans HSD3B2 HSD17B1 SRD5A2 HSD17B2 POR CYP17A1 CYP21A2 STAR PMC4184910__F1 Schematic diagram and proposed model for the metabolic regulation and coordination of the leptin mediated reproductive and nutritional axes POMC IGF1 NPY AgRP MC4R ARC LEPR INSR PMC9688847__F1 Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1A/PPARA Players MTAP MTR SHMT1 SRM GLDC HEL-S-51e SMS PMC5649203__F2 Metabolic requirements of effector CD8+ T cells (Teff) CPT1A MTOR CD36 PMC9412206__F1 Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity—a narrative review NOTCH2 IRX3 EPOR TBX20 NUMB MIB1 PRDM16 NPPA EPO SEMA3A NRG1 JARID2 SLIT2 FKBP1A RARA INO80 ERBB4 HEY2 BMP10 ERBB2 TBX5 YY1 PMC4995918__F2 mf regulated mTOR signaling pathway in human DC RHO EIF4E MTOR IRS1 RHEB INSR TSC2 RICTOR TSC1 PC ELF3 RPS6 EIF4B PMC12149389__F9 CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury HMGB1 CMTM7 TLR4 MYD88 PMC11992894__F9 General schematic view of enzymatic browning (EB) in apple pulp and proposed pectin-related signaling pathway MYB ERF PMC8295688__F1 Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection NLRP3 ACE2 IL1B TMPRSS2 GSDMD IFNG PMC7215355__F1 Lipid metabolic processes during HCV RNA replication, assembly, and egress PC SCD OSBP MTTP CIDEB APOE PMC4938033__F3 Enhanced Ca2+ and ROS levels in cardiac hypertrophy PLN RYR2 GATA4 PMC3707373__F1 Regulation of Th9-Type Pulmonary Immune Responses. A New Role for COX-2 IL25 IL17RB PMC7076221__F8 Working model for protective effects of SIRT1 via HAS2–AS1 and NFKB HAS2 COCH SIRT1 PMC10747773__F4 HCV-induced ROS/JNK/Itch signaling pathway promotes VSP4A polyubiquitylation, leading to enhancement of VPS4A ATPase activity, thereby upregulating the release of HCV particles CHMP1B VPS4A ITCH PMC3757331__F8 Revisiting MPF activation MOS ARPP19 CDC2 MYT1 PMC3582273__F1 CluePedia analysis example using expression data from human normal colon mucosa and colorectal tumors and in silico information SOCS3 CX3CL1 IFNGR2 IFNG MADCAM1 STAT1 PDE6C LAP3 VCAM1 PTPN1 PTPN11 PIAS1 IL17A PDCD1LG2 B3GALT2 NPTN PTPN6 JAK1 IFNGR1 SOCS1 ICOS SUMO1 PMC3836209__F1 Metabolism of adenosine ADA PNP PMC6357837__F7 Working model of cholestasis in Pemt+/+ and Pemt–/– mice fed the HFD PC ATP8B1 PEMT PMC7806659__F10 The proposed hypothesis model showing that miR-148a-3p positively regulates neuronal apoptosis via activating the PI3K-AKT signaling pathway by targeting SYNJ1 SYNJ1 BAD CASP9 MTOR PMC5742211__F1 Simplified pathway of de novo sphingolipid synthesis DES SPHK1 SPHK2 PMC6468702__F3 Sub-genomic flavivirus RNAs (sfRNAs) impair cellular response to viral infection G3BP2 XRN1 TRIM25 PMC5652078__F2 HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles CDK4 MTOR CDK6 GATA3 PMC4588911__F1 IL-33/ST2 signaling pathway in mast cells IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC9448875__F7 Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway NOD1 CCL2 CCL1 CDC42 PMC9533135__F8 Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells SOX2 FGF3 FGF10 PMC6473623__F1 Autophagy-A highly conservative cascaded regulatory mechanism upholds the intracellular homeostasis of the biological system ATG12 ATG3 WIPI1 LAMP2 BCL2 STX17 ATG10 MTOR DKFZp686F0183 NBR1 PMC2999341__F12 Regulatory PathRNet Only nodes that are close to P38 MAPK Signaling pathway or "S-7" are kept (distance<3) HEL-S-62p C7 PMC6473623__F2 Autophagy Intertwines with Different Diseases ULK1 ATG16L1 ATG12 ATG3 HSBP1 LAMP2 ATG10 BMF DKFZp686F0183 WDFY3 SYNPO2 TUFM SAFB2 WIPI1 ATM DVL2 STX17 TRAPPC12 ACD MEFV AIM2 PMC7352608__F2 Therapeutic approaches of splicing modulation in cancer U2AF1 U2AF2 PMC5818153__F1 Sphingolipid metabolism in cancer signalling and therapy SPTLC1 DES SPHK2 PC CERS3 LASS1 SMPD1 CERS5 SPHK1 CERK SMS CERS2 CERS6 PMC2921082__F1 Adenosine monophosphate-activated protein kinase pathway in hepatic fuel metabolism TSC2 TSC1 MTOR IRS1 PMC9473879__F9 Network Pharmacology and Experimental Verification Revealed the Mechanism of Yiqi Jianpi Recipe on Chronic Obstructive Pulmonary Disease H1-0 FOS EGFR JUN STAT3 PMC2921082__F4 Dual regulation of fuel metabolism and cell viability by adenosine monophosphate-activated protein kinase TSC1 GSK3B MTOR IRS1 PMC5863198__F1 All roads lead to Rome: vascular inflammation NLRP3 RAC1 IL1B PMC4722285__F6 Schematic model of downstream signaling after GPCR activation PLCG1 GIP RAC1 PMC3096079__F1 mTOR regulation pathway involved in hypoxia EPO VHL EIF4E MTOR PMC9408823__F8 FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease GSK3B ABO HEL-S-15 CDK5 MARK1 IRS1 PDPK1 INSR CBL STAT1 FYN SRC CDC2 RPS6 PXN STAT3 PMC8231806__F6 Dietary Curcumin Alleviated Acute Ileum Damage of Ducks (Anas platyrhynchos) Induced by AFB1 through Regulating Nrf2-ARE and NFKB Signaling Pathways NLRP3 GCLM TLR4 KEAP1 GCLC RELA TXNIP NQO1 PMC6770582__F6 Schema of the present study PRSS1 FUT4 BHLHE41 CPNE8 NOL4L PMC7551072__F1 Regulation of metabolism by B vitamins HEL-S-61p DHFR PMC8800364__F5 Immunometabolism in biofilm infection: lessons from cancer VEGFA CD40 NOS2 PMC4125180__F8 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis SRC BCL2 STAR BAX PMC8800364__F7 Immunometabolism in biofilm infection: lessons from cancer TNF NR1C1 STAT3 CD36 PMC7281690__F1 Role of WNT/TGFB signaling pathways in pathogenesis of cardiac fibrosis SMAD2 APC TGFBR1 SMAD4 TGFBI PMC4125180__F3 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis CD14 TNFRSF12A GEM ARG2 MT2A IGFBP2 RYR3 RHOB PMC9379405__F7 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7281690__F2 Crosstalk between microRNAs and WNT/TGFB signaling pathways in cardiac fibrosis TGFBR1 IL6 RHO PTEN TGFB1 STAT3 PMC4956099__F8 ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle ATM ATRIP XPC XPA DDB2 ATR PMC9379405__F5 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways HES5 NUMB FURIN CCND3 NEDD4 HES1 PMC9379405__F6 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways ZNRF3 RNF43 APC GSK3B LRP5 MYC LRP6 RAC1 GPR49 MTOR MAP3K7IP1 LGR6 NLK CYLD NR1C2 CCND1 JUN BCL9 WLS PMC5566524__F9 TF-FVIIa-dependent PAR2-activated signaling pathway that accounts for Beta-catenin accumulation and expression of metastatic proteins leading to enhanced migration and invasion of human breast cancer cells APC GSK3B TF PMC7525004__F3 Genetic and pharmacological activation of Wnt/Beta-catenin promotes neurogenesis in the hippocampus of AD models WNT3 WNT3A APC GSK3B LRP5 CCND1 LRP6 NEUROD1 PMC8169867__F8 EGFR-HIF1A signaling pathway in Th9 cells EGFR NOS2 HIF1A TSLP PMC9633314__F5 Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer EML4 ALK FGFR3 PMC7289676__F1 ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective ATR ACE2 PMC7102037__F2 Hyperglycemia-induced lung diseases RHO ASL STAT3 PMC3974425__F5 Ezrin expression and cell survival regulation in colorectal cancer EGF FOS PTGS2 MMP9 EZR ARHA BCL2L1 RAC1 ARHG MMP14 MMP2 TNFRSF1A SRC DCC JUN BAX PMC3932036__F5 Akt signaling pathway TSC2 BAD TSC1 HEL-S-28 GRB2 CDC37 PTEN EIF4E MTOR RHEB PMC8771160__F8 Pyridinium-type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of Beta-catenin APC GSK3B MYC CCND1 JUN TCF4 PMC2742090__F4 Negative feedback loops in the SHH signaling pathway driven by SHH-binding proteins BOC SHH GAS1 PMC9175009__F2 Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics NLRP3 PTMS TRIM21 MYD88 IL1B FADD TRIM65 GSDMD PMC2709066__F1 De novo purine synthesis pathway PFAS ADSL PMC10177184__F6 Evolutionary chart of human molecular pathway Akt IGF1R BAD PDK2 GSK3B PTEN LY96 MYD88 MTOR RPTOR TLR4 MDM2 SRC CCND1 SGK1 CD19 PTK6 ITGB1BP2 WNK1 GSK3A HBEGF CDC37 DBT TBC1D4 BRCA1 FOXO1 GATA2 MLST8 RS1 TSC2 TSC1 GAB2 GRB2 SYK BCAP31 TIRAP PHLPP1 ACIN1 PMC11027554__F2 "hit and run" mechanism posits a potential role for H SRC BRCA1 ADAM17 PMC10177184__F7 Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways MUC1 EGF MAP3K1 MAP2 CSK EGFR RHO RAC1 CBL PAK1 MAP2K1 SUFU GRB2 SRC SMO JAK1 USP6NL PMC5463383__F7 Proposed model showing the mechanism of action of PPARG agonists (TRG and RSG) on TGFB1-induced fibrogenic activation in human primary intestinal myofibroblasts SMAD2 SMAD4 PMC8833361__F8 Time Series Ovarian Transcriptome Analyses of the Porcine Estrous Cycle Reveals Gene Expression Changes during Steroid Metabolism and Corpus Luteum Development DKFZp686L0365 TH HHIP PTCH2 HP HEL-S-11 BCL2 SMO KIN PMC10177184__F9 Evolutionary chart of human molecular pathway of WNT signaling CLDN1 APC GSK3B LRP5 NRCAM ARHA RAC1 WIF1 FRZB MMP7 COX2 NR1C2 CCND1 ENC1 PMC3075371__F1 Local control of Beta-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient INA HEL-S-11 PMC3407375__F3 MicroRNA Circuits in Transforming Growth FactorB actions and Diabetic Nephropathy USF1 YBX1 ZEB2 MDM2 PMC6753331__F1 MiR-155 is expressed in plasma (P), monocytes, fibroblast-like synoviocytes (RASF) and synovial fluid monocytes (SFCD14*C) of patients with RA/JIA STAT1 TLR4 APAF1 IRAK1 TRAF6 IRF3 CASP10 SOCS1 PMC7797856__F5 Six core genes (COMP, SPP1, COL1A1, IL6, VWF, TEK) were significantly enriched in the PI3K-Akt signaling pathway BAD CDC37 PTEN EIF4E MTOR IRS1 BRCA1 TSC2 TSC1 BCR MDM2 GRB2 CCND1 SYK EIF4B RBL2 BOLL CD19 PMC8375323__F9 TIMM17A Regulatory Network Contributing to Breast Cancer KIF23 CCNA2 TBCE PLK1 FOXM1 BLM BIRC5 KIFC1 TROAP TOP2A DTL CCNE1 E2F2 RRM2 CCNB1 NUP133 PAICS CDC2 EZH2 DLGAP5 SPC25 MYBL2 ANAPC7 NCL MAD2L1 NUCKS1 CENPE HCTP4 UHRF1 CHEK1 TK1 CDC20 HMMR MCM2 CDC6 NCAPG NEK2 PMC3466334__F3 Genetically-defined metabolic reprogramming in cancer HEL-S-26 KEAP1 FH PMC7227004__F1 YAP/TAZ activity is tightly regulated—Hippo signaling and beyond EGR1 ERBB4 RUNX3 RUNX2 EGFR LATS1 LATS2 CBFB PMC3466334__F1 Genetically-defined metabolic reprogramming in cancer CIT PHGDH MAL PMC3974514__F1 Metabolic pathway of azathioprine/mercaptopurine metabolism TPMT PMC8375323__F4 TIMM17A Regulatory Network Contributing to Breast Cancer C18orf55 TIMM17B TIMM22 DNAJC19 ATP5G1 SLC25A4 GRPEL2 TIMM17A PMC6723645__F1 Pathway inhibition by targeted agents and their effects on cell proliferation, apoptosis, metastasis and angiogenesis FOS MYC GRB2 SOS1 JUN PMC2871922__F4 Regulation of spermatogenesis processes by non-classical testosterone signalling EGFR FSHR PMC2574672__F2 Iron–sulfur (Fe-S) cluster biogenesis in eukaryotes NUBP2 ABCB7 CIAO1 FES FXN NARF ISCU HSCB NUBP1 FDXR PMC4530367__F1 Alternative pathway of the complement system.The activation of the alternative pathway of the complement system depends on spontaneous hydrolysis of complement factor 3 (C3) in plasma leading to the formation of C3(H2O) HEL-S-62p C9 FH C7 C6 PMC5633564__F1 Folic acid and the one carbon cycle (1-CC) PMC6900372__F4 The results of pathway enrichment analysis ITGAM VASP CD99 ARHH CXCR4 TEC JAM3 ARHA ITGA4 RAC1 JAM2 THY1 PMC5363986__F1 The Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt APC GPR49 HES1 PMC7767525__F1 Summary of the activity of FANC proteins in the FA/BRCA pathway REV1 GIG8 SLX4 FAAP24 FANCM RFWD3 ATR BRCA1 USP1 PMC7767525__F2 Major mechanisms of double-strand break repair POLE FANCD2 CYREN HMCES RAD51 PARP1 PMC9233184__F1 Complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics CYR61 TET3 HEL-S-28 EGFR SRC GSC HIF1A TGFB1 STAT3 PMC2940983__F1 Histone GH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers ATM MDC1 ATR H2AX BRCA1 PMC8015888__F8 Immune detection, inflammatory signaling and intracellular fate of MVs produced by Gram‐positive bacteria TLR8 TLR7 TLR9 CCL2 NOD2 PMC4598198__F2 effect of lipoxins on cytoplasmic signaling cascades and transcription factors.Notes: Lipoxin binds to its G protein-coupled receptor ALX/Formyl peptidyl receptor triggering a wide array of cytoplasmic signaling cascades EGR1 NAB1 MPO TNF MTOR PMC11872610__F1 Design and preparation of Qu-CDs for the treatment of burn wound healing GIG8 ID4 CDH2 ARG1 ID1 SMAD1 ID3 DKFZp781O1323 PMC5862596__F1 Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas EGFR HEL-S-162eP PMC9287179__F8 Mechanism of the ANKFN1 gene in HCC GRB2 CCND1 ARHA CDK4 PCNA CDK6 PMC10537516__F1 IL-15 and N-803 for HIV Cure Approaches SOCS3 PTPN1 IL15RA JAK3 JAK1 PMC2836046__F7 Proposal of the regulatory loop of miR-24, miR-34a, and HNF4A in bile acid synthesis CYP27A1 CYP8B1 CYP7A1 PMC8997790__F3 Vitamin D and Hypoxia: Points of Interplay in Cancer TSC2 TSC1 NR1i1 PLK3 PTEN EIF4E HIF1A DDIT4 RHEB PMC5520163__F1 How the MyD88 pathway triggers the ubiquitylation of IRAK1 IRAK1 TRAF6 IRAK4 MYD88 PMC3850498__F1 Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells IL18 PGP ARHA HIF1A IPP PMC12037491__F7 Possible mechanism of central tolerance of thymic T cells induced by H CHMP5 APC ZAP70 GRB2 TRAF6 PMC6785648__F1 Important factors involved in the pathogenicity of septic shock caused by LPS from gram-negative bacteria HMGB1 PLTP TLR4 LBP LDLR IRF3 TF PMC8569819__F8 TNF signaling Kegg Pathway report for up-regulated DEGS caused by WYE (Low) 15 μg/ml vs. untreated controls after meeting selection criteria; -2+2 fold change, p-Value <0.05 and FDR p-Value <0.05. Up-regulated DEGS are demarcated by a red star EDN1 HEL-S-11 CIC TNF FADD ITCH PMC3050939__F3 Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis PGGT1B MVK IDI1 HMGCS1 IPP GGPS1 HMGCR PMVK MVD DHCR7 FDPS FDFT1 RABGGTB PMC3328748__F11 The molecular players involved in angiogenesis signalling mediated by the interaction of VEGF-A with VEGFR-2 GRB2 SHE RAF1 PMC6461577__F8 Fludarabine Improves NDV-Mediated Oncolytic Viro-immunotherapyOn the one hand, the viral RNA activates the cytoplasmic RIG-I signaling pathway in the host cells to produce type I IFNs or other antiviral molecules STAT1 IDO1 IRF7 IRF3 IFNAR1 MAVS STAT3 PMC7460249__F1 Metabolic reprogramming in cancer GOT2 MYC CD36 HEL-S-5 PMC2737689__F2 Multiple isoforms catalyze each step in the glycerol-3-phosphate pathway of TAG synthesis HMFN0839 DGAT1 GPAT4 PC GPAT2 DGAT2 AGPAT3 AGPAT4 ACSL1 LPA AGPAT5 PMC2889025__F2 P53 stabilization ATM MYC MDM2 ATR PMC2907396__F3 Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue NFATC2 FYN RELA GRB2 JUN NFATC3 LAT CBL PMC8646611__F5 Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated Microthrombosis FGA F13A1 HRG ITGA2B ALB IL6 CCL2 HMOX1 TLR4 CXCR4 APP FURIN SELP SP1 PMC2907574__F4 Inhibition of host signalling pathways by VACV members of A46 and related families TBK1 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 MAP3K8 TIRAP PMC2889025__F1 Response of p53 to DSBs generated by ionizing radiation ATM CDK2 MDM2 ATR CDC45 BAX PMC5825991__F2 Targeting pattern-recognition receptor signaling in human intestinal inflammation TBK1 TLR9 RP1 IRAK2 TLR1 PMC3983064__F9 Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation CARD9 TLR9 SYK MYD88 TNF IL1B NOD2 PMC4679489__F2 Critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 UNK TAB3 MAL PMC2889025__F4 Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization ATM MDM2 PTEN ATR PMC4235299__F1 Genes for which a correlation with Wnt/Beta-catenin signaling was indicated by MetaCore pathway analysis MED12 APC CNKSR3 CCNC PMC4243082__F1 Regulatory network of cell-fate decision upon DNA damage involving (A) the G1/S checkpoint arrest network and (B) the senescence regulatory pathway CHEK2 ATM MDM2 RB1 ATR CHEK1 PMC9516659__F2 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data CENPH CENPM SLC1A4 HPS5 FCN3 ODZ1 DFNB31 CENPL MBL2 CENPK NDP FCN2 LILRB5 CENPW MPC1 MASP2 CENPA PMC9516659__F3 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data E2F4 RABL6 MCM2 FOXM1 BUB1B CENPF NEK2 MCM10 EZH2 TOP2A FOXO1 PMC9516659__F4 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data CFD THBD SCD GSTA3 LEPR ID1 THRSP PMC4905575__F3 PP2A positively and negatively regulates the Wnt signaling pathway APC GSK3B PMC4905575__F4 PP2A negatively regulates the mTOR signaling pathway ULK1 APC GSK3B TBC1D7 RAC1 MTOR IRS1 RHEB MLST8 TSC2 RICTOR TSC1 GRB10 PMC7665448__F2 SARS-CoV-2 infects the host through angiotensin-converting enzyme (ACE) 2 receptors which are elevated in inflammatory conditions CRP IL33 ACE2 PMC7591896__F1A Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus RELT NODAL BMF TNF TNLG7C OSM INHBA PMC6565995__F2 Gene coexpression network for trans-1,4-polyisoprene biosynthesis involving mevalonate and methylerythritol phosphate pathways in Eucommia ulmoides Oliver MVD ACAT1 FDPS MVK HMGCS1 HMGCR ACAT2 PMC4465592__F1 Attacking the Multi-tiered Proteolytic Pathology of COPD: New Insights from Basic and Translational Studies MMP9 IL8RB PMC3742039__F3 Gene expression in keratinocytes related to IL-1 signaling IL1A PLG LIF EGFR PTPN11 IL6 PMC8807458__F3 Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering SMAD2 SMAD4 PMC3382313__F1 The role of Notch ligands in our models TH STAT1 TLR9 STAT2 DLL4 TYK2 MYD88 JAK1 PMC7346118__F3 Pathways involved in polymyxin-induced nephrotoxicity and the potential nephro-protective mechanism of curcumin NOX4 FADD PMC9534868__F2 Activation of the canonical Wnt signaling pathway ZNRF3 RNF43 APC LRP6 PMC5777756__F8 Insufficient microwave ablation-induced promotion of distant metastasis is suppressed by Beta-catenin pathway inhibition in breast cancer LEF1 CDH2 PMC3676786__F1 Representative anti-angiogenic drugs and their targets in the angiogenic pathway KIT VEGFA RAF1 FLT3 PMC3372917__F1 PTPN11-Associated Mutations in the Heart: Has LEOPARD changed its RASpots? NF1 TSC2 CS BRAF GRB2 SPRED1 SHOC2 RAF1 SOS1 MTOR CBL PMC4223355__F9 Model of PLB1 transcriptional activation upon loss of Ypk1 or upon disruption to sphingolipid biosynthesis through treatment with myriocin PLB1 PC ORM2 ORM1 PMC2570214__F8 Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM TSC2 EGF TSC1 RHEB PMC5472757__F9 DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity CGAS TREX1 IRF3 PMC5405080__F9 Functional p53 control of cell growth and oxidative metabolism TIGAR MDM2 MTOR PMC8561620__F5 Regulatory effect between HMGA2 and the Wnt/Beta-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma HMGA2 LRP5 CCND1 LRP6 CDK4 PMC9583502__F2 Review on the role of cyclin dependent kinases in cancers COX2 VASP MEI1 MMP2 CDK2 SMYD2 ARHGAP24 HIF1A STAT3 PMC6012981__F5 Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes IRF8 JAG2 PMC5462521__F1 YAP protein interaction, activation, and inactivation within the canonical Hippo Pathway NF2 LATS1 PMC9549360__F4 Regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface YTHDF2 STAT1 YTHDF1 TLR4 METTL3 NOD1 MTOR IGF2BP2 DDIT4 SOCS1 PMC4123224__F6 Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis CXCR4 MYD88 TLR1 PMC7290655__F6 In PI3K-Akt signaling pathway (KEGG ID: hsa04151), various PKs and PPCPs are involved in translating the extracellular stimuli into phosphorylation signals and propagating these signals into downstream pathways PIK3R1 BAD HEL2 SFN HEL-S-1 CDKN1B EGFR GSK3B TBC1D4 IRS1 INSR TSC2 FGFR1 GRB2 RAF1 HEL-S-93 YWHAG SHC1 PMC11758792__F1 Lung TME chip operation principles IL6 IFNG PMC5429325__F1 Action of branch‐chained amino acids (BCAAs) POMC MTOR SIRT1 PMC4002662__F2 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling TRAF5 TRAF1 RELA EGFR TRAF6 TRAF2 PMC4002662__F1 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling TRAF5 TRAF1 RELA EGFR TRAF3 LTB RELB TRAF6 PTEN MTOR TRAF2 PMC6533679__F12 Schematic representation of the underlying mechanism of miR-137 in CC GREM1 SMAD2 CDH2 PMC8650160__F2 RAD52: Paradigm of Synthetic Lethality and New Developments RIF1 FANCD2 SLX4 HLTF RAD52 SMARCAL1 RAD51 PCNA ATAD5 PMC4939482__F3 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure MMP2 MMP9 ATR ACE2 PMC8773762__F2 Adipose Triglyceride Lipase in Hepatic Physiology and Pathophysiology EGR1 SP1 SIRT1 PMC4388523__F4 Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells ALAS1 HBA2 FECH UROD HBE1 UROS HMBS CPOX ALAS2 HBZ PMC4939482__F1 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure ACE2 PMC4977324__F2 Influence diagram of contains partial prior biological knowledge and epigenetic information in the form of methylation and histone modification LEF1 MYC DACT2 DACT3 CD44 CCND1 SFRP1 DKK1 DKK2 DKK4 TCF4 PMC9616080__F2 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response STAT1 JAK1 TSLP STAT3 PMC9616080__F3 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response DAZAP2 SMURF2 TRAF6 IL17RB TRAF4 PMC4977324__F4 Influence diagram of is a naive Bayes model that contains minimal prior biological knowledge SFRP4 LEF1 MYC DACT2 DACT3 CD44 CCND1 SFRP1 DKK1 DKK2 DACT1 DKK4 PMC9616080__F4 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response IRAK1 IL1RL1 IL33 TRAF6 IRAK4 MYD88 PMC8551477__F4 Insulin action at a molecular level – 100 years of progress GCGR PDE3B GRB2 INS DDT TG CBL PMC8551477__F5 Insulin action at a molecular level – 100 years of progress PDX1 PI3 INS GCK CRTC2 OTOS TCF2 FOXO1 INSR FOXA2 PMC2937064__F1 Leptin, IGFBP3, and rapamycin suppress the IGF-1 signaling pathway to preserve naïve T cells and promote longevity CD27 IGF1 MTOR STAT3 PMC7102884__F1 Exhibits the involvement of transduction pathway in AML CXCR4 CXCL12 MTOR PMC2937064__F3 CD28 signaling pathway in T cells is equivalent to the IGF-1 pathway in the whole organism IGF1R FOXO3A FOXO1 PMC8750552__F7 Ginsenoside Rg3 Attenuates TNF-Alpha-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms BCL2 SIRT1 BAX SIRT3 PMC2937064__F4 Reactive oxygen species, UV light or other genotoxic stresses, that induce DNA damage, principally, double-stranded breaks, is detected by the MRE11-RAD50-NBS1 complex, which in turn activates ATM IGF1 ATM XPC MTOR BAX PMC6375051__F2 Mitophagy links oxidative stress conditions and neurodegenerative diseases PINK1 PMC5297661__F6 Protein association networks UBE3A BACE1 UBE2D1 ADAM9 UBE2D3 HSP90AB1 PSEN2 HSPA2 MAPK14 PTEN UBE2E2 TMED10 UBB UBE2E1 UBE2A MAPK12 UBE2V2 MAPK1 PSENEN ECE1 HSPA4 CAMK2A PMC8491233__F2 Mitochondria as a target in cancer treatment FH EGFR PTEN PMC11170970__F6 SH alleviates DSS‐induced colitis via the “SH‐gut microbiota‐5HIAA‐AhR axis AHR IL6 IL1B PMC5584301__F2 SETBP1 dysregulation in congenital disorders and myeloid neoplasms SETBP1 MYB SET PMC7129598__F1 General overview of disease progression GC TNF IL1B ADAM17 PMC3882141__F1 Regulatory Networks and Complex Interactions between the Insulin and Angiotensin II Signalling Systems: Models and Implications for Hypertension and Diabetes TSC2 TSC1 PDK2 PTEN MTOR RHEB PMC6213971__F3 Regulation of PTPIP51 in melanoma BRAF LYN FLT3 PMC8530550__F1 Artificial immune synapse with an introduced DNA-based mechanics-controlling module APC LCK ZAP70 PMC8194072__F1 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration EGF CXCR4 RHO MTOR PMC7484613__F1 Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6 IL6 IL1B TET2 PMC8194072__F3 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration CXCR4 MSC IVD PMC2724029__F4 Signaling networks upregulated in migrating neuroblasts KCNMB4 HERC1 WASF1 VCAN CRIPT PMC9255247__F2 Prostate cancer stem-like cells in the development of antiandrogen resistance APC RELA SMO PMC2724029__F5 Signaling networks upregulated in migrating neuroblasts ARHGEF7 MAP2K4 KALRN ATF2 UNK MAP3K13 DIXDC1 MCF2L KLHL2 TRIO VAV2 PMC12045949__F1 Molecular Mechanisms Underlying ALKBH5-Mediated Regulation of Hepatic Glucose and Lipid Metabolism GCGR EGFR ALKBH5 MTOR FASN PMC8427323__F1 Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells IMPACT CYC1 MAL PMC9019265__F1 Statins and endocrine resistance in breast cancer RHO RAB27B MTOR PMC6854496__F1 RIG-I-like receptor (RLR) activation by various RNAs during DNA virus infection TBK1 MRPL18 IRF7 IRF3 MAVS DUSP11 PMC5511499__F4 How is the Brain Renin-Angiotensin System Regulated? LRP5 PMC8387362__F1 Study workflow PALB2 NCOR1 ATM BRCA2 PTEN BRDT ERCC2 BRCA1 PMC3613369__F3 Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines PTGER2 AKAP12 MAFB AQP1 RGS4 Nbla10317 FGF8 DKK1 COLEC12 CCND2 EFS BEX4 TNFSF6 CPA4 FGF19 HEL113 NTRK2 CD36 PMC9110257__F9 LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells CASP3 LARS2 MFN2 PMC1592599__F1 TNFA signaling pathway leading to apoptosis or proliferation of the cells TRADD TNF TRAF2 FADD PMC4394389__F8 Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom CSK ARHA MAL PMC9247951__F2 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance DLX2 HGF opn SRC PROX1 WIF1 NRP2 PAX8 GATA2 PMC6952997__F8 Influence of ethylene on amount of compounds and expression of genes in lipid pathway in peach PC PGP LPA PSD CP PEMT PMC5746035__F3 Oncogenic regulation of glucose flux into PPP TIGAR F2 CDK6 PMC7564365__F6 Pilot Study on MicroRNA Profile in Tear Fluid to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema COX2 BAD SMAD2 ENG SMAD1 RAI1 PMC5746035__F1 The glycolysis and pentose phosphate pathways (PPP) are tightly connected TIGAR F2 FBP1 HEL-S-5 PMC6152083__F10 Part of the PPAR signal pathway OLR1 AQP7 LPL EHHADH CD36 PMC4709516__F3 The Dendrobium catenatum Lindl. genome sequence provides insights into polysaccharide synthase, floral development and adaptive evolution FRK GAL PMC8982327__F5 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin SMAD2 SMAD4 PTEN PMC5818366__F1 “cross-talk” between liver and peripheral organs in the pathogenesis of NAFLD PNPLA3 POMC NPY AgRP PMC8982327__F1 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin SMAD2 SMAD4 MTOR PMC5998384__F3 Metabolic PathwaysCell-cycle effect on the stability of protein components of the pentose phosphate pathway (PPP) HEL107 HEL-S-5 PMC11740669__F1 Autophagy negatively regulates pyroptosis pathway NLRP3 ULK1 MARCHF7 IRGM LGALS9 RALB PTEN MTOR MIB2 PTPN22 GSDMD USP18 PMC9247951__F3 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance NR3A2 EGFR TGFBR2 CREB1 ITGA7 ESRRA NRP2 NR2F2 PLXNB1 PLXND1 SRC MAPK1 SEMA3C SNCA CHL1 VEGFA NRCAM SEMA3B ITGB1 CASP3 VEGFC CANX COX16 NXPH2 NRP1 ARL6IP5 SEMA3E PLXNA1 PLXNA3 BCL2 PCDHGB1 ESYT1 SEMA3G STAT3 PMC3823093__F4 Network analysis of proteomics using IPA ZNF71 OXCT1 ADAMTS9 PROX2 MFHAS1 MYC DLD NDUFS3 TNNI3 H1-1 ERBB2 SUSD2 MYH13 UQCR10 KRT9 MYH8 SRP19 PMC6068015__F1 Lymphoma immune evasion mechanisms CD58 SIRPA CD47 HLA-G CD2 CCR4 CD80 LAG3 PMC3520045__F4 Summary diagram of Nrf2 and HIF1 stimulation in presence of oxidative stress EPO KEAP1 VHL HEL-S-44 PMC11740669__F6 LMP with STAT3 signaling pathway promotes pyroptosis and ferroptosis NLRP3 CGAS HEL-S-130P GSDMD STAT3 DFNA5 PMC6731416__F9 Proposed model for the roles of Wnt/Beta-catenin signaling regulated by quercetin in protection of BBB breakdown LEF1 GSK3B PMC11740669__F2 Ferritinophagy regulatory network influences ferroptosis sensitivity HERC2 MTF1 TFEB KEAP1 ATM FTH1 FTL MTOR VAMP8 FBXL5 PMC11740669__F3 Mitophagy resists two forms of cell death NLRP3 PINK1 ULK1 GPX4 TFEB FUNDC1 BNIP3 MTOR GSDMD BAX DFNA5 PMC11740669__F5 Innate immune system regulates two types of ICD through autophagy TBK1 NLRP3 CGAS GPX4 TLR4 POLG LATS1 MYD88 GSDMD PMC6326181__F7 Integrative Modeling of Cancer-Type-Specific Hippo Regulatory Networks IGF1R EGFR SMAD4 TEAD4 PTEN LATS1 RB1 MOB1A MOBKL1A CDKN2A LATS2 TAOK1 TEAD2 TAOK2 TEAD3 HEL-S-26 ATM NF2 CIC WWC1 SOX2 RNF43 YAP1 TAOK3 APC ARID1A ZNF217 ERBB2 STK4 MCL1 IKZF2 FRMD6 PMC3823158__F1 Canonical NFKB signalling pathway BCL10 TRADD TRAF2 PMC5209488__F6 Summary of the mechanism of Dicer regulation in osteogenesis RUNX2 APC PTEN PMC2493210__F1 Schematic diagrams of small intestine mucosa in normal and infected intestines TLR4 BPI NOD2 PMC7848146__F2 Signaling pathway and mechanism related to lung cancer driver gene in brain metastasis PTEN MTOR PMC1797319__F1 Shewanella oneidensis MR-1 anaerobic carbon metabolism pathway CIT MAL PMC6770221__F6 Mechanism of optimal therapeutic drugs in each subtype of breast cancer KDR BRAF ABO RAF1 JUN PMC5381176__F8 MiR-93 activates the PI3K/Akt pathway by targeting LKB1/PTEN/p21 TSC2 TSC1 EGFR PTEN MTOR PMC3394417__F1 Sample gene regulatory network RALBP1 PMC5203625__F3 Selected metabolic pathways of the putative novel SAOB unFirm02_FrBGR cluster 2 FES HEL-S-5 PMC7369933__F3 One-carbon metabolism, DNA/histone methylation, and drug interaction VIT MTHFD1 PMC7493015__F7 Epithelial repair mediated by LXA4 in bronchial epithelium P2RY11 FPR2 PANX1 PMC7493015__F3 Arachidonic acid (AA) metabolome and abnormal class switching in CF COX2 COX1 PMC8849533__F8 Working model of the role of CNTN1 in the regulation of MAVS-mediated signaling and influenza A virus replication TBK1 CNTN1 IRF3 USP25 MAVS PMC7493015__F5 Ion transport regulation by LXA4 and RvD1 enabling the restoration of ASL height in CF human bronchial epithelial cells P2RY11 FPR2 PANX1 ASL PMC6102449__F6 Working pathway for Er-Miao-Fang inhibiting inflammation and blocking hepatic gluconeogenesis PDE3B PDE4B IL1B PMC2899872__F1 Sequence Comparison Suggests a Role for TTL in Allantoin Biosynthesis.(A) Alignment of TTL with Urad and Urah protein from zebrafish TTL URAD PMC9367608__F1 Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma GOT2 HEL-S-133P HK2 FASN PMC3182268__F1 Apoptotic pathway to cell death from the perspective of the Bcl-2 family of proteins.1, The intrinsic pathway is initiated by various signals, principally extracellular stimuli BAD BAX PMC8830542__F1 Nevi, dysplastic nevi, and melanoma: Molecular and immune mechanisms involving the progression POMC BRAF MC1R PTEN PMC5562214__F7 Cardioprotective effects of macitentan SIRT2 LARS2 PTGIS PON1 WFS1 HEL-S-130P STAT1 SERPINC1 PPP1R3A COX6A2 SERPIND1 MLYCD XDH TRIM72 SGCB CSPG4 CD36 APPL1 PMC6391848__F4 Enrichment analysis of differentially expressed mRNAs PROC RB1 PMC8492658__F1 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients PLCB4 HEL-S-2a PTGER2 COX2 PTGIS COX1 XDH PMC8492658__F6 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients AGTR1 APLN ACE2 PMC9147606__F2 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease NLRP3 TLR7 TLR4 TLR9 MPO REL IL1B TF PMC4716080__F1 Wnt-Beta-catenin signaling pathway APC LRP5 CD44 LRP6 PMC3789714__F1 Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens TSC2 ULK1 TSC1 MTOR PMC5477782__F8 The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation HMGB1 HP CD163 PMC6084451__F1 Host-Intrinsic Interferon Status in Infection and Immunity STAT1 STAT2 IRF9 IRF3 MAVS PMC5825896__F9 Schema of the anti-HIV mechanism of toll-like receptor 3 (TLR3) signaling of intestinal epithelial cells (IECs) ISG15 CCR5 IRF7 IRF3 MIP TLR3 PMC9147606__F3 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease MPO TF PMC2648516__F1 SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification MED12 POP1 MED1 SYS1 PMC4052347__F5 PPI network and signaling pathway analysis MAPK9 HDAC3 MAPK8 HDAC10 NFATC1 FOS HDAC8 BOP1 HDAC7 MAPK3 GSTM1 MAPK14 CASP3 NFKBIB CREBBP RBBP7 PPARG JUN PMC6056651__F7 Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development ARID4B ATF7 GOLGA2 ADPRHL1 ACYP1 SMUG1 CAMKMT PAX2 USP21 HOXB1 INO80C PAXIP1 KLHDC10 KLHL29 PHF12 IBTK NOL11 LAS1L IGF2BP2 FXYD2 INTS11 ASH2L ZNF644 RBM34 PLEKHG4 MSL3 SYMPK SLC47A2 PAX5 WIZ WDR18 ETNPPL TCN1 BACC1 PABPC1L ATXN10 COG3 EIF4E3 ANGPT2 AOC2 CDCP1 ARHGEF11 CDKAL1 MTR CYP2C9 MGA MTHFD2L ZBTB7B CTCF PAIP1 ACSS3 SSU72 ACOT12 EIF2AK1 SLC22A2 ACSM5 ALDH7A1 EYA1 CARNS1 CUBN HEL162 GLYCTK RUNX1 MAFF SIN3B SLC30A8 DDX3X AMN DDIT3 SUPT6H PABPC4 ADHFE1 PABPC5 OSBPL1A PKNOX1 MTRR EIF2AK4 CR2 SETD2 E2F6 PAPOLG DCSTAMP EIF2AK2 RILP ATF5 CFDP1 RBBP6 WDR33 FOSB CYP4A22 KDM2A COG6 COG5 RUNX3 GOLGB1 PCDH8 NRCAM SPTB KMT2C KMT2A PAN3 TNFRSF8 DHX30 SMOX CHD8 FOXN2 MLL2 RUNX2 SQSTM1 JDP2 ATF4 LDB2 PHF20 EIF4B HAND2 GATA3 NFATC1 NFE2L2 MMAA SMAD6 MMACHC PBX1 SPTBN2 IL33 DAB2IP MTHFS ARID4A ANO10 PMC11583782__F1 Predicted pathway and gene network in the treatment of AD with Jiawei Qifuyin PPP3CA GSK3B MAOA ALOX5 DRD1 IFNG CASP9 GABRA2 CHRM2 NOS2 ADRB1 GSTM1 ADRB2 GRIA2 CHRNA2 RXRA SLC6A3 CHRM1 BCL2 ADRA1A HTR2A TGFB1 MAP2K4 CHRNA7 HSP90AB1 ACHE CYP1A2 CHRM5 CACNA1S GABRB3 F2 CYP1A1 IL1B JUN SELE BAX PRSS1 OPRM1 ADRA2C PTGS2 RXRG PSMD3 CASP3 CHRM4 NFKBIA CHRM3 CYP3A4 RELA PPARG PMC7914934__F2 Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications SRI PPP5C GM2A HSPB2 WEE1 CDCA7 ABCC9 FARSB HEL-S-134P F7 CNBP BLK PMC6524659__F2 Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets IFIT3 PML IFIT2 BAD TRADD TRIM21 RELB MTOR SP100 RNASEL NLRP3 ISG15 RNASE1 TLR7 EIF2A CASP9 NOS2 IRF-1 CXCL11 BAX RSAD2 STAT2 IRF7 RBCK1 IRF9 CXCL10 IRF3 TNF TRIM25 IFI27 TLR3 ADAR CASP3 TSC2 TSC1 TNFSF10 TYK2 JAK1 TRAF2 MAVS IFI6 PMC3048558__F7 Proposed mechanism of gene regulation in response to extracellular and intracellular dsRNA stimulation RELA RELB TLR3 PMC9005749__F2 CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy GRB2 TIGIT CD226 PMC5771804__F4 GD T cells in homeostasis and host defence of epithelial barrier tissues CXCL9 MYD88 PMC11574213__F3 New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease MAF GPX4 KEAP1 SLC7A11 TNF NQO1 TERT STAT3 PMC1350949__F7 Proposed model of the HCMV-induced apoptotic signaling pathways CASP3 ATM CASP9 ATR BAX PMC7774741__F1 Flow chart for selecting SNPs in retinol metabolism pathway genes MAF ALDH1A3 HEL-S-53e PMC8037152__F1 Leukemic microenvironment supports survival of acute lymphoblastic leukemia (ALL) cells and their immune evasion through multiple interactions CD47 CXCR4 MSC CD200 CXCL12 PMC8043392__F11 Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury APC RYK AXIN2 PMC5738696__F1 IGF1R signaling pathway and its relevant drug resistance mechanisms: Promoting proliferation, inhibiting apoptosis and inducing changes to ABC transporter proteins and the ECM IGF1R IGF1 IGF2 MDM2 IGFBP7 GRB2 SP1 WT1 IRS1 BAX PMC2639705__F9 Two Chromogranin A-Derived Peptides Induce Calcium Entry in Human Neutrophils by Calmodulin-Regulated Calcium Independent Phospholipase A2 GC CGA PMC7754042__F7 miR‐218 could inhibit OSCC proliferation, migration, invasion, EMT and liver metastasis through the TGF‐B signalling pathway by regulating GREM1 GREM1 SMAD4 PMC8353397__F10 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis LTA NGF TRADD ZAP70 HDAC2 HDAC1 PMC9093074__F2 Dual-Targeted Therapy Circumvents Non-Genetic Drug Resistance to Targeted Therapy WEE1 ATM SRC CDC2 ATR PMC6989439__F2 Cellular-mediated rejection SLA SIRPA CD47 APC PMC6989439__F3 Coagulation cascade related to xenotransplantation PC TFPI APC VWF TF PMC8945550__F1 Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution AIP HMBS PMC6888641__F1 PI3K/mTOR signaling cascade ULK1 BAD DEPDC5 MYC PTEN RHEB CCND2 TSC2 TSC1 MDM2 BCL2 CDC2 JUN PMC11174581__F1 Promotion mechanisms of microecologics on sports performance CORT UCP1 TGFA WNT10B SIRT1 PMC8853618__F14 SPOCK1 Promotes the Development of Hepatocellular Carcinoma EGFR SRC CDK4 SPOCK1 PMC3005023__F1 Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis TCF3 EPO ANGPTL4 HEL-S-30 IGF2 VEGFA VHL IL6 PFKL RBX1 HEL-S-130P HEL-S-68p HEL-S-162eP ANGPT1 TWIST1 FGF3 IGFBP1 CXCR4 ZEB2 NOTCH1 NOS2 TGFA HEL-S-133P ADM PMC1876599__F3 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR SUMO2 PELP1 GPT FHL2 GRB2 HDAC2 RAF1 BCAS2 STAT3 PMC8126563__F3 Protein kinase CK2: a potential therapeutic target for diverse human diseases SET SKP1 KNS2 PMC3714263__F6 ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells ME1 PLCG1 ITK FYN ME2 CD33 LCK VAV1 GRB2 LAT NCK1 PMC8126563__F1 Protein kinase CK2: a potential therapeutic target for diverse human diseases MDC1 PTEN MRE11A STAT3 PMC8126563__F2 Protein kinase CK2: a potential therapeutic target for diverse human diseases PML EIF2A MDM2 ARC CDC37 ABCG2 PMC8091781__F10 COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/Beta-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells NEDD9 BIRC5 APC GSK3B CCND1 PMC3708893__F5 Oral Neutrophil Transcriptome Changes Result in a Pro-Survival Phenotype in Periodontal Diseases TBK1 TRADD SKI DIABLO TRAF2 HTRA2 FADD PMC7183876__F2 MiR-21 and miR-17~92 promote cyst growth PKD1 MTOR NR1C1 PMC4510836__F1 Complement cascade and its regulators HEL-S-62p CD59 C9 CD46 FH C7 C6 CR1 PMC4510836__F2 Complement activation on allograft injury APC CD80 CR2 CAD IFNG PMC8935220__SF1 Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2 MAF KEAP1 NQO1 PMC12121617__F7 BNC1 acts on the CCL20 promoter to suppress the expression of CCL20 in GC cells BNC1 CCR6 CCL20 STAT3 BAX PMC7590238__F1 ICL repair pathway at different cell cycle phases REV1 FAN1 FANCD2 SLX4 EME1 XPC XPA PMC6417502__F8 Collagen upregulates MMP-14 through activation of the TGFB/TBRI/Smad3/Snail pathway EGR1 SRC PMC7461207__F3 Mechanotransduction signalling for osteogenesis of human mesenchymal stem cells (hMSCs) TRPV4 RUNX2 BMP2 FOS SMAD1 PMC10816924__F7 KLF10 in cardiac fibrosis IL9 KLF10 BCL2 HDAC1 PTTG1 BAX PMC3883721__F1 Phosphoinositide-3 kinase (PI3K) is a heterodimer consisting of p85 and p110 subunits TSC2 TSC1 MTOR PMC4359534__F7 Cardiovascular disease, lipid metabolism, molecular transport DBI BMP3 INSIG1 LIPG EMP1 PMC7542480__F4 Protein-protein interaction network CYP2C19 HSD11B1 GSTM1 NR1C2 XDH PRDX5 PARG TNF PLA2G2A PDPK1 RXRA PMC4359534__F8 Cell-cell signaling and interaction, molecular transport, small molecular biochemistry AOAH LMX1A NEDD9 ADRB1 NTS UCP3 PMC6332742__F1 The central role of C1 inhibitor in various plasma systems., Upon contact with negatively charged surfaces factor XII (FXII) is (auto‐) activated to activated factor XIIa (FXIIa) PLG C1S PMC2728144__F6 Schematic diagram depicting our findings on the post-transcriptional regulation of CXCR4 in MCF7-HER2 cells as a result of estrogen and HER2 cross-talk and the involvement of activated PI3K and MAPK pathways and TSC2 (tuberin) TSC2 PI3 CXCR4 EIF4E MTOR PMC8894804__F1 ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions RPS6KB1 NCOR1 KEAP1 FUNDC1 PMC5362561__F1 Scheme of the metabolic pathway of purines and their relation to hypoxanthine-guanine-phosphoribosyltransferase (HPRT) ADSL ADA PNP PMC8885406__F3 XPO1 mediated emergent drug resistance pathways SET TOP2A PMC4991833__F4 Simplified model for the symbiotic signaling pathway in legumes NUP133 NUP85 PMC4391565__F10 H3K56 acetylation prevents genomic instability by affecting Ctf4 function MCM3 MCM5 MCM6 POLE MCM2 MCM7 PMC7787056__F4 Duality of human oncoproteins: drivers of cancer and congenital disorders KIT RET ALK EGFR PMC7108731__F1 Influence of rare variants in circulating metabolic biomarkers PDPR PDK2 PDP2 PMC6302517__F3 Schematic illustrating the role of cav-1 in different cell TLR4 MYD88 PMC7326806__F5 Reciprocal regulation between brain cancer and neuronal cells in the brain HEL-S-11 NLGN3 APP SMAD4 ADAM10 PMC4694672__F7 Silk + bLf NPs induced apoptosis in EGFR +ve and EGFR −ve cells.Notes: Internalization of both forms of nanoformulation was facilitated via LRP1 receptors and EGFR in MDA-MB-231 cells and via death receptors in MCF-7 cells NPS EGFR BAX PMC7326806__F3 Overlapping molecules in cancer and neurodegenerative diseases PIN1 CDK2 GSK3B APP CCND1 NQO1 BAX PMC8032583__F1 Serum 4Beta-hydroxycholesterol increases during fluconazole treatment SQLE DHCR24 CYP51A1 PMC4664252__F9 Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade CCL5 CCL4 CCL2 IFI16 CCL3 PMC7145987__F4 DNA damage response defects in high risk neuroblastoma (HR-NB) MAX ATM BLM ATR H2AX CHEK1 MRE11A AURKB PMC8360618__F3 MUC1 is an oncoprotein with a significant role in apoptosis (Review) MUC1 MEI1 FADD BAX PMC4600855__F1 S-nitrosylation in TRAIL/DR4 and FaL/Fas signaling pathways CASP3 CASP9 YY1 CASP8 FADD PMC7593679__F1 TRP and its key catabolites (TRYCATs) produced via three biochemical pathways: the kynurenine pathway, tryptamine pathway, and serotonin pathway IDO1 TPH1 KMO IDO2 TDO2 PMC4600855__F2 S-nitrosylation in classical TNF-NF-kB signaling TRADD SHARPIN TRAF2 CASP8 FADD PMC2435380__F1 Methionine metabolic pathway HEL-S-61p HEL-S-182mP PMC4600855__F3 S-nitrosylation in TNF-JNK-AP-1 signaling TRADD FOS TRAF2 PMC8526538__F8 Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy LAPTM5 RAC1 PRAC1 PMC5995375__F8 Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting VCAM1 TNF SELE PMC11039397__F7 Mechanism diagram of SR1 alleviating bone lossIn the natural environment, air pollutants contain different AhR ligands AIP CTSK AHRR AHR NFATC1 DCSTAMP TRAF6 ACP5 ATP6V0D2 PMC8555053__F4 On the role of dauer in the adaptation of nematodes to a parasitic lifestyle IGF1 PPM2C SGK1 NCR1 PMC7400736__F3 Interaction network of the let-7 family targeting the IGF family members generated from HMDD version 3 CRX IGF1R F2R DKFZp781B1423 BCL2L1 IKZF3 AP1S1 ARG2 MDM2 CCND1 EN1 EPHA4 IL13 TES IGF2 ACTA1 FXN ARID1A CASP3 EDN1 IGF1 CDKN1A CCNG1 BTG1 MYBPC3 BCL2 MPL PMC11923913__F7 Cellular mechanisms, signaling pathways, and potential therapeutic targets in TRALI HMGB1 CXCR4 CD40 ROBO4 PMC7400736__F4 Crosstalk between the insulin/IGF signalling pathways and the potential targeting of let-7 RLN2 RLN3 IGF2 INS IGFBP5 INSR IGF1 IGFBP1 IGFBP4 IGFBP2 PAPPA2 IGFBP6 INSL6 RLN1 INS-IGF2 INSL5 PMC7150862__F8 Schematic model of miR-202-5p-mediated RIG-I-like receptors (RLRs) signaling pathway during viral infection TBK1 TRAF3 TRAF6 IRF3 TRIM25 MAVS PMC514698__F1 Known Yeast Cell Cycle Interactions CDC20 CDC6 CLN3 PMC4286601__F1 Main glucose degradation pathways in the heart HEL107 HEL-S-162eP PMC6193168__F5 Involvement of mitophagy in the transportation of amorphous calcium phosphate (ACP) precursors from the mitochondria to the extracellular matrix in stem cells with osteogenic potential PINK1 RUNX2 BMP2 LAMP2 SMAD4 SMURF1 SMAD1 DKFZp781O1323 PMC5045388__F4 Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer EDN1 MTOR ARAF PMC7993678__F6 Cancer associated fibroblasts (CAFs) from osimertinib-resistant patients promoted osimertinib resistance via HGF/MET signaling and induction of epithelial-to-mesenchymal transition (EMT) and transformed NSCLC cells into TKI resistant stem-like cells HGF EGFR PMC5852508__F6 Proposed central and peripheral pathways/mechanisms being activated by circulating Ang II and high dietary salt intake AVP NTS PMC11923913__F5 Signaling pathways in TRALI HMGB1 TLR4 CXCR4 CD40 ROBO4 CXCL12 SLIT2 MTOR PMC3322580__F4 Enrichment and submodularization of cell cycle in terms of E3-mediated regulatory modules CD14 SNCA CDC20 SCT MDM2 RAD21 PCNA PMC11923913__F6 TRALI‐targeting therapies HMGB1 TLR4 CXCR4 CD40 MR1 MTOR PMC2974215__F2 TNF-dependent signalling pathways mediated through TNFR1 and TNFR2 TRADD TNF TRAF2 FADD PMC10518396__F7 Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt’s lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib BTK BCR EZH2 PMC4086337__F1 NLRP3 inflammasome regulates the caspase-1 dependent maturation and secretion of pro-inflammatory cytokines NLRP3 TLR4 IL1B PMC3377094__F2 Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins TBK1 TLR9 IRF7 IRF8 TRIM21 TRAF6 IRF3 MYD88 TLR3 TRIM23 TLR7 TLR4 RELA TRIM27 TIRAP TAB3 PMC11673339__F5 Search for pathways that reflect gene expression effects of Semax and ACTH(6–9)PGP at 24 h after tMCAO in FC EGR1 P4HA2 EGR2 FOS EGFR SPHK1 JUNB TNF NAGS PMC3170448__F5 Simply comparing and contrasting the expression patterns of perturbed genes was inadequate for deciphering the MAPK pathway response dynamics MAP2 DUSP14 TRO HEL-S-93 FGF7 PMC6287148__F1 Mitogen-activated protein kinase pathway BRAF EGFR GRB2 PMC6036835__F5 KEGG pathway (FDR < 0.05) enriched by the 289 differentially expressed genes in drug group compared to model group CACNG7 MRPL2 RPL37 COX6B2 MRPL27 COXFA4 ATP6V1C1 COX7A2 RPS15A RPL34 PMC4461477__F5 Emerging molecular machinery and therapeutic targets of metastasis MMP2 VCAM1 PMC1958996__F2 Transcriptional control of adipocyte formation E2F4 CDK4 PMC11889691__S1 Multiscale mechanical-adapted hydrogel for the repair of IVDD MMP3 COX2 MMP9 IVD PMC8220440__F2 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations TRADD EBP LIF TNF IL1B PMC11677934__F8 Essential Role of Cortactin in Myogenic Differentiation: Regulating Actin Dynamics and Myocardin-Related Transcription Factor A-Serum Response Factor (MRTFA-SRF) Signaling YAP1 PMC8220440__F3 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations TRAF1 TRAF3 TNF TRAF2 PMC9661523__F4 Non-cardiomyocytes in the heart in embryo development, health, and disease, a single-cell perspective CDH11 NFATC1 CX3CL1 EFNB2 PDPN PROX1 IL6 CCL2 HEL-S-104 FBLN5 RSPO3 NPR3 RGCC TBX1 DLL4 SMOC1 CA4 NTRK2 SEMA3G CD36 PMC6527283__F2 Interaction of tumor-associated macrophages and cancer chemotherapy CD80 STAT3 PMC2213208__F1 Activation of the vagus nerve leads to the release of acetylcholine (Ach) that binds to Alpha-7 nicotinic receptors (A7 nAChR) on cytokine producing cells HMGB1 SOCS3 TNF STAT3 PMC9493050__F7 Calcium dobesilate efficiency in the treatment of diabetic kidney disease through suppressing MAPK and chemokine signaling pathways based on clinical evaluation and network pharmacology CASP3 TRADD GRB2 SRC CCL5 RAF1 HRAS TRAF2 JUN AKT3 PMC2860555__F1 Endosomal and cytoplasmic pathways for virus recognition and IFN production TBK1 TLR8 TLR7 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 TLR3 MAVS PMC9693603__F11 Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan MMP9 BCL2 STAT3 BAX PMC8668986__F10 Metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer TYK2 STAT3 PMC5496137__F1 Central metabolic pathways of E HBD CIT PMC4726471__F2 Interplay Between Centrosomes and the Hippo Tumor Suppressor Pathway MDM2 LATS1 LATS2 PMC5700047__F8 Proposed model of CHK1 as a facilitator of transformation and drug target MYC BCL2 BAX PMC11019653__F7 Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action PTGS2 MDM2 PMC11354767__F6 GPR30 signaling pathway EGFR GRB2 SRC HBEGF STAT3 PMC3466049__F1 Complement-targeted therapeutics in periodontitis CD14 TLR4 CXCR4 GSK3B RAC1 TLR1 IRF-1 IFNG PMC4359534__F9 Lipid metabolism, molecular transport, small molecule biochemistry CRHR2 CALCA CUBN MYL1 FOSB GATA6 AMN HTR2B DKFZp761E1322 PMC2761008__F2 Minimum spanning tree of the network associated with cancer pathway genes PIG59 ID4 MGLL SMAD2 TGFBR1 SOX4 RPL31 CCNI TBP ATM NGFR MT2A GHR APP PICALM RGS16 PRKAB2 RBL2 CCNE2 RUVBL2 SNCA ACTG2 SKIL MAFF NRCAM MAPRE2 HBEGF RGS2 CTSH UBE2B DDB2 HEL-S-130P CDK2 RELA KPNA2 GRB2 DGKZ BCL2 MST065 MEF2C PCNA MYLK PMC2761008__F3 Cliques or near cliques from the cancer pathway related network Gp ACTG2 RUNX2 ID4 SKIL FOS SMAD2 CSTB BCL2L1 RPL35A HEL-S-130P BGLAP RPL31 MCM3 DDX56 GIG8 ATM CDK2 HEL-S-2 CCNB2 GRB2 THBS1 TGFB1 MYLK RBL2 PMC6422174__F1 Linking Signaling and Selection in the Germinal Center FH CD40 IL-21 FOXO1 PMC11200706__F2 Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes DCT TYRP1 PMC3101816__F1 The central role of cIAP1 in NFKB signalling and programmed cell death CAP2 TRADD TRAF2 FADD PMC7133220__F9 Putative mechanisms by which neratinib down-regulates mutant K-RAS expression and inactivates Hippo Pathway function ATG16L1 ATM LATS1 LATS2 PMC5348443__F2 Kinase inhibitors as potential agents in the treatment of multiple myeloma RELA RELB CD40 PMC6386826__F1 Signaling transduction of mTOR pathway TSC2 RICTOR TSC1 MDM2 PTEN EIF4E MTOR CDKN2A SGK1 MLST8 PMC10476361__F6 HDAC5 regulates MEF2A expression by influencing the ERK/EGR1 signaling pathwayVentricular remodeling induces cytoplasm translocation of HDAC5 EGR1 HDAC5 PMC4437987__F1 Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors EGFR RPS6 MLST8 PMC5488651__F3 Bacterium Helicobacter pylori is a well-studied example of a pathogen manipulating host PAK1 signalling PAK1 TLR4 RAC1 IL1B PMC8476122__F2 Pembro enhances Gln uptake/release of glutaminolytic products while blocking Gln-fueled Krebs cycle activity in primary CA but not in NC lung tissues HEL-S-62p GLS PMC3442865__F1 TOR pathway activation EIF4E MTOR PMC4336822__F1 Progesterone action in breast, uterine, and ovarian cancers CDK2 HBD PMC8058565__F5 Sulfation of 25HC as an epigenetic regulatory pathway BAD CAV3 CREB1 CAV2 SIRT1 HMGCR PMC8917703__F2 Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation TBK1 CGAS P2RX7 CXCL10 APC HEL-S-99n IFNAR1 CXCR3 TLR4 P2RY2 VCAM1 RELA EZH2 CMTM4 PMC4355395__F4 The 12/15Lipoxygenase as an emerging therapeutic target for Alzheimer's disease CDK5 APP SP1 PMC4336822__F3 Progesterone action in breast, uterine, and ovarian cancers IHH IGF1 DKK1 HAND2 PMC6851227__F1 Metabolic alterations in AML blasts HEL-S-26 CS MTOR HEL-S-133P HK2 GLS PMC6503643__F2 HSVs modulate antiviral mechanisms related to cell death in non-immune cells EIF2A LAT BAX PMC6851227__F2 Enhanced tryptophan-turnover in AML blasts IDO1 AHR KMO MTOR PMC6503643__F4 HSV proteins modulate key steps in interferon-related pathways STAT1 CREBBP STAT2 IRF7 TRAF3 IRF3 JAK1 PMC6503643__F5 HSVs interfere with antiviral processes in innate immune cells TBK1 CGAS PIGT CD1D MICA TLR1 PMC9605425__F5 Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NFKB Pathway VCAM1 RELA CCL2 TNF PMC5482757__F4 Emerging Role of MicroRNAs in mTOR Signaling TSC2 TSC1 MDM2 DROSHA PTEN RHEB PMC4259450__F2 Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences TSC2 TSC1 CDK2 EGFR MYC MDM2 CDK4 PTEN CDC2 MTOR CDK6 PMC2695826__F2 Age-Related Decrease in Proteasome Expression Contributes to Defective NFKB Activation during Hepatic Ischemia/Reperfusion RAN GUSB PMC3772092__F7 Cadherin 6 Is a New RUNX2 Target in TGFB Signalling Pathway TNC SNAI1 CDH6 RUNX2 SNAI2 CDH16 HEL113 ID1 TF PMC5482757__F1 Emerging Role of MicroRNAs in mTOR Signaling TSC2 RICTOR TSC1 PTEN MTOR RHEB PMC7718880__F8 Schematic diagram illustrates the mechanism for the effect of the oxalate/LCN2/ERK and p-ERK and the expressions of LCN2, PTGS1, GPX3 and MMD axises on renal epithelial cell damage during kidney stone formation GPX3 MMD LCN2 PTGS1 PMC5482757__F2 Emerging Role of MicroRNAs in mTOR Signaling TSC2 TSC1 PTEN BDNF DDIT4 RHEB PMC2695826__F1 Ingenuity pathway analysis identified a network of genes down regulated in response to 60 minutes of ischemia in aged mouse liver FUBP1 ATF2 CCNH PMC4037130__F1 Targeting protein prenylation for cancer therapy TIAM1 TSC2 BAD TSC1 RIN1 MDM2 RHO RAC1 RHEB CDC42 PMC5482757__F3 Emerging Role of MicroRNAs in mTOR Signaling TSC2 TSC1 PTEN CAB39 BDNF DDIT4 RHEB PMC10870461__F16 Signal pathways related to CALD1 mapped by KEGG database PTGIR EDNRA AVP CNP ARHA CAD ADM PMC6676344__F2 Graphical summary of the anticancer mechanisms of formononetin IGF1R TIMP1 CDK2 ERG FGF2 CCND1 SRC PTEN FGFR2 EPHB3 STAT3 BAX PMC8292425__F1 Sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle DGAT1 DGAT2 SCD MGAT2 PMC7851265__F3 rTSMS regulates functional protein synthesis and pathways MOG MBP HEL-S-99n NME2 PRDX3 HEL-S-2a HEL-S-94n HEL-S-67p ANXA2 HEL-S-44 HEL-117 RHOB SDHB STMN4 NCDN GSTM1 BASP1 RAC1 SLC25A4 THY1 PS1TP5BP1 HEL-S-69p ARHG PCSK1 CDC42 PMC6551881__F8 Over-expression of miR-195-5p blocks the PSAT1-mediated GSK3B/Beta-catenin signaling pathway, thus inhibiting angiogenesis and reducing chemotherapy resistance to DDP PSAT1 GSK3B PMC8308291__F1 Omega-3 Supplementation and Heart Disease: A Population-Based Diet by Gene Analysis of Clinical Trial Outcomes FADS2 ELOVL5 ADA FADS1 ELOVL2 GLA HEL-S-5 PMC9554963__F1 Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways EGFR EIF2A MYC PMC3343318__F6 PLC signaling in B cells BTK TLR4 BCR BASH LYN SYK MYD88 RYR3 STIM1 TIRAP PMC8364365__F5 Crucial Roles of Intermediate Metabolites in Cancer KYNU AHR KMO AFMID PMC8273223__F1 Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play GSTT1 MPO CYP3A4 HEL-S-22 PMC8014161__F11 Network Meta‐Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID‐19 Pathologies HMGB1 IGF1 CDK5 UNK PTEN LAT AMT STAT3 PMC5697091__F7 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S CD14 CTSK TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR3 CPO PDC IL16 TLR4 LBP CD40 CD80 FADD TIRAP PMC9305664__F2 Non-Coding RNAs in Primary Biliary Cholangitis PDC TGIF2 SMAD2 TBR1 TNF PMC5697091__F8 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S CD14 CTSK TLR9 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TNF TLR3 CPO TLR4 LBP CD40 CD80 FADD TIRAP PMC5697091__F9 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C HEL-S-62p F10 TFPI CS PLG F8 F9 DAP CPB2 C9 PC A2M F2 FH F3 C7 VWF F7 C6 CR2 PMC7285805__F1 STAT6 modulates pro-colitis and pro-cancer responses PMC7285805__F2 Targeting the IL-4/IL-13/STAT6 signaling pathway for cancer therapy IL13RA2 IL13RA1 TYK2 JAK3 JAK1 PMC5712330__F3 Canonical and non-canonical NFKB signaling pathways IRAK1 RELB TRAF3 TRAF6 IRAK4 MYD88 BIRC2 CARD11 BCL10 BCR RELA BIRC3 SHARPIN CD40 TRAF2 PMC5712330__F4 Regulation of the NFKB signaling pathway by MALT1 and BIRC3-MALT1 CARD11 BCL10 CYLD RELA BIRC3 RELB TRAF6 TNFAIP3 TRAF2 PMC5712330__F5 Targeted therapy in extranodal marginal zone lymphoma MYC TRAF6 IRAK4 MYD88 MTOR IKZF3 BCL6 CARD11 BCL10 IKZF1 BCR BIRC3 TNFAIP3 IRF4 PMC7957700__F1 Normal CD8+ T Cell Response CD37 LCK ZAP70 CD80 PMC6045948__F2 Signal transduction pathways involving c-fos RASGRF1 MAPK3 MAPK1 PMC3905229__F2 Wnt/GSK- 3B pathway MAP1B APC GSK3B PMC9234177__F7 Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment STAT3 BAX PMC6107220__F1 Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies SMOX SRM PAOX SMS PMC8147372__F6 Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the chicken CS GCK PFKM CIT PC G6PC3 FH PDHA1 HEL-S-304 RPIA OGDH PFKP DLAT PGAM1 HEL-S-133P SDHD SDHA HEL-S-281 SDHB MAL HK3 RPEL1 SDHC G6PC2 DLD PFKL HEL-S-162eP HEL-S-68p PDC PMC8875399__F1 F ig . 1.“Find-me” signals and their respective receptors for apoptotic and necrotic cells MFGE8 CXCL1 S1PR2 CX3CR1 CX3CL1 FPR1 S1PR1 S1PR3 S1PR5 S1PR4 THBS1 ABCA1 PANX1 PMC3898811__F7 Schematic diagram as summary of the present investigation MMP2 MMP9 HEL113 CSA2 HEL-S-133P HEL-S-68p PMC4581028__F1 Regulation of cell metabolism by proto-oncogenes and tumour suppressors TSC2 MYC MDM2 PTEN RHEB PMC7874475__F9 Protein-protein interaction network FAM13C ADAMTS3 CDH11 VCAN FBN1 PXDN SDC2 MTHFD2 CDC45 PNPT1 MAF RAD54B NCAPG ZEB2 SMC2 PRRX1 SMC4 SFMBT1 CALD1 TGFBI PMC9513389__F1 Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury GPX4 LPCAT3 STEAP3 FACL4 POR DHODH PMC3607786__F1 MTOR signal pathway in autism spectrum disorders TSC2 TSC1 RYK PTEN EIF4E RHEB PMC8888700__F5 Environment-dependent oncogenic activities of PcG proteins CCR2 PRC1 MICB APP MICA CCL2 EAF2 RXRA GATA2 PMC4048946__F1 Metabolic pathways regulating oxidative stress and endosome traffic controlling the recycling of receptor and adaptor proteins between the cell surface and lysosomes PLCG1 CD2 LCK MIP MTOR LAT CD2AP STIM1 CBL PMC8638142__F10 LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway SOX2 APC YY1 PKMYT1 PMC8888700__F2 Polycomb recruitment and action on target genes CBX2 PRC1 RBBP4 BAHD1 RBBP7 JARID2 EED PMC4490472__F2 Regulation of CUL5, JAG-NOTCH, TNKS2, and PTEN-PI3K-AKT cell signaling by members of miR-17~92 and miR-106a~363 clusters in cervical cancer CUL5 LEP APC LRP5 TNKS PTEN MTOR SKP2 PMC5923449__F2 EV71 induces multiple cellular inflammatory signals and Ca2+-dependent signals EGF COX2 SRC MAP3K7IP1 JUN TAB3 PMC4490472__F3 Regulation of JAG1-NOTCH1-uPA, Cyclin D-CDK4/6-p21-p27, and PI3K-PDK1-AKT1 cell signaling by members of the miR-23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR17~92, miR183~96~182, and miR-302s clusters PLG YY1 CDK4 PTEN FOXO1 CDK6 SKP2 PMC4490472__F1 Regulation of MAPK, PI3K-AKT, and G2-M checkpoint by members of the family miR-125 and members of miR-let-7c~99a, miR-125a~let-7e~99b, miR-100~let-7a-2, and miR-206~133b clusters in cervical cancer PLK1 ATM MDM2 ARHA TRIB2 CDC2 MTOR ATR C13orf34 AURKA CDC42 PMC4784301__F4 Synthetic model of Plasmodium quiescence metabolism CS LIPA FH SDHA PMC12110659__F4 Targeting autophagy to enhance anti-PD-1/PD-L1 therapy CD44 NBR1 PMC9002053__F3 Translational Control of COVID-19 and Its Therapeutic Implication SRP54 ELF2 TBK1 ELF5 STAT2 ELF1 IRF9 IRF3 EIF5 STAT1 ELF3 XRN1 EIF4B MAVS PMC8494307__F7 NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis NLRP3 IL1R1 IL1B PMC6850186__F6 How ablation of IKBNS affects B cell activation and PC differentiation TLR4 BCR RELA PMC12110659__F1 Immune Resistance Mechanisms IL10 IL18 IL13 CCL28 IL6 IL4 IL5 IRF-1 PMC12110659__F2 Autophagy regulation by glycolysis MTOR RHEB STAT3 HEL-S-162eP PMC4030113__F2 Abnormalities in IRS1 interaction in the KEGG PI3K-AKT signaling pathway (PI3K-AKT) CHUK BAD MAP2 GNB5 CSF3 CSF3R MYC PTEN MTOR TNFSF6 MDM2 CASP9 RPS6 RBL2 CD19 CDC37 HRAS IRS1 CREB3 DDIT4 RXRA TSC2 GRB2 PPP2CA BCL2 SYK CRTC2 PMC2890584__F6 Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling HINT1 PDK2 SRC PMC4030113__F3 Abnormalities in IRS1 interaction in the KEGG Oxidative Phosphorylation metabolic pathway ND4L WAS COX2 NDUFA12 NDUFA13 NDUFB10 COX10 NDUFA11 COX7B SDHD SDHA SDHB SDHC NDUFA7 NDUFB2 NDUFAB1 NDUFS3 CYB IRS1 NDUFC2 ND6 NDUFB4 COX3 COX17 ND3 ND2 NDUFB7 NDUFA10 ND4 PMC3703460__F3 Signaling Pathways That Control mRNA Turnover EGF PIN1 GRB2 PMC3703460__F4 Signaling Pathways That Control mRNA Turnover DGCR8 DROSHA PMC5835061__F1 Schematic presentation of synthesis and maturation of BDNF MMP2 PLG MMP9 FURIN BDNF PMC9547753__F3 Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options HMGB1 GPX4 ATG12 GSDMD PMC6209965__F3 Natural compounds as anticancer agents in TNBCs: Mode(s) of Action FOS APC EGFR GSK3B MYC SMO MTOR JUN PMC11005058__F2 Adipocyte leptin promotes lymphocyte activation and TH17 differentiation BCR LEPR IFNG STAT3 PMC6737310__F4 Inflammatory mediator network between cytokines and signaling pathway in liver fibrosis IL10 IL22 IL6 STAT3 PMC6698603__F6 Possible mechanism of drug resistance related to miR-326 in pediatric acute lymphoblastic leukemia (pALL) leukemic cells ABCA3 SMO ABCA2 PMC6976905__F7 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC CCND1 FZD4 EZH2 PMC6976905__F1 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC CCND1 FZD4 EZH2 PMC10529739__F3 Signalling pathways and transcription factors involved in MSC senescence SIRT2 NAMPT SIRT7 NMNAT1 SIRT4 SIRT5 SIRT6 MSC NMNAT3 MTOR SIRT1 SIRT3 PMC5105076__F8 Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism COX2 COX1 STAT3 PMC3365861__F6 Opposing roles of Myd88 and RAGE in extensive liver resection PIM1 GLO1 MYD88 STAT3 PMC9325148__F2 Succinate as a New Actor in Pluripotency and Early Development? COX2 MFF COX1 SUCNR1 PMC4557106__F3 Pharmacologic modulators of the Hippo pathway APC TBX5 LATS1 YES1 RHO LATS2 PMC1705980__F2 Schematic model of autophagic regulation PTEN MTOR PMC2134905__F2 The p53 pathway and IGFBP3 IGF1 BAX PMC6430710__F5 Complementary pathways in DNA double strand (ds) break repair and PARP inhibitor response POLE BRCA2 RAD51 PARP1 BRCA1 PMC10743706__F2 Biosynthetic pathways of BR CS BROX CPD PMC12251215__F3 In esophageal and gastric cancers (EC and GC, respectively), circRNAs modulate Wnt/Beta-catenin signaling through various mechanisms FZD3 GC SRXN1 SOX4 ITCH PMC2517296__F1 The co-ordinated activation of pro-inflammatory signalling pathways by TLR ligands and the pro-inflammatory cytokines TNFA, IL-1 and IFN TRADD TRAF5 TRAF6 PTEN MYD88 TRAF2 PMC7962935__F1 Downstream signaling of Frizzled proteins (Fzds) APC GSK3B LRP5 LRP6 RHO PMC12251215__F2 Wnt Signaling Pathways: canonical (Wnt/Beta-catenin) and non-canonical (Wnt/planar cell polarity, PCP and Wnt/Ca2+) pathways DAAM1 APC LRP5 LRP6 ARHA ROR2 RAC1 ROR1 PMC3753234__F7 Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway FGF2 SRC ARHA PMC8314420__F2 Genetic syndromes with vascular malformations – update on molecular background and diagnostics ALK SMAD4 ENG SMAD1 DKFZp781O1323 PMC2688657__F5 Growth signal pathway EGF FYN MAX EGFR MYC GRB2 RASSF2 TGFA JUN PMC2688657__F3 Apoptosis pathway CASP3 CASP6 BAD TRADD ATM CASP9 BCL2 PTEN KRT18 CASP8 FADD BAX PMC2688657__F1 Antigrowth signaling pathway and cluster around SMAD proteins SMAD2 TGFBR1 TGFBR2 MYC SMAD4 CDK6 SMAD9 RHOD PAPOLA HNF4A CDK2 MDM2 CDK4 SF3B2 GPNMB PSMD11 PMC8282792__F8 Proposed model for the dysregulation DEPDC5-mTORC1 axis in the pathogenesis of alcohol-induced hepatic steatosis DEPDC5 KLHL22 NR1C1 PMC3757153__F2 Treatment advances in neonatal neuroprotection and neurointensive care APAF1 PARP1 CAD FADD PMC9153171__F2 Metabolomic, proteomic and lactylated proteomic analyses indicate lactate plays important roles in maintaining energy and C:N homeostasis in Phaeodactylum tricornutum CS CIT MAL PMC7672569__F2 Targeted signalling pathway involved in endothelial cells (ECs) activation and vascular smooth muscle cells (VSMCs) proliferation and migration during intimal hyperplasia PGR HEL-S-11 VEGFA SRC ARHA PMC7926043__F8 Mapped proteins and genes in the glucocorticoid receptor signaling pathway, the role of JAK2 in the hormone-like cytokine signaling pathway, and the TNFR1 signaling pathway CASP3 PTPN11 FKBP5 JAK1 TNF TRAF2 PMC6032287__F1 Phoenixin-20 stimulates the mRNA expression of GnRH, GnRH receptor, Kiss1 peptide, and GRP173 via the cAMP-PKA pathway and CREB phosphorylation mediated by the GPR173 GNRHR EBP GPR173 KISS1 PMC10944245__F9 Cytotoxic effect of flavonoids related to MAPK and PI3KAkt pathways EGF BRAF PTEN PMC8819497__F9 DDR‐dependent matrix‐mediated drug resistance (MMDR) to MAPK‐targeting therapies in melanoma DDR1 RELB DDR2 PMC3899934__F2 Farnesoid X receptor–Acting through bile acids to treat metabolic disorders PCSK9 CYP8B1 ABCG8 ABCG5 LPL LDLR TG CYP7A1 PMC9673319__F3 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease BACE1 ADAM10 PACS1 SNX27 PMC9673319__F8 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease NGF PSEN2 PSEN1 ABO APP PICK1 SORCS3 PSD PMC22667__F1 Pheromone response pathway in yeast and summary of epistatic interactions with STE4 and STE11 FAR1 CLN3 CDC42 PMC9020878__F12 Huangqin Tang Interference With Colitis Associated Colorectal Cancer Through Regulation of Epithelial Mesenchymal Transition and Cell Cycle CCND1 CDK4 PMC9673319__F6 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease VPS35 ABO SORCS1 BDNF PSD ADAM17 PMC8533944__F2 Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance PTF1A FOS AREG EGFR MYC GRB2 LATS1 PMC10740436__F3 Comparative Serum Proteome Profiling of Canine Benign Prostatic Hyperplasia before and after Castration UBC EGFR GSK3B GRB2 TNK2 PIGR FRAT1 DVL1 CDC42 PMC11913433__F8 M6A modification-mediated MTHFD2 upregulation drives tumor-promoting effects via the PEBP1-RAF1/MEK/ERK signaling cascade METTL3 HEL-S-34 IGF2BP2 MTHFD2 PMC8492102__F4 Unboxing the molecular modalities of mutagens in cancer TBK1 CGAS ATR IRF-1 PMC3259192__F2 Sphingolipid Signaling and Hematopoietic Malignancies: To the Rheostat and Beyond BAD SPHK1 GAL STAT3 BAX PMC4389563__F1 Time-resolved metabolic reprograming during pro-inflammatory macrophage polarization COX2 TLR4 F2 IL6 PMC6087673__F1 Apoptosis in Acetaminophen Hepatotoxicity CAD FADD BAX PMC8555029__F4 Cellular mechanosignaling in pulmonary arterial hypertension TRPV4 TRPV3 NOTCH3 PMC4625494__F1 Tubulin folding cofactor D (TBCD) cooperates with Dscam during neuronal morphogenesis.(A, B) Schemes of wild-type (A) and TBCD mutant (B) projection neurons TBCD TBCB WAS DSCAM PMC6747374__F8 Signaling pathways involved in the AVP-dependent myogenic differentiation AVP MTOR PMC7648688__F8 Network of potential core targets and signaling pathways in the treatment of IS by AT MPO F2R PTGS1 MMP3 PLAT MMP2 F2 F3 NOS2 JUN IL1B PTGS2 MMP9 NFE2L2 VEGFA PTGES RAC1 TNF NR1C1 PLA2G1B PIK3CA ACD PRKCH PLA2G2A PPARG FABP1 PMC8126512__F2 Intersection of COVID-19 and cancer: signaling pathways and treatment implications INA BTK IL6R STAT3 PMC3020075__F1 GPC5 Gene and Its Related Pathways in Lung Cancer GPC5 SUFU APC LRP5 GRB2 LRP6 PMC9562648__F2 Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities TBK1 NLRP3 CGAS TLR9 IRF3 AIM2 IL1B BAX PMC8892093__F6 Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology BACE1 CDK5 APP PMC12178073__F4 Regulatory role of DEAD/H box helicases in the toll like receptor (TLR) signaling pathway TBK1 TLR9 IRF7 IRAK1 DDX1 TRAF3 TRAF6 DHX36 IRAK4 IRF3 S100A9 MYD88 TLR1 DDX24 TLR3 TLR8 TLR7 TLR4 NFKB1 RELA PMC9207346__F4 Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence ATM RAD50 CDK4 ATR MRE11A PMC2834552__F11 Schematic diagram of AGE-induced CTGF expression is shown SMAD2 SMAD4 PMC7590703__F1 Functional and cell number defects in NK cells caused by different PIDs RTEL1 RAB27A IRF8 IL2RG LYST FHL2 ADA PRF1 WAS GATA2 PMC12074830__F5 TLR signaling pathway TLR4 IRF7 TRAF3 TRAF6 MYD88 CP PMC4317900__F3 Disease-specific mutations in T-cell large granular lymphocytic leukemia and natural killer (NK)/T-cell lymphoma IL15 JAK3 JAK1 STAT3 PMC4317900__F1 Disease-specific mutations in B-cell lymphoid neoplasms ECD BRAF IRAK1 MYC TRAF6 IRAK4 PTEN MYD88 MTOR MAP3K7IP1 CCND3 CD79A ID3 BTK CARD11 BCL10 BASH MDM2 SYK TIRAP PMC2633398__F9 An epistatic pathway and genetic model for replication slowing in fission yeast SWI5 CDS1 DMC1 RAD51 SFR1 PMC10140952__F4 Selected molecular targets of resveratrol EGR1 HGF PLK1 ATG12 EGFR PTEN AURKA DKFZp686F0183 STAT1 TLR4 IGF1 CYP3A4 CDK2 HEL-S-44 SYK ABCG2 ATG14 ABCB1 SIRT1 STAT3 BAX PMC9031669__F2 Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids CYP27A1 GCA AKR1D1 CYP7B1 BAAT CYP7A1 PMC7763461__F1 Toll-like receptor (TLR) signaling pathways TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 IL1B PMC8457632__F2 Antiviral Immune Evasion of SARS-CoV-2 STAT1 SRP54 RAE1 NUP98 IRF3 SRP19 PMC6404589__F5 Differential regulation of neurotrophin signaling pathway genes BAD NGF DAO FRS2 GRB2 BDNF CRK BAX PMC6100584__F1 Mechanism of Hedgehog pathway activation SUFU PTCH1 GSK3B MYC SHH SMO PMC4705542__F5 Schematic summary of the proposed photoneuroendocrine control of VGF expression CRABP2 VGF ARC PMC6100584__F2 Crosstalk of the Hedgehog pathway with other protumorigenic pathways EGF SOX2 IGF2 BCL2 SMO MTOR HES1 PMC6651373__F3 The molecular mechanism of DAPK1 in AD PIN1 NDRG2 APP PMC10474047__F8 Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell motility during gonadotrope differentiation ZYX ND1 CSK PTPN1 PTPN11 NTRK3 PTPN13 NEUROD1 SRCIN1 DAB1 ND4 PMC8040299__F10 Pattern diagram HHT influence miR-18a-3p and AKT/mTOR signaling pathway MMP9 BCL2 MTOR BAX PMC9746897__F2 Pyroptosis: A new insight of non-small-cell lung cancer treatment CASP3 NLRP3 HMGB1 GSDMA GZMA TNF GSDMC CASP8 GSDMB GSDMD IFNG DFNA5 PMC10377067__F7 Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MG ACADS ACADM GLS PMC5214967__F1 Biosynthesis of the lipid-linked oligosaccharide precursor for N-linked glycosylation and known defects in this pathway DPAGT1 ALG13 DOLK DPM2 DPM3 RFT1 DPM1 ALG1 STT3A ALG3 ALG12 STT3B ALG6 ALG10 PMC3830611__F1 Circuitry and biochemical basis for Tuberous Sclerosis symptoms: From Epilepsy to Neurocognitive deficits TSC2 TSC1 RHEB PMC3420937__F6 PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development EGFR GRB2 PTEN INSR PMC8617589__F10 Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity CEBPD LCN2 TXNIP SELENOM TXN STAT3 PMC9200662__F7 Model for the role of the sequential modification of ERA by UFM1 and ubiquitin in the transactivation pathway UFM1 CCND1 PMC8016657__F2 Roles of Epac in synaptic plasticity, neurodevelopment, and cell death RAP2B BRAF MTOR PMC2999296__F2 Toll-like recepter 4 signaling pathway modified from Wikipedia Commons TBK1 CD14 TLR4 IRAK1 LBP TRAF6 IRAK4 MYD88 TIRAP PMC4335664__F3 The crosstalk between the IGF-1 system and estrogens in breast cancer IGF1R IGF1 MTOR IRS1 PMC7582192__F5 Targeting N-myristoylation for therapy of B-cell lymphomas BCR SYK CD79B ARF1 CD79A PMC5852553__F9 Rac signaling pathway PC CD44 CDK5R1 ARHA JUN CDC42 PMC8413680__AF1 LINC00941 promotes glycolysis in pancreatic cancer by modulating the Hippo pathway YAP1 ENO1 HEL-S-133P HK2 PMC4859755__F1 Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer PRSS1 PLG SPINK1 PTEN CFTR PMC6770103__F4 Differentially expressed genes in the neurotrophin signaling pathway between mandarin fish at CG and LG from a transcriptome analysis FRS2 GRB2 SHE APP TRAF6 RAC1 BDNF CRK PMC6585541__F1 Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar? NLRP3 CXCR4 CASP14 PMC6770103__F5 Differentially expressed genes in the cyclic AMP (cAMP) signaling pathway between mandarin fish in the control group (CG) and the learning group (LG) from a transcriptome analysis GHRL AMH RHO PPARG PMC6021501__F2 Role of apolipoproteins during early steps of hepatitis C virus (HCV) entry APOB CLDN1 EGFR LDLR HRAS APOE CD81 PMC2747008__F12 Induction of IFNB and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7 TBK1 STAT1 STAT2 ATF2 TRAF3 TRAF6 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 JUN PMC7757029__F3 Alternations of signal pathway of MYC in breast cancer tumorigenesis LEF1 FOS APC MYC LRP5 CCND1 LRP6 CDK4 RB1 SP1 JUN CDK6 PMC8523029__F1 12(S)-HETE/GPR31 Signaling Pathways RHO GPR31 TF PMC6607099__F1 Potential mechanism of Fn in CRC TIGIT MYD88 GAL PMC1571066__F2 TGFB superfamily signalling pathway (see text for explanation) SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC6874443__F5 Functional enrichment analysis and construction of PPI network CCR5 CD3D ARHH UBASH3A TIGIT IKZF3 SIRPG IL12RB1 MAP4K1 CORO1A PSTPIP1 BATF TBC1D10C CXCR3 CD27 IL2RG CD2 LCK SIT1 TRAF3IP3 GFI1 SLA2 SASH3 CD3E PMC1571066__F5 Model of SMAD7 role in control of blood vessel calibre (see text for explanation) SMAD1 DKFZp781O1323 PMC6019445__F1 Schematic describing invariant natural killer T (iNKT) cell development and function in the thymus CD1D EGR2 CCL17 TEC AIRE CCL22 GATA3 CD69 CD24 PMC8344376__F2 SASP regulation DNASE2 ATM TREX1 IRF3 STC1 MTOR GATA4 BRD4 PMC3960235__F3 The Anti-Hypercholesterolemic Effect of Low p53 Expression Protects Vascular Endothelial Function in Mice CYP7A1 PMC6368838__F4 Identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes WDR83 NAMPT C14orf119 EGR1 MRPL35 ZNF420 NKX3-2 DEAF1 MZF1 RAB10 PMC9190019__F6 Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation EGFR TGFA RHBDF1 RBM4 PMC9034917__F9 Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment BCL2 IL1B BAX PMC3293036__F1 The Wnt signaling pathway in cancer cells TSC2 TSC1 APC GSK3B LRP5 LRP6 MTOR RHEB PMC9630943__F3 IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis TLR4 IRAK1 SIGIRR IL33 TRAF6 IRAK4 MYD88 PMC6928633__F3 Constructed metabolic pathway that integrated relative metabolite contents and gene expression for three different sizes (small, medium and large) of beech mushrooms PMC3139189__F1 Intrinsic pathway of apoptosis BAD BIK CAD BMF DIABLO BAX BOK PMC9274081__F2 Inflammation in Cardiac Remodeling After Acute Myocardial Infarction NLRP3 CRP IL1B PMC3139189__F2 B1/Fak/Src integrin signaling, cell survival, and suppression of anoikis BAD FYN HEL-S-28 GRB2 SRC BMF PMC3139189__F3 Common pathway of anoikis induction CASP3 BAD CASP9 SRC BMF DIABLO PMC7508434__F5 Diagram for the molecular mechanism CXCL14 STAT3 PMC3062538__F5 The regulation of IgA class switching CD40 PIGR TSLP TGFB1 TGFBI PMC6575164__F3 Possible mechanisms of action of targeted polyIC TBK1 EIF2A TRAF3 IRF3 TLR3 MAVS PMC5852553__F4 Phosphatase and tensin homolog (PTEN) signaling pathway BAD GRB2 PTEN CBL PMC11968285__F7 SONFH reveals that BMSC Piezo1 in response to elevated IOP regulates bone vascular homeostasis through CAM-NFAT1 signaling pathway RUNX2 PIEZO1 CXCL12 PMC8198713__F12 Novel Characterization of Constipation Phenotypes in ICR Mice Orally Administrated with Polystyrene Microplastics AQP3 AQP8 MUC2 CFTR PMC5973372__F1 Hippo信号通路。A：果蝇中的Hippo信号通路；B：哺乳动物中的Hippo信号通路。Hippo signaling pathway ABL2 SOX2 AMOT CD44 LATS1 RHO CUL4A LATS2 HMGCR FAT4 NF2 SKI FRMD6 ITCH PMC4940412__F4 Glycolysis superpathway gene expression profiles SDHC ENO1 SDHD SDHA SDHB PMC9147752__F2 Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration FOS NACA MTOR JUN PMC7698326__F1 GWAS of fibrosing disorders CDH23 IRAK1 IL12A IKZF3 UMOD NOD2 DKFZp686F0183 DPP9 MYO1E CTGF CAV3 IL17RA IL7R SERPINB2 IRF4 GCKR TNLG1B IL1RN CXCR5 STC1 CTLA4 IL6 TNF MUC5B RAD18 IL12RB1 NEDD4 MYO7A LTA COL4A3 SPIB ARHGAP31 NFKB1 BANK1 STAT4 TNFRSF1A PRKAG2 CD80 MC1R TGFB1 TERT PMC9318662__F1 In Silico Approach in the Evaluation of Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds through Binding Affinity to the Human Toll-Like Receptor 4 CD14 TLR4 MYD88 TIRAP PMC10778111__F3 Non-coding (nc)RNA-regulated signaling pathways involved in gastric cancer invasion SMAD2 APC EGFR SMAD4 RHO DKK1 MTOR CDC42 PMC9138354__F1 Synergistic Cooperation between TGFB and Hypoxia in Cancer and Fibrosis MMP2 APPL2 PSEN1 MMP9 SMAD4 TRAF6 IL6 RHO APPL1 PMC9354699__F7 Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration SMAD2 PCNA PMC6579679__F8 Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart SMAD2 SMAD4 ARHA PMC7734100__F2 How coronavirus disrupts signaling pathways (autophagy, ER stress, cytokine storm, and hypoxia) and induces cell death ULK1 PLP2 ATF4 EIF2A XBP1 SKP2 PMC8102340__F1 Project flow chart summarizing analyses and key results KY GPC3 EPHA7 NAT1 SPTBN5 NOTCH3 TTC28 COL22A1 OR11H4 FSIP1 AKR1D1 EVI2B ERCC5 SMPDL3A MAF1 CENPQ OSTM1 SDK2 PRKDC ST6GALNAC2 PMC4120684__F2 Comparison between recombinant Shh- and EVsShh+-activated pathways modulating angiogenesis and apoptosis in endothelial cells HGF SHH SMO ARHA PMC7899295__F3 WNT pathway mutations underlie vitreoretinopathies that have phenotypic overlap with pathologies seen in the DC spectrum diseases TSPAN12 LRP5 PMC2655360__F7 Pathway maps generated using GenMapp depicting increased glycolytic protein expression in differentiated intestinal epithelial cells relative to crypt cells ALDOB GCK DLD PFKM HEL-S-87p PAH HEL-S-162eP GOT2 PC HEL-S-278 PRLR FAP PDHA1 DLAT PGAM2 HEL-S-281 PMC4202134__F7 Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk BAD MDM2 PTEN FADD BAX PMC8815749__F5 Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD ULK1 TSC1 VHL MTOR PMC6981291__F1 Crosstalk between Nrf2 signaling and Mitochondrial function in Parkinson’s Disease ME1 GCLM ABCB7 FES HEL-S-44 ENO1 HEL107 HMOX1 PRX TF HK2 HEL-S-162eP PMC5080294__F2 Proposed model for the targeting of NRAS-mutant melanoma by ERB ligands BLM NRAS CCND1 CCND3 PMC3196718__F4 Network of upregulated genes in C2C12 cells treated with rhBMP2 and rhBMP7 using the STRING 9.0 pathway analyzer BAD FOXO4 POSTN PLOD1 LRP6 CREB1 DKK1 GLIS3 CFDP1 ID1 GRN NKD2 ID3 HTRA1 GLIS1 DAAM1 WNT3A GIG8 AXIN1 ECSIT KAZALD1 SMAD1 SIRT1 PMC9350078__F3 NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients IL18 CD34 TNF PMC6668540__F2 TLR signaling pathways IL16 IRF7 TRAF6 IRF3 IRAK4 PMC2727911__F1 Activation pathways of the complement system and complement regulatory proteins HEL-S-62p CD59 C4B_2 MASP1 C7 C6 MASP2 C1S PMC3741439__F1 The catecholamine biosynthetic pathway TH PNMT DDC PAH PMC2268064__F2 Signalling pathways leading to the phosphorylation and inhibition of glycogen synthase kinase 3 (GSK3) EGF GRB2 MTOR PMC4017002__F8 PPARB/D promotes HRAS-induced senescence by potentiating p-ERK and repressing p-AKT HEL-S-28 MDM2 PDPK1 PMC9621439__F2 Mammalian and basal innate immune signaling via NFKB CGAS IRF7 IRF3 PMC2268064__F3 Regulation of the transcriptional co-regulator Beta-catenin LEF1 APC PMC5825873__F2 Pathways that regulate mTORC1 and mTORC2 signaling EGFR GRB2 PTEN RHEB PMC3075080__F3 Proposed ACE2/ANG-(1–7)/Mas signaling pathways in the central nervous system ACE2 STAT3 MLN PMC6164903__F3 Innate immune response to baculovirus infection in non-immune cells TBK1 CGAS IRF3 PMC6164903__F2 Induction of innate immune response by viral infection TBK1 TLR7 TLR9 IRF7 IRF3 MYD88 TLR3 PMC11172187__F1 Gliogenic switch during brain development GFAP NFIA SOX9 HES1 PMC4961994__F2 Summary of TGFB signaling during EMT HMGA2 TWIST2 TWIST1 ZEB2 TGFBR1 FOSB JUNB PMC11703747__F2 Cellular metabolic pathway involving GOT1 HIF1A SIRT1 FOXP3 PMC6337314__F2 TREM2 activation and downstream signaling SYK ADAM10 LAT ADAM17 TYROBP PMC10534826__F2 Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer TH CS PC COMP GLS PMC6135256__F4 The effects of NBUVB on the bulge and epidermis of human vitiligo skin during repigmentation TNC SNAI1 IGF2BP1 FZD7 SFRP1 THBS1 GJB6 SOX9 PMC4603759__F6 Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism RRM2B GPAT2 RRM1 GCLC RRM2 HEL-S-64p GPAM PMC6631457__F8 Schematic showing that exosomes carrying miRNAs promote NDV infection STAT1 IRF7 IRF3 MAVS PMC10377020__F1 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review KEAP1 ATF4 XBP1 PMC10377020__F2 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review MAF NFATC2 CTSK KEAP1 NFATC1 MMP9 OSCAR DCSTAMP SRC TRAF6 ATP6V0D2 SIRPB1 PMC3320973__F8 Wnt signaling regulation induced by cell surface HSPG desulfation during dentinogenesis SULF1 SULF2 DSPP WNT10A PMC7369957__F1 Canonical Wnt pathway APC LRP5 LRP6 PMC5902714__F8 Summarized scheme for the regulation of spexin on bile acid pathway CYP27A1 GCA CYP8B1 HNF4A GALR3 GALR2 BAAT PMC12122839__F2 Generation and metabolism of sulfur-containing biomolecules HEL-S-61p DAO MTOR RHD PMC4102744__F1 Cytoplasmic/traditional and nuclear modes of the epidermal growth factor receptor (EGFR) signalling pathway EGF EGFR CCND1 STAT3 PMC12122839__F3 Sulfide signaling pathway TSC2 TSC1 KEAP1 SMAD2 APC SMAD4 ARHA RHEB PMC4632082__F6 CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity NFATC1 CD44 SRC TRAF6 PMC6647228__F2 Schematic presentation depicting the energy metabolic pathways through which AMPK controls the activation of MDSCs NFE2L2 MTOR STAT3 CD36 PMC6924059__F4 ARHGAP9-mediated regulation of the MAPK signaling pathway in BC EGF EGFR PMC7801920__F2 Related molecules, genes, signaling pathways and biological function in HCC of miR-200 family RBBP4 ZEB2 BMI1 RHO PTEN PBX3 FOXA2 PMC4445742__F4 Model depicting PPP1R12A/PP1cD in the insulin signaling pathway GRB2 IRS1 PMC4276281__F2 Schematic of the major pathways of serine metabolism in a mammalian liver PSAT1 PSPH PHGDH PMC5122694__F3 Canonical pathways by IPA: antigen presentation pathway in the NC vs MHC2TA HEL-S-99n IFNG PMC4927194__F2 Diverse extracellular signaling pathways are regulated by A disintegrin and metalloproteinase (ADAM)-mediated shedding events EREG EGF AREG CD44 HBEGF NRG1 IVL ADAM17 BTC VCAM1 DLL4 ADAM10 TGFA PMC3240717__F9 Pro-inflammatory Cytokine/Chemokine Production and Breast Tumor Invasion CD44 MYD88 IL1B PMC6942368__F7 Role of liraglutide in regulating hCMSC paracrine and SPC expression FGF10 TCF4 PMC6558915__F10 Schematic presentation of the anti-TNBC mechanism of Ilamycin C MMP2 MMP9 PARP1 STAT3 BAX PMC5122694__F1 IPA Canonical Pathway analysis showing the interferon signaling pathway across the NC vs STAT2 IRF9 TYK2 JAK1 PSMB8 SOCS1 IFNG MX1 BAX PMC5122694__F2 Canonical pathways by IPA: antigen presentation pathway in the NC vs ALB HEL-S-99n IFNG PMC2893543__F4 Schematic overview of costimulatory receptors and their ligands CD27 TNLG8A CD40 ICOS PMC8961590__F1 Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases DGCR8 GSK3B DROSHA PTEN RBFOX2 LIN28A MTOR IRS1 RBFOX1 INSR PMC10522861__F7 Analysis of the response mechanisms of Pinellia ternata to terahertz wave stresses using transcriptome and metabolic data TPM1 BIN2 EBF2 PMC5007826__F6 Working model of PRL-3 involvement in TNF-R1 pleiotropy TRADD TRAF2 FADD PMC6380503__F1 Metabolites as regulators of insulin sensitivity and metabolism TLR4 PC IRF3 MYD88 MAP3K7IP1 IRS1 PMC5374731__F2 Schematic summary of genetic abnormalities in ATL cells PLCG1 KY ARHA PLCG2 CARD11 BCL10 TP73 NOTCH1 HNRNPA2B1 IKZF2 IRF4 GPR183 GATA3 STAT3 PMC8416371__F8 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis INA ChAT BAD HEL-S-11 C1S RAN tal-1 PMC8416371__F9 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis MAX TRADD APP TEC TNF PMC8334720__F1 Interplay Between mTOR and Hippo Signaling in the Ovary: Clinical Choice Guidance Between Different Gonadotropin Preparations for Better IVF CYR61 RPS6 CCND2 PMC4316815__F2 Regulation by zinc of the ERK1/2 signaling cascade CSK BDNF GPR39 PMC6927014__F6 Protein–protein interaction and pathways analysis EPOR TRADD PCK1 CSF3R MYC TRAF3 BCL2L1 PTEN COX2 BCR ATM FRK BASH MDM2 IL7R VWF THBS1 PCK2 YWHAG IL1B LAMC2 BFAR RBL2 ITGB3 TES LTB TNF TRIM25 CARD11 LTA ITGB7 VCAM1 ITGA6 LCK LBP LYN CD40 TNR SYK LAT PMC5443811__F8 Illustration of the chondroprotective effects of sUA and the mechanisms underlying these effects ADAMTS4 IL1B PMC7802442__F4 Case of UDP-Galactose 4′-Epimerase Deficiency Associated with Dyshematopoiesis and Atrioventricular Valve Malformations: An Exceptional Clinical Phenotype Explained by Altered N-Glycosylation with Relative Preservation of the Leloir Pathway GAL PMC6570467__F6 Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining NAMPT HEL-S-97n P4HA1 UGDH IDI1 GFPT1 HEL-S-68p MTAP PNMT FADS2 ACSL1 HEL20 GSTM3 HEL-S-133P PMC3343040__F6 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease TM7SF2 CYP51A1 STARD4 ACOX1 HES1 HEL-S-26 CYP27A1 A2M GOT2 MMP2 TCF20 GHR SREBF2 LPL ACSL1 F11R NAMPT PSAP HMGCR FER TIMP1 INSIG1 DUSP16 HBB LITAF CXCL12 HLA-DMB SLC39A6 SLC36A1 FXYD5 CCDC62 F2R NR3A2 FCGR2A EBP ANXA6 RAB30 HLA-DMA FKBP1A HTATIP2 C1QA ACTN4 STAR PNPLA2 HMGB1 ME1 SDC1 CYP1B1 PCOLCE HEL-S-130P LIPE STAT4 SLC27A1 SMPD1 SLC1A3 PSMB10 PMC3343040__F7 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease NAMPT PLB1 F2R ANXA11 NR3A2 DKFZp781B1423 HEL-S-53e GPR176 HEL-S-130P HMGCR DNAJC15 EDN1 MAPK13 LIPE TIMP1 LGALS3BP MMP2 PKIA SPHK1 CXCL12 ACTN4 HLA-DMB PMC3763401__F1 Crosstalk between COX-2 and EGF signaling pathway in CRC EGF COX1 EGFR CCR7 GRB2 PMC9698582__F11 G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells GPR37L1 MTOR PRKDC PMC4331529__F8 miR-30 Family microRNAs Regulate Myogenic Differentiation and Provide Negative Feedback on the microRNA Pathway TNRC6A SMARCD2 SNAI2 PMC5715847__F1 B‐Catenin‐dependent pathway APC GSK3B PMC5715847__F2 Wnt/PCP pathway DAAM1 ROCK1 ARHA RAC1 JUN PMC6824464__F1 Glycolysis and pentose phosphate pathway PFKM HEL-S-133P HEL-S-162eP PMC8039141__F2 The different mechanisms involved in Senescence Associated Secretory Phenotype (SASP) regulation CGAS ATM TRAF6 IL1R1 TRAF3IP2 MTOR CEBPB GATA4 BRD4 PMC9203716__F3 Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types EBP STK11 BCL2 PTEN SGK1 POLI PMC9115384__F3 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application SKIL CXCL10 CCL5 PMC9115384__F1 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application ATG16L1 ATG12 ATG3 ULK2 UVRAG STX17 MTOR ATG14 DKFZp686F0183 NBR1 PMC5715847__F3 Wnt‐cGMP/Ca2+pathway NLK CDC42 PMC8080617__F3 Active D-secretase is the trigger for both AD and PD SRPK2 ALDH2 PMC7914561__F1 Methionine cycle HEL-S-61p PMC9312434__F3 Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury LYN GSK3B SRC STAT3 PMC3615463__F1 Phosphoinositide 3-Kinase Inhibition in Chronic Lymphocytic Leukemia BTK BCR LYN SYK PTEN MTOR PMC3799998__F1 Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila ULK1 ATG12 ATG3 AMBRA1 ATG101 ULK2 UVRAG ATG10 MTOR ATG14 DKFZp686F0183 PIK3R4 PMC9622871__F8 Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions PIG59 RPE PMC7894463__F2 Lumped network of the carbon metabolism of Rhodobacter sphaeroides, including pathways for substrate uptake and product formation HEL-S-62p CS C6 IPP MAL PMC5306179__F1 Canonical and alternative pathways for NFKB activation BCR RELB DAP REL TNF PMC6650903__F4 Schematic plot of significantly differentially expressed genes involved in GA metabolism and signaling under CK, CCC, and PBZ treatments in roots and shoots CP PIF1 PMC7760945__F3 Intra-articular (IA) delivery of cargo-loaded nanoparticles for the treatment of OA IL18 IL1B PMC9465182__F1 Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice CARD9 BCL10 PLIN1 PMC2490739__F8 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway SPR SSB PCNA PMC9184651__F4 Signaling pathways of chronic kidney diseases, implications for therapeutics SMAD2 CXCR4 NOX4 PMC3009741__F3 Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections TLR4 NOD1 CCL2 MYD88 TNF NOD2 PMC6905557__F6 Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound RFC1 MLH3 PKP1 MCM2 GPN2 CIB3 CDC42 PMC4530997__F1 Selective delivery of ITCs to bladder on oral consumption and modulation of cellular targets by ITCs in BC cells and tissues EGFR PMC7405402__F2 Cell cycle of SARS‐CoV‐2 in the host cells NPS GAL ACE2 TMPRSS2 HEL-S-69p PMC5869526__F1 Interferon-like antiviral response ADAR CGAS TYK2 MYD88 RHD MAVS PMC6476530__F1 Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy TSC2 TSC1 PLK1 CDKN2B CDKN2D CAB39 MTOR PMC10313451__F6 Imipramine mechanism of action in breast cancers ERG CDK4 ATR BRCA1 PMC3315209__F6 Speculative model for the role of the Hippo pathway in germ cell tumorigenesis and reprogramming DND1 LATS2 PMC3494597__F1 Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells UBE2M MTOR DEPTOR DKFZp686F0183 NAE1 PMC5877528__F6 The AR induction pathway in ‘T337’ basal cuttings XK ARR3 CLU HEL-S-162eP PMC8418153__F2 Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease HEL-S-102 GPX4 IREB2 SLC3A2 TF PMC9458733__F4 Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer’s disease (from the Nakayama Study) AZIN2 ARG2 SMOX OAZ1 SRM OAZ2 OTC ARG1 NAGS SMS ASL OAZ3 PMC9523169__F3 Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD HERC2 FTH1 PMC3978582__F4 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs HEL-S-97n CHST12 SLC39A8 SPRY2 CBL HEL-S-49 SIRPA MMP14 PCP4 CRIP1 HEL-S-112 PFKP LMO7 HK2 PMC3978582__F5 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and experimental discs TANK c-fgr MAP2 NOD1 BCR HP AEBP1 NFKB1 RELA CYBB IL23R PMC3065471__F3 Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map MAF OGT FTL UBB PMC8669610__F4 TGFB Signaling and Resistance to Cancer Therapy CCL5 CCL2 FOXP3 PMC6304490__F2 Examples of in vitro molecular action of quercetin (Q) in cited cellular experiments FOS WAS TGFA JUN PMC7164363__F7 EphB4, TNFR2 and ERK/MAPK signaling pathways TRAF3 TRAF2 PMC8665957__F1 Review: the effect of light on the key pigment compounds of photosensitive etiolated tea plant UROD UROS CPOX POR PMC3978582__F3 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs ITGA1 MXD1 EGR1 MARCKS E2F6 CD44 CREB1 EZR hCG_2044782 GADD45A HMOX1 GLRX SIK1 MNS1 PMC8669610__F1 TGFB Signaling and Resistance to Cancer Therapy GRB2 TRAF6 RHO MTOR TRAF4 PMC8669610__F3 TGFB Signaling and Resistance to Cancer Therapy HMGB1 USP27X SMAD2 SMURF2 HERC3 SMAD4 ABCG2 PMC4529925__F3 Model of SAM68 interaction with pre-mRNAs and splicing regulation CD44 SRC BCL2L1 MTOR PMC4940389__F1 Regulation of HH and Wnt/Beta-catenin signaling by 1,25(OH)2D/VDR and calcium/Casr CYP27A1 VIT NR1i1 CYP2R1 PTCH1 SHH SMO PMC7006399__F6 Gene network analysis and interaction subnetworks PRKCI BRAF PCK1 GSK3B HEL-S-99n PDE6A RHO CYBB MTOR HEL-S-68p CANX HEL-S-80p ALDH7A1 GNAT2 GNAT1 G6PC3 ITGAV DLAT PMC6400144__F2 Regulation of the C-type lectin receptor signalling pathway by curdlan and MacroGard® TH CAP1 STAT2 CYLD IL3 IL27 MDM2 RELB SYK IL6 CCL2 PMC4632638__F2 Ibrutinib: a first in class covalent inhibitor of Bruton’s tyrosine kinase BTK CARD11 BCL10 LYN SYK MYD88 CD79B CD79A PMC5987014__F2 Sclerostin and the Wnt/Beta-catenin signalling pathway APC SOST LRP5 LRP6 PMC4903900__F1 Epigenetic modulation of gene expression governs the brain’s response to injury PRC1 YY2 SIRT1 PMC7014054__F15 PtNPs change transcriptional networks MAF EGR1 EGR2 STAT2 RUNX2 TSC22D3 FOS ATF4 ATF3 JUND TNF JUN PMC321618__F7 Statins and bacterial infection: model illustrating the effects of statins on S. enterica serovar Typhimurium infection TH PLG RHO PMC1664665__F2 Regulation of the axon cytoskeleton by PI3K signalling APC GSK3B RHO CDC42 PMC1664665__F3 ECM-integrin signalling coordinates with growth factor signalling to regulate efficient axon growth HEL-S-28 ARHA CDC42 PMC3018769__F8 Composite figure from all time points of microarray data showing apoptotic pathways in HepG2 cells when exposed to PCB-153 (70μM) and PCB-77 (70μM) TWIST2 IL13 FOS MYC CREB1 BCL2L1 AQP4 TNF CASP3 AQP3 AHR TBP NFKB2 TNFSF10 MT1G BCL2 CYP1A1 TXNIP CSF2 JUN TGFB1 CASP8 GPR65 BAX PMC7004311__F1 One-carbon metabolism HEL-S-61p AS3MT MTR PC HEL-S-20 GAA PEMT PMC4214059__F1 A causal model specifying how genetic variation increases the susceptibility to clinical disease through smoking and alternate pathways () CHRNA5 CHRNB4 CHRNA3 PMC3344904__F1 High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC5333035__F5 Fibroblast growth factor-4 (FGF4) signal transduction pathway governs trophoblast proliferation and differentiation FGF4 APC CDC2 GMNN PMC3936609__F6 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment BAX PMC3936609__F7 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment SMAD2 SMAD4 TGFBR3 TGFB1 PMC3515920__F1 Retinoid refractoriness due to phosphorylation of retinoid X receptor alpha (RXR A), and its restoration by acyclic retinoid (ACR) in liver carcinogenesis CCND1 ACR RXRA PMC6274717__F2 IL-6 signal transduction and modes of the IL-6 receptor system STAT1 SOCS3 ARID5A SOCS1 STAT3 PMC6152498__F2 Targeting the cell cycle in breast cancer FGFR1 CDK2 TTK APC PLK4 MYC CDK4 CDC2 MTOR CDK6 PMC3145607__F5 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G1-enriched MCF7 cell cultures ANGPT2 EGR1 HOXB7 NAB1 PAQR3 PTN RPRM PTGER4 FGF13 KRT18 FGFR2 PAWR ATF4 CDH10 GNAS IL27RA PHIP BLMH JUN NKX3-1 MYLK PMC12244502__F7 Mechanism by which NEDD4L prevents colorectal cancer liver metastasis MTOR PMC3145607__F6 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in S-enriched MCF-7 cell cultures UGT1A3 MAP2 MAFF GCLC ARHGAP18 NFE2L2 FTL BTG3 ATF3 GDF1 SH3RF1 HEL60 PDZD2 S100P E2F7 ATXN1 INPP5D PKP4 NDUFA11 GNAS BTG2 JUN CTNND2 PMC3145607__F7 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G2/M-enriched MCF-7 cell cultures DNAJB4 PRKCE NPM1 PGR NBN SH3RF1 CARD6 CABLES2 CNOT1 HSF1 MPHOSPH6 MEF2D PRKCA HINT1 ANKRD29 SCAPER PDHA1 GLYCTK BAX AUTS2 NFE2L2 GSTM1 DLD DNAJB9 APBB2 OSBPL6 COX6A2 TXNIP COMP SUMO1 PMC3120109__F4 Schematic illustrating that AMPH indirectly stimulates dopamine (DA), glutamate (glu) and BDNF (B) release and stimulation of D1 dopamine, glutamate, and TrkB receptors, respectively, in the striatum RGS4 AMPH PTEN RAF1 BDNF PMC4013419__F1 Major components of Sonic hedgehog (Shh) signaling pathway SUFU GLI3 SHH SMO PMC10759521__F9 DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma CDKN1A DCAF13 RBX1 DDB1 CUL4A BAX PMC8745051__F2 ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors CDK2 RAD50 CDC2 H2AX MRE11A BRCA1 BAX PMC8060181__F1 Osteoblast role in the pathogenesis of rheumatoid arthritis BMP3 RUNX2 BMP2 MSC BMP7 SFRP1 DKK1 BMP4 PMC4238355__F7 Model for roles of microRNAs during the reprogramming process DCN TGFBR2 PMC11826472__F2 After PNI, several cellular changes are observed in the spinal cord, the injury site, and target organs GFAP TNF CSF1 PMC5315629__F3 Post-excision Events in Human Nucleotide Excision Repair POLK RAD18 PCNA PMC6881331__F7 Molecular mechanisms of p53 loss of heterozygosity in breast cancer in response to DNA damage ERBB2 MTOR HSF1 PMC3799205__F1 The leptin-induced pathways EGR1 SOCS3 GRB2 MTOR STAT3 PMC11125855__F1 Intracellular DNA sensors involved in the activation of IFN signaling and the NFKB pathway TBK1 TLR9 IRF7 IRAK1 TRAF3 DDX41 TRAF6 DHX36 IRAK4 IRF3 MYD88 TNF JMJD6 HNRNPA2B1 MAVS PMC1986651__F1 Regulation of cell proliferation and cell death by PKCE BAD PDK2 PMC2546905__F4 Predicted targets of miR-100 and miR-101 in the 3′-UTR of members of the mTOR pathway RICTOR EIF4E MTOR PMC11125855__F3 Inhibition of DNA-sensing pathways by KSHV viral proteins CGAS CARD9 IRF7 RAD50 IRF3 MRE11A AIM2 IFI16 PMC3572136__F8 Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning KDM5B SOCS3 BRAF SMAD4 RB1 TOP2A TFDP1 ING4 STAT1 E2F2 KNTC2 CCND1 MAPK1 NEUROD1 GAL ANGPT2 COL18A1 AREG FGFR3 IL6 ID1 AURKA CCK RET NEUROG3 CDKN1A STAT3 PMC9213050__F7 TLR2-mediated NFKB signaling pathway is involved in PPV1-induced apoptosis in PK-15 cells TRAF6 IRAK4 MYD88 TIRAP PMC3343650__F5 Three major signaling pathways are altered in prostate cancers EGF CDKN2C FLNA BIRC5 ERG NTRK1 CDKN1B TES RB1 CDKN2A IRS1 PIK3C2G CDK6 ERBB4 NR4A3 CYP17A1 SHC1 GNRH1 SKP2 PMC5732761__F8 Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway SRC NOXA1 PMC5431827__F8 Proposed mechanism by which HBV hijacks IFN/JAK/STAT pathway via activating SOCS2 to facilitate immune evasion and viral infection STAT1 SOCS2 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC4174315__F7 Mechanistic model depicting the factor association of DDB2 and XPC with ATR and ATM, influencing the DDR pathway in response to UV damage ATM XPA ATR PMC8126717__F2 Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia FOXM1 MYC CD44 HEL-S-104 VCAM1 IL3 ATF4 CXCR4 MSC EIF2A BCL2 MCL1 CXCL12 BAX CD36 BRD4 PMC7139330__F1 p38 MAPK activation LCK ZAP70 MAP3K7IP1 PMC4064789__F8 The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer EGF EGFR PCNA PMC6685136__F2 Wnt/Beta-cat signaling pathway ZNRF3 RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC5919976__F4 Proposed integrated model of BTN3A1 modifications induced by phosphoantigens and leading to the antigenic activation of VG9VD2 T lymphocytes PPL RHOB PMC10708146__F2 GSDMD-mediated pyroptosis in DCM NLRP3 MED12 METTL14 CGAS TLR4 IRF3 MYD88 AIM2 GSDMD SIRT3 PMC7196244__F6 An illustration of how EVO exerts anticancer activity in osteosarcoma cells through the suppressing Wnt/Beta-catenin signaling pathway APC GSK3B CDH2 PMC2856263__F6 Signaling pathways activated by DMXAA TBK1 NOD1 IRF3 NOD2 PMC9244849__F4 Disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain BAD CD37 MEI1 RAC1 BRCA1 RHEB TSC2 TSC1 BCR MDM2 SYK EIF4B RBL2 CD19 PMC6942807__F2 NRF2-mediated pathway of glutathione synthesis GCLM SLC7A11 HEL-S-64p HEL-75 SLC3A2 PRX TXN PMC5493720__F2 Changes in the methylation state of parentally imprinted genes lead to attenuation of GH/INS/IGF signaling in VSELs IGF1 IGF2 INS PMC9647096__F2 Regulatory pathway and possible targets of ferroptosis in HCC ALOXE3 FACL4 SLC7A11 FTH1 CISD1 EGFR QSCN6 GABPB1 TEAD2 GSTZ1 ATF4 MT1G ABCC5 SLC3A2 PRDX5 DAZAP1 PMC6515024__F1 Bone morphogenetic protein (BMP) signaling pathway and inhibition by Noggin SMAD4 SMAD1 DKFZp781O1323 PMC11982459__F3 Hormonal regulation of the UPR by ABA, JA, and SA HEL-S-162eP PMC4675542__F2 Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians IDO1 PTGIS MPO PTGS2 IFNGR2 PTPN6 IFNGR1 PTGS1 IRF-1 IFNG PMC7729528__F1 One‐carbon metabolic pathway MTR MTRR TCN2 MTHFD1 PMC3689245__F7 Proposed mechanism for MTX-induced melanosome transport in melanoma LCMT1 RAB27A PMC8554863__F11 CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NFKB/STAT3 signaling pathway CXCR5 DKFZp686F0183 STAT3 PMC7974894__F7 Identification of Prognosis-related Hub RNA Binding Proteins Function through Regulating Metabolic Processes in Tongue Cancer SET LEPR PFKM HIF1A FOXP3 PMC11649390__F2 Wnt signaling pathways RYK JUN PMC8523516__F1 Translational Regulation in Hepatocellular Carcinogenesis TSC2 TSC1 RHEB PMC6917511__F2 Flow chart of the RHPCG database SET YAP1 NF2 LATS1 LATS2 TF PMC6664910__F10 Schematic diagram of LIM kinase-dependent inhibition of n-cofilin activity by Reelin GSK3B DAB1 MTOR PMC11682641__F2 BCR signalling and associated pathways network, genetic resistance mechanisms and pathway adaptive resistance mechanisms to targeted therapies in CLL BTK BCL10 IRAK1 BASH LYN MYC SYK IRAK4 MYD88 CD79A ROR1 CD19 PMC11682641__F3 Detailed overview of chronic lymphocytic leukaemia's genetic landscape in the context of signalling network IRAK1 TRAF3 IRAK4 MYD88 FUBP1 BIRC2 BTK BCL10 ATM BASH BIRC3 LYN NOTCH1 BCL2 CD40 SYK MCL1 TRAF2 BAX PMC5359278__F1 Schematic diagram showing the mechanism of action of NSAIDs like aspirin in inhibiting the metabolism of arachidonic acid by blockade of the cyclooxygenases (COX) pathway and the prostaglandins (PG) synthase pathway, thus suppressing PGs synthesis COX2 COX1 PMC6472684__F2 Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction SLC7A5 MYC GRB2 JAK3 JAK1 HIF1A SHC1 PMC3853752__F3 Co-expression network of 106 genes associated to the FA metabolism in P AOX1 HEL-S-44 SP1 PMC6562400__F1 Acquisition of cysteine from extracellular cystine through xCT and de novo production of cysteine through the transsulfuration pathway CTH TXN PMC8311004__F1 Necroptosis: A Novel Pathway in Neuroinflammation RIPK1 TRADD CYLD RIPK3 TNF TRAF2 FADD MLKL PMC8531291__F6 Potential functional mechanism of SIRT3 in heat stress-induced BMECs MFN1 MFN2 FIS1 OPA1 BAX SIRT3 PMC5908872__F5 B-cell receptor signaling pathway CDS1 BCL10 BCR HEL-S-11 LYN GRB2 SHE PMC5998365__F1 Folate-mediated one-carbon metabolism MTR DHFR TYMS HEL-S-51e PMC10985914__F2 Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers CYP1B1 CYP3A4 CYP1A1 PMC1609340__F1 Outline of the TLR signalling pathway TBK1 TANK TLR4 TLR9 IRF7 IRAK1 IRF3 MYD88 TNF TLR3 TIRAP PMC8583797__F9 Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor VAV3 IGF1R SEMA4D ROCK1 ERBB2 ARHA IRS1 PMC9168746__F1 Starch metabolism in potato photosynthesizing (leaves) and storage (tubers) organs HTT GIP CP PMC4877629__F3 Genetic networks generated from the differentially expressed genes from adipose tissues FGA ITGA1 DEF6 VASP ITGA4 HEL110 GCSAM SH2D2A CD27 PAWR SIGIRR FBLIM1 CD180 DOCK3 ITGAX FANCA SWAP70 ARHGDIB ELMO1 PMC8234298__F1 Spotlight on Accessory Proteins: RTK-RAS-MAPK Modulators as New Therapeutic Targets FHL1 NCL SPRED1 SPRY1 SHOC2 RGS14 CRKL DOK1 SPRY2 CBL FLOT2 FLOT1 FRS2 GAB2 SPRED3 KSR1 FHL2 IQGAP1 GRB2 ERBIN LAT PMC9564207__F3 Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery MMP2 GC BCL2 CDK12 IL8RB SP1 UQCRC2 BAX PMC5593157__F5 The signaling pathway TSC2 TSC1 MTOR PMC6316701__F2 Effect of SUMO on IFN pathways STAT1 SUMO3 IRF3 PMC7125809__F1 IFN signal transduction cascade and defects in this pathway IRF9 PIAS1 IFNGR2 TYK2 JAK1 IFNAR1 IFNGR1 SOCS1 IFNG PMC4778363__F3 Pathway map for paramylon and wax ester metabolism in E.gracilis F2 HEL-S-5 HEL-S-162eP PMC6316701__F1 SUMO cycle PIAS2 SENP1 PIAS1 SAE1 SENP2 RANBP2 TOPORS SENP3 PMC9023181__F4 Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets SCO2 NDUFV2 SLC25A5 NDUFA6 NDUFB2 PARP1 CPT2 NDUFS3 DECR1 TNF VDAC3 COX7A2 DDIT3 TNNI3 CALM1 NDUFA5 COX7B PRKAG1 JUN COX7C ALPI COX8A SDHB PMC2756767__F2 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer HK2 PMC2756767__F3 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer IGF1R PC MTOR HK2 PMC8264607__F9 Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFB induced collagen synthesis in cardiac fibroblasts TIMP1 S1PR1 SKI PMC3857727__F3 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors NMNAT2 GSK3B FKBP5 PMC6281605__F2 Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions MUC1 NFIB RTKN FLNA TPM3 MYC ROBO4 KRT7 AHNAK VASN EIF4E CBFB INSR CLINT1 MDFI BRCA2 KLF4 MDM2 CCND1 BCL2 ABRACL F11R PMC11076713__F8 Schematic model: The interferon and interleukin 27-dependent JAK-STAT signaling pathway CGAS MHC2TA SOCS3 CCL7 CCL5 CCL2 CD74 ZBP1 STAT1 ISG15 TLR8 TLR7 TLR4 B2M AXL AIM2 IFI16 CCL8 STAT2 IRF9 SLAMF7 IFNAR2 IL6 IFNAR1 TLR3 HLA-B IL15 HLA-A SIGLEC1 IDO1 IL7 ISG20 IL27 CD40 JAK3 TYK2 CD80 JAK1 IFIT1 STAT3 PMC3857727__F1 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors NMNAT1 NMNAT2 NMNAT3 PMC6896083__F2 Schematic overview of CD147 associated partner, molecular pathway and microenvironment interaction involved in cancer progression ADAM12 SRC STAT3 PMC7195839__F4 Non-linear reverse-engineering method for inferring genetic regulatory networks RUNX1 LDB1 NOTCH1 GFI1 tal-1 LMO2 GATA2 GATA1 PMC8154043__F1 Metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis CIT MAL PMC5072731__F7 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations CTSK MAX TRAF3 TRAF6 CD40 IRAK4 MYD88 FADD PMC5072731__F8 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations CASP3 MAX ATM MYD88 BAX PMC4583193__F1 Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma EGF EMD HGF GRB2 RAC1 MTOR TGFA CDC42 PMC3001555__F1 Representation of the transduction pathway involved in Cd signaling PC CD2 TF PMC11811070__F1 Pathways to apoptosis TRADD BCL2 TNF TRAF2 FADD BAX PMC11811070__F2 Molecular mechanism of autophagy ULK1 ATG12 ATG3 ATG10 MTOR DKFZp686F0183 PMC9353186__F7 Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway IL4 ARG1 PMC3929669__F4 PPARG signaling pathway during high-altitude vs sea-level pregnancy COX2 GRB2 TRAF6 RAF1 TNF TRAF2 PPARG PMC4540190__F8 Schematic diagram outlining the novel molecular targets of CAFG leading to bone anabolic effects in osteogenic cells and fracture healing induced by BMP2/Wnt/Beta-catenin pathway RUNX2 BMP2 SOST SMAD4 DKK1 SMAD1 PMC6275309__F1 Molecular pathways of the neuro-immune hemostasis model CD59 PC CD46 FH APC CD55 PMC5430761__F9 Pathway showing role of Ror1in promoting tumor-cell growth, ERBB3 EGFR GRB2 ROR2 PTEN JAK1 CRK ROR1 STAT3 PMC10671474__F2 Common mechanisms of secondary endocrine resistance in advanced ER+ breast cancer NF1 EGFR PTEN MTOR AURKA PMC11811070__F3 The main mitophagy pathways PINK1 BCL2L13 FUNDC1 BNIP3 OPTN PHB2 PMC10671474__F1 Current endocrine and targeted treatment of metastatic ER+ breast cancer CDK4 MTOR CDK6 PMC11811070__F4 Pathways involved in necroptosis RIPK1 TRADD CYLD RIPK3 TRAF2 FADD ZBP1 MLKL PMC3154935__F4 Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury EGF SDCBP BAD MOS CRK ANGPT1 STAT1 OGA CAMK4 CXCR4 GRB2 SRC ADAM10 PXN ARAF STAT3 PMC7195839__F3 Non-linear reverse-engineering method for inferring genetic regulatory networks CBFA2T3 RUNX1 NOTCH1 tal-1 LMO2 GATA2 PMC6908489__F4 ROS contribute to ICAM-1 and PD-L1 induction in salivary gland epithelial cells through a JAK(1/)2/STAT3 pathway JAK1 IFNG STAT3 PMC8003559__F3 Activation of innate immune signaling pathway by lipopolysaccharide (LPS) and tumor necrosis factor (TNF) TLR4 TRADD IRAK1 TRAF6 IRAK4 MYD88 OTULIN TRAF2 PMC8294090__F11 Butorphanol Promotes Macrophage Phenotypic Transition to Inhibit Inflammatory Lung Injury via K Receptors IRF7 MYD88 ARG1 PMC4046121__F5A Differential Transcription of Fathead Minnow Immune-related Genes Following Infection with Frog virus 3, an Emerging Pathogen of Ectothermic Vertebrates RUNX2 NODAL PITX2 SMAD6 TRAF6 MAP3K7IP1 HDAC1 NR1i1 TLX2 SMURF2 HOXC8 GRB2 GSC SKI FOXH1 PMC10741879__F7 Schematic model showing the tumor-progression-promoting interaction between CRC cells and TAMs CCL8 LAMP2 CCL7 CCL2 MTOR HEL-S-133P PMC7071268__F3 Integrated overview of the metabolic changes induced by feeding the OBFR diet CS PC BCAT2 FH GCK OGDH PMC8146703__F6 Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study CS PC SCD PMC5581678__F2 Entanglement of GSK-3B, Beta-catenin and TGFB1 signaling network to regulate myocardial fibrosis SMAD2 APC SMAD6 SMAD4 PMC9182416__F2 Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin NOX4 BAX PMC7958144__F1 Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation SST INS GCG GLP1R PMC5819894__F2 Apoptosis pathways CASP3 BAD CASP9 CASP2 MCL1 TNF CASP8 FADD BAX PMC12009697__F2 Activation of MAPK and PI3K/MTOR signaling pathways by oncogenic FGFR2 fusion protein NF1 TSC2 TSC1 FRS2 GRB2 PTEN RHEB PMC10976388__S1 Depiction of Wnt Signaling Dysregulation in TNBC Cells When Compared to Healthy, Noncancerous Cells APC LRP5 FZD7 LRP6 BCL9 PMC3584002__F7 Model for GPN1, 2, and 3 function in biogenesis of RNA polymerases II and III XAB1 GPN3 GPN2 PMC8088470__F3 Role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells FHL1 RUNX2 IRF8 MSC IBSP ZBTB16 WNT10A CDC2 EZH2 SP7 MX1 PMC5871976__F1 Moloney-murine leukemia virus (PIM) kinases regulate cancerous pathways MYB BAD CXCR4 GSK3B MYC MDM2 MTOR PMC5871976__F2 Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway adapted from figure 2 of and figure 1 of TSC2 TSC1 PTEN RHEB PMC5871976__F3 Interrelationship between PIM, AKT and mTOR adapted from figure 2 of TSC2 EIF4E EIF4B PMC7360727__F2 Insulin signaling with highlighted in red pathways found to promote brain insulin resistance in AD and DS APP MTOR IRS1 PMC4267808__F4 The Shared Crosstalk of Multiple Pathways Involved in the Inflammation between Rheumatoid Arthritis and Coronary Artery Disease Based on a Digital Gene Expression Profile ENO1 PMC7360727__F3 Shared alterations between young DS and AD brain GSK3B PTEN MTOR IRS1 PMC5819894__F6 Metabolism pathways TIGAR SCO2 FASN PMC7090099__F3 Integrated analysis of GC-MS and LC-MS profiles DAP GIP PMC6095600__F3 Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes ANGPTL4 ELOVL6 RB1 TNF CD74 NR1C1 IFNG MAF IL18 MVD TIMP1 DHCR7 SREBF2 ACSL1 IFI35 PSMB9 SP3 STAT3 PMC3829153__F8 Molecular mechanism of DSS-induced colitis in murine model NUMB SUFU PTCH1 SHH SMO HSF2 NOD2 PMC3461102__F1 Cell-Intrinsic Innate Immune Control of West Nile Virus Infection TLR7 STAT2 IRF9 TRAF3 IRF3 TYK2 JAK1 TLR3 PMC3033173__F2 LMP1 in promoting survival in PTLD TRADD IRAK1 ATF2 RELB JAK3 PMC5233609__F3 Canonical UPR pathway ELF2 ATF4 TRAF2 PMC7137946__F1 Biosynthesis and metabolic pathway of BH4 SPR TH DHFR PAH PMC8468947__F1 Lactoferrin and Its Potential Impact for the Relief of Pain: A Preclinical Approach IL18 TLR4 IRAK1 TRAF6 IRAK4 IL6 MYD88 PMC6098163__F6 Crosstalk between RAAS and FGF-23 pathways FGF23 FGFR1 TBP TRPC6 SKI ACE2 PMC5740609__F2 Cellular processes altered by colonization by a heterologous symbiont: (A) oxidative stress response; (B) molecular signaling pathways; (C) sugar storage, transport, and signaling; and (D) lipid and protein metabolism and transport SLC16A10 FACL4 GCLC GPR161 TACR2 NAGS ABCD4 DGAT1 HEL-S-64p ACSL1 DAGLA SMO ABCD2 PMC6290060__F3 MAP of “p53 Signaling” pathway in (A) HSAEC and (B) A549 cells treated with 1 μM PG over 24 h TIGAR TH SCO2 JMY PIGS PTEN WT1 TRIM29 MON2 PERP CDK2 TOPBP1 PIAS1 MDM2 JUN PCNA P3H2 BAX PMC1174965__F4 Regulation of lipopolysaccharide (LPS) signaling by suppressor of cytokine signaling 1 (SOCS1) STAT1 TRAF6 IRF3 MYD88 SOCS1 IFNG PMC3814391__F7 DNA end resection BLM RAD51 ATR DNA2 PCNA PMC5282886__F5 Critical factors involved in IGF-IR-mediated EMT process MUC1 WISP3 PMC5282886__F6 IGF-IR signaling in CSCs-like cells biology MTOR STAT3 PMC3276974__F2 Hypothetical model of LRRK2-mediated regulation of the miRNA pathway LRRK2 EIF4E MRO PMC12055823__F4 TCM ameliorates DKD by modulating mTOR-mediated oxidative stress and nutrient sensing pathways TSC2 ULK1 MTOR SIRT1 RHEB PMC5982769__F1 B cell receptor signaling pathway in mantle cell lymphoma DOK3 EGR1 ATF2 SHE CRAT ARHA PTEN MTOR DOK1 CBL BTK BCL10 BCR BASH CD22 LYN GRB2 CD40 SYK JUN ORAI1 STIM1 CDC42 CD19 PMC7758250__F1 Immune responses elicited by Plasmodium infection NLRP3 CGAS PDC TLR7 TLR9 IRF7 IRF3 AIM2 IL1B MAVS PMC7349003__F2 Role of lncRNAs in the drug resistance of triple-negative breast cancer (TNBC) RPA1 PTEN ARF6 PMC5282886__F3 IGF signaling regulation in EMT ZEB2 GRB2 SHH PMC12055823__F2 Oxidative stress and autophagy in diabetic nephropathy TSC2 PINK1 ULK1 TSC1 MTOR SIRT1 FOXO1 RHEB STAT3 PMC7847333__F8 Schematic diagram SOST LRP5 LRP6 PMC3712008__F3 Hypothetical representation of opposite downstream effects of two signaling pathways on the G1 phase of the cell cycle in a breast tumor-initiating cell MAP3K1 IGF1R MAP2K4 CDKN2D CDKN2C PTEN RB1 CDKN1C CDK6 FGFR1 ERBB2 CDK2 CCND1 CDK4 JUN GATA3 ZNF703 PMC6172484__F4 Gene network analysis of DE genes in the infected group MUC1 PLS1 IL13 LIF IL17F CREB3L3 COL1A1 NKD1 TBX21 ATP7B THBS2 LCA5L CAPN13 GZMA IL17A IL22 ACER3 ATP2B3 PMC12055823__F1 Nutrient sensing pathway and autophagy in diabetic nephropathy ULK1 TFEB ATF4 BNIP3 DKFZp686F0183 SIRT1 FOXO1 PMC8699445__F1 Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer PALB2 ATM BRCA2 PGP RAD51 PMC5817805__F1 The BCR-ABL1 signaling pathways targeted by non ABL-directed inhibitors BCR GAB2 GRB2 BCL2 SMO MTOR SIRT1 PMC3712008__F2 Subnetwork representation of protein interactions based on 78 mutated genes in 602 breast cancers - NCOR1 ACTN2 PTEN GRIK2 MED23 DMD PMC8657692__F9 Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells EGFR FGFR4 MTOR PMC6154333__F2 Possible apoptotic pathway induced by photoactivated ZnPcSmix in monolayer cells 24 h post PDT CASP3 TP53BP2 CASP6 BAG3 BAK1 BCL2L10 BIRC3 CASP9 GADD45A TNF CASP8 BAX PMC7758250__F2 Immune regulators in anti-malaria immunity BTNL2 TBK1 TLR9 FOSL1 IRF7 TRAF3 TRAF6 BTLA IRF3 RTP4 CTLA4 TIGIT MYD88 LAG3 TLR3 TLR7 CD40 MAVS SOCS1 PMC11529444__F2 O-GlcNAcylation cycling and UDP-GlcNAc synthesis OGA OGT PMC3363007__F6 The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection APP IL1B PMC2991480__F5 FC-66 expression of the Ingenuity NFKB Signaling canonical pathway EGF LTA NGF BMP2 HEL-S-71 LCK ZAP70 PLCG2 TGFA UBE2V1 TIRAP BMP4 PMC10950925__F5 Ferroptosis Signaling Pathway GPX4 STEAP3 HEL-S-64p TF GLS PMC11085255__F1 Molecular structure and signaling pathway activation mechanism of Nrf2 KEAP1 CHD6 RXRA PMC11085255__F2 Regulation mechanism based on Nrf2 signal pathway GPX4 FYN HDAC3 KEAP1 PDK2 SIRT1 BAX PMC5966448__F6 Modeling the potential cellular roles of three genes upregulated by AnAc in MCF-7 and MDA-MB-231 cells SIRT6 ACLY PDK4 GPR176 FOXO1 PMC5662584__F4 Proposed mechanisms involved in in vitro anticancer activity of surfactin CDK2 CCNB1 AFM BAX PMC10950925__F2 Visualization of the extrinsic and intrinsic apoptosis pathway APAF1 MCL1 FADD BAX PMC4385866__F2 Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach INCA1 NRF FRK F2 NOA1 PMC1797585__F9 Working model for NS action BAD EGFR PMC6154333__F3 Possible apoptotic pathway induced by photoactivated ZnPcSmix in MCTSs 24 h post PDT BNIP3 BAX PMC138838__F1 Signaling through mammalian and Drosophila Toll-family receptors (TLRs) CD14 TLR4 LBP MYD88 PMC11085255__F3 Effects of natural products targeting Nrf2-related signaling pathway on myocardial ischemia NLRP3 SIRT2 SIRT1 PMC5613237__F4 Galactose metabolism pathway CDK2 APC GSK3B PMC6127641__F1 Possible cellular mechanisms attributed to oxidative stress in Parkinson’s disease (PD) and possible effects of natural antioxidants on specific pathway PINK1 LRRK2 ATR ROS1 PMC9561951__F2 Cellular autophagy, the compelling roles in hearing function and dysfunction TFEB GSK3B FOXG1 BNIP3L ATG9A PMC5451151__F1 Anoikis signaling pathway in cancer cells SRC PMC3710591__F7 Cellular protective response to MeHg through the Keap1-Nrf2 system MAF KEAP1 PMC8003055__F6 Proposed mitochondrial pathway for apoptosis in HCC cells induced by compound 1 BAD CCND1 CDK4 PMC7773022__F9 Proposed model of LPS/JNK/Sp1 or Nrf1 signaling pathways in regulation of TRIM59 expression NRF1 SP1 TRIM59 PMC4651715__F4 Three major signaling pathways that regulate cell size in normal cells.A TSC2 BRAF PRR5 GSK3B PTEN MTOR DEPTOR RHEB PMC8934427__F2 Interplay Between Coronavirus and Type I IFN Response STAT2 HEL-S-11 IRF9 IRF3 MAVS PMC9327801__F9 Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes HEL-S-62p SI PMC10346248__F11 Schematic models of the NRF2 signaling pathway and its regulatory mechanisms in human skeletal muscle KEAP1 C6 PMC6315839__F2 Model of biosynthesis and signal transduction of jasmonic acid (JA) and ethylene (ET) MED25 EBF2 PMC6199329__F3 miRNA-regulated pathways in preovulatory granulosa cells NUSAP1 FOXM1 FANCD2 VEGFA CHEK1 AURKB MCM3 PRC1 ECT2 CDC6 RRM2 BRCA2 HEL164 THBS1 EZH2 RAD51AP1 MSH2 PMC10145126__F2 PD-L1 regulation by IFNG STAT1 JAK1 IRF-1 PMC6199329__F4 Characterization of the miRNA regulators of the human ovulatory cascade HEL-S-62p HERC6 FOXM1 NR3A2 MMP11 GAS7 CRHBP PRIM1 SOX4 HES1 PLXNC1 TU3A GSE1 THBS1 MFAP2 ACAN MSH2 GLCE CSPG4 PPIE CD47 VEGFA CHEK1 DAAM1 NR4A3 TYMS LOXL1 PMC3573791__F1 The metalloproteases meprin A and meprin B: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis EGF FURIN PMC3696550__F6 Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia PIK3CD PIK3R1 PPP3CA PPP3CC MAPK3 GSK3B TEC NCK1 IFNG VAV3 BCL10 BCR GC MAPK1 FCGR2B CSF2 SOS2 FOS VAV1 APC MAP3K7 CTLA4 TNF PIK3R3 PIK3R5 PAK1 PPP3R1 NFKB2 BIK GRB2 LAT NFKBIE AKT3 CHUK NFATC4 NCK2 CD81 CDK4 JUN CD3E CD19 NFATC1 ARHA NFATC3 IKBKB CARD11 NFKBIA NFKBIB NFATC2 RASGRP3 NFKB1 CD22 PIK3CA RAF1 SOS1 VAV2 PIK3R2 PMC10527328__F1 Exploring the Molecular Landscape of Myelofibrosis, with a Focus on Ras and Mitogen-Activated Protein (MAP) Kinase Signaling NF1 BRAF GRB2 HEL-S-99n MPL CBL PMC9476673__F3 Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis SLC7A5 CS ABCG1 OGDH ABCA1 HK2 PMC2634987__F1 The GEP100-Arf6 pathway to invasion EGF EGFR ARF6 PMC12248877__F1 PI3K/Akt/mTOR signaling pathway and the respective inhibitors used in TNBC PTEN MTOR PMC3128624__F6 NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease DNAJB14 MAFF FOS RELA JUND MAFG PMC7368075__F2 AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network KIF23 MARCKS GSK3B AHNAK MYH10 ARHGAP35 TAOK1 NF1 FGFR1 PALLD SNTB2 ATXN2L ARHGEF17 DOCK9 NCL LARP6 PLEC APC RAB10 TSC2 ARHGAP31 NEDD9 WASL SGMS2 RRAGD SDCBP LMOD1 ARAP1 HSF1 EPHB4 STARD13 STK10 ARHGEF40 LPP LPXN RBM26 SIPA1L1 RALGPS2 CDC42EP2 IWS1 INPPL1 RBM15B SCAF1 DENND4C SORBS3 MYO9A EHD2 OPHN1 FLOT2 SMG1 TRIM28 SLK DOCK2 DOCK7 NBN PNN RBBP6 TRIP10 SSH3 PHACTR4 HEL114 RPS27 AXL SVIL TRIO RBM17 AKAP12 ARHGEF7 TUBB DPYSL3 DOCK1 CRK CORO1C ADAR ZYX PHACTR2 GRB2 HEL113 DENR MYLK CLASP1 TH RPLP2 GEM PEAK1 EGFR DST ARHGEF2 TNK2 LEO1 RIPK2 LIMD1 ZC3HAV1 RANBP1 PRP4K PTPN1 PCBP1 ARHGAP29 APBB1IP RAB13 RPLP0 NTRK3 SCRIB SYNPO2 NUP153 CPEB4 PKP4 PIK3CA PXN FRMD6 PMC3439136__F3 Additional analysis of the PPI network RPL32 RPL37A EGFR RPL27 RPL6 RPL30 MCM7 RPL9 RPL23A RPL17 RPS18 RP1 RPS20 RPL3 PMC7375918__F4 Emerging Functions of Lactate in Regulating Signal Transduction and Gene Expression TBK1 NDRG3 VHL IRF3 MAVS PMC3439136__F4 Dynamics in the RTK-Ras-ERK signaling network RPL37A RPL37 RPL23A PMC8484535__F1 Small RNAs: The Essential Regulators in Plant Thermotolerance AGO1 AGO4 ORM2 PMC6498879__F6 Comfrey’s mode of action by interference with the NFKB signaling pathway PTMS IRAK1 TRAF6 IRAK4 MYD88 PMC3439136__F2 TAP-MS PPI RTK-Ras-ERK signaling network HDAC3 EGFR RPL27 RPL9 RPS26 RANBP9 RPL23A RPS18 TBP RPL21 RPS27 RPS20 RPL3 CCS RPL32 RPL37A HEL-S-310 RPL6 CDC37 RPL30 RPL15 RPN1 TARP RFC4 RPL17 TCP1 RPL28 GAPT PMC3875667__F2 Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival CDK2 PMAIP1 MSH2 PMC7852227__F7 Schematic diagram FOXC1 TH CTH DNMT3B PMC8863324__F1 Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives APC DES PMC7979537__F8 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling SOX2 CHRNA7 STAT3 PMC3011046__F2 FAS generates an endogenous ligand for PPARA in liver CEPT1 NR1C1 PMC4039369__F1 Yeast pathway map of nucleotide degradation and ribose salvage HEL-S-49 PGM3 tal-1 PMC2921256__F1 Biology of the von Hippel-Lindau/hypoxia-inducible factor (VHL-HIF) axis in the setting of hypoxia or a mutation or aberration of the VHL gene product EPO EGFR VHL BNIP3 MTOR TGFA PMC4930294__F2 Signaling pathways important for stem/progenitor cells regulation ZNRF3 ATOH1 APC ADAM10 RNF4 GPR49 PMC5271588__F6 Cross-talk between apoptotic pathways FADD BAX PMC4345829__F5 MicroRNAs (miRNAs) and autophagy (adapted with permission from Ventham et al, Gastroenterology) ATG16L1 TLR4 IRGM NOD2 PMC1683566__F5 Integration of gene expression with the proposed mechanistic pathway initiated by comfrey treatment leading to tumorigenesis CCR2 ABCC3 EGF MAPK9 HGF HMOX1 CYP7A1 CCNE1 IER3 MMP2 opn APP GSTA3 KRT5 KRT4 GSTM3 NOS2 GJB1 S100A4 PLAUR LIF XPC ATF3 ADRB2 GADD45A KRT7 KRT2 HEL-S-22 EDN1 TIMP1 KRT3 IGF1 CDKN1A UGCG TNFSF10 ABCC1 ABCB9 BCL2 ITGAV TGFB1 INHBA COL4A2 PMC6571000__F6 T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection EGF PPP3CC CSF3R IL1R2 IFNGR2 CARD6 CSF2RB NCR3 HLA-DMA ITK NOG FYN VAV3 IL18 PDGFA CD2 IL17RA CD40LG CD3G IL1B ICOS CD3D CXCR1 gdf7 E2F5 PLEKHO2 IL8RB PIK3R3 SH2D1A ID3 PSTPIP1 IL10RB CARD9 ITGB7 ITGA6 SMURF2 TNFRSF1A LCK CD22 ZAP70 IL18RAP PYCARD INHBA IL18R1 PMC9599362__F3 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells TLR9 IRAK1 TRAF6 IRAK4 MYD88 MTOR CD79B CD79A CARD11 BCL10 BCR CD40 SYK PMC11786704__F6 Schematic illustrates the signaling pathways involved in wound repair GCGR COX2 PC GCG JUN BAX PMC9599362__F1 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells BCR RELA RELB LTBR PMC10454712__F2 Diagram of genes and metabolite pathways associated with the major secondary metabolites of tea plants GC APRT GCG PMC7866651__F8 Diagram of regulated pathway in liver of GIFT exposed to acute hypoxia stress after 96 h HEL-S-102 HEL-S-278 INS ELOVL6 TG INSR PMC6078353__F4 KEGG pathway functional analysis of differentially expressed genes VASP BAD HEL-S-28 ARHA DOCK1 PTEN CRK PMC4890891__F3 Regulatory network of Katanin protein LECT2 SKP1 NEDD8 DYRK2 PMC7856673__F1 Current model of LOX-1-dependent signal transduction ROCK2 ARHGEF1 VCAM1 SRC ARHA CXCL2 PMC5042386__F1 Schematic overview of the Hippo signaling pathway TEAD3 TEAD4 LATS1 MOB1A TEAD2 PMC5042386__F2 Regulation of the Hippo signaling pathway in mammalian cells TEAD3 PATJ MPDZ AMOT NF2 APC TEAD4 LATS1 RHO LATS2 TEAD2 PMC5390871__F9 Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1 PC HEL-S-11 LPA PMC6548759__F3 Results of Pancancer Pathway Panel analysis BAMBI E2F4 NODAL PITX2 TGFBR1 SMAD4 SKP1 ARHA RBX1 LTBP1 IFNG FST THBS1 SP1 PMC3032410__F7 Dynamic Distribution of CARD11 at the Immunological Synapse is Regulated by the Inhibitory Kinesin GAKIN CARD11 APC TRAF6 PMC4212018__F1 Adaptive resistance to RAF inhibitors in melanoma BRAF ERBB2 ERBB3 EGFR NRAS GRB2 PMC9130585__F2 Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation MYH9 PCM1 SUFU PTCH1 BBS4 EGFR SHH CEP131 IFT27 CEP290 OFD1 NR1H4 PMC7166181__F3 Signaling Pathways Regulated by PI3K/Akt/mTOR that Promote Neuritogenesis: A variety of ligands lead to neurite initiation and elongation through PI3K/Akt/mTOR signaling RICTOR MAP2 HGF NGF ROCK1 APC GSK3B ATF3 RAC1 MTOR BDNF CDC42 PMC7382367__F3 Role of methyltransferase-like enzyme 3 and methyltransferase-like enzyme 14 in urological cancers LEF1 METTL3 CCND1 ITGB1 PMC7407959__F1 Surgery and temporal sequence of icv HEL-S-11 CA3 PMC4156265__F5 Pathway analysis LTB PGC PMC3118704__F3 Toll-like receptor-4 (TLR-4) signaling via MyD-88-dependent pathways CD14 EGR1 TLR4 LBP TRAF6 MYD88 PMC6663492__F1 Pathways that may impact radiosensitivity EGFR PTEN MTOR PMC3367558__F1 Wnt signaling pathways MAP1B APC GSK3B ARHA RAC1 DKK1 PMC6528674__F3 Non-canonical Hippo signaling in the regulation of leukocyte function IL17A DENND1C RAB13 STAT3 FOXP3 PMC3367558__F2 Wnt signaling at vertebrate neuromuscular junctions WNT3 PAK1 MUSK APC RHO RAC1 PMC10992393__F1 De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica TES CIT HDC PMC6528674__F4 Non-canonical Hippo signaling in the regulation of leukocyte function TLR4 RAB27A MYD88 TLR1 PMC3367558__F3 Negative regulation of AChR clustering by Wnt3a WNT3A GSK3B PMC4001841__F1 PI3K-AKT pathway and associated cellular activities PI3 BAD GSK3B MDM2 SRC EIF4E PMC3772101__F1 Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway STAT1 ISG15 MED14 STAT2 IRF9 PMC9368934__F2 Stem Cell-Based Therapies for Inflammatory Bowel Disease MAF MPO KEAP1 PMC9693551__F1 Modulatory Effect of Chlorogenic Acid and Coffee Extracts on Wnt/Beta-Catenin Pathway in Colorectal Cancer Cells APC GC EGFR GSK3B CD44 CCND1 CGA GPR49 PMC6528674__F1 Non-canonical Hippo signaling in the regulation of leukocyte function LATS1 LATS2 PMC7927447__F2 Action of targeted therapies in PIRDs APC PTEN PMC5079521__F1 Physiological mechanisms and therapeutic potential of bone mechanosensing RUNX2 PKD1 PMC5672004__F8 Pathways summary showing identified kinases in BTV infected cells BAD PLK3 EEF1A1 PMC5313049__F9 Genome evolution in the allotetraploid frog Xenopus laevis PLK1 CDKN2D CDKN2C CCNH MOB1A MOBKL1A CAPZA1 LATS2 CCND2 NF2 TEF CRB3 CDC2 COX7C YAP1 CDKN1B APC SCRIB CDC25B TNLG7C FAM50A HEL-S-31 AURKB CCNB3 UBE2C CDC20 CDKN2B CEND1 CCNB2 CRB2 PMC2387053__F2 Aging of the brain, neurotrophin signaling, and Alzheimer’s disease: is IGF1-R the common culprit? IGF1R IGF1 PTEN PMC4055761__F3 Chromatin Remodelling Induced by the Freshwater Cyanotoxin Cylindrospermopsin in Human Intestinal Caco-2 Cells SPAG7 MED10 DKFZp781B1423 EXOSC8 ELP4 SLMAP POLR3E RNASEL FHOD1 MTF1 UBE2W PNO1 MEAF6 DDX3X UHRF1 PPP2R1B KRT18 LRRC47 MED21 EPC1 MTMR3 HELZ RNF114 BAT2L DUSP16 EVI1 BTG1 CCNL2 SMN1 MED6 PMC8527892__F2 Plasmin Cascade Mediates Thrombotic Events in SARS-CoV-2 Infection via Complement and Platelet-Activating Systems PROS1 SOCS3 CXCL5 CXCL3 FLNB SAA1 IL6R SPRR2E KRT6B S100A7 STAT1 ALOX15B VAV3 OAS3 TCN1 KRT4 IFNGR1 SERPINB2 PRSS23 ITGB3 IRF7 IRF9 HBEGF ADRB2 CTSH BCL2A1 PARP12 CYP4F3 CCL20 TNFRSF10A CXCL1 OTUB2 IFITM3 POU2F2 HCAR3 MX2 MX1 DTX3L OAS1 XAF1 OAS2 PPARGC1A CXCL6 VNN1 ANXA1 CFB SERPINB8 KRT75 SPRR2D KRT24 NFKBIA TUBB4B EPHA2 NCF2 SPARC ADAM8 IRAK2 TRAF3 CSTB RHOV IVL SLPI IFITM1 G0S2 P2RY6 SPRR2A TNFSF14 TIMP3 CSF2 LY6D PLAUR LTB FOXO1 IFI44 TNC TUBA1A HELZ2 TGM1 TUBA1B RND1 TNFAIP3 UBE2L6 IFIT1 IFIT3 HEL-S-62p CDA IKBKE TUBA4A CSF3 GBP5 TYMP KRT23 CXCL16 CD109 PLAT IER3 TUBA1C BASH BIRC3 LDLR B4GALT1 EPHA4 CTDSPL LIF BST2 PTGS2 CXCL2 IL6 NRP1 MAP3K8 RHOF INHBA PMC4590607__F3 Functional architecture of AXAN ATG3 EIF3A PRKAA1 ATP2C1 SAFB GOSR1 LYST PRKAG3 PRKAB1 ATG12 RPL35 RPN2 STRADA SAFB2 GABARAPL2 EDEM1 FARSB STK11 PRKAG2 RB1CC1 VPS33A ULK1 VPS16 GDA VPS18 VPS33B ULK2 RHO MTOR DKFZp686F0183 RPTOR CKAP4 VPS39 MAP1LC3B2 GABARAPL1 GABARAP ATG16L1 RPL13a PRKAA2 GYS1 AKTIP ATG10 CAB39 USE1 MAP1LC3C ATG16L2 TP53INP2 SRM ASNS ECHS1 DDOST STIM1 AGL CAMKK2 RAB24 PMC6373340__F5 Insulin resistance mechanism and potential sites of vanadium activity CS PTEN ELOVL6 LPA RHEB TSC2 TSC1 PC F2 PKLR GRB2 UNK CD36 PMC7756379__F5 Proposed pathway for gladiostatin biosynthesis REL AMT PMC5584733__F3 Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms RCE1 RAC1 IPP PMC7174042__F1 Primary motor neuron components and lipidome pathways in MND/HSP CYP46A1 CYP11A1 CYP7B1 PISD CYP7A1 HSD3B7 CYP27A1 CH25H PTDSS1 PC DDHD1 CYP3A4 CHKA PNPLA6 PCYT2 PTDSS2 PMC7174042__F2 PE and oxysterol pathways and the mitochondria-associated ER membrane (MAM) VAPB CYP7B1 PISD TRIAP1 CYP27A1 MFN2 PTDSS1 PC CHKA PNPLA6 REEP1 CYP2U1 PCYT2 PTDSS2 PMC9104818__F5 Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells SPARC SORCS2 IFFO1 HERC2 SRI KBTBD11 CCPG1 EPO NGF MOAP1 POSTN SMAD2 SMAD4 HSPD1 TNFSF13 SYNGAP1 CTGF VAV3 NR1i1 HEL-S-2 EPHX2 BNIP3L TPP1 HK2 KIRREL3 PTBP1 CPNE1 VEGFA UXS1 KDM3B PTPRN COMP EHHADH CD36 SLC36A1 HEL-S-62p CHUK TMEM30A SGPP1 STYX SEMA4C GPX1 INS CFL2 C4A CACNA2D1 CXXC4 MX1 ATF4 CLP1 XDH DLGAP2 RASSF2 TTYH3 SLC24A3 RUNX1 DEPDC5 SHANK1 DBT NR1C1 ITGAM FAM20C ADAMTS4 ZC3H11A CREBBP PIM3 PITPNM2 SDC4 MRC2 AHSG ECM2 PLOD3 NFIL3 TMEM184A ESPN SPG11 TNFAIP2 NARS1 TRAM2 PLEKHG2 RAN RALGAPA2 OTUD5 TUBG2 SHC1 PCNX3 TGFBI RPP40 PMC8961331__F3 Interplay Between TGFB Signaling and Cell Metabolism SGMS1 SPHK1 PMC9658815__F6 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications TNF NQO1 PMC8961331__F4 Interplay Between TGFB Signaling and Cell Metabolism AMD1 ARG1 PMC9658815__F5 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications POMC TYRP1 PMC9658815__F2 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications SMAD2 SMAD4 PMC4360697__F2 Underlying link between Alzheimer’s disease and type 2 diabetes mellitus.Notes: Insulin resistance reduces the degradation of AB by IDE, and makes the combination of insulin and insulin receptor impaired BACE1 GSK3B APP PMC5507898__F8 Hypothetical model for the role of ASXL1 in cell cycle progression through the cooperation with AKT1 and EZH2 CDK2 ASXL1 EZH2 PMC9696306__F6 Screening for Hyperthermophilic Electrotrophs for the Microbial Electrosynthesis of Organic Compounds MTR AACS HBD FH MME PMC5846498__F2 Novel bacterial ADP-ribosylating toxins: structure and function EGF HBEGF PMC7607069__F14 PPI network of TP53 signaling pathway genes (GeneMANIA) THAP10 NPAS3 DKFZp781B1423 MDC1 RBBP6 TP53BP1 UBE2A RPL11 PEX19 CDKN2AIP SMURF2 MDM2 TP73 RPL5 CUL9 WWOX ELL PMC3521201__F1 Central carbon metabolism pathways in E CIT HPR GALP PMC4276873__F7 Tpl2-ERK activation during TLR signaling CD14 TLR7 TLR4 TLR9 SYK MYD88 TLR3 TIRAP PMC7589016__F2 Intracellular signaling cascades activated by interaction of BDNF isoforms with its receptors TRAF6 ARHA PTEN PMC11684189__F1 Cholesterol metabolic pathway ABCG8 ABCG5 LPL LDLR NPC1L1 ABCA1 ABCB11 TG HMGCR CYP7A1 PMC8609078__F6 CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway GRB2 CD200 JAK1 PMC3917357__F1 Functional properties of ion channels and transporters in tumour vascularization TRPV4 TEC PMC8173049__F7 Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes NLRP3 RIPK1 TLR4 LBP RIPK3 MYD88 TNF IL1B TIRAP GSDMD PMC3640917__F4 Pathway for Death receptor signalling at 24 h post-M TBK1 TRADD DIABLO TRAF2 FADD PMC7982480__F1 Neuroprotective effects of ghrelin in PD WNT3A WNT1 IL1B UCP2 BAX PMC4739739__F3 Connectivity of differentially expressed genes in the important signaling pathway following mixed PCBs exposure in human PBMC in vitro depicting the connectivity between genes expressed (with ≥1.5 fold change, t-test, p <0.05) RBMS1 CCNA2 MAPK9 KEAP1 ING3 VPS37C EMP3 PHKA2 UHMK1 TRIB2 DHPS BCR STX4A NFYC AXL MYCBP2 TES TNPO2 GUK1 IFNAR2 VPS28 LMNA PGRMC1 SNAP23 TK1 SRSF9 YWHAQ NFKB2 ZNF217 RBBP7 GRB2 HBB STK11 GABPA ATP2A2 GNB1 CP GLS PARP10 RELB MORC2 WTAP MEF2D DPP3 HTATIP2 PKP2 JUP PRKDC SACS VPS37A CYP11A1 MAP2K2 RPL15 SUZ12 EED ALPL RELA GNAS VPS37B AGAP2 MYT1 PMC10855599__F2 JAK-STAT signaling pathway and PI3K-AKT signaling pathway that affect AD IL13RA1 TYK2 JAK1 IRS1 STAT3 PMC2796182__F4 Regulation of nitric oxide signaling by thrombospondin-1: implications for anti-angiogenic therapies CD47 FYN FGF2 SRC LPA CD36 PMC6755424__F7 TGF-ß signaling pathway BAMBI FST NODAL TGFBR1 SMAD4 SKP1 ARHA THBS1 TNF RBX1 IFNG PMC2745153__F2 Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling EGF HEL-S-28 RHO STAT3 PMC5697091__F10 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C HEL-S-62p F10 TFPI CS F8 CPB2 C9 A2M F2 F3 C7 VWF F11 C6 CR2 PMC6048758__F4 Regulation of SREBP1 and lipid metabolism by oncogenic signaling EGF EGFR FGFR3 CDC2 ACLY FASN PMC8910032__F6 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis ZAP70 MAP3K7IP1 STAT3 PMC7672342__F3 Tuberous sclerosis: a review of the past, present, and future TSC2 TSC1 TBC1D7 DEPTOR RHEB MLST8 PMC5473728__F1 Schematic Overview of the Norrin-Beta-Catenin PathwayMutations in the genes encoding the ligand Norrin, the receptors FZD4, LRP5, and TSPAN12, and now the transcriptional activator Beta-catenin all cause FEVR TSPAN12 APC LRP5 FZD4 PMC5614322__F2 Hypothetic pathogenesis of OPLL RUNX2 MSC SOX9 PMC6134417__F1 抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用 IGF1R EGFR MTOR PMC3296959__F2 Innate immunity and the ubiquitin–proteasome system in PD ISG15 LRRK2 ATM PMC8210559__F5 HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer SOX2 EZH2 CDH2 HOXA5 SUZ12 EED PMC2849832__F1 IFNG signaling through the JAK/STAT1 pathway STAT1 CDKN1A IFNGR2 JAK1 IFNGR1 PSMB9 IRF2 IRF-1 PSMB8 IFNG PMC8910032__F3 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis ATM CDK4 H2AX CDK6 BAX PMC7369353__F1 Main mechanisms of Wnt/Beta-catenin and PI3K/AKT/mTORC1 pathway interconnections TSC2 APC GSK3B AXIN1 LRP5 CCND1 LRP6 EIF4E AXIN2 DEPTOR TCF4 PMC3750403__F3 BIOBASE-derived signaling network centered on p38 MAPK FECH TLR4 FOXO3A PHC2 MYC GPSM3 CREB1 TF PMC9105968__F5 Lactoferrin as a Human Genome “Guardian”—An Overall Point of View CDK2 CDK4 CDC2 MTOR CDK6 PMC6390476__F1 Schematic overview depicting regulatory pathways for PYY and GLP-1 secretion by enteroendocrine L-cell FFAR3 PYY FFAR2 FFAR1 GPR119 PMC3480485__F5 Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line RAD1 ATM BLM MSH6 BARD1 ATF1 ATR IFNG PMC9319477__F6 Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcERI Cross-Linking FCER1G MAP2K6 PMC6351700__F2 Signaling model in a cell during tumor formation TSC2 OAF MTOR RHEB PMC6351700__F3 Schematic/proposed signaling model of role and regulation of claudins in a cell during invasive or metastatic stage TSC1 APC EGFR LRP5 SRC LRP6 TNF MTOR RHEB PMC9236612__F8 Growth arrest and TRIM37 growth arrest activity PLK4 CNTROB ANKRD26 TRIM37 PMC11088339__F5 Therapeutic application of adipose-derived stromal vascular fraction in myocardial infarction CCR2 SMAD2 TRAF6 CCL2 MTOR PMC7537941__F2 Activation of the coagulation cascade and endogenous anticoagulants TFPI PLG APC TNF TF PMC11088339__F2 The transforming growth factor B (TGFB) signaling pathway in cardiac fibrosisTGFB regulate phenotypes of the cells through activation of mothers against decapentaplegic (SMAD)-related pathway together with p38 pathway SMAD2 SMAD4 PMC4000463__F1 JAK2 receptor signaling and activation of STAT pathway EPO MPL STAT3 PMC5478092__F5 Metallothionein roles in aging and reactive oxygen species ATF7 PMC8398928__F1 Current Therapies in Clinical Trials of Parkinson’s Disease: A 2021 Update PINK1 LRRK2 HEL-117 PMC6879750__F5 Conserved and novel homologues of bilaterian genes involved in axis patterning and regulated by the Wnt/Beta-catenin signalling pathway in Hydra RUNX2 ERG GSK3B IRX6 DMRT3 DLX1 TLX1 LMX1B FOXB1 LEF1 NKX2-1 SOX30 VSX2 ARX OTP GATA3 PMC3636756__F1 Two kinases are required to promote mitotic entry WEE1 CDC2 MYT1 PMC11597433__F4 Wnt signaling pathway [04310] BAMBI RNF43 APC SOST NOTUM LRP5 CER1 SMAD4 LRP6 CCAR2 NLK MCC SIRT1 PMC6944532__F3 Representative Examples of Gain-of-Function (GOF) Mutations That Perturb Signaling Pathways CACNA1H IRS1 TERT PMC7198026__F2 Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges PIM1 SRC BCL2 STAT3 PMC5591914__F5 5-HT2A receptor antagonist contributing to DM-induced cardiovascular complications VCAM1 RHO PMC3636756__F2 Two hypotheses for Gwl activation and mitotic entry WEE1 ARPP19 MYT1 PMC3636756__F3 CSF arrest is the result of a tight balance between PP2A-B55 and PP2A-B56 ARPP19 APC CDC2 PMC5591914__F1 5-HT biosynthesis and metabolism in peripheral tissues TPH1 PC TPH2 PMC2671376__F7 Signaling in the PI3K/Akt pathway and deregulations detected in GRMD skeletal muscle PTEN MTOR PMC10850268__F1 Signaling pathway of insulin action and the selective impairment of insulin receptor substrate (IRS)-protein kinase B (Akt) signaling pathway in insulin resistance MTOR IRS1 FOXO1 PDPK1 CD36 PMC7154126__F1 Interplay of glycolysis pathway with EMT factors HK3 HGF ENO1 HEL-S-87p HK2 PMC3046639__F1 RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it NF1 CS BRAF GRB2 SPRED1 SHOC2 RAF1 SOS1 HRAS CBL PMC7830359__F1 Network of differentially expressed genes prior to initiation of anti-TNF therapy based on interactions using Ingenuity Pathway Analysis OASL MAP2K1 MAP2 GNLY KLRD1 IFITM3 EPSTI1 HK2 HLA-C PMC6467501__F1 Xs and Y of immune responses to viral vaccines IRF7 TRIM2 CD44 TRIM25 CREBZF MX1 IL15 ISG15 HLA-A OAS2 TLR7 XCL1 ATM ISG20 HEL-S-2 IVNS1ABP ADA SRC AIM2 IFI6 PMC7093136__F5 Summary of signaling pathways and molecular events induced by Chlamydia to promote inclusion development and EMT induction, leading to complications EGFR SMAD4 TAC3 TGFBR3 PMC8144171__F4 Functions and Targets of miR-335 in Cancer TSC2 TSC1 PTCH1 GLI3 SHH SMO LATS1 MTOR LATS2 RHEB PMC2993607__F1 RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? CDC6 MYC CDK4 BMI1 CDC2 CDK6 PMC5372562__F2 Interaction and localization of proteins belonging to the integrin signaling pathway and found in samples 2 and/or 3 MAPK8 MAPK3 GSK3B NRAS RALA CRKL NCK1 RAP2B PFN2 MAPK1 HEL114 ACTR2 RALB HRAS ARPC4 ARHG RAC3 RAP1A ARPC2 ARPC3 WASL ZYX GRB2 RHOT2 MYLK CDC42 PLCG1 VASP BRAF ACTA2 PAK4 TLN1 PFN1 TTN PARVA TLN2 ATM ARF4 RHOB RRAS ARHA RAC1 RRAS2 ARF1 PS1TP5BP1 RHOF ARF6 ACTR3 PXN PMC5372562__F3 Interaction and localization of proteins, belonging to the angiopoietin signaling pathway and found in samples 2 and/or 3 CHUK IKBKG BIRC5 RRAS PAK4 RRAS2 HRAS PAK1IP1 PIK3R4 NCK1 IKBKB NFKB2 ATM NFKB1 PTPN11 GRB2 PIK3R2 PMC7581770__F1A Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease BMP6 MAP2 MMP9 TGFBR2 VEGFA VEGFC APOB KDR MMP2 TNFSF11 ANXA2 APRT CR2 TGFBR3 TF PMC7472741__F2 SREBP-regulated mevalonate pathway and its regulation SQLE PMVK DHCR7 EBP SC5D LDLR MVK REST ARHA HSD17B7 TM7SF2 IPP PMC9586216__F1 Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression SUFU SHH SMO PMC7504523__F5 IFN signaling pathway suppressed by ADAR1 via the miR-302/367 cluster IRF7 IRF9 IRF3 TYK2 JAK1 IFNAR1 MAVS PMC8958723__F3 In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models TSC2 RICTOR BAD GAB2 GRB2 PTEN MTOR IRS1 RHEB BAX CBL PMC2730524__F3 Translating insights from the cancer genome into clinical practice ERBB2 EGFR MYC PTEN BRCA1 PMC4939383__F1 NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation ATG16L1 NOD1 TRAF2 XBP1 NOD2 PMC2812679__F8 TK-mediated signaling pathway promoting HaCaT keratinocyte migration EGF SRC HBEGF PMC8897153__F1 Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma HMGB1 PC FBP1 ENO1 RPIA HEL-S-87p HEL107 PGAM1 PHGDH HK2 HEL-S-68p HEL-S-162eP PMC5405564__F6 Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions DYNC1H1 HEL-S-62p CCT8 LOXL2 HSPG2 PLEC LAMA3 TF FASN PMC5449464__F4 Signaling and crosstalk associated with relaxin activation of its receptor RXFP1 GC PMC7456455__F1 Monocytes represent a window between bone marrow and tissues CD14 CSF1R CSF3R CD40 IFNG PMC7422850__F4 Anti apoptotic effect of curcumin FADD BAX PMC12255454__F6 The sphingolipid metabolic pathway and biochemical tools for its investigation SPTLC1 DGAT2 ORMDL1 FADS3 DGAT1 ORMDL2 ORMDL3 ACER1 CERS3 ACER3 LASS1 SPTLC2 CERS5 KDSR CERS2 PMC12255454__F7 Metabolic building blocks within the sphingolipid pathway and their subcellular localization GLTPD1 CERT1 ACER1 CERS3 ACER3 LASS1 CERS5 CERK CERS2 PMC12255454__F8 Pathway map for individual molecular subspecies of sphingolipids beginning from production of the sphingoid base backbone through subsequent metabolic steps, emphasizing key branchpoints (nodes) NODAL FIG4 CER1 CERS3 CERS2 HEL-S-5 PMC4151463__F9 Function of integrin linked-kinase (ILK) in normal and activated stellate cells–implications for fibrogenesis in wound healing HEL-S-28 RHO CDC42 PMC5824489__F3 Sirtuins in Antioxidant and Redox Signaling SIRT2 SIRT7 NOLC1 AACS NEGR1 SIRT6 HCRTR2 SIRT1 SIRT3 PMC11316721__F2 Molecular mechanisms of RBP4 in pancreatic Beta-cell function STAT1 RBP4 PMC8470622__F3 Epidermal Growth Factor Receptor Expression in the Corneal Epithelium EGF BTC HBEGF TGFA PMC7186717__F2 Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment CD80 PMC9131283__F8 5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression SMAD2 SMAD4 STAT3 PMC3735202__F3 Schematic diagram showing the Ras signalling pathway and its linkage to the GTPase cellular motility axis (Reproduced with permission from) EGF BAD RHOB PMC8076293__F3 NFKB signalling cascade CGAS RELA TRAF3 RELB REL TRAF2 MAVS PMC7003279__F5 Genes of differential proteins in the interaction network NPNT CD46 APOC3 TFRC NME2 LPA UMOD CR1 HMFT1766 SEMG2 SEMG1 PGP LDLR CD55 ABCB1 APOA2 APOE CHGB HFE PSAP HRAS APOB RAP1A PDGFRL RAF1 APOH ABCA1 HEL-S-93 TF PMC7016816__F1 Schematic view of the ferroptosis pathway GPX4 FACL4 SLC7A11 HEL-S-64p TFRC SLC3A2 PMC10030510__F2 Metabolic regulation of dendritic cell activation and immune function during inflammation CPT1A MPC1 HEL-S-133P HK2 FASN PMC6617704__F7 Illustration of IPO5 involvement in CRC CCND1 BCL2 CDK4 IPO5 CDK6 BAX PMC9023807__F3 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer GSK3B PIK3CA PTEN RAF1 PMC11316721__F1 Molecular mechanisms of RBP4 in insulin resistance TLR4 MYD88 IRS1 PMC9023807__F1 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer CDH2 PMC10030510__F4 Metabolic regulation of dendritic cell activation and immune function during inflammation TBK1 MTOR HK2 PMC9023807__F2 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer TGFBR1 PMC5409774__F5 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) BAD NGF TRADD ATM IL3 APAF1 HEL-S-11 MYD88 TRAF2 FADD BAX PMC5409774__F6 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) DCT TYRP1 PMC5409774__F7 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) CD14 CTSK TLR9 TRAF6 IRAK4 IRF3 RAC1 TLR3 CPO LBP CD40 FADD TIRAP PMC5031334__F6 Proposed biosynthetic pathway for ATM PC ARTN ART1 ACR PMC2756538__F3 A model for the role of eEF-2K in the induction of autophagy during amino acid starvation and ER stress EEF2K EEF2 EIF2A PMC5661117__F8 Hippo pathway in mesothelioma cells NF2 AREG LATS1 RHO LATS2 PMC3328790__F1 TGFB signaling pathway and its integration with other major pathways that is likely to be involved in the pathogenesis of cardiovascular diseases in elderly patients RUNX2 SMAD2 TGFBR1 TGFBR2 SMAD4 TGFBR3 PMC5508596__F1 Wnt signaling pathways.(A) The canonical pathway is activated once Wnt binds to the frizzled (FZD) receptor and LRP-5/6 co-receptor, thus recruiting disheveled (DVL) protein that inhibits the Beta-catenin destruction complex APC LRP5 LRP6 RYK RHO JUN PMC4937870__F6 Activation of IL-8 and cyclin D1: proposed POP mixture pathway shared by inflammation and cancer AHR CREB1 CCND1 PMC4855182__F6 Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling RUNX2 BMP2 MSC PMC7676939__F3 Androgen effects on the adrenergic system in the airway smooth muscle (ASM) KY PMC4224073__F1 Complement system: an overview HEL-S-62p C9 C4B_2 PLG CRP C7 C6 C1S C4A PMC4069674__F1 Suppression of metastasis by mirtazapine via restoration of the Lin-7C/Beta-catenin pathway in human cancer cells LIN7C APBA1 CASK DLG4 PMC3460211__F3 Formaldehyde-responsive miRNAs predicted to modulate MAM-associated genes in the brains of Mgmt−/− mice RFC1 CAMK2D GNPDA2 NTS TXNIP EPHA4 PMC8815368__F3 BIRC5 was significantly enriched in the apoptosis pathway CASP3 CASP12 BAD ATM APP CAD FADD PMC4935424__F4 Differentially expressed genes in BA, JA and UA groups mapped on the TNFR signaling pathway (1 denotes JA, 2 denotes UA, and 3 denotes BA) MAP4K2 TRADD HTRA2 FADD BAX PMC2996105__F7 Interaction of p75NTR and TrkB signaling BAD GRB2 PTEN BAX PMC8156939__F2 PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders TSC2 BAD TSC1 AGA IGF1 MYC MDM2 PTEN IRS1 PMC2964746__F4 Selected signal transduction pathways that affect AS of transcripts of genes important in cancer SRPK1 PMC3209384__F8 Schematic showing the mechanism(s) of activation of the NLRP3 inflammasome and NFKB signaling pathways by vMyxM013-KO virus infection in human monocytic cell line THP-1 NLRP3 TNF IL1B PMC6317881__F6 Interactions of genes involved in tumor progression and EMT FUT4 MMP17 CTSZ HEL-S-162eP CASP3 PDLIM2 TIMP1 BCL2 GJB2 ACP5 HEL113 ACAN CDH2 PCNA PMC9111413__F2 Non‐steroidal anti‐inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID‐19 IL5RA IL33 IL25 TSLP PMC10650444__F8 Compound 6b for promoting apoptosis of HepG2 cells MDM2 NSD2 BAX PMC4480161__F1 Cross-species comparison of PCD factors implicated in aging AIF1 HTRA2 FIS1 PMC9171412__F3 DNA damage initiates inflammatory signaling through DDR and cGAS‐STING. ATM‐NF‐kB pathway TBK1 NLRP3 CGAS TLR9 ATM IRAK1 IRAK2 TRAF6 IRF3 IRAK4 MYD88 PMC7599810__F1 Molecular pathogenesis of SARS-CoV-2 NLRP3 ACE2 PMC6442448__F13 Mechanism by which GBE attenuates diabetic atherosclerosis ATG12 ATF4 EIF2A MTOR TRAF2 XBP1 PMC8393346__F2 Risks and Function of Breast Cancer Susceptibility Alleles PALB2 BRIP1 RAD51D BARD1 NBN CHEK1 BRCA1 CHEK2 ATM BRCA2 RAD50 ATR RAD51C PMC8169786__F1 Recommendations for Vaccination in Children with Atopic Dermatitis Treated with Dupilumab: A Consensus Meeting, 2020 BCR STAT4 CD80 GATA3 PMC3255316__F1 Factors affecting the viability of dopamine neurons DRD3 CCDC62 CALB1 GDNF MCCC1 DRD2 BDNF PMC3615879__F4 Action of 20-HETE.Notes: Mitogens and ligands of G-protein-coupled receptors activate PLA2 and induce release of arachidonic acid, which is converted by CYP4A/F to 20-HETE EGFR GRB2 SRC PMC9181425__F4 Thirty Years’ History since the Discovery of Pax6: From Central Nervous System Development to Neurodevelopmental Disorders HES5 SOX2 LZTS1 REST DMRTA1 TBR1 CUX2 CDH2 DSCAM NEUROG2 CCND2 HES1 PMC3073350__F1 Linking actin dynamics and gene transcription to drive cellular motile functions RHO PMC9293526__F7 miR-26a-5p Suppresses Wnt/Beta-Catenin Signaling Pathway by Inhibiting DNMT3A-Mediated SFRP1 Methylation and Inhibits Cancer Stem Cell-Like Properties of NSCLC MYC SFRP1 PMC5852611__F1 Key players and stimuli in DRP1-mediated mitochondrial fission, both in physiologic and tumor conditions SUMO3 MFF INF2 CDC2 UCP2 SUMO1 SENP3 PMC4346874__F1 Apoptosis pathways in cancer HEL-S-62p BAD C9 TRADD TRAF5 APAF1 UNK TRAF2 FADD BAX PMC3863730__F6 Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC10336275__F3 CREB-induced immune response RELA TRAF6 IRAK4 MYD88 TNF PMC6885218__F1 MTOR signaling pathway is involved in liver IR injury and plays crucial roles in autophagy TSC2 RICTOR TFEB ATM NRBF2 ATG101 PTEN MTOR ATG14 PMC4219296__F1 Wnt signaling pathway NLK MMP7 APC GSK3B LRP5 CCND1 LRP6 RYK ROR2 BCL9 PMC2896868__F2 Toll-like receptors in kidney disease TBK1 CD14 TLR5 TLR9 IRF7 TRAF3 TRAF6 ATF3 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 RELA SIGIRR LBP TNFAIP3 TIRAP PMC3982103__F1 Astrocytic–Neuronal–Astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA PC CIT MAL PMC4742124__F1 Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma GRB2 STAT3 PMC11022384__F5 Therapeutic strategies targeting metabolism between GAMs and Gliomas SQLE HEL-S-90n DHCR7 ABCG1 ABCA1 ARG1 PMC8634714__F2 Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous TRADD IL33 IL25 TSLP TRAF2 PMC11022384__F3 Metabolic characteristics of microglia MTOR BDNF GLS PMC11022384__F4 Metabolic interactions between tumor cells and GAMs GPD2 HIF1A HEL-S-68p PMC8619244__F5 TRPV4 Mechanotransduction in Fibrosis TRPV4 NOX4 RHO RAC1 PMC7865618__F3 Mechanism leading to CRS and ICANS and potential role of IL-1 blockade VWF CD40 IFNG PMC7865618__F2 Different treatment strategies to modulate the IL-1–IL-1R pathway NLRP3 IL36A IL33 IL36B IL1B PMC8619244__F2 TRPV4 Mechanotransduction in Fibrosis FOS SMAD2 MAP3K7 SMAD4 JUN PMC8619244__F3 TRPV4 Mechanotransduction in Fibrosis TRPC6 TRPC3 TRPM7 PMC8269357__F6 Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer TH ESRRB CTCF MYC CDC2 ACHE RPS3 RBM22 SF3A1 STAT3 BAX PMC9962262__F3 Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures GSK3B RORB RORA MTOR PMC11786704__S1 Preparation and application of PC capsules for promoting wound healing in diabetic mice COX2 PC BAX PMC7911265__F4 Portion of the human metabolic chart (online diagram: ), shown at its highest zoom level with all labels drawn, and displaying a reaction tooltip CDA DPYD MCEE GDA UPP2 ADA TYMP PNP PMC6405412__F12 Role of AKR1C2 and AKR1C4 in male virilization CYP11A1 HSD3B2 AKR1C4 HSD17B3 AKR1C2 CYP17A1 STAR HSD17B6 PMC6367847__F2 NLRP3 inflammasome pathways and putative mechanism by which cyclic stretch negatively regulates IL-1B secretion in murine macrophages NLRP3 TLR4 IL1B PMC7487603__F1 Endothelial cell migration during sprouting angiogenesis VEGFA ROR2 FMNL3 CTNNA1 HEL114 RAC1 FOXO1 CDC42 PMC7882619__F2 Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise VCAM1 MTOR BAX PMC7697260__F3 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids, with distinct features present in PDF fibroblasts COL3A1 ID4 CSF3 CXCL8 PDF RIPK2 COX2 DCN COL6A1 NDUFS5 NDUFB6 NDUFS8 IL1A NDUFS6 ATP5G1 SLC25A5 LIF NDUFB2 CD44 IL6 COXFA4 LAMA4 ITGB1 ID1 ID3 PS1TP5BP1 NDUFC2 UQCR11 HEL-S-125m NFKBIA ND3 RELA NDUFB3 MME INHBA PMC5774508__F6 DEGs enriched KEGG map of the TNF signaling pathway in myocardial infarction IL15 TNF TRAF2 FADD SELE ITCH PMC7697260__F4 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids with distinct features present in PDF fibroblasts HEL-S-89n COL3A1 COL5A3 PDF ID1 DCN COL1A2 SEC61B COL6A1 SPCS2 INHBA SEC61A1 COL4A1 PMC2792482__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs TLR4 IRF3 TNF NOD2 TLR3 PMC3437946__F8 Synthesis and degradation of dopamine, norepinephrine, and serotonin TH TPH1 DBH MAOA PMC6019726__F1 Production of IL-32 and its downstream signaling network NOD1 IL1B NOD2 PMC5774508__F5 DEGs enriched KEGG map of the NFKB signaling pathway in myocardial infarction CD14 EGF NGF TRADD NFIB RELB LTB PARP1 CNTF LTA BCR ATM VCAM1 BASH LCK LYN LBP SYK LAT TIRAP PMC2673908__F2 Unifying model of Wnt signaling with regard to cardiomyogenesis WNT1 GSK3B LRP5 LRP6 ARHA PMC6627629__F6 Proposed mechanisms for fucoidan-mediated inhibition of osteoclastogenesis NFATC1 GSK3B PTEN PMC3580884__F3 Relationship between binding of ligands to the pattern recognition advance glycation end‐product receptor (RAGE), and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro‐ and microvasculature HMGB1 EGR1 NCL ARC PMC8476879__F3 Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases NLRP3 SOCS3 LPA MYD88 PMC3278439__F4 Analysis of the Fibroblast Growth Factor System Reveals Alterations in a Mouse Model of Spinal Muscular Atrophy FRS2 GRB2 ARHA CDC42 PMC4442787__F3 Of BK regulation, painful connections, and versatile neuropeptide signaling POMC NPY AgRP MC4R PMC4572416__F3 Pathways to AT2 cell injury/dysfunction defined by using mutant proSP-C isoforms as prototype substrates CD63 ATF4 EEA1 TRAF2 PMC9020799__F11 RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway NLRP3 TLR4 MYD88 TNF IL1B TIRAP PMC8058998__F1 Phosphorylation events in TLR signaling TBK1 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 BTK RIPK1 MAL PMC4591933__F1 Non-invasive imaging and quantification of EGFR kinase activation in vivo EGF CLC EGFR GRB2 CIC PMC3579325__F3 Selected pathways from enriched injured (EI) versus non-enriched (i.e., STD housed) injured (NI): demonstrating calcium signaling importance BCR DAO CAV2 PMC9499793__F15 Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves' Orbitopathy BCL2 MTOR BAX PMC3808153__F7 The 5S RNP Regulates p53 Homeostasis and Its Activation in Response to Nucleolar and p14ARF OverexpressionSchematic overview showing the central role of the 5S RNP in coupling the pathway of ribosome biogenesis to cellular proliferation RPL11 MDM2 RPL5 PMC8088111__F6 Signaling pathways involved in the effects of Mg2+ on CLS mediated by the GAAC pathway and Ecl1 family proteins F2 EIF2A PMC5647277__F1 Current view of the mechanisms responsible for activation and modulation of the reproductive axis in birds and mammals TSHB DBP EYA3 GNRH1 PMC5363674__F1 Scheme of the unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC3040753__F3 Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells HLA-DPA1 EGR1 CTSS CFB FOS CD74 C4A SERPINA3 HLA-DPB1 CFP HLA-DRB4 KLK6 B2M CP PMC10178209__F4 Biosynthetic pathway to produce patchoulol and Alpha- and Beta-santalol in S PTS IDI1 IPP PMC4818358__F1 Roles of interleukin-10 (IL-10) in determination of pregnancy VIT JAK1 STAT3 PMC5480029__F1 Sulfide (S2−) homeostasis and small-molecule chemistry that couples reactive sulfur species (RSS) and reactive nitrogen species (RNS) LIPA FES PMC7197376__F1 Manipulating a tumour suppressor HMGA2 SOX2 CDK2 CDK4 CDK6 PMC8616335__F5 Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer MCC ATM PMC2718491__F3 Multiple regulatory pathways for N-WASP and WAVE2 activation SHD SRA1 ABI2 ABI3 CDC42 PMC9180634__F1 Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide STAT1 GRB2 FGFR3 PGC CCND1 CNP SOX9 PMC3536698__F8 IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling TBK1 TLR7 RSAD2 IRAK1 CXCL10 TRAF6 IRF3 MYD88 TLR3 MAVS IFIT1 PMC4162362__F1 The sphingolipid signaling pathway SPHK1 SPNS2 SPHK2 PMC7343375__F2 Abbreviated diagrammatic representation of the PI3K, Akt, mTOR cell signaling pathway, and associated pathways, as a major regulator of cell function (see Laplante and Sabatini for a more extensive chart of mTOR-related cell signaling) TSC1 TFEB TBC1D7 PGC PTEN GRB10 DEPTOR RHEB PMC9406872__F1 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer HHIP SUFU PTCH1 GLI3 GSK3B SMO PMC5098276__F4 CCI-779 treatment induces expression change in mTOR signaling pathway components TSC2 RICTOR BRAF EIF4E HIF1A MTOR RHEB PMC8750192__F8 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis TRAF6 CCL2 MYD88 TNF TIRAP PMC9481585__F6 Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355 F8 PMC6478395__F3 BRAF mutations on tumor cell survival and the tumor microenvironment BRAF NRAS PTEN MTOR PMC3443855__F7 Nodal Signaling via an Autocrine Pathway Promotes Proliferation of Mouse Spermatogonial Stem/Progenitor Cells through Smad2/3 and Oct-4 Activation NODAL SMAD2 SMAD4 CCND1 PMC9406872__F2 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer HHIP PTCH1 PTEN MTOR PMC8750192__F1 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis TLR5 TLR9 IRAK1 CXCL8 TRAF6 CCL2 MYD88 TNF TLR1 TLR3 TLR7 TLR4 CD80 IL1B TIRAP MAL PMC9406872__F3 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer IHH SHH PMC3588864__F7 Possible mechanisms of estrogen/androgen action in the prevention of NAFLD/NASH F2 UCP2 HMGCR PMC6504231__F8 Functional interplay of IL-21 with type I interferons in the response to MRSA IL21R STAT3 PMC9321204__F4 Glycine betaine uptake and metabolism in marine microbial communities HEL-S-61p PMC9599896__F2 Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma EGFR GSK3B CDH2 AXIN2 MZF1 PMC11546914__F3 AI-Assisted Identification of Primary and Secondary Metabolomic Markers for Postoperative Delirium IL10 ITGAM LEP ATF4 CD40 SYK IL6 CCL2 AARS1 KARS1 CD68 IFNG PMC10507829__F4 Illustration of contributing factors of the signaling pathway for DDR1 in human adipose-derived MSC (A), (B), (C), which generated using ReactomeFIPlugIn in Cytoscape (B and C—enlarged parts of the image A) RUNX3 RUNX1 RUNX2 PMC10507829__F1 Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells EGF VASP BAD FLNA EGFR ARHGEF12 PAK4 TLN1 WAS PTEN ARHGAP35 PDPK1 PRKCA FYN VAV3 KDR HOXD10 PLCE1 SRC CCND1 EMP2 ACTN4 ARAF JUN CTSL RAPGEF1 HSPB2 DROSHA VEGFA CD44 ARHA DOCK1 RAC1 HRAS ITGB1 CRK SHC2 MAP2K1 ZYX GRB2 MYL12B BCL2 RAF1 PXN CAMK2A CDC42 AKT3 STAT3 PMC4431617__F1 Schema of the PI3K pathway TSC2 CCND1 PTEN MTOR PMC2063513__F6 Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling LAMB1 RECK MMP9 ITGB6 HCN2 EPHB4 PMC8348949__F2 Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? NTN1 SHH SMO PMC6668446__F6 GLI1 activation by non-classical pathway integrin AvB3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis SUFU SMO BMI1 PMC5831511__F3 Brain-immune interactions in perinatal hypoxic-ischemic brain injury IL10 IRAK1 SMAD2 TRAF6 PMC5038987__F6 Proposed mechanism of the priming phase of complement-induced liver regeneration CH25H SOCS3 HMGCR PMC5014907__F3 CD4+ T cell activation by antigen presenting cells and the IL-12/STAT4 pathway IRF8 APC CTLA4 IL12RB1 IFNG TNFRSF1A LCK STAT4 IL7R TYK2 CD80 TNFAIP3 SOCS1 PMC7674124__F1 Expression of PROK1 (A) and PROK2 (B) TBX20 HIF1A PROK2 PROK1 PMC8592567__F2 Candidate signaling cascades that mediate the action of Indigo and polysaccharides via the gut AIP AHR IRF3 PMC4925815__F1 Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation CD14 COX2 IL18 TLR4 IRF8 LBP IRF3 TLR1 PMC3615902__F3 Developmental data alters disease mechanism prediction EREG KIF23 SFN BIRC5 CDKN3 CENPF DKK1 HEL-S-104 CXCL13 NUF2 SERPINA1 MCM10 CDC2 KIF15 DIPLA1 MKI67 TPSAB1 DLGAP5 CENPA HSPA4 SELE LIF CENPE HCTP4 CGA AURKB CFTR ADCYAP1R1 CDC20 HMMR IGF1 CDC6 TWIST1 BUB1B CCNB2 NEK2 HEL164 CDT1 PLA2G2A INHBA PMC7752075__F2 Synthetic pathway of NO in ECs, inducers, inhibitors, the roles played and the effects of different components of the ECM CD47 SRC CD36 PMC8012816__F7 Model depicting that PER3 regulates stemness of PCSCs via WNT/Beta-catenin pathway PER3 PMC7824309__F3 Pathway enrichment analysis EGF PEMT PMC7162481__F4 Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer CD58 TWIST2 ALK KRT19 ALOX5 FLOT1 GRIN1 ZEB2 MDM2 MAPK1 RNF111 SKI SP1 RAD21 HOXB13 BHLHB2 RBM38 XPC FPR2 KRT18 CDKN1A BCL2 SCNN1A GAS2L3 RPS6KA2 CP SDCBP MAML3 HADHB KDELR2 DNMT3B STK39 NAF1 FOXA1 CCND1 IL2 CD40LG CDC2 NFATC1 NR3C1 EMSY TCF2 BCL2L2 ADRA1B EVI1 LYN IL6ST JAK1 GPR65 PMC3581534__F7 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor LIPC APOO MYCBP STAMBPL1 APOD CRAT NEFH CSF2RB MAPRE3 RGS13 ARL4C RBM28 NPL HESX1 CYFIP1 PHB2 PHF3 CXCL11 KRT14 YIPF6 SLC25A2 CDON AREG ERBB3 NPPB UGDH TCN2 TNLG2B MPZL1 SDK2 SLC26A3 PMC8020202__F2 Roles and mechanisms of CBS/H2S and CSE/H2S system in breast cancer INS SIRT1 STAT3 PMC3581534__F5 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View XK PCYT1B HEL-S-99n PPY CYP2C18 F3 LILRB4 RPS27 PSMC1 PRR3 ELAVL2 CLPP MCM9 PPIE Nbla10236 CFB LGI1 FES OPN1SW MCM7 ASPA SNRPB KPNA2 TXNIP PPIB HEL107 HHEX PMC8336719__F1 Roadmap for AHR targeting in skin inflammation KYNU AHRR AHR OVOL1 PMC6901966__F10 Protective effects of farrerol on CDDP-induced AKI and the underlying mechanism NLRP3 KEAP1 NOX4 BAX PMC4277277__F2 Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats SQLE PMVK MVD IDI2 DHCR7 FDPS EBP MVK HMGCS1 HMGCR PMC6362265__F1 Three branches of the unfolded protein response (UPR) ELF2 ATF4 EIF2A TRAF2 PMC9131376__F4 Recent Progress in the Development of Novel Mycobacterium Cell Wall Inhibitor to Combat Drug-Resistant Tuberculosis INHA PMC5725016__F10 Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3) GALNS DKK3 PMC4481438__F1 Effect of ileal bile acid transporter in the proximal ileum CYP27A1 CYP8B1 CYP7B1 PMC6868851__F3 Mechanism of miR21 in PC development BAD PTEN MTOR PMC3663255__F1 Notch signaling pathway HES5 NUMB RBPJ FURIN HES1 PMC9529349__F1 Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome TH NLRP3 MYD88 GSDMD PMC11661909__F4 Metastatic brain metastasis MUC1 ENPP1 HLA-G PDGFRA EGFR CD44 RAC1 PMS2 MMP3 RET DOCK4 CXCR4 MSLN LASS1 JUN STAT3 BRD4 PMC11685086__F1 FSH functions through the FSHR UCP1 VCAM1 LDLR FSHR HMGCR PMC6354556__F1 Role of the biomarkers explored in the study on EGFR signaling MOG HGF YAP1 HEL-S-28 EGFR GSK3B SRC CDCP1 AXL PXN STAT3 PMC9343460__F8 Effect of PINK1 on Alzheimer’s disease-like pathology induced by intracerebroventricular injection of forskolin in rats MAF KEAP1 GSK3B NQO1 PMC11685086__F2 Action of FSH-FSHR in OC proliferation and EMT CCND1 SPHK1 FSHR PTEN CDH2 SPHK2 PMC11685086__F3 Nanotechnology and immunotherapy for ovarian cancer (OC) targeting FSHR FSHB CD8A HK2 PMC4194125__F8 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer SLC7A5 HEL-S-26 SLC2A12 FH DLD HIF1A DLAT SLC38A1 SDHA PMC6397348__F9 Diagram: BPI fold-containing group A member 1 (Bpifa1) regulation of noncanonical Toll-like receptor 4 (TLR4) and interferon (IFN) signaling STAT1 TLR4 BPIFA1 STAT2 IRF7 IRF9 CXCL10 STAT4 IRF3 MYD88 IL12RB1 IFNG PMC5192300__F2 The cellular trafficking of CD1 molecules CD1D CD1A CD1C PMC4107957__F1 Toll-like receptors and TLR-mediated signaling pathway TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC5746140__F3 Implication from RAS/RAF/ERK signaling pathway increased activation in epirubicin treated triple negative breast cancer CS POR MTOR PMC9291299__F4 Translation initiation and its relevance in colorectal cancer ELF5 ELF1 SUI1 EGFR APC GSK3B LRP5 LRP6 PTEN EIF4E RHEB EIF5 TSC2 TSC1 ELF3 ATF4 EIF2A GRB2 EIF4B ABRA PMC8935981__F10 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches NR3A2 FANCD2 ATM BRCA2 RAD50 XPC RAD51 MSH2 ATR BRCA1 PCNA PMC6034042__F4 Nicotinamide Adenine Dinucleotide (NAD+) synthesis pathways NAPRT NAMPT PMC6768428__F1 The STING signaling pathway TBK1 CGAS DDX41 IRF3 ZBP1 PMC2148066__F6 GenMAPP pathway showing changes in expression of the transcription factor PPARA and fatty-acid degrading enzymes upon fasting HADHB CRAT ACADSB CPT2 NR1C1 ACADL ACADS CPT1A ACADVL LPL PECR GPD2 ECHS1 EHHADH ACADM PMC8759737__F1 SHP2-associated Noonan syndrome in RASopathy CSH2 GRB2 PMC10573607__F4 Soluble sugar, cellulose, and lignin contents IRX1 CAD JUN PMC7899014__F10 Cell signal transduction pathways of 7 central hub genes in CMs infected with SARS-CoV-2 CCR2 PLG IRF7 FOS CXCL8 TRAF6 IL1R1 IRF3 IFNB1 CCL2 MYD88 MAP2K3 STAT1 FYN TLR4 ACE2 JUN PMC11215092__F1 Molecular pathways and targeted therapies in head and neck cancers pathogenesis WWC3 EGFR LRP5 MYC LRP6 PTEN LATS1 MTOR FBXW7 CREBBP EP300 AXIN1 GRB2 AXIN2 JUN STAT3 PMC3568707__F1 BiP as master regulator of the Unfolded Protein Response ATF4 EIF2A XBP1 PMC1999497__F2 Flow diagram of the P53/apoptosis pathway APAF1 BCL2 BAX PMC8663982__F4 Cytokine signaling inhibition on inflammation-driven tissue remodeling STAT1 STAT3 PMC8663982__F5 Cytokine signaling inhibition on inflammation-driven tissue remodeling SMAD2 SMAD6 SMAD4 BMP7 MTOR MAP3K7IP1 PMC2680287__F1 Unraveling the complexities of the interferon response during SARS-CoV infection IFIT3 IFIT2 CD48 CD83 CCL5 IFNGR2 CCL2 CR1 MX2 MX1 IFNG IRF6 OASL STAT1 OAS1 OAS2 OAS3 IFNA13 CD84 IFNGR1 IL1B IRF2 IFI16 STAT2 IRF7 IRF9 IRF3 IFNB1 IL6 TNF TLR1 IFNAR1 TLR3 CD69 IFI44 NFKBIA NFKBIB CARD9 NFKB2 NFKB1 ISG20 TYK2 JAK1 IFIH1 PYCARD NFKBIE IFIT1 PMC7293224__F7 Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway ATG3 MTOR PMC10559873__F6 Detail of pathways TH KL COX2 FRK LCN2 S100A9 TNF PAH FADD SELE PMC5986469__F7 Illustration of the Compound-Group-Target-Pathway (CGTP) network ALB NR3C2 HEL-S-69p HEL111 NR1i1 FDPS F2 CDK2 SRC IL2 RBP4 ELANE MME PMC9180951__F5 Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals SLC4A1 SLC26A3 HVCN1 PMC7573281__F4 Signaling pathways over-represented by genetic variants and differentially expressed genes Over-represented pathways and related genes are plotted SYN2 POLG PLCG2 RAC1 SNAP25 LIG1 FEN1 ARHG ITSN2 CADM1 POLE KALRN APEX1 FARP1 THBS1 COL9A3 OGG1 PCNA GP6 PMC5986469__F8 The interaction effects of enriched KEGG pathway terms and putative target proteins identified in the present study PLG EGFR MAPK10 ALB TNF HRAS MMP3 HEL111 C9 FGFR1 MAP2K1 F2 CDK2 APP SRC IL2 MAPK11 APOE CD68 PMC7849831__F2 Mitochondrial dysfunction in astrocytes contributes to neuroinflammatory activation of astrocytes NLRP3 PINK1 CGAS PMC5273810__F4 IFN-gamma signaling pathway CRK IFNG PMC5273810__F6 Network analysis using key molecules in VL pathogenesis FGF4 PLCB3 HGF TRADD RUNX2 EGFR GSK3B MYC CREB1 TRAF6 PTEN HIF1A E2F3 FGFR2 FGF9 IFNG STAT1 CBX2 E2F2 FRS2 PTPN6 SP1 IRF-1 JUN ADAM9 SOX2 IL13RA2 HEL-S-28 IRF8 LIF HRAS IRS1 SUZ12 MAP2K1 IGF1 CDK2 LYN ZAP70 GRB2 SYK JAK1 TRAF2 FADD SOCS1 BRD4 STAT3 PMC9709153__F6 Molecular mechanisms of exercise contributing to tissue regeneration ATF7 PCDHJ TIMP3 SOST CCND1 BCL2 PTEN HIPK1 MTOR SIRT1 PMC11312265__F1 Molecular mechanisms of inhibited and activated canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC11312265__F2 Signaling cascade of non-canonical Wnt/PCP and Wnt/Ca2+ pathway NLK DAAM1 PTK7 RYK ROR2 RHO RAC1 ROR1 CDC42 PMC9709153__F4 Molecular mechanisms of exercise contributing to tissue regeneration ERBB2 CCND1 CDK4 NRG1 POLI PMC9709153__F2 Molecular mechanisms of exercise contributing to tissue regeneration PIEZO1 SOST LRP5 LRP6 HDAC5 PMC11312265__F5 Non-canonical Wnt/PCP and Wnt Ca2+ signaling and their implications in cancer NLK CASR CD44 RHO VANGL1 PMC9709153__F3 Molecular mechanisms of exercise contributing to tissue regeneration CITED4 IGF1R IGF1 NRG1 MTOR BDNF PMC9174462__F1 Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target NLRP3 AIM2 IL1B GSDMB GSDMD BAX DFNA5 PMC11802527__F2 Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure NLRP3 RIPK1 SCIMP LYN APOC3 SYK IL1R1 GSDMD PMC9602726__F5 GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway TUBA4A CDS2 EEF1A1 TFDP1 TSG101 AK2 POLE4 GPN3 HEL-S-2 MEN1 PID1 B2M SP1 CEP290 IWS1 RHOBTB3 CNOT8 CDKN1B NCOA6 NME7 PUM2 GJA1 ENO2 PIK3CA POLR2C KAT6A EPHA2 PI4KB PMC4855686__F2 CAMs can activate neurite outgrowth through different mechanisms TAF1 L1CAM APC PCDH7 RAC1 CELSR3 CELSR2 CDC42 PMC2848237__F2 Reconstruction of a KEGG pathway CDC20 CDC6 CLN3 PMC1952230__F1 Regulation of CXCR4 Signaling SRC RHO CDC42 PMC4972100__F1 The serine synthesis pathway and downstream anabolic reactions of serine PSAT1 PSPH PHGDH PMC10982391__F1 Direct immunomodulatory function of TDEs on CD8+ T cells HLA-G OGT BMI1 ARG1 PMC10982391__F2 TDEs indirectly regulate CD8+ T cells via the TME cells PIGF LGALS9 MMP9 ARG1 PMC9598036__F4 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics BACE1 NRG1 MTOR ITGB1 HES5 CSF1R FYN NOTCH1 ABCA1 BDNF ARG1 LINGO1 APOE PMC7583029__F1 Plant abiotic stress perception and response, concerning different cell compartments/organelles, and the terpenoid biosynthesis pathway MOS MVD HEL-S-11 IPP MVP PMC9406972__F2 Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion APC CD80 CTLA4 IL10RA IFNG IL10RB PMC4673119__F1 Regulation of T follicular helper cells by ICOS SELPLG TBX21 CCR7 S1PR1 FOXO1 ICOS SELL PMC6167501__F1 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy NF1 FOS MYC GRB2 PYY JUN PMC2939308__F1 Activation of PPARG and PTEN Cascade Participates in Lovastatin-mediated Accelerated Differentiation of Oligodendrocyte Progenitor Cells HEL-S-62p MBP NTS CDK4 PTEN SOX10 SP1 PMC4035704__F3 Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP TSC2 TSC1 FOXO1 RHEB PMC6167501__F7 TGFB signaling pathway in melanoma ARHA TGFB1 PMC6167501__F8 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy NOTCH2 NOTCH4 DLL4 JAG2 NOTCH1 FURIN DLL3 NOTCH3 PMC6167501__F2 PI3K-Akt pathway activity BAD MDM2 PTEN MTOR FOXO1 PDPK1 PMC6167501__F4 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy APC GSK3B BCL9 CP PMC5567140__F4 NCL expression affects cholesterol synthesis ME1 NCL IDI2 ACACA EBP SC5D DHCR24 IDI1 HMGCS1 ELOVL6 HSD17B7 GGPS1 CYP51A1 HMGCR PMVK MVD SCD DHCR7 FDPS FADS1 MSMO1 PMC6167501__F5 Canonical and non-canonical NFKB signaling pathways TRAF5 RELB CD40 REL TRAF2 LTBR PMC9036418__F1 3q26 CNG activates PKCι-driven oncogenic signaling pathways in LUSC PAK1 SOX2 ECT2 RAC1 PMC11393980__F8 Other targets of pVHL in ccRCC and SNC hemangioblastomas TBK1 ZHX2 SPHK1 SFMBT1 PMC5923293__F6 Ingenuity pathway analysis (IPA) of miR-152-3p-target interactions in prostate cancer signalling LEF1 RB1 PMC10831402__F2 Suggested PML/RARA-related signaling pathway that leads to cell proliferation and the evasion of apoptosis RARA PML JUP CDK2 CDKN1B PMC7392626__F1 cGAS-STING pathway in oncogenesis and cancer therapeutics TBK1 CGAS ENPP1 TANK TRAF3 IRF3 TRAF2 PMC7392626__F2 cGAS-STING pathway in oncogenesis and cancer therapeutics CGAS RAE1 IRF3 IL6 CD80 CXCL11 PMC9598036__F3 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics HES5 FYN RTN3 LPL ADAM10 MTOR ARG1 LINGO1 APOE PMC3253886__F4 IRF signaling pathway that was generated from pathway analysis of proteins with significant fold changes across both studies IL10 IFNA4 IRF3 TLR3 MAVS PMC8663982__F2 Cytokine signaling inhibition on inflammation-driven tissue remodeling NLRP3 TLR4 IRAK1 TRAF6 MAP3K7IP1 PMC10135928__F7 Lipid synthesis in adipocyte differentiation and functions DGAT1 DGAT2 EBP MSC TG FASN CD36 PMC5338429__F7 Model of Gata4 transcriptional regulation in atrial septation CDK4 PTEN GATA4 PMC8663982__F3 Cytokine signaling inhibition on inflammation-driven tissue remodeling TLR4 TRADD MTOR SMURF1 PMC7075706__F4 Intracellular pathways involved in proinflammatory effects of soluble uric acid NLRP3 IL1A CARD8 IL6 MTOR IL1B PMC3774987__F3 Essential TLR-associated signaling pathways and cytokine production TLR5 TLR4 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 TLR10 TLR3 TIRAP PMC6225629__F4 Reconstructed metabolic pathways (KEGG) of S RPIA LPA HEL107 RPE HEL-S-5 HEL-S-162eP PMC5372268__F4 KEGG pathway hsa05200 “Pathways in cancer” RARA KMO CRKL PMC4965259__F1 Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors GRB2 PTEN MTOR PMC7759681__F3 Function enrichment analysis of survival-related DEGs in STAD PDE1B SOX17 RBP7 TFDP1 MTBP TTF2 ANKRD1 LMNB2 ZFP36 POLE CCL14 GHR RNASE2 KIF15 MSH2 KLHL17 TCF3 KIF24 NAA40 SAMD12 SLC12A7 DNAAF3 FBXL7 RGS2 MMRN1 MICU3 TMEM63A UHRF1 DBF4B TMEM201 CCNO NAA25 P2RY14 CCDC15 CLSPN MCM2 CD36 ENTPD6 COPZ2 LFNG CASP2 CIT HEL-S-104 HEL-S-70p SPATA13 MASTL KIT NMB INCENP TACC3 DTX4 RCC2 RMI1 AGO2 CDO1 TFF2 CCL15 TFF1 EFNA4 PFKFB2 SFMBT1 WDR62 PMC1993849__F7 Ischemic/hypoxic effects on cardiac myocytes and stem cells MSC TNF STAT3 PMC3912696__F1 Role of cytokines in Th1 and Th2 differentiation of lymphocytes IL10 CCL24 CXCL10 CCL17 CXCL9 TNF CCL22 IFNG PMC10903931__F1 Hepatic phospholipid biosynthesis pathways TG PSD PEMT PMC5134418__F2 Depiction of prasugrel metabolic pathway CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC6755131__F7 Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway FPR2 PLCG2 PMC10903931__F4 Apoptosis model induced by fatty acid metabolism PC TG BAX PMC10903931__F5 LXR-LPCAT3-ERS signaling pathway LPCAT3 ATF4 EIF2A TNF TRAF2 XBP1 PMC8785421__F1 Signaling pathway and polymorphisms of Mrgprs KCNQ2 TRPC3 TRPA1 ORAI1 TRPV1 PMC7047232__F6 Cartoon presentation of proposed cellular and molecular mechanisms for the synergistic effects of ATO/AA combination treatment CASP9 BCL2 IL1B PMC6002396__F8 Model depicts the multiple mechanisms by which NXT inhibits the development of diabetic nephropathy in db/db mice MMP2 SMAD2 TGFBR2 VEGFA GCK TGFB1 INSR PMC8615685__F3 Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson’s Disease NLRP3 TLR4 C4A IL1B PMC1853294__F10 Cell injury to wound closure, including P2Y activation, intracellular Ca2+ release and EGFR signaling ERBB2 EGFR SRC PMC3321306__F1 Gene expression network of the heritable transcripts in the nuclear factor kappa B signaling pathway HMGB1 AHR NPM1 TRADD PMC10607207__F1 Neuroprotective intracellular signaling pathways in the central nervous system involving TRPC6 activation TRPC6 BDNF STIM2 PMC8350724__F1 Pyroptosis, a New Breakthrough in Cancer Treatment NLRP3 IL18 NLRC4 NLRP1 AIM2 IL1B GSDMD PMC3955095__F2 Targeting the Bcl-2 Family for Cancer Therapy BAD DIABLO BAX PMC8350724__F2 Pyroptosis, a New Breakthrough in Cancer Treatment NLRP3 IL1B GSDMD PMC3937760__F4 miR-182 plays an important role in CEBPA/miR-122/IGF1R pathway IGF1R GSK3B CCND1 CEBPA PMC4355251__F2 PRR and signaling pathways that lead to differentiation of antifungal T-helper cells TH TLR9 MYD88 TNF TLR1 TLR3 NLRP3 IL16 TLR7 TLR4 BCL10 SYK REL MAL PMC3887856__F1 Two branches of pathway upstream of mTORC1 SLC7A5 TSC2 TSC1 IGF1 SH3BP4 MAP4K3 PTEN SLC3A2 DEPTOR IRS1 RHEB PMC9085237__F16 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties TIGAR TSC2 TSC1 RHEB HK2 PMC5436143__F6 Gain of function Beta-catenin in the uterine mesenchyme leads to impaired implantation and decidualization IHH PGR WNT4 BMP2 PTCH1 LIF PMC3887856__F3 SH3BP4 is a potential tumor suppressor functioning in the amino acid-mTORC1 pathway TSC2 TSC1 IGF1 SH3BP4 PTEN RHEB PMC4961512__F8 Curcumin and PKC signaling pathway in colon cancer EGR1 EGFR UGT1A1 PMC6690952__F7 Schematic diagram depicting the mechanism by which suppressor of cytokine signaling 5 promotes or inhibits hepatocellular carcinoma cell metastasis via phosphoinositide-3 kinase/Akt/mammalian target of rapamycin pathway-mediated autophagy MTOR SOCS5 PMC10193376__F4 Protein network encoded by jointly regulated genes BCL7A EGFR VPS18 PTEN S100A1 CCDC6 CDC40 TP53INP1 MYO6 CFH E2F2 KLF13 RNF123 MMP25 MAP3K10 MMP16 ZNF652 ZNF117 ZNF28 ZNF254 ZNF493 TBC1D14 ZNF561 ZNF611 ZNF431 MYLK VPS51 COL10A1 PMC5346713__F8 Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women WNT3A BMP2 MAD2L1 SMAD2 PURA MYC DROSHA SERPINB5 PNPT1 PMC5037849__F2 Dock3 signalling pathways in optic nerve regeneration ARHG APC GSK3B DOCK3 RAC1 PMC5746010__F1 Interactions of ALS/FTD associated genes with autophagy pathway TBK1 VAPB ULK1 RAB8A NRBF2 ATG101 OPTN YOD1 RAB1A WDR41 SMCR8 C9orf72 VCP ATG14 PMC446107__F1 TLR signaling pathways TLR8 TLR7 TLR4 TLR9 IRF3 MYD88 TLR1 TLR3 TIRAP MAL PMC4116751__F1 Model Genetic Pathways EGF KSR1 EGFR GRB2 MED23 PMC5803300__F8 ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway ANKRD11 BDNF PMC7910861__F1 Evasion of RLR-mediated innate immunity through viral manipulation of ubiquitination and ISGylation TBK1 ISG15 USP15 USP27X IRF7 CYLD IRF3 TRIM25 MAVS PMC10420321__F8 Molecular mechanism underlying the beneficial effects of FJE in the OVA-induced CARAS mouse model IL33 TSLP PMC5790772__F1 Heparan sulfate proteoglycan (HSPG) protein family organization and HS biosynthesis EXT1 PMC3775637__F3 Targeting the PI3K and BTK pathways in NHL TSC2 BTK TSC1 MYC MDM2 SYK PTEN RHEB PMC5363240__F5 Proposed role of RUNDC3B in the MAPK signalling pathway MOS MAX RUNDC3B MYC SMAD4 CRAT PMC3398478__F1 MAPK Pathways in S SOST TF CDC42 PMC5091087__F5 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HIPPOCAMPUS PROTEOME AND METABOLOME PROFILES IN ADULT OFFSPRING CCT6A HEL-S-30 NAPB ENO1 ENO2 ECHS1 PGAM1 MDH2 HEL-S-68p PMC4511315__F1 Schematic diagram for signaling regulation of acetylcholinesterase (AChE) EGF FGF2 ACHE PMC5319910__F4 Histone chaperone networks shaping chromatin function MCM2 HIRA NASP TLK1 IPO9 TLK2 TONSL HAT1 PMC8687848__F8 Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy GFAP TNF GLP1R PMC3821554__F1 The TGFB signaling pathway is regulated at multiple points by ubiquitin-mediated targeting and proteasomal degradation SMAD4 PMC7347075__F1 Metabolic kynurenine (Kyn) conversion pathway IDO1 HEL-S-90n KYNU KMO PMC4723075__F10 Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte IRAK1 TRAF6 JUND IL1R1 JUNB PMC3754784__F1 Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC4197719__F1 Mechanism of canonical HH signal transduction in vertebrates GLI3 GSK3B SHH SMO PMC9022290__F2 CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate ACSL1 CPT2 HEL-S-104 CD36 PMC8615614__F1 Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma TSC2 TSC1 GSK3B MDM2 GSK3A PTEN RHEB PMC9669749__F2 Inflammatory pathophysiological mechanisms implicated in postpartum depression NLRP3 IL6 FOXP3 PMC3312677__F8 Genetic pathways involved in the regulation of the Mesp2 pathway RIPPLY2 MAML1 TBX6 LFNG MESP2 EPHA4 PMC4364943__F10 Proposed model for the integration of NFAT and NFKB signalling pathwaysSwollen AF conidia are taken up by macrophages BTK TLR9 SYK MYD88 PMC4937511__F10 Three pathways identified as altered based on the 12 SCI biomarker candidate proteins as input GOT2 ALB HEL-S-99n HEL-S-87p NR1C1 ELL FASN PMC3491811__F3 Calcium regulation of keratinocyte differentiation FYN SRC RHO PMC4283519__F1 Signaling pathway interaction and effects of modulators: cGMP and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelet aggregation in patients with metabolic disorders IL1A COX1 GC VWF PMC4306233__F2 Roles of F-box proteins in cancer FBXO5 MYC MCL1 DEPTOR JUN FBXW7 SKP2 PMC5082387__F2 TAM-dependent immunity IL10 STAT2 APC IFNE ARHA PMC5173117__F3 Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer SRM SMS PMC6830349__F2 Cell structure and function SCAI ADRM1 CDK5 CLN3 UFD1L YOD1 PMC3494767__F5 Synergistic cancer cell death in response to stress when TSC2, but not Pten is inactivated in the context of a deregulated Rb pathway TSC2 TSC1 CCND1 PTEN PMC8246597__F11 AMBRA1 regulates cyclin D protein stability and signalling through the RB pathway CUL4B AMBRA1 CDK4 RBX1 DDB1 CDK6 PMC7695248__F6 Sex-dependent metabolic and transcriptional changes after disrupted Cyp51 from cholesterol synthesis align with hepatocarcinogenesis in humans GYS2 GHR SF1 GCK CYP7B1 TG NR1C1 CYP7A1 CD36 HEL-S-22 PMC5436606__F1 PD-1 and CTLA4: Two checkpoints, one pathway? APC LCK PMC6830349__F3 Diagram that illustrates the in situ flow of downregulated proteins (mark in green) in early development as a consequence of cAMP stimulation PITRM1 AOAH LACTB SCD GRWD1 GTPBP4 PISD ACLY GATB PMC8758946__F1 Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation RET LMX1A MSX1 LHX3 TBR1 PMC8037903__F1 Role of gut in inducing adipose tissue inflammation CD14 TLR4 LBP PMC6927425__F4 Targeting Wnt signaling to combat cancer APC PMC11617596__F3 NAT10 plays a critical role in cancer FOXM1 ANKZF1 NAT10 TFAP2A AHNAK AXL MAST1 NOTCH3 YTHDC1 CEBPB PMC11617596__F4 Ac4C‐related signaling pathway in cancer CCND1 NAT10 CDH2 PMC6927425__F2 Non canonical Wnt signaling ARHA ROR2 CDC42 PMC7730553__F8 When LPS binds to TLR4 in the cell membrane, the resulting complex can lead to the activation of adaptor proteins including MyD88 and TIR-domain-containing adapter-inducing interferonB (TRIF) COX2 IL16 TLR4 MYD88 TIRAP PMC12086256__F5 Interactions of vascular endothelial growth factor receptors (VEGFR) with co-receptors and structural features of Neuropilin FGFR1 FGF2 EGFR CD44 NRP2 EPHA4 PMC12086256__F6 Signal transduction of vascular endothelial growth factor receptors FYN GRB2 SRC SHB CRK PMC12086256__F7 Negative regulation and fine-tuning of VEGFR2-mediated signaling pathways PLCG1 VEGFA SRC PMC12086256__F8 VEGF/VEGFR signaling controls angiogenesis and vascular permeability PC SRC PMC12086256__F9 VEGF/VEGFR signaling under pathological conditions PIGF VEGFC MMP9 VEGFA SRC VEGFB PMC3472969__F1 Genotypic-phenotypic model of estrogen metabolism and exposure (yellow box represents genotype component with phenotypic factors outside) CYP1B1 H1-2 CYP1A1 PMC11576426__F5 KEGG pathway “Regulation of actin cytoskeleton” (ssc04810) F2R F2 APC CXCR4 INS FGF19 ABI2 RHO HEL114 LPA FGD1 PXN PMC8920679__F3 Cellulosic Ethanol Production Using a Dual Functional Novel Yeast PDC PGM3 PGM2 ACO2 ENO2 ADH7 HEL-S-4 PMC3281071__F4 RNA-seq Reveals Novel Transcriptome of Genes and Their Isoforms in Human Pulmonary Microvascular Endothelial Cells Treated with Thrombin EGF TBP EGFR RHO SOS1 CP PMC9606402__F5 Gadd45b in neurologic and neuropsychiatric disorders: An overview GADD45B GAP43 MTOR BDNF BAX PMC85642__F8 Schematic model of cyclin E-associated kinase activity as an integrative convergence point for the regulation of G1/S transition by the “classic” pRb/E2F and the “parallel” Myc-dependent pathways in mammalian cells (thick arrows) CDK2 MYC PMC11201617__F1 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview EGF HGF EGFR PMC11201617__F2 Canonical activation of the WNT/Beta-catenin pathway PIG59 APC TBX3 GSK3B GPR49 SP5 PMC11201617__F3 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview MMP2 BIRC5 MMP9 SNAI2 BCL2L1 PMC11201617__F4 Hippo signaling pathway NF2 LATS1 LATS2 PMC11201617__F6 Notch signaling pathway DNER DLK2 CCND1 EGFL7 SOX9 HES1 PMC9533616__F5 lncRNA PVT1: a novel oncogene in multiple cancers AGO1 SERPINI1 FGFR1 NR1i1 ARL2 FOXM1 FGF2 TRPS1 STAT3 PMC9533616__F6 lncRNA PVT1: a novel oncogene in multiple cancers VEGFC KIF23 BCLAF1 TWIST1 ZEB2 BMI1 CDC2 PMC9533616__F8 lncRNA PVT1: a novel oncogene in multiple cancers IGF1R SOX2 REN ERG PTBP1 TMBIM6 TCF2 GREM1 TSHR BCL2 ELF4 MEF2C HK2 PMC2390552__F6 Analysis of Nodal signaling processes in ERK1MO and ERK2MO gene expression profiles BAMBI EGF UBE2D1 NODAL SMAD2 SMAD4 SOX17 ACVR2B NFKB1 FOXG1 SMAD1 JUN FOXH1 PMC2390552__F7 Analysis of FGF signaling processes in ERK1MO and ERK2MO gene expression profiles MAPKAPK2 BAD NODAL SOST NRAS CREB1 SOX17 FRS2 GRB2 SHCBP1 ARAF SP3 SP9 PMC2390552__F8 Analysis of Wnt signaling processes in ERK1MO and ERK2MO gene expression profiles NLK RAC3 APC GSC SOX17 CDX4 GATA2 PMC2390552__F9 Analysis of BMP signaling processes in ERK1MO and ERK2MO gene expression profiles BAMBI FST NOG BMPR2 ACVR2B BMPER SNAI2 PCCA GNB1 ID3 PMC7283470__F1 Emerging role of PTEN loss in evasion of the immune response to tumours CXCL1 IRF3 PTEN MTOR PMC7028706__F9 Protein–protein interaction network generated for shared miRNA target genes after miRNET analysis MAFK ADA TNF ADRBK1 ADAM17 IFNG PMC5102796__F8 Model showing the relationship between HPV-induced replication stress, activation of the ATR/Chk1/E2F1 signaling pathway, RRM2 accumulation and productive viral replication RRM2 ATR PMC9533616__F3 lncRNA PVT1: a novel oncogene in multiple cancers PYGO2 ULK1 SEMA4D ANGPTL4 ATG3 YAP1 INCENP SHH HIF1A VMP1 HK2 PMC9533616__F4 lncRNA PVT1: a novel oncogene in multiple cancers COX2 RUNX2 YBX1 EGFR VEGFA MAPK1 IRS1 FJX1 BAX PMC4985245__F1 IL-33 signaling pathway IRAK2 IL33 TRAF6 IRAK4 MYD88 IRAK3 PMC6895267__F9 The proposed working model NAT10 PARP1 MORC2 CHFR PMC8150590__F1 Crosstalk between Interleukin-1B and Type I Interferons Signaling in Autoinflammatory Diseases NLRP3 CGAS IL1B PMC7250673__F1 Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis SEMA4D SEMA3A SLIT3 CTHRC1 PMC1774081__F6 Math1 signalling pathway CCK GIP RAC1 HES1 PMC15871__F3 PI3′K signaling modules in mammals and nematodes have implications for cancer PTEN PMC3070611__F3 One experimental result of identified pathways from ovarian expression data CEBPD GRB2 PMC6458848__F3 DEGs clustered in the PPAR signaling pathway UCP1 HEL-S-28 LPL PMC4337546__F7 Schematic diagram showing the cross talk between HCV and miR-373 inhibiting IFN signaling STAT1 STAT2 TYK2 JAK1 PMC3576710__F1 Transmembrane protein UNC93B1 (black spring-like shape) associates with various toll-like receptors (horseshoe-like shapes) in the endoplasmic reticulum to help load them into vesicles coated with COPII for transport to the Golgi TLR7 TLR9 TLR3 PMC7537965__F1 Workflow for drug and vaccine repurposing ANKRD65 PTMS CCL3L3 EIF4EBP1 IFNG CCL24 F3 SF1 IL4 CSF2 PHF20 FPRL2 IL1A LYZ HDAC10 TBX2 AIF1 RAB31 IL24 ADRB2 IL6 TNF GLRX PRPF6 KSR2 BIRC2 LYN PRMT6 CCL20 HEL-S-51e FCN1 VMO1 RNASE6 TGFBI CCL3 GPR162 PMC7307829__F5 Analysis of TLK1 interactome and hypothetical pathway UBC FYN PLK1 CDK2 CCNB1 TLK1 CCND1 CDC2 PXN AURKA CDC42 PMC3070611__F4 One of experimental result from pathways intersection CEBPD HES5 PI3 RHO PTEN ZRANB3 HES1 PMC3070611__F5 The shortest pathway identified by our system CEBPD HEL-S-44 CEBPG PMC7537965__F4 A venn diagram showing overlaps between BCG genetic mimics and key hubs with SARS-CoV-2 and Corona viruses interactomes GGH NEU1 F2RL1 CCL5 BCL2L1 ATF5 CIT HMOX1 IFNG RIPK1 NDUFA5 HEL-S-277 PLAT PABPC1 RYBP SIRT5 EIF4B SCARB1 PSEN2 PPIG NDUFS3 IL25 HEL-S-69p CAMLG CSNK2B GNB1 IGF2R BRD4 PMC5902028__F2 TIGIT pathway FYN APC LCK GRB2 CD96 TIGIT CD226 PMC3244904__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT PC PGP INS PSD HEL-S-5 PMC10874582__F2 Immune-related signalling pathways in mosquitos AGO2 DICER1 DROSHA MYD88 PMC12234771__F4 Comprehensive strain‐identification pathway for the seven UCYN‐A strains, established by the codon aversion motifs of the 40 genes RPIA ARC NR1A2 RPE PMC8583315__F1 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? ZNRF3 RNF43 APC GSK3B LRP5 LRP6 PORCN GPR49 ROR1 PMC8165552__F1 Mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis HEL-S-62p SQOR GOT2 ETHE1 HEL-S-32 MDH2 PMC8583315__F3 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? ZNRF3 RNF43 DKK3 APC GSK3B LRP5 LRP6 PORCN GPR49 BCL9 ROR1 PMC6411635__F2 Metabolic reprogramming of T cells after allogeneic stem cell transplantation HK3 MTOR HK2 PMC7492732__F1 Biosynthesis of kinamycin ALPL AIP ALPI PMC2932677__F1 Diversity and Plasticity of Th Cell Types Predicted from Regulatory Network Modelling APC IL2 IL2RA IL-21 IL2RB PMC5983613__F5 Leptin is a very important factor that links fatty acid Beta-oxidation with oocytes maturation PIM1 ACADS HADHB CPT2 HSD17B4 ECHS1 XPR1 ACADM PMC10998350__F5 Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway TERF2 ATM SIRT1 PMC9239034__F1 Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway STAT1 CCL20 USP25 OSM TRAF2 JUN PMC5921304__F6 Metabolic enzymes belonging to the most divergent group (protein sequence identity) in the context of carbohydrate metabolism TREH HEL-S-304 HEL107 PMC6436646__F2 Calcium signaling pathways and their effects on the calcium responsive percentage of chondrocytes TRPV4 CTRL PMC8301219__F3 Immune Checkpoint Inhibitors in Human Glioma Microenvironment TH GAL PMC2787458__F9 Wnt3a stimulates Src docking to, activation by, and phosphorylation of Dvl2 WNT3A LRP5 SRC DVL2 LRP6 PMC9168090__F9 Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine PI3 CAV3 HRC MCU CAV2 PMC3694614__F9 Free Radical-Producing Myeloid-Derived Regulatory Cells: Potent Activators and Suppressors of Lung Inflammation and Airway Hyperresponsiveness IL10 CD80 CCL22 PMC7655095__F7 The Gb3‐cSrc correlated mutant p53 signaling pathways METTL3 GEM PMC6955783__F5 RNAseq genes associated with NRF2-mediated oxidative stress response via IPA® PMF1 FOS GCLC FTH1 FTL HEL-S-107 BACH1 MAF HEL-S-94n FRK CCT7 JUN CLPP PMC6955783__F6 Hypothesized pathway and consequences of glutamine uptake in 2 h post METH STR microglia PIG59 SLC38A7 SLC7A11 GCLC GPX8 SLC38A1 SLC1A2 SLC7A6 HEL-S-64p HEL-S-44 SLC1A3 GLUD1 GLS PMC2818736__F1 Colorectal cancer (CRC) stem cell model APC SMAD4 TCF4 PMC5740974__F3 Cell entry and innate immune response TLR8 TLR7 IRF3 MYD88 PMC3609760__F5 Transcriptional Profiling of Rice Early Response to Magnaporthe oryzae Identified OsWRKYs as Important Regulators in Rice Blast Resistance CS CAD CCR1 PMC3380573__F1 Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment TSC2 IGF1 MTOR DEPTOR EIF4B IRS1 RHEB PMC5629314__F2 Pathway of de novo fatty acid synthesis in C FAT2 FAT1 FAT3 GLA FAT4 PMC5629314__F6 Abbreviated pathway of prenol and sterol lipid synthesis in C COQ4 COQ3 COQ2 COQ6 COQ5 PMC8567165__F5 Proteomic identification of ruminal epithelial protein expression profiles in response to starter feed supplementation in pre-weaned lambs CTH AKAP12 STOM POSTN ALB CD44 CFL2 PDLIM7 RPS7 SYNPO2 RPS19 ZYX PDLIM3 PMC8745585__F1 Homologous Recombination Deficiencies and Hereditary Tumors PALB2 BRIP1 RAD51D BARD1 BRCA1 ATM BRCA2 CDK2 RAD51 COIL ATR XRCC3 RAD51B RAD51C PMC3484431__F9 Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma MMP9 SHH SMO PMC5685659__F7 Diagram showing LMP1 signaling transduction to IRF4 activation IRF4 PMC8226784__F10 Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells TSC2 RICTOR TSC1 PTEN MTOR RHEB MLST8 PMC9135563__F5 Comprehensive Diagnostic Medical System Based on Notch1 Signaling Pathway to Inhibit the Growth of Small-Cell Lung Carcinoma APP SMS PMC7690808__F3 TGFB targeting factors that “lock” NK cell functions TGFBR1 CD226 MTOR CD69 PMC6826509__F4 Influence of high CO2 concentration on hormone and stomatal regulation CS IPP CPD PMC9634419__F4 Human stefin B: from its structure, folding, and aggregation to its function in health and disease DISC1 GSK3B MTOR PMC6685084__F1 The genetics of human hematopoiesis and its disruption in disease PDC PMC6525355__F1 Metabolic engineering strategies for producing PPD from xylose TH XDH IPP DMD PMC7690808__F1 Transforming growth factorB (TGFB) signalling pathways in tumorigenesis SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA HEL113 MTOR PMC4804493__F3 Death receptor signaling in SIVA TRADD TRAF5 TRAF2 FADD PMC5360883__F1 Diagram summarizing the effects of effector proteins on inflammatory signaling pathways in host cells NLRP3 TLR4 TRADD GSK3B TRAF6 MYD88 RPS3 TRAF2 IL1B TAB3 HEL-S-162eP PMC8848739__F4 Case report of recurrent fibromatosis with laryngeal involvement: Treatment based on network analyses of NGS data DDR1 PPM1M KCNA4 ELAVL3 TRIM46 CDC37 RALBP1 DDR2 KERA ROR1 MATK FER MUSK MDM2 RASA4 CSF2RA PMC9297685__F4 Possible mechanisms of cardioprotection resulting from stimulation of insulin receptor family members CGAS ULK1 IGF1 IGF2 PMC3684860__F7 Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish CRX NRL GNAT2 GNAT1 NR2E3 RORB OTX2 NR1A2 GUCA1A PMC5739070__F3 Optic Pathway Gliomas in Neurofibromatosis Type 1 SRC RAC1 MTOR PMC8785327__F4 Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain GAD2 SLC32A1 GLRA1 NRXN3 SLC4A1 PHGDH GABRB3 PCP4 PSAT1 NLGN3 GABRB1 HEL-S-51e SLC1A3 GABRA3 GABARAP GPHN PMC6693432__F5 Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis HEL-S-62p CS CFB MASP1 FCN3 C4A C3AR1 CR1 CLU CFI CD59 C9 CFD CFH VTN C7 C6 SERPING1 MASP2 CFP CD55 CR2 PMC11822654__F2 Efferocytosis in immune cells COX2 DUSP4 PTGS2 VAV1 GPR132 MYC RAC1 MERTK CD36 PMC7755516__F1 Intestinal epithelial cells (IECs) apoptosis in an acute and chronic state of intestinal diseases RIPK1 TRADD TRAF5 NFKB1 TRAF2 FADD PMC4130902__F1 G-protein—coupled receptors, hedgehog signaling and primary cilia GPR161 SHH PMC9301190__F2 Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies EGF CD47 CCR2 CSF1R CD163 CXCR4 CCL2 CXCL12 CD68 STAT3 PMC4130902__F2 G-protein—coupled receptors, hedgehog signaling and primary cilia SUFU EVC2 GLI3 EVC SHH EFCAB7 SMO PMC12108454__F1 Primary etiological factor for PMOP is estrogen deficiency RUNX2 SOST LRP5 LRP6 DKK1 PMC12108454__F2 New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress CTSK RUNX2 NFATC1 SIRT6 SIRT1 SIRT3 PMC12108454__F3 OS leads to the overproduction of ROS GPX4 RUNX2 HEL-S-28 SIRT6 SIRT1 SIRT3 PMC3432093__F11 Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells COX2 PTEN MTOR IL1B SIRT1 PMC3562715__F2 Oncogenic pathways in ABC-DLBCLThe stimulation of several surface receptors, including the B-cell receptor (BCR), CD40 or Toll-like receptors, triggers signaling cascades resulting in the activation of the NF-kB pathway CARD11 CD40 MYD88 CD79B CD79A IRF4 BCL6 PMC11822654__F3 Impaired efferocytosis in aging SIRPA CD47 TYRO3 MERTK AXL CD24 PMC5350184__F2 Genes involved in adipose tissue TLR‐ and insulin receptor signaling correlated with changes in plasma concentration of fetuin‐A and FFAs PIK3R1 IKBKE IKBKG CTSS MAP2K4 HEL-S-1 TICAM2 CNPY3 MAP2K3 SHC3 NOD2 TICAM1 SIGIRR CDC2 MAP3K1 UNC93B1 HRAS TLR10 TLR3 TCIRG1 STRADA PIK3R4 MLST8 TSC1 NFKB2 GRB2 MAPKAPK3 TIRAP TAB3 PMC5350184__F3 Genes involved in skeletal muscle TLR‐ and insulin receptor signaling related to changes in plasma concentration of fetuin‐A and FFAs IKBKE CTSS TICAM2 NRAS CREB1 IRAK4 FGFR4 ATP6V1C1 EIF4EBP1 RIPK2 PDPK1 TLR8 TLR7 MAPK1 PRKAB2 PRKAA2 EEA1 FGF18 TLR1 PIK3R4 TSC1 PIK3CA GRB10 MAPK11 SOS1 PIK3R2 TAB3 PMC10854713__F3 Phosphorylation regulates EMT and other functions of CRC cells BCKDK TNIK STAT2 LHPP APC GOLPH3 NR3C2 ITGA7 FGFR4 UBXN2A PTEN PPDPF SRC SPHK1 STAT3 PMC7399071__F2 DNA repair pathways XPC RAD51 LIG1 PCNA PMC10854713__F5 Glycosylation regulates the metastasis of CRC cells HEL-S-62p OGA OGT CD82 APC GSK3B EZH2 GAL MTOR hCG_1998026 ST3GAL6 ST6GAL1 PMC1435944__F6 Graphical Interface for the KnowledgeNet of candidate genes for hypertension CYBA REN EGFR INS CCL2 AGTRAP NPR3 NR1i1 NPY NPPA NPR2 PTGS2 PRSS8 NPPB NR0B2 ADRB2 IRS1 LEP EDNRA IGF1 CRH GNAS PPARG MME ADRB3 PMC11475559__F3 RhoA is overexpressed in cancer and promotes cancer progression via RhoA/ROCK2 signaling pathway ROCK2 CCND1 ARHA PMC3124103__F1 Transcription factor NFKB regulates the cellular response to inflammatory and oxidant stress, as well as stretch EGR1 PLG PMC7530265__F9 The potential protective effects of PA in LPS-induced intestinal barrier dysfunction NLRP3 TLR4 IL1B PMC9209463__F3 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases CARD11 EGFR VEGFA HBEGF ARHA RHO RAC1 PDPK1 FASN STAT3 PMC5828951__F2 Targeting Bromodomain and Extraterminal Proteins in Breast Cancer PTEN MTOR BRD4 PMC3207219__F1 ROCK signaling pathway with focus on survival and regeneration CNTF TSC2 TSC1 ARHA PTEN LPA LINGO1 RHEB PMC9475465__F3 Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy CXCR1 IL8RB PMC9209463__F2 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases ACACA EBP GSK3B MVK IDI1 HMGCS1 GPAM INSIG1 SCD DHCR7 ACSS1 FDPS ELOVL1 FDFT1 ELOVL3 ACLY FASN PMC7521217__F10 Based on the findings from Figures  and , we summarized the proposed underlying mechanism of oxidative stress downstream signalling pathway participated in brain damage in setting of acute IS ME1 C9 EME1 BAX PMC4569902__F7 Schematic view of the integration of Sema3-Nrp with the Hh signal pathway by controlling PKA and PDE4 PDE4D SHH SMO PMC6765251__F6 Putative metabolic map of a bacterium within the miscellaneous Bacteroidales metagenome reconstructed from the metagenomic data GLTP AMT MAL PMC3973656__F1 Curbing autophagy and histone deacetylases to kill cancer cells ULK1 ATG3 PMC12232871__F7 Some KRAS signaling pathways mediating PC mentioned in this review PEAK1 EGFR EIF5A MYC RALA SRC RPIA RALB MTOR PMC12232871__F8 Some p53, CDKN2A, and SMAD4 signaling pathways mediating PC mentioned in this review FOXA1 SMAD2 SMAD4 CREB1 CDK4 CDKN2A CDK6 HEL-S-68p PMC6797860__F1 Receptor composition of IL-12 family members and related cytokines STAT1 EBI3 STAT4 IL23R IL12RB1 STAT3 PMC7890593__F3 Identifying AKAPs in Cells and Tissues KIF23 THRAP3 INCENP DHX15 HCTP4 RBM25 NUP153 CHERP SART1 BCLAF1 SART3 DIDO1 SLU7 RBM14 HNRNPF PMC6912721__F6 Urea cycle and nitric oxide pathway ARG2 OTC ARG1 ASS1 ASL PMC8326113__F6 CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways CXCL16 ADAM10 CXCR6 PMC9028856__F1 Autophagy Process in Cervical Carcinogenesis: Role of Non-Coding-RNAs, Molecular Mechanisms, and Therapeutic Targets RICTOR ULK1 ATAD3A ATG12 ATG3 SQSTM1 RPS6KB2 MTOR DKFZp686F0183 RHEB PMC12232871__F5 Underlying mechanisms of several potential PC therapeutics via proteomic approaches UACA SLC7A11 SMAD2 MMP9 AK4 MTOR MMP2 SHH SP1 TGFA HEL-S-72p HEL-S-133P BAX PMC3155287__F1 Autophagy regulation TSC2 TSC1 PTEN RAF1 MTOR RHEB MLST8 PMC6776600__F1 Overview on complement activation and cascade progression HEL-S-62p C5AR1 C5AR2 CP PMC3268901__F1 The PTEN/mTOR signaling pathway PTEN MTOR TGFA PMC11019658__F3 Mechanisms by which DHM inhibits tumour cell invasion and metastasis PTEN CDH2 SP1 PMC9841179__F5 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases TBK1 CGAS IRF3 OTP PMC1815248__F5 Co-option of a developmental pathway by invasive tumors MMP2 RECK SCRIB PMC11019658__F1 Mechanistically, DHM inhibits tumour cell proliferation HMGB1 CXCR4 STAT3 PMC9841179__F6 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases PMC11019658__F2 DHM induces apoptosis in tumour cells and induces the associated signalling pathway NOTCH1 MTOR BAX PMC5454035__F1 Regulation of autophagy by nutrients and hormones via the mammalian target of rapamycin (mTOR) signaling pathway TSC2 ULK1 TSC1 ATG101 ULK2 UVRAG ATR IRS1 RHEB PMC9406056__F1 Neurotransmitters: Potential Targets in Glioblastoma NPY EGFR PTEN GAL PMC6757296__F2 Exosomes secreted by MM, NSCLC and PCa tumors carry different and abundant contents, which serve a key role in osteoclasts or osteoblasts, resulting in different metastatic lesions AREG EGFR PMC4822806__F3 Molecular mechanisms involved in autophagy and NAFLD.Notes: 1 TSC2 TSC1 PTEN MTOR PMC2063536__F7 ES cell–based model describing the ontogeny of NSCs APAF1 LIF FGF2 PMC4029773__F1 JAK-STAT signaling in adipose tissue function PDK4 PRL PMC9841179__F3 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases TBK1 CGAS IRF3 PMC9841179__F4 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases TBK1 KAT5 CGAS ULK1 HDAC3 MUL1 TRIM29 CLU RNF5 TRIM13 TRIM38 RNF26 TRIM32 USP14 SENP7 TRIM56 PTPN1 TTLL6 TTLL4 SYK CDC2 RNF111 OTUD5 PPP6C PMC10139189__F1 Migration and invasion of GBM cells is related to the inherent capacity and the cellular interactions that occur on the migratory front ANGPT2 TH WNT3 SOX2 CX3CR1 LIF CXCR4 CD44 GSC CDH2 PMC7481416__F3 Different pathways in cancer targeted by p-PROTAC APC TCF4 PMC6539103__F2 Potential roles of aberrant activations of MAPK and PI3K signaling pathways in pathogenesis of PWS/SWS SRC GIP PTEN MTOR PMC2900889__F8 Possible fates of disulfide reduced SOD1 in the G93A/CCS mouse CS HEL-S-44 CCS PMC2966065__F1 Chemical structure of OHyW in tRNAPhe and its biosynthetic pathway TYW3 TYW1 GC TYW5 PMC6915928__F2 The results of protein-protein interactions were identified with STRING database MHC2TA CD37 CD48 LTB WAS CSF2RB ACAP1 TLR10 CYTIP APOBEC3H LGALS2 ARHGAP15 PTPRC ITK PRKCB CD27 TSHR BASH GRAP2 CD40LG CD3G LY9 ICOS CD3E PMC5658094__F6 Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury TLR4 MYD88 PMC4593030__F7 Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway PPARGC1A SETD7 NFE2L2 TXN PMC8070205__F5 Activation of canonical STING Pathway upon replication stress or DNA damage TBK1 CGAS ATM TREX1 RAD51 IRF3 BRCA1 PMC7593846__F7 Signaling pathway analysis based on the potential biomarkers (A) Summary of ingenuity pathway analysis with MetaboAnalyst NR1i1 IMPACT PTH PMC8070205__F2 Homologous-directed repair PALB2 GEN1 BLM BRCA2 SLX4 GC RAD51 RMI2 RMI1 WRN DNA2 BRCA1 PMC6689035__F7 Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells LAMP2 ATF4 PRMT6 OPTN PMC8637646__F2 Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle SLC7A5 TIGAR HEL-S-26 NRF1 MYC PTEN MTOR SLC38A1 PMC7017004__F1 Signal transducers and activators of transcription (STAT)3 and STAT5 signaling in epithelial ovarian cancer (EOC) and tumor microenvironment PTPRT LIF PMC8070205__F8 Progerin expression in HGPS leads to DNA repair defect, replicative stress, and inflammation through DNA sensing in the cytosol STAT1 CGAS RIF1 RAD50 RAD51 MRE11A BRCA1 PCNA PMC6387042__F1 Mammalian or mechanistic target of rapamycin (mTOR) complexes and signaling pathway of mTORC1 and mTORC2 TSC2 TTI1 ELF3 PTEN EIF4E GRB10 DEPTOR EIF4B RHEB STAT3 PMC7755516__F2 Lytic cell death pathways of intestinal epithelial cells (IECs) during the intestinal diseases NLRP3 RIPK1 GPX4 RIPK3 TNF IL1B FADD MLKL GSDMD PMC2754932__F6 Model of Udu function in DNA damage response MCM3 ATM PMC8228377__F1 Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses ELOC COA3 PMC7027041__F8 Signaling pathways under heat stress affecting bGCs functions: A network map of pathways significantly (P < 0.05) enriched after heat stress PLK1 AMACR HSP90AB1 HSPD1 RPS26 CCNG2 RPS24 CCND2 GNPTAB MRPL36 MRPL15 MRPL33 SUMF1 PLA2G15 HEL-S-11 MRPL23 GNG2 GHR NFYC EDEM2 GSTA3 RFXANK STAR PRKAB1 BAX RPLP0 CTSL SCARB1 FOXO3A RPRM FOS RNF186 RRAS CYP11A1 RPS11 RPL15 HRAS HDAC1 HEL-S-125m CASP3 TSC2 RAC3 NFKB2 HEL-S-64p HEL-75 TRAF2 PCNA BCAP31 PMC6044348__F1 Schematic illustrating the current working hypothesis on IFNT signaling in endometrial epithelia and stroma of the ovine uterus CTSL RSAD2 STAT2 IRF9 PTGS2 HSD11B1 STAT1 ISG15 CST6 SLC7A2 HEL-S-2 IGFBP1 TYK2 JAK1 B2M IFIH1 IRF-1 IRF2 PMC8205988__F1 Anti- or pro-tumorigenic function of adiponectin in colon cancer ADIPOR1 CXCL1 ADIPOR2 MTOR PMC9669913__F6 Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NFKB signaling pathway COL2A1 TNF SOX9 PMC8415555__F9 Effect of tonB Gene on the Virulence of Pseudomonas plecoglossicida and the Immune Response of Epinephelus coioides CS FH HEL-S-99n CAD TNF HEL-S-130P PMC9298504__F1 Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease ULK1 ATG3 AKT1S1 ULK2 MTOR DKFZp686F0183 RPTOR DNAJC6 NLRP3 UVRAG VPS35 SNCA ATG16L1 LRRK2 ATG12 GIPR AMBRA1 ATG101 ATG10 DEPTOR RHEB GLP1R MLST8 TSC2 PINK1 TSC1 SYNJ1 BCL2 PMC7136955__F1 Cancer‐associated fibroblasts: activin A adds another string to their bow SMAD2 SMAD4 PMC4183996__F4 Involvement of microRNAs (miRNAs) in epithelial-mesenchymal transition (EMT)-related metastasis EGF HGF SMAD2 ZEB2 GSK3B ARHA PTEN CDH2 PMC7408135__F2 Ether phospholipid synthesis pathway in peroxisomes GNPAT HEL-S-26 FAR1 PMC8372757__F4 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning ANGPT2 CDKN1A IRAK2 GRB2 SRC TRAF6 SYK PMC8372757__F5 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning TH BAD DPP4 APC ALOX12 PTEN MTOR CD81 IFNG NLRP3 CDKN1A BCR CD22 GRB2 SYK CD80 CD19 PMC6160013__F8 Anti-oxidant activity of GPx3 mediating lung cancer suppression GPX3 EGF EGFR CCNB1 PMC7761761__F8 Putative metabolic pathway for the production of derivatives of nitrogen-containing azaphilone red pigments in the marine-derived Talaromyces sp GHB3 CA4 H1-5 PMC5218767__F1 Defective Treg cell suppressive mechanisms in IPEX and IPEX-like disorders APC LRBA CD80 CTLA4 FOXP3 PMC11978843__F6 Analysis of DEGs related to energy metabolism, phytohormone synthesis, and signaling pathway MAX F2 F5 F3 CAD PMC6727143__F3 Ingenuity pathway analysis representation of the most significant pathway in ICH versus CTRL – T cell receptor signaling ITK FYN CSK LCK GRB2 TEC SHB CTLA4 PMC6999830__F1 Mitochondria as a regulator of inflammation NLRP3 TANK TRAF6 IRF3 IL1B TFAM MAVS PMC7503245__F8 Schematic presentation of the possible role of bone kynurenic pathway activation in the osteoblast maturation process ATF4 SOST CCND1 BGLAP PMC8636667__F4 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone FYN FRS2 PDK2 GRB2 SHE PMC8658259__F4 Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area TSC2 EGF TSC1 IGF1 ATF3 MTOR GHRH STAT3 PMC8636667__F1 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone SI NFATC1 TRAF6 PMC8392326__F2 Inborn Errors in the LRR Domain of Nod2 and Their Potential Consequences on the Function of the Receptor TRAF3 IRF3 CD80 NOD2 MAVS PMC7460564__F3 Enzymatic activity of prolidase affects various cellular processes PYCR2 PRODH MTOR PMC4595774__F1 Regulation of the Golgi via the GOLPH3 pathway GOLPH3L GOLPH3 MAJN PMC1356334__F7 Alignment of sequences adjacent to Y200 for human TRPV1–4 NGF SRC TRPV1 PMC3676171__F2 Bile acid synthesis, conjugation, and biotransformation CYP27A1 CYP3A4 CYP7B1 BAAT PMC7851184__F2 Proposed mechanisms of neoplastic transformation of small intestinal ILCs in refractory CD II IL15 NOTCH1 PCNA FOXP3 PMC7312214__F1 Innovative Potential of Statins in Cancer: New Targets for New Therapies SUFU MMP9 MYC SHH CCND1 BCL2 CDK4 RHO PTEN MTOR IPP BAX PMC6193418__F1 Cell‐intrinsic pathway of apoptosis APAF1 BCL2 BAX PMC3356019__F1 Emerging pharmacological strategies for CSCs targeting include self-renewal pathway antagonists and chemoresistance-reverting agents PTCH1 SMO PMC6598962__F6 Cooperation of 17-aminogeldanamycin (AG) and trametinib (TRA) or vemurafenib (PLX) a A schematic summary of molecular effects of TRA, and PLX activity, and 17-aminogeldanamycin-mediated HSP90 inhibition in melanoma cells BRAF EIF2D ATF4 EIF2A XBP1 PMC4404315__F3 Embryonic Stem Cell Self-Renewal IL21R EPOR CSF3R IL11 IFNGR2 OSMR PIM1 PIAS2 IL20RA CLCF1 CRLF2 GHR CTF1 SRC LEPR STAM2 PTPN6 IFNGR1 IRF9 IL20RB LIF IFNAR2 IFNAR1 CNTF CREBBP EP300 CISH PIAS1 IL11RA OSM PMC6078129__F1 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment TRADD FADD PAF1 BAX PMC6078129__F2 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment FADD MLKL BAX PMC12038969__F4 Correlation between PYGO2 and IL10 expression through the Wnt/Beta-catenin signaling pathway in ESCC progression IL10 PYGO2 APC EGFR CCND1 PMC4404315__F2 Embryonic Stem Cell Self-Renewal FGFR1 FGFRL1 FGFR3 SRC FGFR4 FGFR2 PMC2679749__F3 Control of autophagy E2F4 FOXO3A EIF2A MTOR PMC7887427__F7 Differential gene expression of EGFR pathway proteins in TPC1-deficient MEF cells compared with wild-type cellsColor code indicates gradual changes in expression PIK3R1 MUC1 IKBKE MAP2K4 EGFR NRAS RHO MTOR NCK1 STAT1 MDM2 SRC MAP3K1 CAMK2D VAV1 CAMK2G RAC1 HRAS CAMK1 CBL PIK3C2B PIK3R5 RPS6KB1 PAK1 GRB2 JAK1 RAF1 SOS1 SHC1 CDC42 STAT3 PMC1502426__F1 Chromophore regeneration in vertebrate and invertebrate photoreceptors LRAT RPE65 RPE PMC3469471__F2 Regulation of the human TRAIL gene FADD BAX PMC2926258__F3 Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation LRP4 LRP5 LRP6 PTH WNT10B PMC3355932__F2 Anaplastic lymphoma kinase signaling BAD ALK FOS GSK3B SRC JAK3 MTOR PMC2850388__F7 Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair LEF1 SOX2 SHH SOX18 DKK1 DKK2 TNLG7C DKK4 PMC11761272__F6 Protective effect of HDH against IAV via activation of the innate immune system STAT1 CGAS STAT2 ISG20 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 SIRT3 PMC8972670__F1 Characteristics of NLRs NLRP3 NLRP1 TNF NOD2 NLRP10 PMC6314075__F2 Nuclear factor of activated T cell (NFAT)c1-centered osteoclastogenic signaling network BTK SEMA3A SEMA6D NFATC1 NRP1 OSCAR DCSTAMP TEC TRAF6 SYK SIRPB1 PMC4019002__F1 Omega-3 fatty acids and dementia BAD IGF1 PDK2 INSR PMC12116884__F9 PF ameliorates neuroinflammation induced by ABO BDNF ARG1 SYP CD68 PMC8870839__F2 Iron in Porphyrias: Friend or Foe? ALAS1 AIP UROD UROS CPOX ALAS2 PMC9126665__F10 Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NFKB Signaling Pathway GCLM TLR4 KEAP1 GSTM1 AMELY MYD88 TNF PMC5398616__F3 Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle TRRAP ZBTB33 YWHAG ARPP-21 PMC3478427__F2 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act DHFR ARHA PMC4178426__F9 Vascular smooth muscle contraction pathway RET REL LAT PMC3478427__F3 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act GRB2 PMC4178426__F6 Cell cycle pathway HEL-S-11 ELL MAL PMC3564914__F1 Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (Humulus lupulus) BCAT1 BCAT2 IPP PMC5536301__F7 Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis GCLC H6PD HEL-S-64p HEL-S-304 PMC5955138__F1 Natural product based sensitization of GBM BAD MDM2 PTEN FOXO1 PMC7533754__F1 Mechanisms involved in gut microbiota-host communication NLRP3 FOXP3 PMC10150895__F2 Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers TWIST1 GC VEGFA CDH2 MTOR CXCR6 SOX4 CCND2 PMC8669998__F1 Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature TBK1 TLR9 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 JAK1 MAVS PMC4745742__F8 Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation ARHA RHO DPT PMC8860897__F1 Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy STAT1 SIRPA CD47 IRF3 IRF-1 STAT3 PMC12041090__F3 Mechanisms by which natural products ameliorate renal fibrosis TBK1 CGAS ULK1 SMAD2 SMAD4 PTEN ZDHHC11 ZBP1 SIRT3 TLR4 ALG3 IRF7 LRP5 AMBRA1 LRP6 CCL4 IRF3 RAC1 ZDHHC1 DEPTOR TSC2 TSC1 BCL2 JAK3 JAK1 SIRT1 PMC8589249__F1 CCR7 in Blood Cancers – Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target BTK CCL21 CCR7 SYK PLCG2 CCL19 PMC6438423__F4 Analysis of the PI3K/AKT signaling pathway based on the KEGG database HEL-S-1 MYC CDC37 PTEN MTOR TSC2 MAP2K1 MDM2 CCND1 RAF1 MCL1 RPS6 PCK2 EIF4B RBL2 PMC12041090__F2 TGFB/Smads signaling pathway STAT1 NODAL SMAD2 SMURF2 APC SMAD4 JAK3 JAK1 MTOR SMURF1 STAT3 PMC11035622__F8 Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma SLC25A51 PC HP ACLY CIT SLC25A1 MAL GLS PMC6679203__F1 Signaling in AML FLT3-ITD BAD GRB2 SYK EIF4E FLT3 MTOR PMC8901701__F1 Immunopathology and Immunotherapy of Inflammatory Skin Diseases CXCL1 CCR6 CCL20 CXCL8 TYK2 IL23R STAT3 PMC3942542__F1 Cyclic adenosine diphosphate ribose mediated Ca2+signaling TRPM2 STIM1 PMC6948255__F6 Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1 MMP3 CCND1 SFRP1 PMC5877599__F4 Wnt and other signaling pathways regulating pluripotency of stem cells ROCK2 TH BAMBI INVS TCF3 SOX2 SKIL NODAL DUSP9 LIF SOST LEFTY2 CER1 ARHA POR BMP4 HES1 NLK TEF REST STAT3 PMC5877599__F5 Hippo signaling pathway AFP AMOT AREG SMAD2 SMAD4 SCRIB LATS1 LATS2 NKD1 PATJ GIG8 AXIN2 RASSF6 SMAD1 PMC8692906__F2 Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization PLK1 ORC6 CD6 SMAD2 SMAD4 LIG1 STAG1 DBF4 ORC3 CDK7 STAG2 CDC45 ORC2 CDC20 MCM2 SMC3 CDK2 CD2 MDM2 CYC1 DNA2 PCNA SKP2 MAL PMC6863919__F5 Metabolic reconstruction of “Ca PDC IPP GLTP PMC5992490__F2 Actions of IGF-1 and angiotensin II in skeletal muscle BAD IGF1R IGF1 PMC7327986__F5 NRF2 signaling pathway in the context of environmental pollutants induced redox toxicity and its regulation KEAP1 EGFR PTEN HSF1 PMC4394695__F1 Nuclear distribution of the PI3K pathway IPMK PTEN AKT3 PMC3704172__F3 miR-181b and miR-146a induced in CAFs are involved in the regulation of the NFKB signaling pathway IRAK1 TRAF6 STAT3 PMC6428526__F3 EMT is Modulated by Multiple Cascades Through Several Networks SETD1A CDH2 SIRT1 PMC8979689__F6 Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway BACE1 SYP BAX PMC8330071__F8 TLR7/8 signalling affects X-sperm motility via the GSK3 A/Beta-hexokinase pathway for the efficient production of sexed dairy goat embryos TLR8 GSK3B GSK3A TRAF6 PMC2848307__F1 Survival pathways with their cross-talk and immune regulatory mechanisms are shown in this pictorial representation of the Reed-Sternberg (R-S) cell CDA MYC SRC CD40 IL6 MTOR STAT3 PMC4086757__F1 Classification of resistance mechanisms to BRAF inhibitors IGF1R BRAF NRAS CDK4 PTEN MTOR PMC4281955__F1 Telling the story of a gastric cancer through sequencing and functional studies CDH4 TGFBR2 CDH2 FGFR2 PMC3659509__F1 Intracellular effects of soluble mediators are mainly mediated through the interaction with specific receptors that link extracellular signals up to modulation of gene expression EGFR NR1C1 FOXO1 MAFA PMC2912204__F1 PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001 TSC2 TSC1 PTEN MTOR RHEB PMC6830079__F1 Cyclic GMP AMP synthase-STING (cGAS-STING) pathway signaling as activated by genomic instability TBK1 CGAS RELA RELB IRF3 PMC6830079__F3 Two faces of cGAS-STING signaling in cancer STAT1 CGAS CXCL10 APC CCL2 TNF STAT3 PMC7057487__F3 Conceptualized network for the 7 enriched neurotransmission pathways PLCL1 ATP2B4 MAPK9 SLC1A1 BRAF DLGAP1 MAPK10 GSK3B GRIA2 CACNA2D1 GRIK3 GRIK2 GAD1 CACNA1C SLC17A6 SCN7A PPP2CA MAPK1 KCNQ3 SCN1A GNB1 ADCY9 PMC4652019__F1 TLR4 signaling in obesity RAB8A TLR4 MYD88 PMC6086983__F4 Scheme of the mechanism by which pioglitazone (PIO) regulates hepatic metabolites, lipids and related gene‐expression patterns (italicized) PC LPCAT3 DGAT2 ACD TG CD36 HEL-S-5 PMC7956931__F2 Simplified overview of EGFR pathway, with numbers of studies included per EGFR pathway inhibitor target BRAF EGFR PTEN MTOR PMC2787898__F1 TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice TLR4 TRAF6 IRF3 MYD88 TIRAP PMC11870265__F5 MAPK signaling pathways, their activators, and inhibitorsrelevant to this study EGF EGFR PMC7363118__F12 RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination TBK1 IRF3 TRIM25 MAVS PMC11911240__F4 Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy TBK1 PRMT1 CGAS PTMS TRIM38 IRF3 TRIM10 PALM TRIM29 HAT1 DDOST PMC1483149__F1 Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony PC MTOR PMC11911240__F1 CGAS-STING-TBK1 signaling pathway TBK1 CGAS RELA RELB IRF3 PMC12116456__F3 VEGF-A/VEGFR2 axis drives HB pathogenesis via angiogenesis stimulation VEGFA SRC MTOR PMC8714735__F3 IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma AFP EPCAM CXCR4 SRC STAT3 CD24 PMC11276702__F7 Gene expression of plant hormone biosynthesis pathway in the intraspecific hybrid fruit of H DAO SI PMC8956559__F4 Adipose tissue: a neglected organ in the response to severe trauma? HMGB1 CFD UCP1 TNF IL1B TF PMC8637576__F6 Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes HGF IL2 CERK IFNG PMC2614485__F6 A simplified Hh signaling pathway, constructed from combined Drosophila and mammalian data SMO GAS1 SKI PMC7913072__F4 Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases BAD SMAD2 SMAD4 TNF TGFB1 FADD BAX PMC4707055__F2 CO2 sensing and CO2 regulation of stomatal conductance: advances and open questions HEL-S-11 CA4 PMC8571860__F6 Wheat transcriptome profiling reveals abscisic and gibberellic acid treatments regulate early-stage phytohormone defense signaling, cell wall fortification, and metabolic switches following Fusarium graminearum-challenge BAK1 BIN2 HMGCR PMC2797318__F2 Promising bone-related targets for rheumatoid arthritis therapy LEF1 APC LRP5 SMAD4 LRP6 DKK1 SMAD1 PMC11064406__F3 Intracellular copper distribution pathways ATP7B COX17 ATP7A ATOX1 HEL-S-44 CCS PMC10609905__F1 Vitamin D synthesis pathway NR1i1 FGF2 CYP24A1 MYH1 CYP27B1 PMC10604974__F3 Activation mechanism of the NLRP3 inflammasome NLRP3 MYD88 TNF MAVS GSDMD PMC10604974__F2 Autophagy in viral infection ULK1 ATG12 ATG3 AMBRA1 ATG101 ULK2 ATG10 MTOR ATG14 DKFZp686F0183 PMC3889557__F10 Schematic representation of eHsp90A signaling pathway PMC9699419__F2 Cluster C19MC in Pre-Eclampsia Development NLRP3 MMP2 CXCL6 DIPLA1 TNFAIP3 FOXL2 PMC7880238__F1 Key signals regulating YAP/TAZ activity AMOT TAOK3 TEAD4 LATS1 RHO HEL-S-31 LATS2 MAP4K1 TAOK1 TAOK2 TEAD2 MAP4K2 TEAD3 NF2 MAP4K3 SRC PMC6685594__F4 lncRNAs mediate drug and radiation resistance ULK1 IGF1R EGFR HOXA1 MCL1 MTOR TGFA SOX9 STAT3 BAX PMC7786191__F2 UPRER and UPRmt mechanistic commonalities and differences are described in this figure EIF2A ATF5 XBP1 CLPP PMC7880238__F2 Proposed strategies and small molecules (direct and indirect) that could promote or inhibit YAP/TAZ activity MAP4K2 MAPK4 AMOT MAP4K3 VGLL4 SRC CA3 ARHA LATS1 LATS2 HEL-S-31 MAP4K1 PMC11095602__F2 Senescence-associated lymphoma progression and drug resistance BTK SOX2 MYC JAK3 MYD88 EZH2 MTOR GATA4 STAT3 PMC5296610__F4 Most significantly relevant pathways and highly linked molecules relevant to the merged bionetwork CNR2 NNMT ESPN CP PMC6033972__F2 Canonical and non-canonical signaling of interferon-gamma RUNX3 RAC1 RAF1 CRKL IFNG STAT3 PMC9062079__F2 Lens Aquaporins in Health and Disease: Location is Everything! TRPV4 OSR1 TRPV1 PMC4700229__F1 Interactions between immunotherapy and targeted therapy APC EGFR GRB2 MTOR PMC9076866__F8 Mechanism by which Grem1 regulates the TGFB1/Smad2/3 signaling pathway in IVDD GREM1 SMAD2 SMAD4 PMC9610147__F1 Innate immune responses by rabies virus TBK1 STAT1 PML STAT2 IRF7 IRF9 IRF3 TYK2 IRF2 IRF-1 PMC5479833__F4 Current model for selective compound families to promote neuronal compensation in HD via a stress response system centered onto FOXO and its co-factors PLK2 TPH1 MEI1 FBP1 GSK3B POP1 CDK8 SOX3 UBXN4 CDC2 JAK1 KEL OSM NR1H3 SIRT1 PMC8391764__F2 Platelets, Not an Insignificant Player in Development of Allergic Asthma AHR MMP2 PF4 MMP9 IL33 TSLP BDNF CD69 PMC4117150__F3 The Sonic Hedghehog (Shh) signalling pathway: Activation of signalling pathway is connected to various transmembrane proteins (Ptc, Smo), transcription factors (Ci/Gli) and protein kinases (Su(fu), fu) (Reproduced with permissions from Reference 31) SUFU SHH SMO PMC11064406__F4 Molecular mechanisms of cuproptosis FDX1 LIAS ATP7B COX17 ATP7A DLAT PMC2712626__F1 The Double Life of Irs TG IRS1 FOXO1 FOXA2 PMC9556833__F4 Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle APOA5 ATE1 SH2B2 TBC1D4 CRK HEL-S-61 IRS1 APOE PMC3376640__F6 Proposed Model of Psoriasis Pathogenesis in the Presence of Psoriasis-Specific CARD14 AlterationsAfter an inflammatory trigger, alterations in CARD14 induce activation of NF-kB IL36RN TRAF3 CCL20 IL22 TNF TRAF2 CARD14 PMC9519816__F2 Exploring the role of Nrf2 signaling in glioblastoma multiforme MAF KEAP1 GSK3B JUN NQO1 PMC3711071__F1 Function and regulation of AMPK leading to tumor suppression TSC2 ULK1 TSC1 XPC ULK2 MTOR PMC6960354__F1 Kynurenine pathway of tryptophan metabolism KYNU KMO IFNG PMC12111917__F7 Signaling pathways activated by exogenous sVASN treatment in different cell types AMOT EFNA1 EGFR MAPK3 CREB1 BCL2L1 FGFR2 OSMR HES1 ITGA2 INSR TEAD3 CSF1R FGFR1 ATXN1 MAML2 LAMA5 PARD3 LLGL2 WWC1 YAP1 CTNNA1 LAMA4 IFNAR1 WWTR1 HDAC1 PKN1 IKBKB PATJ PDGFC ITGB8 EFNA5 NFKB1 PLA2G4C WNT10A SMAD1 STAT3 PMC7310537__F6 Phosphorylation of HH pathway components after 15 min treatment SAG IFT140 IFT172 MTOR ADCY3 PRKCA SUFU EVC SMO PSMD4 PSMD1 ADRBK1 INPP5E PSMD11 PMC3149747__F2 Extensive feedback and feedforward loops between Ras signaling and miRNAs TNFSF6 RREB1 APAF1 MYC SPRY1 BTG2 IRS1 RHOB SPRY2 PMC3553295__F3 Cocaine and Withdrawal on the Mouse Nucleus Accumbens Transcriptome CREBBP RAP1GAP PMC11657697__F2 Inflammasomes in the three stages of HSCT Mobilization HMGB1 VCAM1 CXCR4 S100A9 GSDMD PMC11657697__F3 Correlation between inflammasomes and HSCT TH HEL-S-92n PMC4777846__F7 Schematic diagram of LRP1/Wnt5a-dependent inhibition of intracellular cholesterol accumulation ABCG1 ABCA1 NCEH1 PMC11657697__F1 Inflammasomes are multiprotein complexes composed of several domains with distinct functions NLRP3 HMGB1 NLRC4 NLRP1 NLRP6 RHO S100A9 AIM2 GSDMD PMC6763609__F11 DEGs are potentially related to Alzheimer’s relevant pathways and functions HAPLN1 NTRK1 GDA DKK1 SERPINA3 PCP4 TNFSF10 PPP1R17 DLX4 ALDH1A2 THOP1 SCN1A MME PMC6373781__F8 The interactions involved in the alteration of DC function following exposure to F UNK CD83 PMC2994781__F1 Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis TH DHPS TF PMC11704410__F7 The function of Tanshinone in androgenetic alopecia GPRC6A DUOX1 DUOX2 DUOXA1 DUOXA2 PMC3749718__F7 The putative steps in the redox signaling pathway leading to adaptive activation of transcription factors and upregulation of the expression of cytoprotective proteins following contractile activity in skeletal muscle HSF1 PRX TF PMC4946323__F7 Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy CDK2 MDM2 CCND1 CDK4 ATR CDK6 BAX PMC8139422__F7 SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation STAT1 HEL-S-62p CD46 CFB RELA C1S ACE2 PMC7249691__F8 Schematic diagram illustrating the different in canonical versus non-canonical response to IL-12 STAT4 TYK2 IL12RB1 PMC11281156__F6 Proposed cellular signal transduction pathway of TCBPA-induced cell inflammation in Jurkat cells IL1A MAPK6 MAPK8 MAPK3 GPX1 IL17A HEL-S-44 IL2 MAPK1 IL6 TNF GPER PMC2675004__F1 Crosstalk via the NFKB Signaling System LTA CD40 TNF LTBR PMC10975890__F1 MAPK signaling pathway (KEGG: 04010) enriched in bovine fibroblasts infected with B CD14 EGF TRADD FLNA TRAF6 TNF NLK NF1 MAX GRB2 JUND TRAF2 MEF2C PMC11917101__F11 Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/Beta-catenin/TCF4 signaling in sepsis-associated encephalopathy WNT3 MPO TCF4 PMC3254631__F5 MiRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols CD14 EGF GNG2 APC LBP FGD1 CRK PXN PMC5240216__F3 IRE1ɑ-XBP1 is one of the arms of UPR that polarizes tumor-infiltrating myeloid cells into highly immunosuppressive populations XBP1 STAT3 PMC9632420__F7 Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway EGFR CDH2 PMC8899708__F5 New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology MMP3 CD40 MAP3K8 PMC8150754__F2 Therapeutic Strategies for Metastatic Triple-Negative Breast Cancers: From Negative to Positive APC MYC PTEN CTLA4 HIF1A MTOR PMC3690345__F2 Metabolic crossroads of iron and copper ATP7B STEAP3 COX17 HP ATP7A ATOX1 FES FXN HEL-S-44 CP CCS TFR2 PMC10241773__F2 Epigenetic regulation and therapeutic targets in the tumor microenvironment CXCL10 HDAC11 CCL2 CCR8 USP24 METTL4 YTHDF1 METTL3 S100A8 CCR7 CXCL9 CD40 CD80 EZH2 ARG1 PMC8379496__AF1 Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation CCNB1 CCND1 CDK4 CDC2 PCK2 PMC8466180__F2 Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future GPX4 SLC7A11 HEL-S-64p GSK3B MDM2 TYRO3 SLC3A2 DHODH IPP HMGCR STAT3 PMC10383069__F2 Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC3159521__F2 Pre-B-cell-receptor signaling is regulated by a feed-back loop via Ikaros and Aiolos BCR FLT3 PMC5504126__F2 Cholesterol synthesis and metabolism in astrocytes and neurons CYP46A1 LDLR APOE PMC7578258__F2 Metabolic rewiring and redox adaptation induced by BRAFi during melanoma progression BRAF PMC7033114__F8 IDO1 and TDO contributing to the malignancy of gliomas IDO1 AHR AQP4 PMC9339493__F6 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) SRC STAT3 PMC9339493__F2 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) COX2 APC WNT1 FZD2 STAT3 PMC2817017__F2 RAS-RAF-MEK-ERK signaling pathway GAB2 GRB2 PMC8537916__F2 Mitochondrial Contributions to Hematopoietic Stem Cell Aging NLRP3 SIRT7 WAS MTOR IL1B SIRT3 PMC7691524__F7 RA Metabolic pathways affected by DEAB and TTNPB treatments AOX1 CYP26A1 CYP26B1 RGR RBP4 RETSAT RDH10 DHRS3 ALDH1A2 PMC9339493__F4 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) CBX3 INPP4A STAT3 PMC4133096__F2 Role of 53BP1 during the cell cycle RIF1 ATM BRCA1 PMC9339493__F5 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) STAT3 PMC6421044__F3 Regulatory loop among Kaiso, Wnt11/5a and Suz12 SUZ12 PMC2905064__F2 Integration of oncogenic and tumor suppressor inputs by the GLI code in cancer NUMB REN PTCH1 MDM2 PTEN JUN PMC5648021__F2 Metabolic Instruction of Immunity CPT1A MTOR OPA1 PMC8666286__F9 CoCrMo‐Nanoparticles induced peri‐implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2‐ARE signalling pathway GPX4 SLC7A11 SLC3A2 PMC9433910__F3 Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS NLRP3 MAPK8 MAPK1 MTOR PMC2848014__F8 Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation HEL-S-102 OTP NR1C1 PMC6639367__F1 Cellular glycolysis and oxidative phosphorylation F2 TES PMC7669588__F2 Pathway for Nucleotide Excision Repair (NER) XPC XPA PCNA PMC7186465__F1 Anticipated mechanism of action of IL-17B in tumorigenesis TFF1 GSK3B TRAF6 PMC4535882__F7 Multiple Protein Kinases via Activation of Transcription Factors NFKB, AP-1 and C/EBPD Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes EBP AKT3 PMC8353216__F2 COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes ACE2 TMPRSS2 PMC3932224__F3 Summary of regulatory networks centered by typical 2-Cys Prxs EPO PGR HEL-S-97n MYC PTEN NOD2 TXN HEL-S-69p HEL-S-2a BTK CDK2 APP ABRA CYCS BAX PMC10523190__F1 Progress in the research of cuproptosis and possible targets for cancer therapy MTF1 FDX1 ATP7B ATP7A PDHA1 DLD DLAT HEL-S-5 PMC11852824__F10 Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth BAD BRAF FOS NRAS BAX PMC8080560__F2 Depiction of key proteins targeted by CRLs during cell cycle progression FOXM1 CDK2 CDK4 CDC2 CDK6 PMC7801270__F1 Melatonin signaling pathway in the occurrence and development of OA NAMPT IL18 NFAT5 SIRT1 PMC8082653__F4 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies YTHDF2 DGCR8 PHLPP2 EIF3A LHPP SMAD2 DROSHA ALKBH5 SOX4 NKAP FBXO45 YTHDF1 METTL14 SIAH1 METTL3 EZH2 P2RX6 NKX3-1 PMC4880841__F1 Summary of NDR/LATS kinase signalling functioning downstream of Ste20-like kinases and upstream of the Hippo effectors YAP/TAZ AAK1 LATS1 LATS2 PMC8082653__F3 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies YTHDF2 METTL3 BMF TRAF2 IGF2BP2 SEC62 PMC7955048__F5 Direct catalytic asymmetric synthesis of Alpha-chiral bicyclo[1.1.1]pentanes PC SHE PMC4933865__F6 Multiple modes of action of Mg2+ in attenuating Pi-induced VC in HAVSMC MGP CASR RUNX2 SMAD1 TRPM7 PMC12037972__F1 Overview of serine-glycine-one-carbon (SGOC) metabolic pathway PSAT1 PSPH PHGDH PMC11456611__F7 Colorectal cancer: therapeutic targeting of oncogenic signaling cascades TSC2 TSC1 CCND1 PTEN PMC5354739__F1 Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma ABCC3 GGH ABCC10 DHFR ABCC1 TYMS HEL-S-70p ABCG2 FPGS ABCC2 ABCB1 SLC19A1 PMC2688935__F3 Networks used to generate simulated data PLCG1 EGF NRG3 BAD AREG MYC MTOR HRAS CRK SHC2 PRKCA GRB2 GAR1 SOS1 NRG4 ARAF CBLC PMC7926039__F2 Fibroblasts involved in the EPAC pathway and connection with fibrosis SMAD2 SMAD4 RHO PMC10603966__F5 Schematic view showing melatonin-mediated actions in stroke NLRP3 TLR4 MPO KEAP1 TRAF2 SIRT1 STAT3 SIRT3 PMC8561765__F7 Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells MAF KEAP1 PMC11456611__F2 The diverse signaling cascades implicated in colorectal carcinogenesis BAD SMAD2 IGF2 TGFBR1 APC TGFBR2 MYC SMAD4 LATS1 MTOR LATS2 CASP3 ERBB4 ATM SUFU ERBB2 AXIN1 MDM2 GRB2 SMO FADD FASN PMC3466514__F1 S6K1 in ER-positive breast cancer EGF TSC1 IGF1R ERBB2 EGFR PTEN TGFA IRS1 PMC1667087__F9 F igure 9.— EGFR SPEN NEDD4 PMC6891198__F7 ALK and RET inhibitors promote HLA class I antigen presentation and unmask new antigens within the tumor immunopeptidome STAT1 RET ALK PMC4002321__F2 PI3K/Akt pathway involved in tumorigenesis BAD CCND1 PTEN EIF4E PMC10818876__F2 Signaling pathways triggered by traditional medicine-derived SCFAs NLRP3 AHR MYD88 HIF1A MTOR GSDMD STAT3 PMC6696851__F8 Schematic diagram depicting possible mechanisms involved in the anti-fibrotic effect of melatonin and PAA SMAD2 WNT1 LRP5 LRP6 TGFBI PMC4592520__F1 MicroRNAs in placental health and disease AGO2 DGCR8 DROSHA PMC3048826__F9 Hsp72 is an important intracellular protein to inhibition of HMGB1 release and proinflammatory function in macrophages () HMGB1 IL16 PMC5352135__F8 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis CDK2 GC DVL1 CCNE1 BAX PMC2842492__F2 Transcripts regulating the mammalian cell cycle are up-regulated in the proliferative-phase endometrial epithelium APC SMAD4 ORC3 CDK6 ORC2 CDC20 ATM CDK2 MDM2 CDK4 CDC2 ATR PCNA SKP2 MYT1 PMC6429142__F8 Tangeretin-induced apoptotic pathway in BFTC-905 bladder cancer cells BAD BCL2 BAX PMC4300205__F1 Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes NODAL SMAD2 PMC6026692__F2 Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation HMGB1 MFN2 TLR4 TLR9 VCAM1 IL1B PMC3048826__F8 Hsp72 regulates oxidative stress-induced HMGB1 cytoplasmic translocation and release HMGB1 LAMP2 HDAC1 PMC4786758__F3 Position of miRNA targeted genes (red box) in endometrial carcinogenesis pathway (KEGG) BAD ERBB2 HEL-S-28 APC EGFR GSK3B PIK3CA PTEN AXIN2 SOS1 AKT3 PMC9699401__F11 Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression ATF4 BBC3 DDIT3 PMC3481527__F3 CB1 cannabinoid receptor signalling and regulation of neural stem/progenitor cell proliferation GSK3B SRC RAP1GAP STAT3 PMC4452102__F1 TLRs in human gastrointestinal pathology: health condition and inflammation IRF3 IFNG PMC5069789__F2 Epigenetic mechanisms mediate DEP effects on asthma pathogenesis IL18 AHR EGFR CCL20 NOTCH1 CYP1A1 IL6 HIF1A TSLP TGFA PMC2974067__F1 Signaling pathways that regulate longevity in C KRI1 SGK1 PMC7400296__F1 Fibrosis regulation by RBM7 via NEAT1 ncRNA decay in the lung CXCL12 RBM7 PMC7016888__F4 Cell signaling determination of artery, vein and lymph identity FOXC1 HEY2 SOX18 PROX1 EPHB4 PMC4873349__F2 IPA canonical pathway Cell Cycle: G1/S Checkpoint Regulation with up-regulated genes in the IR-induced common translatome highlighted in pink MAX SUV39H1 ATM CDK2 MDM2 SMAD4 NRG1 BMI1 SIN3A ATR PAK1IP1 PMC10299070__F3 Core pathways involved in development of Peyronie’s disease and their interrelationships IGF1 SMAD2 PTCH1 SMAD4 SHH SFRP1 ARHA SMO DKK1 PMC7583981__F1 Pyroptosis canonical pathway and non-canonical pathway NLRP3 NLRC4 AIM2 GSDMD PMC7583981__F2 Oxidative stress and ER stress in inflammation in DKD NLRP3 NOX4 TXNIP IL1B PMC12249569__F1 Mechanistic model linking gut dysbiosis, insulin resistance, and autism spectrum disorder TRAF6 MYD88 TLR1 TNF IRS1 PMC7859757__F4 ER stress can be triggered by alcohol, bile acids, pancreatic toxins, and increased protein synthesis ATF4 EIF2A XBP1 PMC7551201__F2 RAGE signaling pathway EGF SMAD2 SMAD4 CCL7 MYD88 MTOR SOX9 TLR4 MMP2 MDM2 SP1 ARG1 S100A4 SLC39A10 IL1A MMP9 KLF5 LCN2 RAC1 IL6 RECK ENPP2 BCL2 ZC3H12A SIRT1 CDC42 PMC12040832__F1 Underlying protective mechanism of EOs against oxidative damage induced by chemical overexposure PC MPO KEAP1 SMAD2 BCL2 MTOR CYP2E1 BAX PMC5766484__F4 Expression of key biological pathways involved in M HEL-S-11 TEF HEL-S-99n LPO MRO PMC2666018__F12 Differential Requirement for MEK/ERK and SMAD Signaling in PAI-1 and CTGF Expression in Response to Microtubule Disruption EGFR SRC ARHA PMC7115204__F2 Signaling pathway of G-CSF in breast cancer MSI1 MMP2 RAC1 GPR49 HRAS MTOR TGFA BMP4 PMC5570234__F2 MinePath viewer for BM20 region normal versus high Alzheimer's disease based on the CERAD classification PRKCZ CHUK GNB5 ROCK1 WAS GNAI1 STAT1 ITK VAV3 PTK2B PREX1 PARD3 ELMO1 c-fgr SET FOXO3A ADCY1 GSK3A ARHA RAC1 HRAS CRK PLCB1 SHC2 PIK3R5 NFKBIA PAK1 RAP1A MAP2K1 PRKCB NFKB1 GRB2 RAF1 SOS1 NCF1 PXN TF CDC42 AKT3 PMC6468358__F1 ADRB2 signaling in prostate cancer VASP BAD ADRB2 MCL1 PMC11941040__F3 Acute inflammation and molecular pathways induced by red complex bacteria and Fusobacterium nucleatum in endothelial cells CD14 TLR4 OMP VCAM1 MYD88 TLR1 ABCA1 PMC9406806__F8 Nano Modification of Antrodia Cinnamomea Exhibits Anti-Inflammatory Action and Improves the Migratory Potential of Myogenic Progenitors TH FZD4 DDX5 CDH2 TCF4 PMC7214760__F1 Biosynthetic pathway of aromatic amino acids MTR GALP PMC8436866__F2 Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease ELF2 NLRP3 DKFZp666G145 ATF4 GSK3B TXNIP ABCA1 MTOR XBP1 BAX PMC7583981__F5 Pyroptosis contributes to interstitial fibrosis NLRP3 IL18 SMAD2 SMAD4 PMC5206730__F6 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial CD14 EGF PAK1 HGF NGF SRC RAC1 ARF6 CDC42 PMC7551201__F5 S100A8/A9 provides a premetastatic environment IL10 CXCL1 SMAD2 LCN2 SMAD4 CCL7 S100A9 TLR4 ENPP2 S100A8 ARG1 ZC3H12A SLC39A10 PMC7414267__F2 Pro-viral and antiviral roles of TRIM6 TBK1 STAT2 IRF3 TYK2 IFNAR2 TRIM6 JAK1 IFNAR1 VAMP8 TRIM25 MAVS PMC7551201__F6 S100A4 increased motility of tumor cells TLR4 CCND1 S100A4 PMC5206730__F7 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial SHE HEL114 CRK CRKL PMC7816137__F3 Met1-linked ubiquitin machinery in inflammation and infection TBK1 CYLD SHARPIN OTULIN PMC7816137__F4 Met1-linked ubiquitin machinery in inflammation and infection UBE2L3 CYLD SHARPIN IRF3 OTULIN MAVS PMC3231924__F1 Simplified scheme for TLR signaling in enterocytes TLR5 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR1 NOD2 TLR3 TLR4 NOD1 CSA2 TIRAP PMC5197954__F1 Intronic microRNAs (miRNAs) and the miRNA-488/ZIP8/MTF1 pathway are critically involved in the pathogenesis of osteoarthritis (OA) MTF1 SMAD2 PMC8827164__F5 Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis F13A1 PIK3CD RPS14 ITGB3 ITGA2B FOS PLCG2 RPS29 RPL8 PRKCB RPS2 LYN VWF RPL10A RPS6 RPL7 PMC10480466__F7 Lenvatinib inhibition of EMT in ICC cells CDH2 PMC5724804__F5 SIRT6 histone deacetylase functions as a potential oncogene in human melanoma NPC1 ATG12 CTSS ATG3 BAK1 SQSTM1 BCL2L1 CLN3 ATG10 TNF PMC8960222__F2 Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells NRF1 MYC TOX TFAM PMC6374178__F4 Possible neurochemical/molecular pathways for stress-induced synaptic remodeling in medial prefrontal cortex GC MTOR BDNF PMC11887407__F4 Oncogenic GNAS activation and downstream signal transduction SIK2 YAP1 BIRC5 APC MYC SIK3 LATS1 SIK1 SRC SHH CCND1 BNIP3L SMO STAT3 PMC10526836__F1 Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential IL21R GRB2 JAK3 JAK1 STAT3 PMC11587777__F1 Immunopathological interactions in tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) APC CXCL9 PMC5345529__F1 Interaction of VHL protein with HIF and other proteins including elongin B, elongin C and CUL2 VHL TGFA PMC3490581__F4 Illustration of fluxes in central carbon metabolism for metabolic phases II and III along the protein/ tradeoff CPM CP MAL PMC5344275__F4 Biological responses leading to angiogenesis driven by the HGF–Met pathway HGF STAT3 PMC4590678__F1 Genes involved in Parkinson disease and in the autophagy-lysosome pathway VPS35 SNCA LRRK2 LAMP3 FBXO7 ATP6AP2 HEL-S-130P RAB7L1 MEF2D PINK1 SYNJ1 TFEB HEL-S-67p TMEM175 SMPD1 HEL-117 SCARB2 VCP GPNMB PMC7465660__F5 Relationship between EBV proteins, hTERT, and NOTCH signaling pathway and the modes of action of compounds with lytic induction potentials ZEB2 EZH2 MSH2 BATF PMC5344275__F2 Signaling mechanisms responsible for promotion of cell survival mediated by HGF–Met pathway BAD HGF BAX PMC5344275__F1 Schematic structures of HGF (A) and Met (B) GRB2 STAT3 PMC8298384__F9 Anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice PTPN1 GSK3B IRS1 FOXO1 PMC7933474__F1 Schematic diagram depicting a proposal model of the complex relationship between autophagy and exosomes in the context of pancreas ductal adenocarcinoma (PDAC) and its environment TP53INP1 IL26 ADAM9 MMP9 PMC3491835__F7 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia TSC2 TSC1 MTOR RHEB PMC5476461__F4 Regulation of antioxidant production by HIF-1 GCLM PSAT1 SLC7A11 PSPH HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC6406290__F6 Network analysis of differentially expressed genes RAPGEF2 TSPYL2 PMC12065456__F3 Communication between cancer-associated fibroblasts and specific tumor cells via integrins THBS2 SMAD2 CXCR4 GC ARHA CDH2 CD36 PMC8753223__F7 Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation IGF1 MSC CXCL12 SBDS MX1 PMC12065456__F4 Summary diagram of the interplay between integrins and cancer stem cells in specific tumor types CD9 TET3 ERBB2 KLF4 GSC STAT3 PMC8777512__F1 O-GlcNAcylation links oncogenic signals and cancer epigenetics PGM3 OGA OGT GNPNAT1 GFPT1 PMC5515442__F8 Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells TSC2 SMAD2 MTOR RPE PMC12235270__F2 Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance YAP1 LATS1 LATS2 PMC12065456__F2 Pro- and anti-tumorigenic effects of integrins on interaction between endothelial cells and particular tumor cells PIGF EGF NCL HEL-S-28 RHO RAC1 MTOR COX2 MMRN2 VCAM1 SRC CD93 TRAF2 CDC42 CD36 PMC7226356__F1 Perforin-granzyme, intrinsic (mitochondrial) and extrinsic apoptotic pathway TNF BAX PMC11750448__F4 Network view depicting hub metabolites, their associated miRNAs, and the target genes within the corresponding metabolic pathway GGT7 GAD1 CYP2E1 BAAT GADL1 PMC11960544__F3 Exploration of the signaling pathway of extracellular matrix (ECM)-receptor interaction in stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) CD47 NPNT CD44 VWF CHAD DMP1 CD36 PMC8547806__F2 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG EGF APC PMC8547806__F3 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG TLR4 APC TGFBR1 PMC7728579__F2 Transsulfuration and H2S oxidation pathways ETHE1 SUOX PMC8539471__F3 Controversial Role of Adiponectin in Appetite Regulation of Animals ADIPOR1 POMC NPY ARC PMC5578419__F2 Experimental models of hepatitis B and C — new insights and progress CLDN1 NPC1L1 CD81 PMC3163776__F3 IRE1Alpha-XBP1 pathway in glucose homeostasis HEL-S-99n UNK DNAJB9 TRAF2 PMC3163776__F2 IRE1Alpha-XBP1 pathway in inflammation TLR4 PAIP1 TRAF6 IL6 TNF TRAF2 BAX PMC4273448__F7 The structure-function relationships of IRAK-M based on this study TRAF6 MYD88 PMC4817806__F8 Proposed mechanism by which DZNep epigenetically reactivates Wnt/Beta-catenin signaling to promote osteogenic differentiation of osteoporosis BMSCs WNT1 WNT10A EZH2 PMC5423221__F5 Metastatic niches in the bone marrow CXCR4 SRC CXCL12 CDH2 MTOR PMC4620719__F2 Cross-regulation of intracellular membrane-associated proteins and microRNAs in B cell differentiation ATG16L1 ATG12 DKFZp686F0183 PMC9687179__F1 Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription FBP1 ATF1 GIT2 PMC6651255__F2 STNM01 blocks the glycosaminoglycan synthesis pathway through RNA-induced silencing complex (RISC) activation CS GAL PMC4364402__F2 Models of peripheral and spinal itch circuitry GRPR ITCH PMC6059739__F3 Regulation of the Wnt pathway via YAP/TAZ DVL2 TCF4 PMC4445092__F2 Schematic presentation of testosterone-activated extra-nuclear signaling pathways SHBG EGFR SRC PMC6451008__F1 PTEN S-nitrosylation by NOS1 inhibits autophagy in NPC cells PTEN MTOR PMC7967197__F1 CyclinD/CDK4/6 involvement in overpassing resistance to aromatase inhibitors EGFR CDK4 MTOR PMC9021737__F5 De Novo Assembly of 20 Chicken Genomes Reveals the Undetectable Phenomenon for Thousands of Core Genes on Microchromosomes and Subtelomeric Regions CFB FLNA RELB TRAF3 HUWE1 PPP2R1A TRIM39 CLU BTK IL36RN KHSRP CACTIN SYK SND1 TXNIP TRAF2 AXL PMC4658488__F1 Cholesterol biosynthetic pathway and cholesterol synthesis inhibitors used in the current study PMVK IDI2 DHCR7 SC5D SOST DHCR24 MVK IDI1 IPP HMGCR PMC5859872__F2 Cooperative interactions between the tumour and surrounding cells in tumorigenesis MMP2 FOS EGFR SCRIB PMC5859872__F3 Non-cell-autonomous overgrowth TSG101 VPS25 SCRIB PMC3124126__F1 Molecular signaling cascades which normally control mTORC1 activity and may become dysregulated in B-cell lymphomas leading to aberrant mTORC1 signaling activation TSC2 TSC1 PTEN RHEB PMC5859872__F1 Cell competition mechanisms SCRIB ROBO2 PMC6421314__F1 Relationship between Fe deficiency responses in dicots and responses to pathogens (necrotrophs or biotrophs that elicit SAR) or to beneficial microbes that elicit ISR COMP PMC4313785__F1 Figitumumab (CP) is a biased agonist of the IGF1R that selectively promotes Beta-arrestin1 (Beta-arr1) signaling in cancer cells IGF1 IRS1 CP PMC3928074__F1 Phase II Trials of Single Agent Anti-VEGF Therapy for Patients with Chronic Lymphocytic Leukemia (CLL) STAT3 PMC3307977__F6 Schematic diagram of the FGF2-STAT3-PAX3 signaling pathway FGF2 PAX3 STAT3 PMC5430039__F4 Host miRNAs that favor viral replication via the inhibition of the Jak/STAT signaling pathway IRF9 JAK1 PMC11889548__F5 Abnormal Hedgehog (Hh) signal transduction caused by EFCAB7 mutation SUFU NKX2-5 EVC2 EVC EFCAB7 SMO GIP MYH6 PMC7865717__F3 RSV could prevent oxidative stress involved in the development and progression of ocular diseases such as age-related macular degeneration (AMD) FRK VEGFA RPE PMC7865717__F4 Proposed model of resveratrol action during oxidative stress in glaucoma RPE TFAM SIRT1 PMC8040975__F3 TSP1 and ligands in glucose metabolism and diabetes mellitus SIRPA CD47 TGFB1 UCP2 CD36 PMC8040975__F4 TSP1 in adipose metabolism and obesity CD47 TGFB1 STAT3 CD36 PMC5843355__F1 Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery ADSL GDA GMPR APRT PMC8804234__F3 Molecular Mechanisms of Clonorchis sinensis-Host Interactions and Implications for Vaccine Development BAMBI TLR4 IL33 MYD88 PMC4190578__F5 Metabolic pathways for carbohydrates, fatty acids and phenylalanine FRK UGDH CAD PMC3154472__F1 Identification and Phylogenetic Analysis of Heme Synthesis Genes in Trypanosomatids and Their Bacterial Endosymbionts FECH UROD UROS CPOX PMC6477175__F1 Distribution of target proteins of baicalin in the “Alzheimer’s disease pathway” CASP3 HEL-S-62p SNCA BAD HEL-S-11 FES LPL LBP APP FADD APOE PMC7370155__F1 HMGB1 mediated neuroinflammatory response in TBI HMGB1 TLR4 TRAF6 MYD88 IL1B TIRAP BAX PMC3076058__F2 Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction KRIT1 ARHA SMURF1 CDC42 PMC6477175__F2 Distribution of target proteins of icariin within the “Alzheimer’s disease pathway” CASP3 HEL-S-62p SNCA BAD HEL-S-11 FES LPL LBP APP FADD APOE PMC7370155__F2 HMGB1-mediated EBI post-SAH HMGB1 TLR4 TRAF6 MYD88 TIRAP STAT3 PMC9605147__F1 Let-7 microRNAs Are Possibly Associated with Perineural Invasion in Colorectal Cancer by Targeting IGF Axis IRS1 IGF2R INSR PMC6395431__F1 Biochemical pathway OTC ORC1L ALDH18A1 ARG1 ASL PMC4693271__F1 Toll-like receptors (TLR) 4-mediated signaling of innate immune responses TLR4 TRAF3 RELB TRAF6 IRF3 MYD88 TAB3 MAL PMC6126897__F2 Functions of iTreg in the TME PTEN MTOR FOXP3 PMC4693271__F4 Ubiquitination-mediated signaling cascades in canonical and non-canonical NFKB pathways TRADD SHARPIN TRAF3 RELB CD40 TRAF2 TAB3 PMC4989114__F1 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate BCO1 RDH10 ALDH8A1 HEL-S-4 PMC6477175__F3 Distribution of target proteins of dihydromyricetin within the “Alzheimer’s disease pathway” CASP3 HEL-S-62p SNCA BAD HEL-S-11 FES LPL LBP APP FADD APOE PMC6477175__F4 Distribution of target proteins of hesperidin in the “Alzheimer’s disease pathway” CASP3 HEL-S-62p SNCA BAD HEL-S-11 FES LPL LBP APP FADD APOE PMC11842335__F3 Activating the Nrf2/KEAP1 signaling pathway to counteract oxidative stress and subsequent inflammatory reactions, including mastitis, induced by LPS through the administration of bioactive compounds from an external source KEAP1 TNF PMC11842335__F2 Underlined molecular mechanism during mastitis development KEAP1 TNF PMC7887651__F4 Immunometabolic interplay in obesity IRF3 IRS1 STAT3 PMC6909602__F6 Schematic of the mechanism by which Alpha-synuclein induces the accumulation of microglia through CXCL12/CXCR4 TLR4 NFKB1 CXCR4 SRC CXCL12 PMC3449280__F1 An engineered eukaryotic protein glycosylation pathway in Escherichia coli AIG1 ALG1 ALG13 PMC10825793__F3 EBV-miRNAs modulating inflammatory signaling pathways CHUK FYN TRADD IRF7 FOS JAK3 TNF JUN MAVS VAV2 PMC8435254__F2 Serum L‐arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case‐control study DHH VIP PMC4957398__F2 Signaling of pexophagy by ROS, hypoxia and inhibition of PEX5 export from peroxisomes UBC ULK1 PEX5 ATM NBR1 PMC3228119__F1 PI3K/AKT/mTOR signaling network regulates cell survival, proliferation, migration, metabolism, and apoptosis, integrating the growth factor signaling pathway, nutrient status, and other oncogenic pathways TSC2 EEF2K RICTOR BAD TSC1 PTEN EIF4E MTOR IRS1 RHEB PMC8874739__F6 PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism PLCG1 PDE1B F2R PPP3CA ASPH PLOD1 TNNC1 CAMK2G ADRB2 TRDN ADCY8 STIM2 CALM1 PI3 FGFR1 MYLK2 GRIN1 BCR RYR1 PLCE1 SPEN HRC SPHK1 CASQ2 PMC4677817__F2 Contribution of Metabolic Reprogramming to Macrophage Plasticity and Function TRO ARG1 ASL PMC4383156__F5 The major pathways involved in the molecular mechanisms of cancer HEL-S-11 GRB2 CRK FADD CDC42 PMC1905066__F5 CRP and mannan-binding lectin (MBL) on complement activation HEL-S-62p C9 ME2 CRP C1S PMC6117622__F4 MAPK signaling pathway CD14 EGF DAO FLNA EGFR GCK TRAF6 NLK MAX MAFK GRB2 BDNF TRAF2 JUN BAP1 PMC11373554__F7 MetaCore enrichment pathway analysis of genes coexpressed with KDM5B in pancreatic cancer FOXM1 GRIP1 TDG EGFR FOXK1 ARHA CARF APP SHH HDAC2 BARX2 TCF4 TERT PMC11373554__F5 MetaCore pathway analysis of the coexpression gene network involving KDM1A in pancreatic cancer RAP1A ATM APC RHO RAC1 ATR CDC42 PMC5957297__F3 MAPK pathway in BRAF-mutant melanoma HGF BRAF EGFR NRAS PMC11373554__F6 Expression of the KDM5A signaling pathway in pancreatic cancer (MetaCore) TH RET SPO11 HGF RYBP ATM GDNF CDK4 ATR BRCA1 PMC5957297__F4 MAPK pathway bypass in melanoma BRAF PMC5957297__F5 MAPK pathway indifference in melanoma BRAF PMC9705963__F1 Ferroptosis in osteosarcoma: A promising future GPX4 LPCAT3 STEAP3 SLC7A11 HEL-75 SLC3A2 POR KDM4A TF STAT3 PMC6527835__F1 Schematic illustration of the mammalian ganglioside synthesis pathway GM2A HEXA UGCG B4GALT5 B4GALNT1 HEL-S-111 B3GALT1 ST3GAL5 PMC4118962__F1 Interleukin-1/Toll-Like Receptor-Induced Nuclear Factor Kappa B Signaling Participates in Intima Hyperplasia after Carotid Artery Balloon Injury in Goto-Kakizaki Rats: A Potential Target Therapy Pathway IRAK2 TRAF6 IRAK4 MYD88 PMC3439646__F1 Complement and dysbiosis in periodontal disease CD14 TLR4 CXCR4 GSK3B RAC1 TLR1 IRF-1 IFNG PMC7213603__F4 Schematic representation for a proposed pathway showing upstream regulation of EZH2 in SLE CD4+ T cells EZH2 MTOR DEPTOR MLST8 PMC11986939__F3 PPI network vs KIT EGFR SRC UMPS NR1C2 IL2 RAF1 INSR PMC4154952__F5 Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model EEF1A1 PPAN ARPP-21 EGLN1 DUSP11 CLEC4C FRK CLEC4A TP73 PECAM1 TMEM176B ZNF76 MRPL11 PMC9463134__F1 InterferonG receptor pathway: a new way to regulate CAR T cell-solid tumor cell adhesion JAK1 IFNG PMC4530463__F1 Basic biology and role of interleukin-17 in immunity and inflammation TRAF5 EBP TRAF6 TNF TRAF2 IL17RC TAB3 PMC8579641__F1 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior HMGB1 RIPK1 TLR4 CTSC SRC IL8RB SYK TNF PMC8579641__F2 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior HMGB1 TLR4 TLR9 HEL-S-76p MMP9 STAT3 PMC9204485__F1 Love-Hate Relationship Between TGFB Signaling and the Immune System During Development and Tumorigenesis SMAD2 GRB2 SMAD4 TRAF6 RHO FURIN MTOR TF PMC6362006__F7 Schematic depicting ghrelin’s proposed effect on contact dermatitis and psoriasis TRADD TRAF2 IL1B FADD PMC9371342__F1 Summary of the major components of the extrinsic and intrinsic pathways of apoptosis induction following viral infection CGAS ATF4 IRF3 TNF TLR3 BAX PMC4370699__F5 Activation of CNTF/CNTFRA Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo CNTF TSC2 TSC1 PMC5241776__F2 Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics HAPLN1 MOG PLEKHF2 LEFTY2 UCN MYC CRHBP HIF1A RPSA WNT4 DVL2 UBL4A PRKAB2 SFRP4 FOS TES ENG TNF HRAS VDAC3 THBS4 MYH6 RICTOR GGA1 GRB2 BANF1 PRKAG2 PRKCH SUMO1 CRHR2 HEL-S-182mP SMOC2 ARHGEF2 MTOR CCND3 DBF4 ELAVL1 CCND1 TUBA3E CD47 NR3C1 ARR3 ARHA LEF1 FBXO32 RELA JUND PXN INHBA PMC5086619__F1 Mammalian target of rapamycin complex 1 (mTORC1) pathway and translation initiation EIF4E MTOR DEPTOR EIF4B PMC2424294__F2 Induction and lifetimes of signal transduction proteins (and their mRNAs) at various positions in signal transduction networks TSC2 EPOR CYC1 CRAT PTEN TGFA PMC11240421__F13 CK1A interplay in the NFKB pathway TRADD YBX1 IRAK1 TRAF6 IRAK4 MYD88 RIPK1 BCL10 TRAF5 CYLD RELA TRAF2 OTULIN TAB3 PMC10755915__F6 Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism CYP27A1 MSR1 CD163 MT1G KLF4 ABCA1 PPARG ORM1 CD36 PMC4584235__F6 MiR-146 a/b effect on induction of endotoxin tolerance TLR4 RUNX3 TRAF6 MYD88 TNF STAT3 PMC6614380__F1 Pathways to B cell memory TLR7 BCR CD40 ICOS ELL PMC9315518__F8 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma AFP SOX2 GIG8 AMOT SMAD2 APC NID1 PMC5869528__F10 Cytokine-cytokine receptor interaction signaling pathway CDA CCR2 EGF EPO CCR3 FLT4 CSF3R CCL21 TPO IL26 KDR AMH IL22 CCL19 IL4 CSF2 ACTR2 KIT LIF LTB BMP7 IL6 TNF IL23R TNLG7C TSLP EDAR LEP LTA IFNK IL23A FLT3 IL20 OSM INHBB LTBR CCL3 XCL2 PMC8467693__F1 Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models WNT3A MYC CCND1 DKK1 PMC5869528__F11 Jak-STAT signaling pathway PIM1 EPO PMC9171628__F2 Rational Use of Complement Inhibitors in Kidney Diseases HEL-S-62p C4B_2 MASP2 PMC12146007__F15 Bioactive components-modified smart implants for vascularization and osteogenesis MAGT1 RUNX2 HDAC7 COL4A2 PMC5869528__F12 NOD-like receptor signaling pathway INA TRIP6 CCL2 NOD2 PMC12179907__F2 Epigenetic modification mechanisms in congenital scoliosis SORCS2 RUNX2 APC GSK3B RNF213 ARHA ROBO2 PTEN RAC1 COL1A1 MYST4 RHEB TSC2 TSC1 FGF23 SRC GSE1 ROR2 TNS3 PMC6548783__F3 IL-6 production by blood leukocytes is altered in the RA-like PsoA patient in response to immune activators NLRP3 TLR4 TRAF5 TRAF6 TRAF3IP2 TNF TRAF2 AIM2 IL1B NOD2 PMC7016982__F1 Regulation of YAP at the level of the extracellular matrix involves various proteins involved in stabilizing and activating YAP SRC PDLIM7 PMC7016982__F2 Pathways and interplay with regulate mechanotransduction in the context of chronic disease and polarity TRPV4 UCP1 PIEZO1 RHO IRS1 PMC6936658__F5 Significantly down regulated genes (from the current study; PLIN1, SORBS1, FABP4, etc) involved in the PPAR signaling pathway is highlighted in red color PLTP HEL-S-28 LPL PMC7758401__F1 Establishment, maintenance and erasing of 5mC in plants AGO2 AGO4 TES PMC7912637__F6 Mechanistic diagram for microglial IRF5/4 activation TLR4 TRAF6 IRAK4 MYD88 IL4 ARG1 IRF4 PMC11557232__F6 Model for the functions and acquisition pathways of acetyl-CoA in multiple organelles of Toxoplasma APC CIT MAL PMC8237569__F3 Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction DDN DHFR FGD1 PMC5226065__F4 Mechanisms underlying SQ induced self-renewal HEL-S-28 CCND1 RHO MTOR PMC206993__F9 SPARC-mediated regulation of and coupling to the TGFB signaling system SPARC CDK2 SMAD2 PMC9358627__F4 Association of ABCC2 haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients UGT1A9 CES2 CYP3A4 UGT1A10 IMPDH1 IMPDH2 UGT1A8 UGT2B7 ABCC2 ABCB1 UGT1A7 PMC6528834__F10 DUAL INHIBITION OF ERK1/2 AND AKT PATHWAYS IS REQUIRED TO SUPPRESS THE GROWTH AND SURVIVAL OF ENDOMETRIOTIC CELLS AND LESIONS CASP3 BAD GSK3B BCL2 PMC8623546__F5 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease TSC2 TSC1 MTOR RHEB PMC8326529__F9 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis MYB TSC2 CD37 BCR PTEN RBL2 RHEB CD19 PMC3035969__F5 Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression MOS TGFBR1 RELB MYC UNG GNG12 NLK NF1 NTF3 RAC3 MAX GRB2 ECSIT TRAF2 JUN PMC8623546__F6 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease STAT1 STAT3 PMC8623546__F7 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease APC BBS4 GSK3B BBS1 NPHP3 PMC4666325__F2 BCR signaling and downstream pathways BTK CARD11 BCL10 BCR LYN SYK MTOR PMC11743450__F3 Deregulated cell signaling pathways targeted by Bergenin TLR4 MDM2 HIF1A MTOR STAT3 PMC8623546__F9 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease SUFU PTCH1 SMO PMC8326529__F1 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis JUN IL1B PMC6180204__F1 Negative effects of resveratrol on NFKB via several pathways in SCI RIPK1 TLR4 TRADD MYD88 CSA2 TIRAP PMC7793647__F2 Major signaling pathways of GILZ FOXO3A GC IL6 TNF JUN IL1B CPO PMC12108254__F2 Steps involved in irisin production and the molecular cascades underlying its biological functions TLR4 UCP1 MAPK3 SREBF2 CASP9 MAPK1 MTOR BDNF NTRK2 STAT3 PMC8321552__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) for the nucleotide excision repair pathway CETN2 MYC SMAD4 PTEN MTOR CDK7 MLH3 SIAH1 PERP ATM MSH6 MDM2 MSH3 MSH2 XPC SSB FUS RFWD2 PMS2 CASP3 MCM2 SMC3 CDK2 XPA ATR PCNA MYT1 PMC9033023__F1 HSP90 mediates IFNGamma-induced adaptive immune resistance in pancreatic cancer STAT1 TSPAN5 IFNGR2 JAK1 IFNGR1 IFNG PMC3616003__F10 MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators IRX5 KCNA5 KCNA4 PITX2 GATA6 SIX1 MYH7 GATA4 MYH6 KCND2 KCNJ2 SCN1B SCN5A MEF2C HEL-S-133P PMC6540009__F6 Scheme of the effect of pioglitazone on CKD-mediated ER stress in CKD-MSCs MFN1 ATF4 MSC EIF2A OPA1 PMC2669301__F1 Tyrosine kinase network regulating mast cell activation STAT1 KIT BTK LAT2 GAB2 VAV1 LYN GRB2 SRC SYK PMC3092918__F1 Metabolic network used for metabolic flux analysis GAL CIT GLCE MAL PMC5884123__F8 Schematic diagram demonstrates the proliferation and apoptosis pathways including the upstream and downstream cascades activated by VEGFC in the GC-1 cells VEGFC EGR1 FOS CCND1 PMC514912__F7 Model showing the cooperation of the BLM and the FA pathways in the response to replication arrest induced by either DNA crosslinks or UVC and HU exposure FANCD2 BLM MRE11A PMC11053446__F10 KEGG pathway analysis for DE mRNAs in tracheal tissues from chickens infected with IBV DMV/1639 or IBV Mass41 CD14 CTSK TLR9 IRF9 TRAF3 TRAF6 IRF3 RAC1 MYD88 TLR3 CPO PDC CTRL LBP CD40 TYK2 CD80 FADD TIRAP PMC4453937__F5 Summary of SIRT1 regulating the apoptotic upstream pathways within a cardiomyocyte in exercise-trained SD rats BAD IGF1 PMC8929692__F4 Major metabolic pathways upregulated in the cells utilizing 3-hydroxybenzoate, 4-hydroxybenzoate or hydroquinone as a sole carbon source CORT SHE DES MGA CPO PMC10917925__F2 Pathways included in the model NRP1 SRC PTEN HIF1A CIT HES1 PMC11513379__F2 Nanomedicine in HNSCC therapy-a challenge to conventional therapy EGF IGF1R EGFR PTEN MTOR MAP2K6 COX2 RET PAK1 GRB2 SRC TGFA PCNA STAT3 PMC2864453__F1 Nuclear factorKB (NFKB) can be activated by a multitude of different stimuli, like TNFA, LPS and CD40L CD14 TLR4 RELB CD40 PMC7865812__F1 Contribution of transcription factors (TFs) to disease progression SOX2 ASCL1 MYC RB1 HIF1A SOX8 XBP1 SOX7 SOX9 SOX4 SOX3 FOXA1 TWIST1 SOX5 EZH2 SOX6 PMC7339106__F3 Tumor expressed CD200 inhibits the expansion of myeloid cells in TME CD200 PMC4170615__F6 Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma TNFSF6 MAX HEL-S-11 CRK JUN PMC5472345__F1 The NAD+ salvage pathway and its control by the circadian clock NAMPT NHLH2 SIRT1 FOXO1 STAT3 PMC4761106__F2 Hereditary Melanoma: Update on Syndromes and Management - Emerging melanoma cancer complexes and genetic counseling ACD TF TERT BAP1 PMC10758965__F2 Regulatory mechanisms of one-carbon metabolism enzymes MTHFD2L FOXM1 YBX1 SHMT1 MYC MTHFD1 PHGDH MTR PSAT1 ATF4 DHFR TYMS PSPH HEL-S-51e MTHFD1L PMC3368374__F1 In young muscle, abundant serum IGF-I can stimulate protein synthesis by activating Akt/mTOR/p70S6K pathway TSC2 GGH IGF1 SMAD2 MTOR RHEB PMC6739326__F8 Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKA signaling pathway FGF21 FGFR1 CAMKK2 PMC8880314__SF1 Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity SPTLC1 ASAH2 UGCG DES SPHK1 SPHK2 KDSR HEL-S-5 PMC5164846__F2 Fine-tuning vascular fate during endothelial-mesenchymal transition FRS2 SMAD2 TGFBR1 TGFBR2 PMC8697445__F1 Enhanced production of Gamma-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation CIT MAL PMC2292640__F1 SARS CORONAVIRUS AND INNATE IMMUNITY STAT1 STAT2 IRF9 TRAF3 RIGI IRF3 TYK2 IFNAR2 IFNAR1 ACE2 TLR3 MAVS PMC8406474__F2 NRF2 signalling pathway: New insights and progress in the field of wound healing MAF KEAP1 RBX1 NQO1 PMC8406474__F3 NRF2 signalling pathway: New insights and progress in the field of wound healing NLRP3 KEAP1 GCLC AIFM1 PGAM5 MTOR SIRT3 PMC6471541__F11 Proposed schematic depicting the signalling pathway via which TGFB1 promotes the osteogenesis and migration of osteoblasts MMP2 RUNX2 MMP9 PMC10758965__F3 Regulatory mechanisms of one-carbon metabolism enzymes ATF4 MYC ATF3 KDM4C PMC11018843__F4 Amyotrophic Lateral Sclerosis (ALS) and cytosolic DNA sensors TBK1 BTK CGAS HEL-S-44 DDX41 IRF3 C9orf72 PANX1 PMC10758965__F5 Regulatory mechanisms of one-carbon metabolism enzymes MTHFD2L ADSL SHMT1 DHFR TYMS PAICS MTHFD1 HEL-S-70p HEL-S-51e PCNA MTHFS MTHFD1L PMC11018843__F1 Main cytosolic DNA sensors and their downstream pathways TBK1 CGAS CCL26 CXCL10 RIPK3 DDX41 IRF3 CCL5 CCL2 MTOR DKFZp686F0183 ZBP1 BTK RIPK1 SEC24C FADS2 CCL20 WIPI2 TRAF2 AIM2 FADD MLKL IFI16 PMC11018843__F2 Alzheimer’s disease (AD) and cytosolic DNA sensors TBK1 STAT1 CGAS PQBP1 STAT2 CXCL10 IRF3 IL6 IFNAR1 AIM2 PMC6070613__F8 Triptolide signaling pathway CDK2 BAX PMC11018843__F3 Parkinson’s disease (PD) and cytosolic DNA sensors TBK1 PINK1 CGAS TOMM40 IRF3 IFNAR1 AIM2 IFI16 PMC6476043__F1 Proposed schematic representation of the immune response to MERS-CoV infection and how the invading virus is processed during an infection IL10 IRF7 CXCL10 TRAF3 TRAF6 IRF3 IL6 MYD88 TLR3 TLR4 IL2 IL-21 IL4 PMC8484489__F3 AP2/ERF, an important cold stress-related transcription factor family in plants: A review MYB ICE1 ERF CBL PMC4076637__F6 CDK4/6 is downstream of multiple pathways ERBB2 CDK4 CDK6 PMC5853807__F5 Proposed model of immunopathogenesis of Borreliella burgdorferi during early cutaneous infection IL10 IFIT3 RSAD2 IRF7 CXCL10 S100A9 TLR1 MX1 FOXP3 IDO1 KYNU KMO LILRB2 S100A8 LILRB3 CXCL9 CXCL11 CD68 PMC11770944__F3 Relationship between common targets of wogonoside and AS therapy and the top 15 enriched targets of the KEGG signaling pathway PDE4D LTA NR3A2 ATM PTGS2 RELA RAC1 TNF LAT PMC4836210__F4 Graphic representation of apoptosis signalling pathways TRADD APAF1 FADD BAX PMC5127718__F2 Endocytic Pathway in Microglia During Health, Aging and Alzheimer’s Disease TFEB M6PR OSTM1 RHEB PMC5513689__F1 Alcohol’s effects on the hypothalamic–pituitary–adrenal (HPA) axis and the stress response POMC IL18 AVP TNF PMC3712543__F4 Somatic variations in genes encoding proteins of the KEGG “Melanoma” signaling pathway EGF BAD FGFR1 PDGFA EGFR POR HRAS ARAF PMC10778204__F2 Representation of the important miRNAs that effectively regulate the Notch signaling pathway in glioblastoma NOTCH2 NOTCH1 DLL3 UVRAG PMC7415199__F2 Hypothetical diagram of the possible targets where melatonin may act against SARS-CoV-2 infection in the CNS NLRP3 IL1B TMPRSS2 STAT3 PMC2898418__F10 Schematic pathway of IL-8-mediated NAADP formation by CD38 in LAK cells PLCB2 LCK GC TRPM2 PMC4836210__F7 Graphic representation of apoptosis and viral replication BAD TRADD EIF2A FADD HRK PMC11011519__F2 NFKB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury HEL-S-62p CLIC1 STAT3 PMC8741374__F4 Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway EGF MPO THBD FOS EGFR CXCL10 MAPK14 MYC PON1 PTGER3 CCL2 RB1 PTGS1 IL15 MMP3 PLAT CYP3A4 RELA CRP BCL2 CD40LG NOS2 SELE BAX PMC6563602__F1 Complement system as a biomarker of disease activity and response to treatment in multiple sclerosis HEL-S-62p C9 C4B_2 C7 C6 C1S C4A PMC5582909__F2 RAS pathway status in human DKD, based on urine concentration and enzymatic activity of RAS components CTSG CTSA ACE2 PMC6239977__F2 Calcium-calmodulin-calcineurn-NFaT-DYRK1A pathway to human beta cell proliferation FOXM1 CDC2 CDKN1C DYRK1A PMC2592633__F1 RNAi pathways in Drosophila AGO1 AGO2 MAEL DROSHA PMC10536099__F6 Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections STAT1 OAS1 IRF9 JAK1 IFNLR1 IFIT1 PMC3240659__F3 Repeated Small Perturbation Approach Reveals Transcriptomic Steady States PTGS2 TGFBR2 GADD45A SEMA3B MCM7 CNN3 SLC38A1 CASP3 ZFP36L2 GIG8 CDKN1A UGCG PMAIP1 EMP1 PMC5897151__F3 Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease PINK1 LRRK2 TFEB HEL-S-53e ALDH2 MAL HEL-S-162eP PMC5482974__F3 Protein traffic steps mediated by PACS-1 and PACS-2 SYK PACS1 FURIN ARF6 ADAM17 PMC5482974__F4 PACS-2 Akt site and NLS together modulate membrane traffic, TRAIL-induced apoptosis, MAM integrity and the response to DNA damage EGF ATM SIRT1 ADAM17 BAX PMC7692234__F4 Hypothetical host-cell signaling pathways linking Cryptosporidium parvum infection and tumorigenesis APC IQGAP1 PMC9099149__F1 Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal TIAM1 SRC ARHA RAC1 TRIO PMC8457726__F1 Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways ANGPTL4 APC NOTUM SOST BCL9 PMC8457726__F2 Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways CDX2 RYK RHO SIAH2 PMC4276949__F1 Hypothetical model of HGF/SF activation in cancer HGF KLK4 TMPRSS13 HAL KLK5 PMC9641817__F4 Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease IDO1 PDC PMC7312818__F3 Role of miRNAs in the host–pathogen interaction TRAF6 MYD88 ACE2 CFTR PMC11781169__F7 Proposed mechanism underlying TRIM32 in enhancing neuronal ferroptosis after SCI GPX4 ATM TRIM32 PMC11673384__F1 Driver mechanisms of ferroptosis LPCAT3 STEAP3 FACL4 POR PMC5494096__F4 Pipeline of cell cycle and MAPK signaling pathway BAMBI NODAL ORC6 PITX2 SMAD2 APC MYC SMAD4 ARHA DBF4 ORC3 CDK7 CDC45 ORC2 IFNG CDC20 CDC6 SMC3 CDK2 MDM2 ORC1L PCNA SKP2 MYT1 PMC4149353__F5 Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms VAMP2 CENTA2 PMC6747522__F2 Canonical and non-canonical signaling of FGF23 FGF23 FGFR4 FGFR2 PMC9221492__F1 Synthetic Vulnerabilities in the KRAS Pathway TIAM1 RASSF1 GRB2 RHO RALBP1 MTOR ARF6 CDC42 PMC7318172__F5 Graphic showing the signalling pathway by which SYT4 regulates melanogenesis via Ca2+ influx SYT4 CAMK4 DCT TYRP1 TRPM1 PMC11845729__F5 Expression pattern of differentially expressed genes involved in the Wnt signalling pathway, an ancient and evolutionarily conserved pathway regulates the cell migration, polarity, neural patterning and organogenesis during embryonic development ROCK2 NLK APC SOST SMAD4 F11 SKP1 ARHA COIL CCAR2 PMC8238150__F1 (Pro)renin receptor in the kidney: function and significance COX2 AVP AQP2 LRP6 MPEG1 PMC3691184__F5 Integrated miRNA-mRNA Analysis Revealing the Potential Roles of miRNAs in Chordomas NLK MAX FLNA TNF TRAF2 MEF2C PMC2635127__F2 JNK/p38 non-Smad pathway SMAD4 TRAF6 PMC2635127__F3 Small GTPase non-Smad pathway SMAD4 ARHA CDC42 PMC2635127__F1 Erk non-Smad pathway GRB2 SMAD4 PMC11884060__F6 Map of the metabolic pathways related to the differentially expressed genes in strains S26 and S26-AE2 under 20 g/L and 100 g/L glucose conditions FBP1 ENO1 ENO2 GPD2 tal-1 GPD1 HEL-S-68p PMC2635127__F4 PI3K/Akt non-Smad pathway SMAD4 MTOR PMC8816882__F2 Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target NLRP3 RIPK1 GPX4 RIPK3 TNF FADD MLKL GSDMD BAX PMC5607088__F1 AT1 receptor signaling pathways in the cardiovascular system EGF EGFR HBEGF RAF1 EIF4E MTOR ADAM17 PMC8569258__F2 Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects TRADD GRB2 INS BCL2 MTOR TRAF2 INSR FASN BAX PMC6048025__F8 Regulatory effects of androgen on TGFB1/Smad signaling pathway and Nrf2-ARE signaling pathway MMP2 KEAP1 NQO1 TGFBI PMC3514454__F7 Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo SP1 PMC3425523__F4 Genes known to cause kidney cancer and their relationship with the mammalian target of rapamycin signaling pathway TSC2 FLCN TSC1 HGF FH FNIP2 VHL FNIP1 RHEB PMC10454862__F10 S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NFKB/NLRP3 Inflammasome Signaling Pathway NLRP3 S100A4 GSDMD PMC4467434__F6 Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer BMPR2 PC SKIL BMPR1A SMAD2 TGFBR1 TGFBR2 SMAD4 SMAD1 DKFZp781O1323 SMAD9 PMC2919370__F4 Fanconi Anemia Proteins and Endogenous Stresses ATRIP FANCA ATR FANCE PMC7728580__F2 Role of H2S in HCC EGFR MTOR STAT3 PMC2757945__F9 Molecular pathways by which WNT-Beta-Catenin and FGF regulate lung mesenchymal development LEF1 CCND1 FGF9 PMC9174948__F3 Chloroplast pH Homeostasis for the Regulation of Photosynthesis BCAT1 BCAT2 CYB PMC5684252__F1 An overview of signaling nexus of autophagy pathways ULK1 TFEB ATG12 WIPI1 LAMP2 BCL2 BNIP3 DKFZp686F0183 PMC2663408__F15 The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification AKR1C1 AKR1C4 AKR1C2 CYP2A13 PMC4063740__F8 Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway EGF EGFR GRB2 PMC7874400__F7 Critical role of miR-574-5p in ARDS pathogenesis NLRP3 HMGB1 TLR4 IL1B PMC7226631__F6 miRNA networks generated using IPA (Ingenuity Pathway Analysis) for the altered plasma miRNAs in colorectal cancer RECK PAH NR1C1 PMC6715616__F1 Anti‐ and proviral roles of autophagy in plants AGO1 REM1 NBR1 PMC4868689__F7 Protein kinase D2 contributes to TNF-Alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3B/Beta-catenin pathway in hepatocellular carcinoma GSK3B PMC11009445__F1 Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review LATS1 RHO LATS2 PMC9336466__F2 Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues HEL70 REL FADD LAT PMC7455639__F1 Genetic variant rs2494938 of LRFN2 gene is associated with non-small cell lung cancer risk in North-Indian population APC LRFN2 DLG4 PMC4690755__F6 Novel pathways of apolipoprotein A-I metabolism in HDL of different sizes in humans PLTP ABCG4 ABCG1 ABCA1 TG PMC11822051__F6 The proposed mechanism PC PLD2 MTOR PMC1413672__F6 Activation of PI3K signaling by PV HEL-S-28 PTEN MTOR PMC5423755__F1 FA/BRCA DNA damage response pathway PALB2 BRCA2 BRIP1 RAD51 RAD51C USP1 PMC3613856__F7 Association of Luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies DCP2 EIF4E DCP1A PMC12235269__F3 Fig. 3. JAK-STAT signalling pathway and JAK inhibitors in ulcerative colitis EPO LIF TPO TYK2 JAK3 OSM PMC7795031__F1 Shows how AhR ligands, such as air pollutants, FICZ, TCDD and kynurenine, including tumour derived, activate the AhR to modulate mitochondrial metabolism, partly via the regulation of the melatonergic pathway ASMT COX2 PDC AHR AANAT PMC8909928__F1 Fibroblast Growth Factor 23 and Osteoporosis: Evidence from Bench to Bedside FGF23 CASR NR1i1 PTH PMC6908928__F9 Gene network describing the possible mechanism of the regulation by CHST15 of cell proliferation and apoptosis as determined by IPA ILKAP TPM1 BMP2 EEF1A1 SAE1 APCDD1 PTHLH CLU USO1 RABL6 TIMP3 PMAIP1 CREM CCND1 LEPR BTG2 TGFA PMC9500187__F2 Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms MDM2 CDK4 CDK6 PMC6581700__F6 Molecular model for HTLV-1 and HTLV-2 regulatory proteins HBZ and APH-2 on Tax-mediated NFKB activation and TRAF3 interaction TRAF3 HBZ PMC4715896__F1 Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis COQ3 COQ2 COQ7 PMC8814816__F2 Targeting cholesterol homeostasis in hematopoietic malignancies CYP27A1 CH25H CYP46A1 MVK PMC8589410__F10 Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome FGA HEL-S-62p PMC3429540__F1 Emerging role of autophagy in kidney function, diseases and aging TSC2 TSC1 MAPK3 MAPK1 RRAGA EIF4EBP1 RHEB FKBP1A PMC6349439__F1 We shall overcome (drug resistance) some day ALK EGFR STAT3 PMC2909662__F1 Signaling pathways of TLR4 TLR4 RELA TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 MAL PMC6827255__F1 DNA-driven cGAS-cGAMP-STING signaling mediates innate immune response TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC7532048__F9 Mechanism diagram SOX2 KDM5B PMC3436837__F1 Boolean network model of the HGF-induced keratinocyte migration MMP10 AKAP12 HGF PLG ATF2 EGFR HBEGF PTEN RAC1 GAB2 CDK2 CCL20 CDC42 PMC5618532__F2A Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 TSC2 ULK1 BCL2 MTOR BAX PMC5727250__F3 Possible Wnt pathway‐related therapeutic targets in CLL LEF1 ROR1 PMC6939831__F4 Three enriched Ca2+-related pathways APC GRB2 SMAD4 FLNB PPP2R1B FZD1 RYR2 PMC4661858__F3 Inhibitors developed against EZH2 SET EZH2 AEBP2 EED PMC5727250__F1 Simplified overview of mammalian Wnt/B‐catenin and Wnt/PCP pathways LEF1 APC GSK3B MYC LRP5 LRP6 ROR2 RHO RAC1 ROR1 PMC4766307__F1 Recruitment and activation of bone marrow-derived fibroblasts in renal fibrosis CXCL16 CCL21 JAK3 CCL2 PMC9248407__F3 Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors TH RET SET AP2A2 DBP ABCA4 ATG14 MME PMC11052371__F3 Pathogenesis of acne and the mechanism of action of P VCAM1 FGF10 MTOR FGFR2 FGF7 CD36 PMC3173801__F1 Many receptors modulate Wnt signalling PTK7 RYK PMC9112182__F7 RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial–Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma MMP2 MMP9 RBM3 HEL113 STAT3 PMC3726314__F6 Toll-Like Receptor 4-Myeloid Differentiation Factor 88 Signaling Contributes to Ventilator-induced Lung Injury in Mice TLR4 TRAF6 IRF3 MYD88 TIRAP PMC3557433__F1 Effector intercrossing network under physiological condition NDRG2 HEL-117 TG SIRT1 UCP2 BAX MAFA PMC6467343__F1 Complications and management of coagulation disorders in leukemia patients CS TFPI PLG FDPS PMC5496628__F1 mTOR is the essential signaling pathway for nutrient sensing and apoptosis protection in the B cell TSC2 TSC1 TXNIP IRS1 PMC3384424__F1 The mTOR signaling pathway PRR5 DEPTOR RHEB PMC6679057__F2 WNT pathway molecules and their involvement in chemoresistance in NB FZD1 PMC10886236__F4 Heatmap of the pathway of glycolysis, antioxidant enzymes, and ascorbate–glutathione cycle UGDH NACA PRX HEL-S-162eP PMC9206138__F2 Immunosuppressive role of indoleamine 2, 3-dioxygenase in glioblastoma: mechanism of action and immunotherapeutic strategies TH PMC5396079__F10 Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway TSC2 TSC1 ATG12 FOXO1 RHEB PMC7010219__F7 Role of DADS in leukemia cells LIMK1 ROCK1 RAC1 PMC7733924__F6 Predicted pathways might be involved in the interaction between CSFV p7 and host cells MAPRE1 GGNBP2 POMP PIAS1 PMC11707400__F5 Immune signaling pathway of infected cells CGAS TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR8 TLR7 TLR4 ACE2 TMPRSS2 PMC6535662__F1 Various regulatory mechanisms of MALAT1 in different diabetes-related complications NLRP3 ELAVL1 MYD88 SP1 PMC1190322__F10 CdGAP mediates cross talk between the Ras/MAPK pathway and the regulation of Rac1 activity TIAM1 GRB2 SHE RAC1 PMC3573943__F1 Regulation of cellular metabolism by p53 TIGAR SCO2 PDK2 GLS2 HEL-S-20 PMC4509205__F4 PI3K/AKT network in renal cancer samples NF1 BAD MAX FOS MYC JUN BAX PMC5332432__F1 Activation and control mechanisms of the human complement system HEL-S-62p CD59 FH PMC9187795__F3 CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified TRADD TRAF5 TRAF2 TAB3 PMC5618532__F1A Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 TSC2 ULK1 BCL2 MTOR BAX PMC6359975__F2 Acquired resistance mechanisms to CDK4/6 targeting BAD BRAF CDK2 MDM2 CDK4 RPS6 PMC7349579__F2 Interactions of LCSCs influencing HCC CD47 EPCAM SMAD2 APC LRP5 SMAD4 LRP6 IL6 STAT3 CD24 PMC8146608__F4 Influenza Virus RNA Synthesis and the Innate Immune Response TBK1 IRF7 RIPK3 IRF3 TRIM25 ZBP1 MAVS MLKL PMC8394812__F1 Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages TRAF6 IRAK4 TAB3 CD36 PMC2258989__F6 Schematic presentation of the signaling pathway induced by HCV core protein for insulin resistance in human hepatocytes PI3 MTOR IRS1 PMC2840099__F7 Proposed model of miR-486 regulation and function in muscle cells GSK3B PTEN PMC8699052__F2 NRF2 in Mycobacterial Infection STAT1 CCR2 SFN PMC5076847__F12 Regulation of IRF1 and IRF1-dependent late-phase gene expression by IL1B after DUSP1 silencing and glucocorticoid treatment IL18 GC IL1B IRF-1 PMC8507617__F1 Hedgehog Signaling in Myeloid Malignancies SUFU SMO PMC10223558__F6 Identification of key hub genes ADAMTS12 GSTA4 MYC ALOX5AP CCL2 RGS14 MMP3 MGST2 GRIN1 WNT4 PCOLCE2 INPP5D COL9A2 GSTA3 CXCL14 ANGPT2 PLAUR CXCL10 TNF COL5A2 LAMA3 PLCB1 TIMP1 IGF1 THBS2 IGFBP1 CXCR4 IBSP IGFBP2 CHAD HEL113 CXCL12 MYLK IGF2R IFIT1 LMOD1 COL3A1 ACTA2 COL1A1 PDGFD COL1A2 POU5F1 PECAM1 PRKAA2 ADAMTSL1 CD34 IGF2 RPS6KA5 TSPAN33 GATA4 CXCR3 ITGAM RASGRP3 NR4A3 PLA2G3 GRB10 CALML3 WNT5B TGFBI PMC8814816__F1 Targeting cholesterol homeostasis in hematopoietic malignancies ABCG1 ABCA1 PMC10223558__F5 Networking among differentially expressed genes (DEGs) and pathways identified via GSEA B3GNT6 MYC NRARP RAPGEF4 CCL2 PDE9A GXYLT2 MMP3 B3GNT8 GSTA3 PTK6 ANGPT2 FOSL1 CXCL10 GSTM1 NRG2 COL8A1 TNF KPRP PIGR PLCB1 LPAR4 CRIP3 RASAL1 SGPP2 MUC13 ELF5 COL3A1 HEL-S-134P BAAT NKD2 EIF5 CADM1 CARNS1 ARG1 CYP17A1 RORC TNLG1B IGF2 FN3K ACSM3 HS3ST3A1 NFATC2 NR4A3 PLA2G3 WNT5B HHIP FHIT GSTA4 ALOX12 ALOX5AP ALAS2 AMPD1 SORD PYGM RGS14 GRIN1 WNT4 ACSS1 PIK3AP1 INPP5D PGLYRP1 COL9A2 GPD1 HACD1 BMP6 XPNPEP2 MGAT5B LAMA3 THBS2 CHRM1 IBSP CHAD HEL113 SAA2 MYLK PDE7B IFIT3 NMUR1 PDE5A EGFR CEACAM1 AOX1 PDGFD COL1A2 MALL PRKAA2 RPS6KA5 HS6ST2 HAO2 ACOT11 GBGT1 ALDH3B2 THEM5 CYP2S1 CHST5 TMLHE PDZD2 ITGAM CISH RASGRP3 LIPK AK8 GRB10 PMC10223558__F8 Expression analysis of genes involved in PI3-AKT-mTOR pathway post MMTV expression BAD MYC PTEN MTOR COL1A1 PDGFD TLR4 WNT4 BCR COL1A2 MDM2 CASP9 CCND1 RBL2 CD19 ANGPT2 IGF2 CDC37 RAC1 IRS1 BRCA1 RHEB TSC2 TSC1 IGF1 RASGRP3 GRB2 SYK PMC5850946__F7 Ras signaling cross-talk protein transport PML PDGFRA TRAPPC6A COG2 FGFR4 TMED10 FGF17 hCG_1998026 RPN1 FGFR2 YKT6 TSC2 KDR STX4A GRB2 SHH ETS2 VAMP7 PMC7990793__F2 Differences of inhibitory effects between homodimeric and heterodimeric IL-35 EBI3 STAT4 TYK2 JAK1 PMC6214138__F2 Canonical FLT3 and mutant FLT3 signaling pathways BAD LYN SHE FLT3 MTOR PTPA PMC4484229__F5 Serum C1 competes with Wnt for Fz receptor binding, resulting in Wnt canonical pathway activation APC LRP5 LRP6 PMC6499694__F7 Working model of how the spatial distribution of nuclear DNA damage and extracellular neurotrophic factor signaling coordinates AKT-mTORC1 activation NGF ATM RHEB PHLPP1 PMC11449287__F12 D2O on expression levels of cellular genes involved in “TNF signaling pathway” and “p53 signaling pathway” PIR MYC PTEN TNF TSC2 AIFM2 ATM MAFK CDK2 MDM2 CYC1 CDK4 BAX PMC4111749__F2 Regulation and roles of Cdc7 kinase under replication stress FANCD2 POLN RAD18 RAD51C PMC5850946__F5 PI3K-Akt signaling and Ras signaling pathways PRKCI TSC2 KDR GRB2 FGFR3 CCND1 FGFR4 PTEN HRAS HEL-S-93 FGFR2 PPP2R3A PMC7068268__F3 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer CIC PMC6468621__F3 Lung adenocarcinoma treatment and emerging therapeutic potential of targeting macrophages MARCO CCL2 CXCL12 PMC7530006__F2 Schematic Indicating Common Pattern Recognition Receptor (PRR) Pathways Used by Immune Cells to Recognize Danger Signals TBK1 CGAS TLR5 TLR9 FPR1 IRF3 RAC1 MYD88 TLR1 TLR3 NLRP3 TLR8 TLR7 TLR4 SAP130 SYK AIM2 IL1B MAVS PMC5438623__F7 Screening effective differential expression genes for hepatic carcinoma with metastasis in the peripheral blood mononuclear cells by RNA-seq MMP9 JUN IL1B PMC4773219__F6 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy TH MOB2 EEFSEC TES MMACHC RALA CSMD3 ZNF362 UBC METTL1 MTR CTNS SPTBN2 SUMF2 CST4 PARS2 MAP7D1 DKFZp686D2168 MUTYH PMC4773219__F4 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy UBC MAML2 PMC9247483__F2 Current Understanding and Management of Plasma Cell Mastitis: Can We Benefit from What We Know? SOCS2 GHR TNF MTOR PRL STAT3 PMC9000380__F1 Ferroptosis: A New Road towards Cancer Management GPX4 LPCAT3 FACL4 HEL-75 PMC545204__F3 Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia RARA PML COX1 FLT3 PMC9063252__F8 Effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy AAK1 HDAC2 ACE2 PMC11046879__F2 Illustrates the functions of PTEN in the cytoplasm and nucleus MCM2 RPA1 CENPC RAD51 PTEN MTOR MVP PMC8188603__F7 Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy PC HEL-S-11 APP TNF PMC3507431__F2 Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy SRC PTEN MTOR SIRT1 PMC7273913__F1 Characterization of FANCL variants observed in patient cancer cells FANCD2 UBE2T FANCL PMC7527441__F1 Major immune response pathways after helminth infection AREG MUC5AC IL33 IL25 TSLP ARG1 ELL PMC8405290__F5 Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking CCNA2 PPP3CA MYC DUOX2 BCL2L1 CCL2 RB1 POR SLPI DRD4 PYGM MTTP MMP3 PRKCA MMP2 MDM2 CASP9 CHRM2 HK2 UGT1A1 CXCL11 MMP10 ADRB1 FOS CXCL10 GSTM1 VEGFA TNF HAS2 CHRNA2 HMGCR HEL-S-22 ABAT CDK2 CHRM1 NR1C2 HEL-75 F7 BCL2 RORA NCF1 CHUK BAD MPO MAP2 RUNX2 COL3A1 ACACA BACE2 EGFR ACHE HSF1 COL1A1 CYP1A2 CHEK2 IL18 AHR opn F3 CCNB1 LDLR APP CCND1 CDK4 CYP1A1 ABCG2 JUN SELE FASN BAX PLB1 MMP9 PTGS2 IGF2 PTGES CXCL2 NR3C2 HEL-S-130P NR1C1 PSD IKBKB HEL-S-102 CYP3A4 RELA PPARG STAT3 PMC7990793__F4 Potential working model of IL-35 immunepathogenesis in chronic HBV infection EBI3 STAT4 TYK2 JAK1 PMC1236700__F2 Regulation of the extrinsic pathway by Hsps BAD TRADD TRAF1 BCL2 CDC37 BMF TNF TRAF2 FADD BAX PMC5353654__F7 Series of functions (e.g FGA TRH PMC5260050__F2 Pathway map for selected proteins encoded by genes that were upregulated in baseline systemic juvenile idiopathic arthritis (SJIA) samples STAT1 IRAK1 TRAF6 MYD88 JUN IRF-1 PMC5593568__F7 IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NFKB pathway and reduction of JNK in HNSCC CXCR1 NOD1 IL8RB PMC9394511__F9 Schematic model illustrating the PI3K/AKT pathway associated with CCRL25/CCR9-induced malignant biological behavior in SACC CCND1 BCL2 CCL25 BAX PMC5908625__F2 Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis BLM PTBP1 CENPE EPHB4 EPHB6 PRPF6 SF3A1 UBE2C PCF11 PAPOLA ARPC2 WASL PFN2 CPSF1 WIPF2 TYMS ITSN1 GTF2F2 EFNB3 WDR82 ACTR2 PMC11648720__F8 Schematic diagram shows that two residues change in SARS-CoV-2 N protein trigger NFKB inhibition RIPK1 TRADD TRAF5 IRAK1 TRAF6 IRAK4 MYD88 TRAF2 MAVS TMPRSS2 TAB3 PMC3120937__F1 Signalling pathways in oesophageal adenocarcinoma APC EGFR LRP5 LRP6 MTOR PMC4969253__F1 Retinoid regulation of early lung development ACTA2 FGF10 DKK1 PMC8618769__F2 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases BACE1 ABCG8 ABCG5 ABCG1 NPC1L1 ABCA1 PMC6562528__F7 PyCyp protein effects on EGFR signaling in IEC-6 cells CDK2 EGFR GRB2 PMC8618769__F5 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases BACE1 APP ACHE BCHE PMC7952444__F4 Aberrant expression of PIWIL1 mediates tumorigenesis and progression PIWIL1 BMI1 PTEN CDH2 MTOR PMC4763541__F7 Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation PC PTCH1 SHH SMO PMC6563508__F5 Cytosolic recognition of foreign nucleic acids and activation of interferon stimulated genes (ISGs) TBK1 STAT1 ISG15 STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 IFNAR1 MAVS PMC6357196__F5 Proposed chemoresistance mechanism mediated by RAB7A CD9 CDS1 CD63 RAB7A CD81 PMC6325590__F6 Leptin signaling modulates appetite through primary cilia POMC AgRP MC4R LEPR ADCY3 STAT3 PMC3929886__F8 Model for JMJD2B silencing on tumour suppression through DNA damage ATM ATR STAT3 PMC6325590__F8 Mechanisms underlying the loss of primary cilia frequently observed in cancer cells with aberrant RTK USP43 PMC11942745__F3 Putative schematic representation of the mTOR signaling pathway in APS TSC2 TSC1 DEPTOR RHEB MLST8 PMC8809118__F7 NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria LEF1 TCF3 KEAP1 ATF4 NOX4 ATF3 SIRT1 TCF4 PMC12093350__F1 P2X7R in Retinal Diseases: A Review NLRP3 CD40 GSDMD PMC5023632__F9 Possible mechanism for cross talk between P2X7 nucleotide receptor and canonical Wnt signaling pathways in cells of the osteoblast lineage WNT3A GSK3B PMC8834850__F2 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma STAT1 ATF2 STAT3 BAX PMC6268005__F2 ERAD regulation of cholesterol metabolism UBE2G2 UBIAD1 VCP HMGCR PMC8834850__F3 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma STAT1 RARA MAX ATF2 MYC ATF1 HMGN1 PMC3404840__F1 HIV pathogenesis and T-cell signaling by HIV-1 Nef CCR5 TRADD CXCR4 TRAF1 TRAF2 FADD PMC3404840__F2 Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef APC LCK CD40 PMC8895153__F3 SUMOylation in Viral Replication and Antiviral Defense TBK1 TRIM38 IRF7 SENP1 IRF3 TRIM28 SENP2 TOPORS MAVS PMC8687743__F2 HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer VCP ATAT1 HSF1 PMC8895153__F4 SUMOylation in Viral Replication and Antiviral Defense TBK1 SUMO3 CGAS TRIM38 SENP7 IRF3 SENP2 SUMO1 PMC4614078__F9 Updated model showing the role of AMPK-HDAC5 in HIF-1 activation as a response to hypoxia VHL HDAC5 IPP PMC6073502__F4A Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia SUMO3 NUMB GDA SERP1 RPSA HEL-S-32 STOML2 HEL-S-5 MDH2 HEL-S-2a RARA GDI2 ACAT1 HEL20 hEMMPRIN PPP2R2A RPLP0 SNCA ALDOB SLC34A1 FBP1 ENO1 MGST3 RSF1 ST13 HEL-S-102 RAB1A TUBA1A HEL-S-165mP HEL-S-269 CYC1 HEL-S-100n GNAS ACTR3 MEP1A STAT3 PMC2964899__F1 Schematic representation of the molecular events associated with cellular processing, lipid modification, and secretion of the SHH protein and the autocrine and paracrine actions of mature and secreted SHH protein PTCH1 SHH SMO PMC5761609__F3 Activation signals of inflammasomes NLRP3 TLR4 IL1B PMC2964899__F3 Molecular events associated with the repressive effect induced by PTCH1 receptor on the SMO activity and the activation of the Hh signaling pathway mediated by the SHH protein in the primary cilium SHH SMO PMC5646344__F1 Domain structure of Sina/Siah and its regulation in Drosophila and mammals HIPK2 ATM TWIST1 SP1 SIAH2 ETS2 ATR DYRK2 PMC2964899__F5 Cellular events and signaling elements involved in the regulation of SHH expression, GLI activation, and mediation of the Hh activation-induced cellular response EGF IL1A PDGFRA EGFR SHH RORA PMC8226934__F2 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling TSG101 FGFR3 CBL PMC2964899__F6 Scheme showing the signaling elements and frequent deregulations in the Hh signaling network and potential cross-talk with the EGFR signaling pathway involved in the malignant behavior of cancer cells HHIP HP SHH SMO PMC7360675__F1 Extracellular and intracellular regulatory mechanisms of HLA-G expression HLA-G IRF-1 CSF2RA PMC8226934__F1 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling GRB14 PTPRG FRS2 GRB2 MTOR TF PMC8904974__F8 Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition NRAS GRB2 HRAS PMC10036181__F4 Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease FGF23 SOST LCN2 DKK1 PMC10888037__F8 Schematic diagram showing the potential pathways which were more active in non-mucilage BS RFC2 MCM5 MCM6 CS MCM2 FES DLD OGDH SDHA RFC3 PMC5694782__F1 Critical DDR Pathways for UV induced DNA Damage: (1) UV induces an intrastrand lesion, causing the replication fork to stall in S-pase POLE ATM TOPBP1 BRCA2 ATRIP RAD51 POLN ATR BRCA1 PCNA PMC7937872__F7 Proposed resisting the excitability toxicity signaling pathways triggered by ICT in ischemic neurons EGF EGFR SRC GPER PMC6036739__F7 The positive feedback of CCL2 and SQSTM1 contributes to chemoresistance CCR2 SQSTM1 CCL2 MTOR PMC5393948__F6 Isl1 conditional mutants are deficient in Foxo signaling FOXO3A BACH2 FOXO6 FOXO1 ISL1 PMC2601639__F1 Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain PTEN PMC10743075__F9 N-3-PUFAs decreased mRNA expression of key enzymes of fatty acid biosynthetic pathway HEXA FH FES FASN PMC6550088__F2 Focal adhesion pathway (A) and HIF-1 signaling pathway (B) altered in a CRC TH VASP BAD HEL-S-28 FLNA ENO1 SHE DOCK1 PTEN RPS8 HEL-S-68p HEL-S-162eP LAMB1 RAP1A MYL12A MAFK ZYX ITGA6 HEL114 HEL-S-133P CDC42 PMC8047536__F3 Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B SOCS2 PRMT1 SOCS3 ISG20 LTBR IFI16 CP PMC8450407__F3 TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease TLR9 STAT2 IRF7 IRF8 IRF9 TRIM21 IRF3 STAT1 TYK2 JAK1 IRF-1 IRF4 IRF2 PMC2427336__F9 A schematic summarizing ER stress response pathways in cells compensating for deficiency of the ER stress response kinase, PERK ATF4 XBP1 PMC5355696__F3 Signaling pathway networks RICTOR NFATC2 MAPK12 KDR NFATC1 SRC PXN RHEB PMC7527241__F7 Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery MUC17 FBN2 HERC2 CORIN DNAAF2 CSMD2 TTN SYNE1 KIF13B CUBN VWF FBN3 XB NOTCH2 CACNA2D2 RELN DPYD DNAJC5 ANKRD17 MUC5B MUC2 NUP153 SCUBE1 HSPG2 BAT2L SPG11 INHBB THSD7B MALRD1 PMC5223280__F5 Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptotic Pathway During Chemotherapy in Bone Marrow CDK2 CDK4 PMC5688152__F7 Schematic overview of metabolic pathways of P CS ABAT DIO1 ACD GLA PMC10513393__F5 Cytokine-mediated signaling in T-cell lymphoma metabolic reprogramming IL21R MTOR IL23R PMC7827558__F1 Schema of the new arm of the DNA damage signaling pathway (DDR) CDYL RPL26 SRSF7 SIRT1 BCL6 PMC8798197__F5 Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells TSC2 BAD TSC1 EGFR RHEB PMC7830477__F7 Proposed mechanisms of the antioxidative actions of Pistacia lentiscus var GPX1 HEL-75 HEL-S-44 HMOX1 HEL-S-22 PMC4797633__F1 Complement system CD59 C4A CR1 PMC8861859__F7 Wheat oligopeptides enhance the intestinal mucosal barrier and alleviate inflammation via the TLR4/Myd88/MAPK signaling pathway in aged mice TLR4 MYD88 IL1B PMC3603280__F1 SLC41 family of MgtE-like magnesium transporters PLCG1 SLC41A1 MAGT1 SLC41A2 MGA TRPM7 PMC9755961__F3 Heterogeneity of neutrophils in cancer: one size does not fit all SIRPA CD47 HGF TRPM2 ARG1 PMC11967956__F7 Summary scheme of the obtained data VEGFA MTOR PMC6058924__F6 Pathway Studio Analysis of Proteomic Content of TFMPs at 6 Months in the Infarcted Groups Compared With Control Group Profile(A) Heat shock proteins (HSPs) associated with post-ischemic conditioning detected in CRT+BB–treated animals only ATP1A1 PMC12006078__F6 Potential mechanisms of acacetin in preventing DCM and drug-induced cardiotoxicity DGAT2 SIRT1 BAX PMC7343503__F6 Resveratrol regulating MARCH1 expression BCL2 PTEN STAT3 PMC3943763__F1 Toll-like receptors in antiviral innate immunity TBK1 TANK TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 MAL PMC12006078__F4 Mechanisms of action by which acacetin prevents cardiac fibrosis and hypertrophy SMAD4 MTOR NR1C1 SIRT1 PMC8580935__F1 Palbociclib as an early-line treatment for Japanese patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer: a review of clinical trial and real-world data SPOP MTOR PMC5572374__F2 Prior knowledge network (PKN) derived from public resources, including interactions connecting nodes which are measured (in blue) or perturbed (stimulated in green and inhibited in red) in the experimental data EGF IGF1R IGF1 EGFR MYC IL6 RPS6 MTOR STAT3 PMC9684205__F1 Emerging roles of fibroblast growth factor 21 in critical disease FGF21 FRS2 GRB2 PMC12006078__F3 Major signaling pathways of acacetin in protecting against endothelial injury and improving atherosclerosis ARG2 SIRT1 SIRT3 PMC4094296__F3 Pathogenetic Importance and Therapeutic Implications of NFKB in Lymphoid Malignancies BTK CARD11 BCL10 BCR IRAK1 SYK IRAK4 MYD88 JAK1 MTOR STAT3 PMC4560668__F1 WNT signaling in adult ovarian folliculogenesis APC CTCF PMC4560668__F2 WNT signaling in adult ovarian folliculogenesis APC AXIN2 PMC10312928__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide MYB EIF4A1 BAZ1B HAMP CAP1 PLEC HEL-S-87p LMNA DDB1 KMT2C RANBP1 USP14 ANXA2 HEL113 RPS27 DDX5 ABCE1 ACTN4 PMC3163125__F1 Complement system: the classical complement pathway involves a sequentially acting multistep cascade in which the complement components C1q, C1s, C1r, C4, C2, and C3 play important roles C9 C4B_2 C7 C6 PMC11529338__F5 Bone microenvironment of prostate cancer with bone metastasis PTH1R METTL3 TGFBR2 RBM3 CSF2 PMC12249962__F2 Key metabolic pathways, transcriptomic modulation, and chemotherapeutic and metabolic compounds for prostate cancer treatment HIF1A TF PMC12249962__F3 Multi-target promising compounds for prostate cancer (PCa) treatment ACSL1 ACLY HEL-S-133P HK2 FASN PMC9318110__F1 New Insights into TRP Ion Channels in Stem Cells TRPC1 FGFR1 TRPC5 TRPC6 TRPC3 OTX2 PMC9318110__F2 New Insights into TRP Ion Channels in Stem Cells NFATC1 HEL-S-11 TRPM2 SP5 SMAD1 TRPM7 STAT3 PMC12170767__F4 Process Diagram CS BPIFB4 PMC8197496__F2A Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma ATM BLM BRCA2 ATRIP BARD1 ATF1 RAD50 ATR MRE11A IFNG PMC2773962__F6 Model of Tbx2 function for the EC formation in the AVC BMPR1A BMP2 TBX2 HAS2 BMP4 PMC10222578__F5 Networks of interactions between the genes affected by the production of sfRNA in ZIKV infection of human brain organoids NGF CHAF1B TMX1 TASOR MRGPRD PAX7 BSND PCDHA2 SLC16A11 CRYGC PERP MBD4 TNFRSF10D MCM10 JUNB OSR1 ADGRA1 BAG3 ADAMTS20 DLG2 VEGFA MYDGF APOB H1-1 POU4F1 CDKN1A EGR2 SESN2 HIST1H2BE CXCL1 ACVRL1 EBP TMOD2 CA11 RAB43 CCND3 CCND2 RARB HTATIP2 F3 CDK4 GAL MDK HEL-S-87p PARP3 LEF1 COPS6 HP SLC4A10 PRMT6 MCL1 PMC1480599__F7 Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response STAT2 IRF7 IRF9 IRF3 IFNGR2 TYK2 JAK1 IFNGR1 IFNG PMC10222578__F6 Interconnection between sfRNA-affected biological processes in ZIKV-infected human brain organoids MED4 DLG2 DPF3 FAIM MRGPRD PAX7 CA11 PTEN RAB43 SCRG1 PPBP MYDGF PARP3 CCND2 STAB1 USP16 HTATIP2 EGR2 F3 CCND1 SMO EPHA2 WLS PMC4086339__F5 Deregulated focal adhesion pathway in NSCLC cell lines VASP FLNA MYL12B ARHA MAPK1 HEL114 FLNB ACTN4 PS1TP5BP1 CRKL PMC11529338__F3 Osteoclast-mediated bone resorption reactivates dormant tumor cells TBK1 BMP1 DKK3 LIF CXCR4 BMP7 ROR2 CXCL12 CDH2 MTOR PMC9439914__F2 Biological Mechanism on SIRT1/NLRP3/IL-18 Signaling Pathway of Acupuncture for Treatment of Ischemic Stroke with Center Poststroke Pain HAL DEK ARX PMC10531003__F2 Pathway from Acute Kidney Injury to Chronic Kidney Disease: Molecules Involved in Renal Fibrosis PLG TRPC6 PMC9699238__F8 Fascaplysin Induces Apoptosis and Ferroptosis, and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression GPX4 SLC7A11 ATF4 BCL2 BAX PMC3538603__F8 Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation TH LPA FYN GHR LEPR DCC GNRHR PRLHR FES ARHA ROBO2 HRAS SCTR LTB4R TACR2 PRL RHOD LEP TSHR NRP1 OXTR PRLR ROBO1 RND1 CDC42 PMC4941544__F2 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data CASP3 BAD SMAD2 APC TGFBR1 MSH6 CASP9 SMAD4 RHO DCC JUN BAX PMC4941544__F3 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data EGF BAD BRCA2 TGFBR1 SMAD4 RALBP1 STAT3 PMC8400927__F10 Cell communication analysis results for integrated choroid plexus and brain parenchyma cell types SST SV2C NRGN VIP PMC8834222__F1 Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile DGAT2 ACACA ADFP PLIN4 GPAM NFATC2 SCD ACACB PCYT2 ELOVL2 CERK IL1B FASN PMC7892499__F2 Strategies for antagonizing NLRP3 pathway myocarditis-related key inflammatory components NLRP3 S100A8 S100A9 NOD2 PMC6074871__F1 Synopsis of intratumoral cholesterol metabolism SQLE PCSK9 SCARB1 LDLR SREBF2 SOAT1 ABCA1 CYP17A1 HMGCR PMC5834268__F3 Identification of prefrontal cortex protein alterations in Alzheimer’s disease CALCA MAPK8 MICB IL34 CD6 FTH1 FTL MBL2 LAG3 AMBP SSTR2 SERPINA4 DDIT3 FGFR2 BTK ZAP70 APP EPHA1 KRT4 FURIN CD36 PMC2673422__F6 Hypoxia-invoked response of the glycolysis gene network ALDOB FBP2 ACYP1 FBP1 ENO1 GCK PFKL PFKM HEL-S-87p ACYP2 HEL-S-68p HEL-S-162eP HEL-S-49 PKLR ENO2 PFKP PGAM1 PGAM2 HK2 PMC7330112__F5 Resistance-associated BTK (C481) mutation and possibilities of its overcoming in ibrutinib-treated CLL patients BTK BCR BASH LYN BCL2 SYK PLCG2 MTOR CD19 PMC6205057__F8 The Potential Schematic Diagram of the Effects of CPE on the Beta Cell and Liver Tissue MLXIPL TG IL1B NR1C1 PMC10474200__F4 Interconnectivity between prioritized high confidence transcription factors STAT2 PGR LIF IRF3 TNF PRL RHOU MFN2 CXCR4 RELA STAT4 BIRC3 DLK2 IGFBP2 EZH2 RPS3 AXL PHF19 ADM IRF-1 CTSW ARHGDIB PSME2 PMC10474200__F5 Prolactin signaling pathway GHB3 EBP SHE TEC MAP2K2 ARHA RHO RAC1 HRAS STAT1 NEK3 GRB2 NMI SOCS1 PMC5179551__F1 Insulin signaling pathway: intracellular insulin signaling is initiated by insulin receptor tyrosine kinase activity leading to the activation of both the PI3K-Akt pathway and the MAPK pathway BAD GSK3B GRB2 PMC9111174__F8 Transcriptome Analyses of Chicken Primary Macrophages Infected With Attenuated Salmonella Typhimurium Mutants IL10 IGF2BP1 IL18 TLR7 NOD1 IRF7 IRF3 IL6 MYD88 TLR1 IL1B TLR3 PMC8277916__F4 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies GSK3B IL6 IL1B PMC9128211__F1 Biology of YAP in programmed cell death TIAM1 NLK OTUB2 RUNX3 MYC SRC TRPS1 PMC8277916__F5 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies MAF KEAP1 TNF MEF2D PMC10572622__F3 Representation of part of phenylpropanoids and oleuropein biosynthetic pathway in olive fruits DES TNLG7C PMC10865529__F5 Phenolic metabolic pathways and associated network diagrams CCR5 CCR2 CCR4 CAD CCR8 PMC6294171__F2 Canonical and non-canonical inflammasome signaling pathways.Notes: The figure describes both the canonical and non-canonical signaling pathways involved in the activation of different inflammasome components including NLRP1, NLRP3, NLRC4, and AIM2 NLRP3 NLRC4 NLRP1 AIM2 IL1B GSDMD PMC7460640__F3 Sex-related signaling pathways in aortic valve fibro-calcification STAT1 HEL-S-62p MGP RUNX2 BMP2 SMAD2 PMC3665348__F8 Summary of differential metabolism of procainamide in humans and mice CYP1A1 PMC7330112__F1 B-cell receptor (BCR) signaling pathway and BCR inhibitors BTK BCR BASH LYN BCL2 SYK PLCG2 MTOR CD19 PMC4491511__F1 In response to diverse biological stressors, macrophage migration inhibitory factor (MIF) is secreted from preformed intracytoplasmic pools CD44 CD74 PMC8450361__F1 Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management IGF1 MTOR SIRT1 PMC9581181__F2 Ion channels as a therapeutic target for renal fibrosis NLRP3 SMAD2 TRPC6 MTOR ORAI1 TRPM7 TRPV1 PMC2432084__F9 p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells CDK2 GSK3B SKP2 PMC3083340__F3 Top network affected by MAA BAD IGF1R FOS CD82 HEL-S-34 BCL2L1 RB1 ITGB1 LAMA3 CASP3 ITGA6 TNFSF10 LYN IQGAP1 CASP9 CDH2 CASP8 STAT3 PMC6008335__F1 Synthetic biology-inspired genetic circuits for caffeine-induced gene expression IL13RA1 STAT3 PMC4608393__F1 Schematic view of the LPS-mediated NFKB pathway TRAF6 MYD88 TIRAP PMC4990292__F1 Colorectal tumorigenesis in proximal/whole-colon and distal serrated polyposis BRAF HP APC PMC3731936__F5 Sequestration-induced loss of protein C receptors links coagulation, inflammation, and endothelial permeability PC APC MMP9 VWF IL6 TNF TF PMC6038710__F3 Hypothetical model for the role of lncRNAs in rheumatoid diseases CASP3 CGAS CXCL10 STAT4 CASP9 CXCL9 IRF3 IL-21 CST1 STAT3 PMC11922731__F8 This graphic illustrating the role of the CXCL2/CXCR2/Jun signaling pathway in microglia-neuron crosstalk in SAE PTGS2 IL8RB CXCL2 TFRC JUN PMC3983570__F3 Tau Acts as a Mediator for Alzheimer's Disease-Related Synaptic Deficits BACE1 FYN GSK3B CDK5 PMC3787041__F5 Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques CCR5 HGF CCR3 ADFP RARRES2 CHD2 NBR1 HLA-A IL26 CCL14 IFNK RNASE2 CXCL9 TFAM CCL3 PMC3176897__F1 Summary of fatty acid and glucose metabolism LPL CD36 HEL-S-5 PMC1456973__F6 Aspartate and aspartate transport in the pathway of prostate citrate production CS CIT MAL PMC8262608__F1 Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19 TLR8 TLR5 TLR7 TLR4 IL33 TRAF6 IRAK4 MYD88 TLR1 PMC8220219__F1 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer LATS1 LATS2 PMC9138541__F9 CAST as a Potential Oncogene, Identified by Machine Search, in Gastric Cancer Infiltrated with Macrophages and Associated with Lgr5 CAST WNT1 GPR49 FZD1 FZD5 LZIC FZD9 WNT3 WNT3A FZD7 SFRP1 WNT2B FZD8 PMC8220219__F2 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer APC GSK3B LRP5 LRP6 DKK1 EZH2 TCF4 PMC4103865__F2 Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming BAD FOS EEF2 INSR PMC8220219__F3 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer KIF26A ANGPTL4 WDR5 EZH2 FUS PMC7512049__F8 Key network of “drug-component-target-biological process- signaling pathway” (P < 0.05) CASP3 MPO F2 EGFR FPR2 BCL2L1 BDKRB2 STAT3 PMC8220219__F4 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer SMAD2 ATF3 MTA2 PMC4248707__F2 mRNA decay pathways in the cytoplasm PAN2 DCP2 XRN1 PMC11897526__F1 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway TYK2 PMC11897526__F2 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway STAT4 TYK2 STAT3 PMC11868397__F7 Pattern of USP35 negatively regulates the MAVS signaling pathway to attenuate type I interferon production TBK1 IRF3 USP35 MAVS PMC6188467__F1 RNA-seq analysis revealed that LECs exhibit a highly perturbed cytokine–cytokine receptor pathway at 24 hours PCS GHB2 IL9 FLT4 CXCL3 TPO PI3 KDR AMH IL20RA LEPR IL4 BMP2 IL20RB LTB TNF TNLG7C PRL EDAR LEP LTA IFNK PRLR IL6ST IL-21 FLT3 MPL INHBB INHBE PMC7653775__F7 An overview of homocysteine metabolism and the transsulfuration pathway CTH ChAT PEMT PMC9472369__F4 Effect of Nrf2 deletion on the proteomic signature in a human colorectal cancer cell line LOC51064 GSTA4 SLC25A10 TXNRD2 GCLC GSTM1 GPX1 HEL-S-53e GPX8 HEL-S-21 HMOX1 HEL-S-22 MGST2 GGT7 MGST1 GPX2 GSTM4 HEL-S-64p GSTM3 GGCT PMC5343002__F3 Adipose tissue pathways regulated by sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) based on current literature in mouse models, adipocyte cell lines and human studies SIRT2 NAMPT SIRT7 SIRT4 SIRT6 PARP1 SIRT1 SIRT3 PMC3461631__F2 Signaling cascades mediated by plexin-A and plexin-B, and their crosstalk with oncogenic pathways in gliomas FYN ERBB2 PTEN RAC1 PMC5343002__F2 Cellular NAD+ biosynthesis and consumption processes NAPRT NAMPT NMNAT1 NMNAT2 NMNAT3 PMC3203685__F1 Summary of the Proceedings from the 10th Annual Meeting of Molecularly Targeted Therapy in NSCLC TSC2 RICTOR EIF4E RHEB PMC3436276__F7 Model illustrates proposed two pathways of regulation of S100A4 mediated by HBXIP STAT4 PTEN S100A4 PMC4810272__F6 3Cpro from different picornaviruses suppress the immune response TBK1 IRF7 TRAF3 TRAF6 IRF3 TYK2 JAK1 KPNA1 TLR3 MAVS PMC7608146__F8 Wnt signaling and Loxl2 promote aggressive osteosarcoma ZEB2 EGFR ALOX12 WNT9A WNT7B WLS PMC10147314__F5 NAE inhibitor MLN4924 has utility in the treatment of lung cancer UBE2F MTOR MLN PMC8867675__F2 Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancers HGF EGFR MTOR STAT3 PMC10147314__F3 Several signaling pathways are closely related to NEDD8 MDM2 PPIB PTEN MTOR PMC10147314__F4 Several signaling pathways are closely related to NEDD8 UBE2M CUL7 EGFR VHL LATS1 LATS2 PMC3535349__F1 Iron homeostasis in absorptive enterocytes, macrophages, erythroblasts, and hepatocytes and its routes of circulation in the organism HEPH FES PCBP1 HFE TFR2 PMC10147314__F2 NEDD8 regulates the ubiquitin-proteasome degradation pathways related to CRL and MDM2, and it realizes the regulation of proteins by promoting the NFKB, PI3K/AKT/mTOR, Hippo-YAP and receptor tyrosine kinase signaling pathways EGFR MDM2 VHL PTEN NEDD8 MTOR PMC10854597__F8 FAK signaling in FLNC cardiomyopathy PDGFRA PHLPP1 PMC3535349__F2 Iron transport across the placenta (syncytiotrophoblasts) STEAP3 FES PCBP1 HFE TFR2 PMC2934865__F2 Hypothetical model for SUMO regulation in NFKB pathway TRADD TRAF6 MYD88 FADD PMC3501082__F7 A model to depict Tollip cooperating with Smad7 to mediate degradation of the TGFB receptor complex TBR1 PMC8312177__F1 Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease HEL-S-61p PMC8773597__F2 Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders NLRP3 KEAP1 BCL2 MTOR BAX PMC10876703__F7 TEAD1 promotes the fibroblast-to-myofibroblast transition during TAC or Ang-II-induced pathological cardiac remodelling through the Wnt signalling pathway WNT4 BRD4 PMC9312505__F12 Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation IL6 STAT3 PMC3655322__F4 Diagram showing some of the downstream elements of the proposed Hippo pathway FOXM1 CCND1 CDK4 PMC11048214__F5 IPA canonical pathway analysis in genes containing prioritised variants AIP CLPX DBT PCCB C21orf57 CDR2L APP EPHX2 HEL-S-51e PDHX GLS BAX MAL PMC10970167__F1 The protein interactome of PDE4A, B, C and D with their interconnecting protein neighbors CASP6 GSK3B OPTN DKFZp686L0365 COX2 GSC2 FYN ATOH1 MDM2 SRC ITSN1 JUN AIP DISC1 MEOX2 ZBTB1 LAMP2 FOS AKAP6 TRAF1 LYN GRB2 COIL MEOX1 PCNA PMC6035197__F2 Signaling for apoptosis and carcinogenesis pathway differentiation CASP3 CASP6 NR1i1 SMAD2 APC MYC SMAD4 IL2 MTOR DKFZp781O1323 BAX PMC3655322__F3 Diagram showing some of the upstream elements of the proposed Hippo pathway LATS1 AXL LATS2 PMC3895871__F1 TWEAK/Fn14 Signaling TRAF5 TRAF1 TRAF3 RELB TRAF2 PMC7108750__F3 Signaling pathways coordinating the hepatic regenerative response EGF RNF43 HGF DISP1 EGFR APC GSK3B LRP5 LRP6 PTEN LATS1 IL6 GPR49 MTOR LGR6 LATS2 NF2 PTCH1 SHH CCND1 SMO HEL-S-70p CDC2 ESRP2 PMC8483493__F8 Proposed the mechanism within the hypothalamic nuclei proopiomelanocortin (POMC) neurons that leptin signaling may contribute to the high sympathetic nerve activity (SNA) and increased blood pressure observed in the HFD obese rats POMC SIRT1 STAT3 PMC8570864__F5 Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology MOG FES FADD PMC5357279__F2 Intracellular trafficking path for SORLA GGA2 GGA1 PACS1 SNX27 PMC7793864__F1 Cartoon summarizes intracellular pathways used by cancer cells to support increased citrate synthesis in mitochondria PC PSAT1 ACLY HEL-S-133P PHGDH PMC3414447__F6 n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 ABL2 EDNRB A2M CRIPTO CCL17 APP TYK2 GRB10 TCF4 PMC3412960__F4 Scheme of the Rho signaling canonical pathway identified in Ingenuity Pathway Analysis of the proteins with altered expression in both KO cell lines HEL70 IGF1R RTKN EZR HEL-S-47e ARHGEF2 LPA RDX ARHGEF11 IGF1 PC EPHA1 ARHGDIB PMC8673831__F4 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes FABP2 CDKN2B LPL WFS1 TCF2 PMC12080399__F11 Mechanistic diagram illustrating the detrimental effects of TRMT10C in the nucleus under hypoxic conditions via m1A modification YTHDF2 NLRP3 TRMT10C KPNA4 TAZ CPT1A NLRX1 PMC8673831__F3 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes GSTM1 TRIB3 PTEN TNF MTOR IRS1 INSR PMC7051141__F1 New control of the senescence barrier in breast cancer RELB PAK4 CEBPB PMC7308494__F1 RIPK3 and TGFB1 NLRP3 RIPK1 TLR4 RIPK3 IL1B MLKL PMC4900219__F10 Proposed mechanism of DCLF/cytokine-induced cytotoxic synergy STAT1 TNF PMC4663793__F3 Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway RPRM CD82 MYC PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 PERP ATM APAF1 SHISA4 BBC3 CDK2 MDM2 CASP9 CCND1 ZMAT3 ATR PMC10888664__F2 Evolution of CRC BRAF APC NRAS TGFBR2 SMAD4 DCC PMC11338244__F4 Methylation of the PI3K/AKT/mTOR signaling pathway on tamoxifen TSC2 TSC1 METTL3 GDF15 ZDHHC22 PITX2 SALL2 ATF3 AK4 PTEN EZH2 RHEB PMC3516782__F5 Metabolic pathway of mannan in R RAMP1 RAMP2 PMC11338244__F2 Tamoxifen resistance TSC2 TSC1 PTEN MTOR RHEB PMC1173149__F10 TAp63Alpha-induced apoptosis APAF1 BCL2 BAX PMC5623058__F5 Lipid metabolism regulatory network proposed for the breast of female chickens at hatching, based on significant DEGs and KEGG pathway analysis SHH LEPR PPARG PMC6851151__F1 Current translational potential and underlying molecular mechanisms of necroptosis RIPK3 MLKL PMC5874051__F3 Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri ASAH2 GLB1 CERK GBA2 PMC5734045__F2 Interactions between the Wood-Ljungdahl pathway, the Embden-Meyerhof-Parnas glycolytic pathway, and the mevalonic acid pathway for the synthesis of isoprene MVD MVK HEL-S-162eP PMC6046465__F8 The “cross-talk” between purinergic receptors during the uridine triphosphate (UTP)-mediated control of Leishmania amazonensis infection LTB PANX1 PMC5983636__F1 Mammalian target of rapamycin (mTOR) signaling pathway TSC2 RICTOR ULK1 TSC1 PTEN MTOR DEPTOR RHEB PMC4994014__F1 IL-21 signaling pathway BCR PAX5 CD40 JAK3 JAK1 BCL6 PMC4994014__F2 B-cell activation and differentiation BTK MHC2TA BCR CD40 ICOS BCL6 PMC6959353__F1 Example of atom mappings of the 13C-labeling experiment used for isotopomer analysis CS PC CIT MAL PMC4994014__F3 Immunoglobulin (Ig) production BTK BCR CD40 JAK3 JAK1 ICOS BCL6 PMC9258714__F6 SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis SQLE CDK2 CCND1 PCNA PMC4994014__F5 B-cell apoptosis STAT1 JAK3 JAK1 STAT3 PMC7431799__F10 Model showing how PRRSV utilizes viral apoptotic mimicry and TIM-induced macropinocytosis as an alternative pathway to infect host cells PAK1 CD163 RAC1 CDC42 PMC10341168__F9 Ginsenoside Rh4 Improves Hepatic Lipid Metabolism and Inflammation in a Model of NAFLD by Targeting the Gut Liver Axis and Modulating the FXR Signaling Pathway CYP8B1 TG FASN PMC9139581__F5 Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors IL18 SOX3 SLC25A5 SAG ENO2 HDAC2 PFKM HIF1A SLC22A5 HEL-S-133P NR1C1 BAAT PMC7307098__F8 Working model of the innate immune response to papillomavirus infection of the female lower genital tract STAT1 CCR6 CCL20 MYD88 PMC2769196__F4 Acromegaly pathogenesis and treatment HMGA2 POU1F1 CDK4 GNAS CDK6 GHRH PMC5206990__F3 Rationale for combination therapy in lymphoma BTK BCR LYN CD40 SYK JAK1 MTOR CD79B CD79A PMC7471511__F11 Dichotomy in gene regulatory associations during the activated B-cell to plasmablast transition BCR SPIB CTCF IL2 CD40 IL-21 XBP1 IRF4 BATF PMC8065335__F5 Putative mechanisms for CVL218 as a PARP1 inhibitor to combat the COVID-19 disease, derived based on the data present in this study and the known antiviral activities of PARP1 inhibitors previously reported in the literature PARP1 IL6 TNF IL1B PMC6955653__F3 Role of lncRNAs and circRNAs in osteosarcoma ROCK1 SRA1 CREB3 PMC3112285__F2 Pathway Crosstalk TSC2 TSC1 GRB2 PTEN RHEB PMC3117038__F1 The roles of CARM1 and coactivator methylation in DNA damage signaling pathway CARM1 ATM BRCA1 BAX PMC8004207__F17 Schematic diagram showing the effect of prenatal exposure to VPA on the pathological changes in the brains of young-adult male offspring TSC2 TSC1 RHEB PMC9664406__F4 Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases GRSF1 PMC9755959__F8 MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2 SUFU PTCH1 SHH RAB31 SMO PMC4021516__F7 Wild-type p53 (WT-p53) and mutant p53 differentially regulate Nox4 expression in both TGF-Beta-dependent and independent mechanisms SMAD2 TGFBR1 NOX4 PMC3914472__F1 Metabolic pathway of the glycine cleavage enzyme system and the synthesis of its lipoate cofactor LIPT2 LIPT1 LIAS FES ISCU HSCB GLDC NFU1 APOH BOLA3 AMT GCSH PMC2689134__F4 Pathogenesis of holoprosencephaly NOG BMPR2 NODAL SMAD2 ACTR1B SMAD4 SHH SMO GAS1 SMAD1 DKFZp781O1323 FOXH1 PMC4563671__F8 Death-associated protein kinase 1 promotes growth of p53-mutant cancers TSC2 TSC1 PMC2788597__F3 Metabolic pathway of pitavastatin UGT1A3 CYP2C9 CYP3A4 UGT2B7 UGT1A1 PMC6247470__F3 Paeonol protects against atherogenesis MYD88 MTOR NR1C1 HMGCR BMP4 BAX CD36 PMC8995882__F2 Construction Immune Related Feed-Forward Loop Network Reveals Angiotensin II Receptor Blocker as Potential Neuroprotective Drug for Ischemic Stroke CCR5 CCR2 ACVRL1 CCR3 IL13RA1 TGFBR1 IL17F TGFBR2 CXCL8 IL1R2 CCL5 IL1R1 CCL2 IL17RC IL17RA IL17A IL2 IL4 IL10RA IL2RB CCL4L2 IL10 CCL8 CXCR1 IL1A CCL11 IL13RA2 IL13 IL8RB CCL4 TNF IL10RB CXCR3 CXCR4 IL2RG IL2RA CXCL12 CCL3 PMC6016866__F5 The effect of the IR on the expression of the IGF-1Ec isoform IGF1 GHR STAT3 PMC8678298__F1 Renal and Intestinal Urate Physiology SLC22A7 SLC2A9 SLC17A4 ABCG2 MAL PMC9621223__F2 Short Sleep Duration and Erectile Dysfunction: A Review of the Literature NPY GC ARHA PMC5759178__F6 Schematic model for EGFR-PI3K/AKT signaling activation induced by Notch1C1133Y mutation EGFR NOTCH1 HDC PMC10940489__F7 STAT3 influences cardiac fibrosis through multiple pathways SMAD2 SMAD4 STAT3 PMC8278519__F2 Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities LIF IL4 IFNG PMC4626583__F3 Function of bacterial actin nucleators during infection PPIG COMMD1 SHC1 TARP PMC3425429__F1 Working model depicting some of the multiple signaling pathways that have been reported to modulate cell-cycle activation and/or proliferation in rodent Beta-cells TPH1 HGF PRLR TPH2 PTEN IRS1 FOXO1 RHEB PMC4179136__F5 Perturbation of MAPK signaling pathway at 24 h after MPP+ treatment EGF CHUK BRAF FLNA ATF2 TGFBR1 MYC MAF DUSP14 PDGFA ATF4 ECSIT JUN MOS PDGFRA FOS RRAS CRK DDIT3 NLK CASP3 MAX EVI1 DAP3 JUND KEL TRAF2 DUSP3 TGFBI PMC4179136__F6 Perturbation of ER protein processing pathway at 24 h after MPP+ treatment GANAB HEL-S-99n SVIP DBT DDIT3 CRYAA CANX PLAA PREB STUB1 SEC31A GCS1 DERL2 VCP BCAP31 PMC3935308__F2 High-confidence reaction map of the TSLP signaling pathway TH FES MYC TEC TSLP NFKBIA BTK CISH NFKB2 GAB2 CRLF2 LCK STAT4 LYN SRC UNK JAK1 PMC11394960__F10 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the spleen in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC4179136__F4 Perturbation of the MAPK signaling pathway at 9 h after MPP+ treatment EGF CHUK BRAF NGF DAO FLNA EGFR TGFBR1 MYC PRKCA NF1 DUSP14 ECSIT JUN CD14 MOS FOS HEL-S-28 RRAS2 CRK NFATC3 NLK CASP3 LEP DUSP10 MAX MAEA EVI1 SOS1 BDNF PMC8011850__F8 Model depicting the pathway stimulated by TNFA to increase venous endothelial permeability TRPV4 SRC PANX1 TNF PMC3445701__F7 Alzheimer’s Disease pathway from KEGG CASP3 SNCA CASP12 BAD APAF1 GSK3B LPL CASP9 APP TNF FADD PMC4330251__F3 Wnt signaling pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG) (SFRP genes are in red box) BAMBI NLK APC SOST SMAD4 SKP1 NR1C1 FIS1 PMC6480215__F1 Regulation of osteoblast proliferation and differentiation by transcription factors IHH RUNX2 SP7 PMC6480215__F2 Calvarial bone development and suture closure IHH RUNX2 WNT1 FGFR3 DLX5 NCAM1 PTHLH COL1A1 WNT10B FGFR2 TNC PTCH1 opn IBSP PMC3334867__F5 Inborn Errors of Human JAKs and STATs CNTF STAT1 CLC SOCS3 LIF OSM SOCS1 IFNG STAT3 PMC6848778__F9 KEGG analysis of carbonylated lysosomal proteins in human end-stage PSC TEF POR PMC11974029__F1 Mechanisms through which berberine treats breast cancer involve modulation of the XRCC1 enzyme in BER FEN1 OGG1 PCNA PMC11974029__F2 Mechanisms by which capsaicin treat NSCLC involve modulation of the ERCC1 enzyme in the NER pathway XPC ERCC1 DDB2 DDB1 PCNA TRPV1 PMC2954851__F2 Protein serine/threonine phosphatases in the DNA damage response pathway RAD1 ATM ATRIP MDM2 RAD50 ATR H2AX MRE11A BRCA1 PMC4790586__F5 Signaling cascades through Twist and their roles in carcinogenesis CDH2 FOXC2 STAT3 CD24 PMC11974029__F3 Apigenin holds promise in the treatment of ischemic stroke by modulating RAD51 and BRCA1 during HRR as well as Ku70/80 in NHEJ RAD51 MTOR BRCA1 PMC5740024__F1 pH Dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs GC HEL-S-5 PMC11974029__F5 Retigeric acid B effectively treats prostate cancer by modulating the MSH2 and MSH6 enzymes involved in MMR ATM MSH6 RAD51 MSH2 BRCA1 PMC5139832__F3 Differentially expressed genes between young and aged tibiae are significantly enriched for ECM-receptor interactions, TCA cycle and cell cycle pathway components E2F4 CS ORC6 CDC25B DBF4 HEL60 CDK6 MDH2 CDC6 CDK2 SUCLG1 CDK4 CDC2 SUCLA2 OGDH DLAT SDHA MYT1 PMC11945191__F1 The host type I interferon signaling pathway by bacteria TBK1 CGAS TLR9 TRAF3 TRAF6 MYD88 NOD2 TLR3 TLR8 TLR7 TLR4 NOD1 MAVS PMC6035044__F2 Prolactin Regulation of the Prostate Gland: A Female Player in a Male Game CCND1 PRL PMC5504267__F2 Reactions involving ROS, antioxidant systems and energy metabolism GCLM GCLC HEL-S-64p HEL-75 NNT TXN PMC3504728__F7 Speculative model of macrophage alternative activation regulation by estrogen JAK1 SOCS1 PMC7670425__F3 Critical roles of FAM134B in ER-phagy and diseases TNFRSF19 PMC6060635__F1 Expanding complement therapeutics for the treatment of paroxysmal nocturnal hemoglobinuria HEL-S-62p C9 C1S PMC4681751__F1 Biological interaction network revealed by Ingenuity Pathway Analysis C4B_2 MAFF LAT2 ALB PROC ZNF365 TNF HTR4 ITIH4 PLTP TREM1 ZFP36 DUSP14 LGALS7B HBB SERPINA1 CCL27 APOA2 KRT10 APOE PMC7826375__F6 The interplay between ATRX and RECQ5 to regulate distinct subpathways of HR GEN1 BLM PCNA PMC8836457__F1 Sclerostin in Bone Diseases LRP5 LRP6 PMC7957553__F3 ROS-dependent transduction signaling KEAP1 FOS JUN PRX NQO1 PMC2656226__F6 Mitochondrial regulation of the apoptotic pathway is altered in disease and modulated by sirolimus treatment BAD DAO FOXO3A HSPD1 TNF DIABLO HTRA2 BCL2L2 NFKBIA MEN1 BTG1 BTG2 CAD BOK PMC2656226__F9 Complement pathway altered in disease CS C4B_2 C7 MASP2 CR2 C4A CR1 PMC6948348__F4 The integrated NSCLC pathway for compound Liuju formula ME1 HGF TRADD EBP MMP9 VEGFA HPSE COX2 MMP2 BCR FRS2 GRB2 IL1B CD19 PMC5553087__F1 Toll-like receptor (TLR) stimulation, signaling, and immunological outcomes TBK1 TLR4 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 TIRAP PMC3860870__F1 Apoptosis by HPV early proteins: A number of the interactions of viral oncoproteins with cellular proteins and their effects on apoptosis TNF FADD PMC8329414__F2 Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer ANXA3 TNF MTOR BAX PMC8581873__F2 Expression and crucial role of long non-coding RNA FGD5-AS1 in human cancers FGFRL1 WEE1 DDX5 PMC3854132__F1 Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy EGF BAD EGFR PTEN MCL1 VIP PMC3652637__F11 Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases EGF GC GRB2 PMC7178030__F1 Timeline of genes involved in gonadal development ZNRF3 DHH EMX2 LHX9 PBX1 WT1 SOX8 FOXL2 FGFR2 GATA4 SOX9 FGF9 SRY NR2F2 LEF1 SOX3 AMH WNT4 DHX37 PMC6139073__F1 Wingless/integrated (Wnt) signaling pathway APC FZD2 LRP5 LRP6 RHO PMC8187637__F2 Canonical stress granule assembly pathway EIF2A HNRNPA2B1 HNRNPA0 EWSR1 PMC2724271__F4 Metabolic map of HIF-target genes CD99 NPM1 KRT19 CCNG2 TAOK2 MMP2 EN1 TMEM70 PGAM1 HEL-S-133P HK2 MRPL4 ARHGEF1 P4HA2 PLAUR SLC25A28 VEGFA ENO1 ISCU GAST HEL-S-68p HEL-S-49 CXCR4 IGFBP2 HEL113 PSMD4 CP TF TERT P4HA1 TFRC RARA NPAT FECH PLD2 PDGFA NF2 FH MRPS12 CAD RBPJ ANXA1 SLC16A10 ABCF2 PTGS2 IGF2 NR3C1 GYS1 PFKL HEL-S-87p HEL-S-130P BTAF1 HEL-S-162eP BNIP3 CYCS PMC3196743__F2 The Contribution of Vitamin A to Autocrine Regulation of Fat Depots GC KLF5 CEBPA PMC1421310__F1 High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells SMAD2 SMAD1 PMC3133232__F8 Schematic model of Nrf2 regulation by Keap1 MAF KEAP1 RBX1 PMC5046039__F2 Molecular regulation of MSCs during bone formation EGF BMPR2 IHH RUNX2 CSK APC SMO PTH DLX5 PMC2824740__F5 Strain-induced quantitative mRNA-expression analysis of PDL cells related to MAP-kinase signalling and cell cycle, ECM and integrins, and growth factor pathways EREG CDKN2C FOS BMP2 FGF2 VEGFA HBEGF IL11 FGF9 VEGFC IL18 COL14A1 MMP12 PMC3484412__F2 Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway EPO MTOR PMC2990406__F8 A previously unknown miR-290–dependent pathway controls DNA methylation via Rbl2 and affects telomere integrity and telomere-length homeostasis DNMT3B RBL2 PMC7878609__F3 Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling EGF CXCR4 EGFR CXCL12 PMC11621799__F4 Pathway activation in ACO and COPD identified through KEGGpathway enrichmentanalysis PIG59 EPO USP21 TRADD VHL TFRC HEL-S-87p TNF MTOR RBX1 POR TLR3 ZBP1 HEL-S-162eP NLRP3 TLR4 CYLD IL33 H2AX HEL-S-133P FADD MLKL TF STAT3 PMC7397096__F7 Myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice CARM1 HDAC3 NCOR1 RUNX2 PGR FOXO3A CBL TLR4 PC PELP1 GRB2 CD40 DDX5 IL4 BDNF PMC2504032__F8 Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine CCNA2 CDK2 ATF4 EIF2A PMC9388649__F7 TMEM16E affecting bone metabolism through intracellular Ca2+ signal transmission NFATC1 PTH PMC7660084__F1 Summary of signaling pathways involved in the differentiation of pluripotent cells into corneal epithelial cells ZNRF3 RNF43 NODAL SMAD2 APC SMAD4 FZD7 SMAD1 TF DKFZp781O1323 PMC548501__F4 Taxotere and Furtulon on cell cycle, apoptosis, and other pathway related gene expression analyzed and visualized by GenMAPP software integrated with cDNA microarray data TGIF2 BARD1 GADD45A MAP2K6 BRCA1 CDK6 GADD45B ELF3 CDK2 SRM TEF CDC27 BCL2 CDK4 CDK9 PCNA PMC8847901__F1 Autophagy and skin wound healing ATG12 ATG3 FOXO3A ATG101 BNIP3 ATG10 MTOR ATG14 DKFZp686F0183 PMC8929358__F4 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping WAS PMC3173800__F2 Two major pathways to caspase activation in vertebrates: the death receptor or extrinsic pathway, engaged by the indicated members of the TNF receptor family on the cell surface, and the Bcl-2-regulated mitochondrial or intrinsic pathway TRADD FADD BAX PMC11908393__F8 Tenascin-C induces microglial polarization through the TLR4/MyD88/NFKB pathway TNC TLR4 MYD88 PMC6420571__F6 Beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma BCL2 PARP1 MTOR CDK7 PMC3841210__F7 FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer RUNX3 FOXO3A DIABLO FADD BAX PMC5886582__F5 Signature pathway expression of xylose utilization in the genetically engineered industrial yeast Saccharomyces cerevisiae PGM3 PGM2 PCK1 FBP1 ENO1 ADH5 ADH7 NOM1 tal-1 HEL60 HEL-S-32 HEL-S-4 MDH2 HEL-S-68p HEL-S-49 HEL-S-26 ACO2 ENO2 PMC6628492__F4 Synthesis of BDNF and potential downstream involved in the effects of botanicals and active components on depression CRH ARHA RAC1 MTOR BDNF PMC6684519__F7 Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma TRAF4 PMC4790586__F1 Signaling pathways involving the molecules reviewed TWIST1 TBX2 DHFR MYC MDM2 CCND1 YY1 CDK4 BMI1 JUNB EZH2 PMC2375563__F1 Muscle growth: no IGFs, ands, or buts TSC2 MYC EIF4E MTOR RHEB PMC4615578__F9 The mechanisms of the miR-449a tumor suppressive function in neuroblastoma cells LEF1 PKP4 MFAP4 TSEN15 CDK6 PMC5790442__F9 Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells MAF KEAP1 NQO1 PMC3153880__F3 Schematic representation of the effect of conventional treatment (Conv) and novel treatment (TKIs) on tumor behavior through the EGF-EGFR pathway EGF PC EGFR PMC6162711__F2 NFKB1 p105/p50 regulation of gene expression in cancer GADD45B CXCL1 IL16 CXCL10 TRAF1 EGFR VEGFA CXCL2 S100A9 HDAC1 PMC2176131__F7 Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–B Signaling EGF SMAD2 EGFR PMC5807852__F7 RHBDD1 promotes metastasis in colorectal cancer RHBDD1 PMC8080689__F1 Autophagy pathway ATG12 ATG3 ATG10 MTOR ATG14 DKFZp686F0183 PMC515190__F1 Cholesterol metabolism showing the physiological compartments involved ABCA1 ACD TG PMC5750119__F9 Transcripts corresponding to most genes present in the KEGG Cell Cycle Pathway were increased in abundance in CCDs from rats on Day 2 of development of vasopressin-escape MALL SMAD2 CA14 CDK7 SKP2 MAL MYT1 PMC7102569__F1 Apoptosis signaling in response to infection CGAS IRF3 TLR3 MAVS BAX PMC10380530__F1 Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management IRAK1 IRAK2 TRAF6 IRAK4 MYD88 IRAK3 GSDMD PMC1763171__F2 The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death CS PC TFPI PLG APC PMC8772974__F3 Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease CGAS TLR4 UCP2 PMC8591135__F1 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems TRAK1 TBK1 TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR8 TLR7 TLR4 TIRAP TAB3 PMC5046039__F3 Bone remodeling: (a) in precursor cell stage, the macrophage-colony stimulating factor (M-CSF) binds to its receptor (c-Fms) SPARC BTK IHH RUNX2 BASH DAP TEC TRAF6 SYK MSX2 DLX5 COL1A1 PMC8264285__F2 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment EGF BAD GSK3B PPY PTEN RHO MTOR FOXO1 GRB2 CASP9 BCL2 CR2 SP1 PMC8591135__F3 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems TLR8 TLR7 TLR4 TLR9 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 TLR3 PMC5872399__F5 The complexity of AM death Regulation following infection, trauma, and HS HMGB1 TLR4 MYD88 NOD2 PMC8264285__F3 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment PAK1 HGF GRB2 RAC1 SP1 PMC6136992__F2 Sending mixed signals: Cilia-dependent signaling during development and disease SUFU EVC2 GPR161 SHH SMO INPP5E PMC3469587__F7 SP-A-regulated signaling pathways in human macrophages TLR4 IRAK1 TRAF6 TNF PMC3962840__F5 Relationships between the cellular signal pathways in HAdV-36 infected human muscle cells CDCA4 CCDC14 ORC6 JARID2 PELI1 CENPO PTX3 MCM5 E2F7 PKP1 RNF144A WDR76 E2F2 SERINC3 MCM10 DUSP2 PMC10033690__F1 Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons PTGER2 PTGIR COX2 PTGFR PTGIS COX1 PTGES TBXA2R PTGER3 PMC9503107__F8 Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway in Hippocampal HT22 Neuronal Cells GPX1 CNP SIRT1 PMC3765447__F3 Signaling pathways involving EPCAM, proposed by Maetzel D et al EPCAM APC GSK3B FHL2 PMC8187207__F9 Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity DAG1 PC SGMS1 SGMS2 PMC3465331__F6 In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow MAX SUV39H1 ATM DHFR MDM2 SMAD4 NRG1 ATR PAK1IP1 PCNA PMC9508642__F8 Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ Beta-catenin axis with subsequent inhibition of liver cancer stem cells APC MMP9 STAT3 PMC8873584__F1 SPINKs in Tumors: Potential Therapeutic Targets SOX2 EBP STAT3 PMC8416465__F2 How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension? PC SLC3A2 MTOR PMC7510303__F4 Diseases and regulator effects networks associated with the differentially expressed peptide precursors SYNE2 PGR JAG2 AHNAK SLC4A4 IL17RC SPHK2 THRA SYNE1 SNTB2 LRP1B MUC19 BIRC6 SCN11A BAHCC1 RNF123 COL4A4 BSN KLF14 MMRN1 PIGR CROCC GRHL3 KMT2C TSC2 MTR AGO2 DUSP10 KALRN ATN1 APC2 STIM1 PMC9247709__F9 Schematic diagram illustrating how miR-21/PARP-1 activates the PI3K/AKT signaling pathway to induce EMT and migration of 16HBE cells CDH2 PMC7476571__F4 Viral miRNAs target genes involved in interferon signaling pathway STAT1 STAT2 IRF7 IRF9 RIGI IRF3 IFNGR2 IFNAR2 JAK1 IFNAR1 IFNGR1 PMC11214299__F3 Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia PML GCA ULK1 USP15 LRSAM1 MYC TRAF6 PTEN USP25 FBXW7 CBL USP9X USP47 USP6 SIAH2 DYRK2 SKP2 PMC5971008__F6 Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma RLN2 HEL-S-28 LMO1 RSU1 CPD LIMS1 PMC7238203__F1 DNA sensing mechanisms through the cGAS/STING/TBK1 signaling pathway TBK1 CGAS NLRX1 IRF3 PMC1507568__F3 The p53 response is triggered by many different stresses involving both DNA-damaging and non-DNA-damaging agents MYC PMC2359939__F9 Proposed mechanism for RES induced apoptosis in LNCaP and PC-3 human prostate tumour cells CCND1 ELL PMC7726415__F1 Major metabolism pathways by Nrf2 ME1 GCLM GPX4 GCLC FTH1 FTL HMOX1 HEL-S-26 FECH HEL-S-10 HEL107 FASN CD36 PMC8393628__F2 Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications HGF EGFR MYC TRAF6 PTEN REL MTOR UNG PSD BAX PMC2064670__F5 Model integrating calcium mobilization into the Fas signaling pathway FADD PMC2675492__F1 Biochemical schematics: This figure maybe regarded as the biochemical underpinning of our model SP1 TGFA PMC4282534__F5 Relationship of bm2 to the lignin biosynthetic pathway MTR CAD PMC4385913__F1 Cytotoxic agents impact the Bcl-2 rheostat BAD BMF BAX PMC7730528__F4 Prolidase induces EGFR-downstream signaling pathway EGFR MTOR HEL-S-162eP PMC7943879__F6 Forsythoside A (FTA) attenuates lipopolysaccharide (LPS)-induced endometritis by causing significant changes in the number of miRNAs in bESCs to regulate the target genes involved in different pathway TLR4 DHX58 CXCL5 IL27 CXCL9 CXCL8 TRAF6 IL2RA IL6ST IL6 IL-21 PMC5730419__F2 Alternative signaling pathways of GFLs RET GRB2 SHE SRC GAS1 PMC5832583__F5A Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism CS FH ACO2 MDH2 PMC9323637__F3 Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy NOTCH2 PPARGC1A HMGCS1 RHO ARF6 HMGCR RAB11B PMC3426550__F6 SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR GHB3 IRS4 PC PGP MIP TG PMC7672660__F5 Lipid mass spectrometry imaging and proteomic analysis of severe aortic stenosis FCGR1A CFHR5 IFNG DCN SMARCA4 LAP3 CFH SERPING1 THBS1 HOXD3 APOA2 KRT10 SERPINA7 OSTN HRG AEBP1 PTX3 HEL-S-69p C8A GPX3 CANX C1QB ORM2 AHSG HBB BCL2 C1QC TF PMC7601667__F2 Cross-link between EMT-induced signalling pathways and Autophagy-inducedsignalling pathways EGF ZEB2 TGFA PMC5646997__F2 Schematic representation of the effects of glutamate excitotoxicity, energy metabolism deficiency and axonopathy in ALS pathogenesis SEMA3A BDNF PMC2771939__F1 Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Signaling in Immune Cell Functions RHO LAT CDC42 PMC2039930__F7 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction MAX GSK3B MYC PMC4512107__F2 Let-7 targets insulin signaling pathway and thus inhibits cancer cell metabolism TSC2 RICTOR TSC1 EBP MYC EIF4E MTOR EIF4B HEL-S-133P RHEB PMC4479845__F6 Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis CCR5 TBP CCL4 CCL2 PMC9488681__F1 Pulmonary hypertension associated with neurofibromatosis type 1 NF1 TSC2 TSC1 MTOR RHEB PMC11619108__F3 Cnetplot of enriched pathways of DRPs identified through KEGG analysis PIK3CD MARCKS PPP3CA HSPA2 PPP2R2C GSK3B NCK1 IFNG PRKCA VAV3 FYN INPP5D B2M ARPC1B HSPA4 ACTR2 VAV1 HLA-DRB1 CRK HLA-F ARPC4 HLA-A PAK1 ARPC2 ARPC3 HEL-S-269 PPP2CA SPHK1 HLA-DRB4 HSPA1A HEL-S-72p CDC42 PRKCE NCK2 HSP90AB1 HEL-S-15 CFL2 PPP2R1A LCP2 NFYB PPP2R2D HEL-S-89n ARHA ARPC5 TAPBP HLA-DPB1 ZAP70 LYN RAF1 ARF6 ACTR3 HLA-DQA2 PMC5997832__F1 IRE1A structure and its downstream mechanisms in mild and severe stress BCL2 TXNIP RTCB XBP1 BAX PMC5997832__F2 IRE1A regulates the immune function through various mechanisms including both its kinase (A) and RNase (B) functions GSK3B IL6 RIPK2 TAPBP IL15 NLRP3 RIPK1 IL18 IL16 TLR7 TLR4 NOD1 TXNIP TRAF2 MAVS PMC7542964__F4 KEGG enrichment map of NOD-like receptor signaling pathway MYC DAP ARHA MCU PMC11619108__F2 Cnetplot of enriched pathways of DRPs identified through REACTOME analysis KAT5 CARM1 PBRM1 NCOR1 RBBP4 ARID2 CHD4 MYST4 TAF12 SMARCC1 SMARCA4 KDM2A H2AX DPY30 HCFC1 SGF29 SUPT20H H2AZ2 COPRS SMARCC2 GATAD2A CALM1 PAK1 SMARCD2 WDR5 CDC42 MYH9 TBL1XR1 TBL1X BRMS1 SETD1A MYL6 TRRAP RHO MTA2 YEATS4 CHD3 IKBKAP MBD3 KDM5C ENY2 SAP30 NCOR2 KDM1A HDAC1 MORF4L2 SMARCE1 RCOR1 ARID1B SAP130 OGT PRMT6 SMARCD1 KDM6B PMC7913190__F2 Caspase-11 upregulation occurs as a result of PAMP and/or cytokine signaling and can be amplified by complement signaling HEL-S-62p TBK1 STAT2 IRF7 IRAK1 IRF9 TRAF6 IRAK4 IRF3 IFNAR2 MYD88 TNF IFNG STAT1 NLRP3 CPB1 TYK2 JAK1 MAL PMC6153124__F1 Various published mechanisms of resistance to FMS-like tyrosine kinase 3 inhibitors PGP RAD51 FLT3 PMC7407660__F2 COP9 signalosome (CSN) partners with ubiquitin-specific protease 15 (USP15) and 48 (USP48) in the NFKB signaling pathway USP15 SKP1 RBX1 USP48 SOCS1 PMC11050207__F4 Significantly altered KEGG pathways in LAPST versus CPG group comparison BAD MEI1 TRADD FLNA PTEN RAC1 EIF4E MYD88 TNF MTOR BRCA1 RHEB TSC2 MAX GRB2 SYK SKI TRAF2 MEF2C MPL RBL2 PMC11050207__F5 Significantly altered KEGG pathways in LAPST vs NPAT RHOD VASP BAD FYN SHE VWF CHAD PTEN DMP1 CD36 PMC4628383__F1 Schematic representation of the brain microvasculature features and corresponding Impact of TS VCAM1 PECAM1 PMC7541012__F2 Roles of cancer‐associated fibroblasts (CAFs) in cancer chemoresistance IL10 HGF IGF1 LIF BCL2 LRP6 IRAK4 IL6 CHI3L1 STAT3 PMC9117765__F2 TEAD4 as an Oncogene and a Mitochondrial Modulator RUNX3 NF2 TEAD4 LATS1 RHO MTOR LATS2 PMC9117765__F3 TEAD4 as an Oncogene and a Mitochondrial Modulator RUNX3 NF2 VGLL4 TEAD4 LATS1 MTOR LATS2 TCF4 PMC9168599__F8 Activation of PI3K/p110A in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation FGF10 PTEN SOX9 ISL1 HES1 PMC8607377__F2 Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia ZEB2 STAT3 PMC6448148__F1 Biosynthesis of all known wyosine bases TYW3 TYW1 TYW5 PMC11718879__F1 Hedgehog signaling pathway PTCH1 SHH SMO PMC9632491__F1 Protein phosphorylation in cell signaling, disease, and the intervention therapy TSC2 RHOD BAD PTEN RAC1 COMP PMC9632491__F3 Protein phosphorylation in cell signaling, disease, and the intervention therapy MAX TRADD MYC BCL2 TNF MTOR ATR TRAF2 BRCA1 PMC3922035__F5 Protein interaction network analysis of the up-regulated proteins in M CALU CTSO MPC2 HEL113 FLNB CLU PNP PMC4131037__F5 ChiBE overview STAT1 PIAS1 IFNG SUMO1 PMC9632491__F8 Protein phosphorylation in cell signaling, disease, and the intervention therapy NLK KIF7 ITGB8 MYC H2AX PMC3535741__F1 PI3K/AKT/GSK3/mTOR signaling TSC2 TSC1 PTEN MTOR PMC9632491__F4 Protein phosphorylation in cell signaling, disease, and the intervention therapy E2F4 MYC ERH CDK4 MCL1 PCNA CDK6 CFTR PMC9632491__F5 Protein phosphorylation in cell signaling, disease, and the intervention therapy EGF PAK1 TRADD EGFR GRB2 TNF TRAF2 PMC9632491__F6 Protein phosphorylation in cell signaling, disease, and the intervention therapy EGF RASSF1 IRF9 EGFR LYN GRB2 UNK SRC SYK ENG FLT3 IRS1 PMC4712335__F8 Age-related neuroinflammation and changes in AKT-GSK-3B and WNT/ Beta-CATENIN signaling in rat hippocampus GSK3B DVL2 AXIN2 PMC9632491__F7 Protein phosphorylation in cell signaling, disease, and the intervention therapy HEL70 MYD88 TGFA MLKL TIRAP PMC6468845__F3 Reprogramming of lipid metabolism under hypoxia NEU3 CPT1A ADFP SIAH2 HEL-S-104 FASN PMC7359022__F2 Release of HMGB1 protein and HMGB1 signaling pathways HMGB1 TLR4 TLR9 CXCR4 MYD88 PMC4161359__F1 Mechanisms of AR pathway activation in CRPC PMC4161359__F2 Feedback pathways of AR, PTEN, and PI3K EGR1 FKBP5 EZH2 MTOR JUN PMC3789182__F7 Schematic illustrating a model of NA anticancer activity is proposed TSC2 EGF TSC1 IL6 TNF HK2 PMC7359022__F4 Dual role of HMGB1 in chemoresistance HMGB1 PINK1 TLR4 SIRT6 MYD88 MTOR PMC8269070__F4 Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels? STAT1 GRIP1 STAT2 IRF3 TF PMC3860334__F7 Different vesicle transport pathways and the functions of Rab GTPases identified from the hUCBMSC MVs RAB15 RAB35 RAB14 RAB37 RAB31 RAB32 PMC5761799__F8 Metabolic map of phenolic and glucosinolate metabolism in the primary inflorescence stems of the wild type, ccr1-6, and ccr1-6 ProSNBE:CCR1 lines CAD ACD PMC3431883__F3 Signaling mechanisms of oligodendrocyte injury STAT1 FADD PMC7523401__F8 Target-Pathway network for HQ-BS anti-IBD EGFR CXCL8 CCL2 MTOR HMOX1 INSR IFNG STAT1 PRKCA IL18 TLR4 IL17A CASP9 CCND1 JUN IL1B SELE IL10 IL13 FOS PTGS2 MMP9 CXCL10 VEGFA IL6 TNF CASP3 IGF1 VCAM1 RELA PPARG TGFB1 STAT3 PMC5896143__F1 Violacein biosynthetic pathway (a) and plasmid maps of the complete (b) and partial (c, d and e) operons for violacein biosynthesis ME1 BAD NOA1 TG NDE1 MAL PMC7523401__F7 Distribution of partial targets of HQ-BS on the IBD pathway IL10 APC IL2 IL-21 IL23R PMC6056925__F5 B cell receptor signaling pathway and network of anti-inflammation PLCG1 CCR5 MMP9 SOST CDK5 RRAD HRAS CD79B CD79A BTK MAP2K1 BCL10 BCR INPP5D CD22 LYN PTPN11 SRC PTPN6 YWHAG HEL-S-72p AK1 VAV2 CD19 PMC5576859__F7 Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation AGO1 CHP1 ARC PMC9539803__F1 Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19 EGF CXCL1 CXCL10 CXCL8 CXCL2 CCL7 IL6 CCL2 IL33 JAK1 ACE2 IL1B TMPRSS2 PMC3077220__F1 Hepatitis C Virus NS2 Protein Triggers Endoplasmic Reticulum Stress and Suppresses its Own Viral Replication EIF2A XBP1 PMC7962658__F6 Effects of Cryptotanshinone (Cts) on the Akt-GSK-3Beta-mPTP signaling pathway CASP3 GSK3B PMC7030939__F7 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity VPS35 PML VPS25 EHD2 F3 LDLR ARHA AMPH OTP CAPZB PMC7030939__F8 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity CD14 TLR4 MPO TUBB M6PR VAMP3 SRA1 HEL-S-99n RILP CD36 PMC8699276__F1 Targeting KRAS in NSCLC: Old Failures and New Options for “Non-G12c” Patients TIAM1 PAK1 GRB2 PTEN RAC1 RLBP1 MTOR PMC5872597__F5 Celtis choseniana eethanol extract-mediated anti-inflammatory activity COX2 IL16 TLR4 SRC IL6 MYD88 IL1B TLR3 PMC6050907__F4 Neurotrophic signaling cascades EGF NGF PDGFRA GRB2 GDNF ARHA RAC1 MTOR BDNF CRK PMC5988709__F1 NNMT links NAD+ and methionine metabolism HEL-S-61p NAMPT HEL-S-182mP NNMT HEL-S-20 PEMT PMC8351122__F2 Fibroblast Growth Factor 19 in Hepatocellular Carcinoma RIT1 SMAD2 NTRK1 EGFR FGFR4 DIRAS3 EIF4E UBB CRK SHC3 THRSP TSC2 PDLIM2 NGFR FRS2 PTPN1 PTPN11 GRB2 FGF19 SHC1 STAT3 PMC4694848__F7 Thioredoxin 1 mediates TGF-Beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma GSK3B CDH2 TXN PMC4116528__F9 Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3B signaling pathway in non-small-cell lung cancer GSK3B SMAD1 PMC5341249__F2 Assays for the identification of G protein signalling pathways using the constitutive activity of an orphan GPCR FAR1 ARHA PMC3432651__F2 Involvement of the target of rapamycin (mTOR) pathway in human disease syndromes NF1 NF2 VHL PTEN RHEB PMC6954967__F8 Genes within the cGMP-PKG-Ca2+ signaling pathway altered via alternative splicing in the myocardium of DM and ChD mice HDAC7 ARHGEF10 CACNA1C MEF2D PMC7611834__F3 T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives RORC SMAD2 TGFBR2 SMAD4 STAT3 FOXP3 PMC8204251__F1 Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy? MTOR IFNAR1 IL6R MLKL PMC6406365__F1 A simplified model for canonical HhP SUFU PTCH1 SMO PMC9691967__F3 Tailoring biomaterials and applications targeting tumor-associated macrophages in cancers MHC2TA BCR MARCO NPS F3 CD40 PMC12100877__F2 Emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome NLRP3 GC WTAP IL1B GATA3 PMC4669099__F3 Targeting BCR signaling attenuates homing, survival, EMDR and MRD of malignant B cells BTK BCR BASH LYN SYK CD79B CD79A PMC9396390__F2 Targeting tumor microenvironment for cholangiocarcinoma: Opportunities for precision medicine CXCL9 CCL2 PMC2927952__F3 Insulin signaling pathway from PathVisio PRKCI PRKCZ PRKAA2 ACACA FBP1 INS PRKAA1 IRS1 INSR ACACB PCK2 PRKAG1 PFKP FASN PMC5659938__F11 MiR-21-mediated suppression of Smad7 induces TGFB1 and can be inhibited by activation of Nrf2 in alcohol-treated lung fibroblasts TGFB1 STAT3 PMC10419760__F1 TLR2 MyD88-dependent signaling pathway IRAK1 TRAF6 IRAK4 MYD88 TIRAP TAB3 PMC5662125__F1 Bile acid receptors link nutrient sensing to metabolic regulation CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC7488343__F7 Obesity, ER stress, miRNAs and endothelial function ATF4 XBP1 PMC2862089__F1 Signal transduction pathways and crosstalk activated by insulin/IGF-1 receptor and GPCR systems TSC2 RICTOR TSC1 RIN1 MTOR IRS1 RHEB PMC8904950__F5 Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway PLCG1 E2F8 DDR1 FOXM1 BIRC5 TRIB3 RING1 AHNAK SP100 KIF11 DMD USP14 PDGFA RRM2 EZH2 CENPA NOTCH2 CENPB MYBL2 DACH1 CYP24A1 ACOT11 HUWE1 CBL TXLNA MCM3 GIG8 TRIM44 TCF4 PMC10609929__F2 Modeled DDIs for phenytoin CYP2C9 CYP2C19 CYP3A4 PMC4749929__F2 Pumping the breaks on B cell development ATM BASH SYK SPIC IRF4 PMC7019526__F1 Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase receptor type B (BDNF/TrkB) signaling supports neuronal survival, plasticity, differentiation, and growth via activation of several functional downstream cascades PLCG1 PMC8599992__F9 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability BLM SLX4 EME1 ERCC1 SLX4IP RMI1 PMC8599992__F7 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability FANCD2 NEIL3 SLX4 FANCM ERCC1 PMC3566011__F8 HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion EGFR FURIN PMC6413705__F1 Complement dysregulation in complement-mediated HUS Complement activation initiated by any of the three pathways (classical, alternative, or lectin pathway) leads to C3 activation and C3 convertase formation on C3-opsonized surfaces HEL-S-62p THBD VTN DGKE FH PMC4706579__F3 IL-23/T17 pathogenic axis is an important therapeutic target in psoriasis NFKBIA REL IL23R STAT3 PMC7200161__F6 Schematic model for possible signaling pathway related to the role of ALK7 in mediating BAT responses to nutrient stress KLF15 SMAD2 PMC7558805__F6 Sphingolipid biosynthetic pathways: GHB3 ORM2 ORM1 PMC12022663__F8 Regenerative mechanisms induced by HAps encapsulated in hybrid hydrogels MYH9 FGF2 S100A4 PMC9313589__F1 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma GPX4 RIPK3 MLKL BAX PMC7024062__F1 CS response HEL-S-62p C4B_2 PMC3866163__F11 Global Assessment of Antrodia cinnamomea-Induced MicroRNA Alterations in Hepatocarcinoma Cells BTK CD72 BCL10 BCR RASGRP3 BASH GC CD22 LYN GRB2 SYK CD19 PMC9313589__F2 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma GPX4 RIPK3 MLKL BAX PMC7308516__F2 Microbiota in cerebrovascular disease: A key player and future therapeutic target TLR4 IRAK1 SIGIRR APC MSC TRAF6 IRAK4 MYD88 TSLP PMC9687595__F2 Wound Healing versus Metastasis: Role of Oxidative Stress KEAP1 NOX4 TNF IL1B NQO1 PMC4128061__F2 Activation and regulation of BMP/Smad-dependent signalling BAMBI SMURF2 SMAD6 SMURF1 PMC4490281__F1 Simplified schema demonstrating proposed mGluR–eEF2–AMPAR pathway: Postsynaptic binding of glutamate leads to activation of ionotropic (AMPAR, NMDAR shown) and metabatropic (mGlu1/5 shown) glutamate receptors EEF2K EEF2 ARC EIF4E MTOR PMC8764638__F1 Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema HEL-S-62p C9 PLG C7 C6 PMC6954967__F3 Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2 PLCB4 PDE2A CACNA1C MEF2D PMC7379131__F3 Inflammatory Tumor Microenvironment of GBM and its Therapeutic Implications EGF CCL2 CXCL12 CCL22 FOXP3 PMC9361616__F8 IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis HGF FOXO3A IFITM3 PMC3188430__F7 miR-486 is an important regulator of PTEN/AKT signaling in normal and dystrophic muscle PIK3R1 PTEN PMC7738626__F2 IFN-I response and signaling pathways in malaria parasite infections TBK1 PARP14 CGAS TLR9 HELB HAVCR2 TRAF3 TRAF6 RTP4 MYD88 STAT1 TLR4 INPP4A STAT2 FOSL1 IRF9 RIGI IRF3 IFNAR2 TLR1 IFNAR1 AK3 HELZ2 CD40 TYK2 IFIH1 MAVS PMC8467939__F4 Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory? GOT2 OXCT1 HEL-S-133P PMC7873978__F1 Lipoic acid metabolism pathways in E LIPM LIPA OGDH PMC6349487__F3 TLR2, TLR3 and TLR9 regulate a robust immune response following HSV-1 infection TBK1 TLR9 TRAF6 IRF3 MYD88 TLR3 TIRAP PMC8055972__F8 Regulation of VM formation and NPC metastasis by the miR-124/Foxq1 axis MMP2 MMP9 EGFR FOXQ1 PMC6519375__F7 CLIP‐170 controlling Met RTK recycling in migrating cells HGF PMC9324963__F2 IL‐22 in homeostasis and diseases of the skin STAT1 TYK2 JAK1 MTOR STAT3 PMC6710175__F3 Hepatocellular carcinoma development in the Mat1a knockout mouse BCL2 CYP2E1 PMC7574311__F3 Leaf-specific DEG attributed to photosynthesis are enhanced in SPL13RNAi plants PC ASS1 NDP PMC2442829__F1 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations TSC2 PI3 PTEN MTOR RHEB PMC4246083__F8 NLRP3 regulation by GPSM3 NLRP3 IL16 GPSM3 TPR IL1B PMC2442829__F2 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations EGFR MDM2 MTOR PMC4515859__F3 Biochemical network of arachidonic acid metabolism CPA3 COX2 ALOX15B ALOX12 EPHX2 GPX6 PTGS1 ALOX12B PLA2G10 PTGES3 PMC4833611__F1 Nurr1 pathway and Nurr1‐based therapies for Parkinson's disease RET GDNF HEL-S-66 SP1 PMC7970560__F11 Modulating the PI3K-Akt signaling pathway and MAPK signaling pathway of ginseng against ALI/ARDS BAD TRADD TRAF6 RAC1 MYD88 TNF NLK TLR4 MAX BCR MDM2 GRB2 CCND1 JUND SYK TRAF2 MEF2C CD19 PMC6465620__F1 M6A function in AML MYB SP2 MYC PTEN WTAP PRMT1 METTL14 METTL3 CEBPZ BCL2 EIF3S3 RBM15 VIRMA SP1 PMC8086041__F1 Pulmonary Macrophage Cell Death in Lung Health and Disease CASP3 IL1A IL33 CASP9 CASP8 ZBP1 MLKL GSDMD DFNA5 PMC2915669__F6 Model showing the interorganellar flow of acetyl units in C PDC TES CIT HEL60 PMC5811325__F2 Ras signaling pathways RICTOR MTOR MLST8 PMC3598331__F4 Hindlimb transcriptional regulatory pathway genes suggested to be important in talipes equinovarus pathogenesis RIPPLY2 PITX1 TBX4 PMC6830055__F1 Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance OGT SIRT1 PMC3524227__F1 Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells MCL1 BAX PMC6889404__F1 hnRNPA2B1, an RNA-binding protein, can function as an m6A reader and is involved in RNA transport, processing or splicing TBK1 CGAS JMJD6 HNRNPA2B1 IRF3 IFI16 PMC3680752__F10 A: the top-associated network as defined by Ingenuity Pathway Analysis (IPA) for NAc mRNAs upregulated in HVRs vs TCEA2 ARL2 PARP12 ARHGAP18 PMC11855299__F6 SMG modulates OBD by regulating the activity of both transcriptional and metabolic pathways BMP2 CPT1A SIRT1 PMC4514105__F1 Cell death FADD PMC6222792__F5 Pathway networks related to estrogen receptor alpha HHIP CTH CS ID4 CSF3 FOS F2RL3 LY96 MTOR RAB3B DDIT4 ID3 PHGDH CHST4 CXXC4 FADS2 DHCR7 FDFT1 ASNS HEL114 SESN2 KLRC2 INHBA INHBE PMC4562806__F1 New immunotherapies targeting the PD-1 pathway APC PTEN MTOR BATF PMC4562806__F2 New immunotherapies targeting the PD-1 pathway NFATC1 STAT4 EGFR VEGFA PTEN STAT3 PMC6364001__F8 Proposed model of intracellular pathways engaged within, and functions of, HSV-specific CD8+ T cells from protected ASYMP individuals STAT1 GZMK STAT2 IL2RA TYK2 IL6ST IFNAR2 JAK1 IFNAR1 IL6R IL2RB STAT3 PMC2955764__F1 Sonic hedgehog signaling pathway HHIP SUFU SHH SMO PMC5821903__F1 Schematic overview of anabolic and catabolic signaling in skeletal muscle MYOT IGF1R IGF1 SMAD2 GHR MTOR PMC10675221__F2 Results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis CCR5 CCNA2 MAPK9 HDAC3 MAPK3 GSK3B MAPK14 ALOX5 BCL2L1 HIF1A PDPK1 MMP3 PRKCA NLRP3 STAT1 ITK FLT1 FYN KDR MMP2 MDM2 SRC HDAC2 NOS2 ROCK2 ITGB3 MAPK10 CDC25B TNF HLA-DRB1 HMGCR RXRA EDNRA CDK2 PPP2CA BCL2 MAP3K14 ITGAV MAPK11 FABP1 PLCG1 IGF1R BRAF NR3A2 PGR EGFR ITGA4 RIPK2 MTOR HEL-S-104 CNR1 INSR RXRB BTK TLR4 F2 NGFR PTPN1 CCNB1 PTPN11 IL2 CDK4 CDC2 PTPN6 CYP17A1 JUN RORC MMP9 PTGS2 NTRK1 RXRG PARP1 IL6 CHEK1 HDAC1 CFTR CASP3 RPS6KB1 CPT1A ERBB2 LCK RELA CCNB2 PIK3CA JAK3 SYK JAK1 MCL1 STAT3 PMC10675221__F3 Direct targets of the ethyl acetate extract from decoction of Sargentodoxa cuneata (EAdSc) action on the NOD-like receptor signaling pathway SLA TANK IL2 MCU PMC7884719__F1 BDNF and MAP kinase pathways in combined portrait of depression RBMS1 EFNA1 P2RX7 KRT19 GSK3B HOMER1 SPRY1 TRIB2 DNAJB1 FLNB ITGA2 PRKCA DOCK4 FOSB JUNB BTG2 DUSP4 HPCAL1 APC VEGFA SPRED1 ATF3 RGS2 FGF12 ZMYND11 KCNK1 PHKB IGF1 EGR2 KLF4 ARC DUSP2 BDNF GEM PXDN NF2 RPS6 KLF6 SPRY4 RGS4 BMP2 IER2 IGFBP5 SPRY2 TAGLN HEL-S-102 ANGPT1 LMO4 GAB2 TXNIP NUMA1 PMC7049344__F7 Proposed signaling pathway downstream of CD36 through which oxidized low-density lipoproteins (oxLDL) activate phosphodiesterase 3A (PDE3A) to suppress cyclic adenosine monophosphate (cAMP) signaling PDE3A SYK CD36 PMC7585656__F1 Reactive oxygen species- (ROS-) mediated inhibition of glycolysis reroutes flux into the oxidative arm of the pentose phosphate pathway HEL-75 HEL-S-162eP PMC6301827__F7 Schematic representation of the relationship between Rab1a and the HIF-1a/miR-212-3p/Rab1a regulatory pathway in HCC proliferation and migration RAB1A CDK2 CDK4 HIF1A PMC5993211__F1 Innate Antiviral Immunity in the Skin IFIT3 TBK1 IFIT2 STAT2 IRF7 IRF9 TRAF3 IRF3 STAT1 ISG15 OAS1 OAS2 IRF-1 MAVS IFIT1 PMC2872883__F2 TIF scores for genes in the KEGG colorectal cancer pathway PIK3CD PIK3R1 BAD SET BRAF MAPK8 FOS BIRC5 MAPK3 MYC TCF7L2 RHO RAC1 PIK3R5 LEF1 MAP2K1 APP PIK3CA CCND1 MAPK1 TCF7L1 JUN AKT3 PMC6920888__F8 The anti-melanogenic mechanism of PS and PTS PTS MC1R PMC2872883__F3 Small cell lung cancer PTGS2 TRAF3 TRAF6 BCL2L1 IKBKB BIRC2 NFKB1 TRAF1 RELA BIRC3 PIK3CA CCND1 AKT3 PMC3994550__F1 Insulin signaling pathway PDK2 EIF4E MTOR IRS1 FOXO1 PMC3906328__F1 IL-17 signaling and A20 ANAPC5 RNF11 TRAF6 IL1B NOD2 ITCH PMC7331943__F3 Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression HEL-S-62p PC ACTN1 PDK4 AURKB CD36 PMC5777758__F5 Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors CDKN2B CDK2 CDK4 CDC2 CDKN2A CDK6 PMC9218738__F1 The NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy NLRP3 RIPK1 IL16 TLR4 HEL-S-11 FADD GSDMD PMC5686346__F8 Proposed model of miR-130a mediated dysregulation of mTOR pathway in HGSOC TSC2 TSC1 MTOR PMC3023470__F9 Schematic illustration of the sphingolipid metabolic pathway in CHO cells expressing SPHK1/2 and hSPNS2 SPHK1 SPNS2 SPHK2 PMC7563696__F3 Rho GTPases in spine morphogenesis PAK1 LIMK1 ARHA RAC1 CDC42 PMC3517549__F5 Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses IRAK1 TRAF6 IRAK4 MYD88 SARM1 MAP3K7IP1 MAL PMC5657420__F1 Classical pRb pathway demonstrates the utility of CDK inhibitors, such as palbociclib, in RB+/+ osteosarcoma CDK2 CDK4 CDK6 PMC2955136__F3 Highly expressed proteins in MII oocytes TH POLD2 MAX NONO RELA SATB1 CHD4 SAP30 PMC3677579__F2 Accessory molecules for Toll-like receptors and their function TLR7 TLR4 TLR9 UNC93B1 TLR1 TLR3 PMC2955136__F4 Highly expressed proteins in zygotes EPN2 C4B_2 CS ALB RPN2 UBE2B UBE2D2 TRIM17 RPN1 HEL-S-32 UBE2E1 MDH2 IFNG DBI ABAT B2M AGL APOE PMC7237728__F7 Effect of DFX on Mtb-infected macrophages HIF1A HEL-S-162eP PMC7924562__F1 Momelotinib and CFM4.16 synergistic combination CDC20 CDC2 STAT3 PMC5731741__F4 FGMD: A novel approach for functional gene module detection in cancer CCR5 DOK3 IFFO1 TMEM150B CLEC4E CENTA2 TNFRSF9 TAGAP SLC9A9 IL16 MNDA FGL2 HCLS1 NLRC4 LYZ GPRIN3 GIMAP1 PIK3R5 SIGLEC1 SIRPB2 GIMAP5 GIMAP7 GIMAP8 GAL3ST4 GAB3 TNFRSF18 MS4A6A CD300LF BIN2 SLC37A2 SNX20 FMNL1 NCF1 SIRPB1 CD37 DOCK8 TYMP ITGA4 CSF2RB TLR8 TLR7 TLR4 IGSF6 IKZF1 LILRB2 LILRB4 NPL MYO1F MYO1G CD68 APBB1IP SLA CMKLR1 WDFY4 CCRL2 TLR1 PTPN22 ITGB7 LILRB1 CD180 LHFPL2 MPEG1 TFEC GPR84 PMC6528487__F1 Selected genomic alterations are indicated by an asterisk (*): fibroblast growth factor receptor (FGFR) pathway (FGF19, FGF4, FGF23, FGF3, and FGF6 amplifications) FGF4 FGF23 FRS2 FGF3 FGF6 GRB2 FGF19 MTOR PMC3517549__F1 The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses TBK1 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TIRAP PMC5731741__F3 FGMD: A novel approach for functional gene module detection in cancer KLHL6 CCR2 KBTBD8 CTSS ARHGAP30 CD6 UBASH3A SPN POU2F2 CXCR6 MAP4K1 CCR1 PARP15 ITK TAGAP PIK3AP1 FGD2 CD2 PYHIN1 MYO1G LY9 CD3E PARVG CD3D GZMK VNN2 KCNA3 RUNX3 CD5 BTLA SLAMF7 SIRPG TNLG7A IL12RB1 PLCB2 VCAM1 EPSTI1 LCK SIT1 LYN CD180 BIN2 TRAF3IP3 FMNL1 AKNA TMEM140 APOBEC3C FAM78A PMC11762942__F3 Amino acid metabolism in chondrocytes SOX9 PMC8445033__F1 Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures RIPK1 RIPK3 ZBP1 MLKL PMC4133236__F12 CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ERK, JNK, and AP-1 Pathways CXCR4 RAC1 CXCL12 PMC5988105__F1 Currently approved and available IBD therapies include: four anti-TNF agents, namely infliximab, adalimumab, certolizumab pegol, and golimumab, and two anti-integrin agents, natalizumab and vedolizumab TNF MADCAM1 PMC12003104__F2 Relationship between iron metabolism disorder and diabetes and its complications ATP7B ATP7A ATOX1 CP CCS PMC5652951__F8 Schematic diagram of the role of IL-33 in the regulation of the biological behavior of glioma cells MMP2 MMP9 IL33 PMC8616288__F2 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance TSC1 BCL2A1 GSK3B CCND1 BCL2 TYK2 STAT3 PMC8616288__F3 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance BAD HGF MDM2 CDH2 MTOR BAX PMC5988105__F2 SMAD pathway SMAD2 SMAD4 PMC5101236__F1 Schematic signaling pathways elicited by VEGF KDR FOS NRP1 MYC SOS1 MTOR JUN PMC11762942__F4 Relationship between lipid metabolism and OA pathogenesis CH25H NOX4 CYP7B1 HIF1A PMC6879798__F1 InterferonB signaling pathway regulated by RLRs TANK TRAF3 TRIM25 MAVS PMC526469__F6 Working model for SPRR1A activation in the myocardium SPRR1A LIF IL6 STAT3 PMC9583737__F7 Wnt-mediated fibrosis in CD SMAD2 APC PMC6165231__F1 Hedgehog (Hh) pathway activation SUFU EGFR SHH SMO PMC4221415__F5 Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics NAPSA CSNK1D MAPK9 HEL-S-1 RPS6KA4 MAPK14 PRKAA1 TEC IRAK4 AHNAK EPHB3 BMP2K HINT1 NQO2 WEE1 EPHA1 PAICS TBR1 DEFA1B PRKAG1 PRKAB2 ADK PRKAB1 MCCC2 ABL2 PTK6 LIMK2 THRAP3 MAP3K1 LIMK1 CSK KPRP HRNR STRADA KRT2 DERL1 FER NENF TIMP1 AZI2 KRT3 AIMP2 TNS1 IRAK3 MLKL ALDH2 IKBKE EIF5B MERP1 TANK LIMS3 BRAF HEL2 VAT1 HSP90AB1 EGFR LATS1 YES1 TTN STK33 CHEK2 FECH FRK NME4 PC4 ALDH1A2 YWHAG KRT10 PARVB KRT20 PARVG KIT LRRK2 CAMK2D PRKAA2 HEL-S-53e RIPK3 CAMK2G CDC37 DDR2 AURKA LIMS1 HEL111 MAP2K1 MAP3K2 SYK HEL-S-93 PMC9000186__F7 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury SPHK1 TNF SPHK2 PMC9000186__F8 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury SPHK1 TNF SPHK2 IL1B PMC5835698__F2 Antitumor mechanisms of ivermectin HMGB1 IFIT2 SOX2 ASCC2 FILIP1L IRF9 APC CD44 GPR49 MTOR DKFZp686F0183 OASL PAK1 ISG20 AXIN2 IFIT1 CD24 PMC9000186__F1 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury SPHK1 CERK SPHK2 PMC9504455__F2 Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases TSC2 ULK1 TSC1 TFEB GAA BAX PMC7918477__F1 ER stress and unfolded protein response (UPR) signaling pathway ATF4 EIF2A XBP1 PMC3110678__F3 SAT and PT domains of NSAS in aflatoxin B1biosynthetic pathway CLC HEXA HEL-S-111 PMC3068163__F1 Melanoma Molecular Disease Model GNA11 BAD BRAF NRAS MDM2 CDK4 PTEN MTOR CDK6 BAX PMC8745220__F5 Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis COMP PMC7933806__F2 Sphingolipid networks DES LPP CERK SMS PMC8395582__F5 ErbB signaling pathway map EGF NRG3 BAD NRG2 MYC SHE MTOR CRK CBL BTC GRB2 NRG4 JUN PMC4143607__F5 The role of the PHDs in the cell cycle CEP192 ATR SKP2 PMC6677404__F2 Schematic diagram illustrating a role of PI3K, Rho and ROCK pathways in hypoxia-induced ATP release and ATP-mediated angiogenic effects in vasa vasorum endothelial cells EGR1 FOXO3A ARHA PMC2809919__F2 Epithelial–mesenchymal interactions mediated by the Sonic Hedgehog pathway in the gut GLI3 SHH SMO FOXF1 PMC9524953__F6 Identification of a functional circRNA-miRNA-mRNA regulatory network in infantile hemangioma by bioinformatics analysis HES5 NUMB EPO VHL EIF4E GAL HEL-S-87p HEL-S-133P TF STAT3 HES1 HEL-S-162eP PMC10779236__F5 Possible action mechanisms of sialic acid mediated by the signaling pathway and gut environment GNE TLR4 MYD88 BDNF NQO1 PMC9445361__F6 Score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer FCRL4 COL2A1 TNF MAGEA4 PMC7699575__F2 Glutathione (GSH) biosynthesis pathway GPX4 SLC7A11 SLC3A2 PMC7699575__F1 Ferroptosis pathway GPX4 LPCAT3 FACL4 SLC3A2 PMC5997503__F5 PLATELET LIFELINE TO CANCER: CHALLENGES AND OPPORTUNITIES COX1 VTN TF PMC10179536__F9 Proposed diagram for the therapeutic effect of PRP improved bladder overactivity induced by OHD in rat model CD44 MTOR SOX9 PMC5240474__F2 Inhibition of the NOTCH pathway by NUMB NOTCH2 NOTCH4 NUMB RBPJ JAG2 NOTCH1 ADAM10 CDK8 NOTCH3 ADAM17 PMC4988306__F2 Role of innate immunity in nonalcoholic fatty liver disease progression NLRP3 IL16 TLR4 TLR9 MYD88 PMC10779236__F4 Main molecular mechanisms regulated by sialic acid GNE TLR4 MYD88 TNF BDNF NQO1 PMC8699303__F6 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas HEY2 ECD RIN1 EGFR PTEN MTOR PMC7308183__F6 Protein–protein interaction network of CFTR (GeneMANIA) CCL11 DNAJC5 PRKX EZR ADRB2 CCL4 CFTR CEBPD CLCN3 HEL-S-94n NKX3-2 HEL113 PRKAR1B CXCL12 ABCB1 SLC4A7 PMC8699303__F7 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas DLL4 PMC8946535__F1 From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance BTK BCR BASH IRAK2 LYN SYK PLCG2 IRAK4 PTEN PMC5129989__F6 Higher methylation intensity induced by EBV LMP1 via NFKB/DNMT3b signaling contributes to silencing of PTEN gene PTEN CSA2 TRAF2 PMC7503990__F1 Structure and biosynthesis of fucosylated glycans POFUT1 FUT8 GMDS FUT1 FUT4 FUT6 FUT5 POFUT2 hCG_1998026 FUT7 FUT3 PMC9040139__F4 Immunopathogenesis of alopecia areata JAK3 JAK1 PMC9488956__F2 Hermansky–Pudlak syndrome pulmonary fibrosis: a rare inherited interstitial lung disease HPS4 HPS1 RAB32 PMC9455597__F3 PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies SLFN11 PARG ATR PMC9468871__F3 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer KIT PDGFRA PTPN11 SRC MAPK1 HRAS MTOR PPARG PMC9468871__F4 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer PIK3R1 KIT PTGS2 EGFR PARP1 IL6 MTOR HRAS CASP3 TLR4 IGF1 KDR EP300 PTPN11 MDM2 SRC MAPK1 PPARG STAT3 PMC5438742__F2 MYCN down-regulation by didymin and based on network analyses of our proteomic studies that focused on cancer-related pathways active in NB cells EGF ATF2 EGFR GSK3B MYC MDM2 RHO RALBP1 HIF1A ADRBK1 BACH1 CDC42 PMC7340297__F5 Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients IL10 NGF VEGFA MSTN IL6 MTOR IRS1 NR1C1 FOXO1 PPARGC1B INSR TLR4 IGF1 TRIM63 SLC2A4 PPARGC1A NGFR NFKB1 NR1C2 PPARG NTRK2 PMC4922562__F1 YAP/TAZ mechano-sensing signaling pathway network ARHA MAL PMC6911977__F5 Metabolic pathway for 2,3-butanediol production in yeast (modified, based on S BDH1 GPD2 HEL-S-4 GPD1 PMC12021614__F2 Multiple mechanisms of circRNA in tumor immunomodulation and immunotherapy SMAD2 SMAD4 PMC10848377__F2 Koetjapic acid molecular mechanism in curbing carcinogenesis SMAD2 SMAD4 BCL2 BAX PMC2121320__F2 MTA family of coregulators in nuclear receptor biology and pathology BCAS3 WNT4 HIF1A MTA2 MTA3 PMC8913720__F1 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease CCL8 CCR2 SMAD2 APC GSK3B CCL7 SMO CCL2 DKFZp781O1323 CCL16 PMC2910227__F3 Cellular Functions of Transient Receptor Potential channels BTK PTEN INSR PMC2228275__F3 A signaling network links genes regulated by GCs in CEM cells PIAS2 YAF2 SRM HEL-S-99n MTHFD1 ID1 HDAC1 PMC5891012__F1 Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations EGFR GRB2 PMC3272882__F3 DRD2/GSK3B/DISC1 pathway modified from Beaulieu et al DISC1 DRD2 PMC8913720__F2 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease CCR2 CCL7 CCL2 IL1B CCL16 PMC8017015__F2 Regulated cell death pathways in doxorubicin-induced cardiotoxicity GPX4 ABCB8 HMOX1 TF PMC3812667__F1 Bcl-2 inhibition may act directly on tumor cells but may also target the nutrient supply to the tumor by disrupting the blood vessels that form around, and within, the tumor () CXCL1 CXCL8 IL8RB PMC6880955__F1 Signaling pathways of RIG-I-like receptors (RLRs), cGAS, and AIM2-like receptors (ALRs) TBK1 CGAS IRF3 AIM2 MAVS PMC5998602__F10 The schematic illustrates a model of Long noncoding RNA HULC promotes liver cancer cell growth by inhibition of PTEN via autophagy cooperation to miR15a ATG3 PTEN HRAS SIRT1 PMC3891517__F3 Possible mechanisms of opioid receptor-mediated influence of morphine on tumor growth EGF BAD CCND1 SRC ARHA PMC7647673__F1 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics RNASET2 ELAC2 PMC7647673__F2 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics AGO2 AGO4 RPA1 JAG2 PMC9696119__F5 Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID TBK1 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 IFNLR1 STAT1 TLR8 TLR7 TLR4 TYK2 JAK1 ACE2 IRF-1 MAVS PMC10918910__F1 Mechanisms through which the gut microbiome contributes to oncogenesis CYP2J2 TLR4 AHR CYP1B1 CYP1A1 PMC10918910__F2 AhR activation by microbiome in the tumor microenvironment AHR CYP1B1 APC CYP1A1 PMC10850140__F7 Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study BAD PLAT CDK2 MDM2 GRB2 SRD5A2 PTEN TF PMC3135641__F1 Metabolic target genes of p53 TIGAR SCO2 GPX1 GLS2 SESN1 SESN2 HEL-S-20 PMC7728070__F3 Modulating the autophagic machinery in vascular calcification OGT BNIP3 MTOR HDAC1 PMC6938454__F1 Lab Review: Molecular Dissection of The Signal Transduction Pathways Associated with PTEN Deletion-Induced Optic Nerve Regeneration TSC2 TSC1 GSK3B PTEN PMC5951826__F3 Wnt and Ras-MAPK pathway genes and interacting genes with AURKA, significantly deregulated (DEA) or in the most significantly deregulated gene module (Heinz) in the two cell lines, SW480 and Caco2 UBE2D1 MAP3K6 PDGFRA PPP3CA FOS CTBP1 ALB CASK AURKA DDIT3 CDK6 PRKCA DUSP5 DICER1 HEL-S-80p PPP3R1 LCK KITLG AXIN2 JUN LAT PMC4000109__F2 TGFB signalling cascade alterations that lead to prostate cancer BMP6 NODAL GDF15 TGFB1 PMC6066750__F7 Role of Slfn2 in type I IFN signaling EFS TYK2 IFNAR2 JAK1 IFNAR1 PMC7784996__F3 Metabolism of Methylophaga aminisulidivorans SZUA-1124 SI ACR PMC11675822__F2 NPFF and its receptors’ signaling pathways NPFFR2 NPFFR1 NPFF PMC4106421__F2 ARF impinges both on developmental processes (male germ cell development and ocular development in mice) and tumor angiogenesis ATM PMC5516115__F1 Speculative model on changes in carbon flux during P limitation in a diatom cell PC CIT MAL PMC6534125__F2 Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention PAN3 SMAD2 PAX3 PMC6437556__F1 Vitamin D metabolism and signaling FOXM1 LRP6 CYP24A1 ARHA DKK1 RHO DKK4 CYP27A1 NR1i1 CDKN1A GC HEL-S-70p CYP27B1 PMC4773729__F2 Signaling mechanisms through the Janus kinase (JAK)/STAT pathway and action point of a JAK inhibitor tofacitinib EPO TPO TYK2 JAK3 JAK1 PMC9674619__F4 Mechanism of mutp53 in ferroptosis ELAVL1 GPX4 CDKN1A SLC7A11 DPP4 SLC25A28 PTGS2 ALOX12 GLS2 SLC3A2 BRD7 PMC11810975__F3 Synthesis of Primary BAs and Secondary BAs CYP27A1 CYP8B1 CYP7B1 BAAT CYP7A1 PMC10149902__F12 Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis METRNL APOE PMC6199354__F1 Ubiquitin modifications in the TGFB pathway SAMD3 USP15 USP2 APC TRAF6 ARHA SAMD5 SAMD7 SMURF1 SAMD1 FBXW7 CYLD SMURF2 KLF4 SKI CDC42 PMC4761518__F1 F-BOX proteins in cancer cachexia and muscle wasting: emerging regulators and therapeutic opportunities TSC2 TSC1 IGF1 MSTN MTOR IRS1 PMC6199354__F2 Ubiquitin modifications in the WNT/Beta-catenin pathway ZNRF3 USP15 RNF43 CYLD USP14 SMURF2 APC RNF146 SMURF1 WLS PMC3589701__F3 The epidermal growth factor receptor (EGFR) signaling pathway and molecules that may affect drug resistance ERBB4 HGF ERBB2 ERBB3 EGFR MTOR STAT3 PMC6920770__F4 Angiogenesis activation through reactive oxygen species (ROS) via hypoxia dependent and hypoxia independent pathways MMP2 MMP9 PTEN RAC1 MTOR PMC7736628__F1 Consequences of STING over-activation on antigen presenting cells and T cells following severe acute respiratory syndrome coronaviruses (SARS-CoV-2) infection TBK1 IFIT3 CGAS ULK1 NRF IRF7 IRF3 TNF ACE2 MAVS SLC19A1 PMC3068308__F5 TGFB signaling pathway SMAD2 SMAD4 PMC7940873__F7 LncRNA-mRNA co-expression network analysis PIK3R1 CXCL1 SOCS3 MAP2K4 TRIB3 CREB1 CXCL3 CCL2 EFNA2 CEBPB RIPK1 MAPK12 ATF4 BIRC3 CSF2 IRF-1 JUN RBL2 MMP9 CXCL10 RPS6KA5 RIPK3 FGF16 CXCL2 CREB3 PKN1 YWHAQ EDN1 TNFRSF1B THBS2 RPS6KB2 RELA VTN TNFRSF1A CCL20 CSF1 PMC3043245__F3 Signalling between p53 and the IGF-AKT-mTORC1 pathway TSC2 TSC1 ATM MDM2 PTEN RHEB PMC8796618__F12 MAGEA6 positively regulates MSMO1 and promotes the migration and invasion of oesophageal cancer cells MED25 PC4 MED1 CDK9 MED8 HMGCR MAGEA6 PMC5588408__F1 Canonical and noncanonical inflammasomes NLRP3 NAIP IL16 NLRC4 NLRP1 IFNAR1 AIM2 IL1B PMC9355307__F4 Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues GGH RAB37 CD46 CXCL5 RAB27A NRAS MAPK14 TPO RAP2C PTGS1 PSMD13 VAPA MNDA APAF1 LPL SRPK1 MDM2 MAPK1 DEFA1B CTSA HEL114 B2M SP1 IFNGR1 FGL2 ACTR2 NAMPT BAG3 LCN2 RAB31 PSAP HRAS IFNAR1 PGRMC1 SNAP23 RAB10 ADAR RICTOR ADAM10 MPL CD36 TBK1 CHUK ANXA3 IFNGR2 ZNF175 CD81 OSTF1 NHLRC3 TLR4 BRI3 DYNLT1 APP CD55 TRAPPC1 SLCO4C1 FTH1 RAB7A TNFSF10 APRT RAF1 MME VAMP7 PMC5495879__F3 Overlap of the present results with Greengard’s neurotransmission integration scheme GNG7 DRD2 PDE9A ITPRIP SCGN KCNV1 CATSPERZ GABRA2 NOSIP PPP2R2A RGS6 PPP2R3A PPP2R3C KCNN3 OPRD1 ADCY1 DLG2 CDK5 CHRNB4 NRGN CHRNA3 CHRNA2 KCNB1 KCNJ3 CACNA1I PPP2R2B TRPC4 PDE4B GABBR2 GABBR1 GRM3 TRPM6 ATP2B2 KCNG2 HCN1 ATP2A2 Nucb2 PMC3418560__F5 Schematic representation of a case of malignant myeloid disease evolving in four stages along one pathway RUNX1 ETV6 ASXL1 EZH2 TET2 PMC9574103__F3 Comprehensive analysis of metabolomics and transcriptomics to reveal major metabolic pathways and potential biomarkers of human preeclampsia placenta HSD3B1 UGT1A10 AKR1D1 HSD17B1 CYP1A1 CYP17A1 CYP21A2 PMC7596222__F4 Molecular pathways triggered by eCSF-derived factors EGF FRS2 APC PTCH1 FGF2 SHH LRP6 SMO BDNF SMAD1 DKFZp781O1323 PMC6951466__F4 Ingenuity Pathway Analysis (IPA)‐based plausibility analysis of candidate single nucleotide polymorphisms (SNPs) CCR5 RET MMP2 AGTR1 LEPR ADRB2 GNAS NR1C1 CP RXRA PMC4961118__F1 Quantification of the input-response function of LAT:Grb2:SOS assembly in TCR signaling ZAP70 GRB2 LAT PMC10312032__F2 Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease HEL-S-90n KMO PMC11715079__F1 Cytoplasmic recognition of HAdV DNA occurs through cGAS sensing TBK1 CGAS PDC TLR9 IRF3 MYD88 PMC11715079__F2 Complement activation pathways and antibody neutralization effects of HAdV infection HEL-S-62p C4B_2 TRIM21 C4A PMC8170089__F1 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress NOTCH2 ROCK2 ROCK1 DPP4 SMAD2 ZEB2 TGFBR2 IFNG PMC11715079__F3 T-cells mediated adaptive immune responses RUNX1 APC PCBP1 IFNG PMC8170089__F2 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress ADIPOR2 NPAS3 MAPK7 PTEN PMC4673677__F3 Surviving at a distance: organ specific metastasis SPARC COX2 ANGPTL4 MMP2 VCAM1 IGFBP4 PMC2791157__F3 Decomposition of Gene Expression State Space Trajectories RARA CDK2 RXRA PMC3521191__F1 Biological pathways targeted for therapy in renal cell carcinoma based on a knowledge of the underlying genetic changes and downstream biological consequences VHL CCND1 PTEN PMC10949532__F1 Non-canonical NFKB pathway and its regulation: The non-canonical signaling pathway may be initiated through the binding of a variety of exogenous ligands to their cognate receptors (top right) TBK1 ZFP91 CD27 BCL10 OTUD7B NLRP12 TRAF3 RELB CD40 TRAF2 LTBR STAT3 PMC2989404__F1 Eighteen Insulin-like Growth Factor (IGF) pathway genes, circulating levels of IGF-1 and its binding protein (IGFBP-3), and risk of prostate and breast cancer SST GHR INS GHRHR IGF2R GHRH PMC12034760__F0 FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression RBPJ FBL YY1 CAD PMC4172779__F3 Downstream genes chosen from KEGG annotated in Wnt/Beta-catenin pathway ROCK2 BAMBI STOM APC SOST LRP5 CER1 SMAD4 LRP6 SKP1 ARHA NLK SIAH1 PMC3159114__F10 Role of GPx-1 in modulating apoptosis GPX1 BAX PMC7881565__F6 Distinct pathway for internalisation of MSN, MWCNT, and ZnO NPs in CHO-K1 cells: The proposed mechanism involved MSN and ZnO NPs uptake through clathrin-mediated endocytosis ROCK2 HEL70 ATG12 TUBB M6PR HEL-S-99n RAC1 MRE11A CDK6 MTMR3 ATM RAE1 CDK2 NPS GRB2 CDK4 DOCK3 ATR VPS29 PMC8776968__F4 P21-activated kinases in neural cytoskeletal remodeling and related neurological disorders TIAM1 GPM6A SMO RAC1 CDH2 CYFIP1 CORO1A CDC42 PMC7654650__F2 Stem cells and lung regeneration FOXN4 ASCL1 ASCL3 KRT13 FOXI1 KRT5 KRT4 SCGB1A1 RGS13 FOXJ1 CFTR STAT3 PMC7654650__F4 Stem cells and lung regeneration LAMP3 AQP5 AGER HOPX SFTPC ABCA3 PDPN SCGB1A1 BMP4 PMC6528901__F4 Implications of 15‐LOX‐1 in angiogenesis in different models CD47 ATF2 PMC7304922__F1 Activation of Nrf2 and AhR signaling pathways AHR KEAP1 PAH PMC300841__F1 Usurpation of the Ras signaling pathway by reovirus ERBB2 EGFR GRB2 SRC PMC2390552__F11 ERK1 and ERK2 knockdown differently affect signals involved in patterning of the early embryo FST NOG SPRY4 NODAL TBX6 GSC WWP1 GATA5 SMURF1 SPRY2 PMC4584981__F3 Model representing cross talk between drought and pathogen stress signaling pathway from individual stress studies and its relation to shared and unique response pathway provoked under combined stress MYB MYC ERF PMC9240199__F3 Emerging Roles of Human Gut Microbiota in Gastrointestinal Cancer NRP1 AAG1 SP1 MTOR BAX PMC2768997__F1 Human protein-protein interaction network of aging-associated genes IGF1R BLM EGFR MAPK3 MYC RB1 HDAC1 FEN1 RET EP300 TBP NFKB2 ATM NFKB1 PTPN1 GRB2 IL2 MAPK1 SHC1 PCNA SUMO1 PMC6271345__F6 Proposed mechanisms underlying the cellular responses to t-BHP after pre-treatment with Rb1 via Nrf2/HO-1 signaling pathway MAF KEAP1 RB1 NQO1 PMC4375817__F3 The modulation of downstream signaling pathways of the brain derived neurotrophic factors (BDNF) by glucocorticoids (GCs) GC GRB2 BDNF PMC8434356__F11 New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway BCL2 MTOR BAX PMC7823834__F2 Agents acting on hormone signaling to revert drug resistance in CRC BAD RUNX1 APC FOXO1 BAX PMC2597859__F1 Role of Programmed Cell Death in the Immunopathogenesis of Sepsis BAD TRADD MCL1 FADD BAX PMC8700241__F2 Metabolic Reprogramming of Liver Fibrosis PCK1 FBP1 CPEB4 PDK3 HIF1A PFKP HK2 PMC1440398__F2 CDC maturation upon virus infection IRF3 FADD MAVS PMC3539953__F5 Representation of the “Interferon Signaling” and “Toll-like Receptor Signaling” pathways IFIT3 PIAS1 MYD88 TIRAP BAX PMC4808550__F1 Thyroid hormone-signaling pathway SRC HIF1A MTOR PMC3981821__F4 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus SQLE SOAT2 ACAT1 DHCR7 LIPA EBP COA1 DHCR24 MVK HMGCS1 ACLY HMGCR PMC6904332__F3 Upregulation of SESN2 under ERS and its protective effect on ERS-associated cell death ELF2 ATF4 EIF2A SESN2 TG TRAF2 XBP1 PMC6904332__F4 The expression and effect of SESN2 on immune cells NLRP3 SESN2 TNF IL1B PMC3981821__F6 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus ALDOB G6PC2 PGM2 FBP1 SHMT1 ENO1 GCK PFKL HEL-S-87p MTHFD2 HEL-S-68p HEL-S-162eP HEL-S-49 G6PC3 PSAT1 PKLR PSPH RPIA PRPS1L1 HEL-S-51e HEL107 PGAM1 HEL-S-133P PGAM2 PMC2435618__F2 Pathways involved in cell differentiation, homeostasis and apoptosis in the adult intestinal epithelium, Beta-catenin and TCF4 are expressed in the proliferative compartment, where are located the intestinal epithelial stem cells IHH SHH TCF4 PMC12191890__F5 Calcium signaling regulation in keratinocytes TRPC1 CASR FOS ATP2A2 JUN PMC12191890__F6 Signaling pathways regulating epidermal homeostasis TSC2 EGF TSC1 ATM JAG2 NOTCH1 BCL2 PTEN ATR JUN RHEB BAX PMC9089305__F8 Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway KEAP1 GCLC HMOX1 PMC9025760__F2 Characterization and Roles of Membrane Lipids in Fatty Liver Disease MFN2 PC PEMT PMC9099743__F1 Advances in Understanding the Genetic Basis of Fatty Acids Biosynthesis in Perilla: An Update DGAT1 PC DGAT2 PMC10538549__F3 cGAS-STING signaling pathway in intestinal homeostasis and diseases CGAS IL1B PMC10538549__F1 cGAS-STING signaling pathway in intestinal homeostasis and diseases TBK1 ENPP1 CGAS STAT2 IRF9 IRF3 TYK2 SLC46A2 IL1B IFI16 STAT3 SLC19A1 PMC10538549__F2 cGAS-STING signaling pathway in intestinal homeostasis and diseases IL10 MUC1 IL18 AREG IL4 IL5 TFF3 MUC2 LAT PMC11012409__F1 Agnostic Administration of Targeted Anticancer Drugs: Looking for a Balance between Hype and Caution RET BRAF NTRK1 NTRK3 NTRK2 BRCA1 PMC4373890__F2 Towards Anatomic Scale Agent-Based Modeling with a Massively Parallel Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT_HPC) TLR4 PTEN DKK1 STAT3 PMC4313349__F1 Nutrient Sensing Mechanisms and Pathways VCP HMGCR CD36 PMC7465272__F1 STAT activation pathway with opportunities for inhibition SOCS2 EPO CS SOCS3 LIF EGFR NOX4 MTOR ADAM17 FOXP3 GRB2 SRC OSM SOCS1 BAX PMC6321520__F1 Expression of Insulin/IGF signaling components is modulated by miRNAs BAD IGF1 PTPN1 IGF2 GRB2 PTEN MTOR IRS1 PHLPP1 PMC5907833__F3 Regulation of KLFs in ECs KLF4 KLF2 PMC7934645__F2 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases VEGFC NCOR1 HDAC3 FOXF2 TIMP3 EGFR FOXQ1 IRF2BPL SFRP1 FOXC2 TF PMC7934645__F3 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases KIF7 FOXF2 SUFU SMO SPOP PMC4796284__F1 Postulated mechanism of PDGF-C-mediated liver fibrosis and tumor in Smad3-dependent and -independent signaling pathways PDGFRA PMC4074033__F6 Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway ATM ATR PMC7934645__F1 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases FOXF2 ZEB2 PTEN SP1 SMAD1 BMP4 PMC8125482__F3 Multifaceted Roles of USP15 in Signal Transduction USP15 MDM2 MTOR PMC4988688__F2 Hedgehog (HH) signaling pathways SUFU PTCH1 SMO PMC4988688__F3 Activation and molecular crosstalk amongst signaling pathways EGF BRAF SUFU EGFR LRP5 LRP6 SMO PTEN AXIN2 PMC9315126__F5 Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target PIG59 IKBKE TRADD BAG3 TGFBR2 AIFM1 MAP3K7 LMNA CRIPT HEL-S-31 ZBP1 GAS2 CASP3 DFFB DFFA RP1 BCL2 RP2 PYCARD CASP8 FADD ACIN1 PMC8326438__F10 Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models ABCC3 CHST13 HELB AKR1C1 IGSF3 PTGS1 RHBDF1 BCR ATXN2L TRIOBP MRPS30 AREG CD63 SNAP23 VPS37D RHEB VEGFC TRPC1 TAF4B SYNM LMCD1 CRIM1 CTCF SHANK3 WFS1 XBP1 CLU DAG1 CAP2 BRI3 GPN3 GMFG FH GPR132 THBS1 RRP1 RASSF2 SYDE1 GOLGA5 DLAT ZNF169 SCARA3 ARMC9 CD19 FRMD5 RHOBTB1 KIT AQP11 LIAS CYB5R1 ACVR1 TMEM132A DCLK2 HEL-S-25 ZNF414 SLC35F5 NASP C1QL1 RPUSD2 RAB17 TMBIM1 ARHA RAC1 TRABD CREG2 PLEKHH1 PRKD1 PTPRF RPS3A CTSZ TMEM106B SYK CHSY3 NGRN HEL-S-43 CAST ARID2 PNN HSPB8 BIRC7 NPEPL1 ACSS1 ILF3 PHIP ARHGAP5 TGFBR3 FASTK WIPF1 PBX2 LAMA3 AHNAK2 MCM6 SHISA4 AMOTL2 CTNND1 ARHGAP21 CD37 HGF EGFR PTEN GPC1 PRP4K CD2 ARHGAP29 HMGB1 PGM3 FTH1 RCC2 NOL3 TMED10 RBPMS TRIM13 VAMP3 SRGAP1 HNRNPC TFAP2C FLT3 RAN ACADM PMC4002948__F7 Possible molecular mechanisms by which Alpha-TOS overcomes the resistance of erbB2-expressing cells to apoptosis and sensitizes them to hrTRAIL-induced apoptosis HEL-S-62p C9 ERBB2 PMC11594131__F5 Possible ways of protective action of MKs and MKT in signaling and metabolic pathways under oxidative stress and heavy physical exercise PINK1 NRF1 PDK4 MTOR NR1C1 SIRT1 PMC1832185__F2 Dose-dependent entry routes for the EGFR EGF EGFR PMC7696406__F8A 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells CD14 DAO MAX TRADD ECSIT TNF MEF2C PMC8468661__F7 Mitochondrial Disruption by Amyloid Beta 42 Identified by Proteomics and Pathway Mapping MYH9 SLC25A24 PAFAH1B1 ALB CADPS2 CPNE1 SSR4 FAT1 HEL-S-69p FKBP1A SLC25A12 MYL12A SLC25A13 TRPV2 PKIA PLA2G3 LETM1 DSG3 PMC7610307__F3 GSK 3B regulates the key signaling proteins of the Wnt pathway APC GSK3B LRP5 CCND1 LRP6 PMC7460588__F1 Canonical Wnt signaling pathway ZNRF3 LEF1 SIAH1 RNF43 APC LRP5 CCND1 LRP6 DKK1 BCL9 PMC4163887__F1 Role of Toll-like receptors during RSV infection TLR7 TLR4 MYD88 TLR3 PMC7610307__F4 Tumor inhibitory role of GSK 3B GSK3B CCND1 PTEN PMC9266588__F3 Amino acid biosynthesis in Cyclocarya paliurus CS HEL107 HEL-S-162eP PMC7435507__F1 Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection HEL-S-62p UMPS CAD DHODH PMC7903655__F2 Mechanism by which MSCs regulate macrophage polarization in the context of SCI CCR5 CCR2 CCL5 CCL2 ARG1 PMC6299067__F2 Lysophosphatidic Acid 's effects on ion channel regulation RHO LPA TRPV1 PMC8998506__F3 Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease BACE1 CCPG1 RTN3 ATL3 XBP1 PMC5348391__F9 Neurokinin-1 receptor is a novel positive regulator of Wnt/Beta-catenin signaling in melanogenesis APC GSK3B PMC4673168__F5 ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma GNA11 NF1 KIT BRAF AREG GRB2 MTOR PMC7683158__F2 SUMOylation in the hypoxia pathway CBX4 SENP3 PMC7683158__F3 SUMOylation in the nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) pathway ATM SENP2 CSA2 PMC2717887__F2 Clusterin as a critical signaling node LEP MYBL2 MMP25 VTN TGFBR2 PON1 JUND JUN CLU PMC12150400__F3 Interaction between Trp metabolites and OA MMP3 COX2 ADAMTS5 AHR SMAD2 NOX4 SIRT1 SOX9 PMC1934514__F4 Schema outlining the signaling mechanisms reported to be involved in GLP-1R-induced differentiation/neogenesis of pancreatic precursor cells, proliferation and in the prevention of apoptosis PI3 BTC BMP2 EGFR MTOR PMC12150400__F4 Interaction between Trp metabolites and OP HGF RUNX2 NFATC1 BMP2 TRAF6 PTEN NSD2 MTOR SMURF1 SIRT3 NLRP3 PRMT1 AHR ATF4 SMAD1 SIRT1 PMC1934514__F2 Mechanisms of Action of GLP-1 in the Pancreas EGF PI3 HEL-S-11 MTOR FOXO1 PMC12150400__F6 Interaction between Trp metabolites and AS IL10 CRP TNF STAT3 FOXP3 PMC12150400__F1 Three pathways of Trp metabolism in the human body ASMT KYNU KMO AANAT PMC12150400__F2 Bioactive effect of Trp metabolites in bone-related cells RUNX2 FOXO3A NFATC1 COA1 ACKR3 SMAD4 GAST CTGF AANAT SOX9 ADAMTS4 AHR CXCR4 MSC CXCL12 SMAD1 SIRT1 PCNA PMC2777399__F1 Regulatory mechanism of the Rho/ROCK pathway activated by angiotensin II (ANG II) in vascular smooth muscles cells (VSMCs, see text) EGFR ARHA SLK PMC11311281__F4 PAR2-induced Beta-catenin stabilization and targets of RNF43 RNF43 PTEN PMC8705244__F2 Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets PARP14 KYAT3 TPH1 KYAT1 PARP10 NNMT TPH2 MAOA AADAT ART3 NMNAT3 HTR1F HCAR3 NMRK1 PARP16 PARP8 HAAO INMT HEL-S-90n AHR KYNU GOT2 NMNAT1 DDC KMO SIRT5 NMNAT2 NADSYN1 NAMPT HTR4 HTR3E AANAT PARP3 HTR3C ASMT NAPRT SLC7A5 IDO1 NMRK2 AFMID TIPARP PMC3670237__F2 STAT3 regulation of and by microRNAs in development and disease SRC JUND JAK1 STAT3 PMC6402958__F7 Models of TGFB superfamily signaling and Harmine-TGFB superfamily actions on human beta cell proliferation FOXM1 CDK2 E2F2 SMAD2 MYC SMAD6 MEN1 SMAD4 CDC2 GDF11 DYRK1A PMC4003231__F1 Immune pathogenesis of gastric mucosa damage in H CCL20 FADD PMC3589238__F6 Networks wherein various signaling pathways epigenetically affected by MXC exposure intersect and the relationships between affected molecules IGF1R IGF1 MAX PGR SMAD2 PTEN HRAS CP INSR PMC6333638__F3 Cell-intrinsic PD-L1 in modulating signaling pathway BMI1 MTOR C4A STAT3 PMC3958665__F6 KEGG pathway for Huntington's disease (proteins identified in our study of the PBMC proteome are highlighted by red stars) HEL70 SET TAP2 TBP REST BAX PMC6319582__F7 Diagram of knockdown of TFPI-anchored endothelial cells induced a more severe LPS-induced acute lung injury via NFKB signaling pathway TLR4 TFPI VCAM1 TNF ACE2 PMC5751326__F1 InterferonB (IFNB) signaling pathways and autocrine/paracrine loop STAT1 TLR7 TLR4 TLR9 STAT2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 AFF2 PMC5751326__F2 Role of IFNB in host–pathogen interaction in Mtb infection TBK1 NLRP3 CGAS IRF3 AIM2 IL1B PMC7683158__F1 SUMOylation pathway MYC MDM2 PTEN BRCA1 PMC9171887__F1 SARS-CoV2 and mitochondria: the impact on cell fate ATF2 BCL2 MCL1 PMC2639747__F2 Smad3 in TGFB–mediated proapoptotic transcriptional responses GADD45B BCL2 MTOR PMC5473921__F2 Network of organismal abnormalities and cancer S100A16 S100P HSD17B12 TMSB10 RPN2 TOMM40 S100A1 LPXN CALD1 GLRX PMC2639747__F1 Smad3 in TGFB–induced antiproliferative transcriptional responses E2F4 E2F5 SMAD4 SP1 PMC7831445__F3 The innate immune response to human coronavirus infection TBK1 CGAS STAT2 IRF7 IRF9 IRF3 MYD88 TLR3 STAT1 ISG15 TLR8 TLR7 TYK2 JAK1 NOS2 ACE2 TMPRSS2 MAVS PMC8505811__F2 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease CS TRAF6 PMC8505811__F1 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease NFATC1 SMAD2 SMAD4 TRAF6 MTOR PMC3859915__F2 Signaling downstream IL-2/IL-15RB JAK3 JAK1 MTOR PMC3376493__F4 A Human Homeotic Transformation Resulting from Mutations in PLCB4 and GNAI3 Causes Auriculocondylar Syndrome PLCB4 EDN1 PLCB3 DLX6 EDNRA GNAI3 DLX5 PMC7865811__F3 NFKB pathway by NLRX1 NLRX1 TRAF6 MYD88 MAVS PMC6291014__F1 Signaling pathways linking EphA and RhoA in regulation of cell adhesion/repulsion PAK1 SRC ARHA RHO CDC42 PMC7572606__F1 MYC transcriptionally upregulates the glutamine metabolism pathway SUMO3 HLA-E ACACA MYC ATF1 SAE1 MYD88 MTOR SMARCC1 ZC3HAV1 RIPK1 SLC25A11 OAS3 ADSL RRM2 PAICS FAT10 HEL-S-70p CAD SP1 MVP HK2 BTN3A3 PFAS SLC25A10 FBL PLAUR LAMP3 STAT2 BST2 TRIM25 ADAR NFKBIA OGFR UBA2 NOP56 PARP12 TFF1 HEL-75 TXNIP HEL-S-51e ELF4 CSDE1 GLS PSME2 PMC6291014__F4 A model of EphB forward signaling regulating cell-ECM adhesion MMP2 RAC1 EPHB2 PMC5706935__F1 PARK2 loss connects AMPK-mediated nitrosative stress to PI3K/AKT activation EGFR SRC PTEN CAMKK2 PMC6009929__F1 Synthetic pathway for preparation of II-V [reagents; i = NC-CH2-CN, ii = (CH3CO)2CH2, iii = (NH2)2C = NH, iv = NH2NH2, v = MeI] COCH CPD PMC8076597__F1 Road of Solid Tumor Survival: From Drug-Induced Endoplasmic Reticulum Stress to Drug Resistance RIPK1 MAPK9 ATG12 MAPK8 BAG3 ATF4 HSF1 TRAF2 XBP1 DKFZp686F0183 TERT PMC3286676__F1 Thyroid iodide efflux: a team effort? TSHR DUOX2 TPO TG PMC4867322__F1 The Hippo signal transduction network and its links to exercise-associated signals and signalling modules TEAD3 TSC1 MAP2 BAG3 VGLL4 TEAD4 LATS1 PTEN MCAT TEAD2 PMC3742302__F6 Omics-Based Molecular Target and Biomarker Identification ATM MDM2 CDC25B ATR PMC3630382__F7 Ingenity Pathway Analysis (IPA) from genes with loss of heterozygosity and somatic mutation (sample G05) MLNR MED4 KPG_011 TAAR8 RB1 GATA2 TRIM13 GPR174 MAST2 VN1R2 DLEU7 KPNA3 HTR2A GPR162 PMC3630382__F8 "Cancer, Hematological Disease, Cell Cycle" Network CREG1 NPM1 UBN1 GPSM3 CEBPA NGB GATA2 MAST2 INSRR RPS6KA1 MNDA RNF112 TRA2B TLL2 GH1 EMCN RAD21 PROK1 PMC3630382__F9 Major interaction in top network ARHGEF5 NPM1 TRA2B CEBPA GATA2 PMC5098112__F6 Manually curated version of RISN BAD APC BOLA1 PMC9609926__F4 Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease TANK STAT2 IRF7 IRF9 TRAF6 IRF3 TYK2 FADD TLR3 MAVS TAB3 PMC8601392__F4 Dynamic Interaction Between Mucosal Immunity and Microbiota Drives Nose and Pharynx Homeostasis of Common Carp (Cyprinus carpio) After SVCV Infection CLPS MADD APP CD40 TRIM25 tal-1 PMC8987327__F5 Prolyl hydroxylase domain proteins in bone metabolism CDK9 TET2 TET1 BRD4 PMC9042931__F4 Protein–protein interaction networks between NAD+ and associated regulatory proteins implicated in heart aging RELA INS MTOR FADD STRADA BAX SIRT3 PMC8592830__F1 Regulatory host factors and interacting viral proteins of the RLR-mediated antiviral signaling pathway USP19 HDAC3 PLK1 GSK3B TRAF3 PLA1A UBE2S CYLD HEL-117 TRIM35 MFN1 UBXN1 c-fgr PLP2 IRF7 FOSL1 IRF3 YOD1 TRIM9 SMURF2 HEL-S-276 MAVS MYSM1 ITCH IFIT3 TBK1 OTUB2 TRIM21 NLRP2 MSX1 RNF5 LGALS3BP PCBP1 OTUD4 RNF115 TRIM25 TRIM26 NLK UBQLN2 OGT LCK GPATCH3 TIPARP RNF128 TRIM24 WDR82 TTLL12 ASB8 DYRK2 RNF166 PMC9042931__F2 Schematic diagram illustrating intracellular pathways of NAD+ synthesis, NAD+ metabolism, and NAD+ signaling pathway in mitochondria NAMPT NADK NNT NMNAT3 SLC29A1 NRK SIRT3 SLC12A8 SLC25A51 SLC5A8 SLC29A4 SLC29A3 BAX PMC3976587__F7 Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements TANK SOCS3 TRADD MAPK8 IRAK1 IRAK2 TGFBR1 TGFBR2 TRAF6 CASP2 MYD88 RIPK2 CEBPB CITED2 RIPK1 SP1 CASP8 JUN RUNX3 RUNX1 RIPK3 TNF MAP3K7IP1 TNLG7A TNFRSF1B TRAF5 TIFA TNFSF10 STK4 BCL2 CDC42 PMC8592830__F2 Regulatory host factors and interacting viral proteins of the cGAS-mediated antiviral signaling pathway TBK1 CGAS ENPP1 PIN1 USP21 IFITM3 TRAF6 HSPD1 USP49 SENP2 USP18 SNX8 RNF5 AMFR NSD3 CYLD ATF4 PTPN1 NMI DDX5 USP22 ATG9A IRF-1 RNF115 OTUD1 IRF7 CSK RBCK1 NLRX1 USP20 IRF3 ZDHHC1 TRIM29 TRIM26 DDX56 AGO2 TRIM28 USP44 OTUD5 PMC2563180__F3 The cardiofaciocutaneous syndrome BRAF HRAS PMC3045531__F9 Snail repressor is required for PMC ingression in the sea urchin embryo HEL23 PMC7307344__F1 LncRNAs in osteosarcoma via PI3K/Akt signaling pathway PMC1899931__F8 Theoretical model depicting potential interactions in the intra-S checkpoint signaling pathway TIMELESS TOPBP1 ATRIP ATR PMC4996735__F1 Redox signaling: an evolution from free radicals to aging KEAP1 SRC NQO1 PMC8978522__F6 RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4‐TRIF pathway TLR4 TRAF3 IRF3 TOPORS STAT3 PMC6726644__F9 Schematic overview of metabolic pathways of P HEL111 HEXA DAP REST AMT DMPK PMC7901903__F1 Gasdermins in pore formation and pyroptotic cell death GSDMA RHO GSDMB GSDMD DFNA5 PMC4303254__F3 Gene product interaction network of immune and inflammatory responsive genes associated with smoking in females generated from the information in the Ingenuity knowledge base, version 7.6 ZFYVE28 MYRIP KLRF1 PROS1 PHLDB2 DNAH12 TNFSF6 KLRG1 ACRBP RGS6 HEL-S-133P CACNA2D2 TXK PRSS23 SLAMF7 RAB6B NCR1 MYBL1 SH2D2A SMOX GRB2 MYLK PRDM5 F13A1 DHRS2 NMUR1 F2R SPON2 GPR68 GNLY CLU PRNP PDGFA GZMA GNAZ RAB27B CHCHD2 LTK PTGDR ME1 ELL3 BMP2 PF4 DNM3 AUTS2 CCR4 PBX1 DLG5 PPP2R2B HNF4A KLRB1 KIF20A TBXA2R GGTA1 PMC8822281__F6 miR-3132 upregulates surface TRAIL to induce apoptotic cell death in cancer cells TBK1 IRF9 IRF3 MYD88 PMC8226237__F3 Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes RUNX2 NONO TRIM68 RANBP9 HSPA4 PMC12075064__F2 Pathway insertion strategy into a Δadh P TH BAD HBD PMC6441206__F3 Regulatory network of ferroptosis GPX4 CDO1 PHKG2 KEAP1 SLC7A11 CISD1 MT1G IREB2 VDAC3 IPP EGLN1 BAP1 PMC138699__F1 Simplified diagram of the canonical Wnt/Beta-catenin signaling pathway APC GSK3B PMC11960914__F9 Schematic diagram of PHB1 and PHB2 expression in blood vessel wall cells and the possible molecular pathways in terms of adhesion of ECs and proliferation, migration, and autophagy of VSMCs VCAM1 MMP9 CCND1 MTOR PMC8026611__F7 Ferroptosis: molecular mechanisms and health implications IL10 GPX4 RAB27A SLC7A11 IFNGR2 DKFZp686F0183 IFNG STAT1 AGER SLC3A2 JAK1 ARG1 IFNGR1 TGFB1 STAT3 PMC8026611__F2 Ferroptosis: molecular mechanisms and health implications GPX4 LPCAT3 FACL4 SLC7A11 ACACA DPP4 TFRC POR TXN AIFM2 NOS2 FASN SQLE CTH STEAP3 FTH1 GCLC CHMP5 FTL GLS2 HEL110 RAB7A VDAC3 PEX3 HMGCR SLC38A1 CHMP6 FDFT1 HEL-S-64p PEX10 ADA TPD52 SLC3A2 SLC40A1 SLC11A2 TF PMC4561113__F3 Notch-signalling pathway in macrophage reprogramming and its interaction with the TLR-dependent signalling pathway TLR4 SOCS3 IRF8 TF STAT3 PMC3875397__F1 FOXO transcription factors throughout T cell biology TSC2 TSC1 ATM KLF2 PTEN CTLA4 RHEB BCL6 FOXP3 PMC8026611__F5 Ferroptosis: molecular mechanisms and health implications GCLM GPX4 KEAP1 SLC7A11 GCLC FTH1 NFE2L2 FTL HMOX1 MAF FECH MT1G HEL-S-64p HEL-75 SLC40A1 ALDH3A1 PMC3635988__F12 HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1 IRF7 IRAK1 IFNAR2 MYD88 IFNAR1 PMC1862519__F1 Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons PI3 GRB2 SHE BDNF PMC3640296__F2 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches HEL-S-28 CXCR4 CD44 HK2 STAT3 PMC3640296__F3 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches IGF1 HEL-S-28 CXCR4 MTOR STAT3 PMC8906750__F1 Monolignol pathway metabolite levels in the C. hassleriana seed coat DAP CAD PMC6635480__F1 Targeting pathways and molecules in the treatment of NMSC PI3 BAD SUFU EGFR MDM2 SMO MTOR PMC9366312__F3 Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis INHA HEL-S-5 PMC9231138__F11 Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U−2 OS Cells through CD44 and Chemokine Signaling CD44 CXCL8 IL6 FOXO1 STAT3 PMC10855920__F2 Innate and adaptative immune systems TRAF3 TRAF6 IRF3 MYD88 TLR3 TAB3 PMC10855920__F4 Molecular pathways hypothesized to be involved in the pathogenesis of nonspecific orbital inflammation CXCR3 IL33 TRAF3 CCL17 TRAF6 IRF3 MYD88 TNF IFNG PMC8283099__F5 Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude IFNL3 HEL-75 IFNL4 PMC9102749__F6 System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats RARA DAO KRT19 SHE BCL2 POR HEL-S-130P TF PMC12065145__F7 Schematic diagram illustrates the mechanism by which high Hcy levels promote hypertension GPX1 PMC4395781__F6 Representation of the proposed mechanism of action for CM-hfMSCs on insulin-like growth factor (IGF)-expressing cells IGF1R CCND1 IGFBP2 IRS1 PMC9035223__F1 Fleshy fruit ripening: from transcription factors to epigenetic modifications MYB ARF4 ERF PMC10474116__F3 Pathways of mitochondrial quality control NRF1 ATF4 FUNDC1 YME1L1 ATF5 BNIP3 CLPP PMC1974879__F1 Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src FST FHL1 TFPI SRC ALOX5 AHNAK TGFBI PMC108887__F9 The CD5-induced signaling pathway, which is mediated by PI 3-kinase and Vav, resulting in the activation of Rac1 FYN CD5 LCK PMC4145816__F1 Ras/MAPK signaling cascade and small molecule inhibition BRAF GRB2 SOS1 PMC8541918__F4 Compartmentation of the Wnt pathway by LLPS APC GSK3B LRP5 LRP6 PMC8541918__F5 Phosphorylation regulates Hippo pathway LLPS LATS1 WAS LATS2 PMC10474116__F4 Apoptotic signaling pathways APAF1 BIK FADD BAX PMC4456143__F2 Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer APC SOST GSK3B LRP5 LRP6 PMC5097896__F6 The Activin/TGFB mediated Smad2/3 signaling pathway NODAL SMAD4 PMC10751868__F5 H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer SNAI1 HNRNPA2B1 PMC8716617__F2 Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells PIEZO1 ARHA RAC1 PANX1 THY1 PMC8506768__F6 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis FHIT RET BAD RASSF1 HGF POLK EGFR JAK3 RAN BAX PMC3634910__F1 Nutrient Signaling to mTOR and Cell Growth NF1 TSC2 TSC1 TBC1D7 GRB2 PTEN RHEB PMC3634910__F2 Nutrient Signaling to mTOR and Cell Growth TSC2 TSC1 TBC1D7 MTOR RHEB PMC3634910__F3 Nutrient Signaling to mTOR and Cell Growth TSC2 TSC1 TBC1D7 RHEB PMC9138746__F3 Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer PLK1 A2M CRIPTO GSK3B FADD PMC7057487__F4 Interactive network for the 8 enriched signaling transduction pathways PRKCZ IGF1R BRAF PLA2G2E GSK3B PLCG2 KCNMA1 CACNA2D1 TAOK1 CACNA1C NF1 FGFR1 MAPK1 LAMC2 RELN KIT IL1A ITGA2B PLA2G6 MAPK10 NRG2 ITGB1 GRIA2 ATP2B1 BRCA1 NFATC3 TSC2 TIAM1 CREBBP EDNRB PDGFC THBS2 KRIT1 GLI3 ATP2B2 PLA2G3 GRB2 PPP2CA MC2R SHC4 NRG4 ACOX3 MYLK3 GNB1 PLA2G10 ADCY9 PMC7840724__F8 Schematic model for radiation induced opposite invasion and migration potential in HCT116 and DLD-1 cells ANXA2 GSK3B PMC4931107__F1 snR81 box H/ACA RNP-catalyzed pseudouridylation GC NHP2 GAR1 NOP10 PMC2955618__F6 Runx2-regulated cancer-related gene network BAMBI NPTX2 MYC GRIN3A SNAI2 NR2F1 SLPI PTGS1 POLE2 CDCA7 EZH2 CSF2 NKX3-1 VRK1 CST7 LYAR RUNX3 EPHX1 AACS DLG2 CD82 PSMC3IP VEGFA LCN2 ATF3 BARD1 RGS2 CEBPA HTRA1 CDC6 PGC DMBT1 SPHK1 MERTK SLC40A1 HIPK2 LOXL4 RUNX2 LRP8 ACHE ITIH4 SHBG STS E2F2 GDF15 GBP2 VTCN1 GJB2 THBS1 TM4SF1 GMNN SPSB1 MAFB RUNX1 TFPI CTDSPL SMAD6 PTGER4 SIDT2 SPDEF SLC16A3 ST14 IL3 TNFSF10 PMAIP1 EDN2 TOB1 SKP2 PMC7864581__F7 Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling MIB1 RUNX2 USP9X NOTCH1 HEL-S-162eP PMC2724780__F1 Bile acid modulation of death and survival transduction pathways CASP3 BAD CASP9 FADD PMC3899118__F5 Genome Wide Expression Analysis Suggests Perturbation of Vascular Homeostasis during High Altitude Pulmonary Edema MAP2K2 CPT2 SSTR2 NFATC3 FZD9 EDNRA TSHR CCL24 UTS2 DSG4 PRKAG2 ACADM FGF7 PMC7450103__F1 Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target PFAS ADSL PAICS HEL-S-70p PMC7814972__F1 Deoxynivalenol (DON)biosynthetic pathway TRIL MVD FDPS MVK PMC7189445__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAcylation NAGK PGM3 OGA OGT PMC6361427__F8 Fine mapping of the major QTL for seed coat color in Brassica rapa var. Yellow Sarson by use of NIL populations and transcriptome sequencing for identification of the candidate genes PDC CAD PMC11413889__F9 MetaCore pathway analysis of Schlafen 5 (SLFN5) co-expressed genes in COAD patients from TCGA RAP1A CAST TNFSF10 CXCR4 CCL2 STAR PNP PMC4742192__F10 Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer CASP3 ATF4 EIF2A CASP9 BAX PMC5891592__F2 CXCR4–CXCR7 crosstalk affecting signaling pathways CXCR4 CXCL12 CXCL11 PMC10531073__F3 Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients MYADM HEL70 ANXA1 CPOX PGAM4 ANXA6 ATP2A2 RB1 HEL-S-7 ATP2B3 PYGL RAB10 PMC10958717__F2 Oxidized lipids and cholesterol affect MSC differentiation EGF RUNX2 EBP MSC PMC6168163__F2 Maintaining maximal metabolic flux by gene expression control CRP TF ELL PMC5022012__F4 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population IQGAP1 KCNC2 AKAP5 PRKACG PMC6522716__F5 Differential expression and bioinformatics analysis of circRNA in osteosarcoma PI3 PTEN IPP PMC11638432__F6 The mechanism of PTX3 regulation of innate immunity and ferroptosis after LPS challenge CCR6 CCL20 PTX3 PMC5022012__F3 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population KCNQ2 USP2 AP2M1 TP73 NR3B3 ARNT2 HSPA4 CP PMC9121581__F5 Potential effects and mechanisms of hispidulin in the treatment of diabetic retinopathy based on network pharmacology TSC2 BAD CD37 BCR MDM2 CYC1 SYK PTEN EIF4E MTOR RBL2 CD19 PMC8775349__F1 Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation CD14 IRAK1 SMAD2 CD83 KLRG1 IL1B GATA3 FOXP3 PMC2981611__F1 Wnt Signaling and Mammary Stem Cells LRP5 SRC LRP6 RYK ROR2 PMC5120243__F5 Network model for CTNNB1 and related genes NR5A2 SNAI1 HGF EGFR GSK3B MYC SMAD4 EPHA8 SMARCA4 JUP SI GC PTPN1 NOTCH1 CCND1 MSH3 ICE1 SS18 APC TCF7L2 ARHA CTNNA1 CARD11 LEF1 CREBBP TWIST1 ERBB2 PTCH1 IQGAP1 CTNND1 EPHA2 CTNND2 PMC8909289__F1 miRNA-Dependent Regulation of AKT1 Phosphorylation EGF TENT2 PMC12204025__F2 Canonical insulin signaling pathway GSK3B IRS1 INSR PMC9129976__F3 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway BACE1 PRKCE MPO NR3A2 ALK EGFR CA14 CA13 ALOX12 TOP2A PTGS1 ESRRA HEL-S-104 INSR PTPRS AHR KDR SHBG MMP2 F2 APP SRC BCHE NR1H3 AXL RORC PTGS2 HEL-S-130P MPG AURKB TNKS2 UBA2 CCNB2 NEK2 ABCC1 NR1C2 SYK MCL1 CA12 BRD2 PYGL MYLK PMC9459425__F1 Cold adaptation strategies in plants—An emerging role of epigenetics and antifreeze proteins to engineer cold resilient plants ICE1 CBL PMC9129976__F4 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway RORC MPO PTGS2 MMP9 EGFR PTGS1 NR1C1 INSR MMP3 PTPRS AHR MMP2 HEL-S-11 F2 ABCG2 NOS2 PPARG ABCB1 PMC12239985__F3 Hypoxia-inducible factor 1-alpha (HIF-1A) signaling pathway EDN1 EGF EPO ENO1 PFKL HEL-S-87p HMOX1 HEL-S-133P TF PMC2601664__F1 Membrane-initiated Estrogen Signaling in Hypothalamic Neurons EGF EGFR SRC HBEGF PMC8790028__F3 Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles CCR5 TLR9 MYD88 PMC4450349__F1 Of flies, mice and men: Evolutionarily conserved tissue damage responses and aging MYC UNK PMC7471874__F11 Expression patterns of genes in IL-1 Signaling Pathway upon EI24 silencing TRAF6 ECSIT MYD88 MAP3K7IP1 PMC6041899__F7 Quercetin inhibits gastric cancer metastasis PAK1 LIMK1 MMP2 MMP9 PMC5369955__F9 Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway CTSL NEU1 TFEB LAMP2 PMC5675827__F7 Ingenuity Pathway Analysis (IPA) comparisons of the quantified readouts from RAD17 SRC HSPD1 TNFRSF10A DIABLO HTRA2 FADD TRIR PMC7920909__F2 SARS-CoV-2 Replication ALB ACE2 PMC4712384__F2 HCV replication cycle CLDN1 EGFR LDLR NPC1L1 EPHA2 CD81 PMC12240182__F1 Novel AR axis-directed therapy for the treatment of metastatic prostate cancer CYP11A1 CYP17A1 PMC3265067__F7 Phospholipid biosynthetic pathways PC PCYT2 PSD PEMT PMC4712384__F4 Evasion of innate immunity by HCV viral proteins TBK1 STAT1 SOCS3 STAT2 EIF2A TRAF3 IRF3 TYK2 MYD88 TLR3 MAVS PMC8479296__AF1 LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway LIN28B AGO2 PMC8465210__F10 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity APC GSK3B CCND1 PMC4672200__F3 Schematic of the proposed non-canonical Wnt signaling pathway induced in the ceca from experimental chickens with persistent colonization by Salmonella Enteritidis CAMK2A PMC2885424__F7 Transcriptional Regulation of the IGF Signaling Pathway by Amino Acids and Insulin-Like Growth Factors during Myogenesis in Atlantic Salmon IGF1R MAP4K3 IGFBP6 MTOR IRS1 PMC8465210__F15 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity HGF SRC CRK PMC5120243__F4 Network model for CTNNB1 SOX2 APC GSK3B MYC AXIN1 PMC6470689__F1 Proposed oncogenic mechanisms for Plk1 PLK1 MYC MDM2 TEX14 REST PTEN GTSE1 TOPORS SUZ12 PMC5527948__F1 Scheme depicting the major compartments of the endocytic pathway and selected endocytic proteins participating in the transmission of signaling to the nucleus, by affecting the transcription machinery and/or the chromatin‐remodeling factors TSG101 NUMB BIN1 VPS37A SSRP1 SNX1 ELL CITED2 PMC7471098__F7 Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer ATF4 TRIB3 PIERCE1 PMC10854812__F5 Function of CD133 protein FYN NRAS MDM2 GRB2 PTEN GRB7 PMC2795248__F3 Anti-inflammatory effects of EPAC in VECs SOCS3 RHO STAT3 PMC5980113__F6 Role of MICAL1 in breast cancer cell proliferation CDK4 MICAL1 PMC3777479__F2 Niclosamide targets the Wnt/Beta-catenin, Notch, and mTORC1 pathways APC GSK3B IRS1 PMC7265137__F3 Simplified picture illustrating some examples of how microorganisms promote the cancer TH IL1B STAT3 PMC4732855__F5 MAPK signaling pathway, determined using the Kyoto Encyclopedia of Genes and Genomes database CD14 IL1A MAP3K6 DAO DUSP9 FLNA EGFR FGFR2 MAX MAFK HEL-S-11 ECSIT PLA2G12B PLA2G10 POLI PMC10854812__F8 Models of both non-receptor tyrosine kinase- (NRTKs) and receptor tyrosine kinase-mediated signaling pathways in tumor progression and drug resistance FYN BRAF NRAS MDM2 GRB2 PTEN DEPTOR GRB7 STAT3 PMC10854812__F9 Downstream effectors of RTK-mediated pathways and their biological consequences BRAF GSK3B NRAS MDM2 GRB2 BCL2 PTEN DEPTOR SGK1 GRB7 PMC9687113__F2 DNA Damage and Repair in Idiopathic Pulmonary Fibrosis MSH6 SSB XPC XPA LIG1 MSH2 MUTYH PCNA PMS2 PMC3876931__F10 Differential regulation of the REGG–proteasome pathway by p53/TGFB signalling and mutant p53 in cancer cells SIN3A HDAC1 PMC11929932__F2 Immunomodulation on tumor immune microenvironment in acquired targeted therapy resistance and implication for immunotherapy resistance NCOR1 MUC4 CD163 CCR7 CD40 CDK4 PMC4685960__F3 Endosomal Toll-like Receptors in Clinically Overt and Silent Autoimmunity STAT1 TLR7 RO60 IL6 TNF PMC7464802__F3 MOMP-induced signaling activation in tumor cells CGAS PANX1 IL1B BAX DFNA5 PMC3332287__F2 Wnt signaling pathway participated in the activation of hepatic stellate cells ROCK2 NLK APC PROC LRP5 CER1 SMAD4 LRP6 SKP1 RBX1 PMC3734089__F1 Macrophages in pancreatic cancer initiation and progression ADM SOX9 STAT3 PMC11496054__F1 CGAS–STING pathway of cytosolic DNA sensing TBK1 CGAS IRF3 PMC7080988__F2 Computational Model of the Endothelial to Mesenchymal Transition FLI1 SNAI1 SMAD2 WNT7A FGF2 SMAD6 VEGFA SNAI2 NRARP GATA2 LEF1 TWIST1 NRP1 DLL4 ZEB2 SMAD1 STAT3 PMC6452569__F8 Parturition-specific signaling networks constructed using shortest paths and differential expression data BATF3 EIF4A1 MAPK9 BAD PTN SFN COPZ2 PGR MYC AHNAK CCDC6 UBE2D4 CRYZ RARA PIM1 IER3 NR1i1 PFN2 ACACB MT2A NFYC MDM2 SRC MAPK1 EIF4A3 MYO1G NAMPT PLAUR HEL-S-34 CD34 PRKX VHL CEBPA HRAS RXRA CASP3 EP300 PIM3 PRMT2 RELA SPHK1 MT1A HEL-S-93 OSM TRAF2 DCAF6 PNP PMC4835676__F5 An integrated model of the TLR signaling pathway modulated by the multifurcating motif of poeModules M14-M18 TBK1 TRAF3 TMCC3 TRAF6 NFKBIZ MYD88 RIPK2 SP100 CRKL BAZ2A RUSC2 STAT1 OAS2 IFNA2 DHRS3 ETV3 STAT2 IRF7 EHD1 IRF8 VCAN SPRED1 IRF3 SLAMF7 IFNB1 TNF NFKB1 ISG20 TGIF1 JAK1 REL CARHSP1 TIRAP TAB3 PMC11496054__F2 CGAS-STING signaling in female reproductive system diseases TBK1 CGAS HDAC3 POLE SETDB1 IRF3 USP35 TRIM28 PMC8065059__F4 Metabolic capabilities among distinct lineages within the Brockarchaeota phylum FTL ACD PMC8506768__F4 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis PIK3R1 PLCG1 BATF3 EGF IKBKG CHUK BATF2 CSNK2A2 PPP3CA PPP3CC MAPK3 MAPK14 MYD88 HIF1A MAP2K3 MAP2K6 TICAM1 STAT1 TLR4 PTPN11 PTPN6 IFNGR1 JUN CD3E CD3D PRKCQ NFATC1 HRAS PIK3R3 IKBKB NFKBIA RPS6KB1 NFKBIB PPP3R1 RPS6KB2 RELA ZAP70 PIK3CA JAK1 LAT TIRAP NFKBIE PMC3516830__F2 Interaction loop between the EGFR signaling pathway and miR-221/222 expression in the modulation of cellular processes BAD ZEB2 TIMP3 EGFR GRB2 TRPS1 PTEN MTOR PMC3070952__F1 Essential features of the PERK signaling temporal delay circuit ATF4 EIF2A ATF3 PMC10869077__F9 TNF signaling pathway SOCS3 TRAF3 CCL2 MMP3 CYLD JUNB PGAM5 CSF2 IRF-1 FOS TNF IL15 MMP14 VCAM1 TRAF1 CCL20 TNFAIP3 MLKL ITCH CHUK TRADD BAG4 VEGFD NOD2 CEBPB RIPK1 ATF4 CXCL6 JUN SELE MMP9 PTGS2 LIF RIPK3 CXCL2 IFNB1 IL6 MAP3K7IP1 IKBKB CASP3 BIRC2 NFKBIA LTA NFKB1 DAB2IP PIK3CA CSF1 TRAF2 FADD PMC7859322__F2 EMT-related lncRNA in the process of triple-negative breast cancer metastasis MMP7 ZEB2 PTCH1 PMC7743012__F4 Activation of cancer‐related signaling pathways TLR4 FOXA1 SUFU SMAD2 APC GSK3B SMAD4 CCND1 SMO PTEN MTOR PMC9315613__F3 Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies HP MDM2 PTEN MTOR PMC2945668__F1 TLR7/9 Signaling pathway leading to the production of proinflammatory cytokines and type I IFN TLR7 TLR9 IRF7 IRAK1 TRAF6 IRAK4 MYD88 PMC4123083__F8 The miR-203-mediated regulation network for skeletal muscle cell proliferation and differentiation MAML1 NOTCH3 MEF2C PMC9543876__F5 Pathway analysis using GRB2, a significantly connected and downregulated protein as the focus KIT WAS GAREM1 LRRK1 FRK GAB2 ERBB2 GRB2 PTPRE SHC1 ROS1 LAT ITCH PMC6296821__F1 Ex vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery IL3RA GRB2 PMC5005393__F1 Demonstration of how gene ontology annotations lead to understanding of biological networks SLC27A4 ACADL ACADVL LPL RXRG CPT2 PMC2042021__F6 Contrasting Infection Strategies in Generalist and Specialist Wasp Parasitoids of Drosophila melanogaster DDC TEP1 MYD88 TUB TRAF2 PMC9688210__F1 Targeting TET2 as a Therapeutic Approach for Angioimmunoblastic T Cell Lymphoma ARHA MTOR FOXO1 ICOS TET2 PMC2958340__F3 Canonical Wnt/Beta-catenin signaling NLK TGFBI PMC10341274__F2 Contrasting roles of AGRP and POMC neurons in glucose and lipid homeostasis POMC GHSR AgRP ARC LEPR PMC9496564__F2 Co-Stimulatory Receptor Signaling in CAR-T Cells PLCG1 ATF2 LCK TRAF1 GSK3B TRAF3 GRB2 CD80 MTOR TRAF2 LAT PMC4322984__F9 Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/Beta-catenin pathway ABCB1 PMC6365103__F1 Copper distribution pathways in a generalized mammalian cell ATP7B STEAP3 ATP7A ATOX1 HEL-S-44 CCS PMC2134904__F7 Schematic representation of the effects of RhoA/ROCK signaling pathway inhibition on membrane FasL expression and lymphocytes apoptosis HEL-S-62p ARHA PMC10312929__F8 Wnt signaling pathway ROCK2 BAMBI NLK INVS SIAH1 APC NOTUM SOST SMAD4 RYK PMC12139977__F6 Intersecting network analysis reveals interactions among genes involved in insulin secretion, cell cycle, and ER stress pathways ABCC3 CCNA2 PLK1 BIRC5 CDKN3 CENPF DTL RIMS2 TIMELESS EXOC6 CUZD1 STIL ANKS4B FOXG1 CDCA3 EZH2 TUBB FAM83D CENPE UHRF1 LMNA CDC45 SPAG5 HMGA2 CDC20 MCM2 KIF18B MC4R TUB TRIP13 FOXM1 INS GSG2 XBP1 PRC1 KNTC2 RRM2 SEC61B ESCO2 SPC25 TICRR GRB14 MYBL2 GADD45G CEP55 FBXO2 HCTP4 SNAP25 ISL1 CCNB2 SERINC3 JUND NR2E1 SKP2 PMC7346528__F1 Hedgehog signaling pathway PTCH2 IHH KIF7 SUFU PTCH1 GLI3 SHH DYRK1A PMC3770777__F5 Schematic description of the metabolic network proposed to link DFMO-mediated inhibition of polyamine synthesis to observed perturbations in the methionine cycle, trans-sulfuration pathway, purine synthesis/salvage and de novo thymidine production SHMT1 MTHFS PMC1857308__F9 The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones MTOR PMP22 PMC9456457__F1 Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and Asthma: New Potential Perspectives GRB2 PTEN MTOR PMC3366885__F1 Signaling pathways involved in head and neck cancer BAD SET ERBB2 ERBB3 EGFR MYC GRB2 SP1 TF STAT3 PMC5433721__F6 An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice ZNF183 NDUFB9 COX17 UCP1 NDUFAB1 NDUFA10 UQCRC2 UQCRFS1 SDHA UQCR11 PMC5518133__F2 Regulatory mechanisms of WBP2 in breast cancer EGFR CCND1 WBP2 PMC7824603__F1 An integrated model of the molecular pathway underlying light-mediated seed germination DAG1 RGL2 PIF1 PMC5884799__F7 MS TLR signalling pathway CS IFNA14 RELA SERPING1 CD40 IL6 CCL2 POR TNF IL1B ELL STAT3 PMC5884799__F8 Multiple sclerosis pathway CTSL EGR1 PTPRO LDLR IFNG PMC3893124__F1 Current and Future Therapies for Hepatitis C Virus Infection SCARB1 EGFR LDLR CD81 PMC11313706__F6 Regulatory mechanism of bone injuries induced by fluoride FGFR1 BMP2 MMP9 BCL2 BMP7 COL1A1 PMC5915419__F1 Molecular association of Wnt, MITF, TYR, and DCT GSK3B DCT PMC3492208__F3 Principal IFN-Alpha-modulated canonical pathway in MT-4 cells STAT1 STAT2 IRF9 PIAS1 GIP IFI35 IRF-1 PSMB8 IFNG BAX PMC5743859__F4 Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders NOD1 IRF7 TRAF3 STAT3 PMC1994616__F1 New molecularly targeted therapies for lung cancer EGF BRAF EGFR PTEN HRAS PMC9846474__F6 Unraveling the links between neurodegeneration and Epstein-Barr virus-mediated cell cycle dysregulation ATM MDM2 CDK4 ATR CDK6 AURKB PMC1994616__F2 New molecularly targeted therapies for lung cancer APC SMO ADAM10 PMC5362636__F2 Possible interplay between insulin-like growth factor (IGF)-1 and vascular endothelial growth factor (VEGF) receptor signaling pathways IGF1 RUNX2 BMP2 CD34 PMC7020744__F14 Role of RKI-1447 in liver cells and the TLR4/TBK1/IRF3 signaling pathway TBK1 ROCK2 TLR4 ROCK1 ARHA IRF3 PMC3845098__F1 N-glycoprotein biosynthesis in mammals DPM1 ALG1 ALG3 DPAGT1 ALG8 ALG13 ALG6 ALG10 ALG5 DPM2 DPM3 PMC3824607__F3 Crosstalk in TNFR1 signaling GADD45B TRADD TRAF2 FADD PMC3824607__F1 TNFAlpha-mediated transient IKK activation pathways TRADD MAP3K7IP1 TRAF2 PMC1904333__F2 Hepcidin regulation: ironing out the details HAMP SMAD4 HFE TFR2 STAT3 PMC5029683__F8 cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer MMP2 HEL-S-28 CDH2 MTOR PMC8844459__F1 Application of Animal Models in Interpreting Dry Eye Disease TNF PMC12133868__F2 MAPK signaling pathway TSC2 RET BAD BRAF MTOR PMC8968959__F1 Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration EGF GRB2 CBL PMC12133868__F3 Application and recent advances in conventional biomarkers for the prognosis of papillary thyroid carcinoma BRAF FOS MYC TERT PMC2764635__F3 New model of EGF activated ERK pathway: This is a schematic of our new model of the EGF activated ERK pathway which was developed from the original EGF model EGF EGFR RAF1 PMC6361568__F7 Cullin‐3 (CUL3) and KCTD10 regulate cell proliferation in SKBR‐3 cells EGF KCTD10 EGFR RAC1 RHOB PMC7182067__F1 The Regulation of Coagulation and Thrombosis HMGB1 ADAMTS13 RALA VWF RALB TRPM7 TF PMC2764635__F1 The EGF activated ERK pathway: This is a schematic of the EGF activated ERK pathway beginning at the level of EGF binding to EGFR and finishing at the level of ERK; see the text for more details on the features and functions of the pathway EGF EGFR GRB2 RAF1 CRK PMC6909948__F4 cAMP can regulate multidrug-resistance in lung cancer through the regulation of plenty of downstream effectors, which is participating in the cAMP signaling pathway such as the classical PKA and CREB or some other useful effectors ATM SIRT6 GSK3B CFTR PMC3681194__F1 Genes with mutations that cause monogenic, severe T-cell immunodeficiency in humans can be intrinsic to the thymic epithelium or to T cells RFX5 DNMT3B RAG2 RFXAP CBL TAPBP SP110 TAP2 ATM ZAP70 ADA JAK3 RFXANK PMC2764635__F7 Experimental results of Rap1 pathway knockout from Falco et al RET FRS2 GRB2 PMC2764635__F8 Comparison of growth factor receptor signalling: This figure shows a comparison of ERK signalling from the EGF and Insulin receptors EGF EGFR GRB2 RAF1 CRK MAL PMC4782155__F3 miR-146a-5p and miR-155-5p mechanism of action under normal conditions and early stages of inflammation (, , ) TLR4 IRAK1 TRAF6 PMC4367534__F2 Regulators of HR repair as potential therapeutic targets IGF1R PLK1 PLK3 BLM EGFR IRS1 BRCA1 CDC5L ATM BRCA2 RAD51 RBMX CDC2 ATR PMC6131304__F3 PCV2-induced apoptosis ATF4 ATF2 EIF2A PMC4367534__F1 DNA double strand break (DSBs) repair BLM RPA1 BRCA2 RAD50 RAD51 MRE11A DNA2 BRCA1 PMC8346253__F1 Distinct Signaling Pathways Distinguish in vivo From in vitro Growth in Murine Ovarian Follicle Activation and Maturation PTEN MTOR PMC7773602__F1 Autophagy and endolysosomal trafficking at the synapse RAB35 RAB26 APP PMC2133163__F6 Anchorage-dependent cell growth FOS CRK JUN PMC3643575__F4 Arachidonic acid metabolism pathway where the differential genes and metabolites of colorectal cancer were annotated DIO1 LIF PGC ACD PMC321455__F9 A model depicting the relationship between the p19Arf-p53 tumor suppressor pathway and the Rho GTPase signaling module in the regulation of cell proliferation and transformation PI3 ARHA RAC1 CDC42 PMC3561661__F1 Activation and function of PI3K/Akt signaling in CD8 T cell TSC2 LEF1 TSC1 APC MYC IL7R KLF2 PTEN RHEB PMC7093717__F8 Schematic diagram depicting how luteolin inhibits airway allergic responses JAK3 JAK1 GATA3 PMC7044323__F8 Gene expression profiles of p53 signaling pathway (hsa04115) in the bryostatin treated CD4+ T cells PERP IGF1 ATM RPRM MYC TP73 PTEN ATR PMC8826420__F7 Proposed molecular mechanisms of ANGPTL7 in CLAN formation in TM cells ARHA SP1 ANGPTL7 PMC6376273__F2 The pathogen‐derived molecules employed to evade the intracellular DNA sensing pathway TBK1 CGAS IRF3 AIM2 IFI16 PMC9166676__F4 Chemoresistance in cancer stem cells BMP1 DKK3 ABCC1 ABCG2 CDC42 ALDH2 BAX PMC4741068__F2 Reconstruction of the insulin/insulin-like growth factor 1 (IGF1)-like signalling (IIS) pathway of Haemonchus contortus PMC5744163__F1 Three types of autophagy and regulatory mechanisms ULK1 ATG12 ATG3 AMBRA1 BCL2 UVRAG MTOR ATG14 DKFZp686F0183 PMC8071872__F5 Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFNB STAT1 STAT2 IRF9 PMC11211608__F2 Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes KCTD13 ARHA MVP TAOK2 PMC9550700__F7 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model IL21R TH OMA1 NOD2 FOXP3 IFNG IL18 IFNGR1 IL1B GATA3 IL10 IL1A APC IL24 IL6 TNF IL23R tal-1 TBX21 IL-21 RORA IL18RAP TGFB1 IL18R1 STAT3 PMC9550700__F8 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model RELT TNLG2B OSM PMC12108277__F5 Summary schematic diagram of the mechanism by which miR-129a-3p negatively regulates the inflammatory response to G TLR4 MYD88 PMC8998186__F3 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response USP12 FYN CYLD OTUD7B LCK ZAP70 USP9X ITCH PMC8998186__F4 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response USP12 USP15 BCL10 USP9X MDM2 TRAF6 JUNB PELI1 ITCH PMC6315101__F1 Central metabolism in the S CS SART3 MDH2 PMC8490443__F4 BMP7 reduces the fibrocartilage chondrocyte phenotype ALPL MMP14 CEMIP MMP2 PLG TMEM119 BMP7 COL1A1 S100A4 PMC6065472__F7 Enriched pathways for radix tetrastigma hemsleyani flavonoid treated lung cancer cells EGF NRG3 BAD FLNA MYC MTOR NF1 BTC SRC ECSIT CD14 MOS FOS NRG2 SHE HBEGF NRG1 TNF MAP3K7IP1 CRK CBL NLK MAX GRB2 JUND BDNF TRAF2 NRG4 MEF2C PMC8800342__F1 Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress BAD MYC JUN PMC5494993__F6 Discovery of extremely halophilic, methyl-reducing euryarchaea provides insights into the evolutionary origin of methanogenesis FER CD2 PROC FES RPIA CYB POR ADK PMC2575803__F1 Most prominently involved biological pathways in OSCC STAT1 PIM1 STAT2 PIAS1 CRAT TYK2 MTOR PMC10971338__F1 General schemes of the NAD+ metabolic pathway NAPRT NAMPT HEL-S-90n NRK PMC4379025__F12 Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study AFP MTOR STAT3 PMC8348973__F2 Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease? TLR5 TNF PMC7643645__F6 Potential working model for the suppression of Asperolide A in bone metastatic breast cancer CTSK NFATC1 MTOR PMC7393488__F7 LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway LEF1 IRAK4 RNF121 MYD88 PMC9311450__F1 Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches BAD IGF1 BAX PMC3922885__F7 RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3 STAT3 PMC4739416__F1 JAK-STAT signaling contributes to the pathogenesis of MPNs EPO TPO MTOR PMC10963420__F1 Mechanism of astrocyte regulation of Lcn-2 NFKBIA NGFR EIF2A LCN2 NOX4 PMC8507001__F6 Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGFB/Smad3 pathway in chondrocytes ADAMTS5 SOX9 PMC11881707__F3 Interaction mechanism between intestinal flora and cAMP-PKA signaling pathway in neurological diseases CORT TPH1 CRH PMC3876023__F1 Suppression of regulatory B cells identified in human and animal IL10 BCR CD40 CD80 FOXP3 PMC2684867__F1 VHL Loss of Function and Its Impact on Oncogenic Signaling Networks in Clear Cell Renal Cell Carcinoma HGF LRP5 LRP6 PMC4149909__F2 Gaps in conventional treatment of heart failure include deranged Beta-AR signaling, distorted Ca2+ cycling with depletion of SR Ca2+ levels, diastolic dysfunction, and cell death PLN BAD CAD RYR2 ADRBK1 PMC4944499__F7 CRT-knockdown correlates with the modulation of p53 and MAPK pathways MAPK8 ATM MDM2 SERPINB5 MAP2K6 PMC10493031__F3 Schematic illustration of the CRC-derived exosome mechanisms for CRC metastasis CD9 HGF CD63 SMAD2 CD44 SMAD4 ARHA ADAM17 CD81 CXCL16 CXCR4 SRC BTG2 PMC10493031__F5 Schematic illustration of key molecular signaling pathways in metastasis MUC1 REG1B L1CAM HGF EGFR CD44 ZFP57 FBXW7 TET2 MACC1 NTF4 IGF1 CXCR4 PNMA5 TGM6 HOXC13 PMC11247318__F1 Action in lymphoma BTK LYN SYK TNF IFNG CD19 PMC12082737__F3 Canonical wnt signalling pathway (Kharaishvili et al APC WIF1 PMC2976306__F7 Changes in gene expression in central carbon metabolism (A) and ergosterol synthesis (B) PES1 HEL-S-26 ERG ENO1 ENO2 GLG1 GPD2 HEL60 MDH2 GPD1 HEL-S-68p PMC6605468__F5 Schematic model of morphogenic gradients controlling striatal development and involved in abnormal neurogenesis in Rarb−/− mice RARA RARB ASCL1 FGF3 MEIS1 DRD1 PMC10930964__F1 Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets RICTOR DEPTOR MLST8 PMC6887951__F4 FGFR pathway and dysregulation in cancer FRS2 GRB2 PMC5760356__F1 Kegg PI3K/Akt‐Signaling pathway with highlighted dysregulated mRNA and their associated seed‐region matched miRNA GNE BAD CHL1 BCR EBP MIA SYK PTEN RAC1 MTOR RBL2 PMC5102338__F6 Diagrammatic representation of possible mechanistic pathway for the induction of EGID TGFA PMC8502875__F5 Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1 PI3 GSK3B PMC7567953__F1 Sphingosine-1-phosphate (S1P) production and S1P/S1PR signaling pathways S1PR2 S1PR1 S1PR3 S1PR5 SPHK1 RHO S1PR4 SPNS2 SPHK2 PMC7567953__F2 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics HEL-S-62p S1PR2 RUNX2 SMAD4 S1PR1 ARHA SMAD1 DKFZp781O1323 PMC7882108__F8 VD3 ameliorated NM‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway NLRP3 IL16 SIRT3 PMC7567953__F3 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics S1PR2 GSK3B LRP5 PMC5661282__F9 Role of glycolysis in NPC self-renewal CITED1 IGF1 IGF2 BMP7 SIX2 FGF9 PMC7688453__F1 ERK and AKT pathway on lymphangiogenesis NF1 TSC2 VEGFC TSC1 MYC GRB2 VEGFA ATF1 RASA4 PTEN PROX1 PMC12095467__F8 125I particles inhibit the progression of cervical cancer by up-regulating the HSF1/PU SPI1 ATF4 SYK HSF1 XBP1 BRD4 PMC9691885__F2 Determinants regulating Toxoplasma gondii bradyzoite development HDAC3 IFNG PMC9691885__F1 Determinants regulating Toxoplasma gondii bradyzoite development ENO1 ENO2 CST1 PMC7649967__F2 Biglycan in the Skeleton RUNX2 BMP2 NFATC1 SMURF2 SOST LRP5 OSCAR LRP6 CALCR DKK1 SMURF1 SMAD1 PMC7662933__F3 ErbB receptors and their signaling pathways NRG3 ERBB4 FYN ERBB2 ERBB3 GRB2 NRG2 SRC NRG1 MTOR NRG4 PMC9560885__F2 Race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options EGFR CCND1 CDK4 CDK6 PMC133602__F6 The yeast glyoxylate bypass pathway and its possible connection with other predicted changes HEL-S-26 HEL60 HEL-S-32 COX5A PMC7169117__F6 Schematic illustration of the major KSHV factors and corresponding targets, by which KSHV modulates the TGF‐B signaling pathway SMAD2 THBS1 DKFZp781O1323 PMC8826489__F1 Circadian rhythms of 11-oxygenated C19 steroids and Δ5-steroid sulfates in healthy men HSD11B2 SULT2A1 HSD11B1 CYP11A1 HSD3B2 CYP17A1 PMC7169117__F7 Schematic illustration of the major HTLV‐1 proteins and corresponding targets, by which HTLV‐1 modulates the TGF‐B signaling pathway HBZ FOXP3 PMC7169117__F8 Schematic illustration of the major SARS‐CoV proteins and corresponding targets, by which the virus modulates the TGF‐B signaling pathway EGR1 STAT3 PMC3122057__F8 Proposed schematic of the roles of NIK and SMG1 in sensitive versus resistant cells in response to SMC and TNFA treatment SMG1 TNF TRAF2 FADD PMC7169117__F2 Schematic illustration of the major HCV proteins and corresponding targets, by which HCV modulates the TGF‐B signaling pathway SMURF2 PTEN PMC6526582__F1 Schematic representation of the three candidate genes and the four tag SNPs selected for this study in the IL-23 signalling pathway (SNPs rs3212227 and rs6887695 in IL-12B, SNP rs7857730 in JAK2, and SNP rs2293152 in STAT3) TYK2 IL12RB1 STAT3 PMC5607814__F1 AMIGO3 and LINGO-1 signaling in neurons.Both AMIGO3 and LINGO-1 are able to form a complex with NgR1 and P75/TROY (Mi et al., 2004; Ahmed et al., 2013) AMIGO3 RHO LINGO1 PMC7169117__F4 Schematic illustration of the major HPV proteins and corresponding targets, by which HPV modulates the TGF‐B signaling pathway SMAD2 SMAD4 SP1 PMC5607814__F2 Mechanisms of action for LINGO-1 and speculative AMIGO3 signaling in oligodendroglia.(A) LINGO-1 is able to bind to ErbB2 and prevent its translocation to the lipid rafts on oligodendroglial membranes AMIGO3 ERBB2 EGFR MTOR LINGO1 PMC7169117__F5 Schematic illustration of the major EBV proteins and corresponding targets, by which EBV modulates the TGF‐B signaling pathway PTPRK SMAD4 ATF3 ID1 PMC6015663__F4 SHP2 plays a key role in NSC proliferation, differentiation, and migration EGF CXCR4 GRB2 STAT3 PMC8744084__F2 Molecular regulation of brain metabolism underlying circadian epilepsy CRY1 NAMPT CRY2 RORB MTOR TSC2 TSC1 DBP TEF NFIL3 RORA SIRT1 PER2 HLF PMC3461607__F1 LPS/TLR-4 signaling pathway.Notes: LPS is delivered to CD14 by LBP, which in turn transfers LPS to TLR-4 CD14 TLR5 LBP MYD88 TLR1 IL1B PMC11792562__F4 Pathway map of differentially expressed genes involved in cytidine synthesis across the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways SDHC SDHA SDHB PMC11792562__F5 Pathway diagrams of differential metabolites related to the cytidine synthesis pathway in the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways SDHC SDHD SDHA SDHB PMC3434281__F6 Proposed model for attenuation of canonical TGFB SMAD and activation of non-canonical TGF-Beta-NFKB signaling pathways in HNSCC SMAD2 SMAD4 TGFB1 PMC8199989__F2 HECT-Type E3 Ligase in the Development of Cardiac Disease BIRC5 SIRT6 GSK3B LRP5 LRP6 TXNIP ATP2A2 ITCH PMC8527165__F2 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward AHR LAT2 CA3 PMC8527165__F3 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward AHR PMC8527165__F1 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward MPO PNMT DBH KIN MAPDA THRA PMC6016890__F3 Mechanisms behind low levels of hepcidin in liver disease HAMP HFE TFR2 PMC9268799__F5 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway CCNA2 MAPK8 MAPK10 CDK5 BCL2L1 PRKCA MAP2K1 PTPN1 LCK SRC PPP2CA CCND1 CDK5R1 JAK1 TERT PMC11592827__F13 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study BAD CD37 PTEN RAC1 EIF4E MTOR RHEB TSC2 TSC1 BCR MDM2 SYK EIF4B RBL2 CD19 PMC9247875__F6 Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells ANGPTL4 RPL21 MTOR RPL5 PRKDC PMC9268799__F2 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway CCNA2 CTSS MAPK8 MAPK10 CDK5 BCL2L1 CDK6 PRKCA MAP2K1 CDK2 PTPN1 LCK SRC EPHX2 PPP2CA CCND1 CDK4 CDC2 TERT PMC11592827__F14 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study UBC PLTP UCP1 AQP7 HEL-S-28 LPL CPT2 CYP7A1 PMC11730944__F5 Upregulated and downregulated gene expression profiles within distinct pathways CXCL13 EPOR AMH NODAL LIF CXCR4 INHA CCL21 LTB LEPR TIRAP XCL2 PMC12021630__F10 Molecular mechanisms of PGRN in diabetic nephropathy ULK1 HK2 PMC2806747__F1 TLR4 signaling pathway can be activated via GAG fragments requiring CD44 and MyD88 or through LPS, which requires MyD88, LBP, and CD14 CD14 LBP CD44 MYD88 IL1B PMC4391134__F7 Diagram of potential APOE4 -induced decrease in synapse-related proteins and disruption of NMDAR-mediated signaling, resulting in impaired learning and memory APOB FIG4 FLG BDNF APOE FIGN PMC6630988__F2 Herpesviruses modulate the JAK-STAT pathway STAT2 IRF9 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IRF-1 IFNLR1 PMC8741861__F7 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells FSHR RPS6 ADRBK1 PMC8741861__F8 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells GSK3B FSHR PTEN RPS6 MTOR FOXO1 RHEB PMC8741861__F5 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells EGFR CDK4 FSHR RPS6 PMC7369546__F3 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) CXCL1 MMP9 IL6 PMC4933276__F10 The proposed T835M-UNC5C- and V642I-APP-induced neuronal death-signaling pathways CNTFR APP RAC1 SH3BP5 CDC42 STAT3 PMC8040300__F7 Molecular mechanisms underly GSS against brain injury in tMCAO rats HEL-S-64p CD40 IL1B CD68 PMC7463618__F3 Lipids in regulating NLRP3 inflammasome NLRP3 TLR4 CPT1A NOX4 UCP2 FASN CD36 PMC7409684__F1 Pathological roles of ion channels and transporters in triple-negative breast cancer cells AQP3 IGF1R AQP1 MCU CFTR PMC8660813__F9 Kinetin-induced death of Vicia faba ssp. minor root cortex cells KIN PMC5912903__F1 PRPP riboswitches and their regulatory network GCA UACA GC PURA PURB PMC6020658__F3 Pathway mechanisms underlying CHMs improve lipid metabolism in liver cells PCSK9 ABCG5 LDLR NR1C1 HLF PMC3077584__F6 The effects of apoA-I on TNFA mRNA stabilization in LPS-stimulated macrophages TLR4 IL1B STAT3 PMC11313175__F2 RNA methylation in the development of muscle and fat in livestock GADD45B EBP JAK1 TG MEF2C STAT3 PMC10494518__F1 Insulin signaling pathway GRB2 MTOR CRK IRS1 CBL PMC7169117__F1 TGF‐B signaling pathway SMAD2 TGFBR1 SMAD4 TF PMC7520422__F9 Sphingosine-1-phosphate (S1P) acts in both S1PR dependent and independent pathways RIPK1 SPHK1 TRAF2 SPHK2 PMC4183579__F3 Role of MicroRNA Modulation in the InterferonA/Ribavirin Suppression of HIV-1 In Vivo PML RSAD2 STAT2 S100A2 EIF2AK2 DDB2 UNG MOV10 RFC1 ISG15 CHEK2 GBP1 MCM6 PERP UBAP2L PMC5824490__F6 Emerging Roles for SIRT5 in Metabolism and Cancer IMPACT HEL-75 HEL-S-44 PMC3175712__F1 (A–C) Schematics of Wnt signaling components in the absence of a Wnt signal (A), the presence of a Wnt signal (B), and the presence of a Wnt signal blocked by the displacement of Tcf7l2 by dnTcf7l2 (C) APC GSK3B GSK3A PMC8897435__F8 Model of this study CCND1 CTHRC1 PMC8227515__F1 Emerging Role of Amino Acids of the Brain Microenvironment in the Process of Metastasis Formation SHMT1 HEL-S-51e PHGDH PMC3218904__F1 Network pathway analysis of up-regulated genes in the gene category immune response HLA-E CES2 ANXA11 XPNPEP2 DGKD HERC3 CLEC4E KCNC3 PARP4 HLA-F TAPBP CBFA2T3 HNF4A MDFI CXCR4 ATN1 LILRA2 PTPN6 SBNO2 DNAJC14 SLC16A6 ENTPD1 PMC4718447__F1 Translational metabolomics in cancer research CPT1A TLK1 CA9 HEL-S-133P HK2 FASN PMC3218904__F2 Network pathway analysis of down-regulated genes in the gene category mitotic cell cycle MYC CENPF hCG_2044782 PRIM2 SMC1A POLE2 POLA1 MSH6 CDC27 DUT MSH2 GINS2 NEK1 CLPB DKFZp667O1614 TRUB2 CES2 FAM117A NEK4 CDC23 CDC25B BRCA2 KPNA2 GTSE1 SBNO2 PCNA INA MAP2 TTK ACHE ZNF175 SH3BGRL2 KNTC2 RRM2 GMNN YY2 INCENP HCTP4 PPP2R1B AURKA UBE2C HNF4A BCAT1 NCAPG SMC2 NEK2 HEL164 CETN3 RAN SMC4 ESPL1 PMC3775856__F10 Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation TFPI PLG CAST PMC3026473__F2 Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets BNIP3 IRS1 PMC7369546__F4 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) IL10 CXCL1 MMP9 CXCL2 IL6 TNF PMC9561999__F6 Good, the Bad and the New about Uric Acid in Cancer TSC2 TSC1 MTOR RHEB PMC3715494__F2 A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora DDI1 IGF1 SGK1 PMC9561999__F4 Good, the Bad and the New about Uric Acid in Cancer TSC2 HMGCR PMC8396560__F1 Macrophage Motility in Wound Healing Is Regulated by HIF-1A via S1P Signaling IL10 NLRP3 CCR2 ARHA IL6 SPHK1 CCL2 RAC1 MTOR PMC2697061__F2 Endoplasmic reticulum stress in disorders of myelinating cells ATF4 EIF2A XBP1 PMC9074313__F5 Functional roles of the circRNA/Wnt axis in cancer DKK1 ITCH PMC9074313__F3 Functional roles of the circRNA/Wnt axis in cancer DKK2 FRZB PMC5448626__F7 Possible schematic model of SNIPER(TACC3)‐induced death in cancer cells APC TACC3 XBP1 PMC9074313__F1 Functional roles of the circRNA/Wnt axis in cancer DAAM1 APC GSK3B RHO PMC3166778__F1 PI3K signalling pathway: The phosphatidylinositol 3-kinase (PI3K) signalling pathway begins with PI3K activation by receptor tyrosine kinases after growth factors or insulin stimulation TSC2 BAD MDM2 PTEN BAX PMC6477733__F3 Transcriptional reprogramming of the H-series strains H14, 20, 27, and 31 at 24 h post-induction of gene expression HIST1H1E TACC1 tal-1 FAT1 PMC8803618__F3 Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse? CXCL1 HP PTGER4 TGFB1 STAT3 PMC8946661__F8A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer CCNA2 RUNX2 SETD7 TRIM21 CCND1 CTNND1 GPR49 AXIN2 YY2 PMC4314529__F1 Mechanism of ICL repair in the FA pathway on collision of a replication fork with an ICL FAN1 SLX4 BRCA1 USP1 PMC5599801__F1 Modulating NAD + metabolism, from bench to bedside NAPRT HEL-S-90n NNMT PARP1 NRK PMC11084201__F18 Mechanisms of MPs’ impacts on the liver LEP IMPACT TG PMC3034644__F2 Self-regulation in Xenopus dorsal-ventral patterning.The pathway consists of a network of BMP-interacting proteins BMP2 BMP7 BMP4 PMC4795052__F4 Dysregulation of mTOR signaling pathway and mTOR in sleep phenotype of del 2q23.1 and SMS TSC2 RICTOR TSC1 ELF3 RHO EIF4E MTOR EIF4B SMS RHEB PMC3134268__F1 Schematic representation of the influence of photoperiod on deiodinase enzyme gene expression in the hypothalamus TSHB TSHR PMC5923376__F2 Hippo signaling pathway AMOT USP9X LATS1 SIAH2 LATS2 YOD1 NEDD4 ITCH PMC6828744__F1 Long noncoding RNA: TRIMming the viral load CGAS TANK TLR9 IRF7 TRAF3 IRF3 TRIM25 TLR3 TLR8 TLR7 AIM2 MAVS IFI16 PMC9003189__F2 Amino Acid-Related Metabolic Signature in Obese Children and Adolescents TSC2 TSC1 DEPTOR RHEB PMC8168947__F2 Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target PLK1 SUFU APC MYC SMO PMC4007928__F1 Key features of the phosphoinositide 3-kinase (PI3K) signaling pathway TSC2 BAD TSC1 MDM2 PTEN RHEB PMC8247573__F1 Arbuscular Mycorrhiza-Mediated Regulation of Polyamines and Aquaporins During Abiotic Stress: Deep Insights on the Recondite Players MYB DAO PMC7814318__F1 Wnt pathway APC ARHA CDC42 PMC3725758__F2 Neurofibromatosis Type 2 Protein, NF2: An uncoventional cell cycle regulator FOS NF2 CCND1 RAC1 EIF4E MTOR CDC42 PMC8310495__F1 Genetic Determinants of Paget’s Disease of Bone PML STMP1 CYLD NUP205 ZNF687 DCSTAMP TRAF6 OPTN PFN1 PMC8778376__F1 Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease AHR APC ASNS D2HGDH PMC9623991__F2 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer EGFR RAB31 RAC1 SPHK2 FLOT2 TNC FLOT1 PLD2 SAFB F2 LPL SRC PLEKHG2 ARF6 CDC42 PMC6156150__F7 Proposed network for AhR-Src-STAT3-IL-10 signaling pathway in inflammatory macrophages CD14 TLR4 AHR SRC MYD88 STAT3 PMC9119763__F7 Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway MFN1 MFN2 PMC9623991__F6 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer GRM3 TRPC5 HNRNPH1 SYT7 PANX1 SNAP23 ORAI1 STIM1 STAT3 PMC2789271__F1 Gene selection in the TGFß signaling pathway SMAD2 TGFBR1 SMAD6 TGFBR2 SMAD4 TGFBR3 SMAD1 TGFB1 TF DKFZp781O1323 PMC4727338__F2 Interaction between neurotrophins and VEGF NGF MTOR BDNF PMC3732412__F3 KEGG pathway map for genes in the three modules FST NODAL PITX2 TGFBR1 SMAD6 SMAD4 SKP1 ARHA THBS1 RBX1 LTBP1 IFNG PMC3245719__F1 Bioenergetic regulation of cellular physiology and gene expression PI3 GPX1 PTEN SIRT1 MCAT BAX PMC6674889__F9 The promotion of neuronal development by CD47 CD47 SRC CDC42 VAV2 PMC7022772__F6 KEGG proteasome pathway shows involvement of downregulated cytoplasmic POMP RPN2 ARC RP2 RPN1 IFNG PMC6883840__F1 The pathway for synthesis of PLP in E SP2 HEL-S-1a SP1 NR1A2 SP3 PMC3119520__F7 Predicted d-galactose network in Y. pestis SPR PMC12108420__F12 GnRH signaling pathway involves multiple molecular interactions regulating gonadotropin gene expression and secretion EGF GNRHR MMP2 GC EGFR GRB2 SRC RAF1 JUN CDC42 PMC8265195__F3 Drug-drug-gene Interactions as Mediators of Adverse Drug Reactions to Diclofenac and Statins: A Case Report and Literature Review ABCC3 CYP2C9 CYP2C19 CYP3A4 SLC22A7 CYP2C18 SLC22A11 SLC22A6 ABCG2 ABCC2 HEL-S-22 HEL-S-5 PMC3025764__F4 Metabolic regulation by FOXO1 in skeletal muscle TSC2 TSC1 LPL PDK4 MTOR RXRA CD36 PMC9649783__F7 MYBPC3 deficiency up-regulated NFKB/TGFB1/HIF-1A/aerobic glycolysis signaling cascade in cardiac fibroblasts, contributing to HCM myocardial fibrosis MYBPC3 CCL2 COL1A1 IL1B PMC3910345__F3 Molecular regulation of hepcidin by iron and inflammation BMP6 SMAD4 HFE IL6 IL6R SMAD1 DKFZp781O1323 TFR2 STAT3 PMC8161522__F3 Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models TH REN NPY GSK3B ARHA ENG NPAS4 TF TK1 DYRK1A PMC3893930__F2 Ewing’s Sarcoma: Overcoming the Therapeutic Plateau TSC2 FLI1 RICTOR TSC1 IGF1R IGF1 GRB2 MTOR RHEB PMC11914587__F7 Autophagy in neuronal death TBK1 SQSTM1 WDR41 SMCR8 C9orf72 OPTN PMC11914587__F3 Interactome of the molecular systems architecture of the NMJ microenvironment involved in ALS pathogenesis UBQLN2 SEMA3A C9orf72 RHO SARM1 FUS PMC4581211__F8 Proposed model of role of RNase L in crosstalk between autophagy and apoptosis RNASEL OAS1 BCL2 BAX PMC6814203__F2 STING pathway activation initiates the anti-tumor immune response BATF3 CXCL10 CXCL9 PMC6814203__F1 STING pathway signaling and regulation IFIT3 TBK1 CGAS ENPP1 ULK1 TRAF3 MUL1 SENP2 GSDMD RNF5 AMFR TTLL6 TTLL4 ATG9A HMGB2 AIM2 TFAM IFI16 HMGB1 TRIM41 IRF3 ZDHHC1 TRIM29 TRIM14 INSIG1 TRIM38 RNF26 TRIM32 TRIM56 TREX1 STIM1 PMC8470786__F2 Interaction between microRNAs and the Wnt/Beta-Catenin Signaling Pathway in Osteoarthritis FOXC1 NLK APC GSK3B SOX9 PMC10372241__F1 New insights into regulatory cell death and acute pancreatitis APAF1 MCL1 FADD BAX PMC12189910__F8 Schematic figure depicting the potential role of LPS on endometrial receptivity in sheep TLR4 ITGB3 LIF PMC8534127__F5 Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q IKZF1 GPR68 CAST IL2RA RCAN1 DDB1 IKZF3 CUL4A IRF4 CRBN PMC6592288__F5 Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications NF1 CDK4 PTEN RHEB PMC5423480__F3 Induction of an innate immune response to Ad-based vectors STAT1 TLR4 TLR9 STAT2 IRF9 MYD88 TLR1 NOD2 PMC6221654__F5 Gene regulation network of 4 gene signature models MYB ETV4 COL1A1 CEBPB FOXP3 STAT1 NF1 RARB TBP LIMCH1 PAX5 CKAP4 ETS2 JUN NFATC1 INTS8 NR3C1 CEBPA OTOF TCF2 GATA2 RXRA ITGAM NFATC2 EDNRB TIMP1 THBS2 VCAM1 STAT4 YY1 HOXD9 SLC40A1 TCF4 PMC4067122__F6 Schematic drawing of the Hippo pathway in human EC YAP1 CCND1 LATS2 PMC5070033__F1 Molecular signaling events of brain-derived neurotrophic factor-mitogen-activated protein kinase pathway and depression FRS2 GRB2 PYY BDNF PMC6482021__F2 Thyroid enlargement in patients with homozygous INSR mutation IGF1 INSR PMC7327477__F7 Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage RPL11 RPL5 SKP2 PMC8067938__F1 Hippo signaling: bridging the gap between cancer and neurodegenerative disorders WWC1 AREG VGLL4 MYC AJUBA SCRIB RASSF4 LATS2 RASSF1 ZYX NF2 RASSF2 WWC2 RASSF6 FRMD6 PMC5241894__F7 Insulin-like growth factor receptor 1 (IGF-1R)– and mammalian target of rapamycin (mTOR)–induced alterations upon the canonical IGF-1R signaling cascade, mitogen-activated protein kinase (MAPK) and receptor tyrosine kinase RTKs in Ewing sarcoma (ES) IGF2 EEF2 PIR PTEN EIF4E MTOR IRS1 RHEB TSC2 RICTOR TSC1 IGF1 GRB2 IGFBP2 PMC3488811__F1 Simplified diagram of choline-related one-carbon metabolism PC MTHFD1 PEMT PMC4431853__F7 House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 TLR4 S100A8 LYN S100A9 PMC5597960__F7 Systemic lupus erythematosus (SLE)-activated platelets induce endothelial cell activation via an interleukin-1B (IL-1B) pathway LPA IL1B PMC7230029__F1 Chromothripsis and telomere crisis: engines of genome instability TBK1 CGAS TREX1 IRF3 PMC10242177__F1 Myostatin: a potential therapeutic target for metabolic syndrome SMAD2 SMAD4 MSTN PMC9704363__F6 Noncoding RNAs in cancer lipid metabolism SQLE FACL4 ACSL1 ACLY HMGCR FASN GLS PMC3574928__F1 De novo purine biosynthetic pathway in humans PAICS HEL-S-70p ASL PMC7937683__F8 Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activation EGF DSG2 EGFR PMC4287361__F1 Epstein-Barr virus Associated B-cell lymphomas: Pathogenesis and Clinical Outcomes RUNX3 TRADD CDK2 LYN MDM2 CCND1 SYK CDK6 PMC9576796__F5 Proposed metabolic pathway for anaerobic propane oxidation coupled to nitrate reduction PCCB FADD PMC9704363__F5 Noncoding RNAs in cancer lipid metabolism RARA ACSL1 MTOR NR1C1 FASN PMC3827622__F5 Proposed genetic networks of osseointegration EPO RUNX2 BMP2 NPAS2 PER2 SOX9 PMC4646252__F1 Interaction between SAMHD1 and deoxyguanosine kinase activities in the regulation of mitochondrial dGTP PNP PMC3338780__F8 Receptor Tyrosine Kinases Activate Canonical WNT/Beta-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation APC AXIN1 LRP6 PMC8234227__F4 Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers ULK1 MTOR TRAF2 XBP1 FADD BAX PMC11941373__F7 Impact of DNA damage pathways on improving anticancer efficiency and reducing systemic drug resistance ATM RAD51 BRCA1 PMC8163534__F8 Pharmacological Mechanisms Underlying the Therapeutic Effects of Danhong Injection on Cerebral Ischemia PTEN PMC7981155__F2 WNT5a in Colorectal Cancer: Research Progress and Challenges APC LRP5 LRP6 ROR2 RHO PMC5393392__F3 Protein interactions during the flavivirus life cycle elucidated by MS-based proteomics TSG101 ME1 RAP2B PREB SRFBP1 NUP98 HRAS GBF1 APOE PMC6863093__F4 HVEM behaves as bidirectional switch based on environmental signals: LTA CD160 BTLA CSA2 TRAF2 PMC4569046__F5 Microbial subversion of neutrophil function leads to periodontal inflammation ARHA MYD88 TLR1 SMURF1 MAL PMC6863093__F2 PD-1 exerts intrinsic suppression of T cell activity proximal to the TCR: APC ZAP70 PMC6379961__F1 Overview of PI3K/AKT/mTOR signaling pathway PTEN MTOR PMC7582747__F3 Proposed regulation of PlGF and TGFB in early diabetic retinopathy ANGPT1 PIGF SMAD2 EDN2 TGFBR2 PECAM1 PRDX3 PMC8913403__F3 Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review CAD BAX PMC6425641__F1 Schematic presentation of strategy for SLA-PEB biosynthesis in E SLA EMD PMC4098112__F1 Regulation of muscle mass IGF1 SMAD2 SMAD4 IRS1 PMC5110029__F1 Type I interferon signaling and type I interferonopathies as currently assigned CGAS STAT2 IRF9 RNASEH2C RNASEH2B IRF3 IFNAR2 RNASEH2A IFNAR1 USP18 STAT1 ISG15 POLA1 TREX1 TYK2 ACP5 JAK1 PSMB8 MAVS PMC6010520__F9 Proposed model for illustrating the essential roles of DNA sensors in recognition and innate interferons (IFNs) production during ectromelia virus (ECTV) infection TBK1 CGAS TLR9 IRF7 DDX41 IRF3 PMC3051001__F1 RIP1 COMES BACK TO LIFE AS A CELL DEATH REGULATOR IN TNFR1 SIGALING CD40 TNF TRAF2 PMC9343696__F1 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment E2F4 E2F7 SHE CDK4 SIAH2 CDK6 STAT3 PMC6889822__F4 Multiplexed Proteome Profiling of Carbon Source Perturbations in Two Yeast Species with SL-SP3-TMT HEL-S-26 ACO2 HEL60 PMC7294914__F7 Proposed mechanism by which melatonin protects human renal proximal tubule epithelial cells against high glucose-induced fibrosis through the upregulation of PrPC CDH11 SMAD2 PMC10917537__F1 Fundamental ferroptosis-related intracellular pathways and mitochondrial regulation GPX4 FACL4 GPT GLS2 VDAC3 PMC3216277__F5 Pathways underlying the absorption of cholesterol from the intestinal lumen and its delivery to the liver ABCG8 ABCG5 NPC1L1 ACAT2 PMC8124548__F3 Inhibitors of Chemoresistance Pathways in Combination with Ara-C to Overcome Multidrug Resistance in AML. A Mini Review BAD MEI1 MTOR BAX PMC3216277__F1 Within the intestinal lumen, the micellar solubilization of sterols facilitates movement through the diffusion barrier overlying the surface of the absorptive cells ABCG8 ABCG5 TG MTTP HMGCR ACAT2 HEL-S-5 PMC4632709__F3 Single network includes most splice regulatory genes dysregulated in MS MED10 MYC PTEN MED31 POLR2J EIF3G TRFP SCAF11 CCNB1 PCBP1 HNRNPA2B1 SPEN CSTF3 MED4 MED19 NFE2L2 MBNL1 MED9 YTHDC1 MED18 MED22 DDX39B TRA2B HNRNPH1 CD24 PMC3549263__F3 Low-dose radiation responsive genes linked to carcinogenesis SP1 IRS1 PCNA PMC2872667__F4 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling SPARC EGR1 PTN PTPRK POSTN CYTL1 CLU SOX9 PLN DCN HSPG2 MMP2 TIMP3 PMC8356007__F7 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research FER KIT BTK GCK HRAS SELE INSR PMC8313238__F5 CD38 in the age of COVID-19: a medical perspective NLRP3 TLR7 TRPM2 CCL2 MYD88 TNF IL1B TMPRSS2 PMC2872667__F3 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling PTN RUNX2 EGFR ADAM12 DOCK1 NCAM1 BGLAP FGFR2 FGFR1 CXCR4 FZD7 CAV2 CDH2 MUC20 PMC7591852__F3 Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone ME1 HEL-S-30 DLD PFKM HEL-S-128m HEL-S-32 PCSK1N MDH2 HEL-S-2a FH ACO2 PRDX5 HEL-S-133P DLAT PMC4811921__F3 Latency-associated nuclear antigen-mediated deregulation of cell cycle ATM CDK2 MDM2 CDK4 CDC2 CDC25B ATR ID1 BRD2 BRD4 PMC8568584__F7 Direct modulation of hepatocyte hepcidin signaling by iron BMP6 NOX4 SMAD1 DKFZp781O1323 STAT3 PMC10758887__F16 Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives APC LRP5 LRP6 DKK1 PMC11021710__F3 Cell cycle signaling pathway (A) and cellular senescence (B) CCNA2 E2F4 PLK1 HEL-S-1 SMAD2 GSK3B MYC WAPAL SMAD4 RB1 TFDP1 CDKN2A CDK6 MTBP CCNE1 SMC1A DDX11 WEE1 MDM2 CDC27 RAD21 ESCO1 SGOL1 GADD45A HRAS FOXO1 AURKB CDC45 RHEB CDC20 MCM2 CDC6 CDK2 PPP2CA ATR CDT1 TGFB1 PCNA TRIP13 BTRC SFN TTK CCNH MTOR DBF4 CDK7 FZR1 ATM KNTC2 CCNB1 CCND1 CDC2 NIPBL PRKDC PTTG1 RBL1 TICRR MAU2 MYBL2 FOXO3A MAD2L1 SKP1 STAG1 CHEK1 GATA4 BUB1B SMC3 ORC1L KNL1 SKP2 ESPL1 PMC1458968__F4 Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin TEF CDH2 PMC4447079__F2 Illustration of protein modification by the ubiquitin proteasome system MVD NEDD8 SUMO1 PMC4710869__F1 Simplified schematic summarizing the BMP signalling pathway and genes that have to date been shown to be mutated in PAH and demonstrating that many of these mutations encode protein involved in BMP signalling BMP10 KCNK3 PMC2666388__F1 DHA, NPD1, and BAPP-derived AB peptide signaling circuits in homeostatic aging and in AD SORL1 ADAM10 APOE HEL-S-5 PMC11580055__F7 Mechanism of EE improving secondary brain injury after TBI through the TLR2/NFKB/MMP9 pathway MMP9 TNF PMC5412475__F1 Schematic presentation of the postsynaptic structure and function on the basis of acetylcholine receptor clustering centered on agrin- and Wnt-signalings, trans-synaptic communication and synaptic stabilization MUSK LRP4 NRG1 RHO ERBIN RAC1 ACHE CRK CRKL PMC6502894__F1 Diagram showing the main paracrine and dichotomic autocrine functions of the IL-6/JAK/STAT3 pathway in the pathophysiology of skeletal muscle FAP STAT3 DMD PMC6939830__F1 S1P-S1P receptor signaling system MFSD2B RHO SPNS2 PMC7068780__F4 Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis APOM IL27 MYC HLA-C PMC5601165__F2 Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions KIT MOS PDGFRA MYC SRC MTOR STAT3 PMC11604675__F1 Fusobacterium nucleatum facilitates the metastasis of CRC via modulating the expression of FadA-Wnt/catenin signaling cascade and NFKB/TLR4/MYD88 signaling pathway TLR4 CCL20 CCND1 MYD88 PMC8465622__F1 Repurposing Small Molecules to Target PPARG as New Therapies for Peripheral Nerve Injuries CD44 ARHA GAP43 STAT3 PMC7279384__F2 Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation POMC GHSR AgRP STAT3 PMC4964491__F3 Flii involvement in inflammation TLR4 LRRFIP2 TRAF6 MYD88 FLII PMC7943556__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway IGF1R EGFR PTEN PMC9604797__F2 Carotenoids from Marine Microalgae as Antimelanoma Agents MDM2 CDK4 PTEN RB1 CDK6 PMC9604797__F3 Carotenoids from Marine Microalgae as Antimelanoma Agents GSK3B CCND1 CDK4 PTEN CDK6 PMC2631308__F1 Insulin resistance TG IRS1 FOXO1 INSR PMC3252731__F1 TLR4 signaling pathway is highly regulated TBK1 TLR4 IRAK1 TRAF6 IRF3 IRAK4 MYD88 PMC4106326__F15 Model depicting how PPARB/D promotes H-RAS-induced cellular senescence, whereas ER stress attenuates H-RAS-induced cellular senescence HEL-S-28 MDM2 MTOR PDPK1 PMC5294958__F1 TGFB/Smad4 signaling pathway SMAD2 SMAD6 SMAD4 PMC7767754__F6 DDR pathway [, , ]: The DNA damage and response pathway: The figure depicts the causative agents and plausible DNA damage repair pathways ATM SSB PARG ATR H2AX PMC7521960__F2 COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis IKBKG CHUK NGF TLR9 IRAK1 TRAF3 TRAF6 MYD88 TLR8 TLR7 TLR4 BCL10 BCR ATM BASH CYLD CCL13 CD40LG IL1B CD14 PTGS2 LTB HAO2 CCL4 IRF3 TNLG7C TLR3 NFKBIA EDAR LTA NFKB2 TRAF5 VCAM1 NFKB1 LCK LBP LYN ZAP70 CD40 CXCL12 TRAF2 LTBR LAT TIRAP PMC4316787__F4 Fourth-ranked enriched canonical pathway identified using IPA at 2 hpi – the CD40 signaling pathway MAPKAPK2 LTA FCER2 TRAF5 TRAF1 ATF1 TRAF6 JAK3 TRAF2 STAT3 PMC4316787__F3 Top-ranked enriched canonical pathway identified using IPA at 2 hpi – the IL-10 signaling pathway SOCS3 LBP TYK2 JAK1 SP1 HMOX1 STAT3 PMC7543045__F9 Schematic model showing G10 activation of the NLRP3 inflammasome in porcine cells TBK1 NLRP3 IL18 IRF3 IL1B PMC6938671__F1 Two predominant DSB repair pathways in mammalian cells GEN1 BLM SLX4 EME1 TOP3A RMI2 BRCA1 WRN BRCA2 RAD52 RAD51 PNKP DNA2 PMC11688383__F1 ER stress and activation of the UPR signaling pathways ATF4 XBP1 PMC8275894__F1 Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes IL2 AIRE IL2RA PTPN22 FOXP3 PMC11688383__F2 Insults to airway epithelial cells, their impact on UPR and the consequences of UPR activation ATF4 XBP1 PMC11688383__F3 Inflammatory signaling pathway regulated by UPR ATF4 TXNIP ATF5 TRAF2 PMC7573563__F1 Innate immune response during ADE and non-ADE dengue infection TLR7 TANK SOCS3 RIGI TLR3 PMC11688383__F5 ER stress-mediated autophagy and the possible mechanisms ULK1 ATG12 ATF4 ATG101 UVRAG TRAF2 DKFZp686F0183 PMC4980033__F3 Modelling the Structure and Dynamics of Biological Pathways POM121 NUP214 TPR NDC1 PMC8192490__F3 miR-940 is a new biomarker with tumor diagnostic and prognostic value MMP7 CCND1 CDK4 STAT3 BAX PMC2642890__F2 Posttranscriptional regulation of gene networks by GREs MYB BAD PLK1 ROCK1 MYC CCNH SMAD4 XBP1 CDK7 RARA SIAH1 BCL10 AHR WEE1 ATM APAF1 NFYC MDM2 SIN3A BTG2 ETS2 CAD JUN IRF4 SGK1 BAX UBE3A RUNX1 ING1 NR3C2 DNAJB9 GADD45A TNF DIABLO HSF2 HTRA2 FOXO1 BCL6 GTF2E1 EGR2 CDK2 PPM1D TRAF1 PPP2CA ATR PMC11814165__F2 Illustrating of the binding mechanisms of berberine with PLA2, MD2, BACE1, AB1-42, TGFBR1, and JAK2 in human cells BACE1 TLR4 COX1 TGFBR1 APP MYD88 PMC6558179__F5 Underlying mechanism of SSa on T cell-mediated immune surveillance in breast cancer STAT4 TYK2 PMC5702962__F1 Structure of (A) HGF and (B) Met HGF GRB2 RAC1 RAF1 MTOR CDC42 STAT3 PMC8616147__F6 RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERA)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2 FOXM1 YAP1 PMC10937431__F4 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced PANoptosis and ferroptosis GPX4 NLRC4 LPCAT3 TRADD FACL4 KEAP1 RIPK3 TNF ZBP1 GSDMD RIPK1 TRAF5 HEL-S-64p TRAF2 CASP8 FADD MLKL TAB3 DFNA5 PMC5303000__F2 Role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia NDRG2 NDRG3 MYC VHL HK2 NDRG4 GLS PMC4323240__F7 Macrophage Activities in Proliferation, Lysosome, and Phagosome by the Nonspecific Immunostimulator, Mica PI3 MALL CDK2 CA14 SMAD4 PCNA MYT1 PMC6803663__F1 Flow diagram illustrating the molecular methodology and frequency results of CRC cases diagnosed between 2011–2012 MSH6 MSH2 PMS2 PMC3991965__F2 Prostaglandin Analogues on Aqueous Humor Outflow Pathways EGFR RHO TF PMC9460961__F2 Combination strategies to optimize the efficacy of chimeric antigen receptor T cell therapy in haematological malignancies ITK BTK BCR CD80 TIGIT MTOR CD3G PMC7339783__F9 Graphic summary of the findings of the present study HMGB1 TLR4 IL1B PMC10937431__F3 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced autophagy ULK1 ATG16L1 ATG12 ATG3 AMBRA1 MTOR ATG14 DKFZp686F0183 GABARAP PMC8508861__F3 Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer TRADD FADD BAX PMC4433804__F1 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision LRAT RPE65 RDH5 PMC9277309__F5 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD SMYD2 PKD1 MTOR SIRT1 PMC7728437__F1 On-Off DSGCs in Gabra2 cKO mice show reduced direction selectivity and reduced null-direction inhibition in the noisy background WAC GABRA2 PMC9277309__F3 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD BCL2 TNF PMC6927547__F1 Key anti-obesity strategies and pharmacological agents PRDM16 RBPJ UCP1 ADRB3 STAT3 PMC3879631__F6 Model for potential roles of SIRT7 in ribosome biogenesis SIRT7 MTOR PMC5008583__F3 KEGG in Graphviz view of T-cell receptor signaling pathways on a canonical signaling pathway with gene methylation chip data PLCG1 IKBKG CHUK PPP3CA MAPK14 NCK1 ITK LCP2 FYN BCL10 CD40LG ICOS CD3E FOS VAV1 ARHA CTLA4 TG IKBKB NFKBIA PAK1 NFATC2 MAP2K1 NFKB1 PTPRO LCK ZAP70 GRB2 PIK3CA MAP3K14 MAP3K8 RAF1 SOS1 LAT PDCD1 PMC4440424__F2 Class I PI3K pathway TSC2 RICTOR BAD TSC1 MDM2 GRB2 PTEN MTOR FOXO1 PDPK1 RHEB PMC5008583__F4 KEGG in Graphviz view of Jak–STAT signaling pathways on a canonical signaling pathway with gene methylation chip data STAT2 IRF9 MYC SPRED1 SPRY1 BCL2L1 CCND3 PIM1 CREBBP CISH PTPN1 CNTFR GRB2 PIK3CA STAM2 JAK3 PTPN6 SOS1 SOCS1 PMC4214394__F1 Activation of mammalian target of rapamycin occurs through a complex signaling cascade TSC2 EEF2K RICTOR TSC1 EEF2 MTOR BDNF RHEB PMC8797727__F3 p16 a biomarker of aging and tolerance for cancer therapy CDKN2B MDM2 CDK4 CDK6 PMC5343994__F1 Mutation in the von Hippel–Lindau gene (VHL) induces loss (red ×: HIF-2a is no longer inhibited) of the regulatory tumour suppressor p-VHL and catalyses the “von Hippel–Lindau-hypoxia-inducible factor” VHL-HIF pathway VHL TPR TGFA PMC7074405__F1 Curcumin exerts various effects on the malignant activities of tumor cells HGF CCND1 STAT3 PMC8709963__F9 Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway RETN PGM3 PHKA1 PDK2 PFKL PDK4 TG IGFBP5 HEL-S-68p PMC5192396__F2 Inhibition of ribonuclease L (RNase L) activation by picornavirus proteins RNASEL G3BP2 IRF7 IRF3 MAVS PMC5876656__F1 The Hippo signaling pathway is composed of neurofibromin 2 (NF2), mammalian STE20-like protein kinase 1/2 (Mst1/2) and large tumor suppressor 1/2 (Lats1/2) NF2 LATS1 LATS2 PMC3285398__F1 Toll-like Receptors (TLRs) recognize specialized structural motifs on the microbes known as pathogen-associated molecular patterns (PAMPs) TBK1 TLR5 TLR9 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC3285398__F2 Proposed mechanisms of interaction between TLRs and MUCs: I ERBB2 GSK3B TRAF6 IRAK4 PMC4625546__F1 Is Retinol Binding Protein 4 a Link Between Adiposity and Cancer? LRAT STAT3 PMC7099488__F1 Bile acid synthesis in the liver CYP27A1 CH25H GCA CYP46A1 CYP8B1 CYP7B1 BAAT CYP7A1 PMC7296156__F3 Biological properties of cmvIL10 in myeloid progenitors (during lytic infection) CD14 HLA-G CXCR4 STAT3 PMC2650409__F6 c-Src Regulates Akt Signaling in Response to Ghrelin via Beta-Arrestin Signaling-Independent and -Dependent Mechanisms RICTOR REST MTOR MLST8 PMC5879999__F1 Metabolic interventions suggested by OptForce for increasing production of octanoic acid (C8) in E HACD3 CIT FADD MAL PMC7016617__F2 Signaling pathways modulated by SCD1 activity and levels BAD ATF4 APC GSK3B NOX4 BAX PMC9179486__F1 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated HEL-S-90n KYNU KMO AFMID PMC4048950__F10 Redox control of p53 in the transcriptional regulation of TGFB1 target genes through SMAD cooperativity ATM USF2 SMAD2 EGFR SMAD4 ATR PMC9179486__F3 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated KYNU KMO AFMID ID1 PMC2724105__F2 The postreceptor insulin signaling pathway and insulin-independent 5′-adenosine monophosphate kinase (AMPK) beginning from insulin binding to its receptor to GLUT4 translocation via vesicular trafficking PDK2 INS PTEN PMC7407683__F5 FSH and ovarian cancer SOX2 CCND1 TRPC3 PTEN HIF1A PMC9495820__F8 Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells ANXA1 FPR2 CAD GLS PMC10887103__F5 Defective PI3K/Akt pathway in T2DM results in insulin resistance and the activation of the pro-inflammatory, pro-apoptotic inhibition of eNOS and glycogen production PLN MTOR RYR2 PMC7407683__F1 FSHR is expressed in multiple organs related to metabolic diseases and FSH/FSHR participates in the regulation of cellular activities and metabolic processes RARB DGAT2 UCP1 LPL LDLR FSHR RDH10 MTOR PMC7407683__F2 FSH and obesity RARB DGAT2 LPL FSHR RDH10 PMC3427269__F1 AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway SRC IL6 JAK1 STAT3 PMC6515458__F3 Protein–protein interaction (PPI) network in muscle wasting in cancer cachexia TUBA4A SOCS3 PCK1 HSP90AB1 HSD11B1 FST MMP3 HGS GABARAPL1 JUNB C1S PNPLA2 NR3C1 MSTN FOXO1 TSC2 TUBA1A PAK1 HP TRIM63 FBXO32 NUDC BNIP3 CXCL12 MYH8 MEF2C UCP3 ANGPTL7 STAT3 PMC6515458__F1 MicroRNA-regulated networks in muscle wasting during cancer cachexia based on meta-analysis data SOCS3 TRIM63 FBXO32 NR3C1 GABARAPL1 MSTN JUNB CXCL12 BNIP3 MEF2C FOXO1 STAT3 PMC2694962__F1 Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis RFC1 HEL-S-61p MTR MTRR PMC9333902__F1 Immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review) IRF3 TRIM25 TLR3 PMC8799426__F3 Trend of CRISPR-Based Technologies in COVID-19 Disease: Beyond Genome Editing ACE2 PMC9343696__F2 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment BCL10 TRAF6 PMC11876862__F1 Mechanisms of protein degradation and synthesis in muscles PINK1 IGF1 ATG12 SMAD2 SMAD4 MSTN BNIP3 MTOR GDF11 SMAD1 DKFZp781O1323 STAT3 PMC7540572__F1 Tricin biosynthetic pathway from the key pathway‐branching intermediate, p‐coumaroyl‐CoA, with generic enzymes in grasses noted in green (Lam et al., ; Eloy et al., ), and in red are those from Medicago sativa (Ms) and M STS F3 CAD PMC7846970__F3 ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease ROCK2 MAS1 HEL-S-8a ARHA PMC3141233__F7 A model for the role of FANCD2 in Ad replication-dependent recombination FANCD2 BLM ATR PMC3322146__F8 Role of miR-148a in Hepatitis B Associated Hepatocellular Carcinoma PTEN PMC4996367__F1 Immune cell-derived complement on T cell immune responses HEL-S-62p NLRP3 CD46 APC CD40 PMC4730276__F2 EGFR function in hepatocytes and Kupffer cells during hepatocellular carcinoma (HCC) formation EGFR IL6 MYD88 IL6R ADAM17 PMC9453478__F1 Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability REV1 PALB2 FANCD2 RPA1 SLX4 FAAP24 FANCM RAD51C PMC8888452__F1 Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies MAML1 RBPJ EP300 SMAD2 APC SMAD4 TNF MTOR PMC6381758__F7 Modified KEGG map of the JNK and p38 MAP kinase signaling pathway showing transcriptional changes TRADD MAP2K4 MAP3K11 ATF2 RPS6KA4 HSPA2 TGFBR1 TGFBR2 MAP2K3 MAP2K6 MAP4K1 TNFSF6 MAP4K3 JUN PTPN5 MAPKAPK2 DUSP4 MAP3K1 NFATC1 RPS6KA5 MAP3K5 CDC25B TNF HEL-S-31 NFATC3 DDIT3 HEL-S-102 DUSP5 MAX TNFRSF1A MAPKAPK3 TRAF2 MEF2C DUSP3 TGFB1 HEL-S-72p PMC9023592__F1 Product of AS of pre-mRNA: lncRNA MAX IFITM1 IFNG IFI6 IFIT1 PMC8377458__F2 Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia KCNQ2 COX2 KCNQ3 PMC8639599__F1 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia MSC NOTCH1 CDH2 THPO MPL CCL3 PMC7432306__F4 Reconstructed metabolic map of xanthan biosynthesis in Xpm PPIE TNLG7C RPE PPIC PMC8639599__F2 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia CXCR4 MSC CD34 CD44 EMCN CXCL12 PMC3956502__F4 Mechanisms underlying the inhibition of interferon signaling by viruses STAT2 TYK2 JAK1 PMC4504428__F2 MDM2-p53 Pathway in Hepatocellular Carcinoma ING1 MDM2 KLF6 SIRT3 PMC2905205__F1 Signalling routes of copper and hydrogen peroxide ABI2 HEL-S-162eP PMC9558762__F3 Physiological and pathological roles of Hic-5 in several organs (Review) TLR4 SMAD2 SMAD4 ARHA FADD TCF4 PMC8291223__F8 A High-Grain Diet With a Buffering Agent on Milk Protein Synthesis in Lactating Goats EEF2K LAT2 EEF2 CSN2 EIF4E MTOR EIF4B RHEB PMC9389465__F2 Glucose transporters: Important regulators of endometrial cancer therapy sensitivity EGF ABHD5 MTOR HTRA3 PMC4050178__F1 Brief Overview of DNA Damage Repair: Three common types of DNA damage are depicted in this image as well as an summary of the pathways/proteins that are activated in response to each type of damage ATM ATRIP SSB ATR PMC5204344__F4 let-7c and miR-10b target multiple genes in regulatory networks CTBP2 KIT NCOR1 SDC1 CRABP2 TRIM71 SMAD6 RPS6KA5 E2F5 RSF1 CHD4 CENPP MBD3 ALDH1A3 ASXL1 RBP4 PKD1 GMNN DYRK1B MASTL TRIO PMC8804744__F3 Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis EGF IL1B BAX PMC11863469__F10 PI3K/AKT/mTOR pathway in GBM progression TSC2 BAD TSC1 PTEN EIF4E DEPTOR RHEB MLST8 PMC7656585__F2 CP-25 on cells and possible mechanisms TH CXCR5 CD83 CXCL13 CD27 CXCR4 CD40 CD80 CXCL12 ACD ARG1 TRAF2 ADRBK1 IL1B CD19 PMC11863469__F11 TGFB signaling in GBM progression SMAD2 IL2 TGFBI PMC4397972__F4 Gene network analysis for 18 key genes involved in age-dependent tumor progression HEXA SDC1 EXT2 EIF3A HEL-S-99n CASP3 HEL-S-94n HEL-S-269 POLR2A CCNB1 S100A4 TGFB1 B4GALT1 FADD ARHGDIB BAX PMC11863469__F12 Notch signaling in GBM progression HEY2 PTEN HES1 PMC6894939__F2 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? FBP2 PC PCK1 FBP1 CIT PCK2 MAL PMC8290014__F6 TLR4 in parthanatos and the MyD88 and/or the PI3K signaling pathway in parthanatos TLR4 EGFR MYD88 PMC9366916__F3 Breaking the aging epigenetic barrier ATM RAD50 ATR PMC6894939__F5 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? PC PCK1 FBP1 PCK2 PMC6148080__F19 SST5signaling leading to inhibition of hormone secretion and proliferation SST HEL-S-11 GC GAL MTOR PMC9177323__F6 Single-Cell Analysis Reveals the Role of the Neuropeptide Receptor FPR2 in Monocytes in Kawasaki Disease: A Bioinformatic Study TH CACYBP TPM3 HEL-S-99n TFRC LCP1 ACTR2 HEL-S-68p PMC11764157__F6 CBG on AD models IL33 TYK2 JAK1 TSLP IL1B PMC3469658__F5 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes TUBA1A MYC APP HEL113 LCP1 IL1B PMC8705098__F2 Complement System in Alzheimer’s Disease HEL-S-62p C4B_2 PMC3469658__F6 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes HSH2D CASP3 HEL57 NAIP PPP5C RETNLB HEL-S-52 UNK CTNNA1 HSPD1 TNF ARHGDIB PMC3469658__F3 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes FACL4 MYC CD244 LXN CNN3 DKFZp686L0365 NDUFS1 IL2 RPS12 PHF5A RPL37 SNX6 TNF HRAS PHGDH RPL39 RPL8 PDZD2 IL15 RPL7L1 TPP2 HNF4A CUTC HEL-S-66 HEL-S-93 PMC3469658__F4 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes AKAP12 EGFR SNX6 TNF PHGDH SELL IL15 PLEKHA2 HNF4A TREML2 SNX2 HEL-S-66 GNG11 TIA1 NOS2 BRD2 CRBN PMC4100211__F1 Proposed frame work for mRNA nanoparticle mediated tumour vaccination TLR7 CD27 TNLG8A CD40 IRF3 CD80 MYD88 TLR3 PMC6370632__F1 Signal transduction pathway related to the immune-regulation of botanical polysaccharides in macrophage activation CD14 FOS TRAF6 MYD88 JUN PMC3144530__F1 Schematic overview of proposed G protein-coupled oestrogen receptor 1 (GPER1) signalling EGFR SRC HBEGF GPER PMC6620384__F1 Regulatory mechanisms of Robo4 and their effects on angiogenesis VEGFA SRC ROBO4 ROBO1 SLIT2 ARF6 PMC4280516__F2 Cellular entry of HCV particles CLDN1 EGFR LDLR HRAS CD81 PMC3969788__F4 Strategies for Delivery of Therapeutics into the Central Nervous System for Treatment of Lysosomal Storage Disorders EEA1 SRC RHO PMC3959213__F10 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway PRMT1 F2 PMC7957493__F4 Mutations in components of niche-signalling pathways lead to “ISC emancipation” and subversion of homeostatic mechanisms EGF HGF GSK3B MYC SNAI2 SMAD4 PTEN RHO GPR49 FBXW7 HES1 BMP4 GREM1 IL17RA IL17A NOTCH1 ASCL2 SFRP1 AXIN2 SFRP4 RNF43 BMP2 APC CD44 SFRP5 PMC11863469__F17 SHH signaling pathway in GBM, particularly in GSCs: In the absence of the hedgehog (HH) ligand, the Ptch receptor inhibits Smo, leading to the formation of GliR, a repressor that suppresses the expression of target genes SUFU SHH SMO PMC6024750__F3 Outline of the three main pathways of colon carcinogenesis BRAF APC MSH6 MSH2 PMS1 PMC3631444__F6 The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells DHRS9 CYP11A1 HSD17B3 CYP17A1 STAR PMC6594622__F5 Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures TXK CCL8 IL1A TEC TNF ITK BTK TNLG8A TRAF1 TNFSF10 BIRC3 CXCL9 BMX TNFAIP3 CLIC4 CXCL11 PMC11863469__F16 Complex and dynamic interactions between signaling pathways in shaping GBM progression, therapeutic resistance, and disease outcomes (*To draw this figure, data from the reports in references [39, 146, 155, 245, 249, 294, 333–380] were used DDR1 BRAF IGF1 EGFR CD44 ARHA RAC1 CDC42 PMC6148080__F20 Differential trafficking of somatostatin receptors SST PPIG HEL-S-69p PMC8649443__F6 Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension ALDH18A1 ARG1 GLS PMC4357780__F3 iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies MAFK COMP IFNG PMC6176117__F3 Schematic outline of the intracellular signalization in the retinohypothalamic tract BDNF SIRT1 PER1 PMC5610669__F3 Examples of IGF-targeted agents IGF1R IGF1 IGF2 PMC5610669__F4 Crosstalk between IGF-1R and other RTKs/steroid hormone receptors IGF1R ALK EGFR MTOR IRS1 INSR PMC5564764__F7 BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways BMX MTOR STAT3 PMC8972406__F1 Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System PTS NHS THRA PMC4103166__F3 Circadian Clock in Cancer Development and Therapy ATM PMC3691869__F6 Schematic outline of the regulation of EGFR internalization and mediated signaling by the CIN85–SH3GL2–Cbl complex EGF SH3GL2 EGFR STAT3 PMC6601370__F10 KEGG pathways enriched by the differentially expressed mRNAs in the competing endogenous RNA network DAO RHO CAD LAT PMC10536053__F3 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer POLE BLM RAD52 ERCC1 DNA2 PAXX PMC10536053__F4 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer TBK1 CGAS CXCL10 SSB IRF3 CCL5 IL15 WEE1 ATM CDK2 RAD50 CDC2 ATR PMC4401125__F1A HSPs regulatory function in the intrinsic (A), extrinsic and caspase independent pathways to death (B) BAD CAD BAX GATA1 PMC8666431__F7 Precise Identification of Recurrent Somatic Mutations in Oral Cancer Through Whole-Exome Sequencing Using Multiple Mutation Calling Pipelines ITPR2 PLCB3 ALK EGFR FGFR3 FGFR2 PLCB1 PRKCA FGFR1 EP300 PIK3CA ROS1 IGF2R PMC4201519__F2 Integrated microRNA and mRNA Transcriptome Sequencing Reveals the Potential Roles of miRNAs in Stage I Endometrioid Endometrial Carcinoma E2F4 GSK3B SMAD4 DBF4 CDK7 CDK6 CSTA CDC20 CDC6 CDK2 MDM2 ORC1L CDK4 CDC2 RAD21 PCNA SKP2 MYT1 PMC3287586__F2 Preimplantation development pathway AFP FGF4 SNAI1 PSG2 LEFTY1 LEFTY2 MYC TEAD4 HAND1 DSC2 SOX17 BMP4 GCM1 DPP3 COX2 SAP18 FOXD3 FGF3 ESRRB PARD3 RPS14 TCF3 SOX2 LIF CER1 LAMB3 KRT18 GATA4 THY1 GATA2 GIG8 CDX2 GJB3 KLF4 SMAD1 TLE2 STAT3 PMC10857159__F6 Expression of DEGs involved in the plant hormone signal transduction pathway of M BIN2 TF PMC10744863__F1 Pathophysiology of acquired aplastic anemia (AA) IFNG STAT3 FOXP3 PMC10031108__F9 Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway KEAP1 APAF1 BAX PMC5610669__F1 Components of the insulin/IGF axis IGF1R IGF1 IGF2 IGF2R PMC5610669__F2 IGF-1R downstream signaling TSC2 BAD TSC1 IGF1R IGF1 GRB2 PTEN IRS1 INSR PMC8258330__F2 Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020 PLCB2 SEMA7A SEMA3A PKD2L1 OTOP1 CALHM3 CALHM1 TRPM5 PANX1 PMC4934657__F3 Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy PALB2 UBE2T ATR USP1 PMC8687625__F9 Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis CD14 BAD MIP RAC1 TNF tal-1 MID1 TLR4 BCR ATM FRK VCAM1 ADA SYK PMC8824883__F2 Cell division control protein 42 in tumor and non-tumor diseases: A systematic review EGFR CDC42 PMC9359465__F2 Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment VCAM1 RHO RAC1 TNF PMC5749629__F2 Hepatic methionine metabolism is closely linked to GSH synthesis HEL-S-61p PMC8625415__F8 Prognostic Biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) Family Members in Breast Cancer CENPB CDC20 KNTC2 APC INCENP SELL NSL1 PMC6150985__F2 P53 is the most important regulator in DNA damage ATM ATR BAX PMC6514907__F1 Enhancement of SUMOylation in glioblastoma contributes to alterations in multiple cellular processes leading to an increased malignant phenotype SENP1 PIAS1 SAE1 CDK6 SUMO1 PMC4732808__F9 Blockade of KCNN4 by Clt accelerates wound healing at least in part by transactivation of the PI3K pathway EGF EGFR KCNN4 CIT PMC4059167__F1 Canonical catecholaminergic neuron is one that generates dopamine, noradrenaline or adrenaline TH PNMT DBH PMC4144112__F1 Genistein modulates a critical TGFB signaling pathway in human prostate cancer MAPKAPK2 ENG SMAD1 PMC4876503__F6 Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a STAT1 IFNA1 IFNAR1 MAVS PMC9459389__F3 Mechanisms of ferroptosis and its role in alzheimer’s disease GPX4 LPCAT3 SLC7A11 GSK3B FURIN GLS PMC8191844__F1 Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity PTEN ARG1 PMC6357148__F2 Filovirus replication cycle showing host and viral proteins that either promote (green boxes) or block (red boxes) virion assembly and release TSG101 ISG15 SOCS3 BAG3 WWP1 NEDD4 ITCH PMC7519203__F2 Proposed mechanisms and time course of SARS-CoV-2 infection when using a ketone-based metabolic therapy TH FOXO3A IRF3 PDK4 HIF1A ACE2 FOXO1 PMC4372177__F5 Top Kegg pathways enriched with aDMCs identified by the FatiGO analysis INS FOXA3 HNF1A CAD TNLG7C IFNG HES1 PMC5916961__F1 Mitochondria are a platform for pattern recognition receptors (PRRs) signal transduction and regulation NLRP3 TLR7 TANK TLR4 IRF7 TRAF6 IRF3 ECSIT TLR1 IL1B MAVS PMC7519203__F8 Proinflammatory signaling that occurs during viral infection and mechanisms through which R-BHB inhibits this signaling PTMS IRAK1 TRAF6 IRF3 MYD88 NOD2 NLRP3 TLR8 TLR7 OGT TXNIP FADD MAVS STAT3 PMC4261510__F1 Wnt/Beta-catenin signaling pathway APC GSK3B TEF LRP5 CCND1 LRP6 PMC3650620__F4 Cross-talk between insulin and inflammatory signaling pathways NLRP3 TLR4 TRADD TNF MTOR TRAF2 IRS1 STAT3 PMC4261510__F2 Hippo signaling pathway NF2 PMC8504269__F2 Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells RUNX2 ARHA PMC10938139__F2 Research progress of periostin and osteoporosis LEF1 APC PMC10938139__F1 Research progress of periostin and osteoporosis BMP1 CAV3 MSC LRP5 LRP6 PMC7349630__F2 Signaling pathways and mechanistic drivers of epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndMT) in age-related macular degeneration (AMD) VWF MTOR PMC10669822__F6 “PPAR signaling pathway” was an upregulated KEGG pathway for the transcriptomics profiling of HMEC-1 treated with MPE (0 UBC OLR1 PLTP UCP1 AQP7 HEL-S-28 LPL CYP1A1 PMC8678153__F4 Synthetic lethality of ATM and ATR WEE1 ATM ATR PMC3660856__F3 Molecular Basis of DNA Recognition in the Immune System NLRP3 AIM2 IL1B PMC6873089__F2 Mutational landscape of HCC KEAP1 APC ALB NFE2L2 VEGFA ARID2 PTEN RB1 MTOR CDKN2A CCNE1 TSC2 PI3 APOB TSC1 HEL-S-78p ATM AXIN1 FGF19 IL6ST JAK1 TERT PMC9599207__F1 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside YAP1 LATS1 LATS2 PMC12130507__F5 KEGG pathways “VEGF signaling pathway”, significantly associated with CD36 abundance COX2 BAD CDC42 PMC9599207__F2 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside YAP1 LATS2 PMC12130507__F6 KEGG pathways “Glutamatergic Synapse”, significantly associated with CD36 abundance DAO GLA PMC8509025__F1 Molecular Functions and Pathways of Plastidial Starch Phosphorylase (PHO1) in Starch Metabolism: Current and Future Perspectives MOS FRK GPT SHE PMC5136711__F1 Diagrammatic representation of the extrinsic and intrinsic apoptotic pathways CASP3 CASP9 DIABLO FADD BAX PMC12130507__F4 KEGG pathway “Regulation of lipolysis”, significantly associated with CD36 abundance PDE3B NPY TSHR CIDEC ACP7 INS COMP INSR PMC10672452__F1 LPS-induced inflammatory response of the innate immune system and the anti-inflammatory effect of LPS-binding peptides/proteins from marine invertebrates CD14 LBP MYD88 PMC9122124__F2 Macrophage: A Cell With Many Faces and Functions in Tuberculosis STAT1 CXCL1 BAD TLR4 CXCL10 ARG2 KLF4 CXCL9 STAT3 HEL-S-5 PMC5225790__F13 VEGF/VEGFR signalling pathway in normal vs SEMA3A NF2 NRP2 PMC8836075__F2 Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? AHR SRC NQO1 PMC7914659__F1 Three major sources of H2S: enzymatic pathway, nonenzymatic pathway, and bacterial origins DAO PMC5626595__F1 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES ISG15 CGAS USP15 IRF9 ATF2 IRF3 IFNAR2 JAK1 IFNAR1 TRIM25 MAVS MX1 PMC5626595__F2 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES CGAS STAT2 IRF7 IRF9 IRF3 IFNAR2 IFNAR1 MX1 TRIM23 STAT1 ISG15 UBR4 MAVS PMC5056327__F1 Phosphatidylinositol 3 kinase/Akt pathway TSC2 BAD TSC1 MDM2 PFKFB2 PTEN IRS1 CD19 PMC5225790__F11 Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies BRAF NRAS MDM2 SPRED1 SHOC2 PTEN SOS1 HRAS PPIC PMC3047086__F9 Suggested modes of the involvement of Nrf2/ARE in the regulation of AML cell differentiation MAF NR1i1 KEAP1 FOS ATF2 JUN PMC10604902__F1 Oxidative stress from dysregulated NOX activation and mitochondrial dysfunction regulates the signaling pathways involved in initiating and maintaining AF CXCL1 CD44 NOX4 IL8RB RYR2 STAT3 PMC6202553__F4 Gene networks KIT PDGFRA IGF2 VCAN ERBB3 PSCA IGFBP5 PLAT FGFR1 MMP2 PTCH1 BCL2 CXCL12 GAL NTRK2 PMC9584359__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis SLC25A32 PSAT1 SFXN1 PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC11880705__F3 NS1 in counteracting innate immunity1: Binding of NS1 to p85Beta-SH2 relieved p85B repression of p110a, activated PI3/Akt signaling, and inhibited the apoptotic program induced by influenza virus RNASEL OAS1 IRF3 TRIM25 PMC4702030__F4 A - Ingenuity pathway analysis of genes involved in human epithelial ovarian cancer (EOCs) and other associated diseases that have overlapping pathways CHEK2 NF1 EP300 ATM TGFBR2 PTEN RB1 CDKN2A PMC11885102__F4 Schematic diagram of the regulation of intestinal ACE2 on islet function GPR142 ACE2 PMC5642919__F5 Proposed model SMAD2 IL36A SMAD4 PMC7758911__F1 RTKs and ERA36 in the development of tamoxifen resistance EGFR CCL2 MTOR PMC9424771__F8 Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking FOS TRAF3 TNF NOD2 CEBPB MMP3 CASP3 MMP14 HEL-S-11 TRAF1 JUNB TRAF2 JUN MME FADD SELE ITCH PMC6462522__F9 BIN1 loss enables ATM activation by the nuclear protein E2F1 ATM BIN1 MDC1 PMC6116613__F3 MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE FGF21 ATF4 OPA1 PMC11859690__F2 Action of anti-HER2 drugs APC PTEN MTOR PMC11860879__F1 Signaling pathways in the immune TME in AOC CXCL2 CD80 TNF TRAF2 STAT3 PMC11860879__F2 Multiple signaling pathways in the non-immune TME in AOC ATP7B ATM ATP7A EGFR GSK3B GRB2 SHE MTOR ATR MEF2D PMC4136812__F4 Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11Beta-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in Colon Cancer Cell Lines IGF1 HSD11B2 AEBP1 GRB2 MTOR IRS1 HDAC1 HEL-S-133P PMC7903415__F1 The signaling pathways in LF by lncRNAs PMC11860879__F4 Applications of NPs to reverse the non-immune TME in AOC NPS BRCA1 MEF2D PMC3733544__F7 FA/BRCA DNA damage response pathway PALB2 BRCA2 BRIP1 UBE2T BRCA1 USP1 PMC9321592__F6 IL‐20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis CXCL1 MAX NPY CCL2 VIP ITCH PMC9197867__F2 Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases PI3 COX1 VEGFA VEGFB PMC408106__F1 Partial synthesis pathway of GSLs HEL-S-111 PMC11880705__F5 Applications of live attenuated influenza a virus with modified NS1 gene TLR7 IRF7 IRF3 TLR3 PMC4541706__F1 The unfolded protein response ATF4 EIF2A XBP1 PMC8507154__F2 Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches RET FYN GDNF SRC PMC4671996__F4 Transcription factors and genes that regulate PDKs regulation PDC MYC MTOR HEL-S-133P PMC4853752__F1 MicroRNA network that is involved in regulating myogenesis SMAD2 PAX7 SMAD4 DEK MTOR FGFR1 MYF5 RYBP CCND1 YY1 EZH2 SP1 SMAD1 PMC4671996__F2 Illustration of Warburg effect in cancer cells PDC FH HEL-S-133P PMC7775721__F2 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease GLB1 HEXA SMPD1 HEL-S-111 PMC9099719__F2 Tumour Stem Cells in Breast Cancer CIC IL6 CCL2 CXCL12 HIF1A DKFZp686F0183 SELL PMC12112599__F7 Images of the protein processing in the endoplasmic reticulum pathways enriched among the imported differentially expressed genes (DEGs) identified from the lipopolysaccharide (LPS) vs ELF2 CASP12 ATF4 SVIP SKP1 WFS1 UFD1L PAG1 SEC63 SELL BAX SEC62 PMC7775721__F1 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease NPC1 GLB1 HEXA SMPD1 HEL-S-111 NPC2 PMC9099719__F1 Tumour Stem Cells in Breast Cancer MTOR PMC6059371__F1 Function of Hsp70 in suppressing apoptosis after ischemic stroke CASP3 CASP9 CASP8 FADD BAX PMC4987408__F3 Regulation of rhein on the crosstalk of MAPK signaling pathway NLK KDR TG PMC10895590__F6 Immunorecognition of RNA/DNA fiber NANPs via the cGAS-STING signaling pathway can be regulated through functionalization with aptamers TBK1 CGAS IRF3 PMC4839494__F2 Adenosine receptor-mediated signaling pathways ADORA2A ADORA2B IL6 PMC6412520__F1 Simplified diagram of methionine metabolism (adapted from ) HEL-S-61p PMC5924476__F1 Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome TH PNMT DBH CYB561 PMC1602337__F9 TWEAK-Fn14 signaling system may play a role in stroke pathophysiology TRAF5 TRAF1 TRAF3 TRAF2 PMC6315862__F2 Overview of the DSB repair mechanisms RAD52 PMC12199384__F1 Core‐shell manganese phosphate nanomodulator enhances anti‐tumor immunotherapy via bidirectional reprogramming of the tumor microenvironment HMGB1 ADA CD44 PMC4749490__F1 Hypothesis: central neuroendocrine and peripheral mechanisms in generation of sex bias in PH PAH BCL6 PMC8944072__F3 Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease SET EGFR TRO PARVA CDC42 MX1 PMC7352357__F1 Cholesterol metabolism and key oncogenic pathways related to cancer development SQLE NLRP3 PCSK9 INSIG1 ACAT1 LDLR SMO PTEN HMGCR STAT3 PMC9001073__F6 Isoflurane Attenuates Cerebral Ischaemia–Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice NLRP3 TLR4 MYD88 IL1B PMC6199630__F6 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis ATM MDC1 MDM2 RAD50 MRE11A BRCA1 BAX PMC3973632__F5 Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues CDC20 CDC6 CDK2 MDM2 SMAD4 DBF4 ORC3 CDK7 CDC45 PCNA SKP2 MYT1 PMC11670821__F1 Generation and release of exosomes in response to bacterial infection TSG101 AGO2 CD9 CD63 PMC11670821__F3 Immune responses mediated by (H) pylori OMVs and infected cell exosomes TLR4 CD63 CD40 MYD88 CD81 PMC11670821__F5 Roles of H. pylori OMVs and infected cell exosomes in the extra-gastric diseases CDX2 VCAM1 NLRP12 KLF2 STAT3 PMC6016889__F1 CLL main pathogenic pathways and target agents against BTK, PI3K and Bcl-2 ARHA PLCG2 MTOR ROR1 BTK BCR CXCR4 LYN NOTCH1 CD40 SYK ROR2 CXCL12 CD19 PMC5366100__F2 Regulation of NOX by H DUOX2 RAC1 NAPA DUOXA2 NDP NOXA1 PMC8579447__F8 PiRNA-63049 inhibits bone formation through Wnt/Beta-catenin signaling pathway AIP APC GSK3B LRP5 LRP6 WNT2B PMC6571165__F1 Signaling pathways that modulate cardioprotection in CMs CYR61 CITED4 ARHA PTEN BAX PMC6571165__F2 Signaling pathways that contribute to CF activation and stress response EGFR ARHA HDAC1 ADRBK1 BRD4 PMC3345255__F1 MAPK/ERK signaling and the hallmarks of cancers EGF BAD TNF MTOR BAX PMC12084948__F2 Signaling networks downstream of SLAMF receptors in regulating immune cells VAV1 SRC SYK SLAMF7 DOK1 PMC3926884__F1 Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab AREG EGFR GRB2 SHE IL4 MTOR PMC2958210__F12 Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice CCK PC CA3 IPP PMC12084948__F4 SLAMF receptors modulate cancer progression SLAMF8 SLAMF7 CCL2 PMC10506410__F3 Vitamin D receptor deficiency may induce alopecia through the Ddit4/mTOR signaling pathway TSC2 BMP1 NR1i1 DDIT4 PMC9468787__F1 Nexus of lipid and O-Glcnac metabolism in physiology and disease OGA OGT XBP1 PMC10506410__F1 MTOR Signaling Network (A) Overview of the mTOR signaling pathway (B–D) mTORC1 signaling in mRNA translation, metabolism, and protein turnover (E) mTORC2 signaling function ULK1 SLC38A9 EGFR GSK3B TBC1D7 PTEN EIF4E HIF1A FOXO1 MTHFD2 RHEB TSC2 NF1 TSC1 TFEB ATF4 GRB2 UVRAG CAD EIF4B PMC8405566__F3 Candidate model for Ccr4-Not mediated nutrient signaling RRN3 CCR4 ARF1 POLI PMC7075943__F1 Predicted lipid synthesis pathways of phospholipids in E PI3 PC PGP PMC8178461__F1 Roles of PD-1/PD-L1 in the prognosis and immunotherapy of prostate cancer LIF LRP11 PTEN STAT3 PMC7291472__F1 Diagram of CD155/CD112-mediated immunoregulatory pathway on NK cells CD96 TIGIT CD226 PMC8511527__F1 Endoplasmic Reticulum Quality Control in Immune Cells ATF4 EIF2A TRAF2 XBP1 PMC4032983__F6 CK1 in Wnt-signaling APC LRP5 LRP6 ARHA RHO SIPA1L1 PMC4032983__F8 CK1 in Hippo signaling in vertebrates NF2 LATS1 LATS2 PMC9315518__F10 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma ORC6 SMAD2 SMAD4 MCM7 STAG1 DBF4 CDK7 STAG2 CDC45 ORC2 MCM3 CDC20 CDX2 HP CDC6 SMC3 CDK2 MDM2 CYC1 PCNA SKP2 MYT1 PMC6134416__F1 小细胞肺癌的的分子发病机制 CDK2 CDK4 BAX PMC12006098__F10 Galangin attenuated MPTP-induced brain tissue injury in PD model mice, and the related mechanism may be related to the PI3K/AKT signaling pathway TH MTOR BDNF PMC4107035__F2 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA NF1 TSC1 GRB2 EIF4E MTOR STRADA RHEB STAMBP PMC6134416__F3 在SCLC中，受体酪氨酸激酶及其配体通常呈过表达状态。缺陷性受体酪氨酸激酶及它们各自的生长因子包括：VEGFR/VEGF, c-Kit/SCF, c-MET/HGF, FGFR/FGF以及IGF-1R/IGF。通过多种通路的激活，包括在SCLC中失调的PI3K/AKT/mTOR通路，在存活、凋亡、细胞周期调节和翻译过程中发挥作用。Receptor tyrosine kinases and their known ligands are often overexpressed in SCLC IGF1R HGF PTEN MTOR PMC8965611__F5 Signaling Pathways Associated With Breast Cancer Bone Metastasis MYC SRC TRAF6 LRP6 FGF18 MTOR JUN FGF20 PMC4107035__F3 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA NF1 TSC1 GRB2 PTEN MTOR STRADA RHEB STAMBP PMC2151841__F4 Signal transduction pathway in the UPR ELF2 ATF4 TRAF2 PMC5971224__F1 Fatty acid (FA) and ceramide synthetic pathway in autosomal recessive congenital ichthyosis converge on the corneocyte lipid envelope (CLE) ALOXE3 DGAT2 ELOVL4 PEX2 ALDH3A2 CERS3 TG ALOX12B LIPN PMC4319960__F7 SMAD-Independent Down-Regulation of Caveolin-1 by TGFB: Effects on Proliferation and Survival of Myofibroblasts SMAD2 PMC83966__F7 Ras effector pathways in NGF stimulated PC12 cells PI3 NGF CDC42 PMC7464644__F3 Role of Tumor-Associated Myeloid Cells in Breast Cancer MMP9 ARG1 STAT3 PMC7464644__F2 Role of Tumor-Associated Myeloid Cells in Breast Cancer EGF CXCL1 SEMA4D EGFR CCL18 CSF1 ARG1 ADM EPHA4 STAT3 PMC8489191__F1 Post-translational modification control of viral DNA sensors and innate immune signaling TBK1 CGAS TLR9 DDX41 DHX36 IRF3 MYD88 MRE11A HNRNPA2B1 HEL-S-72p AIM2 MAVS IFI16 PMC12145212__F9 Mechanisms by which hypoxia impairs spermatogonial proliferation CCND1 CDK4 CDK6 PMC12029571__F4 UPR pathway ATF4 TRAF2 XBP1 PMC7155770__F4 Death receptor pathway of apoptosis RIPK1 TRADD SHARPIN RELB RIPK3 TRAF2 FADD MLKL PMC12029571__F1 Main metabolic pathways involved in cancer MYC CPT2 GLS PMC12029571__F2 Main metabolic pathways involved in cancer SCD CPT2 TG FASN HEL-S-5 PMC7155770__F3 Mitochondrial pathway of apoptosis APAF1 DIABLO HTRA2 PMC7906172__F9 ADSCs promote functional recovery after spinal cord injury by activating the TGFB1/Smad3/PLOD2 signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 PLOD2 PMC5617400__F4 Autophagy-related gene expression is an independent prognostic indicator of glioma RREB1 MAPK9 E2F4 TCF3 ATG12 ATG3 MAPK8 MAP3K11 SH3GLB1 CTCF SH3RF1 ATG10 MTOR DKFZp686F0183 GATA2 FOXP3 FOXP2 UVRAG ATG14 PPARG IRF-1 IRF2 PMC9656839__F8 High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role TSC2 TSC1 IGF1R MTOR IRS1 RHEB PGAM2 PMC3132733__F1 Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures TRAF3 FADD PMC6477898__F4 Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease CPT1A ABCG1 WAS PMC9290759__F2 Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases COX2 AHR PMC9701576__F3 Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics FOXA1 ERG DBP APC MNX1 PTEN RGS12 UBB TMPRSS2 FASN PMC9528914__F1 Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment PC BRAF APC PMC7541127__F4 Landscape of major pathway alterations in primary GBM BRAF PDGFRA CDKN2C DKFZp781B1423 EGFR PTEN RB1 CDKN2A CDK6 NF1 CDKN2B MDM2 CDK4 PMC10705747__F6 CBD’s neuroprotective mechanism in ABeta-induced impairments HEL-S-2a SLAMF8 CTSC GDNF PLCG2 BDNF GRN PMC9495798__F9 Physiological and Comparative Transcriptome Analysis Reveals the Mechanism by Which Exogenous 24-Epibrassinolide Application Enhances Drought Resistance in Potato (Solanum tuberosum L.) TH BIN2 WAS PMC11281541__F10 Hypothetical schema of the protective role of MIN in TBEV-infected Vero cells EGFR SYT11 SNAP25 RYR2 PMC3821994__F1 PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops TSC2 EEF2K RICTOR TSC1 EEF2 MTOR BDNF RHEB PMC3004523__F2 Hypothetical roles for LAB-dependent positive signaling KIT FYN IL3 GAB2 LYN GRB2 SYK PMC4841221__F1 Changes to coral health and metabolic activity under oxygen deprivation HEL-S-62p AIP C6 PMC6481742__F1 Schematic representation of the major components of the endosomal pathway and the generation of exosomes TSG101 CD9 CD63 EGFR EDIL3 HMFT1766 CD81 CD24 PMC3975402__F2 Apoptosis pathway BAD APAF1 FADD BAX PMC5264260__F2 Intracellular signaling pathways of A7nAchR in anti-inflammatory response HMGB1 TLR4 IRAK4 MYD88 IL1B STAT3 PMC9472579__F1 Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus TBK1 STAT1 ISG15 OAS1 CGAS TLR7 STAT2 IRF3 TRIM25 TLR3 PMC4576457__F7 Hypothalamic PKA regulates leptin sensitivity and adiposity POMC SOCS3 STAT3 PMC8509318__F2 Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NFKB Activation: A Review of the Molecular Mechanisms DUSP2 SIAH2 PMC9530862__F2 Effect of fasting on cancer: A narrative review of scientific evidence IGF1 LAMP2 MTOR SIRT1 PMC12024365__F8 Diagram of PPAR signaling pathway SCD PCK1 APOC3 HEL-S-104 PMC9709415__F3 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway TLR4 KEAP1 GSK3B MYD88 IL1B NQO1 PMC2994272__F8 Carnosol in human prostate cancer PC3 cell line TSC2 TSC1 PTEN MTOR PMC5862044__F1 Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence TH MYC HIF1A MTOR PMC9709415__F1 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway MAF KEAP1 PMC7363928__F8 Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling CXCL1 TLR4 IL8RB HEL-S-133P PMC4631823__F1 Model for brassinosteroid (BR) signaling pathway in the absence and in the presence of BR IWS1 BAK1 BIN2 PMC4842059__F3 Id2 network model in insulin signaling, thermogenesis, and adipogenesis pathways LIPE PRDM16 GIG8 UCP1 TWIST1 NR1C1 BMP4 RXRA FASN PMC10912430__F6 Signaling pathways that may be triggered by cellular autophagy during intestinal I/R ULK1 NLRX1 FUNDC1 TXNIP PMC10912430__F4 Signaling pathways that may be triggered by cellular pyroptosis during intestinal I/R NLRP3 RIPK1 TLR4 EGFR RIPK3 TXNIP PMC5337147__F2A Post-transcriptional regulation of cytokine and growth factor signaling in cancer HEL-S-62p EGF BAD TWIST2 HGF GSKIP SKIL TGFBR1 EGFR TGFBR2 VEGFA ARHA MTOR SMURF1 HMGA2 ELAVL1 CELF1 GIG8 FRS2 GRB2 CDH2 TGFB1 STAT3 PMC8478533__F3 Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway EREG BAD TLR9 ACACA CRY2 ALOX12 CCL21 SELL AQP3 MTF1 SYMPK SCD SSPN ELANE CAD ACTN4 BPI STAR PER1 CD14 ETV3 UXT USF2 PURA AURKA FUS DBI HEL164 NR2C2 ZNF143 TXNIP HEL113 ATP2A2 TRIM28 GNAS MAVS CDC42 CPD PMC9437486__F6 Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway GPX4 KEAP1 SLC7A11 PMC10912430__F5 Signaling pathways that may be triggered by cellular ferroptosis during intestinal I/R GPX4 FACL4 SLC7A11 TRPV1 TERT PMC8880424__F6 Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress C9 PGP PSD PMC8183045__F8 Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis MEN1 GIP IPP PMC10912430__F3 Signaling pathways that may be triggered by cellular apoptosis and necrosis during intestinal I/R PINK1 PIN1 MAPK13 HDAC3 TRAF3 PKD1 PRDX3 BAX SIRT3 PMC9434120__F1 Relationship between metabolic reprogramming and drug resistance in breast cancer F2 BCAT2 MYC PSPH TG LAT FASN HEL-S-162eP GLS PMC9434120__F2 Relationship between metabolic reprogramming and drug resistance in breast cancer MTOR ITGB1 PMC7516048__F2 Model for B. pertussis CyaA regulated complex signaling pathways to block the monocyte differentiation and to trigger macrophage dedifferentiation ARHA LATS1 LATS2 PMC10912430__F1 Signaling pathways that may be triggered by cellular oxidation or inflammation during intestinal I/R SIRT6 TRAF3 PRDX3 NR1C1 NQO1 BAX SIRT3 PMC3078450__F5 Network annotation of genes differentially expressed according to the CD133 status in HT-29 using ingenuity pathway analyses TNC FGFR1 WNT3A IL13 APC PAXIP1 FGFR3 BMI1 CDKN2A PMC9688046__F2 USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective MDM2 FOXP3 PMC8065217__F1 Spatiotemporal regulation of hydrogen sulfide signaling in the kidney DAO PMC6443339__F12 Regulatory effects of H2S on PCSK9 expression and lipid metabolism PCSK9 LDLR ABCA1 PMC9317282__F12 Comparative Transcriptome and Interaction Protein Analysis Reveals the Mechanism of IbMPK3-Overexpressing Transgenic Sweet Potato Response to Low-Temperature Stress MYB MYC ERF TF PMC4125416__F2 Adaptive immunity with Toll-like receptors IRF7 TRAF6 EIF4E MYD88 MTOR PMC9146250__F3 New Insights into Hematopoietic Stem Cell Expansion to Stimulate Repopulation of the Adult Blood System for Transplantation AHR BRPF1 CD34 LYN SRC MTOR THPO PMC6450748__F10 Ethanol induces hyperacetylation and hyposuccinylation of mitochondrial proteins involved in diverse metabolic pathways ACOT13 GPX1 CPT2 ATP5F1D HEL-S-5 MDH2 ACAT1 GOT2 PC NDUFS1 FH MPC2 DHRS4 PRDX5 ACSF2 ETFA SDHA ETFB OTC DLD UQCRC2 NDUFA2 NDUFB3 HEL-S-123m SUCLA2 HEL-S-271 ATP5F1E GLUD1 ALDH2 PMC8925223__F1 DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis DHCR7 SC5D DHCR24 HMGCR PMC10030580__F2 Macrophages in aseptic loosening: Characteristics, functions, and mechanisms NLRP3 LTA TRAF6 MYD88 MTOR IL1B TAB3 PMC4835794__F2 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns PRKAA2 PTEN ULK2 CAB39 TNF HIF1A IRS1 DDIT4 STRADA RHEB TSC2 TSC1 IGF1 RPS6KB2 STK11 MAPK1 EIF4B AKT3 PMC4835794__F3 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns BRAF PRKAA1 CAB39 HIF1A IRS1 STRADA PDPK1 RHEB TSC2 TSC1 IGF1 MAPK1 EIF4B AKT3 PMC8799702__F5 Protein tyrosine phosphatases in skeletal development and diseases MGP RUNX2 BMP2 SMAD2 GSK3B PTH PTEN BMPR2 FRS2 GRB2 SMAD1 DKFZp781O1323 STAT3 PMC4981357__F7 Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity UBA2 SAE1 STAT3 PMC11748936__F7 SIGLEC11 promotes M2 macrophage polarization through AKT–mTOR signaling and facilitates the progression of gastric cancer MTOR TGFB1 SIGLEC11 PMC8889706__F8 LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation ABCG8 ABCG5 LDLR PMC8496081__F5 Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors TAF1 TBP TAF9 TAF6 PMC6159521__F4 Schematic drawing of the asymmetric specificity of the EndoMS-dependent MMR system and asymmetric occurrence of replication errors GC PMC11430996__F4 Effect of anthocyanin on initiating apoptosis in human colon cancer line BAD BAX PMC8606538__F1 Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets SQLE FDFT1 ABCG1 LDLR SOAT1 RHO ABCA1 HMGCR PMC6033520__F1 Hedgehog pathway in nonalcoholic fatty liver disease PC IL3 SMO PMC3137639__F5 Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases SEMA4B NDRG2 BAD LARP1 EGFR ARHGEF12 GSK3B ARHGAP19 AKT1S1 GOLGA4 SGTA TCF12 MTOR FGFR2 SP100 FRS2 UBXN4 TAF3 UBR4 RPS6 CD2AP SVIL IWS1 STX7 TCF3 MEPCE FOXO3A PDGFRA NDRG3 WNK1 GSK3A DNAJC2 TBC1D4 IRS1 OXR1 PANK2 EDC3 TSC2 RICTOR GTF3C1 PFKFB2 KIF21A HEL-S-100n EPHA2 BRD2 LMO7 STX12 EIF4ENIF1 PMC6714586__F1 Main signaling pathways implicated in VE-cadherin/VM-positive cells NRP1 CCND1 CAD PMC3976810__F2 Molecular pathways are altered due to modulation of signaling pathway in skin cancer IL10 CASP3 MPO CASP8 PCNA BAX PMC7816290__F10 Schematic summary demonstrating the molecular mechanism of anti-ALR McAb inhibiting the proliferation of U266 cells CCND1 CDC2 STAT3 PMC4516482__F7 The hypothetical mechanisms involved in fibronectin-induced P2X4R up-regulation in microglia LYN MDM2 EIF4E PMC7018659__F8 Possible mechanism underling periodontal inflammation-induced metastasis NLRP3 TLR4 CXCL5 CCL5 CCL2 CXCL12 IL1B PMC9068916__F7 SP1-mediated oncogenic mechanism in CRC progression KDM2A TUG1 SP1 PMC6706905__F7 Systemic diagram of the mechanism of S1PR1/STAT3 signaling pathway MYC CCND1 S1PR1 STAT3 PMC2700213__F1 Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians POMC ASIP TYRP1 SLC24A5 PMC8789654__F5 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway IRAK1 MYD88 HDAC1 PMC8789654__F6 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway CASP3 AREG EGFR CCND1 SRC PMC8789654__F4 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway CASP3 NLRP3 SOCS3 CYP3A4 FOXA1 ERG PTPRO SP1 MTOR CYP1A2 PMC11012077__F2 Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease—Is There a Link? CX3CR1 VCAM1 CX3CL1 RELA RELB PMC6015375__F6 Schematic demonstrating of [U‐13C]glucose to CAC and PPP, and protein expression levels in HBP PDC CS OGA OGT PMC9302585__F1 Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture CASR TRPM6 TRPV5 PTH PMC5313050__F3 Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol CYP2C9 ACOT4 CPT2 PMC11930710__F2 Model illustrates how resistance to EGFR-targeted drugs develops due to the loss of PTEN expression, caused by impaired nuclear translocation of EGR1 in lung cancer cells: A EGR1 EGFR PTEN PMC2889681__F1 Neurotrophic and neuroprotective pathways targeted by lithium MARCKS BAD GSK3B BDNF PMC7603631__F6 Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1A Signaling Pathways Mediated by the NAMPT-NAD Pathway SIRT2 NAMPT SIRT1 SIRT3 PMC8014352__F5 Potential pathway of IGFBP-1 in the present review PGR IGFBP1 SRC NR2F1 PTEN ZIC2 MTOR IRS1 PMC9234081__F6 Dietary cholesterol promotes growth and ecdysone signalling pathway by modulating cholesterol transport in swimming crabs (Portunus trituberculatus) ACOX1 PMC8834563__F2 Enhanced Loss of Retinoic Acid Network Genes in Xenopus laevis Achieves a Tighter Signal Regulation SQLE VIT EBP DHCR24 CYP24A1 HSD17B7 TM7SF2 CYP51A1 CYP27A1 NR1i1 CYP2R1 DHCR7 DBP CYP27B1 PMC9220817__F1 Blood Cell-Derived Microvesicles in Hematological Diseases and beyond CD14 CD9 HEL-S-171mP MPO CD44 TF CD19 PMC8923803__F9 Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma IL10 IFNL3 IL20RB EGFR IL24 IFNL1 TNF IL10RB IFNLR1 FOXP3 IFNL2 EP300 IL20RA RELA IL22 LEPR JAK3 IL10RA PMC9097137__F2 Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape MBP HEL-S-44 OLIG2 PMC3314677__F9 Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide CASP3 CDK2 GSK3B CCND1 TRAF2 CASP8 BAX PMC2657476__F1 ErbB Receptors in the Biology and Pathology of the Aerodigestive Tract BAD EGFR GRB2 SRC BCL2 STAT3 PMC5370034__F6 Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway CDK2 PCNA BAX PMC9476742__F4 Emerging therapeutic role of Prunella vulgaris in thyroid disease CASP3 TRADD CYLD CDC37 TRAF2 PMC5640159__F1 Overview of the role of CtIP in the cellular response to DSB damage ATM CDK2 ATR BRCA1 PMC9313013__F1 Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins LIAS FDX2 FXN GRPEL1 NFU1 BOLA3 GRPEL2 ISCA1 FDXR PMC4118498__F1 Clinical Reasoning: A 20-year-old woman with rapidly progressive weakness AIP HMBS PMC6245662__F6 Monoamine Oxidase Isoenzymes: Genes, Functions and Targets for Behavior and Cancer Therapy TWIST1 NRP1 VEGFA MAOA PMC3136693__F1 Chemical heme biosynthesis pathway BOC UROD UROS CPO PMC7263378__F4 Synchronized redox regulation of cysteine residues throughout canonical EGF signaling pathways at 15 and 30 minutes EGF BAD EGFR APC PAIP1 HEL-S-15 RHO MTOR CDCA2 TIMP1 MMP2 GRB2 SRC CD55 CAD RPS6 ARF6 ELF4 PMC5908849__F5 Metabolic and regulatory network of G TH FRK ACD HEL107 RPE LAT PMC7553623__F2 K-RAS pathway in cancer development EGF EGFR PMC4060285__F6 Schematic showing the protein acetylation sites in metabolic pathways that are most differentially acetylated in LDKO/flox liver CS FACL4 HADHB GCK ACSS2 HEL-S-32 MDH2 HEL-S-26 ACADS FH PKLR ACO2 OGDH PGAM1 HEL-S-133P HK2 PGAM2 SDHA HEL-S-281 FASN ALDOB HEL-S-30 PGM2 FBP1 ENO1 DLD ACADSB PFKL HEL-S-87p MCAT HEL60 HEL-S-162eP HEL-S-49 GYS2 ACADL ACADVL ENO2 SUCLG1 MLYCD SUCLA2 ACSL3 PYGL OXSM PMC6533081__F8 Proposed model of the regulation of erythropoiesis by heme and the HRI-ISR pathway during ID EPO ATF4 ATF5 GRB10 PMC9085237__F1 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties ABCC3 EGFR WNT1 CD44 CDK6 HMGA2 TSC2 TSC1 ATM MDM2 NOTCH1 SRC CCND1 AXIN2 AXL PMC4844615__F3 Pathogens-induced TLR signaling cascade in innate immune cells may exacerbate autoimmune diseases IL16 TLR4 FOS TRAF6 IRAK4 MYD88 TIRAP PMC11281666__F9 Deoxynivalenol and Its Acetylated Derivatives on Lipid Metabolism in Human Normal Hepatocytes LYPLA1 PLAAT3 PC LPCAT3 PLA2G4B PNPLA6 GPCPD1 PEMT PMC4471389__F1 Therapeutic potential of targeting IL-17-mediated pathway TH IL16 TYK2 IL23R PMC8359813__F1 Improving the Production of Riboflavin by Introducing a Mutant Ribulose 5-Phosphate 3-Epimerase Gene in Bacillus subtilis HEL107 RPE PMC3383194__F7 The mechanism through which PTPN22 blocks proapoptotic and enhances antiapoptotic BCR signals BCR BASH CD22 LYN SYK PLCG2 PTPN22 PMC9599067__F3 Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review ZNRF3 RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC3098994__F1 Genetics of Mechanosensation in the Heart FHL1 HEL-S-28 NBR1 PMC3953715__F1 PI3K/PTEN–mTOR pathway PTEN RHEB PMC8584958__F3 Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling UBC UBB PMC4022192__F5 TLR-induced signalling pathways TLR7 TLR4 IRF7 IRF3 MYD88 TLR1 TIRAP PMC4551270__F6 Genome sequence-derived metabolic reconstruction of Pyrobaculum yellowstonensis strain WP30 HBD FH ALB POR FADD PMC8942669__F3 Histone Methylation and Oxidative Stress in Cardiovascular Diseases COX2 SUV39H1 KEAP1 NOX4 TXNIP EZH2 SP1 KDM5A PMC7132142__F7 Schematic representation depicting the role of KMO in MM (a) pDCs trigger growth, survival, and drug resistance in MM cells IDO1 HAAO PDC KYNU KMO PMC6156496__F4 Core interactions between the mTOR pathway and Alzheimer's disease TFEB ATF4 EIF4E HIF1A MTHFD2 FOXO1 RHEB PMC10948527__F2 SHP2 signaling pathways: SHP2-dependent signaling in both developing and established cancer cells is illustrated, with arrows denoting positive regulators and T-bars indicating negative regulators GAB2 KSR1 GRB2 CCND1 SRC MTOR IRS1 PMC2955882__F4 ENaC and ASL volume regulation CFTR PMC5354077__F8 From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma DAO MAL PMC4686384__F5 Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins RAB5A MORF4L1 BTRC SLC25A44 RAB22A KLF5 RAB31 RPL15 FBXW11 FBXW7 PABPC4 FAF1 RAB5B AQP3 PABPC1 FAF2 KLF2 KLF9 PMC5036360__F9 CXCL3-induced signaling pathway in adipocytes IL8RB CXCL3 HEL-S-104 PMC3484277__F1 Downstream signaling of the IGF-1R TSC2 IGF1 IGF2 GRB2 PTEN MTOR IRS1 RHEB PMC10948527__F4 Immune cell-specific roles of SHP2 IL10 CD47 IRF8 APC BTLA TIGIT MTOR IFNG ITK SIRPA CSF1R ZAP70 CXCL9 HOXA10 CD226 CSF1 CD24 PMC3484277__F2 Insulin like growth factor (IGF) and insulin receptor (IR) signaling system IGF1R IGF1 IGF2 MTOR IGF2R PMC8841479__F4 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics MDM2 LATS1 RAF1 LATS2 PMC8841479__F1 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics NF2 AREG LATS1 ITGAV PMC2635340__F2 Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway PLAT APC PIR PMC4496485__F2 STAT3 signal transduction pathway SOCS3 SRC TYK2 STAT3 PMC5085760__F1 Major protein cascade and miRNAs in insulin signaling pathway MFN2 PMC11394629__F1 Genetics of BCC SUFU SHH SMO PMC11048531__F2 Combination of DSF/Cu and chemotherapeutic drugs sensitizes breast cancer (BC) cells and their stem cells by targeting various cellular and signaling mechanisms PGP CD44 STAT3 BAX CD24 FOXP3 PMC11394629__F2 Action of Hedgehog Pathway Inhibitors SUFU SHH SMO PMC3718700__F4 Presenilin functions PAN2 HEL-S-11 APP CCND1 PMC9061914__F6 Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles DCN CTSK opn TGFBR1 THBS1 HEL-S-7 HIF1A VEGFB TGFB1 HEL-S-133P COL10A1 COX5A PMC4995089__F4 Immune evasive attributes of SpA CD40 RIPK2 PMC3886260__F2 Lck is a central node in the T cell receptor signaling pathway CSK LCK PMC7935273__F8 GABA/Beta-glucan supplements on melatonin and serotonin content extracted from natural resources SP1 FOXO1 PMC6488418__F4 Figure 2.CD36 redox signaling in vascular smooth muscle cells, microvascular endothelial cells, and monocytes/macrophages HEL-S-2a FYN KEAP1 SYK CD36 PMC12034699__F6 Expression trends of each molecule associated with the interferon signaling pathway based on gene chip analysis The interferon signaling pathway was significantly activated IRF9 PIAS1 TYK2 IRF-1 PSMB8 SOCS1 IFNG BAX PMC8707654__F6 Metabolomic Profiling of Blood-Derived Microvesicles in Breast Cancer Patients PC LPCAT2 PMC12042829__F1 Annexin A regulates regulated cell death patterns such as autophagy, ferroptosis, and pyroptosis NLRP3 HMGB1 NLRC4 TFRC MTOR AIM2 DKFZp686F0183 GSDMD STAT3 PMC12164893__F1 Klotho protein-mediated network of signaling pathways FGF21 FGF23 PF4 FGF19 PMC11024688__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of the PI3K-AKT (A, B) and mitogen-activated protein kinase (MAPK) (C, D) signaling pathway was mapped by fold changes EGF BAD MEI1 TRADD FLNA PTEN TNF IRS1 RHEB RXRA MAX BCR JUND SYK TRAF2 MEF2C RBL2 PMC6945546__F3 Future treatments for HHT ANGPT2 BMP10 SRC ENG PTEN SMAD1 DKFZp781O1323 SMAD9 PMC6945546__F1 Mutated genes in HHT encode members of the BMP9/BMP10 signaling pathway BMPR2 BMP10 ENG PMC4740301__F3 Monocyte genes associated with the ML ratio are enriched for genes in the interferon signalling pathway IRF9 PIAS1 TYK2 JAK1 IFNG BAX PMC8832734__F1 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview GSK3B PMC8832734__F2 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview YBX1 TUG1 PMC6341270__F1 Mechanism of Nrf2 activation and Nrf2-mediated antioxidant responses in the lungs MAF KEAP1 RBX1 PMC4023363__F1 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities TSC2 ULK1 EGR1 BAD TFEB FKBP5 PTEN GRB10 MTOR RHEB PMC5665033__F8 How arecoline affects glycolysis and the signaling pathway of anoikis in HA22T/VGH cells ARHA HK2 PMC10809359__F7 PPI network of the signalling molecules regulating macrophage activity and HIF-1 signalling pathways FES RPL35 BLK RPS16 HMOX1 RPL8 ITGAM TIMP1 MMP2 CD177 RPS6 IL4 ARG1 RPS12 HEL-S-281 PMC7668240__F3 Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation PPM1E HSP90AB1 ACACA CACNA2D1 CLU CHEK2 CADM1 SMARCA4 AHR POLA1 GC LPL PKLR CDK4 APOE RBL1 FASN SNCA FGA PDE3B SYT13 CDKN1B STXBP1 HEL-S-53e MCM7 RRAS2 RAB3B SMARCE1 LIPE PAK1 VAMP2 CDK2 TRH DHFR PFKFB2 SYT7 HEL-S-72p CPLX2 CP PMC4547013__F1 Network of miRNAs and target genes in OS IGF1R RUNX2 ROCK1 EGFR MYC ARHA PTEN E2F3 DTL STAT3 PMC7667664__F2 Efferocytosis in health and disease CD47 ADAM9 EPO ARHA MERTK TNF PPARG ADAM17 CD36 PMC5842195__F2 Cell cycle arrest signaling CDK2 CDK4 CDC2 CDK6 PMC7667664__F3 Efferocytosis in health and disease COX2 CD47 AXL RANBP9 PMC7667664__F1 Efferocytosis in health and disease ADGRB1 RAC1 MERTK PBX1 ABCA1 SGK1 ELMO1 PMC4317307__F7 Proposed models of adiponectin metabolic pathway and associated genes ADIPOR1 COX2 ADIPOR2 IL18 IL4 APPL1 PMC8148450__F5 Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways BRAF CYC1 PTEN CAD ATR JUN LAT MAL PMC3705163__F8 Schematic model indicating proposed mechanisms by which mutant p53 GOF induces EMT KLF4 BMI1 PMC9493169__F4 Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect NLRP3 BTK TLR7 IL8RB CCL2 MYD88 IL1B PMC4074399__F1 Cell Death Pathways TRADD APAF1 TRAF2 FADD BAX PMC3713357__F1 Possible pathways for growth factor mediated tumorigenesis HEL-S-11 MTOR PMC5306231__F2 Possible cell-cycle checkpoint pathways in centrosomal (centriolar) integrity or morphology PLK4 USP28 NDEL1 PMC7312607__F7 Enriched pathway maps PDE4D GRIP1 FOS RHO CEBPB IFNG NFKBIA UNK HDAC2 FKBP4 JUN ADRBK1 STAT3 SUMO1 PMC5390895__F7 Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice FGFRL1 RXFP4 GPRC6A HEL-S-28 FCGBP RXRG HEL-S-310 RGS2 GAST NR1C1 PRKD1 SOX7 PCSK2 MAPK6 BCR TXN2 TIFA CRTC2 RPL10 SESN2 PMC4342024__F9 GPCR-mediated PLC/PKCB/PKD/SSH2 signaling pathway to regulate cofilin activity PLCB2 PLCB3 SSH2 PMC6721501__F2 Figure depicts pathways that cross-talk with Hh pathway leading to its non-canonical activation EGF EGFR GSK3B SMAD4 SMO MTOR PMC2628375__F7 Hypothetical scheme of activation of the murine Hamp1 promoter SMAD4 SMAD1 STAT3 PMC6721501__F1 Figure depicts canonical hedgehog signaling pathway DHH IHH SUFU GLI3 GSK3B SHH SMO PMC8664074__F1 Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma (HCC) initiation and progression CXXC5 DGIC HPCAL1 TRIM7 KIFC1 FOXK1 USP11 TRIM26 FOXP3 PRMT1 SIRT7 TRIM32 USP14 TRIM50 PRMT2 SIRT5 NCAPG NEK2 FOXA3 KIF15 TRIM44 FOXR2 SIRT1 PCDH10 PMC7966997__F4 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) PRKCA EGF PRKCB MAP2K4 SOST EGFR GRB2 PIK3CA HRAS STAT3 PMC7721156__F3 Interaction of preimplantation factor with the global bovine endometrial transcriptome COX2 LTA BCR ATM LYN LBP LTB TRAF6 SYK LAT PMC5011655__F6 Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine BAD AGTR1 MMP9 PDE2A HTR5A PLN ADRA1B EDNRA PLA2G1B TRPC6 ADCY5 NOS2 HTR2A PLA2G2A PMC3276511__F2 Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location CCR2 CCL21 RALA CCL7 CCL2 CCR8 RALBP1 CCL3L3 CCL16 CCR1 IL16 FYN CCL13 CCR7 MAPK1 CCL8 PLAUR ROBO2 HRAS NCAM1 ROBO3 CCL20 CCL22 SAA2 XCL2 CCR3 CCR6 CX3CR1 CKLF SLIT2 CXCL13 CXCL16 CCR10 CCL17 CCL28 CCL27 PF4 FGF2 CCR4 CD44 LECT2 RAC1 CXCR3 CCL15 ENPP2 LCK ROBO1 SYK CCL18 DOCK2 CCL23 PMC7966997__F1 EGFR pathway (Qiagen Pathway Central) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) ME2 MAFK EGFR RAG2 APOE PMC7966997__F2 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) PRKCA EGF PRKCB MAP2K4 SOST EGFR GRB2 PIK3CA HRAS SHC1 STAT3 PMC7721156__F2 Interaction of preimplantation factor with the global bovine endometrial transcriptome CASP3 MAFK TES NRAP TNF FADD MLKL PMC9498798__F5 Gene Regulation during Carapacial Ridge Development of Mauremys reevesii: The Development of Carapacial Ridge, Ribs and Scutes BAMBI HHIP INVS SUFU APC SOST EVC BCL2 SKP1 SMO SPOP ADRBK1 PMC6613812__F1 PI3K/Akt pathway plays a central role in nutrient-mediated cell proliferation and growth TSC2 TSC1 MAP4K3 PTEN RHEB PMC2653092__F5 Basic Helix-Loop-Helix Factor Hand2 Regulates Autonomic Nervous System Development TH PHOX2A DBH PHOX2B HAND2 GATA3 PMC4754024__F1 Transcriptional regulation of IL-12p40 (IL12b) in antigen-presenting cells TLR4 TLR9 IRF8 IRF3 MYD88 ETS2 PMC7188049__F3 Role of ACE2 (angiotensin-converting enzyme 2) in the pathogenesis of coronavirus disease 2019 and the inflammatory response ATR ACE2 ADAM17 TMPRSS2 PMC9127157__F4 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer SOCS3 APAF1 MSC NNMT TRAF6 CXCL14 STAT3 PMC8964039__F2 Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases APP GDNF BDNF PMC9127157__F5 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer HOXA7 BRCA1 IFNG PMC4871813__F2 Schematic illustration of B-cell activating factor (BAFF) signaling pathway TRAF3 TRAF6 TRAF2 PMC8714130__F9 Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation MPO TNF IL1B PMC3899188__F1 Regulation of lysosome biogenesis and functions in osteoclasts CTSK TFEB PLEKHM1 SNX10 SYT7 OSTM1 ATP6V1C1 DKFZp686F0183 RAB3D TCIRG1 GNPTAB PMC7898550__F9 Schematic diagram describing the mechanism in the inhibitory effect of PQS on NR inflammatory injury NLRP3 TLR4 MYD88 PSD PMC3121598__F10 The interplay between leptin, IGF-1 and AB42 IGF1R IGF1 EBP IRS1 PMC12108893__F4 In malignant cells, the biosynthesis of fatty acids and cholesterol both use acetyl-CoA as the starting substrate LDLR ACLY HMGCR FASN CD36 PMC10976710__F4 Molecular connection between the mTOR signaling pathway and polyploid giant cancer cells: (A) The interplay between polyploidy, senescence and mTOR signaling CD44 IL6 MTOR PMC8700172__F1 Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives CYR61 EGF WISP3 IGF1R TWIST1 CCN5 CCN3 CDH2 TNF CCN4 CTGF BMP4 PMC6495097__F8 Model of the Action circSNX29 Competitively Sponging miR-744-Mediating Myoblasts Differentiation CDK2 NFATC1 CCND1 MYOG PMC5768893__F6 Schematic Representation of FGF4 Signaling Regulated by O-GlcNAc in ESCsPhosphorylated PKCζ, the active form, activates the MEK-ERK1/2 pathway by FGF4 stimulation FGF4 OGT GATA6 PMC9184702__F6 Effect of D-Met supplementation on the milk protein synthesis pathway EIF4A2 PI3 MTOR HEL-S-162eP PMC10931919__F1 Origins and intracellular sensors of self-nucleic acids promoting the IFN-I signaling pathway TBK1 CGAS TLR7 TLR9 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 TLR3 PMC8692837__F3 Mechanobiological Implications of Cancer Progression in Space LEF1 APC LRP5 LRP6 TCF4 EPHB2 EPHB3 PMC4028364__F1 Conservation of host cells and pathogen categories in zebrafish and mammalian infection by eukaryotes CXCL8 TNF IL1B PMC8891017__F7 Genetic associations of protein-coding variants in human disease F5 APC TF PMC2927928__F3 Molecular pathways involved in pancreas and liver differentiation from hES cells PDX1 PTF1A AFP ALB FGF2 FGF10 NKX6-1 SOX9 FOXA2 PMC4813275__F1 Pathways that represent potential targets for miRNAs in drug-resistant GC IHH IGF1R BCL2 SMO PTEN IRS1 PMC8145743__F8 CDDO-Me Attenuates Astroglial Autophagy via Nrf2-, ERK1/2-SP1- and Src-CK2-PTEN-PI3K/AKT-Mediated Signaling Pathways in the Hippocampus of Chronic Epilepsy Rats GSK3B PTEN SP1 PMC8395072__F3 Transcriptomic Analysis Reveals Key Genes Involved in Oil and Linoleic Acid Biosynthesis during Artemisia sphaerocephala Seed Development DAG1 PC LPA HEL-S-5 PMC3937033__F8 T cell PPI Network mapped to TCR, with main JAK-STAT and MAPK signaling pathways FYN LCK RELA EGFR ARHA REL LAT ICOS PMC3960190__F1 Perspectives of TGFB inhibition in pancreatic and hepatocellular carcinomas SMAD2 GRB2 SMAD6 SMAD4 TGFBR3 MTOR PMC2871322__F1 Schematic of central regulation of body fluid regulation in response to acute changes in sodium and volume AVP NTS LPO PMC12098375__F1 Regulatory mechanism of ERK1/2 signaling in promoting insulin secretion and insulin resistance EGF GRB2 IRS1 PMC2871322__F3 Schematic diagram of the forebrain neurocircuitry and peripheral inputs underlying the influences of osmotic and peripheral angiotensin II (Ang II) on sympathetic outflow and the baroreflex AVP NTS LPO PMC4554827__F1 Core of the Hippo pathway BIRC5 AMOTL2 AREG LATS1 MOB1A MOBKL1A LATS2 HEL-S-31 PMC6963216__F2 Cascade of events that leads to interferons (IFN) mediated antiviral response TBK1 STAT1 STAT2 IRF9 IRF3 TYK2 JAK1 IFNAR1 IRF-1 MAVS PMC6456803__F1 Vitamin D pathway TH CYP27A1 FGF23 NR1i1 DHCR7 CUBN DBP CYP24A1 PTH PMC11790448__F1 Adropin regulates multiple signaling pathways GPX1 LPL GPR19 ARHA PTEN PDK4 BDNF SIRT1 STAT3 PMC4554827__F3 Function of nuclear and cytoplasmic Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) NCOA6 CDC73 PMC4470732__F1 Scheme illustrating the ASARM-model and the FAM20C kinase link to the FAP pathway: The numbers highlighted in the circles refer to the explanations in the following text FAM20C FGF23 FURIN GALNT3 DMP1 PMC4554827__F4 Signal crosstalk with Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) NOTCH2 EGF ZYX AREG SMAD2 TBX5 NRG1 LATS1 DKK1 LATS2 LAMA5 PMC8804851__F8 Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway ACAN COL2A1 NQO1 PMC2898451__F8 Schematic illustration of signaling pathways involved in PDGF-mediated induction of Arc expression EGR1 ARC PMC3426114__F9 Two Possible Models Regarding the Role of CDT1 Proteins in Response to DNA Stress.(A) Downregulation of CDT1 upon DNA stress may be promoted by WEE1 and/or SOG1 WEE1 ATM ATR CDT1 PMC7105474__F3 Life, death, and autophagy in cancer: NFKB turns up everywhere RELA RELB TRAF2 PMC3813433__F1 Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management RICTOR MTOR PMC3475760__F1 As a key downstream target of PI3K-mediated signaling pathway in response to extracellular stimuli such as growth factors through receptor tyrosine kinase (RTK), Akt plays an important role in regulation of diverse cellular processes MDM2 PTEN PMC12121814__F10 Multifaceted roles of the small EV proteome in NP cell and tissue homeostasis HEL-S-87p HEL107 HEL-S-281 PMC8199608__F1 Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor CDK5 CD44 ARHA CDC42 PMC10759449__F8 Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway PDIA4 BAX PMC7913382__F5 Mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) pathway crosstalk, downstream effects, and inhibitors currently being trialled in pancreatic cancer treatment EGF EGFR GRB2 STAT3 PMC7913382__F6 PI3K/AKT/mTOR pathway in pancreatic cancer is central for cancer cell growth, survival, migration, invasion, angiogenesis, and modulation of the anti-cancer immune response TSC2 TSC1 TRIB3 GRB2 PTEN RHEB STAT3 PMC10932453__F2 Non-coding RNAs in the host response to M MAP3K1 FOXO3A FOS PTEN PPM1B SOCS5 JUN PMC10932453__F3 Immune response of the tracheal mucosa to M TLR4 CCL13 APC STAT4 IFNG PMC8508814__F1 Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy CA9 TF STAT3 PMC7690676__F2 Competing endogenous RNA (ceRNA) mechanisms and potential downstream regulatory mechanisms of NNT-AS1 CCND1 MMP21 BCL9 CDK6 PMC3847144__F1 Isoprenoid and amino acid biosynthetic pathways MVK IPP MVP PMC3161420__F1 Regulation of apoptosis by the BCL-2 family BAD BMF BAX PMC3355940__F2 K63-linked polyubiquitination in the activation of canonical and non-canonical NFKB signaling pathway CYLD IRAK1 CD40 TNF TRAF2 PMC4683180__F2 Tentative metabolic pathway model of membrane-bound electron transport in Methanoperedens MTR FH FES CYB PMC3340361__F1 RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans EGF EGFR GRB2 CBL PMC4716037__F1 Deregulation of Hippo pathway in gastric cancer TEAD3 YAP1 VGLL4 TEAD4 LATS1 LATS2 TEAD2 PMC4832581__F2 Cellular iron homeostasis and putative involvement of NBIA‐associated genes PLA2G6 FA2H FTL WDR45 C19orf12 COASY PANK2 CP DCAF17 PMC9019922__F5 DSPP signalling during dentineogenesis and dentine regeneration BMP1 SMAD4 DSPP SMAD1 TF DKFZp781O1323 PMC7184741__F6 Glyoxylic acid overcomes 1-MCP-induced blockage of fruit ripening in Pyrus communis L. var. ‘D’Anjou’ MTR GLA PMC4806539__F2 Biological networks according to IPA of 1370 genes related to HNSCC NFKBIA NFKB1 BRCA1 PMC6176484__F4 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer GSK3B SHH LRP6 SMO PMC6326357__F1 Role of MAIT cells in spondyloarthritis (SpA) RORC CCR2 CCR6 APC IL7R HEL-S-92n MR1 IL23R CXCR6 CD69 PMC6176484__F2 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer DKFZp781B1423 MDM2 CDK4 CDK6 PMC11809324__F7 Treg cell aging and regulatory role of PD‐1 in advanced‐age pregnancies DUSP4 PMC9326111__F6 Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer BAD TRPV6 MCU TRPV1 BAX PMC5722594__F1 Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer BCR ZAP70 SYK PMC5366313__F5 Representative view of the iNKT/innate CD8(+) T-cell axis hypothesis in chronic myeloid leukemia (CML) IL18 CD1D RHO PMC7286881__F10 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics LEP KIT REN CFD LCK TTN PMC10672974__F13 Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment PTEN MTOR IRS1 PMC7286881__F14 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics F10 THBD PROC NPC1L1 KCNMA1 CCL2 MTTP INSR PLAT IL18 HEL-S-78p TLR4 KDR NPY LPL VWF LEPR CD40LG THBS1 CHRM2 NOS2 NPPA TFPI PF4 PTGS2 TNF RXRA APOB LEP PLTP LTA RELA BCL2 ADRA1A TF TGFBI PMC6603234__F3 Outline of potential mechanism of sEH inhibition-stabilized EETs in inhibiting colonic adenoma—carcinoma sequence via targeting inflammation and its activated Wnt/mutant p53 signals COX2 APC DIO1 PMC5057284__F3 Circadian oscillations in intracellular organelle’s structure and function CRY1 NAMPT ULK1 ATM ATF4 XPA XBP1 PER2 FIS1 PER1 PMC8186902__F4 HIF-1 signaling pathway with overlay data from differential expression and reporter metabolites analysis TLR4 EPO MAFK PFKL HEL-S-87p HEL-S-133P IFNG HEL-S-162eP PMC7765462__F10 Scenarios of SK3-Orai1 interplay ORAI1 STIM1 PMC5650067__F9 Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells EGFR SRC PMC4805359__F4 Schematic representation of the proposed model to explain NHR-49/PPARA function in promoting the longevity of germline-less animals (modified from Ratnappan et al.,) KRI1 TCERG1 NR1C1 PMC8350166__F1 PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective APC PTEN MTOR STAT3 PMC6902900__F2 Overview of cellular metabolism in T cells TSC2 TSC1 FOXO3A MYC GCK CPT2 CTLA4 DEPTOR FOXO1 FOXP3 PMC8616823__F2 Cell communication involved in tumour establishment, invasion and immune escape TLR9 AHR CLEC2D GPR34 CCL2 TNF CR1 CHI3L1 PMC7369235__F8 Signaling mechanisms of BCR-induced CSR BTK BCR AID TRAF3 RELB CD40 SYK PLCG2 TRAF2 PMC10907606__F8 Hypothetical model showing the role of OAT in IPF pathogenesis SMAD2 PRODH SMAD4 PMC4887650__F1 TLR4 intracellular signaling pathways TLR4 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 MAL PMC4182113__F1 Interferons: Success in anti-viral immunotherapy STAT1 TYK2 IFNAR2 JAK1 IFNAR1 PMC7157451__F2 IFNA and IFNB bind to the type I IFN receptor (IFNAR) and activate the expression of numerous ISGs via the JAK/STAT pathway STAT1 ADAR STAT2 IRF7 ISG20 IRF9 IRF3 TYK2 JAK1 IFIT1 PMC3841209__F9 Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer BRAF EGFR ARAF PMC6263145__F2 Mitochondrial Quality Control in the Diabetic Heart ULK1 ATG12 ATG101 MTOR PMC6679985__F3 Circadian Clocks and Cancer: Time-Keeping Governs Cellular Metabolism MYC MLX PMC4849272__F3 Hepcidin antagonists ERFE SMAD4 HFE SOSTDC1 TF TFR2 STAT3 PMC12174671__F3 Simplified visualization of NAD+ production pathways NAPRT NAMPT HEL-S-90n NMNAT1 NMNAT2 NMNAT3 PMC3710659__F9 The proposed signaling pathways for 8-iso-PGF2Alpha-mediated modulation of human platelet function TPR ARHA RHO PMC5511860__F6 BMP-2 induced EMT and breast cancer stemness through Rb and CD44 signaling BMP2 CD44 SMAD1 PMC5479927__F1 CoQ biosynthesis and effect of 4-HB analogs TH COQ3 COQ2 COQ6 COQ5 ALDH3A1 IPP COQ7 PMC3945521__F7 TRIMmunity: The roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity TBK1 IFNA1 IRF8 TRAF3 DDX41 ECSIT TLR3 TAB3 PMC3022513__F1 Physiological regulation of the mTOR signaling pathway TSC2 PTEN EIF4E MTOR RHEB PMC8324684__F3 Metabolic-associated fatty liver disease and lipoprotein metabolism TM6SF2 APOB TG MTTP PMC10886332__F3 Co-expression network for the PP group based on lncRNA key regulators NOCT COMP PMC7906148__F4 Analysis of 219 hub genes with degree ≥10 HEL-S-7a MYB CTSK EFNA1 BMP2 WNT7A PTGS2 EFNB2 SEMA3B IRS1 CFTR TNC DLL4 FOSB NCF1 SOCS1 NCF2 PMC8869528__F1 Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC10467107__F7 Cardiac Toxicity Induced by Long-Term Environmental Levels of MC-LR Exposure in Mice MTOR TF TGFBI PMC9646898__F4 Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance TRADD FOS TRAF1 TRAF3 TRAF2 JUN FADD ADAM17 TRAF4 PMC8145841__F2 Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs FECH UROD UROS CPOX PMC2757699__F1 Metabolic fate of the 13C-label from [1-13C]-glucose HK2 PMC5288170__F1 Molecular mechanisms of OLIG2 transcription factor in brain cancer PTCH2 TCF3 FGF2 ARHA OLIG2 FGFR2 CDK6 PTCH1 MDM2 OLIG1 SHH SMO CDK4 PMC5067332__F1 Inositol mechanisms of action in cancer cells ROCK2 EGF ROCK1 INS PMC5676473__F1 Schematic diagram of Nrf2 signaling and regulation in the corneal epithelial cells KEAP1 NOX4 NQO1 PMC3831179__F15 Pathway Commons (accessed through Cytoscape) SMAD2 SMAD6 SMAD4 SKI SMAD1 DKFZp781O1323 PMC3012148__F2 Biosynthetic pathway of sphingolipids that mediate expressions of genes associated with cellular processes in cancer FGF4 CS LEFTY1 EGFR GFAP PTEN ZNF580 CCND1 CDK4 TXNIP CERK STIM1 BAX PMC6798356__F2 COPD creates a favourable microenvironment for lung cancer initiation and progression SET TNF S100A4 PMC3562183__F2 Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle-Invasive Bladder Transition Cell Carcinoma BRAF ARHA NCK1 NF1 VEGFC VAV3 FYN CDK2 GRB2 CAV2 JAK1 SKP2 AKT3 PMC4055784__F2 The interactome space of the edible plants associated to colon cancer ACHE RAN GRAP PMC5528323__F6 Pathways of steroid hormone synthesis, metabolism and tissue sensitivity to HRT (Kelemen et al., 2008; Pasqualini and Chetrite, 2005; Masson et al., 2010) MiRNA's predicted to target steroidogenic or metabolizing enzymes are encased in blue CYP1B1 PGR EGFR HSD17B1 HEL-S-130P CYP1A2 CRYZ CCNE1 SULF1 CDC20 CYP3A4 ERBB2 CYP17A1 CCNE2 PMC4774640__F3 Schematic representation of the ectoenzymes and transporters involved in the extracellular ATP metabolism ENPP1 CFTR PMC11347096__F5 Schematic diagram summarizes the regulation of lipid metabolism in normal or malignant B cells BTK CARD11 BCR UGCG MYC SRC SPHK1 PTEN MYD88 SPHK2 FASN PMC3035871__F2 Targeting Fas in osteoresorptive disorders RUNX2 BMP2 NFATC1 FOS ATF4 LRP5 SMAD4 ARHA SYK SMAD1 JUN EPHB4 PMC11347096__F6 Schematic diagram summarizes the potential therapeutic targets of different lipid species and related pathways to treat inflammatory disease or B cell malignancy BTK BCR UGCG MYC HDAC2 SPHK1 MTOR SPHK2 HDAC1 PMC11347096__F3 Cholesterol metabolism is necessary to defend against foreign antigens BTK BCR IFITM3 ABCG1 SRC SYK MYD88 ABCA1 MTOR HMGCR CD19 PMC11347096__F4 Sphingolipid metabolism DES CERK SMS PMC11347096__F2 Phospholipids and their binding proteins mediate normal or malignant B cell activation BTK CARD11 BCL10 BCR SRC SYK PTEN CD19 PMC4859980__F1 HSV modulates apoptosis signaling CASP3 TRADD CASP9 TNF CASP8 FADD LAT PMC2909319__F9 Model: a Src-Tks5-Nck signalling pathway in invadopodia PI3 GRB2 SRC PMC3104012__F1 Summary of the common pathways underlying neurodegenerative diseases and cancer that are mediated by miRNAs BACE1 BRMS1 MYC PTEN DNMT3B CDK6 BCL2L2 CASP3 NAV3 ATM PITX3 APP MCL1 PMC6025008__F4 ER stress and the UPR in insulin resistance and diabetes VLDLR ATF4 EIF2A IL6 XBP1 IAPP PMC5380946__F1 TRIM38-mediated negative regulation of TLR3/4-mediated and TNF/IL-1-triggered signaling TBK1 TANK IRAK1 TRAF3 TRAF6 IRF3 IL6 MYD88 TNF MEX3B TLR3 TLR4 TRIM38 IL1B TAB3 PMC5940409__F7 Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells IGF1 ATM CCND1 STAT3 PMC3831179__F14 Pathway databases EGF FOS GRB2 JUN STAT3 PMC5380946__F2 Sumoylation promotes the stability of cGas and Sting and regulates the kinetics of the response to a DNA virus TRIM38 IRF3 SENP2 PMC1573858__F1 AT1 receptor signal transduction pathways that result in transcriptional NA neuromodulation (a) and increased firing rate (b) in neuronal cultures TH FRK FOS DBH JUN PMC10178434__F2 D+ synthesis pathways NAPRT NAMPT NMNAT1 NMNAT2 NMNAT3 PMC10607347__F3 The anti-apoptotic action of MSCs in the hepatocyte–MSC co-cultures PIM1 HGF MSC PTEN MTOR HK2 BAX PMC4961213__F3 IFN-induced Guanylate Binding Proteins in Inflammasome Activation and Host Defense STAT1 CAP2 IL18 STAT2 IRF9 GBP2 GBP5 GBP3 AIM2 IRF-1 GSDMD PMC8101356__F6 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism KAT2B NUMB NPPA LAT2 UBA3 BCL2L11 CHD3 LTA IGF1 RELA ITGAX CR2 MAVS ALPI TCF4 CDC42 PMC4407539__F8 Predicted model of the immune response of Epinephelus coioides larvae to V HEL-S-62p C4B_2 MASP1 C7 C6 C1S PMC8101356__F5 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism VASP SET MAP2 DBN1 CCR3 SSH2 WAS PTEN RHO GIT2 EPHB4 PSD PTPRC ARHG HEL32 ITSN2 SSH3 SSH1 CDC42 MAL PMC3982149__F6 Antibody against CD44s Inhibits Pancreatic Tumor Initiation and Post-Radiation Recurrence in Mice SOX2 CCND1 H4C9 STAT3 PMC7048745__F2 Ubiquitination in tumor metabolism regulation USP4 OTUD7B TBC1D7 TRAF6 PTEN WWP1 MTOR OTUD3 FBXW7 FBXL12 TTC3 HERC1 SENP7 CYLD MDM2 USP37 NPRL2 SENP1 VHL RNF152 KLHL22 DEPTOR IRS1 RHEB MLST8 TSC2 RICTOR PIAS1 USP36 TRIM28 TRIM24 TRAF2 SKP2 PMC7048745__F3 Ubiquitination in immunological tumor microenvironment (TME) modulation TBK1 CGAS TANK MIB1 TLR9 USP21 TRAF3 TRAF6 MYD88 TLR8 RNF5 AMFR TLR7 IRF7 DTX4 IRF3 PELI1 TRIM25 MAP3K7IP1 TLR3 TRIM23 RNF125 TRIM38 TRIM32 TRIM56 MIB2 MAVS ITCH PMC9106713__F1 Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway FDX1 ATP7B FES SLC31A1 DLAT PMC9468207__F6 Meta-analysis highlights the key drought responsive genes in genes: PEPC and TaSAG7 are hubs response networks REN SI DES ENG PMC8999052__F6 Wide-Proteome Analysis to Identify Molecular Pathways Involved in Kidney Response to High-Fat Diet in Mice HEL-S-102 MAP2K1 SET MAP2 SSR4 RPSA YWHAG pcap PYGL GCSH PMC7032688__F5 Wolbachia limits pathogen infections through induction of host innate immune responses TRAF2 FADD PMC10674663__F7 Comparative Analysis of Cd Uptake and Tolerance in Two Mangrove Species (Avicennia marina and Rhizophora stylosa) with Distinct Apoplast Barriers MYB HP PMC7739442__F1 Inborn errors of immunity conferring predisposition to childhood HSE DBR1 TBK1 STAT1 STAT2 IRF9 TRAF3 IRF3 TYK2 JAK1 TLR3 PMC11742494__F7 CHI3L1’s role in the pathology of Alzheimer’s disease through modulation of neuroinflammation TNF CHI3L1 STAT3 PMC7158159__F6 Detailed signaling pathway of G-protein coupled receptor GRK4 FYN SRC STAT3 PMC7046483__F3 RANK/RANKL/OPG pathway in fatty acids‐modulated bone metabolism RUNX2 SRC TRAF6 JUN PMC7483535__F7 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration BAD MOS NFATC1 SRC DOCK1 EIF4E CRK ARAF PMC4369651__F1 Methotrexate pathway GGH DHFR TYMS HEL-S-70p FPGS SLC19A1 PMC7483535__F8 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration DRD5 DDC DRD2 CALY PMC3260552__F4 Melanoma signaling networks, progression, and influences by the BCL-2 family BAD PTEN MCL1 BMF BAX PMC4143829__F1 Model expressing the distinct molecular pathways of ER transcription factors regulatory actions EGFR SRC TF PMC7607069__F9 TP53 signaling pathway via cBioPortal DKFZp781B1423 MDM2 CDKN2A PMC11742494__F2 CHI3L1-induced tumor angiogenesis, growth, migration, invasion, and inflammation IL13RA2 SMAD2 MMP9 CD44 CXCL8 CHI3L1 PMC6789471__F4 Protein–protein interaction (PPI) network of the set of DEGs/DEPs identified in the overrepresented GO Immune System Process terms BRAF RNF31 HEL-S-99n MYC NCF4 PSMB3 PRKCA PSMD7 DACT2 JUN ACTR2 MAFB CDC37 RNF4 CACNB3 TRIM25 TOB2 AP2S1 TNFSF11 WIPF2 CSA2 PSMD4 PYCARD FADD MLL2 PIK3R2 PMC7769847__F2 Schematic summary of Osx’s mission in the complex communications among different bone cells and its potential role in bone micro-environment AIP NFATC1 SOST MMP9 COL1A1 DMP1 PMC4358097__F11 Plasma treatment abolish siRNA-induced knockdown of NRF2 KEAP1 JUND CSF2 HMOX1 JUN NQO1 BACH1 PMC7769847__F3 Overview of crosstalk pathways associated with Osx ENPP1 RUNX2 SOST ZBTB16 LRP5 LRP6 MSX2 DLX5 COL1A1 GRP PMC3675380__F2 Synergy between TCR/CD28 and TNFR signalosomes for activation of the PI3K-Akt pathway in T cells BCL10 APC GSK3B CD80 PMC9027994__F1 Proline Metabolism in Malignant Gliomas: A Systematic Literature Review PYCR2 PRODH PMC8697421__F3 Type I IFN immunity in viral pneumonia TBK1 STAT1 STAT2 IRF7 IRF9 UNC93B1 TRAF3 IRF3 IFNAR2 IFNAR1 TLR3 PMC8697421__F1 Inborn errors of immunity underlying severe cutaneous HPV infections PIK3CD PIK3R1 MAGT1 IKBKG ARHH DOCK8 HEL-S-92n WAS ITK CARMIL2 CARD11 CXCR4 LCK STK4 ZAP70 CD80 LAT PMC3509894__F3 Vitamin B12 Synthesis and Salvage Pathways Were Acquired by Horizontal Gene Transfer to the Thermotogales APP CBL PMC3675380__F1 Tumor necrosis factor receptor family molecules that possibly activate the PI3K-Akt pathway in T cells LTA CD27 TRAF5 TNLG8A TRAF1 TRAF3 TNF TRAF2 PMC10834974__F5 Novel preliminary metabolomic panel for IHD diagnostics and pathogenesis HEL-S-62p C6 PMC6980368__F2 S1P signaling in HCC progression MMP7 HGF S1PR1 SPNS2 TRAF2 PMC9340492__F1 Zebrafish models of inflammation in hematopoietic development and disease TBK1 FLI1 RUNX1 IRF9 LYN SYK IL6 JAK1 IL1B IFNG GATA2 PMC7996784__F2 Mevalonate and methylerythritol 4-phosphate pathways in Cannabis sativa ME2 MVD IPP PMC9359975__F6 Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1A signaling pathway TWIST1 ZEB2 PMC8827057__F8 Overview diagram describing the mechanism of the inhibitory effect of HF-MSCs on HSCs SMAD2 SMAD4 PMC6945783__F1 Scheme of the functional patterns within the glycolytic pathway in beta cells in health and type 1 diabetes GCK HEL-S-133P PMC6791856__F8 Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation NLRP3 HMGB1 PMC5552660__F1 Cholinergic anti-inflammatory pathway (CAP) NTS TNF PMC8636596__F3 Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway TBK1 IRF3 MAVS PMC8469138__F4A Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis CPB2 C8A PLTP TCAP CD2 MYC C4BPA CFP TTN CD3G IL2RB CFI PMC6411824__F1 Overview of the Nrf2 pathway activation MAF RAC3 KEAP1 RBX1 RXRA PMC8827057__F1 Experimental design AFP SMAD2 ALB PMC5414761__F8 Proposed mechanism for GDNF-induced proliferation of mesenchymal and epithelial cells in the UGS RET GDNF PMC2886808__F1 Signalling through growth factor receptors can activate the PI3K/Akt/mTOR pathway and the JAK3/STAT5 pathway JAK3 MTOR FOXP3 PMC9949995__F2 Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury DHFR FOLR1 PMC6904864__F1 Small molecules guiding mesenchymal stem cell osteogenic cell fate determination IGF1 SMAD1 PMC5941175__F4 Kinetic reaction schemes of GroEL–GroES interaction revealed by HS-AFM imaging under different substrate conditions FBL SI FH PMC9009033__F3 ARID1A variations in colorectal cancer: a collaborative review ARID1B PLK1 APC PIK3CA ARID2 MTOR FBXW7 AURKA ARID1A ARID4A PMC4546755__F1 Known regulatory mechanisms of NRF2, highlighting miRNA-mediated influences AHR CDKN1A KEAP1 NQO1 PMC4546755__F2 Overview of ROS-mediated NRF2 activities KEAP1 TXN NQO1 PMC4546755__F3 Overview of carcinogenesis and NRF2 responses KEAP1 PMC8020867__F1 Map of net odds () for reactions of glycolysis and the tricarboxylic acid (TCA) cycle GOPC RPE PMC7443379__F8 Molecular and cellular basis of left–right asymmetry in vertebrates DRAP1 LEFTY1 NODAL PITX2 SMAD2 LEFTY2 GDF1 FOXH1 PMC8371750__F7 Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study CASP3 CASP9 CDK6 PMC8997421__F1 MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology AGO1 AGO2 AGO4 DROSHA PMC2996483__F3 Oncogenic Notch1 Signalling IL7R PTEN MTOR PMC6720712__F7 Diagram illustrating the underlying mechanism by which that miR-15a regulates the differentiation of chicken intramuscular preadipocytes by targeting ACOX1, SCP2 and ACAA1 in the PPAR signaling pathway ACOX1 PMC7556779__F5 Evasion of the Pattern Recognition Receptor-Type I Interferon (PRR-IFN-I) Pathways by Coronaviruses (CoVs).A simplified schematic of the canonical IFN response after sensing RNA viruses TBK1 STAT1 CGAS STAT2 IRF7 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC9681554__F9 Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury NLRP3 ARG1 GSDMD PMC7617722__F3 Fatty acid metabolism and its regulation by E5, E6 and E7 encoded by HPV oncoproteins EGFR ACLY FASN HEL-S-5 PMC3711381__F1 ERK pathway, its upstream activators and downstream targets EGF EGFR RAF1 BDNF PMC3711381__F3 Htt affects ERK signaling in multiple ways EGF HTT BDNF PMC8891382__F2 Tumor Immune Microenvironment and Immunotherapy in Brain Metastasis From Non-Small Cell Lung Cancer EGF HGF MMP2 CX3CL1 MMP9 CCL21 CD80 PTEN TNF MTOR IL1B PMC9370344__F10 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants ACCS PDC ERF PMC6044347__F2 The steroidogenic pathway LDLR CYP11A1 CYP17A1 PMC9077970__F4 Dual role of autophagy in acute myeloid leukemia TFEB MTOR FASN PMC11357512__F2 Signalling pathway in a cardiomyocyte with lamin A/C variant factors such as pERK1/2, pSmad1/2, and TEAD1 affect the gene expression of LMNA mutant cells TRPV4 CAMK2D RYR2 PMC9077970__F1 Dual role of autophagy in acute myeloid leukemia DRAM2 DKFZp686F0183 PMC9077970__F2 Dual role of autophagy in acute myeloid leukemia PML HEL-S-26 ULK1 RET TFEB ATF4 MYC FLT3 WWP1 DKFZp686F0183 SIRT1 STAT3 PMC2849704__F1 Homocysteine metabolism in liver and kidney HEL-S-61p PMC6548405__F7 CBX2 is required to stabilize the testis pathway by repressing Wnt signaling CBX2 LEF1 SOX9 PMC7042394__F1 Core components of the Hippo pathway in Drosophila and mammalian MOB2 LATS1 PMC4987730__F7 Antibody-mediated blockade of the PS signaling pathway in the tumor microenvironment TYRO3 CD300A PMC4460803__F2 Recently identified drivers in signaling pathways involved in adrenal tumorigenesis ZNRF3 LRP6 ARMC5 CYP21A2 STAR PMC5538796__F1 Endothelial cell metabolism in health and disease: impact of hypoxia CPT1A PROX1 PMC11005695__S1 Thermosensitive Bi‐Adjuvant Hydrogel Triggers Epitope Spreading to Promote the Anti‐Tumor Efficacy of Frameshift Neoantigens TBK1 CGAS TLR7 NHS IRF7 TRAF6 IRF3 PMC5791813__F1 Interplay between Nrf2 and Brf2 pathways KEAP1 PMC3773983__F2 Four major signaling pathways in the postsynaptic region of a neuron that combine to form a local signaling network GRB2 MAPK1 BDNF PMC10804064__F2 Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites PMVK MVK IPP PMC7573470__F1 Life cycle of SARS-CoV-2 and its possible inhibitors ACE2 TMPRSS2 HEL-S-69p PMC7168252__F1 Beclin 1 function in autophagy and the role of its post-translational modifications implicated in cancer ULK1 BCR EGFR ATG101 UVRAG ATG14 PMC2649086__F7 KLF14-mediated TGFBRII silencing KLF14 SIN3A SP1 PMC4803136__F1 The biologically relevant candidate genes selected in this pharmacogenomic study ADORA2A GGH SHMT1 DHFR EEF1A1 TYMS IL2 MTHFD1 HEL-S-70p FPGS SLC19A1 PMC11202552__F2 Simplified diagram of the insulin signaling pathway PDE3B RAC1 FOXO1 PMC4957599__F2 Molecular mechanism of disc cell senescence ATM CDK2 CDK4 MTOR ATR CDK6 PMC4880142__F6 Exposure of MCF-7 cells to 10 nM E2 (A) and 1 μM G-1 (B) induced phosphorylation of proteins involved in cellular processes associated with cell cycle although the specific phosphorylation profiles varied NDRG2 MARCKS NPM1 ALK PARD6B MYC PAK4 MARK1 AKT1S1 SUDS3 UNG EIF5 PYGO2 GORASP2 SEC31A DFFA EAPP SRPK1 EBAG9 CAD BAG3 YBX1 HEL-S-34 MAP2K2 SCRIB NMT1 TRIM25 OGFR G3BP2 ZNF217 KPNA2 TPD52 RAF1 PMC8718269__F4 Functions of PARP5a/b, PARP7, and PARP9 in viral infection TBK1 DTX3L STAT1 IRF7 EXOSC5 PARP1 IRF3 AKT3 PMC8492287__F6 Novel Identified Peptide Hormone “Metabolitin” Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway NR1C1 CD36 PMC9932084__F10 Work model of 181-Rik function in the mitochondria-mediated inflammatory response of microglia NLRP3 STMP1 UCP2 GSDMD PMC3494185__F7 Hypothetical schematic of the roles of KPNA2 and E2F1 in NSCLC JMJD6 POLA1 POLA2 KPNA2 UGDH MCM10 DBF4 PMS2 PMC6880611__F1 Insulin signaling and insulin resistance in MetS and skin diseases TSC2 GRB2 PMC7248199__F7 Putative pathway showing regulatory relationships of key genes to NFKB activation transcriptionally regulated by NLRC5 TLR5 TLR7 IRF7 IL2 CCL5 LITAF IL5 CASP8 GATA3 STAT3 PMC7278913__F3 SMAD4 loss and potential therapeutic strategies in SMAD4 signaling SMAD4 HEL-S-68p PMC3380218__F1 The Drosophila IMD and mammalian TNF signalling pathways TRADD RELA REL TRAF2 CASP8 FADD PMC4430528__F5 Sharing and Specificity of Co-expression Networks across 35 Human Tissues CD9 KCNA3 RUNX3 GIPR SEMA4C TIGIT CCND2 ITGB7 LCK ZAP70 PZP FMNL3 NLRC3 LY9 LBH GATA3 IL2RB PMC4513088__F8 Proposed signaling pathways of PS1-induced apoptosis CASP3 CASP9 BCL2 PSAP DIABLO FADD BAX PMC7088895__F1 TGFB and BMPs signaling pathways SMAD2 SMAD4 MTOR SMAD1 DKFZp781O1323 SMAD9 PMC9942973__F9 Working model for HCMV-induced SOCS3 upregulation in NPCs SOCS3 RFX7 LIF PMC12206628__F6 Signaling pathways of NK cell-mediated cytotoxicity and apoptosis HMGB1 HLA-E PLCG1 PF4 GSK3B HAVCR2 IFNAR2 IFNAR1 HLA-C KIR2DL1 PAK1 FYN RFFL MAP2K1 STX4A PTPN11 STK4 HDAC2 PRF1 THBS1 TNFRSF10A KIR2DL4 MAVS PMC4862578__F1 Illustration of negative regulators of CaN-NFAT signaling pathway in cardiac hypertrophy CHP2 CHP1 RCAN3 FHL2 RCAN1 PMC8292061__F5 Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis KIT NR3A2 ALK EGFR VEGFA INSR IKBKB MMP2 F2 SRC CDC2 FLT3 CDC42 TERT PMC3697783__F8 Wnt signaling pathway NLK APC PROC LRP5 SMAD4 LRP6 SKP1 RBX1 PMC7028010__F1 UPR activation mediates beta-cell survival ATF4 EIF2A TXNIP XBP1 STAT3 PMC6901278__F3 Regulatory network hubs are related to neurogenesis NOTCH2 GAD2 RELN MIB1 DNER SEMA3A NPAS3 PAFAH1B1 WNT7A EGFR LFNG PTEN SLIT3 GIG8 PLXNA4 CDH4 NOTCH1 NPAS1 CALB1 ADAM10 TBR1 WNT7B APOE PMC5966770__F2 Biosynthesis and consumption of NAD+ NAMPT HEL-S-90n NMRK2 NMRK1 PNP PMC3278831__F4 Sample subnetwork formation ATM MDM2 RHO PMC7731343__F7 Differentially expressed protein (DEP) expression in the plasma of rainbow trout exposed to thermal stress HEL-S-62p HEL-S-78p PS1TP5BP1 PMC9141839__F7 Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1/p53 Pathway CDC20 ESD CDCA8 PMC9547461__F2 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy NLRC4 TRADD NLRP1 RIPK3 TNF ZBP1 GSDMD RIPK1 TRAF5 APAF1 TRAF2 CASP8 FADD MLKL BAX DFNA5 PMC4818113__F6 Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways NHS FES RHD PMC4938759__F1 Mammalian target of rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction MMP9 DEPTOR MLST8 PMC12106265__F3 ER stress in DILI ATF4 TRAF2 XBP1 PMC7765045__F1 Main pharmacogenetic biomarkers associated with conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment RFC1 DHFR HEL-S-70p NAT2 ABCG2 TPMT DHODH SLC19A1 PMC9547461__F7 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy HMGB1 GZMA IL1B GSDMB GSDMD DFNA5 PMC7020065__F5 During pregnancy recognition (PR) in cattle conceptus produced IFNT increased expression of type I IFN-stimulated genes (ISGs) in the uterine endometrium and increased prostaglandin (PG) production facilitates these effects PTGER2 PTGFR STAT2 IRF7 PTGS2 TRAF3 PTGER4 IRF3 IFNAR2 PTGER3 IFNAR1 PTGS1 TLR3 IFNG STAT1 TLR8 TLR7 PTGER1 OXTR TYK2 JAK1 IFNGR1 IFIH1 PMC7693003__F2 Role of FDFT1 in the biosynthesis of cholesterol, structure and roles of lipid rafts and regulation of FDFT1 by SREBP2 FDFT1 HMGCR PMC3108467__F4 IFN signaling pathway coded with identified proteins on day 7 postinfection GBP1 IRF9 BST2 PIAS1 PAICS TYMP IFI35 IRF-1 IFNG BAX PMC4274748__F4 Inactivating gene fusions of NF1 in lung cancer NF1 NLK MYO15A DRG2 PSMD11 PMC5381110__F6 Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues HEL-S-182mP SHMT1 GLDC PHGDH GCSH PMC7693003__F1 Biosynthesis of cholesterol and its derivatives FDFT1 ARHA RAC1 CDC42 PMC7219953__F1 Proposed mechanism of action underlying the fast and sustained antidepressant effects of ketamine GSK3B MTOR BDNF PMC2834833__F3 GSK3: a multifaceted kinase in Wnt signaling TSC2 LRP5 LRP6 PMC8535772__F3 Glutathione in Mediating Abscisic Acid Signaling and Its Regulation of Seed Dormancy and Drought Tolerance SNRK ABI2 MOCOS PMC6064680__F1 Model cell illustrating the Gq-mER signaling pathway in hypothalamic neurons POMC CAV3 NPY PMC11749302__F3 Selected results of natural product-based nanomedicines against liver disease HEL70 UBR5 GAL MPL PMC8607235__F4 SOCS proteins and their roles in the development of glioblastoma STAT1 EGF SOCS3 GSK3B TRIM24 PHLPP1 STAT3 PMC7498629__F2 Role of FoxO signaling in activating ubiquitin-proteolysis and autophagy-lysosomal pathway when skeletal muscle is immobilized MFN2 ULK1 IGF1 MUL1 MTOR SIRT1 FIS1 PMC9464948__F6 Luteolin induces pyroptosis in HT-29 cells by activating the Caspase1/Gasdermin D signalling pathway NLRP3 IL1B GSDMD PMC11702054__F2 TRIB2 in the physiological proliferation of granulosa cells, myoblasts, naive T cells, and thymocytes, and pathological proliferation of VSMCs EGR1 RUNX3 TRIB2 MTOR PMC11702054__F3 TRIB2 in the lung cancer cell, liver cancer cell, and leukemia cell proliferation GPX4 HOXA9 EBP TRIM21 MEIS1 TRIB2 TFRC SMURF1 RFWD2 HMGA2 CCND1 PBX3 HEL-S-133P TCF4 STAT3 BAX PMC8607235__F5 SOCS proteins and their roles in the development of glioblastoma EGF SOCS3 GAB2 OSM PMC2656900__F1 Working model for Eph receptor function in tumor promotion and tumor suppression ERBB2 EGFR ARHA PMC11702054__F5 TRIB2 in melanoma cell, colorectal cancer cell, ovarian cancer cell, and osteosarcoma cell proliferation TRIB2 TUG1 PMC4919052__F6 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq IL10 IL13 NFE2L2 MYC IFNB1 IL5 IFNG LEP AHR HNF4A PPARGC1A IL17A IRF-1 IL1B IRF2 TF STAT3 PMC4919052__F7 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq HNF4A PPARGC1A SREBF2 NR1C2 XBP1 NR1C1 PPARGC1B PMC4064697__F2 Schematic summary of the photoneuroendocrine control of food intake and body weight RARA TSHB CRABP2 TSHR PMC4686085__F4 Axon guidance pathway involving neuropilin 1 TH RAD1 SEMA7A SEMA3A FES ARHA ROBO2 RHOD ROBO3 FYN CXCR4 ROBO1 DCC NEK1 CDC42 PMC10136307__F4 Proposed ER-related mechanisms in the induction of autophagy and UPR in B cells TSC2 ULK1 TSC1 ATG12 ATF4 EIF2A TRIB3 AMBRA1 BCL2 UVRAG XBP1 DKFZp686F0183 PMC8469138__F3A Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis CYBA TPM1 RTP4 TTN OASL ITK CXCL16 TCAP CD2 CD84 TNNT3 CRTAM CD3G CD3E CD3D IRF9 ACTN2 CD44 CD96 CTLA4 SH2D2A STAT4 LCK HEL-S-273 SIT1 HRC CD226 PYGL PMC10136307__F2 Inhibition and induction of autophagy ULK1 ATG12 ATG101 UVRAG ATG10 DKFZp686F0183 PMC3675677__F1 Insulin-like growth factor type I (IGF-1R) signaling axis TSC2 TSC1 IGF1R PTEN GRB10 MTOR IRS1 RHEB PMC4407080__F1 Image of the MAPK signaling pathway painted by KPP according to the imported list of genes differentially expressed in the prostatic carcinoma as compared to normal prostate CD14 MAX GRB2 MOK EED PMC7487981__F1 Local area (subpathway) of retinol metabolism pathway is highly correlated with ALDH1A1 LRAT PNPLA4 DHRS4 UGT2B7 PMC3774847__F1 Schematic model of GMIP and Slp1/JFC1 regulation of vesicular dynamics and exocytosis in neutrophils RAB27A ARHA PMC7472693__F3 Coordinated regulation of the host NFKB pathway by L UBE2V2 HEL-S-71 SHARPIN TRAF6 MAP3K7IP1 PMC7025433__F1 Methionine metabolic pathway HEL-S-61p HEL-S-182mP MTR PMC10814159__F3 MDM2 and CDK4 pathway regulation MDM2 CDK4 CDKN2A PMC3386543__F7 Schematic of C/EBP A/B functions in GCs HEL-S-61p EGF RUNX2 NRP1 CYP11A1 STAR PMC10814159__F5 Activation of the Hh/GLI signaling pathway SUFU GSK3B CCND1 BCL2 SMO PMC4557273__F5 Sperm navigation along helical paths in 3D chemoattractant landscapes GC PMC9482985__F2 Transcriptional regulation of oil biosynthesis in seed plants: Current understanding, applications, and perspectives DGAT1 ENO1 MED15 PMC5681735__F1 Kynurenine pathway (KP) IDO1 HEL-S-90n IDO2 PMC6041131__F5 Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors DKK3 SFRP1 FFAR2 SOCS1 PMC5040710__F8 Illustration of role of differentially regulated proteins involved in different pathways in rice for sustaining during drought stress GLO1 CS HEL-S-162eP PMC9679345__F2 Gap Junction–Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells NOG MEI1 MOG MSC CD34 MAL PMC7176421__F6 Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement MTOR BDNF PMC9284435__F2 Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer FANCD2 SLC7A11 ATF4 TGFBI PMC150458__F3 Known Wnt signaling pathways HEL-S-11 APC ARHA PMC5862315__F4 HFD activates genes involved in inflammation and tumorigenesis ADAM8 ACKR3 BCL2L1 HMOX1 FKBP1A MMP3 MMP7 PLAT PTPN1 opn SRC LEPR HCAR2 MMP28 MED30 KRT1 ACKR2 FZD10 GATA3 WNT7B MMP10 MED4 KRT16 ADCY1 MMP9 MMP20 NTS HEL110 DUOXA1 S100A9 ADCY8 WNT10B WNT3 LEP S100A8 WNT10A SELP GJB6 TGFB1 STAT3 PMC6040091__F4 WNT/Beta-catenin signal transduction pathway APC LRP5 LRP6 PMC3978512__F3 Canonical WNT/Beta-catenin signaling genes marked in green are hypermethylated in parous women (suggesting down-regulation of the gene in parous women) PIN1 HEL-S-28 APC CD44 DKK1 MAP3K7IP1 WIF1 HDAC1 NLK MMP7 MDM2 SRC SFRP1 TCF4 PMC4087737__F1 A: The heme biosynthetic pathway FES ACD PMC4905365__F1 Targeting the lncRNA-dependent noncanonical Hedgehog pathway by LNA in combination with classical Hedgehog pathway inhibitors CCL21 SHH SMO RHO CIT POLI PMC6402450__EV2 Metabolic Reprogramming in Colon Cancer TIGAR PRM2 PAICS ACLY HEL-S-133P FASN PMC7915605__F6 Summary of steroidogenic pathways in primary trophoblast cells isolated from human term placenta HSD11B2 HSD3B1 HSD11B1 CYP11A1 HSD17B1 HSD17B3 CYP17A1 CYP21A2 PMC4128856__F7 Targeting c-Met in melanoma TSC2 HGF APC GATA6 MTOR RHEB PMC6014489__F1 The Wnt signaling pathway BAMBI GPC4 SOST WNT1 MYC SOX1 SMAD4 DKK1 CCND3 NKD2 PRKCA AXIN2 JUN DAAM2 FOSL1 RUVBL1 NFATC1 LRP6 SKP1 ARHA RBX1 WIF1 WNT10B DVL1 NLK CACYBP NR1C2 FRAT1 APC2 PMC3792350__F1 Overview of peroxisome biogenesis: converging de novo and growth and division models PEX19 PEX6 GET3 PEX3 PMC3808934__F1 RLR-mediated pathways of type I interferon and inflammatory responses TBK1 IRF7 TRAF3 TRAF6 IRF3 TRIM27 TRIM25 FADD PMC3808934__F2 Interplay of TLR and RLR signaling TBK1 TLR8 TLR7 TLR4 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC8371477__F2 Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease ERBB4 FOXN4 ERBB2 WWTR1 HAS2 BMP4 PMC7322959__F3 Differentially expressed genes in SPCs of GATA2 deficiency UROS DERA HEL-S-11 NCAPG RHAG LMNA YWHAG ERAF PMC11002443__F6 Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells MC1R MSRA PMC4037312__F3 PI3K/AKT/PTEN signaling, which modulate NOXs-derived ROS TSC2 TSC1 PTEN MTOR PMC3760732__F8 Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways HGF PTEN HES1 PMC7343183__F8 JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184 FOS JUN PRX YKT6 PMC9042933__F1 NRF2 Expression Under Different Conditions KEAP1 RBX1 CDKN2A NQO1 PMC4531138__F2 miRNAs control inflammatory response in ECs CXCL1 BTRC IRAK1 SMAD2 TGFBR1 TRAF6 CCL2 NR1C1 CXCR4 KLF4 KLF2 THBS1 CXCL12 RGS16 SIRT1 PMC5198544__F3 Tissue injected with B. asper venom IL1A TLR4 IL1B PMC11639970__F1 WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations APC GRB2 RHO MTOR JUN PMC8002238__F1 Cyclophosphamide metabolic pathway (adapted from Jonge et al., 2005 ) CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC3091413__F7 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways PLSCR1 CCNA2 MAPK8 TDG GSK3B RALBP1 FBXW7 FGFR2 CCNE1 SMARCA4 TBP CASP9 MAPK1 RAD51 MVP HSPA4 NOTCH2 MAP3K1 CDKN1B VEGFA BRCA1 CDKN1C CKS1B HEY2 CDK2 VTN CDK9 TGFB1 ITCH NUMB HIPK2 HEL2 JAG2 CCNH PTEN CASP2 GPS2 CHD3 NOTCH3 BAG1 CDK7 UBC UBE2I DLK2 RBL2 RBL1 MYBL2 FKBP5 HDAC1 IKBKB CASP3 CREBBP EP300 STUB1 PSEN1 NRP1 TRAF2 VEGFB SKP2 PMC3091413__F5 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Asian population NUMB CCNA2 GSK3B MYC JAG2 PTEN RB1 COL1A1 NOTCH3 FBXW7 UBC MCC MNAT1 FYN SMARCA4 TBP MSH6 MDM2 NOTCH1 PRKDC RBL2 RBL1 NOTCH2 MAML1 NCOA6 CHEK1 HDAC1 BRCA1 CBL RFC1 CREBBP HEY2 EP300 IGF1 PSEN1 CDK2 RAF1 CDK9 PXN PCNA SKP2 PMC3091413__F6 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways NUMB CCNA2 PTEN RB1 NOTCH3 WRN FBXW7 TP53BP1 UBC ERBB4 SMARCA4 ATM MDM2 NOTCH1 CCND1 RAD51 MSH2 PRKDC CASP8 NOTCH2 RPA1 CHEK1 BRCA1 RFC1 CREBBP EP300 CDKN1A CDK2 XPA FANCA ATR PCNA SKP2 PMC3091413__F4 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Caucasian population CCNA2 MAPK8 GSK3B MYC RB1 FBXW7 DLG4 SMARCA4 MAST2 E4F1 MSH6 MDM2 NOTCH1 ERCC5 MSH2 NOTCH2 BARD1 HEY2 IGF1 CDK2 HEL113 XPA ATR PCNA CASP4 IKBKE NUMB CHUK BLM PTEN CHD3 NOTCH3 WRN CHEK2 ATM UBE2I PRKDC RBL2 RBL1 MAML1 RPA1 CSTF1 CD44 HDAC1 CASP3 RFC1 GRIK1 RAF1 TRAF2 SKP2 PMC5620326__F4 Roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis NOX4 RAC1 STAT3 PMC8136131__F10 Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway PIK3R1 COL3A1 AGTR1 EGFR EFNB2 TBX3 MMP11 TGFBR2 FGFR4 WT1 WFS1 UCP2 TLR4 GDF15 SRPX ROR2 APOE EGFL6 NBEAL2 CLIP3 SDC1 AEBP1 TBX2 PF4 DPYSL3 IGFBP7 MAP2K5 ADRB2 FGF18 ID1 GNA11 GPX3 TWIST1 PDGFRL PPARG PMC5158012__F3 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target TREM1 MPO SYK MYD88 PMC5158012__F4 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target SYK LAT PMC5099115__F3 IGF-1R Signaling IGF1R IGF1 PTEN PMC4906927__F2 Schematic of the RBPJ structure and domains demonstrating the domain organization of RBPJ, NICD and MAM RBPJ BTD PMC5580472__F1 Extrinsic and intrinsic apoptotic pathways XK APAF1 TRAF2 FADD CCS PMC3405333__F9 Pathway component for cell cycle G2/M DNA damage checkpoint regulation CD2 ARC BRCA1 PMC5283822__F2 Ubiquitin signaling during lesion recognition in the GG-NER pathway CUL4B XPC RNF111 DDB2 RBX1 DDB1 USP24 OTUD4 USP51 UFD1L CUL4A PMC5283822__F3 Ubiquitylation events during TC-NER RBP1 INO80 RBX1 DDB1 UFD1L CUL4A NEDD4 UVSSA PMC5329931__F2 Effects of TAMs on tumor progression S100A8 CCL18 PMC8275893__F2 TCF7L2 in Type 2 Diabetes APC GSK3B LRP5 CD44 LRP6 RYK PMC8275893__F3 TCF7L2 in Type 2 Diabetes APC GSK3B LRP5 LRP6 PMC4736120__F1 Approaches for xylose-based fatty alcohol production and improvement XDH CIT MAL PMC8254604__F2 Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics AHR KEAP1 EBP ATF1 TRAF6 IL23R TRAF2 STAT3 PMC2947794__F1 Examination of Association to Autism of Common Genetic Variation in Genes Related to Dopamine TH DDC DBH MAOA PAH PMC9231384__F5 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research FZD3 APC CCND1 PMC7067536__F7 Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications HPS6 ZNHIT2 USF2 MARF1 LHPP OSBP2 RAB20 TPO DDIT3 HELZ DHRS3 CSF1 FOXE1 KNL1 PMC9231384__F6 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research NFKBIA CAPRIN1 PMC3293935__F4 Known apoptotic targets of P53 CASP3 PERP CASP9 PHLDA3 PTEN DDIT4 PMC4370592__F6 Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model BAD CDKN1A CASP9 PTEN NKX3-1 PMC6945997__F3 Recognition of Candida species is mediated by Toll-like receptors (TLRs), C-type lectin receptors (CLRs) and nucleotide-binding oligomerization domain (NOD) receptors TH NLRP3 CARD9 BCL10 RAF1 IL1B NOD2 PMC11714729__F3 Hedgehog signaling pathway SUFU SHH SMO PMC11592846__F4 Lactic acid in macrophages during inflammation as a signaling molecule SLC5A8 MMP9 VEGFA SLC5A12 ARG1 STAT3 PMC5736922__F1 Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications GPRC6A NOX4 TRPM8 PMC8817698__F3 MAVS Immune Recognition Pathway in Viral Infection and Sepsis TBK1 IRF7 IRF3 MAVS PMC8817698__F4 MAVS Immune Recognition Pathway in Viral Infection and Sepsis OTUD1 NLRX1 MAVS PMC9701731__F1 Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination NF1 PDGFRA OLIG1 SOX10 BDNF OLIG2 PMC9617479__F1 Metabolic features of innate lymphoid cells CS ACAT1 ACLY GLS PMC4530265__F8 Proposed schematic showing targets of edible bird's nest (EBN) action in the insulin signaling pathway IKBKB PRKCZ GCK MTOR INSR PMC9617479__F2 Metabolic features of innate lymphoid cells ACAT1 MYC ACLY MTOR PMC4408865__F1 An example of positive and negative regulation of the Ifn-signalling pathway STAT2 IRF8 IRF9 TRIM21 TRAF6 TRIM8 IRF3 MYD88 TLR3 STAT1 TLR4 TYK2 JAK1 SOCS1 MAL PMC9617479__F3 Metabolic features of innate lymphoid cells DGAT1 MTOR ARG1 PMC10740511__F4 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer NUMB MAML3 CTBP1 JAG2 MFNG RBPJL DLL3 HES1 HES5 DTX3L MAML2 NOTCH1 DVL2 SNW1 HDAC2 NCOR2 NOTCH2 NOTCH4 KAT2B PSEN2 DTX1 DTX2 DTX3 DTX4 DVL3 CREBBP EP300 KAT2A PSEN1 PMC10740511__F5 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer CTBP2 NUMB JAG2 MFNG RBPJL NOTCH3 HES5 DTX3L MAML2 NOTCH1 DVL2 SNW1 HDAC2 NCOR2 NOTCH2 NOTCH4 KAT2B PSEN2 DBX1 DTX2 DTX3 DTX4 DVL3 DVL1 CREBBP EP300 KAT2A PSEN1 PMC12135473__F2 Dual roles of AIF in cell death and in vital mitochondrial functions CHCHD4 NDUFS5 PMC7761568__F2 Influence network of TCR signalling SMAD2 PTEN CTLA4 TIGIT LAG3 FOXP3 IFNG MAF IL27 STAT4 GRB2 IL2 NFIL3 YY1 CD80 CD226 LAT ICOS STAT3 PMC9583131__F2 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice CD14 IRF3 IL1B TLR3 PMC6629960__F1 Air pollution and ultraviolet radiation (UVR) on the skin AHR CYP1B1 CYP1A1 PAH PMC9583131__F3 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice IL16 AHR IL1B PMC5429641__F7 Neuroprotective action of MMP-9 in preventing ABeta-mediated impairment of the insulin survival pathway GSK3B BDNF IRS1 PMC5607574__F1 Schematic of Hh signal transduction in Drosophila and vertebrates KIF7 SUFU SMO GLA PMC8081860__F3 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? MPO LAMP3 RAB27A LYN MYD88 TNF TIRAP PMC4564046__F1 Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution MAF GCLM KEAP1 GCLC NQO1 PMC8081860__F4 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? CD6 LCK ZAP70 USP9X MYD88 MTOR LAT CD3E PMC7793839__F1 Toll-like receptor 4 (TLR4) signaling pathway TBK1 TLR4 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 IL1B PMC3274489__F1 Overview of the mevalonate pathway C6 PMC3384380__F2 Schematic depiction of NFKB signaling pathway highlighting FOXP1 target genes EGF NGF HEL-S-71 GSK3B PLCG2 HDAC1 CARD11 LTA NFKB2 LCK ZAP70 HDAC2 CD40 TRAF2 LTBR TIRAP PMC6731300__F9 The proposed model GPX1 PHLDA3 SRXN1 PMC3374082__F7 Schematic representation of the data IL6 NOTCH3 NR1C1 APOE PMC5301050__F1 Cancer Therapies in HIV Cure Research CD80 IFNG PMC4146420__F1 Prostaglandin synthesis pathway COX1 ALOX15 ALOX12 ALOX5 PMC5137279__F4 Pictorial representation of altered GABA receptor signaling due to PCP-SI treatment UBQLN1 ABAT SLC32A1 CP GABARAP GPHN ALDH9A1 PMC7198750__F2 Depiction of the cGAS-STING pathway ULK1 ATM TREX1 SLC19A1 PMC11768203__F2 Virulence factors of Fusobacterium nucleatum CXCL1 TLR4 BIRC3 TIGIT MYD88 TNF PMC8122623__F2 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia SFRP4 MAML1 SOST MSC LRP5 LRP6 ROR2 PMC8122623__F3 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia MSC GRB2 CNP SKI PMC4783232__F1 MicroRNA deregulation in cancer cells and the tumor microenvironment AGO2 DGCR8 EGFR MYC DROSHA KDM6B PMC4959859__F8 Schematic mechanism of L5 on STRA6 cascade suppression and kidney injury HEL111 RBP4 PMC7959398__F7 Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection DAO CD48 CTLA4 TNF CBL ITK FYN BCL10 LCK GRB2 CDK4 LAT ICOS CD3E PMC4587406__F1 Dysregulation of dNTPs in cancer pathogenesis and its targeted therapy CDC2 ATR PMC11818720__F5 Carbohydrate metabolic pathway diagram PKP3 PCK2 MME PMC4287999__F4 Mechanism of T-helper-17 (Th17) cell-mediated lymphangiogenesis VEGFC IL18 IL1B PMC5843405__F3 SUMOylation in representative cancer pathways SMAD2 TGFBR1 SMAD4 TNF PMC9288288__F9 Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases TH INA APP tal-1 STAR PMC7325056__F10 Intestinal microecological mechanism of diarrhea caused by Folium sennae extracts ASMT AOX1 DDC AANAT PMC10505224__F0 By hindering hnRNPA2B1 from binding to the E3 ubiquitin ligase TRIM21, whose mediated ubiquitin-dependent degradation was thereby inhibited, CRNDE protected the stability of hnRNPA2B1’s high protein expression in CRC TRIM21 HNRNPA2B1 PMC7286818__F2 Emerging roles of WBP2 oncogene in human cancers WNT3A TNIK APC HOMER3 GSK3B AXIN1 ENO1 LATS1 AXIN2 WBP2 JUN LATS2 PMC10540449__F3 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications ACVR1 BMPR1A APC GSK3B IBSP KLF4 SMAD4 DSPP DKK1 SMAD1 DKFZp781O1323 SMAD9 PMC10540449__F4 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications BMPR1A APC SMAD6 SMAD4 SHH HEL113 UNG SMAD1 MKI67 DKFZp781O1323 SMAD9 PMC10540449__F1 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications ATF2 SMAD6 SMAD4 MAP3K7IP1 SMAD1 DKFZp781O1323 SMAD9 PMC6547588__F1 Spatial regulation of non-amyloidogenic and amyloidogenic processing of APP BACE1 VAMP2 VAMP3 PSEN2 PSEN1 BIN1 GGA1 APP ADAM10 PICALM ARF6 CD2AP PMC7011106__F2 Gene-gene interaction among genes associated with atypical antipsychotic-induced lipid disturbances LEP POMC NPY ADRA2A AgRP MC4R DRD2 BDNF CNR1 PMC5310915__F12 Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken UBC PLTP UCP1 HEL-S-28 LPL PMC8786307__F2 Inflammasome-independent signalling by NLR proteins in the intestinal epithelium during CRC NAIP NLRP12 NLRX1 MTOR AIM2 NLRC3 STAT3 PMC9482771__F6 Target genes implicate in inflammation process potentially altered by miR-378 BRAF LEFTY1 NODAL FLNA LAMTOR3 MYC TGFBR2 ULK2 MAP2K6 TFDP1 SHC3 CCNG2 PDPK1 CACNA1C NCK1 NF1 BMPR2 ATM BMP8A FOXG1 FGF19 RPS6 BMP8B ABL2 GDF6 ATG12 E2F5 NRG1 CAB39 CBL CACNG8 GNG12 PRMT1 GIG8 HOMER2 IGF1 SMURF2 STK4 HSPA1A DUSP8 DUSP3 RPS6KA2 RPS6KA6 PMC6547588__F5 Involvement of LOAD risk factors at the BBB RAC1 PICALM ABCB1 CD2AP APOE PMC11583660__F1 Urinary estrogen metabolite before and after values CYP1B1 CYP3A4 CYP1A1 PMC4007997__F4 Molecular pathway analysis of regulated membrane protein changes in RLSCs as they undergo hepatocytic differentiation JUP TES FBLIM1 ENO1 EZR HEL113 LGALS4 RPSA LGALS2 CDH17 PMC7198750__F5 Cell interactions in TME engaging the cGAS-STING pathway CGAS HEL-S-92n PMC3524689__F2 Proposed model of OGP(10-14) differentiation signalling TPO ARHA TGFB1 MPL PMC4007997__F5 Upstream regulator analysis of membrane protein changes in differently regulated proteins involved in cell-to-cell signaling and interaction CORO1C ITGB4 HEL-S-108 JUP H6PD ACTN1 HNRNPC SNAI2 MAOA HEL113 PTGS1 PMC5503689__F2 Inflammasome complexes: emerging mechanisms and effector functions CGAS TLR4 AIM2 IL1B PMC7198750__F3 Interaction of the cGAS-STING pathway with other DNA-sensing pathways and its role in cell survival TBK1 NLRP3 CGAS APAF1 RELA TREX1 IRF3 MYD88 AIM2 TFAM SOCS1 PMC5807683__F5 Pharmacological targeting of KLFs in vascular inflammation KLF5 KLF4 KLF2 MTOR NR1C1 SIRT1 PMC6177618__F1 Calcium‐sensing receptor signalling and trafficking FH PIR PTH PMC1236696__F1 IKK/NFKB signaling pathways VCAM1 RELB IRF3 IL1B LTBR RXRA PMC6814074__F2 Non-genomic mechanisms of thyroid hormones action in the brain TH MAPK1 MTOR STAT3 PMC2832144__F11 Proposed model for the signal transduction pathways involved in TGFB1-mediated fibroblast-myofibroblast differentiation EGF SMAD2 EGFR CD44 SMAD4 HAS2 PMC8080639__F1 General unfolded protein response pathway during ER stress ATF4 EIF2A TRAF2 XBP1 PMC4167033__F7 IGF but not the EGF signaling pathway is regulated by the NEDD4-PTEN circuitry EGF IGF1R IGF1 EGFR PTEN IRS1 NEDD4 PMC6028759__F1 Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus APC SFRP5 PMC7844295__F2 Biosynthetic pathways of glycerophospholipids in rat hippocampus PLPP1 LPCAT3 HEL-S-25 AGK GPX1 LTB LPA ACSL6 LTA PC AGPAT3 ACSS1 EPHX2 LPCAT4 ACSF2 PMC7844295__F3 Glutathione metabolism GPX4 LOC51064 GSTM5 GSTM1 GPX1 CNDP2 MGST3 NNT HEL-S-22 HEL-S-26 GSTT2 HEL-S-64p GSTA3 AGL PMC9138696__F1 Stressing the Regulatory Role of Long Non-Coding RNA in the Cellular Stress Response during Cancer Progression and Therapy EGR1 ATM RPA1 MYC PMC7688371__F1 Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism TH TPH2 PMC3816993__F2 Combined miRNAs and transcription factor regulation of inflammation in wound healing IL10 TLR9 FOS IRAK1 TGFBR1 ALB CREB1 TRAF6 IL6 CCL2 TNF DDIT3 NTF3 CREBBP TLR7 TLR4 NFKB1 SP1 REL JUN IRF-1 SP3 PMC7517787__F8 Mechanism model of exogenous MT in delaying the post-harvest decay of wax apples STX2 PMC7738628__F5 Selected P5 and/or P10 enriched pathways PIK3R1 PIG59 GSK3B MYD88 MTOR HMOX1 MAP2K6 PRKCA BTK ACVR2B GRIN1 INPP5D ATF4 CALB1 GABRA2 PTPN6 JUN EGR1 HSPB2 FOS CD200 GABRB2 CD79B DDIT3 GABRA4 CNTF PIK3C2B HEL-S-102 HLA-A NTF3 NFATC2 DUSP10 TNFRSF1A GABRB1 PLA2G5 GRIN2B CD40 MAP3K8 SYK BDNF PYCARD PMC4039984__F1 Chromatin Landscape and Transcription Factors in T-Cell Programming RUNX3 RUNX1 STAT4 IRF4 GATA3 STAT3 FOXP3 BATF PMC5220678__F2 Loss of Axin2 can cause MVD by shifting TGFB/SMAD3 pathway toward WNT/Beta-catenin and BMP signaling BMPR2 BMP2 APC SMAD6 TGFBR2 SMAD4 TGFBR3 SMAD1 TGFB1 DKFZp781O1323 BMP4 PMC11889592__F3 miR-34 family has suppressor effects on cancer invasion, proliferation, and metastasis by regulating molecular pathway HMGB1 PDGFRA EGFR PTEN CDK6 NOTCH1 CCND1 GDNF BCL2 CDK4 CDC2 SIRT1 CCNE2 BAX PMC7738628__F6 “Synaptogenesis signaling” seIPA-path schematic representation in HI exposed P5 (upper panel) and P10 brains (lower panel) CDH8 RASD1 CDH11 SYN2 CDH12 GRIA3 STXBP5 NRXN3 MTOR EIF4EBP1 GRIA2 SYT1 EPHB3 GRIN1 AP2M1 ATF4 UNC13A GRIN2B EFNB3 GRM8 EPHA2 NTRK2 CAMK2A PMC3401681__F3 Mesenchymal stem cells (MSCs) may have both growth inhibitory and stimulatory effects on tumours MSC IL6 STAT3 PMC4614032__F1 mTORC1 signaling pathway TSC2 TSC1 RHEB PMC7401609__F3 Fat metabolism in the subcutaneous fat of yaks under long-term energy stress (ES) ACOT8 ACAD9 IL6 TG ACSL6 LEP LIPE AQP7 ELOVL5 ELOVL7 FADS1 ACOX3 ACSL3 PNPLA2 PMC10869786__F7 The mechanism by which FXR promotes NSCLC metastasis IL6ST STAT3 PMC7401609__F4 Energy balance in yaks under ES by regulating fat metabolism LEP ACOT8 SLC2A4 PFKFB4 ACAD9 MTOR ACOX3 PMC8656796__F5 Therapeutic Efficacy of Variable Biological Effectiveness of Proton Therapy in U-CH2 and MUG-Chor1 Human Chordoma Cell Death TNFRSF4 TRAF5 TRAF3 TNLG2B TRAF2 JUN PMC8831562__F3 USPs and TGFB signalling USP4 USP26 USP15 CYLD SMAD2 SMURF2 GSK3B SMAD4 PMC10561274__F2 Inflammation associated signaling activated by fractalkine CX3CR1 KEAP1 CX3CL1 TNF PMC7719135__F2 Mechanism how MCPIP1 and cytokines mutually regulated in macrophages CCR2 TANK TLR4 TRAF6 MYD88 XPO5 PMC8831562__F2 USPs and NFKB signalling USP15 USP19 TRADD CYLD TRAF6 TNF TRAF2 TAB3 PMC3937154__F5 IPA graphic representation of the network “Cell death and survival, DNA replication, recombination, and repair, cellular response to therapeutics”. Nodes represent genes and lines show the relationship between genes NUPR1 SNAI2 PTEN PMS1 MOCOS CCNE1 ISG15 PERP opn NRAP BTG2 PRKDC FDXR NLRC4 IGF2 GADD45A IRF3 LRRC17 DDB2 RPS27L CASP10 BRCA1 IKBKB CASP3 BRCA2 BBC3 RELA TNFSF10 TP73 TYMS YY1 TRIM24 TNFRSF10B TNFRSF10A DCAF6 PCNA PMC2770888__F2 Targeting EGFR resistance networks in Head and Neck Cancer BAD GRB2 CCND1 SRC PTEN MTOR STAT3 PMC7870996__F1 Dual regulatory effects of TRAP1 on the mitochondrial apoptotic pathway ATF4 EIF2A TNF CPD PMC7396304__F1 Quantitative Measurement of Redox State in Human Brain by 31P MRS at 7T with Spectral Simplification and Inclusion of Multiple Nucleotide Sugar Components in Data Analysis MDH2 HEL-S-162eP PMC7453310__F3 Alternative splicing regulation of the oncogenic MYC and RAS-MAPK pathways MAX EGFR MYC SRPK1 RAC1 EIF4E PMC11021402__F5 Fe and S binding by ISCU2 at consecutive stages of de novo [2Fe-2S] cluster biosynthesis FDX2 FXN PMC6918076__F6 Schematic illustration of AHR activation modulating HIV-1 transcription AHR CDK9 PMC7765317__F2 Nuclear factor-E2-related factor-2 (NRF2) pathway exerts antifibrotic effects GCLC NQO1 PMC7765317__F3 Reactive oxygen species (ROS) trigger fibrosis via several inflammatory pathways NLRP3 TLR4 TXNIP MYD88 IL1B PMC4710564__F7 Specialized pro-resolving mediators (SPMs) inhibit human B-cell IgE production JAK3 JAK1 PMC7340996__F2 Structure of the filaments containing Septins 7/9b/11 and Jun N-terminal kinase signaling pathway SEPTIN7 SEPT9 PMC12210160__F1 Anti-hepatitis B virus hepatic innate immunity in hepatocytes IL10 MYD88 EZH2 TNF IL1B TLR3 MAVS MAL PMC5514694__F9 Coordinating reactions in the intestine elicited by LGG in response to S CCR6 CCL20 LPL IFNG STAT3 PMC2820234__F3 Suggested signaling of the early stages of 1,25D-induced monocytic differentiation CD14 EGR1 NR1i1 EBP CDK5 PMC8314387__F2 Signaling Pathways Involved in Diabetic Renal Fibrosis SMAD2 SMAD4 PMC8314387__F3 Signaling Pathways Involved in Diabetic Renal Fibrosis SMAD2 PMC11482726__F10 Working model for NONO positively regulating IRF3-mediated IFNB signaling pathway by detection of PRRSV N TBK1 NONO IRF3 MAVS PMC5628354__F5 Proposed deglycosylated metabolic pathway of Panax ginseng saponins by rat intestinal microflora F2 RB1 ARAF PMC7093422__F6 Detailed information of sub-pathway (AGE-RAGE signaling pathway in diabetic complications) in the KEGG VEGFD TGFBR1 SMAD4 COL1A1 STAT1 PRKCA PIM1 MMP2 F3 CCND1 PLCD3 JUN SELE BAX IL1A NFATC1 RAC1 IL6 TNF HRAS CYBB FOXO1 CASP3 AGER VCAM1 NFKB1 PIK3CA BCL2 TGFB1 AKT3 STAT3 PMC9143056__F2 Inflammation by Plant-Derived Nutraceuticals in Tendinitis COX2 IL13 STAT3 PMC5056326__F1 Epidermal growth factor receptor signaling along with co-activated other receptor tyrosine kinases BRAF EGFR PIK3CA PTEN MTOR PMC5056326__F2 Possible resistance pathways to epidermal growth factor receptor blockade; gain of mutations in KRAS, BRAF, and PIK3CA and upregulation of other receptor tyrosine kinases PI3 BRAF EGFR PTEN MTOR PMC3518557__F1 Targets and structure of compstatin HEL-S-62p C1S CP PMC8666287__F6 Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling NOTCH1 PMC3696549__F10 Reciprocal regulation by TLR4 and TGFB in tumor-initiating stem-like cells TLR4 IGF2BP3 YAP1 TGFBR1 TGFBR2 MTOR PMC3552454__F4 Advances in graft-versus-host disease biology and therapy STAT1 APC HEL-S-92n MYD88 TNF NOD2 PMC8460989__F8 Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages ISG15 OAS1 TLR3 MX2 PMC7313221__F4 Main mechanisms involved in the development of HCC TLR4 MYD88 CYP2E1 PMC4544723__F7 Proposed schematic showing targets of EBN action in the insulin signaling pathway IKBKB PIK3CA GCK MAPK1 INSR PMC8530523__F3 Epigenetic regulation of energy metabolism in obesity OGT SIRT6 SIRT1 PMC2631402__F4 The Legionella pneumophila replication vacuole: making a cozy niche inside host cells NOD1 BNIP3 NOD2 SDHA PMC4023801__F2 Proposed metabolic activation pathway of GS-6620 HINT1 CES2 CES1 PMC11613313__F2 Endometrial Receptivity Affected by Fibroids HOXA11 BMPR2 BMP2 SMAD4 HOXA10 SMAD1 ADM PMC6192166__F3 Proteomics and phosphoproteomics driven identification of the aberrant regulation of signalling pathways leading to poor patient survival PLCG1 VASP TLN1 RHO GIT2 SHC3 STAT1 PRKCA SRC HEL114 JUN ARHGEF7 CSK FOS HEL-S-28 MAPK10 DOCK1 HRAS CRK RAC3 MYLK2 PRKCB ZYX GRB2 TNS1 JAK1 RAF1 SOS1 SHC1 PXN AKT3 STAT3 VAV2 PMC5836465__F3 Unfolded protein response ATF4 EIF2A BCL2 TRAF2 BAX PMC3528779__F6 Global Effect of Inauhzin on Human p53-Responsive Transcriptome CASP3 TSC2 PERP ATM CDK2 MYC PTEN ATR RFWD2 AMT PMC12131027__F5 Schematic model illustrating potential pathways after PRRSV infection in PAMs with identified DEPs based on our study TBK1 MHC2TA RFX5 IRF9 TRAF3 CREB1 RIGI IRF3 CD74 TLR3 MX2 MX1 STAT1 ISG15 OAS2 ISG20 TYK2 JAK1 SCARB2 B2M SLA2 NFYB IFIT1 PMC9654795__F1 Ferroptosis: A New Development Trend in Periodontitis GPX4 LPCAT3 FACL4 SLC7A11 NF2 PTGS2 GLS2 SLC3A2 PMC10608450__F5 Protein–protein interactions between 341 members of antimicrobial peptides in Trachinotus ovatus PLA2G1B APP CALCB CXCL14 NCAN ADK PMC3925772__F7 Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module RICTOR SRC IL6 MTOR STAT3 PMC5275750__F1 Cancer Cell Metabolism and the Modulating Effects of Nitric Oxide PI3 VHL MTOR PMC6492140__F1 Global and specific regulation of translation initiation ELF2 ELF5 EIF4E EIF5 PMC5584588__F7 Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3’-end processing factors is a conserved DNA damage response in eukaryotes RBX1 PMC2071927__F2 TUNING IMMUNE TOLERANCE WITH VASOACTIVE INTESTINAL PEPTIDE: A NEW THERAPEUTIC APPROACH FOR IMMUNE DISORDERS STAT1 CD14 TLR4 TBP JUNB JAK1 IRF-1 VIP IFNG PMC8740192__F1 Myostatin on the Growth and Development of Skeletal Muscle MYF5 SMAD2 SMAD4 MTOR PMC8339209__F2 Recent Progresses in the Treatment of Osteoporosis RUNX2 APC GSK3B LRP5 LRP6 ROR2 SP1 JUN PMC8598918__F2 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? CXCR4 EGFR SPRY2 PMC8598918__F1 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? NF1 ERBB2 EGFR VILL PTEN PMC2360352__F1 Schematic depicting the central role of HER3 in mediating PI3K/Akt signalling downstream of the HER family BAD EGFR PTEN MTOR PMC4699279__F1 Gliadin peptides pass through the epithelial barrier paracellularly or transcellularly CXCR3 APC EGFR MYD88 PMC8203646__F8 Meta-analysis of gene signatures and key pathways indicates suppression of JNK pathway as a regulator of chemo-resistance in AML NLRP3 IL18 IL1B PMC7718059__F8 KEGG pathway enrichment of the S100 genes and their significantly related genes selected from the top 5 module analysis BAD CRK PMC11280316__F8 Suggested schematic illustration of the mechanism by which crocin could induce cell survival and exert anti-oxidative and anti-inflammatory effects in stressed cardiomyocytes TLR4 MMD KEAP1 F3 PTEN MYD88 MTOR NQO1 BAX PMC5581122__F7 Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling POMC AgRP MC4R NTS ARC PMC8235527__F1 Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System TSC2 TSC1 PTEN RHEB PMC5796908__F1 Activated endothelial cells modulate allogenic T lymphocyte activity TH IFNG PMC6983837__F10 RIG-I activation in the context of influenza infection IRF3 TRIM25 MAVS PMC9220936__F2 MicroRNAs in the Regulation of Solute Carrier Proteins Behind Xenobiotic and Nutrient Transport in Cells SLC7A11 SLC3A2 MTOR PMC9300056__F3 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum SHD RET MAX SEC31A BAGE SEC23A BAX PMC4621122__F8 Hypothesized model for E4-ORF1-induced constitutive Myc protein expression mediated by EGFR, InsR/IGF1R, and PI3K IGF1R EGFR MYC MTOR INSR PMC9300056__F2 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum AGO2 RPN2 BAG6 PMC6421647__F6 hBM-MSCs-Ex treatment alleviates liver fibrosis in both HSCs and liver fibrosis tissues through inhibition of Wnt/Beta-catenin signaling (PPARG, Wnt3a, Wnt10b, Beta-catenin) and the downregulation of downstream gene expression (WISP1, Cyclin D1) WNT3A CCND1 WNT10B PMC7461110__F1 Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer Therapy TIGAR ATM MDM2 GLS2 ATR BAX PMC8859258__F2 Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients’ Stratification COX2 COX1 APC MDM2 GRB2 PMC2971717__F1 Schema of the HER family signaling pathways HEL-S-11 EGFR GRB2 PMC3904369__F1A Charity begins at home: non-coding RNA contributes to DNA repair ATM DROSHA HDAC2 BRCA1 PMC3809843__F9 Gremlin regulation of LOXs in TM LOXL2 BMPR2 LOXL4 SMAD2 TGFBR1 TGFBR2 SMAD4 LOXL1 PMC9367540__F2 Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders TBK1 CGAS TLR4 TLR9 IRF3 TFAM PMC11955793__F6 hUCB-MNCs inhibit fibrosis process BAD SMAD2 CDH2 PMC12012570__F2 CIH modulates glial cells in the CNS through various mechanisms NLRP3 SENP1 MYD88 ROS1 PMC8743908__F2 Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease KMO SIRT1 SIRT3 PMC8859258__F4 Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients’ Stratification TRADD PDF TNF TRAF2 PMC11955793__F5 Anti-inflammatory and antioxidant effects of hUCB-MNCs IL10 KEAP1 IL13 IL2 IL6 TNF PMC5973613__F7 Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms IGF1R TXNIP FFAR1 PMC2515131__F2 Signal transduction events initiated by Kit and FcERI leading to specific mast cell responses, and the integration of these pathways for the synergistic enhancement of mast cell mediator release KIT GRB2 SHE LAT PMC3908275__F5 Interaction of MSCs and HSCs KIT CXCR4 MSC SHH SMO CDH2 HES1 PMC4392459__F1 The CoA-dependent butanol pathways used for the production of propane in E AHR HBD PMC9032991__F8 Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs PGGT1B FDPS CYP1A1 FNTA PDSS1 PMC7492613__F3 JAK-STAT modulating genes in PMN-MDSCs in the circulation of CRC patients ADIPOR1 LEP IRF9 APC STAT4 GFAP MYC GH1 BCL2L1 MTOR PMC8698579__F1 YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango CXCL5 IL8RB TEAD4 PTEN CTLA4 MYD88 CD19 TEAD2 PMC11414529__F2 Injury induced by histone methylation disorders in diabetic nephropathy affect the major effector cells of the kidney HIPK2 KLF10 NTRK3 DACH1 DKK1 CCL2 WT1 ADAM17 NOTCH1 KLF2 SFRP1 EZH2 CTNNBIP1 WDR82 EZH1 SOX6 PMC4389010__F1 The Th17 pathway and its involvement in psoriatic disease IL10 CXCL1 CXCL5 IFNE CXCL8 CXCL3 IL6 MMP3 PDC CCL20 CXCL6 IL-21 IL20 STAT3 PMC6478763__F1 Mechanisms supporting BRAF inhibitor resistance in melanoma PIK3R1 DUSP4 BRAF FOSL1 NRAS RYK HRAS SRC FZD7 CCND1 PIK3CA SOX10 JUN STAT3 AKT3 PMC8384742__F1 Gastrointestinal mucosal immunity and COVID-19 ACE2 TMPRSS2 IFNG FOXP3 PMC2268740__F1 Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster TH DDC TRH PMC3200079__F3 Homeostatic and leukemic expression of receptors, signaling proteins, and transcription factors along the B cell pathway PREB PAX5 IL7R JAK1 CD19 PMC6466196__F1 Schematic of IL-4 and IL-13 mediated signal transduction STAT1 TYK2 JAK3 JAK1 STAT3 PMC2890032__F2 Differential vulnerability of neurons in Huntington's disease: The role of cell type-specific features TH HEL70 BDNF PMC9316217__F9 Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells TNF IL1B PMC11062289__F5 ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency ENPP1 FGF23 NR1i1 SFRP1 MYH10 WIF1 FZD8 PMC5360281__F2 Visualization of selected miRNA targeting events on the insulin signaling pathway (from WikiPathways) MYO1C PTEN PFKM SHC3 XBP1 INSR PRKCA FLOT1 PTPN11 JUN PRKCI RAPGEF1 IRS4 NPPA STXBP4 FOS EHD1 STXBP1 RRAD PFKL SNAP25 TBC1D4 CRK IRS1 SNAP23 RHEB CBL FLOT2 SHC2 TSC2 GYS2 TSC1 VAMP2 PTPRE CSA2 SHC1 CBLC PMC11868719__F4 Signaling pathway of LPS-induced apoptosis TLR4 MYD88 BAX PMC6456539__F2 Activation of autophagy process by extracellular vesicles EGFR MTOR STAT3 PMC11868719__F1 Using the String database to analyze protein interactions PLK1 NPM1 SMYD2 RING1 USP11 SOX4 MAGEA2B NR1i1 BCR SAFB BCLAF1 HTT SREBF2 DVL2 HEL-S-44 SP1 PRKAB2 VRK1 SPOPL SNCA NCL BAK1 TP63 RNF2 PPIF TK1 PCGF2 PPP3R1 ZNF420 AIMP2 CEBPZ AXIN1 BCL2 PPP2CA SPOP HEL-S-283 CUL9 SUMO1 ZNF76 NUMB DKFZp781B1423 RCHY1 CEBPB CHEK2 CXXC1 TLR4 RYBP APP ETS2 NFYB NR0B2 HUWE1 MBL2 RNF4 HDAC1 BCL2L2 RFWD2 CREBBP EP300 HEL164 PEX26 TRIM24 TPT1 ACD PLEKHO1 PIN1 PHLDB2 TBCB IRAK4 TXN TP53BP1 SIAH1 PIAS2 MDM2 HEL-117 NOC2L UVRAG CISD2 RUVBL1 BRD7 STAP2 UHRF2 PIK3R3 RPS3 PYCARD SIRT1 PML BAD SFN TICAM2 NOX4 LY96 WRN UBC MED1 NCOR2 MAL BAX HMGB1 NUAK1 FOXO3A DUSP26 PARP1 MAGEB18 SPNS1 KMT2E MAGEC2 HEL-S-102 ZNF35 HINFP BBC3 PMAIP1 RFWD3 MT1A MCL1 SCML2 HEL-S-93 FADD TCF4 TIRAP BCAP31 PMC11868719__F2 Using the String database to analyze protein interactions SNAI1 CCNA2 KEAP1 GSKIP MYC DEAF1 FYN BCL10 HTT HEL-S-44 NOS2 SNCA PEBP4 APC LRP6 TNF TK1 HEL-S-68p TSC1 PRKCB CEBPZ STK4 SHARPIN AXIN1 PPP2CA CLTC PRUNE2 SUMO1 TBK1 PLCG1 OSGIN1 AMOT RNF31 PPP2R1A GIT2 NBR1 APP ZFPM1 FASN ANXA1 LRRK2 NR3C1 CDC37 SYT1 AURKA CARD11 NFKBIA CREBBP ERBB2 ZC3H12A PRKCZ GNB2 TXN CYLD ASXL1 SNW1 CALB1 SLU7 SRC TNIK PPL RBCK1 SETDB1 MCM7 STAP2 KRT18 FOXO1 CDK2 HEL113 ATR RPS3 TNFAIP3 DACT1 SIRT1 MAVS FKBP6 IKBKG CHUK TANK SQSTM1 EGFR RELB MTOR TTC3 UBC RARA RIPK1 MESD ATM GAL SP7 RNF7 FOXO3A GYS1 CARD9 CARD19 ZNF835 SLC41A3 AK3 NFKB1 S100A8 GMCL2 RELA BTBD1 CEP76 ENKD1 BICD1 PRPF18 TRAF2 ZNF587 SMAD1 GPKOW CAMK2A NCAPD3 APPL1 PMC7877795__F4 Origin of tumor- and metastasis-associated macrophages in mouse models of breast cancer EGF HGF CTLA4 CCL2 IL4 CXCL12 CSF1 CCL3 PMC7855621__F2 Centriole and cilium biogenesis FBF1 CCDC41 SCLT1 CEP89 CEP164 C2CD3 PMC8946735__F3 Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease GNG4 GABRB3 GABBR2 SLC12A5 GNG2 GABRE GNAS GRIA2 GNG3 KCNJ3 SLC17A6 GLS PMC8905719__F2 RAS pathway regulation in melanoma NF1 SOS2 FOS MYC MDM2 GRB2 PTPN11 SOS1 MTOR PMC7438927__F6 Canonical Pathway of ‘Actin Cytoskeleton Signaling’ in IPA with AA-specific/enhanced genes in EGF FLNA BAIAP2 APC ARHA ABI2 DOCK1 CRK GNG12 F2 GRB2 SRC HEL114 PXN TRIO PMC7438927__F7 Relationship between a network of DEGs and the canonical calcium signaling pathway CPA4 REN BMP10 HP ITLN2 XIRP2 ANKRD2 HAND1 SOSTDC1 CP PCDH10 PMC7438927__F8 Networks of an unreported AA-specific/enhanced DEG (CHRNE) CACNA2D2 CALB2 HAMP FYB2 NTS OPN5 RAPSN THBS4 TIMD4 ASIP CHRNE CFH CNTFR PRG4 COMP CP PMC3590362__F1 AGE/RAGE signaling pathway in NetSlim- This map represents the NetSlim reactions of AGE/RAGE signaling pathway in different cell types FOXO4 PRKCZ CHUK REN ATF2 EGFR SMAD2 MSR1 INS MAPK14 EZR IRAK4 MYD88 INSR PRKCA MMP7 MMP2 SRC CASP9 HEL-S-44 NOS2 SP1 JUN HEL70 MMP9 ARHA HRAS FOXO1 IKBKB CASP3 ALPL NFKBIA MMP14 PRKCB NFKB1 RELA TIRAP DDOST CYCS CDC42 STAT3 PMC4972490__F1 BRCA1 and BRCA2: different roles in a common pathway of genome protection PALB2 RNF8 ATM TOPBP1 BRCA2 BRIP1 MDC1 RAD52 RAD51 ATR H2AX BRCA1 PMC6335777__F2 Ketamine on the glutamatergic synapse EEF2K MTOR BDNF RHEB HEL-S-162eP PMC2675030__F3 Steps in the generation of Th17 cells IL21R RORA IL23R STAT3 PMC9218220__F3 Reactive Oxygen Species and Metabolism in Leukemia: A Dangerous Liaison NOX3 DUOX1 PDK2 DUOX2 NOX4 NOX5 CIT HEL-S-162eP PMC3023199__F3 PPARG ligand treatments increase expression of mitochondria-associated metabolic pathways in adipose tissue BCAT2 TRO PCCA EHHADH ALDH2 PMC4862319__F1 Simplified schematic of signaling junctions that integrate the recognition of pathogen, host or environmentally derived DAMPs and dAMPs by their cognate receptors HMGB1 TBK1 CGAS TLR9 IRF7 NLRP1 IRF3 MYD88 TLR3 NLRP3 IL16 TLR7 TLR4 AIM2 IL1B MAVS IFI16 PMC3023199__F4 Dysregulated expression of fatty acid and cholesterol synthesis genes in liver is reversed by PPARG ligand treatments SQLE PMVK ACACA MVK POR GPAM HEL-S-5 PMC5727914__F5 Interferon signaling in HPV-containing keratinocytes TBK1 CGAS IRF7 IRF9 EGFR IFNGR2 IRF3 IFNAR2 IFNAR1 IFNG STAT1 IFNK TYK2 JAK1 IFNGR1 IRF-1 PMC3142627__F1 Procession to Pediatric Bacteremia and Sepsis: A Series of Covert Operations and Failures in Diplomacy LTA NOD1 APC CR1 NOD2 PMC4394435__F1 The ubiquitination pathway UBA6 RNF6 TRAF6 UBE2B UBE2D2 NEDD4 SKP2 PMC4394435__F2 The SUMOylation pathway CS SAE1 RANBP2 PMC8894020__F5 Quantitative Proteomics Analysis Expands the Roles of Lysine Beta-Hydroxybutyrylation Pathway in Response to Environmental Beta-Hydroxybutyrate LARP1 ARIH1 TFRC FLNB HEL-S-69 MAGOH KLHL42 RANBP2 PNPT1 HEL-S-2a HEL-S-94n PALLD PTPN11 HEL114 ESD SPCS2 MSH2 EIF4B SPC25 FASN RBPJ HCFC1 NONO EEA1 MTCH2 THOC1 ZC3H11A HSPG2 RPS25 RPL29 ATOX1 YY1 GEMIN5 PMC4424773__F2 Proposed signaling pathway for fat taste TRPM5 STIM1 CD36 PMC7367654__F7 Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway SIRT1 SIRT3 PMC8879981__F1 Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy MCC MSC GAA PMC5757547__F2 Glucose-lipid crosstalk in diabetic kidney disease MTOR TG NR1C1 SIRT1 PMC3321211__F4 Apoptotic cascade CASP3 CASP9 PAF1 BAX PMC8033373__F4 Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study TH PLTP PMC9689226__F8 Overcoming Anxiety Disorder by Probiotic Lactiplantibacillus plantarum LZU-J-TSL6 through Regulating Intestinal Homeostasis MLNR HEL-S-62p APELA UTS2R APLN GRPR TAC3 GIP CALCR LPA GCG VIP TRPV1 MLN NPY TACR3 LEPR TRHR GAL HCRT SST SCT PMCH NR3C1 PRLHR NTS PTH SCTR LHB TACR2 PRL GHRH NMU LEP TSHR CRH OXTR TRH UTS2 AVP OXT FSHR NPFF PMC4427070__F12 Summary of the three-way interaction among AMPK, SIRT1, and eNOS.Notes: AMPK and SIRT1 exhibit a bidirectional interaction in response to cellular energy status and regulate lipid metabolism and inflammatory status IL6 NR1C1 SIRT1 PMC6767293__F4 Effect of corilagin on the TGFB signaling pathway in ovarian cancer SMAD2 MDM2 PCNA PMC6071523__F8 Schematic illustration of the crosstalk between CAFs and cancer cells in the tumor microenvironment PMC4118286__F1 Major physiological functions of the endoplasmic reticulum and their perturbations cause ER stress and activate the unfolded protein response ATF4 EIF2A PMC12127259__F2 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw SHOX SOCS3 SHOX2 PCDH10 PMC6767293__F3 The effect of corilagin on the Notch-mTOR signaling pathway in cholangiocarcinoma MAML1 NOTCH1 MTOR HES1 PMC4061161__F1 The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment HGF GRB2 SRC RHO MTOR CRK CRKL STAT3 PMC12127259__F3 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw VEGFA HEL113 PMC12127259__F4 Photo shows the signaling pathways in which each long non-coding factor interacts through the Hedgehog signaling pathway (By Figdraw PTCH1 SMO PMC3035824__F5 Mapk signaling pathway from KEGG MAX MAFK HEL-S-11 EGFR PMC4287242__F5 Signaling pathways associated with capacitation-related proteins PRKCI GPX4 SUCLA2 NOS2 SP1 ACRBP RHPN1 RAB2A BLZF1 ACR HEL-S-162eP PMC3955735__F5 Glucose and glutamine metabolism is altered by oncogenic K-Ras ME1 GOT2 HEL-S-30 ENO1 RPIA RPE HEL-S-133P GLUD1 GFPT1 HK2 GLS PMC6202151__F7 Schematic depiction of proposal mechanism by which AF confers anticancer actions in TamR breast cancer cells ITGB4 ITGA6 SRC BAX PMC5828949__F2 The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin FGFR1 DPP4 TGFBR1 PMC8507250__F8 Nanoselenium transformation and inhibition of cadmium accumulation by regulating the lignin biosynthetic pathway and plant hormone signal transduction in pepper plants CD2 CAD PMC9267745__F6 VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer NFE2L2 VEGFA MTOR PMC9414852__F8 MOBT Alleviates Pulmonary Fibrosis through an lncITPF–hnRNP-l-Complex-Mediated Signaling Pathway SMAD2 FMN1 HNRNPL SMAD4 MEF2C PMC3365812__F3 Hh signaling pathway and their inhibitors SUFU MYC SMO PMC11502918__F5 An intricate relationship between ER stress and lncRNAs: bidirectional relationship between ER stress and lncRNAs in the context of the UPR pathway ATF4 XBP1 PMC6052836__F1 The regulation of the anti-viral signaling pathway CGAS PIN1 TLR9 IRF7 TRAF3 TRAF6 IRF3 PTEN MYD88 TLR3 TLR7 AIM2 IFI16 PMC11502918__F6 LncRNAs in ER stress-driven HCC progression BAD ATF4 PMC7830727__F1 Ferroptotic cell death pathway GPX4 FTH1 FTL PMC11502918__F4 Diverse lncRNA-medicated signaling pathways targeting different hallmarks of cancer (lncRNAs written in black and red color represent oncogenes and tumor suppressors, respectively) MCM3AP TUG1 MTOR SOX4 PMC7830727__F2 Necroptotic cell death pathway TRADD TRAF1 TRAF2 FADD MLKL PMC11502918__F1 Various stress at ER levels causes the induction of UPR pathway ELF2 ATF4 XBP1 PMC7830727__F3 Canonical, non-canonical, and caspase-3-dependent pyroptotic cell death pathway NLRP3 NLRC4 NLRP1 AIM2 IL1B GSDMD DFNA5 PMC8771506__F6 POU4F3 Acts as a Tumor Suppressor in Lung Adenocarcinoma via the Endoplasmic Reticulum Stress Signaling Pathway ATF4 EIF2A POU4F3 PMC3936289__F4 Major crosstalks between the PI3K and the MAPK cascades TSC2 RICTOR MYC GRB2 EIF4E MTOR IRS1 PMC11205484__F2 Biosynthetic Pathways of Protectins and Maresins in Macrophages and MaR-2 in Brown Adipose Tissue Activation CCR2 HP LGR6 COCH PMC8584803__F1 Biochemical Markers for the Diagnosis of Mitochondrial Fatty Acid Oxidation Diseases HEL-S-62p CPT2 PMC6189190__F5 The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition NF1 CD14 MAX TRADD STS FLNA GRB2 TRAF6 ECSIT TNF TRAF2 JUN PMC7887571__F1 a) Schematic illustration of the HCJSP prodrug nanoparticle prepared via the host–guest interaction between HA‐CD and AD‐SS‐JQ1 and AD‐SS‐PPa HEL-S-133P HK2 BRD4 PMC5804041__F2 PPARA-RXR signaling pathway NR0B2 SHE RXRG NR2F1 IRS1 NR1C1 CHD5 RXRA GRB2 NR1C2 PPARG JUN FASN PMC7399876__F1 Tax activation of canonical and noncanonical NFKB signaling CADM1 PDLIM2 RNF8 CYLD TRAF6 MAP3K7IP1 PMC6130939__F11 GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation required for PI3KG/PREX1 signaling and robust T cell cytokine secretion CXCR4 SRC PREX1 ADRBK1 PMC4669719__F8 Schematic diagram of the NRG1-ERBB4-NRG1 autocrine pathway ERBB4 ERBB2 NRG1 PMC5509685__F1 Simplified sphingolipid metabolic pathway SGPL1 SPHK1 SPHK2 GLS PMC5400657__F1 Long non-coding RNAs: a rising biotarget in colorectal cancer ERBB4 ZEB2 MYC CD44 CREB1 BCL2 TCF7L2 EIF4A3 CTNNA1 PMC8488354__F4 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease ChAT GAA STAT3 PMC8040296__F7 PI3K-AKT Signaling Pathway TH TNC MYC OSM IRS1 PMC8040296__F8 Protein-protein interaction in the PI3K-AKT signalling pathway and ECM-receptor interactions F2R LPAR1 COL1A1 OSMR FLT1 FGF23 COL1A2 VWF THBS1 EN1 SGK1 ITGA2B PDGFRA VEGFA IL6 THBS4 TNC PDGFC THBS2 THBS3 IL2RA LAMC1 COL4A2 AKT3 GNB4 PMC8488354__F3 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease GSK3B APP PMC4961262__F1 The SDF1/CXCR4 signaling pathway TH FGFR1 TBX1 FGF8 SHH TBXT ROBO1 PMC3694992__F1 Neuroimmune Signaling: A Key Component of Alcohol Abuse CD14 HMGB1 TLR4 TIRAP PMC3798191__F5 The relationships between the RA, FGF and Notch pathway in Xenopus PSM CELF1 RBPJ FGF8 PMC5278230__F7 Proposed mechanism underlying HSYA-SDT-induced autophagy and inflammation inhibition in THP-1 macrophages SI MTOR DKFZp686F0183 PMC8449655__F1 De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3‐hydroxylase with 2‐hydroxylase side activity FH F3 ENO1 PMC10486718__F1 Schematically representing the signal transduction and biological activities induced by androgen in ER-positive breast cancer cells EGF SRC RAC1 SGK1 PMC4461014__F5 Dual function of genes BAMBI MMP9 APC SOST VEGFA MYC CER1 ARHA TNF DAAM1 TLR4 MMP2 TIMP3 THBS1 PMC10486718__F2 Schematically representing the signal transduction and biological activities induced by androgen in ER-negative breast cancer cells EGF PAK1 SMAD2 SRC TLN1 RAC1 SGK1 PMC10486718__F3 Diagram illustrating the androgen-mediated signal transduction via integrins and the resulting biological activities MUC1 MTOR TF PMC9354823__F1 Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy PDC OGA ACSS1 OGT FH ACSS2 ACLY HEL-S-162eP GLS PMC6603400__F1 Diagram of ellagic acid target proteins from the DrugBank database SQLE CSNK2A1 CA14 CA3 CA9 RPTOR PRKCA PLN RICTOR PRKCB BASH HEL-S-11 SYK CA4 CA12 CA7 TRIO PMC10874560__F3 Representative bacterial-origin immunostimulants signaling pathway TLR5 TLR4 TLR9 NLRC4 HP IRF7 IRAK1 TRAF6 IRF3 MYD88 MPL TIRAP PMC8291481__F4 Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain TH ChAT PC CHDH ACHE PMC6878604__F1 FGFR pathway.FGFRs dimerize upon ligand building and trigger a downstream cascade of signaling pathways FGFRL1 FRS2 GRB2 PMC3365812__F1 Wnt/Beta-Catenin signaling pathway and their inhibitors APC GSK3B MYC LRP5 LRP6 BCL9 PMC2270852__F5 Schematic of signaling pathways in PDAC EGFR SMAD4 PTEN MTOR STAT3 PMC5819921__F4 Bioinformatics prediction of genes interacting with RAC1 using Ingenuity Pathway Analysis HEL-S-125m BAD LAMB4 WNT4 BIRC5 LAMB3 RAC1 CASP8 LAMA3 CTNNA2 PAX8 PMC9437975__F7 Integrative analyses of mRNA and microRNA expression profiles reveal the innate immune mechanism for the resistance to Vibrio parahaemolyticus infection in Epinephelus coioides CS PERP CFH HEL-S-11 BCL2 CD40 CCL2 PMC6250852__F1 Oxidative stress and activation of Cerebrovascular Endothelial Cells TLR4 VCAM1 ARHA MYD88 IL1B PMC3865646__F2 Apoptosis by hypothermia CASP3 CASP9 CASP8 PMC8905719__F5 RAS pathway regulation in melanoma GRB2 PTPN11 SOS1 PMC4461014__F1 Dual function of TAK1 TRAF6 MAP3K7IP1 TAB3 PMC3132106__F1 Summary of the extracellular interactions between Wnts, Wnt receptors and Wnt regulatory proteins MUSK RYK PMC3176435__F2 Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants AGO4 PMC10742473__F4 Canonical and alternative signaling pathways in B-cells BTK BCR BASH LYN SYK PLCG2 MTOR CD19 PMC7494657__F4 Networks under “Pathways in Cancer” that were enriched in Masquelet bone PRKCZ GNG13 WNT16 GNB5 WNT9B TGFBR2 ADCY3 NOTCH3 EDN1 GNB3 EDNRA EDNRB FZD2 CCND1 SMO BDKRB2 WNT5B WNT7B PMC10150004__F1 Infection routes, invasion mechanisms, and drug inhibition pathways of human coronaviruses on the nervous system TH DPP4 CXCL10 CXCL9 CCL4 CCL2 ACE2 TMPRSS2 PMC2769198__F2 Smad4: gatekeeper gene in head and neck squamous cell carcinoma EGF HGF SMAD4 PMC7658242__F8 IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling ATF4 PMC3201689__F1 Diagram illustrating the DNA base excision repair (BER) pathway FEN1 APEX1 LIG1 PMC6058973__F2 Regulation of GPCR signaling STAT1 XBP1 IFNG PMC5655209__F8 Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10 IGF1 GPC3 GRB10 PMC2427358__F8 Summary of GRTH impact in apoptotic pathways in germ cells BAD TRADD TRAF2 FADD PMC6314240__F2 TGFB signaling as well as the role of TGFB signaling pathway in cancer onset and progression SMAD2 SMAD4 RHO MTOR PMC6617169__F2 Signaling pathways involved in the protective effects of tea bioactive compounds against cardiovascular diseases EP300 NCOA6 PTEN TRPV1 BAX PMC2424295__F2 Feedback loops in NFKB signaling TLR4 IRF3 MYD88 PMC3775269__F6 CTLA4Ig inhibits effector T cells through regulatory T cells and TGFB APC CD80 IFNG PMC4373383__F1 Network of HMGA regulatory mechanisms in human carcinomas HMGA2 TGFBR3 PPP2R2A HMGA1 PMC5310720__F1 PD genes and autophagy-endolysosomal pathway(s) VPS35 PINK1 SYNJ1 FBXO7 SYT11 SMPD1 WDR45 PMC6854084__F6 Proposed model for apoptosis suppression via R-Ras pathway by RasGRP2 HK2 BAX PMC8966724__F2 Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury TBK1 NLRP3 CGAS TLR9 IRF3 BAX PMC8196476__F3 Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis NLRP3 IL18 TLR7 IRF7 IRF3 MYD88 ACE2 TLR3 PMC11050413__F10 Mechanistic map illustrates the role of NDUFA6-DT as a sponge for miR-455-3p in gliomas, disrupting its ability to suppress YWHAH/YWHAG expression BAD CDC25B YWHAG PMC9605422__F9 Research Progress on Fungal Sesterterpenoids Biosynthesis BTC IPP PMC3196210__F2 Relationships of different neurons in the striatum and neurotransmitter signaling involved in interval timing GC NACA BDNF PMC2647704__F5 Schematic of selenoprotein synthesis SLA PSTK PMC9688625__F7 Targeting Wnt/Beta-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF GPX4 IFNG PMC8233150__F8 A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1 TBK1 TRAF6 IRF3 MYD88 PMC3180925__F1 Wnts signal through a “canonical” pathway involving Beta-catenin mediated transcriptional regulation (at left) and through “non-canonical” pathways involving calcium and Rac/JNK-mediated signaling (at right) APC PMC11668870__F2 TRIM14 plays a double-edged role in cancer TBK1 CGAS TRIM14 DVL2 TCF19 IRF3 MTOR FUS STAT3 BAX PMC11668870__F3 Emerging discoveries on the role of TRIM14: from diseases to immune regulation NLRP3 TRIM14 TNF PMC11724432__F4 Mitochondrial Apoptosis and Inflammation NLRP3 CGAS APAF1 IRF3 PMC7407293__F1 Nuclear factor-kappaB (NF-kappaB) signaling pathway BCR RELB CD40 PMC11668870__F4 Expression of TRIM14 is upregulated in response to inflammatory stimuli, subsequently enhancing the expression of pro-inflammatory factors TRIM14 TLR4 KDM4D USP14 RELB BRCC3 TNF OPTN RNF125 PMC11668870__F5 Emerging discoveries on the role of TRIM14: from diseases to immune regulation STAT1 CGAS TRIM14 IRF7 USP14 IRF3 PPP6C MAVS PMC7481463__F6 Biomarker metabolites network based on intelligent pathway analysis use IPA analysis P2RX7 UNK IL6 PMC9273868__F5 Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform PTPRC KCNB2 KCNS3 STUB1 NR3C1 HEL-S-44 VCP TRAF2 ADRA2B P2RY14 PMC7046484__F8 Schematic illustration summarizes the epiregulin promoted trophoblast cells invasion by targeting poFUT1 and O‐fucosylation on uPA, which stimulated PI3K/Akt signalling pathway and MMP 9 activity POFUT1 PLG MMP9 EGFR CDH2 PMC8674574__F2 Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI NLRP3 SH3YL1 TLR4 RIPK3 NOX4 IL1B MLKL GSDMD BAX PMC8557391__F2 Nrf2/Keap1/ARE signaling: Towards specific regulation MAF KEAP1 PMC7961726__F2 Representation molecular mechanisms underlying the tumoral properties of glioma cells TNFSF6 DGCR8 FOS EGFR PTEN PMC11594620__F1 Metabolic pathway of complex sphingolipids in budding yeast Saccharomyces cerevisiae GHB3 ORM2 ORM1 PMC3784667__F2 Intracellular cycling of MUC1MUC1 is phosphorylated by EGFR and other receptor tyrosine kinases MUC1 EGFR SRC PMC3912412__F6 Interaction of CLL cells and the lymph node microenvironment DUSP4 FOS CXCR5 CD83 TNF CD72 CD22 FOSB JUND JUNB DUSP2 FCGR2B TNFAIP3 IL1B PMC12015243__F6 EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway TIMP1 MYC CCND1 STAT3 PMC6315659__F2 Regulation of the Hippo/YAP signaling pathway in malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) EGF NF2 EGFR LATS1 LATS2 PMC8396181__F2 Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects FUZ MYH10 HECTD1 PMC6160868__F1 Wnt/Beta-catenin driven mevalonate metabolism promotes EMT PMVK MVD FDPS MVK HMGCS1 ACLY IPP HMGCR PMC7695367__F7 The proposed mechanism of radiation-induced tumor repopulation in NSCLC CASP3 ATM H2AX PMC7014214__F2 Anticancer mechanisms of phytochemicals on gastric cancer ATG12 MMP2 ATF4 NOTCH1 ATR PMC2597223__F1 Pathways of apoptosis ARC FADD BAX PMC11717529__F7 Mechanism of action of hsa_circ_0109623 and hsa-miR-146b-3p and their downstream target gene SORT1 in the pathogenesis of AIH SORT1 STAT1 STAT4 PMC7977493__F8 Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling RUNX2 APC RHO SMAD1 DKFZp781O1323 PMC3765909__F2 Mechanism of blockade of the Wnt signalling pathway by osteocytes LRP5 LRP6 PMC2974212__F3 Critical growth factors and signalling pathways controlling human trophoblast invasion EGF HGF RHO MTOR PMC7294938__F3 Mechanotransduction and pathways regulating cytoskeleton during metastasis PIEZO2 PIEZO1 ARHA MTOR PMC7083089__F4 Secondary structures at CFSs can impede replication, resulting in fork stalling and cleavage to cause fragility SLX4 ATR PMC6711159__F1 Closer Look at Pyroptosis NLRP3 IL18 TLR4 S100A8 TRAF6 MYD88 IL1B PMC6020732__F2 AhR in breast cancer and the role of dietary compounds COX2 AHR CYP1B1 PAH BRCA1 TDO2 PMC4486131__F5 OFE treatment counteracted TGFB1-activated SMAD pathways CDH11 SMAD2 CDH2 PMC8345973__F1 Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease DAO PMC7412635__F7 The dichotomous effects of VCD on follicular development NOBOX PTEN RPS6 PMC8942302__F3 STAT3 pathway in cancers: Past, present, and future SOCS2 EGF COX2 TLR4 SOCS3 TLR9 EGFR SRC OSM SOCS1 STAT3 PMC4022607__F1 Angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development TEAD3 AMOTL2 AMOTL1 TEAD4 LATS1 COIL LATS2 TEAD2 PMC4453519__F3 Activation of the cytokine-cytokine receptor interaction pathway in incubations with BL21 or W3110 IL10 CCR6 VCAM1 TNFSF10 ACVR1B IL8RB FLT3 TNF CSF2 TNLG5A TNFAIP3 BMP4 PMC4987729__F2 Processing of engulfed dying cells requires LC3-associated phagocytosis (LAP) and promotes an anti-inflammatory response ATG12 ATG3 RAC1 ABCA1 UVRAG DKFZp686F0183 GABARAP PMC11704872__F4 The IGF-1 Signaling Pathway in Mitophagy NRF1 IGF1 BNIP3 PMC11279976__F2 Common metabolic pathways of NAD+ and NMN NAPRT NAMPT HEL-S-90n NMNAT1 NMNAT2 NNMT NMNAT3 NRK PMC11704872__F3 Inhibition of autophagy by the IGF-1 signaling pathway TSC2 ULK1 BAD TSC1 IGF1R IGF1 IGF2 ULK2 DEPTOR IRS1 RHEB PMC2754696__F1 CIE and CDE pathways showing lipid content and regulatory molecules EHD3 SRC ARF6 CDC42 PMC8393605__F2 Exploring the Interplay of Telomerase Reverse Transcriptase and Beta-Catenin in Hepatocellular Carcinoma APC GSK3B KLF4 TCF4 TERT PMC10218028__F2 SNPs affecting NET formation TMPRSS13 MPO KIF26B SYK TNFAIP3 PMC9151343__F1 Metabolic engineering of Vibrio natriegens for anaerobic succinate production PTS CS FH CIT MAL PMC12080488__F4 Figure illustrates the JAK/STAT signaling pathway and its role in cancer progression, highlighting its influence on tumor invasion, progression, autophagy, and apoptosis TWIST1 GSK3B IL6 JUNB STAT3 PMC6529540__F3 Omics analysis discovered high-confidence networks involved in AD UBC PIK3R1 HSP90AB1 APP PMC10962118__F9 Mechanistic map of PELI1 ubiquitination of RPS3 activating the PI3K/AKT/GSK3B signaling pathway, promoting p53 degradation, and thus facilitating progression in PC MDM2 PELI1 RPS3 PMC6359191__F1 Cartoon representing the osteolytic and osteosclerotic vicious cycles EGF WNT3A IGF1 SOST WNT1 IL11 IL6 PMC10851593__F4 Lignin synthesis pathway map INS CAD PMC6348604__F1 Apoptotic signaling pathway BAD BCL2 BAX PMC5542661__F1 Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge ATP6V0A2 ANXA3 RGS12 PFKM HRAS DUSP19 TMEM185B SIAH1 TMEM185A RAP1A CISH JSRP1 QRICH1 ADARB1 UNK EBNA1BP2 DYRK2 C1orf21 RB1CC1 PMC5041942__F2 Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression VEGFA LSM2 PMC7505161__F3 Toll-like receptor 4 (TLR4) activation in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection TLR4 IL6 ACE2 PMC3328281__F1 Molecular changes of serous carcinogenesis BRAF ERBB2 DOCK4 PIK3CA RB1 CDKN2A BRCA1 CCNE1 PMC9501394__F2 Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review KEAP1 BCL2 BAX PMC11727388__F4 Aberrant tumorigenic ECM modulates several intracellular signaling pathways involved in tumor development and progression AMOT PIEZO1 NF2 SMAD2 APC GSK3B CD44 HEL-S-15 SMAD4 SRC RHO MTOR PMC2224766__F3 Proposed metabolic pathway for PSI-6130 CDA DCTD PMC2825553__F1 Interplay of cellular stress signals with apoptosis pathways FADD BAX PMC8253836__F1 Consolidated bioprocessing for bioethanol production by metabolically engineered Bacillus subtilis strains PTS PDC MALL PMC9584705__F8 Methylation-Mediated Silencing of RBP7 Promotes Breast Cancer Progression through PPAR and PI3K/AKT Pathway PTEN RBP7 TF PMC2739091__F8 Schematics of the effect IL-1B on the alveolar capillary barrier ARHA IL1B PMC7016983__F2 Metformin (MET) AMPK dependent signaling TSC2 PML ULK1 TFEB EIF4E CAD MTOR EIF4B RHEB PMC7216182__F6A BST Stimulation Induces Atrophy and Changes in Aerobic Energy Metabolism in Rat Skeletal Muscles—The Biphasic Action of Endogenous Glucocorticoids CORT HSD11B2 HSD11B1 PMC9457820__F6 Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges APC GSK3B IL6 PMC2631033__F1 Tumor necrosis factor and cancer, buddies or foes? CASP3 TRADD CASP9 TNF TRAF2 FADD PMC9657218__F4 Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress ATM RAD52 RAD51 PARP1 DNA2 PMC6498051__F7 IFNG pathway associated with differentially expressed genes between SRHIC and WRHIC purified CD8 T cells AK2 IRF9 TYK2 JAK1 IRF-1 SOCS1 IFNG BAX PMC9674404__F3 Signaling condensates in the B cell receptor pathway BCR SYK COIL PMC8699740__F2 Integrin AE(CD103)B7 in Epithelial Cancer PLCG1 RUNX3 HEL-S-28 ITGAE TGFBR1 CD69 CCL3 PMC7069516__F14 Interrupting cyclic dinucleotide-cGAS–STING axis with small molecules TBK1 CGAS IRF3 PMC6426138__F6 Ciliary TGFB/BMP signalling SMAD2 TGFBR1 SMAD4 SMO SMURF1 SMAD1 DKFZp781O1323 PMC8942302__F6 STAT3 pathway in cancers: Past, present, and future EGF EGFR SRC STAT3 PMC3423475__F9 Animal oral and veg1 ectodermal GRN for sea urchin embryogenesis NODAL GSC PMC4743530__F3 Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis MESP1 APC PMC11050262__F14 Cytotoxic effect of cisplatin on the HT-29 cell line based on gene expression and pathway analysis BAD APAF1 PMC8166571__F1 Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on Δ-5/Δ-6 Desaturases and Elongases 2/5 FADS2 ELOVL5 FADS1 ELOVL2 GLA PMC9619038__F1 Editorial: Sirtuins and brain homeostasis NLRP3 SIRT2 IL16 SIRT1 SIRT3 PMC4997943__F2 CEACAM6 Signaling Pathway VTN SRC CEACAM6 PMC8016635__F3 Impact of PERK signalling activation on osteoclastogenesis NFATC1 ATF4 EIF2A RAC1 PMC8016635__F1 Brief diagram of the PERK signalling pathway KEAP1 GCLC ATF4 EIF2A MTOR FOXO1 INSR PMC11580516__F3 Key Mechanisms of Metabolic and Immune Modulation in the Tumor Microenvironment EGF IGF1 EGFR MTOR PMC8016635__F2 Downstream changes caused by activation of PERK on osteoblastogenesis RUNX2 NFATC1 ATF4 EIF2A DKK2 DDR2 FOXO1 PMC3999173__F2 Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells CXCL13 LTA AHR CCL21 MYD88 IL23R LTBR PMC11580516__F4 Molecular Mechanisms of Breast Cancer Metastasis, Drug Resistance, and Target Organ Selection PIGF IGF1 MMP2 MMP9 IL33 CCL2 IL4 CXCL12 IL25 TSLP IL1B PMC6039966__F3 The AhR genomic pathway AHRR AHR SRC PMC7599061__F1 Schematic process of the SARS-CoV-2’s internalization, proliferation in the cell, and influence on RAS ACE2 TMPRSS2 PMC8835793__F3 Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential IGF1R IGF1 RHEB MLST8 PMC4507501__F1 New targets in cancer cell metabolism are shown HEL-S-26 PGAM1 PMC4392459__GA Propane synthesis derived from a fermentative butanol pathway is enabled by metabolic engineering AHR HBD PMC8466366__F1 Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat Stresses MID1 CS CDC42 PMC2075035__F4 Scheme of the LNB/GNB pathway in B GAL PMC5470086__F1 Intestinal FXR and TGR5 signaling in metabolic regulation CYP27A1 CYP8B1 CYP7B1 FGFR4 CYP7A1 PMC2075035__F2 Scheme of the Leloir pathway PMC7829888__F4 Alternative growth factor driven signaling pathways after androgen blockade EGF SRC IL6 PTEN JAK1 STAT3 PMC6516512__F1 Major steps in the catabolism of BCAA BCKDK PPM1K BCAT1 BCAT2 FASN PMC12034555__F1 Biogenesis of exosomes depends on two pathways ESCRT dependent and ESCRT-independent TSG101 LIMK1 CD63 ROCK1 EGFR TBC1D2B RAB31 CHMP3 VPS28 VPS36 TBC1D28 PMC1860592__F2 Biologic therapies: what and when? CD80 CTLA4 PMC12034555__F2 This figure shows the role of EV-associated proteins in TNBC progression through various molecular interactions: 1 EGFR CD44 NOTCH1 CCL5 ADAM10 CD24 PMC7565467__F2 Key components of the Ca2+signalling machinery in the control of cell proliferation and the cell cycle FOS MYC ARC RB1 JUN ORAI1 STIM1 PMC8809092__F7 Suppression of canonical TGFB signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis SMAD2 SMAD4 ME3 GATA4 PMC3594938__F5 Cell type-specific outcomes of KSHV interactions with CD36 and CD147 signaling pathways FYN LYN MTOR CD36 PMC12034555__F3 EVs derived from TNBC cells line can transfer various biomolecules to recipient cells, thereby modulated their biological functions NCL FOXM1 MSC EGFR BCL2 ANXA6 STAT5B RAG2 PMC4635569__F1 Proteins used in this study HEL-S-62p CFH FH PMC11512255__F6 Schematic model illustrates the mechanism by which HSV-2 UL24 blocks the IRF-3 signaling pathway TBK1 IRF3 MAVS PMC11580516__F1 Metabolic Reprogramming and Drug Resistance in Breast Cancer SDHC ACLY MTOR DEPTOR HK2 STAT3 GLS PMC6776918__F1 Mechanisms linking HPA axis dysregulation and AD CRH GC AVP APP PMC11580516__F2 Metabolic Reprogramming of Immune Cells in the Hypoxic Tumor Microenvironment IL16 CXCL2 TNF HIF1A ARG1 HDAC1 IFNG STAT3 PMC10308769__F1 First reported double drug–drug interaction in a cancer renal patient under everolimus treatment: therapeutic drug monitoring and review of literature TSC2 RICTOR ULK1 TSC1 PTEN MTOR DEPTOR IRS1 RHEB MLST8 PMC1852756__F2 The small nuclear ribonucleoprotein biogenesis pathway TGS1 GEM RAN PHAX PMC3608184__F1 Cardioprotective mechanisms of T3 HIF1A MTOR PMC8060499__F1 Possible involvement of the complement system (CS) in the recruitment of neutrophils and the formation of NETs in Alzheimer's disease CS CR1 PMC3837441__F7 The Cdc42-dependent regulation of neural differentiation in P19 cells HES5 MTOR CDC42 PMC3722174__F8 Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network TSC1 LARGE NRF1 HIF1A IRS1 TFAM SIRT1 FOXO1 RHEB PMC1914109__F8 The p110D → RhoA → PTEN signalling pathway described in the text HEL-S-62p SRC PTEN PMC4967210__F5 Ingenuity Pathways Analysis of the effects of TXNIP deletion KDR CDKN1A TXNIP FASN PMC5979596__F3A GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance FYN CDK5 PMC6391732__F3 Notch signaling pathway as seen in the KEGG database (hsa:04330) HES5 NUMB HES1 PMC7395689__F1 Figure describes the process by which AVB3 mediates prostate cancer cell metastasis SPARC CXCL16 RUNX2 SRC SAMD5 CCL2 MTOR CTGF PMC2453100__F7 The activated PI3K-AKT pathway and its downstream effectors that contribute to the tumorigenesis of TSHomas in TRBPV/PV mice BAD GSK3B CCND1 MTOR PMC11900819__S4 Proposed organization and role of adenosine receptors in mitochondria GSC PMC3022823__F9 FBPA clustering on gene expression in the bystander response HEL-S-62p CEBPE NCOR1 RELB MYC NFKBIZ IL11 IL12A FOXL2 CEBPB CEBPD ZFP36 MT1E GDF15 CHIC1 SP1 JUN TNFRSF10C KAT2B HOXB7 GADD45G MEOX2 PTGS2 TP63 VAV1 NFE2L2 IRF3 CEBPA CREBBP EP300 CDKN1A RELA KLF2 PMC3022823__F7 FBPA clustering on gene expression after direct irradiation BATF3 PML KDM5B NRF RELB MYC BTG3 SMAD4 CXCL3 NFKBIZ DKK1 FOXL2 SP100 CEBPB CITED2 COX2 AHR MAP10 NOTCH1 HDAC2 ETS2 IRF-1 JUN SERPINB2 IRF2 EGR1 NAB2 MEOX2 FOXO3A BMP2 ERG DACH1 ATF3 CXCL2 IRF3 RELA TP73 KLF2 REL ELF4 TAF4B NFKBIE PMC4774109__F2 Dysfunctional humoral response during visceral leishmaniasis CD27 GC PMC8151274__F4 MiR-21 in the Cancers of the Digestive System and Its Potential Role as a Diagnostic, Predictive, and Therapeutic Biomarker CASP3 BAD APC MSH6 CASP9 SMAD4 MSH3 DCC PMC2997737__F1 AKT/MTOR pathway TSC2 RICTOR TSC1 PDK2 MDM2 PTEN MTOR IRS1 RHEB MAPKAP1 MLST8 PMC7982729__F4 Autophagy-mediated elimination of pathogens TBK1 TLR8 CGAS TLR7 TLR4 IRF7 TRAF6 IRF3 TLR3 PMC12021660__F2 Fat-body metabolic pathway profiling CTRL ACLY PMC8808015__F1 Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article DAAM1 APC GSK3B LRP5 LRP6 ROR2 CA12 ROR1 PMC10040851__F6 Single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections PLSCR1 SRI SOCS3 FITM2 RNF213 KIN WAS CD74 SELL FYN CD163 CMTR1 NMI EIF4E3 MVP NAMPT IRF7 PPL IRF9 CSK POMP SLC25A28 APC PSMA2 CNP PSAP IFNAR2 SLAMF7 IFNAR1 HLA-DRB1 HLA-B HLA-C HLA-F ADAR ARHG MAX PARP12 TNFAIP3 PARP14 IFIT2 IFITM3 CNPY3 RIPK2 CSF2RB HLA-DMA GBP2 PTPN1 SAMD9 CD68 TAF1 STX7 BST2 PS1TP5BP1 OGFR HLA-DQA1 LYN SYK PSME2 PMC9118092__F8 Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling TNFRSF12A FGF6 AQP8 LTC4S MSTN SLITRK4 WIF1 MYL7 CYP2E1 SRXN1 UCP3 PMC9456318__F9 Integrated Analysis of Transcriptome and Metabolome Reveals Distinct Responses of Pelteobagrus fulvidraco against Aeromonas veronii Infection at Invaded and Recovering Stage NLK ATG12 ATM CDK2 MDM2 INS KLF2 PTEN BNIP3 SKP2 PMC9943254__F2 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment SLC7A5 HEL-S-26 PDC FH MYC FASN BRD4 GLS PMC7459801__F1 Processing and trafficking of amyloid precursor protein (APP) through the endolysosomal pathway BACE1 PSEN2 PSEN1 APP PMC3979327__F3 MicroRNA networks regulate development of brown adipocytes HDAC3 MYF5 HOXC8 PMC7766831__F5 Proposed model of the molecular and cellular responses to new replication stress inhibitors SSB PARP1 ATR PMC5376429__F2 Emerging signaling pathways in HCC: chromatin remodeling: restricting transcriptional and DNA condensation occurs as a result of histone deacetylation catalyzed by HDACs in nucleosome TLR4 NF2 ARID2 LATS1 LATS2 PMC9943254__F8 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment SUFU PTCH1 SHH SMO PMC11621776__F4 Important AM pathways MALL CIT MAL PMC11621776__F6 Five signaling pathways associated with macrophage polarization which are highlighted by pink color GYS2 IL33 IFNG PMC2771360__F4 Microglia Are Mediators of Borrelia burgdorferi–Induced Apoptosis in SH-SY5Y Neuronal Cells TIGAR HIPK2 SCO2 JMY GSK3B GML PIGS PTEN WT1 ATM MDM2 CYC1 CDK4 ATR PCNA BAX PMC4770774__F9 Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis IGF1R MSC IGFBP5 KLHL4 PMC8710987__F3 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches HEL-S-104 PMC11979968__F4 Distribution of the seven core targets in the serotonergic synapse signaling pathway and the drug‐pathway‐target‐disease network DDC MMP9 EGFR SHE HTR4 CNR1 PMC9553391__F8 Anlotinib Benefits the APDL1 Immunotherapy by Activating ROS/JNK/AP-1 Pathway to Upregulate PDL1 Expression in Colorectal Cancer FOS CXCL2 JUN PMC5452357__F4 Scheme showed the probably metabolic pathways in patient with PH2 and AGXT2 deficiency PC DAO ABAT AGXT2 PMC6522898__F10 Schematic illustrating the mechanism in which elevated HP induces apoptosis in RGCs through the regulation of the NGF signalling pathway NGF HP FOXO1 PMC6311083__F4 Qualitative Biological Regulatory Network (BRN) of Hexosamine Biosynthetic Pathway (HBP) intersection with PI3K-mTOR-Myc signaling and P53-MDM2 signalling axis OGA FOXM1 OGT MDM2 PMC7784512__F4 Schematic proposed mechanism of inflammatory downstream signaling pathway in lung epithelial cells undergoing hypoxia–reperfusion stimulation TLR4 MYD88 IL1B PMC4609742__F9 Model depicting the functional interplay between PPM1G, the 7SK snRNP, and ATM kinase during the activation of the NFKB transcriptional program in response to DNA damage MEPCE LARP7 ATM PPM1G POLI PMC9231409__F1 Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options TBK1 STAT2 IRF9 IRF3 NUP62 IFNAR1 TRIM25 TLR3 STAT1 ISG15 NUP98 TYK2 NXT1 MAVS PMC5512163__F2 Biologic and Clinical Perspectives on Thyroid Cancer RET BRAF NTRK1 NTRK3 MTOR tal-1 PMC5216790__F6 Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with Beta-catenin-dependent and Beta-catenin-independent signaling pathways WNT3A FZD2 MYC LRP6 ROR2 ROR1 PMC9166437__F1 TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target PLCG2 APOE PMC11130926__F1 Bacterial Q de novo and salvage pathways QTRT1 QTRT2 QNG1 PMC5512163__F3 Biologic and Clinical Perspectives on Thyroid Cancer RET BRAF EIF1AX MTOR TERT PMC6066558__F4 Soluble klotho pleiotropic functions and FGF23 – sKlotho interactions FGF23 IGF1R TRPC6 FGFR4 PMC11653467__F7 Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis ATF4 XBP1 BAX PMC5395695__F1 Proposed mechanisms of pathogenesis in haploinsufficiency of A20 (HA20), otulipenia/otulin-related autoinflammatory syndrome (ORAS), and linear ubiquitin chain assembly complex (LUBAC) deficiencies RIPK1 TRADD SHARPIN TNF OTULIN TRAF2 PMC8468876__F2 Gamma-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities TH NADK OGDH PMC11149107__F1 HER3 targeted therapies in the clinic and HER3 downstream signaling pathways IGF1R EGFR GRB2 SRC PTEN MTOR PMC8466973__F1 High temperature requirement A1 in cancer: biomarker and therapeutic target EGF PAX2 EGFR NOTCH1 PMC8990718__F6 Serum amyloid A 1 induces suppressive neutrophils through the Toll‐like receptor 2–mediated signaling pathway to promote progression of breast cancer SAA1 MYD88 PMC4770016__F2 ITK acts as a rheostat for the TCR signaling pathway ITK LCK ZAP70 IRF4 CD69 PMC11594203__F6 Differentially expressed genes related to mammary epithelial cell proliferation and milk protein synthesis in the PI3K-Akt, WNT, and mTOR signaling pathways after knockdown of S100A9 in MAC-T cells FOXO3A LRP6 S100A9 MTOR DEPTOR DVL3 TSC2 TLR4 CDK2 LAMTOR2 CCND1 CDC2 SLC36A1 PMC7934064__F2 Mechanisms involved in DDR and checkpoint immunotherapies CGAS ATM PARP1 CCL5 ATR CHEK1 PMC7352439__F2 Metabolic characteristics of M1 and M2 macrophages IL13 IL6 IL4 HIF1A PMC12210716__F1 Jak-STAT signaling pathway STAT1 STAT2 IRF9 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 PMC5845129__F1 Schematic diagram for innate immune response against influenza A virus (IAV) infection TLR7 IRF7 IRF3 TYK2 MYD88 TLR3 MAVS PMC6073271__F1 Simplified diagram of the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway for phytohormone abscisic acid (ABA) biosynthesis with components occurring in the Chloroplast and Cytosol HEL-S-62p IPP PMC8710987__F1 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches F2 RPIA HEL107 RPE ASL HEL-S-5 HEL-S-162eP PMC6032434__F6 Summary and model for the potential function of the chIL-34 signaling pathway STAT1 MAP3K7IP1 SOCS1 STAT3 PMC4086483__F1 NFKB signaling pathway BCR CD40 HEL-S-92n PMC9248717__F2 Wnt Signaling in Postnatal Tooth Root Development CA3 ARHA RAC1 JUN PMC9248717__F1 Wnt Signaling in Postnatal Tooth Root Development APC LRP5 LRP6 PMC7878563__F6 Signaling pathways coupled to the M4 mAChR GSK3B ADRBK1 PMC7878563__F5 Signaling pathways coupled to the M1 mAChR GSK3B ARHA ADRBK1 PMC7192886__F1 Immune responses induced by radiotherapy HMGB1 CGAS TLR4 ATM EGFR ATR IRF-1 IFNG PMC6585493__F2 Transcriptional changes of genes involved in fatty acid catabolism, MVA formation, and energy metabolism by ΔYPL062W, whose reactions mainly occur in the peroxisome (A), cytoplasm (B), and mitochondrion (C), respectively IDI1 IPP PMC9630645__F3 Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives SPR TNC TNF TG TRPV1 PMC5671379__F1 Damage Associated Molecular Patterns in the Pathogenesis of Osteoarthritis: Potentially Novel Therapeutic Targets HMGB1 S100A8 TRAF6 S100A9 PMC9628128__F1 Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications EGF HEL-S-30 F2 APC EGFR MYC PTEN HK2 PMC6346072__F1 Metabolism of sulfur amino acids and H2S synthesis HEL-S-182mP PMC7404291__F4 HSV-1 evasion mechanisms to downregulate the host innate immune response STAT1 CGAS STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 TYK2 MYD88 JAK1 MAVS PMC8595937__F1 Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures ROCK1 CSK VAV1 CFL2 TLN1 RHO RAC1 CRK NCK1 ITK BTK PAK1 FYN RAP1A CXCR4 ZAP70 JAK3 HEL114 PLEKHG2 CXCL12 PXN ACTG1 CDC42 PMC7120249__F1 Immune-related autophagy functions ATG16L1 TLR4 IRGM IL1B NOD2 PMC5512069__F8 The role of BMP4 in regulating hyperandrogenism development SMAD4 CYP17A1 SMAD1 DKFZp781O1323 BMP4 PMC10838060__F6 cGAS-STING and pyroptosis TBK1 NLRP3 IRF3 AIM2 GSDMD PMC10838060__F7 cGAS-STING pathway and metabolic reprogramming PDK2 PDK4 ACOD1 PMC10838060__F4 Other media for activating STING TBK1 CGAS TRAF6 IRF3 PRKDC IFI16 PMC10838060__F8 cGAS-STING and cell senescence in diabetes TBK1 CGAS FANCD2 TREX1 MRE11A PMC10838060__F9 CGAS-STING pathway in diabetic complications TBK1 NLRP3 CGAS PMC6684391__F6 Proposed interaction induced by azithromycin (AZM) is depicted STAT1 TLR4 RELA TYK2 IL6 MYD88 JAK1 IL1B IFNG PMC8830521__F4 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer NLRP3 MMP2 MMP9 PTEN MTOR RPL5 IL1B PCNA STAT3 BAX PMC5606204__F4 Regulated Cell Death Pathways CASP3 APAF1 CASP9 RIPK3 CASP10 CASP8 FADD CASP4 PMC2812385__F7 Alternative mechanisms exist for the induction of inflammatory and apoptotic genes in the absence of the IFNA/B receptor during influenza virus infection PML MGP EGR1 ING1 FOSL1 IRF7 BMP2 MMP9 RELB MYC EIF2AK2 CCL2 STAT1 HOXA13 RELA MDM2 JUNB NOS2 IRF-1 IL1B CASP4 PMC5426484__F3 Network fabricated in CellDesigner RET DAO BDNF CRTC1 PMC1851974__F2 Regulation of cyclin D1 degradation GSK3B CCND1 CDK4 TF CDK6 FBXW8 DYRK1B PMC8830521__F5 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer METTL14 TF BAX PMC8830521__F6 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer COX2 PHLPP2 MYC SMO PMC3789860__F3 Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure ARHA BDNF TRIO PMC3582714__F1 Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function TSC2 RICTOR TSC1 MYC HIF1A RHEB PMC5945848__F8 P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy HEL-S-102 ULK1 P2RX7 SH3GLB1 GSK3B PRKAA1 MAPK1 SP1 COMP PMC4396872__F1 Canonical and noncanonical NLR inflammasome activation STAT1 TNF IL1B PMC5627515__F3 Protein-bound uremic toxins could take use of five potential toxin-conjugated albumin-receptor pathways to either promote or suppress inflammation SPARC SRC ARHA CDC42 PMC4396872__F3 NOD signaling pathways IRF7 TRAF3 IRF3 NOD2 MAVS TAB3 PMC9475348__F6 Human placental mesenchymal stem cells regulate inflammation via the NF‑KB signaling pathway TLR4 IL1B BAX PMC12032003__F7 Working model of G-Rg1’s functions in protecting the synaptic plasticity and mitigating neuroapoptosis via the Hippo-YAP signaling pathway in the stress model TEAD3 TEAD4 LATS1 LATS2 TEAD2 PMC8471828__F6 Ferroptosis Meets Cell–Cell Contacts FACL4 LATS1 LATS2 PMC4206829__F4 Recent advances in understanding colitis-associated tumorigenesis TLR4 STAT3 PMC10788715__F5 MiRNA-766-3p inhibited gastric cancer via targeting COL1A1 and regulating the PI3K/AKT signaling pathway COL4A4 COL4A6 COL4A3 COL6A1 LAMB2 COL2A1 LAMA4 COL1A1 COL4A2 LAMC2 COL4A1 PMC9456412__F2 Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder COX2 COX1 PMC4543753__F4 Transcriptional gene regulatory network in VBL-treated KB-3 cell HEL70 PLP2 CD63 RAB31 AKR1B1 MAGED2 IER3 CDKN1A SDC4 NFKB1 RELA SPHK1 PSMD1 EMP1 ACTG1 KRT14 PSMD11 PMC6249341__F1 Implication of microglia in the development of Alzheimer's disease NLRP3 TLR4 CD33 APP IL1B APOE PMC7737398__F9 Pathways of ES and SR PMC9495382__F2 p53: From Fundamental Biology to Clinical Applications in Cancer ATM CDK4 ATR CDK6 PMC4534355__F5 Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates UBC RPLP0 HEL2 AMOT OFD1 PRPF4 CP PMC4390248__F5 Representative protein-protein interaction networks of key pathways and proteins involved in sperm functions HEL-S-99n PPIB HEL-S-133P CLU PMC7868042__F2 Autophagy in kidney homeostasis and disease PINK1 FUNDC1 BNIP3L FAT10 BNIP3 NBR1 PMC10967382__F5 Altered sphingolipid metabolism and signaling in monocytes and neutrophils during pneumonia SPTLC1 TRAF6 MYD88 TLR1 SPNS2 NLRP3 TLR4 PC SGMS1 UGCG ACER1 SGPL1 ACER3 BCL2 SPTLC2 SPTLC3 SMPD1 SPHK1 RAF1 ABCA1 SGMS2 AKT3 PMC8267750__F4 Fructose and the Liver NLRP3 MYD88 IL1B PMC8714903__F2 Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells ARHA STAT3 PMC4445861__F2 Slit/Robo interactions and their roles in carcinogenesis PI3 HGF MMP2 CXCR4 MMP9 GSK3B GRB2 SLIT2 DCC SLIT1 CDC42 PMC12037536__F5 Multiple cytokines and signaling pathways in psoriasis is highly significant TRADD SMAD2 IMPACT TRAF3 TRAF6 IFNGR2 IRAK4 MYD88 IL17RB IL17RC STAT4 IL17RA TYK2 STAT3 MAL PMC8727737__F2 JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance PTPRT MTOR PMC4024059__F1 STAT3 and epithelial–mesenchymal transitions in carcinomas EGF SOCS3 EGFR OSM OSMR STAT3 PMC3681753__F8 Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses MED12 TANK ARHH HAL TRAF3 TRAF6 TNK2 TFR2 MBD3 SSH3 NEU3 POLR2A PSMC4 ATP2B3 CASP8 SMS HSFY2 SLC38A12 ZFY PCDHB2 VWA2 APC CASP10 FCGR3B THEM5 TRIM25 PLEKHH1 NTF4 ORMDL3 PKD2L1 MC2R PSMD2 TMEM140 FADD SLC29A4 PMC8313795__F1 Chitosan derivatives: A suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus FURIN ACE2 TMPRSS2 PMC6687759__F3 Proteoglycans in cancer-predicted pathway DCN HEL-S-11 EGFR MYC VEGFA CBL PMC5878997__F3 Extranuclear Signaling by Sex Steroid Receptors and Clinical Implications in Breast Cancer EGF CDK2 HBD EGFR GRB2 SRC SP1 TF PMC7559203__F3 KSHV-deregulated NFKB signaling pathway in oncogenesis CXCR4 BCL2 RAC1 EZH2 IRF4 LAT STAT3 PMC7559203__F1 an overview of virus-deregulated NFKB signaling pathway in oncogenesis KL RELB BCL2 ID1 PMC7559203__F2 EBV-deregulated NFKB signaling pathway in oncogenesis GC LYN SMAD4 SYK LAT PMC2949129__F7 Putative signaling pathways leading to translational activation and enhanced MCT2 protein synthesis after BDNF treatment in cultured cortical neurons EIF4E MTOR BDNF PMC8964062__F1 T Cell Metabolism in Infection TSC2 MYC CD80 FOXO1 RHEB HK2 PMC8450894__F2 Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ CD14 TLR4 PMC9132726__F1 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium SUFU GLI3 SHH SMO PMC4563137__F5 Pathway enrichment analysis reveals PI3K/PTEN/AKT signalling and apoptosis pathway as the most significantly related pathway PIK3R1 HEL-S-28 CDKN1B GRB2 PTEN SOS1 ITGB1 SHC1 PDPK1 PMC9132726__F2 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium GPR161 SMO AKAP9 PMC6777507__F2 Activation of serotonin receptors (5-HT-R) initiates a signaling cascade that leads to the activation of extracellular signal-regulated kinases (ERK) APP BDNF PMC9132726__F3 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium PDE4D ANKMY2 ARHGAP36 GPR161 SMO PMC4619565__F7 Parallel activin and TGFB signaling in advanced colon cancer ACVR1 TGFBR1 TGFBR2 SMAD4 PMC6850218__F1 Model illustrating 4 potential roles of RGD-binding integrins in the initiation, development, and perpetuation of organ fibrosis SMAD2 SMAD4 TGFBR3 PMC5527674__F1 “Pushmi-Pullyu” of DNA REPAIR: Clinical Synthetic Lethality CHEK2 WEE1 ATM TOPBP1 MDC1 PARP2 RAD51 PARP1 ATR CHEK1 BRCA1 TP53BP1 PMC7823564__F1 NFKB canonical and non-canonical pathways EGF EGFR LTB RELB CD40 LTBR PMC8247594__F2 Evolution of Our Understanding of XIAP Deficiency BCL10 RIPK2 MAP3K7IP1 PMC8247594__F3 Evolution of Our Understanding of XIAP Deficiency CAP1 RIPK3 DAP RAC1 TNF IFNAR1 MAP3K7IP1 NOD2 NLRP3 CAP2 TLR4 SYK TRAF2 FADD TAB3 PMC8306787__F3 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance LOXL2 IL18 EGR2 ATF4 CRTC2 PMC3819805__F11 Folate biosynthetic pathway in Plasmodium falciparum DHFR DHPS PMC7167343__F1 Androgen metabolism scheme UGT2B17 UGT2B7 TG UGT2B15 PMC8686808__F2 Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection MPO APC CIC VWF TF PMC2617762__F6 Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia MAF KEAP1 PGAM5 PMC8306787__F4 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance LOXL2 PC HNF4A ATF4 CRTC2 PMC7847180__F8 Network analysis FCGR3A EGF TGFBR1 ARHA ARHGAP12 ARHGAP5 NECTIN2 AFDN PMC2866107__F5 Current Status of Xenotransplantation and Prospects for Clinical Application TFPI APC VWF TF PMC8120744__F4 Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health CXCR1 COX2 VEGFC VEGFA CCND1 IL8RB CD40 INSR PMC4211615__F1 EMT-associated signaling molecules in glioma cell EGF TNC HGF CXCR4 EGFR CD44 STAT3 PMC6994339__F1 Filtering through the role of NRF2 in kidney disease GCLM KEAP1 GCLC RBX1 NQO1 PMC6955051__F3 Role of interleukins in heart failure with reduced ejection fraction TH VCAM1 IRAK2 IL33 MYD88 PMC8236958__F6 Identification of Regulatory Functions of LncRNAs Associated With T. circumcincta Infection in Adult Sheep CD44 SRC RHO GAL PMC2736291__F2 Diagram shows the cell signaling pathways, which were involved in postconditioning BAD GSK3B PTEN PMC6681682__F2 Functional networks overrepresented in the list of DE mRNA in response to infection of bMDMs with Streptococcus agalactiae strain ST103 compared to uninfected controls EMILIN1 IL9 HEL-S-134P HUNK MYCBP NNT VASN AGO1 IGSF6 IFT74 PNKD ARL8B GIMAP4 C9orf72 NMI TM4SF1 GAL FMNL2 UNC119 TNRC6B PTTG1 ARHGDIB CEP170 AGO4 IGSF8 CEP97 NHSL2 SGSM1 CEP131 SPINT1 CACHD1 RAB19 B9D2 CNTRL SDCCAG8 PLCB2 HMMR GIG8 ARL1 IL23A ARL11 RP2 CETN3 TOX PAPSS1 MXI1 MICAL2 PMC11655346__F1 Unique role of DLL3 in the notch signaling pathway RBPJ ASCL1 ADAM10 DLL3 PMC8005123__F2 Molecular pathways of SMC-mediated migration and proliferation HES5 CX3CR1 GC HES1 HES2 PMC2924816__F1 Quantification of Beta-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry MMP7 CSNK2A1 APC GSK3B AXIN1 CD44 CCND1 AXIN2 PMC6826333__F1 Network of Beta-elemene-target genes P2RY11 KCNMA1 RAPSN MIP DRD1 HIF1A DRD2 HEL-S-5 KCNB2 MMP3 FYN APIP REST PALM RAPGEF2 APOE SNCA GNA13 GUK1 AMD1 CKMT1B PLCB1 KCNK18 SPTBN4 GLRA3 SAMTOR MTR GJC1 MAT1A IGF1 ACY3 KCNC1 KCNC4 SDF4 KCND1 KCND3 NR1C2 KCNJ10 NCMAP TNNI3K KLHL41 CRTC1 UGT3A2 LRRC4B CEP112 HPCA CNTNAP1 NETO1 LRRTM1 CNGA1 SCN3B RNF207 CNGB1 ZP4 DPP4 TSEN34 NLGN1 NLGN2 NRXN2 ACHE EIF2AK1 CLU FEN1 DIO1 SOX15 APP GNRH1 ADH1C HEL-S-117 IL10 STX7 USP2 LRRK2 OPRM1 SORCS3 CFTR HEL-S-4 CARD11 GIG8 MTRR HEL-S-1a GNAS OXT PPARG SIRT2 SLC24A1 UHMK1 TPO DSC2 ACSS2 CRLF1 RYR2 TSEN2 GPX7 PKLR PICALM SNX3 WLS KLHL17 DLG2 SLC18A1 TET2 CDK2 MC3R MEF2C HEL-S-62p ENTPD6 OLFM1 KCNA4 LDB1 GLRA1 ZP3 TRPM7 KCNE2 JUP CCND1 CDK4 MED1 UNC119 STAR FBP1 AUTS2 NTRK1 PTH ASPA KCNC3 CYP2E1 BGLAP UBQLN2 PINK1 GNAT2 ICMT CNTN2 INHA DAB2IP ARF6 NPY2R CKMT2 CHRNB2 GAD2 HAO1 EPO CASQ1 AHCYL2 PAX7 AQP8 CRHBP STX1A MAOA hCG_2044782 NRXN3 DLG4 CCNE1 GHR MPP3 HEL-S-44 SYT9 PRKAG3 TSEN15 PRKAB1 RELN KCNK4 AQP1 KCNA2 GLRB EDN1 LEP SNAPIN CRH KCND2 DAGLB HRC SYT7 ERCC1 CXCL12 MYOD1 CD36 HEL-S-182mP CASK GPX1 SHANK3 ADH7 DKFZp686L0365 EPB42 SCN2A IL18 PKP2 HEL-S-67p PPARGC1A DSG2 THBS1 ARX ALDH1A2 TRPA1 ARG1 SLC17A7 NPPA NFIB HEL-S-30 STXBP1 ARF1 ADH1A RS1 PRMT1 SLC4A10 FBXO32 ADA ATOH8 HCN2 BHMT2 PRKCZ DUOX1 ALDH3B1 DUOX2 APOC1 ALAS2 SHANK2 KCNC2 KCNK3 MTMR4 PAH CARF ACSS1 MRI1 ERMN ERCC5 SCN10A FOXE1 KCNK2 KCNAB1 FGA ChAT BMP6 RER1 SRPX2 CNGA3 DUOXA2 CACNG2 KLF4 PRKAG2 TNR CARTPT ATXN2 DAGLA MC1R KEL ERCC2 CIDEA SYP ALDH2 TH PRKCE HGF HEL2 PDE3A ATP1A1 PTEN MAGI3 FECH ENSA HMBS F2 CPOX PTPN11 CAV2 IL1B SLC24A3 GPHN ERAF CD14 MT3 KCNA3 SHANK1 MSTN NPTX1 KCNB1 PEMT HCN4 KCNA1 CANX MAP2K1 AHCYL1 AGER GJA1 ALDH1A3 OXTR CYGB HCN1 TRAF2 FADD HEL-S-20 INHBA HEL-S-29 LCT PMC6826333__F2 Network of pancreatic cancer-target genes PIK3R1 CD133 CCNA2 PLK1 ARHH KRT19 GRPR SMAD2 HSD11B1 MAPK14 SMAD4 CCL2 HIF1A FGFR2 IFNG MMP7 FLT1 KDR BCL10 CCL24 LPL SHH CASP9 SMO RAD51 SP1 ABCC8 ABCB1 IL1A ERBB3 APC IL1RN CTLA4 TNF GAD1 IRS1 CCKBR IGF1 CDKN1A TNFRSF1A STK11 BCL2 IL2RA TF TERT MUC1 AFP PGR TGFBR1 HMX1 RIT2 CCKAR MST1R MKI67 IL10 KIT DPYD ARHA RAC1 MUC2 DDIT3 CFTR HNF4A TFF2 ERBB2 TNFSF10 MUC6 TYMS GNAS PPARG OCIAD2 FHIT EPGN TNFSF6 FREP1 MIA PKLR MDM2 INSM1 SRC S100A4 ROS1 GHSR PLAUR CDKN1B VEGFA HFE MMRN1 HRAS NCAM1 CDKN1C RET CDK2 CXCR4 ENO2 MSLN CROP PDX1 BRAF CTRC SFN INS GCG ATM CCND1 GDNF CD55 CDK4 CDC2 JUN PTGS2 NTRK1 KRT7 PARP1 HMGA1 DCD MUSK PSEN1 ABCC1 MCL1 BIRC5 MYC F2RL1 ALOX5 RB1 PSCA SOX9 PI3 FGFR1 POMC BTC NR1i1 PC SSPN NOTCH1 HEL-S-44 MAPK1 NOS2 NT5E CASP8 AIP BAK1 GSTM1 LCN2 ENO1 HNF1A REG3A PTPRN IGFBP1 GH1 CXCL12 TGFA TGFB1 PCNA CD36 USP4 FOXM1 PSMD9 RRM1 SPINK1 MEN1 THBS1 IL4 KRT20 HEL-S-89n PRSS1 CALCA PDGFRA HEL-S-30 IGF2 NR3C2 CGA SCTR IAPP SSTR5 GHRL NFKBIA SKP2 SPARC HLA-E NGF WNT1 GCK FGFR4 BCL2L1 VIP COX5A APEX1 SLC2A2 KLK3 COX10 SERPINA1 HK2 PDAP1 FOS CD82 PTHLH BRCA1 LSM1 GLP1R MMP14 MUC4 HEL113 PSMD1 BDNF SYP CP HEL-S-7a EGF IGF1R BAD IFNA1 HGF EGFR PTEN BCL2L11 MTOR RIPK1 PLAT CRP PTPN11 IL2 ABCG2 CTNNBIP1 IL1B BAX HMGB1 EGR1 CD34 FGF2 CD44 IL6 ITGB1 CASP3 CCK MAP2K1 CDX2 NFKB1 PIK3CA RAF1 BNIP3 STAT3 PMC7096354__F4 Dysfunctional pathways of miR-15a and miR-24-1 RUNX1T1 KRT33B SFRP5 SIK1 PMC7074686__F1 Interplay of different signalling pathways that enable C OGT PMC8870141__F5 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models TH ChAT TNF PMC8201093__F2 Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer E2F4 E2F2 SPIN1 ATAD2 E2F3 PMC8870141__F2 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models CCR5 PDC CXCR4 IRF3 TLR3 PMC5916970__F1 NFKB/Rel and MAPK pathways activation TRADD TRAF1 TRAF3 TRAF2 STAT3 PMC5267440__F1 Molecular regulation of macroautophagy and targets for pharmacological stimulation of the autophagy-lysosomal pathway TSC2 ULK1 TFEB BCL2 PMC3048459__F3 TGFB Smad-dependent signaling pathway: TGFB exerts its effect by binding and activating type II receptor (TGFBR2) and then type I receptor (TGFBR1) SMURF2 TGFBR1 SMURF1 TF PMC5634336__F2 The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention EPO STAT4 TPO TYK2 JAK3 JAK1 STAT3 PMC6743726__F2 Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis HEL-S-61p PMC4905414__F1 Simplified model for phosphatidylserine receptor-mediated efferocytosis CD300LF SYK CD300A CD300LB PMC6480582__F7 Graphic summary for nifedipine-induced lipogenesis on renal tubular cell ACSL1 NR1C1 NDP HMGCR CD36 PMC11915795__F9 Proposed model for SVV antagonizes type I IFN signaling by targeting HDAC4 OAS1 IRF3 PMC5021219__F1 MOLECULAR PATHWAYS: JAK/STAT PATHWAY: MUTATIONS, INHIBITORS, AND RESISTANCE SOCS1 PMC6443324__F2 Modulatory mechanisms of TRAIL extrinsic signaling pathway by E3 ligases and deubiquitinases RIPK1 USP2 APAF1 MKRN1 TRAF2 FADD PAF1 ITCH BAX PMC6877906__F1 MyD88-dependent and TRIF-dependent TLR signaling pathways CD14 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 BTK TLR7 TLR4 TIRAP TAB3 CD36 PMC8107079__F9 CircPVT1 up‐regulation attenuates steroid‐induced osteonecrosis of the femoral head through regulating miR‐21‐5p‐mediated Smad7/TGFB signalling pathway CTSK BCL2 ACP5 COL1A1 BAX PMC6877906__F2 Proposed model for the role of TLR-mediated innate immune events in regulating the Th1/Th17 and Th2 immune balance TLR8 PDC TLR4 TLR3 MAVS PMC6940522__F5 Resveratrol downregulates miR-31 to promote T regulatory cells during prevention of TNBS-induced colitis SOCS3 LTBP1 SOCS1 PMC2713123__F6 Early- and late-phase platelet aggregation regulated through PAR1 PC HEL164 RHO LPP PMC10139073__F2 S1PR function in osteogenic cells COX2 S1PR2 RUNX2 S1PR1 S1PR3 SPHK1 RHO S1PR4 PMC10139073__F3 Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone COX2 S1PR2 GSK3B S1PR1 S1PR3 SPHK1 PMC8064175__F5 Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines IFIT3 C4B_2 IRF7 IFITM3 VSIG4 FITM2 C4A IFITM1 MX1 TYROBP C1QB C1QA CRP SERPING1 C1S C1QC IFIT1 PMC5998874__F3 Hypotheses of dysfunctional regulation mechanisms of gastric carcinogenesis around XBP1 CXCR4 ATF1 SRC GATA6 BCL2 CA9 MTOR XBP1 FKBP11 PPP1R1B STAT3 PMC8000263__F1 Ferroptosis signaling pathway GPX4 LPCAT3 FACL4 HEL-S-34 ADA POR PMC3408426__F10 Metabolic genes regulated by the Met TFs HEL-S-26 PGS1 PC ACO2 PMC10838060__F2 cGAS-STING pathway and the NFKB pathway TBK1 ULK1 ATM TRIM32 TRAF6 TRIM5 PMC8000263__F2 Lipid metabolic pathways that regulate ferroptosis GPX4 LPCAT3 FACL4 HEL-S-34 TNLG7C FADS2 ELOVL5 ADA FADS1 ELOVL2 ACSL3 GLA FASN CD36 PMC10838060__F3 cGAS-STING and JAK–STAT pathways TBK1 CGAS SOCS3 RNASE7 IRF3 TYK2 JAK1 SOCS1 USP18 PMC9208136__F1 Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli MVD MVK IPP PMC5017307__F1 Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy PDE4D KIF7 SUFU EVC2 PTCH1 GPR161 EVC SMO ADRBK1 INPP5E PMC2943291__F6 Proposed scheme of the molecular mechanism underlying LPCAT2 activation TLR4 MYD88 LPCAT2 PMC10838060__F1 Molecular mechanism of the cGAS-STING pathway TBK1 TLR4 TLR9 TRIM32 TRIM56 TRAF3 TRAF6 STIM1 IFI16 PMC3205057__F6 Influence of miR-300 on apoptosis pathway BAD TRADD FADD PMC3205057__F8 Effect of miRNAs on cell cycle, proliferation, and differentiation IFRD1 RUNX2 TP63 PXDN S1PR1 UGT8 MOV10 NR1C1 E2F3 AURKB CDK7 BNIP2 CCND2 CCNE1 TNFSF12 THBS1 JAK1 RAN INHBA RBL2 PMC5347721__F1 Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex TBP SRC SRY PMC6089764__F3 Interaction network of paeonol and known gastric cancer genes TGFBR2 CXCL8 SLC6A2 ESRRA STYK1 PGA5 DCN LCP2 NGFR DSG2 IL17A IL2 CASP8 IL1B M6PR PTGS2 LTB CASP10 PDK4 CFTR RTN4R CASP3 TSC1 ERBB2 VCAM1 TNFRSF1A TNFRSF10A CDH17 PMC6854620__F7 Running young is more effective than running at midlife MMP14 VEGFA NOTCH1 LAMB2 LAMA4 LAMA5 PMC3901350__F1 Noncoding RNAs in DNA Repair and Genome Integrity RNF168 RNF8 ATM MDC1 RAD50 PARP1 ATR H2AX MRE11A BRCA1 PMC6370266__F1 LPS-TLR4 activates the NFKB signaling pathway TLR4 TRAF6 MYD88 TNF IL1B PMC4317864__F5 Schematic representation of the mechanism for UCA1-regulated metabolic switch MTOR HK2 STAT3 PMC4048575__F5 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival MAF KEAP1 HEL-S-8a PMC7801696__F6 LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma ATM ATRIP EGFR RAD50 PMC4048575__F1 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival ATG12 ATG3 ATG101 UVRAG ATG10 DKFZp686F0183 PMC11053886__F2 Signaling related to flowering PRR9 ELF3 CRY2 ELF4 PRR7 PMC8201163__F1 Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications TLR4 ACACA GPX1 TNF IRS1 NR1C1 HMGCR FASN PMC9700203__F7 Chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood MYB PRX PMC5364265__F8 Putative transcription factor network for estrogen signaling E2F4 E2F7 SOX2 E2F6 FOXM1 TFAP2C PMC9353721__F4 Analysis of Protein–Protein Interactions Identifies NECTIN2 as a Target of N,N-Bis (5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis NLK FER FYN SMAD4 ARHA OTP LMO7 CDC42 INSR PMC7654589__F2 Canonical PINK1/PARKIN pathway PINK1 VCP PARL PMC4012261__F6 Graphical representation of the genomic neighborhoods of SRF and ZNF350 SPARC FLNA ACTA2 DES PTEN PARVA ZNF367 S100A6 CCNE1 ZNF350 ACADS ATM KCNN2 EPPK1 LPP NCOA1 DCXR RASSF2 SP1 PRRX1 HEL-S-28 SPEG TAGLN PLAGL1 SMPD1 SAMD11 PLEK ATR LAMC1 PXN RASAL1 PMC3094296__F1 KEGG pathways used for the influence approach TBK1 CXCL1 MHC2TA CXCL5 CXCL10 TRAF3 CXCL3 CXCL2 IRF3 IL6 RAC1 TLR1 TLR3 STAT1 CXCR3 CXCL9 CXCL6 B2M IL1B CXCL11 PMC7375892__F5 Affected Local Networks by RB1 and TP53 Inactivation Events ASF1B NCOR1 PLK1 CHAF1B FANCD2 RB1 TFDP1 PRIM1 CDKN2A CCNE1 POLE POLA1 INPP5D MSH6 MDM2 NOTCH1 SRC HDAC2 RAD51 EZH2 MSH2 RPL3 CENPA HSPA4 DDB2 DSCC1 BRCA1 CDCA8 AURKB CALM1 MCM3 CDC20 MCM6 MCM2 CDKN1A HEL25 CDK2 STK4 CCNG1 CDT1 PCNA BLM CDKN2C EGFR GPS2 DNMT3B FEN1 BTK RPL11 NUF2 PRC1 KNTC2 CCNB1 CCND1 RPL26 CDC2 PTPN6 GMNN CCNE2 MYBL2 RPA1 CHEK1 HDAC1 AURKA RFC4 PTPRC RFC2 BUB1B TUBG1 LCK ZAP70 HAUS1 SYK ZWINT USP1 PMC4868692__F8 Triptolide induces protective autophagy through activation of the CaMKKBeta-AMPK signaling pathway in prostate cancer cells TSC2 ULK1 MTOR DKFZp686F0183 HEL-S-29 PMC6694711__F2 Renin-angiotensin system and its bypass loops and converging signaling pathways can be targeted at different points COX2 PMC7310559__F8 CYT997-induced apoptosis in GC cells CCND1 STAT3 PMC10495336__F6 Working model of the oncogenic potential of SGG UCN34 PDGFRA HEL-S-28 CD34 EGFR PDPN MTOR PMC3132641__F3 Proposed mechanisms mediating the effect of the (pro)renin receptor (PRR) in metanephric kidney development RET EGFR LRP5 SELL PMC6738049__F1 Illustration summarising the major tumour procoagulant effects in pancreatic cancer TFPI PDPN HPSE TF PMC6738049__F2 Haemostasis and fibrinolysis TFPI PLG PSCA TF PMC8833084__F5 Combined Proteomic and Metabolomic Strategy for Allergens Characterization in Natural and Fermented Brassica napus Bee Pollen FBP2 GHB2 FBP1 PMC10383317__F3 Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children GHSR NPY AgRP LEPR SIM1 SH2B1 BDNF NTRK2 PMC7674197__F1 TLR signaling and the endogenous DAMP pathway in systemic JIA and AOSD NLRP3 HMGB1 TLR7 TLR4 IRAK1 IRAK2 S100A8 TRAF6 IRAK4 S100A9 MYD88 IL1B PMC8636938__F2 Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries AHR MTOR PMC7522371__F4 TGFB signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 PMC6803483__F1 Metabolic pathway of linoleic and arachidonic acid LTA LTB LPA PMC5520901__F8 UCNPs-Ce6-mediated PDT and the mechanism of autophagy.Notes: UCNPs-Ce6-mediated PDT exhibits an autophagic response through the PI3K/Akt/mTOR signaling pathway that is regulated by ROS, which causes the ABCA1-dependent cholesterol efflux ABCA1 MTOR PMC3603396__F3 Altered colonic metabolites during conventionalisation TH PGAP1 HAL GDA ASNS FARS2 GAL CAD RAN SELE PMC6678174__F1 Mitophagy pathways PINK1 ARIH1 FUNDC1 BNIP3 OPTN PMC2929604__F1 Role of TLR4 in hepatic I/R injury HMGB1 TLR4 CXCL10 IRF3 MYD88 IRF-1 MAL PMC9704080__F8 13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3K/AKT/mTOR/p70S6K signalling pathway BAD MTOR BAX PMC3064322__F5 Model showing the regulation of PPARA by metabolism and PAR bZip transcription factors LPL NR1C1 FASN PMC8825381__F1 Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations PC MYC PTEN ACLY ASS1 HEL-S-133P ASL HEL-S-281 GLS PMC5482641__F3 Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder COL18A1 CTSS IRF7 CEBPA UNG ST14 IFITM1 CGB8 HEL57 HPGD PRSS2 KYNU STEAP1 CFD GJB3 DNASE2 SMAD1 CP DKFZp781O1323 COL4A1 PMC2790273__F1 Possible cross-talk between Nod2, TCR, Cd28, TLR and TNFR family members in regulating NFKB RELA TRAF3 RELB TRAF6 MYD88 MAP3K7IP1 TRAF2 NOD2 TAB3 PMC12068849__F1 Canonical and non-canonical signaling pathways NLK APC GSK3B LRP5 LRP6 ARHA RAC1 CDC42 PMC12068849__F2 Wnt/Beta-catenin pathway activation and inhibition APC LRP5 ADA LRP6 PMC12068849__F3 Wnt signaling within the breast cancer TME NUMB RUNX2 DKK3 VEGFA RYK DKK1 CCL2 HIF1A SOX4 CD81 FOXP3 NRP1 CD163 DVL2 BCL9 TCF4 CD68 ABCD2 PMC5437112__F1 Illustration of autocrine and paracrine signaling pathways in colorectal cancer BRAF APC SHH RBP2 LRP6 SMO EZH2 AXIN2 TNKS2 PMC10777970__F7 Hedgehog (Hh) signaling pathway SUFU PTCH1 SMO PMC4747347__F2 Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose PINK1 ULK1 ATG12 ATG3 ULK2 ATG10 MTOR DKFZp686F0183 PMC5932548__F4 miRNAs in renal fibrosis SMAD4 PMC5932548__F3 Signalling pathways initiated by miRNAs and TGFB in diabetic nephropathy PAK1 COL1A2 PTEN PMC2254980__F3 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice CPT2 ELOVL6 LPA TG PMC2254980__F4 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice ELOVL6 TG PMC6442448__F2 Target-pathway network CCNA2 PDE3A EGFR GSK3B PTGER3 CCL2 MTOR PTGS1 INSR IFNG MMP3 KDR CD40LG CHRM2 NOS2 SELE IL10 PTGS2 MMP9 VEGFA ADRB2 TNF GRIA2 NR1C1 RXRA CASP3 ADRA2A RELA NR1C2 HTR2A NCF1 PPARG PMC10037992__F4 Fasting: From Physiology to Pathology PDX1 PAX7 NEUROD1 MTOR PMC6442448__F1 Compound-target network F10 CCNA2 MPO THBD PDE3A EGFR DPP4 GSK3B PTGER3 CCL2 INSR IFNG MMP3 PRKCA PLAT MMP2 F3 CRP CD40LG ABCG2 CHRM2 NOS2 IL4 SELE IL10 PTGS2 MMP9 VEGFA PTGES ADRB2 IL6 TNF GRIA2 NR1C1 RXRA ADRA2A RELA NR1C2 F7 BCL2 HTR2A SCN5A PMC8993538__F12 Optophysiology: Illuminating cell physiology with optogenetics YAP1 CRY2 EGFR STAT3 BAX PMC1450137__F4 Proposed mechanisms underlying the control of Mesp2 expression RBPJ TBX6 MESP2 PMC12027300__F2 Influenza viral suppression of the host immune response by upregulating cellular proteins HLA-E HLA-G RUNX1 SOCS3 STAT2 IRF7 EGFR IRF3 IFNAR2 IFNAR1 SPHK2 HDAC1 HLA-B HLA-C IFNLR1 STAT1 ERAP1 TET3 TYK2 JAK1 MAVS SOCS1 PMC12027300__F4 Upregulation of cellular proteins that control influenza viral pathogenicity TLR4 CXCR4 MYD88 SP1 OSM WNK4 CTHRC1 PMC5369369__F55 Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/Beta-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease KEAP1 IMPACT APC LRP5 LRP6 PMC8387187__F8 Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis CD14 SOCS3 STAT3 PMC3167888__F6 Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages ATM APAF1 BCL2 BAX PMC8509806__F6 Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights CDK4 PTEN BAX PMC5085687__F5 Molecular mechanisms of osteoporosis in ACTH-secreting pituitary adenomas ANGPT1 HTRA1 CRH NFATC1 opn GRB2 UNK JUN PMC11943880__F2 Physiological effects of KYN pathway metabolites TBK1 CGAS AHR CDX2 STC2 IRF3 MUC2 PMC8139196__F2 Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients TBK1 NLRP3 ULK1 DISC1 SIRT6 PARP1 SIRT1 SIRT3 PMC2727567__F1 Unwelcome Complement HEL-S-62p MASP1 FH MASP2 C4A PMC7070965__F7 EDG and DC on FcERI-mediated signaling pathway in KU812F cells LYN SYK LAT PMC11943880__F1 Kynurenine pathway HAAO HEL-S-90n KYNU KMO AFMID PMC12068849__F4 Interaction between the Wnt signaling pathway and other pathways in the breast cancer TME KIF7 FOXF2 SMAD2 APC GSK3B LRP5 SMAD4 LRP6 FGF18 MTOR FGF20 FOXF1 WNT3A WNT4 FRS2 FGF3 SUFU GRB2 SHH SFRP1 SMO WNT2B WNT7B PMC4175047__F9 Proposed mechanisms by which miR-34a regulates mesangial cell proliferation CDK2 CCND1 CDK4 CDK6 PMC6737211__F5 Activation of Ser/Gly synthesis from glucose, their efficient incorporation into purines, and reverse flux of the Ser–Gly one-carbon pathway underlie preference for glucose as substrate for purine synthesis in lung cancer tissues ex vivo MTHFD2L CD2 SHMT1 MTHFD1 GLDC HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC5623591__F3 Central tolerance for B cells MYC PLCG2 PTEN CD79B FOXO1 CD79A INSR BTK BCR BASH HEL-S-11 GRB2 SYK RAF1 STIM1 CD19 PMC4891409__F1 MiRs and their targets in signaling pathway of LSCC PLK2 RUNX3 IGF1R HGF FOXM1 IRF9 SMAD2 TGFBR1 APC PDK2 SMAD4 PTEN HDAC1 STAT1 GALNT7 MAX CASP9 CCND1 JAK1 SIRT1 SKP2 STAT3 PMC8214167__F6 Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors TBK1 STAT2 IRF7 IRAK1 IRAK4 IRF3 IFNAR2 MYD88 TNF PELI1 IFNAR1 TLR3 STAT1 NLRP3 TLR8 TLR7 ITPKC IFI16 STAT3 PMC8945019__F5 Immunosuppressive Signaling Pathways as Targeted Cancer Therapies SUFU PTCH1 GLI3 SHH SMO PMC4673190__F1 The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer ATM MDM2 ATR BAX PMC6981480__F1 ER-stress induced UPR signaling ATF4 EIF2A PMC3135180__F3 Convergent stem cell regulatory networks control expression of key stem cell genes LEF1 SOX2 PMC3234195__F1 Petroleum diesel, biodiesel, and ethanol PC DES LPA PMC10745821__F9 Proposed model of the signaling pathway induced by the CSHE treatment FOXO1 ACOX1 FASN PMC8599200__F6 Normal and Premature Adrenarche AKR1C1 AKR1C4 POR AKR1C2 PMC8715300__F12 Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome MMP12 CXCL10 DUOX1 DSC3 PMC10578286__F1 Insulin signaling pathway schematic INS PTEN IRS1 PMC4872805__F2 Sirtuins as regulators of metabolism and healthspan NCOR1 NRF1 NDUFA9 CRTC2 NR1C1 SIRT1 FOXO1 UCP2 SIRT3 PMC4872805__F3 Sirtuins as regulators of metabolism and healthspan SIRT2 HNF4A SIRT4 SIRT6 CRTC2 HIF1A SIRT1 FOXO1 UCP2 SIRT3 PMC11395051__F7 The results and the proposed mechanisms of action of the examined proteins and signaling pathways in HEC-1A cells EGF TIMP1 CX3CR1 MMP2 BMP2 LIF MMP9 EGFR IL6 SOX17 STAT3 PMC4872805__F1 Sirtuins as regulators of metabolism and healthspan NCOR1 PARP2 CDC2 NR1C1 SIRT1 FOXO1 HIC1 PMC2739389__F2 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape IGF1R HGF BRAF IGF2 MAPK3 PTEN MTOR FOXO1 CDK6 IGF1 CCND1 CDK4 MAPK1 PMC4765871__F8 Refined subnetwork using reconstructed pseudo time-series data (left) compared with experimental validated network in () (right) NFE2 GFI1 GFI1B GATA2 PMC3632131__F1 Shared network structure by non-small lung cancer pathway in KEGG and reconstructed co-expression networks using the CCA and GLASSO methods PIK3R1 EGF BAD FOXO3A SOS2 NRAS MAP2K2 PLCG2 RB1 HRAS PIK3R3 E2F3 PRKCA PIK3R5 PRKCB RASSF1 E2F2 GRB2 CASP9 CCND1 SOS1 TGFA ARAF AKT3 PMC3323563__F8 Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2 APAF1 CDK2 PMC7279704__F1 Simplified representation of mechanisms of DDR and DNA repair XRCC5 PALB2 IGF1 BRCA2 SSB XPC RAD51 ATR OGG1 BRCA1 TERT CPD PMC3438135__F1 Altered pancreatic beta cell mechanism silencing alpha and delta cells TH PI3 CRH HEL-S-11 MAPDA PMC6416708__F1 Triglyceride-rich lipoprotein metabolism and mechanism of atherosclerosis ANGPTL3 ANGPTL4 LPL LDLR PMC2739389__F3 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape CASP3 BAD APAF1 CASP9 BCL2 CAD CASP8 FADD BAX PMC9169370__F2 Pyroptosis in inflammatory diseases and cancer CASP6 NLRC4 NLRP1 RIPK3 TNF ZBP1 GSDMD NLRP3 RIPK1 GZMA GSDMC CASP8 AIM2 FADD GSDMB DFNA5 PMC10987323__F7 MtETC in regulating bacterial infection IL10 HEL-S-62p NLRP3 PMC8116547__F1 miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection LTA COX1 LCK LTB PMC6749033__F2 Metabolic regulation of pleotropic autophagy NPRL2 ULK1 LCMT1 NNMT PMC10987323__F9 MtETC in M1 macrophage polarization RET CIC ACLY PMC7204879__F4 HCoV-host interaction PLP2 ATF4 EIF2A BCL2 BAX PMC10151377__F3 Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases ADM PMC7654518__F3 Molecular mechanisms of SGLT2 inhibitors on iron homeostasis, mitochondrial function, and cardiac microvasculature in diabetic cardiomyopathy MFN1 MFN2 TFAM FIS1 PMC9467784__F2 Targeting Strategies for Aberrant Lipid Metabolism Reprogramming and the Immune Microenvironment in Esophageal Cancer: A Review HEL-S-62p TLR4 EP300 APC EGFR ACSS2 MTOR FASN STAT3 PMC5706744__F1 Mammalian biogenic polyamines and metabolic pathways OAZ1 SRM EIF5A PAOX DOHH SMO DHPS SMS PMC4307161__F16 The Therapeutic Potential of Cystathionine Beta-Synthetase/Hydrogen Sulfide Inhibition in Cancer GOT2 PMC3250173__F7 TLR3/TLR4-mediated signaling pathways TLR4 IRF3 MYD88 TLR3 TIRAP MAL PMC6844216__F1 Different death mechanisms of liver cells are involved in the pathogenesis of liver injury induced by MNPs TRADD MTOR GSDMD PMC12207208__F3 TREM2 activation and downstream signaling TREM2 binds to ligands such as AB, ApoE, HDL, and LDL, leading to its activation SYK TYROBP PMC6510993__F8 Model of GQ folding within the actively extending telomerase complex TPP1 TERT PMC5595712__F3 A maize amino acids network involving key genes identified in this study by GWAS IVD GAL NNAT PMC5559637__F5 H. pylori cag-T4SS-dependent, NFKB-driven innate immune response in gastric epithelial cells NOD1 TIFA TRAF6 ALPK1 PMC6480367__F1 Rapamycin (mTOR) signaling pathway TSC2 TTI1 TSC1 GRB2 PTEN DEPTOR RHEB PMC2561962__F1 Ischemia induces cell death by several distinct pathways, and Hsp70 reduces all of these APAF1 CASP9 BAX PMC2775177__F1 Branches of the UPR signalling pathway ATF4 EIF2A XBP1 PMC11012680__F2 Synthetic Routes and Clinical Application of Representative Small-Molecule EGFR Inhibitors for Cancer Therapy EGFR GRB2 SRC PMC5301276__F2 Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases PTEN INPP4B AKT3 PMC8906189__F4 The Coagulation Pathways Leading to the Formation of D-Dimer During Blood-Brain Barrier Disruption PLG FDPS APC PMC10838060__F10 CGAS-STING by metal ions FEN1 NLRP3 CGAS STIM1 PMC7838386__F3 Extracellular factors govern dendritic morphogenesis via convergent signaling TSC2 TSC1 SMAD2 LECT2 RHEB PMC8883286__F3 Mechanisms Underlying Influence of Bioelectricity in Development CDK2 CDK4 CDC2 CDK6 PMC5420432__F1 mTOR signaling pathway in podocyte autophagy TSC1 PKD1 MTOR PMC8600424__F1 New insights into Epstein-Barr virus-associated tumors: Exosomes TSG101 CD63 TRAF2 PMC7827772__F3 Calreticulin (CRT) exposure in the response to immunogenic cell death (ICD) inducers SNAP23 BAX PMC11397228__F4 Impact of BPs on metabolic disease treatment via gut microbiota modulation TLR4 FGF19 PYY MYD88 TG FASN PMC5527946__F1 Regulation of autophagy TSC2 TSC1 GRB2 BCL2 UVRAG RHEB PMC1854955__F7 Schematic depiction of the molecular mechanism for the progression from HPS to chronic active disease or T-cell lymphoma in EBV-infected T cells TRADD TRAF5 TRAF2 FADD PMC5310163__F7 Interaction of lactobacilli with transformed cells MPO LPO PMC6306440__F1 Abnormalities in the DNA damage repair pathway in T cells of rheumatoid arthritis patients ATM ATR MRE11A PMC7442613__F1 Topical treatment strategies to manipulate human skin pigmentation POMC DCT TYRP1 MC1R PMC5932357__F2 Antimicrobial autophagy is inhibited in Mycobacterium leprae infections through the activation of the type I interferon (IFN) pathway TBK1 ESX1 OASL CGAS IRF3 PMC8995529__F5 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway CDKN1B RB1 MTOR CDKN2A CDK6 CASP3 BIRC2 CDKN1A CDK2 BIRC3 CYC1 CCND1 CDK4 PCNA PMC6966636__F9 HMGCS2-mediated ketogenesis impacts liver cancer progression and treatment CCND1 CDH2 BAX PMC8995529__F1 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway CDKN1B RB1 CDKN2A CYP1A2 CDK6 CASP3 BIRC2 CYP2C9 CDKN1A CYP2C19 CDK2 BIRC3 CCND1 CDK4 CYP1A1 PCNA PMC7179138__F5 Schematic diagram illustrating the mechanisms of A BAD TRADD FADD BAX PMC4393010__F12 Pathway regulation by CsrA CS GIP CIT HEL107 RPE MAL HEL-S-162eP PMC7998903__F5 Involvements of the studied neurotransmitters in tumor development EGR1 RAP1GAP2 ADRA1D DRD2 MTOR PMC3205804__F2 From a physiological point of view, exfoliated epithelial cells resulting from nutritional induction or mild stress are in anoikis by activating a survival mechanism partly using the molecular paths of macroautophagy IMPACT MTOR IRS1 RHEB PMC6966539__F2 p53 control of cellular metabolism TIGAR SCO2 F2 PDK2 PMC4014913__F2 Metabolic pathways of fatty acid (FA) and triacylglycerol (TAG) synthesis, and mechanisms by which lipid intermediates affect hepatic insulin sensitivity ELOVL6 LPA MTOR IRS1 PMC6966539__F3 Dual effect of p53 on autophagy PINK1 ULK1 MTOR PMC10604560__F3 Lipid metabolism ELOVL6 LPA ACLY TNF TG NR1C1 FASN CD36 PMC4726449__F5 Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers TSC2 MCM6 HEL-S-11 HBD CA3 SCRIB B2M MAL PMC8868324__F7 Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway GPX4 GIP PMC5440785__F2 Schematic representation of the contribution of ER stress to the development of atherosclerosis
protein 1 ATF4 EIF2A XBP1 PMC6589170__F1 NLRP3 inflammasome pathway NLRP3 IL16 TLR4 MYD88 PMC8035014__F8 Immune regulatory activity of TCM formula ZQT in TME GMDS IFNG STAT3 PMC4026543__F2 EPH receptors crosstalk with EMT-related signaling pathways RAC1 EPHA2 EPHB4 EPHB3 PMC8684645__F2 NK cell upraise in the dark world of cancer stem cells IL15 CD34 KLRG1 TNF IFNG PMC6126141__F1 Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy ME1 EGR2 JMJD5 KDM3A SHH RBP2 GDNF HDAC2 KDM4C SOX10 KDM6B PMC9034918__F6 Screening Potential Drugs for the Development of NAFLD Based on Drug Perturbation Gene Set APP PMC7862630__F3 Deubiquitylases in developmental ubiquitin signaling and congenital diseases USP4 USP26 USP15 USP21 SMAD4 USP16 USP9X USP44 USP22 OTUD5 MYSM1 USP1 BAP1 PMC9550461__F4 Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases EGFR SRC NOX4 RAMP1 STAT3 PMC5285405__F3 Viruses exploit host proteasome pathway for immune evasion PML IRF7 RELA RAD50 IRF3 MYD88 MRE11A SP100 IFI16 MAL PMC8324245__F7 Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal Nematode Haemonchus contortus—A Novel Report CD14 TLR5 CTSK TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TNF TLR3 LBP CD40 FADD TIRAP PMC5285405__F5 Viral regulation of host proteins via post translational modifications PML HDAC3 IFRD1 RELA EGFR IRF3 PMC9256444__F6 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting SMAD2 SMAD4 PTEN MTOR PMC9256444__F5 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting APC GSK3B LRP5 LRP6 SMO PMC8469761__F1 Glycosylation in Vascular Calcification FGF23 RUNX2 BMP2 MTOR SMAD1 DKFZp781O1323 PMC9256444__F2 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting MMP3 TNC HGF MMP2 MSC MMP9 VEGFA CXCL12 TGFA PMC12166595__F2 The Notch signalling pathway and conservation of its components across metazoan lineages NUMB ATXN1L ADAM10 FURIN HDAC1 NEDD4 PMC8511326__F4 Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch GGH CRISP3 UTS2R PHKA1 CXCR6 PYGM PPP1R3A XCL1 FGF3 TMOD1 IL8RB RPTN NTSR1 CSTA EDNRB PHKB HEL-S-273 HRC ADRA1A TGM1 TPM1 DES ASB10 FGF23 MMP27 NIPAL4 ASB14 ZBTB16 CERS3 ASB18 ASB16 FBXO40 TNNT3 NPBWR1 FGF22 KRT1 NTSR2 ASB4 UBE2D1 NOTUM CXCL2 CASP14 TRAIP DMP1 IGFBP5 CHRM3 TRIM63 ASB2 LIPN PMC6561926__F9 Schematic depiction of lncRNA-p21/EZH2/STAT3 pathway STAT3 PMC8801635__F12 Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway ALB STAT3 BAX PMC2697619__F5 Proposed signaling pathways by which the Tec kinases regulate JNK activation, actin polymerization, and cytokine expression in LPS-stimulated neutrophils CD14 TLR4 LBP TEC SYK IL1B CDC42 PMC6982012__F2 Conversion into myofibroblasts from quiescent fibroblast involves mechanical and paracrine activation of profibrotic pathways SMAD2 SMAD4 PMC3342643__F3 Diacylglycerol kinases in immune cell function and self-tolerance PLCG1 BCL10 PMC6337644__F3 Telomeres are cap-like features at the ends of chromosomes that help protect them when cells divide CS AACS PMC7472989__F1 Classical neuroimmune network GC IL1B IFNG PMC8764250__F3 Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil? STAT1 TYK2 JAK1 GATA3 PMC7653026__F3 NFKB inflammation signaling pathway diagram TLR5 TLR4 TRAF6 MYD88 TLR1 PMC9359100__F7 Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication NLRP3 MFN2 IRF7 PMC7246618__F1 Monoubiquitination in human diseases FANCD2 EGFR HLTF FANCL PCNA ITCH USP1 UBE2A CBL PMC11241178__F8 Target pathway analysis of cordycepin combined with doxorubicin against breast cancer CASP3 MMP3 CXCL1 TRADD NFKB1 MMP9 MAP3K7 CCL2 JUNB TNF CASP8 ITCH PMC8584933__F1 Genome-Wide Analysis of Alternative Splicing and Non-Coding RNAs Reveal Complicated Transcriptional Regulation in Cannabis sativa L. IPP PMC2937452__F1 Model of pyrimidine synthesis and salvage pathways in Toxoplasma gondii UPRT OMP DHODH PMC10761042__F8 PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway CDK3 CDC2 CCNE1 PMC10506040__F2 Schematic representation showing downstream signaling events in cross-talk between adiponectin signal transduction and insulin signaling pathway[67] ADIPOR1 ADIPOR2 PTEN IRS1 APPL1 PMC12091695__F1 Simplified schematic representation of steps linking dyslipidemia with macrophage/microglia induced RNV TREM1 ACAT1 LDLR IL6 TNF HEL-S-5 PMC6953124__F9 Proposed anti-tumor mechanism of rubioncolin C TRAF6 MYD88 MTOR MAP3K7IP1 TRAF2 PMC5677515__F3 Significantly Mutated Genes and Regulatory Pathways in SCLC – A Meta-analysis BOC RAD1 SEMA7A HEL-S-28 FES RRAS RYK ARHA ROBO2 RHOD ROBO3 FYN PTCH1 SIT1 SHH ROBO1 SMO NEK1 PMC8802069__F9 Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin NLRP3 SPN MTOR PMC3725781__F1 Genetic and molecular control of Osterix in skeletal formation IGF1 RUNX2 BMP2 COL1A1 XBP1 SOX9 PMC3642687__F1 Pathway of reversible protein modification reactions that involve NAD+ consumption MACROD1 MACROD2 PARG PMC3437319__F2 Regulation of mammalian target of rapamycin complex (mTORC) signaling networks TSC2 TSC1 EIF4E IRS1 RHEB PMC5618627__F3 HSP40 family member, DNAJB6a (MRJ), prevents tumor formation through inhibition of the Wnt pathway WNT3A DNAJB6 APC WNT1 GSK3B LRP5 MSX1 LRP6 DKK1 PMC5618627__F2 HSP27 mediated suppression of apoptosis promotes tumorigenesis MAPKAPK2 MAPKAPK3 PMC7403357__F3 Bioinformatics analysis of data PML F10 APLN ADAM12 RNF213 S1PR5 MYL7 SP100 PROK2 SELL ECT2 SEMA4D ZBTB16 CSF2 MDK LGALS9B NELL1 KIT ITGB3 CXCL10 AIF1 OLFM4 HS6ST2 IL18BP FERMT3 NDP ITGAM PRKCB IGF1 PIM3 RGCC TWIST1 SYK CR2 SRGN PMC7987459__F2 Molecular pathways affected by Mn porphyrins in normal and cancer cell EIF5B GCLM CTSS KEAP1 SMAD2 MAPK14 SMAD4 NOX4 HEL-S-21 DKFZp686F0183 HEL-S-22 GRB2 PRX UCP3 PMC7881125__F6 Distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma CTH MTR SRM HEL-S-51e EZH2 AMD1 PMC9576726__F7 Effects of MSC-Exos on glycolysis and renal fibrosis MSC TEC PFKM PMC11222861__F8 Brief proposal model of altered epigenetic regulation mechanisms of histone H3K27 acetylation causing FLHS and a summarized workflow of comparative analysis of fatty liver disease among different species MAMDC2 KIT APOA4 PCK1 NTRK2 INHBE PMC4150259__F1 An overview of oncogenic KRAS-driven RAF/MEK/ERK and PI3K/PDK1/AKT signalling networks in pancreatic cancer EGF EGFR PTEN MTOR PMC4402634__F3 KEGG pathway map for TGFB and MAPK signaling pathways DAO MAX NODAL FRK UST SKP1 PMC7501485__F7 Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways ATF4 BCL2 BAX PMC4402634__F4 KEGG pathway map for complement and coagulation pathway HEL-S-62p F10 PROS1 F2R CS THBD F8 F9 PROC PLAT C9 A2M F2 F3 C7 VWF F11 TFPI PLAUR PLG KLKB1 CPB2 C6 F7 CR2 SERPINF2 PMC6838686__F2 Systemic Immune Dyshomeostasis Model and Pathways in Alzheimer’s Disease ChAT CCR2 IL18 PC NGF GSK3B IL6 BDNF APOE PEMT PMC9078761__F7 Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease BACE1 SNCA VAPB LRRK2 ATXN3 HTRA2 PDYN CASP9 TRPC3 ATXN2 VCP CASP8 BAX PMC8064375__F4 Persulfidated proteins identified in root tissues involved in autophagy ATG12 ATG3 ATG10 PMC3646067__F1 Proposed scheme linking metabolic and signaling pathways to insulin resistance in the heart TRO MTOR TG IRS1 CD36 HEL-S-5 PMC3512574__F5 TGFB in Cancer E2F4 CDK2 MYC SMAD4 FOXG1 ATF3 CDK4 ID1 SMAD1 PMC6360516__F7 LIMK2-Mediated Cofilin1 Phosphorylation Signals TGFB1-Induced GC InsensitivityPhospho-cofilin1 is implicated as a key link in the chain of signalling behavior of TGFB1-induced GC insensitivity LIMK2 LPA CDC42 PMC12248293__F9 BRD4770 attenuating DOX-induced cardiac injury through the Nrf2/ATF4/SLC7A11 pathway GPX4 SLC7A11 ATF4 PMC6549480__F7 A schematic molecular model for PSMD3 in the stabilization of HER2 USP14 PSMD3 PMC5594516__F9 Schematic representation of the proposed mechanism of circLARP4 in GC cells AGO2 GC LATS1 PMC3512574__F3 TGFB in Cancer GDF6 GDF5 LIMK1 gdf7 LEFTY1 NODAL CRIPTO BMP2 LEFTY2 AMHR2 TRAF6 RHO BMP4 TGFBI ACTR2 CDC42 PMC8258161__F1 Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis WIZ DAP GAL EMP1 MAL PMC6134143__F5 TNFR2-triggered, necrostatin-1-sensitive TNFR1 signaling RIPK1 TRAF1 RIPK3 TNF TRAF2 CASP8 IL1B MLKL PMC5233421__F6 Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability VCAM1 PECAM1 SERPINE2 PMC1665458__F7 Proteins differentially regulated in RCC involved in carbohydrate metabolism are shown overlaid on the glycolysis and gluconeogenesis pathway KEGG #00010 diagram HEL-S-165mP SUCLG1 ENO2 HEL-S-87p PCK2 ECHS1 HEL-S-133P PMC11173325__F1 The mTOR signaling pathway and the cellular functions driven by the formation of its two main complexes, mTORC1 and mTORC2 TSC2 TTI1 TSC1 PTEN DEPTOR IRS1 SGK1 RHEB PMC11173325__F2 Roles of mTORC1 and mTORC2 in regulating metabolic diseases, cancer, and aging PTEN FURIN EIF4E TG IRS1 NLRC3 PMC7082927__F1 Molecular pathogenesis of thyroid cancer involves dysregulation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways BRAF PTEN PPARG TERT PAX8 PMC8097461__F6 Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin FOS EIF5A CIT IPP MAL PMC7082274__F1 Steroidogenic pathway for aldosterone and the ‘hybrid steroids’—18OH-cortisol and 18-oxocortisol CYP11A1 HSD3B2 CYP17A1 CYP21A2 STAR CYP11B2 PMC4629494__F1 Pyruvate and octanoate metabolism in the liver CS PC CIT PMC7017171__F1 Phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway PCK1 MTOR PMC4023029__F7 Proposed pathway for activation/proliferation of alloantigen-specific nTreg and comparison with the non-antigen driven proliferation of nTreg that do not have a TCR specific for the antigen IL5RA FOXP3 PMC4775314__F3 Untapped Potential of Tyrosine-based G Protein Signaling TLR4 SI STAT3 PMC8443980__F1 Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases NLRP3 PINK1 ATG12 UCP1 DKFZp686F0183 PMC8122529__F2 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process GCLM KEAP1 RBX1 PMC8122529__F3 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process GCLM KEAP1 RBX1 PMC3319771__F2 Convergence of miR-21 target genes and the apoptosis pathway BAD TRADD TP63 TGFBR2 SPRY1 PTEN TNF PELI1 NR1C1 SPRY2 APAF1 MSH6 DAP3 MSH2 FADD BAX PMC7797171__F5 Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells CCNB1 SRC SP1 PMC6323245__F1 Different stages of erythropoiesis and regulatory processes (including cytokines, transcription factors and related signal transduction proteins) EPOR NFE2 IGF1R EPO IGF1 LYN tal-1 GFI1B GATA2 GATA1 PMC6323245__F2 PI3K/Akt signaling pathway and glucose metabolism (glycolysis, glucose uptake, nitric oxide glucose synthase, apoptosis and cell survival) EGF BAD PDK2 EGFR PTEN MTOR PMC4593336__F1 Canonical Wnt3a pathway MARCKS WNT3A SULF2 FOXM1 APC LRP5 CD44 LRP6 ROR2 PMC7173926__F5 Computational analysis for identification of the extracellular matrix molecules involved in endometrial cancer progression COL28A1 COL26A1 ITGB3 COL23A1 ITGA2B COL19A1 COL27A1 PLCG2 COL22A1 ARHG BTK FYN COL12A1 LYN CRP COL13A1 ADAM10 COL24A1 COL2A1 SCHIP1 LAT COL25A1 COL10A1 COL4A1 PMC3991963__F1 TGFB2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma FST LOXL2 BMP1 LOXL3 LOXL4 THBS1 LTBP1 SMAD1 DKFZp781O1323 BMP4 PMC7137995__F5 Elucidation of Functional Roles of Sialic Acids in Cancer Migration GM2A GLB1 NEU1 ST8SIA5 B4GALNT1 GAL ST3GAL1 ST8SIA1 B3GALT4 ST3GAL5 PMC4898408__F3 Hub-pathway network of GSZD CHUK LTA FCGR2A PROC NR3C1 FLG PARP1 TNF PPARG JUN PMC3572738__F4 Cellular iron balance ALAS2 SKP1 FBXL5 PMC8120506__F2 Mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review) NRF1 TFAM SIRT1 PMC9588203__F1 Triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases COX2 HEL-S-11 ZAP70 SYK PMC8198060__F2 Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer FANCD2 SLX4 UBE2T FANCL FANCA FANCB BRCA1 USP1 PMC5629289__F2 IFNA2: The prototypic human alpha interferon STAT1 STAT2 IRF9 TYK2 JAK1 PMC7426442__F3 SARS-CoV-mediated evasion of host innate immune response STAT2 IRF3 ACE2 PMC6149701__F1 Dual Regulation of NFKB signaling by SIRT6 SUV39H1 SIRT6 SKP2 PMC6161481__F8 The proposed pathways activated by LPS to modulate mTOR-dependent autophagy and the production of pro-inflammatory cytokines in Caco-2 and HT-29 cells TLR4 MYD88 MTOR MAP3K7IP1 IL1B PMC8489073__F6 Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges RIT1 IGF1R SNAI1 EGFR NRAS PTEN MTOR HRAS IRS1 AURKA NF1 RET SOS1 PMC3341105__F2 Signal transducer and activator of transcription 3 (Stat3) signaling CD44 SRC MTOR PMC7947625__F1 Mevalonate (MVA) pathway and its connection with the intracellular energy metabolism signaling HEL-S-26 IPP PMC9367564__F1 Versatile Triad Alliance: Bile Acid, Taurine and Microbiota CYP8B1 PYY FGFR4 CYP7A1 PMC8683177__F1 Tumor-Specificity Growth Factor Combined with Tumor Markers in Nuclear Medicine Imaging to Identify Prostate Cancer Osteonosus BAD LTA CD2 GRB2 TRAF6 SYK MYD88 BAX CBL PMC3507315__F2 T cell receptor signaling pathway extracted from BioCarta database FYN PLAT ZAP70 GRB2 JUN LAT PMC3507315__F3 Fc epsilon receptor I signaling in mast cell pathway extracted from BioCarta database BTK LYN GRB2 SYK PMC3507315__F9 mTOR signaling pathway extracted from KEGG database TSC2 RICTOR BRAF EIF4E MTOR RHEB PMC7317062__F1 Neurofibromin is a negative RAS regulator NF1 NF2 EGFR TYK2 LATS1 JAK1 MTOR LATS2 PMC2981516__F6 Demosponge EST Sequencing Reveals a Complex Genetic Toolkit of the Simplest Metazoans ELL PMC9469581__F5 TRIM proteins in hepatocellular carcinoma PML TRIM7 TRIM71 SMAD2 SMAD4 PTEN TRIM25 TRIM59 TRIM65 TSC2 TRIM52 TRIM32 TRIM66 SRC ARC TRIM28 TRIM24 TRIM44 TRIM37 BAX PMC4924289__F1 Summary of the signalling pathways known to control the switch between dauer and growth in C IGF1 PPM2C INS NCR1 NCR2 PMC2948292__F1 Potential roles of BLM and RECQ5 in sister chromatid exchange regulation BLM F3 RAD51 PMC5008074__F3 MicroRNA (miRNA) biogenesis pathway and its regulation by Smad proteins DGCR8 DROSHA RAN TF PMC6390811__F1 GPCR/Beta-arr-dependent signal pathways controlling cell survival, cytoskeleton remodeling, and gene expression, leading to enhanced cell growth, invasion and metastasis HEL-S-28 RALA SRC ARHA MTOR TCF4 PMC3834580__F2 Future of targeted agents in metastatic colorectal cancer EGFR GRB2 MTOR PMC2013735__F4 GenMapp pathway showing the impact of 1 week of STZ-DM on transcription in pathways related to cytokines and the inflammatory response GNAT2 GEM WAS PMC6863766__F5 Metabolomics study of fasudil on cisplatin-induced kidney injury ACD PMC4856801__F1 Proposed model depicting the opposing roles of type I and type II NKT cells in inflammatory diseases in the liver CCR6 HEL-S-70p IFNG PMC6470438__F6 Activating p38 MAPK intersection signaling pathway STAT1 MAPKAPK2 MAPKAPK3 RAC1 CDC42 PMC4022190__F7 Biosynthetic pathway leading to the hypermodified tRNA base wybutosine (yW) TYW3 TYW1 PMC9099196__F4 Gut homeostasis, injury, and healing: New therapeutic targets GRB2 ARHA RAC1 PMC7970828__F6 Synthesis Pathway and Protein-Protein Interaction (PPI) Network of the Elevated IGPs Modified by HM Glycans in Tumor TNC GGH GNS HEL-S-84 PLOD1 CTSC PSAP PRKCSH HEL-S-130P MAN1A1 PMC3056511__F7 Schematic summarizing the present findings ELF3 NGF EIF4E MTOR PMC5362350__F1 Role of Autophagy in HIV Pathogenesis and Drug Abuse ULK1 ATG12 ATG10 MTOR ATG14 DKFZp686F0183 PMC4424331__F11 The molecular mechanism of iron-induced RPE C3 production involves ERK1/2, SMAD3, and C/EBPD signaling CEBPD HEL-S-62p PMC4943391__F2 Melanocyte differentiation pathway dependent on MSHA and ACTH MC2R CREB1 TYRP1 PMC3318211__F1 Signaling pathways involved in anthracycline-induced cardiomyocyte injury BAD ERBB2 GATA4 BAX PMC8696122__F8 Brain and Pituitary Transcriptome Analyses Reveal the Differential Regulation of Reproduction-Related LncRNAs and mRNAs in Cynoglossus semilaevis GNRHR MMP2 EGFR GRB2 HBEGF FSHB LHB PMC8890943__F13 Potential mechanism of MET alleviating COPD and CSE-induced GC resistance through activating Nrf2/HO-1 signaling pathway, which can promote the function and expression of MRP1 to increase the expression of HDAC2 GCGR KEAP1 GC HDAC2 PMC9109253__F1 Novel Small Molecule Approach for the Treatment of Propionic and Methylmalonic Acidemias. HEL-S-62p NAGS PMC4682803__F1 MTORC1 signaling to the translational machinery LARP1 DEPTOR EIF4B MLST8 PMC3962547__F14 Integration of metabolic control, cell growth and proliferation, and their regulation by phosphoinositides TSC2 RHEB PMC5755497__F7A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation SALL4 FGF4 SOX2 NODAL APC ZIC3 UTF1 DVL1 PMC5845450__F1 Central metabolic pathways of Geobacillus LC300 based on the genome annotation TAC3 CIT MAL PMC6940594__F4 ILK Signalling pathway generated using IPA COX2 LEF1 BMP2 MMP9 NACA HEL113 HEL114 TNF KRT18 PXN PMC3888279__F3 Regulation of hypoxia-inducible factor (HIF)–A expression or stabilization by pathways other than hypoxia RET IGF1R EGFR MDM2 RBX1 SUMO1 PMC8824234__F2 Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations RUNX3 ACVR1 RUNX2 SOST LRP5 LRP6 SMAD1 SIRT1 PMC11841850__F1 Heme biosynthetic pathway and multisystemic manifestations in EPP and XLP FECH UROD UROS CPOX ALAS2 PMC3237908__F4 Schematic diagram shows the possible effect of xanthones on the apoptosis pathways FADD BAX PMC5462749__F8 Working model of Beta-Lap in acute pancreatitis NLRP3 HMGB1 SIRT1 PMC11173086__F9 Proposed regulatory network of bulbil initiation in P SNRK RAX TF PMC5037829__F2 UPR mechanism ELF2 ATF4 TRAF2 BAX PMC5460122__F6 Lipotoxicity-induced NLRP3 inflammasome activation in TEC NLRP3 TLR4 LDLR IL1B SIRT1 CD36 PMC3342643__F5 Diacylglycerol kinases in immune cell function and self-tolerance IRAK1 GSK3B TRAF6 IRAK4 MYD88 PMC8961591__F1 Pathophysiology of H2S in Renal Glomerular Diseases DAO PMC5755497__F8A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation VEGFC VEGFD GRB2 VEGFA VEGFB PMC3744053__F5 Signaling pathways of anti-permeability factors VEGFA SRC PMC6953027__F2 Signaling and gene regulatory networks in pluripotent (naїve and primed) and teratocarcinoma stem cells EGF TCF3 HGF SOX2 NODAL CRIPTO DUSP9 LIF SMAD6 ID1 FOXD3 GIG8 CDX2 MAX ESRRB CD2 KLF4 KLF2 CDK4 GSC BDNF PMC6953027__F1 TGFB Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer GDF6 EGF BMP6 gdf7 HGF NODAL CRIPTO BMP2 LIF SMAD6 TRAF6 GDF1 TNF BMP4 BMP10 BDNF JUN TGFB1 GDF3 PMC3070859__F1 Cohesin regulates expression of genes that control differentiation, morphogenesis, proliferation, and pluripotency MYC NIPBL STAG2 PMC6894227__F1 Metabolic pathway of DEGs related to lipid metabolism in the liver by DNA microarray analysis CYP46A1 FACL4 FDFT1 AKR1D1 DHCR24 ACSL1 CYP7B1 HEL-S-104 EHHADH CYP7A1 PMC4969764__F3 STRING v10.0 protein–protein interaction network based on input of 164 proteins of interest ARFGAP3 CARM1 TPR PRRT2 PRNP RIMS1 APLP1 APBA1 HNRNPUL1 SNW1 ARVCF HNRNPF ATP2B4 AIP UBXN2B MRPL38 PTBP1 WNK1 C14orf133 SEC11C GFOD1 CRMP1 SRSF10 RPS9 PRPF19 MRPL40 TAGLN TIAM1 PIP4K2B FAF2 SYDE2 PLCH2 PMC9369123__F4 PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications VCAM1 BAX PMC8490125__F3 Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases NLRP3 COX2 TLR4 TXNIP MYD88 IL1B GSDMD PMC11754893__F8 Mechanism diagram of MH regulating S100A8-CAMKK2-AMPK axis against cerebral IR injury S100A8 BAX CAMKK2 PMC12182054__F1 FGF19-FGFR4-KLB signaling pathway FRS2 GRB2 FGF19 FGFR4 PMC9454615__F5 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication IRF7 TRAF3 TRAF6 IRF3 MYD88 TRPA1 TLR3 TMPRSS2 PMC2621116__F2 Representative plasmids used in this study HBD ETFA PMC11953998__F5 Schematic illustrations showing different nano-targeting systems achieving precise mitochondrial localization and killing tumor cells through mtDNA perturbation (a–b) and metabolism disruption (c–d) TBK1 CGAS IRF3 TFAM PMC7564652__F3 AD pathway with target genes of upregulated miRNAs highlighted SNCA AFP TUBB BAGE RTN4 APC ABO INS FES CASP3 APAF1 LPL APP CASP9 ACD TRAF2 FADD PMC7564652__F4 AD pathway with target genes of downregulated miRNAs highlighted SNCA AFP BAD TUBB APC ABO INS IL6 TNF MTOR INSR LEP LPL APP ATR TRAF2 FADD PMC9454615__F2 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication KEAP1 TRPA1 PMC9454615__F3 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication MAS1 ACE2 TMPRSS2 PMC2868782__F3 Comparison of protein and gene expression studies SAFB POR MTOR PMC3668182__F2 Specification of GABAergic Cortical Interneurons DLX2 SST LHX6 GSX1 DLX5 LHX8 GSX2 DLX1 DLX6 NPY SHH ARX SOX6 PMC4521019__F2 Regulation of hepcidin expression by iron and inflammation BMP6 HFE JAK1 SMAD1 DKFZp781O1323 TFR2 STAT3 PMC3833184__F3 Lineage-specific positive selection in the naked mole rat BRCA1/FANC pathway FANCD2 BRCA2 RAD51 FANCA BRCA1 FANCE FANCG FANCF PMC4931664__F1 Canonical NFKB pathway (left) induced by signals including antigens, TLR ligands and cytokines such as TNF uses a wide variety of signaling adaptors to engage and activate the IKKB subunit of the IKK complex BCR RELB CD40 PMC6331247__F2 Pathway for the relationship between MS4A6A SNPs, blood gene expression and Alzheimer’s disease phenotype AGA MS4A6A PMC7836472__F5 Network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer ERBB2 EGFR MYC CCND1 IL6 RAF1 MTOR PMC8537037__F2 Abscopal Effect: A Review of Pre-Clinical and Clinical Advances HMGB1 CGAS TLR4 CD80 CTLA4 PMC7664031__F7 Common altered signature as effect of multiple dose exposure to doxorubicine a Common altered up- and downregulated genes between P12 and P24 in Hs578T and MDA-MB-231 ABCC3 EPHX1 TNFSF10 RRAD FHAD1 TNF CYP21A2 MX1 PMC4732619__F7 FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc SMAD4 FOXC2 SMAD1 DKFZp781O1323 PMC3601410__F1 Nrf2 is bound to Keap1 in the cytoplasm MAF KEAP1 NQO1 PMC3601410__F2 Most of the studies on Nrf2 and obesity-metabolic syndrome have focused on liver and white adipose tissue FGF21 AHR NOTCH1 HEL-S-104 RXRA PMC7136349__F2 Targeting of the complement cascade in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis C9 C7 C6 PMC8516647__F4 Functions of the XAF-1 protein in promoting p53 mediated apoptosis XAF1 HIPK2 MDM2 SIAH2 PMC9699629__F3 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications TXNIP KCNK3 MTOR MLX STAT3 PMC8619339__F3 Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples ROCK2 RHOD INVS CBY1 APC SOST SKP1 RYK PC4 WAS POR PMC9699629__F1 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications WAC HAL TXNIP PMC3708286__F2 Signaling pathways that relate disturbed polycystin-mediated Ca2+signaling to cell proliferation TSC2 TSC1 SRC PMC7671657__F1 PI3K signaling pathway TSC2 TSC1 EGFR GYS1 PTEN FOXO1 PMC6482165__F1 Hypothalamic regulation of energy homeostasis in healthy (blue) and obesity (pink) POMC TLR4 NPY AgRP MC4R MC3R ARC FOXO1 STAT3 PMC6935452__F2 Canonical and noncanonical Notch signaling pathway NPB HEY2 SI PMC11315658__F5 Synergism between TMEM16A and EGFR in mediating the proliferation of tumors EGFR GRB2 CCND1 STAT3 PMC2751999__F6 LPA effect and signal transduction pathway STAT1 TSC2 TSC1 MYC MAPK14 GIP RHO LPA RAF1 LPP MTOR PMC11083695__F1 Canonical hedgehog signaling pathway acts after the hedgehog (HH) ligands join the Patched-1 (PTCH-1) to release Smoothened (SMO) and enhance the translocation of glioma-associated oncogene (GLI) into the nucleus SUFU SMO HOXD8 FOXF1 PMC11083695__F2 Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma HEL164 SMO RHO MTOR PMC4007467__F11 Proposed integrin signaling switch model FYN SRC PMC9137930__F4 Flavonoids-Based Delivery Systems towards Cancer Therapies APAF1 BAX PMC7058935__F11 Wnt5b integrates with Fak1a to mediate cell movements during gastrulation DAAM1 SRC RYK RAC1 WNT5B CDC42 PMC8500950__F1 Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome NLRP3 IL1B NQO1 PMC10627266__F5 CEBPB increases inflammation/SASP independent of DDR pathway to promote senescence ATM CXCL5 CXCL2 IL6 IL12A ATR CEBPB PMC2836783__F2 CD62L regulation by T-cell receptor (TCR) stimulation and Gc-cytokines IL15 FYN LCK ZAP70 CCR7 IL7R IL2 IL15RA KLF2 MTOR FOXO1 ADAM17 PMC3364461__F4 PI3K/mTOR signaling at the FSHR TSC2 GSK3B FSHR PTEN RPS6 MTOR RHEB PMC6611790__F5 Hypothesis of the mechanism of IDH mutant gliomas BBOX1 PC TET2 PMC9399632__F3 Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics TRADD TRAF2 FADD BAX PMC3364461__F1 Multiple transduction mechanisms induced at the FSHR EGFR CDK4 FSHR RPS6 APPL1 PMC3594038__F1 Btk activates antiapoptotic pathways BTK BAD MDM2 PMC5276719__F2 Interconnections Between Autophagy and Integrin-Mediated Cell Adhesion EGFR AMBRA1 SRC BMF BAX PMC12150590__F5 Timeline of clinical trials of drugs targeting Wnt/Beta-catenin signaling pathway LRP5 PORCN DKK1 PMC12150590__F3 Wnt/Beta-catenin signaling pathway in cancer development and drug resistance HEL-S-302 VASP GPX4 FOXM1 TUBB6 SETD1A CDK12 PORCN TM7SF2 CDK6 CAVIN1 HEL-S-112 EZH2 DDX5 TM4SF1 USP6NL KDM1A RUNX1 APC LRP5 LRP6 TSPAN1 FAT4 NINJ1 C5AR1 CDX2 SP4 RNF128 EPHB2 HEL-S-29 SEC62 PMC3403928__F4 Caspase cascade HEL-S-62p C8A TNF PMC12150590__F4 Therapeutic strategies of targeted drugs in Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PORCN PMC12150590__F1 Mechanism of canonical Wnt pathway APC GSK3B LRP5 LRP6 PMC12150590__F2 Mechanism of non-canonical Wnt signaling pathways NLK APC ARHA JUN CDC42 PMC6893874__F1 Diphthamide biosynthetic pathway DPH2 DPH5 DPH6 DPH7 PMC8663935__F4 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions ULK1 TSC1 TFEB PTEN RHEB PMC8573099__F6 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule GAD2 SLC27A2 DAO BCAT2 GPT GCK TPO PAH GAA CLC PC EPX GPT2 SI PKLR ME3 HEL-S-133P HK2 HEL-S-281 ChAT FARSLA GANAB SHE DLD TTL IMPA2 LDHD CHKA FARSB SETD5 EHHADH TH MPO HADHB ACHE BAAT PLD2 AGA DDC FARS2 AGXT CAD DLAT GLA MGAM CTH HK3 MIOX LPO ASPA LGALS13 HACL2 CPA6 CPA3 GANC ASNS CHKB AASDHPPT pcap LCT PMC8573099__F7 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule CTH GAD2 IMPA2 EIF4EBP3 BCAT2 YARS2 DLD GCK PAH HEL-S-281 PMC8423577__F3 Remodeling of Macrophages in White Adipose Tissue under the Conditions of Obesity as well as Lipolysis COX2 SOCS3 SPHK1 GDF3 STAT3 PMC9020200__F3 Cardiovascular informatics: building a bridge to data harmony TMEM11 SAMM50 PACSIN1 SP1 RAPGEF2 PMC6533522__F2 SUMOylation‐mediated signalling pathway of cardiac hypertrophy SUMO3 SUMO2 HSF2 SUMO1 PMC12016104__F1 Metabolic pathway of the engineered G PDC TNLG7C RPE PMC8663935__F1 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions ULK1 TSC1 TFEB GRB2 PTEN DEPTOR RHEB MLST8 PMC8663935__F2 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions ULK1 ATG16L1 ATG12 ATG3 WIPI1 AMBRA1 ATG101 UVRAG ATG10 DKFZp686F0183 PMC8266377__F2 Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC11973335__F1 MPC mesengenic and angiogenic differentiation pathways are mutually exclusive DLL4 MSC PMC6996551__F1 Cyclin D1–CDK4/6–RB and PI3K/AKT/mTOR pathways in BC TSC2 EGFR CCND1 CDK4 MTOR CDK6 PMC6384427__F2 NFKB and IRF3 signaling pathway regulation by miRNAs implicated in inflammatory diseases TRADD IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 PMC5979333__F2 The NF2/merlin signaling pathway LIN28B AMOT MYC CD44 LATS1 MTOR LATS2 RHEB TSC2 PATJ TSC1 PALS1 DCAF1 PMC8856834__F3 Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis BTRC CEMIP SOX9 PMC7997185__F1 NEK1 and NEK2 play key roles in the DDR pathway NPM1 TLK1 VHL SSB MRE11A ATM ATRIP MSH6 NEK2 CDC2 FANCA ATR NEK1 PMC5743230__F2 HYPOXIA AND PLACENTAL DEVELOPMENT EPO EP300 VHL HIF1A COMMD1 HIF1AN CITED2 HEL-S-68p PMC7997185__F3 Possible involvement of NEK6 and NEK7 in DDR NEK6 ATM ATR PMC7997185__F5 Signaling pathway of NEK10 and NEK11 upon DNA damage ATM RAF1 CDC2 NEK11 ATR PMC3934873__F1 Iron Transport Machinery of Human Cells: Players and Their Interactions STEAP3 HP CD163 TF PMC2169177__F10 Schematic view of Ras- and calcineurin-dependent pathways in T cells RASGRF2 SOST VAV1 ZAP70 IL2 RAC1 CD69 PMC4369815__F6 Schematic diagram of the signalling pathways involved in DEHP-induced Beta-cell dysfunction HEL-S-11 ATF4 EIF2A PMC3535184__F4 Ingenuity pathway analysis reveals the close relationship between 14 of 17 of most relevant genes in rectal cancer MYOT MMP25 CLDN1 ETV4 TRIB3 FUT1 CEBPA ASPN FGF18 TNF IFITM1 ANGPTL1 MMP2 GDF15 CEP72 SMPDL3A MEF2C PMC7122270__F2 Type I/II cells FADD PMC2593676__F6 Gene expression and metabolite levels in the distal network pathways related to Met- and Trp-derived GS biosynthesis HEL-S-64p CBL PMC5755497__F11 Ingenuity pathway analysis of differentially expressed genes unique to emerin-null cells during transition from day 1 to day 2 of differentiation EGF FLNA APC ANKRD2 ARHA MYH7 TTN HIF1AN FOXF1 GNG12 ALPK3 PI3 HEY2 CAV3 GRB2 LBP SRC HEL114 MEF2C PXN TRIO CDC42 PMC5755497__F12 Ingenuity pathway analysis of genes differentially expressed during the transition from differentiation day 0 to day 1 common to emerin-null cells and wildtype cells BOC SOCS3 ANKRD2 SMAD4 BMI1 SMYD1 RB1 PAK1IP1 CAV3 ATM RIPOR2 MDM2 SIN3A CXCL14 MBNL3 ANGPT2 CXCL10 NRG1 CEBPA FOXO1 ID3 HIF1AN CASP3 TRIM54 MAX SUV39H1 ASB2 CDK2 ATR TNFAIP3 SOCS1 PMC7931689__F2 Identification of a functional network and laryngeal cancer-associated DEGs from the red-green overlapping DEGs SPARC MYCT1 LAMB1 THBS2 POSTN VCAN COL1A2 COL10A1 NID2 PMC9645326__F2 Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections ALB CTSA ACE2 PMC8687399__F10 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy CASP3 INA CASP12 HEL-S-11 TRAF2 BAX PMC7944918__F8 Gene ontology enrichment analysis of co-upregulated DEGs in both systemic sclerosis and lung cancer CD14 CTSK TLR9 CD6 TRAF3 TRAF6 IL6 RAC1 TLR4 LBP CD40 FADD TIRAP PMC8083443__F1 Immunohistochemical analysis of Nuclear Factor-kappa B (NFKB) between follicular and plexiform ameloblastomas: A pilot study CD14 TRADD DAO TRAF3 MYC LTB POR LEP LTA BCR BASH CYLD LYN SYK LTBR LAT TIRAP PMC3035636__F1 Targeting Metabolic Remodeling in Glioblastoma Multiforme HEL-S-26 MYC HEL-S-133P HK2 PMC12124647__F7 Relationship between Oxidative Stress and Angiogenesis in RA CGAS MPO XDH OGDH TNF PMC12124647__F8 Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies VEGFA SRC SPHK1 MTOR PMC3245201__F1 Topography and signaling pathways triggered by selectin ligands in neutrophils BTK c-fgr LYN CD44 SYK PLCG2 PMC12124647__F6 Impact of Glycolysis in RA Angiogenesis F2 ARHA PMC12124647__F4 Abnormalities in EPC Phenotype and Vascular Barriers in RA Synovium CXCL13 VCAM1 CXCR5 PMC6581914__F10 Scheme and working model PC IAPP PMC6966445__F1 Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways (simplified) STAT2 IRF7 IRF9 IFNGR2 IFNAR2 IFNAR1 CRKL STAT1 RS1 TYK2 JAK1 IFNGR1 STAT3 PMC3037729__F1 Interaction between PI3K/Akt and Wnt signaling pathways mediates diverse cellular effects through downstream messengers GSK3B MTOR FOXO1 PMC6830099__F6 Putative model for the role of WIP1 in HR and in PARP inhibitor sensitivity PARP2 PARP1 BRCA1 PMC3944966__F1 p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock ENO1 PAH PMC4243732__F1 Cyclooxygenase and 5-lipoxygenase pathways with special reference to aspirin exacerbated respiratory disease GPR17 LTA COX1 PMC2631376__F3 Hypothalamic Malonyl-Coenzyme A and the Control of Energy Balance POMC NPY AgRP PMC2919048__F7 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines ROCK2 NODAL PITX2 TGFBR1 SKP1 ARHA RBX1 SMURF1 LTBP1 IFNG FST SMURF2 THBS1 TUB SP1 SMAD1 DKFZp781O1323 PMC2919048__F8 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines CD14 NGF MOS FLNA EGFR MAP3K7IP1 HEL-S-162eP NLK PAK1 MAX PATE2 GRB2 ECSIT RAF1 BDNF TRAF2 JUN PMC8199681__F1 Molecular Details of the Frataxin–Scaffold Interaction during Mitochondrial Fe–S Cluster Assembly ABCB7 FXN ISCU PMC2277413__F4 Gene Network A MYBL2 NCOR1 EBP RAB4A TRIM28 PTEN KLF6 AURKA TLE2 SMARCC2 SAP30 CITED2 PMC7346436__F8 Pathway signalling network of the common gene regulators associated with the top-ranking 100 CpG sites SNAI1 MAPK3 PIP4K2A OSBP MAST2 BHLHE41 RAP1GAP SETBP1 CDON SET RIF1 WASF1 BAIAP2 PRKX MAP3K5 SRGAP3 AURKB DAAM1 BCORL1 MEF2C ARHGEF18 PLCG1 BAD BTRC RUNX2 ROCK1 CTBP1 EGFR TPR ROBO4 PTEN SLIT2 HDAC5 FOXP3 MEF2D BTK ERBB4 PTPRG CAMK4 ATM PPP1R14A MAML2 PKD1 GJB2 NCOA1 PTRH2 NCOR2 SSH1 RBPJ CAMK2D NR3C1 KCNB1 ARID1B RELA LYN JAK3 PI4KB PMC2277413__F5 Gene Network B CREG1 HCFC1 CDKN2B BDP1 KLF10 RB1 SP1 ID1 PAX3 KLF6 HDAC1 HEL-S-29 PMC4038991__F4 Circadian Redox and Metabolic Oscillations in Mammalian Systems CRY1 PDE1B NAMPT CRY2 NPAS2 PER2 PER3 PER1 PMC7093020__F2 Overview of crosstalk pathways associated with renal fibrosis and inflammation EGF IL18 SMAD2 SMURF2 EGFR TGFA SMAD1 PMC4669103__F4 Role of Innate and Adaptive Immunity in Cardiac Injury and Repair FYN TLR4 IRF3 MYD88 PMC3228878__F1 Several types of TG2-containing adhesive / signaling complexes present on the cell surface LRP5 SRC LRP6 ARHA PMC6944044__F2 Linc00152 is involved in protein activation NCL EGFR PTEN BRCA1 PMC7492540__F1 Schematic of known pathways regulated by AR in various breast cancer subtypes FOXA1 MYC PTEN WNT7B SOX4 PMC9250250__F5 Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method F13A1 PML HEPACAM TUBB6 FBN1 STX1A HEL-S-128m S100A6 CLU ACOX1 HEL-S-2a ARHGAP1 ELAVL1 SNCG RAB5B TLN2 HEL-S-11 CCT7 HEBP1 PCBP1 COL6A1 CYB5R3 PFDN2 FKBP4 PDHX PPP2R2A HEL-S-133P APOE PTGES3 BAX GFAP CD44 TNF HEL-S-21 GNG12 TPD52L2 ATP2A2 TUBB4A DUSP3 PMC8852695__F8 Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling IRF7 NODAL GSC PMC8454773__F1 Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals FPGS UCP2 PMC7431475__F11 Additional examples on TA-based MECs SMO MME PMC11703843__F1 LLPS and signalling pathways in the cytoplasm of healthy liver cells and HCC cells IRAK1 IRAK2 TRAF6 IRAK4 FRMD6 TAB3 PMC8756734__F1 Biological Clock Pathways Are Complex and May Yield Variable Outcomes EPO MTOR SIRT1 PMC10036500__AF1 MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway APC TCF4 PMC3291787__F1B Targeting the EGFR signaling pathway in cancer therapy EGF HRG BTC HBEGF TGFA PMC6682713__F1 LncRNAs regulate angiogenesis through modulating multiple signaling pathways ANGPTL4 VEGFA AGGF1 HIF1A MTOR STAT3 PMC6707130__F1 Developmental Alcohol and Circadian Clock Function AVP BDNF VIP PMC10675562__F6 HS potential inhibitory mechanism of GA via TGFB/Smad signaling pathway SMAD2 SMAD4 PMC2724779__F1 Complexity of sphingolipid biosynthetic pathways CERS3 LASS1 CERS5 CERS2 CERS6 PMC7189493__F7 Effect of X-rays on transcript expression of rat brain microvascular endothelial cells: role of calcium signaling in X-ray-induced endothelium damage PLN CD33 BCR CAV3 MCU PMC7930566__F2 Schematic portrayal of the possible mechanisms of mifepristone as a chemo-sensitizing agent for glioblastoma BCL2 BAX PMC4421107__F1 Energetic and biosynthetic functions of de novo lipogenesis (DNL) in the control of metabolic homeostasis CIC ACLY PMC8600187__F4 Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity TLR4 IL13 IL6 MYD88 IL4 NQO1 MAL PMC8259581__F1 Corrigendum: Signaling Pathways Regulating Thermogenesis ZC3H10 NRF1 UCP1 ATF2 TFAM PMC9322645__F8 Molecular Processes of Dodder Haustorium Formation on Host Plant under Low Red/Far Red (R/FR) Irradiation H1-0 CAD PRX PMC8259581__F2 Corrigendum: Signaling Pathways Regulating Thermogenesis COX2 BMP7 WNT10A SMAD1 DKFZp781O1323 PMC7295575__F5 Summary of the proposed pathway PIEZO1 NOTCH1 NACA2 ADAM10 PMC8817700__F1 Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials HMGB1 TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC3432650__F1 How does Lin28 let-7 control development and disease? LIN28B DGCR8 DROSHA LIN28A PMC3770684__F3 SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women MAF KEAP1 MDM2 ABCG2 PMC4576673__F5 Summary of endogenous pathways of AHR ligand synthesis AHR PTGS2 VEGFA IL22 IL6 PMC5578145__F8 Changes in the photosynthetic electron transfer chain, Calvin cycle, and biosynthesis pathway of sucrose and starch in response to rapid changes in temperature in M PC FES HEL-S-162eP PMC4600508__F2 Schematic overview of the multiple signaling pathways to apoptosis, necroptosis and autophagy TRADD RIPK3 TNF FADD MLKL PMC6288939__F4 Expression differences in males and females in response to reduced insulin signaling for immune response genes TH EPO POLE SPG20 ATF2 DAP PAH FADD PMC7677403__F2 Toll-like receptors (TLRs) mediated signal transduction pathway TLR8 TLR7 TLR9 IRF7 IRF3 MYD88 TLR3 PMC9685408__F2 Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation SOX18 CHD4 PROX1 ETS2 FOXC2 SOX17 PMC7677403__F3 cGAS/STING- mediated signal transduction pathway TBK1 CGAS IRF7 IRF3 PMC6288939__F6 Expression differences within the IIS/TOR pathway for the four comparison types MYC PTEN RPS6 MTOR PMC12061282__F10 Schematic depicting the mechanisms by which miR‐31‐5p regulates M1/M2 balance in autoimmune dry eye P2RX7 NOS2 PMC5770784__F1 Schematic drawing of the interactions between AB(1‐42) and IGF‐I receptor signaling IGF1R GSK3B BDNF PMC7677403__F1 RIG-I-like receptors (RLRs) mediated signal transduction pathway IRF7 IRF3 MAVS PMC7795494__F2 Comparison between the opposite effects of probiotics and early-life use of antibiotics in NOD mice IL10 PLN TLR4 MYD88 MLN PMC8070500__F2 JNK pathway in CNS pathologies ATF3 KLF9 PMC8070500__F1 JNK pathway is conserved between mammals and flies FOS UNK TNF JUN TF PMC3161872__F1 Summary of TNFR signalling TRADD TNF TRAF2 FADD PMC4470683__F7 Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action CDKN1A MYC STK11 SP1 PMC4988307__F1 Sulforaphane regulates Keap1-Nrf2-ARE signaling pathway and induces phase II metabolic enzyme expression KEAP1 SFN PMC9524954__F7 Alpha-KG production pathways that add net carbons to TCA cycle from glutamine GOT2 GPT2 SLC25A1 PMC6571700__F8 Signaling pathways modulated by EV miRNAs associated with T2DM NOTCH2 KAT2B IGF2BP1 ACVR1 NOTCH1 TGFBR3 IGF2BP2 FOXO1 SOCS1 INSR PMC2516940__F2 Sepsis and insights from clinical trials TLR4 IRF3 MYD88 MAL PMC5361607__F1 PRKCD-AKT-MTOR-ULK1 signaling pathway for autophagy suppression in cisplatin nephrotoxicity ULK1 SRC MTOR PDPK1 PMC3390502__F8 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells CCL20 IL1B SIRT1 PMC7677403__F4 Inflammasome-mediated signal transduction pathway NLRP3 IRF7 IRF3 AIM2 TLR3 IFI16 PMC8163070__F6 Phloretin protection against pathogen-induced mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) TLR4 MAPK8 MUC5AC EGFR MAPK3 NOX4 MAPK1 PMC3761286__F1 Diagram showing Na-K-ATPase control of cell function by ouabain via its ion transport and signaling functions HEL-S-11 EGFR GRB2 SRC PMC8120650__F3 Autophagy-related signaling pathways are involved in cancer (Review) PLP2 FOXO3A MYC PTEN MTOR DEPTOR RHEB MLST8 TSC2 RICTOR TSC1 SBK1 BNIP3 SGK1 PMC8120650__F4 Autophagy-related signaling pathways are involved in cancer (Review) TSC2 ULK1 MTOR PMC8120650__F5 Autophagy-related signaling pathways are involved in cancer (Review) EGF COX2 KEAP1 LAMP2 ATF4 EIF2A BCL2 DKFZp686F0183 CDC42 PMC6923169__F2 Biosynthesis of N-glycoproteins in eukaryotic cells AIG1 FUT8 ALG1 ALG3 ALG13 ALG6 ALG10 GAL PMC6817752__F11 Schematic showing the proposed mechanism of action and regulation of HNRNPK/miR-7 ABCG1 KLF4 SP1 INSR PMC7463546__F1 NFKB signaling pathway and anti-multiple myeloma (MM) drug targets EGF TRAF5 RELA EGFR TRAF3 RELB TRAF6 CD40 TRAF2 LTBR PMC8109088__F8 Proposed model illustrated the role of hsa_circ_0110102/miR-580-5p/PPARA/CCL2 signaling in regulating HCC metastasis CCR2 CCL2 NR1C1 PMC3086058__F1 Representation of genes of the vascular endothelial growth factor (VEGF) signaling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib, and cilengitide are known to act PIGF CSK FGF2 VEGFA CRK FLT1 KDR FRS2 NRP1 TIMP3 GRB2 RAF1 SOS1 VEGFB PMC9599894__F5 Radiotherapy-Related Gene Signature in Prostate Cancer CD3D AMFR TNFRSF14 CD6 CCR7 BTLA EPS8L2 CCL23 MUC15 FCGR2B CD3G CD3E PMC11209433__F5 Interactions among genes involved in the type 1 interferon signaling pathway using STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) IFIT3 XCR1 CXCL1 TLR9 RNF31 CSF3 ACKR3 IL17F TRAF3 CXCL3 CCL2 IL31 FBXO6 HDC NCR3 MX1 GPX7 FOXP3 OASL ISG15 OAS3 CXCL14 SELE CXCL11 MGAM IL1F10 MAP3K1 CCL11 RSAD2 PTGS2 IL36A CXCL10 CXCR5 CXCL2 TRIM6 CCRL2 CBL CXCR3 CPA3 LEF1 IL36RN NFKB1 TRAT1 MME IFIT1 PMC8450384__F4 Glucose Metabolism and Glucose Transporters in Breast Cancer HEL107 HEL-S-133P PHGDH HK2 PMC5899410__F3 TREM2 mediated innate immune regulation in Alzheimer’s disease TNF IL1B PMC4232216__F1 BMP Family and Signaling Pathways GDF6 BMP6 BMP3 BMP1 gdf7 BMP2 BMP15 SMAD6 SMAD4 BMP7 BMP4 BMP10 BMP5 GDF11 SMAD1 DKFZp781O1323 PMC5468173__F4 An illustration of potential mechanisms in injury-induced vascular intimal hyperplasia is depicted TLR4 MYD88 PMC9163386__F6 Component 1 Inhibitor Missense (Val480Met) Variant Is Associated With Gene Expression and Sepsis Development in Neonatal Lung Disease IL10 PLAT C4B_2 PLG F11 MASP2 ELANE IL6 KLKB1 C1S TNF C4A PMC7354650__F4 Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke NR1i1 ADRA2A WNT4 NR3C1 INS HDAC2 OPRK1 NR3C2 DRD1 MED1 POR HIF1A PMC3557799__F3 Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting GET3 GET1 GET4 PMC9602906__F8 Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver NLRP3 TLR4 GSDMD PMC4641524__F4 Differential Somatostatin Receptor (SSTR) 1-5 Expression and Downstream Effectors in Histologic Subtypes of Growth Hormone Pituitary Tumors3.1 AIP SRC SSTR2 PMC3357464__F3 Scaffolds can organize pleiotropic kinases into stimulus-specific signaling modules to direct them to one specific pathway MAP2K4 TRAF2 TAB3 PMC5114727__F1 Enzymatic steps of the P PPCS PPCDC PMC11119900__F3 PAI-1 alters TME and regulates tumor cell migration and invasion DDR1 PLG PMC9506158__F3 ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle TBK1 TSC2 IRF7 MDM2 EIF4B PMC10041561__F17 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs OAS1 FABP5 IRF3 FAAH TNF TLR3 MX2 TRPV1 MX1 PMC11206879__F3 Alterations in major signaling pathways that have been identified in OS development and metastasis: PI3K/AKT/mTOR, JAK/STAT, Wnt/Beta-catenin, NOTCH, Hedgehog/Gli, TGFB, MAPK, and receptor tyrosine kinases (RTKs) LRP5 SMAD6 SMAD4 LRP6 PTEN MTOR HES1 VGF SUFU PTCH1 GRB2 SHH SMO STAT3 PMC7365123__F1 Putative association between ACE2 shedding after SARS-CoV-2 infection and the poor outcomes in elderly COVID-19 patients with pre-existing age-related cardiovascular, cardiometabolic and cardiorenal diseases MTOR ACE2 TMPRSS2 PMC10041561__F15 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs PROC TNF PMC6529740__F2 Potential and confirmed phenotypic features of C9orf72 HRE-associated microglia in FTLD/ALS C1QB C9orf72 RAN CD68 TYROBP PMC8000072__F6 Proposed pathway by which SCFAs regulate lipid metabolism in a sex-specific manner in Long–Evans rats TG CYP7A1 ACAT2 PMC2652039__F8 Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta activated kinase 1 TRAF5 VCAM1 TRAF1 TRAF3 CCL2 TRAF2 PMC5234130__F4 Terpene biosynthetic pathway, and heatmaps displaying the expression (log2 FPKM) of enzymes involved in the different reaction steps ME2 MVD TRO MVK IPP PMC8848383__F8 Activation of the AKT/GSK-3B/Beta-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage NFKB2 MYC CCND1 PMC9219473__F6 Iturin A Rescued STb-R-Induced Pork Skeletal Muscle Growth Restriction through the Hypothalamic-Pituitary-mTORC1 Growth Axis IGF1 EIF4E IRS1 GHRH PMC4760220__F7 AAV backbone alone has no effect on interferon activation IFIT3 IRF9 PIAS1 TYK2 JAK1 IRF-1 PSMB8 IFNG BAX IFIT1 PMC6438741__F3 At the intersection of DNA damage and immune responses BAD PIM2 FOXO1 SPIC RAG2 PIM1 PREB ATM BASH IL7R SYK IRF4 BAX PMC4891443__F5 Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 MMP3 IGF1R IGF1 PMC7711227__F2 CaMK, MAPK/ERK, and CaN Signaling From L-VSCCs to Transcription CRTC1 SIK1 PMC9516679__F9 Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between lamininG2 and integrinB1 CDH2 LAMC2 PMC6438741__F6 At the intersection of DNA damage and immune responses HEL-S-62p ATM CRTC2 UNG PMC7825147__F2 Tumor suppressor and promoting effects of the TGFB pathway COX2 GIG8 ANGPTL4 RAD17 ATM APC EGFR ID1 ID3 BAX PMC6459935__F1 Bioinformatics analysis of direct ERRA target genes in mouse liver NR1C1 RXRA PMC8828488__F1 ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis NLRP3 CD44 CNP TXNIP IL1B PMC7825147__F1 Transforming growth factor B (TGFB) signaling pathway SMAD2 SMAD4 UNK ARHA MTOR TF PMC6206158__F1 Complement activation pathway and regulation HEL-S-62p CD59 C4B_2 CD46 MASP1 FH C6 MASP2 C1S C4A CR1 PMC8257394__F4 Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC TH GALNS ADAM12 EZR HEL-S-92n NRG1 RPL4 CRK NAPA PATJ TSHR VWF CTSA TCHP USP42 BANP OSM PMC6540932__F6 Network view of infected dendritic cells CSF3 RELB IL12A MTOR NOD2 IFNG UBC DKFZp686L0365 ISG15 IL18 TLR4 NOD1 IL22 SRC EIF4B IL10 CCL4 RAC1 EIF4E MAP3K7IP1 TLR3 RHEB RNF125 TSC2 NR1C2 SYK RAF1 PMC5135602__F1 PPARD mediated gene regulation CPT1A JAG2 IL6 PDK4 BMP4 IFNG PMC3250080__F1 CR-associated signaling and some of its key players IGF1R IGF1 GHR IRS1 RHEB PMC8820534__F1 High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats CTH HEL-S-61p HEL-S-182mP SQOR SUOX pcap PMC4822853__F3 Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis IL27 IL24 IL6 IL4 IFNG PMC3023615__F2 In fibroblasts, Nod2 senses bacteria at the plasma membrane and recruits the autophagic machinery through direct interaction with ATG16L1 ATG12 ALG5 NOD2 PMC4309023__F6 Core Hedgehog pathway and its cross talks DHH IHH SUFU SHH SMO PTH PMC5578810__F2A Fanconi Anemia Protein Interaction Network: Casting A Wide Net REV1 ATRIP ATR PCNA CLK2 PMC3690688__F8 Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium KCNE3 CFTR PMC9144222__F10 Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways CASP3 ATF4 EIF2A CCNB1 BAX PMC6862548__F1 Pathways activated by several dysregulated hormones in central obesity ADIPOR1 ADIPOR2 CHUK BAD SOCS3 PTEN MTOR FYN NPY NFKB1 RELA GRB2 REL SOS1 STAT3 BAX PMC6862548__F2 Estrogen biogenesis, and its metabolism FLT1 SRC SP1 PMC8622245__F1 An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants TLR4 TRAF6 MYD88 PMC7919658__F3 Oxysterol and BA profiles by the hepatic endocannabinoid and immune system in male mice CYP27A1 CYP8B1 CYP7B1 FGFR4 MYD88 CYP7A1 PMC4668392__F1 Multiple regulation pathways and pivotal biological functions of STAT3 in cancer SRC RAC1 CDC42 STAT3 PMC11215460__F1 Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway PKP2 AQP3 AQP5 PMC8948438__F2 Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo MYB BAD CD37 PTEN RAC1 BRCA1 RHEB TSC2 MDM2 CYC1 SYK RBL2 ACR CD19 PMC2683291__F4 Mammalian target of rapamycin (mTOR) signalling cascade TSC2 EIF4E MTOR RHEB PMC2757047__F3 Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity CCK VLDLR TWIST1 CDK5 SEMA3D APOE PMC5362541__F2 Inhibition of cancer antioxidant defense by natural compounds KEAP1 RBX1 PMC4582071__F3 Intracellular pathways to canalicular and basolateral plasma membranes ABCB4 ABCB11 ABCC2 ABCB1 PMC12064105__F7 Mechanism diagram of XSBO against AD (drawn by Figdraw 2 COX1 ALOX5 SMS PMC8727999__F2 Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly CDON NODAL SMAD2 MKS1 GAS1 IFT172 FGFR1 PTCH1 TGIF1 SHH SIX3 ZIC2 TCTN3 FOXH1 PMC8329661__F2 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? APAF1 CDK4 CDKN2A CDK6 BAX PMC8329661__F3 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? EGFR GIP PTEN MTOR PMC5072448__F1 Molecular mechanisms and signaling pathways of ferroptosis GPX4 CS LPCAT3 FACL4 SLC7A11 FTH1 FTL VDAC3 HEL-S-102 IREB2 SLC3A2 FLT3 ACSF2 PMC9303011__F2 Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer SET MAX TF PMC7044202__F9 MAPK regulated induction of cytokines in IL-33 stimulated ILC2s IL33 PTEN MYD88 MTOR PMC11019147__F4 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging PLCG1 NFATC1 GSK3B TRAF6 RAC1 PMC8329661__F5 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? COX2 PTEN PMC7480187__F7 Alleviation prostate cancer progression via overexpresion of RIP3 CCNA2 CCNB1 CDC2 MLKL PMC10740485__F7 The proposed mechanism of Nrf2 in osteoporosis NFATC1 DCSTAMP TRAF6 PMC11019147__F3 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging ULK1 TRAF6 BCL2 KLF2 BNIP3 TET2 PMC11019147__F1 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging PLCG1 NFATC1 TRAF3 TRAF6 ORAI1 PMC5508477__F6 Representative scheme of the mechanisms involved in the induction of cell cycle arrest and senescence.MPM cell lines are frequently deleted in CDKN2A/ARF gene, coding for both p16INK4a and p14ARF MYC MDM2 CDK4 CDK6 PMC9454318__F5 Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway PIK3R1 IGF1R ID4 PGR EGFR GSK3B PAXIP1 ACHE COL1A1 CCNE1 FGFR1 KDR SCD PRKDC SLC30A4 CYP46A1 PSEN2 ID1 HEL-S-130P ID3 CASP3 GIG8 PSEN1 CDK2 CTSC PIK3CA BCL2 RORA PMC8306267__F2 Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria HEL-S-62p PLG F2 PMC5143376__F8 Hypothetical model of TMEM2 exerting its antiviral functions OAS1 IRF9 TYK2 JAK1 PMC4981961__F6 Phagocytosis and proteasome pathways INA VASP LAT SELL PMC6599063__F4 Simplified schematic representation of the affected pathways in an emerging honeybee worker that impact Varroa and DWV symptoms via their interactions SMAD2 RAC1 MTOR BCL6 PMC5683946__F2 NMD degrades mRNAs encoding UPR components ATF4 EIF2A ATF3 FSD1L TRAF2 XBP1 BAX PMC4742123__F2 Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer MID1 SRC PMC10217556__F1 Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain HMGB1 TLR4 CXCR4 CD74 PMC3883113__F6 Neurodegenerative diseases and widespread aggregation are associated with supersaturated proteins SNCA BAD CASP12 GSK3B CDK5 TNF CASP3 APAF1 LPL APP CASP9 OCA2 CASP8 FADD APOE PMC5480880__F6 Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies BRAF ERBB2 CAST ERBB3 GRB2 EPHA7 PTEN CRB2 PMC6431505__F6 Schematic graph of the proposed cardioprotective mechanism of H2 when rats were exposed to CIH ATF4 EIF2A XBP1 PMC11046830__F2 Glycocalyx degradation in LPS or septic conditions TFPI APC VWF TF PMC11046830__F3 Oxidative stress response in ECs NLRP3 FES NOX4 NOX5 PMC5683946__F6 NMD and apoptosis have a complex regulatory relationship I MAX ATF2 UNK GADD45A SGK1 PMC8968663__F1 Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol PC IDI1 IPP PMC11046830__F4 Cascade of effects resulting from the release of IL-33 under the action of endothelial injury and other factors MPO MMP2 VCAM1 MMP9 IL33 CCL1 STAT3 PMC12192587__F4 Muscle Fiber Phenotype Shifts in Response to ECM Coatings NRF1 CPT1A ACADM CD36 PMC4348787__F7 Fungus-induced changes in expression of the wheat jasmonate biosynthesis pathway SI PMC8375153__F1 Mechanisms of Sevoflurane-Induced Neuroinflammation SOCS3 SOCS1 PMC11968360__F1 Organoid models of ovarian cancer from three different sources STAT2 UCP1 BRCA2 FOXK1 ITGB6 HEL-S-133P HK2 PMC12211009__F10 BACE1-AS in the regulation of the propagation of C BCL2 IRF3 PMC4452147__F3 Schematic illustrations of a double-negative feedback loop and the ceRNA pathway HMGA2 PTEN PMC11506204__F3 Signal pathways of astragaloside IV in breast cancer VAV3 RAC1 FOXO1 PMC11506204__F1 Signal pathways of calycosin in breast cancer IGF2BP1 RASD1 RAB27B BAX FOXP3 BATF PMC11506204__F2 Signal pathways of formononetin in breast cancer IGF1 FPR2 CDK4 PTEN MTOR PMC2722780__F8 Putative BK-BKAP interactions derived from the BK interactome in mouse cochlea BAD SET LIN7C HEL-S-162eP PMC4048824__F2 Pathways for sulfide biogenesis and clearance RHD PMC3792444__F1 Induction of migratory heterogeneity during priming CXCR3 GC CCR7 CD44 CXCR5 EZR CD40 KLF2 CD80 FOXO1 IFNG BCL6 PMC8346999__F8 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases RIPK1 LIMK1 NEDD9 TRAF1 BMX UBR1 BRCA1 PMC8346999__F9 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases PINK1 UBR1 UBR4 PARL PMC8346999__F7 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases ATE1 UBR1 PMC8346999__F1 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR5 ATE1 UBR1 UBR4 NTAQ1 NTAN1 PMC9368818__F9 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy CASP3 TRIAP1 TAF9 PMC3342370__F1 Role of autophagy during innate immunity ATG12 DKFZp686F0183 IL1B PMC11007101__F2 Therapeutic prospects of nectin-4 in cancer: applications and value SRC ADAM17 PMC4693592__F2 Monocytes from MS patients cluster independently from HV and display enhanced inflammatory pathways TREM1 PMC10910240__F7 Mechanism of aerobic exercise combined with canagliflozin therapy against ISO-induced CHFCanagliflozin combined with aerobic exercise therapy modulates protein kinase activity CYP26B1 CYP1A1 ALDH1A2 PMC11534688__F11 Blestriarene C exerts an inhibitory effect on triple-negative breast cancer through multiple signaling pathways BAD GRB2 BAX PMC9114368__F8 Illustrative model to show the mechanism of circLIFR in HCC AGO2 PMC9084550__F2 Signaling pathways and therapeutic approaches in glioblastoma multiforme (Review) EGF LEF1 TCF3 APC EGFR GRB2 IQGAP1 CCND1 PMC4438184__F10 Aldosterone-induced inflammatory responses: role of the ADAM-17/TGFA/EGFR axis and modulation by paricalcitol STAT1 EGFR TGFA ADAM17 PMC7424765__F1 Postulated targets of action of B2-adrenergic agonists in DOK7 patients MUSK LRP4 PMC6291477__F2 AHR signaling pathway AHR CYP1A1 PMC9368818__F3 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy TAF9B TAF1 TAF1B TAF10 DKFZp781B1423 TAF1D TAF12 TAF13 TAF15 TBP MDM2 TAF3 TAF5L TAF6 TAF8 TAF7L TAF4 PMC10180667__F4 “Components-targets-pathways” network PIK3R1 CHUK PRKCZ MAPK9 GSK3B GCK HIF1A ITGB1 CCNE1 STAT1 PRKCA TLR4 MMP2 NFKB1 CDK2 MCL1 NOS2 PMC10180667__F5 Effect of FS on toll-like receiver signaling pathway CD14 CTSK TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR3 LBP CD40 FADD TIRAP PMC6085483__F2 Metabolic reprogramming of cancer cells in the tumor microenvironment (TME) TIGAR SCO2 MYC PTEN HIF1A MTOR GLS PMC6085483__F1 Metabolism is a key feature of every quiescent cell MTOR TG MAL PMC3581603__F6 Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells RPS6 MTOR BAX PMC8511446__F5 Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome SIRPA VAV1 ARHA RAC1 MERTK PMC8210610__F8 Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition CTSK NFATC1 MMP9 MVP PMC4001531__F4 Melanoma NOS1 expression promotes dysfunctional IFN signaling IFIT3 BRAF IRF9 GRK4 FYN RAP1A TYK2 JAK1 IRF-1 PSMB8 ADRBK1 IFIT1 BAX PMC6350303__F9 Molecular mechanism of ZNF326-mediated regulation of Wnt signalling APC HDAC7 AXIN1 ZNF326 TCF4 PMC7497304__F1 Models for the interactions between tumor cells and the tumor microenvironment in the brain CCR2 PTEN CTLA4 CCL2 TNF CSF1 STAT3 PMC9375293__F5 Targeting purine metabolism in ovarian cancer DHFR MTOR PMC5094991__F7 SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline EGF TRPC1 EGFR ORAI1 STIM1 PMC9375293__F1 Targeting purine metabolism in ovarian cancer ADSL ADA PNP PMC4877093__F2 IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling SMAD2 GSK3B MTOR MMP7 PLAT MDM2 SP1 LIMK1 PLAUR NCL PLG HEL-S-28 VAV1 LRP5 VEGFA ARHA DOCK1 RAC1 EIF4E HRAS WIF1 MAP3K7IP1 CRK NLK PAK1 VTN GRB2 CP CDC42 PMC9375293__F2 Targeting purine metabolism in ovarian cancer STAT3 PMC5584303__F2 Epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer E2F8 FOXM1 YY1 SP1 UHRF1 PMC3773757__F6 Summary of the convergence of the E2–ERK and mTORC1 signaling pathways in regulating migration and invasion in LAM patient-derived cells ZEB2 EIF4B RHEB PMC5858571__F4 Schematic of the predicted signalling pathways for HagB-induced MMP production in dendritic cells PLCG1 CCR6 IRAK1 ATF2 SMAD2 CREB1 TRAF6 PLCG2 MYD88 HIF1A CEBPB STAT1 MMP3 MMP7 MMP2 SP1 CD14 MMP10 MMP9 IRS1 PLCB1 MMP12 NFKB1 LYN CD40 SYK JAK1 RAF1 SHC1 PMC5555084__F1 Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors HEL-S-133P HEL-S-162eP PMC11491726__F2 Relationship of class I HDACs and NOXs in CVDs STAT1 HDAC3 KEAP1 NOX4 HDAC2 NOX5 HDAC1 IFNG PMC10511904__F3 Diagram illustrates how IMD activates various downstream signaling pathways through different CLR/RAMP receptor complexes GC GAA PMC11727316__F6 Molecular basis of Jusvinza’s mechanism of action on neutrophils CXCL1 TNFRSF14 SNAI1 IRAK1 LRRFIP2 RELB TRAF6 CCL5 IRAK4 PTEN MYD88 HSF1 MBOAT7 NLRP3 TLR4 MTDH HMGB1 MMP10 FLI1 HCLS1 YBX1 CDC37 DBI TRAF5 HELZ2 TRAF2 TIRAP PMC3100630__F1 EGFR biology TSC2 COX2 EGFR GRB2 TF PMC7916193__F6 Pathways involved in cutaneous squamous cell carcinoma (cSCC) pathogenesis EGFR GRB2 CCND1 CDK4 PTEN MTOR CDK6 HES1 IRF6 PMC5122717__F7 Model representing the interaction of Arabidopsis thaliana plants/Brevipalpus mites/CiLV-C AGO2 MYC ERF PMC9439701__F8 Specific microRNA Profile and Functional Networks for Children with Allergic Asthma GC INS RHO PMC7344258__F1 Cysteine is a core player in the cellular metabolism VIT PC MYC HEL-S-162eP PMC165090__F8 Schematic model for the roles of p120 catenin in the signaling pathways leading to growth factor–induced RhoA stimulation and cell migration SRC ARHA RAC1 VAV2 PMC8697442__SF1 Novel targeted co-delivery nanosystem for enhanced ovarian cancer treatment via multidrug resistance reversion and mTOR-mediated signaling pathway PGP CD44 MTOR STAT3 BAX PMC6523794__F4 PPI network for the upregulated genes in the AMPK signaling pathway ADIPOR1 ADIPOR2 LIPE FOXO3A SLC2A4 CPT1A PPP2R1A CD36 CAMKK2 PMC11834262__F8 Graphical abstract illustrating the mechanism of SS in treating BC GPX4 SLC7A11 EGFR CSA2 PMC6457213__F7 Model of cytokine-mediated rescue PIM1 PIM2 PMC3597489__F4 Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring FST ACVR2B NODAL RBL2 PMC9107479__F1 Extrinsic and intrinsic apoptosis pathways, indicating pharmacological agents and their therapeutic targets FADD IFNG BAX PMC9352753__F3 Identification of differentially expressed microRNAs as potential biomarkers for carcinoma ex pleomorphic adenoma PIK3R1 FZD3 MAPK3 MYC SMAD4 RB1 HIF1A CDKN2A FGFR2 E2F3 CCNE1 HEL-S-5 FGFR1 MMP2 ZMAT3 SMO MAPK1 ABL2 MAPKAPK2 TCF7L2 FZD4 APBB2 PPP3R1 IGF1 MAX STK4 BCL2 NR1C2 SESN2 FGF14 ARNT2 TGFBR1 TGFBR2 TPR RHO CCDC6 CCND2 FGF9 RRM2 THBS1 ACTN4 KIT RUNX1 BMP2 RAC1 CBL HEL-S-125m IKBKB CREBBP EP300 COL4A2 COL4A1 HHIP TRAF6 BCL2L1 CRKL PRKCA FZD2 MDM2 PTCH2 FOS VEGFA LAMB3 LAMB2 CEBPA PIK3R3 CRK FOXO1 HMGA2 ADAR GRB2 TP73 CCNG1 SHC4 ITGAV ATR LAMC1 IGF1R ZFHX3 HSP90AB1 EGFR TPM3 PAK4 PTEN EIF4EBP1 MTOR RARA SESN3 ATM E2F2 CCNB1 CCND1 FZD7 CDK4 JUN BAX FGF2 PTGS2 CAMK2G ITGB1 CASP3 RRM2B RPS6KB1 NFKB1 BBC3 RELA SOS1 FADD TRAF4 APPL1 STAT3 PMC8620413__F4 Lipid signaling in cancer DGAT1 TSC1 EGFR FABP5 PTEN ACLY MTOR LPCAT1 ACSL3 FASN CD36 PMC4076814__F6 Diagram depicting the role of GPX7 in regulating inflammation in esophageal epithelial cells CXCL1 TRADD TRAF2 GPX7 PMC4729111__F2 Metabolic pathway of l-Phe GOT2 DDC PAH PMC6862015__F5 Complement lectin pathway activation F13A1 C4BPB F10 PROS1 CS CD46 ALB HEL-S-99n WAS TXN CFI DKFZp686L0365 PRKCA DCN HEL-S-78p CFH CD2 CRP C7 F11 MASP2 ELANE FGA PLG HEL-S-92n C8A CD59 VTN FCN1 CFHR1 PMC9223478__F7 Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (Siniperca chuatsi) ATF4 EIF2A PMC5713242__F8 Cilia-dependent mTOR signaling TSC2 TSC1 RHEB PMC3174756__F5 Ephrin and neurotrophin signaling pathways in primary neurons NGF PMC6461988__F4 Reconstructed key metabolic pathways of Thermoprofundales based on eight MAGs (a) CS FH ACD PMC3174756__F6 CDK5 (A) and actin (B) signaling pathway in primary neurons NGF NGFR FOSB PMC7556532__F8 HER2-mediated enhancement of Ebola virus entry TYRO3 MERTK AXL PMC5713242__F3 Cilia-dependent Hedgehog signaling KIF7 SUFU PTCH1 SMO PMC7383016__F1 HR pathway in PTEN-deficient EC cells EGF PALB2 EGFR BARD1 PTEN MRE11A BRCA1 ATM BRCA2 MDM2 RAD50 RAD51 ATR PMC8752619__F4 Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli RORC NLRP3 BHLHB2 ABRAXAS2 P2RX7 NR3C1 TXNIP MAVS PMC11635689__S1 Metabolic Pathway of Conversion of 5-ALA to Protoporphyrin IX in Gram-Negative Bacterial Cells FECH UROD HMBS PMC7915189__F2 Some examples of signaling pathways involved in OS resistant tumor cells to conventional treatment GSK3B PTEN MTOR PMC8262654__F1 Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL-6/JAK/STAT3-mediated PD-L1 activity EGFR JAK1 STAT3 PDCD1 PMC9603448__F6 Engineered Human Intervertebral Disc Model Inducing Degenerative Microglial Proinflammation CXCL8 CCL5 IL6 CCL2 CCL3 PMC10892479__F4 Cytokine storm induced by SARS-CoV-2 proteins (ORF7a, ORF3A, M, and N proteins) mediated by the activation of NF-kB CCL11 CCL26 CCL21 CCL20 CCL17 CCL19 CCL25 TNF CCL27 PMC10892479__F5 Illustrates a diagrammatic representation of the intracellular signaling pathways activated by SARS-CoV-2 infection TLR8 TLR7 MYD88 TLR3 CCL3 PMC5572672__F2 Inherited and Acquired Disorders of Magnesium Homeostasis CLDN14 CASR CLDN19 CLDN16 PMC10892479__F2 Activation of the NF-kB signaling pathway induced by SARS-Co-V-2 and mediated by RIP/TRAF-dependent pathways or RIP-dependent/TRAF-independent IKKB activation TLR4 TRADD IRAK1 LTB IRAK4 MYD88 TNF MAP3K7IP1 TAB3 PMC10892479__F1 NFKB signaling (canonical and non-canonical) pathways BCR RELA RELB LTBR PMC7178465__F2 Danger-Associated Molecular Pattern (DAMP) binds to the Pattern Recognition Receptors (PRRs) expressed on the cytosol or in innate immune cell membranes NLRP3 KMO PMC7178465__F3 Increase of intracellular calcium activates neural nitric oxide synthase (nNOS), causing increased NO levels KMO NDUFA9 SIRT3 PMC8197470__F1 Advantages and Disadvantages of Different Treatment Methods in Achondroplasia: A Review FGFR3 CNP PTH PMC10796102__F6 Action of cerebral lymphatic system in brain diseases due to impaired renal function TH DUSP5 AHR DUSP16 UNK DUSP8 PMC10796102__F4 Binding of CCL19/CCL21 to CCR7 activated signaling pathways in tumor cells, including PI3/Akt, MAPK/ERK and Jak/STAT, which enhanced the expression of VEGF-C and thus promoted lymphangiogenesis VEGFC CCL21 CCR7 CCL19 CD80 PMC10796102__F5 Communication between the gastrointestinal tract and cerebral lymphatic system is mediated directly and indirectly by immune, neural and endocrine pathways CORT NLRP3 AQP4 PMC10796102__F3 Possible mechanisms of co-occurring neuroinflammatory response and brain edema in patients with hepatic encephalopathy and potential therapeutic targets for hepatic encephalopathy VEGFC AQP4 TNF PMC7123501__F3 Simplified scenario model illustrating the intrinsic and extrinsic apoptotic pathways CASP3 RIPK1 TRADD CASP9 DES TNF TRAF2 CASP8 FADD BAX PMC7123501__F4 Simplified scenario model of the necroptotic pathway HMGB1 CXCL1 RIPK1 TLR4 TRADD IL33 RIPK3 TNF TRAF2 IL1B TLR3 MLKL PMC3904234__F1 Interleukin-17 (IL-17) and IL-17 receptor family members and their biological roles TRAF5 TRAF6 IL17RB TRAF2 IL17RC PMC8535311__F2 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis APC GSK3B CCND1 PMC6617489__F5 Lipotoxicity of VLDLs on mediating maladaptation of calcium regulation to derangement of sarcomere proteins in atrial myopathy VLDLR ORAI1 STIM1 PMC8535311__F3 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis SMAD2 SMURF2 SMAD4 SMURF1 TGFBI PMC4380664__F3 Pharmacological targets and signaling cascades proposed to be important in mediating synaptic plasticity underlying extinction REM2 GC SRC RHO BDNF PMC6061795__F8 An Orc1-2-centered network of DNA damage response in S TBP ORC6 RAD50 ORC1L MRE11A ORC3 ORC2 PMC7251178__F1 TGFB and BMP-7 pathways SMAD2 SMAD4 BMP7 RHO SMAD1 DKFZp781O1323 PMC7251178__F2 Inflammasome complex -dependent and -independent pathways involved in EMT NLRP3 IL18 SMAD2 SMAD4 MYD88 PMC6365421__F1 Chaperone mediated autophagy mechanism GFAP RAC1 PHLPP1 PMC6524193__F5 Functional prediction of key lncRNA-mRNAs network NOTCH2 ENO3 HLA-G MAPK9 ELOC ADAMTSL4 COA1 NOTUM DCAKD MTHFD1 GCNT1 FUS TUFM HPS3 MUC6 NR1C2 ADPGK ST3GAL1 B4GALT1 PMC4081729__F5 Modification of the Nrf-2 and NFKB signaling pathways by phytochemicals upregulates antioxidant and detoxification enzymes and suppresses inflammation MAF KEAP1 BCL2 PMC3171706__F3 G2/M transition and G2/M checkpoint induction PLK1 WEE1 ATM MDM2 CDC2 ATR C13orf34 MYT1 PMC8250230__F5 An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS‐CoV‐2 Main Protease CXCL8 CFP IL6 CCL2 ACE2 IL1B CCL3 PMC3171706__F1 G1/S transition and G1/S checkpoint induction MCM7 CDC45 MCM3 MCM5 MCM6 MCM2 CDC6 ATM CDK2 MDM2 ORC1L CDK4 CDT1 PMC2915738__F7 Metalloproteinase-dependent cross-talk between the PDGFRB and the EGFR/ERK1/2 signaling pathway EGFR ADAM17 PMC8346230__F5 Representative diagram of the molecular interactions among AJUBA, CDH4, and CTNNB1 CDH4 AJUBA PMC8317057__F4 Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion? STAT2 CCND1 NUP98 IRF3 TYK2 CCL2 MYD88 SP1 TRIM25 TLR3 STAT3 PMC3995130__F2 mTOR Signaling in Cardiac Physiology and Disease TSC2 TSC1 DEPTOR RHEB PMC9050958__F8 Interferon-gamma Induces Melanogenesis Via Post-Translational Regulation of Tyrosinase STAT1 DCT KITLG TYRP1 IFNGR2 MC1R JAK1 IFNGR1 IFNG PMC3131090__F1 Negative regulation of the autophagy pathway ULK1 ATG12 ATG3 MTOR PMC5139348__F3 PI3K Pathway in B Cell Metabolism BACH2 SYK PTEN HVCN1 PMC5139348__F1 PI3K Pathway in B Cell Metabolism TSC2 TSC1 BCR CD40 PTEN ACLY FOXO1 HK2 PMC5139348__F2 PI3K Pathway in B Cell Metabolism ACLY HEL-S-133P PMC5753586__F2 Non-canonical NFKB pathway in immunity and inflammation TBK1 OTUD7B NLRP12 TRAF3 RELB TNF TRAF2 PMC5753586__F3 Non-canonical NFKB pathway in immunity and inflammation BCR GC CXCR5 CD40 ICOS PMC11871115__F7 Mechanism of action of polyphenols in Alzheimer's disease (AD) through modulation of the WBC signaling pathway APC DKK1 PMC8360640__F2 Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma HGF NGF NGFR CXCR4 MMP9 ADRB2 CXCL12 STAT3 PMC11695688__F9 Simple signaling pathway diagram ZMAT3 ITGB1 PMC3069928__F1 Biological actions of IGF-1 are mediated by IGF-1R and modulated by IGFBPs IGF1 IGF2 IRS1 PMC2386284__F5 The mechanism of retinoic acid stimulation of NIS expression by modifying signal transduction pathways in breast cancer and thyroid cells, based on the results of the inhibitor studies IGF1 RAC1 IRS1 PAX8 PMC8126715__F1 KRAS-Mutant Non-Small Cell Lung Cancer: An Emerging Promisingly Treatable Subgroup GRB2 STK11 ARHA CDK4 MTOR CDK6 CDC42 PMC5007117__F2 Schematic representing intrinsic and extrinsic apoptosis initiation APAF1 MCL1 BAX PMC8979796__F4 Metabolic pathways regulating the development and non-genomic heritable traits of germ cells SHMT1 HEL-S-51e PMC8576268__F1 Deciphering glial scar after spinal cord injury USP21 TNF FADD PMC8891573__F1 Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance HEL-S-277 AGXT2 PMC6250734__F8 Diagrammatic sketch of molecular mechanism APC PMC8102268__F4 Study of the differential expression profiles of Keshan disease lncRNA/mRNA genes based on RNA-seq NLK CDR2 ATM FRK INS SMAD4 KLF2 PTEN SKP2 PMC3938550__F5 Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines PIK3CD RELN VWF SRC ARHA DOCK1 PMC3407377__F3 TGFB signaling via TAK1 pathway: Role in kidney fibrosis SMAD2 ATF2 SMAD4 MAP3K7IP1 PMC3407377__F2 TGFB signaling via TAK1 pathway: Role in kidney fibrosis ATF2 TRAF6 MAP3K7IP1 PMC6165716__F8 Schematic showing PDK4 as a checkpoint in NFKB/TNF-mediated apoptosis CASP3 CASP9 PDK4 TNF PMC8566352__F2 Plasmalogens and Chronic Inflammatory Diseases FAR1 HEL-S-5 PMC3912139__F6 GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes MUC5AC GNAS MUC2 PMC2193446__F7 The hypothesized biochemical pathway responsible for the hyperproliferative phenotype of Nf1 +/− mast cells in response to SCF PI3 PAK1 PMC8514721__F1 Microbiota and Colorectal Cancer: From Gut to Bedside IL18 STAT3 PMC4570227__F4 Metabolic pathways with compounds that can be used as molecular imaging probes for HP MRI CS PC HP FH DCT GLS PMC4498995__F2 Metabolism and transport of acetaminophen in the liver at highly toxic doses UGT1A3 ABCC3 UGT1A9 SULT2A1 GSTM1 CYP1A2 CYP2E1 UGT2B15 HEL-S-22 GSTT1 SULT1A1 ABCG2 ABCC2 UGT1A1 PMC4367189__F2 Signal transduction pathways from the cell membrane to the nucleus discussed in this article RUNX2 SKI SP1 MTOR SP3 FOXH1 PMC6466611__F6 Cyclin C-Cdk8/19/3 inhibit the Notch pathway by phosphorylating the Notch intracellular fragment (NICD) and promoting its degradation in leukemic T cells CDK19 CDK3 CDK8 CCNC PMC4448604__F2 Drosophila Hippo pathway ZYX APP SCRIB WBP2 PMC8443079__F2 Regulation of renin in the collecting ducts COX2 REN AVP AQP2 PMC5289082__F5 Toll-like receptor-mediated actions TRAF3 TRAF6 IRF3 MYD88 PMC7708378__F4 GHR activation and signaling HLA-G LYN IRS1 PMC8021480__F1 Schematics of GSC niches and the redox signaling at play FGF2 GSC TF PMC7969799__F1 The molecular mechanism of TRP channel-mediated pathogenesis of neurological disorders: (A) Alzheimer’s disease, (B) Parkinson’s disease, (C) Huntington’s disease, (D) Amyotrophic lateral sclerosis, and (E) epilepsy TRPC7 TRPC4 PI3 TRPC1 TRPV4 TRPC5 MTOR BDNF TRPM7 TRPV1 CPZ PMC7413060__F1 Innate immunity in the initial phase of infection NLRP3 TLR7 SIGLEC14 IL1B PMC12122306__F1 Insulin signaling pathway in cardiovascular changes in GDM MTOR IRS1 PMC4982242__F1 Non-activated canonical Wnt signaling pathway and the drug targeted components APC LRP5 LRP6 TNKS PMC4982242__F2 Activated canonical Wnt signaling pathway and the drug targeted components SFRP4 LRP5 LRP6 PORCN DKK1 PMC5662193__F6 Cytotoxic Vibrio T3SS1 Rewires Host Gene Expression to Subvert Cell Death Signaling and Activate Cell Survival Networks IL21R THBD CXCL8 KIF1C ZNF100 HSPB8 CCL2 ZFP36 REST CSF2 TNLG5A BHLHB2 FOS CDKN1B ATF3 DUSP10 INSIG1 TWIST1 KLF4 KLF2 AMIGO2 CXCL1 CSF3 RCAN1 CEBPB BMP4 CEBPD IER3 F3 SGK1 JUN KLF6 PLK2 EGR1 TSC22D3 PTGS2 LIF SMAD6 KLF5 CXCL2 STC1 IL6 FGF18 BCL2L2 NFKBIA GIG8 NR4A3 PMAIP1 NFIL3 JUND IKZF2 SOCS1 PMC3628101__F1 The novel NRP2A6B1-FAK-RAS-GLI1 axis involved in the regulation of tumour initiating cells in breast cancer BMI1 NRP2 PMC5483433__F2 The potential roles of miR-M4-5p and miR-K12-11 in regulating the TGFB signaling pathway and promoting tumorigenesis SMAD2 LTBP1 TGFB1 DKFZp781O1323 PMC2565686__F6 Merger of the interaction maps for the three human proteins ING1, MEKK, and p38a (p38MAPK) based on empirical data retrieved from the STRING database CSNK2A2 RBBP4 HEL-S-1 ATF2 RPS6KA4 MYC ATF1 CREB1 RB1 MAP2K6 STAT1 FYN ANXA2 MAPKAPK5 PTK2B HDAC2 SIN3A SP1 DYRK1B MAPKAPK2 DUSP4 ING1 FOS GADD45A CDC25B TNF KRT18 YWHAQ MAPK13 DUSP10 MAX TRAF1 DMAP1 RBBP7 DUSP16 AXIN1 GRB2 DUSP2 MAPK11 DIXDC1 CSNK2B MEF2C DUSP7 MYOD1 PCNA CD36 CDC42 PML HEL2 MAP2K4 RUNX2 BRMS1 MAP2K3 MX1 GADD45B GZMA PTPN11 PTPN6 YWHAG IL1B JUN SAP30 NCOR2 GATA3 GADD45G GMFB RAC1 DDIT3 HDAC1 CASP3 MRGBP CREBBP EP300 BUB1B PLA2G1B RELA ZAP70 CD40 HEL-S-93 PMC8699889__F10 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer BAD ATM CXCR4 ATR PARL PMC11274491__F7 Proposed scheme for the anti-angiogenic activities of PZ-DHA GSK3B RHO PTEN MTOR CCND3 CDC42 PMC8699889__F11 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer CDC20 RASSF1 PLK1 NR3A2 ATM CDK2 APC CDC2 IL4 ATR SKP2 PMC8699889__F12 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer SPR TH BCR HEL-S-11 RHO LAT PMC7197128__F6 FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and Beta-catenin activity in ovarian cancer E2F5 CCND1 FAT4 PMC7427672__F1 OI genes involved in collagen biosynthesis and maintenance of bone homeostasis SPARC BMP1 WNT1 P3H1 TENT5A COL1A1 PAH TMEM38B PLOD2 MESD CRTAP MBTPS2 COL1A2 PPIB SP7 IFITM5 PMC8125483__F1 Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models NLRP3 CARD9 IL18 IL16 CD82 RELB SYK RAF1 IFNG PMC5680920__F8 Schematic representation of the regulatory mechanism about PLOD2 was summarized EGF FOXA1 EGFR TGFA PLOD2 PMC5010449__F3 Avoidance and subversion of eukaryotic homeostatic autophagy mechanisms by bacterial pathogens ULK1 DKFZp686F0183 PMC12226309__F1 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products TBK1 CGAS IRF3 PMC2719424__F8 DUOX1 involvement in TLR-mediated IL-8 production in response to bacterial stimuli DUOX1 EGFR CXCL8 SRC TGFA ADAM17 PMC12226309__F3 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products CGAS AHR MITA PMC12226309__F4 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products NLRP3 CGAS IRF3 BAX PMC9163066__F8 Schematic model for the circSCAF8-miR-140-3p/miR-335-LIF pathway LIF STAT3 PMC8395722__F2 Synthetic mRNAs; Their Analogue Caps and Contribution to Disease TSC2 TSC1 MDM2 BCL2 PMC9008121__F2 Targeting non-coding RNAs to overcome cancer therapy resistance AGO2 SLC7A11 YBX1 CXCL10 GATA6 ATG2A PTEN COMP TOP2A AXL PRKDC AURKB PMC6351746__F1 Biochemical pathways of R HEL-S-62p HAMP MCL1 PMC8648605__F6 Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma RAB27A PMC6476693__F1 Metabolic profiles influence macrophage inflammatory status NR1C1 STAT3 CD36 PMC12118952__F3 LDH in the occurrence and development of liver cancer HEL-S-281 PMC7085230__F7 Mechanisms for the inhibition of SMAD2/SMAD3 and the activation of TET1 signaling by MSTN mutation MYF5 SMAD4 MSTN MYOG PMC5352210__F5 Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism ATF4 EGFR ATF3 PMC7456869__F4 SARS-CoV-2 in the RAAS pathway MRGPRX2 ATR ACE2 PMC7456869__F5 SARS-CoV-2 in the complement system HEL-S-62p C4B_2 PMC8965836__F9 Parathyroid Hormone Promotes Human Umbilical Vein Endothelial Cell Migration and Proliferation Through Orai1-Mediated Calcium Signaling NFATC1 PTH COL1A1 ORAI1 STIM1 PMC7456869__F6 SARS-CoV-2 in coagulation PLG ACE2 PMC3081520__F2 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease LAMP2 ALG12 MTOR ATG14 DKFZp686F0183 PMC5653461__F1 Progesterone Receptors (PR) Mediate STAT Actions: PR and Prolactin Receptor Signaling Crosstalk in Breast Cancer Models WNT1 PRLR PMC3081520__F4 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease ATG12 ATG14 DKFZp686F0183 FADD PMC8943211__F7 Monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells LPA TG MGAT2 PMC5041017__F1 IFN signalling pathways induced by IFNA/B and IFNG (see text for details) STAT1 STAT2 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 PMC4915141__F7 The biologic role of TRIM11 in lung cancer TRIM11 CCND1 PCNA PMC5593690__F1 PI3K/Akt pathway: a critical player in intervertebral disc degeneration BAD GSK3B CCND1 PTEN EIF4E DEPTOR RHEB BAX PMC5593690__F2 The PI3K/Akt pathway: a critical player in intervertebral disc degeneration GSK3B IVD CCND1 MTOR SOX9 PMC8620733__F9 CDK4 in the Pathogenesis of Pancreatic Cancer BAD POLK BRCA2 CASP9 RAD51 CDK4 JAK1 PALM3 STAT3 PMC8122967__F1 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks PDGFRA TRADD MAPK3 BCL2L1 PTEN RNF146 PARG MAP2K6 PARP16 BIRC2 VEGFC WEE1 APAF1 GPX2 BIRC3 GRB2 CCND1 BCL2 TRAF2 SIRT1 FADD RBL2 MAFG PMC8122967__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks RIF1 SSB XPC DDB2 PARG MRE11A BRCA1 PARP3 APLF FEN1 ATM BRCA2 RAD51 XPA NOP10 PMC8122967__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks PARP14 ME1 ULK1 PARP10 VHL PARP1 TNKS PTEN PARG MTOR TNKS2 RHEB HEL-S-162eP TSC2 HEL-S-26 RICTOR TSC1 PARP2 HEL-S-133P SIRT1 HK2 GLS FASN MAFG PMC3057977__F3 Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis CDC20 CS APC RCC1 HCTP4 CDC2 RAN NUMA1 PMC1186689__F1 Interferon-Gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes COX2 ATF2 JAK1 IFNG PMC8620733__F8 CDK4 in the Pathogenesis of Pancreatic Cancer CD14 ORC6 CD6 GSK3B SMAD4 MCM7 STAG1 DBF4 CDK7 STAG2 ORC2 SMC3 CDK2 FREP1 MDM2 PCNA SKP2 PMC7045041__F1 Possible central and peripheral effects of asprosin TLR4 AgRP FBN1 PMC7911844__F2 Biosynthetic pathway of the mcm5s2U modification URM1 PMC4601503__F3 Binding proteins PTEN MTOR PMC2988681__F2 Programming anoikis induction GSK3B SRC FADD PMC6640697__F13 In vivo safety evaluations of MOv18 IgE MAPK3 PTK2B SYK PTPN6 B2M ITGB1 PMC5048206__F2 Schematic depicting the major proinflammatory glial-mediated changes to inhibitory synapses within the spinal dorsal horn that facilitate central sensitization CCL2 TNF IL1B IFNG PMC8053610__F7 The underlying mechanism of calycosin effects on signaling pathways and the induction of apoptosis in GC cells BAD CDK2 CDK4 CDK6 PMC8092118__F3 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent NOTCH2 MAML1 NOTCH4 RBPJ DLL4 MMP9 NOTCH1 CCND1 FURIN DLL3 HIF1A NOTCH3 PMC8092118__F1 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent ZNRF3 RNF43 APC LRP5 CD44 LRP6 BMI1 GPR49 MAP3K7IP1 LGR6 NLK LEF1 CYLD ABCG2 ABCB1 BCL9 WLS PMC2756491__F8 PPARA/p16INK4a Pathway inhibits Vascular Smooth Muscle Cell Proliferation by repressing Cell Cycle-dependent Telomerase Activation CDK4 NR1C1 CDK6 TERT PMC4047132__F2 Cellular functions of proteins commonly mutated in uveal melanoma ASXL1 BRCA1 BAP1 PMC5595793__F1 Schematics of alcohol production via the iterative ketoacid elongation HEL-S-62p C7 C6 PMC4477219__F2 Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence KEAP1 SIRT1 PMC8586683__F6 Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth GSK3B CCL21 CCR7 PMC4073609__F2 By activating Sirt1, NAD+ conjoins two feedback loops necessary for cross-talk between the circadian clock and metabolite production NAMPT NMNAT1 NMNAT2 NMNAT3 SIRT1 PMC9529885__F7 Diesel exhaust particles induce human umbilical vein endothelial cells apoptosis by accumulation of autophagosomes and caspase-8 activation STX7 STX17 VAMP8 SNAP29 YKT6 PMC6850919__F8 Resveratrol (Res)‐mediated suppression of ALI through STAT3/SOCS3 signalling SOCS3 SIRT1 STAT3 PMC9426234__F1 HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways HK3 HK2 PMC8508942__F2 Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis MRTFB EGF SMAD2 MYOCD KLF4 RHO mkl1 PMC7076804__F5 Cross-talk between activation of the DDR and the IR upon infection with genotoxin-producing bacteria IL10 ATM IL9 IL13 IL24 IL6 IL1B PMC3080846__F1 Innate Immune Sensing of DNA TLR9 TRAF3 TREX1 MYD88 AIM2 MAVS PMC8431111__F10 circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway AGO2 MAPK7 BTBD7 PMC3246677__F2 Regulation of viperin expression TLR4 IRF7 RIGI IRF3 IRF-1 TLR3 MAVS PMC8904240__F7 Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway BCL2 ATG14 DKFZp686F0183 PIK3R4 PMC2911411__F3 Network analysis of BAL proteome changes under baseline conditions AFP MYH4 HBB ELANE PMC6603210__F1 IL-1F family signaling complexes IL36A IL33 IL36B IL1R1 MYD88 IL18BP PMC8733588__F2 What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy? CCL2 LAG3 CCL3 PMC7031046__F6 Identification of cancer driver genes based on nucleotide context ZFHX3 BRAF RPL22 CTCF EGFR NRAS ARID2 SMAD4 PTEN RHO MYD88 RB1 MTOR POR CDKN2A ARHGAP35 FBXW7 FGFR2 HEL-S-26 PIM1 POLE ATM NF2 FLG B2M BAP1 ME1 KIT APC PIR VHL FGFR3 TNF HRAS STAG2 HLA-A BCOR CARD11 KMT2A EP300 PIK3CA ERCC2 SETD2 MLL2 PMC3360100__F3 Examples of signal transduction pathways in astroglial cells following P2Y1R activation CASP3 CASP9 GDNF STAT3 PMC3360100__F2 Examples of signal transduction pathways in astroglial cells following P2X7R activation IL16 RHO PANX1 PMC5125043__F1 The inflammatory response to extracorporeal membrane oxygenation (ECMO) HEL-S-62p C9 C7 C6 IL1B PMC4092924__F2 Schematic illustration of the current working hypothesis on IFNT signaling in ovine uterine stroma and uterine glandular epithelium compared to uterine luminal (LE) and supferficial glandular (sGE) epithelia STAT2 CXCL10 STAT1 ISG15 SLC7A2 HEL-S-2 IGFBP1 GBP2 TYK2 B2M IRF-1 IRF2 AK1 PMC4092924__F3 Proposed model of IFNT signal transduction cascades that is independent of STAT1 in the ovine uterine LE and sGE HEL-S-2 MAPK3 RPS6 MTOR IRF2 IRF-1 AK1 PMC3495805__F1 Functional roles of pluripotency transcription factors in mesenchymal stem cells BMP4 PMC3133882__F4 Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment APC GSK3B LPA PMC9033251__F1 How compensatory mechanisms and adaptive rewiring have shaped our understanding of therapeutic resistance in cancer EGFR EIF4E MTOR IRS1 CDK6 RHEB INSR TSC2 RICTOR TSC1 CDK4 GRB10 EIF4B PMC11396105__F11 Schematic diagram reveals key genes and pathways involved in the heterosis formation of EFT SLC27A4 ITGB3 FOXF2 SLC27A2 ACACA VEGFA IGFBP7 FGF12 IGFBP5 BAAT G0S2 DGAT1 APOB MEGF8 ITGB4 POMC FADS2 APOF ACACB IGFBP4 SLC27A1 PMC8328821__F3 NUMB/NUMB isoforms in cancer stem cells NUMB BAD TSC1 JAG2 MDM2 GADD45A ADAM10 PTEN CDK8 ADAM17 HES1 PMC8105388__F3 Transcriptome of wild-type and immortalized corneal epithelial cells ANAPC13 ANAPC7 E2F4 CDC23 ORC6 APC SMAD4 MCM7 STAG1 COCH CDK7 STAG2 CDC45 ORC2 MCM3 CDC20 SMC3 CDK2 MDM2 ATR SKP2 PMC11396105__F10 Interaction network of lipid metabolism-associated pathways and key genes MAPK9 DGAT2 IGFBP7 ACOT4 CPT2 ACSS2 IGFBP5 BAAT DGAT1 MEGF8 POMC ITGA6 ACACB PIK3CA FABP1 CD36 PMC4122637__F3 PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics SLC22A13 SLC17A1 SLC17A3 LGALS9 SLC22A11 SLC2A9 SLC22A6 ABCG2 PMC4400837__F2 RAS trafficking pathway ICMT RCE1 CSA2 PMC5872601__F1 The signalling pathways of UPR ATF4 EIF2A XBP1 PMC9255486__F3 Mitochondria: intracellular sentinels of infections CGAS IRF3 ATF5 MAVS CLPP BAX PMC6073339__F2A Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells PDK4 NR1C1 UCP2 PMC11779860__F6 Mechanistic diagram of HF against HAPH SMAD2 CCND1 PCNA CDK6 PMC5448185__F1 The role of ITSN1 in Reelin signaling in the forebrain VLDLR ITSN1 DAB1 APOE PMC7982600__F1 Known signaling pathways involved in FGF21 expression from skeletal muscle TSC2 FGF21 EIF2A MYOD1 PMC5833071__F7 CXCL12 stimulates expression of connective tissue growth factor CXCR4 RAC1 CXCL12 PMC5114407__F7 Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1 CDK2 CCND1 CDK4 CDK6 CCNE1 PMC6322655__F1 Immune responses of macrophages and dendritic cells regulated by mTOR signaling TSC2 TSC1 IGF1 PTEN RHEB PMC9471422__F2 Contribution of the gut-liver axis to the immune signaling pathway of NAFLD IL10 CD14 PROX1 MYD88 NR1C1 FOXO1 CYP7A1 NLRP3 RAB1A TLR4 LBP FGF19 SIRT1 PMC6885373__F1 DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency SMARCD3 MYC GMNN PMC4865369__F7 Model for wntP-2, ptk7 and ndl-3 in control of patterning ND3 ND1 ND2 FZD2 PTK7 FZD7 FZD1 PMC6073339__F1A Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells CPT1A CPT1C CCND1 SRC KLF2 NR1C1 NR1D1 PMC9368912__F2 Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico CCND1 PTEN AXIN2 PMC2413267__F1 Wnt Signaling and Skeletal Development APC LRP5 LRP6 PMC9048904__F6 Thirty years of resistance: Zig-zag through the plant immune system FER CAMTA2 UPF2 CAMTA1 PMC6663587__F7 Signaling cascade in RANKL-RANK induced osteoclastogenesis: A model of IRF8-mediated regulation of osteoclast differentiation MAFB NFATC2 CTSK IRF8 NFATC1 OSCAR DCSTAMP TRAF6 ACP5 CALCR JUNB BCL6 PMC2430594__F1 Cartoon of two of the most promising DNA repair pathways for cancer therapeutics ATM ATR PCNA MPG PMC10921469__F9 TRPM4 and TRPM5 mediate Na+ influx upon stimulation with bitter compounds and carbachol (acetylcholine) in parietal cells from the cell line HGT-1 as major signaling pathway TRPM5 PMC8616751__F2 Therapeutic targeting opportunities in cancer cases with RSPO overactivation ZNRF3 RNF43 APC LRP5 LRP6 PORCN GPR49 LGR6 PMC8616751__F1 Canonical Wnt pathway and the potentiating effect of RSPO ZNRF3 RNF43 APC LRP5 LRP6 GPR49 LGR6 JUN PMC2952500__F1 Schematic diagram showing the results of ras activation by Grb2 EGF PI3 GRB2 GATA6 PCNA PMC6589336__F2 Synthetic Biology Tools for Programming Cell and Tissue CD19 TET1 PMC4232466__F2 Inflammophilic character of the periodontitis-associated microbiota C6 ARHA MYD88 TLR1 SMURF1 MAL PMC4237952__F4 Complement-induced inflammation pathway: an important mediator of neuroinflammatory processes from M4 onwards HEL-S-62p ITGAM ITGB3 C4B_2 ITGAX C1QC PMC4314091__F1 Unusual Case of Porcupine RNF43 APC TEF LRP5 LRP6 PMC6326012__F1 The metabolic pathway for vitamin D (Adapted/modified from Schlingmann et al FGF23 CYP2R1 CYP24A1 PTH CYP27B1 PMC3574275__F1 Structural and functional characteristics of the human CD38 molecule BCR CXCR4 TRPM2 CD81 CD19 PMC5888214__F4 The SREBP pathway regulates cellular cholesterol metabolism NPC1 INSIG1 LDLR HMGCR PMC9155920__F2 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling NLRP3 KEAP1 MYD88 NQO1 PMC4841706__F5 Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases NRF1 CCNB1 CCND1 CDK4 CDC2 CCND3 PMC9155920__F3 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling KEAP1 GSK3B PMC7189101__F10 Proposed model showing the connecting link between AKT and MASTL signaling during mitosis ENSA CDC2 MASTL PMC6372796__F9 Proposed model of IFN and inflammasome activation by HCMV and IL-1B inhibition by IE86 STAT1 CGAS IL16 STAT2 IRF3 IFNAR2 MIP IFNAR1 AIM2 GSDMD PMC9005190__F3 Receptor-specific signaling signatures LPA POR PMC5879765__F4 Osteogenic differentiation through p38 MAPK signaling pathway RUNX2 EBP BMP2 NPS RAC1 OSM PMC8621500__F7 Global Analysis of Transcriptome and Translatome Revealed That Coordinated WNT and FGF Regulate the Carapacial Ridge Development of Chinese Soft-Shell Turtle NLK DAAM1 INVS SIAH1 APC SOST CER1 SKP1 ARHA PMC8627637__F1 Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration FYN KEAP1 GSK3B PMC6513188__F8 Schematic diagram for the inhibitory mechanism of CYC116 in mast cell activation PLCG1 FYN SYK LAT PMC8291708__F1 De novo purine synthesis (DNPS) pathway ADSL PAICS APRT PMC3722362__F3 Regulation of Iron Absorption in Hemoglobinopathies EPO HAMP GDF15 SMAD4 HFE CEBPA B2M TFR2 STAT3 PMC4937730__F1 Human polyamine biosynthesis, metabolism and transport and the methionine salvage pathway MTAP SRM SLC3A2 AMD1 SMS PMC5296245__F2 Restoring sAPPA functions as a potential treatment for Alzheimer’s disease BACE1 IGF2 ADAM10 PMC3836673__F1 Intracellular effects of estrogen are exerted through two main pathways, genomic and non-genomic SOST GRB2 SRC SP1 TF PMC9048097__F9 Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/Beta-catenin/MDR1 signaling axis by upregulating miR-384 PTN ALK APC GSK3B PMC3338341__F1 Repressed (left) and activated (right) canonical HH signaling pathways DHH IHH GLI3 GSK3B SHH CCND1 BCL2 SMO CCND2 PMC3338341__F2 Mechanisms of activation of HH signaling in hematological cancers DHH IHH ALK GSK3B SHH CCND1 BCL2 SMO ABCG2 CCND2 PMC3288889__F5 Ephrin-B cleavage and signaling CSK SRC PMC4026305__F1 Nox NADPH Oxidases and the Endoplasmic Reticulum ATF4 EIF2A NOX4 XBP1 PMC9130907__F1 Hemostasis and tumor immunity REN TF PMC3219632__F11 Suppressor of Cytokine Signalling-6 Promotes Neurite Outgrowth via JAK2/STAT5-Mediated Signalling Pathway, Involving Negative Feedback Inhibition IGF1 SOCS6 PMC12109684__F7 Schematic diagram illustrating the proposed mechanism by which AHE-EA-C exerts its anti-leukemic effects in AML cells CCND1 CDK4 BAX PMC6946788__F2 Decorin and biglycan participate in multiple signaling pathways of innate and adaptive immune responses NLRP3 EPO MYD88 TGFB1 IL1B PMC5489557__F7 Mechanism for PE’s effects on hepatocellular carcinoma cells ATF4 EIF2A PMC6430464__F9 Proposed model depicting the possible mechanism of XIST on mediating cell proliferation, viability and apoptosis via generating a negative feedback regulation of NF‐KB/NLRP3 inflammasome pathway NLRP3 IL1B PMC3255271__F1 Study schema STAT1 SET ABCG2 STAT3 PMC6350112__F1 COMMD7 Regulates NFKB Signaling Pathway in Hepatocellular Carcinoma Stem-like Cells HNF4A COMMD7 COMMD1 PMC5746469__F3 Initiation of oocyte and follicular growth TSC2 RPS6KB1 PI3 TSC1 PTEN EIF4EBP1 MTOR PMC5994511__F2 Summary of the speculative roles of UNC5C in AD pathogenesis PMC5896264__F1 Central C metabolic network of Brucella (adapted from ) CIT TNLG7C HEL107 RPE MAL HEL-S-162eP PMC8207419__F5 Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction TBK1 IRF7 IRF3 IRF-1 PMC4106657__F4 Cancer driver genes and pathways CREBBP IRS4 BRAF NTRK1 ZNF274 NTRK3 BCL2 ARHA PTEN OCRL SH2B1 PMC3031497__F7 Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer UBE2C VAPB RAE1 TOMM34 RPS21 PMC9321618__F3 Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms KEAP1 NQO1 PMC5097897__F4 Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling CD47 EGFR CD44 PMC7396672__F6 C1EIP as an activator of ENO1 to promote chicken PGC formation via inhibition of the Notch signaling pathway SOX2 DAZL ENO1 STAT3 PMC4586789__F3 Inhibitors of the Hh signaling pathway target different Hh signaling components DHH IHH SUFU SHH SMO PMC8363310__F3 Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections RICTOR AMOTL2 MYC CD44 LATS1 PTEN RAC1 MTOR LATS2 SGK1 MLST8 PMC4647710__F2 Canonical and noncanonical NFKB signaling pathways BCR RELA CD40 LTBR PMC8392837__F1 46,XX DSD: Developmental, Clinical and Genetic Aspects CYP11A1 HSD3B2 POR CYP17A1 CYP21A2 STAR CYP11B2 PMC4502937__F8 Schematic representation of the molecular interactions following macrophage and cancer cell activation CCR2 CSF1R TLR4 TWIST1 PMC7756641__F4 Adaptogens on adaptive stress response intracellular signaling pathways (updated from authors’ drawings) CD14 FOS PMC11682995__F4 Selected signaling pathways regulated by AKR1B10 AKR1B10 PMC8157222__F1 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals RGS4 VHL ATE1 UBR1 HIF1A PMC8157222__F2 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals VIT ATE1 ERF UBR1 RFWD2 PMC6475831__F2 Regulation of intestinal organoid formation by different growth factors EGF WNT3A STAT3 PMC4159398__F2 Membrane receptors and intracellular signaling pathways activated by IL-4 and/or IL-13 IL13RA2 JAK3 JAK1 PMC8750478__F9 Adipose-Specific PPARA Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue SCARB1 ABCG1 SOAT1 ABCA1 NR1C1 PMC7655096__F2 Major signaling pathways during the process of osteoclast differentiation BTK NFATC1 GRB2 OSCAR TEC SYK SIRPB1 PMC6400107__F5A Laser Microdissection-Based Tissue-Specific Transcriptome Analysis Reveals a Novel Regulatory Network of Genes Involved in Heat-Induced Grain Chalk in Rice Endosperm MYB MSC ERF PMC8039187__F7 Findings in the study ND6 ND2 FH POLG2 POLG ND4 TFAM SSBP1 PMC4995293__F5 Extracellular pH‐sensitive ion channels in the PNS KCNQ2 KCNQ3 TRPV1 PMC6580174__F9 Ingenuity Pathway Analysis Molecule Activity Predictor algorithm indicated that loss of nuclear matrix protein 4 (Nmp4) elevates protein folding and attenuates endoplasmic reticulum (ER) stress-induced apoptosis HSPA14 OS9 MAPK8 HSPA2 HEL-S-99n PRKCSH SYVN1 XBP1 AMFR TRAM1 ATF4 UBE4B SEC61A1 UGGT1 UBXN1 SEL1L MAN1B1 SVIP MAP3K5 HEL117 YOD1 DDIT3 DERL1 CANX INSIG1 PLAA EDEM1 HEL-S-269 NPLOC4 NGLY1 BCL2 VCP TRAF2 PMC9675361__F1 DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study ATM BRCA2 RAD50 RAD52 RAD51 XRCC3 MRE11A PMC9270569__F1 Cardiovascular Disease in Duchenne Muscular Dystrophy PLN MCU RYR2 PMC5546706__F4 Reconstructing the regulatory circuit of cell fate determination in yeast mating response HEL-S-62p FAR1 C6 PMC8642693__F9 Gentiopicroside promotes the osteogenesis of bone mesenchymal stem cells by modulation of B‐catenin‐BMP2 signalling pathway RUNX2 BMP2 SMAD1 DKFZp781O1323 PMC9687157__F2 MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity ADIPOR1 ADIPOR2 CCR2 TLR4 CCL2 PPARG NR1C1 APPL1 PMC6056002__F1 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression NAMPT GSK3B PAK4 RHO PMC5026315__F1 Glomerular basement membrane heparan sulfate in health and disease: a regulator of local complement activation HEL-S-62p C9 MASP1 C7 C6 MASP2 C1S PMC6056002__F2 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression IL10 NAMPT PAK4 RHO RAC1 PMC9469902__F1 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy NRF EGFR CCL5 ACE2 PMC9469902__F3 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy STAT2 IRF9 TYK2 JAK1 PMC9469902__F4 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy SOCS3 GRB2 SOS1 SOCS1 STAT3 PMC3265021__F2 Signal transduction events that link ER stress to inflammation ELF2 ATF4 TRAF2 PMC8877887__F2 THAB Immunological Pathway as Protective Immune Response against Prion Diseases: An Insight for Prion Infection Therapy IL10 STAT1 PDC STAT2 IL-21 PMC3925795__F1 Simplified schematic of macroautophagy in mammals LRRK2 BNIP3 MTOR PMC7595669__F7 Lipid metabolic pathway analysis of the identified differential lipid species PC TG PMC409892__F2 Apoptotic and antiapoptotic signaling pathways BAD ATM MDM2 PTEN PMC4018400__F4 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response TBK1 TLR5 TLR9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 FADD PMC6754541__F3 Genome-based metabolic model for cable bacteria with emphasis on electron flow and energy conservation during oxygen and nitrate-dependent sulfide oxidation NONO DCT CYB PMC4018400__F5 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response ITK FYN BCL10 CD46 LCK GRB2 CDK4 CTLA4 LAT ICOS CBL PMC5341015__F6 Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis ALDOB PKLR ACO2 OTC ENO1 ARG1 ASS1 ASL MDH2 SDHB HEL-S-162eP PMC6455062__F3 All currently known proteins required for germling communication and fusion in N P1 CDC42 PMC6176282__F9 KEGG pathway suggested that various targets in p53 signaling were tightly associated with ADQ pharmacological action BAD MYC PTEN RFWD2 TSC2 CASP3 PERP ATM CDK2 RAX MDM2 CASP9 CDK4 ATR BAX PMC3361329__F2 Signaling pathways of TNFAlpha-induced hepatocyte death TRADD TRAF2 FADD ITCH BAX PMC7072595__F3 Multiple mechanisms of SFRP1 involvement in Wnt signaling pathway APC GSK3B SFRP1 PMC9305838__F3 Dual Function of Par3 in Tumorigenesis TIAM1 SOX2 APC ARHA LATS1 RAC1 SMURF1 STAT3 PMC4113109__F2 Hedgehog signalling at a glance SUFU PTCH1 SMO PMC9305838__F4 Dual Function of Par3 in Tumorigenesis TIAM1 ERBB2 RAC1 PMC10380707__F2 Inflammation, Dopaminergic Brain and Bilirubin TH DKFZp666G145 COX2 TLR4 IL13 IL6 CXCL12 HMOX1 UGT1A1 PMC5502590__F1 Diagram of major TLR pathways IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TIRAP PMC7193097__F4 Schematic model presents the effect of tea polyphenols (TP) in attenuating STS-induced cytotoxicity in hippocampal neurons STS BDNF PMC9518217__F1 Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments CD14 TLR9 IRAK2 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR7 TLR4 TRAK2 TIRAP MAL PMC8889079__F1 NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets NLRP3 MYD88 GSDMD PMC7787054__F3 Signal transduction pathways regulated by RIT1 RIT1 EGF BAD NGF RALA RALB RAC1 HIF1A IFNG RGL3 PAK1 IGF1 GRB2 CDC42 PMC7834957__F11 lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast-like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR-152-3p SFRP4 APC CCND1 PMC7862225__F2 Build-UPS and break-downs: metabolism impacts on proteostasis and aging ULK1 TFEB EEF2 EIF2A WASHC3 HSF1 XBP1 PMC8950196__F6 CDH1 Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma APC GSK3B PMC7254133__F7 Model representing the hetIL-15 triggered pathway for tumor infiltration by lymphocytes and dendritic cells XCR1 CXCR3 XCL1 IRF8 CXCL9 IFNG PMC12023894__F3 Natural compounds act on breast cancer (BC) through the Hedgehog (Hh) signaling pathway FOXM1 PTCH1 CD44 SHH NOTCH1 CCND1 SMO NOTCH3 IL1B BAX HES1 CD24 PMC6379985__F9 Schematic diagram shows the mechanism underlying cTFRC as a ceRNA for miR-107 TFRC MTOR PMC12023894__F1 Transmission of the classical Hedgehog (Hh) signaling pathway DHH PTCH2 IHH KIF7 SUFU PTCH1 GLI3 SHH SMO PMC12023894__F2 Transmission of the non-classical Hedgehog (Hh) signaling pathway EGF BAD BRAF EGFR SMAD2 TGFBR1 TGFBR2 SMAD4 PTEN RHO MTOR CCNB1 SHH SMO DHH IHH APC LRP5 LRP6 ARHA LEF1 SUFU GLI3 PTCH1 PIK3CA PMC5810418__F10 Two B-hyperpaths computed in the full NCI-PID signaling pathway APC GSK3B AXIN1 HDAC1 PMC4863690__F1 Emerging treatment options for myelofibrosis: focus on pacritinib EPO JAK1 MTOR PMC6484401__F1 Lining up for quality control: linear ubiquitin and proteotoxicity HTT SHARPIN SP1 OTULIN PMC11652534__F3 Annotated map of the target genes related to Beta-sitosterol in VR on RA-related signaling pathways BAD CD37 ATG12 INS PTEN RAC1 MTOR RHEB INSR RXRA TSC2 NLK ATM CDK2 MDM2 GRB2 FOXG1 SYK KLF2 BNIP3 SKP2 STAT3 CD19 PMC7937946__F2 NetworkAnalyst visualization of Reactome pathway “neutrophil degranulation” genes with elevated expression in individuals from Endotype A UBC TUBB4B PSEN1 IQGAP1 ELANE S100A9 RAB7A HEL-S-87p HSPA1A MME PMC8465210__F3 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity SMAD2 SMAD4 PMC9157408__F2 Is there a role for HSF1 in viral infections? MTOR HSF1 PMC11893456__F8 The main pathological changes in COVID-19 brains and related molecular pathways identified NMNAT1 MPO CX3CR1 CX3CL1 opn CD44 CASP8 PMC8268933__F3 Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis PLAT MMP11 CXCR4 CCND1 CDK4 CDK6 BAX PMC3248191__F7 Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors CXCL1 CXCL5 FGF19 FABP5 NFKBIZ MAP3K8 TNFAIP2 KRT18 HMOX1 PMC2966944__F8 Cartoon summary of expression and anatomical data, and a model for phases of A/P axis re-organization WNT1 SFRP1 PMC6279860__F2 PD-L1/PD-1 signaling pathway and the correlated network EGF LCK EGFR ZAP70 TF BATF PMC10915952__F2 Small molecule compounds inducing the osteogenic differentiation of mesenchymal stem cells RUNX2 APC LRP5 LRP6 DKK1 SMAD1 DKFZp781O1323 PMC11816792__F3 LncRNAs involved in diabetic foot ulcer healing PAQR3 TWIST1 HDAC8 KLF4 BHLHE23 EZH2 PMC9223893__F1 Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer PTGR1 GPR32 FPR2 GPR18 PMC2716493__F1 Two main pathways involved in apoptosis regulation BAD PMC10915952__F3 The crosstalk between the Wnt and bone morphogenetic protein signaling pathways in osteogenesis RUNX2 APC MSC GSK3B RHO SMAD1 DKFZp781O1323 PMC8938628__SF1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway ABO PMC6279860__F1 Targeted therapy for recurrent/metastatic head and neck cancers EGF EGFR APC VEGFA TRAF3 PTEN CTLA4 MTOR RHEB TSC2 VEGFC TSC1 TRAF5 TRAF1 GRB2 SRC VEGFB TGFA TRAF2 STAT3 PMC11816792__F2 Wounds healing by exosomes derived from adipose stem cells containing lncRNA ULK1 TLR7 PAQR3 TWIST1 FBN1 VEGFA DDR2 SOX9 STAT3 PMC11669685__F6 Schematic summary of the effect and mechanism of baicalin on H2O2-induced oxidative stress, inflammation and apoptosis in BMECs KEAP1 NQO1 BAX PMC12155367__F8 HH signaling pathway functions in the E CDK2 SMO KIF27 PCNA BAX PMC3193228__F5 Possible mechanisms of involvement of nuclear receptor LRH-1 in development of pancreatic cancer PMC8452524__F1A Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs TBK1 SOCS3 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 NOX4 IRAK4 IRF3 MYD88 TLR3 ADAM17 NLRP3 TLR8 TLR7 FURIN ACE2 TMPRSS2 MAVS STAT3 PMC1847401__F4 Genes of the insulin/IGF-2 signaling pathway are required for induced stress resistance and induced life extension SGK1 PMC4677197__F1 Canonical Wnt signalling pathway implicated in diabetic nephropathy APC GSK3B PMC6374915__F1 Different forms of programmed cell death and associated cascades FOS RIPK3 TNF ZBP1 CASP3 NLRP3 RIPK1 APAF1 CASP9 CASP8 FADD MLKL CASP5 CASP4 BAX PMC4684823__F9 Schematic summary depicting fluoride-induced oxidative damage and adaptive response ATM SIRT1 UCP2 PMC7918312__F7 Schematic illustration showing activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and how PRKAR1B-AS2 regulates it TSC2 TSC1 PTEN RPS6 PMC7379154__F2 Proposed model of skin-associated B cell functions in Alpha-gal sensitization from tick bites TLR4 TLR9 CCR6 ELL IFNG PMC5869742__F7 Inhibitors of prostaglandin synthesis in uterine fluid of pregnant mares PTGR1 ANXA1 COX1 LTB ALOX5 HEL-S-22 PMC9144962__F1 Extracellular Vesicles—A New Potential Player in the Immunology of Renal Cell Carcinoma CASP3 HLA-G CD27 TNLG8A SMAD2 SMAD4 CA9 CASP8 STAT3 PMC3645738__F4 Hypothetical time course of the unfolded protein response in mammals ATF4 EIF2A WFS1 TRAF2 PMC5869742__F5 Involvement of proteins found in the yolk sac fluid and the uterine fluid of pregnant mares in GO terms and pathways representing embryo-maternal interaction NDRG2 ACTA2 FLT4 EZR HSPD1 YBX3 ADAM17 RPS2 KHSRP ACTBL2 HMGB2 RPL3 c-fgr ACTG2 VEGFA FGFR3 CDC37 ARPC2 LIPA ARPC3 LYN ADAM10 RBMX COIL SOS1 SRGN SERPINF2 CDK9 PMC2694616__F1 Genomic Strategy to Elucidate Modules of Oncogenic Pathway Signaling Networks ATM MDM2 MTOR JUN PMC4671004__F1 BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer RICTOR PDE4A BAK1 EGFR BCL2 EIF4E MCL1 MTOR DGKA BAX PMC2696130__F3 Liquid Movement Across the Surface Epithelium of Large Airways ASL CFTR PMC2696130__F4 Liquid Movement Across the Surface Epithelium of Large Airways ASL CFTR PMC3637405__F2 Regulation of the p53-MDM2-MDMX pathway by DUBs USP4 MDM2 USP42 USP29 PMC7552962__F1 Proposed model of interactions between ion channels and Wnt signaling TRPV4 APC TRPC5 CFTR PMC6430251__F1 Schematic diagram to illustrate the activation of the nuclear factorKB (NFKB) pathway in the radiation-induced rescue effect (RIRE) BRCA2 RELA TRAF2 PMC5805701__F10 An atypical IL-6-Stat3-RFX1-IL-17A regulatory pathway in CD4+ T cells of SLE patients RFX1 IL17A ME3 HDAC1 STAT3 PMC7333668__F1 Myosin light-chain phosphatase (MLCP) through regulation of myosin phosphatase target subunit 1 (MYPT1) HEL-S-28 PAH PPIC PMC7694028__F1A BRAF Mutation in Colorectal Cancers: From Prognostic Marker to Targetable Mutation EGF BRAF EGFR PMC7893136__F3 Effect of treatment with EPS L (A,B) or EPS P (B) on apoptotic signaling pathway RIPK1 IRAK1 TNFSF10 BCL2L1 TNFRSF10A TRAF2 IL1B PMC5266718__F8 Schematic model of the S EGF EGFR ARHA PMC8473743__F5 Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease TBK1 HSP90AB1 PTGS2 TGFBR2 FGFR3 IRAK4 RAC1 MTOR IKBKB CASP3 FGFR1 RELA PIK3CA NOS2 PMC3738179__F1 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling PTCH1 GC SMO PMC6627039__F1 Viral appropriation of cellular nucleocytoplasmic transport STAT1 NUP153 NUP98 IRF3 NUP62 NDC1 NUP155 PMC8452524__F2A Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs TBK1 IRF7 IRF3 MYD88 TLR3 ADAM17 NLRP3 TLR8 TLR7 COX11 FURIN ACE2 TMPRSS2 MAVS STAT3 PMC3837323__F1 PI3K/Akt/mTOR signaling pathway TSC2 BAD TSC1 RAG1 MDM2 ARHA RAC1 DEPTOR EIF4B RAG2 RHEB SKP2 PMC5827530__F7 Gemcitabine/birinapant effects on upstream regulatory proteins ABCD3 PML ADD1 CRABP2 PPL EVPL EVL WAS HCTP4 HMOX1 CLU HEL-S-22 NOG PAWR CCNB1 CKAP2 DUT KRT4 EPHA2 PYCARD KRT14 FASN BAX PMC8010701__F2 Mevalonate pathway SQLE CS DHCR24 MVK HMGCS1 IPP HMGCR ACAT2 PMVK ACAT1 MVD DHCR7 FDPS FDFT1 PMC2781822__F2 Resolution of immune activation defines nonpathogenic SIV infection PDC TLR7 IRAK1 TRAF6 IRF3 MYD88 MTOR PMC5432227__F6 Metabolic heterogeneity signature of primary treatment-naïve prostate cancer PYCR2 PIG59 PRODH ALDH18A1 HEL-S-133P GLS PMC6186045__F5 Regulatory network analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA PSMF1 ANAPC1 TYSND1 PRRG4 PARP12 GMPR SSB RNF4 TNF TRIM26 PMC8010701__F3 Cholesterol homeostatic processes governing the vertebrate retina SQLE CYP27A1 APOB CYP46A1 ACAT1 DHCR24 LDLR MVK ABCA1 RPE HMGCR CD36 PMC3738179__F2 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling PTCH1 SMO GLA PMC5693733__F3 Melatonin and its metabolites act as radioprotectors on epidermal keratinocytes and melanocytes KEAP1 XPC XPA CPD PMC3675167__F8 Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol NLRP3 NLRC4 MYD88 IL1B PMC4696015__F2 Androgen pathway resistance in prostate cancer and therapeutic implications PTEN MTOR PMC6832561__F3 MRNA-miRNA interactions associated with the vascular endothelial growth factor (VEGF) signaling pathway PRKCA BAD PRKCB PTGS2 CASP9 APP SRC SPHK1 APMAP SPHK2 PMC7260598__F2 ACE/Angiotensin II/AT1R and ACE2/MasR axis TLR4 TLR9 ACE2 FOXP3 PMC3122959__F1 Hedgehog signaling in skin cancers BOC KIF7 SUFU GSK3B RAB23 BCL2 SMO GAS1 PMC6778014__F1 SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION BRAF PMC4009948__F1 Cap-dependent and elongation translational control by GNRH EEF2K EGR1 EEF2 FSHB EIF4E MTOR LHB PMC8463267__AF1 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway CD44 CDH2 PMC3757375__F1 Signal Transduction Pathways controlled by the activation of epidermal growth factor receptors (EGFR) EGF EGFR HBEGF TGFA PMC9099445__F1 DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders ATM BLM RBM14 RAD51 PARP1 ATR FUS NEIL1 PMC3206016__F9 Putting into Practice Domain-Linear Motif Interaction Predictions for Exploration of Protein Networks ARHA NET1 MAGI1 PMC7833977__F9 Interferon stimulating genes (ISGs) in the pathway ISG15 OAS3 STAT2 IRF7 IRF9 CAMK2G IFNGR2 TYK2 IFNAR2 JAK1 MX1 PMC4935448__F4 Proposed model of miRNA regulation by simvastation and possible protective role of ubiquinol GALNT7 IRAK1 TRAF6 BCL2 ABCA1 ABCB11 PMC3995058__F4 Mechanism of rejection of MHCIINEG myeloma cells by Id-specific CD4+ T cells CD27 CD2 CXCL10 APC CCR7 CD44 CXCL9 CD200 CD40 CD80 CD69 PMC7826519__F3 Lipid synthetic pathway MTOR DEPTOR FASN MLST8 PMC4836208__F3 Targeting aberrant HH-GLI pathway SUFU SMO PMC9312479__F1 Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis TSC2 NLRP3 PINK1 CS TXNIP REL MTOR SIRT3 PMC4836208__F1 Key components of the mammalian HH signalling pathway HHIP NUMB SOX2 PDGFRA FOXM1 GSK3B BMI1 HES1 SUFU GLI3 BCL2 SMO SPOP IGFBP6 MEF2C ITCH PMC6942366__F8 The role of HULC in hLCSCs ATG3 SIRT1 PMC8629895__F9 Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells NLRP3 ATF4 EIF2A SESN2 IL1B GSDMD PMC7938643__F1 Interplay between the renin-angiotensin-aldosterone system (RAAS) and the bradykinin (BK) system and chymase PLG ACE2 PMC5431483__F1 PI3K/Akt/mTOR signaling pathway and pharmacological compounds used to modulate its activity TSC1 GSK3B PTEN RHEB PMC2571037__F1 Anticancer therapy: boosting the bang of Bim BAD PTEN MTOR PMC9499983__F6 RNA modifications: importance in immune cell biology and related diseases YTHDF2 EBI3 YBX1 LRPPRC HSF1 IGF2BP2 YTHDC1 YTHDF1 METTL1 METTL14 TRMT10C METTL3 IGF2BP3 WDR4 RRP8 JUNB TRMT6 NSUN2 TARDBP STAT3 PMC6316356__F2 Graphic representation of the hepatic Hepc pathway in conditions of systemic iron increase TMPRSS6 HFE TFR2 PMC3307881__F5 Inhibition of the Nedd8 system sensitizes cells to DNA Inter-strand crosslinking agents FANCD2 ATM ATR PCNA PMC11274515__F1 Signaling cascades of autophagy in hepatocellular carcinoma cells (HCCs) ULK1 EGFR PTEN PMC11274515__F3 Various natural compounds (EGCG, emodin, quercetin and crocin) inhibit HCC through interconnected signaling pathways TNF MTOR PMC9237249__F2 COVID-19 Causing ARDS: Exploring the Possibility of Preventing and Treating SARS-CoV-2 TNF ACE2 PMC6625100__F7 Showing Possible effect of the mutation in leptin–leptin receptor signaling pathway RET MOS SOCS3 GRB2 STAT3 PMC5685683__F6 BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion MMP2 MMP9 DAB2IP PMC7389686__F1 Proteins associated with LGMD and other muscle diseases such as DMD PYROXD1 POMGNT2 TRAPPC11 POMT1 POMT2 PMC4450280__F4 Estrogen regulates TNFA NFKB signaling pathway of osteoclasts PSMD13 PSMD7 PSMD12 PSMD6 PSMD1 TNFRSF11A PSMC1 PSMD3 PMC4450280__F5 Estrogen regulates apoptosis signaling pathway of osteoclasts CASP6 MAP3K1 MAP2K4 TRADD BIRC5 MAPK10 TRAF3 CASP2 CASP10 DIABLO CASP3 APAF1 TRAF1 CASP9 TRAF2 JUN CASP8 FADD CASP4 BAX PMC3224136__F7 Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway ATF4 EIF2A STC2 ATF3 PMC4450280__F6 Estrogen regulates MAPK signaling pathway of osteoclasts CASP6 MAP3K1 MAP2K4 MAPK8 MAPK10 IL1R2 CASP2 RAC1 HEL-S-31 CASP3 PAK1 CASP9 JUN CASP8 CDC42 PMC4450280__F7 Estrogen regulates cell adhesion and polarization signaling pathway of osteoclasts ROCK2 RAPGEF1 MAPK9 ITGB3 MAPK8 ROCK1 MYL6 ITGB6 ARHA RAC1 ITGB1 CRK CRKL ITGB4 RAC3 RAP1A ITGB8 ITGB7 JUN RHOB CDC42 PMC4791205__F11 YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells FGFR1 FGFR3 FGFR4 LATS1 LATS2 FGFR2 PMC4450280__F8 Estrogen regulates Delta-Notch signaling pathway of osteoclasts NOTCH2 RELA GSK3B NOTCH1 ADAM10 NCOR2 PMC4747906__F1 Epidermal growth factor receptor (EGFR) is restricted to the basal surface of the airway epithelial cells EGF EGFR PMC4931665__F1 NFKB signaling consists of two main branches: canonical and non-canonical MMP9 CD44 RELB CD40 CXCL12 TNF LTBR PMC9405087__F2 Neutrophils and Neutrophil Extracellular Traps in Cardiovascular Disease: An Overview and Potential Therapeutic Approaches HMGB1 VWF PMC5763573__F6 TGF-Beta-induced fibrosis signaling pathway MMP2 SMAD2 MMP9 SMAD4 PMC6789908__F1 Rationale and workflow of CRISPR-BEST KY GC PSG5 PMC5054600__F7 Working model of lifespan extension induced by impt-1 knockdown in C IMPACT ATF5 GCN1 PMC10944225__F8 Schematic summary of the mechanism of the role of BMP2 and the BMPR/Smad1 signaling pathway in the modulation of CGRP expression and progression of BCP CALCA BMP2 SMAD4 SMAD1 PMC2864407__F1 Description of the sex hormone metabolic pathway: genes involved in synthesis, bioactivation, metabolism, and inactivation of estrogen and other hormones SHBG NR3A2 PGR CYP11A1 PMC11817786__F5 Integrative multi-omics data analysis, including DEGs, DEPs, and DElncRNAs TSC2 ITGB4 PRKCZ INS LAMB3 SEMA3C PYGM PMC19384__F10 A model of thymic differentiation CDA IL7R PMC2631307__F1 Glucocorticoids and neonatal brain injury: the hedgehog connection CORT IGF1 SHH SMO PMC4556222__F2 Androgen synthesis pathway HSD3B1 CYP11A1 AKR1C1 CYP7B1 HSD17B2 HSD17B3 AKR1C2 CYP17A1 UGT2B15 PMC5902856__F4 Comparison of phospholipid (PL) synthesis and lipoprotein (LP) formation pathways between 0.16, 2.5 and 10 g salmon PGP CHPT1 PISD PRELP PEMT CD36 PMC9545829__F7 miR‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis NFKBIA CCL20 IL17RC CEBPB PMC7479481__F2 Major signalling pathways of DNA sensors CGAS IRF7 DHX36 RIGI IRF3 MYD88 TNF AIM2 IFI16 PMC6600158__F2 Ubiquitination-monitored regulation of the Wnt/Beta-Catenin pathway in colorectal cancer (CRC) cells TLE3 SIAH1 APC RNF6 UBE2O UBE2S PMC8504117__F2 Advances in the study of emodin: an update on pharmacological properties and mechanistic basis SMAD2 SMURF2 SMAD4 NOTCH1 TBR1 MTA3 SIRT1 HES1 PMC4890888__F2 EGFR signalling pathway EGF EGFR MTOR PMC6006192__F1 The intramitochondrial iron–sulfur cluster biosynthesis pathway (see text for details) LIAS ABCB7 SLC25A28 ISCU NFU1 BOLA3 ISCA2 ISCA1 FDXR PMC3913761__F2 Emerging roles of store-operated Ca2+ entry through STIM and ORAI proteins in immunity, hemostasis and cancer EGF ORAI3 ORAI1 STIM1 PMC11307123__F6 Mechanism of diabetes promoting myocardial fibrosis via AMP-activated protein kinase (AMPK)/enhancer of zeste homolog 2 (EZH2)/peroxisome proliferator-activated receptor G (PPARG) signaling pathway EZH2 SUZ12 EED PMC10137169__F1 One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes CTH HEL-S-61p HEL-S-182mP MTR PC PEMT PMC6678221__F1 Role of the canonical Wnt/Beta-catenin pathway in cancer metabolism SCD APC LRP5 LRP6 PMC6004076__F3 Mitotic errors can trigger activation of p53 ATM MDM2 CASP2 LATS2 PMC9600220__F2 Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions PIN1 IRAK1 SIGIRR IL33 TRAF6 IRAK4 MYD88 MTOR GATA3 STAT3 PMC6167061__F2 (A, B) Intracellular pharmacological chaperoning and matchmaking of G protein-coupled receptors (GPCRs) and downstream effects ATF4 EIF2A XBP1 PMC2696319__F1 Sites of mutation which can result in activation of the Raf>MEK>ERK pathway KIT LYN SRC PMC4720504__F1 Apoptosis pathway: (A) The different paths that a cell can take during the activation of cell death APAF1 TNF FADD BAX PMC9913267__F3 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis PTGR1 HEL-S-298 COX1 PGC PMC9913267__F4 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis LTC4S DPEP2 PMC6813721__F7 Inferred role of ACSL1 in sepsis FACL4 ACSL1 TNF IFNG PMC11959162__F2 Phosphorylation in signaling pathways involved in osteoblast differentiation RUNX2 SUFU LRP5 SMAD4 LRP6 SMO SMAD1 DKFZp781O1323 SOX9 SMAD9 PMC10876676__F2 Upon infection with HIV, the virus infiltrates cluster differentiation positive (CD4+) T-lymphocytes and induce pro-inflammatory intracellular micro-environment marked by increased ILB MPO VCAM1 CRP PMC11959162__F3 Ubiquitination in bone homeostasis and osteoporosis USP26 RUNX2 YAP1 SMAD2 LRP5 LRP6 SMURF1 FGFR2 NEDD4 SMURF2 FBXO31 SMAD1 DKFZp781O1323 SKP2 PMC3509680__F3 Functional roles of the arenavirus Z protein in the viral life cycle PML IRF3 EIF4E PMC4226683__F6A Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease MMP10 CXCL1 CXCR1 CXCL5 MMP9 IL8RB CXCL3 CXCL2 IL6 CCL2 MMP3 IL23A CCL20 CXCL6 PMC3701121__F3 Angiogenesis signaling pathways in epilepsy VEGFA CASP9 SRC RHO PMC7330666__F2 EGFL6 regulates angiogenesis by activating Akt/ERK signaling GSK3B MTOR EGFL6 PMC9587056__F9 Hypothesis-driven dragging of transcriptomic data to analyze proven targeted pathways in Rhinella arenarum larvae exposed to organophosphorus pesticides NFE2 AIP LOC51064 AHRR DAO FOS OAZ1 GPX1 GPX8 GPX3 AHR SMOX HEL-S-64p PAOX HEL126 PMC7330666__F3 EGFL6 promotes tumor development by activating Wnt/Beta-catenin and Akt/ERK signaling pathways LEF1 APC GSK3B AXIN1 MTOR EGFL6 PMC4570097__F1 T-MPs function as novel cell-free cancer vaccines CGAS CD80 PMC9066134__F1 Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients APC ACE2 PMC3736525__F3 Lycopene induces cell-cycle arrest and apoptosis IGBP1 BAD IGF1R GSK3B MDM2 CDK4 IRS1 CDK6 SKP2 PMC3736525__F4 Lycopene inhibits theWnt/Beta-catenin pathway IGBP1 IGF1R APC SP1 PMC11882405__F9 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action GPX4 ATM SLC7A11 MDM2 CCND1 CDK4 ATR PMC4278306__F2 SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types SOX2 GLI3 SHH SOX1 SOX17 SOX4 HES1 TEAD2 PMC7996097__F8 Mechanism of how taurine relieves S ULK1 TLR4 IL6 PTEN MTOR PMC8721187__F3 Insights into the role of paraoxonase 2 in human pathophysiology PON2 EIF2A GSK3B PMC7673844__F1 Sources of serine PSAT1 SHMT1 PSPH HEL-S-51e PHGDH PMC9463538__F12 MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway PMC4183925__F2 Metabolic pathway of insulin signalling pathway for unigenes by KEGG annotation TSC2 BAD PDK2 GRB2 INS EIF4E MTOR RHEB INSR PMC4939337__F3 Circadian Rhythm Signaling pathway AVP SNAP25 VIP PER2 PER3 PMC2964117__F2 Small-molecule inhibition of the parasite nicotinate mononucleotide adenylyltransferase (NMNAT) NADK CPD PMC4122293__F8 Fibronectin Stimulates Endothelin-1 Synthesis in Rat Hepatic Myofibroblasts via a Src/ERK Regulated Signaling Pathway GRB2 SRC ARHA PMC6662310__F1 Schematic of TriPOINT PIK3CD PIK3R1 IGF1R FGF2 IMPACT MAPK3 MAPK14 MAP2K2 HRAS PIK3R3 SMAD9 BMP4 MAPK12 MAPK13 MAP2K1 EMP2 PIK3CA RAF1 MAPK11 SMAD1 PMC12026460__F3 Comprehensive mechanism by which Irisin influences fibrosis Via Sirtuin 1 (Sirt1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1A)/nuclear respiratory factor 1 (NRF-1), and related pathways PINK1 NRF1 SMAD4 SIRT1 PMC11314475__F5 Investigating the Molecular Mechanisms of Resveratrol in Treating Cardiometabolic Multimorbidity: A Network Pharmacology and Bioinformatics Approach with Molecular Docking Validation EPOR SOCS2 NRF1 SOCS3 HTR1B THBD MAPK8 ALB HEL-S-99n MAPK14 CELSR2 IFNG TTF2 KL HPGD DBH LPL B2M TFAM APOE SCARB1 CALU FGF16 PIGR TNF IRS1 THPO VEGFC DHFR MAPK11 TERT FGF4 CGAS REN MPO KPG_011 SELENOP PGR DPP4 DES ANXA6 RHO SLC22A2 SLC22A1 CLU THRA DAG1 PCSK9 VWF CD40LG PYY PBR FASN FGF7 CTH MGP DPYD TMEM126A MYOCD PTGES HDAC1 STAT4 NOX3 MGLL TPO FMR1 HMOX1 KNS2 TXN RYR2 PMP22 STRN ANXA2 FGF10 HDAC2 HEL114 GSTM3 ACAD10 ENPEP LIMK1 HAVCR1 CILP2 PLG C10orf2 GTF2H4 ADGRL2 GALNT19 DNAAF3 G6PC1 TMEM216 MGME1 GAST BUD13 PMVK DHCR7 BMP10 HEL-S-64p HEL107 PNP HEL-S-62p ITPR2 MICB NBEA INS NOX4 CALCR OPTN DMD FST APOM FGF23 JUP CFD MICA EXOSC10 NCOA1 NPC1 AIRE TG HPSE CENPO CPB2 EMD GPX3 NCOR1 EPO HDAC3 UCN RDX APOL1 FGFR1 GHR MAPK1 NPC2 CA4 IRF-1 ADK MAP3K1 CTSK NCL EPHX1 AREG GFAP MAPK7 GSTM1 MAP3K7 MAP3K5 HAS1 FGF12 DIABLO HEL-S-68p LEP EDNRB SPHK1 PCNA ENTPD1 FGF21 EPCAM GPX1 AHR KYNU CFH LEPR MGAM PRSS1 ANXA1 XYLT1 BMP2 HEL-S-162eP TAGLN RFC4 RFC2 HP ADA SRI CTSS PPP3CA APLN DUOX1 DUOX2 NBN ADSL GPX2 PPT1 TCF21 MYOG NAMPT ChAT HMMR HEL113 SLC40A1 SYP AGRN F13A1 RETN HGF EGFR BMP4 RARA UROD CRP NR1A2 TFPI PF4 FGF6 BMP7 TCF19 PEX3 KCNB1 HEL-S-130P PRL KCNA1 CCK HEL111 ICAM3 OXTR CYGB VEGFB SOCS1 STAT3 PMC3892938__F2 A schematic representation of IL-12 family cytokines and the corresponding receptors and JAK-STAT signaling pathways IL10 STAT1 EBI3 STAT4 TYK2 IL23R IL12RB1 IFNG STAT3 PMC6338918__F1A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis TAS1R3 PLCL2 SHOX2 HIVEP3 PRR12 HSBP1 RUNX2 ODZ1 GTF3C6 SLC25A36 KIAA1217 OSTF1 CLEC16A CPEB2 APP NWD2 PMC3798724__F2 Wnt signaling pathway in the primary cilia FZD3 APC PMC3798724__F3 Hedgehog signaling pathway in the primary cilia SUFU SMO SPOP PMC2793049__F2 Leptin signaling and leptin resistance TSC2 TSC1 SOCS3 SRC SH2B1 MTOR STAT3 PMC5341618__F1 Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms TBK1 MFN1 ATG12 BCL2L13 AMBRA1 FUNDC1 MUL1 LRPPRC MAP1LC3A ULK2 ATG10 USP30 OPTN DKFZp686F0183 NBR1 PINK1 MFN2 MAP1LC3C BNIP3 FIS1 PMC11353125__F1 Receptor tyrosine kinases (RTKs), epidermal growth factor receptor (EGFR), and its variant EGFRvIII activate the PI3K/AKT signaling pathway, subsequently influencing mTOR activity RICTOR ULK1 PDK2 EGFR PTEN PMC10484649__F4 Mitogen-activated protein kinase (MAPK) signal pathway in subchondral bone RUNX2 ATF4 DLX5 PMC2993798__F6 A conserved insulin signaling pathway in C SGK1 INSR PMC8576031__F3 Therapeutic vulnerabilities and regulation of SLFN11-mediated cell death SLFN11 EZH1 ATR IFNG PMC6461634__F5 Proposed de novo synthetic pathway of monorhamnolipids in Pseudomonas guguanensis HEL-S-11 HEL-S-5 PMC3610926__F2 Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII PLN BCR CAV3 MCU CAV2 PMC3323126__F3 Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus EGFR CD44 LATS1 LATS2 PMC9549209__F7 Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression CPT2 TG ACOX1 CD36 PMC3317170__F3 Proposed models for the activation of intracellular TLR9 and TLR3 by Leishmania TLR9 CXCL10 CCL5 IL6 TNF TLR3 IFNG PMC3317170__F1 The activation of TLR2 by Leishmania sp., leading to a proinflammatory (left), or anti-inflammatory arm (centre and right) TH TLR4 SOCS3 MYD88 PMC6087481__F1 Type I IFN-dependent pathway and ER stress response-induced pathway of IFNAR1 degradation TYK2 IFNAR1 PMC3160333__F2 One Carbon Metabolism in SAR11 Pelagic Marine Bacteria HEL-S-61p PMC11882405__F6 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action PTEN HEL-S-133P HK2 PMC7237219__F7 The role of FGF signaling pathway in blood cell migration SULF1 TTK RAC1 PMC6087481__F2 Influenza HA-induced degradation of IFNAR1 blocks the IFNAR signaling pathway STAT1 STAT2 IRF9 TYK2 JAK1 IFNAR1 PMC11882405__F7 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action TBK1 TRAF5 RELA TRAF3 RELB MYD88 TNF TRAF2 LTBR PMC11882405__F8 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action BAD KSR1 GRB2 NR3B3 PMC9200072__F4 Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids SULT2A1 STAR PMC7826839__F1 Role of the adenosinergic pathway in the Glioblastoma microenvironment EGFR IL6 CTLA4 LAG3 TNF FOXP3 SIRPA AHR CCL17 ADA APP IL2 GSC HEL113 PMC5223135__F4 Proposed mechanisms of kefir peptides-mediated modulation of the lipid metabolism pathway in 30% fructose-induced NAFLD mice SOCS3 TG STAT3 PMC5983871__F11 Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein GCA PC ACBD3 ARF1 ART1 PI4KB GBF1 PMC7785019__F4 Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog NONO IPP NAPA HEL-S-5 PMC7167271__F9 PPI plot of IR and fatty acid oxidation ACACA PHYH MTOR PMC5485763__F2 Therapeutic Wound Healing Targets of miR-21Schematic diagram of miR-21 targets TIMP3 and PTEN BAD KDR CSK TIMP3 PTEN RAF1 MTOR PMC8618084__F2 Syngas Fermentation for the Production of Bio-Based Polymers: A Review MTR HBD PMC6696068__F1 Canonical Wnt/Beta-catenin signaling pathway BIRC5 APC GSK3B CCND1 TNKS BCL9 PMC3827157__F4 Transcriptome Analysis of PPARG Target Genes Reveals the Involvement of Lysyl Oxidase in Human Placental Cytotrophoblast Invasion IGF1R ANGPTL4 MGLL DPP4 HEL-S-99n ARHGEF3 GADD45A HEL-S-104 HMOX1 INSIG1 ACSL1 ABCG2 NR3B3 PPARG PMC8391952__F1 Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine RET EPO PMC6613612__F7 Differentially expressed genes in p53 signaling pathway MYC PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 AIFM2 PERP ATM MDM2 CASP9 ATR SIVA1 BAX PMC3946160__F4 Glutamate, BDNF, insulin and glucagon-like peptide 1 (GLP-1) improve neuronal bioenergetics and protect the neurons against neurodegenerative disease and traumatic injury FGF2 MTOR BDNF PMC9355329__F3 Copy Number Variation of Circulating Tumor DNA (ctDNA) Detected Using NIPT in Neoadjuvant Chemotherapy-Treated Ovarian Cancer Patients NOMO2 ATM HSF1 OTP RHOB CATSPERQ Em:AP000351.3 PMC3861317__F3 Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data FANCD2 ATM BRCA2 SLX4 FANCA ATR BRCA1 PMC5669809__F3 Mixed Chimerism-Based Transplant Tolerance APC CD40 JAK3 CD80 PTEN MTOR BAX PMC3688869__F5 Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer CASP3 BAD SMAD2 APC CASP9 MSH2 DCC BAX PMC4816162__F1 Mitochondria-mediated intrinsic (a) and death receptor-mediated extrinsic (b) pathway TRADD FADD BAX PMC5587377__F2 Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a “Watch-and-Wait” Approach to Cancer VASP BAD HEL-S-28 SHE ARHA PTEN BAG1 PMC8064518__F1 Canonical PI3K-mTOR and GATOR1 signaling pathway and mTORC1-independent pathways TSC2 NPRL2 TSC1 C16orf35 DEPDC5 FLNA FOXG1 PTEN MTOR RHEB PMC8934394__F1 Interaction Between Non-Coding RNAs and Calcium Binding Proteins NLRP3 CAB39 MTOR PMC7483747__F3 IPA TGFB signaling canonical pathway analysis overlaying the WT specific gene list: genes significantly differentially expressed (adjusted p < 0.05) with a |FC|> 2.0 uniquely in WT, E16.5 versus E14.5 RET TLX2 BRAF NODAL GRB2 GSC PAH CP PMC9467392__F7 High expression of CCNB1 driven by ncRNAs is associated with a poor prognosis and tumor immune infiltration in breast cancer ME1 ASPH CYC1 MFAP4 PCNA MAL PMC6326983__F1 Interaction between reprogramming to pluripotency and tumorigenesis JDP2 KLF4 YY1 BMI1 EZH2 HIF1A HRAS PMC4098942__F3 Cancer model pathway EGF FOXB1 ECT2 LIN7C KSR1 EGFR GRB2 PTPN11 MARK1 ARHA HOXB5 PMC3725543__F6 FAK-mediated growth of C2C12 cells in response to IGF-I TSC2 TSC1 IGF1 MTOR PMC3529810__F7 Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response TLR4 IL6 NEDD8 IFNG PMC3706856__F2 The Effect of Curcumin on Breast Cancer Cells CCND1 EZH2 PCNA BAX PMC3676658__F1 Schematic diagram showing the main components of the TGFB signaling pathway SMAD2 SMAD4 PMC5817364__F2 Polyphenols for the treatment of NAFLD KEAP1 IRS1 NR1C1 CD36 PMC4794511__F3 miRNAs and TGFB signaling pathway IGF1 SMAD2 IGFBP5 PMC2789270__F1 TGFB: A New Role for an Old AktTOR MMP2 MMP9 MTOR PMC3649343__F1 The cholinergic anti-inflammatory pathway depicted ChAT APC TNF PMC7294406__F4 Gene product interaction network of “InterferonG” gene set—an up-regulated pathway in subcutaneous fat of OSA subjects relative to those without OSA STAT1 CASP3 TNFSF10 CASP8 IFNG STAT3 PMC7294406__F6 Cholesterol biosynthesis—a pathway that was up-regulated in OSA subjects treated with CPAP SQLE MVD DHCR7 FDPS EBP MVK HSD17B7 TM7SF2 CYP51A1 MSMO1 HMGCR ACAT2 PMC5590639__F9 Possible interactions between PVN inflammation and sympathoexcitation in spontaneously hypertensive rats HMGB1 TLR4 IGF1R CXCR4 MYD88 IL1B PMC11451039__F2 Modulating mechanisms of the Ang/Tie signaling pathway BAD VCAM1 SRC ARHA RAC1 FOXO1 PMC3131208__F4 NFKB signaling pathways BCL10 BCR RELA TRAF3 RELB TRAF6 CD40 MAP3K7IP1 TRAF2 LTBR PMC3131208__F2 Cellular targets of the Tax viral oncoprotein RANBP1 CDK4 CDK6 PMC7260445__F2 Molecular mechanisms that activate membrane damage RIPK1 TRADD C7 C6 RIPK3 IL1B FADD MLKL GSDMD DFNA5 PMC8868465__F2 Uncoupling Proteins: A Systematic Review on the Mechanism Used in the Prevention of Oxidative Stress UCP1 TRO UCP3 UCP2 PMC8901995__F5 Evaluation of Public–Private Partnership in the Veterinary Domain Using Impact Pathway Methodology: In-depth Case Study in the Poultry Sector in Ethiopia MYOF IMPACT PMC9428719__F7 Metabolic management of microenvironment acidity in glioblastoma GOT2 OXCT1 HEL-S-133P ROS1 PMC7352995__F2 Role of fibroblasts in mammary gland branching and BC growth PDGFRA FGF2 EGFR SPRY1 PMC5785559__F8 Diagram of direct and alternative Runx2-Ihh regulation in chondrogenesis NELL1 IHH RUNX3 RUNX2 PMC7835514__F1 Mouse lung development and early pseudoglandular branching morphogenesis HHIP SOX2 GIG8 NKX2-1 FGF10 ETV4 SHH SCGB1A1 ETV5 SOX9 PMC5530473__F1 Considering the spectrum of colorectal cancer (CRC)—conventional adenomas progress by the sequential accumulation of genetic mutations and chromosomal instability causing microsatellite stable (MSS) tumours MLH3 BRAF FAP APC MSH6 SMAD4 MSH2 PMS2 PMS1 PMC5929452__F3 Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis PIK3R1 EPOR EPO KDM5B THBD ASCL1 ATF2 FLT4 MYC RB1 E2F3 OSMR CCNE1 NF1 HEL-S-26 MMP7 IL7R MAPK1 SP1 ANGPT2 RELN TCF3 SOS2 FGF13 GNGT2 RHEB HIF1AN LPAR4 SHC2 EDNRB IGF1 IGFBP2 BCL2 TGFA IFNA17 PGR FOXM1 ETS2 NFYA FGF7 KIT MGP MYBL2 PDGFRA IGF2 PTGER4 CA9 PIK3C2B NFATC2 EP300 MOK CD40 SYK NFE2 KCNK3 POR PRKCA EPHA1 ADM RUNX3 ERG FOS IGFBP7 VEGFA HRAS LAMA4 FOXO1 IL12RB1 GNG3 TNC KDF1 CHAD GABPA ITGAV COMP LAMC1 GNB4 EGF CHUK BAD HEL2 CSF3 EGFR PTEN RPTOR RARA PDGFD ATF4 NGFR E2F2 GNG11 GNS EGR1 SKIL NFATC1 TBX2 HSF2 PDGFC RELA PIK3CA RAF1 STAT3 PMC11702196__F7 Lipid Metabolism Regulatory Network Revealed by Multi-Omics Data Analysis TANK CHUK CREB1 PTEN APAF1 PTPN11 HK2 HSPA4 CD14 PRKCI CXCL2 TNF HRAS CRK GFPT1 PLCB2 ARHG OGA TNFSF10 LBP SHC4 CD40 ABCA1 MSMO1 CYCS CYP27B1 PMC11702196__F8 Pearson Correlation Network of Lipid Metabolism-Related Molecules in Bovine Hepatic Cells Following TMAO Treatment TH ATF2 PMC8637577__F2 Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance DES LPP CERK SPNS2 SMS GLTP PMC6538961__F7 A Model for cFLIPs-Dependent Lethal Ileitis(A) The complex IIb spontaneously forms in IECs overexpressing cFLIPs RIPK1 IL16 CCL20 DUOX2 RIPK3 IL1B MLKL PMC8534198__F4 Methylosystem for Cancer Sieging Strategy YTHDF2 METTL14 METTL3 NNMT ALKBH5 WTAP PMC7725436__F3 Venn diagram of differentially expressed genes RUNX2 NR3A2 FOS MYC TNF HIF1A NFKBIA IGF1 KLF4 SP1 JUN TGFB1 STAT3 PMC1508148__F1 Pathway diagram of genes tested for association IL10 NR1i1 CYP2R1 GC opn CYP24A1 ADRB2 IL12RB1 IL12B CYP27B1 RXRA PMC3265661__F1 Putative role of the mTOR pathway in pathogenesis and epileptogenesis of focal cortical malformations TSC2 TSC1 EIF4E MTOR STRADA RHEB PMC7979776__F7 Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCA and TSC2-mTOR downregulation TSC2 PC BAG3 STUB1 LDB3 HSPB8 HEL-S-72p PMC5407490__F1 AhR signaling inhibits crosstalk with ERA in breast cancer cells and AhR agonists and antagonists are tumor-specific anticancer agents (24, 25) AHR PMC9496174__F1 Gut Microbiota Regulation of AHR Signaling in Liver Disease AIP AHRR AHR SRC PMC5710702__F1 Three interconnected intracellular signaling pathways in pancreatic B cells CCK GIP VIP PMC11042538__F2 Cellular senescence in cancer: molecular mechanisms and therapeutic targets CGAS HIRA ATM IRF3 ME3 TNF MTOR ASF1A ATR CEBPB GATA4 STAT3 PMC5783597__F7 Schematic diagram of the CCL2/CCR2 axis activating Hh signaling CCR2 PTCH1 SHH SMO CCL2 PMC6684366__F2 Biosynthetic pathway of VLC-PUFAs in the mammalian retina ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC8702962__F1 Osteosarcoma and Metastasis RUNX2 MSC CCL5 ID1 FASN PMC6637205__F2 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis FGF21 SMAD2 SMAD4 SP1 SMAD1 SP3 DKFZp781O1323 BMP4 PMC6637205__F3 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis MTOR DEPTOR SKP2 PMC8702962__F4 Osteosarcoma and Metastasis SPARC FGFR1 IGF1 RUNX2 CDH4 CXCR4 FGF2 GSK3B WWOX PMC6637205__F4 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis TGFBR1 RHO MAP3K7IP1 CD2AP CDC42 PMC8568515__F1 MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders ELF2 ATF4 EIF2A XBP1 PMC8428093__F3 Cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor CXCL1 MSC CD44 SHH GPR49 STAT3 PMC10520887__F9 Porcine IKKE is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway TBK1 CGAS IRF3 PMC4236746__F3 Largest key pathway obtained for the colorectal cancer case study PIK3R1 MAFB NGF SORCS3 NEFH RGS12 EWSR1 EEF1G CBL CXCL13 IGSF21 TAF15 CLCA1 ATN1 CD40 MAPK1 NPY2R JUN GFI1B NEFL PMC7223841__F4 NAD+ homeostasis in renal health and disease HAAO HEL-S-90n KYNU KMO AFMID PMC3829926__F1 Phosphatidylinositol 5-phosphate is a second messenger important for cell migration PI3 MTMR3 PIKFYVE PMC4695805__F2 Mitochondrial dysfunction caused by inhibition of pyruvate transfer to mitochondria PDK3 PDK2 PDK4 PMC11922957__F5 Mechanisms of the Draconis Resina on Cardiovascular Diseases PIN1 PLG VCAM1 SMAD2 PTGS2 SMAD4 STAT3 PMC11922957__F3 Multiple Pathways of Draconis Resina Treating MIRI HMGB1 BAX DFNA5 PMC5874668__F4 Angiotensin peptides are derived from the precursor protein angiotensinogen through several enzymatic conversion pathways HGF ATR ACE2 PMC5788303__F1 Activation of the lipid signaling pathway by GluN1/GluN2A receptor and the creation of transporter mediated drug resistance COX2 ABCG2 PMC11978822__F1 MPDOLs for treating primary lung tumors and brain metastases in NSCLC IGF2BP3 EGFR PMC3944267__F8 Proposed mechanism for the differential response of tenocytes to oxidative stress under different extracellular glucose concentrations HIF1A FOXO1 SOX9 PMC8582496__F4 Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement? ID1 SMAD1 DKFZp781O1323 PMC5099257__F6 Multiple signal transduction pathways and transcriptional networks during cold acclimation in D ICE1 CBL PMC6572835__F7 Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma POFUT1 HNF4A SP1 PMC9399075__F1 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease UGCG CERS3 LASS1 CERS5 SPHK1 CERK SPHK2 SMS KDSR CERS2 CERS6 PMC9399075__F2 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease LASS1 CERS2 CERS6 PMC5679454__F4 Tissue force programs cell fate and tumor aggression SCRIB RHO HIF1A PMC9343627__F1 Activation of STING Based on Its Structural Features TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC8080439__F1 Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications HEL-S-62p C4B_2 MASP1 FH APC C1S PMC5437952__F3 Cholesterol metabolism controls plasmacytoid dendritic cell (PDC) innate functions TLR7 VLDLR TLR9 IRF7 ABCG1 LDLR IL6 ABCA1 TNF FASN PMC4605830__F3 Phosphoproteins down-regulated in PCP and PCPPPI compared to Sal and SalPPI, respectively, which were significantly enriched in LTP signaling pathway CREBBP PRKCE MAP2K1 MAP2 PRKCB GRIN1 CAMK2G GRIN2B ARC FMR1 CAMK2A PLCH2 PMC4961996__F2 Transmembrane signaling by TGFB SMAD2 SMAD4 ARHA MTOR SMURF1 PMC5437952__F2 Metabolic changes in plasmacytoid dendritic cells (PDC) providing energy and affecting their innate immune functions: glycolysis versus fatty acid oxidation coupled with OXPHOS PDC TLR7 TLR9 IRF7 IFNAR2 IL6 TNF HIF1A IFNAR1 NR1C1 PMC8960635__F3 Hyaluronan, a double-edged sword in kidney diseases HAS1 JAK1 HAS3 HAS2 STAT3 PMC7920247__F1 PTEN and PI3K/Akt signaling pathway TSC2 EGF TSC1 PTEN RHEB PMC6433975__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of T cell receptor signaling pathway in asthma ITK FYN BCL10 DAO LCK GRB2 CD48 CDK4 CTLA4 LAT CBL PMC10530615__F1 Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria PPCS PPCDC PMC4170638__F6 Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/Beta-catenin signalling in pancreatic adenocarcinoma APC GSK3B LRP5 CCND1 LRP6 STAT3 PMC7772395__F2 This figure displays a suggested relationship between coagulation and inflammation in patients with a SARS-CoV-2-infection IL1A PC PLG APC TF TMPRSS2 PMC9555118__F3 Periostin: biology and function in cancer EGF BMP1 APC EGFR PMC5138853__F6 Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway IL11 IL11RA STAT3 PMC7223841__F2 NAD+ homeostasis in renal health and disease NAPRT NAMPT HEL-S-90n NNT PMC8126620__F1 Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy FYN LCK VAV1 ZAP70 GRB2 LAT PMC6652073__F6 Proposed models of the CoQ10biosynthetic pathway in mammals showing two alternative sequences of reactions (the decaprenyl chain is abbreviated as R) COQ3 COQ2 COQ6 COQ5 COQ7 PMC7354282__F2 Role of the farnesoid X receptor (FXR) and bile acids EGFR APC APOC2 APOC1 CLU APOB RBP4 APOH ATR APOA2 NR1H4 CP APOE PMC8642280__F4 How alcohol affects insulin‐like growth factor‐1's influences on the onset of puberty: A critical review RS1 TSC2 IGF1 MTOR IRS1 RHEB PMC7818184__F4 VPS4B affects tooth development‐related gene expression through Wnt/B‐catenin pathway APC GSK3B VPS4B CHMP4B PMC7190874__F10 Liver analysis UBC HSPA1A PMC6895966__F4 Functional interactions network analysis of co-occurring mutations in pre-NAC samples NUMB RBPJ HEL2 HSP90AB1 RPA1 TGFBR1 GSK3B ERH ARHA RAC1 RB1 HRAS HDAC1 RFC4 CBL RFC1 EP300 RELA PPP2CA SNW1 EZH2 RAN SHC1 CDC42 PMC7354282__F4 Renal diseases HRG C4B_2 CS CFB APC HEL-S-92n AMBP C4A HP GC CRP AHSG CP PMC5894800__F1 Enzymes and binding proteins involved in vitamin A and retinoic acid metabolism CYP26A1 LRAT CYP26B1 PMC6708892__F4 The mechanisms involved in the transformation from NSCLC to SCLC CDK5 MYC RB1 PMC6251040__F1 Three modes of programmed cell death IGF1 APAF1 MTOR MLKL BAX PMC4577049__F1 Up-regulation of the inflammatory response biofunction in Rwandan adults during mild malaria compared with day 30 of convalescence SORT1 MAFB KRT16 JMY IL9 MMP9 SACS TLR1 APOL1 MYBL1 C1QB FCER1G TBX21 CLC C1QA LILRA5 HP CLEC2D LILRB4 LILRB1 CD40LG ADM PMC6571119__F3 Possible interactions between ASD causal genes and RA signaling UBE3A RERE NLGN1 RORA FOXN1 PMC3241725__F2 Bacterial manipulation of mitochondrial cell death pathways CASP3 BAD EGFR GRB2 CASP9 BCL2 BNIP3 CRK SDHA BAX PMC8080831__F3 Core components of the Hippo-YAP pathway WWC1 NF2 AJUBA LATS1 LATS2 FAT1 FRMD6 PMC3241725__F3 Bacterial manipulation of host pro-survival pathway CASP3 NOD1 BCL2 BNIP3 PMC6571119__F4 ASD causal genes affecting BMP signaling and potential crosstalk with other signaling pathways UBE3A NLGN3 SHH FMR1 PMC2903433__F4 Chloride Regulation in the Pain Pathway VAMP2 WNK3 VAMP3 WNK1 OSR1 WNK4 PMC11677427__F4 Under physiological conditions, insulin binding to its receptor (IR), which is auto phosphorylated at Tyr residues and consequently promotes the phosphorylation of its substrate, insulin receptor substrate 1 (IRS1), activates the signaling pathway IGF1 IQGAP1 IRS1 IGF2R PMC9379893__F3 Integration of mechanotransduction pathways and innate immune cell activation EDN1 TRPV4 IL18 PIEZO1 HEL-S-11 IL6 CCL2 TNF mkl1 PMC9379893__F1 An overview of mechanotransduction pathways in cells TRPV4 PIEZO1 SRC mkl1 PMC7460590__F2 Overall signaling cascades, including the TGF-beta SMAD cascade (reproduced with permission of Reactome Pathway, Fabregat et al EPO RHO MTOR PMC4861870__F3 Cellular innate response to rotavirus infection STAT1 STAT2 IRF7 IRF3 TLR3 MAVS PMC7460590__F4 TSP-1-CD36 signaling is inducing apoptosis of tumor associated epithelial cells BAX CD36 PMC9673340__F9 N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway IGF2BP1 GEM CTBP1 ALKBH5 PMC6359026__F3 Estrogen signaling pathways in cancer EGFR GRB2 SRC BCL2 HBEGF PMC6947155__F1 Schematic representation summarizing the main extrinsic (cell–cell contact and growth factors) signals that regulate the Hippo-YAP (Yes-associated protein) pathway EGFR LATS1 LPA LATS2 PMC7106920__F1 Relationship between PCOS and immune cells CXCL10 DCT UNK PMC6947155__F2 Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck EGFR LATS1 LATS2 FAT1 PMC3388731__F5 Canonical Hedgehog signaling PTCH1 MYC CCND1 SMO PMC7072820__F7 MiR-202-5p-mediated SF1 regulation of the canonical TGFB signaling pathway in GCs SMAD2 TGFBR1 TGFBR2 SF1 SMAD4 PMC8837817__F1 Cholinergic anti-inflammatory pathway TLR4 CHRNA7 IL1B STAT3 PMC12124646__F3 Schematic of the mechanism of NMs-mediated SCs in PNR MBP GDNF RAC1 MTOR BDNF PMP22 STAT3 PMC5817803__F2 ALK signaling pathway PTPRB BAD ALK SMO MTOR PMC9170953__F4 Diverse Roles of NETosis in the Pathogenesis of Lupus HMGB1 TLR7 TLR9 PMC7275233__F2 Curcumin-induced apoptotic pathway in human ATM ATR FADD PMC12124646__F5 Mechanisms mediated by NMs that influence macrophage functionality in PNR MRC1 MTOR ARG1 PMC11538887__F8 Mechanism of exosome treatment of androgenetic alopecia CD200 PCNA PMC12027666__F2 S1P-mediated signaling pathways S1PR2 SRC S1PR1 S1PR5 SPHK1 RHO S1PR4 SPNS2 STAT3 PMC11011983__F1 Alterations in Proteostasis Mechanisms in Niemann–Pick Type C Disease NPC1 GABARAP PMC12027666__F1 Sphingolipid synthesis pathways DES SPHK1 CERK SMS PMC7040395__F7 LGK974 on ccRCC LRP5 LRP6 PORCN PMC9329277__F4 Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model CHEK2 IKZF1 ATM BRCA2 Nbla10317 ASXL1 PTPN11 EZH2 WT1 PHF6 PRPF8 GATA2 PMC8585665__F1 Major Ca2+-dependent pathways that could be affected by genes mutated in B-cell lymphomas (Table ) KLHL6 FZD3 S1PR2 TLR9 P2RY8 PTEN MYD88 CD79B CD79A BTK TLR4 BCR CXCR4 CD22 BCL2 SYK CXCL12 PMC11788002__F1 Galactose metabolism and proposed pathophysiology HEL-S-19 PMC11851696__F7 Expression profiles of DEGs in pathways related to IAA, GA, and ABA hormones and reactive oxygen species accumulation TF PMC5993623__F2 Recycling endosome and bacterial pathogens MYRIP TLR4 CD44 PMC4849425__F2 Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation HGF CEBPA CBLC PMC7653241__F1 S‐adenosylmethionine (SAM) biosynthesis and metabolism PMC4684384__F5 Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages CD14 MYD88 IL1B TIRAP PMC7453842__F1 Schematic depicting pantothenate uptake and transformation into CoA through the CoA biosynthetic pathway PPCS PPCDC PMC9238361__F2 Sirtuin Family and Diabetic Kidney Disease SIRT2 NADK SIRT3 SLC36A4 SLC12A8 SLC7A5 NAPRT SIRT7 SLC22A13 SLC5A8 SIRT4 SIRT5 SIRT6 SIRT1 PMC6128695__F1 Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement EBP ARC NPAS4 BDNF CRTC1 PMC7316886__F3 Dysregulated IFN responses in COPD airway epithelial cells STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 SIRT1 PMC4104445__F1 Life in the bile duct CDC20 PRC1 CKS2 TLR4 RNF43 BUB1B TTK SMAD4 ROBO2 IL6 CHST4 PMC8226258__F5 X-Inactive-Specific Transcript: Review of Its Functions in the Carcinogenesis ZEB2 WNT1 MMP9 KLF4 CD44 ABCG2 TET1 PMC6912580__F3 Molecular pathways regarding neuronal survival on which QC seems to assess their effects within the brain NGF MTOR BDNF PMC7316886__F2 Innate immune responses of airway epithelial cells to RV TBK1 CXCL1 CXCL5 CXCL10 TRAF3 CXCL8 TRAF6 IRAK4 IRF3 MYD88 CXCL16 NOS2 IRF-1 MAVS PMC6422901__F2 Schematic for arachidonic acid (AA) pathway: phospholipids from the plasma membrane are mobilized and converted to AA by phospholipase A2 (PLA2) enzyme activity COX2 COX1 LTB LTC4S PMC6422901__F3 EP receptors and their downstream signaling: PGE2 binds to its cognate receptors, the E-series of prostaglandin receptors (EP1–EP4) on the plasma membrane and nuclear membrane SRC FOXC2 TF PMC3132735__F7 CCN2 Is Required for the TGFB Induced Activation of Smad1 - Erk1/2 Signaling Network FLI1 SRC SMAD1 CTGF PMC8914027__F7 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 STAT2 IRF9 TRAF3 TRAF6 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 STAT1 TLR8 TLR7 RHOXF1 TYK2 JAK1 MAVS PMC8914027__F5 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 RRM1 RRM2 RBCK1 GSTM1 PPA2 TRAF3 IRF3 OPTN MAVS PMC5736021__F2 PI3K signaling pathway BAD MDM2 RHEB PMC4918391__F2 HVJ-E-mediated cancer cell death.Notes: (A) HVJ-E-mediated apoptosis signaling in cancer cells with CASP8 CASP3 IRF7 CASP9 IRF3 CASP8 MAVS PMC8914027__F6 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway IRF9 ATF2 ILF3 TYK2 JAK1 IRF-1 PMC6422901__F4 Combating inflammation promoted by KSHV infection: KSHV infection promotes pro-inflammatory lipid mediators of arachidonic acid pathway and the enzymes involved in their synthesis VEGFC MMP2 VEGFA SRC PMC8914027__F3 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 SFPQ TRAF3 INS TRIM25 MAVS PMC8914027__F4 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 TRAF3 TRAF6 MYD88 TLR3 PMC9146201__F1 Targeting Energy Metabolism in Cancer Treatment ENO2 HK2 HEL-S-68p HEL-S-162eP PMC2990476__F3 Functional network identified by genes in the single nucleotide polymorphism (SNP) component using independent component analysis PIK3IP1 SLC12A7 PMC8914027__F1 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 STAT2 IRF9 TRAF3 TRAF6 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 STAT1 TLR8 TLR7 TYK2 JAK1 MAVS PMC9560141__F5 Similarities and differences in circadian control of transcript accumulation in key genes involved in primary metabolism and signalling HP HEL-S-68p PMC8438069__F6 Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS H6PD IL6 IL1B PMC7395714__F1 Surface expression of PD-1, PD-L1 and CTLA-4 CMTM6 LRBA MGAT1 TOX ARF1 CMTM4 PMC3180107__F1 Intrinsic and extrinsic pathways of apoptosis CASP3 CASP9 FADD PMC6477581__F1 microRNA-Mediated Tumor–Microbiota Metabolic Interactions in Colorectal Cancer MTOR HEL-S-133P FASN PMC3180107__F2 Molecular mechanism of autophagy and its role in cell death and survival BAD UVRAG MTOR PMC9666758__F3 Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome AMOT NF2 FGFR4 RASSF6 PMC3035032__F3 Simplified schematic illustrating molecular mechanisms of neurite regulation COBL FYN ARHH RHO PTEN PSD CDC42 STAT3 PMC2430620__F1 Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate EGF GSTM1 TGFB1 PMC10497558__F3 BCAAs metabolism in Cancer IGF1 SIRT4 BCAT1 BCAT2 EIF2A SYK MTOR USP1 PMC3143906__F3 Multiple factors and pathways affect insulin-like growth factor 1 (IGF1)-Akt signaling IGF1 HEL-S-28 PTEN TNF PMC10497558__F5 Aspartate, Arginine and Methionine metabolism MTAP MTR ASNS OTC ASL PMC10497558__F6 Aspartate metabolism in solid tumor SLC25A22 SLC25A13 ZBTB1 ATF4 LCK ASNS SLC1A3 PMC7690754__F17 Pathways involved in BCC pathogenesis HHIP EGF SUFU PTCH1 HEL164 NOTCH1 SMO LATS1 LATS2 PMC10497558__F8 Arginine metabolism in tumor cells SLC7A1 ARG2 ARG1 STAT3 PMC2570554__F4 Anti-apoptotic mechanism of survival and growth of serum-starved 5637 human bladder carcinoma cells BAD HGF SRC HBEGF CBL PMC8290157__F1 RNA Polymerase III, Ageing and Longevity MYC POLL MAF1 POLI PMC4271744__F1 Network analysis of genes significantly modulated in response to mood stabilisers GRB2 JUND HRAS SP3 PMC3762125__F5 Synergy between RasGRP and SOS in TCR signaling PLCG1 GRB2 LAT PMC7918750__F3 Human cytomegalovirus (HCMV) factors that contribute to latency maintenance NAB1 CD34 ACVR1B ARHA IL6 PMC7918750__F4 Human cytomegalovirus (HCMV) microRNA- (miRNA)-mediated reactivation from latency EGR1 EGFR PMC10963930__F0 An active form of vitamin D, calcitriol, directly enhances the expression of Rspo2 by binding to the vitamin D receptor (VDR) NR1i1 MUSK LRP4 RAPSN GPR49 PMC2707261__F1 Regulation of glycolysis, glutaminolysis and de novo nucleotide biosynthesis in tumor cells SRC HEL107 HEL-S-133P PMC7900187__F2 Immune cell amino acid metabolism following mycobacterial infection ARG2 ARG1 ASS1 ASL PMC7999836__F1 Metabolic pathway of PC and TG synthesis PC LPA TG PMC4077819__F5 Inhibition of C3 Convertase Activity by Hepatitis C Virus as an Additional Lesion in the Regulation of Complement Components HEL-S-62p C4B_2 CP PMC9137834__F4 Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications FGFR1 KEAP1 PTEN MTOR STAT3 PMC2894844__F7 Schematic drawing of Akt/GSK-3B/tau signaling HEL-S-28 PDK2 GSK3B PMC6895847__F2 The unfolded protein response (UPR) and its connection to cell death ATF4 EIF2A TRAF2 FADD PMC4519949__F2 Proposed effects of salubrinal on the xenotoxicant-activated ER stress signaling pathways ATF4 EIF2A TRAF2 PMC8422786__F2 Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy ZNRF3 RNF43 APC PMC3226689__F7 Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila HEL70 DDC FOS EGFR PMC3428335__F8 Master Regulators in the Metabolic/Transcriptional Coupling in Breast Carcinomas SQLE PMVK MVD DHCR7 FDPS FDFT1 MVK HMGCS1 TM7SF2 GGPS1 CYP51A1 HMGCR PMC2828273__F1 Interconnections between p53 and IGF-1/AKT/mTOR pathways PDK2 MDM2 PTEN RHEB PMC5852411__F2 NHERF1 pathways EGFR PMC4516163__F1 Numerous arrestin functions play a role in apoptosis and cell survival BAD FOS MDM2 BAX PMC3426219__F2 Chondroitin sulfate proteoglycan 4 (CSPG4) Signaling Pathways HGF MMP2 CSPG4 PMC4809875__F1 Reelin signaling pathway in adult synaptic plasticity FYN VLDLR GSK3B DAB1 MTOR PMC4337036__F2 Schematic overview of intracellular antiviral immune signaling in teleosts TBK1 TLR8 ISG15 ADAR TLR7 IRF7 IRF3 MYD88 TLR3 PMC6572125__F5 Enriched integrin signaling pathway in non-type subtype of bladder carcinoma cell lines HEL-S-28 EGFR TLN1 PTEN PARVA CRK CRKL FYN GRB2 SRC UNK HEL114 PXN CDC42 PTER PMC3098223__F1 Integrative Analysis of Transgenic Alfalfa (Medicago sativa L.) Suggests New Metabolic Control Mechanisms for Monolignol Biosynthesis CCR2 CAD CCR1 PMC9339597__F2 Complement System in Metabolic-Associated Kidney Diseases CD59 C6 C4A PMC6152404__F6 Proposed mechanism for the proliferation inhibitory effects of ART in HCT116 cells ACSL5 ELL FASN PMC9577175__F1 Activation of NOD1 and NOD2 in the development of liver injury and cancer NOD1 TRAF6 RIPK2 NOD2 MYSM1 PMC10158519__F7 Schematic diagram by GroA promotes of expressions of inflammatory mediator TNFA and COX-2 by activating NOD1/RIPK2-mediated JNK, ERK and p38 MAPK pathways in HNSCC progression and metastasis CXCR1 NOD1 IL8RB RIPK2 TNF PMC4622660__F1 Canonical Wnt/Beta-catenin signaling pathway: OFF state COX2 TANK APC MYC LRP5 LRP6 PMC11899831__F3 Mechanotransduction in tumor cells: sensing and transducing mechanical signals from the ECM into intracellular biochemical signals SRC ARHA RCC2 LATS1 RAC1 ARHGAP29 LATS2 HEL-S-31 PMC7144542__F1 NFKB and MAPK signaling pathway in lumpfish CD14 EGF NGF MOS GEM RIGI HEL-S-69p CNTF NLK BTK COX2 MAX ATM BASH RELA CD40 CXCL12 BDNF MEF2C IL1B BPI PMC3064559__F3 Interconnectivity of signaling pathways emanating from TLRs and TACI TRAF5 IRAK1 AID TRAF6 IRAK4 MYD88 TRAF2 PMC2846630__F1 Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1 RICTOR TSC1 IGF1 PTEN GAL DEPTOR IRS1 RHEB HEL-S-162eP PMC3126020__F1 Hedgehog signaling pathway in vertebrates SUFU PTCH1 GLI3 SMO PMC2194118__F6 Molecular dissection of the signaling cascade underlying BCR-controlled integrin A4B1-mediated adhesion BTK BCR BASH LYN SYK PLCG2 CD19 PMC3126020__F2 Targeting the Hedgehog pathway in cancer SUFU PTCH1 BCL2 SMO PMC3461241__F3 Network analysis suggests an immune response and inflammation in ulcerative tissue and non-ulcerative tissue of patients with ulcerative interstitial cystitis (IC) PLCG1 IKBKE CTSS TICAM2 GSK3B NRAS MYD88 MAP2K3 NCK1 ITK BTK LCP2 XCL1 PTK2B TXK IRF7 HLA-DOB VAV1 MAPK10 RAC1 IFNAR2 TNF HLA-DOA CBL LYN GRB2 CD40 SYK LAT NCF2 PMC4790538__F3 Gene–gene networks generated by pathway analysis.Notes: The networks were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA®, QIAGEN Redwood City, www.qiagen.com/ingenuity) TANK KIF23 PGR BIRC5 MMP11 SH3RF1 ORC3 BAG1 TUBB2A TXNDC11 LMNB2 PRC1 RRM2 KNTC2 CCNB1 ETV2 SRC UNK MKI67 SIPA1L1 CENPA EPHA4 PRSS23 MYBL2 GRB7 MPG AURKB CDC45 SEMA6D ERBB2 RAB11FIP4 CMC2 BCL2 ORC1L PPP2R5E SHCBP1 CDT1 PMC10255416__F7 Supplementation affects metabolic reprogramming of cumulus cells in aging ovarian patients CS ENO1 HEL60 HEL-S-32 MDH2 HEL-S-26 FH ACO2 ENO2 SUCLA2 HEL-S-133P SDHA HK2 HEL-S-281 SDHB PMC4917114__F7 An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy CNTN1 PTGS2 GATA6 BCL2 IL6 BMP4 PMC4918724__F5 Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis NDN SDHC ND4L CYB COX2 ND6 NDUFB4 COX3 COX17 ND3 NDUFB3 ND4 SDHD SDHA SDHB PMC7443001__F3 Localization of 38 DEGs in the MAPK signaling pathway CHUK IKBKG BRAF GADD45G TRADD FOS RASA2 MYC TRAF6 FGFR4 DKFZp686L0365 DUSP10 PDGFA NFKB1 EVI1 GRB2 FGF19 TRAF2 MEF2C PMC7443001__F4 Interactions among 38 DEGs involved in the MAPK signaling pathway CHUK IKBKG BRAF GADD45G TRADD RASA2 MYC FGFR4 DKFZp686L0365 FGFR1 PDGFA NFKB1 TRAF2 MEF2C PMC7607189__F1 miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease SFRP4 NUF2 RYBP SAFB F3 AHDC1 FADD LAT BATF PMC6537587__F1 Soluble amylin and pramlintide are capable of activating the endogenous AMYR which is responsible for recruiting adenylate cyclase TRPV4 HEL-S-11 CAD PMC4337782__F1 Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy EGF LIF SHH PMC182218__F2 Osteoblasts express components necessary for coordinating mineralization of ECM and phosphate handling by the kidney FGF23 PTH PMC7370084__F3 Four p38 MAPK isoforms are p38A, p38B, p38G, and p38D ATF2 EEF2 PMC9676924__F3 CD160 receptor in CLL: Current state and future avenues SYK PTEN STAT3 BAX PMC7370084__F4 P38 MAPK signaling pathways STAT1 EEF2K EIF2A MYC ATF1 TRAF6 CD40 RHO RAC1 MYD88 MAP3K7IP1 TRAF2 PMC7370084__F1 Summary of the signal transduction pathways through which acupuncture treats nervous system diseases STAT1 BAD TLR4 MAX MYC ATF1 MYD88 BAX PMC8584200__F3 Rho/ROCK Pathway and Noncoding RNAs: Implications in Ischemic Stroke and Spinal Cord Injury SEMA3A NRP1 ARHA BRD4 PMC6334985__F7 Retinal phosphoproteome GPX4 BBS2 RB1 RHD MYH10 PRPF31 HTT ESRRB BHLHE23 PRPH2 APOE NDUFS4 ADAM9 LAMB2 CRK GNAT1 GABPA RP2 CNGB3 OTX2 FSCN2 XPA GUCY2D CABP4 TUB LAMC1 CPLX4 EGFLAM GNB1 PDE6D CP CRB1 DKFZp686O2183 CRX HEL-S-62p RBP1 USH2A RHO GNGT1 ROM1 MEF2D RDH12 ABCA4 UNC119 GPHN TRPM1 PTPRF RS1 PITPNM2 RP1 ERC2 PTPRE PMC8652208__F3 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation FGF23 SOST PMC8652208__F2 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation FGF23 SOST FGFR4 PMC3855681__F4 An Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway IL10 FOS GSK3B RHO CTLA4 IL5 CBL ITK FYN BCL10 LCK ZAP70 GRB2 IL2 CDK4 IL4 JUN LAT ICOS CDC42 PMC10919309__F4 Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway BAD MYC PTEN MTOR RHEB RXRA TSC2 BCR MDM2 GRB2 SYK EIF4B RBL2 CD19 PMC7210457__F5 BT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells CLSTN2 OTUB2 SHISA2 NR5A2 ASIC3 SYN2 CD34 WNT9A STAP2 ADM2 TNFRSF25 LAMB1 PSAT1 STC2 NXN SESN2 TRIM72 EPHA4 PMC7555965__F4 Molecular pathways involved in aCML SETBP1 TH SET MDM2 TNK2 MTOR GNB1 STAT3 PMC8196501__F8 Photoactivation of TGFB/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model SMAD2 GFAP SMAD4 SMAD1 DKFZp781O1323 SMAD9 PMC10980228__F6 H. Model for the BCM mode of action FES TEC RHO PMC4810618__F7 Selective upregulation of Mcl-1 and HSP27 during HCMV infection of monocytes EGFR SRC MTOR PMC6602950__F6 The rheostat model proposed for Notch signaling network RBPJ EP300 STAT3 PMC8471532__F6 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients MAF KEAP1 NQO1 PMC8471532__F8 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients ELF2 KEAP1 ACE2 PMC8471532__F9 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients MPO MMP9 LPO SIRT1 PMC4460146__F10 The role of Sag in regulation of KrasG12D-induced papillomagenesis SAG SKP1 ERBIN PMC2724778__F3 Hypothesis-driven two-factor common pathway model path diagram of the metabolic syndrome DBP TG PMC5623081__F7 TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated with Hyperlipidemia IRAK1 SRC TRAF6 SYK PLCG2 IRAK4 MYD88 TIRAP CD36 PMC3973216__F4 Simplified representation of the regulation of actin cytoskeleton pathway and differentially regulated genes PI3 OPN3 ELF3 F2R RGS12 CDC42 FGF9 PMC5355309__F10 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis CH25H TLR4 GSK3B PMC8971568__F1 Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus APOB TG HMGCR FASN PMC8899363__F3 Niban apoptosis regulator 1 promotes gemcitabine resistance by activating the focal adhesion kinase signaling pathway in bladder cancer TUBB6 BOP1 FBN1 ITGB6 A2M SNTB2 CD163 SRC DKC1 FERMT2 RBM4 PPFIBP2 FLAD1 HEL70 HRG TP63 DPYSL3 SNX9 ALG5 LAMA4 GATAD2A MCM3 SBSPON MCM2 FIP1L1 ACP2 TNS1 DUSP3 MYLK UBAP2L LMCD1 TF F13A1 WHAMM DYSF H2AC1 MRPL13 ACTN1 PPP1R8 HEL-S-101 RRS1 MYL6 HEL-S-116 TFRC KANK2 PARVA BYSL IGFALS CD81 MRC1 CFD ATM TSR1 SEC61B RBP4 BAX CLTB ELF1 SNRPF LIMS1 GPX3 SNRPE NUP98 CPSF1 HEL-S-51e REL RBM22 TUBB4A WBP11 PMC4110034__F1 Microbial Egress: A Hitchhiker's Guide to Freedom CASP3 RIPK1 RIPK3 MLKL BAX PMC1775040__F4 WNT Pathways APC GSK3B RHO PMC4561339__F1 Schematic diagram of the protein components involved in the myelin protein-derived inhibition of neurite growth HEL-S-62p ARHA LINGO1 PMC8929360__F3 New insights into the role of melatonin in diabetic cardiomyopathy ATF4 EIF2A SIRT1 PMC7031270__F6 IPA generated networks of transcription factors and differentiation markers FOS TP63 FOXQ1 KLF5 GRHL1 DACH1 IVL IRF6 ELF3 CDKN2B DSG1 FLG NOTCH1 CCND1 DSC1 TGM1 PITX1 BARX2 JUN KRT1 KRT10 FOXN1 PMC6179272__F6 Hippo signaling pathway in Duchenne muscular dystrophy LATS1 LATS2 YOD1 ITCH PMC2517590__F2 Schematic overview of the integrin signaling CSK SRC ARHA RAC1 CRKL CDC42 PMC8966131__F4 Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics HEL-S-62p CD14 LBP TNF PTX3 PMC5127598__F5 Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model CASP3 TSC2 SIAH1 ATM CDK2 MYC MDM2 CASP9 PIGS PTEN ATR RFWD2 PMC8821656__F1 Approaches Toward Targeting Matrix Metalloproteases for Prognosis and Therapies in Gynecological Cancer: MicroRNAs as a Molecular Driver AGO1 AGO2 DGCR8 AGO4 DROSHA RAN PMC7443474__F3 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential TSC2 TSC1 IGF1R PTEN PMC7573103__F3 Signaling pathways in TNBC targeted by multiple components of the MD oils COX2 APC GSK3B LRP5 CCND1 LRP6 MTOR PMC7443474__F2 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential RNF11 IRAK1 APC RELA GSK3B ZBTB16 LRP5 TRAF6 LRP6 KDM2A FRAT2 SOCS1 PMC9077270__F8 Alpha-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae VPS35 SNX3 VPS29 PMC7289845__F1 Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus ZNF385A ST7 ZNF274 RAMAC RBM48 SEPTIN2 MRPL57 KIF9 JAKMIP2 PHOSPHO2 BNIP2 RC3H1 OLFML3 GPBP1 MAP7D2 BTK EFHC2 TRIM32 RNF112 ZFHX4 SERINC3 LRP11 CACTIN CUTC PMC11493653__F2 MiRNAs in key phases of diabetic wound healing PDGFD STAT3 PMC7876257__F1 Figure summarizes the potential diet—epigenetic axis in T1DM development MAP2K4 FFAR3 FFAR2 PMC11493653__F3 LncRNAs in main phases of diabetic wound healing STAT1 NLRP3 MFGE8 VEGFA HIF1A STAT3 PMC6402888__F2 Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases TLR4 ABCA1 HEL-S-104 PMC11784099__F9 Antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway STAT1 ISG15 OAS1 CGAS STAT2 IRF7 IRF9 IRF3 JAK1 PMC9648792__F8 Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer BAD NGF RHO RAC1 MTOR HRAS CARD11 BCR HEL-S-11 IL4 REL CDC42 CD19 PMC3748736__F1 Hippo pathway in Drosophila (a) and mammals (b) NF2 AREG PCDHJ DCHS1 CRB3 LATS2 CRB2 FRMD6 CRB1 PMC3108053__F1 Fanconi anemia pathway and ICL repair: implications for cancer therapy FANCD2 ATM FAAP24 UBE2T FANCL ATR RAD51C PMC3255710__F2 Fine adjustment of autophagy by the AMPK-mTORC1-Ulk1/2 kinase network TSC2 ULK1 AMBRA1 ULK2 MTOR RHEB PMC11550943__F3 Metabolic pathways for a metabolism of glucose via the classical hexosamine pathway has a rate-limiting step at phosphofructose kinase (PFK1) that is inhibited by ATP, low pH and citrate SORD KHK HEL-S-162eP PMC9675801__F1 SPATA2 at the level of TNF-RSC RIPK1 TRADD CYLD SHARPIN RIPK3 TNF MAP3K7IP1 TRAF2 CASP8 FADD MLKL PMC11877844__F6 Possible signaling pathways that are partially stimulated by hCG and induce the synthesis of proteins with cell fusion-activating properties ADIPOR1 AKAP12 SDC1 HSD11B2 ATF3 TEAD4 MTOR GCM1 S100P ERVWE1 TRPV2 INHA SP1 PMC6142439__F2 Complement-mediated hemolysis in cold agglutinin disease HEL-S-62p PMC6784137__F4 Interactions between autophagy and immunity in response to viral infection MYD88 ELL PMC3472459__F5 Coordinate regulation by NR signaling pathways of genes encoding enzymes in the de novo purine base biosynthesis pathway HNF4A ADSL SHMT1 PAICS HEL-S-70p PPARG PMC11510019__F3 Illustration of MEHHs’ phenolic acids regulating lipid metabolism pathways APOB CGA SIRT1 HMGCR ACOX1 PMC8190078__F6 RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway GSK3B SRC PMC11510019__F6 Illustration of MEHH phenolic acids mitigating oxidative stress by modulating various pathways ATF4 GPX1 CGA NQO1 HEL-S-5 PMC5550366__F1 Revisiting the Role of Wnt/Beta-catenin Signaling in Prostate Cancer APC MYC PMC6442983__F7 Proposed model for the induction of the Vps34-autophagy pathway in ETV6 RUNX1-positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells CCK UVRAG GATA2 GATA1 PMC2825293__F2 Nutrient sensing machinery in K- and L-cells GIP GPR119 TAS1R2 PMC9658128__F4 Emerging Effects of IL-33 on COVID-19 PDC TLR7 TLR9 IRF7 IRAK1 IL33 TRAF3 TRAF6 IRAK4 MYD88 IL1B PMC2749258__F3 Approaches to biomarkers in human colorectal cancer RUVBL2 USF2 MMP26 RUVBL1 APC GSK3B LRP5 VEGFA CD44 NRCAM TCF7L2 ARHA MAP3K7IP1 WIF1 BMP4 NLK PYGO2 MMP7 ERBIN FRAT1 MSH2 ENC1 MXI1 TCF4 PMC11510019__F4 Depiction of how MEHHs phenolic acids regulate the insulin pathway CGA IRS1 PMC11837477__F8 EGFR role in brain development EGF NUMB SOX2 EGFR SHH HBEGF STAT3 PMC9658128__F2 Emerging Effects of IL-33 on COVID-19 CXCL1 MPO IL33 CD40 CXCL2 CD80 PMC11510019__F5 Illustration of MEHHs’ phenolic acids mitigating the inflammatory response by modulating various pathways NLRP3 KEAP1 VCAM1 TXNIP CGA MYD88 TNF PMC11837477__F9 EGFR role in T cell regulation EGF AREG IL33 HBEGF IFNG PMC11837477__F6 EGFR roles in bone development IGF1R BMP2 EGFR HBEGF PRG4 MTOR TGFA SMAD1 PMC11837477__F4 EGFR roles in IECs proliferation and gut regeneration EREG AREG EGFR JAK1 CDC42 STAT3 PMC11837477__F5 EGFR roles in liver regeneration and fibrosis AREG EGFR SRC HBEGF TGFA ADAM17 CYP7A1 STAT3 PMC11837477__F2 EGFR ligands and signaling pathways activation EREG EPGN EGF BTC AREG EGFR SRC HBEGF TGFA ADAM17 CBL PMC11837477__F3 EGFR role in the placenta development EGF MMP2 MMP9 EGFR KISS1 ID3 STAT3 PMC4823347__F5 Molecular signaling partners of ROCK1 LIMK1 ROCK1 ARHA PMC8421605__F4 Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis LEP HSD17B12 SLC27A4 SCD HACD2 HADHB LPL ELOVL6 ACAT2 PMC3321152__F4 Non-apoptotic functions of apoptosis-regulatory proteins RIPK1 TRADD RIPK3 FADD PMC4461888__F3 p38 MAPK signaling in osteoclasts STAT1 MAPKAPK2 NFATC1 TRAF6 TRAF2 PMC4665627__F6 Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy SPARC FLT1 KDR PMC8963791__F1 Pathways leading to generation of disease biomarkers in NPC NPC1 HEL-S-92n NPC2 PMC4444374__F1A Suppression of Antigen Presentation by IL-10 TBK1 TLR4 IRAK1 IRF3 MYD88 SOCS1 PMC4461888__F1 p38 MAPK signaling in chondrocytes RUNX2 ATF2 BDNF MEF2C PMC4461888__F2 p38 MAPK signaling in osteoblasts RUNX2 PTH DLX5 FGD1 CDC42 PMC4671655__F1 MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells MDM2 YY1 CDC42 PMC5587057__F2 Connectivity analysis of gene products differentially expressed by tissue type and menstrual phase PKIG KRT19 CD6 ARHGEF3 STX1A SOX18 CFI CCR1 RPL12 PDE10A GIPC2 CCL14 APEX1 TCF21 SFRP4 GZMK ERG FCGR3B EDN1 TNFRSF10A GZMH ARHGEF18 EEF2K HERC6 GNLY ETV7 PGR ACACA PTPRN2 CALCRL RAMP3 LGALS2 MAP4K1 TSPAN12 KCNG1 SYBU ZFP69B GPM6A CCDC68 ZBTB16 VWF PGBD5 PRF1 SFRP1 ZMAT4 GNG11 RAMP1 CD3G IL2RB RAMP2 PCDH10 KLF15 CD3D NCAM2 FBP1 C1QL1 TSPAN7 HIF3A PBX1 RPS8 CD79B ID1 IGFBP5 ID3 KLRD1 KLRB1 LCK ITPKA TRAF3IP3 CCL23 PMC5794471__F4 Calcium signaling pathway BCR DAO STOM HEL-S-11 MCU CAV2 PMC5441531__F2 The circadian transcription/translation loop is comprised of rhythmically expressed “clock genes” TTL FBXL3 NPAS2 PMC11208996__F1 Schematic graph illustrating the TGFB/Smad signaling pathway and its roles in the regulation of various biological processes during chronic kidney disease SMAD2 LTB SMAD4 TEC FOXP3 PMC3746560__F7 TG2-containing adhesive/signaling complexes on the cell surface LRP5 SRC LRP6 ARHA PMC3357465__F1 Gene mutations involved in PTC carcinogenesis BRAF HP NTRK1 GRB2 PMC3653431__F2 Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation BMP6 SMAD4 JAK1 SMAD1 DKFZp781O1323 STAT3 PMC8285596__F8 Virilizing doses of testosterone decrease circulating insulin levels and differentially regulate insulin signaling in liver and adipose tissue of females PPARG IRS1 FOXO1 INSR PMC4299585__F10 Mechanisms underlining the sphingosine-1-phosphate (S1P)/sphingosine kinase 1 (SphK1)/S1P receptor (S1PR) 2 signaling axis in pulmonary arterial hypertension (PAH) S1PR2 SPHK1 PAH SPNS2 STAT3 PMC9289270__F1 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization MYH9 CH25H TLR7 TLR4 IL13 CXCR5 MYD88 PMC9289270__F2 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization NLRP3 IL18 NOTCH1 TUG1 HDAC1 STAT3 PMC7261723__F8 Proposed model for the role of Isc1 and Cdc55 in the HU-induced signaling pathway CIB2 CDC20 PC APC INCENP NET1 PMC12192587__F5 Predicted Regulatory Networks Influencing Muscle Fiber Type Transition by ECM Coatings DDR1 NFKB1 SRC MEF2C FOXO1 MYOD1 MEF2D PMC8584317__F3 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis TSC1 EIF4E MTOR PMC2975074__F3 Cell stress response: activation of the aggresome pathway, HSPs, and transcriptional response VCP HSF1 PMC8584317__F1 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis RUNX2 APC SOST GSK3B LRP5 LRP6 PMC2724661__F1 Complement system in AD HEL-S-62p CD59 C9 C7 PMC8584317__F4 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis IHH RUNX2 BMP2 SHH SMO BAX PMC8960266__F1 Imaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet Metabolism TSC2 PMC8623546__F11 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease ATRIP RAD51 NEK8 ATR PMC8301100__F1 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease PINK1 KEAP1 GSK3B RBX1 NQO1 PMC4503872__F3 Results from a transcriptomic analysis of the OCM: Downregulated genes were, dependening on their level colored in green, upregulated in red MTR AHCYL1 SHMT1 DHFR TYMS MTHFD1 HEL-S-51e PMC8301100__F2 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease PINK1 FYN GSK3B PMC8623546__F10 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease LAT2 RHO LAT TF PMC12071115__F2 Relationship between the regulation of TFPI2 expression in cancer cells and host cells MBD3 MYH9 EGF HGF CCND1 TMPRSS4 PSAP ACTN4 TGFBI TIRAP PMC10882314__F2 Emerging role of SENP1 in tumorigenesis and cancer therapy MMP9 SENP1 MYC UBE2T HIF1A GATA1 SIRT3 FGFR1 METTL3 MMP2 HK2 STAT3 BAX PMC4824625__F3 A-to-I editing of coding and non-coding RNAs by ADARs ADAR SUV39H1 IRF3 ENDOV MAVS PMC7926383__F6 Genes of the VEGF-C/VEGFR-3 signaling pathway known to be involved in hereditary lymphedema VEGFC ADAMTS3 PLG FLT4 FURIN PMC4824625__F4 A-to-I editing of coding and non-coding RNAs by ADARs ADAR DROSHA PMC4495933__F3 Secreted Frizzled-related proteins (sFrps) BMP1 WNT3A PMC8357839__F6 Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats KEAP1 TFAM STAT3 MAL PMC4495933__F2 Roles of Wnt/Beta-catenin signaling during vertebrate heart development MESP1 DKK1 PMC3104011__F2 miRNAs regulate DSB DDR through modulating the core protein components of various pathways PLK1 MDC1 MRE11A BRCA1 RNF168 BRCA2 CDK2 MDM2 RAD50 RAD51 CDC2 ATR RAD51B RAD51C BAX PMC8416736__F2 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations VCAM1 ADAM10 IL1B PMC6051890__F32 The diphthamide biosynthetic pathway and the mechanism of diphtheria toxicity DPH2 DPH5 DPH3 DPH1 PMC7155771__F2 The amino acid modulator arm of the mammalian target of rapamycin (mTOR) pathway TSC2 TSC1 SLC38A9 TBC1D7 MTOR RHEB PMC4403556__F1 miR-137 Intersection Target Network of Neurological Disease KIT TJP1 NAB2 PTGS2 FOXN3 RB1 COCH SERPINA3 CACNA1C NF1 DUSP5 GNAT1 SLC12A2 CDK2 HTT KLF4 NOTCH1 SRC TFAP2A MBD2 SGTB TARDBP PTPN5 CDC42 PMC7729087__F4 Aminoacyl-tRNA synthetases and potential therapeutic applications CDH6 AIMP2 MSC PMC3344687__F7 Schematic diagram of the Heme/TLR4/MyD88 and/or TRIF hypothesis in ICH TLR4 IRF3 MYD88 PMC4403556__F2 miR-137 targets within Protein Kinase A (PKA) Signaling Pathway VASP BAD EBI3 PTGS2 MAPK3 SMAD4 CREB1 ARHA PLN NGFR GLI3 ATE1 SMO MAPK1 DCC TCF4 PMC2972700__F1 Wnt Signaling During Fracture Repair LEF1 APC LRP5 SRC SFRP1 RYK ROR2 DKK1 PMC5426069__F6 Analogue signalling pathway of TXNIP mediated by ER stress may be a novel therapeutic target in SAH-related EBI NLRP3 EIF2A TXNIP ATF5 PMC3502657__F2 Signaling pathways for longevity KRI1 TCERG1 KRIT1 PTEN PMC8713066__F1 Gut microbiota and probiotics on Alzheimer’s disease CD14 TLR4 MYD88 TIRAP PMC3502657__F1 Signaling pathways for longevity RICTOR IGF1 PTEN SGK1 RHEB PMC8861075__F1 Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease IDO1 HEL-S-90n KMO IDO2 PMC12250041__F1 Experimental Models and Their Applicability in Inflammation Studies: Rodents, Fish, and Nematodes STAT1 TLR4 MYD88 TLR3 PMC5470738__F1 Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List EPO LDLR LPA PLGRKT AAAS APOE PMC11040350__F1 Platelet Membrane Nanocarriers Cascade Targeting Delivery System to Improve Myocardial Remodeling Post Myocardial Ischemia–Reperfusion Injury TNF ARG1 STAT3 PMC8629847__F1 MyD88 Signaling Leads to Cell Specific Functions in Cardiovascular Disease HMGB1 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 IL1B PMC12071115__F5 TFPI2 in pregnancy-induced hypertension, diabetes, and atherosclerosis TNF EZH1 PMC6299090__F7 miR-100 maintains phenotype of tumor-associated macrophages by targeting mTOR to promote tumor metastasis via Stat5a/IL-1ra pathway in mouse breast cancer GLI3 MTOR PMC3501616__F4 Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome wide association on chromosome 1p22 TP63 ARHA TFAP2A ARHGAP29 IRF6 PMC9626853__F1 Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery HEL-S-62p C4B_2 MASP1 C7 C6 C1S C4A PMC6653007__F1 Ferroptosis induction GPX4 CS SLC7A11 ATF4 SLC3A2 CHAC1 ACSF2 STAT3 PMC6524515__F1 ADAM17/TACE: a key molecule in brain injury regeneration EGFR TGFA ADAM17 PMC8992442__F2 Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance ATM ASXL1 PMC6602878__F3 GDNF expression in Sertoli cells NOTCH2 NOTCH4 RBPJ JAG2 NOTCH1 NOTCH3 PMC7324848__F10 P-TEFb complex activation following activation of the A1-AR or ETR AFF4 CDK9 TF BRD4 PMC7226606__F1 Metabolic reprogramming in cancer cells EGF MDM2 SRC ENO1 PTEN ACLY HEL-S-133P SIRT3 PMC9106060__F4 Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2A and AP-2G Transcription Factors in Bladder Cancer HEL-S-62p RAD1 DAO PKD1 GIP RHO CAD OTP CRK LAT CDC42 PMC4845654__F4 Beyond Beta-catenin: prospects for a larger catenin network in the nucleus APC GSK3B LRP5 LRP6 REST PMC8548824__F3 Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models RET FLT3 MTOR AXL PMC10969083__F6 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways HEL-S-62p PLCB3 MAPK9 IKBKG CHUK MAP2K4 SMAD2 TGFBR1 HEL-S-99n TGFBR2 TRAF6 IFNGR2 IRAK4 MYD88 GNAI1 IFNG NOS2 IFNGR1 PPP2R2A CASP8 JUN CD3E PPP2R2D CD3D FOS IL6 TNF IKBKB PLCB4 PPP2R2B GNA15 RELA GNAI3 PPP2CA PIK3CA BDKRB2 GNAS FADD TGFBI AKT3 PMC10969083__F7 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways PDK2 CPT2 ATP8 NDUFA5 NDUFB8 NDUFS1 NDUFA13 MPC1 MPC2 NDUFA9 NDUFA11 COX6B1 COX7B NDUFS5 NDUFB6 COX7C ATP5PB SDHD NDUFS8 NDUFB5 SDHA SDHB NDUFB11 NDUFS4 NDUFS6 NDUFB9 NDUFA7 NDUFA6 NDUFB2 COX6B2 NDUFS3 COXFA4 PDK4 NDUFC2 PPIF COX6A2 NDUFA2 NDUFB4 NDUFA3 NDUFB7 PDK3 NDUFB3 NDUFC1 PMC8426249__F1 Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse IFIT3 TBK1 CGAS IFNA1 STAT2 IRF7 EIF2AK2 IFNAR2 IFNB1 IL6 IFNAR1 STAT1 ISG15 IL18 GBP3 IFIH1 IL1B TFAM MAVS IFIT1 CLPP PMC10969083__F4 Regulated genes in the Adrenergic signaling in cardiomyocyte KEGG-constructed pathway MYB POPDC2 POPDC1 MYL2 RAPGEF4 MYH7 CACNB4 RYR2 TNNI3 SLC8A2 HEL-S-108 SCN4B ATF4 PPP2R2A PPP2R3A PPP2R3C CACNA2D2 PPP2R2D RPS6KA5 PPP2R5A ADRB2 CACNA2D3 CACNB3 ATP2B1 CALM1 MYH6 PIK3R5 PLN PLCB4 PPP2R2B PLCB2 ATP2B2 PPP2R5C PPP2CA BCL2 ATP2A2 PPP2R5B GNAS CALML3 PPP2R5D CAMK2A AKT3 PMC10969083__F5 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways MYB TPM1 TPM3 DES MYH7 CACNB4 TTN CACNA2D1 RYR2 TNNI3 DMD SLC8A2 ADRB1 CACNA2D3 ATP2A1 CACNB3 TNF LMNA PS1TP5BP1 CACNG8 MYH6 PLN EMD CACNG2 HEL-S-273 MYBPC3 ATP2A2 GNAS TGFBI PMC2173020__F1 Cross-talk between growth factors and integrins in endothelial cells SRC SYK BAX PMC4671844__F1 Molecular pathways leading to CRC BRAF APC MSH6 MSH2 PMS2 PMC4671844__F2 MAPK signaling pathway in CRC EGFR GRB2 MTOR PMC6292222__F3 T cell differentiation APC CCR7 IL2RB PMC4428545__F2 Ratio heatmaps of identified canonical TCR signaling proteins that showed significant changes of phosphopeptide abundance for both types of stimulation (q value < 0.05; > 2–fold or < 0.5-fold) ITK GRB2 PMC8261186__F3 Vitamin D Toxicity Managed with Peritoneal Dialysis FGF23 CYP2R1 CYP24A1 PTH CYP27B1 PMC3228973__F4 Proposed signal transduction pathways in nodose ganglia following receptor activation with leptin and cholecystokinin-8 (CCK-8) SRC ARHA CCKAR PMC5019079__F3 Hypothetical scheme of production and effects of oxidized fatty acids TES PAH RXRA PMC6538889__F1 Switch-on and switch-off of canonical and noncanonical Wnt signal pathway APC LRP5 LRP6 RAC1 JUN PMC8639147__F10 Mechanistic model of REST-dependent homeostatic rearrangement of inhibitory inputs in response to hyperactivity SLC32A1 REST NPAS4 GAD1 PMC2938150__F3 Comparison of fluxes of central carbon metabolism determined by MFA and predicted from a genome-scale metabolic model CS TK1 HEL-S-162eP PMC8136750__F2 NAD Metabolism and its biological role in mammalian cells NAMPT NRK PMC4399270__F4 Functions of Klotho FOXO4 ADA FOXO1 CYP27B1 PMC7645048__F7 LINC02381 effect on Wnt signaling pathway APC PMC3004524__F4 Model of pri-miRNA processing and localization AGO2 DROSHA RAN PMC4870071__F1 Hepatocyte growth factor/mesenchymal epithelial transition factor and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway, and their inhibitors evaluated in gastric cancer patients HGF GRB2 PTEN MTOR PMC3094203__F3 Peroxisome proliferator-activated receptor G (PPARG) is a ligand-activated nuclear receptor with potent anti-inflammatory properties that modulates the immune inflammatory response IL10 CD163 IL4 CD36 PMC8037155__F2 Leptin signaling pathway PC NPY AgRP GRB2 MTOR STAT3 PMC3329985__F4 Top Networks Associated With MK-801 Treatment Identified by Ingenuity Pathway Analysis RARA SFN HTT MYC SNAP25 VRK1 SDHA PMC12030371__F1 Penoxsulam’s Effect on Chlorophyll Synthesis and the Metabolism of Foxtail Millet UROD UROS POR CPO PMC3369606__F2 Role of DCs in the pathogenesis of GVHD VCAM1 CD40 CD80 IL1B ICOS PMC9069066__F5 Differential Physiological, Transcriptomic, and Metabolomic Responses of Paspalum wettsteinii Under High-Temperature Stress PML SDHB PMC5482322__F1 The Plasticity of Cancer Cell Invasion ARHA AMT PMC5216695__F7 Beta-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response IGF1R IGF2 VEGFA PMC4132766__F1 Metabolic pathways for PA production PC LPA MTOR TG HEL-S-5 PMC12119316__F3 CHMs and natural compounds suppress the progression of AS by inhibiting the activation of NLRP3 inflammasome NLRP3 SIRT6 MYD88 SIRT1 SIRT3 PMC2856676__F1 Comparative Genomics of Flowering Time Pathways Using Brachypodium distachyon as a Model for the Temperate Grasses PRR9 CRY1 MSI1 PRR5 EHD1 CRY2 ID1 RFWD2 EFS RFT1 ELF3 MAF1 ELF4 PRR7 AGL PRR3 PMC7828702__F11 TGF-Beta-related oxidative stress signaling pathway in HTMCs (created in BioRender.com) SMAD2 SMAD4 PMC7246985__F6 Proposed model of Amuc_1434* effects on LS174T cells BAX PMC8810793__F8 Overall schematic diagram ATM YAP1 ANKHD1 CCNB1 RAD50 CDC2 H2AX MRE11A PMC9653766__F1 Predictive and Prognostic Role of RAS–RAF–MEK–ERK Pathway Alterations in Breast Cancer: Revision of the Literature and Comparison with the Analysis of Cancer Genomic Datasets PIN1 MAP2 RASGRF2 RASA2 MYC SPRY1 ERF PTEN RASA3 PLXNB1 KSR1 PTPN11 MDM2 MAPK1 ETS2 RAPGEF2 JUN RAPGEF1 DUSP4 SPRY4 FOSL1 RCE1 FOS CNKSR1 HEL-S-34 SCRIB HRAS SPRY2 KSR2 DUSP5 MAP2K1 RASGRP3 RPS6KA1 ICMT RASGRF1 DUSP2 SOS1 RASAL1 DUSP3 RASAL3 RPS6KA2 RASGRP4 PMC3725129__F1 Proposed BP metabolic pathways and their representative metabolites HEL-S-165mP AKR1C1 AKR1C4 BAP1 PMC9708800__F4 Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy NLRP3 IL18 IRAK1 TRAF6 NOX4 IRAK4 MYD88 IL1B SIRT1 GSDMD PMC6160134__F2 TGFB signaling and apoptosis TBK1 MAP3K1 RUNX2 IRF7 SOS2 SMAD6 VEGFA MYC TRAF6 BCL2L1 BCL2L11 CITED2 CASP3 GADD45B BCL10 GDF15 BCL2 DUSP2 CASP8 PMC4147234__F1 Infectious tolerance that depends on a nutrient depleted microenvironment maintained by Treg cells within tissues TPH1 BCAT1 MTOR ARG1 HDC FOXP3 PMC4147234__F2 MTOR pathway in T cells RICTOR TSC1 HEL-S-28 IL2 RHEB FOXP3 PMC7886103__F9 Mechanism for protection of MgIG against ATO-treated cardiotoxicity IL16 TLR4 BAX PMC7739562__F7 Diminished canonical Beta-catenin signaling during osteoblast differentiation contributes to osteopenia in progeria LEF1 RUNX2 APC GSK3B PMC3880276__F9 Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2 TSC2 PRR5 DEPTOR PMC5943138__F2 Control of B-1a cell development by instructive BCR signaling PREB PMC7557502__F1 Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease ERBB4 ERBB2 GRB2 SRC MTOR BAX PMC8965007__F5 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation SHH SMO SMAD1 DKFZp781O1323 PMC8965007__F6 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation APC SMAD1 PMC7564605__F1 IGF-1 signaling pathways ULK1 IGF1R SMAD2 GSK3B SMAD4 PTEN EIF4E IRS1 RHEB IGFALS TSC2 TSC1 IGF1 BNIP3 SMAD1 DKFZp781O1323 PMC9273796__F1 In silico structural and functional characterization of Antheraea mylitta cocoonase CFB LAT2 CTRL NACA PMC4919052__F10 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq PAX7 SMAD4 CCL2 HIF1A XBP1 CEBPB IFNG IRF6 CEBPD STAT1 SMARCA4 ZFP36 FOXA1 GDF15 SP1 IRF-1 JUN IL1B HMGB1 IL10 FOXO3A STAT2 NFE2L2 IL24 IFNB1 IL5 FOXO1 BCL6 EDN1 LEP EP300 EGR2 SPI1 NFKB1 RELA IL-21 REL PYCARD TGFB1 STAT3 PMC8785230__F1 ERRG, a new player in the type I IFN arena IRF7 IRF3 IFNAR2 IFNAR1 TF PMC6310611__F2 Metabolomics reveals the limitations for the in vivo application of GNF-351 due to poor absorption and high metabolism AHR CYP3A4 F2 F5 F3 CYP1A1 PMC4452148__F2 Notch signaling pathway NOTCH2 NOTCH4 NUMB MYC NOTCH1 NOTCH3 PMC2872207__F4 Akt signaling pathway TSC2 RICTOR TSC1 PTEN MTOR RHEB PMC4452148__F3 Wnt/Beta-catenin signaling pathway NLK APC GSK3B TEF LRP5 CCND1 LRP6 PMC6372678__F6 Mitochondrial superoxide dismutase 2 mediates Gamma-irradiation-induced cancer cell invasion SULF2 SRC STAT3 PMC3256499__F2 VEGF pathway and site of action of the inhibitors VEGFC VEGFA VEGFB PMC6545365__F1 Schematic Representation of the Biogenesis and Secretion of ExosomesExosomes are formed as intraluminal vesicles (ILVs) RAB27A RAB27B PMC4089153__F1 Sooner and later HMGB1 IL25 TSLP PMC6682688__F5 ErbB/PI3K pathway regulation by miR-326 BAD ERBB2 ERBB3 GSK3B MYC MDM2 VEGFA MTOR CCND2 AKT3 PMC6406032__F2 Scheme summarizing the role of TRP channels in cardiac fibrosis TRPC4 TRPC1 TRPV4 TRPV2 TRPM6 TRPC6 ARHA TRPC3 TRPV3 TRPM7 TRPV1 PMC8416736__F3 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations SIRT6 KLF4 CCL2 IL1B FADD PMC8416736__F4 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations NLRP3 TLR4 IGF1 ABCA1 IL1B PMC9595130__F3 Ferroptosis and musculoskeletal diseases: “Iron Maiden” cell death may be a promising therapeutic target HEL-S-89n GPX4 LPCAT3 FACL4 SLC7A11 FTH1 ATF3 POR SIRT3 HEL-S-64p TPD52 SLC3A2 ACSL3 BAP1 PMC5996875__F4 Fibroblast growth factor receptors and genes that are involved in FGF pathway were analyzed by IPA in KC iPSC compared with normal iPSC PLCG1 MAPKAPK2 FGFR1 HGF FGFRL1 GRB2 HRAS STAT3 PMC4637293__F1 Anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients MTOR FOXO1 STAT3 BATF PMC2872207__F1 TNF-induced NFKB pathway TRADD CCND1 TNF PMC6350302__F5 Proposed model of PI3K activation in CM-RES clones IGF1R EGFR PTEN MTOR PMC2860895__F1 TOM1L2 and genes associated with Alzheimer's disease in the human interactome CTSF CNNM2 SLIT2 WBP2 SLC13A5 RAB11B GSTT1 DRAP1 APP CROT PRDX5 ARVCF APOE TOM1L2 PSEN2 STXBP1 EHD2 EHD3 SLC30A8 RAB6B QK3 PSEN1 KCNH3 LBP KIFC3 STX12 PMC2872207__F3 Jak/STAT signaling pathway LIF IL6 PMC7946999__F3 Different redox state between naïve CD4+ T cell and synovium in rheumatoid arthritis PMC3507479__F1 An expanded role of the tumor suppressor TSC1 in T cell tolerance TSC2 PLCG1 TSC1 EGR2 RHEB PMC10144535__F7 Classical MAPK signaling pathway altered by 15 μM 7KCh treatment in mRPE cells and reversion effect exerted by 10 μM SA over this modulation GRB2 MPL PMC10902464__F1 Galactose metabolism and CG pathophysiology HEL-S-19 PMC7566900__F2 BMAs-derived adipocytokines regulate behavior of metastatic breast cancer cells in the bone marrow CMKLR1 IL16 TLR4 CAP1 ARHA HEL-S-104 PMC11977057__F6 Mechanism by which phanginin A activated SIK1 to promote glucose uptake in skeletal muscle JUP HDAC7 HDAC5 SIK1 PMC7796379__F2 Scheme of the mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN) in mice treated with paclitaxel (A) or oxaliplatin (B) HMGB1 TLR4 PC APC CXCR4 CXCL12 PMC7433558__F4 IVF-ET对胎盘绒毛FAK信号通路基因表达的影响Effect of IVF-ET on gene expression of FAK signaling pathway in placental villi VASP BAD BRAF HEL-S-28 GRB2 SRC BCL2 PTEN CRK CDC42 PMC8065725__F6 Wnt/Beta-catenin signaling pathway in chronic HCV infection and HCV clearance without (A) or with (B) metformin treatment MYC CCND1 PMC8867697__F1 Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease HEL-S-62p CS CP PMC4814460__F1 Autism spectrum disorders (ASD) candidate genes cluster into functional networks, and the two most prominent are synapse structure/function and protein translational control TSC2 TSC1 DAB1 MTOR RHEB PMC11148314__F4 Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging CGAS ACTR2 PMC2805399__F8 A proposed working model of the complex Sertoli cell-germ cell interaction describing the mechanism by which Sertoli cells trigger germ cell apoptosis following MEHP-induced Sertoli cell injury MMP2 NFKB1 SP1 PMC3236216__F5 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways IRF7 IL33 POLL AIM2 POLI PMC10531892__F9 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients NLRP3 HEL-S-99n PYCARD HEL-S-162eP PMC4563693__F7 Harnessing endogenous stem/progenitor cells for tendon regeneration TNC COL3A1 HEL113 TNMD SCX PMC10531892__F8 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients NLRP3 HEL-S-99n PYCARD IL1B SPDL1 PMC4746415__F2 Expression of genes involved in the fibroblast growth factor (FGF) signaling pathway during goat pre-implantation development SOX2 CDX2 GATA4 PMC10136283__F7 KEGG pathway map for Wnt signaling pathway ROCK2 BAMBI SFRP4 INVS STOM APC SOST NOTUM SMAD4 RYK RBX1 NLK RHOD SIAH1 PMC8218506__F4 Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway CDCA5 KIF23 CCNA2 BIRC5 CENPF CXCL8 CXCL3 CCL5 UBE2S SKA1 KIF15 KNTC1 DLGAP5 CENPA GPR37 PSAP CENPE CDCA8 SPAG5 CDC20 GABBR2 SMURF2 HJURP HEL-S-62p CENPM FOXM1 TTK MYLIP ACKR3 TOP2A KIF11 NUF2 PRC1 KNTC2 RRM2 CCNB1 KIF18A CXCL6 CDC2 SPC25 SPDL1 NUSAP1 ANAPC15 KLHL13 RNF130 ADRA2C RNF182 S1PR1 CXCL2 CEP55 HCTP4 CENPL CENPK AURKA BUB1B NCAPG CCNB2 NEK2 HEL164 KIF20A ZWINT CENPN CENPU PMC3709125__F1 Gene regulatory networks in mammalian sex determination DHH NR5A1 DMRT1 SOX8 FOXL2 FGFR2 GATA4 SOX9 FGF9 SRY FST CBX2 CYP26B1 RSPO1 AMH WNT4 PGC STRA8 VNN1 CBLN4 PMC6776881__F1 Proposed working model of omega-3 PUFAs induced inhibitory effect on inflammation and autoimmunity SOCS3 STAT4 GATA3 PMC4710172__F2 Calcineurin-NFAT pathway: Activation and regulation COX2 CABIN1 ATF2 MDM2 DYRK2 GATA4 PMC4710172__F3 Promotion of cancer development and progression by NFAT CABIN1 MDM2 CCND1 PMC4710172__F4 Inhibition of the calcineurin-NFAT pathway at multiple levels INCA1 COX2 MDM2 PMC6357680__F9 Selected enriched KEGG pathways among DETs between S41 and S43 during tail resorption LEP AFP APP FADD PMC6557020__F2 Mechanisms of the SLIT/ROBO pathway as an oncogene in cancer ROBO3 GSK3B ROBO2 SLIT2 PMC8249877__F1 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development VEGFC AMOT PIEZO1 NF2 SRC LATS1 RHO PMC8249877__F2 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development VEGFC LATS1 SOX18 PROX1 RAF1 LATS2 PMC3853754__F1 The mitochondrial life cycle MFN1 PINK1 MFN2 MFF OPA1 PMC9706587__F9 Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy SIRPA CD47 CSF1R PMC8096694__F1 Potential mechanisms by which Nrf2 signaling is regulated via protein interplay as a therapeutic process and in the pathogenesis of heart failure AREL1 FYN KEAP1 SIRT6 HEL-S-101 FN3K PMC6832489__F1 Wnt/Beta-catenin signal transduction pathway in homeostasis APC GSK3B AXIN1 LRP5 LRP6 AXIN2 PMC8096694__F2 Epigenetic regulations of Nrf2 signaling by noncoding RNAs in the pathogenesis of heart failure CRIP2 KEAP1 SIRT6 SIRT1 BACH1 PMC6832489__F2 Schematic view of sex determination RSPO1 AMH WNT4 SF1 WT1 SOX9 FGF9 SRY PMC8096694__F3 MI-induced cardiac-derived EVs potentially regulate myocardial and brain Nrf2 signaling pathways by intra- and inter-organ communication AREL1 KEAP1 TNF PMC12209371__F1 Role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma MACC1 HGF MTOR STAT3 PMC8385202__F3 Multi-functional roles of forkhead box protein O in skin aging and diseases CCL20 NOTCH1 SERPINB2 PMC11177995__F8 Schematic diagram for the mechanism underlying the apoVs-mediated rescue of the impaired OVX MSCs biological function and their capacity to improve osteoporosis APC LRP5 TGFBR2 LRP6 PMC7338457__F8 PD-L1 promotes tumor growth and progression by activating WIP and Beta-catenin signaling pathways and predicts poor prognosis in lung cancer PDK2 RPS6 MTOR PMC8249877__F3 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development VEGFC PIEZO1 PROX1 FOXC2 ORAI1 PMC4835216__F6 Prostaglandin-mediated inhibition of PTH-stimulated Beta-catenin signaling in osteoblasts by bone marrow macrophages COX2 PTH PMC6661542__F2 Mechanisms involved in the regulation of glycometabolism in T2DM by RC INS RBP4 GIP IRS1 UCP2 INSR PMC4076815__F1 Typical PDA cell is depicted showing schematics of representative metabolic pathways that are altered in the disease in response to oncogenic Kras ME1 GOT2 RPIA RPE HEL-S-32 GFPT1 HK2 GLS PMC11491146__F7 Molecular mechanisms by which CCN2 regulates the activity of TRPV4 channels under mechanical stimulation in fibrochondrocytes TRPV4 SOX9 CTGF PMC10417430__F8 Synergistic effect of N3a with HSPs and mTOR inhibitors in lymphoma cells: Summary of the therapeutic scheme followed in our study, with major findings highlighted in bold MDM2 MTOR PMC8178367__F5 Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells ELF2 CASP12 ATF4 APP BCL2 POR TRAF2 BAX BOK PMC5927454__F15 Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill CYP2E1 PMC3871217__F12 Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways PDC OGT EGFR ITGB1 HEL-S-162eP PMC10417430__F4 Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level PIK3CD PIK3R1 HDAC3 HEL-S-1 GSK3B HSPD1 RB1 SMARCA4 PERP RNF20 APAF1 ZMAT2 MDM2 ZMAT3 CD82 CDK5 DDB2 PIK3R3 UBTF TSC2 YWHAQ CDKN2AIP PPM1D PPP2CA SESN1 SESN2 GTSE1 SIRT1 SUMO1 PML SUMO2 HEL2 SFN PTEN MTOR CCND3 MTA2 RRM2 CCNB1 CCND1 CDK4 THBS1 CDC2 YWHAG PRKDC CCNE2 TOX4 TOX3 CHEK1 HDAC1 CASP3 EP300 SMG1 TRAF2 HEL-S-93 CYCS PIK3R2 PMC8616169__F4 Oncogenic KRAS: Signaling and Drug Resistance EGF EGFR MTOR PMC8074531__F1 Simplified model of insulin-stimulated translocation of the GLUT4 glucose transporter in skeletal muscle PAK1 VAMP2 RAC1 IRS1 SNAP23 PMC2752022__F2 FoxO factors in endothelial cells VCAM1 CCND1 PBX1 PMC2752022__F3 Akt-FoxO pathway in regulation of heart size MTOR TG PMC8560795__F2 Targeting Sphingolipids for Cancer Therapy opn DES SPHK1 SMS HEL-S-5 PMC11894248__F3 An example of the complexity of p21‐activated kinase (Pak1) signaling in a ventricular cardiac myocyte PAK1 RHO CP CDC42 PMC11894248__F4 Scheme illustrating ON and OFF states of the canonical Hippo signaling pathway MOB2 LATS1 MOB1A PMC8224699__F2 Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis EN2 EN1 PMC10451660__F3 AhR signaling pathway AHRR AHR CYP1B1 SRC PMC6941088__F2 The classical and alternative nuclear factor-KB (NFKB) signaling pathways LTB RELB IL1B PMC6374618__F4 Schematic relationships between the wound-induced signal transduction mechanisms for the sesquiterpene biosynthesis and regulation in Aquilaria species for the agarwood production MYB MYC IPP PMC11899273__F2 Schematic diagram of LPS clearance: LPS entering the systemic circulation binds to HDL in the blood to form an LPS–HDL complex TLR4 VCAM1 IL6 MYD88 PMC2796930__F7 FGF-receptor signalling in the generation of hindbrain neural cell diversity SHH OLIG2 SOX9 PMC11899273__F3 Increased expression of FABP4 in LSECs may represent a potential target for liver injury CXCR3 CXCL10 HEL-S-104 PMC8308051__F3 Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological Alpha-Synuclein Expression in an In Vitro Model of Parkinson’s Disease CD47 CD44 VWF CHAD CD36 PMC3329512__F7 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism PDC PC CIC PMC3329512__F3 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism PDC PC MME PMC6478549__F1 An overview of major metabolic pathways in resting and activated fibroblasts AIP PSAT1 F2 PSPH PHGDH GLS PMC3329512__F4 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism PDC PC CIC PMC4841705__F3 Regulation of Macrophage NO Production by H SLC7A2 ARG2 NOS2 HMOX1 PMC6165502__F1 The BMPR2 signaling pathway illustrating the potential canonical (green) and noncanonical (grey, blue) targets that can be activated BMP2 ARHA RAC1 SMURF1 ID1 ID3 FKBP1A BMPR2 GIG8 SMURF2 SMAD1 CLIC4 DKFZp781O1323 PMC3499814__F2 RIG-I signaling pathway and inhibition by influenza A viruses (Figure adapted from ) TBK1 TANK ATF2 TRAF3 TRAF6 IRF3 TRIM25 MAVS PMC3499814__F3 Type I IFN signaling pathway and inhibition by influenza A viruses (Figure adapted from ) STAT1 ISG15 IRF7 IRF9 JAK1 PMC4246236__F1 Cholesterol metabolism, lipid rafts and cellular prion propagation NPC1 ABCA1 APOE HMGCR PMC8583941__F2 Deacetylation of Transcription Factors in Carcinogenesis SIRT2 SIRT7 SIRT6 MDM2 PTEN SIRT1 SKP2 BAX SIRT3 PMC7875488__F7 A HH/Gli-Foxf1-Wnt signaling network controlling Sox9+ chondrogenesis IHH WNT4 NOTUM SHH WNT7B SOX9 FOXF1 PMC3737553__F6 Our proposed model for two distinct pathways in ICL-induced ATR signaling RAD17 TOPBP1 ATRIP ATR PMC10874752__F13 miR-140-y targets TCF4 to regulate the Wnt signaling pathway and promote embryonic feather follicle development in Hungarian white goose APC GSK3B TCF4 PMC5702629__F5 Enriched canonical pathway for toll-like receptor signaling at 48 hps with dsRNA CD14 TLR4 TLR9 LBP TRAF6 IRF3 IRAK4 TNF TLR3 TIRAP CPO PMC4129529__F1 Cell-proliferative signaling pathways in lung cancer cell ERBB4 ERBB2 ERBB3 EGFR PMC5410752__F1 Schema of the migratory modes of the excitatory neurons during neocortical development and molecular mechanisms downstream of Reelin signaling that control neuronal migration CDH2 CP PMC8313358__F2 Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis APC IL10RA PMC7216002__F1 Heme biosynthesis pathway (left) and the principle of HAL mediated PpIX production enhancement with dimethylsulphoxide (DMSO) or deferoxamine mesylate salt (DFO) (right) ABCB6 FECH UROD SLC25A38 HAL UROS HMBS ABCB10 ABCG2 PMC4742122__F6 The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets EGF EGFR SRC RAC1 PMC2593012__F2 Gene expression data mapped on the Mus musculus fatty acid synthesis pathway ACACA FASN HEL-S-5 PMC7730327__F2 TAp63A acts as the central integrator for DNA damage signaling in oocytes ATM ATR BAX PMC2593012__F3 Gene expression data mapped on the mouse insulin signaling pathway MAPK13 MAPK10 FAP JUN MAL PMC9110800__F2 Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases CTCF GC MSH3 MSH2 PMC3260921__F2 Integrin signalling pathway KRIT1 ARHA STK24 PDCD10 PMC3825669__F3 KEGG “cell cycle” pathway relevant to NRF1 target genes E2F4 ORC6 APC SMAD4 CDC25B STAG1 ORC3 CDK7 STAG2 ORC2 CDC20 CDC6 SMC3 CDK2 MDM2 C6 ORC1L CDC2 RAD21 PCNA SKP2 MYT1 PMC3825669__F4 KEGG “Parkinson’s disease” pathway relevant to NRF1 target genes TH CASP3 SNCA KY LRRK2 CASP9 HTRA2 PMC3825669__F6 IPA “regulation of eIF4 and p70S6K signaling” pathway relevant to NRF target genes ELF2 ELF3 PAIP2 PAIP1 GRB2 EIF4E RPS6 ELF4 IRS1 PMC8481579__F5 Paeoniae Radix Alba in the Treatment of Non-alcoholic Fatty Liver Disease Based on Sequential Metabolites Identification Approach, Network Pharmacology, and Binding Affinity Measurement LEP INS LEPR IL6 TRAF2 IRS1 INSR PMC3383919__F1 Schematic model of the Hippo signaling cascade in mammals PATJ AMOT BIRC5 AREG LATS1 PMC8381548__F1 Therapeutic strategies in METex14 skipping mutated non-small cell lung cancer HGF GRB2 SRC STAT3 PMC1315902__F2 Multiple roles for kinases in DNA replication FEN1 PCNA PMC6651423__F2 Mechanism of Activation for the Non-Canonical and Alternative NLRP3 Inflammasome Pathways NLRP3 RIPK1 TLR4 MYD88 FADD PMC3366472__F2 TLR-4 signaling in cancer CD14 HMGB1 IRF3 MYD88 TIRAP MAL PMC3375870__F1 miR-23a, a critical regulator of “migR”ation and metastasis in colorectal cancer HES5 MTSS1 MYC SRC RAC1 JUN FBXW7 RHOB PMC8514722__F7 NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation NFIL3 MTOR IL1B PMC3277529__F1 Proposed model for TIMP-1–mediated suppression of the Wnt/Beta-catenin pathway via let-7f in human mesenchymal stem cells (hMSCs) TIMP1 CD63 APC GSK3B LRP5 LRP6 AXIN2 PMC3032697__F15 Time course changes in cytokine network pathways of lungs from 9 V/null mice ARG2 CD163 MMP15 TNF CCL1 MPL PMC6709637__F9 Summary diagram TGFBR1 CD44 TGFBR2 TGFB1 PMC11766572__F1 MYD88 and IRAK signaling pathway IRAK1 TRAF6 IRAK4 MYD88 TNF PMC5099458__F1 Canonical and noncanonical Notch signaling pathways KEAP1 PMC5520166__F3 Regulatory role of ubiquitin on RIP1 and RIP3-dependent cell death TRADD CYLD SHARPIN TNF MLKL HAP1 PMC9325968__F2 Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens USF1 EBP APC ZAP70 CD80 RAC1 LAT CEACAM1 RAB7L1 PMC5427230__F1 The theophylline metabolic pathway CYP3A4 CYP1A2 CYP2E1 PMC4374755__F7 Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners STAT1 TLR9 TRAF3 TRAF6 IRAK4 MYD88 PMC4826884__F2 Immune signaling in C SGK1 PMC3654365__F5 Summary of the metabolic pathways in which the metabolites described in this paper are involved VIT CIT PMC6996089__F1 Bile acid synthesis pathways ABCD3 CYP27A1 GCA CYP46A1 CYP8B1 AMACR AKR1C4 CYP7B1 SLC27A5 HSD17B4 BAAT HSD3B7 PMC8202879__F7 LncRNAs induce oxidative stress and spermatogenesis by regulating endoplasmic reticulum genes and pathways UGT1A3 GPX3 GCLC GPX1 CYP1A1 XDH POR SP1 CYBB TF PMC11936574__F1 Interleukin-18 signaling pathway and its functional binding with IL-18 receptor NLRP3 IRAK1 TRAF6 IRAK4 MYD88 IL18BP TNF PMC8052259__F1 m6A regulates innate immune signaling pathways YTHDF2 TBK1 TLR4 IRF3 MYD88 TNF MAVS PMC4254984__F4 C-peptide-initiated signaling cascades ARHA IRS1 PMC8052259__F2 m6A regulates IFNB and the type I IFN response YTHDF2 STAT1 YTHDF1 STAT2 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 PMC8052259__F3 m6A regulates immune cell function YTHDF1 TLR4 CISH CD40 JAK3 CD80 MYD88 SOCS1 TIRAP PMC6913124__F7 Putative role of miR-146a in CVB infection IRAK1 TRAF6 TLR3 PMC3128433__F3 Complement cascade, hemolyisis, and eculizumab HEL-S-62p CD59 CD55 PMC3562086__F1 Connecting the Insulin pathway to the Drosophila autophagy machinery TSC2 RICTOR ATG12 ATG3 ATG10 DKFZp686F0183 RHEB PMC9663387__F1 Optogenetic interrogation of cell signalling: human neuropsin (hOPN5) represents a potent tool for controlling the Gq pathway with light TRPC6 GAL PMC5883378__F2 Two signaling pathways TLR8 TLR5 TLR7 TLR4 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAL PMC4285539__F9 Signaling model for IP-10 production induced by MRP8/MRP14 TBK1 TLR4 IRF3 MYD88 PMC9139286__F4 DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease NLRP3 DDX3X CASP8 FADD PMC8657588__F1 Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology TLR8 TLR5 TLR7 TLR4 TLR9 CCL20 IRF3 IL6 MYD88 TLR1 TLR3 PMC3597360__F4 Pathways leading to actin polymerization in the myogenic response VASP SRC ARHA CDC42 PMC6717912__F1 Immune cell development and trafficking to the heart CXCR3 CXCL1 CCR2 VCAM1 CXCL9 CXCL8 CCL5 CXCL2 IL1B ELL PMC8516553__F5 Insights into the Role of Oxidative Stress in Ovarian Cancer APC LRP5 LRP6 PMC8600399__F8 MicroRNA-218-5p in sevoflurane-induced protective effects in hepatic ischemia/reperfusion injury mice by regulating GAB2/PI3K/AKT pathway GAB2 TNF MTOR PMC8323643__F1 Interleukin-10: A double-edged sword in breast cancer SOCS3 GSK3B TYK2 IL10RA STAT3 PMC8019201__F3 Molecular mechanisms of the role of enhancer of zeste homolog 2 (EZH2) in a polycomb repressive complex 2 (PRC2)‐independent manner RELA MYC RELB JAK3 TRIM28 EZH2 RORA TF GATA4 STAT3 PMC5860992__F1 Adapting Secretory Proteostasis and Function through the Unfolded Protein Response ATF4 EIF2A XBP1 PMC6801718__F10 Summary of data showing TGFB1 recruitment of miR-143 and miR-145 to RISC to destabilize CFTR mRNA and impair the corrector/potentiator-mediated rescue of F508del-CFTR AGO2 TGFB1 CFTR PMC11816580__F1 In MASLD, CS affects the AMPK signaling pathway in different ways in the liver (A), adipose tissue (B), and ileum (C) to perturb lipid metabolism MPO KEAP1 MTOR TG IRS1 SIRT1 PMC11816580__F2 Molecular mechanism of CS-induced hepatocellular damage ME1 NLRP3 IL13 CISD3 BCL2 NOS2 TNF CYP2E1 FADD GSDMD BAX PMC11816580__F3 Downstream signaling in regard to the promotion of liver fibrosis by CS CS TIMP1 COL3A1 MMP2 WNT4 SMAD2 GSK3B SMAD4 DVL2 TNF COL1A1 STAT3 PMC7611882__F4 Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation ACAD8 NAGK HAL ASPH HACD4 EXT1 POR DGKG PLAT CYP26B1 ALG2 POLA1 ADSL B3GNT5 ACO2 BST1 HEL-S-111 ESD CAD ARG1 PGAM1 CERS2 MAPDA LIAS GUK1 PISD MTHFD1 HEL-S-87p DBT POLD3 DPM3 ASAH2 DPM1 PSAT1 ELOVL7 SUCLG1 ADPGK CHKB COASY ECHS1 ACADM PNP ALDH2 CERS6 PMC5129526__F1 Transcriptional regulation of glucose metabolism during active TB disease and in PBMCs stimulated with Mtb PARP14 CS FACL4 LAMTOR3 PARP10 PFKM MTOR HEL-S-32 MDH2 HEL-S-26 ACSL5 IL18 FH ACSL1 SUCLG2 DLAT PGAM1 HEL-S-133P SDHD HK2 SDHA HEL-S-281 SDHB ENO3 SDHAF1 P4HTM PFKL HEL-S-87p PDK4 IDH3B IRS1 HEL60 HEL-S-162eP HEL-S-68p HEL-S-49 NDUFB1 PARP12 PARP11 PDK3 ENO2 SUCLG1 SUCLA2 ACLY ACSL3 PMC4222074__F4 Network links between 23 genes in pathway of mismatch repair and three driver genes RNF7 RPA3 RPA1 LRIG1 LRIG3 LRPPRC SSBP1 POLD3 PMS2 PMS1 MLH3 MSH3 LMO7 PMC12141845__F1 Canonical Wnt signalling pathway with osteokine and pro-inflammatory marker inhibitors SOST LRP5 LRP6 PMC8550759__F8 RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy RNF43 BRAF ROR2 ROR1 PMC9277259__F1 EMT in the DNA damage response, double‐strand break repair pathway choice and its implications in cancer treatment PALB2 RIF1 FANCD2 BLM SHLD3 SHLD2 SHLD1 BARD1 PARP1 PARG BRCA1 PARP3 APLF PAXX RNF8 ATM TWIST1 BRCA2 PARP2 DUT RAD52 RAD51 ERCC1 ATR PMC5888819__F1 Dysregulated genes and their associated microRNAs in the KEGG MAPK-signaling pathway in colorectal cancer NLK CDA ME2 MOS MAX GRB2 TBCA GCK BDNF PMC1525228__F9 Diagram depicting the mechanism by which NGF may inhibit GSK-3B and promote axon growth NGF GSK3B PTEN BDNF PMC8096351__F8 Identification, Biological Activities and Biosynthetic Pathway of Dendrobium Alkaloids MVD MVK IPP COCH PMC3170890__F1 IL-10 signal transduction and hypothesized treatment by dual gene therapy SET STAT3 PMC5869528__F9 Toll-like receptor signaling pathway CD14 CTSK TLR9 TRAF3 TRAF6 IRAK4 IRF3 RAC1 TLR3 CPO TLR4 LBP CD40 FADD TIRAP PMC4169706__F2 Genome-wide association analysis of anti-TNF drug response in rheumatoid arthritis patients KCNA5 SLC25A13 COL13A1 WIPF1 BMP5 C6 RGS20 PRKG1 DAB1 RORA CHRNA3 LINGO1 PMC4701046__F2 Signaling pathways in melanoma NF1 BAD BRAF NRAS CCND1 PTEN MTOR CDC42 PMC4148370__F3 Differentially expressed genes (DEGs) in the T-cell receptor signaling pathway ITK FYN BCL10 LCK ZAP70 GRB2 CDK4 LAT CBL PMC4148370__F2 Differentially expressed genes (DEGs) in the B-cell receptor signaling pathway BTK BCR DAO BASH CD22 LYN SYK CD81 CD19 PMC2854193__F1 Autophagy Genes as Tumor Suppressors TSC2 TSC1 ATG12 ATG3 AMBRA1 ATG101 PTEN UVRAG ATG10 MTOR PMC11201619__F2 Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model GSTM2 SNCA KEAP1 PMC3759859__F2 Oncogenic role of the AKT signaling pathway TSC2 RICTOR BAD TSC1 MDM2 PTEN MTOR RHEB PMC3759859__F3 p53-induced cell cycle control and apoptosis ATM MDM2 ATR BAX PMC3759859__F4 Interplay between p53 and AKT/mTOR in regulating autophagy TSC2 TSC1 ATM PTEN MTOR ATR RHEB PMC6102891__F7 Signaling pathway of OS and pregnancy (a brief view) BCL10 KEAP1 FOXO3A GCLC PMC9331760__F4 HDACs in the Response of Cancer Cells to Cellular Stress and the Potential for Therapeutic Intervention MAF HDAC3 KEAP1 HDAC1 SIRT1 BACH1 PMC3359119__F1 mTORC1 signaling and regulation of pancreatic Beta-cell mass EEF2K GSK3B RALA PTEN EIF4E MTOR DEPTOR IRS1 NR1C1 RHEB TSC2 RICTOR TSC1 MAP4K3 EIF4B PMC4403188__F6 GAi1/3-mediated activation of TLR4 in response to LPS CD14 TLR4 RELA TRAF3 LBP IRF3 IL6 MYD88 IL1B PMC9213371__F1 NFKB in control of regulatory T cell development, identity, and function F8 RELA RELB FOXP3 PMC7917472__F4 PI3K-Akt signaling pathway regulated by EZP NPB BAD MEI1 PTEN EIF4E MTOR RXRA TSC2 BCR FRK MDM2 SYK RAF1 RBL2 CD19 PMC3612853__F1 Signaling and transcriptional regulation of Th17 polarization IL21R RUNX1 MTOR IL23R FOXP3 BATF IFNG STAT1 RARA AHR STAT4 RORA IRF4 GATA3 STAT3 PMC10398793__F4 In the IPA data software the disease and function analysis of the RNA sequencing data from Primbio GSK3B MYC CXCL8 MAP1LC3A HIF1A MTOR ESRRA HSF1 FOXO1 MAPK12 H1-2 MAPK1 CP PMC6912474__F2 Organelle homeostasis imbalance signaling pathways ATF4 EIF2A MLX XBP1 PMC4848680__F4 Eicosanoid synthesis pathways: Arachidonic acid is a polyunsaturated fatty acid that is released from the cellular membranes by cytoplasmatic phospholipase A2 (PLA2) COX1 LTB PMC3482945__F3 Pathway related to prostate cancer MCCC2 ADIPOR2 FECH NEK3 PARM1 STK35 SFN SRM DGKZ PHKA2 PMC3696647__F7 Schematic diagram for HIF-1A functions in cap-dependent translation of selective mRNAs, cell proliferation, and tumorsphere growth of cancer cells in low O2 environment TSC2 TSC1 MTOR EIF4G1 EIF4E3 RHEB RBM4 PMC7162614__F6 Adding MASP1 to the lectin pathway—Leprosy association puzzle: Hints from gene polymorphisms and protein levels FCN3 TG CR1 PMC12144611__F3 Decoding CD24: Roles of chemoradiotherapy resistance and potential as therapeutic targets PTEN GIT2 ARF6 STAT3 CD24 PMC8776696__F4 Transcriptomic profiling reveals gene expression in human peripheral blood after exposure to low-dose ionizing radiation CTSG HBA2 OAS3 HLA-G HLA-DQB2 ORM2 HBB B2M OCM NDUFB6 HLA-DQA2 PMC7661869__F1 ARHGAP24 inactivated Rac1/Akt/NFKB in acute pneumonia ARHGAP24 RAC1 IL1B PMC9422807__F2 Comparing the Cytokine Storms of COVID-19 and Pandemic Influenza CXCL10 IL22 CXCL9 TNF CCL3 MAL PMC3136090__F5 Signaling schematic representation: The postulated signaling pathway involved in this study CDK2 RHO TUB PMC7515907__F3 Interconnections between cilia, aging and Alzheimer’s disease genes DNAAF2 BBS2 GSK3B PAXIP1 DNAJB1 SPAG1 RB1 DRD2 HMOX1 PDPK1 TP53BP1 GATA1 PRKCA TSG101 ARL13B IL16 A2M NPY PTK2B RPGRIP1 MDM2 RAD51 APOE IFT20 BAK1 FOS PSEN2 VEGFA ENO1 TNF BRCA1 HTRA2 CALM1 HEL-S-49 RICTOR HEL-S-80p PTCH1 GRB2 BCL2 TERF1 BLMH TF TERT BACE1 EIF2S1 EGFR INS NPHP1 DHCR24 EEF1A1 VPS4B IFT140 DYNLRB2 CLU PRNP INSR BBS7 IFT57 BBS5 BBS4 BIN1 PKD1 MCHR1 CDC2 JUN BAX CBY1 RPA1 PMCH NR3C1 VPS37A DYNLT3 ZMYND10 CCDC40 NR1C1 PDCD6IP DRC7 DNAH14 RSPH3 CASP3 NFKBIA EP300 SLC2A4 STUB1 PSEN1 TRAF3IP1 CDK3 DNAH7 PPARG IFT81 SHC1 PMC8956889__F2 Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone CDC6 ORC6 ORC1L CDT1 DBF4 ORC3 CDC45 ORC2 PMC4910530__F1 Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD TBK1 CHMP2B WDR41 TMEM106B C9orf72 VCP PMC5861487__F3 TGFB pathway BAMBI E2F4 NODAL SMAD6 SMAD4 SKP1 ARHA TNF RBX1 LTBP1 IFNG FST THBS1 SP1 SMAD1 PMC2874810__F3 Ingenuity Pathway Analysis Network EREG CCR2 MXD1 SOCS3 NFKBIZ ZFP36 HEL-S-11 FOSB JUNB RAP1GAP HOXB13 NPHS2 NAMPT AREG PVALB NGL1 PSAP CSTA EGR2 CXCR4 GRIA4 DUSP2 IFIT3 SDCBP EGF CASR KCNV2 TNNC2 GPS2 TLR7 RGS1 CPVL IL1B SGK1 KLF6 PER1 EGR1 PTGS2 IER2 CXCL2 TRIM29 SLC16A3 CNTNAP3 RASGEF1B CD59 NFKBIA FAM167A TRIB1 OSM CYCS CCL3 PMC8307213__F6 Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis MFN1 PINK1 SIAH3 OPA1 PMC4281589__F1 Retinoic acid (RA) synthesis pathway in the gut TLR5 CD80 PMC8493399__F8 Cyy260, a novel small molecule inhibitor, suppresses non-small cell lung cancer cell growth via JAK2/STAT3 pathway CASP3 MTOR STAT3 BAX PMC3246074__F2 Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance MYD88 PMC6689321__F3 Cross-talk between the CDK4/6 and mitogenic signaling pathways in cancer TSC2 TSC1 GSK3B GRB2 CDK4 CDK6 RHEB PMC4288257__F5 Malonylated proteins in glucose and fatty acid metabolism pathways ALDOB FBP1 HMGCL HEL-S-32 HEL-S-68p ACAT2 HEL-S-162eP HEL-S-26 ACSL5 ACAT1 PC FH ACSL1 ACSF2 ACLY ACD HEL107 PGAM1 HEL-S-133P EHHADH PGAM2 PYGL FABP1 GPD1 PMC7261485__F9 ATP11B deficiency leads to impairment of hippocampal synaptic plasticity MAPK14 ARC SYP DLG4 PMC7427992__F7 TG-resident HSV-specific memory CD8+ TRM cells downregulate the T cell exhaustion associated pathway and confer protection from ocular herpes in HSV-1 infected asymptomatic humans and HLA transgenic rabbits CXCR3 CCR7 CD44 TIGIT LAG3 TG CD69 PMC5216743__F6 Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells TSC2 BTK TSC1 TLR4 EIF4E PMC3994729__F4 Expressional regulation of genes linked to immunity & programmed development in human early placental villi CDNF TYK2 JAK3 JAK1 STAT3 PMC7542157__F2 Molecular mechanisms of NADPH homeostasis in cancer MTHFD2L ME1 HEL-S-26 ME2 GOT2 DHFR GLS2 NNT MTHFD1 ME3 MTHFD2 HEL-S-32 PMC9710037__F2 Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process ERBB2 EGFR GRB2 PMC4815038__F8 ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies ELF2 ATF4 BCL2 MCL1 DDIT4 PMC7987945__F6 Transcriptome Analysis of Ovarian Follicles Reveals Potential Pivotal Genes Associated With Increased and Decreased Rates of Chicken Egg Production RPLP2 DLG4 PRNP GABRB3 NDUFB10 NPL NDUFA11 NDUFS4 NDUFS6 NDUFB9 NCAM2 DLG2 NDUFAB1 NDUFS3 GABRB2 NCAM1 KCNF1 NDUFC2 GABRG3 TRIP12 GTF2E2 LRRTM3 GABRE GABRB1 FANCL D2HGDH CACNB1 PMC5764779__F4 Pathway affected commonly in liver metastases irrespective of cancer types CD14 COX2 THSD4 PSD2 PLEK TNF PMC6200414__F3 Phospholipid-binding tumor suppressor ANXA7 linked to the interrelated FGF8 and cyclin E pathways through Ca/phospholipid signaling in prostate cancer SRI MAPKAPK2 HGF EGFR SOST FGF8 CRAT PTEN RAC1 HRAS GAST CBL CCNE1 SPR IGF1 PTK2B GRB2 CYP1A1 BDKRB2 CP STAT3 PMC7905841__F1 Ceramides in Metabolism: Key Lipotoxic Players UGCG CERS3 LASS1 CERS5 KDSR CERS2 CERS6 PMC6850018__F1 Modeling therapy resistance via the EGFR signaling pathway MAX GNB5 EGFR PTEN MTOR PMC4495601__F7 Novel drug target identification for the treatment of dementia using multi-relational association mining CD14 NLK MOS NGF DAO MAX FLNA GRB2 ECSIT TRAF2 ERI1 PMC6936066__F8 The explanation of TGFB regulates cell fate and plasticity as well as multifunctional cellular responses via SMADor non-SMAD pathways or ITGB1 pathway band with fibronectins and tenascin-C PI3K/AKT pathway HEL-S-28 ITGB1 PMC4200801__F3 Current strategies to generate tolDCs IL10 CD40 IL6 CD80 MTOR GATA3 PMC3816662__F1 PI3K/Akt/mTOR signaling pathway BAD MYC PTEN EIF4E MTOR RHEB MLST8 TSC2 RICTOR TSC1 MDM2 CCND1 BCL2 PMC4040939__F2 Wnt pathway, sclerostin, and DKK1; effects of monoclonal antibodies on bone.(a) Scl and DKK1 bind Wnt coreceptors LRP5/6 to inhibit Wnt binding and signaling to decrease bone formation LRP4 LRP5 LRP6 DKK1 PMC2692251__F2 HuR and/or AUF1 differentially regulate mRNAs encoding cell cycle and Erk1/Erk2 Mapk signaling-related genes in MCT-1–transformed cells SOST SHE PMC7933428__F7 Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics KEAP1 ELL PMC10929203__F1 Exosomes in psoriasis pathogenesis IL36G IL6 TNF PMC10931608__F11 Signaling pathways involving MISP OIP5 MISP STAT3 PMC8267809__F1 Activated PI3Kinase Delta Syndrome—A Multifaceted Disease BCR IL7R CD40 PTEN IL6R CD19 PMC3346900__F4 (A, B) Schematic view of the Fas/Fas-ligand (FasL) apoptotic signaling pathway HTRA2 BAX PMC3236216__F8 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways CCR5 SDCBP CTSS SOCS3 ATG3 TNFAIP6 ETV6 NCF4 NFKBIZ ATP6V1C1 TNFSF13 MYD88 DSC2 CEBPB MX1 IFNG CEBPD TXNDC12 LCP2 IL18 CFD PTK2B PICALM ETS2 NR1H3 CD14 SDHC LYZ IRF9 VAV1 IL1RN AIF1 KLF5 FES ATF3 GADD45A IRF3 CYBB SPI1 RELA TNFSF10 MPZL1 MCL1 RAB5C ABCA1 NCF1 LMO2 CASP4 PMC6593294__F1 Possible pathways underlying the DLL1/Notch signaling pathway defect MAML1 RUNX2 ATF4 SMAD2 ADA SHH NOTCH1 SNW1 ADAM10 SMAD1 ADAM17 PMC8679799__F1 Human NLRP1: From the shadows to center stage NLRP1 DPP9 IL1B GSDMD PMC9323564__F16 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients NDUFB11 ATP5MG NDUFA12 IDNK NDUFB10 DLD OGDH COX6A1 UQCRHL HEL-S-162eP PMC9589221__F6 Melatonin signalling in Schwann cells during neuroregeneration SHH GDNF BDNF PMC5553784__F3 Reactome functional interaction network corresponding to 520 genes showing differential expression in the T0 (fasting) vs T2 (7 h after eating) comparisons BOC TWIST2 SCO2 MYH10 RPL35A UBB SOX9 CCR1 NLRP3 TLE4 RPE RPS20 CREB5 PPIE MMP25 HIRA CASC3 IRF2BPL ATF3 CHAC1 PPIF THBS2 CREM TJP3 RND1 BARX2 TANK C1orf51 DKK2 BCL2L11 MYH2 HDAC5 CEBPD HMGN1 ABCC6 GATA3 SELE PER2 SLC27A4 TIAL1 MAFF HECW2 KLF5 PBX1 HEL-S-69p EED SDC4 MAPK4 NR4A3 DBP ABCC1 CLDN7 HECW1 NFE2L3 TXNIP SKP2 EPHB2 TIRAP SOCS1 CYCS RPS21 PMC6121269__F2 Pathogenicity and factors associated with the disruption of the normal cellular activity APC ARHA PMC5669051__F4 Endocannabinoid System in Neurodegenerative Disorders GIP LPA GAA AMT PTPN22 PMC9323564__F13 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients TH FLCN PTEN SLC3A2 TNF MTOR SKP2 PMC12174527__F2 Metabolic Pathway of RFC SHMT1 DHFR MTHFD1 HEL-S-51e PMC5050510__F4 Repeatability of cortisol stress response in the European sea bass (Dicentrarchus labrax) and transcription differences between individuals with divergent responses HEL-S-62p CD9 F10 CS PLG F8 C4A CPB2 C9 PC A2M F2 F5 FH F3 VWF F11 F7 CR2 PMC5669051__F1 Endocannabinoid System in Neurodegenerative Disorders ARC RAF1 BDNF PMC5904274__F3 Molecular mechanisms of ZIKV underlying the neuropathogenesis STAT1 TSC2 STAT2 IFITM3 IRF9 F3 TYK2 PTEN JAK1 MTOR TRIM25 RHEB PMC2796113__F2 Models of Merlin-dependent membrane receptor distribution in flies and mammalian cells EGF NF2 EGFR NHERF1 PMC8114846__F2 Review of Recent Research on the Role of MicroRNAs in Renal Cancer TSC1 DKK3 TRIM21 VEGFA SMAD4 RIPK3 TRAF6 PTEN DKK1 MTOR PMC5471068__F2 Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse EPOR MYC MDM2 RAC1 MTOR STAT3 PMC3917509__F1 The multiple roles of protein ubiquitylation TRAF6 POLN H2AX PCNA PMC6977568__F1 HER2 signaling pathways in cancer cell and cardiac myocyte NRG1 PER2 PMC11351910__F7 Wnt/Beta-Catenin signaling pathway and miRNAs in pancreatic cancer APC GSK3B MYC LRP5 LRP6 PAF1 PMC7705175__F1 Autophagy-lysosomal pathway (ALP) CTSL HEL-S-130P PMC7069334__F1 Simplified Galactomannan biosynthetic pathway in coffee seed GAL PMC3402068__F1 What Goes On Must Come Off: phosphatases gate-crash the DNA damage response ATM RTEL1 BRCA2 SLX4 MDC1 EME1 MDM2 RAD51 ATR H2AX BRCA1 PMC4651738__F8 Schematic diagram illustrating the proposed signaling pathway MPO FIG4 TNF PMC3022727__F6 IPA pathway graphical representation of Aryl Hydrocarbon Receptor Signaling CCNA2 GSTA4 NR3A2 RB1 HSPB3 CDKN2A CDK6 CCNE1 MGST2 RARB AHR POLA1 NR1B3 GSTT2 GSTA3 MED1 GSTM3 NFIA LOC51064 GSTM5 CDKN1B GSTM1 HEL-S-53e ALDH18A1 HEL-S-21 CHEK1 MGST1 CDKN1A NFKB1 ALDH1A3 DHFR PMC3059560__F1 Targeting the embryonic gene Cripto-1 in cancer and beyond HEL-S-62p NODAL PMC11351910__F3 PI3K/AKT signaling pathway and miRNAs in pancreatic cancer EGF MUC4 EGFR PTEN MTOR PMC3022001__F12 Schematic representation of effect of depletion of the syntaxin-5 complex on the autophagic pathway SEC22B SNX5 PMC2819159__F2 Obesity, Diet and Risk of Non-Hodgkin Lymphoma MTR DHFR TYMS PMC11351910__F4 KRAS signaling pathway and miRNAs in pancreatic cancer EGF EGFR GRB2 SPRY2 PMC11351910__F5 JAK/STAT signaling pathway and miRNAs in pancreatic cancer EPO MYC NMI NOS2 SOCS6 PMC11351910__F6 TGFB signaling pathway and miRNAs in pancreatic cancer SMAD2 SMURF2 SMAD4 PMC4373477__F1 Simplified diagram of the Ras/ERK pathway and SST effects through PTPs, SHP-1 and SHP-2 TSC2 SST TSC1 GRB2 ATF1 CCND1 SRC PMC4373477__F2 Simplified diagram of PI3K/Akt pathway and SST effects through PTP SHP-1 TSC2 SST BAD TSC1 CCND1 BAX PMC6122736__F7 Mechanism of XWL-1-48 inhibits growth of breast cancer cells ATM MDM2 H2AX BAX PMC9173833__F35 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 IL13 IL6 TNF IRF-1 PMC4544746__F7 STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES ID1 HES1 PMC6770389__F1 The infectious spleen and kidney necrosis virus (ISKNV) induced the changes of glucose metabolism FH CIT PDHX RPE MAL PMC4615001__F2 Mitoribosome assembly lines SPG7 DDX28 MTG1 MTG2 HEL97 RBFA PMC5797605__F1 mTOR signaling during autophagy TSC2 ULK1 TSC1 TFEB DEPTOR RHEB PMC5797605__F2 mTORC1 and mTORC2 complexes TSC2 TSC1 MTOR DEPTOR NR1C1 RHEB PMC5882221__F2 Ubiquitin-mediated regulation of the core Hippo pathway components AMOT RNF146 LATS1 WWP1 FBXW7 YOD1 CUL4A LATS2 NEDD4 AMOTL2 USP9X SIAH2 HERC4 ITCH PMC9406970__F2 Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer GFAP PHLPP1 PMC8076600__F4 Cytoskeleton Dynamics in Peripheral T Cell Lymphomas: An Intricate Network Sustaining Lymphomagenesis HELLS VAV3 PLK1 ALK VAV1 ARHA RAC1 MTOR AURKA RHOU ICOS CDC42 PMC7917105__F4 Genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume SI CAD PMC5078608__F7 Ca2+Signaling Pathway Proteins that Are Regulated by Homeostatic ScalingIntracellular signaling pathways PRKCE PPM1E PPP3CA MAPK8 ARHGAP32 EGFR MAPK3 ARHGAP12 CACNB4 STK24 STIM2 ERBB4 BCR MAP4K3 CACNA2D2 HPCAL1 FOS CACNA2D3 ATP2B1 HEL-S-31 PPM1H PPIF GNA11 TIAM1 PLCB4 EDNRB PRKCB NFKB1 CHRM1 ATP2A2 ARHGAP21 GNAS MAPK8IP3 MYLK STIM1 WWOX ADCY9 PMC6913443__F2 Multifactorial regulation of hepcidin expression in hepatocytes TLR4 BMP2 SMAD4 HFE IL6 SMAD1 DKFZp781O1323 TFR2 STAT3 PMC5985159__F1 Acquired Resistance to Drugs Targeting Tyrosine Kinases EGF IGF1R HGF IGF2 PTEN MTOR DEPTOR IRS1 RHEB TSC2 TSC1 IGF1 GRB2 CASP9 PMC8773742__F1 Recombinant Proteins-Based Strategies in Bone Tissue Engineering BMPR2 LEF1 WNT3A RUNX2 BMP2 APC WNT5B SP7 SMAD1 DKFZp781O1323 BMP4 PMC8870354__F2 Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma SLC7A11 ATF4 TRAF2 XBP1 PMC5994557__F1 Specific microRNAs (miRNAs) in T helper 17 (Th17) cell differentiation and targets for current treatments IL21R SMAD2 SMAD4 TRAF6 PTEN ACHE IL23R FOXO1 AHR DNAJA2 OGT TOB1 GFI1 IRF4 STAT3 CDC42 PMC7431833__F6 Schematic diagram depicting the possible mechanisms BACE1 SIRT2 APP PMC8087485__F1 Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine CYP2E1 PMC7848966__F4 Crosstalk of the NF‐KB pathway involved in glioma angiogenesis with other signalling processes TNLG1B EBP TNF TRAF2 PMC7505114__F3 IVM-induced PAK1/Akt/mTOR-mediated autophagy.IVM promotes degradation of PAK1 by ubiquitination/proteasome pathway, thereby inhibiting the Akt/mTOR signaling pathway HEL-S-62p PAK1 MTOR ATG14 PMC10930821__F6 Enhancement of drug sensitivity via molecular therapies targeting tumor growth and antitumor immunity CDK4 CD80 CDK6 PMC7505114__F5 PAK1 cross regulate multiple signal pathways.RAS activation directly initiates PAK1, MAPK and PI3K/Akt pathway PAK1 MTOR PMC10930821__F5 Molecular mechanisms of immunogenic cell death and tumor-specific immune activation via unfolded protein response (UPR) activation by anticancer drugs HMGB1 TLR4 P2RY2 P2RX7 ATF4 FPR1 IFNG PMC10930821__F3 Summary model for the c-Jun N-terminal kinase (JNK)/c-Jun/activator protein 1 (AP-1)-mediated signaling pathway in anticancer drug-induced cell death BAX PMC11772327__F1 Proposed biosynthetic pathway of LC‐alkanes pentadecane and heptadecane in Pogostemon cablin CER1 MCAT PMC5584126__F8 CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors SOX2 LCK ROR2 CD55 BRCA1 PMC10930821__F1 Common intrinsic and extrinsic apoptotic signaling pathways induced by anticancer drugs TRADD HTRA2 FADD BAX PMC4052759__F1 Autophagy regulates p62/SQSTM1 levels to control multiple pro-oncogenic signaling pathways ULK1 ATG12 KEAP1 ATG101 MTOR DKFZp686F0183 PMC4742205__F7 INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma GSK3B INSM1 SHH PMC7994325__F2 Importance of ICOS+ Th1 cells in ICI therapy APC CTLA4 ICOS IFNG PMC7470804__F8 Proposed mechanisms for the GluOC therapeutic effects on hyperglycemia and hepatic steatosis in KKAy mice GSK3B TG FOXO1 PMC7378634__F1 Cellular sources and effects of IL-22 STAT1 TYK2 STAT3 PMC10525260__F3 Multi-Faceted Role of Cancer-Associated Adipocytes in Colorectal Cancer LIN28B PDE3B CXCL1 PRDM16 WNT3A UCP1 CXCL2 TNF HEL-S-104 WNT10B STAT3 PLOD2 PMC4826209__F6 WWOX modulates the ATR-mediated DNA damage checkpoint response ATM SSB ATR WWOX ITCH PMC8721139__F1 Potential of Ferroptosis-Targeting Therapies for Alzheimer’s Disease: From Mechanism to Transcriptomic Analysis VIT GPX4 STEAP3 SLC7A11 NFE2L2 SLC3A2 TF PMC4450766__F5 EGFR pathway and the model of the effect of EGFR/MEK/EGFR + MEK inhibition on the pathway in RAS‐active NSCLC cell lines EGFR RAF1 RPS6 PMC7723971__F1 ROS/NLRP3 signaling pathway participates in sepsis-related immune responses NLRP3 TLR4 IL1B PMC10960420__F12 Patterns of effectiveness of C STAT3 FOXP3 PMC9664061__F1 Promising research direction for colorectal cancer immunotherapy: The regulatory mechanism of CCL5 in colorectal cancer CXCL10 MSC CCL5 TNF CCR1 STAT3 PMC4613973__F8 Working models for the failure of PRL-PRLR-JAK2-STAT5 signaling to activate proliferation in adult human Beta-cells PRLR PRL PMC9999652__F3 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment ITGB4 MYC BNIP3L HEL-S-51e ACLY GAA MXI1 PMC9999652__F7 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment SLC7A5 HEL-S-30 ANXA2 ALOX15 SIX1 TUG1 PMC8641784__F3 SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease SUMO3 PML SUMO2 SENP6 SENP1 SENP2 RNF4 MEF2C SENP3 PMC9999652__F8 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment PDLIM2 PFKL PMC3248866__F2 HPV 16 E5 enhances growth factor signalling pathways EGF EGFR SRC BAX PMC9999652__F5 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment RAB27A MTOR PMC12115344__F1 Diagrammatic overview of key pathways involved in ALD TBK1 NLRP3 CGAS IRF3 STAT3 PMC7971547__F3 Role of inflammasomes/pyroptosis and PANoptosis during fungal infection NLRP3 CARD9 MYD88 AIM2 IL1B IRF-1 ZBP1 PMC7905024__F1 CGAS-STING and TLR9 signaling in response to the recognition of host-derived self-DNA as a DAMP HMGB1 CGAS TLR9 TRAF6 IRF3 IRAK4 MYD88 TIRAP TAB3 PMC9641212__F1 Immune response induced by novel coronavirus infection CASP3 IL33 TNF IRF-1 MLKL PMC6955855__F5 Terpene and terpenoids biosynthesis IDI2 MVK IDI1 IPP PMC11395325__F7 Proposed mechanism by which HAE improves lactation TSC1 PTEN DEPTOR PMC8867093__F2 Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells GPX1 HEL-75 PMC4030844__F1 Simplified schema of interconnections between small ubiquitin-related modifier (SUMO) pathway proteins and other factors regulating androgen receptor (AR)-dependent transcription SUMO3 SENP1 SENP2 HDAC1 PMC4030844__F2 AR-independent promotion of prostate cancer (PCa) cell proliferation and angiogenesis by the SUMO pathway SENP1 CCND1 SP3 SUMO1 SENP3 PMC6102867__F2 Regulation network of circRNAs in cancer FOXO3A EGFR VEGFA E2F5 LATS1 CDK6 CCNE1 CDK2 BIRC3 JAK1 EZH2 FMNL2 STAT3 CDC42 ITCH PMC9523121__F1 Hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review POMC SOCS3 NPY AgRP ATF4 EIF2A XBP1 PMC6433691__F7 Model of JS‐K‐induced anti‐tumour activity in gastric cancer APAF1 HEL-S-44 BAX PMC4633914__F1 Functions and interactions of CIP2A and the “oncogenic nexus” of CIP2A are presented in a schematic representation of the major interacting partners of “oncogenic nexus” of CIP2A protein CIP2A MDM2 PPP2R1A FOXO1 PMC9658791__F3 Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury ATF4 XBP1 PMC5676474__F7 Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos GPX4 NFE2L2 GPX1 HEL-S-44 GADD45A HSPD1 DDIT3 MORF4L2 PMC10968836__F2 Comparison of the signalling pathways triggered by TNFR1, Fas and TRAIL agonist receptors RIPK1 TRADD TNF TRAF2 ADAM17 PMC3956136__F1 Canonical Wnt B catenin signaling pathway APC GSK3B LRP5 LRP6 PMC10968836__F3 TRAIL canonical signalling pro-apoptotic pathway RIPK1 FADD PMC11812559__F2 Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases SMAD2 SMAD4 PMC10968836__F4 DR5 non-apoptotic signalling pathways RIPK1 ATF2 CXCR4 RIPK3 SPHK1 CCL2 TRAF2 FADD MLKL PMC10968836__F5 TRAIL-induced non-canonical pro-tumoral signalling via DR5 secondary complex formation TRADD ROCK1 ATF2 EGFR PTEN RHO CCL2 RAC1 MTOR CPN2 SRC UNK TRAF2 FADD STAT3 PMC6829074__F1 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways TRADD FOXO3A TRAF2 FADD FOXO1 PMC6829074__F2 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways IRAK1 TRAF6 IRAK4 MYD88 IL18BP PMC9043558__F1 Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease FLNA ROR2 ROR1 PMC3929401__F1 Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta STAT1 STAT2 STAT4 TYK2 IFNAR2 JAK1 IFNAR1 MX1 STAT3 PMC4394599__F2 Molecular pathway of glycolysis in NSPCs TIGAR SCO2 MYC ENO1 PTEN PDK4 MTOR HK2 PMC4394599__F3 Molecular pathway of glutaminolysis in NSPCs SLC38A5 SIRT4 MYC GLUD1 GLS PMC3712731__F4 Display of wild-type and disease pathway diagrams PLCG1 EGF LRIG1 EGFR CDC37 PMC5414760__F6 Potential role of CBX2 in the regulation of sex development TSPYL4 TBX2 FGF2 INSL3 PBX1 FZD1 FOXL2 MTM1 SOX9 SRY CBX2 SOX3 WNT4 SF1 TSNAX TEX10 PMC9357883__F3 Molecular mechanisms underlying the role of hypoxia-inducible factor-1 A in metabolic reprogramming in renal fibrosis PTEN MTOR HEL-S-133P PMC10193374__F1 In wound healing, CTHRC1 can recruit additional M2 macrophages to the wound site to promote skin repair and activate the TGFB and Notch pathways ROCK2 NOTCH4 ROCK1 DPAGT1 APC GSK3A ARHA RAC1 MTOR CTHRC1 HES1 HES5 HEY2 GRB2 NOTCH1 SYK PMC7376803__F1 AMH and FSH signaling pathways, cellular outcomes, and main functions in IVF practice SMAD6 SMAD4 AMHR2 FOXO1 TLX2 AMH MMP2 CDK2 SRC FSHR HAT1 SMAD1 DKFZp781O1323 PMC5942524__F2 Organismal Injury and Abnormalities, Cardiovascular Disease, Nutritional Disease Ingenuity Pathway Analysis (IPA) Network MAP2 OPRM1 PTGS2 DRD2 DRD4 CNR1 LTA MAP2K1 SLC6A3 BCR BDNF NTRK2 ABCB1 PMC9554349__F3 Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease DDR1 STAT3 CD36 PMC5942524__F3 Hereditary Disorder, Organismal Injury and Abnormalities, Respiratory Disease Ingenuity Pathway Analysis (IPA) Network IL10 IL1A CRP PMC8375320__F3 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development TRPV4 YAP1 ERBB2 PIEZO1 WWTR1 BMP4 PMC8375320__F1 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development PIEZO2 YAP1 PIEZO1 FLT4 LATS1 WWTR1 LATS2 PMC3881602__F1 Interplay between regulatory T cells and metabolism in immune regulation RICTOR CTLA4 MTOR GATA3 ICOS CD36 FOXP3 PMC6407036__F3 Biomarkers in the Pathways in cancer TH EGF BAD GHB2 GEM POLK SMAD2 APC SMAD4 MTOR POR CBL CASP3 CASP9 MSH3 MSH2 SMAD1 MAL BAX PMC6407036__F4 MiRNAs involve in different types of cancers and colorectal cancer biomarkers DYM ATM ZEB2 APC TP63 CYC1 BCL2 SHC4 MMP16 PTEN SPRY2 SOX4 PMC4553385__F2 Treg suppression IL10 APC CD80 PMC5661628__F1 CS synthesis CSGALNACT1 XYLT1 CHSY3 GAL CHPF CHSY1 CSGALNACT2 B3GAT1 B3GALT6 PMC4621004__F1 RAGE signaling pathways HMGB1 EGR1 SRC ARHA RAC1 LPA CDC42 PMC4306304__F1 Hereditary hemorrhagic telangiectasia is a genetically heterogeneous disorder caused by mutations in several genes in the TGFB/BMP signaling pathway SMAD4 ENG ID1 SMAD1 DKFZp781O1323 PMC8668794__F3 Gene expression and epigenetic responses of the marine Cladoceran, Evadne nordmanni, and the copepod, Acartia clausi, to elevated CO2 HEL-S-61p HEL-S-182mP PMC8148155__F1 Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice FAR1 PEMT PMC7947364__F1 Summary of the cellular metabolic effects of hyperglycemia in cancer IGF1R EGFR GRB2 USP6NL HK2 FASN PMC3774704__F1 Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets IL10 NLRP3 TLR4 PMC2810660__F1 Autophagy and NFKB fight for fate TRAF3 REL TRAF2 PMC5541893__F3 Mechanisms involved in initiation, perpetuation, and resolution of inflammatory responses TH ANXA1 MPO S100A8 FPR2 PMC7564048__F3 Crosstalk with the TGFB/BMP SMAD pathway at focal adhesions (FA) BMPR2 ENG PMC6480119__F9 Schematic diagram of EGCG anti-tumor mechanisms based on reverse docking PLK2 PRKCQ PLK3 MAP2K4 IRAK1 NTRK1 IRAK2 IRAK4 MAP3K5 TNF PARP3 CDK7 IKBKB PIM1 BCR WEE1 APAF1 CDK2 SYK JAK3 NOS2 NTRK2 PMC9143803__F2 New Insights into the Pathogenesis of Giant Cell Arteritis: Mechanisms Involved in Maintaining Vascular Inflammation CD14 CCR2 CX3CR1 CCL21 CD83 CCL2 RAB7A FOXP3 CCR7 CXCL9 CCL19 CD80 CCL18 PMC8466925__F2 Polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis SHBG FSHR LHCGR STAR PMC8554507__F1 Modular map of Bradykinin-mediated inflammatory signaling network CHUK CAST RASA2 VEGFA OSCAR DES MTOR HRAS PTGS1 HEL-S-69p GNA11 RELA GNG2 PIK3CA GNAS PXN GNB1 CLCA4 BAX PMC11101339__F4 KRAS pathway and KRAS inhibitors MTOR PMC11101339__F5 Main mechanisms of therapy targeting TME in SMARCA4-UT APC CXCL9 EZH2 IFNG PMC7056627__F1 LncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/Beta-Catenin Signaling Pathway DKK2 PMC2447903__F8 TWEAK killing TRADD TRAF3 TRAF2 FADD PMC7599155__F2 Dna2 is an essential gatekeeper to HR-dependent restart of stalled replication forks RAD51 DNA2 PIF1 PMC8136122__F5 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) SMAD2 APC PMC8136122__F6 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) EGFR CDCP1 TNF PMC9364940__F1 Ionizing Radiation-Induced Ferroptosis Based on Nanomaterials CGAS GPX4 LPCAT3 FACL4 ATM SLC7A11 PMC8271933__F1 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products TSC2 TSC1 MDM2 BCL2 PTEN RHEB PMC9225571__F1 Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis AREG PMC8136122__F4 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) EGR1 TIMP3 PMC5838215__F1 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder CTBP2 CSNK2A2 CSNK2A1 CTBP1 GSK3B SMAD4 DKK2 SIAH1 DVL2 FZD7 ROCK2 INVS LRP5 LRP6 ARHA RAC1 RBX1 PLCB1 NLK CACYBP DAAM1 CREBBP PSEN1 AXIN1 CSNK2B PMC8271933__F2 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products CSH2 PMC5838215__F2 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder CSNK2A2 PPP3CA GSK3B SMAD4 DKK1 CCND3 SIAH1 FZD7 ROCK2 INVS LRP5 LRP6 CAMK2G ARHA RAC1 RBX1 NLK PLCB2 DAAM1 CREBBP PPP3R1 PRKCB PSEN1 AXIN1 CSNK2B PRICKLE2 PMC8136122__F2 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) HMGB1 SEMA7A ATF4 SMAD2 SIRT6 FSTL1 TGFBR2 SMAD4 NOX4 RHO SLIT2 PMC6230982__F2 Metabolic pathways involved in anticancer drug resistance BRAF GCLC TES MTOR HEL-S-133P PHGDH HK2 FASN HEL-S-281 GLS PMC9028275__F3 Entanglement between Mitochondrial DNA and Tumor Metastasis CGAS PDC ND6 TLR9 VEGFA CCL7 PMC3288605__F2 Pathway of formation and catabolism of HDL particles PLTP LPL ABCA1 PMC2782733__F2 EGFR signaling through the PI3K/Akt pathway EGF EGFR GRB2 PTEN MTOR PMC7760552__F2 Release of TEX and their molecular cargo composition CD9 LOXL2 CD63 IGFBP1 CD44 RHO IGFBP5 PMC7225257__F1 Recent mechanisms of resistance identified in lung adenocarcinoma WEE1 ATM YAP1 BRCA2 SMAD2 PARP1 HCTP4 ATR GDF11 MAST1 BRCA1 PMC7219929__F3 Schematic depicting the response of steroidogenic cells to stressors such as polycyclic aromatic hydrocarbons and ROS KEAP1 SP1 PBR PMC10529884__F1 Report from the 24th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Richmond, British Columbia, 28–29, October 2022 BRAF MSH2 PMS2 PMC9510994__F8 Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of floral scents between two contrasting varieties of Lonicera japonica TES MVK IPP HMGCR PMC10296705__F2 Biosynthesis pathways of isoprenoids and the biosensors that are responsive to isoprenoids and their precursors TUB IPP PMC5917100__F1 Viruses and the Autophagy Pathway C20orf185 SQSTM1 SNAP29 PMC6438930__F2 Therapeutic targeting of glycolysis, lipid and redox metabolism in CSCs CD36 GLS PMC8441355__F6 Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways CYP2E1 NQO1 STAT3 PMC8149954__F1 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization NLRP3 ATF4 GMFG NOX4 IRF3 CCL2 IL1B PMC3268617__F2 Dys–Syn–nNOS pathway and miRNAs coordinate the muscle differentiation program POLA1 PAX7 YY1 HDAC1 PMC3954825__F2 DISC1 as a key lead in studying cortical development and associated brain disorders VLDLR DISC1 ERBB2 ERBB3 APC GSK3B APP NRG1 DAB1 TF PMC3355930__F1 Prostaglandin E2 (PGE2) biosynthesis and signaling COX1 PMC11750270__F8 Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis MAF KEAP1 NQO1 PMC7757125__F9 Metabolic pathways connecting gene expression, DNA methylation, and targeted metabolomic data PDC CS ACACA ACACB PDK2 MPC1 MPC2 DLD MLYCD ACSS2 PDK4 FASN PMC6230982__F1 Metabolic pathways associated with cancer HEL-S-26 GOT2 GCLC F2 FH PGAM1 HEL-S-133P PHGDH HK2 FASN GLS PMC5916355__F5 Proposed model for nicotine-induced synaptic plasticity in the OFC BACE1 NRG3 ERBB4 PMC7002027__F2 Phagocytosis checkpoints as new targets for cancer immunotherapy TLR8 SIRPA CGAS CD47 TLR7 TLR9 LILRB1 IRF3 B2M PMC3996455__F1 Treg functional stability and its responsiveness to the microenvironment STUB1 MYD88 MTOR STAT3 CCL3 FOXP3 PMC10280140__F11 TGF‐B‐induced PI3K/AKT/mTOR pathway ATG3 MMP9 TGFBR1 TGFBR2 MTOR DKFZp686F0183 IRS1 PMC9507923__F2 QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology EGFR APP TNF PMC4734073__F4 Strategies evolved by Staphylococcus aureus to counteract innate immune response HEL-S-62p SCIN FPR2 IL8RB ADAM10 CXCL3 PMC5681734__F1 NRG–ErbB signaling pathway ERBB4 ERBB2 ERBB3 NRG2 NRG1 MTOR PMC11873031__F5 Experimental design, analysis and validation TRUB2 SET PMC2989686__F4 Canonical pathways for cardiovascular disease CPB2 CFB PLG SERPINF2 PMC3025468__F11 Compartmentalization of TNF-R1 signalling and A-SMase activation CASP3 TRADD CASP9 TNF HEL-S-130P FADD PMC5173045__F7 Proteinase-activated receptor 2 promotes TGF-Beta-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGFB type I receptor ALK5 SMAD2 SMAD4 PMC5721944__F2 Hypothetical schematic connecting basal IP3R mediated Ca2+ release to protein translation, via AMPK and the TOR signalling pathway TSC2 TSC1 MCU PMC6914886__F6 The proposed mechanism by which green tea acts against NAFLD RXRB ADIPOR2 TLR4 APOA5 TRAF6 NR1C1 ACSL3 FOXO1 UCP2 HMGCR CD36 PMC6514668__F1 Schematic representation of the autophagy pathway from reference by Seiliez et al ATG12 ATG3 ATG10 DKFZp686F0183 PMC3941218__F1 Insulin- and IGF-1-signaling pathways TSC2 BAD IGF1R IGF1 MDM2 CASP9 TBC1D4 IRS1 PMC7113111__F1 Signaling pathways from three ER transmembrane stress sensors during unfolded protein response (UPR) in schizophrenia ATF4 EIF2A UNK TRAF2 PMC4726830__F3 Emerging targets for glioblastoma stem cell therapy RICTOR GRB2 SRC PTEN MTOR MLST8 PMC4120710__F6 Motility, Survival and Proliferation SRC ARHA CDC42 PMC8149954__F2 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization RERE NDUFV2 GMFG NDUFA9 HEL-S-44 ENO1 SDHD HK2 SDHB PMC8149954__F3 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization HDAC3 SOCS1 PMC12000394__F0 Molecular mechanisms of HBsAg suppression of the IFNB signaling pathway and triggering of early autophagy TBK1 IRF3 SNAP29 PMC11276560__F5 DEGs in selenium metabolic pathways of KEGG metabolic pathway map CTH SELE CBL PMC2566525__F8 Schematic view of part of the IGF-1 and integrin signaling pathway genes transcribed by hNCC POTEH BAD PMC5870602__F8 Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform CYR61 RUNX2 TNFRSF11B COL1A1 SP7 BGLAP PMC11863469__F3 Signaling pathways in GBM ATM APC MDM2 MTOR ATR OTP PMC3335800__F8 MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells TBP RGS4 FOS JUN IL1B PMC8875960__F1 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia BTK BCR LYN PLCG2 CD79A TF PMC8178581__F2 Notch signaling pathway involvement in innate lymphoid cell biology RORC DTX1 TLE4 ADAM10 KLRG1 IL17RB IL23R GATA3 IFNG HES1 PMC3374592__F1 Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles MYC GRB2 SRC PMC8178581__F1 Notch signaling pathway involvement in innate lymphoid cell biology GIG8 ZBTB16 NOTCH1 FLT3 PMC8875960__F4 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia BIRC3 TRAF3 RELB MAP3K14 TRAF2 PMC7726878__F1 TLR-mediated signaling pathways in response to HSV TLR4 TLR9 IRF7 EGFR IRF3 MYD88 TLR1 TLR3 PMC7726878__F2 Responses of TLRs to EBV and HCMV TLR7 TLR4 TLR9 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 TLR3 PMC7704407__F4 Proposed pathways of how cAMP and Ca2+ interact and result in increased AQP4 expression via Gs and Gq/11 in the pathology of HE during ALF TRPV4 AVP AQP4 PMC7214667__F1 Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) signaling pathway and its inhibition with jakinibs in synovial fibroblasts STAT1 MMP3 SOCS3 STAT2 CXCL10 CXCL9 TYK2 TNF OSM CXCL11 OSMR STAT3 PMC8616039__F1 Emerging Therapeutic Landscape of Peripheral T-Cell Lymphomas Based on Advances in Biology: Current Status and Future Directions ALK CCR4 MTOR PMC1852708__F6 Illustration of key proteins in the Rho GTPase signal–transduction pathway, focusing on the KALRN, CDGAP, and MYLK genes NTRK1 ARHA RHO EPHB2 MYLK CDC42 PMC3514620__F2 DNA repair pathways and implicated proteins PALB2 ATM ATRIP MSH6 MDC1 SSB FANCM ATR MPG PMC9606818__F2 Effect of narcotics on ferroptosis-related molecular mechanisms and signalling pathways GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 HEL-S-64p MDM2 HEL-75 LPO SLC3A2 NR1C1 GLS PMC10537080__F2 Critical role of platelet in cancer progression and metastasis MICB VCAM1 MICA CD40 ARHA ADAM17 PMC7982411__F1 MEK-mitogen activated protein kinase–extracellular signal-regulated kinase (ERK) signaling cascade of the mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3-kinase (PI3K)–AKT-serine/threonine protein kinase Akt pathway MAP2K1 NRAS PTEN MTOR PMC6627192__F5 Ingenuity Pathway Analysis integrating differentially expressed genes and microRNAs between imatinib-naïve (IM-n) and imatinib-resistant (IM-r) gastrointestinal stromal tumor (GIST) samples NUSAP1 E2F8 APC CD34 LEFTY2 GINS1 PREX2 UBE2C E2F7 CDC6 MT2A HEL164 MCM10 GINS2 GMNN RBL1 PMC8533171__F8 Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas FLI1 HGF RAB22A MAPK7 APC PTEN UHRF2 RBX1 DDB1 IRS1 FBXW7 DTL CDK6 CCKBR MACC1 IGF1 CCND1 CDK4 RHOB CDC42 SNX1 CCNE2 PMC2720036__F1 Selective Raf Inhibition in Cancer Therapy BAD BRAF PPA2 GRB2 CCND1 SRC BCL2 BAG1 PMC3938170__F1 Folate pathway HEL-S-61p DHFR FOLR1 PMC2078333__F1 Summary of known actions of activated ras-p21 in cells, beginning (top, left) when a growth factor binds to its cell receptor FOS MYC GRB2 JUN PMC3443512__F8 TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN MUC1 EGFR MTOR PMC8303465__F1 Sex Maintenance in Mammals FST AMH WNT4 DMRT1 FOXL2 SOX9 SRY PMC4290704__F1 Signalling pathway and endogenous antagonists of IL-1B and IL-18 IL1R2 MYD88 IL18BP IL1B PMC2577435__F9 Signaling from LMP1 and TLR to IRF7 activation TLR7 TLR9 IRF7 TRAF6 MYD88 TRAF2 PMC1501125__F1 WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability APC GSK3B PTEN TCF4 PMC5890151__F2 Treg likely promote tissue repair and regeneration in a tissue-specific manner AREG EGFR IL33 CCL4 CXCL12 CCL22 CCL3 PMC2720036__F5 Selective Raf Inhibition in Cancer Therapy PIK3R1 PIN1 PRKCZ GNB2 TIMM44 KRT19 MAPK3 MYC NRAS RB1 PRKCA GRIN1 FRS2 SRC MAPK1 OIP5 VAV1 MAPK7 SHOC2 HRAS CRK KRT18 KSR2 YWHAQ HEL-S-80p PAK1 RAP1A GRB2 BCL2 CSNK2B GNB1 PLCG1 PRKCE BAD BRAF HEL2 EGFR RAP2A RSU1 BAG1 DMPK INSR DKFZp686L0365 GNG4 GNG2 NUDT14 YWHAG RFXANK ARAF LTK RBL2 IL2RB SPRY4 RIN1 PEX5L HEL-S-34 NR3C1 RRAS PRKG1 CDC37 RRAS2 PRPF6 SPRY2 LCK HEL164 TBXA2R JAK1 RAF1 CSF1 HEL-S-93 MAPK8IP3 RABGGTB PMC5130114__F1 Disorders of the mTORC1 signaling pathway TSC2 TSC1 PTEN PMC7231083__F1 Type I interferon immune response TLR8 TLR7 TLR4 TLR9 STAT2 TRAF6 IRF3 TYK2 MYD88 TLR3 MAVS TIRAP PMC6731276__F1 Pathway altered on both transcriptomic and epigenomic levels HTR6 PTGIR HRH2 ADRB1 APC GNG7 CALCB CALCRL LHB VIP POMC MC4R GNG2 MC2R PMC7231083__F3 Evasion and inhibition of respiratory virus-induced IFN-I signaling TLR8 TLR7 TLR4 STAT2 IRF3 TYK2 MYD88 TLR3 MAVS TIRAP PMC4728993__F1 Metabolic pathway of phenylalanine (Phe) GOT2 DDC PAH PMC4339543__F2 The Role of the Protein Tyrosine Phosphatase SHP2 in Cardiac Development and Disease GRB2 SRC ARHA INSR PMC139100__F8 Gelsolin-induced epithelial cell invasion is dependent on Ras–Rac signaling PLD2 RAC1 SOS1 ARF6 PIP5K1A PMC4280834__F2 Proposed biosynthetic pathway of diphthamide DPH2 DPH5 DPH6 DPH7 DPH3 DPH1 PMC8447515__F6 Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs IGF1 MTOR STAT3 PMC8847900__F2 Human biosynthetic pathway for trace amines and catecholamines PNMT DBH PMC5569945__F2 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia TSC2 EEF2K TSC1 TBC1D7 CASTOR1 PTEN RPS6 ARF1 EIF4B IRS1 RHEB PMC5569945__F3 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia TSC2 TSC1 TBC1D7 PTEN IRS1 RHEB PMC9290485__F3 Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP1A2 PMC7391788__F7 Ingenuity pathway analysis of genes/molecules that are regulated by thymoquinone in relation to Alzheimer’s disease and inflammation (A), and osteoarthritis and inflammation (B) CD14 MPO BMP2 NBN BCL2L1 TNF HMOX1 CASP3 TNFSF6 TLR4 CDK2 TNFSF10 CASP9 BCL2 CDK4 STAT3 PMC3359641__F3 Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors NGFR HSD3B1 GSK3B GRB2 TRAF6 YY1 MAP3K5 RAC1 HRAS BDNF GHRH BAX PMC8139735__F11 An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia KRT19 SHE BCL2 TF PMC6004395__F3 ABA-dependent signaling pathway in response to temperature stress MYB SNRK MYC ERF PMC4350902__F3 Schematic depiction of PTEN functions in nucleus and cytosol with regard to its posttranslational modifications APC MDM2 RAD51 PTEN NDFIP1 PMC5501692__F3 Human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion DUSP4 EGR1 IER3 FOSL1 SPRY4 FOS MYC ETV4 CCND1 ETV5 SPRY2 PMC7991784__F1 HBV-induced lipid metabolism changes in hepatocytes APOM SCD APOA5 LDLR ACSL1 APOC3 TG SMS NR1C1 HMGCR CYP7A1 PMC7991784__F2 Changes in proteins or metabolites of lipid metabolism pathway affect the life cycle of HBV: potential targets for HBV suppression SQLE PC APOE HMGCR PMC3606625__F1 EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance EGFR PTEN MTOR PCNA STAT3 PMC11766595__F9 TLR4 inflammatory pathway NLRP3 TLR4 ATF2 LBP TRAF6 IRF3 TIRAP PMC9700084__F1 Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury TLR4 NGF CCND1 PMC11936551__F2 LncRNA-MALAT1 acting as ceRNAs and its involvement in the EMT process of retinopathy and regulating the corresponding signaling pathway factors PDE6G IGF2BP3 SAG VEGFA STX17 ATAD2 GUCA1A STAT3 PMC12023943__F4 Keratinocyte differentiation mediated by either CD9 overexpression or calcium stimulation in mouse keratinocytes CD9 LORICRIN PMC10311025__F8 Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response NLRP3 CHAD GSDMD DFNA5 PMC3668835__F4 Genomic landscape of small intestine neuroendocrine tumors ERBB2 PIK3CA SRC FLT3 MTOR FGFR2 PMC10463219__F6 Resveratrol ameliorates insulin resistance by improving insulin signaling via the DDIT4/mTOR/IRS-1/PI3K/AKT/GLUT4 pathway MTOR IRS1 DDIT4 PMC3394947__F1 The proteins involved in the different pathways related to eicosanoid biosynthesis AHR PTGES MGST3 LTC4S PPARG ACOX3 NR1C1 DPEP2 PMC5672917__F1 The role of iron in brain ageing and neurodegenerative disorders CD200 TF PMC4673238__F5 Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells ITK FYN LCK GRB2 TEC JUN LAT CBL PMC8293989__F1 Comparisons of Underlying Mechanisms, Clinical Efficacy and Safety Between Anti-PD-1 and Anti-PD-L1 Immunotherapy: The State-of-the-Art Review and Future Perspectives APC CD80 PMC4216462__F1 TGFB signalling pathway in the early mouse embryo IDI2 NODAL CRIPTO BMP2 SMAD2 SMAD6 SMAD4 ID1 ID3 BMP4 GIG8 SMAD1 GDF3 TF DKFZp781O1323 PMC4741283__F1 IL10/IL10R signaling pathway IL10 CD14 IRAK1 TRAF6 IRAK4 IL6 MYD88 TNF IL6R IL10RB TLR4 TYK2 JAK3 JAK1 STAT3 PMC3702279__F5 Schematic diagram illustrating miR-185 and ATR function in radiation response RAD17 TOPBP1 ATRIP ATR PMC5691663__F1 Thyroid hormone-induced interference with resveratrol-induced antiproliferation is blocked by tetrac and its nanoparticulate analog HMGA2 RRM2 SUMO1 PMC5402749__F1 Necroptosis and Cancer RIPK1 CYLD RIPK3 TNF TRAF2 FADD MLKL TAB3 PMC7041258__F4 Gene expression analysis by IPA software (FC ≥ 1.5 and p value < 0.001) showing nuclear factor erythroid 2-related factor 2 (NRF2) oxidative stress response path design activated in NR8383 cells after exposure to ¼ IC50 of NM403 for 4 h MAF KEAP1 PROX1 PMC5940740__F2 Diabetic stressors lead to Schwann cell dysfunction and neurodegeneration CNTF DHH BAD IGF1 RHO PMC3058235__F1 Control of GnRH secretion by growth factors and small molecules produced by glial cells IGF1 TGFA TGFB1 PMC7564143__F3 Four processes model of cardiac regeneration NRG1 OSM PMC3663490__F5 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer FANCD2 ATM BLM MDC1 MDM2 RAD50 H2AX CHEK1 MRE11A BRCA1 BAAT PMC6237934__F1 PD-1 signal inhibits T-cell receptor (TCR) signaling pathway NFATC1 APC LCK ZAP70 MTOR FOXO1 SKP2 BATF PMC3663490__F6 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer FANCD2 BLM RB1 MRE11A ATM BRCA2 CCND1 FANCM FANCA MSH2 H2AX FANCE FANCG PMC7564143__F4 Simplified overview of the classic Hippo-YAP signaling pathway AMOT NF2 LATS1 LATS2 PMC3638243__F8 The plasminogen (Plg)-dependent pathway of foam cell formation PLG ABCA1 PIGR CEBPB CD68 CD36 PMC7862249__F1 Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities ATG12 ATG3 USP14 TRAF6 ATG10 OPTN DKFZp686F0183 NEDD4 NBR1 PMC6839531__F11 Schematic showing the proposed dynamic changes in the localization of LHCGR, DENND1A.V2, and RAB5B in various cellular compartments RAB5B CYP11A1 LHCGR CYP17A1 PMC6369476__F1 Potential proinflammatory role of resistin in the pathogenesis of osteoarthritis TLR4 TRAF6 MYD88 MAL PMC8533869__F1 TGFB Signaling in the Pancreatic Tumor Microenvironment SMAD2 TGFBR1 TGFBR2 SMAD4 PMC5666889__F2 A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review HEL-S-2a GPX3 GPX4 HEL-S-97n HEL-S-134P GPX1 HEL-S-44 PRDX5 HEL-S-128m PRDX3 PMC3879372__F10 Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells IL10 SRC PLCG2 IRF4 STIM1 PMC6548059__F1 Components of the autophagy pathway reported to be deviated in neuropsychiatric disorders HEL-S-62p ATG3 PMC8458828__F6 Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma AHR TNF PMC8915814__F3 Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics HEL-S-62p CS HEL-S-64p HEL-75 HEL-S-44 PMC6172368__F3 PPI network based on the interaction of the differentially expressed genes between the M2 and M0 groups CDCA5 NFE2 RAB33A CCNA2 CCNH MYD88 IGF2BP2 WFS1 CD1E CYP27A1 CH25H TLR7 CD1A FCER2 CDK14 CCL17 FZD2 CD209 NPL DHRS4 GINS2 ALDH1A2 PFKP FGL2 IRF4 CD1C SLA CD14 GADD45A S100A9 CYBB GLRX TK1 AQP9 CARD9 CDKN1A CLEC4A S100A8 TYMS CCL22 PRKCH WNT5B PPARG SOCS1 PMC5790950__F1 KSHV entry by macropinocytosis and trafficking in the human microvascular dermal endothelial cells TSG101 CHMP6 CHMP5 SRC ARHA PMC6172368__F2 PPI network constructed based on the genes with differential expression between the M2 and M0 groups in the intersection of GSE18686 and GSE35449 ANKRD22 TNFAIP6 CYBRD1 APOC1 IFITM1 CYP27A1 LAP3 MT1E LPL PSMB9 IRF-1 AIM2 CCL8 SCARB1 RSAD2 IRF7 CRABP2 STAT2 CXCL10 SLAMF7 IFI27 HLA-F ISG20 ZNFX1 NCF1 IFIH1 IFIT3 PARP14 IFIT2 BATF2 ETV7 ISG15 GBP1 IL18 XAF1 LGALS3BP MT2A GBP2 TLR5 PTGS2 IL6 IDO1 GPX3 ENPP2 IL27 MT1G STAT4 MT1A GBP4 SOCS1 PSME2 PMC7998878__F3 TRIM8, NFKB and JAK-STAT pathways TNIP3 TRIM8 IFNG STAT3 PMC4859898__F4 mTOR signaling pathway regulated by CDDO-Me in Ec109 cells TSC2 RICTOR PC ELF3 EIF4E MTOR EIF4B RHEB PMC6172368__F5 Sub-networks constructed based on the differentially expressed genes identified in the communities of interest in the protein-protein interaction network using CFinder software IFIT3 PARP14 BATF2 MYD88 GBP1 IL18 TLR7 XAF1 LAP3 GBP2 CD209 FGL2 IRF-1 CD1C CD14 TRIM2 IL6 CYBB IFI27 AQP9 ISG20 TNFSF10 CLEC4A GBP4 SOCS1 PMC6235888__F6 Schematic pathway summarizing the manipulation of GAL via the activation of A7 nAChR to mediate its anti-inflammatory effect HMGB1 SOCS3 RELA GAL PMC7247338__F3 Proposed miRNA–mRNA interaction network of the 10 most abundant differentially expressed miRNAs (DEMs) with their potential target mRNAs MYH9 PPP3CA MYO1C ROCK1 KCNK10 P4HA1 CCDC43 CCDC171 ULK2 MYH10 E2F3 EIF5 BMPR2 IGF2BP3 MAP4K3 MAML2 SP5 PDLIM3 ATG14 ELF2 KIF26A DKFZp666G145 HEL70 MMD FOS EIF4E MBNL1 FAF1 FXR1 KLF4 MYT1L DYRK2 MEF2C CDC73 MYT1 PMC9332480__F4 Multifunctional Role of S100 Protein Family in the Immune System: An Update MPO CCL4 CCL2 CCL3 PMC11624271__F2 General signaling pathway of CLRs from Dectin-1 and Dectin-2 clusters BTK CARD9 BCL10 SYK RAF1 CLEC9A PMC4790585__F1 Wnt/Beta-catenin canonical pathway ROCK2 DAAM2 APC GSK3B ARHA RAC1 DVL3 DVL1 NLK DAAM1 LEF1 DVL2 BCL9 PMC9133079__F3 Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells SOCS3 STAT2 IFNAR2 IFNB1 RAC1 PPP2R1B IFNAR1 STAT1 CLEC2D STAT4 TYRO3 JAK3 MERTK ITGAV JAK1 AXL SOCS1 STAT3 PMC4790585__F2 Wnt cross talk EGF BAD GAB2 EGFR GSK3B MDM2 PTEN MTOR BAX PMC12032345__F1 STING signaling pathwayDNA from damaged mitochondria or pathogens can be recognized by cGAS, and cGAS subsequently catalyzes the formation of 2′,3′-cGAMP TBK1 CGAS ENPP1 DNASE2 TREX1 IRF3 IL6 TNF PMC6771394__F6 Allelic origins of the carotenoid pathway genes TH FOS DES PMC8099721__F1 Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 RAB14 CMTM3 CXCR4 CCNJ FAM83B LIN28A FLRT3 HEL-S-31 PMC6587955__F1 BMPR signaling BMPR2 ACVR1 ACVR2B ACVR2A SMAD6 RHO ID1 ID3 PMC3065765__F3 Iron in regulating the mTOR signaling pathway TSC2 RICTOR TSC1 PRLH PTEN DDIT4 PDPK1 RHEB PMC4539557__F9 This cartoon summarizes our observations and integrates them into the context of previous studies SERP2 SHH BMP4 PMC12040678__F5 Pathogenesis of HMGB1 in alopecia areata HMGB1 TLR4 LRP6 PMC11853802__F2 Schematic diagram summarizing the possible involvement of the GnIH system in endocrine axes and peripheral regulation TH POMC NPY CRH TRH GC PMC8238245__F1 Action of PLK inhibition PLK2 PLK3 PLK4 MTOR PMC12001862__F9 Protective function of DHM on renal oxidative stress, inflammation, and mitochondrial-induced apoptosis by regulating the EGFR/HSP27/STAT3 signaling pathway in CP-induced AKI EGFR STAT3 BAX PMC9166579__F8 Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/Beta-catenin signaling pathway in mice IGF1R IGF1 DKK3 APC GSK3B LRP5 LRP6 PMC4207242__F1 Pathways Modulating GLI1-expression/activity in Cancer EGF EGFR SHH BCL2 SMO TGFB1 PMC4344387__F1 Wnt/Beta-catenin and Notch signaling pathways and pathway crosstalk as illustrated herein RBPJ GSKIP APC GSK3B PMC7079523__F8 Pathway and temporal expressional patterns of oil accumulation PDC PC LPA PMC2526691__F2 Focal adhesion pathway interaction map HEL-S-11 PMC3063577__F2 Simplified diagram showing some of the identified BCR pathway members DOK3 BTK FYN CD72 BASH BIK LCK LYN SYK PLCG2 MTOR PMC6597102__F2 Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation LTA CXCL10 SHH GDNF CCL2 CDH2 BDNF IL1B LTBR APOE PMC8024566__F1 CCR7 and the reactive LN CXCL13 BCR CCL21 CCR7 CXCR5 CCL19 PMC5727251__F4 Inhibitors of the FZD/LRP/Wnt signalling cascade NOTUM SOST LRP5 PMC2691779__F1 Schematic overview of the human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) apoptosis pathway ATM DIABLO FADD PMC6815304__F3 The principal signaling events occurring during fluid shear stress in bone cells RUNX2 SOST GSK3B SRC RHO CDH2 MTOR PMC7382829__F8 Fatty acid metabolic pathways in macrophages infected with Nc-Spain1H versus non-infected cells FER FBL FES FASN PMC7708060__F1 Cellular pathways for DNA double-strand break repair BLM BRCA2 RAD52 RAD51 PARP1 BRCA1 PAXX PMC7382829__F6 KEGG pathway maps represent the NF-ƙB signalling pathway in which DEG in (a) bovine macrophages infected with Nc-Spain1H and (b) Nc-Spain7 versus non-infected macrophages are highlighted PLCG1 NGF TRADD DAO TRAF3 TRAF6 COX2 BTK TLR4 BCR ATM BASH IL1B CD14 LTB PARP1 TRIM25 CNTF LTA LCK LBP LYN SYK TRAF2 LTBR LAT TIRAP PMC9421435__F4 Role and Therapeutic Potential of Macropinocytosis in Cancer CXCL1 TPM1 CCL5 IL6 PMC10774482__F1 Canonical signaling pathways of cGAS TBK1 CGAS IRF3 PMC3247754__F3 Simplified view of the glucose sensing mechanisms in S NRG1 TSTD1 PDE12 OTP PMC7544984__F6 Crosstalk between SRSF3 and other splicing regulators in the regulation of gene expression HNRNPL SFRS3 PMC4503753__F7 EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer SOX2 EPCAM FHL2 CD44 BCL2 PMC4979999__F6 Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model IGF1R IGF1 MDM2 PTEN PMC5302553__F2 Efferocytosis in Atherosclerosis IL10 CD47 HEL-S-99n MERTK ABCA1 GAST APOE PMC3833078__F3 In addition to apoptosis, AR may also regulate other kinds of cell death RHO ACD PMC9157596__F4 Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes PIK3CD PIK3R1 CREB3L2 ATF2 PRKAA1 CREB1 EIF4EBP1 MTOR RPTOR INSR KL SESN3 CAMK4 ATF4 ATF6B PRKAG1 PRKAB2 PRKAB1 BAX ADIPOR1 ADIPOR2 PRKAA2 FOXO3A ADCY1 EIF4E HRAS PIK3R3 ADCY3 IRS1 FOXO1 CREB3 RHEB TSC1 RPS6KB2 ADCY6 STK11 PIK3CA PRKAG2 SESN1 SESN2 PPARG PIK3R2 RB1CC1 APPL1 ADCY9 PMC7401857__F10 Pro-inflammatory signaling molecules release upon HMGB1 stimulation and its receptor blocking HMGB1 TLR4 PMC4043871__F2 Testosterone signaling pathways in Sertoli cells EGFR SRC PMC9674421__F11 Expression and Prognostic Significance of PDIA3 in Cervical Cancer UBC UBE2G2 ATF4 SVIP SKP1 BAX PMC9642324__F1 Immunomodulators: still having a role? RAC1 TPMT NUDT15 PMC8538681__F1 Nucleotide Pool Imbalance and Antibody Gene Diversification ADA NDP PNP PMC5962346__F1 Molecular targets for therapy in the HH pathway web of collaboration HHIP EGF SUFU CCND1 SMO LATS1 LPA TNF MTOR CCNE1 PMC8421901__F3 Underlying mechanism of sorafenib resistance in hepatocellular carcinoma: a bioinformatics study based on validated resistance-related genes KL MAX APP RAN COMP MAL PMC8269379__F1 New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent ASMT AHR CYP1B1 AANAT PMC5559174__F8 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome ATG16L1 ATG12 ATG3 SQSTM1 LAMP2 BCL2 STX17 MTOR DKFZp686F0183 NBR1 WDFY3 PMC12040678__F2 Pathogenesis of HMGB1 in vitiligo HMGB1 CXCL16 TLR4 CD80 CXCR6 PMC11959080__F2 Subcellular localization and proposed molecular mechanisms of ZNFX1 NLRP3 ZNFX1 MAVS PMC12040678__F3 Pathogenesis of HMGB1 in psoriasis HMGB1 TLR4 CD80 IL23R PMC5559174__F7 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome BAD MYC RHO FYN ATM CD2 MDM2 SRC UNK CCND1 RBL1 BAX TCF3 CRK IRS1 BRCA1 FOXO1 CBL LEF1 MAX SUFU BCL2 ATR FADD CYCS TCF4 PMC5559174__F4 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome SIRT2 RB1 HIF1A HSF1 SIRT3 RARA RARB TUBA1C SIRT4 NDUFA9 SDHA RBL2 RBL1 FOXO3A PARP1 SLC25A6 TSC2 TUBA1A SIRT7 ACADL DCP2 TUBA1B HCRTR2 PPARG SIRT1 CYCS PMC3375679__F2 Environmental regulation of GSC proliferation at developmental stages of the gonad AAK1 GSC GAS1 PTEN NOS2 VRK1 PMC5559174__F5 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome HMGB1 CASP12 EPO BLM FTL MRE11A UBB INSR MAF ATM VCAM1 ATF4 GRB2 UNK PPIB LPP HOXA10 JUN CP SELE PMC5559174__F2 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome RHO EIF4E MTOR RHEB INSR TSC2 RS1 RICTOR TSC1 PC ELF3 RPS6 EIF4B PMC5559174__F3 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome EGF TANK NGF TRADD GSK3B RELB TRAF6 PLCG2 MYD88 UBE2V1 TBP HEL-S-71 MAP3K7IP1 HDAC1 CARD11 LTA LCK ZAP70 CD40 TGFA TRAF2 FADD LTBR TIRAP TAB3 PMC4790585__F7 General role of the proteins used for in silico experiments APC GSK3B NKD2 PMC5487560__F1 The kynurenine pathway of tryptophan degradation HAAO HEL-S-90n KYNU KMO PMC8722298__F2 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer TSPAN8 TGFBR3 BTG2 PMC4382495__F2 Signaling pathways involved in thyroid carcinogenesis and tumor progression BAD BRAF CCND1 MTOR PMC7848457__F9 Proposed model of molecular targets of NSAIDs in enhancing Hsp90 inhibitor cytotoxicity of CD44highK562 cells CD44 MTOR HSF1 STAT3 PMC6413549__F4 Biochemical process networks of the differentially expressed proteins generated by MetaCore™ software using a transcription regulation algorithm HEL-S-1 HEL-S-99n DNAJB1 PROX1 TXN DNAJC3 HEL-S-102 YWHAQ HEL-S-94n PABPC1 PSMC6 DNAJB11 DNAJA2 LPL PSMC4 PMC6613304__F5 Nicotinamide Adenine Dinucleotide (NAD+) Biosynthetic Pathways NAMPT HEL-S-90n NMNAT1 NADK NMRK2 NMNAT2 NMNAT3 NMRK1 PMC5802197__F3 CAD backbone network EREG PIK3R1 UCP1 FLT4 SOST MYC HIF1A LCOR UBB MMP3 FGFR1 POMC KDR BTC MMP2 SAFB NPY HEL-S-44 SP1 NOS2 ANGPT2 GFAP TSLP tal-1 VEGFC LEP TGFA CBLC TGFB1 MUC13 MPO XBP1 CEBPB THRA IL18 EPN1 AHR THBS1 RGS16 SNX1 TRIM2 IGF2 NR0B2 IAPP CBL RS1 GHRL EP300 TFF1 CD40 TRIM24 PPARG OSM SHC1 VAV2 NR2F1 CRKL DCN SMARCA4 CSF2 ADM FOS VEGFA ENG HRAS CRK SDC3 MMP14 VTN GRB2 RETN EGF HGF NR3A2 NCK2 EGFR INS TRRAP TNK2 MTOR ESRRA NRP2 UBC RARA GPC1 JUP CRP PTPN11 STAM2 ELANE NR1A2 JUN NCOR2 LRIG1 PF4 LIF CD44 NRG1 IL6 PRL SPRY2 CNTF SIRPA IL23A NRP1 RELA EDN2 PIK3CA JAK1 PMC6542018__F1 Estrogen receptor (ER) activity in breast cancer - canonical (classical; ligand-mediated) and non-canonical (alternative; ligand-independent) pathways of ER activation FGFR1 NFIB FOXA1 YBX1 FGF3 FGF10 FGFR2 FGF7 PMC8722298__F1 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer LIN28B HMGA2 ACTA2 CMTM4 PMC12208402__F12 Proposed RasV12 singling network leading to cell dissemination RHO RAC1 PMC3110938__F2 Genome-wide dissection of microRNA functions and co-targeting networks using gene-set signatures HGF IGF1 PTPN1 INS RHO RAC1 MTOR PREX1 CDC42 INSR CREB5 PMC7018661__F6 The epithelial–stromal interactions in the tumor microenvironment of GC ZEB2 IL33 SP1 PMC4741792__F6 GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells CXCR4 CXCL12 LCP1 PMC8374895__F9 miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis NLRP3 TXNIP GSDMD PMC9408967__F9 Dentin Particulate for Bone Regeneration: An In Vitro Study RUNX2 APC MSX1 PMC8610981__F1 Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease IL6ST STAT3 PMC2896914__F2 Multiple genes involved in interferon production and regulation are associated with risk for lupus TLR8 PDC TLR7 TLR9 IRF7 TRAF6 TNFAIP3 PMC4405010__F1 Sessile serrated and traditional serrated pathways BRAF IGFBP7 PMC5760291__F10 Brucella abortus triggers a cGAS-independent STING pathway to induce host protection that involves guanylate-binding proteins and inflammasome activation CGAS IRF3 NOS2 ARG1 AIM2 IL1B PMC6391709__F5 PI3K/AKT/mTOR and ERK signalling pathways associated with cardiac hypertrophy TSC1 PTEN IRS1 PMC6449425__F1 Biosynthesis of isoprenoids in X MVD MVK IPP PMC7367500__F1 Canonical and Non-Canonical Wnt Signaling in Immune Cells ZNRF3 RNF43 APC LRP5 LRP6 ARHA RYK RAC1 GPR49 CDC42 PMC6142582__F2 Targetable molecular features of primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma PTPN1 REL TNF SOCS1 CD19 PMC4725315__F5 Ingenuity pathway analysis showing up (green) and down-regulation (red) of miRNAs involved in ovarian cancer tumor samples when compared to endometriosis samples MAP2K1 MAP2 PMC9100681__F5 Unraveling the Role of Acetic Acid Bacteria Comparing Two Acetification Profiles From Natural Raw Materials: A Quantitative Approach in Komagataeibacter europaeus PDC CS FH HEL-S-162eP PMC4014746__F1 Canonical Wnt pathway ] TBP APC LRP5 CCND1 FRAT1 PMC2739756__F1 Bile acid synthesis CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC9444450__F4 Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis LRRK2 NCL EGFR CAND1 LRPPRC PNN HIF1A TOP2A CFTR IGF1 DIAPH2 CDC5L FRS2 MDM2 CLTC CDC2 RAMP2 FGF7 PMC3204314__F7 Signalling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis SOCS3 PMC5133970__F7 Schematic representation of the proposed TCS pathogenesis model CNBP PMC10093344__F1 Innate immune signaling pathway that recognizes cytosolic DNA in tumor-infiltrating dendritic cells (TIDCs) CGAS IRF3 TNF AIM2 GSDMD PMC2739756__F3 FXR regulation of enterohepatic circulation of bile acid DKFZp666G145 HNF4A FGF19 FGFR4 PMC2739756__F4 FXR-independent and bile acid-activated cell signaling pathways in regulation of CYP7A1 transcription DKFZp666G145 TLR4 NR1i1 HGF EGFR TGFB1 IL1B CYP7A1 PMC10093344__F3 Tumor immunosuppressive mechanism of AIM2 in TIDCs TBK1 CGAS IL18 CXCL10 IRF3 AIM2 GSDMD PMC7813598__F9 The inhibitory effect of black radish extract (BRE) in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells KEAP1 ATF4 IL1B STAT3 PMC3213687__F2 Appearance frequencies of genes in the mTOR signaling pathway TSC2 RICTOR BRAF EIF4E HIF1A MTOR EIF4B RHEB PMC8746472__F3 Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms BCL2 CDK4 BAX PMC6144698__F1 STAT3 activation pathway CNTF EGF SOCS3 HGF LIF OSM TGFA STAT3 PMC6644047__F1 Simplified TGFB signaling pathways NODAL CDK2 SMAD2 MYC SMAD4 ARHA CDK4 MTOR CDK6 PMC3943571__F1 Ras signal transduction CS MTOR PMC8797453__F5 KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer HEL2 MSRA PMC8277821__F8 Schematic diagram of miR-301a-3p based signalling circuit of trastuzumab resistance in HER2-positive GC IGF1R FGFR1 LRIG1 PMC6584407__F7 Signaling mechanism of MUS81 and CyclinB ATM BLM EME1 RAD50 RAD51 CDC2 ATR MRE11A PMC5922678__F1 Alterations in the steroid biosynthesis pathway in congenital adrenal hyperplasia (CAH) HSD3B1 CYP11A1 HSD3B2 CYP17A1 CYP21A2 CYP11B2 PMC9110871__F3 Viral and cellular translation during SARS‐CoV‐2 infection TBK1 STAT1 STAT2 IRF7 IRF9 TRAF3 IRF3 IFNAR2 JAK1 IFNAR1 NXT1 TLR3 PMC7855940__F1 Multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease FEN1 IL1A HIF1A PNKP PCNA STAT3 PMC9209555__F3 Targeted Sequencing Identifies the Genetic Variants Associated with High-altitude Polycythemia in the Tibetan Population EPOR RELN EPO TCL1A PMC8953329__F1 An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications NHS CIT GLA PMC6759660__F2 Different ncRNAs regulate PDCD4 in mutiple ways CDK4 EZH2 MAP4K1 CDK6 PMC6896012__F1 The KEGG calcium signaling pathway PLN BCR DAO HRC MCU CAV2 TRDN PMC6524680__F6 PDGF effects in periosteum derived progenitor cells and its interaction with BMP2/Smad signaling PDGFRA SMAD1 DKFZp781O1323 PMC3578923__F8 Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components IVD OTC DLD PCCA DBT ASL ACADM PMC8742263__F2 Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation RUNX2 SOST SMAD1 DKFZp781O1323 PMC7982967__F2 Mechanistic actions of Ca2+ during myofibroblast differentiation TRPV4 TGFBR1 TGFBR2 TRPC6 TRPC3 COL1A1 TRPM7 PMC4742785__F4 Working model of an integrated axon degeneration signaling cascade NMNAT2 SARM1 ZNRF1 PMC5318464__F1 Diagram of immune responses induced by Leptospira sp NLRP3 CD14 IL16 TLR4 MYD88 PMC4510916__F2 Lf intervention upregulates the neurotrophin-signaling pathway in postnatal piglets MAPKAPK2 BAD NGF FRS2 GSK3B BDNF CRK PMC1817805__F2 AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer TSC2 MTOR PMC6821213__F8 FAE therapy modifies the metabolic-epigenetic interplay in multiple sclerosis to reduce pathogenic CCR6+ CD4 and CD8 T cells CCR6 PMC8699029__F1 System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach LEP POMC SOCS3 TRADD NPY AgRP TNF MTOR TRAF2 NR1C1 STAT3 PMC8877377__F1 High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral Cancer Patients SET STAT2 CXCL10 PMC2878924__F6 Two models for coupling the circadian clock to the cell cycle/checkpoint response WEE1 ATM ATRIP XPA ATR PMC3901112__F1 Autophagy is initiated by stimuli that activate the phosphatidylinositol 3-phosphate kinase, Vps34 ATG12 ATG3 ATF4 EIF2A DKFZp686F0183 PMC2878924__F5 DNA damage checkpoint pathways RAD1 RAD17 ATM TOPBP1 HUS1 ATRIP MDC1 RAD50 ATR MRE11A BRCA1 CDC45 PMC6039551__F3 MicroRNAs (miRNAs) regulate innate host immune response against influenza infection by targeting intracellular signaling pathways TBK1 TLR8 TLR7 TLR4 IRF7 TRAF3 TRAF6 IRF3 S100A9 TLR3 MAVS PMC8578384__F3 Candidate genes of SARS-CoV-2 gender susceptibility HMGB1 ENPEP CCL11 TLR9 BST2 IRF3 CCL4 GATA1 TLR7 TLR4 GC SERPING1 ADAM10 ACE2 TMPRSS2 PMC7392272__F2 Identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury AFP CSNK1D BTRC SMAD2 GSK3B MYC SNAI2 SMAD4 TEAD4 LATS1 MOB1A MOBKL1A LATS2 LIMD1 TEAD2 TEAD3 FRMD1 NF2 CCND1 DVL2 AXIN2 RASSF6 TP53BP2 SOX2 YAP1 APC AJUBA WWTR1 FBXW11 DVL3 PS1TP5BP1 DVL1 RASSF1 AXIN1 hCG_2014051 APC2 SMAD1 ACTG1 FRMD6 PMC9204329__F1 Of DEK proto-oncogene as a prognostic biomarker for colorectal cancer: An evidence-based review DEK BAX PMC5372848__F1 Activation of the RAS/ERK and phosphoinositide cell signaling pathways following the binding of cell survival signals to receptor tyrosine kinases (RTK) TSC2 TSC1 PTEN PMC8508836__F7 Survival Motor Neuron Gene Expression by Calcium Signaling CAMK4 TG SRSF9 PMC2805009__F1 Cross-talk between TCR and TGFB signaling networks FOS SMAD2 SMAD4 IL2RA JUN FOXP3 PMC3445581__F2 Transcriptional Differences between Rhesus Embryonic Stem Cells Generated from In Vitro and In Vivo Derived Embryos EDN1 SMAD2 FGF2 MYC MDM2 VEGFA SMAD4 STC1 CXCL12 SP1 CITED2 STAT3 PMC9442310__F7 miRNAs‐mediated control of MOV10 expression regulates L1 retrotransposition in mESCs DGCR8 DROSHA MOV10 PMC6283569__F6 E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling IGF1 IRS1 PMC2928541__F2 Wnt signaling pathway APC GSK3A PMC11016262__F2 Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis NOD1 NOD2 PMC11899224__F10 Effect of BBR on NLRP3 inflammasome pathway and TLR7/NFKB pathway NLRP3 TLR7 MYD88 IL1B GSDMD PMC11016262__F3 Immune cells along the gut-lung axis IL33 IL25 MADCAM1 PMC8151866__F1 BANK1 in B Cell Signaling and Disease TLR7 BCR IRF7 CYLD BANK1 AID LYN SRC TRAF6 MYD88 BLK PMC5101451__F1 Signaling pathways of TLRs TBK1 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR7 TLR4 TIRAP TAB3 PMC5506042__F6 Number of genes including those downstream of HIF-1 signaling pathway were up-regulated in the pancreas in response to HFD HEL-S-62p PTGIS ANGPTL4 CDKN1B IMPACT TGFBR2 WT1 SERPINE2 KDR CDKN1A TIMP4 NRP1 TIMP3 BTG1 BCL2 TIPARP BNIP3 TGFBR3 TGFBI PMC6988017__F3 PPI network analysis CYBA SMOC2 ARHGAP30 NCF4 WAS LPAR1 CD74 ECHDC2 RHOU PLOD2 HLA-DMA CXCL16 SLAMF8 opn PLCE1 SPTBN1 VWF CCL19 SERPINA1 RHOB OPA1 CD14 PLAUR MMP9 FOXO1 CTHRC1 THY1 TYROBP VCAM1 F5 IBSP KLF4 HLA-DMB ALDH2 PMC7300300__F3 Schematic illustration of the intervened network with Gegen Qinlian Decoction (GQD) based on ingenuity pathway analysis (IPA) ACACA NR1C1 GFPT1 ACOX1 THRSP HEL-S-162eP SLC2A4 ACADL PPARGC1A ACACB LPL PPARG ACADM PMC3004666__F1 Cetuximab in the treatment of colorectal cancer EGF BAD IGF1R PTEN MTOR PMC7332664__F1 Cores of the HIF pathway and the Hippo pathway VHL LATS1 LATS2 PMC8617980__F1 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? ADA PNP ADK PMC8617980__F2 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? PMC8617980__F3 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? NAT8L BTK ABCC6 PMC4159007__F8 Epigenetics and the Evolution of Darwin’s Finches CD14 STAC CTSK CD6 LBP CD40 IRAK4 FADD PARL TIRAP PMC5429547__F3 Differentiation of naïve Th cells into Th2 cells IL33 CD80 CTLA4 IL25 GATA3 PMC4159007__F9 Epigenetics and the Evolution of Darwin’s Finches DCT PMC10981339__F3 Anti-inflammatory effects of SIRT in IVDD TLR4 SUV39H1 SIRT6 RELA SIRT1 PMC4159007__F7 Epigenetics and the Evolution of Darwin’s Finches FST SKP1 ARHA TNF IFNG PMC10187169__F2 Pathways included in the model TSC2 NRP1 VHL SRC PTEN RHEB HES1 PMC4306671__F3 Pathway enrichment results: (A) hsa05200 (pathway in cancer); (B) hsa05218 (melanoma) KIT VIT BAD BRAF MDM2 CDK4 PTEN PMC11808223__F1 Intestinal changes in T2DM PYY MYD88 IL1B IFNG PMC5384647__F10 An ID2-dependent mechanism for VHL inactivation in cancer GIG8 VHL PMC8297547__F1 Protein Kinase R in Bacterial Infections: Friend or Foe? NLRP3 NLRC4 NLRP1 ATF4 ATF2 EIF2A IRF3 AIM2 IL1B FADD PMC8463317__F4 lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment CDK2 PTEN MYD88 EZH2 MTOR DNMT3B CDK6 PMC7835797__F1 Epigenetic Alterations in Renal Cell Cancer With TKIs Resistance: From Mechanisms to Clinical Applications QPCT HGF ZEB2 SMYD2 SOX5 PTEN EZH2 MTOR AXL PMC8422929__F1 Regulators of liver cancer stem cells TP53INP1 SOX2 HGF TBX3 AXIN1 KLF4 SETD2 STAT3 PMC8832957__F2 Tumorigenic bacteria in colorectal cancer: mechanisms and treatments RNF168 COX2 TLR4 MAX HEL-S-11 RAD51 PMC5332411__F3 IFN pathway of elephant shark SOCS2 SOCS3 IRF7 IRF8 IRF9 IRF3 IFNAR2 IRF6 PIAS2 SOCS4 PIAS1 IRF4 IRF2 PMC3747328__F1 The role of K+ channels during cell cycle progression and proliferation FOS ORAI3 MPZ TRPC1 IGF1 CDK2 UNK TRPV6 CDK4 CDC2 JUN ORAI1 TF PMC6144355__F1 Molecular mechanisms of TNBC APC EGFR MYC SMAD4 PTEN MTOR ETS2 AXL PMC6202827__F7 IL-1B signaling pathway in CXCR3-mediated MSC transendothelial migration CXCR3 MSC CXCL9 IL1B PMC4779832__F4 Cross talk between ROS and Keap1-Nrf2-ARE signaling pathway FYN HEL-S-64p NEDD8 PRX PMC4779832__F2 Cross talk between ROS and NFKB signaling pathway RELA RELB NEDD8 PMC4779832__F3 Cross talk between ROS and MAPKs signaling pathway STAT1 ATF2 GRB2 MEF2C MEF2D PMC5971010__F1 Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans NRARP ADAM10 PMC8999833__F3 Candidate Genes and Pathways in Rice Co-Responding to Drought and Salt Identified by gcHap Network ADM HAP1 PMC7404102__F1 SARS-CoV(-2) host cell infection, replication (Phase I) and induction of immune response (Phase II) APC IL6 ACE2 TMPRSS2 PMC6888566__F1 Wnt signal transduction ZNRF3 RNF43 LRP4 APC GSK3B LRP5 LRP6 ARHA GPR49 PMC7284145__F7 Biological pathway related to TMPRSS2 predicted by KEGG PLAT ERG ETV4 IL1R2 SPINT1 ETV5 TF TMPRSS2 PMC9368248__F6 Molecular Regulation of Yak Preadipocyte Differentiation and Proliferation by LncFAM200B and ceRNA Regulatory Network Analysis HES5 PML NUMB CDC20 HES1 PMC196255__F1A Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway IRS4 PTEN MTOR IRS1 PMC6888566__F4 Roles of non-canonical Wnt pathways in osteoclast differentiation and function DAAM2 WNT16 WNT4 NFATC1 PKN3 DCSTAMP ROR2 RHO SP1 JUN PMC5751354__F4A Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance HEL-S-26 HEL-S-133P PMC6032409__F3 Signaling pathway that results in the production of tumor necrosis factor alpha (TNFA) in macrophages after the stimulation by lead and lipopolysaccharide (LPS) CD14 TLR4 MYD88 PMC5786553__F1 Fatty acid synthesis in Mortierella alpina FADS1 DES TNLG7C GLA FADS6 PMC4942776__F6 Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification SUMO2 AMFR SAE1 CFTR PMC4916003__F1 Natural products as TLR agonists and antagonists affecting various stages in the signaling pathway, including downstream molecules MyD88 and IKK TLR4 TLR9 TRAF6 TLR1 PMC7278058__F6 Pathway modeling KIF7 CXCL10 APC INMT PNMT SUFU BIK RELA SHH BCL2 SMO NCF1 TRAF2 CALD1 PMC3939471__F1 Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle CLDN1 CD63 EGFR LDLR NPC1L1 TNF HRAS CD81 PMC7107758__F4 Resistance mechanisms to BRAF and MEK inhibitors in BRAF-V600E melanoma NF1 EGF HGF GRB2 NRG1 PTEN MTOR PMC7104317__F1 Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy IL18 TANK TRAF3 TRAF6 IRF3 IL6 TNF TLR3 TAB3 PMC6613635__F1 Simplified rationale for performing studies in NHP sepsis models of antibody inhibition of TNFA and IL-6 TLR4 PLG APC F3 IL6 TNF TF PMC4026009__F3 Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies PDX1 BAD NR5A2 BRAF INS NRAS GCK RB1 ONECUT1 NR2A2 HES1 SLC2A2 PKLR MDM2 CCND1 FOXA3 CDK4 NEUROD1 HNF1A TCF2 PAX4 IAPP MAFA FOXA2 NEUROG3 HNF4A CDKN1A PMC7999907__F1 Degradation of p53 induced by E6 variants of human papillomavirus (HPV) 16 favors metabolic reprogramming TIGAR HK2 INSR PMC3249681__F8 Simplified diagram depicting the proposed signaling pathway of the CB1 activation that inhibits the activity of small GTPase RhoA to inhibit motility of PC-3 cells ARHA RAC1 CDC42 PMC7999907__F3 Metabolic reprogramming is mediated by HPV 16 E6 variants through c-Myc, hypoxia-inducible factor (HIF)-1A, WNT, and miR-21 APC VHL HEL-S-133P PPARGC1B FASN STAT3 CD36 PMC7466715__F3 Signaling pathways of TGFB and Wnt involved in joint pathophysiology SMAD2 LRP5 SMAD1 DKFZp781O1323 PMC5943339__F3 Top networks of differentially expressed genes in PTvs.N as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders SPARC GCNT3 DGIC EHF POSTN SPRR3 MUC5B CEACAM1 MMP3 SULF1 CEACAM7 MUC7 RHCG PRSS2 GALNT12 BASH F3 TCN1 KRT13 STATH Nucb2 PMC5943339__F4 Top networks of differentially expressed genes in Mvs.PT as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders CD3D MAP2 IRF8 EVPL MYC RAB25 ERF CEBPA ADH1A ZMIZ1 CORO1A CPNE7 CDR2 TPP2 MAP2K1 TADA2B CDC42EP3 ZNF385B CTDSP1 ETHE1 KLF2 DSC3 GTSE1 HEL-S-117 PMC6059749__F11 miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer (NSCLC) through PD-L1 expression via the PTEN pathway CCR4 IFNGR2 PTEN IFNGR1 PMC7868342__F11 Signaling pathways involved in rhFGF20-mediated protection against BBB disruption both in vivo in TBI mice and an in vitro in a TNF-Alpha-induced HBMEC model GSK3B IL1B PMC3849582__F1 Network Diagram of the single C EP300 RPS3 AQP9 PMC8467361__F2 Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point ULK1 MTOR SIRT1 PMC6336830__F3 Summary of the mechanisms involved in the stimulation of brown adipogenesis, mitochondrial biogenesis and energy expenditure by some dietary molecules PRDM16 UCP1 ADRB3 NR1C1 TRPV1 TRPM8 PMC6184651__F7 ECM-receptor interaction pathway, (b) focal adhesion pathway, (c) regulation of actin cytoskeleton pathway, (d) TGFB signaling pathway TH HEL-S-28 PTEN BAG1 PMC8582887__F2 PI3KD Inhibitors as Immunomodulatory Agents for the Treatment of Lymphoma Patients BACH2 CCR7 PTEN RPS6 FOXO1 IFNG SELL FOXP3 PMC9156734__F3 Roles of different molecules related to the PI3K/AKT pathway in CECs in diseases and therapeutic strategies HMGA2 HMGB1 EGF IL16 IGF1R HGF TFEB IGF1 SRC SIRT1 BAX PMC9156734__F4 Localization and function of different molecules involved in the PI3K/AKT signalling pathway in the CE HGF IGF1 PMC7643595__F1 Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism CCK PYY NR1C1 PMC9156734__F2 PI3K/AKT signalling pathway in CECs EGF BAD IGF1R EIF5A MYC PTEN TRPV1 INSR TSC2 IGF1 SRC RPS6 PXN PCNA BAX PMC4931961__F3 TNFA Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB TBK1 TANK TRADD MADD FOS CD40 STRAP TNF EAF2 FADD PMC12080927__F6 Distribution of targets in the MAPK signaling pathway CD14 NLK EGF MAX FLNA GRB2 ECSIT TNF TRAF2 MEF2C PMC3692130__F1 Graphical representation of Wnt pathway as described in the KEGG repository () TBL1X CTBP1 MYC PORCN SENP2 DKK1 SOX17 CXXC4 NKD1 MMP7 SIAH1 CTNNBIP1 JUN FZD10 CER1 ARHA RBX1 WIF1 FBXW11 DVL1 PLCB1 NLK CACYBP NR1C2 ELL PMC6423135__F5 Pathway scheme with marked involved proteins BAD FRS2 AEN GRB2 SHE TRAF6 ARHA RAC1 JUN PMC3198763__F2 MTORC1 pathway controls cellular metabolism HSD17B12 PGM2 MVK ENO1 HMGCS1 HEL-S-87p HMGCR AGPAT5 HEL-S-162eP HEL-S-49 GDPD1 FADS2 ACLY HEL107 PFKP ACSL3 SLC25A1 HK2 GLS FASN PMC8958887__F7 M6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma METTL14 METTL3 IL6 WTAP IGF2BP2 SOX6 STAT3 PMC5125896__F1 Biosynthesis, remodeling and turnover of mitochondrial cardiolipin PGS1 PGP LPA AGPAT5 PMC8541410__F2 An Update on Innate Immune Responses during SARS-CoV-2 Infection TBK1 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRAK4 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 NLRP3 TLR7 TLR4 TYK2 JAK1 MAVS PMC11757636__F3 Influence of autophagy on the progression of pneumoconiosis TLR4 ZC3H4 MTOR PMC11757636__F4 Influences of apoptosis and pyroptosis on the progression of pneumoconiosis NLRP3 EIF2A GSDMD BAX PMC9571513__F7 Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway GPX4 KEAP1 PMC8748174__F1 Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases VCAM1 CDK2 BCL2 CDK4 PCNA BAX PMC8000702__F4 C-Peptide as a Therapy for Type 1 Diabetes Mellitus AGER GPX1 VWF IL1B PMC4933106__F1 Role of reactive oxygen species in age‐related neuromuscular deficits HSF1 PRX TF PMC2881367__F7 CircleMap display of the ErbB2 pathway ERBB2 ERBB3 NRG2 MTOR PMC4500525__F1 Mammalian inositol phosphate metabolism ITPK1 PTEN CSA2 PMC8136122__F7 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) PMC6562018__F2 Reduction in AAs (EAAs, BCAAs, and Met) induces uncharged tRNA and activates GCN2, eIF2A and ATF4/5, resulting in increased FGF21 production HEL-S-182mP IGF1 ATF4 PMC7533008__F4 Underlying glucometabolic mechanisms on pyruvate protection against diabetic nephropathy ATP8 PMC7076852__F7 Summary diagram of the proposed mechanisms underlying protective effects of C3G against glutamate-induced oxidative/ER stress apoptosis in HT22 cells ELL PMC2964046__F1 Currently-known relationships among genes analyzed based on manually curated examination of the published literature within the Ingenuity Pathway Analysis® Knowledge Base CSN3 MUC1 HEL-S-62p LALBA S100A10 F2R CSNK2A2 DGAT2 ACACA TGFBR1 MYC GPX1 EEF1A1 MTOR FSTL3 THRSP MMP2 SCD SREBF2 ACSL1 XDH CSN2 ABCG2 FASN PIGT LYZ ADFP HEL110 TNF IGFBP5 DGAT1 BTN1A1 INSIG1 HP CTSC FADS1 ACLY PPARG TGFB1 CD36 PMC5514720__F2 Transcriptomic analysis of HBCs reveals that the Notch pathway is differentially regulated during activation from dormancy NOTCH2 NOTCH4 NUMB DLL4 JAG2 NOTCH1 DLL3 NOTCH3 PMC7474159__F9 New concept based on this study PDGFRA PMC7027016__F4 Histone methylation plays a role in hypertension, aortic dissection, and pulmonary arterial hypertension EZH2 DKFZp686F0183 PMC8224166__F1 Microbial dysbiosis in carcinogenesis & cancer therapies IL13 IL6 PMC3399249__F2 Interactions between cytokine and glucocorticoid receptor (GR) signaling pathways STAT1 FOS TYK2 JAK1 STAT3 PMC9356167__F6 Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3B pathway GSK3B TG IL1B PMC9007519__F6 Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer MYB BAD CD37 MEI1 PTEN EIF4E MTOR IRS1 BRCA1 RHEB TSC2 BCR MDM2 RBL2 CD19 PMC4040986__F2 An Expanded Genomic Representation of the Phylum Cyanobacteria CS C6 ADK PMC4673013__F1 MicroRNA interactome in metabolic homeostasis TP53INP1 PMC7027016__F7 Histone methyltransferases and demethylases are involved in tumor angiogenesis SETD3 MMP2 FOXM1 SMYD3 VEGFA EZH2 HIF1A DOT1L GATA1 PMC5217345__F3 Fibroblast growth factor 21 (FGF21) regulates Sirt 1-mediated release of adiponectin from adipose tissue with relevance to NAFLD and the metabolic syndrome EBP PGC SIRT1 ADNP PMC7995212__F2 ACE2 in the second act of COVID‐19 syndrome: Peptide dysregulation and possible correction with oestrogen CSA2 ACE2 PMC9407429__F6 microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells BMPR2 ACVR1 RUNX2 NKX2-5 HOXC8 ACVR1B MAPK14 TGFBR2 TRAF6 GSC PMC8306954__F2 Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19 NLRP3 TRAF3 TNF ACE2 MLKL PMC5406035__F5 RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection RIPK1 RIPK3 IRF3 MAVS PMC9105267__F1 CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy SIRPA CD47 APC ACKR3 CXCR4 ZAP70 RAC1 CXCL12 PREX1 PMC8841526__F8 Identification of Key Genes Related With Aspartic Acid Metabolism and Corresponding Protein Expression in Human Colon Cancer With Postoperative Prognosis and the Underlying Molecular Pathways Prediction CYP2B6 LEFTY1 MAX ASNS CEBPA ID1 PMC6018060__F2 Macrophage Phenotype in Regulating the Response to Radiation Therapy IL13 GATA3 STAT3 PMC8645898__F2 SOX9: Advances in Gynecological Malignancies SOX9 HK2 PMC7186467__F1 Targeting mitochondria for the treatment of Parkinson’s disease (PD) PINK1 SDHB PMC10573925__F1 Effect of sclerostin on the Wnt/Beta-catenin pathway APC LRP5 LRP6 PMC6113920__F1 The human adrenal cortex: growth control and disorders AVPR1A GIPR MC2R ARMC5 PMC9574006__F2 Immune checkpoints in cardiovascular disease CD80 LAG3 FGL1 IFNG STAT3 PMC9495572__F1 Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease MAF KEAP1 BACH1 PMC3919531__F1 The Intertwined Roles of Transcription and Repair Proteins CETN2 FANCD2 TDG SLX4 EME1 XPC ATM BRCA2 RAD51 ERCC1 XPA ATR H2AX PCNA PMC7611290__F3 REV7: Jack of many trades PRCC POLD2 CLTA SHLD3 APC SHLD2 SIM2 HEL-S-2a CDC20 CDC2 EZH2 RAN TCF4 PMC3481134__F7 PRb/E2F signaling pathway mediates three distinct arms of TGFB tumor-suppressive effects CASP3 E2F4 SMAD4 PMC12028493__F12 Proposed mechanism underlying the anti-PD effect of epicoccin A PINK1 TSC1 ATG12 PPARGC1A HEL-S-64p PRKAA1 HEL-S-44 TUBA1B SESN2 MTOR PMC6100359__F1 Insulin signalling pathway activated in retina and RB TSC2 BAD GSK3B GRB2 INS UNK EIF4E MTOR RHEB INSR CBL PMC6932876__F1 Mechanisms of ADSCs differentiation into SMC and EC SMAD2 ARHA MED23 PMC2704234__F3 Immune activation induced by Beta-glucans CARD9 TLR4 TRAF6 SYK MYD88 PMC5400562__F8 Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway SMAD2 SMAD4 NQO1 PMC5790215__F1 Prediction of reaction knockouts to maximize succinate production by Actinobacillus succinogenes CIT MAL PMC7767220__F4 Roles of MMPs and TIMPs in the pathogenesis of human inflammatory diseases TIMP3 MTOR IL1B PMC9180633__F1 Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma RBPJ NRARP ADAM10 ADAM17 HES1 PMC5741248__F10 Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system CYP4F11 UGT1A3 ASAP1 AKR1B10 NAMPT GCLC AKR1C1 CD74 AKR1C2 NDUFA3 TBC1D2 DIO1 NMI HEL107 FMNL2 NMT2 GLUD1 TGFBI STAT3 APBB1IP PMC5831796__F1 Hedgehog signaling pathway BOC SUFU GLI3 GSK3B EVC SMO GAS1 PMC7190864__F4 Comparison of significant canonical pathways and upstream regulators in monocytes infected or non-infected with Mtb UT127 and UT205 isolates HMGB1 TH CD14 CS FEV PF4 PTGS2 OSCAR ENG RHO TNF TXN SELPLG RET TLR4 TREM1 EGR2 CD40 CD40LG PMC12068291__F2 Graphical representation of normal functioning of Notch signaling pathway and its importance in controlling cellular and developmental processes SUFU APC LRP5 LRP6 SMO TG CCND2 PMC7190864__F5 Death Receptor Signaling pathway is illustrating inhibition of apoptosis in monocytes infected with Mtb TRADD LMNA DIABLO TRAF2 HTRA2 FADD CYCS ARHGDIB PMC11356816__F9 Interactions between BAs and Other Viruses TLR4 STH PMC5831796__F4 GLI1-expressing hair follicle stem cells and their roles CD34 GPR49 PMC5794649__F2 FoxOs related signaling pathway in cancer progression and metastasis SIRT2 BAD CDK2 SMAD2 ZEB2 CXCR4 PTEN SGK1 PMC5110612__F1 Proteins with known or inferred roles in autophagy that underlie muscle pathologies in mice and humans ATG12 BAG3 LAMP2 BCL2 HSPB8 VCP LMNA DKFZp686F0183 VMA21 NBR1 MTM1 PMC7327642__F8 Mechanism underlying Notch ability to promote drug resistance in multiple myeloma (MM) microenvironment CXCR4 BCL2 ELL HES1 PMC3116873__F1 Oncogenic CagA Promotes Gastric Cancer Risk via Activating ERK Signaling Pathways: A Nested Case-Control Study GRB2 SRC CRK CRKL PMC3649461__F1 Signal transduction pathways of the amino acid (AA) response (AAR) ATF4 ATF2 EIF2A PMC9114642__F1 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury ATF4 EIF2A BCL2 TRAF2 BAX PMC9114642__F2 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury ATF4 EIF2A TRAF2 BAX PMC3540836__F1 Experimentally supported and inferred factors of Drosophila triacylglycerol synthesis and mobilization at lipid storage droplets PC PLIN1 ADFP TG PMC7585053__F3 Graphical representation of the five candidate pathways and their significantly contributing genes LARS2 CLTA CETN2 AP2A1 PLK1 NGF HEL2 AP2A2 BCAT2 GTF3C3 GSK3B PPP2R1A PCNT POLR2H EIF5 SSNA1 TBP AP2M1 HEL-S-76p PDHA1 DCTN1 YWHAG MAPRE1 TUBB POLR3B PLK4 NDE1 DNCL1 SH3GL2 AP2S1 BCAT1 GTF3C2 BDP1 TUBG1 IARS2 NEK2 CEP70 CLTC CEP63 PMC5356785__F1 ΔNp63A and microRNAs: leveraging the epithelial-mesenchymal transition SMAD2 GSK3B SMAD4 PTEN MTOR PMC9025012__F2 Implications of Sphingolipid Metabolites in Kidney Diseases SGPL1 DES CERK SMS KDSR PMC7049903__F5 Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia ACE2 PMC3093412__F1 Viperin Links Lipid Bodies To Immune Defense TLR7 TLR9 IRF7 IRAK1 TRAF6 IRAK4 MYD88 PMC9594894__F9 B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma CXCL10 CXCL9 MTOR B3GALT4 IRF-1 PMC3386270__F8 IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro CCR3 GRB2 SRC RHO RAC1 CDC42 PMC3116400__F1 DSBs in S and G2 phases of the cell cycle, collapsed replication forks, and daughter-strand gaps all require HR for their repair PALB2 BRCA2 RAD50 RAD51 MRE11A BRCA1 PMC3712126__F2 Bcl-2 family-regulated pathway and phenotypes in Bcl-2 knockout mice after status epilepticus BAD BMF BAX PMC7674659__F4 Mitochondrial carnitine shuttle, one-carbon folate metabolism and trans-sulfuration pathway MTHFD2L HEL-S-61p SLC25A32 SLC25A38 CPT1A SHMT1 SFXN1 CIC CPT2 MTHFD1 GLDC HEL-S-51e PMC4229513__F3 Outline of the targeted therapies, which are currently available or under development for the treatment of hepatocellular carcinoma, and the molecular targets on which they are believed to act upon BAD EGFR GSK3B MTOR PMC1952644__F1 Alternative signaling: cardiomyocyte B1-adrenergic receptors signal through EGFRs PLN EGFR SRC HBEGF PMC2751538__F7 Proposed VEGF-C/D cell signaling pathway to transduce LAM cell proliferation TSC2 VEGFC MTOR PMC4614397__F1 Feedback regulation of PI3K/Akt/mTORC1 signaling by Grb10 PTEN GRB10 MTOR PMC5976638__F3 The purinosome—a naturally occurring enzyme cluster? a Protein–protein interactions within the purinosome ADSL PAICS HEL-S-70p PMC6733417__F2 Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets KLF15 HGF SMAD2 BMP7 MTOR PMC506920__F6 Changes in transcripts associated with the DNA synthesis pathway CDC6 CDK2 CDC45 ORC2 PMC8319838__F3 Temozolomide resistance in glioblastoma - a comprehensive review EGF BAD EGFR PTEN MTOR PMC8319838__F4 Temozolomide resistance in glioblastoma - a comprehensive review NLK APC LRP5 TCF4 PMC8761945__F3 Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review ARHGEF1 ARHGEF7 KALRN DOCK4 ARHGEF10 RHO MCF2L CDC42 DOCK7 PMC8319838__F5 Temozolomide resistance in glioblastoma - a comprehensive review ULK1 ATM MTOR XBP1 STAT3 PMC4002322__F1 AMPK-p53-mTOR pathway in metabolic adaptation DRAM1 HEL-S-20 RHEB PMC11079312__F8 Proposed lipogenic pathway regulated by MUL1 during conditions of HFD NDUFS6 NDUFAB1 MUL1 FASN PMC4002322__F2 p53 regulation of energy metabolism TIGAR SCO2 GLS2 HK2 PMC7073173__F2 BMP signaling pathways BMP7 MTOR PMC5339410__F6 JAK-STAT and chemokine signaling pathwaysA SOCS3 SOS2 IRF9 MAPK3 IFNGR2 BCL2L1 IFNAR2 CCL2 STAT5B IL2RG LYN GRB2 SRC JAK3 JAK1 STAT3 PMC8508623__F1 Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane LYN SYK INSR PMC7874141__F1 Hypothetical model to illustrate activation of the complement system, inflammation and coagulation following SARS-CoV-2 infection HEL-S-62p PMC9569742__F1 Antiaging Activities of Phytochemicals in Dark-Colored Plant Foods: Involvement of the Autophagy- and Apoptosis-Associated Pathways TFEB ATG12 ATG3 ATG101 ATG14 DKFZp686F0183 PMC6726207__F1 Small molecules enhance knock-in efficiency RS1 ATM BRCA2 RAD52 RAD51 PMC6441195__F3 Exo-circRNAs play a crucial role via their sponging function and can be secreted into body fluid in tumors MACC1 CCNA2 PRDM16 EZH2 PMC7996181__F9 Mechanosensing by the nucleus SRC LMNA PMC7996181__F8 Hippo pathway and the role of YAP and TAZ in mechanotransduction of SC activity TEAD3 PATJ AMOT NF2 TEAD4 LATS1 RHO PTEN LPA LATS2 TEAD2 PMC3951857__F1 Wnt/Beta-catenin signaling pathway APC SOST LRP5 PMC2649571__F7 Beta-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in Motor Neurons APC POP1 PMC6589846__F1 Schematic illustration of the interleukin (IL)-12/IL-23 pathway STAT4 TYK2 IL6 IL23R IL12RB1 STAT3 PMC5484415__F7 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy MYC MTOR GLS PMC3185594__F8 Signaling pathways involved in JSRV Env-induced cell transformation TLR4 HYAL2 SRC RAC1 MTOR RHEB PMC8126205__F6 Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population IKBKB CD14 IKBKG TLR4 NR1i1 IFITM3 PMC2291100__F1 Proposed biosynthetic pathway of Tcm PKS and a comparison of hypothetical intermediates for two possible folding pathways F2 COCH PMC5294827__F4 Sexual dimorphism in the axonal signaling pathway PLXNB1 NGF NGFR ERBB2 ARHA RND1 ITGB1 CDC42 PMC4991391__F4 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications EGF EGFR MGAT5 PMC10619560__F4 Biosynthetic pathway of caproic acid and other organic acids in C. butyricum GD1-1 HBD PMC5484415__F3 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy PSAT1 ASNS GPT GLS PMC5484415__F4 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy OGT ATF4 EIF2A GLS PMC5484415__F5 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy ME1 GOT2 PMC4991391__F1 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications BRAF SMAD2 APC EGFR SMAD4 CCND1 BCL2 MTOR BAX PMC5484415__F6 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy SLC38A9 MTOR ARF1 GLS PMC5434854__F5 Top ranking gene network by gScore from the gene list uploaded from the SSRI versus control analysis TIAM1 FYN HGF GRB2 RAC1 SP1 HIF1A GRB7 CDC42 NCR2 PMC2801866__F3 Thrombospondin-1 (TSP1) binds to two receptors on endothelial cells that inhibit NO signaling CD47 FYN SRC CD36 PMC5434854__F6 Most significant canonical pathway from the gene list obtained from the esciptalpram versus control analysis ABCA3 ZDHHC3 ZNRF1 BRCA1 SOX9 ZNF652 RPS10 RXRB CHMP1A ATRIP PAQR9 MFAP1 DNASE1L2 CDC2 ATR H2AX RPS20 TTC14 MYT1 USP1 PMC2801866__F4 NO/cGMP pathway is a signaling node for pro- and anti-angiogenic signaling CD47 FYN SRC CD36 PMC2435382__F11 Hypothetical scheme illustrates the putative intracellular signaling cascades serving as the context for the data collected in the current study NONO GRB2 BDNF PMC7502477__F3 Chemical Structure and Biosynthesis of NAD+ NAPRT NAMPT HEL-S-90n PMC7212029__F6 Wnt negative regulation in ligand-dependent (LD) and ligand-independent (LI) tumours RNF43 APC NOTUM LRP5 LRP6 GPR49 NKD1 PMC4684266__F1 Simplified scheme of sulfur metabolism with an emphasis on the H2S-generating reactions PMC2801866__F1 VEGF binding to VEGFR2 on endothelial cells activates its Tyr kinase activity and results in autophosphorylation of the receptor at several cytoplasmic sites SRC SHB RAF1 PMC8117458__F7 Neuropathies and neurological dysfunction induced by coronaviruses ACE2 BDNF BAX PMC4489419__F1 Speculative model of FGF23 gene transcriptional regulation FGFR1 NR1i1 WNT3A PTH PMC3407651__F1 STAT3 signalling pathway in ALK+ ALCL SOCS3 MEI1 ALK IL2RA JAK3 HIF1A LAT ICOS STAT3 PMC10474093__F9 Working model CCR4 CCL17 CCL22 PMC9139536__F3 Novel T Follicular Helper-like T-Cell Lymphoma Therapies: From Preclinical Evaluation to Clinical Reality PLCG1 ITK APC LCK VAV1 GRB2 ARHA SYK CD80 STAP2 LAT ICOS PMC8733955__F2 Metabolism of invading and circulating (detached) cancer cells SPARC TWIST2 SOX2 SMAD2 GLS2 ACSS2 ACOT12 HEL-S-104 SOX4 VEGFC WNT3A PC CPT1A ASNS SRC FABP5 HEL-S-133P SCD5 CAMKK2 FABP1 FASN PMC8733955__F3 Metabolism of cancer cells colonizing in distant organs PC SIK2 PRODH SRC FABP5 HEL-S-51e HEL-S-104 PHGDH FASN CD36 PMC8035038__F8 Potential molecular mechanism of anticancer effects of SLT on ovarian cancer CCND1 CDK4 CDH2 BAX PMC8998816__F2 FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms YTHDF2 RARA ASB2 CXCR4 IL2 ERCC1 CEBPA SOX10 BNIP3 MZF1 HOXB13 PDCD1 PMC7603193__F1 Interactions between non-coding RNAs and the TGFB signaling pathway in hereditary hemorrhagic telangiectasia (HHT) DGCR8 SMAD2 TGFBR1 DROSHA SMAD4 SMAD1 DKFZp781O1323 PMC3407651__F2 MEK/ERK signalling pathway in ALK+ ALCL ALK JUNB RPS6 MTOR RHEB PMC3407651__F3 PI3K/Akt signalling pathway in ALK+ ALCL ALK SHH SMO PTEN RPS6 MTOR CCND2 PMC12243992__F2 Palmitoylation of EGFR, VEGFR, ER and GP130 RAB27A EGFR GRB2 IL11 ZDHHC13 ZDHHC3 PMC9520191__F10 Polysaccharide from Atractylodes macrocephala Koidz binding with zinc oxide nanoparticles: Characterization, immunological effect and mechanism TLR4 CD80 MYD88 IL1B TIRAP PMC5148674__F3 The p53 tumor suppressor in metabolism and diabetes PGC GLS2 RRAD ARHA HEL-S-20 PMC2844217__F1 Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P ME1 ME2 ME3 PMC5378285__F8 A hypothetical mechanism for the anti‐tumor effects of verteporfin in pancreatic ductal adenocarcinoma (PDAC) cells MMP2 CCND1 CCNE1 BAX PMC3772385__F8 Model describing the relationship of osteoblast-produced Bmp2 and connections to VegfA production and increased microvascularization that serves as a major niche for mesenchymal stem cells BMP2 MSC VEGFA COL1A1 PMC5155150__F6 Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells LEFTY1 CER1 SFRP1 DKK1 BMP4 PMC11818554__F7 Pathway regulating MSC osteogenic differentiation RUNX2 ATF4 SMAD2 SMO PTH PMC11818554__F2 Wnt Signaling in MSC osteogenesis WNT3 PC APC SOST WNT1 MSC LRP5 RHO JUN ZBP1 PMC6905465__F2 DNA damage response pathway ATM RAD51 ATR FANCE BAX PMC4007761__F2 Secretory pathway components studied in zebrafish and implicated in human diseases SEC24C SEC31A TRAPPC11 ZNF547 TRAPPC9 DKFZp434B2017 PMC2905230__F1 Simplified Overview of TLR Signaling CD14 TLR4 IRF7 IRAK1 IRF3 IRAK4 PMC8141582__F7 Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor TSC2 TSC1 FDPS MTOR CYP17A1 HMGCR PMC4887533__F1 Overview of the ferroptosis pathway HEL-S-64p GLS2 TFRC PMC7037253__F1 IL-10 production is metabolically regulated IL10 TLR4 AHR CD46 PBX1 MTOR SIRT1 STAT3 PMC7037253__F2 Anti-inflammatory response initiated downstream of the IL-10R ETV3 HGF SOCS3 LIF GSK3B IL24 HMOX1 DDIT4 STAT1 ZFP36 NFIL3 TYK2 IL10RA OSM SBNO2 STAT3 PMC2756670__F3 Potential mechanisms of estrogen-mediated signaling through estrogen receptor (ESR) and G protein-coupled receptor 30 (GPR30) EGFR SRC HBEGF PMC2756670__F4 The proposed model underlying the potential lithogenic mechanisms of estrogen through the estrogen receptor 1 (ESR1) pathway in the liver ABCB4 ABCG8 ABCG5 ABCB11 PMC4307189__F2 Network view of (A) 104, (B) 188, and (C) 299 putative drug-resistant cross-talks between pathways using Reactome, KEGG, and WikiPathway pathway databases in Breast Cancer Cell-line: SKBR3 (GSE38376) KIT ERBB4 NGF EGFR MYC SMO GNAS RHO PMC3035754__F1 Regulatory network governing mitochondrial functions orchestrated by PGC-1A VHL NR1C1 SIRT1 PMC9495868__F4 Suppressing the PI3K/AKT Pathway by miR-30d-5p Mimic Sensitizes Ovarian Cancer Cells to Cell Death Induced by High-Dose Estrogen MAPK8 SMAD2 MYC BMI1 RANBP2 CDK6 SAP18 SIAH1 MDM2 NOTCH1 IQCB1 EZH2 IRF2 MAP3K1 MAP3K7 ENO1 PRPF40A RNF2 UBE2D2 UBE2E1 NEDD4 CALM1 YWHAQ PPP1CC HEL25 WDR5 KPNA2 YY1 CLTC HEL113 RPLP1 PCNA TBK1 SUMO3 MYH9 CUL5 DYNC1H1 DCUN1D1 IGF1R HIPK2 BTRC UBE2D3 EEF1A1 DHX15 ITGA4 FZR1 ISG15 SEC24C PABPC1 ATM BIRC3 APP CCND1 EIF4A3 CDC2 DDX5 YWHAG PRKDC JUN RPS15A RPLP0 UBE2D1 RUNX1 CBX3 SKIL VHL DDX3X PARP1 RAC1 PRPF19 BCL6 CASP3 BIRC2 IXL SMC3 SRSF7 REL HEL-S-93 SMAD1 SP3 PMC4503552__F1 Endocannabinoid system giving rise to endocannabinoids (2AG and AEA) and arachidonic acid and subsequently synthesis of prostaglandin glycerol esters, prostanoids, and prostamides MGLL PTGS2 FAAH PTGS1 PMC12014746__F4 Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats TLR4 VEGFA VEGFB PMC9599575__F3 Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs EGF IGF1 INS IL1B SIRT1 PMC12131810__F5 Signaling pathways for axonal regeneration within neurons PINK1 SOCS3 GAP43 SNPH MTOR STAT3 CAMKK2 PMC3882535__F3 Novel GPCR-based signaling mechanisms in ASM RGS4 PLCB1 PMC8478603__F1 Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells CD40 CD80 PMC4478640__F8 Model for negative feedback loop by which the ARGOS family desensitizes ethylene signaling OSR2 OSR1 PMC7407804__F1 Signaling events downstream of EphA activation by ephrin-As ARHG VAV3 ARHA RAC1 VAV2 PMC3408193__F9 Proposed protective pathway by E-LP against glutamate-induced apoptosis in RGCs PLCG1 A2M GSK3B PMC5404978__F10 Proposed model for FoxO1 and AMPK regulation of EtOH-induced autophagy ULK1 SQSTM1 AMBRA1 ATG14 PMC9027827__F3 Advances in the development of new biomarkers for Alzheimer’s disease CASP3 CASP12 GSK3B CDK5 LPL CASP9 PIGS TNF MTOR CASP8 FADD PMC8788185__F3 Molecular mechanism of therapeutic approaches for human gastric cancer stem cells SMO STAT3 PMC9675776__F9 GediNET for discovering gene associations across diseases using knowledge based machine learning approach EGF CHUK ACACA ALB VEGFA MYC UMPS PTEN NRP2 RICTOR ATM XDH BAX PMC316360__F6 Interphase/S phase omission between the two meiotic divisions MOS WEE1 MYT1 PMC5663306__F1 Bile acid metabolism and signaling in liver disease and therapy CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC6563994__F6 Social status regulates the hepatic miRNAome in rainbow trout: Implications for posttranscriptional regulation of metabolic pathways HEL-S-30 KCNA4 PCK1 ENO1 PFKM HEL-S-68p MYH6 HEL-S-162eP HEL-S-49 PC TAC4 CPEB4 ATF4 PIGC PDHA1 MPC1 ENO2 RRP8 PFKP PMC9180999__F4 PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity CGAS PQBP1 IRF3 IL6 TNF PMC5434854__F1 Top ranking gene network by P‐value from the gene list uploaded from the NRI versus Control analysis TAF1 ID4 DEDD ATF1 CREB1 RPS3 CDK8 CREB3 PMC5434854__F2 Top ranking gene network by gScore from the gene list uploaded from the NRI versus control analysis TRAK1 NPY1R TRAF6 IRAK4 MYD88 MAP3K7IP1 UBC NTSR1 TLR4 TRAK2 GALR2 NPFF NTSR2 MAL PMC5434854__F3 Association between the gene list and known processes pathways reveals a role for Glucocorticoids NFKBIA GRIP1 FKBP4 SUMO1 PMC5434854__F4 Top ranking gene network by P‐value from the gene list uploaded from SSRI versus control group analysis NAB1 RPL13a VAT1 POM121 APC CREB1 TPR RPL13 RPL18 NUP210 COG1 PRICKLE4 RPL11 CDC20 NUP58 CPOX PAQR9 TJAP1 PMC4073101__F3 Cilia and cilia-associated proteins in cancer HGF EGFR VHL MTOR AURKA MMP2 NEDD9 SRC CCND1 ROR2 TGFA HEL-S-133P STAT3 PMC6944116__F5 Protein interaction and functional clustering of identified hits and known UV‐G2 checkpoint components PPP2R1A CDKN2A WRN FEN1 SMARCA4 ENSA ARPP19 GDF15 LZTS1 PHLDA3 RAD51 CDK4 BTG2 PPP2R2A JUN MASTL NONO RPA1 XPC PARP1 SCRIB DDB2 LMNA UBE2E2 DDB1 RAD18 FBXO32 PPP2CA VCP ATR PCNA SKP2 STAT3 PMC4802403__F1 The mTOR pathway, it's classical upstream inputs and downstream targets.mTOR exists as two separate signalling complexes which are structurally distinct TSC2 RICTOR TSC1 EGFR TBC1D7 GRB2 GRB10 MTOR DEPTOR IRS1 PMC8617565__F4 Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity BAD NGF FRS2 GSK3B GRB2 MAPK14 BDNF CRK SHC3 PMC7961974__F8 Pathway activation patterns of the NOTCH pathway in the different CD-groups NUMB CREBBP APELA LFNG PMC11466965__F6 Signaling pathway of HO-1 in the protection of diabetic nephropathy NLRP3 GPX4 FACL4 TNF PMC4876232__F1 FGF21 induces preventive effect on CVDs through multiple signaling pathways FGF21 BAD NR1C1 SIRT1 PMC11466965__F4 HO-1 may be involved in diabetic cardiomyopathy by regulating various signaling pathways NLRP3 GPX4 SMAD2 BAX PMC6410037__F2 Telomere length maintenance mechanisms CTC1 STN1 TEN1 RAD52 RAD51 POLD3 PCNA TERT PMC7842273__F1 Two major arginine metabolic pathways: NO synthesis vs ARG2 OTC AMD1 ARG1 ASL PMC6364748__F2 Oncogenic and tumor suppressive signaling involving Dmp1 and Arf TBX2 TBX3 MYC BMI1 PTEN TNF ATM TWIST1 MDM2 CCND1 YY1 CDK4 EZH2 JUN PMC2753833__F4 Transition to endocycles in Drosophila CDC6 APC CDC2 PMC9363567__F3 Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases CD14 CD47 PMC4698487__F2 Perspective on targeting copper metabolism for the treatment of hepatocellular carcinoma ATP7B COX17 ATOX1 HEL-S-44 CCS PMC3702256__F1 Pathview: an R/Bioconductor package for pathway-based data integration and visualization MCM2 ATM TTK SMC3 CDC45 SKP2 PMC4320984__F8 Activation of Beta-catenin Signaling by TFF1 Loss Promotes Cell Proliferation and Gastric Tumorigenesis TFF1 GSK3B CCND1 PMC1369209__F3 Models for ECT-2 activation and its role in activating the EGFR/RAS/MAPK pathway EGF ECT2 EGFR GRB2 PMC5392598__F4 Schematic overview of the sex development gene regulation network RSPO1 NR5A1 WNT4 LHX9 FOXL2 SOX9 FGF9 SRY PMC11906670__F2 Biosynthesis pathways and receptors of AA-derived eicosanoids and their influence on cDC migration LTA COX1 KPG_011 CCR7 PMC11906670__F3 S1P synthesis and influence on cDC migration S1PR2 CCL21 CCR7 S1PR1 S1PR3 CCL19 S1PR5 SPHK1 S1PR4 SPHK2 PMC10136533__F2 Regulatory network of OTUD5 in immune response and DNA damage repair TBK1 RORC CGAS IRF7 UBR5 TRAF3 IRF3 MYD88 SSRP1 PDCD5 BAX PMC8804138__F3 Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?—a review HMGB1 LPA PMC10136533__F3 OTUD5 is involved in the development of cancer (see also Table 1) PML CCR2 RNF186 PTEN MTOR DEPTOR TRIM25 OTUD5 PDCD5 PMC9208207__F5 Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis TBK1 IKBKE TRADD CSF3 GSK3B TRAF3 TRAF6 CCL7 CCL2 USP25 IL17RB IL17RC CEBPB IFNG MMP3 ELAVL1 IL18 CCL17 IL17RA MAPK1 IL4 CSF2 CASP8 IL1B CCL11 IL13 FOS PTGS2 MMP9 LCN2 IL6 TNF NFKBIA TRAF5 RELA CCL20 TRAF2 FADD TRAF4 TAB3 PMC4624682__F5 Proposed model illustrating the multiple signaling pathways by which PGRN (Atsttrin as well) exerts its anti-inflammatory actions TRADD TRAF2 FOXP3 PMC11906670__F4 Biosynthesis and role of 7A,25-OHC in cDC localization within secondary lymphoid organs CXCL13 CH25H CCL21 CCR7 CXCR5 CCL19 CYP7B1 PMC11788143__F2 Signalling pathways in pancreatic and peripancreatic cells whose abnormalities cause diabetes of the young at maturity (MODY) PDX1 ADIPOR1 INS GCK MTOR BLK TCF2 PAX4 RHEB TSC2 RFX6 TSC1 HNF4A ABCC8 PMC7326080__F2 TNF induced cell death signaling HMGB1 TRADD TNF TRAF2 FADD MLKL PMC7326080__F1 TNF induced canonical NFKB pathway TRADD CYLD RELA SHARPIN OTULIN TRAF2 TAB3 PMC8508208__F1 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma ME1 GOT2 PMC8794746__F1 New Insights into LINC00346 and its Role in Disease WDR18 CCNB1 MYC CDC2 STAT3 MAL PMC6354878__F4 Signaling pathway and GO analyses were performed to identify the biological functions of the subsets of differentially expressed genes after BP5 treatment APC HEL-S-69p PMC8794746__F2 New Insights into LINC00346 and its Role in Disease ZNF655 ANKHD1 SZRD1 PMC6089846__F3 Rubone and the p53 pathway LEF1 MDM2 CD44 BAX PMC8508208__F4 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma ISG15 NODAL SHH MTOR OSM TGFB1 PMC8490884__F10 Neurodevelopmental Disorders in Patients With Complex Phenotypes and Potential Complex Genetic Basis Involving Non-Coding Genes, and Double CNVs GLRA3 SHOX NIPA2 ABHD4 GNAZ ADCY5 INPP5A BUD13 CYFIP1 NIPA1 RBFOX1 LRRC40 PMC4740183__F3 Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease BHMT2 HEL-S-61p ALDH7A1 CHDH OTC ARG1 ASL PMC5844108__F10 Different metabolic responses in acquiring FK866 resistance in CEM RES (a) and MDA RES (b) cells NAPRT NAMPT HEL-S-90n HEL-S-133P PMC6089846__F5 Relationship between AR translocation and the AKT signaling pathway TSC2 TSC1 FKBP5 PTEN MTOR JUN RHEB PMC3565434__F8 Schematic diagram of proposed CD44-regulated signaling pathway FYN LCK CD44 PMC7322178__F5 Metabolic impact of tyrosine kinase inhibitor (TKI) administration RET EGFR MTOR PMC4611193__F2 The regulation of intestinal iron transport HP HFE TF PMC5540723__F3 VEGF/VEGFR signaling and the approved therapeutic agents targeting this signaling VEGFC VEGFA VEGFB PMC4882508__F1 Pathway Compartmentalization in Peroxisome of Saccharomyces cerevisiae to Produce Versatile Medium Chain Fatty Alcohols PEX7 PEX19 PEX5 PMC5540723__F1 PD-1 pathway signaling and the targeting of the PD-1 pathway during cancer immunotherapy APC CD80 PMC4531352__F3 Maize Primary Metabolic Network Involving Key Genes and Metabolites Identified in This Study.Metabolites that were not identified in this study are shown in purple TH CS PDK2 DST IVD PMC7492291__F1 Apoptotic signaling pathways triggered in CD4+CD8+ double positive (DP) thymocytes during T GC PRLR TNF PRL PMC6894428__F3 Simplified model of the molecular evolution of each colorectal cancer subtype BRAF CDX2 APC PMC5287404__F4 Roles of malyl-CoA/Beta-methylmalyl-CoA lyases and malyl-CoA lyase/thioesterases (red) in different acetate assimilation pathways: the methylaspartate cycle in H ME1 ME2 PMC4023931__F3 Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma SPARC ERMAP THRAP3 FOS SACS MYC BCL2L1 GPR34 PTEN RB1 CDKN2A CLEC11A HEL-S-31 SPTA1 LATS2 SRSF9 COL4A6 BCR HEL-S-306 HMGN1 PSG5 ARHGAP22 WWOX PMC8375225__F7 Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer CDK4 COIL STAT3 PMC4833098__F3 Canonical PPAR signaling pathway UBC PLTP UCP1 AQP7 HEL-S-28 LPL CPT2 ACD PMC4083752__F1 Unexpected targets and triggers of autoimmunity FOXO3A IL23R SGK1 FOXO1 PMC8838632__F2 Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest ULK1 APAF1 CDK2 BCL2 CDK4 CDC2 MTOR CDK6 BAX PMC3019561__F2 Mitochondria and the synthesis of phospholipids CDS1 PC PGP PMC5489807__F3 Levels of crosstalk between the HIF and the NFKB pathways RELA KDM2A PMC7609840__F1 Relevant JAK-STAT signaling pathways in the pathogenesis of Spondyloarthritis STAT1 STAT4 TYK2 JAK3 JAK1 IL23R IL12RB1 STAT3 PMC5489807__F1 Activation pathways for canonical and non-canonical NFKB signalling RELA LTB RELB TNF MAP3K7IP1 TRAF2 FADD LTBR TAB3 PMC11598946__F3 Cytosolic sensing of BRSV by RIG-I, MDA-5, and NOD2 TRAF6 IRF3 NOD2 MAVS PMC11598946__F5 Some of the respiratory syncytial virus’s immune-evading mechanisms TLR4 IRF3 MYD88 NOD2 TLR3 MAVS PMC9354928__F2 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma TSC2 TSC1 PTEN MTOR RHEB PMC8704013__F1 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression CCL2 IL4 ASL PMC9354928__F3 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma ULK1 ULK2 EIF4E HIF1A RHEB MLST8 PMC8704013__F2 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression EGF CCR2 ARG2 CCL2 IL4 TNF MTOR PMC8616477__F2 Melanoma Targeted Therapies beyond BRAF-Mutant Melanoma: Potential Druggable Mutations and Novel Treatment Approaches BAD BRAF MDM2 BCL2 CDK4 EZH2 MTOR ARAF TET2 BAX PMC10820115__F3 Canonic polyamine biosynthetic pathway of mammals (hosts of trypanosomatids) EIF5A PMC7606114__F4 Lysosome and pyroptosis NLRP3 IL16 GSDMD PMC6851521__F2 The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism ATG3 PTEN MTOR PMC4941807__F5 Schematic illustration of the coagulation pathway and its inhibitor systems HGF PROS1 A2M TFPI THBD PROC ANXA3 ANXA4 PMC7887310__F1 IFN action on cellular metabolism pathways IDO1 CH25H PMC4941807__F4 Ingenuity pathway analysis revealed hepatocyte growth factor (HGF) as an upstream regulator HGF A2M THBD ANXA3 TGFBR2 TNF HIF1A HRAS STAT3 PMC6379038__F2 Cholinergic signaling via nAChRs and muscarinic acetylcholine receptors (mAChRs) regulates striatal function TH STAT3 PMC5016220__F1 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets APOM S1PR2 ORMDL3 S1PR1 S1PR3 S1PR5 S1PR4 SPN CERK SPNS2 SMS PMC5016220__F2 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets S1PR2 S1PR1 S1PR3 RHO S1PR4 PMC6851521__F1 Molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism PTEN MTOR STAT3 PMC5584221__F9 EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway SRC PMC7770114__F7 Chronic administration of l-DOPA leads to a sensitization of D1 receptors, which maintain the over-activation of PKA in LIDs GPR6 FOSB FAAH TRPV1 PMC4315049__F2 Secretion of FABP4 in association with lipolysis PDE3B AQP7 GC HEL-S-104 IRS1 PMC8750774__F2 Metabolic Implications of Immune Checkpoint Proteins in Cancer FES CD80 ICOS PMC8957101__F1 Hidden One: What We Know About Bitter Taste Receptor 39 PLCB2 CALHM3 CALHM1 TRPM5 PMC3887879__F3 Nutrient signaling to mTORC1 SLC7A5 RUVBL2 RUVBL1 SH3BP4 SLC3A2 MTOR RHEB MLST8 GLS PMC3887879__F1 MTOR signaling pathway TSC2 TSC1 TBC1D7 DEPTOR RHEB PMC4555691__F1 Schematic representation of sarcosine pathway HEL-S-182mP PIPOX PMC8979868__F2 Novel insights on GM1 and Parkinson's disease: A critical review ST8SIA5 UGCG B4GALT5 GAL ST8SIA1 B3GALT4 ST3GAL5 PMC3498346__F1 Impaired Skeletal Muscle Regeneration in the Absence of Fibrosis during Hibernation in 13-Lined Ground Squirrels MYF5 PAX7 MYF6 PMC5701683__F2 Signal transduction in melanoma with regard to the role of the SOX10-MITF pathway BRAF NRAS MIA CCND1 TYRO3 MTOR PMC4318882__F7 The murine parturition pathway STAT5B GAA PMC8192743__F12 Mechanistic insights into TNFR1/MADD death domains in Alzheimer’s disease through conformational molecular dynamic analysis TLR4 TRADD TRAF6 MYD88 TNF PMC8038160__F4 Flavonoids modulate growth pathways in cancer TSC2 EEF2K EGF VIT EEF2 EGFR GRB2 PTEN MTOR DEPTOR RHEB PMC8038160__F2 Flavonoids modulate inflammation and immunity pathways in cancer NLRP3 VIT TLR4 TRADD MMP2 TRAF5 MMP9 SRC TRAF6 TRAF2 STAT3 PMC3649201__F1 Current view on the complex interplay of pathogenic factors in cholesterol gallstone formation ABCG8 ABCG5 HEL-S-70p PMC7838196__F8 PI3K-AKT signaling pathway MYB BAD BCR SYK PTEN RAC1 RAF1 MTOR CD19 PMC8468898__F4 Validation and Selection of New Reference Genes for RT-qPCR Analysis in Pediatric Glioma of Different Grades CS SCD HEL-S-30 ACACA FH ACLY HEL107 FASN HEL-S-162eP PMC4710243__F1 Beta-Catenin participates in cadherin-mediated cell adhesion and is a transcriptional coactivator in the canonical Wnt signaling pathway APC GSK3B PMC4308835__F1 Nuclear factorK B activation pathways CD14 TLR4 RELB CD40 PMC3703119__F5 Schematic representation of the pathogenetic mechanism of AD copper phenotype ATP7B ATOX1 COMMD1 PMC4046186__F1 Intrinsic and extrinsic apoptosis signaling pathways (adapted from ref CASP3 CASP6 TRADD APAF1 CASP9 CASP2 CASP8 FADD CYCS PMC4947825__F1 Cascades of the coagulation system PC TFPI PLG VWF TF PMC4947825__F2 Interactions between coagulation and inflammation during IAV infection TFPI VCAM1 VWF PMC4965186__F5 a) Systems modeling framework used in this study MLNR RPE PMC11032739__F7 Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair ATR H2AX RBM17 PMC7226820__F3 Main signaling pathways involving LSEC during liver regeneration HGF WNT9B NOTCH1 PMC4629055__F2 Divergent macrophage activation pathway CCL17 CCL2 CCL18 CCL22 PMC9234708__F3 Biomineralization associated alkaline phosphatase as a potential marker of bone metastasis in the patients with invasive breast cancer LVRN APOA4 ENPEP RUNX3 HHIPL2 RUNX1 MRAP2 RUNX2 FOLR3 MRAP BMP2 CD34 GPLD1 ALPL ERAP1 PPARG ALPG COL10A1 ALPI PMC8038136__F1 CK1A and CK2 regulate many cellular processes that sustain the tumor phenotype CARD11 BCL10 ATF4 APC GSK3B MDM2 CDC37 PTEN MTOR PMC3960188__F1 mTOR pathway in colorectal cancer: an update TSC2 TSC1 PTEN IRS1 RHEB PMC4669955__F2 Emerging Role of ABL Kinases in Solid Tumors ABL2 RBPJ CXCR4 CCND1 SRC RHO DAB1 MTOR TRIO PMC3960188__F2 mTOR pathway in colorectal cancer: an update RICTOR GRB10 MTOR SGK1 PMC2688755__F2 Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen FEN1 POLE FANCD2 TDG ATM BRCA2 RPS3 ATR H2AX PCNA PMC3721286__F3 Simplified scheme presenting multiple feedback loops in the EGFR pathway EGR1 ZFP36 MAFF LRIG1 FOS EGFR MYC GRB2 JUN PMC7864484__F2 Nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family apoptosis inhibitory protein (NAIP)-NLR family caspase recruitment domain-containing protein 4 (NLRC4) inflammasome-mediated PANoptosis, inflammatory cell death CASP3 NLRC4 IRF8 CASP8 MLKL GSDMD PMC3730684__F1 The Smad-dependent TGFB signalling pathway upon stimulation with TGFB and BMP VIT SI SMAD2 SMAD4 SMAD1 PMC9260904__F10 Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension CEBPD EDN1 EGFR TNF ADM PMC7524949__F2 Synthesis, release, and metabolism of intra- and extra-cellular purines ADA PNP PMC2725405__F6 Regulation of IFN response genes by TLR3 signaling ATF2 IRF3 TLR3 PMC3832239__F2 Mitochondrial Retrograde Signaling at the crossroads of tumor bioenergetics, genetics and epigenetics IGF1R EBP RYR1 PMC8946699__F1 New Directions and Challenges in Targeted Therapies of Advanced Bladder Cancer: The Role of FGFR Inhibitors PTEN MTOR PMC4134018__F3 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii BCL2A1 BCL2 PMC4383015__F5 Foxp3-biding genes in ‘pathway in cancer’ C14orf166 VHL SMO PMC7048211__F4 Proposed direct role of HTRA1 in bone formation BMP2 SMAD2 IBSP BMP5 SMAD4 MTOR SMAD1 DKFZp781O1323 BMP4 PMC3919163__F2 LPS receptor signaling pathways TBK1 TLR4 IRAK1 TRAF3 TRAF6 IRF3 MYD88 MAP3K7IP1 TAB3 MAL PMC3271653__F1 Testosterone signaling pathways EGFR SRC PMC8538586__F3 Forms and Methods for Interferon’s Encapsulation STAT1 STAT2 IRF3 IFNAR2 IFNAR1 MAVS IL10RB MX1 IFIT1 PMC6174781__F4 Colon Epithelial MicroRNA Network in Fatty Liver MMP3 ELAVL1 MMP14 PRKCZ EPO MMP2 PROC PPP2CA HEL-S-107 RPS15 EIF4G1 PMC10744281__F1 Interconnection of glycolysis with other metabolic pathways ME1 EGF PFKFB4 MTOR CIT HEL-S-32 HMGCR RHEB MDH2 TSC2 HEL-S-26 TSC1 FH HK2 FASN PMC10744281__F3 Apoptotic process by glycolysis and lipid metabolism in glioma BCL2 FADD HK2 FASN BAX PMC10744281__F4 Autophagy by glycolysis, lipid metabolism, and glutamine in glioma EGF ULK1 AKT1S1 ULK2 ATG10 HIF1A MTOR HMGCR RHEB HEL-S-68p TSC2 TSC1 TFEB BCL2 SPHK1 BNIP3 HEL-S-133P SIRT1 HK2 GLS FASN PMC5549471__F2 HN inhibits OS and ER stress in RPE by direct and indirect mechanisms ATF4 EIF2A STAT3 PMC6290495__F4 Regulatory model for the flow pathway of central carbon metabolism and a proposed scheme for lipid biosynthesis in T CS OGDH LPA MCAT HEL-S-162eP PMC5818417__F2 Anti-fibrotic effect of selected polyphenols SMAD2 SMAD4 NOX4 PMC4691085__F2 Crucial role of miRNAs in coordinating vast prostate cancer (PC) metabolic processes HEL107 HMGCR FASN GLS PMC3841791__F9 Predicted upstream regulators inhibited in DA rats but activated in congenics EGR1 RUNX2 FOSL1 AGTR1 FGF2 MYC CREB1 CEBPA RB1 FOXO1 CEBPB NFKBIA LIPE CDKN1A RELA SP1 NR1H3 PPARG JUN PMC4563160__F8 FASN inhibition blocks metabolic and signal transduction pathways vital to cancer cell growth, proliferation, and survival MYC LRP6 RPS6 MTOR FASN PMC3789231__F7 Mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3) BTRC EGFR GSK3B ELP2 STAT3 PMC6346071__F1 Cysteine anabolism and catabolism pathways GOT2 HEL-S-64p pcap PMC4086482__F1 Phosphoinositide-3-kinase-Akt-mTOR pathway TSC2 TSC1 PTEN EIF4E MTOR RHEB PMC8394255__F2 Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina GC STAT3 PMC4134018__F1 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii EEA1 RAB1B RHO HEL-S-130P PMC5635482__F1 DNA interstrand crosslink (ICL) repair: Crosstalk between the Fanconi Anemia (FA) pathway, translesion synthesis (TLS) and homologous recombination (HR) FANCD2 MCM7 CDC45 MCM3 MCM5 MCM6 MCM2 FANCM RAD51 FANCA ATR FANCB PCNA USP1 PMC6927724__F8 MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice IMPACT PTEN MTOR PMC7227813__F2 Anti-lipolysis regulation by insulin on the morphological differences of adipose tissue PDE3B IRS1 PMC8022592__F5 Differential regulation of breast cancer cell growth by methyljasmonate (MeJA) or MeJA‐treated leaf disks CDC6 CDK2 CCND1 CCND3 CCNE1 PMC11079205__F3 GLP-1 effects on bone RUNX2 GAB2 PMC11079205__F4 Incretin hormones’ effect on bone IGF1 RUNX2 GIPR PYY PTH GIP PMC3704444__F1 Interaction between quality control systems for ER protein folding and RNA biogenesis ELF2 EXOSC3 EIF2A UPF2 SMG1 SMG6 DIS3 SGA56M PMC11012798__F2 C and N metabolisms affected by N sources FRK HEL-S-162eP PMC11079205__F1 Bone remodeling is a dynamic process that is completed with the participation of BMU IGF1 MSC PTH PMC11079205__F2 The GM and gut hormones on bone metabolism TH VIT IGF1 PYY PMC3961644__F8 Proposed model for the negative or positive regulation of chondrocyte maturation or apoptosis by Smpd3/nSMase2, respectively RUNX2 BMP2 ACAN COL2A1 HAS2 COL10A1 SOX9 PMC11033413__F2 Progress of medicinal plants and their active metabolites in ischemia-reperfusion injury of stroke: a novel therapeutic strategy based on regulation of crosstalk between mitophagy and ferroptosis GPX4 NF2 IPP HILPDA HMGCR GLS PMC12154018__F3 Inhibitors targeting the PI3K/Akt pathway, clinically approved for cancer treatment TSC2 TSC1 PTEN EIF4E PMC12154018__F1 PI3K/Akt signaling pathway TSC2 TSC1 PRR5 EGFR PTEN MTOR DEPTOR MLST8 PMC5924546__F3 Wnt signaling pathway regulates deiodinases LRP5 LRP6 PMC1860011__F2 PPARG as a new therapeutic target in inflammatory bowel diseases VCAM1 FOS JUN PMC4184787__F2 Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways SOAT2 MGST2 IL18 PLTP IRF3 TG NCEH1 PMC3409471__F2 Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma EPCAM EGFR APC GSK3B GATA6 PTEN HIF1A ADAM17 NLK LEF1 CDX2 FHL2 ABCG2 STAT3 PMC6949069__F6 The breast cancer pathway KIT BRCA2 PTEN PMC8194146__F5 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer NCOR1 WNT3A EGFR IMP3 SKI WNT5B WBP2 PMC8194146__F7 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer SOX2 PMC4290680__F1 Structural model of and cell signaling pathways triggered by ManLAM and its biosynthetic precursors LM and PIMs IL10 CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR1 CARD9 TLR4 KSR1 SYK JUN TIRAP PMC4290680__F2 ManLAM and PIM action on phagosome maturation and autophagy RAB14 ULK1 MTOR IFNG PMC7227813__F1 Anti-lipolytic action of insulin PDE3B ATM PMC8194146__F2 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer LATS1 MOB1A MOBKL1A LATS2 PMC5710110__F2 Transforming growth factor B (TGFB)-induced Smad signaling pathway GIG8 SMAD2 SMAD4 CDK4 CDK9 CDK8 ID1 ID3 PMC5710110__F3 Transforming growth factor B (TGFB)-induced transcriptional program and its alterations in cancer E2F4 MYC SMAD4 FOXG1 ATF3 CDC2 PMC8194146__F3 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer FOXM1 YAP1 LATS1 LATS2 PMC8194146__F4 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer CRABP2 USP9X LATS1 LATS2 ZNF367 PMC6395693__F5 Transcription factor regulatory effect network identified using Ingenuity Pathway Analysis (IPA) MYH9 FLNA GPX1 MYH7 KDM5A GATA4 DMPK MYH6 HSPG2 HEY2 LDB3 ZYX TCAP NKX2-5 IFI16 PMC8393760__F4 Molecular Aspect of Nephrolithiasis Development OTC ASL PMC8393760__F3 Molecular Aspect of Nephrolithiasis Development APRT XDH PNP PMC6834311__F2 The most common signaling pathways influenced by probiotic strains employed in C PMC7763898__F2 MicroRNAs expressed in periodontitis and their target in alveolar bone MAFB ARHA NFIA PMC7219112__F7 Gene-Concept network plot shows the linkages between differentially expressed genes for MAPK pathway-mutated (versus MAPK-WT) HNSCC tumors and GSEA enriched biological concepts GOLPH3 CXCL3 ZDHHC3 RPSA RPS26 THOC7 WDPCP RPS24 GPAM IFNG RPL12 KPNA4 KIR2DL4 MUC19 CRTAM PARL CST7 GPR171 SLC33A1 PANO1 MS4A3 SLAMF7 FASTKD3 HLA-DRB1 SECTM1 RPL18A PLEKHG5 SIRPG GORASP1 CLEC2B ARPC4 ACKR4 HCST TMEM67 ARHG ERCC1 SPOP SLA2 PHAX KLRC2 XCL2 TBK1 OXSR1 NUB1 PRELID1 GNLY PAIP1 GPX1 PCBP4 FBXO6 ARRDC1 GMFG CNN2 RPL32 RNF123 RPS14 CHCHD4 RPL36 GIPR ARHA RPS11 RPS15 RPS9 APEH RPL29 RPL28 KLRD1 RPL27A PSMB10 SKP2 RPS23 PDCD1 RPS4X ZDHHC4 CLEC4D RNF213 CLEC4E MYD88 TMF1 IFITM1 UBE2D4 RPL23A PLA2G7 TNFSF6 KIR3DL1 BRK1 UBA7 RPS27 SERPINA1 RPL3 CTSL NDUFAF2 EEF2 AIF1 CARD16 RPL18 CACNB3 HRAS LSM3 SEC22C RPL17 RPS13 AZI2 ISG20 ZYX GRPEL2 APOBEC3G RPLP2 USP15 RIOK2 BATF2 NCBP2 CSF3 TRIM21 HAVCR2 GBP5 IFNGR2 THEMIS2 APOBEC3H TTBK1 HLA-DMA RPS2 LILRB2 MT2A GZMA PRF1 PDCD1LG2 RPS6 PLGRKT BAX RPL13a GALNS PRKD2 RPL15 C1QB CISH CD7 IL33 SEC22A GLDC PSME2 ABCD2 PMC3620096__F1 Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles RAB38 TYRP1 RAB32 PMC3127250__F1 Autophagy and the integrated stress response ULK1 ATG12 ATG3 AMBRA1 ULK2 UVRAG ATG10 MTOR VMP1 PMC5557591__F5 Effect of masticatory stimulation on the quantity and quality of saliva and the salivary metabolomic profile ARG2 OTC ACD NAGS HEL-S-20 MDH2 PMC6052717__F2 Signalling pathways involved in ccRCC SMO IL6 STAT3 PMC4324684__F9 Proposed pathway of cytosolic jadomycin-induced ROS and their metabolism within MCF7 breast cancer cells DDC HEL-S-44 PRX PMC3670238__F1 Spectrum of STAT functions in mammary gland development PIK3R1 CD14 SOCS2 SOCS3 IL13RA1 LIF SLPI IGFBP5 HMFT1766 PRL PRLR PIAS1 TYK2 JAK1 GATA3 SOCS1 PMC7918168__F6 Action mechanism by gallic acid and rutin on mitochondrial functions in C2C12 myotubes MFN1 MFN2 NRF1 NDUFB3 MUL1 DKFZp686F0183 TFAM FIS1 OPA1 SDHB PMC6140703__F8 A schematic model of GC development BAD PLK1 CCND1 PMC7461761__F1 Evolutionary Origins of Programmed Cell Death Signaling TRADD APAF1 RRS1 RIPK3 ZAR1 CASP8 FADD MLKL GSDMD PMC5591063__F4 Changes in Adipose Tissue During Weight Gain CCL5 CCL2 PMC6187096__F2 Ginsenoside Rh2 epigenetically affects genes in the cell-mediated immune response pathway ANK2 CTBP2 CASP12 HSBP1 ARHGAP18 HEL-S-15 KDM5A CD69 BAZ2B CARD18 RIMS1 RASGRP3 CHRM1 PNKD RAB26 DGKZ PANX1 SOX6 GNRH1 CASP5 RASGRP4 PMC6517553__F3 General principle of the HSV-TK suicide gene system ATM TNF FADD PMC7060917__F4 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang EPO BCR MBP APC CD40 PMC7060917__F5 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang PDE4D KDR EGFR PPARG PMC5512555__F3 Notch signaling in the mammalian ovary HSD3B1 NOBOX BMP15 JAG2 LFNG CYP11A1 RAC1 ZP3 FOXI2 FOXL2 GATA4 FIGLA GJA1 DLL4 STRA8 GJA4 INHBA STAR STAT3 PMC3823599__F7 MiR-103 Controls Milk Fat Accumulation in Goat (Capra hircus) Mammary Gland during Lactation DGAT1 SCD ACACA ABCG1 LPL ACSL1 ABCA1 ACOX1 FASN CD36 PMC7221190__F2 Complement-driven accelerated renal senescence after IRI-AKI leading to CKD progression HEL-S-62p ICE1 CS LRP5 LRP8 TGFA CP PMC8847224__F2 Dissecting the Crosstalk Between Nrf2 and NFKB Response Pathways in Drug-Induced Toxicity RELA RELB TNF LTBR PMC12079202__F6 Overall network diagram of “drug-target-disease-pathway” PLAT PTEN BAX PMC10607277__F9 Compound–disease–therapeutic targets-core pathways network; red triangles represent diseases, blue triangles represent compounds, purple ovals represent pathways, and green ovals represent targets MAPKAPK2 HSP90AB1 GSK3B BCL2L1 RAC1 FOXO1 MMP3 PRKCB CDK2 RELA BCL2 HDAC2 CDK4 HEL-S-72p IL1B PMC11022503__F8 Proposed mechanism of erroneous differentiation of TSPCs under high glucose HMGB1 RUNX2 COL1A1 TNMD SCX PMC6612049__F1 Mechanisms of ionizing radiation sensitizing and resistant effects in various subtypes of breast cancer and irradiation-induced apoptosis UBE2D3 EGFR LCN2 BCL2 RAD51 MTOR BRCA1 BAX PMC4136419__F1 Targeting the B cell receptor signaling pathway in B lymphoid malignancies BTK CARD11 BCL10 LYN MYC SYK PLCG2 CD19 PMC4136419__F2 Targeting the B cell receptor signaling pathway in B lymphoid malignancies BTK IL7 BACH2 BASH RAG1 LYN MYC SYK RAG2 CCND2 PMC9221006__F3 Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers MMP9 HIF1A MTOR SOX9 HEL-S-68p IFNG MMP2 CCND1 JAK1 SP1 HEL-S-133P IRF-1 STAT3 PMC4698274__F1 Innate Immunity against Leishmania Infections HEL-S-62p NLRP3 IL18 TLR9 MYD88 IL1B TLR3 PMC10377042__F2 Potential Influence of Uremic Toxins on the Homeostasis of Bones and Muscles in Chronic Kidney Disease AHR UCP1 PTH PMC9312989__F6 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies PIK3R1 RIT1 BRAF ALK EGFR PTEN MTOR HRAS TSC2 NF1 RET TSC1 MAP2K1 ERBB2 STK11 PIK3CA ROS1 PMC4536957__F2 Schema showing the multiple functions of FOXD1 lineage myofibroblasts in interstitial kidney disease MMP7 ADAMTS2 MMP14 ADAMTS12 TIMP1 FAP SHH PMC7796309__F1 Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease BACE1 C9 HEL-S-11 HBD PMC7661798__F4 Cellular response to growth factor (GF) via its receptor PIK3CA PTEN MTOR PMC6111708__F2 Hippo-YAP signaling and the pathogenesis of gastric cancer AKR1B10 ADAMTS12 SLC26A7 ASPN ADH7 COL1A1 ORM1 UGT2B15 GKN2 PGA5 HPGD CYP2C18 FAP TCN1 MFAP2 RASSF6 FNDC1 SFRP4 SST HEL110 THBS4 THY1 SULF1 CAPN9 FOV CYP2C9 THBS2 PGA3 TFF2 ORM2 CTCFL TFF1 ATP4B CNTN3 ALDH3A1 COL10A1 PMC9312989__F3 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies AMER1 TLE3 SFRP4 RNF43 DKK3 APC GSK3B LRP5 MYC LRP6 TCF7L2 DKK1 DKK2 WIF1 SFRP5 DKK4 TLE4 AXIN1 SFRP1 TCF7L1 TLE2 PMC3307371__F8 Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus GSK3B GSK3A BDNF HSF1 PMC4667791__F5 MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation () CYP4F2 CYP4Z1 CYP4X1 CYP4A11 PMC8626287__F2 Implication of the circadian clock in the regulation of neural signaling and behavior NOTCH2 TSC2 TSC1 HOMER1 MTOR BDNF PER2 PMC8204249__F5 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms MSC TPO CCL4 TNF IL1B CCL3 PMC11987923__F3 Tumor immune microenvironment in cholangiocarcinoma APC FGFR2 PMC8204249__F3 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms TRADD RIPK3 TNF CASP8 FADD MLKL PMC8204249__F4 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms IRAK1 RELA S100A8 TPO IRAK4 MYD88 FLT3 TNF MPL CDK6 PMC10218668__F1 Therapeutic peptides for lung diseases NLRP3 FGF21 CNP VIP PMC3381956__F1 Signaling pathways and their targeted therapies in NSCLC TSC2 EGF KIT TSC1 HGF EGFR STK11 SRC PTEN HIF1A MTOR FADD PMC4598753__F1 Nuclear receptors can alter NFKB signaling and activity TLR4 TRAF6 IRF3 MYD88 PMC3495118__F1 Transcriptional regulation of the cytoprotective phase 2 genes under control of the transcriptional factor nuclear factor-E2 p45-related factor 2 (Nrf2) CS KEAP1 PMC7750564__F1 NFKB signaling pathway is involved in the transcription of HIV which can be exploited for HIV cure studies BIRC2 HEL-S-34 BIRC3 TRAF3 RELB RAF1 TRAF2 PMC7072180__F4 FUT8 overexpression promotes DNA replication FUT8 RPA3 CDK2 PCNA MAL PMC6068284__F3 Fumarase functions in the human and yeast DNA damage response (DDR) to double-strand breaks (DSBs) FH SETMAR PMC7281640__F2 Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma GNA11 EIF1AX BAP1 PMC9144890__F5 CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling CD44 MRE11A PMC1839891__F10 In this model, the tumor growth process is replaced with the cell cycle model from figure 7 APC GSK3B CCND1 SMO CDC2 PMC9832433__F4 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis IL16 TLR4 PC MPO APC TF PMC6180192__F1 Nuclear factor erythroid 2-related factor 2 (NRF2) activation CS KEAP1 SKP1 RBX1 PMC9832433__F2 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis TLR4 MPO VCAM1 F2 HEL-S-133P FOXO1 PMC9709224__F7 Oleic acid-induced steatosis model establishment in LMH cells and its effect on lipid metabolism APOB TG MTTP FASN PMC6094051__F6 Models for Golgi fragmentation induced by truncated APC APC ARHA RHO APC2 PMC8564353__F1 Exosome CTLA-4 Regulates PTEN/CD44 Signal Pathway in Spleen Deficiency Internal Environment to Promote Invasion and Metastasis of Hepatocellular Carcinoma CD44 PTEN PMC8204249__F1 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms HEL-S-99n TPO MPL STAT3 CBL SH2B3 PMC4983011__F1 Processes involved in particle-induced pro-IL-1B expression HMGB1 IL33 PMC5830721__F5 HIF-1 signalling pathway is enriched in proteins containing labile disulfide bonds TLR4 FRK VHL IL6 TFRC EIF4E KHK HEL-S-87p MTOR HEL-S-133P STAT3 PMC7859462__F4 Impact of 3′UTR APA on its target mRNA and protein CD47 SET RAC1 PMC8860994__F8 Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence FYN TRADD GAB2 RHO PTEN TNF TRAF2 SMS BAX PMC7355051__F3 Targeting mitochondria using endogenous cardioprotective strategies MFN2 GC GSK3B STAT3 PMC7490471__F1 ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway EGF WWC3 EGFR GRB2 MAPK1 PMC5173116__F7 Reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux OCEL1 PC MTOR PMC5007556__F1 SPATA2 – Keeping the TNF signal short and sweet TBK1 TRADD RELB TNF RPS6KB1 RIPK1 LIMCH1 CYLD SHARPIN SPHKAP EXOC4 TMOD3 TRAF2 CCAR1 MLKL STAT3 AKT3 PMC5899030__F3 multiple neuropeptides and receptors regulate the activity of neurons in feeding circuits POMC PC NPY AgRP MC4R GPR171 GPR83 PMC5770878__F6 The hypothesized protective effect of CR on retinal degeneration by ONVT: the pivotal role of elevated endogenous 3HB via ketolysis CS ACAT1 BDH1 NQO1 PMC534909__F2 Fas receptor pathway of apoptosis CAD FADD PMC9484011__F2 Biosynthetic pathway leading to H2S production from L- and D-cysteine DAO PMC534909__F3 Cell survival signaling pathways BAD BAX PMC3903252__F7 Schematic illustration of the TGFB/ENaC pathway in a generalized alveolar epithelial cell monolayer, described in this study PC SMAD2 NOX4 PIP5K1A PMC7069061__F6 Pathway of multiregulatory effects in Chinese medicine CXCL1 EGF NGF EGFR TPO PTEN MTOR IFNG MMP3 TNFSF6 SRC IL2 MAPK1 CD40LG IL4 CXCL11 BAX IL10 CXCL10 VEGFA ARHA IL6 IL5 RAI1 CASP3 IL7 IGF1 IL3 BCL2 RAF1 PMC10310766__F2 Canonical pathway of p53 that regulates ferroptosis ELAVL1 GPX4 SLC7A10 SLC7A11 DPP4 SLC25A28 ALOX15 GLS2 FDXR PMC10310766__F3 Noncanonical pathway of p53 that regulates ferroptosis SLC7A11 ALOX12 HEL-S-5 PMC2674747__F1 Illustration of differences in the expression of genes for early steps of sphingolipid metabolism using a KEGG-based microarray analysis tool (GenMapp v2.1) that has been modified to display this pathway more completely (www.sphingomap.org) ASAH2 CERS3 LASS1 CERS5 SPHK1 CERK SPHK2 CERS2 SGPP2 PMC9307469__F1 Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients? IRF7 IFNAR2 FURIN IFNAR1 ACE2 TMPRSS2 FOXP3 PMC6935429__F3 Different DNA repair mechanisms RAD18 PCNA PMC5507876__F8 The diagram of rGal3C regulating NDRG1 through integrin/FAK/SRC pathway SRC PMC3592845__F7 Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets SHH IL1B PMC6493027__F2 Ingenuity Pathway Analysis (IPA) of ASS234 treatment PIN1 HEL-S-28 APC CD44 DKK1 RHO MAP3K7IP1 WIF1 NLK MMP7 MDM2 SFRP1 TCF4 PMC5874277__F3 Phospholipase D1 and neurogenesis of neural stem cells PC CDC42 HPCA STAT3 PMC9253713__AF1 SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway FACL4 SUFU NF2 LATS1 PMC6738809__F6 Mechanisms involved in vitamin D-mediated immunomodulation of neutrophils SOCS3 NR1i1 TRAF6 MYD88 CYP27B1 MAL PMC8842010__F4 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data IL3RA NGF PPP3CC MAPK3 RALA FGFR4 BCL2L1 RALBP1 FGFR2 VAV3 FGFR1 MAPK1 SOS2 VAV1 RALB HRAS PIK3R3 PRKACG TIAM1 PIK3R5 RAC3 PAK1 PPP3R1 INSRR AKT3 CDC42 CHUK BAD MAP2K4 EGFR PPP3R2 CSF2RB ARAF JUN PDGFRA NTRK1 FGFR3 MAP2K2 RAC1 IKBKB NFKBIA MAP2K1 NFKB1 IL3 RELA PIK3CA RAF1 SOS1 VAV2 PIK3R2 PMC3855094__F13 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects HGF INS TGFA IRS1 PMC9301819__F5 Atopic dermatitis and Psoriasis vulgaris -specific DEGs segregate discretely based on unbiased pathway and network analysis SYNE2 CD99 NBAS IFITM2 NRIP3 ITM2C AHNAK LAG3 IL17RB TSHZ2 RPS26 METRNL IFITM1 SOX4 FYN ZFP36 RPL36A TGFBR3 CPM MMP25 PLP2 PRKX SFXN1 SNX9 PTPN13 CTLA4 CTSH CLEC2B RPL17 ZFP36L2 MGAT4A TIMP1 TWIST1 BTG1 B3GALT2 HEL-S-66 TUBA1B TMEPAI ARHGAP21 FANK1 TNFAIP3 SLA2 THADA ACTG1 SLC5A3 GALNT1 ODF2L LONRF2 PTMS PNRC1 NAP1L4 F2R GNLY CCR6 ARHGEF12 IL17F GBP5 TRPS1 PPDPF CHN1 LPCAT2 CLU CEBPB CXCL13 CEBPD UBC ISG15 BIRC3 CD2 GABARAPL1 JUN GATA3 CSGALNACT1 RBPJ ANXA1 FTH1 MFHAS1 CCRL2 DAPK2 SPOCK2 LMO4 CRIP1 KLRB1 TNFSF10 CD7 SOS1 YPEL2 PMC2864813__F4A Substance P in Polymicrobial Sepsis: Molecular Fingerprint of Lung Injury in Preprotachykinin-A−/− Mice SOCS3 CCL13 FPR1 MMP9 S100A8 IL1RN LCN2 PTPN11 S100A9 IL1B SAA2 CCR1 PMC8842010__F6 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data BRAF FLNA APC MYC SMAD4 HPSE PKMYT1 NLK DAAM1 CREBBP EP300 IQGAP1 EVI1 CCND1 JUND CDC2 HEL-S-93 PRKDC MYT1 PMC7156871__F3 MicroRNA (miR)‐302/367 family participates in networks that regulate cancer hallmarks DCUN1D1 IGF1R SDC1 MICB EGFR RAB23 LATS2 E2F3 CCND2 NR2F2 CXCR4 CCND1 MICA RYR3 CDC2 MTDH MCL1 BAX PMC4139671__F5 Wnt/Beta-catenin signaling pathway LEF1 APC GSK3B PMC3283604__F6 TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice TSC2 TSC1 IL7R MTOR PMC8157020__F1 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer MTOR PMC5905598__F4 Genes of complexes coding for the mitochondrial oxidative phosphorylation and tricarboxylic acid cycle (TCA) ME2 CS TIMMDC1 COQ3 NDUFB8 NDUFA6 FH NDUFA9 NNT SDHD NDUFB5 MDH2 PMC8157020__F2 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer FYN FZD2 IL6 STAT3 PMC4732299__F5 Alterations in the levels of metabolites and mRNA transcripts that are crucial to energy metabolism in NAF-1(−) MCF-7 cells ME1 PIG59 CRAT GIP MDH2 NAF1 SCD ACADVL ACACB ACO2 ACLY ME3 PCK2 HEL107 HEL-S-133P FASN PMC10572209__F7 Molecular pathways in Hep3B cell line BAD MAFK INS CDK4 PTEN PMC11397714__F3 IFN signaling activates the JAK-STAT pathway, leading to the transcription of genes involved in the immune response (Created with https://www STAT1 STAT2 IFNK IRF9 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IRS1 IFNLR1 PMC6027339__F2 Chronic active BCR signaling in lymphoid malignancies BTK BCR BASH LYN SYK PLCG2 CD79B CD79A CD19 PMC4819199__F7 Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans PMC4693877__F2 Bacterial components that affect innate and adaptive immunity in the intestine PDC AHR PMC11848412__F5 A, Schematic illustration of how calcium dysregulation in the aging association cortex leads to activation of calpain‐2 and an exacerbation in sporadic AD pathology LIMK1 ROCK1 CDK5 APP RYR2 PMC11397714__F1 Canonical TNFA signaling pathway activates NFKB through TNF receptor binding, involving TRADD, RIP-1, and the IKK complex, leading to the transcription of various genes that are involved in the immune response (Created with https://www RELA TAB3 PMC6417013__F1 Main aspects of folate receptor signaling and C1 metabolism discussed during the meeting SHMT1 HEL-S-51e MTHFD2 STAT3 PMC11397714__F2 IL-1B signaling pathway activates NFKB and MAPKs through the IL-1 receptor, leading to the transcription of genes involved in inflammation and immune responses (Created with https://www IRAK1 TRAF6 MYD88 MAP3K7IP1 PMC9017388__F6 SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells PIK3R1 BAD MAPK3 PRKAA1 AKT1S1 EIF4E MTOR EIF4EBP1 EIF4G1 PDPK1 TSC2 PRKCA RPS6KB1 PPP2CA PRKAB1 PMC8476782__F2 Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target FYN MMP11 SATB1 NOTCH1 SP1 PMC2596750__F8 TNFR1 and LTBR ligation-induced signaling in vascular EC CXCL2 CXCL12 TNF LTBR PMC7225294__F11 Proposed model of action and mechanism by which CVB3 infection causes cardiomyocyte death ISG15 DSG2 IFNB1 DSC2 MAVS PMC10873402__F5 JAK-STAT signaling pathway PIK3R1 IL21R EPOR GHB3 EPO IL6R OSMR IFNG IFNL2 STAT1 IL7R GHR IFNA2 IFNGR1 IL10RA CSF2RA IFNW1 SOS2 STAT2 IRF9 IL20RB TSLP THPO IL12B IL10RB IL15 LEP IFNK IL2RG GH1 IL2RA IL11RA AKT3 IFNA17 IL5RA IL22RA1 IL17D IL11 IFNL1 IL12A IFNLR1 LEPR IL4 IL2RB IL10 IL24 IFNB1 IL7 IL3 STAT4 IL15RA JAK3 TYK2 IL20 OSM PIK3CD IL3RA IFNA21 STAT5B CNTFR CTF1 IL9R CSF2 IFNL3 IFNAR2 IFNAR1 HRAS IL23R PIK3R3 IL12RB1 GRB2 IL27RA MPL IL13RA1 IFNA1 IFNA4 CSF3 IL9 CSF3R IFNGR2 CSF2RB MTOR IFNA5 IFNA7 IFNA8 IFNA14 IL20RA IFNA16 CRLF2 IFNA10 PTPN11 IL2 STAM2 PTPN6 IL13RA2 IL13 LIF IFNE IL6 IL5 PRL CNTF IL22RA2 PRLR IL23A PIK3CA IL6ST IL-21 RAF1 JAK1 SOS1 PIK3R2 STAT3 PMC10873402__F4 Enrichment analysis for leading target genes PSG11 MSC PMC8846289__F1 Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party MICA IFNG PMC4135580__F7 Working model for the PEX5L-PEX7-mediated import pathway PEX7 PEX6 PEX5 PEX16 PMC2737901__F1 Putative biosynthetic pathway of PUFAs in Mortierella alpina 1S-4 TNLG7C COCH GLA PMC5391973__F4 The immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity CD14 IL16 IRF7 LBP MOK CD40 IRF3 MYD88 MAP3K7IP1 JUN IL1B TIRAP PMC8065571__F1 Schematics of the eicosanoids synthesis pathway for the production of prostanoids (Prostaglandins—PGs, Prostacyclin and Thromboxanes—TXs), Leukotrienes (LTs) and resolving mediators including D- and E-series resolvins (Rvs), protectins and maresins COX2 LTA COX1 LTB PMC4837237__F7 A simplified overview of the ectodysplasin/EDA‐receptor/nuclear factor kappa B (EDA/EDAR/NF‐KB) pathway EDARADD EDAR TNLG7C PMC3051261__F11 Schematic Models of Tap46/Tap42/A4 Functions in TOR Signaling Pathways in Eukaryotes.(A) TOR signaling in yeast EIF4E RPS6 MTOR PMC8706757__F2 Necroptosis in disease and treatment RIPK1 TLR4 TRADD TRAF5 CYLD RIPK3 TRAF2 FADD TLR3 MLKL TAB3 PMC1964512__F3 Type I IFN innate immune response to adenovirus-mediated IFNG gene transfer contributes to the regression of cutaneous lymphomas CORT PLSCR1 SOCS2 IFNA1 LGALS9 CCL2 CCKAR SP100 NCR3 FGF9 STAT1 SP110 OAS1 OAS2 XCL1 MNDA FAT10 NMI AIM2 RSAD2 IRF7 CXCL10 CCRL2 SNAP23 GAS2 DBP CCL20 CXCL9 RORA CCL22 CASP4 PMC8372151__F3 Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease—A Pediatric Perspective FGF23 PTH FGFR4 PMC9569955__F7 Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation IFIT3 TBK1 UBE2F TRAF3 ABCF1 TRAF6 IRF3 TRIM25 MAP4K1 STAU1 BCR VCAM1 BASH MAVS PMC6027339__F1 Oncogenic MyD88 mutations activate the canonical NFKB pathway IRAK1 TRAF6 IRAK4 MAP3K7IP1 PMC7765482__F8 Canonical pathways identified from protein co-expression network SNCA USP2 MAP2K4 HEL-S-71 HAVCR2 MARK1 SERP1 IFNAR1 PDPK1 PRKCA PRKCB HEL-S-67p CRLF2 BIK BIRC3 LYN GRB2 SRC BCL2 MAPK1 CDH2 IFNGR1 TGFB1 CP PMC3612391__F2 Role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development SEMA3E PMC5747488__F13 Parapoxviral virion protein targets the retinoblastoma protein to inhibit NFKB signaling TRADD MAP3K7IP1 TRAF2 TAB3 PMC3731808__F6 Comparison of gene expression changes in human bladder cancer and our mouse model based on KEGG pathway analysis EREG EGF HEL-S-79 MMP11 VEGFA MYC FGFR3 MAP2K2 RB1 HRAS CDKN2A MMP3 CDKN1A CDKN2B MDM2 CCND1 CDK4 THBS1 PMC5790345__F5 PD173074 inhibits the signal pathway downstream of FGFR1 in ESCC STAT1 FGFR1 MTOR PMC4752998__F1 Epithelial/mesenchymal status of MCs is due to the balance of signals delivered by multiple receptors HGF SMAD2 BMP7 RHO SMAD1 IL1B DKFZp781O1323 STAT3 PMC3429478__F1 Development of Quinoxaline 1, 4-Dioxides Resistance in Escherichia coli and Molecular Change under Resistance Selection FES TG PMC5611863__F1 Landscape of new drugs in lymphoma TXK FOS EGFR TEC BLK CD79B CD79A ITK BTK CARD11 ERBB4 BCR BASH ERBB2 BIK LYN BMX SYK JAK3 JUN CD19 PMC4185881__F1 Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, InterferonB and Proinflammatory Cytokines in Sepsis TBK1 CD14 TLR4 IRAK1 LBP TRAF6 IRF3 MYD88 CSA2 MAP3K7IP1 MAL PMC8997162__F1 Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer FGFR1 ERBB2 ERBB3 EGFR FGFR3 FGFR4 PTEN FGFR2 PMC8976706__F4 Decellularized extracellular matrix mediates tissue construction and regeneration LATS1 LATS2 PMC4410875__F3A Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer PTEN PMC3633815__F1 MTOR signaling pathway TSC2 ULK1 TSC1 RHO SGK1 RHEB PMC2674738__F1 Circulating blood monocytes adhere to activated endothelium at sites of disease or injury CCR2 PC LPA PMC6373401__F1 Neuroprotective mechanisms of antidiabetic drugs in the context of Parkinson’s disease dementia IGF1 IL1R1 MTOR BDNF PMC8812204__F2 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke RAP2B ULK1 ATG16L1 TFEB ATG12 SQSTM1 LAMP2 MTOR ATG14 DKFZp686F0183 NBR1 PMC8812204__F1 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke ULK1 ATG101 BNIP3 ATG14 RHEB PMC7330432__F1 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway RRM2 PCNA PMC11547832__F8 DOE is involved in the Akt signaling pathway to regulate protein synthesis and lipogenesis UCP1 MYH2 IRS1 PMC8432143__F2 Moving towards clinical trials for mitochondrial diseases POLG PARP1 POLRMT TFAM PMC7012475__F1 Monocytes in sickle cell disease PIGF TLR4 VCAM1 MIA TF PMC6486704__F2 Chemoautotroph Ca GNS NONO NDP PMC5615340__F5 Crosslinks between integrin and wnt signalling HEL-S-28 GSK3B PMC2909359__F8 Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest ITK CSF1R FOXD3 DCT PMC8889909__F2 Physiological and Pathophysiological Roles of Metabolic Pathways for NET Formation and Other Neutrophil Functions HEL107 RPE PMC9478117__F8 MiR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGFB signal pathway SMAD2 TGFBR1 TGFBR2 SMAD4 CROT PMC8445727__F8 Active Ingredients and Potential Mechanisms of the Gan Jiang-Huang Qin-Huang Lian-Ren Shen Decoction against Ulcerative Colitis: A Network Pharmacology and Molecular Docking-Based Study EGF BAD HGF VILL AXL BAX PMC10610499__F5 Interplay between EVs and the TLR4 signaling pathway in the context of HCC HMGB1 TLR4 S100A10 EGFR PMC11990295__F5 Anthocyanin in modulating PI3K/Akt/FOXO pathway in obesity GCK FOXO1 PMC10610499__F3 Liver manages a complex antigenic load from the blood, relying on immune tolerance mechanisms and mainly LPS tolerance TLR4 TRAF6 MYD88 PMC4515857__F3 PTEN localization and interactions with representative partners APC CENPC MC1R PTEN PMC10610499__F2 TLR4 downstream signaling pathways CD14 TLR4 TRAF3 LBP TRAF6 IRF3 IL6 MYD88 PMC5446300__F4 T-Lymphocyte Homing: An Underappreciated yet Critical Hurdle for Successful Cancer Immunotherapy CXCR3 CXCR1 CXCL1 VCAM1 CD44 IL8RB TNF IFNG PMC3898353__F1 Complement activation pathways HEL-S-62p CD59 C9 CFB CFD MASP1 CFH VTN C7 C6 CR1 CFI PMC3410851__F9 Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System FGF10 TBX5 WNT2B TBX4 FGFR2 SPRY2 SOX9 BMP4 PMC8522100__F2 Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing RET BRAF ALK NTRK1 NTRK3 PMC11672291__F7 The potential mechanism by which intracellular PC capsules exert anti‐inflammatory effects by inhibiting apoptosis COX2 PC UNK BAX PMC4232400__F5 E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice PTDSS1 LPCAT3 CHKA CHPT1 PCYT2 PISD PTDSS2 PEMT PMC6920321__F2 NFKB Signaling Pathway(Left) Canonical pathway of NFKB activation BCL10 EGFR RELB CD40 MYD88 REL TNF TRAF2 LTBR STAT3 PMC3815777__F2 Putative intracellular cascades activated by cyclic di‐nucleotides TLR7 TLR9 TRAF6 IRF3 TYK2 TLR3 MAVS TIRAP PMC4730273__F3 The tryptophan (TRP) metabolic pathway HAAO HEL-S-90n KYNU KMO PMC11464522__F2 Molecular mechanism of ferroptosis in RCC GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 DPP4 PDIA4 DPP9 OGT ATF4 KLF2 MLYCD SLC3A2 AIM2 TF PMC11464522__F1 Ferroptosis GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 SLC3A2 TF PMC11464522__F4 Molecular mechanism of ferroptosis in BCa HEL-S-89n GPX4 LPCAT3 STEAP3 FACL4 LACTB SLC7A11 PISD WTAP FLRT2 PHGDH ST6GALNAC6 HEL-S-102 PCBP1 SLC3A2 PPARG EMP1 TF PMC11464522__F3 Molecular mechanism of ferroptosis in PCa GPX4 LPCAT3 CEMIP STEAP3 FACL4 SLC7A11 HNRNPL DECR1 RB1 MTOR PHGDH IFNG STAT1 SGK2 TFEB SOX15 SLC3A2 TF PMC7484992__F1 Signaling pathways activated by CXCR4 ACKR3 SRC CXCL12 MTOR PMC2860937__F1 Caveat mTOR: aberrant signaling disrupts corticogenesis BRSK1 PTEN EIF4E MTOR RHEB PMC8533503__F2 Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention NAMPT TFAM UCP2 PMC4302085__F1 Networking of the PI3K/Akt/mTOR signaling pathway EGF RICTOR IGF1R EGFR MDM2 CCND1 PTEN MTOR RHEB PMC3441384__F4 Nanoparticle-induced autophagy ATG12 MTOR DKFZp686F0183 PMC2858611__F3 Depiction of the “Reelin signalling in neurons” pathway generated by Ingenuity FYN VLDLR LYZ GSK3B APP DAB1 ITGB1 MAPK8IP1 APOE CRKL PMC4302085__F2 Proposed mechanisms accounting for resistance to inhibitors of the PI3K pathway IGF1R EGFR MTOR IRS1 PMC6480472__F1 Diagram of microRNAs and their involved pathways to cancer hallmarks CKS1B ZEB2 EGFR MDM2 GRB2 CD80 PTEN CTLA4 MTOR HEL-S-133P ROS1 STAT3 PMC8905141__F5 Transcriptomic and Metabolomic Analyses Reveal the Differential Regulatory Mechanisms of Compound Material on the Responses of Brassica campestris to Saline and Alkaline Stresses HPD FH ACLY SDHB PMC6714206__F7 Mechanism of PB2 on the protective effect in liver fibrosis VEGFA SMO PMC2238789__F4 Neuronal pathway containing proteins found in Lewy bodies TH SNCA NPC1 MAP2 NEFH CLU HEL-S-102 NFKBIA MAP1B C7 HEL-S-44 CALB1 SYP CYCS NEFL PMC2238789__F3 Hypothetical ‘super pathway’ not stratified for cell type illustrating known direct interactions between the 892 PD priority genes (regulation, expression and promoter binding only) TH CACNA1B GEM GSK3B SYT3 NEFH ACHE SNCG AMPH SNCA RELN RAB11A ADAM23 DLD SNAP25 VAMP2 SLC6A3 RTN1 PCSK1 GNAO1 SNCB HSPA1A HEL-S-93 NAPG TF CDC42 NEFL PMC3571341__F12 Proposed model of M-CSF-mediated organization of the osteoclast cytoskeleton VAV3 SYK GIP PMC2238789__F2 a Cell processes predicted to be influenced by the top up-regulated priority genes (164 genes showing a differential expression >1 log2) based on in silico analysis employing the ResNet database (PathwayStudio 5.0, Ariadne) MAF RELN NLN ID3 CP BOK PMC7820501__F4 Summary of the molecular processes during COVID-19 infections that are affected in DS IL10 RNASEL STAT1 RNASE1 BST2 CXCL10 FURIN ACE2 TMPRSS2 PMC2238789__F5 Interactions of known PD genes (marked yellow) with the priority genes of this study TH SNCA SNCG PIN1 SNCB EN1 SYP THY1 PMC12066314__F9 Proposed model showing that apigenin promotes pigmentation through the c-KIT/Raf-1/MAPK/CREB signaling pathway MLPH RAB27A GRB2 CRTC1 IRS1 CDC42 PMC8222328__F4 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction POR CAD PMC8222328__F2 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction CORT ATM ZFP1 CAD GLS PMC11586126__F4 CLACs are most significantly enriched in neurological pathways, including (A) glutamate receptor signaling pathway and (B) axon guidance signaling pathway TH ASCL2 ROBO1 NEUROD1 ROBO2 KIN ZIC2 HEL-S-20 ZIC3 MYOG PMC3762983__F2 Example of a pathway reconstruction experiment BMP10 SMAD2 BMP15 TGFBR2 BMP5 SMAD4 PMC4891133__F7 Sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met SUFU SHH SMO PMC7859355__F8 Schematic depiction of our proposed model of the role of ROS in the regulation of FGF2-induced AKT phosphorylation in hPSCs FGFR1 FGF2 PTEN PMC3782205__F2 Nephrin-adaptors complex FYN TRPC6 CD2AP PMC11007890__F5 Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma MMP7 SET APC GSK3B HDAC2 EZH2 HDAC1 STAT3 PMC8051677__F6 Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties CTSS CS HEL-S-97n HEL-S-99n GNPDA1 HEL-S-128m PRDX3 HEL-S-32 MDH2 AK2 TXNDC12 HEL-S-26 HEL-S-2a ACAT1 PDHA1 ACO2 HEL-S-44 IMPDH2 PRDX5 PCK2 ARG1 HEL-S-133P ETFA HEL-S-114 HEL-S-30 EEF2 HMGCL GSTM1 CTSH SLC16A3 HEL-S-130P GLRX HEL-75 ACLY SRXN1 PMC9334851__F1 Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate–Adaptive Immune Responses CD47 CD46 BCR HEPACAM CD40 PANX1 CD69 CD19 PMC6290138__F2 Hypusine–polyamine pathway in human neuroblastoma MAT1A SMOX SRM PAOX DOHH DHPS SMS PMC4164328__F3 Intracellular pathway associated with IGF1R activation IGF1R IGF1 IGF2 INS MTOR IGF2R PMC4164328__F2 Intracellular pathway associated with GHR activation in hepatocytes IGF1 EGFR GHR PMC8516344__F4 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation CSA2 AKAP9 PMC8516344__F3 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation BDNF RYR2 SPRY2 PMC7699713__F1 Redox Potential of Antioxidants in Cancer Progression and Prevention GRB2 UNK PMC8487963__F1 MDS and current therapeutic options EPOR EPO IKZF1 SMAD2 PMC7699713__F2 Metabolic regulation of antioxidants: Highly proliferative cancer cells rely on glycolysis to meet its exceedingly high energy demands TIGAR HEL-S-26 PMC9356074__F1 NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism NAMPT HEL-S-90n NADK NNMT PNP NRK PMC4942931__F9 Pathway analysis using IPA software suggests B3-adrenergic receptor signaling activation in T1D-MSCs, with upregulation of several downstream molecules GRK4 GRB2 SRC ADRBK1 STAT3 PMC5638116__F3 Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer EGF EGFR MYC MDM2 RALBP1 MTOR HSF1 CDC42 PMC5638116__F2 Mechanism of synergistic action of VCN-2 and docetaxel (DTL) IGF1R CYP3A4 EGFR CCNB1 SHH CCND1 CDK4 CDC2 PCNA BAX PMC8118237__F1 Intracellular and intercellular iron trafficking in the tumor microenvironment SLC7A11 CD44 IL6 FLVCR2 IFNG PMC6540260__F1 T-cell suppression and immune checkpoint blockage in tumor and organ rejection APC JAK3 CD80 MTOR PMC10669226__F4 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages signaling pathways is predicted to be upregulated in EVPs from aged animals STAT1 SIRPA MAPK4 MARK1 TNF IFNG NCF2 PMC9445052__F7 Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows IL10 IL6 TNF MTOR IL12A IL12B IFNG IL18 CD163 ARG2 CD80 NOS2 IL4 CSF2 CSF1 PMC11566422__F3 ENO1 and its targeted therapy in tumors MMP7 SIRPA CD47 SOX2 FGFRL1 FAP CMTM6 CD44 CCND1 SRC ENO1 PMC11566422__F2 ENO1 and its targeted therapy in tumors MMP7 SOX2 CD44 CCND1 ENO1 PMC5983129__F7 Cisplatin treatment to the induction of apoptosis CDK2 ATF4 ATF3 PMC3942282__F1 The molecular mechanisms and pathways of BBR in reducing oxidative stress and inflammation RHO NQO1 UCP2 PMC10669226__F3 Cardiac Hypertrophy Signaling pathway is predicted to be upregulated in EVPs from aged animals MAPKAPK2 ATF2 IL6 RHO MTOR MAP3K7IP1 ADSS IRS1 RPS6KB1 IGF1 RPS6KA1 GRB2 JUN PMC2767105__F2 Intracellular ascorbate (Asc) modulates redox-sensitive signaling pathways in microvascular endothelial cells during sepsis STAT1 IRF-1 IFNG PMC2747759__F1 Monoclonal antibodies in the treatment of pancreatic cancer FADD BAX PMC8770286__F2 Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development SIAH1 LATS1 SIAH2 LATS2 PMC8342713__F7 Inhibitory mechanism of APG-1252 and gemcitabine against nasopharyngeal carcinoma STAT3 PMC8277227__F1 Interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis HMGB1 MYD88 IL1B PMC5732353__F4 Schematic representation of DAPs associated with theanine (A) and flavonoid (B) biosynthesis GC F3 GLS PMC5932588__F1 Molecular mechanisms that connect cellular junctions to the Hippo pathway PATJ AMOT ZYX PALS1 CRB3 MOB1A CAD LIMD1 PMC4107103__F6 Hypothetical model of molecular determinants of CLL cell survival, proliferation and migration in the PB, BM and LN microenvironments RELB CD44 CXCR5 IL6 BATF CCND2 CXCL13 BTK BCL2A1 BCR FCER2 CXCR4 TRAF1 RELA CCR7 SYK CXCL12 TRAF2 CCL3 PMC8533985__F7 Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model ROCK1 MSC ARHA PMC5299404__F4 Mediterranean versus Red sea corals facing climate change, a transcriptome analysis NLK EGFR MAP3K7 SRC ARHA HEL114 NOTCH3 PMC9322955__F3 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts ATM CXCL10 MDM2 CDK4 ATR CDK6 PMC6628600__F5 UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression ANGPT4 GPR171 MTOR CP PMC9322955__F2 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts SMAD2 SMAD4 PMC4117527__F5 Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation UBE2D3 CSNK2A1 SMAD2 NRAS APOC1 SPRY1 TMEM158 PTEN RBBP6 FBXW7 TACC2 KHSRP GDF15 LDLR IL4 WDR5B AP1G1 PFKP ADM CHI3L1 HSPA4 CRY1 PLAUR KDM3A APC FPR2 LAMB3 PIGR TNF EPC1 GKAP1 CUL4B IGF1 RPS6KA1 KLF4 PMC9322955__F1 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts KEAP1 TNF PMC6199368__F5 Hypothetical model to sensitize GC BAD XPC XPA MCL1 PMC8185927__F1 Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGFB Signaling Pathways IGF1 SMAD2 CD34 ZAP70 GRB2 SMAD4 TPO IL6 PTEN PMC11277918__F2 cGAS-STING can transform a cold tumor into a hot tumor and promote tumor cell apoptosis IL10 CGAS IL6 TGFA IL1B PMC10815231__F5 Graphical summary of the mechanisms of action of microRNAs and lncRNAs in renal fibrosis TEC PFKM MTOR PMC20445__F6 Schematic diagram showing steps in the signaling pathway by which P LBP SRC PPY CFTR PMC8304747__F5 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration NMNAT1 NMNAT2 NMNAT3 FOXP3 PMC4359951__F3 Genomic analysis of metastatic cutaneous squamous cell carcinoma dik HGF BRAF EGFR MYC PTEN RB1 MTOR CDKN2A CDK6 NF1 ERBB4 ATM NF2 NOTCH1 CCND1 CDK4 NOTCH2 NOTCH4 KIT TP63 FGFR3 NFKBIA CARD11 CREBBP EP300 CDKN2B STK11 ATR RASAL3 PMC8304747__F2 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration ACLY ASS1 HEL-S-133P ASL FASN GLS PMC8730355__F1 Contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies CGAS CXCL1 CCR2 PMC10385272__F5 Key gene expression patterns in carbohydrate metabolism and lipid metabolism pathways in the pulp and seeds of Symplocos paniculate FH OGDH LPA ACLY PMC6857099__F4 BRD4 is involved in the transforming growth factor B (TGF-ß)/SMAD signaling pathway SMAD2 SMAD4 BRD4 PMC10815231__F2 Therapeutic implications of miRNAs and lncRNAs in AKI NLRP3 RIPK1 RUNX1 GOLPH3 CCL2 HIPK1 NR1C1 HK2 PMC10815231__F4 Graphical summary of the mechanisms of action of miRNAs and lncRNAs in DKD ROCK2 EGR1 NOX4 EDEM3 LIN28A MTOR RAB3B ACR FIS1 STAT3 PMC10815231__F3 Action of ncRNAs in CKD TSC1 NFAT5 MTOR PMC6370815__F7 KEGG cell cycle pathway analysis ME1 E2F4 MALL SMAD2 SMAD4 STAG1 ORC3 CDK7 ORC2 CDC6 SMC3 CDK2 RAD21 PCNA SKP2 MYT1 PMC7427467__F5 IL-27 tips the balance of immunity toward L IL10 CCL2 TNF IFNG PMC7504502__F3 Feedback loop on BMP4 pathway mediated by miR-125a/b and miR-23a-24-27a during both the exit of mESCs from naïve state and their neuroectodermal differentiation SMAD1 DKFZp781O1323 BMP4 PMC3628288__F2 Diagram of two potential molecular pathways of serrated neoplasia BRAF PMC26984__F1 Proposed pathway of EGF-induced cell proliferation of ER− breast cancer cells EGF PI3 EGFR CDK4 CDK6 PMC9608775__F1 MicroRNA-383: A tumor suppressor miRNA in human cancer CENPF RBM3 CASP2 PRDX3 HMGA2 ROBO3 CIP2A SOX11 ZEB2 PARP2 CCND1 TIPRL TRIM27 IRF-1 PMC9189572__F11 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription TFEB MAX ATF4 OPTN JUN PMC6593428__F7 Model describing the mechanism regarding the inhibitory effect of IFITM2 on Type I IFN signaling pathway TBK1 IFITM2 IRF3 PMC9189572__F10 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription CASP12 ATP6 ATF4 SVIP SKP1 RBX1 WFS1 TRAF2 PMC8786807__F7 Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell NR3C1 FKBP4 PMC6561916__F4 Stem cell-related signaling pathways in miR-25 overexpressing LX-2 cells CTBP2 CSNK1D PRKCZ MAPK9 CSNK2A1 GSK3B MYC SMAD4 CCNE1 FGFR1 NOTCH1 SNW1 SMO FURIN CDH2 PRKCI TUBB FOSL1 PSEN2 HEL-S-68p ADAR WNT3 AXIN1 PPP2R5C NR1C2 PPP2CA OTX2 CXCL12 PRKCH CDC42 PRKCE BTRC MAML3 CTBP1 LFNG RAB23 GAS1 DLL3 CCND3 COL1A1 CSNK1G1 NOTCH3 ADAM17 CCND2 DTX3L MAML2 LDLR CSNK1G2 JUN NCOR2 MAML1 KAT2B RBPJ DTX2 CD44 DTX3 ARHA RAC1 HDAC1 DVL3 NLK CREBBP hCG_2014051 PPP2R5E FRAT1 PSENEN MME PMC4351630__F6 Schematic summary of the effects mediated by RA-NPs against MPTP-induced injury in the dopaminergic (DA) nigrostriatal pathway of adult and old mice TH PITX3 PMC9317521__F3 New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC7723503__F8 Signaling pathway of CaOx-induced ferroptosis in HK-2 cells and rat renal tissues GPX4 FACL4 SLC7A11 SLC3A2 TF PMC8764312__F1 Novel Targets and Therapeutic Strategies to Protect Against Hepatic Ischemia Reperfusion Injury NLRP3 FYN TLR4 GSK3B IL6 MYD88 PMC6521546__F5 Superimposing mTOR signaling subgraphs from KEGG and WikiPathways TTI1 RICTOR CHUK EIF4E EIF4EBP1 MTOR DEPTOR RPTOR EIF4E1B MAPKAP1 MLST8 PMC3361581__F1 Depiction of arachidonic acid signaling pathway highlighting genes measured in this study PTGER2 PTGIR PTGFR PTGER1 PTGS2 ALOX15 ALOX12 PTGER4 ALOX5 PTGER3 PTGS1 PTGDR PMC6701280__F7 IH protection against liver fibrosis MMP2 SMAD4 PMC9015122__F2 Interaction types that are not found in SULT1A1 SULT2A1 BST2 PMC5410960__F4 Rb1 pathway CDK4 RB1 CDKN2A PMC7821926__F1 Unfolded protein response (UPR) pathway ATF4 EIF2A BCL2 XBP1 PMC8066821__F2 Biosynthetic (transsulfuration) and catabolic (oxidation) pathways of H2S SQOR PSAT1 HEL-S-64p PSPH PHGDH PMC8225085__F4 Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2 SFN KRT19 EGFR MYC CCND2 CCNE1 RARB MMP2 CST6 ABCG2 TFF3 ABCB1 JUN GATA3 MMP9 NR3C1 ADAM23 KRT18 ID1 HEL-S-130P BRCA1 RASSF1 BRCA2 CDK2 CHAD BCL2 CSF1 PYCARD HIC1 PMC6074780__F1 PD-1 in T-cell activation, exhaustion and effector function.Notes: (A) T-cells are activated via (1) binding of MHC plus peptide on an APC to the TCR and then (2) binding of APC CD80/86 to T-cell CD28 APC CD80 PMC3173057__F11 Schematic view of the proposed HSP60-TLR4 signaling in response to myocardial ischemia TLR4 IRAK1 MYD88 FADD PMC2913069__F1 Interconnected pathways that cause bone marrow failure TERF2 FANCD2 RPS7 RPL35A RPS26 RPS24 PINX1 TERF2IP RPL11 ATM RAD51 DKC1 NHP2 GAR1 TPP1 NOP10 RPS10 RPS17 FANCM FANCL FANCA ATR RPL5 FANCB TERF1 FANCE FANCG TERT FANCF PMC4291754__F4 Cell signaling pathways are allosterically elicited by the activated receptor tyrosine kinase (RTK) MDM2 GRB2 FOXO1 PMC7901191__F9 Wnt signaling pathway associated with FZDs ROCK2 ZNRF3 BAMBI INVS RNF43 APC NOTUM SOST LRP5 CER1 SMAD4 LRP6 SKP1 RYK ARHA GPR49 RBX1 LGR6 NLK DAAM1 SIAH1 PMC2583931__F1 Migrating D-loop model of recombination SPO11 FBXO18 RAD50 RAD52 RAD51 MSH4 MRE11A MSH5 PMC10814950__F8 Key signalling pathways targeted by a combination of PI3Ki (PIK-75) and CDKi (dinaciclib) CDK2 CDK4 CDC2 RB1 MTOR PMC6347506__F6 Integrative regulation of physiology by histone deacetylase 3 TBL1XR1 AMPD3 HDAC3 TBL1X BCAT2 GPS2 TF IFNG PMC4504805__F1 Schematic of BH4 de novo synthesis, salvage, and regeneration pathways and its role in 5-HT synthesis DHFR TPH2 AKR1B1 PMC6347506__F5 Integrative regulation of physiology by histone deacetylase 3 TBL1XR1 HDAC3 PC TBL1X FOXO3A TBR1 GPS2 TF STAT3 PMC4029488__F2 HFPN model of extended center metabolism pathway in E PTS POLE PGP GIP HPR PMC7723674__F8 Mechanism of action of nimbolide in diethylnitrosamine and N-nitrosomorpholine induced hepatocellular carcinoma mice CCND1 CDK4 IL1B PCNA PMC4029488__F1 Basic regulation mechanisms required in the process of a cell utilizing glucose and glycogen PTS POLE HP CRP HPR PMC6347506__F2 Integrative regulation of physiology by histone deacetylase 3 TBL1XR1 HDAC3 TBL1X EBP GPS2 PROX1 TF PMC3791603__F1 Hh signaling in animals DISP1 SUFU SMO SKI PMC6347506__F4 Integrative regulation of physiology by histone deacetylase 3 HEL-S-62p TBL1XR1 HDAC3 TBL1X ZBTB7B GPS2 SHF TGFB1 TF PMC7438472__F2 Activation of the AIM2 inflammasome CGAS AIM2 IL1B IRF-1 GSDMD PMC11946830__F2 Hijacking cellular pathways and oncogenic mechanisms in Cryptosporidium infections: Cryptosporidium manipulates several key host cell signaling pathways to ensure its survival and potentially contribute to cancer development TLR4 APC GPT RELA IQGAP1 CDC42 PMC5282877__F2 Signaling involved in CSCs that mediates melanoma progression NUMB CITED1 IGF1R BRAF NRAS MYC NOTCH1 ARHA SMO HIF1A IGFBP5 PMC9350720__F1 Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review HEL-S-62p CS C4B_2 MASP2 PMC8276946__F2 Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies FADD BAX PMC4054791__F1 Schematic representation of the photorespiratory pathway (in black) and the three circumvent pathways designed to overcome the photorespiratory losses HEL-S-62p PMC7360684__F2 Canonical TGFB signaling pathway and TGFB signaling targeting therapies SMAD2 MYC SMAD6 SMAD4 PMC3708179__F8 Enrichment of hyper- and hypophosphorylated peptides in the ERK/MAPK signaling pathway in the phosphoproteome of murine liver on treatment with high-fat versus low-fat diet BAD FYN MOS NFATC1 MYC GRB2 SRC EIF4E CRK PMC4678324__F3 Cell-intrinsic versus cell-extrinsic control of metastatic progression by miRNAs HMGA2 IGF1R DNAJA4 IGF1 PITPNC1 IGFBP2 RAF1 MERTK APOE BACH1 PMC4783254__F2 Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease HEL-S-102 GPX4 TF PMC2896712__F2 Metabolic pathway map constructed using the E-Cell RBC model MGP PGP PMC2744640__F4 Regulation of Mitochondrial Respiratory Chain Biogenesis by Estrogens/Estrogen Receptors and Physiological, Pathological and Pharmacological Implications NRF1 MTIF2 PGC SP1 TFAM PMC11087094__F3 Four most related metabolic pathways in digestive system tumors GOT1L1 PC OTC ARG1 ASS1 ASL HEL-S-5 GLS PMC8397173__F8 Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1 ATF1 PRF1 TF PMC5391460__F9 NEAT1 exerts antihantaviral effects by acting as positive feedback for RIG-I signaling IRF7 SFPQ TRAF3 MAVS PMC3242749__F4 Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice ATF4 BCL2 HTRA2 BAX PMC3140140__F1 Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways APC GSK3B LRP5 LRP6 PMC4312948__F7 Role of TRP channels in the vascular system TRPC7 TRPC1 TRPV4 HEL-S-11 TRPC6 TRPC3 TRPM2 TRPA1 TRPM7 TRPV1 PMC7503523__F2 Polyomavirus JC: one virus, two stories PML IGF1R IGF1 ATM NF2 APC MDC1 MYC MDM2 RAD51 ATR IRS1 PMC8969174__F1 Genetic architecture of childhood BMI exhibits dynamic changes over early childhood HHIP NR5A2 EHBP1L1 CAST GCK SCGB1A1 DLG4 NR2A2 GPSM1 SH3GL3 UBE2CBP EFCAB8 NPY SEC16B AgRP RIN2 PLCE1 LEPR PYY NCOR2 SH2B3 OPRM1 KLF14 CCNL1 GLP1R LEP MLXIPL MC4R PTCH1 PCSK1 FAIM2 PMC9235413__F5 Site of action of the Wnt signaling pathway inhibitors that are in current or were in past clinical trials APC GSK3B LRP5 PORCN PMC9235413__F3 Crosstalk between Wnt and other major signaling pathways in uterine fibrosis NUMB IGF1 LRP5 CCND1 LRP6 MTOR PMC9235413__F2 Wnt signaling in mechanotransduction and extracellular matrix (ECM) alterations in uterine fibrosis APC GSK3B LRP5 LRP6 PMC9235413__F1 Canonical and noncanonical Wnt signaling pathways ATF2 APC GSK3B LRP5 LRP6 RYK ROR2 RHO JUN CDC42 PMC7349809__F1 Mechanisms for respiratory syncytial virus (RSV) inhibition of type I interferon (IFN) production TBK1 TANK STAT2 IRF7 IRF9 TRAF3 RIGI IRF3 IFNAR2 IFNAR1 STAT1 TYK2 JAK1 MAVS PMC6275424__F1 Ras/ERK signal transduction pathway with emphasis on p120-RasGAP interactions TCF3 BRAF PPP3CA KRIT1 RASA2 GRB2 SHE RHO HAND2 PMC2667382__F8 Phosphorylation of the Translation Initiation Factor eIF2A Increases BACE1 Levels and Promotes Amyloidogenesis BACE1 ELF2 EIF2A PMC8898246__F2 Where are we in 2021 with heart failure with reduced ejection fraction?—current outlook and expectations from new promising clinical trials CORIN NPPB PGC FURIN PMC2976339__F5 Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity CASP3 HLA-E IMPACT ZAP70 SHE SYK LAT HLA-B HLA-C PMC8402548__F1 Analysis of Host Immunological Response of Adenovirus-Based COVID-19 Vaccines IL10 TH IL6 APC2 PMC8089370__F1 Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment SLC7A5 LLGL2 YAP1 ATF4 SLC3A2 TUB YBX3 YKT6 PMC11087094__F4 Three greatly important metabolic pathways in digestive system tumors PIG59 CS PC HSD11B2 PGP AGXT HSD17B2 CYP11B2 PMC11762646__F6 microRNAs regulate pathways by targeting multiple genes IGF1 CPT1A SMAD2 PTEN ABCA1 SP1 IGFBP5 IRS1 CYP7A1 PMC5767248__F3 AMPAR trafficking during Alzheimer’s disease (AD): early and later phases FYN GSK3B SMS PMC8481958__F1 Immunometabolism during inflammaging NLRP3 MTOR IL1B GDF3 PMC4608483__F2 RNR regulation in S PMC6755339__F2 Main synthesis pathway of n-3 long-chain PUFA-derived lipid mediators GPR32 FPR2 GPR37 PMC8837022__F3 Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death ELF2 CASP12 UBA2 ATP6 ATF4 SVIP BCL2 SKP1 RBX1 WFS1 TRAF2 SELL PMC3080176__F2 Diagrammatic representation of the top three canonical signaling pathways, proposed by the Ingenuity Pathways Analysis program, associated with differentially expressed genes in the microarray dataset POLE ATM TTN PMC5372523__F1 Nerve growth factor (NGF) and its Tyrosine Kinase A receptor (TRKA) are involved in several signaling pathways in epithelial ovarian cancer (EOC) COX2 NGF ADAM17 PMC7990367__F3 Pathways regulating cellular senescence and the SASP STAT1 CGAS IL1A ATM TRAF3IP2 MTOR ATR SIRT1 GATA4 STAT3 PMC11642960__F4 Pathway and network analysis of the proteins identified in the AR/SRF interactome HEL-S-89n NR3C1 CDC37 HEL-S-162eP HEL-S-49 HEL-S-125m AHR PELP1 FOXA1 ERBB2 CDK4 FKBP4 TERT PMC7963155__F4A MicroRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer PTEN PMC11642960__F6 Proposed common pathways of the SRF/AR interactome and the key proteins identified by APMS and bioinformatics TUBB4B PELP1 RAN TUBB4A PMC4860161__F1 Autophagy pathway ULK1 ATG12 MTOR DKFZp686F0183 PMC4018747__F4 Pathways leading from ssDNA-bound RPA to the recruitment of an error-prone polymerase η, ι, K or Rev1 for bypass of a potential template lesion REV1 POLK ATRIP POLN ATR RAD18 PCNA POLI PMC9147761__F1 Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application JDP2 EPCAM BMI1 IL6 PMC2721253__F2 Modes of neurite growth inhibition of molecules expressed on CNS myelin and oligodendrocytes LMO4 BMP2 RHO LINGO1 BMP4 PMC107042__F1 Diagram showing the relationships among the regulatory factors governing srf transcription initiation COMP PMC6563036__F3 Proposed mechanism between mTOR Signaling Pathway, Inhibitors and Photodynamic Therapy (PDT) TSC2 RICTOR TSC1 PTEN DEPTOR MLST8 PMC6563036__F2 mTOR Signaling pathway TSC2 RICTOR TSC1 PTEN DEPTOR MLST8 PMC5860060__F4 Association network of linc-RPIA identified in co-module 1 HLA-E NUMB VASP EGFR SMAD4 EZR RDX RANBP9 NRP2 RPTOR BCR AP2M1 SRC NCOA1 NCOR2 TRIO HEL70 SOS2 NRCAM EVL ROBO2 SPTB NR1C1 CREBBP EP300 SRGAP1 RGMA RPS6KA2 AGRN PMC2822437__F1 Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent Phenotypes TNF FADD BAX PMC4744573__F1 Standing your Ground to Exoribonucleases: Function of Flavivirus Long Non-coding RNAs DCP2 DIS3L2 XRN1 PMC8041604__F4 Mechanisms of PI3K/Akt/mTOR pathway and MAPK pathway, and inhibitors in ovarian cancer clinical development TIAM1 BAD RIN1 MDM2 PTEN RAC1 MTOR OTP CDC42 PMC10538272__F5 Irreversible repolarization of tumour‐associated macrophages by low‐Pi stress inhibits the progression of hepatocellular carcinoma COX2 CCR7 CCL17 MYD88 TNF PMC11959054__F7 Role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout STAT1 SOCS3 MYD88 SOCS1 STAT3 PMC8699560__F1 Enhancing Therapeutic Approaches for Melanoma Patients Targeting Epigenetic Modifiers PTEN CTLA4 TNF PMC2865177__F1 ER stress-induced apoptotic pathways ATF4 EIF2A BCL2 ERO1A TRAF2 BAX PMC8541136__F1 Heparanase Regulatory Network in Health and Disease EGR1 TLR4 FGF23 HGF BRAF SP1 HPSE IL1B SP3 PMC6721072__F5 Ca2+ toolkit in endothelial colony forming cells (ECFC) PLCB2 TRPC1 TRPV4 IGF2 TRPC3 ORAI1 STIM1 TRPV1 PMC7516134__F1 Zoledronic acid on the bone metastatic niche and the “vicious cycle of bone metastases” CXCR4 IL6 CXCL12 IL6R IL1B PMC6721072__F2 Ca2+-dependent activation of the extracellular signal-regulated kinase (ERK) pathway and of the Nuclear Factor of Activated T-cells (NFAT) PLCG1 TRPC4 TRPC3 ORAI1 INSR PMC8391121__F1 Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases EGF RAC3 EGFR SRC NCK1 VAV2 PMC6721072__F1 Pro-angiogenic Ca2+ toolkit in vascular endothelial cells PLCB4 PLCG1 PLCB2 PLCB3 TRPC4 TRPC1 TRPC6 TRPC3 ORAI1 STIM1 PLCB1 INSR PMC8262160__F6 Knockdown of GPSM1 Inhibits the Proliferation and Promotes the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway GPSM1 ADCY6 PMC12207805__F8 Proposed mechanism by which L-Phe promotes liver steatosis BNIP3 MTOR NR1C1 PMC7664917__F2 Signaling pathways in ferroptosis GPX4 FACL4 SLC7A11 SLC3A2 GLS PMC2854301__F9 The Transcriptional Repressor REST/NRSF modulates Hedgehog Signaling SHH REST PMC6801086__F8 Base excision repair pathway, homologous recombination pathway, and how BER intermediates may lead to HR POLE POLK BRCA2 RAD51 POLN PNKP BRCA1 PMC3656715__F1 Hippocampal BDNF/TrkB signaling pathways that modulate depressive behavior and antidepressant responses GRB2 ARHA MTOR BDNF CDC42 PMC7306092__F3 Progression of fibrosis caused by expression of ECM proteins after activation of TSP-1 CD47 SMAD4 RHO CD36 PMC8186467__F2 Bidirectional Relationship Between Cancer Epigenetics and Metabolism BCAT1 SLC7A11 SLC3A2 EZH2 ARID1A TET2 BAP1 PMC7306092__F2 Activation of pathways triggered by hyperglycemia to induce TSP-1 expression EGR1 SP1 PMC7276297__F1 Biochemical pathway of steroidogenesis DHCR7 CYP11A1 CYP17A1 CYP21A2 STAR CYP11B2 PMC7465134__F1 miRNA modulators of the p53 signaling pathway in Adrenocortical Carcinoma CASP3 CCNB2 MDM2 CASP9 BAX PMC10177463__F3 BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge NF1 EDN1 HGF EIF3A PTEN PPP2R1B MTOR PMC5215973__F2 Deubiquitinases in breast cancer USP15 USP2 POLK SMAD2 APC GSK3B SMAD4 GADD45A DDB2 USP25 ATG10 USP48 CYLD RELA USP9X MDM2 BAX PMC7465134__F3 miRNA modulators of the Wnt/Beta-catenin signaling pathway in Adrenocortical Carcinoma LRP5 LRP6 TF PMC7465134__F2 miRNA modulators of the mTOR signaling pathway in Adrenocortical Carcinoma EGFR LRP5 LRP6 EIF4E TNF MTOR PMC9524263__F4 Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage SIRT1 STAT3 PMC8044947__F1 Popular signaling pathway in the research of primary mediastinal large B-cell lymphoma PTPN1 B2M SOCS1 PMC8033456__F1 STING and transplantation: can targeting this pathway improve outcomes? TBK1 CGAS CD47 APC IRF3 CTLA4 PMC6721734__F6 Molecular interplay between estrogen, EGF, and Notch signaling pathways in FTEC ciliogenesis EGF EGFR FOXJ1 PMC8924130__F4 Glioma: molecular signature and crossroads with tumor microenvironment NF1 HEL-S-26 CCR2 YAP1 EGFR CDK4 PTEN CCL2 RB1 TNF MTOR CDK6 PMC8924130__F3 Glioma: molecular signature and crossroads with tumor microenvironment EGFR TNF HIF1A MTOR PMC3937510__F2 Canonical Wnt signaling () APC LRP5 LRP6 DKK1 FRZB PMC7824196__F2 Autophagy regulation by the mTOR signaling pathway ULK1 MTOR TRPM7 SIRT1 PMC7824196__F1 Different steps of autophagy ULK1 ATG12 ATG3 ATG101 MTOR DKFZp686F0183 NBR1 PMC2819754__F2 Transcriptional regulation of the differentiation of Th2 cells APC IL4 GATA3 PMC2819754__F1 Transcriptional regulation of the differentiation of Th1 cells STAT1 FOS APC STAT4 TYK2 IFNG PMC6257326__F2 Network view of associated proteins created within Ingenuity Pathway Analysis software for visualizing molecular interrelationships SCAP2 IKBKG MAPK8 ATP1B1 GFAP TNF GLRX STAT1 ISG15 PRMT1 KYNU GRB2 APP HEL-75 BDKRB2 PHB2 PSMB8 HEL-S-81p PMC8156203__F3 Targeting Reactive Oxygen Species Metabolism to Induce Myeloma Cell Death PSAT1 ENO2 PSPH EN2 HEL-S-133P PHGDH HK2 GLS PMC7552066__F4 JAK/STAT signalling pathway STAT1 STAT2 IRF9 STAT4 EGFR TYK2 JAK3 JAK1 STAT3 PMC7552066__F6 HPV modulation of the STAT3 signalling pathway EGFR TYK2 JAK3 RAC1 JAK1 STAT3 PMC5882332__F3 Signaling lymphocytic activation molecules Slam and cancers: friends or foes? EGF PLK1 MTOR PMC7509487__F2 How a miRNA affects cellular function: Left, repression of one critical mRNA by an individual miRNA determines cell function DUSP5 PTEN SOCS1 PTPN22 PMC3401939__F1 Targeting of oncogenes and miRNAs by retroviruses MYB PIM1 MOS FOS LCK MYC SRC PMC7830227__F2 Targeting the Hippo signaling pathway LATS1 CDK9 BRD4 PMC213796__F7 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer EZH2 SUZ12 EED PMC2386416__F1 Illustrations of the 5 Alpha-reductase action and the pathway of androgen action on target gene expression EGF IGF1 TGFA PMC7830227__F1 Hippo signaling pathway in mammalian cells AJUBA LATS1 PMC7177258__F5 JNK signaling in the stem cell niche HMGB1 TNC opn PMC7177258__F1 Regulatory system of the C-JUN N-terminal kinase (JNK) signaling cascade MINK1 FOS SMAD2 ATF2 JUND CRKL PMC8909726__F6 Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma MMP9 EIF4E HNRNPF USP1 PMC7177258__F3 JNK signaling in normal stem cells WNT3A SMAD2 ATF2 GPR49 AXIN2 TF PMC8807551__F7 FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway EGFR MTOR BAX PMC7073129__F2 Schematic demonstration of the inhibition of the RAR pathway by BMS LRP5 WNT2B PMC7073129__F1 Interactions between retinoid signaling and the Wnt/Beta-catenin pathway on the cellular level for growth plate chondrocytes during endochondral ossification RUNX2 LRP5 COL2A1 COL10A1 SOX9 PMC7430027__F7 KEGG pathway classification map of the experimental group CD47 BAD NPNT CD44 PTEN RAC1 TNF MTOR RXRA TSC2 HEL-S-11 VTN MDM2 GRB2 VWF CHAD BCL2 SYK RBL2 CD19 CD36 PMC7230796__F1 Metabolic pathway of vitamin D (based on Jenkinson 2019 and on Feldman et al CYP27A1 NR1i1 CYP2R1 DHCR7 CYP3A4 CYP24A1 CYP27B1 PMC6290262__F1 UPR activation ATF4 XBP1 PMC5819363__F1 Genomic Landscape of Pheochromocytoma and Paraganglioma MYC VHL RHEB MDH2 TMEM127 TSC2 NF1 RET TSC1 MAX NGFR FH SMO CSDE1 PMC10920911__F4 Lipid metabolic reprogramming on CRC NLRP3 CPT1A AGPAT4 LPA IL1B STAT3 PMC9407613__F2 New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies SMURF2 FURIN SP1 HEL-S-69p PMC10920911__F3 Glucose metabolic reprogramming on CRC TXNIP HEL-S-133P STAT3 PMC3236061__F5 Cooperation of the genes in the DNA repair cluster MPO TDG BLM NTHL1 POLG CDKN2A DBF4 RBBP8 PMS1 SMC1A MNAT1 FAU ATM APEX1 NF2 MSH6 RAD50 REV3L RAD51 MSH2 GMNN XRCC3 RAD1 SET RPA1 HEL-S-71 GTF2H4 APC BRCC3 PARP1 UBE2B BRCA1 BCL6 RFC1 MCM3 RAD54B MCM2 CDC6 RAD17 BRCA2 UBE2V2 ARC VCP RAN ATR CYCS TERT PMC6305530__F1 Hepatitis C virus-induced inflammation NLRP3 TLR8 IL16 TLR7 TLR4 MYD88 TLR3 PMC11608335__F1 Using Z. mobilis as the chassis for biochemical production EFS HEL-S-62p PDC XDH IPP PMC9394702__F3 miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma PMC7239885__F3 Calcium signalling pathway enriched by 48 downregulated genes encoding 23 proteins marked by stars PLN BCR CAV3 HRC MCU CAV2 TRDN CP PMC7397015__F1 Summary of experimental approaches used in identification of major mTOR signaling components RAB35 TSC2 RICTOR FLCN SLC38A9 FNIP2 TBC1D7 MTOR DEPTOR RHEB PMC10473100__F1 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities TRADD STAT2 RIPK3 MIP MYD88 TNF TRPM7 TLR3 STAT1 RIPK1 TLR4 CASP8 FADD MLKL PMC9158378__F1 Sonic hedgehog signaling pathway is susceptible to both genetic and environmental dysregulation BOC CDON DISP1 PTCH1 SHH SMO GAS1 PMC6872739__F7 Differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation CD163 RAC1 MERTK CR1 IL1B PMC10473100__F3 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities ABO RIPK3 TNF MLKL PMC7909827__F3 Paracrine interaction between Beta-cells and D-cells CUL4B SST UCN3 HEL-S-11 INS RYR3 DDB1 GAA HHEX PMC7909827__F2 Nutrient-secretion coupling in D-cells SST RYR3 GAL PMC6668790__F6 Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo SLIRP MTPAP POLRMT PMC4555078__F1 RTK signaling pathways and representative regulatory microRNAs EGR1 FOS EGFR CDK4 PTEN MTOR JUN CDK6 PMC6393639__F6 Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer CDK4 CCND3 CDK6 PMC2949191__F6 Scheme outlining the novel role of Nogo-A in controlling neuronal survival in the ischemic brain ROCK2 ARHA PTEN PMC6813780__F2 Genomics of Apicomplexan Parasites HEL113 GAL PMC4833551__F1 Pathways involved in physiological and in pathological cardiac hypertrophy actuated in calcific aortic valve disease (CAVD) IGF1 FGF2 MTOR PMC7730145__F3 Novel strategy to facilitate neuronal Cl− extrusion and EGABA by coincident NKCC1 inhibition and KCC2 activation by inhibiting the WNK-SPAK/OSR1 kinases WNK3 WNK1 OSR1 HEL-S-29 PMC7552066__F7 HPV modulation of the STAT5 signalling pathway IL3RA EPO EGFR TYK2 JAK3 KLF13 PDZRN3 JAK1 FBXW7 PMC8795890__F3 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration IL18 DLL4 MSC NOTCH1 DKK1 MTOR SOX9 PMC9604206__F2 Molecular Targets in Osteosarcoma Treatment EGFR JAG2 ADAM10 PMC8795890__F2 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration MMP3 NLRP3 BAD IL16 PTEN SOX9 BACH1 BAX PMC9371363__F2 Negative and positive regulators of IL-4 and IL-13 signaling: PARP14 SOCS3 IL13RA1 TRAF6 PARP1 IL17RC IRS1 TYK2 JAK3 JAK1 ARG1 SOCS1 STAT3 PMC9371363__F1 Canonical and non-canonical IL-4 and IL-13 signaling pathways: PI3 IL13RA2 SRC TYK2 JAK3 JAK1 IRS1 STAT3 PMC5161243__F7 Downregulation of a GPCR by Beta-Arrestin2-mediated Switch from an Endosomal to a TGN Recycling Pathway GIPR GIP PMC7432778__F6 IL-17A has two receptor complexes, IL-17RA/IL-17RC and IL-17RA/IL-17RD, in keratinocytes FLG TRAF6 IVL IL17RC PMC5833450__F6 Melatonin-induced signaling pathway PC BCL2 RAC1 NCF1 DKFZp686F0183 GAA BAX PMC7674767__F1 Extrinsic and intrinsic pathways to apoptosis BAD APAF1 BIK BMF HRK BAX BOK PMC7790578__F9 KEGG pathway details identified by FB against COPD WEE1 ATM LYN ATR FADD ELL BAX PMC5735114__F2 Distribution of differentially expressed genes in astrocytes following hypoxia+ hypothermia vs ROCK2 BAMBI INVS APC SOST NOTUM GSK3B CER1 RAB23 SKP1 ARHA GAS1 NLK SUFU SMO ZIC2 PMC6599034__F2 Label propagation defines signaling networks associated with recurrently mutated cancer genes PLK1 FOXM1 MYC BARD1 POLL MTOR GAA APLF ATM SPEN CDH2 ATR POLM CP STAR TERT PMC8131521__F2 C9ORF72: What It Is, What It Does, and Why It Matters CGAS ULK1 RAB8A TFEB WDR41 SMCR8 ATG101 PMC8776063__F13 Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells AVP HEL-S-15 AQP2 AURKA SSH1 PMC7014170__F5 Schematic model illustrating the signaling pathway by which ANG reduces the inflammatory responses involving Myd88 and the nuclear translocation of NFKB in LPS induced EIU TLR4 MYD88 IL4 IL1B PMC12179876__F1 Action and potential therapeutic targets of TGF-Beta-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension SMAD2 SMAD4 ARHA PMC6298946__F1 IL-20 receptor cytokines and their receptors IL22RA1 IL20RB IL24 PMC8718573__F3 Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers MUC1 AFP KIT ANXA1 CALCA CD33 EGFR EFNB2 MTOR MAGI3 GAST LEP PLAT IER3 AGER ANGPT4 ERBB2 TRPC6 ENO2 CCND1 WFDC2 B2M LTK PCNA PMC2553363__F2 ER stress pathway ATF4 EIF2A TRAF2 XBP1 PMC2553363__F1 Extrinsic and intrinsic pathways of hepatocyte apoptosis BAD BAX PMC9197809__F1 Research progress on drugs targeting the TGFB signaling pathway in fibrotic diseases TGFBR1 GRB2 RHO TRAF4 CDC42 PMC5297047__F6 The G-protein, cAMP/PKA signaling alterations found in the ZMEL-R1 cells GRK4 RAP1A SRC ADRBK1 STAT3 PMC6598629__F1 The supraspinal locomotor network TH PC PMC9322890__F14 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) CASP3 EGF APAF1 EGFR CASP9 ARHA PTEN MTOR BAX PMC4747023__F3 Unique genetic and epigenetic mechanisms driving signatures of paediatric diffuse high-grade glioma CORT IGF1R FGFR1 BRAF PDGFRA PIK3CA PTEN PMC4090903__F2 TLR4 intracellular signaling cascade CD14 TLR4 IRAK1 CXCL10 IRAK4 MYD88 TIRAP PMC9387879__F1 Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries HMGB1 STAT3 PMC6152442__F1 SRSF1 regulates SUMO conjugation to different spliceosomal proteins PRPF3 PUF60 DHX15 SNRPA SF3A2 SF3A1 PRPF31 U2AF1 CHERP WDR57 SMO SF3B6 U2SURP SNRPA1 PRPF8 PRPF4 SNRNP200 RBM17 DKFZp434N041 PHF5A PRPF6 DDX46 CD2BP2 U2AF2 SNRPB2 PMC5010983__F1 The (A) Wnt/Beta-catenin, (B) AKT/mTOR, (C) ERK/MAPK signaling networks that are important for oligodendrocyte development and myelination TSC2 RICTOR APC GSK3B LRP5 LRP6 PTEN MTOR IRS1 PMC9322890__F11 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) NLRP3 TLR9 KEAP1 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 IL1B PMC9322890__F10 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) EGF FOXA1 MTOR BAX PMC9658772__F2 E3 Ligases in Cervical Cancer and Endometrial Cancer FHL1 RNF43 SMAD2 EGFR SMAD4 PTEN MKRN1 RBBP6 NOD2 TRIM65 IER3 MDM2 SKP2 PMC6728366__F7 The PCP and Wnt pathways act in parallel to establish coordinated hair cell polarity and orientation in the neuromast GPC4 PMC9503233__F1 Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome NLRP3 CARD9 TLR4 SYK IRF3 RAF1 MYD88 PMC4992866__F11 Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation EIF5A PSAP RPS6 PMC3499531__F6 Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis) RAC3 MAP2 ING1 MAPK3 CST2 PMC10382028__F1 Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance HEL-S-30 CXCR4 CXCL12 HEL-S-87p MTOR PFKP JUN PCNA HEL-S-162eP PMC3470040__F1 MYCN-dependent apoptosis and the MDM2–p53 pathway HIPK2 MDM2 BMI1 HMGA1 PMC6040253__F1 Schematic model of the regulation of the Nrf2 signaling pathway MAF KEAP1 RBX1 NQO1 PMC3034442__F3 Glycine synthesis and degradation DLD GLDC AMT GCSH PMC2677061__F1 Postnatal Roles of GDNF Family Members in Nociceptors Plasticity RET NGF GDNF GFRA3 PMC6947889__F7 Induction of pyroptosis via ER stress and the effects of SIRT1 on this process ATF4 EIF2A SIRT1 PMC5979320__F2 BCAAs balance and its multiple roles via PI3K-AKT-mTOR signaling pathway TTI1 RICTOR MTOR DEPTOR IRS1 RHEB PMC11849169__F1 Pathway for triterpenoid saponin biosynthesis in S PDC IPP PMC11876490__F3 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape COPZ1 ATP6V0D1 H2AC20 RAB5B SND1 SNX27 AP3B1 VPS35 TUBB PAFAH1B1 RAB22A GNA13 UBA3 SRSF9 GFPT1 RAB10 DDX39B COPS4 H2AC14 HIST1H2AK H2AJ NAPG PAPSS1 ACTG1 IGF2R NCBP2 PEAK1 EEF1A1 PPP2R1A TLN1 EEF1E1 EEF1G EIF5 CSTF2 PPA2 USP9X ARL8B EIF4A3 RTCB H2AC19 PPP2R2A HIST1H2AH GARS1 TRNT1 ESRP1 YIPF6 PSPC1 TRAPPC5 H3-7 TJP1 IARS SH3GL1 RCC2 HEL-S-130P HDAC1 PS1TP5BP1 LIMS1 COPS6 ARF5 NARS1 INF2 RAN TARDBP PMC11849169__F5 Construction of a biosynthetic pathway for CK production in S ERG ENO1 IPP PMC4530213__F5 Functional connections brought by the active clusters between T2D and obesity EPOR PRKCZ CHUK HEL-S-1 EGFR MAPK3 SMAD4 CRKL INSR PRKCA FRS2 CNTFR UBE2I PTPN11 LEPR CSF2RA JUN FOS NTRK3 TCF7L2 IL6 PIK3R3 CBL PRLR GRB2 JAK3 TYK2 SOCS1 PMC8385664__F2 microRNAs, the Link Between Dengue Virus and the Host Genome TLR7 GSK3B IRF3 MYD88 PMC11876490__F4 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape DNPH1 LYZ RUNX2 GSK3B FTL ATP6V0D1 SORD RBX1 ATP2B1 TUBB2A HEL-S-162eP USO1 HINT1 AGA PEX5 SPTBN1 PSMB10 PCNA H2BC11 PMC7544989__F10 Ouabain effects in cultured human skeletal muscle cells ATP1A1 SRC STAT3 PMC4344548__F1 Sites of canonical Wnt signaling deregulation in PD WNT3 LRRK2 APC GSK3B LRP5 LRP6 PMC9598597__F3 Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties CD14 TLR4 TRAF6 MYD88 PMC12066262__F1 Pancreatic intestinal lung pathway in acute pancreatitis IL10 IL6 TNF PMC7053872__F5 Potential pathway of NAFLD development LPO CYP4A11 IL1B PMC5797541__F1 Representation of proteins and protein complexes involved in the “Autophagy – animal” KEGG pathway CTSL TSC2 TSC1 ATG3 PIR PTEN HIF1A HEL-S-130P HEL-S-69p PMC8990928__F1 Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers XDH TPMT NUDT15 PMC2604897__F2 Putative biochemical pathways involving MGAT3 UNK TCF12 CP PMC9698579__F3 Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics? TIMP3 CDH2 PMC3109034__F6 Working model for the role of the miR-29 family in TGFB2–mediated signaling PMC6321710__F9 Pathway visualization INS FOXO1 INSR CBL PMC5123939__F1 Two-signal model for NLRP3 inflammasome activation NLRP3 CASR NOD1 GPRC6A IRAK1 BRCC3 IL1B NOD2 FADD MAVS PMC5123939__F2 Activation for non-canonical and alternative NLRP3 inflammasomes NLRP3 RIPK1 TLR4 MYD88 FADD PMC9428607__F2 Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression? DRD5 DRD3 GSK3B GSK3A DRD1 DRD2 DRD4 PMC3949576__F2 Effective double whammy targets DNA synthesis in leukemia NDP TK1 PMC7457014__F5 Knockdown of DAP alters gene expression of the mTOR signaling pathway during proliferation of turkey satellite cells TSC2 ULK1 TSC1 ELF3 RHO EIF4E RPS6 MTOR EIF4B RHEB PMC1782267__F2 TGF–TAK1 pathway SMAD2 ATF2 SMAD4 PMC1782267__F1 TGFB1–Smad pathway SMAD2 SMAD6 SMAD4 PMC8317223__F2 Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook CYP2C19 CYP3A4 PMC7581990__F1 Metabolic reprogramming is involved in malignant transformation of prostatic cells HEL163 ACLY ACD FASN PMC5832558__F1 Urinary excretion of citric acid (TCA) cycle metabolites and the renal expression of genes that regulate these metabolites were significantly reduced among participants with versus without non-diabetic CKD SDHC CS IDH3B HEL60 HEL-S-32 HEL-S-26 FH OGDHL ACO2 SUCLG1 SUCLA2 OGDH SUCLG2 SDHD SDHA SDHB PMC8645640__F7 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway IL6 STAT3 PMC4089598__F2 Regulatory T cells and co-stimulatory pathways APC CTLA4 PMC7923240__F8 De Novo Transcriptome Assembly of Two Microsorum Fern Species Identifies Enzymes Required for Two Upstream Pathways of Phytoecdysteroids MVD DHCR7 EBP DHCR24 MVK IPP PMC9117991__F5 Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients CD44 HEL-S-133P PMC5240418__F1 The notch signalling pathway in prostate cancer NOTCH1 PMC8762210__F11 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer IGF1R ATP6V1G2 ATP6V1E2 ARHA PTEN ATP6V1C1 MTOR ATP6V1C2 IRS1 PDPK1 RPTOR RHEB ATP6V1E1 RICTOR GRB2 PIK3CA MAPK1 WNT10A ATP6V1A ATP6V1G3 SGK1 PMC8762210__F10 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer PDGFRA GSK3B CREB1 FGFR4 ENG PTEN GNG10 MX2 GNG12 ANGPT1 RS1 PPP2R2B GNB3 PDGFA PPP2R5C CASP9 JAK3 CHRM2 COMP NTRK2 AKT3 PMC6352191__F7 Proposed regulatory network involved in Keratinocytes of Type 2 Diabetes TH ISG15 BTK OAS2 OAS3 TLR7 TLR9 MX2 PRL CP MX1 PMC5926825__F1 Reactive Oxygen Species in Metabolic and Inflammatory Signaling TSC2 ATM HIF1A MTOR STIM1 PMC6352191__F6 Protein–protein interaction (PPI) network in cluster 1 from the MCODE sub-network analysis PLSCR1 DHX58 HERC6 EGFR POLR2F EIF2AK2 NOD2 IFITM1 MX2 USP18 MX1 UBC STAT1 ISG15 ELAVL1 SP110 OAS2 OAS3 XAF1 APP SRC SAMD9 OGDH IRF-1 ATG12 IRF9 BCL6 IFI44 BIRC2 PARP12 EPSTI1 ATN1 MAVS PMC7857696__F1 Natural and synthetic mucin-type O-glycosylation pathways HEL-S-62p C1GALT1 ST6GALNAC1 PMC7338805__F7 Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress MAF NRF1 PMC9138239__F1 Key Molecules of Fatty Acid Metabolism in Gastric Cancer CD34 GSK3B DEK ACLY MTOR CEBPB BOLL FASN PMC11591473__F6 Oxidative stress induced senescence pathway MAPKAPK2 MAP2K4 IFNB1 MAP2K3 MAP2K6 TXN SUZ12 EED MINK1 MDM2 MAPKAPK3 EZH2 JUN KDM6B PMC7381543__F2 Molecular and metabolic regulation of effector and memory T cell differentiation SOCS3 P2RX7 APC TET2 BCL6 STAT1 CXCR3 LEF1 GIG8 CD27 TNLG8A IL27 STAT4 CD40 KLRG1 CD80 STAT3 PMC11095605__F2 Activation and inhibition of the Wnt/Beta-catenin signaling pathway TMEM88 SFRP5 PMC5124731__F1 Production of aromatic compounds via shikimate pathway in microbes PDC PPY SMO PMC11591473__F4 Detoxification of reactive oxygen species pathway TXN2 GPX2 HEL-75 NOX4 HEL-S-44 CCS PMC9166526__F5 Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape SRC HIF1A AXL ZMYND8 CD24 PMC8165473__F2 Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing CXCL1 VCAM1 CCL2 TNF PMC9501315__F2 Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology KEAP1 VWF BCL2 MTOR PMC11015399__F1 Hippo signalling pathway and its impact on eye diseases NF2 RHO PMC5994134__F4 Reconstruction of metabolic pathway of Woesearchaeota in the central carbon (a) and comparison of genes relating to the ferredoxin-dependent pathways between organisms from oxic and anoxic biotopes (b) COPA NAPA CPA2 PMC10529747__F3 TGFB as A Master Regulator of Aging-Associated Tissue Fibrosis ATM SMAD2 SMAD4 NOX4 PMC6168472__F7 Proposed mechanistic model of KMT2D in prostate cancer LIF KLF4 OSM MLL2 PDPK1 PMC2854285__F2A mTOR and cancer: many loops in one pathway TSC2 TSC1 DEPTOR PMC4578605__F3 Depletion of Pkh affects glycogen metabolism PGM3 PGM2 PMC12154116__F10 KEGG pathway maps enriched with downregulated differentially expressed genes (DEGs) in THP-1 cells following treatment with Biochanin A (100 μM) MAU2 ESCO1 CDC14B SMAD4 WAPAL STAG1 CDK7 STAG2 CDC45 MTBP DDX11 SMC3 CDK2 MDM2 CYC1 NIPBL CDT1 KNL1 RAD21 PCNA TRIP13 SKP2 MYT1 TICRR PMC2861828__F1 Signaling pathway that connects store-operated Ca2+ entry with NFAT-dependent gene transcription in T cells ITK HEL-S-11 MCU ORAI1 LAT PMC8277837__F5 Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma ZFHX3 SLC7A11 TUBB6 SMAD2 ZNF460 CTGF INSR TUBA1C ACACB SLC39A14 ZNF331 TLR5 ANGPTL4 SETDB1 ZNF550 ZNF607 ZNF627 NR3C2 ZNF569 TCF7L2 ZNF324 ZNF565 ZNF763 ZNF443 ID3 ZIK1 ZNF461 ZNF37A TUBA1A ZNF614 KMT2A ZNF354B EP300 TUBB4B KLF4 MLYCD TUBA1B SMAD1 DKFZp781O1323 MLL2 PMC11876390__F1 Metabolic pathways of polyamines DAO ARG2 SRM EIF5A PAOX OTC DOHH DHPS SMS ASL PMC2984459__F1 Schematic overview of Toll-like receptor (TLR)4 signaling pathway STAT1 CD14 TLR4 LBP TRAF6 MYD88 PMC6417856__F10 The main findings are illustrated (A) ChAT RYR1 CHRNA1 SNAP25 CACNB1 PMC6481626__F1 Pathways that influence uracil accumulation in DNA TYMS UNG TK1 PMC4231421__F7 LPA-dependent platelet-induced tumor cell metastasis EGF PC LPA PMC6501144__F2 Angiogenesis signaling pathways induced by oxidative stress ATM TRAF6 MYD88 TLR3 PMC3016978__F6 Model for a meiotic gene regulatory cascade initiated by inactivation of a pathway that promotes turnover of meiotic transcripts produced in vegetatively growing cells FBP1 TRO MEI4 REC8 PMC9690211__F6 Transcriptome Analysis of Chinese Cabbage Provides Insights into the Basis of Understanding the Lignin Affected by Low Temperature HEL114 CAD PMC5762868__F1 Schematic diagram of the metabolic cycle of THF and the C1 metabolic pathway MTHFD1 HEL-S-51e MTHFD2 AMT MTHFD1L PMC7163125__F10 LXA4, a potential therapeutic agent against KSHV AHR MTOR SGK1 PMC7226428__F1 Growth hormone (GH) on the vascular endothelium GHB2 GHR GRB2 SHE SRC PMC3414427__F3 Schematic model showing the existence of distinct secretory pathways in pheochromocytoma TH PNMT NPY DBH CADPS SNAP25 PMC4613136__F2 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division SMUG1 TDG UNG TP53BP1 PMS1 XRCC5 MLH3 ATM APEX1 HUS1 RAD52 RAD51 MSH3 MSH2 H2AX XRCC3 RAD51B RAD51C RAD1 RAD51D XPC SSB PARP1 LIG1 RAD9A BRCA1 MPG PMS2 RAD9B RAD17 BRCA2 PARP2 TREX1 ERCC1 XPA ATR OGG1 PMC4613136__F1 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division SMUG1 TDG UNG TP53BP1 PMS1 XRCC5 MLH3 ATM HUS1 RAD52 RAD51 MSH3 MSH2 H2AX PRKDC XRCC3 RAD51C RAD1 RAD51D XPC SSB PARP1 LIG1 RAD9A BRCA1 MPG PMS2 RAD9B RAD17 BRCA2 ND2 PARP2 TREX1 ERCC1 XPA ATR OGG1 PMC3131053__F1 Differential involvement of IKKB/NFKB signaling in neurons of the hypothalamic arcuate nucleus in the pathogenesis of obesity and hypertension POMC NPY AgRP PMC4594510__F4 Schematic diagram for the signaling pathway involved in dexamethasone-induced TRPC4 channel activity TRPC4 RASD1 NACA2 PMC8221613__F1 General schematic of astrocyte reprogramming using TFs and miRNAs SOX2 ASCL1 PMC7641965__F3 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications CD47 CXCL10 EGFR MYC IL8RB CCL7 CCL5 CCL4 CXCL3 PTEN CCL1 STAT3 PMC7641965__F1 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications APC CD80 LAG3 ARG1 PMC5888911__F7 Schematic representation of the influence of high NT on FA anabolism and catabolism biosynthetic pathways PC LPA PMC8740421__F7 Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation AGO2 TLR4 NRP1 PMC3744802__F5 Model of regulation of the length of D-loop extension by PCNA and choice of polymerase POLK POLN PCNA PMC11048329__F3 Schematic presentation of current evidence on Cx32 association with signaling pathways regulating proliferative and cell death processes RIPK1 EGFR CCND1 RIPK3 SRC TNF MTOR HDAC1 MLKL PMC11048329__F2 Schematic presentation of current evidence on Cx32 association with EMT and the HCC chemotherapeutic resistance with oxaliplatin or doxorubicin PMC3594782__F1 Serotonergic transcriptional networks and potential importance to mental health SPR TPH2 PMC7609422__F1 Core proteins involved in the autophagy pathway and its regulation in zebrafish, knockout (KO) zebrafish lines highlighted in red, and boxes show commonly used drugs which can activate (green) or inhibit (red) autophagy activity ULK1 ATG12 ATG3 LAMP2 KIAA1632 DRAM1 AMBRA1 ATG101 MTOR OPTN DKFZp686F0183 SPNS1 PMC2196031__F8 Schematic presentation of the proposed sites of inhibition of the ceramide pathway by CrmA and Bcl-2 FADD PMC6607964__F6 Snapshot of trastuzumab resistance pathway ERBB2 HEL-S-281 PMC3030666__F2 Impact of Aging on Dendritic Cell Functions in humans IRF3 IL6 PTEN MYD88 PMC4682110__F5 Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas KDM5B IQGAP3 BRAF SFN ALK EGFR SMAD2 MYC SMAD4 RHPN2 MTOR CDKN2A CDK6 CHEK2 FLT1 SMARCA4 LRP1B MDM2 SRC CCND1 CDK4 TRIO CCNE2 APC RAC1 ITGB4 RAC3 CREBBP TSC1 ITGB8 MAP2K1 CDKN2B ERBB2 STK11 FSCN2 SETD2 CDC42 PMC11528492__F5 Bioinformatic reconstruction of the L CS HPD TRO PAH PMC7901941__F1 Characterizing oligodendrocytes throughout the lineage MOG PDGFRA MBP OLIG1 SOX10 PMC3715049__F1 Proteomic strategies for studying the mechanism of miRNA processing and miRNA-mediated translation repression SRM DROSHA SCX PMC5937267__F1 Finally, expression of T-cell co-stimulatory and co-inhibitory receptors can be modulated by hypoxia as well CCL28 FOXP3 PMC4026680__F1 Early life stress can influence development of the HPA axis, as well as regulation of satiety-related hormones, leptin, insulin, and ghrelin to alter feeding behavior long-term CRH AVP ARC PMC4391824__F3 Expression of the known genes involved in polo signaling in PAH HPASMC PRC1 POLE SMC3 APC SLK PMC3807757__F1 MyD-88 dependent TLR signaling pathway: MyD-88 (*) associates with the cytoplasmic domain of TLR, recruiting IRAK1 and IRAK4 to activate TRAF6 TLR7 TLR4 TLR9 IRAK1 TRAF6 IRAK4 MYD88 TLR1 TIRAP PMC11379068__F8 The interaction between the PERK/ATF4 branch of endoplasmic reticulum stress response and mitochondrial one-carbon metabolism after ICH ATF4 HEL-S-51e MTHFD2 PMC11549785__F1 LncRNAs modulate MR of solid tumor cells by targeting glucose metabolism ATG12 ENO1 MTOR IGF2BP2 DKFZp686F0183 PGAM1 HEL-S-133P HEL-S-68p PMC4768675__F9 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity DHX58 ATG12 CYLD UNK DKFZp686F0183 MAVS PMC10537991__F4 Quantitative Differences in Rumen Epithelium Proteins in Lambs Fed Wheat, Perennial Wheat, or Perennial Wheat plus Lucerne CBR4 ACADS HACD2 ACSF3 ACADSB IDH3B HSD17B8 MECR MCAT OXSM HTD2 PMC6305318__F2 Summary of the interactions between SIRT1 and the canonical Wnt pathway HMGB1 RUNX2 APC GSK3B SIRT1 PMC4768675__F6 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity EP300 ADA RBPJL PMC3714282__F1 Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway TH MPG PMC11549785__F4 LncRNAs orchestrate MR in solid tumor cells by influencing interactions between tumor and non-tumor cells in TME PFKFB2 CXCL14 HEL-S-133P PMC7074507__F1 TCR/CD3 complex and CD28 downstream signaling pathways leading to activation of transcription of genes for cytokines, chemokines, cell division, activation of effector function, and survival CTLA4 MTOR CDC42 PMC4768675__F7 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity NLRP3 TRIP6 RIPK2 PMC3522553__F1 Components of the Hedgehog (Hh) Signaling Pathway and molecular sites targeted by Hh pathway inhibitors SUFU SHH SMO PMC11549785__F2 LncRNAs modulate MR of solid tumor cells by influencing lipid metabolism NPM1 CPT1A HNRNPC ACSL1 FABP5 HEL-S-104 NR1C1 CD36 PMC9010455__F2 Upstream Regulator Analysis, based on “omics” integration using the Ingenuity Pathway Analysis software NPM1 CRABP2 ATF2 EGFR CD44 MTOR TAGLN CD81 ISG15 NFKBIA SMARCA4 MMP2 RELA TNFSF10 AXL JUN STAT3 PMC7841890__F4 Activation of the antioxidant signalling pathway by natural remedies against polyQ-induced SCA GCLC CYCS HEL-S-22 PMC8235637__F3 Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells KIT RET LAMP2 HDAC7 LPAR2 ARHA FLT3 MTOR LPAR1 LPAR3 CD36 LPAR4 PMC3132554__F2 Small-molecule inhibitors of the PI3K signaling network TSC2 BAD TSC1 MDM2 CASP9 PTEN RHEB PMC7484123__F1 Metabolism of hydrogen sulfide CTH SQOR ETHE1 SUOX PMC5546429__F8 Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice CDK5 MTOR BDNF PMC11084413__F5 KEGG pathway analysis of carnosic acid downregulated proteins associated with glycolysis/gluconeogenesis PFKL ALDH3A1 HEL-S-133P HK2 HEL-S-162eP PMC8948419__F5 Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans PMC9294245__F4 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells MDM2 BCL2 MCL1 BAX PMC9294245__F2 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells RSPO3 SMO PMC6843238__F2 ALDH1A1-retinoic acid-HIF-1Alpha-VEGF pathway is activated in breast cancer MCF-7 cells (A) RARB SOX2 ERBB2 CXCR4 MYC SRC HEL-S-53e CXCL12 RXRA TET2 PMC4889241__F4 p27 in cell-cycle regulation E2F4 GRB2 MCM7 RHO PMC12246546__F8 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors TRPV4 ARHA B3GNT3 PMC5691642__F2 Suppression of type I IFN production by Flaviviridae viruses TBK1 STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 MAVS PMC12246546__F5 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors ECT2 ATM CCND1 ARHA RHOB PMC6784043__F1 Novel insights into the dectin-1 signaling pathway CARD9 BCL10 SYK PLCG2 TRIM62 RAF1 NOS2 PMC2896660__F2 Placing datasets into a functional context using pathway analysis APP RPS24 PMC5822656__F1 MiRNA biogenesis, function in cytoplasm and nucleus-cytoplasm transport AGO2 DGCR8 DCP2 DROSHA PMC6089847__F2 Pathways of T-cell inactivation and mechanisms of monoclonal antibodies HAVCR2 CD80 CTLA4 TIGIT PMC7660678__F1 Pathway for the endogenous synthesis of arginine ARG2 ARG1 NAGS CP PMC5541427__F5 Effect of selecting different subsets of CpG sites in the “TNF signaling pathway” AGA CLPS BAGE JUN ITCH PMC6784043__F2 Crosstalk between different PRRs in antifungal immunity NLRP3 CARD9 MDM2 UNK SYK MYD88 IL1B IRF-1 PMC5541427__F1 Snapshot of PiiL in group-wise view mode, showing the “cell cycle” pathway CDC20 PLK1 SP2 ATM MYC TNF TFDP1 PCNA PMC6991658__F9 Mechanism diagram ATM CDK2 CDH2 PMC5921923__F1 Using gene expression data to direct breast cancer therapy: Evidence from a pre-clinical trial EGFR MYC SRC ARHA STAT3 PMC5541427__F2 “cytokine-cytokine receptor interaction” subsection of the “pathways in cancer” pathway, with (a) DNA methylation data, and (b) gene expression data PLCG1 EGF HGF EGFR MYC RALA CXCL8 RALBP1 PRKCA FGFR1 TFG CCND1 KITLG CDK4 ARAF JUN KIT PDGFRA FOS ARHA HRAS FLT3LG RET RASSF1 MAP2K1 IGF1 STK4 GRB2 JAK1 FLT3 TGFA CRB2 STAT3 PMC7781009__F1 MET oncogenic activation HGF ST7 STARD3NL TPR HLA-DRB1 CBL PMC9047906__F5 Serglycin Is Involved in TGFB Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue SMAD2 CD44 SMAD4 CREB1 SRGN TGFB1 PMC3887911__F4 CRAC channel regulation by multiple Ca2+-sensing molecules in the ER and cytoplasm CRACR2A ORAI1 STIM1 PMC3887911__F3 Interacting partners and posttranslational modification of Orai1 and STIM1 CRACR2A CDC2 ORAI1 STIM1 PMC3887911__F2 Activation mechanism of Orai1 and STIM1 VAV1 ZAP70 RAC1 ORAI1 LAT STIM1 CDC42 PMC9207250__F2 Vitamin D: A Potential Star for Treating Chronic Pancreatitis CYP27A1 NR1i1 AHR CYP2R1 CYP3A4 CYP24A1 CYP11A1 PTH CDC2 CYP27B1 PMC6390244__F4 Target-pathway network analyses results OMP ADRB1 ADRA2C PTGS2 ADRB2 TNF SLC6A2 GRIA2 ADRA1B SLC6A3 CHRM3 ADRA2A PKIA ADRA1D GABRA2 ADRA1A CHRM2 SCN5A PMC8866335__F2 Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies TRPC1 CYP8B1 LDLR ATF3 ARHA TRPC3 RHO BAX PMC2645860__F2 Pathogenetic mechanisms of CCAAT enhancer binding protein alpha (C/EBPA) dysfunction BCR EBP NOTCH1 TRIB2 CBFB PMC5015973__F8 Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming NODAL NANOS2 STRA8 SMAD4 PMC1779900__F6 Some signaling pathways that could mediate long-term changes in cellular plasticity as a function of sexual experience FOS CDK5 GRB2 SHE ARC PMC8620571__F1 An Atypical Case of Congenital Erythropoietic Porphyria ALAS1 FECH UROD UROS HMBS CPOX ALAS2 PMC4761092__F10 Scheme of the role of (+)‐naltrexone and (+)‐naloxone in TLR4 signalling IL16 TLR4 IRF3 MYD88 PMC4864395__F5 Menadione Suppresses Benzo(A)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism AHR CYP1A1 PMC12069246__F3 P38 MAPK signaling pathway is regulated by ubiquitination in MASLD USP4 TRIM16 TRIM38 TRAF5 CYLD FBXW5 TRAF3 TRAF6 MAP3K7IP1 TNFAIP3 TAB3 USP18 PMC3663533__F8 The regulation of TLR signaling by Lgr4 CD14 TLR4 LRP5 TRAF6 LRP6 MYD88 TIRAP PMC8998228__F1 Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family BAD BIK BMF HRK BAX BOK PMC10520882__F7 Biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype MTOR CAMKK1 CAMKK2 PMC7343490__F2 Network analysis including the 125 differentially expressed proteins at 24 h after SARS-CoV-2 in Caco-2 cells AFP F10 POLR2F CIT RANBP2 DCAF13 SP1 APOA2 LAMC2 APOE KRT14 SPC25 GPC3 PSAP ARHA CEBPA STAG1 LTBP1 AURKA AURKB NEDD4 MORF4L2 UBE2C USP16 HEL111 SDC4 VTN PMC3632385__F2 Schematic overview of estradiol-mediated genomic signaling pathway via ERA/B and rapid nongenomic signaling pathways via GPER, Gq-mER, and membrane subpopulation mERA/B EGF EGFR SRC PMC4522276__F1 Molecular Insight into Dengue Virus Pathogenesis and its Implications for Disease Control STAT1 CGAS STAT2 PMC7503882__F2 Molecular pathogenic signaling pathways in ACM NF2 SMAD2 GSK3B LRP5 SMAD4 LRP6 LATS1 LATS2 PMC5037500__F2 A glutamatergic synapse and the molecular circadian clockwork GFAP NACA PMC5346417__F5 Diagram showing the hypothetical model for regulation of NCC phosphorylation in the DCT cell, and hence the level of transcellular NaCl flux DCT KCNJ10 WNK4 PMC4350352__F6 TAp73 promotes anabolism SLC17A7 VAMP2 TP73 PMC5548957__F2 Rotavirus interactions with the host innate system: viral entry into cells and viral double strand RNA (dsRNA) induce the generation of pathogen-associated molecular pathways (PAMPs) TBK1 TLR7 IRF7 IRF9 RIGI IRF3 TLR3 PMC7911620__F1 TLR-activating adjuvants and the induced signalling pathway TLR8 TLR5 TLR7 TLR4 TLR9 CD80 CCL2 MYD88 TLR1 IL1B MPL TLR3 PMC6409969__F7 Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells MDM2 CDC2 AURKB BAX PMC11808623__F5 Mechanism of CSEAE regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway (Created with BioRender MVD APOE PMC2886300__F2 Role of ROS in TNFA induced endothelial dysfunction SKI TRAF4 PMC4462130__F6 a, Gene interaction map of Reactome pathway analysis that discovers alteration of FGFR signaling as the most altered pathway PIK3CD FGFR4 PTEN ERBB4 FGF23 FGFR1 CAMK4 FRS2 MDM2 ARHGEF7 PDGFRA CSK FGF6 GSK3A NRG1 CDC37 HRAS IRS1 FOXO1 RICTOR ERBB2 ADCY6 PIK3CA RAF1 PXN PHLPP1 PMC3998024__F2 Top-ranked gene network INPPL1 AKAP12 TRAFD1 FCAMR TRAF3 CCL4 TSLP DKFZp686F0183 WDFY3 LTA IFNA13 CD27 BCR RNASE3 ARF4 SERPINA1 PMC5799271__F2 TLR4 signaling pathways TBK1 TLR4 IRAK1 TRAF6 IRF3 IRAK4 MYD88 PMC10938783__F7 Multifaceted mechanism of KTC1101 in anti-tumor therapy and immunomodulation CXCL10 CCL5 MTOR IFNG PMC2874340__F1 Folate cycle, methionine cycle, and transsulfuration pathway HEL-S-61p PMC8507309__F5 RNA-Seq reveals different responses to drought in Neotropical trees from savannas and seasonally dry forests ATG12 ATG3 ATG101 EBF2 ATG10 DKFZp686F0183 PMC5729411__F7 Summary of the main findings APC MMP9 TLR3 EED PMC8228919__F1 Toll-Like Receptor Signaling in the Establishment and Function of the Immune System TBK1 TLR9 IRF7 IRAK1 UNC93B1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 PMC6891142__F4 The suppressive effects of Crabp1 in adipogenesis and adipocyte hypertrophy IGF1R IGF1 CRABP1 CEBPA IRS1 CEBPB PMC10857877__F6 RND3 induction and interaction with TLR4 and IFNG receptor signaling in activated proinflammatory macrophages CXCL10 NOTCH1 PMC7487489__F7 MAPK signaling pathway CD14 NLK MAX TRADD FLNA ATF2 GRB2 GCK ECSIT RAF1 TNF TRAF2 PMC4768065__F7 Proposed model of the involvement of Spry2 and Spry2 siRNA in TLR, IFNG receptor, and growth factor signaling pathways for suppression of M1 polarization and enhancement of M2 polarization in macrophages EGF MYD88 ARG1 SPRY2 IFNG PMC7226927__F5 Action of Hedgehog signaling pathway GLI3 SMO PMC7985092__F1 Schematic diagram of the insulin-like growth factor (IGF) signal transduction and main downstream effects BAD IGF1R IGF2 INS SHE PTEN DEPTOR IRS1 RHEB INSR TSC2 TSC1 IGF1 MDM2 GRB2 IGF2R PMC8904960__F1 Non-Canonical Roles of Apoptotic Caspases in the Nervous System APAF1 BAX PMC4666504__F7 Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake EGF ERBB4 EGFR NRG1 PMC6341984__F1 Tuberculosis and impaired IL-23-dependent IFNG immunity in humans homozygous for a common TYK2 missense variant STAT1 STAT2 STAT4 TYK2 JAK1 IFNAR1 IL23R IL12RB1 STAT3 PMC7337897__F6 MDM2 regulates E2F1 synthesis during EBNA1 mRNA-induced translation stress CDK2 MDM2 CDK4 CDC2 PMC9565759__F4 Possible Synergies of Nanomaterial-Assisted Tissue Regeneration in Plasma Medicine: Mechanisms and Safety Concerns PRC1 HEL-S-44 CCS STAT3 PMC7985092__F2 Several proteins in the IGF signaling pathway such as IGF1, IGF2, IGF-1R, and IGFBPs are regulated by miRNAs BAD IRS4 ELF3 IGF1 RUNX2 IGFBP1 IGF2 GRB2 MTOR IRS1 INSR PMC8275668__F6 Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis HRG CFB SFTPD HEL-S-99n AFM TXN CMPK1 C1QB MUC5AC SFTPA1 ARF4 CFP CDH2 B2M C1QC ARF3 PMC4365929__F3 Ultraviolet B (UVB)-induced cell cycle signaling and the relationship between p53 and phospho-Chk1 (Ser317) CCNB1 CDC2 ATR PMC3092200__F9 Hypothetic scheme of cell death induction pathway triggered roscovitine and CR8 in human neuroblastoma (NB) cells CCNH CDK9 CDK7 PMC4881378__F1 Components of the TLR signaling network frequently mutated in lymphoid neoplasms TLR5 CYLD ATF2 TRAF3 MYC TRAF6 IRAK4 MYD88 MAP3K7IP1 TIRAP TAB3 PMC6696953__F2 ASD gene networks constructed with PASCAL associated genes and its FunCoup interactors SUMO2 LYAR REN ALYREF NONO KCNN2 ADA GNL3 ILF3 HNRNPF CALM1 PMC8592893__F4 Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer GSK3B MYD88 JAK1 MTOR TIRAP PMC10815665__F3 Proposed conceptual framework for the involvement of CXCR signaling in modulating Th1/Th17-driven pathologies CXCR1 CXCR4 IL8RB CXCR6 IFNG PMC3871617__F5 NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria BCR CAV3 STOM APLN CAV2 PMC10815665__F2 CXCR signaling pathway CXCL1 CXCL10 CXCL8 CXCR5 CXCL2 CXCR6 CXCL13 CXCL16 CXCL9 CXCL6 JAK3 CXCL12 TF CXCL11 PMC6962170__F4 Integrated metabolic, proteomic and transcriptomic functional analysis ALAS1 MTAP PRMT1 AHCYL1 SMOX RARS2 HRH3 TUBA1B CHAC1 ASPA STAT3 PMC12107871__F5 Proposal of the main molecular signaling pathways by which celecoxib exerts its anti-inflammatory action as a promising strategy in breast cancer therapy TH COX1 PMC5336563__F2 Regulatory networks of selected lncRNAs involved in the development of HBx-HCC CDK2 DBH CCND1 CDK6 CCNE1 PMC4346366__F1 Consequences of tissue trauma on heme catabolism, reactive oxygen species, and polyunsaturated fatty acid metabolism.Notes: Top panel: following tissue trauma, release of free heme can serve as a signal for proinflammatory events PTGIS PTGS2 FES PTGES HEL-75 PMC11758948__F9 Cell division regulation by the EphA2–Ephexin4–RhoG signaling pathway ARHG CDC2 EPHA2 PMC7141213__F2 Examples of mechanisms involved in the cellular response to low doses of phytochemicals–on the basis of findings presented in the current review KEAP1 FOXO3A SIRT1 PMC12107871__F3 Schematic description of the signaling process demonstrating the intricate cross-talk between NFKB and STAT3 in inflammation-induced cancer MMP2 MMP9 BCL2 TNF STAT3 BAX PMC12107871__F2 Graphical depiction of mechanisms responsible for inflammatory response mediating the onset of cancer via STAT3 signaling pathway BIRC5 CXCR4 EGFR FZD2 CCND1 TGFA STAT3 PMC12107871__F1 Inflammatory signaling mechanisms underlying cancer development mediated by the NF-kB signaling pathway EGF BCR CXCR4 EGFR RELB CXCL8 CCND1 BCL2 CCL2 LTBR PMC7408754__F2 Gas6/Axl signaling promotes the immunosuppressive tumor microenvironment CCL4 CCL2 CCL3 PMC8391332__F1 Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection CXCL10 CRP MTOR ACE2 PMC4324046__F2 Metabolic reprogramming in rheumatoid arthritis T cells FASN PMC4295378__F1 WNT signaling network NLK APC CRP ARHA PMC3599859__F1 CySBGN overview COMP PMC4000313__F2 Death receptor signaling and programmed necrosis TRADD FADD PMC2991541__F3 Redox-control of Matrix Metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease UNK TNF PMC8891514__F1 Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection TBK1 NLRC4 IRF7 TRAF3 TRAF6 IRF3 MYD88 MAP3K7IP1 TLR3 NLRP3 SP110 IL18 TLR4 ECSIT TRAF2 AIM2 MVP MAVS PMC9481235__F1 AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis TH CARD18 TLR7 TLR9 AIM2 AURKA PMC7037245__F2 IL-2R signaling and modulation of T cell activity GAB2 GRB2 IL2 JAK3 EIF4E JAK1 EIF4B STAT5B SHC1 SOCS1 FOXP3 PMC2581785__F1 Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum LIPC PC FADS1 CAD PMC11880738__F5 Dual role of copper in melanoma ULK1 LOXL3 BRAF ULK2 S100A4 CCS PMC2894618__F2 Lineage relationships of cells originating in the otocyst FGFR1 SOX2 HEY2 ATOH1 GLI3 FGF8 FGFR3 SHH PROX1 FGF20 PMC7936661__F3 Short loop commonality and a landscape of short loop commonality among proteins with mutations in the AML PPIN KIT c-fgr INSR CBL PTPRB TNS4 PTPRG BCR MST1R PKD1 FLT3 FCGR2B SOS1 SHC1 MPL PMC8262770__F1 Metabolic Control of Smoldering Neuroinflammation TMEM119 HIF1A MTOR HK2 PMC3631012__F1 Mi-2/NuRD complex making inroads into DNA-damage response pathway INO80 MDM2 HDAC2 ATR H2AX PCNA RFWD2 PMC8794704__F2 Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis TRIM11 NLRC4 AIM2 IL1B PMC9582432__F2 Microglial autophagy in cerebrovascular diseases ULK1 MTOR PMC8363009__F6 Chemical-protein and protein-protein interaction network of cordycepin and unique proteins from DM+COR and shared protein from N+COR and DM+COR in livers on the hepatic metabolism pathway, analyzed by STITCH v 5.0 PRKAA2 PSMB2 PRKAA1 MTOR NFATC3 NR1C1 FOXO1 MDH2 PSMB6 ACO2 RFTN1 PRKAG2 OGDH PRKAG1 PSMB9 PRKAB2 PRKAB1 PMC6441168__F3 Functional network of cancer derived EVs in GC microenvironment HMGB1 TLR4 MSC PMC9352673__F5 Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies MAPK6 CD163 CD80 TNF ARG1 FUS IL1B SOX9 STAT3 CD36 PMC8447721__F1 Effective function of circular RNA in colorectal cancer CASP3 ITCH PMC11274312__F6 PPI network of the DEGs in immune-related pathways CD3D CTLA4 CD8A PPBP CXCR3 ITK TBX21 CD27 LCK STAT4 PRF1 CD3G LAT ICOS CD3E PDCD1 PMC5348722__F2 Translating genomic profiling to gastrointestinal cancer treatment BRAF SMAD2 IGF2 EGFR APC NRAS MYC SMAD4 PTEN MTOR FBXW7 ATM ATR PMC7892431__F3 Dysregulation of nucleic acid-induced signaling during HCC development STAT1 EGF CGAS CXCL10 AIM2 TLR3 PMC7892431__F2 Viral manipulation of DNA-sensing and directly antiviral signaling pathways TBK1 CGAS TLR9 IRF7 IRF3 MYD88 TRIM25 RNASEL ADAR NLRP3 TRIM56 EIF2A AIM2 IL1B MAVS IFI16 PMC5348722__F1 Translating genomic profiling to gastrointestinal cancer treatment SMAD2 EGFR MDM2 VEGFA SMAD4 CCND1 PTEN EZH2 MTOR CCNE1 PMC4295378__F3 The WNT signaling network on cancer cell metabolism TSC2 TSC1 APC GSK3B PMC7892431__F1 RNA sensing and viral manipulation of TLR and RLR signaling pathways TBK1 NLRP3 IRF7 IRF3 MYD88 CASP8 MAVS PMC5951828__F6 Potential role for AstC-R2 in nociceptor-bacterial-immune interactions in Drosophila HEL-S-11 TRPA1 PMC5069610__F2 NMI influences cancer initiation ATM GSK3B DRAM1 MYC MDM2 NMI PMC11575122__F9 CARMN mechanism involving transcriptional and post-transcriptional regulation MAPK13 KEAP1 YBX1 TFAP2A SP1 PMC4504941__F1 Molecular mechanisms of cardioprotection provoked by netrin-1 and netrin-1-derived small peptides SIAH1 SIAH2 DCC PMC5069610__F3 NMI inhibits cancer progression LEF1 TCF3 WNT3A SMAD2 ZEB2 TGFBR1 GSK3B SMAD4 NMI DKK1 TCF4 PMC6606950__F4 Herbal medicines promote the activation of the HIF-1 pathway through different targets in ischemic stroke MTOR STAT3 PMC6606950__F3 Chinese herbal medicines inhibit the activation of the HIF-1 pathway in cancer treatment through different targets TRAF6 PZP PTEN MTOR STAT3 PMC7476086__F8 Proposed schematic model: CRISPR/Cas9-mediated knockout of SHP2 inhibits breast cancer proliferation by regulating Cyclin D1 stability via the PI3K/AKT/GSK3B signaling pathway GRB2 CCND1 PMC5394831__F3 GnRH signaling pathway containing PLCB1 and MAP2K6 DAO MMP2 RAF1 CDC42 PMC6072563__F1 Schematic represents various signaling pathways that occur within tumor cells, which allow for cell growth, proliferation, and invasion EGFR CDK4 JAK1 CDK6 STAT3 PMC2747760__F1 Leptin signaling: A key pathway in immune responses STAT1 GRB2 PTEN IRS1 STAT3 PMC3903477__F1 Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways ACP2 HEL-S-5 PMC4121847__F6 Diagram illustrating the proposed pathway by which TLR4/caspase-8/inflammasome up-regulation induces the processing of IL-1B and promotes the inflammatory response in acute glaucoma NLRP3 IL16 NLRP1 PMC7352588__F3 DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer UBC UBB PMC8101316__F1 Proposed Parkinson Disease Genetic Testing Pathway SNCA PINK1 LRRK2 PARK2 PMC7352588__F1 Hedgehog signaling pathway SUFU GLI3 SMO PMC9490146__F3 Targeting cellular senescence to combat cancer and ageing TBK1 CGAS IRF3 IL6 IFNG PMC6017243__F9 The above-mentioned findings PDK2 CCND1 PMC7352588__F4 E3-ubiquitin ligases and DUBs involved in Smo regulation SMO HERC4 DUSP8 PMC8262770__F2 Metabolic Control of Smoldering Neuroinflammation CX3CR1 TMEM119 LPL CIC FABP5 ACLY MTOR APOE TYROBP CD36 PMC11880738__F1 Mechanisms responsible for copper uptake and homeostasis in cells SLC25A3 ATP7B SCO2 COX17 SCO1 ATP7A ATOX1 HEL-S-44 COX11 CCS PMC10189745__F1 IL-36 signaling pathway IL36A TRAF6 MYD88 PMC6521881__F2 Network of Neurotrophin signaling pathway MAP2K1 GSK3B GRB2 HRAS BDNF CRK IRS1 PMC8392047__F1 Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases TSC2 ULK1 TSC1 ATG12 ATG3 ATF4 ATG101 ATG10 ATG14 DKFZp686F0183 PMC5557744__F11 Schematic summary of the interleukin-6 (IL-6)/STAT3 signaling pathway, highlighting its central role in regulating the expression of multiple genes and cellular functions in metastatic breast cancer cells CCND1 STAT3 BAX PMC4813224__F3 Argininosuccinate synthetase (ASS)-negative cell death induced by arginine deprivation MTOR ASL BAX PMC6500763__F1 Signaling cascades involving EGR1, PTEN, DMP1, ARF, and the p53 network EGR1 BBC3 MDM2 PTEN TGFB1 PMC8714937__F4 LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis ABCA1 MTOR IL1B PMC6262272__F7A Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1 PIEZO1 LRP6 PMC8255928__F5 Integrative Analysis of lncRNA-mRNA Profile Reveals Potential Predictors for SAPHO Syndrome CLEC12A WDR73 OXSR1 MFSD11 MARCKS ANKRD42 ZNF316 IKZF3 HSF1 TIMM50 FCER1G MBD4 ZMAT3 EXPH5 ARHGEF40 FCAR MBNL1 PLEKHH1 TRIM13 ACADVL ZNF793 NPIPB11 LOXL1 ST3GAL1 EXOSC4 NPIPA3 SMIM14 ANKRD28 SLC31A2 PMC5668145__F5 Steady-state levels of TCA intermediates in control and KO livers and tumors and the expression of key enzymes in the glutaminolysis pathway CS CTRL GLS2 HEL-S-162eP PMC5606117__F4 Crosstalk between the genes (in blue) obtained from the systematic review of LR and their biological functions in the dopaminergic neurons UBC SNCA FYN DDC SRC ABCC8 HTR2A DRD2 PMC8533862__F8 Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses TBK1 STAT1 IRF7 IRF9 IRF3 TYK2 IRAK4 MYD88 JAK1 IRF2 IRF-1 MAVS PMC3640510__F2 Diagram representing possible mechanisms linking HCV-induced oxidative stress with hepatocarcinogenesis MDM2 DHCR24 NR1C1 NEIL1 PMC3367861__F2 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis EFNB2 IL7R JAK3 PMC2980759__F1 Examples of the inter-relationship between host, tumor, and environmental factors (pharmaco-epi-bio-genomic triad) that determine the response to tamoxifen in an individual patient (phenotype) SULT1A1 CYP3A4 SRC PMC11893596__F3 MLKL-related pathophysiological events in the endoplasmic reticulum and nucleus RIPK1 RIPK3 MLKL PMC11893596__F2 Pathophysiological actions of MLKL in the lysosome and endosome HMGB1 CXCL1 RIPK3 CXCL2 MTOR MLKL BAX PMC5216741__F6 MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis KRT19 HEL-S-97n HEL-S-15 HEL-S-116 MAGOH MTOR PAH PRDX3 AHR PCK2 DLAT NAMPT CRABP2 UGDH HEL-S-107 IL6 IDH3B HEL-S-130P HEL-S-49 CRIP2 HNF4A PSAT1 ASS1 ECHS1 PCNA PMC3367861__F1 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis PAK1 JAK3 GABPA JAK1 FOXO1 CDC42 PMC5807041__F11 Top deregulated networks in NL-20 cells: Hematological system development and function, immunological disease, lymphoid tissue structure and development network induced by Caki-2 cells defined by Ingenuity Pathway Analysis PRDM5 FER BTRC ARHGAP32 NKX2-3 GHR ARHGAP24 POLR2F TRIM69 TERF1 MME PMC4997391__F4 Urinary Metabolomic Approach Provides New Insights into Distinct Metabolic Profiles of Glutamine and N-Carbamylglutamate Supplementation in Rats PC NAGS ASL PMC5807041__F12 Significantly deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder and developmental disorder induced by Caki-2 cells defined by Ingenuity Pathway Analysis GPR37L1 ARL10 LBX2 HRBL WDR26 FIBIN TFRC HAUS8 CIDEB RHOU CCBE1 ZNF117 GMPR GRM3 MUC6 PMC8542015__F3 Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans KRI1 PMC6073630__F3 Disruption of ncRNA Networks in Cancer AGO2 PUM2 DIS3L2 C6 POLL PTEN E2F3 FOXO1 BCL6 POLI PMC5807041__F17 Deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder, developmental disorder networks induced by ACHN cells defined by Ingenuity Pathway Analysis GPSM1 XAB2 KMT2A RBPJ AFF4 OGT SMPD1 PIGR MED1 HCFC2 FOXK2 PMC2224366__F9 Innate immune modulation of CTL response to LCMV through MyD88 signaling PDC TLR7 TLR9 MYD88 PMC7499473__F1 Targeting CXCR4 CXCR4 MSC CXCL12 MTOR PMC9247256__F6 Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure RPS4X RPS2 RPL30 PFKM HEL-S-87p RPS3 PFKP TF PYGM RPS10 PMC6759650__F5 Enrichment in multiple cancer-associated networks in breast cancer COBL CITED1 KRT19 TTC9 SHANK2 UBE2T KRT18 XBP1 ATAD2 CELSR2 GPAM RET FOXA1 SLC7A2 TFF1 FMN1 PKIB TFAP2C HMGN1 CENPU GREB1 FKBP4 ZNF703 PMC6759650__F4 Mechanistic network analysis predicts multiple affected signaling networks MYBL2 FOXM1 NR3A2 FOS EGFR TP63 HDAC1 FOXO1 RARA EP300 CDKN1A TFAP2C IGFBP2 SP1 JUN SP3 PMC5489426__F2 Dual role of cellular prion protein in normal host and Alzheimer’s disease FYN SRC BAX PMC5779965__F5 Confirmation of some miRNA and target gene expression and integrative pathway analysis FBN1 SHE CDK4 PMC1785339__F4 Human and mouse mutations and the cognitive disorders affecting specific NRC/MASC signaling pathways and other postsynaptic proteins ERBB4 CASK GRIA3 PMC8229583__F7 17B Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway GFAP LPO SYP BAX PMC6315507__F2 Intermediary thiol metabolism in renal proximal tubular cells CTNS BLM DCC PMC5470994__F3 DE genes are significantly overrepresented in the Toll-like receptor signaling pathway TBK1 TH CHUK IFNA1 CD46 IL12A RCHY1 DOK1 MX1 IFNG STAT1 TNFSF6 OAS1 FYN CD209 CCND1 IL2 IL4 CD3D HEL70 CTSK IRF7 IL13 FOS IRF9 IRF3 IFNB1 IL6 TNF ADAR LIPE BBC3 NFKB1 TP73 PIK3CA EIF3S3 JAK1 IFIH1 MAVS STAT3 PMC8310949__F3 WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related Cardiovascular Diseases APC GSK3B LRP5 LRP6 FRZB PMC5808968__F1 KEGG database illustration of the MAP kinase pathway EGF NGF EGFR BDNF PMC5281575__F1 Metabolic control of macrophage activation TLR4 IL4 ACLY TNF PMC5855670__F2 Death ligand pathway TRADD FADD PMC9007636__F4 Expression Profiles of HOXC6 Predict the Survival of Glioblastoma Patients and Correlate with Cell Cycle MALL GCK HOXC6 ERAS COMP CPD PMC4281031__F3 PI3K-AKT-mTOR signalling pathway and associated hamartoma/overgrowth syndromes (PI3K subsumes PIK3CA and PIK3R2, AKT subsumes AKT1-3) TSC2 PTEN MTOR PMC5812543__F1 Isoprenoid formation PDC IDI1 IPP PMC10420029__F12 mTOR signaling pathway of P FLCN GSK3B RNF152 PTEN RHO EIF4E MTOR DEPTOR RHEB RICTOR SLC3A2 SESN2 SGK1 PMC10420029__F11 Fanconi anemia pathway of P REV1 FANCD2 BLM UBE2T RMI2 HES1 CLK2 FAAP24 ATRIP EME2 RAD51 POLI RAD51C POLK SLX4 EME1 RMI1 BRCA1 PMS2 FAN1 BRCA2 FANCM ERCC1 FANCL FANCA ATR FANCB FANCE POLM FANCG USP1 FANCF PMC3355730__F2 Co-expression of genes involved in lignin formation across species MYB SKI CAD TRIO PMC7855707__F2 In the absence of IFN (left), constitutively internalized IFNAR1 and IFNAR2 subunits may recycle from the sorting endosome to the PM VPS35 SNX2 SNX5 SNX6 IFNAR2 IFNAR1 SNX3 VPS29 SNX1 PMC8211811__F4 DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma TNFRSF12A ACTN1 GOPC MARVELD1 PDLIM7 DCBLD1 TLN1 GLIPR1 HEL-S-7 LPCAT2 OSMR SNX7 HRH1 MMP2 HEL162 IKBIP HEL114 CAV2 CALD1 LOXL2 HEL70 ANTXR2 BMP1 PLAUR SRPX2 ITGB1 CTHRC1 MMP14 MRC2 TMEPAI PXN CSGALNACT2 PMC6584916__F4 Downstream targets of Slit/Robo ROBO3 ROBO1 ROBO2 CDH2 MYO9B SLIT2 SLIT1 PMC10944040__F1 Molecular mechanisms of IL‐1 release NLRP3 TRAF6 IL1R1 MYD88 IL1B GSDMD TAB3 PMC6584916__F1 Structure of the Slit/Robo protein family and their interaction ROBO3 ROBO4 ROBO1 ROBO2 PMC10944040__F3 Antagonism of IL‐1 signaling pathway IL1R2 IL1R1 IRAK4 MYD88 PMC3409287__F3 ITIM-mediated signaling function of IDO IDO1 FYN SOCS3 IRAK1 RELB PMC6584916__F7 Roles of Slit/Robo in angiogenesis ROBO4 ROBO1 UNC5B SLIT2 PMC5480214__F2 Summary of ergot-alkaloid biosynthetic pathways with emphasis on Clavicipitaceae PMC10944040__F2 IL‐1 signaling pathway IRAK1 IL1R1 IRAK4 MYD88 IL1B PMC6584916__F6 Roles of Slit/Robo in neurocyte navigation ROBO3 SRC ROBO1 ROBO2 FLRT3 DCC PMC6584916__F5 Upstream regulatory molecules of Slit/Robo PML ROBO3 USP33 ROBO1 ROBO2 SLIT3 EZH2 SLIT2 SUZ12 EED PMC7176443__F3 Functional lncRNAs in signaling pathway RELA ARHA RAC1 CDC42 PMC12234997__F5 Protein-protein interaction (PPI) network analysis related to IMP and IMF and identification of their major effect genes PDE4D PRKCZ PPP3CA GPT ALDH3B1 NRAS ITGB6 CPT2 PFKFB4 HDDC3 RYR2 CCNG2 CRKL GPAM GPT2 CCL14 LPL MDM2 IL7R CASP9 NOS2 IRF-1 ENO3 FBP2 ATP6 NDUFA6 VEGFA MAP3K5 PIK3R3 PLCB1 ACKR4 NTF4 ABAT ELOVL5 CXCL9 ADCY6 HEL-S-19 CXCL12 ALDH2 CD36 KCNMB4 COX1 LAMTOR3 ND4L PFKM GADL1 CARNS1 LIPG PPP2R2A IL1B SGK1 IL2RB NDUFB11 AMPD3 NDUFS6 ACVR1 HEL-S-30 FOXO3A FGFR3 CAMK2G CYB ASPA BCL6 ANGPT1 COX6A2 ACADL NDUFB1 ND2 OGT EFNA4 IL33 ATP6V1F HEL-S-20 INHBB PYGL HEL-S-29 COL4A2 COL4A1 PMC7998429__F3 Nail organ markers and the requirement of the bone morphogenetic protein (BMP) signaling in proper nail development and differentiation PHLDA1 LORICRIN LGR6 PMC5822808__F1 Overview of Hippo-Yap signaling pathway NF2 LATS1 LATS2 PMC4709767__F6 Proposed pathways by which NRG-1 stimulates GSH synthesis and Cbl metabolism PI3 NRG1 CBL PMC11697911__F7 Graphical overview of the canonical role and potential regulatory mechanisms of the Notch signaling pathway on porcine oocyte maturation HEY2 DLL4 JAG2 DLL3 HES1 HES2 PMC3346990__F3 The potential molecular mechanisms of crosstalk between nuclear receptors LXR and FXR–SHP–LRH-1 regulatory cascade in the liver and intestine FGF19 FGFR4 CYP7A1 PMC6013567__F2 Activation of the anticipatory unfolded protein response by estrogen receptor A (ERA) EEF2K EEF2 EIF2A PMC3623797__F7 Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells NLRP3 IFNAR1 TRIM25 IL1B TLR3 MAVS PMC4212479__F1 Sphingolipid metabolism CERS3 DES CERS5 CERK SMS CERS2 PMC9650140__F1 Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis BMP7 COL1A1 SKP2 STAT3 PMC4875603__F6 Expression of genes that function in leukocyte activation in uninfected fetuses MPZ NPPA HAVCR1 opn MMP9 CD209 RBP4 SAA1 PMP2 TG BPI INHBA PMC8450769__F10 Albuca Bracteate Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating Beta-Catenin Signaling and Intestinal Flora CCND1 PCNA PMC6770018__F6 The key carbohydrate metabolic pathway and the miRNA–mRNA interactions in dmc TREH GPT GIP PMC9346324__F2 Retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review PC CERS3 LASS1 CERS5 SMS CERS2 CERS6 PMC6263089__F4 MTOR/S6K intracellular signal transduction pathways in the osteoclast TSC2 BAD NEK6 TSC1 SRC TRAF6 RAC1 EIF4E TNF MTOR TRAF2 CDC42 PMC3467356__F1 Regulatory network analysis of the top genes with SNPs with p<0.001 using MetaCore’s shortest pathway algorithm (GeneGo Inc.); the nodes that are circled are the genes of interest EGR1 NR1i1 IRF8 PTPRO SP1 PMC9279119__F3 Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer NLK MMP9 CCND1 PTEN PMC4113827__F2 TLR4 signaling pathway CD14 TLR4 IRAK1 LBP TRAF6 IRAK4 PMC2944875__F2 Gene Expression Study of Monocytes/Macrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts TH EGF FOS ENG TNF IFNG NOG CREBBP IL7 EP300 IL3 ZEB2 TOB1 TEF THBS1 SKI JUN INHBA PMC3560666__F7 Pathway in MAS and differentially expressed genes: as shown in Figure, IGSF4, PTPRC (CD45) and CD3D belong to a family of cell surface adhesion molecules CD3D ANXA1 MPO HBD CSK TPO BCL2L1 PROK2 PTPRC AZU1 BIRC3 CD226 CSF2 CSF1 CBLC IL1B BIRC6 ELL CD24 PMC7188750__F4 Application of microbial extracellular carbohydrate polymeric substances in food and allied industries PMC8821549__F3 TR-binding and regulation of genes in the hedgehog signaling pathway in intestine based on ChIP-Seq and RNA-Seq data HHIP KIF7 SUFU EVC BCL2 SMO SPOP PMC4735514__F2 Activation of the methylation cycle in cells reprogrammed into a stem cell-like state CTH HEL-S-61p PEMT PMC9558279__F1 PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond PTH GNAS MEF2C PMC8304173__F4 Therapies Targeting Metabolic Pathways in Cancer Stem Cells ALOX5 CPT2 ACLY SLC27A3 FASN STAT3 HEL-S-5 PMC8304173__F2 Therapies Targeting Metabolic Pathways in Cancer Stem Cells MEIS1 MYC ENO1 HEL-S-87p PMC4307326__F5 Some possible signaling pathways activated by SF-CSNPs which may regulate metabolism of proliferating cells through Ubiquitin C (UBC) RIPK1 EGFR TRAF3 MDM2 CD40 EIF4E MTOR PMC4307326__F4 Protein–protein interaction pathways are illustrated UBC CCNB2 PIK3CA CEP250 CDC2 MTOR BIRC6 ARID1A ACIN1 PMC5358695__F4 Layered network between rituximab and myasthenia gravis (MG) IL10 FCGR3A FCGR1A FCGR2A HLA-DRB3 IL6 FCGR2B TNF HLA-DRB1 FCGR2C BAX PMC5358695__F3 Identifying myasthenia gravis (MG) risk genes regulated by drugs and miRNAs in the hsa05200 pathway RARA APC INS SMO IL6 RAN CRK CRKL PMC5358695__F6 Layered network between sunitinib and myasthenia gravis (MG) KIT BRAF PDGFRA FLT4 VEGFA NRAS MYC CCR4 ADRB2 PTEN HRAS IFNG ERBB4 LTA KDR MAX CNTFR BCL2 CD55 CR2 FLT3 TGFBI BAX PMC5358695__F5 Layered network between adalimumab and MG IL10 BRAF FCGR2A IL6 TNF HRAS FCGR3B HLA-C IFNG FCGR3A HLA-DRB3 C1S FCGR2B BAX PMC3427262__F1 Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease IGF1 ATG12 ATF4 EIF2A BCL2 TRAF2 DKFZp686F0183 FOXO1 PMC5358695__F7 Layered network between muromonab and myasthenia gravis (MG) BRAF FCGR2A MAPK14 FCGR2C HLA-DRB3 IL2 IL4 FCGR2B CD3G ICOS CD3E BAX IL10 CD3D CTLA4 IL6 TNF HRAS HLA-B HLA-C HLA-A FCGR3A IL2RA CR2 PDCD1 PMC8875223__F1 Cellular Metabolism during Candida-Host Interactions NLRP3 PLG MYC ENO1 FOXP3 HEL-S-162eP PMC11666815__F1 Schematic illustration of the natural compound–induced protective effects against CVD damage through AMPK/SIRT1/PGC‐1A signaling pathway NLRP3 NRF1 TFAM PMC8811971__F1 IKK-mediated CYLD phosphorylation and cellular redox activity RIPK1 KEAP1 CYLD PMC3152294__F1 Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism NOTCH2 HES5 NOTCH4 HEY2 NOTCH1 NOTCH3 HES1 PMC5671973__F1 Recognition of human immunodeficiency virus 1 (HIV-1) by innate immune system TLR7 IRF7 TRAF6 IRF3 MYD88 TLR3 MAVS PMC10036758__F1 The complosome in health and disease HEL-S-62p C4B_2 CD46 VTN FH C7 C6 MASP2 CR2 C1S PMC1448211__F7 Real time pathway analysis of cell-cycle related genes mediated via TS overexpression in HCT-C18 (TS+) cells using actual gene expression data COPE APP ATR PMC11033207__F10 Redox signaling and skeletal muscle adaptation during aerobic exercise NOX4 HIF1A PECAM1 SIRT1 PMC9633954__F2 Pattern recognition receptor signaling and innate immune responses to schistosome infection NLRP3 IL16 SYK PMC9101426__F2 Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer HGF ERBB2 SMAD2 MYC SMAD4 PIK3CA JAK1 MTOR STAT3 PMC3117317__F3 NFKB signaling pathway EGF NGF LCK RELA RELB CD40 TNF TGFA BCAN LTBR PMC7137714__F6 Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse CDKN2D E2F2 BIRC5 TTK BIRC3 CCND1 IL6 ESPL1 BMP4 PMC2662580__F1 Wnt therapy for bone loss: golden goose or Trojan horse? APC WNT1 CCND1 WIF1 PMC7539779__F6 Mechanism by which SLFN5 regulates BRCA progression PTEN SLFN5 PMC9184225__F6 Improvement of Biosynthetic Ansamitocin P-3 Production Based on Oxygen-Vector Screening and Metabonomics Analysis GIP CIT MAL PMC5686191__F8 Possible mechanisms underlying how YAP regulated LRP1 by promoting proliferation and metastasis of melanoma cells and also reducing apoptosis MMP2 MMP9 PMC3459659__F1 Lipopolysaccharide/TLR4 signalling lipopolysaccharide recognition.Notes: Overview of LPS/TLR4 signalling LPS recognition is facilitated by lipopolysaccharide-binding protein and CD14, and is mediated by TLR4/MD-2 receptor complex CD14 TLR4 LBP MYD88 TIRAP PMC3762672__F1 PI3-K signaling.Notes: Activation of class I PI3-K via RTK phosphorylates and activates downstream target PDK1, in turn phosphorylating AKT kinases at the threonine site TSC2 TSC1 PTEN EIF4E RPS6 RHEB PMC8151225__F9 3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis CDH2 BAX PMC4364827__F3 Activation of the DNA damage response (DDR) after DNA double-strand breaks (DSB) induction in young and old cells RNF168 RNF8 ATM BLM H2AX PMC4454381__F4 Regulation of autophagy by protein post-translational modification OGA OGT HTT PMC150988__F1 JAK-STAT signaling and the generation of Th1 and Th2 cells STAT4 JAK1 PMC3648520__F1 Roles of DNA Helicases in the Mediation and Regulation of Homologous Recombination IL1A FBXO18 BLM BRCA2 RAD52 RAD51 RMI1 PMC4835209__F8 Conceptual schematic of the miRNA signal pathway regulated by TGFB2-OT1 in autophagy and inflammation NAT8L NUPR1 ATG3 LARP1 SQSTM1 RELA LASS1 IL6 TIA1 MTOR IL1B FKBP1A PMC8957988__F2 An Update of Long-Noncoding RNAs in Acute Kidney Injury PTEN PMC7429250__F3 Hypoxia-mediated glucose metabolism promotes dynamic O-GlcNAcylation of G6PD facilitating the utilization of PPP to produce NADPH for ROS detoxification OGT VHL NOX4 PMC6507272__F3 Role and expression of proteins identified by proteomic analysis within NAD+ metabolism and signaling pathway NUDT12 NAMPT NADK NNMT ASPDH NNT NMNAT3 NMRK1 NAPRT NMRK2 NMNAT2 NADK2 PNP PMC11657277__F9 Function and mechanisms of Chiglitazar in CML cells MTOR PFKP HK2 PMC9602982__F2 Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System DHCR7 HMGCR PMC3370667__F1 Schema of the FUS1 pathway EGF APAF1 EGFR MDM2 CASP9 BAX PMC6090437__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis of the hub gene secreted LY6/PLAUR domain and its connected genes KHDRBS1 CDKN1A ORC6 LIN54 GADD45A AKAP9 HEL-S-130P RAD21 CDK7 PMC8482240__F3 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level SPARC HEL-S-62p TWIST2 CHUK C4B_2 HSPA2 TGFBR1 MAP2K3 C4A CFD C7 MASP2 CFP CFB MAP3K5 IKBKB MAP4K2 C8A MAP2K1 MAX TWIST1 NFKB1 VTN C8G TRAF2 PMC6368612__F4 Wnt signaling pathway APC WNT1 GSK3B PMC3532379__F3 Functional “DASE” networks PTTG2 MMP20 DMBT1 USP6 ZNF331 PMC4260922__F2 Transcriptomic Immune Response of the Cotton Stainer Dysdercus fasciatus to Experimental Elimination of Vitamin-Supplementing Intestinal Symbionts ECSIT MYD88 PMC8217552__F4 Autophagy induction limits SARS-CoV-2 growth in vitro ULK1 TFEB EP300 ATG12 EIF5A DKFZp686F0183 SKP2 PMC7179076__F2 Wild type (wt) p53 and mutant (mut) p53 expressed in tumor cells on anti-tumor immune responses and inflammation CCL17 IL6 S100A9 STAT3 PMC3152494__F7 The crosstalk between the NOTCH and AKT pathways at the molecular and cellular levels TPO PTEN MPL PMC8630185__F1 Hemodialysis biocompatibility mathematical models to predict the inflammatory biomarkers released in dialysis patients based on hemodialysis membrane characteristics and clinical practices VWF C1S PMC10473147__F2 Neuroinflammation: A Common Pathway in Alzheimer’s Disease and Epilepsy GFAP IL1B CD68 PMC9521765__F1 Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications TSC2 TSC1 SMAD2 SMURF2 APC GRB2 SMAD4 PTEN RHEB STAT3 PMC8027653__F1 BAP1-mediated malignant signaling CCNA2 HCFC1 CCND1 RBL1 CCNE1 BAP1 PMC6158072__F23 Nrf2/AR signaling is at the crossroads of Wnt and Akt/FOXO signaling pathways KEAP1 GSK3B PTEN PMC7720132__F6 Summary of major impacts of challenge with Vibrio coralliilyticus RE22 and probiotic treatments with Bacillus pumilus RI06–95 and Phaoebacter inhibens S4 on Crassostrea virginica larval immune responses TRAF6 ATG9A PMC9170600__F1 Effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential NAPRT NAMPT NRK PMC9088190__F1 Methods for monitoring cancer cell pyroptosis NLRP3 HMGB1 WAS TNF GSDMC GSDMB GSDMD DFNA5 PMC5943908__F6 Summary of the vasoconstriction signal transduction pathways showing points of intervention by Xyl-B COX1 XYLB PMC8667473__F2 Review: The Role of Wnt/Beta-Catenin Signalling in Neural Crest Development in Zebrafish APC GSK3B LRP5 LRP6 DKK1 PMC8909674__F4 Mitochondrial Stress Response in Cancer Progression PINK1 ULK1 ATG12 ATG3 FUNDC1 ATG101 ULK2 BNIP3 DKFZp686F0183 OPA1 PMC2658594__F4 AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration LRP6 SOX9 PMC3549305__F4 GLUTATHIONE SYNTHESIS HEL-S-61p PMC11373551__F8 Identification of core regulatory genes and construction of partial correlation interaction networks related to taurine metabolism pathways CXCL1 MS4A1 PTGS2 APC DROSHA CCL4 CD74 CREB3 FYN ZFP36 LCK APP CD40 PMC6468754__F1 Hypoxia inducible factor (HIF) and vascular endothelial growth factor (VEGF) link the angiogenesis signaling pathways VCAM1 PMC8482240__F7 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level CPM FABP2 GM2A HEXA CHL1 CTSO SEC11C PSAP PADI2 CTSZ CTSG CPA3 RNASET2 CTSA CMA1 NLN ACE2 THOP1 MME ACADM PMC5677954__F6 Osteoblastic differentiation-related molecular mechanism under combined cytokine treatment IGF1 RUNX2 BMP2 PTEN MTOR SMAD1 DKFZp781O1323 PMC4875603__F4 T Cell Receptor (TCR) signaling pathway activation in endometrium of UNINF fetuses FYN CSK LCK GRB2 TEC SHB RAC1 SP1 LAT PMC8299113__F1 Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms RUNX2 BMP2 PMC8081922__F5 Beta-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts GIPR GIP PMC4130595__F3 Identifying a Polymorphic ‘Switch’ That Influences miRNAs' Regulation of a Myasthenia Gravis Risk Pathway IGF1R IGF1 BCL2 PMC8169871__F2 Alterations in brain metabolite concentrations and brain gene expression in AD SQLE CYP46A1 SC5D DHCR24 MVK CYP11A1 HMGCS1 WAS TM7SF2 CYP51A1 HMGCR CYP7A1 ACAT2 CYP27A1 CH25H PMVK MVD CYP3A4 DHCR7 FDPS FDFT1 PMC5490603__F3 Anti-inflammatory signaling pathways influenced by free zinc SMAD2 HEL164 SMAD4 IL2RA JAK3 PTEN JAK1 SMAD1 DKFZp781O1323 PMC5490603__F2 Pro-inflammatory signaling pathway influences by zinc TRADD IRAK1 IRAK2 TRAF6 MYD88 STAT3 FOXP3 PMC5490603__F1 Activation of Toll-like receptor (TLR) signaling pathways is mediated by a complex array of proteins TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR1 MAP3K7IP1 TLR7 TLR4 IL1B TIRAP PMC7288943__F8 Schematic diagram showing the mechanisms by which S58 promotes antioxidant defense of HConFs against fibrosis GPX1 TGFBR2 PMC8923649__F5 Correlation of SARS-CoV-2 to cancer: Carcinogenic or anticancer? (Review) BAD PTEN ACE2 TMPRSS2 PMC7868705__F1 Noncanonical NFKB Signaling Pathway in Liver Diseases RELA TRAF3 LTB RELB IL1B PMC2679904__F1 TLR mediated signaling TBK1 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 IRF2 TIRAP TAB3 PMC8969450__F2 Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis? HEL-S-62p TLR9 TRAF6 IRAK4 PLCG2 MYD88 TLR7 TLR4 SYK ACE2 IL1B TMPRSS2 STAT3 PMC7794007__F1 Diagrams depicting the Sestrins-mediated stress signaling pathways and functional domains of Sestrin2 in the regulation of metabolism and disease ULK1 KEAP1 RNF186 RBX1 IRS1 PMC3874163__F8 A simplified view of siRNA-enhanced DNA-mediated IFN-λ1 signalling pathway TBK1 IRF3 MAVS IFI16 PMC8473587__F1 p53 regulates glucose, lipid, amino acid, nucleotide, and iron metabolism TIGAR SCG2 HAMP PCK1 SLC7A11 SLC25A28 PDK2 FES MYC FXN PHGDH PANK1 SLC7A3 RRM1 RRM2 F2 ASNS CROT PCK2 HK2 FDXR PMC6925522__F2 LRRK2 and inflammatory signalling NAIP TLR4 LRRK2 NLRC4 TRAF6 RCAN1 TNF IL1B PMC3148026__F2 Pathway alterations involved in the development of low-grade serous carcinoma BRAF CCND1 MTOR PMC11939912__F2 Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders BAD GRB2 SHE RHO BDNF PMC11939912__F3 ProBDNF/p75NTR reverses the effects of BDNF/TrkB signaling, which activates the mTOR pathway to control actin remodeling and spine protein production, hence weakening dendritic spines [115] ARHA EIF4E MTOR BDNF EIF4B PMC3077082__F6 Microbial manipulation of receptor crosstalk in innate immunity TLR4 MYD88 STAT3 PMC12000012__F3 Divergent regulatory pathways in moderate erythropoiesis and excessive erythrocytosis EPOR EPO CSNK2B PMC3077082__F4 Microbial manipulation of receptor crosstalk in innate immunity CD47 RAC1 TLR1 PMC12000012__F5 Pathogenetic cascade of HAPC RET EPO SENP1 IL6 GATA1 PMC3077082__F3 Microbial manipulation of receptor crosstalk in innate immunity TLR4 CXCR4 GSK3B PMC12000012__F4 Hypoxia-regulated iron homeostasis and erythropoiesis ERFE EPOR EPO ALAS2 TF TFR2 PMC3077082__F2 Microbial manipulation of receptor crosstalk in innate immunity TH CLEC5A ARHA SYK IL6 RAF1 MYD88 TNF PMC3077082__F1 Microbial manipulation of receptor crosstalk in innate immunity HLA-E MARCO SYK CEACAM1 PMC10723408__F1 Workflow and methodology used in this work EMD VIT SET CIT PMC7835030__F7 NLRC4 gene regulates inflammatory reaction and immune response of DCs in septic shock by mediating the NLR pathway NOD1 NLRC4 CD80 IL1B NOD2 PMC8057295__F1 SHH pathway in the (A) absence or (B) presence of the SHH ligand HHIP KIF7 GPR161 GSK3B KIF3A SMURF1 SUFU SMURF2 PTCH1 GLI3 SHH SMO SPOP ADRBK1 PMC3852078__F6 BDNF-related PPI network UBC ELAVL1 BDNF ELAVL2 PMC8057295__F2 Schematic presentation of upstream regulation of the SHH signaling pathway and its associations with other cancer-related cellular pathways EGF E2F5 SHH ZIC2 RORA HIF1A MTOR CDC73 FOXA2 PMC8144890__F3 Energy metabolism disorders and potential therapeutic drugs in heart failure TSC2 TSC1 F2 TBC1D7 RHEB PMC8057295__F4 Models of the SHH signaling pathway in cancer SUFU PTCH1 SHH SMO PMC9573421__F5 Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy KEAP1 RBX1 IL1B PMC7508496__F2 BMP 7/Signaling Antagonizes TGFB−Induced Organ Fibrosis: MechanismBMP-7 and TGFB1 bind to distinct type II receptors that form complexes of specific type I serine-threonine kinase receptors SMAD2 SMAD1 TF DKFZp781O1323 PMC3976861__F2 Representation of the p53 signaling pathway map from KEGG ATM RAN RFWD2 BAX PMC4442748__F1 M1 and M2 Immune Activation in Parkinson’s Disease: Foe and Ally? SYK TYK2 JAK3 JAK1 TNF ARG1 IL1B SOCS1 STAT3 PMC6275025__F1 Insulin signalling pathway IRS4 GSK3B PTEN IRS1 PMC5302945__F3 Seven protective miRNA signatures for prognosis of cervical cancer MYB FOS PTGS2 VEGFA MYC NOTCH3 SUZ12 ARID1A SOX9 EED EP300 ATM EZH2 NOTO PRKDC PMC2593123__F1 A simplified schematic of the core left-right signaling pathway in the e8.5 (6 somite) mouse embryo LEFTY1 NODAL LEFTY2 PMC6981493__F5 Representation of the cellular response after insulin stimulation BAD GSK3B BAX PMC7443512__F5 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission ACE2 TMPRSS2 PMC8719288__F1 Building Resilience with Aerobic Exercise: Role of FKBP5 GC BDNF PMC5456285__F6 HCoVs on ER stress response ATF4 EIF2A XBP1 PMC9929940__F5 Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern CD1D BCR CCR7 CCL17 CXCR5 CD40 CD80 ICOS IFNG PMC5456285__F5 HCoV viral proteins on innate immunity STAT1 STAT2 IRF3 TYK2 MYD88 JAK1 IRF-1 MAVS PMC6900528__F6 The proposed pathway of IPs synthesis ITPK1 IPMK PMC7443512__F2 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission NLRP3 TLR8 TLR7 IRF7 IRF3 MYD88 TNF IL1B TLR3 PMC8849228__F8 Transcriptome Profiling During Muscadine Berry Development Reveals the Dynamic of Polyphenols Metabolism TCP1 CS C6 CAD AGL COA3 PMC10433440__F6 (A and B) Illustration of classical and non-classical Wnt/Beta-catenin signaling pathways APC PMC6882007__F1 Hh signaling pathway transduction KIF7 SUFU SMO PMC2814417__F7 The postulated signaling of MAP kinase pathway in proliferating or differentiating HL60 cells CD14 NR1i1 EBP KSR1 PMC5342665__F1 Steps in the LDLR metabolic pathway PCSK9 LDLR PMC7287178__F2 Proposed model of the cardiac sarcostat BAG3 HEL-S-101 CA3 HSPB8 NBR1 HEL55 PMC4982475__F6 Simvastatin and dLGG mediate formation of oxylipin mediators by regulation of MAPK-induced cPLA2 activation and downstream signaling cascades LTA LBP PMC3841149__F9 WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation WNT3 PTCH1 LRP5 SHH LRP6 SMO PMC9090832__F7 Olig2-Ddx20 axis-mediated suppression of p53 pathway GEMIN6 MDM2 GEMIN7 GEMIN8 GEMIN2 GEMIN5 OLIG2 PMC7797087__F1 Schematic model illustrating the cross-talk between the ET-1R axis and the YAP pathway SRC TF PMC6881651__F10 The Action circTTN Competitively Sponging miR-432 Mediating Myoblast Proliferation and Differentiation MYF5 CDK2 IGF2 CCND1 MYOG PCNA MYOD1 PMC7764760__F2 An EGFR-centric view of EV biogenesis EGF EGFR GRB2 CP PMC11352233__F7 HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer SMAD2 EGFR SMAD4 PMC7764760__F3 Pathway diagram of EGFR post-endocytic fate TSG101 EGF BTC PLD2 EGFR ARHA RHO ARF6 TGFA PMC5954861__F3 TBP-2 snd p38 MAPK-NFKB signaling pathway COX2 TBP POR OPTN S100B PMC12110717__F2 Schematic view of membrane channels, Ca2+ and inorganic phosphate (Pi) ion trafficking and amorphous calcium phosphate (ACP)/HA formation TMCO1 PANX3 PMC7768823__F1 Actionable nodes of the autophagy pathway ULK1 ATG12 ATG3 AMBRA1 ATG101 ULK2 ATG10 DKFZp686F0183 PMC5954861__F6 TBP-2 regulates autophagy and apoptosis of HLECs under oxidative stress CASP3 TBP MTOR BAX PMC10917928__F2 TCM polysaccharides’ role in regulating tumor adaptive immune response BCR SYK PMC10917928__F1 TCM polysaccharides’ role in regulating tumor innate immune response CD14 TANK TLR4 TRAF6 MYD88 PMC5068743__F5 Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis OTUB2 FOLH1 ADAM9 UBR5 HEL-S-107 TXLNA DHRS1 PSMB6 CKAP5 VCPIP1 STEAP2 UBE2V2 ATF4 CDC2 MTDH PMC4409326__F2 MicroRNAs in the pathogenesis of cystic kidney disease DGCR8 DROSHA PMC8599717__F2 Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology YTHDF2 YTHDF1 METTL3 CCR4 XRN1 WTAP PMC8289871__F10 Cartoon depicting the putative molecular mechanism for insulin protection of pancreatic acinar cells during acute pancreatitis F2 ADA GLA PMC11040167__F6 Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells MAF KEAP1 ATR PMC10140937__F4 Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number SDHC ME2 CS TRAF3 DLD HLA-DQB1 MDH2 CAP2 FH OGDH SUCLG2 ME3 SDHD PMC7103059__F3 Signaling pathways in osteoclast activation FOS MMP9 SRC TRAF6 CD80 TRAF2 PMC3585436__F3 p110D PI3K pathway in B cells CD14 CXCL13 BTK TLR4 BCR LYN CXCR5 CD40 SYK PLCG2 IL4 CD19 PMC3585436__F2 Simplified scheme showing the critical role of Class IA PI3Ks in multiple cellular functions TSC2 BAD TSC1 GSK3B PTEN RHEB PMC3585436__F4 p110D PI3K mediates the effects of CSF-1 or EGF via RhoA and PTEN in macrophages and some solid tumor cells EGF SRC ARHA PTEN PMC3680388__F5 Novel Strategy to Increase the Proliferative Potential of Adult Human Beta-Cells While Maintaining Their Differentiated Phenotype ACTA2 SMAD2 GSK3B SMAD4 RRH NKD1 TET1 UGT2A2 FZD2 FZD7 SFRP1 MCM10 NPC2 RUNX3 PDGFRA RUVBL1 UGT2B10 LRP5 UST DVL3 WNT3 WNT3A TYK2 JAK1 TCF4 STAT3 COL4A1 PMC5608693__F6 Model of step-wise progression in DPN-like melanoma BRAF APC CDKN2A ARID1A TERT TET2 PMC2727867__F1 Representation of some zinc-induced apoptotic pathways F2 F3 PMC6007054__F8 Diagram showing effects of 4-HNE on Keap1- and GSK3Beta-mediated Nrf2 degradation KEAP1 GSK3B PTEN PMC10976824__F2 Infection of endothelial cells by pathogenic microorganisms triggers the activation of the NFKB pathway, resulting in increased levels of HIF-1A TRADD TRAF6 IRAK4 MYD88 TNF TLR1 RIPK1 CARD9 TLR4 BCL10 SRC SYK TRAF2 MAVS MAL PMC3926505__F3 Roles of Cu in synaptic function ATP7A ATOX1 PSD PMC3926505__F1 Key organelles and proteins involved in cellular Cu homeostasis COX17 ATP7A ATOX1 APP HEL-S-44 BDNF CCS PMC5819894__F11 Metabolic enzymes targeted by p53 SCO2 HK2 PMC4414174__F9 Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer MTOR TRAF2 TRAF4 PMC6963500__F9 Activation of the Wnt/Fz ligand-receptor leads to the production of the second messengers IP3 and DAG from membrane-bound PIP2 via the action of membrane-bound enzyme PLC CASR RUNX2 BMP2 PMC9420645__F1 Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease TLR4 IRF7 TRAF3 TRAF6 IRF3 MYD88 TIRAP TAB3 PMC4831844__F2 Computational Reconstruction of NFKB Pathway Interaction Mechanisms during Prostate Cancer GPR17 SNAI1 AREG BMP2 LIF PTGS2 IER2 RRAD CXCL3 PTX3 RELA STX11 IRF-1 PMC8817839__F2 CGRP: A New Endogenous Cell Stemness Maintenance Molecule AQP5 SHH TRPV1 PMC7746538__F2 Cathepsins in macrophage functions during bacterial infection CTSL NLRP3 CTSK CTSS LAMP2 EEA1 IRF3 MYD88 HEL-S-130P TLR3 PMC4922528__F2 TLR and NLR signaling CD14 TLR5 IRAK1 IRAK2 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 NLRP3 TLR7 TLR4 IL1B TIRAP PMC3827948__F6 S4 controls FGF2-mediated signaling through RhoG-dependent macropinocytosis of the FGFR1-S4-FGF2 signaling complex ARHG FGFR1 FGF2 PMC9604716__F3 LL-37 in Bone and Periodontium Regeneration TLR4 IGF1R EGFR FPR2 PMC8386479__F7 Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming PMC12044029__F6 Bone-derived factors regulate renal functions FGF23 SOST LCN2 DKK1 SGK1 CYP27B1 PMC6305653__F2 Signaling pathway analysis of KEGG and PANTHER pathways shows that the miR‐34a/BCL‐2 axis is mostly involved in apoptotic pathways CASP6 BAD CASP12 TRADD MYD88 CASP3 ATM HEL-S-11 IL3 CASP9 TRAF2 CASP8 FADD BAX PMC9656419__F3 Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease STAT1 MYC STAT3 PMC8377544__F5 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man TSC2 TSC1 FOXO3A NOX4 PTEN SIRT1 UCP2 PMC9257083__F6 Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis NOD1 DAP TNF PMC8377544__F4 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man EGFR GSC PMC2917144__F1 Toll-like receptor signaling pathway TBK1 TLR4 IRAK1 HEL-S-71 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TIRAP TAB3 PMC3772104__F2 Involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis CCL26 CCL24 JAK1 PMC3772104__F1 The involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis JAK3 JAK1 LORICRIN GATA3 FOXP3 PMC6947643__F2 The gamma secretase (Gamma-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin ADAM10 ADAM17 HES1 PMC11734646__F9 SCF involves in the regulation of immune response FBXL19 FBXO3 AIRE PKD1 FBXW11 FBXO21 PMC5802154__F8 Intracellular signaling mechanisms that induce epithelial mesenchymal transition during CSE-induced aberrant EGFR activation in human RPE cells SRC SYK TGFB1 RPE PMC8286839__F8A Figure 8.NFKB dependent inhibitory feedback at the receptor level CD14 TLR4 CSA2 PMC2610366__F1 Pathways involved in folate-dependent methionine transmethylation and transsulfuration PMC4945639__F2 WNT/Beta-catenin signaling pathway in adrenal tumorigenesis ZNRF3 APC GSK3B LRP5 LRP6 PMC9313047__F3 Pathological Features and Neuroinflammatory Mechanisms of SARS-CoV-2 in the Brain and Potential Therapeutic Approaches TH CCL4 CCL2 ACE2 TLR3 PMC7281661__F6 LAB-mediated modulation of inflammatory responses in bovine mammary epithelial (BME) cells IL1A TLR4 SIGIRR CXCL3 CXCL2 MYD88 PMC4298363__F7 Suppression of ghrelin signaling mitigates age-associated thermogenic impairment MFN2 COX2 GHSR UCP1 IRS1 OPA1 PMC6835776__F3 Proposed effects of ZnO nanocomposites on antigen-presenting cells and their potential role in inducing T cell responses in draining lymph node NPS MYD88 IFNG PMC8529605__F5 Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking RHOD FBL EPO DAO VHL PFKL POR HEL-S-133P BPI PMC7504796__F3 Interdependence of CAT:MST axis, glutathione (GSH) bioavailability and cysteine metabolism HEL-75 PMC7504796__F1 Role of the glutamate oxaloacetate transaminases: 3-mercaptopyruvate sulfurtransferase (CAT:MST) axis in promoting and sustaining cancer KEAP1 MCAT PMC9340905__F1 Next-generation selective estrogen receptor degraders and other novel endocrine therapies for management of metastatic hormone receptor-positive breast cancer: current and emerging role EGFR CCND1 CDK4 ENG MTOR CDK6 PMC9409144__F1 Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity—Receptors and Signalling Mechanisms FYN IRAK1 PDE3A SRA1 LYN UNK ARHA SYK IRAK4 MYD88 CD36 PMC3123543__F4 Overlaid networks predicted by the PLS method and generated by IPA pathway designer ELF2 EREG MIDN TES PMC1297640__F1 Systems and molecular complexity in glycobiology GNE NAGK KY CD34 GCK GAL FPGT GFPT1 PMC9262756__F2 Aberrant expression of miRNAs in epilepsy NOTCH2 HES5 NOTCH4 DLL4 APC NOTCH1 HEL-S-92n ADAM10 DLL3 NOTCH3 HES1 PMC3233204__F4 DEVELOMENT AND NEUROGENIC POTENTIAL OF MÜLLER GLIAL CELLS IN THE VERTEBRATE RETINA EGF RAX CCND3 PMC6457004__F5 Schematic model in which HMW FGF2-mediated FGF23 stimulation of chondrocyte differentiation and OA is partially through modulation of the Wnt/Beta-catenin pathway FGF23 ADAMTS5 SOST FGF2 AXIN2 WNT7B PMC6103261__F1 Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays LTA PC COX1 LTB PMC5921900__F2 Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges CCL17 CCL28 CCL2 CXCL12 CCL22 CSF1 PMC4110655__F2 Proposed mechanism of action of the erythroid regulator ERFE ERFE EPO PMC8064803__F2 Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma NLRP3 TLR4 MYD88 C1S PMC8300636__F1 Relevance of Plant-Derived Se Compounds to Human Health in the SARS-CoV-2 (COVID-19) Pandemic Era CS HP SEPSECS PSTK CBL PMC8783100__AF1 Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry ATM ATR ORAI1 PMC5161753__F5 Summary of the mechanisms for LAPTM4B promoting cancer development EGF LAPTM4B FOXO4 MMP2 GSKIP MMP9 EGFR CASP9 PMC7677142__F1 Subcellular localization of the cholesterol biosynthetic pathway in mammalian cells INSIG1 BAAT PMC9279817__F7 MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6 RUNX2 BMP2 SMAD6 SMAD4 SP7 SMAD1 DKFZp781O1323 PMC10963404__F6 Mode of action of DMXAA and its derivative HHMX in human and mice TBK1 CGAS IRF3 IL6 PMC5732764__F1 Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model MTAP SMOX SRM PAOX TYMS AMD1 SMS PMC2757227__F1 Regulation of ENaC and CFTR by SGK1/Nedd4-2 PDK2 SGK1 CFTR PMC7319342__F7 ROS regulation of RAS and vulva development in Caenorhabditis elegans DUOX2 HEL-S-44 PMC8167992__SF1 Targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer VEGFA S1PR1 STAT3 PMC8476858__F1 Editorial: Intracellular Mechanisms of Alpha-Synuclein Processing PTMS BAG5 HEL-S-130P PMC7468876__F2 Schematic representation in IPA of the ILK signalling pathway NCK2 BMP2 MMP9 PTEN NACA MTOR KRT18 CASP3 COX2 RICTOR LEF1 UNK HEL113 JUN PXN PMC9377691__F3 Supramolecular organizing centers at the interface of inflammation and neurodegeneration TBK1 CGAS TRAF3 TRAF6 IRF3 MAVS PMC5031543__F3 HGF signaling pathways; A) Representative structures, cMET binding affinities (KD) and dimerization of HGF, NK1 (cMET agonists) and NK2 (cMET antagonists HGF RAF1 PMC5812256__F1 Bile Acids in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 BAAT PMC7242157__F1 Metabolic, renal and neural health are impacted by a ketogenic diet NLRP3 FGF21 CREB3L3 MTOR ACE2 NR1C1 PMC7932549__F2 Overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine POLD2 PCLAF EYA2 TDG NBN UBB DTL TIMELESS POLE4 POLE MBD4 BABAM2 APEX1 HUS1 SPIDR FAAP24 ATRIP CENPX CENPS EME2 UBA7 WDR48 MDC1 BARD1 LIG1 RBX1 MRE11A KPNA2 VCP ATR PCNA SUMO1 TERF2 BLM NSD2 PARG CHEK2 UBC ISG15 EYA1 ATM POLK RPA1 SLX4 EME1 BRCC3 POLN MPG RFC3 RFC4 RFC1 RFC2 FANCM FANCL FANCA OGG1 ACD PNKP FANCE FANCG PMC4650856__F4 Wnt signaling pathway involved in SPN LEF1 AMACR CTNND1 PMC7985179__F2 Key proteins and interactions in coronavirus disease-related pulmonary fibrosis (COVID-PF) EREG DPP4 ALB GSK3B WT1 NOD2 FGFR2 CLU PRKCA CGB8 FGF10 APP HEL-S-44 CD40LG FURIN ACE2 NTRK2 IL1B CENPA APOE CD68 CENPB NTRK1 VEGFA FGFR3 NRG1 CGA IL6 TNFRSF11B TNF GUSB HMGCR PRL PTX3 IGF1 MUSK BUB1B VTN CD80 CSF1 BDNF IRAK3 PPARG TGFB1 CP TGFBI PMC6079124__F1 Several Proposed important schematic signaling pathways for Gankyrin in tumorigenesis IRAK1 RELA ARHA PTEN IL1B STAT3 PMC6643872__F2 ETC and ATP synthase are required for normal eye development COX2 ZNF183 NDUFS1 NDUFB8 NDUFA12 COX10 NDUFA9 NDUFA11 COX7C SDHD NDUFS8 SDHA SDHB NDUFS4 SDHC NDUFB9 NDUFA6 NDUFC2 NDUFB7 NDUFB3 ND5 ND4 COX1 ND4L NDUFA5 FH NDUFA13 NDUFB10 COX11 NDUFS5 NDUFB6 NDUFB5 NDUFB11 NDUFS6 NDUFV2 NDUFA7 NDUFB2 NDUFAB1 NDUFS3 CYB COXFA4 ND6 NDUFA2 NDUFB4 COX3 ND3 COX17 NDUFB1 ND1 ND2 NDUFA10 PMC8931059__F3 CD95-dependent non-apoptotic signaling PLCG1 PTEN MTOR ORAI1 PMC8931059__F2 CD95-dependent apoptotic signaling CASP3 FADD PMC11643440__F2 Insulin signaling pathway in adipocytes in healthy and obese (pathologic) subjects FOXO3A F3 FOXO1 PMC12090549__F5 For combining inhibition of the adenosinergic pathway and other cancer immunotherapies APC ADA PMC8143539__F3 Using Pharmacogenetics of Direct Oral Anticoagulants to Predict Changes in Their Pharmacokinetics and the Risk of Adverse Drug Reactions CES1 HP CYP3A4 PMC12090549__F4 Immunosuppressive effects of adenosine within the tumor microenvironment COX2 CD80 CXCL12 TNF PMC7656123__F3 Identification of an important regulatory role for miR-574-3p-mediated signaling pathways (especially the EGFR/RAC1 pathway) in spinal chordoma by integrated analysis of both the miRNA-mRNA and protein-protein interaction networks data EPGN MAPK8 EGFR SMAD4 HBEGF CLDN2 RAC1 MKRN1 NEDD4 RXRA BCL6 APOB NR1i1 P2RY2 WASL NRP1 ADAM10 CLTC TNS1 IRF4 PMC12090549__F1 Adenosine production and signaling pathway ADA PNP PMC7998716__F1 Activation of Tyro3, Axl and MerTK (TAM) receptors on cancer cells results in downstream oncogenic signaling MMP9 RALA TYRO3 RALB RHO MERTK MCL1 AXL PMC8024568__F1 IL-10, 13, 17, and 33 interaction mechanism with their specific receptors IL33 TRAF6 TYK2 MYD88 JAK1 STAT3 PMC10459248__F2 Cellular pathways modulated by ASFV CD58 CGAS ULK1 CD1D PPP3CA TRIM21 IFNGR2 IFNLR1 NLRP3 STAT1 KPNA4 VPS39 CD163 KPNA3 IFNGR1 CSF2RA NPC1 STAT2 IRF7 LAMP2 IRF9 IRF3 IFNAR2 IFNAR1 IL10RB EP300 KPNA2 TYK2 JAK1 STAT3 PMC11890030__F1 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology SET IPP PMC11890030__F3 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology MYB MYC ERF IPP PMC9633854__F3 Choroid plexus epithelium and its role in neurological diseases CP IFNG PMC4451983__F2 Functions of lncRNAs in autoimmune cells, T cells, B cells, macrophages, NK, and dendritic cells WDR5 HNRNPL CCR1 IFNG STAT3 PMC5035020__F4 Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection RPEL1 NODAL GRB2 GSC TLK2 SKI PMC5356817__F5 Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm TNFSF8 CD14 CYBA MYOT LY86 ACTG2 ROCK1 AIF1 DES PRKG1 TLR1 THEMIS2 LCP2 IGSF6 MYOM1 CTSC HEL-S-273 ADRA1A FCGR2B C1QC MYLK PMC7350910__F4 Crosstalk between the TNF-related pathway and CS response GC TNFRSF10A TNF FADD PMC5074868__F8 MYELOID HSF1-Beta-CATENIN AXIS REGULATES NLRP3 INFLAMMASOME ACTIVATION IN MOUSE LIVER ISCHEMIA/REPERFUSION INJURY NLRP3 TLR4 TRAF6 MYD88 HSF1 IL1B PMC9359082__F2 CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment SOX21 CMTM6 MTOR CMTM4 PMC6771392__F7 Model of HROB function in homologous recombination MCM9 RAD51 HELQ HROB PMC8268587__F1 Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics BAMBI APC CRIM1 LRP5 SMAD6 SMAD4 LRP6 DKK1 SMAD1 DKFZp781O1323 PMC4714567__F6 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs AHR CDK2 CYP1A1 KLF6 PMC4714567__F5 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs AHR KLF6 PMC3530773__F3 Vasopressin signaling network TP53BP2 MINK1 BAD PHKB LRRFIP2 RYR1 MAPK14 GNAS CAMK2A ASB4 PMC4714567__F3 Ah Receptor Pathway Intricacies MAF AHR RELA CYP1A1 KLF6 PMC7864232__F7 Diversity and Biology of Cancer-Associated Fibroblasts PTCH1 SHH SMO PMC4714567__F2 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs AHRR AHR STC2 PON1 BAX PMC7519530__F6 Hypothesized role of miR-142-5p and miR-365a-3p in CML signaling ABL2 SRI BAD GRB2 CASP9 MCL1 MTOR BAX PMC11918467__F6 H2 can protect H9c2 cells from H/R injury by inhibiting the Wnt/CX3CR1 signaling pathway HMGB1 TLR4 CX3CR1 APC PMC8267696__F1 Metabolic Reprogramming: A Friend or Foe to Cancer Therapy? APAF1 MCL1 FADD BAX PMC8869954__F1 RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart GSK3B MYC MAPK14 NOTCH1 SRC RAF1 JAK1 ADRBK1 STAT3 PMC5332476__F1 The role of Rho GTPase/Rho kinase signaling pathway in regulation of actin cytoskeletal organization and cellular processes in smooth muscle and non-smooth muscle cells ARHA RHO LPA PMC5332476__F2 Inhibitors of Rho GTPase and Rho kinase lower IOP by increasing aqueous humor outflow through the conventional pathway and exhibit neuroprotective effects by stimulating axonal outgrowth and retinal ganglion cell survival HEL-S-62p ARHA RHO PMC9180238__F1 MicroRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor PTEN MTDH MTOR FOXR2 PMC6797603__F1 NLRX1 regulates immune system signaling NLRP3 TUFM NLRX1 TNF UQCRC2 MAVS PMC4857091__F6 Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome EIF6 MTOR SBDS PMC9433407__F9 Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response HEL-S-26 SLC25A11 F2 FES SLC25A1 PMC6235699__F2 NAD+ and sirtuins in retinal degenerative diseases: a look at future therapies NAMPT NMNAT1 NMNAT2 NMNAT3 PMC7323198__F2 Schematic summary of SARS‐CoV‐2 entry into host cells, replication, effect on host cells, and postulated effects of statins NLRP3 ACE2 IL1B TF SKP2 PMC5578165__F1 The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts ATM TOPBP1 BRCA2 RAD51 BRCA1 PMC5645057__F1 TGFB signaling pathway in prostate cancer cells SMAD2 SMAD6 SMAD4 TGFBR3 PMC4100143__F1 Diagram of CD4 T cell differentiation and immunomodulation by the AhR signaling pathway IL10 STAT1 AHR IL13 IL2 HEL-S-92n IL6 IL-21 IL4 TNF GATA3 FOXP3 PMC8458263__F2 RSR blockade stimulates innate anti-tumor immunity through the cGAS-STING pathway TBK1 CXCL10 IRF3 CCL5 IFNG PMC4794670__F4 Network of type I interferon response- and UPR-related genes IFIT3 BATF3 ATF7 CEBPE IFIT2 ATF2 TRIB3 FOSL2 CEBPG CEBPB BATF CEBPD ISG15 FOSB NMI JUN HLF CREB5 EGR1 FOS ATF3 CEBPA DDIT3 ISG20 DBP ASNS IFIT1 PMC6534082__F1 The mutIDH1 and mutIDH2 pathways and molecular mechanisms related to oncogenesis HEL-S-26 PLOD1 PLOD3 ME3 TET2 TET1 PLOD2 PMC7507458__F3 Links between lncRNAs and Hippo signalling cascade S100P HK2 PMC8603304__F1 Fungal cell wall components modulate our immune system NLRP3 TLR4 IL13 TNF MTOR IL1B PMC7507458__F2 Links between lncRNAs and Hippo signalling cascade RASSF1 PLK4 LATS1 TUG1 PMC9264363__F7 Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex UBL4A BAG6 SGTA ATP13A1 MAVS PMC7507458__F4 Reciprocal interaction between lncRNAs and Hippo cascade AMOT USP9X LATS1 LATS2 PMC7879558__F1 NHEJ and antiviral innate immunity TBK1 IRF7 IRF3 PMC1705513__F1 Inflammatory pathway in psoriasis NGF CCR6 CD34 CCL21 CD83 CCL4 CD69 IGF1 CCR10 VCAM1 CD2 CCL20 CCR7 CCL19 CCL27 TGFA CCL3 PMC8202900__F7 Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFB1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway SMAD2 KLF4 TGFB1 STAT3 PMC8807838__F9 Promotion of the inflammatory response in mid colon of complement component 3 knockout mice HEL-S-62p NLRP3 COX2 TNF SLC26A3 CFTR PMC7507458__F1 Molecular schematic of canonical Hippo signalling cascade in cancers LATS1 LATS2 PMC2168916__F7 Regulation of the AHR-XRE pathway by NRF2 AHR KEAP1 CYP1B1 PMC1361361__F7 Shp-1 mediates the anti-proliferative activity of TIMP-2 in human microvascular endothelial cells FGFR1 RECK CDK2 CDK4 PMC7267004__F1 Phagocytic receptors and modulating factors functioning in the phagocytosis as well as the antigen-presenting effect to naïve T cells in teleost phagocytic B cells TLR9 BCR CD22 CD80 PMC10341927__F10 Identification of Moesin (MSN) as a Potential Therapeutic Target for Colorectal Cancer via the Beta-Catenin-RUNX2 Axis HEL70 RUNX2 PMC6611515__F4 Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer CDK4 DBF4 ORC3 RBL1 CDC45 ORC2 PMC9005906__F1 Immunomodulation as a Protective Strategy in Chronic Otitis Media NLRP3 ATG16L1 NOD1 NLRP2 EGFR DAP MYD88 TNF IRF-1 NOD2 PMC2999475__F8 Summary of metabolomic findings in Hnf1a-null mice HNF1A PAH PMC3819728__F1 Unfolded protein response and its regulation on cell activities NRF1 ATF4 EIF2A PMC11491690__F1 HOXA9/MEIS1 and FBXO22 promotion of KMT2A‐r acute leukemia KMT2A HOXA9 FOXM1 MEIS1 BACH1 PMC4637163__F3 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer CD163 IL1B STAT3 PMC7911109__F1 Oxidative stress and antioxidants in the context of non-alcoholic fatty liver disease (NAFLD) ATF4 TG PMC3621409__F5 Evolution of mirrregulation EGF EGFR CIC PMC4637163__F2 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer CCL4 CCL2 STAT3 CCL3 PMC6172046__F7 Taurine Upregulated Gene 1 signaling circuit in osteosarcoma PI3 FOXM1 PIK3CA TUG1 PMC8898369__F8 TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer EGFR CD44 CCL5 PMC6524718__F4 The Nodal signaling cascade NODAL PITX2 LEFTY2 GDF1 PMC3448918__F8 Proposed mechanism for D10G-mediated suppression of NFKB-regulated gene expression TLR5 TLR4 PMC5951999__F7 Mechanism underlying how BYD exerts a cardioprotective effect MAPKAPK2 HEL-S-101 BCL2 BAX PMC4656338__F2 Signal transduction pathway in HIF-1A regulation VHL PTEN MTOR PMC8750610__F1 Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials BAG3 VCP STAT3 PMC3571113__F1 Six important signaling networks of osteoblast differentiation RUNX2 BMP2 ATF4 APC SOST FGF2 LRP5 ARHA DLX5 JUNB EPHB4 PMC5209547__F1 Quantification of thalamocortical dynamics using natural and artificial paired-pulse paradigm STIM1 STIM2 PMC5564849__F5 Integration of phytochemicals and phytotherapy into cancer precision medicine NDN POTEH ERF RB1 SFRS18 TMEM14A CRTAP MSL2 MPP3 RPF2 RALY ZNF91 RPUSD3 SUGP2 SHE SKP1 DLD ID1 CTHRC1 ZFP36L2 GTF3C2 CPN2 HLTF ELAC2 POLM PMC8692699__F2 Roles of long non-coding RNAs in lung cancer PHOX2A HOXA1 SP1 PDPK1 PMC3925027__F2 Cytokines and their receptors regulating peripheral B-cell survival HGF BCR PIM2 CD44 SYK CD74 TNLG7A TNFRSF13C PMC3130501__F1 Intrinsic and extrinsic apoptotic pathways BAD FADD BAX PMC5803919__F1 Systemic iron homeostasis ERFE BMP6 HAMP HEPH HFE TFR2 PMC4262241__F3 Network enrichment analysis of point mutations in genome TCGA-02-0014 PIK3R1 TBK1 MAPK9 NGF EGFR CSF3R DST CSMD3 PTEN TNK2 HEL-S-26 SYNE1 SLC2A2 NRAP PRKDC HEL-S-133P TMBIM4 USF1 PDGFRA MN1 MAPK7 NTRK1 VAV1 MAPK10 PRKD2 PDZD2 BRCA2 PMC11615452__F2 Therapeutic strategies targeting Wnt/Beta-catenin signaling SFRP4 DKK1 WIF1 PMC3075376__F1 Targeting GSK-3 family members in the heart: A very sharp double-edged sword APC MYC LRP5 PMC11615452__F1 Wnt signaling pathway NLK DAAM1 APC CCND1 RHO CDC42 PMC8699097__F1 Therapeutic Targets of KRAS in Colorectal Cancer RASSF1 GRB2 PMC5070770__F8 Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway LEF1 NOTCH1 TLE2 PMC5625838__F2A Innate and Adaptive Immune Responses in Chronic HCV infection TBK1 TRADD TRAF5 TRAF3 TRAF6 IRF3 TRAF2 MAVS PMC4799835__F3 TRAF6 in T lymphocyte activation and differentiation SMAD2 TGFBR1 TRAF6 MTOR GATA3 FOXP3 PMC10564417__F7 Schematic diagram showing the proposed mechanisms by which exosomal miR-486-5p derived from M2 macrophages regulates the osteogenic and adipogenic differentiation of BMMSCs RUNX2 SMAD2 SMAD4 PMC7175141__F1 Association between IDH1/2 mutation and NAD Production in Cancer NAPRT NAMPT NADK DHFR PMC10649670__F6 Central illustration SPARC SCG2 ITGB3 CCR3 ADAMTS9 VEGFD CXCL10 IL8RB CCL2 XBP1 BMP4 ADM2 CXCR3 CCL24 THBS1 PMC8072900__F3 Insulin Resistance in MAFLD TG IRS1 PMC7895515__F1 TGFB signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 ARHA PMC9490123__F1 DNA damage, inflammation and aging: Insights from mice CGAS ATM ATRIP SSB ATR CPD PMC5751354__F2 Molecular changes driving the Warburg effect PDC ENO1 PTEN HIF1A MTOR PMC5751354__F1 Glucose metabolism in cells PDC HEL-S-162eP PMC8131720__F8 Downregulation of miR-218 by porcine reproductive and respiratory syndrome virus facilitates viral replication via inhibition of type I interferon responses STAT1 SOCS3 IRF9 TYK2 JAK1 PMC8906930__F4 NRF2 in Bone Metabolism – Friend or Foe? MAFB CTSK NFATC1 MYC DCSTAMP TRAF6 CALCR RGS12 PMC4068281__F3 Signaling pathways and transcription factors supporting or affecting the barrier phenotype of CNS-ECs FYN NKX2-1 ERG LYN SHH SOX18 SP3 NQO1 PMC8906930__F1 NRF2 in Bone Metabolism – Friend or Foe? KEAP1 ADA RBX1 HMOX1 MAL PMC5777696__F1 S1P/S1P5pathway in mitotic regulation PLK1 SPHK1 SPNS2 PMC5466503__F4 Melanocyte differentiation LEF1 DCT TGFBR2 SMAD4 SOX10 SKI PAX3 PMC9344019__F2 Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology SELENON STT3A SELENOT SELENOF SELS SELENOM VCP RDH11 SELENOK PMC7696189__F7 Tyrosine kinase inhibitor (TKI)-based OFF-switch LCK ZAP70 CD19 PMC5466503__F2 Melanocyte activation integrated in the schematic view of the UV-induced pigmentation pathway in the normal skin HGF LIF DCT TYRP1 MC1R SOX9 PMC3227097__F6 Network of core pathways that mediate commitment of cells to the division cycle IKBKB BAD WASL MYC SRC SKI SKP2 PMC7447312__F7 Working model NR1i1 STAT4 PMC6795908__F5 Protein-protein network analysis using the DE genes (log2 fold > 2 and < 2) in the transcriptomic profiles of the cows with PTB-associated lesions versus the control group SPARC EREG PTGFR AASDH APOC3 PYGM TAF13 MOCS2 HPGD CUBN PIGM ALG10 HEL-S-133P SELE SCOC CTH PTGIR CDYL2 FOS UGT2B10 SLC10A2 LTB HBEGF CENPK PIGK NAGS CHST4 APOB ACADM AGL PMC10607693__F5 Fatty acid biosynthesis and TAG assembly pathway reconstruction HMFN0839 ACCS OAS1 DGAT1 GPAT4 GPAT2 DGAT2 PMC7404843__F1 Immune responses and immunotherapy strategy in SARS‐CoV‐2 infection IFNAR2 IFNAR1 ACE2 PMC7922062__F3 Glycan-lectin interactions within the breast cancer microenvironment modulate the phenotype of tumour-associated macrophages CCL24 CXCL5 CD163 GAL PMC2671631__F1 The L-arginine biosynthetic pathway and its association to proline and polyamine biosynthesis NAGK NAGS ASL PMC7827907__F1 Updated Insights on EGFR Signaling Pathways in Glioma NF1 EGFR SRC MTOR PMC8435626__F8 Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis APP CCND1 SYK PMC11540160__F1G SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway ESM1 VEGFA SRC MTOR SOX4 PMC99857__F9 The B(a)P-induced apoptotic signaling pathway, which is mediated by APIX PAK1 RAC1 CDC42 PMC6037111__F2 Consequences of hepatic fructose metabolism LPA ACLY PMC4667854__F2 Molecular events involving IRFs in immune responses TLR9 IRF7 IRF8 IRF9 TRAF6 IRAK4 MYD88 TLR3 STAT1 TLR7 TLR4 IRF-1 IRF4 IRF2 PMC5390468__F2 KEGG TGF-beta signalling pathway BAMBI FST NOG NOD1 INHA TOB1 SKA1 ARHA ZFYVE16 LTBP1 PMC4813201__F1 Relevant intracellular signal transduction pathways of local anesthetic-induced toxicity BAD FOS APC MYC FYN MDM2 GRB2 SRC SMO JUN FADD STAT3 CDC42 BAX PMC7452060__F1 circSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small-Cell Lung Cancer by Targeting the miR-520h/ABCG2 Pathway SETD3 ABCG2 PMC6135632__F10 The signaling pathway regulating RAB26-induced SRC degradation (a) Under normal physiological conditions, RAB26 interacts with ATG16L1, resulting in the induction of autophagy, which targets phosphorylated SRC for degradation ATG16L1 RAB26 SRC PMC3886269__F4 Inducible antioxidant defense regulated by Nrf2/Keap1 and the antioxidant response element KEAP1 HEL-S-64p PRX PMC11678013__F2 “Disease-Pathway-Target-Component-Drug” network CCNA2 F10 PLK1 DAO PIM2 ALK CA14 FLT4 MAPK3 GSK3B NRAS EIF4H CDK6 MMP3 MMP7 FGFR1 KDR NR1i1 MMP2 SREBF2 CHRM2 BCHE NOS2 CA4 ABCB1 CA7 NTRK2 ADK SNCA PTGIR CES2 MAP3K7 TNF SSTR4 EDNRA CNR2 PRKCB SLC6A3 NR1C2 PRKCH HEL-S-72p CA12 TERT FABP1 PTGER2 PGR CA13 ALOX15 ACHE SLC6A2 TOP2A EPHB4 ADAM17 PTPRS AHR APP FABP5 HSD17B3 CYP17A1 RORC KIT ADRA2C NR3C1 PTGES VHL NR3C2 HRH3 HSD17B1 CA9 HSD17B2 TACR2 AURKA CFTR PTPRF PTPRC IKBKB CTSG OGA ERBB2 CCNB2 LCK LYN ADA SYK SELP EPHA2 PPARG PLA2G2A SOAT2 ADORA2B METAP2 LGALS9 ALOX12 PRKCA PLA2G7 NLRP3 SCD SRC AXL HK2 NAMPT NADK HSD11B2 TAS2R31 NMUR2 CDK5 SSTR3 KDM4E PTPN13 SLC29A1 HRAS SLC28A3 SSTR2 HMGCR AURKB GLRA2 MMP14 DHCR7 FDFT1 CDK2 HEL-75 RORA MYLK ALDH2 PRKCE F2R BRAF NR3A2 EGFR NOX4 ESRRA HEL-S-104 INSR BTK SHBG CYP2C19 F2 NPY5R F3 LGALS7B IL2 CDK4 XDH ABCG2 CDC2 PTPN6 PRKDC JUN SQLE KCNA3 FBP1 FGF2 MMP9 PTGS2 PLK4 TNKS PARP1 FAAH HPSE NR1C1 TNKS2 IDO1 ALPL ADORA2A HEL111 MAP2K1 MMP12 PIM3 ADRA2A CDK5R1 MAP3K8 FLT3 MME PMC3174208__F1 Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke CTH SHMT1 CHDH NNMT PON1 TCN2 MTHFD1 AMD1 MTHFD2 HEL-S-61p MTR MAT1A MTRR DHFR TYMS TCN1 HEL-S-51e FOLR1 SLC19A1 PMC6545262__F2 The Notch pathway in human and mouse Th2 cell development and function GATA3 IFNG PMC8533628__F16 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 LPO PMC4573851__F2 The roles of FANCM family proteins in replication fork repair and crossover control BLM FANCM RMI1 SMC5 PMC4573851__F1 FANCM and partner proteins in coping with template lesions during DNA replication BLM FAAP24 ATRIP FANCM ATR PMC7896717__F3 Gene networks showing signatures of pervasive positive selection in Han Chinese and/or Japanese populations according to signet analysis performed on whole genome distribution of nSL scores and aimed at testing for polygenic adaptation NOX3 PLCB3 PRKCE PRKCZ ATF2 DGKE KLF2 GPAM PMC4114643__F2 Osteoclast differentiation and bone resorption by Rho GTPases NFATC2 ME2 NFATC1 TRAF6 RAC1 SBDS RHOU CDC42 PMC11592687__F3 Oxidative stress activates Hippo signaling pathway KEAP1 NF2 LATS1 LATS2 NEDD4 PMC11592687__F2 Hippo signaling pathway in ROS production LATS1 LATS2 FOXO1 PMC11592687__F1 Core components of the Hippo signaling pathway and their upstream regulators NF2 LATS1 RHO LATS2 PMC4535673__F3 Profiles of central and oxidative stress response metabolism pathways of K ACO2 ENO1 GPD2 HEL60 MDH2 PMC11772995__F6 Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway CORT CRH MTOR BDNF PMC9152203__F3 Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment MAP2K1 MAP2 CFB RBP4 SERPING1 APOH SERPINA3 FGL1 KRT10 PMC8533628__F13 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 LPO TUB PMC4695067__F6 Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2 EGF PMC8155723__F3 Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis STAT1 EBI3 STAT4 JAK1 PMC10376197__F4 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation TRPV4 SRC TRPM2 TRPM7 PMC10243030__F7 NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway CDH2 Nucb2 HMGCR PMC5618535__F2 PALB2 in the DNA damage repair PALB2 ATM BRCA2 RAD51 ATR DNA2 BRCA1 PMC8961363__F3 Floral Scents and Fruit Aromas: Functions, Compositions, Biosynthesis, and Regulation C9 C6 HEL-S-5 PMC8001967__F3 Mitochondrial regulation of ferroptosis CS FH LONP1 FXN SFXN2 ACSF2 RPL8 PMC2787666__F2 The complex network of protein–protein interactions of Ape1 VEGFA CASP9 CHEK1 PNKP FANCE PMS1 PMC5384343__F2 MTOR signaling pathway TSC2 TSC1 EGFR PTEN EIF4E RPS6 DEPTOR IRS1 RHEB PMC3260548__F1 The signaling cascade in response to the release of dsRNA from LRV particles, production of IFNB and secretion of proinflammatory cytokines and chemokines TLR7 TLR9 CXCL10 IRF3 MYD88 TLR3 PMC8348654__F1 Failure to Guard: Mitochondrial Protein Quality Control in Cancer PMC7828172__F2 ROR1 signaling SNAI1 BMI1 BCL2L1 MTOR ROR1 CCNE1 CCNB1 SRC CCND1 CDK4 RPS6 ABCB1 JUN WNT16 KIF26B FOS ARHA HEL-S-69p CASP3 DAAM1 RELA BCL2 HEL113 DOCK2 WNT5B CDC42 STAT3 PMC6595721__F2 Major mechanisms regulated by SUMOs and SUMOylation in kidney disease PTMS SMAD2 RELA VHL SMAD4 SKI BAX PMC4030106__F1 Roles of IL-21 and IRF4 in immune and metabolic regulation IL21R IRF4 FOXO1 STAT3 FOXP3 PMC2787666__F1 Base excision repair (BER) pathway FEN1 PARP1 UNG OGG1 PCNA MPG PMC7828172__F3 ROR2 signaling KIF26B FOS MMP9 SNAI2 ARHA MTOR HEL-S-69p CCND2 DAAM1 MMP2 SRC ROR2 HEL113 CDC2 RPS6 WNT5B JUN PCNA STAT3 CDC42 PMC4890876__F3 All of animal cells may be intrinsically programmed to self-destruct TRADD BCL2 TNF FADD PMC2667944__F1 Angiotensin converting enzyme 2 in the brain ACE2 PMC11575309__F7 DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer RBPJ MPO DLL4 PDIA4 ELANE PMC3348497__F1 Insulin-like growth factor (IGF)-1 signal transduction IGF1R IGF1 IRS1 PMC7226328__F4 Network analysis by Ingenuity Pathway Analysis (IPA) SFRP4 COL18A1 ANKRD22 NR3A2 SMAD2 VEGFA PCDHY SFRS3 NPTX1 CREBBP EP300 COL13A1 NRXN1 NR1C2 GRIA4 CXCL12 PMC10376197__F3 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation NFATC2 TRPC3 TRPM2 TRPA1 TRPV1 BAX PMC10376197__F2 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation ATF4 TRPM2 TRPM7 PMC3926887__F6 Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells CD14 NLK DAO MAX ECSIT BDNF PMC8533075__F10 Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK–AMPK–Sirt1-Associated Signaling Pathway in Mouse Models GPX3 TLR4 UNK SIRT1 BAX PMC9387421__F3 Zinc delays the progression of lung disease by affecting a variety of signaling pathways BAD MTOR IL1B BAX PMC3652739__F4 Microarray analysis also indicated an increase in Wnt signaling and cell cycle regulation in women DHFR MYC PCNA PMC7226441__F2 Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors APC CXCR4 CDH2 HIF1A STAT3 PMC9428319__F3 Pathomechanisms of bone loss in rheumatoid arthritis TH SOST DKK1 PMC5751940__F1 TumorMap framework and application to the analysis of the TCGA Pan-Cancer-12 Dataset PTPRC KIT PRKCB EGR2 NFATC1 FOS LCK Nbla10317 HIF1A ETS2 JUN PMC4753150__F4 Vitamin D and Calcium Regulation of Epidermal Wound Healing SOX21 MYCBP MSX1 CD44 WIF1 SOX7 SPRR1A CDC20 NR1i1 GPX2 SFRP1 MED1 AXIN2 TCF4 PMC3582304__F2 Therapeutic targets of the Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC8706120__F3 Roles of the Virome in Cancer RAC1 MAP2K6 PMC3582304__F1 Diagrammatic representation of the canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC5568901__F1 Antiviral mechanisms in mammalian cells: IFN-based antiviral system, including IFN expression pathway (AE) and IFN response pathway (AR); the intrinsic antiviral pathway (B); and the RNAi antiviral pathway (C) RNASEL CGAS RNASE1 TYK2 JAK1 TLR3 PMC9170969__F1 Antiviral immune response by African swine fever virus (ASFV) CGAS TLR4 STAT2 IRF9 IRF3 IFNGR2 TYK2 IFNAR2 RNF128 TLR3 MAVS IFNG PMC9170969__F3 Antiviral immune response by African swine fever virus (ASFV) TRADD CYLD ATF4 EIF2A BCL2 TRAF2 BAX PMC6338618__F7 Proposed model for the role of inhibition of BCLM by Ponatinib TNC ANGPTL4 PTGS2 JUN PMC8255676__F1 Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs VIT GPX4 FACL4 SLC7A11 HEL-S-64p SLC38A1 GLS PMC8590218__F4 Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure PDC CTSK TRAF3 LBP TRAF6 CD40 IRF3 RAC1 IRF-1 TLR3 TIRAP CD36 PMC2827926__F3 The refined scheme of the glyoxylate regeneration cycle, now termed ethylmalonyl-CoA pathway (right), and its connection to the serine cycle (left) GCK HPR PMC8093191__F1 miRNAs affect animal behavior related to MDD and BD by regulating the expression of genes involved in serotonergic neurotransmission and signaling pathways activated by glucocorticoids, BDNF, Wnt, and guidance cues APC HTR1A GSK3B STX1A FKBP5 ARHA PTEN BDNF DCC SGK1 SIRT1 PMC4335796__F1 NLR-mediated suppression of canonical and non-canonical NFKB signaling IRAK1 NLRP12 NLRX1 NLRP6 RELB TRAF6 CD40 MYD88 NLRC3 NOD2 PMC3312985__F4 Genes identified as part of the significant Para-ICA networks highlighted on a KEGG Alzheimer’s pathway diagram derived from the DAVID functional association tool CASP3 SNCA AFP BAD PC ATP6 HEL-S-11 TES LPL FADD PMC6895177__F8 Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors NLRP3 HMGB1 TXNIP IL1B PMC8387910__F1 Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review ADIPOR1 ADIPOR2 NR1C1 PMC7827308__F8 Simplified representation of intracellular pathways activated upon TLR activation and working mechanism of B18R TLR8 ADAR TLR7 IRF7 IRF3 MYD88 TLR3 PMC8841753__F2 Peptide-Based Vaccines for Tuberculosis IL6 CCL2 MYD88 TLR1 PMC11597542__F2 TLR and RLR signaling pathways and LNP effects IL10 TLR8 CXCL1 IL18 TLR7 TLR9 TRAF6 IRF3 IL6 MYD88 MAVS PMC8136793__F1 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication PRIMPOL RAD51 DDT PMC5940413__F5 Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer MAP3K1 GRB2 PIK3CA MTOR IRS1 PMC7338517__F6 Spermidine activates RIP1 deubiquitination to inhibit TNF-Alpha-induced NFKB/p65 signaling pathway in osteoarthritis MMP3 IL6 PMC2958230__F1 Effect of TBCD and its Regulatory Interactor Arl2 on Tubulin and Microtubule Integrity TBCE ARL2 TBCD TBCB TBCA TBCC PMC8136793__F3 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication PRIMPOL DDT PCNA PMC11641610__F3 Key signaling pathways involved in T cell senescence within the tumor microenvironment HLA-G ATM ZAP70 MTOR TERT PMC5195921__F8 G protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis FGF21 CYP27A1 CYP8B1 GHR CYP7B1 NR1C1 CYP7A1 CD36 PMC6704447__F11 Model for Rac1 involvement in TGFB1–driven renal fibrosis EGFR SMAD4 SRC PMC3973904__F1 Cholesterol metabolism, lipid rafts and autism spectrum disorders SQLE CYP46A1 LDLR ABCA1 BDNF HMGCR PMC5411428__F1 Proteostasis network and ALS TBK1 VAPB FIG4 ATF4 CHMP2B TMEM106B HEL-S-44 C9orf72 VCP XBP1 FUS PMC5579367__F1 Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis CGAS RIPK1 RIPK3 ZBP1 MLKL PMC9393224__F3 RNA binding proteins in osteoarthritis YTHDF1 QK3 TLR4 ZFP36 TAF15 NCL GNL3 BCL2 FGF18 FUS SOX9 PMC4772380__F10 HCV induces transforming growth factor B1 through activation of endoplasmic reticulum stress and the unfolded protein response ATF4 ATF3 PMC6523516__F7 Molecular mechanism through which high glucose (HG) concentration promotes proliferation and migration in colorectal cancer (CRC) cells IGF1R CCNB1 SRC PMC5053399__F1 Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening GRB2 PMC9162355__F10 1,2,3,6-Tetra-O-galoyl-Beta-D-glucose induced apoptosis signalling pathway in SGC7901 cells ATM APAF1 BAX PMC6996149__F4 Major cholesterol metabolic pathways in brain CYP27A1 CH25H CYP46A1 CYP7B1 HSD3B7 PMC6996149__F3 Regulatory factors of the acidic pathway of bile acid synthesis CYP27A1 CYP7B1 MAFG PMC6996149__F2 Acidic pathway of bile acid synthesis in metabolic regulations ABCG8 ABCG5 CYP7B1 PMC6996149__F1 Two major pathways of bile acid synthesis in mammalian liver CYP27A1 CH25H CYP46A1 CYP8B1 CYP7B1 CYP7A1 HSD3B7 PMC8212140__F3 Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance MYC CD44 HK2 PMC5789368__F1 Key players in the mammalian autophagy pathway discussed in this review ULK1 TSC1 TFEB ATG14 RHEB PMC3689841__F1 Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation GAB2 GRB2 SHE PTEN PMC6471273__F1 Biosynthetic pathway of ginsenosides according to MVK RB1 IPP PMC11787699__F1 YAP/TAZ in soluble biological signals in bone SMAD2 SMAD4 RHO LPA SMAD1 DKFZp781O1323 PMC5560141__F2 The EGFR signaling pathway involving CEMIP mediation EGF CEMIP SRC NRG1 PMC4825606__F1 Diagram of the roles and its signaling pathway of Cyclin B3 in oocyte meiosis CCNB3 APC CCNB1 PMC8042443__F7 A, schematic diagram showing two separate DGKζ signaling complexes, one for Rac1 activation (left) and one for RhoA activation (right) PAK1 MARCKS ARHA RAC1 LPA PMC6496019__F7 Schematic diagram proposed by the present research ATF4 EIF2A XBP1 PMC2789784__F2 Signaling pathway downstream of PI3K affect cell death and cell survival PI3 PDK2 MTOR PMC2536507__F2 Pathogen recognition systems TRAF3 TRAF6 IRF3 PMC4422111__F4 Kreb's cycle used to determine relative flux rates through acetyl-CoA synthetase (ACS), pyruvate dehydrogenase complex (PDH), pyruvate carboxylase (PC), and glutamate dehydrogenase (GDH) CS PC MAL PMC2330263__F2 Integration of Progesterone Receptor Action with Rapid Signaling Events in Breast Cancer Models GRB2 CCND1 SRC PMC5701508__F1 The crossroads of breast cancer progression: insights into the modulation of major signaling pathways FRK RELA EGFR HBEGF SP1 GPER PMC11747557__F6 Active ingredients of Radix Codonopsis exert anticancer effects in gastric and livercancer BAX PMC4397019__F7 Atypical Protein Kinase C Zeta: Potential Player in Cell Survival and Cell Migration of Ovarian Cancer PRKCA PRKCZ ITGB3 PMC11747557__F5 Active components of Radix Codonopsis promote lung cancer cell death and inhibitinvasion and metastasis BAD TRADD TRAF5 GRB2 CASP9 TRAF2 PMC12023346__F7 The effects of intraamniotic LPS exposure on the TRP metabolic pathways in the placenta and fetal brain IDO1 TPH1 KMO TPH2 IDO2 PMC59539__F2 Schematic model of Shh/Fgf10/Bmp4 signalling during lung branching morphogenesis FGF10 SHH SMO FGFR2 BMP4 PMC59539__F1 The Hh signalling pathway, based on what is known in flies SUFU SMO PMC11000535__F3 STAT3, EMT-TFs, miRNAs and lncRNAs form complex network to regulate EMT TWIST1 STAT3 PMC4846185__F7 ARF1 in mediating gefitinib sensitivity in breast cancer cells EGFR SRC ARF1 AXL PMC8216565__F10 Apoptosis signaling pathway AIP AGA ATM GEM ATF4 APP CASP2 CAD FADD MAPDA PMC12023346__F1 Tryptophan metabolic pathway ASMT HAAO HEL-S-90n KYNU DDC KMO AFMID AANAT PMC7169063__F1 IFN production pathway and different ways that the virus disrupts this pathway TBK1 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 PMC3060584__F6 ‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis MARCO HEL-S-11 AMBP PMC7169063__F2 IFN signaling pathway and different ways that the virus interferes with this pathway STAT2 IRF9 TYK2 PMC5354237__F2 Systemic damage responses of the fat body methionine metabolism (A) Methionine metabolism in Drosophila HEL-S-182mP PMC5675701__F8 Long non-coding RNA CRNDE acts as a ceRNA and promotes glioma malignancy by preventing miR-136-5p-mediated downregulation of Bcl-2 and Wnt2 MTOR PMC3035979__F2 Gene expression profile PLN TNC PMC4406277__F4 Pathway visualization SMAD4 CCNH RB1 CCND3 CCND2 PTTG2 EP300 ATM ATR PRKDC MPEG1 TGFB1 SKP2 CCNE2 PMC3559342__F4 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin FOXE3 SPIN1 HSPB3 GCDH MBD3 CSTF2 FGD2 CLN3 RNPS1 DHX38 SULT2B1 PHB2 KLHL20 HEMGN HNRNPR NRBP1 BARD1 CTDP1 DDX27 AP3D1 NBPF11 KLK10 HLA-DQA1 FIP1L1 MAST1 SMN1 PMC4542009__F1 Tumor Angiogenesis PIGF ERBB2 NRP1 EGFR VHL SRC NRP2 PMC3559342__F3 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin SALL4 RPLP2 CRHR2 GPR174 DNTT TP63 AVP CD200 FGF17 PRPF19 PMC3885718__F6 Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK IRS1 SIRT1 PMC4527020__F1 Location and signaling pathways of pattern recognition receptors TLR8 CD14 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR3 MAL PMC8235326__F2 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma BAD MCU BNIP3 TG S100A4 ORAI1 STIM1 PMC8235326__F1 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma SMDT1 NACA2 MCU ORAI1 STIM1 PMC4034727__F1 LncRNAs associated with the p53 pathway WRAP53 MDM2 PMC8458797__F1 Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway HEL-S-62p CD59 C6 PMC5701508__F2 PI3K signaling pathway.Notes: (A) Activation of receptor tyrosine kinase (RTK) by a ligand results in phosphorylation of the receptor and adaptor proteins MDM2 PTEN GAL MTOR PMC5701508__F5 Wnt pathways.Notes: (A) Planar cell polarity (PCP) Wnt pathway in “off” state, with no ligand bound to Fzd receptor leads to Beta-catenin proteasome degradation APC RYK RHO PMC5701508__F4 JAK–STAT signaling pathway.Notes: (A) Specific ligands bind to membrane receptors, leading to dimerization, which promotes JAK activation and transphosphorylation, which in turn phosphorylates STAT, prompting its dimerization IL10 STAT1 SOCS2 IL6 STAT3 PMC5981260__F2 Tumor suppressor molecules signaling MAF ATM GSK3B MDM2 PTEN ATR BRCA1 PMC8289457__F6 Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment BMPR2 GIG8 SMURF2 GSK3B SMAD6 ARHA RAC1 SMURF1 ID1 CLIC4 ID3 FKBP1A PMC5701508__F8 NFKB pathway.Notes: (A) The canonical pathway starts with binding of TNF to its receptor, activating the IKK complex, which phosphorylates IKBA, promoting its polyubiquitination and further proteasome-dependent degradation LTB RELB TNF LTBR PMC4684398__F6 Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKB and CREB Pathways and Negative ERK1/2 Pathway IRAK1 IRAK4 MYD88 PMC12111433__F6 This illustration depicts the pathways and key genes involved in the synthesis of chlorophyll and SGAs during the photoinduced greening of potato tubers UROD POR SSR2 RFWD2 PMC11954216__F5 Naturally occurring products that inhibit mTOR in BCSCs HEL-S-62p PTEN ME3 MTOR PMC7968835__F3 Towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe PTH1R LYN ADRA1A CACNA2D4 PMC11954216__F2 The mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials TSC2 HRG IGF1R SOX2 IGF1 SMAD2 SMURF2 EMP3 CD44 PROCR ST8SIA1 PMC11954216__F1 Cellular Mechanisms of mTOR in BCSCs: This schematic illustrates the multifaceted roles of mTOR in regulating cellular functions in BCSCs, with implications in metastasis, metabolism, autophagy, and ferroptosis ULK1 ARHA RAC1 MTOR SOX9 PMC11954216__F3 Targeting the PI3K/Akt/mTOR Pathway in BCSCs with synthetic drugs: This figure depicts synthetic inhibitors targeting the PI3K/Akt/mTOR pathway in BCSCs to reduce survival, proliferation, and resistance EGFR NOTCH1 MTOR PMC3670175__F1 Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans FAT2 FAT1 ACOX1 PMC9604078__F1 Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia CDKN1A MDM2 PTPN11 BCL2 BMI1 MCL1 FLT3 MTOR STAT3 TET2 PMC3186052__F6 Inhibition of prostate cancer cell proliferation through statin use, and its impact on the HMG-CoA pathway RHO RAC1 PMC4731498__F2 Placental mTOR as a nutrient sensing signaling pathway IGF1 EIF4E RPS6 PMC3744028__F9 Summary of the proposed role of Pak1 in mediating stretch-induced CTGF upregulation PAK1 EGFR TGFBR1 ARHA RAC1 PMC11933022__F4 TMAO effect on CKD: Three main pathways are depicted: TMAO activates macrophages by stimulating NLRP3 (NOD-like receptor protein 3) and stimulates T cell differentiation to produce multiple inflammatory factors, such as TNFA, IL-6, etc NLRP3 CRP SMAD4 TNF MTOR PMC8274167__F1 Metabolic regulators of enigmatic inflammasomes in autoimmune diseases and crosstalk with innate immune receptors NAIP NLRC4 NLRP1 NLRX1 NLRP6 TRAF6 GSDMD NLRP3 LTA NLRC3 AIM2 IL1B MAVS PMC9627342__F3 Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma HIF1A PMC5809401__F9 Schematic representation demonstrating the mechanism by which silibinin inhibits NSCLC metastasis via the EGFR/LOX signaling pathway EGF EGFR PMC5369987__F4 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis IRS4 SLC2A4 CREB5 PMC4720882__F1 Alcohol and HIV-related neuroinflammation and cytotoxicity contribute astrocyte cPLA2 activation into the limelight COX2 TNF IL1B CYP2E1 PMC5216465__F8 Four possible pathways (circles) by which CNP could activate CFTR GC CNP CFTR PMC5852597__F1 The Wnt signaling pathway that determines stem cell self-renewal ZNRF3 TCF3 RNF43 APC GPR49 PMC4310010__F1 Alterations in selected pathways in head and neck squamous cell cancers KEAP1 TP63 EGFR NFE2L2 PIK3CA CCND1 PTEN RB1 HRAS CDKN2A FBXW7 PMC4704690__F1 Controlling the burn and fueling the fire - defining the role for the alarmin IL-33 in alloimmunity AREG IL33 IFNG PMC5303602__F6 Schematic describing the effects and proposed response on TLR4 signaling pathway and inflammatory cytokines resulting from resveratrol treatment and HFD CD14 TLR4 TRAF6 IL1B PMC5369987__F5 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis PLN PDE3B BCR CAV3 NPY INS MCU CAV2 INSR PMC3597666__F5 Representation of the top canonical pathway ‘interferon signalling’ detected when simultaneously analysing the mRNA and miRNA data sets with IPA STAT1 IRF9 PIAS1 JAK1 IRF-1 PSMB8 IFITM1 IFNG BAX PMC6392285__F8 Calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation NLRP3 TNF IL1B PMC8293156__F2 Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation NONO GSK3B MYD88 TSC2 CASP3 TSC1 FYN HEL-S-11 GRIN2B CASP9 AMPH BDNF EPHA4 BAX PMC8226128__F3 Inflammasomes and Fibrosis NLRP3 HMGB1 KEAP1 TXNIP PMC4333878__F1 Apoptotic cell death pathways and (b) inhibition of the apoptosis signalling pathway STAT1 FOXO1 STAT3 BAX PMC9334798__F1 Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends? GPX4 LPCAT3 FACL4 SLC7A11 GLS2 ATF3 PTEN POR TSC2 NF2 SLC3A2 DHODH HILPDA PMC4394621__F7 Kinase targets and inhibitors TRADD EGFR GRB2 PTEN MTOR TRAF2 PMC8237755__F2 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System RICTOR IGF1 SRC EIF4B IRS1 PMC8237755__F1 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System EGF RICTOR MYC GRB2 CCND1 SRC GAL PMC7281461__F2 Primary pancreatic cancer recruits fibroblasts to become cancer associated fibroblasts (CAFs) DKK3 FAP HEL-S-70p ANXA6 PMC6460433__F7 Model for regulation of antiviral innate immunity by BA metabolism CYP27A1 SLCO2B1 SRC IRF3 PMC4935551__F2 Role of chaperone-mediated autophagy in metabolism CS DGAT2 HEL-S-30 FBP1 ADFP APOC1 HEL-S-53e HEL-S-32 HEL-S-61p HEL-S-26 APOOL FH GPD2 PMC8343065__F1 Cell Cycle Commitment and the Origins of Cell Cycle Variability CDK2 MYC CDK4 CDK6 PMC7602737__F5 Suggested mechanisms of action of fenugreek on milk synthesis and secretion LALBA IGF1 ACADS CPT1A OXTR GHR LPL OXT CSN2 MTOR INSR FASN PMC5288595__F5 Serum markers that change in response to treatment CNTF RETN IGFBP1 NR3C1 IGFBP2 IFNA2 SERPINA1 NCAM1 TNF CD36 PMC8954493__F7 Gene Expression over Time during Cell Transformation Due to Non-Genotoxic Carcinogen Treatment of Bhas 42 Cells SQLE SHMT1 IDI1 MTHFD1 IPP MTHFD2 PHGDH ACAT2 MVD PSAT1 FDFT1 DHFR TYMS PSPH PMC8795407__F1 The Hippo pathway signalling cascade and its stimuli TEAD3 NF2 VGLL4 TEAD4 LATS1 MOB1A MOBKL1A LATS2 BMP4 TEAD2 PMC5288595__F2 Steroid-specific protein markers MFGE8 BIRC5 FGF2 RTN4 NR3C1 INS AFM SPARCL1 TNF GCG APOB GHR IBSP TGFBR3 DIPLA1 APOE PMC3317229__F4 P38 signalling cascade (adapted from http://www.sabiosciences.com/) CD14 MAPKAPK2 MAX SRC JUND MAPKAPK3 JUNB OSM PMC3317229__F3 JNK signalling pathway (adapted from http://www.sabiosciences.com/) GRB2 RAC1 CDC42 PMC5430417__F6 Mechanisms involved in the antagonist effect of sinapic acid against UVA-induced attenuation of stemness and differentiation properties of stem cells KLF2 CEBPA PMC11592827__F6 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study NR3A2 EGFR GSK3B HEL-S-104 NQO1 PDPK1 INSR STAT1 MMP3 RARB ERBB4 FGFR1 NR1i1 MMP2 MDM2 SRC IL2 FABP5 NR1H3 APOA2 MMP9 GSTM1 RXRA HEL-S-22 CASP3 GRB2 JAK3 CDC42 PMC7961376__F1 Molecular pathways of novel emerging targets in NSCLC and agents in clinical development HGF NGF NTRK1 NTRK3 PSPN PTEN RHO MTOR ARTN NRTN CDK6 RET GDNF CDK4 NTRK2 PMC8674491__F3 Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment AHR CSK LCK TNF MTOR TG HEL-S-133P PMC9052532__F3 Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies TH PNP IFNG PMC11953061__F3 Protein–protein interaction (PPI) networks of reproducible and differentially expressed proteins (RDEPs) were generated via the STRING database PRKAA1 PARP1 MTOR SYT1 TUBA1A CDKN1A MMP2 CXCR4 RELA CCND1 HEL113 PTPN6 PPARG PCNA CYCS BAX PMC5458753__F1 ZIKV genome structure and signaling transductions underlying ZIKV infection STAT2 TYRO3 MTOR AXL TLR3 PMC8052633__F3 Interplay between p62-mediated autophagy and the cGAS-STING-mediated DNA sensing pathway TBK1 CGAS ULK1 ATM IRF3 MTOR PMC7026265__F4 Pharmacological strategies to control endoplasmic reticulum (ER) stress in diseases ATF4 EIF2A CNPY2 XBP1 PMC7053098__F5 Cisplatin-induced P53 signaling pathway genes are differentially expressed between Sirt2-deficient and Sirt2-proficient cells CASP3 TSC2 SIAH1 ATM CDK2 MYC CASP9 UST PTEN ATR RFWD2 PMC7096376__F2 NAD biosynthetic pathways NAPRT NAMPT HEL-S-90n NRK PMC7096376__F1 Intra/extra NAD interconnections and NAD-metabolizing enzymes NAMPT ENPP1 PMC7026265__F1 Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities ATF4 EIF2A CNPY2 TRAF2 XBP1 PMC4843516__F2 Neuroendocrine pathways regulate stress tolerance in C SGK1 NCR1 NCR2 PMC8052633__F2 Interplay between autophagy and DDR RNF168 ULK1 ATM BCL2 RAD51 PARP1 BNIP3 MTOR BRCA1 PMC9163742__F3 Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases ARID2 TGFBI PMC8859442__F2 Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications MSC NOX4 PMC8192769__F5 Schematic diagram of the effects of fadraciclib at 4 h BAD CDC2 DIABLO HTRA2 BAX PMC8001868__F5 Summary of some of the effects of allicin on eukaryotic cells KEAP1 YAP1 IMPACT PMC10343400__F6 Glycosides and UC-related receptors AND transcriptional regulation NLRP3 TLR4 NQO1 PMC8453895__F3 Contribution of irisin pathway in protective effects of mandarin juice (Citrus reticulata Blanco) on metabolic syndrome in rats fed with high fat diet UCP1 PPARG FNDC5 PMC5894358__F11 The schematic diagram of potential molecular mechanisms of anti-inflammation effects of recombinant human Netrin-1 (rh-NTN-1) through UNC5B/PPARG/NFKB signaling pathway after SAH NTN1 MPO UNC5B PMC6746704__F8 Elevated FAM83A expression in pancreatic cancers is driven by a MEK/ERK-JUNB-driven feed-forward signalling loop EGR1 FAM83A FOSB JUNB PMC134648__F8 Role of Axin2 in Wnt signal transduction APC GSK3B TEF AXIN2 PMC2860204__F4 Integrin signalling at focal adhesions FYN GAB2 GRB2 SRC CRK PMC9603070__F10 Melatonin Enhances Drought Tolerance in Rice Seedlings by Modulating Antioxidant Systems, Osmoregulation, and Corresponding Gene Expression ASMT PMC4221543__F1 The MAPK/ERK pathway PI3 EGFR SRC MTOR PMC8750957__F2 TNF-Induced Osteoclast Differentiation RELA TRAF3 RELB TRAF6 TRAF2 PMC8307807__F3 Wnt Signaling by FOX Transcription Factors in Cancer FOXB2 FOXO3A FOXM1 PMC3038089__F2 Biological consequences of methylation on Rho-RhoGDI interaction ICMT RHO OTP PMC3382540__F1 ERK signaling pathway controls T-cell activation and anergy ZAP70 PMC8307807__F1 Wnt Signaling by FOX Transcription Factors in Cancer LRP5 LRP6 PMC6292965__F9 DT-13 promoted mitochondrial apoptosis and inhibited metastasis via suppressing PI3K/Akt pathway CASP3 BAD CASP9 BAX PMC3170456__F1 Autophagy in Cancer: Therapeutic Implications TSC2 PML TSC1 ATG12 ATG3 LAMP2 BCL2 PTEN ATG10 MTOR DKFZp686F0183 MLST8 PMC4333878__F2 EBV interaction with the Bcl family CD40 CD74 PMC7665122__F2 Signaling pathway induced by aPL TLR4 TRAF6 MYD88 TF PMC9686959__F2 Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities GPX4 LPCAT3 FACL4 SLC3A2 PMC9542548__F5 Mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo ERFE EPO HAMP TES FTL ALAS2 PMC3187864__F6 Axon viability depends on coordinated endocytic trafficking and signaling NGF KIF3A RILP PMC3491533__F8 Diagrammatic presentation shows how Notch and TGFB signaling pathway involved at each pathogenic stage of HBV infection FOXP3 PMC8036441__F5 Quercetin apoptotic mechanism via death ligand and mitochondrial membrane COX2 BAD BAX PMC6323527__F2 Variety of factors control Tn cell survival and metabolic pathway engagement after T cell activation HEL-S-62p GCLC CPT1A SLC7A11 HEL-S-51e PARG PPARG PMC6323527__F1 Core metabolic pathways for T cell survival, activation, differentiation, and function CPT1A SRC PMC5757446__F2 Current and proposed molecular mechanisms augmenting myogenic reactivity in subarachnoid hemorrhage opn ARHA SPHK1 TNF CFTR PMC3893574__F1 MiRNAs involved in the regulation of the IGF-1/Akt pathway and myostatin signaling IGF1R IGF1 PTEN MTOR IRS1 PMC4067963__F10 Model of Sox9, Sox10 and FGF function during lacrimal gland branching morphogenesis FGF10 SOX10 COL2A1 COL9A1 FGFR2 SOX9 PMC11743681__F1 Cellular and Molecular mechanisms regulating Neural Crest (NC) cell migration and polarity CXCR4 PTK7 ARHA RAC1 CNN2 CDC42 TRIO PMC8925056__F8 TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes PINK1 CXCL10 CCL22 TSLP CCL1 SDHA PMC3547893__F1 Interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility FPR1 SP1 ADRBK1 PMC7363821__F1 High temperature- and cortisol-induced changes in gene expression ME1 PLTP UCP1 NR1C1 PMC5550896__F1 TGFB family member signaling and its target in CRC BMPR2 ACVR2B ACVR2A BMPR1A ACVR1C TGFBR1 ACVR1B TGFBR2 SMAD1 DKFZp781O1323 PMC3710993__F1 Energy status of cells modulating cell signaling and mitochondrial function TSC1 GSK3B PTEN RHEB PMC8584016__F1 Systemic Review: Ozone: A Potential New Chemotherapy KEAP1 NQO1 PMC3141289__F1 Signaling pathway leading to signal transducer and activator of transcription (STAT)-3 activation (see text for definitions of abbreviations) CNTF EGF EGFR TGFA STAT3 PMC2646065__F8 Proposed model involving GSK-3 inhibition and the mTOR pathway to stimulate human Beta-cell growth and proliferation TSC1 IGF1 EIF4E MTOR IRS1 RHEB PMC3923157__F2 Tumor necrosis factorA and its osteoblastogenesis paradoxical effects RUNX2 SOST LRP5 LRP6 CERK PMC8602361__F1 Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease NLRP3 TLR4 PMC2819219__F7 Caspase Mediated Cleavage, IAP Binding and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NFKB Signaling DAP FADD PMC7886986__F1 Major immune cell checkpoints and associated signaling pathways TRAF5 APC ZAP70 CD48 TRAF6 BTLA CD80 LAG3 TRAF2 PMC7963908__F9 TNBS-induced activation of the toll-like receptor (TLR) 4 signal transduction signaling cascade, which leads to the activation of canonical NF-kB pathway IL16 TLR4 TNF PMC8316766__F1 Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone UGT1A4 UGT2B10 ABCB1 CYP1A2 PMC5727528__F3 Metabolic interventions predicted by the OptForce algorithm RLIM IPP RPE PMC5319818__F1 Gasotransmitters in cancer: from pathophysiology to experimental therapy COX2 TIMP1 FGF2 HIF1A PMC2572128__F1 Simplified model of translation initiation EFS EIF5B ELF5 ELF3 EIF4H EIF4E EIF4B EIF5 PMC8015171__F9 Basal cell-fibroblast interaction in IPF EDN1 ACTA2 LPA COL1A1 TGFB1 PMC7247570__F3 Cross-talk of the mitogen-activated protein kinase (MAPK)/ERK signaling pathway and mechanism of cell death induction through the ERK-Hippo interplay CASP3 EGFR GSK3B BCL2 MCL1 PMC6435939__F1 Proposed platelet-endothelial cell adhesion molecule-1 (PECAM1) and Src signaling pathway activation in ARDS and in ventilator-induced lung injury SRC PECAM1 STAT3 PMC8467684__F6 Identification and Characterization of Novel circRNAs Involved in Muscle Growth of Blunt Snout Bream (Megalobrama amblycephala) CASP3 TSC2 PIK3R1 BAD TSC1 EGFR APIP CASP9 AIRE PTEN MTOR RHEB PMC7289300__F5 LncRNA-mRNA expression correlation network (co-expression network) analysis of core mRNAs and their correlated lncRNAs AIP SNRPD2 DUSP14 PRSS22 MYC MAGED2 PMC12063130__F2 Targets of JNK/p38 MAPK signaling pathway in OC drug resistance CCNB1 CCND1 CDK4 CDC2 TNF ABCB1 PMC7073664__F7 Putative fatty acid synthase pathway of Thraustochytriidae sp TH DES CP PMC3328211__F2 Arterial-venous and lymphatic specification in vertebrate embryo FOXC1 HEY2 NRP1 SOX18 FOXC2 SOX17 SOX7 EPHB4 NRP2 PMC3740204__F2 Angiogenesis pathway of FAK, EZH2 and Dll4/Notch in cancer-associated endothelial cells NOTCH4 VEGFA NOTCH1 SRC EZH2 E2F3 VASH1 PMC7697807__F1 Activation and negative regulation of NFKB and STAT3 IL6 TNF STAT3 PMC12133565__F6 Loss of Hdac1 hyperactivates oncogenic transcription PDE1C PLCL1 JDP2 ALK ADCY1 CAMK1G VEGFA TNK2 NOS2 CACNA1C PMC3941008__F1 Complement activation pathways HEL-S-62p FH PMC9485881__F3 Advances in the superhydrophilicity-modified titanium surfaces with antibacterial and pro-osteogenesis properties: A review TH CD163 CD84 IL1B PMC3832913__F3 Alternative pathway CD59 C9 CS THBD CFH C6 CFI PMC8139965__F7 Hypothetical schema of the effect of IL-26 on EGFR-TKI resistance EGF EPHA3 ATF4 EGFR ATF3 CXCL2 DDIT3 PMC4670900__F4 The proposed pathway for energy production, based on the KEGG-associated proteins found in the proteome of L PTS HPR SDHA HEL-S-162eP PMC4606066__F1 Expression and function of the insulin/IGF system in normal and colorectal cancer cells IGF1 IGF2 GSK3B MTOR IRS1 IGF2R PMC6567810__F7 Construction of a regulatory network for integrated miRNA-target genes CREB3L2 PPARGC1A RFX3 TGFBR1 ZKSCAN1 NR2C2 NR3C2 NCOA1 SP1 ZNF609 STAT3 TET1 PMC8324686__F2 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) PCSK9 LDLR PMC9437888__F2 Developing a CRISPR‐assisted base‐editing system for genome engineering of Pseudomonas chlororaphis HPD TG GCG PMC9204280__F10 FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis RCCD1 NPM1 PSMG1 LRPPRC EEF1E1 GINS1 ATAD2 BYSL POLA1 CDC123 LSM7 SRPK1 PAICS DKC1 HEL-S-70p GINS2 CAD GMNN RPF2 SSRP1 NPM3 MIS18A PFAS FBL MTIF2 RUVBL1 MDC1 MCM7 SNRPC DSCC1 CDC45 RFC3 RFC4 CPSF3 SUV39H2 C7orf11 WDR43 CENPN PDCD2L LSM2 BRIX1 PPIL1 SKP2 CENPV TRIP13 RPP40 CCDC86 PMC8324686__F1 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) VPS35 NPC1 RAB8A RNF26 LDLR NPC2 RAB24 PMC4128878__F1 Alpha-catenin APC PMC11898721__F11 QSAR-Based Drug Repurposing and RNA-Seq Metabolic Networks Highlight Treatment Opportunities for Hepatocellular Carcinoma Through Pyrimidine Starvation ENTPD8 CMPK2 DTYMK TYMS DUT DHODH CMPK1 ENTPD1 CTPS2 PMC7404279__F4 Depiction of a cancer cell motility and migration signaling network model that includes DEGs identified by RNA-seq analysis () as displaying upregulated genes in H GRB2 SRC RHO CDC42 PMC11024251__F2 Signaling pathway of EGF EGF EGFR GRB2 CBL PMC9020058__F7 De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet PLK1 SFN BIRC5 PPP2R2C CACNA1C ITGA2 GNG4 MAPK12 opn SRC COL2A1 PTTG1 KRT20 SOX2 GPC3 DUSP9 THBS4 PLCB1 CDC20 GABBR2 WNT3A CCNB2 KCNK9 IBSP ITGAV KRT12 CTNNA2 TERT PMC7738817__F5 miR-133a involves in EGFR/c-Myc/P53 axis and the associated signaling pathway CXCR4 EGFR ARHA CXCL12 PMC9248048__F3 Footprint of Kynurenine Pathway in Cardiovascular Diseases CXCL1 APOB AHR HMGCR PMC2661541__F1 Transforming growth factor-beta (TGFB) signaling pathway SMAD2 SMAD4 PMC8064165__F8 Dual activation of Hedgehog and Wnt/Beta-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer SUFU LRP5 LRP6 SMO PMC3236571__F7 Resistance mechanisms in the TRAIL signaling pathway BCL2 FADD BAX PMC3917155__F4 Inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity APRT GIN1 MTOR PMC7670868__F1 Outline of major DNA DSB repair pathway and its relationship with host anti-tumor immune response ATM CHKA CDK2 CDC2 ATR IRF-1 PMC11020452__F4 Regulatory mechanism of tsRNAs in cancers TSC2 TSC1 APC JAG2 MDM2 EEF1A1 FOXK1 PTEN TF PMC4693238__F3 Intracellular detection of viral RNA by PRRs and activation of the innate immune response TBK1 ADAR TLR7 IRF7 IRF9 IRF3 MYD88 IL1B TLR3 MAVS PMC11000312__F3 Mechanisms underlying SALL4 regulation and function in colorectal cancer SALL4 PMC6814794__F9 KEGG pathway enrichment analysis of methylated regions– TRADD FOS PTGS2 TRAF3 IL6 TNF CASP3 MMP14 CSA2 TRAF2 CA12 JUN FADD MLKL AGL SELE ITCH PMC11000312__F2 Mechanisms underlying SALL4 regulation and function in gastric cancer SALL4 GC CD44 EZH2 TGFBI HK2 STAT3 PMC9508095__F9 Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin A7 is counteracted by TBK1-p62 axis-mediated autophagy TBK1 TRAF3 IRF3 PMC11000312__F1 Mechanisms underlying SALL4 regulation and function in esophageal cancer NOTCH2 SALL4 MAML1 SOX2 WNT3A NRBP1 MEIS1 NOTCH1 NOTCH3 PMC3607645__F5 Epidermis model pathways WNK1 OSR1 PMC11000312__F4 Mechanisms underlying SALL4 regulation and function in liver cancer SALL4 EPCAM KRT19 CD44 PTEN TNF PMC5406704__F1 The phosphatidylinositol-3-kinase (PI3K) pathway CXCR4 PTEN MTOR BAX PMC4053166__F1 Meet the terminator: the phosphatase PP2A puts brakes on IRF-3 activation TBK1 IRF3 BAX PMC4891110__F8 Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate PCK1 FBP1 ENO1 ENO2 tal-1 PMC8217088__F6 Lipid metabolic alterations induced by EPHB2 deficiency in prostate cancer DGAT1 DGAT2 EPHB2 PMC6689672__F3 Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung TH CD14 CDA CD33 CXCR5 FUT4 CXCL13 CXCR3 ITGAM CXCL16 AHR CXCR4 CCL20 GATA3 PMC4187736__F11 Model recapitulating the role played by HUWE1 in regulating Shoc2-supported ERK1/2 activity EGF HUWE1 SHOC2 PMC3896945__F1 Pharmacological approaches to restore mitochondrial function NAMPT NCOR1 NRF1 MTOR TFAM NR1C1 RXRA PMC8983858__F2 Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis TRPV4 HEL-S-11 VWF KLF2 RHO MTOR PECAM1 PMC8642070__F4 Bicuspid Aortic Valve: Genetic and Clinical Insights SMARCA4 JARID2 PMC9202500__F6 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses TBK1 IFNK IRF9 EGFR TRAF3 IRF3 IFNAR1 KPNA1 NOD2 MAVS PMC5187897__F1 Intrinsic and extrinsic apoptosis pathways in mammalian cells TRADD APAF1 FADD PMC9202500__F5 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses ATF4 XBP1 BAX PMC9202500__F4 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses ULK1 IGF1R MTOR DKFZp686F0183 PMC4614139__F1 Mutations in PI3K, PTEN and AKT have dual effects on neuronal development leading to the formation of HMEG and FCD TSC2 TSC1 PTEN RHEB PMC5447936__F2 AUTS2-Rac signaling pathways in neuronal migration and neuritogenesis AUTS2 ELMO2 RAC1 CP PMC4022194__F2 Signalling pathways that were altered in the high serum group CDC20 E2F7 POLE RPRM KNTC2 CCNB2 APC SLK DLGAP5 AURKA SPC25 PMC9267958__F5 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways EGF TLR4 GRB2 PMC9267958__F4 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways TLR4 IL6 MYD88 PMC9267958__F3 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways STAT1 SRC IFNG STAT3 PMC11654293__F8 Expression levels of differentially expressed genes related to galactose, starch and sucrose metabolism MGAM LALBA TREH GLA PMC6742699__F2 Complement-platelet interactions that can facilitate an inflammatory response that favors atheroma formation HEL-S-62p PF4 FH VWF C4A CP PMC4062840__F2 Regulation of Akt phosphorylation PHLPP2 PTEN PHLPP1 PMC11050257__F3 Representation of the diversity of the AP-1 family of TF PAK1 ATF2 GRB2 JUNB MEF2C CDC42 BATF PMC9375713__F2 NLRP12 in Innate Immunity and Inflammation IRAK1 NLRP12 TRAF3 TRAF6 IRF3 MYD88 TNF TRIM25 TLR3 TLR7 TLR4 IL1B MAVS PMC9556725__F1 Neurobiology of pain and facial movements in rodents: Clinical applications and current research ASIC3 BDNF TRPV1 PMC11050257__F5 MYC protein and its signaling pathway MAX APC GSK3B MYC PMC7390965__F1 Differences between the UPR in mammalian and plant cells EIF2A XBP1 PMC3136489__F7 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood STAT2 IFITM2 IL6 IFITM1 MX2 MX1 IFNG STAT1 ISG15 GBP1 ISG20 STAT4 GBP2 IFNA10 PIAS1 IFI30 IFIH1 IRF-1 PSMB8 IFI6 IFIT1 PMC11050257__F2 Androgen receptor structure and signaling pathway in PCa SHBG TBP TMPRSS2 PMC10570508__F2 PITX1 acts as a core gene that regulates the p53 signaling pathway PIN1 SF1 PITX1 TFDP1 PMC8224422__F2 Synthetic Formatotrophs for One‐Carbon Biorefinery LTA HAL F2 GPT GAL PMC9065266__F3 Inflammasomes in Cancer Progression and Anti-Tumor Immunity NLRP3 NLRC4 NLRP6 TNF GSDMC AIM2 GSDMD IFNG PMC3294376__F4 O-linked N-acetylglucosamine (O-GlcNAc) is a nutrient sensor and underlies glucose toxicity OGA OGT INS CRTC2 SP1 IRS1 PLCB1 PMC9065266__F2 Inflammasomes in Cancer Progression and Anti-Tumor Immunity NLRP3 NLRC4 NLRP1 SI NLRP6 IL8RB TSLP AIM2 PMC9065266__F1 Inflammasomes in Cancer Progression and Anti-Tumor Immunity NAIP NLRC4 LBR NLRP1 NLRP12 NLRP2 NLRP6 IRF3 MYD88 NLRP7 NLRP9 GSDMD NLRP3 AIM2 IL1B PMC5594744__F3 The MUST complex (MAGEL2-USP7-TRIM27) is important for the retromer-mediated endosomal protein recycling pathway VPS35 TRIM27 PMC4020352__F1 Noncanonical transforming growth factor B signaling in scleroderma fibrosis SMAD2 SRC SMAD1 CTGF PMC4020352__F3 Noncanonical transforming growth factor B signaling in scleroderma fibrosis SMAD2 SMAD4 PTEN PMC9243368__F1 Advancements in prevention and intervention of sensorineural hearing loss HES5 ATOH1 JAG2 GSK3B HES1 PMC3671705__F1 Targeted therapies for head and neck cancer IGF1R EGFR MTOR PMC10224264__F3 Hypothesized mechanism of coronavirus-induced neuronal damage via oxidative stress and mitochondria dysfunction ACE2 IL1B TMPRSS2 PMC11922887__F1 Potential mechanisms of HDAC1 and HDAC2 in microglial activation and/or neuropathic pain TNC TLR4 HDAC3 HDAC2 MYD88 SP1 HDAC1 PMC5960217__F1 Schematic depiction of the canonical and non-canonical Wnt pathways WNT3A APC WNT1 ARHA RYK CDC42 PMC4340386__F1 Simplified diagram of the sphingolipid biosynthesis pathway in S SIM1 ORM1 SIM2 HEL-S-5 PMC5979467__F2 Role of survivin in caspase-mediated apoptosis BAD CS DIABLO FADD PMC5979467__F3 Survivin regulation IGF1R CS EGFR MDM2 MTOR PMC5405063__F1 Regulation of translation initiation by the (TOR) pathway, eIF4E activity and eIF2A phosphorylation in response to developmental and environmental cues in plants CD2 EIF2A EIF3S3 EIF4E GCN1 PMC12180219__S1 Bionic bearing-inspired lubricating microspheres characterized by immunomodulatory for osteoarthritis treatment MMP3 ADAMTS4 PLG MMP9 ACAN TNF SOX9 PMC3814599__F1 The nuclear pore complex (NPC) and classical nuclear import pathway NUP214 NUP160 TPR NUP210 NUP62 NUP153 RANBP1 NUP133 NUP85 NUP98 RAN NUP107 NUP155 PMC8143540__F2 Oxidative Stress in Cancer Cell Metabolism BAD SRC PTEN HIF1A MTOR BAX PMC11922887__F3 Potential mechanisms of Sirt1 in microglial activation and/or neuropathic pain NLRP3 HMGB1 TLR4 SHH ARC MYD88 SIRT1 PMC8291349__F4 Regulation of the CYP7A1 gene DKFZp666G145 HGF FGFR4 PROX1 TNF CYP7A1 RXRA NR1i1 HNF4A FGF19 SIRT1 IL1B MAFG PMC11922887__F2 Potential mechanisms of HDAC3 in microglial activation and/or neuropathic pain STAT1 CGAS HDAC3 LRRK2 AIM2 SIRT1 TET2 PMC10224264__F5 Anti-apoptotic and anti-inflammatory effects of Ginkgo biloba extract (EGb) and its constituents STAT1 GSK3B CDK5 STAT3 PMC8291349__F1 Bile acid and oxysterol synthesis in the liver and other tissues CYP27A1 GCA CYP46A1 CYP8B1 CYP3A4 CYP7B1 BAAT CYP7A1 PMC7538629__F5 Changes of FAs metabolism in hamster liver of HFD group (A) and HFD+ADT group (B) MFN1 FADS2 FADS1 CD36 PMC6514289__F1 Metabolic pathway of vicagrel and clopidogrel in humans CYP2B6 CES2 CYP2C9 CYP2C19 AADAC CYP1A2 PMC8143540__F3 Oxidative Stress in Cancer Cell Metabolism BAD TRAF2 FADD BAX PMC4261550__F1 Neuroprotective functions of resveratrol in AD pathogenesis STAT1 GPX1 NOX4 STAT3 BAX PMC4951507__F4 ICL repair FANCD2 BRCA2 SLX4 RAD51 FANCM UHRF1 ATR BRCA1 PMC10994423__F5 Advances in the application of traditional Chinese medicine during the COVID-19 recovery period: A review STAT1 RIPK1 ELK3 GRB2 TRAF2 TAB3 PMC4951507__F3 Main posttranslational modification events involved in the activation of response to ICLs FANCD2 ATM SENP6 PIAS1 UBE2T FANCL RNF4 ATR USP1 PMC6523687__F1 Epidermal growth factor receptor (EGFR)/EGFR variant III (EGFRvIII)-dependent biological signaling pathways EGFR PTEN MTOR PMC7346972__F1 Insulin growth factor pathway and its relationship to intracellular signaling molecules BAD IGF1R MTOR PMC6376270__F5 Interleukin‐1B (IL‐1B) was up‐regulated in nerve regeneration EGF NGF TRADD MYD88 TNFRSF11A PTS COX2 GADD45B BTK TLR4 BCR ATM BASH IL1B CD14 PTGS2 LTB CXCL2 TRIM25 LTA BIK LCK LBP LYN CD40 SYK LAT TIRAP PMC5960217__F3 Wnt signaling in hematopoietic stem cells and early B cell development PREB FZD9 CD24 PMC7348145__F8 WDFY3‐AS2 contributes to the suppression of cell proliferation and invasion by manipulating miR‐2355‐5p/SOCS2 signalling axis SOCS2 PMC5960217__F4 Wnt signaling pathway and multiple myeloma IGF1 WNT16 WNT4 CD44 IL6 DKK1 PMC2694829__F6 HIV-1 TAT T cell receptor signaling pathway HEL-S-11 LAT PMC9300700__F4 Broad view of the role of Galectin-3 in microglia-associated neurodegenerative diseases NLRP3 TLR4 MERTK DKFZp686L24211 GPNMB APOE CD68 PMC4990112__F3 RNF8 and RNF168 promote the accumulation of 53BP1 and RAP80 at DSB sites UBC RNF168 RNF8 H2AX BRCA1 L3MBTL1 ABRA PMC7687355__F4 Predicted activation of VEGF signaling after both APAP300 and PHX ADGRF5 MCM6 ANGPTL4 HMMR HOPX MAD2L1 ACKR3 FKBP5 GMNN CYP4A11 AURKB PMC4990112__F2 BRCA1 promotes DNA end resection, but the BRCA1-A complex suppresses excessive DNA end resection PALB2 BRCA2 BRCA1 PMC7687355__F3 Predicted activation of HGF signaling after both APAP300 and PHX EGR1 ADGRF5 HGF HMMR ACKR3 NR0B2 ID1 GMNN TRIP13 PMC7687355__F6 Temporal differences in activation of IL6 signaling after APAP300 and PHX EGFR SNX10 IL6 CSF2RB CEBPB CEBPD CXCL13 TNFRSF1B CDKN1A IGFBP1 STEAP4 SLC39A14 STAT3 PMC3517178__F2 Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression MMP2 TNFSF11 CXCR4 CENPF POLG SMPD1 RORA IL1B PCNA PMC2781439__F7 Speculative model depicting mono-ubiquitination-dependent and independent functions of the FA-BRCA pathway in DNA replication-associated repair processes REV1 GIG8 FANCD2 UBE2T ATR RAD18 PCNA USP1 PMC5118428__F7 K-state regulation in domesticated and undomesticated strains CIPC DES CLPP PMC12247361__F2 miR-1303 regulates cancer progression through targeting multiple genes across distinct cancer types DKK3 HEL-S-79 SFRP1 TLN1 PMC9576687__F3 Premature senescence induced by ischemia/reperfusion injury TREM1 CDK4 IL6 CDK6 PMC9576687__F2 Cellular senescence signaling pathways ATM MYC ATR PMC3909012__F7 Cell Surface Area and Membrane Folding in Glioblastoma Cell Lines Differing in PTEN and p53 Status MDM2 PTEN MTOR PMC11898961__F1 Simplified 5-ALA metabolic pathway ABCB6 FECH PMC3875676__F4 High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells ERBB2 EGFR MYC STK33 PMC11931053__F8 Huoshan Dendrobium Zengye Jiedu Formula mitigates radiation-induced oral mucositis and improves oral immune microenvironment by targeting the EGFR/PI3K/AKT pathway: evidence from network pharmacology, molecular docking, and experimental validation EGF EGFR BAX PMC7687355__F8 Predicted activation of EGF and PDGF signaling after APAP300 compared to PHX at 24 hr EGF FOSL1 THBD MYC ATF3 SIAT4C SOX4 ZFP36L2 ZFP36 EGR2 RRM2 CCNB1 TGIF1 CCND1 ETS2 RHOB PMC8403340__F3 Glutamate-mediated, calcium-related signaling in glioma progression MYH9 PIG59 CDH23 CACNA1B PCDHA1 PCDHA3 DLGAP4 ASPH TGFBR1 PCDHJ MYL2 HOMER1 MTOR GRIK3 CACNA2D1 RYR2 DLG4 CACNA1C FKBP1A CACNA1S GRIN1 MYL12A FKBP1B DLGAP1 ACVR1 GRIA3 MYL10 OTOF CACNG1 TRDN GRIK2 LRFN2 CALM1 CACNA1G PPP3R1 LRFN1 GRM3 GRIK1 GRIN2B RYR3 MYLK CACNB1 PMC6807343__F8 Proposed model IL6 TNF IRS1 IL1B PMC6073120__F4 Endocytic trafficking of PAR1 RAB11A ARRDC3 RAB11B SNX1 PMC6393786__F2 Optogenetic switches RAN PMC4932542__F1 Models that have been proposed to explain the inhibition of tumor cell proliferation by metformin HEL-S-26 IGF1 PMC5341926__F3 Proteomic analysis uncovers common effects of IFNG and IL-27 on the HLA class I antigen presentation machinery in human cancer cells OAS3 APC POMP DHFR MTRR TYMS AADAT ATR JUN HEL-S-20 SP100 PMC9367541__F2 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma ITK LCK GRB2 PMC9367541__F1 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma PLCG1 VAV1 ARHA MTOR ITK CARD11 FYN BCL10 LCK ZAP70 GRB2 SOS1 CDC42 PMC11799259__F2 Interaction between genes/pathways in prostate cancer (A) Rb deletion promotes the expression of genes downstream of the AR pathway through transcriptional activation of E2F and facilitating promoter recruitment of the AR MYC PTEN PMC4542378__F10 Activated signaling pathways that regulate KSHV lytic replication during primary infection PTK2B CREB1 SRC EPHA2 PMC4046911__F2 PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis GADD45B NUPR1 NFIL3 ADRB2 ID3 ACAT2 PMC3466406__F7 Biological insights obtained by combining logical modeling and experimental data EGF HGF GSK3B GRB2 CDK4 TNF CDK6 PMC4516713__F6 Brain signaling network reprogramming in response to mild mitochondrial uncoupling TSC2 TSC1 IGF1R IGF1 ATF4 ARC BDNF SGK1 RHEB PMC9267148__F6 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis CLTA PHLPP2 CSNK2A1 CEP57 TGFBR1 LGALSL TEKT4 ZNF564 TRAPPC2L FP972 COL1A1 RFX4 SNX14 CEBPD RSPO1 ECT2 ACACB ZNF710 ABCB10 AXL SRCAP RORC RELN PLEKHG7 AEBP2 ZNF117 GAB2 TCF4 FOXH1 PMC9313271__F1 Current Concepts of Vitiligo Immunopathogenesis CXCR3 CXCL10 CXCL9 PMC10937991__F8 Graphical abstract IFNGR2 IFNG PMC9267148__F7 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis SKIL CSNK2A1 ZFYVE9 SMAD2 TGFBR1 ERBB3 SMAD4 NRG1 CACNA1A CIAPIN1 ERBB2 ADRA1A PARD6A SKI SHC1 PARD3 FOXH1 PMC8514585__F2 PRMT5 in DNA damage response in prostate cancer NHEJ1 WEE1 RUVBL1 BRCA2 RAD51D RAD51 RAD51AP1 BRCA1 PMC3877845__F1 mTOR signalling pathway TSC2 RICTOR GRB2 YY1 HIF1A MTOR RHEB MLST8 PMC2808051__F20 Reversible phosphorylation regulation of the cell cycle WEE1 ATM E2F2 PMC9008451__F2 Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases NLRP3 BAD TLR4 AHR CXCL10 CCL2 STAT3 PMC6396373__F9 Herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐KB signaling and STING's dual role during MCMV infection TBK1 CGAS IRF3 PMC8615124__F3 Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression HEL-S-26 HEL-S-32 PMC8144889__F3 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension KLHL3 WNK1 OSR1 PMC8144889__F2 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension KLHL3 WNK1 PTH OSR1 WNK4 SGK1 PMC3466406__F2 The integrated large-scale logical model EGF HGF ROCK1 EBP EGFR MYC PTEN MTOR CCND3 CEBPB CDK6 CCND2 CCNE1 NPAT FBXW4 WEE1 ATM MDM2 SRC CCND1 CDK4 SP1 JUN FOS ARHA CEBPA DMP1 HDAC1 FBXW8 RHEB MCM2 CDC6 CDK2 LYN GRB2 ATR MEF2C PCNA SKP2 STAT3 PMC5239799__F1 Integration of non-genomic signaling and canonical signaling of androgen receptor (AR) BAD SRC PMC3801191__F1 Estrogen Regulation of Dkk1 and Wnt/Beta-Catenin Signaling in Neurodegenerative Disease APC GSK3B RPS6 PMC6284793__F8 Known and novel BP associations in the TGFB signalling pathway RUNX3 RUNX2 IRF7 NODAL PITX2 RRAS MAP2K2 SMURF1 HDAC1 TLX2 ACVR2A NKX2-5 GRB2 GSC SKI TGFB1 INHBA FOXH1 PMC5920792__F2 Feedback Regulation of RTK Signaling in Development CS GRB2 PTEN MTOR PMC7203229__F3 Genomic competition for noise reduction shaped evolutionary landscape of mir-4673 TCF3 TFAP2B NPS CTCF TFAP2C TFAP2A TCF4 PMC6543531__F8 Regulated Necrosis and Failed Repair in Cisplatin-Induced Chronic Kidney Disease TP53INP1 NTN1 CDKN1A FOS PMAIP1 PROC LCN2 NR1C2 NRG1 KCNB1 EPHB2 PMC4888836__F1 Model for the noncanonical HDR pathways at two-ended DSBs POLE RTEL1 RAD52 RAD51 ERCC1 MRE11A PMC6657303__F4 Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury NLRP3 KEAP1 ATF4 EIF2A BCL2 BAX PMC6557692__F1 Pro-Inflammatory Cytokine Activation of NFKB in Synovial Fibroblasts RELA TNF FADD PMC10377498__F5 Mitophagy: A Bridge Linking HMGB1 and Parkinson’s Disease Using Adult Zebrafish as a Model Organism HMGB1 TLR4 PARK2 FIS1 PMC3798933__F2 Insulin signaling pathways are inhibited by damage-associated molecular pattern (DAMP)-mediated, Toll-like receptor (TLR)-mediated pathways PI3 TLR4 SOCS3 TRAF3 TRAF6 IRF3 MYD88 TLR1 IRS1 PMC6299398__F5 Affected pathways in group 4 medulloblastoma PCDH9 SUFU GLI3 GSK3B SHH SMO PTCHD4 PMC9496697__F1 GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target TSC2 TSC1 PTEN POR REL PMC8365026__F1 Endoplasmic Reticulum Stress in Cerebral Ischemia QRICH1 ATF4 EIF2A XBP1 PMC6299398__F3 Consequences of driver gene mutations in canonical Wnt signaling GSK3B PIK3CA IRS1 FBXW7 PMC6299398__F2 Affected pathways in SHH-activated medulloblastoma DYNC1H1 SUFU PTCH1 GLI3 SKP1 SMO RBX1 PMC3469602__F4 Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells CAD TNF DIABLO HTRA2 PMC11055311__F1 Main signaling pathways involved in TPL in cancer CDK2 PUM1 MMP9 RELA LRP6 FZD1 SOX17 WIF1 SFRP5 STAT3 PMC4994294__F4 Unigenes involved in the plant hormone signal transduction pathway in SAM of Oriental hybrid lily BAK1 BIN2 EBF2 PMC4124034__F3 Translational Control by Heme-Regulated eIF2A Kinase during Erythropoiesis RET ATF4 EIF2A PMC9503257__F6 Intestinal microbiome-mediated resistance against vibriosis for Cynoglossus semilaevis TBK1 CYP27A1 TANK IRF7 ELOVL5 TRAF3 IRF3 RAC1 TLR1 TLR3 ACOX1 PMC5286530__F1 FGFR signaling pathway STAT1 FGF21 FGF3 TES FGF10 GRB2 FGF22 TK1 FGF7 STAT3 PMC7701218__F9 Proposed CCN3-mediated signaling pathways in placental diseases PE and AIP CDK2 NOTCH1 CDK4 PMC11928779__F8 A‐KG and tRNA deoxygenation in the cytosol and mitochondria FTSJ1 ALKBH1 NSUN2 NSUN3 PMC4036111__F3 Schematic of the FGFR signaling pathway FGFR1 FRS2 FGF2 PMC3616322__F2 Signalling regulation of mammalian autophagy TSC2 TSC1 GRB2 PTEN IRS1 RHEB PMC10530385__F1 Tet1 regulates pathways responding to PM2.5-induced oxidative stress KEAP1 AREG EGFR DNAJB9 HIF1A HMOX1 XBP1 NQO1 AHR IL33 CYP1A1 TGFA TRAF2 HEL-S-72p IL1B PMC8365026__F3 Endoplasmic Reticulum Stress in Cerebral Ischemia EIF2A TRAF2 PMC7377944__F2 Human telomerase in homeostasis and disease TGS1 DCP2 ZCCHC7 PABPN1 XRN1 TERT PMC8645129__F8 Development and characterization of efficient xylose utilization strains of Zymomonas mobilis MAF RP1 REST PMC7643412__F4 Crosstalk between ferroptosis and apoptosis, necroptosis, autophagy-dependent cell death and pyroptosis RIPK1 GPX4 SDC1 APAF1 SLC7A11 RIPK3 CHAC1 MLKL BAX PMC7643412__F3 Published molecular mechanisms of ferroptosis in breast cancer RIPK1 GPX4 SLC7A11 ATF4 EIF2A HEL-S-64p RIPK3 SRC CHAC1 MTDH MLKL STAT3 PMC11928134__F7 HPS1 and ITK function in melanocyte and T-Cell ITK HPS1 IL2 IL6 TNF PMC7643412__F1 Ferroptosis pathways HEL-S-102 GPX4 LPCAT3 FACL4 KEAP1 DPP4 HEL-S-64p IPP HMGCR BAP1 PMC7730978__F1 Gain of function (GOF) effect of mutant p53 and regulation of autophagy by p53 in nucleus TSC2 PML PIN1 MDM2 PTEN MTOR BAX PMC6752729__F1 Summary of molecular basis on which epigallocatechin-3-gallate (EGCG) prevents chronic kidney disease (CKD) and renal fibrosis based on preclinical evidence NLRP3 MPO CDH2 NQO1 PMC11928779__F5 MTOR signaling network CASTOR1 MAF1 EIF4E DEPTOR RHEB MLST8 PMC5676564__F1 Representative signalling pathway of human TLRs in the cell membrane (TLR1/2, TLR2/6, TLR4, TLR5, and TLR10) and endosome (TLR3, TLR4, TLR7, and TLR9) TBK1 TLR9 IRF7 IRAK2 IRAK4 IRF3 MYD88 TLR10 TLR3 TLR7 TLR4 TAB3 MAL PMC6433747__F1 Androgenic-inducible miRNAs involved in the process of BC progression CD44 SOX4 PMC11927577__F3 KEGG signaling pathway analysis of up-DEGs and down-DEGs in AD CTSL GM2A CTSS PIDD1 NCKAP1 MAP2K2 CTSH FLNB CYTH1 PMC8774449__F1 Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases CYP2R1 DHCR7 CYP3A4 CYP24A1 PMC7738566__F3 Enhancer effects in establishing cancer signaling environments RIT1 MXD1 NCOR1 KEAP1 ALK SMAD2 PCDHJ MYC GSK3B SMAD4 RB1 CDKN2A FBXW7 FGFR2 CDK6 TAOK1 CCNE1 TAOK2 NF1 FGFR1 MNT MAPK1 NTRK2 PSEN2 YAP1 ERBB3 APC MLX SFRP5 DKK4 RHEB RICTOR MAX CDKN1A STK4 AXIN1 STK11 MXI1 MGA CRB1 MAML3 DKFZp781B1423 CDKN2C TGFBR1 JAG2 TGFBR2 PPP2R1A INPP4B CCND3 KDM5A CCND2 CHEK2 ARRDC1 ERBB4 NF2 SFRP1 AXIN2 TCF7L1 ARAF KIT WWC1 PDGFRA TAOK3 RAC1 CBL CREBBP EP300 MYCL ERBB2 CRB2 CSNK1D FGFR4 DKK1 MXD4 ACVR2A TLE4 MDM2 ROS1 ZNRF3 SFRP4 CDKN1B DCHS1 FAT1 RET CDKN2B CDK2 ACVR1B TLE2 MLXIP TLE3 IGF1R DNER BRAF EGFR PTEN LATS1 DKK2 MOB1A MTOR RPTOR TEAD2 ATM PTPN11 CCND1 CDK4 SPEN NCOR2 KAT2B RNF43 DKK3 NTRK1 FGFR3 NTRK3 MAP2K2 FAT2 MXD3 WIF1 FAT3 FAT4 MAP2K1 hCG_2014051 RAF1 FLT3 SOS1 PMC8152475__F9 Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis TBK1 IRF3 HK2 PMC9339490__F2 Glioma-neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review) MMP3 MMP9 LYN SRC ADAM10 PMC5798144__F6 Egulation of actin cytoskeleton pathway and the differentially expressed genes on the bare and the TiN-coated NiTi alloys F2 APC INS ABI2 DOCK1 RHO HEL114 GAL PXN CDC42 PMC5798144__F4 TGFB signaling pathway and the differentially expressed genes in both the bare and the TiN-coated NiTi alloy groups BAMBI E2F4 NODAL PITX2 SMAD2 TGFBR1 SMAD4 SKP1 ARHA RBX1 LTBP1 IFNG FST FRK SP1 PMC9610432__F4 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model TANK PMC9610432__F3 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model CD14 TANK IRF9 MAP3K7 TYK2 TRIM25 IFNG PMC523881__F1 The monolignol biosynthetic pathway CAD ACD PMC10454457__F3 Constitutively expressed genes of class I and II major histocompatibility complex processes of endogenous and exogenous antigen processing pathways found in chicken thrombocytes CANX TAP2 HEL-S-99n B2M CD74 TAPBP PMC10454457__F2 Genes of the TLR signaling pathway observed in chicken thrombocytes CD14 TLR5 TANK TLR9 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR7 TLR4 TIRAP PMC11871217__F7 Deduced signaling pathways regulated by LvMmd2 BAD PAQR3 LATS1 RAF1 MMD2 PMC11705844__F7 The mechanism by which BMAL1 deficiency impairs cognitive function BACE1 AREG EGFR APP PMC9118424__F6 Transcriptome and Metabolome Analysis of the Synthesis Pathways of Allelochemicals in Eupatorium adenophorum MVD FDPS PMC9464914__F1 Pinocytotic engulfment of lipoproteins by macrophages CWC22 CD47 TLR4 ACAT1 CCL19 RAC1 CDC42 AKT3 PMC9160457__F9 Attenuation effect of potassium 2‐(1‐hydroxypentyl)‐benzoate in a mouse model of diabetes‐associated cognitive decline: The protein expression in the brain HINT1 LAMTOR2 HAGH MTOR DRP2 CLASP2 PMC6435963__F1 Complement activation cascades and functions HEL-S-62p MASP1 MASP2 C4A PMC3930409__F10 Epidermal growth factor (EGF-EGFR) signalling pathway in hepatocellular carcinoma (HCC) inflammatory microenvironment EGF CXCL5 EGFR CXCL8 IL8RB PMC3901225__F2 Protein complexes and their connection with metabolism PTS POLI PMC6435963__F2 Regulation of complement activation by RCAs or parasite-expressed proteins targeting different complement components at the different steps of complement activation CD59 MASP1 VTN CR1 CP PMC6600670__F8 Mechanism by which EPD attenuates IMQ-induced psoriasis by inhibiting the inflammation responses via TLR7/8–MyD88–NFKB–NLRP3 inflammasome signaling pathways NLRP3 TLR8 TLR7 TRAF6 MYD88 PMC8306788__F1 Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review LATS1 LATS2 PMC4025940__F1 Roles of TGFB in the tumour microenvironment TGFBR1 TGFBR2 SMAD4 MTOR PMC2874439__F3 Schematic representing the significant changes in gene expression in the lung of Keap1Δ2–3/Δ2–3;CctCre+ mice compared with Keap1flox/flox mice AOX1 GCLM EPHX1 GCLC GPX2 ABCC1 HEL-75 HEL-S-128m BACH1 PMC7122036__F1 Transforming growth factor B (TGFB) signaling in aortic aneurysms and dissections (AAD) SMAD2 SMAD4 PMC8229934__F5 Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts STAT1 CXCR3 CXCL10 CXCL9 CXCL11 PMC3328609__F3 Development of the Bile Ducts: Essentials for the Clinical Hepatologist APC GSK3B PMC11505293__F4 Polycystic Ovary Syndrome and Ferroptosis: Following Ariadne’s Thread MUC1 GPX4 FACL4 DPP4 SMAD2 INS TFRC PTEN HIF1A TET1 SIRT3 PHF21A MUC7 ATM PCBP1 HAMP ASCL4 NFE2L2 FTL IL6 TET2 PINK1 NFKB1 ACVR1B SLC11A2 PMC5372284__F4 Phospho-sites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT signaling pathway in a lung adenocarcinoma cell line harboring a L858R mutation in the kinase domain of EGFR, which is reactive to treatment with erlotinib EGF GRB2 EIF4E RPTOR PMC11505293__F2 Updated PCOS network: network depicting the associations (connecting lines) of PCOS-relevant genes/gene products (nodes) GPX4 NCOR1 FACL4 MAPK8 MGLL GPT CAST TROAP CXCL8 CAPN10 DCN MUC7 RAD50 FBN3 IRF-1 GHSR IL1A MAPRE1 HAMP ASCL4 SULT2A1 SETDB1 DLG2 BMP15 TCF7L2 TNF TET2 AVP ACVR1B BCL2 THADA FTSJ1 MUC1 NR3A2 KCNA4 SLC7A11 PRDM2 DPP4 INS TFRC PTEN FSHB BCL2L11 GCG CYP21A2 CNR1 BYSL ZSCAN20 TET1 SIRT3 PHF21A ZNF41 TLR4 ERBB4 AMH ZKSCAN5 SHBG KRR1 HEL-68 KISS1R LDLR ZBTB16 PTPN11 KISS1 PCBP1 DCTN1 ACE2 CYP17A1 IL1B KDM1A NEIL2 HEL-S-89n GNRHR TOX3 NFE2L2 FTL AMHR2 CGA TRIM4 ITGB1 RPS9 PS1TP5BP1 GATA4 CCK PINK1 EP300 NFKB1 TRIM28 SLC11A2 HHEX PMC7865768__F4 Domain structure of SPAK and the phosphorylation target sites on NKCC1 and KCC3 WNK3 OSR1 PMC7462086__F2 SOS1 Gain of Function Variants in Dilated Cardiomyopathy CS MAP2K1 HGF BRAF GRB2 RAF1 SOS1 PMC1456930__F5 The molecular pathways controlling AB generation during aging IGF1R IGF1 PTEN PMC3163738__F3 IFNA (type-I IFN) and IFN-λ (type-III IFN) signal through distinct receptor complexes, but activate the same intracellular signaling pathway STAT1 STAT2 IRF7 IFNK TYK2 JAK1 IFNAR1 MX1 PMC10222048__F3 KEGG pathway analysis of glycolysis and gluconeogenesis CPM G6PC2 PGM2 ACSS1 ALDH3B1 PDHA1 PFKFB1 ENO1 PCK2 HEL-S-281 PMC8446806__F1 Complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain HEL-S-62p C5AR1 C9 C4B_2 MASP1 VTN C7 C5AR2 C6 CR2 C1S CR1 PMC3956809__F4 Tissue-specific expression within individual functions—a case of insulin signaling pathway PRKCI FBP2 PRKAA2 CTCF MTOR HRAS PTPRF FLOT2 ARHG PPP1R3E HEL-S-42 FAP PRKAB2 FASN PMC6786387__F11 Proposed model illustrating the mechanism that underlies NTZ in the amelioration of AD pathology GSK3B MTOR NQO1 PMC12210724__F1 Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population PPM2C GCK PDP2 HEL-S-32 MDH2 GOT2 PC HEL-S-278 SLC2A2 SLC2A3 PDHA1 HEL-S-304 SLC2A9 RPIA OGDH SUCLG2 PDHX PGAM1 SDHD RPE SLC5A2 HEL-S-133P HK2 PGAM2 SDHA SDHB HEL-S-281 ALDOB PDHA2 ENO3 FBP2 SDHC ENO1 DLD HEL-S-68p PDK3 SLC5A9 ENO2 SUCLG1 SLC2A6 HEL107 SLC5A1 CS PCK1 PDK2 SLC2A7 FH SLC2A8 ACO2 SLC2A14 SLC2A11 SLC2A10 SLC45A1 SLC5A4 PFKP DLAT HK3 FBP1 PFKL PDK4 IDH3B HEL-S-87p SLC2A4 SUCLA2 PMC6993488__F3 Inhibiting T cell activity causes anti-PD-1/PD-L1 immunotherapy resistance PTEN TNF PMC5235905__F9 LPS/TLR4 engagement promotes AMPK dephosphorylation and decreased kinase activity in peritoneal macrophages TLR4 MYD88 IL1B PMC7096153__F2 Ingenuity Pathway Analysis PRKCE BRAF GUCY1A2 PLA2G2C RYR2 MEF2D GRM2 PAWR SLC1A2 MAPK1 PAFAH1B1 ADCY1 MAPK10 GRIA3 PLCB1 YWHAQ PRKCB MAP3K2 GRM3 ATP2A2 GNAO1 SLC1A3 PTPA MEF2C CAMK2A GLS AKT3 PMC5338169__F2 The endothelial cell and monocyte in early stages of atherosclerosis: potential mechanisms of milk derived bioactive peptides CCR2 TLR4 CD36 PMC9033766__F6 Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways RUNX2 TNF COL1A1 PMC5524345__F9 Dkk3 gene encodes a vital intracellular regulator of cell proliferation APC LRP5 LRP6 PMC8632642__F8 Co-Exposure of Cardiomyocytes to IFNG and TNFA Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy STAT1 NOS2 SIRT1 PMC8594130__F6 Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm TBK1 IRF3 PMC8234993__F4 Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq. BAD BCR APIP MDM2 CYC1 ENG PTEN RBL2 RHEB CD19 PMC8204019__F4 Radiation Resistance: A Matter of Transcription Factors GPX4 KEAP1 GCLC EGFR NOTCH1 NQO1 HES1 PMC8204019__F3 Radiation Resistance: A Matter of Transcription Factors ATM CCNB1 CCND1 TNF PMC9564311__F5 Potential Fatty Acid Metabolism-Related Gene Signature for Prognosis in Clear Cell Renal Cell Carcinoma ENO3 HPGD ACADL CPOX ALDH3A2 ENO2 CPT2 PMC11853788__F4 Proposed regulatory network involving relevant metabolic pathways in Longissimus dorsi muscle (LDM) after composite plant extracts (CPE) addition PIK3R1 PC CTRL PLA2G2D HEL-S-130P PLA2G4E BAX PMC2981398__F1 Role of the N-end rule pathway in RGS protein degradation RGS8 RGS4 RGS18 RGS2 RGS17 RGS13 RGS5 ATE1 RGS1 RGS6 NTAN1 RGS10 RGS11 PMC7256023__F1 TGFBeta-induced epithelial-to-mesenchymal transition TWIST2 SNAI1 TWIST1 SMAD2 ZEB2 SMURF2 TGFBR1 SMAD4 RHO CDH2 PMC4105632__F1 Nigrostriatal, mesocortical, and mesolimbic pathways TH SST PMC4405749__F6 Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis SIRT1 FOXO1 BAX PMC6129280__F5 piMGM: incorporating multi-source priors in mixed graphical models for learning disease networks PIK3CD PIK3R1 PI3 MAPK12 MAPK13 PPP3CA NFATC1 PIK3CA MAPK11 AKT3 PMC8284093__F7 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney AFP PATJ AMOT APC SMAD4 AXIN2 RASSF6 SMAD1 CTGF PMC9201920__F3 Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer’s Disease MYD88 IL1B PMC7256023__F5 Lipid and choline metabolism in TGFBeta-induced EMT MMP7 SNAI1 CHKA TBR1 ACLY SMS FASN PMC7256023__F3 TCA cycle is active in TGFBeta-induced EMT SDHC FH SDHD SDHA SDHB PMC8069677__F4 Effect and regulation of the NLRP3 inflammasome during fibrosis NLRP3 TLR4 SMAD2 SMAD4 NOX4 TGFBR3 IL1B PMC6314405__F1 Immunological pathways targeted by the main novel therapies for IBD TH ELL MADCAM1 PMC11907837__F2 Wnt/Beta-catenin-related ncRNAs that regulate tumour cell proliferation, metastasis and invasion VAPA APC PLAGL2 EZH2 FOXR2 BRD4 PMC11907837__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC11052502__F4 Results of PPI, KEGG, Reactome, and GO analysis of 19 common proteins that were targets of 1-MNA and RA-associated gene targets PDE4D F10 MMP9 GSK3B MAPK14 PARP1 EIF4E PDPK1 INSR GSTM2 MMP3 CDK2 LCK PMC4794722__F2 Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia ETFB OXCT1 NR0B2 CPT2 PSAP ESRRA KCNE2 NR1C1 APOB LIPA PPARGC1A ACADS ACADVL PLIN5 PEX26 CYP4A11 ETFA ACADM PMC5223024__F1 TLR and the related TNFR and IL-1R signaling pathways CD14 TRADD RELA TRAF3 TRAF6 IRF3 IL6 MYD88 TNF TRAF2 IL1B TIRAP PMC7560924__F5 Resistance and response to insulin by mTORC1 TSC2 TSC1 GRB2 RHEB PMC3787928__F2 Action of Smac mimetics.Notes: IAPs are important regulators of NFKB-activating signaling pathways TRADD RELA SHARPIN RELB IL6 MAP3K7IP1 TRAF2 SMS FADD PMC3418637__F1 Context-dependent effect of PI3K signaling on Treg development, differentiation and maintenance FOXP3 PMC8670233__F2 Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases EBP PMC8527296__F1 Putative type I interferonopathy genotypes CGAS ENPP1 ATAD3A BLM COPA USP18 PNPT1 STAT1 ISG15 OAS1 C1QA POLA1 DNASE2 ATM PSMB9 PSMB8 SAMD9L STAT2 POMP RNASEH2C RNASEH2B RNASEH2A LSM11 IFNAR2 IFNAR1 C1QB PSMD12 RNASET2 NGLY1 TREX1 JAK1 C1QC PSMB10 SOCS1 PMC2394659__F3 Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration CD99 ARHH CD44 ARHA NCF4 RAC1 CRK PXN JAM2 THY1 PMC9139716__F3 Brain Organization and Human Diseases NOG FGFR1 NODAL PTCH1 SHH SMAD4 SIX3 SMO SMAD1 DKFZp781O1323 PMC317355__F3 Wnt-signaling pathway APC GSK3B TEF LRP5 LRP6 PMC10520073__F7 Graphical representation of the regulation mechanism underlying ABC variant rs4810856 and CRC risk STAU1 PTEN PREX1 TF PMC9030470__F3 Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis PRC1 RYBP RBBP4 RBBP7 ME3 PMC6959099__F2 Metabolic changes associated with innate immune responses in lung disease IL33 TSLP PMC2409816__F1 Schematic representation of the major pathways of ganglioside biosynthesis GAL ST8SIA1 SAT2 B3GALT4 PMC5372671__F1 Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway NF1 TSC2 UBE3A TSC1 PTEN EIF4E DEPTOR CYFIP1 RHEB PMC6959099__F1 Catabolic and anabolic metabolism in the cell ARG2 ASL HEL-S-162eP PMC4387288__F2 BCL6 targets Tfh genes mainly involved in T cell signaling, differentiation, and migration pathways to drive the GC Tfh phenotype CCR6 TGFBR1 TGFBR2 IL1R1 MTOR IL23R FOXP3 IFNG BCL6 STAT1 TBX21 STAT4 CCR7 KLF2 IL2RA RORA IFNGR1 GATA3 IL2RB STAT3 PMC3101870__F1 Three levels of regulation of the IGF-IR pathwayand its components BAD IGF1R GRB2 PTEN MTOR IGF2R GHRH PMC4335252__F10 Molecular mechanism of attenuation of the PI3K/Akt signaling pathway by gingipains BAD MTOR PMC3145576__F5 Pathway analysis of proteins detected at elevated concentrations during time course analysis in lung following intratracheal instillation of 20 μg carbon nanoparticles (CNP) F7 VWF IL4 TNF CCL22 IL1B PMC3266776__F2 Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma APAF1 E2F2 CDC2 SKP2 PMC6014593__F2 Summary schematic of eye morphogenesis pathways ARHA RAC1 RPE CDC42 TRIO PMC5138592__F5 Identification of critical paralog groups with indispensable roles in the regulation of signaling flow NOTCH4 DTX1 SMAD2 JAG2 GSK3B DTX4 LFNG MFNG DLL3 ADAM17 LEF1 DLL4 NOTCH1 UNK ADAM10 MDK ITCH PMC7789255__F2 Possible paracrine mechanisms controlling differentiation of spermatogonia in adult testis LRAT CYP26B1 CRABP2 NANOS2 STRA8 RBP4 HEL-S-53e FSHR RDH10 SOHLH2 RXRA PMC7789255__F1 Possible paracrine mechanisms controlling self-renewal of spermatogonia in juvenile testis LIN28B CRABP2 SOHLH2 CYP26A1 LRAT RET CYP26B1 CYP26C1 ZBTB16 CRABP1 GDNF RDH10 SOHLH1 REC8 RDH11 PMC5883534__F4 BRAF kinase inhibitor resistance and alternative activation of MAPK targets and pigmentation HGF PDGFRA YAP1 ADCY1 SMAD2 CREB3 EFNA2 SMAD9 PLCB4 FGFR1 EDNRB PDGFC EP300 DCT DUSP2 EPHA2 OCA2 TF PMC4439419__F1 Cell cycle arrest in senescent cells CDK2 APC CDK4 CDK6 PMC2633067__F2A Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells HEL-S-11 F2 APC INS DOCK10 ABI2 RHO HEL114 PXN PMC3982775__F1 Structure of the systems model of type C4 photosynthesis GCA GIP HPR MAL PMC4051248__F9 LPS up-regulates the PhT2 signaling pathway CD14 TLR4 MYD88 TIRAP PMC7509264__F1 Resolution of inflammation in immune and nonimmune cells by interleukin-19 IL20RA IL20RB STAT3 PMC3191051__F9 Model for TGFB1-mediated signaling to the miR143/145 regulatory region SMAD2 MYOCD SMAD4 TGFB1 PMC3257565__F2 HSC cell cycle entry is regulated by a complex network of cell-intrinsic and cell-extrinsic factors TSC2 TSC1 CDK2 TPO CDK4 BMI1 PTEN JUNB MTOR CDK6 HES1 PMC8291015__F1 Impact of the COVID-19 pandemic on inflammatory bowel disease patients: A review of the current evidence ACE2 ADAM17 TMPRSS2 PMC3405739__F2 The processes included in the insulin model PI3 PTEN PMC8114202__F5 Thyrotrophin and thyroxine support immune homeostasis in humans TLR8 TLR7 TLR9 IRF7 IRAK1 TRAF3 TRAF6 CD40 PMC3007169__F1 Arsenic: a potentially useful poison for Hedgehog-driven cancers SMO PMC9379413__F3 Phase separation in Cancer: From the Impacts and Mechanisms to Treatment potentials APC GRB2 LATS1 MED1 DACT1 BRD4 PMC4101819__F1 Key signaling pathways involved in genetic methylation of lymphoid malignancies APC GSK3B MDM2 PMC8453085__F5 Th17 Cells in Periodontitis and Its Regulation by A20 NLRP3 RIPK1 GSDMD PMC5759028__F8 KRAS/TGFB/p15Ink4b pathway controls the cell fate EGR1 RB1 TGFB1 PMC3736320__F1 Déjà vu: EGF receptors drive resistance to BRAF inhibitors EGF IGF1R HGF NRG1 PTEN PMC6520855__F2 Targeting the Hedgehog pathway KIF7 SMO DYRK1B BRD4 PMC6520855__F1 Hedgehog pathway in absence (a) and in presence (b) of HH ligand KIF7 PLK1 SUFU GLI3 GSK3B SMO DYRK2 ADRBK1 DYRK1A PMC6751615__F5 Possible pathways for the synthesis of bioactive stress mediators from the arachidonic acid (AA) cascade in the immune tissues of chickens SET COX1 TES PMC9395317__F4 Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy IL10 EGF HGF SMAD2 MMP9 APC PDK2 GSK3B SMAD4 ARHA CCL2 MAP3K7IP1 IL18 CXCR4 GRB2 SRC CXCL12 CDH2 STAT3 PMC7900639__F2 Drug induced ER stress response regulation in trypanosomes: (a) Elevated expression of Sirtuins in ER stress might activate autophagy by deacetylating ATG proteins, and sirtuins regulate subsequent switch to apoptosis at a higher stress level UFM1 EIF2A UBA5 DKFZp686F0183 PMC6992650__F5 Kaposi sarcoma-associated herpesvirus infection pathway from KEGG NPAT STAT2 FRK MIA PMC8268416__F1 Plant responses to geminivirus infection: guardians of the plant immunity EML1 GRIK1 DKFZp686F0183 PMC1937548__F4 Comparison of nonsynonymous substitution rates among members of RB and p53 signaling pathways MDM2 CDK4 CDK6 PMC5835320__F7 Canonical pathway analysis for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis GCA PLPP2 RBBP4 EGFR CDS2 MYC ANXA3 DNAJC8 ARHGAP19 RHO SF3A1 IKZF1 BACH2 KNTC2 PKP3 NXN CCND1 ABCC2 IRF2 BTN2A1 PRR3 ACTR2 CMTM4 ME1 MRPL37 SDC1 GULP1 SPDEF TCF19 TCF7L2 ASAP2 ID1 CNTRL AURKB NFKB1 IGFBP1 RYR3 COASY ATAT1 CP CPD PMC5835320__F6 Network pharmacology for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis GCA RBBP4 MYC ANXA3 ARHGAP19 MYL3 PRIM2 TFDP2 TACC2 SF3A1 IKZF1 BACH2 KNTC2 PKP3 NXN CCND1 COX11 IRF2 PRR3 ACTR2 CMTM4 MRPL37 PLS1 SPDEF TCF19 TCF7L2 ID1 CNTRL GRB7 AURKB HEL-S-171mP NFKB1 IGFBP1 RYR3 COASY CPD PMC6912660__F1 The main estrogen receptors signaling pathways: in the genomic pathway, classic estrogen receptors (ER A and B) act as transcription factors upon homo- or heterodimers EGF BRAF SOS1 PMC3390969__F2 Impact of a negative regulator on pathogenesis and the development of sepsis, secondary to acute insults CD14 CD163 TRAF6 MYD88 PMC9513370__F3 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis AHR TNF FOXP3 PMC9513370__F2 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis CD80 LAG3 TSLP FOXP3 PMC4887024__F5 Feed Efficiency within a Pedigree Male Broiler Line: I. Highlight on Mitochondria CTH ALB NFE2L2 GPX1 ACTA1 RPL30 PFKM ARF1 HEL-S-104 PAH HEL-S-31 INSR RPL12 RICTOR LDB3 AAG1 PPA2 HEL-S-44 PPIB RYR3 PSMD2 PSMD1 PMC10239456__F3 Interaction graph and dynamic behavior of the PanNETs Boolean model PDX1 MYC MDM2 MEN1 PTEN SKP2 PMC7022928__F1 Retinoic acid signaling pathway LRAT CRABP2 RBP4 PMC2908393__F5 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy LDLR ABCA1 APOE PMC5275772__F4 Beneficial effects of hepatic CAV‐1 on atherosclerosis protection in DKO mice CYP27A1 LDLR TG PMC5854367__F1 Most of Theileria parva proteins involved in glycolysis and tricarboxylic acid cycles were identified in this study PC FH OGDH HEL-S-68p HEL-S-162eP PMC2908393__F4 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy VLDLR LDLR PMC2908393__F3 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy BACE1 LRP1B PMC4845657__F7 Nuclear factor KB1/RelA mediates inflammation in human lung epithelial cells at atmospheric oxygen levels NFKB1 RELA TNF PMC9647533__F7 MicroRNA-16 inhibits the TLR4/NFKB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea TLR4 IL6 IL1B PMC9684507__F6 rs28714259 risk (A) allele dysregulates genes following dexamethasone/doxorubicin combination treatment and contributes to an attenuated hypertrophy signaling IGF1R DIAPH2 PDE10A PLD6 RHO EIF4EBP1 PMC6750724__F5 Proposed biosynthetic pathway of pepticinnamin E HEL-S-62p MT3 PCM1 PMC8225795__F3 Comparison of genetic alterations of signaling pathways in AFPGC and TCGA-GC EGFR MYC PTEN RB1 MTOR CDKN2A FGFR2 CDK6 CCNE1 NF1 PIM1 ERBB4 FGFR1 ATM MDM2 CCND1 CDK4 ERBB3 VEGFA BRCA1 TSC2 EP300 MAP2K1 CDKN2B BRCA2 ERBB2 MCL1 ATR PMC10034899__F1 Sirtuins in attenuating plaque vulnerability in atherosclerosis NLRP3 HMGB1 IL6 PMC3730813__F2 Pattern Recognition Receptors in Intestinal Inflammation TLR5 TLR4 NOD1 TRAF6 IRF3 MYD88 NOD2 TLR3 PMC10486880__F4 Anti-cancer mechanisms of leeks and their active compounds MTOR DKFZp686F0183 BAX PMC3730813__F1 Pattern Recognition Receptors in Intestinal Inflammation NLRP3 NLRC4 IL1B PMC4996775__F9 Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson’s disease HP RPE TF PMC9309601__F2 Cytokine storm: behind the scenes of the collateral circulation after acute myocardial infarction PI3 CCR2 ACVRL1 SMAD2 TGFBR1 CCL2 SMAD1 IL1B DKFZp781O1323 PMC6316710__F1 NCOA4-mediated ferritinophagy pathway is regulated by intracellular iron HERC2 FTH1 COIL PMC9289867__F4 Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways PMC5859839__F11 Pathway of compound-known target-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) EGF CHUK PPP3CA NR3A2 HSP90AB1 ACACA MYC BCL2L1 PTEN CCL2 MTOR INSR IFNG MMP3 PRKCA KDR MMP2 SI opn IL2 CD40LG CDC2 CHRM2 NOS2 IL4 IRF-1 JUN IL1B HK2 SELE BAX IL10 FOS PTGS2 MAPK10 CXCL2 IL6 TNF RXRA IKBKB NFKBIA PRKCB RELA BCL2 ADRA1A RAF1 SIRT1 PMC8141035__F5 The actions of Pirh2 and KLHDC10 in mammalian RQC NEMF ANKZF1 PTRH1 KLHDC10 PMC8786145__F2 Renal Sensing of Bacterial Metabolites in the Gut-kidney Axis OR51E2 MTOR PMC8650627__F8 Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation CS EGFR PTGER3 DRD2 DRD4 CNR1 STAT1 MMP3 GRM2 IL18 PC PTPN11 APP SRC IL2 NOS2 JUN OPRM1 PTGS2 VEGFA IL6 TNF SSTR2 DRD3 CNR2 GABBR1 ERBB2 GRM3 PPARG PMC3893527__F4 Signal pathways involved in renal IRI TLR4 MYD88 IL1B BAX PMC4314580__F2 Signaling pathways in T/NK-cell proliferation TRADD TRAF5 TRAF1 LYN TRAF3 SYK TRAF2 PMC3004747__F1 Fucose is on the TRAIL of colon cancer POFUT1 EGF FUT8 POFUT2 PMC4314580__F4 Treatment strategies for inactivating EBV infection or EBV-associated oncogenic pathways BCR LYN MDM2 SYK PMC7767644__F1 Autophagy is mediated by multiple signaling pathways that creating an interaction network system TSC2 ULK1 TSC1 FOXO3A MTOR RHEB PMC6588588__F2 T cells are differentiated into multiple T cell subtypes including Th1, Th2, T-fh, Th17 and T-reg cells STAT1 TBX21 STAT4 GATA3 BCL6 FOXP3 PMC1133795__F3 Functions of NFKB1 and NFKB2 in immune cell biology LTA RELA LTB RELB PMC11431580__F2 Schematic presentation of the interaction between estrogen receptor (ER) and the PI3K/AKT/mTOR pathway PLK3 CDK2 CDK4 CDC2 MTOR CDK6 PMC6140770__F9 Regulation of AMPK signaling in DM1 muscle STAU1 MBNL1 SIRT1 DMPK PMC11431580__F4 PI3K (phosphatidylinositide 3-kinases)/PTEN (phosphatase and tensin homolog gene)/Akt pathway PTEN MTOR PMC8998487__F3 SUMO E3 Ligases in Signaling Pathway of Cancer Cells PML TWIST2 SLX4 SMURF2 HEL113 PTEN RAC1 PMC7396583__F8 Model illustrating potential regulation mechanism of membrane lipid metabolism in peanut cold tolerance DGAT1 PC GPAT2 LPA ACOX1 PMC5938282__F5 Unique genetic cassettes in a Thermoanaerobacterium contribute to simultaneous conversion of cellulose and monosugars into butanol PTS XYLT1 HBD ENO1 ENO2 HEL-S-162eP PMC4208312__F1 B-cell receptor (BCR) and its downstream pathways PLCG2 PTEN MTOR CD79B CD79A BTK BCL10 BCR BASH LYN SYK AXL CD19 PMC120784__F8 Outline of the cell integrity pathway ROM1 PMC6235217__F2 Pathway analysis within the identified metabolites in the (a) tocilizumab plus methotrexate, (b) tocilizumab, and (c) methotrexate strategy arms COX2 PC COX1 LPA CERS6 PMC7755393__F10 Oxidant quenching cycle drives the proton leak in MS-275-treated adipocytes DKFZp686O2396 ACADL UCP1 ACADS CPT1A GPX1 CPT2 PRDX5 PRDX3 ECHS1 ACADM HEL-S-5 PMC4208312__F4 Multiple event model for B-cell lymphomagenesis BTK CARD11 BCL10 BCR BASH LYN SYK PLCG2 PTEN MTOR AXL CD19 PMC9647636__F10 Crosstalk between TBK1/IKKE and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury TBK1 STAT1 TLR4 IRF3 TYK2 JAK1 PMC11854110__F2 Action of circRNAs participated in the chemotherapy resistance of cancer YBX1 SMAD2 STK11 SMAD4 RAF1 WNT2B IL6R STAT3 PMC7318814__F6 Summary of mechanisms of action underlying MEMP HT in BC cells ELF5 RUNX2 PMC9686736__F4 Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism HEL-S-62p ATM SSB STAT3 BAX PMC8867251__F7 Inhibition of the VEGF signaling pathway attenuates tumor-associated macrophage activity in liver cancer MTOR PMC9386506__F6 Microsatellite DNA-derived oligodeoxynucleotide attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting the HMGB1-TLR4-NFKB signaling pathway HMGB1 TLR4 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TAB3 PMC6425874__F3 Protein networks around RXFP2 (red) RLN2 GNB2 RLN3 RXFP4 GIPR GPBAR1 RXFP3 INSL3 AVPR2 GCG GPR176 GCGR GNB3 ADCY5 MC1R FSHR RXFP2 GNB1 GNB4 PMC10932966__F1 Two Sphks play different roles NLRP3 SPHK1 SPHK2 STAT3 PMC7472175__F1 Schematic model for T-cell receptor signaling GRB2 HEXIM1 LAT PMC10932966__F3 Distribution of S1P is strictly controlled and involved in innate and adaptive immunity APC SPNS2 CD69 PMC6591247__F8 FOXP1-induced CLRN1-AS1 suppressed pituitary prolactinoma by acting as a ceRNA to regulate DKK1/Wnt/Beta-catenin pathway DKK1 PMC7287590__F3 Canonical aryl hydrocarbon receptor (AhR) activation pathway AIP AHR PMC7287590__F4 Proposed models of NLRP3 inflammasome inhibition via AhR pathway NLRP3 AHR IL1B PMC11872079__F8 Schematic model illustrates the role of Sirtuin 5 (SIRT5) in the regulation of follicular recruitment in chickens through its influence on the autophagy-lysosome pathway in granulosa cells (GCs) SIRT5 F2 F5 F3 PMC3754142__F3 Oncogenic and antiapoptotic functions of KSHV ATM SMAD2 MDM2 CDK4 SKP2 BAX PMC5738879__F9 Signaling pathway in the adhesion of stem cells to bone biomaterials PAK1 VTN SRC CHAD PMC9099768__F1 Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin SOCS3 MTOR STAT3 PMC5431132__F2 Endoplasmic reticulum‐associated degradation (ERAD) and unfolded protein responses (UPR) ATF4 EIF2A XBP1 PMC9128097__F1 Rhythm disturbance in osteoarthritis CRY1 NAMPT ADAMTS5 CRY2 SMAD2 SOX9 TNC MMP14 DBP NR1D2 ACAN COL2A1 SMAD1 NR1D1 SIRT1 IL1B PER2 PER1 PMC8524703__F1 Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments (Review) KLLN PDGFRA CDKN2C DKFZp781B1423 EGFR PTEN RB1 MTOR CDKN2A CDK6 NF1 CDKN2B KRIT1 MDM2 CDK4 PMC7549271__F1 Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders UGT8 PMC5261002__F2 Gene network associated with ‘cell death and survival, DNA replication, recombination, and repair' in sPIF-treated EVT NODAL TNFSF14 PAXIP1 BCL2 IL6 PLCD3 CECR2 GRN INHBA IFNG BAX PMC12240642__F1 Ubiquitination‐mediated degradation of EGFR‐EGF complex and inhibition of downstream signalling in EGFR‐mutated cancer EGF EGFR STAT3 PMC3235907__F1 Clopidogrel activation and platelet aggregation pathways F2R CYP3A4 F2 VWF ADCY3 CYP1A2 PMC2575400__F2 MiRNA Signature of Prion Induced Neurodegeneration CASP3 DAZAP2 ETV6 UBE2G1 KPNA3 UBE2E3 XBP1 CP SRP19 PMC4072629__F3 VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome CNTN1 FOSL2 CYP51A1 TAOK1 HPGD VAV3 SLCO1A2 MAGI1 PARVG CAMK2D NMB DNM3 HRH3 SPATA24 STX1B KCNA2 VAMP1 REG3A ASAH2 KCNA1 PLCB4 NTSR1 EDNRB KCNC1 NFIL3 SYNM SKP2 COL4A2 PMC9477374__F6 EA activated EPO mediated Src signaling pathway and VEGF signaling pathway to promote angiogenesis in CIRI rat brain tissue EPOR EPO SRC PMC3660836__F6 O-GlcNAcylation in FGF signaling OGA OGT PMC4249544__F3 Central carbon metabolism, including glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle FOS CIT MAL PMC4866030__F1 NFKB signaling pathway with genes associated with objective PNMS EGF TANK NGF GSK3B RELB PLCG2 MYD88 PELI1 CARD11 RELA CD40 TGFA TIRAP TAB3 PMC7312833__F6 Functional relationship between GFAP+ (glial fibrillary acidic protein) reactive astrocytes and IBA+ (ionized calcium-binding adapter molecule) activated microglia CXCR3 HEL-S-62p HMGB1 TLR4 CXCL10 GFAP LCN2 PMC7312833__F5 Chemokine signaling pathway CXCR3 CCR5 CCR2 ITGB3 CXCL10 GFAP LCN2 CCL2 STAT3 PMC7312833__F2 Canonical and non-canonical inflammasome pathways NLRP3 IL1B GSDMD PMC7312833__F1 Toll-like receptors (TLRs) signaling pathway TBK1 HMGB1 TLR4 TRAF3 TRAF6 IRF3 IL1R1 TNF IL1B TLR3 PMC4586772__F1 Inhibitors have been developed for their ability to block Hh signaling at various signaling nodes in the pathway SUFU PTCH1 SMO PMC7312833__F4 Interleukin (IL)-6/Grp130-JAK-STAT signaling pathway SOCS3 FOXO3A SMAD2 TGFBR1 TGFBR3 STAT3 PMC7312833__F3 Tumor necrosis factor A (TNFA)/TNFR1 signaling pathway RIPK1 TRAF2 IL1B PMC4702912__F6 ‘Wnt Signaling pathway’ from KEGG () (ID hsa04310) ROCK2 BAMBI APC SOST LRP5 CER1 SMAD4 LRP6 SKP1 ARHA RBX1 NLK DAAM1 SIAH1 PMC6966455__F8 Signaling pathway involved in GR cells with ROCK2 inhibition ROCK2 SP1 PMC3612035__F7 Non-Canonical CRL4A/4BCDT2 Interacts with RAD18 to Modulate Post Replication Repair and Cell Survival ATM HLTF ATR CDT1 RAD18 PCNA PMC4127377__F9 MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 MAF DEPTOR SOX9 PMC5576693__F4 Study on molecular mechanism of ANOS1 promoting development of colorectal cancer SFRP4 LEF1 HEL2 SMURF2 ANOS1 SFRP1 ROR2 DKK2 FZD1 DACT1 CTHRC1 PMC7682230__F3 Hypoxia signaling pathway involves EGLN1-mediated hydroxylation and VHL-dependent ubiquitination of HIF-1A/2A subunits leading to its proteosomal degrardation under normoxic conditions IKZF1 VHL SP1 HIF1A EGLN1 PMC6235775__F4 Intracellular calcium regulates muscle atrophy via calpain regulated Ub-proteasome pathway and apoptosis HEL-S-11 BAX PMC3712188__F3 Autophagy and polyglutamine diseases RAP2B INS BCL2 PMC3712188__F2 Inducing autophagy by inhibiting the mTOR pathway.mTOR is a downstream effector of the class I phosphoinositol 3-kinase (PI3K) pathway TSC2 ULK1 TSC1 RHEB MLST8 PMC3966871__F3 High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells SRP54 GLB1 CNTN1 ATF2 HRBL PITPNB PRAF2 UBE2S DHRS1 HEL103 EIF3D SCD GCS1 EIF3B TMEM165 AXL KLF16 P4HA2 PLP2 LYZ BCAM BAIAP2 NRCAM PSAP NUP210 AURKB SEC16A ELF3 FADS2 CDK2 LAMC1 ERC1 IFIT3 IFIT2 ASCC2 ASPH EEF1A2 TOP2A SLMAP CLU VMA21 ISG15 TGOLN2 ECT2 DNAJB12 CCNB1 APP PEG10 CDK4 CHCHD2 JUN NDUFB11 LONP2 GRAMD1A HYOU1 MMADHC AURKA CASKIN2 POLR2D RRP36 CPSF2 PRPF39 CREBBP GOLPH2 RELA KIF20A RBM22 TGFBI PMC8293491__F6 Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease PIK3R1 MAPK9 ARHH HEL-S-1 PRKAR1A GSK3B NRAS CREB1 EIF2AK2 CXCR6 PDPK1 OSMR STAT1 PDHA1 NOTCH2 HEL70 MAP3K1 WASF2 VAV1 CXCL10 IFNAR2 EIF4E LMNA THY1 TIAM1 PAK1 TBX21 PRKCB IGF1 ITGA6 AXIN1 GRB2 CXCL9 BCL2 ITGAV CXCL12 PYCARD ACTG1 NFKBIE GNB4 OLR1 EIF2S1 CX3CR1 TGFBR1 TGFBR2 TFRC EIF4EBP1 CCND2 LCP2 LPIN1 GNG2 RBPJ RUNX1 NFAT5 NFATC1 EEA1 IGF2 NFATC3 FLOT2 GNG12 CXCR3 TNFSF10 STAT4 SYK MCL1 SHC1 PXN DKFZp781O1323 NCF2 CCL3 STAT3 PMC9465167__F1 Human immunodeficiency virus-1 core: The Trojan horse in virus–host interaction TBK1 CGAS CPSF6 IRF3 PMC4730296__F1 Outline of melatonin biosynthesis and function ME1 AANAT PMC8745614__F4A Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells EFNB2 RELB MAP3K14 PTEN CP PMC6095005__F3 Mechanisms involved in the induction of depressive symptoms in inflammatory conditions (gray arrows) and potential therapeutic implications following pharmacological or nutritional interventions (blue arrows) TH KMO PAH PMC6095005__F2 Inflammation-associated BH4 pathway TH DHFR PAH PMC4437198__F1 Genetic Variants in the Fibroblast Growth Factor Pathway as Potential Markers of Ovarian Cancer Risk, Therapeutic Response, and Clinical Outcome FGFR1 FGFR2 FGF7 PMC8204019__F1 Radiation Resistance: A Matter of Transcription Factors MUC1 STAT1 STAT3 PMC8293691__F2 Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target MFN1 NLRP3 CGAS TLR9 MTOR FIS1 OPA1 BAX SIRT3 PMC8226175__F1 Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy UBR5 SENP1 USP28 MYC HUWE1 RNF4 RLIM TRIM32 USP36 USP37 SPOP FBXL16 USP22 ELL PMC7563533__F2 Key databases as primary resources for drug repositioning PTH HEL-S-29 PMC3606591__F1 Novel approaches to inhibitor design for the p110B PI 3-kinase TEC RHO PTEN PMC3676754__F2A The Brassinosteroid Signaling Pathway—New Key Players and Interconnections with Other Signaling Networks Crucial for Plant Development and Stress Tolerance BAK1 BIN2 PMC1065305__F1 Components of the AhR-mediated lacZ reporter assay AHR GAL PMC10818625__F2 Pharmacological interventions against necroptosis in pneumonia RIPK1 TLR4 RIPK3 MLKL PMC10818625__F1 Mechanism by which pathogenic infection causes cell necroptosis TRADD RIPK3 TLR3 ZBP1 STAT1 RIPK1 TLR4 JAK1 TRAF2 IRF-1 FADD MLKL TAB3 PMC6166407__F1 Pro-tumorigenic functions of GPNMB ECD NRP1 EGFR SRC ADAM10 GPNMB PMC11898298__F6 Ironomycin cytotoxic effects alone and in combination with other drugs BTK CARD11 GPX4 BCR BAX PMC6726297__F1 Cholesterol-dependent inflammatory response and cell death in the hepatocyte ABCG8 ABCG5 TG IL1B PMC8705762__F3 Sperm-Guiding Unconventional Prostaglandins in C. elegans: Synthesis and Signaling INS SGK1 PMC4711336__F1 TGFB signaling and regulation BAMBI SMAD2 PMC4160341__F3 Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells PAK1 ARHGEF7 ECT2 ARHA CDC2 PMC4142219__F3 Characterization of glycoproteins in pancreatic cyst fluid using a high performance multiple lectin affinity chromatography platform CCK AMY2B CTRL ARHA RAC1 PNLIP CFTR PMC7346227__F2 Primary cilia control Hedgehog pathway output SUFU PTCH1 GPR161 GLI3 MYC SHH SMO PMC5429551__F2 The dual role of TGFB in tumor progression and its association with RAC1b and RAC1 expression SMAD2 RAC1 PMC9047778__F2 Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease CXCR5 MTOR ICOS BCL6 PMC8222406__F10 CSC-associated AKT/TSPYL5/PTEN loop signaling pathway ALDH1A3 EGFR CD44 HEL-S-53e PTEN TSPYL5 PMC3360606__F1 Integrative Gene Regulatory Network Analysis Reveals Light-Induced Regional Gene Expression Phase Shift Programs in the Mouse Suprachiasmatic Nucleus DUSP14 CRY2 FOS AVP NPAS2 JUN NMBR VIP BRS3 PMC8358691__F1 Physiological impact of in vivo stable isotope tracing on cancer metabolism PC GC GLS PMC8286839__F14 Recruitment of repressors leads to termination of transcriptional responses NLK CRP CSA2 CITED2 PMC2720262__F1 Summary of consequences on signal transduction and brain architecture of conditional Pten or Pdk1 deletion, alone or in combination RS1 TSC2 TSC1 GSK3B GSK3A PTEN EIF4E MTOR RHEB PMC11274695__F4 Protein interactions in plant hormone pathways confirmed using BiFC EHD1 EHD2 ARF5 PTPA ARF1 PMC11274695__F3 Interacting proteins in the classical cell signaling pathway validated using BiFC IL10 BATF3 PLP2 ATG3 FOS APC EMP3 MYC TRAF6 AJUBA MYD88 CDKN2A RAP2A CACYBP FLOT1 HTATIP2 TMEM134 CCND1 PMC6078990__F1 YAP regulates innate antiviral immunity via a transcription-independent mechanism TBK1 TEAD3 CGAS TEAD4 IRF3 LATS1 LATS2 MAVS TEAD2 PMC6025041__F4 Metabolic pathways influenced by transcriptional factor O-GlcNAcylation OGA OGT SP1 PMC11825788__F2 Neuropeptides released from nerve endings and receptors on GCs are illustrated TRPV4 MUC5AC EGFR FOXA3 SPDEF TRPM5 CALCRL VIP TRPV1 TRPM8 FOXA2 PMC6690701__F8 Several H2S-sensitive metabolite changes map to redox active nodes in central carbon metabolism MAL HEL-S-162eP PMC4870087__F7 Dominant-negative GA subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease PLCB4 DLX6 DLX5 PMC6025041__F3 HBP modulates cancer metabolism through the O-GlcNAcylation HEL-S-30 OPA1 FASN HEL-S-162eP PMC8175487__F8 Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation CDK2 GPX1 H3F3B GRB2 NR1C1 PMC8323274__F6 NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway SOCS3 NR1D1 STAT3 PMC6025041__F1 Hexosamine biosynthesis pathway NAGK PGM3 OGA OGT PMC4693901__F2 Protein kinase C (PKC) involvement in cytoplasmic signal transduction pathways in the immune system TBK1 PLCG1 IRF7 APC TRAF6 IRF3 IL6 MYD88 IFNG TLR4 BCL10 BCR TIRAP PMC6248440__F2 Schematic representation of miRNA (left) and piRNA (right) biogenesis DGCR8 DROSHA RAN PMC3180046__F2 NFKB signaling pathways IRAK1 RELB TRAF3 TRAF6 IRAK4 MAP3K7IP1 BCL10 PDLIM2 BCR CYLD RELA CD40 TRAF2 LTBR PMC8943305__F8 Clinical and Apoptotic Factors Defining and Predicting Steroid Resistance in Nephrotic Syndrome in Children HP BCL2 BAX PMC10816282__F7 Proposed scheme for transcriptome stress response to APS FOS EIF2A JUN PMC10745077__F6 Pro-apoptotic Bax-induced release of cytochrome stimulates the caspase signaling pathway in the mitochondria, resulting in enhanced hepatic cell apoptosis CASP3 CASP9 BAX PMC10816282__F6 Transcription response to APS of the JNK/MAPK (A), JAK/STAT (B), Toll and Imd (C) signaling pathway genes in the control and GagrRNAi females and males PMC11529284__F3 Sodium taurocholate co-transporting polypeptide expression HNF4A FGF19 FGFR4 SIRT1 PMC5979829__F8 LIF and the PI3K/Akt signaling pathway LIF TBX3 PMC5750128__F7 Schematic drawing showing the effects of IGF-1 and ALC on prepubertal Kp synthesis and release RS1 TSC2 IGF1R IGF1 MTOR IRS1 RHEB PMC8674954__F8 Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation IL21R PC BCR GC CD40 CR2 CR1 PMC4413635__F1 Cyclin alterations in diverse cancers: outcome and co-amplification network CDKN2B ERBB2 CDK2 CDK4 RB1 MTOR CDKN2A CDK6 PMC8889522__F2 An insight into the mechanisms of COVID-19, SARS-CoV2 infection severity concerning Beta-cell survival and cardiovascular conditions in diabetic patients ACE2 ADAM17 TMPRSS2 PMC11995161__F2 Role and regulatory mechanism of LAPTM4B in tumors LAPTM4B TFEB SLC39A2 EGFR CDK12 DKFZp686F0183 RHEB NEDD4 PMC8235525__F2 Metabolic Choreography of Maize Plants Treated with a Humic Substance-Based Biostimulant under Normal and Starved Conditions HEL-S-62p IMPACT MAL PMC3195649__F2 Targeted therapies for breast cancer PTEN RHEB PMC5893285__F3 Involvement of miR-126 targetome in focal adhesion signaling pathway from KEGG is shown BAD FYN SHE PTEN JUN PMC5893285__F2 miR-126 is involved in neurotrophin signaling pathway pathways including IRS1, PI3K and IKB, which their partial diagram collected from KEGG pathway is demonstrated BAD DAO RAE1 HEL-S-11 FES TRAF6 IRS1 PMC10552782__F2 Regulatory Mechanism of Iguratimod on Signaling Pathway (IFN, interferon; TNF, Tumor necrosis factor; IL, Interleukin; Th, helper T cells; Treg, Regulatory T cells) EGR1 IL6 DLX5 TNF JUN IFNG PMC3948174__F1 Regulation of G protein-mediated signaling by RGS2 in the heart GCA PGC RGS2 PMC6328940__EV1 B‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice COQ4 COQ3 COQ2 COQ10A COQ9 COQ6 COQ5 COQ7 COQ8B PMC7747191__F2 Toll-like receptor signalling in B cells during systemic lupus erythematosus TLR7 BCR CXCR5 LAG3 IFNG PMC11904754__F6 GALNT proteins involved in lung cancer and pathway related GALNT4 GALNT6 GALNT3 GALNT1 PMC11904754__F5 The GALNT14 protein regulates the occurrence and development of lung cancer SMAD2 APC PCDH7 SMAD4 LAMC2 PMC9009290__F9 Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis CDK2 CDK4 BAX PMC3849657__F1 YAP/TAZ are effectors of mechanical stress, GPCR signaling, and the Wnt signaling pathway. Mechanisms of YAP and TAZ regulation by mechanical stress, GPCR signaling, and the Wnt pathway as well as YAP/TAZ as modulators of the Wnt pathway are shown SOX2 BIRC5 AREG TBX5 ASCL2 BCL2L1 LATS1 YES1 RHO LPA LATS2 PMC2948275__F1 Putative functions of caspase-2 ATM CCNB1 CDC2 ATR BAX PMC2100434__F2 Growth hormone-mediated JAK/STAT signal transduction SOCS2 GHR PMC9318484__F2 Natural Products and Their Multitargeted Approach to Treat Solid Cancer TSC2 BAD TSC1 PTEN EIF4E MTOR IRS1 FOXO1 RHEB PMC4196962__F6 Interleukin-1B Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes PTCH1 CCL20 SHH SMO CXCL2 CCL2 IL1B PMC7211213__F3 Therapeutic targets associated with activation of the Wnt signaling pathway APC GPR49 TF PMC7643360__F5 Summarized diagram proposing that IGFBPs secreting PD-MSCsPRL-1 are the key antiadipogenic factors inhibiting adipogenesis in OFs from GO patients through upregulation of FAK and downregulation of the PI3K/AKT/mTOR signaling pathway PTEN DEPTOR IRS1 PMC6813133__F3 ADHD gene-networks constructed with PASCAL associated genes and its FunCoup interactors TCP1 MED4 ANAPC2 CCNB2 GMNN AURKA PMC6088210__F1 TLRs mediated the T cells response and programmed cell death process toward tumor environment TBK1 TH TRADD FOS TRAF6 IRF3 CD80 MYD88 FADD TIRAP PMC7760785__F2 Crosstalk between the major signaling pathway regulating autophagy and liver tumorigenesis TSC2 ULK1 TSC1 APC GSK3B PTEN BNIP3 TNF DEPTOR RHEB PMC2667769__F5 Defective respiration of Δisc1 in the post-diauxic phase COX2 ATP6 CIT PMC5445208__F6 Genes involved in B-cell receptor signaling which converges to mitogen-activated protein (MAP) kinase pathway, nuclear factor KB (NFKB) pathway, and phosphoinositide 3-kinase (PI3K) pathway are the therapeutic targets of B-cell lymphomas BTK PI3 CARD11 BCL10 SYK MTOR CD79B CD79A PMC8350857__F2 Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research EPO SESN3 EGFR GSK3B GATA6 BNIP3 MTOR HSF1 PMC5161407__F4 Nuclear DNA damage signalling to mitochondria in ageing ULK1 BAD ATG101 TSC2 CASP3 PINK1 ATM APAF1 DRAM1 CASP9 SIRT1 CASP8 FADD BAX PMC7211213__F1 Simplified overview of canonical Wnt signaling pathway activation APC GSK3B PMC6586148__F6 SHP2–ERK1/2 inhibition and STAT3 activation by Sunitinib ITGA7 MYOG PMC6190667__F8 Carbon contribution of medium ingredients to riboflavin based on combined parallel 13C-labeled tracer studies using [13C2] glycine, [13C] formate, [13C5] glutamate, and [U13C] yeast extract FAP GIP MAL PMC8833570__F1 KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders PLCG2 MTOR CD79B CD79A NF1 BTK BCR BASH LYN MDM2 GRB2 SYK CD19 PMC3328893__F1 Physiological and pathophysiological stimuli regulate tonicity-responsive enhanced binding protein (TonEBP) in diverse cell types IL16 BMP2 PMC7484670__F6 MTOR-miR-143 signaling axis in the pathogenesis of AD IL13RA1 FLG IVL PMC4026357__F1 Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy ERBB3 PMC8850641__F9 Identification of Potential Blind-Side Hypermelanosis-Related lncRNA–miRNA–mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Cynoglossus semilaevis) DCT TYRP1 PMC8137895__F1 Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases AGO2 DGCR8 DROSHA RAN PMC6457262__F1 Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity HEL-S-90n KMO PMC6611005__F9 Anti-pancreatic cancer pathway of Wumei Pill EGF IKBKG CHUK BAD TRADD EGFR MYC TRAF6 BCL2L1 MYD88 HIF1A KDR MDM2 CASP9 JUN PTGS2 TNF IKBKB CASP3 NFKBIA NFKB1 CDK2 RELA GRB2 BCL2 TRAF2 FADD PMC5233600__F1 NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection NLRP3 IL16 IRAK4 MYD88 AIM2 PMC8966686__F10 Integrative Transcriptomics and Proteomics Analysis Provide a Deep Insight Into Bovine Viral Diarrhea Virus-Host Interactions During BVDV Infection CASP6 IRF7 IFNE DHCR24 TRAF3 MAP3K7 TRAF6 IRF3 IL6 MAP2K3 MTOR CASP10 IFNG CASP3 NLRP3 SERP2 SCD DHCR7 IFNK JUN FADD MAVS FASN PMC3744088__F6 Extent to which glutamate (GLU) is oxidized in astrocytes seems to increase particularly during higher glutamate concentrations PC CIT MAL PMC12188105__F1 Glutamine signaling pathway and metabolism in cancer HEL-S-26 GOT2 TFEB GPT2 SLC7A11 MYC GLUD1 GLS PMC6886699__F9 Adenoviral Transduction of EGFR into Pregnancy-Adapted Uterine Artery Endothelial Cells Remaps Growth Factor Induction of Endothelial Dysfunction EGF EGFR GRB2 VEGFA SRC TRPC3 PMC7374824__F1 TLR signaling TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 TIRAP PMC2311275__F4 Following biological functions (central carbon pathway, redox and respiration coordination, phosphate starvation, nitrogen gestion, carbohydrates, nucleotide and amino acids metabolism, ribosome activity) PC HAMP CAST COPA CIT MAL PMC12188105__F4 Targeting glutamine metabolic reprogramming in cancers SLC7A5 PIG59 GOT2 SIRT4 FOXO3A GPT2 SLC7A11 EGFR MYC MTOR EGLN1 SLC38A1 PMC12188105__F2 LncRNAs regulate glutamine metabolism in cancer ATF4 TUG1 HIF1A GLS PMC6504851__F2 Diagram showing differentially expressed genes in BXW-resistant and BXW-susceptible genotypes of banana after inoculation with Xanthomonas campestris pv MYB FER MSC ERF PTEN PMC3261702__F4 Structural coverage of the core vision pathway and its links to other functional modules CNGA1 TUBA4A ACTN1 GRK1 MYL1 RALA ART3 RHO MYH10 MYH1 TUBA1C GC ARF4 SPTAN1 ACTN4 RAB13 TUBB SAG ACTN2 RALB GAP43 PRKD1 PDC MAP2K1 PRKCB ARL1 RCVRN RGS9BP RP2 TUBA1B ARF6 CAMK2A PDE6D PMC5821407__F4 Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases CS NDUFV2 HEL-S-30 NDUFA7 HEL-S-97n HEL-S-87p HEL-S-128m COX5A GPX3 UQCRC1 NDUFB7 ACO2 HEL-S-44 COX6B1 PGAM1 NDUFS8 HK2 HEL-S-281 SDHB PMC37430__F1 Simplified steps of Okazaki fragment maturation during DNA lagging strand synthesis (for further details see refs RAD52 DNA2 PMC8894711__F2 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection CGAS STAT2 CCND1 PMC8894711__F1 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection PDC IRAK1 TRAF6 IRF3 IRAK4 RAC1 MYD88 CASP8 FADD TIRAP PMC12123228__F2 Proposed mechanisms of BTKi-induced hypertension BTK NOTCH1 CD40 ARHA PMC3973006__F8 Schematic model of TGFB signaling pathways for CRP2 induction in VSMCs SMAD2 ATF2 CSRP2 SMAD4 ARHA PMC12123228__F1 BCR signaling pathway and mechanism of action of BTKi BTK BCR BASH LYN SYK PLCG2 MTOR CD19 PMC5952256__F1 The mechanism of extracellular vesicles (EVs) release differs among different types of EV LIMK1 ARF6 PMC3469596__F8 Neutral lipid and phospholipid biosynthetic pathways PC PLIN1 LDLR LPA TG PMC8375160__F10 Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/Beta-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells TCF4 BAX PMC7167271__F11 Effect of RPMP and emodin on genes expression profiles TG ACOX1 PMC5584530__F8 Cell surface HSPGs consists of a protein core linking several linear heparan sulfate (HS) chains APC LRP6 CDK8 CTGF PMC2921605__F1 PIK3/Akt/mTOR Pathway PTEN EIF4E MTOR PMC3022184__F2 A proposed mechanism of TGFA/EGFR/ras-MAPK activation loop in HNSCC EGFR TGFA CBL PMC7307792__F4 Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei PRODH PMC7564912__F8 Diagram indicating the mechanism of IITZ-01-induced TRAIL sensitization USP9X FADD CBL PMC6082928__F3 LMP1 in the carcinogenesis of nasopharyngeal carcinomas ATM EGFR JAK3 CSA2 STAT3 PMC11829765__F8 Lineage diversification in the ureteric mesenchyme MYOCD SHH ALDH1A2 WNT7B BMP4 PMC8889569__F4 Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells KPG_010 LPAR2 LPA MTOR LPAR1 LPAR3 LPAR4 PMC6082928__F6 Signaling pathways engaged by the LMP2A gene BCR GSK3B PMC4766172__F1 Lysine degradation pathways in mammals DHTKD1 PIPOX AADAT AASS ECHS1 GCDH PMC6191511__F1 Functional analysis of genes differentially expressed in response to L-lactate after 1 h TH MAX NFKB1 MAPK7 CA14 EVI1 CREB1 PMC6530608__F1 Mitochondria and ER in activation of the NLRP3 inflammasome NLRP3 CMPK2 AIM2 PMC3617401__F2 Emerging actions of the nuclear receptor LRH-1 in the gut CCND1 TCF4 CCNE1 PMC9195630__F10 Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143 MMP14 HK2 PMC5839790__F1 Classic autophagy compared with related trafficking pathways HMGB1 ULK1 ATG3 ULK2 SNAP29 SNAP23 DKFZp686F0183 IL16 KIAA0226 STX4A SEC22B STX3A UVRAG STX17 ATG14 VAMP8 PMC2992267__F8 A schematic model showing the proposed biosynthetic pathway for cutin GPAT4 LPA PMC6912224__F2 SMAD- and Non-SMAD-dependent TGFB signaling RHO MTOR TF PMC11855511__F8 Construction of DEmiRNA-mRNA expression regulatory network based on JAK-STAT signaling pathway and phagosome XK PMC7864954__F6 miR156-based regulation of SPL13 enhances photosynthesis, phenylpropanoid, and ABA biosynthesis in response to flooding MYB PC GCG PMC7919044__F2 G protein-coupled receptor (GPCR) kinase 5 (GRK5) activities within cardiomyocytes, cancer, and neuronal cells EGF EGFR SRC BCL2 HBEGF NFATC3 PMC5811627__F1 Outline of main altered pathways in pancreatic neuroendocrine tumours FLI1 PALB2 DEPDC5 VHL ARID2 PSPN PTEN MTOR BRCA1 EWSR1 KMT2C TSC2 CHEK2 TSC1 SMARCA4 BRCA2 MEN1 RAD51 MUTYH SETD2 PMC4415242__F8 The three axes of the UPR in Drosophila brains activated by HTorAΔE ATF4 EIF2A XBP1 PMC4234565__F3 Circadian pathways PIK3R1 IGF1R ERBB3 VEGFA DTX4 MTOR FLT1 ERBB4 IGF1 KDR ERBB2 IL7R CD19 PMC8072385__F2 Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein HMGB1 REL MTOR DKFZp686F0183 CD24 PMC9320351__F3 Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets NR1i1 CYP24A1 RXRA PMC5362547__F2A Hippo signaling pathway provides novel anti-cancer drug targets AMOT NF2 LATS1 RHO MOB1A MOBKL1A LATS2 PMC8909913__F1 Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets AFP PATJ SOX2 AMOT APC SMAD4 SMAD1 PMC7456423__F6 Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway SRC SKI PMC3720596__F1 NRAS mutant melanoma – undrugable? NRAS CCND1 MTOR CDKN2A PMC6346552__F9 Proposed molecular model of non-coding RNAs involved in CXCL12/CXCR4-induced CRC invasion and progression CXCR4 RHO CXCL12 PMC9204587__F1 Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression FDPS ABCA1 HMGCR PMC8533474__F5 Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet BHMT2 HEL-S-182mP ACOT8 GPX4 BCAT2 GPT GPX1 ACSS3 ACSS2 MTHFD2 ACSM5 MPV17L GPT2 SLC6A12 PRDX5 MCCC2 CTH LOC51064 MTHFD1 PHGDH ACSM3 PRODH SLC27A5 HEL-S-51e ALDH2 MTHFD1L LCT PMC7577395__F2 Representative contributions of ion channels to glioma cell proliferation MTOR TRPM7 PMC6592760__F2 Metabolic regulation of cell growth and proliferation PSAT1 ATF4 ASNS PHGDH RHEB PMC9009531__F1 Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis FACL4 CPT2 ACSL3 ACSM3 HEL-S-5 PMC8063501__F2 DSB repair pathway choice POLE RIF1 SHLD3 BRCA2 SHLD2 SHLD1 RAD52 RAD51 PARP1 LIG1 BRCA1 PAXX PMC11357158__F2 TGFB1/Smad pathway mediated by identified ncRNAs SMAD2 LEFTY2 FSTL1 SMAD4 TUBD1 COL1A1 PMC11357158__F1 Biological pathways and interactions of three ncRNAs DGCR8 DROSHA PMC3267157__F2 P73 pathway and its regulators.A simplified view of the p73 pathway, of its regulators, and of the molecules that directly or indirectly can modulate its function TSC2 PIN1 TSC1 ATM MDM2 PRIMA1 MTOR ITCH PMC11357158__F3 Hippo and Hedgehog pathways mediated by identified ncRNAs TEAD3 KIF7 SUFU PTCH1 TEAD4 SMO LATS1 MOB1A FBXW7 ADRBK1 TEAD2 PMC4232283__F8 Proposed working model NT5E ENTPD1 PMC11357158__F5 Wnt/Beta-catenin pathway and associated ncRNAs APC LRP5 LRP6 PMC9100112__F9 Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression LIF STAT3 PMC3498840__F1 TLR signaling overview: the TLR family can be subdivided into two categories TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 TIRAP PMC12013188__F14 Signaling pathways regulating the HAG MMP10 KEAP1 EGFR TRAF6 HBEGF MYD88 TNF ADAM17 NLRP3 TLR4 NOD1 CSA2 STAT3 BAX PMC4993044__F3 Proposed sequence of events following aberrant fatty acid reabsorption at the apical surface of the proximal tubule in the setting of nephrotic syndrome CPT1A ALB ACSL1 TG PMC2522278__F2 Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System EGF ATF2 EGFR APC GSK3A RAC1 STAT1 FLT1 FGFR1 AXIN1 GRB2 RHOF MAPK1 SIAH2 JUN SHC1 ARAF RHOB TCF4 CDC42 EXOC2 PMC2682371__F2 ErbB proteins are type I transmembrane receptor tyrosine kinases ERBB4 FOS ERBB3 SOST EGFR MYC SRC MTOR AK1 STAT3 PMC8712868__F2 Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases TSC2 MFF RUNX2 FGF18 MTOR IL1B FOXO1 RHEB PMC4889588__F1 Schematic depiction of oncogenic MYC signal transduction MAX FOS MYC PTEN EIF4E MTOR JUN PMC4591983__F6 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula STAT1 SCG2 COX2 GRIN1 IL1RAPL2 TFAP2A NR1H4 PRL STAT3 PMC4936107__F1 (Left) Model for sulfur assimilation FES CBL PMC4591983__F5 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula IL16 EPCAM NPR3 BIRC5 MAP3K14 HAND1 FAT10 DNAJB7 TNF INSL4 PMC4432002__F2 Role of the BM niche in MM pathogenesis CCL2 IL4 CXCL12 TGFA BPI POLI PMC4049967__F1 IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF) IL17A JAK3 STAT3 PMC6816428__F1 Crosstalk between the Hippo pathway and Multi-vulval class B (MuvB) complexes E2F4 LATS2 DYRK1A PMC8817131__F3 PGC‐1A protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication NRF1 POLRMT NQO1 PMC3991464__F1 Four pathways of androgen metabolism AKR1C2 CYP17A1 PMC5789791__F1 Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model TG SCX PMC8105286__F1 Biophysics of Notch Signaling EGF RBPJ ADAM10 PMC6436556__F3 A model showing how the cargo in exosomes can potentially change RAB35 EGFR SYT7 PMC9255252__F1 Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication SUFU APC JAK1 PMC8036803__F2 Msi1 impact on cell cycle and division CDK5RAP2 CDCA5 CCNA2 E2F4 RPA3 FANCD2 BIRC5 SPC24 SMAD2 SMAD4 PRIM1 RBBP8 SMC1A TIMELESS FGFR1 POLA1 POLA2 TOPBP1 MSH6 MDM2 EZH2 ORC6 APC CENPE CDC25B BRCA1 CDC45 STAG2 CLSPN CDC20 MCM2 SUV39H1 CDC6 KIF18B BRCA2 CDK2 TP73 TUBA1B C13orf34 CDT1 DNA2 PCNA MSI1 BLM IPO5 TOP2A DBF4 ORC3 TUBB2A ORC2 ATAD5 CDK7 FEN1 PRC1 E2F2 RRM2 WDHD1 ESCO2 CDC2 PRKDC RBL1 CCNE2 NUSAP1 CRY1 CBX3 RPA1 MAD2L1 INCENP RCC1 STAG1 CHEK1 AURKA POLD3 RFC3 UBE2C TUBB4B BUB1B SMC3 WDR76 NCAPG CCNB2 HEL164 ORC1L DCLRE1B SMC4 SKP2 ESPL1 NCAPD3 MYT1 PMC7923925__F1 The Hippo Pathway in Breast Cancer Carcinogenesis, Prognosis, and Treatment: A Systematic Review TEAD3 NF2 MYC CCND1 AJUBA MARK1 TEAD4 AXL TEAD2 PMC8807040__F8 Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway CDK4 CDK6 STAT3 BAX PMC5620328__F1 Long non-coding RNAs associated with non-small cell lung cancer EGF EGFR MTOR PMC8378993__F1 Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm CNTF LIF IL11 OSM STAT3 PMC9558278__F2 Identification of key gene networks controlling polysaccharide accumulation in different tissues of Polygonatum cyrtonema Hua by integrating metabolic phenotypes and gene expression profiles GMDS UGDH PMC5346727__F3 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method IKBKG PPP3CA EGFR CYLD ADM JUN MAPKAPK2 CAMK2D FOS CAMK2G MAP3K5 EIF4E CDC25B HRAS CRK DDIT3 HEL-S-69p HEL-S-102 MAP4K2 NFATC2 PPP3R1 MAP2K1 JUND TF PIK3R2 PMC1905373__F7 Mechanism of complement-dependent haemolysis via the lectin pathway: role of the complement regulatory proteins HEL-S-62p C1S PMC10816532__F3 Potential mechanisms underlying the inhibitory effects of magnesium on vascular calcification CASR TRPM7 PMC7432830__F4 HSP90 involvement in TGFB signaling cascade SMAD2 SMAD4 PMC5346727__F5 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method IL3RA E2F4 IKBKG MYC PANK1 GADD45B CYLD IL7R JUN IL1B GDF6 FOS SMAD6 CDC25B HRAS IFNAR1 GATA4 NFKB2 MAP3K2 NFKB1 TNFRSF1A NEK2 TRAF2 TF STAT3 PMC5346727__F4 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method E2F4 IKBKG PPP3CA MYC PANK1 CYLD ADM JUN GDF6 MAPKAPK2 SMAD6 CDC25B HRAS DDIT3 GATA4 HEL-S-102 MAP4K2 NFATC2 RAP1A NFKB1 TNFRSF1A NEK2 JUND TRAF2 TF PMC9355870__F7 SLC35B2 is a vulnerability in YAP1-driven MAPKi-resistant, BRAF mutant melanoma YAP1 ERBB3 EGFR SLC35B2 HBEGF NRG1 AXL PMC11748510__F10 Scheme summarizing the inhibitory effect of baicalein on PRRSV infection GP5 EGFR SRC PMC7902093__F3 Environmental mechanisms of orofacial clefts CASP3 BMP2 FGF10 SHH GATA6 BAX PMC2731267__F1 Some putative molecular mechanisms that underlie the antineoplastic activity of mesalazine APC EGFR PMC7902093__F2 Environmental mechanisms of orofacial clefts AIP AHRR AHR RUNX2 NR3C1 SRC DES TGFA PMC2912554__F6 Tumor suppressor pathways control Mdm2 function SMAD2 MDM2 CDK4 CDK6 PMC7902093__F1 Environmental mechanisms of orofacial clefts NOTCH2 AHR MSX1 NOTCH1 MSX2 LHX8 PMC5501134__F5 Complex and context dependent functions of the Slit/Robo signaling in angiogenesis SRC ROBO4 ROBO1 RHO RAC1 SLIT2 ARF6 PMC6002803__F1 Reciprocal Signaling Between Translational Control Pathways and Synaptic Proteins in Autism Spectrum Disorders TSC2 TSC1 PTEN EIF4B RHEB PMC9421970__F2 microRNA expression in acute myeloid leukaemia: New targets for therapy? SOCS2 ATL1-beta NRAS MEIS1 PTEN MTOR FBXW7 CDK6 GATA1 CAMKK1 CCND2 DICER1 F3 MAPK1 HMGB1 HOXA9 FOXO3A BAK1 CTDSPL KLF5 SPRED1 MAP3K10 FOXO1 TET2 E2F7 MAP2K1 MCL1 HEL-S-93 SIRT1 PMC6320978__F1 Schematic overview of the Nucleotide Excision Repair (NER) pathway ERCC1 XPA PCNA PMC6405523__F4 IIP-effectors in FOXJ1 regulatory network and their probable ciliary associations FBF1 PRKCZ SOCS3 FLNA BBS2 GSK3B MYC MAPK14 FOXJ1 DLG4 TERF2IP PRPF31 ATXN1 HTT DAB1 SP1 ATXN10 DYNLL2 DNAAF19 PARD3 APOE MEOX2 PACRG BAIAP2 APC ACTN2 VDAC3 CDC20 HEY2 GRB2 EXOC4 VCP TERF1 TOPORS CP CDC42 TBK1 IKBKG BTRC EEF1A1 RHO UBC IFT57 BBS4 BIRC3 NLGN3 APP PARD6A NPHP3 CEP164 SKIL STOM VHL SKP1 RIPK3 FKBP5 INTU NME7 BIRC2 EP300 TRIM32 MAP3K2 OGT RELA TRAPPC9 ACD FAM161A FADD SKP2 PMC6317572__F2 Common downstream targets for cancers of the breast (blue dots), colon (green dots), lung (red dots), and prostate (brown dots) CDKN1A CDKN2B ATM CDK2 CDKN1B GSK3B SMAD4 CDK4 ATR CDKN2A CDK6 SKP2 PMC4089452__F2 Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease TSC2 TSC1 GSK3B MYC SRC PTEN SIRT1 PMC4003878__F2 GSK3B and the control of infectious bacterial diseases GSK3B JAK3 TNF PMC7911491__F3 Effects of squalene in the NF-ƙB pathway CD14 MYD88 IL1B PMC9575701__F3 An emerging role for cellular crosstalk in the cancer stem cell niche SMAD2 IL33 SMAD4 PMC3836174__F5 Hallmarks of Aging IGF1 PTEN MTOR SIRT1 PMC9575701__F1 An emerging role for cellular crosstalk in the cancer stem cell niche TNC HEL-S-28 NRP1 LIF PTGS2 VEGFA TEC IL1R1 FOXP3 PMC8813987__F9 Pathway that signal prolonged cutaneous allodynia elicited by CGRP released and associated with neurogenic inflammation TRPA1 RAMP1 TRPV1 PMC7288655__F9 TGFB signaling pathway BAMBI FST NODAL FRK PITX2 TGFBR1 SMAD4 SKP1 ARHA IFNG PMC9549367__F1 Irisin in physiology and pathology NLRP3 BMPR2 TIMP1 TIMP3 ADAM10 MSTN PMC3541267__F3 Signaling pathways driving mesenchymal stem cells to differentiate into lineages found in reparative disorders TGFBR1 RYK WNT5B WNT10B PMC6774117__F10 NGF-driven differentiation of PC12 cells requires a signal(s) generated from the UPAR immediate-early gene product EGR1 PC NGF PMC4346319__F2 HIF Transcription Factors, Inflammation, and Immunity SEMA3A IL6 NOS2 IFNG PMC5161754__F7 EGFR activation during CRC progression through demethylation and subsequent upregulation of EREG at the adenoma–carcinoma transition EREG APC EGFR PMC10671577__F3 MAPK signaling pathway containing T CD14 EGF CHUK BRAF MOS PDGFRA EGFR CDC25B TNF TOB2 FGF9 MAX GRB2 ECSIT TRAF2 AKT3 PMC7917723__F1 Absorption, and excretion pathway of gut-derived uremic toxins SULT1A1 HEL-S-70p CYP2E1 PMC9313309__F2 Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition COX2 APC S1PR1 SPHK1 STAT3 PMC5991449__F3 Overview of the pathways involved in odd and even fatty acid production including the link with the TCA and methyl citrate cycles in Yarrowia lipolytica ACO2 HEL60 PMC7586293__F2 |Central metabolic pathways are driven not only by post-transcriptional changes but also by the adaptation of protein concentration upon the induction of insulin resistance ACACA PTPN1 FH GSK3B ACO2 OGDH SH2B2 MTOR RPTOR FOXD1 RHEB PMC6476316__F4 Mutations in the bone morphogenetic protein-signaling pathway are linked to hereditary hemorrhagic telangiectasia and pulmonary artery hypertension BMPR2 ACVRL1 DROSHA SMAD4 ENG SMAD9 PMC10313365__F8 Roadmap of molecular changes and cellular phenotypes when cells lose MLL3/4-COMPASS DPY30 WDR5 NCOA6 ASH2L PMC11012155__F1 Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer AIP AHR CYP1B1 CYP1A1 KLF6 PMC8499523__F6 Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide IKBKG CCNA2 F2R CDKN3 CCL21 FBN1 POR RPSA IFNG AHR DEFA3 CSF2 CCL8 EGR1 TCF3 PLAUR PRKAA2 CXCL10 ADFP S1PR1 ITGB1 SERPINE2 IFI27 GATA2 HLA-A IDO1 CACNA1H NFKBIA HMMR EGR2 CXCL9 SUSD2 TRAF3IP2 CD93 NXPE2 P2RX4 ECRG4 PMC4419739__F4 Cellular and signaling pathway view of gene expression changes during alcohol withdrawal ME1 JUN PMC3267732__F4 Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA Pathway Dominates a Subsurface Ecosystem POR HEL107 RPE PMC3912487__F1 The sphingolipid rheostat in AD context BACE1 IGF1 HDAC2 SPHK1 SPHK2 HDAC1 PMC8072960__F3 Androgens and Androgen Receptor in Human Bladder Cancer MMP3 CXCR1 IL8RB SRD5A2 EIF4E PMC8072960__F1 Androgens and Androgen Receptor in Human Bladder Cancer SHBG SRD5A2 PMC12024137__F4 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review EGR1 ATF4 EIF2A PMC4442386__F8 Model for the overall disruption of IFN responses by SFTSV through NSs hijacking of signaling proteins in IBs TBK1 STAT1 STAT2 IRF9 IRF3 PMC6262249__F2 Role of macrophages in hepatitis C virus infection-associated inflammation NLRP3 TLR8 TLR7 IL6 MYD88 TLR1 IL1B PMC9466593__F1 Effect of antifungal resistance development on the virulence of Candida species CDR2 ALB PMC6831489__F5 Schematic summary of the responses on energy metabolic pathway reprogramming by genotoxic or non-genotoxic hepatocarcinogens in rat liver cells MPC2 ATP5IF1 GLS PMC12024137__F3 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review PDX1 TNF IRS1 FOXO1 PMC8846368__F2 Targeting Nutrient Dependency in Cancer Treatment MTAP KEAP1 SLC7A11 MYC PIK3CA BAP1 PMC8846368__F1 Targeting Nutrient Dependency in Cancer Treatment SLC7A11 ASNS ASS1 ASL GLS PMC4378640__F4 Schematic presentation of chloroplast proteins affected in executer mutants and WT plants after light treatment compared to WT plants under normal or growth light conditions, as shown in Table 3 PC TPR RPE PMC4982039__F1 Hypoxia‐induced changes in mitochondrial metabolism HEL-S-26 PC ADSL ACO2 CIT HEL60 MAL PMC8894956__F4 First-line immunotherapy or angiogenesis inhibitor plus chemotherapy for HER2-altered NSCLC: a retrospective real-world POLISH study TBK1 CGAS IRF3 IFNG PMC9508558__F8 Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma CES2 MYC PMC6375688__F1 Proteostasis regulation ATF4 EIF2A PMC6487307__F1 Polyamine metabolic pathway ADI1 SMOX SRM PAOX SLC3A2 AMD1 SMS HEL-S-18 PMC8186080__F7 Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression ATG16L1 ATG12 MTOR PMC5882219__F3 Reciprocal regulation of YAP by TRIO-RAC1 signaling and the Hippo pathway RUNX3 RAC1 TRIO PMC3056141__F1 DNA-mediated activation of innate immune signaling TBK1 IL13 TRAF3 IRF3 AIM2 FADD PMC4885841__F6 Schematic diagram demonstrating the immunomodulatory and therapeutic effects that grafted stem cells exerted on the recipient upon transplantation EGF TLR4 NGF MSC GDNF BDNF TLR3 PMC9209741__F3 Medulloblastoma and the DNA Damage Response BAD ATM MDM2 PTEN ATR PMC7847335__F1 Toll-like receptor-signaling pathway during pulmonary infections IL16 TLR4 CSA2 TIRAP PMC3173728__F1 In this figure we show the two main pathways to apoptosis, and their interaction through the molecule BID, since death receptors activate the intrinsic pathway by activating BID APAF1 BCL2 FADD BAX PMC2862880__F3 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer HSD3B1 CYP11A1 AKR1C1 SRD5A2 AKR1C2 CYP17A1 HSD17B6 PMC7199629__F2 Regulatory mechanisms and biological functions of MTHFD2 in cancer ATF4 MTHFD2 SOX7 PMC4651701__F1 Targeting IL4/IL4R for the treatment of epithelial cancer metastasis IL13RA1 TYK2 JAK3 JAK1 IL4 MTOR IRS1 PMC4825019__F5 Ingenuity pathway analysis identifies two highly enriched networks for the Tau-interacting proteins CS HEL-S-11 HEL-S-77 PMC4347943__F1 wRAPping up early monocyte and neutrophil recruitment in atherogenesis via AnnexinA1/FPR2 signaling FPR2 CCL5 CCL2 PMC8782720__F8 Proposed model of the role of DAB2IP’s phosphorylation in SAC maintenance and cancer development suppression CDC20 APC DAB2IP CDC2 PMC3588168__F1 Simplified schematic of signaling pathways driving resistance to BRAF inhibitors IGF1R BRAF PTEN ARAF PMC8472725__F1 Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association LAMP2 EEA1 PMC6277637__F11 Inflammatory pathways in osteoarthritis TH PTH IL1B PMC7497193__F1 Two major signalling pathways implicated in melanoma PLCB4 NF1 KIT KPG_011 EGFR GRB2 MTOR PMC6560203__F3 Hydrogen sulfide interaction and effects upon the activity of its biological targets KEAP1 HEL-S-11 RPS3 ATR PMC9032563__F1 Mapping Molecular Networks within Clitoria ternatea Linn. against LPS-Induced Neuroinflammation in Microglial Cells, with Molecular Docking and In Vivo Toxicity Assessment in Zebrafish VASP ARHA RHO PMC7195008__F1 Pathophysiologic Model of Immunothrombisis in COVID-19 ACE2 TF PMC4324508__F1 Microbiota modulation of myeloid cells in cancer therapy HMGB1 TLR4 TLR9 RB1 TNF ATR IFNG BAX PMC9372905__F1 Rare Variants in the Norrin-FZD4 Signaling Pathway and Familial Exudative Vitreoretinopathy (FEVR) With Extraocular Phenotypes TSPAN12 APC GSK3B LRP5 FZD4 NDP PMC5052620__F10 Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGFB pathway in precancerous Oral Submucous Fibrosis SMAD2 ATF2 BMP7 THBS1 JUN PMC2719559__F2 Paracrine and autocrine mechanisms of Akt-mediated tumor-stromal interactions CCR5 IGF1 CXCR4 CCL5 PMC4156720__F1 Cotargeting the PI3K/AKT and AR pathways in CRPC FKBP5 PTEN MTOR PMC6272897__F5 Putative pathway for the inhibition of inflammatory signaling events by AQCA in in vitro inflammatory responses TLR4 IRAK1 ATF2 SRC SYK MYD88 PMC8670943__F1 Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress ATF4 EIF2A CHAD PMC6233323__F1 Integration of Drosophila and Human Genetics to understand Notch signaling related diseases NUMB MIB1 CDK8 PMC7753942__F2 Summary of immunopathogenesis in early and late SARS-CoV-2 infections STAT2 IRF9 IRF3 TYK2 JAK1 ACE2 MAVS PMC9428632__F4 Roles of glycolysis in osteosarcoma EGFR ROR2 MTOR PMC7398066__F2 ABC transporter-related signaling pathways TLR4 PC IGF1 ABCG8 CRH ABCG5 GPS2 ABCA1 FOXO1 PMC5034715__F4 Metabolomics analysis of hormone-responsive and triple-negative breast cancer cell responses to paclitaxel identify key metabolic differences MAP2 CYP1B1 MAP4 CYP3A4 ABCG2 ABCC2 PMC8377944__F1 Secondary hypertension: An update on the diagnosis and localisation of a pheochromocytoma or paraganglioma TH PNMT PMC9145792__F9 Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling HGF MTOR BAX PMC7601870__F2 Crosstalk between CK2 and signaling pathways (A) regulating fatty acid synthesis or (B) controlled by phospholipases TSC2 USF1 PLD2 SCD LDLR ACLY SP1 ARF6 RHEB FASN PMC11792405__F3 TSC1-TSC2 complex in ovarian GSCs, Nephron progenitor cells and ISCs ZNRF3 TSC1 APC MYC LRP6 PMC9707069__F2 From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling BOC KIF7 RUNX2 SUFU SMO ARHA GAS1 RAC1 PMC3684428__F2 IRE1Alpha- and PERK-mediated cell death pathways ATF4 EIF2A BCL2 ATF3 TRAF2 PMC3684428__F1 The adaptive unfolded protein response (UPR) ELF2 ATF4 EIF2A XBP1 TF PMC8494682__F1 Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway PPCS ERG NUS1 PPCDC PMC7854640__F7 Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution NOTCH2 CXCL13 CX3CR1 LAMP3 CX3CL1 EGFR CCR4 CXCR5 PMC9441498__F6 Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma CCND1 PTEN PMC9596393__F4 Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review HEL-S-133P PMC2794560__F1 Metabolic pathways of tamoxifen CYP2C9 CYP2C19 PMC4367126__F1 Induced regulatory T cells in inhibitory microenvironments created by cancer COX2 PDC NRP1 LAG3 FOXP3 PMC4926327__F7 Mechanism of stimulated VSMC proliferation through the Wnt4/Dvl-1/Beta-catenin signaling pathway WNT4 APC FZD1 PMC5332939__F1 Diagrammatic representation of the EGF signaling pathway EGFR GRB2 STAR PMC3384069__F1 Wnt/Beta-catenin signaling pathway APC GSK3B PMC7381619__F1 Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression KEAP1 H1-0 GC FES PMC11852973__F3 Therapeutic strategies targeting the AIM2 inflammasome in cancer PDC CXCL10 FGF2 AIM2 PMC4285816__F6 A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS) ATF1 TRAF2 JUN STAT3 PMC11852973__F1 Tumor-derived double-stranded DNA (dsDNA), which can be derived by genomic instability, activates AIM2 inflammasome and cGAS-STING signaling pathway CGAS IRF3 AIM2 PMC3976626__F8 By simultaneously inhibiting CBS activity and inhibiting GOT1, a key enzyme of the malate/aspartate shuttle, AOAA acts as an inducer of ‘synthetic lethality’ in cancer cells GOT2 PMC7551862__F7 FO promotes bone formation and growth by activating the IGF-1/IGF-1R signaling pathway IGF1R IGF1 RUNX2 GSK3B PMC4255622__F1 Signaling pathways: HN exerts its function through both extracellular receptors and intracellular binding partners CNTF VSTM2L TRIM11 STAT3 BAX PMC3489928__F4 Proposed Reaction Pathway CS SI PMC9647168__F1 Modification of phosphoinositides by the Shigella effector IpgD during host cell infection TIAM1 EGFR PMC7042182__F8 Sketch map of the signaling axis with the most significant co-expression pattern including YY1 (Yin and Yang 1 Transcription Factor), Hepatitis A Virus Cellular Receptor 2 (HAVCR2) and mTOR signaling pathway CD14 LGALS9 HAVCR2 YY1 MTOR PMC11676689__F4 FoxO signaling KEGG pathway; (B) ABC transporters KEGG pathway TH ME1 ATG12 INS SMAD4 PTEN CMC4 PEMT NLK ABCB4 ATM CDK2 MDM2 KLF2 ARC ABCB10 BNIP3 SIRT1 GLA TF SKP2 ABCD2 STAT3 PMC10488162__F4 The Nrf2 signaling pathway in environmental pollutant-related ovarian aging MAF KEAP1 NQO1 PMC3071166__F3 Hypothetical scheme of the proposed mechanisms contributing to the induction of tolerance by SIT TFG PMC7092629__F2 Predicted protein-protein interactions in aSyn pathology: hypothesis and bioinformatic analysis SAP30BP AP2A1 ATP6V0D1 STX1A DNAJB1 HSPB8 P3H1 HSPD1 POLR2H GOSR2 UBB FBXW7 UQCRFS1 SLC25A12 SLC25A11 SIAH1 SLC25A13 AP2M1 UQCRC1 TAF7 HTT UQCR10 PPIL3 HMGB2 TFAM SNRNP200 UQCRQ SNCA PDIA2 UQCRC2 CBX4 NEDD4 SLC25A22 PARK2 HNRPA3 POLR2L HEL-S-123m HEL-S-100n RPS3 SIAH2 HSPA1A HEL-S-72p SYP EIF2S1 UQCRB DDX1 EIF5A AP1B1 EEF1A1 FKBP3 STX5A WDFY3 MEF2D UBC HEL-S-67p ENSA SYN1 FKBP4 ATP6V1A ATP5PB HMGB1 HEL-S-89n RPS14 RAB5A LRRK2 LAMP2 STXBP1 SNCAIP SNAP25 PRPF19 PINK1 SLC25A3 STUB1 ND2 PPIB MST065 RNF10 SYT2 RPS23 PMC10488162__F3 The Nrf2 signaling pathway in age-related ovarian aging MAF GPX4 CCNB1 HEL-S-44 SIRT1 NQO1 TF PMC2834432__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade TSC2 RICTOR BAD TSC1 MDM2 PTEN MTOR RHEB MLST8 PMC4009396__F2 microRNAs in cancer AGO2 DGCR8 DROSHA XPO5 PMC2721377__F1 Molecular toll-like receptors (TLRs) of the human gastrointestinal (GI) tract which act as sensors and are the first responders in the major pathway by which the immune system detects infection or damaged tissue CD14 TLR5 LTA TLR4 JUN PMC7432706__F2 Leptin receptor signaling pathway, and alterations in signaling that characterize various ganglioside-deficient KO mouse models POMC SOCS3 AgRP SH2B1 STAT3 PMC7432706__F1 Biosynthetic pathway of ganglio-series gangliosides UGCG B4GALT5 B4GALNT1 B3GALT4 ST3GAL5 PMC6710477__F1 Schematic overview of cytoplasmic 60S subunit assembly DRG1 DNAJC21 EIF6 EFL1 EI24 NMD3 SBDS LSG1 PMC10854734__F5 SADS-CoV infection induces apoptosis and complete autophagy ULK1 ALG13 CASP9 MTOR ATG14 CASP8 FADD PMC8964401__F7 Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling PDC CS HEL-S-304 DLD RPIA HEL107 RPE HEL-S-133P DLAT SDHA HEL-S-162eP PMC8103580__F1 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy APAF1 BCL2 CAD HEL-S-130P HTRA2 FADD BAX PMC8103580__F4 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy ULK1 ATG12 ATG3 AMBRA1 BCL2 ULK2 ATG10 ATG14 DKFZp686F0183 PMC8103580__F3 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy HMGB1 TLR4 TRADD TRAF5 CYLD IL33 RIPK3 TNF TRAF2 FADD MLKL TAB3 PMC7933775__F1 Hippo signaling pathway WWC1 NF2 AREG LATS1 MOB1A LATS2 PMC2956014__F2 Neutrophil apoptosis TRADD APAF1 MCL1 TNF TRAF2 FADD BAX PMC3565545__F9 BRCA pathway showing the role of BRCA1 in DNA damage response and crosstalk with other biological pathways, notably the P53 pathway.Notes: Double circles indicate complex interactions involving multiple genes PLK1 BLM MDC1 BARD1 ATF1 MRE11A BACH1 IFNG STAT1 ATM ATRIP MSH6 RAD50 MSH2 ATR PMC8860543__F8 TNFA Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells FOXO1 TF STAT3 PMC5081415__F4 KEGG analysis of STRING network of C CYR61 MSI1 PLB1 CIRSR PCK1 DKFZp686D2168 CCR4 MSL1 UXS1 URAD NRG1 PMC4539002__F1 Proteostasis network (PN) CANX HIKESHI BAG3 DKFZp686F0183 NBR1 PMC7176878__F2 NFKBIA is involved in the NF‐KB signalling pathway PLCG1 EGF NGF TRADD IRAK1 TRAF3 TRAF6 PLCG2 IRAK4 MYD88 COX2 BTK BCR ATM BASH CD14 LTB PARP1 TRIM25 LTA TRAF5 VCAM1 TRAF1 LCK LBP LYN SYK TRAF2 LTBR LAT TIRAP PMC4629839__F1 MTOR pathway TSC2 EEF2K RICTOR TSC1 PIR EIF4E MTOR EIF4B IRS1 RHEB PMC3439567__F2 P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation FLNA EGFR GRB2 APP SRC RHO PMC4523019__F2 Interferon signaling upstream regulator pathway, with subcellular compartmentalization indicated IFIT3 HEL-S-62p PLSCR1 CXCL1 IFIT2 APOL3 IFITM3 LGALS9 RTP4 BMF APOL1 CEACAM1 USP18 ISG15 GBP1 SP110 OAS1 OAS2 OAS3 TAP2 MMP2 RSAD2 LAMP3 SPRY4 IRF9 BST2 CHAC1 TNLG7A TLR3 C1QB TRIM14 CISH PARP12 APOL6 IGFBP4 CXCL9 SOCS1 HRK PSME2 PMC8513137__F4 Glucagon’s Metabolic Action in Health and Disease GCGR SIK2 PCK1 CRTC2 HEL-S-5 PMC3578033__F2 Inflammation and Diabetes-Accelerated Atherosclerosis: Myeloid Cell Mediators AKAP8 PC AKAP11 ACSL1 AKAP10 PMC3076854__F2 Global transcriptome analysis reveals CB1R-dependent, PHX-induced up-regulation of key cell-cycle proteins EGF ATMIN COMP PMC8647113__F11 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases ITK RHOD BAD GRB2 SHE DOCK2 PREX1 CDC42 PMC8647113__F10 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases CD14 MAX TRADD F2 GRB2 APP TRAF6 MIP GAL TNF TRAF2 APMAP PMC2958130__F5 Intertwining Threshold Settings, Biological Data and Database Knowledge to Optimize the Selection of Differentially Expressed Genes from Microarray CD14 TLR4 VCAM1 MMP9 LBP TRAF6 LY96 PMC8637208__F5 Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function FYN ARHA LATS1 LATS2 PMC10674800__F6 Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties in Taxus cuspidata Suspension Cells in Response to Elicitors MVD MVK IPP PMC11242595__F2 TGFB Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities SRC TRAF6 TUG1 STAT3 PMC8304794__F5 Transcriptomic Profiling of Femoral Veins in Deep Vein Thrombosis in a Porcine Model LTA HEL-S-11 APP STRAP TNF PMC3517905__F1 Summary of the signaling pathways of PKMζ-mediated late-LTP PIN1 PRKCZ HEL-S-30 MTOR BDNF PMC3923158__F2 Components that determine the establishment and tolerance-inducing capacity of tolerogenic effector DCs CD80 TNF VIP STAT3 PMC1856765__F7 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications CS ATF2 IL6 TNF FADD BAX PMC8504858__F2 Inductive Materials for Regenerative Engineering RUNX2 SUFU APC SOST GSK3B SMAD6 SMAD4 SMO ADAM10 SMAD1 DKFZp781O1323 PMC8874480__F2 JAK2 in Myeloproliferative Neoplasms: Still a Protagonist MPL STAT3 PMC3814363__F4 Structure-based phylogenetic tree of ATPase enzymes DMC1 ELP4 GET3 MMAA RAD50 RHO CFTR PMC6278419__F5 PPI network and module analysis FGA APOB HEL111 PLG APC ALB AHSG APOH AMBP PMC3583555__F1 Simple model for regulation of breast cancer initiating cells (BT-IC) self-renewal in breast cancer SUFU SMO BMI1 PMC9687165__F3 Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways CSF1R MAFB KLF4 SIRT1 PMC1856765__F3 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications FADD BAX PMC3583555__F2 Regulation of apoptosis by several pathways ITGB3 RTKN BAX PMC3433902__F5 Immune response to phagosome in antigen presentation network pathway map associated with the proteins identified as differentially regulated during zebrafish caudal fin regeneration ROCK2 VASP c-fgr CABP1 CD6 RALA ARHA CD74 CRKL PAK1 TRAM1 HEL-S-269 BASH VTN CRP GRB2 LBP ARF6 LAT ELMO1 PMC7483256__F2 Small-molecule drug repurposing to target DNA damage repair and response pathways XPC DDB2 LIG1 DDB1 PMS2 FAN1 POLE FAAP24 MSH6 FANCM RAD51 ERCC1 XPA MSH2 PCNA PMC8471347__F3 NFKB Nucleolar Stress Response Pathway RELA CCND1 CDK4 POLL POLI PMC8471347__F1 NFKB Nucleolar Stress Response Pathway RELA COMMD1 BAX PMC7580254__F9 Schematic diagram representing the role of Bruton's tyrosine kinase (BTK) in the pathophysiology of sepsis BTK CXCL1 IL1B PMC7483256__F3 Small-molecule drug repurposing to target DNA damage repair and response pathways POLE ATM BLM BRCA2 RAD51 RMI1 XRCC3 MRE11A WRN BRCA1 PMC12210561__F2 Gln modulates multiple signalling pathways to regulate cancer cell proliferation ASNS EGFR LATS1 EPHA2 GLS PMC7425451__F5 Downregulation of miR-135a on RAB1B and the RAS signaling pathway in NSCLC cell progression RAB1B ARHA RAC1 RAF1 PMC7297132__F1 Characteristics of astrocyte senescence HMGB1 IGF1 NGF GFAP IL6 H2AX PMC7346762__F2 TrkB signaling-mediated cell survival and the Nrf2-ARE antioxidant system MAF GRB2 BDNF PMC8234271__F2 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma RIT1 IGF1R BRAF ALK EGFR FGFR4 FGFR2 NF1 ERBB4 FGFR1 PTPN11 MAPK1 ARAF ROS1 NTRK2 KIT PDGFRA ERBB3 NTRK1 FGFR3 RAC1 HRAS CBL RET MAP2K1 ERBB2 FLT3 SOS1 PMC8234271__F1 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma KIT EGFR GRB2 PMC10340761__F4 Gene interaction pathways and their regulation in cancer EGLN3 BHLHE41 CA9 COXFA4L2 PMC8069355__F3 Speculative model of theta-mediated end joining (TMEJ)/Polθ activity as back-up repair of DSB in homologous recombination (HR) deficient cells POLE RAD51 BRCA1 PMC6629462__F1 Transport processes and regulatory mechanisms in A- and B- and non-A, non-B IC RHBG RHCG PC PMC6027519__F2 Regulation of innate and adaptive immunity by hypoxia and HIF signaling pathway IMPACT CXCL8 IL6 PMC11058607__F2 Pathways in HNSCC cells involving growth factor receptors like TGFB causing cell migration and invasion leading to metastasis TGFBR1 MAP3K7 TGFBR2 MTOR PMC7048923__F6 PPI network of “drug-compound-target-pathway” of cinobufotalin injection for lung cancer FHIT MPO PGR TYMP MTOR FGFR2 CHEK2 PRKCA HPGD KDR NR1i1 MMP2 PTK2B MDM2 SRC ELANE EZH2 AXL KIT DPYD PTGS2 VHL CA9 TNF AURKA CASP3 RET HEL111 EDNRA EP300 ADA TYMS PIK3CA BCL2 FLT3 SETD2 PPARG MME TERT PMC8847160__F1 Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy GPX4 TF PMC7763058__F1 TGFB signaling in fibroblasts LIMK2 SMAD2 SMAD4 RHO PMC3857155__F1 Basic depiction of the classical view of the PI3K signaling network (black arrows) as well as the novel signaling pathway revealed in the study by Tan et al PLK1 MYC PTEN MTOR PMC6343466__F1 The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis TYK2 JAK3 JAK1 PMC4111858__F5 Two-step model for OR-instructed axonal projection of OSNs KIRREL3 KIRREL2 NRP1 PLXNA1 PMC7969115__F3 Biomarkers play role in pathology of OA by multiple signaling pathways including NFKB pathway, MAPK pathway, Wnt-signaling pathway, and TLR pathway TLR4 VCAM1 ATF2 APC MMP9 LRP5 LRP6 IL6 PMC5854644__F9 MicroRNAs (miRNAs) related to the epigenetic control of genes involved in demyelination, epithelial–mesenchymal transition (EMT), inflammation, pain, and loss of sensation were differentially expressed in leprosy patient (LP) HOXB7 AQP1 ROCK1 ATP1A1 SMAD2 TGFBR1 MAPK14 SNAI2 CD44 ARHA RAC1 TRPV1 SOX9 HOXB5 ERBB2 ZEB2 HOXC8 ERBIN SOX10 RAF1 MEF2C JUN TGFB1 CDC42 PMC8394875__F3 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology ZNRF3 RNF43 APC GSK3B AXIN1 LRP5 LRP6 GPR49 AXIN2 LGR6 PMC10944252__F2 Enrichment analysis of KEGG signaling pathway, hub gene screening and PPI network analysis based on Genemania database PA2G4 EEF2 MRPL24 RPL27 RPS3A RPS24 EMG1 MRPS12 WDR36 NHP2 BMS1 RPL27A MRPS15 PMC9142523__F7 Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation NLRP3 TLR4 IL1B PMC3349963__F1 Canonical and non-canonical IL-13 signaling in cells IL13RA1 TYK2 STAT3 PMC3001886__F5 Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional Response IL13RA2 IL13 APP IL6ST IL4 RHD TGFB1 ADM IFNG STAT3 PMC11274159__F2 EBV-affected signaling pathways associated with ferroptosis ELAVL1 GPX4 CDKN1A FANCD2 SLC7A11 DPP4 ATF3 SLC3A2 POR SLC40A1 PMC7093293__F4 Role of Rho/Rho-kinase pathway in the pathogenesis of cardiovascular diseases VAMP2 BMP2 RHO PMC8394875__F4 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology MYC CD44 CCND1 BMI1 PMC1526619__F1 Wnt/Beta-catenin signaling pathway APC WNT1 GSK3B PMC1526619__F2 The canonical transforming growth factor (TGF)B/Smad signaling pathway SMAD2 SMAD4 PMC33831__F1 The branch of the flavonoid pathway for the synthesis of flavones in maize HP PMC4349862__F6 Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway RNASEL IRF3 MAVS PMC8127782__F4 Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response APAF1 BCL2 BAX PMC6359724__F1 Oxygen- and hydroxylase-dependent mechanisms regulating hypoxia-inducible factor 1 (HIF-1) activity FH USP20 HEL-117 PMC9360036__F7 Proposed model of MAP4K4 and STRN3 regulation of cell migration and proliferation in MB ANKRD1 VASP STRN3 HEL-S-31 PMC7824611__F4 Diphthamide synthesis and ADP-ribosylation DPH2 DPH5 DPH3 EEF2 DPH1 PMC6359724__F2 HIF-1-dependent reprogramming of the glucose metabolic pathway, and resultant radioresistance MYC BNIP3 MXI1 PMC7838823__F4 Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses ADORA2B PIG59 MYC YES1 HIF1A E2F3 GNAI1 NFKBIA KMT2A BCAT1 ADA YY1 MAPK1 SRPK2 JUN TF STAT3 PNP AKT3 PMC7824611__F5 Proposed model of Cholix-induced cell death pathways ROCK1 EEF2 FURIN PMC6813369__F2 Proposed role of the immunogenic cell death in pemphigus foliaceus SIRPA CD47 HEL-S-99n ELL PMC6995557__F5 Schematic diagram of the proposed mechanisms by which betulinic acid ameliorates T-2-toxin-induced oxidative stress and diminishes T-2-toxin-induced apoptosis via the JAK2/STAT3 and BAX/BCL-2/caspase-3 pathways BAX PMC6255967__F4 Canonical IRF5 signaling pathway and its negative regulation IL10 TLR8 TLR7 SIK2 TRIM21 LYN TRAF6 IRAK4 MYD88 TNF CRTC3 IRF4 PMC7345582__F3 Oncogene miRs that activate the STAT3 signaling pathway and promote the proliferation and invasion of GC cells SOCS2 SOCS4 MYC IFNAR1 STAT3 PMC7345582__F2 Onco-suppressor microRNAs in the inhibition of STAT3 and the malignant behavior of gastric cancer cells TWIST1 HAS1 STAT3 PMC7345582__F5 STAT3 signaling pathway as an oncogene factor in GC cells CD163 CD44 CCND1 EZH2 STAT3 PMC5003917__F2 Aberrations in the cyclic AMP-dependent signaling pathway in adrenocortical tumors PDE11A FH PRKAR1A MEN1 MC2R ARMC5 PMC11490128__F7 Schematic model delineating the mechanisms of SEC14L3 in ccRCC NFKB1 RPS3 PMC7345582__F4 Long non-coding RNAs and their downstream targets in the regulation of the STAT3 signaling pathway in GC cells STAT3 PMC7563732__F4 Enzymes from the purine salvage cycles identified in the L GDA GMPR APRT ASL PMC7960772__F1 Immune environment surrounding a transplanted organ APC CD80 TIGIT LAG3 ARG1 ELL PMC3134325__F1 Action of ErbB receptor EGF GRB2 TGFA PMC5575491__F5 Model of melatonin regulation of bone mass ASMT TPH1 AANAT PMC8924487__F1 Extracellular Vesicles in Systemic Lupus Erythematosus LAMP2 CD82 MSC TRAF6 SP1 TNF CP PMC6896143__F4 A diagrammatic representation of the pathways that can indirectly lead to inhibition of apoptosis in a cancer cell HGF JAK1 STAT3 PMC3418714__F3 Kinase inhibitors in CLL BTK BCR BASH LYN SYK PMC3418714__F2 Integrin signaling in CLL BTK BCR BASH LYN SYK PMC3564018__F7 Transcription factors predicted to be inhibited by battlefield-like stressors and their targets among stress-modulated genes CXCL1 AFP MHC2TA ACTA2 RELB CREB1 CD74 COL1A1 IER3 IL18 A2M SBF1 CCR7 CDH2 B2M IRF-1 HSPA4 HMGB1 HLA-DPA1 PDE3B IL1A PLK3 IRF7 PF4 HLA-DOB CD44 HLA-DRB1 CD79A HLA-B CDKN1A NFKB1 RELA PMC6527602__F2 ERM structure and function in immune cells F2 LCK F3 SRC SYK COIL CXCL12 ADAM17 PMC12097394__F2 TLR/NFKB mediated inflammatory signaling and involvement of E3 and DUBs USP4 TRAF6 IL6 SPOP MYD88 OTUD4 IL1B TIRAP MYSM1 PMC3418714__F1 B-cell receptor signaling in CLL BTK FYN BASH LYN GRB2 SYK PLCG2 PMC12097394__F4 Involvement of E3 ligases and DUBs in calcium handling UBE2C JOSD2 USP25 RYR2 CBL PMC12097394__F3 Extrinsic and intrinsic apoptosis signaling pathway and involvement of E3 and DUBs USP27X TRADD APAF1 USP24 FADD BAX PMC7097917__F1 L-serine synthesis pathway PSAT1 SHMT1 PSPH HEL-S-51e PHGDH PMC10746942__F2 The function of SAMMSON in different cancers EZH2 SP1 CTNNBIP1 ME3 PMC10746942__F1 SAMMSON via different mechanisms exerts its oncogenic roles in melanoma CARF EZH2 FOXA2 PMC5955117__F6 p53 and metabolism: from mechanism to therapeutics TIGAR IL8RB MTOR PMC12005349__F1 Signalling scheme of the TGFB‐SMAD signalling pathway SMAD2 TGFBR1 SMAD4 SMAD1 DKFZp781O1323 PMC8981989__F2 Glucose, Fatty Acid and Amino Acid Metabolism by Ubiquitination and SUMOylation for Cancer Progression TRIM11 OTUB2 SUMO2 SENP1 APC TRIM21 VHL ENO1 TRAF6 SAE1 HEL-S-87p HIF1A HEL-S-162eP UBA2 RNF20 STUB1 USP22 HEL-S-133P PMC5955117__F1 P53 regulates critical points in cell signaling and metabolism TIGAR TSC2 SCO2 HP MDM2 GLS2 PHGDH PMC6643298__F9 The conclusion of the results in this study PC SMPD1 CHPT1 PMC4355577__F2 Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? MMP3 MMP10 TNC HGF MMP2 MSC MMP9 VEGFA IL6 IL4 CXCL12 PMC10918892__F5 Schematic diagram illustrating the role of miR-223-3p on NLRP3 inflammasome signaling pathway in LPS-induced HTR8/SVneo cells NLRP3 TLR4 MYD88 GSDMD PMC9327246__F8 d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model CDK2 PGP CDK6 BAX PMC6697022__F2 Tyrosine kinases in the development of atopic dermatitis BCR SYK JAK3 JAK1 TSLP PMC5745276__F2B Non-Canonical Wnt Pathway and the Notch and Sonic Hedgehog Pathway-The two major non-canonical pathways are Wnt/calcium and Planar Cell Polarity (PCP) pathways SUFU SMO ARHA HES1 PMC5745276__F2A Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway TNIK APC GK3 PMC8110204__F2 Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus HMGB1 COX2 IL18 BCLAF1 IL9 IL2 MYD88 HIF1A MTOR SIRT1 STAT3 FOXP3 PMC8329528__F1 Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism TSC2 ULK1 TSC1 SLC38A9 PTEN IRS1 RHEB PMC4621929__F3 STRING network analysis reveals a database of known and predicted protein interactions EGF EID2 DNER GNB2 ROCK1 EGFR SMAD2 ABCB8 CALCOCO1 NUP62 MEGF6 CELSR2 MAF LCP2 MEGF8 A2M SRC FARP2 BANP USP29 KHDRBS2 ABCC2 ABCB1 ARHGAP22 ELK3 USP45 RND2 TACC3 DOCK1 UHRF1 MYO9B FICD PLCB4 MEGF9 LEF1 MCM6 EP300 GTF3C1 CEBPZ JAK1 MEGF11 SLA2 DYRK2 PMC5854419__F1 Mitogen-activated protein kinase signaling in plant pathogenic fungi CAP1 SF1 PMC4023360__F1 Role of Heat shock protein-27 (HSP27) and clusterin (CLU) in cancer cell survival BAD IGF1R IGF1 TNF CLU BAX PMC5545725__F4 Proposed model of dopamine dysregulation in the nigrostriatal pathway in schizophrenia TH MAOA DRD2 PMC3994501__F9 Signaling pathways for LTM formation upon associative olfactory conditioning of honeybees CS CA11 PMC3633862__F6 Interferon-Beta Induces Distinct Gene Expression Response Patterns in Human Monocytes versus T cells HMGB1 IFIT3 STAT2 IRF9 RHO RAC1 IFITM1 MX1 IFNG STAT1 OAS1 TLR4 VCAM1 TYK2 JAK1 SP1 IFI35 PSMB8 CDC42 PMC7532351__F4 Signalling Pathway Underlying PAK1-Blockers and Viral Infections PAK1 PTEN CCL2 ACE2 PMC11599025__F1 Innate immune responses against ASFV infection CGAS STAT2 IRF9 TRAF3 IRF3 TLR3 STAT1 NLRP3 TLR8 TLR7 TLR4 TYK2 JAK1 MAVS PMC5351205__F1 Sub-pathway enrichment analysis of differentially expressed genes (DEGs) MCEE ACSS3 SUCLG1 ACSS2 PCCB ACADM PMC5847475__F2 Mechanism of PD-1 and PDL-1 pathway in tumor environment and the complex crosstalk between cancer, tumor, T-cell, APC and macrophage and tumor stroma HGF APC RGMB PMC6838750__F2 Main processes involved in exercise-induced and neurotrophin-mediated increased viability of dopaminergic neurons TH BCL2 BAX PMC10778705__F3 cGAS-STING antitumoral and protumoral mechanisms TBK1 CGAS PARP12 IRF3 STAT3 PMC11625754__F4 Effect of AB on the NMJ formation process MUSK LRP4 APP PMC10374777__F2 Molecular mechanism of ferulic acid and its derivatives in tumor progression CDK2 CCND1 CDK4 MTOR PCNA CDK6 BAX PMC11667055__F6 Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation TLR4 NFATC1 ACOD1 PMC9181281__F10 Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NFKB Signaling COX2 TLR4 IL6 PMC7327948__F3 Diagram describing the possibility for Roflumilast to increase DCX and MAP2 expression NGF BDNF PMC6351175__F7 Hypothesized regulatory relationships between TGFB, Tgif1, miR‐18a, and NeuroD during photoreceptor differentiation SMAD2 TGIF1 PMC2869029__F1 Regulation of macrophage function in tumors: the multifaceted role of NFKB SOCS3 IRF7 CXCL10 IRF3 IFNAR2 IL6 MYD88 IFNAR1 ARG2 ARG1 IRF-1 IL1B STAT3 PMC8143176__F1 Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer CREB1 HSF1 PMC8323226__F5 Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications CD163 CD80 PMC7131993__F1 Increased matrix stiffness can affect cells in different signaling pathways in colorectal cancer (CRC) APC GSK3B LRP5 SRC LRP6 RHO PMC11484773__F2 Schematic diagram illustrating the interaction between neuroinflammation and microglial activation, as well as a separate schematic diagram depicting the TREM2 signaling pathway SYK ADAM10 TNF ADAM17 PMC5522997__F9 Representative gene networks that were significantly regulated (P < 0.05 with the Fisher's exact test) in response to cocaine in WT compared to SERT Met172 mice GNG13 PARM1 RASD1 GNB5 NEF3 LRP8 TMEM158 RIC8B SLC6A11 PFDN5 RYR2 PTPRB PTPRG DFFB LRP1B TU3A B3GNT2 VWF NEK1 KCNAB1 RGS11 PTPRT IRS4 KCNA5 SET LRRK2 RPL37 SCN8A RPL39 TTLL7 KCNA1 SCUBE1 CDC42EP3 SMG1 ADCY5 TNR ABCA1 SCN1A CNTNAP1 NEFL PMC10152446__F7 Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993 PMVK DHCR7 EBP DHCR24 MVK IPP PMC7851492__F1 Conflicting metabolic alterations in CSCs FBP1 MYC PMC5549772__F2 Salmonella enterica serovar-specific transcriptional reprogramming of infected cells QRFP SOCS2 SOCS3 EFNA1 IRAK2 CXCL3 PFKFB4 CCL7 CCL5 CCL2 SAA1 HIF1A IFITM1 OSMR ITGA2 OASL HEL-S-78p BCR JUNB HCAR2 ADM IRF-1 CXCL11 FGA NAMPT IL1A ITGB3 PLAUR ANGPTL4 FOS IRF9 CXCL10 ATF3 RGS2 TNC EDN1 DUSP10 BCL2A1 ISG20 IGFBP1 TRAF1 TNFRSF21 VTN CCL20 HELZ2 TNFAIP3 IFIH1 CCL22 IFIT1 IFIT3 IFIT2 RELB IL11 ACHE CEBPD HRH1 ISG15 GBP1 MT2A BIRC3 RHOB IL1B JUN KLF6 EGR1 MAFB PTGS2 LIF CXCL2 EDIL3 NFKBIA VLDLR CISH SDC4 GJA1 HEL-S-42 LBP EDN2 BNIP3 SOCS1 STAT3 PMC6944711__F3 Functional intersection of the GPCR-senescence system MAF TES GRK1 JUN PMC3480664__F1 Neurotrophin Regulation of Energy Balance in the Adult CNS and PNS CNTF POMC NPY CRH AgRP ARC BDNF PMC8666469__F3 Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection IL10 STAT1 EGF STAT2 STAT4 TYK2 IL6 JAK1 IL20 STAT3 PMC3118279__F2 Ingenuity Pathway Analysis of epidermal genetic information retrieval-harvested melanoma specimens identifies overexpressed genes involved in melanocyte development and pigmentation KIT GRB2 SRC BCL2 SOX10 PAX3 CRK PMC4426221__F2 Schematic summary graph shows the postsynaptic effects of mGluR2/3 agonists on the regulation of both AMPA and NMDA receptors CSK GSK3B SRC SNAP25 PMC8098721__F1 Canonical and non-canonical Wnt signaling pathways ZNRF3 RNF43 DKK3 BMP2 APC NOTUM GSK3B LRP5 LRP6 DKK1 RHO DKK2 WIF1 DKK4 CCND1 PMC6305219__F1 Cdon, Boc, and Gas1 act as positive regulators of Shh signaling during optic vesicle formation BOC CDON SHH SMO GAS1 PMC6915081__F7 The possible mechanism of sotetsuflavone inhibited progression of non-small cell lung cancer MTOR DKFZp686F0183 BAX PMC11693700__F8 Key proteins in the HIF, ferroptosis, PI3K/AKT/mTOR, and p53 signaling pathways are subjected to ubiquitination modifications by deubiquitinases and E3 ubiquitin ligases GPX4 OTUD1 RBCK1 USP46 VHL NOX4 USP37 MTOR TRIM47 FBXW7 BAP1 PMC11693700__F7 Deubiquitylase in the p53 signaling pathway signaling pathway RBCK1 MDM2 MTOR TRIM47 PMC11693700__F6 Deubiquitylase in the PI3K/AKT/mTOR signaling pathway signaling pathway SLC7A5 OTUD1 USP46 VHL PTEN LZTFL1 ZNRF1 FBXW7 PMC11693700__F5 BAP1 in the Ferroptosis signaling pathway GPX4 SLC7A11 HEL-S-64p VHL BAP1 PMC2815132__F1 Dopamine Synthesis Pathway: Dopamine’s synthesis pathway begins with the amino acid tyrosine and is regulated by the activity of tyrosine hydroyxylase TH PNMT DBH PMC11693700__F4 VHL and Beta-TrCP in the Ferroptosis signaling pathway VHL USP37 BAP1 PMC11693700__F3 BAP1 and USP37 in the HIF signaling pathway NOX4 EMP1 HILPDA PMC3829308__F1 Interferon beta signaling pathway TYK2 IFNAR2 IFNAR1 PMC3683326__F3 GenMAPP schematic of cell cycle pathway genes PI3 CDK2 CA14 CDK7 PCNA SKP2 MYT1 PMC3784533__F1 Emerging concepts in immunity to hepatitis C virus infection TBK1 SOCS3 CLDN1 IRF7 CXCL10 TRAF3 IRF3 IFNAR1 TLR3 CD81 LDLR TYK2 JAK1 MAVS SOCS1 PMC7798030__F2 p21 is regulated by multiple pathways KLF5 KLF4 USP11 SOX6 PCNA ECRG4 PMC6545597__F1 Proposed model showing the interactions of Nm23-H1 with cellular pathways RHO OBI1 CDC42 PMC6085137__F1 FOXO1 regulates activation and function of dendritic cells RICTOR CCR7 CD80 MTOR FOXO1 PMC3381238__F1 Schematic representation of APP processing and role of its products in AD pathology MED12 APP ACHE PMC4990059__F2 Canonical Wnt signalling pathway APC GSK3B PMC2783967__F6 Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin NR3A2 CYP1B1 HSD3B1 CRAT KIN NR1C1 THRSP ALOX15B INSIG1 FADS2 LPIN1 ELOVL3 FADS1 SOAT1 GAL FASN PMC10885964__F2 Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China BAMBI E2F4 NODAL SMAD2 EMP3 SMAD4 BMP4 IFNG TFR2 FST HDAC2 THBS1 SIN3A SKI IGSF1 PITX2 BMP2 THSD4 SMAD6 SKP1 HFE ARHA RBX1 HDAC1 SMAD1 TF PMC8615223__F1 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights TLR4 COX1 KEAP1 IRAK1 GSK3B TRAF6 IRAK4 MYD88 IL4 MTOR CSF2 NQO1 PMC5505220__F3 Modeled mechanism by which FSH via PKA inhibits MKP3/DUSP6 to promote the accumulation of phosphorylated ERK in preantral GCs EGFR GRB2 FSHR PMC8505973__F1 Resistance to Hypomethylating Agents in Myelodysplastic Syndrome and Acute Myeloid Leukemia From Clinical Data and Molecular Mechanism CDA VCAM1 MSC TRAF6 CD40 CD80 CDK9 NSUN3 PMC5567910__F8 A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development SHH SMO BMP4 FOXF1 PMC8615223__F6 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights TLR4 KEAP1 GSK3B PTEN MTOR PMC8615223__F5 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights BAD APAF1 CDK2 BCL2 CDK4 CDC2 FADD CDK6 BAX PMC8615223__F4 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights BAD GSK3B MDM2 BCL2 PTEN MTOR PMC8615223__F3 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights BAD EGFR PTEN HIF1A MTOR IRS1 CDK6 RHEB TSC2 COX2 TSC1 APAF1 CDK2 MDM2 GRB2 BCL2 CDK4 CDC2 FADD BAX PMC5946330__F7 Proposed role of TGFB1 signaling in HASM cell shortening and hyperresponsiveness SMAD2 SMAD4 ARHA PMC6156841__F1 Human Disease Phenome construction SNCA LRRK2 NDUFV2 PSEN2 SNCAIP HTRA2 PINK1 HEL-S-67p PSEN1 NDUFA9 APP PSENEN NDUFS8 SDHA PMC10960765__F2 Ubiquitination enzymes in the Wnt/Beta-catenin signaling pathway of CRC ZNRF3 RNF43 APC SMURF2 RNF146 TRIM27 TRIM29 UBE2S PMC11545986__F3 Circadian dysregulation of lipid metabolism and adverse pregnancy outcomes CPT1A CRY2 ACADVL LPA PER2 PER3 PMC7603577__F9 Relaxin signaling pathway in the treatment of gout and hyperuricemia with plantain MMP2 MMP9 RXFP3 TGFA PMC9540480__F1 Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need TLR8 TLR7 IRF7 PMC7603577__F7 IL-17 signaling pathway of plantain in the treatment of gout and hyperuricemia COX2 TRADD MMP9 GSK3B TRAF6 IL17RB IL17RC FADD TAB3 PMC7956553__F3 Simplified cartoon of potential crosstalk between activated canonical Wnt/Beta-catenin and mTORC1 pathways TSC1 GSK3B EIF4E MTOR PMC4197875__F2 Hippo signaling pathway in stem cell biology and cancer CDX2 AMOT NF2 HAND1 LATS1 LATS2 GATA3 PMC7956553__F2 Cartoon of major proteins in the wingless-related integration site (Wnt)/Beta-catenin growth pathway ZNRF3 RNF43 APC LRP5 LRP6 GPR49 PMC4197875__F1 Hippo signaling pathway in stem cell biology and cancer AMOT SIK2 TAOK3 MARK4 SIK3 MARK1 SCRIB LATS1 RHO MOB1A PAX3 FAT2 LATS2 FAT3 TAOK1 SIK1 FAT4 TAOK2 PATJ ZYX NF2 RASSF6 FRMD6 PMC6406015__F1 Regulation of B cell receptor (BCR) signaling on B cell survival BAD CAP1 GSK3B CD79B CD79A CAP2 BTK CARD11 BCL10 RASGRP3 BCR BCL2 SYK MCL1 CD19 PMC7956553__F1 Cartoon of major proteins in the mechanistic target of rapamycin (mTOR) growth pathway TSC2 TSC1 EIF4E RHEB PMC5539260__F7 Overview of the pathogenic model of C. difficile infection CD46 EGFR SYK REL NOX5 SCARA3 PMC4197875__F4 Hippo signaling pathway in stem cell biology and cancer TG PMC11788642__F8 Schema of Rnf111 regulating the development of hematopoietic stem and progenitor cells by maintaining Smad2/3 phosphorylation and activating the Gcsfr/NO signaling pathway SMAD2 SMAD4 CEBPB PMC4197875__F3 Hippo signaling pathway in stem cell biology and cancer NF2 LATS1 LATS2 PMC11356930__F5 MEHTCMPs on intestinal flora TLR4 MYD88 TNF PMC11356930__F4 MEHTCMPs on the NLRP3 signaling pathway NLRP3 TLR4 MYD88 PMC11356930__F3 MEHTCMPs on the MAPK signaling pathway STAT1 IRAK1 GRB2 LBP TRAF6 IRAK4 RAF1 MYD88 STAT3 PMC7956553__F4 Cartoon of mTORC1, Wnt/Beta-catenin, and estrogen receptor A (ERA) molecular pathway interplay in the female-specific, Tsc2-null, rare lung disease lymphangioleiomyomatosis (LAM) WNT3A GSK3B LRP5 LRP6 CCND2 PMC11356930__F2 MEHTCMPs on the signaling pathway of TLRs CD14 PSG1 TLR4 IRAK1 TRAF6 MYD88 PMC8064164__F1 Role of cannabidiol in Parkinson’s disease by targeting the WNT/Beta-catenin pathway, oxidative stress and inflammation APC GSK3B LRP5 LRP6 PMC6746018__F1 PI3K/Ras signaling pathway NF1 BRAF GRB2 SOS1 MTOR CBL PMC9139230__F1 How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives F2 EGFR ARHA ACLY SOS1 MTOR HEL-S-133P HK2 PMC5539260__F5 Host/pathogen cross-talk mechanism through core pathways at the early stage of C LRRK2 TSPAN7 ARHA PTEN RAC1 DKFZp686L0365 HEL-S-125m PAK1 COPS5 GRB2 STK11 SYK YY1 RPS3 SCARA3 PMC8358930__F1 Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma LATS1 LATS2 PMC9258583__F8 Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress INO80 CDS1 RAD51 CRB2 PMC8874408__F6 3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFRY1086 Phosphorylation EGF STAT2 ATM EGFR GSK3B SRC MTOR STAT5B STAT3 PMC9713001__F2 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma SLC7A5 GOT2 HEL-S-133P GFPT1 HK2 GLS PMC10759355__F1 Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability TLR4 AGA MYD88 PMC5982750__F5 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand CYP3A4 ABCB1 PMC9713001__F4 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma ULK1 GPX4 ATG3 SLC7A11 SMAD4 SLC3A2 MTOR STAT3 PMC5982750__F4 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand CES2 CES1 APC ABCB1 PMC9713001__F6 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma SOCS3 UCP1 SMAD2 TGFBR2 VHL SMAD4 PTEN SOCS6 FOXO1 CEBPB STAT1 ZEB2 TFAP2C HOXA1 JUNB BNIP3 SOCS1 STAT3 PMC5982750__F1 Fluoropyrimidines pathway DPYD TYMS PMC9072012__F3 CTNNB1 in Endometrial Cancer APC GSK3B PMC3145575__F3 CSR pathways for primary non-HCC hepatocytes and HCC (Huh7) cell types NLK INA DAP MTOR TGFA IFNG PMC5982750__F3 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand ERCC1 HEL-S-22 PMC6019481__F10 Estrogen signaling pathway PIK3R1 EGFR CREB1 GNAI1 MMP2 ATF4 SRC MAPK1 SP1 FKBP4 JUN GPER OPRM1 FOS HBEGF HRAS KCNJ3 PLCB1 CALM1 MAPK13 GABBR1 MAP2K1 GRB2 PIK3CA GNAO1 GNAS RAF1 SOS1 CALML3 SHC1 PMC6122186__F1 Hippo signaling pathway LATS1 LATS2 PMC6122186__F2 Simplified illustration of YAP/TAZ and glycolysis OGT FOXC2 HK2 PMC2729314__F2 Wnt signaling network STOM APC LRP6 RHO PMC5621106__F1 Double-strand break (DSB) repair pathway choice BLM WRN DNA2 PMC3671630__F1 Nucleotide excision repair POLE POLK XPC ERCC1 XPA DDB2 DDB1 PCNA UVSSA PMC7986633__F4 Proposed model of how deflavination of ACAD9 by ECSIT permits the coordinated regulation of the FAO and OXPHOS pathways NDUFAF1 ACAD9 ECSIT PMC3109492__F2 Intestinal Effector T Cells in Health and Disease IL25 TSLP FOXP3 PMC8129117__F6 Proposed model of ROS generation and regulation of survival signals in CLL cells BTK BCR LYN MTOR AXL PMC7402427__F8 Summary for nuclear and cytoplasmic roles for EZH2 during osteoclastogenesis MAFB EZH2 MTOR PMC1828067__F7 Osteopontin/AvB3 signaling in the regulation of prostate cancer cell migration CD44 SRC RHO PMC11824814__F8 Dietary DHA Regulated the Androgen Production in Male Chinese Tongue Sole Cynoglossus semilaevis HSD11B2 HSD3B1 HSD17B1 HSD17B2 HSD17B3 STAR PMC11491976__F3 PI3K/AKT/mTOR signaling pathway EGF IGF1R EGFR IRS1 RHEB PMC11491976__F2 PI3K and PIP2-mediated pathway PCK1 MTOR PMC4766410__F5 Extracellular calcium-sensing receptor regulates human fetal lung development via CFTR CLCN2 CASR CLCA1 CFTR PMC8770601__F2 Effect of oxidized lipids of function of myeloid cells in cancer MPO CD36 PMC8770601__F1 Major metabolic pathways leading to the formation of signaling molecules from PUFA-GPL and pGPL COX2 MPO MEN1 PMC7941238__F2 Mechanisms by which ADSCs‐EXOs may promote wound healing MMP3 RBP4 CDH2 PCNA PMC4552732__F4 A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung ASAH2 NSMAF SPTLC3 PAH SGMS2 PMC6749995__F4 Lung microenvironment: an important regulator of tumour growth and metastasis PIGF CCR2 CXCL5 MMP9 IL8RB ALOX5 CCL5 CCL4 CCL2 S100A9 TNF CR1 TLR4 S100A8 IL1B CCL3 PMC5571607__F2 DAMP/ TLR/ inflammasome interactions NLRP3 HMGB1 TLR4 IRF7 IRAK1 IRAK2 CD44 TRAF6 IRF3 MYD88 TIRAP PMC6503994__F8 Potential role for TXNIP in HG-mediated RPE dysfunction NLRP3 TXNIP RPE PMC5395201__F3 Inactivation of Retinoblastoma Protein in Uveal Melanoma by Phosphorylation of Sites in the COOH-Terminal Region CDK2 CDK4 CDK6 PMC5824774__F5 Result of ‘Networks’ query way CUL5 EREG EGF EGFR NRAS MYC LRPPRC UBB IL6R ADAM17 ERBB4 SEMA4D RPS27A REST RHOB ERBB3 NRG2 CDC37 RNF4 RAC1 IL6 HRAS ARHG MAP2K1 MAX TFF2 STUB1 TFF1 GRB2 ERBIN RND1 TGFA NRG4 SHC1 LAT PMC7527574__F1 Therapeutic targeting of HGF/c-Met pathway BAD HGF SRC MTOR AXL PMC8144308__F1 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics RORA PMC8012701__F2 Lipid metabolisms change in dormant cancer cells LBR SCD MYLIP SREBF2 ACSS2 TM7SF2 ACSM3 MSMO1 HMGCR PMC4576413__F3 Redox control of protein degradation KEAP1 VHL RBX1 IL1B PMC3983080__F1 Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics PLCG1 ITK LCK ZAP70 GRB2 LAT PMC6108937__F3 Androgen receptor signaling R promotes diverse metabolic processes ACACA ACLY FASN PMC2576041__F9 The role of the IGF-1/phosphatidylinositol 3-kinase (PI3K)/Akt pathway and atrogin-1 and MuRF-1 in SI-induced atrophy and in the amelioration of atrophy by high-load isometric contractions SI MTOR IRS1 PMC1574111__F3 Proposed mechanism for FK506-potentiated neurite outgrowth NGF GRB2 CDC42 PMC8144308__F2 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics RCAN1 PMC6788940__F2 Targetable pathways in ESR1 mutant cells identified in preclinical studies IGF1R IGF1 CDK2 MTOR CDK7 PMC9406846__F2 Clinical and Molecular Implications of Osteopontin in Heart Failure OGDHL CD44 TF PMC5940273__F3 Repressing the repressor: Ezh2 mediates macrophage activation SOCS3 TRAF6 MYD88 PMC6500576__F2 Melanocortin pathway and control of appetite- progress and therapeutic implications ROCK1 TRPC5 OCA2 FOXO1 STAT3 PMC6675248__F1 Various molecular inhibitors and stimulators in mTOR signalling pathway NF1 TTI1 TFEB RHO PTEN EIF4E DEPTOR EIF4B SGK1 RHEB PMC6675248__F3 Role of mTOR signalling pathway during protein translation ELF3 EIF4E MTOR PMC6675248__F2 Cell signalling dysfunction in mTOR signalling pathway leading to syndromic and idiopathic autism NF1 TSC2 TSC1 PTEN EIF4EBP1 RHEB PMC9390702__F1 Targeting KRAS: Crossroads of Signaling and Immune Inhibition EGFR CDK4 SOS1 MTOR CDK6 PMC7541823__F5 Pathway of phagosome biogenesis, maturation, and phagolysosome fusion for efficient clearance of Mtb ESX1 MTMR3 M6PR CD63 EEA1 RILP RAC1 ARF6 PTPA SNAP23 PMC7541823__F1 Receptors implicated in the internalisation of Mycobacterium sp NLRP3 CD14 TLR9 MARCO APC CR1 AIM2 NOD2 TLR3 IFI16 ELL CD36 PMC10963452__F4 Schematic plots illustrate the signaling mechanism of other organokines in intervertebral disc cells MAF GHSR TFEB ANGPTL4 KEAP1 GSK3B FSTL1 ANGPTL8 MTOR PMC4788929__F6 MELK and stathmin signaling GRB2 SHE PMC10963452__F3 Schematic plots illustrate the signaling mechanism of various osteokines in intervertebral disc cells SPARC CXCR1 SHH IL8RB PMC6054915__F6 Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells MOG MBP APC TEF PMC10963452__F2 Schematic plots illustrate the signaling mechanism of various adipokines in intervertebral disc cells ADIPOR1 CMKLR1 ADIPOR2 C6 ARHA LEPR MYD88 SIRT1 STAT3 APPL1 PMC8305053__F1 Mutations in TSC Genes on Neurodevelopment and Synaptic Transmission TSC2 RICTOR TSC1 PTEN TNF MTOR IRS1 RHEB PMC5400646__F8 Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway HEL-S-99n PRDX5 EIF4E HEL-S-130P S100A6 PMC4260148__F3 Details of genes in the ‘acute phase response’ biological pathway identified in Ingenuity Pathway Analysis, which are differentially expressed in the frontal section of SHRSP vs. WKY rats at 5 weeks of age FGA HP F2 CRP MTOR PMC7541823__F7 Antigen presentation, T‐cell responses and activation of the cytosolic surveillance pathway (CSP) in the case of Mycobacterial infection of APCs CGAS CD1A IRF3 B2M CD1C PMC8539333__F1 Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence GPX1 PTEN CYP1A2 CCNE1 NLRP3 AHR CYP3A4 CDK2 CCND1 CDK4 CYP1A1 STAT3 BAX PMC9039735__F3 Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns NAPRT NAMPT NMNAT1 NMNAT2 PARP2 PARP1 NMNAT3 PARP4 NRK PMC8708448__F4 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective KIF7 SUFU GLI3 SMO PMC3844392__F1 Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses TIGAR TSC2 APAF1 MDM2 ATF3 PTEN BNIP3 BAX PMC8708448__F3 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective YAP1 PTCH1 CCND1 BMI1 LATS1 LATS2 CCNE1 PMC7676498__F2 The Microenvironment in Controlling the Fate of Bioprinted Stem Cells EGF HGF SMAD2 SMAD4 MTOR PMC8708448__F2 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective MAML1 CDKN1A ERBB2 MYC NRARP CCND3 PMC8708448__F1 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective MMP7 TNIK LRP5 CD44 CCND1 LRP6 HNF1A DKK1 PPARG BCL9 WLS PMC12171307__F3 Common regular pathways of ncRNAs MYB TNIK CRABP2 SMAD2 SMAD4 LRP6 ALX4 PORCN PTEN MTOR SLPI HAS2 HEY2 CDK2 E2F2 CCL18 CXCL12 CDH2 SMAD1 PSMB8 PARD3 DKFZp781O1323 STAT3 AKT3 PMC11910855__F8 Schematic diagram illustrates the impact of targeted activation of ErbB4 receptor on hippocampal neuronal damage, neuroinflammation, and cognitive functions in mice exposed to PS-MPs NLRP3 ERBB4 TLR4 DOCK3 SYT1 SYP SIRT3 PMC12171307__F1 EMT and Tumors EGFR VEGFA SRC PRRX1 BRCA1 AKT3 STAT3 PMC3335376__F8 Therapeutic modulation of the TP53 pathway PML MEI1 TDG BLM JMY PTEN IL6 WRN SOX4 MTBP ATM MDM2 ATR FADD STAT3 PMC4227160__F4 Proposed model of the roles of CDKN1A and KIF20A in cell cycle control via RB/E2F pathway CDKN1A ATM CDK2 KIF20A CENPE CDK4 ATR CDK6 PMC3335376__F4 Illustration of p53 TIAs in lymphocytes CASP3 ME1 BAD MEI1 CASP9 MTOR BAX PMC4747358__F3 Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine PROP1 GPR137B GALR3 MYC SPRR3 MTNR1A UNK AVPR1B RXFP2 PMC9406846__F4 Clinical and Molecular Implications of Osteopontin in Heart Failure MTOR ATR PMC8923702__F7 Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGFB/SMAD Signaling Against Candida albicans Infection SOCS3 SMAD2 SMAD4 JAK3 STAT3 PMC3737294__F1 Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance ME1 GOT2 CIT GLUD1 MAL PMC2714846__F6 Estradiol-17B, prostaglandin E2 (PGE2) and the prostaglandin E2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium PTGER2 PTGS2 PMC11695279__F4 M6A-mediated tumor regulation in the immune microenvironment IL8RB ALKBH5 IGF2BP2 SLC16A3 YTHDF1 METTL14 TLR4 METTL3 IGF2BP3 CD40 CD80 JUNB STAT3 PMC12179417__F6 Endoplasmic reticulum stress promotes the immunosuppressive activity of M2 macrophages and myeloid‐derived suppressor cells to enhance tumor immune escape SIRPA CD47 ATF4 NOS2 ARG1 XBP1 STAT3 PMC12179417__F5 Endoplasmic reticulum stress affects the function of dendritic cells and T cells, leading to immune evasion ATF4 ERO1A XBP1 PMC5989534__F10 Schematic summary showing how VPS35 might regulate LRRK2 and LRRK2 protein kinase activity and hence PD VPS35 LRRK2 VPS29 PMC9004553__F8 Construction and evaluation of a nomogram for predicting survival in patients with lung cancer CKS2 MYBL2 BIRC5 CDKN3 UBE2T TOP2A DBF4 TK1 SPAG5 UBE2S CDC20 HMMR CDC6 RRM2 BUB1B CDCA3 EZH2 PTTG1 TRIP13 SKP2 SPC25 PMC12179417__F4 Endoplasmic reticulum stress on antigen–MHC‐I complex and natural killer cells ATF4 MICA XBP1 PMC3656827__F2 Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review JAK3 JAK1 PMC4978167__F1 Integration of Endothelial Protease-activated Receptor-1 Inflammatory Signaling by Ubiquitin TH ARHA RHO PMC9611148__F3 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway TBK1 CGAS IRF3 PMC3514733__F1 Chemotactic signaling pathway in sperm HEL-S-11 GC PMC9611148__F2 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway CGAS EIF2A IRF3 PMC6679869__F1 The role of inflammasomes in lupus nephritis TLR8 TLR4 AIM2 IFI16 PMC2721475__F1 Downstream targets of IGF-1R TSC2 TSC1 GRB2 MTOR IRS1 PMC8622815__F1 AHR Ligands in Skin Homeostasis and Cutaneous Inflammation AIP AHRR AHR SRC PAH TF PMC7585866__F2 Pathogenesis of renin-angiotensin system in acute lung injury caused by viral infections ACE2 TMPRSS2 PMC7585866__F1 Diagram of regulatory mechanism of renin-angiotensin system (RAS) ACE2 PMC10949864__F3 Mechanisms for the extracellular acidification inducing alterations of Ca2+ fluxes TRPC4 TRPC1 TRPC5 CNP GPR4 TRPV1 PMC9384336__F5 Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method TBK1 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 PMC9437842__F4 GRPR neural and signalling pathways NPY1R NPY GRPR ITCH PMC10949864__F2 Cancer-associated alterations of Ca2+ fluxes at acidic tumor microenvironment and targets ROCK1 ARHA TRPV1 TRPC4 TRPC1 PGP EIF2A TRPC5 RAF1 ABCB1 SGK1 STAT3 CPZ PMC4403492__F1 HPV carcinogenesis UBE3A MDM2 CDK4 RB1 KDM6B TERT PMC5532627__F2 Linking processing of clustered DNA damage and immune response FEN1 ATM HEL-S-92n CCL2 PMC4005972__F4 Proteins involved in the BCR signaling pathways BAD CSK ARHA PLCG2 RAC1 MTOR PAG1 CDK6 FYN BCL10 BIK LYN CDK4 PMC10378342__F2 Intravenous Immunoglobulin in Kawasaki Disease—Evolution and Pathogenic Mechanisms NLRP3 IL18 TRAF5 IL1B PMC3735686__F1 Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma POLE ERCC1 RCC1 XPA PCNA PMC8907745__F2 Molecular Brakes of Adipose Tissue Lipolysis PDE3B EGR1 IRS1 PNPLA2 PMC8907745__F1 Molecular Brakes of Adipose Tissue Lipolysis G0S2 PLIN1 TG PPARG HILPDA PMC7290982__F1 GD T cells activation MICB APC MICA IPP PMC7968373__F1 Swimming towards solutions: using fish and frogs as models for understanding RASopathies NF1 GRB2 SPRED1 SHOC2 CBL PMC199174__F9 Models for the function of Ser307 phosphorylation IGF1 GRB2 IL1B PMC2533145__F10 Rap1 and glycolytic/TCA cycle reaction HEL-S-49 ENO1 ENO2 HEL-S-4 PMC4592441__F4 Myc-regulated metabolic pathways in cancer MYC ACLY HEL-S-133P GLS PMC10158029__F12 The regulator mechanism of S100A16 in Glioma S100A16 LATS1 CUL4A PMC11699442__F4 Dietary acrylamide on kidney and liver health: Molecular mechanisms and pharmacological implications IL6 MTOR BAX PMC11763285__F5 Regulatory pathways controlling cell proliferation and differentiation RIT1 PAK1 NF2 COQ6 INF2 MTOR CDC42 PMC8324353__F6 Antitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular Carcinoma by Targeting the DNA Damage Pathway ATM BRCA2 SSB CDC25B ATR BRCA1 PMC6201924__F4 Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress AIDA RPE PMC4190558__F1 Repair of oxidative DNA lesions by the MMR pathway MLH3 MSH6 LIG1 MSH2 MUTYH RAD18 PCNA PMS2 PMC4629217__F2 Roles of FXR in regulating lipid and glucose metabolism HEL-S-62p APOB LPL NR1C1 PMC156758__F1 NEW EMBO MEMBER’S REVIEW IL2 IL4 TRAF2 PMC6909742__F2 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology DUOX1 DUOX2 NOX4 PMC7696043__F1 Nuclear factor-kappa light chain enhancer of activated B cells (NFKB) pathways LTA RELA LTB RELB PMC5084660__F3 Putative molecular pathway that links GSK3B activity with the resistance of pancreatic cancer cells to DNA damage induced by gemcitabine and ionizing radiation GSK3B CDK4 CDK6 PMC6909742__F5 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology HDAC2 HDAC1 TF PMC5380843__F8 Proposed model for activation of IFN by doxorubicin bypassing IFN antagonism by Ebola virus VP35 protein TBK1 CGAS IRF7 ATM IRF3 TOP2A MAVS PMC5078034__F8 Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy CDK2 MDM2 CCND1 BCL2 CDK4 ATR CDK6 BAX PMC9631451__F8 Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer IKBKG BRAF MAPK8 PTGS2 MAPK10 GSK3B VEGFA IL6 TNF PRKCA IKBKB CASP3 MAP2K1 PRKCB EP300 CASP9 CCND1 MAPK1 GNAL MAPK11 JUN PMC6696055__F2 Regulation of autophagy by ROS ULK1 ATM PTEN ATG14 DKFZp686F0183 PMC7459008__F1 PI3K-Akt pathway mediated antiviral mechanism in silkworm Antheraea mylitta PDK2 GRB2 SHB MTOR IRS1 SGK1 PMC7843495__F3 Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer TH LIPE PMC7493965__F10 Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-tomesenchymal transition MMP2 RECK TIMP3 TRAF3IP2 IL1B PMC6443597__F8 miR-4739/BMP-7/Smad1/5/9 pathway induces pleural fibrosis SMAD2 SMAD4 BMP7 COL1A1 SMAD1 DKFZp781O1323 SMAD9 PMC8121554__F6 Isoquercitrin protects HUVECs against high glucose-induced apoptosis through regulating p53 proteasomal degradation BCL2 BAX PMC4292169__F1 The meiotic recombination pathway SPO11 MRE11A PMC6218458__F1 Canonical Wnt pathway and the role of the LRP6 receptor APC LRP6 DKK1 PMC5845557__F2 Invariant NKT (iNKT) cell activity within the tumor microenvironment (TME) CD1D APC IFNG PMC1955758__F2 How both apoptotic death and immunity may be triggered by dsRNA RNASEL RNASE1 BAD FADD BAX PMC11828848__F4 Enzymes of energy metabolic pathways divergent in UGT2B17-deficient livers PC H6PD GCK HEL107 UGGT1 PMC3555518__F1 Mechanism of miRNA expression and/or function perturbation DGCR8 DROSHA DDX5 FUS PMC3079374__F1 Simplified schematics of the MAPK and PI3K pathways in melanoma and the clinical compounds available for their inhibition RICTOR BRAF PTEN MTOR ARAF PMC6957369__F3 Core analysis of genes differentially regulated by SP-D nitrosylation MMP10 IL1A PTGS2 GADD45A CXCL2 MYD88 TNF MMP7 TNFSF6 VCAM1 CCL20 CD40LG IL2RA SELP NOS2 IRF-1 IL1B SELE PMC6781692__F1 Shh signaling pathway in hepatocellular carcinoma SNAI1 SUFU GLI3 SHH BCL2 SMO CHSY1 PMC6989408__F5 Mitochondria-associated ER membranes in normal versus cancer cells MFN1 PACS2 VAPB MFN2 TMX1 PMC3298638__F2 Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs MAML1 LRP5 LRP6 SMO BCL9 PMC6627123__F5 Involvement of FGFR4-related signaling pathways FRS2 GRB2 SRC SHB PTEN MTOR CRK CYP7A1 PMC12217889__F4 Crosstalk Between the C1 Subpopulation and EndoCs, ECs, and Macrophages PTN ACKR3 CXCL12 MDK PMC3989895__F2 Simplified pathway map of CCN1 and CCN2-dependent outside-in signaling pathways regulating endothelial cell function and behavior ASB1 EGFR LRP5 LRP6 CTGF BMP4 LRP3 CYR61 CCNI LRP4 SRC RAF1 CDC42 PMC4850435__F6 Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions TLR9 CCL5 LY96 MYD88 TLR8 TLR7 TLR4 CASP8 IL1B CXCL11 CD14 TLR5 CXCL10 CCL4 RAC1 IL6 TLR1 TLR3 LBP CXCL9 CD40 CD80 FADD TIRAP CCL3 PMC6117946__F3 Non-enzymatic Krebs cycle-like reactions that occur in the presence of peroxydisulfate and FeS form a network that closely mimics the typical (oxidative) Krebs cycle and the glyoxylate shunt FES CIT MAL PMC8438071__F8 In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy REN PARP1 BAX PMC6006503__F1 Role and molecular pathway of IL-32 in cancer IL1B STAT3 PMC12172856__F7 Interaction network of key signaling pathway-mRNA-miRNA FST MAP3K1 SNAI1 ACVR2B RPS6KA1 GDF15 RASGRF2 ZEB2 IRS1 CDC42 BMP4 PMC7169114__F2 Long noncoding RNAs (lncRNAs) regulate innate immune responses through activation of RIG‐I and via deregulation of epigenetic mechanisms TLR4 RELA CCL5 PMC8004488__F8 Astrocytes morpho-functional alterations in ADLD phenotype CTRL LIF STAT3 PMC6349383__F3 Summary of the oncogenic pathways genetically disrupted in the UM-SCC oral cavity cell line panel IGF1R KEAP1 EGFR TP63 NFE2L2 MYC FGFR3 PTEN RB1 CDKN2A FAT1 CDK6 FGFR1 ERBB2 NOTCH1 CCND1 CASP8 LTBR PMC8125319__F2 Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma BRAF PTEN MTOR PMC64750__F4 Metabolic pathways related to cell-wall formation CAD PMC4033425__F3 Cell-cell coupling in the somitogenesis clock SI LFNG IFNG PMC2718282__F8 The role of Mal connecting PI3K to TLR2/6 MYD88 TLR1 MAL PMC3069496__F1 miRNA biogenesis pathway AGO1 AGO2 DGCR8 AGO4 DROSHA CCR4 PMC6619735__F9 Proposed model illustrating the mechanism of arctigenin-mediated AB production inhibition and AB clearance promotion BACE1 ULK1 EIF2A APP MTOR PMC3395995__F1 Alloantigen presentation via the direct, semi-direct and indirect pathways following organ transplantation, and (B) the relative intensity of each antigen-presentation pathway during the post-transplantation (post-Tx) period APC REL PMC9586542__F6 Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease PC TG PMC3067333__F5 Schematic presentation of Nag PTS and parts of the central metabolism of R PTS PDHA1 TNLG7C HPR PMC5682418__F5 Selected miRNA-mRNA interaction networks involved in Jak-STAT signaling pathway PIM1 AIP IRF9 CNTFR BCL2 MCL1 CSF2RB MTOR STAT3 PMC7093977__F3 Phenotypic response of microglia on dietary fatty acid exposure TLR4 LRRK2 TBR1 MYD88 PMC5682418__F4 Selected miRNA-mRNA interaction networks involved in T cell receptor signaling pathway PAK4 CTLA4 CBL IFNG ITK FYN BCL10 LCK ZAP70 GRB2 CDK4 LAT ICOS PMC7962119__F3 Cellular senescence (i.e., permanent cessation of cell division) is triggered by a variety of stresses FOXO4 CDK2 BCL2 CDK4 CDK6 PMC7037145__F3 Conflicting role of JNKs in dermal fibroblast biology COL1A2 COL1A1 TNLG7C PMC7697568__F1 Wnt signaling pathway RNF43 APC NOTUM GPR49 PMC7388440__F6 RA pathway model GSK3B ROR1 PMC5702396__F1 Apoptotic Pathways in Glioblastoma MDM2 PTEN BAX PMC8450475__F1 Manifestations and Management of Hepatic Dysfunction in Congenital Disorders of Glycosylation ALG9 VMA12 ALG3 ALG12 TMEM165 ALG5 ATP6AP2 VMA22 SLC30A10 PMC10933834__F9 Biosynthesis pathway and gene cluster of erythromycin PCCA ACP2 ACP3 PMC8012461__F2 Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation EGR1 BTRC AMOT AREG GSK3B MYC LATS1 CTNNA1 RHO LATS2 ERBB4 NF2 TP73 TBX5 hCG_2014051 HEL113 PMC7697568__F3 Target therapies for ligand-dependent tumors RNF43 APC LRP5 LRP6 GPR49 PMC1584297__F9 Cross-talk between the NFKB and the STAT3 pathways IL6 IL6R STAT3 PMC10917541__F3 NMN-mediated longevity and the main reasons for decreasing NAD+ level with age TNKS SIRT1 PMC5833861__F2 Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies APC CD80 PMC5468379__F1 Viral RNA detection by RLRs and TLRs, signaling pathways and overview of FMDV strategies aimed at its supression TBK1 STAT1 TLR8 TLR7 TANK STAT2 IRF3 TYK2 IFNAR2 IFNAR1 TLR3 MAVS PMC9697406__F1 Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer PIK3IP1 ANXA1 SLC7A11 HDAC2 YES1 EZH2 STAG1 MSH2 MTOR ATR ARID1A TERT PMC4428707__F11 SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation CD14 TLR4 RAC1 PMC7802216__F5 Roles of palmitoylation during structural LTP LIMK1 PICK1 ARHA RAC1 CDH2 CDC42 PMC8273837__F4 Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis FOSL1 LRP5 CCND1 LRP6 ARHA ROR2 SENP2 CCND2 PMC3055758__F8 Mechanism of cAMP inhibition of MAPK activity EGF SRC VIP PMC5672329__F3 Outside-in signaling through class I PI3Ks BTK TEC SRC SYK RASA3 PMC8636777__F4 Weighted Gene Co-Expression Network Analysis and Treatment Strategies of Tumor Recurrence-Associated Hub Genes in Lung Adenocarcinoma VASP POPDC1 DLG2 SYNPO RAG1 RHO GATA4 CFTR PALS1 REL CDC42 RAB13 MKX PMC9412801__F2 Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy? CD14 TLR4 TRAF6 MYD88 TLR1 PMC6274719__F1 Three apoptotic pathways (Extrinsic, intrinsic and granzyme pathways) SET GZMA FADD PMC7175142__F4 Influence of lipid mediators on ER stress-dependent pathway.Disorders in synthesis or action of exogenous factors, like lipid mediators (black) may lead to the generation and accumulation of abnormal proteins (AP) BCL2 XBP1 PMC6415584__F1 Pyruvate and glutamate are 2 major metabolic hubs in GSCs PC HK2 GLS PMC3895844__F3 Dopamine-DARPP32 feedback in cAMP signalling is a significant canonical pathway in an olanzapine-treated hippocampus CREM OTP PMC7175142__F3 Influence of lipid mediators on the mitochondrial pathway COX2 HEL-S-28 PMC3895844__F2 Ephrin receptor signalling is the most significant canonical pathway in an olanzapine-treated cerebellum EGF FYN KALRN HEL-S-11 ARHA CRK PXN STAT3 PMC7753989__F6 Schematic model depicting the role of ADAM17/HB‐EGF/EGFR signalling pathway in directional collective migration of epidermal cells EGFR HBEGF ADAM17 PMC7175142__F1 Main apoptotic pathways TRADD BCL2 XBP1 FADD PMC4483595__F4 Proposed mechanism to explain the protective effect of CFHR1,3 deletion on the development of IgAN HEL-S-62p CFHR3 CFHR1 PMC4483595__F1 Three pathways of complement activation HEL-S-62p CD59 C9 MASP1 FH C7 C6 C4A CR1 PMC9033378__F7 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques PC COCH CP HYI PMC9033378__F6 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques STEAP3 FACL4 SLC3A2 TF CP PMC8799876__F2 Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis KDR PLG TF PMC6247912__F2 Somatic mutations of the canonical signal transduction and tumor suppressor pathways in HCC FANCD2 SETMAR CHD4 EIF4H PHF2 CHD5 SETD1B NF1 POLE ERCC5 MSH3 MSH2 CHDH TLK1 XPC BRD7 EIF4E HRAS BRCA1 ARID1A RHEB SMARCAD1 TET2 TSC2 KMT2C RET TSC1 KMT2A TSHR SMARCD2 CHD8 EZH1 BRD2 MLL2 PML BRAF EGFR PTEN EIF1AX MTOR TET1 JMJD1C CHEK2 ATM KAT8 SIRT6 SMYD4 KDM5C EIF4B XRCC3 SRCAP CHD2 CHEK1 PMS2 INO80 CREBBP ERBB2 KDM4C SETD2 FANCB CHD9 PMC12027943__F5 Compound–target–pathway interaction network PDE4D IGF1R F10 PRKCE PLK1 CSNK2A1 EGFR ALB GSK3B MTOR POR ADAM17 CCR1 CHEK2 PRKCA TTPA FGFR1 STS PTPN11 MDM2 SRC CCND1 PRKCI PLG NR3C2 PARP1 CHEK1 HEL-S-130P AURKA HMGCR HEL-S-22 MMP12 DHFR TYMS HEL-75 HEL-S-72p ALDH2 PMC7680500__F6 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine HEL-S-62p EGFR STK11 ABCB10 PTEN CP PMC8066409__F2 Non-transcriptional activation of IRF3 by RIPA causes cell death TBK1 CGAS TRAF3 TRAF6 IRF3 TRAF2 MAVS BAX PMC3475405__F3 Blood–brain barrier (BBB) transport in homeostasis of brain AB IL6 IL1B APOE PMC2949529__F2 O-GlcNAc Signaling: A Metabolic Link Between Diabetes and Cancer? OGT GSK3B IRS1 PMC8066409__F1 Transcriptional and non-transcriptional activation of IRF3 by virus-activated signaling pathways lead to host antiviral response TBK1 CGAS EGFR EIF2A TRAF3 SRC IRF3 TRAF2 TLR3 MAVS BAX PMC7426728__F2 DNA methylation regulates the PI3K/PTEN/AKT/mTOR signaling pathway in the resistance to therapy in cancer BAD SALL2 PTEN MTOR DEPTOR DNMT3B TGFBI PMC7426728__F1 Activation of the Wnt/Beta-catenin signaling pathway in the resistance to therapy in cancer by methylation DKK3 APC GSK3B LRP5 LRP6 SFRP1 WIF1 PMC7680500__F3 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine CS FH OGDHL IDH3B SUCLG2 PCK2 HEL60 MDH2 PMC9675292__F1 Insulin Receptor Substrate Signaling Controls Cardiac Energy Metabolism and Heart Failure PC F2 GCK PDK4 FASN PMC7680500__F2 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine HEL-S-30 ENO1 ADH5 PFKP HEL-S-133P HEL-S-281 HEL-S-162eP PMC5904231__F2 Process diagram indicating the p16INK4a/p14ARF–RB–p53 pathway in normal conditions ATM ATR CHD5 PMC6626430__F6 Proposed model illustrating the anti-IL-1B activity of matrine NLRP3 TLR4 DHX36 DDX19A MYD88 IL1B PMC9466978__F1 Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair PINK1 LRRK2 SSB BRCA1 PMC5216946__F13 Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer RHO SP1 IPP HMGCR PMC3612034__F3 Identifying Resistance Mechanisms against Five Tyrosine Kinase Inhibitors Targeting the ERBB/RAS Pathway in 45 Cancer Cell Lines CD9 EPCAM LGALS8 PMC6627955__F4 Sphingolipids (SLs) together with the responsible key genes involved in regulating the pathway FADS2 SCD PCK1 UGCG PKLR FADS1 GCK CERK FASN PMC9218363__AF1 Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A EIF4E MTOR FADD PMC10374032__F1 Genome-scale metabolic modeling and in silico analysis of opportunistic skin pathogen Cutibacterium acnes ME1 PIG59 COA4 CS HMBS DSC1 CIT MME RPE HACD1 MAL PMC4612707__F5 Quantitative analysis of transcriptional levels of genes in the xylose metabolic pathway and the central carbon metabolism pathway HEL-S-49 HEL-S-26 PCK1 FBP1 ENO1 ENO2 tal-1 HEL60 HEL-S-32 MAL HEL-S-68p PMC7082774__F1 Emerging roles for branched chain amino acid metabolism in cancer PPM1K ACLY MTOR PMC8137995__F4 Modeling the Th17 and Tregs Paradigm: Implications for Cancer Immunotherapy ITK FAU MTOR IL23R FOXP3 PMC8160296__F5 Circular RNAs in Hepatocellular Carcinoma: Emerging Functions to Clinical Significances BAD PTEN BAX PMC9343399__F7 Key role of aminoacylase-1 in myocardial fibrosis and the regulatory effect of 20(S)-ginsenoside Rg3 in heart failure TGFBI PMC12231332__F3 Relationships between pro-inflammatory cytokines and bone signaling pathways affecting osteoblastogenesis and osteoclastogenesis IGF1 RUNX2 NFATC1 SOST MMP9 CRP SMAD4 TRAF6 IL1B PMC8592284__F4 Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application SLC7A5 EP300 MAPK8 FOXO3A ATF4 ACLY MSRA GLS PMC7527140__F2 Deduced sterol biosynthesis pathways in Symbiodiniaceae DHCR7 EBP IPP PMC4012865__F9 Activation of DCs by HKBA showing the stimulation of TLR2 and TLR9 and cross-talk between their respective signal transduction pathways TLR9 MYD88 TNF PMC4388554__F11 Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL BCR GSK3B PTEN MTOR HES1 PMC4262066__F3 Schematic presentation of mechanisms leading to cell cycle deregulation in growth plate dtd chondrocytes CDK4 CDK6 PMC8468939__F8 Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells EGF EGFR STAT3 PMC7001001__F4 Bioinformatics Analysis of miR-124-3p and Its Downstream Targeted Genes(A) The genetic interaction network of miR-124-3p built by Biovista Vizit ROCK1 ANXA4 FMR1 ITGB1 RYR2 FZD5 FLOT2 SGMS1 RELA GRB2 CTNND1 FURIN SHC1 PMC5582996__F1 Configuring a robust nervous system with Fat cadherins VASP HOMER1 APP ATN1 DCHS1 FAT2 FAT3 FAT4 PMC3693462__F1 BRCA1: A Missing Link in the Fanconi Anemia/BRCA Pathway PALB2 BRCA2 BRCA1 RAD51C USP1 PMC7847682__F1 External and intrinsic mechanisms to mediate immunotherapy resistance for CSCs in HCC CD47 APC CCL20 PMC6618483__F8 Model describing Etv4 and Etv5 induction following distal NGF stimulation NGF ETV4 ETV5 PMC3591264__F7 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression RPS4X RPL38 RPL35 RPL37 HEL-S-310 RPL13 RPSA RPS29 RPL39 RPS24 RPS10 RPL31 RPL12 RPS5 RPL36A RPL29 NOP56 RPS2 RPS27A RPL27A RPL3 PMC4409526__F4 Diagram depicting molecules involved in actin cytoskeletal regulation mediated by NMDA signaling pathways and having altered mRNA expression in bipolar disorder ARHGEF7 DBN1 ROCK1 ACTN2 HEL-S-15 ARHA RAC1 CDC42BPA OPHN1 PRKCA PPP1R9B HEL32 PPP1CC PPP1R9A KALRN PFN2 CDC42 PMC3591264__F6 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression UBB HEL-S-66p PMC4409526__F3 Diagram depicting altered mRNA expression of molecules involved in the regulation of the actin cytoskeleton by NMDA signaling pathways in schizophrenia LIMK1 MARCKS DBN1 ROCK1 ACTN2 HEL-S-15 OPHN1 PRKCA PPP1R9B HEL32 PPP1CC PPP1R9A KALRN PARD3 CDC42 PMC7392137__F1 The original model for Wg signaling in Drosophila, the core of the current model for the canonical Wnt signal transduction (the Wnt/Beta-Catenin pathway) APC GSK3B LRP5 LRP6 ELL PMC7392137__F2 Two well-known non-canonical Wnt signalling pathways, including Wnt/Ca2+ (right) and Wnt/PCP (left) DAAM1 ARHA RYK ROR2 RAC1 JUN ROR1 PMC3386597__F4 AhR-related signaling molecules are enriched within the AML Signalisome PLK2 KAT2B ATL1-beta ATP1B1 ADAM19 DNMT3B CDK6 MAF CBX2 AHR MMP2 PHC2 RORA ENTPD1 PMC3386597__F3 AML Signalisome RPLP2 ATL1-beta ZNF263 ASPH HUNK COLEC12 MYH10 ADAM19 TRPM7 MAF CBX2 HEL-S-108 FAU AHR SNTB2 LUZP1 BACH2 MMP2 PHC2 ZNF618 HTT RNF141 HNRNPA2B1 PALM MED1 NFIA FRAT2 CENPA GNE KAT2B NKX2-3 PIR ELP2 MXD3 RPS25 SLC37A3 GFER SPOCK1 CASQ2 RORA OSM MGA PMC3819341__F1 Summary of therapeutic invention points in the myostatin signaling pathway ALK SMAD2 SMAD4 MTOR FSTL3 PMC5808457__F1 Tumor Suppressor Candidate 2 (TUSC2; FUS-1) and Human Cancers EGFR MDM2 TUSC2 PMC4905210__F1 Targeting the mevalonate pathway using statins and its feedback loop using dipyridamole induces tumor cell apoptosis LDLR HMGCS1 HMGCR PMC4428041__F3 Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease USP12 ATOH1 USP28 ITCH PMC2639036__F1 Single-strand break repair pathways FEN1 SSB POR OGG1 PNKP PCNA PMC4168797__F7 Paraquat hijacks the PPP to induce oxidative stress and cell death OGDH HEL107 HEL-S-68p HEL-S-162eP GLS PMC4515436__F12 Short range signalling between germline stem cell and its niche RET GDNF GSC CSF1 PMC6874879__F2 LKB1 loss alters cancer cell biology MFN1 TSC2 ULK1 MFF KEAP1 MTOR PMC6874879__F1 LKB1-proficient tumors display coordinated control of metabolism, DNA repair, and mitochondrial dynamics TSC2 MFF MTOR STRADA PMC7177879__F2 Regulatory network controlling SE induction in which the auxin-related epigenetic processes play a central role ARF5 TPR ARF6 ARF3 PMC5835590__F9 Summary of the main differences between NE high and low subtypes of SCLC NKX2-1 ASCL1 YAP1 MYC REST ASCL2 NEUROD1 DLL3 PMC8614792__F4 MicroRNA Sequencing Analysis in Obstructive Sleep Apnea and Depression: Anti-Oxidant and MAOA-Inhibiting Effects of miR-15b-5p and miR-92b-3p through Targeting PTGS1-NFKB-SP1 Signaling ATM CDK2 HEL-S-11 CD2 CHIC2 CDK4 PTEN ATR GATA4 PMC10223772__F5 Proteins related to resistance in HIGS lines infected with A. flavus MYB CERKL ERF TF PMC5367635__F1 Metabolic reprogramming in T cell fate and function IL7R MTOR TG PMC7488620__F7 Parental RHC reverses ischemia-induced changes in rod phototransduction pathway proteins CNGA1 SAG GNB5 OPN1SW ARR3 GNGT2 RHO PDC GNB3 PDE6C GNAT2 GNAT1 RCVRN GUCY1B1 GUCY2D GUCA1B GNB1 PDE6D GUCY2F PMC10390225__F2 Mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis HEL-S-62p CD14 IL6 FCAR PMC7373735__F1 General mechanism of ferroptosis associated with lipid, amino acid, and iron metabolism GPX4 LPCAT3 STEAP3 ADA CP PMC8662361__F6 Aging Affects KV7 Channels and Perivascular Adipose Tissue-Mediated Vascular Tone SDHC CS ACACA ADFP RXRG HEL60 HEL-S-32 MDH2 RXRA UBC MAX FADS2 PLIN5 ACO2 NR1C2 SUCLG1 FABP5 PIK3R2 SDHB FASN PMC4987476__F8 Graphical summary of anti-inflammatory activity of bee venom in LPS-activated BV2 glial cells TLR4 IRAK1 TRAF6 MYD88 PMC8395232__F1 Mitochondria-Induced Immune Response as a Trigger for Neurodegeneration: A Pathogen from Within TBK1 CGAS IL16 TLR9 STAT2 IRF9 IRF3 AIM2 PMC3468610__F4 Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing PIK3CD PIK3R1 CHUK HGF MYC RALA SMAD4 PTEN RALBP1 FGFR2 PDPK1 PLAT FRS2 HGFAC hEMMPRIN JUN TNFRSF10C BAX PLG FOS MAP2K2 RXRA PEMT CASP3 TIAM1 NFKBIA CDKN2B RELA TNFSF10 GRB2 TP73 REL PPARG FADD AKT3 PMC8220211__F6 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment STAT4 PMC3262999__F1 Interaction between Jak2/Stat5 signaling and the PI3K/Akt1 pathway in mammary epithelial cells PRLR SRC PTEN PRL PMC8220211__F3 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment STAT4 PMC7393602__F1 Nav1.5 promotes the activity of NHE-1, resulting in the acidification of the peri-membrane, which favors the proteolytic activity of Cat and MMPs (yellow line) SNAI1 CD44 RAC1 PMC6721482__F2 The regulation of Keratin 6, 16 and 17 during skin wounding and in psoriasis STAT1 EGFR IL22 TNF MTOR TLR3 IFNG STAT3 PMC2878914__F1 Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway NR1i1 EBP PMC3340364__F6 Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells CASP3 CASP9 ATR PMC6704427__F1 Genetic abnormalities in HNSCC contribute to poor tumor immunogenicity SOX2 PIK3CA MTOR PMC5661397__F6 Pentose phosphate pathway (dotted lines) and associated metabolic pathways (solid lines) SORD HEL107 PMC5866017__F6 Enriched pathways in cholangiocarcinoma GNB2 PTN RBBP4 POR E2F3 CCNE1 FYN KHSRP GBP2 CASP9 FAT10 EZH2 PRKDC EGR1 ARHGEF1 NONO FOS CXCL10 NR3C1 CAND1 PARP1 MCM7 RAC1 GRN HDAC1 NEDD4 HEL-S-162eP MCM3 MCM2 RAE1 RAF1 TRAF2 PNKP PMC7141137__F3 Intracellular regulators that link morphogen signaling pathways during DV and AP patterning of the ectoderm in vertebrate embryos FOXB1 SIX3 CLK2 PMC8601834__F2 Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases TRADD APAF1 RIPK3 TNF FADD BAX PMC2713381__F8 MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway PDK2 GRB2 RAF1 PMC6831629__F8 Hypothetical model to depict the role of Trpc1 channels in linking the inhibition of BMP pathway by noggin, and the activation of Cav1.2 channels in ectodermal cells TRPC1 SOX2 ZIC3 PMC6597298__F7 Schematic diagram showing the critical role of FDPS in normal prostate and prostate cancer and its associated potential mecahnism (s) STAT1 FDPS PTEN PMC7330943__F8 Estrogen signalling pathway (a) is solid active instead, prolactin pathway (b) results are not in the group of the strongest expression level TH SOCS2 CHUK SOS2 FOS ATF2 HSPA2 NRAS HRAS MAPK13 KRT27 MMP2 PRLR RAF1 MCL1 KRT28 SOS1 KRT39 KRT14 PMC5519011__F3 redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models ME1 PIG59 ME2 CS MALL HEL-S-11 CIT TNLG7C MAL PMC4408933__F3 Adipocytokine signaling pathway as represented in the Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/kegg1.html) (; , ) SOCS3 TRADD NPY AgRP LEPR MTOR TRAF2 NR1C1 STAT3 PMC2564730__F3 Use of MIMO models to infer regulatory interactions in breast cancer cells EGF IGF1R EGFR MTOR PMC9006445__F3 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies GPX4 TRADD AQP1 SLC7A11 RIPK3 MTOR RIPK1 CDO1 CDK2 SLC3A2 ATR FADD MLKL PMC9006445__F2 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies ULK1 AMBRA1 ATG101 ATG14 PMC8632930__F1 Antitumor effect of PARP inhibitors PALB2 ATM BRCA2 SSB RAD51 CHD2 XRCC3 BRCA1 PMC6995234__F7 Expression of genes in central metabolic pathway in wild-type (WT) and engineered M FBP2 PDC FBP1 FH OGDH RPE TK1 HEL-S-162eP PMC9006445__F1 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies TRADD TRAF2 FADD STAT3 BAX PMC4211430__F7 Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice IHH SMO CCKBR PMC4959089__F1 General schematic model of a NR signaling pathway PC HP GC PMC6948370__F11 Diagramatic representation of the possible molecular mechanism of CXXC4-mediated tamoxifen resistance APC GSK3B LRP5 CCND1 LRP6 CDK4 CDK6 CXXC4 PMC9258696__F1 Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis CTSK NFATC1 MMP9 PMC8523237__F1 Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine NLRP3 NLRP1 AIM2 DMD PMC10305000__F6 Reconstructed fatty acid synthesis pathway of ST7-B DLD GPD2 DLAT PMC8787129__F11 Liver Fibrosis—From Mechanisms of Injury to Modulation of Disease RHO PMC4954849__F1 Interplay between VEGF and Notch signaling is important for tip and stalk cell differentiation in physiological angiogenesis DLL4 PMC8946298__F3 Cross-Talk between p53 and Wnt Signaling in Cancer APC AXIN1 TCF4 PMC3646015__F6 Developmental Gene Discovery in a Hemimetabolous Insect: De Novo Assembly and Annotation of a Transcriptome for the Cricket Gryllus bimaculatus SUFU SMO PMC9006445__F4 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies NLRP3 PRKCQ TRADD EGFR CCR7 SRC FADD GSDMD STAT3 BAX DFNA5 PMC5533789__F6 Hypothetical signalling network and status in bovine cumulus cells modified by FSH-priming based on RNA-seq expression signature IRF7 TNFAIP6 HAS2 TGFB1 PTX3 PMC7869011__F4 Retinoic acid (RA) synthesis and signaling activation during in vitro cardiac differentiation RARA RARB RBP1 LRAT RBP4 RXRG RDH10 PMC11545013__F10 Elevated RBP4 in Subclinical Ketosis Cows Inhibits Follicular Granulosa Cell Proliferation and Steroid Hormone Synthesis RBP4 CCND1 CDC2 CYP17A1 STAR CYP27B1 CCNE2 BAX PMC6593264__F2 Dual aspects of GM-CSF immunomodulatory effects TH CD33 CX3CR1 CD40 PMC7053436__F5 Central role for Ras-MAPK signaling in habituation learning BRAF CASK SHANK3 CC2D2A COG7 PTEN PACS1 POGZ DMPK NF1 AP1S1 MANBA ZEB2 COX10 PTPN11 ARX AP1S2 ADK EHMT1 RNASEH2A HRAS GRIK2 LAMA1 TSC1 WAC CACNA1G NRXN1 ERCC2 PMC3136877__F1 mTOR signaling cascade in the pathogenesis and prevention of skin cancer TSC2 TSC1 MDM2 PTEN RHEB PMC9418006__F7 Metabolic pathways encoded by Comchoano-1 and Comchoano-2 consolidated from Pathway Tools DAP DES PMC7912095__F2 Loss of LKB1 drives the tumor immune escape CCL5 EZH2 CXCL12 PMC2926929__F1 The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin AGK LPA LPP PMC8321592__F1 Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants RNF43 BRAF POLE APC AXIN1 PIK3CA PCBP1 SOX9 PMC8461181__F3 GnIH in Biological Rhythms and Social Behaviors PMC6957567__F1 Brief overview of DDR signalling PALB2 ATM BLM TOPBP1 BRCA2 ATRIP RAD51 ATR H2AX MRE11A DNA2 BRCA1 PMC5123406__F1 Conceptual model of viral integration ATM RAD51 ATR BPI BRD4 PMC6299275__F3 Canonical pathway analysis using MetaCore identified EGFR, PDGFR, and mTOR signalling as the top 3 canonical pathways modulated in FCD type II patients TTI1 EGF MAPKAPK2 PTMS TLR4 AGTR1 EGFR GHR TRAF6 MTOR DEPTOR PDPK1 PMC4872954__F1 Obesity versus osteoarthritis: beyond the mechanical overload LEP TRADD TRAF6 MYD88 JAK1 MAP3K7IP1 TRAF2 STAT3 PMC5833784__F2 Immunological consequences of kidney cell death RIPK1 RIPK3 MLKL PMC6856869__F4 Recognition of HSV-1 infection by pattern recognition receptors (PRRs) CGAS IRF7 IRF3 IFI16 PMC6765066__F7 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases HMGB1 TLR4 SMAD2 FGF2 CXCL8 STAT3 MAL PMC8897942__F1 MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy MUC1 MTOR STAT3 PMC8888544__F5 Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice HEL-S-62p EGFR ALB CDKN2A ORM1 STAT1 TLR4 AHR JUNB CSF2 NR1H3 JUN IL1B CFB HBEGF IL6 CBL ITGAM NFKBIA HP NFKB1 RELA IL23A GRB2 MAP3K8 CSF1 OSM PPARG CASP4 BRD4 PMC3532456__F3 Interleukin (IL)-13 and IL-4 signaling pathway IL13RA2 IL13RA1 TYK2 JAK3 JAK1 STAT3 PMC3532456__F2 Transforming growth factor (TGF)B signaling pathway PLG TGFBR2 ARHA PMC8471880__F2 Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism NLRP3 STAT3 PMC6555274__F4 TGFB signalling pathway with FOXN3 BAMBI FST NODAL PITX2 SMAD4 FOXN3 SKP1 ARHA SP1 RBX1 LTBP1 IFNG PMC7642035__F6 Therapeutic Interaction of WNT Pathway Activation and Asparaginase APC PMC4091806__F1 A New Lnc in Metastasis: Long Non-Coding RNA Mediates the Pro-metastatic Functions of TGFB ZEB2 STAT3 PMC7094958__F2 RIG-I-like receptors: their regulation and roles in RNA sensing TBK1 IRF7 IRF3 MAVS PMC6642071__F1 Methionine–homocysteine cycle and biosynthesis of betaine HEL-S-61p MSRB2 CHDH MSRA MSRB1 PMC5331612__F1 ChREBP regulates fructolytic gene expression PKLR KHK FASN PMC1183479__F8 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) TSC2 TSC1 EIF4E MTOR PMC7863575__F1 Steroidogenic pathway SULT2A1 CYP11A1 HSD3B2 SRD5A2 CYP17A1 CYP21A2 STAR PMC7348953__F1 Therapeutic Targeting of the Wnt Signaling Pathway APC GSK3B LRP5 LRP6 PORCN TNKS PMC5267499__F1 Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins BAD SRA1 TES POR MTOR UNG PMC7094958__F4 RIG-I-like receptors: their regulation and roles in RNA sensing TBK1 OASL IRF7 CYLD NLRP12 SFPQ IRF3 DHX15 ZCCHC3 TRIM25 MAVS RNF125 PMC5097370__F4 Regulation of myofibroblast formation by TGFB1 SMAD2 SMAD4 JUN PMC4435618__F2 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans TSC2 TSC1 FOXO3A GRB2 EIF4E BNIP3 EIF4EBP1 MTOR PMC4435618__F1 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans GSK3B GRB2 PMC7918075__F4 Putative model for the involvement of cell signaling pathways in the induction of survival by type I (A/B) and II (G) IFNS in CLL cells SRC TYK2 JAK1 STAT3 PMC4287622__F4 Protein Interactome of Muscle Invasive Bladder Cancer CDKN1A COL3A1 EGFR CCND1 CDK4 RAF1 THBS1 HRAS CDKN2A JUN PMC8021683__F1 Summary of signaling pathways regulating cardiomyocyte proliferation ERBB4 ERBB2 APC GSK3B CCND1 NRG1 LATS2 CDKN1C TF PMC4287622__F3 Protein Interactome of Muscle Invasive Bladder Cancer PRKCZ BAD EGFR TGFBR1 TGFBR2 PTEN PRKCA ERBB4 COL4A6 KDR PDGFA MDM2 MAPK1 CDK4 THBS1 ARAF JUN LAMC2 BAX CDKN1B PTGS2 FGF2 ERBB3 VEGFA FGFR3 LAMB3 HRAS LAMA3 CASP3 TNC ITGB4 CDKN1A ERBB2 CDK2 ITGA6 GNAI3 CTNND1 BCL2 HEL-S-93 LAMC1 BDNF MYLK PMC4538335__F1 Lesser-Known Molecules in Ovarian Carcinogenesis ERBB2 SRC TNF MTOR PMC2955921__F2 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway SPR SSB PCNA PMC8008798__F1 General scheme illustrating the potential mechanistic pathway of Notch signaling in the pathogenesis of pulmonary fibrosis MAML1 RBPJ MAML3 MAML2 PMC8349779__F2 Reprogramming of TCA cycle, fatty acid and glutamine metabolism in renal cancer COX2 ABAT MYBBP1A FH MYC LPA HEL-S-5 GLS PMC8349779__F1 Reprogramming of glucose transport and glucose metabolism in renal cancer PC EZH2 HEL107 STAT3 PMC11663741__F10 Hypothesized immune mechanisms of fish spleen against N PIK3CD FTH1 FTL PLCG2 CLEC4E MYD88 CD79B CXCL13 NFATC2 CD22 ZAP70 PRF1 C1S ACSL3 CP PMC6592250__F5 Coordinated interactions between glycolysis, citrate cleavage enzyme, and glutaminolysis for the fatty acids biosynthesis in growing tumor cells HEL-S-26 NNT PMC6283168__F3 Triacylglycerol (TAG) lipolysis in Drosophila: biochemistry and main regulatory pathways PLIN1 ADFP SIK3 PMC7215558__F2 Autophagy and UPS alterations bridging altered proteostasis with neuroinflammation, the paradigm of protein glycation MTOR PMC3439854__F2 Transcriptional regulation of PDPN expression STAT1 FOS SMAD2 SMAD4 PDPN PTEN JUN IL1B STAT3 PMC6283168__F2 Triacylglycerol (TAG) synthesis in Drosophila: biochemistry and main regulatory pathways GPAT4 DGAT2 AGPAT3 PCYT2 LPA FASN PMC12114829__F1 Biosynthesis of BRs in plants H1-6 PTS MPO CP PMC4580081__F2 Interactions of chaperone proteins with Stat3 panel (A) and Jak2 panel (B) CDC37 JAK1 STAR PMC6903413__F5 NFKB activation in inflammatory cells NLRP3 IL18 IL16 TRADD VCAM1 IL6 MYD88 TRAF2 PMC6903413__F4 NFKB pathway in pancreatic acinar cells CCK IL6 TNF PMC4315934__F4 Cardiac muscle contraction and changes with exercise HGF IGF1 GATA4 PMC3430718__F7 SOCS1 regulates the IFN but not NFKB pathway in TLR-stimulated human monocytes and macrophages TLR4 IRF3 IRF-1 SOCS1 MAL PMC3870464__F2 Protein components of the pheromone response network constructed by the PCST approach CDC20 CCR4 INS ARAP1 ACE2 TF PMC1133850__F10 Vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication EGR1 ATF1 PMC5114008__F2 Adaptive Stress Responses During Tumor Metastasis and Dormancy ATF4 EIF2A UNK PMC8276772__F1 Centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation EPO NCOR1 NPM1 CTCF BMI1 PTEN RHO MTOR TET1 PRC1 SRC ASCL2 NCOA1 NCOR2 POLI NPM2 CCL11 HOPX OLFM4 BRCA1 BCL6 BCOR PAK1 HP GRB2 OSM PMC7181577__F7 Proposed effect of NgR reduction on APP traffic to lysosome through Rho/ROCK2 pathway ARHA LINGO1 PMC8945922__F7 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components ATG12 ATG3 IGF2 MCU ATG10 BAX PMC4540028__F3 Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree ADA MVK DDT IPP PMC8945922__F5 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components TIGAR TSC2 ATG3 ATF4 EIF2A PTEN MTOR ATG14 RHEB PMC9652280__F4 Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome MOK LAT PMC9663771__F2 Angiopoietins in Neovascular Diabetes-Related Retinal Diseases ARHA RAC1 PMC8663872__F7 To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology TH BAD MYC LTA MAX MAFK RAF1 GAL MGA FADD LAT TIRAP STAR CDC42 ITCH CD19 PMC3428775__F3 Model depicting effects of Wnt-stabilized Beta-catenin through Tcf proteins in mESCs TCF3 SOX2 PMC10468808__F2 Activation of NFKB and MAPK signaling pathways regulates the expression of catabolic factors TRAF6 TNF TRAF2 PMC2727709__F1 Multiple previously established signaling cascades in activated mast cells with quantitative proteomic data from MCP5 cells represented as heatmap bars beside individual proteins BTK FYN PC IL3 GAB2 LYN GRB2 SRC SYK TYK2 PMC7855580__F2 Systemic inflammatory response from SARS-Cov-2 may trigger atherosclerosis HEL-S-62p NLRP3 TNF PMC2795398__F1 Endotoxin binds to CD14 and Toll-like receptor 4 (TLR4) on the surface of monocytes and endothelial cells CD14 COX2 TLR4 MYD88 TNF PMC4110479__F3 Tolerogenic properties of plasmacytoid dendritic cells (pDCs) TLR7 TLR9 AHR SRC CD40 CD80 JAK1 CCL22 TSLP ICOS STAT3 FOXP3 PMC4110479__F2 Proinflammatory properties of plasmacytoid dendritic cells (pDCs) TBK1 TLR9 IRF7 IRF3 NOD2 TLR3 TLR8 TLR7 TLR4 NOD1 SRC TYK2 JAK1 IL1B STAT3 PMC4428674__F1 Mediators released from activated MCs HEL-S-62p KIT LTB KITLG IL1B PMC5814196__F1 Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer BAMBI NLK INVS SIAH1 APC SOST NOTUM CER1 SMAD4 LRP6 SKP1 ARHA PMC7533603__F4 Modeling the metabolic modifiers of T-cell function in Tconv and Treg, showing differential impacts of glycolysis and oxidative phosphorylation on each and the role of the mTOR pathway in mediating this RPTOR FOXP3 PMC4295541__F2 Generation of ceramide and FTY720-P CERS3 LASS1 DES CERS5 CERS2 CERS6 PMC8476624__F6 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study AFP F10 REN F9 BTD ALB A1BG APOC3 AMBP ORM1 HMFT1766 SERPINC1 HBA2 F2 RBP4 SERPING1 KNG1 APOA2 PGLYRP2 C1RL AFM APOB HEL111 HP ORM2 AHSG HBB BDKRB2 APOH CP PMC8476624__F5 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study PGLYRP2 C1RL BTD ALB A1BG CENPF AFM AMBP ORM1 HMFT1766 HBA2 HEL111 HP ORM2 AHSG HBB RBP4 SERPINA1 KNG1 APOH APOA2 CP TF PMC5908130__F5 Perturbed gene network in placenta that may be reflected by the changes of circulating miRNAs in PTL PRKCA TNC TJP1 VASP FYN KDR MYC SRC TNR PTEN HEL114 MTOR PMC2894843__F3 Ingenuity Pathway Assist (IPA) analysis of significant genes involved in cell death CTSL CASP3 DCN IL18 NLRC4 ATM PTPRO FGF2 MYD88 CSF2RB STAT3 PMC7324605__F5 Polyamine pathway in patients with Diffuse Cutaneous Leishmaniasis SRM SMS PMC8024183__F7 The differentially expressed genes mapped in p53 signalling pathway, which are upregulated after radiation exposure (highlighted in red) ATM ADA ATR AMT PMC8541835__F1 RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis PMC6146604__F1 Lignin biosynthesis HEL-S-62p CS CAD HEL107 RPE PMC2746245__F2 Toll-like receptor (TLR) pathway TLR8 TLR5 TLR7 TLR4 TRAF6 MYD88 IL1B TLR3 PMC7744622__F4 Roles of p53 and PTEN signaling pathways in the regulation of autophagy TIGAR TSC2 ULK1 TSC1 MAP1B AMBRA1 ATG101 PTEN MTOR ATG14 RHEB MLST8 PMC7744622__F3 Major signaling pathways involved in the regulation of autophagy ULK1 AMBRA1 AAMP PTEN ATG101 MTOR RHEB MLST8 TSC2 RICTOR PI3 TSC1 ATG14 PMC8613976__F1 NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity NLRP3 MYD88 GSDMD PMC2746245__F6 Injury-induced changes in the nociceptive pathway CXCR3 CCR5 CCR2 IL16 CXCR4 TRPV1 PMC10519534__F8 DZP active constituents on myopia through the “AGE-RAGE diabetic complication signaling” pathway MMP2 SMAD4 CDK4 TF SELE STAT3 BAX PMC7867275__F1 Heme synthesis pathway and mechanism of 5-aminolevulinic acid (5-ALA) fluorescence CPOX EGFR ABCG2 PMC11171322__F8 Graphical overview of representative exclusively differentially expressed genes from our RNA sequencing data in the myeloid and lymphoid group that are clearly assigned to the BMP/TGFB signaling pathway TGFBR3L IRAK1 GSK3A TNFRSF19 TNFRSF11B TNF FZD9 COL9A2 IBSP MSX2 IRAK3 TGFB1 FADD COL4A2 COL8A2 PMC5790522__F7 Transcriptome profiling identified differentially expressed genes and pathways associated with tamoxifen resistance in human breast cancer PIK3R1 CRISP3 ATF2 HSPA2 CREB1 ART3 ATP6V1C2 PI3 MMP2 SRC KCNJ5 SP1 CREB5 NPY1R DHRS13 PRSS27 SOS2 ABCA13 ADCY1 C2CD4D CREB3L3 LYPD5 HBEGF MAGEC1 MTMR11 CALML4 KCNJ9 PRSS33 SOX8 HRAS PIK3R3 ADCY3 GABRP PRKACG CREB3 PLCB1 KCNJ3 CALML6 CALM1 PLCB2 SHC2 GABBR2 GABBR1 GNAI3 GRB2 SIX3 ADCY6 SHC4 GNAO1 HSPA1A ARNT2 AKT3 ADCY9 PLCB3 CREB3L2 NR3A2 HSP90AB1 EGFR PTPRN2 SHC3 GNAI1 GNG4 ATF4 KCNJ6 FKBP4 ATF6B JUN CNTN5 MGAM GRB14 OPRM1 MMP9 FKBP5 MAP2K2 ADCY8 MUC2 HEL-S-125m MAP2K1 CST4 ELOVL4 RAF1 GNAS CALML3 GFRA3 PIK3R2 PMC7363309__F1 Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1A,25(OH)2D3: application in a pediatric population CYP27A1 CYP24A1 CYP27B1 PMC5382784__F1 Schematic illustration of extracellular oligopeptide metabolism in P DPP4 PTPA DPP7 PMC8524104__F1 Lactate in the tumour microenvironment: From immune modulation to therapy MTOR HEL-S-133P HEL-S-281 HEL-S-162eP PMC3446895__F5 Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells BTG3 GADD45A PMC7916160__F2 Overview of phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway and inhibitors PTEN EIF4E IRS1 RHEB PMC10915960__F1 Preconditioned mesenchymal stem cells with high therapeutic potential in various pathologies MSC PMC11841260__F3 Application of spatial transcriptomics to rheumatoid arthritis MMP3 FAP S100A8 CD200 IL6 PMC9681882__F3 Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways APOD CNDP1 THBS4 COMP PMC7059589__F2 Neuronal roles of atypical protein kinases (aPKCs).(a) aPKCs mediates nerve growth factor (NGF) response NGF GULP1 GSK3B LRP5 HEL-S-44 LRP6 MTOR IRS1 PMC8535591__F2 Insulin-like Growth Factor 1 Signaling in Mammalian Hearing ULK1 BAD IGF1R FOXM1 GSK3B ATG101 RHEB TSC2 TSC1 IGF1 CDK2 GRB2 CCND1 PMC6113426__F3 Summary of apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like (APOBEC)3B transcriptional regulations in cancer cells E2F4 PC ATM RELB LIN9 TNF ATR PMC7164249__F1 Merlin regulates different developmental signaling pathways APC EGFR ERBIN RAC1 CDC42 PMC2814006__F1 IL-1 and TNF signal transduction events TRADD IRAK1 TRAF6 MYD88 TNF MAP3K7IP1 TRAF2 TAB3 PMC4626744__F2 Enzymes involved in PGE2 synthesis and metabolism HPGD PTGS2 PTGES AKR1C1 PLA2G5 PLA2G2A AKR1C2 PTGS1 PTGES3 PMC4626744__F4 PGE2 synthesis, action, transport and metabolism in granulosa cells HPGD PTGS2 PTGES SLCO2A1 PMC9611771__F3 Identification of differentially expressed genes in mouse paraspinal muscle in response to microgravity TH BAD PLEC APP DES GAL LAT PMC4872542__F9 Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro CASP3 GSK3B CASP9 CASP8 PMC2882184__F1 Pathway analysis using all altered genes and proteins STAT1 ITGB3 RBBP4 HEL-S-28 EGFR MSH6 HBB RPL26 BMI1 HOXA10 RPS16 IRF-1 PMC3119709__F1 Macrophages as a Battleground for Toxoplasma Pathogenesis SOCS2 IL23A IL6 CSF2 ARG1 STAT3 PMC4383688__F1 Molecular Pathways: Aspirin and Wnt Signaling—A Molecularly Targeted Approach to Cancer Prevention and Treatment APC MYC LRP5 LRP6 TCF7L2 PMC8111291__F8 FOXC1 Negatively Regulates DKK1 Expression to Promote Gastric Cancer Cell Proliferation Through Activation of Wnt Signaling Pathway APC LRP5 LRP6 PMC8027476__F6 Schematic diatgram of CAFs induced renal cancer progression AIP AHR SRC STAT3 PMC5109916__F1 Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3 GSK3B PTEN PMC4060523__F2 Signaling pathways that positively regulate ecdysteroidogenesis in the PG in Drosophila melanogaster TSC2 TSC1 SMAD2 PMC12239316__F6 Genetic model for evolution from all-black to all-white yak KIT MAP2K1 DCT TYRP1 MAP2K2 PMC8834284__F1 Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster PGM3 OGT PMC4461826__F1 Mammalian cells employ two principal DNA double-strand break (DSB) repair pathways PALB2 ATM BLM RAD51 ATR BRCA1 PMC6019448__F7 Avian and mammalian OASL involvement in RNase L and RIG-I signaling RNASEL OASL MAVS CARD14 PMC3435458__F7 RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells TRADD TNF FADD RGS10 PMC3258432__F6 Factors shown to promote or inhibit the vascular normalization phenotype in tumors PIGF PDGFD RGS5 PDGFC NRP1 EGFR VEGFA MTOR RHOB PMC7578900__F7 Signal pathway of PIO on mitochondria‐mediated apoptosis in cisplatin nephrotoxicity SIRT1 BAX PMC4564205__F3 Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49 CS MVK IDI1 ACOT11 CIT IPP GGPS1 HMGCR HEL-S-162eP PDC PMVK PC MVD FH RPIA ACD HEL107 RPE GLA MAL PMC2808176__F1 Example of pathway segments corresponding to FALZ identified from breast cancer data (Figure drawn with Cytoscape) MUC1 MYB PIG59 YBX1 FBP1 TES ERBB3 CCNH TAF9 EVL XBP1 IRS1 IKBKB PLAT JUP BCL2 IL6ST XPA TSNAX PMC2722219__F1 The TSC/mTOR signaling pathway NF1 TSC2 TSC1 PTEN MTOR IRS1 RHEB PMC6700727__F5 In vivo induction of demyelination by direct Mycobacterium leprae injection into sciatic nerves ERBB2 LCK PMC8750547__F1 Long Noncoding RNAs Regulate the Inflammatory Responses of Macrophages TLR4 CIC TRAF6 MYD88 PMC9367915__F2 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer ATM ERG TLK1 NOTCH1 SPOP PTEN ATR LATS2 NEK1 PMC8308723__F1 Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial RUNX2 SMAD4 SMAD1 DKFZp781O1323 PMC4652152__F8 Comparison of gene networks affected by ozone exposure in males and females CD14 CXCL1 TLR5 FOS CXCL5 PTGS2 CXCL10 LTB CXCL3 CCL4 CCL2 IFNG IL18 LTA CD40 CD40LG NOS2 CAD CSF1 PMC4652152__F7 Ingenuity Pathway Analysis for inflammatory gene expression in females vs CD14 TLR4 TLR9 LY96 TLR1 TLR3 IFNG PMC9367915__F1 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer ERG MYC PTEN LATS1 BRCA1 LATS2 WEE1 ATM BRCA2 TOPBP1 ATRIP STK4 CDC2 ATR PMC2826600__F4 Insulin and IGF1 signaling pathway to promote glucose uptake by GluT3 in neurons (shown) or GlutT4 in muscle (not shown) PLTP IGF1 KEAP1 MTOR PMC11121248__F7 Two separate mechanisms for the role of MerTK and ENG in TNBC progression MYC ENG MERTK PMC5937133__F1 Type 1 diabetes pathogenesis and B cell protective factors APC TNF IFNG PMC6163247__F2 Endoplasmic reticulum (ER) and mitochondria interactions BAD AIP BCL2 LASS1 MCU CERS6 BAX PMC6163247__F1 Metabolic implications associated to ceramide synthesis DES CD36 PMC7591521__F6 CsIVa-mediated inhibition of miR-155/GSK-3Beta-NFKB signaling pathway CD14 TLR4 GSK3B IL1B PMC9343252__F7 MiR-146a targets CD147 in ALK+ ALCL promoting increased energy metabolism ALK CEBPB STAT3 PMC9294232__F1 Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma HEL-S-62p EGF SMAD2 EGFR SMAD4 TRAF6 COX2 ATM CDK2 PRMT6 CDH2 ABCB1 PCNA BAX PMC3805541__F3 MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214 KIT PRKCE NFAT5 FOS VEGFA IL24 MAP2K3 MTOR BMF XBP1 DDIT4 POU4F2 HOXB5 TNFSF10 TIMP3 ACSL1 EZH2 MED1 BNIP3 NR3B3 INHBA SELE PMC5482989__F7 Proposed mechanisms for crosstalk between AR and GDNF signaling and inhibition of prostate development by RET-mediated GDNF signaling RET GDNF PMC7843612__F6 TGFB pathway regulation by miR-331 SMAD2 SMAD4 CCND1 CCND2 PMC6952807__F1 TNFR1-mediated survival and cell death pathways RIPK1 TRADD CYLD RIPK3 MAP3K7IP1 TRAF2 CASP8 FADD MLKL PMC6105893__F10 Role of cFP as a virulence factor while in the host and also as a signal to induce expression of genes to protect the pathogen SET CFP ROS1 PMC4543283__F1 New pathway for memory B-cell activation in systemic lupus erythematosus (SLE) PDC BCR ICOS PMC7504726__F2 Antioxidant effect of quercetin on enzyme activity, signal transduction pathways and reactive oxygen species (ROS) MAF EGR1 BAX PMC7367293__F4 Ingenuity pathway analysis (IPA) of actin cytoskeleton signaling in the Xenopus laevis whole brain after exposure to the predatory salamander larva, Hynobius lichenatus EGF FLNA APC BAIAP2 APP SRC ABI2 HEL114 CRK PXN TRIO GNG12 PMC7367293__F6 CREB signaling in the Xenopus laevis whole brain after exposure to 24 h of a predation threat from the larval salamander, Hynobius lichenatus TBP GRB2 PMC3011108__F1 Schematic showing that when a cell membrane is injured the arachidonic acid pathway is activated to initiate the local inflammatory response through the production of prostaglandins, thromboxanes, and leukotrienes COX1 PMC5940296__F1 Latest advances in the interplay of physical and biochemical signaling pathways leading to transcription in the tumor microenvironment RET G3BP2 VCAM1 VTN GSK3B MYC PTEN AXIN2 PMC9096795__F5 Hereditary Systemic Autoinflammatory Diseases: Therapeutic Stratification JAK1 PMC11591163__F3 Mechanistic diagram of the Nrf-2/AREs signaling pathway KEAP1 AKR1B1 HEL-S-128m NQO1 PMC11591163__F1 Blood–brain barrier is severely damaged during ischemic stroke SQLE GPX4 STEAP3 SLC7A11 PSTK IPP PMC6357531__F3 Proposed model by which polyphenols may modulate oxidative stress-induced pathways including Ang II, VEGF and TNFA MMP2 MMP9 NOX4 MTOR SIRT1 PMC4920993__F2 Predicted FA and TAG biosynthetic pathways in perilla seeds DGAT1 PC DGAT2 LPA CP PMC6397698__F4 Mechanism of action for combined TGFB and PD-1 pathway inhibition TGFBR1 TGFBR2 IFNGR2 IFNGR1 IFNG PMC8349779__F5 Altered metabolic events in renal cell carcinoma (RCC) GC VHL LPA PMC6321920__F1 HPV induces, yet tolerates, replication stress (RS) to promote viral replication through the ATR-dependent RS response RRM2 CDK2 KDM6B PCNA PMC108819__F8 Signalling pathways for EGF activation of c-jun EGF GRB2 ATF1 MEF2D PMC12029499__F1 Vitamin D synthesis and activation pathway VIT CYP2R1 CYP24A1 CYP27B1 PMC11694028__F3 Interaction of FBXW7 with signaling pathways and key molecules in gastrointestinal cancers EGF EGFR APC SHOC2 PTEN MTOR FBXW7 MAP4 CDK2 ANXA2 NOTCH1 CDC2 BAX PMC3614663__F1 Diagram showing the crosstalk between the DNA damage response pathway and BMP-controlled osterix expression and osteoblast differentiation ATM MDM2 SMAD4 SMAD1 PMC6590643__F4 Simplified figure depicting the roles of RORC consensus pathway members, adapted from Yu et al RORC TH IL17F FOXP3 BATF BCL6 RARA IL23A IL-21 TGFB1 IRF4 SOCS1 STAT3 PMC2567351__F2 MAPK Signaling Pathway DAO MAX LAT PMC2567351__F1 T Cell Receiptor Signaling Pathway NPAT LCK GRB2 CDK4 LAT PMC4684475__F2 Inflammatory targets of therapy in sickle cell disease TRADD MYD88 TNF PMC4238899__F1 Organisation and lineage control in the intestine ATOH1 ASCL2 NEUROD1 PMC9498478__F5 Stress Response Mechanisms of Salmonella Enteritidis to Sodium Hypochlorite at the Proteomic Level PTS GATC ARG1 FIGN PMC7582682__F1 On the hematopoietic cell surface, transient receptor potential cation channel subfamily M member 7 (TRPM7) and magnesium transporter 1(MagT1) facilitate magnesium influx into the cell MAGT1 RUNX2 CCND1 MTOR IL1B TRPM7 PCNA PMC4808760__F6 Kinetic models describing the in vivo metabolism of the HDL apolipoproteins on each HDL size fraction APOM APOA4 APC APOC3 RPE APOA2 APOE PMC5745449__F1 Modular Schema of the Stress Response Network PDC PTEN ATP8 HIF1A MTOR PMC12009910__F9 Notch signaling pathway: curcumin can bind Notch-1 protein and the bHLH domain of Hes1 HES5 HES6 HEY2 HES7 HES1 PMC12009910__F8 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway APC LRP5 LRP6 NKD2 PMC6791470__F1 T Helper 9 Cells: A New Player in Immune-Related Diseases SMAD2 SMAD4 EZH2 IRF4 FOXO1 GATA3 FOXP3 BATF PMC12009910__F3 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway MAP3K7IP1 TAB3 PMC3773342__F5 Genes expressed higher in mutant mice revealed networks of interacting genes EGR1 ENPEP MAFF ASB1 ADD2 CD74 HLA-DMA CXCL13 RET ZFP36 EGR2 MAST2 HLA-DQA1 JUN PMC12009910__F2 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway KEAP1 NQO1 PMC11130833__F1 Molecular activity of BTK- and BCL2- inhibitors in CLL BTK BCR BASH LYN BCL2 SYK PLCG2 MTOR BAX PMC6475113__F5 EZH2 and Foxm1 as likely upstream regulators of PRLR-dependent gene expression ASF1B NINL CCNA2 E2F4 PLK1 PIM2 MYC PAX7 CENPF SAA1 GATA1 ATOH1 KLK3 SERPINA1 FAT10 EZH2 LRRC40 FLI1 SELENON HOXA9 PIP5K1C TNF LAMA4 BRCA1 KHDRBS1 HMMR CDKN1A PLEKHG3 FOXM1 CDKN2C PTEN TOP2A DNMT3B NGFR BIRC3 ZBTB16 KIF18A SFRP1 CDC2 BANP MKI67 NFYA CCNE2 GADD45G PDGFRA PLK4 TBXT SUZ12 CLPTM1L SPIB DNAJB11 SSR1 ENPP2 OXTR PRLR SMC2 KIF20A MAPKAPK3 HOXD9 CALML3 JAM2 ELL PMC5003019__F8 HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NFKB-YY1 pathway CX3CR1 CX3CL1 YY1 CR1 PMC3773342__F9 Proposed signaling process for GDNF-independent UB outgrowth NPY BMP2 GDNF BMP4 PMC5999746__F3 Reactive oxygen species (ROS) produce oxidative stress which in return converts the normal epithelium to early adenoma which leads to the next stage that is intermediate adenoma by the activation of EGFR signaling COX2 FOS EGFR GRB2 PMC2443854__F1 The Essential Components of Nodal SignalingTGFB proteins are synthesized as pre-pro-proteins requiring cleavage of the signal peptide (black) and prodomain (orange) prior to dimerization of active ligand (red diamonds) NODAL SMAD2 SMAD4 GDF1 FOXH1 PMC3637951__F7 FOXM1’s role in thyroid cancer PLK1 FOXM1 CCNB1 SKP2 AURKB PMC8630372__F1 Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine TSC2 PIK3R1 RICTOR TSC1 GRB2 PIK3CA PTEN MTOR DEPTOR RHEB PMC9271868__F2 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology LTA PLAA COX1 LTC4S TNF LPCAT2 ORAI1 STIM1 PMC9271868__F1 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology LTA PC GPR55 GPR101 LTC4S LPA GPR31 LGR6 LPCAT2 GPR37 PMC5991297__F7 Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose HMGB1 NFAT5 S100B JUN PMC2528845__F2 Intracellular signaling activated through FGFRs FRS2 GRB2 SHE PMC5991297__F1 AGE-RAGE signaling can activate ERK1/2 signaling HMGB1 NFAT5 TNF S100B JUN PMC9669388__F2 Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms NUMB GPX4 KEAP1 HEL-S-28 SMAD2 GSK3B TNF GSDMD NLRP3 TLR4 HEL-S-11 IL33 NOTCH1 SIRT1 BAX PMC2528845__F4 Opposing signals regulate sex determination in the bipotential gonad WNT4 FGFR2 SOX9 FGF9 SRY PMC8046021__F1 Heparanase triggers multiple pathways that drive myeloma progression HGF CXCL10 PIR HPSE IRS1 PMC7720107__F5 TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation GSK3B MYD88 ARG1 PMC2891025__F6 Deep mRNA Sequencing for In Vivo Functional Analysis of Cardiac Transcriptional Regulators: Application to GAq CORO2B NPPA EGFR NPPB ACTA1 LAMB2 RCAN1 MYOM2 HEL55 ANKRD1 NFATC2 PRMT2 CKAP4 HEL114 NRAP CASQ2 BTG2 MEF2C ABRA PMC7000407__F2 Circadian rhythm in intervertebral disc degeneration: an autophagy connection TSC2 ULK1 ATG12 ATG3 ATF4 EIF2A MTOR DKFZp686F0183 PMC8692627__F6 Representative mechanisms of tsRNAs in malignancies AGO2 FZD3 DICER1 NCL RUNX1 YBX1 JAG2 MAP3K7 HIF1A LATS2 SFMBT1 PMC8572706__F4 Therapeutic effects of Bombyx mori sericin on rat skin psoriasis through modulated epidermal immunity and attenuated cell proliferation NPB AHR RORA JUN LAT PMC5633085__F6 Tumor-induced osteomalacia FGF23 FGFR1 MTOR PMC6997863__F1 Different pathomechanisms linking DM and AD APP APOE PMC7442608__F4 Folate cycle is coupled to the methionine cycle through distinct mechanisms MTHFD2L SLC1A4 PSAT1 PSPH HEL-S-51e PHGDH PMC3957735__F2 Short-patch base excision repair pathway PARP1 UNG PCNA PMC7318773__F3 Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers IL10 TBK1 NRF STAT2 HIVEP2 TRAF3 TRAF6 IRF3 BCL2L1 NCR3LG1 BNIPL MAP3K7IP1 BCL2L14 STAT1 NLK CXCL16 TRIM52 NKIRAS1 CXCL17 RNF128 TRAF2 BAX PMC7761452__F2 Metazoan MOB proteins present extensive regulation between isotypes PLK1 DOCK6 DOCK8 FERMT2 LATS1 LATS2 CRLF3 DOCK7 PMC3767399__F4 The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp FECH UROD UROS CPO PMC6290938__F10 Proposed mechanisms by which Adam8 deficiency in leukocytes and/or lung parenchymal cells leads to exaggerated cigarette smoke (CS)-induced chronic obstructive pulmonary disease in mice ADAM8 EGFR IL1B PMC9122509__F6 Prostate cancer pathway BAD PLAT CDK2 ERG CDKN1B CYC1 BCL2 PTEN TF TMPRSS2 PMC7926735__F1 Transforming growth factor B (TGFB) signaling regulation by actin remodeling induced by extracellular matrix (ECM) stiffness SMAD2 SMAD4 LEMD3 mkl1 PMC10537408__F8 miRNAs in the HSV-2 infection of macrophages IL10 GRB2 TYK2 JAK1 SOS1 MTOR BAX PMC3153113__F7 Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth ELF2 TSC2 TSC1 EEF2 EIF2A RPS6 MTOR RHEB PMC7441816__F2 PVAT regulates VSMC dilation and contraction EFS PMC11103502__F9 Pharmacological activation of the HIF pathway improves the ischemic tolerance of brain-resident cells by reprogramming of glucose metabolism HEL-S-162eP PMC3687869__F2 Phosphatidylinositol-3-kinase/Akt signaling pathway BAD PTEN PMC11788444__F5 Crosstalk between dysregulation of metal ions and pathological proteins in neurodegenerative diseases HTT CDK5 APP SP1 PMC11788444__F4 Iron dysregulation in the lysosome and mitochondria of PD MFN1 MFN2 TFEB FTMT TF CP PMC3134295__F1 Apoptotic Process APAF1 FADD BAX PMC5127716__F4 Immune signaling cascades triggered by Cryptococcus neoformans recognition NLRP3 CARD9 IL16 BCL10 SYK PLCG2 IL1B PMC6668592__F2A GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer HEL-S-90n HEL107 PMC7136162__F2 Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs HEL-S-62p TFPI TNF TF PMC6291828__F1 B cell receptor (BCR) signaling pathways PLCG2 PTEN MTOR CD79B CD79A BTK CARD11 BCL10 BCR BASH LYN SYK AXL CD19 PMC5366820__F2 PDK1 contributes to polarization of signaling downstream to PI3K during cell migration PLCG1 ARHA PMC4327875__F2 Accredited translational medicine centre: Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY ATM USF2 EGFR PMC5496032__F7 Mechanisms on EET-mediated signaling in response to cardiac hypertrophy and fibrosis IL16 TIMP1 ARHA PMC7883590__F2 Myd88- and TRIF-Dependent Toll Like-Receptor 4 Inflammatory Signaling TBK1 CD14 IRAK2 TRAF3 TRAF6 IRF3 TNF MAP3K7IP1 COX2 TLR4 LBP IL1B MAL PMC99013__F3 Signal transduction cascades regulating pseudohyphal differentiation in S CDC42 PMC6158335__F2 Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection HP CFTR PMC4650980__F1 Receptor tyrosine kinases and their targeted therapies in gastroesophageal cancers: EGFR, VEGFR and MET EGF HGF EGFR PMC6889937__F5 Proposed action pathway through which Hnk protects cardio-myocytes against Dox-induced senescence NLRP3 TXNIP IL1B PMC6189490__F1 Salvage and de novo synthesis pathways for UTP synthesis UPRT OMP UMPS PMC5357492__F1 Interactions of the AKT signaling pathway with the GSK3B signaling pathways APC PDK2 GSK3B PTEN PMC6395781__F1 Mammalian O-mannosyl glycans: Biochemistry and glycopathology FKRP POMGNT2 POMK B3GALNT2 POMT1 POMT2 B4GAT1 PMC5852959__F6 CDK5RAP3 - AKT - GSK3B - Beta-catenin pathway in gastric cancer LEF1 GSK3B CDK5RAP3 PMC5545849__F1 TGFB signaling pathway TGFBR1 ARHA CDC42 PMC2942073__F1 Genetics of Psychosis in Alzheimer Disease: A Review SORL1 CHRNA7 NRG1 APOE PMC11395074__F4 Schematic representation highlights how miRNAs involved in the metastatic process through modulation of key molecular pathways such as TGFB, PI3K/AKT, Wnt/Beta-catenin, JNK/STAT, and Hippo/YAP, which are vital for cancer cell invasion and migration BRF2 ROCK1 SMAD2 CD82 NRG1 PTEN IL6 DKK2 CRKL SIK1 SOX4 NKD1 MAP3K2 ERBB2 KPNA2 NOTCH1 CTNND1 AXIN2 SP1 NCOR2 STAT3 PMC11395074__F3 miRNAs play a pivotal role in maintaining the delicate balance between cell survival and death by modulating the activity of key pathways such as PI3K/AKT/mTOR, MAPK, TGFB, Wnt/Beta-catenin, and JAK/STAT EGF HGF MAP3K2 ERBB2 APC JAK1 MTOR PBX3 PSD STAT3 PMC2752373__F1 Selected transformation pathways of tamoxifen and the main CYP enzymes involved CYP2B6 CYP2C9 CYP2C19 PMC5827395__F1 Evasion of the DNA-sensor-mediated IFN-I signal pathway by HSV-1 TBK1 CGAS DDX41 IRF3 PMC8508636__F1 RNA Modifications and Epigenetics in Modulation of Lung Cancer and Pulmonary Diseases YTHDF2 YTHDF1 ELF3 METTL3 FOXM1 EIF3A TIMP3 ALKBH5 MGA PMC5233495__F1 Canonical and non-canonical hippo pathway in ischemic heart disease NF2 LATS1 PMC5636945__F1 Linear modules for conversion of glucose TTN GRN HPR PMC3103528__F5 Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly BMP3 NODAL SMAD4 SKP1 ARHA THBS1 SP1 TNF ROR1 IFNG PMC6274944__F1 Schematic representation of the extracellular matrix (ECM) components implicated in the regulation of c-MET signaling EGF HGF EGFR PMC7276298__F8 MnTE-2-PyP prevents myofibroblast formation KEAP1 NQO1 PMC11620105__F7 Distribution of key targets in the PI3K/AKT signaling pathway BAD PTEN RAC1 EIF4E MTOR IRS1 RHEB TSC2 BCR MDM2 GRB2 SYK EIF4B RBL2 CD19 PMC2259386__F1 Prototypical myelin-derived neurite growth inhibitors, their receptors and intracellular signaling pathway EGFR RHO LINGO1 PMC6722227__F3 Immunopathology of Trichomoniasis (TV) TH HEL-S-62p SLPI PMC6021006__F6 Salidroside and liver fibrosis SMAD4 CSA2 PMC7509416__F5 p38 functions in neurological and psychiatric disorders HEL-S-44 TRPV1 PMC7593574__F2 Dab2 modulates inflammatory pathways in macrophages and dendritic cells CSF1R TLR4 SRC TRAF6 IRF3 IL6 CD80 MYD88 CSF1 IFNG PMC3110060__F1 MicroRegulators come of age in senescence HMGA2 IRAK1 CCND1 CDK4 BMI1 SIRT1 CDK6 CCNE2 PMC7509416__F1 P38 MAP kinase signaling pathway GSK3B ATF1 DLG4 PMC5748609__F3 ASFV entry and uncoating PAK1 CD63 EEA1 EGFR RAC1 PMC3030591__F4 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte FGF4 EGF PRKCZ PRKCE BRAF PPP3CA RASGRF2 ATF2 PPP3CC TGFBR1 PPP3R2 MYC TGFBR2 GCK CASP2 MAP2K6 CRKL TAOK2 DKFZp686L0365 MAF TNFSF6 ATF4 JUN IL1B MAPKAPK2 IL1A HSPB2 MOS FOS MAPK7 MAP2K2 TNF HRAS TMEM37 NLK IKBKB CASP3 PAK1 DUSP10 RAP1A PRKCH MEF2C PLA2G10 AKT3 PMC3365480__F1 Pro- and anti-inflammatory effects of heat and heat shock proteins CD14 HMGB1 TRAF6 IL1B PMC3030591__F7 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte CASP3 ATM CDK2 GEM PIGS PTEN ATR PMC7237311__F5 Brain proteins identified to be interacting with GFP-CASK through GFP-Trap mass spectrometry analysis are plotted using the STRING database interface RBBP4 TUBB6 GDA CASK HSPD1 COL11A2 SNTB2 POLA2 MAP1B LIN7C DISP2 DIRAS2 DLAT MAP6 UGGT1 ACR AIP APC SKP1 GAP43 CRMP1 PHGDH DKFZp761E1322 CDIPT ABAT ATP2A2 DUSP3 FAM171A2 PMC7060278__F4 KEGG maps analysis CDA RAD1 RHOD F2 FES VHL ARHA LPA RND1 PMC3182762__F1 TLR signaling pathways IRF7 TRAF6 IRAK4 TIRAP PMC7060278__F7 LPA metabolism, KLHL and KCNE3 as novel EMT controller genes KLHL14 PC PLD2 KCNE3 LPA LPP KCNB1 PMC8231117__F3 Irisin in Cancer Disease CDH2 MTOR STAT3 PMC4518442__F3 Possible effects of soy isoflavone genistein and tea polyphenolic compound EGCG on the Wnt pathway in breast cancer stem cells APC LRP5 CCND1 LRP6 PMC8231117__F2 Irisin in Cancer Disease CDH2 STAT3 PMC4440769__F11 TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation TRAF1 SHARPIN MAP3K7IP1 TRAF2 TAB3 PMC5833426__F7 Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization IL10 MRC1 ARG1 STAT3 PMC2820080__F5 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE ECE2 PLAT PC RARRES2 PSMD2 PHYHIP PMC2820080__F4 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE SPARC CCR2 SFN CDKN3 DST EGFL7 FOSL2 STAB1 PI3 CD109 PC SI LTBP2 GNG11 CXCL14 ADM GPNMB KRT14 NAMPT HEL70 MALL EHD2 ENG LMNA HEL-S-102 SBSN CSTA LIM2 CNFN NCCRP1 IGFBP4 HEL-S-93 SMC4 MGA TGFBI PMC11585160__F2 Smad5 Signal Path Diagram GIG8 RUNX2 MYC SMAD4 ID1 ID3 DKFZp781O1323 PMC7563548__F11 Partial of the NRF2-mediated Oxidative Stress Response pathway in Fayoumi birds with acute heat stress PIK3CD RASD2 ACTG2 DNAJA4 FOS GCLC DNAJB9 DNAJC10 POR UBB PS1TP5BP1 FGFR1 USP14 HEL-75 JUN PMC7612652__F8 Graphical summary EGFR SRC EIF4E PMC12040833__F10 Pathways (Beta-alanine metabolic pathway; monoterpenoid biosynthesis pathway; glutathione metabolic pathway) enriched by differentially expressed genes (DEGs)/differentially abundant metabolites (DAMs) LAP3 PMC11787465__F4 Intricate signaling pathways and functional networks of miR-23 in tumor cell biology NR1i1 KEAP1 RUNX2 PCDH17 PTEN CXCL12 CCL22 MSMO1 HIC1 GLS PMC11787465__F5 Functional roles of miR-23 in organ development SFRP4 RUNX2 PTEN HAS2 HMGN2 PMC7497309__F2 FOXO regulation by phosphorylation PAK1 CDK2 CDC2 PMC11809362__F3 Major function of RECK: (A) RECK is a metal protease negative regulatory factor: (a) RECK binds to MT1-MMP and binds it to the GEEC-CLIC endocytic pathway for degradation MMP2 RECK WNT7A ADAM10 ADAM17 PMC6714079__F4 Central carbon metabolism of T CIT MAL PMC11809362__F2 RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis RECK SP1 PMC7456147__F1 Human placental chorionic villus showing the different trophoblast subtypes: vCTB, STB, and EVTs in the maternal decidua, the latter arising from differentiation of vCTB through the cell column TEAD3 VGLL3 YAP1 VGLL1 TEAD4 TEAD2 PMC9589499__F1 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review KEAP1 GCLC SRC IL1B NQO1 BAX PMC9589499__F3 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review HMGB1 ATF4 APOC3 IL1B PMC7306093__F2 Schematic representation of Trp metabolism and its influence on Tregs AHR LAG3 FOXP3 PMC5371856__F1 Outer membrane protein-mediated pathogenesis EGFR B3GNT5 TNF PMC7806375__F7 Working model of this study GSK3B AKT3 PMC6961090__F1 Epidermal growth factor receptor pathway and mechanism of action of osimertinib EGF JAK1 MTOR TGFA STAT3 PMC5803867__F6 TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway NLRP3 ABCG2 PMC8220159__F2 Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications ULK1 BCL2 CD40 PMC9270875__F2 Metabolic Requirements for Pathogen Response HEL-S-133P HEL-S-281 GLS PMC8351524__F9 Apolipoprotein C‐II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway MMP2 GC MMP9 ENG PMC7598617__F4 IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis NLRP3 VIT NR1i1 IL6 MTOR STAT3 FOXP3 PMC11831194__F3 Neuroprotective role of OPN in Alzheimer's disease pathology SYK MYD88 PMC3543073__F2 Three examples of chromatin-modifying complexes and their mode of action MBD3 PRC1 SETDB1 BAHD1 HDAC2 MBD2 HDAC1 TF PMC9312354__F7 N6-Methyladenosine Methylome Profiling of Muscle and Adipose Tissues Reveals Methylase–mRNA Metabolic Regulatory Networks in Fat Deposition of Rex Rabbits Nbla10317 PTEN ADCY3 SNAP23 FOXO1 METTL14 YTHDC2 AQP7 MAP4K3 LPL PCK2 APMAP TNMD STAT3 PMC3543073__F4 Bacterial nucleomodulins targeting chromatin BAHD1 CYBB PMC5868510__F5 The molecular mechanism by which miR-134 aggravates atherogenesisMiR-134 downregulates ANGPTL4 expression by directly binding to the 3′UTR of ANGPTL4, leading to increased expression and activity of LPL ANGPTL4 LPL PMC9515028__F2 Possible role of long non-coding RNAs in recurrent miscarriage MXD1 IL18 ITGB3 SLC4A11 CDK2 CXCL8 EIF4E PMC4654680__F1 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer NOTCH2 SOX2 AREG BIRC5 VGLL4 SNAI2 SCRIB PARG LATS2 PATJ AMOTL2 NF2 TBX5 PMC11060011__F8 Molecular action schematic MFF METTL3 DKK3 TCF4 PMC4654680__F4 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer NF2 LATS1 LATS2 PMC4910294__F2 Differentially expressed proteins involved in the pathway of Alzheimer׳s disease CASP3 SNCA BAD GSK3B LPL CASP9 APP TNF FADD APOE PMC12164340__F6 Alpha-Linolenic Acid from Zanthoxylum Seed Powder Regulates Fatty Acid Metabolism and Influences Meat Quality of Pekin Duck via the ADIPOQ/AMPK/CPT‑1 Pathway LPL FABP5 CD36 PMC5808733__F7 Activation of the JAK-STAT pathway by viruses and the biogenesis, fission and fusion life cycle of mitochondria STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC8548342__F5 MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes PDC FLG SMO POR PMC3669661__F2 Phosphatidic Acid and Lipid Sensing by mTOR PC LPA HEL-S-5 PMC3669661__F1 Phosphatidic Acid and Lipid Sensing by mTOR TSC2 TSC1 PTEN MTOR RHEB PMC5204211__F1 The status of Nrf2-based therapeutics: current perspectives and future prospects MAF KEAP1 RBX1 BACH1 PMC3408695__F1 Part of the metabolic pathway of estradiol and the role of various enzymes involved: Estradiol is metabolized into 2-hydroxyestradiol (2-OHE2) and 4-hdroxyestradiol (4-OHE2) by CYP1A1 and CYP1B1 respectively CYP1B1 CYP1A1 NQO1 PMC2806519__F8 Prostaglandin F2Alpha-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium–calcineurin–NFAT pathway RCAN3 CXCL8 IL8RB RCAN1 PMC3369817__F8 Pathway diagram of the cyanobacterial core metabolic network CS CIT HEL107 RPE MAL HEL-S-162eP PMC7290734__F2 Type 2 immune response via ILC2s in asthma patients IL33 IL25 TSLP PMC6099186__F2 The role played by TCL1 in multiple signaling pathways TSC2 BTK TSC1 EP300 BCR ATM TP63 LYN SYK MTOR XBP1 PMC3777916__F3 Using Biological Pathway Data with Paxtools RPIA RPE PMC3777916__F2 Using Biological Pathway Data with Paxtools GNG2 GNB1 PMC3247963__F7 Model illustrating that early and late ISGs induction is regulated by multiple STAT1 posttranslational modifications TYK2 IFNAR2 IFNAR1 PMC5745837__F7 Molecular interactions in the Akt/mTOR signaling pathway.IP3K: Inositol-triphosphate 3-kinase; PDK: phosphoinositide-dependent kinase; TSC: tuberous sclerosis complex; Rheb: Ras homolog enriched in brain; mTOR: mammalian target of rapamycin TSC2 TSC1 MTOR RHEB PMC8708596__F4 An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT TSC2 TSC1 GRB2 PTEN RHEB PMC25571__F9 A model of cnxPg action TCF3 APC POP1 PMC9198215__F2 Sirtuins in Osteogenic Differentiation of Vascular Smooth Muscle Cells and Vascular Calcification ATM RUNX2 SIRT6 SIRT1 SIRT3 PMC3165779__F3 Cellular PA-interaction networks DYNC1H1 HSD17B12 MAP2K4 MYO1C ACACA EGFR AGK XPO7 HEL-S-101 COPA KDELR1 IPO11 EEF1G STAT1 SLC25A11 NUP93 RAB1B SLIRP PRKDC GBF1 FASN XPOT CIAO1 STOM TNPO1 PRPF6 DPM1 COPB2 AIMP2 KPNA2 TNPO3 CTNND1 MMS19 TNFAIP2 RAN TUBG2 PMC7839487__F1 Intermediate filaments cross talk with different signaling pathways SMAD2 APC MSC TGFBR1 GFAP SMAD4 PMC6288394__F1 Summary of the potential mechanisms of vaccine NSEs MTOR IL1B NOD2 PMC3764329__F2 Metabolic pathways for fatty acid and acetate utilization CS PMC10965438__F13 Nanomaterials modulating TAMs polarization for the treatment of pancreatic cancer TLR4 NPS CD163 BCL2 PMC6188698__F1 Regulation of Neurogenesis by DISC1 PDE4B DISC1 GSK3B FEZ1 AXIN2 NDEL1 PMC10965438__F15 Macrophage membrane-coated nanomaterials and macrophage-based microrobot for the treatment of digestive system tumor HMGB1 NPS EGFR MTOR PMC6190866__F6 Differentially regulated genes by IRF7 overexpression upon H6N2 infection ID4 POSTN IL11 APCDD1 FOXC2 CEBPB JDP2 RSPO1 ACVR2A FDPS INAFM2 SKI GRAP HLF PAPSS2 ADAMTS5 DAAM2 DKK3 DTX2 GFAP CHAC1 ID1 HTRA1 OSBPL7 NFATC2 PIM3 MAFK ALDH1A3 ATN1 PCDH18 RASA4 ADPRM APC2 MSMO1 RBM12 PMC5834288__F5 Myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway ENO3 FBP2 HEL-S-30 PHKA1 GSK3B MSTN GYS1 PFKM HEL-S-87p PYGM HEL-S-68p HEL-S-162eP PAK1 PHKB HEL-S-133P AGL HEL-S-281 PMC8168458__F1 Crosstalk between metabolic pathways and the tissues in which they are implicated in aging regulation NAMPT IGF1 PTEN CRTC1 IRS1 SIRT1 INSR PMC6642871__F2 The glycolytic switch in different cell types MTOR PMC7531435__F1 Key Figure TH RHO KIF21A PMC8301451__F1 Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer SMAD2 SMAD6 SMAD4 UNK TNF SMAD1 JUN DKFZp781O1323 PMC4975146__F3 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in cancer cell.Notes: The Ras-Erk pathway, PI3K/AKT pathway, and Src-signaling pathway have been demonstrated in this schematic picture SOCS2 SOCS3 GRB2 CCND1 SRC BCL2 PTEN SOCS1 PMC7585454__F3 Myocardial Phosphodiesterases and their Role in cGMP Regulation TSC2 GCA TSC1 PDE5A TRPC6 TRPC3 RGS2 PDE9A PMC4975146__F2 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in normal cell.Notes: Ras/Erk pathway directs to activate of the proliferation genes GRB2 MTOR PMC2666391__F2 Toll-Like Receptors and Corneal Innate Immunity TLR8 CD14 TLR5 LTA TLR7 TLR4 TLR9 IL6 MYD88 TLR3 PMC6058517__F1 Schematic representation of the rough PTX-PLGA-MS fabrication technique, tumor site injection and intracellular drug delivery pathway CCNB1 CCND1 PMC5624538__F1 Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis LCN2 CXCL2 CCL2 TNF PMC4077879__F1 Selective autophagy against membranous compartments TMEM59 ATG16L1 BNIP3L ATG14 RB1CC1 PMC1892626__F3 Regulation of hypoxia-inducible factor-1A (HIF-1A) and drug interventions currently in use CXCR4 EGFR VHL PTEN MTOR PMC11677460__F10 Hypothetical model SLC7A11 MSC PMC7734207__F2 Schematic diagram of the regulation of mitochondrial apoptosis, Wnt/Beta-catenin, JAK-STAT, and PI3K/AKT signaling pathways via different miRNAs in various human cancers BAD SOCS3 FOXM1 APC IFNGR2 FZD4 RHEB STAT1 TSC2 TSC1 APAF1 CCND1 FRAT1 IFNGR1 TCF4 STAT3 BAX PMC5520878__F8 Schematic diagram illustrating signaling of EZH2 and its upstream activator and its downstream effectors in GC CCND1 EZH2 SP1 PMC11814426__F1 miMOMP activates mtDNA-cGAS-STING pathway and promotes cellular senescence and tissue aging IL1A IL6 BAX PMC7963035__F1 NAD+ metabolism and its roles in cellular processes during ageing SIRT2 NAMPT NADK NMNAT3 SIRT3 SLC36A4 SLC12A8 SLC7A5 NAPRT SIRT7 SLC22A13 SLC25A51 HEL-S-90n SLC5A8 NMNAT1 KYNU SIRT4 SIRT5 SIRT6 NMNAT2 SARM1 SIRT1 PMC2711774__F2 Proposed biosynthetic pathway for the disorazoles ACP2 ACP3 CP HEL-S-5 PMC2888641__F1 Targeting Hedgehog - a Cancer Stem Cell Pathway PTCH1 GLI3 SMO PMC7880682__F6 Effect of curcumin mediated by PPARa in mouse liver C6 NR1C1 PMC6858476__F1 Schematic overview of steroidogenesis and corresponding urine steroid metabolites PAPSS2 EPO HSD11B2 SULT2A1 HSD11B1 CYP11A1 HSD17B2 POR CYP21A2 HSD3B2 HSD17B3 CYP17A1 STAR CYP11B2 PMC3411916__F3 [LM5]Strategies for treatment of traumatic central nervous system (CNS) injuries TSC2 TSC1 SOCS3 PTEN MTOR PMC4852799__F1 Appropriate activation and feedback control of TP53 activity is critical to effective tumor suppression ATM ATR RFWD2 PMC11506335__F3 Comparison of ATR activation and signaling pathway in interphase and in mitosis WEE1 TOPBP1 ATRIP ETAA1 CDC2 ATR PMC10215119__F1 Mechanisms involved in the regulation of macrophage polarization by exosomal ncRNA in AS HMGA2 IGF2BP1 ABCG1 KLF4 PTEN ABCA1 KLF6 BMP4 STAT3 PMC9231089__F15 Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis EGF PGP EGFR SRC STAT3 PMC8097443__F7 Ethylzingerone, a Novel Compound with Antifungal Activity ENO1 ENO2 EN2 tal-1 PMC3787764__F8 Proposed molecular pathway governing multiciliogenesis MYB MCC FOXJ1 PMC9312280__F4 Evaluation of Proanthocyanidins from Kiwi Leaves (Actinidia chinensis) against Caco-2 Cells Oxidative Stress through Nrf2-ARE Signaling Pathway MAF KEAP1 BAX PMC5731897__F3 Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study NAMPT PLAUR BRAF HEL2 CYP1B1 APLN PTGS2 XPC NRG1 PTEN LPAR1 HAS2 MMP3 FBLN5 MAX FHL2 CTNND1 CD40 MAPK1 PRKCH ADM INHBA STAT3 PMC6028781__F4 Central carbon and nitrogen metabolism of Arabidopsis thaliana active in most growth stages and conditions simulated GIP CIT CP MAL PMC4925073__F1 Pathway of codeine metabolism in a CYP2D6 extensive metabolizer UGT2B7 UGT1A1 PMC7531435__F3 Integrins Control Vesicular Trafficking; New Tricks for Old Dogs NUMB ARHA PMC8254040__F1 Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection NUP205 POM121 NUP214 NUP188 NUP160 TPR NUP62 NUP153 NUP58 NUP93 RAE1 NUP133 NUP54 NUP85 NUP98 NUP35 RAN NDC1 NUP107 NUP88 NXT1 NUP155 PMC3492658__F1 NOD1 and NOD2 signaling pathways and interaction partners NLRP3 CARD9 NOD1 ATG12 DAP IRF3 RIPK2 DKFZp686F0183 IL1B NOD2 MAVS PMC4846800__F2 Resistance mechanisms in MAPK-inhibitor treated melanoma NF1 BCL2A1 BRAF CDK2 CDK4 PMC4379579__F9 Fate of plasmids and their expressed antigens after electroporation (A); The Fas/FasL signaling pathway and some of the key molecules involved (B) APC FADD PMC4258820__F1 Representative ARG biosynthesis routes in prokaryotes AGA CIT PMC3260860__F6 Scheme of the EGR-1/GGPPS/ERK 1/2 pathway EGR1 GRB2 PMC7593815__F2 Illustration of the cellular context and key processes in which MPEG1 is implicated MYD88 TNF IFNG PMC11653477__F1 Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy IGF1 KEAP1 BDNF SIRT1 PMC3021368__F5 Foxo3 controls DCs functions FOXO3A BCL2 CTLA4 PMC8661833__F2 Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity GPC4 IMPACT SELP GLA TLR3 RAX2 PMC3943226__F1 Apoptosis signaling pathway ROCK1 BCL2 CAD TNF DIABLO BIRC6 BAX PMC10478613__F2 Structure and function of kartogenin RUNX1 RUNX2 BMP7 DKFZp781O1323 CBFB PMC8732860__F7 Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation NLRP3 HMGB1 GSDMD PMC6769940__F1 Interference of hepatitis C virus (HCV) with the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)/ Keap1-signaling pathway MAF IGF1R IGF1 KEAP1 ERO1A MTOR IRS1 CYP2E1 PMC6613992__F1 Endogenous oxalate synthesis pathway in hepatocytes GLO1 DAO PMC4762423__F1 Metabolism reprogramming in PDAC ME1 MYC RPIA RPE HEL-S-133P GFPT1 PMC8739690__F5 Transcriptomics analysis reveals the signal transduction mechanism of brassinolides in tea leaves and its regulation on the growth and development of Camellia sinensis IWS1 BAK1 BIN2 ELF4 PMC5784953__F7 Critical comparison of topology-based pathway analysis methods PLCG1 EGF BAD BRAF SOS2 ALK EGFR RXRG PLCG2 HRAS PDPK1 RXRA PRKCA RXRB RARB PRKCB RASSF1 ERBB2 STK4 GRB2 PIK3CA SOS1 TGFA ARAF PMC9302576__F1 Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment STAT1 TLR4 IRAK2 STAT3 PMC4130202__F2 New molecules targeting angiogenesis and crosstalks between angiogenesis and tumor microenvironment PIGF VEGFA VEGFB PMC309687__F10 Postsenescence survival in telomerase-deficient (tlc1Δ) budding yeast cells is controlled by three distinct Rad52-based homologous recombination pathways CIB2 RAD50 RAD52 RAD51 PMC1782192__F2 Direct and indirect activation of human natural killer (NK) cells TLR7 TLR3 PMC3854201__F4 Biological interaction networking of PSME1 and RPS12 in chronic atrophic gastritis (CAG) ChAT IKBKE BRAF NPPC ENG TNF HLA-B F5 MIA CCND1 RAF1 RPS6 IL1B RPS12 PMC4675703__F1 Therapeutic control of complement activation at the level of the central component C3 HEL-S-62p CS PMC5193490__F2 Nrf2 affects mitochondrial function at multiple levels ME1 HEL-S-26 PMC9160246__F3 Neuroinflammation in PD CX3CL1 IL6 TNF IL1B PMC6928941__F2 Ca2+ is mostly involved in mTOR-independent autophagy induction VIT LRRK2 TFEB HEL-S-11 AMBRA1 MTOR ATG14 PMC6166529__F1 Cancer Genome Atlas of glioblastoma multiforme NF1 PDGFRA DKFZp781B1423 CDKN2C ERBB2 EGFR MDM2 CDK4 PTEN RB1 CDK6 CCND2 PMC7405025__F2 Pathogenesis and management of myocardial injury in coronavirus disease 2019 CCL2 TNF ACE2 TMPRSS2 PMC9160246__F9 Mechanistic view of roles of different K+-channels in the diagnosis and treatment of the PD pathogenesis GDNF POR JUN PMC3368264__F1 An overview of the folate metabolism pathway in formation of essential intermediates in Leishmania DHFR FTL PMC11013124__F1 Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches NLRP3 MTOR PMC7699002__F1 Sulfur Metabolism Under Stress CTH MTR FES HEL-75 PMC9650603__F2 FOXK2 transcription factor and its roles in tumorigenesis (Review) FOS BARD1 HDAC2 SIN3A JUN FOXK2 SAP30 TET1 BAP1 PMC10760828__F9 Schematic representation of overall outcome of the study PML SP100 PMC8001769__F2 Schematic view of controlling cancer hallmarks and associated signaling pathway by lncRNAs IGF1R ATM MTOR PMC6497095__F9 Schematic view of signaling events elicited by LPS in RPE cells PC PLD2 RPE PMC5006627__F1 Interaction between the canonical WNT signaling pathway and other signaling pathways implicated in MPNST tumorigenesis LEF1 BIRC5 APC CXCR4 GSK3B MYC LRP5 CCND1 LRP6 TNKS PTEN PMC11351389__F3 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review MSC GSK3B LRP5 LRP6 AXIN2 PMC11641583__F2 YAP activation in KCs MOB2 AREG EGFR TEAD4 LATS1 LATS2 THY1 ARID1A TEAD2 TEAD3 PKP1 DSG1 NF2 ANXA2 PKP4 KLF4 DSG3 SRC KRT5 KRT14 PMC4344549__F1 Canonical Wnt signaling APC LRP6 DKK1 PMC4440880__F1 Activation and targeting of prosurvival pathways mediating FLT3 resistance PIM1 CXCR4 CXCL12 FLT3 MTOR PMC9459503__F6 Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer ACLY MLL2 FASN PMC11351389__F2 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review FGF23 RUNX2 SP7 BGLAP PMC5343023__F3 Fatty acid (FA) and cholesterol sensing in T cell immune responses FOXP3 PMC9236130__F1 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer RHO LPA PMC8762220__F2 Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer TWIST1 STOM MSC BMP4 PMC9005057__F1 SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides UMPS CLU PNP PMC2918880__F1 Schematic depiction of selected core elements of the unfolded protein response (UPR), featuring the components measured herein (; ; ; ) EIF2A BCL2 XBP1 PMC5528145__F2 Mechanistic association of insulin signaling with mitochondrial function in normal and diabetic brain GSK3B GSK3A BDNF SIRT1 PMC3021368__F2 PI3K in immune system BCR ICOS CD19 PMC8966389__F3 Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved TBK1 STAT1 STAT2 IRF9 CCNB1 IRF3 TYK2 IFNAR2 CDC2 JAK1 IFNAR1 MAVS PMC11641583__F3 YAP and TAZ interactions with signalling pathways and TFs SNAI1 WNT16 AREG SMAD2 CTCF EGFR VGLL4 GSK3B SNAI2 SMAD4 LRP6 DLL3 FUS FGFR2 P2RY6 KLF4 SRC SHH TGFBR3 AXL SMAD1 DKFZp781O1323 BRD4 PMC9236130__F2 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer HGF SRC LPAR2 TRIP6 LPA HIF1A MTOR LPAR1 LPAR3 STAT3 PMC5585656__F1 Proposed role of molecular and small molecule chaperones in proteostasis HEL-S-89n HEL-S-72p PMC9159919__F7 Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/Beta-Catenin Signaling Pathway CXCL1 dik APC SOST PMC9340220__F1 Antioxidants in Human Milk on Bronchopulmonary Dysplasia Prevention and Treatment: A Review SENP1 TXN SIRT1 NQO1 PMC5519008__F2 lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites ME1 HAO1 PIG59 ME2 CS HEL-S-11 ADA CIT TNLG7C MAL PMC3116598__F1 p21-activated kinases in Erbb2-positive breast cancer ERBB2 MYC MTOR PMC3467778__F3 Skewed Th17/Treg cell differentiation in patients with BD, a hypothesis RORC SMAD2 STAT3 FOXP3 PMC2992967__F2 Sonic hedgehog (SHH) pathway BAMBI SUFU PTCH1 GLI3 MYC SHH IGFBP2 SFRP1 SMO HES1 PMC5894198__F8 Schematic diagram of GDF15 activating the PI3K/AKT and MAPK pathway in cervical cancer progression GDF15 ERBB2 CDK2 MYC CCND1 CDK4 CCNE1 PMC8304001__F1 Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice STS SULT2A1 CYP11A1 CYP17A1 PMC10869801__F0 Macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation HMGB1 TSC1 TLR4 KEAP1 TRAF6 PMC6052671__F1 TGFB1 signaling cascade leading to EMT SMAD2 SMAD4 CDH2 CFTR PMC2849646__F3 Frequent amplification and overexpression of multiple EGFR-family-signaling components in non-small cell lung cancer (NSCLC) EGFR CDK5 GRB2 SHC1 PMC11609662__F8 Metabolic pathway map of detected metabolites OMP HEL-S-5 PMC6044387__F5 The two co-occurring pathways in PDAC that are predicted to drive oncogenesis based on the mutational landscape representing two common driver pathways PIK3R1 BRAF DKFZp781B1423 MYC PTEN RB1 MTOR CDKN2A RPTOR CDK6 CCND2 PI3 ERBB4 ATM MDM2 PRG4 CASP8 SET FOXO3A PDGFRA FOS ERBB3 BRCA1 TSC2 TSC1 EP300 CDKN2B PIK3CA BCL2 PHF24 PMC6044387__F6 MAPK heat diffusion sub-network: pathway extracted from the TieDIE subnetwork using heat diffusion analysis from the MAPK1 network node EGF HDAC3 ATF2 EGFR MAPK14 MAP2K6 BTK MAPK1 JUN CD19 MAPKAPK2 MAP3K1 FOS NTRK1 RPS6KA5 ATF3 MAP2K2 CBL NFKBIA SH3GL2 RPS6KA1 NFKB1 IL2RG RELA GRB2 JAK3 SOS1 SHC1 AGAP2 PMC5079184__F3 IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction GRB2 IL15RA JAK3 STAT3 PMC8388923__F7 Nepetoidin B from Salvia plebeia R. Br. Inhibits Inflammation by Modulating the NFKB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells KEAP1 TNF PMC10618387__F5 Crosstalk between the signaling pathway of pyroptosis, apoptosis, and autophagy NLRP3 SESN2 MTOR GSDMD PMC8515020__F1 Hyperinflammatory Immune Response and COVID-19: A Double Edged Sword TH NLRP3 HMGB1 TLR4 CCL7 CCL5 CCL2 TLR3 GSDMD IFNG CCL3 PMC3317017__F4 Altered signaling pathways and inhibitors APC EGFR SHH SMO PTEN PMC8637543__F2 Zinc Finger Proteins in Neuro-Related Diseases Progression KLF2 MZF1 CLDND1 PMC10618387__F3 Apoptosis is mediated by intrinsic and extrinsic pathways BAD TRADD CYLD FADD GSDMD PMC2665727__F5 Ty retrotransposition cycle DBR1 LSM5 DCP2 LSM7 LSM6 RAD52 XRN1 LSM4 LSM2 LSM1 LSM3 PMC8194305__F4 Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions TRADD TRAF6 IL1R1 IRAK4 MYD88 IL17RC STAT1 STAT4 TYK2 JAK3 JAK1 TRAF2 MLKL STAT3 PMC6823372__F3 KEGG pathways involved in the lipid methabolism of zebrafish enriched after MPs exposure PRND DAP PMC6322225__F2 Health to disease (HTD) network PTK6 TNF NPAS2 LAT PMC6834863__F2 The different apelinergic signaling pathways KDR F3 VEGFA ACE2 HEL-S-104 SIRT3 PMC4594611__F1 Hypothetical Model for the Transduction of Synaptic Stimuli to Long-Term Plasticity PARP1 MTOR POLI PMC4409285__F1 Schematic intracellular network required for lipid metabolism, Apo B biogenesis, and CM assembly in the enterocyte APOB TG ACAT2 PMC8745771__F3 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair PLK1 WEE1 CDC2 PMC6268691__F1 Biosynthesis pathway for gangliosides GAL GATC ST8SIA1 B3GALT4 PMC7483331__F2 Protein signaling networks regulating autophagy ATG12 CD63 SRC ATG101 STAT3 PMC1555658__F2 Cholesterol precursors and facial clefting SHH SMO PMC2922518__F1 Schematic illustration depicting the cellular pathways that lead to eIF4E activation and phosphorylation by Mnk1/2 MMP3 TSC2 TSC1 ELF3 MMP9 CCL7 PTEN CCL2 EIF4E MCL1 RHEB PMC4211376__F7 DAPK2 is a novel modulator of TRAIL-induced apoptosis DAPK2 APAF1 DIABLO FADD BAX PMC8745771__F1 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair CDC20 PLK1 APC CDC2 PMC5709754__F1 CD30 mediates its effects through a number of diverse signaling pathways, which in concert confer a survival benefit to the cells on which CD30 is upregulated TRAF1 JUNB TRAF2 PMC8534091__F1 Intersection of Purine and Mitochondrial Metabolism in Cancer GOT2 ADSL PAICS APRT MTHFD1 PMC6877939__F1 Overview of PI3K/AKT/mTOR signaling pathway and downstream effects PI3 EGFR PTEN PMC6918475__F1 Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs GCA CYP8B1 CYP7A1 PMC3403084__F5 Necrosis signaling pathways TRADD CYLD TNF TRAF2 FADD MLKL PMC9331965__F1 IRIDA Phenotype in TMPRSS6 Monoallelic-Affected Patients: Toward a Better Understanding of the Pathophysiology ERFE BMP6 SMAD4 HFE IL6 TF PS1TP5BP1 TFR2 STAT3 PMC5393505__F3 Network of damaging mutations in ACC associates to the TP53 pathway RHOBTB1 NF2 SIX1 TERF1 EPHB6 PMC2808316__F5 Metabolic model for Aspergillus niger INA MAL PMC5715147__F1 Schematic of albumin/AlbiVax nanocomplexes for efficient vaccine delivery and combination cancer immunotherapy APC HEL-S-92n PMC10528955__F1 Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer’s disease, and Depression TLR4 TG IL1B PMC11083345__F5 DEGs and DEPs involved in Alpha-linolenic acid metabolism, terpenoid biosynthesis and phenylalanine metabolism pathway PMVK MVD MAX PMC5997167__F3 Gene networks involved in the analyses of males with HCB exposure ACD GLA PCGF2 PMC3065826__F1 Metabolism, Cell Surface Organization, and Disease EGFR MGAT5 GAL MGAT1 MGAT2 PMC5997167__F5 Networks involved in the analyses involving males with nPFOS exposure FAM133B TAF1 REPS2 GRAMD4 UBL3 RB1 GAP43 NAA25 FGF20 CCNB3 ERMN CD2 BRD2 TSKS PMC3546058__F1 DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the omega-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways CFB CFH APP ABCA1 PPARG NR1C1 PMC8836889__F1 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review ATM APAF1 MDM2 BCL2 MCL1 BAX PMC2517789__F2 Two pathways from gp130 to hypertrophic gene expression STAT1 LIF STAT3 PMC2517789__F1 Cytokines and their receptors in cardiovascular diseases CNTF LIF CNTFR OSM OSMR PMC8807626__F3 Context-dependent modulation of TGFB pathway by LRG1 SMAD2 SMAD4 SMAD1 HMFT1766 DKFZp781O1323 PMC8745569__F1 Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research CRYM TRO MTOR PMC8836889__F5 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review BCL2 PTEN BAX PMC8836889__F3 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review GSK3B BCL2 MTOR PMC8836889__F2 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review FADD PMC7925333__F3 Major intestinal host defense pathways identified in C. elegans ATF7 TFEB FOXO3A ATF5 HIF1A XBP1 PMC3116140__F2 The core pathway of Notch signaling HES5 NUMB RBPJ HES1 PMC5893262__F3 TCR complex activation FOS GRB2 TNF LAT PMC3542954__F1 Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosisEBV infection disrupts normal cell death and survival pathways in various human tumor cells, including lymphocytes, fibroblasts, and epithelial cells BCR BCL2 CD74 IFNG PMC4670612__F10 Ingenuity Pathway Analysis of the subset of day-one genes that differentiate long-term success or failure, divided into two groups (F and G) following an unsupervised cluster analysis DNAJC22 KLK14 NOL9 CWC27 GPR89B TBRG1 ARL17B MYC CFL2 DNAJB3 KCNN1 ZNF568 RB1 RHBDL3 TMEM184B CDKN2A SAMD4A SYNGR3 HEL55 DONSON FAM86B1 UBC AP1AR CMAS MATN1 DMBX1 F2 ADAM21 EIF4B ADK FAM111A MCM9 DKFZp667O1614 PGAP1 CYB5R1 ADRB2 SLC26A11 RAC1 TNF CPA4 GGT7 HEL-S-308 ZNF431 UTP15 PMC8147474__F3 Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis NR1i1 SMAD2 PMC9389749__F1 Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma MUC12 VEGFA BMI1 PMC9586778__F4 Network Pharmacology-Based Exploration on the Intervention of Qinghao Biejia Decoction on the Inflammation-Carcinoma Transformation Process of Chronic Liver Disease via MAPK and PI3k/AKT Pathway CREBBP EP300 LCK EGFR MAPK3 VEGFA APP PIK3CA SRC ARHA HRAS STAT3 PMC6363635__F1 Pathways to DHT synthesis (modified from Ref DHRS9 HSD17B1 HSD17B2 HSD17B3 RDH5 AKR1C2 CYP17A1 HSD17B6 PMC9370349__F1 Alleviating Effects of Black Soybean Peptide on Oxidative Stress Injury Induced by Lead in PC12 Cells via Keap1/Nrf2/TXNIP Signaling Pathway KEAP1 TXNIP PMC6621164__F9 Model of the function of CTTNBP2 at dendritic spines CTTNBP2 SRC RAC1 PMC8125491__F3 Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease SNCA LRRK2 PMC6131612__F1 PI3K/Akt signaling pathway in HI BCL2 PTEN MTOR BAX PMC5923353__F1 Lytic cycle proteins contribution to tumor initiation and tumor maintenance through enhanced survival, inflammation and immunomodulation COX2 IL16 CXCR4 CXCL12 IL1B PMC6147765__F3 Different modalities of cell death CASP3 GPX4 IL18 ATG12 ATG3 RHO ATG10 DKFZp686F0183 FADD PMC3247287__F8 Profiling Insulin Like Factor 3 (INSL3) Signaling in Human Osteoblasts PLCB3 SRC RXFP2 PMC5597216__F1 Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages EGR1 HAPLN1 IGF2 VEGFA LHX3 FSHB CGA LHB VIP PRL GHRH PRKCA LAMA1 POMC TRH IL2 NCOA1 GAL CP PMC3863956__F1 Using PainNetworks to reproduce the NGF-TrkA signalling pathway NGF SOST GRB2 HRAS SHC1 PMC6937654__F1 miRNAs regulate the HSC activation and schistosomiasis liver fibrosis through modulating TGFB/SMAD signaling pathway NR1i1 COL3A1 SMAD2 SMAD4 TGFB1 PMC10473946__F1 Impact of inhaled and intranasal corticosteroids on glucose metabolism and diabetes mellitus: A mini review ANGPTL4 GC IRS1 PMC7895386__F5 Wide range of metabolic adaptations to the acquisition of the Calvin cycle revealed by comparison of microbial genomes CIT TNLG7C HEL107 MAL PMC8145311__F7 Distinguishing Alzheimer’s Disease Patients and Biochemical Phenotype Analysis Using a Novel Serum Profiling Platform: Potential Involvement of the VWF/ADAMTS13 Axis BOC ATP1A1 CAPN3 CTCF ARHGEF2 TSHZ2 PARP4 CR1 POU4F3 POTEB EYA1 SNTB2 POTEB2 ADAMTS13 KHSRP ASCC1 CYLD YEATS2 LTBP2 ZNF592 VWF hEMMPRIN NAAA EGR1 RIF1 LTBP1 GRN GATAD2A HSPG2 LRP4 UPF2 ITGAX TNFAIP3 AGAP2 PMC8890945__F6 Inhibitory effect on melanogenesis via PKA/CREB/MITF axis by DPN MC1R PMC11885516__F2 Dual role of reactive astrocytes ROCK2 NOTCH1 IL1R1 ROR2 TNF HES1 PMC8876623__F1 mTOR Signaling and Potential Therapeutic Targeting in Meningioma TSC1 NF2 CD44 PTEN DEPTOR RHEB MLST8 PMC4646847__F4 Oligonucleotide discriminators of the TLR9-cholinergic links TLR9 ACHE BCHE PMC8111166__F2 Kynurenine pathway KYNU KMO AFMID PMC6021586__F5 Potential effects of miR-143 and miR-135a on signaling pathways IL13RA1 MUC5AC GATA3 PMC7879635__F9 Signaling pathways affected by exosomal miR-199a-3p/145-5p CD9 CD27 NGF CD63 CBL PMC8073974__F7 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling TGFBR1 KPG_010 LPA PMC8237754__F1 Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review SIRT1 FOXO1 HEL-S-162eP BRD4 PMC4754913__F3 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor metastasis ARHA CCL25 PMC8960601__F2 Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications PDC CXCR4 MSC CCL2 STAT3 PMC4318143__F8 A Dlg5-mediated bifurcation in Smo activity during Hh response KIF7 GPR161 GLI3 SMO DLG5 PMC5182003__F2 AKT signaling pathway map KIT BAD APC EGFR GSK3B MYC MDM2 CD44 CASP9 MTOR TGFA PMC2759144__F4 Model depicting the E2Fs-FA/BRCA axis in the control of cell fate FANCD2 FANCM FANCL FANCA FANCB BRCA1 FANCE FANCG FANCF PMC5574030__F1 An overview of central carbon metabolism CS CAD HEL-S-162eP PMC7817765__F1 Activation pattern of NF-KB pathway in lung cell lines infected with SARS-CoV-2 CD14 FOS MAPK14 IRAK4 RAC1 TLR3 IKBKB BIRC2 LTA MAP2K1 NFKB1 JUN AKT3 PMC11914309__F9 Differentially expressed genes in TNF Signaling Pathway (rno04668) using transcriptomic data at 168 h after TMT administration CHUK TRADD CYLD JUN FADD PMC11914309__F7 Differentially expressed genes in Chemokine Signaling Pathway (rno04062) using transcriptomic data at 168 h after TMT administration BAD MAP2K1 GRB2 CRKL PMC4754913__F2 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor chemoresistance PTEN MTOR PMC5796186__F1 Malignant pleural mesothelioma disease progression CD44 PORCN LATS1 CDKN2A LATS2 FAT4 SUFU NF2 PTCH1 GLI3 SMO DCAF1 BAP1 PMC8565650__F4 Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways TSC2 TSC1 PTEN IRS1 RHEB PMC10308129__F7 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes ACVR1 KLF10 PTEN HDAC1 INHBB PMC8583909__F1 Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer EGF EGFR MTOR STAT3 PMC6417506__F3 Chemical induction of proximity is sufficient for the regulation of diverse cellular processes TBP DDB1 CUL4A CRBN PMC10308129__F4 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes PRDM16 UCP1 SMAD2 KLF10 HEL-S-104 SMAD1 HDAC1 DKFZp781O1323 PMC4973703__F2 Main lipid classes and biochemical pathways involved in the production of TAG in developing seeds PC LPA PSD PMC5709591__F5 Interactome of negatively and positively changed genes comparing differentiated NIKS with differentiated NIKS16 cells MYB GAD2 CTSS SOCS3 MAPK3 ALB MAPK14 NFKBIZ SLPI NF1 TNFRSF4 MMP2 RNF20 TIMP3 CD163 IRF2 PARL GPNMB LOXL2 BHLHB2 KLF16 CSK MAPK7 VEGFA HRAS GAST CCNO TIMP1 TNFSF11 NFKB2 FDFT1 GRM3 BCL2 OPRK1 MERTK BDNF TGFB1 TGFBR2 INS RERG TFRC ASPN SFRS3 HSF1 BTK AHR IRF4 GNRH1 RORC KAT2B VHL IL24 PTH NR1C1 MAPK15 SPRY2 CDR2 IL23A SP3 SERPINB3 HHEX PMC10308129__F2 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes SIAH1 SMAD2 KLF10 JUN ITCH PMC6060409__F2 Innate immune response to RSV: Advances in our understanding of critical viral and host factors STAT1 TLR4 IRF9 MYD88 MAVS PMC3432348__F1 Pathways activating and inhibiting complement HEL-S-62p CD59 C9 C4B_2 C7 C6 CR1 PMC3899953__F6 A model for the role of ATP-mediated interaction between Rtg2 and Mks1 in ATP homeostasis HEL-S-26 MKS1 HEL60 PMC3263309__F1 Notch, Wnt, and Hedgehog signaling pathways regulate normal and stem cell fate MAML1 APC MYC CD44 SMO PMC6627707__F1 Biogenesis of extracellular vesicles (EVs) carrying micro RNAs (miRNAs) in viral infection CD9 CD63 CD81 PMC2949777__F5 JAK/STAT pathway in infected EPCs STAT1 STAT2 IRF9 PIAS1 JAK1 IFI35 IFI6 PMC6701977__F3 Adenocarcinoma genotypes encode for transformation via the Ras pathway supported by the calcium pathway and the integrator complex ITPR2 CDKN1A HLA-DQA1 CDKN1B MAPK14 HLA-DQB1 SOX5 PRIM2 RAD51AP1 TNF PMC7527139__F1 Summary of metabolic networks in iFermCell215 MCC CIT MAL PMC9205143__F2 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders NTRK3 CDH2 SOX4 PMC9205143__F4 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders CDK14 TMEM9B PMC8533303__F6 Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones MYC EIF4E MTOR PMC5191957__F2 Carcinogenic Effects of Oil Dispersants: a KEGG Pathway-based RNA-seq Study of Human Airway Epithelial Cells CHUK ITGA2B MYC LAMB3 TRAF6 BCL2L1 RB1 LAMA3 ITGA2 IKBKB NFKBIA ITGA6 RELA BIRC3 PIK3CA ITGAV REL LAMC1 TRAF4 COL4A2 PMC7313573__F1 Figures show the metabolism and role of biotin, cobalamin, and pyridoxine in various pathways TH DBH PMC8753429__F6 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway HMGB1 TLR4 MYD88 PMC9092887__F10 miR-23b-3p rescues cognition in Alzheimer’s disease by reducing tau phosphorylation and apoptosis via GSK-3B signaling pathways BACE1 GSK3B ADAM10 BAX PMC9503744__F1 Crosstalk between Ca2+ Signaling and Cancer Stemness: The Link to Cisplatin Resistance CASP3 MDM2 CASP9 ATR BAX PMC2745643__F1 Beta-catenin signaling and its regulation APC BCL9 PMC11551840__F6 Proposed modes of mechanism of action of AZD5582 in OSCC TRADD RNF31 TNF TRAF2 CASP8 FADD MLKL PMC2939005__F1 Two major insulin signaling pathways TH GRB2 INS PMC12114876__F2 Medicinal Chemistry Strategies in Targeting TGFBR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR) TGFBR1 TGFBR2 PMC6925247__F7 TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2Alpha-ATF4 pathway ATF4 EIF2A TIPRL NBR1 PMC2898064__F10 Views of predicted functional interactions TNFSF6 CD40 CRADD PMC3639655__F4 Schematic depiction of c-Myc functional interactions with other pathways (for full discussion, see section Induction–Reversion Tumorigenesis in Animal Models by Oncogene-Driven Cancer Network Formation) CDK2 MYC MDM2 CDK4 CDK6 PMC8026474__F2 Simplified overview of PRR signalling pathways in gastrointestinal epithelial cells TLR5 TLR9 NLRP1 NLRP6 TRAF6 MYD88 TLR1 ALPK1 NOD2 TLR3 IL16 TLR4 TIFA PMC5037548__F4 Apoptosis signaling pathways induced by icariin and icariside II TRADD FADD BAX PMC6677617__F4 Shh activates the PI3K/AKT and INSM1 signaling pathways to stabilize and prevent N-myc from entering the proteasomal degradation pathway ASCL1 GSK3B INSM1 SHH PMC8397734__F4 Sulfur energy metabolism and physiological interaction scheme of E. rectale and B. wadsworthia in the human gut SLA MUC2 DHPS PMC3533556__F7 IL-13–induced airway mucus production is attenuated by MAPK13 inhibition MAPK13 CLCA1 MUC5AC PMC5686390__F1 Mucosal-associated invariant T (MAIT) cell activation SAG APC MR1 LAG3 PMC2704469__F8 Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte PDGFRA APC OLIG1 OLIG2 TCF4 PMC8879721__F8 Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling CCND1 CDK4 CDH2 STAT3 PMC3233564__F3 Mammalian MAPK signaling pathways MAF MAX TRAF2 PMC6881749__F4 A proposed model of the impact of elevated levels of circulating IL-6 on skeletal muscle redox balance HDAC2 NQO1 PMC6431020__F5 Schematic diagram of molecular mechanisms underlying PA-induced GC metastasis FABP5 SP1 PMC3097097__F2 Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term CS IL17F TRAF6 CCL7 JAK1 SP1 IL17RC PMC10970955__F1 Systematic engineering for the de novo biosynthesis of genistein and glycosylated derivatives PGM2 ACD PMC9046764__F6 Genomic signatures of artificial selection in the Pacific oyster, Crassostrea gigas ITGB3 SMAD2 ATF2 EGFR NOTUM SMAD4 FZD4 FST BIRC2 MAP4K3 CASP9 CDK4 WNT2B DUSP3 CASP8 CDC42 PMC8642467__F4 Mutations that switch genes from two-hit to one-hit drivers in six cancer types BRAF KEAP1 SMAD2 NRAS SMAD4 PTEN MTOR TSC2 NF1 ATM MDM2 NOTCH1 STK11 PIK3CA PMC8123811__F3 On Iron Metabolism and Its Regulation BMP6 HAMP SMAD4 HFE SMAD1 DKFZp781O1323 TFR2 PMC8219471__F1 STING and liver disease CGAS IRF3 PMC9320502__F3 Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions MAF NLRP3 TRAF6 PMC2880289__F6 Complex deregulation of the Neuregulin/ERBB2 signaling pathway PRKCI PIK3R1 EREG BAD SOS2 HSP90AB1 CDKN1B MYC PTEN MTOR HRAS GRB7 RPS6KB1 ERBB4 MAP2K1 SI ERBB2 GRB2 RAF1 RPS6 PMC3494627__F3 Cancer-suppressive inflammation TRAF6 MYD88 IL1B PMC7463798__F3 Proposed signaling pathways affected by SphK inhibitors DES MTOR SPHK2 PMC3728269__F1 Signaling pathways in melanoma.Notes: Oncoprotein Ras activates both the MAPK and PI3K/Akt survival pathways BRAF STAT3 PMC4772274__F2 Ingenuity pathway analysis of miR-221 and miR-483 target genes HIPK2 MYC CRAT SHANK2 FMR1 CACNB4 DMRT3 ADAM11 STAT1 ATXN1 TIMP3 KSR1 CPEB3 ATE1 BTG2 KIT ZNF385A PAFAH1B1 ADCY1 FOS MAPK10 SPRED1 NRG1 EIF4E NFATC3 PPP3R1 PAIP2 GRB2 PBX3 FGF14 PMC3910500__F6 Canonical PI3K and MAPK pathway activation determined by reverse phase protein arrays and compared between GBM subclasses: Proneural (P, purple, n=55) and Mesenchymal (M, red, n=45) TSC2 TSC1 EIF4E IRS1 PMC3199248__F1 TLR induction of inflammation by parasitic infection IRF7 IRF3 MYD88 PMC8985231__F8 Intercellular Communication in the Islet of Langerhans in Health and Disease PDE3B EPHA7 SSTR2 EPHA4 PMC5749594__F3B Association of the activity of metagene 19 with two distinct image phenotypes EGF PI3 LRIG1 EGFR PMC9653095__F3 NAD+ synthesis from the de novo, Preiss-Handler and Salvage pathways NAPRT HEL-S-90n PMC5749594__F3A Association of the activity of metagene 19 with two distinct image phenotypes EGF PI3 LRIG1 EGFR PMC9653095__F6 Graphic summary representation of tryptophan metabolism and disposition in cancer biology and proposed therapeutic strategies SLC7A5 KYNU SLC3A2 PMC3521040__F2 Molecular mechanisms of activation, amplification, regulation, and evasion of the AP C3 convertase HEL-S-62p SCIN CD46 FH CD55 VCP CP PMC11800460__F7 Graphical abstract image illustrating the mechanism of EPN3-mediated EGFR stability and its role in NSCLC development EPN3 EGF EGFR PMC3695632__F3 Case 19-2010: A 35-Year-Old Man with Adenocarcinoma of the Cecum RICTOR BAD EGFR MYC MDM2 GRB2 CCND1 MCL1 MTOR PMC8144931__F5 Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells BAD FAR1 MEI1 PTEN RAC1 TSC2 BCR MDM2 SYK RAF1 GAL RBL2 CD19 PMC3891682__F2 Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment LIMK2 SEMA4F L1CAM EFNA1 ROCK1 EFNB2 PAK6 PAK4 EPHA7 RAC1 EPHB4 NTN1 SEMA5A SEMA6D EFNA5 GNAI3 PLXNA2 SEMA6A SEMA3D DCC PMC5606116__F2 Signaling pathways of IL-2 JAK3 MTOR PMC11837473__F1 Integrated stress response signaling pathway ELF2 ATF4 PMC11837473__F3 Integrated stress response in neurodegenerative disorders ATF4 TRIB3 HEL-S-44 IFNG PMC10884763__F3 Illustrative representation of molecular mechanisms of obesity-induced non-communicable diseases TSC2 TSC1 GRB2 PTEN PMC11837473__F2 Mitochondrial dysfunction and ISR: The activation of the integrated stress response (ISR) during mitochondrial dysfunction is triggered by various mechanisms DELE1 ATF4 OMA1 PMC8206782__F3 Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 Patients TLR8 TLR7 TLR4 IRF7 IRF3 MTOR ACE2 ZBP1 GSDMD IFNG PMC10884763__F5 WATME-specific immunotherapy for obesity-induced coronary heart disease (CHD) NLRP3 PCSK9 TLR4 IRF3 PMC12164274__F5 Mapping of transcriptomic data to the nonsmall cell lung cancer pathway RARA FHIT HGF POLK CASP9 DES JAK3 BAX PMC7476772__F2 Immune Response to SARS-CoV2 & pharmacodynamics of rheumatology medications COX1 APC IL2 STAT3 PMC4997642__F1 Canonical Wnt signaling pathway (reproduced with permission from) APC PMC9587158__F1 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD STMN2 IMP3 PMC6804710__F1 Canonical and non-canonical Wnt signalling pathways known or needed to be proven to participate in rat tooth germ development.,,,,,,,,,,,,,,,,,,,, ROCK2 BAMBI INVS APC SOST CER1 SMAD4 SKP1 ARHA RBX1 NLK DAAM1 SIAH1 PMC9569894__F8 Transcriptome Analysis Reveals the Complex Regulatory Pathway of Background Color in Juvenile Plectropomus leopardus Skin Color Variation SOST DCT TYRP1 MC1R IRS1 PMC3294429__F4 The NDT80 transcriptional induction pathway CDC2 PMC2804177__F9 The signaling pathways regulating osteoblast-like cells proliferation in response to OSS CDK2 CDK4 CDK6 PMC5658232__F1 PI3K/Akt/mTor pathway and effects of mTOR-inhibitors TSC2 TSC1 IRS1 PDPK1 RHEB PMC6335494__F7 Schematic model of intracellular signaling mechanisms regulating proteasome inhibitor-induced apoptosis by FLT3-ITD involving the STAT5/Pim axis and the mTORC1/eIF4F/Mcl-1 pathway MCL1 EIF4B BAX PMC4240309__F2 Smad-dependent and Smad-independent TGFB family signaling ALK TRAF6 ARHA MTOR CDC42 PMC7019324__F3 Pathways of macro-autophagy ULK1 ATG12 ATG3 ATG10 ATG14 DKFZp686F0183 PMC7019324__F2 Extrinsic and intrinsic apoptotic pathway OMP TRADD FADD PMC6077207__F8 Schematic presentation elucidating proposed mechanisms that TLB protects PC12 cells against oxidative stress-induced injury KEAP1 SIRT3 PMC5223235__F3 Processing and presentation of MHC class I and II restricted antigens for CD8+ and CD4+ T cell recognition, respectively APC B2M PMC7019324__F7 Routes of the complement system with its inhibitors currently studied in kidney transplantation C9 CS C4B_2 C7 C1S C4A PMC7019324__F6 Toll-like receptor 4 signalling TBK1 HMGB1 TLR4 IRAK1 TRAF6 IRF3 MYD88 TIRAP PMC11678759__F3 Signaling pathways of melatonin ME1 MAPK6 CAND2 PMC3470116__F6 Simplified schema of putative signaling pathways accountable for the differential responses of A549 (A) and SNB19 (B) cell lines to Hsp90 inhibition and IR MDM2 CDK4 PTEN CDC2 PMC3469673__F1 Activated CD47 is a proximate regulator of multiple cell survival and cell death pathways CD47 GC SRC BNIP3 PMC6454043__F1 Ceramide (Cer) synthesis pathways and their cellular compartmentalization VPS35 PINK1 SMPD4 TLR4 LRRK2 SMPD2 PLA2G6 MTOR CERK BAX PMC6969104__F9 MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer SOX2 PC MYC CDK4 EZH2 PMC9001082__F3 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress SMAD2 NOX4 MTOR PMC6318317__F1 Wnt signaling pathways and the intervention targets of Wnt pathway inhibitors APC GSK3B LRP5 LRP6 ARHA RHO PMC9001082__F4 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress AHR KEAP1 NOS2 MTOR PMC2748726__F1 Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas CDKN1A CD40 ATR CHEK1 IRF4 BPI BCL6 PMC12069271__F5 Pathway diagram of the NF signaling pathway (available at https://www CXCL1 SOCS3 TRADD FOS LIF TRAF3 CXCL3 IL6 TNF TNLG7C IL15 CASP3 CYLD TRAF2 FADD MLKL SELE PMC6484783__F2 Histone chaperoning pathway: from ribosome to nucleosome SETDB1 NASP TLK1 CDAN1 IPO9 TLK2 HAT1 PMC12069271__F4 Pathway diagram of lipid and atherosclerosis (available at https://www TH CD14 BAD TANK PROC TNF HDC NLRP3 APOB VLDLR TLR4 ATF4 CASP9 SELP SELE TIRAP STAT3 MAL PMC4166933__F1 Multiple leptin signaling pathways PDE3B SOCS3 GRB2 STAT3 PMC2675987__F1 Calmodulin-dependent nuclear import and disease RAN SOX9 SRY PMC10979123__F7 Schematic diagram illustrates the multifaceted role of the redox-sensitive GSK3B in podocyte injury upon type 2 diabetic insult and the protective effect of targeting GSK3B IL6 TNF IRS1 NQO1 PMC3731217__F7 Cited1 Deficiency Suppresses Intestinal Tumorigenesis CITED1 APC PMC4066587__F2 The stomatal signaling pathway BAK1 BIN2 ERF RFWD2 PMC7241242__F8 Metabolic pathway showing the reactions involved in drought stress response at day 13: Red and blue arrows represent active reactions in drought and control, respectively TCP1 CS CIT HPR PMC8413067__F1 The Wound Healing through Noncoding RNA Interplay and GSK-3B/NFKB Signaling Interaction IKBKB COX2 BCL10 AGER CXCR4 CXCL12 TNF PMC3564524__F10 Novel signaling pathways involved in apo(a)-mediated effects on vascular endothelial cells GSK3B SRC RHO PTEN CD36 PMC3005738__F1 Metabolic pathway of tamoxifen SULT1A1 CYP2B6 CYP2C9 CYP2C19 NAT1 PMC4398509__F1 Working model for pathway for bacterial lipoic acid metabolism and its possible regulation LIPA CRP PMC3606489__F3 TGFB/BMP and the Wnt pathway SMAD4 PMC6664756__F4 Predicted mechanisms of ELF1 regulation of doxorubicin-induced apoptosis TFIP11 TMEM86B ATM BAK1 BCL2 EIF4A3 IPO13 NABP2 PMC8607587__F1 Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages IGF1 DKK1 RPE PMC4526153__F4 The Biophysics and Cell Biology of Lipid Droplets DGAT1 PC DGAT2 LPA PMC11312736__F7 Glycolysis/gluconeogenesis, pentose phosphate pathway, photosynthesis and sucrose and starch metabolism in zygotic embryos of Yucatan green dwarf and Mexican Pacific tall cultivars PDC HEL-S-162eP PMC10835843__F8 Expression heat map of related genes and metabolites in phenylpropane biosynthesis, ascorbic acid, succinic acid and glutamic acid metabolic pathway CS MNT RP1 HEL-S-64p RP2 OGDH HK2 GLS PMC11312736__F8 Saturated and unsaturated fatty acid metabolic pathways and mevalonate and isoprenoid biosynthesis at intermediate and mature stages of YGD and MPT zygotic embryos MVD IDI1 MCAT HMGCR ACAT2 PMC11542157__F2 Signaling pathways regulating CMA activity TFEB GFAP MTOR PMC4850081__F23 Central Metabolism probed by hyperpolarized 13C enriched precursors FH DES MAL GLS PMC9258700__F4 Gynostemma pentaphyllum against non‐alcoholic fibre liver disease based on network pharmacology and molecular docking TSC2 BAD GRB2 INS RHEB PMC9097439__F2 Regulatory role of short-chain fatty acids in inflammatory bowel disease NLRP3 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC7904562__F5 Network of transcriptional NR1I3-mediated response elicited by pesticides (here shown: IMZ) in rat liver, as computed with Ingenuity Pathway Analysis software CYP2B6 EPHX1 GSTM5 APP CYP1A1 MED1 PMC11542157__F6 CMA dysfunction contributes to multiple diseases NLRP3 EGF PAX2 EGFR MCL1 PMC11542157__F5 CMA and neurodegenerative diseases NLRP3 TFEB MEF2D PMC4905058__F2 General overview of the class I PI3K signaling pathway TSC2 BTK BAD GAB2 ARHA RHEB PMC4655250__F2 Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment BRAF ATF4 ATF3 MC1R PTEN MTOR PMC8935059__F9 Mitochondria Related Cell Death Modalities and Disease IKBKB NFKBIA IKBKG NFKB1 RELA CA9 PMC8924541__F4 Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats BCL2 TNF TG PCNA PMC8811214__F2 Cross-Talk Between EGFR and E-Cadherin EGF EGR1 MMP2 MMP9 EGFR ARHA STAT3 PMC2911128__F1 PI3K/Akt/mTOR signaling pathway BAD MDM2 EIF4E MTOR DEPTOR RHEB PMC6895153__F5 Hormone-related pathways enriched in DEGs of the brain and gonads TPM1 TSHR PRLR GHR CYP11A1 FSHR LHCGR CYP17A1 STAR PRL PMC6406801__F6 Kinetochore PP2A-B56 and PP1 promote the stability of microtubule attachments and efficient Spindle Assembly Checkpoint silencing in animal cells NUF2 PLK1 KNTC2 SPC24 CDC2 KNL1 SPC25 PMC5356307__F7 Model describing the effect of a synergy between extracellular TGFB1 and Hsp90B on downstream signalling in colon cancer cells SMAD4 TGFB1 PMC3911027__F4 Metabolic potential of Acidilobus-like populations from YNP deduced from coding sequences obtained from metagenome assemblies PDC HBD POR FADD MAL PMC2384123__F8 Possible model for CCL5-mediated mRNA translation in CD4+ T cells CCR5 CCND1 CCL5 EIF4E MTOR EIF4B PMC3520613__F5 Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates PLA2G7 VLDLR PMC8242269__F10 Large-scale Proteomic and Phosphoproteomic Analyses of Maize Seedling Leaves During De-etiolation PC RPE HEL-S-162eP PMC11775980__F2 Lipid Pathways Located at MAM SPTLC1 ACAT1 SCD SPTLC2 PSD PBR STAR PMC8391210__F3 Follistatin-Like Proteins: Structure, Functions and Biomedical Importance SMAD2 TNF MTOR FOXO1 MVP PMC7602614__F3 STAT3 regulates the transcription of gene sets involved in cancer development SOX2 HGF TWIST1 VEGFA ABCC6 ABCC2 STAT3 PMC7602614__F2 JAK/STAT signaling drives the differentiation of T helper cells (Tregs) STAT1 STAT4 IL1B GATA3 STAT3 FOXP3 PMC5881442__F1 Mechanisms for visual chromophore production in the retina relevant to cone pigment regeneration RPE65 F2 RPE PMC3605242__F6 Ingenuity Pathway Analysis visualization of oncogene interactions TLR9 IRAK1 FLNA SMAD2 MYD88 RB1 TP53BP1 DCN SNCG SMARCA4 MDM2 RAD51 AXL HCLS1 ITGB3 PLAUR PLEC FOS CDKN1B ERBB3 DACH1 MAP3K5 SNAP23 BRCA1 MED14 TNFSF11 NEDD9 CXCR4 PPM1D GRB2 PPP2CA ATR TNFAIP3 HEL-S-72p CD36 PML IKBKG EGFR PPP2R1A PROX1 CSF2RB DBF4 ADAM17 CEBPB CDK7 INSR CHEK2 BTK HEL-S-67p MYO6 ATM CCND1 CDC2 YWHAG JUN IL2RB KAT2B KIT TLR5 PELI1 ITGB1 CBL CASP3 PTPRC PPP2R2B PELP1 ERBB2 LYN JAK3 JUND SHC1 FADD SP3 APPL1 STAT3 CD24 PMC9026097__F9 Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes MAF CXCL8 IL6 HMOX1 IRF-1 CASP4 PMC6962519__F3 Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)-independent regulation of protein translation TSC2 EEF2 MTOR DEPTOR RHEB PMC4051995__F2 Mammary Development and Breast Cancer: The Role of Stem Cells NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC11394644__F1 NAD+ biosynthesis pathways NAPRT HAAO NAMPT HEL-S-90n KY KYNU NNMT AFMID PMC11394644__F3 Summary reaction schemes depicting the influence NAD+ biosynthesis pathway reactions on the tumor microenvironment (TME) NAPRT NAMPT NMNAT2 NNMT PARP16 PMC11394644__F2 Reaction schemes for NAD+-consuming enzymes SIRT2 SIRT4 SIRT6 NNMT SIRT1 SIRT3 PMC6856900__F4 Gene expression profiles of the PI3K-AKT signaling pathway in treated HepG2 cell MYB HEL-S-1 MYC PRKAA1 BCL2L1 PRKCA TNFSF6 MDM2 PCK2 EIF4E HRAS IRS1 RHEB RXRA TSC2 TSC1 MTCP1 CDK2 GRB2 STK11 PPP2CA BCL2 CHUK BAD PHLPP2 CSF3 CSF3R PTEN BCL2L11 EIF4EBP1 MTOR LPAR1 RPTOR TLR4 ATF4 CCND1 MAGI1 EIF4B SGK1 RBL2 GYS1 RAC1 RPS8 ANGPT1 MAP2K1 NFKB1 PIK3CA CRTC2 RAF1 MCL1 SOS1 PMC12084782__F7 Graphical abstract of this work DCN SMAD2 SMAD4 PMC8989389__F1 Malignant glioma subset from actuate 1801: Phase I/II study of 9-ING-41, GSK-3B inhibitor, monotherapy or combined with chemotherapy for refractory malignancies GSK3B BCL2 PMC8940245__F3 Akt: A Potential Drug Target for Metabolic Syndrome BOC RAC1 TG IRS1 FOXO1 PMC11754404__F7 The effect of Formononetin (FMN) on porcine oocyte in vitro maturation and early embryo in vitro KEAP1 PTGS2 CD44 PTGS1 CCS PMC8597313__F2 New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis CASP3 INA PINK1 VAPB CGAS ND6 ND3 STMN2 NEFH OPTN PKN1 NEFL PMC10299206__F2 TGFB signaling pathway SMAD2 DROSHA SMAD6 SMAD4 RHO MTOR JUN TRAF4 PMC10299206__F3 Relationship between genes related to TGFB signaling pathway and pathogenesis of oral cancers RUNX3 SMAD2 MYC SMAD4 TRAF6 CDK4 ARG1 TXN TGFBI PMC3601079__F3 Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming CASP3 BAD FOS SMAD2 APC TGFBR1 GSK3B CASP9 SMAD4 DCC JUN BAX PMC5706558__F1 Strategy for analysis of ERBB2-driven gastric cancer SET ERBB2 EGFR MYC GRB2 PMC10384322__F2 Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis GPX4 TLR4 LPO ROS1 TF PMC5006950__F1 PD and PK pathways of HMGCo A reductase inhibitors (Statins) APOM HMGCR PMC5706558__F8 Summation of the proteomic values for the ERBB2− sample set for genes present in the regulation of actin cytoskeleton pathway for ERBB2− set from KEGG F2 APC INS DOCK1 RHO HEL114 PXN CR1L PMC2727866__F1 EGFR-dependent MAPK activation IGF1R EGFR HBEGF LPA PMC5706558__F7 ERBB signaling pathway analysis HEL-S-11 SHE TGFA PMC4733034__F2 Assay for defining the immunostimulatory potential of different RNAs IRF7 IRF9 IRF3 PMC9637655__F1 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology OGA XBP1 PMC5750051__F3 Proposed pathway for B12 targeting to methionine synthase for MeCbl synthesis MMACHC MMADHC PMC7600793__F6 Scheme of N9 microglia NF-kB, NFAT, MAPK, and IL-10/STAT3 inflammatory pathways modulated by 2J19 GIB fraction CD40 JAK1 STAT3 PMC3406917__F3 Schematic Diagram of Matrix Protein Import into Peroxisomes.Cytosolic PEX5 and PEX7 recognize their cargo proteins (square and round shapes) via binding of specific targeting sequences, PTS1 and PTS2, respectively PEX7 PEX6 PEX5 PMC9637655__F3 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology SMAD2 NOX4 REST MTOR OGG1 SNAP29 XBP1 ALDH2 CD36 PMC5112273__F2 How autism-risk genes regulate neuronal structure and their sites of action CTTNBP2 NCAM2 SHANK3 MYO16 STXBP5 PTEN MTOR SYNGAP1 DYRK1A ADNP DLGAP2 BDNF ELMO1 PMC5736463__F7 RUNX2-I is an early regulator of epithelial-mesenchymal cell transition in the chick embryo SNAI1 TWIST1 ZEB2 POSTN SNAI2 PMC5406241__F1 Schematic illustrating our strategy to generate iPSCs resistant to IL-1-mediated signaling for tissue engineering applications TRADD UNK MYD88 MAP3K7IP1 PMC3959765__F3 RANKL-perturbed network and master regulators MYC KLF10 MAPK14 TGFBR2 TRAF3 GATA6 TRAF6 HIF1A SOX9 HOXA13 POU2F1 MEN1 SRC CAV2 CDH2 SOX2 VCAN MAP3K7 VEGFA IL6 ITGB1 ID1 AURKA CBL FOXA2 WNT3 VEGFC TIMP1 MAX TWIST1 GAB2 NRP1 RELA FHL2 ENO2 MAP3K14 SYK HEL113 PPARG TGFB1 INHBA TCF4 CDC42 AKT3 PMC4189458__F2 Progesterone functions via intrinsic (mitochondria-centered) and extrinsic (cell membrane-mediated) pathway of apoptosis DIABLO FADD PMC4459083__F1 Scheme for producing fatty acid-derived biofuels in yeast PDC PAH PMC3475164__F1 Biosynthesis of glycerophospholipids PC PAH PSD PEMT HEL-S-5 PMC7798998__F2 Innate immune signaling pathways sensing SARS-CoV-2 TLR8 CGAS TLR7 MYD88 TLR3 MAVS PMC1564158__F2 Predicting Essential Components of Signal Transduction Networks: A Dynamic Model of Guard Cell Abscisic Acid Signaling PC HEL-S-84 GC RAC1 PMC2709272__F1 Wnt/Beta-catenin signaling in adipogenesis and metabolism GSK3B DKK1 TNF WNT5B WNT10B SFRP5 PMC7989008__F5 Re-analysis of 29 selected genes by KEGG pathway enrichment FES PIGS PTEN PRH2 CDK6 RFWD2 CASP3 PERP ATM CD2 APP CASP9 ATR SIVA1 PMC10377129__F9 Active Estrogen–Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells ALAS1 SLC25A38 NCOA1 SDHB PMC9500712__F8 Molecular Mechanisms of Cassia fistula against Epithelial Ovarian Cancer Using Network Pharmacology and Molecular Docking Approaches F10 MPO F2R NR3A2 PGR ALB TOP2A CCR1 INSR MMP3 IL18 KDR MMP2 STS PTPN11 CDC2 CYP17A1 ABCB1 NR1H2 KIT PRSS1 FBP1 PTGS2 MMP9 SHE CA9 TNF AURKA PDC CDK2 RELA TYMS PIK3CA BCL2 ACLY TERT PMC7258299__F3 Metabolic pathways that produce and interconvert acyl-CoAs involved in histone acylations PDC CDYL ACSS2 ACLY GCDH PMC7510089__F5 Key genes analysis in the AD PIK3R1 NGF MYC CXCL8 PTEN PARG PRKCA PDGFD CCND1 KITLG CDC2 JUN FGF7 ANGPT2 RAPGEF1 KIT FGF2 VEGFA CD44 IL6 ADCY3 ANGPT1 VEGFC PDGFC CXCL12 EPHA2 PPARG STAT3 PMC8290582__F3 Alpha- and Beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease BAD FOS SMAD2 GRB2 SMAD4 RAF1 TGFBR3 JUN PMC7510089__F4 Key gene analysis in the OS PIK3R1 FOXM1 ACTA2 EGFR GADD45B MMP2 POLR2A CCNB1 GABARAPL1 JUN RHOB SGK1 EGR1 FGF2 PLK4 CD44 GADD45A CEBPA IL6 IRS1 AURKA BCL6 ALPL APOB VEGFC CCNB2 TYMS CXCL12 BDNF PPARG STAT3 PMC7500440__F1 Pro-tumour activities of neutrophils.a) Neutrophils can express ligands of immune checkpoints expressed on T cells, such as PD-L1 CXCR1 EGF MMP9 IL8RB ARG1 IRS1 PMC6770430__F2 Hyperglycemia associated metabolic reprogramming in cancer cells and potential targets TIGAR HEL-S-30 TG HEL-S-162eP PMC8313570__F1 Regulatory pathways of ferroptosis GPX4 HEL-S-64p POR GLS PMC5835589__F1 Targeting DDR vulnerabilities of SCLC WEE1 ATM CDK2 MYC CDC25B RB1 ATR PMC545806__F7 Different pathways use the RecQ helicase in response to replication stalling MRC1 RAD51 PMC9099610__F2 Poultry Meat and Eggs as an Alternative Source of n-3 Long-Chain Polyunsaturated Fatty Acids for Human Nutrition ELOVL5 ELOVL2 GLA PMC6763782__F3 Regulation of the main phases of the autophagic pathway by the C2‐WW‐HECT E3s UBC ULK1 ATG101 UVRAG WWP1 PMC10253478__F1 Action of probiotics CORT MUC1 MUC13 MUC5B MUC2 TLR10 FOXP3 MUC4 GC MUC6 IL2 IL4 BDNF PMC4404113__F5 Unigenes involved in the three metabolic pathways GDA AIDA PMC8008218__F6 Study findings CDH2 PMC9561884__F4 Roles and targeting options of TRIM family proteins in tumor KY TRIM67 TRIM52 TRIM46 CDK19 CACTIN KIN WAS TRIM27 TRIM44 TRIM39 PMC5614325__F2 SASP regulation ATM NOTCH1 MTOR BRD4 PMC9561884__F5 Roles and targeting options of TRIM family proteins in tumor TRIM11 TRIM45 TRIM32 TRIM66 GSK3B TRIM27 MTOR TRIM44 TRIM47 TRIM26 TRIM59 STAT3 PMC4771746__F2 Example pathway (Alzheimer's disease) overlaid with gene expression data from BBB cell line BACE1 BAD GSK3B ATP2A1 TNF HEL-S-162eP CASP3 APAF1 LPL ERN1 APP CASP9 ADAM10 RYR3 MME CASP8 IL1B FADD SDHA CYCS APOE PMC11808201__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation ST3GAL3 MAGT1 VMA12 ATP6V0A2 TRAPPC11 SLC39A8 COG8 FCSK COG7 SSR4 SSR3 PRKCSH COG1 VMA22 OSTC DPM2 VMA21 RFT1 SLC35A1 ALG3 SLC35A3 TMEM165 ALG6 ALG10 COG6 GMPPB COG5 COG3 B4GALT1 TUSC3 MAN1B1 GANAB ALG13 NUS1 SLC35C1 COG2 ALG5 SRD5A3 ATP6AP2 DOLK DPM3 DHDDS DPM1 STT3A STT3B MGAT2 DDOST PMC12212355__F2 Preventing T cell exhaustion and enhancing cytotoxicity through metabolic reprogramming IL10 GNLY HEL-S-11 RASA2 ZAP70 ADRB2 SIRT1 BATF PMC2043390__F9 Biphasic expression and up-regulation of HWP1 at the bud-hypha transition CAP1 NRG1 CDC42 PMC6037732__F8 Cell cycle arrest and apoptosis of hepatocytes PPP2R5C CCND1 CCNE1 PMC3059259__F2 Autophagy, inflammation and neurodegenerative disease TNF IL1B IFNG PMC3367549__F4 BMP signaling pathway and regulation of SMAD activity SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC3367549__F3 Sonic hedgehog (SHH) signaling pathway BOC NKX2-2 KIF7 SUFU PTCH1 GLI3 SHH RAB23 SMO GAS1 PMC8576332__F7 Suppression of EGFR/PKCD/NFKB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer EGF MMP9 EGFR FADD PMC5770391__F4 Changes in brain energy metabolism during worker maturation elucidated by pathway analysis of data from brain RNA-seq experiments CS PC FH OGDH ACLY DLAT PMC7885061__F2 Altered gene expression profiles and signaling pathways in vitiligo RPS6KB1 PDC USF1 DCT TYRP1 BCL2 TNF PTPN22 FOXP3 PMC8211512__F2 Mitochondrial Quality Control in Cardiac Ischemia/Reperfusion Injury MFN2 BNIP3 TFAM PMC3864900__F6 Ubiquitylation in immune defence and pathogen evasion BCL10 TRAF6 ITCH PMC3428099__F1 FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators EGF BAD BRAF FAM83A EGFR MYC GRB2 FAM83B MCL1 MTOR PMC3864900__F3 Ubiquitylation in immune defence and pathogen evasion TBK1 TANK MIB1 TRIM56 IRF3 TRIM25 NOD2 MIB2 TRIM23 PMC9018712__F10 Compound mutant phenotypes of Vangl2, Grhl3, Usp39, and Ube1 genes during mouse development and schematic model of USP39/GRHL3 complex in the de-ubiquitination pathway GRHL3 PMC5562757__F9 Mechanistic model for ATF3-mediated negative regulation of antiviral and autophagy pathways in the absence of type I IFN STAT1 ISG15 STAT2 IRF9 ATF3 DKFZp686F0183 PMC8888345__F2 Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition TSC2 DDR1 TSC1 CDKL5 FRK FOXA1 CDK19 EGFR MYC SRC MTOR RHEB PMC3367549__F2 Canonical (left) and noncanonical (right) WNT signaling pathways DAAM1 FOS GSK3B LRP5 LRP6 RHO JUN PMC3367549__F1 FGF signaling cascades, an example of RTK signaling BAD FRS2 FOS GRB2 ETV4 RHO RAF1 ETV5 JUN CDC42 PMC11202107__F1 Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis SOCS3 STAT4 TYK2 JAK3 IL6 JAK1 SOCS5 GATA3 STAT3 PMC7409382__F1 S1PRs signaling regulating endothelial barrier function S1PR2 S1PR3 SPHK1 RHO RAC1 SPNS2 PMC2983445__F3 Growth factor signaling pathways mediating survival in multipotential stromal cells EGF BAD HGF EGFR BCL2 FOXO1 PMC2983445__F2 Growth factor signaling pathways mediating proliferation in multipotential stromal cells EGF WNT3A HGF BMP2 SMAD2 APC EGFR SMAD4 CCND1 PMC6273666__F6 The possible inhibitory mechanism of ethyl acetate fraction of M COX2 TLR4 IL6 IL1B PMC9502517__F2 Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach CASP3 CASP8 FADD PMC8591777__F5 Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma PC IMPACT EN2 EN1 PMC3467044__F9 Model depicting the molecular underpinnings of lamin B2 origin licensing TDG CDC6 MYC ME3 CDT1 ORC2 TET2 PMC3678724__F1 Alterations of the AKT pathway in human cancer NF1 TSC2 BAD TSC1 MDM2 VHL CCND1 PTEN EIF4E PHF20 RHEB PMC6056347__F3 The complex interplay between ER stress and liver damage and transformation(1) Unremediable ER stress in hepatocytes can elicit cell death, which might proceed through apoptotic, necrotic, or pyroptotic pathways or a combination thereof CASP3 NLRP3 IL16 PMC10556370__F3 Mechanisms underlying TAX-mediated neuroprotection against AD or CAA BACE1 APP SIRT1 APOE PMC6716635__F3 Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance FOXM1 NPPB MYL3 THBS4 RCAN1 CTGF BCL6 NR1i1 NPR3 HEY2 KCNJ2 ATP2A2 RAF1 KCNJ5 ACE2 ALDH2 PMC3292500__F3 Top scored pathway map affected by BaP "Apoptosis and survival_Endoplasmic reticulum stress response" EIF2S1 ATF4 BAX PMC4732899__F6 Epidermal growth factor receptor signaling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease AREG APC EGFR IL17A IL4 PMC9320762__F4 Non-Canonical Programmed Cell Death in Colon Cancer RIPK1 TLR4 RIPK3 FADD TLR3 MLKL PMC9320762__F2 Non-Canonical Programmed Cell Death in Colon Cancer GPX4 FACL4 IREB2 TFRC TF PMC9320762__F1 Non-Canonical Programmed Cell Death in Colon Cancer ATM CDK2 SSB CDC2 ATR PMC11011199__F2 Prediction of Response to Anti-Angiogenic Treatment for Advanced Colorectal Cancer Patients: From Biological Factors to Functional Imaging BAD GRB2 SRC PTEN RAF1 PMC5626732__F8 Signalling disruptions in Depdc5 FS/FS mice TSC2 NPRL2 TSC1 C16orf35 DEPDC5 IRS1 PMC2700035__F6 Load-driven signaling pathways predicted with ankle loading at 1 h after the last loading FST CD47 APC PROC SKA1 CER1 SMAD4 CHAD GK3 ARHA RB1 PMC6295338__F3 TPS EGF Response Pathway Model PLCG1 EGF MHC2TA MAPK9 ATP1A1 CSNK2A1 EGFR MAPK3 RNF213 SPRY1 ERF PAG1 CRKL EPN1 BCLAF1 DOCK4 HGS MAPK1 TOM1L1 CD2AP INPPL1 IRS4 AKAP12 c-fgr PRPSAP1 RUNX1 ARHGEF7 PS1TP5BP1 CBL TUBA1A PAK1 MAP2K1 WASL TXN2 GRB2 WIPF2 ATXN2 EPHA2 SHC1 PTPN18 PMC3442837__F1 Regulation of phenotypic transitions in the fungal pathogen Candida albicans NRG1 CDC42 PMC1852792__F6 A hypothetical model for association of four subcomplexes in the FA core complex FAAP24 UBE2T PMC3169732__F6 Schematic diagram illustrating the proposed signaling pathway involved in cigarette smoke extract-induced increase in expressions of inflammatory genes in airway smooth muscle cells TLR4 TRAF6 MYD88 PMC5627668__F1 N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities TH FAAH TRPV1 PMC8810792__F7 Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71 TNFRSF9 PLAT BIRC3 RELB PTGES CCL2 TNF PMC8822417__F8 Activation of PPARG in bladder cancer via introduction of the long arm of human chromosome 9 FOXA1 PTEN PPARG GATA3 PMC12199311__F7 Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling CCND1 HES7 STAT3 PMC6761106__F2 Suggestive model for receptor-mediated pathway involved in CD biology TLR4 MOG ABCF1 TRAF6 SMO FAT10 MYD88 TNF PMC7801250__F3 Synopsis of lysine monomethylation events involved in photosynthesis and carbon metabolism in SynechocystisA FES CYB CP SDHB PMC6226306__F1 New Therapies in Head and Neck Cancer EGFR MTOR STAT3 PMC8076159__F6 Novel circGFRA1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14 METTL14 GFRAL PMC7063815__F1 Relationship between mTOR and tumors RNF168 OTUD7B PTEN MTOR H2AX DEPTOR TRAF2 RHEB PMC8994166__F5 Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation MFN1 MFN2 OPA1 PMC7876650__F2 Contrast effects of autophagy in the treatment of bladder cancer TSC2 ULK1 TSC1 TFEB ZKSCAN3 ATG101 ULK2 RHEB PMC4601263__F5 CLN3 and sphingolipid signaling pathway interactions analyzed using Pathway Studio SMPD1 CLN3 UGT8 DEGS2 CERS2 CERS6 PMC9354743__F2 RNA m6A modification orchestrates the rhythm of immune cell development from hematopoietic stem cells to T and B cells YTHDF2 TH METTL14 METTL3 PREB PMC7758733__F7 Proposed signal transduction pathways by which quercetin induces apoptosis in AML cells IGF1 BCL2 MTOR BAX PMC6838415__F8 Gut microbiota from colorectal cancer patients enhanced the progression of intestinal adenoma in Apcmin/+ mice NLRP3 APC IL1B PMC7437582__F1 New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target? APC PTK7 RYK PMC5039377__F4 DNA-damage response pathway-network ATM RPA1 MYC ATF1 XPC NBN XPA DDB2 MSH2 ATR UNG PCNA PMC8847669__F1 Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization TNLG8A CXCL8 CD40 TRAF2 PMC11619685__F4 Activation of the p38 MAPK-mediated senescence pathway can occur because of pH changes or stimulation of ASIC1 or ASIC3, which initiates the ATM/ATR pathway ASIC3 ATM CDK2 CDK4 MTOR ATR SIRT1 CDK6 PMC8009543__F1 NLRP3 activation NLRP3 MFN2 TXNIP MYD88 IL1B MAVS PMC5650369__F8 Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages JAK1 DKFZp686F0183 STAT3 PMC3169577__F1 Evolution of the TGFB Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC8603464__F1 Regulatory role of the transforming growth factorB signaling pathway in the drug resistance of gastrointestinal cancers SMAD2 CXCR4 MSC SNAI2 SMAD4 CDH2 CD24 PMC11619685__F2 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration NLRP3 GSDMD DFNA5 PMC10669584__F1 APE1/Ref-1 role in inflammatory bowel disease and the potential of redox signaling inhibition TLR4 TF STAT3 PMC11619685__F1 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration BAD BCL2A1 TNF FADD BAX PMC7167255__F7 STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch–mTOR signaling pathway STYX MTOR FBXW7 BAX PMC2819730__F1 Urine-based assays for the detection of bladder cancer HHIP TGFBR1 BMP7 LRP8 ATF3 TFRC CTNNA1 FKBP1A FLT1 AMFR ERBB2 LEPR SPHK1 CYP20A1 GNB1 APOE F11R PMC9456256__F2 Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain ChAT CS CIC ACLY PMC2948663__F1 Molecular and genetic events in mammalian sex determination and differentiation DHH EMX2 NR5A1 LHX9 DMRT1 PBX1 WT1 FOXL2 GATA4 SOX9 FGF9 SRY CBX2 RSPO1 AMH WNT4 PMC2675653__F1 CART analysis of NER pathway and esophageal cancer risk ERCC1 XPA PMC6952788__F6 Cartoon illustrating the role of RAC1B in negative regulation of the epithelial-mesenchymal transition (EMT) program in (pancreatic) epithelial cells SNAI1 TGFB1 PMC4389820__F1 Major interconnected signaling pathways that regulate EMT HEL-S-28 TRAF6 SMO ARHA CDH2 PMC3458820__F8 Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice CYP2R1 CYP24A1 CYP27B1 PMC4926486__F12 Mechanism of cell death in murine lung epithelial cells after repeated cycles of hyperoxia, radiation, and double-hit combination challenge CASP3 BCL2 BAX PMC8895238__F1 Hypoxia in the Interferon Response TBK1 CGAS STAT2 IRF7 IRF9 DDX41 IRF3 IFNAR2 IFNAR1 TLR3 STAT1 ADAR TYK2 JAK1 MAVS IFI16 PMC6672053__F4 Cellular response to T–R conflicts FANCD2 BRCA2 FANCM ATR BRCA1 PMC3572003__F1 Altered energy metabolism in cancer MYC PTEN HEL-S-133P PMC8754411__F8 Schematic drawing showing that MSC-exo eye drops alleviate GVHD-associated dry eye disease by reprogramming M1 macrophages to M2 via miR-204–mediated targeting of IL-6R/Stat3 pathway CD9 CD63 ARG1 CD81 STAT3 PMC8841219__F2 The renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19) ACE2 PMC9035226__F6 Summary & conceptualized pathway CXCL1 RUNX2 CCND1 CDC2 SMURF1 ID1 RHOU PMC1538848__F3 Expression data analysis and visualization on the PANTHER website FER LAT PMC7577645__F2 TNFA and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis TRADD EEA1 RAC1 TNF TRAF2 NOXA1 PMC6591147__F3 Mechanisms promoting regulatory T cell (Treg) development and immunosuppression in the tumor microenvironment CDK2 CCR4 SMAD4 CCL22 FOXP3 PMC7885861__F1 Expression and function of the insulin/insulin-like growth factor system in glioblastoma cells HEL-S-28 EGFR IGFBP2 PTEN MTOR IRS1 INSR STAT3 PMC6444363__F6 Tat promotes astrogliogenesis over neurogenesis through its binding to Notch to activate the Notch signaling pathway HES5 RBPJ HES1 PMC12211004__F7 Schematic diagram regarding key parts of this study OSM OSMR PMC7138577__F7 Proposed model of the combinatorial effect of DDP and melatonin on NPC cells APC WNT1 GSK3B CD44 SOX9 CCND2 PMC9496650__F2 Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways APC GSK3B AXIN1 PMC10987652__F7 GSK3B inhibition inhibits microtubule dynamics TTL MAP1B SVBP VASH1 PMC10239817__F1 Peptides in reversing chemoresistance of breast cancer: current facts and future prospects SNCG ERBB2 PMC2772826__F1 Apoptosis in animal models of virus-induced disease DIABLO FADD BAX PMC7722149__F1 Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? MAPK1 MTOR PMC10375937__F13 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC11890417__F8 The role of LINC01305 and LAD1 in ESCC CDH2 LAD1 PMC3606520__F6 Summary of the putative biosynthetic pathway of non-arthro and arthro-series neutral GSLs in the cyst of the brine shrimp CER1 ICOS PMC3155178__F1 Synthesis of Dihydrotestosterone via the Classic and Alternative (Backdoor) PathwaysThe classic pathway of steroidogenesis leading to dihydrotestosterone is shown on the left, and the alternative pathway is shown on the right CYP11A1 HSD3B2 HSD17B2 POR HSD17B3 AKR1C2 CYP17A1 PMC2546909__F1 Signal transduction pathway elicited by Env interaction with CCR5 required for Rac-1 activation and membrane fusion TIAM1 CCR5 TG PMC10887283__F2 Therapeutic potential of anti-IL-1 agents in hidradenitis suppurativa CXCL1 IL1A IRAK1 IL36A IRAK2 IL36B CXCL8 CD83 IL1R1 IRAK4 CXCL2 MYD88 CCL20 CD80 IL1B PMC5564228__F2 Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases TBK1 STAT1 CGAS STAT2 IRF9 IRF3 TYK2 JAK1 PMC7727076__F6 p53 signal pathway and cell cycle pathway regulated by CDK1 and CCNA2 in pancreatic adenocarcinoma (PAAD) CA14 WAPAL PTEN DBF4 RFWD2 TSC2 CASP3 FER CDR2 SIAH1 AIFM2 PERP ATM CDK2 MDM2 CASP9 CDK4 ATR PCNA SKP2 MYT1 PMC3540985__F1 CYTOKINES, INFLAMMATION AND COLON CANCER TLR4 RELA TRAF6 MYD88 PMC10375937__F14 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC8023278__F10 Estrogen signaling pathway ranked first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms PGR KRT19 TFF1 HEL-S-11 GRB2 EBAG9 TGFA HEL-S-130P PMC8079281__F8 TGF-Beta-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity VAV1 ARHGAP24 RAC1 ARHGAP22 VAV2 PMC8023278__F11 Osteoclast differentiation signaling pathway ranked twenty-first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms SOCS2 CTSK IRF9 OSCAR MAP3K7IP1 FRY BTK CYLD FHL2 GRB2 SRC SYK TGFA SIRPB1 SOCS1 PMC6289038__F2 Protein–protein network and pathway analysis PIK3CD MAPK8 MAPK3 ALB MYC ALOX12 NRAS MAPK14 STX1A ALOX5 BCL2L1 HIF1A PTGS1 PRKCA DCN A2M DFFA MMP2 APAF1 TIMP3 PICK1 SRC MAPK1 CDH2 ACAN IL10RA APOE PLG FOS VEGFA TNF HRAS DIABLO HIF1AN IL10RB RICTOR TIMP1 IGF1 SUFU BCL2 EGLN2 MPO BRAF PTEN BCL2L11 EIF4EBP1 MTOR PLD2 BIRC3 APP IL2 hEMMPRIN IL4 JUN PTGES3 BAX IL10 PTGIS SDC1 FOXO3A MMP9 PTGS2 CD44 PTGES VHL ARHA RAC1 IL6 EGLN1 CASP3 CTSG BIRC2 EGLN3 CREBBP SDC4 BBC3 NFKB1 TNFSF10 PLA2G1B RELA PMAIP1 AHSG PIK3CA JAK1 MCL1 PLA2G2A CYCS PMC9405677__F18 Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease IGF1R CALB2 ASCL1 CDH11 GSK3B NAPB CREB1 FMR1 SLC6A11 PENK HMOX1 EPHB3 DLG4 PDYN PRKCA TNFSF6 GRM2 CAMK4 PNOC F2 FOSB APP CALB1 CASP8 JUN APOE LIMK1 SOX2 SYT4 FOS SYN2 PTGS2 GRIA3 TCF7L2 STX1B TNF PIK3R3 GABRA4 CASP3 KMT2A EGR4 VAMP2 GABBR2 CREM ARC CAMK2A AKT3 PMC6322225__F4 Treatment to health (HTD) network PC A2M LPL DES ACD PMC8301018__F5 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus MMP9 AKR1B1 CDH2 PMC9307586__F12 MicroRNA expression profiling of endocrine sensitive and resistant breast cancer cell lines PIK3R1 COL3A1 ATP1B1 ADAM12 GSK3B FBN1 PTPRN2 PTEN CCND2 VAPA SNTB2 PSD3 MDM2 CAV2 COL2A1 GATA3 CLDN11 CCDC81 F11R LOXL2 COL4A4 RNF43 PDGFRA HEL-S-79 MAPK10 UBE2H VEGFA RAB31 TCF7L2 PBX1 COL5A3 ITGB1 COL5A2 BIRC2 IGF1 THBS2 LAMC1 COL4A2 CDC42 AKT3 COL4A1 PMC4918817__F2 Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing, and disease MYF5 FOXO3A FGF2 PAX7 NOTCH1 PMC6925523__F3 Cellular signalling pathways in response to pathogenic viral infection or mtDNA release NLRP3 CGAS TLR9 IRF7 IRF3 MAVS PMC8132124__F3 Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst ATM YAP1 SRM HEL-S-44 PMC8596933__F6 CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/Beta-catenin signaling pathway AXIN2 CXCL14 PMC3140170__F10 Nicotine signal transduction pathways BAD RAF1 PMC7685213__F1 Simple Rx for congenital erythropoietic porphyria ALAS1 FECH UROD UROS HMBS ALAS2 PMC5267352__F1 Reviving the promise of transcription factor Nrf2 based therapeutics for kidney diseases KEAP1 GSTM1 ENTPD5 HEL107 NQO1 PMC6193498__F1 Homology-directed repair (HDR) and other pathways for the repair of double-strand breaks (DSBs) PALB2 BRCA2 RAD51 BRCA1 PMC10813911__F3 Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury SMAD2 GFAP PMC1502564__F3 Model diagrams indicating regulation and function of E47 activity SOCS3 GFI1 GFI1B PMC3967838__F1 DNA2 Resolves Expanding Flap in Mitochondrial Base Excision Repair FEN1 DNA2 PMC5450421__F4 Key enzymes in the glycolytic, pentose phosphate, pyruvate, and UDP-N-acetyl-galactosamine pathways are upregulated in the in vivo Giardia foci MAL PMC12222133__F3 Apoptosis in NPCs APAF1 MCL1 FADD BAX PMC12222133__F6 PANoptosis in NPCs CASP6 NLRP12 RIPK3 ZBP1 GSDMD CASP3 NLRP3 RIPK1 CASP8 AIM2 FADD MLKL DFNA5 PMC8274905__F6 Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NFKB Signaling Pathway in Bovine Mammary Epithelial Cells COX2 LTA GPX1 IL1B PMC6015873__F1 CAMKK2 as a molecular hub downstream in the bone–prostate cancer (PCa) microenvironment BMP2 NFATC1 NUP62 CAMKK2 PMC5796897__F3 The fatty acid (FA) synthesis in different cell types LPL ACLY TG FASN CD36 PMC10778290__F7 Schematic diagram shows that tumor-derived ESM1 combines with the c-Met expressed by endothelial cells to promote GC peritoneal metastasis by inducing angiogenesis MMP9 ESM1 VEGFA HIF1A PMC5064021__F9 Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals IL10 LAMTOR1 ARG1 IRF4 PMC8535522__F1 Development of New Cancer Treatment by Identifying and Focusing the Genetic Mutations or Altered Expression in Gynecologic Cancers WEE1 ATM BRCA2 EGFR MDM2 PTEN CDC2 MTOR ATR BRCA1 PMC8055404__F3 Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions MAPKAPK2 EZH2 MTOR PMC3667790__F7 DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway MMP7 DSG3 CCND1 PMC8602894__F7 Hsa_circRNA_103124 Upregulation in Crohn’s Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway TSC1 CDK2 PMC5480600__F3 Tumor-Associated Macrophages as Treatment Targets in Oncology CCR5 COX2 CD47 CCR2 COX1 CD40 CCL5 SIRPG PMC8148341__F2 Microglial Exosomes in Neurodegenerative Disease RAB35 MOS PELI1 YKT6 PMC8148341__F1 Microglial Exosomes in Neurodegenerative Disease CD9 CD63 VTI1A CD81 VTI1B PMC8461092__F2 Interaction Between PEDV and Its Hosts: A Closer Look at the ORF3 Accessory Protein EIF2A TNF VPS36 PMC5494974__F3 Haploinsufficient tumor suppressor genes EGR1 ATM CDK2 MYC CDK4 JUN CDK6 PMC4545641__F1 The Expanding Role of Delta-like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC5517784__F5 Figure illustrating cumulative flux index in glycolysis, TCA cycle and electron transport chain in glucose metabolic pathway CS FH OGDH MDH2 HEL-S-162eP PMC8706317__F2 Improving the Health-Benefits of Kales (Brassica oleracea L. var. acephala DC) through the Application of Controlled Abiotic Stresses: A Review KEAP1 SFN PMC5494974__F5 Haploinsufficient tumor suppressor genes TSC2 TSC1 FOXO3A SMAD2 SMURF2 SMAD4 SKI SMURF1 PMC6042022__F7 Interactions between membrane–lipid metabolism, APP processing and Beta-secretase (BACE) activity, cholesterol uptake/efflux and cell cycle regulation BACE1 CKS2 PERP PLK1 CDK2 ABCG1 LDLR APP S100B APOE PMC8705541__F2 Thyroid Hormone Nuclear Receptor TRA1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer APC TCF4 PMC11590683__F1 Catabolic pathways of glucose metabolism in KT2440 RPIA TNLG7C RPE PMC6445864__F7 Schematic illustration showing anti-inflammatory responses in RAW 264.7 cells after treatment with AS-6 TLR4 MYD88 TNF IL1B PMC4368090__F3 Interleukin-1B and its interacting proteins in Alzheimer’s disease TH CD14 BAD CS EGFR ARHA TNF BCR LYN SYK IL4 GAL MEF2C LAT TIRAP PMC6538222__F3 The Keap1-Nrf2-ARE pathway MAF KEAP1 RBX1 PMC3154190__F5 Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics CLTA LYZ PF4 Nbla10317 ALOX15 LCN2 CREB1 HEL-S-7 PPBP HLA-B PS1TP5BP1 HLA-C CSTA NOLC1 GP5 VAMP2 PTK2B VWF THBS1 ARG1 GP1BA RHOB CD2AP APOE PMC9071071__F3 Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine KISS1 SIRT1 EED PMC7306218__F4 Identification of hydatidosis-related modules and key regulatory genes NR3A2 NODAL GDF3 CLU UGT2B15 PMC2929951__F8 Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome ROCK2 APC GSK3B GPX1 MYC NEF3 ARHA NEFH CBL DAAM1 GRB2 SRC TGFA JUN NEFL PMC4000238__F2 The canonical Wnt, Ihh, Bmp and PTH/PTHrP signaling pathways in regulating the differentiation of mesenchymal precursors IHH RUNX2 PTH COL2A1 SOX9 PMC4000238__F1 Wnt pathway and its interactions with other pathways in bone PTH1R RUNX2 APC PTH ROR2 JUN ROR1 PMC9331941__F1 Immune Checkpoint Inhibitors in Cancer Therapy—How to Overcome Drug Resistance? BTK SIRPA CD47 HEL-S-92n CD80 TIGIT LAG3 STAT3 CD24 PMC5912161__F1 Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway NHS MAL PMC3603002__F6 T cell signaling pathways and protein phosphorylation sites identified to be differential between NOD and B6g7 mice in stimulated cells TXK CD5 CSK RHO PAG1 ITSN2 LCK PTPN11 PTPN6 SHC1 PXN LY9 LAT CDC42 PMC2661789__F1 In endothelial cells, after activation, VEGFR2 is able to stimulate the AKT/mTOR signalling pathway through PI3K ELF3 PDK2 VEGFA PTEN RHEB PMC3852343__F3 Oxygen-regulated COX subunit isoform switch in yeast and mammals CYC1 COX5A PMC9658148__F3 Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology NODAL PITX3 HEL-S-101 SHH FOXG1 TFAP2A DLX5 FSHB SIX1 PITX1 SIX6 KRT14 PMC6325770__F7 Proposed CLIC4/Arf6 signaling pathway RAB35 AGAP1 BMPR2 GIT2 ARF6 PAH CLIC4 AGAP2 PMC9199004__F5 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways MAP2 TLR9 RASD1 RUNX2 IRAK1 MAPK3 TRAF6 PTEN BCL2L11 CTGF OSMR CBFB STAT1 MMP3 TLR4 MTDH NEUROD1 JUN CHI3L1 IFNB1 BCL6 MAP2K1 GRB2 TYK2 IL6ST HEL113 ATP2A2 JAK1 RAF1 TNFRSF10B PTPA OSM SHC1 STAT3 PMC9199004__F4 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways SLC25A32 MAP3K11 IFITM3 TGFBR2 SMAD4 CCL5 PTEN MYD88 FMR1 CEBPG E2F3 CBFB IFNG DICER1 IRF-1 IRF4 HK2 IL10 IL1A SCARB1 CXCL10 JARID2 PIGR CALM1 CASP3 IL7 IGF1 LIPA TNFSF10 SGPL1 TGIF1 DENR C10orf104 PMC6385418__F1 Homologous recombination (HR) repair deficiency represents an opportunity for a synthetic lethality approach through the use of PARP inhibitors (PARPi) SSB PARP1 PMC9199004__F7 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways SRC CDC42 PMC3978568__F1 Schematic representation and overview of PTEN/PI3K/AKT signaling and a model of the mechanism of peroxisome proliferator-activated receptor (PPAR) action TSC2 TSC1 PTEN MTOR PMC11123998__F5 Supplementation influences the metabolic reprogramming of cumulus cells in aging ovarian patients CS ENO1 HEL60 HEL-S-32 HEL-S-26 FH ACO2 ENO2 SUCLA2 HEL-S-133P SDHA HK2 HEL-S-281 SDHB PMC6243101__F1 Autophagy as an anti-inflammatory process IL18 MTOR IL1B PMC8339131__F8 TRAIP as a key prognostic DEG between CTCs and metastatic lesions in osteosarcoma KANK1 TRAIP PMC8444451__F4 Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice RUNX2 TP63 RARA FOXD3 WNT3A APAF1 FOXP2 FOXG1 SHH DVL2 AXIN2 NR3B3 FOXE1 PMC4376601__F1 Sphingosine-1-phosphate receptor 2: a novel bile acid receptor and regulator of hepatic lipid metabolism? IL16 VLDLR S1PR2 PLTP FGF19 FGFR4 IRS1 NR1C1 MTTP CYP7A1 PMC3096022__F1 Biochemical pathways leading to the synthesis of TAG and cholesterol SCD HMGCR FASN PMC4737457__F4 Crosstalk between Wnt, Notch, and JAK-STAT signaling pathways RBPJ BMP2 STAT3 PMC11039990__F7 Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis INA TF PMC8306599__F2 Advanced Glycation End Products: New Clinical and Molecular Perspectives STAT1 VCAM1 JAK1 PMC4621888__F1 Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder STAT1 KIT PAK1 ROCK1 GAB2 ASXL1 ARHA RAC1 STAT3 TET2 PMC11147929__F6 LSS affects endothelial cell pyroptosis through IKKE/STAT1/NLRP3 signaling pathway STAT1 NLRP3 IL18 GSDMD PMC3192838__F7 Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response ISG15 EIF2A TRAF3 TRIM25 MAVS PMC11858545__F8 Danggui Beimu Kushen Pill Alleviates Colitis-Induced Inflammation in Mice by Regulating the IL-6/IL-6R and IL-17A/IL-17RA Signaling Pathways TRAF6 JAK1 STAT3 PMC4600500__F4 Interactomic analysis by ingenuity pathway analysis (IPA) of significant molecules RELA CXCL8 CCL2 REL IFNG PMC4772101__F2 Mechanical signaling and tissue growth PMC8825714__F5 UHPLC‐QTOF/MS‐based comparative metabolomics in pectoralis major of fast‐ and slow‐growing chickens at market ages ChAT GDE1 GPCPD1 PHOSPHO1 ACHE PMC8024479__F3 Intrinsic apoptotic pathway ATF4 EIF2A MDM2 DIABLO TRAF2 SPHK2 HTRA2 BAX PMC5037772__F5 Pin1 regulates multiple signal transductions in metabolic organs PIN1 RUNX2 SMAD2 DCSTAMP CRTC2 MEF2C IRS1 STAT3 PMC8458575__F2 Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism TSC2 TSC1 ATF4 CAD MTHFD2 PMC5037772__F4 Pin1 has biphasic effects on insulin signaling PIN1 PI3 IRS1 PMC6089072__F3 Methods for observation and quantification of apoptosis OMP TNF PMC7276052__F7 Main components of RAAS pathway active in small bowel (SB) Crohn’s disease (left) compared to non-IBD (right) SLC6A19 ACE2 PMC7826706__F1 Hedgehog (Hh) signaling pathway contributes to hepatic carcinogenesis SUFU SMAD2 PTCH1 ABCC1 CD44 SMAD4 SMO PMC6403405__F8 Functional mechanisms of COL2A1 on the BMP-SMAD1 pathway BMPR2 SMAD4 ITGAX ITGB1 SMAD1 PMC8389254__F3 Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?” ULK1 LAMP2 BNIP3 MTOR PMC6942938__F1 Proteome alterations in aqueous humour of primary open angle glaucoma patients DKK3 WNT1 AXIN1 ARHA RAC1 APC2 WIF1 PMC11360076__F4 Protein–protein interaction map of the upstream regulators that significantly altered after the exposure to V PIK3R1 UCP1 ALDH3A2 NRAS FMR1 OVOL2 SELL MYO1B SLC2A3 HTT NUP133 RAD51 HELLS COL18A1 PLAUR FOS EP400 MAP2K5 RGS2 SPNS2 IL15 CUL4B TPP2 STK11 HEL-75 ADAM10 ARNT2 ALDH2 SGPP2 ZFHX3 LARP1 SELENOW CHTOP PTEN WTAP XBP1 RNF5 ATF4 RCN3 RBM47 PBR TRAPPC1 CLPP CD3D TRIM2 CGA MAP3K12 HSF2 FUS PRL ADORA2A HNF4A MLXIPL STAT4 CYP27B1 PMC2730725__F1 Nm23-H1suppression of tumor metastasis may depend on at least three pathways L1CAM SET STRAP PMC3248218__F3 NUAK2: an emerging acral melanoma oncogene TSC2 TSC1 MTOR RHEB PMC6628314__F1 Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer NRG3 EGFR NRG2 SRC NRG1 PTEN NRG4 PMC4544004__F8 The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway TLR4 TRAF3 TRAF6 IRAK4 FADD MAL PMC9116428__F1 Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NFKB Signaling Pathway TRADD TRAF3 CXCL8 TRAF6 CCL2 MYD88 MTOR TLR4 ECSIT CD80 BDNF TRAF2 FADD PMC4544004__F1 Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 FADD MAL PMC8175077__F2 Intracellular Free Neu5Ac Metabolism and Associated Genetic Disorders GNE SLC35A1 SLC17A5 NPL PMC10993482__F5 Gal-1 pathways promoting EMT in cancer TLR4 SMAD2 SMAD4 S1PR1 MTOR PMC10993482__F4 Gal-1- and Gal-3 pathways promoting EMT in fibrosis SMAD2 SMAD4 PMC5731874__F6 Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells TM4SF4 GSK3B CD44 SRC STAT3 PMC4032097__F9 CNTF-induced gliosis in the retina after ONC and Pen1-C6DN + siCASP2 treatment CNTF CASP6 CNTFR CASP2 PMC7829348__F2 Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions TBK1 CD14 TLR4 IRAK1 TRAF3 LBP TRAF6 IRF3 IRAK4 MYD88 TIRAP TAB3 PMC11566834__F8 Optogenetic stimulation of the “Zusanli” acupoint alleviates inflammatory pain through active Wnt/Beta-Catenin and MAPK signaling pathway in rats APC GRB2 PMC10993482__F6 Gal-3, Gal-4 and Gal-8 pathways to EMT in cancer IGF1R RUNX2 EGFR PMC9496846__F4A Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE) EGF XPOT HEL2 TUBB NR3A2 CTCF EGFR HNRNPL MYC TCF12 MAP2K3 CFTR CBL VAPA EP300 MAX SMC3 APP SYK HEL-S-93 PCNA KRT10 PMC2901811__F4 II S and TOR-signaling pathway in Drosophila TSC2 TSC1 PTEN RHEB PMC11011897__F3 Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature FGA KRT6A ALB FBN1 COL1A1 CLU HEL-S-78p LAMB1 HSPG2 HP LAMA5 CP TF COL4A2 COL4A1 PMC10458543__F5 Protein interaction network created using STRING database based on Bos taurus genome TLR9 IRF7 TICAM2 CXCL10 TRAF6 IRF3 IFNB1 IL6 MYD88 CD8A IFNAR1 TLR3 NLRP3 TLR7 NFKB1 IL23A CD40 TYK2 PMC7491318__F11 Protein interaction network for 105 DAPs listed in SPARC GLIPR2 SPC24 HMCES TAF9 DNAJB1 HMOX1 PLOD2 FADS3 DHRS1 POLR2B TMSB10 PHLDA3 PNO1 EN1 AXL TSEN15 CTSL CKS2 P4HA2 CHTF18 ADFP CENPE NDUFC2 CDC20 CIRBP MMP14 RASSF1 SDF4 SDCBP C4B_2 UCK2 PLOD1 SIK3 GAS1 CPQ GNG10 COL1A1 EDF1 CD109 GNL2 SLC38A4 DCAF13 POLR2A SERF2 RCN3 NOSIP NUSAP1 TXNDC15 CDK105 HIGD1A SUI1 PTGS2 POLR2G PCOLCE POLR2I ABCF3 PUM3 GYS1 COXFA4 RNF181 DDR2 GC20 POLDIP3 ZWINT JAK1 GRB10 KDM4A PMC7583982__F2 Functions of miRNAs in EOC metastasis CDH2 MTOR PMC3075242__F6 Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APCMin/+) Models of Colon Cancer BAD APC MYC CRK NF1 OCEL1 LEF1 MAX ATM CRP MDM2 JUN FADD RBL1 BAX PMC5882792__F1 Mitochondrial UPRmt and UPRam stress response pathways UBL5 ATF4 ATF5 MAVS CLPP PMC8553480__F3 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer MMP10 RUNX3 LRRK2 MMP2 DLG2 ZEB2 VEGFA SMAD4 PTEN TCF21 BAX PMC9555037__F7 Ruscogenin Protects Against Deoxynivalenol-Induced Hepatic Injury by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through the Nrf2 Signaling Pathway: An In vitro Study KEAP1 GCLC NQO1 PMC8553480__F2 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer AGO2 DGCR8 DROSHA RAN XPO5 PMC2776915__F1 A genetic model for sex determination, controlled by a balance of antagonistic pathways RSPO1 WNT4 FOXI2 FOXL2 SOX9 FGF9 SRY PMC7325493__F1 Complex Signaling Network Driving Macropinocytosis in Cancer EGFR LRP5 LRP6 PTEN RAC1 PMC3249400__F1 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism CRY1 TSC2 ULK1 FOXO3A HDAC7 KLC2 GYS1 CRTC2 HDAC5 IRS1 GBF1 CAMKK2 PMC7291262__F2 MiRNAs/CD133 axis in glioblastoma signaling pathways NOTCH2 PLD2 SHH PMC3249400__F2 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism NF1 TSC2 ULK1 FLCN TSC1 FYN ATM FNIP1 PTEN MTOR MAP3K7IP1 RHEB PMC6332464__F2 Schematic representation of glycolysis, the pentose phosphate pathway (PPP), glutaminolysis and lipid synthesis and their inhibition by polyphenols in breast cancer cells F2 HEL-S-133P PHGDH PMC8421037__F2 YAP/TAZ activity is central to coordinating cell migration TEAD3 ARHGAP18 TEAD4 ARHA THBS1 ARHGEF17 ARHGAP29 TEAD2 PMC8421037__F1 Mitosis by the Hippo pathway and YAP/TAZ TEAD3 APC CTCF TEAD4 LATS1 CDC2 CDK8 LATS2 CDC26 TEAD2 PMC3249400__F4 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism CRY1 HDAC5 SIRT1 FASN PMC8136213__F7 Symbiotic relationship between Caenorhabditis elegans and members of its microbiome contributes to worm fitness and lifespan extension CYS1 SGK1 PNP PMC11936079__F3 Involvement of EMR2 in Wnt/Beta-catenin signaling pathway NF1 FOXL1 PDPN DDX5 AGR3 CHD3 PMC8760362__F2 Zika virus infection of the placenta alters extracellular matrix proteome GCA KIT HP AHSG MICA HEL-S-92n PMC3145765__F9 Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes CASP3 MAP4 TF BAX PMC8772744__F5 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease SMAD2 SMAD4 PMC8772744__F4 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease KEAP1 GSK3B PMC3070572__F4 Schematic analysis of the regulatory pathways in BOO in AROM+/6J male mice COL3A1 PTEN PCNA PMC4648799__F2 P2Y receptor (P2YR) signaling in neurons counteracts oxidative stress and Alzheimer’s pathology APP ADAM10 ADAM17 PMC8772744__F2 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease ULK1 PTEN MTOR PMC8772744__F1 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease RIPK1 TRADD IRAK1 IRAK4 MYD88 TRAF2 FADD BAX PMC2828280__F2 Canonical Wnt pathway TIAM1 MMP3 MMP7 APC LRP5 CCND1 LRP6 ADAM10 BCL9 PMC4061726__F1 Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease LEF1 APC LRP5 ARHA RYK ROR2 GPR49 LGR6 CDC42 PMC3701522__F1 Wnt signalling pathways implicated in diabetic nephropathy DAAM1 APC GSK3B UNK ARHA CDC42 PMC6385756__F7 Diagram depicting the prostanoid synthesis pathway and the effects of PGE2 on its receptor subtypes PTGER2 PTGIR PTGR1 PTGFR PTGS2 PTGES PTGER4 PTGER3 PTGS1 HPGD PTGER1 TBXA2R PTGDR2 PMC8123861__F1 PGC-1A in the Mitochondrial NAD+ Pool in Metabolic Diseases NAMPT NMNAT1 NMNAT2 NMNAT3 PMC5588108__F3 The Hedgehog signaling pathway SUFU PTCH1 SHH SMO BMI1 PMC3705708__F1 Hedgehog Signal Transduction Network BOC KIF7 SUFU SMO PMC9024590__F3 Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells ATM MDM2 HDAC1 BAX PMC7583982__F1 Biogenesis and functions of miRNA PAN2 DGCR8 PAN3 DROSHA PMC2648546__F8 A new feedback loop for p53 pathway CDK2 MDM2 BAX PMC9271889__F5 Autophagy in health and disease: From molecular mechanisms to therapeutic target ULK1 ATG16L1 ATG12 STX17 ACE2 SNAP29 TMEM41B PMC3936891__F1 Overview of the folate-methionine metabolic pathway investigated in this study MTRR PMC9218499__F1 Taste Receptors in Innate Immunity and Oral Health PLCB2 CALHM1 TRPM5 IL25 PMC6789489__F1 Action of methylxanthine (MTXs) in glioblastoma (GBM) GFAP HDAC2 MTOR PMC10034056__F2 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism NFATC1 TRAF6 PMC10034056__F1 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism TRADD NFATC1 TRAF2 PMC2676446__F1 Regulation of p53 and MDM2 and the outcomes of p53 activation ATM MDM2 XPC ATR BAX PMC8834112__F4 Drosophila melanogaster: A Model System to Study Distinct Genetic Programs in Myoblast Fusion PI3 PAK1 ARF1 CRK PMC6441234__F1 Illustrative diagram for exosome-mediated transfer of therapeutic resistance in the tumor microenvironment (TME) TSG101 CD9 CD63 EGFR PTEN RBM11 PMC9035423__F4 Lactate-induced effects on bovine granulosa cells are mediated via PKA signaling VNN2 RGS2 FSHR LHCGR PMC6637313__F1 Cellular and molecular responses to extracellular and intracellular DNA HMGB1 CGAS BCR DNASE2 TREX1 DNASE1L3 CD40 MYD88 DNASE1 IFNG PMC5087334__F6 MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage BCL10 CYLD ARHA RHO TRIO PMC10531837__F2 Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment NF1 BRAF APC GSK3B PTEN PMC10531837__F1 Melanin production PMEL DCT TYRP1 MC1R PMC10531837__F4 Phenotype switching in melanoma SNAI1 SOX2 TFAP2B AQP1 EGFR SNAI2 PAX3 SOX9 FOXD3 MCAM NGFR TWIST1 ZEB2 FAP DCT SOX5 SOX10 AXL SOX6 JUN IRF4 TCF4 PMC10886467__F2 An illustrative representation and overview of PINK1, Parkin, and related molecules in the regulatory pathway for mitophagy TBK1 MFN1 PINK1 MFN2 OPTN PARL PMC7790891__F2 Regulatory network of ginsenosides in macrophage CRP RB1 MTOR PMC9214054__F8 Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism PAQR3 DDB2 PMC7790891__F1 Regulatory mechanisms of ginsenosides in HUVEC KEAP1 VCAM1 RB1 BAX PMC6643028__F1 GPCR signaling SHH RHO MTOR CDC42 PMC6313651__F1 Gut Microbiota, Fusobacteria, and Colorectal Cancer AHR TIGIT PMC5237710__F2 PI3K/Akt/mTOR pathway involved in tumorigenesis and metastasis BAD GSK3B CCND1 PTEN EIF4E PMC3368076__F6 Proposed mechanisms of leptin and glucocorticoid stress hormones in the GSK3B/Beta-catenin signaling pathway GSK3B STAT3 PMC10886467__F1 Relevant signaling pathway potentially being involved in the pathogenesis of polycystic kidney disease (PKD) and/or chronic kidney disease (CKD) RICTOR PTEN MTOR PMC3832598__F7 CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth MDM2 PMC3399969__F5 State-of-the-science: An update on renal cell carcinoma TSC2 TSC1 GSK3B RHEB PMC7147542__F2 Sonic hedgehog (SHH) pathway SUFU SHH SMO PMC9532747__F1 MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy AHR PLA2R1 PAH PMC12133616__F5 Stepwise presentation of the NF-kB signaling pathway RPS3 TNF PMC6713153__F2 Signalling pathway induced by ManLAM MYD88 TLR1 PMC7136098__F2 Signaling options initiated via wnt5a and the concluded outcome DAAM1 NFATC1 MSC ROR2 RHO PMC8522911__F1 Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies TLR5 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 PMC10571545__F5 TF–FVIIa–driven PAR2 activation triggers EV generation from human TNBC cells, which promotes EMT in non–metastatic breast cancer cells, leading to the induction of proliferation, migration, invasion, and anti–apoptosis PTEN CDH2 PMC8367394__F12 PPAR signaling pathway regulated by high the concentration of ciglitazone UBC PLTP UCP1 AQP7 LPL PMC7136098__F1 Canonical and noncanonical signaling options initiated via wnt3a and the concluded outcome DAAM1 WNT3A NFATC1 APC MSC LRP5 LRP6 RHO PMC3381650__F3 Signaling Networks of the Herpesvirus Entry Mediator (TNFRSF14) in Immune Regulation APC CD160 GRB2 BTLA PMC6317263__F2 Milk exosomes and allergy prevention ITK IL2 SOCS1 DKFZp781O1323 FOXP3 PMC3109223__F1 MTOR signaling pathway TSC2 TSC1 PTEN EIF4E RHEB PMC5612430__F1 Choline and methyl group metabolism and its relation to DNA methylation and influence on regulation of gene expression: a simplified diagram HEL-S-61p ChAT MTR MAT1A CHDH PMC4174543__F3 Activated STING in a Vascular and Pulmonary Syndrome TBK1 CGAS STAT2 IRF3 TYK2 JAK1 PMC10570830__F2 PIFs are the key regulators of skotomorphogenesis DET1 BIN2 DDB1 RFWD2 PMC4958499__F1 Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria PC TAZ PSD PEMT PMC6953096__F4 Representation of DEGs in major signal transduction pathways, in 5a treated cells EPO RHO POR MTOR PMC3866156__F1 Proposed mechanisms of aspirin, the single nucleotide polymorphism rs6983267, and their interaction on the WNT/CTNNB1 pathway COX2 APC GSK3B MYC CCND1 TCF7L2 PMC9028943__F2 Fate of Leydig Cells in Men with Spermatogenic Failure CYP11A1 CYP17A1 PMC4582105__F3 Defects in ribosomal biogenesis activate p53 and other stress-response mechanisms MYC MDM2 POLL POLI PMC8301837__F3 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells PAK1 TFEB RAC1 SENP3 PMC8301837__F2 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells PAK1 NOTCH1 SOX10 PMC6707613__F9 Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers TNF IRS1 PMC3482395__F2 Canonical biogenesis pathway and mechanisms of miRNA deregulation DGCR8 MYC DROSHA PMC9164068__F6 Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes SORCS2 CEMIP SOST NLGN1 RHOV LPA NDUFV3 RAB15 PCSK9 CFH PPP1R3E CCNB1 APP THBS1 XB GPNMB VEGFA THBS4 HLA-DRB1 LEPROT PTPRF ZNF207 HLA-DOA CCDC80 CYR61 HLA-DPB1 PPP3R1 HLA-DRB5 FIG4 OXTR HLA-DRB4 PMC7376433__F1 Molecular pathways involved in hereditary cancer risk CHEK2 NF1 PALB2 ATM MSH6 BARD1 RAD50 MSH2 MTOR MRE11A PMS2 PMC6406288__F3 Consequences of indoleamine 2,3 dioxygenase (IDO) overexpression on the antitumoral immune response KIT AHR ETV4 IFNG PMC7343507__F7 The regulatory role of miR-9 and miR-29a in DPN HEL-S-11 SHH ISL1 PMC3074148__F5 Schematic representation of the two degradation pathways followed by MicA RNASE3 RNASE2 MICA PMC9269291__F5 Potentilla paradoxa Nutt. Ethanol Extract Exhibits Anti-Inflammatory Effects by Suppression of the Src/NFKB Signaling Pathway TLR4 SRC MYD88 PMC8773732__F1 Macrophage Involvement in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Comprehensive, Short Review STAT1 NLRP3 TLR4 SOCS3 TRAF6 RHO TNF IL1B SOCS1 IFNG PMC8657824__F1 The Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens TRPV4 SET OSR1 TRPV1 PMC4822134__F2 Ubiquitin regulation of TLR signaling TBK1 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 PELI1 MAP3K7IP1 TLR3 TLR4 RELA TRAF2 TAB3 PMC151358__F5 JNK-dependent apoptosis signaling pathway STS BMF HTRA2 BAX PMC7007115__F2 Dietary Restriction TSC2 TSC1 IGF1 NR1C1 RHEB PMC4822134__F1 Main signaling pathways of PRRs TBK1 CGAS TLR5 TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 NOD2 TLR3 TLR8 TLR7 TLR4 TRAF5 TRAF2 TIRAP MAVS TAB3 PMC7175140__F6 TGFB non-SMAD signaling pathways SMURF2 GRB2 SMAD6 TRAF6 ARHA RAC1 SMURF1 TF TRAF4 CDC42 STAT3 PMC7175140__F3 TGFB/SMAD signaling pathway SMAD2 SMAD4 TF PMC8695973__F2 Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System DMRTA2 EMX2 ASCL1 FOXG1 DMRTA1 GSX2 DMRT3 PMC7398577__F3 Viral miR-mediated evasion of adaptive immune responses ERAP1 MICB IFI30 MICA CCL5 CXCL11 PMC7398577__F2 Viral miR-mediated suppression of host innate immune pathways TBK1 CD14 SOCS3 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 IL6R TLR3 TLR8 TLR7 TLR4 TIRAP MAVS STAT3 TAB3 PMC8935981__F8 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches TH PMC3527608__F6 Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms BAD BCL2 GIP FADD BAX PMC8935981__F7 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches MAP3K1 MAPK12 ATM SETDB1 MAPK14 MAP2K3 RAN ATR SUMO1 PMC8935981__F9 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches SCD HP ACACA CREM FASN PMC2833108__F7 TNFSFR and NFKB signaling activation during macrophage activation: CpG late responses CASP6 TRADD FOS TRAF3 TRAF6 MYD88 TNF MAP3K7IP1 CASP3 COX2 TRAF1 CASP9 CD40 CAD JUN CASP8 FADD PMC8268514__F1 Review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations BAD MDM2 GRB2 SRC PTEN RAC1 MTOR CDC42 PMC2833108__F6 Sonic Hedgehog, Wnt and TGFB signaling pathway gene expression in CpG late treated macrophages [; ; ; ], see discussion NCAM2 SMAD2 APC GSK3B SHH BMP7 SMO PMC7052372__F2 Innate immune receptors present in cholangiocytes NLRP3 TLR4 IRAK1 IRF3 IRAK4 MYD88 TLR3 MAVS PMC3241960__F5 Sarcolemmal actin assembly and nuclear signaling RHO MAL PMC9694420__F1 PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative BTK PI3 PTEN PMC8348432__F8 Trans-(−)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines? CCNB1 RALA CCND1 CDK4 CDK6 PMC9446754__F5 CD47 as a promising therapeutic target in oncology CD47 MIOS BNIP3 PMC3624606__F1 Oncogenes and tumor suppressor modulate metabolic reprograming in cancer cells TIGAR MYC PTEN GLS PMC6754502__F5 Broiler thymus predicted to have less cell migration in response to the Thermoneutral + LPS treatment compared to Fayoumi DMBT1 S1PR3 ENG CSF1 RHOB PMC4405775__F1 Dependence on signaling pathways based upon tumor suppressor status PI3 SRC ARHA STAT3 PMC5118777__F3 Schematic indicating the role of cellular and EBV miRNAs in EBV latency and reactivation HIVEP2 ZEB2 CEBPB PMC3520003__F1 Simplified summary of the role of ATGL in macrophages.FFAs which are taken up by macrophages are incorporated into TGs (and cholesteryl esters) LPL ARHA RAC1 TG CDC42 PMC10905161__F2 Nrf2/Keap1 signaling pathway ULK1 GCLM KEAP1 GCLC RBX1 HMOX1 MTHFD2 NQO1 BACH1 HEL-S-26 CALCOCO2 MARCO CD36 PMC3779571__F1 Chondrocyte gene network of CSGalNAcT-1 was classified as glycan biosynthesis and metabolism and functional pathway RELA UST CHPF LEPROT MGAT2 PMC6027307__F1 Noncanonical NFKB signaling pathway TRAF3 RELB CD40 TRAF2 PMC7304783__F6 Possible mechanism associated with the tumor-suppressing effect of Romidepsin in DEN-induced HCC mouse model BAD CYLD CCND1 LRP6 PTEN DKK1 PMC11600033__F12 HA/PEI-RH NYPs for UC treatment NPS CD44 MYD88 PMC4422447__F1 Angiotensin II, transforming growth factorB, and Smad signaling pathways SMAD2 SMAD4 PMC5783849__F9 TIPE1 and Wnt/beta‐catenin signalling pathway in gastric cancer APC LRP5 LRP6 PMC9150370__F2 Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms NLRP3 GSK3B SIRT3 PMC6374752__F1 Tryptophan-kynurenine pathway and major functional consequences in the context of GBM growth IDO1 IDO2 PMC8944478__F6 Identification and Molecular Analysis of m6A-circRNAs from Cashmere Goat Reveal Their Integrated Regulatory Network and Putative Functions in Secondary Hair Follicle during Anagen Stage BAMBI BRAF ATF2 EFNB2 PPP3CC ARHGEF12 TGFBR2 CREB1 PTEN ITGA2 DCN BMPR2 AHR HOXD10 GNG2 LDLR CCND1 REST CAMK2D SKIL PITX2 BMP2 DLG2 APC VEGFA FGFR3 TCF7L2 ITGB1 SDC2 WWTR1 PLCB1 SMAD9 PLCB4 WNT3 LEF1 EP300 CXCL12 HEL-S-93 DKFZp781O1323 FRMD6 CAMKK2 AKT3 PMC5831768__F2 Non-canonical Shh signaling in commissural axon guidance HHIP BOC GPC1 SHH SMO PMC3238080__F2 Regulation of intracellular signaling by antiepileptics and modulators of glutamate, acetylcholine, and melatonin systems EEF2 NACA BDNF PMC8831078__F2 Ubiquitination of AMPA receptor subunits UBE2D1 USP46 HEL-S-71 RNF167 APC MDM2 PMC11206339__F1 Common synthesis pathway for testosterone from cholesterol and its subsequent conversion into estrogenic and androgenic active metabolites HSD3B1 CYP11A1 HSD17B3 CYP17A1 PMC5321522__F1 Clinical imaging of cancer metabolism TIGAR F2 GLS PMC4134348__F1 Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization TH TLR4 IRF3 IRAK4 TNF TIRAP PMC8369426__F2 Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders PINK1 MFN2 ULK1 FUNDC1 BNIP3 PGAM5 PARL OPA1 PMC8010610__F1 RAS Signalling Pathway (90% of JMML cases involve mutations in the RAS pathway): N/KRAS proteins (in Pink) alternate between “ACTIVE” and “INACTIVE” states NF1 GAB2 GRB2 PTPN11 MTOR PMC9535022__F3 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials KEAP1 SLC3A2 PMC9535022__F2 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials FGFR1 CDK2 EGFR MDM2 CDK4 PTEN PMC9535022__F4 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials ME2 NSD3 SOX2 SET RBBP4 MAX RBBP7 EZH2 ME3 MTOR FBXW7 SUZ12 PMC9535022__F6 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials IL3 CXCL10 CXCL9 IL2 CDK4 SPOP PTEN EZH2 FZR1 PMC6808435__F10 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida PMC4511781__F1 Insulin and IGF-1 signaling in gray mouse lemursIR and IGF-IR share a similar signaling pathway which invokes downstream changes in two main branches – the mitogenic pathway (Ras/Raf/MEK/ERK) and the metabolic pathway (PI3K/Akt) TSC2 TSC1 IGF1R IGF1 GSK3B PTEN RPS6 MTOR IRS1 PMC6025294__F2A JMY in p53 Regulation ATM JMY MDM2 STRAP PMC6149912__F1 Inhibition of DDR1-BCR signaling by nilotinib DDR1 BCR FOS MYC CD44 CCND1 GPR49 JUN PMC5165017__F1 Working Hypothesis of mechanotransduction in EC cells PIEZO2 PMC7462039__F2 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells ALK SMAD2 VTN TGFBR2 VEGFA SMAD4 CDH2 SMAD1 DKFZp781O1323 PMC7462039__F1 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells EGFR RHO SP1 MTOR FOXO1 PMC3933348__F1 Overview of tamoxifen metabolism pathway and the main enzymes involved CYP2B6 CYP2C9 CYP2C19 PMC8664518__F1 Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective NLRP3 PMC6491677__F1 Metacore™ map showing the signaling context of the genes contained in the “Vascular endothelial cell damage in SLE” pathway HMGB1 HGF VEGFA CCL2 HEL-S-100n TNF TRAF2 PMC10743522__F3 The signaling pathways regulated by phase separation during development MYC BMP4 PMC1087795__F1 Schematic depiction of the S PC PSD2 GPD2 GPD1 PMC9524038__F2 Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption NELL1 RUNX2 APC PMC3726950__F2 Regulation of autophagy pathways and targets for modulating autophagy by drugs/compounds HEL-S-11 EGFR INS MTOR RHEB PMC7915952__F1 Canonical pathway of microRNA (miRNA) processing AGO2 DGCR8 DROSHA PMC7225923__F2 Cancer cell dormancy VTN POSTN VEGFA BMP7 TNF MTOR PMC3193409__F4 Expanding role of ubiquitination in protein kinase activation in diverse NFKB pathways TBK1 BCL10 ATM TRAF3 TRAF6 IRF3 MAP3K7IP1 TRIM25 TRAF2 MAVS TAB3 PMC9520190__F3 Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma IGF1R IGF1 IGF2 GRB2 PTEN IRS1 PMC7546851__F1 Neutrophils in TME ELF2 CXCL1 HGF CXCL5 CXCL2 EIF4E MMP12 CXCR4 MSC BCL2 MCL1 TGFA STAT3 PMC2845723__F2 The bile salt synthetic pathway CYP27A1 CYP7A1 HSD3B7 PMC5069771__F2 Genes upregulated after RSV infection DGIC CMPK2 CXCL8 CCL7 CCL5 PFDN5 OSMR IFNG OAS3 FCER1A NR1i1 HEL-S-11 CD177 DEFA1B FAT10 NOS2 CXCL11 IRF7 STAT2 OLFM4 LCN2 HEL110 TNF HLA-B IL15 TMC5 MUC5AC MS4A6A HEL-S-72p TF MPO GNLY IFITM3 DEFA4 ALOX15 ANXA3 IFIT5 CEACAM6 MX2 MX1 ISG15 OAS1 GBP1 OAS2 CHI3L1 PSMB8 IL10 LAMP3 IRGM TNLG7A NFKBIA CEACAM8 HP KLRD1 TFF2 KLRB1 ALYREF GMPR IL20 GBP4 LGALS9 TSPAN8 ALAS2 EIF2AK2 MYD88 RTP4 SERPINA3 IFITM1 USP18 XRCC5 OASL LAP3 SERPING1 NMI PSMB9 AIM2 CCL8 RSAD2 HBD AIF1 ATF3 CCL4 IL18BP LMNA ISG20 EPSTI1 HELZ2 CXCL9 IFIT1 HEL-S-62p HLA-G FCGR1A DHX58 BATF2 SCGB1A1 IFNA13 GBP2 LILRB4 PRF1 ELANE JUN ERAF CD14 SAMD9L MMP9 S100A12 CXCL2 IL6 OTOF RTN1 PMC9504325__F1 Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies DEFB4B NOD1 HEL-S-130P PMC11906358__F5 Balancing dopamine levels by clock components TH CRY1 MAOA PER2 PMC8426673__F1 Lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses ACE2 ADAM17 PMC11906358__F4 Molecular model of light-induced signalling pathways for clock phase shifting DUSP4 FOS GEM CDK5 CRTC1 JUN PER2 SIK1 PER1 PMC8892088__F1 Metabolic regulation of ferroptosis in the tumor microenvironment GPX4 SLC7A11 SLC3A2 PMC5068231__F7 Cpb1–C3–C3aR pathway amplifying p38 MAPK signaling downstream of TLR4 and Ifnar activation in macrophages HEL-S-62p TLR4 CPB1 IL6 NOS2 TNF IFNG PMC7385189__F2 Primary resistance CXCL10 EGFR CXCL9 CXCL8 PTEN CTLA4 LAG3 TOX B2M MTOR PMC8892088__F4 Metabolic regulation of ferroptosis in the tumor microenvironment STAT1 GPX4 SLC7A11 SLC3A2 IFNG PMC8892088__F5 Metabolic regulation of ferroptosis in the tumor microenvironment GPX4 MITA AGER CD36 PMC4984446__F1 The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease RPL11 MDM2 RPL5 PAK1IP1 PMC7465818__F1 Canonical NFKB pathway can be activated via multiple different ligand/receptor interactions BCR RELB CD40 PMC3956512__F1 The unfolded protein response (UPR) pathway in Cryptococcus ATF4 EIF2A XBP1 PMC7352466__F2 Biological effect of PARPi on cancer cells TBK1 CGAS CXCL10 IRF3 CCL5 PMC3569094__F1 Novel therapeutic approaches for overcoming limitations in the gemcitabine pathway CDA RRM1 RRM2 PMC11764055__F2 Mechano-transduction pathways regulating YAP/TAZ activity NF2 LATS1 MOB1A MOBKL1A LATS2 PMC8334851__F2 Impacts of Immunometabolism on Male Reproduction CD40 CD80 TNF FOXP3 PMC3331705__F1 Tumor suppressors and oncogenes in the Wnt pathway TANK APC LRP5 LRP6 PORCN BCL9 PMC3701596__F3 Sleep specific effects on protein processing and the unfolded protein response UBA2 COPE HP ATF4 SVIP VIP PMC6789122__F7 Proposed model for the role of RarA in adrenocortical development RARA LEF1 TCF3 WNT4 VEGFA RXRA CYP11B2 PMC5122440__F2 Sweet trap in tumors: aerobic glycolysis and potential targets for therapy TIGAR TSC2 TSC1 PTEN MTOR HEL-S-133P PMC3613825__F8 Proposed model of regulation of pro-apoptotic signaling pathway by miR-128 MDM2 IGFBP5 SIRT1 PMC3775871__F1 Epigenetic Regulation of SOX9 by the NFKB Signaling Pathway in Pancreatic Cancer Stem Cells EGF NGF HEL-S-71 RELB PLCG2 MAP3K7IP1 LTA RELA CD40 TGFA CP TIRAP TAB3 PMC3636549__F2 HEDGEHOG SIGNALING IN CHOLANGIOCYTES HHIP SMO PMC4746688__F8 A Novel Pathway for Triacylglycerol Biosynthesis Is Responsible for the Accumulation of Massive Quantities of Glycerolipids in the Surface Wax of Bayberry (Myrica pensylvanica) Fruit LPA PAH PMC9534503__F6 Species unique MEGENA modules HEL-S-166mP HLA-G MYBL2 ANXA11 CTSS VAT1 TUBB AKT1S1 HCTP4 SPNS1 RBM34 ZCCHC8 ECT2 IQCC FGD2 NT5DC2 ZNF74 VPS39 KPNA2 MCM10 B2M FANCE PMC6534790__F2 Coagulation factors and their connection to monocyte activation F2 VWF GP1BA PMC7230958__F1 Summary of the metabolic pathway for n-6 and n-3 polyunsaturated fatty acids ADA TNLG7C GLA PMC11769975__F2 Fusobacterium nucleatum reshapes the tumor milieu in CRC cells and immune cells [This figure was created using MedPeer (www EGF CXCL2 TIGIT TNF ARG1 CCL3 PMC11769975__F1 Mechanisms by which Fusobacterium nucleatum may contribute to colorectal carcinogenesis [This figure was created using MedPeer (www PAK1 TLR4 WNT7A MYC CCND1 WNT9A PTEN MYD88 TNF WNT7B PMC6337850__F6 A working model: N-Myc differentially regulating miR-421/ATM pathway contributes to ADT resistance and Enzalutamide resistance development of prostate cancer ATM EZH2 ELL PMC6823248__F5 HDAC6 inhibition repressed B cell signaling pathways in NZB/NZW mice FOS CREB1 PTEN BLK CD81 DAPP1 FYN TLR4 BCL10 BASH LYN CD180 CD40 IL4 JUN PMC9687725__F6 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media CANX PMC5733345__F1 Principal pathways of cell death RIPK1 BAD RIPK3 IL1B FADD MLKL BAX PMC12204001__F1 Molecular mechanisms of cGAS-STING pathway activation TBK1 CGAS IRF3 PMC11769975__F5 Apoptotic effect and immune invasion of Porphyromonas gingivalis in OSCC [This figure was created using MedPeer (www NLRP3 BAD STAT3 BAX PMC12204001__F3 Protumor role of cGAS-STING pathway TBK1 CGAS IRF3 PMC4139969__F3 Role and targeting of Aurora kinases in head and neck cancer FOXM1 TDRD7 MBD3 ANKZF1 NUP107 KLHL9 KLHL13 NCL PMF1 ZW10 AJUBA CENPE HCTP4 BRCA1 AURKA AURKB NFKBIA PAK1 SMC2 SMC4 C13orf34 PPP2R5D TBL3 MYLK CLASP1 NSUN2 PMC12204001__F2 Anti-tumor role of cGAS-STING pathway CGAS PTMS MICB CXCL10 MICA CXCL11 PMC11769975__F3 Possible molecular mechanisms of Fusobacterium nucleatum in tumor progression [This figure was created using MedPeer (www NLRP3 TLR4 BIRC3 RIPK2 PMC8460903__F5 Mechanotransduction Regulates Reprogramming Enhancement in Adherent 3D Keratocyte Cultures SMAD2 RHO SMAD1 DKFZp781O1323 PMC3750319__F2 Canonical, non-canonical and the atypical NFKB signaling pathway ATM CD40 TNF PMC8502110__F5 MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in Gamma-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease BCAT1 ARHGEF12 ARHA PTEN MTOR PMC9687725__F3 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media MYH2 CAMK2A PMC8647069__F8 COVID-19 with obliterating endothelialitis associated with complement activation and accumulation of C5aR1-expressing macrophages around vessels CD163 ACE2 CD68 PMC9687725__F2 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media EGF GPR171 MMP9 GNG7 RRAS GIP BOK PMC3750319__F5 Crosstalk of the canonical NFKB pathway with other signaling processes CYLD VCAM1 ERG RELA IL6 STAT3 PMC2772702__F6 The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV MTOR PMC5908099__F4 Signalling interaction of the death receptor pathway and mitochondrial pathway PIG59 PYGL CPD PMC7958858__F2 Signaling pathways involved in TJ formation and modulation CD14 IRAK1 ATF2 RELA EGFR GRB2 TRAF6 ARHA IRAK4 PMC8285369__F1 Melatonin interferes with COVID-19 at several distinct ROS-related steps MPO IL6 TNF PMC4450212__F4 Significant signaling pathway networks mined from phosphotyrosine-containing proteins in a glioblastoma tissue RAB37 HPS1 ARAP1 GPR176 SYNGR3 PTPRS PLXND1 PLEK2 PSD3 CEP192 ACTBL2 NLRC3 HEL-S-281 HEXA ENO1 DCHS1 ZNF569 PS1TP5BP1 HEL25 MRPS33 DNAJC25 RNASE7 HOXA1 EFR3A RABL2B SPATA2L RBM12B CHI3L2 CEP85 PXMP2 LDHAL6A PMC11865073__F5 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 10 months TBK1 TH CX3CR1 CX3CL1 WNT1 TICAM2 GSK3B CCL5 IL1R1 CCL2 MYD88 HMOX1 FZD1 IFNG IL18 ACVR2B BIRC3 GDNF IL4 GJB1 HMGB1 SNCA PTGS2 MMP9 IRF3 IL6 TNF CYBB TYROBP NTF3 RET GABBR2 BCL2 CD40 SYK CD80 IRAK3 PYCARD TIRAP PMC6381083__F9 Canonical and non-canonical NFKB pathway RELA TRAF3 RELB CD40 MYD88 TRAF2 LTBR PMC11865073__F3 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 7 months BACE1 NGF CX3CR1 CX3CL1 WNT1 TICAM2 GSK3B TRAF3 CCL5 IRAK4 CCL2 SLC6A11 HMOX1 IFNG MMP3 IL18 TLR7 CRP IL4 GJB1 CREB5 HMGB1 SNCA IL10 IRF7 PTGS2 MMP9 CXCL10 NFE2L2 IRF3 GABRB2 TNF NTF3 GABRB1 ACVR1B GRIN2B BCL2 CD40 SYK CXCL12 PYCARD PMC6162708__F1 Canonical and DNA damage-induced NFKB signalling pathways BTC BCL10 BCR TRADD ATM BASH ZAP70 TRAF6 ATR PMC3575708__F8 Model for Ctip2 functions in the proliferation and differentiation of epidermal keratinocytes EGF EGFR NOTCH1 PMC2574996__F15 Our difficulty in suppressing epimerization at the bis-benzylic stereocenter bearing the ester in the azide displacement led us to pursue an alternate route to amurensinine via intermediates with attenuated acidity at the bis-benzylic carbon () CS ATM PMC2574996__F12 We then examined the Pd-catalyzed oxidative kinetic resolution of hydroxyester (±)-15 CS ATM PMC4754450__F1 Abbreviated pathway for the biosynthesis and metabolism of Orn in plants in connection to polyamines, amino acids, TCA cycle metabolites, and alkaloids NAGK DAO PRODH OTC NAGS PMC7310007__F2 cGAS-STING pathway TBK1 CGAS IRF3 PMC11121637__F1 Schematic representation illustrates the role of miRNAs in the regulation of FOSL1 FOSL1 PMC2948329__F2 TSC1/2 integrates multiple signals to control cell growth and proliferation TSC1 CDK2 RHEB PMC11121637__F4 FOSL1 in promoting drug resistance and radio resistance ITGB4 FOSL1 DUSP7 PMC5989100__F2 Major signalling pathways involved in the control of skeletal muscle hypertrophy and mitochondrial biogenesis TSC2 TSC1 IGF1 MTOR RHEB PMC4848843__F2 Regulation of lipid metabolism by BAF60a and BAF60c in periportal and perivenous hepatocytes, respectively, under the control of nutritional and hormonal signals USF1 NR1C1 SIRT1 PMC7330533__F2 Network pharmacology of targets of anemoside B4 against pneumonia CASP3 NFKB1 CASP9 TNF TGFB1 CASP8 PMC7330533__F8 Schematic of anemoside B4’s anti-inflammatory mechanism IL16 TLR4 MYD88 PMC8120178__F2 Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach BAD GSK3B MDM2 MTOR PMC10669348__F3 Schematic and simplified overview of the intracellular transduction cascades induced by 5-HT2AR TrkB and Sig-1R receptor activation by psychedelics GRB2 MTOR BDNF PMC8661100__F3 Evidence of myomiR regulation of the pentose phosphate pathway during mechanical load‐induced hypertrophy PSAT1 SHMT1 SFXN1 PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH SLC38A1 PMC10142331__F2 SFTSV mediates cell cycle, apoptosis, and the cGAS-STING pathway to achieve immune escape TBK1 CGAS MAX CDC2 PMC10142331__F1 Mechanisms by which SFTS inhibits key immune signalling pathways and promotes inflammation NLRP3 STAT2 IRF7 IRF9 TRIM21 IRF3 TRIM25 MAVS BAX PMC4499842__F7 UCB-MSC therapy is curative for IC bladder EGF IGF2 FGF16 PMC11606877__F3 Anticancer role of RES against NMSC: Focusing on oxidative stress, cellular, and molecular mechanisms TNF PMC8617551__F2 Antagonism of interferon signalling by SARS-CoV-2 and related coronaviruses TBK1 IRF7 ATF2 TRAF6 IRF3 IFNAR2 IFNAR1 TRIM25 RNASEL STAT1 TYK2 JAK1 JUN MAVS PMC7299535__F7 Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity GALNS DKK3 GATA3 PMC6005202__F2 Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology HEL-S-62p C6 PMC4442140__F3 Results from validation screens for Listeria infection PIK3R1 FGD4 BACE1 CLTA MYL2 HEL-S-15 MYC PDLIM7 TLN1 RPL35A MTOR VIP PI3 FAU PERP MYO6 DIAPH2 NCKAP1 FURIN OCRL CYFIP1 RAB35 LIMK2 LIMK1 ARHA RAC1 ITGB1 RPL8 CBL RAB10 COPB2 ARPC2 TRAT1 GRB2 CLTC RSPO4 ACTR3 CDC42 PMC3635523__F7 Schematic model put forward the potential role of P4HB at different GBM cell states to TMZ treatment ATF4 EIF2A BAX PMC9589302__F6 Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NFKB pathway and protecting the intestinal barrier TLR4 IRAK1 IRAK4 PMC5850280__F1 Wnt activity is necessary for heart development and becomes very low in the adult heart MSC WIF1 PMC9107641__F2 Metabolic engineering of Clostridium ljungdahlii for the production of hexanol and butanol from CO2 and H2 HBD POR COCH CCAR1 PMC6984455__F1 Brief mechanisms of Ub-dependent and Ub-independent mitophagy ATG16L1 PARK2 BCL2L13 BNIP3L BNIP3 PMC4550852__F7 FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes AOX1 MTOR HEL-S-104 PMC3023586__F1 Host-cell signalling induced by EPEC Tir FYN TEC RAC1 PMC9021824__F5 miR-1908 Dysregulation in Human Cancers SMAD2 LDLR SMAD4 SKI TGFBI PMC9021824__F2 miR-1908 Dysregulation in Human Cancers NKIRAS2 JUND PTEN SFRS3 MEF2C PMC1951772__F8 PI3K activation by eIF2A kinases RICTOR EIF2A EIF4E MTOR PMC7217141__F2 Summary of the processes thought to be involved in thoracic aortopathy development TIMP1 COL3A1 FBN1 PRKG1 MYLK PMC3490280__F2 Recipient T-lymphocytes govern Mesenchymal stem cell (MSC)-based bone regeneration via IFNG and TNFA RUNX2 MSC SMAD6 PMC7912581__F8 Complex mechanism of FASIS and (B) GPR40 receptor part KY NOX4 GIP TRPM5 TG VIP GPR119 SIRT3 TRPC1 TRPC3 PYY TRPM2 ORAI1 STIM1 PMC4893201__F1 Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes HEL-S-26 NAMPT SIRT6 SIRT1 PMC2543934__F5 PPARG in Type 1/Type 2 T (NK) cell differentiation STAT1 STAT4 IFNGR2 IL4 GATA3 PMC11669335__F3 Canonical and non-canonical inflammasome pathways in pyroptosis NLRP3 IL1B GSDMD PMC5440090__F2 Anti-tumor immune response through CTLA-4 and PD-1 pathway blockade, and T-cell signaling in the treatment of melanoma MTCL1 HEL-S-92n PMC11669335__F2 Extrinsic and intrinsic apoptotic pathways APAF1 FADD BAX PMC7117992__F2 Key longevity-regulating pathway proteins whose functions may be altered or enhanced by differential PTMs/proteoforms in long-lived species TSC2 TSC1 SIRT6 PARP1 MTOR DKFZp686F0183 SIRT1 INSR PMC9315936__F4 JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies CRLF2 TSLP PMC7912581__F2 New paradigm in the mechanism of GSIS in the context of the regulation of insulin secretion ME1 KY SST NOX4 GIP TRPM5 SNAP25 VIP GLP1R HEL-S-26 TRPC1 PC PYY TRPM2 ORAI1 STIM1 PMC8923340__F3 COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines TBK1 IRF7 TRAF3 CXCL8 TRAF6 RIGI IRF3 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 NRP1 CXCL9 FURIN IRAK3 ACE2 TMPRSS2 PMC7829997__F2 Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay IDO1 AHR PMC11669335__F5 Classical autophagy pathway ULK1 ATG16L1 ATG12 ATG3 ATG101 ATG10 PMC11669335__F4 Necroptosis pathway RIPK1 TRADD RIPK3 TNF TRAF2 FADD MLKL PMC3778193__F6 Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NFKB activation TLR4 BMP2 NOTCH1 PMC8471547__F6 SMAD4 Feedback Activates the Canonical TGFB Family Signaling Pathways BMPR2 ACVR1B TGFBR2 SMAD4 CREB1 SP1 TF PMC3141288__F3 Roles of NFKB-mediated inflammatory pathway in cellular transformation, cancer survival, proliferation, invasion, angiogenesis and metastasis COX2 VCAM1 CXCR4 CCND1 TNF PMC3691323__F6 Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain AKAP8 APC INCENP HEL-S-66 CDC2 PMC8431051__F2 Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer IDO1 ERG IMPACT CXCL8 PTEN CCL2 CSF1 FOXP3 PMC8238692__F1 Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress TLR4 CXCR4 NOD2 CD69 PMC7779530__F2 TGFB signaling HEL-S-28 SMAD2 SMAD4 PMC6161786__F2 Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy IRAK1 TRAF6 MAP3K7IP1 PMC6721808__F7 Simplified model of fatty acid (FA) metabolism PML FASN CD36 PMC4977549__F1 ‘Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients’ CCR2 CHUK IRAK2 GSK3B NRAS MAPK14 MYD88 STAT1 COL11A2 TLR4 BCL10 F2 FURIN MAPKAPK2 ITGB3 NFATC1 FOS MAPK7 ARHA TNFRSF11B NFATC3 CBL RELA GNAI3 LBP TNFRSF18 BCL2 ITGAV GNAS RAF1 SOCS1 CYCS STAT3 PMC11831195__F3 Molecular docking of PD and targets MMP3 PTGS2 HMOX1 STAT3 PMC6721808__F1 Simplified scheme of the cellular metabolism pathways important for AML pathophysiology SLC7A5 MTOR PMC7281175__F2 Metabolic pathways in hepatocarcinogenesis GPX4 FACL4 CYP7B1 TG BAAT HMGCR HSD3B7 CYP27A1 CYP8B1 MVD ABAT DHCR7 HEL-S-64p SUCLA2 ACLY PMC11591849__F3 The diverse mechanisms through which anti-diabetic pharmacotherapy may affect tumor microenvironment dynamics NLRP3 CXCL10 CXCL8 CCL2 STAT3 PMC11591849__F1 Impact of metformin on cancer-related signaling pathways via AMPK activation TSC2 ULK1 IGF1R GSK3B CCND1 MTOR IRS1 PMC8263695__F1 Targeting the eicosanoid pathway in hepatocellular carcinoma COX2 COX1 PMC10389832__F1 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies TBK1 CGAS IRF3 PMC6141902__F1 The two commonly activated pathways and genetic aberrations involved in thyroid cancer, as well as the targeted therapies studied in thyroid cancer NF1 RET ALK EGFR PTEN MTOR TERT PMC8382522__F9 Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/Beta-Catenin Signaling Pathway APC TNF IL1B PMC7177281__F1 Neurotrophins and their effect on angiogenesis and neurogenesis in the skin EGF IGF1R IGF1 NGF IGF2 EGFR BDNF IGF2R PMC10389832__F4 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies ENPP1 TREX1 PARP1 IRF3 STAT3 PMC7729630__F5 Schematic model illustrating an effect of PEA on CORT-induced depression-like mice model CORT TAAR1 BDNF SYP PMC6836709__F9 Pathways to autoimmunity and autoinflammation in ABIN1[D485N] mice TLR7 IRAK1 IRAK4 MYD88 AK1 TK1 PMC5855695__F1 MicroRNA biosynthesis pathway AGO1 AGO2 DGCR8 AGO4 DROSHA PMC6292306__F2 Serotonin directly increases PTHrP synthesis in the mammary gland and indirectly through regulation of the Hedgehog signaling pathway CASR SHH ORAI1 PMC4671741__F5 Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension MTR CTRL HEL-75 PAH PMC6292306__F1 Calcium movement into the mammary gland regulates maternal calcium homeostasis during lactation PTH1R CASR ORAI1 PMC8593415__F8 Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target TTF2 VLDLR LMO1 SMC2 TYMS MYH7 RRAS2 MTOR RBM20 PMC3731598__F1 An immune synapse and downstream events CD27 TNLG8A BTLA CD40 CTLA4 LAG3 PMC11352355__F2 Cell functions of K6, K16, and K17 STAT1 KRT16 EGFR IL22 AIRE MTOR H2AX HMGN2 IFNG STAT3 PMC11040904__F2 Regulatory pathways governing PD-L1 via phosphorylation and ubiquitination EGF LRRK2 USP2 APC HUWE1 CDK6 RNF125 STT3A STUB1 TMUB1 CMTM6 CDK4 SPOP JAK1 TNFAIP3 CASP8 MIB2 CMTM4 IFIT1 PMC11040904__F4 Regulatory pathways of PD-L1 via deubiquitination TINCR USP2 APC USP9X USP20 HEL-117 USP22 USP51 USP18 PMC11040904__F3 Negative regulatory pathways of PD-L1 mediated by other posttranslational modifications ING4 UFM1 ISG15 MMP7 SETD7 APC MMP9 UFL1 PMC3831322__F5 Scheme illustrating potential mechanisms by which nandrolone reduces bone loss after SCI WNT3A RUNX2 LRP5 ENC1 FZD5 PMC11040904__F6 Positive regulatory pathways of PD-L1 mediated by other posttranslational modifications EGF APC ZDHHC9 HDAC2 ZDHHC3 ARF6 PDIA5 FASN PMC11040904__F5 Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways EGF GLT1D1 STT3A TMUB1 APC B3GNT3 B4GALT1 SEC61G FAT4 PMC5403977__F12 EGF and GLP-2 signaling to attenuate mucosal atrophy in a mouse TPN model EGF IGF1 CCND1 PMC11040904__F7 Posttranslational modification of PD-1 FUT8 CISH FBXO38 LCK MDM2 EIF4E PMC8960869__F8 Mechanism by which HORMAD1 functions to promote the malignant phenotypes of lung cancer cells MMP7 LEF1 APC MMP9 CCND1 PMC6600647__F4 Uncovering the assembly pathway of human ribosomes and its emerging links to disease RPL11 RRS1 RPL5 PMC9504097__F2 Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure NLRP3 TJP1 IL18 PMC3820966__F1 Cellular response to oxidative stress mediating by Beta-adrenergic response and sirtuins involvement GADD45A ADRBK1 BAX PMC9266407__F3 Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses ANAPC2 MYC COCH PMC11586797__F1 Mammalian target of rapamycin signaling pathway and its interaction with EZH2 expression in hepatocellular carcinoma: Mechanisms and implications PTEN EZH2 MTOR PMC7859916__F2 Role of Eps8 in the regulation of the malignant phenotype of a tumour EGF FOXM1 EGFR GSK3B GRB2 CCND1 SRC MTOR STAT3 PMC3783819__F3 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction EGF CXCL1 IGF1R HGF SMAD2 EGFR MYC CD44 IGF1 MMP2 GAB2 RELA GRB2 CCND1 STAT3 PMC3783819__F2 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction FOS GRB2 MTOR JUN PMC9238060__F2 Epigenetic modifications in drug resistance and treatment of breast cancer TDG ME3 PMC9238060__F1 Epigenetic modifications in drug resistance and treatment of breast cancer SMAD2 APC EGFR SMAD4 PMC6299639__F2 Mechanism of HSV evades host immune responses HEL-S-62p TBK1 TRAF3 TRAF6 IRF3 MYD88 TLR3 RNASEL STAT1 RNASE1 EIF2A MAVS IFI16 PMC7585181__F2 Participation of SUMOylation in molecular signalling pathways involved in atherosclerosis RELA SENP2 NR1C1 PMC8397972__F4 Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation FOS MYC MTOR ZMIZ1 SUZ12 PI3 IGF1 MAX PIKFYVE FHL2 GRB2 TXNIP OSR1 EZH2 SP1 NFYA PMC3736728__F2 Folate, Alcohol, and Liver Disease HEL-S-61p PMC11640331__F1 Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies SUFU PTCH1 GLI3 SMO PMC6829497__F1 Canonical Wnt ligands induce two mutually exclusive Dvl2- and Fyn-dependent arms WNT3A LRP5 SRC LRP6 STAT3 PMC6274068__F1 Capsaicin mediates saliva secretion via transient receptor potential vanilloid subtype 1 (TRPV1) AQP5 TRPV1 PMC8951683__F9 Effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway ACAN SMS SOX9 HES1 PMC8649804__F7 Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling IGF1 RUNX2 SMAD2 SMAD4 SMAD1 TF DKFZp781O1323 PMC11941340__F1 Interaction of the WNT pathway, Hippo pathway, and Notch pathway WWC3 WWC1 APC GSK3B LRP5 LRP6 TEAD4 LATS1 LATS2 TEAD2 TEAD3 AXIN1 WWC2 PMC8066746__F3 Schematic model of “Common Pathways Underlying Drug dependence” is an output (FDR p < 0.01) of the Wikipathway functional pathway analysis ADCY1 GRIA3 CREB1 DRD1 DRD2 GRIA2 DRD4 PRKACG PS1TP5BP1 PRKCB RAP1A CAMK4 GRIA4 RAF1 ARAF PMC6204183__F3 Neuropeptide signalling pathway (GO:0007218) enriched by genes that showed higher expression level in the hypothalamus of 3-week-old than 6-week-old cockerels NMU POMC NMB NPY PMCH CGA GHRH PMC7771963__F1 Interconversion of phosphoinositides in eukaryotic cells PI3 FIG4 PTEN OCRL INPP5E PMC3092273__F1 Complementary signaling pathways activated in human cancer cells TSC2 TSC1 IGF1 MYC PTEN MTOR RHEB PMC11669362__F6 Activation profile of the Growth hormone signaling pathway (gene expression via SRF, ELK1, STAT5B, CEBPD, STAT1, STAT3) in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy GHR PTPN6 IRS1 CEBPB PMC4778065__F9 Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases HDAC5 PMC11669362__F8 Activation profile of the Interleukin 10 signaling pathway in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy IL10 CD14 TLR4 SOCS3 ZFP36 TYK2 TIA1 PMC2907165__F1 Type I IFN Signaling IRF9 VAV1 TYK2 IFNAR2 RAC1 JAK1 MTOR IFNAR1 IRS1 CRKL PMC10820555__F3 Study on the Pharmacological Mechanism of Icariin for the Treatment of Alzheimer’s Disease Based on Network Pharmacology and Molecular Docking Techniques TLR4 EPO DAO BIK PFKL TFRC HEL-S-87p HEL-S-133P STAT3 HEL-S-162eP PMC5783486__F4 Network of differentially expressed proteins in KD with CAD and CAA HEL-S-62p C4B_2 ALB PROC LPA C4A CLU IGFALS SERPINC1 C9 HEL-S-78p A2M CFH SERPIND1 F2 SERPING1 SERPINA1 KNG1 APOA2 APOE FGA HRG SET CFB PLG GUGU MBL2 HPR APOB F13B PLTP VTN APOH SRGN PMC6322547__F1 Transcriptomic analysis of axon guidance signaling pathways in liver fibrogenesis BOC RAD1 gdf7 SEMA7A HEL-S-28 FES BMP7 RYK ARHA ROBO2 SLIT2 RHOD FYN PTCH1 SHH SMO RND1 CXCL12 DCC SLIT1 NEK1 CDC42 PMC3430210__F1 TRAIL signaling pathway and mechanisms of TRAIL resistance FADD BAX PMC7458154__F2 Three Examples of Metabolic Transitions Influencing the Activation of Transcriptional Programs That Have an Instrumental Effect on Cell Fate Transitions SMAD2 PMC7397164__F1 Canonical and non-canonical Wnt signaling pathways NLK DAAM1 APC LRP5 LRP6 ARHA RYK RAC1 CDC42 PMC7458154__F1 Connections of Metabolic Pathways with PTM Reactions through Intermediate Metabolites and Impact of Growth Factor Signaling on Modulation of Glucose Metabolism TSC2 TSC1 MYC HIF1A FOXO1 PMC8232639__F1 Insulin in Health and Disease: An Update TSC2 BAD TSC1 GRB2 EIF4E PMC7817532__F2 Toxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells PIK3R1 CAMK2D ATP1A1 FOS GRIA3 ADRB2 ARHA RHO RRAS2 TNF PIK3R3 ATP2B1 CFTR GHRL EP300 GLI3 GRIA4 BDNF JUN CREB5 PMC5035631__F1 Sweet path to metabolic demise: fructose and lipid synthesis ALDOB GYS2 ACACA PKLR GCK KHK MTTP FASN PMC1952636__F9 Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection EGFR SRC HBEGF PMC5452883__F1 Intratumoral synthesis of E2 and its inactivation by sulfate conjugation from circulating steroid hormone precursors in cancer cells STS SULT1E1 HSD17B1 HSD17B2 PMC6959903__F6 MiRNA-mRNA regulatory networks in adenoid cystic carcinoma (ACC) CCNB2 CENPF CDC2 TOP2A PMC8714803__F7 Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic MED25 TH RUTBC1 ICE1 SCRIB MAP3K10 TNK2 TSC2 ABCC1 ATP13A1 ACD JUN ADRBK1 AGAP2 FASN PMC8832142__F1 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis VHL PTH ND4 HEL-S-133P GLS PMC8832142__F2 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis OGA RUNX2 OGT MTOR HEL-S-133P GLS PMC3557298__F4 mRNA-seq Analysis of the Gossypium arboreum transcriptome Reveals Tissue Selective Signaling in Response to Water Stress during Seedling Stage BAK1 BIN2 EBF2 TF PMC3994912__F2 Can Transcriptomics Provide Insight into the Chemopreventive Mechanisms of Complex Mixtures of Phytochemicals in Humans? MAPK14 TRAF3 TRAF6 BMF DIABLO PAX3 PDPK1 TICAM1 IFNG TLR4 ATF4 TRAF2 FADD SUMO1 BAX PMC7662794__F1 Risk factors/loci and associated cellular processes identified by genome wide association studies (GWAS) involved in Alzheimer’s Disease (AD) converge to the proteostasis network SORL1 CD33 PSEN2 PSEN1 BIN1 APP EPHA1 ADAM10 PICALM CR1 CLU PMC3104565__F1 Simplified diagrams for agrin-induced signaling FYN MUSK LRP4 PMC6235774__F1 Signaling reactions induced by thrombopoietin PRKCE BRAF HEL-S-11 TEC POR HRAS MTOR CRK THPO GAA MPL PMC3838875__F4 Cancer Cells Incorporate and Remodel Exogenous Palmitate into Structural and Oncogenic Signaling Lipids PC LPA HEL-S-5 PMC2613484__F3 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways VCAM1 RELB LTBR PMC4972037__F1 Understanding Extranuclear (Nongenomic) Androgen Signaling: What a frog oocyte can tell us about human biology MOS PELP1 EGFR SRC PMC1937523__F3 Comparison between the gene expression profiles and predicted substrate uptake rates PTS DLD GIP CIT MAL GALP PMC8605121__F2 Dysfunction of miR‐802 in tumors FGFR1 SUFU APC EGFR RAB23 SMO PTEN ZNF521 MTOR RAN PMC8605121__F1 Dysfunction of miR‐802 in tumors RUNX3 MAP2K4 FOXM1 MYLIP RAB23 TCF7L2 PTEN ZNF521 MMP21 MTOR BTF3 SRSF9 NKD1 FLOT2 PC ARPP19 CYLD GC UBN2 CDH2 RAN HEL-S-93 TCF4 PMC6469084__F7 Relationship between USP6NL and the pathway CCND1 USP6NL PMC2613484__F7 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways RELB BTLA LTBR PMC8551324__F8 NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer ERBB2 CDK2 ERBB3 EGFR GRB2 HBEGF JAK1 HRAS RAI1 STAT3 PMC10920326__F2 Differential cellular components within the bone marrow microenvironment involved in immune evasion of MM CD14 FGF2 CD40 S100A9 PMC8971914__F1 Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function YTHDF2 YTHDF1 METTL3 AAG1 YTHDC1 ZNF609 PMC6584587__F5 Pathway map for “LRRK2 in neurons in Parkinson’s disease” HEL70 CS LRRK2 AP2A1 GSK3B RAC1 RDX PS1TP5BP1 PMC2788512__F7 Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway LMX1A PITX3 WNT1 MSX1 SHH OTX2 LMX1B FOXA2 PMC9288030__F2 Noncoding RNAs as sensors of tumor microenvironmental stress TNF IL1B PMC3047785__F5 CD28 signaling events BAD FLNA LCK VAV1 GRB2 RAC1 MTOR CDC42 PMC9632440__F7 Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer’s disease BAD PTGS2 GSK3B BCL2 IL6 TNF JUN BAX PMC7601648__F2 Non-canonical NFKB signalling pathway and the role of ubiquitination ZFP91 OTUD7B TRAF3 RELB CD40 TRAF2 PMC2918459__F1 Biosynthetic pathway of ω3 and ω6 polyunsaturated fatty acids (PUFAs) COX2 COX1 FADS2 FADS1 ELOVL2 PMC8930976__F2 Queueing theory model of pentose phosphate pathway HEL-S-304 RPE PMC4885105__F2 Infection cycle of HCV CLDN1 EGFR LDLR NPC1L1 CD81 PMC5145800__F1 Astrocytes and neuronal activity play distinct, cooperative roles in neuronal redox homeostasis MAF GCLM KEAP1 GCLC HEL-75 GCK TXN PMC8074089__F4 Rho Family GTPases and Rho GEFs in Glucose Homeostasis PTEN RAC1 GRB10 IRS1 PMC1819569__F6 The signalling pathways involved in Pam3Cys-induced degranulation and cytokine/chemokine production in human LAD 2, MLMC and BMMC CCL2 TLR1 PMC2658783__F2 The erbB family and the IGF/IGF-1R system IGF1R IGF1 IGF2 TGFA PMC4139483__F1 An Unexpected Journey: Lysine Methylation Across the Proteome SETD6 SMYD2 RELA PMC7044062__F8 Changes in the urea cycle following LPS stimulation with or without DCA pretreatment OTC ADM ASL PMC8599256__F2 Endogenous estrogens—breast cancer and chemoprevention CYP1B1 CYP1A1 CYP1A2 PMC11989623__F2 Main mechanisms of resistance to ET and/or CDK4/6is in advanced ER+/HER2− breast cancer EGFR SMAD4 PTEN LATS1 RB1 MTOR BRCA1 AURKA LATS2 CDK6 CHEK2 NF1 ATM BRCA2 CDK2 CDK4 ATR TF PMC11989623__F1 Complexity of the molecular pathways governing the function of the cyclin-dependent kinases (CDKs) through the cell-division cycle CDK2 MYC CDK4 CDC2 CDK6 PMC9405369__F1 Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases MAF GCLM KEAP1 HMOX1 NQO1 PMC9456568__F2 NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets CCR5 NAMPT TLR4 BRAF MSC PMC2715958__F2 One possible pathway which regulates cell migration in response to strain on fibronectin GSK3B SRC RAC1 PMC2715958__F1 One possible pathway which regulates cell proliferation in response to strain on collagen GSK3B SRC RAC1 PMC6163134__F2 Proposed signaling pathways in the development of hepatic portal hypertension ARHA RHO HLF PMC5733019__F8 GHK on pulmonary fibrosis IGF1 BLM MMP9 PMC5542379__F2 miR-206/133b Cluster: A Weapon against Lung Cancer? SAMD3 BCL2 TRIB2 GPD2 HEL107 PMC5542379__F1 miR-133b/206 Associates with Various Genes Mediating NSCLC Cell Migration and InvasionmiR-206 promoted lung cancer cell apoptosis by targeting c-Met and Bcl2, as well as governed EGFR, MET, and its downstream phosphorylation of ERK1/2 and AKT SAMD3 EGFR BCL2 MCL1 SOX9 BCL2L2 PMC5404780__F2 Mechanism of action of various Hedgehog pathway inhibitors TLR8 TLR7 SMO PMC9682161__F2 Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling? APC EGFR GSK3B LRP5 GRB2 SRC LRP6 MTOR PMC5837124__F3 Various strategies to target Myc PLK1 MAX MYC CDK9 AURKA CDK7 BRD4 PMC8687853__F5 H2A.X Phosphorylation in Oxidative Stress and Risk Assessment in Plasma Medicine BAD ATRIP SSB BCL2 CAD PPIC BAX PMC11200984__F6 Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies IGF1R SMAD2 EGFR ABCC1 SMAD4 PARP1 PTEN CDC2 MTOR ROS1 STAT3 BAX PMC5295490__F4 B3AR signaling activation in cardiomyocytes PLN HEL-S-11 RYR2 PMC6685439__F1 Cholesterol biosynthetic/protein prenylation pathway RHO IPP CDC42 PMC137069__F1 Hh-signaling pathway SUFU RAB23 SMO GAS1 PMC6627634__F1 Diagram showing the different molecular mechanisms of canonical nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation NLRP3 MYD88 TNF FADD MLKL PMC7778498__F1 Endosteal, reticular, and vascular niches in the context of bone marrow BMP2 PTH DKK1 CXCL12 DKK2 WNT10B IL1B IFNG PMC4052696__F9 Pathway Bridge Based Multiobjective Optimization Approach for Lurking Pathway Prediction SMAD2 SMAD4 OCIAD2 PMC11660123__F3 AIM2 in regulating the development of breast cancer and LUAD independent of inflammasome BAD AIM2 STAT3 BAX PMC6627634__F2 Diagram showing the different molecular mechanisms of non-canonical NLRP3 inflammasome activations NLRP3 HMGB1 IL16 TLR4 SYK IRF3 MYD88 FADD PMC11660123__F2 AIM2 regulation in CRC, HCC, and RCC in inflammasome-independent manner MHC2TA MTOR AIM2 PMC4052696__F7 Based on experimental data GDS3634, miR-205 expression effect on prostate cancer cell line, from NCBI public database browser, P value of 8 samples of Student's t-test, microarray data was applied as the link cost for predicted paths CDON JUP GNAS TGFA PMC9003967__F11 Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGFB/SMAD3 signaling pathway MMP2 CCND1 CDH2 PCNA PMC6280921__F1 Cross-talk among different signaling pathways involved in MDSCs expansion, activation and function PTEN MYD88 PMC8356724__F1 The BMP-2 signaling pathway BMP2 SMAD4 SMAD1 TF DKFZp781O1323 PMC9374760__F1 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways TBK1 TANK IRAK1 IRAK2 RELB TRAF3 TRAF6 IRAK4 MYD88 STAT1 RIPK1 TLR4 CYLD ECSIT PELI3 CASP8 JUN MAL CD14 STAT2 IRF7 FOS IRF9 IRF3 PELI1 MAP3K7IP1 RELA TRAF1 SHARPIN LBP IRAK3 ELF4 OTULIN FADD STAT3 TAB3 PMC8430922__F3 Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases NGF ARHA PMC4172957__F6 Expression of genes in the canonical complement system pathway HEL-S-62p CS C4B_2 C6 C4A PMC4172957__F5 Expression of genes in the Th1 response network and interferon signaling pathway HRH1 HMGB1 PIK3R1 IFIT3 MOG IRF9 TYK2 MERTK PSMB8 SOCS1 IFNG PMC5130170__F1 Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway EGF EGFR GRB2 PMC9555085__F2 Current understanding of epigenetics role in melanoma treatment and resistance IGF1R SETDB1 ADRB2 IGFBP5 FOXO1 RET IGF1 DAB2IP DACT3 SRC GDNF EZH2 ME3 MLL2 CP PMC8566418__F2 Estetrol and Mammary Gland: Friends or Foes? PGR TFF1 SRC HSPB8 GREB1 TF PMC4960006__F7 Diagram represents the proposed model of APC regulation of miR-17-92 cluster APC GSK3B PTEN TCF4 PMC8898846__F4 Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses INA FOS POLK APC MYC APP GAST BAX PMC9128303__F1 IGF-I structure and activity TSC1 GRB2 PTEN RPS6 MTOR PMC2953417__F1 REGULATION OF NITRIC OXIDE PRODUCTION IN HEALTH AND DISEASE OTC ASL PMC7327052__F3 Centrosome aberrations trigger an immunosuppressive microenvironment TBK1 CGAS ANGPTL4 APC PMC7327052__F2 Centrosome aberration-associated molecular pathways in cellular senescence PCM1 CEP192 PMC4693897__F8 Proposed mechanism for zinc‐mediated inhibition of interleukin‐1B (IL‐1B) signalling and its role for repression of human T helper type 17 (Th17) responses TRAF6 IL1R1 IRAK4 MYD88 IL1B PMC7790916__F1 Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway PDE3B GSK3B PTPN11 PTEN TBC1D4 PMC6608000__F8 EtOH metabolism pathway regulates KLF4 expression and function MRC1 KLF4 ARG1 IL1B CYP2E1 PMC3662904__F1 Transforming growth factor (TGF)B signaling cascade SMAD2 SMAD4 SKI SMURF1 PMC5536940__F1 Transduction of platinum-induced DNA damage: DNA repair or apoptosis PALB2 ATM BRCA2 BRCA1 PMC8569351__F2 FOXO1: a pivotal pioneer factor in oral squamous cell carcinoma PRMT6 MDM2 ATG14 SGK1 SIRT1 FOXO1 RFWD2 PMC9579336__F3 Synthesis, function, and regulation of sterol and nonsterol isoprenoids PPM2C UBIAD1 HMGCR PMC9579336__F2 Synthesis, function, and regulation of sterol and nonsterol isoprenoids TH LDLR UBIAD1 IPP RHEB HMGCR PMC9579336__F1 Synthesis, function, and regulation of sterol and nonsterol isoprenoids SQLE RAP2B PPM2C ARHA RAP2C RHEB HMGCR PMC9133562__F3 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials PDGFRA PLG MTOR PMC9654076__F1 Molecular Targeting of the Most Functionally Complex Gene in Precision Oncology: p53 ATM MDM2 CDK4 ATR CDK6 BAX PMC5580270__F4 Changes in hepatic gene expression associated with the PPARA signalling pathway and fatty acid metabolism between broilers (n = 6) and layers (n = 6) ME1 ACACA NR1C1 HEL-S-32 GPAM FADS6 RXRA ACADL SCD LPL ACSL1 ACLY FABP1 FASN CD36 PMC8525106__F4 Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma FOXO4 BRAF HEL-S-1 ATF2 SKP1 GADD45A CASP2 RANBP2 CHEK1 BRCA1 RNF41 MTA3 EIF4G1 THRA PSMF1 TUBB4B ATM CDK2 YWHAG JUN CD3G PCNA TGFBI PMC9563254__F5 p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond EGR1 SOX2 SMAD2 MYC STAT3 PMC8475945__F3 Unfolded Protein Response Pathway in PC3 (A) and ARCaP(M) (B) cells CANX OS9 AMFR ERO1B EBP SP4 ATF4 HEL-S-99n BCL2 VCP TRAF2 XBP1 PMC3486458__F7 AMPK/ERK/TSC2/mTOR signaling in PCV2-induced autophagy in PK-15 cells TSC2 RAF1 MTOR PMC3842585__F2 Mutations in the ERK/MAPK signaling pathway and related second messenger systems JMJD1C GOLGB1 FGGY PLSCR5 GSK3B GADD45A IQUB PMC5717006__F2 Mevalonate metabolism in immune and cancer cells MYC ABCA1 MTOR IPP CD36 PMC9374760__F3 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways CEBPE PIN1 RNF11 TRIM55 SMAD2 MEX3C ATF1 MUL1 CCL5 CCL2 CCL1 NLRP7 NLRP9 IFNG TNFSF6 CYLD IFNA2 CCL19 PELI3 SP1 CSF2 AIM2 NAIP IFNL3 SCIMP IRF7 STAT2 FOS IRF3 CCL4 CEBPA TNF IL15 IFNK TRAF1 SHARPIN CCL20 ELF4 TGFB1 MLKL MAVS IFNA17 ITCH CGAS TANK IFNA1 IFNA4 CSF3 NLRP6 IFNL1 IFNL4 IL12A ZBP1 CEBPB IFNLR1 RIPK1 IL18 IFNA13 IFNA14 ATF4 IFNA10 CCL17 KITLG ECSIT JUN MAL CD14 TLR5 CCL11 IL13 IL36A IFNE LIF RIPK3 IL24 TLR1 TRIM25 TLR10 TLR3 LTA NFATC2 CCL15 TRIM32 RELA LBP TYK2 IL-21 CCL18 IL20 TRAF2 OTULIN FADD CCL3 STAT3 PMC9374760__F2 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways PIK3R1 S1PR2 CX3CL1 PTEN INPP5D SRC RGS1 ARHGAP5 PREX1 RGS6 ELMO1 ARHGEF1 ARHGAP24 GNA13 S1PR1 OPN1SW ARHA RGS2 RGS12 PIK3R5 CXCR4 PIK3CA GNAO1 CXCL12 DOCK2 CDC42 PMC9374760__F4 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways PIK3R1 PRKCZ MAPK8 EZR WAS PDPK1 DOK1 CFI PRKCA ITK FYN TMSB4X PC INPP5D PIKFYVE NCKAP1 PTK2B PID1 SRC BRK1 MAPK1 HEL114 ARHGAP5 PREX1 RGS6 PARD3 ELMO1 RAPGEF1 ARHGEF4 ARHGEF1 MAP3K1 ARHGEF7 WASF1 HEL-S-28 CSK WASF2 BAIAP2 APC ARHGAP24 GNA13 OPN1SW DOCK1 ABI2 RGS2 RGS12 FERMT3 CRK PIK3R5 ZYX CXCR4 GRB2 BCL2 GNAO1 CXCL12 NCF1 MYLK CDC42 S1PR2 BAD BRAF MAP2K4 CX3CL1 ARHGEF2 PTEN RGS1 JUN FOXO3A S1PR1 ARHA MAP2K1 ND1 NFKB1 RELA PIK3CA DOCK2 PXN PMC8576142__F3 Myeloid dysregulation and therapeutic intervention in COVID-19 CCL2 MYD88 CCL3 PMC8389562__F5 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer BPTF MYC USP28 ZNF121 CTNNBIP1 CBL BRD4 PMC8389562__F4 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer LIN28B FUBP3 MYC SPOP EZH2 IGF2BP2 PMC8389562__F3 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer LIN28B CUL4B CIP2A OGT MYC USP28 ZNF121 PRIMA1 LIN28A PMC8476494__F8 Hypothalamic-pituitary adrenal-axis, toll-like receptors, and macrophage polarization in pre-atherosclerotic changes induced by social isolation stress in mice TLR4 VCAM1 PMC7378251__F3 Expression of genes related to starch and sucrose metabolism, glycolysis, TCA cycle and amino acids pathway under CK, MD, AT and SD ASNS DLD ACLY PMC4381956__F1 Complement in Monoclonal Antibody Therapy of Cancer HEL-S-62p CD59 C9 C4B_2 VTN IMPACT C7 C6 C4A CR1 CFHR1 PMC1780025__F2 Heterogeneity of Pacemaking Ability among SCN Neurons Robust rhythm generation in SCN neurons CRY1 CRY2 PMC5527950__F2 Internalization routes influence signaling output WNT3A EGFR LRP6 PMC9133562__F2 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials BMPR2 ACVR2B ACVR2A RUNX2 ALK GRB2 TGFBR2 PMC3150418__F9 NFKB signaling participates in both Receptor Activator of NFKB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NFKB pathways RELA CD44 RELB DCSTAMP PMC5680911__F7 Simplified graphical scheme representing the effect of Caspase-8 depletion on hepatic apoptosis and steatosis in the pathogenesis of ALD CASP3 CASP9 TG CASP8 CYP2E1 PMC4081080__F3 miR-143/145 modulate signaling through the Ras-MAPK pathway RREB1 EGFR PMC5614474__F2 Multiple and bidirectional connections between actin dynamics and endocytosis TIAM1 HGF RAB25 ARF6 PMC7357716__F3 Metabolic Messengers: Adiponectin COX2 HEL-S-11 MAPK1 SIRT1 INSR PMC5460571__F4 Representation of the molecular interaction pathway analysis of the associated and causal genes linked to aneuploidy MTRR SMC2 APP DSCAM PMS2 PMC11507252__F7 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review MTOR DKFZp686F0183 PMC4533766__F7 Expression profile of P HEL-S-62p ACP4 ACP2 HEL-S-5 PMC7931557__F8 Proposed model of the mechanism underlying the expression and function of LINC00958 in TSCC cell proliferation AGO2 CCND1 CENPK CCNE1 PMC11507252__F6 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review NRF1 SIRT1 BAX PMC5614474__F3 Transcriptional programs controlling endocytosis and genetic reprogramming by endocytosis TFEB EGFR DRAM1 CHMP4C PMC11507252__F5 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review NLRP3 TLR4 MYD88 PMC8405670__F4 Comparative analysis of therapeutic effects between medium cut-off and high flux dialyzers using metabolomics and proteomics: exploratory, prospective study in hemodialysis SERPINC1 PROS1 IGF2 RBP4 KNG1 HABP2 CLU PMC3845601__F2 Wnt/Beta-catenin signaling pathway APC SOST LRP5 LRP6 WIF1 PMC6279509__F9 Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels MMP2 RUNX2 BMP2 MMP9 PMC9465090__F1 System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy GPX4 RRM2 SLC7A11 ATF4 EGFR HEL-S-64p LCN2 ATF3 SLC3A2 SP1 IPP PMC4654121__F6 Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells TSC2 TSC1 EIF4E MTOR RHEB RGS10 PMC10940142__F1 Schematic overview describing the target pathway and overall metabolic strategies for heme production SHD CP CPD PMC11727420__F2 Signaling interactions between the Wnt/Frizzled pathway, MINK1, Prickle1, and their downstream effects on cellular processes MINK1 PHLDB2 CLASP2 PMC5764090__F2 HiJAKing the Epigenome in Leukemia and Lymphoma EGR1 SOCS3 MYC NFKBIZ MYD88 BATF NFKBIA BCL2A1 NFKB2 JAK1 JUN IRF4 SGK1 STAT3 PMC5838326__F4 Changes in the hepatic expression levels of genes for gluconeogenesis pathway following castration of bulls PCK1 MCEE FBP1 ACSS3 DLD PFKL PCCA PCCB PC PDHA1 PKLR GPD2 PCK2 HEL-S-133P DLAT HK2 HEL-S-281 GPD1 PMC6316656__F2 Hedgehog pathway activation in cancer SUFU PTCH1 SMO IL6 PMC11727420__F5 MINK1 and Hippo pathway regulation MINK1 LATS1 LATS2 PMC5764090__F1 HiJAKing the Epigenome in Leukemia and Lymphoma EPO IL3 LIF TPO STAT3 PMC11727420__F4 MINK1 and JNK signaling pathway interaction MINK1 TNIK HEL-S-31 PMC11011055__F7 Targeting Siglec–Sialylated MUC1 Immune Axis in Cancer GNE NANS GAL PMC11854358__F8 Analysis of cell cycle pathways and differentially expressed genes because of different levels of PFESA-BP2 exposure SOCS2 EGR1 CCNA2 MAD2L1 TACC3 MYC BMF TOP2A PRC1 ECT2 MCM2 CDK2 CDK4 CDC2 PMC11854358__F7 Proposed effect of low-dose PFESA-BP2 exposure on the hepatic fibrosis signaling pathway in the liver [59] CCNA2 IGF1 BIRC5 EGFR MYC CDC2 PMC8730820__F2 Multiple MuSK signaling pathways and the aging neuromuscular junction MUSK LRP4 F2 SMAD4 CAD SMAD1 DKFZp781O1323 PMC6115007__F2 Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery BMP6 HFE TF PMC5576560__F2 Ten Strategies of Interferon Evasion by Viruses RNASEL STAT1 STAT2 IRF9 TYK2 IFNAR2 IFNAR1 PMC6868788__F8 Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway MMP2 CDK2 OTUD7B MMP9 CCND1 PMC8779696__F1 Host Non-Coding RNA Regulates Influenza A Virus Replication TBK1 ADAR PML STAT2 IRF7 IRF9 IRF3 JAK1 MAVS PMC11292300__F4 The rationale for possible targeted therapies in CMTC RET BRAF FOS APC MYC AXIN1 CCND1 PORCN PTEN MTOR STAT3 PMC11292300__F2 WNT signaling pathway in CMTC APC GSK3B MYC AXIN1 CCND1 PMC5337177__F2 Mechanisms by which mild mitochondrial uncoupling protects neurons against oxidative stress, excitotoxicity and the accumulation of disease-related self-aggregating proteins such as amyloid Beta-peptide, Tau and Alpha-synuclein TSC2 FOS ARC MCU MTOR BDNF TFAM SIRT3 PMC7933988__F7 Action of mesenchymal stem cells in the vestibular microenvironment IL16 MSC MYC NMI TNF STAT3 PMC7289712__F6 KEGG relationship network diagram HEL-S-44 IL6 CCL2 IL4 IL1B PMC7189706__F5 Hyperglycaemia may influence ten-eleven translocation (TET)-dependent O-GlcNAcylation of the histone methyltransferase SET1/COMPASS complex TET3 OGT TET2 PMC5714221__F9 H1 involvement in the repression of the interferon response STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 JAK1 IRF-1 PMC4471797__F1 Wnt/Beta-catenin signaling pathway APC GSK3B CCND1 BCL9 PMC6217807__F6 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma DAO EGFR MDM2 SHE CDK4 PTEN MTOR OLA1 CDK6 PMC5282855__F1 Biosynthetic pathways of tetrapyrrole compounds COBL CS PMC6217807__F5 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma BAD BAGE INS PTEN HIF1A PMC7688918__F3 In response to I/R injury, neutrophils migrate from the circulation to the injured heart in response to CXCL and release S100A8/A9 CXCL1 TLR4 NRF1 S100A8 IL8RB PMC8746635__F7 Anti-Inflammatory Activities of the Ethanol Extract of Prasiola japonica, an Edible Freshwater Green Algae, and Its Various Solvent Fractions in LPS-Induced Macrophages and Carrageenan-Induced Paw Edema via the AP-1 Pathway TLR4 MMP2 MMP9 MYD88 IL1B PMC8881374__F2 10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation RPL7A TBX3 MYC STKLD1 SNX11 OBP2B BMF WT1 GPR176 ADAMTSL2 RPL19 CDKN2A LPCAT1 SLC6A18 SKIDA1 CDK6 KNSTRN MED17 HOXB4 HOXB2 SURF2 CACFD1 FAM163B WNT4 SSPN ANKRD63 DBH ADAMTS13 RSL24D1 BHLHE41 BAHD1 EEFSEC RPL35 RPS16 RPL18A MED22 RXRA PLCB2 CBX1 HEY2 WASL RAB11FIP4 SLC2A6 HOXB6 CDC42 TERT NKD2 GNL2 CCND1 CDK4 PARD6A RPS12 SH2B3 HOXB7 SRP14 SLC6A19 ABO AURKA RPL8 EP300 EIF2AK4 HEL-S-81p PMC2877394__F1 ER and SR interactions within mammalian cells ULK1 HP BCL2 UVRAG MTOR XBP1 STIM1 PMC3239234__F3 Various signaling pathways modulated by the primary cilium LRP5 SHH LRP6 SMO PMC4161976__F7 MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer SIRT6 MDM2 PMC9259972__F2 Long Non-coding RNA HOTAIR in Central Nervous System Disorders: New Insights in Pathogenesis, Diagnosis, and Therapeutic Potential NLRP3 LRRK2 RAB3IP CDK5R1 MYD88 EZH2 ATG10 BDNF IL1B BAX PMC5779720__F2 Distribution of fluxes in the central metabolism predicted by pFBA for the models: iFF708 (green), iMM904 (blue), iTO977 (orange) and Yeast 6 (black) PDC CIT MAL PMC2720726__F1 IFNB activated pathway STAT1 STAT2 IRF9 IFNAR2 IFNAR1 IRF-1 PMC9376318__F3 CXCL5: A coachman to drive cancer progression CXCR3 CXCL5 GSK3B IL8RB SOX9 STAT3 PMC5779720__F4 Flux distributions simulated with lMOMA for the mevalonate mutant (A) and the acetate mutant (B) using the improved flux distribution as the reference PDC PC SUCO CIT MAL PMC6803553__F3 Signal transduction of GDF11 BAMBI ALK TRAF6 GDF11 PMC6202106__F7 The TGFB/BAMBI pathway BAMBI RORC SMAD2 FOXP3 PMC2238720__F2 Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions IRAK1 RELA RELB TRAF6 IRAK4 MYD88 PMC5190068__F3 KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer S100A14 KLF4 KCNN4 PMC7550684__F1 Signaling pathway of Interleukin-17A (IL-17A) TRAF5 TRAF6 TRAF2 ARID5A PMC10178416__F2 Schematic drawing presenting signaling pathways affected by ferulic acid TLR4 KEAP1 SMAD2 SMAD4 TGFB1 BAX PMC9495760__F1 Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? IL6 IRS1 IL1B INSR PMC4331476__F4 Representative illustration of key gene distribution (hsa04720 and LAP_hsa04720s) PPL PMC3232027__F2 Identification and development of mPGES-1 inhibitors: where we are at? COX1 PMC4030640__F2 Molecular and biophysical characterization of the human blood-nerve barrier: Current concepts RET GDNF PMC3994981__F2 PI3K and Cancer: Lessons, Challenges and Opportunities RICTOR ULK1 MYC PTEN EIF4E GRB10 MTOR RHEB PMC3994981__F1 PI3K and Cancer: Lessons, Challenges and Opportunities PIK3CA PTEN MTOR PMC6101676__F1 Mevalonate-isoprenoid-cholesterol pathway and pharmacological agents that inhibit the synthesis of key intermediates RHO IPP HMGCR PMC10272955__F8 Graphical summary of the signaling pathway that mediates fenofibrate (FF)-induced cytoprotection against cisplatin toxicity AHR KEAP1 PMC4839493__F1 The metabolic pathway for vitamin D FGF23 CYP2R1 CYP24A1 PTH CYP27B1 PMC4839493__F7 1,25(OH)2D3-induced signaling pathways involved in the regulation of cell proliferation, apoptosis, and inflammation in cancer NR1i1 CDK2 HEL-S-11 APC EGFR CCND1 IL6 BAX PMC8106830__F1 Cascade of innate immune response against intestinal fungi CXCR1 CARD9 SYK PMC2653622__F2 PRIMARY CILIUM: AT THE CROSSROADS OF MAMMALIAN HEDGEHOG SIGNALING SUFU GLI3 SHH SMO PMC8146326__F8 Extracellular Vesicle Release Promotes Viral Replication during Persistent HCV Infection ROCK2 ROCK1 ARHA ARF6 PMC4452063__F2 The Wnt/Beta-catenin signaling pathway and the regeneration therapy drug candidates discussed in the paper APC SOST LRP5 LRP6 BCL9 PMC4452063__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper APC LRP5 LRP6 BCL9 PMC7645992__F10 Prosed schematic proposed mechanism underlying the impact of DDP4 inhibition on protecting the cell from apoptosis and oxidative stress through regulating the PI3K/AKT/m-TOR signaling pathway IL6 MTOR IL1B PMC4434706__F1 Two S-phase checkpoint responses in S MRC1 RAD17 DNA2 PMC7550684__F3 Relationship between IL-17A and astrocytes SOCS3 IL1B STAT3 PMC11993841__F6 Influence of porous metal materials on osteogenesis RUNX2 PMC11899827__F1 IL-17 signaling pathway in the pathophysiology of spondyloarthritis ERAP1 TNF IL23R IL17RC PMC9187083__F9 Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice STAT1 EGR2 IL13 SMAD2 CXCL10 MYD88 TIRAP STAT3 FOXP3 PMC2692823__F2 Hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem KY TRPC6 STIM1 PMC9585190__F7 Metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies SUFU SHH SMO PMC8062309__F2 T helper cell changes locally and peripherally in healthy pregnancy and preeclampsia CD80 IFNG PMC8062309__F1 Local and systemic complement activation in preeclampsia and healthy pregnancy and complement-modulating medications HEL-S-62p CD59 CD46 CFH CD55 C1S CFHR1 CFI PMC4487780__F1 NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus NAPRT NAMPT HEL-S-90n NMNAT1 NMNAT2 NMNAT3 PMC3316974__F1 AKT-mTOR signaling pathway showing rapamycin inhibition sites in astrocytomas TSC2 TSC1 PTEN MTOR PMC3159974__F4 Predicted synthetic lethal gene pairs in TCA cycle (A), phosphatidylserine biosynthesis (B) and pentose-phosphate pathway (C) PTDSS1 PC CEPT1 HEL-S-304 RPIA CHPT1 PCYT2 PTDSS2 RPE PMC209477__F2 gp130 cytokine family pathways on anterior pituitary cells CNTF CD14 LIF LBP OSM PMC8328385__F1 Alopecia Areata: An Autoimmune Disease of Multiple Players CXCR3 PDC CXCL10 CXCL9 CXCL11 ELL PMC5592089__F1 PI3K/AKT/mTOR pathway and interaction with PTEN and TSC1/TSC2 BAD TSC1 EGFR GRB2 PTEN MTOR IRS1 TTF1 RHEB PMC5520933__F1 The lithium targeted cellular and molecular mechanism by activating several neurotrophic and associated signaling in Alzheimer’s disease APP GSK3A REST BDNF PMC6513185__F4 Effects of flavonoids on signaling pathway of NLRP3 inflammasome activation NLRP3 TLR4 SYK TXNIP IL1B PMC6412533__F10 Gemcitabine pathway extracted from PharmGkb database CDA RRM1 RRM2 DCTD SLC29A1 SLC28A3 CMPK1 PMC4468843__F1 NFKB pathway COX2 MYD88 IL1B PMC7235190__F5 Regulatory mechanism of HDAC2/3 on LPL expression in SH-SY5Y cells HDAC3 LPL HDAC2 PMC4061164__F1 Cisplatin-induced inflammation is mediated through multiple effectors including activation of NFkB, TNFA, and PARP HGF VCAM1 STAT3 PMC6513185__F2 Flavonoids on the expression of MMP and ADAMTS in osteoarthritis STAT1 STAT2 PMC6099536__F1 IL-33 signaling pathway IRAK1 SIGIRR IL33 UNK IRAK4 MYD88 PMC3094853__F1 CHS-catalyzed synthesis of unnatural polyphenols from cinnamoyl-SNAc starter substrates with a) malonyl-CoA and b) methylmalonyl-CoA as extender units CSA2 RRH PMC9253771__F3 Combinatorial CRISPR Interference Library for Enhancing 2,3-BDO Production and Elucidating Key Genes in Cyanobacteria TRO PMC3780472__F2 Biochemical changes during EMT in fibrosis ZEB2 CDH2 PMC5929146__F1 Metabolomics Applied to Islet Nutrient Sensing Mechanisms HEL-S-26 PC CIC PMC3270883__F1 Exiting from uncharted territory: hepatitis C virus assembles in mouse cell lines SCARB1 CLDN1 LDLR APOE CD81 PMC6539061__F2 Polycystin-associated pathogenic mechanisms in human diseases STAT1 RUNX2 STAT3 PMC7177523__F2 Schematic figures showing various signaling molecules influenced by the CO-HO-1 pathway TSC2 TSC1 GSK3B TBC1D7 PTEN AMIGO2 MTOR SIRT1 RHEB PMC7345337__F5 Gene–gene interaction network analysis MAPK9 BRAF ATG12 MOS NRAS HRAS USP11 PIK3R3 INSR TSC2 CREBBP IGF1 MDM2 GRB10 SGK1 PMC6406504__F2 Differentiated insulin-producing cells (IPCs) for transplantation PDX1 HGF HP SHH TF PAX4 MAFA PMC11534612__F1 Pathophysiologic roles of IL-17 signaling in cardiac fibrosis CXCL1 CDX2 TRAF5 CXCL5 CXCL10 CXCL8 TRAF6 IL6 IL17RB TRAF2 IL17RC PMC7957753__F9 Signal transduction and regulation of secondary metabolism in response to salt stress in S MYB MYC TF PMC4032892__F1 Schema of PI3K/mTOR and other oncogenic signaling pathways in hematologic malignancies PTEN EIF4E MTOR PMC4516161__F4 CIB1 regulation of TNBC cell survival and potential role of CIB1 in non-oncogene addiction PAK1 PTEN PMC4316650__F3 Pathways and networks associated with proteins with differential abundance according to IPA FGA KLK8 CS APC TYMP AMBP HEL111 HSPG2 HP LMAN2 F2 CRP LBP MASP2 SERPINA1 APOH CP TF PMC4956769__F4 Features of an altered AMPK metabolic pathway in Gilbert’s Syndrome, and its role in metabolic health PGC SIRT1 UGT1A1 PMC4283800__F1 Hypoxia and the extracellular matrix: drivers of tumour metastasis LOXL2 P4HA2 LOXL3 LOXL4 PLOD1 P4HA1 PLOD3 P4HA3 LOXL1 PLOD2 PMC4766460__F2 Plasticity of gene‐regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators RSPO1 SOX3 NR3A2 SF1 AMHR2 DMRT1 DKK1 SOX8 SOX9 PTGDR FGF9 SRY PMC6554024__F5 Decoding type I and III interferon signalling during viral infection STAT1 STAT2 IRF9 TYK2 JAK1 PMC6554024__F4 Decoding type I and III interferon signalling during viral infection TBK1 CGAS TLR7 IRF7 RIGI IRF3 MYD88 TLR3 MAVS PMC5417569__F6 Transcriptome analysis of muskrat scented glands degeneration mechanism NODAL PITX2 SMAD2 SMAD6 SMAD4 SKP1 ARHA TNF RBX1 LTBP1 IFNG FST SP1 SMAD1 PMC4404594__F1 Model of CIP2A involvement in the EGFR-RAS signaling pathways CIP2A EGFR PMC5417569__F5 Transcriptome analysis of muskrat scented glands degeneration mechanism PLN TNC BCR CAV3 MCU CAV2 PMC10539698__F3 Emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages CCR5 COX2 CCR2 MTOR STAT3 PMC5938036__F2 The metabolites generated from alternative vitamin D metabolic pathway CYP27A1 NR1i1 CYP24A1 CYP11A1 RORA CYP27B1 PMC5287080__F3 Transforming growth factor B (TGFB)-induced activation of the PI3K-Akt pathway TWIST1 SMAD4 PMC5287080__F2 Transforming growth factor B (TGFB)-induced activation of c-Jun amino terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling, and the IKB kinase (IKK) pathway SMAD2 SMURF2 SMAD6 SMAD4 TRAF6 PMC5287080__F1 Transforming growth factor B (TGFB)-induced activation of the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinase (MAPK) pathway SMAD2 GRB2 SMAD4 PMC3397508__F1 Possible molecular mechanisms of Ngb neuroprotection by modulating cell death/survival signaling pathways HEL-S-62p CYC1 NGB PMC4306509__F6 Human disease mutations in short linear motifs BAD CDK2 MDM2 BCL2 PTEN MTOR NKX3-1 PMC7809767__F3 AURKA interactome and related signaling pathways LIMK2 TACC3 GSK3B RALA SMAD4 AJUBA BCL2L11 GABPB1 AURKA LATS2 ZNF207 PRKCA IKBKB NFKBIA NF2 CPAP MDM2 KCTD2 GABPA CENPA PMC8905338__F5 Personalized Management of Pheochromocytoma and Paraganglioma NF1 RET FGFR1 MAX EGFR MERTK SSTR2 HDAC1 TMEM127 PMC2907875__F8 Estrogen and Xenoestrogens in Breast Cancer RARB BMP6 SPRY1 NRG1 STXBP6 PMC5742588__F3 The folate cycle is fueled by the serine synthesis pathway (SSP) and extracellular serine PSAT1 SHMT1 PSPH MTHFD1 HEL-S-51e PMC3387977__F3 Targets for inhibition within the EGFR signaling pathway EGF EGFR MTOR TGFA PMC8669111__AF1 Glutathione synthesis primes monocytes metabolic and epigenetic pathway for Beta-glucan-trained immunity GCLC EZH2 MTOR CIT HK2 GLS PMC3804751__F7 Model showing the cRAF-dependent modulation of DC responses by TcES IL10 TLR4 MYD88 PMC6933576__F11 Apoptotic pathway and targets for complexes 1, 2, 3, and 4 CASP3 CASP9 CASP8 PMC4401614__F1 Cbl pathways APC CBL PMC4046670__F6 Prioritized genes in apoptosis and TNFR2 signaling pathways BAD PMC4086377__F1 TGFB Signaling in Wound Epithelialization SMAD2 TGFBR1 SMAD6 SMAD4 TGFB1 PMC9162042__F3 Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review) RIF1 ATM USP14 MDC1 FOXK1 SP1 ATR H2AX CUL4A BRCA1 DTL PMC6171999__F1 Targeting B-cell receptor signaling in leukemia and lymphoma: how and why? BTK BCR BASH LYN GRB2 RAC1 PMC5356579__F2 Somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy IGF1R BRAF SMAD2 TGFBR1 MYC TGFBR2 SMAD4 PTEN DKK1 DKK2 FBXW7 SOX9 ACVR2A ATM AXIN2 FZD10 DKK3 ERBB3 IGF2 APC LRP5 TCF7L2 ARID1A DKK4 ERBB2 PMC5122439__F2 RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action IGF1R BRAF EGFR GRB2 SPRED1 SOS1 HRAS ARAF PMC3693464__F1 Transcriptional Control of Cellular Metabolism by mTOR Signaling NF1 TSC2 TSC1 ATM EGFR PTEN RHEB PMC3806867__F5 High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells SPARC CD47 LAMP2 ETV4 RAB31 PTEN SLPI ITGB1 ID1 IGFBP5 TAGLN S100P PLAT TIMP3 KLK3 NOTCH1 HEL113 TMEPAI PCK2 pp6425 WNT5B EMP1 PMC8818677__F9 Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IKBA ULK1 MTOR SKP2 PMC9708732__F3 Microglia autophagy in ischemic stroke: A double-edged sword NLRP3 ULK1 TLR4 ATG12 BNIP3 TRAF2 DKFZp686F0183 PMC12078810__F7 ART inhibits hepatocellular carcinoma cells TLR4 TRAF6 MYD88 PMC5954603__F1 Involvement of exosomes in peritoneal dissemination EGFR CD44 LAMC1 PMC3061884__F9 100 frequent associations obtained after p value cut off in MCL with CDCOCA CARD11 NSMAF RPL30 HEL-S-93 SMARCE1 TRAF4 PMC8977221__F1 Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook HEL-S-92n CD80 PMC9484955__F6 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy FUNDC1 MEN1 BNIP3 FIS1 OPA1 PMC7247011__F5 Fe deficiency responses in photosynthetic organisms FER PC FES PMC8745381__F3 Melatonin in Obesity: A Review NLRP3 TLR4 EPO ANGPTL4 MPO NFIL3 SIRT1 STAT3 PMC7247011__F3 Fe-responsive proteins with relevance for photosynthesis in Cyanobacteria, Chlamydomonas, and land plants FER FUT8 PC FES NACA PMC9484955__F1 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy NLRP3 IL18 RYR2 BAX PMC8955027__F2 Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells CS HADHB CRAT PFKM PYGB EN2 MDH2 HEL-S-26 GOT2 ACADS FH MSC PDHA1 PKLR ACO2 GPD2 OGDH SUCLG2 PDHX PFKP DLAT PGAM1 SDHB SLC25A20 HEL-S-30 ENO1 DLD PHGDH HEL60 HEL-S-162eP HEL-S-68p HEL-S-49 ACADL CPT1A ACADVL ENO2 SUCLG1 SUCLA2 ACLY ECHS1 SLC25A1 PYGL ACADM AGL PMC7910587__F6 Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry EGFR IQGAP1 SRC RAC1 CDC42 VAV2 PMC3061884__F7 100 frequent associations obtained after p value cut off in BLCA with CDCOCA PPP3CC PSMD2 FNTA PMC6005571__F10 Neurogenesis and mediators of neuroendocrine stress responses NAMPT EGR1 SH3GLB1 NTRK1 CTCF CDK5 EDIL3 GABRB2 PENK SERPINE2 TRPV1 CCNI CAMK4 PAWR CARTPT NEUROD1 VSTM2A DAB1 CDK5R2 RAD21 PMC5979342__F5 miR-302s target genes are involved in the loss of epithelial phenotype KAT2B FZD3 ADAM9 APC PCDH7 TGFBR2 CD44 DRD1 LAMA3 FGF9 ITGB4 LEF1 LMX1A CDH6 RNF6 BTG1 PKD1 TNS1 GDF11 PRRX1 ZBTB33 BARX2 INHBB PMC6072839__F2 Molecular signalling of TRAIL RIPK1 TRAF2 FADD PMC5396384__F3 Inositol polyphosphates synthetic pathway IP6K1 ITPKC ITPK1 IPMK ITPKA PPIP5K1 PMC8410881__F1 Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression RS1 HEL-S-30 PFKM HEL-S-87p PFKP HK2 INSR PMC8121456__F2 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC8121456__F1 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease TBK1 CGAS TLR9 IRF7 IRF3 MYD88 AIM2 IL1B PMC11956211__F6 Apoptosis signaling pathway in KEGG PIG59 USP21 CASP2 TNF NLRP3 ATM HEL-S-11 CYLD IL33 ADA CAD H2AX OSM FADD MLKL PYGL TF PMC8745310__F1 Ubiquitin Signaling in Innate Immune Response by Herpesviruses TBK1 USP15 OTUD1 RNF122 TRIM21 IRF3 TRIM29 TRIM25 TRIM65 RNF125 TRIM40 MAVS ITCH PMC8131930__F3 Aspergillus fumigatus and aspergillosis: From basics to clinics F2 PMC8660704__F7 DCZ0014, a novel compound in the therapy of diffuse large B-cell lymphoma via the B cell receptor signaling pathway BCR LYN CCND1 SYK CDK4 MTOR CDK6 CD19 STAT3 PMC10925712__F1 Schematic biosynthetic pathways of tocopherol and tocotrienol synthesis IPP PMC8745310__F3 Ubiquitin Signaling in Innate Immune Response by Herpesviruses NLRP1 USP47 BRCC3 ARIH2 AIM2 IFI16 PMC8745310__F2 Ubiquitin Signaling in Innate Immune Response by Herpesviruses TRIM41 TBK1 CGAS RNF185 USP20 MUL1 IRF3 TRIM29 RNF5 TRIM32 CYLD TRIM56 USP44 USP29 PMC11674646__F1 Interactions and connections between the gut microbiota, metabolites, and cellular components with IBS COX2 AHR BMP2 PMC8787237__F3 STING1 in sepsis: Mechanisms, functions, and implications CASP3 MITA IRF3 PMC11795048__F1 Design and application of A@HAP NPs in cancer therapy HMGB1 NPS STAT3 PMC2376838__F8 LRG-Accelerated Differentiation Defines Unique G-CSFR Signaling Pathways Downstream of PU.1 and C/EBPE That Modulate Neutrophil Activation EPO TF STAT3 PMC7181720__F1 Proteomic analysis of the OTULIN protein complex TSC2 ATP2C1 TRIM32 PUM1 GNL3L OTULIN OSBPL8 HK2 PMC5045091__F2 Modification of the HIF-mediated switch to anaerobic respiration in osteoclasts.Notes: Osteoclasts specifically increase flux through both the glycolytic pathway and mitochondrial ETC to provide ATP and ROS necessary for bone resorption NFATC1 PFKFB4 PMC8955970__F1 Endometrial Cancer Stem Cells: Where Do We Stand and Where Should We Go? EGF SOX2 MTOR PMC3546980__F7 Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo KIF7 TIMP1 SUFU MYC SHH SMO MTOR PMC10559930__F1 Mechanism involved in ZNF703 including the signaling pathway, upstream regulation network and downstream targets RB1 CLDN4 MTOR DCAF7 NCOR2 ZNF703 PMC10897204__F6 Newly identified APA-linked cancer susceptibility genes are enriched in metabolic reprogramming and apoptosis-related pathways PIK3R1 SMG9 FBLN2 BBS2 ZNF276 POLR2J RUTBC3 FGF10 NOTCH1 SRC PREX1 CYBC1 HMGN3 VPS35 STRADB NBPF19 TMEM138 CHMP4A SUPT4H1 BAK1 SLC17A9 SLC25A37 FAM177A1 TLK1 KANSL1L ARL14EP UTP4 YIPF4 CALHM6 CASP10 SPATA33 RUNDC1 BRCA1 STRADA CBX8 BRCA2 CMC2 RASA4 POLR3C NCF1 HEL107 TERT ARMC10 DMXL2 PTEN CHEK2 BPTF ZNF346 MAU2 GGCX SRP14 STXBP4 PHF5A RNF181 ATG10 SPG7 MAP2K1 PIK3CA RAF1 HEL-S-20 PLEKHO1 PMC8656491__F1 Impact of DNA Damage Response—Targeted Therapies on the Immune Response to Tumours WEE1 ATM SSB PARP2 PARP1 PMC5803917__F4 AP1 and CEBP mediated skin barrier impairment by BM PLCG1 FYN CASR PKN2 CD44 PIK3CA SP1 JUN TF CEBPB PMC5803917__F3 TNF mediated anti-inflammatory effect of BM GC CCL2 SELE PMC5803917__F6 Factors implicated in manifestation of disease during drug treatment SOCS3 PC PRKCB RB1 CRK PXN PMC7882032__F4 Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity TSC2 TSC1 ATM MDM2 SESN1 SESN2 ATR PMC8626541__F1 FA-BRCA Pathway REV1 PALB2 FANCD2 BRCA2 SLX4 FAAP24 RAD51 FANCM UBE2T PMC6493882__F2 Two potential grounds for attenuation of IFN‐B bioactivity by statins IL10 STAT1 IL4 TNF IFNG PMC7498011__F5 Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases PIK3CD HLA-E PLSCR1 IKBKE CYBA PRKCE KLRF1 C1QBP TRIM21 TRAF3 IL31 DRD2 UBB CAPZA1 CORO1A TNFRSF9 ITK IL18 HEL-S-78p TNFRSF4 IFNA13 RPS27A FCER2 PRG2 SRC IL24 ITGB1 DEFB123 SRMS IL10RB HLA-F POLR3K IL27 IL6ST JAK1 LTBR PDCD1 PMC5206550__F1 Hypothetical representation of the link between the Hog1 MAPK and the lipid metabolic pathways activated in R CDS1 PSD2 PMC2808241__F7 Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice DNER ANKRD2 MYC TEAD4 IVL TTN NOTCH3 FBXW7 GAA PRELP MYH4 TCAP FLG NOTCH1 NRAP MFAP2 JUN PGAM2 SFRP4 FOS ENO1 NID2 PSMD3 BIRC2 MARCKSL1 LMO1 PMC12133740__F1 Integrated schematic of glycolysis, mitochondrial metabolism, and lipid pathways in NSCLC cells CPT1A MPC1 HEL-S-133P HK2 FASN PMC3703418__F2 Cellular mechanisms of BBR in reverting dysfunction in NAFLD IL6 NR1C1 INSR PMC12133740__F3 Targetable metabolic pathways and inhibitors in NSCLC ALK EGFR MYC OTC MTOR PHGDH HEL-S-68p SLC7A5 SMVT SCD PSAT1 PSPH SLC3A2 ACLY ARG1 ASS1 HEL-S-133P ASL FASN PMC4935775__F1 Na+-Cl− cotransporter (NCC) regulation by the cullin-3 (CUL3)/kelch-like 3 (KLHL3)-with no lysine (WNK)-STE20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress response kinase (OSR1) pathway KLHL3 OSR1 PMC10498649__F2 Lipid metabolic alterations induced by oncogenic events and TME cues MYC ACSS2 PTEN ACLY GLUD1 FASN CD36 PMC3671288__F2 Inhibitory pathway of PGE2 in effector T cells CSK LCK FOXP3 PMC3671288__F1 General overview of synthesis pathways for eicosanoids COX2 PC COX1 PMC8703113__F3 Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease MTOR PMC9017014__F1 Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy WNT3A RUNX2 LRP5 TCF7L2 PMC3871639__F5 Inflammation Regulates TMPRSS6 Expression via STAT5 BMP6 TMPRSS6 SMAD1 DKFZp781O1323 STAT3 PMC9266358__F8 Transcriptomic and Metabolomic Analysis of Quality Changes during Sweet Cherry Fruit Development and Mining of Related Genes PDC MAX SORD KHK ACLY APOH CAD PMC3188880__F2 Stat3 interactions in glioma biology EBP LIF OSM BMP4 IFNG STAT3 PMC6257835__F7 Involvement of circRNAs in the Hippo signaling pathway FZD3 HEL-S-1 BIRC5 SMAD2 PPP2R2C GSK3B SNAI2 CTNNA3 SMAD4 DLG4 FRMD1 BMPR2 BMP5 RASSF6 PARD3 BMP8B PRKCI TP53BP2 AREG YAP1 DLG2 TCF7L2 CTNNA1 FZD4 FBXW11 WNT10B FZD5 YWHAQ PPP1CC HEL-S-80p TP73 PPP2CA TGFB1 CTNNA2 CRB1 BTRC HEL2 PARD6G TGFBR1 PARD6B TGFBR2 PPP2R1A LATS1 MOB1A FZD1 MOBKL1A LATS2 CCND2 BMP4 TEAD3 NF2 FZD7 AXIN2 YWHAG PPP2R2A GDF6 WWC1 SOX2 WNT16 BMP2 BMP7 SCRIB PPP2R1B WWTR1 ID1 DVL3 PS1TP5BP1 PPP2R2B LEF1 GIG8 BMPR1A BBC3 HEL-S-93 FRMD6 PMC6257835__F6 Involvement of circRNAs in the ErbB signaling pathway EREG PIK3R1 MAPK8 GSK3B PLCG2 STAT5B CRKL NCK1 PRKCA BTC SRC MAPK1 ABL2 SOS2 AREG CDKN1B ERBB3 MAPK10 NRG2 HBEGF CRK PIK3R3 PIK3R5 PAK1 PRKCB CDKN1A RPS6KB2 GRB2 SHC4 TGFA AKT3 NRG3 EGF BRAF NCK2 MAP2K4 EGFR PAK6 PAK4 MTOR SHC3 ERBB4 JUN CAMK2D CAMK2G NRG1 CBL RPS6KB1 MAP2K1 ERBB2 PIK3CA RAF1 SOS1 NRG4 SHC1 CAMK2A PIK3R2 PMC8438979__F4 UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve LTA DIO1 LTB PMC5737940__F2 Cellular signaling pathways through which NELL-1 works NELL1 RUNX2 APC GLI3 GSK3B LRP5 LRP6 SMO PMC10887358__F2 Signaling pathways of B cell receptor (BCR) FYN BCR BASH CD22 LYN SYK PLCG2 CD79B CD79A PMC12154347__F7 Dihydrocapsaicin Enhances Tumor Necrosis Factor-Alpha-Induced Apoptosis and G1 Cell Cycle Arrest in Human Cervical Cancer Cells Through TAK1-Mediated NFKB and EGFR Pathways EGFR CCND1 TNF PMC8610843__F3 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications NLRP3 HMGB1 TLR4 VEGFA SRC CXCL12 TNF ACE2 PMC7320752__F6 Protein interaction pathway analysis in metastasis PIK3R1 PKIG AGTR1 FLT4 MYC GSK3B RB1 TFDP1 E2F3 CDK6 POLE2 FGFR1 POLE KSR1 WNT8B NOTCH1 DVL2 DTYMK DUT CSNK1A1 SP1 SOS2 BAK1 ORC6 APC LRP5 FGF16 LRP6 TCF7L2 UBE2B DDB2 WNT10B FZD5 UBE2A SHC2 WNT3 IGF1 TNFSF11 NFKB2 CDKN1A VCAM1 RPS6KB2 AXIN1 ZFYVE21 AKT3 SUMO1 FGF21 SUMO3 FGF4 SUMO2 UBE2M PGR JAG2 VPS4B DLL3 DBF4 NOTCH3 ORC3 ORC2 FGF20 FGF9 HEL-S-70p FGF22 TCF7L1 ARAF FGF7 CCNE2 NOTCH4 KIT WNT16 REXO2 WNT9B FGF18 SBDS PHGDH LIMS1 IGBP1 UBE2C LEF1 ERBB2 UPF2 WNT10A WNT5B SHC1 FZD8 PIK3CD WNT1 FGF8 ATP6V1C1 PRIM2 PRIM1 ATP6V1E1 HES1 HES5 WNT4 POLA2 FGF3 ADSL FGF10 FGF19 ILF3 MCM10 UFC1 PGAM1 FZD10 WNT7B NOTCH2 TNIK FOS MCM7 HRAS FGF17 BRCA1 MCM3 ZFYVE19 MCM5 ARHGEF35 MCM6 SH3GL2 HEY2 PROSER2 MCM2 POC5 CDK2 BRCA2 WDR51B WDR45B GRB2 HEL-S-52 WNT8A SHC4 APC2 ZRANB2 EGF IGF1R BRAF NR3A2 EGFR WNT7A EIF5A SAE1 WNT9A PTEN ITGA4 MTOR SHC3 FZR1 FGF23 E2F2 DLL4 CCND1 FZD7 UNK CDK4 NCOA1 FRAT2 JUN BAX RPGRIP1L UBXN7 FGF2 FGF6 DCTD DVL3 DVL1 RPS6KB1 MAP2K1 WNT3A AHCYL1 RTN1 PIK3CA RAF1 FRAT1 INSL4 SOS1 PIK3R2 PMC5518631__F1 Agrin signaling and YAP in neuromuscular junction formation (NMJ) and liver cancer development MUSK LRP4 PMC7191280__F1 SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications ATR ACE2 ADAM17 TMPRSS2 IFNG PMC7086350__F1 DDR core gene amplification across pan-cancer REV1 NHEJ1 PALB2 FANCD2 TDG NBN ALKBH3 POLL UBE2T UNG RBBP8 TP53BP1 PMS1 XRCC5 MLH3 POLE APEX1 ATRIP POLE3 MSH6 RAD50 ERCC5 REV3L RAD52 RAD51 MSH3 MSH2 TDP1 BRIP1 MDC1 XPC BARD1 BRCA1 BRCA2 ALKBH2 SLX1B ERCC1 ERCC2 ATR BLM RNMT FEN1 CHEK2 APEX2 ATM PRKDC XRCC3 GEN1 EME1 PARP1 POLN CHEK1 PMS2 TREX1 FANCM FANCL FANCA FANCB POLM PMC8130467__F5 Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis VWF MYD88 ACE2 TMPRSS2 PMC3594545__F2 Regulation of NFKB by Ubiquitination TBK1 TANK IRF3 TRIM25 MAVS PMC3594545__F1 Regulation of NFKB by Ubiquitination SHARPIN TRAF6 IL1B TAB3 PMC6779827__F2 Innate immune pathways inhibition by calicivirus infection F9 IRF3 EIF4E PMC8105803__F7 Map of p53 signaling pathway regulated by LEP gene drawn through the KEGG database TSC2 BAD TLR4 BCR SYK PTEN PMC8105803__F6 Map of PI3K/AKT/mTOR signaling pathway regulated by the LEP gene drawn through the KEGG database TSC2 AIFM2 PERP ATM HEL-S-11 MYC MDM2 CASP9 PTEN ATR PMC6311566__F1 Overview of metabolic pathways implicated in epigenetic modifications in NSC SIRT1 TET2 PMC8902310__F3 Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC TBK1 CGAS ENPP1 STAU1 TRAF3 IRF3 TLR3 MAVS PMC4914279__F8 Epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells ROCK2 ROCK1 EGFR ARHA RAC1 CDC42 PMC3361682__F2 UCB interaction with neural plasma membrane (A) and pathways by which UCB may affect neuronal function (B) C9 TRAF2 BAX PMC4935960__F6 Independent Tumor Origin in Two Cases of Synchronous Bilateral Clear Cell Renal Cell Carcinoma EGFR VHL RING1 PTEN WWP1 MTOR SUFU PTCH1 FGF10 KDM5C SMO UBE2Q2 SMAD1 PMC6678135__F7 Compounds that inhibit and activate autophagy ULK1 ATG12 ATG3 ULK2 UVRAG ATG10 MTOR ATG14 DKFZp686F0183 PMC8446193__F2 Murine Models Provide New Insights Into Pathogenesis of Chronic Graft-Versus-Host Disease in Humans TH PDC APC TEC CD69 STAT3 PMC6538418__F1 Key players in autophagosome formation ULK1 ATG12 ATG3 BCL2 ULK2 MTOR ATG14 DKFZp686F0183 PMC11356322__F3 Metabolic pathway interaction network of Cluster-0 metabolite (4-hydroxybenzoic acid) SULT1A1 SQLE KMO COQ2 COQ9 COQ6 COQ5 PDSS1 PMC7002700__F5 Schematic showing the signaling pathway of miR-125a-3p- Fyn–NRP1 interaction by TNFA in DPSCs FYN NRP1 DSPP PMC5642637__F2 miR-708-5p: a microRNA with emerging roles in cancer KPNA4 CD44 NNAT PMC6788064__F2 Signaling pathways participating in the function of cadherins in cancer APC PTEN CDH2 PMC8610843__F1 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications NRP1 ACE2 TMPRSS2 PMC9652569__F5 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking CCNA2 MAPK8 MYC MAPK14 CXCL8 BCL2L1 CCL2 RB1 SLPI HMOX1 IFNG MMP3 PRKCA KDR MMP2 CASP9 HEL-S-44 MAPK1 NOS2 IL1A LYZ FOS CXCL10 GSTM1 VEGFA RXRA PRKCB CDKN1A NR1C2 BCL2 EGF CHUK MPO RUNX2 NR3A2 EGFR TOP2A CYP1A2 CHEK2 RXRB AHR opn CRP CCND1 IL2 CD40LG CYP1A1 IL4 IL1B JUN SELE BAX IL10 MGAM OPRM1 MMP9 IGF2 CXCL2 IL6 CHEK1 HEL-S-130P NR1C1 IKBKB CASP3 HEL-S-102 NFKBIA CYP3A4 RELA RAF1 PMC6197473__F2 Snapshot of protein-protein interactions involving p85A (the “p85A network”).The binding to PTEN and to BRD7-XBP1 has a negative effect on PI3K activity (red color), the first by stabilizing PTEN, the second via p85A depletion (, , –) PTEN BRD7 XBP1 CDC42 PMC6179164__F6 Mechanisms by which IFNA disrupts thyrocytes to trigger AITDs CXCL10 TRIM21 TG PMC9652569__F1 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking NFKBIA FOS RELA TNF JUN PMC9639746__F1 Cancer immunotherapy strategies that target the cGAS-STING pathway CGAS APC COIL PMC9652569__F7 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking RELA TNF JUN PMC12141126__F2 Systemic lupus erythematosus-induced endothelial dysfunction and atherosclerosis VCAM1 CRP VWF PMC3946543__F4 A Lipidomic Perspective on Inflammatory Macrophage Eicosanoid Signaling COX2 PMC7327152__F1 Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis CCR5 CCR2 CCL21 CCL2 MYD88 IFNG STAT1 NLRP3 VCAM1 ABCG1 ABCA1 IL1B CD36 PMC8070608__F2 Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy RARA PML PLG SMAD2 TGFBR1 SMAD4 MTOR FOXC2 TGFB1 PMC8563889__F1 Ferroptosis, radiotherapy, and combination therapeutic strategies LPCAT3 SCD ATM SLC7A11 ATF4 DHFR MDM2 POR IPP NR1C1 PMC7829660__F3 Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action CD14 TLR4 LBP MYD88 TIRAP PMC9630482__F2 Extracellular vesicles as advanced therapeutics for the resolution of organ fibrosis: Current progress and future perspectives SMAD2 GSK3B SMAD4 BMP7 SMAD1 DKFZp781O1323 PMC10816780__F15 Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs VEGFC MYC BCL2 VEGFB STAT3 PMC5545727__F3 List of 24 CMMDh genes (left), genes enriched to the top canonical signaling pathways (middle) and the network of these genes with mood disorders and the CMD-Rs (right) ADRB1 CRY2 GSK3B CREB1 TCF7L2 SLC18A1 ITIH4 MTNR1B LEP POMC TLR4 IGF1 ADRA2A HTR1A REST GNAS BDNF NCAN APOE PMC7804279__F2 The Hippo pathway in the pathogenesis of inflammatory bowel disease LATS1 LATS2 TF PMC7804279__F1 The Hippo pathway in the pathogenesis of inflammatory bowel disease NF2 VGLL4 LATS1 LATS2 PMC7804279__F4 The Hippo pathway in the pathogenesis of inflammatory bowel disease VEGFA LATS1 LATS2 PMC7804279__F3 The Hippo pathway in the pathogenesis of inflammatory bowel disease SMAD2 STAT3 FOXP3 PMC8803653__F2 Rituximab in the Treatment of Interstitial Lung Diseases Related to Anti-Melanoma Differentiation-Associated Gene 5 Dermatomyositis: A Systematic Review CX3CL1 CXCR4 PMC8232320__F1 Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives CGAS RNASEH2C MVK RNASEH2B NOD2 NLRP3 IL18 TLR4 POLA1 SHARPIN TREX1 OTULIN IL1B SMS PMC3989450__F3 Wnt-dependent interactions between cardiac myocytes and cardiac fibroblasts after acute myocardial infarction SFRP4 WNT3A WNT1 SFRP1 PMC5346041__F1 Major pattern recognition receptors (PRRs) that sense RNA and DNA virus pathogen associated molecular patterns (PAMPs) in the cytosol CGAS IRF3 TRIM25 AIM2 MAVS IFI16 PMC3989450__F2 Canonical Wnt signalling APC GSK3B LRP5 LRP6 PMC4485953__F2 New Model of Reverse Cholesterol Transport: EnTICEing Strategies to Stimulate Intestinal Cholesterol Excretion PCSK9 ABCG8 ABCG5 LDLR NPC1L1 ACAT2 PMC3620567__F1 Ischemia-reperfusion injury in the diabetic myocardium is multi-factorial and complex BAD PTEN PMC10379778__F2 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin APC ARHA PTEN RAC1 FER LEF1 JUP IQGAP1 SRC HEL114 MAGI1 CDH2 CDC42 PMC10379778__F1 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin BRAF ROCK1 ATF2 SMAD2 TRAF6 CEBPB PDPK1 FZR1 GADD45B PARD6A CDC2 RPS6 SP1 JUN MAP3K1 SKIL FOS APC MAP3K7 SMAD6 MAP2K2 ARHA RAC1 TSC2 PAK1 CREBBP YY1 SOS1 SHC1 CDC42 PMC6691199__F3 Proposed pathophysiological mechanisms that could explain the presence or absence of response to treatment in myocarditis PKP2 BAG3 RYR2 IL1B PMC9405832__F1 MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male Patients DHFR PMC5638334__F10 De novo transcriptome sequencing of Isaria cateniannulata and comparative analysis of gene expression in response to heat and cold stresses ARHA CHMP3 ARF6 PMC12065808__F1 Comprehensive network featuring genetic regulation and glucose, fatty acid, and glutamine metabolism in cancer CS PC FH MYC GLS2 ACLY MTOR CD36 PMC4537692__F8 Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression TFEB PKD1 HDAC5 PMC9293965__F2 Clusters of significantly enriched biological pathways for AD and GERD TH ZNF582 DKFZp686D2168 PMC11791101__F3 Paracrine of the hedgehog signaling pathway FGF4 BOC PTCH2 KIF7 NGF FOXM1 GAS1 GAST CCND2 CCNE1 SUFU BCL2 SMO PMC11791101__F2 Autocrine of the hedgehog signaling pathway BOC FGF4 PTCH2 KIF7 FOXM1 SUFU VEGFA BCL2 SMO GAS1 CCND2 CCNE1 PMC11791101__F1 Normal activation mechanism of hedgehog signaling pathway PTCH2 KIF7 SUFU EVC2 GLI3 EVC SMO GAS1 PMC4344782__F9 Alzheimer-related protein association network in AD-iPS5 neurons SNCA NDUFS4 NDUFV2 NDUFB9 PPP3CC GSK3B NDUFB2 NDUFAB1 COXFA4 UQCRFS1 CALM1 CASP3 NDUFB7 NDUFB3 APP ATP2A2 PSENEN COX7B NDUFB6 SDHD SDHA APOE SDHB PMC6047437__F1 Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma BRAF EGFR PTEN PRIMA1 MTOR PMC4631295__F2 Canonical Wnt signaling pathway APC PMC5536816__F3 Benefits of physical exercise (PE) act through or require a healthy, functional endothelium (beige cells) COX2 VCAM1 HEL-S-44 BDNF SIRT3 PMC6985271__F1 Type-I interferon signaling and ISG15 ISG15 TYK2 IFNAR2 JAK1 IFNAR1 SKP2 USP18 PMC9025460__F1 Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways SQOR PRODH DHODH PMC5088510__F3 Proteins modified by lysine methylation from the PhosphoSitePlus database were mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) prostate cancer pathway CDK2 MDM2 GRB2 CCND1 BCL2 SRD5A2 PTEN MTOR PMC4129668__F1 Roles of PGs/GAGs on the breast cancer motile phenotype EGFR SRC PMC5342467__F9 RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation ATM DMAP1 RGS6 PMC8110983__F2 Tumour-derived factors associated with cachexia in pancreatic adenocarcinoma TH POMC TLR7 NPY UCP1 AgRP TNF MTOR IL1B STAT3 PMC10275075__F5 Population response of intestinal microbiota to acute Vibrio alginolyticus infection in half-smooth tongue sole (Cynoglossus semilaevis) FLI1 FIGN PMC7840052__F7 Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver MPV17 PXMP4 PEX16 PEX13 PEX14 PTS PEX19 PEX6 PEX2 PEX10 PEX12 PEX26 PXMP2 PMC7072125__F8 Molecular regulatory mechanism of Wnt/Beta-catenin signaling, induction of extrinsic apoptosis pathway by natural bioactive TA in NCCIT cells, and role of mROS in TRAIL-mediated extrinsic apoptosis induction with TA treatment SOX2 TRADD PMC7072296__F2 Regulatory models of the Nrf2-ARE pathway induced by arsenic KEAP1 RBX1 PMC8071157__F4 MicroRNAs involved in aromatase regulation in breast cancer TGFBR1 PMC8071157__F3 MicroRNAs involved in aromatase regulation in breast cancer NR5A2 CREB1 MTOR PMC8886228__F2 Metabolic Reprogramming, Gut Dysbiosis, and Nutrition Intervention in Canine Heart Disease CD36 HEL-S-5 PMC12227620__F8 Graphical representation of the working model DSG2 CD44 IL8RB PMC2966484__F3 Activation of the NFKB signaling pathway SKP1 RBX1 PMC6206851__F1 Cellular Mechanisms of Estrogen Action EGF FOXA1 FOS GC JUN PMC6745301__F2 MicroRNAs and Regeneration in the Animal Models of CNS Disorders RICTOR SMAD1 RHEB DKFZp781O1323 PMC6383596__F2 Effector cytokines can stimulate transcription of proinflammatory signals through the Janus kinase–signal transducers and activators of transcription (JAK-STAT) signalling pathway TYK2 JAK3 JAK1 PMC2762102__F5 Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis MCM3 MCM5 MCM6 MCM2 ATM ATRIP MCM7 ATR H2AX PCNA PMC5038225__F1 IGF-1R downstream signaling cascades IGF1R IGF1 MTOR IRS1 STAT3 PMC3553500__F7 NleB, a bacterial effector with glycosyltransferase activity targets GADPH function to inhibit NFKB activation TRADD TNF MAP3K7IP1 TRAF2 HEL-S-162eP PMC9456096__F10 Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NFKB Signaling through TLR2 and TLR4 TRAF6 MYD88 MAL PMC2909548__F4 Protein-protein interaction maps comprising the transforming growth factor B signaling pathway of transcription factors associated with liver cell proliferation GNB2 CREB3L2 CSK ATF3 DPF2 ID3 NFKBIA ATF4 FHL2 CNOT3 PTP4A1 GDI1 ZNF331 PMC2909548__F3 Protein-protein interaction comprising the transforming growth factor B signaling pathway CUL5 RHOBTB1 CHUK EFNA1 COL3A1 SQSTM1 TGFBR1 RAB33B RHPN2 RIPK2 RRAS2 UBB COL5A2 PFN1 STK35 FBXO3 TOB1 COL1A2 PLEK JUN PMC5507649__F2 Targeting the ALK signaling pathway STRN PTN ALK STAT3 PMC4516574__F5 An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells IFIT3 STAT2 IRF9 IFITM1 IFNG STAT1 OAS1 PIAS1 TYK2 JAK1 IRF-1 PSMB8 SOCS1 IFIT1 BAX PMC6799822__F7 Signaling pathways contributing to mucus production CLCA1 MUC5AC EGFR SP1 HES1 PMC6531857__F4 Regulated necrosis: disease relevance and therapeutic opportunities CTH GPX4 HEL-S-64p HEL-75 GLS PMC3862456__F3 Neutral AA transporters and activation of the mTORC1 signaling pathway TSC2 TSC1 IRS1 RHEB HEL-S-5 PMC6531857__F1 Regulated necrosis: disease relevance and therapeutic opportunities RIPK1 IL1A TRADD CYLD RIPK3 CSA2 TNF MAP3K7IP1 TRAF2 FADD MLKL PMC4204437__F1 Fanconi anemia (FA) proteins implicated in interstrand cross-link (ICL) repair SLX4 BRCA1 RAD51C PMC6913815__F1 An overview of the 3 unfolded protein response pathways ATF4 DBP EIF2A ATF3 TRAF2 XBP1 PMC8799033__F3 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer SPARC COPE COL12A1 opn COL1A1 COL4A1 PMC4938382__F2 Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas SPARC TH PCDHA1 CRHBP SORD ITK OMD SFTPC FERMT2 NPTN ACAN IL13 VCAN APC DMTN STC1 ADRB2 PPCDC BLK FAT2 GLRB FER ABAT IFNK GABRE MT1G KLF4 SYK CARTPT MT1A RORA MEGF11 GLDN FOXS1 MEF2C PCDHB1 PMC8799033__F6 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer CD47 CD44 VWF CHAD CD36 PMC7601648__F1 Canonical NFKB signalling pathway induced by TNFA and IL-1B and the role of ubiquitination USP4 RNF11 USP21 TRADD IRAK1 USP31 USP20 TRAF6 IRAK4 MYD88 USP48 TRIM23 ING4 PDLIM2 CYLD SIAH2 TRAF2 SOCS1 ITCH PMC4160340__F2 Rho-GTPases as key regulators of T lymphocyte biology PLCG1 BCL10 ARHH APC LCK VAV1 ZAP70 GRB2 RHO RAC1 LAT CDC42 PMC3730427__F8 Glucose deprivation in cancer cells activates UPR following HBP flux reduction EIF2S1 ATF4 BCL2 XBP1 PMC4601190__F2 Epithelial cell recognition and discrimination of Candida albicans yeast and hyphae MTOR TF PMC11586749__F6 Analysis of classical signaling pathways and immune infiltration MYB ZBTB7A NRF1 ASCL1 ATF2 MYC SFPQ CREB1 TCF12 HIF1A SOX9 STAT1 FGFR1 NR1i1 TBP CCR7 EZH2 SP1 IRF-1 NR1H2 FLI1 TCF3 RFX5 TP63 TCF7L2 JARID2 CDK8 tal-1 MAX NFKB2 MAFK YY1 CDK9 ACTG1 BRD4 SUMO2 PGR FOXM1 SETD1A CTCF POU2F2 CDK7 CEBPB CXXC1 AHR FOXA1 CNOT3 TFAP2A IRF4 NFYB KLF1 NFYA NR3C1 CHD2 HDAC1 RCOR1 BCL6 EED FOXA2 CREBBP EP300 TRIM28 TRIM24 E2F6 RUNX1T1 SNAI2 NR2F1 CBFB BATF SMC1A ASXL1 TAF3 RAD21 BHLHB2 RUNX3 HCFC1 ERG FOS CEBPA LMNA FOXO1 BCOR KMT2A CHD8 KLF4 ZNF143 GABPA PBX3 MLL2 SUPT5H TFAP4 TLE3 PRDM11 LEO1 RARA MBD3 BPTF MED1 DDX5 NIPBL JUN KDM1A TAF1 EGR1 LARP7 SP2 PBX1 TRIM25 GATA2 SMC3 NFKB1 TFAP2C KDM4C SMAD1 KDM4A TCF4 STAT3 PMC7609400__F2 Extrinsic function of the PD-1/PD-L1 signaling axis in cancer APC LCK ZAP70 IL2 CD80 LAT PMC7444376__F3 GCN5 enhances the osteogenic differentiation of PDLSCs KREMEN1 LRP5 LRP6 DKK1 PMC10571700__F5 Gene expression (CAMs) PIK3CD BATF3 EGF BATF2 CNTN1 ALK CD6 EGFR NRXN2 NRXN3 SPN IFNG CDH2 CD3G ICOS CD3E CD3D NCAM2 FOS NRCAM NGL1 CTLA4 TIGIT CD8A ITGAM NFATC2 ITGB8 CNTN2 LCK ZAP70 SELP LAT NFKBIE AKT3 PDCD1 PMC8557044__F1 Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury GPX4 LPCAT3 STEAP3 SLC7A11 PMC7477662__F1 Main signaling pathways regulating autophagy TSC2 TSC1 PTEN PMC7659517__F2 Schematic view of M1 and M2 macrophage metabolism.Left side, M1 macrophage triggers a pro-inflammatory response ATF3 ACLY MTOR CD36 GLS PMC7659517__F1 Warburg effect likely supports replication of SARS CoV2 in airway cells.Enhanced aerobic glycolysis sustains the replication of many viruses in a similar way to the Warburg effect ACLY ACE2 HEL-S-133P GLA PMC6761220__F3 Strategies for immunomodulation to mitigate periprosthetic osteolysis induced by wear particles CD163 MYD88 ARG1 IL1B PMC4373664__F1 Canonical Rho GTPase signaling motifs regulate actin cytoskeletal dynamics DAAM1 PAK1 ARHA RAC1 FMNL1 CDC42 PMC4644376__F12 Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression AREG EGFR LATS1 TGFA LATS2 PMC6664079__F3 Potential targets for immune modulation during chronic progression of implant-related bone infections CTLA4 TIGIT LAG3 PMC10910037__F2 Crosstalk between NFKB signaling and other signaling pathways TLR4 APC LYN IL7R SYK MYD88 CD79A PMC5285449__F1 Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis NOTCH2 AMOT NF2 SCRIB LATS1 RHO LATS2 PMC5422478__F4 Autoantibodies in the pathogenesis of Graves’ orbitopathy IGF1R IGF1 TSHR CD40 TNF MTOR IRS1 PMC7881399__F3 Sub-network including 12 hub-bottleneck nodes and two seeds of clusters 1 and 2 MUC5AC ALB PTGS2 EGFR VEGFA INS CXCL8 IL6 IL4 TNF GCG PMC7881399__F6 Action relationships including activation (green), inhibition (red), expression (yellow), and binding (blue) between the genes which were related to the determined biochemical pathways MUC5AC ALB EGFR VEGFA INS CXCL8 TNF PMC7881399__F5 Results of biochemical pathway analysis of hub-bottlenecks plus seeds of cluster-1 and 2 via ClueGO+CluePedia analysis MUC5AC ALB PTGS2 EGFR VEGFA INS CXCL8 PMC5858916__F7 Rotavirus infection TBK1 STAT1 BTRC STAT2 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC5341901__F4 On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer HEL-S-26 ERBB2 FH MYC HIF1A GLS PMC5898751__F6 Phytohormone and MAPK signaling pathway MAPK6 TF PMC6539695__F7 EGF and TPA mediated pathway to phosphorylate serines in the SCFBTRCP recognition site of PDCD4-protein in Huh7 hepatoma cells EGF MTOR PMC7544845__F6 Druggable signaling cascades in vasculitogenic T cells ZAP70 NOTCH1 IL2 PTEN HES1 PMC7544845__F5 NOTCH signaling pathway in giant cell arteritis NOTCH1 HES1 PMC11872466__F10 KEGG pathway enrichment analyses of screened compounds in the treatment of AD TH NUMB BAD INS NRARP MTOR HES1 HES5 COX2 NOG LPL APP CASP9 ATG14 SNCA CASP12 TUBB RTN4 APC LRP5 CDK5 NRBF2 MCU TNF CASP3 FADD PMC11567945__F1 Alterations of paracellular permeability in Alzheimer's disease (AD) patients and numerous AD models MMP9 ARHA AQP4 PMC4075250__F5 Ingenuity network analysis of differentially regulated labeled-pairs SNCA MBP GDA MYC CNP LPO ARF1 SYT1 HEL-S-69p SLC2A4 GRIN2B MAPK1 HEL-S-133P PMC5404269__F8 CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue CYP2J2 ARG1 JUN PMC5321202__F1 CORM-2 influences IBA-1- and GFAP-positive cells and many nociceptive factors and signaling pathways as measured on day 7 after CCI IL10 NLRP3 TIMP1 IL18BP PMC6539695__F4 Pathways of EGF mediated protein synthesis and PDCD4 degradation EIF4E MTOR PMC7862811__F1 PI3K/AKT signaling pathway activation and potential functions of LAPTM4B in cancers LAPTM4B CREB1 CCND1 PMC3402681__F1 Proposed mechanistic model on how SHARPIN regulates TNF-induced NFKB activation through linear ubiquitination-mediated mechanisms TRADD RELA SHARPIN TNF TRAF2 TAB3 PMC6212953__F1 Hepatitis C Virus (HCV)-induced oncogenic signaling SRCAP SOCS3 SMAD2 APC EGFR SMAD4 STAT3 PMC7881399__F2 Cluster-2 including 19 nodes and 111 edges CCK CALCA NPS S100A8 INS PPY TSLP GCG GAST MLN PMC7881399__F1 Cluster-1 including 24 nodes and 176 edges LEP TLR4 CCL11 GPT PTGS2 EGFR VEGFA CXCL8 CCND1 PYY CDKN2A VIP PMC8635784__F5 Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NFKB Signaling Pathway TLR4 IRAK1 IRAK4 MYD88 PMC2577715__F15 Notch, Wnt, and SHH signaling pathways APC GLI3 SHH SMO PMC7701056__F1 PI3K/Akt/mTOR pathway TSC2 TSC1 PDK2 PTEN DEPTOR RHEB PMC4102824__F1 Flow diagram of the monoamine neurotransmitter biosynthesis pathway SPR TH PNMT DBH MPG PMC6386234__F1 Molecular pathways of cellular senescence ATM CDK2 MDM2 CDK4 CDC2 MTOR ATR PMC4588145__F1 Fish nucleic acid PRR signaling pathways TBK1 TLR8 TLR7 TLR9 IRF7 DDX41 IRF3 MYD88 TLR3 PMC7346763__F2 The transmembrane receptors for CSPGs and myelin-associated inhibitors and the signaling pathways downstream of two receptor protein tyrosine phosphatases (RPTPs) MAP1B APC ARHA PMC4348434__F2 Oxidative Krebs cycle CS PC CPT2 GLS PMC4098898__F2 Glutamate Metabolism and HIV-Associated Neurocognitive Disorders STAT1 PI3 IL16 CXCR4 PMC2864663__F5 Aging-related upregulation of NFKB signaling in VSMC VCAM1 RELB PMC2864663__F4 Aging-related upregulation of AP-1 signaling in VSMC FOS JUN PCNA PMC4685044__F1 Signaling pathways activated by cytokine receptor binding MYC STAT3 PMC5147022__F1 MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis AGO1 AGO2 DGCR8 DICER1 AGO4 DROSHA RAN PMC2930664__F1 One-Carbon Metabolism and Alzheimer’s Disease: Focus on Epigenetics RFC1 MTR MTRR TYMS PMC3518570__F2 Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease BMP2 FGF2 GDNF BDNF PMC6859457__F7 The HPV18 pathway regulates Tim-3/galectin-9 through EZH2-H2K27me3-DNMT3A LGALS9 HAVCR2 EZH2 PMC8042688__F1 Biological interactions among the formaldehyde-related genes, a hematological malignancies, and b cell processes EPOR EPO MPO F2R PTEN CCL2 HMOX1 IFNG GSTT1 IL18 TLR4 ATM MDM2 IL17A IL2 PRF1 B2M IL4 H2AX IL1B BAX IL10 PTGS2 VEGFA PARP1 IL6 TNF HRAS HEL-S-22 CASP3 CDKN1A TNFSF11 VCAM1 IL3 BCL2 CD40 TGFB1 PMC4623426__F4 Regulation of Janus activated kinase (JAK)-Stat and nuclear factor kappa B (NFKB) signaling by TGFB through MKP-1 STAT1 TRADD SMAD2 TRAF2 TF PMC4623426__F3 Transforming growth factor B (TGFB) signaling pathways and aging SMAD2 SMAD4 TF PMC4623426__F5 Reciprocal regulation of TGFB and Jak-Stat signaling STAT1 TF IFNG PMC11643850__F4 Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases COX2 ATF4 XBP1 PMC11643850__F3 Signaling of Wnt and calcium ions through MCOLN: CUR can activate Wnt signaling way by increasing the stability of Beta-cyclin, leading to its accumulation in the cytoplasm TFEB APC MYC PMC11643850__F2 Signaling pathways for the neuroprotective effects of CAP and CB: CAP acts on TRPV1 and activates the PI3K/AKT/mTOR signaling pathway, enhances the phagocytosis of microglia, and activates the promoter of BDNF MTOR BDNF TRPV1 PMC4222256__F8 Supposed mechanism of EVE-induced EMT TSC2 RICTOR TSC1 PRR5 MTOR HPSE RHEB MLST8 PMC3108840__F7 Functional pathway analysis of glycoproteins overexpressed in PC3-ML2 INA SLC14A2 JUP POSTN PCDHJ PNN hEMMPRIN MAVS HACL2 PMC3108840__F6 Functional pathway analysis of glycoproteins overexpressed in PC3-N2 SEC24C HM13 STT3A NUP188 RNF213 CTNND1 PRPF40A CD55 PALM LCP1 TEX10 PMC6689970__F1 Schematic overview of NAD biosynthesis pathways NAPRT NAMPT NNMT NRK PMC9554879__F5 Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM SET INS ELL PMC2270353__F4 NPTX2 pathway obtained by means of the Resnet 5.0 eukaryotic database of molecular interactions (Ariadne) overlayed with microarray expression values NPTXR NPTX2 GRIA3 GRIA4 NPTX1 GRIA2 PMC6114477__F1 Tumor-associated macrophages and epithelial-to-mesenchymal transition in hepatocellular carcinoma EGF CXCR1 SMAD2 MMP9 GSK3B SMAD4 NTS ARHA FOXC1 HNF4A ZEB2 CDH2 STAT3 CDC42 PMC4784721__F1 Major AGTR1 signalling pathways linked to cancer cell proliferation, angiogenesis and EMT BCL10 EGFR GRB2 PMC6114477__F5 Virus-related products in the inflammatory tumor microenvironment COX2 IGF2 MMP9 GSK3B STAT3 PMC6114477__F4 Inflammatory mediators in hepatocellular carcinoma CXCL1 PI3 LOXL2 MMP2 SMAD2 CXCL10 MMP9 MMP16 PMC9214699__F5 Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma PIK3CD PIK3R1 SOCS2 PRKCZ MAPK9 SOCS3 PCK1 ACACA MAPK3 PRKAR1A PRKAA1 PHKA2 PYGB EIF4EBP1 CRKL PPARGC1A ACACB PCK2 RPS6 PRKAG1 PRKAB1 PRKCI FBP1 HRAS ID1 FOXO1 RHEB CALM1 PPP1CC HEL-S-80p MAP2K1 PRKAG2 PIK3R2 PMC6214858__F7 Schematic flow diagram of signal transmission from regulatory factors secreted by TM4 cells to ADSCs EGF SOX2 MDM2 TGFB1 ELL PMC5508315__F2 Direct, indirect and semidirect pathway of allorecognition APC CD44 PMC6747268__F4 Signaling pathways involved in the switch between proliferation and dormancy CDK4 MTOR RHEB PMC5508315__F1 Mechanism of regulatory T cell (Treg) suppression IL10 APC CD80 PMC8569813__F2 Colon Cancer Progression Is Reflected to Monotonic Differentiation in Gene Expression and Pathway Deregulation Facilitating Stage–specific Drug Repurposing TACSTD2 PPARGC1A CLCA1 F2 SLC26A2 TMEPAI PMC9379408__F10 Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells GLTPD1 SP1 SP3 PMC11793009__F9 Potential regulation loop of MET and ETS collaboration HGF AREG CXCR4 PMC5506222__F4 Schematic model showing AA sensing signaling pathways that might modulate neuronal activity of central olfactory areas SLC7A5 CASR SLC12A5 SLC3A2 TRPM5 PMC6289335__F1 Molecular actions of CTLA-4 and PD-1 on inhibiting T cell function PPA2 CD80 PTEN MTOR PMC6877505__F1 Schematic view of microglial activation and cross-talks between microglia and other immune factors in the pathogenesis of Parkinson’s disease SOCS3 IGF1 CCL20 CCL2 BDNF IL1B PMC3191464__F2 Model depicting the pathway of TGFBeta-mediated Bim regulation and apoptosis RUNX1 FOXO3A SMAD4 PMC8672524__F7 Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction INCENP CCNB1 ZWINT KNTC1 CENPA PMC2727921__F1 Genetic polymorphisms, their allele combinations and IFNB treatment response in Irish multiple sclerosis patients STAT2 EBI3 IRF9 IFNGR2 IFNAR1 IL23R IL12RB1 PNPT1 IL10RB STAT1 PRKCA CASP3 LEP GBP1 PIAS1 TYK2 IFNGR1 IL10RA PMC6420874__F1 Mechanisms by which radiation enhances immunotherapy HMGB1 SIRPA CGAS CD47 PMC3122316__F1 F igure 1.— ADSL HEL-S-70p PMC8495383__F3 Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment ELF2 TLR4 ERBB2 MAPK7 ENO1 PIGR MEF2C PMC4223001__F1 Harnessing Hippo in the heart: Hippo/YAP1 signaling and applications to heart regeneration and rejuvenation AMOT NF2 SRC RHO LPA PMC7312732__F6 Activation of the TRPV1 ligand-gated ion channel and subsequent [Ca2+]i and protein signaling influence the balance between proliferation and apoptosis NGF ATM ATF4 EGFR UNK RAC1 XBP1 TRPV1 PMC6769685__F5 Apoptotic pathways triggered by inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors SRC MTOR PMC7407888__F1 Scheme illustrating the IL-10 signaling pathway SOCS3 TYK2 STAT3 PMC9478028__F3 Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure CCNA2 SET ESPL1 TERT CCNE1 PMC3396155__F5 The balance in signalling through either ALK-1 or ALK-5 regulates leptin expression in MSC SMAD2 SMAD1 DKFZp781O1323 PMC7312732__F2 TRPV1 induces proliferation through Ca2+ entry, ATP release and membrane P2Y2 receptor activation, and the transactivation of epidermal growth factor receptor (EGFR) PDK2 EGFR SRC TRPV1 PMC8583859__F2 Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy NLRP3 COX2 TLR4 IL1B CD36 PMC8531643__F1 Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities JMJD4 SUV39H1 MTOR FASN PMC7518150__F5 Molecular mechanism of Wnt/Beta-catenin signaling pathway activation APC GSK3B LRP5 LRP6 PMC3918842__F2 Pathways for the synthesis of phospholipids and their interconnection PC PCYT2 PSD PEMT PMC5828202__F10 Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway ATF4 EIF2A SP1 PMC5468621__F5 Summary of signaling events and downstream transcription factors driving specification of the blood stem cell lineage ETV2 NOTCH1 HHEX GATA2 PMC8964100__F8 Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway BLM COL1A1 STAT3 PMC6093060__F7 NFKB inflammatory signaling pathway IL16 TLR4 MYD88 PMC8876671__F3 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance SALL4 MAML1 SOX2 HEY2 MEIS1 NOTCH3 HES1 PMC5481366__F1 Estrogen biosynthesis HSD17B12 STS SULT1E1 HSD17B1 HSD17B2 HSD17B7 HSD17B8 PMC3875949__F1 Regulation of metabolism in maligant gliomas EGFR ACLY HK2 HEL-S-162eP GLS PMC5811730__F4 Distinct mechanisms of small-molecule inhibitors and monoclonal antibodies for targeting receptor tyrosine kinases in cancer cells EGF EGFR GRB2 CR2 CR1 PMC8666372__F3 Activated and inactivated canonical Wnt signaling APC LRP5 LRP6 DKK1 WIF1 SFRP5 PMC5811730__F3 Rationale for targeting both the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways for suppressing cancer growth BAD EGFR MDM2 GRB2 SHE MTOR RAI1 PMC8666372__F1 Activated and inactivated canonical Wnt signaling APC LRP5 LRP6 PMC8876671__F2 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance SALL4 BMI1 PTEN PMC8876671__F1 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance SALL4 WNT3A TRIB3 CCND1 BMI1 AXIN2 TCF4 PMC8231959__F1 Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors FDX1 COQ3 FDX2 COQ2 COQ6 COQ5 RHO IPP COQ7 FDXR PMC3342071__F2 FcERI signaling events in WT, NTAL−/−, and LAT−/− cells GAB2 LYN GRB2 LAT PMC8920690__F1 Nervous System Contributes to the Tumorigenesis and Progression of Human Digestive Tract Cancer IGF1R SRC PMC5905346__F1 GCs stimulate GSK3ß and inhibit Wnt signaling APC GSK3B LRP5 LRP6 PMC7927137__F5 Circadian clock machinery regulates the biosynthesis of NAD+ through control of the NAD+ salvage pathway NAMPT SIRT1 PMC2744278__F3 Phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways BAD GSK3B MDM2 GRB2 PTEN MTOR PMC6041767__F2 Example module (L1) more densely connected in ER- group with red nodes indicate genes belonging to the immune response pathway PROS1 APOL3 FCGR2A GEM LAT2 SAMSN1 ALOX5 SPRY1 CD83 SLIT2 HLA-DMA CXCL13 FBLN5 IGSF6 BACH2 CFH SFRP1 PTPN6 C1S RASSF2 CD3E ANXA1 ITM2A TMEM100 VAV1 SPARCL1 FXYD1 CD69 IL33 CLEC10A HEL113 DPT PSMB10 HEL-S-81p PMC2830970__F1 Schematics of the retroviral replication cycle CCR5 CXCR4 PMC6084457__F1 Metabolic pathways contributing to HSC self-renewal and differentiation HEL-S-26 VIT BCAT1 PTPMT1 MYC CPT2 HEL-S-133P HEL-S-5 PMC10138908__F7 Which OBHS remodels abnormal glycometabolism, referring the experiment results ENO1 HEL-S-68p PMC6782151__F11 Mechanism of microglial activation by fibrillarBA and PrP peptides responsible for neurotoxicity LYN GRB2 SYK PMC1134761__F4 Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit APC NET1 CA4 PMC7281073__F1 PI3K/AKT/mTOR pathway activation leads to cell growth, increased protein synthesis, inhibited apoptosis, cell cycle progression and proliferation BAD FANCD2 EGFR MDM2 CCND1 PTEN BAX PMC3625357__F11 IPA-generated gene network linking 88 of 445 genes shown by microarray analysis to be significantly (P < 0.01) up- (blue) or down- (red) regulated >twofold in bovine TCs in response to BMP6 treatment MYB FOXO4 FBLN2 SNAI2 CCL5 SERPINA3 FGFR2 GPAM HES1 FBLN5 HPGD CDH2 NOS2 ECE1 SERPINB2 HEL-S-133P BHLHB2 AKAP12 PLAUR ANGPTL4 HSD3B1 TES VCAN VEGFA INSL3 HMGCS1 NCAM1 KRT18 EDN1 PLAGL1 EDNRA NEDD9 CCL20 KLF4 RND1 ABCA1 BEX2 ARFGAP3 NR5A1 CLEC3B HEL-S-101 DHCR24 AKAP5 PLAT SHBG NGFR LTBP2 ZBTB16 TM4SF1 IL1B STAR FASN PTGS2 CYP11A1 IL6 ID1 SERPINE2 ID3 ADAMTS4 GIG8 MGST1 MRC2 INHA LHCGR BNIP3 PMC10383966__F4 Pellino Proteins in Viral Immunity and Pathogenesis IRF7 IRAK1 IRF3 IRAK4 MYD88 PMC5445144__F4 Regulatory T cell (Treg) action mechanisms CD80 CTLA4 LAG3 PMC10383966__F1 Pellino Proteins in Viral Immunity and Pathogenesis TBK1 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 GSDMD TAB3 PMC7473936__F12 Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure HEL70 PAK1 LIMK1 RAC3 RHOV ARHA RHO RAC1 RHOB CDC42 DMPK PMC7246454__F1 DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension ATM TOPBP1 ATR BRCA1 PMC3248879__F1 Network images of FTO and candidates genes USP2 NICN1 CAMK2G PPP2R1A PTEN SSBP2 PREPL CBX6 GLRB USP34 CDR2 VAMP2 PFN2 NLN KIF3C NTRK2 STX12 PMC9680067__F4 Teleost NOD-like receptors and their downstream signaling pathways: A brief review NLRP3 VEGFA TRAF6 MTOR NLRC3 STAT3 PMC3248879__F4 In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway EGR1 EGR2 FOS BDNF CEBPB PMC9680067__F6 Teleost NOD-like receptors and their downstream signaling pathways: A brief review NLRP3 IL18 LTA NLRP1 NLRP12 NLRP6 IL1B PMC9680067__F3 Teleost NOD-like receptors and their downstream signaling pathways: A brief review NOD1 IRF7 IRF3 NOD2 MAVS PMC8339999__F9 Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NFKB Axis TH NLRP3 MYD88 PMC4468292__F1 Influence of the inflammatory cytokines on the status of insulin resistance TLR4 IRS1 STAT3 PMC5704542__F8 Model for regulation of nitrogen availability response RPS6 EIF4B PMC9483726__F3 Comprehensive elaboration of circular RNA in multiple myeloma MAPK4 ABCG2 ATG14 HDAC1 CDK6 SKP2 AKT3 BRD4 PMC2824707__F1 Tissue level and signalling pathways for PGE2 is presented COX1 EGFR PMC5207147__F13 Proposed model on the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1signaling axis in HGF-mediated lamellipodia formation HGF SPHK1 SPNS2 PMC4373397__F2 Mucosal barrier integrity and inflammation IL33 CCL2 IL25 TSLP IL1B MLN PMC4440219__F7 MiR-503 mediates constitutive suppression of the IGF-1R pathway leading to a less aggressive glioma phenotype BAD IGF1R CCND1 CCNE1 PMC8256367__F3 How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us TMC1 TMC2 TMIE PMC8608616__F4 Redox regulation of DUBs and its therapeutic implications in cancer TSC2 USP19 CYLD IGF2 USP28 PTEN USP11 TGFA IL1B PHLPP1 STAT3 USP1 PMC3460412__F1 Activation of p38 MAPK downstrem of TNFR1 TRADD TRAF5 TNF TRAF2 PMC1867237__F3 ErbB/Ras pathway and Wnt pathway ERBB2 APC GSK3B MYC WNT10B DVL1 PMC4872445__F2 Distinct roles of enzymes MTHFD1L and MTHFR in the folate-related one-carbon cycle MTHFD1 MTHFD1L PMC6028513__F2 TRIMming TGFB signals in Th17 cells SMAD2 SMAD4 FOXP3 PMC5488350__F1 The Taste of Caffeine PLCB2 CALHM1 TRPM5 PMC2886325__F3 PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL) TSC2 EGF TSC1 IGF1 PTEN MTOR PMC3319521__F1 The CD47-SIRPA Pathway in Cancer Immune Evasion and Potential Therapeutic Implications SIRPA CD47 PMC4971811__F7 Proposed model for increased IL-6 and leptin production caused by global Zip14 deletion TLR4 TRAF6 IL6 MYD88 TIRAP STAT3 PMC8396208__F3 GDF15 and Cardiac Cells: Current Concepts and New Insights FOXO3A GDF15 MSC PMC8396208__F2 GDF15 and Cardiac Cells: Current Concepts and New Insights FGF21 ALK BMP2 GDF15 MSC CREB1 GFRAL OPA1 PMC4940573__F1 Strategies for modulating the BMP pathway SMURF1 SMAD1 DKFZp781O1323 PMC3875463__F1 MTOR pathway and epilepsy PIK3CA PTEN EIF4E RHEB AKT3 PMC7751413__F1 P53 signaling pathway of the large yellow croaker (Larimichthys crocea) responds to acute cold stress: evidence via spatiotemporal expression analysis of p53, p21, MDM2, IGF-1, Gadd45, Fas, and Akt TSC2 SIAH1 MDM2 CDK4 PTEN MTOR CASP8 CDK6 RFWD2 PMC5217378__F6 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.25 Gy of 48Ti ions EPGN GPR37L1 EIF4EBP3 SUPT20H INS GBP5 KRT34 PPT2 EIF4E VAMP5 RB1 KRT75 TNFSF11 GRB2 DUSP8 NRG4 LAD1 DUSP7 PMC9136582__F1 Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy ATF2 GRB2 RHO MEF2C TAOK1 TAOK2 PMC4295939__F8 Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3 PC ATM PNKP BAX PMC5217378__F7 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.5 Gy of 48Ti ions HEL-S-2a NOP56 RPL38 RPL35 RPL6 SND1 CCNE1 PMC2665873__F1 Fatty acid synthesis pathways in C FAT2 FAT1 FAT3 FAT4 PMC5217378__F2 Ingenuity Pathway Analysis showing the top molecular Network in HSPC-derived myeloid cells collected at 1 week after exposure of mice to 0.1 Gy of 48Ti ions PRR12 VPS13D CNDP2 TIMCC TSFM SF3B5 TMEM85 NDUFC2 HINT2 COLGALT1 GSDMD NCLN TMED7 DMXL1 UBC ZNF407 TMX4 NAA38 GORASP2 NANS NOMO1 ADPGK ABRACL PMC6747541__F3 Syntenin-mediated signaling in the regulation of membrane structure and cell motility MMP2 CD63 CD6 SRC ARHA CDC42 PMC6890838__F3 Mutant proteasomes from CANDLE/PRAAS subjects have a potential pro-inflammatory potential due to the negative impact they exert on mTORC1 TBK1 ATF4 EIF2A IRF3 SESN2 DEPTOR PMC6890838__F2 Defective proteasomes in CANDLE/PRAAS subjects provoke ER stress and trigger the so-called unfolded protein response (UPR) which is associated with inflammation TBK1 ATF4 EIF2A IRF3 MAVS PMC9618966__F6 Macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer LTA FOS MYC IRF3 RAC1 MYD88 JUN TLR3 MVP PMC3095999__F2 Literature-based connections among genes in altered modules of head and neck squamous cell carcinoma (HNSCC) AREG POSTN MMP9 EGFR CCL20 MYC SPHK1 SERPINA3 IL1B INHBA PMC7321691__F1 RT activates the IFNs-JAK/STAT1 pathway in cancer cells IFIT3 PLSCR1 IFIT2 IFIT5 EN2 IFITM1 MX2 USP18 MX1 IFNG STAT1 OAS1 EN1 IRF-1 JUN ENO3 STAT2 FOS IRF9 CXCL10 ENO1 HEL-S-87p IFI27 IFI44 CXCL9 ENO2 TYK2 JAK1 IFIT1 ALDH2 PMC8268006__F1 Beyond RAS and BRAF: HER2, a New Actionable Oncotarget in Advanced Colorectal Cancer BRAF EGFR PIK3CA MTOR STAT3 PMC5078854__F1 Metabolic pathway of citrate and isocitrate on the citric acid cycle in the mitochondrial matrix and in the cytosol HEL-S-26 ACO2 HEL60 PMC6363433__F2 Folate decomposition and damage repair SHMT1 DHFR HEL-S-70p MTHFS PMC11074409__F2 Activity of probiotics, synbiotics and postbiotics IL10 COX2 BCL2 IL6 IL4 IFNG BAX PMC2577687__F1 Metabolic scheme PC CIT MAL PMC11731763__F9 Signaling pathway of LH resist apoptosis and promote proliferation of freeze-thaw folliculars and granulosa cells by TGFB and its superfamily members BMP15 GPR49 FOXL2 PMC3375400__F1 Comparison of the pathways responsible for the anti-apoptotic and pro-apoptotic effects of immune complexes containing oxidized LDL (oxLDL-IC) and malondialdehyde-modified LDL (MDA-LDL-IC) BAD SYK CD36 PMC7555004__F3 Some proposed mechanisms of aging involving xanthine oxidoreductase (XOR) and its products NLRP3 ATM CDC2 MTOR IL1B SIRT1 PMC8533761__F1 Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? F2 PDK4 PMC11970819__F1 Pathophysiology and emerging therapeutic targets of IBD IL21R RUNX3 APC IL23R PMC2613125__F6 Interleukin-6 and Neural Stem Cells: More Than Gliogenesis CNTF EGF NGF BDNF PMC8059031__F3 ncRNA regulatory network map of acute myocardial infarction TUG1 PMC2528847__F2 Integration of genomic and nongenomic/rapid ER signaling and its crosstalk with growth factor receptor and cell kinase pathways in endocrine resistance: a working model EGFR HBEGF TF PMC4157971__F7 Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1–NFKB pathway in BMP-2 expression TLR4 BMP2 NOTCH1 PMC7191956__F5 Tomatidine-targeted genes-related part of the top five shared KEGG pathways MAP2K1 MAP2 RPS6KA1 FOS RPS6KA2 BOLL PMC7388413__F1 The PI3K pathway in cancer cells PI3 EGFR MTOR PMC7312293__F2 Key negative and positive regulators for NLRP3 inflammasome SPTLC1 NLRP3 PC CPT1A GPR132 NOX4 HEL-S-104 UCP2 PMC9248759__F6 Is Estrogen a Missing Culprit in Thyroid Eye Disease? Sex Steroid Hormone Homeostasis Is Key to Other Fibrogenic Autoimmune Diseases – Why Not This One? IGF1R IGF1 PMC8787213__F2 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale XK FRK UGDH UXS1 PMC4415653__F6 Genetic regulatory network based on published interactions ATF4 RELA SP1 RXRA PMC8787213__F1 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale MVK UGT8 IPP PMC5715731__F9 Model illustrating the intracellular signaling pathway leading to cell proliferation and survival in response to NRG-1B treatment ERBB2 ERBB3 GSK3B BDNF PMC8115506__F1 Excess levels of cytoplasmic TDP-43 lead to mitochondrial penetration of TDP-43 which may trigger mtDNA release with ensuing activation of the cGAS/STING immune sensor TBK1 CGAS F2 IRF3 TNF PMC7768821__F9 Possible mechanism(s) of suppression of alcoholic hepatosteatosis by physcion NLRP3 IL1B NR1C1 PMC4415653__F3 SP1, JUN and STAT1 subnetwork from the Brown module STAT1 COPS5 ATF4 WDHD1 TPM3 NACA SP1 JUN PMC6517835__F9 Foxi3 inhibits epithelial differentiation and promotes suprabasal cell formation NOTCH2 FOXI3 SFRP5 PMC7054714__F5 Immune Responses to Viral Gene Therapy Vectors HEL-S-62p CGAS MTOR IL1B PMC8801025__F3 Organoids to model the endometrium: implantation and beyond EGF WNT3A FGF10 PMC7054714__F3 Immune Responses to Viral Gene Therapy Vectors PDC TLR9 CD40 CD80 MYD88 IFNAR1 IL1B IFNG PMC6633015__F8 The signaling pathway mediated by GABAB receptor in CGN neuroprotection PI3 IGF1R IGF1 SRC PMC6123661__F8 Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models TIAM1 FUZ RAC1 PMC3138369__F1 Signaling pathway for epidermal growth factor receptor (EGFR) EGFR GRB2 KIN PTEN MTOR PMC4322317__F6 Protein Complex Discovery by Interaction Filtering from Protein Interaction Networks Using Mutual Rank Coexpression and Sequence Similarity IP6K1 SMPD4 EXOSC5 ZNF558 EXOSC3 LRRC8D EXOSC1 NUP160 EXOSC4 DIS3 PMC8615581__F2 Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies GPX4 LPCAT3 FACL4 KEAP1 IPP PMC9375325__F2 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers BAD AGK GSK3B PTEN EFNA3 FBXW7 FOXO1 PDPK1 ITGB4 LTBP2 CDH2 LAMC2 BAX PMC6887790__F4 Biochemical pathway in neutrophils showing the signaling cascade and the effects related to DAG and PA activation CXCR1 CXCL8 IL8RB PMC9375325__F1 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers ATF2 GSK3B PTEN MTOR DEPTOR RHEB MLST8 TSC2 TSC1 MMP2 MDM2 CDH2 BAX PMC4151153__F2 Toll-like receptor 4 (TLR4) signaling pathway by Lactobacillus casei OLL2768, Bifidobacterium adolescentis MCC-75, and Bifidobacterium adolescentis ATCC15705 in bovine intestinal epithelial epitheliocytes (BIE cells) CD14 TLR4 FOS SIGIRR IRAK2 IL4 JUN PMC7297493__F1 Schematic representation of the hypothesized downstream pathways to ASCL1 and MYT1L during transdifferentiation ASCL1 MYT1L KMT2B PMC2691592__F7 Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis HUS1 CLK2 PMC9167730__F3 TLR-dependent signaling pathways are modulated by allosteric activation of CD11b FOXO3A SRC SYK IRF3 MYD88 PMC9322956__F1 Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century ERBB2 ERBB3 GRB2 SRC IRS1 STAT3 PMC3156870__F1 Resistance to RAF inhibitors in melanoma IGF1R BRAF CCND1 PTEN BMF AKT3 PMC7415163__F1 Complement activation pathways and narsoplimab mechanism of action HEL-S-62p C1S PMC11790847__F1 Multiple post-transcriptional modifications regulate cancer progression via manipulating the activity of the Hippo signalling pathway YTHDF2 USP12 METTL3 LATS1 LATS2 B4GALT1 PMC10312162__F4 Changes in the metabolic pathways of young and old leaves in the two soybean ecotypes MALL F2 PMC3534236__F3 Autophagy and selective deployment of Atg proteins in antiviral defense TLR7 TLR9 TLR1 DKFZp686F0183 TLR3 PMC11853365__F1 Multifaceted roles of ApoE4-induced Glial dysfunction in Alzheimer’s disease pathology NLRP3 IL6 PMC7244030__F8 LOC646616/miR-637/WNT3 ceRNA network in EH WNT3 CAMK2N2 PMC7243138__F2 Pin1-mediated APP processing PIN1 GSK3B APP PMC6755804__F4 Selection of enriched pathways and genes and their involvement in various tumorigenic pathways FOXO4 NGF RANBP2 CD74 SATB1 S100A14 FOSB SMO CXCL14 LAMC2 FDXR ZNRF3 ARHGEF4 NPY1R PSAP RBX1 STAG2 HEL-S-22 TIAM1 HTRA1 RASSF1 BRD3 CTCFL PTCH1 DMBT1 COL9A3 TERT CXCL1 OSGIN1 BRWD3 ARMCX1 LDB1 EGFR P4HA1 LFNG RHO MTOR HIVEP1 WDR11 NGFR DPPA2 TRIP11 PITX1 DHRS3 ETS2 RASSF2 FRAT2 GATA3 RPRM NR1C1 CNTRL MAP3K8 PPARG PMC12071403__F6 Correlation between stress-mediated inflammation and major depression SLA EIF4EBP2 PRKAA1 CYP24A1 UGT8 MTOR RPS26 HDAC1 DDIT4 ID3 IL3 ZNF729 NTRK2 PMC6349770__F2 Implementation of metabolic engineering strategies in S XDH HEL-S-162eP PMC9363121__F7 Possible model of Banp functions in stalled fork recovery, DNA damage repair, and chromosome segregation during mitosis ATM WRNIP1 NCAPG ATR BANP PMC12071403__F4 Inflammatory Factors: A Key Contributor to Stress-Induced Major Depressive Disorder PLCG1 BCL10 TRAF5 TRAF1 TRAF3 LTB RELB TRAF6 TRAF2 TRAF4 PMC5550428__F6 Regulation of ΔF508 CFTR stability by inhibitors to the PI3K/Akt/mTOR pathway BAG3 HSF1 CFTR PMC6755804__F5 Network of pathways and genes induced by P152Lp53 expression GOLGB1 NGF EGFR PSAP RHO MTOR FRAT2 RAMP2 RASGRP4 PMC7467273__F2 Genome-wide analysis of DNA methylation in testis of male rat exposed to chlorpyrifos RAD1 BAD PLEC ZAP70 APP RHO POR LAT PMC6292568__F2 Candida–streptococcal interactions in biofilm-associated oral diseases PMC11581872__F8 Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway CASP3 METTL14 METTL3 BCL2 MCL1 BAX PMC11676253__F1 Anti-Müllerian Hormone (AMH), signaling pathway in granulosa cells AMH AMHR2 FSHR PMC8654699__F6 Targeting SOS1 overcomes imatinib resistance with BCR-ABL independence through uptake transporter SLC22A4 in CML RAF1 SLC22A4 SOS1 PMC7237910__F3 Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2 ACE2 TMPRSS2 HEL-S-69p PMC6671871__F1 Lignin biosynthetic pathway CAD JCAD PMC4550414__F5 Network Topologies Decoding Cervical Cancer VEGFA CCND1 CDK4 MTOR PMC5923480__F2 Feline restriction factors and FIV counteraction mechanisms CXCR4 SERINC3 PMC8348676__F2 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis EIF2A BAX PMC8348676__F1 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis TLR4 ZC3H4 ATL3 MYD88 MTOR PMC2173691__F7 Mechanisms of E-cadherin regulation in sparse and dense cultures of colon cancer cells ERBB2 CAD PMC7338763__F1 What Matters for C4 Transporters: Evolutionary Changes of Phosphoenolpyruvate Transporter for C4 Photosynthesis CS GC MAL PMC8784274__F3 Transcriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma BIRC5 PPP2R2C GSK3B MYC SNAI2 BMPR2 WNT4 BMP5 PARD3 PRKCI BMP6 AREG APC FZD4 WNT10B FZD5 RASSF1 APC2 LAT CRB1 HEL2 AMOT PARD6G PARD6B WNT7A TEAD4 WNT9A CCND3 FZD1 MOBKL1A LATS2 NKD2 TEAD2 NKD1 BMP4 AXIN2 WWC1 SOX2 BMP2 AJUBA SCRIB WWTR1 ID1 PS1TP5BP1 LEF1 WNT3A BBC3 WNT2B WNT5B FRMD6 CRB2 FZD8 PMC7005212__F4 Compound-potential targets-disease network (Blue diamond represents compound target; red circle represents pathway; purple hexagon represents disease) PTGS2 RELA MAOA TNF ACD PMC8278527__F7 SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/Beta-catenin signaling APC GSK3B LRP5 LRP6 SFRP5 PMC5388917__F5 Regulation of Akt signaling pathways after (A) vehicle, and (B) melatonin treatments following ischemic-stroke BAD GSK3B GSK3A PTEN MTOR PMC9218606__F4 Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress KEAP1 GCLC HEL-S-44 NQO1 PMC9506554__F1 Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis HEL-S-61p SHMT1 MTHFD1 PEMT PMC3497272__F2 ErbB signaling and inhibition in tumour cell BAD ERBB2 GAB2 ERBB3 GRB2 BCL2 STAT3 BAX PMC5769965__F10 Cocaine and HIV-1 Tat Disrupt Cholesterol Homeostasis in Astrocytes: Implications for HIV-Associated Neurocognitive Disorders in Cocaine User Patients LDLR ABCA1 APOE PMC2732569__F2 The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics PINK1 AFM FIS1 OPA1 PMC2097959__F2 INTEGRATING RADIOTHERAPY WITH EGFR ANTAGONISTS AND OTHER MOLECULAR THERAPEUTICS FOR THE TREATMENT OF HEAD AND NECK CANCER COX2 EGFR GRB2 MTOR PMC5143322__F1 AHR signaling pathway PRKCA AHR RELA PTEN JUN PMC5768915__F1 HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway SOX2 LEPR FGFR2 SOX9 STAT3 PMC4113076__F7 Comprehensive and High Resolution Genome-wide Response of p53 to Stress ABCD3 PLK3 FTL XPC DDB2 GATC MED21 MTBP RARA RRM2B SDC4 OGT SDF4 KDM5C MDM2 RBM14 UTP3 SESN2 PCNA TRAF4 RAD51C PMC3932967__F2 Role of Notch signaling in the mammalian heart BMP10 MMP2 BMP2 TBX2 NRG1 PMC4095017__F2 Signaling and cross talk of the parathyroid hormone and Wnt signaling pathways in the late osteoblast (osteocyte) WNT3A F2 LRP5 LRP6 PTH DKK1 AXIN2 PMC11663867__F4 Cerebrotendinous xanthomatosis: a literature review and case study CYP27A1 CYP7A1 HSD3B7 PMC9142813__F1 Cellular and molecular basis of thyroid autoimmunity TH TSHR TPO TG PMC4204733__F3 Schematic diagrams of Wingless and Arm structure, and pathway relationships APC TEF BCL9 PMC8691188__F1 Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock CRY1 RORC CRY2 PER2 SIK1 PER1 PMC4518444__F6 Checkpoint clamp and clamp loader in crossover formation DMC1 RAD51 ATR PMC3666388__F5 Adult haemangioblast genetic regulatory network FLI1 ELK3 FLT1 FLT4 ETV6 ETV2 VEGFA EGFL7 SOX7 GATA2 PMC3515549__F7 Screening the Budding Yeast Genome Reveals Unique Factors Affecting K2 Toxin Susceptibility ALG8 VPS41 PMC3250521__F4 Inhibition of isoprenoid biosynthetic pathway by ATST [modified from Holstein et al RAP1A ARHA IPP RHOB PMC4007119__F6 ZZ primary bronchial epithelial cells show an enhanced inflammatory response dependent of the ERK/EGFR/ADAM17 pathway AREG EGFR TGFA ADAM17 PMC7952751__F4 Interplay between autophagy and apoptosis, and the regulation of autophagy and apoptosis by foot-and-mouth disease virus (FMDV) infection TRADD ATF4 EIF2A ATG14 PMC9505762__F1 Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease NLRP3 BCL2 DDT IL1B PMC7952751__F3 Schematic representation showing the interaction between foot-and-mouth disease virus (FMDV) viral proteins and host proteins in the innate immune system TBK1 TANK STAT2 IRF7 IRF9 TRAF3 IRF3 MX1 OAS1 TLR7 TYK2 ESD MAVS STAT3 SEC62 PMC7974548__F3 Mechanisms of cardiotoxicityAbnormalities in action potential duration or conduction velocity are associated with a direct block of ionic currents or inhibition of their trafficking from nucleus to cell membrane INA EGFR TNF PMC4868481__F7 Both the EMP (red) and the OPP (blue) pathways share intermediates with the Calvin–Benson cycle (circled in red), but not the ED (green) pathway TNLG7C HEL107 RPE HEL-S-162eP PMC3914444__F2 Scheme of PI3K/PTEN/AKT signaling network activated by heterodimerization of HER2/HER3 receptors induced by heregulin (HRG) and inhibited by pertuzumab, 2C4 HRG PTEN PMC8558833__F9 Anatase and Rutile TiO2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway IGF1R CTSK IGF1 NPS PMC329503__F9 The roles of Ras and Mob2 in S MOB2 RHO ACE2 PAG1 PMC6460507__F5 Notch and APP signalling pathways APP ADAM10 ADAM17 PMC4362832__F2 Standard pathway by which microRNAs are processed and loaded onto RISC to regulate gene expression DGCR8 DROSHA TF PMC4362832__F1 Endocrine resistance in breast cancer cells FGFR1 EGFR PMC8700759__F5 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance APC CD40 CD80 IFNG PMC2814179__F1 Therapeutic targeting of NOTCH1 signaling in T-ALL MAML1 NOTCH1 ADAM10 PMC4300045__F3 Gene ontology (GO) analysis using the DAVID software FES MYC PTEN RFWD2 TSC2 CASP3 PERP ATM CDK2 MDM2 CASP9 ATR BAX PMC8700759__F6 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance ROCK1 APAF1 MCL1 TNF DIABLO HTRA2 CASP4 GAS2 BAX PMC9263262__F1 MicroRNA/lncRNA Intertwined With the Wnt/Beta-Catenin Axis in Regulating the Pathogenesis of Triple-Negative Breast Cancer APC GSK3B LRP5 CCND1 LRP6 PMC4216940__F2 Majority of mitochondrial proteins/enzymes undergo reversible lysine acetylation CS UQCRB FH ACADVL ECHS1 HEL-S-5 PMC9520263__F3 Tumor resistance to immune checkpoint blockade and combination strategies to overcome resistance TLR8 TLR7 TLR4 TLR3 STAT3 PMC5989870__F1 Schematic diagram MMP7 APC GSK3B CCND1 OSR1 SOX9 PMC6449344__F1 CpgA is pivotal in prevention of 4PE-mediated metabolic gridlock NAGA HEL107 RPE HPR PMC6049507__F7 MiRNA and host targets are involved in common pathways MAP2K1 CDKN1B NFYC RAC1 CCND2 PMC7578260__F2 TRIM-mediated regulation of the TLR signaling pathway PIN1 IRAK1 IRAK2 TRIM21 TRAF3 TRAF6 IRAK4 MYD88 TLR4 MAL IRF7 TRIM8 IRF3 TRIM6 TRIM62 TRIM29 TLR3 TRIM23 TRIM40 TRIM13 TRIM9 TRIM38 TRIM56 TRIM28 TRIM27 TAB3 PMC8101438__F2 MTOR signaling pathway and its role in metabolic programs and differentiation of T-cell subsets BAD SOCS3 TFEB STAT4 CCR7 SMAD4 CAD SOCS5 PMC3675586__F1 Sugar nucleotide biosynthetic pathways identified in the genome of P GAL MPG PMC4324580__F5 Proposed mechanism of action of glycyrrhetinic acid (GA)-induced G1-phase arrest in non-small cell lung cancer (NSCLC) cells SUV39H1 CDK2 EIF2A DHFR CDK4 PCNA CDK6 PMC8997602__F1 Impact of Lipid Metabolism on Antitumor Immune Response STAT1 SLC27A2 IL8RB STAT3 PMC6341304__F1 Mitochondrial dysfunction and diabetic retinopathy POLG TFAM PMC7704563__F8 Schematic overview of the distinct roles of p38A depending on the disease stages during NAFLD progression CASP3 CXCL1 BCL2 NR1C1 PMC8097353__F1 Deubiquitinating enzyme USP42 stabilizes RNF43/ZNRF3 at the plasma membrane ZNRF3 RNF43 GPR49 USP42 LGR6 PMC2752535__F4 Common features of host-Flaviviridae interactions CYBA CSNK2A1 FLT4 SMAD2 DNAJB1 KCNK3 USP11 STIM2 TCOF1 HEL-S-76p MYO3A GSC YAP1 TNPO2 NCOA6 PRPF40A TRIM62 SMURF2 MAP3K14 CDH10 TBK1 CHUK TRRAP PPP2R1A RIPK2 HSF1 YEATS4 CITED2 TEAD3 ELAVL1 ZNF148 MT2A UBE2I TFAP2A HEL161 AP3S2 ZNF467 NUAK1 SKIL SMAD6 RAC1 SMURF1 DUSP11 RBPMS FOXA2 ADAMTS4 CISH BCAT1 MLXIPL ZAP70 WDR37 RAF1 TBL3 BCAP31 STAT3 PMC7945298__F9 NcRNAs involved the PI3K-Akt signaling pathway TSC2 TSC1 CDKN1A VEGFA EIF4E MTOR COL1A1 COL5A2 RPTOR RHEB MLST8 PMC6049507__F6 MiRNA targets in cancer pathways CREBBP MDM2 PMC7945298__F8 Subnetwork of PVT1 and HOTAIR STK17B CHAF1A NRIP3 RAP2C RB1 HIF1A FJX1 SOX4 MMP2 RRM2 F3 CCND1 ZMAT3 KIAA0513 CTSA ANKH DIPLA1 CAPN15 PTGFRN GNS SLC22A23 HMGB3 LIMK1 CERCAM MIDN SKIL VEGFA CEP55 JARID2 TRIM29 MPDU1 CDKN1A NUFIP2 TBC1D2 TNFRSF21 PLXNA1 KPNA2 TFAP2C ABCA1 DUSP2 PTP4A1 GDF11 FRMD6 PMC3674463__F1 EGFR pathway and downstream signaling pathways, including KRAS BRAF EGFR PTEN PMC3626681__F1 Molecular and biochemical studies in hyperlysinemia patients ALDH7A1 PIPOX AADAT AASS ECHS1 GCDH PMC8290102__F1 Streptococcus pneumoniae, S. pyogenes and S. agalactiae membrane phospholipid remodelling in response to human serum PC PGP SPN C1S PMC6923788__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)-AKT- mammalian target of rapamycin (mTOR) pathway TSC2 FGFR1 PMC11510507__F5 Signaling pathway diagram of phagosome (the images are sourced from the DAVID database 2024 CD14 TLR4 ST7 MPO MARCO TUBB VAMP3 STX18 HEL-S-99n RILP CD36 PMC6429784__F4 Schematic diagram for anti-ethanol caused damage in K ERG PGC PMC4278533__F4 Gene set variation analysis of the antigen processing and presentation pathway (APP) and the natural killer (NK) cell gene set CMKLR1 MHC2TA SET CLIC3 CX3CR1 PDZD4 GNLY CHST12 HEL-S-99n NCAM1 TAPBP IFNG CANX PRF1 ASCL2 IL2RB PMC7913835__F3 Protein–protein interaction network between gene products with high-impact variants contained in the top enriched pathways and those presenting differentially methylated sites in CLZ-treated patients HEL-S-7a PLCG1 LRP8 KCNMA1 RYR2 PRKCA KCNN2 SLC12A5 KCNJ6 DLGAP2 NR1A2 ABCC8 KCNN3 ITGB3 MED24 RXRG PRKG1 TBC1D4 KCNJ3 GABRR3 RXRA GABRA4 CACNA1I PCLO GABRG3 APOB PRKCB GRIA4 RYR3 GNAS GABRA6 AKT3 ADCY9 PMC12021615__F4 Other E3s and DUBs in NAFLD USP15 ACSS3 HSF1 FOXO1 NLRP3 ACAT1 TRIM56 PDHA1 MDM2 USP36 ACLY SKP2 FASN PMC12021615__F3 E3s and DUBs in NAFLD-related ERS, mitochondrial malfunction, and lipid autophagy HMGB1 HNF4A USP14 RNF186 EIF2A TRIB3 TXNIP TG CYP2E1 FASN PMC3855612__F4 Human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone TSC2 RICTOR TSC1 PTEN MTOR DEPTOR IRS1 RHEB PMC12021615__F2 E3s and DUBs in SIRT, TGFB, JAK, TLR4 and STING signaling pathway in NAFLD CARM1 TLR4 TRIM2 RNF13 SMAD4 ARID2 USP22 SIRT1 PMC12021615__F1 E3s and DUBs in TAK1, ASK1 and mTOR signaling pathway in NAFLD USP4 TRAF3 MAP3K7 TRAF6 MUL1 MAP3K5 MTOR DEPTOR USP18 TSC2 NLRP3 RICTOR TSC1 CYLD RHBDF2 DDX5 PMC5244594__F12 Working model of how the glucose dual-affinity transport system functions in glucose transport, signaling, and CCR CIRSR PMC5324334__F7 TSPC induces cell cycle G1 arrest probably mediated by CDKN1A and CDKN1B CKIs in a TP53-independent manner, while CDDP induces S and G2/M arrest via TP53/CDKN1A pathway in SK-MEL-5, and preventing dephosphorylation of CDK1 in both cell lines CDKN1A CDK2 CDC2 CCNE2 PMC7309952__F6 Regulatory network of the BCL2 family in gynaecologic and breast cancer BIK MYC PIK3CA BCL2L1 POR BAX PMC8622331__F4 Bacterial Ghosts-Based Vaccine and Drug Delivery Systems CD14 TLR5 TLR4 NLRC4 LBP LPP TLR1 TNF TIRAP PMC7343851__F7 SSP regulation of PI3K/Akt signaling pathway RICTOR RHEB ELL PMC4823950__F1 NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells CASP3 NGF CASP9 MCL1 FADD PMC8747764__F7 TPMT mRNA Expression: A Novel Prognostic Biomarker for Patients with Colon Cancer by Bioinformatics Analysis IGF1R GMDS FLNA ACTN1 TLN1 FPGT COX7A2 HEL-S-32 HEL-S-26 NANS NDUFS1 FH HEL20 UQCR10 SUCLG2 DLAT SDHD HK2 ME1 PAPSS2 ME2 PGM3 NDUFV2 MCEE NDUFA6 CYB5R4 NDUFAB1 ECHDC1 CALML4 NDUFS3 MLX GFPT1 CASP3 HSPG2 THBS2 PSEN1 THBS3 ITGA6 MYL12B GNPNAT1 NDUFC1 ETHE1 LAMC1 COMP VEGFB PMC6323238__F1 Regulatory system of ERK1/2 signaling DUSP4 DUSP5 FOS DUSP9 KSR1 EGFR MYC SHE DUSP2 DUSP7 KSR2 PMC8322647__F1 Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era NPS RAC1 ACE2 PMC4498564__F1 Heme biosynthetic pathway FECH AIP UROS CPO PMC4649622__F4 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice RARA IRF9 PIAS1 TYK2 JAK1 IFI35 IRF-1 PSMB8 SOCS1 MX1 BAX PMC12248764__F5 Fatty acid synthesis pathway in L HES2 HEL-S-5 PMC4649622__F5 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice TBK1 NAIP LIMK1 TRADD LMNA DIABLO HTRA2 GAS2 ZC3HAV1 BIRC2 SPTAN1 TRAF2 FADD CYCS ARHGDIB ACIN1 PMC4343025__F1 Genome organization and biogenesis of microRNAs (miRNAs) AGO1 AGO2 DGCR8 AGO4 DROSHA RAN PMC5000672__F6 Proposed signal pathway activated by HMDB in HeLa cervical cancer cells CDK2 CDK4 MTOR CDK6 PMC8997602__F4 Impact of Lipid Metabolism on Antitumor Immune Response COX2 LAG3 PMC7500051__F5 Opposite immune effects of M1-like and M2-like TAMs in the tumor microenvironment IL10 TH CCL20 CCL5 CCL22 ARG1 CEBPB IFNG FOXP3 PMC10243463__F1 BMP4 signaling in trophoblast emergence from pluripotency BMPR2 ACVR2B ACVR2A BMPR1A ACVR1C TGFBR2 MAP3K7IP1 BMP4 PMC5702246__F6 The PTHLH/PTH1R-ATF2 negative-feedback loop ATF2 UNK PTHLH PMC3364790__F4 Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells HEL-S-78p EHF TAL2 TNLG7C CP PMC11046856__F4 Crosstalk between Wnt/Beta-catenin, Notch, and TGFB signaling pathways during wound healing VEGFA AXIN2 COL1A1 HES1 PMC9179857__F3 Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays SPARC STOM PTPRO PMC11046856__F2 Non-canonical Wnt signaling pathways ROR2 RAC1 JUN PMC11046856__F1 Canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC7017008__F2 Main molecular mechanisms underlying EMT activation EGF HGF TWIST1 SMAD2 RHO STAT3 PMC6476857__F12 Graphical abstract shows the protective mechanism of SFN against Ar-induced damage in the kidney tissue via PI3K/Akt-mediated Nrf2 signaling pathway KEAP1 SFN PMC6277854__F2 Major signaling pathways and therapeutic targets in CLL cells BAD ATF2 MMP9 MYC RHO BTK LEF1 BCR CXCR4 SYK MCL1 JUN BAX PMC8580341__F4 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors PIM1 KLF4 BCL2 TYK2 RAF1 STAT3 PMC8580341__F3 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors HOXB7 NPR3 MDM2 GRB2 SHE PTEN PMC8580341__F2 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors ZNRF3 NLK RNF43 APC CTCF GSK3B AXIN1 EZH2 PMC8529754__F2 An update on extra-oral bitter taste receptors PLCB2 CALHM3 CALHM1 TRPM5 PMC5777140__F5 Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer’s disease CD47 NPNT CD44 VWF CHAD CD36 PMC8580341__F6 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors TSC2 BAD TSC1 SOX2 MDM2 PTEN RHEB BAX PMC7559526__F8 Melanin synthesis pathway related genes in dorsal and ventral skin of LBM ducks POMC ASIP PMC7565286__F1 Summary diagram of transport, signaling and degradation of vitamin A metabolism and RA synthesis ALDH1A3 RBP4 HEL-S-53e DHRS3 ALDH1A2 PMC8580341__F5 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors SIRT1 BAX PMC9343736__F3 Endothelial cells in vascular calcification MGP BMP6 IL18 SOX2 RUNX2 BMP2 SMAD2 SMAD4 BMP7 BMP4 PMC7039698__F1 Topical cholesterol/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy PMVK MVD ACAT1 IDI2 FDPS MVK IDI1 HMGCS1 GGPS1 HMGCR ACAT2 PMC5951830__F7 Metabolism of bicarbonate and t6A37 formation in cytoplasm and mitochondria OSGEPL1 CA9 YRDC PMC5882218__F1 Models of the Hippo pathway in mammals LATS1 LATS2 PMC6037882__F4 Role of mucins in CSCs MUC1 MUC4 PMC5325457__F5 Ubc13: the Lys63 ubiquitin chain building machine RNF8 TRADD IRAK1 TRAF3 TRAF6 CD40 IRAK4 TRAF2 FADD TAB3 PMC11853667__F1 mTOR signaling pathway in cells TSC2 RICTOR ULK1 TSC1 WNT3A PTEN MTOR RHEB MLST8 PMC7013532__F1 Pathway associated with terpene synthesis in Camellia sinensis MVK IPP PMC9416350__F2 Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review CXCL10 CXCL9 CCL4 CD80 CXCL11 CCL3 PMC7048048__F2 Directionality of transketolase 2 (TKT2) impacts the in silico essentiality of two genes encoding EDD and EDA from the Entner–Doudoroff pathway TNLG7C RPE PMC7048048__F1 Core networks generated by the redGEM algorithm from iJN1411 genome-scale model ME2 CS PC NADK TNLG7C RPE MAL PMC7229984__F1 Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival DKFZp781B1423 EGFR PTEN NBPF14 DLL3 TLK2 KDM5A CCNE1 FRS2 SUFU PTCH1 GLI3 MDM2 SHH hCG_2014051 SMO CDK4 PSENEN AKT3 PMC9224267__F2 EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment EGFR STAT3 PMC6248540__F2 Pathway analysis infers molecular pathway of relapse ASAP1 CD44 RHO TG PMC2975936__F1 Classical pathway of complement activation by antibody HEL-S-62p C4B_2 C4A PMC8192181__F5 Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NFKB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways IL16 CXCL10 CCL5 TNF STAT3 CCL3 PMC8063837__F2 Models of signaling in Hedgehog pathway activation in cancer IL1A SMO IL1B PMC7401422__F3 Visualization of the cell cycle pathway from WikiPathways POLE2 POLE PCNA PMC6209826__F10 We observed that chlorogenic acid showed binding affinity to interact with ctDNA, VEGF and VEGF receptors PIK3CD FOXO3A FOS FGF2 MMP9 EGFR VEGFA MTOR FOXO1 MMP3 VEGFC IL18 MMP14 KDR TIMP1 MMP2 TIMP4 TIMP3 MDM2 PIK3CA JUN TGFB1 TGFBI PMC8063837__F1 Hedgehog signaling pathway and its possible inhibitions BOC SUFU GPR161 SMO PMC4621741__F1 Mutant SPOP promotes genomic rearrangements within chromosomes MAP3K7 SPOP PMC10302997__F1 Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention ULK1 PI3 ATG16L1 ATG12 ATG3 UVRAG ATG10 MTOR DKFZp686F0183 PMC5732091__F6 CHOLANGIOCYTE PRIMARY CILIUM IN HEALTH AND DISEASE APC GSK3B UNK ARHA PMC3924769__F6 DAF-12, a nuclear hormone receptor regulating development and lifespan CYP27A1 ADA HSD3B7 PMC3961794__F1 Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1 TLR4 IRF3 TYK2 MYD88 JAK1 STAT3 PMC3294814__F1 Proposed biosynthetic pathway of RQ (compound 1) TH COQ3 COQ2 COQ6 COQ5 COQ7 PMC4849794__F7 Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson’s Disease STAT1 E2F4 DES JUN TAF6 PMC6025799__F2 Roles of IGF2BP1 in promoting and suppressing tumor growth and invasion via regulating different mRNA targets, under the modulation of upstream non-coding RNAs IGF2BP1 MAPK4 RGS4 PTGS2 CD44 PTEN RAC1 MKI67 PS1TP5BP1 PMC3063194__F1 Elicitation of innate immune response in EBV infection TBK1 TLR7 TANK TLR9 IRF7 TRAF3 IRF3 IL6 MYD88 TLR3 PMC4694849__F4 PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines PIK3CD TSC1 PRKCB PIK3CA PTEN MTOR RHEB PMC10299455__F2 NOTCH signaling pathway, ligands, and inhibitors FYN RBPJ LYN MYC BLK HES1 PMC3127069__F1 The mTOR-signalling pathway from growth factor receptor through mTOR PTEN MTOR RHEB PMC8869290__F1 Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases EDEM1 EDEM2 EDEM3 UGGT1 PMC3281277__F1 Proteolytic processing of the BACE1 substrates APP and NRG1 BACE1 EGF ADAM10 NRG1 PMC5882331__F2 Therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer TIGAR SCO2 ATM MDM2 XPC ATR BAX PMC3063194__F2 Evasion of immune responses by individual EBV products IL10 CASP3 TLR7 IRF7 IRF9 IRF3 IRF4 FADD CXCL11 PMC6326993__F2 Schematic overview on a striatal medium spiny neuron synapse TH PDE10A ADCY5 GNAO1 GNAL PMC8259786__F4 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease MGP BMP2 SOX9 PMC8259786__F3 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease WNT4 BMP2 NOTCH1 HBEGF PMC8259786__F2 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease RBPJ CDKN1A DLL4 EFNB2 DLL3 PMC8869508__F3 Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches NLRP3 COX2 NLRC4 NLRX1 IL1B MAVS PMC3706396__F6 S100A8/A9 (Calprotectin) Negatively Regulates G2/M Cell Cycle Progression and Growth of Squamous Cell Carcinoma CDK2 S100A8 CCNB1 S100A9 PMC6587703__F2 Mechanistic interactions between VEGF-targeted anti-angiogenic therapy and checkpoint inhibitors in the systemic treatment of mRCC GRB2 VHL CCND1 PTEN GAL TGFA CDC42 PMC4865041__F7 Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database SET PACRG CCND1 BCL2 PARP1 BCL2L1 MCL1 BNIP3 CDKN2A PMC6336016__F2 Application of built-in adjuvants for epitope-based vaccines TLR5 TLR7 TLR4 TLR9 IRF3 MYD88 TLR1 TLR3 MAL PMC7568023__F2 Engineered nanomaterials as fighters against SARS-CoV-2: The way to control and treat pandemics C4B_2 NPS ACE2 PMC4159649__F6 Identified glycotransferases involved in O-glycosylation and associated biosynthetic pathway HEL-S-62p GCNT3 B3GNT6 B4GALNT2 FUT6 B3GNT3 GAL3ST2 FUT5 SIAT4C CHST5 FUT3 B4GALT4 GAL B3GALT5 PMC3697962__F2 Insulin-like signaling pathway PTEN INSR PMC8666273__F5 Runx3 regulates iron metabolism via modulation of BMP signalling BMP6 RUNX3 HAMP PMC8036928__F3 Antioxidant metabolism in circulating tumour cells (CTC) ME1 CPT1A MAL PMC9483553__F2 Prominent Role of miR-942 in Carcinogenesis of Tumors BAMBI SFRP4 BATF2 SOCS3 DLG2 SALL1 APC GSK3B ALX4 GAS1 MBL2 ZNF471 FOXA2 CUL4B RRM2B GDNF GFI1 PMC11797775__F2 The main cell signalling pathway mechanisms reportedly disrupted by hyperglycaemia-associated oxidative stress and AGEs in MSCs, osteoblasts and osteocytes, potentially contributing to impaired bone healing in T2DM patients RUNX2 APC MTOR PMC4664460__F3 Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain TSC2 TSC1 EIF4E PMC8656569__F1 miRNAs in the Regulation of Cancer Immune Response: Effect of miRNAs on Cancer Immunotherapy TRADD CYLD IRAK1 TRAF6 IRAK4 MYD88 TRAF2 FADD TIRAP PMC9327201__F4 Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment CSF3 GLS PMC3351343__F6 Working model for onset of emphysema in Fut8+/− mice upon exposure to CS FUT8 SMAD2 TF PMC3734825__F7 Upregulation of HSP70 and the phosphorylation of STAT1 induced by bortezomib (BTZ) decrease the cytotoxic activity against ovarian cancer cells STAT1 BAD HSF1 PMC5932138__F6A Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition HEL-S-62p C4B_2 CLK1 FH PMC8502867__F2 Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination PRIMPOL SSB RAD51 EME2 PRIM1 EEPD1 PMC8960495__F9 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice SETD4 AURKA RHOU CP PMC2475726__F10 F igure 10.— REV1 RAD52 PMC8960495__F7 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice DKK3 DIXDC1 RHOU CP PMC11016009__F4 B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention ULBP2 STAT3 PMC5913290__F1 Key elements in the DNA damage response (DDR) pathway ATM SSB ATR PMC4246027__F1 NEUROTROPHINS IN THE VENTRAL TEGMENTAL AREA: ROLE IN SOCIAL STRESS, MOOD DISORDERS AND DRUG ABUSE NGF GRB2 TRAF6 BDNF TRAF4 PMC8387624__F5 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis APOBEC3B CDK2 EZH2 STAT3 PMC8387624__F4 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis EGR1 P4HA2 MMP2 MMP9 ZHX2 ATF5 EZH2 SP1 VDAC3 MTOR FOXO1 STAT3 PMC8574196__F3 ApoE and AB interaction LDLR ABCA1 APOE PMC6518354__F1 Schematic drawing presents the detail signaling pathways of endometrial carcinogenesis EGF BAD APC SRC PTEN MTOR PMC7127985__F1 Molecular pathways involved in PKD, autophagy and apoptosis ULK1 BAD ATG12 PRR5 ATG3 MTOR BAX PMC8194326__F1 T follicular helper cells: linking cancer immunotherapy and immune-related adverse events CD40 CD80 PMC6130072__F2 Transcription factor interactions in endothelial cell functions TSC2 TSC1 ETV2 RHO FOXC2 FOXO1 RHEB PMC9338502__F3 Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation HES5 NUMB HES1 PMC7793262__F2 Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation IL10 STAT1 IFNG STAT3 PMC4963951__F2 The roles of monocytes and polarized macrophages in HTS formation CXCR4 NOS2 ARG1 STAT3 PMC2818240__F5 Oxidative stress and glutathione in TGF-Beta-mediated fibrogenesis SMAD2 SMAD4 SP1 PMC3414727__F2 AKT/mTOR signaling and crosstalk with glycolysis and mitochondrial oxidative phosphorylation TSC2 TSC1 HIF1A PMC9556184__F1 Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease PINK1 VDAC3 BAX PMC408363__F1 Complexity of the CD28/CD152–B7-1/B7-2 T-cell costimulatory pathway APC CTLA4 PMC3414727__F1 AKT/mTOR signaling pathway ULK1 BAD GSK3B PTEN EIF4E MTOR DEPTOR RHEB MLST8 TSC2 RICTOR TSC1 IGF1 SESN3 PMC8510628__F1 Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation ANXA1 SRC IL1B PMC2949778__F1 Folate metabolic pathway RFC1 MTR MTRR TYMS PMC5359927__F1 Main signaling pathways involved in vasculogenic mimicry COX2 MMP14 MMP2 NODAL ALK TWIST1 CRIPTO BNIP3 EPHA2 PMC6990917__F8 Mechanism of the protective effect of fenofibrate against diabetic nephropathy FGF21 FYN GSK3B NR1C1 NQO1 PMC3536591__F2 Ingenuity pathway analysis (IPA) top network that incorporates 9 genes identified as differentially methylated between methotrexate-naïve cases and controls by HM27 analysis IGF2BP1 TIAL1 COX1 MYC BDKRB1 EIF2AK2 S100A7 LAMA1 MYBL1 NPY LIN54 EIF2A HCRTR1 MPL TARBP2 CCNE2 PMC7758122__F4 Cross-talks between seven primary regulatory pathways of RDNI for inflammation IL16 PTGS2 RYR2 PMC7709275__F1 Role of the unfolded protein response (UPR) in cancer ATF4 EIF2A PMC5893845__F6 Schematic diagram on the transcriptomic profiles of metabolic pathway genes involved in the enhanced MCFA production of mutant cC14TE_B3 D PDC CIRSR GIP HEL-S-5 PMC7709275__F3 MiRNAs regulate tumor characteristics including apoptosis, invasion, EMT, and metastasis by regulating the UPR HMGB1 SNAI1 LAMP3 GDF15 ATF4 EIF2A JUN TUSC3 PMC8222490__F2 Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue NPNT ITGB6 ITGA7 ITGA4 COL1A1 ITGA2 DAG1 GP5 opn SV2C VWF ITGA1 FRAS1 RELN CD47 ITGB3 SDC1 ITGA2B CD44 FREM1 ITGB1 DMP1 TNC GP9 ITGB4 HMMR HSPG2 ITGB7 ITGA6 VTN IBSP CHAD ITGAV COMP GP1BB GP1BA GP6 CD36 AGRN PMC7709275__F5 LncRNAs regulate the tumor characteristics apoptosis (a), invasion and metastasis (b), and metabolism (c) by regulating the UPR HEL-S-84 ATF4 EIF2A EGLN2 PMC6735501__F1 Initiating events in autophagy ULK1 ATG16L1 ATG12 ATG3 SQSTM1 ATG101 ATG10 DKFZp686F0183 RB1CC1 PIK3R4 PMC3440368__F7 Disturbed Relaxin Signaling Pathway and Testicular Dysfunction in Mouse Offspring upon Maternal Exposure to Simazine MMP9 NOS2 PMC10538757__F2 STRING analysis of protein–protein interactions BAD USP2 ABAT NOTCH1 SYF2 REL RBM22 AQR ABCB1 PRPF19 STAT3 MAL PMC8355346__F1 Molecular mechanisms and signaling pathways of ferroptosis interact with AS GPX4 TLR4 HAMP SLC7A11 ATF3 SLC3A2 PMC5748821__F1 Nuclear factor-E2-related factor 2 (NRF2) pathway with a focus on skin barrier function and environmental stress protection ME1 EPGN GCLM KEAP1 SQSTM1 SLC7A11 GCLC RBX1 SLPI TXN DKFZp686F0183 NQO1 TP53BP1 HEL-S-26 COX2 CDKN1A BCL2 RAD51 OGG1 SRXN1 PMC5587385__F7 InterferonA Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for SLE VCAM1 IRS1 PMC6601327__F6 Proposed model of OLFM4‐induced STAT3 activation mediated by the LGR5‐Wnt signaling pathway in HCC APC OLFM4 GPR49 STAT3 PMC11120359__F1 Representation of the signaling pathway in the activation of CXCR4 (left) and ACKR3 (right) ACKR3 CXCR4 CXCL12 MTOR PMC7426575__F5 Schematic Model for Major Immune Escape-Initiating Domains and Immune Escape Points in Tumor-T Cell Interaction(A) Major immune escape points depicted in schematic model, highlighting tumor-T cell interaction at last stage of cancer-immunity cycle CXCR3 CXCL9 IFNG PMC5789323__F2 Simplified relationship between ROS-induced redox signaling and mitochondrial dynamics KEAP1 HIF1A OPA1 PMC7859329__F2 Thyroid hormones, Wnt pathway, and miRNAs crosstalk MED13 DKK4 PMC10218387__F3 Major pathways of carbon and energy metabolism in M382 MIA HEL-S-304 SMO TNLG7C HEL107 HEL-S-32 AGXT2 PMC3733085__F2 Simplified scheme of the pathways of complement activation HEL-S-62p CD46 FH CD55 C1S PMC2844310__F3 Relationship of NFKB to genes identified as “linearly” changing with age on the basis of cocitation analysis (Genomatix BibliosphereTM) is shown as a Bibliosphere image NPHS1 ECD NFKB1 DES RAMP2 PMC5966807__F4 A schematic showing the proposed signaling pathways in type II cells activated by neurochemicals at the carotid body sensory synapse H1-2 PANX1 PMC2680180__F1 Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? SIRT4 SIRT5 SIRT3 PMC9318003__F2 Will We Unlock the Benefit of Metformin for Patients with Lung Cancer? Lessons from Current Evidence and New Hypotheses TSC2 EGF TSC1 ERBB2 HIF1A MTOR SIRT1 RHEB PMC5693226__F1 Rationale for mTOR inhibitor + NOTCH inhibitor combination RIDA DLL4 PTEN MTOR HES1 PMC8168945__F1 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling DHCR7 EBP SC5D DHCR24 HSD17B7 CYP51A1 PMC5457688__F4 Précis of signaling pathways involved in glioma and inhibition by mTOR, AKT, PI3K and ERK inhibitors and genetic configuration of TSC1 and TSC2 TSC2 TSC1 PTEN EIF4E MTOR RHEB PMC8168945__F6 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling DHH IHH SHH PMC11307883__F3 Metabolic pathways of the microRNAs and their target genes PIG59 CSF3R GLS2 SKP1 IL6 RB1 CDKN2A GAD1 CDK6 CCNE1 ALDH5A1 CDKN2B MAX ABAT CDK2 HEL-S-8a CCND1 CDK4 CAD GLUD1 SKP2 PMC6562905__F2 Role for fibroblast-derived metabolites in tumor-stroma interactions PIG59 AEN HEL-S-281 PMC9585453__F4 Systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury APC GSK3B LRP5 LRP6 PMC9496700__F1 Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma RRBP1 CCNB1 EPHA7 TESC IRAK4 TUG1 EIF4E MTOR IFITM1 PMC6431727__F5 RANKL-RANK signaling pathway via Btk in osteoclast differentiationTec family kinases are activated by RANK and bind to scaffolding proteins (BLNK or SLP76) activated by ITAM signaling, thereby forming a complex that cooperates to activate PLCG2 BTK NFATC1 BASH TEC SYK PLCG2 PMC2440410__F3 Regulation of post-cushion valve maturation to thin fibrous leaflets also includes EGF receptor signalling in addition to differential signalling of the pathways in c EGF BMP2 SMAD2 EGFR ERBB3 SMAD6 SMAD4 HBEGF BMP4 ERBB4 ERBB2 SMAD1 DKFZp781O1323 PMC10671144__F7 Network analysis of oxaliplatin revealed that oxaliplatin as a master regulator was predicted to be inhibited and the SPINK1 pancreatic cancer pathway was inactivated in ischemic cardiomyopathy PRSS1 PRSS2 CLPS SQSTM1 SPINK1 TGFBR1 F2RL1 TGFBR2 TGFB1 CP TMPRSS15 RGS11 PMC10671144__F1 Carboplatin molecular network in cancer PDX1 RUNX2 SMAD2 CDKN1B TP63 BRCA1 tal-1 TBX21 EP300 CDKN1A NFKB1 RELA EZH2 JUN PMC10671144__F3 Upstream regulator analysis of cisplatin revealed the upregulation in FAS, PRKCA, and CDKN1A, and involvement of tumor microenvironment pathway (lung adenocarcinoma (LUAD) [lung] cisplatin 9800) PPM1D XPC ATF3 GADD45A RPS27 BTG2 CP PMC4889031__F1 Deletion of ERA in uterine epithelial cells leads to infertility, however, this receptor loss does not prevent estrogen induced epithelial cell proliferation () MUC1 EGF IGF1R IGF1 BMP2 LIF EGFR HEL110 STAT3 PMC4821530__F5 GUIdock: Using Docker Containers with a Common Graphics User Interface to Address the Reproducibility of Research BRAF BCL2L1 WWP1 XBP1 CRKL SF3A1 CCNE1 NF1 CDKN2B ZRSR2 KDM5C PIK3CA CCND1 SPOP MCL1 EZH2 PMC8535854__F1 Metabolic reprogramming orchestrates primary tumor cell invasion and supports PMN priming via exosomes ATG3 PMC5900707__F1 Schematic diagram of RIPK1 domains, interacting proteins, post-translational modifications, and the catalytic enzymes that read or write these modifications RIPK1 TRADD CYLD RIPK3 PELI1 OPTN TRAF2 PMC8535854__F2 Metabolic changes allow cancer cells to survive in circulation and promote colonization of distant organs HEL-S-26 PRODH SRC PMC6096407__F5 Several lncRNAs work at the post-transcriptional level as competing endogenous RNAs for microRNAs, titrating microRNA effector complexes away from their mRNA targets (e.g SIRT1 PMC6096407__F4 LncRNAs can regulate gene expression by participating in chromatin looping (e.g ASCL2 TCF4 PMC6096407__F1 Several lncRNAs interact with transcription factors recruiting them to their target genes (e.g TCF4 PMC8843871__F3 Paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine ANXA2 NOP2 EIF4B CUL4A PPP2R2A PMC6627906__F1 Signaling pathways and receptors involved in uveal melanoma (UM) and cutaneous melanoma (CM) GNA11 IGF1R HGF BRAF IGF1 CXCR4 PTEN CXCL12 MTOR PMC6096407__F3 LncRNAs activate (e.g DKK1 HDAC1 PHB2 PMC6096407__F2 Several lncRNAs bind to specific combinations of regulatory proteins, potentially acting as scaffold elements within ribonucleoprotein complexes, stabilizing their targets (e.g GSK3B AXIN2 CDK6 TCF4 PMC2746247__F1 Pathway Engineered Enzymatic de novo Purine Nucleotide Synthesis PURB NDP PMC5900707__F2 Activation of TNFR1 may promote multiple alternative signaling pathways, including the activation of NFKB, RIPK1-independent apoptosis (RIA), RDA, and necroptosis RIPK1 TRADD TRAF5 CYLD RIPK3 PELI1 TNF TRAF2 FADD TAB3 PMC10519225__F5 Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles PROC B2M PMC6862675__F4 IPA® analysis of signalling pathways of the genes differentially expressed upon lysozyme treatment UBC FYN KHDRBS1 PLAUR IL36A RGS1 HEL113 GDF1 ADM IFI6 LRIF1 PMC6518697__F6 Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease SOCS3 LGALS9 LFNG EFNA2 MMP7 NPR3 SPINK1 EMCN EZH2 NTRK2 AIP PDGFRA VEGFA FHOD3 TLL1 BCAN DNAH2 ANGPT1 TNC DENND2A HEY2 SCUBE3 KLF2 SAA2 DNA2 CP STAT3 PMC7026191__F3 CEACAM3 signaling connections CARD9 CEACAM3 BCL10 SRC PMC11302569__F3 Four key mechanisms of gut microbiome associated with the occurrence and progression of colorectal cancer a HGF CCR6 APP PMC6252326__F1 Schematic representation of the tryptophan metabolism pathway HEL-S-90n KYNU KMO PMC4935337__F6 Proposed model for the action of KP-A021 on the RANK signaling pathways in osteoclast differentiation, bone resorption, and cytoskeletal rearrangement NFATC1 SRC TRAF6 MAP3K7IP1 TRAF2 PMC2606944__F9 Role of Small GTPases and AvB5 Integrin in Pseudomonas aeruginosa–Induced Increase in Lung Endothelial Permeability ARHA PMC7876385__F3 Major mechanisms of drug resistance in BCSCs APC PTCH1 GSK3B LRP6 PTEN ABCG2 MTOR STAT3 PMC7876385__F4 Novel strategies of drug resistance reversal in BCSCs DHH RICTOR SUFU SHH BCL2 SMO PTEN ABCG2 FADD PMC5482964__F3 Signal transduction by BG TBK1 TLR4 TRAF3 TRAF6 IRF3 HEL-S-92n IRAK4 TIRAP PMC11434829__F1 Simplified overview of the omega-6 and omega-3 PUFAs metabolism, focusing on the AA metabolic pathway components with relevance in CF COX2 LTC4S PMC6940896__F13 A sketch map of immunoregulatory induced by LTAa TRAF6 MYD88 IL1B PMC9051099__F8 MyD88 signaling in HSCs in fibrosis model STAT1 CXCR3 CXCL10 MYD88 JAK1 NOS2 TNF PMC8899859__F10 Obstructive Sleep Apnea Affects Lacrimal Gland Function HIF1A NR1C1 CD36 PMC9208186__F7 Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis RBPJ IL1B ARID5A STAT3 PMC4490005__F3 Vav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 PLCG1 FOS CSK VAV1 PTEN ITK FYN BCL10 LCK GRB2 CSA2 REL JUN PMC7016661__F2 TNF-TNFR2 signaling pathway RIPK1 TNF TRAF2 PMC7300552__F1 ACE2 function and its regulation in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection ATR ACE2 TMPRSS2 PMC4306584__F7 Extracellular Hsp90 mediates an NFKB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment RELA STAT3 PMC11009184__F7 Translatability of mouse muscle-aging for humans: the role of sex PIK3C2B MTOR IRS1 AKT3 PMC11843152__F7 NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis CCNB1 CDC2 MTOR PMC3309942__F1 Interaction motifs and domains of RANKL signal intermediaries PTMS TRAF6 COIL PMC10216531__F1 The fundamental parts of TLR4 signaling TBK1 CD14 TLR4 TRAF3 LBP RIPK3 TRAF6 IRF3 MYD88 TIRAP PMC5842063__F1 METABOLIC SWITCHING AND CELL FATE DECISIONS: IMPLICATIONS FOR PLURIPOTENCY, REPROGRAMMING AND DEVELOPMENT LIF MSC MYC KLF4 HIF1A SIRT1 PMC4291019__F6 ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock IRF3 MYD88 ARF6 TIRAP PMC3309942__F2 p62 in osteoclast signaling and protein trafficking CYLD TRAF6 PMC4053506__F8 D-PDMP inhibits ox-LDL induced LCS activity and atherosclerosis development LPL SREBF2 ABCA1 HMGCR CYP7A1 CD36 PMC8208232__F1 Cross-talk between lipid homeostasis and endoplasmic reticulum stress in neurodegeneration: insights for HIV-1 associated neurocognitive disorders (HAND) PC EIF2A TG PMC11546859__F12 Analysis of the pentose phosphate metabolic pathway HEL-S-41 HEL-S-304 PMC11546859__F11 Analysis of the glycolysis/gluconeogenesis metabolic pathway PDC DLD DLAT HEL-S-162eP PMC3421730__F6 The antiviral IFN response in infected THP-1 cells TBK1 PIN1 TANK IFNA4 TRAF3 TRAF6 IRF3 IFNG ISG15 RIPK1 UNK JUN FADD MAVS PMC9196867__F1 Current Concepts on Pathogenic Mechanisms and Histopathology in Cutaneous Lupus Erythematosus TBK1 CXCR3 CGAS PDC MYD88 TNF PMC4349428__F2 The relationship between genotypes and phenotypes of the nucleotide excision repair pathway and risk of SCCHN XPC ERCC1 XPA PMC8304822__F1 Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer WIZ PTEN PMC9463785__F1 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition MYC CCL2 RB1 POR HIF1A B2M ABCC2 ABCB1 GHSR SST FOS VEGFA TNF GAST HEL-S-22 CCKBR HLA-A GNA11 LEP IGF1 HEL-75 BCL2 BDNF PCNA ALDH2 CD36 HLA-G MPO EGFR DPP4 INS ADAM17 INSR UBC F3 ELANE CYP1A1 CDC2 JUN FASN BAX GPC3 PTGS2 NFE2L2 NTS IL6 CFTR CASP3 CREBBP EP300 CYP3A4 RELA TYMS CYCS STAT3 PMC3279601__F1 The Immunologic Revolution: Photoimmunology CD207 CD1D DDC CXCR4 IL33 PMC9463785__F3 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition MYC CCL2 IFNG MMP3 MMP2 SRC MAPK1 NOS2 ABCC2 ABCB1 GHSR SST CTSO FOS YAP1 GSTM1 VEGFA TNF GAST CCKBR GNA11 FER LEP IGF1 CDKN1A CDK2 CXCR4 NR1C2 HEL-75 BCL2 SIRT1 ALDH2 CD36 CXCL1 HLA-G MPO NR3A2 EGFR TGFBR2 PTEN MTOR TOP2A COL1A1 INSR IL18 RPS27A F3 IL2 CYP1A1 CDC2 JUN FASN BAX IL10 EGR1 GPC3 PIR NTS PARP1 ARHA RAC1 HEL-S-130P CYP2E1 CFTR SPR CREBBP EP300 CYP3A4 NFKB1 RELA PIK3CA TYMS PPARG PMC9491525__F6 Putative BvrR/BvrS TCS regulon in B. abortus upon entry into the host cell PURA HEL107 PSD HEL-S-162eP PMC6913305__F4 Regulatory network of transcription factors in OA includes dark green quadrilateral module and light green rectangle module MYB ATF2 ETV4 CREB1 RB1 HIF1A BTF3 ING4 STAT1 NR1i1 POU1F1 SREBF2 EZH2 SP1 RUNX3 HOXA9 RFX5 FOXF2 STAT2 USF2 CEBPA BRCA1 EGR2 KLF4 YY1 KLF2 NUPR1 PGR ESRRA XBP1 RFXAP MEF2D ATM ATF4 NKX2-5 KDM4B ETS2 HOXA10 RFXANK JUN EGR1 HMGA1 BCAR2 EP300 SPI1 NFKB1 RELA HOXA1 REL STAT3 PMC5002303__F2 Insulin signaling pathway TSC2 BAD PDK2 GRB2 INS MTOR FOXO1 RHEB INSR PMC3004338__F4 Ingenuity Pathway Analysis (IPA) of differentially expressed genes between 24 DSS and 56 uncomplicated dengue patients SELPLG HEL57 INCA1 TFPI RNASE3 TEF SERPINA3 STAR RBM4 PMC7728626__F3 C-Jun N‑terminal kinase (JNK) activation in obesity-induced diet: FGF21 SOCS3 NCOR1 IL6 TNF NR1C1 PMC8763135__F3 Immune-targeted therapeutics and mechanisms of action investigated in major depressive disorder NLRP3 COX2 IL18 COX1 KMO IL6R PMC4945937__F8 Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway TIGAR HEL-S-30 MDM2 HEL-S-133P BAX GLS PMC10526115__F3 Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented? NGF ATF4 GSK3B IL17A ISCU BDNF IRS1 AKT3 PMC5659989__F1 Overview of the role of adiponectin in the crosstalk between AT and the cardiovascular system for the regulation of cardiovascular redox state RAC1 PMC2742468__F1 Metabolic cooperativity between oocytes and cumulus cells, and the role of oocyte-derived paracrine factors in promoting metabolism in cumulus cells SQLE HEL-S-49 PMVK FDPS EBP SLC38A3 BMP15 MVK ENO1 HEL-S-87p PFKP HEL-S-133P PMC5529882__F3 Detailed molecular network of pathways of the cell cycle (Kyoto Encyclopedia of Genes and Genomes ID, has04110) CDC6 CDK2 SMC3 MYC SMAD4 RAD21 CDK7 PCNA SKP2 PMC10813163__F1 Schematic illustration of leptin-induced signaling pathways MTOR STAT3 PMC8613079__F1 Complement in metabolic disease: metaflammation and a two-edged sword HEL-S-62p PMC11813047__F1 STAT3 signaling pathway SRC IL6 STAT3 PMC3749067__F1 Wnt/Beta-catenin signaling pathway APC GSK3B PMC5621755__F2 AhRR with the canonical and non-canonical AhR pathways AHRR AHR RELB CCL1 PMC5621755__F1 Schematic illustration of the repression of the canonical AhR signaling pathway by AhRR AHRR AHR PMC10033548__F7 SFRP1 induces a stem cell phenotype in prostate cancer cells APC SFRP1 PMC7522570__F9 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) tricarboxylic acid cycle (ko00020) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) CS PC PCK1 FH PDHA1 DLD OGDH ACLY SUCLG2 DLAT HEL-S-32 SDHA PMC7522570__F8 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) glycolysis and gluconeogenesis (ko00010) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) PCK1 FBP1 ENO1 GCK PGAM4 DLD ACSS2 PFKL HEL-S-87p ADH1A HEL-S-68p HEL-S-162eP HEL-S-49 HEL-S-165mP MINPP1 PDHA1 PKLR ADPGK DLAT PMC4753283__F1 The kynurenine pathway of tryptophan catabolism and markers of interferon-Gamma-mediated immune activation HEL-S-90n KYNU KMO PMC7651821__F2 Tumor progression by E3 ligases and DUBs BRAF DKFZp781B1423 APC TRAF6 SKP1 PTEN MTOR RBX1 FBXW7 FOXO1 CDC20 USP14 CYLD COPS5 ERBB2 MDM2 CCND1 TRAF2 SKP2 FASN PMC3894167__F1 Is Non-Homologous End-Joining Really an Inherently Error-Prone Process? ATM PARP1 XRCC3 MRE11A PMC2930641__F2 MAPK Signaling Pathway CD14 EGF NGF MOS FLNA EGFR TRAF6 CDC25B MAP3K7IP1 NLK NF1 PAK1 MAX GRB2 JUND ECSIT RAF1 BDNF TRAF2 MEF2C PMC7185488__F3 Hypothesized Human Endogenous Retrovirus (HERV)-Mediated Activation Cascades Leading to the Pathogenesis of Multiple Sclerosis (MS) TLR4 SAG APC HEL-S-92n PMC1868540__F1 Canonical Wnt Signaling Pathway APC LRP5 PMC3742224__F3 Structure of human cine-N-methyltransferase (GNMT) gene in connection with scheme of sarcosine genesis in biochemical pathway HEL-S-182mP PMC7107779__F7 Diagram revealing the impact of p62 on the initiation and development of tumors in prostate tissues through the Keap1/Nrf2/ARE pathway GCLM KEAP1 NQO1 PMC1551980__F4 Ubiquitin Signaling in the NFKB Pathway BCL10 TRADD TRAF6 MYD88 TRAF2 NOD2 PMC1551980__F3 Ubiquitin Signaling in the NFKB Pathway CYLD TRAF6 MYD88 PMC2919275__F2 PD-1 Pathway in Tolerance and Autoimmunity PTEN MTOR PMC2919275__F3 PD-1 Pathway in Tolerance and Autoimmunity APC FOXP3 PMC4402192__F2 Role of antagonists in Wnt signaling pathway APC SOST GSK3B LRP5 LRP6 RHO PMC4402192__F1 Canonical and noncanonical Wnt signaling pathways APC LRP5 LRP6 RHO CP PMC5312537__F6 Changes in upper glycolysis, glycerolipid metabolism and pentose phosphate pathway during aging FBP1 GPD2 HEL-S-87p HEL107 PFKP HK2 GPD1 HEL-S-162eP PMC5843704__F8 Proposed model for the role of DAPK1‐mediated Beclin‐1 phosphorylation and TTP‐mediated Bcl‐2 mRNA destabilization in autophagy leading to the suppression of inflammatory responses by gAcrp in macrophages ADIPOR1 TRAF6 MYD88 PMC1551980__F1 Ubiquitin Signaling in the NFKB Pathway TRAF5 RELB REL TRAF2 PMC9035186__F3 Signaling cascades in the failing heart and emerging therapeutic strategies ARC FADD PMC9224119__F1 TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 PMC8037234__F3 E2s participate in the DNA repair pathway RNF8 RNF20 FANCD2 UBE2T PCNA PMC10036296__F1 An Evolving Understanding of the Basis and Management of Vascular Complications of COVID-19: Where Do We Go From Here? CRP VWF ACE2 PMC12059369__F5 Key signaling pathways involved in the therapeutic mechanism of andrographolide (AD) in diabetic nephropathy (DN) NPB EGR1 BAD ATF2 MYD88 TNF MMP2 VCAM1 APP REST SELE TF STAT3 PMC3202988__F1 Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells OGA OGT PMC7984363__F2 HIF regulation and function on POMC TSC2 POMC TSC1 NPY AgRP MC4R VHL EIF4E TNF RHEB PMC12238214__F6 Hepatocyte nuclear factor 4-Alpha: a key regulator in liver carcinogenesis HNF4A IL6 PMC12238214__F5 HNF4A Downregulation Drives Hepatocellular Carcinoma Proliferation and Genomic Instability: Downregulation of HNF4A promotes HCC progression through key molecular pathways HNF4A CCND1 PMC6029659__F6 H2S targets key host factors and viral steps to perturb replication of enveloped RNA viruses TRADD KEAP1 IRF3 SP1 PMC8020248__F2 Dysregulated MET activation, signaling pathway, and tumorigenic consequence PI3 IGF1R HGF EGFR GRB2 PMC6190278__F1 Heterologous effects of infant BCG vaccination: potential mechanisms of immunity CD14 EGF TLR4 MTOR CD69 PMC5386972__F2 MYC promotes anabolic metabolism MYC HEL-S-133P HK2 PMC8037234__F5 E2s participate in the NFKB pathway TRADD HEL-S-71 RELB TRAF3 TRAF6 TNF UBE2V1 BCR TRAF5 CYLD CD40 TRAF2 LTBR PMC5683310__F2 Molecular pathways regulated by ZNFs in physiological conditions KDM1A CTBP2 PPL CTBP1 HOMER3 KLF5 MYBPH HDAC1 RBBP8 MYOM2 RCOR1 PKP1 ZNF750 CDSN SPINK5 KLF4 FLG MYL4 PPARG MYOG PMC6664754__F2 Proposed model of the Lgr5-mediated stimulation of cancer growth through activation of the Wnt/Beta-catenin signaling pathway LRP5 CCND1 LRP6 GPR49 PMC8496198__F7 PI3KG/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization CD44 ARHA MTOR PMC9322180__F1 Genetics in Familial Intrahepatic Cholestasis: Clinical Patterns and Development of Liver and Biliary Cancers: A Review of the Literature PC NOTCH1 FGF19 FGFR4 CYP7A1 CFTR PMC6738120__F1 BRAF pathway BRAF EGFR GRB2 PTEN MTOR PMC5549800__F6 Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors TSC2 TSC1 PC ELF3 EIF4E RPS6 EIF4B DDIT4 RHEB PMC6406361__F7 Main steps of arginine metabolism OTC ASS1 ASL PMC6943877__F1 Pattern recognition receptors and inflammasome sensing mechanism during influenza A virus (IAV) infection STAT1 NLRP3 TLR7 STAT2 IRF9 MYD88 IL1B TLR3 MAVS PMC9479306__F1 Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications SMAD2 ZEB2 APC TGFBR1 DROSHA TGFBR2 SMAD4 ARHA CDH2 CDC42 PMC7104260__F1 Internal cues and the mating-pheromone-response pathway converge on the activation of Cdc42 FAR1 POLE RAX2 CDC42 PMC3429544__F8 Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition ERAL1 DRAM1 PMC2989726__F5 CFTR Chloride Channel in the Apical Compartments: Spatiotemporal Coupling to its Interacting Partners NHERF2 LPA CFTR PMC6406361__F1 TNF-related apoptosis-inducing ligand (TRAIL)-induced signaling pathways CASP3 RIPK1 CASP9 RIPK3 MAP3K7IP1 TRAF2 FADD MLKL TAB3 PMC6743792__F7 Executable pathway analysis using ensemble discrete-state modeling for large-scale data PIK3CD PIK3R1 MAPK9 MAPK8 FLNA MAPK3 GSK3B FLNB ARHGAP35 CRKL PDPK1 PRKCA PI3 FLT1 VAV3 FYN MAPK1 HEL114 ARHGAP5 RAPGEF1 ROCK2 SOS2 HEL-S-28 VAV1 IMPACT PIP5K1C CRK PIK3R3 PPP1CC HEL-S-80p PAK1 PRKCB RAP1A ITGA6 THBS3 ZYX GRB2 MYL12B BCL2 ITGAV MYLK4 MYLK ACTG1 AKT3 CDC42 IGF1R VASP BAD BRAF ROCK1 ACTN1 sm-M20 TLN1 ITGA4 CCND3 CCND2 MYL12A BIRC3 ACTN4 JUN ITGA1 PARVG ARHA RAC1 ITGB1 PS1TP5BP1 BIRC2 MAP2K1 ITGB7 ERBB2 PIK3CA RAF1 SOS1 VEGFB SHC1 PXN PIK3R2 PMC7937231__F8 Bacterial invasion of epithelial cells pathway (KEGG ID:hsa05100) in the CoPS vs CLTA WASL HEL-S-28 ARHA HEL114 CRK CBL PMC5751331__F1 Lysophospholipid-mediated PPARG signaling PC PLD2 LPA ROS1 PMC2782452__F1 Different views of the Akt pathway/network BAD MDM2 TEC PTEN MTOR PMC7540110__F1 Cell cycle regulation through cyclin E SOX2 CDK2 CDK4 CDK6 PMC7033644__F2 EV trafficking between leukemia and stromal cells reduces sensitivity to chemotherapeutics CXCR1 PC BMP2 MSC IL8RB PMC2644070__F2 Homologies between mammalian and insect immune defense pathways TRADD TRAF1 TRAF6 IRAK4 TRAF2 FADD PMC5290198__F7 BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling NOTCH1 IL6 BRD4 PMC3616609__F2 The multi-step pathway of CENP-A-containing centromeric chromatin replication utilizing sequential, temporally separated steps across the mammalian cell cycle ECT2 CDK2 APC HJURP CDC2 CDC42 PMC7146499__F2 Dehydration alters hippocampal transcriptional networks CSRNP1 GAD2 IRAK1 MBP SYNGAP1 GAA ARPP-21 PYGM CYP51A1 DLG4 PPP1R9A DNAJC21 PICK1 SRC JUNB GPD2 BTG2 HEL-S-133P AFDN APOE BHLHB2 RELN FOS DLG2 VEGFA GRIA2 EGR4 AVP NRXN1 ARC SIAH2 BDNF LYPD1 TH HSD17B12 SDCBP C1orf51 CASK SIK1 CAMK4 NLGN3 ZFPM1 PER2 DLGAP1 MIDN PFKL KALRN DNAJB5 SLC50A1 PMC8316210__F8 Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1B Signaling Pathway NRF1 GABPA PMC3635124__F1 Shh signalling pathway1 HHIP BOC CDON KIF7 DISP1 KIF3A FUZ INTU GAS1 IFT172 IFT52 SAP18 IFT57 SUFU PTCH1 GLI3 DYNC2H1 SHH SMO SPOP ADRBK1 C2CD3 PMC2859499__F7 TAK1·TAB2·NLK complex negatively regulating canonical Wnt pathway NLK LEF1 PMC12133520__F2 Thymus cell development and regulation mechanism RUNX3 GIG8 NFIL3 GATA3 PMC5666637__F5 Transforming growth factor B (TGFB) and bone morphogenetic protein (BMP) signaling in bone homeostasis MMP2 RUNX2 SOST MMP9 PMC5666637__F3 Summary of the bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathway and mutations causing connective tissue and skeletal disorders RUNX2 SOST LRP5 LRP6 SMAD1 DKFZp781O1323 PMC3276354__F1 Canonical Wnt (Wnt/Beta-catenin) signaling pathway (adapted from Ref APC SOST GSK3B TEF LRP5 LRP6 MTOR RHEB PMC4355017__F6 Drugging the undruggable Ras: mission possible? ME1 HEL-S-30 ENO1 RPIA RPE HEL-S-133P GLUD1 HEL-S-32 PMC6085474__F7 Regulatory pathways of ERBB2+ GC RARA ERBB2 MYC NRG2 PMC6890986__F1 Apoptosis and necrosis pathways RIPK1 RIPK3 MLKL BAX PMC6890986__F3 Mitochondrial apoptosis pathway BAD BIK BMF HRK BAX PMC6890986__F7 Pyroptosis NLRP3 MAVS GSDMD PMC12070581__F9 Map of specific pathways under imazapyr acid stress FEN1 SVIP LIG1 PCNA PMC7072176__F3 Viral miRNAs affect the pathways involved in the carcinogenesis of host cells CASP3 RUNX1 CASTOR1 PTEN PMC6447583__F8 Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge HES5 IGF1 PMC6491837__F2 Positive and negative feedback signals for neuronal polarization TIAM1 NUMB PAK1 SEMA3A IGF1 LYN ARHA RHO CDH2 BDNF CDC42 PMC6604281__F1 Fanconi anemia curated map, based in the KEGG FA pathway PALB2 FANCD2 POLK WDR48 PMS2 BRCA2 FAAP24 ATRIP FANCM RAD51 RFWD3 REV3L ATR RAD51C PMC3701722__F1 Autophagy and endocrine resistance in breast cancer ULK1 ATG12 MTOR DKFZp686F0183 PMC8490548__F2 MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility DHFR PMC11939858__F1 Influence of RANKL, sclerostin, and DKK1 on glucose metabolism and the corresponding signaling cascade CXCL1 DPP4 APC TRAF3 LRP5 LRP6 DKK1 MTOR PMC5871764__F2 Notch pathway CTBP2 KAT2B NUMB CTBP1 LFNG HDAC1 HES1 DTX3L HES5 CREBBP PSEN1 HDAC2 APH1B PMC5871764__F1 Notch pathway CTBP2 KAT2B NUMB CTBP1 DTX2 MFNG HDAC1 HES1 DTX3L HES5 CREBBP PSEN1 DVL2 HDAC2 APH1B PMC3871277__F1 Panitumumab and epidermal growth factor receptor (EGFR) signaling pathway EGFR GRB2 SHE MTOR PMC6893313__F8 Representative model of the MMP-2 and MMP-9 secretion induced by leptin in a cultured model for breast cancer SRC STAT3 PMC8197283__F2 WNT4 Balances Development vs Disease in Gynecologic Tissues and Women’s Health WNT4 EHD1 BMP2 IGFBP1 LEFTY2 FZD2 HOXA10 FOXO1 PRL PMC4518644__F5 Example of using “Effect on Metabolism” tool to see the overall proteome result mapped on carbon fixation metabolism OMD KEL MAL PMC4518644__F4 Example of using “Inter-pathways” tool to query interactions between two pathways (left─syn00710: Carbon fixation; right─syn00480: glutathione metabolism) LAP3 CP EED PMC6801436__F2 JAK1-TYK2 heterodimer signaling pathway STAT1 STAT2 TYK2 JAK1 IFNG PMC9358975__F1 Correlation Between MicroRNAs and Diabetic Retinopathy ATF4 CYC1 NOTCH1 MMP21 PMC7311964__F1 Wnt pathway drug targets MESD APC SFRP1 PMC9185696__F1 Interplay of retinol binding protein 4 with obesity and associated chronic alterations TLR4 SOCS3 MAPK6 VCAM1 MAPK3 RBP4 TRAF6 NOX4 FIS1 PMC8402498__F9 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions HEL-S-11 MYC PMC3552883__F8 Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells MAPK3 MAPK1 MCL1 DKFZp686F0183 PMC3653120__F4 Effect of physical activity and obesity on the growth and development of colon carcinogenesis GSK3B MYC TNF PCNA PMC3653120__F3 Effect of cigarette smoke on the etiology of colon carcinogenesis BRAF EGFR PMC1681473__F1B (B) The bow-tie architecture also exists at the signal transduction level TH CD6 HEL-S-92n IRF3 IL6 MYD88 TNF TLR3 STAT1 LTA TLR7 TLR4 STAT4 GATA3 TIRAP PMC4684962__F5 Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer KEAP1 SMAD4 IL6R CELSR2 KSR1 WNT8B CSTF3 CNOT4 PMF1 PRKX B9D2 SDCCAG8 SNAP23 IL10RB RICTOR VAMP2 HOMER2 MED16 PDE4B SUFU STK11 NR1C2 SCNN1A HEL-S-36 AKT3 ACVRL1 TBL1X LRP8 PPP2R1A TFRC KDELR1 INPP4B CELSR3 PARVA ADAM17 CEBPB C1QA U2AF1 PDGFA SFRP1 CXCL6 FGF7 MED25 STARD8 NDUFS6 AATF MAFF ADRA2C SIN3B ASAP2 STAG1 CD79B PRPF6 GNG12 CIB2 GIG8 ERBB2 STM7 NUMA1 KDELR3 RAB27A ETV4 NUP62 PMP22 SMARCC1 SMARCA4 CD8B GCS1 MIA CEP41 TRIO ELMO1 TUBA8 ELK3 LIMK1 ARHGEF7 PLAUR PCDH8 DCHS1 FGF17 STAG2 NDE1 ADAR ZYX TGFBRAP1 TNFRSF18 U2AF2 ITCH SUPT5H HEL-S-62p ITPR2 ADD1 TUBA1C SYBU NCKIPSD FOXA3 PRKDC MED24 MYO1D NMT1 DVL3 GATA2 TYROBP CD72 CLTCL1 HNRNPC SLC34A3 CLNS1A NUP98 NKAIN1 hCG_2014051 NKAIN3 CGNL1 MED26 SRSF11 SMAD1 FAM13B SYT2 DNAL4 BRF2 DDX54 CDK5RAP2 POLR3A TLR9 CDH24 STX1A TCF12 FLNB COLGALT1 SF3A1 TADA2B KHSRP LINGO1 ABL2 ACTG2 PLA2G6 DDB2 GPLD1 ARID1A PIK3R5 EDN1 EDNRA IGFBP2 YY1 XPA CLTC PRKCH PLCG1 NUMB IFITM3 PSMD9 SIK3 SSU72 CNOT1 EIF4E1B IFNLR1 CXCL13 COL17A1 ASIP MED13L PDCL AKAP9 IL2RB RHOBTB1 HNRNPR TUBGCP6 RPA1 KLKB1 PRKD1 IKBKB KALRN LCK SHC1 ID4 GRIN3A GAA CKAP5 BMPR2 ACVR2B POLA2 PIKFYVE RAD52 PCK2 NDUFS8 IRF2 GANAB LAMB2 GNG3 MCM3 ISG20 NDUFB7 NR2C2 MED13 ERC1 PTP4A3 PML ARFGAP3 CREB3L2 TBL1XR1 ATP1A1 PLOD1 AP1B1 ARHGEF2 MTOR APTX PAG1 NKD1 PRNP ARHGAP1 GNG4 NUF2 PLAT DRAP1 NGFR KNTC2 CPT1C SOCS4 TLR5 NDUFB11 EGR1 DAAM2 SDC1 NFE2L2 SCNN1D CAMK2G STX1B CAB39 NAPA CPSF2 ADORA2A NDUFB1 SPI1 NFKB1 NDUFA3 EDN2 GRAP2 PTPRE JAK1 REL GRB10 SLC1A3 ACOX3 PIK3R2 PMC9338328__F2 Radiotherapy combined with immunotherapy: the dawn of cancer treatment SMAD4 STAT3 FOXP3 PMC9338328__F5 Radiotherapy combined with immunotherapy: the dawn of cancer treatment CCR2 CXCR4 CCL2 CXCL12 STAT3 PMC9338328__F6 Radiotherapy combined with immunotherapy: the dawn of cancer treatment TBK1 CGAS CCR2 IRF3 CCL2 STAT3 PMC6128898__F9 Expression patterns of T SQLE FDFT1 IPP PMC7814595__F3 Different T cell subsets infiltrate the injured brain IL16 AREG CXCL9 PMC5536086__F1 Proposed model for UCP2-SIRT3 (uncoupling protein 2-sirtuin 3) signaling pathway on cerebral ischemia–reperfusion injury ROS1 UCP2 SIRT3 PMC8255631__F2 Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation IL13 APC CD80 CTLA4 IL4 PMC7814595__F2 Functions of T cell subsets in the acute and chronic phases after ischaemic stroke IL10 AHR AREG PMC7531772__F5 Genome of the Softshell Clam Mya arenaria and the Evolution of Apoptosis BAD AIP CASP12 NGF TRADD CASP2 CASP10 HRAS DIABLO HTRA2 ATM ATF4 EIF2A CASP9 CAD TRAF2 CASP8 FADD HRK BAX PMC5666637__F2 Summary of the transforming growth factor B (TGFB) signaling pathway and mutations causing connective tissue disorders SMAD2 SMAD4 SKI PMC5312359__F7 MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells NF1 HOXD10 PMC3924561__F1 Functional Relevance of Biased Signaling at the Angiotensin II Type 1 Receptor BAD EGFR HBEGF ARHA EIF4E PMC7017938__F1 Opioid activity in cancer COX2 TIMP1 MMP2 MMP9 EGFR RHO STAT3 PMC6541264__F2 Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs NPM1 HEL-S-1 FLNA ATF2 MAPK3 SMAD2 MAPK14 BMI1 UNG XRCC5 MCC SRC IQCB1 HSPA4 MAP3K1 NCL TUBB FOS ADRB2 RNF2 FBXW11 CRK BRCA1 HLA-B NEDD4 HLA-C RXRA CALM1 MCM2 STAU1 VCAM1 CDK2 TNFRSF1A GRB2 CLTC HEL113 VCP TERF1 CSNK2B PCNA IKBKE IKBKG BTRC HEL2 HSP90AB1 EGFR PPP2R1A ITGA4 DKFZp686L0365 UBC APP YWHAG PRKDC JUN RUVBL2 SOX2 HEL-S-30 NTRK1 NR3C1 VHL HUWE1 SMURF1 HDAC1 AURKA FUS PS1TP5BP1 CFTR HEL-S-162eP EED HEL-S-102 SIRT7 CREBBP EP300 COPS5 RELA RPL10 TRAF2 HEL-S-93 SHC1 STAT3 PMC5700130__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes from transcriptome data with substrates and products, colored arrows connect substrates to their corresponding products IDI2 IDI1 IPP GGPS1 PMC8584528__F1 Model Identifies Genetic Predisposition of Alzheimer’s Disease as Key Decider in Cell Susceptibility to Stress ATF4 EIF2A XBP1 PMC12246121__F11 Translation regulations in PRRs ELF2 ELF3 EEF2 EIF5A MAP3K8 CLEC4E EIF4E TIA1 TNF MTOR TICAM1 PMC3343135__F2 Differential expression of mRNA and proteins encoding factors in the Notch signaling pathway NUMB PMC5992987__F4 Putative signaling pathway composed of FOXM1, MYC and miR-34a MYB PRR11 FOXM1 MYC MTFR2 CCNE1 LMNB2 IGF2BP3 E2F2 RRM2 EZH2 CENPA CCNE2 PARP1 CENPE NOP2 HDAC1 BRCA1 MCM3 UBE2C MCM5 NEK2 KIF20A PHF19 PCNA SKP2 PMC12246121__F14 PRR in ageing HMGB1 CGAS TLR5 TLR4 TLR9 IRF8 PMC9106063__F7 ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NFKB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation NLRP3 CD14 TLR4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 IL1B PMC7573235__F4 Signaling pathways activated by AKT1(E17K) PIM1 IGF1 PIM2 HEL-S-28 TRAF6 PTEN IRS1 PMC7573235__F3 Signaling pathways activated by AKT PIM1 IGF1 PIM2 HEL-S-28 TRAF6 PTEN IRS1 PMC8391653__F2 Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation HEY2 COL3A1 SUFU SMAD2 ADA SMAD4 LRP6 SMO RHO COL1A1 HES1 PMC1783691__F1 Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus APC CD40 ICOS PMC6338529__F1 VGF/BDNF/TrkB autoregulatory feedback loop stimulates synaptic plasticity changes in response to rapid-acting antidepressant treatment EEF2K AGO2 VGF BDNF PMC4172882__F1 (Rspo)s in canonical Wnt signaling pathway and the general architecture of (Rspo)s TEF CR2 PMC2826212__F2 An intricate gene regulatory network controls OL differentiation HES5 GIG8 ID4 OLIG1 YY1 TCF7L2 HDAC2 SOX10 HDAC1 OLIG2 PMC3646863__F4 Prognostic signature of G₂ checkpoint function in melanoma cell lines HERC2 CTDSPL2 HSF4 FBXO5 SETDB2 ATF2 DOCK10 MMS22L PSMD7 MNAT1 YPEL4 ATM FOXA1 WDHD1 CDC2 JUN PTPRM TWSG1 KAT2B KIT DAAM2 APC CDC25B CKS1B PSMB6 HEL-S-42 ATR ANKRD28 PMC9016174__F1 Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis APC GSK3B PMC6245608__F3 Physiological regulation of autophagy in the heart ULK1 TFEB FOXO3A F3 IRS1 FOXO1 RHEB PMC3988467__F1 Amino acid signalling upstream of mTOR DEPTOR RHEB MLST8 PMC8576330__F6 Involvement of the TGFB Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis TWIST2 MMP2 MMP9 IL11 TBR1 PMC6309606__F6 RAS/ERK, PI3K/AKT, WNT and Beta-catenin signaling pathways are involved in different stages of brain development and are commonly disrupted in ASD TSC1 GSK3B PTEN PMC2826040__F5 miR-223 is implicated in the CREB signaling pathway IGF1R IGF1 GPR108 CACNA2D1 PMC2826040__F4 miR-200a is implicated in the type I interferon signaling pathway STAT2 STAT4 IFNAR1 PMC10526530__F2 What General Neurologists Should Know about Autoinflammatory Syndromes? IL10 NLRP3 CGAS IL18 MVK TREX1 OTULIN SMS NOD2 PSTPIP1 PMC6338642__F7 BMP4-mediated anti-cancer effects in ER+ breast cancer SMAD4 CCND1 CDK4 SMAD1 CDK6 DKFZp781O1323 BMP4 PMC8851529__F5 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents EGF EPO VHL TFRC PFKL EIF4E HEL-S-87p MTOR HMOX1 HEL-S-162eP EDN1 TLR4 TF STAT3 PMC5067143__F2 (Opposite and overleaf) Visualizing drug action STAT1 EGF EGFR PMC5647276__F2 Daily and annual timing share neurobiological and molecular pathways TEF EYA3 HLF PMC10874285__F2 Interplay between HCV-induced autophagy and host innate immune response TBK1 CGAS TRAF6 IRF3 PMC11707604__F3 Signal transduction via interleukin (IL)-4R complexes and mechanism of action of dupilumab TYK2 JAK3 JAK1 PMC8851529__F2 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents CTSG CPA3 REN MRGPRD CTSA CMA1 ACE2 MME MLN PMC10874285__F1 HCV inhibits the innate immune response TBK1 CGAS SOCS3 TRAF6 IFNAR2 MYD88 IFNAR1 MAVS SOCS1 PMC11707604__F1 Severe asthma immunopathogenesis in type 2 (T2)-high asthma and the specific targets of biologic therapies IL33 IL25 TSLP PMC7274521__F6 Schematic description of resveratrol-mediated suppression of inflammation in IL-1Beta-induced SW1353 cells IL16 TLR4 MYD88 PMC7267026__F3 Positive and negative regulation of MAVS activity antiviral immunity UBXN1 TRIM21 TRAF3 TRAF6 NLRP11 RAC1 SMURF1 FAF1 NLK TRAF5 OGT TTLL12 OTUD4 TRAF2 MAVS PMC7267026__F2 RLR signaling pathways TRAF5 IRF7 TRAF3 TRAF6 IRF3 TRAF2 MAVS PMC9048811__F2 Epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease SNCA PINK1 LRRK2 NRF1 PUM2 TET2 SIRT3 PMC3689575__F1 Modeling the genetic basis for human sleep disorders in Drosophila LBR RALA CSA2 REL AMN RDX PLAC1 PMC5347907__F3 Functional long noncoding RNAs (lncRNAs) in inflammatory pathways COX2 HNRNPAB TLR4 HNRNPL SFPQ TLR3 PMC8281237__F1 Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias CTH BCAT2 SHMT1 PAH PHGDH BCAT1 PSAT1 ASNS PRODH PSPH HEL-S-51e ASS1 ASL GLS PMC9130726__F1 Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection IL18 TNF IL1B PMC8076548__F8 Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway STAT1 STAT4 JAK1 STAT3 PMC6997398__F7 Pathological biological network construction of high calorie diet combined with pneumonia GHRL CRP PSAP IL6 CCL2 CXCL12 HMOX1 NR1C1 METRNL SIRT1 PRL TRIO PMC4444189__F6 MicroRNAs Regulate Cellular ATP Levels by Targeting Mitochondrial Energy Metabolism Genes during C2C12 Myoblast Differentiation NDUFS4 COX6A2 COX4I2 NDUFB7 NDUFS5 PMC6997227__F2 PI3K/PIP3 signaling activates Akt signaling via Akt/PDK-1 activation, which results in the downregulation of apoptosis IGF1 PTEN IRS1 PMC6429226__F5 Apoptosis can be modulated by the activity of polyphenols in prostate cancer HEL-S-62p BAD C9 APAF1 BIK C7 C6 BMF FADD BAX PMC6429226__F3 The effects of polyphenols on signaling pathways in prostate cancer EGF HGF IGF1 APC GSK3B SRC PTEN TF PMC8998814__F4 Metastasis and MAPK Pathways EGFR RAC1 CDC42 PMC8998814__F3 Metastasis and MAPK Pathways EGF SMAD2 EGFR GRB2 SMAD4 TRAF6 TBR1 RHO MTOR FOXC2 CDC42 PMC2818318__F4 Regulation of Cell Cycle and RNA Transcription Genes Identified by Microarray Analysis of PC-3 Human Prostate Cancer Cells Treated with Luteolin CCNA2 PLK1 CDKN1B PI15 GSK3B CCNH RB1 CCND3 TFDP1 CDK6 CCND2 CCNE1 CCNB3 CDC6 WEE1 CDK2 CCNB2 CCNB1 CDK4 PCNA RBL1 SKP2 CCNE2 PMC8998814__F5 Metastasis and MAPK Pathways FOXC1 FGFR1 SOX13 ATF2 PPP2CA ATF1 SOX4 PMC8211510__F1 Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway DCD CTRL PMC5905170__F1 Summary of the workflow followed in the present study SET PMC9263770__F9 Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice IL10 IL6 TNF IL1B PMC8909699__F2 Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy FLT4 FOXQ1 FGFR4 SOX18 MTOR SOX17 SOX7 SOX9 SOX4 SRY FGFBP1 SOX13 FRS2 CYLD SOX11 SOX12 CCND1 FZD7 SOX30 ABCG2 BAX SOX2 SGF29 SOX8 CXCL12 SOX6 PMC5024698__F8 Mechanism for HKa-induced endothelial apoptosis and inhibition of angiogenesis CSK LCK PAG1 PMC4580722__F2 Regulation of autophagy by amino acids ULK1 BAD AMBRA1 PTEN ATG101 DEPTOR TSC2 RS1 TFEB MAP4K3 IPMK UVRAG BNIP3 ATG14 PMC4580722__F1 Autophagic machinery ULK1 WIPI1 LAMP2 AMBRA1 WIPI2 ATG101 ATG14 RAB24 PIK3R4 PMC3340168__F13 Apoptotic and necrotic targets modulate viability of epithelial responder cells by eliciting multiple recognition-dependent signaling pathways BAD GSK3B CCND1 PMC7848376__F6 A, On the left, the Neurotrophin signaling pathway (modified from KEGG hsa04722), showing genes targeted by miRNAs (n = 15) involved in its modulation BAD RIPK2 BAX PMC4032270__F3 Oak Root Response to Ectomycorrhizal Symbiosis Establishment: RNA-Seq Derived Transcript Identification and Expression Profiling MYB CS F2 TF PMC7848376__F5 A, On the left, HIF‐1 signaling pathway (modified from KEGG hsa04066), showing genes targeted by miRNAs (n = 16) involved in its modulation BAD IL2 FADD BAX PMC3577904__F3 Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice FHL1 EGR1 CASQ1 FOS HOPX NPPB ACTA1 FHL2 HEL-S-273 RCAN1 PMC5363613__F6 Integrin A2B1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma CCND1 AXL FAT4 PMC7787797__F8 PTP1B in IFN-Gamma-induced neuroinflammation and 6-OHDA-induced neuronal death ELF2 ELF1 SUI1 BDNF PMC8235304__F1 Opportunities for Ferroptosis in Cancer Therapy GCLM GPX4 FACL4 GCLC SLC7A11 HEL-S-64p SLC3A2 IPP HMGCR PMC11009036__F1 Nonsense-mediated RNA decay pathway UPF2 SMG1 EIF4A3 UPF3B MAGOH SMG6 SGA56M SMG5 PMC8844686__F6 Transcriptome analysis of inseminated sperm storage tubules throughout the duration of fertility in the domestic turkey, Meleagris gallopavo GNPAT DHX58 PGR IFITM3 C1QTNF4 CMPK2 CA8 ITGA4 ITGA2 OASL CCND1 GBP3 NMI SAMD9L RSAD2 IRF7 VEGFA STC1 CA9 CALHM6 TLR3 IGF1 EPSTI1 CSF1 EPHB2 PMC1992444__F3 Interaction map of the Notch signaling pathway PSEN1 LFNG HES7 MESP2 IFNG HES1 PMC3373577__F4 Increased Levels of BAFF and APRIL Related to Human Active Pulmonary Tuberculosis TNFRSF14 MAPK8 MYC TRAF3 TNFRSF13C IFNG GPC1 FCER1G TFG CRP CD40LG FURIN IL10 TNFRSF11B TNF RTN4R BCL6 CASP3 NFKBIA HNF4A SDC4 NFKB2 RELA TNFRSF1A CD40 REL PMC4609028__F1 Cell Cycle Regulators and Cell Death in Immunity ATM ATR PMC9511043__F4 Function and mechanism of histone Beta-hydroxybutyrylation in health and disease HDAC2 ACSS2 BDNF HDAC1 PMC7867063__F2 Roles of NRF2 in cancer metabolism ME1 GCLM GCLC HEL107 MTHFD2 PMC9196267__F3 Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials MAF TLR4 KEAP1 GSK3B APP ADAM10 BAX PMC4161521__F6 NFAT5/REDD1/mTOR/Notch pathway model TSC2 TSC1 NFAT5 PMC11065696__F7 Mechanistic scheme of UBB in ccRCC VEGFA SP1 UBB PMC3996587__F1 Extended model for the cyclin/Cdk network driving the mammalian cell cycle CDC20 WEE1 CDK2 CDC2 SKP2 PMC7912633__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets in the canonical pathway (adapted from [,,,,,,]) COX2 MT3 BCR RELA CRP GPX1 PMC7560826__F1 Janus-like role of proline metabolism in cancer PYCR2 PRODH PMC12222209__F3 Aberrant localization of glycolytic enzymes on cancer MDR KAT5 HDAC3 EGFR ENO1 HEL-S-68p HEL-S-162eP ATM CMTM6 PGP BCL2 ABCG2 EZH2 PFKP ABCB1 HEL-S-133P PCNA HK2 BAX PMC9011221__F3 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review HEL-S-89n GPX4 SLC7A11 ATF4 HEL-S-64p ATF3 BAP1 PMC7560826__F3 Janus-like role of proline metabolism in cancer ATF4 PRODH MTOR STAT3 PMC7560826__F4 Janus-like role of proline metabolism in cancer PYCR2 APAF1 PRODH FADD BAX PMC7576031__F2 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review EGF CD44 CXCL8 STAT3 PMC3064425__F2 Dietary agents on the extrinsic and intrinsic pathways of apoptosis in prostate cancer TNF FADD BAX PMC3518132__F8 Alkylphospholipid (ODPC)-induced raft-based inhibition of cell signaling LAT2 GRB2 PTEN LAT PMC7576031__F3 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review ZAP70 MTOR LAT STAT3 PMC6258166__F6 Brain hyperserotonemia and Sert knockouts LIPC HTR1B RUNX2 EGFR MAPK3 KIF12 FBXO24 CREB1 OXCT2 VILL DENND2D SSC5D HTR1F ANKFN1 STAT5B AGBL3 FGF23 ALG3 PICK1 MAPK1 CCL19 TRIM68 ABCC6 SP1 JUN RHBDD1 BMP3 TFPI CNKSR3 KCTD11 MPG CPB2 IGF1 SPATA2L CP CRB1 TERT PMC8999556__F4 New Perspectives in Treating Acute Myeloid Leukemia: Driving towards a Patient-Tailored Strategy KIT FLT3 PMC6953121__F6 Schematic representation of the molecular interplay between S1T-dependent ER Ca2+ leak, ER stress, BAPP processing, and neuroinflammation likely contributing to AD setting and/or progression BACE1 ATF4 EIF2A APP PMC8980928__F6 Synovial tissue‐derived extracellular vesicles induce chondrocyte inflammation and degradation via NF‐KB signalling pathway: An in vitro study ADAMTS5 IL6 PMC9436901__F8 Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway CARD9 BCL10 DKFZp686F0183 PMC4544949__F1 The flow diagram represents the sphingolipid metabolism pathways both in mammals and in yeast DES MIP SMS PMC7528698__F1 Transcriptional regulation of macropinocytosis AXL PMC8608863__F6 Molecular mechanism of Met against HCT116 cells CASP3 CASP9 CASP8 PMC3267756__F9 Coxiella burnetii Induces Apoptosis during Early Stage Infection via a Caspase-Independent Pathway in Human Monocytic THP-1 Cells TRADD FADD BAX PMC7600811__F13 Simplified representation of the Rho/ROCK signaling pathway FHOD1 RHO PTEN PMC4515393__F1 Ceramide metabolic pathways CERS3 LASS1 DES CERS5 SMS CERS2 CERS6 PMC4662490__F3 Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma PRCC GADD45G STEAP3 SFN RPRM DKFZp781B1423 CD82 MYC PTEN DDB2 CCNE1 TSC2 CASP3 PERP SESN3 ATM CDK2 MDM2 ZMAT3 THBS1 ATR CYCS BAX PMC7600811__F12 Simplified representation of the canonical and non-canonical Wnt signaling pathway ARHA RAC1 CDC42 PMC5772162__F2 Progranulin TFEB M6PR TMEM106B BDNF GRN PMC11489006__F3 Hippo pathway and crosstalk with other signaling pathways in CRC GIP TCF4 PMC11489006__F2 Upstream regulators of Hippo signaling pathway in CRC LATS1 LATS2 PMC11489006__F1 Hippo signaling pathway LATS1 LATS2 PMC5661614__F3 Simplified signaling pathway network where Wnt/Beta-catenin, Notch and Hedgehog pathways, along with critical transcription factors including Bmi-1, c-myc, Slug and Sox9, interact with one another and contribute to the maintenance of MaSC state BMI1 SOX9 PMC8630984__F1 Mapping the molecular architecture required for lipid-binding pockets using a subset of established and orphan GPCRs PTGER2 PTGIR PTGFR PTGER4 GPR32 FPR2 GPR34 PTGER3 LPA GPR87 GPR75 PTGER1 TBXA2R PTGDR PMC6249229__F5 13C metabolic flux analysis and RNASeq explain the overflow metabolism TAL2 ENO1 CIT tal-1 HEL60 HEL-S-32 HK2 MAL PMC8395233__F1 Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF VCAM1 SRC RAC1 IL1B PMC2839281__F4 Pigmentation Pathway Evolution after Whole-Genome Duplication in Fish KIT LEF1 ASIP DCT TYRP1 SOX10 PAX3 PMC9112456__F3 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives SUFU SMO TUG1 PMC9112456__F1 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives KIF7 SUFU GSK3B SMO ADRBK1 PMC3432272__F1 HIV’s double strike at the brain CCR5 CXCR4 PMC5003333__F1 Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms SMAD4 ENG KCNK3 NOTCH3 PMC5069093__F1 Regulation of TLR folding, trafficking, and cleavage TLR8 TLR7 TLR4 TLR9 PIKFYVE UNC93B1 MYD88 SCARB2 MAL PMC10909982__F5 Wnt/Beta-catenin signaling pathway potentially contributes to PTC progress APC CCND1 PMC2630471__F5 DAF-2 Insulin-like Signaling Pathway Independently Regulates Aging and Immunity INS PTEN SGK1 PMC6721659__F3 Signaling pathways downstream urokinase-type plasminogen activator (uPA) receptor (uPAR) and its co-receptors PLG VTN SRC RAC1 STAT3 PMC6997353__F2 Ferroptosis: past, present and future HEL-S-102 GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 ALOX15 IREB2 IPP DKFZp686F0183 PMC7214843__F2 RAD51-mediated RF reversal (A) and an overview of replication fork restart mechanisms (B) RAD51 WRN DNA2 POLD3 PCNA PMC5011625__F5 Endothelial Mechanosignaling: Does One Sensor Fit All? TIAM1 VCAM1 ARHA RAC1 PMC8400620__F5 Comparative Pan-Genome Analysis of Oral Veillonella Species ME2 PC DERA MCEE RBKS SDHB HEL-S-162eP PMC3563505__F6 Functional partners of RB1 protein through STRING database RBBP4 CDK2 E2F2 MDM2 CCND1 CDK4 RB1 TFDP1 HDAC1 E2F3 PMC7725906__F6 Action mechanism diagram of MXSG IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 MTOR TLR3 RHEB EMC1 STAT1 TSC2 TSC1 TLR7 TLR4 ACE2 EIF4B IRF-1 CASP8 IL1B FADD PMC9148527__F4 Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection TH BAMBI HGF NODAL SMAD2 TGFBR1 SMAD6 SMAD4 SKP1 ARHA TNF RBX1 LTBP1 CD81 IFNG FST TLR4 RAE1 DBP SP1 PMC8966751__F4 Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining MALL HEL-S-11 GC APP TRPC6 CNP SRC ARHA GATA4 PMC4226790__F1 Development of mononuclear phagocytes MAFB CX3CR1 CD34 PMC6879860__F3 Schematic of the components of the integrated model CRH MTOR CIT MAL PMC9596219__F7 DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway KITLG DAZAP1 PMC8899159__F5 Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model NR3A2 MYC HIF1A IRS1 FOXO1 RXRA IFNG NFKBIA NOS2 SP1 PPARG JUN TGFB1 PMC8213343__F1 Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies TLR9 RELB IRF3 MYD88 TLR3 IFNG BTK TLR7 TLR4 COPE BCR LYN CD40 SYK JAK1 CXCL12 IRF-1 CD19 MAL PMC5849056__F1 Complement System and Preeclampsia HEL-S-62p CD59 C9 CD46 MASP1 C7 C6 CD55 CR1 PMC3279748__F2 GSK-3 in NMDAR-LTD CASP3 BAD CASP9 RALA KLC2 RALB STAT3 BAX PMC9672095__F4 Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome SNCA ATP6 APC LPL ABO APP WAPAL MCU TNF BPI INSR PMC3432498__F1 Activation of the IKK-NFKB pathway by radiotherapy and chemotherapy ATM TRAF6 PMC2933845__F4 Genistein inhibits critical pathways in cancer invasion MAPKAPK2 SMAD1 PMC6925521__F1 NHEJ occurs at all stages of the cell cycle RNF168 INS BARD1 RAD51 BRCA1 PMC11512513__F3 Signaling pathway with UPS-related muscle wasting in cardiac cachexia IGF1R IGF1 TRIM63 IL6 TNF MTOR IRS1 PMC4795702__F2 Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I FHL1 RRAGD LMOD1 SMOC2 CTSS FLNA ACTA2 CSTB DES SLC22A3 PTGS1 SLMAP CLU DMD PLA2G7 KCNMB1 HEL32 CLUL1 IGSF6 PALLD TCAP MT2A TYRP1 CPVL BPI GPNMB APOE CD68 NAAA LRRK2 ACTG2 CTSK FTH1 CCL4 NRGN PIGK SYNPO2 TYROBP PLTP PCP4 LIPA HEL-S-273 SYNM MYLK SERPINB3 PMC6051722__F4 Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides and Incident Cardiovascular Disease LPL LDLR TG PMC11633002__F3 Network constructed based on the interaction test within the small cell lung cancer pathway from KEGG LAMB2 PMC7189798__F2 Death receptor and mitochondrial apoptosis signaling pathways and blocking TNFR1-mediated apoptosis by c-FLIP TRADD BCL2 TRAF2 FADD ITCH PMC6815639__F7 Pathview analysis of the NFKB signaling pathway NGF TRADD LTB MIP BOD1 IL16 LTA BCR ATM HEL-S-11 BIK LCK LBP CD40 SYK LAT TIRAP PMC9497241__F1 From Molecular Mechanisms to Therapeutics: Understanding MicroRNA-21 in Cancer AGO2 DGCR8 DROSHA RAN PMC11551531__F3 NFKB signaling pathway in macrophage polarization IRF3 MYD88 TNF PMC11551531__F5 Notch signaling pathway in macrophage polarization HES5 MYD88 HES1 HES2 PMC10334824__F5 Prospective application of lncRNAs in the treatment of diabetic wounds NLRP3 PTEN PROX1 EZH2 SOX9 PMC11551531__F4 JAK/STAT signaling pathway in macrophage polarization SOCS3 JAK3 SOCS1 STAT3 PMC12223783__F11 Exogenous spermidine inhibits trastuzumab-induced cardiomyocyte pyroptosis Schematic illustration of trastuzumab-induced cardiomyocyte pyroptosis, and exogenous spermidine blocking the action of trastuzumab by promoting mitochondrial biosynthesis TFAM GSDMD SIRT3 PMC11551531__F6 TGFB/SMAD signaling pathway in macrophage polarization SMAD2 SMAD6 PMC12112249__F2 MDK oncogenic signaling network NOTCH2 GPC2 NCL SDC4 ALK NOS2 MTOR STAT3 PMC7702235__F2 miR regulatory mechanisms in experimental VCID BACE1 SCN2A VAMP2 GSK3B CDK5 STX1A SNAP25 SYT1 PMC7251091__F8 Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway MMP2 PI15 MMP9 PTP4A1 SP1 PMC4051924__F5 Top-ranked signaling networks related to Na+/K+/2Cl- cotransporter 1 downregulation according to ingenuity pathway analysis JDP2 CDC20 PRC1 FANCD2 CDC6 E2F2 APC DES JUN CDC45 NCAPD3 SPC25 PMC7762932__F1 PC and PE biosynthesis via two branches of the Kennedy pathway PC CHKA CEPT1 CHKB TNK1 HEL-S-29 PMC3735985__F1 Simplified schematic representation of the insulin and TOR signaling pathways as they have been described in mammals and for which orthologous components have been described in D TSC2 TSC1 GRB2 PTEN PMC7312033__F2 IL-33, as pro-inflammatory and regulatory, on the central nervous system, liver, cardiovascular system, and pulmonary system IRAK1 IL33 TRAF6 HEL-S-70p MYD88 IL5 PMC4046645__F2 Overview of molecular pathways of oxidative stress and potential points of intervention in T cells in SLE IL2 MTOR FOXP3 PMC6033382__F2 Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients TREX2 TREX1 IL1R1 MYD88 PMC7432853__F2 Different mechanisms of crosstalk between pancreatic ductal adenocarcinoma (PDAC) cancer cells and cancer-associated fibroblasts (CAFs) IGF1 NODAL LIF SHH AXL PMC8706168__F9 Homophilic Interaction of CD147 Promotes IL-6-Mediated Cholangiocarcinoma Invasion via the NFKB-Dependent Pathway CXCR1 IL8RB CSA2 PMC10779012__F3 Mechanisms by which pitavastatin and metformin act to (A) turn cancer cells sensitive to chemotherapy and (B) help to revert the exhaustion state of CD8+ T cells MTOR HMGCR PMC10706934__F1 Hypothetic signalling pathway triggered by FK506 BMP10 SMAD1 DKFZp781O1323 PMC10779012__F2 Insulin-like growth factor 1 (IGF1) signaling pathway and major downstream effects on cancer cells BAD IGF1R IGF1 MDM2 MTOR PMC10779012__F1 Metabolism of cholesterol within an ovarian cancer cell SQLE FDFT1 ABCG1 LDLR ABCA1 HMGCR PMC9374094__F2 Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges IDO1 PC AHR PMC5055212__F6 Gene network construction LEF1 MAX MMP2 RALA LAMB2 SKP2 AKT3 PMC7413390__F5 Canonical pathway represented by differentially expressed proteins in the BALF between progressive and non-progressive sarcoidosis implementing Overlapping Canonical Pathway functionality in IPA RHO CDC42 PMC5452982__F3 Regulation of muscle growth and regeneration by the immune system HMGB1 MHC2TA PAX7 TRAF6 CCL2 MYD88 TNF IFNG STAT1 TLR4 CXCL9 NOTCH1 TRAF2 IRF-1 MYOG PMC3132181__F2 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry PML ATM CDK2 CDC2 ATR BRCA1 BAX PMC10745105__F6 Working model of GAH-dependent vascular repair SMAD4 MAP3K7IP1 SMAD1 DKFZp781O1323 SMAD9 PMC3132181__F1 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry ATM MDM2 RAD50 H2AX MRE11A BRCA1 BAX PMC8004487__F3 Role of sphingolipid associated loci in major sphingolipid metabolic pathways GLTPD2 SGPP1 SPTLC3 CERS6 PMC8834450__F2 Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review CYP46A1 CDK5 MTOR APOE BAX PMC10937367__F3 Effect of uridine on disease through O-GlcNAcylation GIG8 APP NEUROD1 MTOR FOXO1 PMC8148009__F3 Musashi–1—A Stemness RBP for Cancer Therapy? E2F4 CDC6 CDK2 E2F2 CDK4 DBF4 CHEK1 E2F3 CDC45 CDK6 SKP2 PMC7837592__F3 Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets EGFR SRC HEL-S-133P PMC6598292__F4 Main biosynthetic pathway for the biosynthesis of cellulose MAL PMC9029324__F2 Colorectal Cancer Diagnosis: The Obstacles We Face in Determining a Non-Invasive Test and Current Advances in Biomarker Detection ROCK2 BAMBI NLK LEP RHOD INVS APC SOST CER1 SMAD4 RYK PMC6712175__F10 Schematic depicting the role of the C/EBP-Beta-lcn2 signaling pathway in MA-induced microglial apoptosis LCN2 BCL2 CEBPB BAX PMC3270028__F6 Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling TBK1 IRF3 MAVS PMC6245940__F4 Dysfunctional HDL and atherosclerotic cardiovascular disease SCARB1 ABCG1 ABCA1 TG PMC6664293__F2 KEGG AD pathway CASP3 SNCA CASP12 BAD APAF1 GSK3B LPL CASP9 APP TNF FADD APOE PMC6664293__F4 Network visualization of the calcium signaling pathway with expression and GWAS information PDE1C PDE1B PPP3CA AGTR1 GRPR GNA14 RYR2 CACNA1A CACNA1C SLC8A2 PTGER1 CHRM2 NOS2 ADCY1 ERBB3 PRKX VDAC3 PDE1A HTR4 ATP2B1 PLCB1 CCKBR TRPC1 MYLK2 PRKCB PPP3R1 ATP2A2 HTR2A MYLK3 P2RX5 HTR6 P2RX2 PLCB3 SLC8A1 TACR1 TAC3 CCKAR DRD5 CACNA1S PHKG2 CAMK4 PLCE1 GNAL P2RX1 P2RX6 HRH2 CAMK2D SLC25A4 TACR2 SLC25A6 CCK ADRA1B CHRM3 ADRA1D TOMM40 CALML3 PMC2774770__F1 IL-4 induces an alternate pathway for BCR signalling BAD FOS ATF2 BTK BCL10 BASH LYN GRB2 SRC CASP9 SYK RAF1 JUN PMC6944396__F1 Schematic of the proposed pathways whereby mitochondrial dysfunction impacts chronic obstructive pulmonary disease pathogenesis PINK1 RIPK3 MLKL PMC7308236__F6 Electric Stimulation Hyperthermia Relieves Inflammation via the Suppressor of Cytokine Signaling 3-Toll Like Receptor 4 Pathway in a Prostatitis Rat Model TLR4 SOCS3 MYD88 IL1B PMC4515050__F2 Activation of complement system by the amyloid plaques and its dual role in neuronal death HEL-S-62p C1S PMC4905256__F8 Hierarchical protein binding at the rDNA locus and intersections with SUMO SMC2 NET1 SMC4 PMC7199433__F1 Mammalian kidney development RET EYA1 GDNF LHX1 OSR1 SIX1 WT1 SIX2 FOXD1 GATA3 PAX8 PMC7290425__F2 Breast cancer cells use HSFs to drive various tumor-promoting mechanisms RAB21 HSF4 ALG3 IER5 HIF1A HSF2 HSF1 PMC7290425__F3 Hepatocellular carcinoma (HCC) cells use HSFs to promote metabolic reprograming and cancer invasion HSF4 RECK FBP1 HIF1A HSF2 HSF1 HEL-S-133P HK2 PMC8778098__F1 Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors CGAS IRAK1 EIF2A TRAF6 IRF3 IRAK4 CASP8 PMC10993167__F2 Related regulators of N6‐methyladenosine (m6A), 5‐methylcytosine (m5C) and N7‐methylguanosine (m7G) are involved in the signalling pathways of drug resistance during tumour treatment MMP3 MMP10 METTL14 ALKBH5 HOXA10 WTAP STAT3 PMC10993167__F5 Molecular mechanism of action of the FTO inhibitor 18097 TIGAR PML IGF2BP1 FOXO3A GPX1 GLS2 GADD45A DDB2 ATG10 TSC2 SESN1 BTG2 SESN2 TPP1 EPHA2 SOCS1 COL4A1 BAX PMC10993167__F6 FTO, ALKBH5 and pseudouridine synthase partial inhibitors and their inhibitory pathways are introduced RARA IGF2BP1 ASB2 MYC CEBPA ALKBH5 SOCS1 PMC8814829__F4 Comparison of porcine milk microRNA expression in milk exosomes versus whole swine milk and prediction of target genes TSC2 BAD MEI1 BCR F2 MDM2 RAC1 BRCA1 RBL2 CD19 PMC4052186__F2 Cross-talk between mitochondrial metabolism and the IIS pathway is required to trigger the mitohormetic response in C PTEN PMC10976794__F3 Schematic overview of LMNA mutant pathways and MAPK3/1 (ERK1/2) initiated changes in cardiac remodeling FHOD1 DUSP4 YAP1 MAPK3 SHH MAPK1 LMNA MTOR WWTR1 JUN PMC6061680__F1 Toolbar, graphical elements supported in SPV and the mTOR pathway TSC2 INS PTEN RPS6 PPARG tal-1 RPTOR RHEB PMC10976794__F2 Schematic overview of the Hippo signaling pathway HEL2 SFN YAP1 HEL-S-1 TEAD4 LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 ARC HEL-S-93 PMC4068945__F4 Nrf2-mediated oxidative stress response pathway is altered at multiple levels by DNA methylation in COPD airways AOX1 EPHX1 KEAP1 FTH1 GSK3B GSTM1 JUND PTEN RBX1 MAFG PMC12187747__F2 ROS-induced cellular signalling in cancer cells BAD SRC PTEN SRXN1 BAX HEL-S-22 PMC6280103__F5 Cholesterol biosynthetic pathway and relative expression changes for genes encoding related enzymes SQLE EBP SC5D MVK IDI1 HMGCS1 HSD17B7 TM7SF2 HMGCR PMVK ACAT1 MVD DHCR7 FDPS FDFT1 MSMO1 PMC5003378__F9 Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems CD14 IRAK1 TRAF6 IRAK4 MYD88 REL PMC7925335__F2 Airway and small intestinal tuft cell signaling ITPR2 ChAT GNG13 GNAT3 ALOX5 LTC4S TRPM5 IL25 PLCB2 CHRM3 SI CHRM1 SUCNR1 CHRM2 GNB1 PMC471568__F2 Schematic illustrating the current working hypothesis on the hormonal servomechanism regulating uterine gland morphogenesis and function in the ovine endometrium during pregnancy PRLR GHR TYK2 JAK1 PMC11905258__F6 Potential therapeutic role of MSCs and EVs in treating CKD MMP3 HGF TIMP1 SMAD2 MSC MMP9 CCL5 CCL2 TNF PCNA CD1C PMC6448884__F5 GTS-21 has cell-specific anti-inflammatory effects independent of A7 nicotinic acetylcholine receptors TLR4 TRAF6 IL6 MYD88 TNF TRAF2 PMC4807992__F1 Prostate cancer stem cells: the role of androgen and estrogen receptors CCND1 SRC RAC1 DYRK1B PMC11545229__F8 ENAH-mediated OSCC progression EGF APC EGFR GSK3B SRC TF PMC2716750__F1 Gene regulatory networks in kidney development FOXC1 RET PAX2 GDNF SPRY1 ROBO2 SLIT2 FOXC2 FOXD1 BMP4 PMC4813636__F1 Direct and indirect inhibition of MYC NCL MAX MYC TRRAP BRD4 PMC9595552__F4 Pyruvate metabolism–original version ME1 ME2 ACYP1 HEL-S-30 ACACA ALDH3A2 ACSS2 ACOT12 ACYP2 MDH2 ACAT2 ALDH7A1 PC LDHD ACSS1 FH ACACB PKLR HAGH ME3 PCK2 DLAT HAGHL HEL-S-281 PMC2882796__F1 Does Activation of the Blood Coagulation Cascade Play a Role in Malaria Pathogenesis? VCAM1 IL1B TF PMC7697007__F7 TRIP12 in the DNA damage repair (DDR) pathway in response to DNA double-strand break (DSB) [,,,,,,] RNF168 RNF8 TRIP12 ATM BRCA1 PMC7697007__F6 TRIP12, ARF, and P53 pathway TRIP12 TRADD MDM2 PMC10559929__F5 Explain the correlation among the chemical components, candidate targets, involved pathways and corresponding pharmacological effects of AGNHW ANXA1 IGF2 MMP9 MAPK10 CXCL10 PARP1 TNF HMOX1 CEBPB HEL-S-22 STAT1 CASP3 RELA HEL-S-44 BCL2 ABCG2 PMC7911310__F1 Methionine metabolism HEL-S-61p HEL-S-182mP SRM AMD1 SMS PMC4097023__F6 Working model of apigenin-induced DNA damage FEN1 RAD1 ATM E2F2 MYC H2AX BACH1 PMC3696572__F1 Linking MLL and the HGF-MET signaling pathway in liver cancer HGF PMC12119490__F2 Tumor-derived vesicles and induced signaling modulation in various immune cells TLR4 ATF4 CXCR4 CXCL12 JUN STAT3 PMC6002513__F3 SIRTl/PGC-1A (FNDC5) pathway APP BDNF FNDC5 PMC10996278__F5 Major TCR signalling pathways CUL5 PLCG1 RNF7 ARHH CD5 FOS VAV1 UBASH3A DGKA ITK FYN BCL10 RELA LCK ZAP70 GRB2 DGKZ PTPN6 SLA2 JUN LAT SOCS1 CDC42 PMC9114485__F2 Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress ME1 SHMT1 MTHFD1 HEL-S-51e MTHFD2 PMC7419058__F1 P53 activity by FBXO22 during senescence FBXO22 PHF20 KDM4A PMC8804006__F1 Metabolic Transporters in the Peripheral Nerve—What, Where, and Why? PANX2 PANX1 HEL-S-133P PMC10996278__F6 Critical genes and signalling pathways engage in T cell anti-tumour responses CUL5 CARD11 SOCS3 BCL10 RELA TOX IRF4 LTBR SOCS1 GATA3 FOXP3 BATF PMC9040001__F6 Comparative transcriptomics discloses the regulatory impact of carbon/nitrogen fermentation on the biosynthesis of Monascus kaoliang pigments CS TG PMC2913631__F3 Schematic model of crosstalk between PPARG and Wnt-5a signaling in MSC NLK SETDB1 PMC8888930__F1 Microglia Polarization From M1 to M2 in Neurodegenerative Diseases TLR4 TRAF6 MYD88 SIRT1 PMC6462501__F2 Signaling network of the MSC components related to protein synthesis and cancer ATM SMURF2 VEGFA CDK4 MTOR ATR TRAF2 PMC8632544__F1 Wnt/Beta-Catenin-Dependent Transcription in Autism Spectrum Disorders APC LRP5 LRP6 ARHA RYK RHO JUN PMC11545787__F1 Effect of Probiotics on Gastrointestinal Health Through the Aryl Hydrocarbon Receptor Pathway: A Systematic Review AHRR AHR CYP1B1 CYP1A2 PMC3793056__F5 Predictive metabolic pathway of biosynthesis in M MTR STS DAP PMC2581573__F1 The IL-1 signaling pathway TRAF6 IRAK4 MYD88 PMC6462501__F5 Systematic association of the MSC components with mTOR and DNA repair pathways EIF4A2 PIK3R1 PML RRAGD RPA3 DDX1 GSK3B GOLPH3 MTOR ATP6V1E1 INSR ATM MAPK1 RAD51 XRCC3 SGK1 PRKAA2 RPA1 PIK3R3 EIF4G1 RHEB IKBKB AIMP2 TNFRSF1A GRB2 RAF1 ATR ATP6V1F AKT3 PMC4552335__F6 Proposed pathways through which ethanol administration elicits alterations in cytokine gene expression CD14 HMGB1 TLR4 PMC9301130__F2 Effect of Lithocholic Acid on the Gut-Liver Axis TH STAT1 NR1i1 STAT4 FGF19 PMC6761006__F1 Glucose metabolism via hexosamine biosynthesis pathway links amino acid, fatty acid and nucleotide metabolisms to regulate cell physiology and pathology via protein O-GlcNAcylation OGA OGT PMC7040003__F5 Differential expressed genes in the hormone-mediated ovarian maturation pathways in the polychaete-fed group GNRHR CDC20 ATG12 APC HEL-S-99n PMC8107278__F1 Using Biosensors to Study Protein–Protein Interaction in the Hippo Pathway MOB2 LATS1 PMC8750061__F5 Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients HEL-S-102 MID1 PMC9606346__F7 Combined analysis of the transcriptome and proteome of Eucommia ulmoides Oliv. (Duzhong) in response to Fusarium oxysporum ELF2 ATF4 BCL2 PMC10856016__F2 Phosphatidylinositol 3-kinase (PI3K) protein kinase B (AKT)/mammalian target of rapamycin (mTOR), PI3K/AKT/mTOR, and mitogen-activated protein kinase (MAPK) signaling pathway activation in gastric cancer (GC) BAD ERBB3 GC EGFR PIK3CA EIF4E MTOR FOXO1 FGFR2 BAX PMC5652672__F3 Somatic mutations in salivary duct carcinoma and potential therapeutic targets ERBB2 PIK3CA PTEN MTOR PMC5652672__F2 Somatic mutations in salivary duct carcinoma and potential therapeutic targets PTEN PMC6489558__F7 Hypothesis: after surgery, PTFs can stimulate surrounding hepatocytes to transform into a malignant phenotype, leading to hepatocarcinogenesis and tumor recurrence IL6 IL6R STAT3 PMC9243434__F1 Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development MTOR BDNF XBP1 PMC5726598__F8 PIK3CA cellular signaling pathway TSC2 TSC1 EGFR PTEN MTOR PMC9011221__F1 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review FER GPX4 STEAP3 HEL-S-64p IPP SLC38A1 GLS PMC5007815__F7 MAPK/MSK1/Histone H3 pathway on target gene transcription EGR1 GRB2 ID1 PMC3847587__F5 Significantly affected canonical pathway “Interferon signaling”, as determined by IPA™ analysis IRF9 TYK2 JAK1 IRF-1 PSMB8 IFNG BAX PMC7068598__F2 Emerging signaling pathways in CSCs IGF2BP3 EGFR IL33 MYC UNK SMO MTOR SIRT1 STAT3 PMC4489702__F1 miRNAs as biological and clinical determinants in colorectal cancer MACC1 CD151 PMC8106640__F6 PLPPR1 modulates RhoA-ROCK pathway PLPPR1 ARHA LPA PMC4090290__F1 Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process EGF COX2 EGFR MTOR TGFA STAT3 PMC5458189__F7 Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head GSK3B MTOR PMC10224166__F3 Anti-inflammatory effect and mechanism of atractylenolide I and III TLR4 FPR1 MYD88 STAT3 PMC3157425__F4 Apoptosis Induced by Piroxicam plus Cisplatin Combined Treatment Is Triggered by p21 in Mesothelioma LGALS3BP FOXM1 CDKN3 PMC10224166__F4 Anti-cancer effects and mechanism of atractylenolide I, II, and III BAD TLR4 MEI1 CDK2 MYD88 CDC2 MTOR NQO1 STAT3 BAX PMC4823096__F7 Novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells CIT PADI4 SOX4 PMC7671546__F8 G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor B2 in the rat hypothalamic paraventricular nucleus TSHB TRH STAT3 GATA2 PMC10138955__F5 Comparative Genomic Analysis of a Methylorubrum rhodesianum MB200 Isolated from Biogas Digesters Provided New Insights into the Carbon Metabolism of Methylotrophic Bacteria HEL-S-11 ELL MAL PMC7764203__F5 Metabolic pathways involved in lactate-based or ethanol-based chain elongation and production of acetate, n-butyrate, iso-butyrate, and n-caproate as predicted from the genome annotation of strains BL-3, BL-4, and BL-6 ETFB ADA ETFA PMC11355043__F1 Current model of the blood coagulation cascade, depicting NOACs’ mechanism of action TFPI PLG APC PMC7039088__F1 KEGG pathway map of the JAK-STAT signaling pathway obtained from the KEGG website GFAP MCL1 MTOR PMC5517452__F7 A putative signaling pathway of parkin expression induced by MIDN NGF PARK2 MIDN ATF4 PMC4949713__F3 WNT/B‐catenin signalling pathway APC GSK3B PMC7784988__F6 Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration EGF TNC EGFR PMC8130321__F5 Signature RNAS and related regulatory roles in type 1 diabetes mellitus based on competing endogenous RNA regulatory network analysis EPOR EREG F2R CS PIP4K2A GAST PWP2 CD2 PPP2R5C RAB27B HEL-S-93 ISCA2 INPP4A PMC4992754__F1 Sonic hedgehog (SHH) signaling pathway FOXM1 PTCH1 MYC CCND1 BCL2 SMO CCND2 PMC10473922__F9 Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NFKB pathway SIRT1 CD36 PMC8742202__F5 SMAD4 contributes to chondrocyte and osteocyte development PTH1R IHH RUNX2 LRP5 SMAD4 LRP6 FZD4 PTHLH SMAD1 SOX9 PMC10906782__F8 Different biological activities of DCV-derived soluble CPE and sEV-CPE BCL2 HTR1E PMC9121642__F2 Compound Kushen injection inhibits EMT of gastric cancer cells via the PI3K/AKT pathway CHUK MAP2 NR3A2 ACACA MYC ACHE MTOR POR PLAT NUF2 IL18 PKIA APP JUN MVP HK2 SELE BAX CXCL10 VEGFA CXCL2 HPSE HEL-S-130P MPG CYP3A4 PPARG PCNA PMC2716751__F2 The concept of angiotensin II-growth factor cross-talk in ureteric bud morphogenesis PAX2 WNT9B EGFR SPRY1 ROBO2 SLIT2 FOXC2 FOXD1 BMP4 FOXC1 FGF10 GDNF FGF7 PMC5516298__F1 FAM13A regulates the CPT1A–FAO pathway in chronic obstructive pulmonary disease (COPD) CPT1A FAM13A CPT2 HEL-S-5 PMC7526732__F4 Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women GNS CELA1 BCAM IGSF8 CELA2A POSTN WFIKKN2 PRKCSH AGR3 PEX14 IGFALS CYP3A4 CST6 F11 EFNB3 PMC9266892__F1 Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus APC GSK3B ARHA PMC7158706__F4 Upregulation of interferon signaling pathways IFIT3 IRF9 GAS1 IFNG HEL-S-162eP PIAS1 TYK2 JAK1 IFI35 IRF-1 PSMB8 SOCS1 BAX PMC9220294__F8 Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration HMGB1 GP9 TLR4 MYD88 PMC8671294__F1 Purinergic Signaling in the Regulation of Gout Flare and Resolution NLRP3 PIR MYD88 PMC4138046__F1 Multi-Level Kinetic Model Explaining Diverse Roles of Isozymes in Prokaryotes GCA HEL107 HPR PMC6978517__F7 TGFB2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells DGAT1 SMAD2 ADFP ACSL1 HEL113 CDH2 CD36 PMC8226215__F1 Assembling Disease Networks From Causal Interaction Resources EGF EGFR GRB2 MAPK1 PMC8107841__F6 Investigation of the association between imbalance of the intestinal flora and infantile spasms: a pilot case-control study LIPT2 LIPM PMC8560834__F8 Incorporating Transcriptomic-Metabolomic analysis reveal the effect of ultrasound on ethanol production in Saccharomyces Cerevisiae PDC MDH2 PMC8254453__F6 Circulating mtDNA-mediated acute lung injury during sepsis due to STING-dependent autophagy dysfunction TBK1 CGAS TNF PMC3539261__F2 Initiation of the inflammatory response to monosodium urate crystals (MSU) by the innate immune system NLRP3 IRAK4 IL1B PMC9266554__F0 3-keto-DON, but Not 3-epi-DON, Retains the in Planta Toxicological Potential after the Enzymatic Biotransformation of Deoxynivalenol BAD PALB2 MALL BLM CAST SSB ATM HEL-S-11 BRCA2 RAD52 PYY REST CAD RAD51B RAD51C PMC3547110__F3 Amplifying phase BTK BASH GAB2 TEC TRAF6 PLCG2 PMC5076476__F2 Pathogenic viruses target RLR regulation for immune evasion TBK1 PTMS TRIM25 DKFZp686F0183 MAVS PMC5573165__F1 The polyamine-hypusine pathway SRM EIF5A MYC DOHH SMO AMD1 DHPS SMS PMC6321707__F1 Putative Celangulin V biosynthetic pathway in C PMVK MVD MVK IDI1 IPP PMC7797476__F4 CILP function and regulation in NP cells by TGFB and IGF-1 CILP IGF1 SMAD2 IVD PMC8786143__F1 Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia HEL-S-62p C4B_2 VTN FH CRP C4A CFHR1 PMC3077819__F2 Widespread extracellular matrix (ECM) pathway silencing by DNA hypermethylation in colon cancer SPARC HEL-S-62p FBN2 HAPLN1 PLG NRCAM EVL MMP3 LAMA1 CD109 RET VTN TIMP3 NTNG1 GPNMB PMC3217183__F5 Signaling components of the RAS/MAPK pathway found to harbor activating mutations in various types of nevi and melanoma GNA11 BRAF PMC4418726__F3 RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem CAD PMC7999169__F6 mRNA-lncRNA co-expression network of the blue module EREG HIVEP2 AREG ATF3 CXCL2 TNFSF13 TRPS1 ATAD2 IFITM1 SPRY2 HES1 ISG15 GBP1 FADS2 TNFSF10 BEST3 LMO2 ADM PMC9277795__F8 circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3 AGO2 ALDH1A3 MTOR PMC3607621__F1 Dark face of AMPK as an essential tumor promoter ME1 HEL-S-26 ACLY CAMKK2 PMC3336066__F2 Double-strand break repair in mammalian cells ATM BLM ATRIP RAD52 RAD51 ATR DNA2 BRCA1 PMC2805706__F3 Brain foods: the effects of nutrients on brain function IGF1 MTOR BDNF PMC11667780__F4 mTORis reduce the number and function of Tregs via multiple mechanisms to inhibit tumor progression TSC2 TSC1 RHEB FOXP3 PMC2842986__F2 General synthetic route to the racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues (1a–e, g, i–k) is shown in RET WAS PMC2984612__F1 Cellular FLICE-inhibitory protein: an attractive therapeutic target? CAD FADD PMC4707216__F4 Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor HGF MMP2 MMP9 SRC PMC5128915__F2 THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer’s Disease CASP3 TSC2 CCIN PERP ATM STS CDK2 MYC MDM2 PTEN ATR PMC5166507__F1 Model for the cycling of ULK1 protein levels, which modulates the oscillatory mode of the autophagy response during prolonged starvation ULK1 MTOR PMC11667780__F3 Mechanisms underlying mTOR regulation in macrophage differentiation TSC2 TSC1 DEPTOR PMC7972846__F7 Effect of ECT on MAPK, AhR, and NFKB signaling pathways in CS-induced lung injury in mice IL16 CS AHR PMC3008185__F1 Two-loop model of iADE TBK1 TH STAT1 ISG15 STAT2 TRAF3 JAK1 STAT3 PMC11667780__F2 mTORis inhibit tumor metastasis to the lungs by suppressing EMT, tumor proliferation, and angiogenesis, whereas CNIs exert the opposite effect EPCAM HIF1A DEPTOR MLST8 PMC8146403__F1 Transport Proteins Enabling Plant Photorespiratory Metabolism SHMT1 PXN PMC5954140__F7 Gene regulation of ESRRG and Wnt signaling LEF1 CCND1 NR3B3 TCF4 PMC3089562__F7 Proposed model of how endocardial Jarid2 expression regulates myocardial development ERBB4 ERBB2 NOTCH1 CCND1 NRG1 JARID2 PMC9393759__F2 Circulating inflammatory cells in patients with metastatic breast cancer: Implications for treatment SIRPA CD47 CCR2 TLR7 FAP CD40 CSF1 PMC6274312__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules NRF RSAD2 PLK3 HDAC10 CD44 IFNGR2 TSLP PI3 TMEM97 MAPK12 ING5 SEC31A NFKB1 RELA ECSIT CYP1A1 SESN1 H2AX IL20 PMC11825815__F2 Macrophages in the progression of CP to PC: M2 macrophages interact with PSCs and contribute to the fibrotic process in the pancreas EGF EGFR TNF STAT3 PMC5119517__F1 The PI3K/mTOR signaling pathway TSC2 TSC1 PTEN RHEB PMC3875464__F3 PKG regulation of TRPC current and signaling HEL-S-62p TRPC1 RGS4 C6 RGS2 PMC11953522__F2 String pathway analysis of the significant genes with k means clustering → Red: apoptosis network (Bcl-2 family protein complex), yellow: Aspartyl transferase activity, Green: S100 protein pathway (1 S100A12 BCL2L1 S100A9 SH2B2 BCL2L11 BMF BCL2L2 CBL BIK PMAIP1 S100A8 GRB2 CLEC6A MCL1 CBLC HRK PMC4286392__F9 Notch and Eph / ephrin signaling pathways of non-myelinating oligodendrocytes relative to corresponding ones of their myelinating counterpart RAB14 SULF2 ASCL1 PLK4 PELI1 RET SUMF1 HEY2 AGA KALRN SMARCD3 CXCR4 ASNS NOTCH1 GTF2F2 CXCL12 GTF2B PMC5579652__F1 MYD88-mediated TLR4 signaling pathway results in the production of pro-inflammatory cytokines CD14 TLR4 IRAK2 IRAK4 MYD88 TIRAP PMC8943949__F7 Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells ELF2 CASP3 MMP2 MMP9 CCND1 CDK4 CDH2 PMC4665974__F4 Overexpression of Human Fatty Acid Transport Protein 2/Very Long Chain Acyl-CoA Synthetase 1 (FATP2/Acsvl1) Reveals Distinct Patterns of Trafficking of Exogenous Fatty Acids PC PMC8160449__F1 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection ULK1 ATG12 ATG3 ATG101 ULK2 ATG14 DKFZp686F0183 NBR1 PMC6412963__F1 Overview of cholesterol trafficking in enterocytes ABCG8 ABCG5 LDLR NPC1L1 ABCA1 PMC6808435__F6 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida PMC4590592__F8 Schematic view of the signaling pathways involved in healthy and CMML monocytes during CSF1-induced differentiation PLCB3 ULK1 P2RY6 PRKAA1 PLCG2 CSF1 CAMKK2 PMC7075910__F7 Protein interactions for ECM and summary of regulators SPARC CDH11 FBN1 CCL7 COL21A1 CCL2 TSHZ2 OSMR CFI HOXB2 CHPF2 FLT1 TIMP3 ERP27 CHRM2 TGFBR3 SP1 NTRK2 ST6GAL2 RELN BMP6 P4HA2 MASP1 KIF26B CD82 SRPX2 IGFBP7 SORCS1 TSLP PTX3 CD69 DPP10 IGF1 BMP10 PCDH17 KCNE4 HTR2B TF ENTPD3 ACVRL1 HGF COPZ2 COL3A1 ADAM12 TGFBR2 SLC5A7 ROBO4 SLIT3 COL1A1 CNR1 CEBPD GBP1 COL1A2 CD55 P4HA3 MCHR1 CHPF DIPLA1 HAND2 JUN ASIC2 SELE TFPI TBX2 PBX1 HEL111 RELA IL33 IL6ST LTBR COL4A2 TGFBI COL4A1 PMC8160449__F2 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection ACE2 NBR1 TMPRSS2 PMC9184561__F7 Mechanism of sorafenib-inhibiting inflammation induced by LPS LYN LBP TRAF6 IL6 PMC10149254__F5 Chemical composition of pigeon crop milk and factors affecting its production: a review SOCS3 STAT5B PRL PMC7097628__F3 Rewiring cellular networks by members of the Flaviviridae family STAT1 ATG16L1 ATG12 STAT2 ATF4 EIF2A DDX3X OSBP XBP1 HMGCR FASN STAT3 PMC3427795__F1 Interplay between FOXO, TOR, and Akt TSC2 TSC1 IGF1 SESN3 F3 PTEN EIF4E RHEB AKT3 PMC7068675__F5 Candidate drug repurposing based on dysregulated lnc-FFLs associated with GDM PIK3R1 BAD SLC16A10 EPO FOS ATP1B1 NR3C1 NRAS MYC ESRRA PFKFB2 CCND1 NR1A2 PMC6367546__F8 Schematic illustrating that CD9/ADAM17 axis plays a key role in keratinocyte migration via activation of EGFR/ERK signaling pathway EGF CD9 EGFR HBEGF ADAM17 PMC4621978__F9 D receptor‐mediated ERK1/2 activation via the PKCD/EGFR/B‐arrestin2 signalling pathway in response to specific agonist stimulation EGFR SRC HBEGF PMC2808051__F1 Summary of the insulin/IGF signaling pathway, using the terminology for mammalian systems ATM OGT PTEN MTOR BAX PMC3206266__F3 Androgen biosynthesis in the prostate HSD3B1 CYP11A1 AKR1C1 AKR1C2 CYP17A1 HSD17B6 PMC3281420__F1 Schematic overview of the multifunctional roles of c-FLIP in the TRAIL-triggered apoptosis pathway as well as activating various anti-apoptotic and cell survival signaling pathways TRAF1 TRAF2 FADD PMC2808051__F6 Mammalian target of rapamycin (mTOR) activation pathway EEF2K EEF2 GSK3B PTEN MTOR EIF4B RHEB PMC8198874__F3 Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis PC B4GALNT1 VILL CERK SMS B3GALT4 PMC3756396__F1 Simplified scheme of the possible involvement of cAMP/PKA pathway in cancer MDM2 SHH BCL2 PMC7183669__F9 miR-135b-regulation of JADE-1 inhibited the growth of cancer stem cells and tumors in PC via the AKT/mTOR pathway SOX2 MTOR PMC4867329__F2 Molecular mechanisms involved in glucosensing in the gastrointestinal tract TAS1R3 GIP TAS1R2 PMC7289296__F4 1A, 25-dihydroxyvitamin D3 promotes the translocation of Beta-catenin from the nucleus to the plasma membrane, and competes with T-cell transcription factor 4 (TCF4) for Beta-catenin binding NR1i1 PMC4737482__F1 Network mapping of genes with >5-fold expression change using IPA DCN E2F4 BCL2A1 NAB2 CXCL10 BIK RELA NEK2 ETV4 ENG PMC8348889__F1 SARS-CoV-2 and Acute Cerebrovascular Events: An Overview TFPI PLG VWF ACE2 TF PMC6604619__F10 Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor CYP27A1 CYP8B1 ACSL1 NR1C1 PMC5602287__F1 Summary of iAs effects on regulators of G1/(S)phase CDK2 E2F2 CCNE2 PMC8102306__F1 Intrinsic drivers of metabolic pathways TSC2 TSC1 MYC GRB2 ENO1 PTEN RHEB HMGCR PMC5285325__F3 Nuclear Dynamics of Heterochromatin Repair PML GC SMC6 RAD52 SMC5 PMC5499621__F10 The scheme for target of 4-O-Methylhonokiol on the TGFB pathway SMAD2 SMAD4 NOX4 SP1 PMC7146986__F9 Mechanism investigation of miR-195 in different stroke mediators, with a particular emphasis on the KLF5/ JNK axis SEMA3A CX3CR1 KLF5 CDC42 BAX PMC5085216__F8 Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification GHB3 FST VHL RAD51 BRCA1 PMC8450353__F7 Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19? MAPKAPK2 IL6 MYD88 TNF ACE2 TLR3 ADAM17 TMPRSS2 PMC6470667__F1 IL-1, IL-36, IL-37, and IL-38 receptors and intracellular signaling IRAK1 IL36A IL36B TRAF6 IL1R1 IL1RAPL1 IRAK4 MYD88 IL1B PMC8194077__F1 Therapeutic Targeting of Notch Signaling: From Cancer to Inflammatory Disorders DLL4 JAG2 PMC4024417__F1 Crosstalk between TGFB signaling and the renin-angiotensin system in fibrosis SMAD2 SMAD4 ACE2 TF PMC2978721__F8 Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells DBI FACL4 PBR HEL-S-5 PMC6670035__F6 Proposed role of TGFB1 in HASM cell contractile responses in asthma PDE4D AHR SMAD2 SMAD4 ARHA PMC9695027__F3 NTRK Gene Fusions in Solid Tumors and TRK Inhibitors: A Systematic Review of Case Reports and Case Series GRB2 MTOR PMC6020112__F2 Mechanisms involved in osteocyte mechanotransduction LRP5 LRP6 PMC5815915__F8 Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis BAD GCLC BCL2 NOX4 PMC5867005__F1 UPR signalling pathway SP2 ATF4 EIF2A SP1 PMC7066582__F3 Retinoid signaling pathways leading to lung cancer stem cell (CSC) differentiation and cell cycle arrest RARA RARB MUC4 EGFR FZD2 CCND1 GATA6 PMC3995826__F2 Pathways for (A) Maturity Onset Diabetes of the Young (hsa04950), (B) type 2 diabetes (hsa04930), and (C) Notch signaling pathway (hsa04330); adapted from Kanehisa, et al CCK PRKCZ MAML3 MAML2 INS LFNG MFNG DLL3 MTOR INSR MAFA PMC7457384__F1 Source of IL-33 and the IL-33/ST2 signaling pathway IL33 MYD88 PMC6555088__F3 GSK-3 signalling in heart HEL-S-28 SMAD2 APC MYC SMAD6 SMAD4 ARHA PMC4535771__F1 Using DeDaL for visualizing Fanconi pathway in breast cancer BLM PMC10949534__F11 Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression PIK3R1 EGFR SRC MAPK1 STAT3 PMC10949534__F10 KEGG pathway analysis: (A) PI3K-AKT signaling pathway and (B) MAPK signaling pathway TH MYB BAD CD37 TRADD FLNA ENG PTEN MTOR TSC2 NLK MAX APP SYK MEF2C RBL2 CD19 PMC6861014__F7 Model depicting the regulation of the host cellular response to systemic LM infection by C5aR1 and C5aR2 C5AR1 C5AR2 DDX41 PMC3061251__F1 Viral infection triggers the IFNB signal transduction pathway of the host innate immune system, activating the antiviral state ELF2 STAT1 TANK STAT2 TYK2 IFNAR2 JAK1 IFNAR1 TLR3 PMC6340394__F4 Black-Box Illuminated: Signals and Signaling GNS F3 MYC NRARP SIN3A CDK6 NEDD4 PMC10239166__F1 Transcriptional regulation on effector T cells in the pathogenesis of psoriasis IL2RA IL6R FOXP3 PMC8750102__F8 Amino Acid Metabolism in Cancer Drug Resistance SLC7A11 GLS PMC6068465__F5 p53 signaling pathway CASP3 TSC2 SIAH1 PERP ATM MYC MDM2 PIGS PTEN ATR BAX PMC2637179__F2 Role of IRS-1 in insulin and IGF-1 signaling IGF1 CUL7 GRB2 MTOR IRS1 PMC8750102__F6 Amino Acid Metabolism in Cancer Drug Resistance CTH PSAT1 PHGDH PMC12152130__F4 Relationship between cuproptosis and autophagy ULK1 FDX1 ATP7B FES MTOR SLC31A1 DLAT FDXR PMC10377916__F2 Revisiting Estrogen for the Treatment of Endocrine-Resistant Breast Cancer: Novel Therapeutic Approaches CASP3 SRC TNF HMOX1 XBP1 CASP8 FADD STAT3 BAX PMC7835541__F3 Effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification IRF9 TNF GRAP PMC4687794__F7 Signalling pathways downstream of CCK‐8s in pancreatic beta cells BAD CCKAR PMC6556479__F1 MC4R signaling pathway plays a vital role in regulating appetite and energy balance BBS2 RAB23 BBS1 PROK2 AFF4 BBS9 POMC BBS7 NHLH2 BBS5 BBS4 LEPR SIM1 MAGEL2 NR1A2 BBS12 NTRK2 ALMS1 BBS10 MRAP2 PMCH RAI1 KSR2 LEP MC4R MC3R PCSK1 ARC SH2B1 GNAS BDNF PMC3387006__F8 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes CDKN2B CDKN1A SMAD2 TGFBR1 E2F5 TGFBR2 SMAD4 CDK4 CDC2 PMC3387006__F7 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes ROCK2 FST DCN ID4 TGFBR1 E2F5 TGFBR2 THBS1 LTBP1 PMC8945680__F1 NFKB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders? BCR RELA TRAF3 LTB RELB TRAF6 TNF MAP3K7IP1 TRAF2 PMC4052840__F2 Therapeutics in development that target survival pathways activated by LMP1 and LMP2a FYN SYK MTOR PMC3409438__F2 Broad receptor antagonism and attenuation of downstream signaling cascades mediated by decorin in tumor cells CDKN1A MMP2 TIMP3 MYC VEGFA THBS1 TNF IL12B PMC8073517__F1 Adaptor Protein Myeloid Differentiation 88 (MyD88) in Post-Subarachnoid Hemorrhage Inflammation: A Systematic Review TRAF6 IRF3 MYD88 TIRAP PMC4348149__F1 Signaling-mediated Regulation of MicroRNA Processing AGO2 DGCR8 SNIP1 EGFR TUT4 DROSHA DDX5 BRCA1 TUT7 XPO5 PMC12195072__F4 In the kidney and parathyroid glands, FGF23 signaling requires the presence of FGFR (fibroblast growth factor receptor) and the coreceptor klotho FGF23 FGF2 PTH FGFR4 PMC6371191__F5 Role of PAK signaling in response to inflammation, altered microbiota and hyperglycemia PAK1 TLR4 APC RELA GSK3B JUN PMC9260738__F1 Hypoxia-inducible factor-1A: A critical target for inhibiting the metastasis of hepatocellular carcinoma HIPK2 VHL HIF1A PMC12255092__F1 Cholesterol structure and synthesis DHCR7 DHCR24 HMGCR PMC12255092__F6 Therapies that target lipid metabolism ABCG1 ABCA1 APOE PMC7016950__F8 Schematic outline representing neuronal adiponectin signaling pathway in the brain upon consumption of HFD ADIPOR1 IL18 GFAP LPO SYP PMC7093169__F2 Molecular mechanisms driving renal fibrosis are wide-ranging and complex, among which signaling pathways are very important ADIPOR2 NOX4 APPL1 PMC9318993__F7 Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing TLR4 MYD88 FLII PMC6857536__F2 Role of Ras pathway proteins in exo-some biogenesis, cargo selection and release EGF EGFR GRB2 RHO RAC1 SP1 TF CDC42 PMC9513835__F7 Molecular Mechanisms of Spawning Habits for the Adaptive Radiation of Endemic East Asian Cyprinid Fishes CS A2M PFN2 ZP2 PMC3776053__F7 A model for mid-day contrast sensitivity regulation ADCY1 NPAS2 PMC4514180__F4 Signal transduction pathways drive cancer metastasis EGF IGF1R IGF1 GRB2 SHE HBEGF TGFA PMC6830116__F4 Signaling pathways involved in Epithelial-to-Mesenchymal Transition EGF SNAI1 HGF SMAD2 EGFR LATS1 RHO LATS2 HMGA2 SUFU SMO CDH2 STAT3 CDC42 PMC4514180__F2 Roadmap of peptide vaccine versus peptide mimic strategies TH NOG PMC3355967__F1 Schematic of exosome secretion in a cancer cell model RAB5A RAB27A RAB9A RAB27B RAB13 PMC7039994__F7 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation BRAF DUSP9 RASA2 MAP2K2 RRAS2 ADCY3 FGFR2 ADORA2A FGF10 GRB2 ADCY6 GNAS RAF1 SOS1 DUSP8 DUSP3 PMC4276927__F4 Three intracellular signaling pathways are shown schematically NF1 TSC2 TSC1 MAP2K1 MAP2 MAPK3 PIK3CA MTOR RHEB PMC11855151__F6 displays the chemokine signaling pathway with all top-ranking lncRNAs and their interaction with pathway genes BAD GRB2 SHE REST ARHA CRK PER3 PMC11855151__F5 Antigen processing and presentation pathway (KEGG: 04612) displaying DE gene expression between AU and EU and the influence of the top-ranking lncRNAs in the prostate CTSL CANX CTSS SLC8A1 HEL-S-99n TNF B2M IFNG TAPBP PMC5819365__F1 Fanconi Anemia Signaling and Cancer ATM FAP FANCM PMC11855151__F9 Antigen processing and presentation pathway (KEGG: 04612) displaying gene regulation of AF vs CANX LIPE F11 SNAP25 TNF INTS6 IFNG TAPBP PMC8867096__F2 Unraveling Muscle Impairment Associated With COVID-19 and the Role of 3D Culture in Its Investigation IGF1 CRP ACE2 PMC8379503__F8 Impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation NAMPT NMNAT1 NRF1 TFAM SIRT1 PMC4496188__F10 The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1 EGF PAK1 EGFR SRC RAC1 PMC6671870__F6 The role of IDO/kynurenine in cancer immunoediting IDO1 FOXP3 PMC7327075__F1 Interaction between ferroptosis and lipid metabolism in cancer GPX4 LPCAT3 FACL4 SLC7A11 GC HEL-S-64p ADA GLS2 SLC3A2 LPO PMC6671870__F5 Sirtuins and epigenetic regulation of immune cell functions SIRT2 SIRT7 TLR4 SIRT4 SIRT5 SIRT6 SIRT1 SIRT3 PMC7534081__F1 Simplified schematic representation of the synthesis and metabolism of vitamin D.7-dehydrocholesterol in the skin is converted to previtamin D3 by UV-B and then is thermally isomerized to vitamin D3 CYP2R1 CYP24A1 CYP27B1 PMC7718039__F3 Mitochondria-mediated regulated cell death RIPK1 HEL-S-11 RIPK3 PARP1 TNF FADD MLKL PMC5722548__F1 CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population SULT1A1 CYP1B1 HSD3B1 SULT1E1 HSD17B1 CYP1A1 CYP17A1 CYP1A2 UGT1A1 PMC7039994__F4 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation PPP2R2D CSNK1D WWC1 YAP1 HEL-S-1 GSK3B SNAI2 FZD4 LATS1 WWTR1 MOBKL1A TEAD2 PPP1CC RASSF1 WNT4 NF2 AXIN1 STK4 PPP2CA DVL2 APC2 PPP2R2A MYOG FRMD6 PMC8742449__F5 Induction and application of ferroptosis in cancer therapy IL10 GPX4 RAB27A SLC7A11 IFNGR2 DKFZp686F0183 IFNG STAT1 AGER SLC3A2 JAK1 ARG1 IFNGR1 TGFB1 STAT3 PMC3768199__F1 Schematic overview of hippocampal signaling pathways following sleep deprivation SIRT7 USP2 PRKAA2 KCNV1 CA3 RBM3 MTOR PRKAB1 PMC2405914__F4 Catenins: Keeping Cells from Getting Their Signals Crossed SHH RHO CDC42 PMC8051110__F10 Combination of RRM2 silencing and radiotherapy promotes the activation of cGAS/STING signaling pathway in LUAD cells CGAS RRM2 CXCL10 IRF3 CCL5 PMC5632571__F1 Transcriptional regulation of Th9 cell generation APC CD80 IRF4 GATA3 BATF PMC6044872__F2 Biosynthetic pathway of O-glycans DST ST3GAL1 ST6GALNAC2 ST6GALNAC1 PMC8669353__F3 DNA methylation profile of liver of mice conceived by in vitro fertilization PDE3B BAD SOCS3 PTEN MTOR CRK INSR CBL LIPE FYN VAMP2 STX4A GRB2 ACLY GRB10 PMC8533760__F1 ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer STAT1 DUSP5 PALLD DUSP9 DUSP2 SP1 KNS2 HEL-S-61 DUSP7 PMC8476258__F2 Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China LEP PRKAA2 NPY PRKAA1 PRKAG3 STAT3 PMC3786574__F2 Molecular mechanisms of T cell co-stimulation and co-inhibition BTLA CTLA4 RAC1 MTOR ICOS CDC42 PMC5520447__F8 The functions of miR-26a/b-Jagged/Notch axis in modulation of EMT and fibrosis SMAD2 SMAD4 PMC12210845__F6 Analysis of protein-protein interaction network of combined DEPs and DEPPs related to ABA signaling pathway under HS in nucleus (a) and in chloroplast (b) ADA TEC PMC8229348__F2 Description of the relationship in healthy longevity and aging-related disease: from gene to protein KL FGF23 FOXO3A MYC MTOR TG DKFZp686F0183 CYP7A1 PMC12183514__F1 Mechanism of estrogen improving brain function, regulating lipid metabolism and alleviating osteoporosis IGF1 TG BDNF PMC8099713__F2 Host innate immune sensing pathway targeted by coronavirus TBK1 NUP93 IRF7 IRF3 MYD88 MAVS IFIT1 PMC4447342__F2 Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFKB Signaling in Hepatocellular Carcinoma IRAK2 NFKBIZ HIF1A RBBP6 TRIP10 ORM1 CDK6 ZFP36 BCL10 WEE1 NMI IFNGR1 UBASH3B ZNF165 PLAUR FOS IRF9 BRCA1 ELF3 CDKN1A ZYX TNFRSF1A SMURF2 SHB CARD10 ARHGAP21 RND1 TNFRSF10A TNFAIP3 TGFB1 VASP SFN RELB RHPN2 PDLIM7 MAP2K3 CITED2 CEBPD PPARGC1A BIRC3 THBS1 ETS2 RHOB JUN NR1H4 UBE2D1 RNF43 SKIL SPRY4 KLF5 ASAP2 PELI1 SMURF1 ID1 GATA4 CBL BCL6 NFKBIA HNF4A PTPRH NFKB1 TNFSF10 MAP3K8 JAK1 TNFRSF10B CSF1 ZC3H12A PXN KDM6B PMC8099713__F1 Sensing of RNA virus invasion by RLRs and TLRs TBK1 TLR8 TLR7 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS PMC3263689__F2 VHL complex targets HIF-1A and HIF-2A for ubiquitin-mediated degradation EGFR VHL RBX1 TGFA PMC8099713__F3 Antagonizing IFN-mediated immune responses by coronavirus STAT1 ISG15 STAT2 IRF7 IRF9 EIF2A TYK2 IFNAR2 JAK1 IFNAR1 PMC3263689__F5 FLCN pathway TSC2 FLCN BAD FNIP2 FNIP1 PTEN PMC8224678__F1 Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis NLRP3 NAIP TLR7 TANK TLR9 TRAF6 TLR3 TIRAP PMC6722770__F3A Prebiotics: Mechanisms and Preventive Effects in Allergy CCL2 MTOR IL1B STAT3 PMC4631758__F3 Gene regulatory networks involved in photoreceptor development CRX NRL PTF1A FOXN4 NR2E3 RORB RXRG OTX2 VSX2 PMC11015775__F1 Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China IL10 TH HEL-S-171mP APC IL6 TGFA PMC9479353__F5 Genetic regulation of RNA splicing in human pancreatic islets RGS17 RPL18A RPL19 EIF3C GLP1R RPL8 GPSM1 EIF3E EIF3D ADRA2A EIF3M GNAI3 VSNL1 ADCY5 RPS12 PMC7371520__F2 Caspase-1-dependent and -independent pyroptosis RHO AIM2 IL1B GSDMD DFNA5 PMC9552028__F1 Organoids as a Model System for Studying Notch Signaling in Intestinal Epithelial Homeostasis and Intestinal Cancer ATOH1 ADAM10 HES1 PMC8709313__F2 TKI Era in Chronic Leukemias BTK BASH LYN SYK PLCG2 MTOR CD79B CD79A CD19 PMC8709313__F1 TKI Era in Chronic Leukemias BCR MDM2 GRB2 RAF1 JUN PMC7324530__F1 PI3K/Akt pathway in health (A), cancer (B) and AD brain (C) cells GSKIP PTEN IRS1 PMC8431328__F1 Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder AHR CYP1B1 CYP1A1 CYP1A2 PMC7441741__F3 Tumorigenic mechanism in somatotroph cells AIP GIPR GPR101 GHRHR GHRH PMC3648157__F7 Dysregulation of cellular networks in the presence of PAN RNA expression NEU1 P2RX7 TNFRSF6B PROC NOTCH3 NOD2 NLRP3 BCR NGFR FOSB FAT10 NT5E PHLDA2 PTGIR BAG3 IRF7 ATF3 CCL4 PBX1 DUSP5 CARD9 TNFRSF1B ULBP2 TREM1 ELF3 TNFRSF13B CDKN2B EGR2 NR4A3 TFF1 STAT4 CCL22 IL18R1 PMC5799368__F7 Model for the regulation of BMI1 on androgen receptor independently of PRC1 PRC1 MDM2 TMPRSS2 EED PMC3764819__F4 Enrichment of the Notch signaling pathway in glioma CSCs HES5 NOTCH4 RBPJ KAT2A CTBP1 JAG2 DTX3 NOTCH1 NOTCH3 DVL3 ADAM17 STAT3 PMC7922135__F8 Hippo signaling pathway in OC (A) The main genes involved in Hippo signaling as regards OC and the associated miRNAs BBC3 TEF TP73 LATS1 LATS2 PMC3957914__F5 IFN-Beta-mediated regulation of PI3K/Akt/mTOR signaling and pharmacological agents active in this pathway TSC2 TSC1 TYK2 IFNAR2 JAK1 MTOR IFNAR1 IRS1 RHEB MLST8 PMC4302648__F4 Schematic plot of lncRNAs expressed in NSCLCs and their functions MYC TCF7L2 CDH2 NKD2 PMC6330346__F3 Rapamycin inhibits the de-differentiation of vascular smooth muscle cells FGFR1 FRS2 MTOR IL1B PMC8832753__F2 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages BAD GSK3B RELB TRAF3 PLCG2 PTEN BTK PI3 BCL10 BASH SYK TRAF2 CD19 PMC10770335__F3 Regulation mechanisms of KCC2 in mature neurons PLCG1 SMAD2 OSR1 BDNF PMC8832753__F1 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages PC PREB GC PMC11001198__F6 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue ERFE SLC48A1 EGF CIAO2B EPO HAMP CREB3L3 FES SMAD4 HFE TFRC IL6 HMOX1 HP CD163 MMS19 SLC40A1 MCOLN1 CP TF STAT3 PMC11001198__F5 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue ERFE SLC48A1 EGF EPO HAMP EGFR SMAD4 HFE TFRC IL6 HMOX1 HP GDF15 CD163 SLC40A1 MCOLN1 CP TF PMC6096230__F1 NOTCH signaling and graft-versus-host disease JAG2 NOTCH1 HES1 PMC10308667__F2 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis APC GSK3B DKK1 NKD1 PMC10308667__F1 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis APC GSK3B ARHA ROR2 RAC1 PMC6096230__F2 Notch signaling in mesenchymal stem cells JAG2 NOTCH1 HES1 FOXP3 PMC10308667__F3 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis WNT3A CDK14 APC WNT1 GSK3B DKK2 BCL9 SOX4 HMGA1 PMC8028134__F6 Pathway of flavonoid biosynthesis in the leaves of C F2 F3 PMC4077930__F3 mTORC2 in the center of cancer metabolic reprogramming RPIA PFKP HEL-S-133P HK2 GLS PMC3070553__F11 Signaling modules identified by correlational analysis of end points MARCKS BAD ERBB2 SMAD2 EGFR GSK3B GSK3A SRC PTEN STAT3 PMC7949100__F1 Central role of AR signaling in prostate cancer and targets in CRPC MED1 CYP17A1 CDK7 PMC5794831__F1 KEGG NFKB Signalling Network with dysregulated mRNAs highlighted and their associated miRNAs included NGF TRADD DAO TRAF3 TRAF6 COX2 BTK TLR4 BCR ATM BASH IL1B CD14 TRIM2 LTB RIGI CNTF LTA LBP LYN SYK TRAF2 LTBR LAT TIRAP PMC10121351__F8 Schematic of the molecular mechanism underlying UA anticancer activity in NSCLC cells EGF SOX2 EGFR ABCG2 STAT3 PMC4124246__F1 Signaling pathway induced by malarial ligand during liver-stage infection TBK1 IRF7 IRF3 MYD88 ATR MAVS IFNG PMC9654982__F1 Advancements on the Multifaceted Roles of Sphingolipids in Hematological Malignancies CER1 CERK SMS HEL-S-5 PMC4150215__F7 CREB-dependent cell cycle factor expression signalling network in GBM tumour cells CCNB1 CCND1 PCNA PMC10369979__F1 An oligonucleotide-based cGAS agonist for cancer immunotherapy CGAS NPS IRF3 PMC2879143__F4 Signaling cluster and integrin signaling NCL REN EGFR SKI TNF PMC4646463__F1 Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling HHIP EGF SUFU AREG PTCH1 EGFR SMO RPS6 MTOR PMC5492466__F3 Transcriptional changes of genes involved in basic metabolism in Bgt during asexual development on Chancellor XK CS COQ4 HEL107 PMC6693483__F2 Basic schematic representation of the cAMP-PKA pathway (green) and three MAPK pathways in Candida albicans which are important for morphogenesis, adaptation to stress and survival TF CDC42 PMC7222375__F3 Main cell signaling pathway involved in red cell homeostasis LYN SYK PMC4568928__F1 Proposed model for multiple-target inhibitory action in TT cells RET BRAF GRB2 SRC PTEN MTOR PMC10304357__F1 Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME CGAS TRAF6 IRF3 PMC9490147__F5 DNA repair as a shared hallmark in cancer and ageing ATM BLM ATRIP XPC SMARCAL1 RAD51 XPA ATR MRE11A APTX PNKP DNA2 PMC8482189__F3 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas NOTCH2 CARD11 BCR TCL1A BIRC3 TRAF3 MAP3K14 CD40 KLF2 MYD88 TNFAIP3 PMC7412551__F3 K-bZIP inhibits antiviral innate immune signaling and anti-proliferative signaling TBK1 CGAS CDK2 IRF3 PMC8482189__F4 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas NOTCH2 BIRC3 TRAF3 NOTCH1 KLF2 MYD88 TNFAIP3 PMC1682015__F2 Example pathway structures based on Z-scores of reactions, which demonstrate the metabolomic response of the selected reactions in the reported case studies, namely, the effect of an altered redox metabolism and aerobic/anaerobic growth TH PCK1 CIT GAD1 PMC2879143__F3 Activation of apoptotic signaling via caspase 3 and gelsolin ROCK1 APC FNTA ACIN1 PMC6039341__F3 RAS signaling cascade and EMT: Growth factors including EGF, FGF, HGF, VEGF, PDGF, IGF act through RTKs and activate PI3K–AKT, RAS-RAF-MEK-ERK MAPK and SRC signaling cascade SPARC EGF PATJ ZEB2 GSK3B PALS1 SRC PTEN PMC5732092__F2 Interleukin (IL)-17RA/RC signaling pathways TRAF5 TRAF6 TRAF2 IL17RC PMC4538579__F1 BAFF-induced activation of NFKB signaling and increased expression of proinflammatory cytokines as procachectic mediators IL16 TRAF5 TRAF3 RELB TRAF6 TRAF2 PMC7606751__F1 Role of BCAA metabolism in cancer progression BCKDK PPM1K MEIS1 SRC LAT TET2 PMC9600986__F2 Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment MMP9 POR PMC3504641__F1 Schema of the cholesterol pathway SQLE EBP DHCR24 TM7SF2 CYP51A1 PMC5436279__F5 Several roles of scrapie responsive gene 1 (SCRG1) suggested in this study and our previous reports CD14 TLR4 MSC BST1 SCRG1 CCL22 PMC4215229__F6 A model of FGFR4-mediated metabolic regulations FGF21 FGF19 FGFR4 CYP7A1 PMC11967072__F5 miRNA-mRNA regulatory network analysis and screening of the hub miRNAs IGF1R CHUK BAD MAPK8 GSK3B CREB1 BCL2L1 PTEN RB1 MTOR STAT5B FBXW7 CDK6 CCND2 PRKCA BCR MDM2 MAPK1 SP1 RBL2 CD19 EGR1 SCARB1 FOXO3A FGF2 CD44 IRS1 FOXO1 RHEB TSC2 EP300 SYK BDNF SIRT1 PMC5041020__F1 Leptin and jak-stat in cancer EGF EGR1 HGF ERG MMP9 VEGFA MYC PTEN RB1 TNF MTOR GHRH STAT1 LEP IGF1 EP300 MMP2 CD2 TNFSF10 BCL2 TGFB1 STAT3 BAX PMC3822800__F5 Diagram represents the molecular cross-talk between TLR2 heterodimers with TLR6/TLR1 and GR through the participation of PI3K MYD88 TLR1 TIRAP PMC2829067__F1 Caspase-1 Activation via Rho GTPases: A Common Theme in Mucosal Infections? ARHA RAC1 AIM2 IL1B NOD2 CDC42 PMC6125368__F2 Scheme of possible mechanisms by which autoimmune diseases are mediated by IGF-IGFBP signaling pathways PTEN MTOR IRS1 PMC4177473__F1 S-adenosylmethionine is produced from methionine by methionine adenosyltransferase HEL-S-61p PMC9409318__F7 Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARG and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes ULK1 TLR5 PRR5 RHO EIF4E TLR1 RHEB TSC2 TLR8 TSC1 TLR4 APP ARG1 CP PMC3073847__F1 TGFB signaling pathway TGFB is secreted in a latent form and activation is mediated by several molecules including furin and emilin ACVRL1 EMILIN1 SMAD2 TGFBR1 MAP3K7 TGFBR2 SMAD4 ENG FURIN SMAD1 DKFZp781O1323 PMC7226514__F2 “Prion diseases pathway” from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database with genes significantly modulated in brain samples from ASD patients that have been color-coded from blue (downregulated) to red (upregulated) EGR1 NOM1 PMC8389414__F5 LM pathway analysis highlights upregulation of AA-derived LM in non-survivors patients GSTM4 LTB PTGES VIP PMC8389414__F2 LM pathway analysis identifies an upregulation in ALOX5 activity in patients with severe disease GSTM4 PTGES VIP PMC9681083__F9 Schematic for the plausible mechanisms by which PI3K pathway inhibition mediated the anti-leukemic activity of FD268 AML cells BAD MTOR BAX PMC4349374__F1 Molecular events in the autophagy pathway ATG12 ATG3 ATG10 DKFZp686F0183 PMC11091328__F1 Regulatory mechanisms of SIRT1 on ER stress and NFKB signaling pathways ATF4 XBP1 SIRT1 PMC8530467__F1 Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? TBK1 STAT1 NOD1 STAT2 IRF9 IRF3 ACE2 MAVS TMPRSS2 PMC4594309__F1 Neurogenic niches and Eph:ephrin signaling CCL1 CP EPHA4 PMC4674750__F3 Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs PDC F2 FBP1 TP63 ENO1 PFKP HEL-S-133P HK2 HEL-S-68p HEL-S-162eP PMC7269991__F1 SOCS family genes were re-analyzed by KEGG pathway enrichment PIM1 IRF9 GFAP MCL1 MTOR PMC3335938__F1 Key therapeutic targets in the PI3K/Akt and MAPK pathways together with pharmacological agents inhibiting members of these signaling cascades PI3 BAD WEE1 MDM2 CCND1 PTEN MTOR AKT3 PMC7910854__F8 Schematics of neural circuit involved in phototaxis behavior PDF TRPA1 PMC3727154__F1 Immunomodulatory functions of type I interferons IL10 IRF9 IFNGR2 IFNAR2 MTOR IFNAR1 IFNG TBX21 STAT4 TYK2 JAK1 IFNGR1 STAT3 PMC2697290__F1 Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart CLCA1 CFTR PMC4292735__F1 Insulin growth factor 1 (IGF-1) signaling pathway TSC2 RICTOR BAD TSC1 IGF1R IGF1 GSK3B GRB2 MTOR DEPTOR IRS1 PMC4943968__F5 KEGG pathway (pathways in cancer) analysis with predicated target genes from all selected differentially expressed miRNAs E2F4 SMAD2 SMAD4 ORC3 CDK7 CDC45 ORC2 CDC20 SMC3 CDK2 MDM2 ORC1L PCNA SKP2 MYT1 PMC9385303__F10 Network Pharmacology Analysis, Molecular Docking, and In Vitro Verification Reveal the Action Mechanism of Prunella vulgaris L. in Treating Breast Cancer MAX TRADD APP TNF PMC7884707__F4 Wnt/Beta-Catenin signaling pathway-mediated therapy resistance in CSCs SMOC2 APC GSK3B LRP5 CD44 LRP6 SOX8 ID1 BCL9 PMC7884707__F3 Hedgehog (Hh) signaling pathway-mediated therapy resistance in CSCs IGF1 SUFU GLI3 KIF3A SHH IL6 PMC3243341__F3 Conversion of major constituents in the stem cuticular wax biosynthetic pathway HEL-S-62p CS HEL-S-5 PMC7744569__F4 Summary of metabolic engineering performed to increase fatty alcohol production in S PEX10 ADH5 PMC7769624__F10 Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling TLR4 TRAF6 MYD88 PMC5063567__F2 The Kynurenine Pathway Is a Double-Edged Sword in Immune-Privileged Sites and in Cancer: Implications for Immunotherapy AHR TEF PTEN PMC12029365__F4 TME lactate signaling ALDH1A3 AREG GPR132 GRB2 MTOR ABCB1 HCAR1 PMC4943968__F4 KEGG pathway (pathways in cancer) analysis with predicated target genes from downregulated miRNAs E2F4 SMAD2 DBF4 ORC3 CDK7 CDC45 CDC6 CDK2 MDM2 ORC1L CDC2 RAD21 PCNA SKP2 MYT1 PMC4943968__F3 KEGG pathway (pathways in cancer) analysis with predicated target genes from upregulated miRNAs E2F4 PLK1 SMAD4 DBF4 ORC3 CDK7 CDC45 SMC3 CDK2 MDM2 ORC1L PCNA SKP2 MYT1 PMC8294037__F2 Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis LIF GC MDM2 TG PMC4382528__F2 Metabolic pathway of rotigotine UGT1A9 CYP2C19 CYP3A4 CYP1A1 UGT2B15 PMC5630306__F7 Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL IL5RA MBP LYN IL5 PMC3238353__F2 Crosstalk between UPR signalling pathways and lipogenesis APOB INSIG1 ATF4 EIF2A NR1C1 PMC7941261__F5 Skeletogenic cell gene regulatory network (GRN) ERG TEF FOXN2 HEL23 PMC3238353__F1 ER stress and activation of the UPR signalling pathways ELF2 ATF4 PMC10388482__F9 SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression VEGFC VEGFA VEGFB PMC3681689__F6 Working model for the roles of the mitochondrial chaperones Ssq1-Jac1 and the glutaredoxin Grx5 in Fe/S protein maturation in eukaryotes NFU1 PMC6123662__F2 Brown adipocyte glucose metabolism: a heated subject CS DGAT2 HEL-S-30 UCP1 PCK1 GYS1 TG AQP9 HMFN0839 GYS2 AQP3 PC AQP7 MPC1 ACSL1 ACD ADRB3 HK2 FASN GPD1 PMC3644409__F7 Proposed model showing molecular mechanisms of dysregulated immune pathways in diabetic renal tissues HLA-E BMP7 TRAF6 MIP TSLP IL6R CEBPB UCP2 HEL-S-162eP HLA-A GPX3 TLR4 TAP2 BCL10 SIGIRR HEL-S-64p IL4 CXCL14 SELE MSRA STAT3 PMC5369916__F4 Summary of detected genes associated with the MTX toxicity in RA patients in previous studies GGH SLC16A7 AMPD1 FPGS SLC46A1 RFC1 ABCC1 MTRR DHFR ADA TYMS CCND1 HEL-S-70p ABCG2 ABCC2 ABCB1 PMC2786873__F9 Model of amino acid starvation-induced AARE-dependent transcription in human cells ATF4 ATF2 EIF2A ATF3 RAC1 CDC42 PMC7157599__F2 An overview of intracellular signaling pathway regulation by the HECT E3 ubiquitin ligases HERC1 UBR5 SMURF2 MYC HUWE1 PTEN WWP1 HERC4 SMURF1 NEDD4 ITCH PMC8350904__EV4 Schematic depiction of the metabolic networks active during latent HIV‐1 infection in microglial cells PCK1 FBP1 ENO1 GCK PGAM4 HEL-S-87p HEL-S-32 HEL-S-68p HEL-S-162eP H6PD FH PKLR HEL-S-304 RPIA ACLY HEL107 SDHA LDHAL6A PMC7953519__F7 Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome MAP3K1 SOX9 PMC2719801__F3 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways PRKAA2 MAPK8 SOS2 MAP3K7 TBC1D4 PIK3R3 INSR RPS6KB1 SLC2A4 MAP3K2 MAP4K3 HEL-S-42 PTPN11 PIK3CA PMC2719801__F2 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways PIK3CD PIK3R1 SOCS3 MAPK8 PDPK1 INSR PRKCA MAPK12 PTPN11 RAPGEF1 PRKCQ EHD1 GYS1 EIF4E PFKL HEL-S-31 RHEB IKBKB MINK1 LIPE VAMP2 SLC2A4 MAPK4 PIK3CA RAF1 CBLC PMC7600158__F1 MicroRNA (miRNA)-mediated modulating response to gemcitabine NDRG2 NF2 APC LIF GSK3B SRC PTEN STAT3 PMC12237979__F2 Necroptotic pathways TLR4 TRADD RIPK3 TRAF2 FADD TLR3 ZBP1 MLKL PMC2517664__F2 A simplified diagram of the key type-1 cytokine/receptor interactions relevant for immunity against intracellular bacteria, derived from published gene knockout mouse studies IFNGR2 IFNGR1 IL12RB1 IFNG PMC6345051__F5 Visual representation of molecular interactions in the TSF flock BOC PARM1 DES PRELP NGB TEAD3 DCN CADM1 COL14A1 MDK LINGO1 P3H2 GRB14 RBM38 SLC22A17 FAM3B ISL2 NID1 NID2 OAF BANK1 SYNM COL4A2 TGFBI COL4A1 PMC3410677__F9 Schematic representation of potential interaction between the Rho GTPase signaling pathway, CTGF, and NMU in regulation of actomyosin-based contractile force and ECM protein profiles in TM cells NMU ARHA RHO PMC6345051__F4 Visual representation of molecular interactions in the HSF flock CXCL13 FCER2 FCMR CD22 LTB JCHAIN CCL19 CR2 CD79B CCL22 CD79A CD19 PMC3798767__F5 p53 regulated developmental pathways MAPKAPK2 NUMB APC GRB2 APP SMAD4 TPR SFRP1 MAP3K7IP1 WIF1 CRK PMC9097798__F1 Development of novel agents for the treatment of early estrogen receptor positive breast cancer EGF EGFR MTOR PMC2679052__F7 Diagram summarizing differences in expression of interaction genes enriched within the KEGG p53 signaling pathway, and possible interactions of corresponding proteins with the androgen receptor CDKN1A CCND1 PTEN PMC4298213__F1 Generalized central metabolic pathway adapted and modified from a previous study PC HEXA GOT2 TREH HEL-S-304 SDHD HEL-S-32 MDH2 PMC5359264__F3 ReactomeFIViz: from disease pathway to PPI network UBC E2F2 ERF SP1 TFDP1 E2F3 PMC7553876__F1 Hypothetical mechanism by which SARS-CoV-2 successfully evade the immune system while maintaining an inflammatory feedback loop ACE2 IL1B ADAM17 TMPRSS2 CCL3 PMC9546682__F7 Yangxin Tongmai Decoction in the Treatment of Coronary Heart Disease with Blood Stasis Syndrome Based on Network Pharmacology and Molecular Docking MYB BAD ASIP MYC GRB2 APP SYK PTEN GAL MTOR COMP PMC10931763__F8 “Component–gene–pathway” network PDE4D IGF1R EGFR BCL2L1 DRD1 ITGA4 RB1 DRD2 TRPV1 CSF1R FGFR1 NR1i1 IL2 NTRK2 JUN PLG PTGS2 NTRK1 MMP9 NR3C1 VEGFA S1PR1 ADRB2 HPSE NR1C1 CASP3 PIK3CA HTR2A PPARG HTR2B TERT STAT3 PMC9942259__F7 LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/B‑catenin pathway LAPTM5 MMP2 MMP9 CCND1 CDH2 FOXP3 PMC8105340__F9 Endovascular progenitors cell fate RBPJ PDGFRA PTCH1 CD34 SOX9 HES1 PMC8102455__F2 Fabry Disease: The Current Treatment Landscape GLB1 HEXA A4GALT GLA PMC4367559__F2 Mechanisms of resistance due to MET/HGF pathway and potential interventional strategies EGF HGF EGFR VEGFA PMC6162868__F1 Signaling pathways of high-risk HPV oncogenes MDM2 CCND1 CDK4 PMC4367559__F1 MET/HGF signaling and functional cross-talk with other pathways EGF BAD HGF ALK EGFR GRB2 VEGFA SHE SRC MTOR PMC8955100__F1 Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection LCK ZAP70 CD160 CD48 BTLA TIGIT LAG3 PMC11241432__F3 MyD88-independent signaling pathway IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TAB3 MAL PMC5693225__F6 RPL23 links oncogenic RAS signaling to p53-mediated tumor suppression MDM2 RPL23 MTOR PMC5779689__F2 Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells EIF4A1 HEL-S-99n EZR HSPD1 SGTA RPSA HEL-S-128m HEL-S-94n RANBP1 LAP3 ANXA2 HEL-S-44 RUVBL2 ANXA1 PA2G4 PROX2 ENO1 HEL-S-47e HEL-S-49 TCP1 RBBP7 HEL-S-100n HEL-S-93 PCNA GLUD1 PMC6154708__F5 Epigenetic mechanisms of nanotopography-guided osteogenic differentiation of mesenchymal stem cells via high-throughput transcriptome sequencing CD99 DYSF KLK4 CTRC HAL LAT2 SMAD2 MMP11 ALAS2 FSTL3 NLRP3 CGB8 PI3 AQP7 TRPM2 GNRH1 AQP1 AQP6 JPH2 CMYA5 PRSS16 MT1B TNLG2B TPSG1 MAP1LC3C IGF1 HRC TMEPAI DPT MEFV PMC5730046__F3 Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming ME1 HK3 PRKAA1 GCK SLC2A13 MDH2 HEL-S-68p HEL-S-162eP HEL-S-49 PC FH PKLR RPIA OGDH HEL107 RPE PGAM2 PMC6086774__F1 Lipid metabolism in tumor cells ACSL1 ACLY TG FASN CD36 HEL-S-5 PMC6029376__F7 Working model of the mechanistic interaction of miR-335-5p and CPNE1 in the control of the EGFR signaling pathway: miR-335-5p regulates CPNE1 expression via EGFR signaling in NSCLC EGF MMP9 CPNE1 CCND1 SRC CDH2 PMC7139634__F6 Most common target genes and mTOR pathway regulated by the differentially expressed exosomal miRNAs IGF1 PTEN EIF4EBP1 MTOR PXN PDPK1 INSR PMC7913176__F4 Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes OPRM1 TGFBR1 EGFR NR3C1 TOP2A RANBP9 DTL COPS5 CENPW MAEA APP GFER FABP5 RAF1 HEL-S-93 AXL PMC7465132__F2 Cell death receptor-associated signaling pathway TRADD CYLD TRAF2 FADD MLKL PMC7795579__F1 Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria MFN2 MAX MCU PMC7984080__F1 Brain death‐induced lung injury is complement dependent, with a primary role for the classical/lectin pathway C9 C7 C6 PMC3281591__F4 Mitochondrial-dependent apoptosis CASP9 BCL2 PMC6961632__F1 Unique Features of Nodules.(A) Nod factor activation of the CSSP FEN1 SST MNT DCT ERN2 TF PMC5653517__F1 Resistance to BRAF inhibitors can occur through stromal extracellular signals (blue) leading to ERK reactivation upstream of MEK (orange) or to enhanced survival signaling(green) NF1 IGF1R BRAF ERBB3 EGFR PMC8784536__F2 Immunomodulatory effects and mechanisms of distraction osteogenesis SMAD4 PMC7710763__F1 Interaction between gut microbiota, immune system and tryptophan metabolism in brain tumor development IL10 STAT1 IDO1 EGF SLC1A4 AHR SLC7A11 ATF4 IL2 IL6 IL1B PMC5390343__F6 Regulation of Fn expression in macrophages after S CD14 SRC TRAF6 MYD88 PMC2886982__F3 Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes LPL CIDEA HEL-S-31 PMC8584042__F2 Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface PIEZO1 SRC LATS1 RHO LATS2 PMC9485670__F2 Advances in the research of the mechanism of secondary resistance to imatinib in gastrointestinal stromal tumors IGF1R MDM2 PMC7679160__F8 PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion TBK1 PPM1G IRF3 MAVS PMC8037620__F1 Spectrum of changes in a senescent cell CSF3 CCL7 CCL5 CCL2 MTOR IFNG MMP3 CSF2 DIPLA1 IRF-1 SERPINB2 HMGB1 CCL8 IL1A MMP9 VEGFA CXCL2 PARP1 TNF GATA4 MMP12 VCAM1 NFKB1 CDK2 IGFBP4 IGFBP2 CSF1 INHBA PMC4217731__F7 Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice PPARGC1A CPT1A NR1C1 PMC6487791__F3 Therapeutic strategies targeting mutant p53 USP15 CDKN1A WEE1 ATM MDM2 CDC2 ATR BAX PMC6487791__F2 Representative working modes of mutant p53 GOF PIN1 SLC7A11 SMAD2 ARHA CDK4 TXN PMC5915168__F1 MIF signaling pathway and its role in tumorigenesis CD44 SRC CD74 PMC5514692__F7 Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption HEPH HMOX1 BACH1 PMC2840235__F1 Blockade of the VEGF pathway with mAbs PIGF VEGFC VEGFA VEGFB PMC12108901__F7 Comprehensive model of nitrogen and phosphorus interaction at different levels DAO IMP3 PMC5053787__F1 Complement cascade HEL-S-62p C4B_2 C1S PMC9658871__F8 Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D PLD2 POSTN HEL113 PMC4648367__F7 Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway targetgenes and promote cell migration ANKRD1 EGF ERBB4 EGFR NRG1 LATS1 LPA PMC7783759__F7 Cezanne deubiquitinated IGF-1R and regulated IGF-1R signaling pathways IGF1R IGF1 ATF2 IRS1 PMC9368778__F5 Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant TBK1 CGAS IRF3 LATS1 LATS2 PMC2807212__F3 TGFB superfamily and FGF signaling pathways FRS2 GRB2 SMAD6 SMAD4 PMC10255413__F2 Biosynthetic pathway of chlorophyll MGP CPOX POR PMC8536449__F9 GNG4 Promotes Tumor Progression in Colorectal Cancer PI3 BAD CELA1 MYC GAL PLEK MTOR CD19 PMC2807212__F2 Hh and Wnt signaling pathways SUFU APC PTCH1 SMO PMC8507869__F3 Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring BRAF ALK NTRK1 EGFR PTEN RB1 MTOR CCND2 CCNE1 RET CCND1 CDK4 AXL ROS1 PMC9268608__F11 Stereoselective Binding of Trans-(±)-Kusunokinin and Cis-(±)-Kusunokinin Isomers to CSF1R EGF COX2 CSF1R IL34 CDK2 EGFR CCND1 JAK3 AKR1B1 CSF1 STAT3 PMC3514894__F1 Interplay between Smoking-induced Genotoxicity and Altered Signaling in Pancreatic Carcinogenesis EGF CDH24 FOS GC MMP9 EGFR MYC BCL2 CDH2 PAH JUN STAT3 PMC5292191__F2 Extrinsic and intrinsic pathways of apoptosis FADD BAX PMC5292191__F1 TGFB signaling pathways SPARC GRB2 SHE SRC ARHA GIP RHO RAC1 PMC4572424__F2 Effect of purple corn anthocyanins (PCA) on CCN2 expression STAT1 SMAD4 CTGF STAT3 PMC4156078__F7 Schematic diagram depicting the proposed role of miR-130a in BMP-SMAD signaling and hepcidin regulation under iron-deficient conditions BMP6 SMAD4 SMAD1 DKFZp781O1323 PMC8123809__F1 Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology RUNX2 BMP2 BMP4 PMC9631428__F1 Research progress on microRNA in gout NLRP3 ZEB2 TRAF6 IRAK4 MYD88 EPHA2 PMC5684415__F1 Highest confidence network of genes significantly dysregulated by miR-7 KIF23 ATL1-beta FOXM1 SMAD6 AURKA CDCA8 NCEH1 KIF11 CDC20 RRM2 NCAPG CCNB2 CCNB1 TRIP13 PMC5824027__F3 Hippo Pathway in Cancer Stem Cell Biology APC VGLL4 SRC LATS1 RHO LATS2 PMC5078657__F2 Cancer pathway targets affected by curcumin EGR1 EGFR VEGFA MTOR PTCH1 CXCR4 CCNB1 SHH CCND1 CDC27 ERCC1 ABCG2 STAT3 BAX PMC3650722__F3 Network was generated using Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com) SORT1 PDGFD LIPA APOC3 PMC9587083__F7 Hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer HMMR ADAM2 VCAN HYAL2 CD44 HYAL3 HYAL4 HAS3 HAS2 IDUA GUSB WWOX PMC5824027__F1 Hippo Pathway in Cancer Stem Cell Biology AREG VGLL4 LATS1 DKK1 LATS2 PMC4660682__F5 Relative functions and pathways in DN EGF LEP CD9 HAMP LGALS3BP CRP KLK3 IL6ST CSF1 APOA2 TXN PMC5039640__F6 Unravelling molecular mechanisms from floral initiation to lipid biosynthesis in a promising biofuel tree species, Pongamia pinnata using transcriptome analysis LPA ACD HEL-S-5 PMC3193279__F1 VEGF Signaling Pathway within endothelial cells PIGF CSK FGF2 CRK FLT1 KDR FRS2 PTPN1 TIMP3 GRB2 ITGAV RAF1 SOS1 VEGFB PMC10367548__F8 The mechanism by purinergic receptor P2Y12 drives ConA-mediated autoimmune hepatitis through hexokinase 2-dependent glycolysis pathway HK2 IFNG PMC6889474__F3 mTOR Signaling Pathway TSC2 EEF2K TSC1 MCRS1 PTEN EIF4E EIF4B SGK1 RHEB PMC6729444__F7 p35/Cdk5 involvement in RasGRF2 signaling EGF RASGRF2 EGFR PMC5037594__F7 Signaling pathways in EGF-induced AREG mRNA expression EGF AREG EGFR PMC3722917__F3 Naive CD8+ T cells differentiate into cytotoxic T lymphocytes (CTLs) on exposure to antigens TH APC TRO PMC11040418__F2 Network pharmacological analysis of chondrocyte apoptosis modulation by RJNTF PIN1 RPA3 FLNA SMAD2 GSK3B MYC TRAF6 CCL2 HIF1A CUL7 MDM2 SRC SNW1 ILF3 HDAC2 MAPK1 EZH2 NOS2 IRF-1 HSPA4 MAP3K1 NCL TUBB BAG3 CXCL10 CAND1 HEL-S-310 RNF2 NEDD8 TNF CUL4A MCM5 MCM2 CDC5L VCAM1 CDK2 GRB2 CLTC U2AF2 VCP RPS3 TUB HEL-S-72p SIRT1 IKBKE HEL2 EGFR ITGA4 EWSR1 DKFZp686L0365 UBC PABPC1 RPS2 RPS27A APP EIF4A3 IL1B JUN SELE RPA1 PTGS2 NTRK1 VHL CXCL2 PARP1 IL6 RPS8 AURKA FUS PS1TP5BP1 HEL-S-102 NFKBIA EP300 NFKB1 COPS5 RELA RPL10 HEL-S-93 PXN PMC8209426__F10 An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure WEE1 ATM FOXM1 MYT1 PMC7584388__F5 Mechanisms underlying T cell ageing CGAS ZAP70 MTOR MAP3K7IP1 LAT GATA4 PMC8428233__F2 Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors STAT1 RUNX2 SMAD2 MYC SMAD4 JAK1 STAT3 BAX CD24 PMC7906381__F2 Pathway enrichment analysis of (a) DE-miRNAs and (b) DCGs KIT RALA MTOR PMC9593040__F2 Mitophagy in the aging nervous system PINK1 GABARAP PMC3337681__F7 Putative inhibitory pathway of inflammatory signaling events by CA TLR4 IRAK1 ATF2 SRC SYK PMC11939404__F9 Proposed mechanism of action of GAD037 BOC ACTN4 INSR PMC9025382__F6 RNA-Seq of Cyst Nematode Infestation of Potato (Solanum tuberosum L.): A Comparative Transcriptome Analysis of Resistant and Susceptible Cultivars MYB FER ERF PMC8340210__F2 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations FOXA1 PARP2 PMC11013310__F6 Our results are summarized in this diagram HGF IGF1 PCNA PMC2390572__F9 MCF10A Pathway 1 affected by TFIIS knockdown IFIT3 BAMBI SS18 MYC TNPO2 NPDC1 NKX2-8 PPP1R15A IL15 PERP TLE4 RBBP7 HMGN2 GPRC5A CTSW ARID4A PMC2390572__F8 Major pathways affected by TFIIS knockdown in MCF7 DKFZp667O1614 IRAK1 CFHR4 MYC RPL35 RPL27 FGFR3 SERPINB5 RPL18 CDKN2A BLZF1 NRP2 SMARCC2 HEL-S-32 CFI SMARCA4 RPL41 RPL21 RPL23 KITLG PLXNA3 BRD2 GTF2B RPS23 PMC5325772__F4 Summary of relationship between B-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway that upregulates aerobic glycosylation NCOR1 MEN1 PMC8303858__F4 Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2 REN APLN MMP9 VEGFA INS NPPB HIF1A IFNG EDN1 FGF23 MMP2 SLC2A4 ADAM10 FURIN ACE2 TMPRSS2 TGFBI PMC3765220__F4 Pathway Studio analysis of the differentially expressed proteins of extremely severe HFMD serum samples. Proteins identified in Table  were imported into PathwayAssist and an interaction map was created PML RPE65 FCN3 HEL-S-92n RDH5 BRCA1 ITIH2 HEL-S-2a A2M HP RBP4 KRT1 RDH11 PMC7349719__F2 GH/IGF on the Aging Mitochondria IGF1R CS IGF1 GHR BNIP3L BNIP3 PMC3046063__F7 Proposed working model and protein–protein interaction map ATG3 EGFR PTEN MTOR DKFZp686F0183 GNAI1 NBR1 WDFY3 PI3 MAP1B MAPK1 KIF15 UVRAG XRCC3 NDEL1 BAX DISC1 BAK1 PARP1 CENPE ATG10 INSC TSC2 GNAI3 BCL2 PMC5963164__F7 Prostate cancer pathway enriched in KEGG BAD FRK CDK2 MDM2 BCL2 PTEN MTOR HEL-S-22 PMC5963164__F8 ERK/MAPK signaling enriched in IPA BAD FYN MOS PC GRB2 ATF1 SRC DOCK1 EIF4E CRK PXN ARAF PMC7349719__F6 GH/IGF on the Aging Mitochondria BAD IGF1R IGF1 BIK BCL2 BMF HRK PMC12256062__F8 Antagonists of cGAS-STING pathway for liver diseases therapy TBK1 NLRP3 CGAS IRF3 XBP1 PMC6581679__F1 Canonical activation of HH-GLI signaling SUFU GLI3 GSK3B SMO PMC6409748__F2 TLR-7/-8 signaling in dendritic cells TLR7 IRF7 IRAK1 TRAF3 TRAF6 MYD88 PMC6581679__F3 Non-canonical activation of HH-GLI signaling by oncogenic pathways NUMB EGFR GSK3B MTOR DYRK2 DYRK1B SOX9 DYRK1A BRD4 PMC1087583__F5 The secretory pathway and UPR under different conditions VPS41 SEC63 PMC3502714__F3 Fibroblast growth factor 23: State of the field and future directions FGF23 FGFR4 FURIN GALNT3 PMC3502714__F2 Fibroblast growth factor 23: State of the field and future directions FGF23 FGFR1 PTH FURIN GALNT3 NHERF1 PMC9477627__F8 Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology TH MYB CAP2 MAX FLNA MYC GRB2 RAC1 SKI TNF PMC8340210__F1 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations PALB2 BRIP1 BARD1 SSB CDK12 PARP1 CHEK1 BRCA1 CHEK2 ATM BRCA2 FANCL ATR RAD51C PMC10530558__F6 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells HEL-S-5 PMC10530558__F2 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells MYC HEL-S-133P HK2 PMC10530558__F1 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells MYC HIF1A PMC6215910__F7 Model illustrating the potential pathway from pseudohypoxia-induced cilia loss to increased cell proliferation and dysregulation of tumorigenesis relevant cilia-mediated signaling pathways in PCCs FH VHL PMC2564980__F5 Genes with differential expression in the carcinoma and papillary adenocarcinoma tumors were assembled into distinct metabolic pathways EGFR APC GSK3B SMAD4 RHO FZD9 CCND2 FST PSEN1 GBP2 SRC THBS1 ATR LAMC1 SMAD1 INHBA TCF4 FZD8 CDC42 AKT3 PMC2564980__F7 Higher expression of genes involved in O-glycan synthesis in the carcinoma compared to the papillary adenocarcinoma tumors GALNT7 GALNT10 PMC8556325__F1 KRAS pathway and targeted preclinical and clinical agents EGFR GRB2 MTOR PMC6021495__F10 Working model proposed for the synergistic action of GH and insulin on IGF-I and -II expression in the carp liver GHR MTOR INSR PMC5795449__F4 IDO1-mediated Tryptophan Depletion IFNGR2 IFNGR1 IFNG PMC9576517__F2 Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies ELF2 TBK1 FOXA3 CCL2 MERTK HEL-S-7 TGFA CXCR6 FOXO1 PER1 FASN HEL-S-5 PMC9313121__F4 Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia SNAP25 PMC8944741__F7 Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases BACE1 LPO ACHE BCHE BDNF IL1B BAX PMC9377080__F2 Diverse functions of FAT1 in cancer progression: good, bad, or ugly? EGF YAP1 EGFR LRP5 NRG2 HBEGF LRP6 NRG1 MTOR IRS1 FAT1 PMC9052917__F7 Complement dysregulation is associated with severe COVID-19 illness CS CFH CRP PMC8108610__F1 Entry, egress and vertical transmission of SARS-CoV-2 ACE2 TMPRSS2 HEL-S-69p PMC4809647__F3 Highly heterogeneous, activated and short-lived regulatory T cells during chronic filarial infection IL10 CCL4 CTLA4 LAT ARAP2 PMC6761256__F10 Putative mechanism of necroptosis and relative inflammatory responses during the development of CCI NLRP3 HMGB1 TNFAIP3 IL1B MLKL PMC12112630__F17 Overexpression of miR-454-3p leads to the inhibition of STAT3 and ATG12, which are involved in molecular pathways promoting Chondrosarcoma cell proliferation and evasion of apoptotic and autophagic mechanisms ATG12 ATG10 DKFZp686F0183 STAT3 PMC9681860__F1 Copper homeostasis and cuproptosis in health and disease ATP7B COX17 SCO1 ATP7A ATOX1 HEL-S-44 COX11 SLC31A1 CCS PMC9681860__F2 Copper homeostasis and cuproptosis in health and disease FDX1 LIAS FES DLAT PMC2673236__F1 Schematic illustration of one-carbon metabolism pathway HEL-S-61p MTR MTRR PMC6681663__F1 Everolimus for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC) RICTOR PTEN MTOR ELF4 RHEB PMC6394863__F6 Fluid forces shape the embryonic heart: insights from zebrafish TRPV4 ERBB2 WNT9B NRG1 WWTR1 HEG1 PMC6934083__F1 Autophagy regulates the expression of HDAC proteins which in turn leads to altered transcription and enhanced tumor cell immunogenicity IDO1 EIF2A MTOR DKFZp686F0183 PMC10136927__F3 Targeting Wnt signaling pathway by the latest technologies ZNRF3 RNF43 APC LRP5 PTK7 FZD7 LRP6 GPR49 PMC11667779__F3 Adenosine signaling in TAMs ARG1 PMC3843886__F2 Schematic of common signalling pathways underlying activity-dependent and leptin-dependent synaptic plasticity GSK3B STAT3 PMC6850109__F1 Pathogenesis of antibody‐mediated rejection and potential therapeutic targets CD40 CP PMC7921060__F6 BMP/Hippo signaling modulating VEGFR pathway and angiogenic phenotype of endothelial cells BMP6 BMP2 AREG DLL4 SNAI2 PMC5059634__F3 Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes CS GAA PMC3967813__F2 IFNAlpha-2b signaling via JAK-STAT pathway, adapted from TYK2 IFNAR2 JAK1 CRKL PMC3151145__F1 Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling CD14 NPC1 TLR4 ACAT1 ABCG1 LDLR NPC2 HMGCR CD36 PMC8508945__F2 Translation Initiation Machinery as a Tumor Selective Target for Radiosensitization TSC2 TSC1 PTEN EIF4E PMC6657652__F6 Antibactericidal mechanisms of C5a-TLR2 cross-talk induced by P ARHA MYD88 TIRAP PMC3854412__F7 SIRT1 negatively regulates amyloid-beta-induced inflammation via the NFKB pathway IL6 RPE SIRT1 PMC5037286__F2 The NLRP3 inflammasome by the ubiquitin system NLRP3 TLR4 SHARPIN BRCC3 TRAF2 PMC5378051__F3 Homologous mammalian and fungal host-defense pathways that signal through prion conversion NLRP3 NWD2 PMC6657652__F2 Contrast inflammatory signals in human gingival fibroblasts triggered by the different acylation structures of P CD14 TLR4 LBP PMC6314538__F3 Cell cycle timing and regulation of replicative histone genes NPAT TBP NASP MYC TUT7 SLBP PMC5661375__F2 Function of TGFB1 in normal lung and lung cancer cell responses to radiotherapy SMAD2 SMAD4 PMC5661375__F1 TGFB1 signaling pathway SMAD2 SMAD4 PMC4424078__F1 Viral Activation of Cellular Metabolism HK2 FASN PMC6524506__F1 Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling: a new therapeutic target for inflammation? PI3 TLR4 IL1B PMC5721733__F8 Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway NLRP3 SIRT3 PMC6721535__F1 The catecholamine biosynthetic pathway in an adrenomedullary chromaffin cell or a pheochromocytoma cell TH VIT PNMT DBH LAT PMC6387316__F3 Pathways controlling the response of physioxia MSC chondrogenesis ADAMTS4 FOXO3A RUNX2 ACAN COL2A1 FOXO1 COL10A1 SOX9 PMC7109575__F1 Role of the Wnt/Beta-catenin signaling pathway in chemoresistance of colorectal cancer MMP7 APC GSK3B PMC8345981__F1 TGF-Beta as a Master Regulator of Diabetic Nephropathy SMAD2 TGFBR1 COL1A2 SMAD4 COL4A2 COL4A1 PMC11688252__F2 Key signaling events underlying D-lactate-induced metabolic reprogramming in bFLS HIF1A HEL-S-133P PMC6930194__F1 Schematic illustrating interaction of key elements in the tumor stroma in CCA progression PDGFD VEGFC CXCL1 MSC VEGFA IL6 CCL2 HIF1A PMC10688450__F4 Link between U2AF1 and NFKB signalling in MDS and AML U2AF1 MAP3K7 IRAK4 MYD88 CASP8 PMC8592571__F8 Proposed cold-induced vasoconstriction signalling pathway in young and aged mice TRPA1 TRPM8 PMC6160385__F5 Βeta-TRCP in regulating the Wnt signaling ZNRF3 LEF1 TCF3 APC MYC LRP5 CD44 LRP6 SKP1 GPR49 PMC8533541__F2 Bioactive Scaffolds Integrated with Liposomal or Extracellular Vesicles for Bone Regeneration BMPR2 CDK2 CDC2 BAX PMC5713305__F2 Nuclear factor erythroid 2-related factor 2 (Nrf2) regulatory pathway MAF GCLM FECH KEAP1 GCLC HMOX1 RXRA PMC3384412__F2 UPR signaling in diseases ATF4 EIF2A XBP1 PMC1327682__F3 Schematic overview of the Saccharomyces cerevisiae central carbon metabolism HEL-S-62p ENO1 ENO2 GPD2 CIT HEL60 MAL PMC4853753__F5 Cerebellum Development and Tumorigenesis: a p53-centric Perspective ATOH1 PTCH1 SHH CCND1 SMO RORA PMC6465609__F8 Schematic model of DHAV-1 inhibiting type I interferon signaling by hijacking the SOCS3 protein STAT1 OASL SOCS3 IRF3 TLR3 IFNG MX1 STAT3 PMC9205118__F8 Identification of the key flavonoid and lipid synthesis proteins in the pulp of two sea buckthorn cultivars at different developmental stages DGAT1 PC POLL LPA POLI PMC11878485__F1 The role of signaling pathways in the mechanisms of glaucoma in retinal ganglion cells apoptosis, optical nerve protection and regeneration, and the LC damage and remodeling RHO PTEN BDNF PMC10137309__F3 Extravasation steps in lung cancer brain metastasis AKR1B10 ADAM9 RHO CCL2 PMC10137309__F2 Extravasation steps in melanoma brain metastasis CXCR3 PLEKHA5 MMP2 PLG MMP9 CCR4 S100A4 PMC11878485__F2 Review of glaucoma related signaling pathways and their mechanisms BAD TRADD PLG ARHA PTEN TNF BDNF TRAF2 BAX PMC4192461__F11 Proposed schematic for the maturation of mNT and its role in exporting mitochondrial Fe-S and reactivating the cytosolic apo-IRP1 into Fe-S aconitase after H2O2-induced oxidative and nitrosative stress MNT FXN ISCU NUBP1 CIAPIN1 PMC11878485__F4 The Wnt/Beta-catenin signaling pathway APC LRP5 CCND1 LRP6 PMC7641192__F3 Calcium signalling pathway (map04020) obtained from KEGG database with official permission and guidance from Kanehisha Laboratories (permission ref 200,290) PLN BCR CAV3 MCU PMC10137309__F1 Extravasation steps in breast cancer brain metastasis MUC1 COX2 ADAM8 GBP1 SEMA4D CXCR4 MMP9 CD44 HBEGF HPSE CD24 PMC4388007__F4 Significantly affected canonical pathway “interferon signaling”, as determined by IPA® analysis IFIT3 IRF9 MX1 IFNG OAS1 PIAS1 BCL2 TYK2 JAK1 IFI35 IRF-1 PSMB8 SOCS1 BAX PMC6365940__F9 Pathway involved in gemcitabine-resistant pancreatic cancer cells with digoxin treatment MAF KEAP1 GCLC ABCC5 NQO1 PMC8264328__F1 One carbon metabolism in human lung cancer TYMS MTHFD1 HEL-S-51e MTHFD2 PMC4659372__F1 PD-1 signaling in effector T cells HDAC7 CD80 SIRT1 SKP2 FOXP3 PMC3385961__F1 Evolution of Wnt pathways APC GSK3B SRC RYK RHO PMC3031560__F5 Identification of Novel Molecular Targets for Endometrial Cancer Using a Drill-Down LC-MS/MS Approach with iTRAQ FGA DBI SFRP4 HEL-S-78p AHSG APOH APOA2 PMC8551152__F6 Schematic diagram HEL-S-26 ZDHHC19 E2F4 TIMP1 CD44 HIF1A TGFB1 CHI3L1 PMC3973207__F8 Schematic diagram showing differences in the thyroid cancer cell lines sensitive or resistant to apoptosis BAD BAX PMC4918620__F4 MAPK signaling pathway (orange nodes are associated with upregulated or only whole dataset genes and green nodes have no significance) CD14 NGF DAO MAX FLNA ATF2 TRAF2 MEF2C PMC3518257__F7 14-3-3 signaling canonical pathway from IPA BAD AIP GFAP GRB2 BAX CBL PMC4867619__F3 IPA analysis: (Panel a) Top Network Cell Death and Survival, Inflammatory Response, Cancer MMP12 HSPB2 FGF2 CD40LG SMPD1 MUC5B TLR3 PMC4405237__F1 Diversification of importinA isoforms in cellular trafficking and disease states RANBP1 RAN PMC7698114__F2 Difference of two variants of CDK20 CDK20 SNAPIN CDK2 CCNH PMC4483546__F1 Metformin on hepatocyte energy status and the mammalian target of rapamycin pathway, in turn affecting metabolism and inflammation TSC2 EGF TSC1 PTEN EIF4E MTOR DEPTOR RHEB PMC9573519__F2 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets FADD UCP2 BAX PMC9573519__F1 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets TLR9 HEL-S-28 MMP9 MTOR EN1 IL1B PMC8069505__F3 Important molecular mechanisms by which AEG-1 induces chemoresistance DPYD ALDH3A1 MTOR ABCB1 DKFZp686F0183 PMC9194098__F2 Traditional Chinese Medicine in Bone Regeneration and Osteoporosis SEMA3A BMP2 NRP1 GSK3B PMC10812436__F3 Main anti-inflammatory properties of HDLs VCAM1 CCL2 TNF PMC8348456__F1 Inflammatory Response in COVID-19 Patients Resulting from the Interaction of the Inflammasome and SARS-CoV-2 NLRP3 ACE2 IL1B TMPRSS2 GSDMD PMC9360520__F1 Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review SMAD2 SMAD4 PMC11600669__F1 Signaling pathway according to KEGG (A) NAFLD and (B) PPAR HEL-S-28 CAST LPL PMC7803009__F1 Congenital Malformations in Pregnancies with Pre-existing Diabetes DNMT3B PAX3 PMC10494486__F7 Signaling model for late-phase IP-10 induction by MRP8/14 in endotoxic mice STAT1 CXCR3 TLR4 IRF7 TYK2 JAK1 PMC6161739__F5 Current model of NLRP3 subcellular localization during its activation process.Notes: Primed NLRP3 is both cytosolic and associated with endoplasmic reticulum (eR) NLRP3 MFN2 MARK4 MAVS GSDMD PMC2603035__F3 Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease BMP2 PAH TGFB1 PMC8875910__F1 Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers BTK LYN SYK RAF1 MYD88 TIRAP PMC7092503__F7 Differentially expressed interactors of APE1 in colorectal cancer TIMM44 HSPD1 TXN HSD17B10 HEL-S-26 LAP3 UQCRC1 PDHA1 ILF3 DUT OGDH NADK2 ETFA SDHB CNP LIG1 UQCRC2 TUFM PMPCA NIF3L1 RPS3 CLIC4 SIRT1 ALDH2 FEN1 KYNU FH HEL-S-70p FKBP4 PHB2 TRNT1 FASN CLIC1 RAB35 ETFB RPS14 ACOT7 STOM CHCHD3 DBT IDH3B MPG SLC25A6 SLC25A3 TOMM40 HEL-S-51e MUTYH ECHS1 HEL-S-29 BCAP31 PMC7754013__F1 MicroRNAs in osteogenic transdifferentiation of VSMCs HEL-177 RUNX2 IGF2 SAMD5 STAB2 HDAC5 SAMD1 ACVR2A HDAC2 MSX2 CTNNBIP1 RHOB WNT7B PMC6161739__F2 NLRP3 inflammasome assembly NLRP3 TNF GSDMD PMC7507121__F2 TGFB signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 PARP1 FURIN CDK9 CDK8 PMC7468432__F1 Development and differentiation of Breg cells PREB CXCR4 CD44 CD19 CD24 PMC6161739__F1 Canonical and non-canonical inflammasomes.Notes: Canonical inflammasomes assemble downstream of cytosolic PRRs including NLRP1, NLRP3, NLRC4, AIM2, and pyrin and control the activation of caspase-1 NLRP3 NLRC4 NLRP1 AIM2 IL1B GSDMD PMC2803240__F8 Model of VA metabolism in neonatal rat lung LRAT CYP26B1 PMC6161739__F3 NLRP3 priming following TLR activation NLRP3 TLR4 IRAK1 IRAK4 MYD88 FADD TLR3 PMC7507121__F3 Tumor suppressor and promoting functions of TGFB signaling ANGPTL4 CXCR4 PMC7468432__F2 Activation of Breg cells IL21R BCR CD40 MYD88 IRF4 PMC5009326__F3 Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease KAT2B NUMB RAB11A MAML3 NRXN3 HDAC1 ADAM17 HES1 CREBBP GDI2 KAT2A RAP1A HEY2 EP300 PSEN1 APP SNW1 OTX2 SHC1 NCOR2 APOE PMC8003624__F3 Fungal induction of necroptosis RIPK1 CARD9 BCL10 TRADD RIPK3 SYK TRAF2 FADD MLKL PMC4266326__F2A Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation IL24 IFNB1 IL25 PMC4881529__F4 GPCR-mediated transactivation of EGFR EGF ADAM12 EGFR SRC ADAM10 ADAM17 PMC4286677__F8 Scheme of interactions hypothesized to connect the receptor protein Draper to the execution of the engulfment process SRC RHO CDC42 PMC4881529__F3 Diversity in GPCR-mediated regulation of Wnt/Beta-catenin APC GSK3B PMC7236057__F8 Possible mechanisms of La2O3 NPs contributing to the apoptosis of testes tissues KEAP1 NPS CYP17A1 IL1B PMC4181723__F7 Proposed TLR signaling mechanism by CS14K: a hypothetical model of TLR4 signaling, pathway activated by fusion protein, in a MyD88-independent fashion STAT1 TRAF6 IRF3 MYD88 TNF PMC8361327__F2 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer CADM1 TWIST1 PMC8361327__F1 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer CADM1 YAP1 FRMD6 PMC5534384__F2 The diversity and plasticity of adult hepatic progenitor cells and their niche EGF LTA HGF LTB BMI1 TNF TGFA PMC7773908__F7 Positive crosstalk between epidermal growth factor receptor (EGFR) and the platelet-activating factor (PAF) pathway in cervical cancer cells PC EGFR LPCAT2 PMC7157599__F3 Molecular mechanisms used by members of the HECT E3 ubiquitin ligases to regulate Wnt, TGFB and Notch signaling pathways UBR5 SMAD2 SMURF2 APC HUWE1 WWP1 SMURF1 NEDD4 ITCH PMC1828071__F2 Insulin-mediated activation of PI3K signaling pathways TSC2 PDE3B RICTOR BAD TSC1 PDK2 GSK3A EIF4E MTOR EIF4B RHEB PMC8472694__F2 Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism MFN1 MFN2 GPR75 PC MCU PSD PEMT PMC1828071__F3 Diagrammatic representation of insulin on growth factor signaling through the Ras-Raf, MEK-ERK signaling pathway with downstream effects on gene transcription through ERK translocation GRB2 GRB10 CRK PMC3501223__F1 Role of Esrrb in ESC self-renewal and reprogramming SALL4 TCF3 SOX2 ESRRB LIF PMC6450419__F4 Watch what you (self-) eat: Autophagic mechanisms that modulate metabolism PINK1 HERC2 PARK2 SQSTM1 NUFIP1 OPTN PMC3866688__F5 Targets of immunosuppressive drugs used in solid organ transplantation, according to the 3-signal model of T-cell activation CD2 IL2 CD40 JAK3 CD80 MTOR PMC7890028__F1 Wnt signaling pathways and their modulation by pharmacological molecules APC RYK PMC5428427__F8 Proposed model for the suppression of inflammatory cytokine production by globular adiponectin in LPS-stimulated macrophages ADIPOR1 ADIPOR2 IL16 KEAP1 TRAF6 PMC6966193__F2 S1PC induces the degradation of MyD88 and Pax5 by activating autophagy PAX5 IRAK4 CCL2 MYD88 XBP1 PMC8484567__F6 Dramatic transcriptomic differences in Macaca mulatta and Macaca fascicularis with Plasmodium knowlesi infections IFIT3 CXCL1 SOCS3 TRAF3 USP18 MX1 IFNG OASL DTX3L ISG15 IL18 TLR4 IRF-1 AIM2 ERFE IL10 STAT2 IRF7 IRF8 IRF9 BST2 CXCL10 IRF3 IKBKB ISG20 CXCL9 CD40 TYK2 TRAF2 SOCS1 MAVS PMC7889583__F1 Multiple MDSC-mediated immunosuppressive mechanisms STAT1 COX2 IL16 APC MMP9 MYC CCND1 MYD88 CYBB ARG1 ADAM17 STAT3 PMC3986565__F1 Molecular pathways leading to cross-presentation in DCs ERAP1 TAP2 PMC3902304__F1 TWEAK/Fn14 signaling cascade TRAF5 RELA RELB TRAF6 FURIN TRAF2 PMC7889583__F3 Resistance mechanisms to MDSC immunosuppression TLR4 EBP MYD88 STAT3 PMC12250417__F4 Signal transduction mediated by BCR, FcRL1, CD19, and BCMA receptors on B-cells BTK FCRL1 BCR LYN GRB2 ARHA SYK PLCG2 SOS1 PCNA CDC42 CD19 PMC9598604__F1 Impact of an Adapted Physical Activity Program on Bone Turnover, Physical Performance and Fear of Falling in Osteoporotic Women with Vertebral Fractures: A Quasi-Experimental Pilot Study IL10 MSC PTH IL6 IL1B PMC9440249__F10 E-375i elicited anti-PCa effects MMP7 MMP9 BCL2 PTPN4 PARP1 STAT3 PMC12119567__F4 Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities SOAT1 MTOR PER2 PMC8389199__F8 Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway KEAP1 GCLC NQO1 BAX PMC10379831__F1 Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis BAD SOX2 MYC PTEN IL6 MTOR SOX9 TSC2 ZEB2 MDM2 BCL2 SMO AXL TF PMC7438746__F4 Transcriptional regulation by mTORC1 MAF TFEB HIF1A NR1C1 STAT3 POLI PMC3176402__F4 Zn and Zn transporters are indispensable for FcERI-mediated mast cell activation FYN GAB2 ARHA PMC7438746__F3 Indirect transcriptional control by AMPK through metabolites of intermediary metabolism TET3 OGA OGT SIRT6 TET2 TET1 PMC3547956__F6 Transcriptional and Gene Regulatory Network of Lactococcus lactis MG1363 during Growth in Milk OGT RELA PURB ADK PMC5334292__F1 The possible role of the polyol pathway in diabetes atherosclerosis NAMPT TF NDP PMC5105243__F2 Possible mechanisms for neuroprotective function of exercise and differences between sexes FGD4 KMO GJB6 DDIT4 IGF2R PMC3082570__F1 Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules Inhibit Tumor Formation and Metastasis of a Human Model Breast Cancer Cell Line BAD FOS CCND1 SRC MTOR STAT3 PMC2322867__F2 Rapid Signaling Mechanisms of Estrogens in the Developing Cerebellum EGFR GRB2 SRC HBEGF PMC8551128__F1 Complement activation in IgA nephropathy CD59 CLK1 MASP1 FH C6 MASP2 C1S PMC4301092__F2 Examples of PTM-mediated biological processes PRMT1 PTMS MDM2 PMC3587843__F4 Lipids in The Control of Autophagy PI3 PC PIKFYVE PMC11097647__F6 B cell receptor signaling pathway-enriched Module_01 KLHL6 HRH2 ICAM2 PCDH7 CHRNB4 ZP3 BLK CD79B TLR10 CACNA1A DGKA KNDC1 CD22 ADA CDK5R1 DMRTA1 FMNL3 PTPN6 GCNT4 CD19 PMC5689203__F1 Schematic representation of secretory protein folding and quality control, the unfolded protein response pathway, and the heat shock response HSF1 PMC9171972__F2 YAP1 in liver cancer stem cells: proven and potential mechanisms IGF1R YAP1 IGF2 LRP5 LATS1 IGF2R PMC3475803__F7 A model depicting ATM- and NEMO-mediated NFKB activation upon accumulation of prelamin A isoforms CXCL1 ATM RELA PMC3742223__F1 Ageing-dependent decline in thyroid activity, leading to compensatory increases in cellular D1 activity and thyroid hormone metabolites that may, through non-genomic pathways, be involved in amelioration of ageing related metabolic disturbances IMPACT INS TRO SIRT1 INSR PMC8204022__F4 MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation MYB PDE4D PIK3R1 SNAI1 KDM5B RUNX1T1 CRY2 BMI1 SIX1 HIF1A LIN28A CBFB STAT1 CSF1R TIMP3 ACSL1 ASCL2 SP1 FLI1 FOS ERG YAP1 TP63 ATF3 CEBPA PBX2 PGRMC1 tal-1 NTF3 MEGF9 E2F7 MAX TWIST1 SLC10A7 SPRYD4 KLF4 TP73 TMEM64 RORA SIRT1 PNRC1 FOXM1 NR3A2 SLC8A1 PSMD9 RELB PTEN CEBPB THRA FOXP3 BMP4 NHLRC3 F2 ATF4 E2F2 ZBTB16 CPEB3 HOXA10 BANP HAND2 GATA3 NR1H4 LIN28B KAT2B HOXB7 EGR1 SOX2 RUNX1 FOXO3A HECW2 NFE2L2 RPS6KA5 KLF5 EED GATA2 HNF4A EP300 TRIM32 PAIP2 NFKB1 RELA ATOH8 KDM4A TCF4 STAT3 PMC10373120__F5 Regulatory pathway involving lncRNA H19, miR-124-3p and ITGB3 in modulating ectopic endometrial cell proliferation and invasion in endometriosis ITGB3 ACTA2 PMC5077967__F8 microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NFKB BCL2A1 TRADD CSF3 RELA RELB CXCL2 REL CSF1 PMC6915012__F7 Schematic representation of the PAME-induced G2/M arrest in hBM-MSCs MDM2 CDC2 PMC10880550__F1 Effect of acetylcholine released from cholinergic neuron on heart, visceral smooth muscles and the brain TRPC4 KCNQ2 TRPC5 PMC9511018__F2 Non-cytotoxic functions of CD8 T cells: “repentance of a serial killer” CXCL10 CXCL9 IFNG CCL3 PMC6061679__F1 Parkinson’s disease genes reveal an association of multiple variants that converge on deficiencies in cellular clearance VPS35 NPC1 LRRK2 LAMP3 VPS13C HEL-S-130P ALAS1 PINK1 KAT8 TMEM175 SLC17A5 MCCC1 RAB39B SMPD1 COQ7 PMC7118073__F7 Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression PTEN EZH2 UFC1 PMC10880550__F5 Complex interactions among GIRK, TRPC1/4/5 and KCNQ channels with GPCRs via G proteins A or BG subunits and PIP2 in neurons TRPC4 TRPC1 TRH TRPC5 PMC2173816__F3 Down-regulation of the inflammatory response CASP3 CASP9 PMC7946926__F8 Transport mechanism TEC MAPK1 PMC6596994__F7 A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1 TBK1 CGAS IRF3 PMC6905042__F2 Proposed mechanisms of Wnt/Beta-catenin dysregulation in ovarian cancer ZNRF3 RAB14 RNF43 LRP5 LRP6 TNKS CCNG2 SOX7 JRK PMC3243033__F1 Regulation of epidermal homeostasis by PCP signaling GPC4 FUZ PTK7 ARHA CELSR1 RAC1 CELSR3 GRHL3 CTHRC1 CELSR2 DAAM1 ROR2 VANGL1 CDC42 PMC8721007__F2 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy CPT1A HEL-S-133P ACADM HK2 CD36 HEL-S-5 GLS PMC6905042__F1 The Wnt/Beta-catenin signalling pathway APC GSK3B PMC155355__F7 Model outlining the roles of GAI/RGA-like GA-signaling components in the plant life cycle FGA RGL3 RGL2 PMC4562157__F5 Genes involved in metabolism (EMP pathway, TCA cycle, and inositol metabolism), rhizosphere adaptation, biocontrol, and plant growth promotion in SQR9 and their expression patterns in response to root exudates PGM2 XYLB COMP HEL60 THRA PMC8721007__F3 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy PIG59 ENO1 GCK HK2 CD36 HEL-S-68p HEL-S-5 PMC7185105__F9 Hypothetical scheme of molecular and cellular events in the cochleae of aging Tg-B1 mice leading to accelerated hearing loss ULK1 MTOR PMC10380881__F1 Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study KDM1A MTR DHFR MTRR TYMS PMC3374856__F3 Mutations in glutamate signaling pathway and its associated proteins in melanoma NRG3 ERBB4 GRM3 NRG2 NRG1 NRG4 PSD PMC8866648__F2 Vascular Stem/Progenitor Cells in Vessel Injury and Repair DKK3 LRP5 CCND1 LRP6 PMC12138082__F2 Antiviral mechanism of miR-124, miR-24, and miR-744 STAT1 RARA MAX MYC HMGN1 PMC8012850__F6 Schematic representations of the gene regulatory pathway controlled by Oc factors in the chordate retina NRL PAX7 RXRG CACNA2D3 PROX1 PAX3 FOXN4 SCGN GABRA2 SLC7A14 NR1A2 GABRA6 CPLX2 PDE6D TMTC2 LHX5 PMC2810615__F1 Simplified overview of the canonical Wnt/Beta-catenin signaling pathway LRP5 LRP6 PMC7145982__F1 Autophagy process and regulation of ATG proteins by PTMs PINK1 ULK1 ATG12 ATG3 ALG12 ATG101 ULK2 UVRAG ATG10 DKFZp686F0183 PMC10974036__F12 Recent Advances in the Nutritional Value, Chemical Compositions, Pharmacological Activity, and Application Value of Orychophragmus violaceus: A Comprehensive Review MAF KEAP1 ATF4 JUND PMC10937455__F1 The intrinsic immune system in the pathogenesis of GN NLRP3 CD14 MYD88 PMC12138082__F8 Vital role of the AMPK signaling pathway in cellular progress CRY1 TSC2 TSC1 HNF4A TXNIP MTOR ATG14 PMC3917352__F1 Major metabolic pathways in tumour cells HEL-S-26 ACLY HEL-S-133P GLS PMC3403522__F2 Intracellular HIF-1A regulation pathway in normoxia and hypoxia EGFR VHL MTOR HEL-S-133P PMC4453221__F1 Wnt/Beta-catenin signalling pathway APC SOST LRP5 LRP6 SFRP1 PMC8830536__F2 Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease CCR2 TLR4 RUNX2 BMP2 LPA PMC12138082__F4 Proviral mechanisms of miRNAs TBK1 IRAK1 IRF9 TRAF3 TRAF6 IL6 MYD88 RIPK2 MAP3K7IP1 STAT1 GAB3 TYK2 JAK1 CXCL12 IRF-1 MAVS STAT3 PMC12138082__F3 Mechanism of miR-342-5p regulating sterol metabolism STAT1 ABCG1 EVL IDI1 ABCA1 IRF-1 HMGCR PMC11046063__F1 NRF2 signalling pathway KEAP1 RBX1 PMC2789670__F5 Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C GCLM MAFF KEAP1 GCLC HEL-S-64p HEL-75 GLRX BACH1 PMC9032805__F3 Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression TMEM67 SLC14A1 MAP2K1 MAP2 RAB25 COXFA4 NOTO COX6A1 ATP6V1F CP PMC6287681__F3 Signaling pathways by which NPs induce apoptosis CASP3 CASP6 CASP12 BAK1 APAF1 CASP9 CASP8 FADD CYCS BAX PMC6287681__F2 Signaling pathways that induce necroptosis RIPK1 RIPK3 CASP8 FADD PMC10145673__F2 Molecular pathways involved in pituitary tumorigenesis TSC2 BAD TSC1 IGF1R SUFU APC EGFR MDM2 SMO LATS1 PTEN RHEB PMC10145673__F1 G-protein-coupled receptor (GPCR) signaling pathway AIP AHR EGFR SRC MTOR PMC12069192__F2 Regulation mechanisms of LMM proteins in rice RAB5A RBL1 RFWD2 PMC6287681__F4 Autophagy signaling pathways induced by NPs ULK1 PI3 ATG16L1 ATG12 ATG3 ATG10 TG ATG14 DKFZp686F0183 PIK3R4 PMC3185509__F1 Activation of antiviral and proinflammatory responses during HSV infections TLR9 IRF7 IRF3 MYD88 TLR3 MAVS MAPKAP1 PMC3185509__F3 Innate immune evasion mechanisms of HSV RNASEL TLR9 IRF3 TLR3 MAVS PMC3625183__F7 Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells PGP ARHA OTP PMC9179574__F3 Genetic Structure and Molecular Mechanisms Underlying the Formation of Tassel, Anther, and Pollen in the Male Inflorescence of Maize (Zea mays L.) SPI1 SOS1 PMC11357136__F2 Several modulator molecules linked to the signaling of GLP-1 receptor within the PI3K/AKT/mTOR pathway are demonstrated RICTOR ULK1 NGF PTEN PMC8431684__F2 Therapeutic Potential of Targeting the SUMO Pathway in Cancer RARA PML PIAS2 ERG SENP1 PIAS1 SUMO1 PMC8579463__F8 miR-34a-5p functions as a tumor suppressor in head and neck squamous cell cancer progression by targeting Flotillin-2 CDK4 CDH2 CDK6 FLOT2 PMC4882535__F5 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine PRKCI HEL70 PGR MAPK3 VEGFA TUBB1 LCN2 CXCL8 EZR ARHA RDX LAMA3 PS1TP5BP1 PRKCA CASP3 CASP9 PARD6A PARD3 COL4A5 PMC4882535__F4 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine PRKCI HEL70 PGR MAPK3 VEGFA TUBB1 LCN2 CXCL8 EZR ARHA RDX LAMA3 PS1TP5BP1 PRKCA CASP3 KDR CASP9 MAPK1 PARD6A PARD3 COL4A5 PMC5413082__F1 Schematic of growth hormone and IGF-1 axis IGF1R IGF1 GHR GHRH PMC9417995__F7 Schematic description of TRAF4/SMURF2-mediated regulation of HER2 signaling and Trastuzumab resistance in HER2+breast cancer cells SMURF2 MTOR TRAF4 PMC4655423__F1 Development of innate lymphoid cells RUNX3 GIG8 AHR IL33 NFIL3 IL25 RORA TOX TSLP IL1B GATA3 IFNG PMC3117004__F2 Updated most likely pathway for acylCer formation (November 2010) DGAT2 ELOVL4 TG PMC2150790__F9 The signaling pathways activated by N ERBB2 GRB2 CD44 SRC RHO CDC42 PMC11983503__F3 Regulatory mechanisms of D-catenin associated with neural development and function RICTOR APC SHANK3 PMC6520728__F6 Schematic diagram for a proposed molecular mechanism of CFH regulation in lung cancers SOCS3 CFH STAT4 SOCS1 PMC11983503__F2 CTNND2 involved in the WNT/Beta-catenin pathway FGFR1 SETD6 APC PAK4 HIF1A PMC2967651__F1 A model for interplay between alloimmunity and autoreactivity in graft rejection TH IL2 HEL-S-92n IFNG PMC7764362__F4 Main action mechanisms of chloroquine (CQ) and hydroxychloroquine (HCQ) related to antiviral and immunomodulators properties STAT1 TLR7 TLR9 IRF7 IRF9 IRF3 TLR3 PMC3343200__F5 IL-6 contributes to a positive feedback cycle of growth and invasion between CAFs (myofibroblasts) and its underlying tumor (afferent pathway) and between invading tumor and the recruitment of fibroblasts to myofibroblasts (efferent pathway) EGF NOTCH3 STAT3 PMC2697824__F3 Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review ATM EGFR RAD51 ATR PMC7764362__F2 Negative regulation of interferons (IFNs) by autophagy TBK1 TLR9 STAT2 IRF7 IRF9 IRAK2 NLRX1 TRAF3 IRAK4 IRF3 IFNAR2 MYD88 IFNAR1 NOD2 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 MAVS PMC3843069__F1 Tryptophan metabolic pathway ASMT HEL-S-90n KYNU DDC MAOA AFMID AANAT PMC11722366__F2 Key signaling pathways involved in kidney fibrosis HEL-S-28 SMAD2 SMAD4 TBR1 TYK2 JAK1 TGFBR3 TNF STAT3 PMC3291810__F8 PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling PAK1 RAF1 STAT3 PMC8833906__F1 Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia SQLE PCSK9 INSIG1 DHCR24 HMGCR PMC3147301__F3 Towards an understanding of the adjuvant action of aluminium TH NLRP3 IL33 MYD88 PMC4412056__F1 LC-PUFA biosynthesis pathway {adapted from Refs FADS2 ELOVL5 FADS1 ELOVL2 PMC5407765__F9 IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria CXCL10 IL33 CXCL9 PMC9613427__F1 Gain-of-function TLR7 and loss-of-function A20 gene variants identify a novel pathway for Mendelian lupus and lupus nephritis TLR7 BCR IRF7 MYD88 PMC7879300__F1 Toll-Like Receptors Regulate the Development and Progression of Renal Diseases TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 PMC313952__F6 Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals EGF CIRSR EGFR GRB2 SOS1 CBL PMC11900975__F2 Multiple mechanisms of T-cell exhaustion induced by neutrophils in the TME ALPL NAMPT NTRK1 CD69 STAT3 PMC3594247__F1 Hippo on the move LATS1 LATS2 PMC8776955__F5 Calcineurin-dependent NFAT signaling as shared signaling pathway for IBD and SCZ PRKCZ BAD PRKCE HEL2 PPP3CA MAPK8 SFN HEL-S-1 CSNK2A1 PPP3CC MAPK3 MEF2D FKBP1A YWHAG NFATC1 NUP214 NFATC3 CASP3 NFATC2 PPP3R1 EP300 PRKCB BCL2 MAP3K8 RAN HEL-S-93 PMC11931784__F8 Heatmap of DEGs involved in the JA synthesis pathway MYC PMC5110454__F1 DRAStic RHOAdblock of Pyrin inflammasome activation IL10 HEL-S-62p IL16 PKN2 MVK ARHA IL6 PKN1 MEFV PMC9482886__F2 AMPK regulation of the mTOR pathway and control of cell growth and autophagy TSC2 ULK1 TSC1 DEPTOR RHEB MLST8 PMC3926678__F5 Repetitive hypoxic preconditioning suppresses adaptive immune responses in resident B cells prior to stroke HLA-E HLA-G HEL-S-99n HLA-DQB1 IL12A HLA-DMA STAT1 CCR7 IL17RA IL4 IRF-1 IRF4 BAX H2AB1 SET STAT2 HLA-DOB IRF3 TNF HLA-DRB1 HLA-B BCL6 NFKBIB CREBBP EP300 CD40 REL PMC5506009__F1 Functions of experimentally verified target genes of miR-17-92 were analyzed by GeneMANIA using genetic interactions, pathway, and physical interaction parameters ZBTB7A MYC NRAS RB1 CCL1 E2F3 FGFR2 BMPR2 KDR TNFSF12 ARIH2 CASP8 IRF2 VEGFA CDKN1A BCL2 KLF2 ZNFX1 NR3A2 MYLIP TGFBR2 PTEN YES1 BCL2L11 BNIP2 CCND2 MEF2D NPAT GPR137B ATM E2F2 F3 APP CCND1 FBXO31 THBS1 RBL2 SELE KAT2B KIT TSC22D3 MAP3K12 HSF2 ITGB8 CPEB2 PTPRO JAK1 SOCS1 DNAJC27 STAT3 PMC6770178__F1 Substance P/neurokinin-1 receptor (SP/NK-1R) system regulates several cell signaling pathways involved in cancer progression APC GSK3B RHO GPR49 MTOR PMC4401129__F1 Tie2 (Tie2 tyrosine kinase receptor) structure and Ang-1-Tie2 signallingsignaling PLG MAFK RAC1 ARG1 PMC4364006__F2 The molecular regulation of autophagy ULK1 ATG12 ATG3 AMBRA1 PTEN ULK2 ATG10 DKFZp686F0183 VMP1 RHEB TSC2 TSC1 UVRAG ATG14 PMC7654218__F6 Effects of extracellular antagonists in the Wnt/Beta-cat signaling pathway during the proliferation and differentiation in human osteoblast DKK3 APC LRP5 LRP6 DKK4 PMC3715701__F1 Myosin 1c in cellular signaling pathways PAK1 CTBP1 SRC RAC1 IRS1 CDC42 PMC6520171__F3 Depiction of RBP4 immunomodulatory actions locally within and how this gives rise to insulin resistance APC RBP4 IL1B PMC5501910__F3 Rescuing the BMPRII signaling pathway in pulmonary arterial hypertension SMAD4 SMAD1 DKFZp781O1323 PMC3660063__F3 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response TSC2 BAD TSC1 EIF4E MTOR DEPTOR EIF4B RHEB BAX PMC8301375__F4 XBP1s in Transcriptional Regulation of Target Genes PIN1 EP300 MYC HIF1A XBP1 SIRT1 PMC3660063__F2 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response EGF DUSP5 EGFR GRB2 PMC3660063__F1 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response PIK3R1 ULK1 IRS4 FKBP3 PTEN MTOR DEPTOR RHEB PIK3R4 TSC2 PIK3R5 NF1 TSC1 PIK3CA PMC6928565__F1 Notch3 signalling and vascular remodelling in pulmonary arterial hypertension RBPJ JAG2 ADAM10 ADAM17 PMC8301375__F1 XBP1s in Transcriptional Regulation of Target Genes ELF2 ATF4 EIF2A XBP1 PMC6766623__F12 Molecular mechanisms by which pretreatment with monophosphoryl lipid A (MPLA) suppresses LPS signaling in the medullary thick ascending limb TLR4 IRAK1 MYD88 PMC12153709__F7 Graphical representation of the IL-4/IL-13 signaling pathway, including the genes described in Table 1 IL13RA2 CCL26 IL13RA1 TYK2 JAK3 JAK1 STAT3 PMC3069698__F1 The Fanconi Anemia and Breast Cancer Susceptibility Pathways FANCD2 BRCA2 ATR USP1 PMC8044463__F3 Metabolic genes regulated by Mondo family ME1 DGAT2 FACL4 MOGAT2 ELOVL6 TG MTTP GFPT1 DGAT1 FADS2 F2 ELOVL5 DCT FADS1 ACSL1 TXNIP KHK ACLY HEL107 HEL-S-133P SCD5 PMC5916398__F1 Initial stages of the sensitization in contact dermatites TH TLR4 TNF TSLP IL1B PMC9304701__F1 Trained Immunity and HIV Infection TLR4 IGF1R ABCA1 PMC3660063__F4 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response NF1 TSC2 ULK1 TSC1 GRB2 PTEN MTOR DEPTOR IRS1 RHEB MLST8 PMC8082500__F8 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs CYR61 EGR1 KDR BCL6B SMAD6 KLF4 ATOH8 MMP23B PMC4343072__F6 Consequences of mutant BRAF V600E in LCH BRAF MYD88 ARAF PMC8082500__F7 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs CYR61 EGR1 KDR BCL6B SMAD2 SMAD6 KLF4 SMAD4 ATOH8 MMP23B PMC8131834__F2 Targeting Parthanatos in Ischemic Stroke PC AIDA SIRT1 PMC7916866__F1 Oxidative Stress, Plant Natural Antioxidants, and Obesity IGF1R IGF1 NPY AgRP IRS1 PMC8698543__F3 Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells TRADD TNF FADD BAX PMC6210393__F7 MAPK signaling pathway from KEGG database CD14 EGF TRADD FLNA MYC TNF NLK MAX MAFK GRB2 ECSIT RAF1 MEF2C PMC11978054__F5 Visualize interactions between the hub-genes in a co-expression blue module using GeneMAINA LIN28B IGF2BP1 HBD KRT19 PDE3A MGLL SNTA1 UBE2E2 IGF2BP3 HEPH CDK14 HBB CAV2 CAPRIN2 NR1A2 ARHGEF37 SOX6 NEURL1B GCNT2 LMCD1 ANKRD36B GPR65 COL4A5 PMC2785525__F1 The Anticoagulant APC Pathway PLG APC F11 TF PMC11076649__F8 JCYSTLF exerted an anti-senescence effect through regulating the HIF-1A/autophagy pathway in diabetic kidneys STX17 DKFZp686F0183 PMC10139088__F6 Metabolic regulation on tumour metastasis SNAI1 SNAI2 PMC7010257__F5 miRNA expression in advanced Algerian breast cancer tissues ERBB2 ERBB3 EGFR MDM2 EZH2 EIF4EBP1 PMC7642854__F3 Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling PI3 INS PTEN IRS1 PMC10139088__F5 Metabolic plasticity regulation on tumour microenvironment FBP1 CIC PMC2785525__F2 Cytoprotective APC pathway VCAM1 APC PMC7381294__F5 Differentially methylated genes enriched in the insulin signaling pathway TSC2 TSC1 PDK2 INS EIF4E MTOR FOXO1 RHEB PMC3049195__F1 Proposed diphthamide biosynthesis pathway DPH2 DPH5 DPH3 DPH1 PMC7381294__F7 Differentially methylated genes enriched in the AMPK signaling pathway LEPR STAT3 PMC7381294__F6 Differentially methylated genes enriched in the adipocytokine signaling pathway SOCS3 LEPR NR1C1 STAT3 PMC6770718__F1 Schematic drawing presents the detailed signaling pathways of breast carcinogenesis EGF HGF SMAD2 TRAF6 PMC7172007__F1 Canonical Wnt/Beta-catenin signaling pathway and pharmacologic pathway mediators SFRP4 APC GSK3B LRP5 LRP6 PMC4988654__F1 Major steps in the retinol signaling pathway of vertebrates HOXA1 RDH10 DHRS3 ALDH1A2 PMC2246264__F9 Proposed mechanism for MnSOD-mediated mitochondria to nucleus signaling and crosstalk with the IIS pathway DUSP10 NFKB2 PTEN REL RHEB PMC7211957__F7 Model illustrating the Thbs1/integrin/YAP signaling pathway in remodeling of vessel walls LATS1 THBS1 LATS2 PMC5342520__F2 Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies ROCK1 PTEN ATP2A1 PPIF PLCB1 CCND2 PPP1CC ITPKC CAV3 ZYX DGKZ ITPKA GNAL CALML3 ACTN4 PLCD3 SHC1 PMC3160828__F1 More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases STAT1 RUNX3 STAT4 IL12RB1 GATA3 PMC8898375__F10 Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway CPT1A ATL3 SIRT1 SIRT3 PMC9286785__F5 BACE1: More than just a B‐secretase BACE1 UCP1 LEPR STAT3 PMC9286785__F4 BACE1: More than just a B‐secretase BACE1 PTEN IRS1 STAT3 PMC4191651__F3 Schematic illustrating mechanisms of SR-A intracellular signaling TLR9 IRF3 MYD88 TLR3 MVP PMC11977285__F3 Extracellular vesicles (EVs) in mitigating MASLD HGF FOXG1 ARG1 ADRB3 STAT3 PMC3356623__F6 Influence of Tc-axin and Tc-pangolin on canonical Wnt signaling and role of Wnt signaling in axis formation in the bilateria APC PMC7263617__F4 Expression of high mobility group B1 and toll-like receptor-nuclear factor KB signaling pathway in chronic subdural hematomas HMGB1 TLR4 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC9219682__F1 Enhanced 3T3-L1 Differentiation into Adipocytes by Pioglitazone Pharmacological Activation of Peroxisome Proliferator Activated Receptor-Gamma (PPARG) COX2 EBP LPL PMC5920280__F1 Metabotropic actions of kainate receptors (KARs) in the regulation of glutamate release in the hippocampus HEL-S-11 CA3 PMC11968765__F2 Signal transduction mechanism of SWELL1 in different tissues and cells CDK2 YBX1 GRB2 CCND1 BCL2 JUN FOXO1 NSUN2 BAX PMC8660088__F6 System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer MYB BAD CSF3 FOS CSF3R MYC RAC1 IRS1 CFTR RXRA TLR4 AMH BCR GRB2 PIK3CA CCND1 SYK RAF1 BDNF JUN CD19 PMC4096159__F2 Emerging Role of Autophagy in Alcoholic Liver Disease TSC2 TSC1 PTEN MTOR RHEB PMC11173950__F3 Oxidative stress: Nrf2 signaling pathway (adapted from Hammad et al KEAP1 RBX1 PMC11782603__F8 Using SEC-MX to provide molecular insights NPRL2 GNS C16orf35 DEPDC5 MAP2K4 AKT1S1 EIF4EBP1 DEPTOR RHEB MLST8 TSC2 CHEK2 RPS6KB1 TSC1 RPS6KA1 CDC2 RRAGA SESN2 ATR CDK9 PMC8544255__F4 Deregulation of the canonical Notch signalling pathway during CRC treatment BCL2 ABCG2 CCND3 HES1 PMC8544255__F3 Deregulation of the canonical Wnt/Beta-catenin signalling pathway during CRC treatment APC LRP5 BCL2 LRP6 USP22 BCL9 PMC8911851__F6 Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics NF1 TMED5 TMEM43 NRP1 COQ9 FAAH SEC11A PMC5666614__F3 Lipids at membrane contact sites: cell signaling and ion transport ESYT1 ORAI1 STIM1 PMC7848762__F4 This network represents the interactions among the top-ranked genes participating in fusions in (A)T-cell acute lymphoblastic leukemia and (B) B-cell acute lymphoblastic leukemia KMT2A LMO1 KIN CCND3 tal-1 LMO2 PMC8544255__F2 Deregulation of the canonical PI3K signalling pathway during CRC treatment BAD GAB2 EGFR MDM2 PTEN EIF4E JAK1 RPS6 GAR1 PMC6781449__F10 Kindlin-3/leupaxin complex regulates paxillin tyrosine phosphorylation and podosome stability LIM2 F2 F3 PMC8544255__F1 Deregulation of the canonical MAPK signalling pathway during CRC treatment STAT1 RPS6KB1 BRAF ATF2 MYC GRB2 MAPK14 KIN JUN CDC42 PMC4702137__F8 Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu NUMB CCND1 PMC5028860__F1 Red nodes indicate the query proteins and the proteins present in the dotted circles, VTN, PRKACA, RELA, EP300, AKT1, EIF2C1, are the common proteins associated with the query proteins SPARC KAT5 YBX1 VEGFA IGFBP7 DKFZp686F0183 NRP2 ASIP POMC HEY2 KDR EP300 NPY AgRP RELA VTN RRP8 USP22 VEGFB XB EPHB2 PMC3985661__F8 Schematic representation of PARP1–TDP1 coupling for the repair of Top1–DNA covalent complexes PARP1 MRE11A TDP1 PMC10390051__F3 Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections IMPACT GFAP GDNF ACE2 S100B TMPRSS2 PMC8774252__F2 Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3E) VLDLR CDK5 DAB1 CRK NDEL1 PMC5427221__F1 Various roles of C3 in complement activation and effector functions HEL-S-62p AFP CD46 BCR CR2 CR1 CP PMC8881125__F7 4-Octyl Itaconate Prevents Free Fatty Acid-Induced Lipid Metabolism Disorder through Activating Nrf2-AMPK Signaling Pathway in Hepatocytes KEAP1 PMC8843894__F2 Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants NLRP3 CRP IL1B PMC5423858__F1 MicroRNA function in Drosophila memory formation POLL RAN POLI PMC7294616__F10 Anti-inflammatory signaling pathway mediated via OXA and OXR2 in ICH IL10 HP OXR1 PMC2925528__F1 Summary of the systemic involvement of choline-containing species and their potential relationship with inflammatory processes LTA PC PMC1850660__F1 Summary of established Beta-catenin pathways APC GSK3B PMC4755791__F3 Toward an Orofacial Gene Regulatory Network KDF1 dik TFAP2B MAX SMAD2 TP63 SMAD4 TFAP2C NOTCH1 OVOL1 GRHL3 IRF6 PMC3537922__F1 Unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses TBK1 CD14 TANK TLR4 UNC93B1 TRAF3 TRAF6 CD40 IRF3 MYD88 TLR3 TIRAP PMC8662335__F7 REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/Beta-catenin signaling pathway BTK REC8 PMC8650799__F3 Metabolic alterations reinforce pro- and anti-inflammatory macrophage phenotypes ARG1 IL1B IFNG PMC7164247__F8 Proposed model for antigen presentation by astrocytes in the PD brain CD80 PMC7858229__F1 Major forms of inflammatory cell death CASP3 RIPK1 TRADD RIPK3 CASP8 FADD MLKL GSDMD DFNA5 PMC6357482__F6 Schema of miR-21 regulated PTEN, PDCD4, SPRY2 pathway PTEN LPA SPRY2 PMC6357482__F8 Schema of miR-205 regulated ZEB1, ZEB2, EMT pathway ZEB2 PMC9317057__F1 Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies AMOT NF2 TAOK3 LATS1 RHO LATS2 TAOK1 TAOK2 PMC9620778__F8 MAPK signaling pathway. The red nodes represent CN–NI-related genes CD14 MAX APP COIL GAL STH TRAF2 PMC9098816__F2 Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death HMGB1 MYD88 TNF PMC8948417__F4 RET receptor signaling: Function in development, metabolic disease, and cancer RET GDF15 NTS GFRAL PMC8074527__F1 Mevalonate pathway involvement in viral mechanisms FDPS ARHA IPP RHOB PMC5777751__F6 Protein–protein interaction networks of differentially expressed proteins CXCR3 ChAT SRC PMC3295657__F6 Pathway model for interleukin (IL)-1A and tumor necrosis factor (TNF)-Alpha-induced inhibition of human skeletal muscle cell (HuSKMC) differentiation ALK SMAD2 ATF2 PMC7285260__F6 N starvation and disruption of cyto-nuclear coadaptation on allantoin synthesis and degradation PMC7864210__F1 ERA:E2 signaling network and crosstalk with growth factor signaling SRC MTOR TF PMC9104295__F3 Procyanidins and Their Therapeutic Potential against Oral Diseases BAD SMAD2 NOTCH1 MTOR PMC8203325__F4 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges TRADD MYD88 TNF TRAF2 FADD PMC8203325__F3 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges MMP2 MMP9 CCND1 FURIN PMC7081551__F1 Summary diagram of miRNAs, lncRNAs and circRNAs participated in the drug resistance of gastric cancer PMC5123688__F6 TLR8 couples SOCS-1 and restrains TLR7-mediated antiviral immunity exacerbating West Nile virus infection in mice TLR8 TERT BAX PMC6306791__F8 Possible molecular targets of the preventive effects of PT in Cr(VI)-induced ACD NLRP3 ACD IL1B PMC4479417__F10 PI3K-C2G is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling PI3 MTOR APPL1 PMC7996871__F2 PERK pathway and small molecule modulators BACE1 KEAP1 QRICH1 ATF4 PMC7996871__F1 Unfolded protein response (UPR) pathways KEAP1 ATF4 EIF2A TRAF2 XBP1 PMC4013413__F2 Roles of ALK in the pathogenesis of ALK+ anaplastic large cell lymphoma (ALCL) SNAPIN BAD ALK GRB2 SRC JAK3 JUNB MCL1 MTOR IRS1 STAT3 PMC11638488__F7 Mechanism of Trp in alleviating MS CYP27A1 CYP8B1 FGF19 CYP7B1 FGFR4 CYP7A1 PMC7772020__F1 Central metabolic regulation of ferroptosis SQLE ADA PMC7782843__F1 Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies BAD BRAF MYC GCK RAC1 HRAS HSF1 GRB2 APP SRC BCL2 RAF1 TRAF2 JUN SHC1 ARAF CDC42 PMC9468923__F5 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor IL16 AHR MTOR PMC4643087__F3 Ingenuity pathway analysis (IPA) revealed a key role for the Molecular Mechanisms of Cancer set of pathways BAD APC MYC RHO CRK IRS1 CBL NF1 LEF1 PC MAX ATM SUFU CD2 MDM2 GRB2 BCL2 SMO JUN FADD RBL1 CYCS BAX PMC9468923__F1 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor AHRR AHR CYP1B1 PMC4909418__F1 Smoothened-dependent and Forkhead box C1 transcription factor-induced Smoothened-independent Hedgehog signaling FOXC1 PTCH1 SMO PMC5973839__F1 Hyperglycemia enriches metabolic flux to glycolysis and five principal branches including the polyol pathway, pentose phosphate pathway (PPP), hexosamine pathway, protein kinase C (PKC) pathway, and advanced glycation end-products (AGE) pathway HEL-S-49 GLO1 ENO1 HAGH SORD HEL-S-162eP PMC7936150__F6 Heme and protoporphyrin IX biosynthetic pathway ABCB6 FECH UROD SLC25A5 ABCB7 UROS PMC8107692__F6 Resistin-Like Molecule A Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes ACADS CPT1A POLG2 POLRMT PDK4 TFAM NR1C1 ACADM PMC4122349__F2 Serum miRNA Signature in Moyamoya Disease TSC2 RICTOR TSC1 INS MTOR EIF4B RHEB PMC9686909__F2 Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia TNF FADD BAX PMC2666541__F1 (panel A) ODC expression is regulated by a number of signaling pathways COX2 COX1 APC MYC PMC4478945__F8 Folate- and vitamin B-12–mediated one-carbon metabolism MTR DHFR TYMS HEL-S-51e MTHFD2 PMC11726948__F8 Summary diagram of AGH treatment in mdx mice FOXO1 MYOG DMD PMC5308739__F3 Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network EGF BAD EPO FRK RALA JAK1 TGFA AKT3 PMC2901551__F1 mTOR signal pathway TSC2 RICTOR TSC1 PRR5 PTEN MTOR DEPTOR IRS1 RHEB MLST8 PMC8185338__F1 Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria ULK1 NR1i1 ATG3 LAMP2 ULK2 MTOR ATG14 PMC11816720__F3 Molecular mechanisms of kynurenine pathway in liver diseases AHR KMO CYP1A1 PPP1R15A PMC12174442__F4 CO2-fixation metabolic pathways in autotrophic microorganisms RTCA ACLY HEL-S-162eP PMC11816720__F1 Kynurenine pathway (KP) IDO1 HEL-S-90n KMO IDO2 PMC5479626__F7 Illustration of Hippo-p53 pathway in megakaryocytes (MKs) MDM2 ARHA LATS2 PMC3731320__F1 Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway TNF NOD2 PMC6262325__F1 Canonical hedgehog signaling pathway KIF7 SUFU SMO PMC2754444__F5 T-Cell Activation Pathways Generated by HIV-Modulated Proteins CD3D ZAP70 GRB2 NR0B2 SRC IL2 WAS SHC1 CRKL CBL PMC5597599__F2 Model Signaling Network SOCS3 PTEN MCL1 HIF1A PMC5597599__F1 Model Signaling Network SOCS3 ATF2 MAPK14 PTEN HIF1A PMC8632388__F7 Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD NLRP3 GSTA4 TLR4 PC PTEN ACLY MTOR NR1C1 CD36 PMC9659888__F2 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer NLRP3 NLRP1 AIM2 IL1B GSDMD PMC9659888__F1 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer NLRP3 RIPK1 TNF GSDMC IL1B FADD GSDMB GSDMD STAT3 DFNA5 PMC11620901__F4 ACL injury management: a comprehensive review of novel biotherapeutics TSC2 EGF PAK1 SMAD2 SMAD4 ARHA PMC3269300__F1 DN Tregs employ multiple mechanisms to exert antigen-specific control over immune responses CD80 CTLA4 IFNG PMC5738678__F1 Functional mechanism of the Notch signaling pathway NOTCH4 DLL4 JAG2 NOTCH1 DLL3 NOTCH3 PMC7991918__F7 Targeted molecular and biological pathways’ interaction map analysis performed on the genes from the red module HEL2 EHD1 HEL-S-99n CNDP2 SNAP25 HEL-S-87p RAP2A PRNP FKBP1A VAPA PFN2 PTPN1 HGS HEL-S-77 ACTR2 SNX1 PMC8552375__F1 NAD+, Senolytics, or Pyruvate for Healthy Aging? PC EPO PMC8611496__F9 Noni on cellular viability and osteogenic differentiation of gingiva-derived stem cells demonstrated by RNA sequencing and quantitative PCR BAMBI E2F4 NODAL BMP2 PITX2 SMAD2 THSD4 TGFBR1 SMAD4 SKP1 ARHA TNF RBX1 BMP4 IFNG FST THBS1 PMC3956536__F5 Heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway ATM CCNB1 RAD51 CDC2 ATR H2AX PMC8417127__F2 Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy CCR6 CCL20 PMC6081569__F10 Nuclear effects of DRD1/PKA pathway and reactive species on postsynaptic neurons CDK5 FOSB POLI PMC5892644__F6 Cycloartobiloxanthone Induces Human Lung Cancer Cell Apoptosis via Mitochondria-dependent Apoptotic Pathway BCL2 MCL1 BAX PMC8372480__F1 SARS-CoV-2 infection of islet B cells: Evidence and implications NRP1 ACE2 TMPRSS2 PMC7494909__F5 Intercalated disc protein XinB is required for Hippo-YAP signaling in the heart NF2 LATS1 CDH2 LATS2 PMC3421055__F3 IMPACT OF ALTERED METHYLATION IN CYTOKINE SIGNALING AND PROTEASOME FUNCTION IN ALCOHOL AND VIRAL-MEDIATED DISEASES HEL-S-61p HEL-S-182mP PC PEMT PMC6416106__F2 Glutamine metabolism and macrophage polarization HEL-S-26 IL16 ABAT PMC9219854__F2 Importance and Value of Porcine Species in Sialic Acid Research ST6GAL2 GNE ST3GAL3 ST8SIA4 ST8SIA5 ST8SIA6 ST8SIA2 ST8SIA1 ST3GAL6 SIAT4C ST6GALNAC6 CMAS NANS ST6GALNAC4 ST3GAL1 ST6GALNAC2 NANP ST6GALNAC1 ST6GAL1 ST3GAL5 PMC5723588__F2 Haem synthetic pathway FECH UROD UROS CPOX PMC6287190__F1 Classic and alternative pathways of bile acids synthesis CYP27A1 CYP8B1 CYP7B1 BAAT PMC4918816__F2 Comprehensive Review of Pacritinib in Myelofibrosis SOCS1 PMC6822144__F6 Schematic diagram showing role of Tbx15 on adipocyte browning and obesity PRDM16 UCP1 ATF2 PMC6888001__F8 G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules VEGFC EGFR PMC6523352__F2 Heme activator proteins (HAP) complex HEL-S-26 COX14 C9 C7 CYC1 COX10 C6 COX11 MRPL40 HEL-S-32 COX5A MRPL11 PMC9235271__F5 Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonance spectroscopy in patients with community-acquired pneumonia ALB CRP CIT PMC8836080__F1 Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases SFRP4 LRP4 SOST LRP5 LRP6 PMC4789259__F1 Canonical miRNA biogenesis pathway DGCR8 DDX1 DROSHA RAN PMC3099728__F8 Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression IGF1 RUNX2 PTEN FOXO1 PMC4026919__F1 Wnt signaling pathway APC GSK3B RYK RHO FGF9 PMC5294960__F1 Canonical and non-canonical TGFB signaling pathways SMAD2 TGFBR1 MAP3K7 SMAD4 TRAF6 ARHA MTOR TRAF4 PMC4695108__F3 Regulation of Bim in Health and Disease DNCL1 USP9X GADD45A BRCA1 PMC4705949__F10 Proposed mechanism utilized by HDACi to inhibit osteoblast-mediated protection of AML cells PPL NHERF1 HEL-S-69p PMC2648232__F6 Pathway mapping of OPC differentiation inducer genes TRPC4 DUSP10 MBP NLGN3 DLG4 PMC8742403__F9 ROS/PI3K/Akt and Wnt/Beta-catenin signalings activate HIF-1Alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer ENO1 HEL-S-133P HK2 PMC3146023__F3 Human spermatogonial stem cells: a possible origin for spermatocytic seminoma RET FOS GDNF PMC6297255__F8 Model proposing ROCK inhibition mediates morphological shift and neurite outgrowth-promoting property of OECs L1CAM TGFBR1 TGFBR2 ARHA PMC8188762__F2 SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease TSHR TPO TG PMC8375263__F1 One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency MYD88 SOCS1 TIRAP PMC4230790__F3 Key signaling nodes in prostate cancer that regulate epithelial plasticity ERG EGFR IL6 PTEN EZH2 CDH2 CLU STAT3 PMC9322748__F11 Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor BACE2 GPX1 BAAT PMC9207015__F1 Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population TRAF6 MYD88 TAB3 PMC12010937__F7 Illustrated summary of the proposed roles of hepatic and intestinal FXR signaling pathways in TPHP-induced bile acid metabolic disorder and MASLD development in mice, based on the findings of this study TH CYP7A1 PMC4240281__F4 Molecular mechanisms of epithelial–mesenchymal transition HEL-S-28 PTCH1 GSK3B GRB2 TRAF6 SMO STAT3 PMC3960720__F8 Q43L mutant of neuregulin 2B is a pan-ErbB receptor antagonist ERBB4 EGFR NRG2 PMC7275069__F3 FOXF2 acts as a crucial molecule in tumours and embryonic development TRAK1 SHOX2 PDGFRA FOXF2 TNFRSF19 TRAF6 FGF18 PAX3 FOXF1 BMP4 EYA1 PDGFA FGF3 PTCH1 SLCO2B1 SHH PMC7275069__F2 FOXF2 acts as a crucial molecule in tumours and embryonic development VEGFC FOXF2 TWIST1 TIMP3 SP1 FOXC2 PMC8391356__F5 Galanin during Bacterial Infection in Larval Zebrafish XCR1 IL21R IL13RA1 TGFBR1 GFAP CSF3R TGFBR2 IL11 IL6 TNF MTOR PRL OSMR CSF1R IL20RA NGFR IL17RA CD40LG IL6ST MCL1 IL4 IL10RA PMC3961843__F1 Selected glucose metabolic genes and their potential roles in tumor development OGT GCK GFPT1 HK2 PMC4156617__F1 Updated working model for the AR showing a bifurcated signaling pathway downstream of cAMP/Epac PMC11083344__F4 BCAR3 in cell cycle progression CDK2 SRC ARHA CDK4 CDK6 CDC42 PMC7988727__F6 Prenatal indole-3-carbinol administration activates aryl hydrocarbon receptor-responsive genes and attenuates lung injury in a bronchopulmonary dysplasia model  TRADD TRAF2 PMC8203325__F2 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges TSC2 TSC1 GRB2 PTEN RHEB PMC8203325__F1 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges DAAM1 FLNA APC GSK3B LRP5 ARHA PMC9051474__F2 Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars IPP PMC7483234__F3 Correlation of multiple markers of cell death signaling pathway in the hippocampal dentate gyrus (DG) of postmortem AUD human brain TNFRSF25 TRADD PMC2570545__F2 EGFR signalling pathway in lipid rafts PI3 BAD PC EGFR MTOR PMC5712312__F1 Synthesis of glucosylceramide (GlcCer) and its complex glycoshingolipid metabolites NHS DES GAL GBA2 PMC8122946__F6 Gene Coexpression Network Analysis Indicates that Hub Genes Related to Photosynthesis and Starch Synthesis Modulate Salt Stress Tolerance in Ulmus pumila GIP PMC3432059__F6 Establishment of Mouse Teratocarcinomas Stem Cells Line and Screening Genes Responsible for Malignancy ROCK2 NLK SIAH1 STOM APC CER1 SKP1 ARHA PMC8875122__F1 Fungal Colonization and Infections—Interactions with Other Human Diseases TH CARD9 IL16 SYK MTOR PMC6456212__F8 A carnosine analog with therapeutic potentials in the treatment of disorders related to oxidative stress COX2 SIRT3 PMC6885086__F4 Effects of sulforaphane on Nrf2 and NFKB pathways MAF KEAP1 SFN GSK3B PMC7868022__F4 EBV-induced oncogenesis through the MAPK signaling pathway ABI2 DUSP8 PMC7868022__F3 EBV-induced oncogenesis through the JAK/STAT signaling pathway NKX6-3 HLX SPIB JAK3 BCL2L11 STAT3 PMC5108588__F8 Hypothetical model explaining the dysfunctional Wnt–Beta-catenin signaling in PPARG deficiency GSKIP APLN GSK3B PMC5034935__F3 Proposed mechanisms by which the interaction of dietary long-chain n-3 polyunsaturated fatty acids from fish oil and butyrate from bacterial fermentation of dietary fiber may reduce colon tumorigenesis CASP3 CASP6 HEL-S-11 PMC7868022__F5 EBV-induced oncogenesis through the TGFB signaling pathway SMAD2 SMAD4 PMC7868022__F2 EBV-induced oncogenesis through the PI3K/AKT signaling pathway GSK3B CCL5 MTOR PMC3928694__F2 TLR signalling pathways: TLRs signal through myeloid differentiation primary response gene 88 (MyD88) or/and TIR-domain-containing adapter-inducing interferonB (TRIF)-dependent pathways TLR7 TLR4 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TIRAP PMC7868022__F1 EBV-induced oncogenesis through the NFKB signaling pathway CDH6 NKIRAS2 PINX1 PMC12227979__F5 Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation TSC2 NPB BAD BCR SYK RAC1 EIF4E POR MTOR RBL2 CD19 PMC4721599__F4 Network of genes located within high-level copy number changes and deregulated across all of the cell lines and tumors IER3 PERP CDC6 MYC DKC1 TOP2A PDLIM3 ATAD2 AURKA PMC6139685__F16 Tentative Model Explaining Redirection of Metabolism in the Absence of MDH2 during Photoautotrophic N Deprivation.FA degradation starts with hydrolysis of TAGs and membrane lipids by lipases MDH2 MAL PMC6365454__F2 Chronic hyperglycemia impairs neuron function HEL-S-62p BDNF TRPV1 PMC4979470__F1 The NLRP3 inflammasome signaling pathway NLRP3 TNF IL1B PMC9183236__F9 Regulating alveolar formation through mitochondrial activity and distribution MMD PDGFRA RHOT1 PDGFA TFAM PMC6296439__F6 A model for the effect of JCAD CAD risk genotype on the Hippo signaling pathway LATS1 RHO JCAD LATS2 PMC4288261__F2 N-terminal tyrosine residues of SLP-76 on the canonical TCR signaling pathway PLCG1 ITK FYN CSK FOS LCK GRB2 REL JUN PMC3126106__F3 Chemosensory processing in the taste – reward pathway PLCB2 TRPM5 TRPA1 PMC4848008__F3 The HA/CD44 signaling pathway leading to the malignant phenotype of cancer cells SOX2 CD44 CCND1 STAT3 PMC3248170__F1 Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers IGF1R BRAF ARAF PMC4848008__F2 The hedgehog (Hh) signaling pathway and FAK cooperation with NANOG and p53 in the CSC phenotype PTCH2 PTCH1 SMO PMC5341142__F2 Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders EGR1 PDGFRA SP1 PMC7859453__F3 Activation of ERBB family receptors by growth factors can activate RAS MAPK signaling EREG EGF AREG RHO LPA PMC7859453__F2 MST activation center is the Hippo path EREG EGF NF2 AREG PMC7859453__F1 MOB, RASSF, SAV scaffolding proteins play an essential role in activating the Hippo pathway EREG EGF NF2 AREG AJUBA PMC7658374__F1 TGF beta SMAD-dependent signaling pathway BMPR2 ACVR2A TGFBR2 PMC4062952__F1 Four androgen metabolism pathways to DHT synthesis AKR1C2 CYP17A1 PMC6916680__F5 Suppression of proliferation and invasion and enhanced apoptosis of breast cancer cells by inhibition of expression of PI3K and its downstream signaling pathway by oxymatrine CDK2 MMP9 GSK3B CCND1 PMC10934115__F1 Genome-wide DNA methylation profiling identifies hypermethylated genes that are linked to regulation of multiple oncogenic signaling pathways in response to resveratrol (RSV) in breast cancer cells PRKCA PRKCB PTCHD1 WNT16 WNT4 PITX2 PTCH1 MAML2 PLCG2 MTOR RPS6KA2 AKT3 PMC10910747__F8 Working model: BMP9/BMP10/ALK1/SMAD4 Signaling drives the regulation of direct and indirect pathways in ECs BMP10 ERG PTGS2 SMAD6 SMAD4 CDK4 ID1 HAS2 SMAD1 DKFZp781O1323 SELE PMC4271587__F3 Flux map for accession 3231 (13C-MFA) HP CIT MAL PMC5964128__F3 Dex represses expression of phagosome formation-associated genes MARCKS LTA VTN SYK RHO DKFZp686L24211 PMC3606787__F8 Significant signaling pathway networks mined from nitroproteomic dataset TWIST2 PTPRK ZNF267 IRAK2 GRIP2 FEZ2 PCDH7 RHPN2 BMF PLD3 UBB LIMA1 UBC CAP2 NFRKB KLK11 ARHGAP5 FCAR RAB32 SNAP91 MMD FOS RPN2 RAB31 PSMA2 STC1 ARHA TNF TPD52L2 BCL2 ESPN TMOD3 TGFB1 PMC9476772__F10 Assessment of pulmonary infectious disease treatment with Mongolian medicine formulae based on data mining, network pharmacology and molecular docking KY RELA APP PMC9323014__F8 Runx2 in Microtubule Acetylation in Bone Metastatic Breast Cancer Cells RUNX2 ATAT1 PMC3434621__F5 Interactions of Rex with host pathways, uncovered and covered UBA2 PIAS2 SP100 PMC3637685__F2 GAIT-mediated translational control ELF3 EIF4E HEL-S-162eP PMC2903975__F1 TLR signalling pathways: All TLRs except TLR3 share a common initial signalling pathway through MyD88 to the IRAK1/2/4TRAF6 complex TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC5845754__F10 Proposed model for Marf-mediated ER stress in FRDA flies FH FXN PMC9448792__F8 Altered glucocorticoid receptor signaling in the diabetic proximal tubule ALDOB PCK1 FBP1 FKBP5 PMC12128433__F7 Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation PLCG1 APC IL2 CD69 IFNG PMC7427806__F5 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP RELB CXCR5 EZH2 TRAF2 ICOS HEL-S-162eP PMC8487962__F1 Complement activation and its effects in periodontitis HEL-S-62p MASP1 MASP2 PMC2940266__F2 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles BAD APC GSK3B MDM2 PTEN PMC2940266__F1 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles BAD GSK3B MDM2 GSK3A PTEN MTOR PMC7427806__F4 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP ARHA ICOS TET2 PMC5316546__F1 Our strategy to increase seed oil accumulation by overexpressing the plastidial pyruvate transporter BASS2 under the control of a seed-specific promoter in developing A PC GPT ABCA9 HEL-S-5 PMC8349734__F5 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study HSP90AB1 BCL2 PMC8349734__F4 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study BCL2 PMC11941171__F11 Mechanism of action of SJB2-043 in A549 cells MTOR USP1 PMC7659166__F4 CeRNA network directly associated with hypertensive nephropathy TUG1 AKT3 PMC7188552__F2 Bile acid synthesis pathways CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC4475396__F1 REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination MAD2L2 CDC20 RIF1 APC POLN BRCA1 PMC6970952__F3 Pathview analysis of the EGFR tyrosine kinase inhibitor resistance signaling pathway EGF IGF1R BAD HGF BRAF EGFR GSK3B BCL2L1 PTEN MTOR PRKCA RPS6 AXL ARAF BAX FOXO3A PDGFRA FGF2 VEGFA FGFR3 EIF4E HRAS PIK3CA BCL2 JAK1 TGFA SHC1 STAT3 PMC7218056__F3 Hippo pathways in lymphocytes FOXO3A FLNA DOCK8 ARHA LATS1 RAC1 DENND1C MOB1A MOBKL1A FOXO1 LATS2 F3 RAB13 PMC4833475__F1 Insulin Signaling and Heart Failure TSC2 ULK1 TSC1 IGF1 GSK3B BCL2 EIF4E MTOR IRS1 PDPK1 CD36 PMC4243705__F4 CHROMOSOMAL INSTABILITY PATHWAY IN COLON CANCER TIAM1 TBK1 GRB2 RHO PMC10878151__F4 Phosphorylated SMAD2/3 signaling pathways regulate the process of HCC SMAD2 SMAD4 PMC10878151__F2 Crosstalk between TGF‑B/SMAD and other pathways SMAD2 SMAD4 MTOR JUN PMC10878151__F1 Structure of the SMAD family and overview of TGFB/SMAD and BMP/SMAD signaling pathway HP SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC4389409__F2 Plant phytochemicals achieve hormesis through multifocal pathway inhibition PTEN MTOR SIRT1 PMC3996849__F3 Intestinal cholesterol absorption is a multistep process regulated by multiple genes ABCG8 ABCG5 NPC1L1 TG MTTP HMGCR ACAT2 HEL-S-5 PMC11855393__F5 Targets of immunotherapy in triple-negative breast cancer (TNBC) CD80 TIGIT LAG3 PMC11855393__F4 EGFR, FGFR, PI3K and MEK pathways and their potential inhibitors in triple-negative breast cancer (TNBC) EGF EGFR PTEN MTOR PMC3270101__F6 Pathway map related to cisplatin-induced hepatotoxicity based on proteomic and genomic analysis APOB FBP1 ASB1 ARG2 GSTT2 ARG1 MTTP MDH2 FASN PMC11855393__F3 Cancer stem cell-associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) ECD SMAD2 LRP5 SMAD4 PTK7 LRP6 STAT3 PMC11855393__F2 AR and associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) CDK4 PTEN MTOR CDK6 PMC8403114__F2 Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis IHH SCX SOX9 PMC8355560__F2 An Overview of Novel Agents for Cervical Cancer Treatment by Inducing Apoptosis: Emerging Drugs Ongoing Clinical Trials and Preclinical Studies HMGB1 ATM SI opn EGFR NOTCH1 MSH2 MTOR STAT3 PMC7352566__F1 DNA Double Strand Break repair by Homologous Recombination or Non-Homologous End-Joining pathway RIF1 SHLD3 BRCA2 SHLD2 RAD51 BRCA1 PMC7284830__F1 Examined genetic variants involved in folate and vitamin D metabolic pathways RFC1 MTR HEL-S-11 DHFR MTRR TYMS MTHFD1 PMC9356005__F3 Underlying mechanism of Treg in skeletal muscle repair and regeneration AREG IL33 CCL2 PMC8617942__F2 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus LEP POMC SOCS3 NPY LEPR STAT3 PMC8617942__F1 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus POMC AgRP INS MTOR FOXO1 INSR PMC3904668__F1 CD180 is a close relative of TLR4 and together with BCR signaling can promote B-cell activation and differentiation TLR4 BCR VAV1 CD180 MYD88 PMC3626870__F4 Arsenic-mediated disruption of PI3K/AKT signaling pathway BAD MDM2 PTEN RAC1 MTOR CDC42 PMC6934036__F5 Inhibitors used for antitumoral therapy ZNRF3 RNF43 TBP CDK14 APC GSK3B MYC LRP5 LRP6 GPR49 BCL9 PMC9929774__F5 Bioinformatics analysis of differentially expressed genes in diabetic foot ulcer and preliminary experimental verification NLK IGF1 ATM INS KLF2 PTEN BNIP3 SKP2 INSR PMC7045974__F2 Differential dependency network focused on the KEGG apoptosis pathway () CASP6 BAD NGF TRADD ATM MYD88 TRAF2 FADD BAX PMC12080384__F2 Mode of action of non-coding RNAs in tumors MDM2 PTEN SP1 STAT3 PMC12080384__F4 Multifaceted roles of RBP-regulated non-coding RNAs in tumors UBXN1 CD47 MYC DROSHA TFRC PTEN LATS1 HIF1A PIGK RBM25 FUS NF2 HNRNPC RBFOX2 STAT3 PMC3350990__F2 Bioinformatic analysis of the differentially expressed proteins.The list of the MS-identified protein spots from 2D-DIGE was subjected to String (v GNB2 G3BP2 DUSP3 HEL-S-72p DLAT DLG4 PMC3253915__F2 Innovative Therapy for Classic Galactosemia - Tale of Two HTS EGF EGFR PTEN PMC12114667__F1 CK1E’s role in the Wnt/Beta-catenin signaling pathway SNAI1 BIRC5 APC VSNL1 MYC SNAI2 CCND1 PMC4802755__F1 Schematic depiction on exogenous LIF mediated intra-cellular signaling pathways for robust self-renewal in mESCs SOX2 LIF STAT3 PMC8349295__F7 Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway KEAP1 GSTA3 HMOX1 PMC7432680__F1 Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes TLR4 ATM ABCG1 ABCA1 TG CD36 PMC7985688__F6 Illustrative model of the mechanism underlying the neuroprotective effects of PROG and ALLO against ketamine-induced cognitive deficits EGFR PGRMC1 BDNF PMC8332860__F8 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells TLR4 GEM IL33 POR MRO TNF H2AX OSM FADD TLR3 PMC9322447__F3 Fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2 MMP2 SMAD2 TGFBR1 TGFBR2 SMAD4 PMC8332860__F7 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells MYB BAD MEI1 GEM PTEN RAC1 POR RHEB TSC2 BCR APIP SYK MCL1 EIF4B RBL2 CD19 PMC8332860__F6 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells TH BAD MOS REN DAO GEM LPO LPA POR CRK CBL RET F2 SUFU KITLG SMO CAD ATR FADD PMC4074825__F3 FHIT-substrate complex as a signaling molecule FHIT EGF SRC PMC6826306__F6 Pathway enrichment analysis of genes with eQTL associations with identified disease-associated SNPs AIRE UNG CD8A RAG2 RFXAP BTK TAP2 BASH IL2RG LCK ZAP70 ADA CD40 RFXANK ORAI1 ICOS ELL CD19 CD36 PMC10944245__F10 Cytotoxic effect of flavonoids resulted from nuclear factor erythroid 2 (Nerf-2), Ak strain transforming (Akt), and nuclear factor kappa B (NFƙB) pathways KEAP1 PTEN MYD88 PMC4338832__F2 Drug targets in the autophagic pathway to treat human cancers ULK1 PMC6842984__F1 Diagrammatic representation of known mechanisms of action of lithium in endocrine cancers TBX1 GSK3B BCL2 PAX8 BAX PMC8027318__F2 Proposed model of signaling crosstalk for the BCR to induce CSR BTK BCR AID RELA TRAF3 RELB CD40 SYK PLCG2 MYD88 TRAF2 PMC7058824__F1 Vitamin D Metabolic Pathway CYP2R1 DHCR7 GC CYP27B1 PMC9267050__F2 Therapeutic Potential of the Restoration of the p53 Protein Family Members in the EGFR-Mutated Lung Cancer EGFR MDM2 BAX PMC7056731__F5 Interplays between Hippo signaling and ROS production TLR4 KEAP1 IRAK1 IRAK4 LATS1 MYD88 TLR1 TRAF2 LATS2 PMC8083902__F2 Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis PINK1 BNIP3 TG PMC8585639__F6 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets NLRP3 RIPK3 ACE2 IL1B ADAM17 GSDMD PMC7056731__F2 Reciprocal augment of Hippo-YAP signaling and innate antiviral response TBK1 CGAS STAT2 IRAK1 IRF9 IRAK2 TRAF3 IRF3 IFNAR2 LATS1 IFNAR1 LATS2 TLR3 STAT1 TYK2 JAK1 MAVS PMC8001359__F9 ISL effect on TGFB1 induced epithelial-mesenchymal transition (EMT) in human endometrial cancer SMAD2 SMAD4 CDH2 TGFB1 PMC7056731__F1 Simple scheme of the Hippo pathway in mammalian cells EGF NF2 LATS1 LATS2 PMC8585639__F4 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 RIPK1 TLR7 TLR4 TIRAP PMC7056731__F4 Crosstalk between Hippo-YAP pathway and NFKB signaling CXCL1 TLR5 TLR9 TRADD IRAK1 TRAF3 TRAF6 IRAK4 CXCL2 IRF3 LATS1 MYD88 TLR1 IL17RC MAP3K7IP1 LATS2 TLR8 TLR7 TLR4 TRAF5 TRAF2 TAB3 PMC7056731__F3 Mutual activation of Hippo-Yorkie pathway and Toll/IMD mediated anti-bacterial response in Drosophila MYD88 FADD PMC5037084__F1 Molecular mechanisms contributing to liver steatosis following hepatitis B virus infection APOB SCD TG FABP1 PMC12034938__F8 Plantamajoside Promotes NGF/TrkA Pathway to Inhibit Neuronal Apoptosis and Improve Diabetic Peripheral Neuropathy NGF BCL2 BAX PMC7226887__F1 Role of PTEN in the control of cell signaling BAD PTEN SIRT1 PMC6260831__F2 Deregulated Signaling Networks in Pancreatic Cancer BRAF APC TEAD4 PTEN LATS1 MTOR MOB1A CDK6 RHEB TEAD2 TSC2 NF1 TEAD3 TSC1 CCND1 CDK4 STAT3 PMC11124422__F3 APS on ICIs, CAR-T therapy, and DC cancer vaccines within the TME CD80 MTOR PMC6771966__F1 Mutual interactions of the mitochondrial compartment with hepatitis viruses and the consequences on the infections TBK1 CGAS IRF7 IRF3 MAVS IFNG PMC11124422__F2 Mechanism by which APS induces apoptosis in cancer cells by interfering with the cell cycle, inhibiting signal transduction pathways, and inducing apoptosis SOCS3 TRAF6 MYD88 MTOR CDK6 TLR4 RELA CCND1 CDK4 TIRAP TRAF4 STAT3 BAX PMC9144176__F1 Targeting Membrane Trafficking as a Strategy for Cancer Treatment GSK3B CCND1 PMC9469619__F1 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway TWIST2 KIF7 SOX2 SUFU GLI3 FAM98A SHH SMO PMC9469619__F2 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway DHH BOC VEGFC CDON IHH KIF7 SUFU PTCH1 GLI3 MYC SHH SMO PMC8714827__F2 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer FBLN5 EGF IGF1 VTN EGFR MTOR PMC7000168__F1 Summary of myocardial cellular effects and the injury response induced by doxorubicin CASP3 TLR4 NFAT5 BRCA2 MTOR GATA4 PMC1783401__F6 Integration of Runx1 and the BMP signaling pathway into the SCL transcriptional network RUNX1 ERG SMAD6 SMAD1 BMP4 GATA2 PMC8714827__F3 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer EGF EGFR GRB2 SRC PTEN MYD88 MTOR PMC8305424__F3A Genomic Approach to Delineating the Occurrence of Scoliosis in Arthrogryposis Multiplex Congenita EGF FLNA BAIAP2 APC ARHA CRK GNG12 GRB2 LBP HEL114 PXN TRIO CDC42 PMC7334043__F2 Primary metabolic pathways of R ME1 IDI1 LPA HEL60 HEL-S-32 MDH2 HEL-S-49 HEL-S-26 AOX1 PEX10 ACO2 GPD2 GPD1 PMC8613465__F2 Signaling pathways and intervention therapies in sepsis HMGB1 PINK1 TLR4 SESN2 MTOR AIM2 HDAC1 GSDMD PMC6155173__F5 RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation RIPK1 TLR4 TRADD RIPK3 TNF TLR3 MLKL PMC8613465__F1 Signaling pathways and intervention therapies in sepsis HMGB1 TBK1 CGAS GPX4 ALK EGFR IRF3 MYD88 HIF1A MAP3K7IP1 HDAC1 GSDMD IL18 TLR4 TXNIP PMC8613465__F3 Signaling pathways and intervention therapies in sepsis EPOR TFPI APC KLF2 TF PMC4427301__F4 Downregulation of Notch Signaling Pathway in Late Preterm and Term Placentas from Pregnancies Complicated by Preeclampsia NOTCH2 HEY2 DLL4 JAG2 DLL3 NOTCH3 PMC8516728__F2 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 TLR7 TRADD STAT2 IRF7 IRF9 ACE2 TLR3 ADAM17 TMPRSS2 STAT3 PMC8516728__F1 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 RELB CSA2 TNF PMC6784827__F1 Schematic presentation of mechanotransduction and inflammasome signaling NLRP3 PKN2 ARHA SYK AIM2 PKN1 PMC5882306__F7 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells CASP3 CASP12 ATF4 EIF2A CASP9 BCL2 DIABLO PMC5882306__F5 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells CDC6 ORC6 ORC1L CDT1 DBF4 ORC3 CDC45 ORC2 PMC5606087__F8 Connection among hub genes predicted on KEGG pathways AMOT HEL-S-1 TGFBR1 YWHAG PMC3646763__F7 Beyond the Binding Site: In Vivo Identification of tbx2, smarca5 and wnt5b as Molecular Targets of CNBP during Embryonic Development TCOF1 EGR1 CNBP WNT5B SMARCA5 PMC5882306__F4 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells BAD HIPK2 DAO F8 MYC TG CRK CBL NLK MAX ATM SUFU CD2 GRB2 SRC UNK ATR JUN FADD CRB2 RBL1 CYCS BAX PMC5882306__F3 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells CANX AMFR JUP EBP ATF4 HEL-S-99n BCL2 GIP VCP TRAF2 XBP1 PMC3684427__F5 The regulation of clot formation (colored entities) TFPI APC TF PMC3841024__F4 Representative ingenuity pathway analysis (IPA) of relationship between significant genes involved in the response to mechanical stretch and/or BIRB796 treatment in engineered cardiac tissues EREG DGIC PDGFD CALCA FOSL1 FOXO3A PTGS2 IGFBP5 CEACAM1 PMC8480435__F2 Example of oncogenic signaling and downstream metabolic and physiologic imaging changes during molecular therapies TSC2 TSC1 MYC PTEN EIF4E RHEB PMC8300228__F2 Antimicrobial Peptides from Black Soldier Fly (Hermetia illucens) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming MYD88 FADD PMC5858852__F7 Pathways enriched for genes associated with ovarian cancer BAMBI CSGALNACT1 CKS2 HEL-S-53e FGF13 HSD17B2 SOX17 LPAR3 GADL1 FGF9 AOX1 MMP7 ATP6V1B1 PSAT1 EVI1 SFRP1 GLDC WNT2B ASS1 ADH1C HEL-S-117 FZD10 PMC6518377__F1 The old dog POMC AgRP MC4R PMC4449096__F1 Signaling pathways through which macrophages regulate Beta-cell replication EGF SMAD2 EGFR PMC2697617__F1 Live Longer Sans the AT1A Receptor EGF EGFR GRB2 ARHA MTOR IRS1 ADAM17 PMC3142910__F5 Schematic representation showing proposed role of TMPRSS6 regulation by the BMP6-SMAD signaling pathway and iron via ID1 BMP6 SMAD4 TMPRSS6 HFE ID1 SMAD1 DKFZp781O1323 PMC3280674__F1 Fatty Heart, Cardiac Damage, and Inflammation APOB LPL TG CD36 PMC5149523__F3 PD-1/PD-L1 blockade enhances tumor rejection by activating T cells LCK MTOR LAT PMC2694804__F2 Summary of the pathways transduced by the primary cilium PDGFRA PDGFA SHH SMO PMC5149523__F1 Effect of PD-1 on major signaling pathways and subsequent metabolic reprograming in T cells APC LCK PTEN MTOR LAT PMC2864762__F13 CFTR Depletion Results in Changes in Fatty Acid Composition and Promotes Lipogenesis in Intestinal Caco 2/15 Cells APOB TG RXRA PMC4851838__F1 Recurrent genetic alterations and targeted therapies under investigation in iCCA HEL-S-26 EGF EGFR CCND1 MTOR ROS1 FGFR2 CDK6 ARID1A BAP1 PMC10143509__F3 Involvement of p53 in activation of interferon genes, of interferon-stimulated genes, and in feedback loops regulating these processes IFIT3 CGAS IFIT2 GLIPR2 STAT2 IRF7 IRF9 PARP10 IRF3 MX1 STAT1 ISG15 INPP5D TYK2 JAK1 IFIH1 MAVS SOCS1 IFIT1 PMC8913072__F8 Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling GDF15 BCL2 COL2A1 MTOR SOX9 PMC6776190__F10 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs GSK3B RAB23 SMO GAS1 ZIC2 PMC9115561__F2 RNA Therapeutic Options to Manage Aberrant Signaling Pathways in Hepatocellular Carcinoma: Dream or Reality? ARL4C CCR2 BIRC5 CXCR4 EGFR MYC MDM2 CCL2 MTOR TERT PMC8436520__F1 Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa STAT1 ISG15 IRF8 STAT4 CD40 TYK2 JAK1 IL12RB1 PMC5210527__F4 Insulin signaling pathway is significantly enriched in human cycling genes (the hypergeometric test, p-value = 9.70E-7, E-ratio = 2.26) PDK2 GRB2 INS EIF4E MTOR FOXO1 ASL INSR CBL PMC8141194__F1 Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review ATG16L1 ATG3 MTOR DKFZp686F0183 PMC6196657__F1 Expression and regulation of hepcidin in brain cells BMP6 TLR4 HAMP MYD88 STAT3 PMC3404846__F1 Mechanism of the tandem DRA/N-Boc protection proposed in this study based on the known pathway TH BOC PMC5216829__F1 Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer PIGF KIT RET PTEN MTOR PMC5594543__F4 Influence of PM10 exposure on coagulation CPB2 PC PLG F2 PMC9133800__F3 Biological nitrogen fixation and prospects for ecological intensification in cereal-based cropping systems MYC NPL PMC4985183__F6 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer PML NCOR1 CHAF1A MYC CHD4 RB1 TFDP1 ATM SNW1 CDC2 EZH2 PRKDC RBL2 NCOR2 RPA1 APC NUP214 PARP1 MCM7 CREBBP CDK2 TRIM28 RPS3 TF ARID4A PMC4985183__F5 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer PML EGFR MYC RB1 TFDP1 DMD CHEK2 XRCC5 POLE ATM POU2F1 SNW1 CDC2 EZH2 PRKDC RBL2 NCOR2 MYBL2 PRKAA2 RPA1 APC NUP214 MAP3K5 MCM7 RAD9A CREBBP TSC1 CDK2 TRIM28 TF ARID4A PMC3774688__F1 Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis NAMPT MARCKS TNFRSF14 LRRK2 FCRLA ADD2 CXCL2 TRIB2 HEL110 CCL2 CRK PTPRC GAB2 CD2 SRC PTPRE CD40 MCL1 BNIP3 COMP MEFV LAT ACTR2 PMC4985183__F3 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer CHAF1A RPS6KA4 MYC MAPK14 EIF2AK2 CHD4 RB1 XRCC5 POLE SNW1 EZH2 RAD21 APC MDC1 NUP214 XPC MCM7 RPN1 TSC1 MCM6 MCM2 SUV39H1 PML EGFR SNAPC4 LATS1 STK39 HSF1 WRN DMD ATM POU2F1 PTPN11 CCND1 CDC2 NIPBL PRKDC MYBL2 CBX3 PRKAA2 RPA1 FKBP5 PARP1 NEK3 CREBBP PELP1 ZCCHC8 PIAS1 TRIM28 TRIM24 REL ARID4A SUPT16H PMC8524440__F2 Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives CD80 CTLA4 PMC8145606__F11 Anti-Tumor Effect and Mechanism of Triterpenoids in Rhus chinensis Mill. on Reversing Effector CD8+ T-cells Dysfunction by Targeting Glycolysis Pathways in Colorectal Cancer SCAI APC MTOR HEL-S-133P IFNG PMC6691976__F1 Metabolic pathways regulated during T cell differentiation MYC TRAF6 FABP5 LPA HEL-S-104 HEL-S-133P RHEB HMGCR FASN PMC5541251__F6 Illustration of AHR activity in pituitary cells AIP AHRR AHR CDKN1A CDKN1B CYP1A1 TF PMC5806108__F3 Upstream cell signaling pathway of autophagy TSC2 TSC1 PTEN MTOR RHEB PMC7886651__F1 Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms STAT1 IRF4 GATA3 IFNG BCL6 STAT3 FOXP3 PMC5806108__F1 NSAIDs significantly induce autophagy HGF ATG12 MTOR DKFZp686F0183 PMC7139730__F3 The autophagy-induced anti-HCC polyphenols signaling pathways ULK1 ATG14 PMC3114309__F1 The NFAT structure SP2 SP1 SP3 TF PMC7139730__F1 Major cell death pathways: Apoptosis, autophagy, and necroptosis ATG12 TRADD APAF1 RIPK3 TNF FADD MLKL PMC3613096__F2 Signalling pathways involved in airway smooth muscle contraction NOX4 ARHA PMC7493323__F1 CX3CR1/ Fractalkine signalling—different roles in Microglia: In Alzheimer’s disease, chronic neuroinflammation increases the pro-inflammatory stimuli such as LPS, TNFA and IL-6 in the CNS PTMS CX3CR1 REST PMC4515126__F1 Sirt1 controls the immune responses in macrophages NAMPT SIRT6 SIRT1 PMC9535406__F5 Role of TGFΒ and autophagy in early crebellum development CDH8 SMAD2 SMAD4 CDH2 NCAM1 PMC8347150__F3 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes NFX1 RHO MTOR PMC8347150__F2 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes HEL-S-26 F2 HEL-S-133P FASN HEL-S-162eP PMC7642368__F5 Airway neutrophils are activated in intubated children with compared to children without PARDS MPO CD63 S1PR3 PMC3726753__F2 Morphoproteomic Profiling of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Desmoplastic Small Round Cell Tumor (EWS/WT1), Ewing’s Sarcoma (EWS/FLI1) and Wilms’ Tumor(WT1) TSC2 FLI1 RICTOR TSC1 IGF1R EGFR GRB2 PTEN WT1 MTOR RHEB MLST8 PMC3039931__F1 Cytoplasmic tyrosine kinases in the activating signaling pathways utilizing ITAM-containing adapters TEC SYK RHO PMC8743650__F1 Mitochondrial dynamics and diabetic kidney disease: Missing pieces for the puzzle of therapeutic approaches MFN1 PINK1 MFN2 MFF ROCK1 MIOX PMC4301880__F1 Experimental design PIGU PIGF PIGT PIGO PGAP2 PIGW PIGX PIGS PIGV PIGK MPDU1 PIGN DPM2 DPM3 DPM1 GPAA1 PIGH PIGM PIGA PIGP PIGL PMC3039931__F3 Inhibitory pathways in innate cells utilizing ITIM or “inhibitory” ITAM signaling pathways SIRPA NASP TEC SYK RHO PMC5275769__F4 miRNAs enriched with OSCC target mRNAs of the neurotrophin signaling pathway TNFSF6 BRAF RELA SHE ARHA BDNF CRK JUN BAX PMC4671616__F7 TGFB Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth SMAD2 DROSHA ARHA SMURF1 PMC3039931__F2 Tyrosine kinase pathways leading to CARD9 and TLR signaling responses CARD9 TEC SYK MYD88 PMC7161517__F3 Renin-Angiotensin System Interaction With COVID-19Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors ACE2 PMC7950759__F3 Smurf ubiquitin ligase activity and protein levels in cancers PRMT1 LCK TRAF4 PMC6330595__F1 Graphical representation of glutamine/2-HG pathway and therapeutics options in renal cancer based on Shelar et al HEL-S-26 D2HGDH L2HGDH PMC6611700__F1 Outside-in and inside-out signal transduction in myofibroblastic activation ARHA TNLG7C PMC10143579__F1 Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD HEL-S-90n KYNU KMO PMC3769666__F1 Extrinsic and intrinsic apoptotic pathways TRADD BAX PMC3382265__F1 Molecular network of protein degradation, amino acid metabolism, and behavior for NC-treated cells in comparison with TC extract-treated cells IFIT2 TUBB HEL-S-99n SHROOM2 SCARF2 GCG CRKL PS1TP5BP1 HEL-S-125m GAB2 BIN1 GRB2 CORO1B TUBA1B DOCK2 YWHAG CP PMC7234984__F1 Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures PPP1R3A PLCL1 CDK5 CSNK1G2 PPP2R3A PMC5819875__F2 Wnt/Beta-catenin signaling during early vertebrate neural development APC TEF MYC LRP5 LRP6 PORCN SP5 PMC6857659__F1 TGFB signaling pathway and its role in tumor immune microenvironment SMAD2 MYD88 CCL22 ID1 FOXP3 PMC1885790__F3 Diagram illustrating how the Rb and p53 pathways are linked to form a complex tumor suppressor network MYC MDM2 CDK4 BAX PMC11125669__F1 Pattern recognition receptors (PRRs) involved in intracellular viral sensing and downstream signaling TBK1 STAT1 CGAS TLR7 TLR9 STAT2 IRF7 IRF9 IRF3 MYD88 MAVS PMC2993245__F2 Negative regulation of junctional stability in RPE by the PI3K–ROS circuit EGF EGFR SRC PTEN PMC6681176__F1 Immunometabolism in atherosclerosis NLRP3 TNF IL1B IFNG PMC6051466__F2 Low antiviral gene expressions at the time of antiretroviral therapy (ART) initiation in cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) group IFIT3 IFIT2 DHX58 IRF7 EIF2AK2 CCL5 IFNB1 IFIT5 MX1 IFI44 ISG15 OASL OAS1 OAS2 OAS3 TLR7 IFIH1 IFIT1 PMC9549294__F5 Interleukin-1 receptor associated kinase 1 (IRAK1) is epigenetically activated in luminal epithelial cells in prostate cancer RUNX2 ETV7 HAL ETV6 MYC ETV4 ZNF708 ZFP14 ZFP57 ZNF667 EWSR1 ZNF343 ZNF189 STAT1 ZNF417 ZNF416 ZNF317 ZNF257 ZNF354C PAX5 ZNF454 ZNF530 ZNF135 SMO ETS2 SP1 JUN TMPRSS2 ZNF331 CREB3L4 FLI1 TCF3 FOS ERG ZNF701 KLF3 CREB3 ZNF816 NFKB2 ETV5 ZNF549 PMC9282724__F3 Models of autophagy dysfunction in neurodegenerative diseases TBK1 VPS35 SNCA LRRK2 PLA2G6 OPTN PLD3 GRN FUS PINK1 UBQLN2 SYNJ1 HEL-S-67p PARK2 FIG4 CHMP2B C9orf72 PICALM VCP CD2AP CPD PMC4069269__F1 IL-18 signaling NLRP3 IL16 SIGIRR TRAF6 PTEN MYD88 IL18BP IRF-1 GATA4 PMC6198264__F3 Pathway of biosynthesis and metabolism of testosterone, primary estrogens and progesterone during pregnancy STS HSD3B1 HSD17B1 CYP1A1 CYP17A1 CYP3A7 PMC8024309__F8 LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation ELAVL1 SQSTM1 GC PTEN MTOR PMC8549280__F1 SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous MVD MVK IPP PMC11674137__F1 DOX-induced cardiotoxicity in cardiomyocytes HMGB1 TLR9 ERBB2 STAT3 PMC11767473__F1 Importance of mesenchymal stem cells (MSC) in the bone-formation mechanism BMP6 RUNX1 RUNX2 ATF4 MSC STAB2 HOXA2 WNT10B SIRT1 FOXO1 PMC7977035__F1 Postlanosterol cholesterol biosynthesis pathway DHCR7 EBP SC5D DHCR24 DES PMC5889750__F5 Platyfish significantly down modulate the IGF signaling pathway leading to a suppression of cell proliferation, cell growth and cell survival in skin following FL exposure BAD IGF1 GRB2 JAK1 GRB10 PXN NEDD4 STAT3 PMC3047613__F2 Model: The kinase IKK may activate Htt degradation by a mammalian version of the yeast Cvt pathway HTT CDK5 SIRT1 RHEB PMC11674137__F2 Landscape of the mitophagy mechanisms TBK1 PINK1 ULK1 FUNDC1 MUL1 OPTN SMURF1 PMC5889750__F9 Platyfish skin (A) significantly down modulates the PPARA/RXRA signaling pathway in response to FL; however, both medaka (B) and zebrafish (C) significantly up-modulate the PPARA/RXRA pathway in skin following FL exposure NR0B2 TRAF6 JUN PMC5889750__F8 The telomerase signaling pathway is oppositely modulated in platyfish (A) compared to medaka (B) and zebrafish (C) following FL exposure SHE TERT PMC5889750__F7 In zebrafish following FL exposure, the most significantly modulated pathway in skin is the oncostatin M pathway MMP3 MT2A GRB2 OSM PMC5889750__F6 Acute phase signaling pathway in fish HRG PLAA CFB TRADD HP ECSIT MTOR PMC5397662__F2 A simplified diagram showing the major steps in short-patch base excision repair pathway PMC9575659__F9 Comparative physiological, transcriptomic, and WGCNA analyses reveal the key genes and regulatory pathways associated with drought tolerance in Tartary buckwheat HSF4 HSF2 PMC3439829__F4 Diverse cohesinopathy phenotypes MAU2 ESCO1 HDAC8 PDS5B WAPAL PDS5A ESCO2 NIPBL PMC4724579__F2 Toll-like receptor 2’s signalling pathways contributing to hepatocarcinoma HMGB1 PMC4724579__F5 Toll-like receptor 9’s signalling pathways influencing hepatocarcinoma HMGB1 TLR9 PMC8366499__F1 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis GRB2 SHE ABCG2 PMC4724579__F4 Toll-like receptor 4’s signalling pathways influencing hepatocarcinogenesis HMGB1 TLR4 PMC3121779__F15 Protective effects of OxPLs against acute lung injury and endothelial barrier dysfunction CD14 LBP HEL164 RHO CDC42 PMC6856358__F8 Proposed signaling pathway of this study IGF2BP1 IGF2 EGFR MYC MTOR MAGEA6 PMC5415275__F9 The putative role of central insulin resistance in attenuating leptin modulation of rHypoE-19 hypothalamic neurons SOCS3 FOXO1 STAT3 PMC2937585__F1 Folate metabolic pathway DHFR PMC7720011__F3 Possible relation of prostate cancer to viral pathogenesis PIM1 ERG ZEB2 HEL-S-97n SPINT1 PARP1 ACE2 PRDX3 PMC10179893__F5 PS inhibits macrophage M2 polarization via IL-4/STAT6 signaling pathway, and in turn suppresses TAM-induced tumor progression ARG1 PMC7720011__F1 Functional pathway of androgens and its receptor ERG PTEN TGFB1 TMPRSS2 PMC4394497__F11 Findings from our laboratory using an animal model of the autoimmune disease, RA, reveal disease-related changes in B2-AR signaling that are dependent upon the lymphoid tissue examined ADRBK1 PMC10534981__F1 Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy HPDL HES1 PMC5851248__F5 Summary of excitotoxic pathways, mediators and potential therapeutics PTEN PANX1 PMC3884689__F7 Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery SMAD2 HSPA2 TGFBR1 MAPK14 RPS7 SNRPA DNMT3B UBE2V1 RIPK1 DICER1 SH3BP4 APAF1 ATF4 HGS SRPK1 MAPK1 OGDH EZH2 ACTN4 RHOB HNRNPR RUNX1 NONO DROSHA ATF3 HDAC1 BRCA1 RXRA HEL-S-22 ADAR PITPNM2 NDUFB7 RBBP7 RAF1 SMAD1 PMC6659691__F3 Interferon-gamma (IFNG) pathway and its modeled representation to demonstrate the step-by-step calculations for protein-protein interactions at each node in this pathway and as an annexure section of other pathways CXCL1 CHUK MYC IFNGR2 CCL2 KIN IL12A CCND2 IFNG STAT1 FYN HEL-S-11 IL17A CCND1 CD40LG IFNGR1 VEGFA IL8RB CXCL2 CCL4 IRS1 IKBKB RS1 IL15 GAB2 NFKB1 CXCR4 CXCL9 CD40 CD80 JAK1 MCL1 CD36 PMC6659691__F2 A modeled signaling pathway using a G Protein Coupled Receptor activation as an example GNAS OTP PMC12137166__F1 CA PD-OTC of CZ019 displays enhanced glycolysis and noncanonical Krebs cycle metabolism HEL-S-62p ME1 GOT2 HEL-S-30 OTC HEL-S-32 GLS PMC5312414__F1 Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway TSC2 PTEN MTOR RHEB PMC2556249__F2 Insulin receptor signaling PI3 GRB2 IRS1 PMC6659691__F1 Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer IL10 IL13 CXCL10 VEGFA IFNGR2 TNF IFNG IL18 TLR4 CCL20 IL22 IL2 CD40 CD40LG CD80 IL4 CSF2 PMC5478692__F1 Schematic overview of Imd pathway in Drosophila melanogaster CYLD RHD FADD PMC8221540__F8 Immunometabolic Endothelial Phenotypes F2 PDK4 FOXO1 PMC3928701__F1 Normal signaling pathways and alterations in aged DCs in response to lipopolysaccharide (LPS)/bacteria (A), and in response to self antigen (DNA) IRF3 IL6 MYD88 PMC5773512__F6 Schematic to illustrate calcimimetic R-467 reversed Cd-induced signaling pathways, followed reinstated intracellular Ca2+ level and ROS generation, restored autophagic flux, alleviated cell apoptosis and stimulated cell proliferation CASR NPS CD2 PMC5609950__F9 Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma LEFTY1 BCL2 BAX PMC5354695__F1 Long noncoding RNAs in head and neck cancer FOXC1 TSHR VEGFA PTEN EZH2 DNMT3B CDK6 PMC9433211__F2 Ferroptosis and Its Relationships with Other Types of Programmed Cell Death: Insights for Potential Therapeutic Benefits in Traumatic Brain Injury CYLD SI PMC10526262__F2 Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets METTL3 LGALS3BP GSK3B MTOR CHI3L1 PMC3377006__F1 Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression FOXP3 PMC10243706__F1 Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies TLR5 TLR4 IRAK1 SIGIRR MYD88 STAT3 PMC8535782__F1 Control of ovarian follicle development by TGFB family signaling KIT GREM1 BMP2 BMP15 GREM2 BMP4 PMC4945497__F1 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A IRF9 MTOR PMC11622655__F1 Effect of Triolein on brain damage after ischemic stroke IL10 IL6 MTOR PMC4945497__F2 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A CD14 NLK EGF MOS DAO MAX FRK FLNA EGFR TRAF6 RAF1 TRAF2 PMC9453879__F7 Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARA pathway in diabetic rats UBC PLTP PC UCP1 HEL-S-28 ACP7 LPL PMC6986448__F3 KISS1 in breast cancer progression and autophagy MMP24 FOS MMP9 PRL MED23 MMP3 MMP14 IGF1 MMP2 NPY NFKB1 RELA SND1 RABEP2 TFAP2A SP1 SP3 GNRH1 PMC6176931__F3 Multiple phases and regulation of cilium assembly RAB8A EHD1 MARK4 KCTD17 NDEL1 INPP5E PMC10873884__F3 Different self-incompatibility systems FER PGAP1 MAPK9 GLO1 ROS1 PMC6804657__F1 Autophagy induced via cGAS-STING and its signaling pathway CGAS SEC24C WIPI2 AMN PMC7915848__F4A Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers? C4BPB HSP90AB1 TNFAIP6 EGFR SAA1 NRP2 C9 FAM20A OMD RPS27A opn B4GALT2 CRP APP JUN RPS15A GANAB VCAN VEGFA NCAM1 ITGB1 PTX3 HEL-S-125m TNC VTN LBP STAT3 PMC9657932__F6 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside FES HEL-S-162eP PMC11354614__F2 Glucose and stress metabolism HSP90AB1 CA8 ANXA9 CA14 CA13 HEL-S-101 GPX1 CA3 NNT CA11 ANXA6 PFKM PRDX3 PYGM HEL55 GLO1 HEL-S-67p HEL-S-44 CAND2 PRDX5 ANXA10 DDT CA4 CA7 HEL-S-133P PGAM2 HEL-S-281 ENO3 ANXA11 HEL-S-30 ENO1 GYS1 CA9 HEL-S-87p HEL-S-162eP HEL-S-68p HEL-S-102 HEL-S-49 CA12 HEL-S-72p TRIM72 AGL PMC10531451__F6 Heatmap of DEPs participated in the mevalonate (MEV) and methylerythritol phosphate (MEP) pathways of terpenoid biosynthesis MVD IPP PMC6442683__F4 Dendritic structural plasticity and neuropsychiatric disease EEF2K EEF2 ARHA MTOR BDNF TARP TRIO PMC1440856__F1 Omega-6 and -3 fatty acids & Prostate Cancer COX2 ALOX15B ALOX15 GLA PMC6442683__F3 Dendritic structural plasticity and neuropsychiatric disease DLGAP1 CASK SHANK3 PRRT2 RAC1 CACNB4 SYNGAP1 PSD DLG4 CACNA1C NF1 CACNG2 KALRN NLGN3 NRXN1 CAMK2A TRIO PMC8799442__F1 Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients PIR ADA TRPM2 PANX1 PMC9271571__F1 NFKB Inducing Kinase Regulates Intestinal Immunity and Homeostasis RELA TRAF3 RELB REL TRAF2 PMC8295173__F1 T cell metabolism drives T cell fate and function in to eliminate tumors APC CD80 CTLA4 ARG1 PMC7653700__F3 T cell senescence-related signaling pathways STAT1 CGAS ATM LCK ZAP70 MTOR MAP3K7IP1 GATA4 TERT STAT3 PMC4646736__F2 Proposed pathway of prostaglandin synthesis and interaction with the cyclooxygenase pathways and VEGFA COX2 COX1 VEGFA PMC8042281__F1 Pre-existing chromatin features and damage-induced histone modifications regulate the DNA repair pathways ME1 ME2 KDM4D KDM3A SETMAR HDAC1 tal-1 KDM5A KDM5C KDM4B KDM2A EZH2 SETD8 ME3 H2AX KMT5C KDM4A KMT5B KDM6B PMC8042281__F3 Histone modifications, dynamically added or removed around the DNA damage site, constitute an integrated signal for the DSBs repair pathway choice ME1 PALB2 ME2 SETMAR MBTD1 BARD1 HDAC1 BRCA1 L3MBTL1 RNF168 PRC1 RNF8 HDAC2 RAD51 KDM2A VCP SETD8 ME3 H2AX KMT5C KDM4A KMT5B PMC4131284__F6 CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110 PML ATM BRCA1 PMC5485420__F10 Graphical representation for Mel regulation in DRG neurons ME1 CACNA1B MAPK1 RORA IL1B PMC5336175__F10 Differential phosphorylation of YBX1 on Ser-176 and Ser-165 and their role in NFKB activation YBX1 CTRL IL1B PMC8540409__F6A Metabolomics Investigation of the Metabolic Changes of Raji B Lymphoma Cells Undergoing Apoptosis Induced by Zinc Ions PLCG1 LYPLA1 PC EGFR GRB2 GPCPD1 PMC7072361__F1 Potential role of podocalyxin (PODXL) in mature B-cell non-Hodgkin lymphoma (B-NHL) progression CXCL12 NHERF1 FASN PMC9306053__F3 Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review MFN1 MFN2 FOXO1 OPA1 PMC4540474__F6 HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation RNF8 MAP3K7IP1 TAB3 PMC4959441__F1 RAS-mediated signal transduction pathways and post-translational modification of RAS RCE1 EGFR RALA RALB MTOR COCH PMC7396046__F2 Suggested signaling pathway for glucose-induced increase in glucagon synthesis, glucagon secretion, and alpha cell proliferation EGFR SRC MTOR PMC9657932__F2 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside EGFR GRB2 PTEN PMC8197596__F1 Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again? MMP14 RELA NOTCH1 LZTFL1 ACE2 SIRT1 APOE PMC7504526__F4 mtDNA-triggered cGAS-YAP pathway TBK1 CGAS YAP1 LATS1 PMC6910929__F3 Regulation of PI3K/AKT signaling pathways BAD PTEN PMC12012199__F7 Targeted demethylation of EphA7 inhibits tumorigenesis via the SP1/DNMT1 & PI3K/AKT axis and improves the response to multiple therapies in cervical cancer EFNA5 EPHA7 SP1 PMC7313447__F7 Astragaloside IV attenuates high glucose-induced EMT by inhibiting the TGFB/Smad pathway in renal proximal tubular epithelial cells SMAD2 CDH2 PMC5265847__F3 TP53-centered protein–protein interaction network identified based on the Level 2 gene set using Ingenuity Pathway Analysis TP53BP2 CD133 KLF5 CHMP4C DACH1 NOX4 RGS13 NOTCH3 SOX4 TNFRSF9 TNFSF6 BTG1 IL2RA LPP PTPN6 PYHIN1 OSM F11R PMC7419982__F5 Sodium (Na+) and potassium (K+) ion homeostasis by SOS pathway SOS2 SOS1 PMC6627931__F1 Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation TLR4 IL33 LTB MYD88 PMC4700430__F2 Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses HEL-S-11 ACR PMC4037924__F1 Ancestral Ca2+ Signaling Machinery in Early Animal and Fungal Evolution MID1 HEL-S-11 LETM1 MICA PMC7699248__F2 Wnt/Beta-catenin signaling pathway represses VDR expression NR1i1 PMC7699248__F1 Mechanisms by which 1,25(OH)2D3 interferes the Wnt/Beta-catenin signaling pathway in human CRC cells NR1i1 GSK3B AXIN1 CCND1 TCF7L2 DKK1 IL1B TCF4 PMC6857441__F7 Schematic overview of the pathways linking glucocorticoids and their precursors to their urine metabolites HSD11B2 HSD11B1 CYP21A2 PMC2681001__F1 Biosynthetic Pathway of Coenzyme Q10 COQ3 COQ10B COQ2 COQ10A COQ9 COQ6 PDSS1 COA7 COA5 PMC6857441__F3 Schematic overview of androgen biosynthesis PAPSS2 HSD11B2 SULT2A1 HSD11B1 HSD3B2 HSD17B2 POR AKR1C2 CYP17A1 FDXR PMC8273916__F8 Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor Alpha-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway GPR78 ATF4 PMC7552065__F2 HBV infection pathway SHB LHB PMC4335176__F2 Pathways leading to stimulation of extracellular-regulated kinase (ERK) and AKT phosphorylation by fluoxetine in astrocytes EGF EGFR HBEGF PMC7397420__F12 Demonstration of the putative mechanism of action of lithium in the NFKB signalling pathway BTRC IRAK1 TRAF6 AK4 TIRAP PMC3570922__F1 PI3K/AKT/GSK3/mTOR signaling PTEN MTOR PMC8745344__F8A Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure AKAP12 HEL-S-99n CPT2 RYR2 SIRT3 HEL-S-5 PLN LETM1 SLC27A1 ADCY5 CASQ2 GAL PLCD3 PMC8876702__F2 Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies DNER RBPJ PIEZO1 ARHA MTOR PMC7916890__F3 Crosstalk between mTOR signaling and PI3K/Akt pathway PTEN GRB10 IRS1 RHEB PMC7916890__F2 Amino acids and growth factors-mediated activation of the mTORC1 signaling NPRL2 FLCN C16orf35 SLC38A9 WDR59 MIOS WDR24 SZT2 RHEB PMC8283590__F2 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update SRC CXCL2 PMC8283590__F1 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update APC GSK3B LRP5 LRP6 PMC2192627__F1 Signaling mechanisms involved in lifespan regulation and the cellular response to genotoxic stress TSC2 TSC1 IGF1R IGF1 ATM MTOR IRS1 SIRT1 PMC8283590__F3 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update BTRC AMOT NF2 LATS1 LATS2 TCF4 PMC10941343__F9 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach TRPV4 SHE APP CNP ARHA KLF2 TNF BMP4 PMC8432043__F1 Exploring the pathways to chronic lymphocytic leukemia PTCH2 CCL21 CCR4 CD44 CXCR5 CCL4 CCL1 ROR1 CCR1 CXCL13 VCAM1 PTCH1 CXCR4 CCR7 CD40 SMO CCL19 CXCL12 CCL3 PMC8269276__F1 Promising Treatment Options for Axial Spondyloarthritis: An Overview of Experimental Pharmacological Agents EPO TPO JAK3 JAK1 IFNG PMC4591212__F1 Altered modulation of the IL-8 signaling pathway in AH livers with MDBs LIMK2 GNG2 GNG11 GNAI1 BAX PMC11997178__F5 TRAF2 roles in cancer CAP2 CAP1 MTOR TRAF2 ROR1 FZD5 PMC7478739__F6 SOAT1 abrogates cholesterol feedback inhibition to promote mevalonate pathway dependency in PDAC LDLR SOAT1 RHO HMGCR PMC11997178__F2 TRAF2 role in the TNFR1 and TNFR2 signaling pathways STAT1 RIPK1 TRADD RIPK3 BMX TRAF2 FADD TAB3 PMC11997178__F3 TRAF2 role in the canonical and noncanonical Wnt signaling pathways TNIK TRAF2 ROR1 TCF4 PMC5013308__F5 Pathway map of quantitative comparisons of metabolic proteins in RKO cell lines CS DERA SHMT1 PFKM HEL-S-32 GOT2 SI FH ACO2 PAICS HEL-S-70p SUCLG2 RPE DLAT SDHB FASN ALDOB HK3 PFAS ENO1 DLD PFKL HEL-S-87p HEL60 HEL-S-162eP HEL-S-68p PSPH HEL-S-51e ACLY HEL107 ASL PMC5013308__F4 Pathway map of quantitative comparisons of metabolic proteins in DLD-1 cell lines CS DERA SHMT1 PFKM HEL-S-32 MDH2 HEL-S-26 GOT2 FH ACO2 HEL-S-304 PAICS HEL-S-70p SUCLG2 RPE DLAT PGAM1 HEL-S-133P HK2 HEL-S-281 SDHB FASN ALDOB HK3 PFAS ENO1 DLD PFKL HEL-S-87p PHGDH HEL60 HEL-S-162eP HEL-S-68p PSAT1 PSPH HEL-S-51e ACLY HEL107 ASL GLUD1 GLS PMC2865574__F3 Wnt signaling is a complex pathway, believed to be involved in the regulation of divergent processes, including the maintenance of pluripotency and commitment to differentiation CCND1 AXIN2 S100A4 PMC9604538__F2 Pathways for ATG16L1-mediated conjugation of LC3 to membranes during autophagy and LAP/CASM conjugation via the V-ATPase-ATG16L1 axis ATG16L1 ATG12 ATG3 WIPI2 UVRAG ATG14 DKFZp686F0183 PMC11186359__F8 Schematic diagram showing how PM increases AREG-dependent glutamine metabolism and lung cancer proliferation AREG EGFR MTOR PMC5716183__F1 One-carbon metabolism, transmethylation reactions and DNA demethylation HEL-S-61p GADD45B MTR PMC3175556__F7 Schematic diagrams of the signal transduction in TCDD-induced MUC5AC gene expression and the conventional AhR pathway in the activation of CYP1A1 expression AHR EGFR SP1 PMC5215528__F1 ARE gene product interactome EGF MYC CXCL8 CXCL3 CCL2 FGF9 CCNE1 IL16 MMP2 BIRC3 CCND1 NOS2 CSF2 JUN IL1B IL10 FOS PTGS2 FGF2 MMP9 VEGFA CXCL2 EIF4E IL6 TNF PTHLH VCAM1 IL3 CDK2 BCL2 CXCL12 CSF1 TGFB1 CCL3 PMC8001969__F4 MTOR signaling pathway and its important regulatory functions are shown TTI1 ULK1 TSC1 TFEB DEPTOR IRS1 SGK1 RHEB PMC9214030__F2 From a Hetero- to a Methylotrophic Lifestyle: Flash Back on the Engineering Strategies to Create Synthetic Methanol-User Strains LTA HAL GPT HEL107 RPE MTHFS PMC7521558__F7 Schematic model summarizing the effects and signaling pathway of SRA in RCC SOX2 CD44 CCND1 CDK4 ABCG2 CDH2 CDK6 CD24 PMC2793058__F10 IFNG signaling pathway in retinal pigment epithelium STAT1 JAK1 CFTR PMC7747940__F2 Porphyromonas gingivalis: Immune subversion activities and role in periodontal dysbiosis CXCR4 MYD88 TLR1 TIRAP PMC8927572__F3 Proposed precision treatment strategies for MAPK pathway-mutated head and neck cancer BRAF ERBB3 EGFR MAPK1 HRAS PMC8927572__F2 Components of the MAPK pathway are mutated in both HNSCC (at somatic level) and in various RASopathies at germline level NF1 DUSP5 DUSP9 GRB2 SPRED1 DUSP3 DUSP7 PMC5861627__F3 Crosstalk between Shh pathway and others EGF KIT BAD KIF7 GHB2 BRAF TGFBR1 EGFR APC GSK3B LRP5 TGFBR2 LRP6 PTEN MTOR SUFU SHH PIK3CA SMO OTOR PMC5861627__F1 Canonical activation of Shh pathway in vertebrates KIT SMO PMC8262573__F1 Translational Control is an Emerging Mechanism of Programmed Cell Death Ligand 1 (PD-L1)/Programmed Cell Death Protein 1 (PD-1) Regulation in Cancer STAT1 EIF5B EIF2A MYC IFNG PMC8761741__F2 Criminal of Adverse Pregnant Outcomes: A Perspective From Thyroid Hormone Disturbance Caused by SARS-CoV-2 TH TRH TG IL1B PMC6771534__F2 Evasion of the IFN‐I signaling pathway by HSV1 TBK1 CGAS TLR9 IRF3 TLR3 PMC9367940__F9 Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca2+, cAMP and ACh TRPM5 CFTR PMC2761115__F2 Gonad function and sexual differentiation DHH EMX2 LHX9 WT1 SOX9 FGF9 SRY FST RSPO1 AMH WNT4 SF1 INHBB PMC11662631__F8 Schematic show that the mechanism of hsa_circ_100791 promote the progression of allergic rhinitis TRIM13 IL33 IL2 IL4 TNF CAPRIN1 PMC4016907__F5 Both images were created using IPA MAPKAPK2 CHUK GSK3B GSK3A PTEN PDK4 AURKB RHEB PRKCA IKBKB CHEK2 RPS6KB1 PRKCB CAMK4 MDM2 NEK2 PRKDC SGK1 AKT3 PMC12000036__F2 Functions of TREM2 DOK3 STAT1 ACAT1 SMAD2 ADFP GRB2 SRC MYD88 ABCA1 SOS1 MTOR PMC4874901__F8 JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src DOK4 SRC TNF PMC8614257__F8 Equine Endometrosis Pathological Features: Are They Dependent on NFKB Signaling Pathway? RELA IL6 CSA2 HAS2 PMC12000036__F1 TREM2 signaling pathway DOK3 CD33 SRC SYK PLCG2 ADAM10 MTOR ADAM17 PMC1420312__F5 Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways FBN2 BOP1 WNT7A ANXA4 DKK1 SPN WT1 SOX7 AK2 MMP3 COX2 MMP7 OAS1 JUP GBP2 TLE4 SHH FZD7 SMO NOTCH2 CLDN1 APC TSPAN7 CD44 HDAC1 ANGPT1 LEF1 GIG8 PSAT1 GLG1 WNT5B BCL9 PMC7492727__F4 Proposed pathological mechanisms of MuSK autoantibodies at the NMJ MUSK ACHE ACR PMC8092973__F1 Simplified schematics of the mechanisms of replication fork restart upon replication stress REV1 PALB2 FANCD2 SETD1A CHD4 ZRANB3 RADX PRIMPOL SMARCAL1 RAD52 RAD51 HROB POLI RAD51C MCM9 FBXO18 POLK WRNIP1 SLX4 BARD1 PARP1 MCM7 POLN MRE11A BRCA1 POLD3 CDC45 MCM3 MCM5 MCM6 MCM2 BRCA2 HLTF FANCA PCNA PMC8840702__F1 Ferroptosis in cancer therapy: a novel approach to reversing drug resistance GPX4 LPCAT3 FACL4 LCN2 HEL-75 KIF20A ATF3 POR ARF6 PMC4488672__F5 Hierarchical signaling pathway expression regulates regeneration LEF1 IHH WNT3A SHH PMC10950698__F9 IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11 IL13RA1 SLC7A11 SLC3A2 SOCS1 PMC9605170__F4 Incorporation of Suppression of Tumorigenicity 2 into Random Survival Forests for Enhancing Prediction of Short-Term Prognosis in Community-ACQUIRED Pneumonia IRAK1 IL33 MYD88 TRAF4 PMC7920043__F1 Schema of “signaling” pathways for CS effects SMAD2 EGFR SMAD4 DKFZp781O1323 PMC4521272__F1 Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response TLR7 IFNA4 IRF7 IRF3 IFNAR1 TLR3 PMC9604538__F5 Interactions between pathogens and LAP/CASM ATG16L1 ATG12 VAMP8 DKFZp686F0183 PMC8495264__F7 Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing PCDHA1 NR3C1 TRIM34 TCF7L2 DVL1 DCDC2 RICTOR GNA15 BCL2 NKAIN1 ATP6V1G3 NFIA ANGPTL7 FOXH1 PMC3706794__F8 Proposed mechanism demonstrating the interplay of heme oxygenase 1 (HO-1) and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cells (MSC)-derived adipocytes MSC GSK3B WNT10B CD36 PMC6580798__F3 Proposed pathway for metabolic detoxication of AAI CRP CYP1A1 CYP1A2 NQO1 PMC8227208__F4 p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies N4BP1 EGR1 YAP1 NGFR EGFR MDM2 SLU7 RPL26 CEBPA NQO1 ITCH PMC8623382__F1 Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites SPHK1 CERK SPHK2 SMS PMC6689986__F1 Autophagy in the differentiation/function of osteoclast, osteoblast and osteocyte BMP2 SMAD1 DKFZp686F0183 DKFZp781O1323 PMC7047114__F6 NFKB-pathway TLR4 IRAK1 TRAF6 IRAK4 MYD88 GLRX PMC8256831__F2 Adult Hippocampal Neurogenesis and Alzheimer's Disease: Novel Application of Mesenchymal Stem Cells and their Role in Hippocampal Neurogenesis IGF1 MSC BDNF PMC8631414__F5 Low-intensity extracorporeal shock wave therapy promotes recovery of sciatic nerve injury and the role of mechanical sensitive YAP/TAZ signaling pathway for nerve regeneration NGF GDNF BDNF PMC9074275__F6 Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway TSPAN7 SRC CDH2 PMC5329892__F3 WNK kinases in development and disease APC DCT OSR1 PMC9389066__F2 Pyroptosis and inflammasomes in diabetic wound healing NLRP3 GSDMC GSDMD DFNA5 PMC12073904__F7 Mechanistic model of inflammation, mitochondrial dysfunction, and neuromuscular junction characteristics of HF and LF octogenarians FGF21 F2R ANGPTL4 NADK NCAM2 CDH15 NMNAT1 GDF15 CXADR APP BDNF ADM NEFL AGRN PMC9389066__F1 Pyroptosis and inflammasomes in diabetic wound healing NLRP3 NLRP1 TNF AIM2 PMC3622708__F8 Wnt3a/Beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling program MSGN1 LFNG NOTCH1 HES7 PMC3871231__F2 New and emerging HDAC inhibitors for cancer treatment SAP18 TBL1XR1 HDAC3 TBL1X HDAC10 HDAC8 HDAC2 GPS2 HDAC1 SAP30 PMC8401922__F3 AMPK and Its Downstream Signals in Pain Regulation TSC2 ULK1 CSF1R CSF1 MLST8 PMC11352841__F2 Bioactive compounds targeting NFKB signaling pathway to prevent inflammatory changes and mastitis TLR4 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 TRAF2 PMC11352841__F1 Bacterial induced mastitis via activating TLR2/TLR4/NFKB signaling pathways in mammary gland cells TLR4 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 TRAF2 PMC3965010__F1 Example of disease curation and visualization in Reactome SLC37A1 CLC G6PC2 CIC PMC7339281__F2 METTL3 regulates cell proliferation LEF1 IGF2BP1 DGCR8 AFF4 METTL3 EGFR MYC PTEN ATAD2 PMC6316632__F1 Simple central carbon network of the Xanthomonas oryzae pv. oryzae BXO43 strain TAC3 CIT MAL PMC7396579__F3 Glucocorticoid resistance (GCR) in sepsis PCK1 TSC22D3 GC SPHK1 TF PMC11352841__F3 Probiotic targetingTLR2/TLR4 /NFKB signaling pathway to prevent inflammatory changes and mastitis TLR4 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 TRAF2 PMC4694690__F1 Clinical use of cobicistat as a pharmacoenhancer of human immunodeficiency virus therapy SLC47A2 SLC47A1 PGP ABCG2 SLC22A4 ABCC2 SLC22A5 SLC22A2 PMC5436210__F2 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma MAFB GADD45G RUNX1 ATG2B ACACA SMAD2 NR0B2 PURA SSB HBEGF CASP2 AQP4 KMT2C ITK CARD11 WEE1 SCD PPARGC1A MTDH RPS6 SOS1 SIRT1 FASN PMC7339281__F3 METTL3 regulates cell apoptosis METTL3 TFEB HNRNPD ZNF750 SHH FGF14 PMC9231174__F3 Calcifediol for Use in Treatment of Respiratory Disease TLR4 FGF23 HAMP MTOR NOD2 CYP27B1 IFNG PMC5436210__F3 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma PDE3B AGO2 SGCA DICER1 FOXO4 SCD INS TNFSF12 LMNA CIDEA MEF2C PMC4194559__F1 Presents an overview of the Rho/Rho-associated protein kinases signaling pathway ROCK2 MAP2 ROCK1 RHO CDC42 PMC2858867__F1 ALPS – Ten Lessons from an International Workshop on a Genetic Disease of Apoptosis CASP10 CASP8 FADD PMC11989906__F4 Adipose Tissue Metabolism in Naturally Grazing Sheep at Different Growth Stages: Insights from mRNA and miRNA Profiles SCD SLC2A4 ACACA PFKP FASN CAMKK2 PMC7338975__F1 Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease GCLM GPX4 LPCAT3 STEAP3 KEAP1 SLC7A11 GCLC FTH1 FTL DKFZp686F0183 HEL-S-102 HEL-S-64p ADA HEL-75 IREB2 PMC4140250__F1 Schematic view of the sphingolipid metabolism in S FEN1 ORM2 ORM1 PMC5415104__F9 Anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways TLR5 TLR4 MYD88 PMC5415376__F3 Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma C1QL3 CS PCK1 FBP1 GSK3A PDK4 MDH2 HEL-S-26 PDK3 ENO2 PCK2 PGAM2 HK2 PMC7011072__F3 Curated interactions for HES1, NOTCH1, and TNFA genes using SIGNOR database IKBKE RBPJ NR3C1 CREB1 NOTCH1 TNF PPARG PMC8969013__F1 STING1 in Different Organelles: Location Dictates Function TBK1 CGAS MITA IRF3 MAVS PMC5713689__F3 Signal pathway of the immune inhibitory receptors.Notes: PD-1 crosslinks the TCR and recruits the SHP-2, which can dephosphorylate the ZAP-70 to prevent the SLP-76 and LAT from being phosphorylated LCK ZAP70 TRAF6 PTEN TIGIT LAG3 MTOR LAT FOXP3 PMC7020470__F6 Schematic diagram depicting MetAP2 implication in different pathways BAD METAP2 MDM2 CDC42 PMC7513295__F4 PPI network analysis IKBKE CHUK HAVCR2 CD48 SAMSN1 TEC HLA-DQB1 TFRC SPN PAG1 SP100 CEACAM1 HLA-DMA BATF STAT1 OAS1 OAS2 TLR4 LILRB4 BIRC3 ULBP3 TXK ZNF155 ZNF223 UNC93B1 ZNF221 ZNF34 CTSH SLAMF7 IL23R CD79A PTPRC HLA-DPB1 LTA TNLG8A IL23A JAK3 SYK CD80 RORA TNFAIP3 HLA-DMB PYCARD GPR183 SASH3 PMC7056469__F4 Oxidative stress are targets of antioxidant dietary compounds VIT KEAP1 GCLC OGG1 PMC10876307__F5 Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells CA14 CA13 GRB2 CA11 ARHA CA9 CA12 PMC7355474__F8 Graphical representation to elaborate on the possible mechanism underlying antioxidative and anti-inflammatory potential of A3 against the p-MCAO-induced brain injury MAF TLR4 BCL2 PMC3974768__F8 Stem and Progenitor Cell Subsets Are Affected by JAK2 Signaling and Can Be Monitored by Flow Cytometry CD48 MPP2 MPP3 PMC12237660__F3 TREM2/TREM2+macrophages in MASH TLR4 IRAK1 TRAF6 SYK MYD88 PMC12237660__F2 Targeting TREM2 signal pathway SYK ADAM10 ADAM17 PMC12237660__F1 MASH (Metabolism and immune response) CCR2 PMC9006795__F1 Aneurysmal subarachnoid haemorrhage—cerebral vasospasm and prophylactic ibuprofen: a randomised controlled pilot trial protocol COX2 KY COX1 RHO PMC5118702__F5 Molecular and biological pathway interaction map analysis of altered proteins from the CCI samples (1 vs STXBP1 HEL-S-99n ENO1 PMC6943653__F1 Scheme of the insulin/IGF-1 signaling pathway (IIS) in C SGK1 PMC4007207__F9 Model of the role of an epidermal barrier defect in tumour protection RAE1 HRAS TSLP PMC6030864__F1 Pathway relationship network MTOR MAL PMC8234459__F3 Paradoxical Roles of Desmosomal Components in Head and Neck Cancer EGF KLK5 EGFR SNAI2 DSC2 MMP7 PKP1 DSG1 DSG2 PKP3 DSG3 CCND1 DSC1 ERBIN PMC7878744__F1 Renal metabolism and hypertension CS HEL-S-5 GLS PMC3026934__F2 Signaling pathway induced by Dectin-1 CARD9 BCL10 SRC SYK PMC7023692__F3 Representative diagram of circRNA mediated ceRNA network and oncogene signaling pathways DICER1 U2AF1 SHKBP1 FOXP2 FZD7 MOV10 ZIC4 TCF2 WNT7B ITCH STAT3 PMC3140958__F6 Protein interaction maps of the defined ratio clusters, (A) [G1_S]#3 and (B) [G1_S]#2 GGA2 FUS PMC4981436__F4 The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine RARA RARB NR1B3 NR1A2 PPARG NR1C1 RXRA THRA PMC3256462__F1 Basic signaling pathways and relevant targets together with their inhibitors associated with endocrine resistance Estrogen receptor alpha (ER) and the growth factors (esp EGF SRC ADAM17 PMC6369349__F1 Molecular signaling pathway of TNFR2 TRADD TRAF1 TRAF3 TNF MAP3K7IP1 TRAF2 FADD TAB3 PMC4713888__F1 Immune evasion mechanisms seen in acute leukemia.Multiple immune pathways and functions are targeted by acute leukemia MICA LAG3 STAT3 PMC3499976__F1 Wnt transduction pathways and their functions during synapse development, function and plasticity MAP2 MUSK MAP1B APC GSK3B RHO PSD PMC8678454__F7 Global Profiling of N-Glycoproteins and N-Glycans in the Diatom Phaeodactylum tricornutum TH ALG12 INS PMC8636065__F7 Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice GRM2 GRM3 MAPK3 SHANK3 GRIA3 GRIK1 GRIA4 GRM8 GRIA2 GLS PMC5814228__F6 Deciphering microRNA targets in pancreatic cancer using miRComb R package DTX3L HES5 NUMB EP300 DTX4 ADAM17 HES1 PMC6089339__F7 Summary of the location pattern of CFP (blue), YFP (yellow), neuronal (PV) and activity markers (Arc) in the hippocampus PC HEL-S-11 FH GC ARC CA3 CFP BDNF PMC5855671__F2 Integrins act as “double agents” during Helicobacter pylori infection in the stomach, serving to potentiate bacterial pathogenicity while also aiding in the immune response HEL-S-28 ASB1 EGFR AVP PMC11234204__F5 Regulatory factors involved in sensitivity and resistance to ferroptosis in HCC patients treated with sorafenib GPX4 FACL4 CISD2 ZNF263 SLC7A11 LCN2 C8orf76 SCD NF2 ATF4 SLC3A2 MCL1 DAZAP1 STAT3 FASN PMC7672575__F5 Signaling pathways of MD-2/TLR4 axis that lead to stimulating the immune responses TBK1 SOCS3 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR4 IL1B TIRAP TAB3 MAL PMC4701050__F3 Origin and in vitro generation of eCPCs MESP1 Meflin KDR NODAL PDGFA DKK1 SHF MEF2C GATA4 ISL1 PMC7672575__F7 Potential antiviral mechanisms of action for honey contain caffeic acid, CAPE, galangin, and chrysin against SARS-CoV-2 GAL ACE2 HEL-S-69p PMC5882022__F1 The regulatory roles of different sirtuins in the reprogramming of human skin fibroblasts to generate induced pluripotent stem cells SIRT2 SIRT7 SIRT4 SIRT5 LIF SIRT6 NMNAT3 SIRT1 STAT3 SIRT3 PMC7716408__F6 Proposed molecular mechanisms for PA regulating ferroptosis in IRI-AKI GPX4 SLC7A11 SLC3A2 PMC11234204__F1 Canonical mechanism of ferroptosis GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 ALOX15 GLS2 SLC38A1 HEL-75 SLC3A2 DHODH ACSL3 TF PMC11234204__F4 Metabolic dysregulation mediates ferroptosis in HCC GPX4 SLC27A4 SCD STAT2 DHCR7 SLC7A11 BCAT2 TMEM147 PNO1 SLC3A2 HCAR1 PMC3243079__F2 Non-genomic ERA pathway FOS SRC JUN PMC2896911__F8 Regulatory network that links the activities of an ensemble of transcriptional regulators, signaling components and survival factors in developing B cells into a common pathway RUNX2 CTCF RAG1 HOXA7 PTEN CEBPB SOX4 SIRT3 BASH E2F2 POU2F1 PAX5 NOTCH1 EZH2 ETS2 IRF4 GATA3 CD19 EGR1 RUNX3 IRF8 ERG HDAC7 VPREB3 BLK CD79B VPREB1 FOXO1 CD79A ID3 BCL6 LEF1 GIG8 CXCR4 BCL2 SYK STAT3 PMC7766288__F2 Mechanisms of several lncRNAs in CC PTEN EZH2 MTOR PCNA BLACAT1 PMC11234204__F3 NRF2 is involved in preventing lipid peroxidation and ferroptosis in HCC ADIPOR1 GPX4 KEAP1 SLC7A11 FTH1 QSCN6 NQO1 GSTZ1 IGF2BP3 HEL-75 SLC27A5 SLC3A2 SIRT1 CEP290 PBR CPLX2 FNDC5 PMC5994595__F3 Excitatory toxicity model of methamphetamine NUPR1 ATF4 PMC5506270__F1 T cell signaling, activation and antigen recognition APC PMC7897342__F2 Role of the ATF/CREB family in the pathway involved in hepatic lipid metabolism FGF21 APOA4 CPT1A ATF4 EIF2A TG CREBZF SPHK2 APOA2 NR1C1 SIRT1 PMC3711318__F10 Proposed model for activation of the ATR/Chk1 signaling pathway and G2/M phase cell cycle arrest induced by HNE CCNB1 CDC2 PMC8080578__F4 New paradigm for the regulation of STAT2 protein in melanoma formation STAT2 GSK3B GSK3A FBXW7 PMC3856238__F6 Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides NDUFB11 NDUFV2 TRO HEL-S-66p MDH2 NDUFA13 NDUFB10 NDUFB3 OGDHL PPA2 ADA ACLY SDHD SDHA SDHB PMC4207979__F1 One-carbon metabolism is required for the synthesis of purines, thymidylate (dTMP), and methionine HEL-S-182mP DHFR TYMS HEL-S-51e MTHFD2 PMC3515668__F1 Schematic representation of the potential disruption of the hepatic GHR-JAK2-STAT5b signal transduction pathway by TCDD SOCS3 AHR GHR PMC6082850__F8 Antidepressant and anxiolytic mechanism of acupuncture in a PTSD rat model SYN1 EIF4E MTOR PMC7860207__F2 Significantly enriched Cell Cycle pathway from genes with high DE prior probabilities E2F4 CCNA2 PLK1 SFN TTK HEL-S-1 SMAD2 GSK3B MYC CCNH SMAD4 RB1 CDKN2A TFDP1 DBF4 ORC3 ORC2 CDK7 SMC1A ATM CCNB1 MDM2 CCND1 CDC27 CDK4 CDC2 RBL1 CCNE2 ORC6 SKP1 GADD45A STAG1 CHEK1 HDAC1 CDC45 CDC20 MCM2 CDKN1A CDC6 SMC3 CDK2 ORC1L TGFB1 PCNA SKP2 PMC6828713__F1 Otub1-mediated regulation of the IL-15 signaling pathway IL15 JAK1 MTOR PMC8499812__F6 DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-seq data EIF4A1 GPX4 CREB1 PSMB3 MRPL57 IKZF3 SP100 HEL-S-108 E2F2 ARF4 DUT LPXN SNX3 HMGB2 SLA PTBP1 RPS27L ZNF683 ZNF207 ADAR CASP3 NFATC2 MAX ADA ZNFX1 VCP AKNA MEF2C TF PMC6521935__F7 Mechanism of salidroside-induced apoptosis, cell cycle arrest and suppressed invasion of osteosarcoma cells via inhibition of the JAK2/STAT3 signaling pathway CCND1 STAT3 BAX PMC8698620__F8 Murine Neonatal Oxidant Lung Injury: NRF2-Dependent Predisposition to Adulthood Respiratory Viral Infection and Protection by Maternal Antioxidant AKAP11 NBN PSMB3 WAS RB1 RGS14 CCL24 FOXL1 KLC2 JUNB ABL2 SUGP2 SST LTB GRIA3 LCN2 MVK RRAD FAM83D TNF GRHL3 INSIG1 EGR2 TIFA MPZL2 CS PPFIBP1 SFN RNMT LEO1 IL12A MAPRE3 CDCA2 PTCHD4 MX1 GCM1 ENDOD1 MORC3 MSC STK10 UTP3 ARHGAP22 MAL MAFG MKX ARID3A MAFF RRAS TCN2 TTC32 KLF17 GAREM2 FXYD4 NEK3 SCUBE1 CCDC61 BBC3 NCAPG CD40 KIF21A PMC7387650__F3 Regulation on the suppressive nature of MDSCs by subset composition and the tumor microenvironment MTOR ARG1 POLI FOXP3 PMC5402913__F1 Profile of romosozumab and its potential in the management of osteoporosis GSK3B TEF LRP5 LRP6 PMC3696710__F1 Constitutive components and the transduced mechanisms of Hh signaling pathway SUFU GLI3 GSK3B SMO GAS1 PMC8001022__F2 RAGE structure and signaling pathway HMGB1 TLR7 TLR9 MYD88 TIRAP PMC11021430__F5 Representative scheme illustrating regulatory mechanisms of PTEN in BMSCs MAF IGF1 ATM DLL4 APC GSK3B MDM2 DLK2 PTEN DLL3 MTOR ATR PMC11021430__F7 Representative scheme illustrating regulatory mechanisms of PTEN in HSCFs, SCs, ISCs and SSCs MAML1 KIT ATG12 ATG3 BMP2 EGFR PTEN ATG10 FOXO1 DKFZp686F0183 KL RET SRC PMC11021430__F6 Representative scheme illustrating regulatory mechanisms of PTEN in RPCs EGR1 SAG SMAD2 FGF2 PTEN MTOR IRS1 RHEB HES1 TSC2 HES5 TSC1 IGF1 SUFU PTCH1 KLF4 SHH SMO PMC3545532__F2 Model depicting the canonical Nrf2 stress response pathway in each of the different phases: basal, preinduction, induction, postinduction FYN GCLC GSK3B PTEN BACH1 PMC5977125__F1 Overview of the cap-dependent translation initiation ELF2 ELF5 ELF3 ELF1 SUI1 EIF4E MTOR EIF5 PMC9425624__F2 Mast Cells in the Pathogenesis of Pruritus in Mastocytosis MRGPRX2 NGF CALCRL RAMP1 ITCH PMC1995566__F7 Oxidative stress initiates a cascade of reactions leading to cell death via one or more sequences of molecular events CASP3 BAD CASP9 PMC6049067__F6 MiR‐26a‐5p as a novel HB repressor LIN28B RAN AURKA PMC4081859__F2A Complement regulation of T cell immunity APC PMC8050425__F5 Can1 and Mup1 endocytic pathways triggered by distinct signals MCC PMC7215397__F3A Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA) KDR GRB2 HEL114 PXN PMC9120625__F6 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression GSK3B RB1 BDNF PMC6206761__F2 Interconnected responsible pathways to cause amyloid and tau accumulation CD33 BIN1 EPHA1 PICALM CR1 CD2AP APOE CLU PMC6104488__F2 Schematic illustration of the PTEN regulated PI3K-AKT-mTOR signaling pathways in CNS axon regeneration GSK3B PTEN PMC8469189__F2 Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry MSC IL6 PMC11563972__F3 Curcumin in the treatment of Parkinson’s disease (PD) TLR4 KEAP1 PMC11588630__F1 AIM2 inflammasome activation signaling pathway TBK1 CGAS GBP1 STAT2 GBP2 GBP5 IRF3 TYK2 AIM2 GSDMD PMC3936406__F1 Molecular signaling pathways mediated by MET receptor tyrosine kinase in neurons HGF GRB2 CD44 SRC RHO RAC1 MTOR AXL CRKL CDC42 STAT3 PMC7809845__F4 Prolactin signaling pathway (KEGG ID: hsa04917) TH FOS GSK3B GCK PRL CCND2 SHC2 CISH PRLR RELA GRB2 SRC AKT3 PMC12178017__F6 EGb761 suppressed vascular dementia via modulating Wnt/Beta-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells TFEB SQSTM1 IRGM DKK1 PMC2045624__F1 OX40 signaling directly triggers the antitumor effects of NKT cells CD1D CD40 CD80 PMC5221490__F6 Intrinsic and extrinsic factors used during vertebrate lens development RBPJ ACVR1 SOX2 APC LRP5 FOXE3 SMAD4 LRP6 SOX1 PROX1 MTOR HES1 PITX3 GRB2 SMAD1 DKFZp781O1323 PMC4613668__F2 MAPK/JNK signalling: a potential autophagy regulation pathway ATG12 AMBRA1 ULK2 RAC1 BNIP3 DKFZp686F0183 PMC4148035__F6 A negative feedback role of miR-326 in the Shh signaling pathway SHH SMO PMC7584566__F5 Schemes depicting hormonal axes involving insulin-producing cells (IPCs) in adult flies APC PDF PMC8222562__F1 SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining RAD50 RAD51 MRE11A PMC11588630__F4 Regulatory mechanism of AIM2 in tumor cell proliferation and migration MTOR AIM2 STAT3 PMC11588630__F3 Regulatory mechanism of AIM2 in inflammatory response CXCR3 NLRC4 CXCL10 MYC MTOR AIM2 IRF-1 PMC11588630__F2 Other signaling pathways of AIM2 NLRP3 CGAS RIPK3 IRF3 IL1R1 IL23R AIM2 IRF4 FADD MLKL GSDMD PMC6150497__F3 Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator SOCS3 GSK3A PTEN GYS1 TBC1D4 IRS1 RCOR1 RAB10 RICTOR TSC1 TNFRSF1A KLF4 ATXN2 PMC7600282__F4 Target points of the dietary compounds on mitochondrial dynamics and mitogenesis, with a particular focus on mitophagy NRF1 ATG3 FOXO3A FUNDC1 MTOR SMURF1 FOXO1 SIRT3 PINK1 TFEB PARL TFAM FIS1 PMC6876298__F2 Dysregulation of the complement cascade in C3 glomerulopathy HEL-S-62p CD59 CS CD46 C4B_2 FH CR2 C1S C4A CR1 PMC2993855__F2 Pathways correcting DNA polymerase errors MLH3 MSH6 MSH3 MSH2 PMS2 PMC4511812__F1 Hematologic malignancies: at the forefront of immunotherapeutic innovation HMGB1 IL7 APC IL7R PMC6057898__F3 Interplay between melatonin and clock genes in joint during OA NFIL3 ACAN COL2A1 IL1B SIRT1 PER2 SOX9 PER1 PMC7280868__F1 Canonical autophagy pathway ATG16L1 ATG12 WIPI1 WIPI2 CSA2 ATG10 DKFZp686F0183 PMC11855613__F1 Diagrams summing up the pathogenetic pathways relevant to BBB disruption in TBE and discussed in the paper MMP3 MMP7 MMP9 TNF PMC8276315__F8 Small-molecule modulators of INAVA cytosolic condensate and cell–cell junction assemblies INAVA TRAF6 MTOR NOD2 PMC3405863__F4 EGFR pathway in Drosophila EGFR GRB2 STAR PMC2721689__F1 Structural and functional modules in RNA interference DGCR8 RNASE3 DROSHA PMC3405863__F5 Segmentation clock oscillator HES5 FRS2 APC GRB2 LFNG NRARP LRP6 HES7 DKK1 HES1 PMC3513309__F3 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine ITK LCK GRB2 TEC PTEN RAC1 MTOR CD79B CDC42 CD19 PMC8799543__F2 Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury NLRP3 RPS13 ACKR3 CD44 HEL-S-44 IL8RB CD74 IL1B PMC3970144__F6 HCV assembly involves a concerted action of all viral proteins and hijacks the host lipoprotein synthesis pathway DGAT1 APOB APOE PMC7365859__F1 Legend: A schematic view of the involvement of zinc in various signaling pathways TANK MYC PMC6704288__F5 Proposed model of the combined effect of ROR1 inhibition and erlotinib treatment in non-small cell lung cancer cell lines via inhibition of the AKT/mTOR signaling pathway EGFR PTEN MTOR IRS1 ROR1 PMC6115979__F3 TRPM7 kinase in T cell signalling and transcriptional regulation RORC SMAD2 ITGAE TGFBR1 SMAD4 IL6R TRPM7 TF STAT3 PMC6932917__F10 RXFP3 in DNA damage response and repair RLN3 ATM BRCA2 MDC1 RXFP3 RAD51 PARP1 GIT2 H2AX PRKDC MRE11A BRCA1 PMC3513309__F4 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine BAD EPO CSK CTLA4 EIF4E MTOR RBX1 GATA4 BTK BCR GAB2 ZAP70 MDM2 GRB2 CD40 SYK CD80 FLT3 CDC42 PMC3103499__F3 Computational Identification of Transcriptional Regulators in Human Endotoxemia CSF3R CXCL2 TNF CASP10 HEL-S-32 MDH2 GLO1 CCL20 ACLY IRAK3 INHBB IL1B MZF1 TNFRSF10C PMC8604044__F2 Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder SQLE HMGCR PMC5828651__F5 RNA-editing regulated genes in LUAD are enriched in apoptosis and innate immune-related genes ELF2 DFFA TNF MAVS PMC7870930__F3 Progress in understanding the role of lncRNA in programmed cell death RIPK1 RIPK3 TNF MLKL PMC6307844__F1 Pathways participate in tumourigenesis of CCA APC GSK3B PMC3809585__F3 TAM-regulated cycle of inflammation in dendritic cells TLR4 TRAF3 TRAF6 AXL TLR3 PMC7904626__F1 Biosynthetic pathway of oxetanocin-A (1) FES CBL PMC3809585__F2 TAM receptor signaling pathways STAT1 GRB2 CRK SOCS1 PMC4977063__F7 Model deciphering the signalling pathway hijacked by EspT leading to induction of inflammatory responses in macrophages IL16 RAC1 IL1B CDC42 PMC9522918__F4 Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma TH PMC11351628__F1 PPAR targets and contributing factors in MASLD/MASH DGAT2 APOC2 APOC3 HEL-S-104 TG NR1C1 MTTP MOGAT1 TFEB LPL SLC27A1 EHHADH APOE CD36 PMC8261853__F2 Host Modulation and Treatment of Periodontal Disease RORC GSK3B JAK1 TNF IL6R PMC4174666__F4 Generation of a biological network of genes related to the upstream regulator IRF2 NAMPT IFIT2 HAMP VCAM1 PF4 HELZ2 NMI CCNC SERPINE2 IRF2 IRF-1 STAT3 PMC6794554__F1 Wnt signaling with two intersecting networks: Canonical Wnt (or Beta-catenin-dependent) and non-canonical Wnt (or Beta-catenin-independent) pathways CDK14 ATF2 APC GSK3B LRP5 LRP6 ARHA ROR2 RAC1 ROR1 CDC42 PMC7515827__F2 Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications HEL-S-26 PIG59 DPYD TWIST1 FH ASNS EGFR NNMT FAAH ACLY CDH2 HMGCR PMC6927537__F2 Kinase alterations and signaling pathways dysregulated in Ph-like ALL ABL2 EPO PDGFRA ETV6 INS NRAS NTRK3 MTOR POR CRKL CSF1R FGFR1 CRLF2 LYN TYK2 JAK3 JAK1 FLT3 IL2RB PMC7766727__F3 PI3K/AKT signaling pathway with plant-based inhibitors (created by BioRender.com) TSC2 BAD TSC1 APC LRP5 LRP6 PTEN FADD RHEB PMC8507398__F10 Molecular biology of autoinflammatory diseases TRADD IRAK1 TRAF6 IRAK4 MYD88 RIPK2 MAP3K7IP1 NOD2 RIPK1 TRAF5 CYLD SHARPIN TRAF2 OTULIN TIRAP PMC7084529__F11 Altered sphingolipid and gene transcript levels in ASAH1KD SH-SY5Y cells ASAH2 SGPP1 SGMS1 SMPD2 ACER3 LASS1 SMPD1 CERS5 DEGS1 CERK KDSR CERS2 PMC12144744__F4 Antitumour mechanisms of statins TBK1 GC IL33 IRF3 RHO IPP HMGCR PMC12144744__F1 Mechanism linking dyslipidaemia and gastric cancer VEGFC CCL24 VCAM1 GC CCL17 SRC BCL2 CCL22 STAT3 CD36 PMC4842340__F2 Involvement of the prohibitin (PHB/PHB1) in granulosa cell (GCs) survival and differentiation functions BCL2 STAR OPA1 BAX PMC8887676__F7 Therapeutic potential of the PI3K/AKT/mTOR axis for the management of AD and cancer CDK2 CDK5 CCND1 MTOR PMC3675076__F5 Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy SMO HDAC1 PMC5003605__F1 Metabolic pathways and genes involved in the utilization of nonfermentable carbons GID8 PCK1 F2 FBP1 MDH2 PMC4730127__F3 Targeting of the genes and pathways for stem cell maintenance by miR-200 family miRNAs MAML3 ZEB2 MAML2 BMI1 PMC3590494__F4 Significant molecular network of combination therapy related metabolites SKI PTER PMC7303382__F8 Neuroactive ligand–receptor interaction pathway MLNR GHSR PTGFR APELA GIPR LPA SCTR TACR2 PRL TRPV1 LEP LEPR FSHR PMC6423002__F1 AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency ULK1 SOX21 SOX2 MTOR PMC11894577__F8 KEGG website to retrieve a map of the key pathways of CE action in ovarian cancer MYB BAD PTEN RAC1 EIF4E MTOR RHEB RXRA TSC2 TLR4 BCR MDM2 GRB2 SYK RBL2 CD19 PMC7063117__F3 Regulatory role of miRNAs in OP-associated pathways SCD RUNX2 NFATC1 ERG APC EGFR GSK3B LRP5 TRAF6 LRP6 CBL PMC8035314__F3 Signaling via the IR and IGF-1R TSC2 BAD TSC1 GRB2 PTEN RHEB PMC8151052__F1 Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer FRS2 GRB2 CBL PMC8035314__F2 Functional outcomes of the IR/IGF-1R/IRS pathway in normal and breast cancer settings IGF1R IGF1 SHBG IGF2 PMC3590501__F6 Proposed mechanism for the protective effects of carvacrol against hepatic steatosis in mice CD14 DHCR7 FDPS IRF3 MYD88 MTOR HMGCR CD36 PMC9618889__F6 Major pathways involved in macrophage polarization in cancer ANXA1 GRB2 SRC PTEN STAT3 PMC7407119__F2 The antioxidative landscape in the cell, and the corresponding modulators of key players KEAP1 SFN HEL-S-64p HEL-75 TXN PMC6509080__F2 Mechanistic pathways underlying reverse cholesterol transport from macrophages to liver PLTP ABCG1 LDLR ABCA1 TG APOE PMC7407119__F1 The major sources of reactive oxygen species (ROS) in the cell and the corresponding inhibitors of those sites NOX4 ERO1A DHODH PMC5854933__F1 WNT pathway TNIK CDX2 APC GSK3B LRP5 FZD7 LRP6 HUWE1 TMEM88 DKK1 DACT1 WWOX PMC7299226__F6 Metabolic pathway showing lysoPL (lysophosphospholipids)/lysoPA (lysophosphatidic acid) regulatory genes that are significantly altered by ANRIL knockdown in HEK cells.Genes that metabolize these lipids are shown PLPP2 PLPP1 LPCAT3 LPCAT1 LPCAT2 DGKA ACSL6 PLA2G7 PC PLPPR2 ENPP2 PLBD1 PLA2G4C PNPLA2 PMC5877728__F1 Overview of the stress-activated protein kinase (SAPK) pathway TNIK ZAP70 MAP3K7IP1 PMC4005386__F2 Signaling networks for brain, lung, and bone metastases of breast cancer IKBKG DKFZp781B1423 FLNA HEL-S-1 PARD6B NCK1 CCT8 FYN KDR MDM2 HDAC2 RPS27 RPS14 MAP3K1 FBL WIPF1 RPL4 RAC1 CDC25B HDAC1 PHGDH IKBKB SEC16A NFKBIB RET KHDRBS1 EP300 SUV39H1 NFKB1 RELA AKAP8L GRB2 HEL113 REL HEL-S-93 ACTG1 CDC42 RPS23 PMC7738904__F1 Essentials of TGFB signaling pathway SMAD2 SMAD4 PMC2854249__F2 Mammalian autophagy: core molecular machinery and signaling regulation TSC2 BAD TSC1 GRB2 PTEN IRS1 RHEB PMC4960093__F3 General summary of altered mitochondrial functions in cancer cell life and death MYC BCL2 HIF1A BAX PMC3495133__F1 Schematic of the desaturation and elongation biosynthetic pathway of essential dietary fatty acids to longer chain fats FADS2 FADS1 GLA PMC2854249__F1 Mammalian autophagy: core molecular machinery and signaling regulation ULK1 TP53INP2 AMBRA1 UVRAG VMP1 PMC4699388__F7 Overexpression of E2F-2 abolishes the PPP-mediated inhibition of terminal differentiation in Gata1S310A erythroid cells ex vivo IGF1R EPO IGF1 ING1 ALAS2 ERAF PMC7946848__F3 Possible roles of circRNAs in SLE RNASEL EIF2A PMC5869074__F1 Cross-talk between protein synthesis, energy metabolism and autophagy in cancer EEF2K ULK1 ATG12 EEF2 PTEN ATG101 EIF4E IRS1 RHEB TSC2 TSC1 ATF4 EIF2A PMC11774878__F4 Functions of non-coding RNAs that target ferroptosis and EMT in TNBC metastasis GPX4 USF1 RHOT1 SLC7A11 NR3C2 STAT3 PMC8983758__F2 Feedlot diets containing different starch levels and additives change the cecal proteome involved in cattle’s energy metabolism and inflammatory response PCK1 GCK PFKM HEL-S-32 MDH2 GOT2 PC HEL-S-278 SLC2A2 SLC2A3 MPC1 PDHA1 MPC2 PDHX PFKP DLAT PGAM1 HEL-S-133P HK2 PGAM2 HEL-S-281 PDHA2 ALDOB ENO3 HK3 FBP2 FBP1 ENO1 DLD PFKL HEL-S-87p HEL-S-162eP HEL-S-68p HEL-S-49 SLC2A4 ENO2 PMC11774878__F3 Crosstalk between ferroptosis and EMT in TNBC metastasis GPX4 FACL4 TWIST1 NF2 LATS1 TFRC CDH2 LATS2 MTHFD2 PMC1857267__F2 Altered macrophage differentiation and immune dysfunction in tumor development JAK3 NOS2 ARG1 CEBPB PMC8036852__F3 Brucella can inhibit the secretion of IL-2 by antigen presenting cells, and then prevent natural killer cells (NK) from secreting inflammatory factors such as IFNG and TNFA APC CD80 PMC11774878__F2 EMT in TNBC metastasis KIF23 FOXM1 RBMS3 GSK3B PRRX1 YTHDC1 PMC8482137__F4 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups B3GAT3 UGT1A4 UGT1A3 UGT1A9 SULT1A2 UGT2A2 UGT2B10 DIO1 UGT1A5 UGT2A1 B4GAT1 PMC8482137__F3 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups PIK3R1 MAP2K1 MAP2 MYC INS CXCL8 CCND1 PTEN JUN PMC3962195__F1 Biological processes and genes implicated in the Parkinson's disease CASP3 SNCA KY LRRK2 CASP9 HTRA2 PMC2907698__F4 An example of combined analysis of three identified regulatory modules DUSP4 BAD BRAF ATF2 EGFR PRKX PTEN RHO CALM1 NFATC2 MAX GRB2 BCL2 JUND C13orf34 JUN PCNA BAX PMC7279161__F4 Comparison of Nrf1 and sterol regulatory element-binding protein (SREBP) activation pathway MAF DDI2 NRF1 NGLY1 PMC3972652__F1 Biosynthesis pathway for gangliosides GAL GATC ST8SIA1 B3GALT4 PMC5424241__F5 Leukocyte extravasation signaling pathway CD99 VASP PRKCE ARHH MMP11 TEC NCF4 ITGA4 ITK MMP7 BTK MMP2 UNK HEL114 MVP CLDN11 MGAM TXK MMP9 CD44 MMP16 CRK FER PRKCB CXCR4 NCF1 PXN JAM2 NCF2 PMC3731064__F2 Chromatin and the genome integrity network BLM RBBP8 DNA2 PMC8753987__F6 Top-Down Enrichment Strategy to Co-cultivate Lactic Acid and Lignocellulolytic Bacteria From the Megathyrsus maximus Phyllosphere PDC XK RPE PMC12179905__F1 Pathways of apoptosis ATF4 TNF BAX PMC8148105__F1 IDARE2—Simultaneous Visualisation of Multiomics Data in Cytoscape HEL-S-62p C6 CEBPA PAH PPARG GPAM AGPAT5 PMC12179905__F2 Common signaling pathways affecting apoptosis: Phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway and wnt/Beta-catenin signaling pathway APC GSK3B MTOR BAX PMC3433899__F3 Single gene and protein network generated by Approach 3 (Network 1) that demonstrated significance as a clinical relapse predictor following a stringent permutation based test HEL-S-102 DCN COL14A1 C4B_2 CRABP2 FTH1 PARP1 CNN2 ACLY MVP MYLK PMC3977653__F1 At Loose Ends: Resecting a Double-Strand Break RAD51 DNA2 PMC3406577__F6 Restoration of cell death by ABT-737 in cancer cells that overexpress Bcl-2 and caspase activity is blocked HTRA2 PMC6007953__F1 XIAP regulates apoptotic and inflammatory signaling pathways TRADD TNF TRAF2 NOD2 FADD PMC8567306__F5 Clinical translation of immunomodulatory therapeutics IL2 JAK3 JAK1 PMC7567935__F15 Pre-treatment of rats with melatonin (10 mg/kg bw) prior to ISO treatment (25 mg/kg bw) prevented occurrence of myocardial infarction and averted mitochondrial dysfunction caused by ISO mediated oxidative stress PGC LPO SIRT1 SIRT3 PMC5425951__F2 Ingenuity Pathway Analysis network showing the relationships between several assayed genes (emphasized with black arrows) HLA-A LILRB4 DMBT1 CLEC10A TYK2 CTSZ PMC10933033__F3 Pro-inflammatory cytokine expression by interleukin receptors via STAT and IRF transcription factors STAT1 CD40 IRF3 IRF4 PMC10933033__F2 TOLLIP-mediated regulation of IL-1R signaling IRAK1 TRAF6 PMC5149546__F7 Putative triterpenoid saponins biosynthesis pathway in A IDI1 IPP PMC6291243__F2 Biosynthesis of the ADR-GlyU disaccharide core 17a LIPM LIPK LIPN PMC4864225__F3 Hypothesis on skeletal muscle adiponectin resistance in chronic heart failure ADIPOR1 SIRT1 FOXO1 PMC10933033__F4 Adaptor protein SLAP-2 regulates CSF1R-mediated differentiation and survival of macrophages CSF1R GAB2 GRB2 PMC2997336__F1 Model illustrating the signaling pathways activated by optimal DA and hyperdopamine GSK3B CDK5 PMC8476809__F2 Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers ULK1 ATG12 SMAD2 PAX7 TNF MTOR DKFZp686F0183 TSC2 PINK1 MFN2 TSC1 IGF1 ATF4 EIF2A FIS1 OPA1 BAX PMC10933033__F1 Adaptor proteins mediating the signaling of TLR receptors DOK3 TLR4 CLIP4 SOST TRAF3 GRB2 TRAF6 IRF3 MYD88 TIRAP PMC8135095__F1 Microglia: A Double-Edged Sword in Intracerebral Hemorrhage From Basic Mechanisms to Clinical Research STAT1 TLR4 IFNG PMC8044534__F2 Diverse range of signals in the TME which could induce HMOX1 expression KEAP1 BACH1 STAT3 PMC8392882__F5 Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications EGF GRB2 CCND1 PMC3035360__F1 Synthetic view of the p53 pathway PML PLK2 PIN1 ID4 MYC MDM2 BAX PMC4329310__F4 Detailed view of protein secretion pathway KEAP1 ATF4 EIF2A XBP1 UGGT1 PMC9142883__F7 Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer’s Disease in APP/PS1 Transgenic Mice CTRB1 LAT2 CTRL NACA PMC3933272__F4 WNT signaling pathway NLK ARHH HP SI HEL-S-11 APC PMC6015534__F1 Schematic describes the major developmental steps that underlie the differentiation of preskeletal mesenchymal cells toward endochondral (right) and intramembranous (left) ossification RUNX3 RUNX2 ATF4 SOX5 SOX6 MEF2C SOX9 MEF2D PMC11658145__F7 Schematic summary of the effects of PEVs on the MV3 and A2058 spheroids CD9 CD63 CRP CD81 PMC8054189__F1 Aminoglycerophospholipid biosynthetic pathways in yeast, Saccharomyces cerevisiae CDS1 PC PSD2 PMC7664432__F1 Complex regulation of E-cadherin expression SMO STAT3 PMC4380406__F1 Impact of Host Diet on Wolbachia Titer in Drosophila TSC2 TSC1 MYC RHEB PMC8220701__F1 Genome-wide expression and network analyses of mutants in key brassinosteroid signaling genes SNRK MAX BAK1 BIN2 PMC9261067__F7 Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation MMP2 FOXM1 MMP9 PMC7468828__F7 Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in the medullary thick ascending limb TLR4 IRAK1 MYD88 TNF PMC4800028__F1 CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance ADIPOR1 ADIPOR2 TLR4 CD36 PMC11741906__F5 Effect of differentially expressed miRNAs related to cisplatin resistance on MAPK signaling pathway NLK DAO MAX FLNA AKT3 PMC7779440__F3 TNF Signaling Pathway (Retrieved from KEGG) as One of the Pathways of Brazilin Targets in Metastatic Breast Cancer CASP3 MMP14 LIF TNF MME FADD SELE ITCH PMC3097535__F5 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities STAT1 NR1C2 CHRNA3 CP PMC8305863__F2 Of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy TBK1 CGAS IL18 TLR4 TLR9 BCR IRF7 APC TRAF6 IRF3 MYD88 NOD2 PMC3097535__F4 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities F2RL1 CTNND2 RPL23A CP PMC11171836__F11 Mechanism by which Pin1 regulates NAFLD PIN1 CPT1A FASN PMC6700826__F7 Putative regulatory pattern of PoSet1 and PoSet2 on cellulolytic enzyme gene expression ME1 ME2 ME3 TF PMC8870972__F3A Eutopic Endometrium Proteome in Endometriosis Reveals Candidate Markers and Molecular Mechanisms of Physiopathology TSC2 BAD CD37 BCR MDM2 SYK PTEN MCL1 RBL2 RHEB CD19 PMC3165467__F6 Results of Ingenuity pathway analysis ELANE APOH PMC3878201__F4 miR-34a mediates paclitaxel resistance via both direct and indirect mechanisms ZEB2 BCL2 SIRT1 CDK6 PMC12075250__F2 AECAs pro-apoptotic and pro-inflammatory effects in ECs VCAM1 FADD BAX PMC1770611__F2 Axin in Wnt signalling APC PMC6328866__F3 Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma E2F8 KLHL23 LBX1 KIF23 RAB37 C11orf21 SLC25A33 GNG7 TPO TSTD1 DRD4 DTL HSD17B10 HEL-S-66p DEPDC1 VBP1 ZNF350 STIL ADSL SKA1 MFAP1 MCM10 KIF15 DLGAP5 PGAM1 HEL-S-133P GPNMB NAMPT HIVEP2 UCN2 NPPC FAM83D CDCA8 CACNA1I ZFP36L2 CDC20 AIMP2 GAPT SCGB3A1 ACP2 AK5 FOXN2 DEPDC1B PCNA TRIP13 CRHR2 CCR6 TTK GLIPR1 GINS1 DBF4 BYSL MRPL15 NUF2 GPN3 FCER2 FRK RRM2 ZBTB16 RCAN3 RAD51AP1 MASTL PHOX2A MYBL2 SCT RPL37A MAD2L1 DEK ALDH18A1 SKA3 HEL-S-162eP TSPYL5 HCN4 BUB1B SNRPB HEL164 KLHL34 SPNS3 ZWINT TRAF3IP3 TULP4 HCN2 ZMAT1 GPR150 ZSCAN10 CASKIN1 SLBP ZNF823 PMC10750287__F4 Cross-Communication of Cuproptosis and Regulated Cell Death in Human Pathophysiology CASP3 NLRP3 NLRC4 CASP8 GSDMD PMC8634458__F1 Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer TBK1 CGAS IRF3 PMC10750287__F6 Molecular mechanisms of autophagy triggered by excess Cu ULK1 ATP7B SCO2 COX17 KEAP1 SCO1 ATP7A F2 ATOX1 HEL-S-44 MTOR CCS PMC11741906__F4 Effect of differentially expressed miRNAs related to cisplatin resistance on PI3K-Akt signaling pathway BAD BCR PTEN RBL2 CD19 PMC8071856__F1 Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide NAMPT NRF1 TFAM SIRT1 PMC8898094__F4 Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling POLR3A TIMM44 CHD4 AHNAK HSPD1 S100P VAPA PC PSMC6 EIF3B MSH6 PDHA1 RAD50 RNPS1 PSMC4 SUCLG2 RBM4 OPA1 HEL70 PLP2 PA2G4 EXOSC3 NUP214 GNA13 CAND1 ATP2B1 RPN1 HEL-S-68p HLA-A RAB21 PLAA RBBP7 SGPL1 EXOC4 ACTG1 NSUN2 CDC73 ZFR RPP25 VAT1 DNAJC7 SRRT PPP2R1A DHX15 EIF2S2 HEL-S-2a TNRC6B PHB2 SEC61A1 SRP14 HEL-S-30 DDX3X DECR1 FUS PRPF6 PS1TP5BP1 HEL-S-162eP SLC7A5 CREBBP EP300 CPT1A SEC22B ADRM1 AKAP8L BAG2 TRIM28 OTULIN RPL27A NUMA1 E2F8 AP2A1 CLCC1 EIF3A SURF6 CCDC47 MRPS2 ERGIC3 PABPN1 LUC7L2 FAM120A PNN CCAR2 EIF3G SND1 PICALM PDHX PPT1 LMAN1 ARCN1 ATP2B4 HEL-S-28 GAPVD1 MCM7 MCM3 AHNAK2 MCM6 TCERG1 CDC5L FDFT1 IPO9 FOXN2 FAM98B VCP RPS3 EGFR EEF1E1 SNRPA COG1 MTA2 S100A6 HSDL2 TGOLN2 NOMO1 SEC31A SEC61B PCBP1 MTDH FMNL2 KRT1 SEL1L FTH1 STOM CD44 TNPO1 PCCA DBT MAGED2 ITGB1 PES1 CANX EIF3F DNAJA2 HLTF ABCC1 AAG1 TPD52 BCAP31 TARDBP PMC6873421__F2 MET amplification causes EGFR-TKI resistance by activating EGFR-independent phosphorylation of ErbB3 and consequent downstream activation of the PI3K/AKT pathway, providing a resistance mechanism that can bypass the effects of an EGFR-TKI ERBB3 PDK2 EGFR PMC4099115__F4 IPA metabolic interaction network of plasma metabolites having a significant correlation with polyp counts in association with aGenotypebyDietinteraction effect FER AIP TES APP PMC4099115__F3 Metscape gene-compounds metabolic network views of top IPA canonical pathway and biological function/disease PARP14 PARP10 NNMT POLR2F ART5 ART3 ART4 PARP4 PARP16 POLR2B BST1 POLR2K POLR3B POLR2G TNKS PARP1 TNKS2 POLR2D PARP3 POLR3K PARP12 PARP11 POLR3F PARP2 TIPARP PMC2777340__F4 Drosophila insulin signaling pathway TSC2 RICTOR TSC1 GRB2 SHE PTEN RHEB PMC1622797__F5 Proposed molecular model of dietary omega-3 fatty acid interference with IL-1 signaling pathways leading to COX-2 induction in EC GP9 COX2 PMC9367715__F2 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells DPP3 PALB2 KEAP1 RBX1 PMC9367715__F1 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells KEAP1 RBX1 PMC5712004__F3 Model depicting targets of CHOP-dependent apoptosis EIF2A FADD BAX PMC8966655__F6 Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway GPX4 SLC7A11 PMC3961481__F1 Novel pathway links telomeres to NK-cell activity ATM HS3ST4 TPP1 ATR PMC9108237__F11 MicroRNA-382 Promotes M2-Like Macrophage via the SIRPA/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis SIRPA ARG1 STAT3 PMC6315745__F1 Chemoresistance LATS1 CDH2 LATS2 STAT3 PMC9652818__F1 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting YTHDF2 PDE1C IGF2BP1 TROAP ALKBH5 BMF TRIM29 DKFZp686F0183 EIF3C YTHDF1 METTL14 METTL3 UBA6 HOXA10 AXL FZD10 PMC7924916__F1 Severe acute respiratory syndrome coronaviruses’ lifecycle and possible mechanisms of interference with p53 and its regulatory pathways NPS PPIB MPL PHB2 HEL-S-69p PMC7795259__F1 Fibrosis related intracellular Ca2+signaling pathways PC HEL-S-11 MTOR PMC9652818__F3 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting YTHDF2 IGF1R IGF2BP1 PHLPP2 SOX2 PRR5 ALKBH5 WTAP MTOR PADI2 IRS1 SOX4 YTHDF1 METTL14 METTL3 PEG10 HOXB13 PMC8599155__F3 Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19 ACE2 TMPRSS2 TRPV1 PMC7403443__F1 Crosstalk between intestine and liver in the pathophysiology of NAFLD S1PR2 TLR4 FGF19 GIP NR1C1 PMC1839882__F9 Schematic illustration of the principal signaling pathways that are affected by sodium arsenite (As) treatment BRAF ATF2 EGFR STAT3 PMC5368685__F2 Pro-inflammatory response through TLR: various antigenic molecules are recognized differentially by TLRs, which produce pro-inflammatory responses TLR7 TLR4 TLR9 MYD88 TLR1 PMC12134845__F2 Amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review) IL10 HDAC3 AHR CXCL12 MTOR STAT3 GLS PMC12134845__F1 EAAs are crucial for osteoblast function; their deficiency activates MAPK signaling, causing cell cycle arrest, ROS accumulation, DNA damage and apoptosis NFATC1 MYC SLC7A7 PPY PMC6667378__F1 Graph representation of the Signaling by NOTCH2 pathway as extracted from the Reactome database NOTCH2 MAML1 RBPJ MIB1 CNTN1 MAML3 PSEN2 JAG2 UBB MAMLD1 UBC EP300 RPS27A DLL4 MAML2 ADAM10 PSENEN MDK NEURL1B MIB2 APH1B PMC5558095__F7 Noncanonical GLI1 signaling sustaining LAC growth and CSC maintenance VEGFA SHH SMO ABCG2 NRP2 PMC4742232__F6 Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERAlpha-ΔNp63-Integrin B4 Signaling Pathway ITGB4 SHH BMP4 PMC3966702__F7 ABCA1 expression and function can be induced by GPR119 to protect from atherosclerosis ABCA1 TNF IL1B GPR119 PMC7077540__F9 CXCL12 and receptor CXCR4/CXCR7 in placenta accrete spectrum disorders (PAS) CXCR4 RHO RAC1 CXCL12 CDC42 PMC8348042__F2 Transient Receptor Potential Channels in the Epithelial-to-Mesenchymal Transition EGF TRPV4 HGF SNAI2 TRPM7 SOX4 TRPM8 TRPC1 TRPV2 TRPC5 TRPC6 TRPC3 TRPM2 PMC6126184__F6 Pathway diagram presenting chaetominine mode of action associated with cell cycle regulation in SW1116 and K562 cells ATM CDK2 CDK4 ATR PMC9695749__F7 Mulberry Leaf (Morus alba L.) Extracts and Its Chlorogenic Acid Isomer Component Improve Glucolipotoxicity-Induced Hepatic Lipid Accumulation via Downregulating miR-34a and Decreased Inflammation NR1C1 SIRT1 FASN PMC4522377__F1 Multifaceted Control of DNA Repair Pathways by the Hypoxic Tumor Microenvironment FANCD2 RAD17 ATM MDC1 TLK1 ATR H2AX BRCA1 PMC3607745__F2 Cytokine and downstream signalling pathways in liver ischaemia reperfusion injury TLR4 CXCL10 STAT4 IL8RB PMC4145026__F1 Non-coding RNA regulation of synaptic plasticity and memory: implications for aging YY1 BDNF SIRT1 PMC7866901__F1 Expression characteristics and prognostic roles of autophagy-related genes in gastric cancer ULK1 ATG2B ATG3 MAP1LC3A ULK2 ZFYVE1 DKFZp686F0183 VMP1 ATG9B MAP1LC3B2 GABARAPL1 ATG9A ATG14 GABARAP ATG16L1 ATG12 ULK4 AMBRA1 NRBF2 ATG101 ATG10 DKFZp762B153 PIK3R4 MAP1LC3C GABARAPL2 ATG16L2 WIPI1 WIPI2 ATG2A RB1CC1 PMC8854490__F1 Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions TBK1 CGAS IRF3 PMC9222487__F8 Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases GHB2 TLR4 MAX HEL-S-133P STAT3 PMC7697665__F4 Role of RNF11 in the NFKB signaling pathway TBK1 RNF11 TRADD IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TRIM25 TRAF2 FADD TAB3 PMC7658606__F6 Diagram showing the mechanism of Tanshinone IIA on EMT and metastasis in colorectal cancer APC GSK3B CDH2 PMC7441421__F2 Signaling pathways mediated by CTHRC1 involved in the progression and metastasis of tumor SMAD2 APC GRB2 SMAD4 ARHA MTOR TGFA PMC5881740__F1 JAK-STAT signalling pathway IL2 TYK2 JAK3 IL6 JAK1 IFNG PMC5031078__F1 RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas NF1 PTEN IRS1 PMC5501956__F3 KEGG MAPK signaling pathway (KEGG ID: hs04010) CD14 NGF FLNA TRAF6 TNF NLK NF1 MAX FRK JUND ECSIT TRAF2 MEF2C PMC4745004__F8 Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile BAMBI FST PI3 E2F4 NODAL ROCK1 SMAD4 SKP1 ARHA THBS1 RBX1 IFNG PMC7864517__F2 In the absence of Hedgehog (HH) ligand (SHH, IHH, and DHH), the Patched 1 (PTCH) transmembrane receptor at the base of the primary cilium maintains inhibition of Smoothened (SMO) G protein coupled receptor (GPCR) signaling VEGFC TWIST2 KIF7 SOX2 SUFU GLI3 SHH BCL2 SMO PMC8901637__F6 Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased B2 adrenergic agonist BIRC2 MMP7 GPR55 GSK3B PFKFB4 LATS1 RHO MCL1 LATS2 HEL-S-133P PMC4568905__F5 2-Hydroxy Acids in Plant Metabolism HEL-S-162eP PMC8386020__F4 Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers EGFR INF2 RHEB PMC6031751__F8 CS negatively regulates IL-1B secretion in murine macrophages NLRP3 TLR4 IL1B PMC7738619__F1 Summary of the epigenetic regulation of the GSC phenotype KDM1A PRC1 ME2 NEK2 REST TUG1 TRIM24 ME3 KMT2E STAT3 PMC9104610__F6 Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling ANGPT2 ANGPT1 VEGFC VEGFA CALCRL TGFB1 PMC4932205__F4 Genes which are involved in the telomere maintenance and telomerase activity pathway XRCC5 TERF2 ATM TEP1 RAD50 NBN DKC1 TERF1 TERT PMC5477652__F1 Targeting the cyclin D–cyclin-dependent kinase (CDK)4/6–retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions GRB2 SHE CDK4 SP1 MTOR CDK6 PMC3808847__F1 Kisspeptin and Neurokinin B Pathway Deficiencies and Resulting Phenotypes in Mice and Men IHH KISS1 PMC3822533__F3 Unfolded protein response in mammalian cells ATF4 TRAF2 PMC7146376__F2 Location of CYP27B1 activity in the metabolic pathway of vitamin D (based on Jenkinson 2019 and Feldman et al CYP27A1 NR1i1 CYP2R1 DHCR7 CYP3A4 CYP24A1 CYP27B1 PMC4020326__F2 Glucogen‐like peptide‐1 and cancer IGF1R IGF1 IGF2 PMC7893032__F1 Cell death in head and neck cancer pathogenesis and treatment TRADD RIPK3 TNF MLKL PMC9170601__F3 Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy ATF7 ATF2 ATF1 ATF3 ATF5 PMC8199938__F5 Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders GPR55 FAAH TRPV1 PMC7893032__F2 Cell death in head and neck cancer pathogenesis and treatment NLRP3 HMGB1 RAC1 IL1B GSDMD DFNA5 PMC7193099__F2 Hippo pathway in heart development and homeostasis LATS1 LATS2 TAOK1 PMC7327153__F2 TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics IRAK1 TRAF6 IRAK4 MYD88 TLR1 TLR10 IL1B TIRAP PMC6389705__F1 Intrinsic and extrinsic pathways of neutrophil apoptosis TRADD TNF FADD PMC4268391__F1 RTK-PI3K-AKT signaling pathway TSC2 TSC1 IGF1R MYC PTEN MTOR RHEB PMC9325865__F1 Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) ELF2 ATF4 EIF2A XBP1 PMC8905337__F1 Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs GDF6 GDF5 gdf7 CRIPTO BMP2 SMAD2 MSTN GDF1 GDF10 GDF11 SMAD1 GDF3 TF DKFZp781O1323 PMC3018096__F1 Adapters in the organization of mast cell signaling FYN LAT2 GAB2 GRB2 PMC9406569__F4 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers TSC2 TSC1 CTSK TFEB TRAF6 MTOR RHEB PMC3149150__F2 Regulation of STEP phosphorylation ERBB4 FYN NRG1 PMC9406569__F6 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers CD14 CTSK IRF8 TGFBR1 SMAD4 MYD88 RAN AGAP2 TIRAP STAT3 PMC5056850__F2 Signaling via PINCH: functions, binding partners and implications in human diseases NCK2 HEL-S-28 RSU1 PMC9406569__F5 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers TSC2 TSC1 CTSK MTOR RHEB PMC3989668__F2 Ubiquitin-proteasome system maintains the balance between quiescence, self-renewal, and differentiation of HSCs.(A) The E3 ligases Itch, SCFFbxw7,CBL and SCFSkp2 maintain the quiescence of the HSC by targeting Notch, c-Myc, and STAT5, among others FANCD2 MDM2 VHL FBXW7 SKP2 ITCH USP1 CBL PMC4156155__F1 INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE TLR4 SRC PMC4030154__F2 Metals and cholesterol implicated in AB processing and neurotoxicity LDLR ABCA1 APOE PMC3630242__F1 Leptin and adiponectin activate signaling components that integrate PI3K/Akt, RAS/MAPK, and pAMPK/mTor pathways ADIPOR1 ADIPOR2 SOCS3 FOS PTEN IRS1 NR1C1 TSC2 CRP PPA2 CCND1 JUN APPL1 PMC3989668__F3 Ubiquitylation maintains the equilibrium between differentiation and transformation in adult stem cells ZNRF3 RNF43 APC SMURF2 FBXW7 ITCH PMC7665057__F6 Predicted pathway and network of all the 11 miRNAs IL10 PIK3R1 SLC25A20 GULP1 NUS1 VEGFA CXCL8 HIF1A SLC52A2 SNAP23 KLF3 FGF20 THRA FKBP1A BCL6 IL6ST NR1A2 PER2 PER3 PMC9039247__F2 Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases MPO PANX1 GLS PMC1716221__F1 Dominant role for glucose in B cell compensation of insulin resistance IGF1 GCK FOXO1 PDPK1 INSR PMC7763279__F2 Wingless and Int-1 (WNT) signaling pathways and their role during the osteochondrogenic transition of synthetic vascular smooth muscle cells (VSMC) WNT3A RUNX2 LRP5 LRP6 ROR2 SOX5 ACAN COL2A1 SOX6 ROR1 SOX9 PMC7055192__F3 Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies ABCG1 LDLR APOE PMC3218875__F2 Noncanonical NFKB signalling TRAF1 TRAF3 RELB CD40 TRAF2 LTBR PMC8534120__F2 Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment SPTLC1 SGPP1 SMPD2 SPHK2 ASAH2 SMPD4 PC SGMS1 ACER1 CERS3 SGPL1 ACER3 LASS1 SPTLC2 SMPD1 CERS5 SPHK1 SGMS2 DEGS2 KDSR CERS2 CERS6 SGPP2 PMC7763279__F3 Interplay of WNT and PPARG Signaling in Vascular Calcification HDAC3 APC LRP5 CCND1 LRP6 DKK1 SFRP5 PMC3902114__F1 Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression CCR2 CCL4 CCL2 PMC4516600__F4 A schematic pathway for one mechanisms of cisplatin-induced ototoxicity involves TRPV1 activation by cisplatin leads to NOX3-dependent generation of ROS to trigger STAT1 activation STAT1 NOX3 TRPV1 PMC9433531__F4 Mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations EGF EGFR MTOR PMC5812366__F1 Major mechanisms of therapeutic resistance to androgen axis-targeting therapies in prostate cancer EGF IGF1 SMAD2 TGFBR1 MDM2 SMAD4 BCL2 PTEN TRIM24 MTOR BAX PMC7333666__F1 Simple overview of the Hippo signaling pathway and YAP TEAD3 ERBB4 RUNX1 RUNX2 NF2 NRP1 TBX5 TEAD4 LATS1 LATS2 TEAD2 PMC7002859__F1 Steroidogenesis pathway involved in testosterone synthesis from cholesterol in testicular Leydig cells HSD3B1 HSD17B3 STAR PMC4128657__F4 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients RNASEL TLR7 IRF3 PMC4128657__F5 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients ISG15 RIPK1 IRF9 ATF2 IRF3 JUN GYPB PMC4491880__F1 Deoxycytidine biosynthetic pathway DCD OMP DUT PMC8387860__F2 Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls BAD APAF1 SRC BAX PMC9203694__F6 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies MORC2 ACLY PMC9203694__F5 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies PAK1 ATM PARP1 MORC2 CDC2 PMC5797330__F3 Endothelial Progenitor Cells for the Vascularization of Engineered Tissues PC EGFL7 RHO RAC1 CDC42 PMC8346997__F2 GPR39 in Neurovascular Homeostasis and Disease RHO BDNF GPR39 PMC12240974__F1 BAF60c in skeletal muscle glucose metabolism and regeneration DKK3 DEPTOR SIX4 PMC4824131__F1 NRAS mutant skin cell lines mutations in the TLR3 Cascade pathway NFKBIA IRAK2 NRAS RPS6KA5 MAPK14 MAP3K7 IL6 MAPKAPK3 IL6R MAP2K6 RPS6KA2 PMC7477231__F8 Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway MSC GC PTEN EZH2 ME3 HEL-S-68p PMC9565660__F1 Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis HEL-S-62p PMC7333666__F3 Role of YAP in the cytoplasm and nucleus regarding central nervous system disease SOCS2 ERBB4 NF2 STAT3 TEAD2 PMC8943788__F6 rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori–infected individuals: a genome-wide association study in the Korean population GC SPOP ZNF652 PMC6830101__F12 Graphical summary of perceived crosstalk of BMP2-mediated signaling and the NO pathway BMP2 SMAD4 SMAD1 DKFZp781O1323 PMC10341762__F1 One-carbon metabolism HEL-S-61p BAD DHFR MTRR MTHFD1 PMC6651320__F1 Schematic representation of MVA pathway SQLE DHCR7 DHCR24 HMGCR PMC9069407__F3 Generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation CMTM6 KPNA2 SPOP HEL113 STAG1 GSDMC STAG2 IFNG CMTM4 STAT3 PMC7565951__F2 Roles of TRIM proteins in pattern recognition receptors (PRRs)-mediated immune signaling pathway TBK1 USP15 IRF7 TRAF3 IRF3 TRIM44 TRIM25 MAVS PMC7235403__F7 Lysosome pathway in DEX-treated sarcoid AMs GNS SGSH GALNS CTSK NAGA ATP6V0D1 GAA GUSB TCIRG1 PRKCB AGA LIPA HGSNAT ABCB9 LITAF ACP2 GLA PMC7235403__F6 Effect of DEX on metabolic pathways in sarcoid AMs PIG59 AASS PPARGC1B UQCRFS1 MDH2 ALDH7A1 ACADS UQCRC1 ACO2 COX11 COX6B1 OGDH COX6A1 UQCRHL SDHD HK2 SDHA COX8A HEL-S-30 NDUFA6 ENO1 AOC2 HEL-S-87p IDH3B HEL60 ACAT2 NDUFA3 ACOX3 PMC4724610__F1 Systematic representation of microRNA biogenesis, deregulation and function AGO2 DGCR8 DROSHA RAN PMC12119277__F3 Mechanisms by which mediators of inflammation resolution regulate neutrophil apoptosis and survival ANXA1 BAD MPO APAF1 FPR2 MCL1 LGR6 GPR37 BAX PMC1851054__F6 SFK-dependent PI3K-ERK2 and phospholipase CG-JNK1 pathways HEL-S-62p HLA-E PAK1 VAV1 CD48 MICA RAC1 PMC12119277__F2 Neutrophil apoptosis APAF1 MCL1 BAX PMC3395736__F1 Glycolytic pathway and its metabolic interconnection with the pentose-phosphate pathway HEL-S-162eP PMC6412216__F5 Mediation of the maturation and activation of BMDCs during Mycobacterium bovis infection by the cGAS pathway TBK1 CGAS IRF3 IFNAR2 IFNAR1 PMC3639292__F3 Metabolic rewiring in melanoma engages more carbon than just glucose GPT PHGDH GLS PMC4628764__F1 Heme biosynthetic pathway in erythroid cells VIT STEAP3 SLC25A38 TMEM14C ALAS2 ABCB6 FECH UROD UROS HMBS CPOX ABCB10 SLC36A1 PMC5406702__F3 EGFR family members regulate autophagy affecting cancer cell survival and death TSC2 ULK1 LAPTM4B TSC1 ATG12 EGFR AMBRA1 UVRAG ATG14 PMC5777650__F6 Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy RICTOR PIR MTOR PMC2999286__F1 The involvement of the Unfolded Protein Response (UPR) signaling in lipid metabolism EIF2A TG XBP1 PMC5070725__F1 Schematic model of metabolic regulation by S6K1 in two ways TSC2 TSC1 WNT10A EZH2 WNT10B PMC6925592__F2 Smad7 Restricts DC Responsiveness to TGFB and Their Ability to Induce Tregs BAMBI RUNX1 MYC AMHR2 ENG ID1 SOX4 FOXP3 MLN FST GIG8 AMH INHA TOB1 EVI1 GSC EMP1 INHBA TGFBI PMC8510449__F6 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review BAD WEE1 ERCC1 CDK8 STAT3 PMC8510449__F5 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review ZEB2 EGFR CD44 CD24 PMC8306430__F3 Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation GABRG3 PIG59 GABRB3 C1QB SOCS3 HERC6 SHANK1 CIC GABRB2 PSMB10 PMC5220041__F5 Thyroid cancer-related signaling pathway relational graph BRAF MMP9 MTOR PMC7105005__F2 CGAS/STING-signaling through Post-Translational Modifications (PTMs) TBK1 CGAS ULK1 RNF185 USP20 MUL1 IRF3 SENP2 TRIM29 USP18 RNF5 AMFR INSIG1 TRIM38 RNF26 TRIM32 SENP7 TRIM56 PMC8510449__F7 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review WEE1 CCNB1 PMC3302314__F2 Left half, signaling via IPS-1 following dsRNA/ssRNA recognition by RIG-I and MDA5 NLRP3 TANK TRADD IRF7 TRAF3 IRF3 IL1B FADD PMC3302314__F1 Signaling cascade following TLR2/TLR4, TLR7/TLR8, and TLR3 activation with envelope glycoprotein, ssRNA, and dsRNA, respectively IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 PDC TLR7 TLR4 TIRAP TAB3 PMC6550017__F5 GLI proteins are regulated by PKA ARHGAP36 GPR161 SMO ADRBK1 PMC11004261__F5 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions CASP3 FOS CCND1 SRC BCL2 CDK4 BCL2L1 MTOR WNT5B JUN CCNE1 STAT3 PMC2925066__F1 Major Apoptotic pathways APAF1 DIABLO HTRA2 FADD BAX PMC6550017__F1 HH signaling SUFU EVC SMO PMC11004261__F4 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions MDM2 PMC6824835__F2 AKAP5 and AKAP12 in modulating oxidative stress in cardiac cells AKAP12 SMAD2 TGFBR1 TGFBR2 AKAP5 TGFB1 PMC11004261__F3 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions GSK3B DPYSL3 EZH2 PMC9453300__F3 Emerging role of different DNA methyltransferases in the pathogenesis of cancer PI3 BAD MDM2 PTEN PMC11994733__F1 Suitable concentrations of brassinolide application enhances growth performance and saikosaponin biosynthesis by transcriptional activation of triterpenoid pathway genes in Bupleurum chinense DC MVD MVK IPP PMC4977886__F4 Differentially expressed proteins regulated cellular processes/diseases and hypothetical depiction of BPA action PS1TP5BP1 SDHB PMC2720436__F1 Hippo pathway, a vital growth regulator of cell proliferation and apoptosis was initially identified by mosaic screens in Drosophila melanogaster (,) BIRC2 BIRC5 LATS1 MCL1 PMC8332859__F8 CR13626: a novel oral brain penetrant tyrosine kinase inhibitor that reduces tumor growth and prolongs survival in a mouse model of glioblastoma KL RET FYN PMC3223252__F7 A refined model shows MEHP-decreased TIMP2 expression in Sertoli cells is mediated by the inactivation of CEBPA and the activation of MYC and is dependent upon the FSH-stimulated cAMP signaling pathway MMP2 MYC CEBPA FSHR PMC3897272__F1 Eicosanoid biosynthetic pathway COX2 COX1 EGFR PMC11994733__F6 Expression of key genes in the saikosaponin biosynthesis pathway in B LBR IPP BRS3 PMC5462947__F4 Metabolic traits of KF-JG30-18 (A) and DA052 (B) as derived from the genetic potential of RH2 MAG 17b and RH1 MAG20 LIAS CIT MAL PMC4038253__F1 Simplified scheme of the N-glycosylation pathway RFT1 ALG2 ALG1 ALG3 ALG12 DPAGT1 MGAT3 ALG13 ALG6 ALG10 MGAT2 PMC8123211__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions SRC PARP2 PARP1 CCL2 CXCL12 CCL3 PMC8123211__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions AMOT PARP10 LRP5 CD44 LRP6 PARP1 RNF2 RNF146 HEL113 PARP3 PMC7062835__F1 Molecular network identified using the “Interaction search” algorithm in KeyMolnet SNCA GNB2 TUBB MAPK10 APC ALB MAPK3 MYC NAPB ARHA MAPRE3 PRKCA JUP HEL-S-67p PID1 MAPK1 GPD2 ADRBK1 GNB1 AK1 HEL-S-29 HPCA PMC6276090__F4 Signaling pathways in osteoclasts involving V-ATPases CSF1R LRP5 TRAF6 LRP6 RHEB PMC6627782__F3 mTOR signaling in spermatozoa from older men RPS6KB1 MAPK8 AKT1S1 RPS6 DEPTOR MLST8 PMC9659959__F1 Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome TBK1 TLR8 TLR7 TLR9 IRF7 UNC93B1 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC6627782__F2 Network of the sperm proteins differentially associated with male age MYH9 BAD MAPK8 HSPA2 GSK3B ANXA3 MAPK14 AKT1S1 HEL-S-7 MYH10 MTOR ACTL9 S100A6 CLU MAPK12 CCT7 DCXR RPS6 PATE1 PFKP HSPA4 FASN HEL-S-130P CASP3 HEL-S-102 YWHAQ RPS6KB1 MAPK13 HEL-S-269 MAPK11 TTLL12 AKT3 PMC5564615__F7 Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway MDM2 SP1 PMC2995824__F1 Regulation of muscle protein synthesis TSC2 RICTOR TSC1 PRR5 EIF4E MTOR DEPTOR RHEB PMC3786361__F1 Epidermal growth factor receptor family and targeted agents EGF BTC EGFR HBEGF TGFA PMC9597983__F2 Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential BAD CDK2 EGFR NANOS1 BNIP3 IGFLR1 INSR BAX PMC3829478__F9 Wnt3a binds to Fz7 and cross-activate the IGF-1-PI3k-Akt pathway inducing initial axonal outgrowth and neuronal polarization WNT3 IGF1R WNT3A FZD7 PMC4772995__F2 Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients GAS2L1 OAS1 DRAP1 HLA-G DHX58 NOMO1 DNASE2 SPCS2 RFXANK NCLN ARHGEF10L PMC22365__F5 Evolutionary conservation of the DNA damage and the replication checkpoints CDS1 ATM ATR PMC7844014__F6 Network of interactions significantly enriched for genes displaying altered methylation patterns following treatment with valeric acid RIT1 MUC1 PRCC ATG16L1 ATG12 NASP CTNNA3 FKBP3 MOV10 DHX16 SREK1 FYTTD1 TRAPPC6B ZNF317 HMMR DDX39B SAFB TRAPPC12 PMC6497933__F6 Summary of the DEPs involved in central carbon metabolism and fatty acids synthesis FRK CIT MAL PMC2843167__F7 Summary of the findings presented here HDAC2 PCNA PMC4223335__F10 Concerted regulation of NFATc3 by electrical activity and NGF in sensory neurons NGF GSK3B NFATC3 PMC5831770__F1 Sonic hedgehog signaling pathway SUFU PTCH1 GLI3 SHH SMO PMC6003838__F2 The spatio-temporal cell dynamics of the G-protein/Pth11 and cAMP-signaling pathway during surface sensing and appressorium morphogenesis RGS1 PMC4090390__F2 Metabolic fluxes, NLRP3 and IL-1B NLRP3 TLR4 IAPP PMC4669123__F1 Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish DGAT2 ACOX1 FASN PMC4090390__F1 Pathogenesis of T2D: adipose tissue, the pancreas, NLRP3 and T2D IRS1 IL1B IAPP PMC4957946__F1 Differentiating mTOR Inhibitors in Renal Cell Carcinoma EGF EEF2K IGF1R EGFR VHL PTEN EIF4E MTOR RHEB MLST8 TSC2 RICTOR TSC1 IGF1 EIF4B PMC5649368__F3 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors EGFR SRC DES EZH2 PMC5649368__F1 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors GC SP1 PMC4824563__F3 Network analysis ABL2 PLK2 EFNA1 STRN3 AIRE TRIB2 ENG ID1 HMOX1 CEBPD GBP1 TNFRSF1B MBNL2 TAP2 BIRC3 HEL-75 DUT MTDH TM4SF1 IRF-1 ACSL3 RHOB SOCS1 TRIO PMC6992624__F3 An integrated computational and experimental study to investigate Staphylococcus aureus metabolism ME1 ME2 CS MALL GIP ASPA TNLG7C NDP THRA PC PGC RPE MAL PMC9319476__F2 Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta APC DKK1 PMC9580404__F3 Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis TGFBR1 REST IL1R1 JAK3 PMC8585775__F7 Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity HEL-S-269 HEL-S-99n IFNG PMC5572303__F5 Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins EGF F2R FLNA ABI2 DOCK1 HEL114 CRK PXN GNG12 PMC3413225__F7 Model describing the mechanisms of quercetin-induced cholesterol efflux in macrophages GC ABCA1 SP1 PMC3570300__F5 Ingenuity Pathway Analysis of proteins induced by DNP.A, overview of 15 specific functional networks, each of which contains 11 or more “focus” proteins (proteins that were significantly up- or down-regulated) PLAUR HEL-S-84 IGF2 EGFR MDC1 SBDS DGAT1 MTR SNCG HTATIP2 NDUFB8 MMP2 ITGA6 SATB1 FXR1 TP73 BCL2 EXOSC10 RP2 PXN STAT3 PMC7697665__F2 Role of RNF11 in the transforming growth factor beta (TGFB) signaling pathway RNF11 SMAD2 SMURF2 SMAD4 WWP1 SMURF1 ITCH PMC3914023__F3 A model of the EZH2 functional switch from a polycomb repressor to a transcriptional activator in castration-resistant prostate cancer SET REST EZH2 SUZ12 EED PMC6829404__F8 Leptin-induced EMT via Src and FAK signaling pathways EGF EGFR SRC PMC3527145__F1 The left-right asymmetry pathway NODAL PITX2 LEFTY2 PMC6539494__F4 Single-Cell RNA-Sequencing Identifies Activation of TP53 and STAT1 Pathways in Human T Lymphocyte Subpopulations in Response to Ex Vivo Radiation Exposure MYC PMC3690365__F2 Pathways that control levels of macroautophagy ATG12 MTOR ATG14 DKFZp686F0183 PMC6708273__F6 Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic Beta-Cells to Type 2 Diabetes MYC GRB2 MTOR MAFA PMC5209821__F4 Working hypothesis of the mechanism through which different miRNAs regulate the PTEN pathway, PI3K/AKT and STAT signalling in sperm CASP3 GYS2 PIM1 MYC BCL2 GYS1 PTEN RAF1 JAK1 MTOR PMC8616451__F1 Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells MRGPRX2 IL33 MYD88 PMC9369061__F1 JAK/STAT Pathway and Its Selective Inhibition in the Treatment of Atopic Dermatitis: A Systematic Review STAT1 IL13 IL22 TYK2 JAK3 IL31 JAK1 IL4 IL5 TSLP STAT3 PMC8497618__F8 Proposed model of how Enpp4/S1pr5 controls pronephros patterning ENPP4 WNT4 S1PR5 PAX8 PMC5564786__F6 MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3B/E-cadherin pathway GSK3B PMC6115855__F7 Anti-cancer mechanism of the PEC treatment in both AGS and MKN28 cells EIF4E CDC2 MTOR PMC11884773__F1 Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function TRPA1 TRPV1 TRPM8 PMC7542154__F3 Immunoregulation of PD-L1/PD-1 in GBC ERBB2 ERBB3 EGFR MTOR PMC5711031__F10 Interleukin-1beta (IL-1B)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1B on human dystrophic myogenic cells IL16 CSF3 CSF2 NOTCH3 IL1B PMC8452392__F7 Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking PIM1 EGR1 MMP2 SMAD2 SMAD4 CDK4 TF SELE CPD BAX PMC4802778__F2 Role of sortilin in EV biogenesis RAB27A TES PMC3608394__F6 Enriched pathways and GO functional annotations are: (a) ErbB signaling pathway: p=9.10e-13; Signal transduction p=2.33e-07 NOTCH2 ANGPT2 PTK6 PSEN2 HEL-S-1 EGFR INS MFNG NOTCH3 GRB7 INSR POFUT1 NOTCH1 SRC PPP2CA SNW1 THBS1 SH2B1 SHC1 PMC8624197__F3 Bioconversion of Lignocellulosic Biomass into Value Added Products under Anaerobic Conditions: Insight into Proteomic Studies HBD PMC3608394__F5 Subnetworks identified from TCGA ovarian cancer gene expression data set HEL-S-1 NRAS MYC LFNG RB1 BRCA1 AURKA DMPK GNG4 CREBBP TBP MAX APP SRC RAD51 PMC8548690__F6 Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can IL17A TNF ACE2 PMC3608394__F7 Enriched pathways and GO functional annotations are: (a) NFKB signaling pathway p=7.03e-05 NOTCH4 UBE2D3 GSK3B SMAD4 NCOA6 CAMK2G RSF1 CEBPB IKBKB NFKBIB CREBBP NFKB1 UBE2I TOB1 PRKAR1B FOXH1 PMC8539121__F1 In Vitro Analysis of Deoxynivalenol Influence on Steroidogenesis in Prostate CYP11A1 HSD17B3 CYP17A1 STAR PMC11010822__F7 MTA1/mTOR pathway in prostate cancer CCND1 MTOR PMC2409614__F3 Development of tamoxifen (TAM)-resistant breast cancer and the changing role of oestradiol (E2) in the life and death of ER-positive cancer cells EGFR FADD PMC2601665__F1 Hh-Gli pathway and the Gli code in tissue patterning and stem-cell lineages NUMB REN SUFU PTCH1 GSK3B SMO ITCH PMC3148240__F1 Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin EGF EGFR SRC ARHA PTEN PMC8857760__F3 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights APAF1 BAX PMC8857760__F2 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights HMGB1 TLR5 MYD88 PMC3517080__F5 Putative Altered Signaling Events occurring upon treatment of GSI MYH9 PA2G4 GFAP PCNA PMC4657516__F5 Antioxidants in Translational Medicine MAF KEAP1 PTEN PMC9289522__F1 Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis NLRP3 TLR4 IRAK4 MYD88 PMC8815087__F4 Phosphodiesterase 1 (PDE1) regulated cAMP and cGMP signaling pathway in cancer and neurological disorders PDE1B CNP NACA2 UHRF1 BDNF PMC9142082__F1 Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing WRN PNKP APLF PAXX PMC4155268__F5 The cytoprotective signaling of EPCR-APC APC ARHA RAC1 PMC11674240__F2 TRIM proteins in the signaling pathways TRIM11 TRIM16 TRADD SMAD2 APC TRIM21 SMAD4 TNF TRIM29 TRIM25 TRIM59 TRIM65 TRIM40 TRIM14 TRIM52 TRIM32 TRIM50 TRIM58 TRIM28 TRIM24 TRIM44 TRIM47 FADD PMC3976840__F2 FASN related metabolic and signal transduction pathways ACACA PTEN ACLY FASN PMC8826578__F3 Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases CDK14 CDCA3 CDC42 PMC8579148__F4 Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease TSC2 EGF ULK1 TSC1 IGF1 SRC DKFZp686F0183 RHEB PMC8618147__F6 Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease STAT1 NLRP3 TFEB STAT2 IRF9 TRAF3 ACE2 IL1B PMC8231629__F3 Impact of Hydrogen Peroxide on Protein Synthesis in Yeast EIF2A EIF4E EIF4B PMC4104069__F2 Pathways to Tumorigenesis and Persistent Infection TLR4 IRAK1 IRF3 MYD88 TLR3 PMC2668926__F1 EGFR Signaling Pathway GRB2 CCND1 CDK4 CDK6 PMC8831132__F1 NAD+ in COVID-19 and viral infections NAMPT PARP1 SARM1 NRK HEL-S-5 PMC8665869__F5 Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling NLRP3 AIM2 IL1B STAT3 PMC7813757__F1 Mechanism underlying the role of TLRs in tumor immunity TLR5 TLR7 TLR4 TLR9 TLR1 PMC5349223__F6 Regulation of Posttranslational Modifications of HMGB1 During Immune Responses HMGB1 TRAF6 ECSIT MYD88 TIRAP PMC8929128__F1 Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients CYP27A1 NR1i1 CX3CL1 FAIM PMC2875058__F2 Several disease pathways involved in AD pathogenesis BACE1 SORL1 PSEN1 CALHM1 PICALM CR1 APOE CLU PMC5493925__F3 Regulation of the zebra finch RLR pathway TANK CYLD IFNE IRF3 TRAF2 FADD PMC8174116__F5 Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer DGIC KIF23 MLPH F8 FOXQ1 PCDH7 ITGB6 EPB41L4B DKK1 SLC4A4 NQO1 ITGA2 SDR16C5 PAIP2B ABHD17C COL12A1 TMC7 PGM2L1 C2CD4B MCOLN3 PKHD1 SCEL FGD6 BTG2 NR3B3 CCDC141 ATRNL1 KCNJ16 UNC79 ADAM9 VCAN NRCAM GLS2 MTMR11 FREM1 GABRP COL5A2 AHNAK2 DPP10 TMEM97 EDNRA MMP14 THBS2 LMO7 ST6GALNAC1 OLR1 BACE1 LONRF2 NR5A2 COL3A1 ESM1 HEL-S-116 PROX1 INPP4B FLRT2 HEL-S-104 COL1A1 REG3G NRP2 CD109 ANGPTL1 NPR3 IGF2BP3 SCGN SCG3 SLC7A2 SLC1A2 GJB2 ADAM28 FNDC1 EPHA4 SV2B SLC16A10 MMP9 MATN3 SLC30A8 ASAP2 RTKN2 PDK4 IGFBP5 IAPP ADHFE1 DCDC2 TNS4 ACADL NR4A3 TRHDE PMC7831039__F1 mut-p53 alters the communication of tumor cells with their microenvironment TBK1 CXCL10 DGKA APPL1 PMC10407612__F8 Ghrelin in promotion of ADMSCs cardiomyocyte differentiation SFRP4 GATA4 PMC11810460__F3 Schematic representation of cellular targets of HDACi and targeted BRAF mutant therapy concepts of relevance for cell death mechanisms BRAF SLC7A11 IMPACT GRB2 MTOR PMC4866972__F1 Intrinsic and extrinsic pathways of apoptosis TRADD DIABLO TRAF2 FADD BAX PMC4866972__F3 Principal cell death pathways involved in intervertebral disc (IVD) degeneration TSC2 TSC1 BNIP3 MTOR DIABLO FADD RHEB PMC6710443__F10 Schematic diagram of the mechanisms about the role of HDAC3/NF-kappaB pathway in pathogenesis and exercise therapy of OA ADAMTS5 HDAC3 IL1B PMC3303591__F1 Stimulation of PI-3K/Akt signaling pathway after activation of IR/IGF-1R mediates insulin neuroprotection against damaging conditions GSK3B GPX1 PMC2529154__F4 Four components to yield MDP chromophore HEL-S-62p C7 C6 NDP PMC6378136__F2 Endosomal sorting and trafficking, the retromer complex and neurodegeneration BACE1 VPS35 APP PMC5572632__F2 Salvianolic acid B protects against diabetic atherosclerosis via the Nrf2 signalling pathway MAF KEAP1 NQO1 PMC5483877__F1 Strategies of effective targeting of hepatocyte growth factor (HGF)/c-Met signaling for the prevention of hepatocellular carcinoma (HCC) PI3 HGF PMC8741925__F7 Mechanical stress dampens the CR, resulting in the degeneration of IVDs through the Rho/ROCK pathway MMP3 ADAMTS4 MMP9 ARHA PMC3952039__F1 To Bud or not to Bud: The RET perspective in CAKUT RET GDNF SRC PMC3063605__F1 Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NFKB activation and some of the key receptors, adaptors, and kinases involved TLR5 TLR4 TLR9 DAP MYD88 TLR1 PMC5572632__F1 NFKB signalling pathway is involved in the diabetic atherosclerosis PC TRIB3 IRS1 PMC3271045__F4 Schematic summary of striatal gene expression changes in response to SNCA overexpression HEL111 SYN2 DHCR24 CARTPT DRD2 BDNF MEF2C PMC4465570__F3 Genome-wide association study points to multiple loci predicting antidepressant treatment outcome in depression PON2 MYBL2 PTPRK PTGER4 HAS2 RYR2 HEL-S-22 PTPRS APOB TNFRSF1A TNFRSF21 EPHX2 CD36 PMC10454149__F1 MiRNA-146a—A Key Player in Immunity and Diseases CD14 TLR5 IRAK2 TRAF6 MYD88 TLR1 PMC8193053__F9 Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages NLRP3 CD14 TLR4 IRAK1 LBP TRAF6 IRAK4 MYD88 FADD PMC6770479__F1 Molecular mechanisms involved in inflammasome activation NLRP3 IL16 NLRC4 NLRP1 AIM2 GSDMD PMC6770479__F3 Chemotherapy-induced apoptosis and pyroptosis in cancer cell FADD BAX DFNA5 PMC3514612__F7 Synthesis of nitric oxide and transduction cascades ARC BDNF PMC10454149__F3 MiRNA-146a—A Key Player in Immunity and Diseases IKBKB NFKBIA CHUK TNIP2 EP300 NFKB1 RELA RELB MAP3K8 REL HDAC1 PMC3533650__F10 Regulation of the FOXO3a survival, and glycolysis pathways under hypoxia in Spalax MYC PTEN MTOR HEL-S-133P HK2 CITED2 PMC10454149__F2 MiRNA-146a—A Key Player in Immunity and Diseases TRADD TRAF3 TRAF6 MYD88 BTK TLR4 BCR ATM BASH CYLD CD14 KCP LTB PARP1 RALB TNF TRIM25 EDAR LTA LBP CD40 SYK LTBR LAT TIRAP PMC6904929__F2 MicroRNA Mediated Regulation of Immunity against Gram-Negative Bacteria TLR4 TLR9 TRAF6 MYD88 PMC9038741__F5 Metabolic reconstruction of Angelarchaeales-1 genome HP CIT MAL PMC6478758__F3 Pervasive regulation of TLR signaling pathway by miR-146a/b family and miR-125a~99b~let-7e cluster TLR4 IRAK1 TRAF6 MYD88 TNF STAT3 CCL3 PMC8870611__F2 Prognostic and Predictive Molecular Markers in Cholangiocarcinoma EGF SOCS3 HGF EGFR MTOR FGFR2 STAT3 PMC5030800__F10 The regulation of lysosomal biogenesis and autophagy by cathepsin B in response to infection with F ULK1 TFEB MTOR PMC4698384__F3 Downstream gene targets of predicted cytokine and transcriptional regulators HLA-E MARCKS CTSS THBD FCGR2A POSTN EMP3 CD74 HLA-DMA IFNG MRC1 DCN COL14A1 CFD WEE1 GBP2 NOTCH1 TBX5 SERPING1 CNN2 IL1B IL10 MGP ADAMTS5 XLKD1 LCN2 UGDH CEBPA TNF CYBB HLA-DRB1 GAST IRS1 NFKBIA TNFRSF1B GIG8 SPI1 HLA-DQA1 DBP SOAT1 ACP5 IGFBP6 MEF2C PER3 CASP4 STAT3 PMC7056466__F1 Hydroxytyrosol (HT) and its main biological actions STAT3 BAX PMC4336643__F8 Proposed signaling pathway NR1i1 UNK JUN PMC3436686__F6 Ensemble representation of EGF signalling network EGF PRKCZ EGFR MAPK3 PRKCA PTPN11 SRC MAPK1 ARAF JUN FOS HRAS PRKD1 SPRY2 CBL ITGB4 MAP2K1 GRB2 BCL2 HEL113 RAF1 GRB10 SOS1 SHC1 PXN PMC3186711__F8 A model of the role of TLR4 signaling pathways in regulating TNFA expression TLR4 MYD88 TNF MAL PMC4046345__F2 dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects TBK1 TRAF3 TRAF6 IRF3 TRAF2 MAVS BAX PMC5601671__F6 The apoptotic signaling pathway of microRNA-155 in splenic lymphocytes TNFRSF1B BAX PMC11755087__F2 Schematic diagram showing insulin pathway in C SGK1 PMC4985526__F1 Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy PI3 EGFR TGFBR1 TGFBR2 SMAD4 PTEN MTOR PMC4044299__F4 TG2-mediated adhesion/signaling at the cell surface SRC ARHA PMC4655955__F1 IPA prediction of the interactive network between the differentially expressed genes in the blood of triple negative compared to ER/PR+ breast cancer patients.Notes: Red – genes overexpressed; Green – genes underexpressed CXCL13 IL16 CCL26 IFNA2 TNFSF13 OSM PMC6566669__F1 Set of motor neuron proteins in the MAPK signaling pathway MAX GRB2 JUND RAF1 CDC42 PMC12068639__F2 TRIM proteins positively regulate innate immune signaling pathways TBK1 CGAS PIN1 STAT2 IRF7 IRF9 TRIM21 TRIM8 IRF3 TRIM4 TRIM25 TLR3 TRIM65 STAT1 TRIM14 TRIM38 TRIM56 TYK2 TRIM10 JAK1 TRIM5 PPP6C MAVS PMC9319447__F4 Identification, Characteristics and Function of Phosphoglucomutase (PGM) in the Agar Biosynthesis and Carbon Flux in the Agarophyte Gracilariopsis lemaneiformis (Rhodophyta) PTS STS GLA PMC4765060__F5 Canonical pathway analysis CHUK CASR TRO RRAS HRAS DIABLO HTRA2 MAPK4 RELA TNFRSF1A TNFRSF18 CAD CYCS PMC4051169__F8 Mitotic roles of Polo-like kinase pathway CDC20 POLE WEE1 APC SLK PTTG1 FZR1 MYT1 PMC3415586__F2 Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity CD40 IRF4 PMC4931361__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention MCL1 FADD BAX PMC6712451__F5 Subnetworks of special pathogenic pathways corresponded to different metastasis lesions EGF NCOR1 TNRC6A AGTR1 EGFR SMAD2 NRAS MYC SMAD4 ASH2L GATA1 ERBB4 THBS1 RNF111 RBL1 TNRC6C KAT2B RUNX3 RUNX1 GFAP HBEGF NRG1 FZD4 HRAS CFTR KMT2C APOB LEF1 ERBB2 TGIF1 KMT2B MLL2 AGFG1 PMC6109778__F3 Simplified ketone body metabolic pathway ACAT1 ACSS1 ACADS HMGCL BDH1 ACSF2 ECHS1 PMC11117695__F9 MAs protect IPEC-1 cells from H2O2-induced oxidative stress, inflammation and tight junction protein disruption via activating the Nrf2 pathway to inhibit the ROS/NLRP3/IL-1B signaling pathway NLRP3 SFN TNF NQO1 PMC4445654__F1 Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis REN AGTR1 EGFR HSD11B1 CYP21A2 AGTR2 RNPEP DPP3 MAS1 CTSA AKR1C4 CMA1 CYP17A1 ACE2 KLK1 CYP11B2 ENPEP HSD11B2 CYP11A1 HEL-S-130P CTSG AKR1D1 NLN LNPEP THOP1 MME IGF2R PMC1664647__F1 Schematic representation of the Fas pathway used in the mechanistic model CASP3 CASP6 CASP8 PMC6918121__F1 Molecular composition, biogenesis, secretion, and uptake of the exosomes TSG101 CD9 CD63 CD82 CD81 PMC5343412__F7 Phylogenetic relationships of algae thiorredoxin-like ferredoxin domains SRM ROS1 PMC8082066__F7 SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease CDK4 CDKN2A SIRT1 TET2 PMC6280608__F6 The search page of prescription category as seen by submitting different names REN PMC2712749__F1 T cell receptor signalling canonical pathway obtained by IPA obtained in comparison MM8_PM8 IMP3 LAT PMC6280608__F2 The shared targets and pathways in Yu Ping Feng SHD APP LAT PMC9204954__F2 Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia ASMT GCA TPH1 KYNU KMO AANAT PMC4826167__F2 The role of the oncofetal H19 lncRNA in tumor metastasis HMGA2 EZH2 PMC8196589__F1 Estrogens and Progestogens in Triple Negative Breast Cancer: Do They Harm? EGFR SRC PMC4837658__F1 Mouse T cell development MYB KIT RUNX1 ATL1-beta ERG ID3 HES1 LEF1 LYL1 IL7R GFI1 FLT3 ETS2 LMO2 GATA3 PMC9513977__F5 Mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress HEL-S-61p PIPOX CHDH AGXT2 PMC4696971__F2 NOD-Like Receptors in Infection, Immunity, and Diseases NLRP3 NAIP ATG16L1 NOD1 NLRC4 NLRP1 NLRP12 NLRP2 TRAF6 MYD88 NLRP7 NOD2 PMC2847023__F3 Vitamin D3-driven signals for myeloid cell differentiation - Implications for differentiation therapy CD14 NR1i1 EBP PMC8869775__F1 Assays Used for Discovering Small Molecule Inhibitors of YAP Activity in Cancers LATS1 MOB1A MOBKL1A LATS2 PMC8065657__F1 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor signaling in the regulation of apoptosis and metastasis of cancer cells RIPK1 SRC SPHK1 RAC1 TRAF2 FADD STAT3 PMC7199609__F2 Noncanonical functions of MAPK are emerging targets for BRAFV600E-mutated cancers CGAS BRAF PIR PMC5830368__F2 Current evidence for extracellular vesicle crosstalk in the homeostatic bone marrow microenvironment ANGPTL3 ANGPTL2 VCAM1 MSC TPO PMC12146543__F4 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of cerebral ischemia and reperfusion (CI/R) GPX1 HEL-S-44 GAP43 BAX PMC12146543__F3 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of neurodegenerative disease ATG12 APP MTOR DKFZp686F0183 BAX PMC101920__F1 Late steps of AdoCbl biosynthesis in S ME2 APP PMC4641948__F2 Thrombin effects in endothelial cells involve S1P signaling SPHK1 RHO SPNS2 PMC6803569__F4 PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules TWIST1 BCL2 CDK4 EZH2 HEL-S-133P HK2 BAX PMC7198842__F3 Chronic phase-CHIKV mediated joint pathology: in the joints, osteoblast cells (Bone-forming cells) are susceptible to CHIKV infection causing over-expression of IL-6 and RANKL and inhibition of osteoprotegerin (OPG) FRK TRAF6 CCL2 PMC3402799__F2 Networks generated by Ingenuity Pathway Analysis of the expression signature CUL5 PTGER2 CORT NAGK SQSTM1 IRAK2 SMAD2 SYT3 GPR176 AMH ABCC9 HTT BMP8B KCNJ15 SV2B PDZK1IP1 VAPB NAALADL1 DNAJC5 SLC6A9 SSTR3 PTGER4 DACH1 MAP2K2 IL6 SLC22A4 TNF VAMP1 SSTR2 SSTR5 SMAD9 CLCN3 ASGR1 YWHAQ SLC17A1 ASB2 ACVR1B CRTC2 SLK HSPA1A CPLX2 PMC5719148__F1 Models for post-translational control of CHMP5 during T-cell development CHMP5 BCL2 PMC7920452__F4 Representation of the gastrointestinal signaling pathway SOX2 CCL26 KLK5 ERBB3 RXFP3 CYP24A1 FGFR4 DLL3 KRT6B CCNE1 ADRA2A DAB2IP KLK3 CCL27 KRT14 PMC4571319__F1 ERRs are key transcriptional factors that regulate cellular energy metabolism SLC2A12 CS ENO1 COX7A2 HEL-S-162eP SLC2A4 SLC2A2 ACO2 UQCR10 OGDH COX6A1 HEL-S-133P HK2 ACADM HEL-S-281 SDHB PMC11019495__F3 Recent advances of nanoparticles on bone tissue engineering and bone cells BMP3 RUNX2 BMP2 PMC7920452__F3 Representation of the dermatological signaling pathway CLSTN2 TPSD1 RGS4 CCL21 IFNL1 STAP2 NCR2 TACSTD2 MCAM SLC52A1 ELF3 SHBG TYRO3 CXCL6 EMP1 KRT10 PMC5574901__F2 Most significantly relevant pathways and highly linked molecules (identified molecules from 17 preclinical studies which to explore the potential mechanisms of TLs for pancreatic cancer) relevant to the merged bionetwork MAP2 SMAD2 VEGFA DKK1 TNF MTOR CHEK1 DDIT4 ID3 HEL55 HES1 MAP2K1 TGIF1 ETS2 SP1 PMC8773784__F2 Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New Therapies NLRP3 CXCL5 NLRP2 IL1B PMC6628503__F6 Proposed model of gga- miR-1306-5p regulation on activation of pro-inflammatory responses via targeting Tollip in chickens (Red arrow: up-regulation or down-regulation) IRAK1 IRAK4 MYD88 IL1B PMC8269128__F3 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences MYF5 PAX7 MYOG PMC8658031__F4 Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19 NLRP3 IL18 TRAF3 ACE2 ADAM17 PMC8269128__F4 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences HEL-S-30 BCL2 ENO1 BNIP3 HK2 HEL-S-68p HEL-S-162eP PMC3642384__F2 Hypothetical evolutionary and functional relationship between Beta-catenin and nuclear transport receptors LRP5 LRP6 RAN PMC9569508__F3 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity HPD POLL RHEB POLI PMC9569508__F4 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity REL tal-1 FADD PMC3893888__F4 Signal transduction pathways leading to increased HIF-1A protein levels TSC2 TSC1 RHEB PMC5622284__F4 Upregulated genes involved in apoptosis signaling at 1 day after a single dose of 2 Gy Fe ions BAD LTA TRADD FES MYC MCL1 SP3 PMC3724057__F7 MOMA analysis identifies double-gene knockouts in primary metabolism that funnel carbon toward DHA CIT MAL PMC5622284__F6 Irradiated ECs differentially expressed proteins after X-ray exposure involved in caveolar-mediated endocytosis and cell-cell adhesion PTPN1 ARF4 TLN1 CDH2 PFN1 FLOT2 PMC7400218__F5 Cervical cancer in low and middle-income countries TLR4 TRAF6 IRF3 RAC1 MYD88 TNF PMC139817__F7 Regulatory interactions between SRF and TCF SRI RHO GAL PMC3498232__F9 Expression Profile in Rice Panicle: Insights into Heat Response Mechanism at Reproductive Stage MYB GDI2 ERF PRX PMC5622284__F2 Upregulated genes involved in cell cycle regulated processes at 7 days after a single dose of 2 Gy X-rays CCNA2 E2F4 HDAC3 E2F6 PLK1 HEL-S-1 SMAD4 TFDP1 E2F3 UBE2S SMC1A POLA2 MDM2 HDAC2 CKS2 APC SPAG5 MCM3 HMGA2 YWHAQ MCM2 ATR TGFB1 PCNA HEL2 CCNH CCND3 ORC3 ORC2 CCND2 ATM E2F2 MEN1 CCNB1 YWHAG NDC1 PRKDC RBL1 CCNE2 MYBL2 UBE2F HDAC7 ARF1 HDAC1 AURKA PTTG2 CCNB3 EP300 CCNB2 MPEG1 HEL-S-93 SKP2 PMC2635620__F2 Inhibition of each signaling molecules by natural products in insulin signaling SRC PTEN MTOR PMC6526932__F1 Targeting cancer vulnerabilities with high-dose vitamin C TF HEL-S-162eP PMC4365328__F1 HA precursors biosynthesis and main HAS2 regulation in SMCs OGT UGDH GIP HAS2 PMC4611209__F1 Sporadic traditional/CIN/suppressor pathway: sequential pathological stages and molecular events APC FAP PMC7981899__F1 Chemokines and their receptors’ roles in acute lymphoblastic leukemia MMP9 MYC ARHA RAC1 CXCR3 ZAP70 CCR7 NOTCH1 SRC CCL19 CCL25 CXCL12 STAT3 PMC5408584__F5 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias NAAA FAAH NR1C1 RXRA PMC5408584__F4 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias NAAA CPT2 FAAH NR1C1 RXRA PMC4235722__F2 Conservation between the Drosophila and the mammalian JAK/STAT pathway and their commonalities in inducing systemic and localized immune response and tissue growth SOCS3 IFNAR2 IFNAR1 IL6R PMC3782367__F1 Unfolded protein response (UPR) is activated in the autosomal dominant retinitis pigmentosa (adRP) retina and proposed to be a target for modulating the rate of retinal degeneration CRX NRL ATF4 BIK EIF2A PARP1 RHO MTOR TRAF2 PMC8897452__F6 Colorectal liver metastasis: molecular mechanism and interventional therapy NOTCH2 NOTCH4 NUMB MSI1 CD44 NOTCH1 NOTCH3 PMC11552248__F1 Adhesin RadD: the secret weapon of Fusobacterium nucleatum MMP9 TIGIT PCNA PMC8897452__F7 Colorectal liver metastasis: molecular mechanism and interventional therapy SMAD2 CXCR4 SMAD4 STAT3 PMC4671959__F7 Mechanism of the Redox-Dependent Brf2 Blockade during Oxidative Stress and Carcinogenesis, Related to , , , , , , and During normal growth conditions (A) Brf2- and Nrf2-dependent transcripts are synthesized at basal levels BRF2 TBP HEL-S-8a PMC5454446__F2 ‘Eat-me' signals, phagocytic machinery and signaling pathways GULP1 MEGF10 RAC1 MERTK STAB2 PMC6964096__F4 Wiki pathway analysis of the differentially expressed proteins (DEPs) during rhesus hippocampal aging MYB GNG7 RPS7 RPL35A RPL12 RPS19 RPS4Y1 RPL23 SDHD NTRK2 SDHA SDHB SDHC CES1 SOS2 NDUFB9 FGF12 RPL18A TSC2 GYS2 RPS6KA1 ND4 RPLP1 GNB1 RPL22 EIF4E1B RPS5 RPL26 NDUFB6 RBL2 RPS14 NDUFS6 NDUFV2 NDUFA7 STXBP1 NDUFAB1 NDUFS3 RPL4 RPS11 COXFA4 RPS9 PIK3C2G RPL8 GNG12 GSTM2 ND6 RPS17 ND3 RPL28 ND2 NDUFA10 RPL27A RPS21 RAB14 GSTA4 RPL7A PRKAA1 BCL2L1 RPL13 RPL19 RPL23A NDUFV3 ZNF183 NDUFS1 NDUFB8 GSTM3 NDUFS8 RAPGEF1 NDUFS4 GSTM5 HEL-S-310 LAMB2 RPL30 EIF4E HRAS RPS16 NDUFC2 RPS10 RXRA RPS13 NDUFB7 NDUFB3 TNR ITGAV RPS3 GNB4 RPLP2 CHUK HSP90AB1 SLC7A11 ND4L RPL27 GNG10 PTEN MTOR RPTOR INSR RPS28 NDUFB10 RPL10A RPS6 EIF4B RPS12 RPL34 RPL13a PRKAA2 FTH1 NFE2L2 FTL NDUFB2 MRPL19 RPL15 NDUFA2 NDUFB4 LAMB1 NDUFB1 ND1 NFKB1 NDUFA3 RELA NDUFC1 PMC3653945__F6 Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis IRAK1 FOS TRAF6 IRAK4 MYD88 TLR1 JUN TIRAP PMC9588339__F5 Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation TRAF3 INS TRAF2 PMC6724083__F2 Hypothetical network of metabolism in F CS FH GLS PMC7770494__F33 International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function NF1 TSC2 TSC1 CDK5 CDC42 PMC4224695__F3 Interactions of Acvr1b with other proteins in primary infection IKBKE ACVRL1 SMAD2 TEP1 PSMA2 RBM3 NACA WWP1 HSF1 CBL RS1 PLRG1 ACVR2B SHBG SART3 SNX2 MDM2 HEL113 TUB PCBD1 STAT3 SNX1 OPA1 VTI1B PMC7097117__F4 ISG15 in antiviral immunity and beyond ISG15 HERC6 TRIM25 USP18 PMC3311926__F1 Mitochondrial regulation of apoptosis BAX PMC5490213__F5 Representation of secondary metabolic pathway genes and tissue specific expression in response to MeJA and wounding in Bacopa monnieri CAD IPP HMGCR PMC7097117__F1 ISG15 in antiviral immunity and beyond TBK1 CGAS HERC6 IRF7 IRF9 ARIH1 IRF3 IFNAR2 IFNAR1 TRIM25 IFNLR1 USP18 ISG15 CREBBP TLR4 TYK2 JAK1 MAVS PMC5709539__F1 Emerging mechanisms underlying astrogenesis in the developing mammalian brain NEUROG1 GFAP PMC5993950__F2 DYSREGULATION OF mRNA TRANSLATION AND ENERGY METABOLISM IN CANCER ELF2 EEF2 PTEN EIF4E RPS6 EIF4B RHEB PMC3743503__F8 GeneGo pathway map translation regulation of eIF2 activity ELF2 EIF2S1 EGF EGFR EIF2B5 GRB2 HRAS EIF2AK1 DYRK2 PMC8122391__F3 Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma BAD MDM2 SYK STAT3 PMC3743503__F9 Evidence for indirect influence of kinases on tau phosphorylation PLK3 CDK2 MAP2K3 SP1 EIF2AK1 PMC8059748__F1 PI3 kinase signaling pathway TSC2 BAD TSC1 PTEN MTOR RHEB PMC8100938__F3 Platelets orchestrate the prothrombotic immune response in venous thrombosis HMGB1 IL18 VWF IL8RB TF PMC4918253__F2 Canonical and noncanonical pathways of inflammasome activation.Notes: (A) Canonical inflammasome activation (canonical pathway) TLR4 IL1B PMC6365678__F7 CXCL16/CXCR6 interaction promotes endometrial decidualization via PI3K-PDK1-AKT-Cyclin D1 pathway CXCL16 IGFBP1 TRO CCND1 CXCR6 PRL PMC5419541__F3 Signaling Pathways for Permitting Cross Talk between WNT and GnRHThe shaded pathway represents the skeletal features of the canonical Wnt/Beta-catenin signal transduction pathway APC GSK3B SRC JUN CDC42 PMC4918253__F1 Schematic view of the TLR4 signaling pathway.Notes: Upon binding of lipopolysaccharide (LPS) to the TLR4 complex (TLR4–LBP–CD14–MD2), TLR4 signals through MyD88-dependent and/or MyD88-independent pathways TBK1 CD14 TLR4 TRAF3 LBP TRAF6 IRF3 MYD88 IL1B TIRAP PMC8196612__F3 Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation GPR55 FAAH TRPV1 GPR119 PMC4835495__F2 Control of the FA pathway by SUMO and SUMO-like modifications REV1 FANCD2 SENP6 SLX4 RNF4 BRCA1 RNF168 ATRIP PIAS1 ERCC1 ATR PCNA USP1 PMC4383338__F9 Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation CD14 TLR4 IRF3 MYD88 PMC10836493__F3 Mechanism by which GPX3 is involved in maintaining the stemness of OCSCs in the TME GPX3 SCD CD44 TG PMC4113420__F4 PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-independent Mismatch Repair MSH6 PCNA PMS1 PMC11810530__F2 IHD‐mediated pyroptosis occurs through canonical, noncanonical and alternative pathways NLRP3 TLR4 TRAF3 TRAF2 FADD GSDMD DFNA5 PMC11810530__F1 Pyroptosis signalling cascade in IHD involves a series of events NLRP3 TLR4 TRAF3 GSDMD PMC12074965__F5 UDP-GlcNAc And CMP-Neu5Ac Synthesis In Mammary Epithelial Cells: In the cytoplasm, glucose (Glu) enters the cell via glucose transporter 1 (GLUT1) and is phosphorylated by hexokinase (HK) to form glucose-6-phosphate (Glu-6-P) GNE CMAS AQP3 NANS NANP PMC2778342__F2 Roles of the selected genes in the DSBR pathway BRIP1 BRCA1 XRCC5 CHEK2 ZNF350 ATM BRCA2 RAD50 RAD52 RAD51 H2AX XRCC3 RAD21 PMC3053440__F1 Toll-like receptor signaling pathway TLR4 HEL-S-71 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TIRAP TAB3 PMC3423541__F2 Biological targets under investigation for treatment of SLE CD40 SYK MTOR IRF4 ICOS PMC11998019__F3 Exploration of Traditional Chinese Medicine Comprehensive Treatment of Triple Negative Breast Cancer Based on Molecular Pathological Mechanism LBR LIF MTOR PMC6381741__F2 Differential expression of A ATF4 EIF2A UFD1L BAX PMC7933966__F6 Schematic underlying mediation mechanism of CRKL on glucose metabolism in hepatocarcinoma GSK3B CRKL PMC4651023__F4 Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation FOS RELA SMAD4 JUN PMC8053626__F6 The mechanism of abnormal cholesterol transport in the 827G cybrids ABCG8 ABCG5 NR1C1 HMGCR RXRA PMC7851442__F2 DCs in cancer therapies HMGB1 CGAS P2RX7 CXCL10 FLT3LG TLR3 CXCR3 NLRP3 TLR4 CXCL9 TREX1 CD40 FLT3 PMC8283010__F3 Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation MMP3 PLG TNF TRAF2 IL1B CEBPB PMC7183768__F8 CREB signaling in neurons in response to granisetron treatment with the IPA molecule activity predictor TBP GRB2 PMC5328851__F2 Schematic diagram demonstrating the mechanism of action of perlecan and endorepellin in angiogenesis and autophagy VEGFA MTOR PEG3 PMC3695728__F2 Exploring mechanisms of FGF signalling through the lens of structural biology PLCG1 MARCKS BAD FOS GRB2 BAX PMC7010080__F2 NAD+ in cancer metabolic reprogramming SIRT2 SIRT6 HEL-75 IL2 SIRT1 HEL-S-162eP SIRT3 PMC12074965__F2 Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing AQP3 HEL-S-19 GAL PMC7010080__F1 Compartmentalized NAD+ metabolome in humans SIRT2 PARP1 NMNAT3 NRK SIRT3 NAPRT SIRT7 NMNAT1 SIRT4 SIRT5 SIRT6 NMNAT2 SIRT1 PMC7781229__F1 Mechanism and function of therapy-induced senescence PML SUV39H1 ATM CDK4 ATR CDK6 PMC10244546__F1 Potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma MTOR CD81 STAT3 BAX PMC9112071__F6 Chromosome-Level Genome of the Camphor Tree and the Underlying Genetic and Climatic Factors for Its Top-Geoherbalism MVD MVK IPP PMC11946974__F1 Bitter Taste Signaling Pathway CALHM3 CALHM1 TRPM5 PMC11200880__F1 Oxytocin signaling brain pathway TLR4 KCNJ13 SLC12A5 OXTR MAPK7 EGFR EIF2A MARK1 RGS2 OXT RAF1 TRPV1 PMC12095162__F3 NOD2 receptor signaling pathway RIPK2 MAP3K7IP1 NOD2 TAB3 PMC8442909__F4 Characterization of the Potential Role of NTPCR in Epithelial Ovarian Cancer by Integrating Transcriptomic and Metabolomic Analysis GBP1 OAS2 IRF7 TNF MX2 PMC9049047__F1 All roads lead to DSBs BRCA2 RAD51 BRCA1 PMC6669812__F2 Leptin binds to the LEPR and mediates multiple downstream pathways MMP7 GRB2 LEPR EIF4E CAD MTOR STAT3 PMC7775514__F1 Toll-like receptor 4 (TLR4) signaling in Alzheimer disease (AD) TBK1 CD14 HMGB1 TLR4 TRAF6 IRF3 PLCG2 MYD88 APOE TIRAP CDC42 CD36 PMC7916307__F2 IAP-p53 axis is an essential regulator of a multitude of cellular pathways COX2 NAIP XAF1 BIRC5 EGFR KLF5 MDM2 DROSHA PIAS1 HDAC2 TF STAT3 PMC8998929__F3 Hippo Signaling in the Endometrium STK4 ARHA TAGLN PMC8998929__F1 Hippo Signaling in the Endometrium STK4 PTEN MTOR FRMD6 PMC5360391__F6 Proposed hypothesis for the effect of melittin on formation of osteoclast-like MNCs NFATC1 TRAF6 IL1B PMC5665463__F6 Model for HCN4 function in establishing laterality NODAL PITX2 HCN4 PMC3733232__F1 TGFBeta-mediated signaling and transcriptional regulation in pancreatic development and cancer EGF IL1B IFNG PMC6943435__F1 Metabolic remodelling in lung cancer PC ALK GCLC EGFR ACLY HEL-S-133P HK2 PMC9049047__F5 All roads lead to Gaps GAPT BRCA2 RAD51 BRCA1 PMC3381938__F5 Alternative Macrophage Activation and Metabolism ARG1 PMC3778921__F4 Integrative Analysis Reveals an Outcome-associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B-cell Lymphoma BCL2L12 DKFZp781B1423 TFDP2 RB1 CDKN2A CCND3 TFDP1 CDK6 PERP CDK2 MDM2 BCL2 CDK4 RPL26 CDC2 KDM6B RBL2 BAX PMC2771153__F9 Schematic presentation of a model of induction of beta cell apoptosis during viral infections RNASEL OAS1 INS TLR3 PMC10966608__F4 EcDNA in drug resistance BRAF EGFR DHFR PMC6858087__F1 Structural variability in the RLR-MAVS pathway and sensitive detection of viral RNAs TRAF5 TRAF6 IRF3 TRAF2 MAVS PMC5522741__F1 Aging is a complicated process, often characterized by increased ROS and inflammation FOXO3A SIRT1 FOXO1 PMC4076843__F2 Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders AHR CYP1A1 PMC3151428__F3 Suppression of anaerobic metabolism by p53 is mediated through multiple pathways TIGAR PTEN HK2 PMC12131575__F6 Schematic diagram showing the possible mechanism of noise-induced cognitive decline FOXO3A SGK1 BCL6 PMC9288732__F2 Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes VPS35 PINK1 FLCN LRRK2 PLA2G6 VPS13C ATP6AP2 MTOR PMC5912981__F1 GCN5L1/BLOS1 links acetylation, organelle remodeling and metabolism TFEB FBXO15 PMC8236063__F8 Mechanistic scheme of DNA-methylation-mediated RSPO2 regulating GCs proliferation, apoptosis and E2 secretion GC CCND1 PMC5835171__F1 INNATE IMMUNE CONTROL OF ALPHAVIRUS INFECTION RNASEL ISG15 OAS3 PARP12 IFITM3 PARP10 IFIT1 PMC4382242__F2 Autophagy in cellular metabolism and cancer ULK1 DKFZp686F0183 PMC9106601__F1 WNT and NOTCH signaling in human trophoblast development and differentiation APC NOTUM PMC2766863__F2 Signalling crosstalk in B cells: managing worth and need BCL10 BCR BASH LYN TRAF3 GRB2 RELB SYK PLCG2 REL TRAF2 CD19 PMC7411000__F1 Illustration of BPA on LC development SCARB1 NR3A2 CYP11A1 HSD17B3 STAR PMC3525024__F7 Schematic representation of canonical and noncanonical Hh signaling activation in MM PTCH1 SHH CCND1 SMO PMC8578498__F4 VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases VGF SYN1 MTOR BDNF PMC8701796__F6 Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia–Reperfusion GNG5 GNB3 PIG59 TRPC1 SHANK1 GRM3 HOMER1 GNAI3 SHANK2 GNB1 GNB4 PMC3628696__F5 Ingenuity Pathway Analysis (IPA) was performed with proteins where SUMO3 conjugation was 2- or more fold up-regulated in any gel slice PML SUMO3 RUNX1 NAB2 NXF2B CHD3 CBX4 PIAS2 TCERG1 HNRNPUL1 ATN1 SOX10 HNRNPF SOX6 NCOR2 TARDBP SUMO1 PMC10743592__F2 Presentation of the action of ghrelin on autophagy ULK1 ULK2 MTOR PMC10743592__F3 Presentation of association between apoptosis and necroptosis RIPK1 TRADD RIPK3 BCL2 FADD MLKL BAX PMC7395694__F9 Model for miR-214 regulation upon CC cell progression PTK6 STAT3 PMC5980154__F6 Schematic diagram illustrating how ɑ‐LA, via regulation of Grb2 expression, modulates different signalling pathways that participate in proliferation‐related stress responses EGF HGF GRB2 SRC MTOR TF PMC7260346__F5 De novo transcriptome analysis unravels tissue-specific expression of candidate genes involved in major secondary metabolite biosynthetic pathways of Plumbago zeylanica: implication for pharmacological potential INA COG3 PMC8741861__F10 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells HEL-S-11 FSHR APPL1 PMC4666507__F1 Described mechanisms involved in steroid hormone regulation of cancer stem cell populations NOTCH2 TBX3 EGFR KLF4 GATA3 FGF9 BCL6 PMC11640042__F1 Wnt signaling pathway NLK APC LRP5 LRP6 RYK PMC8222790__F4 Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML TH IMPACT STAR PMC11640042__F3 Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities APC LRP5 LRP6 SFRP1 GATA5 TM4SF1 PMC11640042__F2 Wnt signaling regulates HCC biological behavior RUNX3 TRIM16 CDK6 NLK LIMA1 BEX1 TRIM54 SOX11 SOX15 MBD2 ABCB1 FZD10 TCF4 EPHB2 PMC1781473__F3 Exploitation of Eukaryotic Ubiquitin Signaling Pathways by Effectors Translocated by Bacterial Type III and Type IV Secretion Systems NEDD8 MAP3K7IP1 TAB3 PMC8046533__F3 KEGG Pathway analysis of IFNg protein in tuberculosis disease CD14 INA MADD MYC CASP9 IL4 PMC7527722__F7 Klebsiella pneumoniae ablates SUMOylation via distinct pathways in epithelial cells or macrophages TLR4 EGFR GSK3B NEDD8 SENP2 PMC5753009__F3 ATX-LPA axis promotes cancer-related inflammation IL16 ATF2 MMP9 SRC ARHA LPA HIF1A MTOR JUN TERT STAT3 PMC7246870__F5 Ingenuity Pathway Analysis (IPA) of five genes (CXCL10, FOS, UBE2N, IL1A, and TLR4) that are commonly regulated by both regorafenib and lenvatinib showed a close association with cell proliferation signaling pathways (red color) IL1A TLR4 FOS HEL-S-71 PMC5938431__F3 Interferon regulatory factor 1 inactivation in human cancer ISG15 CDK2 BRIP1 IRF3 TYK2 PMC4008226__F8 A mechanism for integrated regulation of motility and adhesion in T cells and its role for transendothelial migration CD47 CXCR4 CXCL12 PMC4342183__F6 MAPK signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate MAPK signaling pathways CD14 EGF NGF FLNA EGFR TNF MAP3K7IP1 NLK PAK1 MAX JUND BDNF TRAF2 MEF2C PMC3980725__F1 PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer EGFR PTEN INPP4B IRS1 PMC7063406__F2 Epithelial and Epidermal barrier dysfunction: Various molecules involved in the signaling pathways shown in figure are maintaining the epithelial and epidermal barrier IL16 GUCY2C EGFR CCND1 TTC7A IL6 MYD88 TNF PMC4342183__F8 VEGF signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the VEGF signaling pathway COX2 BAD CASP9 SRC CDC42 PMC3744771__F1 Inhibitory molecules and therapeutic targets within the Rhopathway HEL-S-62p RGMA ARHA LINGO1 EPHA4 PMC4342183__F7 Notch signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the function of the Notch signaling pathway HES5 NUMB HES1 PMC5382886__F1 TLR4, MyD88 and TRAF6 down-regulation following glutamine administration in LPS-stimulated peripheral blood leukocytes of pancreatic cancer patients CD14 TRAF6 MYD88 TIRAP PMC3621284__F2 Proposed role of aPKCs in synaptic plasticity: At most CNS synapses, strong synaptic input leads to an activation of PI3K signaling and PDK1 activation thereby (1) thereby leading to mTORC1 activation ELF3 EIF4E PSD PMC3077378__F7 Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling EGFR FLT3 PMC4342183__F2 Wnt signaling pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-181a-5p is a regulator of Wnt BAMBI ROCK2 NLK DAAM1 SIAH1 APC SOST CER1 SMAD4 SKP1 ARHA RBX1 PMC4342183__F4 p53 pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate the p53 signaling pathway MYC PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 PERP ATM MDM2 CASP9 C6 ATR CASP8 PAF1 BAX PMC4342183__F3 Cell cycle pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate a number of important proteins that control the cell cycle E2F4 PLK1 SMAD2 APC GSK3B SMAD4 STAG1 DBF4 ORC3 CDK7 STAG2 CDK6 ORC2 CDC20 SMC3 CDK2 MDM2 CDK4 CDC2 PCNA SKP2 MYT1 PMC7057932__F2 Cellular signaling pathways associated with the mutated genes of the biliary tract cancer (BTC) cases BRAF EGFR MYC PTEN RB1 MTOR HRAS CDKN2A CHEK1 CDK6 CHEK2 NF1 PI3 ERBB4 CDKN2B ATM ERBB2 MDM2 CCND1 CDK4 ATR ARAF PIK3R2 PMC8777554__F2 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance BAMBI RNF43 APC GSK3B PMC8777554__F1 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance ROCK2 DAAM1 INVS ARHA PMC8358957__F2 Endocannabinoid system – current implications for drug development NAAA ABHD6 DAGLB DAGLA FAAH PMC4741978__F3 SNP-SNP interaction analysis of NFKB signaling pathway on breast cancer survival NFKB2 NFKB1 TRAF3 TRAF2 PMC7068866__F6 Metastasis prediction: optimum centered Bayesian network found PML PRDM11 NAV1 opn CDCA4 FRAS1 P4HA2 MASP1 SHANK1 ZNF550 KLF14 RIOK3 COLEC10 DNAAF3 ITPRIPL2 RAB7A ZNF428 ZDHHC1 SH3PXD2B ZNF75D KCNS2 EED SMAD9 VSX1 ZNF597 JMJD6 ERAP1 RBMS3 CXCL9 HECW1 YY1 HEL107 PMC6201246__F6 Overview of current understanding of the pathogenesis of HIT HEL-S-62p PF4 VWF ELL PMC6273515__F3 Bound sulfur activates the nuclear factor erythroid related factor 2 (Nrf2) system through a structural change of Kelch-like ECH-associated protein 1 (Keap1) and promotion of the AKT/phosphoinositide 3-kinase (PI3K) signaling pathway DAO PMC8638743__F2 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses DKFZp781B1423 MDM2 PTEN MTOR PMC8638743__F1 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses TSC2 RICTOR TSC1 PTEN MTOR DEPTOR RHEB PMC5942188__F1 Review of craniofacial and dental findings of the RASopathies RIT1 NF1 CS BRAF SOS1 PMC10501637__F5 PPI network analysis of total DEGs in ELMOD3mut and ELMOD3corrected iPSCs RLN2 EPHA3 EFNA1 CX3CL1 APLN GRPR KCNMA1 EPHA8 EFNA3 SHC3 CNR1 GALR1 MYL7 PCSK9 POMC FAM20A ATP1A4 opn CXCL6 KNG1 ADM ANXA1 CALCA SCT CXCL2 GABRB2 AVPR2 CLDN4 IGFBP5 CCKBR RS1 NMU EDN1 CCK GNA15 EDNRB CHRM3 ATP2B2 HEL113 BDKRB2 GABRA3 NEFL XCL2 PMC3342043__F1 TLR2 signaling STAT1 IRF7 IRAK1 IRAK2 TRAF6 IRF3 IRAK4 MYD88 TLR1 IRF2 IRF-1 TIRAP PMC6689183__F8 Dropwort extract exerts broad anticancer effects on MPM cells affecting cell proliferation, viability, migration, metabolism and in vivo tumor growth of MPM cell lines ANKRD1 TEAD3 NUAK1 TEAD4 MCM7 MTOR TEAD2 PMC2723150__F1 Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals ND1 INS RAN OTP NANP CALY NNAT MAL PMC3159004__F2 TLR-independent innate immune responses NFATC1 IRF3 PMC5370040__F1 Tumour-derived exosomes as a signature of pancreatic cancer - liquid biopsies as indicators of tumour progression CD9 CD151 CD63 CD81 PMC6172067__F5 Prognostic biomarkers in clear cell renal carcinoma ITK TNFSF6 SPI1 VEGFA HEL113 NTRK2 CD36 PMC5983591__F1 Growth hormone releasing peptide (GHRP)-peroxisome proliferator-activated receptor-gamma (PPARG) pathway in lipid and energy metabolism INSIG1 ABCG1 ABCA1 APOE CD36 PMC4118128__F9 The proposed model for the regulation of the IRS-1-PI3K-mTOR pathway by PRCP and PREP MTOR IRS1 PMC7820188__F2 Wnt signaling, structure and activation: Wnt signaling is activated when glycoprotein ligands of the Wnt family bind Frizzled transmembrane receptors located at cell membrane level APC RHO CDC42 PMC9404549__F9 Salvia chinensis Benth Inhibits Triple-Negative Breast Cancer Progression by Inducing the DNA Damage Pathway FANCD2 ATM RAD51 ATR H2AX PMC2642591__F1 Retinoic acid dependent regulation of immune responses by dendritic cells and macrophages APC HEL-S-53e ADH5 HEL-S-4 FOXP3 PMC2254474__F1 P2Y receptor-mediated signalling cascades in C6 cells GFAP GRB2 ARHA JUN PMC6687752__F7 CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3 SAP18 CXCL1 IL8RB HRAS STAT3 PMC4800795__F10 FAF1 action on the innate-immunity signaling pathway TBK1 ISG15 IRF3 IPO5 MAVS FAF1 MX1 IFIT1 PMC4762492__F1 PI3K/AKT/mTOR signaling pathway and examples of drugs targeting each of its components.Note: RSK, 90 kDa ribosomal protein S6 kinase BAD EGFR PTEN INPP4B RPS6 RHEB PMC2818872__F8 Ras signaling in early B cell development SOCS2 SOCS3 CXCR4 PMC11659631__F8 Mechanism of GGO inhibited cervical cancer cell proliferation and angiogenesis MMP2 MMP9 PTEN MTOR SPRY2 PMC10296830__F1 The Hippo pathway and YAP/TAZ mechanosignaling MAPK6 MAPK7 ARHA LATS1 ARHGAP29 LATS2 PMC3875462__F1 Regulation of the mTOR signaling pathway TSC2 TSC1 PTEN EIF4E STRADA RHEB PMC3659299__F4 Scheme depicting the current knowledge on PAC1-mediated signaling cascades resulting in a variety of neuronal outcomes NGF HEL164 UNK SRC PMC4013678__F2 Bayesian Brain Immune and Microglia Module CTSS CD33 IL13RA1 LAT2 ARHGAP30 TGFBR1 GPX1 APOC1 MFNG PTGS1 CD74 HLA-DMA CCR1 CMTM7 CMTM6 RBM47 SERPINA1 ADAM28 PTPN6 ARPC1B MYO1G PBR PARVG WDFY4 RUNX1 FPR1 GRN TNLG7A TCIRG1 HLA-DOA IL10RB TYROBP PTPRC CSTA TNFRSF1B LYN LILRA2 SYK HLA-DRB4 REL DOCK2 HLA-DMB PYCARD SLC15A3 HEL-S-43 PMC5652852__F1 Chromosomal instability and acquired drug resistance in multiple myeloma CDC20 APC ERCC1 ERCC2 CCNE1 PMC4461483__F4 Possible role of Naa10 in cellular hypoxia ARD1A ACLY PMC10943832__F2 Metabolic pathway of tryptophan (Trp) HAAO KYNU AFMID CYP2E1 PMC10943832__F5 AhR signaling pathway IL10 NLRP3 CUL4B AHRR AHR SRC RBX1 DDB1 TBL3 KLF6 TF PMC3469769__F2 Multiple roles of COUP-TFII in cancer initiation and progression APOA4 LIPC NR5A2 NPPA PCK1 APOC3 NR1C1 NR2F2 RARB KDR SHBG NRP1 RBP2 NR1H4 ALDH2 PMC5641361__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection CPA3 MAS1 PIKFYVE CTSA MTOR ACE2 MME PMC8220449__F7 Schematic diagram depicting the effect of TMJ-12 on the PI3K/AKT signaling pathway leading to the induction of apoptosis and cell cycle arrest in BPH-1 cells BAD PTEN EIF4E MTOR BAX PMC7330089__F8 Regulatory model of the MBW complexes for juvenile red fading in sweetpotato leaves HEL-S-62p MYB PMC5404519__F1 Biosynthetic pathway of the major phospholipids in bacteria PGP C1S PSD PMC5992185__F4 Molecular structure, posttranslational modifications, and protein–protein interactions of the Ski and SnoN proteins PML HIPK2 HDAC3 SMAD2 SMAD4 TEAD4 SIX1 LATS1 HDAC1 AURKA LATS2 GATA1 TEAD2 NF1 TEAD3 SMURF2 GLI3 FHL2 PIAS1 SKI EYA3 JUN SIRT1 RB1CC1 PMC4467754__F14 Scheme of possible mechanisms by which AT-101 enhances the anticancer activity of CDDP in NSCLC MYB EGR1 PAX5 HLF PAX8 STAT3 PMC5641207__F1 Single-cell genomic analysis of head and neck squamous cell carcinoma EGR1 RELA MYC VEGFA SMAD4 SP1 PMC11810091__F7 Changes in mucosa branched N-glycosylation impacts gut microbial balance, leading to an intestinal inflammatory response MGAT5 hCG_1998026 NOD2 PMC3291999__F3 MTOR signalling pathway (see text for details) TSC2 TSC1 PTEN EIF4E IRS1 RHEB PMC5992185__F5 Ski and SnoN protein stability by the TGFB/Smad signaling pathway SMAD2 APC SMURF2 SKI PMC8399070__F1 Nanocarriers as a Tool for the Treatment of Colorectal Cancer FADD BAX PMC5342415__F3 Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer PIK3R1 F10 PLA2G2E RB1 TFDP1 GPX7 ACOX1 HEL-S-78p TBP GSTT2 PRKAR1B COL2A1 FGA SNCA PLG WASF1 TAF10 VAV1 GTF2H4 LAMB3 TSC2 GGT7 BRCA2 TP73 F7 SGPL1 TNR ATR GP1BB SGMS2 TAF4B DEGS2 F2R BLM CDKN2D CCND2 CHEK2 CCNB1 APP CERK SMS CD47 AKAP8 RPA1 NFATC1 MGST3 KLKB1 GTF2F1 GSTM2 PTPRC RRM2B MGST1 SLC23A2 SMPD1 GTF2F2 PLA2G2F CR2 NCF2 PMC5706051__F7 Diagram depicting epinecidin-1-mediated degradation of MyD88a and downstream events TLR4 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 PMC3908416__F8 Panx3 signaling pathways inhibit osteoprogenitor cell proliferation and promote cell cycle exit GSK3B LRP5 LRP6 PANX3 PMC3616489__F3 Emerging roles of E2Fs in cancer: an exit from cell cycle control E2F4 E2F5 CDK4 CDK6 PMC3596655__F8 Proposed molecular mechanisms of the anti-inflammatory effects of allosteric SHIP1 activation BTK PI3 PTEN PMC8150642__F1 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism FOS MYC HIF1A MTOR JUN PMC5992185__F2 Regulation of Ski and SnoN expression by different mechanisms HGF NODAL SMAD2 SMAD4 BMP7 SKI PMC8150642__F2 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism HEL-S-26 GOT2 ASCC2 ACLY HEL-S-133P ACSL3 HEL-S-32 HEL-S-5 GLS PMC5992185__F1 Regulation of the TGFB/Smad signaling pathway by Ski and SnoN SKIL SMAD2 SMAD4 SKI PMC6079274__F2 JAK2 protein in intracellular crosstalk GRB2 MTOR IRS1 PMC8772740__F6 Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation NRP1 ARHA RAC1 PMC4898659__F3 Signalling pathways modulated by NF1 NF1 TSC2 TSC1 MTOR RHEB PMC10215719__F7 Proposed mechanisms of the effect of Ptn overexpression (A) and the pharmacological inhibition of RPTPB/ζ with MY10 (B) on some of the principal signaling pathways implicated in ethanol and/or LPS acute response in adolescent mice FYN TLR4 PTN ALK PMC5545101__F3 mTORC1 signaling and the metabolic control of cell growth OMP ATF4 MYC CAD PMC8533248__F2 Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs IL13RA1 COL3A1 SMAD2 LRP5 KLF4 SMAD4 LRP6 JAK1 MTOR COL1A1 MAP3K7IP1 PMC2562939__F1 The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin DPH2 DPH5 DPH3 DPH1 PMC3656947__F3 PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells dik ADAMTS9 PPP3CC RELB ARID2 NFKBIZ G0S2 SCIN B3GNT5 STK10 PLK3 EHD1 VGLL4 MFHAS1 SERPINB8 IL6 TNF HAS2 RNF19B ABTB2 CLIP2 ALDH1A3 RELA TNFAIP2 SLC2A6 TNFRSF10A REL PMC5972910__F11 Putative role of Wnt signaling pathway during BoHV-1 latency-reactivation cycle WIF1 AKT3 PMC11107893__F1 Molecular targets and therapeutic interventions in non-small cell lung cancer treatment RET BRAF EML4 ALK EGFR CDK4 MTOR ROS1 CDK6 PMC7735419__F4 Image of the potential transcription factors of GPX8 CRX TCF3 IRF7 ATF1 GPX8 SOX18 SOX17 SRY FOXC1 ZNF407 SCRT1 SPIB SCRT2 ZNF732 SATB1 SOX12 CDX1 IRF4 HIC1 TCF4 PMC9006080__F5 Molecular Signatures of Mitochondrial Complexes Involved in Alzheimer's Disease via Oxidative Phosphorylation and Retrograde Endocannabinoid Signaling Pathways TUBA4A PPP3CA BACE2 ATP6V1C1 ATP6V1C2 UQCRFS1 HEL-S-66p TUBB2A ATP6V1E1 FZD9 SDHA SDHB SNCA TUBB RTN3 ADCY1 RTN4 PSMB2 CDK5 NDUFAB1 CALML4 PPP3R1 CHRM3 TNFRSF1A ATP6V0E1 RYR3 GPR83 PSMD6 PSMD1 PMC8435904__F5 LncRNA GAS5 Competitively Combined With miR-21 Regulates PTEN and Influences EMT of Peritoneal Mesothelial Cells via Wnt/Beta-Catenin Signaling Pathway PTEN PMC9016245__F3 Mitochondria signaling pathways in allergic asthma PRMT1 SMAD2 PMC7735419__F8 Proposed molecular mechanisms of GPX8 in gastric cancer cells FOXC1 APC GSK3B GPX8 PMC6644836__F4 Partial diagram of the “Signaling by SCF-KIT” pathway showing the feedback loop that generates the “p-STAT dimers” complex annotated in Reactome KIT VAV1 GRB2 PTPN11 PMC12240780__F5 LLPS in mutant tumor suppressor genes driving carcinogenesis NF2 APC SPOP PMC12240780__F4 LLPS in tumorigenesis due to FOs SS18 GRB2 HDAC2 SOS1 HDAC1 PMC12240780__F3 LLPS regulates cellular phenotypes ULK1 ATG101 PMC4633218__F7 Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet ADIPOR2 SIRT1 PMC7910492__F8 Mechanism for the synergistic effects of BKM120 and olaparib on the death of MDA-MB-231 cells BRCA2 SSB PARP2 RAD52 RAD51 PARP1 BRCA1 FOXO1 PMC11921546__F2 LPS-TLR4 mediated signal transduction pathway TBK1 CD14 TANK IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TRPM7 SIL1 TLR4 LBP SYK PMC5256158__F5 Schematics of multitargeted actions of T1AM on metabolic and steroidogenic pathways ADFP SREBF2 CIT TG PPARG GPAM STAR MAL PMC6053305__F10 PERK signaling pathway in modulating skeletal phenotype FGF21 ATF4 SOX9 PMC139401__F2 TLR signal transduction pathways STAT1 TLR4 TRAF6 MYD88 IL1B TIRAP MAL PMC6407245__F1 Nongenomic and Genomic actions of Thyroid hormone and thyroid hormone receptor NCOR1 SRC ME3 MTOR NR1A2 THRA STAT3 PMC8449055__F2 New strategies for targeting kinase networks in cancer DDR1 BRAF EGFR AXL PMC2820927__F3 Model illustrating the dynamic overlapping phases of early events of KSHV infection in endothelial and fibroblast cells and KSHV-induced signal pathways and their role in infection SRC RHO PMC3215943__F4 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY EGR1 ARC MTOR NPAS4 PMC2875805__F10 Cartoon illustrates genomic and nongenomic actions of VDR signaling in inhibition of human CYP7A1 gene transcription in human hepatocytes NCOR1 NR1i1 SRC RXRA PMC3215943__F3 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY EGR1 ARC MTOR BDNF PMC6537015__F8 The proposed mechanism underlying TRPA1-mediated CMF transdifferentiation and cardiac fibrosis after MI injury ACTA2 POSTN TRPA1 TGFBI PMC5045229__F4 Cabozantinib provides dual inhibition of MET and VEGFR2 preventing the MET pathway from acting as an alternative pathway in the development of VEGF TKI resistance BAD HGF MDM2 MTOR PMC2219551__F7 Signaling Pathway Involved in Neutrophil Elastase–Stimulated MUC1 Transcription MUC5AC DUOX1 EGFR SP1 TGFA PMC8413298__F9 Many gCIS function on the same pathway as the oncogenic driver responsible for tumor initiation PIK3R1 HGF SOCS3 EXT2 UBR5 CD44 LATS1 SH2B2 RHEB CREBBP KDR RYBP GAB2 MDM2 GRB2 PPP2CA LPP SH2B1 TRIM24 SOCS5 SP3 PMC5795421__F2 Human micro RNA (miRNA) pathway DGCR8 DROSHA PMC2713330__F1 Innate Immunity in the Lungs TBK1 CD14 TLR5 TLR9 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 IL1B TIRAP PMC8097099__F1 SUMOylation Wrestles With the Occurrence and Development of Breast Cancer SUMO3 SUMO2 SAE1 RANBP2 SUMO1 PMC4338202__F5 Whole Transcriptome Analysis Using Next-Generation Sequencing of Sterile-Cultured Eisenia andrei for Immune System Research IRAK1 MYD88 TIRAP PMC4499885__F5 Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells EGF EGFR TGFBR1 JAK1 STAT3 PMC7012612__F4 IGF1 signaling pathway is under increased evolutionary constraint in long-lived, large-bodied mammals PRKCZ IGF1R BAD HEL2 NCK2 RHO CRKL PDPK1 PI3 PTPN1 PTPN11 SRC RAC1 HRAS CRK IRS1 PRKD1 IGF1 GRB2 RAF1 GRB10 SOS1 HEL-S-93 SHC1 PXN PMC4083591__F1 Type I Interferon in the Pathogenesis of Lupus CGAS PDC IRF7 IRAK1 STAT4 TREX1 TYK2 TNFAIP3 DKFZp686F0183 PMC7142266__F3 Functional domains of BRCA1/2 protein with pathogenic mutations SCD ATM BRCA2 BRIP1 BARD1 BRCA1 RAD51C PMC7142266__F2 Mechanisms of tumorigenesis attributable to FA mutations FANCD2 FANCL FANCA ATR CHEK1 BRCA1 FANCE FANCF PMC8171373__F1 Hijacking the Pathway: Perspectives in the Treatment of Mature T-cell Leukemias ITK HEL-S-171mP ATM MDM2 BCL2 MCL1 BAX PMC5589605__F4 Systematic analysis of coronary artery disease datasets revealed the potential biomarker and treatment target LEP TCF3 FOLR3 CEBPA ARG1 PADI4 ASL PMC6467965__F2 Schematic presentation of the cytotoxic pathways, induced in cancer cells by the complement C5b-9, the counteractive cellular resistance mechanisms, and postulated approaches to overcome this cancer evasion HEL-S-62p CD59 CD46 RIPK3 CD55 MLKL PMC8107084__F6 MiR‐155 promotes colitis‐associated intestinal fibrosis by targeting HBP1/Wnt/B‐catenin signalling pathway APC PMC5882217__F3 Hippo pathway and cross-talk with other signaling pathways in mammals NLK AMOT NF2 AREG OGT APC VGLL4 LATS1 RHO LATS2 PMC5133786__F1 Proteolytic processing of the amyloid precursor protein (APP) and its modulation by vitamins A, D, E, and K VIT ADAM9 APP PMC3829599__F1 mTOR pathway signaling cascade TSC2 TSC1 GRB10 ELF4 IRS1 RHEB PMC6997601__F2 MVA pathway and the synthesis of astaxanthin and ergosterol in X MVD MVK IPP PMC6743006__F3 Exposure to high fat diets over time, enriched in saturated fatty acids, would promote the glial activation and an increased mitochondrial oxidative stress APP IRS1 NR1C1 PMC3277712__F1 Importance of cytokine signalling for CD4+ T-cell differentiation IL6 GATA3 FOXP3 PMC3899195__F6 ZNF365 promotes stalled replication forks recovery to maintain genome stability CDC20 APC PMC8844036__F8 Schematic diagram of sEVs DNAJB8 based signaling pathway in CRC L-OHP resistance PGP PMC7842149__F3 Angiotensin II and T lymphocytes activation during COVID-19 best scenario TH ADAM17 TMPRSS2 PMC9562224__F11 HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1A/HEY1 Signaling Pathway KDR VWF PMC11951404__F1 Transcriptional and posttranslational regulation of CONSTANS (CO) CO acts as the core regulator of the photoperiod response pathway to integrate external and internal signals into the photoperiodic flowering pathway CRY2 RFWD2 PMC7842149__F1 Roles of the RAAS in health and COVID-19: A better and worse scenarios—(A) Basal angiotensin system ACE2 GRAP ADAM17 TMPRSS2 PMC4384112__F3 IFN-induced signaling through the JAK-STAT pathway IRF9 PIAS1 TYK2 IFNAR2 JAK1 IFNAR1 PMC9773994__F3 Edible plant extracellular vesicles: An emerging tool for bioactives delivery GSK3B PTEN BAX PMC10215861__F3 Roles of RONSs during skeletal muscle pathologies ULK1 IGF1 MTOR IRS1 DMD PMC10975450__F2 Signaling pathway molecular mechanisms: Several signaling pathways play a major role in tissue development and thus in PSC differentiation, specifically into cardiac tissue DHH PTCH2 IHH FOXO3A NODAL SMAD2 IGF2 APC LRP5 SMAD4 LRP6 LATS1 MTOR IRS1 FOXO1 LATS2 PTCH1 F3 GLI3 SHH SMO SMAD1 SHC1 DKFZp781O1323 PMC6638919__F10 NADPH oxidase 4 mediates TGFB1/Smad signaling pathway induced acute kidney injury in hypoxia SMAD2 SMAD4 NOX4 PMC2702690__F9 Molecular Mechanisms of HIF-1A Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells BMP2 MTOR STAT3 PMC3690774__F5 Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17Beta-estradiol in embryonic zebrafish MAP1B ATOH1 PROC SMO IFT172 TRPV1 PMC5925819__F2 CDP-DAG and Kennedy pathways CDS1 CDS2 PSD PMC10341943__F3 Role of the Notch pathway in cell-fate decisions in the somite LBX1 PECAM1 PAX3 PMC7477297__F3 Hypothetical OT signaling pathways targeting the nucleus and mitochondria in the cardiac cells EEF2 GSK3B PGC MEF2C GATA4 STAT3 PMC8299209__F2 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway NLK FYN ARHA ROR2 STAT3 PMC8299209__F1 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway APC PMC5562273__F2 A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damage response and disease genes XPC ERCC1 XPA DDB1 TF PMC4172058__F1 Schematic diagram depicting the most representative signaling of the PI3K/AKT pathway TSC2 RICTOR BAD TSC1 GSK3B CCND1 PTEN MTOR PMC6269490__F1 Roles of CO in metabolic homeostasis FGF21 ATF4 EIF2A SESN2 PMC3177572__F6 Schematic diagram summarizing the bidirectional role of PIAS1 in regulating JNK-dependent oxidative stress responses SENP1 PIAS1 SUMO1 PMC8299209__F3 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway NLK TRAF3 TRAF6 IRF3 IRAK4 JUN IL1B TAB3 PMC9578543__F8 Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway BAD PMC4368378__F1 PINK1-Parkin signalling PINK1 USP15 RING1 PGAM5 USP30 PMC7222508__F6 Network of 145 candidate genes with main drug metabolism pathway genes ADAR MCC PTPRG SOS2 APC PTPRO DROSHA CTSA PICALM MTOR NCOR2 PMC10343931__F4 Possible mechanisms by which exercise upregulates NAD+ to improve mitochondrial autophagy SLC25A51 NMNAT2 POC1A SIRT1 PMC6913091__F3 Pushing the envelope: LPS modifications and their consequences TLR4 MYD88 PAG1 PMC5778108__F1 Canonical and non-canonical NFKB signaling in humans BCR RELA LTB RELB CD40 LTBR PMC8417591__F2 Extracellular Vesicles in Sickle Cell Disease: Plasma Concentration, Blood Cell Types Origin Distribution and Biological Properties NLRP3 TLR4 VCAM1 TF PMC4439968__F1 Toll-like receptor 4 signaling pathway HMGB1 TLR4 TRAF6 MYD88 PMC6684943__F1 Regulation of C/EBPB in MDSCs COX2 NOS2 ARG1 CEBPB PMC8540846__F1 Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer DUSP4 PALB2 BRCA2 F3 EGFR PTEN MTOR BRCA1 PMC3690116__F1 Schematic model of FGF-2 and FGF-18 signaling pathways in articular cartilage and IVD FGFR1 RUNX2 FGFR3 UNK COL10A1 PMC2841329__F1 Model for the role of ΔNp73B in the DDR ATM MDM2 RAD50 H2AX PMC4354324__F3 Multiple promising targets for regulating cancer metabolism ME1 ACLY FASN PMC2781055__F3 Ingenuity pathway analysis (IPA) of microarray data generated several genetic networks CCR2 MAP2 FCGR2A RAB27A HOMER1 HSF1 FST GHR KISS1 APP UNK PYY NPY1R PMCH ERBB3 CRK PRL EDNRB MAP2K1 CXCR4 TRH CCL20 NPFFR2 GH1 SH2B1 NPVF STAT3 PAX8 PMC11546116__F3 Vascular regeneration after MI DLL4 MSC NOTCH1 PMC11546116__F2 Regulatory mechanisms involved in myocardial regeneration TBX20 ERBB4 E2F4 ERBB2 CDK2 E2F2 MSC CDK4 NRG1 CDC2 PMC2732336__F1 Outline of the major cell surface receptor-mediated signaling pathways important in the differentiation, survival, and function of melanocytes BAD GSK3B PTEN CDH2 MTOR PMC4630409__F1 Schematic overview of TLR and NLR signaling pathways TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 NOD2 TLR3 PMC4659591__F10 MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma BAD IGF1R IGF1 CDK2 IGF2 MYC CDK4 CDC2 BNIP3 CDK6 BAX PMC10985960__F10 Hypothesis of possible IFN-I signaling pathway regulatory mechanism based on our findings in PD NFATC2 IRF9 TNF PMC9027317__F10 Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway TLR4 KEAP1 MYD88 NR1C1 PMC4379939__F1 As yet unknown side of DC secretion post-TLR activation, and trafficking molecules currently identified in DC function RAB11A VAMP3 STX4A SEC22B TRAF6 STX3A MYD88 VAMP8 SNAP23 MAL PMC3101238__F7 Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells OMP PC PUDP PMC9334696__F2 Biopolymeric nanoparticles based effective delivery of bioactive compounds toward the sustainable development of anticancerous therapeutics RHO BAX PMC6080592__F3 Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data EGF CYBA PIN1 VASP CTSS F2R THBD COL3A1 DAO EZR CD74 HEL-S-32 PRNP CXCL16 PLAT FYN A2M MMP2 INPP5D BIRC3 LPL HAGH HEL-S-281 BAX ITGA1 FABP2 LIMK2 CASP12 ITGB3 ITGA2B PDGFRA VAV1 OTC GNGT2 PDE1A CYBB TAPBP C1QB PRKCB PRODH PTPRE PRODH2 HSPA1A PMC9123807__F1 Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents ISG15 IRF-1 PMC9693393__F2 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve AMH ATM MTOR ATR PMC5384128__F1 Adaptive resistance and innate resistance ALK EGFR PTEN MTOR STAT3 PMC7257252__F5 Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells FGF21 EGF CCL5 STAT3 PMC4963952__F5 Regulation of genes of Cell Cycle pathway during senescence induction in HFF strains CCNA2 PLK1 TTK ORC6 DBF4 CHEK1 PKMYT1 CDC45 MAD2L2 CDC20 CDKN2B CDC6 BUB1B SMC3 CDK2 CCNB1 CDC2 PRKDC PCNA RBL1 MAL PMC5653149__F15 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer PTGS2 TXNIP SLCO3A1 NOS2 PSMB10 PPIC APOE PMC11604586__F1 Progress and perspectives on BMP9-ID1 activation of HIF-1A and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis HDAC7 VEGFA MTOR ID1 PMC9693393__F1 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve TSC2 KIT TSC1 LAT2 PTEN PMC4963952__F6 Regulation of genes of cell cycle pathway during senescence induction in MRC-5 strains CDCA5 GADD45G TTK ORC6 MYC PKMYT1 CDK7 ORC2 MCM3 CDC20 MCM6 MCM2 CDK2 E2F2 OPN4 PCNA MYT1 PMC7884039__F12 Molecular mechanism of p75NTR in regulating age‐associated changes in the homeostatic of synaptic plasticity ROCK2 LIMK1 ARC ARHA BDNF PMC5974538__F1 Occurrence of plant photodynamic stress FECH UROD UROS CPO PMC4075272__F2 Signaling pathways altered by MVNP and mutant p62 NR1i1 TRAF6 SIRT1 TAF12 PMC3091694__F6 Toll-like Receptor signalling canonical pathway CD14 LBP CSA2 TIRAP PMC5578405__F10 Schematic summary of the possible link between IGF-1R signaling, synaptic changes, neurotransmitter function and inflammatory response HMGB1 ChAT TLR4 IGF1R IGF1 HOMER1 MTOR PMC8555850__F1 Bile acid regulation CYP27A1 GCA CYP8B1 FGF19 CYP7B1 FGFR4 CYP7A1 HSD3B7 PMC6973012__F1 Molecular mechanisms in allergic inflammation MBP IL33 IL25 TNF TSLP ELL PMC6701793__F2 Biological processes associated with up-regulated genes after cecal ligation and puncture and back-regulated by landiolol infusion MAPK14 MARK1 CFDP1 HMOX1 CAPN10 MGST2 TP53INP1 FLOT1 VAPA A2M PDE10A NUP93 DBH ANP32B IMPDH2 CSNK1A1 CENPA MAPKAPK2 LCN2 NTF3 PTPRN EDNRB MAX TRH CREM ECSCR SLC35F6 FNDC3B PXK ENTPD1 CDA NOS1AP VASH1 NUDT4 APP NLE1 RPL10A CERK ARHGAP10 FGF2 BDH1 HEL-S-102 CD59 IPPK NFKB1 LBP AHSG SPTLC2 ST3GAL1 SHC1 STAT3 PMC9234285__F3 Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation CXCR3 CCR2 HLA-G PMC11671501__F3 Apoptotic caspase-mediated pyroptosis TNF BAX DFNA5 PMC8027873__F2 STRING diagram representing protein interaction pathway derived from the 77 proteins quantified in at least 80% of OCT and in none FFPE samples ZMPSTE24 TES NDUFB10 FHL2 DLD FERMT2 NPTN STK24 DLAT PMC7142266__F1 Schematic elucidation of the FA pathway mechanism used during DNA repair FAN1 PALB2 SLX4 ERCC1 ATR USP1 PMC3111844__F1 Overview of Androgen Metabolism Pathway Genes Considered, Including Candidate Genes and Genetic Variants Studied SRD5A2 CGN PMC6912814__F1 Summary of the main mentioned markers of the autophagy-lysosomal pathway (ALP) PINK1 LRRK2 PARK2 LAMP2 PMC8281110__F6 M6A in osteoporosis, arthritis and osteosarcoma (Review) YTHDF2 LEF1 DRG1 METTL3 ALKBH5 ATAD2 PMC4404310__F1 Proposed schema of aberrant signal transduction mediated by the TSLPR heterodimer in CRLF2-overexpressing ALL EIF4E MTOR TSLP PMC8281110__F3 M6A in osteoporosis, arthritis and osteosarcoma (Review) METTL3 MSC TRAF6 CEBPA MYD88 GDF11 MGA PMC5879898__F6 MAPK signaling pathway and the JAK-ATAT signaling pathway PIM1 EPO EGFR APP IL6 PMC9428757__F5 Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? NLRP3 TXNIP GSDMD PMC8762245__F2 Exosomes Regulate NLRP3 Inflammasome in Diseases NLRP3 ABHD5 MSC PMC7250321__F9 EV71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS accumulation MAF BACH1 ACOX1 PMC6983994__F4 This study showed that after 24 hours of treatment with YM155, the miR-9 expression levels increased significantly compared to control cells; in addition, the expression of two target genes, including MDR1 and SIRT1, decreased significantly ZEB2 BCL2 SIRT1 PMC2788021__F3 A model for torpor induction in mammals that links reduced availability of food in the environment with the energy status of the cell, the mammalian circadian clock, and response to oxidative stress NAMPT SIRT1 PMC3982918__F1 Notch signaling pathway and agents in clinical development DLL4 JAG2 MYC FURIN DLL3 CCND3 PMC8891342__F1 Impact of intracellular innate immune receptors on immunometabolism ALDOB HK3 CPT2 HEL-S-87p HK2 HEL-S-162eP PMC5366816__F2 Drug targets in AR signaling pathway EGFR MTOR CYP17A1 PMC7078111__F1 HGF/c-Met signaling and lncRNA/miRNA/c-Met interaction HGF GRB2 MTOR PMC6881418__F3 Roles of CAFs in drug resistance SERP2 HGF PDGFC CXCL12 PMC8455403__F7 Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance HOXA11 NRF1 PGR IGFBP1 opn HBEGF PMC9166529__F2 Characteristics of the cancer stem cell niche and therapeutic strategies SOX2 MTOR PMC8849249__F2 Low Bone Mineral Density in Hemophiliacs LRP5 LRP6 PMC7705238__F1 IL-23/IL-17 signaling transduction TRAF3 IL23R TRAF2 IL17RC TRAF4 STAT3 PMC4888770__F1 Radiation induced activation of canonical and non-canonical hedgehog (Hh) signaling pathway HHIP SUFU SMO PMC9166529__F4 Characteristics of the cancer stem cell niche and therapeutic strategies SUFU APC GSK3B SMO DKK1 PMC4503712__F3 Candida albicans proteins for metabolic pathway ADH5 HEL60 HEL-S-32 MDH2 PMC7705238__F2 T-cell immune axis and associated cytokines in the pathogenesis of psoriasis, hidradenitis suppurativa, atopic dermatitis, and alopecia areata NLRP3 CCR6 S100A8 CCL20 FLG S100A9 S100A7 PMC8208619__F6 CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition SI CXCR4 MTOR PMC9254464__F7 Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest HEL-S-2a RAB7A MTOR PMC3379883__F2 Leptin and the CNS Control of Glucose Metabolism SOCS3 STAT3 PMC8998760__F1 Interplay between PARP Inhibitors and Immunotherapy in Ovarian Cancer: The Rationale behind a New Combination Therapy CGAS GSK3B IRF3 PMC3045854__F1 Memory genes identified in model systems overlap with genes identified in human mental retardation NF1 TSC2 EGF TSC1 GRB2 RHO MTOR TGFA OPHN1 PMC7564838__F1 The metabolic pathway for MA biosynthesis in E CS SMO PMC9163322__F1 Novel Immune Checkpoints in Esophageal Cancer: From Biomarkers to Therapeutic Targets TIGIT LAG3 PMC7653260__F4 Signalling pathway of programmed necrosis in hearing loss TRADD TNF FADD MLKL PMC7653260__F3 Signalling pathway of autophagy in HL ULK1 ATG12 MTOR PMC8345080__F1 Osteopontin as a Regulator of Colorectal Cancer Progression and Its Clinical Applications RUNX2 BMP2 TGFBR1 APC GSK3B TGFBR2 SMAD4 DSPP DMP1 BMPR2 LEF1 NR1i1 PTCH1 ME3 SMAD1 TCF4 PMC2702150__F3 FIBROTIC DISEASE AND THE TH1/TH2 PARADIGM TH IL13RA1 PLG MMP9 NOS2 CD36 PMC8479066__F6 Receptor tyrosine kinase ROR1 ameliorates AB1–42 induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer’s disease TH ROCK2 MAP2 ARHA PMC6940991__F3 Mutant p53 GOF and hypoxia MDM2 ARHA PMC6940991__F2 Mutant p53 gain of function (GOF) in metabolism and invasion CCNB1 CCND1 ARHA CCNG2 STAT3 PMC7753939__F5 Top significantly related pathways of “herb-ingredient-target” networks in JZD against NAFLD: (a) nuclear receptor transcription pathway; (b) regulation of lipid metabolic process TLR4 HNF4A IL3 F2 TYMS NR1C2 S100A13 TNF PPARG NR1C1 FGFR2 PMC6906418__F1 Intracellular sensing of viral genomes and viral evasion TBK1 USP4 USP15 UBE2D3 USP21 MEX3C TRAF3 FBXW7 DHX29 USP14 CYLD ZCCHC3 RNF123 IRF7 RNF122 SSB RIOK3 IRF3 TRIM4 TRIM25 TRIM65 RNF125 TRIM40 TRIM13 TRIM38 STAT4 ARL5B MAVS LRRC25 PMC3820944__F6 Representative Tyr phosphorylation sites affected by erlotinib in the EGFR and ErbB2 canonical pathways PIK3R1 PLCG1 INPPL1 EGFR ERBB3 MAPK3 GSK3A PIK3R3 GRB7 ERBB2 PTPN11 GRB2 SRC SHC4 MAPK1 CDC2 SHC1 PXN PIK3R2 VAV2 PMC5899637__F1 Drug resistance in HER2-positive breast cancer brain metastases: blame the barrier or the brain? TSC1 PTEN PMC10635689__F8 BJ-5ta Exo exert a protective effect against UVB-induced photoaging COX2 RAD51 TGFB1 PMC7295987__F4 Outline of the signaling pathways activated by CpG CD14 TLR9 IRAK1 LYN IRAK4 MYD88 PDPK1 CD19 PMC6412245__F9 Schematic diagram shows the therapeutic effects of ergosterol on diabetic nephropathy SMAD2 SMAD4 PCNA PMC6906418__F2 Intracellular sensing of viral genomes and viral evasion TRIM41 CGAS HDAC3 IRF7 RNF185 IRF3 SENP2 OASL TRIM14 TRIM38 SENP7 TRIM56 TTLL6 TTLL4 ZCCHC3 PMC11771162__F3 Statins exhibit pro-angiogenic properties BMP2 RHO PMC6825561__F1 Proposed scenario of current strategies targeting different traits of dysfunctional mitochondria in Alzheimer disease (AD), including mitochondrial bioenergetics and mitochondrial homeostasis ULK1 NRF1 APP ULK2 MTOR TFAM SIRT1 PMC3538421__F3 Summary of P450 enzymes in cholesterol and bile acid biosynthesis CYP27A1 CYP46A1 CYP8B1 CYP3A4 CYP7B1 CYP51A1 CYP7A1 PMC11998530__F8 Abortive PDCoV infection triggers Wnt/Beta-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance APC GPR49 PMC11432203__F7 Causality of CD4+ TEM markers and PTB and COVID-19 infection based on MR analysis (by Figdraw 2 GBP2 LAG3 PMC8116604__F4 Evolving landscape of N6-methyladenosine modification in the tumor microenvironment METTL14 METTL1 PHLPP2 PC METTL3 ATF4 GC MYC ALKBH5 PMC3397898__F6 Signaling pathways that regulate cAMP-mediated WPB exocytosis RALA PMC4863711__F2 An overview of different signaling pathways activated by high glucose ambience, which leads to an altered expression of various ECM glycoproteins, and of genes relevant to EMT and apoptosis processes TLR4 APC EEF2 S100A8 GSK3B MYD88 MTOR PMC3538421__F5 Diagram showing the fundamental steps and P450 enzymes involved in vitamin D biosynthesis and degradation pathway NR1i1 CYP2R1 CYP24A1 CYP27B1 PMC3634798__F1 Stress response pathways GSTT1 AHR GSTM1 GPX1 PON1 CYP1A1 PAH CYP2E1 NQO1 HEL-S-22 PMC8728107__F2 Neural regulations of the tumor microenvironment SRC CALCRL RAMP1 PMC3717064__F1 NK cell activating and inhibitory receptors and their downstream signaling molecules FYN PC LCK ZAP70 GRB2 LILRB1 SYK LAIR1 LAT PMC8728107__F1 Neural regulations of the tumor microenvironment SRC STAT3 GATA1 PMC8891342__F3 Impact of intracellular innate immune receptors on immunometabolism NLRX1 TRAF6 TNF MTOR AIM2 NLRC3 FOXO1 IFNG FOXP3 PMC8027849__F1 Resistance to CDK4/6 inhibitors FBXO4 FGFR1 HGF CDK2 MYC CDK4 LATS1 SPOP MTOR FAT1 CDK6 STAT3 PMC9316979__F7 Transcriptome Analysis Reveals Key Gene Expression Changes in Blue Catfish Sperm in Response to Cryopreservation INA BAD AIP CS USP21 IRF9 RIPK3 CASP2 TNF TLR3 ZBP1 CASP3 NLRP3 IL18 ATM CYLD CAD H2AX OSM FADD MLKL PMC8989532__F8 RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences TEC RHO PMC2889604__F7 The regulation of neuronal migration and neurite outgrowth by the MRTF/Srf pathway PAK1 CDK5 RHO PMC4123481__F3 Role of STAT1 and STAT3 in Foxp3 expression and cytokine production in Tregs STAT1 IFNG STAT3 FOXP3 PMC5615630__F7 RSV inhibiting NKTCL cells BAD ATM STAT3 BAX PMC4498148__F1 WNT pathway is significantly upregulated in invasive mutant TP53 cells BAMBI EGR1 CCNA2 SOX2 KRT19 WNT1 CCL7 DKK1 ID3 CCND2 MMP3 PCDH9 SCD EVI1 DIXDC1 MME PMC12018449__F1 AS-IV in the pathogenesis of arrhythmia MAF NLRP3 TLR4 KEAP1 GPX1 BAX PMC6795678__F1 Scheme of the parietal cell of a gastric gland CCK CASR HEL-S-11 PMC9131857__F9 Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly NLRP3 TRAF6 MYD88 PMC22753__F6 A signal transduction pathway leading to the phosphorylation and activation of mTOR in response to insulin PDK2 MTOR PMC7053123__F4 Gemcitabine resistance and metabolism MUC1 HEL-S-26 NAMPT LAT2 RRM2 FBP1 USP9X MTOR FASN STAT3 PMC6541752__F1 Comparison of nucleic acid signalling pathways leading to type I interferon (IFN) production in an autoimmune disease and bacterial infection TBK1 CGAS TLR4 TREX1 IRF3 NOD2 PMC5374984__F1 The autophagy pathway ULK1 AMBRA1 MTOR PMC3042782__F2 Models for HJV cleavage by furin-like activity and matriptase-2 BMP6 FURIN PMC9312358__F4 Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases VCAM1 NOTCH1 HEL-S-44 SIRT1 HES1 SIRT3 PMC6896241__F1 Representation of causal interaction data in a standardized format KIF7 MYC SMO PMC8998102__F3 Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism NLRP3 IL18 BMP7 GSDMD PMC3857153__F8 Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells SOCS2 PCSK9 BRAF BIRC3 TNF TNFAIP3 TRAF2 CITED2 PMC3157269__F3 Sensing the HP-PRRSV infection by host cell STAT1 TLR8 TLR7 IRF7 IRF3 NMI MYD88 SARM1 SBNO2 TLR3 SOCS1 PMC10181252__F1 Wnt/Beta-catenin signaling pathway in tumor progression APC GSK3B PMC11172503__F2 Anti-senescence effect and molecular mechanisms of royal jelly (RJ) and its components on cellular senescence, healthy aging, and longevity induced by endogenous and exogenous factors ATM CDK2 CDK4 ATR CDK6 PMC4926373__F1 Schematic overview of DNA damaging agents, radiotherapy, DNA damage, the cellular response upon DNA damage, genetic variation, epigenetic regulation and cancer therapy response ATM RAD51 PARP1 ATR H2AX BRCA1 PMC6791057__F2 Mechanisms underlying the sex-specific establishment of the Wolffian duct EGF FGFR1 EGFR ETV4 ETV5 FGFR2 PMC11172503__F1 Nrf2 and NFKB signaling pathways by royal jelly (RJ) MAF COX2 MMP2 MMP9 TNF NQO1 PMC10439834__F1 IL-17 signaling pathway: transduction and amplification TRAF5 EBP TRAF2 TRAF4 PMC10181252__F2 Various flavonoids on the Wnt/Beta-catenin pathway APC GSK3B PMC4979424__F8 Proposed model of VacA effects on Cx43 and autophagy, followed by apoptosis ATG16L1 EEA1 RAC1 PMC9272004__F2 Heme Synthesis by Mitochondrial Homeostasis Proteins ABCB6 FECH UROD SLC25A38 UROS HMBS CPOX CLPX TMEM14C ABCB10 PMC7364656__F7 Sal and Das together synergistically inhibited the BRCA1 pathway in the MDA-MB-468 cell line STAT1 PLK1 ATM ATRIP MSH6 BARD1 ATF1 RAD50 ENG ATR MRE11A BACH1 PMC5938062__F6 TAK-733 under an Ang II-induced signaling pathway in vascular remodeling VCAM1 CCND1 PMC9456253__F4 Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons NRF1 E2F6 PAX2 CREB1 RPL13 NR2F1 TAF12 RPS24 STAT1 TAF11 LSM7 TAF7 FOXL1 SREBF2 EN1 IRF2 TAF6 RPL3 TAF4 FOXF2 TAF10 USF2 TP63 MAX YY1 AK6 TAF5 RUNX2 POU2F2 RPL11 ZNF354C FOXA1 NKX3-2 RPL10A TFAP2A RPS6 JUN GATA3 NFYA RPLP0 TAF1 ARID3A NR3C1 RPL6 RPS8 GATA2 HNF4A NFKB1 RELA TFAP2C RPL5 PPARG STAT3 PMC6664006__F8 Proposed model to explain how COX-2 might be essential in the stimulatory pathway for ROS production and increased expression of profibrotic genes mediated by PRR activation SMAD2 NOX4 PMC529535__F1 Two models relating Akt and Tsc2 in cell growth control in Drosophila TSC2 TSC1 PTEN RHEB PMC4333106__F2 Canonical and alternative androgen biosynthesis pathways STS SULT2A1 CYP11A1 CYP17A1 PMC5753567__F1 Relation between activated WNT/Beta-catenin pathway and Warburg effect in ASD APC LRP5 LRP6 HEL-S-133P PMC8377336__F3 On the nutritional and therapeutic effects of ketone body d-Beta-hydroxybutyrate NLRP3 PDC FFAR3 PMC4429755__F1 Regulation of miRNA biogenesis as an integrated component of growth factor signaling DGCR8 DROSHA GAA PMC4429755__F3 Regulation of miRNA biogenesis as an integrated component of growth factor signaling DGCR8 DROSHA PMC8552790__F9 Schematic diagram of GTF2F2 related functions MAX MYC BCL2 CDC2 CDK9 BAX PMC8585009__F5 Diagram depicting the 2 branches of the fat remodeling program controlled by neuronal activation of Hsf-1 TF ERAF PMC8170687__F1 Integrin function is regulated by conformational activation and vesicular traffic and is crucially involved in mechanosensing and TKR signaling GGA2 CD44 RAB13 PMC9505042__F7 TGFB/SMAD Signaling Pathway Prevents Follicular Atresia by Upregulating MORC2 SMAD2 TGFBR1 TGFBR2 SMAD4 BCL2 MORC2 BAX PMC7893589__F3 Effects of miR-320 on glucose and lipid metabolism in cardiomyocytes AGO2 IGF1 CD36 PMC9348444__F4 Comprehensive role of SARS‐CoV‐2 spike glycoprotein in regulating host signaling pathway NRP1 TLR1 ACE2 TMPRSS2 PMC7571393__F2 Summary of the regulatory network and mechanisms of circ_ASPH in CCA cells.Abbreviations: ASPH: aspartate B‐hydroxylase; CCA: cholangiocarcinoma ASPH ABCG1 PMC3045450__F4 NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs TSC2 RPS6KB1 TSC1 HEL-S-67p PIK3CA PTEN EIF4E EIF4EBP1 FOXO1 RHEB PIK3R2 PMC5242433__F6 Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial ORC6 CDK2 MDM2 SMAD4 DBF4 CDK7 PCNA CDC45 SKP2 MYT1 PMC10886007__F3 TGFB/SMAD signaling pathway BMP2 SMAD2 SMAD6 SMAD4 BMP7 GDF11 SMAD1 DKFZp781O1323 BMP4 PMC10886007__F2 Mitochondria-dependent apoptosis pathway BCL2 HTRA2 BAX PMC9604720__F1 Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review MMP2 PLG MMP9 FURIN BDNF PMC3552884__F8 Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells EEF2K ATF4 MTOR DDIT4 PMC10886007__F5 PI3K/Akt/mTOR signaling pathway TSC2 TSC1 PTEN FOXO1 RHEB BAX PMC5661609__F1 Dysregulation of KRAS signaling pathway in PDAC tumors compared with that in the paired adjacent non-malignant tissues BRAF RASA2 RALA MAP2K2 ARHA PTEN RALBP1 MTOR GNAI1 PRKCA PAK1 MAP2K1 GNAI3 GRB2 SRC PIK3CA RAF1 SOS1 SHC1 ARAF PMC10886007__F4 AMPK/SIRT1/PGC-1A signaling pathway NRF1 KEAP1 TFAM SIRT1 PMC4895609__F1 Simplified schematic illustration of PI3K/Akt and mitogen‐activated protein kinase (MAPK) signaling pathways in thyroid cancer BRAF PTEN MTOR PMC9418004__F8 Mechanistic illustration showed PLAA-METTL3-TRPC3 axis in ovarian cancer METTL3 PLAA TRPC3 PMC6855007__F10 Illustration representing the mechanisms of compound 1-induced human breast cancer cell apoptosis BAD ATM EGFR ATR PMC9163393__F3 Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression EGF MMP2 UCK2 EGFR STAT3 PMC5973841__F2 Filoviruses inhibit the type I IFN response at multiple steps STAT1 TANK STAT2 IRF9 TRAF3 TYK2 IFNAR2 MYD88 JAK1 IFNAR1 MAVS PMC7854502__F5 Developmental pathways in liver cancer PIG59 IHH RBPJ IGF2 opn NR1C1 SOX9 PMC7826004__F3 Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms SI ACE2 TMPRSS2 PMC9657162__F8 Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood–Milk Barrier NLRP3 ATG16L1 ATG12 DKFZp686F0183 PMC5655367__F4 Modulations of adaptable responsive genes in acclimation MLNR CDA EGF NRG3 BAD INS MYC LPA MTOR TRPV1 INSR BTC GHR SRC LEPR TRHR JUN GHSR NRG2 SHE HBEGF NRG1 SCTR LTB4R TACR2 CRK IRS1 CBL MAFA GCGR LEP OXTR PRLR GRB2 MC2R GHRHR FSHR PMC2939362__F1 Domain organization of proteins in the Hh signaling pathway HHIP EGF BOC SMO GAS1 PMC7793976__F1 Action of emapalumab STAT1 JAK1 PMC7852140__F3 Metabolic pathway of norvancomycin biosynthesis up-regulated in high-yield strain CIT MAL PMC6059757__F15 PPI networks for key KEGG pathways HLA-E NMUR1 CD99L2 RUNX1T1 TBX3 F2RL3 CSF3R JAM3 FGFR4 SPN FGFR2 BMPR2 CADM1 GHR NR1A2 P2RX6 CD34 CLDN18 PTGER4 RXRG AVPR2 CHRNA2 ID3 ADCYAP1R1 SMAD9 PIK3R5 SIGLEC1 DAPK2 LEP WNT3A COL4A3 CDKN2B CHRM1 WNT2B CXCL12 NTNG1 RASGRP4 ADCY9 PMC5074086__F1 Pheochromocytoma: The First Metabolic Endocrine Cancer CS FH ACLY MDH2 PMC11627363__F7 Golgi apparatus stress response pathway activated by AIV infection ATP6V1A ST3GAL6 MGAT2 PMC3289121__F5 IPA illustrating the predicted effect of milk removal on PI3K signaling in T lymphocytes DAP PTEN BLK PMC6021929__F5 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants FGA EPO PRSS53 F5 ABO PMC7870789__F1 Tumorigenic mechanisms in somatotroph cells AIP GIPR GPR101 GHRHR PMC5370075__F4A Biomechanical relationships between the corneal endothelium and Descemet’s membrane LATS1 RHO LPA LATS2 PMC9951170__F2 When AHR signaling pathways meet viral infections AHRR AHR SRC PMC8899182__F2 Regulation of PBXs and their emerging role in cancer USP9X PBX2 PBX1 PBX3 NOTCH3 STAT3 PMC3192251__F2 NPC and CF converge on multiple intracellular trafficking pathways NPC1 NPC2 CFTR PMC9576519__F9 Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways NTF3 HDAC3 HDAC1 PMC6274888__F1 Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function CXCR4 SHH ARG1 PMC9598694__F9 Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFKB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats IL10 TLR4 SIRT1 BAX PMC5838032__F5 Overview of the metabolism of sugars, amino acids, and related compounds GAL AMT PMC6157734__F2 Human CARD9 signaling pathway CXCL1 CARD9 BCL10 SYK CXCL2 IL6 HRAS CSF2 IL1B PMC7648118__F2 Therapeutic strategies targeting the NMJ in dystrophic muscle MUSK LRP4 RAPSN GABPA PMC3634610__F2 Signaling network of Dectin-1 NLRP3 CARD9 BCL10 RELB SYK PLCG2 PMC6711424__F1 CNVs, SNVs/indels on histamine‐related metabolism and signalling pathways MAPK12 MAPK13 BIK MAPK11 VAMP8 HEL-S-93 SLC22A2 HDC PMC6021929__F2 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants SBSN TNIK RASGRF2 PDE3A VCAN RGS2 EMCN DLG4 PMC3634610__F3 ITAM-like-bearing CTLRs within the Dectin-1 cluster SYK PLCG2 TNF CLEC9A PMC5943343__F7 Proposed Model: The figure shows that mutation in GNE inhibits sialic acid synthesis that may cause hyposialylation of IGF-1R GNE BAD IGF1 BCL2 PMC8071448__F2 Examples of functions of human disease-related retrocopies PTEN CP INSR HMGA1 PMC9226217__F2 Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells CD14 MYD88 TLR1 MAL PMC8351721__F7 Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer LIMK1 APC AVP RHO CDC42 PMC9603894__F1 Oncolyic Virotherapy for Prostate Cancer: Lighting a Fire in Winter IRF7 TRAF3 IRF3 PMC8790913__F8 SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration HLA-DPA1 HLA-DPB1 CSF1R FCER1G CX3CL1 HAVCR2 CCL4 TNF HLA-DMB TF HLA-DMA TYROBP PMC8750882__F12 Extracellular Vesicles Derived from Bone Marrow in an Early Stage of Ionizing Radiation Damage Are Able to Induce Bystander Responses in the Bone Marrow BAMBI NLK CTBP2 LRP5 WNT10B FZD5 PMC11266911__F2 Molecular mechanism of antitumoral properties of 6‐shogaol CCNB1 NOTCH1 CCND1 CSA2 CDH2 MTOR CCND3 PCNA STAT3 BAX HES1 PMC6510997__F1 Immune signaling network in MS HEL-S-102 FOS RELA INS SRC NTRK2 JUN TIRAP IFNG INSR PMC6414715__F10 Activation of antiviral pathways in Atlantic cod TANK TLR9 IRF7 TRAF3 TRAF6 IFNGR2 IRAK4 IRF3 MYD88 PELI1 TLR3 IFNG NFKBIA TLR7 NFKB1 FADD TAB3 PMC5010470__F1 NF-kB signaling pathways HELB RELA RELB CSA2 TNFAIP3 PMC9014844__F3 Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption NPY AgRP IFNG PMC9306208__F4 Senescence in osteoarthritis: from mechanism to potential treatment HLA-E ATM DPP4 MICA ATR IL6R PMC8780935__F3 Research progress on the hedgehog signalling pathway in regulating bone formation and homeostasis HHIP IHH RUNX2 BMP2 WNT1 GSK3B BMP7 BMP4 SUFU ATF4 SHH GH1 SMO PMC6092675__F8 Inhibition of mTOR activity with rapamycin SMAD2 TGFBR1 SMAD4 MTOR PMC3365794__F2 Model showing arterial, venous, and lymphatic cell fate specification in the developing embryos SOX18 PROX1 EPHB4 NRP2 PMC7333391__F5 Postulated mechanism by which CagA promotes the expression of IL-6 in gastric cancer EEF1A1 OSM OSMR STAT3 PMC4827621__F9 Deletion of KvB1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts KCND2 IL1B GATA4 KCNAB1 MYH6 PMC3311240__F11 Muscle cell signaling in response to 1E3 PAK1 SOST GRB2 RAC1 CDC42 PMC3978640__F6 Blocking the transforming growth factor B (TGFB) signalling pathway SMAD2 TGFBR1 SMAD4 PMC3324906__F1 Pivotal role of E-cadherin, Beta-catenin, and transforming growth factor B (TGFB) and Wnt signaling pathways in an epithelial-mesenchymal transition (EMT) program SMAD2 APC GSK3B SMAD4 PMC8693183__F5 Gill Transcriptomic Responses to Toxin-producing Alga Prymnesium parvum in Rainbow Trout MAPKAPK2 A2M CRP LBP MAP3K7IP1 TRAF2 STAT3 PMC9013079__F8 L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKBeta-AMPK signaling pathway CPT1A MTOR TG NR1C1 FASN PMC8267469__F7 Systems Pharmacology–Based Dissection of Anti-Cancer Mechanism of Traditional Chinese Herb Saussurea involucrata EGF BAD TRAF3 IL6 TNF MTOR IL6R RXRA COX2 LTA MDM2 SRC CASP9 RPS6 TRAF2 STAT3 PMC5075921__F4 Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data IL1A MAP3K1 IGF1 MAP3K7 TGFA PMC6882011__F4 Pathway display visualisation of significant changes in primary/intermediary metabolite abundances observed between COL2246 and ECU72 during the infestation cycle UNK IPP PMC8317513__F5 FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/Beta-Catenin Signaling Pathway FHL1 MMP7 LEF1 APC GSK3B AXIN1 LRP5 CCND1 LRP6 CDK4 TCF4 PMC5260790__F3 Differential methylation network of schizophrenia GNB2 MIOS RNF213 POLR2H FPGS BMF MYH10 ZC3H10 HEL-S-94n MNT TBP TLE4 SHH SMO AKAP10 IRF2 HOXC13 GPR37 KLHL20 ELK3 MED4 HHIPL2 TUBB EEFSEC NDUFA6 IRF2BPL MAP3K7 GNA13 NPPC CPNE3 MGME1 ARHG PRKCB GABPB2 PAOX SUCLG1 ADAM10 TMOD3 CDC73 BATF3 ANKRD11 PRDM14 TMEM30A EDRF1 BLM DDX47 ZNF322 BACE2 GTF3A RPL27 LRRC41 PTPRN2 RBM14-RBM4 ZNF830 INPP4B EIF4EBP1 GIT2 FOSL2 RCOR3 MPHOSPH6 SUGP1 HOXA11 DCAF10 HEL-S-67p DIS3L2 DLGAP2 P2RX6 RAMP1 FASN CLCN2 RNF123 AATF PROX2 CAMK2G FUS CD320 ASNS HOXA1 NDUFA10 AGL PMC9409657__F6 Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis FADD SIRT1 BAX PMC2757955__F10 Proposed model of IGFBP-3 modulation of growth factor receptor activation mediated by S1P EGF EGFR SPHK1 SKI PMC2100073__F6 Filamentation signaling pathway recovered completely FAR1 CDC42 PMC86880__F1 Receptor proximal signaling pathway for IL-1 TRAF6 MYD88 PMC6585752__F2 Characterization of network connectivity between highly expressed interferon (IFN) response genes IFIT3 IFIT2 RSAD2 HERC6 CMPK2 EIF2AK2 IFIT5 ZCCHC2 MX1 USP18 OASL SIGLEC1 OAS1 OAS2 OAS3 XAF1 PARP12 EPSTI1 IFIH1 IFI6 IFIT1 PMC8047301__F3 Leucine sensing signaling pathway upstream of mTORC1 and the potential role of exercise TSC2 FLCN RHEB PMC2949481__F2 Insulin, IGF-I and IGF-II signaling through the IGF-IR TSC2 BAD TSC1 MDM2 GRB2 PTEN MTOR IRS1 RHEB PMC7035994__F2 Polarity proteins in oncogenesis LLGL2 SCRIB DLG5 PMC3073074__F1 The pathway of propionyl-CoA to succinyl-CoA metabolism is displayed MCEE MMAA PCCA PCCB PMC4163915__F11 Model is presented whereby serine phosphorylation of IRS-1 serves as a mediator of Ang II to inhibit insulin-induced Akt Thr308 phosphorylation EGFR INS HBEGF MTOR PMC7035994__F1 Apico-basal polarity proteins play a critical role in homeostatic control of cell density PATJ LLGL2 SET MARK4 PALS1 MARK1 DLG5 LLGL1 PMC4564397__F1 HOCl signaling pathway A LPO PMC1526464__F8 Bile acid and cytokine inhibition of CYP7A1 gene transcription HNF4A IL1B CYP7A1 PMC6230871__F7 Differentially expressed miRNA-mRNA pairs in nuclear factor of activated T cells (NFAT) cardiac hypertrophy pathway from NHE1 transgenic mouse hearts IGF1R IGF1 DAO LIF GSK3B GRB2 CTF1 NACA2 CRAT GAL PMC4564397__F2 The NO/peroxynitrite signaling pathway A LPO POR PMC4564397__F4 Salicylic acid and anthocyanidins use different strategies to inhibit tumor cell protective catalase NONO H1-5 CPD PMC6230871__F3 Genes altered in NHE1 transgenic hearts were enriched in KEGG hypertrophic cardiomyopathy (HCM) pathway SGCG SGCA SGCD MYL2 MYL3 TNF SGCB DMD MYH6 PMC6360084__F8 Identification, expression, and phylogenetic analyses of terpenoid biosynthesis-related genes in secondary xylem of loblolly pine (Pinus taeda L.) based on transcriptome analyses PMVK MVD MVK IPP PMC3793031__F2 Symbiotic signaling downstream of oscillations ERN1 MYC PMC8847772__F1 Search for Biomarkers and Treatments in Chagas Disease: Insights From TGF-Beta Studies and Immunogenetics SMAD2 SMAD4 PMC6340093__F1 Interacting enzyme in the monolignol biosynthetic pathway RP1 RAC1 CAD ACD PMC7022462__F2 Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression APC MTOR PMC10532123__F6 Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells SOX2 NCL PDGFRA CER1 MESP2 FZD4 DKK1 GATA4 ISL1 MYH6 MESP1 KDR NKX2-5 TBX5 POU5F1 PMC3809361__F1 Metabolism of cancer cells is regulated by signaling pathways related to oncogenes and tumor-suppressor genes TIGAR SCO2 MYC PTEN MTOR PMC3979678__F3 Global Changes in Gene Expression of Barrett's Esophagus Compared to Normal Squamous Esophagus and Gastric Cardia Tissues CD9 TJP1 SST IL13RA1 CAST IL1RN DST HEL-S-53e CA9 CCNG2 NR2F2 SPRR1A IL18 ZFP36 MUC4 PMAIP1 MCL1 TMOD3 TGFA SERPINB2 TGFB1 CD36 PMC7693871__F7 The pathway of Ac2-26 effect: (A) the mechanism of the anti-inflammatory responses of Ac2-26 in HaCaT cells STAT3 PMC6978911__F8 Schematic comparison between CiTLR22a- and CiTLR22b-mediated signaling pathways IRF7 IRF3 MYD88 IRAK3 PMC11534861__F2 Histone lactylation in cancer HEL-S-133P PER1 GPR37 BZW2 PMC8431490__F3 The BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin VCAM1 VEGFA LTBP1 STAT3 BAX PMC6249275__F3 Keap1-dependent and Keap1-independent mediated Nrf2 signaling MAF AHR KEAP1 GSK3B RBX1 PMC6249275__F1 Natural products activating Nrf2 signaling pathway KEAP1 ABCG1 ABCA1 RBX1 CD36 PMC8087812__F2 Response of green leaf volatile (GLV) biosynthesis in MeJA-primed fresh tea leaves ALDH2 PMC4592906__F2 TNF-induced programmed cell death pathways TRADD CYLD TNF FADD MLKL PMC8247436__F4 Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection MICA CD40 MYD88 PMC8056770__F1 Pleiotropic roles of leptin in metabolism, immunity, and cancer SOCS3 LEPR MTOR STAT3 FOXP3 PMC8841363__F2 Network based systems biology approach to identify diseasome and comorbidity associations of Systemic Sclerosis with cancers CXCL1 PKIG THBD VSIG4 AZIN2 MSR1 MMP11 CXCL3 MRC1 G0S2 MTAP NAV3 JDP2 C1QA COL16A1 ADI1 COL12A1 CD163 PKIA APIP COL9A1 SAT2 SMS TRIO AGMAT CD14 PYROXD2 CXCL2 IL6 AMD1 COL5A2 C1QB EDNRB SRM SMOX PKIB PAOX CPSF1 RNPC3 CD93 C1QC COL10A1 ALDH2 PMC4329480__F1 Molecular mechanisms regulating mitophagy HEL-S-62p PINK1 CLEC16A BNIP3 USP30 PMC11534861__F4 Relevant mechanisms of lactylation in the development of cancer by modulating TME METTL3 VEGFA HIF1A FOXP3 PMC2981143__F1 Folate metabolism and its contributions to physiological processes DHFR PEMT PMC4423527__F1 Neddylation pathways influencing NFKB and HIF-1A IFNG PMC5319840__F3 Tgfbr2 cKO CD34+ SCC cells upregulate genes implicated in invasive human cancers CORT C4B_2 TPR WAS CCL2 EVI2A DCN LCP2 COL14A1 CFD opn RASSF2 GAL FGL2 SLA CFB FTH1 MMP9 NID2 APOB OGFR EDNRB RECK C6 HEL113 TNS1 SRGN CP PMC2640984__F3 Distribution between short and long flap removal pathways FEN1 DNA2 PIF1 PMC3181439__F1 Jun N-terminal kinase signaling pathway ATF2 APP GCK KNS2 HSF1 TRAF2 DUSP19 STAT3 BAX PMC6831194__F5 Discovery of metabolic pathway identified in both optimal cutting temperature-embedded and formalin-fixed paraffin-embedded samples CDA EPO UCK2 GDA UMPS PC PARS2 AID GPT2 ARG2 PKLR XDH APOBEC4 ME3 CAD DLAT ADK GLS2 DLD UCK1 GUK1 ASNS ADA APRT DHODH GLS PMC4834538__F7 Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis WNT3A NFATC1 PMC10758155__F6 Huaier suppresses cell viability, migration and invasion in human non-small cell lung cancer via lncRNA DLEU2/miR-212-5p/ELF3 axis ELF3 NOTCH3 PMC11988921__F1 Unfolded protein response (UPR) signaling pathway consists of three major branches: activating transcription factor 6 (ATF6), inositol-requiring enzyme-1A (IRE1A), and PKR-like ER kinase (PERK) ATF4 TRAF2 XBP1 PMC9199543__F3 Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective SIRT2 COX1 HDAC2 MTOR BDNF PTGS1 HDAC1 PMC5905465__F1 Structure of NFKB members.Notes: The NFKB family consists of three proteins with a transactivation domain (RelA [p65], cRel, and RelB) and two proteins lacking a transactivation domain (p105/p50 and p100/p52) RELB CD40 LTBR PMC4084552__F1 IL-33/ST2 signaling pathway SIGIRR IL33 TRAF6 IRAK4 MYD88 PMC2932466__F3 Signal transduction mechanisms involved in the mediation of cellular responses induced by secreted MIC-1 cytokine in certain cancer cells EGFR SMAD4 ARHA PMC7066027__F5 Roles of miR-30c family members in drug resistance TWF1 EGFR HEL-S-93 PMC7066027__F4 Roles of miR-30c family members in carcinogenesis, metastasis and invasion TWF1 HEL113 PMC1380241__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1–COQ8 COQ3 COQ2 COQ6 COQ5 COQ7 PMC4928589__F2 Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective RICTOR ULK1 FOXO3A MTOR DEPTOR PMC11049089__F1 Signaling cascades of TLR4 and TLR2 receptors FOS IRAK1 TRAF6 IRAK4 IRF3 LY96 RAC1 MYD88 RIPK2 TNF NOD2 LTA NOD1 JUN SOCS1 PMC5520418__F2 PTEN functions in T-cell development, activation and differentiation APC PTEN PMC8999457__F2 Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System TBK1 IRF7 IRF9 IRF3 IRF-1 TLR3 MAVS RNF125 PMC1383660__F6 Intracellular signalling pathways activated by leptin PDE3B NPY ARHA CEBPA STAT3 PMC8290198__F1 Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events PLCG1 ITK LCK GRB2 HEL-S-81p CD69 PMC1383660__F5 Intracellular signalling pathways activated by leptin PI3 EGR1 GRB2 PMC2494808__F3 Graphical representation of connections between receptors and pathways implicated in NTS baroreflex modulation by pharmacological studies TSC2 BAD FRK MDM2 GRB2 ADM CDC42 PMC1829419__F4 Hypothetical regulatory network influencing honeybee pollen foraging behavior modulated by insulin-like signaling and its effects on ovarian development PIN1 PIN4 PTEN PMC4682888__F2 Integration of Akt and mTORC1 signaling into the IL-4R and TLR4 pathways TLR4 JAK3 JAK1 PMC4518158__F1 Unfolded protein response ATF4 EIF2A XBP1 PMC7277983__F2 TNF-TNFR2 signalling pathway in the immunosuppressive cells RIPK1 TNF TRAF2 PMC7400846__F2 Cholesterol and bile acid biosynthesis INSIG1 SP2 ABCG8 ABCG5 LDLR SHE SP1 ABCB11 ACAT2 PMC7564116__F3 Functions of circRNAs in colorectal cancer (CRC) CDK6 PMC7007672__F3 Molecular pathways in embryogenesis of the liver HNF4A TBX3 SMAD4 ONECUT2 CEBPA PROX1 GATA4 HHEX PMC8859251__F9 Biomarker Value of miR-221 and miR-222 as Potential Substrates in the Differential Diagnosis of Papillary Thyroid Cancer Based on Data Synthesis and Bioinformatics Approach TSC2 BAD DAO SI SRC PFKP GATA4 PMC9686346__F3 Health benefits of Nigella sativa on diabetes mellitus and its complications: A review from laboratory studies to clinical trials IGF1 LPO TG BAX PMC2885511__F2 Diagram of PDGF-D cross-talks with other pathways PDGFD PLG MTOR PMC8068079__F2 Base excision repair, nucleotide excision repair and mismatch repair pathway POLE XPC POLG PARP1 PCNA PMC8615493__F6A Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3Beta-Tau Complex to Impair Insulin Signaling Transduction GRB2 BDNF IRS1 PMC2782433__F1 COPPER ACTIVATION OF NFKB SIGNALING IN HEPG2 CELLS ANGPT2 MXD1 MARCKS PLK3 HIVEP2 SQSTM1 HEL-S-101 RELB NPPB KLF5 TTN POP7 DUSP5 VLDLR P2RY6 NFKB1 CCL20 MAP3K8 HEL114 THBS1 GRB10 PMC8502815__F7 Beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity CD14 TLR4 CRP TNF IL1B PMC8636732__F2 Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors PAK1 HGF SMAD2 ZEB2 APC EGFR GSK3B SMAD4 CDH2 HIF1A PEMT PMC4509066__F2 Signaling pathway of cell apoptosis under cordycepin stress TRADD APAF1 FADD BAX PMC6874977__F3 PPI network analysis CXCL1 AGTR1 APLN CXCL8 PPY CXCL3 GPR4 SAA1 GNGT1 CCR8 GCG PPBP HCAR3 CNR1 GALR1 PROK2 GNG4 UTS2B NPY CXCL6 CCL28 GAL NPSR1 INSL5 F2RL2 CXCR1 NPY1R SST PMCH FPR1 FPR2 CXCL2 SSTR2 OXTR CHRM1 CXCL12 PMC9408960__F1 Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases EDARADD TNFRSF9 EDAR TFG LTB RELB TRAF6 TNLG7C PMC10179184__F2 Mechanism of CYLD function in oxidative stress-induced DNA damage CYLD OTULIN PMC11332896__F2 Signaling pathways involved in muscle atrophy during cachexia IGF1R IGF1 SMAD2 IL6 MTOR PMC10236263__F6 Models of the positive regulatory feedback loop of p65/miR-27a-3p/TAB3/NFKB axis TRAF3 MAP3K14 TAB3 PMC4357015__F1 Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi PC PSD PMC8394995__F2 BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme ATM EGFR MYC RAD51 VILL KDM4B PTEN MTOR ATR KDM4A PMC7857921__F4 Selected pathways up- and downregulated by the additional hemorrhagic shock CD14 C5AR1 ADAM9 TLR4 S100A8 S100A9 TIRAP CCL3 PMC9537693__F8 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid inhibits angiogenesis via modulation of vascular endothelial growth factor receptor 2 signaling pathway VEGFA CCND1 ARHA STAT3 PMC11909752__F8 The proposed mechanism for chronic adrenergic stimulation induced heart failure via cAMP-PKA-PDE4D signaling pathway and protective mechanism of PDE4D inhibition PDE4D PINK1 SIRT1 PMC4876997__F6 Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15 EGR1 IHH NR1i1 RUNX2 PRKAR1A PTCH1 SHH CREB1 PMC524028__F2 Regulation of the mTOR signaling pathway TSC2 TSC1 EIF4E RPS6 RHEB PMC12055817__F2 Possible mechanisms underlying crosstalk between microglia and astroglia NLRP3 AHR CX3CL1 CXCL10 CCL2 NOS2 VEGFB TGFA PMC11772370__F3 Protein lactonylation modification is an important influence in the process that is HIF-1-mediated HMGB1 activity HMGB1 TLR4 PTEN MYD88 MTOR HEL-S-68p PMC12055817__F3 Antidepressant mechanism of natural anti-inflammatory products NLRP3 TLR4 BDNF PMC3755464__F3 Recombination-independent interstrand crosslink repair pathway in vertebrates REV1 XPC PMC5354803__F3 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis COX2 MDM2 DHCR24 CCND1 NR1C1 PMC11772370__F1 Metabolic crosstalk between neurons and glia involving lactate is implicated in epilepsy NLRP3 HMGB1 SLC25A5 PMC5354803__F5 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis COX2 SNAI1 RUNX3 SOCS3 PTEN RAF1 OGG1 IL1B NR1C1 STAT3 PMC6753173__F5 Schematic diagram of the pathogen-derived molecules used to escape cytokine-sensing pathways in cells STAT1 IFIT3 STAT2 IRF9 EIF2A TYK2 IFNAR2 JAK1 IFNAR1 PMC6753173__F4 A schematic diagram of pathogen-derived molecules used to escape intracellular DNA sensing pathways TBK1 CGAS DDX41 IRF3 AIM2 IFI16 PMC2777122__F2 Step 2: T-cell activation and costimulation APC HEL-S-92n PMC6397695__F2 IDO1-Kynurenine-AhR signaling in TME immunosuppression IDO1 AHR IFNG PMC4215179__F1 Protein trafficking of pericellular proteases MMP2 MMP9 PMC6514093__F3 Predicted arsenic resistance pathway in R HEL-S-62p MTR PMC7956936__F8 Mechanistic view of anthracycline-induced cardiotoxicity HEL-S-62p APAF1 C7 FADD PMC9242064__F2 Inflammatory bowel disease and cardiovascular diseases: a concise review TFPI F2 F5 PMC4303261__F6 Computational Approach to Identifying Gene-microRNA Modules in Cancer PLAUR CALB2 CTSK AQP1 ACTA2 MMP19 MMP11 VCAN ITGB1 COL16A1 THBS2 RECK FAP TIMP3 COL1A2 THBS1 COMP PDLIM3 EPYC INHBA MYLK PMC4303261__F5 Computational Approach to Identifying Gene-microRNA Modules in Cancer LOXL2 CTSK AEBP1 COL3A1 MMP19 MMP11 VCAN ADAM12 COL5A3 TDO2 GREM1 MMP2 THBS2 FAP COL6A1 DPT INHBA PMC9688668__F2 Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy TSC2 PI3 GRB2 PTEN TNF DEPTOR IRS1 RHEB PMC7766850__F8 Scheme of the effects of AMPAR antagonists on spontaneous seizure activity in epilepsy rats based on a previous and the present studies CDK5 SRC PTEN PMC3837137__F6 A diverse range of signaling pathways that can lead to persistent PKC activation to support cell migration EGF RFFL BRAF MYC LPA ARAF PMC8507231__F1 Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases ADA ADK PMC5359747__F1 Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction SRC ROBO4 ARHA RAC1 MYD88 ARF6 PMC3843239__F7 Mechanism of myosin II–mediated release of microparticles from endothelial cells activated by antiB2GPI antibodies IRAK1 TRAF6 IRAK4 RHO MYD88 PMC8307395__F3 Two-Pore Channels Regulate Expression of Various Receptors and Their Pathway-Related Proteins in Multiple Ways NFIB ROCK1 DAP3 CR2 HRAS CDC42 PMC8708574__F4 CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities CXCL13 BAD GSK3A SRC CXCR5 CDH2 DOCK2 PMC3148231__F12 MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus PTEN IRS1 CBL PMC3224437__F4 Fatty acid biosynthesis model and pathway distance calculation method PC FADS2 SCD FADS1 PMC3355926__F1 Activation of the Pi3K/Tor pathway by insulin and glutamate NF1 TSC2 TSC1 PTEN FMR1 PMC1899924__F8 Signaling pathways activated by mitogenic concentrations of TNFA and roles of furin, MT1-MMP, and MMP2 in the activation of the nSMase in mesenchymal cells MMP2 FURIN TNF PMC4837277__F1 Involvement of ROS in regulating M1 responsible phagocytic activity and inflammatory response IL18 TRAF6 ECSIT PMC6329517__F6 Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases TFEB MTOR TFAM PMC4993159__F2 Hepcidin Regulation in the Anemia of Inflammation HAMP IL6 STAT3 PMC6769473__F3 Genetic network and functions of PSGs (positively selected genes) related with the KEGG pathway of the PPAR signaling pathway, fat digestion and absorption, vitamin digestion and absorption PLB1 SLC27A4 PCK1 ADFP APOC3 MOGAT2 MTTP LRAT APOB GOT2 SCD RBP2 ACSL3 PMC4993159__F1 Hepcidin Regulation in the Anemia of Inflammation HAMP TMPRSS6 HFE IL6 STAT3 PMC10475367__F2 Kyoto Encyclopedia of Genes and Genomes pathway of target genes in CRC BAD BRAF SMAD2 APC GSK3B SMAD4 CASP3 MSH6 CASP9 CCND1 MSH3 MSH2 DCC CYCS AKT3 BAX PMC5709727__F7 TNF‐p100 pathway subverts noncanonical NF‐KB signaling in inflamed secondary lymphoid organs TRAF3 RELB TRAF2 LTBR PMC5115901__F10 Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury RASGRF1 PRG3 ARHA LPA PMC2758233__F2 P75NTR-mediated signal transduction pathways TRAF6 ARHA JUN PMC4340752__F1 UPR, autophagy and mitochondria crosstalk underlies the ER stress response ATG16L1 ATG12 ATG3 ATF4 ATG10 DKFZp686F0183 PMC7615304__F4 Germline and somatic mutations associated with primary aldosteronism GNA11 CACNA1H VAPA ATP1A1 MC2R KCNJ5 LHCGR CYP11B2 PMC2225459__F2 Schema illustrating the effects of (a) metformin- or AICAR-induced AMPK activation, (b)adiponectin, and (c) TZDs or PPAR alpha ligands on the rat granulosa cell steroidogenesis ADIPOR1 ADIPOR2 IGF1R IGF1 NR1C1 STAR PMC5706455__F4 Red Carpet for Iron Metabolism ERFE BMPR2 IL16 ACVR2A TMPRSS6 HFE IL6 TFRC IL6R TFR2 STAT3 PMC8924081__F4 G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN SRC GPR34 PTEN PMC2276852__F7 Schematic representation of the proposed events triggered by exposure to replication inhibitors such as APH BLM ATR PMC3110730__F1 Wnt signaling and regulation of Beta-catenin in tumorigenesis CREBBP APC CCND1 TCF4 PMC5403405__F7 Proposed mechanism for oridonin-induced G2/M arrest and apoptosis in prostate cancer cells MDM2 CDC2 BAX PMC7674641__F1 Metabolic pathways connected to protein prenylation HEL-S-26 ICMT RCE1 ARHA ACSS2 ACLY IPP HMGCR PMC6771146__F3A Pituitary Transcriptional Response Related to Feed Conversion in Pigs SETD1B MED12 CREBBP KMT2A SMARCA4 EP300 HCFC1 EP400 SETD1A NCOA6 MLL2 PMC10778733__F3 Visualization of CAC-related genes and their functional cross-talks ANKRD11 CCR2 IKBKG CHUK HDAC3 SLC5A1 GSK3B ORM1 NLRP3 PLAT TLR4 NGFR BIRC3 NOS2 SNCA SORT1 QPCT PLG AREG MMP9 NR3C1 ADRB2 TNF LTBP1 IKBKB SELPLG NTF3 NFKB1 RELA VTN MAP3K14 SELP GNAS PPARG SIRT1 MYLK STAT3 PMC4383151__F1 Metformin action to inhibit cancer STK11 SRC MTOR PMC3670858__F1 Acetylsalicylic acid metabolic pathway ACSM2B CYP2C9 SAG HEL-S-5 PMC10778733__F7 PPI is related to adipocytokine signaling ADRB2 NOS2 PPARG PMC12249733__F5 Involvement of the DEGs of NC and IC associated with effects of ACTH(6-9)PGP peptide a day after IR conditions in striatum PIK3CD GAD2 P2RY1 TNFRSF11A PENK CACNA1A MMP3 VAV3 PDE10A JUNB ATP2B4 IRF7 FOS UCN2 CYBB THBS4 SSTR2 GABBR2 LYPD6B GABRA5 CXCR4 AVP ABCA1 MAPK11 NCF1 OLR1 IKBKE CRHR2 SLC32A1 CALCR HAP1 LILRB4 KCNJ6 GDNF NR1A2 FGF22 SELE SCAP2 CAMK2D NTS MCU CD8A C3AR1 NMU CCK NFATC2 ADRA2A GRIK1 OXT SELP GABRA3 PMC5910405__F1 Our multi-omics integrative analysis of the monolignol biosynthetic pathway in P TH CCR2 POMT2 PMC9336020__F1 Myricetin: targeting signaling networks in cancer and its implication in chemotherapy HAMP MYC TRAF6 ARC MTOR STAT3 BAX PMC5897502__F1 Antigen receptor signaling in naïve and anergic B cells CSK LYN SYK PTEN PTPN22 PMC5819928__F1 EMT activation via TGFB TWIST2 SMAD2 VTN ZEB2 SMAD4 ARHA CDH2 PMC7685798__F7 Reanalysis of 14 designated genes via KEGG pathway enrichment CDK2 SMC3 MYC MDM2 ORC1L ORC3 CDK7 PCNA ORC2 SKP2 PMC5519084__F5 Activation of aromatase promoter I.4 and promoters I.3/II in breast adipose fibroblasts and promoter I.7 in breast endothelial cells PI3 ATF2 SF1 CREB1 CRTC2 SP1 STAT3 GATA2 PMC8137893__F1 Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma BRAF NRAS CCND1 CDK4 CDK6 PMC6650552__F6 AnvM-mediated regulation and its interaction with host cell TLR5 TRAF6 IL1B PMC6136787__F4 Newborn blood DNA epigenetic variations and signaling pathway genes associated with Tetralogy of Fallot (TOF) ME1 MEI1 PIR PMC9632414__F1 Editorial: Dissection of the molecular basis of fatty acid composition in oil crops and molecular breeding of oil crops with improved fatty acid composition SNRK DGAT2 LPA PMC4764103__F1 The CoA biosynthetic pathway PPCS PPCDC PMC6878783__F2 Astaxanthin improves insulin sensitivity and glucose uptake RAB14 RAC1 IRS1 RAB10 RAB13 PMC5102108__F7 Hypothetical model of macrophage-to-Huh7 cell transmission of TLR3-induced anti-HCV activity by exosomes DROSHA TLR3 PMC6789757__F5 Mitogen-activated protein kinase (MAPK) signaling pathway and related miRNAs CD14 NLK REN DAO MAX TRADD FLNA TRAF2 MPL MEA1 PMC3809754__F1 Biogenesis and function of microRNAs PAN2 DGCR8 EIF6 DROSHA CCR4 PMC10971110__F3 Immune response and gene expression through the NF-kB signaling pathway in sepsis TLR5 TLR7 TLR4 TLR9 LBP CD40 CD80 CCL2 MYD88 TLR1 TLR3 PMC4751587__F2 PI3K/AKT/mTOR signaling pathway and a proposed model for its regulation through the evaluated miRNAs TSC2 TSC1 ERBB2 ERBB3 PTEN EIF4E MTOR DEPTOR IRS1 RHEB PMC9289477__F1 Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers FYN APC LCK ZAP70 LAT PMC8514054__F1 JAK-STAT pathway mutations and variants in human disease STAT1 EPO STAT2 STAT4 TPO TYK2 JAK3 JAK1 STAT5B STAT3 PMC5818603__F1 Chromatin structure of human and mouse telomeres ZSCAN4 RIF1 SUV39H1 TET3 SETDB1 TPP1 DNMT3B POLD3 TET2 TET1 PMC9268676__F2 Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms IL10 IL13 IL6 IL4 PMC7387847__F10 Nrf2/SIKE-mediated hepatic injury induced by long-term PM2.5exposure TBK1 GCLM KEAP1 GCLC PMC7584080__F1 Pathway map highlighting all seven genes modified during this study in red TH MAEA CIT MAL PMC7162985__F1 AKT-mTOR signaling pathway TSC2 TSC1 DEPTOR RHEB PMC11700868__F1 Scheme of establishment and application of Nano-IFNG/Zole for remodeling the suppressive TIME induced by iRFA STAT1 TFEB IFNGR2 JAK1 NOS2 ARG1 IFNGR1 IPP IRF4 IFNG PMC4034063__F1 Core hypothalamic energy homeostatic circuit and the dopamine reward pathway POMC NPY AgRP MC4R ARC PMC3728801__F1 Canonical and non-canonical NFKB pathways INA RELA RELB PMC8809547__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis SLC25A32 PSAT1 SFXN1 PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC12003768__F5 Studying the efficacy of JBOL volatile components in idiopathic pulmonary fibrosis (IPF) using GC-MS and network pharmacology CCR5 CCR2 TLR9 AGTR1 ALK ALB FLT4 MAPK14 ALOX5 MMP3 MMP7 FGFR1 FLT1 NR1i1 GC SHH MAPK1 CMA1 NOS2 ABCB1 PTGIR GSTM1 LCN2 EDNRA IGF1 CYP2C9 PDE4B VCAM1 BCL2 TERT MPO REN RORB TNNC1 TOP2A ADAM17 MEN1 RBP4 CYP1A1 KIT CXCR1 PRSS1 PDGFRA BMP2 NR3C1 CFTR PTPN22 CTSG ENPP2 RNASE3 ERBB2 TYMS PPARG PLA2G2A PDE4A HMOX1 PRKCA MDM2 SRC ECE1 BMP1 PLG HRAS HMGCR HEL-S-22 TRPC6 VCP HTR2A MYLK CDC42 CHIT1 IGF1R F2R BRAF CTRC PDE5A EGFR NOX4 PLAT F2 F3 PTPN11 CCND1 IL2 ELANE XDH IL1B SELE NR1H4 NFE2L2 MMP9 PTGS2 S100A9 CYP2A6 CASP3 RPS6KB1 HEL111 MAP2K1 MMP12 CHRM3 NFKB1 PTPRO PIK3CA MAP3K8 RAF1 SCN5A MME STAT3 PMC4754612__F1 Stimulator of interferon genes (STING)‐mediated cytosolic DNA sensing pathway TBK1 CGAS AMFR DNASE2 DDX41 IRF3 PMC9693028__F3 Antioxidant Properties of Hemp Proteins: From Functional Food to Phytotherapy and Beyond KEAP1 IL1B PMC9901261__F1 Emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor SRC SYK ADAM10 ADAM17 PMC6618772__F1 Simplified metabolism of thiopurines in a target cell GPT TPMT TG PMC9656488__F2 DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex CHEK2 ATM RAD50 ATR CHEK1 MRE11A PMC8071014__F2 Glucose and lipid metabolism in TAMs MGLL ARG1 CD36 PMC7017203__F4 ING proteins are involved in the DNA Damage Response ING5 RNF8 ATM ING1 MDC1 MRE11A BRCA1 PMC4795487__F5 KEGG pathway analysis., The integrated pathway showing the interactions of differentially expressed proteins in apoptotic and survival pathways CASP3 CASP12 BAD TRADD ATM IL3 CASP9 TRAF2 FADD PMC8800112__F3 New blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort SNCA BATF2 SOCS3 SDC1 TRIM2 MMP9 ANXA3 APP UNK POR TNF BCL6 PMC8899158__F9 CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway ROCK2 MUC5AC IL4 PMC2577004__F1 Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-ALL MAML1 MAX MYC NOTCH1 PTEN MTOR FBXW7 HES1 PMC3085544__F1 Intracellular signaling by the leptin (LepRb - cyan) and insulin receptor (magenta) TSC2 TSC1 SOCS3 GRB2 STAT3 PMC8786676__F3 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation SPARC TNFSF10 MYC GRB2 CD44 BCL2 SELP CCL2 TNF BAX PMC8739787__F2 HIF-1A Is a Rational Target for Future Ovarian Cancer Therapies MMP2 SIK2 NPTX2 MMP9 VHL PFKL MTOR STAT3 BAX PMC11172598__F1 Gene interaction network map of each group KIN ALDH1A2 PMC9131029__F2 Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis GNPAT FAR1 PEDS1 GPD1 PEMT PMC12021866__F7 Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation DLL4 NOTCH1 SIRT1 HES1 PMC9360701__F2 Hypothesized neuroprotective effect of minocycline against COVID-19-induced stroke and neurological dysfunction: possible role of matrix metalloprotease signaling pathway MMP3 MMP14 MMP2 PLG MMP9 FURIN IL1B PMC6678131__F6 Role of LOXL3 in tumor SMC1A LOXL3 BRCA2 CCND1 HDAC2 RAD51 PKD1 MSH2 NUMA1 HDAC1 PMC2706143__F3 Endoplasmic Reticulum and the Unfolded Protein Response CASP3 CASP12 ATF4 CASP9 TRAF2 PMC4452354__F1 Schematic illustration of the transduction of signals from inflammatory bone diseases to brain-resident microglia through the leptomeninges and two different pathways for the IL-1B production activated by CGA and AB in microglia NLRP3 IL16 TLR4 CGA IL1B PMC4054417__F3 Distinct regulation of apoptosis pathway genes in neurons and fibroblasts in response to VZV infection NFKBIB BAG3 TRADD APAF1 BCL2 MYD88 MCL1 TRAF2 FADD CYCS NFKBIE PMC4817280__F2 Partial biosynthesis pathway for major brain gangliosides ST8SIA1 ST3GAL5 PMC2706143__F2 The Endoplasmic Reticulum and the Unfolded Protein Response ATF4 EIF2A XBP1 PMC3565264__F4A Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct MAX HP ATM BLM feat RRAS ATR RADIL NAPA PCNA PMC8786676__F6 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation CD44 SELP MCL1 PMC3017607__F2 The kinetic framework for programmed –1 ribosomal frameshifting EPO POR PMC5006677__F1 The Akt/mTORC1 signaling pathway leading to accelerated translation and increased protein synthesis TSC2 TSC1 IGF1 IRS1 RHEB PMC6101557__F1 Inflammatory caspases (caspase-1 and caspase-4/5/11) are activated through canonical or non-canonical inflammasomes, triggered by microorganism infection IL18 AIM2 IL1B PMC2374589__F1 Programmed cell death can be executed via extrinsic and intrinsic pathways depending on the stimulus leading to apoptosis DIABLO HTRA2 PMC7432699__F7 Schematic summary of the miR-targeting of RSU1 HEL-S-28 ATF2 PTEN RSU1 PMC8306961__F3 Arginine Signaling and Cancer Metabolism ELF2 MFN2 ATF4 ASNS GSK3B TEAD4 MTOR ELF4 PMC8306961__F2 Arginine Signaling and Cancer Metabolism GPRC6A SLC38A9 RHEB PMC7935942__F5 Expanding the drug discovery space with predicted metabolite–target interactions PLCB3 GPBAR1 IL17A PMC8306961__F6 Arginine Signaling and Cancer Metabolism BTK CCR2 BRAF TREM1 GSK3B MYC SYK CCL2 MTOR AXL ASS1 STAT3 PMC2578840__F8 Proposed signaling pathway SMAD2 SMAD4 PMC6637848__F9 L-proline-mediated differentiation of mESCs to EPL cells ATF4 EIF2A MTOR PMC6637848__F7 Cell signalling events that mediate the switch between self-renewal and differentiation in mouse embryonic stem cells FGF4 DUSP9 LIF GRB2 MTOR ID1 BMP4 STAT3 PMC3798256__F1 Pathways involved in stem cell hemostasis via regulation of nutrient sensing TSC2 TSC1 PTEN SIRT1 PMC3089033__F8 Diagram of the proposed cell survival signaling pathway in ER+ breast cancer cells with PI3KCA mutations and low phosphorylated Akt BAD FOXO3A FLII PMC6836728__F5 Schematic representation of the proposed intracellular trafficking pathways of NPRA through the multi-organelle systems in cell compartments: GC PMC5037386__F5 Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light AHRR AHR TRADD KEAP1 CYP1B1 CDKN1B EGFR SRC CYP1A1 ALDH3A1 CYP1A2 PMC2869518__F3 Proximal signaling events in the TCR-coupled signaling pathway LCK GRB2 LAT CDC42 PMC8329526__F2 Context-Dependent Roles of Claudins in Tumorigenesis EPCAM RUNX1 SMAD2 APC GSK3B MYC TAF9 SPX TYK2 PTEN BCL9 HES1 PMC5823598__F1 Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis RRAGD FLCN GHB2 PDK2 NRAS VPS18 PRKAA1 BYSL RPTOR DMD KDR RRAGB GCS1 FOXP2 UNK MAF1 VPS41 NGDN GPHN ATG12 PRKAA2 IGF2 MAPKAP1 RHEB PREX2 RICTOR RHOD RPS6KB1 STK38 GTF3C2 FBXO32 BIK TNS1 PLEK RRAGA MEFV CDC73 PMC7563273__F1 The activation and regulation of the PI3K/Akt/mTOR signaling pathway TSC1 PTEN EIF4E RPS6 DEPTOR IRS1 RHEB PMC3317163__F2 One-carbon metabolism HEL-S-61p AS3MT MTR PMC7563273__F3 Targeting the PI3K/Akt/mTOR pathway in AML TSC2 TSC1 PTEN EIF4E RPS6 IRS1 RHEB PMC9447342__F7 CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis MMP3 HGF PMC4712330__F3 PTEN tumor suppressor gene and its role in lymphoma pathogenesis TSC2 CENPC RAD51 PTEN MTOR RAN IRS1 RHEB NEDD4 MVP PMC4367908__F2 The network of molecules involved in the control of VPC fate determination and the cell cycle in C CDK2 APC CDK4 EFL1 CDC2 PMC4712330__F4 PTEN tumor suppressor gene and its role in lymphoma pathogenesis CARD11 BCL10 SYK PTEN MTOR CD19 PMC8909472__F2 Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance GRB2 CDK4 HRAS MTOR CDK6 PMC7684877__F6 Putative mechanism by which metabolite secretions of L MMP2 MMP9 VEGFA PMC7873381__F1 ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis APC GSK3B AXIN1 CSNK1A1 PPARG PMC11354764__F3 Three main UPR pathways induced by ER stress ATF4 EIF2A IRS1 PMC11354764__F2 Main pathways involved in the development of insulin resistance TSC2 GRB14 GRB2 PTEN MYD88 JUN IRS1 RHEB PMC11354764__F1 Insulin signaling pathway TSC2 BAD GRB2 CRK IRS1 RHEB CBL PMC12111366__F1 Hemp iron plays a role in muscle regeneration, lipid metabolism, and cholesterol management BMP6 HFE TFR2 PMC3885992__F5 Polarization of immune cells in the tumour environment by TGFB SMAD2 SMAD4 PMC8125586__F3 Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics CYP2R1 CYP3A4 CYP24A1 CYP27B1 PMC7815509__F1 Oligodendrocyte lineage cells and depression PC MOG PDGFRA MBP NOTCH1 BRD7 SOX10 OLIG2 PMC3757382__F1 Modified Fearson and Volgenstein Model BRAF APC SMAD4 PMC4529978__F1 ROS-dependent cellular senescence pathways in MSCs HMGA2 DNMT3B SIRT1 PMC3443885__F3 Molecular interaction between estrogen and thyroid hormone STAT1 SRC PMC3930904__F1 Global view on the intracellular proteome profile change in P AOX1 HEL-S-49 FBP1 ENO1 HEL60 HEL-S-32 HEL-S-68p PMC7143281__F4 Tricarboxylic acid (TCA) cycle showing differences in gene expression and metabolite abundances in mouse liver PDHA2 SDHC CS PDK2 DLD PDK4 IDH3B HEL-S-32 MDH2 PDK3 PDHA1 ACO2 SUCLA2 OGDH SUCLG2 PDHX SDHD DLAT SDHA SDHB PMC4595469__F7 Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells MICB EGFR MICA PMC7564814__F2 Intracellular cytoplasmic pattern-recognition receptor RIG-I is essential for the control of RNA virus infection STAT2 IRF7 IRF9 IRF3 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 STAT1 NLRP3 TYK2 MAVS PMC11696735__F5 Biosynthetic pathway of steroidal saponins in P DHCR7 EBP FDFT1 DHCR24 TM7SF2 PMC9203969__F1 NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches KEAP1 PMC4369322__F1 A model for the integral role of the Rad6 DNA damage tolerance pathway in coordinating the activities of Fanconi anemia (FA) network and homologous recombination repair (HRR) pathway in interstrand DNA crosslink (ICL) repair FANCD2 BRCA2 RAD51 FANCL RAD18 BRCA1 PCNA PMC3714590__F5 Known and Predicted Interactions between the Products of the 352 Genes Bound Preferentially by Pol II in Neuroepithelial CellsAnalysis was performed using STRING with a medium confidence score of 0.4 and all interaction methods available GOT2 MMP2 NOTUM EGFR RHO SHF TRAF4 PS1TP5BP1 GCM2 CCS PMC11950302__F8 Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer NCL BAX PMC2782644__F5 Differentiating Human Multipotent Mesenchymal Stromal Cells Regulate microRNAs AHR HCFC1 PDGFRA FOS NFKB1 MYC TGFB1 STAT3 CBL PMC11975384__F1 Comprehensive examination of the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 PMC5239825__F4 NRF2 as a hub connecting proteotoxic-derived emergency signals to a protective transcriptional response HEL-S-91n ULK1 GCLM PSMD5 ATG2B KEAP1 GCLC POMP PSMA4 PSMB2 PSMA2 GPX8 PSMB3 DKFZp686F0183 PSMD13 PSMB6 PSMD7 PSMD12 HEL-S-276 PSMD4 PSMD1 PSMC1 PSMD11 PMC7178451__EV1 STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer INA EPO TIMP1 GFAP VHL HEL-S-133P IFNG PMC6304530__F1 The reprogramming of metabolism in cancer IL16 MYC PTEN MTOR GLS PMC6982088__F1 Cyclic production of melatonin, from external (e.g., pineal and possibly extrapineal sources) or internal uterine sources, is responsible for promoting decidualization and improving implantation BMP6 IHH BMP2 LIF PTGS2 CYP11A1 HBEGF GDF10 AANAT BMP4 ASMT ERBB4 GDF15 STAR PMC3689263__F2 Signaling mechanisms important for endocrine resistance and which are currently targeted in clinical trials, combined with aromatase inhibitors EGF IGF1 SRC CDK4 PMC8619591__F1 Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis IRF9 IFNGR2 TYK2 IFNAR2 JAK1 MTOR IFNAR1 IFNGR1 IRF-1 PMC5339807__F4 Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling TH LEPR MME CLU HK2 PMC3353781__F8 Signaling pathways mediating Beta-adrenergic effects on the cardiac microtubule network PAK1 MAP4 PMC2911442__F5 WRN participates in the regulation of PCNA mono-ubiquitination and subsequent TLS through interaction with PCNA ATM RAD18 WRN PCNA PMC7372553__F9 CTNND1 function in systemic disease ARHA PMC7004516__F3 Association of efficacy of 5‐fluorouracil (5‐FU) and metabolic changes in cultured colorectal cancer cells ACACA DLD PFKM IDH3B HEL-S-32 MDH2 ACAT2 ACSL6 HEL-S-49 HEL-S-26 PC FH ENO2 SUCLG1 RPIA SUCLA2 ACLY PCK2 PFKP RPE DLAT HEL-S-281 SDHB PMC5541032__F3 Antibody-dependent enhancement (ADE) of Zika virus (ZIKV) and strategies to limit it IL10 STAT1 IL6 PMC6491625__F5 Network analysis of Ly6D, Ly6E, Ly6K, and Ly6H genes ALB CREB1 FOSL2 PAX3 CEBPB IFNG RARA RARB LY6E AHR BASH CD2 IL2 JUN LY6D CD3E FOSL1 LY6K FOS VEGFA TNF CD8A NR1C1 LY6H TEX101 HLA-C CD27 PMC4465499__F4 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications FGA RARA INS ACD HSF1 PMC4556940__F8 Network representation of microRNA CCR5 NOX4 PTGER3 PYGB AQP4 PTGS1 AGTRAP GABRB3 ACVR2A DBH NGFR SLC1A2 HEL-S-8a RGS1 JUN HEL-S-133P COQ7 PTGR1 CALCA FOSL1 RGS4 PTGS2 IL1RN NR3C1 GRIA3 FGFR3 NTS CD200 TNF GRIA2 LTB4R GAD1 PANX2 TNFRSF1B LTA GJA1 CRH TNFRSF1A HEL113 ACLY TGFB1 ACADM CCL3 PMC4465499__F3 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications FGA TH UBC HLA-A HP AEN APOE PMC8889667__F1 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia MYC CCND1 S100A9 PMC3100722__F1 The neuroendocrine (a), limbic (b), and brainstem (c) inter-related, stress-activated corticotropin releasing hormone (CRH) loops HEL-S-11 NTS CA3 PMC8266859__F8 Possible role of BA3/A1-crystallin in the EGFR signaling network and RPE polarity CRYBA1 EGFR RPE PMC8889667__F2 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia MUC1 TLR4 CD200 CCND2 PMC9687343__F5 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment COX2 PMC6561919__F7 ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation REV3L ATR PCNA PMC9687343__F4 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment LRP6 MTOR ACE2 PMC7078475__F1 Biochemical pathways involved in central carbon catabolism in P SUCO FBP1 MAEA ENO1 CIT TNLG7C SDHD SDHA MAL SDHB PMC8566972__F3 Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond TBK1 IRF7 IL2 PARP1 IRF3 CCL5 MTOR IRF-1 IFNG CCL3 PMC3733021__F1 Schematic diagram of the ZFN, TALEN, and CRISPR/Cas9 genome editing tools CSK APC BTLA TIGIT LAG3 DOK1 PMC8634046__F7 Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NFKB signaling IL6 TNF HDAC5 PMC3829921__F1 Small GTPases as regulators of cell division RAB21 RAB35 ARF6 PMC1904229__F12 Schematic model of Zfra/WOX1 involvement in TNF signaling TRADD TRAF2 FADD PMC6907041__F7 PBR-BuOH suppressed IgE/Ag-mediated allergic responses that are initiated by FcERI signaling pathway FYN GAB2 SYK PMC7694686__F1 Summary of MEMO1′s role in a variety of signaling pathways, including the: (A) ERBB-family, (B) FGFR-family, (C) IGF1R-family, (D) estrogen receptor and (E) PDGFR and S1P/S1PR families IGF1R APC GSK3B SRC ARHA CLASP2 PMC8533565__F1 Virus-Induced Tumorigenesis and IFN System CGAS TLR9 STAT2 IRF7 IRAK1 IFNE TRAF3 TRAF6 IRAK4 IRF3 MYD88 MTOR SLFN5 TLR3 CRKL STAT1 RET TLR7 TLR4 TYK2 JAK1 STAT3 PMC2764428__F4 MiRNA/TF-mediated regulatory pathway associated with tumorigenesis MYB TBP BACH2 HOXC8 MYC TFAP2A PAX3 E2F3 BCL6 STAT3 PMC9259489__F3 Intestinal epithelial cell mitochondria serve as metabolic signaling platform translating microbiome-derived signals into mucosal responses NLRP3 ATG16L1 LRRK2 HEL-S-67p IRGM TRAF6 ECSIT SLC22A5 NOD2 MAVS PPIF PMC2559887__F3 Ingenuity pathway analysis on NFKB related gene network HEL-S-166mP SPARC GADD45G CPT2 DBI ADORA2A GADD45B ZFP36 A2M TRAF5 DBP NDUFA13 LTBP2 NR1C2 THBS1 JUNB RPS6 PECAM1 PMC2559887__F2 Ingenuity pathway analysis on AP-1 related gene network GNE RHOT1 ARHGEF3 SPDEF IL6 KRT18 GIG8 ICAM3 KLK3 UNK JUND MCL1 BTG2 COX7C COX8A PMC3541122__F6 MiR-29 family is involved in multiple cellular processes STAT1 CDK6 PMC9277821__F2 Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance PIK3R1 NOTCH4 YAP1 APC VEGFA MYC VHL CD44 FOXO1 MAP4K1 KAT7 IGF2BP3 STUB1 KHSRP GC CNBP MAPK1 INHBA PMC5645395__F6 Illustration of the cooperative regulation of a miRNA module that contains four miRNAs: miR-18a-3p, -320a, -193b-3p, and -92b-3p (pink diamonds) PARVG RAPGEF1 BAD FLNA PAK4 ARHA TLN1 PTEN FLNB PIP5K1C HRAS PIK3R3 CRK SHC2 PRKCA PAK1 HEL-S-80p FYN LAMB1 CCND1 MAPK1 ACTN4 VAV2 PMC5645395__F5 MiRNA-mediated gene regulation involved in two functional pathways in the early stage of KIRC and KIRP (miRNAs: pink diamonds; genes: ellipses) CREBBP EP300 ATM NRAS MYC PTEN STAG2 PMC9607910__F1 Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer FGFR3 RB1 CDKN2A TERT PMC5693858__F10 A schematic of the mechanism of Panax notoginseng root (PNR) in its enhancing of antiviral interferon-mediated immune responses and natural killer (NK) cell activity TBK1 STAT1 IRF3 TYK2 JAK1 PMC4498560__F1 HPVs infect host epithelial cells (keratinocytes) by interacting with different cell surface receptors such as integrin and heparan sulfate proteoglycans (HSPGs) EGF EGFR MTOR PMC5966753__F7 Action of testosterone (T) in inducing hepatic steatosis/steatohepatitis DGAT1 CPT1A EIF2A TG TRAF2 XBP1 NR1C1 PMC4108232__F1 Mitochondrial dysfunctions in cancer HEL-S-62p CS FH PMC3583171__F3 Significantly differentially expressed genes identified by KEGG as involved in toll-like receptor signaling CD14 MAFK FADD TIRAP PMC9326066__F2 Single-Cell Metabolomics in Hematopoiesis and Hematological Malignancies HEL-S-26 ASNS LPL ASS1 HEL-S-133P HK2 CD36 GLS PMC5430701__F1 Chemokine signalling pathway (source-http://www.kegg.jp/kegg/kegg1.html) ITK DAO GRB2 SHE ARHA DOCK2 PMC7361144__F3 Type I interferon pathway during SARS‐CoV infection and modulatory mechanisms, PLpro excluded TBK1 STAT1 STAT2 IRF9 TRAF3 TRAF6 IRF3 JAK1 MAVS PMC3917856__F6 NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells GCLM EPHX1 GCLC FTH1 FTL HEL-S-107 UBB TXN ABCB6 AOX1 HEL-S-94n USP14 ATF4 GPX2 CCT7 HEL-75 PPIB VCP JUN CLPP PMC10258460__F1 Novel Metabolic Detour for Pancreatic Cancer Survival SRM KLF6 SMS PMC7774460__F2 RT induces local immunogenic effects CDA TNF IFNG PMC7748218__F6 Model showing contribution of CXCR6-CXCL16 axis in overcoming the effect of DTX: EGF CXCL16 BAD IMPACT GSK3B ADAM10 TGFB1 CXCR6 STAT3 PMC6288349__F7 Signaling in HIV-1-mediated inflammation NLRP3 CCR5 CXCR4 IL1B HLA-C PMC9213747__F2 Malignant Myeloid Leukemia by Mesenchymal Stem Cells ANGPT1 COX2 CXCL1 VCAM1 HEL-S-28 MSC IL8RB ARC CD74 AXL TGFB1 IL1B PMC9637482__F8 Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis MSC CD44 STAT3 PMC12124685__F11 HIV-1 infection stages, deregulated miRNAs, targeted hub genes, and principal enriched signaling pathways in macrophages MTOR PMC5979540__F7 Signalling pathways regulating pluripotency of stem cells regulated by detected differentially expressed miRNAs depend on muscle mass SOX2 APC INHA MSC TEF PMC5979540__F6 Hippo signalling pathway identified as the most regulated by detected differentially expressed miRNAs depends on muscle mass AFP AMOT AREG APC GSK3B TGFBR2 MYC AJUBA SCRIB WNT9A NID1 DLG4 NKD1 BMP4 PI3 DVL2 HEL-S-93 FRMD6 PMC6203874__F1 Cholesterol-dependent cytolysin FDPS FDFT1 GGPS1 HMGCR PMC4621609__F10 Schematic of a proposed model for GLP1-mediated signaling pathway protecting cardiomyocytes from PA-induced lipotoxicity BCL2 CD36 PMC5130051__F2 Engineered nanoparticles induce cell apoptosis: potential for cancer therapy FADD SIRT1 BAX PMC4747889__F3 Highest confidence network constructed with differentially methylated genes by proton beam treatment on the MCF-7 cell ERMAP SLC2A12 SUPT20H GTF2H4 CEP97 HMGCL GMFB RRAS ZW10 UBE2B YBX3 RSU1 HEL25 RPS10-NUDT3 NKIRAS2 RDM1 CASP8AP2 COMMD1 CENPA GTF2B PMC7847386__F1 Nucleic acid-sensing pathways and their evasion by SARS-CoV-2 during COVID-19 infection TBK1 CGAS IRF7 RIGI IRF3 MYD88 TLR3 GSDMD NLRP3 TLR8 TLR7 ENDOU ACE2 IL1B MAVS PMC12190939__F2 Roles of DDR1 in tumor immunology DDR1 CXCL5 SYK PMC8950262__F1 Tissue-Specific Expression of the Terpene Synthase Family Genes in Rosa chinensis and Effect of Abiotic Stress Conditions MVD MVK IPP PMC5948768__F12 ATP6AP2-induced neural differentiation GFAP GAL ATP6AP2 PMC7815874__F1 Increasing glycolysis by deletions of kcs1 and arg82 improved SAM production in Saccharomyces cerevisiae KL HEL-S-68p HEL-S-162eP PMC4654653__F2 Implications of microbiota and bile acid in liver injury and regeneration CYP27A1 GCA CYP8B1 AKR1D1 AKR1C4 CYP7B1 HSD3B7 PMC7695834__F8 Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway BMPR1A SMAD1 DKFZp781O1323 PMC4397621__F1 Schematic model of novel inhibitors in Fas-associated death domain-Procaspase 8 interaction and Caspase 3 activation via Caspase 8 TRADD TNF FADD PMC7441375__F9 Action of MPA GC PDE6A RHO PMC1779657__F2 Recent observations on the regulation of fetal metabolism by glucose TSC2 TSC1 EIF4E RHEB PMC5286961__F1 A scheme of the mutant p53–Nrf2–proteasome pathway with chemotherapeutic intervention targeted at mutant p53 and the proteasome BRAF KEAP1 PMC6556055__F10 Schematic diagram of mechanism on this research MAF KEAP1 IL1B NQO1 PMC6073315__F1 Schematic illustration of hypothalamic regulation of energy homeostasis POMC PC NPY CRH AgRP MC4R TRH ARC MTOR PMC9329830__F1 Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation SPARC BTC GDF15 DPP4 LCN2 RBP4 SPARCL1 UNG HEL-S-104 PMC3224806__F1 Deciphering the role of Th17 cells in human disease CXCL10 APC CXCL9 IFNG PMC6978354__F6 Differential methylation of genes in the B-cell receptor signalling pathway IKBKG CHUK PPP3CA DAO PLCG2 IFITM1 DAPP1 BTK BASH PTPN6 CD19 SOS2 FOS MAP2K2 RAC1 HRAS CD79A IKBKB NFKBIA CD72 PRKCB NFKB1 CD22 LYN GRB2 PIK3CA SYK CR2 VAV2 PMC7855922__F1 PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective CSH2 BRAF PTEN MTOR PMC6139279__F1 ROS signaling and ER stress in cardiovascular disease ATF4 EIF2A XBP1 PMC6330712__F3 Simplified pathway for the synthesis of the GPI-core (based on Cardoso et al., ) DPM1 PIGH DPM2 PMC12245687__F6 Mechanism of the Wnt signaling pathway APC LRP5 LRP6 PMC8867516__F1 Rare Autoinflammatory Diseases TBK1 STAT1 CGAS STAT2 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 PMC12245687__F8 Schematic diagram summarizing the mechanisms of intestinal signaling pathways ROCK2 NLRP3 TLR4 TLR9 ROCK1 TRAF6 ARHA RHO MYD88 MTOR GSDMD PMC12245687__F7 Mechanism of the Nrf2 signaling pathway HMGB1 NR1i1 KEAP1 PMC12245687__F4 Mechanism of Rho/Rock signaling pathway ROCK1 ARHA RHO PMC6073797__F9 Mechanisms underlying the effects of Stachys sieboldii (SS) NGF BDNF BAX PMC12245687__F3 Signaling pathway mechanism of TLRs TLR4 TLR9 TRAF6 MYD88 PMC8714987__F8 Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension PIEZO1 NOTCH1 NOTCH3 PMC3246295__F2 Gab2 interactions with binding partners GRB2 TPO RAF1 PMC5411014__F3 Pathophysiology and management of CVD HEL-S-62p VCAM1 C6 PMC5228698__F1 Diagram of genes in the PI3K/AKT signaling pathway MYB EPOR FLT4 GSK3B IL6R FGFR2 OSMR FLT1 LAMB4 KDR APIP CASP9 ITGA2B SOS2 FGF16 GNGT2 THBS4 IRS1 RHEB LPAR4 MLST8 TSC2 TSC1 IGF1 CDKN1A PKN2 IL2RG STK11 BCL2 IL2RA FGF14 GNB1 FGF4 GHB2 LPAR2 PPP2R1A GNGT1 COL1A1 FGF20 FGF9 TLR4 PDGFA opn KITLG VWF FGF22 YWHAG RBL2 CD19 FGF7 KIT RAC1 IFNB1 GNG12 HEL-S-125m IL3 COL4A2 PHLPP1 IL3RA IFNA21 GNB2 PPP2R2C PRKAA1 TNFSF6 PIK3AP1 FGF3 COL9A2 FGF10 MDM2 COL6A1 PPP2R3C CDKN1B G6PC1 IFNAR2 EIF4E IFNAR1 EFNA5 CDK2 ITGA6 GRB2 COMP HSP90AB1 INS GNG10 RPTOR INSR IFNA5 IFNA7 IFNA6 IFNA8 FGF23 IFNA13 IFNA14 ATF4 IFNA16 IFNA10 COL1A2 CCND1 GNG11 CDK4 COL9A1 RPS6 XB COL4A4 FGFR3 GYS1 PPP2R1B RPS6KB1 LAMB1 EFNA4 PKN3 MCL1 GHB3 EPO MYC GNG7 CDK6 CCNE1 CSF1R FGFR1 ANGPT4 IL7R GHR IFNA2 CHRM2 ANGPT2 RELN FGF13 FGF12 GYS2 YWHAQ PPP2R3B PPP2R5C GH1 IFNA17 FGF21 CSH2 PHLPP2 PCK1 KPG_010 LPAR1 CCND3 EFNA2 EIF4E1B CCND2 THBS1 IL4 ATF6B PPP2R2A LAMA5 IL2RB CCNE2 PPP2R3A ITGA1 PPP2R2D GNG5 PDGFRA PPP2R5A CDC37 FGF18 ANGPT1 IL7 SYK CRTC2 EPHA2 OSM CSF1 NGF EFNA1 FGF8 FGFR4 BCL2L1 EFNA3 PDPK1 ITGA2 PRKCA FGF19 PCK2 COL2A1 LAMC2 LAMB3 LAMB2 BRCA1 LAMA3 GNG3 RXRA GNG8 TNC LAMA1 THBS2 THBS3 CHRM1 VTN IBSP CHAD TNR ITGAV PPP2R5B LAMC1 PPP2R5D GNB4 EGF BAD GNG13 HGF F2R IFNA4 HEL2 GNB5 CSF3 ITGA7 PTEN ITGA4 BCL2L11 MTOR PDGFD GNB3 GNG4 NGFR GNG2 IL2 TCL1B COL6A6 PRKAA2 FGF2 FGF6 PKN1 PRL PPP2R2B PDGFC PRLR PPP2R5E SOS1 HEL-S-93 PMC5618562__F2 Interplay between G-Protein Coupled Receptors (GPCR) signaling regulated by melatonin and GPCR signaling regulating YAP/TAZ TBX5 LATS1 RHO PMC4583820__F1 Involvement of IAP proteins and IAP antagonists in the apoptosis and NFKB pathways [, ] RIPK1 TRADD TRAF3 RELB TRAF2 FADD PMC5514949__F7 Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway SMAD2 SMAD4 PMC11685696__F4 Intestinal microbiota mediate CID through the TLR receptor and cGAS-STING pathway TBK1 CGAS TLR9 IRF7 TRAF6 IRAK4 IRF3 IL6 MYD88 TNF TLR3 TLR8 LTA TLR7 TLR4 PMC5618562__F4 Interplay between melatonin signaling, cell contact-cell polarity complexes, mechanotransduction, and YAP/TAZ TBX5 ARHA NOS1AP LATS1 RAC1 PMC11685696__F3 Mechanism by which intestinal microbiota regulates intestinal mucosal injury through STING pathways TBK1 CGAS IRF3 PMC5618562__F3 Interplay between melatonin, YAP/TAZ, and metabolic pathways IRS4 TBX5 MTOR IRS1 PMC4791395__F3 Stealth strategies of Brucella TLR4 ELL PMC4890468__F2 The mammalian target of rapamycin (mTOR) signaling pathway and crosstalk with the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway NF1 TSC2 TSC1 EGFR MYC PHLDA3 PTEN IRS1 PMC4791395__F2 Strategies of Brucella to evade the innate and adaptive immunity TLR4 TLR9 MYD88 TIRAP MAL PMC8650121__F1 Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol HEL-S-11 TRPC6 TRPC3 MLSN2 TRPM7 PMC1899380__F1 Late steps in corrin ring biosynthesis in serovar Typhimurium ADA APP NDP PMC6493983__F1 Pathways to cellular senescence in eukaryotic cells ATM ACTA2 CDK2 CDK4 ATR CDK6 COL4A1 PMC10384366__F1 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells SUFU GSK3B HEL-75 SMO PMC8391142__F3 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers SOX2 CHL1 EIF5A MTOR STAT3 TET1 BRD4 PMC3879068__F3 Networks showing metabolic pathways differentially modulated between H and L groups ITPR2 ACACA RGS4 CTSF ACSS2 ELOVL6 BNIP2 THRSP MPZ APOB AHSA1 HP RASGRP3 SCD B3GAT1 FASN PMC8391142__F2 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers IL1B PMC4576950__F2 Processing of the Notch signaling pathway and the nuclear cycle HES5 NOTCH1 SPEN FURIN CDK8 HES1 PMC8391142__F1 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers CYR61 SOX2 ABCC1 CD44 NOTCH1 SMO ABCG2 SKI SOX9 CD24 PMC9179862__F9 CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis ACKR3 CXCR4 CXCL12 PMC3756614__F11 Signaling pathways used by EGF to stimulate goblet cell proliferation EGF EGFR GRB2 SRC PMC3099575__F5 Model of relationship among Hfe, Tmprss6, and the Bmp/Smad signaling pathway in hepcidin regulation BMP6 HAMP TMPRSS6 HFE ID1 PMC3088084__F4 Therapeutic effects can be monitored using DMR on scant cell populations EGFR GRB2 MTOR PMC8915145__F3 Common pathways control autoimmune susceptibility and TFH cell homeostasis TH LRBA CXCR5 CTLA4 ICOS PMC6109707__F8 Complement activation and involvement during alcoholic liver disease HEL-S-62p C4B_2 TNF PMC9658582__F5 Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis TH SNCA CAST MCU WAS POR PMC3499881__F1 Regulation of the polyamines putrescine, spermidine and spermine by biosynthetic enzymes (shown in green) and catabolic enzymes (shown in red) SMOX SRM PAOX SLC3A2 AMD1 SMS HEL-S-18 PMC8749860__F1 BRCA1 and Metastasis: Outcome of Defective DNA Repair PALB2 ATM BRCA2 RAD51 BRCA1 PMC6932941__F3 Diagram of the pathways involved in the metabolic interaction of glycolysis, mitochondrial respiration, and hyaluronan synthesis PDC OGT CIC CD44 PMC3892099__F8 Summary of parthenolide-induced signaling pathway in NSCLC cell lines ATF4 PMAIP1 EIF2A TNFRSF10B DDIT3 PMC8117419__F2 Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy GPX4 PMC11983172__F11 Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study TLR4 IL6 GPR18 PMC2939232__F10 Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2) EEF2K EEF2 MTOR PMC4033012__F2 Schematic representation of the NALCN channelosome NALCN UNC80 CASR UNC79 PMC9354910__F3 Common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19 HLA-A LEP CXCL16 AHR F2 CXCL10 INS TYK2 CXCL2 MTOR HLA-B HLA-C PMC9252571__F1 Metabolic pathways implicated in ferroptosis GPX4 STEAP3 KEAP1 IBRDC1 TF SLC39A14 PMC6766640__F3 Convergence of the TGFB and collateral signaling pathways regulates transcription of the profibrotic PAI-1 and CTGF genes AFP PATJ SOX2 GIG8 AMOT AZIN2 AREG APC MYC LATS1 RASSF6 LATS2 PMC3666170__F3 Role of Cx43 and Panx1 hemichannels in paracrine signaling in taste transduction PLCB2 TRPM5 PANX1 PMC3046528__F6 Monosodium urate (MSU)-mediated inflammation and the roles of spleen tyrosine kinase (Syk) and Nlrp3 CARD9 IL16 SYK PMC7690394__F1 Folic acid metabolism and 5-MTHF transport across the choroid plexus epithelium in the brain DHFR MTHFS PMC6647482__F3 The interplay between purinergic signaling and ComC activation during sterile brain inflammation HMGB1 S100A9 PMC9146749__F7 Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells STAT1 JAK1 PMC3351347__F7 Control of Pax3 expression in the caudal neurectoderm via NCE2 SHH PAX3 TEAD2 PMC6678794__F1 Delta-like ligand 4 (DLL4) and Jagged1 exert different effects on Th subsets differentiation TH DLL4 APC PMC115962__F5 IFNG signaling pathway showing the defects in the human fibroblast mutants B3, B9, and B10 STAT1 JAK1 IFNG PMC6261508__F1 MTOR pathway in treatment of epilepsy: a clinical update TSC2 NPRL2 RICTOR TSC1 C16orf35 DEPDC5 PTEN EIF4E MTOR STRADA RHEB PMC3503525__F1 WNTS AND TGFB IN SYNAPTOGENESIS: OLD FRIENDS SIGNALLING AT NEW PLACES MAP1B APC GSK3B SMAD4 PMC6079151__F4 WNT pathway promoting endometrial carcinogenesis APC GSK3B PMC7600741__F3 Ca2+-signaling pathways and HCC cell apoptosis MCU ORAI1 STIM1 PMC9259665__F2 Trends in insulin resistance: insights into mechanisms and therapeutic strategy TSC2 PDE3B TSC1 PCK1 ABHD15 GCK ACLY FOXO1 PMC2712099__F2 The aryl hydrocarbon receptor (AHR) signalling pathway AHRR AHR PMC10984988__F9 Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells CSF3 IRAK2 BIRC3 CCL20 LCN2 RELB NFKBIZ SAA1 TNF CSF1 PMC8727603__F2 Rotavirus Interactions With Host Intestinal Epithelial Cells STAT1 STAT2 IRF9 CXCL10 IRF3 TLR3 MAVS MX1 PMC5746415__F1 Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade CXCL8 BTLA CCL7 CCL5 PTEN LAG3 B2M FOXP3 PMC9058838__F4 Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway ChAT PIG59 HEL-S-30 PCK1 CDS2 ENO1 ACHE HEL-S-87p LPCAT1 PYGM HEL-S-68p HEL-S-162eP ADSL GPT2 CHPT1 AGXT CHKB CAD CRLS1 ASS1 PGAM1 HK2 ASL GLS PMC3471948__F4 Cross-Species Genome Wide Expression Analysis during Pluripotent Cell Determination in Mouse and Rat Preimplantation Embryos ROCK2 PIK3R1 NFKBIA GSK3B MYC RALA CCND1 PIK3R3 MYLK3 SKP2 MYLK CCNE1 PMC4285772__F7 SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model SOCS3 RELA PTEN STAT3 PMC3916724__F1 Molybdenum metabolism in higher plant cells FES XDH PMC4810800__F2 TGFB1/SMAD signaling pathways in hepatic fibrosis SMAD2 SMAD4 BMP7 SMAD1 DKFZp781O1323 PMC12136530__F8 Proposed mechanism by which arginine inhibits tumor growth OTC CAD ASS1 ASL PMC3594520__F1 TLR3 immunity to infection in mice and humans TBK1 TRIL TANK TRADD TRIM21 TRAF3 DDX3X IRF3 ELMOD2 TLR3 PMC2752832__F7 Scheme for up-regulation of the PAI-1 gene by EGF in glioblastoma EGF ATF2 EGFR SRC SPHK1 CDCP1 PMC6204952__F4 GC-C activation, intracellular effects IL1B CFTR IFNG PMC5800892__F7 TRAF-STOP Treatment Reduces Atherosclerosis and Preserves ImmunityBinding of CD40L to CD40 results in the recruitment of tumor necrosis factor receptor-associated factors (TRAFs), and propagation of signaling TRAF6 CD40 CD80 ELL PMC7014934__F1 An overview of autophagy machinery ATG12 ATG101 DKFZp686F0183 PMC3969300__F1 Establishment of left/right (LR) asymmetry during development ACVR2B NODAL CFC1B PMC9455056__F4 MYCN and Metabolic Reprogramming in Neuroblastoma PFAS OMP ADSL UMPS PAICS HEL-S-70p CAD DHODH PMC4801062__F3 ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis EGF PDGFA PDF PMC9455056__F3 MYCN and Metabolic Reprogramming in Neuroblastoma PSAT1 PSPH MTHFD1 MTHFD2 PHGDH PMC9655262__F4 Necroptosis: A Pathogenic Negotiator in Human Diseases RIPK1 RIPK3 MLKL PMC11024365__F9 Proposed modeling of antioxidant mechanisms in H MYB CAD PRX PMC8658611__F5 Impact of Cigarette Smoking on the Expression of Oxidative Stress-Related Genes in Cumulus Cells Retrieved from Healthy Women Undergoing IVF KEAP1 USP14 GCLC FTH1 GPX2 GSK3B CCT7 FTL HEL-75 HEL-S-107 PROX1 UBB PMC9455056__F1 MYCN and Metabolic Reprogramming in Neuroblastoma PHGDH HK2 PMC9124882__F2 Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands TLR7 TLR4 TLR9 IRF7 TRAF6 IRF3 IL6 MYD88 TLR3 PMC6881706__F1 Circular RNAs Regulate Cancer Onset and Progression via Wnt/Beta-Catenin Signaling Pathway APC CCND1 DKK1 APC2 BCL9 PMC6348061__F2 Simplified diagram of the acetylcholine (ACh)-signaling pathway in human lung cells ChAT ACHE BCHE PMC6540157__F1 RNA granules and caprin-1-associated tumorigenesis AGO2 CD47 DCP2 EIF2A MYC CAPRIN1 PMC6287147__F8 Schematic illustration of a working model for the TGFB1/SMAD/Snail pathway in modulation of EMT-dependent fibrosis in SGEC SMAD2 SMAD4 PMC10380572__F2 Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients BTK LYN GRB2 LAT PMC7729937__F11 Proposed mechanism of the differential actions of arecoline on cell growth among RWPE-1 (A), PC-3 (B), and LNCaP (C) cells CCNB1 CCND1 CDK4 CDC2 CCND3 PMC8117014__F4 Research Progress of circRNAs in Head and Neck Cancers EGF APAF1 CRIM1 EGFR FOXQ1 PTEN ATRNL1 PMC3961947__F1 Molecular pathways altered by green tea extract MAP2 IGF1 BCL2 PMC6065049__F6 PKC pathway for prolactin regulation of the metabolic genes for citrate-producing prostate cells FOS JUN PRL PMC4689760__F1 Cholesterol biosynthesis pathway is altered in CEM/R2 cells SQLE SOAT2 EBP SC5D DHCR24 IDI1 HMGCS1 HSD17B7 TM7SF2 IPP CYP51A1 HMGCR LIPA DHCR7 FDFT1 SOAT1 ABCA1 MSMO1 PMC6435069__F2 Complement regulators HEL-S-62p C9 CS CD46 C4B_2 C7 C4A PMC6435069__F1 Complement pathways HEL-S-62p CS C4B_2 C7 C4A PMC6609813__F2 Suppressive mechanism of regulatory T (Treg) cells PDC APC CD80 LAG3 ICOS FOXP3 PMC7993742__F3 Protein-protein interaction (PPI) of differentially expressed aging-related genes P2RY1 GGH CCNA2 CTSS FBLN2 PLK1 NPM1 POSTN MMP11 IRAK2 MYC CENPF CXCL8 CCL5 FGFR4 FGFR2 ITGA2 MMP3 MMP7 DCN RPL12 A2M RPS19 CCL13 C7 MSX2 B2M HEL-S-281 QPCT CKS2 CALU RPL35 VEGFA LCN2 RPN2 RPL18 CENPE CDC25B AURKB APOB RPL22L1 CDC20 SNRPD2 THBS2 LDHD CDKN2B ITGA6 HEL-S-100n MYLK PCNA CD36 TUBA4A TPM1 COL3A1 MYL6 TFRC HEL-S-128m CLU CCND2 BMP4 CXCL16 opn GZMA CCL28 ETS2 RPS6 CNN2 CHI3L1 MYBL2 FBL CBX3 HEL-S-79 BMP7 CXCL2 SERPINE2 RHOD UBE2C MMP12 ADRA2A PLOD3 DPT PMC9569594__F10 Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism B4GALNT1 GAL PMC4219530__F1 Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation CXCL1 CHUK IKBKG NLRC4 MAPK10 MAPK3 TRAF6 CARD6 CCL2 RIPK2 TNF MAP3K7IP1 NOD2 PSTPIP1 IKBKB NLRP3 CARD9 NOD1 BIRC3 MEFV PYCARD CASP8 IL1B PYDC1 PMC4250958__F1 Differential Apoptosis in Mucosal and Dermal Wound Healing CASP3 CASP6 TRADD CASP9 CASP2 CASP8 CYCS PMC4086428__F4 Predicted network linking pancreatic cancer miRNA markers, known pancreatic cancer genetic lesions, and DAMPs HMGB1 BRCA2 ZEB2 SMAD4 BCL2 S100B BRCA1 PMC4086428__F3 Three commonly differentially expression MicroRNAs in pancreatic cancer tissue and patient blood: MicroRNAs 21, 155, and 200 TP53INP1 BRAF RECK ZEB2 PTEN MYD88 SOCS1 PMC11652788__F5 TsRNA in neurodegenerative diseases CLP1 NSUN2 PMC6723754__F3 Signaling pathways elicited by stabilin-mediated phagocytosis of apoptotic cells GULP1 DOCK1 RAC1 CRK PMC7669705__F2 Opportunities for combination therapy NF1 PLK1 CCNB1 CCND1 CDK4 PTEN CDC2 RB1 MTOR AURKA PMC8038661__F2 Extracellular regulators of adipogenesis WNT3A BMP2 GC GLI3 SMAD4 SHH NOTCH1 MTOR SMAD1 GATA3 GATA2 FOXA2 PMC7599682__F2 SRC structure and regulation VTN EGFR MTOR STAT3 PMC10533267__F7 sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway TBK1 TRAF3 TRAF6 IRF3 TNF PMC4835424__F1 Plausible biosynthetic pathway leading to atisine in A PDC PGP MVK IPP HEL-S-162eP PMC5139139__F4 Linking identical processes found between two metabolic maps COPE IFNGR2 ENG IRF-1 ASL IFNG PMC5739856__F1 Neutrophils promote tumour growth through direct and indirect mechanisms CCL17 ARG1 PMC2924908__F2 Complement - a key system for immune surveillance and homeostasis VTN APC CRP PMC10474740__F2 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization IGF1R MMRN2 IGF1 SMAD2 IGFBP7 GRB2 SRC HBEGF CD93 IRS1 FOXO1 PMC2729336__F3 Transcriptional control of HC and amacrine cell development BARHL2 PTF1A FOXN4 SIX3 NEUROD1 PROX1 ISL1 PMC10474740__F3 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization MMRN2 IGFBP7 SRC ARHA RAC1 RAB5C CD93 CRK CDC42 PMC10452661__F2 Crosstalk between IL-6 signaling and the PI3K/AKT/mTOR pathway in EAOC PTEN MTOR ARID1A PMC10452661__F1 PI3K/AKT/mTOR pathway-related gene alterations involved in the pathogenesis of Endometriosis and Endometriosis-Associated Ovarian Cancer PIK3R1 ERBB2 PIK3CA PTEN ARID1A PMC11947373__F1 COVID-19-induced molecular mechanisms that propel OSCC development and chemoresistance NLRP3 NRP1 MTOR ACE2 PMC5096733__F1 Simplified diagram of mTORC1 and ERK1/2 signaling following muscle contraction EEF2K EEF2 RPS6 PMC8046170__F3 Human complement cascades C9 C4B_2 CLK1 VTN CRP C7 C6 C1S C4A PMC7882174__F2 Role of leonurine in cardiovascular disease BAD MTOR CP PMC7779461__F5 Chemokine Signaling Pathway Based on DAVID Analysis of KEGG Pathway Database BAD DAO GRB2 ARHA DOCK2 PMC8351522__F2 Biomarkers and targets of mitochondrial dynamics TBK1 APC AMBRA1 OMA1 HUWE1 PINK1 CDC2 INF2 PGAM5 PHB2 PARL OPA1 BAX PMC8351522__F5 Biomarkers and targets of mitochondrial dynamics NLRP3 YAP1 DGUOK HEL-S-51e AIM2 IFNG PMC8351522__F4 Biomarkers and targets of mitochondrial dynamics ND6 C1QBP MDM2 PAH METTL4 PMC10865418__F5 Schematic diagram illustrating the hypothesis of signaling regulation in aGVHD MTOR FOXP3 PMC8351522__F1 Biomarkers and targets of mitochondrial dynamics MFN1 MFF APC OMA1 HUWE1 SPIRE1 PINK1 MFN2 CDC2 INF2 PARL AIM2 OPA1 BAX PMC3136902__F1 IL-1RI signaling IRAK1 SIGIRR IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 JUN IL1B PMC3531074__F3 Network exploration options HEL111 UTY TES PMC6290135__F1 Polyamine biosynthetic pathway in single-celled parasitic eukaryotes EIF5A HEL-S-64p DAP DOHH TG CP PMC7254625__F1 Pathogenesis of non-hereditary brain arteriovenous malformation and therapeutic implications BRAF HRAS MTOR EPHB4 PMC8928114__F4 Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics IL21R TRADD IL7R TYK2 JAK3 JAK1 TNF IL23R TRAF2 STAT3 PMC3355968__F2 Regulation of Mcl-1 and Snail by AKT, ERK, and IKK signaling pathway PIN1 GSK3B CSN2 PMC3355968__F1 Regulation of FOXO3 and Beta-catenin by AKT, ERK, and IKK signaling pathway FOXO3A MDM2 SKP2 PMC6433688__F11 Illustration of the FGF16 signalling pathway to regulate Leydig cell development FGF16 PMC2822851__F1 Signal transduction pathway from integrin receptors to actin cytoskeleton ANK2 VASP MARCKS FLNA ACTA2 HEL-S-15 EZR WAS RHO CRKL DMD FYN VAV3 DIAPH2 DOCK4 SRC HEL114 RHOB KIT ACTG2 WASF1 VAV1 ARHA DOCK1 RAC1 CRK SPTA1 PS1TP5BP1 TIAM1 RAC3 WASL LCK LYN WIPF2 DOCK3 DOCK2 CDC42 VAV2 PMC8693951__F1 TLR7 signaling in lupus B cells TLR9 IRF7 IRAK1 UNC93B1 TRAF6 IRAK4 MYD88 TASL IFNG STAT1 TLR7 BCR BANK1 SLC15A4 PMC4792934__F10 Proposed store-operated signaling mechanisms in end-feet of Müller glia TRPC1 NACA STIM1 PMC3857640__F5 Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk JAK3 STAT3 PMC6479272__F13 Partly hypothetical model describing the characteristic shifts of balance within the sphingomyelin/salvage pathway attributed to immune low and immune high tumor subtypes/subgroups of patients SGPP1 SMPD2 LPAR2 KPG_010 LPA LPAR1 SPHK2 LPAR3 CD163 CERS3 LASS1 CERS5 CERK CD68 CERS2 CD14 NAAA S1PR1 SGMS1 ENPP2 SMPD1 SPHK1 SGMS2 CERS6 SGPP2 PMC6880815__F3 Putative biosynthetic pathway to the nanangenines F10 F11 PMC9578081__F5 11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease HSD11B2 CRH CYP11A1 HSD3B2 CYP17A1 CYP21A2 STAR CYP11B2 PMC7339600__F5 Protein-protein interaction network for the DEGs in the brown, blue and red modules UNC13C EGFR CA14 SLC32A1 PROC LXN PFKM ATP6V1C2 BCAS2 HEL-S-32 CADM2 CD109 HEL-S-108 AMFR MCAM KDR CARNS1 CCL13 EPHX2 GNG11 CYP1A1 NRAP GJB1 HEL-S-117 PGAM2 TMEM163 KIT FBP2 MYOM3 DENND2C SLC25A5 HEL-S-30 VCX2 SLC18B1 FGF6 SMTNL1 TUBB1 MSTN LAMA4 CD79A NID2 MYLK2 NRP1 FHL2 PIAS1 CKMT2 CD93 MYLK4 PMC4314775__F7 Proposed mechanism of differential regulations of NFKB – miR-29b – p53 pathway by S100A7 in different types of breast cancer cells YY1 S100A7 CDC42 PMC5056381__F8 The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus GSK3B TCF7L2 GIP PMC7339600__F6 miRNA-TF-target regulatory network KIT FGF6 NRP1 VEGFA CYP1A1 CKMT2 NR1C1 HEL-S-32 COL4A2 COL4A1 PMC6412338__F3 mTOR signaling network TSC2 EEF2K ULK1 TSC1 FOXO3A F3 PTEN DEPTOR SGK1 FOXO1 RHEB PMC10916191__F8 Working model of lipid synthesis induces by PPAR and cell cycle regulation in GCs after MLN4924 treatment EBP CCND1 BCL2 CDK4 ACSS2 PCNA CDK6 FASN BAX CD36 PMC5308742__F8 De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells NAMPT HEL-S-90n SIRT1 FOXO1 BCL6 PMC6883191__F2 Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs STAT1 CD14 TLR4 LBP TRAF6 LY96 MYD88 IFNG PMC3843070__F5 Model illustrating the potential role of CRKL in recruiting NleH1 to inhibit RPS3/NFKB signaling during A/E pathogen infection RPS3 TNF MAP3K7IP1 CRKL PMC10898168__S1 Inhalable hybrid nanovaccines (NVRBD-MLipo) with virus-biomimetic structure against SARS-CoV-2 infection TLR4 CD80 TNF PMC11554530__F2 Functional plasticity of Tregs and Th17 cells IL10 IDO1 PTEN TIGIT STAT3 FOXP3 PMC6685593__F10 Piezo1 promotes tumorigenesis of prostate cancer PIEZO1 CCND1 CDK4 MTOR PMC8146082__F2 Unfolded Protein Response: An Overview ATF4 EIF2A ATF3 PMC3023029__F2 Intracellular transport pathway of Shiga toxin EHD3 RAB33B RAB43 YKT6 SNX8 VAMP3 ARL1 SNX2 SYK ARHGAP21 VTI1A CDC42 SNX1 PMC7586431__F5 Statin therapy for cancer CASP3 ARHA MTOR TF PMC7586431__F3 Statin therapy for coronary heart disease MCM6 CDK2 ARHA MCM7 RAC1 PMC6966530__F11 Effect of tyrosine phosphorylation of PDHK1 and PKM2 on the fates of pyruvate and acetyl-CoA in normal and cancer cells (modified according to ) PDC GRB2 ACLY HEL-S-133P FASN PMC3742712__F2 Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection NLRP3 NLRC4 AIM2 IL1B PMC6332483__F6 Schematic model of SNHG6 in CRC cells PMC5907676__F1 Wnt signaling pathway PI3 APC ARHA SOSTDC1 WIF1 PMC6269119__F1 The activation of an intracellular channel promotes the trafficking and secretion of a cytokine TLR4 CCL2 PMC8263212__F1 Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad STAT1 APC ARG1 STAT3 PMC3109490__F1 Francisella tularensis tularensis targets the PI3K/Akt pathway at multiple levels PTEN PMC11524448__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages SCAP2 NLRP3 c-fgr LYN SYK STIM1 PMC6963649__F2 Simplified schematic diagram showing synergistic and antagonistic interactions between the ABA signaling pathway and other hormonal signaling pathways during abiotic and biotic stress MYB MYC ERF PMC3766375__F2 Fat side of Prostate Cancer ME1 HEL-S-26 CYP11A1 ACLY CYP17A1 HMGCR FASN MAL PMC2742086__F2 Functional and structural organization of migratory mesenchymal cells NUMB APC GSK3B ARHA RAC1 CDC42 PMC8946764__F2 Unravelling the Role of Kinases That Underpin Androgen Signalling in Prostate Cancer HIPK2 MAP2K4 EGFR MAP2K3 STK39 IL6R MAP2K6 CDK6 CCND1 CDK4 CDC2 HK2 WNK1 CNKSR3 MAP2K5 CDK8 CAMK1 ERBB2 CHKA PFKFB2 ADPGK SRPK2 COASY WNK2 CDK9 CAMKK2 STAT3 PMC5907676__F3 Cross-talk between Wnt and signaling pathways SIAH1 GSK3B EZH2 MTOR PMC3543749__F2 Telomere maintenance pathway NHP2 TPP1 NOP10 TERT PMC3543749__F1 Insulin/IGF-1 signaling pathway SIRT2 PHLPP2 SOCS3 PTEN BCL2L11 CCNG2 CCND2 INSR SIRT3 TNFSF6 CCND1 SGK1 RBL2 IRS4 IGF2 IRS1 FOXO1 BCL6 SGK2 IGF1 SIRT1 SOCS1 SKP2 PHLPP1 AKT3 PMC3766375__F3 Fat side of Prostate Cancer HEL-S-26 MYC PTEN ACLY MTOR HEL-S-133P HMGCR FASN MAL PMC3408141__F8 The molecular pathway required for NOD2-dependent autophagy ULK1 ATG16L1 PPP2R1A NOD2 PMC2615558__F4 Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus CD47 PLAUR CSF3 FOS HEL-S-99n FBN1 ATF3 PLAT RYBP SPI1 TIMP3 CASP9 PRRX1 CASP8 RBL1 PMC8467246__F1 Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency YTHDF2 ISG15 METTL14 METTL3 ISG20 CXCL10 ALKBH5 APOBEC3G IRF-1 MX2 MX1 USP18 PMC7037436__F8 Andrographolide biosynthetic gene activation by MJ elicitation in Andrographis paniculata MVK IPMK IPP PMC7226813__F4 JNK enhances fibrosis via crosstalk with TGFB, PDGF, STAT3, and WNT signaling pathways FOS SMAD2 IL6 JUN STAT3 PMC7226813__F3 JNK modulates keratinocyte production of inflammatory cytokine/chemokines and recruitment of immune cells in psoriasis CYR61 CCL20 IFNG PMC7226813__F2 JNK regulation of cell cycle progression, cell adhesion, and cell apoptosis BAD TRADD FOS MMP9 CCND1 TRAF2 JUN BAX PMC7226813__F5 Differential roles of JNK1 and JNK2 in skin cancers CYLD FOS ATF2 SHH JUN PMC4973244__F8 Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway TLR4 MYD88 STAT3 PMC6203147__F10 Activation of EGFR/PI3K/Akt signaling pathway LRIG1 BAX PMC8338901__F2 Contributions of EV cargoes in inflammation in CVD CD47 VCAM1 IRAK1 TRAF6 MYD88 MTOR CD36 PMC5745765__F8 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC5943524__F8 Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 SPHK1 SPHK2 PMC5745765__F7 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC5745765__F6 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC3321383__F2 Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond BACE1 APP PMC5745765__F5 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC5745765__F4 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC209479__F2 Inhibitory effects of SOCS-3 and SHP-1 on LIF-mediated gene expression LIF STAT3 PMC5369969__F14 HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo TSC2 ULK1 BAD ATM HDAC10 HDAC11 HDAC2 RAF1 MCL1 MTOR HDAC5 BAX PMC209479__F1 Corticotroph SOCS-3 as an intracellular suppressor of cytokine signaling POMC LIF PAH STAT3 PMC7760347__F2 Mechanisms governing bile acid (BA) enterohepatic circulation GPBAR1 FGF19 PYY FGFR4 PMC8285010__F1 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol UBC ME1 OLR1 PLTP CYP8B1 UCP1 AQP7 HEL-S-28 LPL NR1C1 CYP7A1 PMC8285010__F2 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol LRAT RETSAT CYP1A1 DHRS4 CYP4A11 RPE PMC5777317__F1 Regulation of the immune response by the aryl hydrocarbon receptor AIP AHRR AHR PMC8427239__F1 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine DUSP14 MYC CYP4Z1 PTEN FOXO1 STARD13 PMC8427239__F3 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine RYBP NRP1 VEGFA YY1 PMC5745765__F9 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature HGF CD1A IL33 TSLP TGFB1 IFNG PMC9399743__F1 Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism ERG SMO IPP CPO PMC8188681__F2 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma BAD MYC MDM2 CDK4 EIF4E HIF1A CDK6 PMC4065011__F5 Ablation of Coactivator Med1 Switches the Cell Fate of Dental Epithelia to That Generating Hair TWIST2 EMILIN2 PRELP SOX9 FOXA1 ANGPT4 SHH VWF MFAP4 JUN KRT1 KRT10 EGR1 KRT16 VWA2 ANGPTL4 FOS CHST1 CD44 S100A9 WNT3A S100A8 IGFBP2 TGM1 ANGPTL7 PMC9941074__F2 Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19 TBK1 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 TLR3 STAT1 NLRP3 TLR8 TLR7 HEL-S-11 TYK2 JAK1 ACE2 TMPRSS2 MAVS PMC8188681__F1 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma FGFR1 ALK EGFR GRB2 SOS1 PMC4973584__F1 Lmx1b and miR135a2 in modulating the Wnt pathway and influencing midbrain size, mDA progenitor specification and neurogenesis APC WNT1 GSK3B CCND1 LMX1B PMC7431397__F2 GPCR-mediated proinflammatory signaling via signalosomes and endosomes BCL10 CYLD MAP3K7IP1 PMC3060239__F5 Model of the RBP-ROH/STRA6/JAK/STAT pathway SOCS3 PMC8341163__F3 Cas-induced nick processing and strand replacement FEN1 PARP1 LIG1 DNA2 PCNA PMC6701981__F1 Muscle Wasting Diseases: Novel Targets and Treatments KLF15 IGF1R SOCS3 TFEB IGF1 BCAT2 SMAD2 GHR MSTN TNF IRS1 STAT3 PMC8341163__F4 CBE outcomes in gDNA REV1 POLE POLK LIG1 POLN CIT PCNA PMC9397555__F2 Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications MFGE8 SRC ARHA AXL CD36 PMC11008420__F1 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma EGF HGF ZEB2 EGFR GRB2 CCND1 PTEN CDH2 MTOR PMC11008420__F2 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma SMAD2 ZEB2 APC CD44 TGFBR2 SMAD4 CCND1 CDH2 STAT3 PMC5665169__F3 RNA editing-dependent epitranscriptome diversity in cancer stem cells NUMB PABPC1 HOXA9 MYC TSPAN3 IKZF2 EIF4G1 MSI2 PMC7407942__F1 Schematic process of the autophagic pathway ULK1 ATG12 EGFR VPS18 PTEN ULK2 ATG10 DKFZp686F0183 RHEB TSC2 TSC1 TFEB SESN3 MDM2 BNIP3L UVRAG BNIP3 ATG14 PMC4754448__F1 Actin associated proteins regulate YAP activity TEAD3 PATJ AMOT NF2 TEAD4 LATS1 RHO PTEN LPA LATS2 TEAD2 PMC4716054__F1 TrkB-mediated signaling pathways and possible therapeutic targets in cancer BAD GRB2 MTOR BDNF PMC7072634__F1 Ultra-structures, components, and functions of intermitochondrial cement (IMC) and mitochondria-associated ER membranes (MAMs) in male germ cells are summarized MAEL DAZL TES GTSF1 XRN1 TDRD6 TDRD1 HIG-1 MOV10L1 PMC3507180__F2 Hypothetic regulation of gene expression by HNF-4A by spherical cell shape in FLC-4 cells NR2F2 VEGFC HNF4A TNFAIP6 MYC ABCC2 NR1C1 NCOR2 ALDH2 PMC2746202__F1 Pathway from PI3K to TOR TSC2 PTEN RHEB PMC5773178__F2 Signalling pathway impact analysis of gene expression data from H226 MM cells expressing C91A-mutant (mt BAP1) or wild-type BAP1 (wt BAP1) BAD NGF TRADD ATM FES MYD88 TRAF2 FADD PMC7405480__F3 The PI3K/AKT pathway by binding and ubiquitylation of tumor-regulating proteins in gastric cancer DAB2IP PTEN WWP1 SMURF1 PHLPP1 PMC7405480__F2 The p53 signaling pathway by binding and ubiquitylation of tumor-regulating proteins in GC MDM2 MKRN1 TRIM59 RFWD2 PMC9669386__F1 Ferroptosis in lymphoma: Emerging mechanisms and a novel therapeutic approach STAT1 GPX4 LPCAT3 STEAP3 SCD SLC7A11 ATF4 HEL-S-64p HEL-75 SLC3A2 ACSL3 PMC7405480__F1 Important signaling pathways by E3 ubiquitin ligases in gastric cancer RNF43 RNF185 UBR5 RNF6 ARHA RNF38 TRAF2 FBXW7 STAT3 PMC9121204__F1 Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review) EPO TRADD RIPK3 NACA MTOR FADD MLKL STAT3 BAX PMC6721579__F4 Role of heat shock protein 27 (HSP27) in different cellular apoptotic processes FADD BAX PMC9548139__F1 Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study HSD17B12 SULT2A1 CYP11A1 SULT1E1 CYP17A1 CYP21A2 STAR CYP11B2 PMC11747284__F4 Schematic represents the PRLR signaling pathways, including both long and short isoforms FYN PRLR GRB2 IRS1 PMC6133069__F8 Schematic depiction of the results and proposed hypothesis FYN NNT ADRBK1 PMC8657749__F1 Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications MOS IPP MVP PMC7751007__F3 Notch signaling pathway MAML1 EGF ECD CCND3 HES1 PMC5019383__F3 DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions CD14 EGF NGF TRADD IFNE RELB LTB TRAF6 TRIM23 CNTF COX2 LTA TLR4 BCR ATM BASH LYN LBP SYK LAT TIRAP PMC10374640__F5 Pharmacological mechanism of Beta-elemene in the treatment of esophageal cancer revealed by network pharmacology and experimental verification BIRC5 EGFR BCL2L1 PTEN RB1 HIF1A MTOR CHEK2 CASP9 CCND1 CDH2 ABCB1 BAX IL10 CDKN1B PTGS2 MMP9 VEGFA IL6 TNF CDKN1A NFKB1 MYCL BCL2 HEL113 PCNA STAT3 PMC8583837__F3 Long Non-Coding RNAs in Endometriosis MMP2 MMP9 CREB1 PMC3436227__F2 MyD-88 dependent TLR signaling pathway TLR7 TLR4 TLR9 IRAK1 TRAF6 IRF3 IRAK4 MYD88 TLR1 PMC8900001__F2 Glycolysis in the progression of pancreatic cancer HEL-S-30 GEM HEL-S-68p HEL-S-162eP PMC4422156__F1 Schematic of TLR signaling and gene expression following stroke TLR7 TLR4 IRF3 MYD88 TLR3 BAX PMC8900001__F1 Glycolysis in the progression of pancreatic cancer GEM UHRF2 UQCRC2 PMC3358876__F1 H. pylori-induced miR-155 expression in macrophage immune cells TLR4 TSPAN14 LPIN1 PMAIP1 MYD88 TLR1 PMC6372777__F2 Figure describes the different effects of gut and brain serotonin on the osteoblast TPH1 HTR1B ATF4 APC GSK3B CCND1 CCND2 CCNE1 PMC4422156__F2 Poly-IC postconditioning activates the TLR3/IRF3 signaling pathway and increases the IFNB levels and subsequently downregulates TLR/NFKB signaling to decrease the levels of pro-inflammatory cytokines TLR4 IRF3 MYD88 TLR3 PMC5624635__F1 MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response ATM MDM2 ATR PMC4904898__F2 PI3K/AKT pathway TSC2 RICTOR TSC1 PTEN MTOR RHEB PMC6000073__F1 LKB1及其下游相关靶点信号通路示意结构图Schematic illustration of LKB1 signaling pathway and related downstream targets for cancer therapy COX2 MTOR PMC3250525__F3 Visualization of the quantity of genes differentially regulated by Gamma-tocotrienol (GT3) and Alpha-tocopherol (aTOC) using the KEGG cell cycle pathway E2F4 SMAD2 SMAD4 SKA2 ORC3 ORC2 CDC6 F2 CDK2 MDM2 PCNA SKP2 MYT1 PMC10757967__F3 Advances in the regulatory mechanisms of mTOR in necroptosis RIPK1 TRADD RIPK3 MTOR TRAF2 CASP8 FADD MLKL PMC10757967__F2 Advances in the regulatory mechanisms of mTOR in necroptosis TRADD RIPK3 TLR3 ZBP1 KL RIPK1 TLR4 CYLD TRAF2 OTULIN CASP8 FADD MLKL PMC5547476__F9 Cartoon depicts the role of MYBL2 and FoxM1 in glioma progression MYBL2 MMP2 FOXM1 CDK2 CCND1 PTEN CDH2 BAX PMC10757967__F1 Advances in the regulatory mechanisms of mTOR in necroptosis TTI1 CASTOR2 ARF1 DEPTOR RHEB PMC8750056__F2 Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models PI3 GRB2 PTEN PMC5306280__F1 Activation of the canonical NFKB pathway PLCG1 LCK ZAP70 TRAF6 SYK TNF TRAF2 PMC7250567__F6 Proposed model of K. pneumoniae-stimulated signaling pathway SCAP2 SIRPA SYK PMC2695202__F2 Emerging anti-inflammatory therapy CXCL1 CCR2 IL8RB HDAC2 CCL2 SLPI PMC7957534__F3 Role and regulation of CTHRC1 in canonical and noncanonical Wnt signaling DAAM1 DPAGT1 APC ARHA ROR2 RAC1 CTHRC1 PMC7957534__F2 CTHRC1 modulating collagen deposition and vascular repair following injury through the TGFB signaling pathway SMAD2 SMURF2 SMAD4 CTHRC1 PMC9261164__F2 Pleiotropic effects of cell competition between normal and transformed cells in mammalian cancers S1PR2 LILRB3 RHO HEL113 PDK4 EPHA2 PMC6817417__F1 PI3K/Akt signaling pathway regulated by PTEN MDM2 PTEN MTOR PMC5157014__F3 Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice INA CNOT8 F2RL3 ELP6 CDCP2 TTN ECT2L FEZF1 PAG1 ZNF761 TRIM50 DNAH7 NCAN PMC484174__F8 A testable model for the modulating role of Dcs1 in the yeast stress response MGP DCP2 EIF4E PMC2692634__F1 THE ENZYMES OF THE 10-FORMYL-TETRAHYDROFOLATE SYNTHETIC PATHWAY ARE FOUND EXCLUSIVELY IN THE CYTOSOL OF THE TRYPANOSOMATID PARASITE LEISHMANIA MAJOR FTL MTHFD1 MTHFD2 PMC11658190__F2 Functions of the Ddx family in the development, differentiation, and homeostasis of oligodendrocytes DDX54 MBP MDM2 DDX5 PMC7868698__F2 Deep Look into the Program of Rapid Tumor Growth of Hepatocellular Carcinoma REN ATM SI MYC RB1 SMC1B ORC2 PMC9155226__F1 Trimming the fat: is there a health economic case for the use of new lipid-lowering drugs in chronic kidney disease? A scoping review ABCG1 LPL LDLR LPA PMC11658190__F4 Dual inhibition mechanism of the p53 pathway by Olig2 GEMIN6 MDM2 GEMIN7 GEMIN8 GEMIN2 GEMIN5 OLIG2 PMC10610144__F7 SBP effects on BMP2-Smad1/5/9-Runx2 signaling pathway SPARC RUNX2 BMP2 SMAD1 DKFZp781O1323 SMAD9 PMC9178561__F6 First study on the effect of crocodile oil from Crocodylus siamensis on hepatic mitochondrial function for energy homeostasis in rats RPS6KB1 RICTOR ACLY EIF4EBP1 MTOR RPTOR CFTR HDHD3 PMC2897911__F1 Induction of Type I Interferons by Bacteria TLR8 TLR7 TLR4 TLR9 MYD88 TLR3 PMC6337367__F1 Kinases in the insulin signaling cascades and its interaction with nutrients in control of FOXO1-mediated physiological function AgRP OGT PTEN HMOX1 IRS1 PMC9513079__F2 Interaction between LSC and BMM CXCR4 MSC CD44 CXCL12 MTOR PMC6429987__F2 AMPK-mTOR signaling pathways during Mtb infection ULK1 TFEB IRGM MTOR NOD2 PMC6429987__F1 Brief summary of reciprocal regulation between AMPK and mTOR pathways TSC2 TSC1 MTOR RHEB PMC7349502__F2 N-glycan trimming of the HBV envelope glycoproteins SEL1L EDEM1 EDEM2 EDEM3 PMC7434793__F1 Resistance to BRAF-targeted therapy EGF BRAF EGFR KIAA1549 MTOR PMC7232129__F7 HBV-miR-3 activation of innate immunity to restrain HBV replication STAT1 IFIT3 OAS1 IFIT2 IFNAR1 MX1 PMC4590661__F3 Regulation of autophagy by the MTORC1 signaling pathway in cancer cells RRAGD ULK1 PIG59 SQSTM1 ATG101 TSC2 SLC7A5 TSC1 TFEB ATM RRAGB RRAGA GLUD1 GLS RB1CC1 PMC5716985__F1 Mechanism of epithelial-to-mesenchymal transition (EMT) EGF HGF CDH2 FOXC2 PMC8319800__F3 Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models NLRP3 HMGB1 TNF PMC8491217__F2 Lipid metabolism in cancer progression and therapeutic strategies PGC LATS1 ACLY LATS2 FASN PMC5834531__F6 This figure summarizes the central s-resistin downregulation effects on hypothalamic and peripheral insulin and leptin sensitivity POMC NPY IRS1 STAT3 PMC9062983__F1 Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism NLRP3 BCL2 CAD SDHA BAX PMC8232269__F4 One Hundred Candidate Genes and Their Roles in Drought and Salt Tolerance in Wheat PC TF PMC7105613__F1 Tryptophan catabolic pathway IDO1 HAAO HEL-S-90n KYNU IDO2 PMC8789279__F7 Schematics for the BNP-NPRC facilitated signaling pathway and distinct neuropeptide pathways for histamine-dependent and -independent itch NMB GRPR NMBR ITCH PMC7246682__F6 Action of fractalkine on JEG-3 trophoblast cells Fractalkine binds to its cognate receptor on the surface of trophoblast cells activating MAPK and AKT pathways CX3CR1 MMP2 BMP2 CX3CL1 SMAD2 MMP9 PMC6029864__F1 Notch signaling on T cells MAML1 APC CTLA4 PMC11535288__F7 Overall metabolic pathways altered in systemic (plasma) and lung tissue of OVA-induced asthma mice after BS012 administration PC TG PMC7905103__F5 Diagram depicting a potential mechanism of interactions CD14 TLR4 LBP BPI PMC11722561__F1 Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease VIT CRP IL6 TNF TF PMC8137704__F4 Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian Indians HIPK2 HDAC3 CSNK2A1 TP63 NFE2L2 MAPK3 MAPK14 NR0B2 PPARGC1B FOXA2 HNF4A PPARGC1A CDK2 CDK4 MAPK1 MYOD1 SUMO1 PMC2859933__F9 Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases ENSA HEL-S-11 FOXP2 DES CSF2RA PMC6948367__F3 Alternative STING pathway activation ATM TRAF6 IRF3 IL6 MAP3K7IP1 IRF-1 PMC11879837__F10 Illustration of the JAK2/STAT3 and PI3K/AKT signaling pathways implicated in the protective effect of SM on kidneys injured by DN TNF MTOR STAT3 BAX PMC6948367__F2 Canonical STING pathway activation TBK1 CGAS CXCL10 IRF3 CCL4 IL6 IFI16 PMC4121105__F1 KEAP1/CUL3/RBX1 E3-ligase protein complex KEAP1 RBX1 PMC6948367__F1 Homologous recombination repair pathway (adapted from De Picciotto et al.) PALB2 BRIP1 MDC1 MRE11A BRCA1 RNF8 ATM BRCA2 RAD50 RAD52 RAD51 ATR H2AX PMC3298518__F2 Pathogenesis of neurodegenerative diseases is significantly associated with oxidative stress MAF KEAP1 NQO1 PMC3973444__F7 Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders TSG101 ISG15 CHMP6 CHMP5 CHMP2A PMC6885354__F4 Analysis of miRNA expression profiles in the liver of Clock-delta19 mutant mice SNAI1 MAPK9 IQGAP3 CRY2 GRPR MAPK3 NRAS HIF1A ATAD2 TAOK1 NOTCH1 SP1 TCF3 MAP3K1 PAFAH1B1 BAK1 ADCY1 FZD4 TNF HTR4 FBXW11 FZD5 CBX4 PLCB1 LPAR4 RICTOR DUSP10 CDKN1A PPM1D RBBP7 AXIN1 PPP2CA PRKCH RPS6KA2 PER3 AKT3 YES1 RGMB CCND2 MEF2D FKBP1A IKZF1 PDS5B APP RGS1 SFRP1 ETS2 YWHAG RHOB SGK1 PER2 PER1 MYBL2 FBL CALCA BMP2 PPP2R5A RAC1 CBL LEF1 EP300 MAP3K2 SMG1 ZWINT SETD2 PPARG TUBB4A SP3 CHD9 CARM1 TBPL1 GNB2 CDK19 ETV6 RALA RAP2C MAP2K6 SMARCA5 BATF ACVR2A NR1D2 RAD21 ADM BAP1 ROCK2 BHLHB2 RHOBTB3 FOS ATF3 GADD45A IMP3 SH3PXD2B FOXO1 STAG2 HMMR IQGAP1 SUV39H2 CXCL9 MED13 RND1 SIRT1 DYNC1H1 BTRC CASR HGF MAP2K4 PAK4 PTEN RGS18 CACNB4 CRYZ INSR ITSN2 SUCNR1 PTPN1 FZD7 DDX5 JUN GATA3 EPHA4 KAT2B GPR55 NFATC1 PLK4 SMAD6 PRKG1 S1PR3 CENPK GATA2 MYO5B TUBGCP5 ADRA1B QRFPR MAP2K1 MYF5 MAK16 NFIL3 RAF1 MED26 NR1D1 EPHB2 ARID4A PMC3574816__F1 Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention APC GSK3B PMC7403467__F1 Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll IL10 PDC TLR9 MYD88 IL4 IFNG PMC5148003__F1 AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells LEF1 MMP2 ACTA2 SMAD2 TGFBR1 TGFBR2 COL1A1 PMC5082787__F10 Schematic illustration of Ro inhibiting autophagic flux and sensitizing chemoresistant esophageal cancer cells to 5-Fu-induced cell death NR3A2 CYBB NCF1 CHEK1 PMC9166453__F2 Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases ATF2 RHO MTOR CDC42 BAX PMC5864191__F2 Mevalonate pathway and mutp53 PMVK MVD FDPS MVK RHO MVP PMC3583581__F2 Recent advances in prostate development and links to prostatic diseases MMP2 SHH BMP7 SFRP1 SMO PMC8616517__F3 Kinase Inhibitors’ Effects on Innate Immunity in Solid Cancers APC PMC8900217__F2 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling CGAS APC CCL22 PMC3146975__F3 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 PLEC TP63 ATF1 FPR2 KCNC2 SRGAP3 GNAI1 IKZF1 ADRA2A IKZF4 MT1E GALR3 CXCR4 GNAI3 CDC42 PMC8900217__F1 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling TBK1 CGAS IRF3 PMC5864191__F4 Functional association between mutp53 and mevalonate pathway-associated oncogenic proteins (Ras, RhoA, YAP/TAZ) EGFR ARHA PMC3146975__F1 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 FYN CREM GRB2 SRC SYK SHOC2 SHB JUNB CSF1 LAT PMC9357935__F2 Research Progress of Myocardial Fibrosis and Atrial Fibrillation TLR4 MYD88 TNF PMC10387486__F4 Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets SUN1 PIEZO1 HEL-S-28 SMAD2 SMAD4 ARHA BTBD7 SMAD1 TGFB1 DKFZp781O1323 PMC9281132__F2 Wnt signaling in colorectal cancer: pathogenic role and therapeutic target RNF43 APC LRP6 DKK1 RSPO4 PMC11578537__F7 Iron-dependent hepatic regulation of hepcidin HAMP HFE TFR2 STAT3 PMC3583581__F4 Recent advances in prostate development and links to prostatic diseases FOXA1 SHH PTEN PMC4172644__F1 Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism HEL-S-61p MTR VIT FOLH1 MTRR TCN2 MTHFD1 SLC19A1 PMC1601945__F1 Model of RNF11 interactions in the TGFB receptor signaling pathway RNF11 SMURF2 SMAD4 PMC2685981__F1 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis CD9 PRKCZ BCL7A INS NFKBIZ HSPD1 TLR4 GOT2 PC FAP IL4 SP1 IFI16 SVIL ASPSCR1 IL1A SCARB1 WASF2 IL13 PDE4DIP TNF LEP LMO4 SDC4 CXCR4 RELA ATP2B2 LITAF SCN5A COL24A1 CD36 PMC5979336__F10 Scheme of possible signaling pathways involved in regulating the functional state of Cx43 HCs, Panx1 Chs, P2X7Rs and Cx GJs in mesangial cells stimulated with AngII ARHA PANX1 IL1B PMC12188374__F2 (1) Treatment with EGFR-TKI or KRAS inhibitors may lead to AST KRT6A CXCL5 CXCL3 STAT3 PMC12188374__F1 (1) The EML4-ALK fusion protein produced by ALK rearrangement can activate the JAK-STAT signaling pathway ELF5 SOX2 FOXM1 ALK CXCL5 MYC CXCL3 TET2 FOXA2 NKX2-1 VEZF1 FOXA1 ZEB2 STAT3 PMC7166227__F3 Different mechanisms are triggered when stimulated by the different nucleotides in the CeCa TME EGFR UMPS PMC2685981__F3 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis CD9 HGF CSF3 MAPK14 NFKBIZ PTEN HSPD1 CD81 POMC SRC SHH IL4 IL1B GATA3 SCARB1 IL13 PF4 ENG TNLG2B IL5 BCL6 IL15 CXCR4 TGFA PPARG TGFB1 PMC5228603__F3 Reparative inflammation takes charge of tissue regeneration WNT3A APC LRP5 LRP6 IL11 ROR2 LATS1 RHO LATS2 ROR1 STAT3 PMC4357208__F1 Metabolic network for flux analysis CIT TK1 MAL PMC5829655__F1 Hypothetical model summarizing the probable mechanisms of severe inflammation in malaria TRAF3 MYD88 IL1B GATA3 PMC1526546__F1 Innate model of lupus pathogenesis: central role of TLR-activated MZ-B cells and pDCs PDC TLR9 CD40 PMC4196647__F2 E-cadherin on RTK signalling STAT1 ERBB4 EGFR MDM2 PMC6336458__F1 Molecular mechanisms of viral oncogenesis in humans MAML1 TLR4 BCR FOXM1 IRAK1 APC TRAF6 CD40 ADAM10 PMC3887674__F1 Factors influencing the reprogramming of unipotent SSCs into pluripotent stem cells SOX2 NANOS2 GDNF TAF4B PMC8866866__F1 Nerve Dependence in Colorectal Cancer MMP7 COX2 NGF MMP9 EGFR GDNF CDH2 BDNF PMC8517930__F7 Novel insights into the regulation of LATS2 kinase in prehierarchical follicle development via the Hippo pathway in hen ovary TEAD3 NR3A2 STK4 FSHR LATS2 STAR PMC3788359__F3 Pathways linking hypoxia to CSCs and EMT in tumor aggressiveness SOX2 ZEB2 IGF2 BNIP3 PMC7059351__F2 Alteration of synthesis and degradation pathways of glycosphingolipids in the physiopathology of HSP B4GALNT1 GBA2 PMC6805914__F7 EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells EIF2A MYC SRC EPHB4 PMC4476649__F1 Regulation of Lymphocyte Function by Adenosine CD1D IL4 FOXP3 PMC4088370__F3 KEGG Cell-cycle pathway RAD21 CDK7 PCNA SKP2 MYT1 PMC6627635__F3 Predicted/established targets of selective flavonoids in platelets: Flavonoids modulate platelet activation through multiple mechanisms FYN COX1 SYK LAT PMC4088370__F2 KEGG MAPK signalling pathway NF1 CD14 HRG NGF ECSIT PMC11280061__F6 Auxin-regulated TFRN attenuates lignin biosynthesis CCR2 CAMTA1 IRX4 PMC9204003__F2 Long Noncoding RNA and Circular RNA: Two Rising Stars in Regulating Epithelial-Mesenchymal Transition of Pancreatic Cancer SOX2 SOCS3 TGFBR1 EGFR TGFBR2 ARHA FOXD1 STAT1 NLRP3 HOXA13 FGFR1 DYNC2H1 TUG1 EZH2 SOCS5 NT5E PMC11280061__F7 Auxin-regulated TFRN attenuates ABA transport, conjugation and signaling FER GPX3 CAMTA1 ABI3 PMC3415708__F5 Novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer ACADVL FH ACO2 OGDH HEL-S-87p PCK2 ECHS1 HEL-S-133P SDHD MCAT GCDH PMC3415708__F4 A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer APP MAOA OGDH SDHD PMC4088370__F4 KEGG Apoptosis pathway NGF TRADD TRAF2 FADD PMC7063119__F1 Apelin/APJ system–mediated signaling pathways KLF2 HDAC5 PMC12208858__F2 Intravascular release and mechanism of pH-responsive TwHF nanocarrier VCAM1 ICAM2 TNF STAT3 PMC3568227__F2 Role of mesothelin in cancer progressionOverexpression of mesothelin leads to higher IL-6 production by constitutively activating NFKB BAD CDK2 MSLN STAT3 BAX PMC3088358__F7 The extracellular network of proteins that control D–V patterning BMP2 BMP7 BMP4 PMC305326__F1 The development, activation, and maintenance of the satellite cell HGF IGF1 MYF5 PAX7 PMC4273559__F2 KEGG pathways significantly associated with NPG HHIP ALDH3A2 CACNA1C PRKCA FYN CACNG4 WNT4 WNT8B CD14 GADD45G XYLT1 EXT2 BMP7 BDH1 HMGCS1 RAC3 PLA2G4B CACNG5 EVI1 WNT10A MAPKAPK3 SOS1 ECHS1 MEF2C EHHADH PMC3554567__F4 Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry NODAL SMAD4 FOXH1 PMC5423040__F2 Hunger-satiety circuit and energy balance POMC GHSR NPY AgRP MC4R PYY ARC LEPR INSR PMC8906956__F8 Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO-1 Signal Axis GPX4 SLC7A11 SLC3A2 PMC4273559__F3 Butanonate metabolic pathway (KEGG pathway hsa00650) GAD2 OXCT1 ALDH3A2 OXCT2 BDH2 ACSM2A ALDH5A1 ACSM5 ACSM2B ALDH7A1 ACAT1 ACADS PDHA1 L2HGDH ALDH9A1 PDHA2 AACS HMGCL BDH1 HMGCS1 GAD1 ACSM3 ACAT2 ABAT ACSM4 ECHS1 EHHADH ALDH2 PMC4929427__F2 Cross-talk of mammalian Hippo signalling with the MAPK, PI3K and intrinsic and extrinsic apoptotic pathways PML EGR1 RUNX2 AMOT AIFM1 WBP2 ATM MDM2 BCL2 CDC2 RAF1 ATR ARAF BAX PMC5954090__F7 The metabolic characteristics of a low-carnitine zebrafish model LPL MTOR INSR PMC8804323__F1 FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling CYP27A1 CYP8B1 CYP7B1 CYP7A1 HSD3B7 PMC7242447__F3 Genetic variation and evolutionary history of a mycorrhizal fungus regulate the currency of exchange in symbiosis with the food security crop cassava RAD1 CS PC PDHA1 DLD GPD2 LPA DLAT PMC4061845__F2 Sphingolipid involvement in ethanol-induced apoptosis in the P7 mouse brain GSK3B S1PR1 SPHK2 BAX PMC7326156__F7 Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E EIF4E RPS6 MTOR PMC9178120__F5 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors SLC7A11 VCP PHGDH PMC2413330__F3 Working hypothesis on the mechanism by which plasminogen activator inhibitor-1 (PAI-1) causes hepatic steatosis HGF TNF MTTP PMC9178120__F4 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors RAE1 GLS2 SLC38A1 PMC9178120__F2 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors IL10 CCR5 IGF1R HGF VCAM1 CXCR4 IL6 SLAMF7 DKK1 CCR8 CCR1 PMC8920443__F37 2022 WHO Classification of Adrenal Cortical Tumors CACNA1H ATP1A1 MC2R KCNJ5 ATP2B3 PMC11005288__F5 Compound Shenma Jingfu granule alleviates cerebral ischemia via HIF-1Alpha-mediated promotion of angiogenesis TLR4 EPO DAO MAFK VHL TFRC HEL-S-87p RPS6 MTOR HEL-S-133P TF HEL-S-162eP PMC8721229__F4 Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial VCAM1 PTEN PMC4371960__F6 E2-induced signal transduction pathways in the uterine epithelium leading to DNA and protein synthesis IGF1R IGF1 GSK3B RPS6 MTOR PMC5877395__F1 Annexin A2 (ANXA2) in cancer progression SOX2 S100A10 PLG MIEN1 ANXA2 CDH2 PMC8533518__F1 Enhancement of Beta-Alanine Biosynthesis in Escherichia coli Based on Multivariate Modular Metabolic Engineering ASPA CIT MAL PMC6006330__F8 BMP2/4 increase neurogenesis from adult hippocampal NSPCs and synergize with WNT3A LEF1 BMPR1A BMP2 BMP4 PMC5622154__F2 Differentially expressed genes upon congenital neonatal human cytomegalovirus (HCMV) infection form distinct subnetworks IFIT3 HEL-S-134P ALAS2 GBP5 BCL2L1 SLC4A1 CDC34 DPM2 EPB42 STAT1 GBP1 HEL-S-11 TRIM58 HAGH PRF1 ST6GALNAC4 MYL4 ERAF ADIPOR1 GRINA RBM38 RSAD2 ATP6V0C OSBP2 FBXO7 GUK1 GC20 GMPR GYPE UBXN6 NKG7 RUNDC3A TNS1 R3HDM4 GBP4 RNF10 GYPB GZMH PMC12222446__F1 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias PIG59 AMD1 MTAP GPC1 ARG2 SMOX SRM PRODH PAOX SLC3A2 ARG1 SMS GLS PMC3395153__F1 Roles of Platelets and the Signal Transductions Identified as the Major Cascades in Hepatocyte Proliferation HGF IGF1 IL6 MTOR TGFA STAT3 PMC5661633__F2 NFKB in the regulation of NLRP3 inflammasome NLRP3 TRAF6 MYD88 MAP3K7IP1 IL1B PMC9647118__F2 Homologous recombination PALB2 BRCA2 BARD1 RAD51 PMC12222446__F5 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias MTAP ARG2 SMOX SRM PAOX AMD1 ARG1 SMS PMC4673348__F5 Proposed schematic showing targets of SA transcriptional regulation of insulin signaling pathway PRKCZ GCK MTOR INSR PMC9368916__F3 Comparative Transcriptome Analysis Reveals Coordinated Transcriptional Regulation of Central and Secondary Metabolism in the Trichomes of Cannabis Cultivars MVD GAS1 IPP PMC6913448__F1 Structures of CLEC-2 and podoplanin BTK SRC SYK LAT PMC4134368__F2 Biosynthesis of spiruchostatins SPIB AMT PMC2844056__F7 Genes involved in cell-cell signaling significantly associated with ERbreast cancer cells in response to AA COL11A2 BAD CST5 NLRP1 SRPX AVEN CASP9 CARD8 CASP10 TNF BAX PMC2844056__F6 Insulin receptor cascade was uniquely up regulated in ER− cells when treated with AA NR3A2 CSF3R NR3C1 VEGFA LTB SMAD4 RCAN1 VPREB1 HAS2 NTF3 LTA KHDRBS1 SPIB IL4 IRF4 TRAF4 PMC2844056__F5 Ingenuity pathway analysis of genes up regulated in ER+ cell in response to AA shows that the ERK/MEK pathway was significantly associated with ER+ BAD TRIM2 STAT3 PMC2844056__F2 Ingenuity pathway analysis and expression profiles of genes involved in apoptosis that were uniquely up regulated in ER+ cells in response to EPA STAT1 RPL36 PAWR PHIP RAD21 PMC4052811__F2 Deduced pathway of sterol biosynthesis in N DHCR24 SMO IPP PMC3114846__F5 Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases ASIP HOXA9 KLRB1 KLRK1 DCT ABCB5 STX17 HOXD12 PMC11674819__F2 PD-1/PD-L1 signaling pathway APC CD80 PMC8591899__F1 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities CXCL10 IL2 IL6 CCL2 IL-21 IL4 ACE2 MAVS TMPRSS2 IFNG PMC11576170__F3 The ICE1-CBF-COR signaling cascade ICE1 BIN2 PIF1 PMC8591899__F5 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities MAF KEAP1 PMC11576170__F2 Perception and transduction of cold signals in plants ICE1 COG3 CBL PMC6857111__F11 Huaier inhibited breast cancer progression through linc00339/miR-4656/CSNK2B signaling pathway CSNK2B PMC11576170__F4 ROS homeostasis regulates plant cold tolerance TCP1 MYB ENO2 PMC9016203__F5 Therapeutic Applications of Physalins: Powerful Natural Weapons SUFU APC GSK3B LRP5 LRP6 SMO STAT3 PMC9025601__F3 Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex TP73 TNF CYP2E1 CP PMC8518235__F8 Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis LCK GAL LAT PMC8245853__F2 CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment HLA-E HLA-G CXCL10 VEGFA PDPN LAG3 HDAC1 STAT1 COX2 CXCR4 CXCL9 SHH CD80 CXCL12 CSF1 CHI3L1 PMC6680919__F4 Leptin signaling POMC AgRP TPO STAT3 PMC2978002__F7 Model demonstrating the specific apoptotic effect of SREBP-1 and FAS inhibition on GBM cells bearing EGFRvIII EGFR PTEN MTOR PMC11004450__F6 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells NAGK PGM3 OGA OGT GNPNAT1 PMC9601999__F4 Genes Related to Cognition after tDCS in an Intermittent Hypoxic Brain Injury Rat Model RHOD NGF FRS2 SHE SHB RAC1 CRK CDC42 BAX PMC5302168__F8 Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 RASA2 GRB2 RPS6 MTOR SPRY2 PMC6279925__F4 Network visualization of top primary hits NUDT12 XCR1 FZD3 MAPK14 CDC34 FAAP24 PIGM SMO ROR2 NR1D2 OGDH UGT2A1 GRAP BHLHB2 Meflin PTCH2 IGFBP7 VEGFA GCNT1 ADCY3 TOB2 TRPC7 MCM5 KCNJ2 NR1C2 IGFBP6 CRTC1 BLMH NFKBIE SUMO1 FGF20 CLK2 SH3GL3 MOBP CAMK4 GDF15 DIO1 SNX2 GPHN IL2RB CTPS2 RAD1 HEL-S-30 MAFF STXBP4 WASF3 NTS SLC25A4 TACR2 PIK3C2G DOT1L MPG TCIRG1 IL27 PIWIL2 FHL2 SELP CAMKK2 PMC2685661__F10 NO/cGMP and calcium signaling in osteoblast mechanotransduction FOSB PMC9175095__F8 Exosomal CTCF Confers Cisplatin Resistance in Osteosarcoma by Promoting Autophagy via the IGF2-AS/miR-579-3p/MSH6 Axis CTCF MSH6 PMC5649483__F1 Showing a putative Th17/Treg/Th1/Th2 regulatory axis IL13 GATA3 FOXP3 PMC8921682__F3 Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition CHDH CRAT CYP7A1 PMC5436301__F1 DNA repair pathways in mammalian cells RIF1 SSB XPC PARP1 BRCA1 POLE ATM BRCA2 RAD52 RAD51 ERCC1 XPA ATR DNA2 PMC5436301__F2 Interstrand crosslinks can be repaired by replication-independent (left) and replication-dependent (right) mechanisms REV1 POLK SLX4 FAAP24 FANCM ATR BRCA1 PMC11004450__F1 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells NAGK PGM3 OGA OGT GNPNAT1 PMC5436301__F6 Repression of or mutation in several upstream regulators of homologous recombination (HR) can be synthetically lethal with PARP1 inhibition because they can cause a variety of HR repair defects that prevent fork restart POLE BLM RAD51 PARP1 PTEN H2AX USP11 MRE11A WRN PMC7260582__F1 Action of cetuximab, encorafenib and binimetinib EGF HGF EGFR MTOR STAT3 PMC12004712__F10 KEGG “Leukocyte transendothelial migration” pathwayKEGG “Leukocyte transendothelial migration” pathway highlighting the associated AC contrast DEGs VASP CD99 ARHH PROC TEC JAM3 ARHA ITGA4 RAC1 ITGB1 THY1 ITGAM CXCR4 JAM2 CDC42 PMC10526380__F3 Molecular Classifiers in Skin Cancers: Challenges and Promises SUFU PTCH1 MYC MTOR PMC11992302__F2 Six signaling pathways associated with the PD-L1 and PD-1 pathways in melanoma GLI3 PTEN MTOR PMC8154588__F5 Synthetic lethal interactions in SWI/SNF-mutant cancers with chemical tools for targeted cancer therapy SS18 GCLC DKFZp781B1423 CDK6 PS1TP5BP1 ARID1B UBE2C SMARCA4 MDM2 SRC CDK4 EZH2 ATR PMC3848582__F5 Schematic model demonstrating functional involvement of NPM1, RAD50 and XRCC5 in DSB-repair in the progression of ovarian cancer cells XRCC5 NPM1 ATM RAD50 CCND1 CDC2 MRE11A PMC150381__F2 Interplay of the major genetic alteration in pancreatic carcinoma with the cell cycle SMAD4 CCND1 CDK4 CDK6 PMC2672935__F2 Regulated molecules in canonical signalling pathways identified by IPA IL10 SFN HEL-S-99n ARHA CDC37 PTEN RHO TAPBP STAT1 CDKN1A TRAF2 FADD SKP2 PMC6766639__F4 Impact of IT on mitochondrion-related gene expression and on selected mitochondrial outcomes in tissues collected from UCD-T2DM rats at 1.5 mo-post surgery PGS1 CS CDS1 PGP CDS2 PTPMT1 CRLS1 PMC4553756__F3 Delta-1-pyrroline-5-carboxylate synthase (P5CS) pathway OTC ALDH18A1 ARG1 ASL PMC12130906__F2 Regulatory functions of the TGFB/Smad signaling pathway in the renal fibrosis SMAD2 CTCF SMAD4 TNF PMC7582884__F1 PI3K/Akt signal pathway, p53 signal pathway, and mTOR signal pathway in NPC MYH9 EGF SQSTM1 FGF2 EGFR CDKN3 PTEN RBM3 MTOR COL1A1 FOXO1 UBQLN1 MDM2 SMG1 CCND1 MDK PMC11934714__F5 HERV in the pathogenesis of ALS TBK1 CGAS IRF7 IRF3 PMC11934714__F4 HERV in schizophrenia CGAS DRD3 GPX4 DISC1 TRPC3 IRF3 SLC3A2 DRD2 BDNF PMC11934714__F2 The roles of retrotransposons in adult neurogenesis SOX2 SOX11 NTRK3 NAT1 HDAC1 YTHDC1 TUT7 TET1 PMC5856294__F3 GPCR signaling and the organization of the stem cells niche ZNRF3 RNF43 APC EGFR PTH STAT3 PMC4872111__F1 Genes involved in CRC pathway FZD3 BAD SOS2 SMAD2 TGFBR1 APC GSK3B SMAD4 RHO DVL3 DVL1 CASP3 CASP9 BCL2 MSH2 DCC BAX APPL1 PMC9509228__F2 Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy EIF2A FUNDC1 BNIP3 MTOR TRAF2 GABARAP PMC7854732__F10 Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer ERG SPOP TMPRSS2 PMC8001237__F1 An overview of various approaches used in myostatin inhibition SMAD2 MSTN PMC9609640__F7 SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza MYB IPP PMC6925860__F8 The schematic diagram depicts the mechanism of CPP-induced enhancement of sensitivity to TRAIL in ESCC cells FADD FOXP3 PMC4326572__F1 Main molecular pathways activated in the presence or absence of nutrients ULK1 AMBRA1 RHEB PMC4872111__F6 Downstream effects of miR-145 ectopic expression CHUK ATF2 CDKN1B SMAD4 MAP2K3 MAP2K6 CDK6 CCNE1 PAK1 CDKN2B CDKN1A MAX CDK2 GRB2 CCND1 CDK4 RAF1 CDC42 PMC5356793__F4 Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma SYCE3 SYCE1 HES6 HOOK1 ACVR1 CLDN19 CLUAP1 CLDN16 SLC30A5 FSTL3 RAI1 NAA38 ACVR2B CINP HPD ZBTB7C KIF20A TESC ACTL6B STX19 STX8 PI4KB PLEKHB1 SCAMP5 PMC7333179__F1 Proposed estradiol-induced hypothalamic astrocyte steroidogenesis of neuroP that activates a membrane classical progesterone receptor (PGR)-Src tyrosine kinase (Src) signaling pathway in RP3V kisspeptin neurons to trigger the luteinizing (LH) surge PGR KISS1 KISS1R SRC PBR STAR PMC4407676__F2 The two representative networks by ingenuity pathway analysis (IPA) for differentially methylated whole gene set derived from HF-dNK-treated EVT VAV2 PMC5462754__F6 Ingenuity Pathway Analysis showing a network biology system for the interaction between both the miRNAs and the metabolites identified from the metabonomic analysis ADRB1 SYN2 ARHGEF12 RB1 GRIA2 HMGCR INSR CBL CREM APP ADRA1D STX3A ADRB3 PMC3533466__F1 Genes whose mRNA expression is suppressed by nicotine in RAW264.7 cells under poly(I:C) stimulation compared with those under poly(I:C) stimulation only are mapped to three gene networks, as predicted by ingenuity pathway analysis (IPA) IRF7 LBP IL6 FADD TIRAP IFNG PMC3155176__F4 FRAM Is Characterized by Increased Signaling of the BRAF/MEK/ERK Pathway(A) IPA analysis led to the generation of a gene-interaction network of genes differentially expressed in patients DAAM1 BRAF TMEFF2 DUSP2 RASSF4 SELE ENTPD1 PMC8909695__F2 Organic UV Filters Induce Toll-like-Receptors and Related Signaling Pathways in Peripheral Blood Mononuclear Cells of Juvenile Loggerhead Sea Turtles (Caretta caretta) SET LPO RAC1 TLR1 AKT3 PMC11973847__F3 PRR signaling pathways associated with autoinflammatory diseases NLRP3 CGAS RIPK1 NLRC4 IRF3 MAVS PMC7640965__F1 SARS-CoV-2 infection and proliferation process mediated by host and viral proteases PLG TMPRSS4 FURIN ACE2 TMPRSS2 PMC10137236__F1 TGFB signaling pathway SMAD2 TGFBR1 SMAD4 PMC12025273__F6 Mechanism map of cerebral ischemia in JU UBC SUMO2 ELAVL1 NRF1 GRB2 ITGA4 HEL-S-93 JUN PMC2803288__F4 Schematic diagram depicting the pathway via which GC-A signaling inhibits cardiac hypertrophy GCA RGS4 GC PMC3533466__F5 Nicotine’s effect on multiple signal transducers in the downstream pathway of calcium DAG1 PAK1 GAB2 ATF2 VAV1 EGFR MYC GRB2 SRC RAC1 MTOR SHC1 PMC5016702__F8 The signaling pathway by which FSH, via PKA, regulates the PI3K and ERK pathways in GCs IGF1 EGFR IRS1 PMC5130074__F1 Scheme depicting the possible mechanism of VEGFR-2-mediated vascular effects (cell proliferation, survival, migration, and enhanced permeability) related to vascular formation BAD SRC SHB CDC42 PMC5867880__F3 CD99wt and CD99sh in tumor cells ROCK2 CD99 MMP9 PMC4925727__F3 Tyrosine kinase receptors and their signalling pathways involved in angiogenesis BAD EGFR GRB2 SRC PTEN MTOR PMC4427058__F7 The identified epigenetic regulatory mechanism involved in the miR-124/STAT3 pathway in pediatric-UC MMP9 BCL2 STAT3 PMC8288060__F7 Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated APC DKK1 PMC4052206__F6 Ingenuity pathway analysis (IPA) displaying regulatory relationships among highly expressed (green) and lower (red) placental transcripts in less muscular women as compared with women with high arm muscle area MHC2TA LST1 HLA-DRB1 SP100 IFNG C1QB C1QA RELA CD40 PSMB9 IRF-1 PSMB8 ICOS PMC11790818__F3 Notch signaling pathway MYC FURIN PMC4292729__F1 Molecular and cellular mechanisms of immunogenic cell death HEL-S-92n IL1B IFNG PMC9626530__F3 Therapeutic potential of triptolide and celastrol in neurological diseases BACE1 NLRP3 HMGB1 IL33 TNF MTOR PMC9626530__F2 Therapeutic potential of triptolide and celastrol in neurological diseases BACE1 NGF IL8RB MTOR BDNF PMC6535773__F6 Dimensionality and the cell malignancy potential on lipid species amounts in the MCF10A breast cancer in vitro model PC DES TG SMS KDSR PMC9161693__F1 Astrocytic Calcium and cAMP in Neurodegenerative Diseases ADA DES MCU PMC7914425__F5 NOD-like receptor-signaling pathway constructed based on full-length sequencing and annotation results of the skin transcriptome of a sperm whale IRF7 IRF3 NOD2 MAVS PMC5593685__F1 The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy VEGFA HEL-S-133P HEL-S-281 PMC6824681__F10 The SGK3 signaling pathway STX7 STX6 VAMP4 VAMP8 STX8 STX12 VTI1B PMC7595665__F3 m6A modulators involved in cardiovascular disease and bioprocess HGF TFEB HNRNPD XPO6 CALM1 PMC5495885__F3 MiRNA discovery RUNX2 IRF7 NODAL PITX2 SMAD6 AMN SMURF1 NR1i1 TLX2 GRB2 GSC SKI FOXH1 CDC42 PMC8268320__F3 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? IL15 CTLA4 PMC9682260__F4 Alteration of cholesterol distribution at the plasma membrane of cancer cells: From evidence to pathophysiological implication and promising therapy strategy APC CD44 HRAS FADD PMC8268320__F2 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? CXCL16 MICA CCL7 CCL5 CCL2 MTOR PMC12063356__F5 Combined Ibr + AS treatment modulates both upstream and downstream effectors of the BCR (A, B) PI3K-AKT signaling pathways NPB BAD PROC PTEN BLK RHEB CD81 TSC2 BTK BCL10 BCR RAE1 BASH GC CD22 LYN GRB2 SYK RBL2 CD19 PMC3974512__F1 Hepatitis C virus entry into hepatocytes CLDN1 EGFR APOC1 GRB2 LDLR NPC1L1 RHO HRAS EPHA2 SHC1 APOE PMC8268320__F1 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? SMAD2 EGFR SMAD4 NOX4 RHO FURIN TF PMC7682108__F1 Intracellular cholesterol homeostasis ABCG8 ABCG5 ABCG1 LDLR ABCA1 HMGCR PMC9394213__F2 Roles and functions of SARS-CoV-2 proteins in host immune evasion TBK1 STAT2 IRF7 IRF9 IRF3 TYK2 JAK1 MAVS PMC9394213__F3 Roles and functions of SARS-CoV-2 proteins in host immune evasion STAT1 STAT2 IRF9 NUP98 IRF3 MAVS PMC5354945__F2 Therapeutic small-molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways CASP3 TRADD RELA TRAF3 RELB CD40 TRAF2 FADD MLKL PMC3917351__F4 Ca2+ transport remodelling in tumour vascularization TRPC4 TRPV4 TRPV2 TRPM6 TRPC6 TRPC3 TRPM2 TRPM7 PMC3917351__F3 Ca2+ transport remodelling in the promotion of cancer cell metastasis TRPV2 TRPV6 S100A4 TRPM7 TRPV1 TRPM8 PMC3917351__F2 Ca2+ transport remodelling in conferring apoptosis resistance in cancer cells TRPC4 TRPC1 TRPV6 ORAI1 STIM1 TRPV1 PMC3917351__F1 Ca2+ transport remodelling in promotion of cancer cell proliferation TRPC6 TRPC3 TRPV6 TRPM2 ORAI3 ORAI1 TRPM7 STIM1 TRPM8 PMC5813531__F3 Retrograde signaling during photooxidative stress in chloroplasts PC MAPK6 MAPK3 PMC4115292__F1 The one carbon (methyl group) metabolism in vivo HEL-S-182mP PMC3627223__F1 The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway BCR NFKB2 SYK PMC4590954__F5 Non-Smad signaling in response to TGFB1 and BMP-7 GRB2 TRAF6 BMP7 CDH2 MTOR PMC2912210__F1 Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response NF1 FOS EGFR MYC GRB2 PMC5571864__F1 Daily Rhythm in Plasma N-Acetyltryptamine ASMT TPH1 DDC TPH2 NAT1 NAT2 AANAT PMC7767853__F4 Interactions between picornavirus 2C protein and the NFKB and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) pathways IRF3 NOD2 MAVS PMC6211389__F3 Type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) on innate recognition of cytosolic nucleic acids TBK1 CGAS IRF7 IRF8 DDX41 IRF3 MAVS IFI16 PMC6211389__F2 Schematic view of Toll-like receptor (TLR)-mediated type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) TBK1 TLR9 IRF7 IRAK1 IRF8 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR7 TLR4 IRF-1 TIRAP PMC6581447__F2 Construction of the signaling network of cell migration regulators and their classification based on biological functions ADD1 IGF1R ALK TPM3 PAK4 DES RHO TRIP10 NRP2 PTS CORO1B CSNK1A1 GNAL ARHGAP5 IRF4 ABL2 IRGM APC CDH12 LAIR1 ABI2 ITGB8 DGKZ HEL113 ITGAV GFRA2 FRMD6 CDC42 AKT3 PMC3980263__F3 The LNG1 data set FHIT EGF CHUK EGFR GSK3B SMAD4 PORCN SENP2 DRD2 E2F3 CXXC4 BIRC3 SRC CASP9 ABCG2 NOS2 TUBB MAPK7 NR0B2 LRP6 ARHA PIK3R3 HMGCR NLK CACYBP NFKBIA CREBBP CDKN2B GRB2 ADCY6 BCL2 GNAS SKP2 CYCS PMC8898366__F9 PrPC Promotes Endometriosis Progression by Reprogramming Cholesterol Metabolism and Estrogen Biosynthesis of Endometrial Stromal Cells through PPARA Pathway ABCA1 NR1C1 HMGCR PMC3248195__F1 Elevated PI3K signaling drives multiple Breast Cancer subtypes TSC2 BAD TSC1 IGF1R IGFBP1 PTEN INPP4B IRS1 PMC4757520__F2 Signaling pathway alterations in Kupffer cells after alcohol and/or burn injury CD14 TLR4 LBP IRAK4 TNF PMC9526616__F7 Early Development of Cardiac Fibrosis in Young Old-Father Offspring TBX18 WT1 TCF21 PMC4526690__F3 Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation RPL11 MDM2 RPL5 PMC4017424__F1 NFKB signaling pathways TNF FADD PMC3896749__F9 Hypothesis for the development of tactile allodynia following nerve injury TLR4 IRF3 MYD88 TNF TIRAP PMC8490010__F3 From APC to the genetics of hereditary and familial colon cancer syndromes ZNRF3 ACVR1 RNF43 APC NTHL1 GPR49 PMS2 MLH3 ACVR2B ACVR2A BMPR1A STK11 MSH2 MUTYH OGG1 PCNA PMC8221416__F3 TLR signalling pathway TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR3 PMC8221416__F2 NLR signalling pathway NOD1 NLRP1 JUN IL1B NOD2 PMC4017424__F4 Activation of IKK pathway GRB2 SRC PTEN MTOR PMC5302996__F1 LncRNAs in pancreatic cancer HMGA2 NUF2 SOX2 GDF15 WDR5 CCND1 CDK4 AURKA CDK6 PMC10473144__F3 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease APC GSK3B LRP5 LRP6 PMC10473144__F2 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease APC GSK3B LRP5 LRP6 DKK1 PMC8883733__F2 Mucor circinelloides: a model organism for oleaginous fungi and its potential applications in bioactive lipid production CIT IPP MAL HEL-S-5 PMC6240607__F4 Schematic depiction of GDNF/RET/GFRA1 signaling in the ureteric bud (UB) tip during kidney development RET ETV4 GDNF SPRY1 ETV5 PMC9455009__F1 Programmed Necrosis in Colorectal Cancer GPX4 TRADD GZMA TNF TRAF2 FADD PMC11870059__F8 Metabolic pathway reconstruction graphs of the starch, nitrogen, and lipid in the rumen of sheep fed different forage and grain sources HIST1H1E H1-1 H1-0 H1-3 H1-2 H1-5 PMC4271074__F8 OAA effects and inter-effect relationships CCL11 NRF1 MTOR PMC10452754__F2 The molecular interaction between HLA-G and decidual NK cells at the maternal–fetal interface COX2 HLA-G PTN PDK2 PBX1 KIR2DL4 PMC6830889__F1 Main TLR-mediated signaling pathways triggered upon stimulation by LPS and LPG RAB8A TRAF3 TRAF6 IRF3 MYD88 MTOR TLR1 NLRP3 TLR4 LBP SYK IL1B TIRAP PMC8932105__F7 Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway SOX2 STAT3 PMC9179504__F1 Small Extracellular Vesicles: Key Forces Mediating the Development and Metastasis of Colorectal Cancer CXCL13 GMDS CXCR4 PTEN S100A9 STAT3 PMC6527583__F4 Acute phase response network: The acute phase response was the most-significantly represented pathway common to all CAPN5-NIV stages FGA HRG C4B_2 AMBP C4A ORM1 HEL-S-78p HEL111 C9 F2 RBP4 IL6ST INF2 C1S APOH TF PMC5711380__F7 Schematic summary of the IL-1B–IL-1 receptor signaling cascades identified in decidualizing human ESCs IL16 NFKB1 RELB MTOR PMC9489753__F2 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells CCR2 WNT3A CX3CR1 CX3CL1 VEGFA CCL2 IL1B STAT3 PMC9489753__F1 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells HGF LTBR FGF7 FGF9 PMC7695717__F6 Oxytocin signalling network enriched in the analysis of the interaction of diet and n-3 PUFA supplementation in pregnant heifers COX2 OMP ARHH DAO OXT COMP ELL PMC4269339__F2 Signal transducer and activator of transcription 3 (STAT3) pathways involved in immune escape STAT1 EGF TAP2 EGFR IFNG STAT3 PMC6016836__F3 Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection PRKCI EGFR HBEGF CRKL GNG12 PAK1 PFN3 ITGAE GRB2 SRC GNAL ACTR3 CDC42 PMC3272142__F4 Signaling pathways promoting trophoblast invasion and migration GSK3B RHO MTOR PMC5794834__F1 Complement amplification loop C9 CFB CFD C7 C6 PMC7069124__F4 Overlaying the consensus TLR4 signaling pathway in databases with HemeKG (A: original overlaid network, B: overlaid network after inclusion of literature evidence for effectors) IKBKG CHUK MAP2 MAPK8 MAP2K4 IRAK1 IRAK2 TRAF3 CXCL8 TRAF6 IRAK4 MYD88 MAP2K3 TLR4 INPP5D MAPK1 IL1B MAP6 CXCL11 CD14 IRF7 CXCL10 IRF3 IL6 TNF MAP3K7IP1 IKBKB NFKBIA MAP2K1 CXCL9 CD40 CD80 IRAK3 TIRAP TAB3 PMC7069124__F3 Consensus around the TLR4 signaling pathway in three major pathway databases CHUK TLR4 MAPK4 MAP2K3 TIRAP PMC5842404__F4 AMP‐dependent protein kinase (AMPK) signalling pathway INA EP300 LPO PMC5842404__F3 B cell receptor (BCR) signalling pathway ITGAM BTK AFP BCL10 DAO BASH LYN SYK ASAP2 BLK SP100 PMC8145847__F3 Hepatitis C Virus Uses Host Lipids to Its Own Advantage CLDN1 LDLR CD81 PMC8308767__F4 Phytomedicines Targeting Cancer Stem Cells: Therapeutic Opportunities and Prospects for Pharmaceutical Development SHH SMO RB1 PMC9165556__F1 Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease ATG16L1 MAPK8 IMPACT MAPK14 RIPK2 NOD2 NLRP3 BIRC2 CARD9 IL18 BIRC3 PYCARD IL1B ITCH PMC3509712__F1 Signal transduction pathways used by superantigens and mediators IRF9 TRAF6 RHO TNF MTOR HEL-S-11 LCK ZAP70 GRB2 JAK1 IRF-1 FADD LAT PMC7961492__F1 Mechanisms and molecules involved in cholesterol metabolism and homeostasis and the regulatory effects of Non-encoding RNAs are depicted in a foam cell CDKN2B APOC2 LPL ACAT2 PMC9683098__F6 ECM-associated protein secretion and intracellular accumulation in dermal fibroblasts SMAD2 C7 PMC4177547__F1 PI3K/Akt/mTOR pathway and relative inhibitors in NHL TSC2 RICTOR TSC1 PTEN MTOR RHEB PMC3403008__F3 Regulation of TLS in replication-associated ICL repair REV1 FAN1 RAD18 PCNA PMC6584837__F1 PI3K/AKT and cell cycle signaling pathway model of NKTCL RICTOR FOXO3A PIK3AP1 CCND1 PTEN MTOR PMC6527025__F7 Apoptosis Signalling in T-Helper Cells During HIV Infection.HIV proteins are involved in apoptosis APAF1 CXCR4 BCL2 BAX PMC6527025__F6 UPR Signaling During Influenza A Virus Infection.Upon IAV infection, BiP is released from UPR proteins (e.g EDEM1 ATF4 EIF2A EDEM2 XBP1 PMC4546216__F5 Scheme of the phenylpropanoid pathway FH CAD CCR1 PMC6527025__F5 Apoptosis Signaling During Influenza A Virus Infection.IAV infection affects apoptosis in early and late infection BAD RNF43 IL1B CLU BAX PMC3528279__F3 RIG-I/MAVS signaling pathway regulating hMPV-induced NFKB and IRF activation in airway epithelial cells TBK1 TANK IRF3 MAVS PMC3528279__F2 Toll-Like Receptors (TLR) signaling pathway involved in hMPV-induced gene expression in primary immune cells TBK1 CD14 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR7 TLR4 GIG8 RELA TIRAP PMC7885587__F6 Pathway analysis EGF LIMK1 IGF1R NR3A2 ID4 PGR EGFR WNT1 TGFBR2 VEGFA MYC MAP3K7 AKR1C1 MAP2K3 MTOR RHEB IGF1 WNT4 ERBB2 SRC NCOA1 TGFB1 PMC6527025__F2 Apoptosis Signaling During Arbovirus Infection.Arboviruses exert their effect on apoptosis through different signaling routes BAD TRADD EIF2A FADD HRK PMC6527025__F1 The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections ATG12 IRF3 DKFZp686F0183 MAVS PMC3542934__F1 TGFB signalling pathway SMAD2 TGFBR1 TGFBR2 FBN1 SMAD4 ARHA PMC8927915__F1 Teaching cancer imaging in the era of precision medicine: Looking at the big picture EGF APC EGFR PMC6764500__F3 Significant metabolic pathways, Ubiquitin‐mediated proteolysis pathway and Adherens junction and Wnt signaling pathway for regulated genes associated with IS‐SM when compared to IS‐NSM TERF2 LEF1 MID1 DAO ADSL C1GALT1C1 SLC33A1 AOC2 CCNC GCNT4 BRCA1 GLS PMC4826512__F3 Targeting of the Wnt/Beta-catenin signaling pathway by Tat altered miRNAs NLK MMP7 PIN1 HEL-S-28 MDM2 SRC DKK1 HDAC1 TCF4 PMC6689752__F1 Regulatory effects of micro-RNAs (miR) on specific stages of neuronal development LIMK1 PUM2 PTBP1 PMC4826512__F4 Targeting of the axonal guidance signaling by Tat altered miRNA RHOD FYN CXCR4 FES FARP2 EIF4E RND1 CDCA2 SDC2 CRK PXN PMC2679127__F2 PRRs and their corresponding ligands TLR5 TLR7 TLR9 TRAF6 MYD88 TLR1 TLR10 NOD2 TLR3 PMC7193471__F8 Signaling model of the IL6R-ADAR1-STAT3 interplay in multiple myeloma BCL2 IL6 MCL1 IL6R STAT3 PMC9153132__F2 Intratumor microbiome in cancer progression: current developments, challenges and future trends AHR FAP TIGIT PMC5357760__F2 Epidermal growth factor receptor (EGFR)–related signaling pathway in metastatic colorectal cancer EGFR PIK3CA MTOR PMC9424811__F2 RING finger protein family in health and disease TLR9 RNF31 RNF182 TRAF3 RNF19A RNF152 TRAF6 IRF3 MYD88 RNF41 TLR3 RNF170 TLR7 TLR4 RNF114 RNF121 RNF128 RNF115 RNF166 PMC9548363__F8 Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway TLR4 CCL2 IL1B PMC9424811__F4 RING finger protein family in health and disease TBK1 CGAS RNF5 RNF26 RNF185 RNF114 IRF3 RNF128 RNF111 RNF115 PMC7262792__F3 Possible mechanisms for growth hormone (GH) deficiency in children with mosaic gain-of-function mutations in the PI3K-AKT-MTOR pathway: IGF1R IGF1 MTOR GHRH PMC9424811__F3 RING finger protein family in health and disease TBK1 RNF123 RNF11 RNF122 TRAF3 IRF3 RNF125 RNF19B RNF5 RIPK1 RNF114 RNF121 RNF128 RNF34 MAVS RNF115 PMC8757826__F2 Oral Cancer Stem Cells: Therapeutic Implications and Challenges EGF SOX2 SMAD2 PTCH1 EGFR CD44 HEL-S-53e SMO BMI1 CD24 PMC9424811__F5 RING finger protein family in health and disease IFIT3 STAT2 RNF31 IRF9 RNF213 RNF2 IFNAR2 IFNAR1 STAT1 ISG15 RNF19B RNF168 TYK2 JAK1 RNF220 RNF115 PMC5579609__F3 PC-DHA levels depend on nutrition, liver and brain synthesis by PEMT and transport of LPC-DHA across the blood-brain barrier catalyzed by MFSD2A HEL-S-61p MTR PEMT PMC5974170__F3 Lipid droplets and the immune response during protozoan infection ICE2 IRGM GC PMC5090835__F1 Anesthesia-induced pathways of neuronal apoptosis.Anesthesia induces apoptosis by seven different pathways BDNF PMC2948618__F3 3rd US-EU Workshop Systems level understanding of DNA damage responses ATM CDC25B ATR PMC2832236__F5 BS and M chloroplast distribution of proteins involved in primary carbon metabolism HEL-S-62p PGM2 PGP GIP RPE HEL-S-68p PMC7215321__F3 Necroptotic signaling pathway exemplified by tumor necrosis factor alpha (TNFA)-mediated activation of tumor necrosis factor receptor (TNFR)1 RIPK1 TRADD CYLD RIPK3 FADD MLKL PMC6142519__F3 Aberrations in the Ras signaling pathway that lead to excessive proliferation NF1 GAB2 GRB2 CBL PMC2830120__F3 Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection FYN STAT3 PMC5501852__F6 Interaction network of cancer cells and their microenvironment associated with the EMT process EGF SNAI1 HGF RUNX1T1 EGFR SMAD2 GSK3B SMAD4 SERPINB5 WAS MTOR DCN TLR4 PDGFA SRC SHH KITLG CRB3 SFRP1 SMO PARD6A CAV2 ARHGAP5 JUN PTPRM KIT BMPER IGF2 SMAD6 BMP7 ARHA TNF LTBP1 CRK FUS PTPRF THBS2 TWIST1 ERBB2 SMURF2 PTCH1 TM4SF4 TGFA TGFB1 INHBA CDC42 STAT3 PMC3862457__F1 Signaling pathways that modulate amino acid, insulin/IGF-I, and resistance exercise–induced activation of mTORC1 signaling TSC2 NPRL2 TSC1 DEPDC5 WDR59 SEH1L MIOS TBC1D7 WDR24 RHEB MLST8 PMC7463266__F9 Illustration of this study’s results and a working model RUNX2 ATOH8 SMAD1 DKFZp781O1323 PMC9460414__F1 Plant-Derived (Poly)phenols and Their Metabolic Outcomes: The Pursuit of a Role for the Gut Microbiota MBP DBP INS PMC7377092__F1 ERK signaling EGF WEE1 ATM CCND1 ERCC1 BNIP3 ATR PMC8374228__F3 Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge BCR BACH2 APC LRBA CD80 STAT5B FADD STAT3 FOXP3 PMC11937136__F6 Proposed mechanism for reproductive damage induced by ICIs through testicular inflammation, oxidative stress, and ferroptosis, as well as the protective role of RSV against ICIs-induced reproductive toxicity COX2 GPX4 FACL4 KEAP1 SLC7A11 SLC3A2 NQO1 PMC12140338__S1 Potential mechanism by which viridicatol (VDC), derived from deep‐sea fungus, enhances osteoblastogenesis through modulation of the Wnt/SHN3 signaling pathway ALPL RUNX2 APC GSK3B IBSP SP7 BGLAP PMC4314728__F9 Schematic of the signaling pathways activated by the P2Y2R in endothelial cells that are thought to regulate vascular permeability RAC1 GAA VAV2 PMC4405894__F3 Pathway of all possible EGFR family dimer combinations showing various growth factors known to activate EGFR family and all possible dimer combinations EGF ERBB4 ERBB2 ERBB3 EGFR SRC MTOR TGFA STAT3 PMC5295437__F8 Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway TSC2 TSC1 RHEB PMC5594916__F6 Schematic illustration shows targeting of the hnRNPA1/pri-miRNA-18*/K-RAS pathway by miR-25-3p and miR-15a-5p DGCR8 DROSHA PMC4270387__F1 Examples of non-stress-related peroxide signaling EGF CS CYP11A1 LPA HIF1A PRX STAR PMC10669195__F1 Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling MAF CDH6 KEAP1 RBX1 RXRA PMC6682991__F1 Representation of the various selenium metabolic pathways leading to selenoprotein synthesis GPX4 SELENON TXNRD2 SELENOT SELENOP SELENOW SELENOH SEPHS2 GPX1 SELENOF SELENOI SELENOO SELENOV GPX6 SELENOM SELENOK GPX3 GPX2 DIO1 SELS PMC2879321__F1 Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis EGR1 KY EGFR GRB2 SRC MYD88 PMC11945442__F11 Proposed mechanism by which ACA affects the TNF-Alpha-induced NFKB pathway and ICAM-1 expression RIPK1 TRADD TRAF2 PMC6494926__F1 Granulin biogenesis, quality control at the ribosome during its synthesis, and molecular mechanism of FTLD associated with mutations in the signal peptide of the granulin precursor M6PR PSAP GRN PMC6533287__F5 Human mTOR pathway INS TBC1D7 PTEN RHO EIF4E MTOR DEPTOR IRS1 RHEB TSC2 RICTOR TSC1 GRB2 GRB10 SGK1 PMC8568331__F2 Targeting cyclin-dependent kinase 4/6 as a therapeutic approach for mucosal melanoma NF1 KIT BRAF MAP3K11 RASA2 EGFR NRAS CCND1 PTEN RB1 HRAS PMC1781062__F1 CCM2 as a Scaffold for p38 MAPK Activation MAPKAPK2 MAP2K4 MAPKAPK5 MAP2K3 MAP2K6 PMC6104565__F5 Pharmacological targets of ErbB2 signaling pathway in Her2-enriched subtype EGF NRG3 BAD NRG2 MYC SHE HBEGF MTOR CRK CBL BTC GRB2 NRG4 JUN PMC4786834__F1 Linkage between the mechanisms of thrombocytopenia and thrombopoiesis FLI1 TPO MPL KLF1 PMC4122595__F2 AB oligomers activate several ‘stress-response’ kinase pathways in neurons TSC2 TSC1 MTOR IAPP CAMKK2 PMC2784807__F5 Ingenuity Pathway Analysis® network depicting relationships among genes involved in immune and metabolic responses due to IMI with Streptococcus uberis CD14 PLAUR SCD LPIN1 FOS LPL HEL-S-44 SELP HEL110 GPAM CD36 PMC10728021__F5 Proposed combination treatment strategy to tackle p53‐mutant esophageal squamous cell carcinoma (ESCC) tumors with a WEE1 inhibitor WEE1 ATM CDC2 ATR PMC2784807__F3 Cyclin-dependent kinase (CDK) 5 (A) and Insulin-like growth factor (IGF)-1 signaling pathways (B) among 2,102 differentially expressed genes due to intramammary infection with Streptococcus uberis PAK1 IGF1R IGF1 NGF APP LPP ATR PIGL PMC2784807__F1 IL-10 and IL-6 signaling pathways among 2,102 DEG due to IMI with Streptococcus uberis TH SHE CP STAT3 PMC9376115__F5 Regulated cell death (RCD) in cancer: key pathways and targeted therapies NLRP3 NLRC4 NLRP1 GSDMC AIM2 GSDMB GSDMD PMC3260452__F2 Simplified model of the leptin signaling pathway PC NPY AgRP MC4R TRH MC3R BDNF PMC9376115__F6 Regulated cell death (RCD) in cancer: key pathways and targeted therapies GPX4 LPCAT3 FACL4 KEAP1 ATF3 POR BAP1 PMC4251064__F2 Dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) TP63 TP73 SIN3A HDAC1 PMC4251064__F4 Canonical pathway of TP53 signaling: dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) TIGAR PML PERP DKFZp781B1423 TOPBP1 GML MDM2 PTEN SDK2 ATR PMC12195631__F8 Regulatory mechanism of BB in the treatment of CAG CDH2 MTOR PMC9376115__F3 Regulated cell death (RCD) in cancer: key pathways and targeted therapies PINK1 ULK1 ATG3 AMBRA1 ATG101 ATG14 PMC9376115__F2 Regulated cell death (RCD) in cancer: key pathways and targeted therapies TRADD TRAF2 FADD STAT3 BAX PMC11275360__F6 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation FOXO3A MTOR PMC5674931__F5 The role of metabolism and microRNA (miRNA) in daunorubicin and cytarabine treatment CYP3A4 PMC11275360__F5 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation MOS RUNX1 SRC PMC5674931__F4 The interactions between microRNAs (miRNAs) and cell death-related proteins in drug resistant cells BAK1 BCL2 DKFZp686F0183 PMC11275360__F4 lncRNA regulates adipocyte differentiation through TGFB/BMPs/Smad signaling pathway BMP7 GDF11 BMP4 PMC11275360__F3 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation APC DVL3 PMC6929101__F3 TGFB activation in the tumor microenvironment MSC IL11 CXCL12 PMC6929101__F2 TGFB alteration in colorectal cancer (CRC) cells VEGFC CXCL1 VEGFA IL8RB RHO IFNG PMC10483926__F7 Illustration of a hypothetical model in which TgESPs regulate aerobic glycolysis to promote osteogenic differentiation through the Wnt/Beta-catenin signaling pathway LEF1 RUNX2 LRP5 LRP6 HEL-S-133P HK2 PMC6929101__F1 Schematic representation of Transforming growth factor-beta (TGFB) superfamily signaling pathway SMAD2 SMAD4 RHO SMAD1 DKFZp781O1323 PMC5345933__F2A Cell cycle proteins as promising targets in cancer therapy CCNA2 ATM FOXO3A CDK2 F3 DHFR MYC SMAD4 GSK3A C6 CDK4 FOXO1 PMC4429713__F1 Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway ATM ATR EED PMC8068500__F2 Bioengineering strategies to control epithelial-to-mesenchymal transition for studies of cardiac development and disease WT1 PMC8079716__F2 From purines to purinergic signalling: molecular functions and human diseases PAICS HEL-S-70p PMC4258159__F5 The PI3K/mTOR signaling pathway upon stimulation with growth factors, with an emphasis on the phosphoregulation of PRAS40 TSC2 TSC1 EIF4E MTOR DEPTOR EIF4B IRS1 RHEB PMC5961053__F1 Production, elimination, and signaling of ROS HEL-S-44 PRX PMC9489683__F5 Maintaining the regulatory T cell program during inflammation: a delicate balance GIG8 TET3 STUB1 IL33 NFIL3 TIGIT EZH2 USP44 IL1B ICOS TET2 FOXP3 PMC9489683__F3 Treg suppression of conventional T cells HPGD AHR NRP1 APC CD80 TIGIT LAG3 FGL2 STAT3 PMC9028246__F4 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer AMOT EGFR SRC TNKS LATS1 RHO MOB1A PMC4357373__F11 Identification of microRNAs and their target genes in Alport syndrome using deep sequencing of iPSCs samples OMP TES ADA PMC9028246__F2 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer WWC1 AMOT NF2 SRC AJUBA LATS1 RHO MOB1A FAT1 FRMD6 TAOK1 PMC9028246__F1 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer LATS1 MOB1A PMC11632667__F3 1) BMPs activates the SMAD pathway, which increases inflammatory cytokines VEGF, tumor necrosis factor alpha (TNFA), and Interleukin-6 (IL-6) MSC SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC7661081__F1 MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 PMC3901996__F2 Transmembrane signaling of IL-6, which is a major growth factor for MM STAT1 GRB2 SOS1 STAT3 PMC8175905__F5 Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma MTOR PMC3287579__F1 Adapted from PC RAC1 PMC9010499__F2 Intratumoral cancer immunotherapy exploiting anti-viral immunity TBK1 CGAS TLR7 TLR9 IRF7 IRF3 MYD88 TLR3 PMC3730324__F1 HIFs are involved in crucial aspects of tumor progression and metastasis in sarcomas IGF2 VHL ABCB1 PMC9641156__F3 Novel insight into the functions of N6-methyladenosine modified lncRNAs in cancers (Review) YTHDF1 PC METTL3 GC PMC11955304__F5 STAT3 signaling pathway can be targeted using various therapeutic agents SRC CPA1 STAT3 PMC11955304__F3 STAT3 Signaling Pathway in Health and Disease SOCS3 SRC IL11 IL6 STAT3 PMC5529905__F1 Signaling pathway resulting in TNFAlpha-mediated necroptosis, and specific necroptotic inhibitors targeting RIP1 and MLKL TRADD TRAF2 FADD MLKL PMC9028270__F2 Regulatory Processes of the Canonical Wnt/Beta-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair APC GSK3B PMC5670164__F2 Non-canonical activation of the sonic hedgehog (Shh) pathway SUFU SHH SMO PTEN PMC4341198__F8 Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems H2AX BAX PMC5670164__F1 Sonic hedgehog (Shh) signaling pathway in a mammalian system HHIP DHH IHH KIF3A SHH SMO PMC4041829__F1 Overview of cellular Na+ transport mechanisms and important components of the salt stress response network in plant root cells MYB SOS2 ERF PMC4247580__F10 Arabidopsis Lipins, PDAT1 Acyltransferase, and SDP1 Triacylglycerol Lipase Synergistically Direct Fatty Acids toward Beta-Oxidation, Thereby Maintaining Membrane Lipid Homeostasis PC LPL PMC8662819__F1 Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer LAG3 PDCD1 PMC5670164__F3 Regulation of thyroid cancer stem cell (CSC) self-renewal by the sonic hedgehog (Shh) pathway KLF4 SHH SMO BMI1 LIN28A MTOR CSF1 PMC5822876__F6 Rheumatoid Arthritis-related molecular signaling pathway ATF2 CCL5 PMC3355898__F2 Somatic alterations in the PI3K pathway in prostate cancer PIK3R1 PIK3CA PTEN INPP4B PIK3R3 PMC6476484__F1 Biological functions of IL-32 in inflammatory tumors MMP2 MMP9 CCL21 CXCL2 PMC7769460__F6 The MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer TH PEAR1 EPCAM OMP CDK19 OR2B2 TFDP2 OR7E24 ADAM17 KNSTRN BMPR2 TLR4 SCD KNTC2 LAMC2 KIT PLAUR AREG CD44 HBEGF HMGCS1 CD164 CENPK CRK CCBE1 CDC20 INSIG1 MAX BIK PMC8467271__F3 Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery USP4 USP15 OTUD1 SMURF2 USP9X SMAD4 TBR1 HEL-117 TRAF4 PMC1773546__F3 The key proinflammatory pathway induced by enteric pathogens results in nuclear factor kappa B (NFKB) mediated transcription of interleukin 8 (IL-8) TLR5 TRAF6 MYD88 ARF6 TRAF2 PMC7794175__F1 Genomic alterations in the cyclin pathway in patients with cancer CDKN1A CDKN2B CDKN2C CDKN1B CCND1 CDK4 RB1 CCND3 CDKN2A CDK6 CCND2 PMC3627353__F2 Genes and signaling pathways involved in ureteric budding FOXC1 RET EYA1 PAX2 SALL1 GDNF ROBO2 SIX1 SLIT2 FOXC2 GATA3 BMP4 PMC8582360__F2 HGF/MET Signaling in Metastatic Uveal Melanoma HGF GRB2 SRC RAC1 MTOR STAT3 PMC6533683__F10 Regulating EMT by targeting autophagy HMGB1 HEL-S-28 PMC2681266__F1 NFKB activation in cancer RELA EGFR LTB PMC6656421__F8 IPA Network RAB5B INS CYP11A1 GATA6 HSD3B2 LHCGR KIAA1608 LHB CYP17A1 INSR PMC4493903__F1 LIF is a new p53 negative regulator LIF MDM2 ID1 STAT3 PMC6640532__F1 Ubiquitin/26S proteasome system (UPS) RPN2 SKP1 RBX1 PMC7504089__F7 Differential gene expression in apoptosis and death receptor signaling pathway in ‘ECACC vs IKBKG CHUK BAD NGF TRADD MAP2K4 CASP2 RIPK1 TNFSF6 DFFB DFFA APAF1 BIRC3 FOSB APP TNFSF12 JUN ARHGDIB BAX FOS TNF CASP10 DIABLO HTRA2 GAS2 IKBKB BIRC2 NFKBIB TNFSF10 TNFRSF1A ERN1 BCL2 CRADD TRAF2 FADD CYCS PMC3499997__F2 Main therapeutic targets along the BCR signaling pathway in CLL cells BTK BCR BASH CD22 LYN SYK PLCG2 PTPN22 PMC3593794__F6 CDK5 phosphorylation substrates during neuronal migration LIMK1 CDKN1B CDK5 HEL-S-15 CDK5R1 ARHA NDEL1 PMC9450390__F2 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy HMGB1 TBK1 CGAS GSK3B SSB CXCL8 IRF3 MYD88 IFNG STAT1 TLR4 CXCL9 IRF-1 MAVS STAT3 PMC9450390__F1 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy GZMA SSB PRF1 PMC3627353__F3 Genes and signaling pathways involved in ureter development KIT TBX18 TSHZ3 AGTR1 HCN3 SHH SMO BMP4 PMC9471952__F2 Neuregulin-1, a potential therapeutic target for cardiac repair NLRP3 ERBB4 ERBB2 AREG ERBB3 EGFR GSK3B NRG1 PMC2603427__F5 Hierarchical layout of the EGFR1 pathway downloaded from the HPRD pathway database PLSCR1 PLCG1 PRKCZ SMAD2 MYC TNK2 CRK STAT5B CEACAM1 PRKCA PRKCB PLD2 SH3GL2 GRB2 SRC CTNND1 CASP9 CAV2 RAF1 RGS16 JUN STAT3 PMC7199893__F4 FATE OF ALT-INHIBITED CANCER CELLS PML BLM TOP3A SMC6 RAD52 FANCM SLX4IP RAD51AP1 ATR SMC5 TSPYL5 PMC9546849__F3 RNA m6A writer WTAP in diseases: structure, roles, and mechanisms EGF IRF3 WTAP WT1 IFNAR1 PMC8599985__F2 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function TLR4 EGFR CSF2 TNFAIP3 REG3A STAT3 FOXP3 PMC2603427__F6 Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database BRAF PPP3CA MAPK8 MAPK3 GSK3B MAPK14 TEC CREB1 PLCG2 RB1 CDK6 BTK FYN PIK3AP1 BASH PTK2B CASP9 MAPK1 CDK4 RPS6 HCLS1 NFATC1 GSK3A CD79B NFATC3 PRKD1 CBL BCL6 RPS6KB1 CARD11 NFATC2 PPP3R1 RPS6KA1 CDK2 CD22 SYK CSA2 SHC1 PTPN18 PIK3R2 PMC8599985__F1 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function EGF CXCR1 NGF FOS EGFR MYC IL8RB PTEN EIF4E IRS1 CRKL RHEB TSC2 TSC1 GRB2 IL7R SRC TYK2 KLF2 JAK1 JUN PMC6332659__F3 Tissue-specific gene regulatory network of the top KDs in psoriasis HLA-E TNFRSF14 CTSS CD6 MYC FITM2 THYN1 CD74 HSDL1 IL16 CSF1R IL10RA LTB VEGFA RAB31 CTSH CYBB HLA-DRB1 HLA-C HLA-F IL15 HLA-A TIMP1 CD27 NFKB2 TRAF1 GRB2 HEL113 TNFAIP3 PSMD1 HEL-S-62p CHUK HLA-G BAD CD33 F2R TRADD EGFR CD48 HLA-DQB1 CD81 IL18 IKZF1 BBS4 BIRC3 CD2 GZMA IFI30 IL1B CD3E CLTB CD14 YBX1 PLEKHO2 PS1TP5BP1 TAPBP CBL TNFRSF25 SELPLG NFKBIA TNFSF10 LCK GNL3 ZAP70 LYN C6 CCL18 MCL1 REL SRGN CYCS PMC7068214__F7 Investigation of the Genome-Wide Genetic and Epigenetic Networks for Drug Discovery Based on Systems Biology Approaches in Colorectal Cancer SPARC STK17B STAC RORB ARSF SLC16A5 ARMC8 TMEM39A GP5 CBLN1 AHR WNT4 VWF GDNF GNAL ANGEL2 MAFG PTK6 ENPP4 STOM STAP2 MUC2 PPP2R3B ANP32E WDR4 GRID2 SMC2 PMC9546849__F6 Other functions of WTAP in cancers MUC1 MMP7 APC EGFR GSK3B WTAP WT1 MMP28 CA4 BCL6 PMC6826908__F1 Canonical Wnt signaling pathway ZNRF3 RNF43 APC GPR49 PMC2361115__F1 Cytoplasmic/traditional and nuclear modes of the EGFR signalling pathway EGF EGFR CCND1 STAT3 PMC4847613__F6 Regulation of trophectoderm (TE) lineage specification by mevalonate pathway CDX2 TEAD4 RHO GATA3 HMGCR PMC5458287__F1 Targeting HOX/PBX dimers in cancer CASP3 EGFR ATF3 CASP8 BAX PMC8801368__F1 Progesterone Receptors in Breast Cancer WNT4 CXCR4 CXCL12 PMC5356509__F2 Intrinsic and extrinsic apoptotic pathways, the TRADD/NFKB survival pathway, and the growth factor (GF) receptors PI3K/AKT pro-survival signaling axis in CSCs BAD TRADD FADD BAX PMC9225081__F2 Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice RAD51 RAD18 PCNA PMC6523766__F2 Metabolic reprogramming in RCC FH HEL-S-133P HEL-S-68p SDHB HEL-S-162eP GLS PMC6523766__F1 Genetic mutations, HIF-1A activation and metabolism of RCC TGFA HEL-S-133P ELL PMC7226520__F3 Adipocytokine signaling pathway in humans (KEGG hsa04920) LEP SOCS3 TRADD NPY AgRP LEPR TNF MTOR TRAF2 NR1C1 STAT3 PMC5486005__F1 Key miRNAs in the resistance to BC treatment PTEN MTOR STAT3 PMC5831670__F4 Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer’s Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses HMGB1 IL6 PMC7226520__F7 Comparative downstream pathway analysis of the effect of the adipocytokine pathway in breast cancer using the SEanalysis web tool for super enhancer associated regulatory analysis CITED4 PCP4 IER3 MLPH C9orf50 AMOTL2 PARD6B EDN2 KRT18 TRAF4 ZMYND8 PMC5642638__F2 Role of PLZF as a tumor suppressor in prostate cancer EGF KLK4 BRAF FOXO3A PBX1 PMC7774091__F8 Proposed apoptotic pathway for the anticancer compound, SYA013 BCL2 MCL1 PAF1 BAX PMC6162242__F8 A schematic for an miR-532-5p/KRAS-NAP1L1/P-ERK/ETS1 feedback loop PMC9654658__F1 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response IL10 TH IL15 COIL TNF TGFB1 IFNG PMC8897182__F2 Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension BMPR2 TGFBR1 LDLR PAH GLA PMC6776600__F11 Complement inhibitors target different levels and steps of the complement cascade HEL-S-62p MASP2 CP PMC9654658__F3 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response MOS ASPH ARC PMC8416576__F4 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis SPARC EGF APOA4 PLG HEL-S-84 A1BG VEGFA PRKCSH AMBP HEL-S-125m RBP4 SERPINA1 TGFB1 PMC6250919__F1 Genetic polymorphisms more consistently associated with non-alcoholic fatty liver disease and their suggested physiopathological role PNPLA3 TM6SF2 GCKR MBOAT7 PMC8416576__F5 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis HEL-S-89n HEL-S-30 GANAB EEF1A1 BCL2L1 HSPD1 HEL-S-7 HYOU1 HEL-S-32 MDH2 HEL-S-102 CCT8 PSMC6 ACO2 PMC8343402__F5 Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants PLK1 MAPK3 MYC NAPB TAOK1 PSMD13 NF1 POLE GOLIM4 PREB PSMD10 PSMA8 SPTBN1 B9D1 NOTCH1 SHH HEL-S-44 EZH2 GCLC COG2 RPN2 RPN1 HEL-S-276 NAPG HEL-S-72p AMT PSMD9 NPHP1 CC2D2A XBP1 AFF4 RRM1 RRM2 DYNC1LI2 DCTN1 PSMB8 HEL-S-89n NOTCH4 RBPJ STXBP1 VHL EP300 NCAPG TCTN3 TUBB4A PSMB10 KDELR3 GPX4 HSPA2 PSMB3 PRIM1 GOSR2 GOSR1 B4GALT2 KNTC1 COG5 PSMB9 GGCT MAN1A2 FOS DPAGT1 MAN2A2 ATF3 MAN2A1 BARD1 MCM7 MGAT1 FOXO1 AURKB CDC45 MCM3 DPM1 TUBA1A MCM6 STT3A MCM2 HEL-S-64p PPP2R5B SIRT1 DYNC1H1 COG8 COG1 OPTN LIMD1 KIF11 SEC31A CDC2 JUN PCM1 STX6 FOXO3A HIF3A CHEK1 NAPA CENPP HEL-S-102 PSMB6 NFKB1 SMC2 STT3B PMC4490948__F2 IRE1–RIDD–RIG-I pathway TRAF2 XBP1 MAVS PMC4357785__F6 Important pathways in HCC Shown is the mTOR/AKP/PIP3 pathway that contributes to transformation of nodules into metastatic counterparts BAD GHR RHO RAF1 MTOR CRB2 PMC9679411__F6 Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients CXCL10 PMC5330314__F7 High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity HEL-S-62p IL1B PMC3593794__F3 PAFAH1B1 (platelet-activating factor acetylhydrolase 1 regulatory subnuit 1, formerly known as LIS1)-binding partners PAFAH1B1 IQGAP1 HEL-S-303 RAC1 NUDC DAB1 NDEL1 NDE1 CDC42 PMC6911354__F1 MYC as master regulator of proliferative lipid metabolic pathways: fatty acid synthesis, fatty acid elongation, and glycerophospholipid synthesis CDS1 SCD ACACA MYC ELOVL6 LPA ACLY ELOVL2 FASN PMC7076845__F7 Modulating NF-kappa B signaling pathway of DHI against UA EGF NGF TRADD TRAF3 TRAF6 PLCG2 MYD88 COX2 GADD45B BTK BCR ATM BASH CYLD IL1B CD14 LTB TRIM25 CNTF EDARADD EDAR LTA TRAF5 TRAF1 LCK LBP LYN SYK TRAF2 LTBR LAT TIRAP PMC10584331__F2 Reverse of liver fibrosis by inducing ferroptosis by bioactivated compounds in HSCs FGF21 GPX4 ZFP36 HEL-S-64p HEL-75 TF BAP1 PMC7216212__F3 Dichotomic Role of Macrophage Migration Inhibitory Factor in Neurodegeneration HDAC3 GFAP PMC10584331__F1 Ferroptosis mechanisms GPX4 LPCAT3 ADA HEL-75 PMC2835321__F6 Retrograde mechanisms in NMJ formation RET GDNF PMC3069769__F1 Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy TSC2 TSC1 MAPK3 MAPK1 PTEN EIF4E DEPTOR IRS1 SGK1 RHEB PMC7297083__F2 Interaction between pattern recognition receptors (PRRs) from dendritic cells (DCs) and VLPs FER CD80 PMC4398389__F1 Unraveling the Molecular Signatures of Oxidative Phosphorylation to Cope with the Nutritionally Changing Metabolic Capabilities of Liver and Muscle Tissues in Farmed Fish ATP8 UQCRFS1 ATPAF2 NDUFV3 ZNF183 NDUFB8 NDUFA12 UQCRC1 OSCP1 NDUFA9 NDUFA11 SURF1 UQCR10 COX7C SDHD SDHA SDHB UQCRQ NDUFS4 SDHC SDHAF1 NDUFAF2 NDUFB9 ATP6 NDUFA6 UQCRC2 NDUFC2 NDUFB7 NDUFB3 COXFA4L2 SDHAF2 UQCRB NDUFA13 NDUFB10 COX6A1 NDUFS5 NDUFB6 NDUFB5 NDUFB11 NDUFS6 NDUFV2 NDUFA7 NDUFB2 NDUFS3 COXFA4 ND6 NDUFA2 NDUFB4 NDUFB1 ND1 ND2 UQCRH NDUFA3 CYC1 NDUFC1 NDUFA10 PMC6937732__F8 Schematic model depicting the promotion of esophageal squamous cell carcinoma (ESCC) cell metastasis GSK3B SRC STAT3 PMC4284611__F7 A model of enhanced cancer invasiveness and proliferation elicited by adjacent fibroblasts TSPAN12 CXCL6 PMC9315629__F5 Circular RNA in Brain Tumor Development CD44 VEGFA FBXW7 WWOX ITCH AKT3 PMC7762545__F3 The conventional Kyoto Encyclopedia of Genes and (KEGG)-determined ccRCC pathway in the three cancer nodules with respect to the normal tissue from the right kidney CREBBP EGLN3 EP300 VHL VEGFA HIF1A RBX1 EGLN2 TGFA EGLN1 ARNT2 PMC6332805__F3 Selective Autophagy degrades cell cycle proteins STUB1 CDK2 VHL CCND1 RAD51 CDC2 CHEK1 PMC6332805__F2 Different types of autophagy ATG12 ATG14 DKFZp686F0183 PMC9315629__F4 Circular RNA in Brain Tumor Development ABCC3 MMP2 FOXO3A FOXM1 RFX3 FLNA VEGFA NUP98 ENTPD7 SKA3 CDC45 PMC9315629__F3 Circular RNA in Brain Tumor Development CFH MMP9 ZNF292 SHKBP1 PARP4 SOX4 PMC6177508__F1 Schematic model for phosphorylation-dependent YAP translocation by DVL LATS2 PMC6034857__F11 MAPK signaling pathway CD14 EGF MOS FLNA ATF2 GRB2 ECSIT RAF1 TNF TRAF2 JUN PMC7886700__F1 Growth factor mediated activation of AKT1 GSK3B PMC6034857__F10 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) ME1 BAD MEI1 EBP PTEN EIF4E MTOR IRS1 CLU RHEB RXRA TSC2 TSC1 BCR MDM2 SYK EIF4B RBL2 CD19 PMC2590699__F1 Current model for Okazaki fragment maturation FEN1 DNA2 PIF1 PMC3165799__F1 Schematic diagram of the ER stress response TSC1 ATF4 EIF2A RHEB PMC9116919__F2 Vascular Calcification in Chronic Kidney Disease: An Update and Perspective PTH1R TLR4 RUNX2 OGT LRP5 PTH MSX2 MYD88 MTOR SIRT1 SOX9 STAT3 PMC11361845__F5 Analysis of changes in the proteome and phosphoproteome according to DNK72 treatment in patient derived glioblastoma cells LRRK2 RHO GAL PMC10378680__F5 The Piezo1 Mechanosensitive Channel in Heart Failure IL10 CCR2 PIEZO1 IL6 TGFB1 IL1B PMC3175149__F1 IL-33 release and signaling via ST2L IRAK1 IL33 TRAF6 MYD88 PMC8835847__F8 microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells CXCR4 CD44 CD24 PMC4863577__F1 Hh pathway critical components which could be targeted by potential antibasal cell carcinoma drugs.Notes: The mechanism of action of each single drug is explained in the text SUFU EGFR SMO PMC8167111__F6 FGF2/MAST4/ERM pathway in SSC self-renewal BCL6B CXCL5 FGF2 CXCL12 PMC7753217__F2 IFITM3’s mode of action in cancer STAT1 IKZF1 STAT2 IFITM3 SMAD2 KLF4 SMAD4 MTOR STAT3 PMC12025613__F1 Key pathways involved in hepatocellular carcinoma metastasis GHB2 SMAD2 APC GLI3 TGFBR1 SMAD6 MTOR PMC6031408__F8 Schematic describing the proposed role of MYC and CDKN1A in Wnt/Beta-catenin (CTNNB1) and angiopoietin pathway-dependent hyaloid vessel regression CDKN1A LRP5 LRP6 WNT7B PMC3712086__F5 Diagram illustrating the signaling mechanism of how CARD9 may be inhibiting apoptosis from TNF-alpha CARD9 TRADD TRAF2 FADD PMC5863305__F1 Role of miR-146a in diabetic microvascular complications ERBB4 IRAK1 IRAK2 NOTCH1 TRAF6 CP STAT3 PMC3069839__F5 Regulation of Atm pathway genes after Rif-Phen-MCT CHEK2 ATM MDM2 TP73 CSA2 JUN BRCA1 PMC7142218__F1 FGF2 functions through FGFR dependent or independent pathways FGFR1 IRF7 FRS2 FGF2 GRB2 FGFR3 IRF3 FGFR4 FGFR2 MAVS PMC6345046__F5 Relationship between autophagy and cytokines TLR4 TRAF6 MTOR DKFZp686F0183 TLR3 GABARAP PMC3146511__F6 Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles MYB APC IL6 NFATC3 CDC45 KIF11 UBE2C NUF2 RRM2 KNTC2 MCM10 LARP1B DLGAP5 CENPA SPC25 PMC6814598__F1 Damaged nuclear DNA export, sensing and clearance in aging-related inflammation TBK1 CGAS IRF3 PMC8125157__F2 Cholinergic Modulation of Neuroinflammation: Focus on A7 Nicotinic Receptor SOCS3 STAT3 PMC6678477__F1 Rac1 activation is regulated by GEFs and GAP TIAM1 RAC1 SOS1 VAV2 PMC10380735__F1 Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death TRADD APAF1 FADD PMC3380518__F1 IL-33 signalling pathways IRAK1 SIGIRR IL33 IRAK4 MYD88 PMC7349525__F3 PD-related proteins and chaperones involved in proteostasis: Other well-characterized PD-related proteins, their cellular localization and functional pathways involved are depicted in this figure VPS35 PINK1 LRRK2 BAG2 CDC37 BAG5 BAG1 DNAJC6 PMC9170603__F3 MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers IL10 IL9 IL27 SRC IL11 IL6 IL-21 STAT3 PMC9570382__F1 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer FGF9 PMC9570382__F3 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer IGF2BP1 SMIM30 EZH2 PMC9570382__F2 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer MAP3K2 EPHA2 PBX3 PMC9292941__F3 Genome of a nonphotosynthetic diatom provides insights into the metabolic shift to heterotrophy and constraints on the loss of photosynthesis CS PC TNLG7C PMC7058049__F9 Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation RUNX2 TNFAIP3 PMC3980848__F1 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity DGCR8 DROSHA TRAF6 PTEN MTOR FOXO1 PTPN22 IFNG AGO2 DUSP5 TEF SOCS1 IL2RB PMC11539687__F2 This figure illustrates the neuroprotective mechanisms of GLP-1 receptor agonists (GLP-1RAs) in neurons and microglia, highlighting the key molecular pathways involved in neurodegeneration and inflammation NLRP3 MTOR TFAM BAX PMC9457923__F1 ABCC4 inhibition as a potential therapeutic strategy against SHH-MB SUFU PTCH1 SHH SMO PMC3980848__F3 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity STAT1 DROSHA NCOR2 SOCS1 BCL6 FOXP3 PMC7861947__F6 Probable mechanisms of apigenin against liver fibrosis MMP2 TGFA PMC4836414__F1 The butanone biosynthetic pathway PTS HEL-S-133P HPR PMC6694253__F3 Sub-network of SNHG12 BAD KIF23 HLA-G PLK1 NPNT TRIM7 TDG NRAS PTEN SPN MTOR HRH1 PI3 BCR MDM2 TWF2 RAVER2 EIF4B TEX19 RBL2 CD19 HEL70 STX7 MEI1 ARHA EIF4E SMARCE1 RHEB RXRA HEL-S-162eP TSC2 TSC1 WDR4 BCL2 SYK RAF1 MGA PMC8446364__F1 She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders IL1A CXCL10 GFAP CCL5 CCL2 MTOR IL1B MAFG PMC6826838__F7 Complement and coagulation cascades signaling pathway and RT-qPCR verification HEL-S-62p F10 TFPI CS CPB2 CD59 C9 PC F5 FH C7 VWF F11 ITGAX CR2 BOLL PMC9265562__F3 Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease PINK1 BCL2L13 FUNDC1 BNIP3 OPTN PMC7279331__F3 Calmodulin and protein kinase C (PKC) modulating critical features of KRas-driven tumourigenesis BCL2 RAC1 RAF1 PMC7279331__F2 Key signalling events modulated by Ca2+/calmodulin and decisive for cell proliferation and survival EGFR GRB2 HBEGF RAF1 PMC4916957__F2 IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance NRP1 PTEN PMC3888876__F2 MONOGENIC AUTOINFLAMMATORY DISEASES: DISORDERS OF AMPLIFIED DANGER SENSING AND CYTOKINE DYSREGULATION NLRP3 BCL10 TYK2 JAK1 TNF CARD14 PMC7056705__F2 Major mechanisms underlying induction of the host immune response by VPM1002 and M CGAS AIM2 IL1B PMC11726887__F10 Effect of echinacoside in HepG2 cells GPX4 FACL4 SLC7A11 SLC3A2 PMC9570382__F4 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer EGFR CDK4 CDK6 PMC3534598__F1 Cartoon depicting the role of sialidases during the multistep process of myogenesis NEU2 NEU1 NEU3 EGFR PMC6756057__F2 Schematic overview of genetic and epigenetic abnormalities in Wnt pathway components in MM and drugs that target canonical Wnt signaling ZNRF3 RNF43 APC SOST LRP5 MYC LRP6 DKK1 AURKA TBP CYLD CCND1 BCL9 PMC2748802__F18 Hypothesized descending pathway for translating emotional states or appetitive need for food, salt or water into goal-directed motor tasks SI NTS ARC PMC3323190__F7 Summary of the effects of leptin in the hypothalamus of control (A) and ob/ob mice (B), as revealed by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) and 13C High-Resolution-Magic Angle Spinning (HR-MAS) NPY AgRP ARC PMC8656934__F2 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy TSC1 APC MYC CD80 MTOR HEL-S-133P HK2 CD36 FOXP3 PMC8307196__F7 Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells EGF EGFR STAT5B PMC4376961__F3 Schematic overview of autophagy machinery and its regulation by sphingolipids ULK1 ATG3 ATG101 BNIP3 ATG14 PMC8656934__F3 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy ARG1 HEL-S-133P HK2 CD36 PMC4376961__F2 Key events in the apoptotic pathway and regulation of apoptosis by sphingolipids BAD BCL2 BMF FADD BAX PMC5518849__F1 An overview of one-carbon metabolism and the established/future therapeutics that target this pathway DHFR TYMS MTHFD1 PHGDH PMC9358979__F1 Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus NLRP3 PINK1 CGAS IL1B PMC3609811__F1 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress CD47 NPNT COL3A1 CD44 VWF CHAD ITGB6 ITGA4 SDC3 CD36 PMC3367552__F6 Interaction map showing potential links between the Par proteins and components of the Hippo pathway PALS1 RHO PMC5892236__F1 Resveratrol inhibits the mTOR signaling pathway in the repair of SCI TSC2 RICTOR MTOR IRS1 RHEB PMC3609811__F2 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress IL21R EPO FLT4 CCL21 TPO CCL2 OSMR BMPR2 KDR CCL14 CCL25 CSF2 CCL26 LTB TNF TSLP EDAR LEP IFNK CXCR4 IL2RG CCL20 CCL22 MPL XCL2 EGF CSF3 IL9 EGFR NGFR IL2 IL4 BMP2 LIF BMP7 IL24 TNLG7C PRL CNTF LTA IL3 IL23A CD40 IL6ST IL-21 FLT3 CCL23 IL20 OSM INHBE PMC8215697__F1 Developing Clostridia as Cell Factories for Short- and Medium-Chain Ester Production HBD ACR PMC5396623__F4 SPARC overexpression alters microRNA expression profiles involved in tumor progression IL36RN IL37 IL36A CTSC IL36B IL36G S100A12 MMP16 TNF STAT3 PMC8748963__F9 NLK/SRF/ELK Pathway NLK EGR1 RHO HEL114 PMC6627638__F10 Epigenetic regulation of survivin in transformed cells KDM2A KDM4A PMC8626591__F1 Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates HMGB1 P2RX7 CD40 CD80 PMC6716297__F7 SUCO related genes involved in the cell cycle pathway E2F4 SMAD4 STAG1 DBF4 ORC3 CDK7 CDC45 CDC20 CDC6 SMC3 CDK2 MDM2 RAD21 PCNA SKP2 MYT1 PMC11837758__F1 The metabolic pathway for the biosynthesis of monocyclic aromatic chemicals PTS XK XDH HEL107 DMD GALP PMC6678865__F4 Altered metabolism as the source of nadph biosynthesis ME1 HEL-S-26 GOT2 PSAT1 PSPH NNT PMC3282946__F4 miR-23b and tretinoin, which was associated with this miRNA in thyroid cancer, shared the common target genes, ALDH1A1 and ALDH1A2 TSC2 CD14 BRAF MAX EIF4E TNF HIF1A MTOR BDNF TRAF2 RHEB PMC6832683__F10 Schematic diagram illustrating the distinct roles of Nrp2 in corticostriatal pathway development, maintenance, and function SPN NRP2 PMC1885811__F4 Web-accessible pathway navigator TRADD TRAF6 RIGI AMTN TIRAP PMC10179549__F10 HMGB2 in the development of the diseases CGAS MMP2 FBP1 GC HMGB2 PMC7473503__F2 Androgen receptor pathway inhibitors and their mechanism of action CYP17A1 PMC6770608__F10 Diallyl trisulfide (DATS) protected the brain tissue against the damage induced by ischemia/reperfusion (IR) KEAP1 HEL-S-44 RBX1 PMC7412691__F6 Schematic diagram of the mechanism underlies miR‐155 function in chondrocyte apoptosis and catabolic activity MMP3 PIK3R1 IL1B PMC10926087__F1 Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma BOC CDON KIF7 GPR161 GSK3B SUFU EVC2 PTCH1 GLI3 DISP2 EVC SMO CSNK1A1 ADRBK1 PMC1852964__F2 APC-Beta-catenin-Tcf (Wingless-Wnt signaling) pathway ERBB2 APC PMC3965671__F6 Mechanisms by which Th17 and Th22 pathways contribute to psoriasis and atopic dermatitis CXCL1 CCL8 CCL11 CCL26 CXCL8 CXCL2 CCL5 IL25 IL16 AHR CCL24 GC CCL20 IL1B PMC8096904__F5 Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN PIK3R1 MLXIP MXD1 IGF1R EGFR SMAD2 TGFBR1 MYC TGFBR2 SMAD4 PTEN FGFR2 FGFR1 MXD4 MNT ACVR2A CCND1 FGFR3 HRAS MLX MXD3 MAX ERBB2 MYCL ACVR1B PIK3CA MXI1 MGA PMC4666791__F1 Schematic diagram shows major signaling pathways stimulated by IFNA/B (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs) IRF7 FOS IRF9 TRAF3 TRAF6 IRAK4 IRF3 IFNAR2 IL6 MYD88 IFNAR1 STAT1 TYK2 JUN STAT3 MAL PMC3965671__F5 The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs and Skin CXCL1 CCL11 CCL26 CXCL8 CXCL2 CCL7 CCL5 IL25 IL16 AHR CCL24 GC CCL20 PMC3965671__F4 Immunopathogenesis of inflammatory bowel disease (IBD) CXCL1 GC IL33 CCL20 CXCL8 CXCL2 IL1B NOD2 MLN PMC8579729__F1 Complement in ischaemia–reperfusion injury and transplantation HEL-S-62p CS MASP1 MASP2 PMC7923337__F8 Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer WDR3 YAP1 GATA4 PMC9619106__F7 Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato PRODH PRODH2 PMC8436174__F1 HER2-Directed Therapy in Advanced Gastric and Gastroesophageal Adenocarcinoma: Triumphs and Troubles EGFR MDM2 PTEN MTOR PMC8494520__F2 Immunology and Immune Checkpoint Inhibition in Ovarian Cancer – Current Aspects CGAS CXCL10 CCL5 PMC4508762__F3 Transcripts regulating the Wnt signaling pathway are putatively affected by up-regulated miRNAs expression in the PCOS patients when compared with control ROCK2 NLK DAAM1 LEP SIAH1 STOM APC CER1 SMAD4 SKP1 ARHA RBX1 PMC3185234__F1 Enterohepatic circulation of the bile ABCG8 ABCG5 CYP7A1 PMC6727741__F8 WDR92 in the axonemal dynein assembly pathway RUVBL2 PIH1D2 DNAAF2 RPAP3 HEL-S-94n RUVBL1 SPAG1 COIL PIH1D1 PMC5166530__F2 CTHRC1 in multi-signaling pathways SOX2 SMAD2 DPAGT1 MMP9 WNT1 LRP5 LRP6 ARHA CTHRC1 BMP4 WNT3A ROR2 SMAD1 PMC6986204__F2 Molecular mechanism(s) regulating human Beta-cell proliferation HEL57 IGF1R IGF1 GSK3B IRS1 DYRK1A PMC4163633__F1 Innate recognition of HCV RNA TBK1 ISG15 TRADD TRAF5 TRAF3 TRAF6 IRF3 PELI1 MAP3K7IP1 TRAF2 TLR3 MAVS PMC7589980__F1 Susceptibility genes present in the double-strand DNA break repair pathway for ovarian and breast cancer and its different correspondent risks levels in each disease PALB2 BRIP1 RAD51D BARD1 NBN MRE11A CHEK1 BRCA1 CHEK2 ATM BRCA2 RAD50 ATR RAD51C PMC4485443__F1 Structural determinants of SMAD function in TGFB signaling SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC8387325__F2 Recent findings within the C. elegans neuro-gut axis NPY SGK1 PMC2953617__F2 JS genes implicated in the Shh, Wnt, and PDGFA signaling pathway ARL13B PCM1 AHI-1 SHH CEP290 INPP5E PMC3632658__F1 Interplay between viruses and host mRNA degradation RNASEL MGP LSM5 DCP2 LSM7 DCPS LSM6 XRN1 LSM4 LSM2 LSM1 LSM3 PMC2886162__F5 SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD+ Metabolism and Signaling to the Control of Cellular Functions ENAM NAMPT NMNAT1 SIRT1 TF PMC2810404__F6 Hepatocyte expression of Serum Response Factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice EGFR HSD17B2 TOP2A IGFALS MCM5 CDC20 IGF1 MCM2 CCNB2 GHR CCNB1 GRB2 HSD3B2 RAD51 MCM10 PMC4257614__F4 Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases ADAM15 TGFBR1 GPR34 TNK2 MOBKL1A ECHDC2 RUSC2 EFHC2 B3GNT2 APP HDAC2 HAND2 CENPA PARVB RORC GAGE12H GAGE10 IL13RA2 CST11 RIBC2 IL13 MAGEE2 APPBP2 GNA13 FZD4 GTF2F1 FANCM PMC2693450__F3 Lipodystrophies: Disorders of adipose tissue biology CDA LPA TG PMC7185127__F2 Regulatory mechanism of mitochondrial quality control MFN1 MFF FUNDC1 FIS1 OPA1 PMC3356061__F2 Molecular pathway of activation of autophagy ULK1 AMBRA1 ATG101 UVRAG MTOR PMC7738881__F8 Schematic model depicting how 14-3-3σ performs anoikis resistance effects in HCC CASP3 EGF EGFR PMC3840213__F8 Graphic summary of factors regulating Beta-cell proliferation and size as a function of pancreas developmental stages IGF2 PRLR PRL PMC6163343__F1 HH-GLI signaling pathway HHIP BOC SUFU EVC2 PTCH1 GPR161 GLI3 EVC BCL2 SMO GAS1 ADRBK1 PMC8610101__F1 Complement Pathways HEL-S-62p C9 C4B_2 C4A PMC4420620__F2 Novel functions of viral anti-apoptotic factors IRF7 IRF3 TYK2 JAK1 IRF4 PMC4420620__F1 Novel functions of viral anti-apoptotic factors ATG3 UVRAG PMC5086033__F1 Microenvironmental Regulation of Hematopoietic Stem Cells and Its Implications in Leukemogenesis FOXC1 MSC LEPR PTPN13 CXCL12 CDH2 PMC8533566__F7 SOD3 Levels Is Detrimental to Retinal Homeostasis STX18 STX3A SLC17A6 PMC4087507__F1 NOD2/TLR4 signaling pathway TLR4 TRAF6 MYD88 NOD2 PMC7356051__F1 Mammalian Arg/N-degron pathway UBR5 ATE1 UBR1 UBR4 NTAQ1 NTAN1 PMC3141878__F1 TLR4 signaling cascade and evidence for modulation by neuropathic pain and opioids CD14 TLR4 IRAK4 MYD88 TIRAP TAB3 PMC2864389__F1 PI3K/AKT signaling pathway TSC2 PI3 BAD FOXO4 MDM2 PMC6265572__F6 MiRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults IGF1R APC GSK3B LATS1 LATS2 PMC4069271__F1A Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1B): Is It a Rare Exception? AHR VHL PMC9168372__F2 Anti-Inflammatory Activities of Betulinic Acid: A Review VCAM1 TNF PMC6322862__F1 Schematic diagram of a simplified model for glucose-mediated mitochondrial transport regulation MAX OGA OGT GAA PMC7897195__F4 SFRP2 overexpression in tumor endothelium leads to enhanced tumor angiogenesis via the Wnt/Ca2+signaling pathway TEC NFATC3 FZD5 PMC7897195__F2 SFRP2 and the canonical Wnt signaling pathway APC LRP5 LRP6 PMC4861365__F1 The Fanconi anemia/BRCA repair pathway FANCD2 BRCA2 ATRIP RAD51 ATR BRCA1 USP1 PMC7057837__F1 Role of RUNX Family Transcription Factors in DNA Damage Response CDKN1A FANCD2 ATM MDM2 GADD45A ATR BAX PMC9251345__F5 Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19 PINK1 AIP APAF1 ALG12 ALG10 ALG14 DIABLO DKFZp686F0183 HTRA2 FIS1 OPA1 BAX PMC8039963__F7 Genetic and molecular signal dynamics that ZEN mainly affected during PF assembly WNT4 YAP1 FZD2 AXIN1 SMAD4 WAS ID1 TEAD2 PMC2556568__F2 Molecular processes that handle — and mishandle — dietary lipids APOB PC DGAT2 ABCG8 ABCG5 APOBEC1 NPC1L1 ABCA1 DKFZp434B2017 TG ACAT2 PMC7057837__F3 Role of RUNX Family Transcription Factors in DNA Damage Response RUNX3 RUNX1 FANCD2 BLM PARP1 ATR PMC5847265__F1 Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children SQLE APOA4 LIPC SCARB1 ABCG8 ABCG5 APOC2 APOC1 APOC3 HMGCR CYP7A1 APOB PLTP FDFT1 LPL LDLR SOAT1 ABCA1 APOE PMC4436943__F1 Wnt/Beta-catenin signalling pathway APC LRP5 LRP6 PMC5078078__F6 NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling TBK1 IKBKE IKBKG CSF3 IRAK1 EGFR MAPK3 RELB TRAF3 TRAF6 EIF2AK2 MTOR IFNG NOD1 TNFSF14 CSF2 JUN RELN EGR1 MAP3K1 FOS SLC20A1 TNF IKBKB CARD11 TNFRSF1B LTA CD27 NFKB2 TNFSF10 ZAP70 CARD10 RAF1 TNFRSF10B CSF1 FADD LTBR PMC10526378__F3 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors SOCS3 STAT3 PMC10526378__F1 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors EGFR MTOR STAT3 PMC9099213__F1 “Self-Sacrifice” of ImmuneCells in Sepsis NLRC4 NLRC3 GSDMD PMC2888584__F7 Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1A in Melanoma Cells HEL-S-28 VEGFA MTOR PMC7802795__F13 Possible mechanism of anticancer activity of SnO2-ZnO/rGO NCs CASP3 NPS PMC11275100__F1 PARPi effect in cancer cells and immune cells CGAS BRCA2 BRCA1 PMC3496044__F7 Sialic acid biosynthetic and degradative pathways GNE CMAS NANP PMC5823602__F4 UBASH3B promotes tamoxifen resistance and could be negatively regulated by ESR1 UBASH3B PMC5023837__F2 Ingenuity Pathways Analysis of the identified methylated targets MMP3 MIA3 HSPB7 NEF3 TEKT4 NKX6-2 AKAP9 PRKAB2 CP PMC1487177__F7 AKT-1/PKB Signaling PTEN INSR PMC5329888__F3 Sex determination within individual XY supporting cells depends on the level of Sox9 expression.A RSPO1 SOX9 FGF9 SRY PMC10529750__F6 Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis MRGPRD SIRT3 PMC7854989__F2 Novel insights provided by single cell transcriptomics regarding hepatocytes and hepatic NPCs in nomal liver and during various injuries and pathological conditions CD9 CCR2 PDGFRA BMP2 VEGFA S100A9 HEL-S-104 LPAR1 S100A6 NGFR NRP1 opn S100A8 CXCL9 TNFSF12 IL1B CD36 PMC8250138__F2 Tetraspanins: Novel Molecular Regulators of Gastric Cancer TSPAN5 CD82 EGFR TSPAN9 CDK4 CD81 PMC8250138__F1 Tetraspanins: Novel Molecular Regulators of Gastric Cancer EGF CD151 EGFR TSPAN8 TSPAN4 PMC6482252__F2 The physiological generation and function of lipid mediators in immunity LTA COX1 TES ACOX1 PMC6482252__F1 Mechanism of foam cell formation ACAT1 ABCG1 LDLR ABCA1 IL1B CD36 PMC4865504__F1 Human and rodent adrenal steroidogenic pathways LDLR HSD3B2 STAR CYP11B2 PMC2856637__F1 Simplified scheme of early FcERI-mediated signaling events BTK FYN BCL10 GAB2 LYN GRB2 SYK SNAP23 STIM1 PMC3508169__F2 Known relationships between the candidate genes IRS4 HEL-S-28 SLC8A1 BST2 INSR PRKCA CD109 TLR4 PRKCB ITGA6 SRC PTPRE ADAM10 ITGAV FASN PMC11008418__F8 Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis GPX4 SLC7A11 SLC3A2 SIRT1 GSDMD PMC9016198__F1 Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early Anticoagulation ACE2 TF TMPRSS2 PMC7962940__F7 Role of miR-548m in regulating EMT in breast cancer AHR MMP9 SNAI2 PMC7376987__F2 Summary of recent advancement toward heart regeneration PITX2 CXCR4 CXCL12 PMC10535706__F8 Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/Beta-catenin signaling pathway to counter the progression of colorectal cancer TPH1 GIG8 AHR PMC7312731__F1 Differential activation of downstream molecules of the insulin-like growth factor (IGF) signaling network BAD SOCS3 IGF1 FOS GRB2 IRS1 PXN STAT3 PMC3924581__F1 AEG-1/MTDH/LYRIC promotes hepatocarcinogenesis MMP9 IGFBP7 SND1 PMC3028977__F6 CD36 contributes to inflammation and impaired insulin signalling in adipocytes and macrophages FYN LYN CD36 PMC6434857__F2 Possible therapeutic implications of resveratrol/metformin/exercise in cognition through osteocalcin signalling GPR158 BDNF SIRT1 PMC3414724__F2 Role of the PI3K pathway in B cell antigen presentation functions BTK PI3 BCR PMC3414724__F1 Major components of the PI3K pathway in B cells discussed in this review PI3 BCR LYN SYK PTEN CD19 PMC3414724__F4 Alterations in the PI3K pathway in malignant B cells PI3 BCR SYK PTEN CD19 PMC9120413__F7 Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome NLRP3 ANXA1 MYD88 IL1B PMC7000863__F1 Unfolded protein response (UPR) pathway ATF4 EIF2A MTOR PMC7973386__F1 Representation of NAD+biosynthesis pathways NAPRT NAMPT SIRT7 SIRT4 SIRT5 SIRT6 NMNAT3 SIRT1 SIRT3 PMC4454471__F3 Model for generation of repeat expansions during MMR and BER FEN1 MSH3 MSH2 WRN PCNA PMC5062167__F8 Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model PTMS PMC7016612__F3 Crosstalk between primordial follicle activation and DDR pathway TSC2 KL KIT TSC1 ATM FOXO3A BRCA2 RAD51 PTEN RPS6 BRCA1 PMC7278809__F1 NAD+ biosynthesis pathways NAPRT NAMPT PNP PMC7016612__F5 Molecular relationship between phosphoinositide 3-kinase/protein kinase (PTEN/Akt) activation, DNA damage and decreased ovarian reserve AMH ATM PTEN H2AX BAX PMC8982613__F6 Infantile hepatic hemangiomas: looking backwards and forwards PTEN MTOR HEL-S-133P HK2 PMC4576203__F2 Participation of HPV oncogenes at different levels of Wnt/Beta-catenin cell signaling regulation SIAH1 NKX2-1 FOXM1 APC GSK3B MZF1 PMC4576203__F1 Wnt/Beta-catenin cell signaling pathway FOXM1 APC PMC8833126__F9 Novel pyroptosis-related signature predicts prognosis and response to treatment in breast carcinoma NLRP3 FGF21 GBP1 IL18 FOXO3A GJA1 IL36B IL36G IRF3 GSDMC DFNA5 PMC5056258__F1 PI3K/AKT/mTOR pathway is a critical pro-survival cell signaling pathway within NETs that mediates cell growth and peptide translation TSC2 TSC1 PTEN MTOR PMC10308444__F5 Integrated transcriptome and microRNA sequencing analyses reveal gene responses in poplar leaves infected by the novel pathogen bean common mosaic virus (BCMV) KIT PDC PC PMC10884126__F8 Interaction networks of “pathways-differentially expressed lncRNAs-target genes” CD14 FOSL1 COL3A1 PGLYRP4 SPINK6 COL1A1 COL6A5 EGFL6 SIX4 PPP1R1B PMC5071376__F2 Diagrammatic representation of the integration of leptin and insulin signals in the regulation of energy homeostasis in the central nervous system POMC NPY STAT3 PMC5896366__F2 EGF receptor (EGFR) effects on ABC transporters EGF EGFR PTEN ABCG2 ABCB1 PMC6948191__F3 Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies TLR8 INA CGAS TLR7 TLR9 IRF7 IRF3 CDK4 MYD88 AIM2 TLR3 MAVS PMC5477576__F4 Intrinsic apoptosis pathway BAD EIF2A TRAF2 BAX PMC5477576__F3 Extrinsic apoptosis pathway TRADD FADD TAB3 PMC7379086__F2 Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy OGA RUNX2 OGT PMC3104927__F6 RHIM-dependent signaling TBK1 TLR4 RELA IRF3 TLR3 PMC9411667__F3 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis STAT1 NLRP3 KEAP1 TRAF6 JAK3 MYD88 JAK1 MTOR HMOX1 BACH1 STAT3 PMC9411667__F2 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis NOTCH4 SMAD6 SMAD4 TRAF6 MYD88 MTOR STAT1 NLRP3 NOTCH1 JAK3 JAK1 STAT3 MAL PMC9574357__F2 IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers TLR7 TLR9 HEL-S-11 LIF CA3 MYD88 GAL PMC3922145__F3 Differential expression of mTOR and HIF-1A pathways between leiomyoma, HLRCC and leiomyosarcoma TSC2 EGR1 TSC1 MTOR RHEB PMC8196684__F1 Methylation Patterns of DKK1, DKK3 and GSK3B Are Accompanied with Different Expression Levels in Human Astrocytoma APC GSK3B LRP5 LRP6 PMC10929826__F8 MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis MUC1 TBK1 HIF1A MTOR IFNG PMC8085163__F1 Isoprenoid biosynthetic pathway RAP1A FDPS IPP PMC8237035__F1 SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19 TH PDC CLU PMC3091670__F3 Complement pathway CD59 C4B_2 MASP1 C7 C6 MASP2 CR2 C1S CR1 PMC3091670__F2 Interferon signalling cascade IFIT3 STAT2 IRF9 IFITM1 MX2 MX1 STAT1 OAS2 TAP2 TYK2 NOS2 IRF-1 PSMB8 IFIT1 PMC4838842__F7 Resveratrol enhances HBV replication through activating Sirt1-PGC-1Alpha-PPARA pathway NR1C1 SIRT1 CP PMC10523328__F2 Tactile twist: decoding the phenomena of mechanical itch and alloknesis PIEZO2 NPY UCN3 PIEZO1 GRPR NPPB FOXP2 CALCR ITCH PMC4062953__F2 Classical and non-classical pathways of androgen biosynthesis AKR1C1 CYP11A1 CYP7B1 UGT2B17 HSD17B2 RDH5 AKR1C2 HSD17B10 UGT2B15 HSD17B6 STS DIO1 HSD17B3 SULT2B1 UGT2B7 CYP17A1 PMC7835009__F6 VEGFR1-specific signaling pathway that HIF1A participates in PLCG1 MAPK3 VEGFA HIF1A NRP2 PDPK1 CBL CALM1 NCK1 SHC2 PTPN11 VEGFB CD2AP PMC4062953__F1 Steroid hormone synthesis pathways in the adrenal gland and testis HSD11B2 STS HSD11B1 CYP11A1 HSD3B2 HSD17B3 CYP17A1 STAR CYP11B2 PMC7774019__F8 EBV early protein BFRF1 inhibiting RLR-mediated IFNB signaling pathway TBK1 TRAF3 IRF3 PMC9599947__F2 STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer EGFR ZNF596 STAT3 PMC6722688__F1 A simplified diagram of the metabolic fate of maternal dietary choline and its delivery to the developing fetus PC PEX3 PEMT PMC9243343__F2 Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy ROCK1 MTOR PMC4114106__F2 Ubiquitination of RIP1 is an early pro-survival checkpoint in TNF signaling CASP3 TRADD FADD TAB3 PMC8505648__F4 Targeted therapy of BCBM treatment VEGFA CDK4 MTOR CDK6 PMC4034039__F5 Proposed lignin degradation pathway in C H1-6 TH PMC6278600__F1 Postulated cellular mechanisms of 20-HETE bioactions in the blood vessel wall GPR75 EGFR ARHA IL6 EIF4E PMC5392205__F10 Atorvastatin inhibits the immediate-early response gene EGR1 and improves the functional pro of CD4+T-lymphocytes in acute coronary syndromes IL10 CCR2 EGR1 TLR4 FOS MYD88 PMC12175327__F1 Neutrophils interact with CTCs through both direct and indirect mechanisms SIRPA CXCL1 CD47 VCAM1 PMC11032202__F6 Intratumoural heterogeneity informs intertumoural heterogeneity NLGN3 VHL HIF1A PMC11032202__F3 Oncogenes versus tumour suppressor genes in glioblastoma NF1 EGFR MYC PIK3CA PTEN RB1 CDKN2A PMC12175327__F4 Nanomaterials for driving neutrophil repolarization toward the N1 phenotype, degrading ENTs and modulating neutrophil infiltration CGAS NPS MMP9 LTB IRF3 COIL PMC3499024__F2 Bone anabolism regulated by statins RUNX2 BMP2 RHO PMC5140697__F1 Targeting cancer metabolism: dietary and pharmacological interventions MYC PSPH ACLY HIF1A MTOR HEL-S-133P PHGDH FASN GLS PMC4965903__F1 IL-7RA pathway mutations provide potential targets for acute lymphoblastic leukemia therapy PTEN MTOR TSLP PMC5140697__F2 Targeting cancer metabolism: dietary and pharmacological interventions IGF1R IGF1 EGFR MTOR PMC4673467__F2 Wnt signaling pathways APC RHO PMC9382782__F2 Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation IL33 CCL2 PMC7612338__F1 ISR signaling pathway ELF2 DELE1 ATF4 IMPACT EIF2A OMA1 PMC8505648__F3 Interactions between cancer cells and resident cells STAT1 EGFR MYC BCL2 PTEN GSTA5 PMC8613896__F2 New perspectives on the treatment of hidradenitis suppurativa NLRP3 CXCL1 CCL20 CXCL8 CXCL6 CCL2 TNF CXCL11 PMC6886244__F1 Scheme of the N-linked glycosylation pathway ALG11 GNE PGM3 GMDS ALG13 ALG5 FPGT DOLK CMAS ALG2 NANS ALG12 MNS1 NGLY1 CAD GMPPB NANP PMC7016612__F2 DNA double-strand breaks (DSBs) response pathway DMC1 ATM CDK2 BRCA2 MDC1 BCL2 RAD51 CDK4 CDC2 PMC3370283__F2 Somatic Activating PIK3CA Mutations in CLOVES Syndrome(A) Demonstration of the PIK3CA c.1624G>A somatic mosaic mutation in participant CL4 PIK3CA PTEN MTOR PMC10990851__F9 Integrated transcriptomic and metabolomic analysis reveals the regulation mechanism of early bolting and flowering in two cultivars of Angelica sinensis PRR9 ELF3 PRR7 RFWD2 PMC10990851__F8 Metabolic pathway map of biosynthesis related to photosynthesis BAD PC FES PMC10148099__F7 Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease CS BCAT2 ACSS3 ACSS2 ACOT12 HEL-S-32 MDH2 AOX1 ACADS FH ACO2 OGDH SUCLG2 DLAT SDHA SDHB FASN MCEE HMGCL DLD PCCA DBT PDK4 IDH3B PCCB ABAT BCAT1 ACSF3 SUCLG1 EHHADH PMC3006139__F6 Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse TLR7 TANK TLR4 IRF7 IRAK1 IRAK4 MYD88 TLR3 NFKBIE TIRAP PMC8046925__F6 Visual pigment cycle reactions in vertebrate and invertebrate photoreceptors: (A) Pathways for visual pigment regeneration in the vertebrate retina, including both the classical and non-classical pathways LRAT RGR RPE PMC8511580__F1 Biological signaling networks related to PM10 & PM2.5 exposure inducing skin-related cellular processes and diseases CHUK MPO CSF3 CXCL5 EGFR PROC CREB1 CCL2 SOX9 BMP4 FGFBP1 FST JUP SCD PDGFA BMP5 THBS1 CSF2 NR1H3 JUN KRT14 AKAP12 EGR1 BMP2 FGF2 LIF CXCL10 VEGFA CXCL2 CCL4 HMGA2 TNC EDN1 HNF4A TIMP1 RELA CCL20 KLF4 HEL113 GNAS TRAF2 PPARG INHBA PMC4905302__F1 Autophagy regulatory pathway ATG12 ATG3 ATG10 ATG14 DKFZp686F0183 PMC3721080__F6 Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks RS1 PRKCE POR TNF MTOR PRCD PMC4811737__F1 Cellular and molecular mechanisms implicated in regulating the balance between tolerance and rejection in the mouse liver transplant model CD80 IFNG PMC5460589__F2 The folate biosynthesis pathway and its compartmentalisation in plants (modified from ) DHFR FPGS DHPS PMC2710681__F4 Model describing TLS across CPD in human cells POLK POLG POLM PMC2773638__F4 Coordination of extracellular and intracellular signaling regulates cytoskeletal dynamics and axon formation APC GSK3B ARHA RAC1 BDNF CDC42 PMC5112569__F6 Regulation of Sirt1/Nrf2/TNFA signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity TRADD KEAP1 MTOR KIF9 SIRT1 PMC4736967__F1 Wnt/Beta-catenin signaling in ASDs TSC2 TSC1 APC LRP5 LRP6 PMC5540363__F1 Oxygen regulation of ESC metabolism and epigenetic landscape GNE SOX2 GC PMC2684849__F3 Transcriptional regulation of human small nuclear RNA genes BRF2 TBP BDP1 TXN PMC11703929__F1 Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis TBK1 CGAS IRF3 PMC5082570__F1 Mammalian choline degradation pathway with DMGDH as metabolic branch point HEL-S-182mP BAD PIPOX PMC8450567__F5 Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy CYB SDHD PMC4941269__F4 Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer BAD SNAI1 ARHA ID1 CRK PMC8546664__F2 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy CGAS ATM IRF3 ATR IFNG PMC8546664__F1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy POLD4 POLD2 CETN2 RPA3 TDG NBN POLL UNG PARP4 MLH3 POLE2 POLE4 POLE POLR2B MBD4 POLE3 MSH6 RPA4 RAD50 MSH3 MSH2 GTF2H4 XPC BARD1 DDB2 MRE11A BRCA1 CUL4A GTF2H2 GTF2H3 SSBP3 BRCA2 XPA ERCC2 ATR PCNA BLM CCNH WRN CDK7 APEX2 ATM PRKDC NEIL2 DNTT NEIL3 RPA1 SLX4 MPG PARP3 POLD3 GTF2H5 RFC3 RFC4 PMS2 RFC2 GTF2H2C_2 RAD9B PARP2 MUTYH PNKP POLM PMC7789510__F6 Simplified schema and functions of SAUR genes in plant evolution TH MAX ARF6 PMC9604794__F15 Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes MOS DAP TUB PMC3214273__F1 Pathogenic microbes and community service through manipulation of innate immunity TLR4 CXCR4 GSK3B CA3 TLR1 PMC7606465__F7 Next-generation sequencing analysis of circulating micro-RNA expression in response to parabolic flight as a spaceflight analogue ATM CDK2 MDM2 CDK4 PMC6050486__F5 Schematic drawing of epigenetic reprogramming in Dnmts, Sfrp4 and Wnt/B‐catenin pathway from the foetus to offspring SFRP4 FOSL1 APC GSK3B LRP5 HIF1A PMC7541692__F1 Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway in melanoma NF1 BRAF NRAS PMC7586430__F2 Regulation and functions of NEDD4 E3 ligases in cardiac disease CCNA2 YBX1 SMURF2 CCNB1 TXNIP EZH2 WWP1 SMAD1 TGFB1 DKFZp781O1323 ITCH PMC9162043__F7 Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis-dependent AKT/mTOR signaling IGF1R MTOR POU2F2 HEL-S-133P HK2 PMC7586430__F1 Ubiquitination-proteasome of NEDD4 E3 ligases pathway WWP1 NEDD4 ITCH PMC3919808__F9 Pathophysiology of Acute Kidney Injury DIABLO HTRA2 FADD PMC7586430__F3 Regulation and functions of NEDD4 E3 ligases in vascular disease SEPTIN4 RUNX2 BMP2 SMURF2 TGFBR3 SMURF1 TGFB1 PMC6159944__F9 Schematic pathway representing findings of this study CYP27A1 CES1 ABCG1 ABCA1 CD36 PMC6834859__F1 Effect of GPCRs on RTK transactivation EGFR SRC MTOR PMC5866970__F2 Regulation of the Hippo pathway in endothelial cells ANKRD1 VCAM1 RHO PMC5653513__F2 PD1-dependent inhibitory mechanisms CDK2 ZAP70 PTEN ITCH PMC5866970__F1 Components of the Hippo/YAP pathway LATS1 LATS2 PMC7937835__F3 Lessons from mitochondrial proteostasis in adipose tissue GDF15 ATF4 ATF5 PMC9138536__F2 Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence IL10 CTSS PRKCQ CXCL10 CXCL3 CXCL2 TNF TNFRSF13C CCR1 TLR4 SEMA4D WIPF3 CFH BASH MILR1 CDK2 ANXA2 GC ZAP70 GRB2 SHC4 DOCK2 OSM COL4A1 PMC5866970__F3 Regulation of the Hippo pathway in smooth muscle cells CYR61 MYC CCND1 RHO PMC2586935__F4 TGFB pathway as affected by IGF2 administration based on Pathway-Express E2F4 NODAL ROCK1 PITX2 SMAD2 TGFBR1 SMAD6 SMAD4 SKP1 ARHA TNF RBX1 SMURF1 IFNG FST SMURF2 THBS1 SMAD1 DKFZp781O1323 PMC5889571__F2 CD109 and TGFB signaling CD109 SMAD2 TGFBR2 SMAD4 TF PMC3562293__F2 Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities PC LPL RHO RAC1 LPA MTOR PMC8213678__F8 Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer TH RAD1 PRLR GCK PMC7487321__F3 Oxygen-dependent pathway of plasmalogens biosynthesis in animals FAR1 PC PMC2453072__F3 The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant DCD DUT UNG PMC10573127__F3 Secretory cell (SC) differentiation programs AQP5 FOXM1 RUNX2 IL13 SFTPD KLF5 SPDEF HEL-S-116 PTGER3 SCGB1A1 MUC15 MCIDAS CFTR SFTPB FOXA2 SCNN1B MUC5AC MYCL CLCA1 GMNC SFTPA1 KLF4 FOXA3 SCNN1G PMC10573127__F2 Molecular pathways involved in multiciliogenesis MYB MCC E2F4 RFX3 RFX2 NOTCH1 MCIDAS FOXJ1 CCNO PMC10573127__F1 Airway epithelial differentiation pathways MYB KRT16 NGF RFX3 TP63 SPDEF KRT23 SCGB1A1 MUC5B CFTR CCNO KRT6C FOXN4 SCGB3A2 MUC5AC RFX2 TP73 DEUP1 KRT13 KRT5 CDC20B KRT4 KRT14 PMC2676730__F5 The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association Studies DIO1 PMC5006437__F1 Regulation of molecules in the NMDAR signaling pathway on learning and memory MAP2 ARC BDNF PMC5799812__F6 A convergent model for the pathogenesis of ANKL IL10 MYC TET2 PMC6996369__F6 Scheme of predicted AJP001 signaling and the antibody production induced by the AJP001 conjugate peptide vaccine TH NLRP3 TLR4 IL1B PMC2959043__F3 Wnt/Beta-catenin signaling Ctenophore pathway APC LRP5 LRP6 PMC2688747__F4 Fgf and Sdf-1 Pathways Interact during Zebrafish Fin Regeneration FGFR1 WNT10A WNT5B PMC9477422__F7 Ptprh mutant mouse tumors failing to dephosphorylate EGFR CDK2 PTPRH EGFR PMC7707548__F6 Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells GC DHODH H2AX PMC2724309__F2 Steroidogenesis pathway: Steroids are in bold; enzymes and cholesterol transport proteins are in italics CYP11A1 PBR STAR PMC8236385__F1 Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses TLR7 IRAK1 LBP TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TAB3 MAL PMC4063840__F2 In vivo gut transcriptome responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in neonatal gnotobiotic piglets HMGB1 TNF PMC6892982__F1 Autophagy regulators and functions associated with anti-aging effects TSC2 TSC1 TFEB PARK2 NUFIP1 FUNDC1 BNIP3 NBR1 PMC4002088__F7 Schematic representation of the proposed novel TXNIP/miR-124a/FOXA2/IAPP signaling pathway TXNIP IAPP FOXA2 PMC9287895__F3 Emerging strategies to overcome resistance to third-generation EGFR inhibitors RET ALK NTRK1 EGFR MYC GRB2 SRC PTEN MTOR AXL ROS1 STAT3 PMC3936199__F3 Iron homeostasis in the liver EPOR EPO TMPRSS6 HFE CEBPA TFR2 STAT3 PMC5344902__F2 Type I interferon (IFN) signaling STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC5344902__F1 Pattern recognition receptor signaling that leads to the induction of type I interferons (IFNs) TBK1 CGAS TLR9 TRADD IRF7 IRAK1 TRAF6 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 CSA2 MAVS PMC5316308__F2 DREAM as a novel therapeutic target for anti-thrombotic agents BTK FYN LYN TEC SRC SYK PLCG2 LAT PMC12250001__F3 Principal microRNAs and targets involved in inflammation and cartilage destruction in OA MMP3 ADAMTS5 BCL2L12 VCAM1 HBEGF SP1 SIRT1 PMC6551314__F8 Proposed model for the role of Them2 in hepatic VLDL secretion DGAT1 GPAT4 DGAT2 LPA TG PMC2691965__F2 Toll-like receptor (TLR) activation CD14 TLR5 TLR7 TLR4 TRAF6 IRF3 MYD88 TLR1 TLR3 TIRAP PMC7880350__F8 Schematic illustration the contribution of FGF23 induced by post-infarct heart failure to promoting renal fibrosis FGF23 GSK3B FGFR4 WAS PMC5497057__F2 Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer PDGFRA BAK1 EGFR APC PTEN RB1 MTOR CDK6 INSR TSC2 NF1 TSC1 ATM MDM2 STK11 CDK4 PMC12250001__F2 Principal molecular mechanisms involved in the MAPK, NFKB, and PI3K/Akt signaling pathways activated by oxidative stress in OA ADAMTS5 KLF10 PTEN PMC11942346__F1 Mechanisms of adhesion formation: (1) Inhibition of fibrinolysis and ECM deposition PLG PMC9465188__F1 Recent advances in the therapeutic efficacy of hepatocyte growth factor gene‐modified mesenchymal stem cells in multiple disease settings HGF VCAM1 CXCR4 S1PR1 BAX FOXP3 PMC6767550__F2 Canonical and noncanonical signaling pathways of NOD1 and NOD2 TBK1 ATG16L1 NOD1 IRF3 RIPK2 MAP3K7IP1 NOD2 MAVS PMC8606592__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer TUG1 PMC6986015__F9 Schematic depiction of main conclusions CASP3 ATF4 CASP8 PMC3648641__F1 Unraveling Mechanisms Regulating Systemic Iron Homeostasis BMP6 SMAD4 TMPRSS6 HFE TFR2 PMC4661576__F1 The fate of chemoresistance in triple negative breast cancer (TNBC) ABCG2 MSH2 BAX PMC6981617__F2 General metabolism and elemental sulfur-mediated cellular responses in Palaeococcus pacificus DY20341T HEL-S-11 PGP FES SHE APRT POR PMC6180304__F2 Three key innate immune pathways for the most common retinal degenerative diseases STAT1 HEL-S-62p SOCS3 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 SIGLEC11 PBR SOCS1 PMC6743306__F6 Proposed model illustrating the roles of CHL1 during NPC carcinogenesis CHL1 ARHA RAC1 CDC42 PMC1899901__F6 A schematic model depicting the role of Artemis in the cellular response to IR PLK1 WEE1 ATM CDC2 PMC5003840__F1 Proposed biosynthetic pathway to the synthesis of xanthanolides PTS COCH GAA PMC9239773__F6 Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics SMAD4 CXCL12 PMC151822__F2 Signaling UPR-mediated cell death ATF4 TRAF2 PMC10177044__F2 Ratio of p38 signaling to ERK determines whether cancer cells enter a dormant state or undergo proliferation LOXL2 HGF CX3CL1 IGF2 MMP9 IL8RB DKK1 GDF10 BMP4 CXCL16 GREM1 IGF1 MMP2 CXCR4 TGFBR3 PMC6736652__F1 Predictive biomarkers for bevacizumab efficacy in breast cancer MVD MMP2 AGTR1 MMP9 VEGFA PMC8465904__F4 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells APC GSK3B MDM2 FADD BAX PMC8465904__F3 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells APOF BAX PMC9684870__F3 Disease-specific tissue glycosylation APC POMT1 CCL2 PMC8465904__F2 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells EGF HGF CSF3 MMP9 EGFR APC PDK2 GSK3B CD44 LATS1 TNF LATS2 MMP7 MMP2 CSF2 CSF1 PCNA POLI BOK PMC9237610__F1 Genetic Manipulation of Biosynthetic Pathways in Mint PGR HMGCR PMC5407862__F1 Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective HGF BRAF EGFR MAPK1 PTEN MTOR PMC8465904__F1 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells APC ALB GSK3B RYK RHO CDC42 PMC2423297__F9 The role of cAMP-stimulated adipogenesis via PKA- end Epac1-dependent processes IGF1 GRB2 RHO PMC9217905__F1 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review MMP7 COX2 APC CCND1 PMC6367888__F6 Gene-pathway network of 26 DEGs ISG15 IFIT3 OASL GBP1 IFIT2 RSAD2 CXCL10 IL6 MX1 PMC3387493__F1 Dual Aspects of Altered Bone Remodeling in Psoriatic Arthritis BTK SEMA4D RUNX2 TNF PMC2910898__F1 During normoxia, HIF-1A is rapidly degraded by the ubiquitin-proteasome pathway EPO HIF1A HEL-S-133P PMC10380201__F7 Small-Extracellular-Vesicle-Derived miRNA Profile Identifies miR-483-3p and miR-326 as Regulators in the Pathogenesis of Antiphospholipid Syndrome (APS) VCAM1 F3 CD80 PTEN MTOR TF PMC6522926__F5 Schematic representation of the E2/ESR1/CD36/PPARA pathway in skeletal muscle cells TG FASN CD36 PMC9217905__F6 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review MMP7 COX2 APC CCND1 PMC5902023__F1 Mammalian isoprenoid biosynthetic pathway with associated inhibitors FDPS RHO IPP PMC3091595__F2 Bcl-2 as an attractive target for modulating different modes of cell death in cancer therapy due to close communications with mediators of apoptosis, programmed necrosis, and autophagy TRADD FADD BAX PMC3947362__F7 The proposed model for the signaling events in mature, human oligodendrocytes in response to B. burgdorferi CXCL8 CCL5 CCL2 PMC8753521__F5 Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer HMGB1 ADIPOR1 ADIPOR2 GCLM GCLC VEGFA PTEN RHO RB1 MTOR RYR2 NLK OGT CXCR4 MPC1 SIRT1 STAT3 PMC9217541__F7 Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking COL3A1 PGR PPARG IRF-1 MVP SELE PMC8045279__F1 Leptin signaling pathways POMC SOCS3 PC NPY AgRP GRB2 STAT3 PMC9368893__F3 Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia IGF1 IGF2 MTOR BAX PMC7869230__F9 IL-17 signaling pathway cascades obtained from the global proteome data by KEGG pathway analysis TRADD IL17D MMP9 CD44 TRAF6 CCL7 CCL2 USP25 TNF IL17RB IL17RC MMP3 COX2 TRAF2 FADD TRAF4 ELL BOLL PMC9631787__F1 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 MPO SMAD2 MYD88 ACE2 TGFBI PMC2172900__F9 A model of how the Tor1/2 and Lst8 proteins affect amino acid biosynthesis and Gap1p sorting HEL-S-26 MKS1 PMC9631787__F3 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 EGF SMAD2 TRAF6 CDH2 MTOR ACE2 TGFB1 PMC4524397__F5 Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity TIGIT FGL2 FOXP3 PMC3119514__F3 IL-1 and TLR activation pathways TBK1 TANK IRAK1 TRAF6 IL1R1 MYD88 MAP3K7IP1 TIRAP PMC7710592__F1 Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in Caenorhabditis elegans ADA APRT ADK PMC3119514__F2 TNFA and TCR activation pathways PLCG1 TRADD TRAF6 MAP3K7IP1 CARD14 CARD9 BCL10 TRAF5 LCK ZAP70 CARD10 TRAF2 FADD PMC6650964__F5A Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment HEL-S-94n AP2A2 ATP2B2 PPP2CA HEL-75 HNRNPA2B1 DEK STX1A ARL8B HEL-S-271 PMC3177043__F2 Different pathways of myostatin signalling IGF1 GSK3B CCND1 MTOR PMC3119514__F6 RNA polymerase II transcription complex TRAF1 SP1 PMC5266810__F1 Interorgan crosstalk involved in Beta-cell failure IL16 IL1B IAPP PMC8014382__F1 Tumor cell and T cells: the pathways that involve MDSC cells, CD8+ T cells, Tumor cells, NK cells and chemotherapy drugs were constructed KIT RET APC VEGFA PMC5054393__F7 Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells DUSP4 STAT2 MAPK8 ZFYVE9 TGFBR1 MAPK3 IFNGR2 MTOR ST13 STAT1 PIM1 DUSP5 DUSP10 EP300 DUSP16 MAPK1 DUSP8 PMC7212460__F2 Canonical Wnt/Beta-catenin pathway APC GSK3B PMC4636403__F5 Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells F10 TFPI PLG F8 F9 DHCR24 MX1 A2M F2 F5 F3 GSTM4 VWF KNG1 SERPINF2 CP PMC3129504__F2 Ras/Raf/mitogen-activated protein kinase pathway EGF BRAF EGFR GRB2 PMC8014382__F2 APC cells and T cells: the pathways that involve OX40/OX40L, PD-1/PD-L1, mTOR/Akt, NKKB/NFAT and Cyclin A/CDK were analyzed BATF3 SIRT7 APC IL4 MTOR SIRT1 FOXP3 BATF PMC6395653__F3 The metabolic network PALM CIT MAL PMC7912842__F1 Fibroblast growth factor-FGF receptor (FGF-FGFR) and cyclin D-cyclin-dependent kinase (CDK)4/6 pathways in breast cancer TSC2 CDK2 FRS2 GRB2 C6 CCND1 CDK4 MTOR CDK6 PTX3 PMC3548172__F3 Cooperation of esBAF and PRC2 during pluripotency maintenance SOX2 LIF STAT3 PMC7407918__F3 Signaling pathways involved in exacerbating oxidative damage and liver injury CD14 EGR1 TLR4 TRADD IRAK1 TRAF6 NOX4 RAC1 MYD88 TRAF2 IL1B PMC8164580__F1 Neuronal dysfunction in HIV-associated neurocognitive disorders CXCR4 SRC RAC1 CXCL12 PMC4277124__F12 Proposed underlying mechanism for the effect of SCE on drug metabolizing enzymes and drug transporters via Nrf2-mediated signaling pathway MAF GCLM GSTA4 KEAP1 NQO1 PMC11003951__F8 Inflammatory Factor IL1A Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway IL1A PMC8825588__F2 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment LIMK1 APC MYC PTEN CTLA4 MTOR ATM BCL2 ATR ARF6 FADD TF BAX PMC12222815__F7 GCRSZXD- Chinese herb - active ingredient - hub gene - signaling pathway – disease network GC EGFR SRC PMC8825588__F5 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment TLR4 NRP1 MSC PMC4367656__F1 Physiological changes with aging () IGF1 PTEN MTOR SIRT1 PMC8164580__F2 Neuronal dysfunction in HIV-associated neurocognitive disorders MDM2 SRC IL1B PMC4592361__F7 Involvement of LRP6 in the PTH-stimulated anabolic bone effect SOST LRP6 PTH PMC8072315__F1 Major signaling pathways and key mediators of macrophages in acute kidney injury TLR4 EPO SYK JAK3 PTEN MTOR STAT3 PMC7059563__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.A KEGG pathway analysis revealed 15 substantially enriched pathways corresponding to transcripts dysregulated after spinal cord injury (SCI) CASP3 TRADD LIF IL6 TNF PMC4278302__F6 Acellular fraction of ovarian cancer ascites induce apoptosis by activating JNK and inducing BRCA1, Fas and FasL expression in ovarian cancer cells BRCA1 HEL-S-162eP PMC8566438__F1 Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years AIP AHRR AHR SRC PMC9112604__F3 Endotheliitis, Shunts, and Ventilation–Perfusion Mismatch in Coronavirus Disease 2019: A Literature Review of Disease Mechanisms FURIN ACE2 TMPRSS2 PMC8083806__F2 An update on genetic basis of generalized pustular psoriasis (Review) CTSG CXCL1 IL36RN MPO AP1S3 CXCL2 STEAP4 MYD88 TNF CARD14 PMC2783576__F2 Mitotic removal of cohesin in humans: In humans, cohesins (pink) are removed from chromosome arms in prophase in a Plk1-dependent pathway PLK1 SMC3 APC PMC6523301__F1 Main cellular protein clearance mechanisms, the ubiquitin–proteasome system (UPS), and the autophagy pathway ATG12 ATG3 RPN2 ATG10 ATG14 DKFZp686F0183 RPN1 PMC5823444__F8 Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen ChAT IL1B PMC3942890__F1 ER stress signaling pathway ATF4 EIF2A PMC9424857__F1 Entner-Doudoroff pathway in Synechocystis PCC 6803: Proposed regulatory roles and enzyme multifunctionalities PROC TNLG7C HPR HEL-S-162eP PMC11560437__F4 Aquaporins in sepsis- an update AQP3 AQP1 SP1 AQP9 PMC6498404__F4 High-affinity IgE is derived from the CD80+ pro-PC subset of IgG1 memory cells in mouse memory responses PC BACH2 GC FOXO1 BCL6 PMC5705153__F8 Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10 FADD PMC5207552__F1 Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin–Beck disease CASP6 BAD HIPK2 RASD1 BAK1 POSTN CDC37 BCL2L1 BCL2L11 FZD1 IGF1 BIK GSTT2 IGFBP4 IGFBP2 BCL2 MCL1 BAX PMC11488446__F2 Alterations in the WNT/PCP Signalling Pathway During the Progression of OA DAAM1 DVL2 ARHA SCRIB RAC1 CELSR1 CELSR3 VANGL1 DVL3 FJX1 DVL1 PMC9025114__F3 Selectin-Mediated Signaling—Shedding Light on the Regulation of Integrin Activity in Neutrophils SCAP2 BTK SRC SYK PLCG2 RAC1 PMC8463915__F2 Diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation EGF TLR4 EGFR STAT3 PMC7205878__F2 Autophagy and microbial pathogenesis ATG16L1 ATG12 ADAM10 DKFZp686F0183 MLKL PMC4986634__F7 Mechanism of hepatocarcinogenesis promotion via HBV-induced ROS accumulation SOCS3 CCND1 STAT3 PMC3527322__F1 Amniotic fluid stem cells to study mTOR signaling in differentiation TSC2 RICTOR ULK1 TSC1 GRB10 HIF1A MTOR DEPTOR IRS1 SGK1 RHEB MLST8 PMC8198588__F2 Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis ST8SIA5 CER1 B4GALT5 FUT1 GBGT1 ST8SIA1 A4GALT B3GNT5 B4GALNT1 ST6GALNAC4 GAL ST3GAL1 B3GALT5 ST3GAL5 PMC3726008__F5 Dose-dependent MeHg-induced gene expression alterations within the Wnt-signaling pathway ROCK2 TBL1XR1 TBL1X APC GSK3B LRP5 LRP6 SKP1 ARHA CELSR1 RBX1 FZD1 DAAM1 LEF1 BCAT1 PSEN1 CHD8 hCG_2014051 SFRP1 CSNK1A1 PMC8210554__F3 Circular RNAs as novel potential biomarkers for pancreatic cancer COL1A1 PMC5423134__F9 Proposed mechanism of action by the combination of VCP inhibitors and ER stress‐prolonging agent Salubrinal ATF4 EIF2A VCP PMC3586206__F1 Schematic summarizing the effects of MIF on the canonical MAPK pathways CXCR4 CD74 PMC7011147__F2 Interactions between cells in the tumour microenvironment EGF PMC3289531__F2 A, Hepatic BCAA metabolism HEL-S-62p CS LPL HEL-S-70p MTOR TG IRS1 PMC5938061__F7 Gastrin-CCKBR–GA12/13–RhoA–ROCK signaling in pancreatic cancer HEL-S-11 CCKBR PMC12033294__F7 MAPK signalling pathway (KEGG:04,010, 31 counts; https://www NF1 CD14 NLK EGF MAX FLNA GRB2 ECSIT MIP TNF MEF2C MPL PMC8406585__F10 TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage NLRP3 IL1B GSDMD PMC12033294__F8 cAMP signalling pathway (KEGG:04,024, 7 counts; https://www NPY GIP OXT GAL VIP CFTR PMC7555106__F3 MDSC-mediated events in intestinal epithelial dysplasia S100A8 MYC S1PR1 PMC3458425__F6 Docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and 16O/18O labeling SV2B EGR1 CDK5 CREB1 YY1 PMC8243426__F1 Phase II study of the PI3K inhibitor copanlisib in combination with the anti-CD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: treatment rationale and protocol design of the COUP-1 trial BTK BCR LYN SYK MTOR PMC3861642__F9 Genes in the insulin signaling KEGG pathway that are directly or indirectly regulated by EBF1 PIK3CD PIK3R1 SOCS3 PHKA1 PRKAR1A PHKA2 PRKAA1 PYGB FLOT1 ACACB PRKAG1 HK2 PRKAB2 PRKAB1 FBP2 SOS2 EIF4E HRAS CRK PIK3R3 IRS1 RHEB TSC2 PIK3R5 PPP1CC HEL-S-80p TSC1 GRB2 PRKAG2 SHC4 AKT3 BAD PDK2 INS PFKM MTOR INSR PHKG2 SOCS4 PFKP ARAF IRS4 PRKAA2 FBP1 GYS1 FLOT2 HEL-S-42 PIK3CA RAF1 SOCS1 PMC7004076__F4 Molecular mechanisms of YQCT RARA FGF10 MTOR FGFR2 TLR3 PMC8659262__F1 Co-Production of Isoprene and Lactate by Engineered Escherichia coli in Microaerobic Conditions MVD MVK IPP PMC7799400__F1 COVID-19 pathogenesis and MSCs role in the elimination of SARS-CoV-2 related complications (1) SARS-CoV-2 enters alveolar type II cells through binding ACE2 HGF IGF1 MSC ACE2 CFTR PMC6367542__F6 Proposed mechanisms of adiponectin-induced growth inhibition of pancreatic cancer ADIPOR1 ADIPOR2 GSK3B TCF7L2 PMC1603434__F6 TSC1/TSC2 in the canonical Beta-catenin signaling pathway TSC2 FRAT1 PMC6302460__F3 Comparison of four TPs in breast cancer subtypes TSC2 BAD TSC1 GRB2 RXRA PMC4783948__F5 Highest-scoring and fifth highest-scoring pathway maps for the last two time points post-TBI (24 and 72 h) CCNA2 PLK1 ATF2 GSK3B RALA RHO CDC34 PDPK1 CDK6 ATM MDM2 CCND1 CDK4 CDC2 ROCK2 LIMK2 SKP1 HRAS RBX1 PAK1 CDK2 RELA TOB1 ATR SKP2 RGL2 CDC42 STAT3 PMC4075129__F3 Molecular targets based on the predominant PI3K/AKT/GSK-3B pathway GSK3B BDNF PMC4075129__F1 PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease GSK3B CDK5 BDNF PMC3573419__F1 Germinal-center B-cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) derived from normal germinal-center centroblasts ING1 MDM2 BCL2 PTEN MTOR PMC4137950__F1 Human respriatory syncytial virus (hRSV) recognition by airways epithelial cells: upon infection, different hRSV components activate pattern recognition receptors (PRRs) CD14 TLR7 TLR4 CXCL10 IRF3 CCL5 MYD88 IL1B NOD2 TLR3 MAVS PMC7655645__F3 Protein interactions associated with signaling pathways enriched in diabetes mellitus-associated coronary heart disease ZDHHC14 INA RTKN CTSF RBM4B PCNT C1QTNF6 DAG1 ATXN10 CTSW CDCA4 CACNA2D2 PDZD4 PTRH1 GNGT2 PMPCA COPS6 DMAP1 ZAP70 NKG7 CCDC107 GNAS KCNE4 TSEN54 DUSP2 NUDCD3 RAB11FIP5 B3GAT1 PVRIG GLS ZNF76 WDR54 GZMH PMC2727431__F1 Various states of pluripotency SOX2 LIF KLF4 PMC4524600__F6 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish MLNR OXTR GRPR PRLR KISS1 GHR CALCR BDKRB2 SSTR2 LTB4R PMC6277997__F6 Mechanisms of DMTN in the invasion and metastasis of CRC PAK1 DMTN ARHGEF2 RAC1 PMC4524600__F5 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish CSF1R TLR4 BCR KITLG SYK CDC37 PTEN RAC1 CD19 PMC4414328__F8 We propose three possible pathways that could lead to liver NKT cell anergy WNT3A GSK3B PMC3573419__F2 Activated B-cell-like (ABC) diffuse large B-cell lymphomas (DLBCLs) are derived from plasmablasts that are characterized by a block in differentiation NFATC1 MYD88 MTOR CD79B CD79A BCL6 BTK CARD11 BCR SPIB BCL2 SYK STAT3 PMC8159877__F4 Changes associated with IMR in the anterior leaflets at 4 weeks post-MI within the TGFB signaling pathway BAMBI GIG8 SMAD2 TGFBR1 SMAD6 SMAD4 TRAF6 ARHA MAP3K7IP1 SMAD1 DKFZp781O1323 IFNG PMC4720912__F2 Insulin signaling pathway TSC2 BAD TSC1 GRB2 RHEB INSR PMC4945843__F1 Major cholesterol metabolism pathways in the liver ABCG1 LDLR ABCA1 HMGCR CYP7A1 FASN PMC9444456__F2 Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain CXCL1 IL8RB TNF BDNF PBR PMC11641026__F4 Biosynthesis of aminonucleosides CSTA CSTB PMC4325931__F6 Overlay of gene expression on the p53 signaling pathway PERP SFN APAF1 MDM2 CDK4 PIGS BAX PMC5088662__F5 Schematic diagram elucidating signalling pathway of TLR4 and TLR9 responsible for GFNs-induced cytotoxicity TLR4 TLR9 TRAF6 MYD88 IL1B PMC8549894__F2 Pathophysiology of Exercise-Induced Muscle Damage and Its Structural, Functional, Metabolic, and Clinical Consequences PIKFYVE RAC1 PMC5350147__F1 Akt/mTOR signaling schematic NF1 TSC2 TSC1 PTEN EIF4E RPS6 MTOR IRS1 PMC9314012__F2 Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis TLR4 TGFBR2 MYD88 IRS1 IL1B PMC6617469__F4 Expressional change of genes for the central carbon metabolic network in Kmmig1 ACAD11 GPD2 RAG2 MDH2 PMC3540890__F1 Biosynthetic pathway of prostaglandins COX2 GHB2 COX1 PMC5335622__F2 Theoretical concept of combined application of checkpoint blockade therapy and DGK-inhibition LCK ZAP70 IFNG PMC3084054__F1 Synthesis-enabled functional group deletions to probe predicted intermolecular interactions involving the C41 carboxylic acid and/or the C19 mycosamine appendages of AmB TES NAT2 LBH PMC3822825__F2 E2F1-induced apoptosis ATM APAF1 MDM2 ATR PMC6885770__F1 Nrf2/HO-1 pathway MAF KEAP1 RBX1 PMC8843872__F1 Ferroptosis: An emerging therapeutic opportunity for cancer GPX4 LPCAT3 FACL4 SLC7A11 SLC3A2 PMC5088662__F4 MAPKs, TGF-beta and TNFA dependent pathways involved in GFNs toxicity SMAD2 SMAD4 TNF BAX PMC4925704__F2 Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives EGFR FADD STAT3 PMC3069932__F9 Proposed role of Nodal in human placental development and mechanism of Nodal-regulated trophoblast invasion MMP2 NODAL SMAD2 PMC3836323__F2 Vascular smooth muscle cells mechanotransduction mechanisms in stretch-dependent interconnected signalling IGF1 ARHA RAC1 PMC4268999__F2 PI3K/Akt signalling pathway TSC2 BAD MDM2 BCL2 PTEN MTOR PMC4268999__F1 Wnt/Beta-catenin pathway APC GSK3B TEF MYC LRP6 PMC10958678__F7 P53 and mut‐p53 in the TME during cancer development ISG15 ULBP2 PMC4461458__F2 Prevalent mutations in acute myeloid leukemia (AML) potentially affect HIF levels in cancer cells MDM2 VHL HIF1A MTOR PMC10958678__F6 Functional activities of mut‐p53 in cancers PML E2F4 SLC7A11 EGFR SMAD2 PTEN GPR49 MAP2K3 DICER1 NR1i1 TOPBP1 ATF4 BTG2 ETS2 CCNE2 SOX2 MAFF CD44 ARHA BRCA1 FOXO1 TK1 KLF17 CASP3 CXCL12 SLC25A1 PCNA TCF4 FOXH1 PMC6682527__F4 KLF5-targeted genes in the pancreatic cancer pathway EGF BAD POLK SMAD2 EGFR KLF5 SMAD4 RALBP1 MTOR E2F3 BRCA2 E2F2 RAD51 JAK1 TGFA STAT3 BAX PMC9514046__F2 Interleukin 22 and its association with neurodegenerative disease activity CXCR3 PDC CCR6 CCR10 LIF CCR4 PMC8685420__F3 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer ANGPT2 PLAUR FOS VEGFA CDKN2A ITGAM CDKN1A NFKB1 ERBB2 MDM2 BCL2 THBS1 ITGAV JUN TGFBI PMC5987683__F3 Mitogen-activated protein kinase signalling pathway CD14 EGF BRAF NGF MOS FOS ATF2 MYC TRAF6 TNF MAP3K7IP1 HEL-S-102 NLK NFKB1 ATF4 ECSIT CSA2 TRAF2 MEF2C JUN PMC7526126__F3 InterferonG mediated cancer regression CASP3 SLC7A11 VEGFA CASP9 SLC3A2 HIF1A EN1 CASP8 PMC7399975__F6 Tec kinase signaling and FAT10 pathway BTK FOXO3A GNG2 TEC SRC SYK FADD PMC7526126__F1 InterferonG signaling STAT1 JAK1 MTOR IRF-1 PMC8557551__F6 Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy RUNX2 COL1A1 CYP27B1 PMC3179548__F2 PE intoxication pathway LRP1B EEF2 CD22 FURIN PMC8909190__F2 Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery APP GAL TARP PMC7748976__F1 Interaction of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus with the renin-angiotensin system and phagocyte activation cascade TNF ACE2 PMC4811771__F16 SLE risk haplotype upregulates the antigen presentation pathway (APP) AOAH APOM DKFZp666G145 CUEDC2 CFB RPS6KA1 SQSTM1 RNF114 TRIM56 ZNF143 B9D2 IRF4 PMC9249764__F4 Effect of VEN incubation on gene expression of apoptotic signaling cascades in SEM (upper panel) and RS4;11 cells (lower panel) BOC IGF1R IKBKG CHUK BAD TRADD MAP2K4 MYC BCL2L1 CASP2 BCL2L11 MDM2 IRF4 IRF2 BAX HELLS MAP3K1 IRF7 IGF2 IRF3 TNF DIABLO BCL2L2 IKBKB TNFRSF25 BIRC2 NFKBIA LTA NFKB1 RELA TNFSF10 PMAIP1 TNFRSF21 TNFRSF18 BCL2 MCL1 TRAF2 FADD CYCS NFKBIE BOK PMC8609049__F1 “Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging MTR MTOR HEL-S-133P LAT HK2 GLS PMC2600878__F6 Syk signaling is necessary for E-selectin-induced LFA-1-ICAM-1 association and rolling but not arrest CXCL1 IL8RB SYK PMC2843172__F8 Schematic drawing summarizing the signaling pathway downstream from CB1 receptors in cerebellar granule cell precursors GSK3B CCND1 PMC12121766__F2 Sites of activity of genes encoded by SNPs observed to be associated in our study in the NO signaling pathway downstream of Cit KCNMB4 PRMT6 ADCY8 PDE9A PMC4963810__F2 Comparison of the Drosophila and vertebrate non-canonical Wnt pathways applicable to this proposal MCC WNT4 ARHA WNT5B PMC4546915__F1 Adaptive stress signaling in targeted therapy resistance in cancer TBK1 BAD RALA RALB PTEN TBC1D4 IRS1 PDPK1 TSC2 TSC1 MDM2 GRB2 CDC42 PMC2922838__F2 Gene expression profiling in whole blood of patients with coronary artery disease CASP3 ZNF183 NDUFB3 CAD PMC7137347__F1 LncRNA in regulating stem cell pluripotency SOX2 NODAL SMAD2 SIRT6 SMAD4 PMC5460107__F2 FLT3 signaling pathway GRB2 FLT3 MTOR PMC5247290__F3 TGF-b/BMP signaling pathway in osteoblast differentiation RUNX2 SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC4415606__F4 Arginine deiminase (ADI) hydrolyzes arginine into citrulline MTOR ASL BAX PMC5247290__F2 Canonical Wnt/b-catenin signaling pathway APC GSK3B LRP5 LRP6 PMC12205714__F8 The potential protective mechanism of BJOE in irinotecan-induced delayed diarrhea mice TBK1 CGAS IRF3 PMC11354818__F12 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice BIN2 ABI2 EBF2 TF PMC11354818__F14 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice CYP3A4 CYP1A2 CYP2E1 PMC8582658__F1 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 PMC3736482__F3 Associated intracellular cascades to physiopathology of vascular remodeling IGF1 VCAM1 EGFR SRC PMC8872751__F6 Transcriptome analysis reveals transforming growth factorB1 prevents extracellular matrix degradation and cell adhesion during the follicular-luteal transition in cows EGF SDC1 CLDN1 ESAM COL1A1 TGFB1 PMC8817718__F3 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis NLRP3 TLR4 TLR9 PMC8817718__F2 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis NLRP3 SYK MYD88 STAT3 PMC8724844__F7A Cellular RhoA Functions by the Integrated Application of Gene Set Enrichment Analysis STX7 STX6 STX18 VAMP4 STX2 VAMP5 VAMP1 SNAP29 SNAP23 STX5A YKT6 BET1 USE1 VAMP2 VAMP3 STX4A STX11 STX16 STX3A STX17 VAMP8 STX8 VAMP7 PMC6887687__F1 Main signalling pathways of programmed necrosis in cardiomyocytes KL TRADD CYLD TRAF2 FADD MLKL PMC2844426__F4 Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) NF1 GRB2 RAF1 PTPN5 PMC8582658__F6 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 PMC8582658__F5 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 PMC8582658__F3 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions PDK2 LRP5 CCND1 LRP6 HEL-S-133P STAT3 PMC8582658__F2 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions PIN1 APC GSK3B LRP5 LRP6 HEL-S-133P PMC5341220__F2 Canonical signalling pathways activated by the EP receptors EGR1 ARHA PMC5516996__F3 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder TSC2 SIAH1 PERP ATM CDK2 MYC MDM2 ATR RFWD2 PMC5516996__F5 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder E2F4 ORC6 SMAD4 DBF4 ORC3 CDK7 CDC45 ORC2 CDC20 SMC3 CDK2 ORC1L PCNA SKP2 MYT1 PMC4266525__F1 Pathway for corticosteroid synthesis in the human adrenal gland HSD11B2 HSD11B1 CYP11A1 HSD3B2 STAR CYP11B2 PMC11522771__F2 Signaling pathways involved in cardiac fibrosis BMP2 SMAD2 SMAD6 SMOC1 SMURF1 PMC2852570__F1 Semaphorin signaling GSK3B EVL RHO PMC8615192__F5 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells TSC2 BAD FAR1 BCR SYK PTEN GAL RBL2 RXRA CD19 PMC8615192__F4 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells VASP BAD HEL-S-28 GRB2 SHE CRK JUN PMC8615192__F7 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells PROC CAD OTP LAT PMC8615192__F6 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells NLK ATG12 ATM CDK2 MDM2 CYC1 INS KLF2 PTEN SKP2 INSR BOK PMC4644734__F1 Steps in the macroautophagy pathway ULK1 ATG16L1 MTOR ATG14 PMC3617041__F6 TGFB restoration by SMAD6 knockdown SMAD2 SMAD6 PMC7056928__F4 Cholesterol auxotrophic lymphomas accumulate squalene, an antioxidant-like metabolite SQLE GPX4 ALK SLC7A11 FDFT1 LDLR GLS PMC8444957__F1 Advances in research on pharmacotherapy of sarcopenia FST ACVR1 IGF1 SMAD2 SMAD4 SRC MSTN MTOR ACE2 PMC1601946__F1 E3 ubiquitin ligases regulating the TGFB signaling pathway APC SMURF2 SMAD4 WWP1 SMURF1 ITCH PMC8615192__F1 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells BAMBI FST E2F4 NODAL SMAD2 THSD4 SMAD6 SMAD4 SKP1 ARHA THBS1 RBX1 PMC8615192__F3 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells DKFZp666G145 E2F4 CD6 SMAD2 GSK3B SMAD4 STAG1 DBF4 ORC3 CDK7 STAG2 CDC45 ORC2 MCM3 PI3 MCM2 SMC3 CDK2 CD7 MDM2 RAD21 PCNA SKP2 PMC8685420__F8 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer PLG ARHA SERPINB5 RHO PMC8615192__F2 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells CD47 CD44 VWF CHAD DMP1 CD36 PMC9335949__F7 Explore the Potential Ingredients for Detoxification of Honey-Fired Licorice (ZGC) Based on the Metabolic Profile by UPLC-Q-TOF-MS GSTM2 CYP2C9 CYP1B1 GSTT2 GSTM1 HEL-75 HEL-S-22 PMC11662066__SF3 Clinical pathway, Cohort II CRP MCU PMC3292309__F3 Activation of inflammatory mediators in pancreatic Beta-cells in type 1 diabetes STAT1 IL18 TRADD MYD88 TRAF2 PMC8940899__F7 MiR-323a-3p inhibits gefitinib resistance acquisition by targeting ErbB3/PI3K/Akt-EGFR/Erk1/2 signaling in colorectal cancer ERBB3 EGFR GSK3B PMC2850427__F2 Simplified Overview of the Purine Metabolism PathwayThe scheme is derived from KEGG Pathways hsa00230 (purine metabolism) and hsa00240 (pyrimidine metabolism) ADA UMPS PNP PMC5673628__F12 Schematic summary of baicalin-driven regulation of autophagy and inflammation during Mtb infection NLRP3 IL16 MTOR PMC10388552__F6 Aberrations in ion channels interacting with lipid metabolism and epithelial–mesenchymal transition in esophageal squamous cell carcinoma PDGFA LIF EGFR OSM INSR PMC7960610__F2 Schematic presentation of common molecular genetic aberrancies in parathyroid adenoma (PA; left) and carcinoma (PC; right) RET APC JUND PMC2879972__F4 Illustration of different mechanisms of MUC1 and MUC4 for the repression of apoptosis MUC1 MUC4 ERBB2 FGFR3 FADD PMC8216764__F1 Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity RICTOR ILKAP LIM2 TLR4 NCK2 HEL-S-28 GSK3B SRC PTEN TNF PMC3412266__F1 Atypical PKC signaling pathways leading to lymphocyte activation and/or differentiation BCR NFATC1 RELA TRAF6 PMC1891745__F1 Diagram illustrating Functional JAK STAT PathwayThis “JAK STAT” pathway appears to be ubiquitous amongst vertebrates EPO GRB2 PMC5120225__F2 Signaling pathway of liver fibrogenisisThe injured liver produces various cell factors, which can activate transforming growth factor beta (TGFB) and platelet-derived growth factor beta (PDGFB), and bone morphogenetic protein (BMP) SMAD2 PMC3584306__F3 Obesity Pharmacotherapy: Current Perspectives and Future Directions CRH MC4R TRH ARC SIM1 PMC5812347__F2 Biochemical, Cell Biological, Pathological, and Therapeutic Aspects of Krabbe Disease IGF1 PMC2742785__F8 Cluster 2 genes significantly overlapped with those in the eicosanoid signaling pathway (P = 4.6E-05) PLA2G2E PTGS2 PLA2G2C LTB PLA2R1 LTB4R PLCB1 HEL-S-22 GSTZ1 PLA2G3 PLA2G5 TBXA2R PLA2G2F ALOX12B PMC2607021__F4 Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease NUMB ZFHX3 CAMK2D CAMK4 FGF10 LNX1 LNX2 CAMK1 PMC5558921__F2 BER pathway is essential in the nervous system FEN1 POLE LIG1 PNKP PCNA TDP1 PMC11900433__F11 Unfolded protein response (UPR) pathway ATF4 TRAF2 XBP1 PMC8678597__F1 Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production TBK1 CGAS IRF3 PMC7435717__F5 Effect of Icariin, Purmorphamine, U0126, and PD98059 on osteogenic signaling pathways RUNX2 SMO BGLAP PMC10376516__F4 Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics MTOR BAX PMC6991638__F7 Inhibitory effect of WKYMVm on osteoclast formation and bone resorption activity CD9 FPR2 STAT3 PMC8120466__F6 MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer EGF MUC3A EGFR PMC8902048__F1 Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility ATF7 ATF5 MTOR PMC4051228__F1 The folate/Hcy metabolic pathway RFC1 MTR DHFR MTRR TYMS PMC5734931__F2 Formation of autophagasomes in autophagy ULK1 ATG12 ATG3 ATG10 DKFZp686F0183 PMC4622843__F4 Interaction network of differentially methylated diabetic genes EGF COL1A2 MYC FBN1 TNF SERPINB2 TGFB1 LAMA3 COL4A2 PMC5065302__F6 Mechanisms through which rolipram (ROL) attenuates pain behavior in bone cancer pain CCR2 PDE4B CCL2 IL1B PMC5920380__F1 Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway KIF7 SUFU GLI3 GSK3B SMO SPOP PMC4348071__F1 Exploiting the head and neck cancer oncogenome: Widespread PI3K-mTOR pathway alterations and novel molecular targets NOTCH2 NUMB EGFR TP63 PTEN MTOR CDKN2A FAT1 RHEB TSC2 RICTOR TSC1 RPS6KB2 NOTCH1 PIK3CA CCND1 PMC3669657__F6 Observed effects of Hedgehog and Wnt inhibition, and Sox17 overexpression in HOG cells DHH IHH SUFU LRP5 SHH CCND1 LRP6 SFRP1 SMO SOX17 TCF4 PMC3310485__F4 Schematic of the role of BDNF in the brain reward pathway associated with addiction TH BDNF PMC3408604__F1 Cardiac myocyte signaling coupled to phosphodiesterase (PDE) 5 TRPC6 GATA4 PMC9136126__F6 Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model CCL11 SLC27A2 FABP6 CCL25 NR1H3 BAX PMC4526101__F3 The type I diabetes mellitus pathway in which HLA-A, HLA-B, HLA-C, HLA-DPB1 and GAD1 are involved INS IL2 PRF1 CD80 IFNG PMC3390457__F1 Neuroprotective signaling pathways employed by Erythropoietin EPOR EPO PMC3514635__F4 Intracellular trafficking proteins involved in CMT neuropathy FGD4 MPZ MFN2 SH3TC2 EGR2 FIG4 MTMR2 PMP22 PMC4526101__F2 The systemic lupus erythematosus pathway in which HLA-DPB1, HIST1H4J, HIST1H2BO, H3F3C, H2AFY, H3F3A, HIST2H3D, HIST1H4D, HIST2H4B, HIST1H2BL and HIST1H4K are involved IL10 TH CS BCR SARNP APC MAL PMC11058998__F4 Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors SMAD2 MCU LATS1 RAB5C MTOR LATS2 PMC11058998__F3 Piezo1 affects the occurrence and development of diseases through multiple signaling pathways NLRP3 PIEZO1 MTOR PMC2287275__F2 Mesenchymal stem cell dysfunction in HGPS HES5 HEY2 HES3 MSC HES1 BOK PMC6651655__F3 Representation of S100B effects on Caco-2 cells MTOR S100B ELL PMC11854313__F2 Biosynthetic pathway of terpenoids STS MVK IPP PMC7256186__F1 Warburg effect in melanoma cells caused by BRAFV600E mutation leading to constitutive activation of MAPK pathway MYC ENO1 HK2 HEL-S-68p PMC7513299__F1 Adipocytes in EOC metastasis HGF IGF1 CD44 PMC11612565__F4 Mechanisms of EC pyroptosis in sepsis NLRP3 HMGB1 CGAS TLR4 IL33 DEFA1B DEFA3 GSDMD PMC11612565__F3 Specific pathophysiological mechanisms of EC apoptosis in sepsis PIM1 ROCK1 TUG1 SERP1 SLIT2 MTOR NRP2 SSH1 STAT3 BAX PMC11612565__F6 Relationship of EC autophagy and function and EC autophagy-related mechanisms in sepsis NLRP3 NAMPT RUNX2 PTBP1 MTOR CD74 APOL1 SIRT1 SKP2 PMC11612565__F5 Mechanisms related to ferroptosis of ECs in sepsis GPX4 SDC1 STEAP1 KEAP1 NOX4 ATF3 GDF11 IGF2BP2 SIRT1 PMC10865661__F15 Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IKKB/NFKB p65 signaling pathway: insights from in silico and in vivo investigations COX2 BAD DAO CDC42 PMC8088756__F2 Demyelination as a result of an immune response in patients with COVID-19 CD14 IRF3 MYD88 PMC4445098__F6 Network between MAPK signaling pathway-related genes and miRNAs FGFR3 RRAS CACNB3 FLNB MAP3K12 MAP3K7IP1 CACNA1A TAOK2 HEL-S-102 DKFZp686L0365 TNFRSF1A MAP3K14 TGFB1 CACNB1 PMC5387690__F7 A Caenorhabditis elegans Genome-Scale Metabolic Network Model MAX MALL FH PMC9227929__F2 Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases IDO1 GIG8 IDO2 PMC8447597__EV3 Drugs targeting SARS‐CoV‐2 and host protein interaction DDR1 FLT4 GSK3B SERPINB5 SORD PRIM2 PRIM1 RPL19 RPL23A A2M POLA1 POLA2 GUCY1B1 CDH2 SLC5A2 PPIH COL18A1 MVK DIABLO PCMT1 RPS13 APOB VAMP2 DHFR HEL-S-271 HEL-S-72p IGF2R RPS6KA6 AKT3 ATP5PO RPL26L1 EGFR HEL-S-7 ATP5F1D ERBB4 RPS2 RDH12 RPS6 PHB2 PYCR2 SKP1 RPS8 RPS9 DCD RPS17 BMPR1A ERBB2 TPD52L2 RPL10 PMC9694790__F2 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases TRAF6 MYD88 IL1B PMC9694790__F4 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases CDK2 BCL2 GADD45A CDK4 CDK6 BAX PMC8197962__F1 ZNF-281 as the Potential Diagnostic Marker of Oral Squamous Cell Carcinoma MMP9 GPR49 SOX4 PMC7345850__F9 Left panel: Balanced autophagic flux LRRK2 M6PR SQSTM1 PMC11612565__F2 Effect of DAMPs on vascular ECs during sepsis or severe bacterial infections NLRP3 HMGB1 PMC8958883__F1 Wnt/Beta-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma APC GSK3B AXIN1 LRP5 LRP6 PMC6907065__F2 The mechanism of UVA-modulated HO-1 regulation through the PERK and Nrf2 signal pathway KEAP1 ATF4 EIF2A PMC8944161__F1 Clinical benefits of PD-1/PD-L1 inhibitors in patients with metastatic colorectal cancer: a systematic review and meta-analysis APC LCK ZAP70 IL2 CD80 LAT PMC11671274__F1 Intestinal changes in T2DM PYY MYD88 IL1B IFNG PMC4773818__F6 Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention SMAD2 TGFBR1 TGFBR2 ARHA PMC5790278__F7 Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma SOCS3 MTOR STAT3 PMC7708728__F1 Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors KMO CRP TNF PMC6086625__F5 Kinases associated with the CX3CL1/CX3CR1 axis ITGB3 EGFR PTK2B SRC PMC11513491__F3 Schematic illustration proposed for the probable role of PI3K axis in AML cells PTEN MTOR PMC4151374__F2 Interaction network using Pathway studio PLG PRND VPS54 SPRN KLKB1 TNF LAMA3 APOE PRNP PMC4151374__F1 Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation PLG GRB2 NRXN2 KLKB1 FRS3 LAMA3 APOE PRNP PMC4334309__F2 Directed evolution of the nonribosomal peptide synthetase AdmK.Notes: Andrimid is biosynthesized by a hybrid nonribosomal peptide synthetase/polyketide synthase pathway TG ADM PMC7836194__F2 Curcumin mediates miRNA regulation in PC FOXD3 ATG2B CCND1 CDK4 PTEN DNMT3B PMC3875780__F3 Human intestinal innate myeloid cells CD14 TLR5 TLR4 IRF4 PMC6315509__F1 Notch and Wnt signaling pathways GSK3B LRP5 LRP6 PMC7356262__F8 Canonical pathway “Osteoarthritis Signaling” for Epi C vs HMGB1 MMP10 NAMPT RBPJ HDAC3 MMP9 SMAD4 DLX5 HES1 MTF1 TIMP3 SP1 SP7 PMC7356262__F7 Canonical pathway “NF-kB Signaling” for VA vs EGF NGF TRADD HEL-S-71 RELB PLCG2 MYD88 PELI1 MAP3K7IP1 UBE2V1 LTA RELA LCK CD40 REL TGFA FADD TIRAP TAB3 PMC4661887__F4 Mechanism of action of soy peptides in HepG2 cells RICTOR LDLR MTOR PMC7356262__F6 Canonical pathway “Osteoarthritis Signaling” for VA vs HMGB1 MMP10 NAMPT HDAC3 BMP2 SMAD4 COL2A1 SP1 SP7 SOX9 PMC3461959__F3 Blastocyst Lineage Segregation and Stem Cells SOX2 GATA6 SOX17 GATA4 PMC4465084__F1 Investigational approaches targeting the factors contributing to celiac disease pathogenesis HLA-E MICB APC MICA TNF PMC9097215__F2 Tumor Suppressor Kinase LKB1: Metabolic Nexus PDC ENO1 HIF1A HK2 PMC8064323__F10 Gene clusters annotated to drug addiction pathways in HIV+ prefrontal cortex and the effect of Meth use PDE1C PIK3R1 PDE1B TPH1 CACNA1B PDE4A GRIN3A TPH2 MAOA DRD1 GRIK3 PAH SYNGAP1 CACNA1A DLG4 CACNA1C GRM2 GRIN1 FOSB GABRA2 DAB1 CREB3L4 RELN ADCY1 HOXA4 GRIA3 ADRB2 PDE1A GRIA2 ADCY3 GABRA4 GABRG3 GABBR2 GABBR1 SLC18A2 GRID2 GABRE ADCY6 GRIA4 GRIN2B ADCY5 HTR2A GUCY2D PPP2R5D GABRG1 PDE7B ADCY9 TH GRIK5 LRP8 SSR4 GRIN3B D4S234E CACNA1S GABRB3 KCNJ6 CALY PTPN5 CAMK2D OPRM1 CHMP5 GRIK2 ADCY8 CACNA1F CANX GABRB1 GRIK1 CALML3 CAMK2A GABRA3 CHRNB2 PMC7867092__F2 Leptin-promoted lipid metabolic reprogramming in cancer cells STAT3 CD36 PMC3707630__F7 CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex CD44 CCND1 SRC RHO CD74 PMC9133699__F9 Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems HP APC MAL PMC8380940__F1 Engineering Biological Electron Transfer and Redox Pathways for Nanoparticle Synthesis MAX PMC6506734__F1 Downstream signaling pathway of adiponectin SP1 NR1C1 APPL1 PMC6952810__F2 MicroRNAs regulating key genes of the TGFB signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 TF PMC5085112__F7 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease ABCB4 ABCG5 LDLR ABCB11 HMGCR PMC5364554__F9 Acceleration of bone regeneration by activating Wnt/Beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis RUNX2 APC GSK3B LRP5 LRP6 FRAT1 PMC6291520__F6 Graphical summary MTOR DKFZp686F0183 PMC5962649__F4 Historic and updated model of IRS signaling RS1 RICTOR SOCS3 AHR CUL7 GAB2 FES GRB2 GRB10 IRS1 PMC12137631__F4 Molecular mapping of HFD-induced liver inflammation and metabolic dysregulation HFD induced liver steatosis through activating key inflammatory and lipid metabolism genes PIK3R1 CXCL16 SCD NFKB1 ABCG1 LPL PIK3CA TNF PPARG IRS1 INSR PMC5463358__F3 Microglial M1 and M2 signaling in neurodegeneration, and potential targets for neuroprotection HMGB1 CD14 GSK3B IFNGR2 CCL2 MYD88 IFNG STAT1 COX2 TLR4 SYK TYK2 JAK3 JAK1 ARG1 IFNGR1 PMC3296080__F1 Interactions between insulin-like growth factor-1 receptor (IGF-1R), insulin receptor (IR), and epidermal growth factor receptor (EGFR) signaling pathways BAD IGF1R PDK2 EGFR GRB2 PTEN MTOR IGF2R PMC12137631__F3 High fat diet disrupts Insulin signalling Pathway PIK3R1 PTPN1 PIK3CA IRS1 INSR PMC2241839__F3 Cholesterol biosynthesis pathway HEL-S-62p SQLE EBP SC5D DHCR24 MVK HSD17B7 TM7SF2 GGPS1 HMGCR ACAT2 PMVK GIG8 MVD DHCR7 FDPS PMC8407594__F1 Combined overview of all qualitative Wnt (sub-)models found within the 19 Wnt simulation studies EGF APC EGFR GSK3B LFNG LRP6 HES7 DKK1 AXIN2 SOX17 NKD1 PMC6297716__F4 Scheme illustrating the signaling pathways and transcription factors contributing to SND1 promoter activation SND1 SP1 XBP1 PMC5354998__F10 Integrated genomic and molecular characterization of cervical cancer RAB38 MAPK8 MYC EVPL GCK HIF1A CRKL TRPV1 IFNG ALAS1 NDUFV3 PERP NR1i1 AEN TIMP3 GPX2 KLK3 SHH FURIN MSH2 GREB1 AXL HK2 ALDOB MAPKAPK2 COL18A1 TUBB ABCA3 EIF4G1 RXRA YWHAQ APOB ITGB4 BCL2 COMP CSDE1 BAD PGR SFN SFTPD MAIP1 WWP1 FOSL2 XBP1 UCP2 DKFZp686L0365 RARA FECH FOXA1 SMARCD3 AXIN2 TCF7L1 KRT14 FTH1 STXBP4 NRG1 FOXA2 GIG8 GJA1 ERBB2 STAT4 ADA TFAP2C PMC3248194__F3 RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death PIG59 CYLD TRAF2 FADD PYGL TAB3 PMC6866135__F1 IRAK1 kinase drives distinct prosurvival responses to microbial infection and ionizing radiation PIN1 IRAK1 TRAF6 IRAK4 MYD88 PMC6031874__F1 Simplified scheme of transsulfuration pathway VIT pcap PMC3294197__F3 Ingenuity Pathway Analysis of genes that are differentially methylated (P<1.8 × 10−6) between normal mucosa of cancer patients and controls EGF HNF4A MEPCE HGS IL2 SERTAD3 USHBP1 CCNG2 PTPN22 PMC7085392__F3 Activation of Akt after joining to PIP3 by its PH domain TSC2 TSC1 GSK3B MDM2 RHEB PMC11039944__F2 Alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma AFP EPCAM CXCR4 CD44 PMC6207598__F2 Toll-like receptors (TLRs) and their role in the evasion of the immune response induced by hMPV TLR7 TLR4 TLR9 TRAF6 MYD88 TLR3 PMC7504460__F1 Mechanisms of obesity-induced development of endometrial cancer (EC) ADIPOR1 IGF1R HNF4A IGF1 SHBG PMC8074203__F3 Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights NLRP3 IL18 TLR4 KHK PMC7504460__F2 Insulin-PI3K signaling facilitates cell proliferation and glucose metabolism via serine/threonine protein kinase B (AKT)-dependent and -independent mechanisms TXNIP HEL-S-87p RPS6 MTOR PMC6862746__F9 HCC microenvironment inhibits SIRT4 expression in TAMs and modulates alternative activation of TAMs, which contributes to HCC development SIRT4 ARG1 STAT3 PMC7314952__F3 Ferroptosis, NRF2/antioxidant response element (ARE)–GPX4 pathway GPX4 KEAP1 SLC7A11 PMC11037416__F2 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages RIPK1 TLR4 TRADD RIPK3 RIPK2 TRAF2 FADD MLKL GSDMD PMC11037416__F1 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages ULK1 GPX4 ATG12 LPCAT3 ATG3 ASCL4 ATG101 ULK2 ATG10 MTOR DKFZp686F0183 HEL-S-64p ADA TF GLS PMC11028018__F5 Proposed model illustrating the inhibitory effects of GBE on TGFB downstream signaling pathways SMAD2 COL1A1 PMC7252250__F4 Pathway 1: Insufficient activation of immune response in the middle ear epithelium cells in otitis media TBK1 DEFB4B IKBKE IFNA1 IRAK1 TICAM2 TRAF3 IRAK4 CARD6 MYD88 NOD2 TICAM1 NLRP3 IL18 TLR7 NOD1 BPIFA1 CASP8 JUN IL1B IL1A NLRP1 LYZ IRF7 FOS MAP3K7 IRF3 IFNB1 IL6 TNF TLR3 IKBKB NFKBIA CARD9 NFKB1 BCL2 IFIH1 PYCARD CASP5 MAVS PMC8377014__F1 Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis SET GC PMC4437509__F5 Downstream components of ERK in SCN neurons MTOR PER1 PMC11037416__F5 Pyroptosis mediates macrophage reprogramming of the tumour immune microenvironment NLRP3 HMGB1 TLR4 GZMA GSDMC GSDMB GSDMD STAT3 DFNA5 PMC4437509__F7 JNK MAPK in the circadian clock CRY1 CRY2 PER2 PER3 PER1 PMC4437509__F6 P38 MAPK in the circadian clock CRY1 CRY2 PER2 PER3 PER1 PMC11037416__F3 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages NLRP3 SIRPA CD47 CCR2 TLR4 CXCL10 CCL2 MTOR PMC11993993__F2 LPS proinflammatory signaling pathway CD14 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 IL6 CCL2 MYD88 TNF LBP IL1B TIRAP MAL PMC5346319__F4 p53 dependent and independent tumor suppressive functions of ARF CTBP2 ATM FOXM1 CTBP1 MDM2 ATR WRN BCL6 PMC10957552__F1 Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis GREM1 PTGS2 BMP15 HAS2 PMC11771717__F1 KRAS signaling pathway functions differently in normal cells compared to cancer cells EGFR GRB2 PMC8773878__F5 Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment EGFR CD40 CD80 PMC9636624__F4 Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation UBC PLTP CYP7A1 PMC7570648__F2 Each herb in fighting cancer through oxidative stress pathways PTEN HIF1A PMC3957730__F27 Glycolysis and gluconeogenesis in the mesophilic halophile Haloferax volcanii PTS GIPR KHK PMC8712267__F5 Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 C4BPB F9 ALB EZR RALA ORM1 SERPINA1 HEL114 CDH2 TGFBR3 HEL70 SAA4 HRG ACTG2 CREB3L3 VEGFA GNA13 HEL74 SDC2 GNA11 ARHG WASL ORM2 HEL-S-269 F5 VCAM1 GNB1 SAA2 MYLK CDC42 MYH9 SDCBP EGF MYL6 RHO PFN1 RAMP3 NPR3 CRP RBP4 APOA2 ARHGDIB GNG5 FTL HEL-S-92n S1PR3 RRAS2 PS1TP5BP1 GNG12 HEL111 HP LBP C4BPA GNAS PMC6717289__F6 Our proposed model of KRAS and TP53 oncogenes driving PDAC malignancy via the ARF6–AMAP1 pathway TEAD3 ETV4 EIF4E MTOR ARF6 EPB41L5 MVP RAB11B PMC5948914__F2 Gemcitabine pharmacologic pathway CDA ABCC10 HELB DCTD SLC29A1 CTDP1 SLC28A3 NDP RRM2B POLE RRM1 POLA2 RRM2 POLR2A TYMS ABCC5 ABCG2 SLC29A3 PMC5579704__F3 Proposed mechanisms by which dietary polyphenols inhibit EMT and cancer metastasis EGF HGF PTCH1 SMO PMC9273153__F3 Regulation and Signaling of TGFB Autoinduction FOS SMAD2 SMAD4 ARHA EIF4E MTOR JUN PMC4103658__F7 GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst FGF4 GATA6 PMC4323494__F9 Schematic model for the involvement of TAK1-NLK in IL-1Beta-triggered ATF5 stabilization and C/EBP activation NLK EBP ATF5 MAP3K7IP1 IL1B PMC7438931__F1 mTORC1 pathway and regulation TSC2 ULK1 TSC1 TFEB MTOR DEPTOR RHEB MLST8 PMC9185982__F6 SRF: a seriously responsible factor in cardiac development and disease TRIM32 MYOCD GSK3B KLF4 ARHA TRIM24 RND1 PMC2640456__F1A Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes HMGB1 SCG2 EIF4A1 PPFIBP1 METAP2 DDX3X NEFH EIF4E RPL19 HEL-S-269 PAIP2 AAG1 MAPK1 RPL10A HEL-S-72p PMC6491842__F4 Enriched genes from the ANOVA statistically significant disease status gene list (p-value < 0.05) found in the KEGG Alzheimer's disease pathway (hsa05010) [Kanehisa and Goto, ; Kanehisa et al., , ] SNCA GNE BAD GSK3B RYK TNF CPO CASP3 APAF1 LPL APP CASP9 FADD CR1L PMC4011321__F8 Putative pathway of the inhibition of LPS-activated inflammatory signaling by compound 7 TLR4 IRAK1 ATF2 TRAF6 SYK MYD88 TLR3 PMC7911745__F1 NFKB signaling pathway and the genes associated with BD-like phenotypes RIPK1 TRADD NFKB1 TNFRSF1A RELB TRAF6 MYD88 TNF TRAF2 PMC4467640__F1 Cellular regulation mediated by extracellular matrix (ECM).Notes: The action of ECM components on the major signaling pathways of tyrosine kinase receptors, their links, and the outcome on tumor cell and chemotherapeutic response MAPKAPK2 BAD TSC1 HEL-S-28 MYC MDM2 CCND1 PTEN EIF4E HIF1A MTOR RHEB PMC7145977__F4 Hypothetical model showing the possible role of Sirtuins and circadian system in the pathogenesis of diabetic lung FOXO3A SIRT6 SIRT1 SIRT3 PMC8165182__F1 An Overview of Lung Cancer in Women and the Impact of Estrogen in Lung Carcinogenesis and Lung Cancer Treatment IGF1R CXCR4 EGFR SRC CXCL12 PMC9175535__F4 Reposition of the fungicide ciclopirox for cancer treatment TSC2 TSC1 EIF4E BNIP3 MTOR RHEB MLST8 PMC2684656__F1 Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress EIF2A TRAF2 TF PMC8582018__F2 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies GPX4 SLC7A11 ALOX12 PMC8582018__F1 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies HEL-S-102 GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 IREB2 SLC3A2 POR IPP DKFZp686F0183 PMC3632609__F1 Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain HEL-S-90n KYNU KMO AFMID IDO2 PMC10648005__F1 Main molecular consequences of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway activation PTEN MTOR FOXO1 PMC7936154__F1 Examples of potential miRNA-mediated regulation of metabolic pathways in chickens BAD IGF1 NR1C1 RXRA PMC3822721__F3 FHL1 isoform KyoT2 and Notch signaling NOTCH2 NOTCH4 PIAS1 NOTCH1 RING1 NOTCH3 PMC5919742__F7 Cell-type expression patterns of carbon metabolism-related genes in V HEL-S-26 MAS1 OGA PCK1 MBP FBP1 UXS1 GIP ACP2 PCK2 PGM5 PMC4598307__F7 Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism ADSL SENP1 ADA PMC9530844__F7 Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin EGFR GRB2 PMC6890664__F4 Altered cancer pathways in ASL, CCA and HCC PRKCI EGF HEL2 ALK FLNA TGFBR1 FGF8 TRRAP BRCC3 SSH2 RHO TTN FOXO1 ATM FGF10 HEL113 TRIM28 GNAS PMC7791126__F3 The TGFBeta-induced canonical SMAD and noncanonical signaling pathways SMAD2 MMP9 SMAD4 TRAF6 IL11 RHO MTOR BMF ID1 FOXP3 IFNG MMP2 GRB2 BCL2 MICA GATA3 TRAF4 PMC6304934__F7 FSIP1 regulates autophagy in breast cancer TSC2 ULK1 TSC1 APC FSIP1 MTOR PMC4315163__F4 G protein-coupled receptor pathway is involved in transmembrane signaling and diverse physiological functions including hormone signaling, regulation of cell contraction, cell migration, growth and differentiation FYN GRB2 ADRBK1 PMC7660609__F2 Role of HO-1 in I/R injury and cardioprotection HEL-S-62p PMC8853744__F2 Senescence in chronic wounds and potential targeted therapies IL6 DDB1 PMC5721403__F1 Targeting to bile acid and lipid metabolism in NASH treatment CYP27A1 BAD MMP2 FGF19 COL1A1 BAX PMC7460084__F1 Schematic presentation of transforming growth factor-beta (TGFB) signaling pathways SMAD2 SMAD4 MTOR PMC8020338__F4 Ingenuity pathway analysis of the TREM1 signaling pathway in the DH82 cell line treated with B TREM1 IRAK1 PMC8020338__F3 Ingenuity pathway analysis of the Toll-like receptor (TLR) signaling pathway in the DH82 cell line treated with B TRAF6 MAP3K7IP1 JUN PMC11351392__F3 Targeting the Nrf2/HO-1 axis for the treatment of IBD NLRP3 GPX4 PMC1431703__F5 Comparison of results with the known response pathway MRPL28 MRPL9 MRPL10 FAR1 PLP2 ISY1 CDC42 MRPL16 CDC73 PMC5824365__F6 String pathway to show the node of PD effects MYB NR3A2 MAPK3 TPO HIF1A BCL2L11 MBD3 KLK3 CCND1 HDAC2 MAPK1 SP1 MDK JUN MAFG IL10 FOS CD34 HDAC1 tal-1 CREBBP EP300 CXCR4 RELA STAT4 KLF4 NR2C2 LMO2 PMC5357489__F3 Cross talk of the Wnt/Beta-catenin pathway with the epidermal growth factor receptor (EGFR) and fibroblast growth factor (FGF) pathways in hepatitis C virus (HCV)-related hepatocellular carcinoma EGFR GSK3B LRP5 CCND1 LRP6 NKD2 PMC8530779__F7 Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing TLR7 IRF7 TRAF3 IRF3 MYD88 TNF IL1B TLR3 MAVS PMC9222488__F1 Clinical and Mutation Spectrum of Autosomal Recessive Non-Syndromic Oculocutaneous Albinism (nsOCA) in Pakistan: A Review SLC45A2 DCT SLC24A5 OCA2 PMC3840450__F1 The main actors intervening in the canonical and noncanonical NFKB activation pathways RELA RELB CD40 PMC10892344__F6 Schematic diagram generated by IPA of the death receptor signaling pathway with which the DEPs with |FC| ≥ 1 BANF1 LMNA FADD ACIN1 PMC3612647__F1 A lithium-sensitive family of small-molecule phosphatases and the sulfate assimilation pathway PAPSS2 FBP1 HEL20 PMC3840450__F2 Mechanisms of NFKB activation in T-ALL leukemic cells BCL10 NFKB2 CYLD RELA HES1 PMC9693004__F3 Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis BHLHB2 HAMP LACTB CLCC1 IL6 RHO RB1 IFNG HEL-S-125m ARHGAP4 MMP2 MRPS23 TYK2 MCL1 CD36 PMC8838174__F5 In Vitro Anti-Cancer Activities and Mechanisms of Action of 9-Methoxycanthin-6-one from Eurycoma longifolia in Selected Cancer Cell Lines BAD ROCK1 TNF DIABLO HTRA2 GAS2 HEL-S-162eP APAF1 ANXA2 MCL1 CAD BIRC6 CYCS BAX PMC4013580__F6 A schematic model presenting the pathway of BMP4 to affect foam cell formation BMPR2 ABCG1 ABCA1 SMAD1 DKFZp781O1323 BMP4 PMC5454932__F2 Intracellular GH signaling SRC MTOR PMC1297590__F2 Ubiquitination of key signaling in anergic T cells PC FOS JUN NEDD4 ITCH PMC6389164__F3 The genes and their functional relationships within the RLR signaling pathway TBK1 IKBKE IKBKG IFNA1 DHX58 CCL5 CCL2 RIPK2 IFNA5 STAT1 ISG15 RIPK1 IFNA8 CASP8 IRF7 CXCL10 MAP3K7 DDX3X IRF3 TRIM25 IL12B HEL-S-125m NFKBIA RELA CD40 CD80 TNFAIP3 IFIH1 TRAF2 MAVS PMC5125391__F2 Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells HDAC3 BBC3 GSK3B HDAC2 HDAC1 BAX PMC2603135__F6 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data RAD1 BAD FANCD2 BLM HDAC1 BRCA1 MCM2 RRM1 ATM RRM2 MDM2 MSH2 PCNA PMC2603135__F5 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data KLK4 RRM2 KHSRP GTF3C5 UTS2 GAS7 MTDH HDAC1 DDIT4 ZNF175 PMC8276974__F2 Both calcium channel signaling and ITIM containing receptor signaling are involved in leukemia progression by binding to and activating the Ca2+/calmodulin dependent protein kinase family BOC STAT3 PMC3153165__F1 Roles of the NFKB-mediated inflammatory pathway in cellular transformation and in cancer cell survival, proliferation, invasion, angiogenesis, and metastasis COX2 VCAM1 CXCR4 MMP9 CCND1 TNF PMC9069786__F11 Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway NLRP3 IL1B SOX4 STAT3 PMC8591178__F1 Inborn errors of IL-6 family cytokine responses CLC LIF CNTFR IL11RA OSM LAT OSMR PMC7004353__F9 Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development LRAT IGF1 CYP1B1 HEL-S-53e ACSS2 RDH10 RDH11 PMC7235771__F1 NGF and TrkA binding, just as BDNF and TrkB, leads to dimerization and autophosphorylation of receptors at tyrosine residues NGF RHO BDNF PMC7069804__F2 Schematic of microRNA networks affected by HIV virus TNPO3 CDC42 PMC5688216__F1 Regulatory T cell development (Churlaud et al TH TEC CD80 FOXP3 PMC5650366__F8 Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model ELF2 ATG12 ATG3 ATF4 ATG10 WFS1 TRAF2 ATG14 BAX PMC2213224__F8 Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion GRB2 SRC RAC1 RAF1 HRAS CRK CRKL PMC4535695__F1 Classical pathway for T cell activation CD80 PMC3807853__F9 IL-33 markedly activates murine eosinophils by an NFKB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop ADORA2B CXCL10 IL33 CCL17 CLEC4E CXCL2 TFEC PMC8676434__F4 Evolution of regulated cell death pathways in animals and their evasion by pathogens RIPK1 TRADD FADD BAX PMC8761471__F14 Long non‐coding RNA MIR31HG as a prognostic predictor for malignant cancers: A meta‐ and bioinformatics analysis MYB BAD DAO DAP PTEN PAG1 RXRA MAX BCR APIP CYC1 SYK CAD GAL LAT RBL2 CD19 PMC10556577__F1 TGFB signaling pathways (Activin and Bone Morphogenetic Protein) SMAD2 SMOX PS1TP5BP1 PMC5348720__F1 Viral infections in type 1 diabetes mellitus — why the B cells? IRF7 IRF3 CTSH GLIS3 TNF USP18 IRF6 STAT1 BACH2 TYK2 JAK1 IRF4 IL1B PMC3834158__F3 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats APOB SCARB1 CPT1A ABCG1 LDLR ELOVL6 ABCA1 TG HMGCR FASN PMC6885838__F10 Effects of hydrostatin-SN10 on the JAK2/STAT3 signaling pathway BCL2 TYK2 STAT3 PMC3834158__F4 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats CS ELOVL6 CROT TG PPARG NR1C1 FASN PMC6981958__F1 Interaction of p53 with different E3 ligases TRIM71 MDM2 RFWD2 PMC10967197__F10 The role of the IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1 axis in GBC angiogenesis AGO2 NUMB PABPC1 NOTCH1 IGF2BP2 HES1 PMC10239798__F7 Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A STAT1 STAT2 IRF3 DCP1A PMC7285825__F11 Ingenuity pathway analysis of functional relationships among genes involved in the IFN signaling pathway STAT1 STAT2 IRF9 PIAS1 TYK2 JAK1 IRF-1 IFNG BAX PMC11820142__SF7_3. Graphical abstract ROCK2 ROCK1 IRAK1 TRAF6 ARHA IL1R1 IRAK4 MYD88 ACE2 PMC4382988__F4 Ingenuity pathway analysis (IPA) of differentially expressed proteins PML HAPLN1 CTSS RTKN ACTA2 HSPA2 PLVAP ORM1 ISG15 DCN MATN1 OAS3 BPIFA1 LAP3 NCKIPSD XDH KRT4 KRT1 BPIFB1 BST2 HEL-S-130P SERPINE2 TAGLN TAPBP HP ISG20 DPT PYCARD PSME2 PMC7584092__F10 Drug-compound-target-pathway network CASP3 F10 PTGS2 F7 ALOX5 PTGS1 PMC5798330__F2 Transcripts relating to the classical complement pathway are overabundant in subclinical and active TB HEL-S-62p FCGR1A C4B_2 MASP1 FCGBP IL6 C4A CR1 CD59 C1QB C9 C7 C6 SERPING1 MASP2 CR2 PMC5955724__F1 Working model for Eph receptor function in tumor promotion and tumor suppression ERBB2 EGFR ARHA PMC3752772__F2 NFKB activation pathways triggered by TNF family signaling RELA RELB TNF PMC5819904__F1 Core components of the Hippo pathway TEAD3 TEAD4 RHO LPA TEAD2 PMC5819904__F2 Regulation of the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 CCND1 PMC8873791__F6 Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway ADAMTS5 ADAM12 AVPR2 AURKA AURKB ITGA2 P2RY2 KCNN2 NEK2 TGM1 SLC5A2 EPHB2 TERT PMC5819904__F5 Regulation amongst the Wnt/Beta-catenin, LPA and TGFB/Smad signaling pathways and YAP/TAZ of the Hippo pathway EGF APC LATS1 RHO LPA PMC6986449__F2 Differentially methylated promoter regions of genes in PI3K-Akt and NFKB signaling pathways during acute malaria TSC2 BAD TSC1 MDM2 GRB2 CCND1 CDC37 PTEN EIF4E TOX MTOR RHEB PMC11853522__F3 Interaction between nutrient-sensing pathways and mitochondrial oxidative stress and chronic inflammation PINK1 CGAS SIRT7 IGF1R IGF1 SIRT6 INS LRRC17 MTOR SIRT1 SIRT3 PMC2847476__F3 Immunoregulatory Functions of mTOR Inhibition PIM2 CCR7 KLF2 PTEN FOXP3 PMC7378638__F5 Enterohepatic action of FXR and FATP5 FGF19 FGFR4 TG PMC4829974__F3 Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes PLCG1 MAPK8 ATF2 MYC RB1 CCND3 CDKN2A CCNE1 CHEK2 ITK LCP2 BCL10 MAP3K19 ATM F3 CCNB1 PTPN11 CCND1 CDK4 CDC2 PTPN6 ICOS ARID3A HOXA9 PRKCQ CTLA4 CDC25B CHEK1 ARID1A IKBKB PTPRC CARD11 CREBBP EP300 CDKN1A RPS6KA1 F5 CDK2 LCK ZAP70 GRB2 SOS1 ATR LAT HIC1 CDC42 PDCD1 PMC10374588__F2 Pathways controlling pyroptosis, apoptosis, ferroptosis, and cuproptosis LIAS FDX1 LPCAT3 TRADD FACL4 NLRP1 FES TFRC SLC31A1 GSDMD NLRP3 RIPK1 AIFM2 TLR4 ATP7B NCOA1 SLC40A1 TRAF2 AIM2 FADD DLAT BAX PMC7487264__F3 Activation of the PI3-kinase/Akt pathway by VacA PI3 APC CCND1 PMC4736209__F2 Schematic illustration of an inflammatory IDO activation by LPS and inflammatory cytokines and possible regulatory mechanisms on transcriptional, posttranscriptional, and posttranslational level SOCS3 BIN1 LAT PMC4736209__F1 Main pathways of TRP degradation including enzymes and their potential stimuli (modified after [, , , ]) KYNU KMO AANAT PMC6039108__F3 Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned PALB2 POLE BRCA2 RAD51 PARP1 BRCA1 PMC10374588__F4 Graphical depiction of the mechanism of classical pyroptosis pathway and non-classical pyroptosis pathway TLR4 MYD88 IL1B GSDMD PMC4201220__F2 Wnt/Beta-catenin signaling pathways and a strategy for the phenotype-based drug identification using C APC GSK3B POP1 SYS1 PMC9267148__F12 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis SMAD2 TGFBR1 SMAD4 CIAPIN1 PMC9267148__F11 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis SKIL ZFYVE9 TGFBR1 SKI TGFB1 PMC4008712__F1 Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood HK3 GRB2 MAP2K2 MAPK1 ARAF SOCS1 CBL PMC4736209__F3 Possible interaction between inflammatory IDO activation and AhR-mediated effects AHR SRC STAT3 PMC11536562__F2 Alpha-KG homeostasis and m6A regulation HEL-S-26 MYC CEBPA PFKP HEL-S-281 PMC5348361__F9 Components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model MAF BAX PMC7205831__F8 Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide‐induced acute lung injury TLR4 IL1B PMC9321602__F1 Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy FEN1 PALB2 BLM RAD50 RAD52 RAD51 PARP1 LIG1 MRE11A DNA2 BRCA1 PAXX PMC3814314__F5 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish NLK NODAL NKX2-5 PITX2 APC SRC SFRP1 GSC TLK2 DKK1 SKI PMC11536562__F4 Promotion of ILC3 cell proliferation in m6A-dependent manner NOTCH2 ALKBH5 PMC11536562__F3 m6A modifications in fetal hematopoiesis and HSC maintenance YTHDF2 BAD RUNX1 MAPK3 MYC BMI1 FZD1 SOX17 YTHDC1 GATA2 RNASEL STAT1 METTL3 NOTCH1 BCL2 MCL1 BAX PMC5389546__F3 let-7c is predicted to target the RAS signaling pathway and miR-98 ME1 NF1 BAD NFIB RHO RAF1 NOM1 LAT PMC3814314__F6 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish SPARC HHIP INVS NODAL PSEN2 PITX2 DKK2 TNC FOXD3 LEF1 SMARCA4 ATOH7 NPY AXIN1 TFAP2C DVL2 ZIC3 PMC8740130__F6 Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network FACL4 SI LPL PMC3980586__F1 Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer SIRT7 RPS14 RPS18 MYC RPS7 MTOR PMC8382834__F1 Impact of severe hypoglycemia on the heat shock and related protein response HEL-S-102 UBE2G2 HEL-S-94n PPP3CA STUB1 MAPKAPK5 DNAJB1 HEL-S-72p IAPP CLU PMC9351103__F8 Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathway CXCL8 IL8RB CDH2 MTOR IL1B PMC4033570__F5 Simplified network diagram showing the involvement of JNK and p38 in the system TRAF6 JAK1 OSM STAT3 PMC12205809__F6 Pro-inflammatory C-X-C motif chemokines (CXCs) play a crucial role in the progression and development of breast cancer in aged patients, postmenopausal women, animal models, and senescent cells CXCL1 AGTR1 ACACA CXCL10 CXCL8 CXCR5 ARHA FREM1 SOX4 CXCL13 CXCR3 CXCR4 CXCL9 CXCL12 CXCL11 PMC12205809__F5 Stroma phenotype of catabolic tumor SHH HIF1A STAT3 PMC6089851__F2 Major downstream targets of ERK1/2 in the MAPK pathway FYN FOS MYC GRB2 SRC JUN PMC4926232__F7 FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct RUNX1 BMP10 SMAD4 BMP4 FGF7 PMC6089851__F1 Major RAS family numbers ARHH REM2 RHOV RAP2C REM1 ARL13B RAP2B DIRAS2 RHOBTB3 RASL11B DIRAS3 ERAS RHEB RHOBTB2 ARHG RAC3 RAP1A ARL2 NKIRAS1 NKIRAS2 ARL11 RND1 RASL10B CDC42 RASD1 GEM RERG RHO RIT2 RAP2A RHOU ARFRP1 DIRAS1 RASL11A ARL5C ARF4 ARL14 ARL4D ARL6 ARL9 ARL3 RASL12 ARF3 RASL10A ARL15 RHEBL1 RHOBTB1 RASD2 ARL16 RND2 RRAS RAC1 RRAS2 ARF1 TRIM23 ARL1 ARF5 HEL-S-42 RHOF ARF6 RAN PMC9452894__F3 Chemistry and efficacy benefits of polysaccharides from Atractylodes macrocephala Koidz GSK3B BAX PMC2455793__F1 Interaction between two known Egr1 target genes, PTEN and fibronectin achieves a delicate balance between attachment and apoptosis of detached cells (anoikis) EGR1 BAD PTEN PMC6089851__F3 Activation and feedback regulation of the MAPK pathway DUSP5 FYN GRB2 CCND1 SRC BCL2 HBEGF MCL1 TGFA PMC9138619__F3A Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids EPOR CCR2 EPO SOCS3 TNFRSF12A FLT4 CXCL3 GSDMD MMP3 CCR7 TNFSF12 CXCL11 OSTN IRF7 PLG FOS IRF9 CXCL10 TNF EDAR VEGFC NFKB2 CXCR4 CCL20 MAP3K14 CXCL12 CORT TNLG2A CSF3 VEGFD RELB BTK PDGFD IL18 BASH CCL27 JUN SELE CCL11 BMP2 PTGS2 CXCL2 IL6 TNLG2B TNLG7C CXCR3 LTA LYN JAK1 CSF1 OSM PMC8888757__F8 Proposed simplified model of ADAP1-mediated T cell signaling stimulation leading to latent HIV-1 reactivation FOS ALB JUN PMC9027133__F5 Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives GPC4 GPR158 CAV2 BDNF PMC9118275__F3 MicroRNA-96: A therapeutic and diagnostic tumor marker SFRP4 APC NPTX2 GSK3B PMC11898300__F5 Diagram of tumor cell biomechanical perception, conduction, and effect mechanism PIEZO1 HEL-S-11 RHO MTOR PMC8243062__F3 NRF2 signalling pathway and antioxidant therapeutic approaches MAF TBK1 KEAP1 GSK3B BRCA1 BACH1 PMC8806153__F3 Metabolism of memory CD8+ T cell differentiation TSC2 TSC1 RHEB OPA1 AQP9 PMC9340488__F4 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions TRADD IRF7 IRF9 CXCL10 RELB IRAK4 IL6 CCL2 MYD88 TLR3 ADAM17 STAT1 TLR8 TLR7 TLR4 CXCL9 TYK2 ACE2 IL1B TMPRSS2 STAT3 PMC9340488__F2 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 ACE2 TMPRSS2 PMC3328890__F1 ROS-dependent and -independent apoptosis induced by particulate pollutants BAD AHR MCL1 BAX PMC5891223__F5 Epidermal Growth Factor Receptor Signaling to the MAPK Pathway Bypasses RAS in Pancreatic Cancer Cells EGF PAK1 EGFR CDC42 PMC8517597__F2 Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment CTSK CXCL10 IMPACT TNF PMC2949087__F5 Mitochondria and neuroplasticity PINK1 LRRK2 HTT APP BDNF TF PMC6876280__F1 An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer EZH2 SUZ12 EED PMC1890373__F2 Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands ATR CD36 HEL-S-5 HEL-S-162eP PMC7912608__F5 Diversity of NO functioning in cancer COX2 PTN CXCR4 HIF1A PMC8429462__F8 Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine TBK1 DDC IRF3 PMC5448443__F1 Amyloidogenic and non-amyloidogenic processing of the APP BACE1 EGF NGF APP IL8RB GPR3 PMC4450051__F4 Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex CD14 CTSK TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 CPO RAE1 LBP CD40 CD80 IL1B FADD TIRAP ELL PMC8113849__F1 Estrogen and estrogen receptor-mediated pathways in thyroid cancer PI3 TRIM16 WNT1 EGFR IQGAP1 NOX4 PTEN RAF1 MTOR PMC8621031__F2 Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models SMAD2 SIRT1 PMC4904902__F1 AMBRA1, a novel mitophagy receptor PINK1 AMBRA1 BCL2 PMC4560339__F1 Multimodality targeting of MM in the context of the BM microenvironment PDC HGF IGF1 MYC VEGFA SLAMF7 CXCL12 BRD4 PMC5149521__F3 PKB associated signal transduction pathways BAD GSK3B MDM2 EIF4E CAD MTOR PMC9578220__F6 Novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients CD47 HLA-G TNFRSF4 TNFRSF18 CD40LG HLA-DMB BTNL9 PMC6103702__F5 Representative cell cycle pathway between PCOS arrested and non-arrested 2-cell embryos CDK2 SMAD2 SMAD4 ORC1L ORC3 RAD21 CDK7 CDC45 PCNA ORC2 SKP2 PMC7662147__F2 Life cycle and cleavage of SARS-CoV-2 and ENaC in airway cells CAP1 FURIN ACE2 TMPRSS2 PMC5751286__F2 Schematic view of (A) the NFKB signaling pathway and (B) the JAK-STAT signaling pathway that contribute to the pathogenesis of psoriasis and its novel targeting molecules IL24 IL6 MAVS PMC4230721__F3 Compounds used as anti-fibrotic therapies in other organs and their mode of action HGF MTOR PMC7576264__F9 Rab27A promotes ROS production and apoptosis via suppressing miR‐124‐3p and increasing STAT3/RelA pathway in inflammatory colonic cells RAB27A RELA STAT3 PMC2605487__F2 Signalling pathways involved in the induction of astrocyte specification/differentiation CNTF LIF GFAP SMAD4 SMAD1 STAT3 PMC4578651__F4 Chymomyza costata exposed to Long Day (LD), Short Day (SD) and Transfer (T) from LD to SD photoperiodic conditions AGO2 DPY30 E2F2 C13orf34 MYT1 PMC7962892__F1 TNFAlpha-induced signaling pathway of cell survival, apoptosis and necroptosis TRADD TRAF5 TRAF2 FADD MLKL PMC8530315__F7 VitD3 effects in D3-MDMs during DENV-2 infection STAT1 OAS1 TLR7 NR1i1 TLR9 STAT2 IRF9 TLR3 CYP27B1 PMC6488436__F1 Sphingolipid metabolism CERS3 LASS1 DES CERS5 CERK SMS CERS2 CERS6 PMC5816341__F1 Schematic diagram of the three pathways of the complement system, highlighting the upregulator (properdin) and downregulator (factor H) of the alternative pathway HEL-S-62p CS TSR3 TSR2 TSR1 C6 C1S C4A PMC8050350__F5 Metabolic Signature of Autoreactive T cells in Rheumatoid Arthritis SLC5A12 SUCLG2 PMC7156472__F6 Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer MVD SHH PMC3377280__F7 Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition PLK1 WEE1 RAD51 CDC2 PMC9614365__F1 Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases LEF1 IFNG FOXP3 GLS PMC7411130__F3 Regulators of the complement pathway HEL-S-62p CD59 C4B_2 VTN C7 C6 CR1 PMC6938958__F8 Identification of Regulatory Modules That Stratify Lupus Disease Mechanism through Integrating Multi-Omics Data E2F4 STAT2 ELF1 BLM IRF9 CDKN1B PSMA4 PSMB2 MYC E2F5 IFIT5 STAT1 ISG15 MNT MAX TYK2 RAD51 PSMB9 PSMB8 RAD51B TF SOCS1 PMC2136409__F7 Genetic and epigenetic mechanisms of gene regulation during lens development MAF FGF2 FGF8 GRB2 PMC3253704__F1 Prominent signaling pathways involved with PDAC tumoral compartment and stromal compartment crosstalk SHH SMO PMC7913053__F1 Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis NOX4 DKC1 TPP1 TERT PMC3232381__F1 Tumour necrosis factor receptor 1 (TNFR1) and its signalling pathways TRADD TRAF2 FADD PMC4742793__F9 Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin WNT7A LRP5 LRP6 PMC5624958__F7 Schematic diagram of the proposed mechanism by which OCA may modulate the IL-6/Jak-2/STAT3 signalling pathway in HCC cells SOCS3 IL1B STAT3 PMC6939459__F10 Conceptual models of mitochondrial metabolite transport and the consequence of metabolic perturbations on Th1 cell activation TH CIT MAL PMC8383068__F1 Proteomics Mapping of the ISGylation Landscape in Innate Immunity ISG15 IRF9 SRC IFNGR2 IFNAR2 UBA7 JAK1 IFNAR1 IFNGR1 UBE2L6 USP18 PMC6933925__F2 Possible rational combination treatments for HH/GLI-associated cancers simultaneously targeting HH/GLI and HH-regulated immunosuppressive and tumor-promoting signals IL10 CCR2 SHH IL11 IL6 CCL23 IL1B IFNG STAT3 PMC3562341__F4 Accumulation of Splice Variants and Transcripts in Response to PI3K Inhibition in T Cells ITK FYN LCK ZAP70 GRB2 TEC SHB LAT PMC5908737__F3 MUC1-C ACTIVATES POLYCOMB REPRESSIVE COMPLEXES AND DOWNREGULATES TUMOR SUPPRESSOR GENES IN HUMAN CANCER CELLS MYC RING1 BMI1 TG PMC6940409__F2 Photic- and non-photic-responsive MAPK signaling pathways in the brain PMC5416959__F10 RFC-PCNA complex inhibiting cell proliferation RFC1 RFC2 PCNA RFC3 RFC4 RXRA PMC9539821__F2 Epigenetic factors in breast cancer therapy DKK3 APC GSK3B PMC3142564__F1 Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer BAD GSK3B MDM2 PTEN RAC1 LPA MTOR PMC6625911__F1 CaMKK2 and advanced glycation endproducts (AGEs) within the bone microenvironment ALPL TLR4 CTSK RUNX2 BMP2 NFATC1 ACP5 CEBPA CEBPB SOX9 CAMKK2 PMC2657945__F1 The TSC-mTOR signaling TSC2 TSC1 PTEN SGK1 RHEB PMC7983599__F1 Effect of Thyroid Hormones on Adipose Tissue Flexibility CPT1A TRH TRO PMC2657945__F2 Regulation of the mTORC1 pathway by two distinct small GTPases TSC2 TSC1 RHEB PMC6497036__F10 Proposed mode of action for RHOA to maintain TE characteristics in the expanding blastocyst AMOT NF2 ARHA PMC9138619__F2A Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids EPOR CORT TH CCR2 CCR3 NGF FLT4 CAST MAPK14 CCL2 NOD2 BTK BCL10 BASH TNFSF14 CSF2 IRF-1 SELE CXCL11 OSTN PLG BMP2 LIF CXCL10 LTB IL8RB CXCL2 TNLG2B TNLG7C CXCR3 VEGFC LTA RELA LYN CCL20 REL OSM TRAF2 LTBR PMC8273970__F10 EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway AGO2 ASPH ZEB2 VEGFA ONECUT2 EIF4A3 PMC5859524__F1 Regulation of the cell cycle ATM ATR BAX PMC2424193__F6 Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells IL10 IKBKE IKBKG TRAF6 HSPD1 IL6 TNF CFTR IFNG HEL-S-269 NFKB1 IL4 TRAF2 HSPA4 STAT3 PMC3539910__F2 Carcinogenesis of colorectal cancer cells and role of different miRNAs in cancer pathways CASP3 BAD SMAD2 APC EGFR CASP9 SMAD4 CCND1 PTEN DCC BAX PMC8678087__F1 Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration MYF5 PAX7 PAX3 MYOG PMC4270317__F5 Cell cycle pathway MALL CDK2 F5 FAP CDK7 PMC11994677__F1 Crosstalk between KTRM and renal cellular networks S100A8 S100A9 MYD88 TNF CSF2 STAT3 PMC5345622__F1 Occurrence and regulatory mechanisms of ferroptosis in a cell GPX4 CS IREB2 ACSF2 IPP TF PMC7512067__F6 Summary diagram outlines the working mechanisms of oridonin in FaDu cells WNT3 CDH2 PMC4780413__F6 Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation SRP54 RBBP4 NEUROG1 MAPK3 GSK3B HMOX1 PDPK1 IFNG CCNE1 TNFSF6 ZNF423 MAPK1 RAP1GAP NOS2 ITGB3 WASF1 PSEN2 ATF3 PSAP TNF CYBB CDKN1C IGF1 BCL2 TGFB1 LAT CP HGF ACHE MATK SYCP3 ATM IL2 PDCL TFF3 IL4 IL1B GPHN DLGAP1 PTGS2 STXBP5 NR3C2 PARP1 AIRE IL6 DDIT3 IKBKB NEK3 EP300 LYN MCL1 SELP FADD TSNAX PMC9027478__F1 Notch signaling network in muscle stem cells during development, homeostasis, and disease RBPJ DLL4 PAX7 PMC2637474__F7 Hypothetical pathway involved in general cerebellum-mediated motor learning DCN CS GC PMC4412130__F1 Eukaryotic mechanisms that manage replication– transcription conflicts MRC1 TREX2 ATR PIF1 PMC12205809__F4 Interleukin (IL)-10/11/tumor necrosis factor (TNF) and transforming growth factor (TGF) pro-inflammatory cytokines play a role in breast cancer in postmenopausal women and senescence cells, as shown in the illustration SDC1 IL11RA SP1 TNF STAT3 PMC12205809__F3 Pro-inflammatory cytokines (interleukins/ILs) play a role in aged/postmenopausal breast cancer women or animal model/senescence cells, as depicted in the illustration STAT1 CGAS KDM2A STAT3 PMC7967218__F2 Histone acetylation regulates genes involved in cancer progression EPCAM SMAD2 TGFBR2 RAB25 SMO BMI1 ST14 HDAC1 ESRP1 FOXF1 PMC4323104__F7 Clinical Proteomics Identifies Urinary CD14 as a Potential Biomarker for Diagnosis of Stable Coronary Artery Disease CD14 GLB1 GLIPR2 LGALS8 VASN HAS3 FUCA1 CD59 CMTM8 F2 PKN2 SERPINA1 APOH PMC12065104__F5 Molecular and signaling changes between a normal melanocyte and a melanocytic melanocyte STAT1 NF1 MDM2 CDK4 PTEN JAK1 IRF-1 CDK6 IFNG PMC5350610__F3 The consequences of perturbation of CUL4CRBN E3 ligase function DDB1 CRBN PMC3618441__F1 Membrane-initiated Actions of Estradiol that Regulate Reproduction, Energy Balance and Body Temperature PLCG1 STAT3 PMC7160552__F3 Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases NODAL PRSS8 GC KLF2 MMP16 EZH2 HOXA2 PMC7160552__F2 Schematic diagram that introduces in detail the molecular mechanisms, clinical values and cell phenotypes affected by HOXA11-AS in different tumor types, including (A) NSCLC, (B) HCC, (C) glioma, (D) CC, and (E) BC PDE4D DUSP5 CDK2 DOCK8 CDK4 LATS1 EZH2 HOXA2 PADI2 STAT3 PMC8509647__F3 Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment HEL-S-62p CFHR3 C4B_2 CFHR4 CFHR5 C4A CR1 CD59 CFHR2 C9 FH C7 C6 CFHR1 PMC7853511__F8 Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities APC NTS TRPV1 PMC5299705__F7 The regulatory network of HOTAIRM1 involved in the autophagy pathway and the degradation of PML-RARA ULK1 DRAM2 PMC9576592__F7 Schematic model depicting the functions of SNHG5 during the proliferation and cancer stem cell-like properties of HCC SOX2 WNT3A WNT1 CD44 CCND1 WNT10A TCF4 PMC2257939__F2 Bimodal genes highlighted in KEGG ECM-receptor interaction diagram CD47 CD44 VWF CHAD CD36 PMC7843937__F8 An overview of pathways involved in mediating Cor and DDP-induced cellular effects CASP3 CCND1 MTOR PMC7768751__F1 Role of Diet and Phospholipase D enzyme in the complex network of choline pathways and Choline-Mediated 1C metabolism PC PEMT PMC7456829__F4 Pathways of anti-TNF monoclonal antibodies action in Crohn's disease (CD) FCGR3A TNFRSF1B ADAM17 PMC7037830__F3 Binding mechanism of LPS for TLR4 activation CD14 TLR4 LBP PMC4536973__F1 Physiopathological actions of periostin activation PI3 WNT3 BMP2 SMAD2 EGFR PMC9312508__F10 Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans TBK1 TLR7 TANK STAT2 TRAF3 TRAF6 TYK2 MYD88 JAK1 TLR3 MAVS PMC9329783__F1 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms PLCB2 CALHM1 TRPM5 PMC4423042__F6 Cartoon representing LPA-activated signaling cascades that regulate OHC motility, as suggested by our results and previous studies (in black font), as well as potential mediators and interactions that require confirmation (gray font) LIMK1 ARHA LPA PMC7691485__F3 Basic components and rough characteristics of each indicated signaling pathway in relation to primary cilia PDGFRA SUFU SMAD2 EGFR TGFBR2 SMAD4 SMO ADRBK1 GLA PMC5789373__F2 Cross-talk of mTOR with other signaling pathways TSC2 TSC1 MDM2 PTEN SKI RHEB PMC7770202__F1 Signaling pathways of interest in the peripheral and central nociceptive pathway CALCA NGF ATF3 TACR1 TRPV1 COX2 NPY NFKB1 RELA TRPA1 BDNF RAMP1 IL1B PMC9329783__F3 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms PLCB2 CALHM1 TRPM5 STAT3 PMC7770202__F8 Response to aging in the mouse somatosensory nervous system CALCA NPY NFKB1 RELA ATF3 TRPA1 BDNF RAMP1 PMC6613841__F8 Proposed mechanisms underlying the regulation of innate immune response by influenza virus H5N1/HM M2 protein IRF7 IRF3 DKFZp686F0183 MAVS PMC2984239__F5 Merged network pathway analysis of proteins involved in cellular assembly and organization, cellular compromise, and protein folding that were identified in cytoplasmic fraction TRMT112 HNF4A TRMT1 WNT10A PHB2 PMC6192633__F8 GPR108 works as a dual functional regulator to balance the TLR-triggered immune response TLR4 TRAF6 MYD88 GPR108 TIRAP PMC4350884__F8 EtOH and INK128 impact on the mTOR pathway and cellular response RICTOR EIF4E MTOR PMC11215396__F1 CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis EPOR HEL-S-99n MPL PMC6722206__F1 miRNAs orchestrate T cell metabolic reprogramming CPT1A MTOR PMC6166692__F2 Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes STAT1 SUMO4 MYD88 JAK1 IFNG PMC6365085__F9 MicroRNA-223 attenuates LPS-induced inflammation in acute lung injury model via the NLRP3 inflammasome NLRP3 TLR4 IL1B RHOB PMC9589179__F7 Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid Leukemia APC CD96 BTLA CD80 TIGIT LAG3 CD226 FGL1 CEACAM1 PMC2921074__F1 Modulating immune function and controlling inflammation HMGB1 TNF STAT3 PMC8257046__F8 SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects ROCK1 DVL2 ARHA RAC1 PMC4227186__F6 TCDD induced HIF-1A molecular signaling PIGF AHR VEGFA TFAM UCP2 PMC5421298__F6 Gene expression changes in the TGFB signaling pathway BAMBI E2F4 SMAD2 TGFBR1 MYC SMAD4 TFDP1 FST NOG DCN BMPR2 THBS1 SP1 RBL1 ROCK2 INHBC ACVR1 ZFYVE9 BMP2 SKP1 ARHA TNF SMURF1 RPS6KB1 CREBBP CDKN2B BMPR1A ACVR1B SMAD1 PMC5421298__F5 Gene expression changes in the Wnt/Beta-catenin signaling pathway BAMBI PLCB3 INVS BTRC RUVBL1 NOTUM TP63 GSK3B MYC SMAD4 CAMK2G PORCN ARHA SOX17 NFATC3 CCND2 PRKCA CREBBP AXIN1 NR1C2 DVL2 JUN FZD10 PMC7037830__F4 Illustration of TLR4 signaling pathway TBK1 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TIRAP PMC4859668__F3 DDX3 is involved in Wnt/Beta-catenin pathway MMP7 APC LRP5 CCND1 LRP6 BCL9 PMC10472599__F8 Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML SET CXCR4 MSC CD34 CCND1 CXCL12 MTOR CDK6 CD69 PMC2681728__F8 Proposed model of the role of p47 in E FYN PCGF5 PMC8469604__F6 Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing KEAP1 FTL HEL-S-44 HMOX1 NQO1 UCP2 PMC2933544__F3 Proposed model of epidermal growth factor receptor (EGFR) aberrant activation and trafficking in the setting of cigarette smoke (CS) EGF CS EGFR GRB2 PMC4464707__F4 Integrated regulatory graph was constructed as a prediction for the regulatory pathway of IMP metabolism CEBPE GDE1 HSPA2 ETV6 PTEN CDX2 MNDA GJA1 CD2 GABPA HEL-S-70p THBS1 BPI HSPA4 PMC4078307__F1 Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival TH PNMT DDC DBH PMC7304430__F12 Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research TRADD TRAF2 IRS1 PMC3726197__F1 Signaling axis exploited in the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutant mouse model of prostate tumorigenesis BAD PTEN MTOR PMC5869686__F5 Representation of the TCA cycle and glyoxylate shunt pathway SDHC SDHD SDHA SDHB PMC6500618__F7 A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis CASP3 IL23A RELA MAPK14 MCL1 TNF JUN PMC9653866__F2 BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment BTN3A3 APC IL4 IFNG STAT3 PMC4160455__F1 Multiple mechanisms lead to the development of PPCM in mice ERBB4 NRAS PRL STAT3 PMC11121000__F1 Insights into Salinity Tolerance in Wheat CLC PMC5349926__F2 Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling PIK3R1 TBK1 PLK1 PTEN BCL2L11 BMF DNMT3B CDK6 MAPK12 PRC1 CRP MDM2 SP1 FRAT2 GPR37 TPRN FOXO3A FOS DIRAS3 CCKBR BBC3 KLF4 BCL2 MCL1 DUSP2 LAMC1 PMC9041553__F2 Ex Vivo Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside HEL-S-62p C9 CS PLG VTN FH C7 C6 CAD CR1 CP PMC8393646__F9 Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2 HEL-S-51e PMC3110099__F14 Schematic diagram to show that knockdown of Akt1 leads to upregulation of Akt2 in response to oxidative stress and its regulation of oxidative-stress-induced apoptosis through three pathways GSK3B MDM2 PMC4324359__F2 Differentially expressed gene enrichment of the top scored pathway maps ATF4 TRAF2 XBP1 JUN DNAJC3 BAX PMC5601305__F1 Mechanisms used by Toxoplasma gondii, type I strain, to modulate mainly immune system at its favor IDO1 EGF NOS2 TGFB1 IFNG PMC7890269__F7 Proposed model TFEB NR3A2 PMC7457135__F1 Protective and detrimental roles of mitochondrial reactive oxygen species (mtROS) during infection NLRP3 TLR4 KEAP1 TRAF6 TIPARP ECSIT TLR1 TNF MTOR MAVS GABARAP SIRT3 PMC8455891__F1 Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis HACE1 STAMBP USP18 RNF168 RNF170 FBXO11 HEL-S-305 HERC1 CUL7 USP9X KCTD13 FBXO31 MAGEL2 USP22 UFC1 NHLRC1 UBE3A FBXO28 USP27X OTUD7A ATXN3 UBR7 LRSAM1 TRIM2 HECW2 IRF2BPL HUWE1 FBXW11 RHOBTB2 RNF125 CUL4B MID1 PSMD12 PARK2 TRIP12 STUB1 TRIM37 CRBN ITCH PMC10531449__F3 Transcriptomics of Canine Inflammatory Mammary Cancer Treated with Empty Cowpea Mosaic Virus Implicates Neutrophils in Anti-Tumor Immunity TH MAFK LCN2 COIL FADD ELL TAB3 PMC3243339__F8 Depiction of how D1 and c-Myc proteins regulate CDDP-induced cell death, with arrow indicating induction and hyphen (-|) indicating inhibition BIRC5 NFKB1 RELA RELB PMC3567827__F1 Hh signal transduction in Drosophila and mammalian systems GPC4 KIF7 GPC3 SUFU SMO GAS1 SPOP GPC6 ADRBK1 PMC11943624__F3 Key metabolic pathway components and targets for nanomedicine-based targeting (rectangles represent components, rounded rectangles represent enzymes, and dashed lines and multiple arrows indicate omitted multistep reactions) DHFR NPC1L1 IMPDH1 IMPDH2 HEL-S-70p CAD DHODH HEL-S-133P HMGCR CD36 PMC7773645__F1 NLRP3 inflammasome pathway associated with potential blockade sites of various pharmacological inhibitors to treat fibrosis NLRP3 IL16 TLR4 MNT NOX4 TXNIP MTOR IRS1 CD36 PMC8392679__F3 Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression WNT3A NECAB3 CD163 MDM2 PTEN ARG1 TCF4 GATA3 PMC2118167__F7 Proposed model for the intersection of innate and adaptive immunity during polysaccharide-induced abscess formation in the peritoneal cavity STAT4 PMC7244458__F2 Mast cells (MCs) respond to a wide range of pathologic and environmental stimuli owing to the expression of toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs) CCR5 CXCR1 CCR3 CCR4 IL8RB CXCR6 TLR3 CXCR3 TLR7 FYN GAB2 LYN CCR7 GRB2 SYK PMC10991391__F3 TGFB influences cellular metabolism through canonical and non-canonical pathways SMAD2 SMAD4 HEL-S-51e MTOR PPARG PHGDH PMC10991391__F5 Cellular metabolism and myofibroblast contraction cascades SMAD2 SMAD4 RHO HEL-S-51e MTOR PHGDH PMC10991391__F2 Integrin receptors influence cellular metabolism through ECM sensing LPIN1 TRIM21 RHO MTOR PMC8801022__F2 Mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease PINK1 FUNDC1 BCL2 PMC7794837__F1 Altered Ca2+signaling in T cells during aging—impact of ion channel expression and function ZAP70 IL2 TRPM2 ORAI1 TRPM7 FOXP3 PMC3160099__F7 Pathways that control the onset of adulthood and the terminal differentiation of specific cell lineages are conserved from C LIN28B c-fgr SF1 LHB PMC5496266__F6 The roles of microRNA families in hepatic fibrosis HGF TGFBR1 TGFBR2 CCNE1 PMC34619__F2 Signaling to eukaryotic translation initiation and elongation factors EEF2K EEF2 MTOR EIF4B PMC10141515__F6 Differentially expressed proteins of the serine metabolic pathway in ovarian cancer PSAT1 PSPH HEL-S-51e PHGDH PMC10572723__F3 Interacting compounds and PTMs of PPARG that regulate its function in the endothelium EGFR PIAS1 FOXO1 PMC12017852__F5 Signaling pathways of RGS12 in tumor MYCBP2 ARHA MNX1 PTEN RGS12 MTOR PMC12017852__F4 Relevant signaling pathways of RGS12 in arthritis RGS12 TNF PMC5496266__F2 The roles of microRNA families in hepatic fibrosis PDGFC IGF1 AKT3 PMC9030597__F1 Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment FOS NFKB1 GPX1 NOX4 HEL-S-44 CYP1A1 SP1 PMC8270011__F2 Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins HEL-S-62p VCAM1 C6 PMC5504108__F2 Therapeutic targets that regulate YAP/Hippo activity in mesothelioma ROCK2 ROCK1 NF2 LATS1 RHO CDC2 CDK9 PMC7938710__F3 Network analysis using the Ingenuity®Pathway Analysis (IPA®) software program ALDOB ADGRF5 GPR55 RSPH6A GPR143 GPR137 SSTR4 DRD2 TSG101 FGD2 GALR3 DTYMK CASP9 UNK PMC8438004__F1 St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity GFAP TG PMC3115327__F3 Scheme of the signal transduction pathway in response to DNA damage RAD1 ATM ATRIP GADD45A PMC4717889__F1 TLRs play critical roles in gastrointestinal inflammatory disorders at the mucosa TBK1 CD14 TLR9 EGFR TRAF6 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 SIGIRR RORA JUN TIRAP PMC4598795__F6 Cd-elevated genes associated with mitochondrial oxidative phosphorylation pathway that occurs in electron transport system ZNF183 NDUFS1 NDUFB3 SDHAF2 NDUFB5 PMC5982776__F4 The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival USP4 GDA GFAP PSAP PTEN MTOR RFWD2 TSC2 USP12 SIAH1 IGF1 PERP ATM APAF1 USP46 RAX GNAL GAL PIGA ATR BAX PMC5245710__F6 Human SRMAtlas: A resource of targeted assays to quantify the complete human proteome NUSAP1 KIF23 SHMT1 MCM7 IPO5 PNN UHRF1 TOP2A PRIM1 RFC3 SPAG5 MCM5 LMNB2 HNRPA3 MCM2 RRM1 RRM2 NCAPG SRM PRKDC HMGN2 MKI67 PCNA PMC8431517__F4 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout CDA NR3A2 EBP TYMP DNMT3B SPHK2 TRPV1 CHEK2 PRKCA RARB TLR4 NR1i1 SHBG CYP17A1 PLG HSD11B2 NR1C1 HEL-S-162eP ADA NR1C2 PARP2 RORA DHODH PLA2G2A PPARG PNP PMC3930975__F1 The unfolded protein response pathway ATF4 XBP1 PMC7793096__F3 Carbon monoxide-induced phenotypic switch of macrophages IL10 CD80 PMC8772992__F3 Preventive Effects of Beta-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD) AKR1B10 DGAT2 CRABP2 HEL-S-53e RDH5 ADH1A RXRB RARB DGAT1 CYP26A1 LRAT CYP26B1 ALDH1A3 CRABP1 RBP4 DHRS4 DHRS3 RDH10 ALDH1A2 ADH1C HEL-S-117 RDH11 PMC4934035__F5 The pathway of LysoPC16:0 PC LPA PMC5617461__F9 Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma ITGA1 GBP1 KRT16 FOS KRT13 ITGB1 JUN PMC3666557__F2 Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration ATF4 EIF2A PMC8269281__F1 Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis NGF GRPR IL33 TSLP ITCH PMC11039397__GA1 StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NFKB/p-ERK MAPK-NFATc1 signaling pathway AIP CTSK AHR NFATC1 DCSTAMP ACP5 ATP6V0D2 PMC6001649__F2 Salivary Exosomes: Emerging Roles in Systemic Disease HEL-S-276 PTEN PMC7564398__F1 A high-fat diet (HFD) and chronic cannabidiol (CBD) administration on the sphingolipid metabolic pathway in rat myocytes SPTLC1 UGCG DES SPHK2 PMC5846707__F1 Signal transduction by TGFBs and BMPs TGFB and BMP ligands induce formation of heteromeric complex between specific Type II and Type I receptors LIMK1 DROSHA SMAD4 RHO TF PMC8614664__F2 Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings COQ4 COQ3 COQ2 COQ10A COQ9 COQ6 PDSS1 COQ7 PARL COQ8B PMC6041399__F1 Schematic presentation of JNK signaling pathway in cerebral ischemia/reperfusion injury BAD HRK BAX PMC3966557__F1 RGS proteins in the regulation of GPCR, PTH, and Wnt signaling pathways during bone remodeling RGS5 CASR NFATC1 PTH RGS18 RGS2 RGS12 AXIN2 RGS10 PMC11657104__F1 Biosynthetic pathway of L-Homoserine in E ASPA CIT NR1A2 THRA GALP PMC4803542__F1 Monogenic Mouse Models of Autism Spectrum Disorders: Common Mechanisms and Missing Links UBE3A ARC PTEN BDNF RHEB PMC2808458__F2 Toll-like receptor signaling in cell proliferation and survival IL10 IRF7 MYD88 MTOR PMC3827118__F2 Hh signaling in mammals SUFU PTCH1 SMO PMC2808458__F1 Toll-like receptor signaling in cell proliferation and survival TBK1 IRAK1 TRAF6 IRF3 IRAK4 MYD88 PMC4414131__F2 Multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 VPS35 OGT GOLPH3 MAJN MTOR PMC3827118__F1 Wnt-dependent pathway responses APC LRP5 LRP6 PORCN ROR2 PMC12219892__F10 Pathways associated with DOX-induced cardiotoxicity HMGB1 IL6 MTOR SIRT1 PMC7142847__F1 Metabolic reprogramming in triple-negative breast cancer (TNBC) ME1 PGM3 HEL-S-30 PSAT1 F2 ASNS GPT HEL107 PHGDH HEL-S-162eP GLS PMC10141515__F5 Differentially expressed proteins of the glutamine metabolic pathway in ovarian cancer BCAT1 ASS1 ASL GLS PMC5535862__F1 Schematic model proposing a differentiated cell as the cell of origin of skin squamous cell carcinoma (SCC) CIC PTEN MTOR GRHL3 PMC9240209__F2 Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors TBK1 IRF3 TLR3 MAVS PMC2945552__F11 Proposed signaling pathway modulated by TH2-3 in LPS-induced RAW264.7 cells PDE4D CD14 COX2 MYD88 PMC6636823__F1 Canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC7097090__F3 Counter-regulatory renin–angiotensin system in cardiovascular disease SMAD2 PMC10474042__F2 Calcium signaling in efferocytosis MCU MERTK ORAI1 STIM1 CRBN PMC9502831__F1 Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review APC LRP5 SMAD6 LRP6 PMC7878452__F1 Glucose metabolism in the brain HEL-S-162eP PMC8847181__F2 Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer RELA FOXQ1 CXCL8 JAK3 FERMT2 TNF MTOR STAT3 PMC4186533__F6 Src family kinases in Gq- and Gi-coupled receptor signaling FYN HEL-S-11 LYN ARHA PMC8664592__F8 HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5 TBK1 TANK IRF3 MAVS PMC7552046__F6 Natural 5′ terminally deleted group-B enterovirus RNA forms can modulate type I interferon signaling pathway activation IRF7 CHAD IRF3 IFNAR2 IFNAR1 MAVS PMC7552046__F5 Group-B enterovirus proteinase activities impair type 1 signaling pathway activation in infected cells TBK1 IRF7 TRAF6 IRF3 TLR3 MAVS TAB3 PMC7590177__F1 Detection of poxviruses by anti-viral pattern recognition receptors (PRRs) leads to the activation of IRFs TBK1 CGAS TANK TLR9 TRAF3 TRAF6 IRF3 MYD88 MTOR TLR3 TLR8 TLR7 TLR4 TBKBP1 IL1B MAVS PMC7136464__F1 IFN-I and IFN-II signaling STAT1 STAT2 IRF9 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 PMC4157144__F3 L-Serine Biosynthesis PathwayDe novo biosynthesis of serine is crucial to provide the organism with sufficient levels of this amino acid PSAT1 PSPH PHGDH PMC8199451__F1 Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses ATF4 EIF2A XBP1 PMC8042134__F3 Factors produced in the obese breast microenvironment contribute to the growth of breast cancer TNF MTOR IL6R STAT3 PMC6057142__F1 Wnt/Beta-catenin signing pathway APC GSK3B LRP6 PMC6854528__F2 Model of the AhR signaling pathway HEL-S-62p AHRR AHR CYP1A1 PMC9163667__F2 Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury APC GSK3B LRP5 LRP6 PMC3690850__F7 Working model for rotavirus cell entry EEA1 ARHA ACTN4 CDC42 PMC4256868__F7 Isoprenoid metabolism in photosynthetic plant cells and its relationship to photosynthesis, glycolysis, respiration, and photorespiration HEL-S-62p CS IPP PMC5467707__F3 Pathway of Huntington’s disease enriched in target DEGs of DEmiRNAs of AD CASP3 HEL70 TBP UCP1 APAF1 HTT REST SIN3A BDNF POC1A BAX TAF4 PMC3923765__F2 BiNA: A Visual Analytics Tool for Biological Network Data CASP6 BAD CASP12 NTRK1 CSF2RB TNF CASP10 CASP3 NFKBIA TNFSF6 DFFB ATM APAF1 NFKB1 TNFRSF1A TNFSF10 BCL2 MAP3K14 TRAF2 BAX PMC5467707__F4 Pathway of AD enriched in target DEGs of DEmiRNAs of AD SNCA BAD CASP12 RTN3 RTN4 GSK3B TNF CASP3 APAF1 LPL APP CASP9 FADD APOE PMC5045435__F2 Notch signaling: its roles and therapeutic potential in hematological malignancies NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC9523540__F3 Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction ULK1 NRF1 MCU MTOR PRX TFAM SIRT1 BAX PMC6675305__F4 Genes enriched in the VS (shaded) are contained in the canonical pathway for Ras/MAPK signaling STAT1 BAD FYN MOS SRC BRK1 CRK PMC6416842__F1 Simplified overview of one-carbon metabolism pathway HEL-S-61p MTR MTRR PMC5664647__F1 Working Figure of the Angiogenesis Pathway Genes CXCR1 FLT1 NR1i1 KDR EGR2 EGFR CXCL8 IL8RB TNF TGFB1 IRS1 IL1B PMC6881465__F1 Animal cell cytokinesis PRC1 PLK1 ECT2 ARHA PMC8624911__F1 Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO STAT1 MRC1 TLR4 CXCL10 IRF3 MYD88 IRF4 STAT3 PMC4530521__F1 Mini but Mighty - microRNAs in the Pathobiology of Periodontal Disease AGO2 DGCR8 DROSHA PMC4262777__F4 Tumor-derived exosomes are secreted via a constitutive/inducible pathway that can be activated by a p53-mediated response RAB27B PMC4118469__F1 Molecular Mechanisms of Neurodegeneration in PD SIRT2 PINK1 LRRK2 FBP1 HTRA2 HEL-S-162eP PMC1351245__F1 Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice RDH5 RPE RDH11 PMC9441916__F5 Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy SOAT2 IL21R CCR5 RUNX3 c-fgr FCHO1 CTLA4 S1PR4 CD74 PTPN22 CBFB EED IFNG ITK SELPLG TBX21 LTA BCLAF1 TRAF1 PTPN6 MPEG1 HLA-DMB BRD4 PMC2527618__F4 Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways GSK3B NXN TCF7L1 PMC4826168__F2 DAB2IP in cancer EGR1 TRADD GSK3B DAB2IP SRC MTOR PMC7746447__F2 TRPV2 regulation is involved in cellular responses relevant to cancer IGF1 TRPV2 INS PMC8415548__F5 Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy GPX4 CISD2 SLC7A11 FTH1 FTL ISCU TFRC LPO HEL110 POR IPP HMOX1 TXN HEL60 SLC38A1 HEL-S-64p HEL-75 SLC3A2 ACSL3 TF GLS FASN PMC9316955__F2 Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity IL10 HIF1A IL1B PMC6703955__F4 Proteostatic regulation of Ci/Gli proteinsAll Ci/Gli proteins, except mammalian Gli1, have an N-terminal repressor (R), a central zinc-figure (ZnF) and a C-terminal activator (A) domain SUFU SPOP PMC10820833__F2 Cellular senescence pathways affected by Tax ATM SSB ATR PMC6703955__F1 Outlines of Hh signaling(A) In Drosophila, Ptc keeps Smo inactive, partly by promoting its internalization and degradation KIF7 SUFU GLI3 SMO PMC6563445__F2 The proposed mechanisms of IRF5 activation TLR8 PTMS CARD9 TLR7 TLR4 TLR9 IRAK1 TRAF6 SYK IRAK4 MYD88 NOD2 PMC4858804__F7 Recycling and regulation of eIF2 by eIF2B ELF2 ELF5 LBH EIF5 PMC9563910__F1 Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise RPE HEL-S-162eP PMC6859529__F5 Redox regulation of apoptosis under ER stress ATF4 EIF2A TRAF2 BAX PMC6703304__F3 Schematic picture of the type I interferon production and different nucleic acid sensors CGAS TLR9 IRF7 IRF8 DDX41 TRAF6 IRAK4 IRF3 MYD88 TLR7 TREX1 MAVS IFI16 PMC6859529__F3 UPR pathway under ER stress ATF4 EIF2A XBP1 PMC6703304__F2 Inducers and regulators of IFNA production by plasmacytoid dendritic cell PDC TLR7 TLR9 APC PMC10669635__F3 Partial epithelial to mesenchymal transition (p-EMT) and full EMT with associated biological markers CDH2 PMC6703304__F1 Interferon receptors and signalling STAT1 STAT2 IFNK IFNE IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IFNG PMC10669635__F2 PI3K-Akt signalling pathway MDM2 PTEN PMC9314177__F6 Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/Beta-Catenin Pathway RUNX2 TEF SP7 CEBPB PMC4307112__F4 Differentially expressed genes in appetite control pathway between grass carp before and after food habit transition from transcriptome analysis LEP PLTP NPY AgRP TRH LEPR DRD1 GAL GLS PMC3628402__F6 Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence RRM1 RRM2 MDM2 RPL5 PMC4307112__F6 Differentially expressed genes in digestion and metabolism pathway between grass carp before and after food habit transition from transcriptome analysis PLAT CTRL PIR INS FOXO1 CFTR PMC4858804__F1 Pathway for yeast cytoplasmic translation initiation ELF2 ELF5 EIF5 PMC4307112__F3 Differentially expressed genes in cell proliferation and differentiation pathway between grass carp before and after food habit transition from transcriptome analysis EGF MOS INS PMC8864631__F7 Therapeutic siRNAs Targeting the JAK/STAT Signalling Pathway in Inflammatory Bowel Diseases JAK3 JAK1 IFNG PMC3317991__F6 RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer BCL2 CDK4 MTOR PMC5594453__F3 Signaling pathways that are activated by TMEM16A in cancer EGF EGFR SRC PMC1395315__F1 Methionine-Homocysteine metabolism and related pathways CTH HEL-S-61p MTAP HEL-S-182mP DHFR MTRR TYMS MTHFS ADK PMC4482759__F3 From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry ACAD11 CPSF6 AP2A1 MAP2 PLK1 AMOT SFN HADHB SHKBP1 DNAJB1 TEAD4 LATS1 CIT NUDT21 RDX CCDC6 LATS2 TEAD2 TEAD3 PNMA2 SNTB2 NF2 HGS SPTAN1 CPVL PRKCI ANAPC1 AIP TANC2 P4HA2 WWC1 NEK4 STXBP4 RPA1 LONP1 ALG13 APC ENO1 SKP1 AJUBA SCRIB HEL-S-31 CACYBP MAP2K1 HELZ NUDC LMO7 DOCK7 PMC4158839__F2 The development of the auditory sense organ FZD3 SOX2 HEY2 FGF8 DVL2 SPRY2 PMC5833124__F1 CX3CR1-CX3CL1 signaling pathway and migration process of immune cells via their interactions CXCR1 ADAM10 CR1 ADAM17 PMC6352210__F4 Internalization and cellular trafficking of FGFRs PAK1 FGFR1 FGFR3 SRC FGFR4 FGFR2 PMC2234347__F2 CNX/CRT cycle OS9 EDEM2 EDEM3 PMC4766407__F7 Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation PRMT1 TRAF6 IL1R1 MYD88 JAK1 IL1B PMC4963347__F2 Schematic representation of de novo and salvage pathways for NAD+ biosynthesis NAMPT HEL-S-90n NRK PMC1395315__F5 Elevated Homocysteine is associated with atherosclerosis MMP9 LPL HMGCR CD36 PMC6363996__F7 Model summarizing the inhibition of the cGAS-STING pathway by MDV VP23 TBK1 CGAS IRF7 PMC11731210__F10 Work model MYBL2 E2F7 GC PMC7605163__F6 TGFB Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation PSAT1 ATF4 PSPH PHGDH PMC9658487__F5 Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses CCND1 PTEN MTOR PMC3694890__F8 Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks EPOR PLCG1 IRS4 VAV1 EGFR CSF3R PILRA IRS1 FYN FRS2 LYN PTPN11 ZAP70 GRAP2 GRB2 SRC SYK PTPN6 FLT3 SOS1 SHC1 LAX1 LAT STAT3 PMC8373148__F7 Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms CAMK4 ATF4 CACNA1C PMC9415972__F1 Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology TLR4 IL6 MYD88 TNF IL1B PMC8745448__F1 Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion ABHD6 FFAR1 LPA GAA CD36 PMC5713354__F2 Current possible strategies to bypass AVPR2 mutations responsible for X-linked NDI SCT EGFR AVP AQP2 ARHA AVPR2 PMC8621388__F1 Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands EGFR GRB2 MTOR FADD HK2 STAT3 BAX PMC10378552__F2 Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment SUFU PTCH1 SHH SMO MTOR PMC6859529__F7 Redox regulation of IRE1A to control UPR TRAF2 XBP1 PMC11360082__F2 Catechol estrogens synthesis pathway in humans and the possible homologs identified in schistosome species CYP1B1 CYP3A4 HSD17B1 CYP1A1 HSD17B3 CYP1A2 PMC9162805__F3 IKKE in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology PDE3B TANK IRF7 IRF3 PMC8377231__F1 Mechanisms and Boundary Conditions of Drug Memory Reconsolidation ATF4 EIF2A CDK5 PMC12104430__F7 The OMD-induced regulation in hDPSCs upon LPS stimulation NLRP3 OMD IL1R1 TNF PMC9243319__F1 Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine PARP2 PARP1 PARG PMC8729140__F8 Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming ADIPOR1 ADIPOR2 SIRT1 PMC4484411__F1 Genetic/molecular alterations of meningiomas and the signaling pathways targeted PLCG1 EGF CDKN2B CDKN2C NF2 CDK4 PTEN RB1 MTOR CDK6 STAT3 PMC6005538__F6 Plasmatic membrane toll-like receptor expressions in human astrocytomas PTEN MYD88 TIRAP PMC7534289__F1 Two-Signal Models of Costimulatory and Inhibitory Pathways CD80 PMC5743771__F1 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease STAT1 NLRP3 SUMO2 ABCG1 PIAS1 SYK GPS2 ABCA1 IRF-1 SUMO1 PMC5743771__F2 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease PREB ABCG8 ABCG5 ABCG1 LPL LDLR NPC1L1 ABCA1 TG PMC4979589__F7 MUC4 is negatively regulated through the Wnt/Beta-catenin pathway via the Notch effector Hath1 in colorectal cancer MUC4 APC GSK3B AXIN1 HES1 PMC9300463__F2 Expression analysis of candidate genes in S. nux-vomica (strychnine producer) and Strychnos sp. (diaboline producer) MAX SPNS2 SPNS1 PMC4621423__F2 Schematic diagram that gintonin-mediated in vitro cellular effects through LPA receptors in neurons and astrocytes is linked to in vivo pharmacological effects ChAT HEL-S-11 LPA ACHE PMC5660607__F7 Crosstalk of KDG molecular and network pathways DOK3 NLRP3 TLR4 SRA1 NCKAP1L GRB2 AIF1 GPSM3 MYD88 SOS1 DOCK2 PMC6157710__F1 Directing the use of DDR kinase inhibitors in cancer treatment MTOR ARID1A CDK6 WEE1 RAD17 ATM CDK2 TOPBP1 ATRIP CCND1 SMO CDK4 ERCC1 CDC2 ATR SETD2 CDK9 PMC3674242__F7 Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth LATS1 LATS2 PMC11612265__F3 Glycolytic reprogramming in macrophages orchestrates NLRP3 inflammasome activation in ALI/ARDS NLRP3 F2 PMC7461872__F3 Fve-type FIPs on the immune system, adapted from Hsu et al APC SRC CD83 CD80 PMC6429113__F8 Proposed model for role of MARK4 in regulating lipogenesis in pig placental trophoblast cells MARK4 NR1C2 DKK1 PMC11612265__F1 Possible activation mechanism of NLRP3 inflammasome NLRP3 TLR4 FADD MAVS GSDMD PMC2887259__F5 Signaling cascades that regulate A FYN IGF1 SLC18A2 GAB2 HEL-S-11 GSK3B BDKRB2 TRAF2 IRS1 VIP PMC6653805__F6 Autophagy in Adipose Tissue Physiology and Pathophysiology NLRP3 TLR4 ATG12 LAMP2 DKFZp686F0183 IL1B PMC7655160__F8 Graphical model displaying the mechanisms of ARHGEF11 in regulating cell cycle and EMT via activating Beta-catenin PMC3339894__F2 Putative molecular mechanisms of Wnt signaling, lipid metabolism, and IL-6 effects on insulin signaling in nonobese PCOS adipose tissue LIPE APC CD44 TG JUN IRS1 STAT3 PMC7759910__F2 SRC kinase during platelet activation CSK GRB2 SYK PLCG2 TLN1 HEL114 PXN PMC3218922__F6 Pathway generated by ingenuity pathway analysis with proteins identified as specific target antigens RPLP0 HEL70 NPM1 ENO1 UGDH EZR TNF LMNA HEL-S-7 RDX PRDX3 HEL-S-69p HEL-S-102 TUFM SEMA4D HNRNPD HEL-S-269 FH ANXA2 GRB2 FABP5 IMPDH2 HEL114 IL4 PMC7858073__F5 Signaling and molecular network mapping of genes differentially expressed in the ileal transcriptome of NCFM-colonized versus germfree mice (24 genes) using the Ingenuity Pathway Analysis software TAMM41 BATF2 MYC DUOX2 TPO IFNG ROMO1 CYB5B CAPN13 RNASE2 LETM1 P2RY4 IL10RA RXFP2 BTN2A2 CCL8 TNLG1B INSL3 TMPPE TNF HRAS C3AR1 DUOXA2 TAC4 DBP SHARPIN CCL23 GSDMC PER3 PMC10837142__F5 Terpenoid biosynthesis pathway in T SQLE MVD FDFT1 GGPS1 PMC10837142__F7 Peroxisome biogenesis pathway in T MPV17 PEX7 PXMP4 PEX16 PEX3 PEX13 PEX14 PTS PEX19 PEX6 PEX5 PEX2 PEX10 PEX12 PEX26 PXMP2 PMC10837142__F6 Common symbiosis signalling pathway in T RAD1 NUP133 NUP85 PMC8861971__F7 An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer TSC1 CDK2 MDM2 CDK4 RB1 PMC7646582__F1 Diagram illustrating the diagnostic features of cutaneous melanoma and uveal melanoma PLCB4 GNA11 KIT KPG_011 EIF1AX CDKN2A BAP1 PMC11724797__F17 KEGG NF-kappa B signaling pathway—Homo sapiens (human) CD14 EGF NGF TRADD LTB TRAF6 MYD88 TRIM25 CNTF EDAR COX2 LTA TLR4 BCR ATM BASH CYLD LYN LBP SYK LAT TIRAP PMC5837819__F2 CK1 in Developmental signaling: Hedgehog and Wnt APC LRP5 LRP6 SMO PMC12008652__F7 Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals RUNX2 BMP2 PTH SMAD1 TRPM7 PMC9521521__F2 Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma TGFBR1 GRB2 ARHA MTOR PMC12008652__F5 Cellular and molecular mechanisms revealing the potential effects of magnesium ions on bone repair MAGT1 TLR4 CTSK BMP2 NFATC1 LRP5 CREB1 TRAF6 LRP6 RAC1 SP7 TRPM7 PMC9120647__AF1 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo GSK3B CCND1 SRC MTOR AXL PMC10495745__F4 Activation of MAPK and TGF‐B‐SMAD signaling pathways in macrophages EGF SMAD2 ATF2 SMURF2 EGFR GRB2 SMAD4 ARHA MAP3K7IP1 PMC10953212__F4 Relationship between inflammation and NASH disease progression NLRP3 JAK1 STAT3 PMC6381062__F2 A working model of NPR1, NPR3, and NPR4 SUMO3 NPR3 PMC10495745__F3 Activation of PI3K/Akt and Notch signaling pathways in macrophages MAML1 TSC1 RBPJ GSK3B PKD1 PTEN FOXO1 RHEB PMC10953212__F2 Glucose–insulin signaling pathway GCKR ENPP1 GCK IRS1 FOXO1 FASN PMC10495745__F2 Activation of the JAK‐STAT signaling pathway in macrophages IRF9 TYK2 JAK1 PMC5133678__F14 ‘Apoptotic execution phase’ gene enrichment in cisplatin-treated samples HMGB1 CLSPN SATB1 HMGB2 PMC7277093__F1 Role of CBS and other enzymes in the regulation of mammalian sulfur amino acid metabolism CTH HEL-S-61p PMC10495745__F1 Activation of the NF‐KB signaling pathway in macrophages TBK1 TLR4 TRADD IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TRAF2 FADD PMC10953212__F1 Lipid metabolism in NAFLD PNPLA3 TM6SF2 APOB APOC3 HSD17B13 LPA MTTP MBOAT7 CD36 PMC9510030__F1 Molecular inhibition of RAS signalling to target ageing and age-related health MDM2 GRB2 IRS1 PMC10495745__F5 Activation of GPCR signaling pathway in macrophages STAT1 APC GSK3B LRP5 LRP6 ARHA CCL5 CCL2 RAC1 CDC42 STAT3 PMC9456310__F7 SP and KLF Transcription Factors in Cancer Metabolism GPR17 PRC1 PTGS2 UGDH KLF9 SP1 HEL-S-5 PMC9456310__F6 SP and KLF Transcription Factors in Cancer Metabolism FACL4 ERBB2 OGT KLF4 SP1 PFKP KLF8 HEL-S-5 PMC8429580__F2 NLRP3 inflammasome activation and cell death NLRP3 TLR4 TRADD TRAF5 MYD88 TNF TRAF2 FADD GSDMD BAX DFNA5 PMC4556964__F4 Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway PC LTB LPA PMC3311515__F1 Scheme for the intracellular renal RAS on the nuclear membrane ACE2 PMC11171484__F4 Systemic inhibition of TGFB signaling in the fibrotic lung by pirfenidone and localized inhibition of TGFB signaling in the fibrotic niche by bexotegrast (A,B) TIMP1 COL3A1 SMAD2 SMAD4 CTHRC1 PMC8997969__F2 Metabolic Reprogramming and Its Relationship to Survival in Hepatocellular Carcinoma PC ACACA LPA ACLY HEL-S-87p ADM CP PMC1963416__F1 Signaling mechanisms for the activation of HAT and HDAC NGF HDAC8 HDAC2 HDAC1 PMC8525887__F1 Schematic showing regulation of PAI-1 activation and its role in hepatocytes EPCAM PLG VTN MYC CCND1 PMC8087647__F3 autophagy in immune cells in the tumour microenvironment AGO2 ULK1 ARG2 MYC CIC BCL2 ATG101 ARG1 FOXP3 PMC8087647__F2 Impact of tumour autonomous autophagy on immunity CXCL5 CXCL10 CXCL9 IRF3 CCL5 CXCL12 AIM2 NBR1 PMC7247521__F6 Component-target-pathway-disease network PTGER2 SOAT2 NDN REN PGR RIC1 DES DRD2 POR MTTP RXRB RARA RARB NR1i1 APOA2 ME1 IL13 TES PIGR TNF CKMT1B CNR2 FADS2 NR1C2 CKMT2 HEL-S-20 HEL-S-29 PMC8699356__F1 Interleukin (IL)-9 Supports the Tumor-Promoting Environment of Chronic Lymphocytic Leukemia STAT1 BAD GRB2 JAK3 IRS1 STAT3 PMC4488505__F5 Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin SOCS2 MAP2 NPM1 MAPK8 MAPK7 CDKN3 AKT1S1 EIF2AK2 PTEN MTOR CCNE1 RPS6KB1 RET MAP2K1 CDK2 LCK PTK2B SRC BMX BCL2 SYK JUN PMC8087647__F1 Machinery of canonical and non-canonical autophagy ULK1 ATG12 ATG3 AMBRA1 WIPI2 ATG101 UVRAG ATG14 PMC8429580__F1 NLRP3 inflammasome activation and cell death NLRP3 TLR4 MYD88 FADD GSDMD PMC3858477__F4 Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish RAB38 MLPH FANCD2 ASCL1 CRY2 MAPK3 SMAD2 TBX3 ETV4 MAPK14 CRHBP TPH2 CPT2 OLIG2 HES1 FGFR1 EPX BCR TBR1 GCHFR PDCD11 LMAN1 SDHA FEV ATP6 GFAP FGF13 GAD1 NDRG4 IRX2 AVP MPZL2 CCNG1 KCND3 SGPL1 KLF2 RND1 MSI2 NEFL HEL-S-302 INA PDX1 CALB2 HLX CS HEL-S-101 GPX1 JAG2 MFNG GCG CDC40 SMPX ISOC1 FOXF1 BACH2 F3 MTDH IRX1 IRX4 SYT4 EHD2 CSDC2 VHL CDC37 ARHA MPZL3 OSBPL9 KCNIP3 ISL1 SPRY2 FOXN4 CTSC FANCL STAT3 PMC3952878__F4 FAK functions in cancer stem cells SOX2 APC GSK3B MYC LRP5 CD44 SHH LRP6 MTOR PMC3313462__F4 Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes TH RRP1 HK2 PMC4964743__F3 Regulation of HER3 and downstream signaling GRB2 PTEN MTOR NEDD4 PMC12217143__F7 TgFLP12 function in Toxoplasma gondii lipid metabolism ELOC ELOA LPA PMC5865879__F1 Chemokine signaling pathway significantly enriched in differentially expressed genes ARHH SHE DOCK2 PREX1 CRK PMC8888875__F2 Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis MAF COL3A1 KEAP1 SMAD2 APC SMAD4 TNF COL1A1 IL1B IFNG PMC4800799__F7 Model depicting the proposed effect of starvation on microRNA in cancer cells PC PLD2 PMC5556034__F6 Simplified scheme of the enzymes and transcription factors involved in de novo lipogenesis pathway ACACA ELOVL6 FASN PMC4403007__F3 Intricacies of cardiac damage in coxsackievirus B3 infection: Implications for therapy TLR7 IRF3 TLR3 PMC4725058__F2 Length of interaction alters the activation of specific transcription factors FOS LCK ZAP70 UNK JUN LAT STIM1 CDC42 PMC6689553__F4 Proposed metabolic pathway of the relevant eicosanoids GPX4 GPX1 ALOX15 PMC8873175__F1 Therapeutic Potential of Glutamine Pathway in Lung Cancer SLC38A3 KLF2 NUDT21 DHODH GLS PMC12015589__F7 Schematic diagram illustrating the beneficial effects of IL-7 during porcine early embryonic development SOX2 BCL2L1 BAX PMC6387269__F3 For using mTOR in PD treatment PTEN MTOR RHEB PMC8964978__F1 IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment ADAM10 ADAM17 STAT3 PMC4618674__F2 Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans TERF2 HEL-S-15 ERF RHO POR CP CDC42 PMC3435478__F2 Age-related alterations in receptors and signaling molecules of CD8 T cells SOCS3 CD27 CSK IL7R PMC8872633__F4 Protein cysteine palmitoylation in immunity and inflammation PLCG1 ITK LCK ZAP70 LAT PMC5182094__F2 Biosynthetic pathway connects cryptic ribosomally synthesized posttranslationally modified peptide genes with pyrroloquinoline alkaloids HAL AMT BAX PMC6559733__F1 Hypothesized therapeutic role of blocking IL6 pathway in Sarcoidosis IL6 MTOR IFNG PMC7412712__F2 Schematic description of TRAIL signaling cascade and interaction of lncRNA APAF1 BIK BCL2 POU3F3 FADD PMC3998825__F1 Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection IL21R IL13RA1 IL33 KLF4 IRF4 PMC3263596__F3 TGFB pathway in NetSlim TNC MMP12 ROCK1 FOS SMAD2 APC HGS SKI CDC42 ITCH TERT MAFA PMC6947814__F3 Regulatory roles of cellular IRES trans-acting factors (ITAFs) in EV-A71 translation FBP2 FBP1 PMC3772106__F1 How are STAT1 and cholesterol metabolism associated in antiviral responses? STAT1 CH25H TLR3 PMC10540347__F10 SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3B signaling pathway through P53 SQLE GSK3B PTEN PMC7756907__F1 One ring to bring them all and in the darkness bind them: The Trafficking of Heme without Deliverers. HP CD163 ABCG2 FLVCR2 HEL-S-162eP PMC8992556__F1 Intracrine androgen biosynthesis and drug resistance HSD3B1 HSD17B2 HSD17B4 AKR1C2 CYP17A1 HSD17B6 PMC7023715__F7 Activation of the PDGFRAlpha-Nrf2 anti-adipogenic signaling pathway impairs adipocyte differentiation in Nck1-deficient BM-MSCs PDGFRA HMOX1 NCK1 PMC7381711__F3 Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19) TFPI APC ACE2 TF PMC6429018__F8 Knockdown of PCAT-1 inhibited cell proliferation, metastasis, and promoted cell apoptosis in ECC cell lines WNT1 GSK3B PMC3584589__F9 Two mechanisms by which miR-200a regulates the activity of Beta-catenin ZEB2 PMC4872787__F6 IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer SOX2 BMI1 STAT3 PMC3338086__F1 Canonical and non canonical NF-kB pathways and related drugs inhibition BCR RELA RELB CD40 RHD PMC3068560__F4 Proteome of sickle cell disease: insights from exploratory proteomic profiling TCP1 PLG RAB8B PMC7836100__F2 Structural changes capture multiple regulatory events in yeast responding to osmotic shockA schematic of the yeast HOG-MAPK pathway and its links to glycolytic and glycerol biosynthesis pathways HEL-S-49 F2 ENO2 GPD1 HEL-S-68p PMC7255347__F1 Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19 TBK1 STAT2 IRF7 IRF9 IRF3 MYD88 TLR3 IFITM1 RNASEL STAT1 TLR8 RNASE1 TLR7 TLR4 TYK2 JAK1 IRF-1 MAVS PMC3877020__F4 UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes POLD2 RBMS1 MMP9 MTRR HEL-S-273 TYMS RHOB CELSR2 TAGLN MDH2 PMC5220330__F1 Interleukin-33 (IL-33)/ST2 signaling pathway IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC2817430__F1 Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature DHCR7 EBP DHCR24 TM7SF2 IPP PMC2278091__F1 F igure 1.— EGFR GRB2 VHL SMAD4 SRC ARC RHO STAR PMC7246871__F5 Closer examination of all drugs and pathways associated with the gene TNF PLAUR PGR NF2 TNF PPARG PBR PMC5454339__F3 Suppression of BCR signaling is detrimental to growth and sensitizes B-ALL to dex TCF3 CSK MAPK14 NRAS RRAS MAP2K2 MTOR BTK IL7R SYK MAPK1 MEF2C PIK3R2 PMC8781679__F2 An Updated Review on the Modulation of Carbon Partitioning and Allocation in Arbuscular Mycorrhizal Plants PMC9667637__F3 Neutrophil extracellular traps in cancer progression, metastasis and therapy CXCR1 TLR4 TLR9 MPO PMC11822647__F8 Schematic image shows the role of neuronal CTSS in the process of aging and Alzheimer's disease (AD) CTSS CX3CR1 CX3CL1 STAT3 PMC5585150__F1 Pro- and antitumoral effects of tumor-immune cell heterotypic GJICs IFNA1 TNF PMC7140419__F4 Main signaling pathways playing role in autophagy activation TSC2 TSC1 ATG101 MTOR SIRT1 PMC9667637__F2 Neutrophil extracellular traps in cancer progression, metastasis and therapy TLR4 TLR9 CCDC25 PMC8040471__F7 Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation BCL2 BAX PMC7330710__F1 Representation of some of the metabolic adaptation and reprogramming of cancer stem cells GOT2 HEL-S-32 FASN PMC5514546__F2 KEAP1-NRF2 Signaling and Autophagy in Protection against Oxidative and Reductive Proteotoxicity HMGB1 ATG3 ATG10 PMC2990540__F1 APC/C inhibition is regulated by signalling within the cytoplasm (a) and at the kinetochore (b) MCC CDC20 KNL1 UBE2S PMC9694162__F6 PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway in Resveratrol Alleviation of Zearalenone-Induced Oxidative Stress and Apoptosis in TM4 Cells KEAP1 BCL2 BAX PMC8889620__F2 Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential SOX2 MMP9 LDLR CCND1 CD226 MTOR CDHR3 STAT3 PMC9114649__F3 Influence of Arginine Methylation in Immunity and Inflammation NFKBIA CXCL10 TRAF1 CCL20 TNF IL1B CXCL11 PMC9457753__F2 Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use CD14 TRPV4 IRF7 TRAF3 TRAF6 IRF3 MAP3K7IP1 TRPV1 TICAM1 NLRP3 COX2 TLR4 LBP TRPA1 MLSN2 TIRAP MAL PMC9114649__F2 Influence of Arginine Methylation in Immunity and Inflammation TH NFKBIA PRMT1 MHC2TA APC PMC2897958__F4 Regulation of Lipid and Glucose Metabolism by Phosphatidylcholine Transfer Protein UCP1 CPT2 TG PMC5797008__F5 Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer NF1 IGF2 SRC PMC9114649__F4 Influence of Arginine Methylation in Immunity and Inflammation PRMT1 CARM1 PRMT7 IRF7 CXCL10 CCL5 IFIT1 FOXP3 PMC4115244__F3 Pak Signaling in the Development and Progression of Cancer BAD MYC ARHA CDC42 PMC1553197__F8 Model of CISK-mediated inhibition of CXCR4 sorting and degradation PI3 CXCR4 CXCL12 PMC6208316__F2 Analysis of pathways responsible for the expression of TGFB target genes MYB IRAK1 LAT2 IRAK2 SMAD2 TRAF6 CD244 MYD88 IER3 TNFSF14 IL1RL1 JUN KLF6 PLK3 LYZ VEGFA SMURF1 CD69 CASP3 MAPK13 GIG8 SMURF2 GRB2 IL18RAP NFKBIE PMC9105177__F2 Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection TBK1 IRF3 TRIM25 MAVS PMC7471650__F1 Signaling pathways underlying Sirt3-mediated regulation of autophagy MTOR SIRT3 PMC5539950__F1 Oxidative estrogen metabolism causes DNA adduct formation CYP1B1 CYP1A1 HEL-S-22 PMC4758903__F1 MicroRNA-based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer NF1 GRB2 SPRED1 SPRY1 PTEN PMC8351592__F2 Type I Interferon Induction in Cutaneous DNA Damage Syndromes CGAS TREX1 IRF3 PMC9367737__F2 Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies GSK3B MDM2 CDK4 BMI1 PTEN CDK6 WWOX PMC9448891__F6 Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells STAT2 IRF7 IRAK1 CXCL8 IRAK4 IRF3 IL6 MYD88 TLR3 STAT1 TLR4 SERPINA1 IL1B PMC2358943__F1 Metabolism of PtdIns(4,5)P2 by PLCG and PI3K TSC2 PI3 TSC1 BCL10 TEC PTEN MTOR PMC9222172__F3 Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation IL10 TLR4 IRF3 MYD88 TIRAP STAT3 PMC9470863__F1 Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth CD80 MYD88 PMC8600858__F4 Transcriptome provides potential insights into how calcium affects the formation of stone cell in Pyrus ERF CAD PMC9569901__F1 Genome-Wide Identification, Characterization and Expression Analysis of Toll-like Receptors in Marbled Rockfish (Sebastiscus marmoratus) CD14 CTSK TLR9 TRAF3 IRF3 CD80 MYD88 TNF TLR3 TIRAP PMC6289770__F3 The lipoyl relay pathway of lipoyl-protein assembly.A LIPM LIPE LIPA LIPI PMC8120713__F4 Functional conservation in genes and pathways linking ageing and immunity BMPR1A ACVR1C SMOX EGFR ACVR1B IL6R SMAD1 PS1TP5BP1 DKFZp781O1323 PMC4055924__F6 CD28 signaling in myeloma cells CD80 PMC6478827__F6 Cell cycle regulation in GCs of small follicles MYC MTOR CCND2 PMC11607693__F1 Genome engineering Drosophila TGFB/BMP signaling SPARC SMAD2 CFP TTLL12 PMC10945329__F13 MSC-EV effect on bone regeneration IL10 NLRP3 WNT3A BMP2 MSC IL1RN IL11 PTH TNF HIF1A CLEC11A NID1 PMC4326213__F3 Immune-initiated, complement-mediated erythrocyte destruction in cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS) HEL-S-62p PMC10945329__F10 Exosomes generated from human adipose mesenchymal stem cells reduce hepatic fibrosis by suppressing the PI3K/Akt/mTOR signaling pathway and altering choline metabolism CHPT1 MTOR PMC7139953__F3 Mucins signaling in the benign and malignant pathologies of the colon MUC1 MUC13 FOXO3A ERBB3 CD44 LRP6 TRAF6 MUC2 ERBB4 MUC4 ERBB2 SRC STAT3 PMC8787114__F2 Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis ROCK2 FYN ROCK1 GRB2 SRC SHB RHO CDC42 PMC7049507__F4 Analysis of miRNA‐mRNA regulatory network concerning Phospholipase D signaling pathway TH KITLG RAPGEF4 PMC7589708__F2 Wnt non-canonical signalling pathways DAAM1 ROR2 RHO PMC12149821__F1 Representation of phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin sequential signaling pathway in breast cancer BAD MDM2 CCND1 PTEN FOXO1 PMC3045367__F1 Exploring the Evolutionary Relationship of Insulin Receptor Substrate Family Using Computational Biology IRS4 IRS1 PMC6407099__F4 Role of Itch in Type I non-canonical Hh pathway PTCH1 SMO ITCH PMC6407099__F3 Role of Itch in canonical Hh pathway NUMB SUFU PTCH1 GLI3 SMO ITCH PMC2634101__F1 Model summarizing some of the pathways described in this review leading to chemotaxis and cell motility GC PTEN CDC42 PMC5739549__F1 Mechanisms leading to transitory or sustained PD-1 expression in activated and exhausted T cells APC TIGIT PMC3977192__F8 LTP pathway components and interacting proteins: response in hippocampus TH SNCA EGR1 BAD FOS CHP2 PPP3R2 CAMK2G MTOR RCAN1 DYRK1A ERBB4 FYN CHP1 APP BCL2 RAF1 ARAF PMC8085045__F7 Alantolactone inhibits cervical cancer progression by downregulating BMI1 RIPK3 BMI1 CDH2 STAT3 PMC3260807__F4 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health DDR1 BRAF ATM MDM2 CIC PTEN PMC3260807__F2 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health BAD MEI1 EGFR MDM2 SHE SRC MTOR RHEB PMC3260807__F1 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health TSC2 TSC1 PTEN EIF4E RPS6 MTOR RHEB PMC6504273__F1 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway network for Kashin-Beck disease (KBD)-related genes F13A1 F2R F8 F9 PROC RYR2 C9 HEL-S-108 HEL-S-78p CFD CFH APAF1 TNFSF14 LDLR F11 MASP2 SERPINA1 BAX FGA ITGB3 CFB ITGA2B PLG MBL2 ITGB1 HLA-C ITGA6 CTSC TNR PLA2G4C ADCY9 PMC2490815__F4 IL-12, IL-23 and IL-27 are heterodimeric cytokines signals through Jak-Stat pathway and induce Th1/Th17 differentiation and T-bet expression in T cells STAT4 TYK2 IL23R IFNG STAT3 PMC9237599__F7 Exosomes-mediated tumor treatment: One body plays multiple roles BAD SMAD2 BAX PMC2490815__F3 Regulation of NFKB pathway by PPAR agonists in CNS diseases CD14 TLR4 TLR9 LBP TRAF6 CD40 MYD88 PMC3750075__F1 ACK1/TNK2, a non-receptor tyrosine kinase (NRTK), represents a paradigm of tyrosine kinase signaling that appears to be addictive in cancer cells EGF ERBB2 WWOX PMC5220089__F4 IPA-mapped CVD pathway for the 1890 compounds distributed in the top 10 herbs NMUR1 PTGS2 DAP SRC HCAR2 ZNF675 TAOK2 PMC3251006__F5 ECM-receptor interaction and focal adhesion pathway CD6 HEL-S-28 SHE PTEN BAG1 PMC8931742__F1 Schematic depicting the ER stress response signaling pathway after SCI ATF4 XBP1 PMC8146469__F1 Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) MRGPRX2 EPO IL33 VIP PMC12111248__F9 Cdh23 regulating rod cell calcium ion transport (image created by Figdraw) CDH23 GNAT1 GC RHO GUCA1B PMC10929194__F1 Canonical pathways downstream of KRAS mutations OTUB2 TBP RALA RALB MTOR JUN PMC10929194__F3 Signaling pathways in the TME TXNIP CXCL3 AXL PMC11353192__F7 Lactate and LOX regulation of the HCAR1-RAS/PI3K signaling cascades GRB2 SOS1 TF HCAR1 PMC5084369__F5 PHBHHx synthesis pathway with R-specific enoyl-CoA hydratase SCAI C6 PMC9289230__F1 Neutrophils: New Critical Regulators of Glioma HMGB1 DDX5 PMC4823071__F7 In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment ATM FOXM1 BARD1 PMC3978517__F2 The replication checkpoint pathway activated following DNA damage TOPBP1 ATRIP ATR H2AX PMC3059437__F1 Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk SHMT1 DHFR TYMS PMC8361660__F6 Early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies CDK2 CDK4 RB1 CCND3 CDKN2A BRCA1 CCNE1 PMC8790521__F2 Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect GC CTLA4 FOXP3 PMC9353726__F8 Network of deregulated genes that were differentially expressed upon c-MYC inhibition after lomitapide treatment as determined by Ingenuity Pathway Analysis. Color code: green, downregulation; red, upregulation BAD BIRC5 PARP10 MYC DDIT3 BCL2L2 TP53INP1 NFKBIA BTK NFKBIB NFKB1 ARF5 SP9 PMC2913512__F2 G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery MDM2 RHO GPR87 PMC9637672__F12 Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules METTL1 FGF23 NR1i1 CYP24A1 PTH CRTC2 PMC6433803__F2 Influence of non-oncogenic viruses on the components of non-canonical NFKB signaling TRAF3 RELB CCL19 TRAF2 MAVS PMC6667742__F7 A model demonstrating the multiple platelet activation pathways inhibited by the methylated metabolites of quercetin SYK PLCG2 LAT PMC6433803__F1 Non-canonical NFKB activation pathway TRAF3 RELB TRAF2 PMC8652378__F1 Oxalate synthesis pathway and molecular mechanisms leading to primary hyperoxaluria HOGA1 PMC3684282__F10 Schematic of myelin-mediated activation of the TGFB signaling pathway and downregulation of Smad2 by SLPI SMAD2 TGFBR1 TGFBR3 SLPI PMC7523359__F7 Roles and locations of CCND2 and CTNNB1 in Hippo signaling pathway and HPV infection pathway GSK3B CCND2 PMC4001324__F1 Simplified overview of the receptor tyrosine kinase (RTK)-RAS and RAS-related RHEB signaling pathways NF1 SHOC2 PTEN SOS1 MTOR RHEB CBL PMC3502886__F1 PI3K/Akt/mTOR pathway regulates central carbon metabolism PTEN MTOR CIT PMC7532541__F8 AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway AFP CASP8 FADD PMC9145061__F1 Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma SMAD2 CMTM6 EGFR SMAD4 CDC37 PTEN TSGA10 PMC4915121__F1 Conserved longevity-regulatory components of insulin/IGF-1 signaling pathway in C PMC6073358__F9 Signaling pathways were regulated by HSAF GSK3B CDK4 CDK6 PMC2683723__F6 Insulin–EGF signal integration PIR EGFR SRC PMC3939313__F1 Quantitative Lipid Metabolomic Changes in Alcoholic Micropigs with Fatty Liver Disease PC SCD TG PEMT PMC3499189__F2 Synopsis of major pathways activating mTORC1 TSC2 TSC1 IGF1R IGF1 IRS1 LAT RHEB PMC4077447__F2 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy MTAP MTR APRT PMC3499189__F3 Aberrations of PI3K-Akt-mTORC1 signaling pathway in prostate cancer TSC2 TSC1 IGF1R IGF1 PTEN IRS1 LAT RHEB PMC9125579__F5 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues ME1 HEL-S-26 CS PC FH NOX4 NNT ME3 CIT FASN MAL PMC11900999__F3 This figure shows the role of NETs in AS and its related mechanisms NLRP3 HIST1H1E HNF4A TLR9 TFPI MPO VWF PMC9125579__F4 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues TRPC1 HEL-S-11 MCU MAL PMC11900999__F2 This figure shows a schematic diagram of the molecular mechanism of neutrophil suicidal NETosis MPO CDK4 CDK6 GSDMD HEL-S-162eP PMC4519337__F3 Transcriptome Profiling of Wild-Type and pga-Knockout Mutant Strains Reveal the Role of Exopolysaccharide in Aggregatibacter actinomycetemcomitans NAGK NAGA MPL PMC4589489__F3 Schematic of the ERBB(EGFR)/KRAS/BRAF/MAPK signaling axis, and its connection with the PI3 Kinase pathway EGFR PTEN MTOR PDPK1 PMC9583506__F2 TRIM family contribute to tumorigenesis, cancer development, and drug resistance TRIM11 TRIM16 TRADD TRIM46 TRIM21 SMAD2 SMAD4 PTEN MTOR TRIM59 TRIM67 TRIM52 TRIM66 TRIM58 TRIM10 TRIM69 ZNRF3 TRIM71 TRIM2 APC CD44 TRIM8 TRIM6 TRIM62 TNF TRIM29 TRIM25 TRIM39 TRIM26 TRIM23 TRIML2 TRIM13 TRIM14 TRIM32 TRIM15 TRIM28 TRIM24 TRIM27 TRIM44 TRIM47 FADD TRIM37 SOCS1 PMC4034385__F1 Chromatin modifications as therapeutic targets in MLL-rearranged Leukemia ELL3 DOT1L BRD4 PMC4491517__F1 Schematic diagraming central role of pyruvate in glycolytic, citric acid cycle (CAC), and accessory pathways TSC2 TSC1 PC OGT MTOR CD36 PMC10921743__F10 AMPK involvement in central sensitization of chronic migraine TNC UHRF1 ARG1 PMC3912804__F1A Hedgehog signaling pathways in vertebrates-without hedgehog ligand SUFU PTCH1 SMO PMC8114223__F1 Implications of the germline variants of DNA damage response genes detected by cancer precision medicine for radiological risk communication and cancer therapy decisions PALB2 FANCD2 BRIP1 RAD51D MRE11A BRCA1 ATM BRCA2 RAD50 FANCM RAD51 H2AX XRCC3 FANCE RAD51B FANCG FANCF RAD51C PMC4496349__F6 MiR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer HIC2 ING5 RBPJ NRF1 MAX NFKB1 MYC PMC11125340__F7 Platelet-Derived Growth Factor Receptor Beta and JAK2/STAT3 Pathway RUNX1 CDK2 CCNB1 CCND1 RHO CDC2 CCNE1 STAT3 GATA1 PMC8395054__F3 CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy IGF1 CCND1 RB1 PMC4836462__F5 Morphogens involved in BBB development and integrity influence signaling of common pathways KIT MDM2 CCND1 RHO PTEN EIF4EBP1 MTOR CDC42 PMC7314312__F2 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism NADK PFKFB2 TXNIP ACLY CAD HEL107 PMC7314312__F1 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism TSC2 ATF4 MYC PTEN RHEB PMC8714965__F5 Compendium of Information on the Lysosome TSC2 ULK1 TSC1 SLC38A9 ARL8B PMC7314312__F4 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism ATF4 CAD HEL107 MTHFD2 PMC7314312__F5 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism HEL-S-26 NADK DHFR ACLY NDP FASN PMC8874499__F3 Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods ITPR2 KCNN3 PLCB3 GNG13 REN APLN MAPK3 PRRT2 KCNN1 VDAC3 TRPV1 PLCB2 TPCN1 COX2 GNB3 IL18 GJD2 MAP2K1 HEL-S-11 GJA1 KCNN2 RAF1 TRPA1 TAS1R2 PMC10376127__F2 New Insights on the Uptake and Trafficking of Coenzyme Q COQ8A FDX1 COQ10B FDX2 COQ10A IPP COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 ALDH3A1 PDSS1 COQ7 FDXR COQ8B PMC10376127__F1 Coenzyme Q functions HEL-S-62p CHDH PRODH DHODH NQO1 PMC11519791__F10 An illustration of the proposed role of cholinergic and calcium signaling pathways in ISIAF and WK treatment in neuronal and non-neuronal (cardiac) systems ChAT CHRM3 ACHE PMC4538308__F1 The mechanism by which DHA may interfere with the molecular signalling by activating glycolytic phenotype VHL PTEN NR1C1 PMC3912804__F2D Hedgehog signaling pathway in cancers -Type IIIb-Reverse Paracrine Ligand-dependent cancers PTCH1 SMO PMC3912804__F2C Hedgehog signaling pathway in cancers -Type III- Paracrine Ligand-dependent cancers PTCH1 SMO PMC4933505__F1 Emerging role of coagulation proteases in kidney disease PC TFPI F2 APC TF PMC3912804__F2B Hedgehog signaling pathway in cancers -Type II- Autocrine Ligand-dependent cancers PTCH1 SMO PMC3912804__F2A Hedgehog signaling pathway in cancers-Type I-Ligand-independent cancers PTCH1 SMO PMC5796261__F1 TREM2-DAP12 signaling CCR7 SYK PMC7047281__F3 Interaction network of differentially expressed miRNAs (DERs) and genes EREG FOS IGF2 EGFR CLEC3B MAPK3 NTS TNF HRAS IRS1 INSR CCND2 GRB2 JUND CDK4 CDC2 JUNB JUN SHC1 CTSW RBL2 PMC7862576__F7 Mdfi overexpression promoted C2C12 cell differentiation and positively modulated fast-to-slow-twitch muscle fibers transformation CS MDFI F5 GNG2 TNNI1 HEL-S-87p PDK4 CYCS ACADM ACOX1 PMC9701405__F6 Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure ANGPT2 HGF REN SHE CCL2 TNF POR MMP3 VEGFC FLT1 CNR2 MMP2 ERBB2 CRP TGFBI PMC3962345__F4 Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice EGR1 MARCKS GRIN1 CDK5 CDC42 PMC8526972__F1 Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology TH PNMT DBH PMC3005418__F8 Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery PRC1 SOX2 HDAC2 POLI PMC2801289__F1 UDP-galactose synthesis in L PMC5580928__F1 Post-translational Modifications (PTMs) that Modulate the Retinoic Acid-Inducible Gene I (RIG-I)-like receptor (RLR)–Mitochondrial Antiviral Signaling Protein (MAVS) Signaling Pathway TBK1 USP4 USP15 USP21 RNF122 MEX3C RIOK3 IRF3 TRIM4 TRIM25 RNF125 RNF5 CYLD MAVS PMC3538326__F7 Proposed mechanisms of the reduced activation of G3139 in RIT-INPs TLR9 BCL2 CD40 IL6 CD80 MCL1 PMC7435027__F4 Illustration of the effects of acetaminophen on glutathione, antioxidant processes, and metabolic processes ME1 HEL-S-26 ME2 MTHFD1 PMC6397284__F4 Promoter hypomethylation of genes involved in myogenesis, structural dynamics of muscles and CDC42 signaling FGD1 CDC42 PMC7443979__F6 The molecular mechanism of the ascorbic acid anticancer effect EGLN1 TF TFR2 SDHB PMC4400383__F3 Insulin binding causes activation of the insulin receptor (IR), which phosphorylates different substrate adaptors such as the insulin receptor substrate (IRS) TSC2 PTEN EIF4E RHEB PMC3532605__F7 NFKB signalling pathway EGF NGF RELB PLCG2 TLR10 TLR3 FLT1 LTA RELA ZAP70 CD40 TGFBR3 TGFA TIRAP PMC11624796__F7 Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases CXCR4 TRAF6 CXCL12 ITCH PMC3758882__F1 Normal complement activation cascade and its regulation HEL-S-62p C9 C4B_2 VTN C7 C6 PMC6358298__F3 PTEN- and IPMK-mediated nuclear phosphoinositide signaling through SF-1 INS IPMK PTEN PMC4871119__F1 (Adapted from Alinari, Quinion, and Blum BTK BCR CXCR4 CD19 PMC5374451__F3 Molecular signaling involved in nephrogenesis FRAS1 SIX5 SEMA3A SALL1 BMP7 SPRY1 ROBO2 SIX1 WT1 SLIT2 LMX1B BMP4 SIX4 FOXC1 HOXD11 RARA RET EYA1 WNT4 GDNF SIX2 GATA3 PMC4545518__F6 Simplified schematic of the canonical Notch signaling pathway GNE RBPJ HES1 PMC2884164__F5 Significant signaling pathway networks mined from pituitary adenoma comparative dataset KL MYCL PMC5300302__F7 The trans-sulphuration pathway coupled with glutathione synthesis CTH MAT1A PMC2915700__F6 Schematic representation of the line of events by which HA modulates the leukocyte-EC interaction CD44 HAS2 IL1B PMC9678227__F9 Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NFKB signaling pathway SOCS3 IL1B STAT3 PMC4638034__F3 Signaling pathways HEL-S-61p PC EGFR MTHFD1 STAT3 PMC3528620__F4 Chemokine Signaling Pathway from the KEGG database (ID: mmu04062) overlaid with log2 fold change values for genes differentially expressed between DBA/2 and C57BL/6 at day 14 PRKCE PRKCZ ARHA PMC6277787__F12 LPS signaling pathway in teleost macrophages NOD1 NOD2 PMC2884164__F9 ERK/MAPK signaling pathway that is involved with pituitary adenoma comparative-proteomic data BAD MOS ATE1 PMC3607163__F2 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential DAAM1 ARHA PMC3607163__F1 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential TBP APC GSK3B LRP5 CCND1 LRP6 DVL1 PMC6542591__F1 Adaptive and pro-apoptotic pathways of the UPR ATF4 EIF2A XBP1 PMC4554646__F2 Proposed biosynthetic pathway of the prodiginines and the related 4- m ethoxybipyrrole, YP1 ME1 HBM PIGT SCO1 PIGC PMC2634657__F2 Leptin Neuroprotection in the Central Nervous System: Mechanisms and Therapeutic Potentials EGR1 SOCS3 EPO PDK2 GSK3B GRB2 BDNF FOXO1 PMC8621753__F3 Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells ASMT SIRT1 AANAT SIRT3 PMC12067801__F4 ANO1 participates in various signaling pathways EGFR MTOR PMC8664842__F8 Working model of KDM6B inhibition in neuroblastoma CTCF CCND1 CDK4 EZH2 CDKN2A KDM6B CDK6 PMC6857641__F1 The tryptophan catabolism pathway IDO1 KYNU KMO TDO2 PMC5836032__F3 Outline of melatonin biosynthesis in the fish pineal gland ME1 SHD AANAT PMC5481368__F1 Scheme tentatively summarizing the involvement of ACBD7 and its related product NDN in the effects of leptin in the ARC NDN POMC ACBD7 NPY AgRP MC4R PMC8987581__F8 Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway COX2 TLR4 IL1B PMC4975561__F1 Roles of the PtdIns(3,4,5)P3/Akt pathway on insulin signaling in liver fat and muscle tissue with representative substrates indicated TSC2 INSIG1 PTEN PMC2811067__F2 Some of the stress response transcription factor pathways with homologs in N MAF AHR KEAP1 HIF1A PMC6385390__F4 Networks representing protein-protein interactions in differentially regulated proteins from the NOD1 (HS578T/NOD1) (a) and NOD2 (HS578T/NOD2) (b) experimental groups AHNAK RTF1 NOD2 STAT5B SEC23B CADM1 NOD1 ATXN1 RRM2 ASCC1 MYBBP1A TPP1 PDLIM3 NIFK SVIL RPL32 AKAP12 RPL13a RPL36AL KCTD12 FTL MAPRE2 RPL6 RPL18 RPL4 RPL15 GC20 HLA-B RAB1A SDF2L1 RSL1D1 ALDH1A3 HEL-75 FYCO1 HNRNPUL2 SHCBP1 RPL7 BRIX1 PMC2269037__F3 PI3K/AKT signaling pathway activated by 3Alpha-diol TSC2 BAD PTEN EIF4E RHEB PMC6895449__F7 Illustration of the NEK2/Beta-catenin/Myc/KDM5B/H3K4me3 pathway KDM5B NEK2 ME3 PMC6415318__F7 Schematic diagram of molecular mechanisms of Shuangyu Tiaozhi Granule (STG) attenuates hypercholesterolemia in rat fed HC diet ABCG8 ABCG5 LDLR HMGCR CYP7A1 ACAT2 PMC9204297__F3 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression NLRP3 TRPV4 TLR4 CS BDNF GSDMD CD36 PMC9204297__F2 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression NLRP3 NLRP1 LDLR AIM2 GSDMD PMC3059896__F2 Genetics and molecular pathology of Stargardt-like macular degeneration CFP ADAM18 RAX2 PMC4001025__F1 Vpr induces G2/M arrest through activation of the SLX4 complex PLK1 SLX4 CCNB1 EME1 CDC2 ATR PMC387762__F5 CREB pathway and possible positions of proteins whose genes contain CREB1 binding sites ARHGAP8 CABIN1 GRB2 PACSIN2 PMC8678610__F5 Lactic Acid Transport Mediated by Aquaporin-9: Implications on the Pathophysiology of Preeclampsia MPC1 MPC2 AQP9 PMC9253674__F7 Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1B Pathway by Nrf2 Signaling Activation MAF NLRP3 GCLM KEAP1 GCLC IL1B GSDMD PMC9256000__F3 Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung IL1A CFB EBP IL1RN HAVCR2 IFNG CXCL13 CXCL16 TLR7 CXCL9 CXCL17 CD300LF CCL22 PMC5912671__F2 Fanconi Anemia STAT1 ATM ATR IFNG PMC5912671__F1 Fanconi Anemia BLM RAD51 BRCA1 PMC4464398__F5 MAPK signaling pathway and neurotrophin signaling pathway maps CD14 BAD BRAF NGF ARHH MOS FLNA ATF2 SHE CDC25B NLK MAX RAE1 FRS2 GRB2 ECSIT BDNF JUN PMC8666374__F1 Schematic diagram showing common components and pathways driving cirrhosis-associated immune dysfunction and novel coronavirus-related disease CD14 IFNG PMC8839250__F10 Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5 NAPRT NAMPT HEL-S-90n NRK PMC8091792__F1 Pyroptosis: a new paradigm of cell death for fighting against cancer IL10 NLRP3 HMGB1 BAD IL18 NLRC4 NLRP1 IL13 GZMA AIM2 IL1B BAX PMC4595979__F1 LOX pathway CS DES PMC3672007__F2 Ingenuity pathways analysis canonical pathway IGF1 signaling This figure shows the IGF1 signaling pathway, with significantly upregulated genes in red, downregulated genes in green, and genes that did not meet our criteria for significance in gray OCEL1 BAD IGF1R IGF1 GRB10 JUN STAT3 PMC11911380__F2 Inflammatory crosstalk and anti-inflammatory mechanisms in the angiotensin II-induced fibrosis pathway RAC1 TNF PMC9480600__F5 Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy NLRP3 KEAP1 GCLC AIFM1 PGAM5 MTOR SIRT3 PMC8891295__F1 Opposing transcriptional programs ensure cholesterol homeostasis in macrophages ABCG1 LDLR ABCA1 PMC4133945__F1 Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention APC GSK3B DKK1 PMC8471303__F1 Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and Its Oral Supplementation Prevents Spontaneous Hepatoma GGA1 IPP PMC5731927__F6 Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway BCL2 BAX PMC5962057__F1 Monoclonal antibody targeting amyloid B (AB) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease HEL-S-62p C9 CFB C7 C6 RPE IL1B CFI PMC5414755__F1 Signaling pathway regulating the initiation of autophagy and the formation of autophagosomes ATG16L1 ATG12 AMBRA1 ATG101 PMC12112713__F2 Notch signaling pathway PINK1 DLL4 JAG2 FURIN DLL3 PMC7975703__F7 Proposed Schematic for AKR1B10 activating TLR4/NFKB signaling pathway by promoting FFA synthesis in NPC AKR1B10 TLR4 MYD88 PMC1988867__F7 Ingenuity pathway analysis showing regulatory relationships among differentially expressed transcripts TAF1 HSD3B1 FOS IGFBP5 GPX3 CCK NFKBIA LEP PLAT opn MT2A THBS1 SERPINB2 HEL-S-133P PMC10942021__F9 Crosstalk between mTOR and AMPK TSC2 TSC1 TRADD FOXO3A CDK2 INS ARHA ATP6V1D SKP2 PMC7239059__F5 SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing CNTRL TMPRSS2 PMC6864306__F5 Relevant signaling pathways deregulated in glioblastoma: receptor tyrosine kinase/PI3K/PTEN/AKT/mTOR pathway is shown in blue, CDKN2A/CDK4/6/ retinoblastoma is shown in green and p53/MDM2/p14ARF signaling pathway is shown in red PI3 LARGE CDKN2B EGFR MDM2 CDK4 PTEN MTOR CDKN2A CDK6 PMC5742740__F1 Hippo signalling pathway in Drosophila and mammals YAP1 LATS1 LATS2 PMC4623399__F6 Summary of protein and metabolites data at t = 8 h PDC MDH2 HEL-S-162eP PMC6251731__F6 Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells HEL-S-28 CDC37 PTEN EIF4E MTOR RHEB GDF15 ND1 MDM2 GRB2 CSA2 MCL1 RHOB PMC7335506__F2 Therapeutic targets on the interleukin‐1 pathway TRAF6 IL1R2 IL1R1 MYD88 IL1B PMC8375987__F3 Three visualizations of part of the “PKC-gamma calcium signaling pathway in ataxia” at WikiPathways (wikipathways:WP4760) ATP2B2 TRPC3 CACNA1A PMC8202022__F5 Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease IL10 FOS IL6 TIGIT MUC2 IL10RB HEL-S-102 CASP3 ITGAM COX2 IL18 TLR4 RELA JUNB NOS2 IFNGR1 IL1B PMC4011807__F1 Pathophysiology of anthrax illustrated as a series of steps ANTXR2 LRP6 FURIN ANTXR1 PMC2839261__F1 Effector pathways stimulated by Beta-ARs MAPK6 MAPK10 MAPK7 EGFR ST18 PMC3443208__F4 Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression EPOR BAMBI EPCAM MYLIP VASN POR LATS2 BMPR2 GALNT7 NPR3 CCND1 TNFSF12 NR3B3 KLHL20 KLF15 AIP KRT16 MAPK7 FGF16 AKTIP HSF2 CCNO ADPGK TNFAIP2 WDR37 EPHA2 NAPG PNP PMC9495176__F6 Bioinformatics and Genomic Analyses of the Suitability of Eight Riboswitches for Antibacterial Drug Targets HEL-S-182mP SHMT1 GLDC PHGDH GCSH PMC11529186__F6 Peripheral nerve injury exacerbated progression of muscle HO, caused by the release of NRG3, which induced osteogenic differentiation of FAPs via the ErbB4/PI3K/Akt signaling pathway NRG3 ERBB4 RUNX2 PMC7661519__F4 Gene pathway analysis of the co-expression and co-localization of mRNAs in this study HMGB1 LOXL2 RSAD2 CMPK2 BST2 FRMD3 MTOR IFI44 NF1 CRIP2 RNF144A HEL-S-301 ABHD8 SLC27A1 HEL-S-304 MVB12A SCA7 MIB2 ARMC9 PMC9207209__F3 Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism HEL-S-26 COX1 PGM2 ACO2 CYC1 ENO1 ENO2 HEL60 COX5A HAP1 HEL-S-68p PMC3713775__F2 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response ATM BRCA2 MDC1 RAD50 RAD52 RAD51 ATR H2AX MRE11A BRCA1 PMC3713775__F1 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response NRF ATM EZH2 SUZ12 PMC8508046__F3 Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas PIK3R1 MAML1 RNF43 BRAF DKFZp781B1423 SKP1 RB1 PIK3R3 FBXW7 SMARCC2 NF1 CREBBP KMT2A SMARCA4 EP300 ATM RPS27A MSH6 MDM2 PIK3CA MSH2 PIK3R2 PMC11823264__F4 JNK signaling pathway TRADD MMP9 CDC42 PMC6864436__F7 The schematic diagram of ICA activation of BMP2–induced osteoblast differentiation in C2C12 cells RUNX2 BMP2 SMAD1 DKFZp781O1323 SMAD9 PMC10879531__F6 Mechanism of action of Gal-3 in the A-ED through the TLR4/MyD88/NFKB pathway TLR4 MYD88 TNF PMC4818970__F3 Growth factor signaling pathway TSC2 TSC1 MYC MDM2 PTEN RHEB PMC8874510__F1 Structural View of miRNA Biogenesis and Function AGO2 DGCR8 DROSHA PMC7272522__F2 Antioxidant and detoxifying processes involved in genoprotective activities AHR KEAP1 HEL-S-44 PMC5870609__F5 Differential network of cancer pathway between BRCA tumor samples and controls CTBP2 EGF GNG7 TGFBR2 PTEN CDKN2A FGFR2 COA3 PDGFA GNG2 ZBTB16 CASP9 HDAC2 MSH2 BMP2 RXRG CEBPA LAMA3 IKBKB DAPK2 EDNRA EGLN3 EDNRB ERBB2 PIK3CA CXCL12 VEGFB ARNT2 AKT3 PMC4026869__F6 Gene network of 32 genes with pathway level expression change and mutation via GeneMANIA HEL70 BRAF MAP2K4 EGFR EZR HRAS MTBP COL17A1 TSC2 IKBKB RPL11 MDM2 GRB2 THBS1 EHHADH SKP2 AKT3 APPL1 PMC2831005__F10 Yeast cell cycle CDC20 FAR1 APC CLN3 PMC3940872__F7 Synthetic Alpha-Bromo-2′,3,4,4′-Tetramethoxychalcone (Alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway JUNB OSM PMC6129988__F1 Current pathogenic model of psoriasis STAT1 CXCL1 PDC CCR6 CXCL10 CCL20 LCN2 CXCL9 CD83 CXCL11 STAT3 PMC3199787__F4 Graphical representation of the IL-6 signaling pathway reveals significant gene expression changes following sarin-induced seizure A2M LBP UNK TRAF2 JUN PMC3923671__F1 Impairment of T Cell Function in Parasitic Infections BAX PMC8097256__F1 Human cell receptors: potential drug targets to combat COVID-19 DPP4 BACE2 MSC FURIN ACE2 TMPRSS2 PMC2626169__F1 A simplified view of the sex-determination pathway in XX animals (A) and XO animals (B) SDC1 SDC2 HTRA2 SDC3 PMC7319585__F2 Molecular steps of FEME carrier formation PI3 BIN1 GSK3B CDK5 SH3BP1 OPHN1 CDC42 PMC4314372__F1 Biology of Castrate Resistant Prostate Cancer ERG SMAD2 MYC SMAD4 SRC PTEN EZH2 MTOR CYP17A1 SOX9 SOX4 PMC4785274__F1 H2S biosynthesis, functions, and metabolism PMC6085621__F7 Gold nanoparticles and Wnt/Beta-catenin signaling pathway APC MYC LRP5 CCND1 LRP6 PMC2837947__F2 Disruption of metabolic pathways involved in fat pad mass trait in mouse models of the candidate genes ME1 GPX3 LACTB GAS7 LPL TGFBR2 ZFP90 TG C3AR1 PMC9170767__F1 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks LYPLA1 LPCAT3 HAL MAOA CNDP1 CNDP2 HDC DDC CEPT1 GPCPD1 PLA2G4E UROC1 FTCD PISD PEMT PLA2G4B ALDH1A3 PNPLA6 PLA2G5 PLA2G2D PLA2G4C CARNMT1 PLA2G2F PLA2G4F PLA2G12B ALDH3A1 PLA2G10 ALDH2 PMC7471649__F6 Protein-protein interaction analysis by STRING TGFB1 PMC9170767__F3 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks MGA PMC11045904__F3 Intricate relationship between the gut and brain axes in PD is delineated by the schematic signaling pathway, with a focus on the inflammatory cascade triggered by dysbiosis at the gut lumen and BBB TH TLR4 PMC2846056__F3 Making the blastocyst: lessons from the mouse CDX2 TEAD4 LATS1 LATS2 PMC11045904__F2 Inflammatory signaling pathway involved in AD is depicted in the figure NLRP3 APP TNF IL1B PMC9277163__F11 Protective Effects of Cinnamaldehyde on the Oxidative Stress, Inflammatory Response, and Apoptosis in the Hepatocytes of Salmonella Gallinarum-Challenged Young Chicks TSC2 TSC1 GSK3B MTOR PMC4947689__F1 Hcy metabolism HEL-S-61p PMC6678355__F5 Unigenes involved in the Wnt signaling pathway: Red and green represent upregulated and downregulated genes, respectively BAMBI ROCK2 NLK DAAM1 SIAH1 APC SOST CER1 SMAD4 SKP1 ARHA POR PMC3051184__F9 Proposed model explaining upregulation of CREB expression by RA in NHTBE cells SP2 SP1 PMC6414239__F1 Metabolic perturbations in classic galactosemia beyond the Leloir pathway: insights from an untargeted metabolomic study PMC8027222__F6 Mating type specific transcriptomic response to sex inducing pheromone in the pennate diatom Seminavis robusta MYB OCEL1 CDC20 ATM TOMT GC RAD51 MRE11A PMC5222372__F1 Overproduction of Alpha-Lipoic Acid by Gene Manipulated Escherichia coli LIPA APOD PMC4659438__F4 Molecular pathogenesis and potential treatments for thrombotic microangiopathy in the glomerular endothelium HEL-S-62p VCAM1 APC VWF TNF TF PMC6054450__F3 Merkel cell carcinoma NOTCH2 RB1 MTOR BRCA1 ARID1A KMT2C ARID1B BCOR MCC KMT2A SMARCA4 ATM BRCA2 ASXL1 NOTCH1 MSH2 MLL2 PMC7758635__F7 Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development BOC PTCH1 SMO PMC7746424__F2 Immunomodulation and cell apoptosis induced by the dopamine pathway HEL-S-101 GSK3B DRD1 DRD2 STAT3 PMC3109102__F1 Basic intracellular molecular pathways regulating MN survival during development CASP3 APAF1 MDM2 CASP9 PTEN MTOR CASP8 PMC6306858__F1 Primer of the inflammatory cascade TH IL16 MYD88 CSA2 IL1B PMC5595802__F1 Melanoma (Skin) tumorigenesis pathway, collected from KEGG BAD BRAF CCND1 CDK4 PTEN PMC5524810__F1 Angiotensin II signaling pathway underlying vascular aging MMP2 MMP9 PMC8962104__F2 Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications AQP1 ROCK1 ATF4 MYOC OPTN BDNF XBP1 TMCO1 PMC4349622__F3 Schematic diagram showing the multi-regulation loops of LRRC4/NGL-2, miRNAs, TFs and target genes in glioma LRRC4 E2F6 MYC ARHA BRD7 SP1 PMC4349622__F2 Schematic diagram showing the signaling regulation network of LRRC4/NGL-2 in glioma CDK2 CXCR4 CCND1 CDK4 STAT3 PMC5610024__F4 The dual role and therapeutic potential of high-mobility group box 1 in cancer HMGB1 TLR4 PMC1304643__F2 Probability flux distributions for human red blood cell ADA KIN HEL107 HEL-S-162eP PMC7815415__F5 PPAR signaling pathway of potential targets of allicin UBC PLTP HEL-S-28 LPL PMC11611192__F8 The signaling pathway by which high glucose participates in the GEnCs injury via the RXRA/circ8411/miR-23a-5p/ABCA1 pathway ABCA1 GSDMD RXRA PMC3960371__F4 Autophagy Paradox and Ceramide LASS1 BNIP3 MTOR BAX PMC5658785__F4 Roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease MMP2 S100B IL1B PMC8159759__F1 Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases NLRP3 TLR4 NOD1 SRA1 NOD2 CD36 PMC5343846__F2 Effects of the loss of cell division cycle 73 (CDC73)/parafibromin on epigenetic regulatory mechanisms in PCas RNF20 EZH2 CDC73 PMC5343846__F1 Wnt/Beta-catenin pathway is potentially deregulated in PCas APC LRP6 DKK1 WT1 AXIN2 HIC1 CDC73 PMC5975105__F1 Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins OSBPL6 NPC1 ABCG1 LDLR ABCA1 NPC2 OSBPL9 HMGCR PMC8350729__F2 Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications CCND1 BCL2 PARP1 SMO HIF1A MTOR JUN STAT3 BAX PMC9364366__F1 Key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance DES CERK SMS PMC6428898__F3 Mec1/Rad53 pathway senses ongoing DNA replication to inhibit mitotic entry MRC1 PPIE RET PNMT PPL SOST DBF4 PMC8669377__F2 Targeting the “sweet spot” in septic shock – A perspective on the endothelial glycocalyx regulating proteins Heparanase-1 and -2 CD14 TFPI BDNF PMC7181071__F1 Main pathway for autophagy modulation ULK1 TFEB ATG12 ATG3 ATG101 UVRAG ATG10 DKFZp686F0183 PMC7935919__F3 Schematic illustration showing altered coagulation pathway proteins in polycystic ovary syndrome (PCOS) TFPI PLG FDPS VWF TF PMC9146244__F2 Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System NGF BDNF PMC7903350__F6 Compound-target network of EIF PIK3R1 EGF IGF1R EGFR GSK3B INS TAC3 BCL2L1 PTEN MTOR GNAI1 INSR KDR ATM GNG2 PTPN1 PTK2B KISS1 MDM2 SRC TACR3 CYP1A1 HEL114 NCOA1 CYP17A1 GNRH1 FOXO3A VEGFA TACR2 IRS1 GHRH CREBBP EP300 PELP1 MAP2K1 CDKN1A PRLR GRB2 PPP2CA PIK3CA GNAS SOS1 PMC7903350__F5 Pathways related to hypothalamic-pituitary-gonads axis and targets of EIF BMP6 EGR1 MMP2 BMP15 LDLR HBEGF FSHR RAF1 CDC42 INSR PMC7412063__F4 Interactions between network molecules and DNA damage checkpoint pathways OAF PLK1 ATM PLA2G2E PGLYRP1 ACAN CP PMC5940270__F2 CGAS–cGAMP–STING pathway detects cytoplasmic DNA after DNA damage and activate type I IFNs and other cytokines TBK1 CGAS TREX1 IRF3 PMC6096065__F7 Protein-protein interaction network of predicted target genes of hsa-miR-203 SPARC CUTA ADA CP PMC6096065__F6 Protein-protein interaction network of predicted target genes of hsa-miR-1 LRCH2 AMOT SHANK2 RIT2 RARB INMT ANKRD29 PTPRG STEAP2 RYBP SMYD4 MMD IMPACT UST ABI2 MON2 MCAT TAGLN LRAT PUM2 ZNF43 NOTO ZNF14 PCDHB3 CTNNA2 PMC4963809__F2 Schematic illustration of the canonical Wnt signal transduction cascade APC GSK3B LRP5 LRP6 PMC8227153__F4 Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients? RNASEL ISG15 IFIT2 OAS3 IRF7 IFNAR2 MYD88 IFNAR1 IRF-1 TLR3 TICAM1 IFIT1 PMC3236209__F6 Transcriptome Analysis of H2O2-Treated Wheat Seedlings Reveals a H2O2-Responsive Fatty Acid Desaturase Gene Participating in Powdery Mildew Resistance MYB ERF HEL-S-5 PMC5794417__F8 Schematic diagram on regulation of PCSK9 on apoB via modulating the autophagy pathway affecting atherogenesis PCSK9 ULK1 APOB MTOR ATG14 DKFZp686F0183 PMC7255975__F2 Hypothetical mechanism by SARS-CoV-2 in establishing an inflammatory feedback loop between IL-6 and angiotensin II ACE2 ADAM17 PMC8888908__F1 Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease) ULK1 ATG12 ATG3 LCK UVRAG ATG10 ATG14 DKFZp686F0183 PMC5731853__F7 Let-7g suppresses both canonical and non-canonical NFKB pathways in macrophages leading to anti-atherosclerosis IL16 RELA SREBF2 RELB ABCA1 BAX PMC3465517__F5 Network analysis of proteins found to be significantly altered in abundance in the CSF proteome by ANOVA (p value <0.05) following analysis of individual subject samples PROS1 FBLN2 CNTN1 SERPINA3 ORM1 CLU APLP1 A2M CFD CFH HEL-S-2 opn APP HEL-S-44 RBP4 SERPING1 SERPINA1 SCG2 CHGB GM2A SCG5 HRG CFB IGSF8 IGF2 CD44 SPARCL1 HEL-S-130P BCAN THY1 HSPG2 ADAM22 HP ORM2 IGFBP6 CSF1 SERPINF2 CP TF PMC9367204__F1 Of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis PI3 PIKFYVE ACE2 ORAI1 STIM1 TMPRSS2 PMC5890336__F1 Canonical PI3K/AKT/mTOR signaling pathway TSC2 TSC1 ERBB2 ERBB3 PTEN EIF4E DEPTOR IRS1 RHEB PMC3077214__F1 Signaling pathway components used to test gene–compound interactions SPR EGF SMO PTEN JUN PMC5582926__F9 Schematic description of EET-mediated perturbations in the Wnt1-NOV-PGC-1Alpha-HO-1 pathway in cardiac and adipose tissue of db/db mice WNT1 IL6 IL1B PMC7302136__F9 LncRNA LINC00314/miR-129-5p/GRM5 in osteogenic differentiation of ADSCs PMC8210162__F11 Novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells DKFZp781B1423 MDM2 TRIM28 SRSF10 PMC10758056__F8 NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway TOPBP1 ATRIP CDC2 ATR PMC10742465__F7 The proposed cardioprotective mechanism of hydrogen after CIH exposure KEAP1 FES FBXL5 PMC2881280__F1 Schematic representation of the proposed enzymatic steps in the FAC -elicited JA biosynthesis pathway regulated by SIPK, WIPK and NPR1 GLA PMC4586799__F4A The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis DHH IHH SUFU GSK3B ENO1 SMO PMC3975884__F1 EGFR associated signaling pathways in lung cancer EGF EGFR SRC MTOR RHEB PMC9603893__F3 Integrin Alpha v Beta 6 (AvB6) and Its Implications in Cancer Treatment VTN RAC1 PMC84608__F12 The central role of the E2F transcription factors in cell proliferation and apoptosis CDC6 PIGS PMC5998975__F8 Proposed crosstalk pathway between A2AR signaling and Semas SEMA4D SEMA3A ERBB2 ARHA PMC11123779__F5 Protein–protein gene network in RA-infected ducks HBE1 IRAK2 NFKBIZ PTGER3 CCL2 LAG3 SCRG1 TNFRSF11A USP18 MMP2 FAM13A CCL19 NOS2 MMP10 RSAD2 IRF7 IRF9 ATF3 NGL1 CCL4 PTPN13 TNF ACKR4 GGT7 CREM CD36 PGR IFNGR2 CEBPB CCL17 APP CXCL6 BST1 PCBD1 IL10 PLB1 IL13RA2 OTC TNFRSF11B BIRC2 NFKBIA CISH SDC4 KIF17 ZC3H12A MME ENTPD4 NCF2 NTNG2 PMC7204509__F4 EP remodels purine and arginine metabolism, glutathione homeostasis, and the Krebs cycle in BMDMs CIT MAL PMC6676405__F2 Putative Cripto-1 targets the MAPK, FA and ErbB signalling pathways FGFR1 SRC BCL2 CRK PXN PMC9241025__F3 Gene Regulatory Circuits in Innate and Adaptive Immune Cells TH RORC RBPJ STAT4 IL33 IKZF3 GATA3 STAT3 PMC10342783__F9 Phenylalanine metabolism (a) and neuroactive ligand-receptor interaction (b) KEGG pathway MLNR HEL-S-62p PTGFR UTS2R APLN GRPR TAC3 CALCR LPA VIP MLN NPY GHR TACR3 LEPR TRHR GAL HCRT GNRHR GHSR SST SCT GIPR PMCH NTS PTH SCTR LHB LTB4R TACR2 GHRH NMU CCK LEP GHRL TSHR CRH OXTR TRH PRLR UTS2 AVP OXT FSHR NPFF PMC6566886__F4 Adiponectin-induced signaling pathway TSC2 ADIPOR1 ADIPOR2 PTEN MTOR IRS1 STAT3 BAX APPL1 PMC6566886__F3 Leptin-induced signaling pathway COX2 AIP GSK3B GRB2 CCND1 IRS1 EXOG STAT3 PMC9180116__F4 O-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology GNE PDC NAGK CS OGA OGT FH IRS1 RPE GALP PMC10603888__F10 Signal path analysis: (A) thyroid hormone synthesis (Calcium ions within the cell are transported outside the cell via the transmembrane, as indicated by the red boxes TH TTF2 HEL111 DAO TSHR DUOX2 HEL-75 TPO TG PMC7707960__F2 Putative schematic of the Rac1 signaling pathways involved in different neurodevelopmental disorders ERBB4 AUTS2 HTT SHANK3 ELMO2 NRG1 RAC1 BDNF PMC7707960__F1 Regulation and interaction of Rac1-related signaling pathways at the postsynaptic terminal CDKL5 AUTS2 SHANK3 ELMO2 RAC1 BDNF PMC7218999__F7 Protein-protein interaction analysis based on STRING with an interaction confidence score (0.400) COX2 GLO1 NCL HEL-S-30 PDK2 SUCLG1 PURB MCCC1 AKR1B1 RPS3 HEL107 SUMO1 PMC8440935__F4 Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients HEL-S-62p MTAP MTR TPH1 DDC HOXA4 HLA-F PMC4945713__F3 Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease TH ChAT NGF LIF PMC8263651__F8 Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3B/Beta-catenin signaling pathway APC GSK3B LRP5 CCND1 LRP6 PMC4821805__F1 Evolution of haem biosynthetic and degradative pathways FECH UROD UROS HMBS CPOX PMC7883771__F3 RA signaling and OFCs CYP26A1 CYP26B1 RERE TBX1 ALDH1A3 SHH LRP6 CP PMC5142116__F1 Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy HEL-S-302 DBP TEF HLF PNP PMC9582522__F3 Brain-gut-muscle axis in human health and energy homeostasis SOCS2 AHR IFNAR1 VEGFB TGFA PMC9582522__F2 Brain-gut-muscle axis in human health and energy homeostasis NPY IRAK1 AgRP IRAK2 FGF19 PMC5503659__F1 Roles of long noncoding RNAs in colorectal cancer metastasis BAX PMC4885862__F4 Survival strategies used by E TLR4 CAP1 COPA FURIN ADAM17 NEDD4 PMC4885862__F3 Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy ARID1B DAZAP2 LRP6 PORCN ARHA RAC1 IRF2BP2 KDM6B FZD5 VPS29 PMC5728441__F1 Found in translation: how preclinical research is guiding the clinical development of the BCL-2-selective inhibitor venetoclax BAD BIK HRK BAX PMC5503659__F3 Roles of long noncoding RNAs in colorectal cancer metastasis RAB22A MYC CD44 BCL2 TCF7L2 EIF4A3 PTEN PMC3684061__F4 Genetic Risk Factors for Pancreatic Disorders PRSS1 CASR CTRC SPINK1 CLDN2 CFTR PMC9279633__F1 Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles ULK1 ATG12 ATG3 NRBF2 ULK2 MTOR SNAP29 DKFZp686F0183 TFEB APP PICALM UVRAG STX17 ATG14 GABARAP PMC3109860__F4 CHK1 Inhibitors in Combination Chemotherapy ATM SRC PARP1 ATR BAX PMC8007787__F1 Reverse transsulfuration pathway and inputs from associated pathways HEL-S-61p VIT PMC4383754__F1 Cholesterol synthesis and metabolism in the brain NPC1 DHCR7 DHCR24 HMGCR PMC8268312__F3 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators STAT1 STAT2 IRF3 TYK2 JAK1 MAVS PMC9173833__F6 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 IL13 IL6 TNF IRF-1 PMC8268312__F1 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators TLR8 TLR7 IRF3 MYD88 ACE2 MAVS TMPRSS2 PMC2939656__F4 Complement/Coagulation pathway activation F10 PROS1 C4B_2 F2R THBD F8 F9 PROC C4A CR1 PLAT C9 A2M F2 F3 C7 VWF F11 PLAUR PLG KLKB1 C3AR1 CPB2 CD59 F5 C6 F7 CR2 PMC9372463__F2 Influence of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction IGF1 SIRT1 SIRT3 PMC3563405__F1 represents the melanin synthesis in human, plants, fungi and bacteria starting from tyrosine whereas; (B & C) shows melanogenesis from secondary metabolites in fungi and bacteria respectively SCD DCT TYRP1 PMC6329659__F4 Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair DISC1 ATM GSK3B H2AX PMC7273800__F3 Gene–gene networks generated by pathway analysis from the 17-gene set TMOD1 SHANK3 STAB2 TNFRSF11B INPP4B CYP2A6 LCOR CLEC11A TCF2 IAPP FOXA2 BAZ1A TNFSF11 CLEC4A ABCG1 PACSIN2 UNC119 ABCB1 ACKR2 ERAF PMC11856986__F6 Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology BAD HGF BRAF EGFR GRB2 SHE PIK3CA PTEN AXL TGFA STAT3 BAX PMC6039250__F5 NRF2 and the hallmarks of cancer ME1 GCLM GCLC SHMT1 PSPH HEL-S-51e HEL107 MTHFD2 TXN UCP3 FASN GLS PMC7923894__F2 Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease TLR4 GC AQP4 PMC8897867__F1 Activation of cryptic xylose metabolism by a transcriptional activator Znf1 boosts up xylitol production in the engineered Saccharomyces cerevisiae lacking xylose suppressor BUD21 gene FBP1 ENO1 ZNF14 MAL PMC7920504__F4 Candidate genes for osimertinib resistance presented within cancer-related signal pathway EGF NRG3 BAD NRG2 MYC SHE HBEGF NRG1 MTOR CRK BTC GRB2 TGFA NRG4 JUN PMC6039250__F2 NRF2 and the hallmarks of cancer KEAP1 GSK3B GSK3A SKP1 RBX1 PMC7888496__F4 Proposed model of the role of the JAK-STAT signaling pathway in the development of FLHS in chickens CNTF SOCS3 PTPN1 IL6 STAT3 PMC8584061__F4 Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure? PIK3R1 RIT1 IGF1R BRAF ALK EGFR FGFR4 PTEN FGFR2 NF1 ERBB4 FGFR1 PTPN11 MAPK1 ARAF ROS1 NTRK2 KIT PDGFRA ERBB3 NTRK1 FGFR3 RAC1 HRAS CBL RET MAP2K1 ERBB2 PIK3CA FLT3 SOS1 PMC3270095__F4 Regulatory network for PACAP-responsive genes HEL-S-102 FOS ATF4 KLF4 BTG2 PMC5890889__F4 Proposed ferritin-mediated feed-forward inflammatory loop TLR9 CD163 HMOX1 PMC4910120__F4 Therapeutics in development target the IFN pathway in SLE PDC TLR7 TLR9 TYK2 MYD88 JAK1 DNASE1 PMC4910120__F3 Overlapping type I, II and III IFN signaling pathways STAT1 STAT2 IFNK TYK2 JAK1 IFNG PMC9686445__F9 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations CCR3 CCL26 PMC9686445__F6 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations NGF CRH IL6 PMC4397892__F2 Inhibition of the classical apoptosis and autophagy pathway by Gamma-herpesvirus proteins UVRAG PMC6683665__F5 Interplay between shrimp NFKB pathways and WSSV TRAF6 MYD88 PMC8771831__F3 Melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease GSK3B IRS1 PMC6683665__F4 Comparison of the shrimp IMD pathways (A) and Drosophila IMD pathways (B) and Human TNFR signaling (C) TRADD FADD TAB3 PMC6683665__F3 Positive and negative regulatory events in shrimp Toll pathways TRAF6 MYD88 PMC12090863__F1 Paclitaxel, interferons and functional reprogramming of tumor-associated macrophages in optimized chemo-immunotherapy CXCR3 HMGB1 CCR5 CXCR1 TLR4 CXCL10 CXCR4 CXCL9 CCL5 CXCL11 IFNG PMC6097677__F1 Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition PERP TOPBP1 PCNA PMC11065698__F1 5-LO-dependent oxylipin formation from ARA, EPA and DHA MGST2 LTB LTC4S PMC3999940__F3 Case study of the RegPhos-discovered phosphorylation networks involved in BCR signaling pathway BTK CDS1 BCL10 BCR BASH CD2 CD22 LYN GRB2 SYK CD19 CBL PMC3177754__F4 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity CARD9 BCL10 IRF3 IL1B NOD2 PMC6038340__F8 Intra-pathway feedbacks and BRAF/MEK growth-inhibitory synergism BRAF EGFR PMC7377942__F7 Mechanism of metformin‐mediated improvement of mouse oocyte apoptosis defects induced by arecoline HEL-S-2a CASP3 GPX1 CASP9 HEL-S-44 HEL-S-128m BAX PMC9113573__F6 Proposed mechanism by which proHp inhibits the TGF-Beta-induced EMT in SK-Hep1 liver cancer cells SMAD2 CDH2 SMAD1 DKFZp781O1323 PMC10031043__F1 Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex CIAO3 CIAO2B ABCB7 CISD2 RTEL1 CIAO1 CISD1 NTHL1 PRIM2 NDOR1 POLE MMS19 MUTYH DNA2 PMC11560026__F11 Mechanism by which SH3KBP1 impairs PRRSV replication, created in BioRender TBK1 IRF3 TRIM25 MAVS PMC7604490__F2 Genetic pathways implicated in vascular anomalies GNA11 NF1 KIT BRAF GNA14 ENG PTEN MTOR PMC1288263__F2 Mammalian sex determination: a molecular view SF1 WT1 SOX9 SRY PMC3764474__F1 SIRT1-dependent deacetylation of substrate proteins NAMPT NMNAT1 NMNAT2 NMNAT3 SIRT1 PMC7600400__F2 Reactive oxygen species (ROS) removal and effects HEL-S-44 NNT PRX PMC5390489__F5 Metabolic switch between MEP and MEC PDC DAP HEL-S-162eP PMC3290818__F1 TLR signalling pathway TLR4 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR3 TIRAP PMC6636231__F2 Proposed working model of RGS proteins in the regulation of the Ca2+ oscillation-NFATc1 signal pathway for osteoclast (OC) differentiation NFATC1 OSCAR RGS12 RGS10 SIRPB1 PMC11889778__F1 NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium PTCH1 SHH SMO PMC9274608__F3 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers MAP2K4 SERTAD3 PMC6332435__F1 An overview of cellular endocytic mechanisms ARHA ARF6 ARF1 CDC42 PMC9274608__F2 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers OTX1 PBX3 PMC8198078__F2 Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of Beta-Amyloid Protein and Phosphorylated Tau TRPC1 RYR3 RYR2 ORAI1 STIM1 PMC9369367__F1 Harnessing the Power of Purple Sweet Potato Color and Myo-Inositol to Treat Classic Galactosemia ATF4 EIF2A HEL-S-19 PMC3351834__F2 Transcriptional changes in TGFB1 signaling pathway E2F4 ID4 LEFTY2 MAPK3 SMAD2 MYC SMAD4 TFDP1 IFNG DCN BMPR2 ACVR2B ACVR2A BMP5 BMP8B ROCK2 INHBC BMP6 ZFYVE9 E2F5 TNF RBX1 THBS4 THBS2 THBS3 RPS6KB2 SMURF2 PPP2CA COMP TGFB1 NODAL TGFBR1 TGFBR2 BMP4 FST NOG AMH BMP8A ZFYVE16 THBS1 GDF6 gdf7 PITX2 BMP2 SMAD6 AMHR2 SKP1 BMP7 ARHA ID3 SMAD9 RPS6KB1 GIG8 EP300 INHBB INHBA INHBE PMC8905584__F7 To detect potential pathways and target genes in infantile Pompe patients using computational analysis ROCK2 BAMBI INVS STOM APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA NLK SIAH1 PMC8496196__F9 CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner EPHX1 CDK14 CDC42 PMC7323084__F4 Rationale for targeting complement in COVID‐19 HEL-S-62p C5AR1 ACE2 PMC8047423__F1 Complex regulation of HSC – and possibly hibernators – cell cycle entry ULK1 FOXO3A CDK2 CDK4 PTEN JUNB MTOR CDK6 HES1 PMC8465370__F5 Insights into Alexandrium minutum Nutrient Acquisition, Metabolism and Saxitoxin Biosynthesis through Comprehensive Transcriptome Survey OTC CIT AMT ASL CP PMC3177754__F3 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity IRF3 TRIM25 PMC6269465__F1 Effect of SPPL2a deficiency on IFNG machinery SPPL2A APC PMC6475670__F5 Tumor necrosis factorA signaling in gastric cancer TRADD TRAF1 TNF TRAF2 FADD PMC4043736__F3 Patterns of Gene Expression Associated with Pten Deficiency in the Developing Inner Ear PVALB TU3A ESPN GAL PMC7870860__F1 Central role of self-nucleic acids in obesity-mediated metaflammation NLRP3 HMGB1 CGAS TLR7 TLR9 IRF7 IRF3 IL6 MYD88 AIM2 TLR3 PMC7926708__F8 Brief overview of the autophagy pathway, which is a catabolic process that includes a specific intracellular cargo, such as organelles or endosomal contents that are intended for degradation ULK1 ATG16L1 ATG3 PIK3R4 PMC8895457__F7 Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma MYC BCL2 BAX PMC6475670__F4 Interaction network showing miRNAs and their predicted and validated targets CASP3 TRADD NFKB2 NFKB1 TNF TRAF2 CASP8 PMC5377794__F6 Diagrams demonstrating the processing of Okazaki fragments FEN1 POLE DNA2 PMC9285942__F1 WNT/B‐catenin dependent transcription: A tissue‐specific business APC GSK3B PMC7886502__F1 Regulatory effects of the estrogen-BDNF-mTORC1 signaling pathway in depression CORT CRH BDNF PMC3588029__F3 Regulation of PGC-1A—this schematic represents the relationship between nutrition, circadian clock and other regulatory factors involved in post-translational modification of PGC-1A and its consequent impact on metabolic genes and aging NAMPT GSK3B YY1 SIRT1 PMC8511346__F1 Sleep and Diet: Mounting Evidence of a Cyclical Relationship TPH1 TPH2 AANAT PMC3790664__F1 Comparing feedback mechanisms in morphogen signaling EGF DHRS3 PMC6980728__F3 NAD+ biosynthetic pathways and model for SARM1-mediated degeneration NAPRT NAMPT NMNAT1 NMNAT2 NNMT NMNAT3 SARM1 NRK PMC8320431__F1 Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis SMAD2 S1PR1 IL8RB ADRBK1 PMC3138532__F1 HNSCC tumor microenvironment EGF IGF1R EGFR GRB2 SRC MTOR STAT3 PMC2194763__F5 Cell cycle pathway diagram obtained from GenMAPP (Gene Map Annotator and Pathway Profiler, Gladstone Institutes, University of San Francisco, San Francisco, CA [38] CCNA2 PLK1 GSK3B CCNH SMAD4 RB1 TFDP1 PKMYT1 CCND2 CCNE1 CHEK2 MAD2L2 ATM TBC1D8 CCNB1 PRKDC YWHAG PTTG1 RBL1 CCNE2 UBE2F MAD2L1 CDKN1B CDC25B CHEK1 CCNB3 CDC20 EP300 CDC6 BUB1B CDK2 CCNB2 ATR MPEG1 TGFB1 PCNA SKP2 ESPL1 PMC7155752__F3 Signal transduction in the early Drosophila follicle stem cell lineage SUFU RAB23 SMO PMC7155752__F2 Signal transduction in the early Drosophila follicle stem cell lineage MMP2 APC EGFR PMC8306262__F4 Statins: a repurposed drug to fight cancer GPX4 IPP PMC8306262__F3 Statins: a repurposed drug to fight cancer LDLR RHO IPP HMGCR PMC4573392__F1 Emerging concepts in the regulation of hematopoiesis by inflammatory signaling EPO MSC IFNG STAT3 PMC8122924__F2 Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer IGF1R IGF1 ARHA IRS1 TF PMC9445272__F8 CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3B/Beta-catenin pathway GSK3B CCND1 CDK9 PMC7242365__F4 GWSS host support of nutritional metabolisms in Sulcia-GWSS and Baumannia VIT PPCS PPCDC COASY PAH THRA GADL1 PMC8635159__F3 An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease OGA GNPNAT1 PMC5479992__F1 Iron homeostasis HAMP FES HFE TFR2 PMC7663173__F5 YZT-mediated network analysis reveals UPS as potential target HYDIN IKBKE USP2 ATP6V0C USP28 MARK1 TACR1 NEDD8 IL12A RDX UBB HMOX1 UBC RIPK1 CELF1 REST KRT14 PMC7058704__F2 Autophagy regulation under various stresses TAF1 ATG3 NBR1 HEL-S-162eP PMC3926866__F1 Diagram of the steroid hormone biosynthetic pathway in the human adrenal cortex CYP11A1 HSD3B2 CYP17A1 CYP21A2 CYP11B2 PMC7058704__F1 Autophagy process ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 PMC8348198__F3A R-loop modulated epigenetic regulation in T helper cells mechanistically associates coronary artery disease and non-small cell lung cancer CCR5 CCR2 CXCL5 MAPK3 CXCL8 CXCL3 CCL7 CCL5 CCL2 CCR8 CCL1 PDPK1 CCL16 IL16 CCL24 CCL13 MAPK1 IL17C B2M CSF2 IL10RA NAMPT CCL8 IL1A CCL26 BAK1 CXCL10 IL1RN VEGFA IL8RB TNF IL10RB IL15 RASSF1 CCL20 GRB2 BCL2 CXCL12 TGFA CXCL1 EGF IL5RA IGF1R CCR3 BRAF CS CX3CR1 CSF3 EGFR IL17F IL1R1 IL17A CD40LG IL1B RPLP0 CCL11 IL13 BMP2 CCR4 CXCL2 MAP2K2 TNLG2B IL5 TNLG7A HEL-S-162eP CCL15 IL27 TNFSF10 IL33 PIK3CA IL-21 SOS1 CCL23 CSF1 OSM CCL3 PMC8877168__F4 The NFKB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV TH REN NFKB2 TRAF1 PTGS2 CCL4 TNF IL1B PMC8408990__F2 Transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes SCIMP APOO APOC2 APOC1 APOC4 NECTIN2 CD2AP PVRIG CLU PMC3391249__F8 Defence Signalling Triggered by Flg22 and Harpin Is Integrated into a Different Stilbene Output in Vitis Cells HP MSC FLG PMC5335504__F9 Proposed model for the role of ADAP2 in antiviral response TBK1 TRAF3 IRF3 CENTA2 MAVS PMC8172903__F1 STING1 network regulates autophagy and cell death CGAS MITA NFKB1 IRF3 PMC6436758__F7 Cellular response to small molecules that selectively stall protein synthesis by the ribosome PELO ZNF622 ASCC2 NEMF EIF6 ASCC1 LTN1 HBS1L PMC8172903__F3 STING1 network regulates autophagy and cell death TBK1 CGAS BAK1 RIPK3 IRF3 BCL2L1 TNF CASP3 APAF1 NFKB1 CASP9 CASP8 FADD MLKL CYCS BAX PMC8172903__F2 STING1 network regulates autophagy and cell death TBK1 ULK1 MITA SQSTM1 WIPI2 MTOR DKFZp686F0183 PMC11854789__F1 Mechanism and Applications of Vagus Nerve Stimulation TNF GDF11 BDNF STAT3 BAX PMC4658161__F7 Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NFKB Signaling EYA1 EYA2 RNF31 SHARPIN PTEN PMC2722148__F1 MAPK transduction signaling pathway MAP3K1 GRB2 FGFR2 PMC3814597__F2 General activation of interferonB (IFNB) transcription and induction of IFN-stimulated genes STAT1 STAT2 IRF9 IRF3 TYK2 JAK1 PMC8306508__F5 Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28null T Lymphocytes in Rheumatoid Arthritis Disease VASP F2R ARHH APC F3 ARHA ABI2 HEL114 RAC1 LPA THY1 CDC42 PMC7060471__F2 Pharmacological manipulation of the activity of Wnt/B‐catenin signaling pathway APC PORCN TNKS PMC7060471__F1 A, Position frequency matrix of the T‐cell factor (TCF) motif was obtained from the JASPAR database (http://jaspar.genereg.net) HAL TF PMC3824408__F1 Unveiling the last missing link of the cardiolipin synthetic pathway in mitochondria PGS1 CDS1 PGP ART5 PMC5088199__F1 Cellular pathways currently being targeted in the treatment of endometrial cancer (EC) and the potential actionable genes in EC identified via Next Generation Sequencing (NGS) POLD4 POLD2 BAD PPP2R1A PTEN FBXW7 ARID1A POLD3 RXRA POLE2 POLE4 POLE MDM2 PIK3CA PMC4079587__F5 Interaction of kisspeptin, estrogen and BMP-4 in regulation of GnRH production by GT1-7 cells SMAD6 SMAD1 DKFZp781O1323 BMP4 PMC4726671__F1 Hepatitis C virus life cycle CLDN1 EGFR LDLR NPC1L1 RHO APOE CD81 PMC4077471__F3 Examples of pathway engineering and combinatorial biosynthesis to generate new analogs: A HAL TEC PMC9126881__F8 M2 macrophage-derived extracellular vesicles (EVs) on the development of ankylosing spondylitis (AS) through by transferring of microRNA-22-3p RUNX2 PER2 WNT7B PMC8462485__F9 Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NFKB/NLRP3 Pathway NLRP3 TLR4 CD40 CD80 IL1B PMC5499174__F1 The assayed components of the IIS/TOR pathway and their proposed interactions in D TSC1 SIK2 MYC PTEN RHEB PMC3745370__F8 High expression of the ppGalNAc-T13 gene enhances cancer metastasis by formation of trimeric Tn antigen SDC1 ITGB1 TTN PMC4276719__F10 Fatty acid metabolism in bacteria AASS FADD MCAT PMC7796222__F5 Postulated metabolic pathway of Alpha-PHP and 4F-Alpha-PVP F2 F5 F3 PMC4867327__F9 Schematic diagram illustrating lipid droplet formation, VLDL secretion, and pathways involving hepatic inflammation NLRP3 COX2 APOB PC ADFP HEL-S-70p TG IL1B SMS MTTP APOE PEMT PMC2864659__F6 APE1 has dual roles in redox and DNA repair EGR1 OGG1 TF HLF PMC9197245__F7 Strontium Regulates the Proliferation and Differentiation of Isolated Primary Bovine Chondrocytes via the TGFB/SMAD Pathway ALPL RUNX2 opn SMAD4 ACAN COL2A1 SMAD1 TGFB1 DKFZp781O1323 COL10A1 SMAD9 PMC6491380__F9 Reversion of HIV-1 latency regulated by DCs TSC2 CD9 PI3 TSC1 CDS1 CD151 CD83 PTEN CD81 PMC8613610__F2 Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease CS PC AMICA1 ABCG1 ABCC1 ABCA1 SPNS2 PMC6652211__F6 Possible EPO signaling pathway PLCG1 EPOR EPO BCR EPHB4 PMC2683382__F2 Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites IL33 TEC TRAF6 IRAK4 MYD88 IL25 IL17RB TSLP STAT3 PMC3730428__F8 Schematic diagram summarizing the key findings CASP3 RIPK1 TRADD TNF TRAF2 CASP8 FADD PMC3906322__F2 STAT2 and IRF9 TBK1 STAT2 IRF9 ATF2 DUOX2 TRAF6 RIGI IRF3 IFNAR2 IFNAR1 DUOXA2 STAT1 UNK TYK2 JAK1 MAVS PMC6163297__F6 Schematic drawing of the possible signalling pathways regulated by PACAP in bone formation BMP6 IHH RUNX2 PTCH1 SHH SMAD4 BMP7 SMO SMAD1 DKFZp781O1323 PMC5814345__F6 Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma HGF SP1 PMC7961955__F7 Common signaling pathways in liver disease (primarily HCC) and the kinase inhibitors aimed at these pathways KIT RET EGFR SRC FLT3 MTOR AXL PMC2080843__F5 Simulation of the Apoptosis pathway under FasL stimulation (black starred line), bacterial only (red circled line) and both (blue triangled line) CASP3 CASP9 CASP8 BAX PMC5986551__F5 Network analysis of differentially expressed genes in glioma cells exposed to exosomes XCL1 DRGX CSF3 C1QTNF2 CXCL8 PAPPA2 CCL2 CSF2 IL1B KCNT2 KCNJ3 PMC4977841__F1 Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b SUFU SHH SMO PMC10151263__F8 Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway ULK1 TFEB MTOR TRPV1 PMC3360921__F8 IQGAP1 regulates cell homeostasis through mTORC1 EGF IQGAP1 MTOR CDC42 PMC5986551__F2 MS and network analysis of hypoxic exosomal proteome RPS4X HNRNPAB NPM1 EIF3A FBN1 EIF3S6IP RPL19 SF3A2 RPL23A CCAR2 MMP3 SMC1A EIF3K HGS EIF3B HNRNPA2B1 HDAC2 EN1 HEL-S-133P MVP HSPA4 ROCK2 LOXL2 NAMPT LAMB2 LMNA GRN COPB2 NFKB2 COPS4 SCAMP3 EIF3S3 HEL113 PSMD2 RPS3 PML PIG59 HEL-S-97n TPR PRKCSH SH3BP4 HEL-S-111 THBS1 RPS6 FKBP4 PRKDC PRPF8 FASN RPS14 RRBP1 PPM1G BMPER HNRNPA0 RPS27L RPS9 SERPINE2 PS1TP5BP1 RPS3A EIF3C HEL-S-162eP COPE HEL-S-1a PMC6235777__F1 Graphical representation of IFNG signaling pathway RARA BOC PLAA FOS AREG DAP SRC PMC8016451__F8 Schematic diagram showing the mechanism by which Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis LDLR HMGCS1 HMGCR PMC9025063__F6 Genome Integrity and Neurological Disease ATM BLM BRCA2 EME1 RAD51 RBBP8 DNA2 PAXX PMC11648684__F10 Main mechanisms involved in the regulation of oxidative stress by m6A METTL14 DGCR8 SLC22A17 METTL3 NRF1 KEAP1 ABCA5 HECTD4 WTAP PRDX3 TFAM COX5A PMC9025063__F5 Genome Integrity and Neurological Disease POLE XPC XPA LIG1 PMC10198048__F7 Working model of how Cas regulates osteoclastogenesis CTSK NFATC1 MMP9 DCSTAMP TRAF6 PMC4499510__F1 WNT/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 TNKS PMC9025063__F4 Genome Integrity and Neurological Disease FEN1 PARP1 LIG1 PCNA PMC8798237__F4 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis CASP3 AIFM2 ATM CDK2 MYC MDM2 CYC1 PIGS PTEN ATR PMC2639448__F1 Intrafollicular predictors and regulators of oocyte quality within the oocyte–somatic cell regulatory loop GREM1 SMAD2 PTGS2 BMP15 HAS2 SMAD1 DKFZp781O1323 PMC5445212__F1 Endosomal transport channels and regulation of lipoprotein-derived cholesterol in hepatocytes.In many models, it was thought that cholesterol from all sources would enter a common regulatory pool before subsequent trafficking and regulatory steps ABCG8 ABCG5 LDLR ABCA1 HMGCR ACAT2 PMC8047423__F2 Molecular mechanism governing cell quiescence and torpidity in contrast with cell proliferation and euthermia PML TSC1 PDK2 MEIS1 PTEN PDK4 MTOR TF PMC11648684__F11 M6A is involved in regulating the immune function of innate immune cells neutrophils, macrophages, NK cells and adaptive immune cells T cells and B cells NOTCH2 YTHDF2 METTL14 TNC METTL3 PREB WNK1 NLRP13 ALKBH5 PMC140192__F7 Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF NODAL SMAD2 EGFR SMAD4 PMC4884928__F4 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state MYB DEFB4B GLB1 EZR PFKFB4 RB1 MFN2 IL16 OAS3 POMC NPY SHH DKC1 MAPK1 UGT1A3 IRF7 RUVBL1 SUPT20H FOS VEGFA UGDH TNF MCM3 PPP1CC CYFIP2 BDNF HEL-S-62p EGF IFITM3 MYL6 CCNC MX1 BMP4 IL18 MTF1 CFD CYP2C19 MT2A PTPN11 APP CCND1 RHOB JUN ITGA1 NOTCH4 CFB PTGS2 SKP1 ARHA IKBKB PES1 RAN CSF1 PMC3159954__F3 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa ISG15 RBX1 PMC3159954__F2 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa IFIT3 STAT2 IRF9 TYK2 JAK1 PSMB8 PMC7763666__F5 Wingless-type (WNT) signaling pathway NLK HEL-S-28 APC MDM2 SRC SFRP1 DKK1 MAP3K7IP1 JUN HDAC1 PMC8798237__F3 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis E2F4 DBF4 CDK7 CDC45 ORC2 HP CDK2 MDM2 CYC1 CDC2 PCNA SKP2 MYT1 MAL PMC4815022__F4 Identified signaling pathways downstream to glycine in NSCs HHIP BMP6 CDKN1A SESN3 CAMK4 GNA14 TGFBR2 SHH SESN1 SESN2 WIF1 CASP8 PMC4884928__F5 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state STAT2 IRF7 IFITM3 IRF9 EIF2AK2 BCL2L1 IL6 HIF1A STAT1 ISG15 CASP9 CSNK2B CYCS STAT3 PMC7596088__F3 Role of TGFB, IL-6, and IL-1B signaling pathways in PDAC EMT CCL20 CXCL12 IL1B PMC5567228__F6 Wnt/FZD4 signaling pathways through the interaction of miR-204 with FZD4-miR-SNP (rs713065) variant in NSCLC cells APC MYC CD44 LRP6 DKK1 IL6 RAC1 MAP3K7IP1 WIF1 FRZB CALM1 NLK NRP1 MDM2 SRC CCND1 DVL2 SFRP1 ETS2 TGFB1 TCF4 F11R PMC8865078__F7 Transforming Growth Factor-Beta-Regulated LncRNA-MUF Promotes Invasion by Modulating the miR-34a Snail1 Axis in Glioblastoma Multiforme SMAD2 SMAD4 CAPRIN2 PMC8472533__F1 New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment LATS1 PMC7559338__F6 Experimental verification of TFAP2C regulating EGFR in A549 cancer cells EGFR TFAP2C MAP2K2 PMC10759702__F7 Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy NFKB1 CEBPA IL6 SP1 TNF JUN IL1B TLR3 CEBPB IFNG STAT3 PMC5298863__F4 Intracellular signalling pathways that are activated by insulin and amino acids after feeding and that lead to the activation of translation initiation in the immature skeletal muscle TSC2 RICTOR TSC1 PTEN EIF4E RPS6 MTOR RHEB PMC9344793__F3 Cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics ACAT1 ABCG8 SRA1 ABCG5 ABCG1 LPL LDLR ABCA1 CD36 ACAT2 PMC6590595__F1 WNT signaling model APC GSK3B PMC8577929__F1 Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function TSC2 ULK1 KEAP1 IL6 PMC6618143__F3 Macrophage metabolic pathways IL16 SUCNR1 PFKFB1 ACLY ARG1 ACOD1 PMC10375641__F5 Super-enhancers complexes zoom in transcription in cancer SOX2 MAX FOS EGFR MYC PMC11364386__F1 Blockade of secretory vesicle biogenesis provides a therapeutic strategy for targeting cancer PLAUR ATP2C1 GOLIM4 GOLPH3 PMC4419472__F9 Schematic diagram describing the effect of oroxylin A on the inhibition of p53 degradation through the suppression of PTEN-regulated MDM2 expression MDM2 PTEN SIRT3 PMC8089133__F4 Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study TBK1 COX2 CD47 MALL MDP1 POR TNF TRAF2 FADD TAB3 PMC8452151__F4 Mechanisms that decode combinatorial and temporal codes of pathway activity to achieve stimulus-specific responses CEBPD ATF3 IRF3 IFNB1 TNF PMC9313267__F2 Mechanism and Role of ADAMTS Protein Family in Osteoarthritis NOS2 COMP VIP PMC8452151__F2 Molecular mechanisms for combinatorial encoding to achieve stimulus-specific responses TLR4 TRADD IRF3 MYD88 TLR3 MAVS TIRAP PMC8588641__F7 Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis SMAD2 ID1 PMC2949386__F6 Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity HGF FOS PTGS2 GRB2 PTPN11 RAF1 JUN PXN CRKL STAT3 PMC6110613__F2 Exploiting vita-PAMPs in vaccines TLR8 IL16 CXCR5 IL1R1 IL1B ICOS PMC4493053__F7 Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition SUFU PTCH1 GSK3B SHH SMO PTEN MTOR PMC2731733__F5 Cytoskeletal Remodeling: FAK Signaling pathway is enriched for HeLa and TOV edge hits using PIPA but not node hits using HGA enrichment GSK3B TRAF3 SHE FARP2 ARHA RHO HRAS CDC42 PMC4450261__F1 Activation of the Keap1-Nrf2-ARE pathway by oxidants/electrophiles MAF KEAP1 PMC5945923__F1 Cross talk between E2–estrogen receptorA (ERA) signaling pathways and circadian rhythms in breast cancer MMP2 SRC PER2 TF PMC7179206__F6 (−)-epicatechin anticancer activity in MDA-MB-231 and MCF-7 cells BAD HTRA2 BAX PMC5528412__F1 Simplified representation of the PI3K signaling pathway TSC2 PI3 PTEN INPP4B RHEB PMC5536354__F7 Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes EGF BAD PAX2 EGFR RHO PMC2722335__F1 Adipocyte lineage commitment and terminal differentiation BMP2 BMP4 PMC10706592__F3 TRAIL signaling pathway indicating the therapeutic targets modulated by flavonoid compounds FADD PMC10706592__F1 TRAIL signaling pathway FADD BAX PMC9414016__F1 Dual role of fucosidase in cancers and its clinical potential GMDS FUCA2 FUT1 FUT4 FUT6 POFUT4 FUT5 hCG_1998026 POFUT2 FUCA1 FUT7 FUT3 POFUT3 POFUT1 FUT8 FUT9 PMC6295312__F1 Gene-level alterations in muscle-invasive bladder cancer in the context of curated pathways AMER1 RIT1 MXD1 NCOR1 KEAP1 ALK SMAD2 PCDHJ MYC GSK3B SMAD4 RB1 CDKN2A FBXW7 FGFR2 CDK6 TAOK1 CCNE1 TAOK2 NF1 FGFR1 MNT MAPK1 PSEN2 YAP1 ERBB3 APC LRP5 TCF7L2 MLX DKK4 RHEB RICTOR TSC1 MAX CDKN1A STK4 AXIN1 STK11 MXI1 MGA CRB1 MAML3 DKFZp781B1423 TGFBR1 JAG2 TGFBR2 PPP2R1A INPP4B CCND3 KDM5A CCND2 ARRDC1 ERBB4 NF2 SFRP1 AXIN2 ARAF KIT WWC1 PDGFRA TAOK3 RAC1 CBL CREBBP EP300 MYCL ERBB2 CRB2 CSNK1D FGFR4 DKK1 ACVR2A TLE4 MDM2 ROS1 ZNRF3 CDKN1B DCHS1 FAT1 RET CDKN2B ACVR1B TLE2 MLXIP TLE3 IGF1R DNER BRAF EGFR PTEN LATS1 DKK2 MTOR MOBKL1A RPTOR TEAD2 ATM PTPN11 CCND1 CDK4 SPEN KAT2B RNF43 DKK3 NTRK1 FGFR3 MAP2K2 FAT2 WIF1 FAT3 FAT4 MAP2K1 hCG_2014051 RAF1 FLT3 SOS1 PMC6152364__F4 Relation between mammalian MAPK cascades and other kinases capable to induce cell responses involved in cancer RAC1 MTOR CDC42 PMC9120629__F1 Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder C9 CS C4B_2 C7 C6 C1S PMC7479251__F4 Notch signaling pathway, including targets and drugs that could be employed to inhibit it RBPJ DLL4 JAG2 DLL3 PMC7479251__F6 Hippo pathway including targets and drugs that could be employed to inhibit it NF2 LATS1 LATS2 PMC7479251__F5 Sonic Hedgehog canonical signaling, including targets and drugs that could be employed to inhibit it KIF7 SUFU GSK3B PMC8526190__F1 Neutrophil Extracellular Traps (NETs): Opportunities for Targeted Therapy CS MPO PMC7479251__F7 TLRs pathway including targets and drugs that could be employed to inhibit it TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 PMC3049553__F1 MAPK pathway activation in melanoma NRAS GRB2 SRC PTEN MTOR PMC8602415__F7 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows ITGB4 ITGA6 ITGB7 MDM2 THBS1 ITGB1 PMC8602415__F6 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows TNFRSF12A LEFTY2 DUOX2 TRIB3 ALOX5 NRIP3 GPR82 TMEM218 B3GALT1 PARP15 SERP2 FGFR1 SLAMF8 NRIP2 opn ENY2 CYP1A1 RAVER2 DIPLA1 ATP2B3 CRYBA4 RAD21 SCARB1 AREG RAB40C DUSP5 TNFRSF8 GNAS PMC8211227__F3 Schemetic drawing of carbon fixation in photosynthetic process (adapted from KEGG pathway zma00710) ME2 PDK2 ME3 PCK2 PMC3060875__F3 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses FOS CCL20 CCL7 SP1 JUN PMC3060875__F5 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses FYN LCK VAV1 ZAP70 GRB2 CD80 LAT PMC4959673__F6 HRPII recognition by human brain endothelial cells and the intracellular pathway that leads to BBB leakage VCAM1 MYD88 IL1B PMC8399750__F1 Nrf2 Pathway in Ischemic Stroke: A Review MAF CALCOCO2 ULK1 MARCO KEAP1 IL17D NQO1 CD36 PMC7262827__F6 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes that play significant role in cell cycle and cell proliferation E2F4 CDK2 SMAD2 GSK3B SMAD4 DBF4 ORC3 CDK7 PCNA SKP2 MYT1 PMC9500598__F2 Circular RNAs Involved in the Regulation of the Age-Related Pathways TSC2 TRIL TSC1 GSK3B MDM2 INS PTEN MTOR DEPTOR RHEB INSR PMC9500181__F1 Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes GPX4 LPCAT3 FACL4 KEAP1 SLC7A11 SLC3A2 DHODH PMC7262827__F5 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes in p53 signaling pathway CASP3 TSC2 PERP ATM CDK2 SUI1 FES MDM2 CASP9 PTEN ATR RFWD2 PMC7602998__F1 Events after colorectal surgery leading to AL MBP FPR1 MYD88 IL1B PMC3652374__F4 PPARG as a key regulator of lipogenesis in adipocytes and hypothetical major target for inhibitors of insulin-stimulated lipogenesis in obesity IL1B IFNG PMC7016007__F7 Crosstalk of metabolic pathways in AMD PARP2 SIRT1 RPTOR HEL-S-32 PMC3426783__F4 IPA network analyses were applied to differentially expressed genes in mouse brain after in vivo ketamine exposure LDB1 AREG NEUROG1 TNNC1 PRKG1 PRPF38B FOSL2 ZMYND19 PNMA1 CYP51A1 PAX4 CBFA2T3 PI3 NKX2-2 HNF4A TRIM63 ITGA6 CRB3 GJB1 TNNT3 IGF2R PMC4593152__F4 Conditional probability and local structure extracted from the simplified network, for calculating the indirect effect of this specific pathway (NAFLD, GGT1, GGT2, dyslipidemia, hypertension and MetS) PMC3652374__F2 Insulin signalling exerts rapid stimulation of glucose transport as well as fatty acid uptake, synthesis and esterification to triacylglycerol (TG) LPL TG PMC3652374__F1 Insulin signalling attenuates cAMP-mediated lipolysis at multiple steps in adipocytes PDE3B PDE5A PLIN1 GRB10 TG IRS1 INSR PMC5891907__F1 Scheme of the innate immune response to injury TLR4 IRF3 CCL2 MYD88 PMC5466160__F1 Autophagy pathway ULK1 ATG12 ATG3 ATG10 DKFZp686F0183 PMC8800599__F1 Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy NLRP3 KEAP1 CSA2 PMC4533772__F3 Analyses of interactions among SHRSP-specific genes RYR1 ZBTB16 EPHX2 CYP1A1 APOH BANP VEGFB AGTRAP GABRR1 CCR1 PMC5098802__F2 Injury site-specific targeting of complement inhibitors for treating stroke HEL-S-62p PLG CRP CAD CR1 PMC4765310__F2A Importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes TBK1 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 PMC3721730__F2 TRAIL-mediated extrinsic pathway of apoptosis HDAC7 FADD PMC11436262__F4 PPM1G participates in the occurrence and development of hepatocellular carcinoma and liver fibrosis via different pathways PRMT1 SFRS3 NOTCH3 CASP8 HES1 PMC3721730__F1 Intrinsic and ER pathways of apoptosis BAD BAX PMC11436262__F3 PPM1G-associated signaling pathways TSC2 TSC1 PPM1G ID1 PMC4533772__F2 Analyses of interactions among SHR-specific genes ITGA1 SOX2 CYP24A1 TSPAN1 RXRG NEFH AGTRAP CFTR ANKRD35 BCL6 PCDH9 SPIB GC ZBTB16 TP73 EPHX2 GDNF APOH JUN PMC11881679__F2 AAT is involved in the regulation of the cell signaling pathways and the pathogenesis of disease STS GRB2 TRAF6 IRAK4 MYD88 TRAF2 FADD TAB3 PMC5841291__F8 Sotetsuflavone inhibits non-small-cell lung cancer cell invasion and metastasis CDH2 MTOR PMC5083753__F3 Anticancer and analgesic activities of B‐caryophyllene (BCP) and B‐caryophyllene oxide (BCPO) BCL2 MTOR STAT3 PMC2953155__F5 Model schematic of Nipah virus-triggered DC immune response mechanisms and antagonist activity of the response IRF7 CCL4 TYK2 JAK1 PMC10471462__F2 Hippo pathway is involved in T cell development FOXO3A F3 DOCK8 RAC1 MOB1A MOBKL1A FOXO1 STAT3 FOXP3 PMC6461132__F1 PRR signalling pathways NLRP3 NOD1 BCL10 IRAK1 TRAF3 SYK IRF3 RP2 PLCG2 MAP3K7IP1 NOD2 PMC10471462__F1 Hippo pathway is a signaling pathway that regulates the self-renewal and differentiation of hematopoietic stem cells (HSCs) RUNX1 NF2 LATS1 RHO LATS2 CDC42 PMC6461132__F3 Negative Regulation of PRR-induced signalling NLRP3 BCL10 SYK NOS2 PMC10471462__F3 Hippo pathway is involved in megakaryopoiesis (upper panel) and erythropoiesis (bottom panel) CD34 MDM2 FSTL1 ARHA INHBA PMC4083854__F2 Diagram showing the effects of knockout or blockade of specific elements of the alternative, classical and lectin pathways of complement activation on the pathogenesis of anti-MPO induced murine crescentic glomerulonephritis HEL-S-62p MASP1 C6 MASP2 C4A PMC11019012__F2 Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy BAD FADD BAX PMC8087671__F3 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes PIG59 USP21 TRPM7 ZBP1 NLRP3 RIPK1 TLR4 CYLD H2AX PFKP HEL-S-133P HEL-S-281 BAX HMGB1 HEL-S-30 RIPK3 PARP1 ADH5 TNF TLR3 HEL-S-162eP HEL-S-68p HEL-S-49 ALDH1A3 IL33 BCL2 OSM TRAF2 FADD PYGL MLKL GLUD1 PMC7813674__F1 NFKB signaling pathway TLR5 TLR9 TRADD IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 TRAF5 TRAF2 TAB3 PMC8558653__F5 Mucin 1 promotes tumor progression through activating WNT/Beta-catenin signaling pathway in intrahepatic cholangiocarcinoma MUC1 MMP7 CCND1 PMC9646327__F8 Virtual Screening and Network Pharmacology-Based Study to Explore the Pharmacological Mechanism of Clerodendrum Species for Anticancer Treatment PGR ALK EGFR TGFBR2 MTOR PDPK1 CHEK2 PRKCA FLT1 KDR KLK3 SRC HEL-S-30 MMP9 FGFR3 CD44 HRAS BRCA1 AURKA HEL-S-22 CASP3 BRCA2 TNFSF10 PRLR PIK3CA COIL TERT PMC3759173__F3A Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy ANK2 KYNU LCN2 MAP3K7 TNFRSF19 NFKBIZ LY96 CRADD HLA-DMB RYR2 HLA-DOA HLA-DMA PMC3469060__F6 Putative mechanisms responsible for UPR activation by CD147 in human HCC cells YY1 HIF1A TF PMC7526978__F2 Z-nucleic acid-dependent inflammatory signaling pathway RIPK1 RIPK3 ZBP1 MLKL PMC8042276__F4 Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential SMAD2 HDAC11 HDAC5 HDAC1 TET2 FOXP3 IFNG TBX21 IL17A EZH2 SIRT1 KDM6B GATA3 PMC7924357__F1 Angiogenesis pathways in malignancy and targeted therapies commonly used EGF EGFR MTOR PMC9059429__F1 Rodent Genetic Models of Ah Receptor Signaling AHRR AHR CYP1B1 PMC7920551__F8 Model depicting lymph gland progenitor heterogeneity and response to immune challenge LAT TERT PMC3852779__F2 Hepatic genes differentially regulated by 17Beta-trenbolone: Impacts on metabolic pathways CYBA SDHC CYP46A1 MPO CYP24A1 PROX1 CYBB CYP51A1 TDO2 CYP27A1 CYP2C9 EPX CYP3A4 CYGB CYC1 DOCK2 CYP2A13 CYCS PMC6941129__F4 Regulation of the G1/S transition by the Greatwall-Endosulfine-PP2A/Cdc55 pathway in budding yeast CDK2 CLN3 CDC2 PMC9451157__F5 Pathway and mechanism analysis of F1-mediated chemoenzymatic synthesis of benzimidazole SET C4A PMC4663159__F7 The integration of the DUOX2 system into the intestinal epithelial defense response CXCL1 APC CCL20 DUOX2 REG3G PMC12109299__F1 HER2 signaling TSC2 TSC1 EGFR PTEN PMC6723600__F1 IL-38 signaling pathways SIGIRR IL1R1 MYD88 PMC11478363__F5 Research Progress on the Mechanisms of Protocatechuic Acid in the Treatment of Cognitive Impairment STAT1 CASP3 MAP2K1 MAP2K4 CASP9 BCL2 MYD88 SIRT1 BAX PMC6321632__F2 mRNA translation stress feedback to ribosome biogenesis and cell proliferation MTOR POLI PMC7367634__F6 Resistance mechanism to vemurafenib NF1 NRAS PTEN MTOR PMC8732282__F8 Proposed model depicting the therapeutic mechanism of GRB7-PLK1 axis inhibition to overcome MEKi resistance in KRAS mutant colon cancer cells PLK1 GRB7 STAT3 PMC3905281__F5 Wnt signalling pathway in developing muscle-less humeri FGF4 TNIK CLDN1 PITX2 SALL1 JAG2 CD44 RXRG DKK2 CACNG1 TCF15 ISLR2 CCNB3 RSPO3 PITX3 KCND1 PRG4 GREM2 SNAI3 EPHA4 CPZ ELAVL2 PMC11677171__F2 Molecular mechanisms responsible for the suppression of T:B cell cross-talk in inflamed glandular tissues MSC STAT3 FOXP3 PMC3516044__F3 Changes in the Plasmodium falciparum redox flux network after MB drug action.Notes: Results incorporating the transcription data and experimental mRNA expression data nine hours after incubation with methylene blue are shown RET POTEE PMC3759173__F4A Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy JDP2 GIG8 CTSK F8 LPXN CSF2RA IFI16 PMC11677171__F1 Effects of MSC-derived immunomodulatory and growth factors on survival, migration, phenotype and function of immune cells and parenchymal cells in inflamed and injured lacrimal and salivary glands BAD HGF MSC FOXP3 PMC5843896__F7 Our working model KEAP1 AQP1 GSK3B PMC8099467__F4 Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis CRY1 CREB3L3 VHL PER2 PER1 PMC8087671__F2 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes MPV17 NUDT12 PEX7 DAO AMACR CRAT BAAT PTS VWF EPHX2 XDH DHRS4 CROT PRDX5 ddo FRAS1 CD47 FREM2 LOC51064 NUDT19 NUDT7 PIPOX PXMP4 HMGCL CD44 MVK PEX16 FREM1 DMP1 PEX3 PEX13 PEX14 PMVK PEX6 PEX5 VTN DBP PEX2 PEX10 PAOX CHAD PEX12 PECR PEX26 MLYCD PHYH CD36 PXMP2 PMC5159197__F1 IgA Nephropathy Enigma C1GALT1 CIC GAL PMC1599906__F3 TGFB signaling pathway NODAL BMP2 SMAD2 GRB2 SMAD6 SMAD4 BMP7 SMAD1 HDAC1 TF DKFZp781O1323 BMP4 PMC6097464__F5 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set BAD FLNA EGFR MYL2 PTEN CCND3 PARVA CCND2 ITGA2 PRKCA PDGFD FYN LAMB4 TLN2 BIRC3 THBS1 CAV2 LAMC2 HEL-S-28 ACTN2 LAMA4 MAP2K1 SHC4 ITGAV LAMC1 PXN VAV2 PMC11062983__F7 pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells IL6 IL6R STAT3 BAX PMC6097464__F7 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set TH BAMBI ACVR1 ARHH E2F5 TNF SMURF1 LTBP1 FST NOG BMPR2 HEL-S-11 SMURF2 THBS1 INHBA PMC8313741__AF1 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression SOX2 SIRT1 PMC6097464__F6 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set IKBKG FLNA EGFR RELB RRAS PTEN NAT2 TNF FGFR2 FGF20 PRKCA NFATC2 CACNG4 DUSP10 MAX DUSP14 MEF2C TGFB1 PMC6097464__F9 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set BAMBI FST LTA ITGAV THBS1 TNF UNG GP1BB LAMC1 LAMA3 LAMC2 PMC6097464__F8 TGF-beta adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2404 set SOS2 ATF2 DUT PTEN SLK RPSA PMC4935144__F1 Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway TSC2 TTI1 GRB10 MTOR DEPTOR IRS1 RHEB PMC7367634__F1 MAPK and PI3K‐AKT‐mTOR signaling pathways BRAF IGFBP7 MTOR PMC8455332__F1 Suppressive actions of regulatory T cells APC CD80 CTLA4 PMC4015186__F1 MiRNA Regulation of the Human Glycome ALG11 MAN1B1 DPAGT1 ALG13 GANAB MGAT3 PRKCSH MGAT4C GNPTAB ALG1 NAGPA GNPTG ALG3 GCS1 ALG6 ALG10 MGAT2 PMC7907026__F2 Diverse roles of the immune checkpoint in tumor cells that drive to the stimulation or inhibition of metastasis CD47 EGFR BTLA NOS2 MTOR STAT3 BAX PMC4015186__F4 Insights into MiRNA Regulation of the Human Glycome ABO hCG_1998026 PMC4556941__F2 Key mechanisms regulating vascular smooth muscle tone ADRB1 CNP PMC11481580__F7 Transcriptome sequencing analysis of overexpressed SikCDPK1 in tobacco reveals mechanisms of cold stress response BAK1 MYC MKS1 RAN PMC6249818__F6 Therapeutic targeting of the FOXM1 genetic network in myeloma FOXM1 NEK2 CDK4 PMC8173054__F1 Endocannabinoids and Precision Medicine for Mood Disorders and Suicide NAPEPLD FAAH TRPV1 GPR119 PMC7288916__F8 H19 in regulating dopaminergic neuron loss in PD PITX3 NEUROD1 PMC9095977__F3 Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse HMGB1 CXCR4 CXCL12 PMC4409212__F1 Novel Cancer Chemotherapy Hits by Molecular Topology: Dual Akt and Beta-Catenin Inhibitors TSC2 RICTOR BAD TSC1 MDM2 MTOR RHEB CDC42 PMC7140443__F1 Off state (left): In the absence of Sonic Hedgehog (SHH) ligand, Ptch inhibits signal transduction by SMO SOX2 SUFU PTCH1 MYC SHH SMO PMC7140443__F4 Role of SHH/Gli cascade in Ewing sarcoma development FLI1 SUFU PTCH1 SHH SMO PMC4800317__F6 Non-canonical or alternative NFKB pathway TRAF3 LTB RELB CD40 TRAF2 LTBR PMC4800317__F5 Canonical or classical NFKB pathway BCL10 BCR TRADD IRAK1 EIF2A TRAF6 IRAK4 MYD88 TRAF2 TIRAP PMC5889982__F1 Beta-arr is a potential therapeutic target for various diseases CXCR4 EGFR GSK3B CXCL12 MTOR MLST8 PMC5473974__F2 The glucocorticoid receptor and nitric oxide signaling pathways TBP ADRB2 PMC6721829__F2 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies CCND1 PTEN MTOR STAT3 PMC11652206__F2 Mechanisms by which phthalates affected sex steroids-related pathways SCARB1 MAPK10 DBP FGF10 MAPK14 SHH CYP11A1 SRD5A2 HSD17B3 CYP17A1 STAR BMP4 PMC6331208__F1 Neuroprotective effects of DBS at the synapse CASP3 TFEB BDNF BAX PMC6721829__F3 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies CCND1 BCL2 PTEN STAT3 PMC11652206__F4 Mechanisms by which phthalates affected autophagy HHIP DBP PTCH1 MTOR PMC3742248__F2 Role of miR-302 during human ESCs (hESC) neural differentiation NR2F2 TCF3 SOX2 LEFTY1 NODAL LEFTY2 PMC11652206__F3 Mechanisms by which phthalates affect epithelial-mesenchymal transition (EMT) ROCK2 ROCK1 PFN2 SMAD2 DBP SMAD4 CDH2 PMC5209621__F7 Classic mechanism for E2 action is E2 diffusing into the nucleus, binding to the nucleus estrogen receptor (ER), combining with ERE on DNA, starting transcription translation and inducing the cycle of multiplication in cancer cells CCND1 SP1 MTOR BAX PMC11652206__F7 Hypothesized macro-mechanism by which phthalates induce hypospadias VEGFA SRD5A2 STAT3 PMC8869699__F3 TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target CD14 MHC2TA CYLD NLRX1 TRAF6 ATF3 CD300A MYD88 TLR1 SOCS1 TIRAP MAL PMC8699626__F2 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective PLK1 AJUBA MCM7 LATS1 LATS2 CDK6 MCM3 MCM5 MCM6 MCM2 CDK2 NF2 CDK4 CDC2 PMC8699626__F1 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective FRY HEL70 ZYX NF2 AJUBA LATS2 PMC7808154__F2 Interleukin‐17 and ischaemic stroke KY TRAF5 EBP GSK3B TRAF3 TRAF6 TRAF2 TRAF4 TAB3 PMC10916417__F6 Relationship between PS, PC, and PE in the glycerophospholipid metabolic pathway PTDSS1 PC PHOSPHO1 PCYT2 PISD PTDSS2 PMC8693975__F1 Modeling and analysis of the macronutrient signaling network in budding yeast ELF2 EIF2A PMC9354686__F6 Oncogenic Role of miR-217 During Clear Cell Renal Carcinoma Progression IGF2 WNK2 IGF2BP2 PMC9670321__F2 GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models AMOT RHO MTOR TRIO PMC9104338__F9 In Vitro Effects of Papaverine on Cell Migration and Vascular Endothelial Growth Factor in Cancer Cell Lines HMGB1 PDE10A BCL2 PTEN MTOR PMC8548662__F3 Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma SOX2 NOTCH1 PMC4167215__F1 The mitochondrial unfolded protein response in mammalian physiology UBL5 LONP1 EIF2A PMC3157194__F4 Interaction between MAPK signaling pathway–related genes and miRNAs NLK NTF3 FOS EGFR PMC4039991__F1 Upregulation of a Steroid Synthesis Pathway in Th2 Cells In Vitro(A) Schematic representation of integrated steroid biosynthesis pathway with abbreviated metabolites (black) and protein factors (blue) SQLE EBP SC5D DHCR24 MVK CYP11A1 HMGCS1 HSD17B7 TM7SF2 HMGCR STARD4 PMVK MVD TBP DHCR7 FDPS FDFT1 LDLR CYP17A1 PBR STAR PMC5559108__F3 Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics FGA MMP10 EGF CXCL1 CCL11 NGF MPO MMP9 VEGFA BCAN NRP2 NTF4 NTF3 HEL-S-78p NGFR KITLG TGFB1 PMC5675652__F6 Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds LEP EGR2 SCD TRIB3 KLF4 CD36 PMC6231613__F3 Novel protein signatures suggest progression to muscular invasiveness in bladder cancer PRR9 KIF23 CST5 SLC26A2 POLG MTOR XBP1 SLC38A1 RICTOR FADS2 CNOT11 ELMO3 ELF4 PMC4084821__F3 Irinotecan Pathway, view of a model human liver cell showing blood, bile, and intestinal compartments, indicating tissue-specific involvement of genes in the irinotecan pathway SLCO1B1 UGT1A9 CES2 CES1 CYP3A4 APC ABCC1 ABCG2 BCHE ABCC2 ABCB1 UGT1A1 PMC5623821__F9 Self‐sustaining cancer cells in 3D HGF PROS1 EGFR SRC TYRO3 MERTK MTOR AXL PMC8267694__F1 Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something? BAD MDM2 BCL2 BAX PMC9693344__F3 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma FADD BAX PMC9693344__F2 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma KEAP1 RBX1 NQO1 PMC9832176__F2 TGFB signaling in the placenta via miR-574–5p mediated SMAD2/4 regulation SMAD2 SMAD4 PMC8390275__F5 Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population BNIP3 SIRT3 PMC3519901__F7 Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection RIPK1 TANK IRF9 IFNE IRF3 JUN FADD GYPB PMC11799081__F1 Apoptosis and Necroptosis RIPK1 FADD GSDMD PMC8186445__F2 Astrocytes in the Neurorepair Process PITX3 APC GSK3B NEUROD1 PMC8912934__F3 Tinker, Tailor, Tumour Suppressor: The Many Functions of PRP4K EGFR PTEN MTOR PMC6876279__F1 The JAK-Stat signalling pathway EPO TPO IFNG PMC11668132__F1 Quercetin on cancer cell growth and proliferation ATM APC EGFR PMC5817811__F2 HGF/c-MET signaling pathway HGF GRB2 RAC1 MTOR STAT3 PMC11220218__F1 Metabolic reprogramming in thyroid cancer and therapeutic resistance BRAF SHMT1 CIC MTOR PMC11668132__F2 Quercetin on cancer cellular biomolecules and functions BAD ATM RAC1 MTOR BAX PMC11058799__F7 Gene network crosstalk between selected DEGs (TYK2, STAT1 and TLR7) created with NetworkAnalyst software [44] STAT1 IFIT3 OAS2 TLR7 TYK2 JAK1 IFI27 PMC5420131__F1 Canonical Wnt/Beta-catenin pathway: “WNT ON state”: WNT proteins, by binding to frizzled receptors and the LRP co-receptor, act to suppress the activity of glycogen synthase kinase-3B (GSK-3B) ZNRF3 GSK3B TEF PMC4245912__F2 The secretory pathways used by NMDARs KIF17 CASK KIF1A PMC9682745__F3 Innate immunity, cytokine storm, and inflammatory cell death in COVID-19 STAT1 RIPK1 TNF IRF-1 ZBP1 PMC8036620__F4 Apoptotic pathways involved in CIAKI TRADD ATF4 FADD PMC9510148__F2 Contribution of altered neuronal autophagy to neurodegeneration ULK1 ATG101 ULK2 MTOR PMC5429338__F2 Main potential molecular mechanism of the antitumour effect of anthocyanins in vitro EGF MMP2 MMP9 SRC PCNA STAT3 PMC3633842__F6 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns ELF2 ELF3 EIF2A GRB2 CRAT INSR PMC3633842__F5 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns IFIT3 IFIT2 RSAD2 STAT2 IRF7 MX1 STAT1 ADAR OASL OAS2 OAS3 TNFSF10 GBP3 IFIH1 IFIT1 PMC3633842__F4 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns STAT1 IFIT3 OAS1 STAT2 IRF9 TYK2 JAK1 PSMB8 MX1 IFIT1 PMC5420131__F3 Immune exclusion through Wnt/beta-catenin pathway: Activation of Wnt/beta-catenin pathway in tumor leads to noninflammatory milieu through multiple mechanisms ATF3 CCL4 IL1B FOXP3 PMC3633842__F2 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns ISG15 TANK IFNA4 STAT2 PMC5420131__F2 Therapeutic targets in Wnt/Beta-catenin pathway and developmental therapeutics TEF PORCN PMC5070917__F1 Bruton’s tyrosine kinase in autoimmunity and implications for therapy BTK BASH LYN SYK PLCG2 PMC8154153__F6 Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells HEL103 SCFD1 COPG1 ZFPL1 PACS1 STX17 ARF3 TMF1 RAB32 PMC3946959__F1 Proposed signaling pathway for PCB detoxification in vivo AHR HEL-75 CYP1A1 PRX PMC5027289__F7 PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development WNT4 SF1 MC2R SHH CYP11B2 PMC8802865__F10 Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics TBK1 CGAS IRF3 PMC3364135__F1 EpCAM and its potential role in tumor-initiating cells LEF1 SOX2 EPCAM APC MYC CLDN7 FHL2 PMC11900955__F2 TBK1 in key mechanisms of inflammation-associated diseases TBK1 PMC4815185__F7 Visualization of all differentially expressed proteins mapped to the TCA cycle pathway in the development of RAW 264.7 cells into osteoclasts in low serum culture system PDHA2 CS PDK2 PDK4 IDH3B HEL-S-32 MDH2 PDK3 PDHA1 ACO2 SUCLA2 OGDH PDHX SDHD SDHA SDHB PMC9386326__F8 Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFB signalling pathway KEAP1 TGFBR1 UGDH PTBP3 PMC11900955__F1 Different immune cells by TBK1 TBK1 CGAS IRF3 CCL5 PMC6109055__F6 Model: SIRT6 levels regulate resistance or sensitivity to MAPKi IGF1R SIRT6 IGFBP2 TF PMC8738926__F4 Starvation-induced negative energy balance on endoplasmic reticulum stress in the liver of cows XBP1 NR1C1 ACOX1 PMC9502833__F2 Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture APC LRP5 LRP6 TF PMC6040832__F2 Progranulin, lysosomal regulation and neurodegenerative disease HEL-S-62p C1QA TFEB PMC3131688__F1 Autophagy in immunity and inflammation HMGB1 ATG16L1 CD46 ATG3 LIF ATF1 DAP MYD88 MTOR NOD2 VMP1 NBR1 NOD1 CLCF1 BCL2 CD40 IL4 CXCL12 STAT3 PMC4909416__F1 The CDC20-APC/SOX2 pathway in human GSCs CDC20 SOX2 APC PMC7823972__F2 MSC-exosomes are capable of protecting against radiation-induced damage to hematopoietic and nonhematopoietic systems EGF MSC PMC7957490__F1 Crosstalk between MSCs and immune cells in the initial phase of tissue injury MSC CCL5 CXCL2 CCL2 CXCL12 CCL3 PMC7116639__F5 Regulatory R-loops as effectors of gene expression and genome stability PALB2 BRCA2 DDX1 RAD52 RAD51 ATR BRCA1 PMC7059126__F1 Illuminating insights into opsin 3 function in the skin PC MC1R TRPA1 PMC12043700__F4 Main regulatory mechanism of irisin in osteoclasts NFATC1 OSCAR PMC12043700__F3 The improvement of osteoblast activity by irisin RUNX2 ATF4 SOST MTOR PTHLH HEL-S-133P PMC12043700__F6 Regulatory functions of irisin in osteoarthritis relief through modulation of chondrocyte metabolism MFN1 NLRP3 UCP1 IL1R1 TFAM SIRT3 PMC9490861__F3 Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments TLR4 MYD88 TLR1 PMC9592761__F3 Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention ITGB8 GSK3B ACHE MTOR PPARG DKFZp686F0183 PMC5602294__F1 Biosynthetic pathway of NAD+ production starting from Na NAPRT NMNAT1 NMNAT3 NADSYN1 PMC12043700__F2 Irisin in the regulation of MSC proliferation and differentiation ATG12 RUNX2 BMP2 SOST CEBPA MTOR HEL-S-104 DKFZp686F0183 SOX9 SMAD9 BMPR2 ACAN COL2A1 SMAD1 DKFZp781O1323 PMC4769825__F2 Schematic illustration of pathways associated with Nrf2 signal MAF KEAP1 PMC6737584__F3 Phosphorylation of central carbon metabolic enzymes PDC SDHC HEL-S-162eP PMC7890031__F2 IL-17A on osteoblasts RUNX2 BMP2 IL1B STAT3 PMC7890031__F1 IL-17A on osteoclasts TRAF3 NOS2 TNF PMC6276815__F3 Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience DLX2 TH SOX2 FEV ASCL1 ALK GSK3B INS LHX3 LHX6 DLX5 DLX1 ISL1 LMX1B GATA2 FOXA2 PITX3 FOXG1 REST MYT1L NEUROD1 TF PMC10298151__F7 Diagram showing the mechanisms involved in D2R Beta-arrestin-dependent pathway-mediated ERK activation MDM2 SRC ADRBK1 PMC9060145__F4 Preclinical assessment of dual CYP26[A1/B1] inhibitor, DX308, as an improved treatment for keratinization disorders PROC HEL113 PLEK UCP2 PMC9434538__F2 JMJD family proteins in cancer and inflammation ME1 ME2 JMJD6 IRF4 PMC10040548__F6 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis MTR PSPH PHGDH PMC10040548__F5 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis NAMPT HEL-S-90n CIT PHGDH MAL PMC5508010__F5 To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection TIGAR MYC PTEN PMC8295685__F1 Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases KIF7 SUFU PTCH1 GLI3 SHH SMO PMC3060380__F1 Myostatin activity and muscle growth BMP1 ACVR2B SMAD2 SMAD4 TLL2 TLL1 PMC2857179__F1 Mechanisms and pathways targeted by mutations in MPN NF1 EPOR EPO GRB2 TPO MPL TET2 CBL PMC7109607__F3 SOX2-expressing tumor cells as potential therapeutic targets SOX2 APC SHH PMC8351602__F1 Intrinsic and extrinsic apoptotic signaling pathways FADD BAX PMC3868569__F1 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans PMC3154417__F2 mTOR signaling pathway TSC2 TSC1 RHO PTEN MTOR RHEB PMC9489775__F5 Selected transcripts of developmental signaling pathway genes implicated in dorsoventral and/or anteroposterior patterning containing two or more RNA editing sites detected at their 3′-UTR region ABL2 DUSP4 HEL-S-28 ABI2 RNF146 LIG1 SDC2 FZD5 LLGL1 RNF170 ACVR2B KCTD10 DVL2 FERMT2 OCRL JAK1 PAF1 PMC4110478__F1 Hypoxia inducible factor and VEGF link the HIF/VHL and PI3K/Akt/mTOR signaling pathways EPO VHL PTEN HEL-S-133P ADM PMC7347234__F7 System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion PC DHODH PMC5508010__F4 Quiescent (A) and activated (B) metabolism in differentiated mammalian cells KIT F2 OGDH CIT RPE MAL PMC2937518__F4 Overview of predicted carbohydrate uptake and metabolism systems in bifidobacteria PTS FOS MIP GAL PMC5508010__F2 Schematic presentation of the basic catabolic and anabolic processes of a typical heterotrophic prokaryotic cell: glycolytic pathway (GL), pentose-phosphate pathway (PPP) with its oxidative and non-oxidative arms, and tricarboxylic acid cycle (TCA) CS OGDH CIT HEL107 RPE MAL PMC8384663__F1 Multifactorial pathogenesis of psoriatic disease FUT8 RUNX1 STAT4 CCL20 TYK2 KLK6 POR TNF IL23R TNFAIP3 IL12RB1 CARD14 PMC9459018__F4 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots POR ASL MAL PMC9609565__F7 Morinda officinalis Polysaccharides Ameliorates Bone Growth by Attenuating Oxidative Stress and Regulating the Gut Microbiota in Thiram-Induced Tibial Dyschondroplasia Chickens RUNX2 BMP2 GPX1 PMC11959002__F2 ncRNAs promote PCa metastasis through the PAM signaling pathway CUL4B PCDH9 CDC6 EGFR CCL20 PTEN EZH2 PMC7159845__F3 Cellular model of insulin and leptin signaling in Kiss1ARH neurons KISS1 TRPC5 PMC9459018__F6 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots KIT PC GDA ALLC ADK PMC11959002__F1 ncRNAs inhibit PCa metastasis through the PAM signaling pathway CUL4B LAPTM4B ZNF217 ERBB2 GAB2 ERBB3 NEK2 PTEN PMC3585121__F6 Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci GC LAT PRL PMC7147028__F8 Schematic diagram showing potential involvement of miR-761 inhibiting EMT in CRS mice through targeting LCN2 in the LCN2/Twist1 signaling pathway TWIST1 LCN2 CDH2 PMC11959002__F4 ncRNAs inhibit PCa growth through the PAM signaling pathway CUL4B KLF4 PTEN KIDINS220 EN2 PMC11959002__F3 ncRNAs promote PCa growth through the PAM signaling pathway EGFR CCL20 PTEN EZH2 PMC11959002__F6 ncRNAs regulate PCa tumor stemness through the PAM signaling pathway IGF1R FGFR1 SOX2 EGFR KLF4 BMI1 PMC11959002__F5 ncRNAs regulate PCa angiogenesis through the PAM signaling pathway RICTOR KIDINS220 MTOR PMC8190037__F3 Analysis of the role of PurA in the pathogenesis of Alzheimer's disease based on RNA-seq and ChIP-seq CASP3 SNCA CASP12 BAD APAF1 GSK3B LPL CASP9 TNF FADD APOE PMC3462655__F2 The signaling pathways involved in T-cell activation CSK LCK ARHA LTK LAT PMC5427104__F1 Activation and evasion of lectin pathway (LP) of complement HEL-S-62p C4B_2 PMC11508835__F4 Amino acid pathway interaction with mTORC1 SLC7A5 FLCN SLC38A9 CASTOR2 FNIP2 RNF152 CASTOR1 SLC3A2 SESN2 LAMTOR5 SKP2 PMC4310328__F1 Schematic figure of the complement system HEL-S-62p CD59 C9 CRP C7 C6 MASP2 CR1 CP PMC11508835__F3 AMPK signaling pathway STRADB TSC2 TSC1 TBC1D7 RHEB PMC6599710__F2 Genomic correlates of response to immune checkpoint blockade STAT1 IFNGR2 JAK1 B2M IFNGR1 MEX3B IRF-1 SOCS1 PMC9578007__F5 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis SPARC RETN NAMPT SELENOP EGFR GUGU RARRES2 MSTN AHNAK HSD17B13 IL6 TNF TNLG7C METRNL IL15 FST LEP TNR BDNF FNDC5 PMC11508835__F2 Insulin/PI3K/AKT signaling interactions with mTOR CHUK GSK3B TBC1D7 PTEN HRAS IRS1 PDPK1 RHEB TSC2 TSC1 MAP2K1 IGF1 GRB2 MAPK1 RAF1 GRB10 SOS1 PMC9578007__F4 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis SHBG FACL4 PPARGC1A LECT2 TNF PPARG NR1C1 FASN PMC11508835__F1 mTOR signaling pathway STRADB CASTOR2 LRP5 RNF152 CASTOR1 LRP6 PTEN DEPTOR IRS1 RHEB DVL1 TSC2 IKBKB TSC1 SESN2 GRB10 SKP2 PMC9578007__F3 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis EGFR INS TNF CDKN2A NR1C1 UCP2 FST TLR4 SLC2A4 PPARGC1A AHSG HEL-S-44 PPARG PMC9578007__F2 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis IL10 EGFR DPP4 MAP3K5 TNF HEL-S-104 NR1C1 LIPE TLR4 SLC2A4 PPARGC1A IL17A SLC2A14 RBP4 PPARG SMEK1 FASN PMC8525330__F3 CREB1 coordinates transcriptional networks in DCs and CD4+ T cells which drive key immune effector functions CYBA PIN1 CLTA TNFRSF14 E2F4 CREB1 SPN ASH2L TTF2 HEL-S-11 CCR7 PTK2B PSMB9 MCOLN2 BRWD1 MAPKAPK2 CNOT4 Nbla10317 CXCL10 LTB NUCKS1 MAP3K5 tal-1 UBQLN1 CDKN1A MAFK SYNC RORA ELF4 TBK1 PML CHUK HLA-G CUEDC2 UBE2D3 DOCK8 AP1B1 MAP2K3 RHOU IL18 TLR7 NOD1 CPEB3 NPTN CD47 SIN3B TBX2 CD200 IL24 ARHA HAX1 TNLG2B FLT3LG TAPBP TYROBP FOXA2 CREBBP PPARG APPL1 PMC5889818__F3 Schematic overview of three different modes of cell death: apoptosis, necrosis and necroptosis RIPK1 TRADD RIPK3 TNF FADD MLKL PMC3745930__F5 Roles of hnRNPs in the impaired granulocytic differentiation of BCR/ABL transformed myeloid progenitor cells BCR EBP FUS PMC3577828__F6 Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance TSC2 TSC1 IRS1 RHEB PMC4863733__F2 Birth of a Carcinoma-associated fibroblasts SPARC PDGFRA FAP SHH PDPN CXCL2 FOXF1 CD36 PMC4267804__F6 RNA-Seq Analysis of Equine Conceptus Transcripts during Embryo Fixation and Capsule Disappearance BAD PLG CASP9 SRC PMC10526236__F4 MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer RNF123 IRF7 TRAF6 IRF3 TRIM25 MAVS PMC5838471__F1 Metabolic pathway of AB and GPCRs in Alzheimer's disease ChAT BAD CDK5 APP GSK3A IL8RB GPR3 PMC11506742__F1 TLR/IL-1R signaling pathway IRAK1 IRAK2 TRAF6 IRAK4 MYD88 STAT3 PMC11506742__F2 IRAK1 in the metastatic cascade IL10 CXCL1 MCM2 VCAM1 IRAK1 CCL20 CCL5 CDC2 CDH2 TNF CDC45 PMC7432832__F1 Aryl hydrocarbon receptor (AhR) pathway AHRR AHR PMC7432832__F3 AhR pathway interactions in cancer breast cells TH AHR MYC IL6 PMC6280631__F2 The melanogenesis pathway shows where common ENAMs affect the pathway ENAM BRAF TYRP1 MC1R PMC2537559__F5 Alterations in adhesion-mediated signaling and cytoskeleton remodeling in metastatic cancer PLAUR HEL-S-28 VAV1 VEGFA ARHA DOCK1 PTEN EIF4H EIF4E HRAS PLAT CRB2 TRIO PMC2537559__F4 Alterations in extraceullular matrix and secreted proteins associated with metastatic cancer MMP10 EGF PLAT PLAUR IGF1 PLG IGF2 TIMP3 EGFR CD44 MMP16 SERPINE2 PMC2537559__F3 Glycolysis pathway ENO3 CS ENO1 ENO2 PGAM1 HEL-S-133P PGAM2 HEL-S-281 PMC4995061__F1 Plasticity of Arterial and Venous Endothelial Cell Identity – Some Nerve! EFNB2 NRP1 EPHB4 PMC6892980__F2 Macrophage exposure to Magnéli phases activates gene expression profiles associated with apoptosis and mitochondria dysfunction CYLD APAF1 TNFRSF1A BCL2 BCL2L1 MCL1 TNF DKFZp686F0183 BAX PMC4910072__F2 Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast SCD TEF ENG CENPK HK2 PMC7322824__F1 STRING connectivity network analysis identified protein–protein interactions between CUL2, EGLN1, RBX1, LDHA, TFRC, and PFKL MAP2K2 PFKL RBX1 HEL-S-133P EGLN1 PMC8945049__F4 Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease DDR1 NCK2 TPM3 MAPK14 KCNJ4 HEL-S-32 HAP1 AVIL AGA POU2F1 BRK1 MCHR1 GDI1 YWHAG MTO1 HEL-S-281 SDHB KDM1A SNCA POLR3H TAF1 RNF7 UBE2G2 SDHC POLR2K RGS4 APC GRIA3 UBE2H HEL110 GABRB2 CAB39 GAP43 RPH3A PS1TP5BP1 CALM1 DNCL1 EP300 PRKCB AP2S1 THBS3 OGT ATP2A2 PXN MYLK3 SYP CDC42 PMC11033503__F1 C/EBPB regulates signaling pathways associated with brain inflammation in AD HEL-S-62p BDKRB2 CD200R1 PMC4023866__F1 Bacterial effectors that target and manipulate the innate immune and inflammatory pathways CD14 TLR4 CLPX TRAF6 MAP3K7IP1 PMC11851453__F1 Two-end black (TEB) coat color phenotype, schematic diagram of EDNRB transcripts and their encoded protein, three-dimensional structure prediction of the EDNRB protein, and an EDNRB melanin pathway diagram EDN1 EDNRB PMC11033503__F2 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease SET GSK3B APP SRPK2 BDNF PMC11033503__F4 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease TRPC1 ORAI1 STIM1 PMC4300719__F6 Pathway analysis in groups A (A) and B (B) RARB FHIT BAD RASSF1 DAO ERBB2 GAB2 CASP9 PMC6057902__F2 Extended, context‐specific melatonin receptor signalling pathways BCL2 SIRT1 FOXO1 BAX SIRT3 PMC2934775__F9 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where nitrogen-limiting medium is changed to carbon-limiting medium at time zero PTS CIT MAL PMC2934775__F8 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where carbon-limiting medium is changed to nitrogen-limiting medium at time zero PTS CIT MAL PMC8530873__F1A Stress stimulus produces a physiological response which involves the central nervous system (CNS) and the periphery EGR1 CDKN2B ATM SIK2 SIK3 RAD51 ATR BRCA1 SIK1 PMC3038194__F1 Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer NRG3 EGF BAD FOS EGFR GRB2 NRG2 HBEGF NRG1 MTOR TGFA JUN PMC2515336__F2 Representation of the two NFKB signaling pathways RELA LTB RELB CD40 PMC2709856__F1 It’s all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection TLR4 TRAF3 TRAF6 IRF3 MYD88 MAP3K7IP1 TIRAP MAL PMC5859251__F6 TRIM29 regulating anti-DNA virus immune response through targeting STING TBK1 CGAS DDX41 IRF3 TRIM29 PMC2707763__F6 PROK1 induction of RCAN1-4 and IL-8 RCAN3 CA3 RCAN1 PROKR1 PROK1 PMC2268661__F2 The diagram of GSH redox cycle GCLM GPX4 GCLC HEL-S-64p PMC8245224__F9 Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells LCN2 VHL HK2 PMC6366148__F3 PI3K/Akt/mTOR pathway activated by IL-2 and CD28 signaling and growth factors IL7R MTOR PMC5833125__F2 Signaling networks in osteoclastogenesis BTK VAV3 NFATC1 BASH GAB2 GRB2 OSCAR TEC TRAF6 SYK MAP3K7IP1 TRAF2 PMC7520308__F1 Biosynthetic pathway of tetrahydrobiopterin: de novo pathway from GTP and two other salvage pathways from sepiapterin and 1′‐hydroxy‐2′‐oxopropyl‐tetrahydropterin, respectively SPR DHFR PMC2875112__F1A Targeting Multiple Kinase Pathways. A Change In Paradigm BAD GSK3B MDM2 PTEN PMC8394096__F1 Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review PAK1 BAD MDM2 PTEN BAX PMC10750291__F4 Biological mechanism and emerging therapeutic interventions of liver aging NLK MAX TRADD ATF2 PMC3146512__F2 Genome Sequence of a Mesophilic Hydrogenotrophic Methanogen Methanocella paludicola, the First Cultivated Representative of the Order Methanocellales POR CP PMC10750291__F6 Biological mechanism and emerging therapeutic interventions of liver aging TH E2F4 TRADD SMAD2 MYC WAPAL SMAD4 DBF4 S100A7 CDK7 CDK6 MTBP DDX11 KNTC2 MDM2 ESCO2 CDK4 CDC2 RAD21 TICRR MAU2 ESCO1 APC LCN2 S100A9 tal-1 CDC20 CDC6 SMC3 CDK2 FADD PCNA SKP2 TRIP13 PMC1681468__F6 Combinations of multiple states of complexes ERBB3 NRG2 NRG1 PMC10750291__F5 Biological mechanism and emerging therapeutic interventions of liver aging CD14 AIP CTSK TLR9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 PDC ATF4 LBP CD40 CD80 CAD FADD TIRAP PMC1681468__F5 Ellipsis in drawing association states of proteins using an 'address' EGF EGFR GRB2 SHE PMC4140976__F2 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging IGF1R IGF1 IRS1 PMC4140976__F1 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging TSC2 ULK1 BAD TSC1 GRB2 GRB10 MTOR RHEB APPL1 PMC7366241__F1 Non-coding RNA in GC LIN28B HMGA2 GC PTEN UFC1 NKD1 PMC8465902__F5 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer MFN2 FES TF PMC8465902__F4 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer CIAO3 CIAO2B ABCB7 CISD2 CIAO1 CISD1 MMS19 NDOR1 NUBP1 NDP CIAPIN1 PMC1992519__F2 Signaling on the endocytic pathway EGF EEA1 SMAD2 EGFR PMC6941297__F1 Protein expression, molecular pahtways, facilitators and mutations involved in the genesis of brain metastases from melanoma, breast and lung cancer BNC1 BRAF CTSS KEAP1 CXCR4 EGFR RHO CXCL12 MTOR TOP2A GAD1 GALNT9 PMC4186342__F1 Trafficking of TLR4 CD14 TLR4 RAB11A RAB7B RAB10 TMED7 PMC5839936__F2 Proteins significantly altered by torcetrapib associated with aldosterone synthesis or function ANGPT2 BMP6 POMC DKK3 NPPB PYY TGFB1 VIP PMC10779133__F2 Neuroprotective effects of KBs and KD by providing energy source and improving mitochondrial dysfunction in the brain SIRT2 SIRT1 FOXO1 SIRT3 PMC10779133__F1 Ketogenic and ketolytic pathways in the liver and brain cells CS ACAT1 HMGCL BDH1 PMC10779133__F4 Signaling functions of KBs and KD for anti-neuroinflammation and autophagic flux NLRP3 ULK1 TFEB COX1 FOXO3A LAMP2 RHO HCAR2 NR1C1 FOXO1 STAT3 PMC5839936__F3 Proteins significantly altered by torcetrapib associated with insulin sensitivity or pancreatic Beta-cell function PRKCQ MAPK8 MMP2 GHR GSK3A TNFSF12 TGFB1 APOE CD36 FSTL3 PMC10779133__F3 Signaling functions of KBs and KD for anti-apoptosis, antioxidant defense, and epigenetic and post-translational modifications NOX4 BDNF FOXO1 UCP2 PMC4286324__F3 Schematic diagram describing Src regulation by trafficking EHD1 SRC RHOB PMC11846620__F6 Molecular Mechanisms of Immunoinflammatory Infiltration and Ferroptosis in Arthritis Revealed by a Combination of Bioinformatics and Single-Cell Analysis GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 FTMT DKFZp686F0183 F2 HEL-S-64p PCBP1 SLC3A2 CP TF PMC2615463__F1 Arc function in mGluR-LTD EEF2K EEF2 ARC PMC3049852__F1 Multifunctional effects of CMKLR1 activation CMKLR1 SRC SYK MTOR PMC8929637__F2 An illustration of the known proteins involved in glycerolipid synthesis in Apicomplexa parasites ELOC ELOA LPA PMC6292430__F2 Does Axl have potential as a therapeutic target in pancreatic cancer? STAT1 EGFR AXL PMC10037252__F2 Systemic treatment for metastatic colorectal cancer EGFR MTOR IRS1 PMC2676302__F5 Major trends in mRNA expression at 56 days on experimental diets and summary network analysis among genes ACACA PRKAA1 LPIN2 HEL-S-104 GPAM THRSP FADS2 SCD SLC27A1 NR1C2 ACLY PPARG FASN PMC9138678__F1 Brain-Derived Neurotropic Factor in Neurodegenerative Disorders EGF SRC MYD88 MTOR BDNF PMC8230033__F1 Altered Bone Status in Rett Syndrome SFRP4 RUNX2 LRP4 HEL-S-11 LRP5 LRP6 PMC4376959__F2 Sphingolipid metabolism CERS3 LASS1 CERS5 SPHK1 CERK SPHK2 CERS2 CERS6 PMC2817888__F3 ATM/ATR DNA damage response pathway and its downstream effectors leading to either G1/S or G2/M phase arrest ATM CDK2 ATR PMC4286324__F1 Membrane dynamics and the endocytic pathway EHD1 EHD3 RILP PMC4484234__F1 Structures of schweinfurthin B and 3-deoxyschweinfurthin B (3dSB) RAP1A FDPS IPP PMC9793423__F1 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights CNTF CLC CRH LIF OSM PMC4888213__F3 Multiple somatic alterations in components within the same pathways MAP2K4 APC PTEN DKK1 RB1 MTOR DKK2 CDKN2A FAT4 ATM INPP5D ERBB2 AXIN1 CCND1 PMC3262546__F1 The p14-p53-p21 and p16-Rb signaling pathways involved in fibroblast senescence CDK2 MDM2 CDK4 PMC9793423__F5 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights MMP2 LIF MDM2 CCND1 ID1 GATA3 STAT3 PMC2778684__F1 Canonical and non-canonical Wnt signaling pathways ROCK2 DAAM1 APC LRP5 ARHA PMC2915874__F4 Effect of estrogen on endothelium-dependent pathways of vascular relaxation COX1 GC SRC PMC2915874__F3 ER-activated postreceptor mechanisms EGFR SRC HBEGF PMC3516599__F1 Proposed Multicompartmental Degradative Pathway of L-lysineL-Lysine degradation is initiated by either peroxisomal Alpha-deamination (pipecolate pathway) or mitochondrial E-deamination (saccharopine pathway) DHTKD1 PIPOX AASDH AADAT AASS GCDH PMC7518784__F2 Inflammatory induction of the colorectal cancer (CRC) occurrence CXCR1 BRAF IL17A IL22 IL8RB STAT3 PMC5682390__F1 Metabolic pathways for engineering oleaginous yeasts to produce a variety of different compounds CAD FADD PMC4281941__F10 miR-93-directed down-regulation of DAB2 defines a novel oncogenic pathway in lung cancer TP53INP1 ITGB8 CDKN1A AID F3 VEGFA PTEN BCL2L11 SP7 LATS2 PMC2575183__F7 Proposed signaling mechanism that stimulates EMT LEF1 HEL-S-28 GSK3B PMC10558021__F2 Cyclophosphamide metabolic pathway CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC10095465__F1 Apoptotic signaling pathway BAD TRADD MCL1 BMF TNF FADD HRK BAX PMC3093880__F8 miR-122 and liver-related functions and diseases CDA SLC4A3 CS SLC7A1 BCAT2 VPS4A GYS1 GNPDA1 HEL-S-87p FOSL2 MMP7 ARHGAP1 FUT8 MAP1B MAP4 PTPN1 HEL113 CLIC4 PXN PMC9563233__F1 ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway CHEK2 ATM H2AX PMC8807479__F4 Functions and Regulation of Translation Elongation Factors DPH2 DPH5 DPH6 DPH7 DPH3 EEF2 FES DPH1 PMC3093880__F9 Associations among miR-122-identified targets CDA METAP2 FOSL1 CREB1 PAK4 TRIP6 PNN RAC1 FOSL2 CEBPB MMP7 ARHGAP1 SMARCA4 VAMP2 MAP2K1 VAMP3 PTPN1 SLC2A3 HEL113 JUN PXN MYLK PMC6822533__F1 Engineering anti-cancer nanovaccine based on antigen cross-presentation FER RAB11A SEC22B PMC6207917__F6 Mechanism of DQP on cardiac lipid and glucose metabolism ACADL CPT1A GSK3B PMC6053540__F4 Biogenesis of miR-451 AGO2 GC DROSHA PMC5993488__F2B Cumulative HLA class I and APM defects across gliomas from TCGA MHC2TA TAP2 IRF-1 TAPBP PMC3836075__F5 The role of Ang II and its metabolites in the adrenal gland vasculature ACE2 PMC9325158__F1 Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy TH CGAS IRF9 RELB TRAF6 IRF3 IFNAR2 IFNAR1 PMC10142234__F1 Graphical representation of JAK-STAT signaling pathway and therapeutic compounds suppressing it through the inhibition of one or several members of the family TYK2 JAK3 JAK1 PMC2713566__F1 Mitochondrial pathways of electron flow resulting from the substrates and inhibitors used in this study FES CIT MAL PMC8905312__F1 Candida albicans stress response pathways in antifungal tolerance and resistance PMC6262299__F2 Neurotrophic factor (NTFs) signaling pathways CNTF RET BAD NGF GDNF BDNF PMC5891588__F1 Development of NEPC by the SRRM4-mediated RNA splicing network PHF21A SRRM4 FOXA1 PMC8255319__F2 Molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives ME1 HEL-S-32 GFPT1 HMGCR SLC7A5 LDLR SOAT1 RPIA ACLY RPE HEL-S-133P HK2 FASN PMC6146607__F1 Lipogenesis and cholesterol synthesis pathways ACAT1 SCD ACACA ELOVL6 ACLY FASN PMC8198029__F4 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer IKBKG TLR9 EBI3 LY96 HIF1A RIPK2 MTOR IFNG STAT1 IL18 TLR4 MNT CCR7 IL17A IL22 IL2 NOS2 IL4 HMGB1 IL10 IL1A IL13 PTGS2 MMP9 CXCL10 NR3C1 CD44 PARP1 IRF3 TIGIT IL6 TNF TLR1 NR1C1 HEL-S-125m IL15 NFKBIA NFATC2 EP300 NFKB1 RELA PPARG STAT3 PMC8198029__F3 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer MUC1 PML SOCS3 BRAF FOXM1 IL9 ATF2 TGFBR2 MYD88 HIF1A IL12A CDKN2A SOX9 TRPV1 HEL-S-67p IL17A SRC CCND1 IL2 IL4 IRF-1 IL1B F11R HMGB1 PRKCI IL13 PTGS2 VEGFA CD44 IL6 DIABLO HEL-S-22 NFATC2 PRKCB TNFSF10 KLF4 SYK RORA MYLK STAT3 PMC7862565__F24 Molecular signaling pathway TLR4 MYC TNF FADD BAX PMC8198029__F1 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer EREG EGF EPCAM FOXC2 RPTOR IFNG IL18 NR1B3 PSMD10 MSH6 IL22 NOTCH1 THBS1 EZH2 DCC KDM1A RBPJ TCF3 PLAUR AREG RUVBL1 KDM3A APC PTGES ATF3 NRG1 FGF18 MAPK15 TBX21 COPS6 ICMT CDX2 GJA1 ERBB2 IGFBP2 PIK3CA CDX1 TGFA PMC6335273__F4 Three main features (GSIS, beta cell mass and insulin action) and insulin secretion pathway in GK rat GHSR BAD FAM3B PPP1R3E SLC2A2 GCK ABCC8 ADCY3 CACNA1F ADCY9 NR2A2 PMC9650235__F3 IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines? BAD JAK3 JAK1 MCL1 FOXO1 BAX PMC8839962__F1 Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases RS1 PGR INS MTOR IRS1 HEL-S-162eP PMC3794211__F2 MiRNAs implicated in neurodegeneration SNCA LRRK2 TBP HTT APP REST ADAM10 FUS PMC7369905__F4 NRF2 regulates inflammation and immunity IL16 MARCO CD80 TNF PMC7369905__F3 NRF2 regulates metabolism ME1 GCLM HEL-S-30 ENO4 PCK1 SLC7A11 GCLC FBP1 FTL GLS2 ENO1 MTHFD2 HEL-S-26 GPT2 F2 HEL-S-64p ELOVL7 FADS1 HEL-S-44 HEL107 PMC8462294__F2 Progression on the Roles and Mechanisms of Tumor-Infiltrating T Lymphocytes in Patients With Hepatocellular Carcinoma STAT3 FOXP3 PMC4986688__F1A Immune mediators of chronic pelvic pain syndrome IL10 IL13 IFNE CD40 IL6 IL-21 IL4 PMC2689776__F7 Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells IGF1R PMC4654485__F2 Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer AGO1 VHL VEGFA HIF1A MTTP HIF1AN PMC3821857__F7 DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma EGF EGFR PMC5569050__F5 Mechanism of skin dopaminergic sensory modulation PIEZO2 DBH TRPV1 PMC8149214__F5 Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation F2R MTOR PMC6522820__F2 Effect of the PI3K/AKT signaling pathway on gynecological tumors TSC2 PTEN PMC6522820__F1 The PI3K/AKT signaling pathway EGF PTEN PMC2769250__F3A Trafficking of Heme and Porphyrins in Metazoa ABCB6 UROD UROS CPOX PMC11528219__F2 Stomatal development by environmental signaling in Arabidopsis ICE1 HEL-S-11 ERF CA4 PMC8492792__F4 Multiple strategies for inhibiting Hh signal transduction pathway SUFU SMO BRD4 PMC2829367__F1 Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy LEF1 TWIST1 GSK3B CD44 CCND1 PMC8492792__F3 Hh signaling in cancer SUFU PTCH1 GPR161 SMO PMC8492792__F1 Conserved Hh signal transduction pathway KIF7 SUFU SMO SPOP ADRBK1 PMC7857091__F1 Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer CD59 C9 VTN C7 C6 MASP2 CD55 CPN1 CR1 PMC8616011__F3 Immunotherapy in Breast Cancer: When, How, and What Challenges? CCL2 B2M PMC7758290__F1 Complement system CD59 CD46 FH CD55 C1S CR1 CLU PMC3828559__F1 RAS-RAF pathway and immunohistochemical staining of colorectal cancer specimens with BRAF V600E mutation specific monoclonal antibody BRAF EGFR PMC5260505__F6 Proposed function of CDK1 in regulating pluripotency SMAD2 GSK3B CDC2 PMC5362072__F3 Cell-intrinsic effect of STING activation in tumor cellsThe functionality of the STING signaling pathway can be altered in tumors.A) Oncolytic viruses like HPV or adenoviruses drive E7 or E1A oncoprotein expression CGAS RAE1 PMC4831676__F7 Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells ULK1 EIF4EBP3 ATF4 RPS6KA4 EIF2A RPS6KC1 BNIP3L EIF4E BNIP3 RPS6 MTOR PMC4370290__F3 Pathways involved to block cell cycle progression ATM CDK2 CCND1 CDK4 CDC2 CDC25B ATR CDK6 PMC2827616__F8 Signaling pathways controlling ENS precursor migration and lamellipodia formation RET GRB2 SHE GDNF RHO PTEN RAC1 CDC42 PMC4819324__F1 Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis RAP1A FDPS IPP PMC9441940__F1 Multiple myeloma metabolism – a treasure trove of therapeutic targets? SLC1A4 ACSS2 PHGDH PMC11985624__F2 Conceptual representation of potential mechanisms for osteogenic effects of exercise IMPACT SOST MSC IL6 PMC8093649__F6 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases CD40 RAC1 TRAF2 PMC7313746__F4 Signature genes associated with immunological non-responsiveness to anti-retroviral therapy in HIV-1 subtype-c infection GSK3B RPL4 ITGA4 TOMM7 HNRNPA0 ITGB1 CENPK RPS3A RPL39 RPS24 UBC TIMELESS RECQL ITGA6 SATB1 MDM2 RPS15A PMC11985624__F1 Osteocytic changes in sclerostin expression mediate bone mechanotransduction to skeletal loading APC MSC GSK3B PMC8093649__F3 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases TRADD SHARPIN MAP3K7IP1 TRAF2 FADD MLKL PMC7353046__F7 Adams–Oliver Syndrome and Notch signaling RBPJ ARHGAP31 DLL4 DOCK6 PMC7353046__F6 Dowling Degos Diseases and Notch signaling POFUT1 KRT5 PSENEN PMC8615798__F6 Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase MOCS2 MOCS1 MOCS3 GPHN MOCOS PMC8093260__F1 An update on the regulatory mechanisms of NLRP3 inflammasome activation S1PR2 CASR APOC3 TRAF6 MYD88 ZBP1 NLRP3 MFN2 RIPK1 FYN TLR4 TRPM2 IL1B BAX RIPK3 TNF TLR3 C5AR2 LYN SYK TXNIP FADD MLKL MAVS CD36 BRD4 PMC12123091__F4 Key metabolic pathways of proline and hydroxyproline in the cell PYCR2 CLYBL DAO PRODH GLUD1 PMC12123091__F3 Metabolic pathway of hydroxyproline as an initial product for intracellular interconversions and processes GPT PRODH PRODH2 PMC7246457__F5 Network analysis of proteins related to inflammation-driven pathology of ARPE-19 cells PIK3R1 PLCG1 EIF2S1 EGFR MAPK3 GPX1 JAM3 POR HSF1 LPCAT1 CORO1A MTAP SMARCA4 SRC SP1 HEL-S-133P CTH GCLM PRKAA2 HMGA1 HEL-S-102 BCL9L RAF1 SOS1 FADD BCL9 GLS AGFG1 PMC5749905__F1 mTOR signaling pathway and its upstream elements NF1 GSK3B PTEN RHEB TERT PMC4900950__F3 Signaling pathways regulating Müller glia cell dedifferentiation and proliferation following retinal injury in zebrafish ASCL1 SMAD2 INSM1 TGIF1 HBEGF STAT3 PMC3982454__F8 CD44 protein-protein interaction pathways were performed by String 9.0 Web software UBC TSC2 PTMS GSK3B MDM2 CD44 PTEN MTOR FOXO1 TERT PMC2577715__F9 Nrf2 and transcriptional regulation of Gamma-GCSh expression KEAP1 MAFK PMC9524569__F2 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway NLRP3 HMGB1 TLR4 RELA MYD88 STAT3 PMC2577715__F4 NFKB signaling and MDR gene expression RELB CD40 MYD88 PMC9695095__F2 The NLRP3 inflammasome in chronic inflammation in asthma and chronic obstructive pulmonary disease NLRP3 ADAR TRPV4 TLR4 AHR MUC5AC PIR TRPM2 TRPA1 SIRT1 TRPV1 GSDMD PMC3525581__F7 Toxicogenomic Analysis Suggests Chemical-Induced Sexual Dimorphism in the Expression of Metabolic Genes in Zebrafish Liver PMC6025455__F4 Endothelial targeting to boost endogenous antithrombotic and anti-inflammatory pathways PC APC PMC8842666__F6 ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability ASB17 RELA TRAF6 PMC9139376__F6 Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer Cells GK5 MXD1 MAPK9 MAPK8 SMAD2 CDKN3 MAPK14 NRARP SMAD4 TFDP1 E2F3 OSMR CDK6 PLOD2 BMPR2 LMNB2 NOLC1 PERP MMP2 CDK14 COL12A1 SATB1 MDM2 PHLDA3 DKC1 MAPK1 SP1 NOTCH2 AKAP12 MAP3K1 ANKRD45 CDKN1B CDK15 COL27A1 SLC20A1 NINJ1 IL10RB TSC2 PPP3R1 CDKN1A CDC6 SMURF2 TGFA MYLK CUL5 ITPR2 EGF ROCK1 CTCF TGFBR2 IL1R1 GAS1 PTEN MTOR CCND2 NOG PTPN11 COL1A2 CCND1 CDK4 CDC2 PFKP KLF6 NCOR2 RBL1 DKK3 BMP2 SMAD6 SKP1 HEL-S-87p CAB39 SMURF1 HDAC1 AURKA VLDLR CREBBP PSEN1 TP53INP2 PITPNC1 CDK5R1 MCL1 DKFZp781O1323 COL4A2 COL4A1 STAT3 PMC5146659__F5 Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta CCND1 PKD1 MTOR RHEB PMC6186122__F3 Schematic of the extrinsic and intrinsic coagulation cascade PC TFPI F2 APC F11 TF PMC6153639__F1 Folate structure and metabolic pathway DHFR FPGS DHPS NDP PMC8534845__F1 Immunotherapy in Extensive-Stage Small Cell Lung Cancer ASCL1 SLFN11 CXCL10 MYC CCL5 DLL3 RB1 AURKA WEE1 ATM NEUROD1 EZH2 ATR PMC5435901__F3 Curcumin plays a protective role at the priming and the activation stage of renal fibrosis CCR7 SPHK1 JUN NEDD4 PMC8692700__F2 Functional role of Pescadillo ribosomal biogenesis factor 1 in cancer PES1 GSK3B PTEN AXIN2 HIF1A TCF4 BRD4 PMC2413058__F7 Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor EGFR CBL PMC6952538__F3 Intermediates of the cholesterol biosynthetic pathway function as RORGagonists SQLE CYP46A1 EBP SC5D DHCR24 HMGCS1 HSD17B7 TM7SF2 CYP51A1 HMGCR CYP7A1 CH25H ACAT1 DHCR7 FDFT1 PMC3781481__F2 Classic and alternative lipogenic pathways of fructose AMPD2 ACO2 KHK TG PMC1601944__F1 HIF-dependent VHL pathways in oncogenesis EPO EGFR VHL TGFA PMC6588196__F1 Possible sex effects on aspects of the CR/Met R mechanistic pathways FGF21 IGF1 MTOR PMC7934455__AF1 lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/Beta-Catenin Pathway and Oncogenic Autophagy ATG12 CUL4A PMC9410805__F7 Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2 MAF PC KEAP1 RBX1 BACH1 PMC8572421__F1 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment LPL HMGCR FASN CD36 PMC8303588__F2 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment GRB2 ARHA MTOR PMC5595361__F1 Signaling pathways involved in GBM-induced apoptosis TNF BAX PMC3417337__F1 Platinum drug action pathway MPO CCNH XPC SLC31A1 NQO1 HEL-S-22 ATP7B RRM1 ATP7A MDM2 CCND1 ERCC5 ERCC1 XPA ABCG2 ABCC2 ABCB1 PMC8303588__F1 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment SMAD2 SMAD4 PMC8572421__F3 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment MSR1 TGFBR1 IL8RB MTOR ARG1 NR1C1 FASN STAT3 CD36 FOXP3 PMC2575467__F5 A model of KCNQ1/KCNE1 function in embryogenesis SOX10 KCNE1 PMC6990114__F3 Hippo pathway plays vital role in mammalian immune system TBK1 CGAS FOXO3A DOCK8 IRF3 RAC1 FOXO1 RAB13 FOXP3 PMC5595361__F4 Interrelationships between programmed cell death TRADD TRAF6 IRF3 MYD88 MTOR FADD PMC6770252__F3 Biological origin of free radicals and their effect on cell viability ATF4 NOX4 XBP1 BAX PMC6770252__F2 Three major branches of the Unfolded Protein Response (UPR) signaling pathway and their interconnections ATF4 EIF2A TRAF2 XBP1 PMC6171904__F1 miR-451-AMPK-mTOR-cell cycle signaling pathway TSC2 TSC1 CDKN2B CDKN2D CAB39 MTOR PMC9257764__F5 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) LEP LEPR STAT3 PMC9257764__F4 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) INS FOXO1 PMC12174925__F3 Dual Role of Autophagy in Periodontal Tissue under Periodontal Pathogen Infection and Diabetes Environment HGF ATG12 ATP6V0C MTOR IL1B PMC9281521__F5 Preliminary Study on Gene Regulation and its Pathways in Chinese Holstein Cows with Clinical Mastitis Caused by Staphylococcus Aureus HEL-S-302 TH PLCB3 VASP SEPSECS AHCYL2 MAPK14 AASS MTM1 GPAM ITGA2 XYLB HGSNAT HEL-S-111 HEL-S-70p GLA HK2 ALG11 CTH ABO ABAT GNAS DEGS1 MYLK GLS PMC6365498__F8 IPKB analysis of relationships among upregulated genes on silk film topography NUMB PRKCE HEY2 FLNA PSEN1 DTX2 JAG2 NOTCH1 PPP2R1A FLNB CRK STAT3 PMC6193676__F1 Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast DPH5 DPH6 DPH7 DPH1 PMC10298365__F5 Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis IL6 TNF IL1B PMC3514292__F1 Schematic representation depicting A; the protein synthesis pathway in skeletal muscle involving the mammalian target of rapamycin complex 1 (mTORC1) TSC2 TSC1 IGF1 FOXO3A MTOR EIF4B IRS1 SIRT1 FOXO1 RHEB PMC4526643__F2 Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model BAK1 CD2 NFE2L2 SATB1 GRAP2 DDT PTP4A3 CP ACOX1 PMC6952538__F1 RORGt functions play a central intermediary role in linking the control of cholesterol biosynthesis and metabolism to the regulation of immune responses and autoimmune disease NCOR1 AHR NCOA1 HDAC1 PMC5916931__F4 Dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? GCGR COX2 GC CD34 PMC6741141__F5 Metabolic pathway of aerial and submerged mycelia in the liquid surface culture of Cordyceps militaris PDC CPO HEL-S-162eP PMC4810089__F3 ARE- and GRE-signaling pathways stimulated through growth factors and growth hormones FOS RGS4 CSK MYC PTEN RGS2 EIF4E MTOR CEBPB FYN WEE1 KSR1 GRB2 SRC CDK4 SP1 GRB10 JUN RGS10 PMC11542495__F2 Cytoprotective Mechanisms of HO-1: Heme oxygenase 1 is an enzyme responsible for the breakdown of heme into Fe²⁺, CO, and bilirubin, which is subsequently converted to bilirubin by BVR KEAP1 FBXO22 BACH1 PMC4810089__F2 Kinase signaling pathways involved in T cell receptor activation PLCG1 SOCS3 TEC PTEN MTOR CEBPB ITK FYN BCL10 F3 RUNX3 RUNX1 FOXO3A CSK FOS CEBPA RAC1 FOXO1 CBL LCK ZAP70 GRB2 SHB JAK1 LAT PMC11542495__F1 Schematic diagram of Nrf2 and Keap1 domain structure: Nrf2, is a transcription factor characterized by multiple functional domains, including Neh2, Neh4, Neh5, Neh6, Neh7, Neh1, and Neh3 KEAP1 RXRA PMC7390945__F4 Some involved pathways in C8- and C10-treated cells, on the basis of Metabolic Pathway analysis ACLY GLS PMC6089198__F8 Mutation frequency of selected pathways CTBP2 RNF43 APC WNK1 PTEN CASP3 TAP2 HLA-DRB5 CHD8 AXIN1 PIK3CA B2M CASP8 BAX PMC7854758__F11 On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model PTH CR2 PMC3827695__F4 Women and Lung Cancer: What’s New? EGFR GRB2 STAT3 PMC3057165__F1 Pathways by which toll-like-receptor signals and ligation of FcG receptor lead to the production of interleukin TRAF6 SYK MYD88 PMC2770656__F4 The tyrosine metabolism pathway where the differentially expressed genes of lung cancer were annotated HIST1H1E DDT PMC9552026__F5 Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review) RUNX2 TRPM6 TRPM7 PMC8774087__F1 Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19 BAD ACE2 ADAM17 PMC11542495__F3 Regulatory mechanisms for Nrf2/HO-1 signaling pathway: Under normal conditions, Keap1 mediates the ubiquitination and proteasomal degradation of Nrf2 by binding to Nrf2 and interacting with the CUL3 ubiquitin ligase complex MAF GPX4 KEAP1 JUN NQO1 PMC7317223__F4 Cell cycle and signalling pathway cascades in the Chinese ESCC subtypes CCNA2 PLK1 TGFBR1 APC TGFBR2 MYC SMAD4 HCTP4 AURKA PRC1 CDK2 NCAPG AXIN1 CCNB1 CCND1 KIF20A CDK4 MKI67 SKP2 PMC10573125__F1 The JAK-STAT signaling pathway by LNK in hormone receptor-positive breast cancer and non-tumor cells PIM1 PRLR CCND1 IL6R PRL STAT3 PMC4853852__F5 Genes under multiple regulatory controls in the PTEN pathway PIK3CD PIK3R1 PRKCZ IKBKG BAD TGFBR1 TGFBR2 FGFR4 PTEN ITGA4 TNFRSF11A MAGI3 FGFR2 ITGA2 INSR TNFSF6 BMPR2 FGFR1 MAST2 TGFBR3 NTRK2 FGFRL1 CNKSR3 MAGIX FGFR3 GSK3A RRAS CBL PREX2 CASP3 SYNJ1 CDKN1A BCL2 RAF1 IGF2R AKT3 PMC8267719__F3 Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions PTEN MTOR FOXO1 PMC7485347__F3 Functional and clinical significance of INI‐1/SMARCB1 CCND1 PMC3581421__F8 Coupling and S1P signaling in mesenchymal cells S1PR2 S1PR1 SPHK1 PMC4357835__F2 KEGG pathway analysis HEL-S-62p F10 F2R PLAUR TFPI F8 PROC C4A CD59 PLAT F2 F3 VWF C6 PMC524335__F7 Regulation of angiogenesis by the ancillary receptor endoglin SMAD2 SMAD1 DKFZp781O1323 PMC4674888__F12 LRRK2 in neurons in Parkinson's disease which is the fifth scored pathway map in MetaCore enrichment analysis results HEL70 LRRK2 AP2A1 AP2A2 GSK3B RDX PMC8490651__F6 Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19 COX2 NEDD4 PMC4674888__F10 Cell cycle Role of SCF complex in cell cycle regulation which is the third scored pathway map in MetaCore enrichment analysis results PLK1 ATM APC SKP1 CDK4 ATR RBX1 CDC34 SKP2 PMC2967529__F8 Model for vertebrate limb induction and outgrowth FGF10 FGF8 TBX5 PDLIM7 FGFR2 PMC6164894__F2 Canonical TGFB1 signaling pathway SMAD2 SMAD4 TGFB1 PMC10551897__F9 SX Components-top 8 Targets-Pathways Network (Green hexagon node shows SX, pink circle nodes show the components, purple rectangle nodes show target genes, orange V-shape nodes show pathways and edges show the interaction between two nodes) EP300 ERBB2 EGFR SRC STAT3 PMC10551897__F8 SX Components-Targets-Pathways Network (Green hexagon node shows SX, pink diamond nodes show the components, blue rectangle nodes show target genes, orange ellipse-shape nodes show pathways and edges show the interaction between two nodes) KIT PRKCE PLK1 PTGS2 FGF2 EGFR PTGER4 CDC25B MTOR AURKA PRKCA CASP3 CSF1R FLT1 KDR EP300 ERBB2 CDK2 MDM2 SRC CDC2 PTPN6 FLT3 CASP8 PMC11706781__F1 Angiogenic cascade and metabolic reprogramming of ECs in tumorigenesis CPT1A PSAT1 ASNS NOTCH1 PHGDH FASN PMC3009898__F6 Model for an alternative Okazaki fragment-processing pathway in vivo FEN1 LIG1 DNA2 PIF1 PMC8533981__F5 Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer CCND1 MTOR BAX PMC11706781__F3 Interactions between immune cells and tumor endothelial cells in the tumor microenvironment CPT1A ASNS VEGFA TEC FASN PMC1993906__F16 Adenylyl cyclases are targets of multiple regulatory signaling pathways and respond differently, depending on which group they belong to PLCB4 PLCB2 PLCB3 SRC RHO PLCB1 CDC42 PMC1993906__F13 The G12/13 signaling pathway BTK TEC PMC6595688__F1 PKM2: Junction of Metabolic Networks and Signal Cascades TH F2 CIT MAL PMC514949__F9 Multiple pathways involved in tumorigenesis by VEGF-null tumor cells PC PMC7676225__F6 Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels TSC2 TSC1 APC GSK3B TBC1D7 MTOR RHEB PMC7311749__F1 Multiple oxidative stress factors induce pneumonia and AMPK-Nrf2 pathway inhibits pulmonary ROS accumulation FOXO3A NQO1 UCP2 PMC3706521__F3 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation CD14 BAD EGFR DIABLO HEL-S-69p PAK1 IGF1 GAB2 IL3 RELA GRB2 LBP IL4 SP1 JUN TERT PMC8393955__F6 Implications of a ‘Third Signal’ in NK Cells RORC CCR5 CCR3 EBI3 CXCL10 CCR4 TRAF6 IRAK4 MYD88 TNF IL23R MAP3K7IP1 IL12RB1 STAT4 CXCL9 TYK2 JAK1 RORA PMC3364930__F5 Subcellular localization of components of the PIWI-piRNA pathway and the proposed mechanism of TE suppression by this pathway MAEL HEL25 TDRD1 DNMT3L HIG-1 MOV10L1 PMC3706521__F4 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation CD47 KDR NGF MMP9 GRB2 VEGFA TGFA CDC42 CD36 PMC4955761__F8 Pulmonary Epithelial Toll-like Receptor 4 Activation leads to Lung Injury in Neonatal Necrotizing Enterocolitis HMGB1 TLR4 CXCL5 PMC10502204__F2 ctDNA as a novel and promising approach for cancer diagnosis: a focus on hepatocellular carcinoma RPL11 ATM APC LRP5 MDM2 LRP6 RPL13 RPS7 ATR RPL5 TERT PMC5434066__F8 Schematic diagram of Bc-specific induction of regulatory T cells via suppression of mTOR signaling pathway SGK1 GATA3 STAT3 FOXP3 PMC8047446__EV5 GOLPH3‐driven functional enzyme module CTRL GOLPH3 PMC4198693__F5 Identification of molecular pathways that are altered by Atbf1 inactivation in mouse prostates ZFHX3 ENPEP EHF NR3C1 FGF18 SLC22A4 ABHD2 GAA LAMA3 TACSTD2 HEL57 RARRES1 AHR IKZF4 GPT2 ASNS MCM10 NR1H3 GGCT MCOLN2 PMC4066335__F3 All diabetes drugs are likely to have indirect effects in the CNS by affecting circulating concentrations of glucose and insulin IRS1 STAT3 PMC5893801__F1 Therapeutic strategies to enhance immune checkpoint inhibitors by targeting tumor-associated macrophages (TAM) CSF1R MARCO CD80 ARG1 PMC5927721__F1 MiRNAs targeting the IGF1R pathway in its entirety TSC2 BAD TSC1 GSK3B GRB2 SHE FOXO1 PMC5711834__F16 Schematic model of the Keap1/Nrf2 signaling pathway MAF KEAP1 PMC6592248__F8 Proposed model to explain the molecular mechanism of Bmal1 deficiency influenced the HIF1Alpha-VEGF axis in the chondrocytes CRY1 PC PMC8920499__F1 Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma SUFU PTCH1 GLI3 MYC VEGFA SHH CCND1 BCL2 SMO PMC5850311__F1 Research and therapeutics—traditional and emerging therapies in systemic lupus erythematosus CD22 CD40 CD80 PMC6652233__F3 Stimulation of TLRs activates multiple signaling pathways CD14 TLR5 TLR4 TRAF6 IRF3 MYD88 TLR3 PMC9524569__F1 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway CNTF EGF IL6 TNF TGFA IL1B PMC7281705__F3 Ang1 and Ang2 bind to Tie2 with similar affinities; however, whereas Ang1 is an agonist, the ability of Ang2 to activate Tie2 appears to depend on the cell type and context EGF PAK1 SCD GRB2 ARHA RAC1 GRB7 PMC7676225__F1 Metabolic effect of Wnt promotes the absorption of glucose in the neuron by increasing the affinity of the GLUT3 transporter for its substrate TSC2 TSC1 APC GSK3B TBC1D7 MTOR RHEB PMC6437932__F8 Working model WTAP BNIP3 PMC10380571__F2 Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies RNF168 ATM CDK2 ATRIP CDK4 ATR CDK6 PMC8353884__F7 Proposed Model of IKK:NFKB:Notch Signaling Control by SLX4IP and RAP1 RBPJ HEY2 SLX4 PIAS1 SLX4IP TERT HES1 PMC7175209__F1 Induction and initiation of cellular growth control and senescence via p53 or P16INK4A pathways ATM CDK4 ATR CDK6 PMC6683960__F1 Gold nanoparticles-loaded hydroxyapatite composites guide osteogenic differentiation of human mesenchymal stem cells through Wnt/Beta-catenin signaling pathway RUNX2 APC GSK3B PMC9531660__F3 Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats PML SOCS3 TRAF3 CCND3 CDK6 IFNG RNASEL RNASE1 IL18 TLR7 TLR4 CASP9 CDK4 IL1B BAX PLG IRF7 NLRX1 IRF3 IL6 TRIM25 TLR3 ADAR CASP3 NUP98 FADD PMC7663720__F2 Pharmacological inhibitors targeting the Wnt pathway that are currently being tested for cancer treatment APC LRP5 LRP6 BCL9 PMC7663720__F1 Wnt signaling pathway ATF2 APC LRP5 LRP6 ROR2 RHO BCL9 JUN ROR1 CDC42 PMC7226210__F2 The most relevant molecular pathways and targeted agents in TNBC TSC2 TSC1 GRB2 PTEN IRS1 BRCA1 PMC6271057__F5 GSK3B and phospho-GSK3B regulate milk synthesis and DCMEC proliferation via the mTOR/S6K1 signaling pathway SCD CCND1 MTOR PRL PMC9280125__F1 Homocysteine Metabolism in Pregnancy and Developmental Impacts HEL-S-61p DHFR PMC11932845__F1 FGF/FGFR signalling pathway in mammary epithelium and TNBC GRB7 PMC10242111__F4 Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations SOCS2 IL13 CSF3R MYC BCL2L1 MTOR STAT5B GHR BCL2 PTPN6 RAF1 JAK1 MCL1 MPL SOCS1 STAT3 PMC6358786__F4 Alterations of the PI3K/Akt-Cyclin D1 pathway in cell cycle progression from G1 to S phase in 2-cell embryos ATM CDKN1B CEND1 GSK3B CCND1 CDK4 PTEN SDK2 CDK6 CCNE1 PMC9288709__F5 Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing BAD CD37 MEI1 MYC PTEN RAC1 EIF4E TSC2 TSC1 BCR MDM2 GRB2 SYK RBL2 CD19 PMC8246550__F3 Epigenetic regulation of cancer stem cell formation and maintenance TDG TET3 DROSHA F11 EZH2 ME3 TF TET2 TET1 PMC4114568__F4 PleiotRHOpic PTK7 ARHA RAC1 RIC8A RHOU RET PAK1 EDNRB PHACTR4 CXCR4 GDNF TRIO CDC42 PMC7403980__F7 Mechanistic scheme of anti-inflammatory signaling pathways of KMU-470 NLRP3 COX2 TLR4 MYD88 IL1B PMC6458768__F1 CD22 structure and signaling pathway BCR CD22 PMC6502913__F7 USP7 functions in several canonical signaling pathways NOTCH1 PMC3040416__F3 Proteins oxidized by extracellular EhCySS control cell signaling and morphology DYNC1H1 MYH9 RPS4X MAP2 MYO1C POSTN ATP1B1 EEF1A1 RPL4 RPS16 EEF1G ATP6V1E1 RPL11 RPS17 NDUFS1 CKAP4 SPTBN1 VCP SDHA SLC5A3 PMC6284331__F1 Effect of changes in ECM‐mediated signalling pathways CD44 UNK SRC RHO DDR2 PMC4107774__F1 The Hippo signalling core cassette in mammals LATS1 LATS2 PMC8396993__F1 Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations—NOTCH1, SF3B1, MYD88, BIRC3 CDKN1A DLL4 JAG2 MYC NRARP ADAM10 DLL3 PMC3083963__F1 Brain-derived neurotrophic factor (BDNF) gene and stimulated intracellular signaling cascades after activation of tropomyosin-related kinase (Trk)B GRB2 SHE BDNF PMC8394001__F3 Guardians of the Genome: BRCA2 and Its Partners PALB2 FBXO18 FANCD2 VHL MRE11A BRCA1 POLD3 BRCA2 PRIMPOL HLTF SMARCAL1 RAD51 FANCA DNA2 PMC10840523__F1 Therapeutic Potential of Fingolimod in Diabetes Mellitus and Its Chronic Complications S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 PMC11978054__F11 Impact of hydroxyurea and metformin on Gamma-globin induction involves complex molecular pathways MYB NFE2 BAD IGF2BP1 MAFF FOXO3A HDAC1 GATA1 KLF4 MAPK1 SP1 LMO2 KLF1 GCNT2 PMC3437205__F3 Pathway analysis of the hypermethylated genes in lymph node metastasis including their biological processes and association to breast carcinogenesis and neoplasm metastasis BMP6 APC CDKN2A BRCA1 PMC9603382__F1 Pathogenesis of Port-Wine Stains: Directions for Future Therapies ANGPT2 PLCB3 VEGFA MTOR PMC3748765__F1 TCDD-induced CTLA-4 on AhR-Treg activating the tolerogenic IDO pathway and suppressing the acute GVH response STAT1 AHR CD80 IFNG PMC7840460__F7 Dmrt1 repressing immune response but promoting proliferation of mGSCs TLR4 TRAF3 CCND1 TRAF6 IRF3 DMRT1 TNF PMC8964056__F4 Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling DAAM1 ARHA ROR2 RAC1 ROR1 PMC10308077__F2 Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective CCR5 FGF21 ANGPTL3 ACVR1 UCP1 EBP CD44 GPR19 LPL FNDC4 PPARG SIRT1 GPNMB PMC4810646__F1 OAS-RNase L pathway RNASEL STAT1 ISG15 IFIT2 STAT2 TYK2 IFNAR2 JAK1 IFNAR1 IFIT1 PMC8251975__F3 Wnt/B‐catenin signaling: Structure, assembly and endocytosis of the signalosome TSG101 PAK1 EEA1 CDC42 PMC4294682__F6 Proposed model of hPer2 and hp53 interaction and function SFN MDM2 BAX PMC9038718__F7 Mechanism by which LINC00858 affects colon cancer PCNP STAT3 PMC4736325__F2 Synaptic binding partners and signaling pathways of BAI adhesion-GPCRs TIAM1 C1QL3 HBD MDM2 C1QL1 C1QL4 C1QL2 RHO RAC1 PMC11554578__F2 Exemplary Ca2+ signaling microdomains RYR1 RYR3 RYR2 ORAI1 TRPM7 STIM1 PMC3675375__F1 Wnt signaling pathway in diabetes mellitus APC LRP5 LRP6 PMC4266039__F7 Biological activities of triterpenoids and saponins in animals CXCL1 CXCR4 MMP9 EGFR BCL2 STAT3 PMC3543845__F2 Top network, “DNA Replication, Recombination, and Repair, Gene Expression, Cancer”, formed by genes exhibiting altered expression in MLT-pretreated MCF-7 cells upon MMS exposure relative to untreated MMS-exposed cells ZNF264 INTS2 HEL-S-128m ZNF805 THEM5 WRN GTF2IRD2B SPAG5 PARP11 C2CD2 CCNB2 CR2 CEP63 DYNLL2 TRAPPC1 PMC9540430__F8 Transcriptomics for child and adolescent tuberculosis FITM1 IRF9 IFITM2 IFNGR2 IFITM1 MX1 IFNG ISG15 OAS1 MED14 AGA RELA TYK2 IFNGR1 IFIT1 BAX PMC7033203__F2 Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis MVD AGA MVK IPP PMC5297991__F3 Functional analysis of the network containing validated segregating variants TYK2 JAK1 PMC4215617__F3 MAPKs in the DAMP perception in innate immune cells TLR4 NRIP3 MYD88 TF PMC9682695__F1 Early postnatal alterations in follicular stress response and survival in a mouse model of Classic Galactosemia ATF4 HEL-S-19 PMC11215075__F5 Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation PC FADS2 ACSL1 TG PEMT PMC3586350__F8 Proposed Adipose Stromal Cell-derived IL-6 signaling pathway TYK2 JAK1 STAT3 PMC6175696__F5 CA biosynthetic pathway starting from C3 and C5 precursors HEL-S-62p CAD PAH PMC8704776__F2 Telomeres and Cancer CTC1 NHP2 TPP1 NOP10 SRSF11 PMC4813474__F10 Proposed model of the p8-regulated autophagy signaling pathway in response to palmitic acid stress ATF4 EIF2A PMC3143721__F5 Putative crosstalk between D1and TrkB receptors in striatal direct pathway neurons controlling PPD mRNA expression AMPH RAF1 BDNF PMC4126105__F1 Proposed integrated model for tissue-type plasminogen activator (tPA)- and plasminogen (Plgn)-mediated modulation of blood–brain barrier (BBB) permeability during thrombolysis in ischemic stroke CCR2 PDGFRA LDLR PIGN PMC8458751__F7 Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis LIPA POR CIT BAX PMC6966475__F3 EMT inducers from the chronic tumor microenvironment and EMT repressors from natural anti-inflammatory compounds and pro-resolving lipids HMGB1 EGF GSK3B GRB2 LTB GPR32 TRAF6 CDH2 SIRT1 STAT3 PMC3921497__F4 Chitinase 3-like 1-associated Beta-catenin activation signaling pathway, which is inhibited by methylxanthine derivatives TBP CCND1 PMC3392648__F1 Insulin signaling pathways BAD GSK3B GRB2 PTEN INSR PMC3025702__F2 Combination Treatment with Progesterone and Vitamin D Hormone May Be More Effective than Monotherapy for Nervous System Injury and Disease BAD NGF BDNF PMC9388302__F2 Essential Role of FoxO1 in the Regulation of Macrophage Function PML SIRT6 SIRT1 FOXO1 PMC9530868__F7 Ubiquitin‐specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma APC USP28 CCND1 TCF7L2 FBXW7 PMC11126050__F7 KIT structure and signalling KIT MTOR TK1 PMC5489693__F7 Gene interaction network related to lipid metabolism of DEGs between WC and WRR chickens MYPN CLIP2 HIVEP2 CPT1A ASXL2 LPL DAP SLC27A1 ZFAND5 ABCA1 CCDC50 PMC6405884__F3 Schematics shown miRNAs which might regulate mGluR/mTOR/LTD signaling PTEN MTOR RHEB PMC6156597__F13 Mapping of the DE genes exclusive to the oval morphotype on KEGG metabolic pathways– PML SEL1L DNER ATP6 SVIP AIRE SELL APOB RET ATF4 REL BAX BAP1 PMC3281623__F9 Toxoplasma acquires fatty acids through a complex network of synthesis and uptake ELOC ELOA DES PMC8744729__F2 Ribosomal Protein S6: A Potential Therapeutic Target against Cancer? PLCG1 AKR1B10 ULK1 PLK1 PIM2 GRPR GSK3B MYC AKR1C1 PTEN STK33 CDK6 HAP1 RPL11 PLD2 ATM MAP4K3 EIF2A EIF3B DRAM1 MDM2 CDK4 HEL-S-70p CDH2 RPS6 SOX2 VHL CDK5 CAB39 AKR1C2 DDIT4 RHEB EIF3C TSC2 LCMT1 TSC1 CDK2 PPM1D SIRT1 PCNA RB1CC1 STAT3 PMC7864206__F1 Essential molecules of the mammalian Hedgehog signaling pathway and their interactions DISP1 SUFU PTCH1 GLI3 SMO PMC4003416__F2 Targets of Twist proteins in the DNA damage response pathway ATM MYC MDM2 ATR BAX PMC1502028__F4 EGFR and mTOR signaling network, and signaling mediator effects associated with rapamycin and/or EKI-785 treatments TSC1 EGFR PTEN EIF4E MTOR STAT3 PMC8004491__F1 Two pathways that collect and deliver axonal cargo for degradation in lysosomes ATG16L1 ATG12 DKFZp686F0183 PMC6156597__F14 Mapping of the DE genes exclusive to the oval morphotype on the SNARE interactions in vesicular transport pathway issued from the KEGG metabolic pathway– STX7 STX6 STX18 VAMP4 STX2 SNAP29 ST14 SNAP23 BET1 USE1 STS STX4A STX11 STX16 STX3A STX8 SYP VAMP7 PMC7595202__F6 Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma EIF4E HIF1A IRS1 PMC7230310__F6 Knockout of IRF7 Highlights its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken TBK1 STAT1 IL18 STAT2 IRF7 TRAF6 JAK1 CPSF4 MX1 PMC5842190__F5 Proposed pathway for regulation of endothelial cell signaling by breast cancer cell-derived EVs and a function-blocking CD47 antibody SIRPA CD47 PMC3193436__F1 Model describing the proposed role of Rap1GAP in the control of GDNF-induced Ret signaling TIAM1 DOK4 RET GDNF RAC1 RAP1GAP CDC42 VAV2 PMC5811339__F1 Hydrolytic enzymes tested in this study participate in sphingolipid metabolism in the lysosome as indicated by their respective gene names (blue) GLB1 GLA PMC4304881__F5 Summary of results of RPPA analysis of EGFR signaling in MCF‐10A + EGF, MCF‐10A + AREG and SUM‐149 cells MOS AREG HEL-S-28 EGFR APC GSK3B NRAS PTEN DKK1 MTOR HRAS ITGB1 RHEB TSC2 RICTOR TSC1 GAB2 GRB2 SRC STAT3 FASN PMC5864190__F1 Models of RIPK1 regulation by IKKA/B and MK2 phosphorylation RIPK1 TLR4 TNF PMC3733802__F2 Prioritizing Disease Candidate Proteins in Cardiomyopathy-Specific Protein-Protein Interaction Networks Based on “Guilt by Association” Analysis PLN DAO MYL2 MYL3 DMD PMC4402072__F5 Schematic model of AREG in the Warburg effect and tumorigenesis AREG EGFR MLX PMC8327086__F8 Berberine Reduces AB42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress BACE1 ELF2 GSK3B APP TG PMC8469852__F3 Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders AIP AHR PMC6941108__F3 Visualization of lncRNAs and mRNAs in enriched pathways CDCA5 MHC2TA KIF23 SOCS3 PLK1 CENPF CXCL8 TOP2A CD74 E2F2 RRM2 KNTC2 CCNB1 CD209 ESCO2 MCM10 CDC2 GINS2 FGL2 AIM2 PTTG1 CCNE2 HLA-DPA1 GM2A MYBL2 HCTP4 IFI27 CDC45 TK1 UBE2C HLA-DPB1 CDC20 HMMR CDC6 BUB1B NCAPG NEK2 TYMS KIF20A HJURP CD80 NCF1 PMC5364818__F2 Canonical and Noncanonical Inflammasome STAT1 NLRP3 TLR4 MYD88 FADD PMC9688488__F4 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases MMP3 MMP10 MMP7 MMP2 RUNX2 MMP11 TIMP3 MMP9 EMCN MTOR PMC12162297__F1 Mechanisms by which a high-fat diet (HFD) affects hematopoietic stem cells (HSCs) TLR4 SMAD2 TGFBR1 NOTCH1 PMC9688488__F1 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases IL33 NOTCH1 STAT3 PMC12162297__F2 High-fat diet (HFD) and energy-restricted diet modulate the function of hematopoietic stem cells (HSCs) TSC1 IGF1 SZT2 PMC8238937__F1 MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis TLR5 TLR9 IRAK1 CXCL8 IRAK4 IL6 CCL2 MYD88 TNF TLR1 TLR3 STAT1 TLR7 TLR4 CD80 PMC7791172__F1 NOD2 regulates AMP A‐defensins expression and AMPs sorting in PCs LRRK2 FGFR3 RELB REL RAB2A NOD2 FGF9 PMC4710177__F2 Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications ATM MDM2 ATR PMC3255869__F1 TLR4 signaling pathway CD14 TLR4 MYD88 TIRAP PMC8774788__F5 Metformin Affects the Transcriptomic Profile of Chicken Ovarian Cancer Cells ANGPT2 RSAD2 HGF FOS FABP6 GCN1 TK1 MADCAM1 MMP7 NFKB1 AID TNFSF10 STAT3 PMC10384366__F11 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells TCF3 KLF4 SOX9 PMC7785807__F4 miRNA expression on cellular connectivity and activities with different Toll-like receptor regulation and molecular function of the cellular signaling pathways (A) TBK1 CD14 TLR5 CTSK CCR3 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 CPO TLR8 IL16 TLR7 LBP IL4 FADD TIRAP PMC6614373__F3 Signaling crosstalk at receptors and adaptors STAT1 CD14 TLR4 MYD88 JAK1 SOCS1 TIRAP PMC6614373__F2 NFKB signaling pathway TLR9 TRADD IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR3 TLR4 TRAF5 TRAF2 TIRAP TAB3 PMC6614373__F1 Pathogen-Responsive NFKB STAT1 CD14 TLR4 MYD88 JAK1 IFNG PMC8981087__F2 Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases BAK1 CD44 ROS1 BAX PMC8116828__F1 Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis LEP KY opn SPP2 TNF SPNS2 PHB2 PMC5851872__F1 Molecular Regulation of Follicle-Stimulating Hormone Synthesis, Secretion and Action GNRHR EGR1 SF1 ATF3 PMC7982593__F7 Graph abstract HCC manifestation is typically preceded by hepatic fibrosis and cirrhosis SMAD2 MYC SMAD4 LATS2 PMC12036158__F3 Regulation of epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF) by ferroptosis GPX4 SLC7A11 SLC3A2 TGFBI BACH1 PMC12036158__F2 Regulatory pathways of ferroptosis LPCAT3 FACL4 SLC7A11 DPP4 SLC3A2 POR DHODH PMC9570383__F2 Metabolic Reprogramming in Tumor Endothelial Cells OXCT1 CPT1A PSAT1 F2 ASNS TEC PHGDH HK2 GLS PMC7911352__F2 Cyst(e)ine-glutathione-GPX4 axis regulates ferroptosis HEL-S-26 HEL-S-89n GPX4 SLC7A11 ATF4 SEPHS2 HEL-S-64p BAP1 PMC6337248__F1 Intracellular signaling pathways that regulate Nrf2 MAF KEAP1 PMC7911352__F4 Other metabolic pathways that regulate ferroptosis GPX4 SLC38A5 FOXM1 SQSTM1 GLS2 VDAC3 NEDD4 PMC3694431__F5 Interaction networks of significantly regulated genes from interconnected neurons 7 days post-infarct GNB2 FBLN2 EZR GPAM DLG4 PDYN GIPC2 TIMP3 HTT NOTCH1 KLK6 EZH2 SP1 KHDRBS2 APOE ACTR2 NELL1 AIP SH3GLB1 ADFP LMNA BCAN ZHX1 HLA-C DKFZp686P0251 VAMP2 GNAI3 GNB1 NEFL GNB4 SEMA4B EIF5B NEF3 NEFH NME2 AQP4 GNAI1 FEN1 ELAVL1 GREM1 RGS5 OMD RIN2 GNG11 RRAS CGA SMURF1 TRIM54 BMPR1A ATN1 SOCS5 PXN INHBB SKP2 KDM6B PMC4087127__F2 Scheme of ErbB dimers related MAPK and PI3K pathway activation EGF HRG ERBB2 ERBB3 RPS6 MTOR PMC9143262__F2 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? PDGFD PDGFC PMC3567829__F9 miR-486 sustains NFKB activity by disrupting multiple NFKB-negative feedback loops TRADD CYLD MAP3K7IP1 ITCH PMC11153983__F6 Illustration of the mechanism of DHA inhibiting T-ALL cell viability, inducing ferroptosis by modulating the SLC7A11-GPX4 signaling pathway and provoking ER stress GPX4 SLC7A11 ATF4 SLC3A2 PMC9143262__F4 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? STAT1 FOXO4 CASR HEL-S-11 CCND1 MTOR ORAI1 STIM1 STAT3 PMC2951227__F7 Hypothetical model for Rad18-dependent activation of the FA pathway in response to bulky DNA adducts MCM3 MCM5 MCM6 MCM2 MCM7 POLN RAD18 PCNA PMC8235983__F5 Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology TH KY ATM MYC APP DEK TNF UNG PMC12061915__F1 Macrophages in cSCC CTSK IL13 TNFRSF21 CD200 CD40 ARG1 CHI3L1 PMC11174690__F5 SIRT signaling pathway by active ingredients in goji berries NRF1 CPT1A TFAM SIRT1 FOXO1 SIRT3 PMC8178373__F2 Two common mechanisms of aurora kinase A (AURKA) synthetic lethal interactions SMARCA4 RB1 AURKA ARID1A PMC11174690__F4 PI3K-Akt signaling pathway by active ingredients in goji berries NLRP3 LBP BCL2 PTEN MTOR FOXO1 BAX PMC11174690__F3 Fas/Fasl signaling pathway by active ingredients in goji berries CASP3 LBP FADD PMC8149889__F2 Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy KIR2DS1 HLA-G PTN LILRB1 PBX1 CCL3L3 KIR2DL4 XCL2 PMC7692643__F6 Proposed mechanisms of YAP/TAZ activation in CMS4 CRC APC GSK3B LATS1 LATS2 PMC7692643__F2 Hippo pathway LATS1 LATS2 PMC2971463__F3 SLIT/ROBO pathway: a regulator of cell function with implications for the reproductive system PI3 HGF CXCR4 GSK3B GRB2 DCC PMC6670099__F10 The role of PLIP1 in TAG biosynthesis during development of wild-type (WT) and dgat1 seed DGAT1 PC LPA LPCAT2 PMC3983565__F4 MAPK signalling cooperates with loss of APC to promote adenoma development APC EGFR GSK3B CCND1 BMF PMC5026403__F2 Complement activation and immune regulation HEL-S-62p CFB CFD CP PMC7520283__F2 DNA methylation and histone acetylation involved in OA‐FLS inflammation EGR1 VCAM1 TRAF6 IRS1 IL1B STAT3 PMC7520283__F1 MiRNAs involved in OA‐FLS inflammation FOXO3A CCL2 SP1 MTOR IL1B PMC9616825__F8 Schematic illustrating the working model of diabetes-induced bone marrow dysfunction CXCL12 PPARG SP7 TGFB1 PMC7520283__F4 Wnt/B‐catenin signalling pathway in OA‐FLS inflammation FOXC1 APC GSK3B STAT3 CLK2 PMC7520283__F3 Activated NF‐KB signalling pathway in OA‐FLS inflammation VCAM1 IL1B TF PMC3017463__F4 Schematic illustartion of microglial (A) and astrocytic (B) events taking place in the spinal cord in neuropathic pain CX3CL1 CCL2 BDNF PMC10573612__F2 Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions DDR1 MAP2 RHO PTEN DDR2 PMC8070386__F2 Influence of extracellular acidification on melanoma progression SOX2 MMP2 MMP9 KLF4 HEL-S-53e CAD AXL PMC8273913__F4 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer TH EGF VASP HGF HEL-S-28 FLNA SMAD2 VEGFA DAP ARHA MTOR HEL114 TGFA CDC42 PMC9223566__F6 Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex BAD GRB2 BCL2 RAF1 FADD PMC6321433__F3 Cholesterol biosynthesis deficiency syndromes NLRP3 MVK POR IL1B PMC8273913__F3 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer EGF HEL-S-28 RHO CDC42 PMC7468434__F1 Mitochondrial dysfunction in microglia NLRP3 MCU CD36 PMC8533960__F3 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer MYB BAD FAR1 PROC PTEN RAC1 IRS1 BRCA1 RHEB NOG BCR GAL RBL2 CD19 PMC8662355__F2 Roles of Gasdermin D in Coronavirus Infection and Evasion NLRP3 AFP GSDMD PMC3382127__F7 Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived Human Multipotent Stromal Cells STAT1 SOCS3 CXCR4 IRF-1 TLR3 SOCS1 PMC8533960__F5 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer CD47 CD44 VWF CHAD CD36 PMC8485071__F6 Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review SYK EIF4G1 GRB7 PMC8162686__F2 Peg3 downstream genes involved in major metabolic pathways HEL-S-26 SUCLA2 ACLY IDH3B HMGCR FASN PMC11754522__F1 Ceramide biosynthesis pathways (created by Figdraw 2 CERS3 LASS1 DES CERS5 CERK SMS CERS2 PMC11754522__F3 Mechanisms by which nutritional interventions alter ceramide metabolism (created by Figdraw 2 APOB CERS3 LASS1 DES CERS5 SMS CERS2 PMC10382948__F1 Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC5041507__F1 Pathway interaction network of targets of apoptomiRs in breast cancer ARID4B MUC1 EPOR PRKCE EPO TPM1 RTKN SLC7A11 IRAK1 CSNK2A1 TRAF6 BCL2L1 PTEN MTOR CCNE1 TP53INP1 PIM1 SNCG feat TIMP3 NOTCH1 CCND1 RAD52 MTDH EZH2 AXL HEL-S-133P ENPEP ANXA1 FOXO3A FOSL1 ARHA FOXO1 LMTK3 BCL2L2 CASP3 RPS6KB1 MEGF9 MTMR3 ARID3B BCL2 CCNJ MCL1 HEL-S-283 GPD1L TRAF2 CDK9 SIRT1 PMC4695870__F2 Melanoma cells develop resistance to MAPK inhibitors by mutating (mut) or altering expression of a number of proteins which reactivate MAPK signaling and/or activate alternative survival pathways such as the PI3K pathway NF1 FOXD3 BPTF HGF BRAF EGFR NRG1 EZH2 AXL KDM4A PMC6951973__F5 ClueGO pathway enrichment analysis of genes in the yellow module KRT16 RPRM DPP4 LAMB3 DSC2 UNG PROCR MUC2 CST2 CFTR PLAT ULBP2 PRB2 CISH CHAD ACE2 CA12 KCNJ16 PMC8282197__F6 Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors CD14 GSTM5 CX3CL1 VCAN CCL21 S100A12 CDH16 LY96 SULF1 TLR4 ALDH1A3 CD163 GSTM4 UNK CCND1 GSTM3 PMC7589702__F7A Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway AHR RUNX2 UNK PMC7724827__F2 Interplay between EVA71 infection and autophagy PML ULK1 IRF7 MYD88 STX17 SNAP29 APOBEC3G PMC5103287__F1 DGKA and DGKζ in T cell activation and anergy PLCG1 EGR1 EGR2 DGKZ FOXO1 DGKA PMC3861040__F5 Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion FGF23 SMAD4 PTH CFP HEL-S-104 PMC9256556__F1 TNF in the liver: targeting a central player in inflammation RIPK1 TRADD TRAF5 RIPK3 TNF TRAF2 FADD MLKL BAX PMC7073155__F2 BPA action on placental growth CYP11A1 BCL2 PMC7547615__F1 Pathogenesis and immunomodulation of COVID -19: 1 CXCL10 IL33 IRF3 ACE2 CCS PMC9256556__F2 TNF in the liver: targeting a central player in inflammation TRADD TRAF5 TRAF1 TRAF2 PMC7720688__F3 Biological mechanism of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection ACE2 IL1B ADAM17 TMPRSS2 PMC1859939__F5 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction MAX GSK3B MYC PMC6886443__F5 Proposed model of (defective) AP-3 dependent acquisition of VAMP8 during Weibel-Palade bodies (WPB) maturation CD63 VWF VAMP8 PMC7338464__F7 CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils CXCL5 GC CDH2 PMC4139831__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 TNKS PMC4191885__F5 Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain SHH GATA3 FOXA2 PMC5390594__F2 Notch signaling pathways are shown mainly above SOCS3 IRF8 IRAK2 EIF4E PMC5390594__F1 AMPK and JNK signaling pathways are shown above IL16 HEL-S-31 IL1B SIRT1 PMC8125975__F3 Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility NF1 BRAF GRB2 PTPN11 SHOC2 RAF1 SOS1 HRAS PMC5308909__F7 Schematic diagram illustrating the possible interplay between the EGFR and CK2 signaling pathways that regulate GBM cell proliferation EGFR CDC37 PTEN PMC8721005__F8 Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway ELF2 MFN2 ATF4 PMC8577836__F7 Schematic model of the role of tumor-derived extracellular vesicle (TEV) and CD300a in tumor immunity IRF3 CD300A TLR3 PMC7291288__F4 ER stress is involved in NLRP3 inflammasome activation NLRP3 REL IL1B PMC8670134__F2 gcMECM: graph clustering of mutual exclusivity of cancer mutations BRAF PDGFRA EGFR SOST SCRIB FGFR4 SHC3 BRCA1 FGFR2 PLAT E2F7 BRCA2 SI ERBB2 KSR1 RELA PTPN11 RAF1 FANCA RASSF2 SOS1 CASP8 MAL PMC9390238__F6 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy RET BAG3 PTEN MTOR PMC4731230__F2 MuSC function are altered in aging GDF11 STAT3 PMC5366789__F1 Suggested signaling pathways for induction of the immunosuppressive catabolic enzyme indoleamine 2,3-dioxygenase (IDO1) in vertebrate dendritic cells (DCs) SMAD2 TRAF3 SMAD4 TRAF6 CD40 CD80 TRAF2 PMC7205985__F7 REGGamma-dependent regulation in ATC dedifferentiation SMAD2 SMAD4 PAX8 PMC9926763__F8 Sirtuin 3 regulation: a target to alleviate Beta-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells ULK1 MTOR SIRT3 PMC4535331__F1 Reflex control of immunity HMGB1 NCL ARC PMC6799818__F5 Additional gut microbial metabolites regulate host immunity and metabolism WNT3 AHR IL25 IL1B PMC6412895__F2 Signal transduction pathway of EGFR EGFR GRB2 MTOR PMC3989546__F1 Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer GAB2 MYC GRB2 TYK2 JAK3 JAK1 IL4 DNMT3B STAT3 PMC6147766__F2 Role of Helicobacter pylori in the reprograming of cellular and molecular programs related to invasive behavior PLG CD44 SP1 PMC6487278__F4 Schematic model for Cbl-b in BCR- and CD40-mediated signaling pathways Activation of CD40-dependent signaling pathway is mediated primarily by several TNFR-associated factor (TRAF) protein family members including TRAF2, 3, 5, and 6 BTK BCR TRAF5 BASH LYN TRAF3 TRAF6 CD40 SYK PLCG2 TRAF2 PMC9390238__F2 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy IGF1 BAG3 SLC38A9 EEF2 CASTOR1 PTEN EIF4E RPS6 EIF4B RHEB PMC8141729__F7 Beta-Asarone Ameliorates Beta-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway MAF KEAP1 BAX PMC7547615__F3 Mode of action of MSC's for treating COVID-19: 1.Ifusion of MSC's 2 EGF HGF MSC BNIP3 ACE2 PMC6296341__F1 Two synthesis pathways of fucosylation FUT8 GMDS FUT1 FUT4 FUT6 POFUT4 FUT5 FUT9 hCG_1998026 FUT7 POFUT3 FUT3 PMC6428271__F5 Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells TBK1 BAD LIMK1 TRADD HEL-S-28 CDC37 EIF4E TNF MTOR LMNA DIABLO HTRA2 RHEB GAS2 DFFB DFFA MDM2 SPTAN1 MCL1 TRAF2 FADD CYCS ARHGDIB ACIN1 PMC8274634__F1 Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control SET AgRP ARC RGS2 PMC3238469__F2 Gene expression changes in cell cycle pathways MAPKAPK2 CCNI2 POLE ATM HUS1 PTGS2 MAPK3 EZH2 MSH2 FANCA ATR PMC3547545__F1 An illustration of the IIF pathway genes.Notes: Arrows indicate the direction of signal transduction PIK3R1 PDK2 INS PDK4 PIK3R3 IGFBP5 INSR IGFBP1 F3 PDK3 IGFBP4 IGFBP2 PIK3CA IGFBP6 PIK3R2 AKT3 PMC5516854__F3 Visualizations of Wnt pathway reconstructions PIK3R1 PLCB3 FZD3 PAX2 FLNA CSNK2A1 EGFR WNT1 MAPK3 SMAD2 GSK3B SMAD4 RYK FZD1 PRKCA RPS27A FZD2 NOTCH1 SRC DVL2 FZD7 MAPK1 ROR2 CDH2 FZD10 TCF3 APC LRP5 MAP3K7 LRP6 DVL3 DVL1 FZD5 PLCB1 CFTR PLCB4 PLCB2 LEF1 NFATC2 AXIN1 PIK3CA hCG_2014051 GNAO1 CSNK2B SMAD1 TCF4 FZD8 PMC6034273__F10 Interaction among MCP-1/CCR2 signaling, TLR4, and GSK3B in ethanol-induced neuroinflammation CCR2 TLR4 GSK3B IL6 MYD88 PMC11865046__F7 TMYXP's key blood components and mechanisms for treating the elderly CHD CHUK HSP90AB1 PTGS2 TGFBR1 CXCL8 BCL2L1 ITGA4 RB1 TNF HEL-S-22 CASP3 RPS6KB1 CD27 ITGAV TGFB1 PMC5507964__F1 TLR7/TLR9 and B cell receptor (BCR) ligands incite B cell signaling cascades TLR9 IRF7 IRAK1 UNC93B1 DOCK8 TRAF6 IRAK4 IRF3 PLCG2 MYD88 BLK BTK TLR7 BCR BASH BANK1 BIK LYN SYK STAT3 PMC5336341__F2 Proteomics and tracing experiments reveal the presence of previously unappreciated metabolic pathways in mature RBC.(A) An overview of the central metabolic pathways that are reasonably active in RBC in the light of proteomics evidence CTH PIG59 SHMT1 MTHFD1 HEL-S-32 HEL-S-26 FH PSPH ACLY ARG1 SMS LAT ASL MAL SLC19A1 PMC10239240__F5 Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD SOCS3 IL6 IL6R STAT3 PMC4958247__F10 Ehrlichia chaffeensis TRP120-mediated activation of canonical Notch signaling pathway and inhibition of TLR2/4 expression TLR4 NOTCH1 ADAM17 PMC8848293__F2 Maintenance of protein homeostasis in glia extends lifespan in C. elegans ATF4 XBP1 PMC8085043__F1 Current Concepts and Advances in Graft-Versus-Host Disease Immunology CTLA4 ARG1 PMC3293584__F1 Schematic of folate-mediated one-carbon metabolism in the cytoplasm and nucleus SHMT1 DHFR TYMS PMC10854459__F8 Anticancer role of JAC in AGS cells BAD WNT3A CDK2 CDK4 CDH2 CDK6 STAT3 PMC8458965__F2 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis TBK1 OTUD1 PPM1G TRIM21 NLRX1 TRIM25 FAF1 RNF125 NLK RNF5 OGT PCBP1 RNF34 MAVS PMC7461825__F1 Role CRP on the innate immune system and tumor progression CRP PTEN MTOR PMC7565831__F3 Amino acid sensing by mTORC1 SLC38A9 CASTOR1 ARF1 RHEB PMC7906923__F1 Molecular signaling pathways implicated in neuroblastoma ALK EGFR MDM2 HIF1A MTOR FZD1 BDNF PMC2890581__F7 Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice EDARADD EDAR TRAF6 PMC9048116__F7 Autotaxin signaling facilitates B cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency ENPP2 LPA SIRT3 PMC6336527__F2 UV-induced cutaneous tanning response POMC PC DCT TYRP1 MC1R PMC8712140__F13 To Predict Anti-Inflammatory and Immunomodulatory Targets of Guizhi Decoction in Treating Asthma Based on Network Pharmacology, Molecular Docking, and Experimental Validation CHUK IKBKG EGFR MAP3K7 MAP2K2 TNF TNLG7C MAP3K7IP1 IKBKB NFKBIA IL16 MAP2K1 NFKB1 RELA GRB2 MAP3K14 RAF1 CSF1 AKT3 PMC1617297__F2 Cell-signaling networks induced by Pichinde virus infection as analyzed using the Ingenuity pathway analysis knowledge base PRKCI FHIT PGR FOS MYC PTEN RB1 ID3 E2F3 PLCB1 CBL RFC1 EDNRA EGR2 E2F2 ZNF148 RELA TP73 DCTN1 XPA ERCC2 DPT NFKBIE TERT PMC6053276__F1 A simplified representation of the HIPPO pathway NF2 LATS1 LATS2 PMC6492170__F1 Schematic representation of iron metabolism in the yeast model CMIP HEL-S-11 FES PMC7445288__F6 Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate RNF43 BRAF MAP2K4 EHF PTPRK ERBB3 APC GSK3B ARID2 TCF7L2 PTEN RB1 FBXW7 NF1 RSPO3 ELF3 ATM ERBB2 PSIP1 CCND1 PMC8198587__F3 Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression KAT5 LEF1 RUVBL1 LRP5 LRP6 PMC8458965__F3 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis TBK1 F2 PPM1G NLRX1 MAVS PMC12014800__F2 Value-added products derived from fatty acids and derivatives, which can be synthesized by yeast cell factories with tuned fatty acid profiles PALM PMC9367355__F5 The Cancer Stem Phenotype by Long Non-Coding RNAs PTEN EZH2 HEL-S-68p PMC9367355__F4 The Cancer Stem Phenotype by Long Non-Coding RNAs HDAC1 PHB2 PMC10559995__F1 Signaling Pathway of Estrogen Receptor EGF EGFR TF PMC10559995__F3 Estrogen metabolism pathway in humans UGT1A3 UGT1A9 STS PMC5866458__F1 A change of view: homologous recombination at single-molecule resolution DMC1 SSB RAD51 PMC7731470__F4 Illustration of the effects of polycystins dysfunctioning on EGFR and MAPK/ERK pathway EGF IGF1 EGFR GRB2 PMC8353397__F9 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis ROCK2 CXCR4 MIP JUN PMC7922523__F4 TGFB/EMT signalling in pSS SMAD2 TGFBR1 SMAD4 TGFBR3 PMC6316148__F2 Relationship between mechanical loading and sclerostin expression SOST LRP5 LRP6 PMC10552500__F3 Nutraceutical-mediated signaling pathways underlying some neuroprotective processes BACE1 COX2 NGF APP ADAM10 BDNF BAX PMC9367355__F3 The Cancer Stem Phenotype by Long Non-Coding RNAs IGF2BP1 SOX2 CBY1 CD44 TCF7L2 SP3 PMC11827473__F6 Anti-tumor effects of ArcA on the aggressive behavior of metastatic melanoma cells MMP9 CDK4 PMC8261167__F2 Emerging mechanisms and targeted therapy of ferroptosis in cancer HEL-S-102 GPX4 LPCAT3 FACL4 KEAP1 ADA IREB2 POR TF HMGCR PMC8261167__F1 Emerging mechanisms and targeted therapy of ferroptosis in cancer CTH GPX4 SLC7A11 HEL-S-64p ATF3 SLC3A2 SLC38A1 BAP1 GLS PMC5492138__F5 Mechanism of encoding the NSC modules GCA GCG GAA PMC8261167__F4 Emerging mechanisms and targeted therapy of ferroptosis in cancer HMGB1 GPX4 AGER SLC7A11 SLC3A2 JAK1 ARG1 TGFB1 HCAR1 IFNG STAT3 PMC2263022__F6 Superposition of 'omics' data on maps ATM TTK APC CENPF XPC CENPE PCNA TRAF4 CENPA BAX PMC6695732__F6 Model of ESRP1-mediated cell cycle G1-phase arrest CCNA2 CDC20 ESRP1 PMC7322029__F7 Cartoon comparing canonical Hippo signaling with signaling by Legionella LegK7 YAP1 LATS1 PMC7793796__F5 CAM-DR in leukemia VCAM1 GSK3B CD44 PMC5713154__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection CPA3 MAS1 PIKFYVE CTSA MTOR ACE2 MME PMC8424139__F5 Diagram depicts the regulation of retinoid metabolism by PI3K-AKT pathway in RPE LRAT RPE65 RDH12 RDH8 RDH10 PTEN RDH5 ADH7 RPE PMC3761196__F8 This figure depicts a model of the lipid synthesis genes in the human mammary epithelial cell during secretory activation according to cell compartment GK5 FACL4 AGK ACSS2 ESRRA HEL-S-32 GPAM THRSP CH25H LPIN1 ACACB LPL XDH FASN SCARB1 ADFP TG ACSM3 DBI DGAT1 VLDLR BTN1A1 INSIG1 FDFT1 ABCG1 ABCA1 ACLY GPD1L SLC25A1 PMC3761196__F7 Cell compartment view for network of lipid metabolic genes highlighting the role of SREBF1, THRSP, and ESRRA curated by ingenuity pathway analysis (IPA) FACL4 ACACA IDI1 ACSS2 ESRRA GPAM ACOX1 HEL-S-26 APOM FDPS ACACB LPL SREBF2 ACSL1 NR1A2 NR1H3 DLAT SDHB FASN SQLE SCARB1 HSD17B1 HMGCS1 ELOVL6 NR1C1 HMGCR LEP PMVK MVD FADS2 DHCR7 FDFT1 ACADVL PPP2CA PHYH ACLY PPARG EHHADH ACADM CD36 PMC11353167__F2 MAPK signaling pathway ATF2 JUND RHO RAC1 JUNB CDC42 PMC7999830__F7 The proposed model NFE2L2 HMOX1 IL1B PMC11353167__F1 FCERI signaling pathway FYN BCL10 GAB2 LYN GRB2 SYK LAT PMC6065096__F8 R431C mutation induces hyperproliferation, hypermotility and ER stress-induced apoptosis in podocytes RAC1 MTOR CD2AP PMC3282414__F2 Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities NF1 PDK2 SHANK3 SHANK2 ARC PTEN HRAS MTOR PMC7022340__F6 Working model of the roles of Beta-catenin and US3 in the DNA-sensing signaling pathway TBK1 CGAS APC GSK3B IRF3 PMC11313500__F2 Molecular pathway mechanisms of cytokines and chemokines associated with inflammation for the progression of pulmonary hypertension SMAD2 MYD88 PMC6921378__F5 Molecular models of the potential role of proteins involved in the Nrf2 – mediated response to NCC exposure ATF4 APC HEL-S-8a HEL-S-92n PMC3761885__F2 Proposed regulation of cardiac Per2 ADORA2B EGFR SKP1 NEDD8 RBX1 PER2 PMC9489100__F2 Lung involvement in monogenic interferonopathies TBK1 CGAS STAT2 IRF9 POMP COPA IRF3 IFNAR2 IFNAR1 USP18 STAT1 ISG15 DNASE2 ATM TREX1 NGLY1 TYK2 ACP5 MAVS PMC6076434__F8 Schematic view of pathways regulating IL-1A expression in hRPE cells TLR4 IRF7 IRF3 MYD88 IL1B TIRAP PMC3283716__F1 Novel Classification of Lung Cancer into Molecular Subtypes BAD BCL2 PTEN MTOR PMC5331196__F1 Sensing infection and tissue damage STAT1 STAT2 IRF9 IRF3 MAVS PMC5580489__F3 Host DNA damage response pathways FANCD2 ATM TOPBP1 BRCA2 ATRIP RAD50 FANCA ATR H2AX MRE11A BRCA1 PMC7471766__F3 Classic and trans-signaling IL-6R JAK1 ADAM17 STAT3 PMC10551140__F7 Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway NLRX1 BNIP3L BNIP3 MTOR PMC4339430__F6 Proposed role of CCL21/CCR7 axis in lymphangiogenesis VEGFC CCR2 CCL21 CCR7 PMC7497240__F2 A) Comparison of the putative biosynthetic gene cluster (BGC) of tjipanazole biosynthesis in F TJP1 STAC PMC8542988__F3 Shedding Light on Microbial “Dark Matter”: Insights Into Novel Cloacimonadota and Omnitrophota From an Antarctic Lake GHB2 RAN PMC2900152__F9 Proposed DAP12 signaling pathway in macrophages and osteoclasts VAV3 GRB2 SYK PMC7907466__F1 Complement Cascade in HIE C9 C7 C6 PMC4474341__F1 Biochemical pathways MCC IVD PMC8466551__F1 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis SUFU GPR161 GSK3B SMO PMC3913970__F1 BCR/BTK signaling pathway BTK BCR LYN SYK MTOR PMC8466551__F3 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis SNAI1 MMP9 VEGFA CCL5 CCL2 NRP2 SOX9 CCND2 MMP3 MMP14 MMP2 TWIST1 ZEB2 CCND1 BCL2 ABCG2 CDH2 ABCB1 BAX PMC3679383__F1 Pathways of GPL biosynthesis in eukaryotic cells: temporal regulation of GPL-synthesizing enzyme activities PC PTN PGP LPA PSD PEMT PMC8466551__F6 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis LRP5 VEGFA SHH LRP6 MTOR NRP2 PMC2642659__F2 Visualization of molecular interaction and reaction networks in the KEGG database ROCK2 IGF1R APC LRP5 PROC CER1 SMAD4 LRP6 SKP1 GIP ARHA RBX1 INSR NLK FER DAAM1 SIAH1 FGFR1 ERBB2 IQGAP1 SRC LMO7 CDC42 PMC8466551__F5 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis PTCH1 SHH SMO SP1 PMC5785435__F2 Bevacizumab-Induced Hypertension: Clinical Presentation and Molecular Understanding BAD COX1 CASP9 APP PMC5564072__F5 T cell receptor (TCR) signaling pathway in melanoma (modified from the BioCarta database) TH FYN LCK ZAP70 GRB2 RAF1 LAT PMC8965842__F4 MiR-223 as a Regulator and Therapeutic Target in Liver Diseases NLRP3 PKNOX1 CXCL10 LDLR CXCL2 VTA1 APOE STAT3 PMC11930265__F9 LTA promotes aerobic glycolysis (AG) and M1 polarization in macrophages by activating the NFKB signaling pathway BAD LTA HIF1A HK2 PMC3959571__F1 Q6 biosynthesis in S COQ4 COQ3 COQ2 COQ9 C6 COQ5 COG5 COQ7 PMC3711327__F7 A model for the regulation of transcriptional induction of ICL1 and FBP1 by the PIPTC PI3 TBP FBP1 PMC5943571__F1 Pathway for glycosphingolipids (GSLs) biosynthesis B3GALT4 PMC11049046__F6 KEGG pathway of the PI3K-Akt signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 MYB TSC2 BAD CD37 BCR GRB2 SYK MTOR RBL2 RHEB CD19 PMC11049046__F5 KEGG pathway of the MAPK signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 CD14 EGF TRADD DAO FLNA TNF FAT4 NLK BTK MAX ECSIT TRAF2 MEF2C ASL PMC4550685__F1 Intracellular pathways of factors regulating adipogenesis, lipogenesis and lipolysis in the adipocyte AK2 PDE3B GC LPL TG INSR STAT3 PMC7646947__F3 Receptors and substances involved in metabolism that affect muscle protein synthesis and degradation in cancer cachexia NR1i1 IGF1 PDK4 PMC7646947__F1 Molecules and signaling pathways involved in muscle protein synthesis and degradation IGF1R IGF1 MTOR STAT3 PMC8018731__F11 NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition HEL70 CS SRC PMC7851083__F1 Important events during research development of macropinocytosis in cancers ARHA PALM CDC42 PMC8466551__F7 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis MED12 IGF1R SKP1 SPOP SOX9 PMC3031870__F1 MTORC1 and mTORC2 signaling branches TSC2 TSC1 PTEN RHEB PMC3335081__F9 Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation RUNX2 MSC SIRT1 PMC7851083__F3 Mechanism of extracellular proteins internalization through macropinocytosis ATF4 EGFR PTEN RAC1 PMC3285217__F1 Drosophila signaling pathways that regulate humoral responses DAP MYD88 FADD PMC3331679__F2 mTOR signaling in growth control and disease EEF2K ULK1 EEF2 PTEN RHO EIF4E RHEB TSC2 NF1 TSC1 MAP4K3 IPMK YY1 MAF1 EIF4B SGK1 PMC4149926__F1 Cytomegalovirus microRNAs RAB11A VAMP3 MICB ATP6V0C CD34 MAPRE2 BRCC3 RAB5C SNAP23 CDC42 EID1 CCNE2 PMC9308931__F8 Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii TANK TLR9 IRF7 IRF8 TRAF6 IRAK4 IRF3 MYD88 TNF TLR1 TLR3 TLR8 BTK COX2 TLR4 SIGIRR TIRAP PMC7984366__F2 Endogenous estrogen regulates the proliferation and differentiation of NSPCs EGFR SRC GPER PMC7984366__F3 Estrogen-like molecules activate the classical estrogen signaling cascade and alternative pathways GSK3B SIRT1 GPER PMC5332937__F1 Canonical WNT signaling pathway LEF1 APC LRP5 GSK3A CCND1 LRP6 PMC10297136__F3 Signal pathways associated with lung adenocarcinoma NF1 TSC2 TSC1 ATM APC EGFR MDM2 STK11 MTOR PMC6743980__F2 Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics VLDLR PLG EGFR TGFBR1 RHO PMC8692119__F1 Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process BCR RELA GSK3B RELB MTOR TRAF2 ICOS CD19 PMC5759931__F6 Proposed working model by which boehmenan exerted anti-proliferative activities in A431 cells EGF EGFR STAT3 PMC8085043__F2 Current Concepts and Advances in Graft-Versus-Host Disease Immunology ROCK2 IL21R BTK CSF1R GC SYK JAK1 CSF1 STAT3 PMC10297136__F5 Glioblastoma multiforme (GBM)-related signal pathways NF1 CDKN2B EGFR CDK4 RB1 MTOR PMC11700987__F2 Staphylococcus aureus prevents Nrf2 pathway activation in THP-1 macrophages through upregulation of MAPK/p38 and downregulation of p62/SQTM1, scheme modified from [35] KEAP1 CCL2 TNF PMC11700987__F1 NRF2/KEAP1 signaling pathway adapted from [17] GCLM KEAP1 RBX1 NQO1 PMC11700987__F6 Keap1/Nrf2 signaling pathway plays a crucial role in the cellular response to P KEAP1 EGFR HBEGF TGFA HMGN2 PMC11700987__F4 Listeria monocytogenes evades the host immune response by Tim-3-dependent inhibition of the Keap1/Nrf2 signaling pathway KEAP1 CD36 PMC9592927__F3 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer FAM83A EGFR KLF8 STAT3 PMC11700987__F3 Activation of Nrf2 in S MAF KEAP1 SFN TNF PMC7272282__F1 PI3K pathway TSC2 PI3 TSC1 PTEN EIF4E INPP4B PMC4367834__F5 Dopamine biosynthesis and degradation and the genes coding key enzymes TH PNMT DDC ST1A5 DBH ALDH3A2 MAOA AKR1B1 PAH PMC6770301__F2 Regulation of EMT at different molecular levels: upregulation of the WNT pathway, PI3K/AKT pathway, and RAS/RAF/MEK/ERK/MAPK pathway and downregulation of the TGFB/Smad pathway lead to the activation of EMT through downregulation of E-cadherin SOX2 APC GSK3B SMAD4 MAPK1 FOXC2 IL1B SNAI3 TCF4 STAT3 PMC7272282__F3 Crosstalk between PI3K signaling and DNA damage repair pathways FANCD2 ATM BRCA2 EMSY RAD51 BRCA1 UBE2S PMC7272282__F2 Cell cycle checkpoints WEE1 ATM CDK2 SSB CDK4 CDC2 ATR CDK6 CCNE1 PMC4626177__F6 Pathway network analyses of upregulated genes from early stage (stages II and IIIa) TNBC STAT1 KLK5 IGFBP2 CDH2 TNFRSF11B CTNND2 CLU PMC4626177__F7 Pathway network analyses on upregulated genes from late stage (stage IIIc) TNBC EGF HOXA13 LEF1 SNAI1 PAX2 MAPK10 MSX2 SNAP25 RAB3B PMC3928651__F2 Solving Glycosylation Disorders: Fundamental Approaches Reveal Complicated Pathways ALG9 MAGT1 ALG13 DPM2 DPM3 RFT1 DPM1 ALG1 STT3A ALG3 ALG12 KRTCAP2 ALG8 STT3B ALG10 GMPPB TUSC3 DDOST PMC9592927__F2 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer EGFR ADAM28 STAT3 PMC5578163__F1 Physiology of the VHL-HIF pathway along with proposed etiopathogenesis that leads to metastatic ccRCC EPO TWIST1 CXCR4 EGFR CCR7 VHL SHH BMI1 MTOR PMC4775036__F5 Main canonical pathways induced by cigarette smoke extract CNTF NGF TREM1 FLT3 HIF1A PMC1609106__F8 Regulation of insulin pathway phenotypes by AKT-1 and PDK-1 activation PMC6059118__F1 USE1 is a critical ubiquitin-conjugating enzyme in lung cancer cells USE1 UBA6 RGS4 PMC11539471__F2 Mechanisms of action of clinically studied CAR-T targets in gliomas IL13RA2 IL13 VEGFA MTOR EPHA2 STAT3 PMC7845757__F7 Mechanisms underlying DAC-paracetamol interaction COX2 CYP2E1 PMC7177421__F1 Receptor 4 (TLR4) general signalling transduction pathway CD14 TLR4 IRF7 IRAK1 TRAF6 IRAK4 MYD88 PMC8869442__F2 Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19 ISG15 OTUB2 USP4 USP15 TLR4 IRF7 CYLD IRF3 TRIM25 MAVS USP18 PMC7105732__F1 “Four Hits” Hypothesis of IgA Nephropathy TH TLR7 TLR4 TLR9 PMC3558870__F1 The potential disruption of hepatic GH signaling pathways by MC SOCS3 GHR GRB2 IRS1 PMC7522543__F6 The prostate cancer pathway PIK3CD GSK3B CREB1 RB1 E2F3 FGFR2 CCNE1 PI3 FGFR1 KLK3 MDM2 CASP9 NKX3-1 SOS2 ERG CDKN1B TCF7L2 HRAS CREB3 FOXO1 CDKN1A GRB2 BCL2 TGFA TF AKT3 CREB3L2 IKBKG CHUK BAD BRAF HSP90AB1 EGFR PTEN MTOR PDGFD PLAT ATF4 PDGFA E2F2 CCND1 SRD5A2 TCF7L1 ARAF TMPRSS2 CCNE2 PDGFRA MMP9 MAP2K2 HEL-S-125m IKBKB NFKBIA CREBBP EP300 MAP2K1 PDGFC ERBB2 NFKB1 RELA PIK3CA ETV5 SOS1 PMC4362880__F1 Beta-amyloid precursor protein (BAPP) processing in Alzheimer’s disease (AD) and age-related macular degeneration (AMD) TSPAN12 CD33 ADAM10 TYROBP PMC3808429__F7 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology PLCG1 ERBB2 EGFR VEGFA SRC JAK1 HIF1A SHC1 STAT3 PMC3808429__F6 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology PIK3R1 NFKBIA CHUK ERBB2 NFKB1 EGFR GSK3B HEL-S-72p PMC2665046__F3 Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin-Dependent N-End Rule Pathway ATE1 NTAN1 PMC7051146__F1 Pro-viral roles of autophagy during virus infection ULK1 ATG12 MTOR MAVS PMC7969890__F1 Elements of the classical and alternative complement pathways, separated by the unique and common aspects HEL-S-62p C4B_2 PMC4276135__F2 Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling BASH RAG1 IL7R CCND3 IRF4 ID3 RAG2 PMC4682379__F4 Transcription_P53 signaling pathway TDG VEGFA XPC RANBP2 MTA2 PIAS2 ATM MAP4 FHL2 PIAS1 XPA ATR SUMO1 PMC7676935__F2 Summary of the possible signaling pathway between gut microbiota-bile acids axis and IBS-D NR1i1 NGF PMC5053351__F7 The Pga1-mediated signal transduction pathway, showing the effectors AC and PKA previously reported in different fungi, along with newly identified effectors and proteins and their relation with the cellular processes regulated by Pga1 RAN TK1 PMC3499368__F1 Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors PMC6013028__F2 Direct effects of thyroid hormones on hepatic lipid metabolism SOAT2 CDX2 FDPS ABCG8 ABCG5 LPL LDLR HMGCR CYP7A1 PMC7199749__F1 Genomic stabilization by TTK TTK KNL1 PMC8453015__F3 Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases TBK1 CGAS IRF3 PMC4452497__F9 UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 EDNRB PMC11477111__F6 Regulatory role of FMR1/FMRP on BMPR2 in granulosa cells BMPR2 ALK BMP15 FMR1 PMC5915462__F1 Pathways of deoxyribonucleotide metabolism in mammalian cells ADSL INS DHODH PMC11667896__F2 GLP-1 (glucagon-like peptide-1) plays a vital role in neuroprotection and regeneration through multiple mechanisms CASP3 NRF1 CASP9 BAX PMC3519947__F1 Simplified diagram illustrating the mTOR signaling pathway MTOR PSD PMC9122672__F1 Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn's Disease CYP27A1 CYP8B1 CYP7B1 CYP7A1 HSD3B7 PMC4395138__F1 Extrinsic and intrinsic pathways of apoptosis APP TNF FADD PMC2736107__F2 In addition to the hypothesis outlined in , a number of other mechanistic pathways could potentially lead to the formation of products 3-5 () ARX PMC7590567__F1 Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors BAD TRADD BIK PTEN CSA2 MCL1 BMF TRAF2 FADD HRK PMC5143325__F1 Reactions induced by oxytocin CHUK PRKCE NPPA FOS PTEN MTOR ALPL SIAE PLAA TRPV2 OXTR RELA OXT LNPEP PMC2610675__F6 Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells FYN EGFR GRB2 ARR3 PMC6616656__F2 Long non-coding RNA acting within the NODAL signalling pathway DAND5 LEFTY1 NODAL PITX2 SMAD2 LEFTY2 SMAD4 FOXH1 PMC5817857__F2 An RTK and the downstream PI3K/AKT pathway RICTOR MTOR DEPTOR PMC9574935__F1 SARS-CoV-2 accessory proteins in immune evasion IRF3 JAK1 TRIM25 MAVS PMC2939266__F3 Dopamine-sensitive signaling via adenylyl cyclase (AC), phospholipase C (PLC), and phosphatidylinositol-3-kinase (PI3K) systems PTEN EIF4E DRD2 MTOR PMC114459__F1 Mechanisms of ISG induction STAT1 STAT2 IRF3 TYK2 PMC3044944__F6 Hypothetic model for TGF-Beta-regulated KLF4 proteolysis SMAD2 APC KLF4 PMC5386709__F7 Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells TSC2 PTEN ATR GRN PMC4272576__F2 Candidate genes influenced by Zn2+ or involved in Zn2+signaling and metal ion homeostasis associated with the development of ASDs MTF1 SHANK3 SHANK2 COMMD1 PMC5577170__F7 Schematic representing the key role of IFNA and LPS-activated monocyte-derived exosomes in brain endothelial stimulation TLR4 PTN VCAM1 IL6 CCL2 IL1B PMC7587305__F3 XRCC1 participates in BER by facilitating transfer of DNA damage PARP1 PMC9529500__F3 Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells RHOD BMPR2 SUFU APC CXCR4 GSK3B SMAD4 SHH SMO SMAD1 DKFZp781O1323 SMAD9 PMC6099164__F2 Transforming growth factor‐B (TGF‐B) promotes T helper 17 (Th17) differentiation through multiple mechanisms ROCK2 IL21R SOCS3 RUNX1 SMAD2 SMAD4 ARHA IL2RA TGFA IRF4 STAT3 FOXP3 PMC9098327__F4 Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer MAF AHR RBX1 NQO1 PMC8080601__F3 Processing, extracellular regulation, and signaling mechanisms of GDF11 and MSTN BMP1 ACVR2A SMAD2 SMAD4 GDF11 pp6425 SMAD1 DKFZp781O1323 SMAD9 FSTL3 PMC3541634__F1 Schematic of TGFB1 signaling pathway and its regulation SMAD2 SMAD4 SMURF1 PMC8468667__F7 MicroRNA-Based Risk Score for Predicting Tumor Progression Following Radioactive Iodine Ablation in Well-Differentiated Thyroid Cancer Patients: A Propensity-Score Matched Analysis PIK3R1 AGO2 DICER1 MYC BCL2 BCL2L1 PTEN TNF E2F3 SIRT1 PMC7587305__F5 XRCC1-APLF – an interaction between two DNA scaffolds APTX PNKP APLF PMC2800820__F1 Multiple pro-inflammatory mediators in the tumor microenvironment increase the accumulation of MDS cells and enhance their immunosuppressive activity HEL-S-62p COX2 IL1B PMC6011883__F2 Complexes formed by mutant p53 and their roles in breast cancer SENP1 DAB2IP RAC1 TNF INSR PMC8230471__F8 Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy EGF BAD IGF1 MTOR IRS1 PMC3518431__F2 Autophagy modulation as a potential therapeutic target for diverse diseases ULK1 PI3 NBR1 PMC10299133__F1 HGF/MET signaling pathway and most frequent alterations in NSCLC HGF STAT3 PMC3518431__F1 Autophagy modulation as a potential therapeutic target for diverse diseases RAP2B ULK1 TFEB RHEB INSR PMC2841835__F1 Host defence signaling pathways in Caenorhabditis elegans model TPH1 SGK1 PMC7028286__F5 Top two modules from the PPI interaction networks CD9 GOLPH2 SLC1A1 TIMP1 CD63 APP ENG TFRC HK2 CD81 GLS PMC5415012__F1 Schematic representations of selected modes of cross-talk between autophagy and the secretory pathway SEC16A ULK1 TECPR2 ULK2 PMC8709197__F7 Global Metabolic Map Defines the Effects of a Si-Based Biostimulant on Tomato Plants under Normal and Saline Conditions SI PURA CGA PMC7662679__F1 Monoclonal antibodies: types and mechanisms of action CD80 PMC4721243__F4 DDN, (b) GDNPN, and (c) GDNnon-PN of PI3K events in ERBB2 signaling (M570) pathway EREG EGF FOXO4 CHUK BAD EGFR CREB1 PTEN ERBB4 MDM2 CASP9 DDN FOXO3A CDKN1B ERBB3 NRG2 GSK3A HBEGF NRG1 TSC2 RICTOR CDKN1A ERBB2 RPS6KB2 GRB2 PIK3CA AKT3 PMC4721243__F3 DDN, (b) GDNMES, and (c) GDNnon-MES of Integrin AIIb B3 signaling (M760) pathway FGA ITGB3 DDN CSK TLN1 RAPGEF4 CRK PDPK1 HEL-S-78p RAP1A PTPN1 GRB2 SRC SYK SOS1 SHC1 APBB1IP PMC3446651__F2 Viral proteins inhibit nucleic acid receptors of the intracytosolic innate immune response TBK1 C6 TRAF6 IRF3 MAVS PMC11676821__F3 Action of PAK2 in the regulation of different signaling pathways in different cancers SOX2 FACL4 CDK12 MCM7 STX17 SP1 MTOR PMC7418434__F1 Pathways controlling ferroptosis, necroptosis, and pyroptosis NLRP3 RIPK1 GPX4 RIPK3 MLKL PMC6959074__F3 Roles of sirtuins may be involved in nicotine/nAChR-mediated signaling pathway SIRT2 SIRT7 CHRNA5 SIRT4 SIRT5 SIRT6 CHRNB4 CHRNA3 SIRT1 SIRT3 PMC6959074__F2 nAChR-mediated signaling pathways that lead to lung cancer progression EGF EGR1 SOX2 YAP1 FGF2 EGFR MYD88 GATA1 NLRP3 SRC RAF1 SP1 STAT3 PMC9368800__F1 Delivery of Nucleotide Sugars to the Mammalian Golgi: A Very Well (un)Explained Story SLC35A1 SLC35B4 GPR89B SLC35A3 SLC35C1 ATP2A2 PMC12128733__F14 Effect of Withania extracts in two doses on the eicosanoid signaling pathway PTGFR ALOX15 ALOX12 PMC4498740__F3 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells HEL-S-11 RELA LAT PMC7417311__F6 Current Sarcoidosis Models and the Importance of Focusing on the Granuloma TNFRSF18 CSA2 JUN PMC4498740__F2 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells COMP LAT PMC6599319__F1 Simplified schematic illustration of pathways for Wnt/Beta-catenin, ERK/MAPK and PI3K/Akt and PGE2-metabolism COX1 APC GSK3B PTGES PMC5002928__F3 Overlapping RAS/MAPK and PIK3CA/AKT/mTOR signaling pathways and potential therapeutic targets NF1 TSC2 TSC1 BRAF GRB2 SOS1 MTOR PMC3744367__F1 mTOR couples cellular nutrient sensing to organismal metabolic homeostasis TSC2 TSC1 MTOR RHEB MLST8 PMC3360922__F1 Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances BMP6 FECH HAMP VHL TMPRSS6 HFE HIF1A NDFIP1 STAT5B TF TFR2 PMC6484299__F7 Schematic representation showing that B‐arrestin2 (ARRB2) negatively regulated NOD2 signalling pathway through the association with TRAF6 in cerebral ischaemia/reperfusion injury DKFZp686L0365 MMP9 TRAF6 NOD2 PMC7041253__F2 Lipoprotein metabolism dysregulation in lysosomal acid lipase deficiency a) The liver secretes VLDL, which is lipolyzed in the periphery by LPL and HL to generate LDL NPC1 LPL LDLR ABCA1 NPC2 PMC6207572__F1 Dual functions of IFITM3 in the innate antiviral immune response STAT1 STAT2 IFITM3 IRF3 PMC1359062__F1 Ciliated cell differentiation into goblet cells requires 2 signals EGF EGFR TGFA PMC12105221__F3 Several classical mechanisms of EDCs that contribute to the development of endometriosis [79, 80] AHR MMP2 MMP9 FOXP3 PMC12105221__F2 Estrogenoids contribute to the development of uterine fibroids through alterations in epigenetic pathways [17, 56] DES GDF10 ME3 IGFBP5 PMC8964223__F3 Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn's Disease FGF4 FGF19 CYP7A1 PMC11704687__F6 Signaling pathway model DCLK1 BIRC5 AREG LATS1 LATS2 PMC5644625__F1 Activation of the complement system HEL-S-62p C9 C4B_2 VTN C7 C6 C1S C4A PMC3876738__F2 Therapeutic targets in cancer cell metabolism and autophagy ATG12 ATG3 ATG10 MTOR DKFZp686F0183 PMC12105221__F4 How BPA contributes to the development of endometrial hyperplasia, endometrial cancer and infertility through DNA methylation alterations [12, 100] MUC1 RET FBLN2 LCN2 MBD2 DNMT3B HAND2 PMC8358862__F8 Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy NLRP3 TLR4 KEAP1 SHH SMO TXNIP PMC8313886__F2 N6-methyladenosine methyltransferases: functions, regulation, and clinical potential TRIM11 PHLPP2 SOX2 FOXO3A PRDM2 MYC DROSHA PTEN WTAP MTOR METTL14 MCM5 AFF4 MCM6 PERP HMBOX1 MDM2 CCND1 YY1 PMC2040891__F5 UVB acts at both the switch and the switched pathway to trigger UV-induced apoptosis MDM2 BAX PMC3652575__F2 Activation pathway of pDCs responding to viral nucleic acids and negative regulation of the pDC function by surface receptors BTK TLR7 TLR9 IRF7 IRAK1 TRAF6 IRAK4 IL6 CD80 MYD88 PMC6543964__F2 Complement cascade and complement regulatory proteins (CRP) HEL-S-62p CFB CFD THBD CFH CP CFI PMC7699880__F2 Leptin–melanocortin pathway MC4R ARC LEPR SIM1 PMC7071158__F3 Leptin-induced pathways POMC SOCS3 NPY AgRP LEPR MTOR FOXO1 STAT3 PMC8470674__F1 Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives GNE CMAS NANS NANP PMC8464874__F6 L-Plastin Phosphorylation: Possible Regulation by a TNFR1 Signaling Cascade in Osteoclasts LPL SRC TRAF6 RHO PMC3670280__F3 STAT1 as a central mediator of IFNG and TLR4 signal integration in vascular dysfunction TLR4 IRF8 IRF3 TYK2 MYD88 JAK1 IRF-1 PMC6405305__F4 Network modeling of the epithelial-to-mesenchymal transition (EMT) SHH TF PMC1940036__F6 Wnt/Axin1/Beta-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries NODAL PITX2 AXIN1 PMC6405305__F1 Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition HMGA2 TGFBR1 MYC GRB2 TGFBR2 CDH2 BACH1 PMC3960348__F2 Schematic overview of the mTOR signaling pathway with the target position of drugs TSC2 TSC1 PTEN MTOR PMC3960348__F1 Schematic overview of the mTOR signaling pathway with the most important factors and their action TSC2 ULK1 TSC1 PTEN SGK1 RHEB STAT3 PMC4852160__F1 Adenosine monophosphate-activated protein kinase (AMPK) activators for the prevention, treatment and potential reversal of pathological pain TSC2 TSC1 NGF IL6 EIF4E PMC3148828__F4 KEGG pathway: cell cycle CDC20 ATM CDK2 SMAD4 ATR CDK7 PCNA SKP2 PMC9562239__F1 Advances in Biomarkers and Endogenous Regulation of Breast Cancer Stem Cells CDH11 APC GSK3B KLF5 B4GALT5 PTEN RHO CCND3 NRP2 SUFU PTCH1 SHH SMO USP37 PMC3046919__F7 Proposed model of the process of A20 SMAD2 SMAD4 PMC7565722__F6 TRAIL of oncogenes to apoptosis ROMO1 ROS1 BAX PMC10459989__F5 Schematic diagram of the plant hormone signal transduction pathway and its correlation with DEGs in response to B RPS5 RPS2 BAK1 EBP ERF PMC6798329__F6 Activation of AhR pathway by mycotoxins (Myctx) AIP AHR CYP1A1 PMC4914023__F1 Melanosome biogenesis is a typical model for studying LRO biogenesis RAB38 TYRP1 RAB9A VAMP7 RAB32 PMC7961911__F5 Network/pathway analyses: KDM1A is directly linked to the androgen receptor signaling pathway (green) and is indirectly linked to the immune response, DNA damage response, and cancer cell cycle pathway, among others KDM1A DPY30 FOXM1 BLM TFRC TXN CDC45 CCNE1 CHEK2 CLSPN MCM2 ATM CCNB2 HDAC2 CDC2 RAN ATR HMGB2 PCNA PMC10526140__F4 Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology BRCA2 MYC PTEN ATR BRCA1 AMT PMC10296711__F8 Schematic illustration of the TLR/IL1/IRAK/NFKB inflammatory signaling pathway axis IL1A IRAK1 IRAK2 RELA TRAF6 IRAK4 MYD88 MAP3K7IP1 IRAK3 PMC10296711__F5 Schematic illustration of the activation process of TLR receptors and their downstream signaling molecules upon activation forming the TLR-MYD88-IRAK1/4-TRAF6-NFKB/IRF or TLR3/TLR4-TRIF-IRF/NFKB signaling pathways TLR5 TLR9 IRAK1 TRAF6 IRAK4 IL6 CCL2 MYD88 TNF TLR1 TLR10 TLR3 TLR8 LTA TLR7 TLR4 CD80 PMC6482253__F1 Eukaryotic cell metabolism MFN1 TSC2 MFN2 TSC1 PMC549180__F2 ErbB signaling pathway BAD GRB2 SHE CCND1 PTEN MTOR PMC4480226__F1 Immune Responses to HCV and Other Hepatitis Viruses TBK1 PDC TLR7 TRAF3 IRF3 TLR3 MAVS PMC10531306__F2 Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function IGF1 GHR SRC PMC11881607__F3 Deubiquitinases functioning in asthma pathology NLRP3 USP4 USP21 CYLD TRAF3 BARD1 HDAC2 BRCC3 JUNB USP25 TNF GATA3 PMC11881607__F2 E3 ubiquitin ligases inhibit asthma pathology CUL5 NLRP3 CUL4B FBXL19 TRIM21 IL33 TRPM2 IL1B SOCS1 GATA3 ITCH PMC3149764__F3 Emerging roles of JAK–STAT signaling pathways in adipocytes LIF OSM PRL IFNG PMC11881607__F1 E3 ubiquitin ligases promote asthma pathology AMFR MID1 IL25 CBX4 PMC6704453__F8 The Mb maturation process HEL-S-94n AARSD1 CDC37 PMC3380732__F7 Analysis of the cell cycle pathway CDKN2B NFIB SREBF2 CDK4 LMO2 NR1C1 PAX4 PMC9578007__F1 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis FGF21 ACACA EGFR INS AHNAK CCL2 XBP1 IL18 TLR4 PPARGC1A CCL24 IL17A HEL-S-44 EIF4A3 NR1H4 FASN HMGB1 FGF2 TNF NR1C1 LEP LIPE SLC2A4 CPT1A PPARG SIRT1 PMC8721856__F2 Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors KEAP1 SLC7A11 ATF4 EIF2A ATF3 SLC3A2 BAP1 BRD4 PMC9086235__F1 Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors TYK2 JAK3 IL-21 JAK1 IFNG PMC7707178__F2 Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous MVD MVK IPP PMC2831042__F7 Proposed model of neurite outgrowth pathway in postnatal SVZ/RMS-derived neurons RAC1 CDC42 PMC11635660__F2 Transcriptomic analysis of dietary G CDO1 INSIG1 ACLY PMC4837953__F2 Characteristics of the interplay among RIPPLY2, TBX6, and MESP2 and their relation in the notch signaling pathway and L/R axis determination RIPPLY2 NODAL TBX6 MESP2 PMC3638770__F4 Two major pathways to apoptosis BAD ATM FADD BAX PMC6311798__F1 Red arrowhead represents inhibition IGF1 PDK2 INS SMAD4 PTEN INSR PMC11765430__F7 Schematic diagram illustrating the molecular mechanism by which lactate promotes granulosa cell autophagy via the HIF-1A/BNIP3/Beclin-1 signaling pathway BCL2 BNIP3 HEL-S-133P PMC4423646__F1 Ischemia/ reperfusion-induced and sepsis-induced endothelial dysfunction is initiated by increased amounts of reactive oxygen species STAT1 IRF-1 BAX PMC4515436__F4 Short range signalling between the germline stem cells and their niche, which consists of the hub cells and the cyst stem cells EGFR SMO GSC PMC9700707__F6 In silico and in vitro analysis of microRNAs with therapeutic potential in atherosclerosis PLTP LPL NPC2 CD36 PMC8471358__F3A Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives IGF1R IGF1 MTOR PMC6442489__F7 Schematic illustration of SAA attenuating kidney oxidative stress in 5/6Nx rats KEAP1 NOX4 PMC2682636__F4 The comorbidity of HIV-associated neurocognitive disorders and Alzheimer’s disease: a foreseeable medical challenge in post-HAART era CCR5 CD36 PMC8637759__F9 Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting HMGB1 IL6 TNF PMC4443741__F4 CD44 interferes with apoptosis resistance in HSC/LIC MMP7 ERBB4 BAD HGF GRB2 CD44 HBEGF CDC37 HAS1 HAS3 HAS2 PMC9344092__F2 Phagocytic microglia and macrophages in brain injury and repair IL33 ARG1 CD36 PMC5450035__F1 Neuroimmune interface and the role of glia in the pain response HMGB1 CCR2 IL1R1 CCL2 TNF MTOR IFNG PMC6442705__F7 Mechanistic illustration of the effect of alcohol on the dysregulation of genes involving several metabolic pathways leading to alterations in serum metabolomic profiles CTH FGF21 GCA SULT2A1 CYP7B1 SULT1E1 CYP7A1 HEL-S-61p MTR CYP27A1 MAT1A CYP8B1 HNF4A FGF19 pcap PMC9497316__F8 Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes CLCN3 KDR CRYBA2 HEL-S-101 CASP9 CRYGD CRYBB3 MERTK TGFBI CP PMC8427189__F2 Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth POMC CRH TNF PMC6907743__F1 Autophagy during viral infection — a double-edged sword TBK1 CGAS ULK1 ATG12 TLR9 STAT2 FOXO3A IRF9 IRF3 SENP2 MYD88 IRS1 TLR3 STAT1 TUFM TLR7 TRIM32 EIF2A MAVS PMC9588458__F7 Working model of hyperglycemia in DCM ATF4 MAPK10 BCL2 BAX PMC5488809__F2 Cancer metabolism as a central driving force of glioma pathogenesis PIK3CA PTEN TERT PMC6907743__F3 Autophagy during viral infection — a double-edged sword TBK1 ULK1 ATG12 ATG3 IRGM SNAP29 IRS1 DKFZp686F0183 HEL-S-69p TSC2 TUFM EDEM1 EIF2A UVRAG STX17 GBF1 PMC8287779__F2 Exosomes in lung cancer metastasis and clinical applications: an updated review MMP9 MORC2 STAT3 PMC8796122__F2 Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification MYH9 APC RELA GRB2 SRC REL PMC7436330__F1 Red arrow shows the classical pathway of LPS-mediated activation of TLR4 that further leads to pyroptosis and releases of IL-1B and IL-18 IL16 TLR4 GSDMD PMC5635916__F6 Model for how cytosine deamination, base excision repair, and Mlh1-Mlh3 cleavage cooperate to cause R-loop–induced CAG repeat fragility and contractions RAD1 MLH3 PMC1975829__F1 Viral infections: beneficial role of eosinophils ITGAM TLR7 EPX PMC8253640__F2 Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis SESN2 MTOR PMC9387558__F1 Hormone supply to the pituitary gland: A comprehensive investigation of female-related tumors (Review) SST IGF1 GHR GHRH PMC3520616__F1 Upstream events in BCR signaling BTK BCR LYN SYK PLCG2 PMC3368902__F1 Postprandial Regulation of Hepatic MicroRNAs Predicted to Target the Insulin Pathway in Rainbow Trout PTEN MTOR IRS1 PMC6115711__F3 SUMOylation system and TGFB signaling interplay ZEB2 SMURF2 PIAS1 SMAD4 SMO PMC9576590__F5 Senescence-associated secretory phenotype (SASP) ATM MTOR PMC5622153__F3 BACE1-dependent NRG1/ErbB4 signaling pathway involving in the pathogenies of schizophrenia BACE1 NRG3 EGF ERBB4 NRG1 PMC6207918__F10 TGFB/ALK1 signaling at the BBB and regulation of the Slco1a4 gene SMAD4 SMAD1 DKFZp781O1323 PMC5622153__F2 Neuregulins proteolytic cleavage pattern by BACE1 BACE1 NRG3 EGF ERBB4 ADAM17 PMC6333596__F2 Sonic hedgehog signaling pathway SOX2 SUFU PTCH1 SHH CCND1 SMO PMC3137255__F2 A simplified model for Hh signaling in mammalian cells BOC KIF7 SUFU SMO PMC4728015__F4 Galactose-1 phosphate uridylyltransferase (GalT) gene: a novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts IGF1 HEL-S-19 PTEN PMC6611727__F3 Caspases in cell death, inflammation and disease TRADD RIPK3 TNF ZBP1 GSDMD CASP3 NLRP3 RIPK1 CASP9 TRAF2 CASP8 FADD MLKL TAB3 BAX PMC2933570__F1 Coordinated upregulation of cytoprotective genes occurs as a result of Nrf2 activation GCLM GCLC PRX PMC3225028__F2 WT1/EGR1-mediated Control of STIM1 Expression and Function in Cancer Cells EGR1 WT1 STIM1 PMC9411204__F4 Proposed biosynthetic pathway of triptonide (2) from 14-hydroxy-dehydroabietadiene (5) in S. cerevisiae HIST1H1E H1-5 PMC3205852__F10 Schematic illustrating the potential role of integrin B3 (ITGB3) in ROS-induced migration and invasion of colorectal cancer cells GRB2 SRC HEL-S-44 PMC11491057__F3 Epigenetic modulation and tumor immune efficacy HLA-A TBX21 MYC CD40 CCL5 CD80 EZH2 PMC11491057__F2 Tumor immune efficacy by the cGAS-STING pathway APC CD80 PMC4489259__F2 Output of a fictitious combination of gene expression and mutations in version of the Calcium signaling pathway modified for illustrating the examples PLCG1 CHRNA7 PHKA1 ADCY1 EGFR ATP2A1 CACNA1A PLCB1 CALML6 PLN GNA11 TRPC1 CAMK4 CHRM1 PLCE1 BST1 GNAL PLCD3 MYLK PMC11491057__F4 Illustrates the mechanisms of metabolic regulation in tumor immune evasion CD47 MYC CD36 PMC9037156__F9 Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis EGFR HBEGF TNF PMC8255141__F4 Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene TLR4 TREM1 MYD88 TREML1 TNF IL1B CASP5 PMC10844364__F4 Novel acylations act as significant regulators in HCC metastasis AK2 CS ITGB3 IL6 TFAM PMC8869096__F1 Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer IL10 NLRP3 IL18 MTOR DEPTOR MLST8 PMC9356732__F4 Comparative Genomics of the Waterfowl Innate Immune System TH NFKBIA CHUK MAPK13 ATG12 CXCL10 SPOP IL12A TRAF2 PMC9356732__F3 Comparative Genomics of the Waterfowl Innate Immune System CHUK TANK CTSK FOS APP TF PMC6721756__F7 Role of distinct STAT2 and/or IRF9-dependent pathways in the regulation of distinct subset of antiviral and immunoregulatory genes in response to IFNB and TNF STAT1 TYK2 JAK1 PMC8844014__F8 Alpha-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal PLN TNC PI3 BCR HRC MCU PMC10844364__F1 Main functions and metabolic origins of novel acylations CDK2 PHF5A TMOD3 MLST8 PMC10844364__F2 Novel acylations participate in head and neck cancer metastasis HDAC3 RAB27A EGFR ZDHHC13 TG TF PMC10179672__F4 Ligands, receptors, and transcriptional regulators of Hedgehog signaling pathway SUFU SMO PMC10179672__F5 Key components involved in the regulation of activation/inactivation of the canonical or Wnt/Beta-catenin pathway APC PMC4562871__F1 Conceptual barriers to understanding physical barriers IL13 TNF PMC6935754__F1 Hypotheses for the accumulation of amyloidB42 and tau pathology linked to cognitive impairment and epileptogenesis in TLE BACE1 APP ADAM10 MTOR PMC4522091__F1 Simulation of metabolic flux changes in the central metabolism of the redox reaction manipulated strains LDHD CIT HEL-S-162eP PMC5974030__F7 Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice SOX2 HEY2 NEUROG1 PTCH1 GFAP SHH NEUROG2 PMC6975221__F5 KEGG pathway of cardiac muscle contraction (a) and PI3K-Akt signaling pathway (b) BAD MYC PTEN MTOR TRDN RYR2 RHEB RXRA TNC MDM2 HRC CASQ2 C1S PMC8187902__F2 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms APC VEGFA CCNH PTEN RB1 CDK7 CDK6 FZR1 CCNE1 WEE1 CDK2 MDM2 CDK4 CDC2 PMC8187902__F3 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms MAF FOXA1 ERBB2 CDK2 TFF1 EGFR PRB1 CDK4 SP1 MTOR CDK6 PMC9491322__F10 Organic acid metabolism in Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] is controlled by a complex gene regulatory network SI MDH2 PMC6039344__F1 IL-33 signaling RETNLB MAPK3 IRAK4 CCL2 MYD88 MTOR MMP3 CCL24 SIGIRR IL1RL1 CCL17 FLG NOS2 IL4 CSF2 ARG1 JUN SELE CCL11 AREG IL13 FOS IL6 TNF TSLP TMED1 FBXL19 TNFSF11 CDKN2B NFKB1 RELA ABCG1 IL33 CCL20 CCL22 TGFB1 PCNA PMC6945043__F1 Embryonic origin of the E blastomere and simplified diagram of the gene regulatory network for endomesoderm specification in C MED12 POP1 MED1 PMC4531144__F1 Schematic demonstration of PHB-mediated survival or apoptosis responses in multiple cellular compartments of different cell types and molecular mechanism involved PHB2 OPA1 PMC7689594__F6 Sub-network of hub genes related to the disease phenotype of chronic ITP SMC3 LMNA JUN PRKACG PMC4618091__F2 Scheme of biosynthesis of bile acids and of traditional steroidogenesis CYP27A1 CYP11A1 CYP7B1 CYP17A1 CYP21A2 CYP7A1 HSD3B7 CYP11B2 PMC8507042__F1 Metabolic reprogramming in epithelial ovarian cancer F2 PHGDH HK2 STAT3 HEL-S-68p HEL-S-162eP PMC7042886__F2 APP and ΑB Metabolism APP HEL-S-70p PMC8910500__F1 Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling PDK3 FGF2 EGFR PMC8955121__F6 Rotavirus-Mediated Suppression of miRNA-192 Family and miRNA-181a Activates Wnt/Beta-Catenin Signaling Pathway: An In Vitro Study SMAD4 LRP6 CCND2 PMC6095619__F1 cGAS and STING: At the intersection of DNA and RNA virus-sensing networks TBK1 CGAS IRF3 PMC7709568__F5 Pathway enrichment analysis of (A) significantly higher expressed genes and (B) significantly lower expressed genes in T47D cells after glucose deprivation CCNA2 PLK1 RPA3 FANCD2 TRIB3 HEL-S-99n PRIM2 HMOX1 RBBP8 CCNE1 MAF POLE2 POLE POLA1 POLA2 GPX2 MSH6 RAD51 MCM10 H2AX GCLM GSTM5 BRIP1 ATF3 BARD1 FGF13 CDC45 MCM3 MCM5 CLSPN MCM6 MCM2 CDC6 BRCA2 CDK2 DHFR HEL-75 SLC3A2 ATR PCNA SLC5A3 FOXM1 SQSTM1 SLC7A11 TTK CDKN2C TOP2A DBF4 PKMYT1 FEN1 CHEK2 RRM1 RRM2 CCNB1 CCND1 GMNN PTTG1 RBL1 CCNE2 HMGB1 HEL-S-89n FTH1 FTL DNAJB9 RMI1 CHEK1 DKFZp762B153 DDIT3 POLD3 RFC3 RFC4 DNAJC3 HEL-S-125m RFC2 CCNB2 SMC2 ERN1 TYMS FANCA SKP2 ESPL1 FANCG PMC9583871__F1 Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation TBK1 CGAS IRF7 TRAF6 IRF3 TNF STAT1 WEE1 ATM CDK2 CDC2 ATR H2AX IRF-1 PMC2736391__F2 Simplified model of the leptin signaling pathway PC NPY AgRP MC4R TRH MC3R BDNF PMC8294160__F4 Oxyresveratrol Modulates Genes Associated with Apoptosis, Cell Cycle Control and DNA Repair in MCF-7 Cells MOS STOM GEM PMC8793120__F1 BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma BMI1 PMC7600646__F1 Role of dietary flavonoids in the regulation of the Nrf2/ARE pathway in normal cells KEAP1 PMC8877312__F3 Induced Expression of BPV E4 Gene in Equine Adult Dermal Fibroblast Cells as a Potential Model of Skin Sarcoid-like Neoplasia E2F4 SMAD2 SMAD4 STAG1 DBF4 ORC3 CDK7 STAG2 CDK6 CDC45 ORC2 CDC20 MCM2 CDC6 SMC3 CDK2 MDM2 CYC1 CDK4 PCNA SKP2 MYT1 PMC8948490__F1 Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts NF1 RUNX2 RHO CDC42 PMC5548104__F4 Reelin-LIS1-tubulins pathway TUBA1A VAMP2 TUBB TUBG1 NDEL1 NDE1 WDR62 TUBA8 PMC3003620__F1 PI3K/Akt signaling pathway TSC1 RPS6 MTOR RHEB PMC3147278__F3 Cross-talk between TLR4 and IL-1 signaling pathways IL1A TLR4 TRAF6 IL1R2 IL1R1 IL6 PMC5548104__F3 The PI3K-AKT-mTOR signaling pathway BAD CDKN1B MYC VHL FGFR3 PTEN EIF4E MTOR EIF4EBP1 PDPK1 RHEB TSC2 NF1 TSC1 CDKN1A MDM2 STK11 PIK3CA CCND1 EZH2 RPS6 PHF20 PIK3R2 PMC4169452__F2 An Integrated Ontology Resource to Explore and Study Host-Virus Relationships TH TRIM25 MAVS PMC7658045__F7 Distinct cation gradients power cholesterol transport at different key points in the Hedgehog signaling pathway DISP1 PTCH1 SHH SMO PMC8931408__F2 Innate Immune Evasion by Human Respiratory Syncytial Virus TBK1 SOCS3 STAT2 IRF9 TRAF3 TRAF6 IRF3 MYD88 IFNAR1 TRIM25 NOD2 TLR3 STAT1 ISG15 OASL NLRP3 TLR7 MAVS PMC3844930__F1 Defining mitochondrial dynamics MFN1 MFN2 MFF NRF1 BNIP3 FIS1 RHEB OPA1 BAX PMC9494868__F7 TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NFKB signaling pathway IGFBP1 TOP2A PRL PMC11842293__F7 Mechanisms by which OPC mitigates LPS-induced renal tubular injury TNF BAX PMC7865281__F4 Notch-dependent signaling events and signaling crosstalk during the differentiation of MSCs towards osteocytes RUNX2 MSC PMC3844930__F5 Mitophagy pathways PINK1 MFN2 BNIP3 RHEB OPA1 PMC8131909__F1 Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges BTK ALK SMAD2 APC TGFBR1 EGFR SMAD4 SMO CDK4 DKK1 MTOR CDK6 PMC8581356__F1 Immune Evasion Mechanism and AXL SOCS3 CCL5 CCL4 CTLA4 CCL2 AXL CXCR6 SOCS1 CCL3 FOXP3 PMC7060614__F1 Alterations of the propionate pathway in times of acute metabolic decompensation CTH MCC MCEE OTC PCCA NAGS MMADHC PMC2645295__F1 Airway Smooth Muscle Cell as an Inflammatory Cell TRADD TYK2 JAK1 TRAF2 PMC2753863__F1 Examination of Association of Genes in the Serotonin System to Autism TPH1 DDC TPH2 AANAT PMC7780675__F8 Schematic illustrating the role of MGMT in HR signaling in NPC cells BRCA2 RAD51 BRCA1 PMC8056677__F7 Calvin (left) and C4-Dicarboxylic acid cycle (right) in S HEL107 RPE HEL-S-162eP PMC11874147__F3 FAO signaling pathway and ferroptosis in BC GPX4 FADS2 FACL4 SLC7A11 ZEB2 MYC FADS1 IFNG STAT3 PMC11874147__F2 Dysregulation of lipid synthesis and related pro-oncogenic signaling pathways involved in BC development EGFR ABCA1 ACLY HMGCR PMC4071059__F3 Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets? TSC2 EEF2K SMAD2 GSK3B GRB2 SMAD6 SMAD4 TBR1 EIF4E MTOR RHEB GATA4 PMC7979820__F2 Epigenetic mechanisms in breast cancer therapy and resistance DKK3 PTCH1 GSK3B SHH PMC7979820__F4 Epigenetic mechanisms in breast cancer therapy and resistance KMT2C KDM5B FOXA1 EZH2 MLL2 ARID1A PMC2909599__F1 GLP-1 acts by means of the GLP-1-R to stimulate adenylyl cyclase (AC), and thereby cAMP production, and to activate the cAMP-binding proteins PKA and Epac IGF1R BTC IGF1 EGFR GRB2 FOXO1 FOXA2 PMC11912584__F1 HRS-4642 can inhibit KRAS G12D binding to SOS or RAF1 and inhibit downstream MEK-ERK signaling pathways KRAS: Kirsten rat sarcoma viral oncogene homologue SOS: Guanine nucleotide exchange factors (GEFs, e TIAM1 TBK1 EGF BAD MTOR CDC42 PMC8571914__F2 S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes RHO SPNS2 TRAF2 PMC8359440__F5 Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple acyl‐CoA dehydrogenase deficiency AACS HMGCL ACLY PMC4874878__F6 Altogether, our findings are summarized in IL18 TNF IL1B CYP7A1 FASN PMC6826160__F5 ROS‐dependent priming and activation of the intrinsic cell death pathway CASP9 OPA1 PMC4755889__F3 Interconnections between the Hippo and RB/E2F pathways MCM3 MCM6 POLA1 RBBP4 CDC6 RUNX2 LIN52 LATS1 CDC2 LATS2 PMC10813042__F3 Antioxidant mechanism of estrodiol EGFR SRC PMC4755889__F1 Regulation of transcription by YAP/TAZ transcriptional co-factors and the regulation of YAP/TAZ activity in mammalian cells RUNX2 AMOT AREG BIRC5 SMAD2 EGFR APC ARHA LATS1 PAX3 LATS2 MCM6 NF2 TBX5 SHH PMC7400965__F2 Difference between SHARPIN presence and absence in regulating the NFKB signaling pathway TRADD SHARPIN TRAF2 FADD PMC6358228__F1 Canonical pathway network analysis TRH VEGFA PCSK1 TGFB1 PCSK2 PRL GHRH CSHL1 PMC7400965__F3 SHARPIN regulates multiple signaling pathways in tumorigenesis SHARPIN MDM2 PTEN SOX10 PAX3 PMC4152724__F2 Immunoregulatory molecules are master regulators of inflammation during the immune response STAT1 APC ZAP70 GADD45A CD80 IFNG STAT3 PMC4152724__F1 Immunoregulatory molecules are master regulators of inflammation during the immune response APC CD80 IFNG PMC6351787__F5 Hexosamine pathway OGA OGT C6 PMC9132697__F2 Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle IGF1 MARF1 FOXO3A MTOR PMC5892012__F1 TERT levels affect EBV latent/lytic status NOTCH2 TERT BATF PMC5448608__F5 Schema of BTB and CNC homology 2 (BACH2) interaction in the nuclear factor‐KB (NFKB) signaling pathway TRAF6 TAB3 PMC5834263__F11 Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death MTOR HSF1 STAT3 PMC3432834__F2 Two NFKB activation pathways induced by RANK, CD40, and LtB R signaling RELA TRAF3 RELB TRAF6 CD40 TRAF2 LTBR PMC10153643__F2 Thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans PCSK9 LPL LDLR PMC7291112__F1 Roles of gga-miRNAs in host response to infectious bursal disease virus (IBDV) infection TANK SOCS3 SOCS6 IRF2 PMC7917704__F6 HMGA2 is regulated by the RAF kinase inhibitor protein (RKIP) pathway HMGA2 CCL5 SDC2 PMC7917704__F5 HMGA2 induces EMT by activation of different signaling transducers NOTCH2 HMGA2 GRB2 TGFBR3 MTOR HAS2 NOTCH3 STAT3 PMC3110682__F1 Hypothesized mechanisms of physical activity in colon cancer COX2 IGF1 APC PMC6216001__F6 Network generation of CDK1, YWHAZ and PRKDC based on significantly differential genes found between cells with PAX2 over-expression and those that lack that over-expression IGF1R TUBA4A HEL-S-84 VPS37C CASK RB1 SLIT2 CSNK1G1 BMP2K EIF3E PKP2 ATM IKBIP CDC2 ATXN10 PRKDC ADK SPTLC1 HELLS KIF24 MYO9A GAPVD1 AURKA CLK1 GJA1 SMC2 SYK XRN1 HEL-S-93 PPP1R2 PSMD4 TMOD3 ATAD1 PYGL MYO5C RPS6KA6 HEL-S-43 PMC12187357__F1 Microenvironment drivers of the EMT ZEB2 CCL5 CCL18 TNF HIF1A PMC7982393__F1 Physiological and pathological functions of the RAS ATR ACE2 PMC6277881__F4 Subolesin/Akirin function in immune response pathways TNF PMC7268348__F7 MYC and HIF-1 regulate glucose metabolism MYC HEL-S-133P HEL-S-162eP PMC12187357__F5 Signaling pathways responsible for EMT-induced drug resistance in HCC EGF SMAD2 EGFR SMAD4 HRAS MTOR PMC12187357__F4 miRNAs cause EMT-induced drug resistance EP300 APC CXCR4 PTEN CXCL12 PMC4426090__F6 Proteomic Profiling of a Biomimetic Drug Delivery Platform VASP CD99 ARHH TEC JAM3 ARHA ITGA4 RAC1 THY1 ITGAM CXCR4 ERMN JAM2 CDC42 PMC1557825__F4 Ordering and correlation network diagrams for the significant pathways PTGER2 AKR1B10 PTGFR ALDH3A2 PTGER3 PTGS1 CYP26A1 ALDH7A1 PTGER1 EPHX2 ALDH1A2 ALDH9A1 PTGIR PTGIS EPHX1 PTGS2 PTGES PTGER4 HEL-S-53e CYP24A1 PLCB1 CYP2J2 TBXA2R CYP27B1 ALDH2 PMC12187357__F3 NFKB causes EMT-induced drug resistance TWIST1 ZEB2 NOTCH1 TNF PMC4492816__F6 Definition of the early fracture healing pathwaySchematic detailing the role of the early inflammatory pathway in fracture healing CCR2 CCL2 TNF OSM PMC9102269__F9 Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver RAB11A EEA1 PGP ABCB1 PMC9695947__F1 Farnesoid X Receptor as a Master Regulator of Hepatotoxicity CYP27A1 CYP8B1 CYP3A4 ABCG8 ABCG5 CYP7B1 CYP7A1 PMC4638128__F2 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? POLE PARP1 LIG1 PMC8290460__F1 MicroRNA-129 in cancer and non-cancerous diseases (Review) CBX1 Nbla10236 HEL-S-1 MTOR PMC4638128__F4 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? POLE RAD51 PMC3792734__F1 Main biosynthetic pathway of saturated and monounsaturated fatty acids SCD ELOVL6 FASN PMC3863344__F2 Downstream targets of p38 MAPK STAT1 RARA MAX MYC HMGN1 PMC2930200__F1 Molecular machinery of myelin gene transcription in Schwann cells MPZ SOX2 MBP SOX10 PMC10376943__F4 FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway EGF EGFR MTOR PMC3579281__F1 Simplified overview of inflammation-orchestrated signal transduction that induces pro-tumourigenic responses in glioblastoma CXCR1 EGF EGFR IL8RB STAT3 PMC8107475__F1 Abscisic Acid as an Emerging Modulator of the Responses of Plants to Low Oxygen Conditions SNRK ATE1 ERF PMC6873535__F2 Effect of RAS signaling components on neural stem cell differentiation NF1 BRAF PTPN11 RAF1 HRAS PMC6873535__F1 RAS-ERK signaling pathway and associated disorders NF1 CS BRAF GRB2 RAF1 SOS1 PMC2904042__F2 Concurrent deregulation of the top five canonical pathways in retinoblastoma (RB) tumors FANCD2 ATM MRE11A BRCA1 PMC4626012__F1 Role of epidermal growth factor receptor in acute and chronic kidney injury EGFR SRC HBEGF MTOR PMC7218232__F5 Metabolite and miRNA changes associated with 3R4F CS-induced immune response HEL-S-26 ARG2 SRM ACO2 OTC NOS2 ARG1 SAT2 MPEG1 SMS HEL60 PMC8864926__F1 Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate HBD ATF1 PMC3109859__F6 Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States ALOXE3 ALOX12B CYP4F22 PMC6139646__F6 Metabolic pathways impacted by PEPCK in the small intestine of mice CIT MAL PMC8126328__F1 G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma RAB14 LRRFIP2 FLNA ATF2 AKT1S1 PRKAA1 FLNB ARHGAP35 NCK1 PRKCA SRC SND1 HEL114 GIGYF2 PRKCI NCL SET EIF4G1 TSC2 RICTOR TSC1 PAK1 PPP2CA PPP2R5D MYLK RPLP2 MYH9 TH PRKCE HSP90AB1 EGFR PAK4 TLN1 MTOR RPTOR EPN1 MYL12A CAV2 RPS6 ACTN4 JUN ANXA1 MAP2K2 FXR2 AAG1 CRTC2 RAF1 GRB10 EPHA2 CSF1 PXN PMC11506648__F6 AREG’s role in ESCC-MSC interactions AREG FAP MSC EGFR PMC8869630__F1 Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response TBK1 CGAS STAT2 IRF7 IRF9 TRAF3 RIPK3 TRAF6 IRF3 IFNAR2 IFNAR1 ZBP1 RNASEL STAT1 TYK2 JAK1 MLKL MAVS PMC4427618__F2 Coordination of developmental signalling pathways by USP9X EGF RICTOR MIB1 USP9X SMAD4 MTOR SMURF1 ITCH PMC8082835__F7 Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness HEL-S-26 GOT2 GPT2 GLS2 GLUD1 PMC8678479__F2 Pyroptosis: A New Insight Into Eye Disease Therapy NLRP3 KY MYD88 TAB3 PMC11033252__F6 Mechanisms of human NLRP6 inflammasome activation NLRP3 LTA TLR4 NLRP6 TNF GSDMD PMC11033252__F5 Mechanisms of human NLRP3 inflammasome activation and regulation NLRP3 S1PR2 IL1R1 MYD88 TNF CASP8 MAVS GSDMD PMC9117271__F1 Apoptotic signaling in VC ROCK1 TNF HTRA2 FADD BAX PMC6906145__F1 Regulatory pathways for Arid5a under TLR4 signaling TLR4 WWP1 ARID5A STAT3 PMC10253673__F1 Potential mechanisms by which alcohol modulates Alzheimer’s disease (AD) pathology BACE1 CDK5 APP MTOR PMC7219141__F6 Hypothetical signalling pathway showing that dysfunctional TGFB network signalling regulates tissue fibrosis and may play a role in this PCOS-specific insulin resistance and its limited response to exercise training DCN MTOR IRS1 PMC3840259__F9 A summary schematic overview highlights the signaling pathway proposed in the present study COX1 HEL-S-11 PMC5501176__F4 Roles of Autophagy signaling pathway in cancer in type 2 diabetes TSC2 RICTOR TSC1 STK11 PDPK1 RHEB PMC8995973__F2 Pyroptosis by ncRNA: A Novel Research Direction NLRP3 NLRP1 GZMA TNF GSDMC AIM2 GSDMB GSDMD DFNA5 PMC8526866__F7 SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas RBBP4 ADCY1 RBBP7 EZH2 EZH1 SUZ12 EED PMC5501176__F3 Roles of SIRT1 signaling pathway in cancer in type 2 diabetes ATM PPARGC1A NFKB1 VEGFA STK11 MTOR HDAC1 SIRT1 PMC5501176__F2 Roles of mTOR signaling pathway in cancer in type 2 diabetes IKBKB TSC2 TSC1 VEGFA EIF4EBP1 HIF1A SIRT1 PDPK1 RHEB FASN PMC7374064__F6 Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells AGO2 NPM1 PURA COL1A2 MYC APP MTDH RB1 NR1C1 E2F3 STAT3 PMC8403526__F2 SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance EPO IL2 IFNG PMC10536258__F3 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke CXCL1 VEGFA PMC7264673__F1 Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2? IRAK1 TRAF6 IRAK4 MYD88 IL1B TAB3 PMC10536258__F2 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke CNP MTOR GPR39 PMC5868458__F3 Protein expression levels of healthy cerebral cortex cells mapped onto the GBM pathway map from the TCGA data set TSC2 INA GC PMC6275123__F1 Wnt/Beta-catenin pathway APC LRP6 PMC6275123__F3 The IGF2 signaling pathway BAD IGF1R IGF2 PDK2 GSK3B MDM2 GRB2 PTEN MTOR PMC9289111__F6 Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway PTEN MTOR FOXP3 PMC4483763__F5 Key signals mediating progenitor fate decisions during hepatogenesis HGF NODAL OSM PMC4037363__F3 Trafficking of endosomal Toll-like receptors IRF7 MYD88 PMC4901281__F7 In-depth comparative transcriptome analysis of intestines of red swamp crayfish, Procambarus clarkii, infected with WSSV IL10 PIM1 EPO MYC IL6 CBL PMC8427320__F3 Potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine SRC PTEN CDH2 HIF1A MTOR BAX PMC8269350__F1 Possible Link between SARS-CoV-2 Infection and Parkinson’s Disease: The Role of Toll-Like Receptor 4 CD14 TLR4 TRAF6 MYD88 PMC3082271__F5 NVN for Putative CHS-Mediated (CHS4) Medicarpin Biosynthesis.Nodes in the network resemble individual genes, and the connecting edges represent coexpressed links MTR NEU1 STS PMC8781535__F2 Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 IFNLR1 PMC7804410__F4 The selected miRNAs target genes in KF-Tx cells BAD NRAS PTEN RAC1 INSR RXRA PRKCA PI3 BCR RELA CASP9 SYK HEL-S-93 RBL2 CD19 PMC5840987__F1 Canonical and non-canonical Wnt signaling pathways.(Left) Unstimulated Wnt pathway results in constitutive Beta-catenin degradation APC GSK3B LRP5 LRP6 ARHA RYK ROR2 RAC1 JUN PMC12042445__F8 Antioxidant and mitochondrial protective effects of EPS in PD KEAP1 GCLC BAX PMC3273421__F2 Myostatin and activin signaling in muscle SMAD2 SMAD4 PMC4817802__F4 Role of histone PTMs in DNA damage repair RNF24 RNF31 RNF38 RNF2 BRCA1 RNF32 RNF168 RNF8 RNF20 RNF26 ATM RNF34 RNF25 H2AX RNF39 PMC1900132__F1 HCMV MIE promoter/enhancer and its cis-acting elements YY1 ERF SP1 PMC3947622__F1 Molecular programming of B cell memory BCR GC PMC8117345__F5 DNA Repair Repertoire of the Enigmatic Hydra XPC ERCC1 XPA DDB2 DDB1 PMC8797306__F2 Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis E2F4 CDK2 SMC3 APC SMAD4 DBF4 CDK7 ORC2 SKP2 PMC7448422__F7 Schematic diagram of the potential mechanism underlying the miR-590/LRP6/EMT axis in ESCC LRP6 CDH2 PMC7518857__F4 Hedgehog signalling is initiated at primary cilia SAG PTCH1 GPR161 SMO PMC7518857__F6 INPP5E regulates Hedgehog signalling via ciliary phosphoinositide metabolism GPR161 SMO INPP5E PMC9229940__F3 Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review VIT PMC7987878__F1 NRs promote tolerance increasing recognition and degradation of apoptotic cells MERTK DKFZp686F0183 CD36 PMC9548020__F5 Treatment effects of the EGFR pathway drugs on head and neck cancer stem cells EGF EGFR GRB2 CD44 BDNF PMC5931986__F3 Nucleolar response to nuclear or nucleolar DNA damage CDC14B NCL PLK1 NPM1 ATM APC MDC1 POLL ATR POLI PMC3941198__F1 Milk lipid secretion: recent biomolecular aspects DGAT1 GPAT4 ADFP LPA PMC9259951__F2 Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms MLXIP PNPLA3 NLRP3 GCKR TLR4 IGF1R MLXIPL NFAT5 SLC2A9 STC1 ABCG2 NR2A2 PMC4361071__F1 Notch signaling pathway.(a) Schematic depiction of mammalian Notch receptors and DSL ligands NOTCH2 EGF NOTCH4 NOTCH1 FURIN NOTCH3 PMC3514827__F1 Using components of the Vitamin D pathway to prevent/treat colon cancer GIG8 NR1i1 APC DKK1 ID1 TCF4 PMC7692253__F2 Identified B lymphocyte‐induced maturation protein‐1 (Blimp‐1) targets in mononuclear phagocytes (MNPs) SIGLEC1 CCL8 MAFB IFNA1 CTSS IRF8 HEL-S-2 CXCL10 NLRP12 CCL2 IRF4 PMC8129319__F5 WW45 inhibits breast cancer cell proliferation by the Hedgehog signaling pathway HHIP SHH SMO PMC4322894__F1 CXCL12 is highly expressed in tissues like lungs, liver, and bone marrow and is also secreted by tumor and stromal cells BAD CXCR4 PPA2 RHO CXCL12 CRK CDC42 PMC16561__F6 The signaling pathway from the upstream protein-tyrosine kinases, Lyn/Syk/Btk, to cytokine gene expression through intermediate signaling proteins, PKCBI/JNK BTK LYN SYK PMC9632461__F6 CA regulates the mitochondrial quality and enhances the vitality of LMSCs MFN1 PINK1 MFN2 FIS1 PMC3605164__F2 New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic Beta-cells APC GSK3B AXIN1 LRP5 LRP6 PMC8924518__F3 Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora FGF21 CPT1A NR1C1 PMC2997801__F1 Positioning NFKB in multiple myeloma PI3 IGF1R IGF1 CYLD TRAF3 CD40 TRAF2 LTBR STAT3 PMC12028784__F7 This study TLR4 VCAM1 IL6 TNF PMC4905465__F6 Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome ALB UNG PAX3 CEBPB IFNG RARA RARB LY6E AHR BASH CD2 IL2 JUN LY6D CD3E LY6K FOS VEGFA TNF CD8A NR1C1 LY6H TEX101 HLA-C CD27 TGFBI PMC8158527__F1 Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering RUNX2 BMP2 SMAD2 SMAD4 SP7 SMAD1 DKFZp781O1323 PMC9157711__F2 Hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA MSL2 APOBEC3B FOXA1 DLL4 NOTCH1 EZH2 APOBEC3C PCNA STAT3 PMC3103888__F1 TIRs signaling pathway TBK1 TLR5 TLR7 IRAK1 IRF3 IL6 MYD88 TLR1 TLR10 TLR3 PMC2432088__F1 WNT SIGNALING PATHWAY: AGING GRACEFULLY AS A PROTECTIONIST? GSK3B RHO PMC8180168__F1 Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy COX2 TFF3 MUC2 PMC6284771__F8 Schematic model illustrating that miR-10b mediated function in osteogenic and adipogenic differentiation of hADSCs RUNX2 SMAD2 SMAD4 PMC7161552__F10 Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP‐1 and HER2 expression and converted MCF7 breast cancer subtype NRP1 EGFR CCNB1 PTEN PMC6175900__F2 Evolutionarily selected pathway (ESP) map PIK3R1 CNTN1 FLNA ALB FOXQ1 MARK1 NF1 POLE GOLIM4 SAFB HTT SPTBN1 NOTCH1 MAPK1 SPTAN1 ARHGEF17 GIGYF2 THRAP3 NCOA6 UBE2D2 CDK8 IRS1 POU4F2 PRKCB HSPG2 STK11 IL2RA TRIM27 THADA ZIC3 CUL9 CRB1 PLCG1 USP4 EPHA3 HIPK2 UBR5 SETD1A MAP2K3 ACTL6A ERBB4 NF2 KAT8 ACO2 USP9X STK11IP UBR4 TFAP2A AKAP9 CCNE2 SRCAP PDGFRA HECW2 MTIF2 NR3C1 KLF5 HUWE1 MED21 PTPRF MYO7A BCL6 PTPRC ARID1B CREBBP ERBB2 NCAPG TYK2 TUBB4A VAMP7 BOC IL3RA GRIP1 TRIM7 SNRPN RANBP2 TXN AGO1 SMARCA4 POLA1 PTK2B HEL114 EN1 RNF39 PRRC2A NELL1 FRAS1 AKAP12 Nbla10317 SALL1 SNX9 HRAS PAN2 SAFB2 APOB LAMA1 KMT2A IGSF21 BRCA2 KMT2B ATR MAST1 MLL2 ZNF560 RB1CC1 MAP9 CYLC2 FAM47B BRAF PPFIBP1 DYSF RUNX2 TTK EEF1A1 TRRAP PTEN LATS1 TTN MTA2 DMD PTPRB ATM MED1 USP42 PRKDC UBE4B GBF1 NBEAL2 CEP135 NUAK1 NFE2L2 FGFR3 CD44 NRG1 NMT1 TTI1 MAP2K1 CLTCL1 S100A8 PIK3CA GRB10 WDR82 RPL5 PIK3R2 PMC6036173__F2 Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage TLR4 EGFR GRB2 SRC CDK4 HRAS MTOR COMP CDC42 PMC5114520__F1 Double-strand break can be repaired by cNHEJ with minimal end processing BRCA2 RAD50 RAD51 PARP1 LIG1 MRE11A BRCA1 PMC3095949__F3 Functional pathway analysis of the 28-gene prognostic signature using Ingenuity Pathway Analysis INPPL1 CHUK SLC25A5 HSP90AB1 CSTF1 NR3C1 DBF4 WRN PMS2 S100P GBP1 UBQLN2 DUSP5 TMEM97 HSPG2 MMP12 RRM2 BIK KLRK1 RAD52 TM4SF1 MSH2 SP1 FCAR PMC7084279__F7 Detailed analysis of the 13 out of the 23 screened genes in “monoamine GPCRs” pathway HTR6 HTR1B DRD1 DRD2 DRD4 HTR1F CHRM5 HRH1 DRD5 CHRM2 HTR1E HRH2 ADRB1 ADRB2 HTR7 HTR5A HTR4 CHRM4 DRD3 CHRM3 CHRM1 HTR1A ADRA1A HTR2A HTR2B ADRB3 HTR1D PMC7397304__F6 Possible antioxidant signaling pathways regulating dexamethasone-induced muscle apoptosis by quercetin BAD SMAD2 FOXO1 BAX PMC6073502__F3 Interaction of proteins 3 days after hyperoxia HEL-S-2a SUMO3 HEL-S-269 FBP1 ALB HEL-S-34 ADD2 ENO1 HEL-S-100n HEL-S-32 PS1TP5BP1 PMC8548344__F2 Crosstalk between Hedgehog and other pathways in the intestinal tract NUMB SMO WNT2B NOD2 PMC8548344__F1 Paracrine Hh signalling in the mammalian intestine HHIP SUFU GSK3B SMO GAS1 PMC6073502__F2 Proteins with influence on cell-death related signal transduction (green/light green: up-regulation, red/light red: down-regulation) GDA HEL-S-34 ADD2 ALB ENO1 RPSA HEL-S-32 PS1TP5BP1 STOML2 KRT2 HEL-S-102 HEL-S-2a HEL-S-269 HEL-S-100n PPP2R2A MEP1A PMC6073502__F1 Ingenuity pathways analysis (IPA) functional network generated for data of NH0-, NH3-, and NH7-groups SUMO3 MAPKAPK2 CS MAP2K4 FOS GDA MAPK10 HEL-S-101 hCG_2044782 IL6 HEL-S-32 STOML2 KRT2 INSR HEL-S-102 HEL32 IGFBP1 PLA2G3 SREBF2 SURF1 MEP1A IL1B PBR CYCS PMC9310475__F1 Which patients are prone to suffer liver metastasis? A review of risk factors of metachronous liver metastasis of colorectal cancer BRAF APC GC EGFR GRB2 MTOR PMC11607765__F1 Clinical role of Aldehyde dehydrogenase-1A1 (ALDH1A1) in pancreatic cancer GSK3B SRC HEL-S-53e PMC4899241__F6 Biological function of extracellular HMGB1 is redox dependent HMGB1 CXCL12 TIRAP PMC8981326__F5 Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation MYB RUNX1 OGA EVI1 B4GALT4 FUT9 ST3GAL6 FUT7 GATA1 PMC3187860__F1 Brain Arteriovenous Malformation Pathogenesis: A Response-to-Injury Paradigm SMAD2 ENG EPHB4 PMC5450331__F1 Signaling pathways of TLRs include MYD-88 independent and MYD-88 dependent pathways TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR3 TLR7 TLR4 FADD PMC7251742__F9 Hypothetical scheme furtherly illustrates the mechanism of which polydatin improves osteogenic differentiation of hBMSCs via stimulating the expression of TAZ in the BMP2-Wnt/Beta-catenin pathway RUNX2 BMP2 APC DKK1 PMC5954114__F2 GAS6/TAM signaling pathway GRB2 PMC5954114__F1 GAS6 and representative TAM family receptor EGF GLA PMC8397419__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway MSC LATS1 LATS2 PMC10138370__F6 GCN2/eIF2A/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet PSAT1 TES SHMT1 PSPH HEL-S-51e PHGDH TF PMC4878851__F5 Lifecycle of cardiac Nav1.5 and potential phenotypic modifiers CAV3 TBX5 SCN5A FOXO1 NEDD4 PMC4615692__F1 Bile acid metabolism and signaling in cholestasis, inflammation and cancer CYP27A1 CYP8B1 CYP7B1 HSD3B7 PMC4125208__F4 Ingenuity pathway analysis (IPA) revealed TGF-beta signaling as the top “connected” network of differentially methylated candidates in HDM-exposed group PLCL2 BMP3 P4HA2 SMAD2 MSR1 UNC93B1 IL36B CREBZF SLC25A12 PDE10A CARTPT TRPM2 SKI PMC3368606__F2 Assembly of targeting patches and inside–out orientation of the secretory pathway RHO CDC42 PMC5752491__F3 Integrated analysis of chromosome copy number variation and gene expression in cervical carcinoma ORC6 APC INS SMAD4 ORC3 CDK7 CDC45 ORC2 CDC20 CDC6 ATM CDK2 ORC1L ATR PCNA SKP2 MYT1 PMC3801100__F1 RSK isoforms control motility and other aspects of tumor cell invasion and metastasis VASP RHO JUN PMC9200208__F3 Low-dose tissue plasminogen activator in patients with refractory hypoxia due to presumed microthrombi in pulmonary vasculature in coronavirus disease 2019: A case series and review of the literature PLG GLA PMC10266771__F1 Proposed mechanism for the regulation of NRAS mutation-driven hematopoietic malignancies involves the CBL/JAK2/RAB27B signaling axis NRAS ZDHHC9 RAB27B CBL PMC9681929__F3 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression RNASEL MYC BCL2 MTOR PMC4278301__F1 Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans NAAA GDE1 PC FAAH PTPN22 PMC7312468__F1 The MNK1/2-eIF4E axis NF1 BRAF NRAS PTEN EIF4E MTOR PMC9181879__F1 Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways TSC2 TSC1 SMAD2 APC SMURF2 EGFR GRB2 PTEN RHEB PMC9681929__F2 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression USP15 STAT2 SPOCK1 PPP1R10 CNOT1 MEF2C FNDC3B PMC6800061__F2 TARGETING INFLAMMATION IN METABOLIC SYNDROME LTA VCAM1 LPL LTB LDLR GPIHBP1 TG PMC6445151__F3 Differential network for the pathway “Signaling by NOTCH1” in the lateral compartment MAML1 KAT2B RBPJ DTX1 JAG2 UBB UBC CREBBP EP300 MAML2 NOTCH1 SNW1 ITCH PMC3967171__F2 Sex hormones and SREBP selectively regulate expression of Aldh1 ALDH1A3 HEL-S-53e ALDH1A2 PMC7608746__F1 SPRED proteins and their roles in signal transduction, development, and malignancy GRB2 SPRED1 PMC6912516__F2 Schematic representation of main ACVR1 signal transduction BMPR2 ACVR1 ACVR2B ACVR2A RHO SMAD1 DKFZp781O1323 PMC6445151__F4 The differential network for the pathway “InlA-mediated entry of Listeria monocytogenes into host cells” in neuroblastoma tumors between HR and non-HR patients UBC RPS27A SRC CTNND1 UBB PMC4010328__F5 TOB1 was involved in regulation of tumor growth and metastasis via the PI3K/PTEN signaling pathway EGF TOB1 CCND1 PTEN PMC7752859__F15 The immunomodulatory activity of Ligilactobacillus salivarius TUCO-L2 isolated from llama (Lama glama) milk in porcine intestinal epithelial (PIE) cells CD14 CCL8 FOS CXCL5 IRAK1 CXCL10 IRAK2 CXCL8 TRAF6 IRAK4 MYD88 TLR4 SIGIRR CXCL9 JUN IL1B CXCL11 PMC4704494__F3 Chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells PTEN PMC9589297__F4 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects SMAD2 TGFBR1 TRPM7 PMC9589297__F5 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects TGFB1 STAT3 PMC6128439__F6 mTOR pathway RS1 ULK1 TSC1 PC ELF3 EIF4E RPS6 MTOR EIF4B RPTOR RHEB INSR PMC6674869__F8 Intracellular signaling pathways downstream of p75NTR and TrkA in sensory neurons NGF TRPA1 TRPV1 PMC316957__F9 How ECSIT may participate in Toll/IL-1 signaling TRADD TRAF5 TRAF6 ECSIT MYD88 TNF TRAF2 PMC4299612__F2 Regulation of Toll-like receptor (TLR) signaling during bacterial lung infections TBK1 CXCL1 IRF7 TRAF3 CD44 CXCL2 IRF3 MYD88 TLR1 TLR4 CYLD TIRAP TAB3 PMC2649968__F4 Participation of DNA repair in the response to 5-fluorouracil SMUG1 MSH6 MSH2 ATR PMS2 PMC5548615__F1 Emerging role of PI3K/AKT-mediated epigenetic regulation in cancer PML EZH2 PCNA PMC5641208__F1 S100A4 in cancer progression and metastasis: A systematic review APC LRP5 MTOR S100A4 PMC3375057__F2 Neurotrophins, the ERK MAP kinase signaling cascade, and GSK-3 BAD MAP1B GRB2 BDNF PMC8043969__F1 Germline Variants that Affect Tumor Progression GNA11 GRB2 CIC PIK3CA PTEN MTOR CTSW RBFOX1 PMC6800568__F1 Innate immune mechanisms in SLE CGAS TLR7 TLR9 CXCL10 TREX1 DNASE1L3 IRAK4 MYD88 IL1B PMC5581236__F7 SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling HEY2 DLL4 SENP1 NOTCH1 SUMO1 HES1 PMC3418056__F5 Postulated interactions between 20-HETE and RAS in the vascular endothelium EGFR PMC5412423__F6 Ceramide metabolism in desipramine-pretreated mice undergoing septic cardiomyopathy ASAH2 SGPP1 SMPD2 PPP2CA SMPD1 CERS5 SPHK1 DEGS1 SPHK2 SMS CERS2 PMC3197858__F1 Fatty acid synthase as a potential therapeutic target in cancer ACACA ACLY FASN HEL-S-5 PMC2592794__F1 Monosodium urate (MSU) crystals activate monocytes via the Toll-like receptor (TLR) pathway and the inflammasome CD14 TLR4 MYD88 IL1B PMC84916__F8 The mechanism of regulation of PLCG2 tyrosine phosphorylation and activation by LAT FYN LYN GRB2 SYK PLCG2 LAT PMC7895520__F7 Mechanism of the protective effect of spermine against high glucose-induced diabetic podocyte injury SQSTM1 MTOR DKFZp686F0183 PMC11050262__F8 Gene expression changes in GO terms: (A) base excision repair, (B) mismatch repair, and (C) homologous recombination pathways in response to high–THC extract #18 compared to DMSO control in the HT–29 CRC cell line PALB2 PC MEI1 ATM BLM BRCA2 MSH3 MSH2 COMP RAD51B PMC6443116__F7 Localized decidualization in the cycling human endometrium PTGIS IGFBP1 PTGES PRL PMC3091668__F4 Putative TLR signal pathway TBK1 IRF7 IRAK1 TRAF3 TRAF6 IRF3 MYD88 TLR1 MAP3K7IP1 TLR3 TLR8 BTK TLR7 TLR4 SIGIRR TIRAP MAVS PMC3913210__F2 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction TCTN2 TCTN1 GPR161 RING1 ARL13B BBS7 SUFU EVC2 PTCH1 GLI3 DYNC2H1 EVC IFT25 SMO RAN PMC3913210__F1 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction BOC CDON KIF7 SUFU PTCH1 GPR161 EVC SMO PMC3091668__F5 Putative TCR signal pathway CSK ATF2 CTLA4 ITK FYN BCL10 LCK ZAP70 GRB2 RAF1 CSA2 LAT CDC42 PMC11987372__F2 Expression and mechanism of action of chemokine family members in PNI CXCL1 CCR2 CX3CR1 CXCL5 ZNF382 CCL7 PTEN CCL2 MYD88 MTOR XBP1 CXCL13 NLRP3 TLR4 SETDB1 LIF IL8RB ATF3 CXCL2 S100A9 GAP43 HDAC1 TLR3 CXCR4 S100A8 CXCL12 PMC3035594__F3 Integrated view of Wnt pathway MYC DVL2 ARHA CSNK1A1 PPP2R1B JUN NKD2 PMC7870078__F5 Identification of differentially expressed genes involved in amino acid and lipid accumulation of winter turnip rape (Brassica rapa L.) in response to cold stress AGXT AASS PMC9530455__F4 mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma PYY NR1A2 PMC7771966__F1 Identification of UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1/2 substrates ENPP1 ERO1B HGF ALG13 PLOD1 FUCA2 SLIT2 PLOD2 ALG1 IGF1 ALG3 ALG12 ALG6 ALG10 PMC6906582__F1 Toll‐like receptors (TLRs) and their downstream signaling IRF7 IRF3 PMC11965705__F1 Important pathways and their functions in pancreatic ductal adenocarcinoma EGF EGFR GRB2 PTEN MTOR PMC4032125__F7 Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program TF PMC2929006__F5 Genetic basis of kidney cancer: a metabolic disease TSC2 FLCN BAD TSC1 FNIP2 FNIP1 PTEN PMC6906582__F4 Viral RNA sensing proteins and their downstream signaling RNASEL ELF2 OAS3 IRF7 IRF3 PMC7291824__F4 Ingenuity Pathway Analysis of gene networks NUDT12 DOK3 IL21R SYNE2 RNF11 SULF2 LAT2 PFKFB4 MKS1 STAT5B IFNG GSTT1 GAREM1 BCR ULBP3 ZHX2 FCMR MRAP NAGA FUT6 SLAMF7 CDC42EP1 HLA-B AURKB CD27 RPS6KA1 CD151 IGFBP1 PGC JCHAIN ASH1L CYB561 TNFRSF17 AGRN CTDSP2 MFGE8 PHLPP2 EMILIN1 JADE3 DUSP15 COPA N4BP3 VPS36 TFCP2 JMJD1C TLR8 ZC3HAV1 BTK MGRN1 YTHDF1 TLR7 A4GALT SOCS7 ABCC6 EAF2 PCDH10 CDC14B DEDD HSPA12B SEMA3B CD79B ID1 CXCR3 CARD9 MAP2K1 PTPRH OGT TXNIP HVCN1 GGTA1 PMC3842494__F8 The proposed role of high CORT levels on the proinflammatory response triggered by LPS and related to MAP kinase–NFKB pathway in rat brain IL16 TLR4 GC IL1B PMC9369058__F6 Spotlight on Exosomal Non-Coding RNAs in Breast Cancer: An In Silico Analysis to Identify Potential lncRNA/circRNA-miRNA-Target Axis LEP INCA1 BRCA2 PTEN MTOR BOK PMC3624394__F4 Comparative analysis of NOTCH signaling pathway components in calcium-differentiated 8E6-iHFKs and GSI-treated C-HFKs by qRT-PCR NUMB JAG2 LFNG MFNG DLL3 NOTCH3 ADAM17 HES1 HES5 DLL4 MAML2 NOTCH1 SNW1 NCOR2 NOTCH2 MAML1 NOTCH4 RBPJ PSEN2 DTX1 HDAC1 HEY2 EP300 PSEN1 ADAM10 PSENEN PMC9671940__F2 Growth stimulation expressed gene 2 (ST2): Clinical research and application in the cardiovascular related diseases IL33 TRAF6 IRAK4 PMC9107782__F6 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy APC LRP5 LRP6 PORCN DKK1 AMN PMC8396260__F9 Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NFKB Signaling through PTEN Activation in Hepatocellular Carcinoma PTEN CDH2 PMC9107782__F1 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy LEF1 APC GSK3B LRP5 LRP6 PORCN DKK1 PMC8934553__F7 LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway LECT2 MTOR PMC4743122__F1 Schematic illustration of the mechanisms impairing VEGF-A/VEGFR-2 angiogenic signal in SSc FLI1 NRP1 VEGFA PMC2515871__F2 Roles of cis- and trans-Changes in the Regulatory Evolution of Genes in the Gluconeogenic Pathway in Yeast PCK1 FBP1 MDH2 PMC9516650__F1 Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer BRAF EGFR PIK3CA RAF1 MTOR PMC7779046__F2 The ‘Hedgehog Signaling Pathway’ page includes a description of the pathway, links to sub-groups and other related gene groups RET SMO LAT PMC10922197__F9 Mechanism by which NBP inhibits osteoclastogenesis is demonstrated CTSK KEAP1 NFATC1 FOS HEL-75 TRAF6 ACP5 PMC6586838__F2 Association between miRNAs of interest and their predicted targets in the insulin signaling pathway (A) and Type II diabetes mellitus pathway (B) BAD PDK2 GSK3B INS EIF4E MTOR CRK FOXO1 RHEB INSR CBL MAFA TSC2 TSC1 GRB2 PMC2810358__F2 Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas SYNE2 NASP SMARCC2 FEN1 RFC2 SMC1A MCM5 MCM2 SMC3 MSH6 CCND1 MSH2 SMC4 NEK9 SUPT16H PMC7892432__F2 Mechanism of pyroptosis affecting endothelial cells in ALI NLRP3 HMGB1 CGAS TLR4 GSDMD PMC7892432__F1 Mechanism of pyroptosis affecting alveolar macrophages in ALI NLRP3 HMGB1 CGAS TLR4 MYD88 GSDMD PMC8911031__F1 Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor SPHK2 LPCAT1 SPTSSA HEL-S-5 PLSCR4 PTDSS1 DGKE LIPG LPL CERS5 PLA2G2A PTDSS2 PNPLA2 CERS2 SGPP2 FASN PMC8494658__F3 Where are we now? Emerging opportunities and challenges in the management of secondary hyperparathyroidism in patients with non-dialysis chronic kidney disease CYP27A1 VIT CYP24A1 CYP27B1 PMC6434466__F7 Osteopontin (OPN) stimulated monocyte chemoattractant protein 1 (MCP-1) production and migration of monocytes CD14 TLR4 LBP TRAF6 MYD88 CSA2 PMC4390087__F5 Beyond Mitophagy: Cytosolic PINK1 as a Messenger of Mitochondrial Health PINK1 FUNDC1 BNIP3 OPTN PMC6372909__F1 Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer EREG EGF HRG BTC AREG HBEGF MTOR TGFA PMC4194117__F1 SIRT2 controls the pentose phosphate switch SIRT2 SIRT1 PMC5415203__F6 Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency TBK1 CGAS CARD9 RAD50 IRF3 MRE11A PMC3356999__F1 Fatty acid regulation of hepatic lipid metabolism FADS2 SCD ELOVL5 FADS1 ELOVL6 ELOVL2 FASN PMC6803550__F7 Model illustrating metabolic processes AFP PC IMPACT MTOR PMC5487993__F9 Paraquat hijacks the pentose phosphate pathway to induce oxidative stress and cell death CS OGDH HEL107 HEL-S-68p HEL-S-162eP GLS PMC7412275__F2 Entry mechanisms of Old World (OW) and New World (NW) arenaviruses CD63 EEA1 NRP2 PMC6007949__F6 CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia CD300A MTOR PECAM1 BAX PMC3100327__F1 De novo Biosynthesis of Biodiesel by Escherichia coli in Optimized Fed-Batch Cultivation PDC FADD HEL-S-5 PMC4521418__F3 Brca1 pathway is involved in microglia from hSOD1G93A mice VEGFA ATF1 XPC DDB2 BRCA1 RBBP8 IFNG STAT1 IGF1 ATM BRCA2 CCNB1 CCND1 MSH2 ATR PCNA NFYA TERT PMC2760836__F2 New concepts in herpes simplex virus vaccine development: notes from the battlefield PDC MYD88 PMC3871878__F2 Hypoxia inducible factor pathway inhibitors as anticancer therapeutics VHL MTOR PMC10931690__F9 Diagram depicting the mechanism of neuroprotective effect of siponimod/BAF312 FGF23 TNFRSF4 CXCL5 CXCL10 CCL20 PMC5741702__F2 Localization of the polycystic kidney disease (PKD) proteins, the pathways implicated in its pathogenesis, and putative therapeutic targets PC GANAB PRKCSH MTOR GLA SIRT1 SEC63 PMC6170780__F4 Prediction of antiviral targets [reactions] from single-reaction perturbations in a virus-optimized system for CHIKV, DENV and ZIKV OMP PMC7409333__F1 Sphingolipid metabolic pathway (plus five sphingosine-1-phosphate receptors) SGPP1 SGMS1 CERT1 UGCG ACER1 ACER3 SPHK1 DEGS1 CERK KDSR PMC5702304__F3 Overview of human TLRs activated by exogenous and endogenous ligands, such as fragmented DNA from necrotic cells; adapted by permission from Macmillan Publishers Ltd, Nature Reviews Gastroenterology and Hepatology, 2006, vol TLR4 IRF7 TRAF3 IRF3 IRAK4 MYD88 TLR3 TIRAP TAB3 PMC4730344__F4 Induction of DNA repair by EGFR signaling ATM BRCA2 EGFR RAD51 PRKDC BRCA1 PMC4730344__F2 Cell death pathways after irradiation APAF1 CDK2 BCL2 CDK4 RB1 ID1 FADD CDK6 BAX PMC9370344__F7 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants ACCS PDC FH ENO1 ACLY HK2 SDHB PMC5071566__F8 Modulation of host AKT pathway by L FOXQ1 GSK3B PMC3260274__F5 Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer PTEN PMC4778253__F4 Mesenchymal and endodermal signaling events NOG SOX2 FGF10 SHH WNT2B EPHB3 PMC6949159__F5 KEGG pathway: CELL CYCLE (A) and P53 SIGNALING PATHWAY (B) TSC2 AIFM2 SIAH1 PERP ATM MYC MDM2 PTEN ATR SKP2 MYT1 PMC8896082__F1 Effects of the probiotic cocktail on modulation of the NF-kB and JAK/STAT signaling pathways involved in the inflammatory response in bowel disease model IRAK4 JAK3 MYD88 NOD2 TIRAP PMC8514763__F3 Non-Coding RNAs Inducing Drug Resistance in Ovarian Cancer: A New Perspective for Understanding Drug Resistance NLK BAK1 CIC ETV4 SFRP1 LATS1 PTEN TNF MLSN2 LATS2 STAT3 PMC4501477__F4 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity RNF168 RNF8 ATM TOPBP1 MDC1 ATR PMC12025106__F3 The activated PI3K/Akt/mTOR/c-MYC pathway in metabolic reprogramming to dietary methionine sources TSC2 TSC1 PTEN RHEB PMC4501477__F3 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity RNF168 RNF8 ATM TOPBP1 ATRIP MDC1 ATR PMC7312541__F1 Canonical Wnt/Beta-catenin pathway APC GSK3B LRP5 LRP6 PMC12025106__F1 Helicobacter pylori infection in methionine metabolism PMC8539574__F2 Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers OGA OGT GNPNAT1 PMC7407016__F1 Regulatory circuits driven by liganded ER-alpha for DNA stabilization (A), cell proliferation (B), and fuel supply (C) IGF1R EGFR MTOR IRS1 BRCA1 PMC6857900__F3 The Links between FTO and Colon Cancer NPY CCND1 STAT3 PMC8192426__F1 Contraction in airway smooth muscle (ASM) ARHA RHO STIM1 PMC9396278__F7 Novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia ANGPTL4 PMC6857900__F2 Simplified Version of the Canonical Wnt/ Beta-Catenin Pathway APC GSK3B PMC4874655__F3 COLORECTAL CANCER BRAF ERBB2 ERBB3 APC NRAS LRP5 TGFBR2 SMAD4 PTEN FZD10 PMC2815016__F4 Activation of the NFKB signaling pathway by farnesol is related to ER stress EIF2A CXCL3 TRAF2 PMC8313979__F3 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis CHST11 TH MHC2TA ATF2 ST8SIA2 DSEL JDP2 B3GNT5 IRF4 MAN1A2 CREB3L4 FLI1 CSGALNACT1 CHST3 RUNX3 ST8SIA4 UST FUT4 TCF7L2 CHD2 MGAT5 MGAT1 ST8SIA1 FUT7 ADNP MEF2C TF ST6GAL1 PMC2815016__F3 Farnesol induces ER stress and activation of the unfolded protein response ATF4 EIF2A PDIA4 TRAF2 XBP1 PMC8313979__F2 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis TF ST6GAL1 PMC6966677__F6 Cell proliferation and metastasis of gastric cancer by modulation of VGLL1 expression and activity LEF1 VGLL1 MMP9 TEAD4 TCF4 PMC7957263__F1 Signalling pathways DKK4 involved in different kinds of cancer APC ARHA DKK4 PMC8688647__F6 Network map of Elabela signaling pathway in physiological and pathological conditions COL3A1 FOXO3A MMP9 MAPK3 CCL2 TNF COL1A1 SIRT3 CASP3 MMP2 PIK3CA BCL2 HEL113 CYCS BAX PMC8688647__F5 Network map of Elabela signaling pathway in physiological and pathological conditions DKFZp686L0365 PMC8688647__F2 Network map of Elabela signaling pathway in physiological and pathological conditions REN FOXM1 MAPK3 POSTN ATF1 CREB1 CCL2 MYH7 MTOR COL1A1 CTGF SIRT3 IFNG IL18 LTBP2 IL17A IL2 MAPK1 ACE2 NPHS2 BAX NPPA HAVCR1 SYNPO NPPB LCN2 IL6 TNF CASP3 TIMP1 PIK3CA BCL2 TGFB1 PMC8688647__F1 Network map of Elabela signaling pathway in physiological and pathological conditions ACTA2 TBXT AKT1S1 CYBB MTOR COL1A1 FST NLRP3 RPS6KB1 IL18 CCND1 PIK3CA NCF1 TGFB1 GDF3 NCF2 PMC8688647__F4 Network map of Elabela signaling pathway in physiological and pathological conditions CRH FOS AVP BCL2 IL6 TNF MTOR IL1B BAX PMC6744284__F7 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the glomeruli CD14 FOS MTOR GAST IFNG PMC8688647__F3 Network map of Elabela signaling pathway in physiological and pathological conditions ATG12 HAVCR1 MAPK3 PARP1 IL6 CCL2 TNF MTOR EIF4EBP1 CHEK1 DKFZp686F0183 CASP3 RPS6KB1 MAP1LC3B2 MAPK1 ATR H2AX TGFB1 PMC6744284__F6 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the tubulointerstitium BAD FOS TNFSF10 KCTD12 SERPING1 FITM2 MTOR GAST JUN TLR3 IFNG PMC6149884__F1 VAV1 signaling in lymphocytes VAV1 NOTCH1 PHC1 RHO PMC8079762__F1 Targeting Solid Tumors With BTK Inhibitors BTK BAD MDM2 PMC4281466__F1 TGF-beta signaling pathways SMAD4 RHO STRAP PMC6397804__F2 Poly(I:C)-toll-like receptor 3 signaling pathway and polarization of mesenchymal stem cells TLR4 MSC IRF3 TLR3 PMC11510049__F9 Comparative analysis of transcript and protein abundance in the HSP60-HSP70-TLR2/4 signaling pathway in children with severe malarial anemia CD14 TLR4 TRAF6 CD40 CD83 IRAK4 CD80 MYD88 MAP3K7IP1 CD69 TAB3 MAL PMC9178347__F2 Critical metabolic pathways and SAD/FADs, WRI1s, and DGATs cooperate for high-oleic acid oil production in developing oil tea (Camellia oleifera) seeds XK STS HEL-S-162eP PMC3926427__F1 FGF/FGFR signaling pathway EGF GRB2 MTOR PMC3376383__F2 Growth Control by Committee – Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling PATJ AMOT PALS1 CRB3 PMC7880612__F1 Molecular tracing of prostate cancer lethality MYB ASCL1 PTOV1 LGALS8 CD44 SMAD4 PTEN WT1 SOX9 SOX4 TFF1 opn CCND1 EZH2 PMC6443331__F5 AMPK-dependent anticancer activities of honokiol in ovarian cancer cells TSC2 TSC1 MMP9 MTOR PMC9437103__F3 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics CITED4 ULK1 ULK2 MTOR GATA4 PMC4106164__F1 PD-L1 expression and tumor-infiltrating lymphocytes CCR4 IFNGR2 PTEN CCL22 IFNGR1 FOXP3 PMC5609723__F2 Aryl hydrocarbon receptor-mediated hepatotoxicity is a cumulative response to the overall burden of multiple disrupted pathways rather than a single adverse effect FGF21 AHR HEL-S-30 PMC9437103__F2 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics IGF1R IGF1 PTEN PMC8236548__F1 Other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities PALB2 ATM CDK2 BRCA2 RAD50 ATR MRE11A PMC9315891__F3 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues XK XDH RPE PMC9315891__F2 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues XDH LPA HEL-S-5 PMC7710690__F2 PD-1 and PD-L1 interactions and mechanism of T cell inhibition PLCG1 APC LCK ZAP70 IL2 CD80 PTEN MTOR BATF PMC3338748__F1 High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism UBE3A PDK2 HOMER1 SHANK3 SHANK2 PTEN EIF4E MTOR HRAS SYNGAP1 RHEB TSC2 NF1 TSC1 ARC RAF1 PMC8229352__F1 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment ULK1 ATG12 ATG3 WIPI1 MTOR DKFZp686F0183 GABARAP PMC8229352__F5 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment FOXO3A YAP1 WNT1 EGFR CD44 NOTCH1 SRC IL6 MTOR STAT3 PMC8001024__F1 Cohesin cycle in human cells ESCO1 PLK1 SCT WAPAL ESCO2 CDC2 PMC5855797__F6 Signal transduction in relation to the IR GHSR PDK2 PTEN IRS1 PMC2948497__F6 cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells CCNA2 TOP2A DDIT3 DDIT4 AURKB TK1 POLE2 CDC20 POLE CDKN1A CDKN2B CDC6 CDK2 E2F2 CCNB2 CCNB1 TYMS CDC2 CCNE2 PMC5855797__F2 GPCR agonism bias towards insulin receptor activation EBP MMP9 IRS1 NMBR PMC8561165__F1 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease VIT KYNU KMO CXCL9 PMC8561165__F3 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease IL18 KMO CXCL9 PMC9486121__F3 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities GSK3B LRP5 LRP6 PMC9486121__F2 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities PTEN MTOR PMC8126045__F1 Lytic Viral Replication and Co-Infections in the Oncogenesis and Immune Control of the Epstein–Barr Virus PLCG1 ITK MAGT1 CD27 TNLG8A CD48 PMC7199655__F1 Coupled-clock pacemaker system of the sinoatrial node HEL-S-11 PMC10571979__F8 Norrin signals through DVL1 to stimulate barrier properties TSPAN12 LRP5 LRP6 CLDN5 FZD4 DVL1 PMC9659209__F1 Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target? CD44 HDAC2 MORC2 HDAC1 TF CITED2 PMC8243427__F2 MicroRNAs: emerging driver of cancer perineural invasion AGO2 DGCR8 DROSHA RAN PMC8576699__F6 Synergistic effect of chidamide and venetoclax on apoptosis in acute myeloid leukemia cells and its mechanism SOCS3 CDK2 HDAC1 STAT3 BAX PMC4046179__F5 98 proteins that showed significant changes in oxidation levels with HFHS diet were subjected to IPA SDHC SI UQCRH CYC1 COX6B1 SDHA SDHB PMC6008255__F1 Different Wnt signaling pathways DAAM1 APC GSK3B TEF LRP5 PTK7 LRP6 RHO RAC1 PMC3271860__F7 THE ROLE OF IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS IGF1R IGF1 PMC3877826__F9 Model of Interaction with the b-Dependent Developmental Control Pathway.(A) Filamentous growth is triggered by bE/bW-dependent induction of rbf1 expression CLP1 PRF1 PMC2654411__F6 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Mouse Liver EGFR POSTN PRKAR1A DBF4 ORC2 GNG4 TFPI2 IL18 AGA RRM1 NGFR CNTFR SYN1 SP1 NFYB IL1B IRF2 SCARB1 HEL-S-25 SHOC2 MCM7 UHRF1 MCM6 CD27 SMC2 SMC4 PMC7432002__F3 Interaction among MyD88, Toll-like receptor 4, IL-1 receptor signalling pathway in the innate immune response to tick-borne pathogens that could positively control the IFNG secretion; meanwhile, there is lack of IL-18 and IL-12 due to MAS IL1A IL18 TLR4 IRAK2 IRAK4 MYD88 IL12A STAT5B SOCS1 IFNG PMC10982647__F8 Metabolic rewiring mechanisms in drug-resistant breast cancer cells PRMT1 PHGDH FASN PMC8328898__F2 Membrane-Associated Mucins of the Human Ocular Surface in Health and Disease IRAK1 TRAF6 MYD88 PMC7432002__F5 Interaction between IL-1B and I-kB kinase/NF-kB signalling pathway, which have positive activation of Nuclear Factor Kappa B Subunit 1 IKBKB IL18 NFKB1 TNFSF10 IL17A JAK3 JAK1 TNFRSF10A CASP8 IL1B FADD IL12RB1 PMC8824439__F1 CCM in Mtb MCC CIT MAL PMC2654411__F3 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Liver CYP3A4 RXRA PMC3271860__F3 IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS ARHH MLPH APLN ALB LXN RB1 SLPI UBB MYH1 HEL23 FRY ITK VAV3 FYN LIN7A ZEB2 HGS HTT CTSL PLG HEL-S-28 LRP6 HRAS PTX3 ARHG E2F7 IGF1 CASK STX2 DHX34 RAB30 PRNP FST IL18 PKP2 CFH PKIA PEG10 DIPLA1 CPVL KRT1 PPIC TPRN SKIL NTS RRAS PDK4 RPH3A PS1TP5BP1 CTSG GIG8 LYN SOX6 MEP1A CD24 PMC7432002__F4 Interaction between MyD88 and JAK-STAT pathway, linked to IFNA; this interaction is mediated by suppressors of cytokine signalling 3, SOCS family proteins which are part of a classical negative feedback system regulating cytokine signal transduction IFNA21 IFNA1 SOCS3 IRAK2 IRAK4 MYD88 IFNA7 IFNA6 IFNA8 IFNA16 IFNA10 IFNA2 JAK3 IFNA17 PMC8888851__F1 Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity TH NOTCH4 GDF15 ACE2 IFNG PMC7277837__F13 Hypothesized pathway for the production of prokaryotic glycolipids in C PC LPA GAL PMC7664215__F2 Bioactivities and possible mechanisms of pterostilbene MMP2 MMP9 SRC RAC1 MTOR IL1B STAT3 PMC8450498__F1 Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications UGCGL2 GGH NEU1 PLEKHF2 EDEM3 TM2D3 PLD3 SDF2 PUSL1 SIL1 FBXL12 PLOD2 CHPF2 PLAT IL17RA COL6A1 CHPF NPC2 ADAM9 HS6ST2 PMPCB NPTX1 ITGB1 HYOU1 POGLUT2 INHBE PMC8752802__F6 IFNG signaling integrity in colorectal cancer immunity and immunotherapy STAT1 CXCL10 CXCL9 JAK1 EZH2 IFNGR1 PMC8752802__F3 IFNG signaling integrity in colorectal cancer immunity and immunotherapy IFNGR1 AP3D1 IFNG PMC9234286__F2 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis ROCK1 ARHA PMC9234286__F1 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis FGF21 ARHA PMC8752802__F1 IFNG signaling integrity in colorectal cancer immunity and immunotherapy CXCL10 CXCL9 IFNGR2 JAK1 IFNGR1 IFNG PMC7158223__F1 Post-transcriptional mechanisms influence proteome content LARP1 MTOR PMC7709131__F3 Complement functions in the context of cancer FH CR2 PTX3 WWOX PMC7709131__F1 Complement system schematic summary CD59 C4B_2 CD46 MASP1 VTN FH CD55 PMC12071759__F1 TAM metabolization pathway UGT1A4 CYP2C9 CYP1B1 CYP2C19 CYP3A4 UGT1A10 CYP1A1 UGT1A8 CYP1A2 CYP2E1 PMC7158223__F2 Post-transcriptional regulation of stem cell identity under conditions of stress ELF2 ATF4 HSF1 XBP1 PMC9491571__F2 Over- and under-expressed genes are highlighted in WNT signaling pathway BAMBI ROCK2 NLK INVS STOM APC NOTUM CER1 SMAD4 SKP1 PMC2533280__F1 Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood MESP1 HOXB1 CER1 FOXA2 PMC6741067__F14 The signaling cascade activated by the CaSR that induces the arrival of ZO-2 to TJs CASR PC WNK4 PMC3174204__F6 Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs BAD HEL111 ATM TP63 PTEN ATR PMC2242750__F1 Schematic representation of GADS-related signaling in T cells PLCG1 ITK GAB2 LAT PMC4185231__F6 TLR2-dependent activation of Beta-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation GSK3B ALDH1A2 FOXP3 PMC9024760__F1 Cell Culture Media, Unlike the Presence of Insulin, Affect Alpha-Synuclein Aggregation in Dopaminergic Neurons GRB2 PTEN MTOR PMC11279058__F2 Mycoplasma hyopneumoniae generates immune evasion by modulating the host immune system TLR4 TNF XBP1 IL1B BAX PMC3423339__F7 BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II RBPJ ID1 ID3 PMC3935825__F1 Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography NAMPT NRK PMC4580256__F1 PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma PTEN MTOR PMC9317725__F1 Microbial Poly-Gamma-Glutamic Acid (Gamma-PGA) as an Effective Tooth Enamel Protectant HEL-S-62p C6 PMC7070543__F9 Schematic presentation of erinacine A prevention against MPP+-induced neurotoxicity via either induction of the p-PAK1/cdc42/PI3K/AKT/LIMK2 cell survival pathways or the reduction of the IRE1A/TRAF2/ASK1/GADD45/p21 cell death pathway LIMK2 PAK1 TRAF2 CDC42 PMC8529123__F3 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA SPARC FOXK1 PTEN EIF4E SLC39A10 PMC6064744__F2 Schematic representation of cellular mechanisms possibly implicated in miRNA dysregulation in prion diseases ADAR APOBEC1 DROSHA TF PMC8529123__F2 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA FOXF2 FOXA1 ARPP19 SENP1 CENPF CDK4 PMC5529928__F1 CXCL12/CXCR4 signaling and related pathways in HCC progression SMAD2 CXCR4 CXCL12 PMC6099188__F1 Bile acids are synthesized in the liver from cholesterol by two metabolic pathways known as the neutral (or classical) and the acidic (alternative) pathways CYP27A1 GCA CYP8B1 CYP7B1 BAAT CYP7A1 PMC7052306__F1 Activity-dependent synaptic plasticity at the Drosophila larval NMJ PMC4790094__F2 Divalent cation signaling in immune cells MAGT1 BCR LCK TRPM7 STAT3 PMC4879098__F1 Lysosomal–autophagy pathway M6PR CAD BAX PMC5336271__F4 Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology SNAI1 MYC FBN1 PTEN EIF3E HOXA13 MAPK1 SMO PRRX1 IRF7 BMP2 MYOCD VEGFA NRG1 TNF TSPYL5 CNTF ANGPT1 ORMDL3 ERBB2 IGFBP4 STK11 MAP3K14 MAP3K8 SPHK1 FLT3 OSM SOCS1 BRD4 STAT3 PMC5520491__F1 Classical and new Wnt/Beta-catenin pathway canonical and non-canonical pathways APC RYK RHO SKI JUN PMC7792426__F7 Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment IGF1 SMAD2 CCL20 IGFBP6 IGFBP5 PMC4999106__F2 Main components of innate immune system in epidermis and their role in atopic dermatitis (AD) PDC NOD1 NLRP1 PMC4907392__F5 Network computed by Xtalk for crosstalk from the Hippo signaling pathway (A) to the TGFB signaling pathway (B) YAP1 SMAD2 SMAD4 WWTR1 PMC7876357__F5 Hyaluronan, Transforming Growth Factor B, and Extra Domain A-Fibronectin: A Fibrotic Triad BAMBI TLR4 ATM USF2 SMAD2 EGFR SMAD4 SRC RHO MYD88 PMC4907392__F4 Paths used to facilitate literature validation FOS PRLR MAPK3 GSK3B MAPK1 SP1 HIF1A JUN PMC7957049__F2 Wnt signaling pathway activation and inhibition APC GSK3B PMC3701138__F1 Main branches ofWnt signalling pathways in neuronal development LRP5 LRP6 RYK ROR2 RHO CDH2 PMC4907392__F6 Crosstalk network constructed by Xtalk from the NFKB Pathway (A) to the Neurotrophin Pathway (B) using the KEGG-family network MAPK8 FOS JUN PMC6166714__F7 IRAK4 and MyD88-dependent TLR signaling IRAK1 TRAF6 IRAK4 MYD88 TAB3 PMC3425527__F1 Hedgehog signalling SUFU PTCH1 SMO PMC7851346__F8 URA-mediated EAE Mitigation by Directly Targeting Aryl Hydrocarbon Receptor AHR CSF2 PMC5015539__F2 Restoring immune tolerance in neuromyelitis optica PREB CD44 CD19 CD24 PMC8038143__F5 Link between chemoresistance and MMP-7 shedding of Fas ligand ATM ATR FADD BAX PMC8369429__F2 Peptides that immunoactivate the tumor microenvironment BTLA CD80 TIGIT LAG3 HEL-S-66p PMC7763502__F1 Effect of Brassicaceae bioactives compounds upon the transcription of genes related with inflammation TLR4 KEAP1 SFN PMC5393410__F3 Cancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification PIK3CD IL21R SOCS2 FGF8 STAT5B PDPK1 OSMR STAT1 ITK MMP7 FLT1 FYN KDR FGF10 CNTFR IL7R IL9R CSF2 PREX1 PRKCI FOS PLA2G6 MAPK7 TCF7L2 FZD4 FGF12 IFNAR1 IL23R IL10RB IL2RG NR1C2 SHC4 PLA2G2D IL2RA PLA2G4F IL11RA FGF14 LAT RPS6KA6 HGF EGFR CSF3R INS PLA2G2C CCND3 CCND2 FGF9 INSR PIM1 PLA2G12A ATF4 PDGFA SOCS7 LEPR STAM2 CDK4 FGF22 JUN IL2RB FGF7 PDGFRA FGF2 FGF18 PTPRF PTPRC LEF1 SLC2A4 GAB2 STAT4 PLA2G3 PIK3CA JAK3 TYK2 IL6ST JAK1 VEGFB SHC1 PLA2G10 STAT3 PMC9228816__F2 Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2 MOCS2 APP MBIP SUOX XDH MOCS3 TF PMC8099739__F2 VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections ISG15 RUNX2 CCN3 IFIH1 IFNG PMC10552298__F1 , Hypothetical VOC production pathway originated from lipid peroxidation of membrane lipids HEL-S-133P PMC3507272__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway BRAF GRB2 RAF1 PMC8256158__F7 Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation TLR4 JAK1 SP1 TNF STAT3 PMC3430113__F4 Schematic depicting a central role for transforming growth factor (TGF)B1 signaling in osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis (LCH) PC LPA TGFB1 FASN STAT3 FOXP3 PMC6004768__F1 Defective identified pathways in immunodeficiencies predisposing to high susceptility to Epstein–Barr virus (EBV)-driven B-cell lymphoproliferative diseases ITK MAGT1 CD27 TNLG8A CD48 MICA CORO1A PMC1410746__F3 Genmapp view of the epidermal growth factor (EGF) signaling pathway EGF MAP2 ERBB2 MBP SOST EGFR NRAS GRB2 HRAS PMC4454399__F2 Top Ingenuity Pathway Analysis (IPA) interactome derived from transcriptional regulators found in the Vesiclepedia database RUVBL2 NPM1 YBX1 RUVBL1 CAND1 NACA RCOR2 FUS IRF6 MNDA ALYREF COPS5 BTG1 PURB PMC7876795__F3 Alternative signaling activation induced FGFR-TKI resistance FRS2 ERBB3 EGFR PTEN MTOR EPHB3 PMC6480527__F10 Model of the Nrf2-mediated oxidative stress response pathway in bovine granulosa cells under moderate oxidative stress conditions and under antioxidant (quercetin) supplementation MAF KEAP1 NQO1 PMC4937204__F1 cGMP-PKG signalling in the cardiomyocyte RGS4 SMAD2 PGC TRPC6 RGS2 GATA4 PMC5893408__F1 Sphingosine-1-phosphate receptors and innate immunity S1PR2 S1PR1 S1PR3 S1PR5 RHO PTEN S1PR4 PMC9204905__F6 Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer CYP2B6 UGT1A3 SULT2A1 SULT1E1 HSD17B1 HSD17B7 CYP1A2 CYP2E1 UGT2B11 SULT1B1 SULT1A1 UGT1A4 CYP2C9 CYP2C19 CYP3A4 ST1A5 STS UGT1A10 CYP1A1 HSD17B3 UGT2A1 UGT1A1 CYP3A7 PMC11010261__F1 YAP/TAZ‐TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma TEAD3 NF2 HEL-S-28 SRC TEAD4 LATS1 RHO MOB1A MOBKL1A LATS2 DLG5 TEAD2 PMC6117460__F1 A Retinoic Acid Signaling Pathway to Promote ProliferationRetinoic acid, acting via HIF1A and VEGF, is necessary for S-phase re-entry of NSPCs VEGFA CDK4 HIF1A CDK6 PMC11544849__F4 Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research EGF PMC8485144__F3 Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility FOXP4 SMOC2 AHRR TRIM2 PRKG1 AURKA GATA4 DNAH2 ZNF239 CACNA1H CCDC60 SYNE1 PARK2 FRS2 LTBP2 TEF RGMA SOX6 CHFR COL4A2 RALGPS2 TERT PMC3999155__F6 HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1 TBK1 TRAF3 IRF3 MAVS PMC2670022__F1 Pharmacological targeting of the serotonergic system for the treatment of obesity POMC NPY AgRP MC4R ARC PMC2966096__F7 A hypothetical model of PAR-1 and PAR-2 activation by coagulation proteases when either EPCR or an unknown FX/FXa receptor is occupied by natural ligands TH PC APC ARHA RAC1 PMC7031348__F2 Inflammation and muscle protein turnover IGF1 GSK3B IRS1 STAT3 PMC10381408__F4 Compound K Production: Achievements and Perspectives PGM2 IPP PMC10381408__F3 Compound K Production: Achievements and Perspectives CMC1 F2 RB1 ARAF PMC8856628__F1 Mechanism of action of GEM in PDAC treatment CDA RRM1 DCTD PMC2891859__F1 General overview of BDNF and GDNF signaling mechanisms RET FYN GDNF BCL2 RHO BDNF PMC7016420__F3 Metabolic reprogramming of HSC GOT2 GPT2 TES MAL PMC6511648__F1 LSD1–NOTCH–ASCL1 Axis in Small Cell Lung Cancer (SCLC) ASCL1 NOTCH1 REST HES1 PMC5818364__F2 Acyl-DHAP pathway of ether lipid synthesis GNPAT FAR1 LPA HEL-S-5 PMC3632562__F4 PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects PAK1 LIMK1 RAC1 CDC42 PMC1782125__F2 Signal transduction of TNFRI LTA TRADD RELA TNF TRAF2 FADD LTBR PMC4779661__F3 Relationship between cellular fatty acid (FA) metabolic pathways and observed associations of FAs and enzyme acitivity estimates (EAEs) with colorectal adenomas SCD ELOVL6 PMC3230512__F1 Model showing the various molecular components associated with the store-operated calcium entry pathway TRPC1 ORAI1 STIM1 PMC6136097__F1 Current putative prognostic biomarkers in glioblastoma HEL-S-26 PTEN PMC8074247__F10 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer LOXL2 FECH HGF IGF1 NGF ATM CXCR4 HEL-S-87p ATR TERT PMC8892134__F1 Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer ABL2 IGF1R IGF2 PTEN LATS1 RHO LATS2 RHEB INSR TSC2 TSC1 IGF1 GRB2 AXL STAT3 PMC11641605__F6 Crosstalk of ECM and hypoxia in the Hippo signaling pathway EGR1 PATJ ERBB4 AMOT TBX5 AJUBA LATS1 RHO LATS2 FRMD6 PMC11641605__F5 Hypoxia regulates intracellular signaling through multiple mechanisms EPO LATS1 RHO PMC3529674__F5 MyD88-independent TLR signaling TBK1 TLR4 IRF3 PMC11641605__F3 Intracellular signaling regulation of the ECM signal transmission LATS1 LATS2 VAV2 PMC5484492__F5 Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy FLT4 Nbla10317 MYC PBX1 HRAS PARVA FOXO1 INSR LIMS1 RS1 RICTOR RET LAMB1 FCER1A FOXA1 PTPN1 SYK MS4A2 STAT3 PMC5484492__F4 microRNAs in cancer ATM APC MYC CD44 NPL PTEN SOX4 PMC9583386__F1 Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer NLRP3 NGF CD163 CD80 ARG1 PMC8882121__F6 Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades HEL70 TUBB6 MAPK14 IGFBP7 RALA ARHA PTEN PROX1 HEL-S-87p TXN RPTOR ARHG PLD2 ARPC2 CDK2 ANXA2 CLTC RAF1 VCP EPHA2 ACTN4 TGFB1 PMC4331664__F5 The metabolic pathways of Mtb that interconnect glycogen, Tre and other carbohydrates MAL PMC2802426__F1 Molecular mechanisms that regulate ionotropic glutamate receptor distribution during hippocampal mGluR-LTD induction and expression MAP1B ARC PSD PMC7040165__F2 Controlling pluripotency using small molecule inhibitors and growth factors SOX2 LIF LEFTY2 FGF2 KLF4 SOX17 BMP4 PMC7040165__F1 Extrinsic signaling pathways governing stemness of pluripotent stem cells NODAL LIF PMC2802426__F2 Schematic model of molecular mechanisms underlying regulation of gene transcription and protein translation during mGluR-LTD in postsynaptic neurons of hippocampal CA3-CA1 synapses EEF2K EGF MAP1B EEF2 GRB2 CCND1 SRC ARC CDK4 MTOR PSD PMC7916426__F1 BA synthesis and transport pathway PC ATP8B1 FGF19 FGFR4 CYP7A1 PMC8430485__F2 Immune-Checkpoint Inhibitors for Metastatic Colorectal Cancer: A Systematic Review of Clinical Outcomes EGF EGFR VEGFA CD80 MTOR PMC8647629__F1 The Renin–Angiotensin System in the Cancer Stem Cell Niche COX2 ATR PMC2688381__F4 Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia FADS2 EBP ACACA ACSS2 STARD4 PMC8500019__F3 Endothelial activation, dysfunction and immunothrombosis in COVID-19 TFPI ACE2 TF PMC10942463__F10 Nucleotide metabolism associated with purine and pyrimidine pathways RRM1 IMPDH1 NDP PMC5410568__F1 The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases ATF4 EIF2A TRAF2 BAX PMC4414306__F5 IGFs/PI3K/Akt signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) TSC2 PDE3B BAD TSC1 VAMP2 IGF1 IGF2 PTEN EIF4E MTOR PMC12106402__F1 Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities DHTKD1 AASDH AADAT AASS GCDH PMC4414306__F4 Growth hormone signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) STAT1 A2M IGF2 CEBPA IRS1 STAT3 PMC4418918__F6 Translational effects of Stat1 STAT1 EIF4E PMC3402097__F4 Lineage-specific and ubiquitous biological roles of the mammalian transcription factor LSF CDK2 CDK4 CDK6 PMC8332857__F5 ZNF217: the cerberus who fails to guard the gateway to lethal malignancy BAD ZNF217 ERG ERBB3 MDM2 BAX PMC2667897__F1 TGFB superfamily signaling: notes from the desert EGF NUP214 GRB2 SRC SKI SMURF1 PMC10647460__F7 Regulatory mechanism of cis-9, trans-11 CLA on milk fat synthesis HMOX1 PPARG DKFZp686F0183 PMC8611103__F3 Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease RHO PMC7952440__F1 miRNAs flowing up and down to facilitate keratinocyte hyperproliferation USP2 TIMP3 PTEN IL1B PMC3836193__F1 Role of apoptosis in colon cancer biology, therapy, and prevention BAX PMC5755720__F1 ERBB signaling in CTCs of ovarian cancer and glioblastoma EGF ERBB4 ERBB2 ERBB3 MYC GRB2 PTEN MTOR JUN STAT3 PMC12056003__F7 IFITMs on CHIKV infection in human dermal cells STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 PMC4586487__F6 PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells PTBP1 SFRS3 PMC7226765__F9 Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum ELF2 ATF4 XBP1 PMC5409837__F8 High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells IGF1 PDGFRA INSR PMC4177985__F1 LD-Aminopterin in the Canine Homologue of Human Atopic Dermatitis: A Randomized, Controlled Trial Reveals Dosing Factors Affecting Optimal Therapy DHFR TYMS PMC8455910__F10 Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway NLRP3 DPP4 CTCF PMC3075605__F2 NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28 USP21 TRADD IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR4 BCL10 CYLD LCK TRAF2 TAB3 PMC12056003__F4 Genes modulated by the expression of IFITM1, 2, and 3 in HFF-1 cells TBK1 TANK IFNA1 TLR9 TRADD IRAK1 TRAF3 TRAF6 MYD88 MX1 IFNLR1 STAT1 TLR8 TLR7 BCL10 CYLD IFNA2 STAT2 IRF7 IRF9 MAP3K7 DDX3X IRF3 IFNAR2 TNF NCAM1 IFNAR1 TRIM25 MAP3K7IP1 TLR3 CARD9 MAP2K1 TYK2 JAK1 IFIH1 TBKBP1 MAVS PMC4128340__F3 Canonical non-Smad pathway tumor growth factor (TGF)B signaling PML THBD FLNA EFNB2 ACTN1 IFITM2 EMP3 SMAD4 ITGA7 FCGR2C NRP2 OSMR HRH1 PDLIM4 PI3 PELO SLC67A1 OSBPL3 TPP1 ECE1 EMP1 MVP SGSH PLAUR RUNX1 STEAP3 HOMER3 LIF EHD2 PDPN CEBPA TAGLN TNC MMP14 CD151 ZYX NRP1 GRB2 PLA2G5 CA12 COL4A2 STAT3 PMC7306774__F7 Proposed mechanism for CRY’s effect on susceptibility to stress-induced depression-like behavior FOS PER2 PMC4414306__F7 NRF2-mediated oxidative stress response MAF AOX1 OSTN KEAP1 PSAT1 PKIA GHR PPIB RYR3 EN1 TXN MSMO1 PMC7161485__F1 ADE and antibody mediated immunopathology. Left panel: For ADE, immune complex internalization is mediated by the engagement of activating Fc receptors on the cell surface STAT1 HEL-S-62p C4B_2 PMC5932566__F2 Molecular and signaling impact of MUC5AC in various malignancies MMP3 MMP7 MUC5AC VEGFA CXCL8 CDH2 PMC7122041__F9 Coagulation profile of endothelial surface during normal (left panel) and activated state (right panel) PC TFPI PLG APC TF PMC4422082__F4 CD44- and CD44v-induced RTK for apoptosis resistance COX2 HGF ERBB2 GRB2 SRC CDC37 VAV2 PMC7426366__F3 Action of ceramide on insulin signaling and glucose metabolism in muscle cells FGF21 LASS1 IRS1 PMC10382901__F5 Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling GLI3 POR GLS PMC10912719__F2 DNPNB pathway ADSL FH PURA PAICS PURB HEL-S-70p GLA PMC9001080__F3 Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals KEAP1 GCLC RBX1 PMC8523568__F3 Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway SPTLC1 VAPB CASR GANAB MCU CANX VAPA STUB1 HEL-S-269 CLTC RAB5C TMCO1 UGGT1 PMC3923981__F7 Cytosolic Functions of MORC2 in Lipogenesis and Adipogenesis MORC2 ACLY PMC7426366__F1 Metabolism of sphingolipids CERK SMS KDSR PMC10912719__F7 Regulation of DNPNB enzyme clustering and purinosome assembly-disassembly under the control of regulatory proteins and signaling pathways ADSL PAICS HEL-S-70p PMC3989821__F2 Prostate smooth muscle contraction and assumed connections to the regulation of prostate growth RHO PMC11016731__F3 Rationale for immune checkpoint inhibitors plus targeted therapy for advanced renal cell carcinoma APC MSC ZAP70 VHL MTOR PMC11016731__F2 Mechanism of tumor cell genesis induced by hypoxia inducible factor (HIF) EPO VHL MTOR PMC6513836__F7 Brief summary of the possible mechanisms of KSHV-mediated pathogenesis at the cellular level IL10 IL18 NOTCH1 IL6 SMAD1 CDK6 HES1 PMC4023701__F5 Crosstalk pathway SPARC FGFR4 CCL2 SLIT3 SLIT2 COL1A1 PLA1A CLU CD81 ISG15 PCSK9 IGDCC4 CFH opn SERPING1 ROR2 MYOC CALD1 SELE FGF7 ITGA1 RELN CFB PF4 LIF VEGFA LAMA4 SDC2 SDC3 CTSG TNC RECK MME PMC9476726__F11 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer DLL4 DLL3 PMC3241422__F8 Mpk1-driven FKS2 transcription ROM1 PMC9476726__F10 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer CD14 LTA LBP TRAF6 MYD88 MAP3K7IP1 PMC4534763__F6 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer E2F4 PLK1 CDC6 CDK2 SMAD2 SMAD4 ORC3 RAD21 CDK7 PCNA SKP2 PMC5915111__F10 Signaling pathways in the glaucomatous trabecular meshwork BAMBI TLR4 SMAD4 SMAD1 PMC4534763__F4 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer NRG3 BAD BTC GRB2 NRG2 SHE HBEGF MTOR NRG4 JUN CBL PMC6163961__F4 Apoptosis inhibition in cancer BAD TGFBR1 TGFBR2 BAX PMC3856408__F1 Endogenous small RNA pathways involved in host defense and viral pathogenesis in plants and animals AGO1 AGO2 DGCR8 AGO4 DROSHA PMC6163961__F1 Apoptosis extrinsic and intrinsic (mitochondrial) pathways BAD PPA2 CAD DCC FADD BAX PMC6163961__F2 Apoptosis intrinsic (endoplasmic reticulum (ER)) pathway ATF4 EIF2A TRAF2 XBP1 BAX PMC4613518__F1 Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention MAF GCLM KEAP1 AKR1C1 RBX1 HMOX1 PMC6389897__F2 Folate metabolism is linked to the homocysteine metabolic pathway HEL-S-61p VIT PMC5138253__F5 Different roles of Gq- and Gs-coupled GPCRs expressed by AgRP neurons in food intake NPY AgRP CA11 PMC12009754__F8 Graphical abstract of the study APC FKBP5 PMC8767067__F4 Aberrant Expression of miR-1301 in Human Cancer RUNX1 SOX2 GSK3B VEGFA CD44 DKFZp686F0183 RHEB EIF5 MMP2 CDK2 KLF4 SFRP1 EZH2 AXIN2 CDH2 UBE4B BCL9 PCNA MYLK STAT3 BAX PMC2728081__F2 Regulation of B-cell entry into the cell cycle PI3 BCR LYN SYK PMC6224214__F8 Liver X Receptor (LXR) pathway as the result of the integration between transcriptomic and metabolomic data APOA4 HMGCR PMC2981059__F6 HER/HER2-PI3K-Akt-NFKB-elicited pathway in prostate cancer cells EGF RELA PTEN PMC8948514__F1 Case series of cerebral venous thrombosis as the first manifestation of homocystinuria HEL-S-61p PMC8626127__F8 Ovalbumin antigen-specific activation of human T cell receptor closely resembles soluble antibody stimulation as revealed by BOOST phosphotyrosine proteomics PLCG1 CD3D FOS NCK1 PTPRC ITK MAPK12 LCK ZAP70 GRB2 CD3G LAT CD3E PMC6838365__F40 Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3B/Beta-catenin signaling pathway MYH9 MAP2K4 GSK3B TRAF6 PMC11906485__F1 Biosynthetic pathway of plasmalogens and RCDP types based on gene mutation PEX7 FAR1 PEX5 PMC6111868__F7 Signalling pathway by which kallistatin inhibits endothelial senescence, oxidative stress and inflammation VCAM1 HEL-S-44 SIRT1 PMC6105545__F6 Persistent EcoHIV infection induces nigral degeneration IL10 TLR4 IL9 NFKB1 CCR7 SRC CCL2 IL5 IFNG HEL-S-162eP PMC7811275__F3 Regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) CASP6 IRF9 RIPK3 IRF3 IFNAR2 IFNAR1 ZBP1 GSDMD CASP3 NLRP3 RIPK1 IRF-1 CASP8 FADD MLKL MAVS PMC2782690__F3 Is cancer a disease of abnormal cellular metabolism? TIGAR F2 MYC CIT PMC5938286__F2 PD-1/PD-Ls signaling pathway APC ZAP70 MTOR PMC5940272__F1 Alternative pathways of type I IFN induction during M TBK1 CGAS TLR4 IRF3 NOD2 PMC5938286__F1 Illustration of cross-communication network of BCR, PI3K, apoptosis, and NFKB signaling pathways CDA TRADD RELB MYC PTEN MYD88 TNF MTOR BCL6 BTK CARD11 BCL10 BCR RELA MDM2 BCL2 CD40 SYK FADD BAX PMC3256223__F1 Modeling of miRNA and Drug Action in the EGFR Signaling Pathway EGF BAD EGFR PMC4389797__F7 Schematic showing the TGFB/LIF- mediated tumor suppressive role in melanoma SMAD2 LIF SMAD4 STAT3 BAX PMC5938286__F3 Illustration of JAK/STAT signaling pathway MYC SRC BCL2 MTOR PMC3742001__F7 Schematic diagram summarizing the signaling pathways relevant to this study TSC2 TSC1 GRB2 PMC8928136__F4 Signaling pathways by DJ-1: An updated overview TRAF6 TRAF2 PMC8928136__F3 Signaling pathways by DJ-1: An updated overview RNF5 PTEN FIS1 PMC8928136__F5 Signaling pathways by DJ-1: An updated overview CASP6 SIRT1 BAX PMC5515553__F1 Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells LIF PRLR JAK1 PRL STAT3 PMC8928136__F2 Signaling pathways by DJ-1: An updated overview DDC HEL-S-44 BMF PMC6514318__F1 Molecular genetic pathways in long-term epilepsy-associated tumors (LEATs) and pediatric type diffuse low-grade glioma (DLGG) ULK1 BRAF PTEN ATG101 EIF4E DEPTOR IRS1 RHEB TSC2 NF1 TSC1 FGFR1 EIF4B SGK1 PMC3700727__F1 The Aryl Hydrocarbon Receptor: A Novel Target for Immunomodulation in Organ Transplantation AHR CYP1B1 CYP1A1 TF PMC7494983__F5 Epigenetic modification and therapeutic targets of diabetes mellitus EBP TNF IRS1 PMC5760518__F5 Signaling pathway activated by piperonylic acid EGR1 EGFR STAT3 PMC8884172__F10 Downregulation of Three Immune-Specific Core Genes and the Regulatory Pathways in Children and Adult Friedreich's Ataxia: A Comprehensive Analysis Based on Microarray PMC9262990__F14 Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer WAS TNF MTOR IRS1 PMC7594527__F1 Lipid metabolic pathway in S PDC PC SI LPA PMC9168369__F1 Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies IDO1 HEL-S-90n GIG8 KYNU KMO IDO2 PMC3489783__F3 Representative KEGG pathway change of Endocytosis VPS25 F2 EHD2 EGFR LDLR CHMP3 KIN ARF6 VPS36 PMC12150572__F8 Role of CIP2A in OA cartilage KY CEMIP CIP2A REL PMC3766957__F2 Cancer metabolism: fatty acid oxidation in the limelight ME1 HEL-S-26 PC CPT1C UCP3 UCP2 FASN BAX PMC8156589__F1 Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road RAC1 TET2 PMC8532171__F6 Flg22- and D-glucose-biased signaling FLOT1 CLC BAK1 PMC6480114__F1 Proposed mechanical cues regulates Hippo signaling pathway in gastric tumorigenesis ARHGAP20 AMOT YAP1 GC MYC SRC LATS1 RHO ARHGAP29 LATS2 PMC2647614__F2 Novel Insights into Lung Transplant Rejection by Microarray Analysis SET VTN LCK IL2 IL2RA THBS1 IL4 IL5 IL2RB PMC9489610__F5 Necroptotic signaling mechanisms and outcomes in ALS TBK1 RIPK1 RIPK3 HEL-S-44 OPTN CASP8 FADD MLKL PMC3576254__F5 Pathway analysis NF1 LEP PC DAO MAX FLNA APC REST JUN PMC8064146__F5 Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment CDS1 PC LPCAT3 ENPP7 SGMS1 SCD PISD PMC9489610__F3 Evidence for activation of apoptosis in ALS TBK1 CASP3 RIPK1 BAD MAX CASP9 BCL2 C9orf72 MCL1 FUS BAX BOK PMC186326__F7 Model for Fgf18 regulation of long bone growth IHH FGFR1 FGFR3 SMO FGF18 FGFR2 PMC7139751__F1 Akt signaling pathway TSC2 RICTOR PI3 BAD TSC1 TBC1D7 PTEN MTOR DEPTOR RHEB MLST8 PMC10384200__F4 Association between High Interferon-Gamma Production in Avian Tuberculin-Stimulated Blood from Mycobacterium avium subsp. paratuberculosis-Infected Cattle and Candidate Genes Implicated in Necroptosis HMGB1 USP21 TRAF3 FES RIPK3 IRF3 TNF POR CYLD IL33 H2AX OSM FADD MLKL PYGL PMC3208682__F1 Expression patterns of the TLR signaling pathway in CLL TBK1 CHUK IFNA1 MAP2K4 IRAK1 IRAK2 TICAM2 TRAF6 IRAK4 MYD88 IL12A MAP2K3 RIPK2 TICAM1 IFNG BTK SIGIRR ECSIT JUN CD14 IL10 MAP3K1 FOS MAP3K7 IRF3 TNF MAP3K7IP1 HEL-S-31 IKBKB NFKBIA NFKB1 RELA CD80 TIRAP PMC3094730__F2 Dendritic cell control of tolerogenic responses SOCS3 SOCS1 FOXP3 PMC6676383__F5 Metabolic pathway map showing fold changes of leaf metabolite concentrations of Plantago lanceolata subjected to different precipitation and temperature treatments CIT MAL PMC8862784__F2 ACE2: a key modulator of the renin-angiotensin system and pregnancy TNF ACE2 IL1B NQO1 PMC7104985__F2 Broad depiction of the endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) signaling ATF4 EIF2A TRAF2 PMC7104985__F1 Schematic depiction of production and sensing mechanisms for type I interferons (IFNs) TBK1 CGAS TLR9 STAT2 IRF7 IRF3 MTOR IRS1 TLR3 STAT1 TLR8 TLR7 TLR4 STAT4 TYK2 JAK1 MAVS STAT3 PMC6125320__F7 The molecular mechanisms underlying the role of mTOR/p70S6K/HIF-1A signaling pathway in the regulation of TLR4 inflammatory signaling and TH17 cells in liver IRI TLR4 TRAF6 ATF3 PMC11003953__F3 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic FFAR3 FFAR2 BDNF PMC11003953__F2 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic GDNF PYY BDNF TGFB1 PMC9699542__F4 Mitophagy Induced by Metal Nanoparticles for Cancer Treatment PINK1 HIF1A MTOR PMC3836169__F1 PTEN in cancer, metabolism and aging IGF1 FOXO3A F3 IRS1 FOXO1 MLST8 PMC83901__F8 Model of the regulation of class II MHC genes by IFNG STAT1 MHC2TA JAK1 IFNG PMC9146539__F1 Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease SNCA RAB5A ANXA2 DRD2 PMC10893548__F7 NMN promotes hair growth by regulating the paracrine system of cells IL1B PMC9489610__F1 Immunological outcomes of apoptosis versus programmed necrotic mechanisms XKR8 VTN MERTK ATP11C PMC2013861__F4 Signalling pathways activated by the RXFPs RXFP4 EGFR SRC RXFP3 RXFP2 PMC4889216__F7 Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt ME1 ME2 ME3 PMC6843654__F4 Top three molecular networks identified by Ingenuity Pathway Analysis (IPA): (a) Network 1 SPARC PROS1 CTSS OBSCN MOGAT2 NKTR TTN CRKL TACC2 CHEK2 STRN RNF20 NF2 B4GALT4 NR1A2 SGTB EPYC NCAM2 SPRED1 CTSH HCN4 LAMA1 SETX PTPRE SMAD1 MYLK ESPL1 PMC7983894__F4 Oxidative stress leads to multiple death modalities through various pathways in melanocyte NLRP3 HMGB1 RIPK1 KEAP1 AIFM1 RIPK3 PARP1 TRPM2 MLKL GSDMD SIRT3 PMC7568049__F1 SARS-CoV-2 infection pathway in humans and COVID-19 progression PC ACE2 TG PMC5344271__F3 Upon SV40 infection of mesothelial cells, Tag (Large T) and tag (small t) antigens are expressed IGF1R HGF IGF1 EGFR NOTCH1 PMC6668073__F4 Hedgehog signalling and SMO inhibitors action in MB PTCH2 SUFU PTCH1 GLI3 SMO PMC6327307__F3 Epigenetic control of CD8+ T cell differentiation NUMB PRC1 KLRG1 CDKN2A FBXW7 SIRT1 FOXO1 TF BATF BRD4 PMC6327307__F2 Epigenetic control of CD8+ T cell differentiation GC DNMT3B PMC6222347__F7 Suggested mechanism of action of morusin in MDI-stimulated 3T3-L1 cells and primary adipocytes EPO CEBPA PMC3800035__F7 Heterotrimeric G-Protein, GA16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer WNT3A WNT7A LRP6 ROR2 ROR1 PMC6434253__F2 Sub-pathways identified using the sub-pathway strategy PLCB3 ZNF71 CHUK GNB2 EGFR ERBB3 NRAS MYC MTOR YLPM1 LYN GRB2 JUN SHC1 ZNF76 AKT3 PMC4839264__F7 mTOR signaling in ALK+ ALCL oncogenesis RICTOR ALK EIF4E RPS6 MTOR PMC3070842__F1 Lessons on transcriptional control from the serum response network EGR1 FOS HMGN1 IFNG PMC2860379__F2 Genes affecting dystroglycan glycosylation associated with congenital muscular dystrophy FKRP POMT1 POMT2 PMC2684977__F2 Biologic actions of isoprenoids BMP2 ARHA RAC1 PMC4496162__F3 MicroRNAs in apoptosis, autophagy and necroptosis ELF2 TSC2 BAD TSC1 ATG12 EIF2A PTEN BNIP3 MTOR RHEB MLST8 PMC5388243__F7 Schematic of the proposed mechanism of MIR506 induction of autophagy-related cell death in PDAC cells through the STAT3 signaling pathway BCL2 STAT3 PMC8478810__F2 Wnt pathway: an important control mechanism in bone’s response to mechanical loading LRP4 SOST LRP5 DKK1 PMC8478810__F4 Wnt pathway: an important control mechanism in bone’s response to mechanical loading ZNRF3 RSPO1 RNF43 LRP5 GPR49 LGR6 PMC4496162__F4 MicroRNAs in apoptosis, autophagy and necroptosis TRADD CYLD HEL-S-11 PGAM5 TRAF2 FADD TLR3 MLKL PMC7968933__F2 Mechanisms through which biological sex could affect BBB integrity ROCK2 CCR2 ANXA1 TIMP1 VCAM1 ARHA RHO SP1 PMC5867300__F1 Immune modulatory signaling in antigen-presenting cells (APCs) induced by binding of interleukin-10 (IL-10) to the IL-10 receptor SOCS3 IL13 TYK2 JAK1 IL10RA IL1B GAA STAT3 PMC5659283__F2 PTEN controls the G2-M transition to prevent bypass of the G2 checkpoints and premature entry into mitosis (M) CCNB1 PTEN CDC2 ATR TOP2A CHFR PMC6938687__F2 The RTK-PI3K-AKT-mTOR signaling pathway NPRL2 PI3 C16orf35 IGF1R IGF1 DEPDC5 MYC TBC1D7 DEPTOR RHEB CCND2 AKT3 PMC6752985__F1 PI3-K/Akt signaling pathway TSC2 CDK2 PTEN PMC7168269__F1 Roles of gastric cancer stem cells (GCSCs) in the immune microenvironment SMAD2 CXCL12 STAT3 PMC4127596__F2 Beclin 1, its protein interactions and its role in autophagy HMGB1 PINK1 AMBRA1 TRAF6 UVRAG MAP3K7IP1 VMP1 PMC4127596__F1 Autophagic process and some of its major regulators TSC2 ULK1 TSC1 ATG12 DKFZp686F0183 IRS1 RHEB PMC10302309__F2 Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies BRAF ALK NTRK1 EGFR PTEN RB1 MTOR CDK6 CCND2 CCNE1 RET CCND1 CDK4 ROS1 PMC3742652__F4 Proposed Twist2 involvment in ovarian cancer BAD TWIST2 BCL2 PMC7643212__F4 Tumor necrosis factor receptor-associated factor 1 pathways involved in T cell survival TRAF1 JAK3 FOXO1 PMC8074086__F1 Mycosis Fungoides and Sézary Syndrome: An Integrative Review of the Pathophysiology, Molecular Drivers, and Targeted Therapy PLCG1 CCL21 CCR4 ARHA STAT5B FOXP3 STAT1 CARD11 STAT4 CCR7 CCL19 JAK3 JAK1 GATA3 STAT3 PMC8274420__F4 Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes EGF SMAD2 APC EGFR SMAD4 PTEN HIF1A MTOR TERT PMC3884931__F1 Mammalian target of rapamycin (mTOR) signaling pathway regulation TSC2 EGF NGF RHEB PMC2755790__F1 Network analysis of differentially expressed proteins (red symbols) involved in arteriogenesis HEL32 EFNB2 ARHA NOS2 JUN ABRA PMC8478810__F1 Wnt pathway: an important control mechanism in bone’s response to mechanical loading APC GSK3B LRP5 PMC5309878__F3 Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients PC LPCAT3 LPCAT4 LPA IL1B LPCAT2 LPCAT1 PEMT PMC9304626__F1 Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers GPX4 SLC7A11 HEL-S-64p PMC5006924__F7 IL-10-producing B cells induced by TRAPs MYD88 PMC8138659__F2 Nkx3.1 in Cancers and Stemness SOX2 KLF4 STAT3 PMC9181656__F2 Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance CCR2 NOTCH1 CCL2 STAT3 PMC4142215__F1 Genome wide proteomics of ERBB2 and EGFR and other oncogenic pathways in inflammatory breast cancer EGF ERBB4 BAD BTC SHE MTOR JUN CBL PMC5581331__F2 P53 and pRB pathways during senescence CDK2 MDM2 CCND1 CDK4 CDK6 PMC11956214__F8 Cell cycle signaling and key proteins ME1 CDK2 CYC1 PCNA MAL PMC8301816__F2 Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers EGF IGF1R IGF1 EGFR SRC STAT3 PMC12153268__F7 The mechanism of LAG3 inhibition of IFNG production by NK cells STAT1 PSAT1 MYC LAG3 MTOR HK2 IFNG PMC5662495__F2 Mitochondrial Ribosomes in Cancer TNF FADD BAX PMC8601163__F1 Auxin‐mediated induction of GAL promoters by conditional degradation of Mig1p improves sesquiterpene production in Saccharomyces cerevisiae with engineered acetyl‐CoA synthesis GAL IPP GPD1 PMC3576161__F1 Folate metabolic pathway MTR FOLH1 MTRR PMC4774966__F5 Tolerant and Susceptible Sesame Genotypes Reveal Waterlogging Stress Response Patterns ECD EN2 ERFL PPIC PMC3022058__F1 Outline of UDP-GlcNAc synthetic pathways GNE OGT PMC1083933__F2 Cell cycle trials in Salamanca MOS CCNB1 CDC2 MYT1 PMC2293256__F4 Reannotation processes MTAP NADK NNAT PMC3888285__F2 Liver responds to iron signals to regulate hepcidin production BMP6 SMAD4 HFE ID1 SMAD1 DKFZp781O1323 TFR2 PMC5876067__F2 Inhibition of the BRCA1 DNA damage response pathway indicated by a down modulation (green; up-modulation is indicated in red) of atm, brip1, cdkn1a, e2f3, fancd2, fancl, mdc1, rad51, and rpa1 in male X ATM MDC1 ATF1 SHE PMC5131788__F2 Molecular mechanisms underlying alcohol-drinking behaviours NF1 DRD3 RET NPY GDNF HRAS BDNF PER2 PER1 PDYN PMC5540801__F4 Shh pathway targets and regulatory networks HHIP SALL4 BOC BMP2 TBX3 ETV4 ALX4 GAST BMP4 PTCH1 SHH SMO ETV5 ETS2 HAND2 PMC7816003__F1 Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1A signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats NRF1 TFAM UCP2 PMC8968515__F9 Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis MTOR ADM PMC5876695__F6 Meta-network illustrating synergistic interventions and resistance mechanisms to PI3K inhibitors BAD FOXO3A FOXA1 CDK2 MYC BCL2 PBX1 SGK1 MLL2 PMC7268490__F1 Schematic diagram of experimental workflow PLAT REN PMC5876695__F3 Network model of oncogenic signal transduction in ER+ breast cancer BAD FOXO3A FOXA1 CDK2 MYC BCL2 CDK4 PTEN SGK1 MLL2 CDK6 PMC9358906__F6 Type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway STAT1 STAT2 AMOTL2 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 WWTR1 PMC11208122__F12 Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3B signaling pathway JAK1 CD19 BAX PMC8767413__F4 Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence EGF CEBPB PMC4508501__F3 Altered steps in miRNA biogenesis lead to cancer DICER1 DROSHA XPO5 TARBP2 PMC7795003__F2 IGF-1 receptor, insulin receptor and hybrid receptor IGF1R IGF1 MTOR PMC4508501__F1 miRNA biogenesis process AGO2 DROSHA XPO5 PMC7795003__F1 Growth hormone (GH) receptor IGF1 PMC7795003__F3 Interplay of GH, IGF-1, insulin, hybrid receptor and nutrients in the muscle IGF1 SLC38A9 MTOR PMC8105775__F2 Caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems TH SLN NPS PMC8852737__F4 Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor PIK3R1 CCNA2 MAPK8 NR3A2 PGR EGFR TGFBR1 ALB MAPK14 BCL2L1 HEL-S-7 FGFR2 INSR RARA ITK NQO2 ERBB4 FGFR1 KDR NR1i1 MMP2 PTPN11 MDM2 SRC IL2 MAPK1 BST1 KIT BMP2 MMP9 GSTM1 PARP1 CTNNA1 HRAS CHEK1 AURKA HEL-S-22 CASP3 MAP2K1 IGF1 CDK2 TYMS JAK3 PLA2G2A PPARG PMC5840040__F3 Thermodynamic description of the eIF2B catalytic cycle ELF2 ELF1 SUI1 GIP PMC7753017__F4 Four pillars of sarcoidosis model CD14 TREM1 ATM MTOR PMC8511144__F7 Phenylephrine increases tear Cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway LAMP2 RAB27A RAB27B RAB3D PMC6981390__F2 The biosynthetic pathways (terpenoids, bitter acid, phenylpropanoids and flavonoid) in the hop BCAT1 STS IPP PMC11006979__F2 Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies STAT1 SMAD4 CDK9 CDK8 PMC7179464__F1 Macrophage migration inhibitory factor (MIF) and cancer pathway BAD CXCR4 CD44 IL8RB CD74 BAX PMC8147889__F3 Mechanisms of HBV-Induced Hepatocellular Carcinoma MAF KEAP1 GAB2 APC LRP5 GRB2 CCND1 LRP6 PTEN IRS1 FOXO1 STAT3 PMC9508091__F2 Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma OGT GNPNAT1 PMC9508091__F1 Mutant KRAS mediated metabolic alterations ME1 HEL-S-133P GLUD1 GLS PMC8196151__F3 Phosphoproteome analysis with equal loading TMT11 provides a comprehensive overview of cancer-relevant pathways BAD BRAF EGFR TP63 NFE2L2 GSK3B MYC PTEN RAC1 MTOR BRCA1 NQO1 RXRA NKX2-1 BCR ERBB2 MDM2 DSG3 CASP9 CCND1 ARAF RBL2 CD19 PMC9086968__F6 14,15-Epoxyeicosatrienoic Acid Protect Against Glucose Deprivation and Reperfusion-Induced Cerebral Microvascular Endothelial Cells Injury by Modulating Mitochondrial Autophagy via SIRT1/FOXO3a Signaling Pathway and TSPO Protein UBE3A CRY1 FOXO3A SMAD2 FOXO1 PPIF EP300 SUV39H1 PPARGC1A MDM2 PPARG SIRT1 PBR MYOD1 PMC7666984__F1 TLR4 signaling pathway (schematic) CD14 TLR4 IRF7 LBP TRAF6 IRF3 MYD88 TIRAP PMC4456452__F17 Pathway model for fly-wasp mediated social learning FMR1 AMN PMC9107748__F3A Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line ERBB4 SET MYC BARD1 PMC6232868__F1 Schematic representation correlating various factors such as light, eye, melanopsin, pineal gland, vitamin D, intestinal calcium, and gut microbiota to neuroinflammation and MS CD14 TLR4 TNF PMC2042178__F2 PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation PTEN MTOR STAT3 PMC5365005__F6 Sclareolide pathway enhances gemcitabine-induced gemcitabine-resistant human pancreatic cancer cell death RRM1 TWIST1 PMC9047489__F1 Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers SMAD2 GSK3B FOXC2 PMC8980082__F4 LncRNAs in the regulation of pyroptosis in NSCLC NLRP3 IL18 TLR4 RELA MYD88 GSDMD PMC8980082__F2 LncRNAs participate in the regulation of the apoptotic pathways in NSCLC BAD TRADD BCL2 FADD BAX PMC12024087__F9 Bta-Let-7d Modulation of Oxidative Stress Induced by Potassium Permanganate in Bovine Endometrial Cells via IGF1R/PI3K/AKT Signaling Pathway IGF1R BCL2 MTOR BAX PMC5295493__F2 Dietary triglycerides as signaling molecules that influence reward and motivation NGF ANKK1 TG PMC3165056__F4 Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity TRADD IRF7 TRAF3 TRAF6 IRF3 TRAF2 FADD PMC8027411__F9 RAB31 marks and controls an ESCRT-independent exosome pathway CD63 TBC1D2B RAB31 TBC1D28 PMC3589543__F7 A pathway choice model for repair of a DNA DSB in Arabidopsis SMC6 SMC5 PMC6160413__F6 Impact of osmotic stress on central carbon metabolism HEL-S-49 FBP1 ACO2 ENO2 GPD2 TIA1 CIT HEL60 MDH2 GPD1 PMC5651906__F8 PTP4A1 promotes TGFB signaling in DFs PTP4A2 SMAD4 SRC PTP4A1 PMC7216742__F3 Fyn signaling pathway ULK1 FYN ATG14 STAT3 PMC4586096__F1 G2E3 attenuating replicative stress G2E3 ATR RAD18 PCNA PMC5070123__F3 Major pathways affected in cancer- and drug-induced cachexia CASQ1 FITM1 TPM1 ACTN1 OBSCN TPM3 FBN1 COPA AMPD1 ASPN PYGB MYBPH HEL-S-104 MYH1 PRELP PYGM COX2 ACADS ACSL1 KRT82 KRT81 JPH1 KRT85 MYOZ3 ETFA TMOD4 KRT35 TMOD1 ETFB PLEC SNTA1 HEL-S-71 EHD2 PURA JPH2 ACTN2 GYS1 HEL-S-87p LMNA MYH6 MYLK2 ACADL MYOM1 HEL-S-273 PYGL ACADM PMC7492772__F3 NRX-based and LAR-RPTP-based synaptic organizing complexes display contrasting AB sensitivity BACE1 LRRTM3 NLGN1 ABO APP PMC10571814__F8 Oxytocin signalling pathway, with yellow boxes representing proteins identified in this study and green circles representing metabolites identified in this study MYL6B MYOF EEF2K BRAF DCLK1 EGFR OBSCN MYL2 MYL1 TNNC1 MYL3 TNNC2 RCAN1 COX2 SRC CCND1 TRPM2 MYL4 PLA2G4E MYL11 RNF123 MYOT EEF2 ARHA RGS2 CACNB3 CDKN1C MAP2K1 PLA2G4B OXT MEF2C PMC8228963__F8 Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NFKB Signaling Pathways Mediated by Gut Microbiota TNF IL1B PMC8834311__F5 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling FGF21 FGF23 ATF2 FGF19 PMC8834311__F4 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling FGF21 FGF23 ATF4 EIF2A PMC9124765__F2 Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis SMAD2 SMAD4 ARHA PMC8836129__F4 R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1 ATM WRNIP1 RAD51 ATR PMC7472464__F7 Overview of metabolic reprogramming in adipose tissue in EgPSC infected mice CS FH ACOD1 HEL-S-5 PMC6781720__F1 Schematic overview of the TLR4 signaling pathway CD14 TLR4 IRAK2 LBP TRAF6 IRAK4 MYD88 PMC5190013__F10 Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers MMP7 APC GSK3B MYC LRP5 CCND1 LRP6 PMC11769711__F2 Canonical Wnt signaling pathway and targeted therapy in AS APC LRP5 GATA6 LRP6 SOX9 PMC11769711__F1 Canonical and noncanoical TGF‐B signaling pathway and targeted therapy in AS (BMP signaling pathway is not shown) SIRT2 FGF21 CD47 SET GDF15 SMAD2 SMAD4 SLIT2 MTOR TF PMC11895685__F1 Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma IL9 IL13 IL33 IL2 IL4 IL5 TNF TSLP PMC4169059__F2 AC in vascular endothelium COX2 KEAP1 VCAM1 SRC NQO1 PMC7045390__F6 Correlation analysis of the hypoxic transcriptome and metabolome data HEL-S-49 HEL-S-26 DPP3 PGM2 ACO2 ENO1 PSD2 ARG1 tal-1 HEL60 HEL-S-32 HEL-S-68p PMC11758636__F9 Lin28b-let-7 Modulates mRNA Expression of GnRH1 Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells LIN28B KISS1 MTOR KCNJ3 PMC11769711__F4 Mechanistic models of AS NLRP3 POSTN MYD88 CTGF PMC7862327__F3 PI3K–AKT–mTOR signaling cascade and other related pathways involved in FCD HTR6 NPRL2 C16orf35 DEPDC5 PTEN EIF4E DEPTOR IRS1 PDPK1 RHEB INSR TSC2 TSC1 GRB2 PMC11769711__F3 NF‐KB signaling pathway and NLRP3 inflammasome in AS NLRP3 RELA TRAF6 GATA6 HDAC2 MYD88 PMC5753034__F6 DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages MCM2 CDC2 PMC11592033__F1 Image depicts a signaling pathway where neurotransmitters bind to membrane receptors, activating G-proteins and effector proteins to produce second messengers like Ca2⁺ and cAMP FOSB JUND JUNB PMC10145676__F1 Main metabolic pathways related to myo-inositol transformation inside the cell IP6K1 IP6K3 INPP1 IP6K2 IPMK PTEN PMC5572370__F7 Pathways of activation of naïve CD4+CD25+ T regulatory cell (Treg) (tTreg) IL5RA APC FOXP3 PMC3889256__F7 Rsu1 is a critical component for regulation of p38 Map kinase signaling from the IPP complex EGF PAK1 NCK2 HEL-S-28 RSU1 CDC42 PMC7866785__F7 Regulation pathway of CASC19 in the radioresistance of NPC PARP1 MTOR PMC3342364__F2 Molecular mechanisms mediating the regulatory effects of hypoxia RECK MSR1 CCL2 NOS2 ARG1 PMC9272703__F4 N-Glycosylation and Inflammation; the Not-So-Sweet Relation TH IL22 MGAT5 MGAT2 ST6GAL1 PMC5891174__F3 Crosstalk of DNA double‐strand break repair pathways in poly(ADP‐ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2‐mutated cancer RIF1 BRCA2 RAD51 BRCA1 PMC4283216__F1 GSK-3 family as therapeutic target for myocardial diseases HEL-S-28 SMAD2 APC MYC SMAD6 SMAD4 GSK3A ARHA PMC5373538__F2 Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NFKB in epicardial EMT PTPRS NAMPT CD99 PNOC PTPRK PXDN BPI PTX3 TGFBI PMC12052172__F4 Pathway network analysis based on genes annotated in eccDNAs RUNX1 BCR RUNX2 ERBB2 GRB2 RAC1 PMC6627365__F2 Epidermal Growth Factor Receptor-dependent activation of the MAPK signaling pathway EGF EGFR GRB2 CR2 PMC8750246__F1 AGEs-Induced and Endoplasmic Reticulum Stress/Inflammation-Mediated Regulation of GLUT4 Expression and Atherogenesis in Diabetes Mellitus AGER CEBPA TRAF2 XBP1 DDIT3 PMC6525811__F2 miRNAs that indirectly impact Alpha-syn without binding to its 3′-UTR TFEB ARHA FGF20 PMC2396219__F2 PPARA and AMPK activities in the cancer cells exposed to energetic stress TSC2 BAD TSC1 MDM2 MTOR IRS1 NR1C1 RHEB PMC4967820__F2 Gene repertoire for sterol biosynthesis in unicellular holozoans SQLE DHCR7 EBP DHCR24 SMO HSD17B7 TM7SF2 PMC8439554__F1 Mechanisms Contributing to MAC Pathogenesis ALPL MGP ENPP1 DDR1 RUNX2 ABCC6 GLA PMC6525811__F1 miR-7 playing a neuroprotective role in PD NLRP3 KEAP1 RELA PMC4382287__F2 Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection IKBKB MAPK9 MAPK12 MAPK13 MAPK8 PTGS2 RELA MAPK14 MAPK1 MAPK11 NOS2 TNF PMC4577305__F2 The Secretory Pathway Kinases FAM20C FGF23 FURIN DMP1 PMC6702336__F3 Summary of the role of the ERK1/2signaling pathway in CIRI MFN2 EGFR BAX PMC11923548__F10 Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway KEAP1 ATM GADD45A MTOR IRS1 PMC4267483__F1 Noonan syndrome BRAF GRB2 PTPN11 SHOC2 RAF1 SOS1 HRAS CBL PMC9045977__F3 Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer FES CYC1 LAT PMC7268158__F2 The JAK/STAT system in graft-versus-host disease CXCR3 NLRP3 HMGB1 FOXD3 CSF2RB CSF2RA CXCL11 IFNG PMC7268158__F1 JAK/STAT System EPO IL13 STAT4 TYK2 IL4 MPL IFNG PMC5771830__F5 Cancer cell metabolic changes linked to hyper-O-GlcNAcylation EGF OGA OGT MYC HIF1A PMC5036249__F7 Proposed mechanistic scheme of CA4 suppressing the Wnt signalling pathway in colorectal cancer WTAP WT1 CA4 PMC8301472__F2 Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update COX2 CCR10 MMP9 CCR4 CCL28 CD80 CCL22 ARG1 PMC4074217__F5 Comparison of apoptotic pathways and NLRP3 inflammasome activation NLRP3 MFN2 MAVS PMC6668984__F6 KEGG pathway enrichment analysis in signalling pathways DKFZp686L0365 STAT1 RAE1 NFKB1 SRC RAF1 PMC3458933__F7 Schematic overview of the results from the present study indicating WNT-5A secretion from astrocytes and the WNT-5A-induced signaling pathway towards ERK1/2 regulating distinct aspects of the proinflammatory transformation of microglia MMP9 PMC3123876__F6 Profiling experiments and pathway analysis EDAR PRSS1 PRSS2 EHF TUBB MED13 MED1 ST18 PMC6225658__F2 Representative image of the anti-angiogenic potential of autophagy PEG3 PMC3507178__F3 Flow chart depicting the metabolic pathway of fatty acids in the liver of GH transgenic Amago based on 3′-tag digital gene expression profiling and comparison of serum triacylglycerol and glucose, and 3-hydroxybutyric acid MID1IP1 ELOVL5 LPL ACSL1 ELOVL6 ELOVL2 TG HEL-S-5 PMC2759974__F1 MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer FOS APC WNT1 DHFR GSK3B MDM2 CCND1 CDK4 DMP1 JUN PMC8539290__F2 Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids MMP12 VCAM1 HEL-S-8a CASP9 DDT TRAF2 BAX PMC9655983__F9 Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway CXCL1 CCL2 TG IL1B PMC8983667__F1 Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway GNRHR ADCY1 GNAS REC8 PMC7578381__F6 Functionally grouped network visualization for epigenetically upregulated and downregulated genes TNFAIP6 OSCAR LAG3 LILRB2 TREML2 PKP3 KRT13 P2RX1 GNS HK3 KRT16 PPL KRT40 KRT78 KRT32 WIPF1 KRT76 BTLA FERMT3 PTPRC KRT3 CD300LF LILRA2 BIN2 ALDH3A1 PMC8448728__F5 PIGG defines the Emm blood group system PIGU PIGF PGAP1 PIGT PIGO PIGW PIGY PIGX PIGS PIGV PIGK PIGN DPM2 HEL-S-5 GPAA1 PIGC PIGH PIGM PIGA PIGP PIGL PMC5507646__F1 BRAF mutations in the context of mitogen‐activated protein kinase (MAPK) molecular alterations BRAF EGFR ROS1 PMC3388569__F3 Common biological pathways activated in OVCA cells in response to chemotherapeutic agents RET BAD SET APC SHE HRAS OPTN PMC4987202__F1 Axotomy activates the Wallerian degeneration pathway for the selective elimination and degeneration of severed axons NGF NMNAT2 SARM1 PMC3388569__F2 Shared biological pathway activation between chemotherapeutic agent treatments BAD APC HTR1A HTR2A PMC5675569__F3 Network of selected factors influencing myofibroblast survival/resistance to apoptosis SPARC CASP3 EGF PTEN TGFB1 THY1 PMC6414158__F4 ceRNA regulatory network associated with the MAPK signaling pathway ATF2 PPM1B PMC5891635__F1 Two working models explaining Sgg association with colorectal cancer (CRC) COX2 SLC10A2 PMC3822531__F2 Regulation of Wnt/-catenin signalling pathway.(A) Wnt forms a ternary complex with Fz and Lrp5/6, which promotes stabilization of Beta-catenin, thereby activating the pathway APC LRP5 LRP6 PMC6612304__F1 An integrative model of the roles of mitochondrial metabolism in liver cancer stem cells SOX2 MYC CD44 BCL2 HK2 HEL-S-162eP PMC6446925__F1 AMPK Signaling Pathway EEF2K EEF2 TRO PMC3756375__F2 Nerve growth factor (NGF) signaling in breast cancer cells NGF TRADD BEX2 PMC9449101__F1 Key Metabolic Regulator of Bone and Cartilage Health CAD pcap PMC8335742__F9 Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway NLRP3 IL18 KEAP1 GSDMD PMC6214712__F1 Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Cell Phenotypes RBPJ RUNX1 SOX2 RUNX2 CTCF CHD4 HSF2 UTF1 GATA4 GATA1 FOXA1 FOXL1 KLF4 BRD2 BRD4 PMC1754372__F2 Th1- and Th2-like lymphocytes, and the key regulatory cytokines and their interactions in SS IL10 APC IL6 IL1B IFNG PMC7853129__F6 CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFB SMAD2 TEC SRC FOXC2 PMC3199809__F1 The TGFB signaling pathway SMAD2 SMAD4 PMC8200556__F2 Genetic Determinants Highlight the Existence of Shared Etiopathogenetic Mechanisms Characterizing Age-Related Macular Degeneration and Neurodegenerative Disorders ARMS2 IL23R APOE PMC3650458__F1 Simplified overview of classical bile acid synthesis pathway in mice CYP8B1 AKR1D1 CYP7A1 PMC11763988__F4 Antioxidant role of butyrate in promoting animal health KEAP1 NQO1 BAX PMC5584166__F4 Signaling pathways that can cross talk with TNT formation TFEB FOXO3A PMC8139556__F1 PI3K Inhibition in the Treatment of Breast Cancer, Alone or Combined With Immune Checkpoint Inhibitors PTEN INPP4B MTOR PMC11560440__F4 Pathogenesis of SjD TLR8 PMC6605697__F7 Possible antifibrotic mechanism of exogenous hydrogen sulfide in diabetic cardiomyocytes GSK3B PMC3777178__F3 Multifunctional phosphorylated PDZ proteins integrate signaling pathways to control hyperplasia, neoplasia, and cell metastasis CDK2 SCRIB PTEN CDC2 PMC4508759__F1 Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host–pathogen standoff CGAS TLR9 IRF7 IRF3 MYD88 TLR3 MX1 RNASEL STAT1 RNASE1 TLR7 TF MAVS PMC4831356__F1 Schematic model illustrating O‐GlcNAc pathway and influence of glucose and O‐GlcNAcylation on chondrogenic differentiation OGA OGT SMAD2 SMAD4 PMC3576882__F4 NFKB: Roles and Regulation In Different CD4+ T cell subsets BCL10 CD80 MTOR PMC11837354__F1 Main metabolic pathway of catecholamine biosynthesis TH DDC DBH PMC11940455__F5 Signaling pathway activated by EGFR and TRKB receptors resulting in cell proliferation EGF EGFR GRB2 MTOR BDNF PMC8388553__F9 Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3B signaling pathway DKFZp686L0365 GSK3B BCL2 BAX PMC2668371__F9 The proposed model EIF4E MTOR RHEB PMC6914362__F10 Metabolic control of BRISC-SHMT2 assembly regulates immune signaling IFNAR2 HEL-S-51e IFNAR1 PMC3625980__F7 FBXW7A attenuates inflammatory signalling by downregulating C/EBPD and its target gene Tlr4 TLR4 NOTCH1 MTOR PMC11884102__F1 Signaling pathways in fibrotic processes involving macrophages SMAD2 MMP11 SMAD4 TNF MTOR PMC7830660__F1 Immune evasion by NSVs STAT1 TLR8 TLR7 STAT2 IRF7 IRF3 IL6 MYD88 JAK1 TLR3 MVP PMC4564644__F1 Diagram showing the possible mechanism of serotonin mediated signaling pathway activated by BME during learning AGO2 HEL-S-11 TPH2 CREB1 BDNF SYP PMC5107592__F1 Toll-like receptor signalling pathway TBK1 CD14 TLR4 TLR9 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 TLR3 TIRAP PMC12185857__F3 Fructose promotes systemic chronic inflammation NLRP3 TLR4 TXNIP TNF PMC7973006__F1 In stationary state, the aryl hydrocarbon receptor (AHR) is part of a complex composed by the 90kDa heat shock protein (HSP90), the co-chaperone p23 (p23) and the hepatitis B virus X-associated protein (XAP2/AIP/ARA9) AHRR AHR CYP1B1 TIPARP PMC11932893__F3 Regulatory mechanisms of AMPK in MASH-associated inflammatory response ULK1 MFF SMAD2 FNIP1 MTOR HDAC5 IL1B SIRT1 PMC11932893__F2 Molecular mechanisms of AMPK-regulated lipid metabolism ULK1 TFEB TXNIP FASN PMC5537006__F1 Top Ingenuity Pathway Analysis networks associated with genes whose expression is altered by high levels of miRNA expression associated with both TP53 and CpG island methylator phenotypehigh and/or microsatellite instability ZFYVE28 FGD4 RBMS1 GGH PPP3CC MYC TMEM14C TNFSF13 PARP4 UBE2V1 ATAD2 RUSC2 NXN ULBP3 PDCD11 RPS20 MSRB1 CLPB ADK GCLM UTP4 CDC42EP1 NSMAF TRPM6 AMOTL1 DACT3 TNFRSF17 BEX2 MLKL THAP1 SEPHS2 HUNK CLEC3B NLRP2 STX2 CARD6 TM2D3 BCAS3 DCTPP1 NOSIP MTDH SULT2B1 PHF20 ZNF346 GLA SRCAP CLIP3 AQP11 WDR12 NR3C1 DTX3 ELMO2 ZNF48 ELMOD1 GNL3L NSMCE2 NSMCE1 TM2D2 PPP1R14C SLC19A2 DAPK2 CDR2 UBA2 DLEU7 RNF112 NCS1 PMC12234872__F2 Cellular senescence and other age-related mechanisms in the pathogenesis of OP CCR5 GCA TPM1 FOXO3A DPP4 MAP1LC3A CTLA4 DNMT3B METTL3 TFEB opn LEPR SOX5 CXCL12 OSM TGFB1 CD24 PMC3236328__F2 The differentiation hierarchy within the mammary epithelium and potential relationships with breast cancer subtypes KIT ERBB2 RELB CD24 PMC9483046__F1 Research Progress on Exosomes in Osteonecrosis of the Femoral Head RUNX2 MSC CD34 PMC3236328__F1 Main NFKB-activating pathways TRAF3 RELB CD40 TNF TRAF2 TAB3 PMC7681022__F1 Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism TYMS PMC7526609__F2 IL-2 mediated JAK-STAT signaling pathway in COVID-19 associated male infertility.This figure shows IL-4 JAK-STAT Pathway and their effect on male infertility, during the event of infection by SARS-CoV-2 MAOA JAK1 STAT3 CD36 PMC8615515__F6 Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro AOX1 ATR BRCA1 PMC9034118__F1 Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma SUFU PTCH1 GLI3 SHH SMO PMC3429940__F1 Optimizing treatments for lymphangioleiomyomatosis TSC2 TSC1 CDK2 RHO HIF1A RHEB PMC6069177__F7 Phosphorylation of the HPV E6 PBM links cellular stress response signaling to E6 inhibition of p53 transcriptional activity ATM MDM2 ATR PMC8392322__F3 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia JAK1 FLT3 STAT3 PMC8392322__F1 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia STAT1 STAT2 STAT4 TYK2 JAK3 JAK1 STAT3 PMC4320493__F7 Proposed model of the distinct features of Hh signal transduction in insect, fish and mammal SUFU PTCH1 SMO PMC2807379__F8 Nephronophthisis: Disease Mechanisms of a Ciliopathy SUFU PTCH1 GLI3 SMO PMC2807379__F6 Nephronophthisis: Disease Mechanisms of a Ciliopathy APC GSK3B LRP5 LRP6 REST RHO PMC2807379__F4 Nephronophthisis: Disease Mechanisms of a Ciliopathy NPHP1 SHH PACS1 NPHP3 IFT80 PMC3554339__F1 Actions of Nec-1 and its derivatives in a mouse system RIPK1 TRADD TRAF5 CYLD RIPK3 TNF TRAF2 FADD IFNG PMC6096743__F5 Relationship between individual genes composing the ‘blood vessel development’ ontology group SCG2 ELK3 MEOX2 FLT4 CD44 S1PR1 EGFL7 ROBO4 LAMA4 THY1 PLXDC1 NR2F2 VEGFC GJC1 CAV3 ECSCR TNFAIP2 THBS1 EMCN TGFBR3 CXCL12 PRRX1 PMC6401500__F2 Activation of NFKB in ITME TRADD ATM TRAF3 RELB SSB TRAF6 CD40 TRAF2 PMC12226124__F4 Association of the inflammasome cascade with AD immunopathology NLRP3 IL18 NLRP1 AIM2 GSDMD PMC4955784__F1 Molecular and Genetic Inflammation Networks in Major Human Diseases PIK3R1 MUC1 EIF2S1 IGF1R PRKCE EGFR GSK3B EIF2B5 PTEN PNN EIF4EBP1 MTOR EIF2S2 PDPK1 PRKCA EIF2S3 RPS18 TIMELESS RPS28 RPS27A PTPN11 RPS6 AXL HSPA4 PRKAB1 PER1 CRY1 INPPL1 ACTR8 MAPKAPK2 SET CHEK1 RHEB TSC2 TSC1 CDC42 STAT3 PMC6548290__F1 MAPK and MST2/Hippo signaling, energy and glucose metabolism ENO1 ARAF KSR2 PMC10925886__F4 Lymphocyte behaviors and functions by the circadian clock IL10 CMIP BCR CCL21 CCR7 NFIL3 S1PR1 PMC10925886__F3 Myeloid cell behaviors and functions by the circadian clock CD99 CXCR4 CCL21 IL8RB CXCL2 CXCL12 PMC3552779__F1 Aerobic glycolysis, the citric acid cycle, and key glycolytic shunts F2 ENO1 PFKM HEL-S-133P PHGDH HK2 HEL-S-68p HEL-S-162eP PMC2704241__F5 Hepatic methionine metabolism and GSH synthesis HEL-S-61p PMC6317189__F4 Targets molecules of bta-mir-182 involved in the apoptosis signaling pathway CAPN5 PRKCE ROCK1 CASP9 BCL2 CASP2 CDC2 BCL2L11 HEL-S-31 CYCS PMC5713451__F1 Physiologic and oncogenic Hedgehog signaling SUFU PTCH1 SMO PMC2677399__F2 Nuclear Factor KB, Airway Epithelium, and Asthma IL16 RELA LTB RELB TNF PMC7557389__F9 Proposed pathway showing the effects of nanopriming with MWCNT–COOH on the membrane lipid metabolism of peatland boreal forest species in response to possible alleviation of seed dormancy and improved vigor PC PGP PSD2 LPA PSD PMC8229730__F2 New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes SOCS3 SF1 LEPR FOXO1 STAT3 PMC6966427__F1 B-cell receptor pathway BTK TLR9 BCR IRAK1 BASH IRAK2 TRAF6 SYK PLCG2 MYD88 MTOR PMC6631594__F2 In the absence of Hh signal, Patched1 (Ptch1) inhibits the Hh pathway through the modulation of the Smoothened (Smo) SUFU SHH SMO PMC3230808__F7 Regulation of CYP1A1 by capsaicin in Hepa-1c1c7 cells AHR EBP CYP1A1 TRPV1 CPZ PMC9259834__F1 Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies FST DCN SMAD2 SMAD4 MSTN MTOR PMC4632748__F3 Tamoxifen pathway and possible mechanisms of endocrine resistance in breast cancer cells PELP1 EGFR SRC PMC6334777__F4 Activating MAPK Pathway Mutations in LCH MAP2K1 ERBB3 CCR7 BCL2L1 ARAF PMC4632748__F7 Possible involvement of candidate microRNAs in tamoxifen resistance pathways, based on the present literature search and IPA analysis HOXB1 KDM3A EGFR CYP24A1 PAG1 CDK6 IGF1 PELP1 FOXA1 TIMP3 SRC BCL2 HOXA1 PMC3315189__F1 S-ADENOSYLMETHIONINE TREATMENT OF ALCOHOLIC LIVER DISEASE: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL HEL-S-182mP MAT1A PMC3397897__F8 Schematic presentation of signaling pathways and their downstream targets that are affected by a feedback loop between hBVR and PKCD PC FOS TNF PMC5601349__F1 Alternative pathways of gluconate-6P formation by dissimilation of glucose in Burkholderia FRK TNLG7C HEL-S-32 PMC4632748__F1 Simplified possible molecular signaling pathways (1 to 6) of estrogen (E) and estrogen receptors (ER) PELP1 EGFR SRC TF PMC3039708__F3 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics APC FOXP3 PMC3039708__F2 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics STAT1 TRAF6 PTEN MYD88 MTOR PMC5360632__F1 Combined Role of Vitamin D status and CYP24A1 in the Transition to Systemic Lupus Erythematosus RXRB NR1i1 GC CYP24A1 CYP27B1 RXRA PMC8217840__F1 LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease NFATC2 LRRK2 PMC4872230__F5 Identification and Characterization of miRNAs in Chondrus crispus by High-Throughput Sequencing and Bioinformatics Analysis UBC UCP1 HEL-S-28 LPL PMC7072741__F10 Postulated differences in the CXCR4-LASP1-AKT1 signaling between breast cancer and CML CXCR4 CXCL12 MTOR CRKL PMC5796629__F2 ROS generation metabolomics, transcriptomics, and metabotranscriptomics PRKCE EPO MPO UCP1 P2RX7 EGFR ALB RB1 VIP ACOD1 IL18 TLR4 SRC CALB1 PYY NOS2 IL4 APOE SNCA FGF2 CXCL2 ARHA PDE2A IKBKB IGF1 CYP3A4 PSEN1 NR1C2 BCL2 HTR2A PMC7425302__F2 Interferon G signaling pathway STAT1 PBRM1 STAT2 CXCL10 CXCL9 ARID2 IFNGR2 BRD7 JAK1 IFNGR1 IRF-1 IFNG PMC7425302__F1 Cancer resistance to immunotherapy APC IFNGR2 CD80 B2M IFNGR1 IFNG PMC8353790__F1 Adiponectin in psoriasis and its comorbidities: a review IL6 IL23R PMC8786287__F3 Metabolic adaptation of super-complexes SCAF1 ATF4 OPA1 PMC12245688__F3 Antitumor effects of HDACi PINK1 ACTA2 LIF NFE2L2 COL1A1 PSMB8 PMC3571454__F10 Models for intrinsic signaling by BST2 and for BST2 as a virus sensor BST2 MYD88 MAP3K7IP1 TRAF2 PMC12245688__F2 Action of HDACi on immune cells UBE2C LEF1 VEGFA COL1A1 ARG1 TCF4 BCL6 PMC6719619__F1 T-cell development TBX21 RUNX3 ZBTB16 GATA3 PMC3877719__F1 Analysis with NIH DAVID, Princeton GO term finder and Ingenuity Pathway Analysis yield similar gene enrichments, biological processes and pathways.The high confidence hit list was also analyzed by IPA for biological pathway enrichment DCLK1 PLCG2 UNG PADI4 AVPR1B ARPC4 PPP1R9B PLCB4 ITGB4 RRM2 EIF6 TRIM28 TRPA1 CA4 PMC6521789__F6 Mammalian PUFA synthesis pathway showing the n-3 PUFA pathway and the n-6 PUFA pathway, including the enzymes responsible for the elongation and desaturation steps FADS2 ELOA FADS1 ACD PMC8071059__F2 Priming effects of stress on NLRP3 inflammasome in microglia NLRP3 HMGB1 IL18 IL16 CCL4 CCL2 TNF IL1B PMC4681988__F14 Aspirin blocks signaling pathway involved in platelet activation as laid out by our algorithm INA F2R MAP2 MAPK3 F2RL3 GNGT1 HRAS PTGS1 GNAI1 PLCB1 RAE1 F2 MAPK1 RAF1 GNB1 PMC4042208__F1 Stress signaling pathways activated by electrophiles KEAP1 ATF4 EIF2A PMC9298969__F1 Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies GSK3B ARHA MTOR FOXO1 PMC2966904__F7 Proposed scheme of the signaling pathway by TfR2 and HFE HAMP HFE FURIN TF PMC11675435__F3 Nrf2 signaling pathway in RCC PRCC KEAP1 VHL HIF1A SETD2 CDKN2A PMC11675435__F2 KEAP1–Nrf2-ARE pathway in constitutive condition and under oxidative stimuli KEAP1 RBX1 PMC7246552__F1 Summary of methyl and methionine metabolism HEL-S-61p PC HEL-S-20 GAA PEMT PMC4135953__F10 The gene-to-gene networks of TLR3, TLR4, and poly(I·C) in mice immunized with UV-V after SARS-CoV challenge EREG DUOX2 IL1R2 PPP1R15A NLRP3 STAT1 NFKBID TLR4 GDF15 GBP2 RGS1 THBS1 RGS16 ADM IRF-1 CD14 PLAUR APC PHLDA1 CXCL2 HEL110 TREM1 NR4A3 CXCL9 CD40 GBP4 PMC6580702__F8 Negative regulators of NRF2 are found in autophagy RAB1A ULK1 ATG12 ATG3 KEAP1 ATG101 ULK2 ATG10 ATG9A DKFZp686F0183 TMEM41B RB1CC1 PMC2869521__F4 Solid tumors activate the NFKB pathway to maintain cell survival TBK1 CYLD RALB MTOR PMC2869521__F3 Constitutive NFKB pathway activation in multiple myeloma CYLD TRAF3 RELB CD40 CSA2 TRAF2 LTBR PMC2869521__F1 Role of BCR signaling to NFKB in ABC DLBCL BTK CARD11 BCR BASH TRAF6 SYK MTOR CD79B CD79A PMC1850774__F5 Convergence of signaling pathways BAD FYN HEL-S-28 GRB2 PTEN PMC2938013__F9 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development DISC1 GSK3B CDK5 DIXDC1 NDEL1 PMC2745765__F3 Linking the MGI and MouseCyc databases KL GAL PMC6704701__F6 Illustration of the mechanism of SOX2 promotion of breast cancer cell migration SOX2 NEDD9 RAC1 HIF1A PMC12172487__F1 Metabolic pathway of Sia and EV-D usage ST6GAL2 GNE CMAS ST3GAL3 SLC35A1 NANS GAL ST3GAL1 ST3GAL6 SIAT4C ST6GAL1 ST3GAL5 PMC8905560__F4 Prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis CD14 CS IRAK1 IRAK2 TRAF6 CD83 IRAK4 MYD88 MAP3K7IP1 CD69 TLR4 CD40 CD80 TIRAP TAB3 MAL PMC3699383__F1 Apoptosis pathways BAD FADD BAX PMC8205579__F7 Baicalin Magnesium Salt Attenuates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting of TLR4/NFKB Signaling Pathway IL16 TLR4 IRAK1 TRAF6 MYD88 TNF PMC8385203__F10 Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2Alpha-Stat3 pathway in diabetic cardiomyopathy OPA1 STAT3 PMC7725927__F1 mTORC1 signaling pathway TSC2 TSC1 ELF3 GRB2 RHEB PMC6756496__F3 Proposed signaling pathway in type II receptor cells CALHM1 TRPM5 TG PMC8741844__F1 CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway MCC ADA PMC7156451__F9 Glycogen metabolism regulates macrophage-mediated acute inflammatory responses STAT1 RARB GYS1 PYGL PMC2570299__F3 Role of GalGlyNAcPVv in V NAGK ABO GAL PMC10468807__F1 lncRNAs are involved in tumor cell lipid metabolism by targeting different signaling pathways ACSL1 MTOR TG RXRA PMC4452864__F2 TGFB and ROS interplay NOX4 FURIN PMC4835201__F10 A hypothetical diagram illustrates potential mechanisms in silicosis TLR4 MYD88 MTOR TICAM1 PMC6256271__F5 Targets of BA, JA, and BJ in the CD27 signaling pathway in lymphocytes CD27 APAF1 PMC5876306__F3 MYC and HIF-1 regulate glucose metabolism MYC HEL-S-133P HEL-S-162eP PMC7064563__F6 Metabolic pathways associated with EPS production in Phaeodactylum tricornutum FRK MPG NDP PMC9327618__F3 Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review RELB IL6 IL1B PMC10377333__F1 Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy HEL-S-90n KYNU AHR KMO IDO2 PMC12022316__F8 Mechanistic scheme of this study METTL3 IGF2BP3 DVL2 PMC4528072__F2 Model for the mechanisms leading from impaired regulation of the alternative pathway to hemolytic uremic syndrome (HUS) HEL-S-62p THBD FH VWF PMC3310792__F8 Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells PC TG PMC2677763__F7A Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways GPX4 KEAP1 ATF2 GPX1 ATF1 UGT8 ATF5 GPX7 BATF HEL-S-26 MAF HEL-S-2a ATF4 GPX2 EPHX2 HEL-S-44 JUN UGT1A1 EPHX1 FOS ATF3 GPX3 KLHL1 MGST1 HEL-S-64p HEL-S-75p HEL-75 PMC6520346__F6 Metabolomic analysis of in vitro effects of OPC-163493 in HepG2 cells ddo PMC8191541__F2 Viperin Reveals Its True Function STAT1 STAT2 IRF7 IRAK1 CMPK2 IRF9 TRAF6 IRF3 IRF-1 MAVS PMC4292778__F4 Gene network analysis of top HHT associated genes CASP12 STX6 NRF1 SPRY4 AKR1B1 CASP2 PRDX3 SIRT4 TRAF5 PAWR BANK1 AID UNK FADD SCD5 PMC8560908__F1 The interplay between NFKB signaling and ARTD family members TBK1 PARP14 PARP12 PARP10 RELB PARP1 MAVS PMC9083113__F8 Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease SMAD2 APP PMC11704404__F2 Autophagy initiation regulated by AMPK and mTORC1 TSC2 ULK1 TSC1 ATG101 ULK2 MTOR DEPTOR ATG14 RHEB MLST8 PMC11704404__F1 Schematic diagram illustrating the role of hepatic AMPK in regulating lipogenesis and lipolysis ACCS MTOR SIRT1 FASN PMC8138054__F3 Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances RGS4 EGFR GSK3B CD44 MTOR EPHB4 AGO2 KLF4 SHH CDH2 SP1 ABCB1 STAT3 CDC42 BAX PMC11003747__SF3_2 I6pDel p-proteome network analysis PRRC2C NCBP1 HDGFL3 EIF3A NASP EIF4EBP1 EIF4B SMARCC2 HMGN3 PMC11003747__SF3_1 I-ASD p-proteome network analysis THRAP3 EIF3A YBX1 PRPF40A CDK12 RBM25 SMARCC1 MLST8 PALLD RBMX SOX5 RPS6 ZC3H18 BRD4 PMC5484669__F3 Signaling pathways that are key regulators of pluripotency in mESCs SOX2 LIF TBX3 PMC7098997__F4 Changes in proteins involved in the oxidative stress metabolic pathway MPV17 PTS PEX19 PEX6 PEX5 PXMP4 PEX2 PEX3 PEX14 PMC7098997__F3 Changes in proteins involved in carbon metabolism and oxidative stress metabolic pathway DLD MAL PMC3829115__F1 Schematic overview of TF signaling complexes TFPI APC TF PMC8560908__F5 The interplay between AKT signaling and ARTD family members TSC1 GSK3B PARP2 PARP1 SIRT1 FOXO1 PARP3 PHLPP1 PMC8560908__F4 The interplay between MAPK signaling and ARTD family members PARP14 MOS ATF4 PARP1 TNKS2 PMC8560908__F2 The interplay between JAK/STAT signaling and ARTD family members DTX3L STAT1 PARP14 HDAC3 PARP11 HDAC2 PARP1 CP PMC8637879__F2 Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy NLRP3 TXNIP GSDMD DFNA5 PMC4365493__F8 The signaling pathway through which MIF increases vascular permeability CXCR4 CD44 IL8RB MTOR CD74 DKFZp686F0183 PMC8294384__F6 Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens) CYP3A4 CYP1A2 CYP2E1 PMC2974170__F1 Diagram of TLR signaling pathways TBK1 TLR9 IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 TIRAP PMC2398704__F3 High and low pollen-hoarding strain bees PIN1 IGF1 PIN4 PMC7535936__F5 Schematic outline of the Nodal signaling pathway in vertebrates NODAL SMAD2 SMAD4 GDF1 GDF3 FOXH1 PMC3364883__F2 Protein processing in endoplasmic reticulum is altered in Manf mutants SEL1L ATF4 SVIP SP1 PMC10650070__F2 NFKB, MAPK and Oct-1 pathways for expression of Beta-defensins LTA MYD88 PMC12218123__F1 Folate metabolic pathway; connection between the folate cycle and methionine cycle CTH HEL-S-61p PMC3364883__F5 Gene expression alterations in Manf mutants with a linkage to Parkinson's disease SNCA CASP9 PMC3364883__F4 Changes in gene expression related to endocytosis in Manf mutants LDLR DEPTOR OTP VPS36 PMC8126649__F1 Biological Characteristics of Umbilical Cord Mesenchymal Stem Cells and Its Therapeutic Potential for Hematological Disorders CDK4 CDK6 PMC4120774__F6 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC PDK2 MTOR PMC4263370__F6 SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies ADIPOR1 ADIPOR2 TLR4 LPA NR1C1 PMC4154379__F9 Tumor Necrosis FactorA Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor-Beta-activated Kinase 1 (TAK1)-dependent Signaling Pathway TRADD TNF TRAF2 FADD PMC4120774__F9 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC APC MYC CCND1 PMC3376488__F6 TRIF signal pathway ATF2 TRAF6 IRF3 PELI1 JUN FADD TLR3 TAB3 PMC5846637__F7 PD0332991-regulated gastric cancer cell signaling networks DDR1 NGF APC CCND1 PTEN CP BAX PMC3376488__F5 MyD88 signal pathway ATF2 TRAF6 IRF3 IRAK4 MYD88 TNF MAP3K7IP1 IRF4 TAB3 MAL PMC3376488__F2 T-cell development and differentiation IL16 IL6 SOS1 STAT3 PMC7557985__F11 Differential mechanisms of CK2.3 in osteoblastogenesis and osteoclastogenesis RUNX2 DCSTAMP PMC3316585__F1 Formal Modeling and Analysis of the MAL-Associated Biological Regulatory Network: Insight into Cerebral Malaria BTK TLR4 MAL PMC7780025__F1 Mammalian Hippo‐YAP signaling network TEAD3 AMOT YAP1 NF2 SRC TEAD4 SCRIB LATS1 LATS2 TEAD2 PMC8641375__F7 Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice TLR4 RAB5A MYD88 IL1B PMC6196654__F1 Network of the two sets of top genes with P-value < 0.01 in the case–control and family-based analyses focusing on rare, deleterious variants INHBC NOTCH4 VNN2 THSD4 GANAB ENG MSTN IFT140 GNG3 IFT43 SEC16A CHRM3 WDR35 INHA GRB2 PMC11872695__F1 Illustrates the interplay between gut microbiota, ImP production, and cardiometabolic diseases FGF21 CX3CL1 EGFR PMC6260573__F7 Flavonoids downregulate mdr1 expression through wnt/Beta-catenin signaling pathway APC LRP6 FZD1 PMC10499775__F1 Illustration of the Fas-FasL pathway CASP10 MTOR CASP8 FADD PMC90529__F7 Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray GIG8 IPP COQ7 PMC7769200__F8 Schematic model illustrating the biological roles of the hsa_circ_0000714/miR-370-3p/RAB17 regulatory axis in A2780/PTX paclitaxel-resistant ovarian cancer cell RAB17 CDK4 CDK6 PMC11326265__F7 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates H6PD PTBP1 ENO1 HEL-S-87p PDK4 SLC16A3 HEL-S-162eP PMC3240145__F2 Intrinsic and extrinsic pathways of apoptosis DIABLO FADD BAX PMC4674284__F1 A working model of how the NLRC5 ubiquitination and deubiquitination feedforward loop shapes IKK/NFKB activity TLR4 TRAF6 TRAF2 PMC3563666__F4 Altered Cytokine Gene Expression in Peripheral Blood Monocytes across the Menstrual Cycle in Primary Dysmenorrhea: A Case-Control Study GDF5 BMP6 PTGS2 SMAD4 TNF HMOX1 NR1C1 BMP4 CASP3 BMPR2 EP300 MMP2 HEL-S-44 CASP9 BCL2 PPARG SMAD1 CASP8 TF PMC4559943__F1 Schematic diagram of the assembled modules to convert galactose to n-butanol HBD GALP PMC3689941__F9 STAT3 pathway switching is induced by EMT during breast cancer progression EGFR SRC STAT3 PMC8461988__F1 Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis CD14 LTA TLR4 PTGS2 EGFR PMC8646045__F7 Activation of A7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats COX2 CD163 IL1B CD68 PMC3775430__F5 Model for possible sequence of genomic events in PCA progression ERG PTEN TMPRSS2 PMC5543755__F5 Protein complex analysis EPN2 KCNA4 DLG2 FRS2 FOS HGS ARC CUX2 CRIPT DLG4 PMC5543755__F4 Merged mouse and rat network (mapped to human proteins) and overlapping Reactome pathways RRAGD CS MTOR DRD2 CCKAR PREX2 EPN3 NUBP2 STAU1 HABP4 NARF ARC NUBPL NTRK2 PMC7070911__F1 Metabolic pathway and mechanism of action of Clopidogrel CYP2B6 CYP2C19 PMC5999788__F2 Integration of actions of PKD1 and PKD3 in cardiac energy metabolism—a hypothetical scheme HDAC7 SRC PKD1 HDAC5 CD36 PMC9337250__F4 Bile acids and sphingolipids in non-alcoholic fatty liver disease S1PR2 S1PR1 RHO PTEN S1PR4 PMC9314780__F3 Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations KL VIT FGF23 IGF1R IGF1 PMC9673322__F7 Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis TRAF6 CD40 IL1B PMC9337250__F2 Bile acids and sphingolipids in non-alcoholic fatty liver disease CYP27A1 GCA CYP8B1 CYP7B1 BAAT CYP7A1 PMC7699465__F1 Nelfinavir inhibits the Nrf1-dependent synthesis of proteasome subunits and inhibits the proteasome, leading to accumulation of misfolded proteins that activate IRE1A and PERK arms of the UPR NRF1 SMAD2 TRIB3 HIF1A MTOR RET CDK2 ATF4 EIF2A MDM2 SESN2 PCNA STAT3 PMC3775430__F1 PI3K/PTEN/Akt pathway PTEN MTOR PMC7222024__F4 Sugar and lipid metabolic pathways affected by oxygen availability SCARB1 LDLR CD36 PMC5773247__F1 Wnt Signaling in Cardiovascular Disease: Opportunities and Challenges USF1 RUNX2 LRP5 KLF5 LRP6 RYK ARHA RAC1 MTOR MSX2 IL4 JUN CDC42 PMC9688074__F7 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases TLR4 hCG_1998026 IL1B PMC9688074__F6 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases NKAP TLR4 MAPK14 TRAF6 IL1B PMC9688074__F8 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases NLRP3 IL1B TGFBI PMC12027412__F9 Pathway enrichment analysis and protein–protein interaction among active components and common targets in prostate cancer GRB2 SRD5A2 PTEN PMC6978272__F8 How CSF induced accumulation of endosomes, autophagosomes, and lysosomes, which led to increased intracellular AB accumulation APP UVRAG IAPP PMC12027412__F4 Component–target–pathway–disease network diagram KLK3 CCND1 PIK3CA PMC9688074__F1 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases TLR4 TRAF6 PMC9688074__F3 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases NLRP3 STAT3 PMC5412778__F2 Neural ectoderm and neural crest specification in deprivation of the external signals.A SOX2 GBX1 KRT7 MIXL1 DKK1 PAX3 SOX17 FOXA2 ZIC1 CDX2 GSC OTX2 SMAD1 PMC7729224__F2 Cyclic adenosine monophosphate (cAMP)-cAMP response element binding (CREB)-miR-21- programmed cell death protein 4 (PDCD4) axis PTEN MTOR PMC2386254__F11 A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage HEL-S-62p ARHA NET1 PMC5949363__F7 Interaction between T follicular helper (Tfh) and B cells initiating synergetic effect of IL-21/IL-21R and CD40 ligand (CD40L)/CD40 to promote plasma cell differentiation and antibody production in EAE PC MOG BCR HEL-S-11 CD40 SYK ICOS PMC6289701__F2 Mammalian mTORC1-dependent ribosomal transcription MAF CHD4 MTOR POLI PMC7729224__F3 Wnt/Beta-catenin-c-Myc-miR-17∼92 axis MTOR NR1C1 PMC7901767__F1 Evidence that a naturally occurring single nucleotide polymorphism in the RagC gene of Leishmania donovani contributes to reduced virulence FLCN SH3BP4 DEPTOR PMC1636614__F8 Schema of Ang II-induced NFAT activation in cardiac myocytes C6 NACA2 TRPC3 PMC5686148__F8 Working model PLK1 FOXM1 CDK2 CDC2 PMC9250990__F1 T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease CGAS PDC TLR7 TLR9 APC IRF3 IFNG PMC3042129__F8 Unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening ANXA1 KIF23 HEL2 F2RL1 ENO1 EEF1A1 CENPE RB1 LMNA TOP2A MMP17 PS1TP5BP1 RFC3 CASP3 MCM2 ANXA2 SERPINA1 RAD21 SERPINB3 PCNA KRT10 PMC9067156__F9 UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines SNAI1 PLA2G15 UGDH NR1C1 PMC7865460__F1 Multiple myeloma (MM) cell metabolism compared to normal plasma cells HEL-S-133P HEL-S-281 PMC7865460__F3 General metabolic effects of MM-associated oncogenes MAF GSK3B MYC FGFR3 CCND1 CDK4 CDK6 CCND2 PMC4984448__F2 Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children PINK1 MFN2 DKFZp686F0183 OPA1 PMC9177993__F1 Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels SPO11 ATM HORMAD2 ATR PRKDC PMC5131988__F2 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy WSB2 EPHX1 DGKD FKBP5 DOCK1 MAGOH PGRMC1 CAMK1 TARBP1 NBPF10 RPL12 RGS5 PPP3R1 MT1E RPL21 USP46 RPL26 SRSF7 PICALM RPS3 CP PMC10975175__F2 Heat stress triggers nitric oxide (NO) production and increases calcium levels DCD CS NOA1 PMC5131988__F3 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy PPP3R1 CABIN1 LIF GSK3B CTF1 SRC NACA2 HAND1 GATA4 PMC10889199__F1 Endothelial cell senescence CDK4 MTOR SIRT1 CDK6 PMC8275185__F11 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant DLK2 SKP1 LAT PMC4761146__F9 Schematic diagram depicting the proposed signaling pathway involved in interferon-induced transmembrane protein 1 (IFITM1) upregulation in SUM149 cells STAT2 IRF9 TYK2 IFNAR2 IFITM1 PMC7683115__F6 lncRNA-miRNA regulation mechanism diagram based on the insulin signaling pathway INS INSR PMC7683115__F7 lncRNA-miRNA regulation mechanism diagram based on the AGE-RACE signaling pathway PIM1 TGFBI STAT3 PMC1553448__F7 Transcript expression of BMP signaling pathway members DCN BMPR2 GIG8 ID4 BMPR1A TGFBR1 TGFBR2 SMAD4 ID1 ID3 PMC11899777__F4 Comprehensive Review of Fc Gamma Receptors and Their Role in Systemic Lupus Erythematosus BTK SRC SYK RHO PMC5153335__F1 KRAS pathway biology BRAF ICMT RCE1 MTOR PMC4374654__F3 Emerging regulators of the inflammatory process in osteoarthritis EIF2A XBP1 IL1B PMC3936936__F1 Network of interactions between products of candidate genes from the QTL regions PIK3CD PLG MTOR HEL-S-7 SERPINE2 IFNG PC LYN CCL20 STX11 IL22 APP IL2 PTPN6 C1S EPHA2 PMC7218278__F1 “Confidence view” of the protein-protein interaction network on String.The thickness of the blue line between 2 nodes indicates the level of confidence of association between these 2 SOCS3 ESRRA LCP1 RAP2A CEBPB TYROBP LCP2 BPIFB2 IL33 REL PPARG SP3 CERS2 PMC7232545__F1 Anticancer mechanisms of matrine HMGB1 EGF CASP6 BAD ATG12 MMP9 EGFR GSK3B LRP5 PTEN MTOR DKFZp686F0183 CDK6 CASP3 LEF1 MMP2 CDK2 CASP9 CDK4 TRAF2 CASP8 PCNA STAT3 PMC9237220__F1 Different Immunoregulation Roles of Activin A Compared With TGFB SMAD2 SMAD4 MTOR PMC7545984__F2 Pro-fibrotic roles of the GSK-3B signaling network in fibrosis DKFZp686L0365 PMC3257109__F3 BMP signaling in motor neurons LIMK1 BMP2 SMAD4 BMP7 SMAD1 DKFZp781O1323 TRIO PMC8560861__F8 Model summarizing the pathway described in this study along with known effects of CCL20 and CXCL8 signaling in the context of cancer CXCR1 CCL20 CXCL8 STAT3 PMC6935755__F2 Ragulator complex in SEGAs ULK1 BRAF HEL-S-1 BIRC5 LAMTOR3 PRKAA1 AKT1S1 ATP6V1C1 EIF4EBP1 ATP6V1C2 ATP6V1E1 LAMTOR2 CASP9 ATP6V1A PRKAG1 LAMTOR5 ARAF PRKAG3 PRKAB2 PRKAB1 SLC38A9 ATP6V1E2 ATP6V1D MAP2K2 EIF4E IRS1 RHEB MLST8 WDR83 TSC2 RPS6KB1 TSC1 ATP6V1B1 LAMTOR1 ATP6V1G1 LAMTOR4 PRKAG2 RAF1 ATP6V1G3 RRAGA ATP6V1F RB1CC1 PMC7545984__F1 Anti-fibrotic roles of the GSK-3B signaling network in fibrosis HEL-S-28 GSK3B BCL2 SGK1 SIRT3 PMC10982457__F1 Viral RNA‐driven peripheral serotonin reduction impairs neurocognition by directly dampening vagal signaling ACE2 TLR3 PMC3982501__F4 Receptor tyrosine kinase (RTK) signaling pathway is frequently hit by lentiviral vector (LV) integration BRAF MDM2 GRB2 MAP3K8 PTEN MTOR PMC10035551__F1 Regulation of PD-1 and PD-L1 expression in sepsis APC ZAP70 CD80 PMC10960957__F5 Ferrihydrite-mediated methanotrophic nitrogen fixation in paddy soil under hypoxia GCK TNLG7C HPR PMC6695603__F1 Epidermal growth factor receptor (EGFR) pathway in non-small cell lung cancer (NSCLC) EGF ERBB4 ERBB2 EGFR MTOR PMC6751247__F7 Schematic description of TLR7-mediated enhancement of CD8+ T cell function TLR7 MYD88 MTOR IRF4 IFNG PMC6695603__F4 Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC) EGF ERBB4 AREG ERBB3 EGFR CDC2 CDK9 PMC8764384__F1 Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation ATF4 EIF2A XBP1 PMC8568770__F1 Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia TRPV4 GPR55 FAAH TRPV1 GPR18 PMC7798029__F1 Suppressive activity of MDSCs induced by the TLR2 and TLR4 signaling pathways TLR4 S100A8 MYD88 JAK1 ARG1 S100A4 MPL STAT3 PMC5613704__F1 Acute and chronic effects of plasma Ang II, aldosterone and EO on brain angiotensinergic pathways AVP NTS BDNF PMC6036268__F6 Pectin oligosaccharides (POS) downregulates the expression of nuclear factor-kappa B (NFKB) and COX-2 by binding toll-like receptor 4 (TLR4) TBK1 TLR5 TLR4 IRAK1 MYD88 TNF TLR3 MAL PMC7312564__F2 Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis C6 CEBPA PMC10030845__F2 Inflammasome and pyroptosis in autoimmune liver diseases NLRP3 IL1B GSDMD PMC10030845__F1 Inflammasome and pyroptosis in autoimmune liver diseases NLRP3 TLR4 NLRC4 NLRP1 NLRP6 MYD88 GSDMD PMC7982061__F2 Notch1 signaling pathway and Notch1 inhibitors DLL4 JAG2 MYC ADAM10 FURIN DLL3 CCND3 PMC4091181__F10 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells PPARGC1A GABARAPL1 PMC6082390__F2 PC1/3 activity is essential to the leptin–melanocortin pathway POMC NPY AgRP MC4R ARC PMC6205410__F1 Four hyperglycemia-induced pathogenic pathways which are related to overproduction of ROS and inflammation progression in atherosclerosis TLR4 CRP HEL-S-162eP PMC11460135__F8 Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway GPX4 HOXC11 BAX PMC6205410__F2 Downstream products of ROS promote endothelial cells (ECs) dysfunction in atherosclerosis KLF2 MTOR RHEB PMC9204952__F9 Genome-wide association mapping and genomic prediction for pre‑harvest sprouting resistance, low Alpha-amylase and seed color in Iranian bread wheat BIN2 EBF2 TF PMC8126329__F1 Analysis of the Protein–Protein Interaction Network Identifying c-Met as a Target of Gigantol in the Suppression of Lung Cancer Metastasis PARVG GPC4 ODZ1 LAMB2 CELSR1 DSC2 PCDHB7 BLK ITGB1 FAT4 CDH19 PKP2 LAMB1 PKP4 PKP3 PLXNA1 MSLN PCDHGC3 ARVCF PCDHA9 LAMC1 DSCAM PARD3 PMC8001214__F3 Mechanisms of aging-associated salt-sensitive hypertension and crosstalk between Wnt noncanonical pathway and angiotensin II (Ang II)-induced vasoconstrictive pathway LRP5 TPR LRP6 ARHA ROR2 IL1B PMC11120279__S1 FDT vaccine with the ability to activate systemic immunity for tumor inhibition APC IFNB1 MERTK PMC5490578__F7 Simplified diagram of the lipid metabolism canonical pathway PLTP PON1 APOD TG APOE PMC4865921__F9 Schematic summary of the results CASP3 NGF LDLR CASP2 PMC8463275__F2 Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy KIT MYC SSB CDK12 MTOR BRCA1 CDK7 CDK6 CDK2 CDK4 CDC2 CDK9 FDXR PMC12001097__F4 Inflammatory cytokines and activation of PI3K/Akt pathway by Yiqi Jiedu Formula in recurrent Herpes Simplex Keratitis: Experimental and network pharmacology evidence PIK3R1 CHUK NGF EGFR CREB1 PTEN COL1A1 FGFR2 TNFSF6 TLR4 FGFR1 KDR IL2 IL4 FGF2 VEGFA RAC1 IL6 BRCA1 IKBKB ERBB2 NFKB1 PIK3CA BCL2 BDNF PMC4951304__F1 Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint DKK3 CDK2 MYC CCND1 CDK4 CDK6 PMC2564829__F7 Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells ACACA ATR PMC1971124__F4 BDCA2/FcERIG Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells PDC CARD9 FYN BCR BASH LCK LYN ZAP70 SYK BLK LAT PMC10956371__F1 UPR signaling pathway ATF4 EIF2A XBP1 PMC8085316__F2 Adapting T Cell Receptor Ligand Discrimination Capability via LAT LCK LAT PMC11555832__F4 Facilitating tumor cells recognition by innate immune cells CGAS TLR9 IRF7 TRAF3 TRAF6 RIGI IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TRAF2 PMC11555832__F3 Resistance to PD-1 blockade in CRC PTEN B2M PMC9240433__F8 Breast Meat Fatty Acid Profiling and Proteomic Analysis of Beijing-You Chicken During the Laying Period APOA4 TNNC1 CPT2 TNNC2 ABHD2 PLA2G7 ACAT1 ACSL1 FABP5 ANXA1 ACOT7 ECHDC1 SLC25A4 CASP3 APOB PPP3R1 PHKB ACADL CPT1A PECR ATP2A2 SPHK1 TECRL ABCD2 CD36 PMC3928697__F5 Proposed pathway of CD33 siglec-mediated suppression of cellular function in Leishmania infection SOCS3 CD33 SIGLEC5 IFNG PMC7836502__F6 Production of PA and DGPP by different pathways and interconversion reactions mediated by phosphorylation and dephosphorylation PI3 PC HEL-S-11 CA8 CA3 CA9 OCRL LPA CA12 CA7 PMC3070284__F2 Endothelial growth factor receptor (EGFR) signaling pathway EGF EGFR GRB2 MTOR PMC8814392__F2 Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration NAPSA PTGFR AP3B2 HAL ALOX15 HSD11B1 CXCL3 HDC CYP26B1 LIPG CD2 B3GNT5 P4HA3 PIGA ALDH1A2 CTSW PAPSS2 FBP2 BDH1 FUT4 HEL-S-130P PHGDH GSTM2 IPPK GNA15 CTSC CD7 ADA SPHK1 MME PMC7399786__F7 Roles of miR-33a and its target genes in prostate (top) and breast cancer (bottom), and the underlying mechanisms PIM1 EIF5A2 ADAM9 CPT1A HADHB TGFBR1 EZH2 EN2 ROS1 PMC6242703__F1 Simplified diagram of transcriptional pathways and targets for intervention for AUD treatment CORT NPY BDNF PMC6592474__F8 Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness ATF4 TRAF2 XBP1 PMC4950926__F6 Schematic presentation of mechanisms of actions of CTS IGF1 TPM1 MYOG MYOD1 PMC7688141__F8 Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway SOX2 KLF4 PMC5955995__F4 MAPK Signaling pathway showing expression pattern of DEGs in Ladakhi and Sahiwal cows CD14 EGF PRKCZ BRAF SOS2 RASGRF2 FOS MAPK14 MIP OPTN CRK NLK NTF4 NF1 MINK1 MAPK12 ECSIT MAPK11 PRKCH MEF2C JUN PMC8269279__F6 Roles of Pseudophosphatases in Disease STYX CDH2 CELF2 FBXW7 STYXL2 PMC1069621__F5 Two models for coupling of circadian and cell cycles TIMELESS WEE1 CRY2 ATRIP ATR PMC3525180__F3 Some perifosine-specific genes are connected by common pathways leading to MAPK signalling pathway and apoptosis NFATC4 IGF1R MPDZ ATF2 MAPKAPK3 PMC8251784__F4 In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae CD207 NOD2 PMC4694853__F8 Non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation RPS6 MTOR PMC4891982__F4 Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage ME2 PC ME3 CIT MAL PMC6790656__F3 Biological applications of light‐induced dimerization systems CRY2 ARHA RAC1 PMC12115990__F3 TRIM25 regulates the RIG-I- and MDA5-mediated antiviral and TRAF2/TNFA signaling pathways TRAF3 TRAF6 IRF3 TNF TRIM25 TRAF2 MAVS TRIM65 PMC7139810__F7 Reciprocal link between the serine biosynthesis pathway (SBP) and MYC oncogene PSAT1 ATF4 EZH2 PHGDH PMC12115990__F2 Biological functions of TRIM25 in SARS-CoV-2 infection and cancer cell survival MAF GPX4 TFEB IRF7 KEAP1 IRF9 MDM2 IRF3 TRIM25 MAVS PMC1774101__F4 Proposed framework for recruitment of T cells into the gut mucosa by activated CD40L+ platelets CCR5 CCR3 VCAM1 CD40 PMC4055851__F2 Resistance to anti-EGFR moAbs in mCRC EGFR PTEN MTOR PMC3616974__F6 Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB DLEU7 KPNA3 KCNRG TAB3 PMC6779808__F6 Network analysis from RNA seq EXO5 NFE2 HSPA14 FOXJ1 RBM5 UBTF TNFRSF10D ZNF74 TUT4 NPAS1 RAD52 HSPA1A NBPF3 PMC8869286__F1 Identification of Targetable Liabilities in the Dynamic Metabolic Profile of EGFR-Mutant Lung Adenocarcinoma: Thinking beyond Genomics for Overcoming EGFR TKI Resistance HGF EGFR LDLR FASN PMC6156122__F2 Pathways to retinal regeneration ASCL1 SIX3 LAT PMC10260623__F1 Schematic of the clock pathway DBP NPAS2 NR1D1 TF PMC8044762__F2 cGas-STING activation pathway ENPP1 IRF3 ATG9A PMC8372643__F2 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy F2 DLL4 HIF1A PMC5600417__F1 GO biological process and KEGG pathway enrichment analyses of the differentially modulated proteins at 6 and/ or 12 h of treatment with A233 peptide NABP1 HEL-S-97n HADHB ARHGEF2 EEF1E1 HSPD1 NABP2 HEL-S-104 HEL-S-128m HEL-S-32 FCER1G ACAT1 HEL-S-44 PCK2 DLAT HK2 HEL-S-281 BAX RUVBL2 AKR1B1 PFKL COXFA4 NDUFA2 VCP ECHS1 MAVS PMC8372643__F3 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy F2 APC PMC2212359__F5 HToll and TNFR-1 signaling pathways TRADD ATF2 TRAF6 MYD88 TRAF2 PMC209410__F1 The EXT proteins and HS biosynthesis CS EXT2 EXTL2 EXT1 GAL PMC9682092__F4 LncRNAs involved in regulating the RIG-I signaling pathway IRF7 MAVS PMC9682092__F3 LncRNAs involved in regulating the RIG-I signaling pathway TBK1 IRF7 IRF3 TUG1 MAVS PMC6262346__F1 Metabolic pathways involved in glucose, fructose, and xylose catabolism in B XYLB RPIA HEL107 RPE PMC209410__F2 A working model of mammalian bone development IHH EXT2 EXT1 SMO PMC9682092__F2 LncRNAs involved in regulating the RIG-I signaling pathway STAT2 IRF7 IRF9 GSTM1 SFPQ IRF3 IFNAR2 IFNAR1 TRIM25 STAT1 TYK2 JAK1 MAVS PMC8884404__F1 Molecular Pathways of Pyroptosis in Atherosclerosis NLRP3 ARHA AIM2 GSDMD PMC9682092__F1 LncRNAs involved in regulating the RIG-I signaling pathway TBK1 IRF7 TRAF3 IRF3 TRIM25 MAVS PMC3227927__F1 Signaling pathways and effects of EGFR EGF EGFR HBEGF PTEN TGFA PMC8998691__F3 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway PLCG1 BAD BRAF NGF HEL2 IRAK1 TRAF6 PLCG2 RIPK2 CRKL TNFSF6 PTPN11 KIDINS220 NTRK2 JUN ARHGDIB BAX MAPKAPK2 MAP3K1 MAP2K5 NTRK3 ARHA RAC1 CRK IRS1 CALM1 NTF3 NFKBIA MAP2K1 PSEN1 RELA GRB2 TP73 PIK3CA BCL2 SHC4 SHC1 CDC42 AKT3 PMC9368823__F2 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers TSC2 RICTOR TSC1 DDIT4 RHEB PMC8998691__F2 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway MGA PMC9368823__F1 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers APC GSK3B LRP5 LRP6 FZD4 TCF4 FOXA2 PMC4126464__F10 Metabolic redistribution in Synechococcus sp CIT IPP MAL PMC3728221__F8 Working model for the synergistic effect of TPL and ATF on tumour cells CASP3 CASP9 CCND1 FADD SKP2 BAX PMC8872821__F1 Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’ AMFR SPRY1 CCL1 PMC8280127__F8 HOTAIRM1 working mechanism ROCK1 ARHGAP18 BCL2 ARHA BCL2L11 PMC8069526__F5 RNAs that regulate nonhomologous end-joining (NHEJ) SBF2 PMC4277354__F6 ReNE: A Cytoscape Plugin for Regulatory Network Enhancement CREB1 SNCAIP DRD1 DRD2 HSF1 HTRA2 GNAI1 PPIF PINK1 HEL-S-67p HNF4A CASP9 REST GNAL SDHA CYCS PMC6604468__F7 MUC17 inhibits the progression of human gastric cancer by limiting inflammatory responses MUC17 CDX1 RHO PMC5705614__F1 The core elements of the mammalian Hippo signaling pathway MAP4K2 MAP4K3 VGLL4 LATS1 CDC2 MOB1A MOBKL1A LATS2 HEL-S-31 MAP4K1 PMC5705614__F3 Schematic depicting the mechanical regulation of the mammalian Hippo signaling pathway AMOT ARHA RAC1 PMC5705614__F2 Schematic depicting the hormonal regulation of the mammalian Hippo signaling pathway AMOT APC ARHA RAC1 LPA PMC5705614__F4 Schematic depicting the metabolic regulation of the mammalian Hippo signaling pathway AMOT ARHA RAC1 PMC4467156__F12 New chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras FGFR1 GRB2 FGFR2 PMC7801429__F2 An ER signaling pathway network identified by IMPALA using Loi breast cancer gene expression data PLCG1 CHUK HEL-S-1 CSNK2A1 EGFR MAPK14 CREB1 WAS TOP2A INSR PRKCA BCR PTPN11 SRC HDAC2 MAPK1 JUN PRKCI SORBS3 TUBB FOS GMFB LMNA CRK IRS1 PS1TP5BP1 CASP3 TSC2 PTPRC YWHAQ ITGB4 CREBBP KHDRBS1 ERBB2 LCK LYN GRB2 PTPRE JAK1 HEL-S-93 SHC1 SOCS1 STAT3 PMC7385185__F11 The two-way communication between AMs and AECs in LPS-induced airway inflammation TLR4 IGF1 IL1B PMC7503879__F6 Insulin/FoxO signaling pathway in silkworm diapause eggs at onset of diapause IGF1 PDK2 INS PMC4939711__F1 Oncogenic signalling and nutrient availability influence cell metabolism MYC ACLY HIF1A HEL-S-133P FASN GLS PMC4213571__F2 Model depicting Tax-induced shuttling, localization and activation of canonical and noncanonical NFKB signaling pathways PDLIM2 CYLD RELB USP20 TRAF6 RNF4 MCL1 IL17RB OPTN PMC4939711__F3 Complex, compartmentalized pathways of NADPH production TIGAR MTHFD2L F2 SHMT1 MYC MTHFD1 HEL-S-51e MTHFD2 PMC8102819__F2 Immunopathology of Acute Kidney Injury in Severe Malaria VCAM1 IL13 TNF PMC4939711__F2 Catabolic pathways support metabolism during nutrient stress CS BRAF ACSS2 PMC4568025__F2 Interaction network for human CIBLIN transcriptional regulators NFE2 LBX1 AFF1 NRF1 GATAD1 CBFA2T2 ETV6 PFDN1 MSR1 MYC L3MBTL4 CREBL2 MNX1 ZNF146 POU6F2 RHD FOXC2 PPARGC1B SOX9 L3MBTL1 HES1 TCF15 HOXB2 GLIS1 MSL3 MNT GBX2 FOXL1 ESRRB FOSB TCF21 NKX3-1 TFAM RFX5 USF2 FOS HOXA2 SOX8 MED9 AEBP2 PLAGL1 MED16 NFKB2 YLPM1 MED28 RREB1 NFATC4 ZNF292 RELB PLAGL2 GLIS3 ESRRA GABPB1 GCM1 AFF4 MTF1 BACH2 MSC NKX3-2 MED1 MED30 MED25 ZNF488 MED24 NFAT5 NFATC1 NFE2L2 PHTF1 GSX1 ID1 NFATC3 ID3 IXL LMO4 NFATC2 MYCL NFKB1 NFE2L3 SOX10 MED26 NPAS2 PMC7394371__F3 Gene expression profile analysis of the rabbit retinal vein occlusion model INA COX2 BAD LTA CS DAO FRK MEN1 TRAF2 LAT ADK PMC3644335__F2 Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes ABCG8 ABCG5 LDLR NPC1L1 PMC10525124__F2 Oxidative Stress in Liver Pathophysiology and Disease KEAP1 DUOX1 DUOX2 NOX4 NOX5 PMC3941591__F5 ‘Ephrin Receptor Signaling’ was the second canonical IPA pathway induced in LR rats upon FST exposure GRB2 RAF1 SHC1 PMC5569090__F11 Schematic presentation of the mechanism for shell biomineralization mediated by the TGFB/BMP signaling pathway in molluscs BAMBI BMPR2 SMAD4 SMAD1 DKFZp781O1323 PMC3941591__F4 Top Ingenuity networks of genes whose expression was significantly altered in the hippocampus upon FST exposure REV1 PTMS RNF11 MGLL SMAD2 PACSIN1 RHO ZNF24 FAM118A RBBP8 LARP4B FEN1 RIPK1 NOG ITSN2 APLP1 ACTL6A PABPC1 LIN7A LDOC1 NEU3 RPS27A PC4 SOX2 NMB TUBB STXBP1 EEA1 STXBP5 CACNB3 RAB7A HOMER2 RAD17 RGMA OGG1 SMAD1 VAMP7 AGAP2 DKFZp781O1323 MSI2 PMC11772949__F3 The RLR adaptor MAVS mediated by protein palmitoylationIn the RLR signaling pathway, CPT1A interacts with ZDHHC4 to promote MAVS palmitoylation at Cys79 RIPK1 ZDHHC4 CPT1A RAC1 CASP8 MAVS ZDHHC24 ZDHHC7 PMC4133210__F1 Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells ATF4 EIF2A TRIB3 XBP1 PMC6972624__F10 Proposed model DAO MYC RBX1 PMC10758544__F9 Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NFKB signaling pathway CTSK NFATC1 MMP9 PMC3564018__F10 Stress-suppressed genes involved in antigen presentation and synapse formation TH CD58 CD14 CCR5 MHC2TA HEL-S-99n TNF IFNG TLR4 TAP2 HEL-S-269 CD2 CCR7 IL2 PMC10243851__F1 Clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis TSC2 TSC1 CD44 IRF3 LATS1 LATS2 RHEB PMC7477642__F2 Selected pathways relevant for plausible salvaging of residual ovarian function in primary ovarian insufficiency KIT AMH RAD51 PTEN MTOR PMC8771833__F4 Slit/Robo Signaling pathway in Bone Metabolism ROBO3 ROBO1 ROBO2 SLIT3 SLIT2 PMC3149740__F5 Mammals have two distinct but ultimately converging pathways to apoptosis BAD TRADD BIK BMF FADD HRK BAX BOK PMC2898443__F1 The eukaryotic 80 S initiation pathway ELF2 EIF5B ELF5 ELF3 EIF4H EIF4B EIF5 PMC8771833__F5 Slit/Robo Signaling pathway in Bone Metabolism ROBO3 ROBO1 RAC1 CDH2 SLIT2 CDC42 PMC7403683__F1 Conditional reprogramming (CR) culture system and the potential molecular mechanisms of CR GAB2 CD44 HBEGF RHO MTOR PMC7530640__F1 Role of microglia and canonical NLRP3 inflammasome in Alzheimer's disease NLRP3 HMGB1 IL1B GSDMD PMC6197541__F1 Associated cell signaling pathway and related potential therapeutic areas SMAD4 HIF1A PMC5293201__F1 Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective ALAS1 KEAP1 FTMT EGFR PMC8990295__F3 Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets GPX4 SLC7A11 SIRT6 HIF1A SIRT3 PMC7884075__F4 GWAS hits in the IGF-1 pathway SOCS2 IGF1R GHB2 RASA2 INS PTEN IGFALS THRA RAB3IL1 PI3 RIN2 GHR RAB26 RABEP2 INSL6 INS-IGF2 GHSR IGF2 PI15 IRS1 RAB3D IGF1 GH1 SH2B1 INSL4 SHC1 IGF2R STAT3 PMC8257068__F1 Prospect of CDK4/6 Inhibitors in Triple-Negative Breast Cancer TSC2 CDK2 DEDD CDK4 PTEN CDK6 RHEB PMC9468713__F7 Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IKBA–NFKB p65 Complex CTSK NFATC1 TRAF6 PMC5866851__F2 Visual description of the IL-31 and IL-33 cascades leading to the activation of the genes and the proteins involved in the development of inflammatory disorders CCL24 IL33 CCL17 CCL5 IRAK4 CXCL2 CCL2 MYD88 TNF OSMR CCL3 PMC7847103__F1 Subgroup specific actionable molecular pathway in MB SUFU SMAD2 APC GSK3B TGFBR2 SHH SMAD4 SMO PMC7547805__F2 Regulatory mechanisms of TEAD in cancer biology SOX2 MMP9 MYC TEAD4 IRF3 LATS1 AXL LATS2 IGFBP5 TCF4 PMC5557384__F5 Insulin-induced PI3K-Akt and MAPK network in hepatocytes BAD LARP1 FOXK1 AKT1S1 GYS1 EIF4E MTOR IRS1 RHEB TSC2 GYS2 TSC1 GRB2 ACLY GRB10 SOS1 SHC1 PMC10536768__F4 Innate Immune Response to Viral Vectors in Gene Therapy CGAS IRF7 TRAF3 IRF3 MYD88 IFNAR1 TLR3 PMC3590592__F6 Proposed schematic representation of Wnt5a/Beta-catenin signaling in keloid pathogenesis APC GSK3B PMC10536768__F3 Innate Immune Response to Viral Vectors in Gene Therapy TBK1 CGAS TLR9 IRF7 IRF3 MYD88 PMC10536768__F2 Innate Immune Response to Viral Vectors in Gene Therapy TBK1 CGAS TLR4 TLR9 IRF7 IRF3 MYD88 IFNAR1 PMC2195651__F1 Fas (death receptor) signaling pathway and its inhibition HRAS FADD PMC2531163__F3 Developmental signaling pathways SUFU APC MYC SMO PMC4919901__F2 Allergic Mechanisms of Eosinophilic Oesophagitis MBP APC TGFB1 PMC11772949__F8 Modulation of JAK-STAT signaling by palmitoylationIn the JAK-STAT signaling pathway, JAK1, JAK2, STAT1, STAT3, and STAT5A can be palmitoylated STAT2 ZDHHC4 GFAP CXCL10 GSK3B ZDHHC3 IFNAR1 ZDHHC12 ZDHHC7 STAT1 ZDHHC23 ZDHHC21 ZDHHC5 ZDHHC8 JAK1 STAT3 CD36 PMC3146606__F2 PARP function in base excision repair and consequences of PARP inhibition ATM RAD50 SSB RAD52 RAD51 PARG MRE11A BRCA1 PMC9448771__F8 Graphical abstract. NAT10 functions as a negative regulator of neutrophil pyroptosis and a protective factor in sepsis NLRP3 ULK1 NAT10 IRF3 PMC12092303__F2 Molecular targets and mechanisms of O-GlcNAcylation in the central nervous system TH SOX2 OGA AgRP OGT SHH ARHA MTOR STAT3 PMC3022188__F1 Rationale for dual treatment targeting the IGF-1R signaling pathway in RMS IGF1R MTOR IRS1 PMC11772949__F5 RLRs induced by protein palmitoylationNLRP3 palmitoylation is induced by ZDHHC7 but suppressed by ABHD17A at Cys126 SQSTM1 ZDHHC1 NOD2 ZDHHC12 ZDHHC7 NLRP3 ABHD17A NOD1 ABHD8 ZDHHC5 PPT1 FASN CD36 PMC9052535__F1 Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells RBPJ RUNX2 SMAD2 APC LRP5 SMAD4 LRP6 MAP3K7IP1 SOX9 SUFU GRB2 SMO SOX5 ACAN COL2A1 SOX6 SMAD1 SHC1 DKFZp781O1323 PMC11772949__F7 Pattern recognition receptor signaling by palmitoylation NLRP3 ZDHHC14 IL18 ZDHHC9 ZDHHC5 GSDMD ZDHHC7 PMC4605373__F4 Apoptosis response pathway IKBKG CHUK BAD TRADD MAP2K4 MYC TRAF3 CASP2 CDKN2A TNFSF6 DFFA MDM2 CASP9 JUN IRF2 BAX HELLS SET IRF7 IGF2 MAPK10 IRF3 TNF DIABLO BCL2L2 IKBKB CASP3 BIRC2 NFKBIB LTA BBC3 RELA TNFRSF21 CRADD TRAF2 FADD CYCS HRK CASP4 BOK PMC11772949__F6 Pattern recognition receptor signaling by palmitoylation CGAS NRAS ZDHHC9 MYD88 TNF ZDHHC7 ZDHHC20 NOD1 ZDHHC5 RAB27B MAVS CDC42 CD36 PMC12092303__F1 Main physiological functions of O-GlcNAc in the central nervous system SOX2 OGA OGT STAT3 PMC5733947__F4 miR-155-5p and miR-200a-3p greatly influence TLR4 signaling pathways TBK1 IKBKE IKBKG IFNA1 MAPK3 SMAD2 TICAM2 TRAF3 TRAF6 IRAK4 MYD88 CDK6 IFNA2 EZH2 HSD17B11 JUN IL1B FOS MAP2K2 IRF3 EED IKBKB EP300 MAP2K1 SPI1 NFKB1 RELA KIF20A MAP3K8 TIRAP PMC3364444__F1 N-BPs may modulate myeloma progression through their effects on the mevalonate pathway and directly on MM plasma cells, bone marrow cells and immune cells in the bone marrow IGF1 RHO TNF PMC5312381__F7 MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway CXCR4 ARHA ARHGAP5 PMC9502927__F1 Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes DES CERK PMC8658460__F10 Crosstalk between E-Cadherin/Beta-Catenin and NFKB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis MMP7 PMC10136030__F4 In the nucleus, TERT performs both canonical (elongates telomeric ends) and non-canonical functions (participates in the regulation of gene expression) ATM CCND1 ATR TERT BAX PMC10136030__F3 TERT is involved in major signaling pathways and participates in regulation of gene expression BAD TERT BAX PMC3686618__F6 Main signaling pathways supposed to be activated in MEC exposed to either E LTA TLR4 CXCL10 CCL20 CXCL8 IRF3 MYD88 PMC10136030__F2 Classification of BCL-2 family proteins and their role in the regulation of the internal pathway of apoptosis BAD BIK BMF HRK BAX BOK PMC10136030__F1 Structure and functions of telomeres ATM TPP1 ATR TERT PMC7436626__F1 Role of H2S in lung inflammation KEAP1 IL6 IL1B PMC8232755__F7 DLX Genes: Roles in Development and Cancer PMVK SP1 HMGCR PMC3003905__F5 Spontaneous-fusion-mediated cell reprograming is controlled by Beta-catenin levels in ESCs and not by their proliferation WNT3A PMC3744901__F9 Regulation of RB/E2F pathway EGF MDM2 CDK4 PTEN PMC4313578__F3 Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease TSC2 TSC1 IGF1 FOXO3A F3 DEPTOR FOXO1 RHEB MLST8 PMC6728578__F9 Key proteins involved in the DNA damage response (DDR) following DNA double-strand breaks (DSBs) ATM MDC1 RAD50 ATR H2AX MRE11A BRCA1 PMC8005589__F1 Rationale to target mechanistic target of rapamycin (mTOR) in renal cell carcinoma (RCC) TSC2 TSC1 VHL PTEN RHEB PMC3520048__F2 Summary of the role of the mammalian target of rapamycin (mTOR) signaling pathway in the development of tuberous sclerosis complex (TSC) and inhibition by mTOR inhibitors TSC2 EEF2K RICTOR TSC1 EIF4E EIF4B IRS1 RHEB PMC7704201__F1 In the insulin signalling pathway, insulin attaches to insulin receptors triggering its dimerization and the intracellular autophosphorylation of their tyrosine residues, which constitute an attachment for IRS proteins PI3 IRS1 PMC5064357__F6 Novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes DGKG PIP5K1A IRS1 PMC7704201__F3 Nrf2/Keap1/ARE pathway in T2DM MAF KEAP1 PMC5969374__F4 Disrupted signaling pathways in GCB-DLBCL TNFRSF14 S1PR2 GC MYC BTLA BCL2 ARHA EZH2 MTOR BCL6 PMC9103477__F1 Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma GNRHR MC2R CYP17A1 CYP21A2 STAR PMC6111036__F11 D5R mutation induces dilated cardiomyopathy that is related to oxidative stress PLN KEAP1 BAX PMC5969374__F5 Disrupted signaling pathways in ABC-DLBCL BTK CARD11 BCL10 BCR CD40 SYK MYD88 MTOR CD79A IRF4 BCL6 PMC3230300__F2 Mucins in the Pathogenesis of Breast Cancer: Implications in Diagnosis, Prognosis and Therapy EGF DAO ERBB2 EGFR BAX PMC3866868__F2 Nodal pathway activity in the determination of L–R asymmetry NODAL PITX2 LEFTY2 PMC5244336__F9 The mechanisms by which PRRSV infection upregulated miR-373 expression and miR-373 facilitated PRRSV replication STAT2 IRAK1 IRF9 IRAK2 IRAK4 SP1 IFNAR1 IRF-1 PMC8508344__F1 Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment STS CYP11A1 HSD3B2 HSD17B1 CYP17A1 PMC8775994__F3 Photic Entrainment of the Circadian System FOS JUN PER2 SIK1 PER1 PMC5346293__F2 Signal pathway integration that regulates Hsp90 expression STAT1 STRAP HSF1 STAT3 PMC7356240__F1 Macrophage migration inhibitory factor (MIF) mediates immune response crosstalk in dengue pathogenesis CXCR4 MMP9 CD44 IL8RB CD74 PMC7985549__F1 Several ligands on the cell surface stimulate the production of PIP3 (phosphatidylinositol trisphosphate) by PI3K APC EGFR GSK3B PTEN PMC6120164__F1 Network of “Target-Pathway” in osteosarcoma (OS) based on the collected data from – RRAGD SGPP1 IRAK1 EGFR EFNB2 TLK2 SERP1 IFT52 AGO1 PERP KDR NXPE3 SNTB2 MAST2 TEX2 SCD STK17A REEP3 RUFY2 SKI PFAS MMD MTCH2 NUP160 PARP1 ZNF264 TARP TNKS2 RAB10 CBX1 NUFIP2 DCP2 VAMP3 TWF1 AAG1 TYMS PTPN4 CCNJ MCL1 RORA LAMC1 DYRK2 PMC4928587__F5 Proposed model for the role of PALB2 in linking BRCA1 with BRCA2 and RAD51 in a pathway of HR PALB2 BRCA2 RAD51 BRCA1 PMC4001855__F1 Glycosylation of the nuclear pore OGA OGT PMC11946485__F1 PI3K signaling pathway inhibition and antitumor immune synergistic therapy strategy TH HEL-S-92n STAT3 FOXP3 PMC11993743__F9 The potential of the SA8-E6-12 antibody cocktail to modulate immune responses activated by S100A8 TLR4 S100A8 MYD88 BAX PMC8273570__F1 Three modes of IL-6R signaling and their associated intracellular pathways SOCS3 GRB2 SOS1 SOCS1 STAT3 PMC6163404__F1 Brief overview of canonical and non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) activation pathways RELA RELB TNF PMC9068921__F7 Mechanism graph of the regulatory role of circ_0000811 in cerebral ischemic vertigo STAT1 PMC8668291__F1 Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/Beta-Catenin Signaling Pathway: Review of Mechanisms and Prospects APC LRP5 LRP6 PMC11946485__F5 Development of PI3K inhibitors represents a promising strategy to enhance the efficacy of cancer vaccines through the modulation of immune responses BCR APC CCR7 CD80 IL4 PMC2887830__F2 Regulation of intracellular Stat3 signalling IL10 SOCS3 MMP9 FGF2 IL11 IL6 HIF1A COX2 MMP2 TWIST1 CCND1 CXCL12 STAT3 PMC11946485__F2 Regulatory role of PI3K signaling pathway in immune cell function BAD BCR BCL6 STAT3 BAX PMC11619421__F6 PPI network of associated pain-related genes enrichments in KEGG pathways and tissue expression PDE1B GRIP1 PDE4A GNA14 MYC OLIG2 PDPK1 RPS24 WNT4 CALB1 PICK1 TBR1 ROR2 CHRM2 SCN10A SST FOS ERBB3 EEF2 CNP RPN2 PIP5K1C FZD4 HTR4 FBXW11 ADCY3 BCAN RPN1 CACNA1I VAMP2 POU4F1 GRID2 CRH AVP VSX2 ADRA1A GNB5 GRIK5 WNT9A GRIN3B FZD1 FZD9 DRD5 CACNA1S GABRB3 GPC1 PDGFA BIN1 GDNF AXIN2 INPP4A INVS EGR1 SHANK1 FGF2 NTRK1 CAMK2G DVL1 LEF1 ADRA1D GNAS PMC9270260__F12 Novel antiproliferative PKCAlpha-Ras-ERK signaling axis in intestinal epithelial cells RASGRP3 GRB2 CCND1 SOS1 HRAS ID1 PMC5950532__F6 Protein-protein interaction analysis of HOXA13-related genes in the first four Kyoto Encyclopedia of Genes and Genomes pathways ROCK2 TWIST2 LOC51064 CAMK2D ARHGEF12 EGFR CD44 CAMK2G PEX11B RALB PTEN FZD1 NR1C1 PEX13 GNG12 PRKCA GNA11 HOXD10 PEX2 EVI1 KITLG GNAL PPARG EHHADH PMC8922271__F5 Organelle interfaces by ER‐resident E3s SEL1L ENDOD1 UBE2G2 RNF5 USP15 RNF170 UBE2J1 TMEM43 INSIG1 ERLIN1 TMEM33 TMED1 PMC11638664__F6 Schematic synthesis of data and hypothesis ATOH1 APC EGFR GPR49 PMC8491218__F3 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors MYB SNAI1 PAX2 CREB1 CDK6 FYN SIAE FOXL1 GC SHH CPNE6 MRGPRF FURIN PALM UTP20 CGB7 ABCC2 ABCB1 ZNF780A SLC4A9 TCF3 SLC26A2 HNF1A FZD4 SHC2 VEGFC TSC1 VAMP2 PRKCB CYP2C9 CDKN1A CCL20 BCL2 NRG3 COL17A1 GCM1 AHR CYP17A1 RUNX1 PMCH TNNI1 HSD17B2 DDR2 PS1TP5BP1 LEF1 ENPP2 IL3 ERBB2 LCK LYN BAG2 EPHA2 CSF1 SLC24A2 MEIS1 BCL2L1 SULT1E1 HEL-S-78p BMPR2 FGF10 TRIM68 AXL FZD10 PLG WASF1 RUVBL1 PIK3R3 FOXO1 GRB7 GNG3 RET GRM3 TP73 HEL113 SLC3A2 SLCO3A1 IGF1R RELB CACNA2D1 GCG INSR PLAT COL14A1 CYP2C19 FZD7 FFAR2 BAX LIF MMP9 PTGS2 WASF3 NTRK3 CXCL2 NRG1 PRKD2 PAX4 HMGA1 CYP3A4 NFKB1 TPD52 FSHR SOS1 PMC10380296__F7 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus BAD PTEN RAC1 IRS1 RXRA TSC2 PI3 BCR MDM2 SYK COIL RHOB BOLL CD19 PMC10380296__F6 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus EGF EPO CYC1 POR HEL-S-87p HEL-S-133P GLA PMC8491218__F1 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors ANK2 AGO2 GPC4 AFP RET TPM1 LCOR ABCC2 TTN PAX4 PMC10380296__F5 Significantly DEGs identified by KEGG in protein digestion and absorption pathways (ko04974) LAT2 CTRL NACA PMC2839260__F1 Schematic depiction of the signalling pathways stimulated by cholecystokinin (CCK) activation of the CCK1 receptor MAPKAPK2 CCK EGFR GRB2 SHE MAPKAPK3 EIF4E MTOR PMC7985550__F1 PI3K signaling pathway and related target drugs in endothelial cells FSHR MTOR PMC7072849__F9 Visual summary of the main findings of the study SOX2 LEFTY1 NODAL CER1 MIXL1 KRT18 SOX17 FOXJ1 FOXF1 FOXA2 FOXA1 TBX6 SHH GSC SOX5 CDH2 NOTO PMC6909953__F2 E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes CANX AMFR EBP ATF4 HEL-S-99n BCL2 VCP TRAF2 XBP1 PMC12052884__F1 Metformin in gynecological disorders: pathogenic insights and therapeutic implications TLR4 MTOR SIRT1 PMC7307862__F2 Various classes of lncRNAs TBX20 NKX2-5 TBX5 EZH2 EED PMC4117608__F6 Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health PIG59 ACTN1 TGFBR1 GSK3B POLR2H POR KATNB1 UQCRFS1 ARGLU1 MED15 POLR3E HPGD PGLYRP1 PTPN1 SMU1 CAD SSRP1 ABCB1 JUN SFT2D1 ATP6V0B VNN2 NDUFS6 BMP2 SNRPF HEL-S-162eP TUBA1A RPS13 LMAN2 HEL164 SRPK2 PSMD6 PSMD4 PMC4856760__F8 Working model of the regulation of the type I interferon and NFKB signaling pathway by TRIM9s TBK1 CGAS IRF3 MAVS PMC7985550__F3 PI3K signaling pathway and related target drugs in vascular smooth muscle cells IGF1 FOXO3A RUNX2 INS PTEN BMP4 PMC4473797__F1 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses CD14 IRF7 IRAK1 IRF3 IRAK4 MYD88 PMC5582844__F7 Proposed model depicting cross-talk between Gq-coupled GPCRs and CLEC-2 pathways TPR SYK PLCG2 DUSP3 PMC3334516__F4 TGFB signaling pathway members and potential pathway member LRG1 ROCK1 SMAD2 C6 ARHA MAPK1 RHO HMFT1766 PMC6820534__F6 Supposed mechanism CD47 FLNA GRPR FLNB CDC42 PMC3361678__F1 Many host factors are involved at each step of the HCV life cycle, which starts with virus binding to its specific receptors (CD81, CLDN1, OCLN, and SR-BI) DGAT1 VAPB VAPA EGFR EPHA2 OSBP GBF1 APOE CD81 PMC3158628__F1 Unlinking of the Golgi ribbon during G2 inhibits the recruitment and activation of Aur-A at the centrosome trough a novel mechanism PLK1 AJUBA CDC25B PMC6316730__F4 KEGG pathway analysis of the cell cycle in GNP-treated cells E2F4 SMAD2 APC SMAD4 STAG1 DBF4 CDK7 CDC45 STAG2 CDC20 CDC6 CDK2 MDM2 PCNA SKP2 MYT1 PMC11119800__F2 OGT is required for the development of infectious liver diseases OGA OGT MTOR PMC11119800__F1 Involvement of OGT in hepatic cellular stress ELF2 ULK1 OGT EIF2A RIPK3 MTOR MLKL PMC11119800__F4 OGT has dual effects on liver fibrosis TFF2 OGT PMC7076893__F8 Critical pathways of the potential Alpha-glucosidase inhibitors from RS INS PDPK1 RXRA INSR PMC4084917__F7 Fatostatin Displays High Anti-Tumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling MVD LDLR MVK HMGCS1 HMGCR FASN PMC11119800__F3 OGT contributes to the progression of NAFLD AIMP2 OGT PARP1 XBP1 SIRT1 FOXO1 FABP1 SIRT3 PMC9065265__F5 SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma SLC3A1 GCLM GPX4 GCLC SLC1A2 CD44 SLC3A2 PMC11119800__F5 Biological function of OGT in HCC KAT5 MMP14 AGER RUNX2 OGT MMP9 RIPK3 EIF4E MTOR RANBP2 FOXA2 PMC8827490__F1 Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens HEL-S-62p C9 C4B_2 FH CRP C7 C6 MASP2 CR1 PMC4473797__F6 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses IRF7 IRF3 TLR3 PMC4473797__F4 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses TLR4 IRAK1 TRAF3 TRAF6 IRF3 TNF TLR3 MAL PMC7019684__F2 mTORC1 is activated by amino acids, such as leucine, HMB, and arginine ULK1 CASTOR1 EIF4E BNIP3 FOXO1 PMC7827494__F2 Notch crosstalk with other signaling pathways HEY2 ECD LRP5 SMAD4 SHH LRP6 ARHA SMO CDH2 HIF1A HES1 PMC12040673__F6 Structural features and signaling pathway of RLRs STAT1 TLR4 TRAF6 IRF3 MYD88 TNF TLR3 TIRAP PMC12040673__F5 Inhibitory effects of supersulfides on the TLR signaling pathway NLRP3 TLR4 PMC12075957__F11 Canagliflozin alleviates progestin resistance by suppressing RARB/CRABP2 signaling in THRB knockout endometrial cancer cells RARB CRABP2 NR1A2 RXRA BAX PMC7321795__F3 Mechanisms of Selected circRNAs in CAD(A) circNfix leads to the degradation of Beta-catenin and inhibits cell proliferation through combining with miR-214 PINK1 CCNA2 YBX1 GSK3B MEIS1 CCNB1 DNMT3B ACR PMC8998738__F8 Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling HMGB1 C6 CDC2 BAX PMC3588051__F3 Ingenuity Pathway analysis of lung cancer and/or COPD versus controls revealed NFKB as a major foundation UBC HEL-S-26 HEL57 CRP HEL-S-15 HEL-75 EZR HEL-S-130P HEL-S-22 HEL-S-69p PMC3057579__F9 Hypothetical diaphragm of HS7 induced apoptosis and inhibition of Wnt/Beta-catenin signaling pathway in HT-29 colon cancer cells MMP7 TEF BAX PMC5591886__F2 A crosstalk between endoplasmic reticulum (ER) stress and p38 mitogen-activated protein kinase (p38 MAPK) pathway in the context of pemphigus FURIN PMC8922473__F6 Retinoic Acid-Induced 2 (RAI2) Is a Novel Antagonist of Wnt/Beta-Catenin Signaling Pathway and Potential Biomarker of Chemosensitivity in Colorectal Cancer CTBP2 APC GSK3B LRP5 LRP6 PMC4684888__F1 Interactions of oxidative stress, inflammation, insulin resistance, and hyperandrogenemia are described briefly in the figure, which are all involved in polycystic ovary syndrome physiopathology IL16 IGF1 SHBG IGFBP1 INSR PMC6861325__F4 Pathway analysis network of 131 preliminary potential genes EGF HGF CCL21 TGFBR2 TACR1 PTGER3 CALCR SLIT2 BMP4 PDGFD VAV3 CCL14 NGFR ACACB GHR LEPR CCL28 CMA1 NR1A2 SEMA3D PTGDR FGF7 KIT SEMA3A PDGFRA AREG FGF2 IGF2 NR3C1 FGFR3 S1PR1 ADRB2 NRG1 AVPR2 TSLP CTSG LEP EDNRB IGF1 OXTR PRLR SEMA3E IL20 BDNF MME MYLK SEMA3G AKT3 PMC8472484__F9 Ailanthoidol, a Neolignan, Suppresses TGFB1-Induced HepG2 Hepatoblastoma Cell Progression MMP2 CDH2 PMC7057934__F7 Schematic model of the underlying mechanisms of miR-126-3p-mediated suppression of proliferation, migration and invasion through the PI3K/PDK1/AKT pathway PLCG1 PAK1 BAD ROCK1 GSK3B CCND1 BAX PMC5789953__F1 Lipoic acid synthesis and scavenging in E LIPM LIPA LIPI PMC9649744__F4 New insights into the characteristics of DRAK2 and its role in apoptosis: From molecular mechanisms to clinically applied potential SMAD2 SMAD4 PMC7306856__F1 Autophagy pathway TBK1 ULK1 ATG16L1 ATG12 ATG3 ATG101 MTOR DKFZp686F0183 NBR1 WIPI2 STX17 ATG14 PPT1 PMC9063434__F2 Metallodrugs: an approach against invasion and metastasis in cancer treatment ME1 ZEB2 PMC8335161__F2 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer HEL-S-62p ULK1 ATG12 ATG3 ATG10 MTOR DEPTOR DKFZp686F0183 NBR1 MLST8 TTI1 C9 C7 C6 BCL2 ATG14 PMC8335161__F1 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer SIRT2 BAD BMF HTRA2 CASP3 ATM CASP9 TUG1 MCL1 ATR FADD HRK BAX PMC8335161__F3 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer EGF TNC LEF1 EGFR GSK3B LRP5 LRP6 PTEN EZH2 SOX4 PMC6361976__F1 The largest gene regulatory subnetworks in yeast CIRSR DKFZp686O2396 PMC3775241__F3 Regulation of hepatic hepcidin induction at the cellular level BMPR2 BMPER SMAD6 SMAD4 TMPRSS6 HFE IL6 TFR2 STAT3 PMC5382783__F5 Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics CS PTGES CYP2A6 PMC2919646__F2 Cystic Kidney Disease: the Role of Wnt Signaling BBS10 APC GSK3B VHL BBS1 ARHA RAC1 TSC2 DAAM1 TSC1 BBS4 TEF UNK BBS12 NPHP3 OFD1 PMC9482125__F11 CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells ATF1 SHH CCND1 ARHA SP1 PMC7298716__F9 DINO regulation in HPV-positive cervical cancer cells CDKN1A ATM MDM2 PMC1934518__F2 Ligands identified for EpCAM and possible functions related to them CD9 EPCAM PMC6361976__F2 The pertinent features of the phosphocholine pathways CDS1 PC PSD2 PMC4157394__F13 Apoptosis pathways affected by rocaglamides FADD BAX PMC10816399__F2 IL-6R interaction with gp130 for Stat3-mediated inflammatory target gene expression SOCS3 IGF1 SOCS1 STAT3 PMC4157394__F12 Inhibition of protein synthesis by rocaglamides TSC2 TSC1 GRB2 PTEN EIF4E MTOR RHEB PMC4085993__F4 Iron Homeostasis in Peripheral Nervous System, Still a Black Box? MPZ MBP NRG1 PMC3408425__F9 Systems-level regulation of metabolic genes by Met TFs HEL-S-26 CDS1 GPX1 ACO2 GUK1 MDH2 PMC6055003__F1 Notch pathway is regulated by short-range cell–cell signaling NOTCH2 NOTCH4 RBPJ DLL4 NOTCH1 DLL3 HIF1A NOTCH3 PMC8549964__F3 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model PIK3CD CCR5 CCR2 TNFRSF14 ROCK1 CSF3R NCF4 CCL7 CCL2 CSF2RB DKFZp686L0365 ITK TNFSF14 SRC ROCK2 STAT2 PF4 VAV1 ARHA RAC1 PS1TP5BP1 PIK3R5 IKBKB CXCR3 ACVR1B JAK3 IL11RA CSF1 INHBA NCF2 PMC5659022__F2 Proposed scheme for the role of BMSCs in modulation of p53-miRNA interaction in association with stroma-induced drug resistance in MM CDKN1A IL6 BAX PMC8549964__F2 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model ROCK2 PIK3CD PLCB2 PIK3R5 S1PR2 PRKCB ROCK1 S1PR1 BCL2 S1PR3 S1PR5 S1PR4 PMC2810618__F8 Signaling network model for heart valve development and remodeling ERBB2 NFATC1 ERBB3 EGFR HBEGF HAS2 PMC4006928__F1 DNA Damage Response, Redox Status and Hematopoiesis ATM BMI1 PTEN PMC3149098__F6 GProX Pathway Analysis of the Cellular Response to EGF Stimulation MCAM BTC MAFK PIR PMC8164969__F2 Molecular pathways governing hepcidin regulation in the liver ERFE BMP6 HAMP KEAP1 BMP2 TMPRSS6 HFE TERT TFR2 STAT3 PMC8164969__F1 Iron regulatory cycle ERFE HAMP TMPRSS6 HFE TFR2 PMC5455213__F1 Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature CD47 NONO PMC5360051__F5 Proposed deregulation of type I IFN signalling pathway by AFB1 STAT2 TYK2 JAK1 PMC5453167__F2 Protein-protein interaction network of the DEGs EFCAB6 MORC1 MCHR2 PTPN11 PSMD4 JUN PMC8393694__F2 Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates APOB HMGCR ACAT2 PMC4005604__F2 Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease VIT RHO MTOR IPP CDC42 PMC7405053__F1 An overview of PG biosynthesis, receptors, and downstream signalling pathways COX1 AKR1B1 PMC7405053__F3 Possible mechanisms for PGE2 modulation of immune cell functions in COVID‐19 STAT2 IRF7 IRF3 CCL2 MYD88 TNF IFNG STAT1 NLRP3 COX2 IL22 ACE2 IL1B TMPRSS2 STAT3 PMC5206770__F10 Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice TSC2 RICTOR TSC1 PDK2 RHO PTEN MTOR RHEB PMC2832675__F1 Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement CASP3 BCL2 TNF CASP8 FADD BAX PMC4259944__F1 Mutant epidermal growth factor receptor endocytic trafficking EGF ERBB2 EGFR SRC PMC7173364__F6 Apoptotic Cell Death Induced by Fractions F2 and F3 of Vitex Rotundifolia in T-47D Cell Line F2 F3 BAX PMC9164338__F5 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses NQO2 GCLM HEL-75 HMOX1 PMC5584748__F3 Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information CYP2B6 DHRS9 LRAT CYP2C9 CYP3A4 CYP2C18 CYP1A1 CYP2A6 CYP1A2 CYP3A7 PMC4675101__F8 Molecular pathway underlying interaction of Zn deficiency and miR-31 overexpression in promoting esophageal preneoplasia STK40 S100A8 S100A9 SP1 PMC533862__F1 Heuristic model showing the tyrosine phosphorylation signaling pathways in sperm cell involved in capacitation PMC3897565__F1 Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells IL10 PLCG1 IL2 PMC9164338__F7 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses STAT1 TNFSF6 IRF3 TYK2 PMC5289288__F1 Identification of KRT16 as a Target of an Autoantibody Response in Complex Regional Pain Syndrome HEL-S-30 TUBB GFAP F9 EEF1A1 SERPINB5 HSPD1 HEL-S-87p CREB3 PS1TP5BP1 HEL57 ANXA2 SERPINA1 TPSAB1 NFYA KRT10 KRT14 ENTPD1 PMC6102400__F1 Interactions of Lactobacillus rhamnosus GG or LRY (green) with Helicobacter pylori (red) and damaged epithelial cells at the gastric mucosal surface EGF COX1 MUC6 TNF PMC9336529__F2 Clinical potential of the Hippo-YAP pathway in bladder cancer MINDY1 LATS1 PMC5528331__F4 MAPK signalling pathway with unstable and stable (copy number and expression) genes represented PRKCZ MAPK9 PPP3CA MAP3K11 RASGRF2 FLNA ATF2 PPP3CC MAPK3 MYC MAPK14 TRAF6 GCK CRKL TAOK2 NF1 MAPK12 HEL-S-11 CASP9 MAPK1 MAPKAPK2 DUSP4 MAP3K1 SOS2 FOS MAPK7 MAPK10 MAP3K7 TNF HEL-S-31 TMEM37 MAPK13 DUSP10 PPP3R1 MAX GRB2 MAP3K14 PRKCH MEF2C DUSP7 TGFB1 AKT3 CDC42 FGF4 CASP6 EGF IKBKG BRAF MAP2K4 TGFBR2 PPP3R2 CASP2 MAP4K1 ATF4 MAP4K3 UNK JUN CD14 HSPB2 MOS NTRK1 MAP2K2 MAP3K13 MAP3K12 DDIT3 IKBKB CASP3 HEL-S-102 NLK NFKB1 RAF1 TRAF2 RASGRP4 PMC9336529__F1 Clinical potential of the Hippo-YAP pathway in bladder cancer NF2 LATS1 MOB1A MOBKL1A LATS2 PMC3285584__F9 Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway NODAL SMAD2 GLI3 FGF8 SHH FOXG1 PMC9336529__F3 Clinical potential of the Hippo-YAP pathway in bladder cancer MINDY1 ARHA RHOB CDC42 PMC3713848__F9 Proposed model for the integration of primary afferent, mast cell and sympathetic systems in supporting CRPS-related nociception NGF IL6 RAMP1 IL1B PMC4401766__F1 Simulation Predicts IGFBP2-HIF1A Interaction Drives Glioblastoma Growth VHL IGFBP2 HIF1A PMC4828118__F3 Drugs interfering with breast cancer (BC)- and obesity-related pathways TSC2 TSC1 HIF1A MTOR PMC5544725__F7 Role of 1,25(OH)2D3 in myofibroblast differentiation and extracellular matrix deposition in TGFB1-induced nasal polyp-derived fibroblasts and nasal ex vivo organ culture NR1i1 SMAD2 PMC2840262__F2 Autophagy and the Ubiquitin-Proteasome System in Cardiac Dysfunction BAG3 NBR1 BAG1 PMC7730964__F1A Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness PYGO2 APC GSK3B LRP5 LRP6 BCL9 PMC4934886__F4 Aortic valve stenosis–related biological processes CD133 L1CAM AGTR1 TNFRSF12A NRARP CCL5 LPA HSPD1 SOX9 CCR1 MMP7 KDR PLEK2 MMP2 CCR7 NOTCH1 GSC KCNN4 FURIN NOS2 APOE CST7 GPC5 CTSK PKHD1L1 ELOF1 BDKRB1 HBEGF TNF FXYD1 WNT3 HSPG2 TNFSF11 VCAM1 IL2RA CXCL12 TGFB1 CXCL1 CD248 COL3A1 PLEKHG1 ADAM12 TGFBR2 SAMD1 AGTR2 ADAM17 CADM2 CADM1 ANGPTL1 NR1B3 opn SFRP1 PECAM1 CHI3L1 IL2RB IL10 MGP RUNX1 BMP2 HLA-DOA CTSZ CTSG CXCR3 MGST1 STAT4 AHSG APOL6 SMPD1 JAK3 GPR158 CCL18 PPARG CTSS ANGPTL2 TNFAIP6 FGF8 APOC1 CADM3 TNFRSF11A PLOD2 DCN LRP1B HEL-S-2 COL12A1 TIMP3 FOSB ROR2 CCL19 MSX2 SERPINA1 ACAN CXCL14 LOXL2 RUNX3 FOS VCAN VEGFA ENG CTHRC1 HMGCR TNC APOB PLTP HEY2 TIMP1 TIMP4 IBSP BDKRB2 COL10A1 RUNX2 DKK2 ZBP1 CEACAM1 BMP4 AOX1 RARA CXCL16 GREM1 PLCE1 LDLR SELE CERCAM DKK3 MMP9 SMAD6 HIF3A TNFRSF11B WIF1 HEL-S-130P BGLAP ALPL ITGB7 TRHDE CCL23 MME PMC8268239__F5 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications AIMP2 DDC IL6 PMC8837098__F1 mTOR Signaling Components in Tumor Mechanobiology TSC2 TSC1 PTEN RHEB PMC11963613__F4 This schematic illustrates the role of Wnt/Beta-catenin signaling in tumor immune evasion and potential therapeutic strategies targeting this pathway CD47 APC BTLA TIGIT LAG3 PMC11963613__F3 This figure illustrates the toxicity and management strategies associated with Wnt-directed therapies in cancer treatment IMPACT APC PMC8268239__F1 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications GIG8 KYNU KMO AFMID ID1 PMC11963613__F1 This figure illustrates the role of the APC gene within the Wnt signaling pathway and its significance as a cancer biomarker APC LRP5 LRP6 PMC3256849__F6 A model for Kv1.3-mediated signaling pathway in human T effector memory cell differentiation SMAD2 CCNB1 SMAD4 CDC2 PMC6165247__F1 Consequences of endoplasmic reticulum stress response pathway ATF4 MTOR XBP1 RHEB PMC6288292__F2 Effect of different preconditioning stimuli in the MSCs response HGF CXCR4 MSC GDNF TGFA IL1B PMC3662029__F4 Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses ISG15 EIF4E IFNG PMC8197724__F1 P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases APAF1 FADD BAX BOK PMC6544365__F1 PI3K/Akt signal pathway is crucial to SDF1/CXCR-mediated homing of endothelial progenitor cells (EPCs) after myocardiac infarction VCAM1 CXCR4 PMC10088895__F1 PD-1/PD-L1 pathway plays a role in immunosuppression APC ZAP70 PTEN LAT PMC4498277__F2 Sclerostin actions LRP4 LRP5 LRP6 PTH PMC3137161__F1 Roles of shati on dopamine uptake – the relationship shati and TNFA SRI TNF PMC5644649__F3 Signaling model of Nef-mediated (A) apoptosis/anti-apoptosis, (B) down-regulation of expression of MHC class I molecules, and (C) down-regulation of the expression of CD4 molecules BAD LCK SYK PACS1 ARF6 ARF1 CDC42 PMC4599194__F1 Schematic model of MIF pathways in breast cancer cells (BCC) CXCR4 CD74 PMC8231548__F3 Perivascular Adipose Tissue-Derived Adiponectin in Vascular Homeostasis RS1 INS IRS1 APPL1 PMC9010822__F1 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances SUFU MYC SHH PMC11615816__F6 PGRN Inhibits B‐cell Activation and IgE Production through the PGRN‐IFITM3‐STAT1 Signaling Pathway IFITM2 GRN CD19 PMC9010822__F6 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances SOX2 SFN CD44 SHH BCL2 SMO ABCG2 TCTN3 MTOR PMC9010822__F3 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances PIK3CA TGFBI MAL PMC9010822__F2 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances SHH SMO STH PMC9010822__F5 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances DISP1 SHH SMO PMC9010822__F4 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances HHIP PTCH2 DISP1 TMEM107 HCFC1R1 GATA6 SUFU PTCH1 STK11 SHH SMO LZTFL1 TCTN3 TUSC3 PMC2955614__F5 Novel molecular regulation of Wnt/Beta-catenin pathway HDAC3 TNIK EGFR APC GSK3B VENTX HDAC1 FOXC1 SIAH1 GBX2 ZEB2 KLF4 STAT3 PMC8476931__F5 Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis MYB GPS1 ERF IPP PMC7838037__F5 NF-Kß mediated signaling pathway leading to mucus hypersecretion EGF MARCKS EGFR SP1 MUC2 PMC7838037__F4 MAPK mediated signaling pathway induced by interleukins leading to mucus hypersecretion MUC1 MARCKS IL16 MUC4 MUC5AC GRB2 MYD88 MUC5B MUC2 PMC4488716__F1 Signaling pathways of the endoplasmic reticulum (ER) stress response ATF4 EIF2A XBP1 PMC4517435__F1 Core components of the insulin signaling pathway MAP2 SOS2 MAPK3 NRAS PTEN GYS1 HRAS IRS1 PDPK1 SHC2 GYS2 MAP2K1 PTPN1 GRB2 MAPK1 RAF1 SOS1 SHC1 AKT3 PMC8832963__F3 Emerging role of long noncoding RNA RMRP in cancer development and targeted therapy YAP1 ANXA2 MDM2 SNRPA1 CCND2 PMC9559463__F3 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives SUFU PTCH1 SMO PMC9559463__F5 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives SUFU APC PTCH1 SMO LAG3 TNF IFNG PMC7926472__F1 A general map of core metabolism FES PMC3392647__F3 Metabolic regulation of epigenetics OGT SIRT6 SIRT1 PMC3875828__F1 Asp and aromatic amino acid biosynthetic pathways in plants ASPG PPY CBL PMC7350257__F2 PI3K-AKT-mTOR and RAS/MAPK pathway crosstalk can contribute to mTORC1 and AKT inhibitor resistance ULK1 BAD ERBB2 GSK3B MDM2 IRS1 SGK1 PMC7019732__F6 FIPV nsp5-mediated inhibition of the type I IFN signaling pathway during FIPV infection TBK1 TRAF5 TRAF6 IRF3 TRAF2 MAVS PMC7350257__F4 PI3K-AKT-mTOR and WNT signaling crosstalk EGFR APC GSK3B LRP5 MYC LRP6 PTEN LATS1 DEPTOR LATS2 SOX4 TSC2 TTI1 CDK4 HEL-S-133P PMC7350257__F3 PI3K-AKT-mTOR and AR signaling crosstalk facilitates resistance to androgen/AR and AKT-directed monotherapy KLK3 FKBP5 CYP17A1 PMC9559463__F1 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives SUFU PTCH1 SMO PMC11302957__F1 Core components of the Hippo pathway in mammals YAP1 AREG LATS1 AXL PMC11302957__F3 Crosstalk of Hippo signal pathway with other signaling pathways to regulate YAP1 HGF YAP1 EGFR FZD2 LATS1 RDH5 MTOR SIX4 PDCD10 PMC4868686__F6 VE-cadherin cleavage by ovarian cancer microparticles induces Beta-catenin phosphorylation in endothelial cells MMP7 PAK1 LEF1 MMP2 APC MMP9 LRP5 CCND1 RAC1 PMC6998390__F8 BACE2‐regulated pathway in glioma cells SMAD2 BACE2 PMC4521049__F8 New working model TLR4 EBI3 VCAM1 PMC428488__F1 Outline of the Taxol biosynthetic pathway C9 IPP PMC2992289__F5 KLA increases mRNA expression of genes involved in sphingolipid biosynthesis ASAH2 SMPD2 CERS3 LASS1 CERK SPHK2 CERS2 CERS6 PMC3073335__F2 RNA helicases of the RIG-I-like receptor (RLR) family play a crucial role in the innate antiviral response STAT2 IRF7 IRF9 IRF3 PMC10846991__F3 Interleukin-6 (IL-6) signaling pathway SHC2 MTOR STAT3 PMC7367493__F2 RNA sensing and regulatory roles of NLRs ATG16L1 ATG12 NLRP12 NLRX1 NLRP6 IRF3 DHX15 TRIM25 NOD2 DKFZp686F0183 NLRP9 GSDMD RNF125 TUFM NLRP3 NLRP14 IL1B MAVS PMC7367493__F1 TLR and RLR signaling pathways TBK1 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 IFNAR2 MYD88 IFNAR1 TRIM25 TLR3 TRIM65 TLR8 RIPK1 TLR7 ZCCHC3 JAK1 MAVS PMC10846991__F4 Overall signaling pathways between podocytes and glomerular endothelial cells (GECs) ANGPT2 ANGPT1 CXCR4 VEGFA CXCL12 PMC11799769__F4 Correlation network diagram between renal‐secreted proteins and proteins on the most significantly altered KEGG pathways in skeletal muscle NDUFV2 NDUFA7 LHPP LIF HEL-S-134P LAMB2 ORM1 MDH2 DAG1 NDUFA5 MAPK12 LAMB1 HP opn SUCLG1 NDUFB6 LAMA5 CYCS COA7 PMC5635761__F1 Possible Nucleic acid sensors participation in HBV pattern sensing in the life cycle of HBV TLR8 CGAS TLR7 TLR9 IRF7 DDX41 IRF3 MYD88 AIM2 TLR3 MAVS IFI16 PMC7790818__F3 Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore BCL2 BAX PMC7047768__F1 Summary of transcriptional regulation of senescence in MSCs CDK2 MSC CDK4 H2AX CDK6 PMC11232665__F4 Metformin likely acts on intervertebral disc degeneration through SIRT-related signalling pathways PINK1 SIRT1 SIRT3 PMC3789782__F1 Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling RAD17 TOPBP1 ATRIP ATR PMC11232665__F3 Mechanism of metformin in intervertebral disc degeneration HMGB1 CGAS MSC SNAP29 PMC6438438__F8 Diagram demonstrating the unfolded protein response pathway and downstream chaperone proteins ATF4 EIF2A XBP1 PMC11232665__F2 Intervertebral disc degeneration MMP3 ATF3 MTOR IRS1 SIRT3 PMC6711852__F2 Physiological and pathological hypertrophy CITED4 EYA2 FOXO3A PTEN MTOR ADRBK1 GATA4 BAX PMC10189743__F5 Involvement of ITGA and ITGB receptors in ‘focal adhesion’ and ‘ECM receptor interaction’ from the Kyoto Encyclopaedia of Genes and Genomes pathway database VASP BAD HEL-S-28 SHE ARHA PTEN CRK CDC42 PMC6181582__F3 Protein based pathway mapping of the patient response in the serum to antibiotic treatment TH APOB HRG PLTP ND1 PROC POR APOH HPSE SPIC APOA2 APOE PMC3163839__F3 Progression of amyloidogenesis in parahippocampal region and hippocampal formation of mediotemporal lobe HEL-S-11 CA3 SIRT1 PMC3163839__F2 Sirt1 activity as it relates to AD etiology RARB FOXO3A ADAM10 SIRT1 PMC3697894__F1 Notch signaling pathway EGF DLL4 DLL3 PSENEN PMC8353789__F1 Perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed? TFEB ATG101 MTOR ATG14 PMC12170998__F2 Development of Traditional Chinese Medicine in combination with EGFR Inhibitors against Cancer EGFR PTEN MTOR PMC12170998__F3 Molecular pathways related to EGFR-TKI resistance IGF1R EGFR PTEN MTOR AXL PMC7074480__F1 Mechanism of action of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome NLRP3 IL16 GSDMD PMC8631411__F2 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease NLRP3 AIM2 GSDMD PMC8631411__F1 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease ATG12 TRADD AMBRA1 UVRAG TRAF2 FADD PMC4037387__F2 JAK/STAT pathway dysregulation in tumors: A Drosophila perspective PRC1 CSK SCRIB PMC3203219__F1 Costimulatory pathways relevant in transplantation TNLG8A APC BTLA CD40 ICOS PMC4180975__F8 Model depicting CtsZ regulation of the protumorigenic functions of TAMs and cancer cells SRC CTSZ PMC4060956__F1 Abnormal Ca2+signaling in SNc DA neurons may cause mitochondrial oxidant stress, proteostasis deficits and eventual cell death PINK1 LRRK2 NACA PMC10376991__F8 An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis KEAP1 DGKE PMC3359066__F5 Identification of Functional Differences in Metabolic Networks Using Comparative Genomics and Constraint-Based Models ME2 MAL PMC7465596__F1 Signaling and gene regulation of the canonical cell autonomous unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC6682706__F1 Natural plant compounds and epithelial-to-mesenchymal transition TH HGF HEL-S-28 SMAD2 GSK3B BMP7 ARHA LPA MTOR MMP3 NEDD9 CDH2 SMAD1 TGFB1 DKFZp781O1323 TGFBI STAT3 PMC12142240__F7 Proposed pathway by which reduced SPDL1 expression leads to epithelial-mesenchymal transition and promotes cell migration and invasion in colorectal cancer EGF EGFR SPDL1 PMC11562816__F1 Low-frequency variants in genes involved in glutamic acid metabolism and Gamma-glutamyl cycle and risk of coronary artery disease in type 2 diabetes GAD2 PIG59 GCLM GOT2 OPLAH GCLC HEL-S-64p ALDH18A1 GGCT GAD1 DPEP2 GLS PMC4160336__F4 Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host NOD1 RHO CDC42 PMC4647833__F3 Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing SRI AGK MYL2 KLF10 TPM3 FOXK1 TNNC1 MYL3 DES TTN RYR2 MRPL3 ANKRD1 MYL12A HEL114 MYOZ2 TPMT GLA MYPN LAMP2 JPH2 ACTN2 FXN ADRB2 SLC25A4 PLN MYLK2 MYOM1 MYBPC3 PRKAG2 CASQ2 RAF1 CSRP3 PMC10844198__F2 Putative NFKB signaling pathway data mined from Euprymna scolopes reference transcriptome and genome TBK1 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TRAF2 NLRC3 TRAF4 TAB3 PMC4041713__F4 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis BTRC APC PRKX SMAD4 ARHA CXXC4 PRKCA NLK PLCB4 SIAH1 NFATC2 EP300 PSEN1 FZD7 VANGL1 PPP2R2A PRICKLE2 PMC4041713__F2 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis GDF6 SMAD2 LEFTY2 MAPK3 TGFBR2 E2F5 SMAD4 SMURF1 IFNG BMPR2 BMPR1A THBS1 ZFYVE16 SP1 RBL2 PMC4044302__F1 Sites of thyroid hormone regulation of metabolism UCP1 FOXO3A TRH LDLR CYP7A1 STAT3 MAFA PMC4290816__F1 Primary points at which PUFA-based supplements enter the PUFA biosynthetic pathway FADS2 ELOVL2 GLA PMC3641131__F6 Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains Beta-Cell Phenotype in Human Islets TSC2 TSC1 IGF1 MPC1 MPC2 MTOR IRS1 PMC7069221__F1 Estrogen biosynthesis and signaling pathways CYP1B1 CYP1A1 PMC7990371__F3 Directly and indirectly anti-cancer pathways of APN TSC2 USP2 GSK3A CCND1 MTOR WIF1 STAT3 PMC9314982__F3 Coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy VLDLR TF PMC7069588__F4 Schematic diagram CDH2 PMC5913878__F2 Emerging roles of epithelial-mesenchymal transition in hematological malignancies TWIST2 TWIST1 BCL6 PMC152295__F1 The PI metabolic pathway and wortmannin sensitivity PI3 PTEN IPP PMC8256442__F4 Signaling Pathways That Regulate the Crustacean Molting Gland EGF EGFR MTOR RHEB INSR PMC8038686__F3 Tissue fragmentation and mechanical manipulation disrupt ovarian Hippo signaling pathway and promote follicle growth LATS1 LATS2 PMC120783__F7 GPI biosynthetic pathways in T PLG LPL GAL HEL-S-5 PMC4334750__F6 Theoretical model for metabolism of alcohol in the brain GRINA GPT2 GRIP2 GLUD1 PMC3523810__F7 Possible inflammatory signaling pathway that results from the functional associations of the identified inflammation-related proteins (marked with an underline), which is regulated by acupuncture in asthma S100A8 RHO S100A9 PMC9170579__F6 Long noncoding RNAs (lncRNAs) in human lymphomas ERG EZH2 SUZ12 EED PMC8783605__F3 Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention CRH NTS TNF IL1B PMC9600404__F3 Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision PTEN MTOR FGFR2 PMC6030085__F7 SOX17-mediated disruption of Wnt/beta-catenin signaling GSK3B SOX17 PMC3346964__F1 Four major molecular pathways activated by tyrosine kinase receptor B (TrkB) and IGF-1 receptor (IGF-1R) IGF1R IGF1 GRB2 RAF1 MTOR BDNF PMC5071175__F4 Planar cell polarity (PCP) proteins and spermatogenesis DAAM1 ARHA ROR2 RAC1 CDC42 PMC9189173__F7 Study on plasma amino acids and piperonamide as potential diagnostic biomarkers of non-small cell lung cancer PSAT1 HEL-S-51e PMC3918721__F1 TGFB signaling and MMPs interplay LTB SHE RHO PMC4260876__F7 Drought Tolerance Conferred to Sugarcane by Association with Gluconacetobacter diazotrophicus: A Transcriptomic View of Hormone Pathways MYB ERF EBF2 PMC6834079__F1 The Hedgehog signaling pathway and depiction of key regulatory interfaces HHIP BOC KIF7 SUFU PTCH1 SMO PMC7314846__F3 N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury CDKN1A LIF GSK3B CCND1 FADD STAT3 PMC11656820__F2 Expression of Tim-3 on various immune cells and the functional alteration of these cells in sepsis-induced immunosuppression IL10 HMGB1 CD44 TNF FOXP3 PMC3124359__F1 Estrogenic effects on gp130 signaling LIF BDNF OSM STAT3 PMC11656820__F1 Tim-3 signaling pathway HMGB1 FYN LCK ZAP70 PMC11656820__F3 Function of dysregulated Tim-3 pathway in sepsis-induced immunosuppression IL10 TH IL15 IL4 FOXP3 PMC3936888__F7 Scheme for illustrating the effect of Naproxen on the regulation of cell cycle and apoptosis mediated through the inhibition of the PI3-K signaling pathway BCL2 CDK4 MTOR BAX PMC3033145__F2 Anticoagulant properties of endothelial cells PC TFPI APC TF PMC9541200__F2 NAD+ deficiency in human congenital malformations and miscarriage: A new model of pleiotropy SIRT2 ART3 NMNAT3 ART4 PARP6 PARP4 NMRK1 SIRT3 HAAO HEL-S-90n KYNU NMNAT1 SIRT4 KMO SIRT5 SIRT6 NMNAT2 BST1 NADSYN1 NAMPT PARP1 TRPT1 TDO2 PARP3 NAPRT IDO1 SIRT7 NMRK2 PARP2 AFMID SIRT1 PNP PMC4568949__F5 Non-invasive prognostic protein biomarker signatures associated with colorectal cancer HLA-A CADM1 CFH F5 MRC2 VTN PIGR HMFT1766 CP PMC7993397__F1 Integration of mechanical- and ECM-based tumor microenvironment-imposed signals FYN PIEZO2 AMOT NF2 HEL-S-28 CD44 ARHA LATS1 LATS2 GRB7 PMC3128083__F9 RIG-I Mediates Innate Immune Response in Mouse Neurons Following Japanese Encephalitis Virus Infection TRAF6 RIGI TRAF2 FADD PMC9170579__F5 Long noncoding RNAs (lncRNAs) in human lymphomas BRAF CDK2 APC GSK3B CDK4 MTOR FADD CDK6 PMC4687703__F2 Local inhibition of miR‐24 in ECs would turn off apoptosis signalling pathway and improves reparative angiogenesis in post‐ischaemic conditions ESM1 PAK4 SIRT1 PMC6266414__F3 Glutamine inter-tissue metabolic flux starting in skeletal muscle, liver, and gut continues in the immune cells PDC PC HEL-75 SIRT1 GLS PMC4619950__F3 Main molecular pathways activated for the production of inflammatory cytokines STAT1 EPO HGF STAT3 PMC6352376__F4 Functional analysis of significantly changed proteins (SCPs) NUDT12 ABHD12 ATP1B1 CDH16 UMOD TMEM176A SLC25A11 ZNF183 HEL-S-78p NDUFS1 NDUFB8 GC ACSL1 COL6A1 NDUFA9 NDUFA11 RPS27 OGDH TPP1 UGGT1 FGA Nbla10236 ACAD10 HEL70 PLG PSMA4 MYO7B SFRS5 TMEM65 SPCS3 NDUFC2 APOOL EDEM1 NDUFB7 NPLOC4 SLC12A3 SGPL1 PZP HEL113 ITGAV ACTG1 MYH9 TMED9 TUBA4A S100A10 ACTN1 ANXA3 COG7 MYL6 DHX15 ANXA6 SFRS3 SERPINC1 NDUFA5 HEL-S-108 ACAT1 MYL12A NDUFB10 RPS6 ATP6V1A ACTN4 SEC61A1 TMEM176B COX7A1 MGAM NDUFV2 M6PR FTH1 LAMP2 NDUFS3 FAAH CHCHD3 COXFA4 HEL-S-130P HEL-S-102 NDUFA2 ERAP1 TWF1 COQ9 PRODH NDUFA10 SRSF7 RAN SERPINF2 LRPAP1 MME ACADM COL4A2 TGFBI PMC3319470__F1 Coenzyme Q10biosynthetic pathway and electron transport role in the mitochondrial respiratory chain ND4L CYB ND6 COQ4 COQ3 ND3 ND1 ND2 COQ9 COQ6 COQ5 ND5 ND4 PDSS1 COQ7 PMC4619950__F4 Molecular pathways activated by inflammatory cytokines and growth factors and affected by MPN-associated mutations STAT1 EPO TPO JAK1 MPL STAT3 PMC9189280__F7 Curcumin Blocks High Glucose-Induced Podocyte Injury via RIPK3-Dependent Pathway RIPK1 RIPK3 MLKL PMC6058053__F3 Altered B cell receptor (BCR) and co-receptor signaling promotes increased autoreactivity within the naive B cell repertoire BCR CD40 WAS PTPN22 PMC7124275__F9 MAPK7-CEBPB signaling cascade negative regulation of mir128-3p under ischemia/hypoxic condition MAPK7 CREB1 IRS1 PMC6558065__F1 Proposed MFG-E8 signaling in radial glial cells (RGL) via AvB3/PI3K/Akt/mTOR pathway MTOR CCND2 PMC3037521__F2 Selective elimination of messenger RNA underlies the mitosis–meiosis switch in fission yeast TSC2 TSC1 TF PER1 PMC6156430__F2 Schematic diagram of the molecular mechanisms underlying K63‐linked polyubiquitination and cardiac hypertrophy TRADD TRAF6 TRAF2 TAB3 PMC7201019__F5 Pathways of viral sensing and TLR signaling, metabolism, cell motility and protein export are enriched in the NK RMtsig CLTA CTSS FOS FLNA ARHA PTEN HEL-S-87p MTOR TG NAPA GUSB MDH2 PC UROD UROS RELA LYN RETSAT ACAN JUN IDUA ADK CCS PMC3587307__F1 LEM2 is a negative regulator of ERK signaling during muscle differentiation EGF MTOR PMC4890029__F9 MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells CCNB1 PMC4818947__F7 Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents ATM ATR PMC6765066__F13 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases HMGB1 TLR4 TLR9 MPO MMP9 CXCL8 IL6 IL1B SIRT1 PMC9221142__F2 Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance? HTT EGFR SRC PMC6765066__F12 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases HMGB1 TLR4 MPO MMP9 CXCL8 PMC2629979__F1 Molecular Mechanisms in COPD pathogenesis and potential therapeutic targets EGR1 KEAP1 TGFB1 TGFBI PMC8586819__F2 T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective CD160 CD244 CTLA4 TIGIT TOX TNF IFNG PMC4495583__F3 Dendritic cell metabolism TBK1 NLRP3 TLR4 IRF7 TRAF6 IRF3 ECSIT TLR1 IL1B MAVS PMC12058309__F1 Biosynthesis, metabolism and signaling of SA NPR3 SAG COCH PMC4495583__F2 Dendritic cell metabolism TBK1 XBP1 HK2 PMC5460804__F7 Schematic drawing that illustrates the likely signaling pathway by which laminin A2 at the basement membrane regulates Sertoli cell BTB dynamics in the seminiferous epithelium of rat testes RPS6 PMC4937469__F11 Surviving problems during chromosome replication RAD51 DBF4 RAD18 PCNA PMC8166896__F1 Molecular mechanism of necroptosis TRADD GSK3B RIPK3 CDC37 TNF PPM1B AURKA TLR3 ZBP1 RIPK1 CYLD OGT SHARPIN TRAF2 OTULIN FADD MLKL MIB2 PMC8130833__F1 Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma ATM ATR PMC6544733__F5 Bioenergetic metabolites differ significantly between the Boxers and Chihuahuas HEL-S-62p C6 PMC3458056__F5 Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas NFKBIB CBX3 PRMT2 RELA MAPK3 MYC MAPK1 IL6 TNF CSNK2B IGFBP5 TERT PMC3695482__F2 Focus on Histone variant H2AX: to be or not to be PALB2 ATM BRCA2 RAD50 H2AX MRE11A BRCA1 PMC11884491__F7 Schematic illustrates the antiproliferative effect of P SMAD2 PCNA PMC8000126__F7 TR-dependent regulation of genes in the Wnt signaling pathway, a representative pathway likely involved in the development of adult intestinal stem cells, as revealed by RNA-seq analysis BAMBI INVS APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA RBX1 NLK DAAM1 SIAH1 PMC5446740__F5 Disease module predicted by GLADIATOR for hyperinsulinism PDX1 LIPC PLK1 HEL-S-99n INS IGFBP7 NR2F1 HLA-DQB1 CEBPA RB1 NR1C1 UBE2Z INSR APOB IGF1 HNF4A ARPC3 PSEN1 LPL SP1 SP3 HLA-DQA2 PMC12219554__F1 Schematic illustration SOST STAT3 PMC7043073__F3 Impact of co-mutations on the microenvironment of KRAS-mutant lung adenocarcinoma KEAP1 MYC PMC4991528__F3 Recommended decision pathway for UK patients considered for treatment with tolvaptan according to Renal Association guidance based on the NICE decision FH EGFR PMC3706840__F8 PRL-Dependent Tyrosyl Phosphorylated PAK1 and 3D Collagen IV Regulate MMP-1 and MMP-3 Production and Invasion via MAPK Pathways Schematic representation of the proposed working model MMP3 PAK1 MMP2 PMC9418002__F2 BCL-2 family proteins BAD FOXO4 FOXO3A CXCR5 IL6 EIF4E MYD88 BMF BCL6 BTK BCL2A1 BCR CXCR4 PMAIP1 BCL2 CD40 SYK IL4 BAX PMC3725503__F1 Network of the mechanistic Target of Rapamycin (mTOR) signaling pathway RS1 TSC2 TSC1 KLF2 RHEB PMC5145311__F2 NLRP3, NLRC5, NLRP7, AIM2 and other inflammasome-like signaling is activated in response to S NLRP3 LTA AIM2 NLRP7 PMC3001303__F1 mTOR signalling pathway TSC2 RICTOR PTEN MTOR IRS1 RHEB MLST8 PMC7033713__F2 Summary of the effects of FGF19 signaling in specific cell types NPY AgRP FGF19 PMC5869511__F1 Antiviral innate immune pathways in dipteran insects AGO2 XRN1 MYD88 CSA2 PMC3006043__F3 Colorectal Cancer Molecular Biology Moves Into Clinical Practice BRAF EGFR GRB2 PIK3CA PTEN PMC9237101__F7 Model depicts the role of the IDO1-MDM2-p53 pathway in DLBCL growth IDO1 MDM2 BAX PMC7565746__F4 Diagrammatic representation of significantly differentially expressed genes associated with the fatty acid biosynthesis pathways, glycolysis, pentose phosphate pathway and TCA cycle when Schizochytrium was cultured under low-temperature conditions PC PMC6090926__F1 Molecular interactions between LRRK2, aSyn and p38 MAPK in the regulation of apoptosis and autophagy LRRK2 RAC1 MTOR CDC42 BAX PMC4277436__F1 IL-33/ST2 pathway: therapeutic target and novel biomarker IL33 TRAF6 MYD88 MAL PMC4682238__F1 Schematic representation of Slit-Robo signaling pathway in gastric tumorigenesisᅟ SRGAP1 CCND1 ROBO1 DKK1 SLIT2 MTOR PMC8820467__F2 Canonical Wnt/Beta-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering IHH RUNX3 RUNX2 APC LRP5 LRP6 SMO DKK1 EZH2 SMAD1 DOT1L DKFZp781O1323 PMC3427704__F1 AID-associated gene network EXOSC8 IRF8 EXOSC3 EXOSC1 UNG KPNA1 DIS3 EXOSC6 BCL6 GIG8 PAX5 EXOSC5 MSC MDM2 YY1 CD40LG IL17C PRKDC EXOSC4 IRF4 SUPT5H PMC3645661__F1 An overview of signaling by the EGF family (with EGF and EGFR/ErbB1 as example) from cell surface down to the nucleus (without taking into account endocytic trafficking and recycling of the receptor) EGF LRIG1 SOCS4 EGFR GRB2 PTEN MTOR TF CBL PMC4633896__F6 Mechanistic model for irradiation-dependent and GSK3Beta-related signaling in HNSCC cells: Activated and inactivated molecules are displayed in green and in red, respectively RICTOR GSK3B EIF4E MTOR PMC355855__F10 Models for repression of TGFB signaling by the Smurf-Smad7 complex and reactivation of TGFB signaling by the Jab1/CSN5-Smad7 complex SMAD2 SMURF2 SMURF1 PMC4779708__F1 Schematic model of signaling pathways implicated in tumor cell vascular mimicry (VM) NOTCH4 MMP14 SOX2 NODAL TWIST1 SMAD2 CD44 SRC EPHA2 TF PMC7232496__F7 Postulated mechanism of disease resistance in cattle to PPRV—Schematic representation of roles of differentially expressed genes ISG15 IFIT3 IFIT2 TLR7 IRF7 IRF9 IRF3 PDE12 TLR3 IFI6 IFIT1 PMC4425062__F6 Theoretical model of the negative regulation of the PA signal pathway by myostatin in skeletal muscle PLCD4 MSTN MTOR PMC7559280__F3 Epigenetic modifications in the livers of male young adult IUGR-N mice FZD3 CSNK2A2 TDG F9 SMAD2 ALB GNG7 RB1 RDX UBE2J1 BCR KHSRP FRS2 NCKAP1 FURIN TDP1 ALDOB ZNRF3 TCF3 LRP5 EIF4E RAB6B UBE2E3 ZBTB18 ARID1A AEBP2 UNC5A ARHGEF28 ARHG TDRD5 WTIP PLXNA4 GABBR2 CNIH3 TWIST1 ACVR1B SIAH2 IGF2R GNB4 FOXJ3 MAP2K4 PCK1 TNK2 LNX1 LATS2 RAB15 RYBP GNAZ PM20D2 HECW2 EVL RAC1 GAB2 NFIL3 TRIM28 SEMA6B WNT5B VEGFB DOCK7 PMC11983340__F1 Engineered metabolic pathway for the biosynthesis of disubstituted MAAs CYC1 HEL107 tal-1 PMC3676795__F2 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis BAD BNIP3L PTEN FADD BAX PMC6338478__F8 IGF-IR is now considered a functional RTK/GPCR hybrid, integrating canonical tyrosine kinase and GPCR signaling IRS4 MDM2 IRS1 PMC2593006__F3 Signalling pathways underlying neuronal survival and cognitive performance ARC MTOR BDNF PMC10377641__F3 Leptin: A Heavyweight Player in Obesity-Related Cancers TF STAT3 PMC8533426__F5 LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis FST HEL-S-62p PLAT ANGPTL2 PLG CFH IGFBP1 COL1A1 TGFB1 PMC3731316__F1 Gene Network Analysis of Candidate Loci for Human Anorectal Malformations INTU CTNNA1 SIL1 DKK4 WDPCP SOX4 CDH18 DESI2 WNT4 EAF1 AMOTL1 SOX6 ELL PROK1 PMC2810084__F7 TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice TLR4 APC MYD88 PMC11651285__F1 First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives EGFR GRB2 MTOR PMC8934501__SF1 GSK-3B suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis RUNX2 SMO PMC5595801__F2 Regulation and interaction network model of 17 cytokines IL10 IL1A IL3 IL9 IL13 IL2 IL6 IL4 IL5 IL1B PMC8541937__F6 Network pharmacology of triptolide in cancer cells: implications for transcription factor binding ERG HEL-S-11 PMC8027777__F9 Graphical illustration of proposed DEX-mediated preservation of mitochondrial fusion and fission involved in regulating HIF-1a/HO-1 pathway MFN1 MFN2 FIS1 OPA1 PMC7332729__F5 Influence of MCR on critical signaling pathways involved in embryonic myogenesis EIF2S1 EIF5B MCM3AP ULK1 IGF1R HDAC3 MAML3 EIF2B1 SMAD2 LFNG ULK2 ADAM19 NOTCH3 E2F3 CDK6 FZR1 GADD45B BMPR2 DLL4 RPS6KC1 CDK4 EIF4A3 WNT7B ANAPC15 PIK3IP1 RBPJ BMP1 GADD45G SUI1 DTX2 BMPER VEGFA AMHR2 CDC25B DVL3 IGFBP5 PIK3C2B PIK3R5 MCM3 CDC20 E2F7 MCM2 ZBTB12 CDC37L1 RPS6KA2 PMC8727744__F3 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy IDO1 NEDD9 IL6 CSF2 ARG1 IFNG STAT3 PMC11674667__F3 HIF signaling pathway in normoxic and hypoxic state EPO MMP2 VHL MTOR PMC8727744__F1 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy IDO1 CDK4 CCL2 ARG1 PMC4399085__F3 PRC2-independent transcriptional activation by EZH2 in cancer RBBP4 RELA RELB EZH2 SUZ12 EED STAT3 PMC7590591__F7 Pathway of anti-tumor activity of plumbagin in bladder cancer CDK2 MMP9 GSK3B MDM2 CCND1 CDK4 MTOR CDK6 CCNE1 BAX PMC4614629__F1 Schematic illustration of the targets of actions by spermidine in different pathways MTOR PMC8554324__F1 Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities MSC CD44 CXCL12 CD36 PMC9035692__F3 Clinical Potential of Dental Pulp Stem Cells in Pulp Regeneration: Current Endodontic Progress and Future Perspectives HLA-G HGF PMC6340995__F7 SNO profile of cell death network in Chagas disease (ChD) FGA ANXA1 CS FLNA TPM3 PSMB3 HSPD1 HEL-S-128m HEL-S-22 DKFZp761E1322 HBB YY1 HEL114 THBS1 PNP PMC5803173__F4 RBM20 structure and potential TTN splicing mechanism(s) regulated by RBM20 RRM1 RBM20 PMC5803173__F1 Striated sarcomere structure and TTN-mediated signaling pathway FHL1 SQSTM1 FHL2 NBR1 PMC6340995__F8 SNO profile of inflammation and immune responses network in Chagas disease VASP ANXA1 MPO CS FLNA HSPD1 PS1TP5BP1 STIM2 HEL-S-22 ANXA2 S100A8 GRB2 HBB YY1 CDK4 HEL114 THBS1 TCF4 PNP PMC7801429__F4 An ER signaling pathway network identified by IMPALA using Symmans data PIK3R1 CHUK CSNK2A1 EGFR MAPK14 WAS LCP2 INPP5D PTPN11 SRC JUN SNCA PRKCI FOS NR3C1 CRK CASP3 KHDRBS1 NFKB1 LCK LYN GRB2 JAK1 SHC1 STAT3 PMC3783160__F4 Model of the interactions of Rrp1 and Rrp2 with the mediators of two branches of HR DNA repair pathway and helicases Rqh1 and Srs2 SWI5 GC RAD51 SFR1 RRP1 PMC5940532__F2 Signal-transduction events in necroptosis PGAM5 PPM1B TLR3 MLKL IFNG PMC6336706__F4 Model showing the possible pathways of neuropeptide Y-induced neuroprotective effects in Alzheimer's disease NGF NPY BDNF PMC9462646__F4 Phase separation in immune regulation and immune-related diseases TBK1 CGAS TREX1 IRF3 PMC6846243__F7 Control case interaction visualized on RPGeNet showing the connections between NRL, NR2E3 and CRX retinal transcription factors CRX KAT2B LIF SMAD4 RORB RHO EDF1 AANAT TMEM37 FLT1 IGF1 PARK2 FIZ1 BANF1 PMC7368652__F2 GSK3B on myocarditis and dilated cardiomyopathy NLRP3 HMGB1 MMP9 S100A8 S100A9 IL1B PMC9412694__F4 Impact of Epitranscriptomics on Antiviral Innate Immunity IRF7 F3 RIOK3 IRF3 PTEN MAVS PMC7174132__F1 Epigenetics/Epigenomics of Triterpenoids in Cancer Prevention and in Health RUNX3 YAP1 SMAD2 NFE2L2 NOX4 PARP1 HNF1A IL6 MYD88 TNF LATS2 KDM5A MEF2D HNF4A SP4 CCNG1 HDAC2 EZH2 CDH2 SP1 TGFB1 SP3 TERT PMC5314913__F2 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases FH LCK RAB4A TNF TGFB1 IFNG PMC10535870__F9 Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats BCL2 MTOR BAX PMC9429646__F1 Lipid rafts in cancer stem cell: a target to eradicate cancer SUFU APC CXCR4 GSK3B CD44 SMO CD24 PMC9412694__F2 Impact of Epitranscriptomics on Antiviral Innate Immunity STAT2 IRF7 IRF9 IRF3 IFNAR2 RHD IFNAR1 MAVS PMC7368652__F3 Phosphorylated GSK3B on polycystin-1/2 mutation of polycystic kidney disease SOST GSK3B AJUBA MTOR PMC3315579__F4 Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era EGFR PTEN MTOR PMC7432215__F2 MUDENG Augmentation: A Genesis in Anti-Cancer Therapy? CASP3 APAF1 CASP9 FADD BAX PMC4835624__F1 Signaling through EGFR GRB2 PTEN MTOR PMC7826796__F1 Metabolic pathway of vitamin D (based on Feldman et al., 2014 , Jekinson 2019 and Dou et al., 2016 with own modifications) CYP27A1 NR1i1 CYP2R1 DHCR7 CYP24A1 CYP27B1 PMC7546314__F8 Cellular model summarizing potential mechanism of cucumber resistance to B MYC ERF PMC9030443__F3 Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies AMER1 TLR4 NXN RAC1 SEC63 CAMK2A FLII PMC2593077__F2 Hepatitis C and Innate Immunity – Recent Advances TBK1 TLR8 CD14 TLR7 IRF7 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 TLR3 PMC11591800__F2 MTOR signal pathway TBC1D7 BNIP3 ARF1 DEPTOR IRS1 RHEB PMC6827047__F1 Parallel outline of several physiological roles of the TGFB/p38, mitogen-activated protein kinase (MAPK), and P13k/AKT/mTOR signaling pathways TSC2 EGF TSC1 EGFR MDM2 GRB2 PTEN MTOR RHEB PMC6827047__F3 Targeted components of the MAPK and AKT signaling cascades by small-molecule inhibitors in cancer BRAF PTEN MTOR PMC8702080__F1 Genetic Insights into the Impact of Complement in Alzheimer’s Disease HEL-S-62p CD59 C9 CS C4B_2 VTN FH C7 C6 CR1 PMC4152843__F5 Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries SPARC MHC2TA APOL3 EHF CXCL3 LPA CD74 SELL BMX UBA7 IL10RA SELE CD14 IL13RA2 IGLL1 RGS4 PTGS2 PRKD2 FUCA1 DGKA HLA-F HEL-S-125m IL15 VCAM1 CXCL9 HLA-DMB PYCARD PMC6027262__F4 Pathway overview of Salmonella carbon metabolism under Pi starvation RPIA RPE HEL-S-133P PMC6801800__F6 Endogenously derived chemerin mediates a tumor-suppressive effect through inhibition of Wnt/Beta-catenin signaling in adrenocortical carcinoma APC GSK3B PMC6520904__F7 CXCR7-EGFR crosstalk and its effect on the MAPK signaling pathway EGF EGFR CXCL12 PMC7655184__F1 Summary scheme of the cholesterol-mediated hepatocyte and stellate cell crosstalk pathway in NASH IHH LATS1 PMC5561110__F12 Schematic representation of C5b-9-induced lysosomal dysfunction that inactivates autophagy in podocytes C9 C7 C6 PMC5314913__F1 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases AMBRA1 AKT1S1 PTEN MTOR ARF1 DEPTOR RHEB STAT3 PMC11061361__F2 LIPUS holds potential as an effective approach to counteract synovial inflammation and fibrosis NLRP3 HEL-S-30 SQSTM1 CCND1 IL1B PMC11061361__F3 LIPUS regulates chondrocyte function via multiple pathways CS VEGFA SRC RHO ACAN MTOR SOX4 CTGF PMC6610330__F4 Model illustrating potential effects of cold stress on membrane lipid pathway in peanut PC PGP LPA PAH PMC4228940__F10 Novel Role of Vascular Endothelial Cadherin in Modulating c-Src Activation and Downstream Signaling of Vascular Endothelial Growth Factor CSK SRC PMC7888617__F2 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone EGF BAD EGFR SMAD2 GSK3B PTEN MTOR PDPK1 CCND1 SP1 JUN WNT16 FOS ERBB3 APC HBEGF NRG1 RAC1 IRS1 RHEB TSC2 RPS6KB1 TSC1 ERBB2 GRB2 PIK3CA BCL2 STAT3 PMC9064865__F5 6-Hydroxydopamine Induces Neurodegeneration in Terminally Differentiated SH-SY5Y Neuroblastoma Cells via Enrichment of the Nucleosomal Degradation Pathway: a Global Proteomics Approach KL ENG COMP PMC7888617__F4 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone EGF BAD EGFR ERBB3 APC MYC HBEGF RAC1 MTOR RHEB ERBB2 GRB2 CCND1 BCL2 SP1 PMC7888617__F3 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone EGF BAD EGFR APC MYC HBEGF NRG1 PTEN RAC1 MTOR IRS1 RHEB TSC2 ERBB2 GRB2 CCND1 BCL2 SP1 STAT3 PMC2893383__F2 Schematic of leptin signaling through STAT3 and PDE3B pathways in POMC and NT neurons in the hypothalamus PDE3B POMC IRS1 STAT3 PMC11312684__F2 GPx4 in the ferroptosis regulatory pathway: (a) GPx4 catalytic cycle representation SLC7A11 SLC3A2 IPP HMGCR PMC3931425__F1 Diagram of known egg activation pathways in Drosophila, Xenopus, and mouse CORT CDC20 APC PMC11550995__F5 Noncoding RNAs in rheumatoid arthritis: modulators of the NFKB signaling pathway and therapeutic implications BCL10 EGFR RELB CD40 MYD88 TRAF2 LTBR STAT3 PMC8615218__F3 Siglecs as Therapeutic Targets in Cancer SOCS3 SRC SYK PMC11550995__F3 NFKB signaling pathway BCL10 EGFR RELB CD40 MYD88 TNF TRAF2 LTBR STAT3 PMC11312684__F1 GSH synthesis and transport of precursor amino acids: (a) Gamma-Glutamyl cycle of GSH synthesis SLC7A5 SLC1A4 SLC7A11 CD44 SLC3A2 GLS PMC11868168__F4 Metastasis from other organs to lungs via exosomes LIN28B HEL25 KLF4 COL6A1 ARHA KLF2 CXCL12 KDM6B PMC4171341__F3 Change or Die: Targeting Adaptive Signaling to Kinase Inhibition in Cancer Cells NF1 ULK1 BAD PTEN MTOR IRS1 PMC9638134__F6 Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder CTSK DAO IRF9 OSCAR LTB RAC1 TNF IFNG TRIM23 LTA BCR ATM BASH CYLD FHL2 SYK LAT PMC11868168__F3 Lung cancer metastasizes outward through exosomes YAP1 RAB27A PTEN SOX4 SIRT3 PMC3159098__F2 Different RNA processing events in mammals SEPSECS TSEN34 PSTK RARS2 TSEN54 TSEN15 TSEN2 PMC9659743__F2 Dynamic and static biomechanical traits of cardiac fibrosis TRPV4 PIEZO1 RHO ATR PMC8262210__F5 Wnt3a/Beta-Catenin/CBP Activation in the Progression of Cervical Intraepithelial Neoplasia SOX2 WNT3A TP63 KLF4 PMC5297658__F1 Representative apoptosis pathway and associated factors FADD BAX PMC4832395__F4 Regulation of de novo lipogenesis by SREBP1c and ChREBP F2 GSK3B PKLR ELOVL6 PMC3683958__F3 The dynamic regulation of NAD metabolism in mitochondria NAMPT PNP NRK PMC11889932__F4 Regulation of ferroptosis through the interaction of iron metabolism and the STAT3/NRF2 pathway OGFR GPX4 AHR STEAP3 KEAP1 SLC7A11 FTL STAT3 PMC3912738__F1 IGF signaling involvement in EMT GSK3B GRB2 SHE PTEN IRS1 PMC7484674__F6 Top 3 modules with relatively high scores from the protein-protein interaction network E2F8 CRISP3 RAB27A CCL5 UBE2T SLPI ORM1 PNOC SLC2A3 PGLYRP1 TCN1 CFP FOLR3 LCN2 FPR2 IL8RB HEL110 CYBB TMEM63A FCGR3B MCEMP1 PTX3 CDC20 TIMP1 TAS2R41 HJURP CXCL12 DEPDC1B CD36 OLR1 CLEC12A CXCL1 RETN KIFC1 OSCAR FEN1 FCER1G LILRB2 CXCL6 BST1 CDC2 FCAR ARG1 CHI3L1 MGAM SLCO4C1 CXCR1 MMP9 C3AR1 NMU CCNB2 HEL164 GPR84 PMC11889932__F3 Regulation of ferroptosis by JAK/STAT signaling pathways, focusing on the roles of different STAT proteins, including STAT1, STAT3, and STAT6, in modulating ferroptosis through pathways like SLC7A11 and GPX4 (Amino acid metabolism) STAT1 CXCR3 GPX4 SLC7A11 CXCL10 HEL-68 HEL-S-64p JAK1 MCL1 SYVN1 SOCS1 STAT3 PMC11889932__F2 This diagram illustrates the interconnected pathways involved in ferroptosis GPX4 LPCAT3 STEAP3 FACL4 KEAP1 HEL-S-64p ALOX15 PMC3912738__F5 Proposed model for the interaction between Shh and IGF signaling GSK3B SHH SMO BMI1 MTOR IRS1 PMC3912738__F4 The cross-talks between the Notch and the IGF signaling PTEN HIF1A MTOR IRS1 PMC11889932__F6 Ferroptosis and STAT signaling pathways by various compounds in cancer models STAT1 GPX4 LPCAT3 FACL4 GC HEL-S-64p ALOX15 MTCH1 STAT3 PMC3912738__F3 The interplay between the canonical Wnt/Beta-catenin pathway and IGF signaling LEF1 APC GSK3B MTOR IRS1 PMC11889932__F5 Interaction of lipid metabolism pathways of ferroptosis with STAT proteins in human diseases STAT1 LPCAT3 FACL4 CPT1A ALOX15 ACSL1 IRF-1 STAT3 PMC6677151__F6 The inhibitory effect of Gal-3BP on TAK1-dependent NFKB signaling pathway TLR4 LGALS3BP TRADD IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TRAF2 IL1B TAB3 PMC4084431__F1 Genes directly related to dopamine functioning TH DRD5 DRD3 DDC MAOA DRD1 DRD2 DRD4 PMC3000440__F1 Decorin effects as an antiproliferative (left panel) and proliferative (right panel) molecule EGFR MTOR PMC12066429__F5 Metabolic pathway reconstruction of M CYS1 HEL107 FADD HEL-S-162eP PMC11818536__F3 Tumor suppression and promoting mechanisms of LACTB GPX4 LACTB TWIST1 SLC7A11 MTOR PMC9476737__F4 Cytotoxicity of oleanane type triterpene from leaf extract of Pterospermum acerifolium (in vitro) and theoretical investigation of inhibitory signaling pathway TSC2 TSC1 PTEN MTOR PMC7468896__F7 LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling PMC5696504__F7 Osteogenic Wnt/Beta-catenin pathway and its interplay with polyphenols RUNX2 APC SOST BCL9 PMC3918413__F4 Transforming growth factorB (TGFB) signalling pathway SMURF2 SMURF1 SMAD1 TF DKFZp781O1323 PMC3619006__F1 Proposed model for PDGF-D signaling pathway that controls the processes of EMT PDGFD CXCR4 MTOR PMC2647780__F1 Signaling Logic of Activity-Triggered Dendritic Protein Synthesis EEF2 EIF4E BDNF RHEB PMC5733023__F9 A schematic depicting the role of TLR4-NFkB-Caspase-11 signaling pathway in METH-induced astrocyte-related neuroinflammation NLRP3 IL16 TLR4 IRAK4 MYD88 TIRAP PMC4176946__F2 Ketone bodies as signaling metabolites FGF21 TSC1 SIRT4 FOXO3A SIRT5 NR1C1 SIRT1 FOXA2 SIRT3 PMC4736186__F11 Schema of signaling pathway involved in IL-1Beta-induced inflammation in microglia COX2 TLR4 IL1R1 MYD88 IL1B PMC6707123__F2 Schematic representation of the neural circuitry underlying the control of circadian rhythms NPY NPS PMC8875753__F1 miR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensis ARG2 NOS2 ARG1 PMC7831311__F7 Important pathways affected by long-term 1-MCP treatment CS ACO2 DLD ACLY CAD HEL-S-32 PMC11014885__F4 Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway ETHE1 HEL20 SUOX PMC3761221__F4 Fear learning and memory across adolescent development Hormones and Behavior Special Issue: Puberty and Adolescence HEL-S-11 CA3 PMC4428600__F1 Wnting out ocular neovascularization: using nanoparticle delivery of VLDL receptor extracellular domain as Wnt pathway inhibitor in the retina LRP5 LRP6 PMC5673678__F4 iCOS pathway associated with HIV-1 TAR target genesiCOS signaling in T helper cells BAD CSK GAB2 APC LCK VAV1 GRB2 CD40 CD80 PTEN RAC1 ICOS PMC4723085__F4 Uncovering New Pathogen–Host Protein–Protein Interactions by Pairwise Structure Similarity UBE2D1 PPP5C UBE2D3 HEL-S-71 MAPK14 ARHA CDKN2A PRDX3 FAF1 DKFZp761E1322 NFKBIA PSMD10 MAPK11 PMC6608049__F2 Molecular pathways involved in the maintenance of the MDSC suppressive function.A wide variety of proinflammatory factors are involved in the induction of the suppressive function in MDSCs STAT1 COX2 IL7 IL3 IL2 IL6 IL4 IL5 CD74 STAT3 PMC9309082__F2 Copper in the tumor microenvironment and tumor metastasis ATOX1 HDAC1 TET1 MEF2D PMC10878147__F1 Illustration represents the polyphenols targeting the NFKB pathway associated with Alzheimer's disease NLRP3 APP TNF PMC4823852__F8 MicroRNAs upregulated in OSCC repress multiple genes in the p53 signaling pathway MYC RRAS PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 PERP ATM CDK2 MDM2 CASP9 ATR BAX PMC4823852__F7 MicroRNAs downregulated in OSCC target multiple genes in the PI3K/AKT pathway CHUK BAD PTEN RAC1 EIF4E MTOR HRAS RHEB TSC2 PI3 BCR MDM2 SYK RPS6 BOLL CD19 PMC7765227__F3 Signal transducer and activator of transcription (STAT)1 and STAT3 pathways in the inflammatory response STAT1 PIM1 IRF7 CCL5 UBA7 SOCS1 STAT3 PMC7765227__F2 Role of the inflammation-associated transcription factor signaling pathway (NFKB) and mitogen-activated protein kinase (MAPK) pathways in the inflammatory response VCAM1 TRAF6 MYD88 IL1B PMC3342067__F4 CD44 potentiates T cell activation, expansion, contraction, and maintenance of memory cells APC LCK ZAP70 IL7R CD44 CASP8 CD69 PMC8961894__F1 DNA in extracellular vesicles: from evolution to its current application in health and disease CD9 CD63 RAB31 CD81 PMC5074356__F1 Signal transduction mediated by the extracellular calcium-sensing receptor (CaR) HEL-S-11 ARHA PMC2814543__F4 Nutrient sensing and inflammation in metabolic diseases TSC2 SOCS3 TNF MTOR RHEB PMC6196465__F5 Lipid synthesis pathway in porcine mammary gland ACACA ADFP ACSS3 ACSS2 LPIN2 GPAM DGAT1 FADS2 SCD ELOVL1 PLIN5 FADS1 XDH ACSL3 BTN2A1 FASN CD36 PMC6196465__F3 Milk protein synthesis pathway in porcine mammary gland LALBA LAT2 PMC6196465__F2 Lactose synthesis pathway in porcine mammary gland LALBA B4GALT1 HK2 PMC2715245__F7 Comparison of models for FRAXA and APC-inducible chromosome fragility ATM APC ATR PMC4175348__F11 A putative scheme for ATF3-mediated regulation of ER stress-induced cancer chemokine expression EGR1 ATF3 PMC7847067__F1 Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism GPR19 NOTCH1 PDK4 PMC4919024__F6 The pathway of EGF induced anticipatory UPR activation EGF EGR1 FOS BIK EIF2A PMC4184971__F4 Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention RIPK1 MAP2K4 CAD BMF NUMA1 FADD SUMO1 BAX PMC11541728__F2 Signalling pathway of ephrin receptors (EphR) is depicted SRC RHO RAC1 CDC42 PMC6445055__F6 Gene networks and canonical pathways generated by Ingenuity Pathway Analysis SP110 VHL RPL30 RPL10A EZH2 SPCS2 VDAC3 CP MRTO4 PMC4797117__F2 ML-hGRN for putative pluripotency renewal pathway in human embryonic stem cells PRDM14 SET SKIL ZNF580 FUS CEBPZ DPPA4 ENPP2 GTF2F2 REST OTX2 SCML2 ZIC2 PBX3 NFYB ZIC3 STAT3 OPA1 PMC4811486__F5 NF-Y activates genes of metabolic pathways altered in cancer cells MTHFD2L SLC25A32 SHMT1 GPT NNT MTHFD2 GOT2 GC HEL-S-70p CAD GCSH ME1 PFAS ME2 DLD SLC18A1 PHGDH GFPT1 PSAT1 DHFR PSPH GLDC SLC3A2 HEL-S-51e AMT GLUD1 GLS MTHFD1L PMC7702664__F5 Visualization of KEGG pathway of the genes altered in the CUBN neighborhood in CRC LRAT HEL-S-11 PMC8415109__F1 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis AMOT BIRC5 CTCF VGLL4 MYC MARK4 ARHA LATS1 NLK TIAM1 NF2 CCND1 CDC2 AXL PMC7382314__F7 Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney TNF HES1 PMC2720031__F1 GR signal transduction pathway IGF1 CX3CL1 TPR PMC8206466__F1 Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant BCL2 HEL-S-44 STAT3 BAX PMC6485955__F4 FGF21 Signaling Network in Adipocytes ATF7 FGF21 NCBP1 MAP2K4 UCP1 MAPK3 MTOR RHEB BCL6 MLST8 FGFR1 GAB2 GRB2 MAPK1 CRTC2 NFIA PMC5467317__F1 Cholesterol and isoprenoid synthesis pathway which shows the inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase by statins ARHA RAC1 CDC42 PMC5434646__F6 Proposed mechanism of the interplay between mitochondrial complex II and FH in the stabilization of the HIFA signaling pathway TH SDHC FH SDHD SDHA SDHB PMC6839211__F8 MicroRNA-182 in ovarian cancer KIF23 RPA3 BIRC5 YES1 GINS1 TOP2A ORC3 DTL ORC2 CDK6 MCMBP FYN PRC1 ECT2 CCND1 RAD51 CDK4 MCM10 GINS2 ORC6 GINS3 MCM7 CDC45 MCM3 MCM5 MCM6 HMMR MCM2 CDKN1A CDC6 BRCA2 NCAPG SMC2 GINS4 ORC1L SMC4 PMC5946182__F4 Proposed anti-inflammatory pathways based on reviewed nutritional interventions COX1 CRP IL6 PMC8466575__F8 Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy TRPC1 APC ARF6 PMC12103778__F5 Cytoneme-mediated Wnt signaling in gastric cancer WNT3 LRP5 LRP6 ROR2 PMC12103778__F4 Cytoneme-mediated self-organization and asymmetric cell division in stem cells WNT3A PMC9198382__F4 Advances in the systemic treatment of therapeutic approaches in biliary tract cancer BRAF ALK GRB2 PMC8468691__F6 4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells APAF1 CCNB1 CCND1 CDK4 CDC2 MTOR BAX PMC3248149__F3 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence TSC2 TSC1 MDM2 PTEN EIF4E RPS6 RHEB GAS2 PMC3175103__F4 Dysregulated TRK Signalling is a Therapeutic Target in CYLD Defective Tumours NTF3 MAPK6 UBE2L3 CYLD NTRK1 MAPK7 NTRK3 TRAF6 BCL2 NTRK2 PMC3248149__F1 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence MDM2 CCND1 BAX PMC4302087__F3 MiR-101 network regulates EMT ZEB2 EZH2 PMC5499908__F1 Force transmission and mechanotransduction from the extracellular matrix (ECM) to the nucleus SUN1 LBR FRK NR1B3 RHO mkl1 PMC3066468__F7 Scheme of cross-talk interactions between liver IR and TIM-1 signaling CXCL1 CXCL2 IL1B PMC10534675__F1 Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases BMPR2 PAH PMC5070052__F4 Schematic presentation of how the rs17228616 single-nucleotide polymorphism (SNP) in the acetylcholinesterase (AChE) gene may affect the vulnerability to stress ACHE CDC42 PMC3576812__F1 The hedgehog’s tale: developing strategies for targeting cancer SUFU PTCH1 SMO PMC2575905__F1 Current concepts of the amino acid signaling pathway leading to protein synthesis TSC2 EEF2K TSC1 EIF4E RHEB PMC4621105__F2 Common cellular processes important in coronavirus replication UBE2M COPZ2 DDX1 HNRNPL EEF1A1 ERF RPS7 EIF3E POLR2B KCNG1 SCD RSL24D1 UBE2I CCND1 DDX5 VNN1 EIF4B TMEM41B RPS20 GBF1 PPIH PPAN RBX1 PRPF6 PES1 PLRG1 EIF3F CDC5L CWC15 ARF5 KPNA2 SNRPD1 ATP2A2 RHBDD3 CLDN5 RNF128 VCP PRPF18 TMEM18 ABCE1 PMC9300927__F6 Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot PIK3R1 FBN2 IGF2BP1 SOCS3 ADAMTS9 FBN1 RAPGEF4 COL21A1 ABHD2 E2F3 SOX4 MTSS1 FURIN COL2A1 HEL-S-133P FREM2 ZNF385A LIMK1 P4HA2 STEAP3 HAS2 KLHDC3 CLCN3 MEGF9 CXCR4 AMOTL1 KPNA2 LITAF ANKRD33B KRABD4 LOXL4 NACC2 SLC7A11 GAS1 RHPN2 AQP4 MAP2K3 BCL2L11 TUBB2A TET1 BACH2 GPR137B E2F2 RRM2 opn F3 LDLR ZNF711 MKX PTGFRN MAP3K10 TNFRSF11B VLDLR SNN RGMA NREP STAT3 PDCD1 PMC5308720__F6 Expression/activation of A5B1 integrin is linked to the Beta-catenin signaling pathway to drive migration in glioma cells HEL113 PMC6775302__F9 Proposed signaling network of regulating the formation and development of seminal vesicle tumors in TRAMP mice EGF EGFR CCNB1 CCND1 CDK4 CDC2 EZH2 CDK6 STAT3 PMC6202086__F4 The mechanisms involved in the maintenance of b[Ca2+]i TRPC3 RYR2 PMC6896088__F3 Associations between the autophagy pathway and MAPK signaling in to tumor tolerance against targeted therapies and chemotherapies ATF4 ASNS ATF3 DKFZp686F0183 PMC6836113__F10 Continuous impaired insulin signalling causes the activation of AD markers (GSK3B and TAU genes), thus increasing the amyloid beta aggregations leading to AD VIT GSK3B PMC8415109__F3 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis TRPV4 ROCK1 ARHA PXN PMC7021704__F6 Main pathways in O PDC GAL HEL-S-5 PMC3492204__F5 A simplified scheme to illustrate the dual roles played by KIF7 in Indian Hedgehog (IHh) signaling and chondrocytes development IHH KIF7 SMO PMC6394552__F4 A feedforward mechanism in TGFB signaling SMAD2 SMURF2 TGFBR1 SMAD4 SMURF1 PMC11989323__F2 Biosynthetic pathway of NAPE and NAE NAAA GDE1 ABHD4 FAAH HRASLS5 PMC10037406__F5 Posttranslational modification in the cGAS-STING pathway TBK1 CGAS RNF185 MUL1 IRF3 SENP2 TRIM29 RNF5 TRIM13 AMFR TRIM14 TRIM38 RNF26 TRIM32 TRIM56 TTLL6 TTLL4 PPP6C RNF115 PMC10037406__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC6160542__F1 Fibrogenic secretome pathways in the development of fibrosis DKK3 GSK3B LRP5 LRP6 DKK1 SIRT1 PMC6714585__F21 Most potent small molecules capable of inhibiting Hh pathway with their mode of action SUFU PTCH1 SHH SMO PMC9259561__F4 PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway EGF RELN ITGB3 MPO ITGA2B PF4 F2RL3 PTEN FREM1 COL6A5 IRS1 PRL PLOD2 NMU CTSG PLAT GP5 FGF10 GRB2 AVP VWF ELANE MAGI1 COL6A6 PMC8366450__F5 Human CPPED1 belongs to calcineurin‐like metallophosphoesterase superfamily and dephosphorylates PI3K‐AKT pathway component PAK4 PHLPP2 HEL-S-28 PDK2 PAK4 PTEN CPPED1 PMC5329687__F1 Nitric oxide dose effect on mitochondrial function and endoplasmic reticulum stress CRIPTO TFAM PMC8880704__F9 Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus OLR1 UCP1 PCK1 APOC3 CPT2 HEL-S-104 CYP7A1 PDPK1 ACOX1 UBC CYP27A1 CYP8B1 AQP7 SCD LPL APOA5 ACSL1 ME3 NR1H3 APOA2 SLC27A4 ANGPTL4 HEL-S-28 ADFP HMGCS1 RXRA DBI PLTP FADS2 ACADL SLC27A5 EHHADH ACADM CD36 FABP1 PMC3443185__F1 Two mechanisms underlying circadian control of NFKB response CRY1 CRY2 PER2 PMC11573773__F3 Regulatory pathways of ABCC5 in cancer KEAP1 FOXM1 BMI1 ABCC5 PMC11573773__F2 SLC34A2-Bmi1-ABCC5 signalling pathway hypothesis diagram SLC34A2 BMI1 ABCC5 PMC4640739__F7 Working model for Mek/Erk signaling in mouse ESCs PRDM14 TBX3 KLF4 PMC3889255__F1 CRH signaling pathway - This map represents the NetPath reactions of CRH signaling pathway PLCG1 CRHR2 PRKCE BRAF MAPK3 PLCG2 DKFZp686L0365 PRKCA POMC GNAZ TFAP2A ECE1 JUN TEX19 STAR FOS PARP1 ARHA GNA11 NFKBIA MAP2K1 NFKB1 CRH RELA BCL2 GNAO1 GNB1 TCF4 PMC9221189__F5 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway OGT SMAD2 DLL4 GSK3B LRP5 SMAD4 LRP6 LATS1 RHO LATS2 TCF4 PMC2926749__F4 Proposed model for MALT1 function in NFKB activation BCL10 BCR TRAF6 PMC9536081__F6 Absence of ID2 results in an altered photic responsiveness of the circadian system GIG8 PER1 PMC8616424__F1 Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease NLRP3 CGAS TLR9 IL1B BAX CD36 PMC9365986__F2 Immunoregulation effect of tumor microenvironment in pancreatic ductal adenocarcinoma CD44 CD24 PMC4425275__F3 Original and reduced EGFR models EGF NGF NGFR EGFR RAF1 PMC8761737__F8 Transcriptomic and Histological Analysis of Exacerbated Immune Response in Multidrug-Resistant Pseudomonas aeruginosa in a Murine Model of Endophthalmitis NLRP3 MPO TIMP3 GFAP TRAF6 TNF PMC6186418__F2 YAP/TAZ upstream signals and downstream responses TIAM1 APC LRP5 LRP6 LATS1 RHO LATS2 PMC6757264__F7 Mitogen-activated protein kinase signaling pathway in lung squamous cell carcinoma CD14 NLK MAX FLNA TRAF6 TNF JUN BAP1 PMC5302973__F7 Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells TWIST1 GSK3B CD44 PMC6981639__F1 The primary metabolic pathway of mammalian gangliosides GM2A ST8SIA5 A4GALT UGCG B3GNT5 B4GALT5 B4GALNT1 ST8SIA1 B3GALT4 ST3GAL5 PMC2696359__F1 TNF-Induced MAP Kinase Activation Oscillates in Time TRADD TRAF1 CDC37 TNF TRAF2 PMC8171813__F1 Immune cell involvement after cardiac injury NLRP3 CCR2 CRP PMC8326758__F1 Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms FGF21 FYN PON1 BAX PMC8698717__F3 Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology COX1 VCAM1 VWF IL8RB PMC3797807__F4 Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1 TH FLNA MYC TRAF6 IL1R1 HSPD1 CD74 TXN PRDX3 CDK7 IFNG DKFZp686L0365 HINT1 AHR CASP9 CYP1A1 NOS2 SELE GCLM PPP5C MS4A1 MAP3K5 TNF RBX1 CUL4B RELA BCL2 TXNIP HEL-S-100n TPT1 GLS PSME2 PMC4168754__F1 Cardiac Hypertrophic Response pathway loaded as a pathway GSK3B MTOR COMP HDAC5 CDK7 POLI PMC9345703__F8 Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways TBK1 STAT1 CGAS OAS3 IRF3 IFNAR2 JAK1 IFNAR1 TLR3 IFIT1 PMC6459169__F4 Transcriptional coverage of penguin transcripts on the vertebrate Janus kinase/signal transducers and activators of transcription (JAK-STAT) (#04630) (A) and vertebrate Toll-like receptor (TLR) signaling pathway (#04620) (B) CD14 MAFK PIR LAT PMC7765985__F2 Networks generated from genes altered in intestinal- and diffuse-type gastric cancer (GC) RALA PAH PMC6459169__F3 Transcriptional coverage of penguin transcripts within the vertebrate nuclear factor kappa B (NFKB) signaling pathway (#04064) LEP LTA DAO BASH LBP LTB TRAF6 MIP TNF LAT PMC11936485__F8 Mechanism and signaling pathways of the inhibitory effects of HST on the proliferation of LUSC cells CASP3 EIF2A CCNB1 NOTCH1 CDC2 BAX PMC7473788__F5 Working model proposing how TFAP2C functions downstream of the Hippo signaling pathway to regulate Cdx2 expression in the outside polar cells SOX2 CDX2 AMOT YAP1 NF2 TFAP2C TEAD4 LATS1 LATS2 PMC7473788__F4 Working model proposing how TFAP2C and TEAD4 promote formation of the apical domain, which in turn, negatively regulate LATS1/2 activity in the outside polar cells ROCK2 ROCK1 PARD6B TFAP2C TEAD4 ARHA LATS1 LATS2 PMC7473788__F3 The Hippo signaling pathway in mouse preimplantation embryos CDX2 AMOT YAP1 NF2 TEAD4 LATS1 WWTR1 LATS2 PMC9221189__F1 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway LATS1 LPA LATS2 PMC183833__F2 Canonical Wnt/Beta-catenin pathway TBP APC LRP5 CCND1 FRAT1 PMC4015472__F3 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways STAT1 STAT4 IFNGR2 JAK1 IFNGR1 IFNG HEL-S-162eP PMC4015472__F2 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways IRF7 IRAK1 TRAF6 IRAK4 IRF3 MYD88 MYH7 IFNAR1 MAP3K7IP1 MYH7B TLR7 TLR4 TYK2 JAK1 PMC9530146__F6 Mechanisms of acupuncture for neuropathic pain based on somatosensory system CX3CR1 CX3CL1 BDNF PMC3504364__F2 Methotrexate (MTX) mechanisms of action in the folate metabolic pathway GGH DHFR ABCC1 MTRR INS MTHFD1 ABCG2 FPGS ABCC2 ABCB1 SLC19A1 PMC4419202__F4 Upstream analysis focused on transcription factors after Foxa1 knockout in female bladders CD133 TCF3 FOS TP63 MDM2 RELB NOTCH1 TAF4B RBL1 KRT10 PMC4419202__F3 Most enriched pathways after Foxa1 knockout in female bladders TP63 MDM2 RELB REL PPBP KRT12 KRT10 PMC6534496__F6 Outline of the main altered pathways in SiNETs EGFR SMAD4 PTEN MTOR MSH6 SRC IPMK MSH3 HEL-117 MSH2 MSH4 CDKN1B APC LRP5 VHL LRP6 MAP2K2 FZD5 PMS2 TSC2 TSC1 CDKN1A LRP4 MUTYH OGG1 PMC4419202__F1 Most enriched pathways after Foxa1 knockout in male bladders TNLG2A KLF6 ORM1 PMC8302727__F2 Proposed biosynthetic pathway of ARTs based on the two-polyketide-chain assembly model ART4 PMC10904539__F2 AhR in tumor energy metabolism AHR SUV39H1 HK2 HEL-S-162eP PMC8402591__F1 Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review EPO APC CD80 MTOR PMC6005849__F4A Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions TH CTSK RAE1 CYLD FHL2 GRB2 SYK RAC1 TNF IFNG PMC6956807__F8 Proposed model for miR-204-5p-SNAI2/SUZ12/HDAC1/JAK2/STAT3 regulatory circuit in HNSCC progression SNAI2 EZH2 SUZ12 STAT3 PMC9310501__F4 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis LIF MMP9 OSCAR STAT3 PMC8845065__F6 Retinoic acid synthesis and signaling DHRS9 RARA RARB CRABP2 ALDH1A3 HEL-S-53e ALDH1A2 PMC9310501__F3 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis SOCS3 WNT4 LIF RPN2 LEPR CEBPA RAC1 STAT3 PMC8385858__F8 Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer MMP2 CCND1 BCL2 CDK4 CD69 PMC11019011__F3 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity IL18 IGF1 RUNX2 AXIN1 IL6 RHO AXIN2 DNMT3B DACT1 PMC4280579__F7 Integrated model of NDV-3–mediated protective efficacy versus MRSA in murine SSSI IL16 APC STAT3 PMC11019011__F5 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity IL18 RUNX2 NFATC1 IL6 DKK1 PMC11019011__F4 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity RUNX2 SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7582838__F2 Modified tricarboxylic acid (TCA) pathway in cyanobacteria PDC PMC11019011__F6 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity IL18 NFATC1 IL6 PMC5002299__F3 Regulation of the NLRP3 inflammasome activation by the ubiquitin-proteasome system NLRP3 IL16 TRAF3 TRAF6 BRCC3 PMC5002299__F1 Regulation of TLR4 signalling by the ubiquitin-proteasome system USP4 USP15 TRAF3 USP20 TRAF6 IRF3 MYD88 USP18 TLR4 CYLD OTULIN MYSM1 TAB3 MAL PMC4384737__F2 Nucleotide sugar UDP-GlcNAc resides at the nexus of protein and lipid glycosylation PGM3 OGA OGT TPR PMC8394439__F1 Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer IL10 GC IL22 LAG3 TNF NFATC3 FOXP3 PMC3825415__F3 FGFR signaling pathway FRS2 GRB2 SHB DOCK1 RHO ERAS CRK CDC42 CBL PMC3756518__F1 Schematic of the simplified B-cell receptor (BCR) signaling pathway simulated in our Monte Carlo method BCR LYN SYK PMC10300974__F5 Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties † HEL-S-28 EGFR S100A8 SRC IL8RB CXCL2 BAX PMC8005494__F2 Molecular mechanism of pyroptosis HMGB1 GZMA GSDMC GSDMB GSDMD STAT3 DFNA5 PMC4068285__F4 LM infection in microglia STAT1 CD14 BAD SMPD1 CCL4 JAK1 SCARB2 PMC9557975__F2 Activation of TLR4 by viral glycoproteins: A double-edged sword? CD14 TLR4 IRF3 MYD88 TIRAP PMC4253844__F2 Cholesterol in brain disease: sometimes determinant and frequently implicated ABCA1 APOE PMC9604348__F10 Transcriptomic and Physiological Analyses Reveal Potential Genes Involved in Photoperiod-Regulated Beta-Carotene Accumulation Mechanisms in the Endocarp of Cucumber (Cucumis sativus L.) Fruit MYB CSNK2A1 RFWD2 PMC4253844__F1 Cholesterol in brain disease: sometimes determinant and frequently implicated NPC1 DHCR7 DHCR24 NPC2 HMGCR PMC5005280__F3 Core Hippo pathway TEAD3 NF2 TEAD4 LATS1 TEAD2 PMC5751143__F1 Induction of PD-L1 by IFNG signaling pathway and microRNAs target the key genes in the pathway PTEN MTOR EIF4B IRF-1 PMC7343830__F6 Proposed regulatory mechanisms of blood circulation for hypoxic adaptation in Tibetan chickens NUMB NCALD MTOR PLCB1 MLST8 HEL-S-102 STK4 EMP2 CTSA NLN CASQ2 APOH ACE2 HK2 VAV2 PMC8487426__F4 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the amygdala (AMY), the caudate nucleus (CN), the cerebellum (CRB), and the hippocampus (HIP) of AUD subjects (the Set 1 sample) INA SYT9 THBS1 HMOX1 CP PMC8487426__F5 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the nucleus accumbens (NAc), the prefrontal cortex (PFC), the putamen (PUT), and the ventral tegmental area (VTA) of AUD subjects (the Set 1 sample) ARHG WAS CP PMC8323660__F2 Epigenetic Changes in the Progression of Alcoholic Steatohepatitis UFM1 PNPLA3 UFSP1 MTF1 SIRT6 UFC1 SIRT1 SIRT3 PMC8381650__F5 NFKB: At the Borders of Autoimmunity and Inflammation CCL21 BCL2 AIRE IRF4 FOXP3 PMC8381650__F4 NFKB: At the Borders of Autoimmunity and Inflammation TRADD IRAK1 TRAF6 IRAK4 MYD88 NOD2 CARD11 BCL10 BCR TRAF5 LCK LYN ZAP70 SYK TRAF2 OTULIN PMC3560853__F3 Scheme showing the potential molecular events induced in cancer cells in the hypoxic tumour microenvironment SOX2 HEL-S-30 CXCR4 MYC VHL BCL2 IL6 ABCG2 MTOR HEL-S-68p PMC8476812__F6 Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way MHC2TA RUNX3 SOCS3 FOXO3A CDKN1B MYC TNF CDKN1C SOX4 FOXC1 MMP7 SIAH1 MMP2 BIK CXCR4 FOSB NOTCH1 KLF2 RAD51 EZH2 GREB1 PER2 PMC5562928__F2 Amino acid degradation in I HAL DLD AASS FICD GSTZ1 GOT2 KYNU PRODH SUOX AFMID GLDC AMT GLS GCSH PMC9598921__F4 Chromosome-Level Assembly of Male Opsariichthys bidens Genome Provides Insights into the Regulation of the GnRH Signaling Pathway and Genome Evolution EGR1 MMP2 GRB2 CDC42 PMC5562928__F1 Amino acid synthesis in I CTH PSAT1 ASPG PAH PHGDH AGXT2 PMC9133560__F4 Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles APC LRP5 SHH LRP6 TNLG7C SMAD1 DKFZp781O1323 PMC7417299__F5 Chemokine signaling pathway from KEGG has the highest counts for selected feature genes BAD DAO GRB2 SHE ARHA PMC2585609__F1 A schematic representation of the functional domains of Stim and Orai proteins ORAI3 ORAI1 STIM2 PMC6772062__F1 Canonical Wnt/B‐catenin and divergent signaling pathways LEF1 APC GSK3B LRP5 GSK3A LRP6 MTOR PMC7765110__F9 The proposed pathways by which melatonin regulates testosterone production and protects the testicular tissue from oxidative damage in LPS-induced sheep orchitis TLR4 SF1 IL1B STAR PMC3942726__F1 Simplified schematic diagram of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and proposed cellular regulation of muscle protein synthesis in response to hypoxia, caloric restriction, insulin, muscle contraction, and leucine TSC2 TSC1 EEF2 RPS6 RHEB PMC4491883__F1 NetworkPainter enables researchers to quickly draw publication quality signaling diagrams BTK BCR BASH ZAP70 SYK MTOR PMC8021759__F1 Methods to circumvent antiviral immunity STAT2 IRF9 KLRG1 PMC4830836__F1 Notch canonical and non-canonical signaling YY1 HIF1A PMC8955653__F2 An Expanding Toolkit for Heterochromatin Repair Studies ATM BLM TOPBP1 BRCA2 ATRIP RAD52 RAD51 LIG1 ATR DNA2 PMC8535589__F1 Cell Death and Survival Pathways Involving ATM Protein Kinase ATM GSK3B BAX PMC6386894__F3 cAMP regulates immune response of astrocytes HEL-S-62p VCAM1 CCL2 CSA2 PMC10952836__F1 Signaling pathways involved in ferroptosis regulation GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 ADA SLC3A2 TEAD2 PMC8624829__F4 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway PLCG1 MAPK3 MAPK14 ADRB2 ACHE CACNA1A CFTR CACNA1C PRKCA EDNRA PRKCB SRC PIK3CA ELANE CHRM2 NOS2 REL PPARG MYLK PMC6915518__F3 Molecular mechanisms of pro- and anti-inflammatory effects of NPs on MФs IL10 NLRP3 TLR7 TLR4 MARCO SRA1 CD80 IL1B TLR3 IFNG PMC7760557__F10 Melatonin in mitochondria of NLRP3−/− mice during cardiac aging NLRP3 MFN2 KEAP1 HMOX1 FADD AMT PMC120784__F11 Upper part of the glycolytic pathway and pathways for production of glycerol, trehalose, and glycogen, with all proteins and their isoforms indicated HEL-S-49 tal-1 PMC7236196__F7 Combined proteomics and metabolomics pathway network map of significantly altered metabolites and proteins in ERG-positive prostate cancer compared to ERG-negative prostate cancer PC ERG ACSL1 NTS APRT EHHADH PMC9043600__F1 Long Non Coding RNA Based Regulation of Cerebrovascular Endothelium PAK1 VEGFA BCL2 ULK2 TUG1 HIF1A STAT3 BAX PMC6626573__F6 Targeting of lung cancer stem cell self-renewal pathway by a small molecule Verrucarin J FOXM1 APC PMC8624829__F5 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway ChAT PROC MCU ACHE POR GAA PLN PI3 CAV3 BCR CYC1 HRC CAV2 PMC8026084__F9 IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling CHD4 CSA2 EZH2 DOT1L PMC7873355__F3 Interaction network showing the mutual involvement of DEPs from SACS KO model and ARSACS patients in Engulfment of Cells (A) and Synaptogenesis Signaling Pathway (B) SNCA ICAM5 EPHA3 EFNB2 APOE EPHB2 CP PER1 PMC4397846__F1 Pathway on the left is that of an active cell APC PMC5819688__F6 Anacardic acid and signaling pathways CHMP1A ATM GEM PMC6658002__F3 Other stimuli leading to necroptosis TLR4 STAT2 TNF FADD TLR3 MLKL PMC4681826__F1 Signaling pathways activated by BCR-ABL BAD GAB2 MDM2 GRB2 CRK CRKL CBL PMC6658002__F2 TNFR1-mediated signaling pathways TRADD TRAF5 CYLD TRAF2 FADD MLKL PMC8851069__F4 Advances in cGAS-STING Signaling Pathway and Diseases CGAS TFAM BAX PMC6594827__F2 Other fatty acid metabolism targets CPT1A MGLL KLF4 NR1C1 ACOX1 FASN PMC8851069__F3 Advances in cGAS-STING Signaling Pathway and Diseases NLRP3 CGAS IRF3 PMC8851069__F2 Advances in cGAS-STING Signaling Pathway and Diseases CGAS TLR9 MYD88 PMC3529804__F3 Novel Directions for Diabetes Mellitus Drug Discovery EPO MTOR SIRT1 PMC6880770__F6 Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways TH INA PMVK MVD ACADL FOS SPEN ACLY GAL PMC9590394__F1 T cell dysregulation in inflammatory diseases in ICU IL7R CASP9 CTLA4 LAG3 PMC10545798__F1 Landscape of cholesterol homeostasis regulation ACAT1 ABCG1 LDLR ABCA1 HMGCR PMC8716846__F6 Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury MYB BAD CD37 MEI1 MYC PTEN BRCA1 RHEB TSC2 BCR MDM2 GRB2 SYK GAL RBL2 CD19 PMC10545798__F6 Internal and external factor regulation of cholesterol metabolism PCSK9 MIEF2 ABCG1 LDLR PTEN ABCA1 TNF MTOR HMGCR PMC6372590__F5 PAK4 signaling in health and disease: defining the PAK4–CREB axis APC GSK3B MC1R PMC10545798__F8 Cholesterol affects tumor cells by modulating immune responses, ferroptosis, tumor cell stemness, and the DNA damage response GPX4 LPCAT3 FDPS IPP ZMYND8 HMGCR STAT3 CD36 PMC4447120__F1 AMPK is a negative regulator of the Warburg effect in Fumarate hydratase-deficient kidney cancer KEAP1 HEL-S-133P PMC3852103__F2 Most significant GeneGO pathway map EGF NR3A2 EGFR MAPK3 HRAS IRS1 PDPK1 IGF1 ERBB2 TFF1 GRB2 CCND1 MAPK1 NCOA1 RAF1 PMC3213160__F3 Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling IL7 EPO BCR ATM IL3 EGFR IL5 PMC3151497__F3 MAPK signaling pathway CD14 EGF SRI RAD1 NGF MOS FOS ATF2 EGFR MYC GCK TNF NLK MAX JUND CR2 PMC10286592__F3 Alteration of mTOR signalling pathway post TBI ULK1 TSC1 MTOR RHEB PMC4411872__F5 Genes involved in GPCR signaling Pathway: (G protein coupled-receptors are seven-transmemebrane receptors involved in signal transduction in humans) IL10 GNB3 EPO NPY BMP2 VEGFA BMP7 IL6 TNF TGFB1 BMP4 PMC10286592__F1 How TBI altered calcium dependent PLC pathways, oxygen species scavenging system and p53 signalling HMGB1 MYD88 PMC4411872__F7 Genes involved in chronic kidney failure (Disease Pathway) ENPP1 GNB3 CCR2 NR1i1 EPO REN NPY IGFBP1 SLC12A3 IL6 PMC4795462__F2 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease ACLY GLS PMC4795462__F1 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease PBRM1 ACLY SETD2 HK2 BAP1 PMC7456827__F1 Circadian regulation of complement immune system HEL-S-62p CRY1 CRY2 DBP NFIL3 RORA PER2 PER3 PMC9511957__F6 Toll-like receptor 2 signaling pathway activation contributes to a highly efficient inflammatory response in Japanese encephalitis virus-infected mouse microglial cells by proteomics TRAF6 IRAK4 MYD88 PMC4200202__F7 Simplified interaction map between the LOXL4 protein with the OS pathway by both protein-protein interaction analysis and literature mining DDR1 NRF1 LOXL4 BMP2 IGFBP7 CDC37 EXOC6 SUV39H1 ECSIT PKD1 COL2A1 TGFB1 SIRT1 PMC8357146__F7 Regulatory mechanism of ASPN and DCN: We have proposed a Schematic illustration of the mechanism based on our conclusion SMAD2 SMAD4 PMC2829627__F3 PPARG agonists inhibit Stat3-mediated IL-6 gene expression in myeloma cells EBP TRO STAT3 PMC2829627__F2 Tumor-associated angiogenesis is sustained through stromal microenvironment crosstalk HGF IGF1 PMC316768__F1 Model of somatic sex determination in C SDC1 SDC2 TRA2A SDC3 PMC6621453__F3 siRNA screening identifies TrkB, TrkC, and FGFR1 FGFR1 MTOR DYRK1A PMC9488581__F1 Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review MPO MUC5B TERT PMC8949863__F3 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity ISG15 OASL STAT2 ISG20 IRF9 TYK2 IFNAR2 PMC8949863__F2 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity CGAS IRF7 IRF3 PMC8038663__F1 Chemical structure and mammalian glycosphingolipid (GSL) biosynthetic pathway A4GALT UGCG B3GNT5 B4GALT5 B4GALNT1 UGT8 ST8SIA1 ST3GAL5 PMC2956880__F4 Schematic diagram showing the interaction of the p75NTR and TrkB signaling pathways BAD APAF1 UNK BDNF PMC9266652__F3 Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease NLRP3 CRIP2 MYD88 IL1B NOD2 PMC3822826__F2 Canonical Wnt/Beta-catenin signalling pathway APC WNT1 GSK3B TCF4 PMC3494605__F1 A role for vimentin in Crohn disease ATG16L1 NFKB1 NOD2 PMC5000717__F2 The Hippo/YAP pathway is physiologically initiated via GPCRs LATS1 LATS2 PMC4024337__F4 NFKB gene signature predicts prostate cancer progression DKFZp686L0365 RAB8A GDF15 F2 CCNB1 SRC ITPKA XDH TRPS1 HMGCR PMC5919979__F4 Proliferation-associated lncRNAs act on at specific functional sites of the Wnt signaling pathway MMP7 CCND1 PMC5919979__F2 Proliferation-associated lncRNAs act as p53 regulators or effectors by activating or inhibiting the p53 signaling pathway PMC5962695__F1 Extracellular matrix (ECM) in structural and functional synaptic plasticity SPARC MMP3 VLDLR PC MMP2 DAB1 PMC5919979__F5 Proliferation-associated lncRNAs act as MYC regulators or effectors by activating or inhibiting the MYC signaling pathway IGF2BP1 MYC MTOR PMC3351275__F3 Negative feedback and adaptive resistance to the targeted therapy of cancer PTEN MTOR PMC8851069__F6 Advances in cGAS-STING Signaling Pathway and Diseases CGAS DNASE2 TREX1 PMC6773825__F2 Main strategies of immunomodulation CD27 CCR7 MTOR PMC9569803__F19 Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis NLRP3 TLR4 RELA TRAF6 MYD88 PMC3457170__F4 JAK/STAT signaling pathway is targeted by RVFV NSs protein at different levels RNASEL EIF2S1 RNASE1 MED14 IFNA14 IRF9 IL22 EIF2AK4 IFNAR2 MAPK8IP3 PMC6487307__F12 Schematic summarizing the “reprogramming” of polyamine metabolism by iron-depletion in: (A) SK-Mel-28 human melanoma and (B) MCF-7 human breast cancer cells ADI1 SMOX SRM PAOX SLC3A2 AMD1 SMS ELL HEL-S-18 PMC5134922__F4 Ingenuity Pathway Analysis of the top overlapping networks in chronic beryllium disease and sarcoidosis PTGER2 SOCS2 SOCS3 CISH PIAS1 IL2RA BCL2L1 JUNB TNF IRF-1 PMC3221743__F5 Working model describing how in HIV+ macrophages constitutively activated PI3K elicits blunting of lipid A-induced increases in TNFA release through sustained mTOR activation TLR4 MYD88 MTOR PMC3872233__F4 Toll-like receptor 4 signaling pathway in alcohol consumption TLR4 IRAK1 IRF3 IRAK4 MYD88 PMC9225917__F12 Huangqi Sanxian Decoction Inhibiting Osteoclast Differentiation Based on Network Pharmacology MYB TSC2 BAD TLR4 BCR MYC GRB2 SYK RAC1 MTOR RHEB CD19 PMC6526672__F2 Signalling pathways involved in glucose metabolism‐regulated NLRP3 inflammasome activation NLRP3 SIRT2 EIF2AK2 HIF1A PMC8387394__F3 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer BIRC5 DKK1 LATS1 CIT NOTCH3 LATS2 SOX9 DRAXIN FOXD3 MMP2 FZD2 SRC SMO DDX5 CDH2 SKI ADAM9 WWC1 SOX2 FOXO3A MMP9 APC LRP5 ARHA ERBB2 CXCR4 GLI3 PTCH1 ADAM10 HEL-S-66 ERCC1 SOX10 CXCL12 STAT3 ITCH PMC5501640__F1 Sketch of Hedgehog (Hh) signaling pathway BOC SUFU GLI3 GSK3B SMO PMC8387394__F2 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer BAMBI HOXB1 POSTN SMAD2 FOXQ1 PAX7 PAX3 SOX9 EPHB3 HES1 MMP7 MMP2 ZEB2 MDM2 SHH MSX2 HAS2 IRS1 PTX3 HMGA2 CBX8 GRB2 UBAP2L EEF2K EGF IGF1R RUNX2 NODAL TGFBR1 EGFR TGFBR2 MSX1 PTEN RHO MTOR TRPM7 BMP4 FOXD3 E2F2 AXIN2 HAND2 GATA3 KRT14 PDGFRA BMP2 FGF2 MMP9 IGF2 LIF CD44 RAC1 HMGA1 LEF1 WNT3A ERBB2 HOXA1 JAK1 SASH1 STAT3 PMC6126134__F1 Nuclear factor KB (NFKB) activation signaling pathways.Canonical NFKB pathway: the canonical pathway is inhibitor of KB (IKB) kinase (IKK)-dependent and IKB-dependent BCR RELB CD40 LTBR PMC5297776__F3 MTOR signaling pathway as a target of molecular therapies TSC2 TSC1 PTEN PMC8387394__F5 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer CRHR2 CCR2 SOX2 GSK3B FOXE3 BMI1 HIF1A FAF1 CCND2 HES1 AKAP4 S100P FOXD3 GLI3 ZEB2 SATB1 SHH SMO CDK4 COL2A1 FOXR2 CERS6 STAT3 PMC3213966__F3 Regulation of cardiac hypertrophy by AKAP complexes RHO HDAC5 RYR2 NFATC3 PMC8387394__F4 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer SPARC NUMB PEAR1 HEL-S-15 DMXL2 SMAD4 BMI1 SOX9 ADAM17 FOXD3 MMP2 ATF4 MAML1 MFAP5 ITGB3 SOX2 BAG3 FTH1 MMP9 PCOLCE ARHA MMP16 DDR2 ITGB1 DMP1 ID1 HMGA1 SMAD9 KLK10 BCL2 TGFB1 STAT3 PMC6009094__F1 Wnt signalling pathway.Left: the Wnt pathway is activated by the interaction between LRP5/6, Wnt and Frizzled APC GSK3B LRP5 LRP6 PMC4437511__F4 Proteins from known pathways localized to the Trichomonas vaginalis hydrogensome FES FXN ISCU PMC3437941__F1 Integration of B cell responses through Toll-like receptors and antigen receptors BCR IRAK1 TRAF6 IRAK4 MYD88 PMC7753360__F2 Therapeutic targets and anticancer drugs within the lipid metabolism pathway VLDLR SCD LPL LDLR ACLY MTOR TG HMGCR CD36 PMC7753360__F1 Lipid metabolism overview in normal and cancer cells VLDLR LPL LDLR ACLY HMGCR PMC7847636__F3 Canonical Wnt signaling activates DPAGT1 expression and protein N-glycosylation, leading to extensive N-glycosylation of E-cadherin DPAGT1 LRP5 CTHRC1 PMC4894499__F3 Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury CYP3A4 SULT2A1 BAAT UGT1A1 PMC12111946__F3 Research Progress in Medical Biomaterials for Bone Infections TLR4 BCR MTOR PMC8076345__F3 Differentially Expressed Protein Interaction Network ACAD8 TIMM44 CNTN1 NAPB DNAJB1 HEL-S-26 USO1 RPS19 EIF3B PDHA1 ERLIN1 PGAM5 RAB8B DCC FIS1 MFF DBN1 PA2G4 PVALB GCLC SFRS5 TSC2 GABBR1 ABAT AIMP2 RPS6KA2 ENTPD2 ANK2 LARS2 PPFIA2 MARS2 VWA1 GADD45GIP1 NECAP1 RAB3GAP2 PRKCSH AKAP5 HEL-S-128m HECTD1 PNPT1 ALDH7A1 EPN1 BIN1 ASB14 HEL-S-70p NDUFB6 DCTN4 GNG5 RIN1 SAMM50 PADI2 PTPRF ARFGAP2 PSMD12 SNRPB ACADVL RAB5C HMGN2 VTI1A HERC2 MRPL14 ALDH3B1 HSPA2 MRPS2 PDPR EIF3G CYLD HEL-S-2 AMPD2 CALB1 SRC UFL1 ARHGAP5 ME3 CAPZB NDUFS8 PJA2 ELMO1 HEL-S-281 IMMT ME2 WASF1 RBCK1 GANAB CDK5 NRCAM CACNB3 EIF4E RAB6B SPTB YKT6 RPS13 PAK1 KHDRBS1 TRIM9 NDUFB7 HEL-75 CDH10 VCP HEL107 ADD1 PDIA4 SNRPG PTEN CACNA2D1 MIA3 HMGN1 EIF4B CCAR1 APOA2 SNAP91 PFAS ADD3 WASF3 RRAS ATP6V1D PCCA PFKL VAMP1 NAPA SIRPA SYNJ1 NDUFA2 DNAJB11 VAMP3 ATP6V1G1 CYC1 ECHS1 CYCS PMC7490904__F1 Physiological functions and regulation of the cyclin D-CDK4/6 complex TSC2 CDK2 CDK4 CDK6 PMC5468232__F12 ARF/p53 pathway CASP3 TSC2 PERP ATM MYC MDM2 PTEN ATR RFWD2 PMC5468232__F11 Estrogen signaling pathway CCIN DAO SHE TF PMC6080523__F4 Graphic scheme of pathways shared by genes found in network analysis for progressive motility PMC8615680__F1 Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability LIPC CAP1 MYLIP NPC1L1 PPP1R3B LPA ABCB11 MTTP SLC22A1 CYP7A1 PCSK9 LPL LDLR NPC2 DKFZp434B2017 APOE SORT1 GCKR NPC1 ANGPTL3 ABCG8 ABCG5 HNF1A HMGCR OSBPL7 LIPA ABCA1 LRPAP1 PMC7922891__F7 Hereditary disorder, metabolic disease, organismal injury and abnormalities network affected in lymphoblastoid cells derived from an SS patient TAS2R20 PRKRIP1 DENND1C PCIF1 QTMAN FAM50A DTWD1 NAA25 TCP11L2 SP140L DTD2 ZNF431 DCXR FMNL3 BRWD1 PMC7922891__F6 Graphical summary of human skin fibroblast profiling of SS patients OLR1 BMP2 GNA13 IL36G TICAM1 BMP4 PMC7118069__F1 Major signaling pathways for protective mechanisms against ASD by SF COX2 KEAP1 TNF HSF1 PMC8185703__F1 LZTR1: A promising adaptor of the CUL3 family F2 SHOC2 PMC12009291__F1 Glucose metabolism and lipid metabolism reprogramming in RCC FBP1 UQCRH TRIM21 PFKFB4 MLYCD EZH2 ECHS1 DEPDC1 HEL-S-5 PMC8185703__F2 LZTR1: A promising adaptor of the CUL3 family RIT1 NF1 RRAS HRAS PMC5911514__F2 Primary Cilia as a Signaling Platform for Control of Energy Metabolism SUFU APC SMO PMC5361837__F4 Examples of functional networks of regulated genes shared by different tissues RAB35 SMYD3 DST ALKBH3 PSAP OPTN NTN1 MRPL9 RPL39L PON3 PLA2G12A RPL3L SFXN4 CTSC SLC35B2 SLCO2B1 CLN3 TRIO PMC7718646__F1 miRNA-23a can enhance the metastasis and invasion of OS cells by upregulating the signal expression of PTEN signaling pathway ZNRF3 EGF BAD PRMT9 EGFR PTEN MTOR PMC8531546__F2 Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage SPHK1 RAC1 TNF NFATC3 PMC11263586__F5 HPV perturbs DNA damage response signalling pathway RAD17 ATM TOPBP1 HUS1 ATRIP MDC1 RAD50 RAD51 ATR H2AX PMC2699967__F2 Signaling pathways initiated by TLR-2 and TLR-4 activation TBK1 CD14 IRAK1 TRAF6 MYD88 MAL PMC6349186__F4 Wnt signalling pathway uniquely identified by ce‐Subpathway ROCK2 BAMBI INVS APC SOST CER1 SMAD4 SKP1 TCF7L2 ARHA FBXW11 NLK SIAH1 LEF1 EP300 CYC1 PMC6349186__F5 MI‐related subpathways where key nodes are annotated VASP BAD NGF HEL-S-28 SHE ARHA PTEN CRK IRS1 FRS2 GRB2 SRC BDNF CDC42 BAX PMC4094786__F4 Metabolic pathways for the production of the high-value products by using Z SDHC HBD HEL-S-133P PMC3647990__F9 Model for Rrp1 regulation of chitobiose metabolism in B RRP1 MAL PMC4659440__F5 c-Met as a Target for Personalized Therapy EGF HGF VGF EGFR MTOR PMC4659440__F3 HGF-MET signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NFKB) leading to increases in cell survival, motility and proliferation BAD HGF GSK3B MDM2 BCL2 MTOR PMC9267302__F6 Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages NPPA MAP2K4 ATF2 MYOCD LIF PTGS2 MAPK7 NPPB MAP3K7 RPS8 PRKD1 HEL-S-11 PIK3CA GNAS JUN PMC6824625__F9 Hypothetical schematic model for a novel oncogenic mechanism of G0S2 G0S2 MMP2 YAP1 MMP9 SRC LATS1 IL6 PMC3346111__F7 Overall scheme of hypothetical effect of endocannabinoid signaling in human melanocytes POMC MC1R TRPV1 PMC4828651__F4 Transcriptome Variability in Keratocystic Odontogenic Tumor Suggests Distinct Molecular Subtypes DKFZp686L0365 HHIP SUFU SHH ADRBK1 PMC9679292__F3 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke MAF GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 ATF4 ADA DMP1 TF PMC5423227__F1 Alterations in DNA methylation patterns as a source of cancer progression traits HEL-S-26 PDGFRA CTCF VHL VEGFA BCL2 CYTIP PMC9679292__F2 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke CTH FER GPX4 LPCAT3 FACL4 HEL-S-64p ADA HEL-75 GLS PMC3944322__F1 Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy TH GDNF NRTN PMC5827560__F1 A biological pathway regulating memory, synaptic plasticity and schizophrenia risk ERBB4 NAB2 ARC NRG1 BDNF NFATC3 PMC6567807__F1 Curcumin modulates cancer progression by controlling diverse signal transduction pathways BAD GSK3B UNK MTOR STAT3 BAX PMC3328216__F1 CCM3 interacts with multiple signaling complexes ROCK2 ROCK1 UNK ARHA PMC7464343__F2 The mechanisms and cell fate decisions’ crosstalk underlying necroptosis induction RIPK1 TRADD TRAF5 CYLD UNK RIPK3 TNF MAP3K7IP1 TRAF2 FADD MLKL PMC5593197__F6 Equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila RALA SMAD4 SMAD1 JUN PMC8075731__F7 HGF/c-Met signaling regulates early differentiation of placental trophoblast cells HGF CP PMC7761504__F1 Wnt signalling pathways DAAM1 APC LRP5 LRP6 ARHA RYK DKK1 JUN CDC42 PMC11432004__F4 PI3K/Akt/mTOR signaling pathway by O-GlcNAcylation TSC2 OGT PTEN IRS1 FASN PMC11432004__F3 Pathways associated with O-GlcNAcylation, thrombosis, inflammation, and cancer EGF HGF EGFR PTEN MTOR FLT3LG ERBB2 GRB2 KITLG CCND1 CDK4 FLT3 TGFA PMC8860906__F1 Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review FOXO4 ATG12 FOS SMO NAPA BCL6 PMC7379337__F7 Schematic illustrating the mechanisms involved in the protection of hyperoside against oxidative liver stress FYN PHLPP2 GSK3B PMC3956533__F7 Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells TSC2 TSC1 EIF4B PMC6909929__F1 Proposed model of myostatin-induced skeletal muscle wasting and insulin resistanceMyostatin binds to it’s receptor (ActR2B), phosphorylating the Smad2/3 pathway IGF1 SMAD2 SMAD4 MTOR IRS1 PMC5064167__F1 Upstream and downstream mechanisms of the ERK5 signaling cascade in DRG neuronsDashed lines indicate the need for further examination of possible signaling or the mechanism, which is complicated and abbreviated in this text NGF SRC BDNF MEF2C PMC3059306__F1 TSC mediated signaling in the central nervous system TSC2 RICTOR MTOR RHEB MLST8 PMC6548990__F2 TNFR1 signaling RIPK1 TRADD RIPK3 TRAF2 CASP8 FADD MLKL PMC6548990__F4 Cytotoxic TLR-TNF signaling network TRAF3 RIPK3 MYD88 TNF TLR3 RIPK1 TLR4 CYLD RELA TRAF2 CASP8 IL1B FADD MLKL PMC6548990__F3 TNFR2 signaling TRAF1 TRAF3 PMC6548990__F5 Type I interferons in the cytotoxic TLR-TNF signaling network TBK1 TANK STAT2 IRF9 TRAF3 RIPK3 IRF3 IFNAR2 MYD88 TNF IFNAR1 TLR3 STAT1 RIPK1 TLR4 RELA TYK2 JAK1 IRF-1 MLKL PMC8377849__F10 Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation PROP1 NODAL LHX3 PMC3133224__F9 Molecular interplay between FBXL2, its substrate CCTA, and CaM controls phosphatidylcholine (PC) synthesis UBC SKP1 PMC6787465__F1 Schematic outline of major Btk signalling cascades TRAF6 IRF3 PLCG2 MYD88 TLR3 NLRP3 BTK IL16 BCR BASH BIK LYN SYK CD19 MAL PMC5063375__F4 Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency TH PMC9623986__F3 Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data PIN1 PALB2 CCNA2 PLK1 BRAF MAPK3 MAPK14 RCHY1 TCF20 MAPK1 RAD52 CDC2 ARAF UBE4B CCNE2 PLK3 RPS6KA5 CDK5 FGFR3 MAP2K2 HRAS CHEK1 DAPK2 RASSF1 EP300 MAP2K1 BRCA2 CDK2 TP73 CIDEA WWOX ITCH PMC3494587__F12 Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes EIF2S1 PI3 ATG12 MAPK8 EDEM1 ATF4 BCL2 EIF2AK4 XBP1 PMC4332478__F3 Integrative Multi-omics Module Network Inference with Lemon-Tree KLLN PDGFRA DKFZp781B1423 EGFR FGFR3 PTEN RB1 CDKN2A INSR CCNE1 CDKN2B KRIT1 MDM2 CDK4 PMC7388972__F5 Schematic representation of S. pombe cell wall integrity pathway PCK1 ATF1 PCK2 PMC6129528__F4 Regulation of cell signaling pathways involved in cancers by KDM2B EZH2 MTOR PMC6129528__F6 Overview of KDM2B mediated molecular mechanisms in cancer development NSG2 MYC KDM5A PMC10898159__F3 Mechanism of action of existing drugs targeting KIT expression and mutations KIT PTCH2 AMPD3 PTCH1 FGF2 FGFR3 SMO SP1 CDK7 CBL BRD4 PMC4145906__F3 The role of mitochondria in Parkinson's disease LRRK2 POLG TFAM PMC7513951__F3 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment GSK3B MYC CCND1 TCF4 PMC5596544__F8 Schematic of the AcSDKP/FGFR1/MAP4K4 pathway suppression of TGFB/smad signaling and EndMT FGFR1 FRS2 TGFBR1 TGFBR2 HEL-S-31 PMC9338018__F1 MiR-30a-centered molecular crosstalk regulates Th17 differentiation IL21R TLR4 RELA INPP4B PMC7513951__F2 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment EGFR GRB2 SRC MTOR PMC11641392__F2 Notch signaling pathway with Notch and Bcl-2 therapeutic targets in T-ALL PTMS BAD BCL2A1 ADAM10 FURIN MCL1 PMC7158685__F1 Main immunological pathways in human antigen presenting cells (APCs) after mycobacterial RNA recognition TLR8 APC IRF3 MYD88 IL1B TLR3 IFNG PMC4052302__F10 General overview of TLR4 signaling in humans TANK TLR4 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAL PMC4300671__F1 Working model for rotavirus cell entry into MA104 cells M6PR EEA1 ARHA ACTN4 CDC42 PMC5796392__F6 Role of miRNA in the antigen cross presentation pathway STAT1 HEL-S-269 PSMB9 HEL-S-72p PSMB10 PSMB8 PMC11223907__F1 Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics CYP2C9 CYP2C19 CYP3A4 PMC5613881__F2 Regulation and signaling crosstalk of the Hippo pathway APC LATS1 RHO LATS2 PMC10898159__F2 Regulations in KIT protein and signaling pathway KIT PTCH2 AMPD3 PTCH1 FGF2 LIX1 FGFR3 SMO LMTK3 PMC10898159__F1 Gene and epigenetic regulations of KIT expression in GIST KIT BIRC5 CTCF HAND1 HIC1 FOXF1 BRD4 PMC3430207__F3 Molecular relational network of genes modulated by BaP in lung tissues enriched for cancer function using IPA for all three doses with p53 at the central node TNFRSF12A MYC BCL2L1 SAA1 MMP3 FBLN5 TP53INP1 DCN PERP EPX CCL24 MDM2 SHH ANGPT2 AKAP12 ACTG2 PLAUR LTB LCN2 LAMB3 HEL-S-31 CDKN1A CDKN2B CCNG1 IGFBP2 PRKCH BDNF TPM1 HEL-S-101 INS LTC4S HEL-S-14 RHOU PDGFD CFD RRM1 BASH GDF15 F3 PLCE1 IL1RL1 CCND1 KITLG HMGN1 IL1B BAX ITGA1 HEL-S-89n CD47 NOTCH4 PLK2 PDGFRA CD200 IGFBP5 TNFSF10 RELA PMAIP1 EPHA2 LMO2 PMC5613881__F1 A brief summary of the intracellular Hippo pathway in mammals LATS1 LATS2 PMC8909069__F3 Biomarkers in FLT3 AML GRB2 MTOR PMC6952906__F2 Schemes of feedforward loops (FFLs) EGR1 SCAMP3 IL6 RB1 PPARG TF PMC7395767__F1 Old dogs, new trick: classic cancer therapies activate cGAS TBK1 CGAS IRF3 PMC6462526__F6 5′-IT treatment affects intra-/extracellular adenosine balance and INSM1 expression leading to NB tumor cell death GSK3B INSM1 ADA CCND1 ADK PMC4556939__F4 Transcriptomic analysis of cyclic AMP response in bovine cumulus cells PDGFRA PGR PCK1 MMP9 VCAN VEGFA HIF1A HAS2 FGFR2 PTX3 CCK PLAT SMARCA4 FGFR1 CDKN1A GJA1 LDLR MAP3K8 NOS2 YWHAG STAR STAT3 PMC4556939__F7 Proposed pathway of cAMP signaling after FID addition during in vitro maturation CCK AREG EGFR HAS2 STAR HK2 PMC5503519__F9 Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells IL13RA1 JAK1 CCND3 GATA3 PMC9573978__F2 Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis APC GSK3B LRP5 LRP6 PMC4199747__F6 PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status DAPK2 CIDEC STAT3 PMC3547332__F5 MicroRNA involvement in the inflammation, innate immunity, and oxidative stress pathways in AD and cancer CFH IRAK1 IRAK2 TRAF6 PMC3481480__F11 Pathway Diagram of Oxidative Stress along with PI3k/Akt MAF BAD KEAP1 ATM GSK3B MDM2 PTEN BACH1 PMC8255023__F4 Aberrantly methylated-differentially genes and pathways among Iranian patients with colorectal cancer BAMBI NLK INVS STOM APC NOTUM SOST LRP5 LRP6 SKP1 ARHA PMC6354055__F1 Mutation Hotspots in the Beta-Catenin Gene: Lessons from the Human Cancer Genome Databases LEF1 APC GSK3B PMC9550596__F5 Henipaviruses: an expanding global public health concern? STAT1 TLR8 TLR7 STAT2 IRF7 IRF3 IFNAR1 TRIM25 TLR3 MAVS PMC6305535__F5 Representation illustrating the interactions of Fusobacterium nucleatum in colorectal cancer TLR4 MYD88 IL1B PMC4687939__F6 Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism CTBP2 RBP1 NFATC4 PLIN1 EBP CTBP1 HIF1A FOXC2 HEL-S-104 DKFZp686F0183 XBP1 FBXW7 CEBPB SOX9 MNAT1 LPIN1 MSC BSCL2 LPL PER2 SETDB1 BMP2 KLF5 KLF3 LEP EGR2 TXNIP PMC7092482__F1 Epigenetic modulation of noncoding RNAs regulate cancer biology AGO2 SOX2 EGFR ALKBH5 PMC8817562__F1 Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy APC GSK3B STAT3 PMC7590900__F1 CXCR3 signaling pathways in different cell types CXCR3 INA DERA CXCL10 CXCL9 CAD CXCL11 PMC4267650__F6 The roles of the RuvBL1-RuvBL2 complex in regulating the FA DNA repair pathway RUVBL2 GIG8 ATM RUVBL1 SMG1 TRRAP MTOR ATR PMC6964678__F3 Lipid metabolism by PI3K–mTOR signalling TSC2 TSC1 NADK GSK3B SRPK2 ACSS2 PTEN ACLY FBXW7 SGK1 RHEB FASN PMC6964678__F2 Cancer cells obtain fatty acids (FAs) from de novo lipogenesis and exogenous uptake HEL-S-26 FADS2 SCD GLS2 ACSS2 ACLY CD36 PMC3694595__F1 IL-33: A Novel Danger Signal System in Atopic Dermatitis IL33 IL25 TSLP PMC4918232__F2 B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292 BTK BCR LYN SYK MTOR CD79A PMC4918232__F1 Antigenic stimulation of the BCR recruits CD79a and CD79b, and activates SYK and LYN kinase, resulting in the phosphorylation of cytoplasmic ITAMs on the immunoglobulin domains of the receptor BTK BCR LYN SYK CCL4 MTOR CCL3 PMC4929790__F2A Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy MPO CTSS CSF2RB HEL-S-104 RPSA CEBPD HIVEP1 PRSS2 GBP2 F3 THBS1 IRF-1 NCOR2 ARHGDIB ANGPT2 ANXA1 IRF7 FOS LCN2 IL8RB MGST3 TNF CYTIP NFKBIA VCAM1 ARC TXNIP PMC2824626__F1 Pathway for cholesterol synthesis from 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) by HMG CoA reductase and its inhibition by statins BMP2 ARHA RAC1 CDC42 PMC5577206__F2 Vascular endothelial growth factor-B in metabolic homoeostasis: current evidence NRP1 VEGFA VEGFB PMC4598984__F1 Data analysis of the identified Snf1 interactors CPA2 tal-1 RPL3 PMC11871796__F2 The possible mechanism leading to Tourette syndrome (TS) associated with the immune response/inflammation IL6 TNF STAT3 PMC11871796__F1 Microglia M1 polarization–mediated tic onset TH CCR5 SOCS3 NLRP1 PITX3 MYC CCL5 CCL2 HMOX1 CCR1 PMC3661948__F2 Receptor-mediated regulation of KATP channels MC4R LEPR INSR PMC5078009__F4 Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells SOX2 EPCAM MTOR PMC12162393__F9 Diagram of potential mechanism of TPX2 in HCC HCTP4 MTOR PMC7485276__F2 Illustration of selective components in the BMP signaling pathway, important for bone and cartilage formation and fracture healing SMAD4 SMAD1 DKFZp781O1323 PMC4523214__F1 Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma BTK BCR LYN GSK3B MDM2 SYK PLCG2 PTEN MTOR CD19 PMC7846844__F8 LincRNAs involvement in muscle fiber hypertrophy signaling by regulating its target genes IGF1R PC IGF1 IGF2 MCU PMC8946552__F2 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications FLCN EPO PBRM1 HGF KEAP1 EGFR PTEN HMOX1 CDKN2A CDK6 FH FNIP2 CDK4 SDHD SDHA SDHB BAP1 SDHC FES RBX1 RHEB TSC2 TSC1 TFEB CDKN2B FNIP1 PMC8946552__F4 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications GPX4 LPCAT3 FACL4 DHFR PMC9214809__F8 Selective PPARD agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway FGF21 NR1C2 CYP7A1 PMC11868049__F2 Downstream effects of the ubiquitination process in the cGAS-STING pathway TBK1 TRIM13 CGAS USP21 TRAF6 IRF3 BAX PMC11868049__F1 Ubiquitination in cellular processes of cGAS-STING Pathway TRIM41 TBK1 CGAS USP21 SPSB3 IRF3 PMC7080318__F7 LINE-1-induced replication stress RADX RAD1 FANCD2 BLM HUS1 ATRIP RFWD3 ATR WRN PCNA PMC7352172__F2 Activation of the NMRK2 pathway represent a common adaptive mechanism in the failing heart where NAD+ levels are low NAMPT NMRK2 NR1C1 PMC7352172__F1 NAD+synthesis pathways NAMPT NRK PMC8122392__F2 Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Signaling, Tumorigenesis and Metastasis MYB CD151 APC CD82 RELA MYC LRP5 CCND1 LRP6 CD36 PMC4698020__F8 Schematic diagram showing the inhibitory effects of triptolide on oxaliplatin induced upregulation of nucleotide excision repair pathway XPC ERCC1 XPA PMC5882534__F2 Optogenetically controlled protein kinases for regulation of cellular signaling BAD BAX PMC7418174__F1 Diagram showing mTORC1 and mTORC2 signaling pathways TSC2 ULK1 TSC1 TFEB RPS6 DEPTOR IRS1 RHEB PMC9279477__F2 Calculated excited states of Pd-DPAphos complexes and synthesis of DPAsphox (1) SET SOS2 SOS1 PMC5826840__F8 Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway And Aggravates Hepatocellular Damage In Mouse Ischemic Livers CASP3 TLR4 ROCK1 UNK NOTCH1 TRAF6 PTEN MYD88 HES1 PMC11694134__F4 RAS pathway activation and downstream effects in chronic myelomonocytic leukemia PLK1 SOS2 AURKA CDK6 RHEB CBL TSC2 NF1 TSC1 WEE1 PTPN11 GRB2 CCND1 CDK4 CDC2 SOS1 PMC11694134__F5 Additional established and investigational therapeutic targets in chronic myelomonocytic leukemia NLRP3 PDC HOXA9 LILRB4 BCL2 IL1B TET2 BRD4 PMC9325157__F2 Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19 TBK1 TANK STAT2 IRF9 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 JAK1 ACE2 MAVS PMC7555177__F5 Sphingolipid signaling pathway and sphingolipid metabolism PIK3R1 PRKCZ GLB1 SGPP1 PTEN RHO S1PR4 GBA2 PRKCA FYN ACER3 CERK BAX ROCK2 CER1 S1PR1 S1PR3 TNF HEL-S-130P GNA11 NSMAF MAP2K1 UGCG GAB2 BDKRB2 SPHK1 PIK3R2 PMC7555177__F4 Protein–protein interaction networks of the encoded proteins of the consistent DEGs that participate in sphingolipid signaling pathway (hsa04071) and sphingolipid metabolism (hsa00600) PIK3CD PIK3R1 PRKCZ GLB1 SMPD2 PPP2R2C GBA2 PDPK1 PRKCA FYN MAPK1 MS4A2 ROCK2 PPP2R3C HRAS PIK3R3 PLCB1 NSMAF RAC3 UGCG PPP2R5C SGPL1 BCL2 BDKRB2 SPHK1 PPP2R5B MAPK11 DEGS2 AKT3 PRKCE S1PR2 SGPP1 ROCK1 PTEN PLD2 ACER3 CERK PPP2R2A GLA BAX SPTLC1 HEL-S-130P SMPD4 MAP2K1 SGMS1 PIK3CA SPTLC2 SMPD1 RAF1 PIK3R2 PMC8569372__F6 Alternative splicing in human cancer progression PTBP1 NEK2 PMC6959052__F7 Working model of the role of IL-6/STAT3 pathway on hypoxia promoting HCC progression after TACE SNAI1 ELL STAT3 PMC8699390__F3 Of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges TRIM21 RELB TRAF6 TRIM8 TRIM6 TRIM4 TRIM25 TRIM23 TRIM40 TRIM13 TRIM14 TRIM52 TRIM38 TRIM32 TRIM56 TRIM5 TRIM37 ITCH PMC3656004__F11 Acetylcholine Promotes Ca2+and NO-Oscillations in Adipocytes Implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ Positive Feedback Loop - Modulatory Effects of Norepinephrine and Atrial Natriuretic Peptide TRPC6 TRPC3 PTEN PMC3348393__F1 Cellular Senescence and Cancer Chemotherapy Resistance ATM MDC1 ATR H2AX BRCA1 PMC8621778__F1 Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases DAAM1 APC GSK3B LRP5 LRP6 ARHA RYK VANGL1 PMC9688300__F1 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease OGA PCK1 OGT CRTC2 PMC7103590__F8 Expression profiles and prognostic significance of WNT family members in glioma via bioinformatic analysis ROCK2 BAMBI EGF INVS APC SOST CER1 SMAD4 SHE SKP1 RYK ARHA PTEN MTOR NLK SIAH1 MDM2 ELL PMC9688300__F3 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease TFF2 OGT RIPK3 XBP1 PMC9688300__F2 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease GSK3B IRS1 PMC2584165__F2 Highly simplified diagram of signaling pathways involving Beta-catenin that may be relevant for RPE cell morphogenesis and susceptibility to age-related oxidative stress APC LRP5 TYRP1 LRP6 CDH2 PMC8781927__F6 FGFC1 Exhibits Anti-Cancer Activity via Inhibiting NFKB Signaling Pathway in EGFR-Mutant NSCLC Cells CCND1 CDK4 TNF PMC7317222__F6 Cholesterol-oxysterol metabolic pathway TH CH25H CYP46A1 PMC1297683__F3 Final network resulting from applications of our integration method to the 18 types of evidence for yeast galactose utilization and a set of network analysis tools MALL LAP3 PMC2746948__F1 Apoptosis pathway APAF1 FADD PMC6235681__F2 Details of the SHH and Akt pathways SUFU PAWR PTCH1 SHH SMO MTOR PMC3184252__F6 Pathways of androgen biosynthesis STS HSD17B2 HSD17B3 RDH5 AKR1C2 CYP17A1 HSD17B10 PMC6208163__F6 The Roles of NRF2 in Modulating Cellular Iron Homeostasis MAF GPX4 FTH1 SLC7A11 MT1G FTL HMOX1 PMC2212135__F6 Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2 IGF1R UCP1 IGF2 PRLR IGF2R PMC7135884__F3 Metabolic adaptations after phagocytosis and inflammatory stimulation in macrophages and microglia IL16 MTOR IL1B PMC6208163__F2 Roles of NRF2 in Modulating Cellular Iron Homeostasis MAF ABCB6 FECH PMC10779880__F4 Mechanisms of treatment of neurodegenerative diseases (NDs) using capsaicin and N-oleoyldopamin (OLDA) CNTF FAAH MTOR TRPV1 PMC4179759__F1 Melanoma signaling pathway BRAF NRAS PTEN PMC7477441__F7 Mechanism of LINC00355:8 in HCC CDH2 WNT10B PMC3797167__F7 Illustration of the proposed mechanisms underlying the crosstalk between insulin/IGF1 and IL-17 signaling pathways CXCL1 IGF1 TRAF5 GSK3B CCL20 TRAF6 TRAF2 IL17RC PMC6874469__F5 ERB/Ptgds signalling pathway imbalance disrupting renal lipid metabolism and continues influencing ‘hypothalamus-uterus-kidney axis’ (HUK axis) function AMBP PMC5419340__F2 Diet supplies nicotinamide, nicotinic acid, and nicotinamide riboside as well as the essential amino acid tryptophan NAPRT NAMPT NNMT PMC5916231__F1 Heme synthesis pathway FECH AIP UROS HMBS CPOX PMC6557297__F4 Possible replication-coupled ICL repair mechanisms NEIL3 BLM FANCM TRAIP PMC2600462__F5 Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions TSC2 EGFR EIF4E MTOR RHEB SKP2 PMC11615404__F10 Fisetin on ferroptosis and oxidative stress in glutamate- and erastin-stimulated HT22 cells and rats after TBI, which may involve the PI3K/AKT/NRF2 pathway GPX4 STEAP3 FTL SLC3A2 PMC3097389__F1 CoQ10 biosynthesis pathway COQ3 COQ2 COQ6 COQ5 PDSS1 COQ7 PMC3497051__F4 Autophagy process ULK1 ATG12 ATG3 ATG10 MTOR DKFZp686F0183 PMC8570279__F1 Transcriptional Control of Metastasis by Integrated Stress Response Signaling KEAP1 ATF4 EIF2A ATF3 PMC2820251__F1 Innate immune evasion strategies of influenza viruses TBK1 TANK TRAF3 TRAF6 IRF3 TRIM25 MAVS PMC9252739__F1 Shiny GATOM: omics-based identification of regulated metabolic modules in atom transition networks NAMPT ENPP1 HEL-S-30 OXCT1 ENO1 UMPS MGST3 HEL60 HEL-S-26 GOT2 RRM1 PNPLA7 HEL-S-64p RPIA KHK ACLY SUCLG2 HEL107 ASS1 MECR PGAM1 pcap PMC5095918__F5 LUBAC and UBE2L3 regulate NFKB response UBE2L3 SHARPIN TNF IL1B PMC7483931__F1 Periodontal disease associated genes and proteins have multiple possible interactions with GM-CSF and TSLP POSTN PTGS2 ODAM HYAL3 TNFSF13 HYAL4 CXCL12 TNLG7A DGKA PMC7917312__F2 Armed oHSVs for GBM treatment EIF2A ULBP3 KLRG1 IFNG PMC3445623__F2 Gene Expression and Functional Annotation of the Human Ciliary Body Epithelia HDAC3 PELP1 GRIP1 TBP PGR IGFBP1 GRB2 NR0B2 SRC PMC4866511__F7 Endosomal System Genetics and Autism Spectrum Disorders: A Literature Review TSC2 TSC1 PTEN RHEB PMC7923825__F1 Engineered (S)-linalool biosynthetic pathway in P MVD MVK IPP PMC6032036__F4 Ingenuity pathway analysis of ALX4 genes and antidepressant genes based on treatment response in MDD TPH1 IL5RA PLG EXT2 GAS7 MYC ALX4 CYP2E1 CYP7A1 LEF1 CYP2C9 CYP4F12 CYP2U1 HTR2A BDNF PMC7363449__F1 Acute Kidney Injury and Maladaptive Tubular Repair Leading to Renal Fibrosis RIPK1 MYD88 ATR PMC4673612__F6 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks ASAP1 EGF PRKCZ PEAR1 BRAF HEL-S-1 MYC MAPK14 RALA CEBPB PDPK1 PRKCA SH3GL3 EPN1 PLCE1 TNP1 SP1 RFXANK PRKCI CEBPA RALB HRAS HDAC1 GRB7 SPRY2 FLOT2 SH2D2A SH3GL2 WASL GJA1 NFKB1 RELA CTNND1 JUND JAK1 HEL-S-93 PXN PMC8870348__F3 Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy DHODH DCC NDP PMC4673612__F4 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks BTRC ROCK1 ATF2 MAPK14 STAMBPL1 TRAF6 MAP2K3 DKFZp686L0365 NR1i1 HGS UBE2I FOSB CCND1 JUNB PRKAR1B SKI TGFBR3 FNTA PARD3 ANAPC2 CD44 ATF3 ARHA SMURF1 CRK BRCA1 CREBBP HNF4A COPS5 SMURF2 GRB2 TGIF1 JUND SOS1 MEF2C PMC4673612__F7 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks PIN1 BTRC WNT1 WNT7A SOX1 RYK DKK1 CDK6 DKFZp686L0365 PRKCA JUP WNT4 CCND1 ROR2 CSNK1A1 CDH2 AXIN2 HEL-S-28 APC ARHA RAC1 FZD4 WNT3 DAAM1 PRKCB WNT3A PPP2CA hCG_2014051 DIXDC1 TCF4 PMC11830176__F1 HBME inhibit LPS activated canonical NF-kB pathway in microglia and its effectors NLRP3 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC4911209__F1 Complete vs ZEB2 PMC5095918__F2 The Fanconi anaemia pathway REV1 F10 BRCA2 PMC2820251__F2 Innate immune evasion strategies of influenza viruses STAT1 ISG15 STAT2 TYK2 JAK1 PMC3337981__F8 BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NFKB pathway BCL10 BCR AID TRAF3 RELB TRAF6 CD40 MYD88 TRAF2 PMC5559228__F4 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways PREB FNIP1 MTOR PMC7554788__F1 Action of CDK4/6 inhibitors CDK4 MTOR CDK6 PMC5727316__F1 lncRNAs in Wnt/B‐catenin signalling APC GSK3A PMC5559228__F2 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways ULK1 PTEN MTOR RHEB TSC2 BTK RICTOR TSC1 FNIP2 LYN GRB2 FNIP1 SYK CD19 PMC4263855__F3 Potential protective role of O-GlcNAcylation within the healthy brain, which may become deficient in the AD brain OGA OGT APP PMC10304117__F1 ASFV proteins modulating the cGAS/STING and NFKB signaling pathway (Created with BioRender TBK1 CGAS IRF9 IRF3 RNF128 PMC9243614__F3 Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs, biological pathways and genes involved in the molecular pathogenesis IKBKB NFKBIA CHUK IGF1R IGF1 NFKB1 IGFBP1 IGFBP4 REL IGFBP5 IL1B PMC6415732__F2 Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities ULK1 OMP ATM ATG101 RHEB BAX PMC5115891__F3 Comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1 HES7 MTOR JUN HES1 PMC3797025__F7 Schematic model of adaptive primary resistant responses by tumors to anti–IGF-1R monoclonal antibodies (mAbs) IGF1R EGFR SRC MTOR PMC3387494__F3 The regulatory network of EZH2 SET CDK2 EZH2 CCNE1 PMC3026729__F7 Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice CACNA1G BMP2 TBX2 TBX5 SCN5A GATA4 HCN4 PMC11821632__F1 Canonical and non-canonical TGFB signalling pathways SMAD2 TGFBR1 MAP3K7 SMAD4 TRAF6 MTOR TF TRAF4 PMC8628126__F2 SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases ROCK2 ROCK1 ATF1 CREB1 ARHA IL6 CTNNA1 RHO MAP2K3 HMGA1 NELFE HEL-S-102 STAT1 PAK1 MAP4 IL2 HDAC2 HMGN1 HEL113 CSNK2B MAP6 CDC42 PMC9353242__F2 Hedgehog signaling regulates the development and treatment of glioblastoma NEU4 QK3 SMO GSC DLG5 PMC7563227__F2 Roles of PGs in hormone-dependent cancer metastasis CS SDC1 CCL20 SRC IL8RB LRP6 STAT3 PMC4888354__F3 The mechanisms of action of ANG Secreted ANG undergoes receptor-mediated endocytosis from the cell surface to the inside of the cell where it accumulates in the nucleoli under growth conditions or in the cytoplasm under stress conditions PLSCR1 PLN FST MDM2 PMC5557313__F1 Illustration of the complement activation pathway with annotations for quantified glomerular proteins in progressive versus non-progressive IgAN patients HEL-S-62p CFHR3 C4B_2 CFHR5 CR1 CD59 CFHR2 C9 VTN CRP C7 C6 C1S CFHR1 PMC8394119__F1 NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis HEL-S-44 SIRT1 IFNG SIRT3 PMC6142327__F3 Role of AMPK signalling pathway during compensatory growth in pigs RUNX2 CD6 KRT18 PMC6109777__F4 Cellular protection mechanism conferred by Nrf2-ARE pathway after intracerebral hemorrhage (ICH) MAF KEAP1 NQO1 BACH1 PMC12191222__F3 Top2b-regulated gene, Ubb, is a key player in protein degradation and transcriptional regulation in the retina UBC UBB PMC2703816__F3 Identification of neuronal target genes for CCAAT/Enhancer Binding Proteins CD47 OCEL1 EGFR FNBP1 GHRHR CEBPA MSH2 UBB BRCA1 CDC42 PMC12191222__F2 Top2b-regulated gene, Bbs7, is an essential protein for BBSome-mediated ciliary trafficking RAB3IP LZTFL1 PMC12191222__F5 Top2b-regulated gene, Cetn2, maintains photoreceptor ciliary structure and function CETN2 PLK1 HEL-S-296 CETN3 PMC5777730__F8 Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer FHL1 MAP3K11 IRF9 GFAP ARHA GYS1 MTOR HRAS STAT1 PIK3R5 CREBBP GNAT2 SPIB PTPN11 GRB2 STAM2 PTPN6 RAF1 JAK1 RPL10 SLC26A3 NCF1 PMC12191222__F4 Top2b-regulated gene, Rbp4, is crucial for retinoid transport and visual cycle RBP4 RPE PMC11855151__F10 Chemokine signaling pathway (KEGG: hsa04062) illustrates gene regulation differences between AF and EU prostate cancer patients, highlighting the influence of lncRNAs identified through structural equivalence analysis BAD FLG SHE F11 ARHA SNAP25 DOCK2 CDC42 PMC4818686__F4 Rho Family GTPase signaling pathway alterations in adenoid cystic carcinoma GFAP RHO CYFIP1 PMC5377334__F3 Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133 GEM MYC TFAP2A SP1 TF RXRA PMC2874116__F2 Intrinsic pathway is deregulated in cancer BAD EGFR BAX PMC3652812__F4 Thymidylate Synthase Expression Determines Pemetrexed Targets and Resistance Development in Tumour Cells DHFR MTOR BAX PMC4686057__F4 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators MERP1 ADAM12 ITGA7 CIT ADAM19 PLXNC1 MAF LIMCH1 CDCA7 DSG2 SLC1A2 LEPR SEL1L3 FGD6 LRRC8C CPNE8 MAB21L1 NT5E OSBPL8 PCDH10 NUAK1 MMD ABI3BP MFAP3L SLC38A1 NREP RAB39B SDK2 PRUNE2 IKZF2 NTNG1 PMC8452875__F7 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease SIRT1 PMC9512240__F4 Radiation-induced Cell Death and Its Mechanisms NLRP3 GPX4 SLC7A11 SLC3A2 PMC3165008__F1 An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis SIT1 HEL-S-15 HMX1 PMC4686057__F1 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators ITGA1 COL4A4 CD47 COL3A1 CD44 LAMB3 ITGA7 COL1A1 COL5A2 LAMA3 ITGA2 COL4A6 LAMB1 COL4A3 THBS2 THBS3 COL1A2 COL6A1 THBS1 COL6A6 LAMC2 COL4A2 COL4A1 COL4A5 PMC9512240__F1 Radiation-induced Cell Death and Its Mechanisms RAC1 CYCS CDC42 PMC8541427__F4 Genetics of Diabetes: What We Can Learn from Drosophila TSC2 TSC1 PTEN RHEB PMC8541427__F2 Genetics of Diabetes: What We Can Learn from Drosophila PTEN TBC1D4 PMC3277713__F1 A schematic diagram of different components making up the interleukin-23 (IL-23) and IL-12 receptors and the common signal transduction and activator of transcription 4 (STAT4) activation pathway STAT4 TYK2 IL23R IL12RB1 PMC8452875__F1 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease CRY1 DBP AVP NFIL3 VIP PMC3684430__F1 Apoptotic pathways regulated by the UPR ATF4 EIF2A BCL2 ERO1A TRAF2 BAX PMC5538425__F1 Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy CD14 TLR4 TLR9 CSK SYK TLR1 PMC11506434__F6 NPS-1034-targeted pathways in RCC TNFRSF1A GADD45A AXL PMC8763273__F4 Upregulation of T Cell Receptor Signaling Pathway Components in Gestational Diabetes Mellitus Patients: Joint Analysis of mRNA and circRNA Expression Profiles NFKBIA AGA LCK ZAP70 IL6 EIF4A3 TNF PMC8667725__F4 Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities TLR4 PLG ADAMTS13 VWF LPA ACE2 TF PMC8463986__F1 Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome GSK3B APP MTOR IRS1 SIRT1 PMC7595734__F3 Lipid scavenging by extracellular arthropod-borne pathogens PC LPL PMC8216348__F9 Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways PTGS2 VEGFA ADRB2 IL6 ABCC2 GLA SELE PMC6855178__F1 Action of Targeted Therapies in Metastatic Renal Cell Carcinoma RET HGF VHL MTOR AXL PMC11654217__F4 Mechanistic overview of targeting PD-1/PD-L1 by bioactive natural compounds MUC1 STAT1 EGFR SYK TNF MTOR STAT3 PMC11654217__F1 Proposed signaling pathway representing PD-1, PD-L1, and their interactions MUC1 STAT1 EGF WNT3A EGFR TNF MTOR PMC8581865__F6 Dura cells in the etiopathogenesis of Crouzon syndrome: the effects of FGFR2 mutations in the dura cells on the proliferation of osteoblasts through the hippo/YAP mediated transcriptional regulation pathway LATS1 LATS2 PMC6360698__F2 Molecular signaling of inflammatory pathways involved in structural remodeling TBK1 CD14 TRADD SMAD2 SMAD6 SMAD4 TRAF6 IRAK4 IRF3 MYD88 MTOR TLR4 SMAD1 FADD PMC3590793__F1 ATR barrier to replication-born DNA damage RAD17 TOPBP1 ATRIP ATR PMC12191222__F7 Top2b-regulated gene, Crx, is a master regulator of photoreceptor development and maintenance CRX NRL NR2E3 OTX2 PMC12191222__F6 Top2b-regulated gene, Pik3r1, represents a pivotal signaling cascade in photoreceptor cells PIK3R1 PI3 PTEN MTMR4 PMC7456566__F3 Rhabdomyosarcoma IGF1R PLK1 ERBB2 PDGFA MDM2 CCND1 CDK4 FGFR4 MTOR CDKN2A FOXO1 MYOD1 PMC11654217__F5 Impact of natural compounds targeting PD-1/PD-L1 on various signaling pathways GPX4 SRC PTEN PMC11889221__F4 Metabolic differences between M1 and M2 macrophages PIG59 PMC11889221__F6 Tissue Macrophages in Diseases LRRK2 ATM CXCL10 opn APP CCL5 TNFSF12 CCL4 CCL2 CCL3 PMC6554685__F9 Cell Cycle and TGF-beta-Signaling Pathway Regulated by the E2F Alteration in Breast CancerThe (A) cell cycle and (B) TGF-beta-signaling pathway regulated by the E2F alteration in breast cancer (cBioPortal) are shown BAMBI NODAL SMAD2 TGFBR1 SMAD4 SKP1 ARHA STAG1 DBF4 CDC45 IFNG FST CDC20 CDK2 MDM2 THBS1 RAD21 PCNA SKP2 PMC10255599__F3 Anti-oxidant and anti-thrombotic activity of Vitamin D and Resveratrol in COVID-19 SERPINC1 NLRP3 HMGB1 NR1i1 PMC10255599__F2 Vitamin D and resveratrol immune response against SARS-CoV-2 infection NLRP3 TANK NR1i1 EBP SIRT1 CYP27B1 STAT3 PMC7719781__F5 Mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) regulates ER stress and insulin signaling VAPB MFN2 PMC4036287__F9 Working model for Fas signaling in cancer-related inflammation and breast cancer progression CS TES FADD PMC6762062__F1 Inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis LTB PMC2908618__F7 Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis MAPKAPK2 CXCR4 PDK2 CXCL12 MTOR PMC3741506__F1 ASC-mediated switch between pyroptosis and apoptosis: intracellular pathogens and their products lead to activation of the ASC-dependent inflammasome CASP3 NLRP3 CASP9 AIM2 CASP8 IL1B BAX PMC4833425__F6 Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGFB Signaling Pathway GHSR IL13RA2 IL13 TRAF6 TNF TGFB1 PMC6320700__F1 Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era CERS3 LASS1 DES CERS5 CERS2 CERS6 PMC2891586__F3 Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks NUMB GSK3B JAG2 LFNG SMAD4 MFNG RBPJL DLL3 HES1 HES5 DTX3L DLL4 DVL2 MAML1 PSEN2 DTX1 DTX2 DTX3 DTX4 DVL3 DVL1 EP300 PSEN1 NFKB1 PSENEN ITCH PMC5445378__F1 EGF-R and TGFB signaling pathways interfered by E5 SMAD2 EGFR SMAD4 PMC5445378__F3 Interferon synthesis and signaling pathways STAT1 STAT2 ATF2 IRF3 IFNGR2 TYK2 IFNAR1 IFNGR1 PMC5445378__F2 E5 immune evasion mechanisms COX2 EGFR HEL-S-92n BAX PMC5908975__F7 FAK/paxillin/AKT signaling pathway SOX2 MMP2 MMP9 CCND1 PMC4565673__F1 How to Turn On an Ancient Metabolic Enzyme? Add Insulin and Deacetylate HDAC3 MTOR HEL-S-68p PMC11545938__F1 Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases S1PR2 S1PR1 S1PR3 S1PR4 SPHK2 PMC9240646__F7 Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases FADS3 SPTLC1 ALOXE3 SSB DEGS1 ALOX12B DEGS2 SDR9C7 PMC7153006__F12 Schematic diagram depicting the cytoprotective effects of Kaji-ichigoside F1 and Rosamultin on hypoxia-induced apoptosis of EA.hy926 endothelial cells BAD BCL2 BAX PMC9338646__F1 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment NAMPT NADK MMP9 SHE SIRT3 NAPRT SIRT7 HEL-S-90n SIRT4 SIRT5 SIRT6 CD7 SIRT1 PMC4123363__F2 The p38A/ERK cross-talk in colorectal cancer SIRT1 BAX PMC7451565__F5 Genome-wide association study for mammary structure in Canadian Angus cows ARPC2 CNTN1 PNKD GPBAR1 PTPRE DLX5 PCSK5 PENK PPARG ART1 GPR139 PMC7451565__F4 Genome-wide association study for mammary structure in Canadian Angus cows EPHB1 SMAD2 CRP RIOK3 HEL-S-92n PADI4 PADI3 PADI1 PMC11117599__F5 SO2 exerts its antifibrotic effects by modulating key intracellular signaling cascades TIMP1 PMC11117599__F4 Anti-fibrosis mechanisms of H2 in fibrotic diseases NLRP3 SMAD2 SMAD4 MTOR PMC11117599__F3 Anti-fibrosis mechanisms of H2S SMAD2 SMAD4 PMC11117599__F2 Anti-fibrosis mechanisms of CO NLRP3 SMAD2 SMAD4 NOX4 PMC11117599__F1 Anti-fibrosis and fibrogenesis mechanisms of NO/NOS system SMAD2 SMAD4 PMC6631643__F9 Schematic representation of macrophage-derived exosomal miR-501-3p in PDAC and the involvement of TGFBR3-mediated TGFB signaling pathway TGFBR3 MSI2 PMC7408826__F2 Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment NOTCH2 dik EGFR MYC LATS1 CDKN2A LATS2 FAT1 KNSTRN PKP1 MDM2 GRB2 NOTCH1 CDK4 PMC3650130__F216 Recently, Anderson and co-workers described cycloisomerization of O-allyl oximes into pyrroles catalyzed by the Ir(I)/Ag(I)-combined system RET ALK PMC8223819__F1 Dynamics of host immune responses to SARS-CoV-2 TLR8 TLR7 HGF IL2RA C1S NOS2 TLR3 CCL3 PMC11025274__F2 Mechanisms by which the gut microbiota promotes CRC metastasis by targeting seeds TLR4 NOD1 EGFR AXIN1 TPH2 CCL2 CDH2 NOD2 CEACAM1 PMC9020229__F3 Endocrine Regulation on Bone by Thyroid IGF1R IGF1 BMP2 PMC8036642__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs: Potential Biomarkers and Therapeutic Targets in Pheochromocytoma/Paraganglioma TSC2 TSC1 PTEN TGFBR3 SOX6 RHEB PMC9020229__F1 Endocrine Regulation on Bone by Thyroid IHH IGF1R IGF1 RUNX2 WNT4 SMAD4 SMAD1 DKFZp781O1323 BMP4 CPZ PMC2581553__F7 The PpsB product and the proposed interaction between the PDIM and FAS-II pathways INHA HEL-S-5 PMC4748276__F5 ApoCanD: Database of human apoptotic proteins in the context of cancer CASP6 TRADD BCL2 TNF FADD BAX PMC5757244__F5 Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops TSC2 TSC1 ARC PMC5757244__F3 Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops HGF CDH8 DISC1 APC GSK3B LRP5 LRP6 EN2 FZD9 LEF1 TSC1 DOCK4 BCL9 PMC10532049__F1 Angiogenesis—An Emerging Role in Organ Fibrosis VEGFC ADAMTS3 CCL21 CCR7 SOX18 ADAMTS14 PMC11810461__F1 MiRNAs that regulate 5-FU resistance in GI cancers ZBTB7A SOCS3 KEAP1 PTN FOXM1 BIRC5 ABCF1 TGFBR2 PTEN RB1 DKK2 E2F3 CMPK1 ING4 HOXA13 PC WEE1 APAF1 GC FZD7 DPYD EIF4E ID1 RAD18 BTG1 TYMS HEL113 DUSP2 SOCS1 PMC7275405__F8 Graph of the interaction pathway CYP3A4 ABCG8 LDLR AQP8 LHCGR UGT2B4 RXRA INSR AQP9 PMC3795998__F1 Signaling pathways of the UPR in response to ER-stress ATF4 EIF2A XBP1 PMC3508164__F12 Proposed model of Cripto-1 modulation of the Wnt/Beta-catenin signaling pathway WNT3A APC GSK3B LRP5 DKK1 PMC4661376__F3 Actin signaling pathways and their association with brain disorders LIMK1 SRA1 ARHA CDH2 OPHN1 CDC42 PMC7680337__F3 Signaling networks involved in Ras-driven oncogenesis TIAM1 RASSF1 PMC3708280__F1 A simplified scheme of signaling pathways and cellular events involved in embryonic skeletal muscle formation WNT3A WNT7A WNT1 SHH BMP4 PMC9338646__F3 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment TBK1 STAT1 NAMPT CGAS CXCL10 IRF3 CCL5 IRF-1 IFNG TET1 PMC2832191__F3A Regulation of autophagy induction in yeast and mammalian cells TSC2 TSC1 EIF2A BCL2 PTEN MTOR IRS1 RHEB PMC6222750__F6 Proposed signaling pathway triggered by kaempferol in EJ cells BAD ATM CCND1 BAX PMC3708280__F3 Molecular background of major signaling pathways responsible for proper development of muscles and muscle stem cells in normal tissues and tissues affected by laminopathy EGF MYF5 APC GSK3B PPA2 CDC2 MTOR LMO7 BMP4 HES1 PMC2882188__F3 Complement cascade HEL-S-62p CD59 C9 C4B_2 SERPING1 MASP2 C4A CR1 PMC2821718__F3 Structure and signalling in the IL-17 receptor superfamily GSK3B TRAF3 TRAF6 IRF3 MYD88 IL17RC PMC3994321__F1 Autophagic pathways in mammalian cells ATG12 ATG3 UVRAG ATG10 MTOR DKFZp686F0183 PMC4924722__F1 The essential role of methylthioadenosine phosphorylase in prostate cancer MTAP TYMS AMD1 TK1 PMC4890907__F3 Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance PCK1 TG PMC5514737__F6 Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins LIMK2 PAK1 LIMK1 RASGRF1 GRB2 SRC ARHA DOCK1 RAC1 CRK PMC2848030__F6 How the presence of virus acts on innate immune system components, i.e OAS1 EGF OAS2 IL6 NCAM1 PMC2964976__F8 CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs HEL-S-2a FYN CD36 PMC9600888__F1 Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling CTSK RUNX2 CYLD BMP2 NFATC1 LRP5 TRAF6 ACP5 SMAD1 DKFZp781O1323 PMC5714869__F6 Schema depicting the Peli1-mediated pathway following SAH TLR4 MYD88 PELI1 PMC10216440__F2 CGRP cellular pathway RUNX2 ATF4 SP7 RAMP1 PMC7482807__F3 Regulatory function of lncRNAs in BC resistance to anti-HER2 targeted therapy TINCR HNRNPA2B1 MYD88 PMC9358258__F14 Neuroprotective Drug Discovery From Phytochemicals and Metabolites for CNS Viral Infection: A Systems Biology Approach With Clinical and Imaging Validation IL10 STAT1 REN IRF3 TNF JUN LAT PMC7482807__F2 LncRNAs-mediated endocrine therapy resistance IGF1R EGFR DUSP7 PMC6850367__F2 PPARy‐mediated effects in the liver TG CD36 PMC3061277__F1 Simple schema of the IGF pathway and approaches to its inhibition BAD IGF1 IGF2 MTOR PMC4865316__F8 Scheme of the mechanisms by which the lack of ZO-2 triggered cell hypertrophy APC GSK3B PTEN MTOR PMC2730990__F2 TGFB can leave you breathless MBP APC PMC7449914__F7 Proposed mechanism: HDAC3 regulates the transcription of cGAS by deacetylating p65 at K122, which plays a role in ischemic/reperfusion-induced neuroinflammation and brain injury TBK1 CGAS HDAC3 IRF3 S100B PMC11749404__F1 Synthesis of Phospholipids in association of ER to mitochondria PC PGP CRLS1 PSD PEMT PMC5378054__F4 Regulation of cellular senescence by transforming growth factor B (TGFB) signaling E2F4 BMP2 BMP7 SP1 BMP4 PMC6416297__F1 Reaction-based specification of the model according to the notation previously introduced HEL-S-61p HEL-S-182mP MTR DHFR TYMS MTHFS PMC11620636__F7 LncRNAs induced by SARS-CoV-2 can exert cis-regulation on the IL-27 pathway EBI3 IRAK1 IRAK2 GBP5 IRAK4 IFNG OASL STAT1 TLR8 GBP1 OAS3 FOSB CSF2 JUN RSAD2 IRF7 CXCL10 IRF3 IL6 TNF IL12B IDO1 NFKB2 JAK1 CSF1 TGFA ZC3H12A GBP4 CCL3 PMC8624248__F2 Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development MMP7 EGF SMAD2 SHH CXCL12 TNF MTOR PMC4898271__F6 The ras signaling pathway EGF EGFR EPHA7 PMC8171374__F1 Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments IL21R TPO CD40 CD80 CR1 ICOS PMC2834863__F1 Transforming growth factor beta (TGFB) and inflammation in cancer MAP3K1 PLG TRAF6 RHO STRAP SKI SMURF1 CDC42 PMC5378054__F1 Transforming growth factor B (TGFB) signaling pathway and its context-dependent regulation C9 SMURF1 PMC6209915__F8 Ras pathway was hyperactivated in Sorafenib-resistant SKOV-3 cells RIN1 ATF2 RASA2 RALA ARHA RAC1 RASA3 CRKL FYN RAP1A BCR LCK ZAP70 GRB2 CCND1 GDNF SYK CDK4 JUN LAT CDC42 PMC7482807__F4 LncRNAs-regulated resistance to targeted therapies beyond HER2 HDAC3 CDK2 CCND1 SPEN CDK4 CDC37 PTEN EZH2 CDK6 PHLPP1 PMC8364356__F1 Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity PLG FDPS HEL-S-92n PMC5770599__F3 Regulation of important signaling pathways by E3 ubiquitin ligases in CRC BRAF CDK2 APC EGFR MDM2 CDC2 MTOR SKP2 PMC5770599__F2 Regulation of Wnt/Beta-catenin signaling and oncogenic NFKB pathway by ubiquitylating enzymes in CRC ZNRF3 RNF43 APC GSK3B LRP5 TRAF6 LRP6 TNF JUN PMC3407218__F5 CXCL12/CXCR4 Axis Triggers the Activation of EGF Receptor and ERK Signaling Pathway in CsA-Induced Proliferation of Human Trophoblast Cells EGF MMP2 CXCR4 EGFR SRC CXCL12 PMC5180413__F10 a In tumor cells expressing ERB (MDA-MB-231, MCF-7), Gamma- and D-T3 bind to and activate the ERB receptor, inducing the expression of pro-apoptotic genes such as MIC-1, EGR-1, and cathepsin-D, finally triggering apoptosis EGR1 XBP1 PMC9656396__F3 Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy TSC2 TSC1 NADK GSK3B SRPK2 ACSS2 PTEN ACLY FBXW7 SGK1 RHEB FASN PMC7299160__F11 Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis GPX4 LPCAT3 TRADD FACL4 SLC7A11 HEL-S-34 RIPK3 TNF MAP3K7IP1 CASP3 RIPK1 GC MDM2 SLC3A2 TRAF2 CASP8 FADD MLKL BAX PMC11087971__F4 The ECM-receptor interaction pathway and (B) the IL-17 signaling pathway CD47 NPNT MMP9 LCN2 CD44 TRAF6 S100A9 DMP1 IL17RC TG S100A7 MMP3 VWF CHAD TRAF2 FADD TRAF4 TAB3 CD36 PMC7957536__F1 Leptin signalling GRB2 MTOR IRS1 STAT3 PMC9146657__F5 Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene ACCS FDPS OGDH SDHA PMC4613493__F1 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism ME1 HEL-S-26 HEL107 PMC5830027__F2 Metabolic pathway of NUCKS1 in physiological and pathological process NUCKS1 IL6 PMC4613493__F2 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism ME1 HEL-S-32 FASN PMC8128161__F2 ER protein quality control capacity in metazoans is monitored by the three branches of the unfolded protein response ATF4 EIF2A XBP1 PMC8234989__F1 New Insights into the Clinical Implications of Yes-Associated Protein in Lung Cancer: Roles in Drug Resistance, Tumor Immunity, Autophagy, and Organoid Development CTCF MYC CCND1 LATS1 RHO HEL113 CDC2 AXL PMC7938660__F1 Metabolic formation of hydroxynorketamines from ketamine CYP2B6 CYP3A4 CYP2A6 PMC5295849__F9 Proposed model of CXCL12 signaling to mTORC1 in BMM TSC2 PLCG1 PI3 TSC1 CXCR4 RAC1 CXCL12 PMC5449256__F1 Oncogenic growth factor signaling mediating tumor escape from cellular immunity STAT1 EGF ALK EGFR CCL5 PTEN CCL2 STAT3 PMC6219204__F2 Crosstalk of FGF10 during pancreatic cancer NFATC1 EGFR FGF10 ADM SOX9 FGF7 PMC3175613__F3 Proposed in vivo innate and adaptive immune responses to AAV vectors TLR9 CCL5 CR1 PMC5240660__F1 Phylogenetic and conserved synteny analysis of PTH related proteins RAB44 DSTYK TMCC2 ETV7 PIR PTH2 PTH DENND2D SFRS3 PTHLH STK38 PI16 MTCH1 PMC3980610__F1 LIF/JAK/STAT3-mediated growth inhibitory signaling in medullary thyroid cancer RET LIF STAT3 PMC3106121__F1 Phosphodiesterases and Cardiac cGMP: Evolving Roles and Controversies RGS4 TRPC6 RGS2 GATA4 PMC3964949__F3 Motif-mediated interactions annotated in the ELM resource mapped onto the KEGG () human Phosphatidylinositol-3′-kinase-(PI3K)–Akt signaling pathway (hsa04151) BAD PTEN EIF4E MTOR RHEB TSC2 TSC1 TLR4 BCR HEL-S-11 MDM2 SYK RBL2 PMC4140952__F1 CPAcP interaction with HER-2 and PI3K/Akt pathway in regulating prostate cell homeostasis BAD PMC5809759__F1 Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization? ATF4 XBP1 PMC4016833__F1 Signaling events in murine heart development and cardiac ESC differentiation NODAL TBX5 SHF ISL1 PMC3347317__F2 Modulation of type I IFN production by PRRSV RNASEL TBK1 ISG15 RNASE1 GP5 IRF7 TRAF3 IRF3 TYK2 JAK1 TLR3 PMC7102917__F2 Major downstream signaling pathways in GISTs KIT PDGFRA MTOR STAT3 PMC5682898__F7 Proposed model for the neuroprotective effects of XJDH in OGD/R injury TLR4 TRAF6 MYD88 PMC5240660__F9 Evolutionary history of the PTH family in vertebrates FGF23 CS PTH2 PHOSPHO1 ENTPD5 PTHLH PMC3314445__F9 An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated AB oligomers ABO IRS1 GLP1R PMC9525705__F1 mtDNA acts as a DAMP to activate neuroinflammation NLRP3 TLR9 IRF3 TNF IL1B PMC9280480__F2 SUMOylation Targets Associated With Wnt/Beta-Catenin Pathway APC LRP5 CD44 SMAD4 LRP6 RANBP2 TCF4 PMC6073455__F4 SCF and its active ingredients protect against inflammation in NDs TLR4 TRADD TRAF6 MYD88 TNF TRAF2 FADD PMC2955993__F3 Complement and Periodontitis TLR1 PMC2955993__F1 Complement and Periodontitis HEL-S-62p CD59 CD46 FH C1S CR1 PMC5543471__F8 Molecular mechanism of the mTOR pathway in Vil‐Cre;Pkd2 f3/f3 mice, with or without rapamycin treatment CDK2 CDC2 ELL PMC9553089__F2 Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study RARA PGGT1B HMGB1 MVD FDPS COX10 RHO FNTA IPP GGPS1 RABGGTB CD81 PMC4478622__F1 Scheme of the engineered metabolic pathway for the production of 1,2-propanediol and 1-propanol in C GID4 VIT PMC5989173__F1 Molecular mechanism of SOCS- and IRF-regulated cytokine signaling in macrophages during ALI/ARDS SOCS3 JAK1 PMC8380478__F2 Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application MSC CCL21 CD80 PMC9497173__F1 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment ME1 GOT2 GPT2 RPIA CIT RPE GLUD1 HEL-S-32 GFPT1 HK2 MAL GLS PMC7290664__F6 Functions of caspase-2 in DNA damage and cellular stress OMP ATM BCL2 CDC2 ATR BAX PMC2640319__F1 Insulin and amino acid signaling pathway leading to the stimulation of translation initiation TSC2 TSC1 PTEN EIF4E RPS6 MTOR IRS1 PMC7290664__F9 Extrinsic and intrinsic pathways of apoptosis TRADD BCL2 FADD BAX PMC9497173__F3 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment ULK1 ATG16L1 ATG12 ATG3 ATG101 ULK2 ATG14 DKFZp686F0183 PMC8198409__F2 Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1 FYN DGKA PMC10942825__F6 Signaling pathways of DUSP22 in EndMT SMAD2 PMC5869001__F6 Hypothesized KS biosynthetic pathway in the absence of functional B3GnT7 CHST6 B4GALT4 CHST5 PMC4376865__F4 H-Ferritin-Regulated MicroRNAs Modulate Gene Expression in K562 Cells CRCP RNF20 ASXL2 VEGFB PMC1560089__F7 Proposed LITAF signaling pathway TLR4 LITAF MYD88 PMC9329130__F1 Over-expression of a cyanobacterial gene for 1-deoxy-d-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll: carotenoid ratios HEL-S-62p CS IPP PMC11395697__F8 Tumor–immune interactions and the dynamic interplay between tumor killing and immunosuppressive mechanisms EGF CCL11 HGF NGF CS CCL26 FGF2 MMP9 APC VEGFA CCL7 CCL5 CCL2 HEL-S-130P CCL24 PRF1 ARG1 OSM CCL3 PMC5541935__F2 Comparison of Biomarker Expression between Proximal and Distal Colorectal Adenomas: The Tennessee-Indiana Adenoma Recurrence Study EGF APC EGFR TGFBR1 FOXQ1 CCND1 SRC LRP6 MTOR TF PMC11395697__F7 Gut microbiome–host interactions in colorectal cancer development TLR4 MYD88 PMC4928883__F3 Fundamentals of cancer metabolism MTHFD2L SHMT1 ACSS2 MTHFD1 MTHFD2 PHGDH HEL-S-162eP HEL-S-26 PC FH HEL-S-51e ACLY HK2 GLS PMC11395697__F4 The colitis-associated cancer pathway in inflammatory bowel disease APC STAT3 PMC11395697__F3 Serrated neoplasia routes BRAF PMC4629535__F5 Canonical pathway and gene network analysis of the 18 identifiers that were expressed in the lungs of PQ-free rats TMEM43 GPR161 RASA2 GPR160 PCNT EIF4EBP1 ZNF675 MKRN1 GPR87 TP53BP1 DPH1 TAOK2 FFAR3 TRIM35 TPRKB MAP3K1 PEBP4 SPRED1 GPR137 SHOC2 SHISA5 MAP3K13 ZNHIT6 GPR39 P2RY14 SESN2 PMC4629535__F4 Proposed p53 signaling pathway in PQ-treated rat lungs TIGAR AIP HIPK2 PERP ATM GML MDM2 PTEN ATR BRCA1 BAX PMC7701955__F2 Canonical and non‐canonical TGF‐B signaling YAP1 SMAD2 SMAD4 TRAF6 NOX4 ARHA MTOR SMURF1 SOX9 FOXP3 BIK TRAF4 CDC42 PMC3724248__F1 MicroRNA pathway is universal to all mammalian miRNAs AGO2 DGCR8 DROSHA RAN PMC3944819__F7 Schematic of ANDV N and GnGc protein regulation of TBK1 signaling TBK1 TRAF3 IRF3 MAVS PMC4629535__F6 Canonical pathway and gene network analysis of the 26 identifiers that were expressed in the lungs of PQ-treated rats HIPK2 GPR89B TAAR8 AIFM1 ROBO4 PAH PANK1 UBC PACS2 MARCO STK17A CPOX VTCN1 UNK CD55 SP1 IRF2BP2 CTSW TP53RK ELK3 MAP3K1 GPR61 VN1R3 NLRX1 RNF125 BCOR GPR174 DUSP10 HNF4A VN1R2 CDKN2AIP AAK1 BRSK1 SESN1 DHODH HEL-S-93 DYRK2 SHC1 PMC6225148__F2 Current understanding of the mechanism of action of T-oligos ATM BAX PMC2275788__F2 Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast ARL1 RAD50 TAF9 RAD52 RAD51 ARL3 RAD18 VPS51 SAP30 VPS29 CDC73 PMC10819295__F2 Possible signaling pathways activated by ORF8 IL17RA TRAF6 IRF3 IL6 MYD88 PMC11847756__F3 Topological analysis of the PPI network using Cytoscape identified 10 key hub genes, shown in this network visualization CASP3 ALB BCL2 IL6 TNF HIF1A JUN STAT3 PMC8469696__F2 Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer ASPSCR1 UBXN7 PPP1R7 PPP1R11 UBXN2B ACTR6 SVIP SNTG2 UBXN11 UBXN10 ALKBH5 TMEM129 VCPKMT ZNF778 YOD1 VCPIP1 XAF1 PLAA SYF2 UBXN6 SELS VCP UFD1L PHAX PMC7537271__F3 SARS‐CoV‐2 activates innate immune pathways TBK1 NLRP3 TLR8 HMGB1 TLR7 TLR4 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC3077544__F2 Akt regulates numerous biological functions by phosphorylating distinct protein substrates TSC2 PAK1 BAD GSK3B MDM2 ACAP1 MTOR SKP2 PMC3994404__F2 KIT signaling pathways STAT1 PLCG1 KIT BTK GRB2 GRB7 SOCS1 STAT3 PMC11847756__F2 PPI network was constructed using STRING to visualize the interactions among the 140 shared targets between Chrysin and breast cancer AFP CDKN2C GSK3B ADAM17 FOXP3 MMP7 FGFR1 AHR SHBG MMP2 STS NOS2 ABCC2 ABCB1 JUN PRSS1 CYP1B1 CXCL10 HSD17B1 ARHA CTNNA1 CYP2A6 NR1C1 AURKA SULT1A1 NFKBIA TFF1 RELA DUSP16 ABCC1 TP73 PCNA STAT3 PMC4466411__F5 Schematic model of the molecular mechanisms associated with PD-induced autophagy in NCI-H460 and A549 cells ATG3 MTOR PMC8235734__F4 Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression CD47 CCR2 TLR7 CXCR4 CCL2 CXCL12 CSF1 PMC4511109__F3 Live to die another way: modes of programmed cell death and the signals emanating from dying cells CASP3 RIPK1 TRADD CYLD TRAF3 RIPK3 TRAF2 CASP8 FADD MLKL PMC11505501__F1 Mechanisms underlying signaling pathway crosstalk in OA ITGB3 CTSK RUNX2 SMAD2 CXCR4 OSCAR TRAF6 ACP5 CALCR TNF SMAD1 DKFZp781O1323 PMC7682347__F7 NFKB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons LIF STAT3 PMC8430581__F2 Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease ROCK2 SOCS3 HEL-S-171mP APC IL15RA MTOR IL23R STAT3 PMC12046027__F8 Interferon-Induced OAS-RNase L/PKR Pathway and the effect of hnRNP A1 depletion RNASEL OAS1 OAS2 RSAD2 IRF7 TLR3 IFIT1 PMC4780366__F4 Molecular hypothesis of tumor progression in uveal melanoma, highlighting the role of PRAME reported herein EIF1AX BAP1 PMC3574814__F1 MYC target genes in the polyamine pathway EIF5A2 SRM MYC AMD1 PMC7311357__F1 Illustration of the main components of the ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes along with the other molecular components reported to be involved in SARS-CoV-2 infection (e.g CTSL APC FURIN ACE2 TMPRSS2 PMC10623085__F7 Proposed signaling pathway by which NE mediates HepG2 cell proliferation TSC2 TSC1 RHEB PMC5452197__F3 Schematic representation of the intestinal inflammatory pathway expression altered by Hydryeast supplementation (DHY8) in dextran sodium sulfate (DSS)-induced colitis H1-2 STAT4 NOD2 IFNG PMC5642390__F6 The diagram of a potential signaling pathway that RACK1 regulates the cell proliferation and cell invasion in cervical cancer cells STAT1 CCND1 PMC4445275__F1 Genes involved in the leukocyte transendothelial migration and Toll-like receptor signaling pathways CD14 VASP CTSK LBP TEC FADD PMC3551337__F3 CRM1 regulates the PI3K signaling pathway in MCL BTK BCR CDK2 SYK PTEN PMC7064362__F5 Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NFKB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2+-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression BTK NFATC1 BASH FOS TEC TRAF6 SYK PMC8909792__F3 Ehrlichia chaffeensis intracellular life cycle and host innate response TLR7 TLR9 MYD88 NOD2 PMC10520786__F2 Nrf2-mediated therapeutic effects of dietary flavones in different diseases FYN KEAP1 ENG SIRT1 PMC8909792__F2 Rickettsia spp. intracellular life cycle and host innate responses NLRP3 TLR4 MYD88 TG PMC7136166__F1 Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease IGF1 PTH PMC12031180__F7 CTN induces apoptosis and cell cycle arrest via the TGFB signaling pathway, and 4-HDK mitigates these effects CASP3 PARP14 CDKN1A PMC10520786__F3 Nrf2 modulates inflammation and apoptosis COX2 KEAP1 BAX PMC8038462__F2 DNA repair pathway in the prostate epithelium involving hereditary prostate cancer (HPCa) related genes: mismatch repair or MMR (A); homologous recombination or HR (B) CHEK2 PALB2 BRCA2 MSH6 RAD50 LIG1 MSH2 BRCA1 PMS2 PMC10992410__F2 Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast ERG MIIP ENG GALP PMC10755469__F2 Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury NLRP3 CGAS MPO GSDMD PMC7871890__F1 Type I and III interferons response following SARS-CoV-2 sensing during controlled (left and central cell) and uncontrolled (right cell) infection TBK1 STAT2 IRF3 IFNAR2 MYD88 IFNAR1 IFNLR1 STAT1 TLR7 TYK2 JAK1 ACE2 IRF-1 IL1B MAVS PMC7871890__F2 IFN signaling through the Jak-STAT pathway STAT1 STAT2 IFNK IRF9 TYK2 JAK1 PMC9146752__F1 Research Progress on Transorgan Regulation of the Cardiovascular and Motor System through Cardiogenic Exosomes TSG101 ERBB4 IRAK1 CDIP1 PMC8902450__F8 Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway CCND1 CCNE1 BAX PMC3184062__F9 Scheme for poly(I:C)-induced apoptotic signaling pathway in high TLR3-expressing NB cells (left panel), but not low TLR3-expressing NB cells (right panel) HP IRF3 TLR3 PMC7251113__F1 Proposed mechanism of synergy of co-encapsulated vitamin E succinate modified octahistidine-octaarginine (VES-H8R8) and palmityl-doxorubicin (pDOX) HRG PGP ROS1 PMC2836529__F3 Neurotrophin actions on the endothelial cell NGF MMP2 VEGFA BDNF PMC3157706__F1 Molecular pathways in LSCs of CML ALOX5 PTEN MTOR PMC11948946__F8 Analysis of gene expression related to hormone signaling pathways BIN2 ERF EBF2 PMC6997396__F5 Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system TSC2 TSC1 MTOR TG PMC8574122__F1 PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19 TSC2 TSC1 PTEN DEPTOR SGK1 RHEB MLST8 PMC11850271__F2 Regulatory role of posttranslational modifications in the activation of RIPK1 TBK1 RIPK1 TRADD CYLD RIPK3 PELI1 OPTN FADD TAB3 PMC11850271__F1 TNF-Alpha-driven formation of necroptosis-specific protein complexes RIPK1 TANK TRADD RIPK3 TRAF2 FADD MLKL PMC3275810__F2 Schematic display of the molecular interactions of apoptosis related molecules in dental apoptosis indicating the central position of the mitochondria pathway, which has been shown to be essential EDAR TNLG7C FADD BAX PMC11118972__F5 Effect of pteF deletion on cell metabolism LPA CIT MAL PMC1215521__F7 Possible gene regulation in macrophage THP-1 stimulated by theophylline VEGFC TCN2 IL6ST CD36 PMC4338781__F4 DMXAA modulates mTOR signaling pathway in A549 cells.Notes: A549 cells were treated with DMXAA 10 μM for 24 hours and the protein samples were subject to quantitative proteomic analysis TSC2 RICTOR ULK1 TSC1 PC ELF3 EIF4E RPS6 EIF4B IRS1 INSR PMC3606085__F4 NER pathway RAD1 PCNA PMC4338781__F3 Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach ELF2 HEL-S-28 RHO MTOR ELF4 PMC4137134__F1 Conceivable transforming growth factor (TGF)B1-initiated cellular events leading to myofibroblast activation and extracellular matrix (ECM) synthesis culminating into renal fibrosis SMAD6 SMAD4 NOX4 RHO PMC6914774__F1 The emerging treatment landscape of targeted therapy in non-small-cell lung cancer EGF BRAF PTEN MTOR PMC7755476__F9 Protein-protein interaction network of E2F coexpression genes (GeneMANIA) MYB CENPM TCEA3 BLM RPA1 SMAD2 TMEM208 NOL3 CEP55 SRSF10 ID3 E2F3 UBE2S ECT2 ELMO3 CDCA3 TGFA PMC6050903__F1 Regulated cell death signaling pathways RIPK1 GPX4 RIPK3 PARP1 IL1B PMC3086918__F1 Mind the dbGAP: The Application of Data Mining to Identify Biological Mechanisms c-fgr GCLC CFH AXIN1 ENG TGFB1 TNMD SCYL3 PMC8495593__F2 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers TSC2 TSC1 PTEN RHEB PMC8495593__F1 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers SHH LRP6 SMO PMC8495593__F3 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers XPC XPA PCNA PMC4547588__F1 Interferons and other inflammatory cytokines control HBV infection of hepatocytes via multiple, distinct mechanisms STAT1 STAT2 IRF9 TYK2 JAK1 IL1B PMC8236123__F9 Activated neutrophils polarize protumorigenic interleukin‐17A‐producing T helper subsets through TNF‐A‐B7‐H2‐dependent pathway in human gastric cancer CXCR1 CXCL8 CXCL6 PMC3115056__F1 Regulation of neural process growth, elaboration and structural plasticity by NFKB CNTF NGF TRADD LCK SRC SYK BDNF PMC8578378__F1 IL-17 signaling pathway in mucosal candidiasis S100A8 IL17A TYK2 JAK1 IL17RC PMC12008290__F10 Astragalus mongholicus and Hedyotis diffusa willd inhibit cell proliferation by attenuating the miR-582-3p-p27 signaling pathway in LUAD CDK2 CCND1 CDK4 PMC5984065__F5 TGFB induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation Diagrammatic representation of the TGFB signaling pathway in SM10 growth inhibition and trophoblast differentiation SMAD2 SMAD4 PMC3356111__F9 Schematic representation of TNF’s dual effect on rat pinealocytes NFKBIA RELA TNF AANAT PMC2954716__F4 Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues PDE3B RICTOR GSK3B GSK3A EIF4E MTOR IRS1 PMC8096095__F5 SRI-21979 alters the expression of transcripts involved in cAMP signaling and apoptosis BAD MAPK3 BCL2L1 RHO CASP2 SOX9 AMH ATM BAX CTSL MAP2K2 ARHA RAC1 TNF CASP10 LMNA ADCY3 CREB3 CALM1 CASP3 PAK1 RP1 BCL2 GNAS TRAF2 FADD HRK VAV2 PMC2743116__F1 Ras/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) NF1 BRAF GRB2 SPRED1 SOS1 PMC9604790__F3 Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine CD63 NF2 EGFR CD44 ARHA SCRIB LATS1 RAC1 LATS2 FAT1 CDK7 BRD4 PMC10748259__F8 Antiviral effectors and cell metabolism interactions RNASEL ISG15 CH25H OAS1 STAT2 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 IFI6 IFNLR1 PMC10748259__F7 Involvement of metabolism in viral genome detection TBK1 TLR8 CGAS TLR7 TLR9 TRAF5 IRF7 TRAF3 IRF3 TRAF2 TLR3 MAVS PMC10748259__F6 Molecular mechanisms leading to the detection of viral genome TBK1 CGAS TLR9 IRF7 TRAF3 IRF3 TLR3 NLRP3 TLR8 TLR7 TRAF5 TRAF2 MAVS TRAF4 PMC8471503__F8 Identifying GPSM Family Members as Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis CORT CDC20 ATM APC ATR COMP SKP2 PMC4142049__F3 LOX-1 signaling mechanistically links atherosclerosis, hypertension, and diabetes MTOR SIRT1 PMC3569116__F1 Glucose metabolic pathway HEL-S-49 ENO2 DLD PGAM1 HEL-S-68p HEL-S-162eP PMC7698460__F3 Recent strategies aimed at targeting TAMs in combination with ICIs for melanoma treatment PIGF CD163 VEGFA ARG1 PMC12184675__F3 CGAS-STING signaling pathway in immune responses to SARS-CoV-2 and DNA CGAS IRF7 IRF3 TNF PMC12184675__F2 Molecular mechanisms of SARS-CoV-2-induced pulmonary injury via apoptotic pathways TRADD TRAF2 FADD BAX PMC2279300__F6 Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors SOS1 TARP VAV2 PMC10380759__F2 Clinical Significance of CD73 in Cancer CD80 PMC5992506__F2 Cholesterol synthesis and cancer cell proliferation EGFR ELL PMC12184675__F4 Depiction of the innate immune signalling pathway, focusing on RIG-I/MDA-5/MAVS and their inhibition by SARS-CoV-2 proteins TBK1 STAT2 IRF7 IRAK1 IRF9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TNF MAP3K7IP1 TLR3 TOMM70 STAT1 TYK2 JAK1 MAVS PMC6052888__F8 Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism KEAP1 MYC MTOR ROS1 PMC6657305__F1 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ HAAO NAMPT KMO PNP PMC8321875__F4 Neuroprotective Potential of Ellagic Acid: A Critical Review KEAP1 PTEN IRS1 PMC7590081__F1 Catabolic pathways regulating TG levels in cells PNPLA3 TG PMC6052888__F9 Antioxidants neutralize mitochondrial ROS (mtROS) MCAT UCP2 SIRT3 PMC5632899__F1 Schematic diagram of an IL-33 signaling pathway IL33 TRAF6 MYD88 PMC6657305__F3 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ NUDT13 NADK SARM1 HEL-S-162eP PMC6052888__F5 Tryptophan metabolism mediated immune cell response AHR APC MTOR SIRT3 PMC4072077__F1 MicroRNAs (miRNAs) are involved in pathogenesis of multiple myeloma (MM) by targeting some signaling pathways in myeloma cells ASF1B IGF1R IGF1 PSMD10 IRAK1 MDM2 SOCS1 STAT3 PMC7258858__F1 Actions of thyroid hormones (THs) and their corresponding receptors MYB PIM1 SI CDK2 F2 CCND1 ENG CTSH FURIN FOXO1 DKK4 PMC4069681__F1 Rho protein GTPases and their interactions with NFKB: crossroads of inflammation and matrix biology MAP3K1 ARHH TRADD ROCK1 ARHA RAC1 IFNG RAC3 BCR CD40 TRAF2 RHOB IL1B CDC42 PMC8465440__F2 Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway CTSS MAPK8 PIM2 FLT4 GSK3B MAPK14 MAOA ALOX5 POR NQO2 KDR HEL-S-11 SRC CA4 CTSL KCNN3 MAPKAPK2 MAP3K1 CTSK CES1 PTPN13 HEL-S-31 AURKB MAP3K14 CA12 BACE1 IGF1R MPO BRAF NR3A2 EGFR TYMP MAP2K3 INSR BTK PTPN1 XDH SELE PDE3B NUAK1 PPIG RPS6KA5 CA9 AURKA IKBKB PTPRC RPS6KB1 METAP1 PIM3 HEL164 LYN SYK TYK2 MCL1 PMC4263464__F1 Top overlapped pathways for non-users (top) and users (bottom) of oral contraceptives.Notes: Hexagon shaped are genes SOCS3 GRIP1 CSNK2A1 MYC BCL2L1 MAP2K6 CRKL CDK6 PRKCA MAPK1 ARPC1B ACTR2 PTPRT ARHGEF1 ERBB3 BAIAP2 CDK5 CDK8 IRS1 ARPC4 CDK2 SMURF2 GRB2 BCL2 PRKCH MYLK MAP2K4 NR3A2 SFN ROCK1 EGFR sm-M20 HEL-S-15 CEBPB CDK4 PTPN6 JUN MKRN2 ARHA IL6 TRIM25 MAGEA4 ID1 HEL-S-69p IKBKB CREBBP YIPF2 PELP1 ERBB2 NFKB1 CCNB2 SYK IL6ST RAF1 CDK3 SOCS1 PMC7865483__F7 Key players of the CoA biosynthetic pathway in bacteria, yeast and mammals PPCS FGF2 PPCDC COASY PMC3630363__F8 Temporal restriction of the Cdk1/Cdc5/Mus81 pathway outside S phase is important for genome integrity CDC2 RAD18 PMC11721695__S1 hCeO2@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway NLRP3 RUNX2 PMC9598519__F10 Glutathione and Glutaredoxin in Redox Regulation and Cell Signaling of the Lens EGFR GRB2 SRC PMC3925422__F3 Breaking bad: Manipulation of the host response by Porphyromonas gingivalis HEL-S-62p CD14 TLR4 GSK3B RAC1 TLR1 IRF-1 IFNG PMC5985449__F2 Sialic acid metabolic pathway GNE CMAS NANS NANP PMC7487050__F2 Metastatic process in breast cancer SALL4 FOSL1 TWIST1 ZEB2 VEGFA IL6 CXCL12 CDH2 HOXA2 HIF1AN PMC7487050__F1 Brief summary of miRNA biogenesis and aspects of regulation in breast cancer and metastasis AGO2 DGCR8 DICER1 METTL3 EGFR DROSHA SPRY2 PMC4750533__F1 The Akt pathway and downstream effectors BAD HEL-S-28 PTEN DEPTOR IRS1 TSC2 BCR GAB2 SI MDM2 PFKFB2 SYK JAK1 GAL MYT1 CD19 BAX PMC7487050__F3 TGFB stimulation of EMT, angiogenesis, and stemness in breast cancer progression toward metastasis NOTCH2 TH SALL4 NOTCH4 SMAD2 TGFBR1 JAG2 VEGFA SMAD4 ARHA PTEN DLL3 NOTCH3 ADAM17 HMGA2 HOXD10 TWIST1 DLL4 ZEB2 NOTCH1 ADAM10 PMC8224563__F1 Autophagy Induction as a Host-Directed Therapeutic Strategy against Mycobacterium tuberculosis Infection TSC2 ULK1 TSC1 P2RX7 ATG101 ULK2 UVRAG OPTN ATG14 SIRT1 SIRT3 PMC5985295__F2 IFN-dependent and -independent ISG transcription mediated by complexes comprised unphosphorylated STATs RP9 IFNGR2 TYK2 IFNAR2 IFNAR1 IFNGR1 STAR PMC7744330__F8 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization ENPP1 FGF23 SFRP1 ANKH WIF1 FZD8 PMC5985295__F5 Cooperation of unphosphorylated and phosphorylated ISGF3 and GAF components and IRF1 in the regulation of basal and IFN-induced transcription AK2 IRF9 IFNGR2 IFNAR1 IFNGR1 IRF-1 PMC7047626__F2 Mitophagy and DNA Damage Signaling in Human Aging PINK1 USP15 VPS13D LAMP2 ARIH1 FUNDC1 AMBRA1 BNIP3 PGAM5 USP30 SMURF1 PMC8853826__F1 Insulin synthesis and secretion in the islet Beta-cell and its control by mirNas RYR1 NEUROD1 PMC7047626__F4 Mitophagy and DNA Damage Signaling in Human Aging TBK1 TSC2 PINK1 CGAS ATM PARP1 MTOR WRN SIRT1 PMC4808853__F2 Long chain polyunsaturated fatty acid biosynthetic pathway FADS2 ELOVL5 FADS1 ELOVL2 PMC10520679__F1 Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets RAB35 PLD2 RAB27A EGFR RAB31 SRC RAB27B ARF6 RAB13 PMC8853826__F2 Insulin signal transduction and metabolic responses in peripheral tissues and their control by mirNas SOCS2 TCF2 FOXO1 SOCS1 PMC7744330__F3 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization ENPP1 PTN RUNX2 COL3A1 POSTN CLEC4E FLRT2 MYH10 FGF23 COL16A1 MMP2 COL12A1 BMP8A opn XB FNDC1 BMP3 CILP2 WNT16 LRP5 PTH DMP1 WNT10B ADAMTS14 NFATC2 MMP14 THBS2 THBS3 PTCH1 MYLK COL25A1 PMC10520679__F3 An illustration demonstrates the involvement of ncRNAs and oncogenic signaling pathways in CRC metastasis YAP1 ANXA2 ARHA FUT4 PTEN MTOR PMC11575262__F9 Seed and foliar application of nano-selenium improves sesame triacylglycerols and oil yield via photosynthetic pigment and enzymatic and chemical antioxidant enhancement revealed by spectrophotometric, UHPLC-analysis and chemometric modeling PC GPT ABCA9 HEL-S-5 PMC8230057__F1 How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System NUP153 EGR1 CPSF6 RAE1 NUP214 NUP98 IRF3 NUP62 IPO5 RAN NXT1 CP PMC9204157__F6 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis TBK1 TSC2 TSC1 IGF1R MAP3K7 RHO GAL MTOR PMC5748001__F3 Flexible Roles for Proteoglycan Sulfation and Receptor Signaling EGFR GSK3B SRC RHO MTOR LINGO1 PMC10418475__F1 Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects DCT MC1R PMC2831232__F2 NKT cells in immune-mediated pregnancy loss TLR4 TLR9 CD1D APC CD40 PMC3595309__F5 Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFKB signaling pathway VEGFC CSA2 CDH17 PMC3118659__F13 NAD+ biosynthesis and salvage pathways NAPRT NAMPT HEL-S-90n PMC4688896__F1 Dysregulation and restoration of translational homeostasis in fragile X syndrome TSC2 TSC1 PDK2 EIF4E MTOR EIF4B RHEB PMC2963142__F1 TLR signaling pathway and downstream effector molecules TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TIRAP PMC6523349__F3 YAP regulation in early stages of prostate cancer ERG NF2 LATS1 FRMD6 PMC8506026__F7 Crosstalk Between Abnormal TSHR Signaling Activation and PTEN/PI3K in the Dedifferentiation of Thyroid Cancer Cells TSHR ARHA PTEN MTOR PMC3417478__F1 Cyclic AMP elevation leads to induction of the SOCS-3 gene in VECs SOCS3 SP3 STAT3 PMC11635874__F2 BMP signaling pathway in bone regeneration GREM1 RUNX2 SMAD6 SMAD4 DLX5 MAP3K7IP1 SMURF1 SMAD1 DKFZp781O1323 PMC11635874__F1 TGFB signaling in bone SMAD2 SMURF2 SMAD4 MAP3K7IP1 PMC2827416__F5 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 60 kg LPL TG PMC3707951__F3 Proposed intracellular effects of S100A1, S100A4, and S100A8/S100A9 GC S100A8 RYR1 CCN3 S100A9 S100A1 S100A4 RYR2 PMC10472646__F3 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application IDO1 USP14 CXCL12 SIRT1 PMC4267164__F2 NOD1 and NOD2 signaling NOD1 RELB DAP CSA2 NOD2 TAB3 PMC4267164__F1 TLRs signaling TBK1 TLR5 TLR4 IRF7 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 MAP3K7IP1 TIRAP PMC10472646__F1 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application CTLA4 CCDC6 ABCB1 FOXP3 PMC3707951__F4 S100A8 induction in macrophages TLR4 EBP S100A8 TRAF3 TRAF6 IRF3 MYD88 TLR3 STAT3 PMC4506691__F2 Pathways of steroid hormone synthesis in 21-hydroxylase deficiency, including backdoor pathway and 11-oxygenated androgens HSD3B2 HSD17B3 AKR1C2 CYP17A1 HSD17B6 PMC6523349__F5 YAP/TAZ regulate prostate cancer stem cells (PCSCs) SOX2 PDE5A LATS1 LATS2 PMC6523349__F4 Hippo pathway regulation of advanced prostate cancer ETV4 SMAD4 ARHA PTEN EZH2 ETV5 LATS2 PMC11541314__F6 Codeine and morphine Metabolism pathway as the most significant curated signaling pathway with a p-value of 3 UGT1A3 ABCC3 SLCO1B1 UGT1A9 CYP3A4 UGT2B7 ABCC2 UGT2B4 ABCB1 UGT1A1 PMC2827416__F6 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 100 kg LPL TG PMC6301029__F4 Egg activation in Drosophila APC GSK3B CDC2 PMC3792024__F4 Meta-Analysis Identifies NFKB as a Therapeutic Target in Renal Cancer CMPK2 MYC RNF213 CCL2 HMOX1 STAT1 BTC TLE4 NMI IRF-1 IRF2 CXCL11 NAMPT IRF7 VCAN CXCL10 LTB ATF3 ENG HLA-B HLA-C HLA-F IL15 TNC VEGFC CSTA TPP2 BCL2A1 PCDH17 VCAM1 CHKA BCL2 HEL113 BDNF MEF2C CASP4 PARP14 PRKCE CD48 IL11 NOD2 CXCL13 ISG15 SP110 OAS1 IL18 XAF1 TAP2 BASH LIPG SFRP1 PTTG1 RPRM BMP2 CD44 CXCL2 TNFRSF11B TLR3 TCIRG1 TAPBP IKBKB IL7 TNFSF10 GBP4 PSMB10 SOCS1 PMC4726088__F9 Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1 ERBB4 NRG1 BDNF PSD PMC7982428__F1 Hedgehog (HH) signaling pathway and its related regulators, target genes and current therapeutic landscape EGF BOC GPC5 KIF7 BRAF FOXM1 GPC3 CD44 RAB23 BMI1 GAS1 WIF1 LEF1 SUFU GLI3 CCND1 BCL2 SMO ABCG2 ADRBK1 ITCH PMC4562315__F1 Emerging roles of YAP and TAZ in cancer BIRC5 AMOTL2 NF2 AREG LATS1 MOB1A MOBKL1A LATS2 PMC9442031__F2 Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives CYP27A1 GCA CYP8B1 CYP7B1 BAAT CYP7A1 PMC3335841__F3 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation RRAGD POLD2 TIAL1 HAMP M6PR BMP2 MYLIP BACE2 CPNE1 CD244 ITM2C POLD3 SMAD9 DKFZp686L0365 GGA2 SORL1 HGS APP IL2 ATP6V1A DIPLA1 OGG1 PMC3335841__F2 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation HAVCR1 ARHH CDC6 PMC7428719__F1 Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders MTOR NQO1 PMC8968680__F2 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology BAD APC MDM2 CASP9 CCND1 MTOR PMC6591730__F3 Causes and Consequences of Enzyme-Induced Cytosine Deamination MSH6 MSH2 POLN ATR UNG PMC5716453__F6 Molecular mechanisms underlying the neuroprotective effect of IGFBP-6 via IGF-1R-dependent signaling IGF1R IGF1 IGF2 IGFBP6 BAX PMC8968680__F3 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology ERBB2 GRB2 CCND1 CDK4 FLT3 PMC6232560__F3 Oncogenic signaling network activated by bile acids MMP11 EGFR STAT3 PMC4141507__F1 fHLH: becoming a blended family RAB27A LYST STX11 PRF1 AP3B1 PMC2483757__F1 Kinetic model of the EpoR/GATA-1 network implicated in erythrocyte progenitor commitment EPOR EPO PMC5669448__F3 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles MVK PMC5669448__F4 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles MVK PSTPIP1 PMC9450364__F4 Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells PON2 SET UQCRB CDC23 CDK5 UGDH NDUFS3 TK1 NDUFA2 ENOPH1 CYLD NDUFA13 NDUFB3 NDUFA9 DUT NDUFS5 NDUFB5 URM1 PMC6331455__F5 Role of Nrf2 in HCC KEAP1 GSK3B FGF19 FGFR4 PMC3418709__F1 Hepatitis C, Porphyria Cutanea Tarda, and Liver Iron: An Update FECH UROD HFE CYP1A2 PMC3551337__F2 Major pathogenic lesions in MCL TSC2 BCR ATM CDK2 TRAF3 MDM2 RELB CCND1 SYK PTEN TRAF2 PMC8618802__F7 Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy ATM APAF1 DRAM1 MCL1 MTOR ATR FADD BAX PMC3874812__F8 Cav-1 phosphorylation-dependent LPS signaling pathway in mediating lung inflammation in endothelial cells CD14 TLR4 IRAK1 SRC TRAF6 IRAK4 MYD88 PMC3578301__F4 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets JAG2 RORA GATA3 IFNG FOXP3 PMC3578301__F3 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets LCK GATA3 PMC5600322__F2 HSC Niche Biology and HSC Expansion Ex Vivo MEIS1 TPO HIF1A HEL-S-133P PMC4705475__F6 RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism NAMPT AREG ZP4 PPP4C SPN RYR2 TAOK2 PTDSS1 ZIC1 TBX6 NRXN1 KCTD13 MVP PMC2805916__F1 Galectins, integrins and cell migration ADAM15 ARHA SP1 PMC7059861__F1 Main pathways of TRP degradation, including relevant enzymes [modified after (, )] IDO1 KYNU AHR KMO IDO2 PMC4562315__F3 Emerging roles of YAP and TAZ in cancer ATM APC AXIN1 TP73 LATS1 GPR49 AXIN2 LATS2 BAX PMC11174998__F1 One-carbon metabolism HEL-S-61p BAD DHFR MTRR PMC4562315__F2 Emerging roles of YAP and TAZ in cancer DICER1 AMOT APC VGLL4 SCRIB LATS1 RHO PTEN LATS2 TRIO PMC7133116__F2 Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 FBP2 FBP1 PGP RPIA TNLG7C RPE HPR SDHA PMC7897244__F1 TGFB signaling pathway BMPR2 ACVR2B ACVR2A TGFBR2 AMHR2 PMC9204157__F2 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis PLG ARHA TBR1 MTOR PMC7897244__F6 Proposed pathological roles of ligand competition SMAD2 PAH SMAD1 DKFZp781O1323 PMC9204157__F4 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis MAP3K19 SMAD2 CXCR4 EGFR SMAD4 SRC CXCL12 PMC10671169__F7 NXC736 Attenuates Radiation-Induced Lung Fibrosis via Regulating NLRP3/IL-1B Signaling Pathway NLRP3 SMAD2 SMAD4 S1PR1 S1PR4 PMC11949690__F6 Findings—hypothalamic IGF1 signaling can be dynamically regulated POMC IGF1R IGF1 NPY AgRP SPX CARTPT GAL IGFBP5 IRS1 FOXO1 INSR PMC5779870__F1 The PDGF signaling pathway STAT1 ARHA PTEN JAK1 CEBPB PMC3827721__F4 In silico method for modelling metabolism and gene product expression at genome scale FRK GPT AMPH PMC5255577__F7 Proposed model for the role of GAS6 in maintaining oral mucosal homeostasis DUOX2 MYD88 FOXP3 PMC9283897__F3 Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis KIF23 CCNA2 PHKA1 AKAP11 HEL-S-84 RAB27A CEP78 CENPF KIN FLNB E2F3 CCP110 UFL1 ATXN10 HSPA4 HMGB3 TES BRIP1 ERBB3 RNF2 CENPE BRCA1 NEDD4 MERTK TMOD3 SIRT1 PCNA TMEM30A FOXM1 TRAPPC11 TOP2A SCYL2 ADAM17 KIF11 FEN1 CHEK2 NUF2 PRC1 RRM1 KNTC2 ASCC1 SCAF11 SLC35A3 PTPN11 USP42 GNS MAD2L1 ATP7B ACAP2 NARG1L RAPGEF6 NEK2 UBR3 KIF20A ANKRD50 SPECC1 CCDC18 TNFRSF10B PDCL3 TUBGCP4 PMC6448793__F3 Ciliary signaling systems within tumors PDGFRA LRP5 MYC LRP6 PTK7 ARHA PLCB1 HES1 DAAM1 SUFU PTCH1 GLI3 BCL2 SMO AXIN2 PMC6224120__F2 Breast cancer signaling pathway PIK3R1 EGF BAD HGF PGR HEL-S-1 EGFR MAPK3 NRAS MAPK14 SMAD4 BCL2L1 MTOR RPTOR TP53BP1 PI3 KDR CASP9 GATA3 EEF2 PARP1 NRG1 EIF4E DIABLO IRS1 CASP3 BIRC2 IGF1 PIK3CA SYK HEL-S-93 STAT3 PMC5143371__F2 Cellular metabolic pathway involved in redox homeostasis ME1 HEL-S-26 HEL-S-64p MTHFD1 MTHFD2 PMC5817809__F1 TKI-induced regulation of glycolytic pathway TIGAR ALDOB ENO3 HK3 FBP2 FBP1 MYC ENO1 PFKL PFKM HEL-S-87p HIF1A HEL-S-49 PFKFB2 ENO2 PFKP PGAM1 HEL-S-133P PGAM2 HK2 HEL-S-281 PMC9313337__F4 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis SOCS2 SOCS3 CISH STAT2 STAT4 SOCS4 TYK2 JAK3 JAK1 SOCS5 SOCS1 STAT3 PMC9313337__F3 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis TYK2 JAK3 JAK1 PMC8745604__F1 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises ME1 NF2 PMC8225793__F5 Mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease MCM2 MAX CDK2 SMC3 IRF9 MDM2 APP SMAD4 IPP MAL PMC9670319__F4 RNA-seq and qRT-PCR analyses reveal the physiological response to acute hypoxia and reoxygenation in Epinephelus coioides GCGR ChAT HEL-S-30 SIK2 F2 PEG10 GIP GNAS POR MTOR GCG PYGL PMC8384902__F5 ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer SMG9 CCNA2 ASCL1 ROCK1 CBFA2T2 JAG2 LFNG DLL3 PROX1 TFDP1 DBF4 HES1 NKX2-1 DDC DBH KNTC2 DLL4 CCNB1 KIF18A B3GNT5 INSM1 PLXNA2 CDC2 BTG2 PTTG1 VRK1 RAD1 RBPJ SET SYT4 YBX1 SNCAIP CENPE DLX5 FOXA2 CDC20 PPP1CC HMMR GIG8 ELF3 UGCG CCNB2 SDK2 HEL-S-93 ZIC5 TF TCF4 PMC5979469__F3 Positive regulation of TERT by WNT signaling pathway specific protein (Beta-catenin) and STAT3; (B) SMAD transcriptionally repressed TERT; (C) BC032469, a lncRNA contained sequences which showed complementarity to miRNA-1207-5p seed regions TERT STAT3 PMC8569443__F1 Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus STAT1 STAT2 IRF7 IRF9 IRF3 TYK2 JAK1 MAVS PMC8745604__F4 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises CSF3 EGFR IL8RB CSF2 CSF1 PMC8745604__F3 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises OGT LATS1 FZD4 RHO JCAD LATS2 PMC3917325__F1 Chondroitin sulfate and HS biosynthesis B3GAT3 CHST11 CSGALNACT1 CHST3 CHST13 XYLT1 EXTL2 CHST12 UST CHST14 CHST7 CHSY3 CHPF CHSY1 CSGALNACT2 B3GAT1 B3GAT2 B3GALT6 FAM20B PMC5432387__F1 Type II Transmembrane Serine Protease Mediated Signaling in Cancer HGF SRC TMPRSS4 RAC1 MTOR TMPRSS2 PMC3660694__F1 Oncostatin M signaling pathway- NetSlim (http://www.netpath.org/netslim/NetSlim_114) map generated to graphically represent the different reactions induced by OSM in various cell types MAPK9 PRKCE SOCS3 MAPK3 CREB1 MTOR CEBPB OSMR STAT1 MMP3 PRKCA TIMP3 PTK2B LDLR SRC CASP9 MAPK1 JUNB EGR1 FOS CDKN1B VEGFA HRAS IRS1 CASP3 RICTOR NFKBIA PRKCB NFKB1 RELA GRB2 JAK3 JUND IL6ST RAF1 SOS1 PRKCH OSM SHC1 PXN STAT3 PMC7238289__F1 Pathophysiology of Alcoholic Hepatitis and Mechanisms of Action of Novel Therapeutic Agents CXCL1 ALB IL22 CXCL8 PMC9615310__F1 Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis HEL-S-61p MTR SQOR SHH pcap PMC5085669__F1 MTOR signaling network in mammalian cells TSC2 ULK1 TSC1 IGF1 EIF4E DEPTOR IRS1 RHEB PMC8977320__F1 Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain GDF6 GDF5 NGF ASIC3 GPC3 BMP7 ASIC4 IGF1 GLI3 MSC AQP2 NOS2 NOTO BDNF ASIC2 PMC10316197__F3 Apoptosis in NAFLD patient RNASEL RNASE1 POLG2 NME4 IRF3 SRSF6 BAX PMC10316197__F2 Inflammation on NAFLD progression TLR4 TLR9 TNF TNFAIP3 IRS1 STAT3 PMC6067120__F4 Schematic representation of estrogen metabolism and AHR signaling pathways AHR CYP1A1 CYP1A2 PMC3740690__F1 Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22 AK2 FOXP3 PMC5522276__F2 HABP2 p.G534E variant in patients with family history of thyroid and breast cancer ISM1 FCHSD1 NDN MAPK3 NCF4 GOLGA4 FLNB MCAM ZFHX4 CDC27 MSH2 ABCC2 NEK1 HSPA4 FKRP TCF3 VWA2 RIF1 ERN2 SEC16A IARS2 TNS1 COL24A1 MYLK CPZ PLXNB2 DHRS2 DYSF OPLAH CS PCK1 PTPRK TTK NAT10 TLK2 ULK2 DNMT3B MYH2 MTA3 LGALS2 SYTL2 PTPN21 CITED4 NKX2-5 LIPG ARL14 HEL-S-30 SKIL AMHR2 DDIT3 GNAT2 MUSK ARL1 PKP4 TRIM24 PMC8345931__F8 Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident AIP USF2 CCL15 CCL24 CCL13 KITLG CXCL17 CCL7 CD80 TNF PPBP PMC8459566__F1 Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to pharmacological modulation PLN HEL-S-62p MPO PLG CRP VWF IRS1 TF PMC3504424__F5 Transforming growth factorB (TGFB) pathway SMAD2 SMAD4 PMC3504424__F4 Tyrosine kinase receptors pathway FOS ATF2 EGFR MYC GRB2 RHO PTEN JUN PMC3502106__F5 Feed-forward signaling in which FGF-9 controls Wnt-2a expression and mesenchymal Wnt/Beta-catenin signaling FGF10 WNT7B BMP4 PMC6214025__F9 Combined nano-therapy strategy of MSN containing DOX and AgNPs in cancerous cell HEL70 NPS XDH MSH2 ERCC2 TOP2A PMC11505109__F2 DNA damage response (DDR) pathway activates the ATM-CHK2-P53 signaling pathway and inhibits CDK2 expression, thereby affecting the G1/S transition WEE1 ATM CDK2 CDC2 ATR PMC3504424__F3 Canonical Wnt-Beta-catenin pathway APC GSK3B PMC8745058__F4 High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling CXCL1 MXD1 FOXM1 PTGS2 MMP9 CXCL10 CDKN3 MYC NCAM1 TOP2A CCNB2 CCL20 ARG1 JUN PMC6687873__F7 IRE1Alpha-XBP1 pathway of the UPR in CF TLR4 IL6 TNF PMC7171093__F7 Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression TLR4 MYD88 STAT3 PMC6221911__F1 Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models NOTCH2 BCL2 PARP1 RNF146 ACHE MTOR BDNF PMC9030253__F4 Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals ATM FADD BAX PMC5458216__F7 Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer SRC PTEN EIF4E MTOR CRK PMC5333385__F2 Proposed biosynthetic pathway of sex pheromone production in female DBM moths (adapted from [, , ]) DES PMC4057789__F1 Cross-talk between EpCAM signaling and the Wnt pathway SOX2 EPCAM APC GSK3B MYC FHL2 PMC3288148__F1 Three pathways contribute to cellular BH4 levels, the synthesis pathway, the salvage pathway and the recycling pathway SPR DHFR PMC7555758__F1 Interplay between neurons and glia in various conditions IGF1 IL33 ARHA BDNF IL1B PMC8145797__F1 Host Factors That Control Mosquito-Borne Viral Infections in Humans and Their Vector AGO2 MYD88 DPT FADD PMC6756887__F8 Graphical abstract of the senescence pathway in Idh2-deficient conditions CDK2 ROS1 PMC4636224__F6 Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis ERBB2 ERBB3 PTEN PMC6232796__F3 mTORC2 in cell metabolism SLC7A5 ACLY HEL-S-133P FOXO1 GLS PMC7886702__F5 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions HEL-S-62p SQLE PTTG1IP S1PR2 CFB PLEC BST2 HAPLN3 CCL5 IL25 TNF CRLF1 IFNG LIMS1 STAT1 SLC52A1 LILRA4 TRIM38 F2 C5AR2 SARM1 AIM2 TRAF4 PMC7886702__F4 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions AGTR1 IRF8 HAPLN3 GBP5 TNF MYH10 MAP2K6 FOXO1 BCL6 STAT1 AGO2 GBP1 LBP PRF1 TNFAIP2 CSF1 UBASH3B PMC8918930__F8 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway NEMF PPP3CC POLR2G GSK3B PHF5A SNRPF MAGOH RPL19 PPIF MRPL16 ARHG GNG4 SART1 PSMC6 ERMN PPP2CA BCL2 U2AF2 PRPF4 PMC4644296__F3 Androgen receptor activation pathways EGFR JAK1 IL6R STAT3 PMC5833788__F7 NIT1 and TGFBeta-Smad2/3 signalling pathway in colorectal cancer SMAD2 SMAD4 TGFB1 TF PMC6668582__F1 Urea cycle pathway OTC NAGS ASL PMC6514070__F3 Cellular pathways and major players for the induction of the immediate early genes egr (a) and c-jun (b), and downstream targets, with focus on pathways previously linked to learning and memory in honey bees [, , , ] F3 EGFR PMC5875170__F2 Regulation of adiposity by mTORC1 ULK1 DEPTOR RHEB MLST8 PMC8586701__F5 Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway TH EGF NGF MAPK8 FOS MAPK3 MAPK14 CREB1 TNF DRD2 CASP3 IGF1 APP BDNF JUN PMC8620939__F3 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy FLCN TFEB MTOR PMC8620939__F2 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy TSC2 ULK1 TSC1 DEPTOR SIRT1 MLST8 PMC5219787__F4 Hedgehog signaling pathway SUFU PTCH1 GSK3B SMO PMC7138402__F5 Schematic model by which RACK1 promotes the progression of OSCC TLR4 CD163 CCR7 CD80 PMC5219787__F3 Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC5219787__F6 Ezrin pathway CD44 RHO PMC5219787__F5 PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways TSC2 TSC1 PTEN PMC3822435__F3 Molecular Pathogenesis of Endometrial and Ovarian Cancer BRCA2 PTEN BRCA1 PMC7123827__F4 3 signals of T-helper cell activation APC CD80 PMC7796397__F2 Two major RNA export receptor pathways, nuclear RNA export factor 1 (NXF1)/nuclear transport factor 2-like export 1 (NXT1) and chromosome maintenance protein 1 (CRM1), are shown, and both are dysregulated in cancer NUP153 RANBP1 NXF3 RAE1 TREX2 TPR NUP62 RANBP2 NXT1 PMC8509622__F3 Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies TRPC6 ARHA NFATC3 PMC9570193__F8 Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease MOS HAL MALL INS GIP LPA CIT CLU MVD HEL-S-11 ADA GAL GRAP RPE GLA MAL PMC6553645__F3 Roles of mTOR complexes in the kidney: implications for renal disease and transplantation PC VCAM1 APC PMC7694322__F1 Melatonin biosynthesis and intracellular signal-transduction pathways activated by stimulation of melatonin specific receptors ASMT MT3 GC PMC7125019__F1 MTOR signaling pathway ULK1 YY1 RHO HIF1A DEPTOR SGK1 MLST8 PMC3174986__F3 Plasmodium falciparum-Infected Erythrocytes and IL-12/IL-18 Induce Diverse Transcriptomes in Human NK Cells: IFNA/B Pathway versus TREM Signaling STAT1 IFIT3 STAT2 IRF9 PIAS1 IFI35 IRF-1 PSMB8 IFNG IFIT1 PMC8333067__F6 Pattern recognition receptors in health and diseases TBK1 TANK TLR4 TRAF3 IRF3 MYD88 TLR3 MAVS PMC11763799__F1 EGFR signaling pathway scheme EGF BRAF EGFR MYC PTEN MTOR STAT3 PMC11763799__F3 RAS triggering processes in cancer cells FOXM1 MYC VEGFA CDK4 CXCL3 IL6 MTOR IRF2 CDK6 PMC9496891__F4 Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases PI3 CCND1 GADD45A PMC4981729__F1 Proposed regulation of HSC quiescence by paternally imprinted DMRs IGF2 MTOR PMC5729527__F2 Scheme of reported cross-talk between core Hippo pathway components and wt (left) or mutant (right) p53 RASSF1 MDM2 LATS1 LATS2 SIRT1 PMC5729527__F1 Simplified version of the key factors within the Hippo signaling pathway LATS1 LATS2 TF PMC7376204__F6 Significantly enriched KEGG pathways for a down-regulated gene set after 24 h CM03 treatment GSK3B PTEN SESN2 MTOR DEPTOR PMC3397482__F2 Map of the VEGF signaling pathway (as an example of an important target in cancer therapy) obtained from KEGG is shown COX2 BAD SRC PMC6937575__F5 The CD38/cADPR/NAADP-signaling pathway SARM1 PMC9179506__F1 Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors PTEN BRCA1 PMC4307931__F1 Collagen XIA1 in cancer promotion MMP3 DDR1 NCL MMP9 PMC3397482__F4 Cytoscape is an open-source bioinformatics software platform for visualizing molecular interaction networks and integrating these networks with other state data RAI1 PMC3418756__F6 Immune activation in the GBS UTI transcriptome comprises prominent cytokine-cytokine receptor signaling STAT1 IL1A STAT2 CXCL10 IL2RG LYN CXCL9 IL10RA PMC3422477__F1 Apoptosis affects cell signaling pathways that control lipid synthesis and energy metabolism TIGAR TSC2 ATM ACLY FASN PMC5588661__F1 Action of metformin on cancer TSC2 TSC1 IGF1 MTOR FASN PMC2245955__F5 Gene expression changes observed in Sema3A signaling pathway L1CAM SEMA7A SEMA5B DPYSL4 GSK3B MICAL1 FYN SEMA6A SEMA3C ARPC1B SEMA3D TUBA8 LIMK1 ACTG2 DPYSL3 CDK5 FES ARPC4 SEMA5A RAC3 PAK1 SEMA6D PLXNA4 ARPC2 ARPC3 WASL RND1 MYLK CDC42 NETO1 SEMA4B SEMA4F ACTA2 ROCK1 SEMA4C NRP2 SEMA4D HEL-68 PLXNA2 NETO2 SEMA3A SEMA4G ACTA1 SEMA3B ARHA RAC1 CRMP1 ARPC5 PS1TP5BP1 RHOD MICAL3 TUBG1 SEMA3E PLXNA1 TUBD1 PLXNA3 SEMA6B TUBG2 MICAL2 PMC3855473__F2 Tax-specific noncanonical NFKB pathway TRAF3 RELB CD40 TRAF2 PMC3855473__F1 Canonical NFKB activation by TCR/CD28 and HTLV1 Tax PIN1 REL MAP3K7IP1 PMC8147357__F1 mTOR Signaling in Metabolic Stress Adaptation TSC2 RICTOR PTEN EIF4E RHEB PMC7756126__F5 Usage of lymphoma B-cell receptor (BCR) antigens for targeting lymphoma BCR SAMD14 ELL PMC11583678__F4 Elucidated mechanism of OMVs APC MYD88 PMC8915915__F2 Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity TLR4 TRADD TRAF6 MYD88 TRAF2 IL1B PMC9179423__F3 Bottom-Up Approach to the Discovery of Clinically Relevant Biomarker Genes: The Case of Colorectal Cancer CASP3 BAD POLK APC GRB2 SMAD4 MSH2 BAX PMC7177420__F1 Harmful effects and mechanisms of alcohol COX2 GFAP CCL2 IL1B PMC3445042__F7 The role of Wnt signaling in hypothalamic progenitor differentiation SOX2 SOX3 GFAP HES1 PMC7051217__F3 Complement factor I deficiency HEL-S-62p CFB CFI PMC7600397__F4 DNA damage response pathway (DDR) WEE1 ATM RAD50 ATR H2AX BRCA1 PMC9699766__F7 lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway HHIP RUNX2 SHH SMO PMC3325426__F1 The miRNA biosynthesis pathway from the nucleus to the cytosol DICER1 DROSHA XPO5 PMC7216814__F7 Network regulation map of downregulated miRNAs, SOX2, and other genes in the platinum drug resistance pathway TNFSF6 ATM APAF1 CASP9 BCL2 MSH3 TOP2A FADD PDPK1 CYCS AKT3 BAX PMC10917885__F1 UST treatments specifically target the IL-12/IL-23 signaling pathway STAT4 UST TYK2 IL23R STAT3 PMC3666582__F7 IDENTIFICATION AND DESCRIPTION OF A NOVEL MURINE MODEL FOR POLYTRAUMA AND SHOCK LBP TRAF6 TYK2 HMOX1 STAT3 PMC5063588__F9 How Thbs4 functions as an intracellular regulator of muscle cellular attachment and membrane stability THBS4 TG PMC3149005__F6 Summary of the UPR pathway in rotavirus infected cells RET ATF4 PMC9609401__F3 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond HEL-S-61p HEL-S-302 DHFR HEL-S-1a PMC9609401__F1 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond HEL-S-61p MAT1A PMC8011569__F4 Analysis of gene pathways for MENT, LH alone or in combination (MENT+LH) to regulate steroidogenesis FDX1 HSD3B1 CYP11A1 HSD17B3 HSD17B8 HSD17B4 CYP17A1 STAR FDXR PMC9403273__F1 Inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models? TLR4 BATF2 TLR9 TRADD RIPK3 TNF FADD TLR3 MLKL PMC3311998__F6 Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate HEL-S-26 CS HEL-S-133P PMC9358977__F2 Immune-mediated inflammatory diseases with chronic excess of serum interleukin-18 NLRP3 NLRC4 HEL-S-52 CDC42 PMC6675034__F4 Full candidate pathway that represents molecular drivers of tumorigenesis in the sarcoma of patient 1 CALCA SLC1A1 ATL1-beta ALK BIRC5 NTRK1 PTGS2 ATF1 PTEN SH3RF1 IL6 CALCB MTOR EIF4EBP1 TOP2A IL6R AURKA EWSR1 CCND1 JAK1 ETS2 ARNT2 PIK3R2 AKT3 PMC2807132__F2 p38 signaling to the chromatin in muscle progenitor cells HMGB1 CDC42 MEF2D PMC7072222__F2 Nucleolar surveillance pathway RPL11 MDM2 RPL5 PMC6935412__F3 Increased IFNB enhanceosome components in lupus B cells STAT1 CGAS TLR7 TLR9 BCR STAT2 IRF7 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 PMC3688817__F8 PPARB Regulates Liver Regeneration by Modulating Akt and E2f Signaling CDK2 CDK4 CDC2 ACLY PMC9285505__F1 Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease PMC6698416__F3 Challenges in deconstructing multicomponent cell responses triggered as a result of uncontrolled RES-exposure KEAP1 PTEN PMC1169236__F2 Metabolic reconstructions of the polyamine pathway based upon pam and sam analyses of poor-prognosis human NE tumors SRM SMS PMC2605486__F4 Olig2 and the transcription factor network controlling motor neuron differentiation IRX3 SOX21 SOX2 SOX3 ISL2 SOX1 OLIG2 ISL1 PMC4128044__F2 MTOR pathway as a therapeutic target TSC2 TSC1 RHEB PMC5889750__F10 The Transcriptional Response of Skin to Fluorescent Light Exposure in Viviparous (Xiphophorus) and Oviparous (Danio, Oryzias) Fishes C1S C4A PMC2605486__F3 Progressive changes in progenitor cells during motor neuron development SOX21 SOX2 SOX3 ISL2 SOX13 SHH SOX1 SOX10 SOX8 OLIG2 SOX9 ISL1 PMC4128044__F1 MTOR pathway is a central regulator of cellular processes PRR5 DEPTOR SGK1 PMC5482185__F5 Diverse cellular functions of arrestin scaffolds MDM2 BCL2 PMC4749494__F5 The effects of extracellular CypA and MM284 in experimental BA MMP7 TIMP1 TIMP4 TGFBR1 SMAD4 PMC8664591__F1 Appetite Regulation of TLR4-Induced Inflammatory Signaling POMC NPY CRH MC4R TRH ARC PMC4826392__F3 The dynamics of TET-mediated cytosine oxidation and its impact on DNA methylation patterns on regulatory elements in vivo TDG TET3 TET2 TET1 PMC4826392__F2 Pathways of DNA demethylation mediated by TET enzymes TDG TET3 GC UHRF1 TET2 TET1 PMC7551039__F1 Immune checkpoint-mediated T-cell inactivation APC ZAP70 BTLA CTLA4 TIGIT LAG3 PMC9230919__F1 Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile ChAT MTR DHFR MTHFD1 PMC5398990__F3 Schematic overview of underlying pathophysiology and targeted therapies in neurofibromatosis 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNSTs) NF1 MTOR CDKN2A AURKA PMC8065873__F2 Anti-metastatic mechanisms of herbal medicine in colorectal cancer: Herbal medicines suppress angiogenesis, migration and invasion via inactivation of diverse HIF-1A pathways VEGFC CCR2 IGF1 ERBB2 CXCR4 EGFR GSK3B VEGFA SRC CCL2 CDC2 CXCL12 PMC8065873__F1 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery VEGFA MTOR VEGFC KYNU CDK2 CXCR4 SRC SP1 H2AX PCNA STAT3 CDC42 BAX PMC5612509__F1 Complement-mediated haemolysis in chronic cold agglutinin disease and cold agglutinin syndrome HEL-S-62p PMC8944968__F3 Circular RNA ITCH: An Emerging Multifunctional Regulator APC GSK3B ITCH PMC8065873__F5 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery CXCR3 CS PLG VCAM1 EGFR CCR7 CDC2 CDH2 RPE IL1B STAT3 PMC8065873__F4 Anti-metastatic mechanisms of herbal medicine in liver cancer: Herbal medicines interrupt signaling transduction and EMT cascades related with cancer cell migration and metastasis DLX2 RGS5 CXCR4 WT1 MTOR STAT3 PMC8065873__F3 Anti-metastatic mechanisms of herbal medicine in gastric cancer: When it comes to ROS, it has double-edged aspects in anti-tumor efficacy and mechanisms GPX4 MPO CCND1 CDH2 CDC42 PMC11629574__F8 Schematic diagram showing the yes-associated protein 1 (YAP1) as a critical molecular pattern for diabetic kidney disease (DKD) PINK1 CXCL1 YAP1 CXCL6 CCL19 LATS1 IL6 LATS2 TFAM PMC2648620__F2 Insights into the Roles of Gut Microbes in Obesity CCL2 MYD88 JUN IL1B TIRAP STAT3 PMC4974519__F1 The induction of ER stress and UPR during coronavirus infection ATF4 EIF2A XBP1 PMC8521937__F4 Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy MAF KEAP1 NEDD8 RBX1 UFD1L PMC2733092__F4 Intersection sets of the differentially expressed miRNAs constitute complex interaction networks.A Venn diagram illustrating the production of intersection sets from three miRNA target prediction algorithms RUNX2 MYC RFX1 VEGFA PBX1 PPARG SOX6 MYOD1 SOX9 BMP4 PMC6604516__F7 Graphical signalling pathway of the effect of APPBP2 on NSCLC via PPM1D and SPOP.The blue lines indicate the activation of the targets according to our experiments or published researches PPM1D APPBP2 CDK4 SPOP PMC3394800__F5 Developmental Changes in the Metabolic Network of Snapdragon Flowers SHD CS IPP PMC3394800__F4 Developmental Changes in the Metabolic Network of Snapdragon Flowers RPE HEL-S-162eP PMC4026703__F1 Schematic diagram showing the central role of the BMP6-HJV-SMAD signaling pathway in hepcidin regulation and the proposed interaction with other hepcidin regulators TWSG1 EGF BMP6 HGF GDF15 TMPRSS6 HFE MTOR SMAD1 DKFZp781O1323 TFR2 PMC7151129__F1 The retinoic acid signalling pathway during development RDH10 DHRS3 PMC3394800__F7 Developmental Changes in the Metabolic Network of Snapdragon Flowers CS PSPH PMC8920937__F8 TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway CASP3 BAD TMBIM1 BAX PMC3840081__F2 Estrogen-induced ER-mediated pathways of vascular relaxation GC ARHA PMC3108474__F2 Membrane type-MMPs regulate vascular cell signaling in cancer MMP2 MMP9 SRC HBEGF MTOR PMC9228236__F4 Assessing Gene Expression Related to Cisplatin Resistance in Human Oral Squamous Cell Carcinoma Cell Lines MPZ RHOD CNTN2 MAFK DROSHA CD44 CDH2 PMC3632219__F7 Proposed roles of PLCB1 in degradation of endocannabinoids at implantation sites COX2 FAAH PLCB1 PMC9428582__F2 Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies FBL PGM3 FTH1 OGT EGFR TFRC SLC29A1 HMOX1 CLU PMC9084533__F8 Role of OPTN on myogenesis during muscle regeneration APC GSK3B OPTN MYOG PMC2963118__F2 HRS cell and its cellular microenvironment STAT1 CCL5 IFNG PMC3736507__F2 Schematic diagram showing that cartilage matrix homeostasis is adjusted dynamically by TGFB signaling pathway SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC5641113__F9 Genome-wide functional analysis on the molecular mechanism of specifically biosynthesized fluorescence Eu complex ANGPT2 KIT BAD MEI1 HEL2 ATF2 PTEN RAC1 EIF4E MTOR RHEB RXRA PI3 BCR IL2RG PKN2 MDM2 SYK EIF4B CYRIA RBL2 CD19 PMC8059100__F8 Schematic presentation of possible mechanism of VERU-111 in CxCa BAD TIMP1 CDK4 CDC2 STAT3 PMC6216000__F1 Radiation and tyrosine kinase inhibitor resistance EGFR GRB2 MTOR PMC4714660__F1 Human dendritic cell (DC) response to Toll‐like receptor (TLR)2/3 adjuvants BATF3 HMGB1 TBK1 TLR5 TLR9 IRF3 MYD88 TLR1 CD8A TLR10 TLR3 TLR8 TLR7 TLR4 PMC4383269__F9 Human Papillomavirus 16E6 and NFX1-123 Potentiate Notch Signaling and Differentiation without Activating Cellular Arrest HES5 NOTCH1 LORICRIN HES1 PMC11532153__F3 Functions of p120-catenin in physiology and diseases TLR4 ARHA IRF3 MYD88 TIRAP PMC9646812__F4 Transcriptomic profiling analysis to identify genes associated with PA biosynthesis and insolubilization in the late stage of fruit development in C-PCNA persimmon PDC CS ALDH2 PMC3219972__F3 Effect of carbon exchange and reversibility constraints ADA TNLG7C CPD PMC7484971__F8 KEGG enrichment graph: miRNA-4534 is involved in the FOXO signaling pathway IL10 EGF ATG12 EGFR GOPC SMAD4 PTEN INSR NLK ATM CDK2 MDM2 IL7R KLF2 BNIP3 REL SKP2 STAT3 PMC5664079__F3 PDK1 and the Salvador/Warts/Hippo (SWH) pathway LAT PMC2094129__F2 Respective balance between Gi- and Gs-dependent signalling pathways and their roles in the modification of FcARI-mediated mast cell degranulation BTK FYN LYN SYK LPA PMC5664079__F1 Major signaling pathways in chemoresistance and PDK1 implication MTDH CAMKK2 PMC7110753__F3 Hypothesized dauer signaling during N IGF1 PPM2C ADA PTEN SKI SGK1 NCR1 PMC10779870__F11 KEGG TNFA signaling and its association with the PI3K-AKT signaling pathway TRAF3 TNF TRAF2 PMC4240841__F1 Proposed model of Ostf1 in fishes ROCK1 GCK BMP4 PMC7956578__F2 Impact of hypoxia pathway proteins on immune cells and cancer stem cells, and their impact on the development of the tumor EGF HGF TNF PMC10779870__F13 Proposed molecular effects of fucoxanthin through modulation of genes and proteins of the PI3K-AKT signaling pathway in TNF-Alpha-stimulated MDA-MB-231 and MDA-MB-468 cells PDK2 MAPK3 ARHA EIF4EBP1 HRAS EIF4B IRS1 FOXO1 TIRAP PMC4714660__F4 Cell death pathway in tumor cells CYLD PGAM5 COMP FADD TLR3 MLKL PMC7218030__F3 Partial action pathways of H2S donors and their derivatives on TNBC CASP3 FOXQ1 CASP9 MTOR PMC6400837__F1 Notch pathway promotes drug resistance by regulating cancer cell survival, glycolytic switch and cancer stem cells RBPJ HEXA PDK2 JAG2 MYC ENO1 PFKM HEL-S-87p HES1 IGF1 DLL4 ABCC1 BCL2 HEL-S-133P HK2 STAT3 PMC8213345__F3 Interplay of Forces and the Immune Response for Functional Tendon Regeneration COL1A1 TNMD CFTR PMC3362209__F1 RIP-1 in programmed necrosis CYLD PROC FADD TAB3 PMC5511947__F1 The downstream signaling cascade initiated by a hypoxic microenvironment TWIST2 SOX2 EPCAM TWIST1 ZEB2 CXCR4 CD44 BMI1 ABCG2 CDH2 PMC7349551__F1 Wingless and Int-1 (WNT)/Beta-catenin signaling pathway LRP5 LRP6 PMC11715087__F9 Working model summarizing key conclusions from this study NAXD PHGDH HAP1 PMC9266842__F2 Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer IGF1R EGFR PTEN MTOR SKP2 PMC9664149__F6 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation NOG MPO CRP GPX1 PMC3393131__F1 Wnt/Beta-catenin signaling in T cell immunity and cancer immunotherapy PROP1 APC TEF SATB1 LRP5 LRP6 BCL9 PMC4166520__F1 ATX-LPA Receptor Axis in Inflammation and Cancer SI ARHA LPA CDCA2 PMC9664149__F8 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation MPO CRP ACE2 PMC6433792__F1 Phosphodiesterases (PDEs) in the pituitary gland: After stimulation of somatotroph cells via GHRH, the G protein coupled receptor is activated, which causes a conformational change of the receptor PDE4D AIP PDE4A GHRH PMC3573097__F7 Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma RIOK2 RIOK1 EGFR PMC3949429__F2 Two major signaling pathways activated by HBV and HCV in hepatocarcinogenesis BAD IGF1 APC GRB2 SRC IRS1 PMC9297740__F1 PARP Inhibitors in Glioblastoma and Perceiving Challenges as Well as Strategies for Successful Clinical Development MSH6 MSH2 PMC4083841__F1A Beta-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis EPOR EPO PMC9550229__F2 Screening and validation of nickel ion cytotoxicity biomarkers based on transcriptomic and proteomic technology CAD CSF1 CRK LAT VAV2 PMC4674888__F9 Development WNT signaling pathway Part 1 APC GSK3B RBX1 TCF4 SKP2 PMC4674888__F8 Development Hedgehog Signaling which is the top scored pathway map in MetaCore enrichment analysis results DHH BOC NUMB CDON IHH DISP1 CDC37 GAS1 KIF27 RBX1 SAP18 SUFU PTCH1 GLI3 SHH SPOP ADRBK1 SKP2 PMC8047077__F7 IFI6 mediated inhibition of HBV replication and gene expression STAT1 STAT2 PMC5880536__F2 Gut microbiota and IBD: causation or correlation? IL16 AHR TNF IL1B IFNG PMC4132784__F7 Mechanism by which the PTEN-PI3K-AKT-MDM2 signaling axis exerts control over HIF1A degradation in cytoplasm under hypoxic conditions via the MDM2 E3 ligase and 26 S proteasome PI3 MDM2 VHL PTEN RBX1 PMC11008728__F2 Fine-tuning tumor- and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients CXCL10 APC CXCL9 CD80 CXCL11 PMC8198195__F5 Resolving the Contradictory Functions of Lysine Decarboxylase and Butyrate in Periodontal and Intestinal Diseases HBD L2HGDH PMC11490609__F4 MAPK pathway activation in zccs1703 NF1 FGFR1 KDR BRAF FRS2 GRB2 VEGFA CCND1 CDK4 SOS1 CDK6 PMC10779157__F3 SHP-1-mediated inhibition of the JAK/STAT signaling pathway STAT1 EPOR EPO STAT2 TYK2 JAK1 PMC8147772__F3 Control of Macrophage Inflammation by P2Y Purinergic Receptors STAT1 TLR4 MYD88 PMC8147772__F2 Control of Macrophage Inflammation by P2Y Purinergic Receptors TLR4 MYD88 ADAM17 PMC3602989__F2 Leptin and cancer: Pathogenesis and modulation STK11 LEPR CRTC2 PMC8294041__F8 Cancer Preventive and Therapeutic Potential of Banana and Its Bioactive Constituents: A Systematic, Comprehensive, and Mechanistic Review EGF EGR1 EGFR GRB2 ATF3 BAX PMC5739444__F7 SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation SIRT2 RHO PMC6585406__F1 OAS/RNase L pathway RNASEL OASL OAS1 OAS2 OAS3 PMC8534193__F1 Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma AFP ZHX2 PMC6888217__F3 Extracellular ADO on subsets of macrophages CD163 CD80 CD68 PMC6888217__F1 Extracellular and intracellular (canonical and non-canonical) adenosinergic pathways ENPP1 PIR ADA PMC3196095__F6 Proposed model CD14 TLR4 LBP NR1C1 PMC2605641__F2 Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration GCLM GCLC PRX NQO1 PMC9058032__F5 Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking TH SOCS3 DAO LIF PROC TRAF3 FES TNF POR NOD2 MMP14 HEL-S-11 BIN1 TRAF2 SELE PMC4125705__F4 Phenylpropanoid biosynthetic pathway in Ocimum sps CS CAD PMC3610375__F1 The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus IL10 IL4 PMC3969997__F7 The hypothetical signaling pathway in pathological angiogenesis regulated by interactions of activated VEGFR2 and EPOR EPOR VEGFA STAT3 PMC2542903__F6 Proposed EphB2 signaling network ABL2 USP15 DOCK4 ABI2 SHB DDR2 UBB CYFIP1 NEDD4 PMC9226676__F2 Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications PMC5766282__F12 Novel Role of the Nociceptin System as a Regulator of Glutamate Transporter Expression in Developing Astrocytes JAK3 MTOR PMC2995293__F2 Immune and central nervous systems interact and contribute to the etiology and pathophysiology of cytokine-induced depression CRH CRP IL2 WAS BDNF IL1B PMC12165645__F1 Simplified overview of ISGs and their actions in kidney diseases ISG15 OAS1 ISG20 TEC IFIT1 PMC7511443__F4 MC5R signaling pathways STAT1 PLIN1 PMC12165645__F2 Therapeutic agents targeting ISGs ISG15 IRF7 ISG20 IRF9 IRF3 PMC4153031__F2 The hypothetical estrogen-induced signaling pathway in neurons MAP1B APP PMC8866817__F4 CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer TNF FADD PMC3386525__F3 The signalling transduction pathways involving the tuberous sclerosis proteins, hamartin and tuberin RHO EIF4E MTOR RHEB PMC7916982__F9 Iso-Alpha-acids can exert anti-inflammatory activity by inhibiting the NF-kB pathway by acting on several kinases involved upstream and downstream of the signal transduction BTK BMX SYK MYD88 TNF IL1B MAL PMC7933481__F1 Anti-inflammatory effects of increased global SUMOylation in the intestine NLRP3 CXCL16 CCL11 IL27 CCL20 IL17A IL22 CXCL9 CCL5 IL6 CXCL12 PMC2696288__F7 Protein Acetylation Microarray Reveals NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis PC PCK1 SIRT1 PMC4464175__F5 Lipid biosynthetic pathways and interactions of phospholipid synthases and proteins involved in cell division DGKB LTA PGP LPA LPP PSD DGKA PMC6036613__F3 NFKB pathway induced by LaW37 in Caco-2 cells EGF NGF WNK1 RELB PLCG2 TNF MAP3K7IP1 CARD11 LTA RELA LCK ZAP70 CD40 TGFA LTBR PMC3075645__F8 DNA damage-triggered activation of SAPK/JNK at late times following cisplatin treatment ATM BRCA2 XPC XPA RHO ATR PMC6722208__F1 Circadian regulation of hepatic gluconeogenesis illustrates an example of bi-directional regulation between clock genes and metabolism NAMPT PCK1 SIRT1 FOXO1 PMC7140515__F1 Crucial signaling pathways in CCA metabolism SIRT2 HDAC3 PDHA1 PTEN SIRT1 FOXO1 UCP2 PMC5343750__F1 Are Circulating MicroRNAs Peripheral Biomarkers for Alzheimer’s Disease? AGO2 DROSHA RAN PMC10583183__F11 Mechanism that HRF prompts pyroptosis via CaSR/NLRP3/caspase1 signaling pathway under MI/R conditions NLRP3 CASR GSDMD PMC3593087__F1 Pro-osteoblastogenic signal transduction by insulin and IGF1 receptors IGF1 GRB2 PTEN PMC3593087__F3 Cross-talk between insulin/IGF-1, BMP2, and Wnt signaling pathways RUNX2 ALK BMP2 APC SMAD4 PTEN IRS1 NR1i1 IGF1 IBSP GRB2 SMAD1 TF DKFZp781O1323 PMC7180223__F1 Gene ontology (GO) analysis of LOAD risk factors reveals the enrichment of genes in the trafficking pathway CD33 NYAP1 CLNK ABI3 CR1 CLU SLC24A4 SORL1 ZCWPW1 INPP5D KAT8 BIN1 PTK2B EPHA1 HESX1 FERMT2 MS4A2 PICALM CD2AP APOE SCIMP ALPK2 HLA-DRB1 ADAMTS4 SPI1 MS4A6A ADAM10 APH1B WWOX PMC2945784__F2 Cancer signaling pathways affected within the tumor EGF EGFR SOST PTEN EIF4E RB1 MTOR HRAS NRTN PDPK1 RPTOR RET PDGFA RAF1 SOS1 NKX3-1 PMC10556387__F2 Neuroprotection targeting to signal transduction of apoptosis, necroptosis, and autophagy in ischemic stroke RIPK1 RIPK3 ATG14 TRPM7 FADD MLKL BAX PMC10556387__F1 Neuroprotection targeted to oxidative stress and induced mitochondrial dysfunction and ferroptosis in ischemic stroke GPX4 LPCAT3 FACL4 KEAP1 PMC3356304__F6 Personalized Pathway Enrichment Map of Putative Cancer Genes from Next Generation Sequencing Data TP63 EGFR PTEN PMC4055840__F5 Hypothetical model illustrating possible molecular mechanisms underlying the action of the glucocorticoid receptor in the excitation-inhibition balance in NPCs CORT EGR1 BDNF PMC8445921__F5 Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis TH ASL PMC4344782__F11 Overlapping Alzheimer-related protein association network of AD-iPS5 neurons and of AD-iPS26B neurons GSK3B COX7A2 HSD17B10 APP COX6A1 COX7B NDUFB6 COX7C NDUFB5 SDHA SNCA NDUFS4 NDUFV2 NDUFA7 NDUFAB1 COXFA4 NDUFC2 HEL-S-162eP CALM1 NDUFA2 NDUFA3 NDUFB7 NDUFB3 CYC1 ATP2A2 PMC8543024__F3 Adenomyosis pathogenesis: insights from next-generation sequencing GRB2 PMC4344782__F10 Alzheimer-related protein association network in AD-iPS26B neurons GSK3B COX7A2 UQCRFS1 NAE1 UQCRC1 APP COX6B1 COX6A1 COX7B NDUFS5 NDUFB6 COX7C NDUFB5 SDHA SNCA NDUFS4 NDUFV2 NDUFA7 NDUFA6 NDUFB2 NDUFAB1 COXFA4 NDUFC2 HEL-S-162eP CALM1 NDUFA2 UQCRH NDUFA3 NDUFB7 NDUFB3 CYC1 ATP2A2 PMC3140692__F3 Hypoxia regulates other critical pathways that impact tumor progression in a HIF-independent fashion TSC2 PML EIF2A EIF4E RHEB PMC5524075__F7 Interleukin (IL)‐13RA1 in myocardial metabolism CS PC FH APC MAL PMC3757391__F1 Maintainance of DNA Methylation MBD4 TDG ATM ATR DNMT3B FADD TET1 PMC9243104__F7 Graphical abstract of WASp:RPA alliance in genome stability TOPBP1 ETAA1 WAS PMC5817862__F2 TKIs inhibit TKs-mediated signaling pathway GRB2 PTEN MTOR PMC8081290__F3 Integrated working model of key metabolic signaling axes in macrophages (Mфs) during ischemic organ injury and repair NLRP3 TLR4 MERTK MTOR CIT IL1B CD36 PMC8944338__F4 Multi-protein complexes contribute to the Stimuli-Sensing Channels intracellular signaling pathway CLCN3 SLC17A3 CLCN7 STOML3 TRPM5 TTYH2 TRPA1 TTYH3 TTYH1 TRPV1 PMC8944338__F3 Protein-protein interaction network for the AGE-RAGE pathway PIK3CD PIK3R1 PRKCZ MAPK9 THBD AGTR1 MAPK8 MAPK3 SMAD2 MAPK14 SMAD4 CCL2 PRKCA STAT1 MAPK12 MMP2 MAPK1 IL1A MAPK10 VEGFA TNF HRAS CYBB PIK3R3 PLCB4 EDN1 VEGFC MAPK13 PRKCB VCAM1 BCL2 MAPK11 TGFB1 AKT3 CDC42 PLCG1 PRKCE TGFBR1 VEGFD TGFBR2 NOX4 COL1A1 PIM1 F3 PLCE1 COL1A2 CCND1 PLCD3 IL1B SELE BAX EGR1 NFATC1 RAC1 IL6 CASP3 AGER NFKB1 RELA PIK3CA VEGFB PIK3R2 STAT3 PMC5362340__F1 Kinase signaling and targeted therapy for primary myelofibrosis PAK1 HEL-S-99n ARHA HCTP4 CDC2 C13orf34 MPL AURKA STAT3 PMC3258586__F1 PI3K pathway activated by EGF-stimulated EGFR or by the constitutively activated EGFRvIII EGF EGFR SRC PTEN MTOR PMC10979751__F3 Macrophages in osteosarcoma cell proliferation and metastasis EGF ARG1 TGFA STAT3 PMC10957566__F2 Protective effect of the Notch signaling pathway on B cells under irradiation exposure PREB SI PAX5 FURIN PMC8169418__F1 Effect of COVID-19 on NFKB and Neurological Manifestations of Disease TLR7 ACE2 TLR3 TMPRSS2 PMC9511411__F5 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy COPA TREX1 PMC9511411__F4 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy TBK1 STAT1 STAT2 IRF3 TYK2 JAK1 PMC8984481__F1 Escaping Death: How Cancer Cells and Infected Cells Resist Cell-Mediated Cytotoxicity RIPK1 TRADD SHARPIN RIPK3 TNF TRAF2 CASP8 FADD MLKL BAX PMC9511411__F7 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy DNASE2 TREX1 FCGR2B MYSM1 PMC4028619__F1 Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma HEL-S-61p HEL-S-182mP PMC9669583__F3 8p11 myeloproliferative syndrome: Genotypic and phenotypic classification and targeted therapy STAT1 TSC2 FRS2 GRB2 FOXO1 STAT3 PMC3411062__F1 Network pathways analysis of molecules identified in T-cells that are involved in LFA-1/ICAM-1 signaling SPSB1 RBPJ MAP2 SKIL CD6 CDKN3 JAG2 SPRY1 MCM7 SMURF1 FLT3LG BCOR IDO1 BMPR2 MAP2K1 CDKN1A SMURF2 MLLT3 TGFA PMC3075510__F9 Phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3 (GSK3) signalling is required for expression of a subset of interleukin-10 (IL-10) inducible genes SOCS3 ARNT2 STAT3 PMC5449086__F8 Schematic model of the regulatory role of ADAR1 in liver homeostasis IRF3 CCL5 IL6 CCL2 MAVS PMC8797391__F9 Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma FER GAL MAL PMC6280705__F1 General eukaryotic translation initiation pathway ELF2 EIF5B ELF5 ELF3 EIF2A EIF4E EIF5 PMC6527392__F10 Atypical PKCs control actin cytoskeleton via Cofilin activation EGFR SSH2 PTEN SSH1 PMC6892198__F1 Retinoic acid (RA)-signaling pathway CYP26A1 CYP26B1 CYP26C1 ALDH1A3 RBP4 HEL-S-53e RDH10 ALDH1A2 RDH5 ADH7 PMC10135819__F2 Diagram illustrating RET and RET-regulated NAD+-dependent sirtuin signaling pathway as a contributor and potential therapeutic target for aging, age-related diseases, and ischemic stroke RET NDUFS3 PMC8201404__F2 GIMAP Family Proteins: An Incomplete Puzzle TSC2 TSC1 GIMAP5 LCK GSK3B ZAP70 GRB2 JAK3 JAK1 MTOR LAT RHEB PMC7866155__F1 Targeted Neoadjuvant Therapies in HR+/HER2−Breast Cancers: Challenges for Improving pCR NODAL MDM2 BCL2 CDK4 PTEN CDK6 PMC7438278__F7 Working model for induction of cardiomyocyte necroptosis by Cops8 deficiency RIPK1 RIPK3 BCL2 CASP8 MLKL PMC6121276__F2 Catabolic and pro-inflammatory signaling in osteoarthritis FGFR1 MMP2 SMAD2 FGF2 MMP9 SMAD4 ACAN COL2A1 SMAD1 IL1B DKFZp781O1323 CTGF PMC11953998__F22 Design strategies for nanodrugs targeting the mitochondria and lysosomes NPS FAP CUTA PMC3977945__F3 Ubiquitination-mediated regulation of the core Wnt/Beta-catenin pathway components ZNRF3 USP15 RNF43 CYLD USP14 SMURF2 APC LRP5 LRP6 HECTD1 SMURF1 RNF148 PMC3977945__F2 Simplified phosphorylation-mediated regulation of the core Wnt/Beta-catenin pathway components NLK dik HIPK2 TNIK APC LRP5 LRP6 PMC3977945__F1 Simplified Wnt/Beta-catenin pathway APC LRP5 LRP6 PMC5381727__F2 Roles of Caspases in Necrotic Cell Death NLRP3 HMGB1 IL16 NLRC4 AIM2 IL1B PMC7264424__F8 Calcium signaling pathway PLN BCR STOM HRC MCU TRDN CP PMC8297384__F1 Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy CXCL1 SOCS3 CD46 CD163 CXCL2 CD80 LAG3 ICOS PMC5826825__F2 Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development DSC2 PSCA OFD1 PMC8074600__F2 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder DHH IHH SUFU PTCH1 GLI3 SHH SMO PMC8074600__F1 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder CDH8 APC LRP5 LRP6 BCL9 PMC3589553__F3 Regulatory mechanisms for the Hippo pathway PATJ AMOT PALS1 APP AJUBA SCRIB LATS1 RHO PMC8339349__F7 lncRNA H19 facilitates the proliferation and differentiation of human dental pulp stem cells via EZH2-dependent LATS1 methylation LATS1 EZH2 PMC6134813__F4 Pathways Involved in Ovarian Epithelial Cancer GPR17 FOXM1 CXCL10 CENPE PTGER3 GNGT1 CNR1 CDCA8 PDYN CXCL13 NPW NUF2 SKA1 CXCL9 MCM10 CXCL11 SPC25 PMC11953998__F24 Synthesis process for the polymer DBD and the formation of NP-DBD nanoparticles TBK1 CGAS PMC3418849__F10 TrkA signaling pathway BAD MAP2K1 MAP2 NGF MAP2K4 FRS2 GRB2 SRC MTOR CRK MAP2K6 FOXO1 PMC4209203__F10 Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia MAML1 SET NOTCH1 JARID2 EZH2 FBXW7 SUZ12 EED PMC4859987__F1 Terpenoid indole alkaloid pathway INMT IPP PMC2989631__F1 DNA damage response (DDR) pathway RNF168 HERC2 RNF8 ATM MDC1 BRCA1 PMC11055915__F4 Mitochondrial quality control regulates cell death induced by copper and iron MFN1 GPX4 FDX1 LPCAT3 TRADD FACL4 FES RIPK3 GSDMD NLRP3 PDC MFN2 RIPK1 DLAT MLKL PMC8632002__F2 Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 TLR7 IRF7 SLC15A4 MYD88 TASL PMC11187369__F4 Druggable toll-like receptor (TLR) cascades TLR8 BTK TLR7 TLR9 EEA1 MYD88 TIRAP PMC4376477__F1 Neuronal aggregates: formation, clearance and spreading HSF1 PMC7177938__F4 Gene-Ontology (GO) term enrichment and pathway term network analysis of DEGs shared by ADJ versus PRE and ATT versus PRE lists (1928 DEPs) POLE HP HEL-S-11 PROC RHO PMC7865703__F2 STAT3 pathway activation represents a focal point of tumorigenesis and immune escape EGFR BCL2 CD80 CCL2 FOXP3 PMC10216286__F1 The TRAIL apoptosis pathway FADD BAX PMC7381302__F1 Extrinsic apoptosis execution HEL-S-62p BAD C9 C6 BCL2 FADD BAX PMC4618842__F1 Pathogenesis of Muscle Wasting in Cancer Cachexia: Targeted Anabolic and Anti-Catabolic Therapies ELF2 IGF1 EIF4E MTOR PMC10216286__F2 TRAIL resistance FADD BAX PMC5615369__F1 Novel aspects of tumor biology and translational approaches using zebrafish models TWIST2 RAG2 GATA3 PMC7191626__F1 Enzymatic cascade involving the renin-angiotensin system, key receptor systems, and biological effects ACE2 PMC6997470__F2 PAMPs exposure regulation in response to environmental signals TLR9 ACE2 IL1B NOD2 CCL3 PMC3329953__F8 mTOR pathway in aging TSC2 TSC1 EEF2 GSK3B EIF4E MTOR RHEB MLST8 PMC11554632__F1 Outline of force-sensing proteins in cardiovascular system PIEZO1 CCND1 CDK4 MTOR PMC9013808__F3 cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal AKAP7 PMC6770909__F1 Redifferentiation of thyroid cancer PIGU RET BRAF TSHR PTEN MTOR TTF1 PTTG1 PAX8 PMC3218743__F2 Inflammation in the gouty joint NLRP3 MYD88 ATR PMC6780401__F3 Impacts of mutations in the TGFB signaling transduction components contribute to PDAC development BMPR2 TGFBR1 KLF10 WAS SMAD1 ADM TGFBI PMC4266469__F1 Schematic demonstrating the effects of AMPK signaling in stroke BAD F2 PMC6447777__F2 Candidates of miRNA-based therapy against perinatal hypoxic-ischemic brain injury TLR4 MSC FGF2 REST ARHA IRAK4 PTEN PTGDR PMC7501671__F8 EMfC action in amelioration of inflammatory response and autophagy pathway during anti-hepatic steatosis in HFD-induced obesity mice ATG12 ATF4 EIF2A MTOR PMC8498116__F1 Targeting the Integrated Stress Response in Cancer Therapy ELF2 ATF4 EIF2A PMC2635018__F1 Amino acid transporters and nutrient sensing mechanisms TSC2 IRS4 TSC1 PTEN IRS1 RHEB PMC8221367__F1 Canonical Wnt Signaling Pathway and Tcf1 APC GSK3B LRP5 LRP6 AXIN2 PMC6050436__F5 MapMan overview of general metabolism for the metabolites and proteins/transcripts of Quercus ilex OMA1 GIP CIT PMC2805685__F11 Reconstruct part of KEGG pathway by our method STAT1 RUNX1 ATF2 EGFR BCL2 YY1 ALG10 HSF2 E2F3 PMC4829595__F3 Representation of the cross talk among different pathways under water-deficit conditions TH SNRK LIPN PMC6520274__F1 Hydrogen sulfide intervention in cystathionine-Beta-synthase mutant mouse helps restore ocular homeostasis HEL-S-61p MTR CS PMC6616371__F3 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing LEF1 APC GSK3B RYK ROR2 RHO DKK1 CDC42 PMC6813538__F8 Action of EC-7072 targeting the BCR signaling pathway in CLL cells BTK BCL10 LYN BCL2 PLCG2 CD79A CD19 PMC1785270__F6 A model illustrating the positive and negative regulation of PanK2 activity PANK3 CPT2 PPAN PANK2 PANK1 PMC7090043__F2 Context is everything: extrinsic signalling and gain-of-function p53 mutants MDM2 ARHA HSF1 PMC6616371__F4 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing GRB2 RAF1 PMC5108756__F2 Inhibition of the complement system by pathogenic fungi HEL-S-62p PLG GPD2 PMC8401727__F5 Physcomitrium patens Infection by Colletotrichum gloeosporioides: Understanding the Fungal–Bryophyte Interaction by Microscopy, Phenomics and RNA Sequencing ERG HEL-S-11 PMC7947196__F1 Microglial metabolic programming and immune functions in AD HIF1A MTOR IL1B PMC1351030__F8 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras EGR1 KLF5 CCND1 HRAS PMC11082748__F4 Graphical representation of the CREB signaling pathway downregulated in the control group (see Figure 3A) CREBBP MAPK12 EP300 TBP CAMK4 RPS6KA1 GRB2 MAPK1 RAF1 SHC1 GTF2B PMC3928130__F2 AMP-activated protein kinase (AMPK) beyond metabolism ATM CDK2 RAD50 H2AX MRE11A PMC3928130__F4 AMP-activated protein kinase (AMPK) beyond metabolism ATM SESN2 RHEB PMC11082748__F5 Genes (N = 21) detected by IPA as involved in the neuroimmune pathway were entered into a representation using the GeneMANIA algorithm HMGB1 PIK3R1 ACVR1 CTSS CX3CR1 FOS TICAM2 ICAM2 FPR1 CSF3R MAPK14 MYD88 MAP2K3 CYBB ICAM4 TYROBP CSF1R MAPK13 B2M IFNGR1 HMGB2 MEFV PYCARD PMC4019832__F2 Activation, signalling and targeting of ErbB receptor family members FOS MYC GRB2 PTEN MTOR JUN PMC7504480__F1 eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases NLRP3 HMGB1 TLR4 IRAK1 TRAF6 IRAK4 MYD88 IL1B PMC3334466__F1 Duo/Cdc42 pathways PAK1 LIMK1 CDC42 PMC4287105__F3 Example of difference between LW and MS at fetal gestational age 110: pathway of Gluconeogenesis ALDOB ENO1 GCK DLD HEL-S-162eP PC PKLR MPC2 PCK2 PFKP HEL-S-133P DLAT PGAM2 HK2 PMC3928130__F1 AMP-activated protein kinase (AMPK) beyond metabolism TSC2 YY2 PMC8500332__F8 n-butyrate alters the RAP1 signaling pathway in the endometriotic epithelial cells RAD1 CAD LAT PMC8743870__F8 Triaging Down the 2021 Chest Pain Guidelines CAD PMC11811495__F3 Example of network visualization from the KEGG Pathway database for the “Wnt signalling pathway” (https://www.kegg.jp/pathway/hsa04310), analysed using Orthoweb MCC NR1C2 RYK SENP2 APC2 FZD10 PMC5527809__F2 Interaction network and subcellular localization of differentially regulated genes by dasatinib in K562 cells SOCS2 ERMAP ARHH SOCS3 MAFF HECW2 PDE4DIP MYC IER2 PHLDA1 ATF3 XBP1 CD69 CISH IKZF4 HHEX PMC6463957__F5 Hub genes and module analysis of the PPI networks SPARC MUC1 COL18A1 Meflin COL3A1 ACTN1 B3GNT6 HEL-S-53e ADH7 GCNT1 SERPINA4 COL1A1 UGT2B15 TIMP1 CYP2C18 MUC5AC ALDH1A3 MUC6 COL1A2 P4HA3 THBS1 ALDH3A1 COL4A2 COL10A1 PMC8992553__F2 Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications DIABLO FADD BAX PMC7418797__F1 Therapeutic mechanism related to natural products HEL-S-28 SMAD2 APC SMAD4 HRAS PMC4276934__F2 Reactome mapping of differentially-expressed genes PML IRF7 IRF8 IRF9 IRF3 SP100 IFNG IRF6 PTPN21 MT2A IFI30 JAK1 IFNGR1 IRF-1 IRF4 IRF2 PMC4410070__F1 Accelerated Vascular Disease in Systemic Lupus Erythematosus: Role of Macrophage VCAM1 PMC7770493__F3 cAMP signalosomes at the endoplasmic reticulum, nucleus, and centrosome PLN PDE4D PDE3B AKAP8 PDE4A AKAP6 AKAP9 AKAP7 PMC7770493__F2 Mitochondrial cAMP signalosomes BAD MTX2 PDE4A SRC CHCHD3 RAB32 PBR STAR PMC7770493__F1 Plasma membrane and primary cilium cAMP signalosomes INA PCM1 GPR161 AKAP9 AKAP5 CFTR NHERF1 PMC8379492__F9 Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies TG FOXO1 HMGCR PMC9179518__F1 Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function VEGFC NOX4 CD36 PMC8021790__F2 Regulatory network model for alanine, aspartic acid and glutamate metabolism pathway(enzyme, posttranslational modification, activate, inhibition, catalysis, reaction, and combine PLCG1 HEL-S-62p PDE4D GAD2 AP2A1 GNB5 RAPGEF5 PI3 PDE6C F2 ATF4 SRC CD55 PLA2G4E DLG2 PRKG1 NRG1 SNAP25 HRAS PRKACG GAD1 PLCB1 GNA11 VAMP2 PDE4B ASNS GNAI3 GNAS RAF1 SOS1 SHC1 STX8 EPHB2 PMC7198709__F1 Biosynthetic pathways of NAD+ in mammalian cells includes de novo, Preiss–Handler, and salvage pathways, and the salvage pathway is the main source of NAD+ NAPRT NAMPT NRK PMC8815517__F1 mTOR Signaling in Kidney Diseases TSC2 TSC1 GSK3B PTEN DEPTOR RHEB MLST8 PMC4156761__F8 Schematic model shows the downstream signaling pathway of PIP5K1A and the effect of ISA-2011B inhibition PTEN CDC2 PIP5K1A SKP2 PMC4065255__F1 Core components of the insulin-like signaling pathway in C SGK1 PMC11525629__F3 MAOs in the suppression of antitumor immunity IL13 PTCH1 SHH IL4 PMC5866357__F3 General overview of metabolic pathways in healthy ECs CPT1A F2 SORD ASL FASN HEL-S-162eP GLS PMC4038158__F3 Signaling pathway initiated by Edn1-induced Ednra signaling NOTCH2 PLCB3 GNA13 HAND1 PLCB4 GNA11 EDN1 DLX6 EDNRA GSC GREM2 EPHA2 MEF2C HAND2 PMC11525629__F1 Signaling pathways activated by mito-DAMPs NLRP3 CGAS TLR9 IRF7 IRF3 MYD88 AIM2 MAVS PMC6923371__F3 Schematic illustration of a causal network in the Ingenuity Pathway Analysis (IPA) environment MMP7 HGF VEGFA PMC9477818__F1 Antimicrobial potential of a ponericin-like peptide isolated from Bombyx mori L. hemolymph in response to Pseudomonas aeruginosa infection DDC FADD PMC6468149__F1 The Hippo signaling pathway-YAP/TAZ in human endothelial cells ANKRD1 MOB2 AMOT AMOTL2 AREG LATS1 THBS1 MOB1A AXL PMC8987999__F2 Emerging diabetes therapies: Bringing back the Beta-cells HEL57 IGF1R IGF1 GSK3B IRS1 GLP1R PMC8165279__F1 Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses CS PDK2 PDK4 IDH3B HEL-S-32 MDH2 HEL-S-5 GOT2 PC FH PDK3 MPC1 MPC2 SUCLA2 OGDH COXFA4L2 HEL-S-133P HEL-S-281 PMC3995556__F9 BTC-stimulated IL-8 production and bio-behaviors of lung cancer cells BTC EGFR GRB2 MTOR PMC12103044__F4 Triggers and pathogenesis for pathological scar formation CYLD IRAK1 SMAD2 SMURF2 SMAD4 ARHA MYD88 HIF1A TAB3 PMC5288206__F6 Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas WNK1 CCND1 SLC12A1 PMC6787567__F3 Involvement and regulation of lncRNAs in M1‐like macrophage polarization HNRNPAB SET HNRNPL TRAF6 IL6 MYD88 IL5 COX2 IL18 IL7 TLR4 IL3 IL2 JAK1 IL4 SIRT1 PMC6787567__F2 Involvement of lncRNAs in monocyte/macrophage development and M1/M2 switch MARCO ACVR1B IFNG PMC9207355__F7 CEMIP promotes extracellular matrix‐detached prostate cancer cell survival by inhibiting ferroptosis CEMIP KEAP1 SLC7A11 PMC6923546__F5 Schematic representation of the proposed model: blocking PRMT5 promotes lung cancer cell death via Akt/GSK3B signaling pathway induced by resveratrol GSK3B PMC3380376__F3 Relationship between binding of ligands to the pattern recognition AGE receptor (RAGE) and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro- and microvasculature HMGB1 EGR1 NCL ARC PMC6533683__F1 mTOR signaling pathway regulated autophagy and EMT HEL-S-28 SMAD2 GSK3B RAC1 MTOR DKFZp686F0183 PMC10511167__F7 MiR-143/145 cluster induced by TGFB1 suppresses Wilms’ tumor 1 expression in cultured human podocytes SMAD2 SMAD4 WT1 PMC6533683__F3 P53 signaling pathway regulated autophagy and EMT ULK1 ZEB2 PTEN ATG10 MTOR PMC6533683__F2 Beclin-1 signaling pathway regulated autophagy and EMT WNT1 PMC6533683__F5 Integrin signaling pathway regulated autophagy and EMT HEL-S-28 EGFR MTOR PMC6533683__F6 WNTs signaling pathway regulated autophagy and EMT TWIST1 PMC6533683__F8 TGFB signaling pathway regulated autophagy and EMT PDE4A SMAD2 DKFZp686F0183 STAT3 PMC7290055__F4 Co-ordinately up-regulated genes of NF-Kappa B signalling pathway in HIV-H IL10 EDAR LTA TRADD ATM CYLD BASH BIK LTB LAT TIRAP PMC6858495__F3 pRB/E2F pathway dysregulation leading to unrestricted CASP3 gene transcription CASP3 CDK4 CDK6 PMC6769035__F1 Tumor microenvironment shapes NK cell metabolism and effector functions FBP1 MTOR PMC6858495__F7 Activation of PC-3 by PAC-1 and its derivatives via chelation of labile inhibitory zinc BRAF PMC5927694__F1 A conserved parallel pathway for telomere protection ATM ATRIP ATR PMC7439780__F6 Protein-protein interaction (PPI) regulatory network of proteins involved in the pentose phosphate pathway (PPP) DERA HEL-S-304 HEL-S-87p HEL107 RPE PMC8036323__F5 Cooperation of autophagy with phagocytosis in microglial activation COX2 ULK1 DKFZp686F0183 CD36 PMC3089810__F2 Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy BTK BIK LYN GRB2 SRC PMC9011276__F2 Narrative review of the role of the Notch signaling pathway in rheumatoid arthritis NOTCH2 NOTCH4 DLL4 NOTCH1 DLL3 NOTCH3 PMC6389150__F5 Model of NDV V protein regulating apoptosis in DF-1 cells HEL-S-114 BCL2 BAX PMC9334657__F2 Connecting Metabolic Rewiring With Phenotype Switching in Melanoma SCD ACSL3 CD36 PMC5347713__F7 Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway TLR4 CCND1 TRAF6 MYD88 TIRAP PMC11206024__F3 TLR4 signaling pathway TBK1 TRAF3 TRAF6 IRF3 MYD88 TIRAP PMC8781800__F3 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 NF1 SMAD2 SMAD4 PMC12014465__F2 TGFB1 signaling pathway plays multiple roles in amelogenesis ENAM AMELX KLK4 MMP20 AMBN AMTN PMC7050993__F5 Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion NOD1 CCL20 MTOR FOXP3 PMC8781800__F2 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 NF1 GRB2 MTOR PMC12014465__F1 TGFB classical signaling pathway SAMD3 TGFBR1 TGFBR2 SMAD4 PMC4931992__F7 Model of regulatory loop between Shh, IRS1, YAP, and YB1 IGF2 SHH IRS1 PMC8227424__F1 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer REL RHD PMC8677621__F8 Possible mechanism by which MCPIP1 regulates the EMT process and the Beta-catenin level ZNRF3 SFRP4 SNAI1 KREMEN1 SNAI2 CSNK1A1 CXXC4 PMC7539814__F6 Schematic diagram for blockade of autophagy in stable MED12-mut UtSM clone MED12 MTOR PMC7019488__F4 Steamed bread and baked bread on the cytokine network (a) and central metabolic pathway metabolic network (b) EGF IFNA2 HEL-S-162eP PMC8606765__F1 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells APC CD40 CD80 IFNG FOXP3 PMC9213282__F1 Influence of endophytes on rice fitness under environmental stresses MYB SOS2 ERF PMC8606765__F3 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells CD37 CD40 MYD88 CD8A CD19 PMC8606765__F2 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells TLR5 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR3 TLR7 TLR4 TIRAP PMC6320226__F1 Schematic diagram summarizing the regulatory role of the Id1/IGF2/VEGF/VEGFR pathway in esophageal squamous cell carcinoma (ESCC) progression CXCL5 IGF2 ID1 PMC5086583__F1 Immune effector cells induce tumor cell death through apoptosis and necrotic-like cell lysis RIPK1 RIPK3 FADD MLKL PMC6348814__F2 ALDH1A1 regulation, potential retinoid signaling pathways, and functional effects of ALDH in CSCs SIRT2 DLL4 SMAD2 SMAD4 HEL-S-53e PMC12115913__F4 The molecular mechanisms involving the interaction between the SARS-CoV-2 S protein and NRP1, DPP4, and CD147 cellular receptors DPP4 NRP1 MMP9 ACE2 PMC12115913__F2 The molecular mechanisms triggered by the interplay between SARS-CoV-2 S protein, ACE2, and integrin B1 receptors ACE2 IL1B TF ADAM17 PMC6628717__F3 ErbB-2 Downstream Targets to Promote PCa Tumorigenicity GRB2 PTEN PMC12115913__F1 SARS-CoV-2 infection pathways, spike protein domains, and main receptors TLR4 NRP1 FURIN ACE2 AXL ADAM17 TMPRSS2 PMC6686160__F8 Diagrammatic sketch of the working hypothesis FOXM1 SMAD2 PMC7589635__F1 Genetic pathomechanisms of FSHD types 1 and 2 SMCHD1 DNMT3B DUX4 PMC9111035__F4 Critical evaluation of risk to reward ratio of quercetin supplementation for COVID‐19 and associated comorbid conditions UCP1 ABCA1 TG PMC8722265__F8 SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression IL10 TLR4 IL4 ARG1 TRAF2 PMC8719534__F5 Human Metabolites of Hamaforton™ (Hamamelis virginiana L. Extract) Modulates Fibroblast Extracellular Matrix Components in Response to UV-A Irradiation SPARC ITGA1 ITGB3 MMP9 MMP11 CD44 NCAM1 LAMA3 PS1TP5BP1 LAMA1 TNC MMP14 MMP2 opn THBS1 ITGAV PMC3269678__F2 Signaling pathways leading to transcription factors activation in response to UV-radiation MAF KEAP1 ATF2 RELA EIF2A PMC7260202__F5 Crosstalk between androgen and Wnt/Beta-catenin leads to changes of wool density in FGF5-knockout sheep LEF1 SHH DKK1 PMC5510573__F2 Overview of the human androgen biosynthesis pathways STS CYB PMC3366852__F5 Proposed mechanistic link between Por deletion and up-regulation of MHC II expression in enterocytes SQLE STAT1 MHC2TA PMVK MVD FDPS MVK IDI1 HMGCS1 CD74 HMGCR PMC11292615__F0 This review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis NOTCH2 NLRP3 TLR4 MYD88 MTOR PMC3556575__F5 Pathways of relationships identified by feeding gene expression patterns identified in erythroid progenitors to the Ingenuity software PTGER2 MYOF PNRC1 HIPK2 CHAF1A CENPF TFDP2 MAP2K3 CDC34 TFDP1 ZMIZ1 ORC2 WDFY3 CBFB PDGFD HEL-S-94n UROS TEX2 CPOX ERMN HAGH FABP5 KIF15 CHI3L1 RBL1 FLI1 SKIL HBD VEGFA ENG MCM7 COCH WWTR1 GATA2 ZNF124 MCM5 MAX CDC6 TRAF5 SMURF2 ABCG1 hCG_2014051 TNFAIP2 DYRK2 IKZF2 MXI1 HHEX PMC8076952__F8 Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway PTCH1 GLI3 SMO TRPM7 BAX PMC11529329__F3 RPs and proliferation of HCC USF1 RPS27A CDK5 CCND1 CDK4 RPS15A RPL34 RPL8 PMC11529329__F2 RPs interacting with p53 and MDM2 RPLP2 RPL11 TLR4 RPL28 MDM2 RPL23 RPL26 RPL5 PMC3223033__F6 Schematic illustration of the main metabolic pathways based on the proteins identified in the citrus pulp chromoplasts F10 F2 F9 PMC11529329__F4 RPs and metastasis of HCC MMP9 FGFR3 RPL23 FGF18 RPLP1 RPS6 RPS16 RPS15A USP1 PMC8401288__F1 Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs PPCS PPCDC COASY HEL-S-5 PMC6759579__F5 Functional overview of the embryonic complement system HEL-S-62p CD59 C4B_2 CD46 C1QBP FH HEL-S-99n CD55 CR2 C1S CR1 CLU PMC9405713__F9 HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis CCND1 CDK4 PMC3336771__F1 Endogenous polyamines potentiate macrophage polarization TLR4 ARG1 PMC10670368__F2 SHP2 is critical in regulating RAS/ERK, PI3K/Akt, and JAK/STAT signaling pathways in cancer cells CSK GRB2 SRC MTOR PMC7139883__F12 Sphingosine kinase 1/S1P signaling contributes to pulmonary fibrosis by activating Hippo/YAP pathway and mtROS YAP1 SPHK1 SPNS2 PMC9356176__F12 The cystathionine Beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome CS PSPH ACLY HEL-S-162eP PMC4748291__F5 Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with tonsil colonisation by Streptococcus pyogenes TLR4 MYD88 PMC5569910__F1 The aryl hydrocarbon receptor (AHR) signaling pathway (A) is best known for the induction of xenobiotic metabolizing genes via activation by environmental toxicants AIP AHR PMC6343613__F1 Mechanism of IL-22, IL-22receptor as well as IL-22BP and signaling pathway STAT1 TYK2 JAK1 STAT3 PMC3222852__F1 GSK3 plays pivotal roles in the establishment and maintenance of neuronal polarization TSC2 KIF13B TSC1 APC PTEN MTOR RHEB PMC434255__F13 Current model for IL-7R regulation of survival and proliferation IL7 BCL2 JAK3 JAK1 BAX PMC5575761__F2 Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway GRB2 PTEN MTOR GRAP LAT BATF PMC3222852__F2 GSK3 is a key regulator of axon growth and branching APC GC PTEN PMC2676714__F4 Pathways analysis on the set of genes contained in the SNP component MAPK3 MAPK1 TNF ABCB1 HEL-S-32 APOE PMC5209629__F8 Inflammatory players implicated in lipopolysaccharide- (LPS-) induced M1 polarization of N9 microglial cells and of exosome upregulated microRNAs NLRP3 HMGB1 TLR4 CX3CR1 ARG1 IL1B PMC8125037__F2 PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma PBRM1 PTEN HIF1A MTOR TSC2 INO80 NFRKB TSC1 MC1R GNAS SETD2 STAT3 BAP1 PMC5454924__F1 Schematic presentation of ROS scavenging pathway in chloroplasts PC PRX PMC6200938__F6 Rag-independent Gln stimulation of mTORC1 via PLD-derived PA SLC7A5 PC RALA SLC3A2 ARF1 RHEB PMC5292650__F1 Human myeloid cells identified in the bone marrow, blood, and tissue of cancer patients CD14 CD33 CD163 CD68 PMC3087899__F6 NFKB pathway activation via death receptor signaling TRADD TRAF1 TNF TRAF2 FADD PMC11892029__F3 RNA methylation, DNA methylation, and demethylation in PH YTHDF2 MAGED1 MYADM ELK3 FOXM1 PTEN ALKBH5 WTAP DNMT3B IGF2BP2 YTHDC1 YTHDF1 BMPR2 METTL3 KLF4 KLF2 CYP1A1 PMC3997115__F1 Caspase activation by the extrinsic (Fas-mediated) apoptosis pathway (left) vs NLRP3 FADD PMC8073493__F2 Non-Coding RNAs in the Neuroprotective Effects of Glutathione PI3 BDNF PMC11892029__F2 BMPR2 and CAV‐1 in PAH BMPR2 GMPR2 CCNB1 IL15RA ARHA RAC1 PAH NOTCH3 NFYA TAGLN PMC8007978__F2 Metabolism of macrophages is beneficial to host defense or pathogen survival of during Mtb infection PDC F2 ARG1 ASS1 HK2 PMC2843003__F3 Epicardial-Myocardial Signaling Directing Coronary Vasculogenesis FGFR1 WNT9B SHH SMO GATA4 PMC5033243__F2 Emerging role of mTOR in the response to cancer therapeutics KIT EGFR ERBB3 APC TBC1D7 PTEN RHEB INSR TSC2 NF1 TSC1 ERBB2 AXL PMC6913967__F3 Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation FOS LCK PTEN LAT PMC11515775__F2 Caffeine metabolism pathway and metabolites AHR NAT2 ABCG2 POR CYP2A6 CYP1A2 PMC4822253__F1 BMP pathway TGFBR1 ID1 SMAD1 ID3 DKFZp781O1323 PMC6813227__F6 Signaling pathways SIRT2 IGF1R SMAD2 TGFBR1 SMAD4 MTOR EIF4EBP1 PDPK1 RPTOR RHEB TSC2 RPS6KB1 TSC1 IGF1 SIRT1 PMC5260886__F8 The serglycin–CD44 signaling pathway in NPC MYC CD44 CCND1 PMC5522110__F3 Subset of microRNAs defining the side population of a human malignant mesothelioma cell line EGF BAD BTC NRG2 SHE HBEGF MTOR NRG4 TGFA CRK JUN CBL PMC7842751__F9 Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway EGR1 RAPGEF2 PMC3565104__F4 Proposed model for progesterone and retinoid action in endometrium and endometriosis CYP26A1 CRABP2 HSD17B2 PMC11515775__F4 Genetic variants and their effects on caffeine dependence AHR MLXIPL HECTD4 ABCG2 POR CYP2A6 DRD2 BDNF CYP1A2 ALDH2 PMC3652335__F2 Lin28: Primal Regulator of Growth and Metabolism in Stem Cells LIN28B HMGA2 TCF3 SOX2 IGF2 TUT4 MYC LIN28A TUT7 HMGA1 PMC307558__F1 TGFB signaling pathway CDK2 SMAD4 ARHA PMC3814821__F8 Proposed mechanism for the CD8+-cell-mediated suppression of HIV-1 replication RNASEL RNASE1 CD27 CCR7 IFNAR2 IFNAR1 PMC4259288__F4 A.Genes with altered expression upon miR-224 stimulation are involved in the cell cycle control MAX ATM CDK2 GSK3B SMAD4 NRG1 SIN3A ATR PMC4090148__F11 Evidence that RASSF1C Stimulation of Lung Cancer Cell Proliferation Depends on IGFBP-5 and PIWIL1 Expression Levels ATM PIWIL1 IGFBP5 PMC6205166__F4 Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats POR MAP3K7IP1 JUN STAT3 TAB3 PMC7277968__F7 Reverse cholesterol transport pathway and intravascular remodeling of lipoprotein particles during the postprandial phase LPL ABCA1 TG PMC6205166__F9 Cachexia-inducing ability of 85As2 cells TLR5 IRAK1 LIF PMC8955777__F8 Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial–Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells TSC2 EGF TSC1 ERBB2 FOS JUN PMC5709760__F9 TGF‐B1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up‐regulation of IL‐17RB SMAD2 SMAD4 IL17RB PMC4133502__F1 Step forward back to (induced) fetal ATM JUN PMC9340150__F2 Structure, biosynthesis, and biological roles of fetuin-A: A review NOX4 IFNG PMC3298733__F1 New therapies targeting the deregulated pathways to treat TICs in pancreatic cancer CD44 NOTCH1 CD24 PMC8952793__F8 Global MicroRNA Expression Profiling of Buffalo (Bubalus bubalis) Embryos at Different Developmental Stages Produced by Somatic Cell Nuclear Transfer and In-Vitro Fertilization Using RNA Sequencing BAMBI INVS APC SOST CER1 SKP1 ARHA RYK PMC4026697__F3 VKR signaling pathways GRB2 SHB MTOR PMC10311107__F7 Metabolic and transcriptomic analyses elucidate a novel insight into the network for biosynthesis of carbohydrate and secondary metabolites in the stems of a medicinal orchid Dendrobium nobile DDC PAH PMC9479684__F4 When does hepatitis B virus meet long-stranded noncoding RNAs? HOXA13 CREB1 MTOR HAT1 NR1C1 PCNA PMC9479684__F3 When does hepatitis B virus meet long-stranded noncoding RNAs? FOS BST2 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IRF2 IL10RB PMC9479684__F6 When does hepatitis B virus meet long-stranded noncoding RNAs? APOBEC3B ROCK1 IRF3 STAT3 PMC9479684__F5 When does hepatitis B virus meet long-stranded noncoding RNAs? TLR9 RELA CD160 HDAC11 DDX5 MEX3B IFNG STAT3 PMC9031068__F2 Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action GSK3B SRC RAF1 PMC9479684__F2 When does hepatitis B virus meet long-stranded noncoding RNAs? RNASEL TLR8 CGAS TLR7 TLR9 MYD88 NOD2 TLR3 MAVS PMC12035894__F2 Carcinogenic mechanisms of estrogen and its metabolites in breast cells EGFR VEGFA MAPK1 PMC3976256__F9 Mycobacterium bovis BCG Triggered MyD88 Induces miR-124 Feedback Negatively Regulates Immune Response in Alveolar Epithelial Cells TLR7 TLR4 TLR9 TRAF6 MYD88 TLR1 TLR3 TIRAP PMC4911278__F5 Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression TSC2 ALDOB HK3 TSC1 PKLR HEL-S-304 DLD PTEN PDK4 PCK2 RHEB PMC5352068__F14 PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide TSC2 ULK1 ATM EIF2A MTOR STAT3 PMC9040349__F14 Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms KLHL13 RBM38 MSI1 SLC22A17 DGKD CNKSR1 EHD2 NNMT CHMP4C SH2B2 INPP4B CRMP1 PROKR1 PREX2 EPN3 ANGPT4 PREX1 SYNM TRIM72 LINGO1 GFRA2 GFRA4 ELMO1 PMC11033467__F5 Immunomodulatory effects of a probiotic combination treatment to improve the survival of Pacific oyster (Crassostrea gigas) larvae against infection by Vibrio coralliilyticus BIRC2 TLR4 PSMD10 BIRC3 RIOK3 MYD88 CAD BIRC7 TNFAIP3 TLR3 PMC3130144__F6 Molecular mechanism of autophagy with synthesis of cathepsin D TLR7 TLR9 UVRAG ATG14 TLR3 PMC3877165__F2 Schematic view of integration of TCR signal transduction with diverse components of the actin polymerization machinery ITK APC LCK VAV1 ZAP70 FMNL1 CDC42 PMC8623138__F1 Microalgae Xanthophylls: From Biosynthesis Pathway and Production Techniques to Encapsulation Development CS IPP PMC7495093__F7 Pyroptosis of acute kidney injury (AKI) signaling and protective effect of SalB through the nuclear factor erythroid-2 related factor 2 (Nrf2)/NLR family pyrin domain-containing 3 (NLRP3) pathway NLRP3 TXNIP GSDMD PMC5482648__F8 High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin PTBP1 SRC PMC3957180__F1 Scheme depicting interactions of the ET and NO pathway as described in this chapter NOS2 PMC9491642__F1 Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma AHR IL13RA1 TYK2 JAK3 PMC8990771__F3 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer EGF EGFR MTOR STAT3 BAX PMC8263655__F3 Long noncoding RNAs on tumor immune escape by regulating immune cells differentiation and function VEGFC CCR2 CCL2 PMC5408751__F7 GSK-3B modulation of LKB1-AMPK pathway in autophagy induction ULK1 GSK3B MTOR PMC8990771__F2 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer EGF EGFR GRB2 MTOR TGFA STAT3 PMC7021580__F3 MED12 and Cancer Drug Resistance MED12 EGF CARM1 SMAD2 EGFR TGFBR1 SMAD4 CDH2 MED23 PMC11012648__F3 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways ZNRF3 RNF43 APC PORCN PMC11012648__F1 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways SOX2 EPCAM ALDH1A3 CXCR4 CD44 HEL-S-53e SMO CD55 ALDH3A1 ALDH2 PMC3868999__F1 The Hippo pathway signaling cascade results in the phosphorylation and cytoplasmic retention of effector molecules YAP and TAZ LATS1 LATS2 PMC5487850__F1 Biogenesis of microRNA (miRNA), extracellular vesicles (EV) and uptake mechanisms AGO2 NPM1 NRP1 DROSHA PMC9088184__F6 PGK1-coupled HSP90 stabilizes GSK3B expression to regulate the stemness of breast cancer stem cells GSK3B HEL-S-68p PMC7438542__F1 Co-stimulatory signals that enhance MAIT cell activation IL7R IL23R ICOS STAT3 PMC5380038__F2 DHS and PHS metabolic pathways SGPP1 SMPD2 ALDH3A2 SPHK2 ASAH2 SMPD4 UGCG ACER1 CERS3 SGPL1 ACER3 LASS1 SMPD1 CERS5 SPHK1 DEGS1 CERS2 CERS6 SGPP2 PMC11993959__F2 Signalling pathways that regulate osteoblastogenesis RUNX2 PTCH1 SMO PMC6022935__F1 Streptomyces lividans major secretory route (Sec pathway) HTRA1 HTRA2 PMC2821476__F3 TNFA induced signaling TRADD TRAF2 FADD ITCH PMC3241928__F8 Beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas ME1 PIN1 BRAF PTEN PMC5380038__F6 PHS metabolic pathway ALDH3A2 SGPL1 SPHK2 PMC5380038__F5 Predicted PHS degradation pathway SGPP1 UGCG ALDH3A2 CERS3 SGPL1 LASS1 CERS5 SPHK2 CERS2 CERS6 SGPP2 PMC6214130__F2 Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function CYP27A1 ABCG1 ABCA1 NR1C1 CYP7A1 CD36 PMC9003256__F8 Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop MFN1 MFN2 NHS TFAM BAX PMC8234904__F2 Evidence-Based Chemotherapy for Oral Cancer: Focus on Drug Resistance Related to the Epithelial-Mesenchymal Transition SMAD2 SMAD4 PTEN PMC9030030__F3 Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets BAD JAK1 FLT3 MTOR PMC8228802__F2 ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development ATM CDK2 ATF2 TLK1 CDC2 RAD9A H2AX BRCA1 BAX PMC8882844__F2 Mitochondrial DNA Depletion Syndrome and Its Associated Cardiac Disease SUCLG1 SUCLG2 PMC8395197__F8 Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis TH PLIN1 CIDEC HEL-S-104 PMC6061130__F3 Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process MFN1 PINK1 MFN2 BCL2L13 FUNDC1 BNIP3L PMC9300530__F3 Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli MN1 PGC GAL CIT MAL PMC5146200__F1 Priming and activation of the NLRP3 inflammasome NLRP3 HMGB1 TLR4 PMC6620619__F4 Platelets involvement in the pathogenesis of AAVs VCAM1 VWF CD40 PMC1796761__F1 Pathway of double-stranded break repair by homologous recombination and the factors involved BRCA2 RAD52 PMC7643020__F3 Crosstalk between autophagy and apoptosis ATG3 TRADD DIABLO DKFZp686F0183 HTRA2 PMC5226613__F1 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases TSC2 MEI1 ATG12 RAC1 BNIP3 MTOR FGFR2 FGF7 PMC5226613__F3 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases TLR4 EGFR TRAF6 MYD88 MTOR PMC11202101__F1 Interleukin-17 signaling pathway (Kyoto Encyclopedia of Genes and Genomes (KEGG) ID: Human (Homo sapiens), hsa04657) TH TRADD MALL CXCL5 CCL20 APP CXCL8 CXCL2 TNF FADD S100A7 ELL PMC7533893__F6 NRF2 in regulation of cancer cell metabolism ME1 HEL-S-26 CDO1 UGDH CIT PHGDH MAL PMC10536424__F3 Anti-cancer mechanisms of PDE5 inhibitors CCND1 NOS2 MTOR ARG1 PMC9248441__F2 Understanding the Potential and Risk of Bacterial Siderophores in Cancer LCN2 DDIT3 BAX PMC6752947__F6 Tbx1-Isl1-Met genetic pathway regulates only a subset of CPM-derived muscles CPM PC HGF MYF5 TBX1 PAX7 MYOG ISL1 PMC7533893__F3 Mechanisms involved in the aberrant activation of KEAP1/NRF2 pathway in cancer CDK20 DPP3 PALB2 KEAP1 NFE2L2 GSK3B MICA PMC7533893__F2 Classical KEAP1/NRF2 signaling pathway ME1 HEL-S-26 GCLM KEAP1 GCLC GPX2 HMOX1 SRXN1 PMC10380440__F3 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis CANX AFP CUTA HEL-S-99n TNF IFNG TAPBP PMC10380440__F2 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis HRC CASQ2 TRDN RYR2 PMC9180643__F3 Monoubiquitination in Homeostasis and Cancer HDAC3 HLTF MDM2 SMAD4 PCNA PMC9651583__F4 Integrated text mining and PPI for the combined effects of Hst and VCR on cancer-related signaling pathways MAPK8 FOS PTGS2 VEGFA INS MYC PTEN IL6 TNF MTOR CASP3 CASP9 BCL2 JUN TGFB1 CASP8 PMC7430831__F6 NOD-like receptor signaling pathway and DEGs in NOD-like receptor signaling pathway from KEGG enrichment analysis of R TBK1 NOD1 IRF7 NLRX1 TRAF3 IRF3 NOD2 MAVS PMC6879841__F6 Pathway diagram of glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid (TCA) cycle highlighting metabolites that differed between control (CON) and intrauterine growth restriction (IUGR) fetal skeletal muscle and plasma HEL-S-30 BCAT1 PFKM HEL-S-133P PMC7698939__F1 Tryptophan metabolism through the kynurenine (yellow), serotonin (blue), and indole (purple) metabolic pathways ASMT KYNU KMO AANAT PMC2718504__F5 Predicted general metabolism and solute transport in T HEL-S-11 PGP MSC POR NAPA PMC12093341__F1 Biosynthetic pathway of CR and strategies used in this study ASPA HEL-S-20 PMC9113786__F1 Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities POMC LEPR STAT3 PMC9442958__F10 ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NFKB pathway by the secretome VEGFC IGF1 TNF PMC4644174__F8 Proposed signaling pathway for TOB-1-mediated progesterone signaling.Notes: TOB-1 was involved in the growth arrest pathway in response to progesterone in MCF-7 cells TOB1 HEL-S-44 PTEN PMC3561798__F6 Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis AHR CCL26 PTPN1 COA1 FLG JAK3 IVL JAK1 HRNR PMC6514922__F1 Hypothetical model for the role of thrombomodulin (TM) in mitogen-activated protein kinases (MAPKs) signaling: Thrombomodulin regulates the activation of MAPKs under various pathophysiological conditions FGFR1 PC APC S1PR1 ARHA RAC1 PMC4682714__F2 Provides a schematic and abbreviated overview of the TGFB signaling pathway with indication of aneurismal diseases linked to it SMAD2 SMAD4 PMC3875822__F1 Metabolic model of C4 assimilation, rates of reaction, and net fluxes between and GLA MAL PMC4263397__F9 Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra TH PITX3 NONO FGF10 HEL-S-53e BDNF RGS6 PMC8851748__F1 Viral and cellular oncoproteins inhibit the cGAS/STING pathway TBK1 CGAS IRF3 PMC7040094__F1 C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity CLEC12A CARD9 SAP130 BCL10 IL1B CLEC9A PMC12003952__F10 PLEVPs deliver pab-miR396a-5p to mediate down-regulation of the IL-17 signaling pathway CXCL5 CXCL10 IL6 STAT3 PMC9535337__F1 Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander? HEL-S-62p CD59 C9 VTN FH C7 C6 CR2 TNF FCN1 CR1 IFNG PMC11843235__F6 Working model for ADAM10 in lung cancer MMP9 NOTCH1 ADAM10 CDH2 PMC5400641__F8 MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1 MCL1 DIABLO PMC3092676__F4 Emerging molecular functions of RASSF8 CSK SRC PMC3075071__F1 Parsing out the complexity of RAF inhibitor resistance NRAS ARAF PMC5727283__F5 ER stress and the caspase proteolytic system are important regulators of muscle protein homeostasis ATG12 ATF4 EIF2A XBP1 DKFZp686F0183 PMC6994936__F8 Proposed involvement of FGF9/FGFR2 signalling in human fetal gonad development WNT4 FGFR2 SOX9 FGF9 SRY PMC8502912__F8 LPA1-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38A and JNK2 MAPK pathways in smooth muscle cells PKD1 LPA TF PMC9265296__F1 New Insights into Hippo/YAP Signaling in Fibrotic Diseases TEAD4 LATS1 PMC10520536__GA1 Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/Beta-catenin signaling pathway SMAD2 APC GSK3B NET1 COL1A1 PMC6810856__F10 Rhinovirus -induced SIRT-1 via TLR2 regulates subsequent type I and type III interferon responses in airway epithelial cells STAT1 STAT2 IRF9 IRF3 TLR1 SIRT1 PMC2915755__F1 PCNA-coupled p21 degradation after DNA damage: the exception that confirms the rule? ATR DDB1 PMC8194282__F2 Neuroinflammation in Post-traumatic Epilepsy TLR4 SMAD2 MYD88 PMC8965109__F9 Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma MED12 ROCK1 ARHGEF12 NBN SMAD4 TFDP2 GPAM SMC1A ACVR2B MED13L TOPBP1 APAF1 PTPN11 MSH6 RAD50 ZFYVE16 SP1 PRKDC RAD21 RBL1 ROCK2 ANAPC1 ZFYVE9 CDKN1B BRIP1 STAG1 STAG2 CBL CREBBP EP300 BMPR1A SMC3 CDK2 ACVR1B PIK3CA MED13 SOS1 LAMC1 DKFZp781O1323 RB1CC1 USP1 APPL1 PMC2970576__F5 Analysis of gene expression in CD44+/CD24− MCF-7/ADR cell population by TaqMan Low-Density Array and Ingenuity Pathway analysis NR3A2 MYC NBN BCL2L1 WT1 HSF1 CCNE1 CEBPD GBP1 TNFSF6 AHR MDM2 SRC CDK4 PRKDC JUN ANXA1 LBR BAK1 TP63 MMP9 ADRB2 TCF7L2 CEBPA TNF IKBKB HEL-S-102 GIG8 EP300 PELP1 MAX NFKB2 YY1 PMC4921268__F2 Searching for the Chokehold of NRAS Mutant Melanoma CCND1 CDK4 CDC2 MTOR CDK6 PMC4535548__F12 ERK/MAPK signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA BAD MOS NFATC1 GRB2 SRC DOCK1 EIF4E CRK PXN PMC7920285__F1 The differences in the localization of the upstream regulators and the core cascade components of the Hippo signaling pathway during murine and bovine embryogenesis AMOT YAP1 NF2 PMC4535548__F11 EIF2 signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and the pathways were analyzed using IPA ELF2 EIF2A PMC3549669__F6 STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway TBK1 DDX41 IRF3 IFI16 PMC2572856__F1 Aging of signal transduction pathways, and pathology NODAL APC SMO PTEN PMC5354754__F1 Novel non-canonical Wnt signature for prostate cancer aggressiveness FYN FZD2 JUN PMC4535548__F14 PI3K/AKT and HSP90 interacted with ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA TSC2 BAD TSC1 HEL-S-28 MDM2 PTEN EIF4E MCL1 MTOR RHEB PMC5406709__F1 PI3K pathway targeting agents in development for the treatment of prostate cancer TSC2 TSC1 PTEN PMC6631185__F4 Signaling pathway nodes effected by loss of CDK11 in A375 melanoma cells following PanCancer Reactome pathways analysis CCNA2 SFN CDKN2C MYC UBE2T PKMYT1 MAD2L2 POLE2 WEE1 CCNB1 MSH6 CCND1 MSH2 CCNE2 BRIP1 MDC1 MCM7 DDB2 CDC25B BRCA1 RFC3 RFC4 MCM5 MCM2 BRCA2 CDK2 FANCA FANCB PCNA FANCG PMC7925099__F1 HIV-1 life cycle, assembly pathway, and assembly plate screen CCR5 CXCR5 PMC4535548__F13 NFKB signaling pathway was regulated via ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA TBP LCK TRAF2 PMC2844640__F3 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy SMAD4 BAX PMC2904914__F2 Glial cell line-derived neurotrophic factor can signal through a Ras-induced pathway in SSCs RET CDK2 GRB2 ATF1 GDNF PMC3296744__F11 Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development PIAS1 TYK2 JAK1 PMC2904914__F1 Glial cell line-derived neurotrophic factor can signal through activation of Src kinases in SSCs RET LYN GDNF SRC PMC2844640__F1 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy SMAD2 TGFBR1 SMAD4 PMC7917554__F3 Pyroptosis NLRP3 IL1B CASP5 CASP4 PMC3546685__F1 Short-patch (SP-) and long-patch base excision repair (LP-BER) sub-pathways FEN1 NEIL2 NEIL3 PCNA NEIL1 PMC7917554__F4 Key features of different forms of regulated cell death GPX4 PARP1 PMC11015457__F9 Compound-target-pathway network TH IGF1R DKFZp781B1423 EGFR MAPK14 MTOR THRA PRKCA KDR FGF3 MDM2 SRC IL2 CDC2 NR1A2 JUN KIT PTGS2 FGF2 MMP9 VEGFA PARP1 TNF NR1C1 CASP3 PTPRC MAP2K1 GRB2 PIK3CA BCL2 RAF1 PPARG SIRT1 TERT STAT3 PMC2665757__F6 EXT/HSPG pathway involved in both peripheral and central chondrosarcomas IHH EXT2 EXT1 PMC8616344__F7 Identification of Gene Co-Expression Networks Associated with Consensus Molecular Subtype-1 of Colorectal Cancer BAD FOS POLK APC MYC GRB2 CASP9 SMAD4 BAX PMC8569219__F6 Studying the tumor microenvironment and engineering of tumor organoids NF1 GREM1 BRAF APC GC SMAD4 PIK3CA ARHA PTEN CDKN2A TF BAP1 PMC8474014__F8 Transcriptomic and Metabolomic Analyses Provide Insights Into an Aberrant Tissue of Tea Plant (Camellia sinensis) FH INS C13orf34 PMC7699519__F1 The NRF2 pathway ME1 PTGR1 GCLM KEAP1 SQSTM1 SLC7A11 GCLC GSTM1 SKP1 RBX1 HEL-S-128m HMOX1 TXN BACH1 HEL-S-22 GSTM2 HEL-S-26 MAF GPX2 GSTM4 GSTA3 TXNIP GSTM3 PMC12045473__F3 Chloride channel regulation in human diseases E2F7 CIC MTOR IRS1 CFTR PMC10474666__F4 FBXW7 in breast cancer: mechanism of action and therapeutic potential WEE1 RELA TNF MTOR FBXW7 PMC3702632__F7 TLR4 and chemokine receptor crosstalk CCR2 TLR4 ADRBK1 PMC7195637__F5 Regulation of mTOR on Th17 cell differentiation RORC SOCS3 GFI1 HIF1A MTOR DEPTOR STAT3 PMC7195637__F7 Regulation of mTOR on Th9 cell differentiation HIF1A DEPTOR IRF4 FOXO1 PMC7195637__F6 Regulation of mTOR on Treg cell differentiation DEPTOR FOXO1 FOXP3 PMC8217358__F1 Gene- and RNAi-Activated Scaffolds for Bone Tissue Engineering: Current Progress and Future Directions MOG RUNX2 DLX5 MAP3K7IP1 SMAD1 DKFZp781O1323 PMC8408623__F2 Medical gas plasma-stimulated wound healing: Evidence and mechanisms KEAP1 NONO HEL-75 RBX1 NQO1 PMC7195637__F1 mTOR signaling pathway and its functions TSC2 TSC1 PC TFEB DEPTOR PMC3260518__F1 Invisible hand: regulation of RHO GTPases by RHOGDIs ICMT RCE1 RHO SMURF1 CDC42 PMC3066060__F2 Simplified schematic representation of the apoptosis pathway in mammals and Drosophila DIABLO FADD BAX PMC7277693__F6 Upregulated genes (red boxes) related to ER-stress and leading to apoptosis and protein degradation EIF2S1 HEL-S-125m OS9 ERO1B DNAJB11 ATF4 EIF2A BCL2 EIF2AK1 TRAF2 XBP1 DDIT3 PMC7277693__F5 Schematic view of genes downregulated (green) and upregulated (red) in the biosynthesis and degradation pathway of cholesterol CH25H DHCR7 FDFT1 DHCR24 MVK IDI1 HMGCS1 MSMO1 HMGCR PMC10571764__F1 Therapeutic mechanisms involving elotuzumab and Anti-SLAMF3 in multiple myeloma (MM) CSK GRB2 SLAMF7 TF PMC6049001__F4 In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway IRF7 IRF3 MAVS PMC8672419__F4 FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease BTK SHE TEC PMC8718643__F3 Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium TSC2 GSK3B TBC1D4 PMC6029133__F6 Cancer-related pathway-pathway relationships CXCR3 PLK1 FOXM1 SMAD2 ATF2 CXCR4 IL8RB RB1 IL4 ATR PMC3702532__F8 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation LALBA CANT1 HEL-S-19 NME2 PMC3702532__F7 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation PRKCZ MAPK9 PRKAR1A MAPK3 GSK3B TRIB3 PYGB TRIP10 PDPK1 EXOC7 ACACB PCK2 MAP3K1 SOS2 FOS SH2B2 HRAS CRK FOXO1 RHEB CALM1 TSC2 HEL-S-80p TSC1 RPS6KB2 IGFBP1 GRB2 IGFBP2 IGF2R BAD INS MTOR RPTOR INSR PTPN1 RPS6 ARAF JUN FASN PDE3B INPPL1 FBP1 MAP2K2 GYS1 PTPRF FLOT2 IKBKB LIPE HEL-S-42 PTPRE SHC1 PIK3R2 PMC3977809__F2 EGAN analysis showing all the differentially expressed enriched pathway genes EPO SKA2 CRLF1 RFT1 PRTN3 POMC KRT37 SEMG1 CEP192 CNTFR MFAP1 PHLDA3 GPD2 COL2A1 FOXE1 TPSAB1 LMAN1 OFD1 CENPA CXCL11 SST LACRT RPP14 PTPN13 GAST BCAN CCKBR IGSF21 VCAM1 MSLN CBLC TERT TBCE CSF3 BLM SFTPD TEAD4 WRN IPO11 GABRB3 ALG10 CCL27 CEP290 KRT14 ALG11 GDF6 SDC1 FGF2 FGFR3 ZNF443 KERA XPO4 SGMS1 SMC3 SMC2 SMC6 CEP70 USP47 FANCM FANCE PMC5337695__F2 EGR1 regulations and functions in the central nervous system in the context of synaptic plasticity SNAP91 EGR1 STX6 NAB1 GRIN1 CHRNA7 ARC SNAP29 GAD1 PMC4886063__F7 P2-dependent activation of the IRK/PI3K/Akt pathway IGF1 GSK3B PMC3974825__F1 Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer ATM RAD51 ATR PMC7532256__F2 Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside VEGFA IL6 AQP4 CD19 PMC3940258__F5 Paramyxovirus inhibition of IFN signaling pathways STAT1 STAT2 TYK2 JAK1 PMC1716201__F1 Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 BAD BIK BCL2 MCL1 BMF HRK BAX PMC8669959__F7 Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review TLR9 VEGFA PTEN BAX PMC7694131__F1 Canonical and non-canonical Wnt signaling pathways RUNX2 APC GSK3B LRP5 LRP6 ARHA ROR2 PMC9160188__F3 Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment NLRP3 GSDMD PMC7373899__F2 Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction SOCS3 IRF2 SOCS1 USP18 PMC8214274__F2 Histone dynamics during DNA replication stress RIF1 FANCD2 BLM POLK BMI1 RNF2 MCM7 POLN MRE11A AQR MCM3 MCM5 MCM6 MCM2 BRCA2 SETX ATRIP RAD51 ATR DNA2 PMC5686050__F1 Interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor complexes PI3 IL13RA2 IL13RA1 JAK3 PMC7596939__F3 MiRNA regulation in signaling processes in obesity, liver and uterine cancers MAP3K1 BAD GNB2 HSP90AB1 FLNA FLT4 IFNAR2 PPP2R1B ITGB1 NFATC3 GNG12 CCND2 DKFZp686L0365 LAMB1 NFKB2 SYK JUN ARAF PHLPP1 AKT3 PMC7407311__F7 CXCL14 regulates hESC self-renewal and cell cycle through IGF-1R signaling pathway IGF1R SOX2 CDC2 CXCL14 CDK6 PMC4358129__F11 MiR-199a-5p in smooth muscle differentiation and hypertrophy ACTA2 MYOCD KLF4 CCND1 AXIN2 ID3 PMC7660801__F5 Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement HEL-S-62p CD59 C9 CS C4B_2 C6 MASP2 MBL2 C4A CR1 PMC3343154__F3 Mammalian unfolded protein response (UPR) pathways ATF4 EIF2A TRAF2 XBP1 PMC8469536__F2 From the Evasion of Degradation to Ubiquitin-Dependent Protein Stabilization EIF2A RNF4 PMC7037239__F1 IL-15 signaling pathways GAB2 GRB2 JAK3 JAK1 MTOR STAT3 PMC4722981__F1 The mechanism of TRPC5 in mediating chemoresistance TRPC5 NFATC3 PMC4627418__F5 Cytokine receptor interaction network for GBM survival EPOR CCR2 EGF TNFRSF14 EPO EGFR CCL21 TNFSF13 IL12A TNFRSF11A PPBP CCR1 CSF1R NGFR GHR IL17A IL2 KITLG LEPR CSF2 IL1B IL1A IL13 LTB IL8RB TNF PRL LEP LTA CXCR4 TNFRSF10B TNFRSF10A CSF1 LTBR PMC12069117__F21 TREM2 signalling pathways LCP2 SOS2 LAT2 VAV1 GRB2 SRC SYK ADAM10 LAT CBL PMC3164671__F5 Genome-Wide Identification of Bcl11b Gene Targets Reveals Role in Brain-Derived Neurotrophic Factor Signaling NGF MAPK10 GRB2 ATF3 BDNF PMC10451232__F4 Transcriptomic changes in p53-associated apoptotic signaling in burn-wound-healing pathway HGF HAL BAK1 CCL4 TNF CASP3 IGF1 APAF1 NFKB1 PMAIP1 MDM2 CASP9 BCL2 JUN CASP8 BAX BOK PMC8684614__F4 Epigenetic modification and BRAF gene mutation in thyroid carcinoma BRAF CCND1 PTEN PMC2593440__F3 Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells NDN CCNH GABPB1 CDK6 RYBP E2F2 APP CDK4 COL2A1 RBL2 RBL1 ETV3 PFAS MAD2L1 GTF2H4 IGFBP7 PARP1 TOB2 PPP1CC E2F7 GIG8 DHFR PARP2 PPP1R2 CAMKK2 PMC10299161__F4 Oxidative stress promotes the activation of programmed cell death initiated by intrinsic apoptotic signaling in the mitochondria or extrinsic apoptotic signaling by death receptor pathways in CRC cells BAD BAX PMC6165336__F11 AAP-H and the PI3K/AKT/mTOR signaling pathway BAD MTOR BAX PMC5290952__F10 Proposed mechanism whereby RET/PTC3 regulates IDO1 expression in thyroid cancer cells STAT1 IDO1 RET SRC IRF-1 PMC7937358__F3 Immuno-pathogenicity of MERS-CoV DPP4 ATF2 IRF3 PMC6951458__F1 Mnk 1/2 signaling EIF4E SPRY2 PMC9523788__F2 Innate and adaptive immune evasion by dengue virus STAT1 IRF9 TYK2 JAK1 IFNAR1 PMC12073561__F5 Small RNAs are involved in the regulation of plant female gametophyte development PIN1 AGO4 ARF6 ARF3 PMC12224056__F3 Schematic representations of the effects of iron chelation on CRC pathogenesis and progression ATM ROCK1 APC MDM2 ATR PMC5478005__F1 Wnt/Beta-catenin signaling pathway APC GSK3B TEF LRP5 LRP6 PMC12224056__F4 TRAIL‐mediated apoptosis pathway FADD BAX PMC6060673__F1 Immunomodulatory approaches for the treatment and prevention of neonatal sepsis TH CD14 TLR4 CXCL8 IL6 IL1B PMC4106090__F1 N-glycosylation pathway MNT GANAB GCS1 MANEA PMC4143615__F2 Top-ranked enriched canonical pathway identified using IPA, the T-cell receptor signaling pathway ITK FYN CSK LCK ZAP70 GRB2 TEC CRAT SHB LAT CBL PMC4106090__F3 GPI anchorage pathway PIGF PIGO PIGW PIGH PIGM PIGN ERI1 PIGL PMC2972271__F5 The metabolite NAD+ oscillates in a circadian manner NAMPT SIRT1 PMC4222698__F2 Clinical utility of pharmacogenomics in the management of hepatitis C STAT1 SOCS3 STAT2 SI MAVS PMC4222698__F1 Clinical utility of pharmacogenomics in the management of hepatitis C KY SOCS3 STAT2 IRF7 IRF9 RIGI IRF3 TYK2 IFNAR2 IFNL4 JAK1 MAVS PMC2860309__F1 EDA signaling EDARADD EDAR LEF1 RELA LTB SHH TRAF6 FURIN DKK1 TNLG7C DKK4 MADCAM1 PMC6768854__F7 MiR-708 expression gradient is reduced during the transformation from normal prostate epithelial cells through adenocarcinoma cells to NEPC SESN3 CDC2 EZH2 FOXO1 TCF4 PMC11497390__F7 Rosmarinic acid promotes cartilage regeneration through Sox9 induction via NFKB pathway inhibition in mouse osteoarthritis progression MMP3 COX2 ACAN COL2A1 IL1B SOX9 PMC5264327__F8 Working model representing the proposed signaling pathways induced by vitamin D signaling in regulating skeletal muscle mass NR1i1 FOXO3A EBP IL6 BNIP3 RPS6 IL6R STAT3 PMC3477504__F3 Cytokinesis Mechanics and Mechanosensing INCENP KIF12 IQGAP1 PMC3579404__F1 Conserved Wnt pathway branches and components LEF1 TCF3 HIPK2 APC LRP5 LRP6 RYK ROR2 RHO CDC42 PMC8026309__F6 The mechanism through which CTRE inhibits MGO-induced tubular cell inflammation and oxidative stress by upregulating the Nrf2-antioxidant enzyme pathway and downregulating the PKCB/NOX4 signaling GLO1 IL16 GCLC NOX4 TNF NQO1 PMC7946919__F8 Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas FRS2 GRB2 FGFR2 PMC10039784__F1 Deficient radiation transcription response in COVID-19 patients MYC PIGS PTEN RFWD2 TSC2 CASP3 SIAH1 AIFM2 PERP ATM CDK2 MDM2 CASP9 C6 BCL2 ATR SIVA1 CASP8 BAX PMC3252833__F3 Sensitisation of type 2 cancer cells towards DR-induced killing by synthetic IAP antagonists CASP3 PMC6051204__F1 Folate‐mediated one‐carbon metabolism, links to methylation reactions and nucleotide synthesis (by Cheng TY et al HEL-S-61p GGH MTR SHMT1 DHFR MTRR TCN2 MTHFD1 HEL-S-51e MTHFD2 SLC19A1 PMC3252833__F1 Fas-induced apoptotic signalling pathway CASP3 CASP9 BCL2 BAX PMC6854237__F3 Microbiota-triggered EMT via E-cadherin/Beta-catenin APC GSK3B CCND1 PMC3900498__F1 Yin and Yang of PI3K vs PTEN in the regulation of beta cell proliferation TSC2 TSC1 PTEN MTOR RHEB PMC5449449__F2 Integration of metabolic and fatty acids (FAs) metabolizing enzymes pathway in mitochondrial dysregulation, fibrotic hypertrophy, and chronic inflammation IRS1 FOXO1 PMC7248192__F2 Hyperglycemia-induced oxidative stress impairs nitric oxide signaling NLRP3 IL16 VCAM1 TXNIP HEL-S-162eP PMC11008464__F1 New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis ME1 NAT8L SIRT5 OTC CIT ARG1 NAGS ASS1 ASL MAL HEL-S-5 GLS PMC5098220__F3 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks PIK3CD PIK3R1 IL3RA SOCS2 PRKCZ SOCS3 HEL-S-1 IRAK1 TRAF6 TEC IRAK4 MYD88 CRKL STAT1 FYN IL7R MAPK1 HEL114 NMI PPP6C IL1A VAV1 IL1RN MAP3K7 FES CRK IRS1 RXRA CXCR4 IL2RG GRB2 PPP2CA BCL2 MAP3K14 SHB IL2RA TERT PLCG1 IKBKG CHUK BAD IL1R2 IL1R1 YES1 CSF2RB BCL2L11 MTOR CEBPB RARA PTPN11 IL2 NCOA1 PTPN6 ETS2 IL1B JUN NR3C1 PILRB RAC1 CBL NLK SIRPA NFKBIA RPS6KB1 EP300 GAB2 MAP3K2 NFKB1 RELA LYN CD40 JAK3 SYK JAK1 RAF1 SOS1 HEL-S-93 SHC1 PXN PIK3R2 STAT3 PMC5555610__F2 RAS Proteins and Their Regulators in Human Disease PIK3CD BRAF RASA2 NRAS SYNGAP1 RASA3 RGL3 KSR1 MAPK1 ETS2 RAPGEF2 ARAF JUN RAPGEF1 FOS RRAS RRAS2 CBL KSR2 MAPK13 MAP2K1 RASGRP3 RPS6KA1 DUSP16 DAB2IP PIK3CA RAF1 SOS1 RASAL1 RASAL3 RPS6KA2 RGL2 RASGRP4 PMC5098220__F2 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks PIK3R1 ATF2 EGFR PAK6 CCNH CREB1 RB1 CCND3 RANBP9 CDK7 SRY CCNE1 PIAS2 MDM2 SRC SP1 JUN RUNX1 NR3C1 SPDEF CDC25B HDAC1 BRCA1 FOXO1 GTF2H2 PRMT1 RAC3 CREBBP PIAS1 NR2C2 IL6ST ETV5 ERCC2 RAN PXN PIK3R2 PMC4084718__F4 Contextualizing Sharpin within the NFKB pathway by comparative analysis of mutant transcriptomes NFKBIA IL1A IL18 IL16 RBCK1 SHARPIN TRAF6 MYD88 TNF PMC11396780__F9 Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism of Protopanaxadiol Triphenylphosphate Derivative in Non-Small-Cell Lung Cancer SIRT6 EGFR FGFR3 MTOR YARS MARS1 SLC16A3 PGAM1 HEL-S-133P SIRT3 PMC5355171__F2 Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? BAD GSK3B PTEN CDC42 BAX PMC5098220__F1 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks PIK3R1 DOK5 GRIP1 NCK2 CREB1 TRAF6 RANBP9 NCK1 GABRB3 FYN NGFR FRS2 PTPN11 NTRK2 SORT1 RAC1 SH2B2 GRIA2 TIAM1 SIRPA GRB2 PPP2CA DOCK3 FRS3 CRTC1 BDNF PIK3R2 PMC2528242__F1 Peroxisome proliferator-activated receptorG and ligands: pathways and functions FOS SP1 TNF JUN STAT3 CD36 PMC3998676__F1 ADVANCING AGE IS ASSOCIATED WITH GENE EXPRESSION CHANGES RESEMBLING mTOR INHIBITION: EVIDENCE FROM TWO HUMAN POPULATIONS TSC2 ULK1 TSC1 IRF7 PTEN IRS1 SGK1 RHEB STAT3 PMC5648159__F6 Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells YAP1 FFAR3 FFAR2 LATS1 PMC7589994__F1 Role of the best-characterized HDACs in liver fibrosis BAMBI TLR4 SMAD2 SMAD4 HDAC2 EZH2 TGFB1 HDAC1 SIRT1 PMC4376617__F7 The role of T cells in the anabolic activity of iPTH in trabecular bone LRP5 LRP6 CD40 PTH WNT10B PMC9647849__F4 Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways SNCA ABO MCU SPN GAL BAX PMC5338674__F7 Model for Pol E function in plant DDR WEE1 ATM PARP2 RAD51 ATR BRCA1 PMC5129950__F1 miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1 MAX SUV39H1 ATM CDK2 MDM2 SMAD4 NRG1 BMI1 SIN3A ATR PAK1IP1 PMC7028499__F7 21-BENZYLIDENE DIGOXIN DECREASES PROLIFERATION BY INHIBITING THE EGFR/ERK SIGNALING PATHWAY AND INDUCES APOPTOSIS IN HELA CELLS CASP3 EGFR CASP9 BAX PMC6071020__F5 Neurotrophin signaling pathway and genes involved in the significant gene links (marked in red box) BAD SI FRS2 SHE TRAF6 RHO RAC1 BDNF CRK BAX PMC6349306__F1 Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway SGK1 PMC8741964__F1 Impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites HEL-S-90n KYNU KMO PMC4111852__F3 PI3K pathway in different breast cancer subtypes TLR4 PTEN PMC5428929__F6 Genome-wide transcriptome profiling of radish (Raphanus sativus L.) in response to vernalization PRR9 ELF3 PRR3 PMC7373816__F2 Metabolic regulation of the Hippo-YAP signaling network CGAS AMOT OGT IGF2 ARHA IRF3 LATS1 MTOR JCAD LATS2 PMC7373816__F1 Hippo-YAP signaling network NLK AMOT SRC LATS1 HEL-S-31 CDK7 PMC8655512__F2 Progranulin as a Potential Therapeutic Target in Immune-Mediated Diseases PRTN3 FOXO4 TLR9 JUNB COMP STAT3 PMC3485747__F1 Glutamine:fructose-6-phosphate amidotransferase 1 (GFPT1)–mediated MTOR signaling pathway affected by glucose and fructose in porcine trophectoderm cells TSC2 RPS6 EIF4EBP1 MTOR GFPT1 PMC7429631__F2 Profilin can be phosphorylated at S137 by Rho associated kinase (ROCK) downstream of vascular endothelial growth factor (VEGF) signalling, reducing actin polymerisation rates SRC RHO PMC7429631__F1 Profilin interactions in the membrane EGF PTEN MTOR PMC7300907__F10 Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection TBK1 STAT2 IRF9 IRF3 IFNAR2 IFNAR1 TLR3 STAT1 TYK2 JAK1 ACE2 MAVS STAT3 PMC8323830__F2 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy BRCA2 RAD52 RAD51 DNA2 BRCA1 PMC3187694__F1 Simplified model of autophagy ATG12 MTOR PMC4707157__F1 Mechanisms by which mitochondrial DNA activates innate immunity TLR9 IRF3 IL1B PMC3291562__F4 Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells PIK3R1 MAPK9 SOCS3 MAP3K11 CAP1 MAPK8 MAPK3 GSK3B MAPK14 HEL-S-61 PPP1R3A FLOT1 MAPK1 PRKCI MAP3K1 PRKCQ SOS2 MAPK7 MAPK10 MAP3K7 RRAD MAP2K5 MAP3K5 IRS1 SNAP23 RHEB TSC2 SHC2 GYS2 TSC1 VAMP2 MAPK13 RPS6KB2 MAP3K14 MAPK11 PRKCH CBLC MAP2K3 XBP1 MAP4K3 INPP4A INPPL1 GRB14 MAP3K6 STXBP3 EHD1 STXBP1 EHD2 KIF3A RAB4A MAP3K10 MAP3K13 RAC1 MAP3K12 SNAP25 TBC1D4 ARF1 PIK3C2G PTPRF PIK3R4 CBL IKBKB MAP4K2 MINK1 LIPE SGK2 MAPK6 SLC2A4 MAPK4 MAP3K2 HEL-S-42 SHC1 PIK3CD PRKCZ TRIB3 PRKAA1 MAP2K6 PDPK1 PRKCA MAPK12 FOS EIF4E HRAS PIK3R3 CRK HEL-S-31 GRB2 ENPP1 MAP2K4 MYO1C INS PTEN PFKM EIF4EBP1 SHC3 MAP4K1 INSR PTPN1 PTPN11 JUN IRS4 EGR1 PRKAA2 GSK3A MAP2K2 GYS1 PFKL RPS6KB1 MAP2K1 PIK3CA MAP3K8 RAF1 GRB10 SOS1 ARF6 SOCS1 PIK3R2 PMC8323830__F1 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy ATM BRCA2 ATRIP RAD51 ATR BRCA1 PMC7115894__F4 Effect of elevated Na+ on cancer progression and the tumour microenvironment SIK3 RAC1 IL4 GLS PMC8277109__F2 Nutrient signaling pathways altered by methionine restriction (MR) ELF2 FGF21 HEL-S-182mP IGF1 UCP1 ATF4 PMC9331286__F1 T Helper 22 Cells in Dermatological Disorders STAT1 AHR CCR6 CCR10 CCR4 TYK2 JAK1 MTOR IL1B STAT3 PMC5683188__F1 Localization of key lipids and enzymes, designated by the genes encoding them, in different cellular compartments in S CDS1 PC PSD2 PMC3983226__F1 Predicting Kinase Activity in Angiotensin Receptor Phosphoproteomes Based on Sequence-Motifs and Interactions BAD PMC9035589__F9 Microbial Utilization of Next-Generation Feedstocks for the Biomanufacturing of Value-Added Chemicals and Food Ingredients PDC CS NADK PMC9105930__F1 Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart GPX4 GSK3B PTEN IL1B MLKL BAX PMC3632731__F2 Network 2 (metabolic disease, renal and urologic disease, and molecular transport) generated by pathway analysis of the hot list CD99 FPR1 LAMB2 HEL-S-87p ADCYAP1R1 MCAM PTPRN HEL-S-269 opn LTBP2 TEF APP GRIA4 RYR3 PMC3632731__F1 Network 1 (antigen presentation, cell-mediated immune response, and humoral immune response) generated by pathway analysis of the hot list COL18A1 C4B_2 PLG AFM VASN C4A A2M CLSTN3 APP ENO2 C6 LPP ATR PMC8669501__F1 SNAIL1: Linking Tumor Metastasis to Immune Evasion SUFU SMAD2 APC SHH SMAD4 MTOR PMC11840414__F1 Steroidal glycoalkaloids biosynthetic pathway in potato (Solanum tuberosum) and tomato (Solanum lycopersicum) GCA PGA3 PMC10986082__F2 Multiple mechanisms of environmental stress regulating CSC transcription A The immune cells in TME activate the STAT, Wnt, AKT and Notch pathway of CSC by mainly releasing cytokines (IL-6) and inducing contact POSTN CD44 MTOR TF PMC8836862__F10 Blood Bacteria-Free DNA in Septic Mice Enhances LPS-Induced Inflammation in Mice through Macrophage Response TLR4 TLR9 TRAF6 IRF3 MYD88 PMC10986082__F1 Targeting TFs in CSC from multiple perspectives A Directly blocking the combination of TFs and DNA: mainly through epigenetic mechanisms CD44 SMO TF PMC6304621__F3 General representation of the signaling pathways involved in CBD anticancer mediated effects GPR55 TRPV2 TRPV1 PMC6215866__F3 Transforming growth factor‐beta pathway and the Wnt/Beta‐catenin pathway SMAD2 LRP5 LRP6 PMC6215866__F2 Positive feedback loop between the Rspo/Lgr5 pathway and the Wnt/B‐catenin pathway RNF43 LRP5 LRP6 GPR49 PMC6215866__F1 Mouse breast carcinogenesis induced by the activation of the canonical Wnt pathway GSK3B MYC LRP5 LRP6 PMC5854685__F8 Pathway from hippocampal molecular defects to AD neurotoxicity HEL-S-128m PRDX3 CPLX2 PMC6328535__F6 Dacarbazine and PLX4032 cross-resistance emerges via distinct MAPK-dependent and -independent pathway activation BRAF PDGFRA NRAS MTOR PMC5215656__F6 Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways EGR1 PAK1 NGF CDK5 FOSB CAD PMC11085123__F1 Biosynthetic pathway of terpenoids (A), alkaloids (B), and phenylpropanoids (C) in plants MVK IPP MVP PMC7598160__F3 Glycolysis and oxidative phosphorylation in the retina VLDLR CPT2 FFAR1 HEL-S-5 PMC6471220__F3 Transcriptional effects in zebrafish liver after feeding with 25% of maize substitution CTH BCKDK SLC16A10 MAT1A SLC38A4 ACACA GDA INS PAH APOE PMC3628745__F2 New signaling network for melanoma KIT BRAF CHP2 EGFR APC NRAS FGFR3 FGFR2 PTPRF CXCL13 TNC WNT4 SRC KITLG SHC4 PMC8230717__F3 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study BAD EPO HEL-S-11 BOK PMC9386448__F2 Phytochemical and pharmacological profile of taraxasterol NLRP3 COX2 TLR4 IL6 MYD88 MTOR IL1B GSDMD BAX PMC8230717__F2 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study NLK CDK2 CYC1 INS PMC6062380__F4 Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD) †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00166a FAHD2A RBP1 GDA ALB SGTA PAH TTPA FDPS HEL-S-299 SERPINA1 KNG1 DDT PON2 EEF2 EHD3 PON1 HEL-S-47e GATA2 HEL-S-69p HEL-S-162eP HEL-S-22 HEL-S-61p HP HEL-S-269 HEL-S-20 FABP1 PMC2927527__F2 “Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress ATF4 EIF2A XBP1 PMC3416961__F1 Simplified diagram depicting Ras signaling and crosstalk with PI3 kinase- Akt pathway in leukemia BCR FLT3 MTOR PMC3274818__F1 Activation of an RTK induces dimerization and downstream phosphorylation of non-receptor tyrosine kinases NF1 GAB2 EGFR RHO PTEN CDC42 PMC9274112__F3 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy TLR4 TRAF6 MYD88 PMC9274112__F2 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy TRAF6 IL1R1 MYD88 GSDMD PMC9274112__F1 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy TLR4 SMAD2 TRAF6 IRF3 MYD88 PMC3394505__F9 Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas APC PTCH1 PMC8919059__F6 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma EREG TUBA3E HLA-G IL1A TRIM71 IGF2 PHOX2B CDKN2A ALOX15B LEP MAPK4 CTCFL INHA FAM9C TDRD12 PMC8919059__F5 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma ELAVL3 SFTPD ALB STMN2 NEFH SCGB1A1 SPRR2E AMBP PAH SPRR2F SPRR2G NPY SPRR2A GC CRP SPP2 FOXG1 SERPINA10 KRT5 GAL SLC5A2 NTRK2 ALDOB ChAT TAGLN3 HRG CALCA NTS CASP14 SNAP25 FOXD1 SPRR2D SFTPB CCKBR CPB2 LEP SH3GL2 SYNPR SFTPA1 PLA2G2A CHRNB2 PMC4350422__F1 Immunologic manifestations of autophagy TBK1 ULK1 IL16 TLR7 TLR9 IRF3 MAVS PMC2947220__F8 Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer CDK2 PMC9622808__F6 Schematic model CYP27A1 CYP7B1 PMC545795__F3 Largest connected subgraph resulting from combined query on four pathways involved in carbohydrate metabolism: glycolysis/gluconeogenesis (red); pyruvate metabolism (yellow); TCA cycle (green); and the glyoxylate cycle (pink) PGM2 PIR ENO2 CIT ACD GAD1 HEL-S-68p PMC6829426__F13 A potato plant’s response to weak light and exogenous Ca2+ CIT PMC4276148__F1 Regulation of miRNAs in NHL MYC CCND1 PXDN PTEN SIRT1 PMC4896088__F1 Nodes of therapeutic blockade in the PI3K and other signaling pathways that synergize with BET inhibition MYC MDM2 PTEN INPP4B IRS1 PMC3033967__F8 Structural Characterization of the Polar Lipids of Clostridium novyi NT. Further Evidence for a Novel Anaerobic Biosynthetic Pathway to Plasmalogens PGP C1S PSD PMC2983087__F2 Mechanisms of double-strand break repair in somatic mammalian cells PALB2 BRCA2 BARD1 RAD51 BRCA1 PMC3134378__F3 Regulation of HIF-1A by the PI3K pathway TSC2 PML TSC1 PTEN CA9 MTOR PMC5673087__F3 Diagrammatic representation of hypothesized molecular mechanism of LH signaling dysfunction in PCOS women modified from NF1 HMGA2 RAB5B TOX3 YAP1 CYP11A1 GATA6 FSHR KIAA1608 CYP17A1 INSR PMC7450969__F4 Ribosomal/TRP53 pathway pattern mediated by Salmonella infection SDCBP PSEN1 F2 TNFRSF8 CDK4 PTEN RPL9 RB1 PCNA RPL39 PMC11672923__F8 Signaling pathways involved in adipocyte metabolic disorders caused by melatonin decline with aging and HFD in eWAT NLRP3 GPX3 MMP9 CEBPB PMC8773898__F2 MicroRNAs and Long Non-Coding RNAs in Sarcopenia MYF5 MEF2C IGFBP5 IRS1 MYOG PMC3134378__F2 Regulation of HIF-1A by the MAPK pathway BRAF CA9 RAC1 PMC5699945__F5 Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins GSTM2 ACOT7 HEL-S-67p GSTM1 ALDH3A1 HMOX1 PHGDH HEL-S-22 GLS PMC4500461__F2 Genome-Wide Identification of Differentially Expressed Genes Associated with the High Yielding of Oleoresin in Secondary Xylem of Masson Pine (Pinus massoniana Lamb) by Transcriptomic Analysis PMVK MVD MVK IPP PMC7429854__F8 Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy EGFR HBEGF NRG1 AQP4 PMC8920547__F4 Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia C9 C7 C5AR2 C6 SLAMF7 PMC3376391__F2 Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease KEAP1 PRX PMC6536719__F5 EGL-9 inhibits the HIF-1 target NHR-57 from reducing RAS/MAPK signaling through a DELTA/NOTCH-induced negative feedback loop EGF EGLN3 EGFR PMC11011857__F3 Genetic Signature of Human Pancreatic Cancer and Personalized Targeting EGF EGFR MTOR PMC6120701__F3 Interleukin (IL)-2 signaling pathway GRB2 IL2RA JAK3 RAF1 JAK1 TF IL2RB PMC10031116__F6 Extracellular matrix stiffness—The central cue for skin fibrosis SMAD2 SMAD6 SMAD4 TRAF6 ARHA TGFBR3 TRAF4 CDC42 PMC3723562__F7 Polyethyleneimine Mediated DNA Transfection in Schistosome Parasites and Regulation of the WNT Signaling Pathway by a Dominant-Negative SmMef2 WNT1 PMC8776636__F1 Ovarian Biomechanics: From Health to Disease KIT FOXO3A GC PTEN CTGF PMC10031116__F5 Extracellular matrix stiffness—The central cue for skin fibrosis SPSB1 HEL-S-28 TGFBR1 TGFBR2 LATS1 RHO MTOR PARVA LATS2 GRB2 SRC UNK TGFBR3 TRAF4 PMC5883129__F1 Ubiquitin cascade TRAF6 TRIM62 PELI1 PMC4927085__F8 Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer ATM EGFR PMC11794838__F9 HU protecting against DKD in this study VCAM1 IL6 BAX PMC4418220__F9 Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth CS LTB CXCL2 PMC8802208__F1 DSB repair pathway choice BRCA2 RAD52 RAD51 PARP1 XRCC3 WRN PNKP BRCA1 PMC8602044__F4 Plasma triacylglycerols are biomarkers of Beta-cell function in mice and humans HSD17B12 ST3GAL3 UQCRB ABHD6 COX7A2 NDUFV3 NDUFA5 PLA2G12A NR1i1 NEU3 NDUFA13 NDUFA9 HSD3B2 TTC7B COX6B1 COX7B CERK HSD17B11 NDUFS5 COX7C ATP5PB NDUFB5 GPD1 NDUFS6 NDUFV2 NDUFB9 NDUFAB1 COXFA4 UQCRC2 AGPAT5 HEL-S-49 NDUFB4 PIP4P2 UQCRH AGPAT4 NDUFA3 NDUFB3 PITPNC1 NDUFA10 ST3GAL1 DEGS2 PMC5332470__F1 T cell differentiation and the emergence of CMV-induced T cell phenotypes CD27 CCR7 PMC4509649__F3 Trade-Off between Growth and Carbohydrate Accumulation in Nutrient-Limited Arthrospira sp. PCC 8005 Studied by Integrating Transcriptomic and Proteomic Approaches MAP2 MAEL APC RPE PMC11913853__F12 Differentially expressed genes implicated as top candidates for mediating the effect of selective breeding on behavior are often regulators of bioenergetic function LIPT2 SPG7 MCU WDR93 OGDH LSR UCP2 PMC5226821__F13 m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks IGF1R CTBP1 EGFR MYC TPM3 TGFBR2 PUF60 BCL2L1 SNRPA CRKL CDK6 RARA PRPF31 JUP CHERP PTPN11 MDM2 CCND1 MAPK1 ARAF PRPF4 BAX CDKN1B VEGFA HRAS SNRPC CRK CBL CREBBP SNRPE HNRPA3 LAMB1 TCERG1 CDKN1A MAX DDX42 NFKB1 RELA U2AF2 LSM4 RAF1 TRAF2 SHC1 FADD TGFB1 ARNT2 TRAF4 WBP11 PMC7823498__F1 Biological regulatory network (BRN) of IP3R with tumor suppressor and onco-proteins PML BAD PTEN MTOR BAX PMC9404922__F1 Expression of Key Factors of the Hippo Signaling Pathway in Yak (Bos grunniens) Mammary Gland LATS1 LATS2 PMC6664075__F6 Hypothetical scenarios for the role of NGF after systemic oxidative stress GCLM NGF KEAP1 PMC7435111__F1 Scheme of the heme biosynthesis pathway and membrane transporters FECH UROD UROS ABCG2 PPT1 PMC10304648__F1 Detection of influenza A virus infection by pattern recognition receptors (PRRs) and NLRP3 inflammasome NLRP3 TLR7 HP IRF7 RIGI IRF3 TLR3 MAVS PMC5820294__F1 Signaling pathways involved in the progression of extramammary Paget’s disease CXCR4 CCR4 CCL17 CDK4 CDH2 MTOR CDK6 PMC7530063__F8 Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes MBP UGT8 PRX PMC6805690__F6 Noise-induced bistability and resolution of fate dichotomies MDM2 NOTCH1 PTEN SIRT1 HES1 PMC11708511__F7 Inhibition of triple-negative breast cancer growth via delphinidin-mediated suppression of the JAK2/STAT3/PD-L1 pathway CD69 STAT3 PMC8868551__F8A Folic Acid Homeostasis and Its Pathways Related to Hepatic Oxidation in Adolescent Rats Exposed to Binge Drinking DHFR NOX4 CYP2E1 PMC3152951__F1 Interaction between HCV and Nuclear Receptor-mediated Pathways NR1C1 CYP7A1 CD36 PMC6805690__F4 Notch-induced autophagy and translational noise as destabilizers of cellular memory MCM6 MCM2 GSK3B MYC PTEN MTOR PMC6805690__F1 Notch pathway amplifies intrinsic noise by interactions that improve the efficiency of global protein synthesis GSK3B MYC MDM2 PTEN HIF1A HES1 PMC7241336__F1 De Novo and Salvage Biosynthesis of Pyrimidine Nucleotides for Host and Viral RNA SynthesisGSK983 is a DHODH inhibitor CDA UCK2 UMPS CAD DHODH CMPK1 PMC6912418__F2 Mechanism and signaling pathways involved in mitochondrial adaptation in heart following exercise CITED4 IGF1 PMC7073175__F10 The proposed mechanism underlying the TCEE-mediated anti-inflammatory effect in ECs and atherosclerosis VCAM1 APOE PMC4496299__F4 Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation EIF2S1 CD133 UCP1 RPE65 MYL1 TNNI3 PCSK9 NEU3 ACADS BMP5 RBP4 DDT APOE RBM38 ANGPTL4 LGI1 NEDD8 IRS1 NR1C1 KCNB1 ARID1A ACAT2 ACADL TNS1 MAP1A CP PHLPP1 PMC5994774__F5 Both mTOR and eIF4E phosphorylation are needed for polysomal recruitment of terminal oligopyrimidine messenger RNAs (TOP mRNA) TTI1 GRB2 PTEN EIF4E MTOR DEPTOR MLST8 PMC9313364__F7 Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma ANGPT2 CCL4 STAT3 PMC5994774__F2 Scheme of PI3K/Akt/mTOR pathway depicting both complexes mTOR protein takes part in, mTORC1 and mTORC2 TSC2 TTI1 TSC1 PTEN EIF4E MTOR DEPTOR RHEB PMC5883129__F2 Activation of NEMO and IKB by multiple signaling pathways RELA TRAF3 TRAF6 IRAK4 TRIM25 PMC3753467__F1 IP3 instigates the activation and amplification of NFATc1 NFATC1 GAB2 TRAF6 PLCG2 PMC9654807__F1 Prognostic and Therapeutic Potential of DNA Damage Repair Pathway Alterations and Homologous Recombination Deficiency in Lung Cancer PALB2 ATM BRCA2 XPC RAD51 PARP1 ATR BRCA1 PMC3886798__F3 Overview of the treatments in the context of previous results obtained with a test system based on the fluorescent reporter protein H 6-GFP-BD-CVIL in transgenic tobacco BY-2 cells FOS NRAS HRAS PMC5552450__F6 Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis PSAT1 PSPH PHGDH PMC7416122__F2 Network of actual biochemical pathways constructed for S CDS1 MAEL GPT2 ERG ENO1 CIT MAL PMC2953497__F10 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells EGR1 RPS14 POM121 JAG2 PCOLCE HMGCS1 FBXW11 SMURF1 RPS26 UBB REG3A BRCA1 KLK10 NFKBIA NFKB2 ASB2 SP4 NOTCH1 ATP2A2 RPS27 FBXL20 SMAD1 FOXS1 DKFZp781O1323 PMC9521401__F2 Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules GCLM CTSK SFN RUNX2 GCLC NFATC1 MSC OSCAR DCSTAMP SMAD1 NQO1 PMC4352427__F1 TRAIL-receptor mediated signalling pathways TRADD BCL2 TRAF2 BAX BOK PMC3843161__F3 Biomarker-guided translation of brain imaging into disease pathway models TNFRSF14 MBP NCF4 STK24 PRTN3 MMP7 USO1 TNFSF6 FYN KDR HEL103 DFFA SATB1 PICALM DCC BFAR FOS PSEN2 CNP ADRB2 RPL30 CASP10 LMNA PLCB1 NEDD4 TIAM1 EDAR NFKB2 PPP2CA HEL113 AKT3 CDC42 MUC1 MAP2K4 RUNX2 TFCP2 CHD3 BNIP2 RIPK1 IL18 NOD1 PLD2 IFT57 APP GNAZ TFAP2A MYO1F PRKDC RADIL ARHGDIB GRB14 CD34 ADD2 RRAS ARHA RAC1 GAP43 MAPKBP1 PS1TP5BP1 PTPRC RPAP3 NFKBIA SDC4 LYN PARP2 TP53AIP1 RAF1 GRB10 CRADD SMC4 PSENEN SHC1 BCAP31 STAT3 PMC10815595__F1 HBV-HCC pathways of top 10 downregulated miRNAs CHUK TGFBR1 MAPK3 MYC RB1 VDAC3 CDKN1A NFKB1 CDK2 GRB2 SRC BCL2 JUN PMC10815595__F2 HBV-HCC pathways of top 10 upregulated miRNA CASP3 SRC DDB1 PMC5479307__F4 There are similarities and significant differences in light and dopamine mediated phase regulation of the retinal clock in Xenopus leavis driving melatonin release and that in mice driving PER2∷luc expression DDR1 OPN5 OPN4 PER2 PMC7904891__F1 Susceptibility and protective factors of the lectin pathway of complement and complement receptors, for HBV infection per se and HBV infection/leprosy HEL-S-62p C4B_2 MASP1 FCN3 C4A CR1 PMC7188667__F4 Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression UGT2B17 UGT2B28 UGT2B15 PMC5686097__F2 Cellular metabolic pathways driving mononuclear phagocyte inflammatory vs HEL-S-62p RET ACLY IL1B HK2 PMC7744503__F7 Mycoplasma pneumoniae lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response NLRP3 TLR4 IL1B PMC8226122__F4 Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies HEL-S-62p PLG MASP2 PMC4643722__F3 Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases APP FADD PMC6843432__F4 Coordinated contribution of ROS and BMPs to vascular diseases CASP3 ALPL COX2 RUNX2 BMP2 TRAF6 NOX4 XDH PMC6278198__F5 Schematic summary of the possible mechanism for GLCCI1 in glucocorticoids pathway GCGR GC IL1B GLCCI1 PMC6284329__F3 Decorin in cancer, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (http://www.genome.jp/kegg‐bin/show_pathway?hsa05205) CASP3 TLR4 MMP2 CD63 TIMP3 MMP9 EGFR VEGFA TNF MTOR EIF4B PMC6843432__F1 BMP signaling pathways RELA TRAF6 MTOR PMC3753831__F2 ERK1/2-mediated regulation of the BCL2 protein family BAD BRAF FOXO3A BCL2 MCL1 BMF PMC3753831__F1 ERK1/2-mediated regulation of the G1-S phase transition BRAF MYC CCND1 JUN CCND2 PMC5977009__F1 Toll-like receptor signaling pathway TBK1 TLR8 TLR7 TLR4 IRF7 IRAK2 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TLR3 PMC6335330__F1 Epigenetic regulation at the RUNX3 AS-associated locus RUNX3 IL7R IRF4 PMC3368734__F7 Functional interaction network analysis of genes with enriched expression (EE) and differential splicing (DS) in the placenta GADD45G FOS CA9 CITED2 GATA2 NFATC2 EP300 JUNB SP1 CSF2 ADM SP3 GATA3 PMC9538505__F11 TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure ANXA1 MPO HEL-S-30 CALU SFN ALB ENO1 DDB1 CDC34 CLU HEL-S-162eP GDF15 HEL-S-269 SRPK1 KRT13 VCP ATP1B3 B2M TFAM MICOS10 APOE SDHB PMC6678087__F3 Representation of the two serrated pathways BRAF HP PMC7163052__F1 Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer EGR1 NGF GDNF PMC8456215__F1 Emerging Targets in Type 2 Diabetes and Diabetic Complications TSC2 TSC1 GSK3B PMC6287696__F1 The mechanism by which Rel/NFKB-dependent STING expression activates antiviral autophagy to restrict ZIKV infection in fly brain REL DKFZp686F0183 PMC5676072__F1 Sirtuin roles in Hedgehog, Wnt/B‐catenin, and Notch stem cell signaling pathways BCOR SIRT2 APC SIRT6 GSK3B SIRT1 DACT1 BCL6 PMC5891173__F3 Aldo‐Keto reductase 1C2 (AKR1C2) expression in prostate cancer cell lines HSD3B2 AKR1C2 CYP17A1 PMC8257776__F1 Molecular pathways of apoptosis and necroptosis TRADD CYLD FADD MLKL BAX PMC4143352__F7 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease CYBA LAPTM5 CTSS NRARP TM7SF2 HMOX1 OSMR RGS14 INPP5D CTSA B2M TPP1 LIN7B FXYD7 HEL70 IRF8 CD300C GFAP CNP HLA-B PDLIM2 HTR1A KCND2 ITGAX PLEK ABCA1 POU3F1 C4B_2 CX3CR1 CD83 CXCL13 ARL2BP C1QA NCKAP1L ARF3 JUN PLXDC2 CD68 GNS USF1 C3AR1 HEL-S-130P CTSZ TYROBP PTPRC HEL-S-171mP GIG8 C1QC ASS1 CCL3 STAT3 PMC11951496__F1 Double role of IL-6 in the pathogenesis of atherosclerosis NLRP3 TLR4 MYD88 PMC4264188__F2 BMP signaling pathway ID1 SMAD1 DKFZp781O1323 PMC4143352__F5 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease HEL-S-62p C9 C4B_2 C7 C6 ITGAX CR2 C1S C4A C3AR1 CR1 PMC6876322__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the target genes of CTD-2357A8.3 in HNSCC tissues TFAP2B ZNF329 PIM2 GSK3B LCOR MNT PTK2B MDM2 FMNL3 BTG2 WNT7B ZFP30 HEL70 PSD4 SLC39A1 ZNF394 NEK4 SAMD4B NONO ANP32E WIPF3 ACVR1B TERF1 MLL2 ACVRL1 PEAK1 WNT7A TPM3 LRP8 TFRC ZNF708 TNFRSF13C EPHB4 MLLT1 TEAD2 FOXC1 ZNF417 HEL-S-108 SESN3 E2F2 NGFR ANKRD23 SOCS7 LDLR XRCC3 AGAP1 SLC3A1 CCL11 HEL-S-47e TXNIP SCML2 REL SRP19 SASH3 STAT3 PMC1761701__F10 Proposed model of lacritin mitogenic signaling pathway lacritin signaling suggested by data outlined in the text LACRT SDC1 LPA MTOR STIM1 PMC8335813__F6 HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization HHLA2 MMP2 CDK2 CD163 MMP9 EGFR CDK4 CDH2 CDK6 PMC3787301__F4 The physiological and metabolic landscape of Melainabacteria AIP MALL CIT PMC7736543__F2 Reciprocal signaling between the capsule and cortex coordinately regulates SHH and Wnt pathway activation ZNRF3 RSPO3 WNT4 PTCH1 SHH SMO PMC7736543__F1 Adrenal cortex employs multiple cell populations with stem cell function to support cellular renewal SHH WT1 CYP11B2 PMC2736203__F2 Impact of a mixed microbial challenge on cell cycle control in HIGK ATM OXT ATR PCNA PMC3759014__F1 The main constituents of the Sonic Hedgehog (SHH) pathway include the SHH ligand and the transmembrane proteins PTCH1 and SMO PTCH1 SHH SMO PMC4832107__F2 Genome-wide gene expression analysis for S49 (Neo) and S49 (OS 4–25) cells CAD BAX PMC7115196__F6 Pathway network associated with PCOS LEP F2R opn RBP4 IL12B PMC11039994__F8 Levels of p53 govern the hierarchy of DNA damage tolerance pathway usage PCLO REV1 HLTF PRIMPOL POLL POLN PCNA ZRANB3 POLI PMC8621344__F2 Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration PAX7 REST PMC8141177__F1 LINC00261: a burgeoning long noncoding RNA related to cancer APC PMC3237867__F1 Metabolic pathways, transport, and receptors of S1P APOM RHO SPNS2 PMC11997273__F2 The vagus afferent nerve conveying gastric-derived ghrelin signals GHSR NTS ARC PMC2832309__F2 WWOX gene and gene product: tumor suppression through specific protein interactions ERBB4 HGF RUNX2 APC JUN WWOX PMC9598866__F5 Metabolite Profiling of Paraquat Tolerant Arabidopsis thaliana Radical-induced Cell Death1 (rcd1)—A Mediator of Antioxidant Defence Mechanisms GAL IPP GLS PMC4182081__F3 Regulation of TCF7 and HSP90AA1 by hsa-miR-185-5p in a prostate cancer pathway MDM2 BCL2 PTEN PMC4182081__F2 Regulation of YWHAG, YWHAB, and PCNA by hsa-miR-185-5p in a cell cycle pathway MALL SMAD2 ORC1L PMC2530034__F1 Transcriptional regulation and the pathway of RNA polymerase II transcription POLL CDK9 CDK7 POLI PMC2491640__F5 Regulatory network of important genes involved in EBV-dependent NPC CD9 HOXA9 FOS MMP9 EGFR EMP3 MEIS1 DEK GADD45A MAP3K5 PBX2 CDKN1A CDX2 KMO CDK2 PSPH IMPDH2 PTMA JAK3 JUNB SP1 HEL107 STAT3 PMC2600469__F4 Genes regulated by SHP in PPAR signaling pathway SCD LPL CP CD36 PMC4182081__F4 Regulation of TCF7 by hsa-miR-20b-5p and hsa-miR-17-5p in a thyroid cancer pathway RET BRAF MYC TPR PMC4349157__F1 Sphingolipid metabolic network GCLM OPLAH GCLC GPX1 SMPD1 LPA HEL-S-22 PMC3889683__F3 Schematic presentation of potential signaling network of HER2-NFKB-PI3 K-Akt-STAT3 MAP9 PTPN13 RB1 STAT3 PMC11280308__F3 Mechanisms of action of the A TRADD STAT2 IL13 SMAD2 SMAD4 CREB1 TNF MTOR STAT1 APAF1 CDK2 CDK4 CD80 CDC2 CDH2 IRF4 FADD STAT3 CDC42 BAX PMC6128084__F6 Cellular metabolism for heme synthesis during early and late erythropoiesis ALAS1 SLC25A22 SLC25A38 ALAS2 CP PMC6522942__F1 Cell surface and endosomal signaling pathway of TLRs TLR5 TLR9 IRF7 FOS TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 JUN PMC6678403__F3 Negative role of AMPK in angiogenesis SMAD4 MTOR SMAD1 DKFZp781O1323 HES1 PMC6522942__F3 Polyphenols modulating upstream (TLR activation) and downstream (different kinase and transcription factors) pathway of surface and endogenous TLR to reduce or demolish pro-inflammatory cytokines and type I interferon generation TRAF6 IRAK4 MYD88 TIRAP PMC6522942__F2 TLRs-signaling in microglial cells in different neurodegenerative disease progression TLR5 TLR7 TLR4 TLR9 MGAT3 MYD88 TLR1 IL1B PMC6678403__F1 Regulation of sprouting angiogenesis DLL4 HES1 PMC4898593__F5 Signal transduction from G-protein-coupled receptors and integrins ARHH SRC ARHA SYK PLCG2 DOCK2 CDC42 PMC1386711__F4 MAPK signaling pathway mapping FAR1 FUS CDC42 SELL OPA1 PMC6721652__F1 Canonical WNT pathway in on and off states APC LRP6 PMC9240865__F3 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease RET LPA MBOAT7 PMC6721652__F4 Drugs developed against canonical WNT pathway components APC SOST LRP6 PORCN TNKS DKK1 PMC9240865__F2 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease PC LPA MBOAT7 PMC6182840__F1 The sorting mechanism of exosomal miRNA MiRNA genes are transcribed into primary miRNAs (pri-miRNA) by Pol-II AGO2 DROSHA EXPH5 PMC6721652__F3 Canonical WNT pathway components associated with disease APC LRP6 PMC8393842__F1 Adding Some “Splice” to Stress Eating: Autophagy, ESCRT and Alternative Splicing Orchestrate the Cellular Stress Response TSG101 ULK1 CHMP2B CHMP4B ATG10 MTOR DKFZp686F0183 PMC4217539__F6 Human pre-BCR-induced signal transduction depicted from the current study PAX5 RAG1 ZAP70 PMC8983055__F3 Proteomic and Phosphoproteomic Changes of MAPK-Related Inflammatory Response in an Animal Model of Neuropathic Pain by Differential Target Multiplexed SCS and Low-Rate SCS HEL-S-62p HMGB1 CS AIFM1 NRG1 ORM1 CNTF TLR4 SORL1 A2M CFH CRP CNTFR AHSG LBP ILF3 HEL113 HMGB2 CHI3L1 APOE STAT3 PMC6716664__F3 MicroRNA regulation in colorectal cancer tissue and serum BAMBI NODAL PITX2 TGFBR1 ARHA TNF LTBP1 IFNG FST CREBBP ACVR2A TGFBR3 INHBA PMC6716664__F2 MicroRNA regulation in colorectal cancer tissue and serum BRAF INS PTEN INSR NLK CCK ATM MAFK CDK2 MDM2 KLF2 BNIP3 REL PMC9223523__F3 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa DEAF1 TRAF6 MYD88 TUB PMC3951797__F6 Postsqualene cholesterol biosynthetic pathway DHCR7 EBP SC5D DHCR24 PMC9223523__F5 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa CYLD ATF2 MYD88 TUB REL FADD PMC9223523__F4 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa RYBP CYLD TRAF6 CAD REL DPT FADD PMC3428657__F1 The signaling pathway ofGHRregulated by let-7b SOCS3 IGF1 GHR LEPR IRS1 PMC7643606__F2 Leishmania spp.-induced activation of the NLRP3 inflammasome NLRP3 SYK IL1B GSDMD PMC7643606__F1 NLRP3 inflammasome NLRP3 IL1B GSDMD PMC7827203__F3 Crosstalk of MDSC and Treg KYNU CD40 CCL5 CD80 LAG3 STAT3 PMC4250176__F6 MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells HEL-S-28 PTEN PMC7665128__F2 Calcium homeostasis and signaling in healthy neurons MCU ORAI1 STIM1 PMC6499991__F6 Proposed model of participation of SNHG1 in the regulation of signaling pathways that contribute sorafenib resistance in HCC cells CCND1 PTEN SLC3A2 MTOR PMC7948403__F5 Ferroptosis in Alzheimer's disease BACE1 VIT GPX4 PMC5485509__F2 Histone modifications regulate gene transcription involving renal fibrosis of diabetic kidney disease SMAD2 WDR5 PMC5945880__F1 Interferon-gamma (IFNG) canonical signaling pathway STAT1 JAK1 IRF-1 PMC10896652__F1 Relationship between NGF/TrKA signaling pathway and KOA peripheral hyperalgesia NGF PGP TRPV1 PMC2789789__F6 Scheme of the biosynthesis pathways for PC, PE, and PS in human P PC PSD PMC5769535__F1 Neurotransmitters signalling pathways in cancer RET NGF EGFR GDNF MTOR STAT3 PMC10869479__F3 P2X7-mediated signaling pathway NLRP3 APP RAC1 IL1B PMC11646805__F2 Diagram of endothelial cell mutant GAq signaling (p TSC2 TSC1 PTEN MTOR RHEB PMC5746412__F5 PKM2 in carcinogenesis and oncotherapy EGFR MTOR TRIM35 PMC6774422__F2 LRRK2 substrates involved in vesicle trafficking and synaptic transmission RAB35 RAB12 RAB43 RAB10 RAB24 RAB7L1 PMC8836911__F1 Theranostic Interpolation of Genomic Instability in Breast Cancer ATM CDK2 BRCA2 GRB2 RAD51 CDK4 PTEN CDC2 MTOR ATR BRCA1 CDK6 PMC6543238__F1 Tumor immunity by radiotherapy and immune checkpoint blockade CGAS APC TREX1 PMC4077896__F1 Autophagic structures in the regulation of MAPK phosphorylation EGF RAF1 PMC8927079__F2 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin EPHX1 AHR CYP1B1 CYP1A1 PAH PMC8927079__F1 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin AHRR AHR CYP1B1 EGFR CYP1A1 TF PMC8102695__F1 Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19 TFPI APC ACE2 PAF1 PMC3527701__F2 Mammalian N-end rule pathway.,,, N-terminal residues are indicated by single-letter abbreviations for amino acids UBR5 ATE1 UBR1 UBR4 NTAQ1 NTAN1 CP PMC6115613__F5 Summary of the signaling pathways involved in cell migration and invasion through p75NTR NGF MMP9 ARHA RAC1 ARF1 TIAM1 LEF1 MMP2 TWIST1 SRC KIDINS220 BDNF JUN TCF4 TRIO STAT3 PMC3043160__F4 Calcium-mediated mechanisms of cystic expansion RHO PMC6115613__F4 In some cases, migration and invasion are stimulated through NGF or proNGF upon activation of p75NTR and TrkA LEF1 NGF MMP2 TWIST1 MMP9 SRC ARHA KIDINS220 JUN TCF4 PMC6115613__F3 p75NTR and TrkB pathways TIAM1 MMP2 TWIST1 MMP9 ARHA RAC1 KIDINS220 ARF1 BDNF JUN TRIO STAT3 PMC8421567__F1 Emerging Role of T-Cell Immunoglobulin Mucin-3 in Breast Cancer: A Promising Target For Immunotherapy CXCL13 STAT3 PMC4485494__F3 Glycogen Synthase Kinase-3 in Insulin and Wnt Signalling : a Double-edged Sword? APC LRP5 LRP6 PMC5777890__F7 Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure HADHB DLG4 UBC HEL-S-67p NDUFS1 UQCRC1 IVD ACO2 NDUFA9 ACSL1 OGDH NDUFB6 SDHA UQCRQ SNCA HSPB2 MTIF2 NDUFA6 NDUFS3 ITGB1 NDUFB4 NDUFA3 SUCLG1 NDUFA10 CYCS SIGLEC9 PMC7599585__F3 Distinct mechanisms leading to Nrf2 activation in cancer cells KEAP1 FN3K TRIM25 PMC4074489__F4 p58IPK and UPR-associated inflammatory signaling pathways ATF4 EIF2A TRAF2 PMC7139386__F1 Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium UGDH HEL-S-19 GAL PMC6276109__F1 Breast Cancer Stem Cells: We’ve got them surrounded CXCR3 CYLD RELA EGFR SRC PTEN STAT3 PMC7783806__F8 Pathway signalling network generated from the 1000 most differentially methylated genes FZD3 SNAI1 CSNK2A2 PLK1 MAPK3 MAPK14 EPHB3 BCR POU1F1 GHR ASXL1 SRC BHLHE41 KCNN4 FZD10 MYOG ROCK2 TP53BP2 GPHA2 AREG MAPK7 MAPK10 LRP5 LTB4R RXRA PRKCB TSHR HEL25 TNFRSF1A IL11RA DUSP8 DUSP7 TRADD MAP2K4 CTBP1 EGFR IL11 PTEN NME2 THRA FOXP3 SIRT3 RARA RARB RXRB EPHB1 CBFA2T3 PTPRG NR1B3 PTPN1 GJB2 TRIP11 PITX1 NCOA1 MCHR1 NCOR2 KRT14 CCNK EGR1 PMCH PRKG1 PRKD1 ZNF652 NFATC2 EP300 ERBB2 NFKB1 MAP3K8 FLT3 PMC4091760__F2 Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1A signaling node AHR TBP PMC7778818__F5 The HO in the present case RUNX2 BMP2 SMAD2 PMC9138070__F1 Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle MAF KEAP1 DHFR PMC2148057__F8 Proteosomal degradation pathway HLA-A HLA-G PSME4 HEL-S-283 NEDD4 PMC9221178__F5 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression TBK1 TLR4 TRAF3 IRF3 TLR3 PMC9221178__F4 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression TLR4 IRAK1 APC TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TIRAP PMC2148057__F6 Sugar metabolism pathways in MCF-7 and ZR75-1 cells profiled by GenMAPP PC PRLR HEL107 PMC9221178__F2 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression TLR4 IRAK1 APC TRAF6 IRAK4 MYD88 MAP3K7IP1 IL1B TLR3 TIRAP PMC2148057__F5 GenMAPP view of energy production pathway in MCF-7 and ZR75-1 cells UCP1 UCP2 NDUFV3 NDUFB10 COX11 SURF1 NDUFS8 NDUFB5 SDHA SDHB COX7A1 NDUFS4 SDHC NDUFS6 NDUFV2 NDUFB9 NDUFB2 NDUFAB1 SLC25A4 SPIC NDUFC2 SLC25A6 COX3 COX17 NDUFB1 NDUFA3 NDUFB3 UCP3 CYCS PMC7366512__F1 Biomaterial-triggered complement activation drives early thromboinflammatory changes during hemodialysis HEL-S-62p C5AR1 FH C1S IL1B TF PMC2775119__F3 Ciliary functions of cystoproteins: mechanosensation and cell cycle control GIG8 PC CDK2 CDK5 CDK4 CDC2 CDK6 PMC9627224__F1 RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral ELF2 TLR4 ELF3 TLR9 ELF1 FOS TNF JUN IRF-1 PMC4039002__F9 Aggregate-Prone R120GCRYAB Triggers Multifaceted Modifications of the Thioredoxin System HDAC3 BAG3 HEL-S-101 INS PMC5224520__F7 Bridging topological and functional information in protein interaction networks by short loops profiling WEE2 E2F4 ECD RPA3 RBBP4 FLNA SPC24 SMAD2 GSK3B MYC NBN RALA SMAD4 RB1 MYH10 TFDP1 PRIM1 CDKN2A MDM2 MSH2 RAD21 ME2 HCFC1 ORC6 PSMA2 CDC45 MCM3 YWHAQ CDC20 HEL-S-80p MCM6 MCM2 CDC6 CDK2 PSMD6 ERCC2 PSMD1 TGFB1 MYH9 TUBA4A SFN TTK RRS1 CCNH VPS4B DBF4 CHD3 ORC3 ORC2 CDK7 FZR1 MAD2L2 ATM CCND1 DCTN1 CDK4 NUP107 PRKDC RBL1 CDC14B RAB11A GADD45G ANAPC2 RPA1 SKP1 RCC1 STAG1 PSMD3 RFC3 PTTG2 CCNB3 CREBBP BUB1B SMC3 SMC2 TYMS RAN SKP2 ESPL1 ANAPC10 PMC5173156__F6 Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factorB1 NR1i1 KLF4 CDH2 PMC4533315__F4 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis RPS27A ERBB2 ERBB3 NRG2 NRG1 UBB RNF41 MATK AKT3 PMC3670293__F1 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response LIF STAT3 PMC4533315__F3 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis PIK3CD PIK3R1 MAPK9 BAD BRAF MAPK8 BIRC5 MAPK3 SMAD2 TGFBR1 GSK3B MYC SMAD4 MSH6 CASP9 CCND1 MAPK1 MSH2 DCC JUN BAX FOS MAPK10 APC TCF7L2 ARHA RAC1 PIK3R3 CASP3 LEF1 RAC3 MAP2K1 PIK3CA BCL2 RAF1 LAT PIK3R2 AKT3 PMC6528196__F3 Predicted metabolic pathway of lignocellulose-derived inhibitors MOK COCH PMC5963631__F5 Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response EIF5B RPL32 RPS14 EIF2B1 RPL37 RPL9 RPS11 RPS15 EIF2S2 EIF3C RPS24 EIF3G EIF2S3 EIF3CL RPS25 RPL41 EIF4B RPL3 RPS23 PMC6968989__F2 Genetic pathways effected by mutations in maxillofacial bone tumours NF1 TRPV4 FGFR1 BRAF APC MDM2 GNAS PMC5883416__F2 Calcium in cell cycle G1/S transitioning via the MAPK pathway CCND1 CDK4 RB1 PMC2826554__F1 Beta-AR-dependent translation initiation EIF4E MTOR PMC6646053__F1 Antibody mediated complement activation CD59 CD46 VTN CD55 CR1 PMC3670293__F4 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response LIF TEF CDK9 STAT3 PMC6320836__F6 Status of proteins that participate in the autophagy pathway in glioblastoma ULK1 SQSTM1 EGFR UVRAG HIF1A DKFZp686F0183 PMC7722191__F1 Action of novel therapies in ET and PV EPO JAK1 MPL PMC3319453__F2 Insulin, IGF-I and IGF-II binding to IR and IGF-IR ELF2 BAD GSK3B PTEN EIF4E MTOR HSF1 IRS1 TSC2 TSC1 MDM2 GRB2 BAX PMC9414313__F2 Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer NUMB DKK3 NOTCH1 EZH2 STAT3 PMC2931413__F1 Hermaphroditism in Caenorhabditis nematodes.(A) The Caenorhabditis hermaphrodite gonad SDC1 SDC2 SDC3 PMC4831703__F1 The isoprenoid biosynthetic pathway (IBP, ) provides critical substrates for posttranslational modification of proteins that modulate cell signaling and regulatory processes RAP1A FDPS IPP PMC4520528__F2 B cell-derived cytokines direct the ensuing immune response LTA TNF PMC7073546__F4 Synthesis of capsaicinoids adapted from Mazourek et al CS AMT PMC4916380__F3 Central metabolic pathway in C. tyrobutyricum PTS HBD COG5 HPR PMC7290354__F5 PI3K/Akt pathway can be activated in different ways, as for example by G-protein coupled receptors (GPCRs), integrin or cytokine receptors and it represents a mediator between ECM and fibroblasts’ cell cycle TSC2 BAD TSC1 MTOR PMC11674331__F5 PAK1 and PAK2 in angiogenesis PAK1 RAC1 PMC11674331__F4 PAK1 and PAK2 in vascular remodeling PAK1 BAD RAC1 PMC8456215__F8 Emerging Targets in Type 2 Diabetes and Diabetic Complications SEMA4D NOTCH1 SRC HIF1A NOTCH3 PMC9163835__F4 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway HMGB1 TLR4 TFEB BCL2 BAX PMC7456540__F8 Working hypotheses of two opposing mechanisms that concomitantly drive and silence nerve injury-induced latent sensitization NPY TRPA1 TRPV1 PMC9163835__F3 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway WNT3A BCL2 PTEN RHEB BAX PMC3153965__F7 Network representation of altered cellular functions during colonization of the mouse colon by A CD3D HEL70 CD46 ATF2 HLA-DOB SPN HLA-DOA SELPLG F2 CD22 IL4 HLA-DMB CD3G PTPRCAP CP CD36 PMC6562438__F1 Schematic overview of pathways that are involved in desmoplasia in pancreatic cancer, including drugs and their targets VEGFC VEGFD CD44 VEGFA SMO MTOR VEGFB PMC9163835__F2 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway TSC2 HMGB1 TSC1 TLR4 TFEB MTOR STAT3 PMC9163835__F1 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway NLRP3 GCLC PTEN MTOR NQO1 PMC11674331__F6 PAK1 and PAK2 in the regulation of vascular integrity and permeability PAK1 CDC42 PMC6117929__F8 TGFB1 and E2 cause differential regulation of genes involved in extracellular matrix turnover MMP9 DPP4 TFPI2 MMP14 TIMP1 A2M MMP2 THBS2 RECK TIMP4 FAP TIMP3 CMA1 PMC8228183__F17 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology FGF2 NOX4 TGFB1 PMC12217801__F6 Proposed molecular mechanism by which PBM preserves erectile function in diabetic mice NGF MAX FGF2 BDNF PMC7081179__F1 7Alpha-Hydroxylase and (25R)26-hydroxylase pathways of oxysterol biosynthesis CYP27A1 CYP8B1 AKR1D1 AKR1C4 CYP7B1 HSD3B7 PMC9300166__F1 Mismatch repair and clinical response to immune checkpoint inhibitors in endometrial cancer POLE MSH6 MSH2 PMS2 PMC8228183__F20 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology NOX3 DUOX1 DUOX2 NOX4 NOX5 PMC3203699__F8 TRAF3-mediated positive and negative regulation of IFN signaling TANK IRF7 TRAF3 IRF3 MAVS PMC4115241__F5 Schematic drawing showed activated HFSCs contributed to SN development CD34 SOX9 PMC5014091__F1 Wnt/Beta-catenin upregulation in CRC and PDAC SULF2 APC GSK3B AXIN1 DVL2 PMC6200703__F2 Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis HMGB1 ATG12 ATG3 PTBP1 STX17 MTOR STAT3 PMC8411705__F2 Neutrophils in Glioma and Brain Metastases HMGB1 TLR9 MMP9 VEGFA CXCL8 TRPM2 CCL2 IFNG POLI PMC6635658__F7 Schematic model depicting the possible mechanisms of nobiletin-mediated inhibition of renal cancer cell proliferation YY1AP1 SRC STAT3 PMC9396497__F1 MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury SEMA3A NRP1 ARHA LINGO1 BRD4 PMC7789600__F2 Roles of lipoproteins in the exogenous, endogenous, and reverse cholesterol pathways LPL TG PMC9010872__F1 O-GlcNAcylation and Its Role in Cancer-Associated Inflammation PGM3 OGA OGT GFPT1 PMC3181220__F3 Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma TSC2 TSC1 PTEN EIF4E RHEB PMC4730267__F2 Gene members (green rectangle) in the PPAR signaling pathway that are regulated by maternal high fructose in the male offspring kidney at one day of age (red stars) PLTP UCP1 HEL-S-28 LPL APC2 PMC186370__F1 Spot 42 RNA mediates discoordinate expression of the E. coli galactose operon CRP GAL PMC1766780__F2 Cytokine signalling and the pathogenesis of severe combined immunodeficiency (SCID) IL15 IL7 IL9 IL2 IL-21 JAK1 IL4 PMC4817799__F4 Regulation of neural precursor plasticity within the classical neurogenic zones EGF ASCL1 APC GC PGC SHH PTEN PMC10921668__F8 The early ATL80-dependent response to WDS and its presumed function in retrograde signaling pathways MYB CAMTA1 ERF PMC8228183__F22 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology PAK1 MMP2 NOX4 EIF4E IL4 NOX5 NR1C1 STAT3 PMC3666312__F1 Current landscape for T-cell targeting in autoimmunity and transplantation HEL-S-171mP APC MTOR PMC8438230__F3 Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies PC GPT HEL-S-133P GLUD1 HK2 GLS PMC7170819__F2 Angiogenic factors and receptors involved in GBM angiogenesis EGFR MTOR STAT3 PMC8565990__F1 BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View BTK BASH LYN SYK PLCG2 MTOR CD79B CD79A CD19 PMC5203884__F1 p53 suppresses the cell proliferation mediated by the Rb-E2F pathway ATM CDK2 MDM2 CDK4 ATR CDK6 PMC8640807__F2 Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer ABCC1 PARP1 PGAM1 SIRT1 PMC7517653__F6 SFR changed substrate metabolism in ruminal epithelium FBP2 COL3A1 COL1A2 DHCR24 CYP24A1 COL1A1 HEL-S-104 HK2 PMC6305196__F9 Model for the CK-dependent photomorphogenic response in etiolated Arabidopsis seedlings DET1 RFWD2 PMC2975941__F2 Classical and non-canonical NFKB pathways BCR TRAF3 RELB CD40 LTBR PMC9038780__F10 Putative synergistic effects of MGO and aSyn in the midbrain IMPACT CAMK2A PMC10931770__F2 Positive and negative regulation of osteoclast differentiation JDP2 EBP NFATC1 PAX5 CX3CL1 ATF4 TRAF6 CXCL12 MAP3K7IP1 PMC4312878__F1 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond TLR4 IRF8 ATF3 PMC8656574__F2 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application FOXO3A CD44 EZH2 GDF10 CDH2 HAS2 PMC1446957__F5 In vitro keratinocyte mitosis EGF EGFR GRB2 SHE PMC8656574__F1 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application YAP1 BCL2 LATS1 CEBPA EZH2 PMC9304887__F1 Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery AGO2 EGFR MYC STAT3 PMC6409899__F1 Models of replication-coupled ICL repair MCM3 MCM5 MCM6 MCM2 FANCD2 SLX4 FANCM MCM7 PMC6437054__F1 Interaction map and annotation enrichment of the newly synthesized mazEF-related proteins CLPX RHO PMC6409899__F3 The Fanconi anemia pathway suppresses R-loop-associated genome instability FANCD2 SETX FANCM BRCA1 PMC8009801__F3 Identification of small molecules targeting the Hippo-TAZ/YAP pathway BTC RUNX2 AREG MYC LATS1 PMC9108399__F2 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers SNAI1 KLF4 SRC ARTN MTOR PMC9108399__F1 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers RET GDNF PSPN ARTN NRTN GFRA3 GFRA2 GFRA4 PMC7532108__F7 Proposed pathway of recovery of R28 cells, induced by hPMSC-derived exosomes, after hypoxic damage UBA2 GSK3B PMC8781453__SF1 Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/Beta-Catenin Signaling Pathway DKK1 PMC2720607__F2 Principal enzymes and substrates of the folate pathway involved in formation of tetrahydrofolate (THF) and its utilisation in the thymidylate cycle DHFR FPGS DHPS PMC4218690__F1 Honokiol and ionizing radiation (IR) affect Notch signaling MYC MDM2 CDC2 BAX PMC3605582__F1 Key mediators of innate and adaptive immunity, development, and signalling TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 IL12A C4A TLR7 TLR4 PREB TLR5 IRF7 LTB IRF3 TNF TLR1 IL23R IL12RB1 TLR3 IL12B HLA-B HLA-A LTA STAT4 IL23A TYK2 STAT3 PMC3631253__F4 A Protein Prioritization Approach Tailored for the FA/BRCA Pathway SPO11 HEL2 HEPACAM DMC1 ID4 DBF4 ORC2 KIF11 CCNE1 PRC1 NEK3 SMC2 MDM2 STK11 ZWINT CEP250 STAG3 KNTC1 CHFR NCAPD3 PMC2574638__F8 Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s Disease BAD IL16 APP PMC4312878__F3 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond COX2 IL18 IL16 HNRNPAB CCL5 STAT3 PMC10748332__F5 Signaling pathways involved in neuroprotective mechanisms FOXO3A PPA2 TNF MTOR PMC9178153__F2 Autophagy in muscle regeneration: potential therapies for myopathies PINK1 ULK1 TFEB PAX7 DKFZp686F0183 SIRT1 MYOG PMC4838159__F1 Five significant subnetworks of the N-group, associated with (A) glutathione metabolism (B) leucine and isoleucine metabolism (C) pancreatic cancer (D) calcium signaling pathway and (E) the mitogen-activated protein kinase pathway HEL-S-89n GSTA4 AACS PPP3CA VEGFA HMGCL RAC1 HEL-S-21 CRK HSD17B10 HEL-S-22 CALM1 GSTM2 MGST2 TXNDC12 GPX3 MGST1 MAPK6 NFKB1 ECHS1 STAT3 PMC10506243__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide (LPS) MYB MYH9 EIF4A1 BAZ1B CAP1 ENO1 HSPD1 HEL-S-87p LMNA RANBP2 DDB1 RPN1 MDH2 HEL-S-68p KMT2C RANBP1 RPS27A USP14 ANXA2 HNRNPC IMPDH2 HEL113 DDX5 ACTN4 PMC4729166__F2 Schematic illustration of the molecular processes leading to apoptosis in renal proximal tubular epithelial cells MYD88 FADD BAX PMC4729166__F1 The activation of the NFKB transcription factor pathway by liposaccharide (LPS), TNFA, high mobility group (HMG)B1, and polymicrobial sepsis CD14 HMGB1 LBP TRAF6 MYD88 PMC8773516__F2 Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome SMAD2 TGFBR1 TGFBR2 SMAD4 PMC6004386__F1 Binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation TLR4 S100A8 TRAF6 S100A9 MYD88 PMC9525711__F7 Schematic depicting the role of TLB on AD TLR4 TRAF6 MYD88 SIRT3 PMC11856057__F2 Signal transduction in the Hedgehog (Hh) signaling pathway BOC KIF7 DISP1 SUFU GLI3 GSK3B KIF3A SMO GAS1 PMC11856057__F1 General mechanisms involved in Notch signaling MAML1 MAML3 MAML2 ADAM10 ADAM17 HES1 PMC9200284__F2 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy ADA AK1 PMC9200284__F1 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy TDG DNMT3B PMC9236768__F7 Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells RUNX2 BMP2 SMAD4 SMAD1 DKFZp781O1323 PMC8246373__F2 Activity-Dependent Gene Expression in Neurons PC ARHA POR TF PMC1383515__F6 Proposed tentative mechanism underlying MAFA-mediated selective inhibition of FcɛRI-induced cytokine gene transcription FYN FOS JUN PMC6928935__F1 The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway RICTOR MTOR DEPTOR ELF4 PMC9123899__F2 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) IL1R2 IL1B IFNG STAT3 PMC6218675__F1 Nuclear envelope proteins and their potential roles in EDMD physiopathology LBR SMAD2 GRB2 SMAD4 ARHA HEL-S-61 PMC9123899__F1 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) IRF9 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IFNG IL10RB IFNLR1 PMC7270498__F2 ncRNAs Regulate Cell Death Pathways to Influence HCC ChemoresistanceMultiple miRNAs and lncRNAs act as mediators of the autophagic process in HCC cells by regulating the PI3K/Akt signaling pathway TP53INP1 TNFSF6 ULK1 ATG16L1 ATG12 PTEN MTOR DKFZp686F0183 FADD BAX PMC7270498__F1 ncRNAs Affect Drug Efflux and Nrf2-Dependent Drug Metabolism in HCC CellsVarious miRNAs and lncRNAs can regulate intracellular drug concentrations in HCC cells by targeting drug efflux pumps IGF1R IGF1 KEAP1 DHFR ELL PMC8583788__F2 Disentangling Mitochondria in Alzheimer’s Disease NRF1 TFAM NR1C1 SIRT1 SIRT3 PMC8710681__F3 Mitotic and DNA Damage Response Proteins: Maintaining the Genome Stability and Working for the Common Good ATM MDM2 XPA PMC4766464__F9 Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis ATF4 EIF2A BAX PMC524243__F1 Simplified model of insulin signaling IGFBP1 PDK2 GRB2 SYP PMC4423889__F3 Analysis of Glioblastoma Patients' Plasma Revealed the Presence of MicroRNAs with a Prognostic Impact on Survival and Those of Viral Origin TH CDA CEBPE SPIB MYC RING1 PMC3270444__F5 Putative inhibitory pathway of LPS-activated inflammatory signaling responses by peptide K5 TBK1 TLR4 FOS SRC TRAF6 SYK IRF3 MYD88 PMC7279404__F2 Summary of the liquid biopsies activating chemoattraction signal pathways for recruiting immune cells in NASH/NAFLD TLR9 CXCL10 MSC TNFRSF10B CYP2E1 PMC9507402__F2 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage GSDMC GSDMB GSDMD DFNA5 PMC9507402__F3 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage NLRP3 MCC GSDMD PMC11724515__F8 Sirtuins 1/3/4/6 exert disparate influences on stem cell differentiation and insulin secretion PDX1 SIRT4 SIRT6 SIRT3 PMC7288973__F8 Schematic diagram depicting the anti-PCa mechanism of C10 CASP3 BCL2 IL6 CASP8 BAX PMC11724515__F1 Mechanism of Sirtuins in the occurrence and development of obesity ADIPOR1 SIRT7 SIRT6 TG SIRT1 FOXO1 STAT3 SIRT3 PMC11724515__F3 Mechanisms by which the FTO and TBX15 genes regulate obesity and osteoporosis RUNX2 SIRT6 MSC PMC11724515__F2 Specific mechanism by which Sirtuins regulate the occurrence of osteoporosis SIRT2 SIRT7 RUNX2 NFATC1 SOST ARX SIRT1 SIRT3 PMC11724515__F5 Oestrogen, melatonin and NPY on obesity and bone NLRP3 NPY RUNX2 SIRT6 SOST LEPR JUNB SIRT1 SIRT3 PMC4889582__F2 TLRs reside on the plasma membrane or intracellularly on endosomes and act via the MyD88 or the TRIF pathway leading to the activation of downstream signaling pathways TLR8 TLR5 TLR7 TLR4 TLR9 IRF3 MYD88 TLR1 TLR3 PMC11724515__F4 Vitamin D on obesity and bone NLRP3 TG SIRT1 PMC7805242__F5 MiTF in osteoclast differentiation CTSK NFATC1 OSCAR DCSTAMP CLCN7 OSTM1 GPNMB PMC11724515__F6 SIRT1 regulates the balance between lipogenic and osteogenic differentiation of mesenchymal stem cells ADIPOR1 RUNX2 SIRT1 PMC9204147__F4 Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial CCR2 BMP3 TNFRSF14 ANGPTL4 TSHZ1 MMP9 IL25 TNF PDGFC VCAM1 F3 FGF10 LPL CD40 GH1 CD36 PMC5279777__F3 Transcriptome Analysis Reveals Comprehensive Insights into the Early Immune Response of Large Yellow Croaker (Larimichthys crocea) Induced by Trivalent Bacterial Vaccine NLRP3 NLRP1 TRAF6 ARHA CCL4 IRAK4 PMC7175546__F2 DNA damage and replication checkpoints TIMELESS ATRIP ATR PMC2943133__F2 Toll-like receptor (TLR) signalling is mediated by at least two distinct pathways TRAF6 IRF3 ECSIT MIP MYD88 TIRAP PMC7175546__F1 Participation of WEE1 kinases (Cdk1 inhibitors) and CDC25 phosphatases (Cdk1 activators) in the regulation of the activity of Cdk1 kinase during G2 and M phases WEE1 ATRIP CDC2 ATR PMC6711563__F3 Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole PTCH1 ABCC1 SHH CCND1 SMO MTOR SOX9 PMC8507016__F2 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) MMP7 APC FAP LRP5 LRP6 BCL9 PMC11923325__F5 Downregulation of TLR signaling CD14 TLR4 IRAK1 SIGIRR TRAF6 IRAK4 MYD88 SOCS1 TIRAP PMC8507016__F1 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) MMP7 APC LRP5 BCL9 PMC3649699__F2 Cerebral ischemia-reperfusion activates two major signaling pathways which exert an effect on NOD IL16 F7 BCL2 PMC8875540__F3 Transcriptomic Analysis of Fish Hosts Responses to Nervous Necrosis Virus SMCHD1 RSAD2 DHX58 EBI3 EPSTI1 SACS NUP133 CD8A FUS CTSZ PMC8507016__F3 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) IL7 IL6 CCL3 PMC6711563__F2 In an adult cell, Hh pathway is always silent or poorly activated SUFU PTCH1 SHH SMO PMC9083465__F11 Integrating Lipidomics and Transcriptomics Reveals the Crosstalk Between Oxidative Stress and Neuroinflammation in Central Nervous System Demyelination CYBA PC TG PMC8909644__F3 Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming GSTM2 GLS PMC11240772__F1 Active Canonical Wnt/Beta-Catenin Signaling Pathway APC LRP5 LRP6 PMC11240772__F2 Inactive Canonical Wnt/Beta-Catenin Signaling Pathway APC LRP5 LRP6 PMC11923325__F3 Involvement of TIR domain-containing adaptors in TLR signaling pathways CD14 TLR5 TLR7 TLR4 TLR9 IRAK1 TRAF6 MYD88 TLR1 TLR3 TIRAP PMC11923325__F2 Structure and mechanism of TLR4, highlighting both MyD88-dependent and MyD88-independent pathways TLR4 IRF3 MYD88 PMC5662721__F4 Type I interferon pathway gene network predicted by IPA analysis PRKCI RSAD2 TINAGL1 POSTN CREB1 PTEN HEL-S-104 HMGCR NNAT PI3 SERPINA12 HTATIP2 CEBPZ PKN2 LBP KITLG TRIP11 CIDEA PRPF4 GLS SLC4A7 PMC3754482__F6 Glycocode model: 3-OST-5 and 3-OST-6 regulate distinct cell signaling pathways for ciliogenesis and cilia motility FGFR1 FGF8 KIF3B RFX2 PMC5477485__F2 Conserved insulin-signaling pathway in the ovary IRS4 IGF1R IRS1 PMC4281383__F4 Differential expression in LCI IFIT3 PARP14 TANK IFITM3 IFITM2 RPSA IFITM1 ZBP1 MX1 IFNG ZC3HAV1 STAT1 ISG15 OAS1 TLR7 RPS27A IRF-1 PSMB8 IL1B BAX STAT2 IRF7 IRF9 RPS3A ADAR RPL17 C1QB TNFSF10 PIAS1 TYK2 IFI35 IFIH1 SOCS1 IFIT1 PMC3990718__F9 Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis HEL-S-62p NLRP3 IRF3 IL1B MAVS PMC7460884__F3 MCSs regulating cholesterol trafficking to the ER NPC1 VAPB VAPA NPC2 PMC6213163__F7 Luteolin and Toll-like receptor signaling pathway TLR5 CSF1R CCL7 CD68 PMC7579710__F6 Potential mechanisms of PB2‐induced apoptosis in OS cells BCL2 CPD BAX PMC6213163__F5 Gene transcription pattern related to the TLR signaling pathway in white adipose tissue CD14 CTSK TLR9 TRAF6 IRAK4 IRF3 IL6 RAC1 TNF TLR3 CPO PDC LBP CD40 FADD TIRAP PMC5477485__F1 Insulin-dependent signal transduction pathways TSC2 RICTOR BAD TSC1 FYN MDM2 GRB2 PTEN EIF4E MTOR RHEB PMC6779911__F6 Configuration of organellar GS-GOGAT cycles and split-organelle arginine biosynthesis AGK PRODH2 CIT ASL CP PMC9455833__F2 Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets FABP5 IL6 HEL-S-104 IL1B PMC5399176__F8 Proposed mechanism for ion flux-dependent regulation of the NLRP3 inflammasome NLRP3 IL1B PMC5701650__F1 STRESS ADAPTATION YAP1 HSF1 PMC7920050__F1 Biogenesis of exosomes RAB27A RAB27B PMC5843510__F8 Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity IRS4 PMC8330548__F2 Cadmium Exposure on the Immune System and Immunoregulation NLRP3 NR1i1 KEAP1 CD40 PMC2935201__F3 Platelets, Petechiae, and Preservation of the Vascular Wall EGF EGFR VEGFA BDNF PMC2917385__F1 Tumor Microenvironment in Non-Small Cell Lung Cancer EGFR PTEN MTOR PMC7695978__F1 miR-363 Alleviates Detrusor Fibrosis via the TGFB1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM SMAD2 COL1A2 SMAD4 PMC6357186__F6 KRT19 and Wnt/beta-catenin/Notch signaling pathway in colon and breast cancers NUMB LEF1 KRT19 RAC1 PMC10778261__F8 Modulation of PI3K/AKT/TORC1 signaling pathway and AMPK activity downstream of M2 mAChR activation by APE or N8 in U251 and GB7 cell lines ULK1 MTOR PMC7694542__F3 Conservation of signalling pathway proteins in Myxococcaceae CARF EBP PS1TP5BP1 PMC7379745__F1 Macrophage M2b polarization TRAF3 TRAF6 SYK IRF3 PMC2790417__F10 Summary of proposed role for Foxa2, Nodal and Hh signalling pathways in ventral CNS development NTN1 NODAL FOXH1 FOXA2 PMC7947301__F1 Regulatory activities of nuclear receptors on the NLRP3 inflammasome priming and activation steps NLRP3 IL1A IL18 NR1i1 TXNIP BRCC3 PANX1 IL1B GSDMD CD36 PMC6459338__F3 Classical and “back-door” pathways of androgen biosynthesis STS CYP11A1 AKR1C1 CYP7B1 HSD17B2 UGT2B17 HSD17B3 AKR1C2 CYP17A1 UGT2B15 PMC7921639__F1 Metrnl regulates the intracellular signaling pathway HDAC5 METRNL STAT3 PMC8389593__F4 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway PCP4 CYP11B2 PMC3074690__F1 The current model of the blood coagulation cascade TFPI FIBIN PMC8389593__F3 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway GSK3B LRP6 CYP11B2 PMC8389593__F2 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CACNA1H ATP1A1 KCNJ5 CYP11B2 PMC8389593__F1 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CAST STAR CYP11B2 PMC5498918__F1 Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity PRDM16 UCP1 HES1 PMC8389593__F8 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway ZNRF3 MED12 GSK3B LRP6 PMC8389593__F5 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway HSD3B1 PARP1 CYP11B2 PMC2901643__F2 Putative signaling components in fungal mating interactions PRF1 TF CDC42 PMC3206202__F9 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice BAD BAX PMC5393036__F7 Schematic model of NKILA functions during the invasion-metastasis cascade in NSCLC SMAD2 SMAD4 PMC4457722__F5 Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment LMNA RAN PMC11580298__F3 Network-based hub biomarker discovery for glaucoma DERA GMDS LHPP ABO ARHGEF3 GLIS3 PTHLH CLU RERE FARS2 EVI1 ATXN2 SMG6 FMNL2 FNDC3B PDE7B PMC6779911__F2 Functional annotations of highly nitrate-sensitive (HNS) gene set and model of nitrate assimilation and regulatory components in Phaeodactylum tricornutum CS NONO NAT2 TG TF PMC11740368__F5 Pers expression regulates tumorigenesis WEE1 CCNB1 MDM2 BMI1 MTOR PER2 PER3 PMC4519914__F6 Protein–protein interaction (PPI) network and ingenuity pathway analysis (IPA) EIF2S1 TBK1 TANK PBDC1 DDX3X IRF3 EIF4E EIF1AX EIF4EBP1 BRCA1 EIF4G1 EIF3C ELAVL1 PABPC1 SRC NCOA1 SP1 PMC5814291__F3 FOXC1, the new player in the cancer sandbox FOXC1 EGF PIN1 PTCH1 EGFR SMO PMC5601978__F4 Physiological functions of ataxin-2 AGO1 ELF3 ATXN2 EIF4E RPS6 RORA MTOR INPP5A EIF4G1 PMC11740368__F6 Cancer stem cell generation and mechanisms of PERs action on cancer stem cells PER2 PER3 PMC3295063__F2 NFKB in Aging and Disease BCL10 TRADD ATM LCK ZAP70 TRAF6 MYD88 TRAF2 FADD ACR PMC8599992__F10 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability RBPJ SLX4 PIAS1 SLX4IP TF TERT PMC9406090__F2 Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge LIN28B DIS3L2 TUT4 DROSHA LIN28A TUT7 PMC2844177__F9 P38 MAPK signal transduction in melanogenesis USF1 DCT MC1R PMC8777575__F3 Gold complex auranofin: new perspectives for cancer therapy HMGB1 APC BAX PMC8777575__F2 Gold complex auranofin: new perspectives for cancer therapy FOXO3A EIF2A BCL2 ABCG2 MCL1 MTOR BAX PMC4028208__F9 A summary schematic of the lansoprazole-induced AhR/Cyp1a1/Nrf2 pathway in the liver UGT1A3 AHR CYP1A1 PMC1475884__F2 TNF receptor (TNFR) pathway of signaling TRADD TRAF1 TRAF2 FADD PMC11831484__F10 Fatty Acid Oxidation‐Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica‐Induced Pulmonary Fibrosis CPT1A PFKM HK2 ACOX1 PMC4640673__F2 ECM receptors in neuronal structure, synaptic plasticity, and behavior VLDLR ARHA DAB1 PMC4679480__F8 Green Tea component EGCG, Insulin and IGF-1 promote nuclear efflux of atrophy associated transcription factor Foxo1 in skeletal muscle fibers IGF1 IRS1 FOXO1 PMC4346735__F1 Krüppel-like factor KLF10-mediated regulation of transforming growth factor (TGF)B signaling pathway in CD8+ and CD4+ T cells SMAD2 KLF10 FOXP3 PMC9339612__F4 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer MDM2 PMC9339612__F3 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer LIF JAK1 RAN STAT3 PMC9339612__F2 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer TGFBR1 SP1 PMC8379308__F1 Herpesviruses and the Type III Interferon System TLR9 STAT2 IRF7 IRF9 TRO IRF3 IFNAR1 TLR3 MED23 STAT1 ANKRD1 TYK2 JAK1 MAVS PMC9339612__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer RAB11A RFWD2 STAT3 PMC5386389__F8 ATG5-ATG12 involvement in FMDV-induced type IIFN signal pathway TBK1 ATG12 TRAF3 IRF3 DKFZp686F0183 PMC4310451__F3 Differential effects of leptin and adiponectin in vascular endothelium ADIPOR2 VCAM1 CRP STAT3 PMC11603874__F11 Anti-TNFR2 bs-Ab mechanism of action MSC EGFR ARG1 PMC7882969__F2 Signal pathways related with androgen synthesis in polycystic ovary syndrome (PCOS) WNT4 APC GSK3B CYP11A1 HSD3B2 CYP17A1 STAR INSR PMC4661210__F7 JNK1 exerts kinase activity on several transcription factors and BCL2 family proteins through phosphorylation or ubiquitination FOS ATF2 BCL2 MCL1 BMF JUN BAX PMC4661210__F6 Activation mechanisms of the ASK1 signaling pathway leading to JNK and p38MAPK phosphorylation TRAF5 FOS TRAF6 TNF TRAF2 PMC4661210__F3 Activation mechanism of NRF2 and downstream transcription events ABCC3 GCLM EPHX1 CES1 KEAP1 GCLC HMOX1 NQO1 NQO2 ABCG2 ABCC6 ABCC2 SRXN1 PMC6567798__F1 LncRNAs regulate p53 signaling pathway through MDM2 ATM MDM2 PMC3423855__F1 Hepatocellular processing of, and immune modulation by, the precore protein MYD88 MAL PMC7191303__F1 Hippo–YAP1/TAZ pathway in cardiac biology ERBB4 YAP1 NF2 AMOTL1 NRG1 LATS1 LATS2 FAT4 ARID1A PMC5546324__F6 AKT/PKB Signaling: Navigating the Network TSC2 EGF IGF1R IGF1 GAB2 EGFR INS EIF4E TBC1D4 IRS1 RHEB PMC6237576__F3 Contributions of PCAF‐induced acetylation to the development of liver injury and mediators of inflammation APC KLF10 SIRT1 FOXP3 PMC6492362__F7 Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition via the Hippo signaling pathway in human bladder cancer HEL-S-66 LATS1 LATS2 PMC8905633__F4 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation CCR5 CCR2 MAPK8 MAPK3 MAPK14 BCL2L1 AGTR2 APP SRC IL2 MAPK1 CHRM2 JUN NR3C1 IL8RB TNF HEL-S-162eP CASP3 P2RY2 CHRM3 CHRM1 CXCR4 PIK3CA HTR2A ADRA2B STAT3 PMC4486162__F1 Apoptosis: role in myeloid cell development TRADD FADD BAX PMC6237576__F4 Contributions of PCAF‐induced acetylation to the development of hepatocellular carcinoma and liver cancer tumour growth HEL-S-30 PTEN MTOR BAX HEL-S-162eP PMC8905633__F7 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation PLN EGFR MAPK3 APP PIK3CA SRC MAPK1 TNF JUN STAT3 PMC7296212__F6 Mechanism of NRF2 activation by oxidative stress KEAP1 RBX1 PMC3861981__F5 A simplified schematic diagram of the neural circuitry underlying eyeblink conditioning CS PC GC PMC10708062__F8 Analysis of DEGs involved in carbon fixation under osmotic stress RPIA RPE MDH2 PMC3660156__F4 Tumour dormancy and clinical implications in breast cancer EGF PLG EGFR PMC5538252__F4 Sepsis and septic shock MPO PMC6566596__F4 Cross-talks between tumor and immune cells determining chemo-immune-resistance PGP TF PMC8921626__F4 Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach AOX1 CCNG1 PHLDA3 BTG2 PPP1R10 ID1 UGT1A1 HEL-S-22 PMC12006732__F3 Communication between the gut microbiota and other organs IL13 FXR1 IL22 FGF19 FGFR4 TNF CYP7A1 PMC11447943__F2 Main interactions of TRPC5 channel with signaling proteins in a cellular context NHERF2 GDA TRPC5 ORAI1 STIM1 NHERF1 PMC3046044__F1 Molecular mechanisms involved in nasopharyngeal carcinoma (NPC) development UNK PTEN PMC3905242__F1 MRE11 complex: starting from the ends ATM BLM CDK2 CDC2 ATR MRE11A PMC6920374__F6 The role of Wnt signaling in hiPSC-CM differentiation MESP1 KDR PDGFRA SOX17 FOXA2 PMC3905242__F4 MRE11 complex: starting from the ends ATM RAD50 H2AX MRE11A PMC6343537__F2 Putative pathway for antagonistic Rab35/Arf6 regulation in presynaptic terminals ACAP2 TBC1D24 RAB13 PMC4054936__F2 Tonic regulation of vascular permeability TIAM1 PAK1 HGF APC RAC1 PMC8509209__F6 LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures APC GSK3B PMC10242022__F1 Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis BCKDK PPCS PPCDC PANK1 HEL-S-162eP PMC8282538__F6A Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells TAF1B GTF2H4 PPCDC PPT2 FPGS MX1 HLA-C HLA-F SMVT CTNS NAGPA PPCS SLC2A3 NMNAT2 GBP2 CLN3 ACP2 COASY MOCS3 GPHN PMC6489690__F4 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer LZTS1 LATS1 LPA CDC2 MOB1A PMC6489690__F3 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer SMURF2 AXIN1 WIF1 PMC8304577__F9 Analysis of Phytohormone Signal Transduction in Sophora alopecuroides under Salt Stress BHMT2 CTH PDC MVD EBP MVK DES DLAT HMGCR TARP HEL-S-162eP PMC4824422__F3 Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling PDE1C CACNA1B BRAF CHRNA7 GRPR GNA14 IL1R2 PTGER3 DRD1 MAPK8IP2 CACNA1C NF1 ERBB4 GRIN1 CAMK4 NOS2 NTRK1 ADRB2 HTR7 CACNA2D3 HRAS CACNA1F PLCB1 CACNA1I PLN ADORA2A CACNA1H AVPR1A CACNA1G PRKCB CHRM3 OXTR ATP2B2 GRB2 GNAS RAF1 HTR2A BDNF MEF2C RPS6KA2 P2RX4 PMC3931400__F3 Signaling by leptin, Wnt, and Beta-catenin in the regulation of Beta-cell proliferation SOCS3 PITX2 APC GSK3B CCND1 TCF7L2 PTEN IRS1 CCND2 PMC3931400__F2 Signaling by EGF and PDGF in the regulation of Beta-cell proliferation EGF EGFR ERBB3 HBEGF PTEN EIF4E RHEB TSC2 TSC1 ERBB4 BTC ERBB2 EZH2 TGFA PMC5108608__F1 Diagram of possible GPC3-mediated signaling pathway in HCC progression.Abbreviations: GPC-3, glypican-3; HCC, hepatocellular carcinoma; P, Phosphorylation BAD GPC3 SMAD2 MMP9 MYC SMAD4 PTEN RAC1 PMC8789910__F7 Illustration of proposed mechanism RAC1 AURKA INPP5E CDC42 PMC8940216__F5 Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis CCR2 MYD88 TNF IL1B PMC9922515__F7 Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway ATF4 MYC AAMDC SESN2 PMC5485992__F2 Neuronal defense systems GCLM FGFR1 APP MTOR BDNF PRX TFAM NQO1 PMC11130840__F1 PCP-mediated signaling pathway in Drosophila and mouse DVL2 CELSR1 CELSR3 VANGL1 DVL3 DVL1 CELSR2 PMC10620037__F4 IL-37 inhibits hepatocellular carcinoma (HCC) TSC2 MTOR RHEB PMC9112923__F5 Identification of Alzheimer’s Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing EGF CDKN1A MAPK8 PRKAA2 EGFR MYC GRB2 MAPK14 RAF1 SIRT1 TF PMC10620037__F3 IL-37 inhibits liver fibrosis TBR1 ID1 SMAD1 PMC4564160__F3 SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells HEL-S-125m AMPD3 ETFB HERC1 SACS HEL-S-99n ATXN2 KIAA0408 HSPD1 PARG KRT9 FUS PMC11901428__F1 Host-microbiota interactome in IBD TLR5 S1PR2 AHR S1PR1 S1PR3 S1PR5 S1PR4 PMC8282538__F5A Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells TRIM13 AKAP12 TRIM16 PEG10 TSPAN15 SPATA20 SOX17 DEPP1 AGL PMC11899125__F3 Immune-checkpoint signaling LCK CD80 PMC11899125__F1 Signal Transduction Pathways of Co-inhibitory Immune Checkpoints BTLA CD80 TIGIT LAG3 CEACAM1 PMC11899125__F6 Primary resistance CXCL10 EGFR CXCL9 PTEN CTLA4 LAG3 TOX B2M MTOR PMC4765374__F1 Molecular mechanisms of ethanol-associated OESCC CD14 TLR4 SHH CYP2E1 ALDH2 PMC5974248__F3 Involvement of optineurin in nuclear factor kappa B (NFKB) signaling TBK1 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 OPTN PMC2864807__F2 PPAR Signaling Pathway and Cancer-Related Proteins in Celiac Disease-Associated Tissue Damage FABP2 APOC3 ACADM PMC2066195__F10 IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice TLR4 IL1R1 MYD88 IL1B PMC9453641__F1 Gamble between oncolytic virus therapy and IFN STAT2 IRF9 IFNGR2 TYK2 IFNAR2 STAT3 PMC8759529__F1 Histiocytoses converge through common pathways ALK PTPN11 CCND1 MTOR CBL PMC12104182__F3 Possible mechanisms by which periodontal pathogens may promote activation of the Wnt/Beta-catenin pathway during oral carcinogenesis APC GSK3B DVL1 PMC2794543__F8 Activation of Wnt/Beta-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells GRB2 WNT10B PMC9029738__F2 Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network TSC2 TSC1 MAP1B MMP9 GSK3B ARC EIF4E MTOR PMC2751986__F7 Rev-erbA/PGC-1A pathway regulating heme homeostasis ALAS1 NRF1 RORA PMC3622753__F1 Intracellular S100B on cell proliferation, differentiation, survival and motility EGF PDK2 CCND1 SRC ARHA CDK4 S100B CDC42 TRIO PMC7930375__F1 Vitamin D (both D3 and D2) metabolic pathway and its physiological impact on immune cells VIT NR1i1 CYP2R1 CYP27B1 PMC12010983__SF1 Graphical abstract FACL4 FTH1 SLC7A11 PF4 CXCL3 EZH2 PMC4453272__F2 Fragile X Mental retardation protein regulates several cellular functions in the dendritic spine NF1 TSC2 AGO1 LIMK1 TSC1 PTEN DSCAM RHEB PMC9658244__F3 IL-33/ST2 Pathway in Cerebral Malaria CXCL10 IL33 CCL2 IL1B PMC9658244__F2 IL-33/ST2 Pathway in Cerebral Malaria IL33 CD40 CD80 IL5 IL1B PMC8013494__F1 COVID‐19 and Liver Cirrhosis: Focus on the Nonclassical Renin‐Angiotensin System and Implications for Therapy ATR ACE2 PMC8964154__F7 Identifying Active Substances and the Pharmacological Mechanism of Houttuynia cordata Thunb. in Treating Radiation-Induced Lung Injury Based on Network Pharmacology and Molecular Docking Verification EPO BCR CYC1 APP PTEN HEL-S-20 ITCH CD19 PMC4171726__F4 Endothelial versus cancer metabolism GIP GLDC HEL107 HEL-S-162eP GLS PMC9494650__F6 Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage HEL-S-26 AGA ADA ACLY PMC9552878__F4 Two facets of receptor tyrosine kinase in cardiovascular calcification—can tyrosine kinase inhibitors benefit cardiovascular system? FGF21 FGF23 FGFR1 RUNX2 MSX2 PMC6316616__F2 HSV-1 deregulates host miRNAs CFH ARHGAP21 GRSF1 IRF-1 CDC42 IFNG PMC6444510__F1 cGAS-STING pathway TBK1 CGAS IRF3 ARF3 PMC7203694__F8 Plausible mechanism of CeO2-induced apoptosis of human colon cancer cells (HCT 116) by ROS-generated mitochondrial-mediated pathway CASP3 APAF1 MDM2 BCL2 PMC5486401__F2 Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases TRADD RELA RELB FADD BAX PMC9520222__F8 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway COL3A1 COL6A1 COL1A1 SOX9 CDC42 PMC11566475__F9 Metabolic pathway gene association network CDC20 WEE1 TUBB SC5D CTGF PMC7550629__F3 TRP- small GTPases signaling pathways interplay in aberrant tumor vascularization TRPC1 TRPV4 TRPC6 ARHA TRPM8 PMC8458655__F9 Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors HOXA9 FXR1 ABCC1 REV3L AK4 STAT3 PMC8945564__F6 Quantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion PC GAA PMC6909348__F2 CLCA1 on mucus production CLCA1 MUC5AC SPDEF PMC4303633__F5 Metabolic scheme of ectoine, glutamate and proline synthesis and catabolism inferred from the Nitrosopumilus genomes CS PC ECD PRODH PMC3920008__F4 Novel regulatory pathway of intracellular lipid homeostasis CYP27A1 CYP8B1 PMC9526673__F6 Identification of Interleukin-1-Beta Inhibitors in Gouty Arthritis Using an Integrated Approach Based on Network Pharmacology, Molecular Docking, and Cell Experiments TH PELO PMC6187079__F1 Mammalian autophagy-lysosomal pathway (ALP) ULK1 ATG12 ATG3 SQSTM1 AMBRA1 ATG101 ATG10 MTOR EVA1A NBR1 TFEB NOTCH1 ATG14 PMC6955744__F5 TGFB signaling pathway with mediators in the TGFB pathway and BMP pathway are depicted, adapted from IPA NR1i1 TLX2 NODAL PITX2 HOXC8 GRB2 GSC SKI PMC11910004__F7 Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway EGR1 THBD NFATC1 SMAD2 SMAD4 FOXO1 STAT1 CASP3 PIM1 MMP2 VCAM1 CDK4 SELE TF STAT3 BAX PMC3033158__F3 Signal pathways in systemic regulation of hepcidin HAMP GDF15 HFE TF TFR2 PMC11603874__F8 Signals from Mb-TNFA/TNFR2 stimulate HIF-1A, CXCR4, and PD-L1 CD47 ATF4 CXCR4 EGFR MYC VHL CXCL12 REL BCL9 JUN STAT3 PMC8831980__F2 Fibroblast growth factor 8 in cartilage development and disease APC FGF8 GRB2 RAC1 MTOR PMC11603874__F7 TNFR2 supports BCSC growth and development CD47 SOX2 EGFR MYC SNAI2 CD44 HIF1A TRAF2 STAT3 PMC11603874__F6 TNFA/TNFR2-mediated invasion and metastasis in BC TME CXCR1 CCR2 HGF TWIST1 CXCR4 EGFR IL8RB CCL2 STAT3 PMC7031469__F1 Action of metformin in the neuro-glial environment ULK1 CLK1 APP TRPA1 MTOR BDNF IL1B SIRT1 BAX PMC11603874__F4 TNFR2/Mb-TNFA signalosome pathway MUC1 EBP MMP9 EGFR RELB TRAF6 PTEN MTOR TET1 TNC COX2 TAP2 IGF1 CYLD NRP1 CXCR4 CCL20 SHARPIN PFKFB2 BMX CXCL12 TRAF2 STAT3 PMC4871335__F2 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis HEL-S-61p HEL-S-182mP GPT2 GPT PRODH GLS2 AFMID GLDC PAH ASS1 TDO2 PMC4871335__F3 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis SQLE CRAT ACOT4 ELOVL6 DECR1 HMGCR CYP7A1 FADS2 CPT1A CROT ELOVL2 ACLY FASN PMC3820512__F5 Linking Transcriptional Changes over Time in Stimulated Dendritic Cells to Identify Gene Networks Activated during the Innate Immune Response SUMO3 CSNK1D IRAK1 TRAF3 MYD88 STAT5B STAT1 RARA CXCL16 TRAK2 UBE2I MDM2 SP1 PER2 STAT2 CXCL2 CCL4 STAP2 RBX1 EP300 ARL1 AK3 NFKB1 CXCR4 BCL2 hCG_2014051 SYK CR2 NPAS2 PXN FADD SOCS1 TIRAP PER3 STAT3 PMC7384693__F6 Cu-TA’s Biological Targets in MIA PaCa-2 Cells ERBB2 CENPF SP1 DDIT3 SKP2 STAT3 PMC2749448__F1 Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans PDX1 HEL-S-49 PGM2 PCK1 FBP1 ENO1 GLG1 GPD2 NDE1 GPD1 HEL-S-68p PMC3713536__F2 Anticoagulant and cytoprotective actions of the protein C pathway APC ARHA RAC1 PMC7384693__F2 Overlapping Networks and Selection of Network #7 for Further Analysis CBX3 SFN KRT19 PARP2 ERCC1 BTG2 HDAC5 KRT18 GTSE1 AURKB PMC8599883__F1 Zinc in female reproduction NPR2 MOS PDE3A SMAD2 EGFR APC MAPK3 NPPC CDC25B CCNB1 MAPK1 CDC2 GPR3 PMC7384693__F1 Merged Networks (Core of #1 Overlapping Networks) TANK E2F4 TBL1X NTHL1 MYC AHNAK HMOX1 FBXW7 CITED2 DNAJC6 TMSB4X KDR ASB9 WEE1 ATF4 BIRC3 MAML2 IL2 SP1 ABCC2 ATP23 KDM1A GRINA HMGB3 IP6K2 CBX3 DNTT NFATC1 ERG LIF HNF1A BRCA1 DDIT3 DDIT4 ID3 NUDT13 PDGFC BIK ASNS BTG1 TRIM28 CDH10 PCNA GLS CASP4 PMC2880683__F1 Insulin signaling pathway RICTOR PDK2 PTEN MTOR IRS1 PMC3080979__F2 Partial hepatectomy stimulates anandamide production through a pathway involving conjugation of arachidonic acid and ethanolamine by FAAH FOXM1 FAAH PTEN PMC7286322__F4 LncRNA PTTG3P played different roles in different stages of NSCLC CCNA2 NCBP2 FANCD2 LSM6 MYC PRPF40A UBE2T BRCA1 CDC45 RFC3 CHEK2 CDC20 POLE MCM2 CDC6 SMC3 CCNB2 MSH6 SMNDC1 SLK MSH2 ESPL1 CCNE2 USP1 PMC7951058__F4 Molecular pathway and network analysis of proteomics analysis of differentially expressed proteins in LTLT-Ca mammospheres and LTLT-Ca adherent cells SRP54 TIMM44 FARSLA CSTB SCRN1 TOMM7 USP30 TOMM20 PELP1 ARPP19 SCFD1 CARHSP1 CPPED1 PMC11036065__F2 Molecular targeted therapies for cutaneous squamous cell carcinoma: recent developments and clinical implications TEF LRP5 RHEB PMC4815360__F3 Schematic diagram illustrating synthesis of ET peptides and interaction with receptors EDNRA FURIN ECE1 PMC2077852__F3 Dmp1 links the Rb and p53 pathways TBX2 TBX3 MYC MDM2 CCND1 CDK4 BMI1 JUNB DMP1 PMC8814438__F7 Kinsenoside Protects Against Radiation-Induced Liver Fibrosis via Downregulating Connective Tissue Growth Factor Through TGFB1 Signaling SMAD2 TGFB1 PMC3591094__F8 LPA-LPAR1/3 GAi2–mediated activation of p130Cas in cell migration SRC RHO LPA PMC6769793__F4 Metabolic pathway of classic and non-classic androgens HSD11B2 HSD3B1 CYP11A1 HSD3B2 SRD5A2 HSD17B2 POR HSD17B3 CYP17A1 PMC8924072__F6 Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy RPL17 RICTOR RPS4Y1 CYC1 HEL-S-123m HEL-S-87p HEL-S-271 PXN ATP5F1D CLPP HEL-S-162eP PMC9453641__F3 Gamble between oncolytic virus therapy and IFN PDC IRF3 STAT3 PMC3682751__F3 Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity INA HEL-S-11 CP PMC3901118__F3 Overview of the Ras/PKA pathway and relevant regulatory connections involved in the yeast pseudohyphal growth and autophagy responses MUC1 PMC6949817__F8 Schematic presentation of the CBFB/RUNX3-miR10b-TIAM1 pathway TIAM1 RUNX3 CBFB PMC7395702__F1 Signal Transduction Pathway of PD-1 / PD-L1 GRB2 MTOR LAT PMC6468297__F3 MDM2’s switch from a negative to a positive regulator of p53 following DNA damage is dependent on the p53 mRNA RPL11 ATM MDM2 RPL5 PMC4278616__F2 Signaling modulating adherens junctions (AJs) ARHA RHO RAC1 PMC11959147__F1 Illustration of the PI3K (left) and TP53, inside the nucleus, (right) signaling pathways [21, 22] CHEK2 IGF1 ATM MDM2 PTEN ATR DEPTOR BAX PMC9365119__F1 Non-ionotropic NMDAR signaling in neuronal physiology SRC NOS1AP PANX1 TRPV1 PMC6468297__F1 Cell stress-dependent regulation of alternative initiation of p53 mRNA translation ATM MDM2 BAX PMC7710136__F9 Cross-talk between metabolic, inflammatory and muscle growth pathways in dystrophic muscle RICTOR HEL-S-28 TNF ESRRA MEF2C TFAM NR1C1 SIRT1 CYCS CDC42 IFNG PMC7266940__F3 Deeply characterized cellular processes affected by miRNAs in MB SHH SMO MTOR CDK6 HES1 PMC2613033__F1 Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study FADS2 FADS1 ELOVL2 TNLG7C PMC10459190__F2 Molecular mechanisms involved in atherogenic effects of Cd exposure NLRP3 VCAM1 PON1 STAT3 PMC7210388__F8 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 MAML1 SP1 GPR50 ADAM17 HES1 PMC9273281__F1 Senescence-associated secretory phenotype in ovarian cancer dissemination METTL14 CGAS METTL3 DOT1L HMGB2 PMC4250228__F1 Methylation Matters In KRAS Oncogenesis EGFR HBEGF IL6R PMC9298824__F1 Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease NLRP3 CGAS TLR9 IRF3 AIM2 PMC6562901__F1 TGFB Signaling SMAD2 SMAD4 MTOR PMC5702541__F3 MSCs secretome and tumor stemness EGF CXCL1 SOX2 BMP2 MMP9 IL8RB BMP4 CXCR4 MSC FOXP2 CXCL6 S100A4 STAT3 PMC6952548__F7 HCMV miRNA-mediated regulation of TGFB production and signaling during viral latency and reactivation in CD34+ HPCs EGR1 NAB1 CD34 HDAC2 PMC10487916__F3 miRNA–mRNA network based on the target genes of miR-141-3p, miR-150-5p, miR-182-5p, and miR-661 (obtained from the Integrated Breast Cancer Pathway (Wikipathways)) PLK1 MAPK8 MAPK14 ATF1 SMAD4 STAT1 BMPR2 MDM2 RAD50 MSH2 SP1 MAPK7 VEGFA BARD1 DCAKD GADD45A IRS1 BRCA1 FOXO1 RHEB TSC2 TSC1 CDK2 STK11 BCL2 CDC42 HIPK2 EGFR PTEN HIPK1 FOSL2 ZMIZ1 CDK7 DAG1 ATM CCND1 CDK4 BAX ANXA1 TFPI RAC1 MAP3K7IP1 AURKA CASP3 EP300 MAPK6 BMPR1A NFKB1 PIAS1 PMC7374719__F3 Advances in basic research that could lead to the generation of novel therapeutics NF1 LAT2 ERBB2 NRG1 TYK2 STAT3 PMC9355528__F4 Targets and treatments affect oxidative stress in gliomas: An overview of molecular mechanisms IHH ATM SHH MTOR PMC4146646__F11 Schematic summary indicating the mechanism by which Cdt, specifically CdtB, affects the PI-3K signaling pathway and the production of pro-inflammatory cytokines GSK3B TRAF6 MYD88 PMC8257864__F7 Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus ME1 HSD17B12 DUSP5 DPYD MAP4K3 GMPR PPP1R15B PLOD2 PMC8045357__F1 SOCS protein structure SOCS2 SOCS3 IRF7 SOCS4 SOCS7 TRAF6 IRF3 SOCS1 MAL PMC9479325__F5 Integrated analysis of immune parameters, miRNA-mRNA interaction, and immune genes expression in the liver of rainbow trout following infectious hematopoietic necrosis virus infection TANK DHX58 CD209 DDX3X IRF3 MYD88 RIPK2 PMC7210388__F1 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 MAML1 SP1 GPR50 ADAM17 PMC7659026__F2 HMGB1 participates in inflammatory processes HMGB1 CXCR4 CXCL12 PMC6827427__F6 TGF-beta signaling pathway annotated by ceRNA pairs of CDKN2B (p15) E2F4 ROCK1 PITX2 SMAD2 SMURF2 TGFBR1 SMAD6 ARHA SP1 SMURF1 SMAD1 DKFZp781O1323 PMC6779479__F12 Proposed disease model of LMNA-DCM CAMK2D LMNA RYR2 PMC6330352__F3 Cartoon depiction illustrating potential saturated free-fatty acid mechanisms that may underlie arrhythmogenic events INA TLR4 CSA2 IL1B PMC6350191__F6 Mitogen-activated protein kinase signaling pathway CD14 EGF NGF MOS NFIB FLNA EGFR EVL NLK NF1 PAK1 MAX TEF GRB2 ECSIT TRAF2 MEF2C JUN PMC6330352__F2 Cardiac and macrophage inflammatory pathways TLR4 IRAK1 TRAF6 MYD88 IL1B PMC3925034__F1 Schematic depiction of some of the Ca2+ channels, pumps and exchangers involved in Ca2+signalling in mammalian cells HEL-S-11 MCU ORAI1 STIM1 PMC11911377__F1 CGAS-STING signaling pathway and its role in innate immunity TBK1 STAT1 STAT2 CXCL10 IRF3 IFNAR2 TNF IFNAR1 PMC3381865__F6 Proposed model for the role of the IGF-1R/NFKB signaling pathway in regulating the caspase-3 differentiation initiation signal BAD IGF1R BAX PMC11911377__F5 HBV evasion and activation of the cGAS-STING pathway CGAS KPNA2 HAT1 PMC6386986__F5 CRPC development FOXA1 BCL2 SEMA3C PMC6178121__F2 Pathway analysis shows apolipoprotein E along with its respective interactions in Parkinson’s disease and schizophrenia pathway HEL-S-62p SNCA SLC1A1 FLNA SMAD2 NEF3 LRP8 PTEN PPIF SLC25A6 CASP3 VLDLR A2M PSEN1 CYC1 LDLR APP BCL2 DCTN1 SRPK2 PMC9322175__F2 Critical Roles of NFKB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis NFKB1 LTB RELB PMC2423668__F1 Two branches of TLR downstream signaling TRAF6 IRF3 MYD88 PMC6745179__F7 CD28 KO reverses lung blast injury by the PI3K/Akt/FoxO1 signaling pathway IL16 CD2 CD163 CD44 IL1B BAX PMC10451380__F1 Scheme of the NRF2 signaling pathway MAF KEAP1 SFN RBX1 PMC8533980__F5 CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer TBK1 CGAS IRF3 PMC374303__F8 The multiple mechanisms by which HSV-1 blocks cellular IFN-based defense systems STAT1 PML EIF2A SP100 PMC5533325__F5 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) CD14 CTSK TLR9 TRAF6 IRAK4 IRF3 RAC1 TLR3 TLR4 LBP CD40 FADD TIRAP PMC7086357__F8 Proposed model depicting the molecular mechanism by which Serelaxin activates Notch signaling pathway to inhibit TGFBeta-induced SMAD2/3 phosphorylation to restore the RXFP1 expression via histone modifications SMAD2 TGFB1 PMC6365411__F1 A) Experimental design depicting the sampling time points represented as days post hatching (dph) during the different gonad developmental stages covered by the study VIT ALDH1A3 RBP4 CRABP1 ALDH1A2 PMC9265711__F1 LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo LIMK2 LIMK1 RHO CDC42 PMC5321852__F4 Hypothetical TRPC4- / TRPC6-mediated signaling pathway downstream of TGFB1 in InMyoFib cells TRPC4 TRPC6 CDH2 COL1A1 PMC9619486__F1 In silico investigation of the role of vitamins in cancer therapy through inhibition of MCM7 oncoprotein MCM3 MCM5 MCM6 MCM2 MCM7 CDC45 PMC5533325__F6 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) PIM1 EPO IL6 IFNG PMC5891947__F1 Potential LMTK2-related neurodegenerative mechanisms in Alzheimer’s disease SMAD2 GSK3B LMTK2 PMC10311566__F1 Recent progress of peptide regulators for the Wnt/Beta-catenin signaling pathway APC LRP5 SMAD4 LRP6 PTH GPR49 LGR6 PMC8310855__F3 Cannabinoids in the landscape of cancer BAD GPR55 NUPR1 TRPV2 ATF4 ATF2 TRIB3 ARHA TRPV1 TRPM8 PMC8507398__F9 Molecular biology of autoinflammatory diseases TRADD IRAK1 TRAF6 IRAK4 MYD88 RIPK2 MAP3K7IP1 NOD2 RIPK1 NOD1 TRAF5 CYLD SHARPIN TRAF2 OTULIN TIRAP TAB3 PMC8564564__F4 Unfolding the role of autophagy in the cancer metabolism UVRAG MTOR PMC9687868__F3 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis EGF NF2 EGFR HIF1A MTOR PMC9687868__F2 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis EGFR PMC8195994__F7 Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition APLN TNF IRS1 PMC9585282__F5 Transcriptomic and metabolic analyses reveal the potential mechanism of increasing steroidal alkaloids in Fritillaria hupehensis through intercropping with Magnolia officinalis ERF PMC3187934__F2 Phosphorylation pathways adapted from KEGG (50)(51) TSC2 TSC1 IGF1R GRB2 MTOR IRS1 PMC4111999__F1 Schematic showing the possible integration of emerging, mass spectrometry-based technologies into the untargeted metabolomic pipeline PMC2491704__F3 Recycling pathway of acetylcholine (ACh) synthesis, release, action and breakdown at a cholinergic nerve terminal ChAT ACHE BCHE PMC6987193__F7 Schematic model based on our results showing the role of E2 in DCIS metastasis to IDC MMP3 IRAK1 MYD88 IL1B GSDMD PMC9289374__F1 Gene expression profile of epithelial–mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD SNAI1 TWIST1 SMAD2 ZEB2 MMP9 SMAD4 CDH2 PMC7287184__F5 Kyoto Encyclopedia of Genes and Genomes (KEGG)-enriched pathways and related genes CCNA2 PLK1 SFN TTK SMAD4 SERPINB5 BCL2L1 PKMYT1 CDK7 CHEK2 PERP RRM2 CCND1 CDC2 PTTG1 STEAP3 CDC45 CDC20 CDC6 CDK2 CCNB2 SESN1 TNFRSF10B HEL-S-93 GTSE1 PMC4031942__F13 Anti-inflammatory mechanism of C3G is associated with upregulation of the LXRAlpha-ABCG1 pathway which results in disrupting lipid rafts by depleting cholesterol, thereby suppressing the TLR4-mediated NFKB and IRF3 signaling pathways induced by LPS TLR4 ABCG1 IRF3 MYD88 PMC3294670__F7 Mechanisms of control of Listeria entry by the type IA PI 3-kinase signaling pathway DAPP1 RAC1 RAB5C MTOR ARF6 SWAP70 ARAP2 PMC8398409__F6 Reactive Oxygen Species in Host Plant Are Required for an Early Defense Response against Attack of Stagonospora nodorum Berk. Necrotrophic Effectors SnTox TOX3 PRX PMC11746911__F1 Canonical and non-canonical Smad signaling pathways induced by TGFB SMAD4 RAC1 CDC42 PMC4657124__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC9596750__F1 Targeting the inflammasome in Parkinson’s disease NLRP3 APC TXNIP PMC7919800__F1 Insulin-like growth factor (IGF)/IGF-1R signaling pathway in the development of liver disease IGF1R IGF1 IGF2 PMC11746911__F3 Wnt/Beta-catenin and NFKB signaling pathways TLR4 APC LRP5 LRP6 MYD88 SIRT1 PMC7589301__F1 The possible molecular mechanism of amantadine’s antidepressant effects at the level of dopaminergic and glutamatergic transmission DDC BDNF PMC11746911__F2 VEGF signaling pathway MTOR CSF1 VAV2 PMC4859887__F2 RTKs mediate DDR through canonical AKT and RAS pathways BAD ATM TOPBP1 PARP1 ATR BRCA1 PMC9266551__F3 Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2 TBK1 LGALS3BP TRAF3 TRAF6 IRF3 TNF PMC2952191__F2 mTOR signaling pathway TSC2 TSC1 ELF3 PTEN EIF4E MTOR DEPTOR EIF4B RHEB PMC4859887__F3 Some RTKs regulate DDR through specific canonical pathways CDK2 EGFR ERCC1 CDC2 PCNA PMC11699683__F5 Signaling pathways of UA-mediated antioxidative stress and anti-neuroinflammation in neurodegenerative diseases NGF KEAP1 APC AXIN1 LRP5 BDNF STAT3 PMC5031174__F7 Diagram showing the regulation of dopaminergic neuronal differentiation of human neural stem cells (hNSCs) PTEN MTOR IRS1 PMC6233178__F1 Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury NLRP3 ATF4 EIF2A ATF5 IL1B ROS1 PMC8634653__F2 Integrins in Gastrointestinal Cancer Metastasis EGF PLG SMAD2 EGFR GRB2 MTOR CDH17 AKT3 PMC10299014__F1 IL-17RA/RC signalling pathways (Figure adapted from Monin and Gaffen , and from Chung ) EBP TRAF6 TRAF2 IL17RC PMC11603363__F2 Pyroptosis and the role of immune and non-immune cells in asthma STAT1 NLRP3 TLR4 NLRC4 NLRP1 CARD8 AIM2 GSDMD PMC8634653__F1 Integrins in Gastrointestinal Cancer Metastasis SOX2 GSK3B BMI1 RHO RAC1 HIF1A CDC42 PMC11603363__F1 Pyroptosis pathways GZMA GSDMC GSDMB GSDMD PMC7672621__F9 Schematic regulatory pathway of linagliptin in OSI-906-induced hepatic steatosis IGF1R IGF1 NNMT PMC8417734__F2 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases ZNRF3 RNF43 ATF2 APC LRP5 LRP6 ARHA GPR49 FBXW7 ROR1 CDK14 ROR2 JUN HEL-S-29 CDC42 PMC8417734__F4 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases SFRP4 BMP1 MMP9 WNT1 GSK3B FZD4 RHO RAC1 NFATC3 SFRP5 WNT3 LEF1 WNT3A MMP2 CRP FZD7 BCL2 SFRP1 CAD AXIN2 BAX PMC9442994__F9 MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/Beta-catenin signaling pathway MICAL2 CDC42 PMC3004842__F2 Flux-sum intensity in Z CS CIT TNLG7C MAL PMC12052642__F1 Schematic view of principal anti-tumor effects of resveratrol on different cancer-related mechanisms CCND1 STAT3 BAX PMC12052642__F3 PI3K signaling pathway in cancer onset and progression BAD MDM2 PTEN AKT3 BAX PMC2213056__F1 AID-initiated SHM pathways MSH6 MSH2 POLN UNG PMC12052642__F2 Major signaling pathways regulated by resveratrol KEAP1 APC LRP5 LRP6 PTEN STAT3 PMC11699683__F2 UA in antioxidative stress and anti-inflammation NLRP3 TLR4 SLC2A9 PMC6370283__F1 Exogenous pathway of lipid metabolism.apo B-48 = apolipoprotein B-48, apo C-II = apolipoprotein C-II, TG = triglyceride, apo E = apolipoprotein E, LPL = lipoprotein lipase LPL TG APOE PMC6437734__F10 VPA impacts the B cell differentiation into plasma cells and in the isotype switch and maturation affinity of immunoglobulins AID CD40 CD69 PMC6437734__F12 VPA promotes the generation of Treg cells ETS2 FOXP3 PMC6097514__F1 Targetable cell survival mechanisms.Notes: Stimulation of the BCR and its co-receptor CD19 results in downstream signaling via the PI3K/AKT/mTOR pathway BTK BCR LYN SYK PLCG2 MTOR CD19 PMC3431627__F7 Mechanisms of acquired-resistance to vemurafenib IGF1R BRAF NRAS FGFR3 PMC3825725__F1 Janus face of cyclophosphamide STAT2 IRF7 UNC93B1 CXCL10 IFITM2 DDB2 CCND3 CD69 OAS1 CDKN1A MARCO TYK2 SESN2 UBE2L6 BAX PMC12098830__F6 Other immune signaling pathways in CVDs TBK1 IRF7 APC LRP5 LRP6 IRF3 LATS1 LATS2 PMC12098830__F8 Integration of key signaling pathway in CVDs with immune response EGF KEAP1 HEL-S-11 EGFR PMC3880546__F1 Physiological regulation of the mTOR pathway TSC2 TSC1 PTEN EIF4E STRADA RHEB PMC3189939__F3 CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma PRKCA SFRP4 CAMK2D KREMEN1 ARHA RYK VANGL1 CELSR2 CDC42 PMC12098830__F4 Innate Immune Signaling pathway in CVDs TBK1 HEL-S-62p CGAS C4B_2 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 RIPK2 NOD2 ZBP1 GSDMD NLRP3 TLR8 TLR7 TLR4 NOD1 C7 C1S AIM2 IFI16 TLR5 IRF7 NLRP12 DDX41 IRF3 TLR1 MAP3K7IP1 TLR3 C6 MAVS AKT3 TAB3 PMC9080202__F1 Sestrin2 in cancer: a foe or a friend? TSC2 ULK1 PMC5999604__F1 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma BOC SUFU GSK3B SMO PMC5999604__F4 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma GSK3B CNOT1 RPS3 PMC5999604__F3 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma NUSAP1 DHH BOC PTCH2 IHH KIF7 RAB23 LMNA ITGB1 AURKA FOXC1 SUFU PTCH1 GLI3 SHH SMO OSR1 TUG1 SKI B4GALT1 PMC5999604__F2 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma DHH BOC PTCH2 IHH KIF7 SUFU PTCH1 GLI3 GSK3B SHH SMO PMC8616057__F7 MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells BRAF GRB2 RAC1 PAX8 PMC4733614__F4 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies APC OTC CD80 IFNG PMC4733614__F3 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies BCR FH GC CD34 STAT3 POLI PMC4733614__F2 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies APC CD80 IFNG PMC5328971__F3 Gamma-aminobutyric acid signaling pathway PLCL1 PLCL2 HTR4 GABBR2 SLC12A2 ATF4 GABRE GABRB1 GABRA2 HTR2A BDNF GABRA6 GABARAP PMC4733614__F1 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies BCR NFATC1 IRF9 SYK PMC5286794__F1 Regulation of key cancer stem cell signaling pathways by epigenetic mechanisms APC LRP5 LRP6 STRAP DKK1 EZH2 HDAC1 SUZ12 EED HES1 PMC6790052__F1 Ciona robusta cardiopharyngeal gene regulatory network and tunicate phylogeny ST14 ST13 ST18 PMC10991369__F6 Comparative transcriptome analysis of Trichoderma reesei reveals different gene regulatory networks induced by synthetic mixtures of glucose and Beta-disaccharide SVIP SEC62 PMC3880546__F2 Pathological regulation of the mTOR pathway in neurological disease TSC2 TSC1 PTEN EIF4E STRADA RHEB PMC3059752__F3 Knowledge-based pathway analysis (Genomatix BiblioSphere Software) indicating the network of high BMI-associated genes MAF EFS ANTXR2 INSIG1 SFN PDZRN3 RHOU SOX4 PMC5404975__F1 Overview of the core components of canonical Hippo signaling LATS1 LATS2 PMC8307462__F1 NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities PSAT1 PSPH PHGDH PMC5766603__F5 Phenylephrine synthesis SLA HP NRTN ADM PMC5318160__F5 Glucocorticoid-driven network links many of the top-ranked PLSR genes TXK DAAM2 MAPK8 MAPK14 FKBP5 CLEC4E MTOR DDIT4 CEBPB GC ZBTB16 MAPK1 NR1D2 FLT3 PER2 PER1 PMC9136176__F3 Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways EGFR STAT3 PMC3544293__F2 MTOR signaling pathway TSC2 RICTOR TSC1 EGFR STK11 PTEN MTOR IRS1 RHEB PMC6798062__F1 RAS pathway in cancer TIAM1 NF1 SIRT2 BAD FOS MYC RHO MTOR JUN WHR1 PMC7084352__F4 Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings PRMT1 HEL-S-277 PRMT2 ARG2 NOS2 ARG1 PMC7676208__F7 Potential mechanisms of inflammation by COLEC12 mediated through TLR4 in osteosarcoma HEL-S-62p IL18 TLR4 MPO COLEC12 PMC7084352__F3 Alterations in expression of L-arginine/NO pathway enzymes in inflamed and quiescent tissue from patients with Crohn’s disease as compared to normal small bowel tissue derived from patients with ulcerative colitis PRMT1 HEL-S-277 PRMT2 NOS2 ARG1 PMC7084352__F1 Simplified scheme of L-arginine/NO pathway PRMT1 HEL-S-277 PRMT2 ARG2 OTC NOS2 ARG1 ASL PMC7854359__F4 Conservative route to genome compaction in a miniature annelid TSC2 TSC1 MNT MAX MYCL MYC LATS1 PTEN TNF MTOR LATS2 RHEB PMC3666883__F11 Sonic hedgehog-Dependent Induction of MicroRNA 31 and MicroRNA 150 Regulates Mycobacterium bovis BCG-Driven Toll-Like Receptor 2 Signaling SUFU PTCH1 TRAF1 TRAF3 SHH SMO MYD88 TRAF2 PMC6126377__F2 Schematic diagram illustrates how tilorone and hypoxia may share common mechanisms in the mediation of the preconditioning response TBK1 STAT1 ISG15 IFIT3 CGAS TREX1 IRF3 IFIT1 PMC5054337__F3 Simplified central carbon and amino acid metabolic network CIT MAL PMC6126377__F1 Oxygen sensing HIF prolyl hydroxylases modulate transcriptional and metabolic adaptive responses EPO ATF4 TRIB3 PDK4 PMC10971231__F1 Interplay of signaling pathways: cellular dynamics within the pancreatic ductal adenocarcinoma microenvironment NGF MMP2 MMP9 IL33 IL6 CCL2 PMC10971231__F2 Pivotal role of the NGF/TrkA signaling pathway in PDAC NGF ASIC3 GDNF BDNF TRPV1 PMC8705083__F1 Eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles EIF5A DOHH DHPS PMC5974435__F3 MAPK signaling to the translational machinery TSC2 EEF2K BRAF APP RPS6 DEPTOR EIF4B ARAF PMC11545879__F4 Mechanisms of Tregs in immune checkpoint blockade therapy SMAD2 APC ZAP70 GRB2 TRAF6 CD80 TIGIT GIT2 CD226 FOXP3 BATF PMC2809500__F4 Proteins upregulated during time course analysis in lung or bronchoalveolar lavage fluid (BAL) following intra tracheal instillation of 20 μg carbon nanopaticles (CNP) FGA EDN1 IL18 CRP VWF HEL-S-92n CSF1 CCL1 THPO PMC11019719__F2 Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review EGR1 ARC BDNF SIRT1 STAT3 PMC8037238__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAc Cycling OGA OGT GNPNAT1 PMC7539786__F6 Scheme showing the activation of the STING pathway by cytosolic DNA and regulation by metformin TBK1 CGAS IRF3 PMC5974435__F2 MTOR and MAPK pathways affect the translatome by modulating the expression of specific subsets of mRNAs ELF2 EEF2K LARP1 ATF4 EEF2 TIA1 CCND3 MRE11A EIF4B BRCA1 SKP2 PMC5974435__F1 MTOR signaling to the translational machinery EEF2K SLC38A9 EEF2 TBC1D7 PTEN DEPTOR RHEB TSC2 NF1 TSC1 GRB2 MAF1 RPS6 EIF4B SGK1 PMC6605043__F1 Probable mechanisms of the effects produced by lncRNAs on TBI.Notes: There are several lncRNAs that have been reported to play different roles in the process of TBI PMC1197416__F6 Several signaling pathways converge to drive actin polarization SIM1 CDC42 SIM2 PMC11124330__F17 This study TLR4 CXCL5 S100A8 CXCL3 S100A9 MYD88 PMC11201820__F2 Interaction between activated ECs and pericytes/vascular smooth-muscle cells (vSMCs) and their targeted inhibitors in red EGF EGFR VEGFA ENG PTEN MTOR PMC11201820__F1 Relevant pathways and their targeted inhibitors (in red) for the EC ANGPT1 EGF EGFR VEGFA ENG PTEN MTOR PMC11668352__F7 Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease NLRP3 ATF4 TXNIP PMC5524151__F1 BDNF signaling is a balance between proBDNF/p75NTR and BDNF in glial cells or inhibit phosphorylation of FL-TrkB thereby preventing stimulation of survival, growth, and neuroplasticity FLT1 PLG BDNF PMC11545879__F2 Various genes expressed by Tregs and their surface molecules CXCL10 CCR4 TIGIT LAG3 MTOR CCR8 CCL1 FOXP3 CXCR3 CCL17 CXCL9 CD80 CCL22 PMC5545931__F6 PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer IGF1R GRB2 PMC6270946__F3A Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth FactorB1 USE1 OS9 ATF4 SVIP SKP1 RBX1 PMC6358904__F4 Graphical model of IL-1B activation of signaling pathways leading to acquisition of resistance to cisplatin in breast cancer cells ATM TP63 EGFR IL1B PMC7532081__F6 Diagram illustrates the hypothesis that TP53INP2 modulates cell migration, invasion, and EMT via the GSK-3B/Beta-catenin/Snail1 pathway in bladder cancer.Abbreviation: EMT, epithelial-to-mesenchymal transition TP53INP2 GSK3B PMC4762928__F1 Glucose and glutamine metabolism in cancer cells HEL-S-133P GLS PMC8671998__F3 Immunogenic ferroptosis and where to find it? HMGB1 IL18 TLR4 TLR9 IL1B PMC8699888__F1 Cellular Senescence in Adrenocortical Biology and Its Disorders CDK2 CDK4 CDK6 PMC5393957__F2 Molecular genetics of osteosarcoma GSK3B PTEN EIF4E MTOR RHEB TSC2 NF1 TSC1 TFEB NF2 GRB2 ACLY FASN PMC9023794__F2 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection RIPK1 TRADD TRAF5 RIPK3 TRAF2 FADD ZBP1 MLKL PMC5370073__F1 Impact of CTLA-4 Ig versus anti-CD28 domain Abs on alloreactive T cell responses APC CD80 TNF PMC11064142__F10 TLR signalling leads to apoptosis in tumour cells TRADD STAT2 IRAK1 IRF9 TRAF3 TRAF6 IRAK4 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 TLR4 TYK2 JAK1 MCL1 FADD TIRAP BAX PMC8181424__F1 Exercise Factors Released by the Liver, Muscle, and Bones Have Promising Therapeutic Potential for Stroke HDAC3 HDAC2 GPR158 BDNF SIRT1 PMC3909253__F9 Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism TLR4 TRAF6 MYD88 TLR1 TNF TIRAP MAL PMC12028518__F5 Expression of the GNPDA1 signaling pathway in breast cancer (MetaCore) ChAT NGF NR3A2 ATM BRCA2 BARD1 RAD50 RAD51 MSH2 ATR CDC42 PMC11940432__F2 Intracellular signaling pathways of LGR4 ZNRF3 PITX2 APC LRP5 LRP6 PMC3891116__F2 Essential cell signaling pathways for prostate cancer (PCa) development and crosstalks between themThe interaction of circulating androgens (T/DHT) with AR is critical for PCa growth EGF IGF1 GSTT2 EGFR PTEN DDT TRPV3 HIF1A IL6R FOXO1 STAT3 PMC8126603__F2 Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 TBK1 STAT1 TLR7 STAT2 IRF7 RAE1 IRF9 NUP98 IRF3 MYD88 TLR3 MAVS PMC12219279__F5 Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway IGF1R IGF1 IGFBP5 IRS1 PMC9608511__F4 Current insights into the regulation of programmed cell death by TP53 mutation in cancer GPX4 SLC7A11 ADA HEL-75 SLC3A2 PMC9608511__F7 Current insights into the regulation of programmed cell death by TP53 mutation in cancer BAD BAX PMC4631973__F1 PI3K/PTEN/Akt/mTOR-cascade (Modified according to Cingarlini et al and McCubrey et al) TSC2 TSC1 IGF1 PTEN DEPTOR IRS1 RHEB MLST8 PMC9299105__F2 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 C4B_2 C1S C4A PMC4747727__F3 Proteomics analysis of exosomes from EBV-driven LCLs compared with exosomes from CD40L-stimulated B cells shows “immune system process” as the most represented pathway, and an enrichment in “integrin-mediated signaling” and “cell adhesion” terms CD9 MARCKS IFITM2 CD48 SPN FYN OAS2 FCER2 F2 CD2 SRC KRT13 HEL-S-70p ANKH c-fgr SCIMP TNIK RPN2 BTLA CYBB FLOT2 HLA-A PTPRC CANX LCK LSR KRT9 ACADM PLXNB2 PMC3154047__F1 Activation of mammalian target of rapamycin complex 1 (mTORC1) TSC2 TSC1 MTOR RHEB MLST8 PMC8868482__F1 Involvement of Inflammasome Components in Kidney Disease NLRP3 TXNIP XBP1 MAVS PMC9299105__F4 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 NLRP3 HMGB1 IL18 IL16 TLR4 IRAK1 TRAF6 IL1R1 IRAK4 MYD88 PMC4230700__F3 Disseminated cancer cell dormancy: an awakening field SMAD2 TGFBR1 EGFR TGFBR2 BMP7 CCND3 BMP4 BMPR2 CDK4 TGFBR3 AXL SMAD1 TGFB1 PMC9023794__F1 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection BAD BIK EIF2A BMF FADD LAT HRK BAX PMC6823288__F6 Significant KEGG pathways enrichment of DEGs AOX1 EDNRA VCAN ATF3 C4BPA DCC TTN DDIT4 INHBA ICOS SELE CCS PMC7304108__F8 Proposed model by which hsa_circRNA_102610 promotes growth and transforming growth factorB1-induced epithelial-mesenchymal transition of intestinal epithelial cells by sponging hsa-miR-130a-3p SMAD4 CCND1 CDH2 PMC3696739__F3 Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development MMP2 BMPR1A MSX2 PMC11735109__F11 Schematic representation showing a possible mechanism of YAP1-driven induction of immunosuppression in UCB mediated by the IL-6/STAT3 pathway YAP1 IL8RB STAT3 PMC1176393__F2 Regulatory network of stress responses to drought, salt, and cold: specificity and cross-talk SOS2 SOS1 CBL PMC9561407__F3 Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns GPX4 LPCAT3 FACL4 SLC7A11 SLC3A2 GABPB1 PMC6311104__F2 Steps in miRNA biogenesis AGO1 AGO2 DGCR8 AGO4 DROSHA PMC4180403__F1 Therapeutic Considerations in Treating HER2-Positive Metastatic Breast Cancer BRAF MTOR PMC9629604__F1 IFN activation of the JAK-STAT signaling pathway STAT1 KL STAT2 IFNG PMC11200741__F3 Outline of the Hippo signalling pathway MYC LATS1 LATS2 PMC10896604__F4 Metabolic pathways involved in rectal cancer radioresistance, including significantly upregulated (marked in red) and downregulated (marked in green) abundances of proteins and metabolites in poor responders tumor tissues FH SHMT1 HEL-S-51e HEL-S-133P PHGDH HK2 HEL-S-162eP GLS PMC11200741__F1 Canonical pathway (WNT/Beta-catenin pathway) LEF1 APC GSK3B LRP5 LRP6 PMC3717794__F2 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway TIGAR GLS2 BAX PMC3717794__F1 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway TSC2 TSC1 PTEN RHEB PMC9141140__F4 Rare Variant Analysis and Molecular Dynamics Simulation in Alzheimer’s Disease Identifies Exonic Variants in FLG BACE1 FLG APP PMC11580016__F2 The sources of AHR ligands KYNU AHR KMO PMC11580016__F1 AHR signaling AHRR AHR CYP1B1 SRC PMC5674068__F10 The breast tumor vs mammary gland serial-omics experiment RICTOR PC ACACA GRB2 MTOR TG HEL-S-104 FASN PMC3136711__F2 Qu on cell cycle CDK2 CDK4 CDK6 PMC2096753__F1 Summary of purinergic pathways involved in microglial response NGF PLG IL1B PMC12102305__F9 Graphical abstract shows the unique characteristics of neuron damage in the SN of PD mice due to oligodendrocyte and astrocyte crosstalk GPX4 FGFR1 SLC7A11 ATP6V0C FGFR3 COXFA4 FGFR2 FGF9 PMC7347012__F6 Development of ocular surface ectodermal cell lineages from human induced pluripotent stem cells DKK1 BMP4 PMC4401222__F1 TLR4 signaling pathway and its relation with atherosclerosis TLR4 IRF3 MYD88 TNLG7C PMC5961736__F2 Illustration of JAK/STAT signaling pathway that inspires effective therapeutic targets in lymphoma MYC CCND1 SRC BCL2 MTOR PMC7185085__F1 Exogenous LPS directly leads to an increase in the production of white adhesion molecules and other cytokines such as ICAM-1 and vWF ERBB4 TLR4 ERBB2 VWF ARHA IL1B PMC5961736__F1 Illustration of cross-communication network of BCR, PI3K, and NFKB signaling pathways that harbor effective therapeutic targets in lymphoma BTK CARD11 BCL10 BCR RELA RELB CD40 SYK PTEN MYD88 MTOR PMC5961736__F4 PD-1/PD-Ls signaling pathway that acts as effective therapeutic targets in lymphoma APC ZAP70 MTOR PMC3167192__F1 Molecular basics of tumor angiogenesis EPO NOS2 EPHB4 PMC5961736__F3 Apoptosis signaling pathway that contains effective therapeutic targets in lymphoma TRADD ATM MYC MDM2 BCL2 TNF ATR FADD BAX PMC3639415__F8 The regulation and function of MYC in the androgen signaling pathway in molecular apocrine breast cancers MAX FOXA1 MYC TCF7L2 PMC4571974__F9 TRAF6 regulation by arginine methylation PRMT1 JMJD6 TRAF6 IRAK3 PMC6502998__F2 Marè et al CS FH CAD PMC6156235__F6 A schematic illustration of how dipalmitoylphosphatidic acid (DPPA) might inhibit angiogenesis in breast cancer HGF Nbla10317 PMC8389681__F4 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context CTH NAMPT MVK HRAS C3AR1 CREB3 RAP2A SUZ12 RNF139 UBC MVD NANS SEC31A CYLD BSCL2 HEL-75 CDC27 USP47 HSCB HEL-S-51e VCP HEL-S-36 POLI PMC8389681__F6 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context B3GAT3 SQLE CTSL TNIK HEL-S-28 USP20 HERC3 SYVN1 CYP51A1 AMFR STUB1 DHCR7 CYLD PJA2 PTPN5 ITCH PMC10222229__F2 Roles of protein phosphatases in liver regeneration PFKFB2 STAT3 PMC4524427__F1 Insulin signaling network that links nutrition to growth and size TSC2 TSC1 EIF4E RHEB PMC4105198__F8 B3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition TBK1 EGFR RALB PMC8017223__F1 IL-23 receptor polymorphism associated disorders STAT4 TYK2 STAT3 PMC3610211__F1 TSC/mTORC1 signaling pathway at the neuronal synapse NF1 TSC2 FBXO45 TSC1 PTEN EIF4E MTOR RHEB PMC8861264__F8 Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy CGAS TMEM43 ATM GDF15 VCAN LMNA TGFB1 TGFBI PMC5994257__F11 Schema of signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production NLRP3 TLR4 IL1R1 IL1B PMC7530326__F1 TGFB signaling pathway GDF6 BAMBI GDF5 BMP6 gdf7 NODAL BMP2 SMAD2 BMP15 SMAD6 TGFBR2 SMAD4 BMP7 GDF1 BMP4 BMPR2 ACVR2B AMH BMP10 BMP5 GDF11 SMAD1 GDF3 DKFZp781O1323 PMC7530326__F3 Dysregulation of BMP-ALK1-Smad4 signaling in HHTs VEGFA SMAD4 PTEN PMC7530326__F2 Dysregulation of TGFB/BMP signaling in CCM CD14 BMP6 TLR4 KLF4 CD44 SMAD4 KLF2 PMC4304911__F3 Regulation of protein synthesis through the mTOR signaling pathway by amino acids and insulin TSC2 TSC1 EIF4E MTOR IRS1 PMC9149051__F2 Figure 2:. Adaptive response programs in tumor cells and in the tumor ecosystem WEE1 ATM CDK2 EGFR RAD51 CDC2 MTOR ATR H2AX IRS1 BRCA1 PMC12116488__F2 Testosterone-AR signaling pathway in HCC immunotherapy EZH2 IFNG USP18 FOXP3 PMC11276060__F3 LncRNAs in autophagy, apoptosis response, and inflammation of cells to bacterial invasion NLRP3 LTA STAT4 MYD88 EZH2 MTOR PMC12116488__F1 Molecular mechanisms of estrogen signaling in hepatocellular carcinoma (HCC) progression and immune modulation SOCS3 STAT3 PMC11889322__F3 Diagram depicts the Aryl hydrocarbon receptor (AhR) signaling pathway, starting with the cytoplasmic retention of inactive AhR in a complex with heat shock protein 90 (HSP90), X-associated protein 2 (XAP2), and p23 AHRR AHR CYP1B1 CYP1A1 PAH PMC7188081__F1 Advanced Glycation End Products: Building on the Concept of the “Common Soil” in Metabolic Disease GSK3B IRS1 PMC8228386__F2 FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde? STAT2 FGF19 FGFR4 STAT3 PMC8184591__F1 Network of Paf1C Functions INO80 MSL2 MSL1 POLL PAF1 POLI PMC4738716__F5 Network of TREM1 and PTGS2 (COX-2) upstream regulators and their target molecules, evaluated in the peripheral blood cells of breast cancer patients compared with healthy donors (Ingenuity Pathway Analysis) CXCL1 TREM1 EGR2 ITGA6 FOS AREG CXCR4 PTGS2 NBN IL8RB CXCL14 CEBPB PMC9140735__F8 STIM1–Orai1 Interaction Exacerbates LPS-Induced Inflammation and Endoplasmic Reticulum Stress in Bovine Hepatocytes through Store-Operated Calcium Entry ORAI1 STIM1 PMC2841057__F1 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension ATR IRS1 PMC2841057__F4 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension ATR IRS1 PMC6314084__F6 Evidence of active A MAF GAR1 TNLG7C PMC4890635__F3 SOX9 is downstream effector of ERG and AR in TMPRSS2:ERG fusion-positive PCa FOXA1 ERG SOX9 PMC7362612__F1 Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target TBK1 TRADD RIPK3 TNF PELI1 OPTN RIPK1 CYLD TRAF1 SHARPIN TRAF2 OTULIN TBKBP1 CASP8 FADD TAB3 PMC3770140__F2 PHLPP suppresses the PI3K/Akt signalling pathway PTEN MTOR PMC3382482__F1 GFPT1-mediated MTOR signaling pathway affected by glucose and fructose in a pTr cell line TSC2 RPS6 EIF4EBP1 MTOR GFPT1 PMC8642801__F1 DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment DLL4 MYC NRARP PMC8657577__F1 Genetic Variants of the NFKB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease TNFRSF1B RELA TNFRSF1A REL TNF CARD14 PMC3942504__F1 Molecular mechanisms of Bcl-6 expression in T cells STAT1 PHLPP2 STAT4 CXCR5 PTEN FOXO1 ICOS IFNG STAT3 PMC9533579__F3 Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review MMP3 WNT5B PMC9476775__F5 Brusatol: A potential anti-tumor quassinoid from Brucea javanica SQSTM1 CDH2 MTOR BAX PMC1449730__F2 F igure 2.— F2 F3 C6 PMC5700013__F2 PCSK9 in neuronal apoptosis CASP3 PCSK9 CASP9 BCL2 BAX PMC8745764__F4 COVID-19: Immunohistochemical Analysis of TGFB Signaling Pathways in Pulmonary Fibrosis SMAD2 ACE2 PMC8744613__F6 Energy Sensor AMPKA1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory ULK1 HIF1A FOXO1 PMC11582033__F8 Druggable targets and therapeutic strategies for melanoma treatment BRAF NRAS CTLA4 MTOR PMC11582033__F7 Combination therapy of melanoma using BRAF, MEK, and immune checkpoint inhibitors TH NRAS CD80 CTLA4 PMC6206931__F6 Overview of lipid remodeling in yeast during acid adaptation, where heavy arrows indicate enhanced biosynthesis GIG8 PSD2 PAH PMC11582033__F5 MAPK/ERK signaling pathway and its role in cancer development DUSP4 BRAF CCND1 SRC CDK4 PTEN CDKN2A AKT3 STAT3 PMC9306810__F3 ODORANT1 targets multiple metabolic networks in petunia flowers CS CAD PMC11582033__F2 BRAF/MAPK pathway TSC2 TSC1 HGF GRB2 MTOR FOXO1 PMC8141029__F1 mTORC1 stimulates SAM synthesis TSC2 MAX IMPACT INS PMC11582033__F1 RTK/RAF/MAPK signaling in melanoma and its effects on immune cell activity BRAF CD80 PMC5380548__F2 Wnt signaling and cellular metabolism in osteoblasts ATF4 EIF2A LRP5 LRP6 GLS PMC5524462__F2 PD-1 is also expressed on T-cells following TCR engagement and activation APC MTOR BATF PMC8502826__F10 Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers NOX3 ABCC3 GCKR ANGPTL3 NNMT CEBPA SAA1 CCN4 RCHY1 ORM1 UNC93A PC HPD RBP4 ANGPTL8 CLEC1B HGFAC PMC3616052__F5 Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content IPP PMC11524886__F3 Potential mechanisms by which exercise-mediated release of irisin exerts antidepressant effects TLR4 UCP1 MYD88 BDNF FNDC5 UCP2 PMC4637890__F6 IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway MTOR ATG14 STAT3 PMC11395143__F2 Nrg1/ErbB signaling ERBB2 ERBB3 GRB2 NRG1 MTOR PMC8550604__F1 Factor Xa beyond coagulation TFPI GLA TF PMC7518592__F5 Global gene expression profile under low-temperature conditions in the brain of the grass carp (Ctenopharyngodon idellus) SQLE MVD DHCR7 EBP FDFT1 MVK HMGCS1 HMGCR ACAT2 PMC10915378__F6 Neurodevelopmental and thalamocortical processes involved in epistasis driving spike‐and‐wave discharge (SWD) phenotypes in mice PAK1 DUT TUBGCP4 PMC11045263__F1 Mechanisms underlying enhanced immunotherapy efficacy through exercise SQLE CXCR3 CXCL9 IL15RA CXCL11 PMC4773745__F1 Inhibition of components of the Shh Pathway in cancer SOX2 SUFU PTCH1 MYC SHH PMC9312812__F5 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer TSC2 TTI1 FLCN TSC1 FNIP2 FNIP1 MTOR DEPTOR RHEB MLST8 PMC7934813__F2 Central role of ACE 2 in SARS-CoV-2 infection and COVID-19 severity ATR ACE2 TMPRSS2 PMC4497429__F1 The PI3K/Akt/mTOR signaling pathway and CSC biology RICTOR EPCAM ABCG2 PMC9312812__F1 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer TSC2 FLCN TSC1 FNIP2 FNIP1 RHEB PMC3382223__F2 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes NFKB1 CXCL2 CCL2 RIPK2 IL12A IL20 TNLG5A PMC6135699__F5 Modulating Inflammation through the Negative Regulation of NFKB Signaling TLR4 CYLD IRAK1 TRAF1 RELA TRAF6 MYD88 TNF TAB3 MAL PMC6139543__F11 Proposed alternative metabolic/antidotal pathway of atRAL in the retina LRAT RPE65 RPE PMC6135699__F3 Modulating Inflammation through the Negative Regulation of NFKB Signaling CXCL13 TRAF3 RELB CXCL12 TRAF2 PMC10875024__F6 CCN3 involvement in cell apoptosis and FGFR2 signaling pathways ZNF385A POU4F1 FRS2 PTPN1 TP63 CCN3 FRS3 BANP PHF20 FGFR2 POU4F2 PMC8971671__F8 CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome CX3CR1 ROCK1 CX3CL1 SMAD2 SMAD4 ARHA BAX PMC10875024__F8 Key signaling pathways regulating stem cell pluripotency TCF3 SOX2 SKIL NODAL APC LIF REST EMB BMP4 STAT3 PMC9120357__F3 Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases VPS35 PINK1 MFN2 HEL-S-130P PMC2888634__F4 Drug-induced DNA damage may be repaired by various DNA repair pathways, or apoptosis may be triggered as a result of attempted repair of platinum-induced damage by the Mismatch Repair pathway FHIT NPRL2 RRM1 FANCD2 DHFR EME1 XPC RAD51 ERCC1 XPA BRCA1 PMC5577343__F2 Schematic overview of the 57 meta-signature genes, their literature-based localisation and involvement in the mid-secretory phase endometrium ABCC3 EFNA1 ID4 DEFB1 MAOA TSPAN8 APOD DKK1 G0S2 MMP7 S100P ANXA2 ARID5B SERPING1 TCN1 SFRP4 ENPEP CRABP2 LAMB3 MAP3K5 GADD45A ACADSB CLDN4 IL15 EDNRB IGFBP1 COMP HABP2 PRUNE2 CP HEL-S-62p OLFM1 SLC1A1 GNLY DPP4 NNMT ANXA4 AOX1 CEBPD AQP3 CFD ARG2 opn GBP2 CD55 CFB DYNLT3 BCL6 IDO1 GPX3 MT1G C4BPA EPHA2 PMC5787545__F1 Gut microbes on innate immune receptor TLR4 NLRC4 NPS IL17A NOD2 CP MX1 MLN PMC6108866__F4 Role of EpCAM in cell signaling LEF1 PC EPCAM APC FHL2 LRP6 ERAS DKK2 PMC6463300__F1 HGF/MET signaling pathway HGF GRB2 RHO RAC1 CRK PMC5784884__F5 Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study BACE1 GNPAT BAD GSK3B GPR132 APP FABP5 KDSR CD36 HEL-S-5 PMC4202148__F6 Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma USF1 ITGB8 ROCK1 WASL VAV2 PMC5819907__F1 Calcium signaling pathway, with red font indicating target genes PLN BCR CAV3 MCU CAV2 PMC9304552__F3 Metabolic Regulation of Cardiac Regeneration NAMPT ERBB4 OGA ERBB2 PITX2 PDK3 ACSL1 PDK4 MTOR PCK2 NR1C1 MCAT PMC9439853__F4 Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review RUNX2 BMP2 ATF4 STAT3 PMC8236623__F1 Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance EGF EGFR MTOR PMC8100889__F3 Breast Cancer Therapeutics and Biomarkers: Past, Present, and Future Approaches MICA CDK4 IPP BRCA1 CDK6 PMC7865698__F1 Inflammation and cancer connection pathways COX2 IL1B ELL STAT3 PMC2476215__F3 Brick by brick: metabolism and tumor cell growth HEL-S-133P GLS PMC4631974__F2 Activation of PPARG by bioactive lipids can modulate signaling in progressive colorectal cancer MUC1 KLF4 NOTCH3 PMC6135699__F2 Modulating Inflammation through the Negative Regulation of NFKB Signaling TLR4 IRAK1 RELA TRAF6 MYD88 TNF TAB3 MAL PMC8004172__F2 Molecular components of the host contributing to the modulation of the immune response during human metapneumovirus (hMPV) infection TBK1 TANK IRF7 IFITM3 TRAF3 TRAF6 IRAK4 IRF3 MYD88 LAG3 MAP3K7IP1 TLR3 TLR7 TLR4 TIRAP TAB3 PMC1820751__F3 Ras signaling pathway relays growth signals from activated growth factor receptors to the nucleus NF1 CS GAB2 GRB2 PMC5874888__F4 Hypoxia on HIF-1A LONP1 P4HA1 VHL SIAH2 MTOR HEL-S-133P SLC25A1 HK2 CTGF PMC3382223__F3 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes transduced with Ad-Slug BASH TACR1 CCL18 PROCR IL20 SERPINF2 PMC8917441__F10 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis HEL-S-11 CAST MYC PTEN HEL-S-69p PMC3996583__F2 Construction of the FB-iPSC-CM regulatory circuit RIPPLY2 SOX2 FBRS LIF KLF4 TBX5 MEF2C GATA4 ISL1 CP PMC9206264__F1 Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness CHEK2 BRCA2 BRIP1 BARD1 RAD51 BRCA1 PMC8917441__F11 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis CD14 POR FADD TIRAP PMC11504336__F2 Complex pathological processes during PCO formation under oxidative stress SMAD2 APC LRP5 SMAD4 LRP6 PMC9647626__F2 microRNAs associated with the pathogenesis and their role in regulating various signaling pathways during Mycobacterium tuberculosis infection EGF TRAF6 BCL2 MYD88 TLR1 TNF MTOR TGFA FADD STAT3 MAL PMC3240703__F2 Glycosylated Synaptomatrix Regulation of Trans-Synaptic Signaling ALK TG PMC3327812__F7 Protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2 IL6 GPS2 TRAF2 IRS1 PMC8712703__F6 Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis VASP BAD FYN HEL-S-28 SHE RHO PMC10244910__F10 Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGFB/Smad signaling pathways SMAD2 TGFBR2 PMC11504336__F3 Role and mechanism of Grx1 and Grx2 in protection against PCO formation HEL-S-28 APC LRP5 LRP6 CDH2 PMC7312739__F2 Combinatorial treatment approach of Nuclear factorKB (NFKB) inhibition and immune checkpoint blockade MUC1 EGFR IFNG PMC9670202__F2 When the clock ticks wrong with COVID‐19 ACE2 TMPRSS2 PMC7312739__F1 Transcriptional and posttranslational regulation of programmed-death ligand 1 (PD-L1) by Nuclear factorKB (NFKB) MUC1 EGFR IFNG PMC11941770__F1 Differentiation of T helper (Th17) Cells and Interleukin-17A (IL-17A) signaling pathway TRAF5 SMAD2 APC TRAF6 TRAF2 STAT3 PMC9478335__F3 Adipose tissue macrophage in obesity-associated metabolic diseases TNF IRS1 IL1B PMC8110445__F9 拟康氏木霉胞外多糖联合奥沙利铂可体外协同抑制结直肠癌细胞的增殖 MYB BAD F8 AGK SYK PTEN COL1A1 CD19 PMC9001662__F8 In DR, increased levels of LPS activates the inflammasome in typical and atypical forms NLRP3 IL1B GSDMD PMC5842119__F1 NAD+ intermediates: The biology and therapeutic potential of NMN and NR SIRT2 NAMPT PARP1 NMNAT3 SIRT3 NAPRT SIRT7 NMNAT1 SIRT4 SIRT5 SIRT6 NMNAT2 PARP2 SIRT1 PMC8119568__F1 microRNAs: New-Age Panacea in Cancer Therapeutics DGCR8 DROSHA RAN PMC4041276__F8 Signaling pathways mediating DON-induced RSR, including the MAPK (A, blue), NFKB (B, red), AKT and AMPK pathways (C, green) TSC2 IL18 TSC1 MYBBP1A SNIP1 GSK3B SRC IL6 PDCD11 MTOR PMC6641538__F2 In eukaryotes, iron acquisition is mediated through metal or metal-siderophore transport FECH FXN PMC12197721__F3 Proteins encoded by multigene family genes (MGFs) involved in the NFKB signaling pathway NLRP3 KPNA4 KPNA2 KPNA3 PMC4342984__F6 The figure shows a scheme illustrating the ASARM-model and the pharmacological effects of SPR4-peptide (bimodal) in HYP and wild type mice FGF23 DMP1 PMC12197721__F2 Proteins encoded by multigene family genes (MGFs) involved in the type I IFNs signaling pathway TBK1 STAT1 CGAS STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC3696998__F9 Comparison of CK2 knockout defects and Wnt pathway knockout defects, with a schema to indicate where in the pathway CK2 is believed to act LEF1 SACS PMC8126961__F3 Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts DHFR PMC3198803__F5 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae PTS TBP GAL NOD2 PMC7930427__F2 Molecular Profiling of Exceptional Responders to Cancer Therapy AMER1 HHIP CD14 BRAF LEFTY2 GSK3B HNF1A GAS1 CDC25B THBS4 DDX50 TNC GTF2H3 TMUB2 MNAT1 CSF1R GRB2 FZD7 GNAS LAT IL2RB PLA2G10 PMC7775471__F3 NAD+ biosynthesis pathways NAPRT NAMPT HEL-S-90n NADSYN1 NRK PMC3198803__F7 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae PTS TBP COPA GAL PMC9571692__F1 New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects NQO1 PMC8408558__F8 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway DKK3 GSK3B LRP6 SFRP1 DKK2 TCF4 PMC4190587__F3 MicroRNA Regulation of Smooth Muscle Phenotype PIM1 MYOCD KLF5 KLF4 SRC ARHA RHO CCND2 PMC9693225__F3 Shared Proteome of the Apomictic Fern Dryopteris affinis ssp. affinis and Its Sexual Relative Dryopteris oreades EIF4A1 SHD PGM2 RIN1 ENO1 PMC7877184__F8 Morphine-3-glucuronide (M3G) promoting non-small cell lung cancer (NSCLC) immune escape via toll-like receptor 4 (TLR4) and programmed death ligand 1 (PD-L1) CD14 TLR4 MYD88 PMC3715730__F3 Ingenuity pathway analysis (IPA) of Interferon Signaling Pathway of genes differentially expressed in the bronchial epithelial cells exposed to Alternaria alternata spores STAT1 AK2 STAT2 IRF9 PIAS1 IRF-1 IFNG IFIT1 PMC4754058__F1 The Notch1 signalling pathway RUNX3 IGF1R RUNX1 NOTCH1 PMC4666670__F4 Transcriptome Analysis of Plant Hormone-Related Tomato (Solanum lycopersicum) Genes in a Sunlight-Type Plant Factory HEL60 PMC7806419__F7 Schematic of the possible signaling pathway of leukocyte immunoglobulin‐like receptor A3 (LILRA3) HLA-G LILRA3 HLA-C PMC4535966__F2 Ingenuity pathway analysis reveals an up-regulation of the NOTCH pathway in LGR5 high SW480 spheres compared to LGR5 low SW480 adherent cells NUMB JAG2 HES1 PMC7751369__F10 Protein-protein and gene-gene interaction networks among CCNB2, CCNE2, CDK4, HOMER1, HSP90AA1, NRAS, PPP2CA, PRKAA2 and RAC1 CCNA2 TMCC2 PRKAA2 HOMER3 HOMER1 NRAS TMCC3 RAC1 CDKN2A PPM1B CDK6 MOB4 CCNB3 TEX28P2 SGK2 CDKN2B CDK2 CCNB2 PPP2CA DKFZp686H13261 CDK4 CCNE2 PMC9597306__F5 Recent advances in hydrogels-based osteosarcoma therapy MMP2 RUNX2 BMP2 PMC5309296__F5 Phosphoproteomic analysis of SK-ChA-1 cells after ZPCL-PDT ERBB2 ZYX FLNA RPS6KA4 BAIAP2 IQGAP1 MAPK14 PAK4 MAPK1 SOS1 IRS1 PXN PMC9237413__F5 Proteomic Analysis of Hypothalamus and Pituitary Gland in Pre and Postpubertal Brahman Heifers GNRHR MMP2 EGFR GRB2 HBEGF FSHB LHB CAMK2A CDC42 PMC10635949__F5 Effect of BD exposure during adolescence on skeletal muscle metabolism and myokine secretion SPARC FGF21 ULK1 FOXO3A LIF MTOR BDNF IRS1 PMC5166973__F7 Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer MYC EIF4E PMC12232815__F8 Mechanism diagram of BYHWD NAMPT OGDH TFAM PMC1951533__F14 Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling EGR1 GRB2 SRC LHB PMC4339020__F1 TNFA in Cerebral Ischemia: Another Stroke Against You? TRADD CASP8 FADD BAX PMC4645376__F6 Schematic overview of M1 protein-induced IL-8 expression in human keratinocytes IRAK1 TRAF6 IRAK4 MYD88 TIRAP PMC3530555__F5 Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways IGF1R IGF1 PMC5711528__F2 Interactome of lupus susceptibility genes, constructed using Strings software (version 9.0; http://string-db.org) via evidence‐based protein–protein interactions AFF1 IKZF3 PRKCA NMNAT2 DRAM1 NR3B3 FCGR2B MSH5 ATG12 IRF7 IRF8 CSK GPR19 RICTOR C8orf7 PRKCB DHCR7 PPP2CA TNFAIP3 IFIH1 UBE2L3 C4B_2 FCGR2A TFRC IL12A MTOR DKFZp686F0183 SGA56M RPTOR FKBP1A TLR7 IKZF1 PLD2 TET3 JAZF1 CD2AP SH2B3 IL10 WDFY4 ATG16L1 ELF1 KIF3A RAB4A TNLG2B BLK PTPN22 ITGAM ATG16L2 ICAM3 RASGRP3 BANK1 STAT4 LYN TREX1 TYK2 SLC15A4 CR2 IKZF2 DNASE1 NCF2 PMC5711528__F1 Metabolic pathways controlling activation and lineage specification in the immune system VLDLR HEL164 LDLR CD44 RAB4A JAK1 STAT3 CD36 FOXP3 PMC2683667__F4 Induction of IFN-signaling pathways in HCV-infected uPA-SCID mice (A) and patients (B) STAT1 STAT2 IRF7 IRF9 F7 IRF3 IFNGR2 TYK2 JAK1 IFNGR1 PMC7871366__F3 Pathway paradigms highlighted by IBD genetics KEAP1 FCGR2A NCF4 RIPK2 NOD2 NLRP7 CEBPB OSMR IFNG RSPO3 RIPK1 AHR BACH2 IL17RA HGFAC NOS2 IL1B RORC ATG16L1 LRRK2 NLRC4 IRGM RNF186 PTGER4 TNF IL23R PTPN22 CARD9 HNF4A SDF2L1 TMEM258 STAT4 LACC1 TYK2 IL2RA IL6ST TRAF3IP2 TNFAIP3 IFIH1 IL18RAP OSM MEFV GPR65 PMC7232014__F1 Autophagy pathway overview, with childhood-onset neurodegenerative diseases affecting the pathway either directly or indirectly highlighted in red font TSC2 SPG11 ATG101 MTOR ATG14 SNX14 RHEB GABARAP PMC7871366__F2 IBD genes and pathways controlling mucosal immunity KEAP1 NCF4 IFNG RFT1 RSPO3 HGFAC NOS2 IL23R IL12B PRKCB TMEM258 NXPE1 IL2RA ITGAV TNFAIP3 IFIH1 NR5A2 SLC39A8 ITGA4 RIPK2 NOD2 SLC39A11 AHR IKZF1 BACH2 JAZF1 SH2B3 RORC IL10 SCAP2 TNLG1B SLC22A23 GCKR ATG16L1 LRRK2 ERGIC1 NKX2-3 RNF186 PTGER4 hCG_1998026 PTPN22 CARD9 HNF4A STAT4 LACC1 CD40 IL6ST TRAF3IP2 MEFV GSDMB GPR65 PMC3554558__F1 Putative role of VHL-HIF-EPO pathway in RCC progression EPOR EPO VHL PMC7090218__F2 Metabolic pathways affecting ferroptosis HEL-S-102 GPX4 LPCAT3 FACL4 SLC7A11 CISD1 ADA IREB2 DKFZp686F0183 PMC7611989__F2 TH effects on hepatic autophagy GNE ULK1 CPT1A FUNDC1 MED1 CAMKK2 PMC4270942__F7 Estrogen Regulates Energy Metabolic Pathway and Upstream AMPK Kinase and Phosphatase Enzyme Expression in Dorsal Vagal Complex Metabolo-Sensory Neurons during Glucostasis and Hypoglycemia PFKL PMC8643130__F2 Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies NLRP3 IL18 NGF IL1B PMC9250978__F2 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways TBK1 IRF7 IRF3 MAVS PMC5752873__F1 Wnt signalling pathways and their interactions NLK DAAM1 APC ARHA SIAH2 PMC3407640__F8 Summary of pathways with differentially expressed genes comparing sarcomas to MSC in the current study CDK2 SMO ARHA CDK4 PMC9250978__F1 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways TBK1 CGAS DDX41 IRF3 MRE11A AIM2 IFI16 PMC8468334__F2 Type I Interferons in COVID-19 Pathogenesis TANK STAT2 IRF9 ACE2 IRF2 MAVS PMC4899583__F3 Schematic shows the potential role of epigenetic mechanism that may be involved in manganese induced chronic neurotoxic effects and in pathology of Parkinson's disease SNCA BAD FGF20 PMC6710795__F8 Proposed model of dovitinib-mediated autophagy and apoptosis with regard to the SHP-1/p-STAT3 pathway in breast cells CCND1 MCL1 STAT3 PMC5826526__F5 Eukaryotic initiation factor 2 (eIF2) signaling pathway ELL3 ELF5 ELF3 F2 EIF2A GRB2 EIF4E EIF5 INSR PMC12073636__F1 Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk TLR4 NPS INS MYD88 MUC2 PMC7106760__F8 Schematic illustration of ADAM10 regulates E-cadherin/Beta-catenin signaling pathway which in turn is regulated by miR-122-5p ADAM10 PMC8161379__F2 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy PINK1 ULK1 LASS1 ULK2 PMC8161379__F1 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy CER1 DES SPHK1 CERK SPHK2 SMS HEL-S-5 PMC6992891__F1 Effect and regulation of the NLRP3 inflammasome during renal fibrosis NLRP3 SMAD2 SMAD4 IL1B PMC2763495__F1 Metabolic pathways of growth and proliferation MYC PTEN EIF4E CIT HEL-S-133P PMC7956893__F5 PPI induces protective autophagy through the PI3K/AKT/mTOR pathway by inhibiting AKT (S473), mTOR (S2448), p70S6K (T389), and 4EBP1 (T37/46) and increasing the conversion of LC3I conversion into LC3II EGF RICTOR MTOR PMC2763495__F4 AMPK–p53 pathway in metabolic adaptation TIGAR SCO2 CPT1C PMC6628043__F7 Biofunction analysis of differentially expressed genes from eWAT (A) Biofunction-overlay of the disease and function related to lipolysis in eWAT; (B) the disease and function in response to CLE in eWAT ADORA2B EGF PLCL2 ADIPOR2 ANXA1 PRKAA2 ADRB1 VEGFA CD44 ATF3 LPIN2 TNF G0S2 LEP NR1i1 STEAP2 LIPA LPIN1 ACACB LGALS12 HCAR2 OSM PNPLA2 PMC5659363__F2 HCMV-encoded agonists of the NFKB signaling pathway IL16 ATM RELA PMC5659363__F1 HCMV-encoded antagonists of the NFKB signalling pathway RELA RELB IL1B PMC3322224__F2 cAMP Signaling CascadeLigand binding (represented in this example by PTH, but other ligands and receptors can stimulate cAMP synthesis), activates GsA and stimulates cAMP synthesis by adenylate cyclase PDE4D PRKAR1A PTH PMC7956893__F2 Anticancer molecular mechanisms of PPs ATF4 EIF2A MTOR PMC7956893__F1 Molecular anticancer mechanisms of PPs GSK3B IL6 STAT3 PMC7956893__F4 PPs inhibit cancer cell proliferation and induce apoptosis in cancer cells through the NF-kB and MAPK pathways EZH2 CASP8 BAX PMC8656686__F2 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers HMGA2 CBX2 IGF2BP1 METTL3 TGFBR1 TGFBR2 YY1 TPD52 MTOR IGF2BP2 BRD4 PMC8750516__F1 Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer BAD BIK BMF HRK BAX PMC5815310__F3 Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease NOX4 MTOR SIRT3 PMC6554677__F1 A model for the regulation of T cell-mediated adaptive immune responses to apoptotic cells APC CD80 PMC2775805__F6 Molecular pathway analysis of genes regulated in the NAc by the HDAC inhibitor MS-275 after chronic social defeat stress STAT2 EGFR REST RHO ADRA1A JAK1 TGFA PMC8656686__F3 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers CBX2 GC HNRNPA2B1 TPD52 PRDX5 BRD4 PMC9586150__F3 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis SPARC LIMK1 COL3A1 FOS BMP2 TGFBR1 VCAN ADRB2 PIGS PTEN POR LEP MAX F3 GNG2 APP CCND1 TOX MYLK PMC9586150__F6 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis HEL-S-11 TGFBR1 TGFBR2 PMC3724517__F4 Pathway analysis of differentially expressed genes in RAF265 responding versus nonresponding tumors MYB GIPR PICALM PMC9586150__F8 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis F3 TGFBR1 MAPK14 TGFBR2 PMC7935675__F1 After activation of the S subunit protein on the COVID-19 surface by transmembrane protease serine 2 (TMPRSS2), the virus binds to the Angiotensin-converting enzyme 2 (ACE2) receptor and infects the host cell through endocytosis ATR ACE2 ADAM17 TMPRSS2 PMC2757293__F2 Innate immune evasion by hepatitis C virus and West Nile virus STAT1 TRAF3 IRF3 TYK2 JAK1 PMC5036175__F6 Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus PEX19 PC PMC5272809__F2 New View into the Regulation of Purine Metabolism – The Purinosome ADSL PAICS HEL-S-70p PMC5272809__F1 New View into the Regulation of Purine Metabolism – The Purinosome ADSL PAICS HEL-S-70p PMC5526580__F1 Impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer IGF1R HGF IGF1 EGFR GRB2 MTOR STAT3 PMC8858844__F1 Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment NLRP3 NLRC4 GZMA AIM2 GSDMB GSDMD DFNA5 PMC8752857__F4 P38 MAPK pathway in Bactrocera dorsalis ATF2 MAP3K7 MAP3K5 MAP2K3 PMC6349817__F2 Crosstalk between the PI3K-Akt-mTOR pathway and the Hippo-Yap pathway via SIK2 SIK2 AMOTL2 IGF2 PMC8052339__F6 Working model of LPS-induced RAGE signaling in sensory neurons innervating the upper airways IL10 TLR4 CREB1 SRC IL6 TRPV1 PMC6406281__F1 Cholesterol homeostasis in normal cells LDLR ABCA1 HMGCR PMC6273859__F7 Possible signaling pathways for tetrandrine-induced apoptosis in NPC-TW 076 human nasopharyngeal carcinoma cells BAX PMC8364652__F5 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy ATM ATF4 MDM2 ATR BAX PMC12135389__F1 CGAS-STING pathway and its cellular and disease functions TBK1 CGAS IRF3 TYK2 IFNAR2 JAK1 TNF IFNAR1 PMC8364652__F6 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy KEAP1 ATM LIPG KLF14 HEL-S-44 PRDX3 BRCA1 NQO1 PMC7520847__F4 Hedgehog pathway SUFU GLI3 SHH SMO PMC6714236__F7 A schematic model depicting the functions of SNAI3‐AS1 in HCC SMAD2 PMC7520847__F2 Wnt signaling pathway APC AXIN1 LRP5 LRP6 PMC4178212__F2 Activation of p53 is predicted to increase the flux through gluconeogenesis PC PCK1 PCK2 PMC7520847__F1 RAS signaling pathway TSC2 TSC1 GRB2 PTEN IRS1 RHEB PMC4252580__F2 Aldosterone on insulin sensitivity and secretion RAB14 IGF1R SRC RAC1 ACTN4 IRS1 SGK1 PMC8886057__F2 ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids MCCC2 OXCT1 MCEE BCAT2 HADHB DLD ACADSB OXCT2 PCCB ACAT2 ABAT ACADS MCCC1 ECHS1 EHHADH ACADM PMC8894377__F4 Radiotherapy alters expression of molecular targets in prostate cancer in a fractionation- and time-dependent manner EGF TANK NGF TRADD HEL-S-71 RELB TRAF6 MYD88 MAP3K7IP1 UBE2V1 CARD11 LTA RELA LCK ZAP70 TGFA FADD TIRAP TAB3 PMC6769012__F6 BK ablation attenuates osteoblast bone formation via integrin pathway RUNX2 SRC RAF1 PMC6871180__F3 Molecular mechanisms of arrhythmogenic cardiomyopathy NF2 GSK3B LATS1 LATS2 PMC11566304__F1 Metabolic pathway diagram of hypoxanthine PURA PURB THRA PMC10918650__F1 l-isoleucine biosynthetic pathway in E NR1A2 THRA PMC12103977__F1 Comparative framework for the integrative analysis of cardiovascular phenotypes MYH7 PMC3916222__F2 Mathematical Modeling of the Phoenix Rising Pathway HEL-S-62p COX2 C7 PMC4209854__F1 EGFR signalling in chronic lung disease EGF IER2 HBEGF TGFA PMC3589091__F1 Pathways of PI5P synthesis and turnover PI3 FIG4 PIKFYVE PMC9297570__F5 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states ERBB2 IMPACT EGFR PMC4574301__F1 Intestinal epithelial barrier function plays an essential role in maintaining intestinal health IKBKG IL22 TTC7A ADAM17 PMC11053710__F2 Cross-talk of Dyrk1B in signaling pathways in development and disease PTCH1 GLI3 RLF SMO MTOR DYRK1B PMC7200761__F7 Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R IGF1R BRAF HAT1 PMC8002730__F3 Core signaling pathways of triple negative breast cancer (TNBC) HIF1A HEL-S-26 MGAT4A EP300 MMP2 TP53INP2 ERBB2 CXCR4 ILDR2 BCL2 CCL28 MTDH STAT3 CDC42 PMC6797170__F5 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach RAN AXL LIPN CP PMC3398464__F1 Key branches of the insulin signaling cascade TSC2 SULF2 GRB2 APOC3 NOX4 PTEN IRS1 PDPK1 RHEB PMC8002730__F5 Common and distinctive core signaling pathways between triple negative breast cancer (TNBC) and non-triple negative breast cancer (non-TNBC) MAPK9 PGR MYC RAP2C GABARAPL2 EP300 MMP2 TP53INP2 ERBB2 CXCR4 ARRDC3 ILDR2 BCL2 CCL28 MTDH S100A4 CDC42 PMC9134593__F1 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases TBK1 TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR10 TLR3 TLR8 TLR7 TLR4 IL1B TAB3 MAL PMC8002730__F4 Core signaling pathways of non-triple negative breast cancer (non-TNBC) GABARAPL2 EP300 MMP2 PGR TP53INP2 CXCR4 MYC ILDR2 BCL2 CCL28 RAP2C CDC42 PMC6797170__F7 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach F10 TFPI PLG THBD F8 F9 SERPINC1 A2M F2 F5 F3 VWF F11 F7 SERPINA1 SERPINF2 PMC9134593__F3 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases TBK1 TRADD IRF7 TRAF3 TRAF6 IRF3 TRAF2 IL1B MAVS PMC9134593__F2 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases NAIP NLRC4 IRF7 NLRP1 IL13 NLRP12 NLRP6 TRAF3 IRF3 RIPK2 MAP3K7IP1 NLRP7 GSDMD NLRP3 IL16 NLRC3 MAVS NLRP10 TAB3 PMC4559511__F2 Complement and adaptive immunity HEL-S-62p BCR APC CD80 CR2 IFNG PMC8321669__F10 RNA-seq analysis indicates Chemical carcinogenesis inhibition in M3−/− crypts ME1 SKI CYRIA MAL PMC6797170__F4 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach FGA c-fgr HRG CS CFB APC POR HEL111 FRK AHSG LBP APOH CP PMC4559511__F1 Complement cascade HEL-S-62p PMC11464740__F3 JAK/STAT signaling pathway can be activated or inhibited by inflammatory cytokines to regulate the inflammation of UC TYK2 IFNG PMC6044892__F8 Speculated biosynthesis pathways of glycosylated products elongated on a saccharide primer CS GAL PMC11894581__F6 PPI networks CTBP2 GPC4 NUMB PROS1 HEL-S-1 POSTN MAP2K3 HEL-S-104 CEBPB ADAM17 OLFML3 opn VWF MFAP4 SFRP1 JUNB ZNF185 MYOC KRT85 NFATC1 RPS9 SPCS3 HSPG2 VTN FHL2 C1QTNF3 TMPRSS11E HABP2 PMC5877513__F3 An overview of resveratrol-mediated targeting of multiple signaling pathways SIRT7 ANGPTL4 SMAD2 APC GSK3B LRP5 SMAD4 CXCL8 LRP6 PMC4423606__F4 Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models HEL-S-49 PFKFB1 HEL-S-87p PGAM1 PMC5877513__F1 TGF/TGFR signaling axis SIRT7 ANGPTL4 SMAD2 SMAD4 CXCL8 PMC9297570__F2 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states ERBB2 IMPACT EGFR PMC9297570__F4 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states HGF ERBB2 IMPACT STAT5B PMC6307166__F4 CircRNA-miRNA interactions are potentially involved in the initiation and progression of CRC PI3 APC EGFR PIK3CA IRS1 SPRY2 PMC9297570__F3 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states MUSK IMPACT APC PMC11816596__F1 Canonical Wnt pathway (left): Wnt ligands (such as Wnt1, Wnt2, Wnt3, Wnt3a, and Wnt 8) bind to the frizzled (FZD) receptor and its coreceptors LRP5/6 (LDL-receptor-related proteins) APC GSK3B ARHA ROR2 RAC1 PMC2700428__F2 Some cellular processes implicated in the pathogenesis of PAH EGF BMPR2 KDR PMC3202302__F1 Signaling by the TNFR superfamily in B-cell biology and disease NFKB1 GC CD40 TRAF2 PMC5101203__F1 Putative pathological production of AB and NFKB signaling in neurons BACE1 EGR1 EGR2 NPY BDNF PMC3202302__F2 Signaling by the TNFR superfamily in B-cell biology and disease BCR RELB CD40 PMC3202302__F5 Signaling by the TNFR superfamily in B-cell biology and disease TRAF3 TRAF6 CD40 TRAF2 PMC6216024__F1 Hedgehog signaling pathway KIF7 SUFU SMO PMC3202302__F4 Signaling by the TNFR superfamily in B-cell biology and disease BAD GSK3B RELB TRAF3 PLCG2 PTEN FOXO1 BTK PI3 BASH STS SYK TRAF2 CD19 PMC9362470__F1 Sulfide metabolite formation and fate CTH ETHE1 CYS1 PMC9044756__F10 Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer APC PMC5523822__F2 Altered B cell signalling in autoimmunity BCR CD40 WAS PTPN22 PMC8617922__F1 Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm SOCS3 IL6 SUMO1 PMC9433872__F6 Research progress on RNA−binding proteins in breast cancer HMGA2 VASP MYC CREB1 LATS1 MSI2 PMC9120625__AF1 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression GSK3B RB1 BDNF PMC3175751__F2 Schematic Overview of Nodal and Cripto-1 Signaling Pathways NODAL SMAD2 SMAD4 SRC PMC3188749__F3 Simplified schematic presentation of the transcriptional hierarchy of essential factors and signaling pathways during endocrine specification of the pancreatic endoderm PDX1 PROX1 PAX4 PMC4118249__F9 Theoretical structure of this triple-hit nALI model as a translational study TLR4 AREG MYD88 PMC6173119__F2 Regulation of intestinal cholesterol absorption and role of the Niemann-Pick C1-like 1 protein (NPC1L1) at the enterocyte level in humans ABCG8 ABCG5 NPC1L1 TG HEL-S-104 MTTP HMGCR ACAT2 HEL-S-5 PMC8703276__F1 Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks DHFR PMC2723786__F1 BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells ATM CD40 ATR CHEK1 IRF4 BCL6 PMC4865891__F6 Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery after Hindlimb Ischemia IL-21 STAT3 BAX PMC7486457__F8 Proposed model for the relationship between NRF2-FOCAD-FAK signaling and cysteine deprivation-induced ferroptosis GPX4 FTH1 RPA1 FTL AKR1B1 PMC9661362__F2 Central Adiponectin Signaling – A Metabolic Regulator in Support of Brain Plasticity TSC2 ADIPOR1 ADIPOR2 TSC1 INS NR1C1 APPL1 PMC7352710__F1 A-proliferation inducing ligand/B cell maturation antigen (APRIL/BCMA) pathway and its biological effect in the multiple myeloma bone marrow microenvironment BIRC3 CCND1 BCL2 MCL1 TG CCL3 FOXP3 PMC6347560__F1 Ribosomal stress (RS) pathway and its hypothetical role in neurodevelopmental syndromes NPM1 MDM2 POLL POLI PMC8546207__F4 Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development VCAM1 CD40 CD80 TNF IL1B PMC3931013__F3 Wnt signaling pathway represented by KEGG analysis PLCB3 MAPK9 FZD3 NFATC4 TBL1X ROCK1 GSK3B SMAD4 SENP2 DKK1 MMP7 FZD2 CCND1 FZD7 SFRP1 TCF7L1 NFAT5 APC LRP5 CER1 LRP6 WIF1 NLK PLCB4 PLCB2 RAC3 CREBBP NFATC2 EP300 CHD8 APC2 TCF4 PMC7325303__F1 Apoptosis in health and disease: the balancing act of BCL-2 family proteins BAD APAF1 MYC BCL2 MCL1 HRK PMC3736724__F1 Tyrosine kinase (TYK) targeting growth factor and proliferation pathways PIGF FLT1 KDR CSK NRP1 FGF2 ITGAV RAF1 VEGFB CRK PMC6824075__F10 Working model for the SULF2‐LAPTM4B‐dependent autophagic pathway in HCC cells LAPTM4B SULF2 PMC8898188__F1 Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules FOXC1 NLK APC GSK3B SOX9 PMC8533955__F2 Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism IGF1 INS PMC9185410__F3 Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion HMGB1 IL33 MLKL PMC3263503__F8 Schematic depiction of crosstalk between Notch and HIF-1A CREBBP VHL EIF4E STAT3 HEL-S-68p PMC7968318__F4 VIRMA and circ_KIAA1429 involved in human cancer progression GIG8 MYC CDC2 VIRMA TNF GATA3 PMC7505271__F4 Relationships between mitochondrial and norepinephrine dysfunctions HEL-S-62p C9 DBH ALDH2 PMC6752849__F10 Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor AHR GSK3B PMC3691204__F1 Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma HHIP PTCH2 KIF7 SUFU PTCH1 GLI3 SMO PMC11274091__F3 Interrelationship of major pathways and coexisting inflammatory mediators between oxidative stress and inflammatory process in excisional skin wound healing IL10 NLRP3 COX2 MPO CRP IL6 LPO REL PMC8022410__F8 GSK3B rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs GSK3B DSPP DMP1 PMC4509139__F3 Map of the Wnt signaling pathway, which includes at least three Wnt signaling pathways, namely the canonical pathway, the planar cell polarity pathway and the Wnt/Ca2+pathway ING4 BAMBI ROCK2 NLK DAAM1 APC SOST CER1 SMAD4 SKP1 ARHA PMC11203986__F10 DAXX-associated pathway SUV39H1 SETDB1 PMC8155577__F2 Ancient Adversary – HERV-K (HML-2) in Cancer IL10 TLR8 IRF7 MDM2 IRF3 TLR3 TF MAVS PMC7005898__F6 Proposed function of HadDMtb in the mycolic acid biosynthetic pathway of M PMC8222669__F2 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases MAF KEAP1 GCLC AKR1C1 NOX4 RBX1 NQO1 PMC9508752__F3 Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure TH AGA TES PMC8222669__F6 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases KEAP1 MTOR STAT3 PMC6361458__F5 Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients’ skin fibroblasts HEL-S-62p POSTN ALG13 SVIP C14orf133 EDIL3 ATG10 DTL CLSPN CDKN1A opn IGFBP2 DNAJB7 DIPLA1 CCNE2 PMC7505271__F2 Relationships between mitochondrial and serotoninergic dysfunctions HEL-S-62p C9 GSK3B PMC6028704__F1 Sub-network with a size cut-off of 28 between D-glucose and L-phenylalanine in S PC GIP PHETA1 CIT PMC9468880__F2 Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells TSC2 EEF2K RICTOR TSC1 CASTOR1 MSX2 PTEN EIF4E MTOR SGK1 RHEB PMC10353343__F4 Gene expression changes for genes in the Toll-like receptor 4 (TLR4) Signaling Pathway CD14 BTK VCAM1 IRAK1 LBP TRAF6 ECSIT IL6 MYD88 TAB3 MAL PMC6526306__F6 BCAA mediate resilience to stress by inducing the hippocampal BNDF/TRKB signaling through the PGC1a/FNDC5 pathway HPD BDNF FNDC5 PMC3858599__F1 NAD+ metabolism, a therapeutic target for age-related metabolic disease NAMPT HEL-S-90n COCH NRK PMC4570748__F7 Redox control of the cellular energy metabolism ATM HIF1A MTOR PMC2374962__F2 Regulation of glycolysis and fatty acid synthesis TIGAR SCO2 CPT1A FASN PMC8832002__F7 S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3B/Beta-Catenin Signaling APC GSK3B LRP5 LRP6 CDH2 COL1A1 S100A4 TCF4 PMC3789189__F8 CVB3-induced the PI3K-Akt-mTOR-apoptosis signaling pathway TSC2 TSC1 PMC4102553__F5 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment COX2 COX1 PMC4102553__F4 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment ALOX12 HEL110 ARSI PMC6321704__F1 Simplified reference TLR signaling pathway projected onto putative homologs in Trichoplax sp IRF3 IRF4 TRAF4 TAB3 PMC3822957__F11 P60TRP signalling based on the results obtained from different systems including NSCs, PC12 cells and p60TRP transgenic mice BACE1 MAP2 CDK5 APP NOTCH1 ADAM10 CDH2 PMC3975365__F3 So-called PI3-K/Akt/mTOR survival pathway TSC2 BAD C9 TSC1 MDM2 PTEN RAC1 MTOR RHEB BAX MYT1 PMC2812788__F1 HDL, ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses CD14 TLR4 ABCG1 MYD88 ABCA1 IL1B PMC3975365__F2 Tumor’s interaction with its solid microenvironment BAD GRB2 SRC PMC3975365__F1 Apoptosis induction and signaling SET CAD PMC3752265__F5 Example of differences in use between glycolysis and the ED pathway by representative cells in our modeled population LDHD TNLG7C RPE PMC7533558__F9 How CRLF1 promotes HLF formation MMP2 CRLF1 IL1B HLF PMC7792207__F4 Survivin and interaction with apoptotic pathways XAF1 FADD PAF1 PMC7912776__F1 Genetics of extreme human longevity to guide drug discovery for healthy ageing TSC2 TSC1 IGF1 GSK3B TBC1D7 LRP5 GRB2 LRP6 IRS1 RHEB INSR PMC5466966__F1 Major Anti-tumorigenic pharmacological properties of thymoquinone MMP9 SRC BCL2 CDK4 STAT3 PMC5650339__F8 miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3B/Beta-catenin signaling pathway ZNRF3 AGO2 GSK3B PMC7792207__F3 Pathway involving the non-canonical NF-kB activation through NF-kB-inducing kinase (NIK/MAP3K14), modulated by cIAPs TRAF3 RELB CD40 TRAF2 PMC3979117__F1 Schematic illustration summarizing apoptotic signaling through the death receptor pathway and the mitochondrial pathway BAD DKFZp781B1423 MDM2 SIRT1 PMC10971254__F8 Binding of IL-25 to its receptor induces the transcription of IL-25 responsive genes via the TRAF6/NFKB-dependent signaling cascade and TRAF4/MAPK/AP-1-dependent signaling pathway TRAF6 IL25 IL17RB TRAF4 PMC8540239__F3 An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations CD14 LBP TRAF6 TIRAP PMC4574248__F2 Signal transduction pathways and the oxidative stress response MED13 CDK8 CCNC PMC8065760__F3 Involvement of the significantly dysregulated microRNAs in renal cancer signaling pathways EGF EGFR VHL MTOR PMC1168613__F1 Comparison of the D MYD88 REL FADD PMC11711753__F6 Extending a canonical pathway with PTMNavigator ROCK2 BRAF MOS ARHGEF7 SOS2 ROCK1 YBX1 MAPK3 NUP214 GSK3B MAP2K2 ARHA ERF SGTA MAP2K1 MAPK6 RPS6KA1 MAPK4 CIC MAPK1 CDC2 RAF1 SOS1 PMC11711753__F4 Analysis of a phosphoproteomic perturbation dataset in PTMNavigator BRAF EGFR GSK3B MYC TBC1D7 EIF4E MTOR IRS1 RPTOR RHEB TSC2 RICTOR GRB2 RPS6 PMC9502658__F2 Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic IRF7 IRF3 ACE2 TMPRSS2 PMC3735083__F1 HIF-1A regulation in cancer PML PIN1 CDC2 MTOR KLHL20 PMC7910460__F4 Crosstalk between HIFs and mitochondrial dysfunctions in cancer development PINK1 MFN2 VHL HEL-S-51e TG NPAS2 MXI1 NR1C1 PMC9108985__F1 Cellular proteostasis in antitumor immunity HSF1 PMC4292903__F2 Biomarkers Linking PCB Exposure and Obesity FGF4 NODAL FGF2 FOXD4 FOXO1 CP PMC4607614__F6 Schematic representation of SA’s mechanisms of suppression of HMGB1’s proinflammatory activities HMGB1 TLR4 CXCR4 PMC3739146__F7 NAC protects against Cd-induced germ cell apoptosis by inhibiting UPR signalling in the testes CD2 EIF2A XBP1 PMC6885792__F2 The role of MYOF in membrane trafficking MYOF EGFR VEGFA PMC8170419__F3 Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug targets ChAT OMP SI SHE MEA1 PMC6885792__F3 Role of MYOF in EGFR-related pathway MYOF EGF EGFR PMC8255612__F1 BMP Signaling in Endothelial Heterogeneity BMPR2 SMAD6 SMAD4 PMC4984662__F8 Bunyavirus-induced Wnt/Beta-catenin signaling APC GSK3B LRP5 CCND1 LRP6 BCL9 PMC4729952__F3 Peroxisomes, fatty acid beta-oxidation and the human deficiencies of peroxisomal beta-oxidation DBP LBP PTH2 ACOX1 PMC3193402__F2 Crosstalk between RANKL- and TNF-induced NFKB signaling in OCs TRAF3 RELB TNF PMC5798385__F7 Proposed model for regulation of S6 phosphorylation (P) by the cAMP/PKA pathway TSC2 TSC1 DEPTOR RHEB MLST8 PMC8463593__F10 BAFF is involved in B cell differentiation and activation through the NFKB signaling pathway in RA CD27 CRP CD19 PMC3193402__F1 Classical and alternative NFKB pathways in skeletal cells RELB TNF PMC5411693__F6 Hypothesized altered feedback control of the POMC gene promoter in cells having USP8 or RASD1 mutations (mut) versus wild type (wt) POMC RASD1 CRH EGFR PMC8712487__F2 Myosin 1g and 1f: A Prospective Analysis in NK Cell Functions ISG15 MYO1F MYO1G PMC4459616__F3 Effect of sclerostin inhibition on Wnt signaling.Notes: Sclerostin is secreted by the osteocyte GSK3B TEF LRP5 LRP6 PMC8667691__F1 Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer DBR1 AGO2 DGCR8 DROSHA RAN PMC4459616__F1 Wnt signaling pathways and the biology of sclerostin.Notes: (A) Canonical Wnt signaling: in the absence of sclerostin, Wnt binds to LRP 5/6 and its co-receptor, frizzled GSK3B LRP5 LRP6 PMC9061994__F4 ROS-Influenced Regulatory Cross-Talk With Wnt Signaling Pathway During Perinatal Development APC GSK3B PMC8483823__F4 Profile analysis of circular RNAs in cervical cancer TH CD14 DAO MAX EPX PMC3000367__F5 Scalable Approach for Discovering Conserved Active Subnetworks across Species PLK2 FGF4 CD47 MYBL2 SOX2 FOXF2 C3AR1 PTPRC RARB GNG4 SIRPA FCER1G ZIC1 LCK CCNB1 GHRHR TUB CD93 ZIC3 PMC9114355__F1 Adipose Tissue Derived Exosomes in Metabolic Disease CD9 CD63 CD81 PMC5620210__F2 ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway FYN APC GSK3B SRC MTOR CDC42 PMC7432514__F3 Human diseases linked to eIF2 Ser-51 phosphorylation stress responses and the mTORC1 signaling pathway ELF2 TSC1 ATF4 MTOR RHEB PMC7875453__F2 BCR signaling pathways TRAF6 PLCG2 BTK CD72 BCL10 GIG8 BCR BASH NFKB1 RELA CD22 SRC SYK TRAF2 PMC12154905__F3 Scheme of the identified TNF signaling pathway, with genes identified by changes in mRNA levels in NS1-treated human lung microvascular endothelial cells (HLMVECs) compared to untreated control cells TH PAX2 LIF TRAF3 IL6 TNF NOD2 MMP3 CASP3 MMP14 CYLD TRAF1 CD2 CAD TNFAIP3 TRAF2 IRF-1 FADD MLKL SELE ITCH PMC8266488__F3 Sex Hormones and Gender in the Gut Microbiota SRC SP1 TF PMC5777791__F9 Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer CCND1 SKP2 BAX PMC6772763__F8 Multiple signaling pathways regulate the cell death pathway in sympathetic neurons NGF JUN BAX PMC7407234__F6 Proposed model for MX1’s role in ERS-mediated cell fate ATF4 XBP1 MX1 PMC11702355__F2 Classical and non-classical Wnt signaling pathways MMP7 APC WNT1 MYC CCND1 PMC7975969__F3 Suppression effect of starvation in anorexia nervosa on mTOR system and end organ results MTOR DEPTOR IRS1 RHEB PMC7975969__F2 Nutrient effects in activation of mTOR system and the end-organ results MTOR DEPTOR IRS1 RHEB PMC8871376__F1 Adenylosuccinate lyase (ADSL) in de novo purine synthesis (DNPS) and the purine nucleotide cycle PFAS ADSL GMPR ADA PAICS HEL-S-70p PNP ADK PMC6459027__F1 Thiamine metabolism DKFZp667O1614 HEL107 THTPA PMC10990754__F1 Various intracellular signaling molecules and pathways involved in HSCR IHH PHOX2B NRG1 PSPN ARTN PROKR1 NRTN PROK2 NTF3 RET ZEB2 SHH GDNF SEMA3C SOX10 SEMA3D GFRAL KIFBP PMC4962366__F8 Gene network ASIP AgRP MC3R MC2R KNG1 PMC8810962__F4 Estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet GABRB3 UBQLN1 SLC32A1 GABRB1 GABRQ GABRA2 GABRB2 SLC6A11 GABRA3 GABRA4 PMC10990754__F3 NcRNAs related to cell apoptosis, proliferation, migration, and differentiation in HSCR RET SRGAP1 PTEN E2F3 PLCB1 GFRA4 PMC4281037__F4A IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing TBK1 TRAF5 GSK3B TRAF3 TRAF6 USP25 TRAF2 IL17RC TRAF4 TAB3 PMC5545069__F2 Iron Overload and Altered Iron Metabolism in Ovarian Cancer STEAP3 PCBP1 PMC9283756__F2 Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis KLF15 CRP ARX CYP7A1 PMC7648632__F1 PD-L1 degradation pathway and immunotherapy for cancer ATM CMTM6 EGFR GSK3B CDK4 SPOP CDK6 TCF4 CMTM4 PMC8834120__F3 Landscape of PDK1 in Breast Cancer TSC2 EGR1 BAD MDM2 RHEB PMC11947053__F2 Research progress and prospect of MAPK signaling pathway in knee osteoarthritis FOS MYC TRAF6 RAC1 TNF ETS2 OSM TRAF2 JUN PMC8834120__F4 Landscape of PDK1 in Breast Cancer TSC2 GRB2 ARHA AMIGO2 RHEB PMC9384889__F8 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking LCN2 REL PMC7971348__F2 Ubiquitin-proteasome pathway influences proteostasis, the cell cycle, and filamentation CYR61 CDC20 APC SKP1 PMC9384889__F7 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking JUNB TNF TRAF2 CA12 NOD2 FADD MLKL ITCH PMC7648632__F2 PD-L1 degradation pathway and immunotherapy for cancer EGF PC CMTM6 EGFR GSK3B ADAM10 B3GNT3 ADAM17 PMC7071987__F1 Fundamental knowledge on IL-17 biology CXCL1 EBP CXCL5 TRAF6 CCL2 TNF IL17RB TRAF2 IL17RC PMC1805736__F6 Pathways for synthesis of adrenal steroids CYP11A1 CYP17A1 CYP11B2 PMC3640439__F1 Induction and evasion of type I interferon responses by influenza viruses TLR8 TLR7 IRF3 MYD88 TLR3 MAVS PMC4706689__F2 IL-10 Anti-inflammatory Signaling Pathway is enriched for putative differentially expressed genes (Progressors vs NonProgressors Enrichment False Discovery Rate adjusted P-value = 0.0287) Figure is a stylized representation of the Biocarta pathway HEL-S-10 STAT4 TNF IL10RA STAT5B PMC9097893__F2 NLRX1 Deficiency Alters the Gut Microbiome and Is Further Exacerbated by Adherence to a Gluten-Free Diet TH NLRP1 IL33 NLRX1 TRAF3 RELB CXCL12 TNF TRAF2 NLRP7 PMC8921673__F1 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration GSK3B ABO IRS1 PMC10454639__F11 Regulatory pathway map of roots suffering Mn poisoning in soybean FER CAST PMC4706689__F1 IL-10 and integrin signaling pathways are associated with head and neck cancer progression FGA COL18A1 ITGB3 ITGA2B JAM3 ITGA7 ITGAM HEL-S-78p ITGB8 opn VTN THBS1 ITGAX ITGAV COMP AGRN PMC5638382__F1 Different endothelial responses to different patterns of flow EGR1 ATF2 KLF4 ARHA KLF2 PMC6893739__F2 Merlin signaling PAK1 CD44 LATS1 RAC1 MTOR LATS2 PMC7559019__F4 Various factors influence the occurrence of liver cancer PC NF2 PTEN HRAS PMC8921673__F2 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration PDE3B GSK3B GRB2 APP SHE TBC1D4 PMC7848033__F1 Role of Osteocytes in Modifying Bone Matrix Properties CTSK SOST PTH COL1A1 DMP1 PMC7925099__F15 The action of PAV-206, a possible first-in-class selective inhibitor of HIV-1 assembly XRN1 PMC3265866__F7 PGC-1Alpha- and AMPK-mediated regulation of IL1Rn expression in hepatocytes CRP IL1RN IL1B NR1C1 PMC5889282__F7 BGN- and DCN-mediated inhibition of the TGFB pathway and restriction of HER-2/neu signaling DCN EGFR TGFBR1 TGFBR2 PMC9532189__F1 Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition MGP GPX1 PMC8699554__F4 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges TH GIG8 opn CD48 S100A12 FOLR2 FCN1 HEL-S-104 IL1B PMC7072680__F1 gp130 cytokines and receptors activate downstream signaling pathways CNTF EBI3 LIF CNTFR OSM OSMR PMC8699554__F1 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges APC CRP IFNG PMC7299830__F3 Eribulin combined with irinotecan inhibits DNA replication and induces TP53 pathway genes PML SCO2 DKFZp781B1423 JMY ATF2 GSK3B GML PTEN TNF HIF1A STAG1 WT1 BRCA1 PERP BCR PIAS1 MDM2 CD40 PCNA BAX PMC420513__F4 Immune synapse_related signaling pathway and autoimmune diseases PLCG1 FYN RUNX1 CD2 LCK CD80 SLC22A4 LAT CBFB PDCD1 NAT9 PMC7757038__F1 Exosome biogenesis and composition TSG101 RAB35 CD9 CD63 RAB27A CD82 RAB27B ARF6 RAI1 CD81 PMC5694456__F9 Schematic illustration revealing the anti-inflammatory effects of gApN on microglia ADIPOR1 TNF IL1B PMC3881972__F1 Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals: a review of recent research CD14 TLR5 TRAF3 TRAF6 IRF3 MYD88 NOD2 TLR3 COX2 CARD9 TLR4 NOD1 TIRAP CD36 PMC4987160__F4 Genomic Landscape of Male Breast Cancers TES FANCA MUTYH PMC5932347__F1 RIG-I-like receptors and toll-like receptor (TLR) 3 signaling pathway TBK1 TANK IRF7 TRAF3 TRAF6 IRF3 MAVS PMC3048839__F10 Schematic representation of IH-induced increase in adrenal medullary NPY by activation of reactive oxygen species (ROS) signaling pathway CTSL PMC7828553__F2 FGFR signaling pathway FRS2 GRB2 PMC4384349__F5 Schematic presentation of VEGFR-1 activation in CC tissue and its association with metastasis PIGF VEGFA VEGFB PMC12111897__F6 Signal transduction pathways for the Al+ADAl3–4 vs BAK1 BIN2 MKS1 EBF2 TF PMC3592471__F8 Functionally related pathways of aberrantly methylated and differentially expressed genes in immortalized MEFs TM4SF13 PHOX2A REM2 SOSTDC1 MAPK11 SP1 MED9 CP PMC7819155__F2 Roles of the lncRNA H19 in osteogenic differentiation RUNX2 PMC12120737__F5 PCSK9 activated the EGFR/HER3 signaling pathway in TNBC cells PCSK9 EGFR LDLR SRC CCND3 HEL-S-162eP PMC9395634__F4 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes BAMBI C1QTNF1 RGS5 RIDA MT2A CRIM1 TAC3 TNF RPS16 TCIM PAX8 PMC5386953__F2 Signaling Pathways Controlling Microglia Chemotaxis VASP SRC CD36 PMC9395634__F3 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes ADAMTS2 CRTAP IFRD1 TRMT1 DST COL5A2 AF1Q ADAMTS15 ADAMTS14 PMC3848550__F2 Schematic representation of the sialic acid metabolism pathway in eukaryotic cells NEU2 NEU4 NEU1 NEU3 GAL ST6GAL1 PMC8509620__F8 Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway ROCK2 CCNA2 CDK2 CCND1 CDK4 LPA LPAR1 PMC7797432__F2 SFRP-2 in the Wnt/Beta-catenin signalling pathway in cancer BRAF APC GSK3B PMC5993148__F3 SLC7A11 regulates nutrient dependency of cancer cells SLC7A11 SLC3A2 GLS PMC3013243__F9 Myeloid-specific GPCR kinase-2 negatively regulates NFKB1p105-ERK pathway and limits endotoxemic shock in mice TLR4 IL1B ADRBK1 PMC11240502__F2 Tryptophan metabolites interact with AhR and potentially interfere with serotonin and melatonin synthesis ASMT AHR CYP1B1 CYP1A1 CYP1A2 AANAT PMC11240502__F1 Effects of UVA and UVB radiation on skin tryptophan lead to pro-inflammatory pathways COX2 AHR EGFR PMC3291637__F2 Proposed differences in the localization of Fe-S cluster biogenesis proteins in S ABCB7 CIAO1 ISCU NDOR1 NUBP1 NFU1 PMC8347979__F4 ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer MMP2 MMP9 SRC ADAM17 PMC3291637__F1 General scheme for biogenesis of Fe-S clusters in mammalian cells FES ISCU NFU1 NUBPL BOLA3 PMC8909058__F4 Relevance of Aquaporins for Gamete Function and Cryopreservation AQP11 AQP3 PC HP AQP7 AQP8 AQP9 PMC10245950__F12 Glycolysis in cardiomyocytes is upregulated in the oxaliplatin treated mice ALDOB ENO3 HK3 FBP2 HEL-S-30 ENO1 GCK HEL-S-87p HEL-S-68p HEL-S-162eP ENO2 PGAM1 HEL-S-133P PGAM2 HK2 HEL-S-281 PMC10245950__F13 Effect of oxaliplatin on NAD+ and NADP+ synthesis and salvage pathways SIRT2 NUDT12 NAMPT ENPP1 ENPP6 NADK ENPP4 NNT NMNAT3 SIRT3 SLC25A51 NMNAT1 SIRT4 ENPP2 BST1 SIRT1 ENPP3 PNP PMC10474743__F4 Advances in immunotherapy for triple-negative breast cancer MUC1 CGAS CTLA4 PMC5992481__F1 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis SMAD2 TGFBR1 TGFBR2 SMAD4 PMC3856112__F7 Combination of pathway topology and ab initio reconstructed network HSPB7 RABEPK UBE4A GYG1 MYL6 KCNK3 DHX29 SP110 SEC31A HPD TBX1 KCTD10 PTMA FGL2 ESRP2 SST AATF MDC1 LAMA4 PS1TP5BP1 HEL-S-273 CSRP2 PSPH IGFBP2 HEL113 PMC5992481__F5 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis SMAD2 TGFBR1 TGFBR2 SMAD4 PMC4114960__F4 Viral-Induced Rewiring of Host Metabolism Leads to an Increase in Fatty Acid Biosynthesis PSPH PHGDH HEL-S-162eP PMC6165581__F2 Illustration of miRNA biogenesis pathway and mode of gene regulation AGO2 DGCR8 DROSHA RAN PMC5490158__F4 Upstream regulators identified by Ingenuity Pathway Analysis, predicted to participate in the regulation of gene expression upon A2B-adrenoceptor activation in A7r5A2B vascular smooth muscle cells AHR CX3CL1 NPPB CCL2 PMC9158472__F6 NFE2L3 as a Novel Biomarker Associated With IL-2/STAT5/NLRP3 Signaling Pathway in Malignant Pleural Mesothelioma and Other Cancers IL10 NLRP3 IL13 NFE2L3 IL4 IL5 PMC7604315__F2 Neddylation and HCC SAG VHL NEDD8 PMC5873813__F2 Broad overview of the genetic architecture of inflammatory bowel disease giving examples of confirmed and candidate genes implicated in each pathway ATG16L1 LRRK2 CCR6 IRGM TNFRSF6B IL23R CAPN10 XBP1 hCG_1998026 NOD2 TAGAP MTMR3 TLR4 ORMDL3 IL27 TYK2 STAT3 PMC3457296__F8 LMP2A induces signaling pathways that promote membrane localization of AV-integrin and epithelial migration GSK3B SRC SYK PMC5977110__F5 Pathways that influence YAP and TAZ in lung cancer ABL2 EGF RASSF1 EGFR LATS1 LPA LATS2 PMC4817727__F3 Role of axin in Wnt signaling in bone APC LRP5 LRP6 PMC4817727__F4 Role of RGS proteins in selected GPCR signaling in bone PTH1R RGS5 CASR NFATC1 RGS18 RGS2 RGS12 RGS10 PMC5977110__F1 Hippo pathway core components and their upstream regulators LATS1 RHO LPA LATS2 PMC5977110__F2 Main proteins and pathways that influence YAP and TAZ in lung development and tumorigenesis ABL2 EGF RASSF1 AMOT EGFR CRB3 LATS1 LPA LATS2 PMC5585663__F1 The Nrf2/Keap1/ARE pathway in type II diabetes mellitus KEAP1 HEL-S-44 NQO1 PMC3873541__F7 Enriched canonical pathways of miRNA target genes IGF1R BAD SOCS3 MAP2 MAPK8 RARA MNDA PTPN11 CASP9 NOS2 ARG1 JUN RUNX1 FOS IRS1 NEDD4 MAP2K1 IGF1 GRB2 JAK1 RAF1 FLT3 GRB10 SHC1 PXN MEF2C STAT3 PMC9181071__F1 Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway EGF HDAC2 MYD88 MTOR TG PMC6973314__F11 Role of BST2, E-cadherin, and signaling pathways in IFN-Gamma-mediated decrease in invasion of HTR-8/SVneo cells STAT1 BST2 PMC10245950__F10 TCA cycle is affected by oxaliplatin CS MPC1 ACO2 MPC2 SUCLG1 SUCLA2 OGDH IDH3B SUCLG2 SDHA MDH2 PMC10706216__F16 Activation of UPR signaling pathways during ER-stress, caused by TAA injections, in liver cells ATF4 TRAF2 BAX PMC6131589__F1 Sights and mechanisms of mHTT toxicity in yeast models of HD HEL-S-62p KMO HTT PMC2894449__F1 Stages of apoptotic cell engulfment and associated cell signaling events that regulate each stage CD14 ARHG LAMP2 CR1 CD36 PMC8926903__F1 Genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer CRY1 RORC CRY2 RORB NR1D2 NPAS2 NR1D1 PER3 PER1 DKFZp686O2183 PMC4813390__F3 Influence of TGFB‐SMAD and TGFB‐TAK1 signalling on adrenoceptor‐mediated pathways in LV heart failure progression TGFBR1 TGFBR2 PMC3474280__F1 Central position of the locus coeruleus in relation to the acoustic startle reflex and pupillary light reflex pathways RET CS LAT PMC5693031__F7 Tight junction pathway overrepresented among Qki5 HITS-CLIP target genes based on DAVID-KEGG pathway analysis PATJ ERBB2 CASK PALS1 CDK4 RHO PTEN RAB3B CDC42 RAB13 PMC4693890__F3 Cytokine signalling networks in women with chlamdyial infections (a) or gonorrhoea (b) were evaluated using Ingenuity Pathway Analysis CCL11 LTB CCL4 PMC6678762__F6 Schematic diagram illustrating the proposed SIRT1 signaling pathway involved in PGC1A/mitochondrial biogenesis that exerted an endogenous protective mechanism in the hippocampal neuronal tissue following experimental status epilepticus NRF1 TFAM SIRT1 PMC11897032__F1 Pathways of serine synthesis and metabolism SHMT1 HEL-S-51e PHGDH PMC5343774__F2 Summary of cross-talk between cancer cells and the tumour microenvironment mediated through the 5-lipoxygenase pathway KPG_011 LTC4S PMC8207819__F1 Regulated cell death pathways at a glance TBK1 TANK GPX4 TRADD FACL4 SLC7A11 POR ZBP1 GSDMD TSG101 NLRP3 RIPK1 APAF1 CYLD CASP8 BAX CYB5R1 RIPK3 CDC37 HMGCR SHARPIN SLC3A2 OTULIN FADD MLKL PMC5343774__F3 Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway IL1B FOXP3 PMC4917709__F2 Negative modulation of EMT by sirtuins SIRT2 MMP7 SIRT4 SMAD4 PMC6884928__F2 Phosphatidylinositol 3-kinase (PI3K)/pAkt-kinase pathway as a central CCL5/CCR5 signalling cascade in cancer cells CCR5 SRC PTEN PMC2781509__F1 Folate-mediated one-carbon metabolism SHMT1 PMC6651563__F1 G protein-coupled receptor (GPCR) signaling DISC1 GSK3B RHO PMC8238141__F7 Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells RICTOR LONP1 RB1 KDM5A PMC5581716__F2 The ferroptosis pathway and the inducers and inhibitors of ferroptosis GPX4 SLC7A11 TRO SLC3A2 CPO PMC7143295__F2 Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway schematic representation of the Canonical Wnt Pathway and pharmacologic inhibitors of the Wnt/beta-catenin signaling pathway PC TNIK GK3 PMC9347991__F1 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate TNF ACE2 PMC9347991__F3 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate NLRP3 HMGB1 TLR4 IL1B SIRT1 PMC9376458__F5 Transcriptome Analysis of Dendrobine Biosynthesis in Trichoderma longibrachiatum MD33 DHDDS MVD FDPS MVK GGPS1 HMGCR PMC9347991__F2 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate NLRP3 TLR4 ACE2 SIRT1 BAX PMC12139089__F5 Hippo signalling contributes to renal fibrosis and damage in diabetic conditions SMAD4 LATS1 SMAD1 LATS2 PMC2974775__F4 Ca2+ waves activate transcription factor NFAT that in turn controls cell cycle MYC ORAI1 STIM1 PMC3676649__F2 Musashi signaling pathways associated with mammary progenitor cell expansion NUMB MSI1 DKK3 JAG2 GSK3B MYC LRP5 NOTCH1 CCND1 LRP6 PMC5041099__F3 Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s disease ADORA2B CXCL5 RASSF4 ZFP36 MNDA FOSB SIN3A JUNB CASP8 RLN1 NAMPT QPCT LIMK1 FOS IL8RB TCF7L2 BCL2A1 LILRA5 EGR2 FOXN2 pp6425 HLX GNB5 IFITM3 MAN2C1 PATL2 DPP4 HEL-S-15 CEACAM21 CFL2 IL1R2 IL1R1 LPAR1 GCG MGRN1 IL18 MYO6 STAP1 SSH1 TNLG1B EGR1 NMB IER2 S100A12 DKFZp686L24211 SLC22A4 AQP9 TNFRSF25 NFKB1 TNFSF10 ADA IL18RAP SRGN FADD IL18R1 PMC6690608__F1 Metabolic reprogramming in CRC COX2 PHGDH FASN GLS PMC8235403__F14 Orthosiphon stamineus Proteins Alleviate Hydrogen Peroxide Stress in SH-SY5Y Cells HP PTGES FKBP4 PMC5328835__F1 Role and mechanism of action of Sclerostin in bone LRP4 SOST LRP5 LRP6 PTH TNF PMC12139089__F3 Activation of transforming growth factor 1 (TGFB1) signalling in the development of DKD SMAD2 SMAD4 MTOR TGFBI STAT3 PMC6499508__F6 Graphical summary CCR2 IL8RB TNF TG HMGCR UCP2 IFNG PCSK9 APOB IL18 TLR4 PC TNFSF14 ABCG1 SREBF2 LDLR NR1C2 ABCA1 GATA3 FASN CD36 BOK PMC3945336__F1 Mannose and glucose metabolic pathway PMC7202519__F7 Our hypothesis that exercise training suppressed inflammatory and apoptotic pathways and enhanced IGF1R/PI3K/Akt survival and anti-aging AMPK/SIRT1/PGC-1A associated pathways in the hippocampus of D-galactose induced aging rats COX2 IGF1R FADD SIRT1 PMC5595348__F11 HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection TLR7 IFNA1 EEA1 TRAF3 TRAF6 IRF3 MYD88 MAP3K7IP1 IL1B PMC8627624__F1 Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation PI3 LYN PTEN PMC3841320__F4 Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells EGR1 DUSP5 GNA15 CCL20 FGFR3 SFRP1 THBS1 ETS2 HOXA5 LAMA3 IFNG PMC11058197__F6 Proposed model of the Notch-ROCK pathway and its biological significance TLR4 JAG2 NOTCH1 NOS2 HES1 PMC3927127__F2 Cytokine-induced differentiation of human B cells in vitro: requirement for IL-21 signaling in vivo IL10 IL21R BCR CD40 JAK3 CD80 STAT3 PMC6562797__F6 Flaccidoxide-13-acetate-induced apoptotic pathway in bladder cancer cells BAD H1-1 ATF4 EIF2A BAX PMC4131533__F8 Interaction network of differentially expressed miRNAs and their targets: network construction can be divided into two components: miRNA-target and target-target interaction, and candidate miRNA targets were predicted by mRDB ID4 BMP2 PITX2 SMAD2 TGFBR1 TGFBR2 SMAD4 SMAD9 IFNG FST NOG RPS6KB1 ACVR2A SMURF2 PPP2CA INHBB RBL1 INHBE PMC3714205__F2 Signaling via by cytokines and growth factors and its negative regulation by SOCS proteins SOCS2 SOCS3 SOCS4 SOCS7 SOCS5 SOCS1 PMC6946658__F1 Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy SMOX PAOX SLC3A2 AMD1 SMS PMC8870127__F1 Bright and the Dark Side of TGFB Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications SMAD2 TGFBR1 SMAD6 SMAD4 PMC1949901__F1 Current understanding of the pathways of fatty acid synthesis which are known to occur within the Brassicaceae HEL-S-62p PC PMC7817624__F1 Metabolic pathways in breast cancer cells HEL-S-30 MYC ACLY HIF1A MTOR HEL-S-133P FASN GLS PMC7566085__F4 Identifying Drug Sensitivity Subnetworks with NETPHIX BTK BCR ATM DKFZp781B1423 ERBB2 EGFR MYC MDM2 VILL RB1 PMC5858971__F2 Targeting the IL-6/JAK/STAT3 signalling axis in cancer SOCS3 PDLIM2 PTPN1 SRC SOCS1 STAT3 PMC7248678__F2 Routes of pDC sensing CGAS TLR7 TLR9 IRF7 DHX36 IRF3 MYD88 PMC5858971__F1 IL-6 signalling pathways ADAM10 ADAM17 STAT3 PMC9389045__F6 Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis CREBBP EPO TIMP1 PDHA1 RALA BCL2 HEL-S-133P AMT HEL-S-162eP PMC8304605__F1 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease SUFU PTCH1 GSK3B BCL2 IGFL1 SMO PMC6820656__F5 Ovarian cancer pathway enriched by target genes of the identified miRNA biomarkers in IPA EGF MMP9 EGFR PTEN RB1 DVL1 FGF9 MTR COX2 MMP2 SRC CDK4 FSHR PMC8304605__F3 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease TCF4 PMC8692171__F1 PTEN-PI3K-AKT-mTOR pathway and therapeutic targets TSC2 TSC1 PKD1 PTEN SGK1 RHEB PMC4366240__F7 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 SCD ACLY MTOR FASN PMC4366240__F4 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 MCRS1 MAPK3 SNCAIP NME2 GPS2 NOP2 MON2 EWSR1 PRNP TRIM23 TRIAP1 MDM2 EMP2 CSNK1A1 GNAS SLK HEL-S-93 DYRK2 PCNA HSPA4 WWOX BAX PMC3570128__F2 Wnt signaling affects c-Myb stability and activity NLK HIPK2 FBXW7 PMC3588076__F3 Regulatory networks of mTOR inhibitors and miRNAs in controlling the mTOR pathway in cancer TSC2 ULK1 TSC1 IGF1R ELF3 PTEN EIF4E PMC3588076__F2 mTOR signalling pathway TSC2 RICTOR ULK1 TSC1 PTEN EIF4E MTOR DEPTOR RHEB MLST8 PMC2760340__F2 Representation of NF1 interactions with the Ras and PI3K pathways NF1 GRB2 PTEN MTOR PMC6168666__F3 CARD14/CARMA2 variants in keratinocytes RNF7 BCL10 TRAF6 DEPDC7 ULK2 TRAF2 PMC11883231__F7 Proposed biosynthetic pathway of polyphyllins in P SSR1 SSR3 SSR2 PMC6567317__F2 Known mechanisms and signaling pathways involved in histone deacetylase inhibitor-activated induction or suppression of autophagy MDM2 CASP9 MTOR PMC6589502__F2 Generalized Lymphatic Anomaly and Gorham–Stout Disease: Overview and Recent Insights VEGFC PI3 EFNB2 PIK3CA MTOR GLA EPHB4 PMC5130266__F10 Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling SMAD2 HDAC5 PMC10484181__F3 Potential mechanism of P2X7R overexpression causing tumor progression COX2 NFATC1 ARG1 PMC101242__F7 Up-regulation of RAD51 in 8-MOP-treated cells RAD50 RAD52 RAD51 PMC9359065__F1 PERK promotes immunosuppressive M2 macrophage phenotype by metabolic reprogramming and epigenetic modifications through the PERK-ATF4-PSAT1 axis PSAT1 ATF4 IL4 PHGDH PMC4058660__F2 PI3K signaling in neural aging and disease GSK3B MTOR PMC3136910__F2 Proposed model of ATF2 regulation of Ha-Ras signaling ATF2 TPR REL PMC9165365__F3 “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders MCU PMC3970925__F1 Activation of PPRs in cardiomyocytes by DAMPs during myocardial I/R injury HMGB1 TLR4 TLR9 PMC3997674__F2 Signaling pathway of TRAIL/drug combinations SP1 STAT3 BAX PMC4817553__F1 The Hedgehog signalling pathway in Drosophila and vertebrates KIF7 SUFU SMO PMC3997674__F1 Dual opposing signaling pathways of TRAIL BCL2 TRAF2 FADD PMC8705692__F1 Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence TH PNMT DBH NTS PMC3470479__F1 The Genetics of Alcohol Dependence: Advancing Towards Systems-based Approaches CYP2E1 HEL-S-117 ALDH2 PMC3164695__F7 The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO IGFBP1 GADD45A SIRT1 PMC8555307__F4 Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR10 TLR3 TLR8 TLR7 TLR4 FADD TIRAP PMC7053243__F9 Schematic diagram showing the proposed mechanism of MYC inhibition by excess BASP1 protein competing for binding to CaM MAX MYC BASP1 PMC3672537__F2 Postulated interaction between the insulin signaling pathway and activation of the pro-inflammatory cascade in the pathogenesis of insulin resistance in sepsis CD14 TLR4 LBP TNF IRS1 PMC6647379__F3 Tumor microenvironment influences the metabolic status of cancer cells with consequences for their metastatic potential LDLR CA9 HMGCR CD36 PMC8835992__F7 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis CDK2 CDK4 CDC2 CDK6 PMC6912706__F2 SGA-induced impairment in hepatic insulin signaling and glucose metabolism IRS1 FOXO1 PMC7003246__F2 Targeting the CD47-SIRPA pathway in cancer SIRPA CD47 PMC8213534__F1 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review TRADD IRF7 TRAF3 IRF3 MAP3K7IP1 TLR3 PMC2945462__F1 Complement cascade is comprised of the Classical, Alternative, and Mannose Binding Lectin pathways CS C7 C6 C1S C4A PMC6854696__F5 Schematic diagram of miR-889 regulates osteoblastic differentiation of hBMMSCs by targeting WNT7A and through Wnt Beta-catenin signaling pathway WNT7A LRP5 LRP6 PMC7854845__F2 UPF1 Activation in the Two Major NMD Branches SMG9 SMG8 UPF2 SMG1 DHX34 UPF3B PMC8835992__F8 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis RUVBL2 FOXM1 GRIP1 TDG LRRFIP2 EGFR SMYD2 GSK3B FOXK1 NRARP RBX1 SOX4 CARF SOX11 DLL4 FHL2 SHH BARX2 HMGB2 TCF4 TERT PMC2660918__F2 Hypothetical model for the end-joining mechanisms during CSR ATM RAD50 PARP1 MSH2 ATR UNG MRE11A WRN PMC2481274__F2 Type I Interferon: Potential Therapeutic Target for Psoriasis? STAT1 PML IFIT2 STAT2 TYK2 IRF2 IRF-1 PMC6034319__F3 Cross-talk between tumor, MDSCs and immune cells for development of HPV-related carcinogenesis EGF CXCR4 CCL5 CCL2 CXCL12 PMC8213534__F2 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review TLR3 MAVS TICAM1 PMC8928433__F7 Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo TLR4 HNF4A IRF3 MYD88 PMC3268188__F2 Tumour suppressor p53 regulation and signalling RRM2B ATM MDM2 ATR HTRA2 BAX PMC8618298__F4 Current Status of Photodynamic Diagnosis for Gastric Tumors ABCB6 FECH UROD UROS HMBS CPOX ABCG2 PMC8209385__F5 Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis SNAI1 MLF1 THBD ID4 GSTM1 PTGER4 HTR7 MTOR CR1 SFRP5 IFITM1 MAF HBA2 TBX21 MMP2 KLF4 OXT IRF4 GATA3 FZD8 CCNE2 GNB4 PMC7331465__F1 IL-7R Signaling Drives Proliferation and Survival while Preventing Premature Igk Recombination Programs During B Cell Development in Mice BAD RAG1 MYC IL7R BCL2 MCL1 MTOR CCND3 RAG2 FOXO1 BRWD1 PMC6545067__F6 Graphic conclusion HMGA2 CCND1 PMC8039208__F4 Effects of circRNAs on the Warburg effect-associated signaling pathways ENO1 HEL-S-133P HK2 STAT3 FLOT2 HEL-S-68p HEL-S-162eP PMC11898978__F2 Tissue fragmentation and mechanical manipulation disrupt the ovarian Hippo signaling pathway, promoting follicle growth LATS1 LATS2 PMC8909324__F12 Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy CS PTEN SUMO1 PMC11898978__F1 PI3K/AKT signaling pathway is a key regulator of primordial follicle activation TSC2 KIT TSC1 PTEN RPS6 MTOR PMC11952802__F4 Periosteal microenvironment on P-SSCs SFRP4 NGF RUNX2 POSTN CD200 PMC10149907__F5 Regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer HEL-S-26 OGDH HEL-S-68p PMC7789501__F2 Protein–protein interactions for the differentially expressed proteins in ApoE−/−/LDLR−/− mice (vs SAA4 APOB CS PROS1 VCAM1 GUGU F7 APOC3 PZP SAA1 THBS4 HEL-S-130P PMC6484007__F1 STIL: a multi-function protein required for dopaminergic neural proliferation, protection, and regeneration STIL SUFU SHH SMO PMC4765526__F1 Cartilage matrix homeostasis is regulated dynamically by the TGFB signaling pathway SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC4066991__F1 Missing Link between Itch and Inflammation in Atopic Dermatitis TRPA1 TSLP STIM1 ITCH PMC6488142__F1 PI3K/Akt /mTOR pathway TSC2 TSC1 PTEN RPS6 MTOR PMC8483511__F3 Molecular pathways linking the CD137 signaling pathway to ECs NFATC1 BCL2 SMAD1 DKFZp781O1323 TET2 BAX PMC8740962__F1 Proposed simplified schematic representation of SARS-CoV-2 induced intracellular pro-inflammatory signalling pathway TLR8 TLR7 TLR4 TRAF6 MYD88 TLR3 TIRAP PMC9450808__F2 Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review) ABCD3 CYP27A1 CYP8B1 AKR1D1 AKR1C4 CYP7B1 BAAT CYP7A1 HSD3B7 PMC7393270__F6 Ingenuity Pathway Analysis (IPA) top regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs FABP2 APOA4 HNF4A APOC2 HNF1A MUC2 OSM FOXA2 PMC2878081__F7 Schematic overview of the pyruvate/isocitrate cycle and OGC, important components of the pathway regulating glucose- and glutamine-stimulated insulin secretion PC CIC GLUD1 PMC3741284__F2 Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis ITGB3 NFIB ADAM12 CREB1 ITGA4 TCF12 SYNGR2 HRAS ITGB1 MAPK15 RET BIK LCK SF1 DAB1 CLEC3A CDC42 PMC7407770__F4 Possible approaches for MASTL therapeutic targeting and the expected biological outcomes from each strategy ENSA ARPP19 MASTL PMC8589435__F3 Canonical Wnt signalling is critical for ISC niche maintenance and is potentiated by Lgr5 RNF43 APC LRP6 GPR49 PMC6039345__F6 Schematic diagram showing the role of Sulfatase-1 in inhibiting mesothelin expression in Carcinogenesis MSLN STAT3 PMC9343807__F1 Hippo–YAP/TAZ Signaling Pathway in Intestinal Self-Renewal and Regeneration After Injury NF2 LATS1 LATS2 PMC3014256__F3 A-Kinase Anchoring Proteins: Getting to the heart of the matter SIAH2 HDAC5 NFATC3 PMC6252330__F3 Regulators of glioma cancer stem-like quiescence in the niche EGF HGF CXCR4 CXCL12 PMC8555377__F3 High frequency of clonal hematopoiesis in Erdheim-Chester disease MAP2K1 U2AF1 BRAF NRAS EZH2 TET2 PMC6252330__F1 Molecular mechanisms underlying cell cycle by cancer stem-like cells TSC2 TSC1 CDK2 CDK4 CDK3 PTEN CDC2 CDK6 HES1 PMC7642714__F8 C-type lectin receptor signaling pathway TH FRY CYLD RELB ARHA SYK PMC10478443__F4 Functional enrichment analysis of IGF2BP1 regulated pathways in B-ALL MXD1 CD9 PLK1 MSR1 HEL-S-99n GNG7 HSPD1 NOL11 CTIF HEL-S-26 GOT2 SOX11 HEL-S-44 DKC1 MAPK1 PNO1 UTP20 SP1 NDUFA6 PTBP1 PRKX ACADSB PRKCB POU4F1 FADS2 FADS1 ABCA1 HEL-S-283 PLEK HLA-DMB TGFB1 APOBEC3C TF S1PR2 STYX RAG1 P4HA1 SHANK3 DHX15 TFRC PROX1 CEBPB CCND2 TIMM50 SENP3 ETF1 RRM2 TSR1 APP RASSF2 COX7B RHOB KLF6 HEG1 KARS1 SH2B3 PER1 SCAP2 HNRNPR RUNX1 ABCF2 MAFF RPA1 HEL-S-34 PTGER4 FUS TLR3 PTPN22 PRPF19 CBL PSMD12 CPT1A ALYREF ACADVL CD40 CSF1 BCL9 HLA-DQA2 KDM6B PLAG1 FHIT IGF2BP1 IRAK1 HEL-S-1 LGALS9 TRIB3 HNRNPL ATF5 NUP62 UNG CRKL STARD4 TP53INP1 GAREM1 SLC2A3 COX10 SURF1 PTBP3 AF1Q HEL-S-133P BHLHB2 AKAP12 ERG Nbla10317 PSMA4 PSMB2 ZDHHC9 ATF3 PSMA2 AK4 GADD45A DDIT4 FOXO1 ADNP TET2 TMEM97 INSIG1 NENF CDKL5 EDEM1 DHCR7 ISG20 WDR4 RHOT2 HEL-75 KLF2 PSMD2 PSMD1 PNP LTV1 HEL2 KLF10 NAT10 CD300A DDX39A AMBP MAP3K15 TNFRSF13C RAP2A BNIP5 PPP1R15A CD109 CSTF2 DCAF13 CKAP4 KLF13 JUN TIMM17A BAX HMGB1 PIK3IP1 SP2 WDR12 MAP2K2 POP1 CRMP1 HEL-S-69p PES1 SYNJ1 RNASET2 AGER BCAT1 PSAT1 ASNS NRP1 ERN1 PRXL2A RNP24 NFIL3 TOMM40 MST065 FLRT3 TNFRSF10B FLT3 RAN CYCS PMC7642714__F9 IL-17 signaling pathway TH COX2 FADD PTER PMC5541421__F4 TREM2 signaling and function LTA PC CCR7 SYK APOE PMC3531240__F11 IFNA and LPS up-regulate APOBEC3 (A3) mRNA through different signaling pathways STAT1 TLR4 IRF3 MYD88 PMC5144739__F1 Interleukin-10 (IL-10) gene transcription regulation TLR4 CD209 SYK MYD88 PMC6443620__F3 Hypoxia-inducible factor-1 (HIF-1) signaling pathway EPO VHL PTEN MTOR EIF4B PMC5695831__F10 Schematic of pathways for transcriptional activation of Forkhead box protein O1 (FOXO1) and IGF-1 in the mouse liver IGF1 IGFBP1 GHR STAT5B FOXO1 PMC8234490__F8 Ergosta-7, 9 (11), 22-trien-3Beta-ol Interferes with LPS Docking to LBP, CD14, and TLR4/MD-2 Co-Receptors to Attenuate the NFKB Inflammatory Pathway In Vitro and Drosophila CD14 TLR4 LBP MYD88 IL1B TIRAP PMC3949135__F1 Schematic Ig synthesis pathway CXCL13 PC APC PMC7668396__F1 PI3K pathway TSC2 KIT CCND1 PTEN RPS6 PMC12125839__F5 Neurodegeneration models in Parkinson’s disease: cellular and molecular paths to neuron death PINK1 LRRK2 TFEB PARK2 MTOR MCOLN1 PMC5603960__F2 Biosynthesis of azaphilone pigments in Monascus fungi MTR H1-1 H1-5 PMC12125839__F2 Molecular mechanisms of mitochondrial damage involved in Parkinson's disease SNCA BAX PMC12011818__F11 Proposed model of HPV E2-mediated suppression of innate immune signaling TBK1 STAT1 CGAS STAT2 IRF9 IRF3 IFNAR2 JAK1 IFNAR1 TLR3 MAVS PMC6099942__F7 DBTD decreases the intracellular TG by promoting fatty acid B oxidation and inhibiting lipogenesis through blocking the mTOR pathway NCOR1 TG CYP4A11 NR1C1 ACOX1 FASN PMC8730700__F3 Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location CXCL1 CCL11 HGF CXCL9 CXCL8 IL2RA CXCL12 PMC3263550__F2 Parkinson's disease pathway from the KEGG disease database TH SNCA STX1A SNCAIP PTEN GPR37 PMC8872267__F1 Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection HIF1A HEL-S-133P PMC4560923__F2 Yeast MAPK signaling pathways are associated to hypersensitivity to cell wall stress conditions FAR1 CDC42 PMC11211258__F1 Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment NLRP3 IRF8 GZMA GSDMC AIM2 GSDMB GSDMD DFNA5 PMC2858442__F3 Model of CD95-mediated signaling HEL-S-62p CS C6 PMC2680672__F2 Regulation mechanisms for Itch-mediated Th2 differentiation.TCR triggering plus CD28-mediated costimulation results in the activation of MEKK1-JNK signaling pathway, which induces the serine/threonine phosphorylation of Itch FYN JUNB NDFIP1 ITCH PMC8289875__F2 Longitudinal genome-wide methylation study of PTSD treatment using prolonged exposure and hydrocortisone TH CACNA1H CREBBP PRKCZ LRP5 PLCE1 DKK1 BDNF PMC7141330__F2 Hepatitis C virus (HCV) sensing by the intracellular innate immunity throughout the virus life cycle TBK1 IRF9 IRF3 TYK2 JAK1 IRF-1 TLR3 MAVS PMC6250284__F1 The nicotinamide adenine dinucleotide (NAD) synthesis pathway NAPRT NAMPT NRK PMC8025242__F3 Metabolism-modulating activity of IL-17 signaling in health and disease KLF15 UCP1 IL33 KLF2 KLF3 PMC4513933__F2 Summary of the interactions between the PI3K/AKT pathway and RUNX2 with integration of the TGFB pathway MMP14 IHH MMP2 RUNX2 SMURF2 MMP9 GSK3B SNAI2 PTEN SOX9 PMC6331066__F7 Model for EBV related chemoresistance.Notes: EBV activates the ATR-mediated DDR pathway, which is characterized by enhanced phosphorylation of the pathway proteins RPA32, CHK1, and H2AX RAD51 ATR H2AX PMC3013518__F1 Vitamin D3 biotransformation pathway CYP27A1 CYP2R1 CYP24A1 CYP27B1 PMC2930854__F10 Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development PI3 CDC42 PMC4694682__F5 Polyphenols activate Keap1/Nrf2/ARE pathway and increase the expression of detoxification/antioxidant enzymes.Notes: In the cytoplasm, Keap1 protein is always bound to Nrf2 transcription regulator and prevents its signaling KEAP1 PRX PMC7393270__F8 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs ISG15 SNCA OAS2 OAS3 IKBKG RSAD2 DHX58 STAT2 DNASE2 GBP2 TLR3 PMC7393270__F7 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs FABP2 NR1i1 SCD SLC2A2 CXCL3 PPARG MTTP FABP1 PMC7052940__F1 FGF/FGFR signaling pathway involved in resistance to oncotherapy EGFR CCND1 STAT3 PMC11771116__F3 Putative pathophysiological mechanisms leading to the incidence of amyloid-related imaging abnormalities (ARIAs) in the brains of patients with Alzheimer’s disease (AD) TIMP1 C4B_2 MMP9 C1S APOE PMC4893057__F1 Sequence elements and protein components involved in the formation of poly(A) tails POLE CP POLI PMC8407980__F9 Alterations and Potential Roles of MCMs in Breast Cancer ATM DES PTEN GAL ATR PMC4107319__F8 GIV/Girdin is a central hub for pro-fibrogenic signalling networks during liver fibrosis TLR4 SMAD2 FOXO1 PMC6293652__F7 Mechanism model of PIK3CA E542K and E545K mutation-mediate regulation of proliferation and glucose metabolism via the Beta-catenin/SIRT3 in cervical cancer GSK3B HEL-S-281 SIRT3 PMC8714844__F6 Recent Progress in Lymphangioma VEGFC CS EFNB2 PIK3CA MTOR GLA EPHB4 PMC9255545__F1 Drug targets in the IL-23–IL-17 pathway IL17RA IL17RC IFNG PMC7697104__F1 Coupling of glucose metabolism with insulin secretion in pancreatic Beta-cell SDHC PDK2 FFAR1 SLC25A29 UCP2 MDH2 SLC25A18 SLC25A12 SLC25A22 SLC25A13 FH MPC1 MPC2 OGDH PCK2 SLC25A15 SLC25A1 CD36 PMC7918468__F4 Cellular contributors to tau-dependent degeneration NLRP3 CX3CR1 CX3CL1 PMC8480040__F2 Long non-coding RNA H19 in the development of osteoporosis RUNX2 MSC JAG2 FOXC2 DKK4 PMC11876172__F1 Signaling pathways and associated genes with mutations linked to hyper-IgE syndrome CARD11 BCL10 TGFBR1 DOCK8 TGFBR2 TRAF6 ZNF341 IL6 ERBIN STAT3 TAB3 PMC5928601__F3 Arachidonic acid and linoleic acid metabolism signaling pathways LTA LIF LTB HEL110 PMC10311254__F1 Unlocking the power of precision medicine for pediatric low-grade gliomas: molecular characterization for targeted therapies with enhanced safety and efficacy NF1 TSC1 BRAF PTEN MTOR PMC12104568__F2 CTLA‐4 mediated inhibition in T cells APC LCK CD80 MTOR PMC8366957__F7 Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis GPX3 KEAP1 NQO1 PMC1924866__F6 Striped view of multiple data types PON2 LIPC HRH2 SCARB1 ADRB1 ADRA2C FBP1 APC APOC2 APOC1 ADRB2 HMGCR HRH1 DGAT1 PON3 ADRA1B ADRA2A LPL LDLR ADRA1A ADRA2B ADRB3 APOE PMC8114706__F7 Aging signal of C TSC2 EEF2K TSC1 EEF2 MYC WDR24 EIF4E EIF4B SIRT1 RHEB PMC6826402__F1 Proteomic workflow for the investigation of molecular determinants of acquired resistance to cetuximab RPLP0 SRI SDCBP VASP CSK EGFR S100A2 AHNAK FLNB HEL-S-87p CDCA2 CRK JUP DSG2 RELA ARF4 SRC ATXN2 LSR LPP PXN HEL-S-133P EPHB2 ACTR2 PMC1924866__F5 Striped view of multiple time-point comparisons PTGER2 PTGFR HSD11B1 ANXA3 ANXA4 PTGER3 ANXA6 HEL-S-7 PTGS1 HPGD PTGER1 ANXA2 PTGDR PTGIR PTGIS ANXA1 HSD11B2 PTGS2 PTGER4 CYP11A1 TNF EDN1 EDNRA EDNRB TNFRSF1A PMC10531058__F2 SIRTI 1 pathway SIRT1 FOXO1 PMC10531058__F1 Lnc-RNAs in the Pathogenesis and Development of Diabetic Retinopathy MTOR IRS1 PMC10531058__F4 TGFB pathway BAMBI PMC3429771__F5 Opposing roles of FGF2 and BMP4 in directing TB formation from epiblast type ES cells and iPS cells and the need to exclude FGF2 from the growth medium to minimize the co-induction of mesoderm and endoderm HLA-G BMP2 FGF2 BMP7 BMP4 PMC2230579__F10 Left, the mechanism, described by , for the proapoptotic function of TSP1 or 2 VLDLR VEGFA SRC CD36 PMC10531058__F5 Nuclear factor erythroid 2 related factor 2 (NRF2) pathway SOX2 KEAP1 PMC11928779__F10 One carbon (1C) metabolism MTAP MTR DHFR HEL-S-64p AMD1 pcap CBL PMC6904269__F3 Schematic depiction of downstream mediators of the IL-36 signaling pathway IL36A IL36B MYD88 PMC10215600__F1 Nrf2 and SIRT1 signaling pathways regulation by antioxidants MT3 KEAP1 FOXO3A PTEN SIRT1 PMC3667713__F4 Molecular Rheostat at the Interface of Cancer and Diabetes EGFR IQGAP1 PMC6721565__F1 Canonical WNT signaling RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC6721565__F3 LRP6 and WNT/Beta-catenin pathway alterations in epithelial cancers RNF43 APC LRP6 DKK1 PMC7391798__F2 Autophagy PCR chip and KEGG PATHWAY database analysis MFN1 MFN2 ATF4 AMBRA1 SP1 BNIP3 PGAM5 USP30 OPTN FIS1 NBR1 PMC3484421__F2 The PI3K/Akt/mTOR pathway: Ligands binds to the receptor tyrosine kinases like EGFR, IGF1R, Her2, and Ras leads to conformational changes and activates PI3K BAD IGF1R EGFR GSK3B MDM2 PTEN EIF4E MTOR RHEB PMC11563829__F2 Major downstream events of Trop-2 IGF1R SRC ADAM10 PMC2660380__F3 Lysophosphatidic Acid Signaling in Airway Epithelium: Role in Airway Inflammation and Remodeling EGFR LYN HBEGF LPA PMC10539942__F1 Ferroptosis in effects of anesthetics on multiple organ diseases: A literature review GPX4 LPCAT3 FACL4 KEAP1 STAT3 PMC2886153__F1 Schematic representation of the intracellular cholesterol transport pathway NPC1 NPC2 PMC11505051__F5 Pathogenesis of inflammatory skin disease and aging by PM exposure and associated ROS signaling pathway COX2 IL1A BAD AHR PMAIP1 IL6 LORICRIN TNF BAX PMC11505051__F3 Onset and exacerbation pathogenesis of chronic inflammatory respiratory disease by PM exposure and associated ROS signaling pathway COX2 TJP1 MPO IL13 IL6 CCL2 IL4 IL5 MUC5B IFNG PMC5171696__F1 Anaplastic lymphoma kinase (ALK) signaling: Pathway figure that depicts normal activation of ALK through ligand binding PTN ALK MTOR JUN PMC9166621__F8 Systematic Review and Meta-Analysis of Phytoestrogen Protects Against Myocardial Ischemia/Reperfusion Injury: Pre-Clinical Evidence From Small Animal Studies NLRP3 TLR4 USP19 ARHA BAX PMC4133204__F10 Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NFKB Signaling Pathway MMP2 MMP9 STAT3 PMC4391119__F6 Schematic summary of findings MSTN FOXO1 FOXA2 PMC8589435__F4 Crosstalk between canonical and non-canonical Wnt, Hippo and Notch signalling pathways WNT3A YAP1 ATOH1 FZD7 LRP6 LATS1 RHO DKK1 GPR49 AXIN2 BMP4 HES1 PMC6085667__F5 Compound–target network CCNA2 F10 THBD GSK3B MAPK14 MAOA ALOX5 CCL5 PTGER3 CCL2 HIF1A CDKN2A NQO1 IFNG MMP3 KDR MMP2 LPL HEL-S-44 MAPK1 CHRM2 NOS2 ADRB1 GSTM1 ADRB2 AKR1B1 TNF CALM1 CDKN1A VCAM1 BCL2 NR1C2 F7 MPO COL3A1 ACHE COL1A1 ADAM17 RXRB PIM1 STS ADH1C HEL-S-117 FASN CTPS2 MGAM CYP1B1 WNT16 NR3C2 ARHA ATP2A1 ADH1A GSTM2 ENPP2 ARF5 CD40 PPARG RALA SRC CSF2 VEGFA GRIA2 HEL-S-22 RXRA CDK2 CHRM1 ADRA1A HTR2A MSMO1 CDC42 EGF HGF IFNA1 MAP2K4 ACACA PDE3A EGFR MTOR CYP1A2 CHRM5 TET1 PLAT TLR7 F2 F3 PTPN1 PTPN11 IL2 XDH CDC2 CHPF NR1H3 JUN IL1B SELE PTGS2 IL6 CYP2A6 CHEK1 HEL-S-130P ADRA1B CHRM3 CYP3A4 GJA1 ND1 RELA PMC4091735__F1 Evading apoptosis in cancer BAD BIK BMF HRK BAX BOK PMC6085667__F6 Targets of signaling pathways CCNA2 GSK3B RALA PTGER3 CCL2 HIF1A CDKN2A IFNG MMP3 KDR LPL SRC NOS2 ADRB1 VEGFA ADRB2 TNF CALM1 CDKN1A VCAM1 CDK2 BCL2 ADRA1A EGF IFNA1 HGF COL3A1 ACACA EGFR MTOR CDCA2 COL1A1 CHRM5 RXRB PIM1 TLR7 PTPN11 IL2 CDC2 NR1H3 IL1B JUN SELE FASN PTGS2 ARHA IL6 CHEK1 RELA CD40 PMC7598934__F6 MDA-7/IL-24-mediated inhibition in progression of PC-induced bone metastasis through modulation of the bone microenvironment NFATC1 GSK3B IL24 PMC3155297__F1 General and organelle-specific stress response pathways influenced by the ageing process IGF1 EIF2A HSF1 PMC8712697__F3 Comparative Genomic Analysis of Labrenzia aggregata (Alphaproteobacteria) Strains Isolated From the Mariana Trench: Insights Into the Metabolic Potentials and Biogeochemical Functions NAPB PMC5536000__F5 Schematic of the miR-206 regulatory mechanism during adipogenesis LPL EIF4E HEL-S-104 PMC2700405__F1 The canonical Wnt/Beta-catenin signaling pathway APC GSK3B AXIN1 LRP5 LRP6 PMC9414397__F4 Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities TBK1 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 MAL PMC3136489__F10 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood BTK EGR1 BAD BASH CSK LYN GRB2 UNK PLCG2 PTEN MTOR PMC4431773__F1 Anti-HCV drugs targeting viral life cycle CLDN1 CD81 PMC9045034__F3 Anti-tuberculosis drug candidate pipeline and mechanism of drug action PMC3136489__F11 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood SLA ITK FYN LCK ZAP70 GRB2 TEC SHB BAAT LAT PMC5362574__F8 Suggested model STAT1 SRC TF IFNG PMC4951198__F10 Molecular and physiological defects in mice lacking BRAF and RAF1 in the epidermis IL18 BRAF IL13 IL2 CCL7 IL6 RAF1 IL4 IL5 TSLP PMC9318090__F2 Scheme of molecules and pathways involved in DR and their relationship ANGPTL4 LRP6 ANGPTL8 PMC2840217__F7 Changes in cell cycle regulation in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells NDN ATM CD2 RB1 TOP2A CHEK1 PMC6203794__F1 Tumor-induced CD8+ Treg cells and their potential role in tumor microenvironment CTLA4 FOXP3 PMC2840217__F6 Antioxidant and phase II detoxifying enzyme genes in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells AIP KEAP1 FOS GPT GCK GATA1 BATF MAF H1-2 HEL-S-64p HEL-S-44 EPHA1 IL4 JUN HEL-S-20 MAL PMC2840217__F9 Parkinson's disease (PD)-related gene pathway in response to MG132, methylmercury (MeHg), and cadmium (Cd) in MEF cells SNCA USP26 USP2 BTRC PACRG USP21 ARIH1 INS UBL3 STX1A SNCAIP UBAP1 CASP3 UBE2C UBE2J1 HEL-S-67p CASP9 HEL-117 USP29 ARIH2 GPR37 PMC5412884__F1 Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease EGF NUMB WNT3A DLL4 APC EGFR PTEN GPR49 PMC6254660__F7 Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation PGP MYC PTEN HIF1A MTOR PMC3830525__F4 Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells EGR1 RAB5B KLF5 CDC42 PMC5866434__F2 Effect of CO on cellular inflammation pathways NLRP3 TLR4 PMC2840217__F8 Alteration in Ubiquitin-Proteasome System (UPS) in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells PSCA PMC8465636__F6 Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation ATF4 HEL-75 PSPH ATF3 MTHFD2 PMC11913833__F10 Regulation network by ACS on the innate and adaptive immune systems of young rabbits NLRP3 TLR4 NOD1 APC NOD2 PMC9600461__F3 Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells WNT3 WNT3A HEL-S-11 WNT1 MSC GSK3B CA3 BDNF WNT7B PMC9213082__F8 Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression TLR4 TRAF6 MYD88 AXL SOCS1 PMC4007596__F2 Cytoscape plugin was used to analyze within Balb/c up-regulated genes, genes interaction within the same pathway and across different pathways HTT MAPK1 JUN PMC8743723__F8 Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/Beta-catenin pathway by directly binding to aldolase A MMP7 APC GSK3B CCND1 HEL-S-87p PMC4671322__F1 Molecular mechanisms underlying the oncogenic metabolic phenotype IGF1R EGFR MYC PTEN MTOR PMC4007596__F3 Cytoscape plugin was used to analyse within C57Bl/6 up-regulated genes, genes interaction within the same pathway and across different pathways NDUFC1 MTOR HSD17B10 PMC4530889__F7 Dysregulation of the Transforming Growth Factor B Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia SMAD2 TGFBR1 SMAD4 PMC9687381__F2 Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation EBP XBP1 PMC4214431__F1 Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut TWIST1 ZEB2 PMC5744080__F8 GF1 mechanism of preventing ox-LDL-induced inflammatory injuries through activating A20-mediated NFKB signal pathway IL16 TLR4 APOE PMC3733962__F1 Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2A Expression TP53BP2 RPLP2 DKFZp434N041 UBE2L3 LBR ARHGEF2 HSPD1 CCT4 HEL-S-67p SH3BP4 CKAP2 ACTN4 YWHAG PMC8435533__F7 Schematic figure showing EMP3 signaling pathway EMP3 MTOR YTHDC1 PMC8071327__F1 Sphingolipid metabolism and compartmentalization SET CERT1 PMC4309684__F8 Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization SKP1 NEDD8 FBXW7 PMC8071327__F5 SphK1 and S1P signaling in colorectal carcinogenesis and progression SPHK1 SKI TNF STAT3 PMC5628093__F2 Crosstalk between Panx1 and ligand-gated receptor channels SRC PANX1 PMC4370098__F7 Signalling mechanisms regulating phenotypic changes in breast cancer cells TSC2 TSC1 CSK SRC PTEN ACLY MTOR PMC4466682__F9 EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells EGF EGFR ARF6 PMC5907632__F1 Etirinotecan pegol metabolic pathway CYP3A4 APC UGT1A1 PMC5318911__F7 Identification of miRNA-mRNA Modules in Colorectal Cancer Using Rough Hypercuboid Based Supervised Clustering CASP3 BAD APC MSH6 CASP9 SMAD4 RHO DCC BAX PMC6406581__F3 Mammalian target of rapamycin (mTOR) pathway ULK1 PRR5 DEPTOR PPARG PMC6277783__F2 Schematic representation of various processes during seed filling stage in both monocot (top left) as well as dicot (top right) plants HP SI GPT PMC3721368__F1 Schematic depicting the canonical and noncanonical TGFB signaling systems coupled to EMT in MECs HEL-S-28 SMAD2 SMAD4 SRC ARHA MTOR SMURF1 STAT3 PMC7013724__F3 Mitochondria unfolded protein response (UPRmt) UBL5 ATF4 CLPP PMC2882865__F2 Transcriptional regulation by E2F complexes modulates cell-cycle control, cell fate, and survival SUV39H1 NOTCH1 HDAC1 PMC7899890__F6 Interaction between tumor necrosis factor and tumor necrosis factor receptor 2 signaling CASP3 EDN1 TRADD IL6 TNF FADD MLKL SELE ITCH PMC2692221__F1 BER subpathways for damaged bases and DNA strand breaks OGG1 PCNA MPG PMC2777383__F1 Predictive Phosphorylation Signature of Lung Cancer BAD GJA1 EGFR MYC GRB2 CASP9 SRC MTOR CRK JUN PXN STAT3 PMC10299596__F1 BCR signaling pathway and BTKis resistance in CLL BTK BCR BASH LYN SRC SYK PLCG2 MTOR PMC2906469__F3 Progressive inactivation of GSK3B may promote increased anti-apoptosis and oral cancer GSK3B BCL2 FADD BAX PMC11992733__F6 Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway HEL-S-2a SP1 PMC2906469__F4 Targeting GSK3B pathway may be highly beneficial for curing oral cancer APC EGFR MTOR PMC8355588__F5 Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients ABCG1 ABCA1 PMC8069026__F1 Illustration of the metabolism of galactose through the Leloir pathway PGM2 PGM2L1 HEL-S-19 GAL PMC7501700__F6 AD-integrated pathway and functional modules EGF CHUK TRADD EGFR TRAF6 MTOR PRKCA COX2 TLR4 HEL-S-11 JUN HEL-S-133P BAX VEGFA ENO1 SHE RAC1 EIF4E TNF IRS1 HEL-S-162eP CALM1 PRKCB ERBB2 RELA GRB2 CD40 BDNF TRAF2 CDC42 PMC7406690__F2 Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways TEAD3 TAOK3 VGLL4 TEAD4 LATS1 MOB1A MOBKL1A LATS2 TAOK1 TAOK2 TEAD2 PMC8699889__F8 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer APC TNFSF10 IFNAR2 PNP IFNG PMC8699889__F7 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer GANAB APC PSMB2 DAP NPEPPS CFTR IFNG TAPBPL ATM FURIN ATR PSMB10 BCAP31 PSME2 PMC8699889__F6 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer RAP1A ACACA HMGCL SUCLG1 SUCLG2 XBP1 ACADM ACAT2 PMC8699889__F5 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer WEE1 ATM CDK2 APC SKP1 CDK4 RAN ATR CDC34 SKP2 CP GLS PMC10708062__F10 Analysis of DEGs involved in citrate cycle pathway in roots under osmotic stress HEL-S-26 SDHC CS PC OGDH ACLY HEL-S-32 SDHA MDH2 SDHB PMC3286397__F11 Campylobacter jejuni-induced Cdc42 activation EGFR SRC RHO CDC42 PMC9033871__F3 Inflammation and atherosclerosis: signaling pathways and therapeutic intervention TBK1 IRF7 IRAK1 TRAF3 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 GSDMD NLRP3 PCSK9 LTA TIRAP PMC4364658__F1 MiRNA targeted signaling pathways in four different important cells including plaque macrophage, platelet, monocyte and endothelial cell NGF APC EGFR RHO SKP2 PMC11043956__F7 SSYYJN ameliorates CKD-induced muscle atrophy by inhibiting ferroptosis in tibialis anterior muscle cell via HIF-1A/SLC7A11 pathway GPX4 SLC7A11 SLC3A2 PMC7212757__F1 Role of Excitatory Cerebellar Nucleocortical Circuit in controlling associative motor learning DCN CS PC PMC3461933__F1 Looking in the miR-ror: TGFB–mediated activation of NFKB in glioma NFKBIA EGF SOX2 LIF EGFR ID1 PMC4364658__F6 MiRNA targeted upregulated genes of Rho GTPase signaling ARHGEF18 RHOBTB1 ARHGEF4 ARHGEF7 ARHGAP30 ARHGEF12 ARHA SRGAP3 RHO PLEKHG5 RHOU ARHGEF11 DEPDC1 HEL159 KALRN FGD2 RHOF ARHGAP29 ARHGAP5 RHOB TSN PMC3533285__F11 SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation TWIST1 CXCL2 GPS2 PMC3434350__F1 Translational impact of the mTOR signaling pathway CD44 HEL113 EIF4E RPS6 EIF4G1 PMC8699889__F9 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer CENPB CDC20 KNTC2 MADD APC INCENP CENPC NSL1 PMC3759360__F2 When Ubiquitin Meets NFKB: A trove for anti-cancer drug development ATM TRAF3 LTB RELB TRAF6 PARP1 POLI PMC8093449__F2 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention ChAT KCNN2 ACHE PMC9361019__F6 Stemness Analysis Uncovers That The Peroxisome Proliferator-Activated Receptor Signaling Pathway Can Mediate Fatty Acid Homeostasis In Sorafenib-Resistant Hepatocellular Carcinoma Cells RXRB CYP8B1 SCD NR1H3 TF PMC3953890__F1 EGFR-axis pathway that contributes to cyst formation and progressive enlargement in ADPKD and ARPKD GRB2 HBEGF TGFA PMC9266896__F1 Interleukin 15 in Cell-Based Cancer Immunotherapy IL15RA JAK3 JAK1 STAT3 PMC4272425__F9 Proposed model of Pofut1 involvement in commitment of myogenically differentiated cells through activation of the Notch signaling pathway POFUT1 PAX7 PMC7912342__F6 CGAS-STING signaling pathway CGAS IRF3 PMC6090282__F13 Signaling pathways activated by temozolomide in glioma cells TRPC1 FOS SRC MTOR JUN PMC6331329__F5 InterferonG regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells CCND1 HDAC2 CDK4 PMC7912342__F5 NLRP3 Inflammasomes signaling pathway NLRP3 CGAS P2RX7 IL1B PMC7912342__F4 RLR signaling pathway IRF7 TRAF3 IRF3 FADD PMC8093449__F5 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention CACNA1B BRAF SLC32A1 MAPK3 CREB1 ACHE SNAP25 GAD1 TRPV1 GNAI1 KCNJ3 KCNA1 KCNJ14 GABBR2 GABBR1 CAMK4 SLC18A2 TRPV2 KCNJ6 SRC KCNJ5 PMC3845018__F3 Graft-versus-host disease signaling pathway and miRNA interactions obtained using IPA HGF CXCL10 TRAF6 TNF PMC7912342__F1 Toll-like receptor (TLR) dependent signaling pathways TBK1 TLR9 TRADD IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR10 TLR3 TLR8 TLR7 TLR4 TAB3 MAL PMC4364457__F3 MicroRNAs Are Part of the Regulatory Network that Controls EGF Induced Apoptosis, Including Elements of the JAK/STAT Pathway, in A431 Cells CCT6A TCP1 HEL32 CAP1 HEL-S-15 BANF1 EZR TUBA1B PS1TP5BP1 HEL-S-69p PMC8233862__F4 Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis IGF1 MSC MTOR PMC4386978__F1 Extracellular signalling molecules in the ischaemic/reperfused heart – druggable and translatable for cardioprotection? GSK3B PGC STAT3 PMC6456305__F6 GPs unmask cryptic variation in parallel signaling pathways and subpathways SF1 NRG1 PMC9684800__F4 Roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors BMP10 IRAK1 APC SRC MTOR ID1 SMAD1 EPHB4 DKFZp781O1323 PMC3749846__F3 Role of DMP1 and its future in lung cancer diagnostics MYC CCND1 CDK4 DMP1 JUN PMC8790423__F2 Statin as a therapeutic agent in gastroenterological cancer ERG ARHA PMC9101507__F4 Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond RAB35 EGF EGFR PMC8790423__F1 Statin as a therapeutic agent in gastroenterological cancer LDLR HMGCS1 HMGCR FASN PMC6986441__F1 Canonical pathway (Modified from IPA) for Opioid Signaling [−log(P-value) = 8.48; Z-score = 0.392] ADAR BAD BRAF SLC12A5 FOS GSK3B MYC FOSB PMC9559516__F5 RKIP in the Regulation of EMT in the Tumor Microenvironment EPCAM ARHA NECTIN1 PMC6986441__F3 Canonical pathway (Modified from IPA) for Dopamine Receptor Signaling [−log(P-value) = 2.97; Z-score = 1.89] SCG5 PTH LAG3 CHRM4 LEP PTPRN POMC CHRM1 GDNF OPRK1 CARTPT MDK CALY PMC4441763__F4 Quantifying Ubiquitin Signaling PINK1 MFN2 USP2 USP21 OTULIN PMC6986441__F2 Canonical pathway (Modified from IPA) for Corticotropin Releasing Hormone Signaling [−log(P-value) = 3.74; Z-score = 1.29] TH PRKCE SCARB1 ATF2 UCN PRLHR COX2 POMC CRH KCNK9 SHH CARTPT NPY2R GAL JUN KRT1 ADM PMC8303227__F1 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target PALB2 BLM WRN BACH1 APLF FEN1 POLE ATM MSH6 RAD52 MSH3 MSH2 RTEL1 SLX4 EME1 XPC BARD1 SSB DDB2 LIG1 BRCA1 PAXX PMS2 BRCA2 ERCC1 ATR PNKP PMC3279943__F1 PI3K and STAT3: a New Alliance TSC2 RHEB STAT3 PMC7601167__F1 Graphical abstract depicting the mechanisms of inherent and acquired resistance to PI3K inhibition at different vertical nodes along the PI3K/Akt/mTOR pathway PIK3CA CCND1 CDK4 MTOR CDK6 PMC4936558__F6 Genes up- and downstream of flavonol biosynthesis are also affected in the Δy mutants MYB CCR2 GSTZ1 CCR3 PMC11721291__F7 CGAS/STING activity CGAS TREX1 IRF3 PMC4113246__F3 Gene Regulatory Networks in Cardiac Conduction System Development SHOX2 PITX2 TBX3 TBX5 HCN4 PMC6986441__F5 Canonical pathway (Modified from IPA) for GABA Receptor Signaling [−log(P-value) = 5.07; Z-score = NaN] UBQLN1 ABAT SLC32A1 GABRQ GABARAP GPHN GABRA4 ALDH9A1 PMC8557524__F3 Targeting CD47 for cancer immunotherapy SIRPA CD47 WAS PMC9316483__F2 Study on the Molecular Mechanism of High Altitude Heart Disease in Children EDNRA EP300 ANGPTL4 PTEN NR1C1 EGLN1 HIF1AN PMC6986441__F4 Canonical pathway (Modified from IPA) for Serotonin Signaling [−log(P-value) = 2.04; Z-score = NaN] SPR DDC PMC1936363__F1 Epidermal growth factor receptor pathway BAD PDK2 GSK3B CCND1 PTEN MTOR PMC8481641__F2 Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes SIRPA CD47 ZAP70 HEL-S-92n PRF1 BNIP3 IFNG PMC5422340__F4 TGFB1-mediated regulatory network via Ingenuity pathway analysis RARA NFKBIA CEBPE NFKB1 RELA INS SP1 STAT3 PMC6637653__F7 Breast cancer cell-based pathobiochemical pathways showing LPHN-induced activation of PKCA, which triggers the translocation of Tim-3 and galectin-9 onto the cell surface which is required for immune escape GIP FLRT3 PMC5422340__F3 P53-mediated regulatory network via Ingenuity pathway analysis CEBPD NFKBIA FOXO3A ERBB2 FOS RELA NR3C1 SP1 TNF JUN CEBPB STAT3 PMC8660623__F8 Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway RUNX2 VWF MTOR SMAD1 DKFZp781O1323 PMC4619170__F7 Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude RP2 ATR PMC8303227__F4 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target RAD1 PALB2 BRIP1 MDC1 BARD1 SSB RCC2 MRE11A BRCA1 ATM BRCA2 CDK2 TOPBP1 MSH6 RAD50 RAD52 RAD51 CDC2 ATR CP PMC5988934__F1 Activation of antiviral innate immunity in CHB TLR8 PDC TLR7 TLR9 IRF7 IRF3 MYD88 PMC1176468__F9 Crosstalk model of ATF3 and c-myc in serum induction ATF2 SRC ATF3 PMC7588667__F4 DNA damage response in amyotrophic lateral sclerosis RNF168 RBM45 RNF8 ATM SQSTM1 ATXN2 PARP1 VCP FUS HDAC1 PMC4782221__F5 SYK tyrosine kinase: a crucial player in diverse biological functions HEL-S-11 OSCAR SYK PLCG2 PMC5192357__F1 Action of blockade of inhibitory pathways or activation of costimulatory pathways to promote CD8+T cell priming after vaccination TNLG8A CD40 CTLA4 FOXP3 PMC10136857__F1 Canonical and non-canonical Wnt signaling pathways in cholangiocytes and the role of the primary cilia in modulating these pathways APC LRP5 LRP6 ARHA RAC1 PMC10534279__F4 Growth differentiation factor 15 in cancer cachexia (Review) MAP3K11 SMAD2 TGFBR1 SMAD4 CCL2 RET POMC NPY GDF15 CRH GC GFRAL STAT3 BAX PMC10534279__F3 Growth differentiation factor 15 in cancer cachexia (Review) RET GDF15 ERBB2 SMAD2 SMAD4 MTOR GFRAL SMAD1 DKFZp781O1323 PMC11528463__F7 BC-derived CAV1 promoting BC lung metastasis NLRP3 TLR4 MMP9 SRC SFTPC CCL2 PMC5733215__F4 STAT3/S1P/S1PR1/SPHK1/SPL-positive feed-forward loop promoting CAC CYLD S1PR1 SPHK1 PTEN SPNS2 STAT3 PMC8909868__F3 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma SMAD2 TRPC6 STAT3 PMC3581520__F1 Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis PC LPCAT3 CHKA LPCAT4 CHKB LPCAT2 LPCAT1 PEMT PMC8909868__F2 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma MMP2 KEAP1 MDM2 NOTCH1 CDH2 BAX SIRT3 PMC12066790__F9 Oncogenic mechanisms of EBV in lymphoma NFKBIA TAP2 NRF1 DPP4 CCL20 GABPA WAS HEL-117 TIGIT OGG1 PMC12066790__F6 Oncogenic mechanisms of HPV in cervical cancer EGF CGAS E2F4 EGFR CCL21 MYC CCL5 WAS CCL2 HIF1A COX2 ATR HEL-S-133P FADD TERT PMC9323628__F3 Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis USP12 USP26 USP16 USP19 FOXM1 USP14 EGFR MYC HEL-117 USP11 USP22 BAP1 PMC12066790__F5 Oncogenic mechanisms of EBV in gastric cancer GCNT3 BAD IHH IGF1R PBRM1 MMP9 APC VEGFA VHL PTEN DKK1 LAG3 WTAP CXXC4 MMP2 KHSRP PIK3CA THBS1 CCL22 STAT3 PMC6396132__F3 Hedgehog signaling and Wnt signaling in the primary cilium FZD3 PTCH1 SMO PMC7825432__F3 Glycolysis reactions and the reactions of encapsulated enzymes (GDH + AAT) in erythrocyte DAP HEL-S-162eP PMC12066790__F7 Oncogenic mechanisms of EBV in nasopharyngeal carcinoma GPX4 BAD KEAP1 SLC7A11 SMAD2 EGFR ANXA3 TGFBR2 SMAD4 MTOR CDKN2A AHR FH ATR CCL22 TNFAIP3 HEL-S-133P ROS1 HK2 GLUD1 STAT3 PMC12066790__F4 Oncogenic mechanisms of HBV and HCV in hepatocellular carcinoma HMGB1 AFP EGFR GCK CTLA4 SMC5 CDK2 SMC6 TXNIP TGFB1 HK2 STAT3 TERT PMC8705881__F1 MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma MMP9 EGFR MDM2 GRB2 CDK4 PTEN MTOR SLC31A1 CDK6 STAT3 PMC7820019__F8 Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24 TSC2 TSC1 MTOR PMC3328827__F2 Beyond inactivation of the MEN1 gene, additional mutations in other genes may be responsible for acceleration of tumor growth, thus involving a process of multistep tumorigenesis FOS MYC CCND1 PTEN RAF1 MTOR JUN PMC7334796__F6 Distribution of partial targets of ATR and CR on the compressed pathway CHUK TRADD GSK3B VEGFA INS TRAF6 ADRB2 TNF INSR RXRA IKBKB PLN CASP3 KDR CHRM3 GRB2 BCL2 JUND CHRM2 FLT3 HTR2A ATR PMC3851046__F7 Proposed molecular mechanism for the inhibitory effects of zinc on RANKL-induced osteoclastogenesis NFATC1 OSCAR TRAF6 SYK ORAI1 SIRPB1 PMC11173094__F3 Natural products that modulate specific proteins in the molecular pathway of inducing and inhibiting ferroptosis GPX4 LPCAT3 FACL4 SLC7A11 DPP4 ALOX15 ALOX12 AIFM1 MAP1LC3A TFRC HIF1A POR HMOX1 TXN DKFZp686F0183 AIFM2 ATF4 SP1 HILPDA ALOXE3 YAP1 FTH1 GCLC FTMT NFE2L2 FTL ATF3 HEL110 WWTR1 DKFZp762B153 NEDD4 HEL-S-64p TFAP2C HEL-75 IREB2 SLC3A2 SLC40A1 SLC11A2 CP TF PMC3383648__F1 Vismodegib HHIP PTCH2 SUFU PTCH1 GLI3 SMO PMC5795664__F4 Mutations in various genes in the JAK/STAT pathway (MPL, CRLF2, JAK1, JAK3, JAK2, LNK, SOCS1, STAT3) implicated in hematologic malignancies CRLF2 JAK3 JAK1 MPL SOCS1 STAT3 PMC5893443__F8 Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis LRP5 LRP6 PMC9326561__F4 Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells SPARC CLTA PPP4R2 ACOT13 C1QBP HEL-S-84 SMAD2 CHD4 NACA LARP4B ZNF326 PDPK1 PPWD1 MRPS22 RPL12 NOLC1 GNPTG PC COL12A1 TMSB10 SERPING1 SNW1 HNRNPA2B1 DKC1 PPP6C IRF2BP2 HK2 LYAR ANGPTL4 PBDC1 ERH ENG PSAP COL5A2 HEL60 PPP3R1 NUFIP2 TXN2 PPM1F ENO2 PWP1 CAPRIN1 CA12 ZFR CXCL1 PTMS TPM1 COL3A1 NAT10 TFRC COL1A1 GRSF1 ARHGAP1 HEL-S-108 RBM27 SYAP1 MRPL53 MRPL50 TCEAL4 COL1A2 SLIRP MICALL2 HMGN1 SNF8 TBL2 CTPS2 DCTN4 CLTB ME1 PTGFRN YBX1 FTH1 EHD2 BASP1 MRPS18A PCCB TMED10 PSMD3 BET1 LMAN2 UQCRH HEL-S-115 APRT HEL-S-29 COL4A2 SUPT16H TSPAN4 PMC9316001__F2 Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review SCT EGFR CDK4 CDH2 MTOR RXRA STAT3 PMC3399091__F1 PAK1 Molecular Pathway PAK1 BAD FLNA CDK5 PCBP1 RAF1 ARPC1B PMC5108321__F9 The working model of AMDE-1-induced canonical and noncanonical LC3 lipidation GCA ULK1 ATG12 WIPI2 ATG10 DKFZp686F0183 PMC4842122__F1 Signaling pathways involved in SSc pathogenesis that may also play a role in EndoMT SMAD2 PTCH1 SHH SMAD4 NOTCH1 SMO HIF1A PMC8302073__F1 Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells ATM BLM SMC6 RAD51 SPAG4 SMC5 PMC2494567__F10 Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure EGFR TGFA GET1 PMC8490739__F7 SMYD3/ITGB6/TGFB1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids SMYD3 ITGB6 CDH2 TGFB1 PMC8194669__F2 Karyopherin abnormalities in neurodegenerative proteinopathies RCC1 RAN PMC8716696__F4 Impact of Rubella Virus Infection on a Secondary Inflammatory Response in Polarized Human Macrophages STAT1 STAT2 IRF3 TYK2 MYD88 JAK1 TIRAP PMC6110909__F1 Direct and indirect mechanisms of action of metformin in cancer cells TSC2 TSC1 MTOR RHEB SLC22A1 PMC4547205__F2 Ingenuity pathway analysis comparing gingivitis to healthy subjects NRF1 PPARGC1A TRIB3 INS FOXC2 PPARGC1B NR2A2 PMC8657018__F1 Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma IKZF1 SLAMF7 JAK1 STAT3 PMC9324879__F8 New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition COX2 COX1 EGFR PMC3573709__F3 Protein-protein interaction network of NFY and associated genes NASP MYC MSH2 UNG PMC2637758__F5 Pathways and networks associated with HSPA9, PHB, and ABCB6 ENTPD2 SMARCA4 KLK3 IL6 RB1 TGFB1 HDAC1 STAT3 PMC8996962__F2 Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer TRADD TRAF3 CD40 TRAF2 PMC11749133__F4 Immune responses by bufalin in cancer therapy SLC7A11 REL NOD2 CAMKK2 PMC11749133__F3 Astragalus-mediated inhibition of tumor growth EREG RAB27A KLF2 PMC11749133__F2 Impact of traditional Chinese herbal preparations on cancer pathways TLR4 MYD88 TNF JUN PMC6966574__F4 Summary of deregulated genes within different glucose metabolism related pathways and the potential use of certain genes as independent predictors for OS and /or RFS ENPP1 PCK1 DERA PFKFB4 PYGB PC SLC2A2 F2 SLC2A9 GLYCTK RBKS SLC16A4 PCK2 PFKP SDHD ALDH9A1 ALDOB ENO3 HK3 ENO1 HEL-S-87p PDK4 HEL-S-162eP GYS2 HEL-S-41 LDHD IDNK OGDHL SLC16A2 ACLY HEL107 PYGL AGL ALDH2 PMC7692959__F3 XIAP Signaling Pathways in Human Cancer MMP2 EGFR SP1 MAP3K7IP1 FUS PMC5831762__F2 Simple diagrammatic representation of the (known) key events in Shh signaling at the primary cilium BOC KIF7 SUFU PTCH1 GPR161 GLI3 GSK3B EVC SHH SMO GAS1 PMC6895808__F1 Progression of thyroid cancer and the main genetic alterations involved in such process RET BRAF PTEN PPARG TERT PAX8 PMC6433817__F4 Some possible interactions between fungal cell regulatory hierarchies that could respond to oxidants and chemical stresses GPX3 YAP1 ATF1 PMC7878386__F1 Leptin receptor isoforms and intracellular signaling SOCS3 GRB2 IRS1 STAT3 PMC8285540__F7 Model depicting the role of FBXO32 in the crosstalk between CHOP-dependent apoptosis and autophagy CASP3 LAMP2 ATF2 BCL2 PMC6411369__F7 Molecular mechanism of miR-194-5p in HPC involves the mTOR signaling pathway by targeting SMURF1 MTOR SMURF1 PCNA PMC7980524__F1 Structural and functional understanding of the toll‐like receptors TBK1 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 MAL PMC4755870__F5 MicroRNA variants as genetic determinants of bone mass RUNX2 APC SFRP1 HOXA10 PMC8393865__F3 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear USP4 USP15 SMAD2 SMAD4 TRAF6 WWP1 USP11 USP18 TTC3 CYLD USP9X PJA1 RNF111 FBXO30 MAP3K7 SMAD6 TRIM62 NEDD4 SMAD9 RLIM TRIM63 STUB1 COPS5 SMURF2 TNFAIP3 SMAD1 TRAF4 ITCH PMC8393865__F2 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear BAMBI STK17B SMAD2 MAPK14 SMAD4 RANBP9 MMP2 HGS BMP5 SP1 SKI TFAM ZFYVE9 YAP1 KCP MAP3K7 VEPH1 GDF10 EDN1 BCL2 YY1 ERBIN TGFB1 ACVRL1 COL3A1 TGFBR1 TGFBR2 MSX1 GDF1 MAP2K3 RGMB COL1A1 SIK1 FKBP1A PPARGC1A ZFYVE16 THBS1 PPP2R2A TWSG1 GDF5 MGP gdf7 ACVR1 RGS4 BMP2 BMPER SOSTDC1 MAP3K7IP1 GIG8 KAT2A TRIM63 NBL1 SP3 CTDNEP1 SPARC ID4 PPM2C TRAF6 MTMR4 CTGF DCN BMPR2 ACVR2B ACVR2A COL6A1 ROR2 STRAP TGFBR3 CHRDL1 MYOG BMP6 ATF3 ENG COL5A2 MMP14 TIMP1 CDKN2B TGFBRAP1 ACVR1B TMEPAI MEF2C SIRT1 RUNX2 KLF10 ZCCHC12 BMP4 FST CD109 NOG GREM1 COL14A1 HOXC8 COL1A2 FBXO30 HMGB1 KAT2B MEF2B SKIL PRKAA2 SMAD6 BMP7 MSTN ID1 ID3 PPM1H SMAD9 ADAMTS4 MYF5 MUSK BMPR1A TOB1 RGMA GDF11 SMAD1 INHBB INHBA DKFZp781O1323 TRAF4 PMC3074954__F1 ROS have different origins FEN1 SSB PARP1 APTX PNKP PCNA PMC8623825__F1 Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections KEAP1 HEL-S-44 PMC8655846__F2 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants MYB ERF CBL PMC8655846__F1 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants FER PC NCL HEL-S-11 TF CBL PMC7037725__F1 Molecular mechanisms underlying GOLPH3 function in human cancer EGFR RAB1B PITPNC1 GOLPH3 MAJN ARHA MTOR STAT3 PMC7673857__F1 Main source of ROS and redox reaction NOX4 PMC3317213__F4 Metabolism of xenobiotics by cytochrome P450 pathway, and ribosome map views of identified proteins SI LPO PMC9287557__F3 One carbon metabolism MTHFD2L SLC25A38 SHMT1 DHFR SFXN1 TYMS MTHFD1 HEL-S-51e MTHFD2 MTHFD1L PMC4698510__F1 Molecular mechanisms of alcohol-related liver pathogenesis and therapeutic targets ADIPOR1 IRF3 IL6 TG CYP2E1 SIRT1 PMC8850794__F2 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles CASP3 FOXO4 GSK3B CXCL8 PIK3CA BCL2 ARHA PTEN CXCL12 CDH2 BAX PMC9284214__F1 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections IRF3 COMP GAST PMC8850794__F1 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles MDM2 PTEN MTOR FOXO1 PMC4629436__F1 Representative HIF-1A regulatory genes and their effects on cancer progression LEP GIG8 EPO HEL-S-30 IGFBP1 IGF2 IGFBP2 TGFA HEL-S-133P ADM HK2 PMC9284214__F2 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections TBK1 CGAS TRIM9 IRF7 CSK TRAF6 IRF3 ZCCHC3 OTUD5 PMC5968093__F1 Antibodies that target leukemic stem cells (LSCs) and blasts directly CD27 TNIK CD33 TNLG8A TRAF2 PMC4629436__F3 Regulation of HIF-1A pathway at different levels MDM2 VHL MTOR PMC5094977__F7 Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines CASP3 BCL2 BCL2L1 IL6 PTEN RB1 TNF SHC1 IFNG BAX PMC8576385__F3 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout BAD CAST MYLK MAL PMC8371910__F2 Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease IL33 CD80 CTLA4 ICOS IFNG PMC6189061__F5 Proposed model of irisin effects on pancreatic cancer PC CCND1 MTOR PMC4594598__F2 RhoGEF signaling pathways involved in 3D migration NEDD9 SRC DOCK10 ARHA BMI1 NET1 DOCK3 RAC1 LPA ARHGAP22 CDC42 PMC10343815__F5 Differentially expressed genes in the cAMP metabolic pathway suggested that upregulated genes were dominant in this pathway GHRL SST BAD AMH NPY GIP OXT VIP CFTR PMC5909795__F1 Regulation of the core components of the Hippo signaling pathway.Abbreviation: ER, estrogen receptor TEAD3 VGLL4 TEAD4 LATS1 RHO LATS2 TEAD2 PMC8057882__F10 Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation FOXO3A H2AX BAX PMC3371699__F4 miR-519d, miR-190, and miR-340 in the TGFB signaling pathway NOG DCN BMP2 MYC SMAD4 CHAD SKP1 ARHA PMC4138699__F7 GAi-mediated activation of the PI3K-Akt-mTORC1 pathway in response to EGF EGF GSK3B PMC2954312__F2 Crosstalk between the three distinct oscillators that function in the mouse PSM.(a) Schematic diagram of a signalling and a responding cell in the mouse PSM, detailing cyclic genes of the Notch, Fgf and Wnt pathways DUSP4 LEF1 FGFR1 WNT3A APC LFNG NRARP HES7 AXIN2 TF SPRY2 NKD1 PMC5909795__F2 The Hippo pathway regulates organ metastases by controlling cell proliferation, EMT, and immune evasion.Abbreviation: EMT, epithelial–mesenchymal transition LATS1 LATS2 PMC7547073__F2 MicroRNA-34a targets the colorectal cancer pathway BAD FOS TGFBR2 MYC SMAD4 CASP3 LEF1 MAP2K1 CASP9 PIK3CA CCND1 BCL2 AXIN2 DCC JUN ARAF CYCS PMC7962413__F2 Tick signaling-related genes in the three main immune signaling pathways of arthropods: (A) Toll, (B) IMD, and (C) JAK/STAT CACTIN ECSIT FADD PMC6160419__F5 Extracellular matrix organization pathway genes in COPD disease network module FBN2 PRSS1 IHH CHRNA7 BMP2 MMP9 MMP11 FBN1 ENG VASN NID2 CTSG MMP7 ADAMTS4 MMP12 SPINK5 FAM13A STC2 ELANE MFAP2 pp6425 DPT CHRNB2 PMC6066232__F1 Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies PFAS ADSL PAICS HEL-S-70p PMC7024605__F2 Metabolic Immunomodulation of Macrophage Functional Plasticity in Non-Healing Wounds IL16 TLR4 AASS IL1B PMC9264807__F2 SLC7A11 in Cancer: Friend or Foe? UFM1 PRC1 KEAP1 SLC7A11 ATF4 CD44 KDM3B SLC3A2 IRS1 PMC9264807__F1 SLC7A11 in Cancer: Friend or Foe? GPX4 SLC7A11 IFNG GLS PMC6899468__F5 Schematic diagram showing the PST inhibition of gluconeogenesis in hepatocytes PLCB3 PCK1 GC IRS1 PMC9147666__F2 Therapeutic Strategies for Ovarian Cancer in Point of HGF/c-MET Targeting HGF GRB2 RAC1 MTOR STAT3 PMC6899468__F4 Schematic diagram showing the putative signaling pathways for the anti‐inflammatory actions of CST NLRP3 TRADD TNF TRAF2 PMC7880341__F5 NSCLC-pathway COX2 LTA MEI1 TRADD CASP9 RAC1 RAF1 CSA2 TNF PMC6899468__F2 Schematic diagram showing the inhibition of catecholamine secretion and regulation of cardiovascular functions by CST NTS CGA PMC11003275__F1 Schematic chart for molecular mechanisms of metabolic dysregulation in DCM CPT2 CD36 PMC2678244__F1 Abl Tyrosine Kinases in T-cell signaling PLCG1 ITK APC LCK VAV1 ZAP70 RAC1 DOCK2 PMC9293612__F2 Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma SIRPA CD47 CCR2 CCR6 CCL15 CXCR4 CCL20 CCL17 CCL2 CXCL12 STAT3 CD24 PMC7583966__F3 Interferons after ligating to type II receptors activate JAK/STAT pathway resulting in foam cells formation leading directly to atherosclerosis development STAT1 IL24 JAK1 ABCA1 PMC12229470__F6 Molecular mechanism by which AloAB suppresses HNSCC progression via inhibition of the STAT3/SLC7A11 signaling FACL4 SLC7A11 LPO CDH2 STAT3 PMC10300995__F2 Altered amino acid metabolism and potential drugs in DLBCL MYC SIRT3 GLS PMC9363460__F2 Key steps of the mevalonate (MVA) pathway leading to sterol and non-sterol isoprenoid synthesis CH25H FDPS LDLR CYP11A1 ACLY HMGCR PMC10300995__F4 Influence of altered tumor metabolism on immune cells SUCNR1 ARG1 PMC9363460__F1 Non-exhaustive representation of lipid metabolic pathways addressed in the review CPT2 ACLY CD36 PMC10300995__F3 Altered fatty acid metabolism and potential drugs in DLBCL PTEN ACLY MTOR FASN CD36 PMC9363460__F3 Non-exhaustive scheme of lipid exchanges between tumor cells and tumor microenvironment (TME) cells and lipid reprogramming of stromal cells, that activate their pro-tumoral features ABCG1 LDLR HBEGF LPA ABCA1 APOE CD36 PMC6361534__F1 Complement cascade and its regulators HEL-S-62p CD59 C9 C4B_2 C6 PMC6488628__F4 The cellular functions of the PLAC8 up-regulated genes DGIC MLH3 CPA2 PMC7882000__F1 De novo synthesis and regulation of cholesterol ACAT1 DHCR7 DHCR24 CYP7A1 PMC3544567__F2 Differentially expressed genes within the Wnt Signalling pathway APC SKP1 ARHA PMC6361534__F3 Mechanisms through which complement modulates T cell-mediated rejection HEL-S-62p C5AR1 APC C5AR2 C3AR1 FOXP3 PMC12210318__F2 Complete RNM for the MAPK Cancer Cell Fate Network of Grieco et al MAX EGFR MYC FGFR3 PMC6070710__F11 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response CHUK BAD MYC TRAF3 BCL2L1 CASP2 BNIPL TNFSF6 APAF1 MDM2 JUN MAP3K1 MAPK10 TNF DIABLO TNFRSF25 BIRC2 NFKBIA NFKBIB NFKB1 RELA PMAIP1 TRAF1 BCL2 CRADD TNFRSF10B TRAF2 FADD CYCS NFKBIE HRK BOK PMC7415428__F12 Schematically drawing the diagraph for illustrating the signaling pathway and pointing the action sites of melatonin PTEN PARP4 BAX PMC6070710__F10 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response CCNA2 HDAC3 E2F6 PLK1 HEL-S-1 GSK3B SMAD4 E2F3 SMC1A MDM2 HDAC2 MCM10 MCM9 ORC6 APC E2F5 CDC45 MCM3 MCM5 CDC20 MCM6 MCM2 CDC6 ATR TGFB1 PCNA HEL2 CCNH ORC2 CCND2 ATM E2F2 CCNB1 CDC2 PRKDC PTTG1 RBL1 CCNE2 UBE2F HDAC7 ARF1 HDAC1 PTTG2 EP300 BUB1B CCNB2 HEL-S-93 SKP2 ESPL1 PMC2933206__F7 Hypothetical model of how Str1 may affect cellular behavior via the Beta-catenin/LEF signal transduction pathway APC CCND1 PMC8794658__F8 Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis MADD TRO APP CD40 TIRAP PMC1828075__F2 Diagram showing several factors involved in lens development FOXE3 SIX3 BMP7 PROX1 BMP4 PMC9182402__F5 Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin PLK1 FOXM1 SPC24 CENPF DNAJB1 DKK1 ERCC6L SELL GADD45B POLE2 E2F2 JUN SPC25 EGR1 GADD45G TUBB ATF3 DDIT3 AURKB MAFA CLSPN UBE2C BUB1B BTG1 ZWINT CENPU BDNF PMC7775424__F5 Hypothetical contribution of exRNA to virus infection and subsequent cardiovascular disease RNASE1 NRP1 ACE2 PMC10888344__F9 Molecular mechanism that drives the positive impact of CSE in OVA-induced AR mouse model MBP IL33 TNF PMC8147868__F2 Epigenetics of Hepatic Insulin Resistance USF1 HDAC3 PROX1 IRS1 FOXO1 PHF2 INSR JMJD1C IGF1 HNF4A IGFBP2 GRB10 SIRT1 TFAM PMC11314049__F5 Schematic illustration of reactive oxygen species (ROS)-mediated activation of various cell signaling pathways in the skin ATF2 BCL2 PMC7801517__F7 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway S1PR2 GEM BCL2 BAX PMC7716140__F1 Figure shows the pharmacological effects of ulinastatin TLR4 MYD88 BAX PMC7732991__F7 OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression OXER1 PMC5759779__F3 Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease COX1 IGF1 PLD2 PMC4652780__F6 Network overview of the biomarkers in lung cancer and ALL RAPGEF1 EHMT1 DDR1 CPSF6 REM2 ACACA PIM2 VCAN PAXIP1 HEL-S-99n PSMB2 CD79B CANX MAPK13 POLE PEX2 BCL2 ILF3 HEL-S-70p UTP20 CD36 LCT PMC8278085__F7 PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin‐II by reducing TGF‐B1/Smads pathway activation SMAD2 DDR2 TNLG7C PMC5348352__F5 miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival MMP9 PTEN CDH2 HEL-S-93 PMC7461028__F6 PI3K-Akt signaling pathway is downregulated in U87 glioblastoma cells overexpressing ZNF554 BAD MYC PTEN MTOR CCND3 OSMR INSR BCR MDM2 CCND1 THBS1 EIF4B RBL2 CD19 CCNE2 PPP2R5A CDC37 RAC1 EIF4E IRS1 LAMA3 BRCA1 RHEB RXRA ANGPT1 TSC2 LAMA1 NTF3 TSC1 PDGFC RPS6KB2 PPP2R5C GRB2 SYK HEL-S-93 BDNF PMC3875894__F3 mTOR signaling pathway (#hsa04150) TSC2 RICTOR TSC1 HOXA9 BRAF EIF4E MTOR EIF4B RHEB PMC4219921__F1 Steroid hormone synthesis pathways in the adrenal gland and testis STS CYP11A1 HSD3B2 CYB CYP17A1 STAR CYP11B2 PMC3875894__F1 Pathway Protection Loop RICTOR TSC1 PMC9456549__F2 Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects TSC2 PTEN MTOR PMC4061877__F4 Hypothetical outcomes for demyelinated axon.Denuded axon impermissive for myelination MOG LINGO1 TGFBI PMC3509687__F1 Impact of the cellular restriction factor APOBEC3 (A3) on human immunodeficiency virus-1 (HIV-1) replication ULBP2 ATM ATR PMC3875894__F4 Antigen processing and presentation (APP) pathway (#hsa04612) CANX B2M IFNG TAPBP PMC4219921__F2 Classical and non-classical pathways of androgen biosynthesis HSD3B1 AKR1C1 CYP11A1 CYP7B1 UGT2B17 HSD17B2 RDH5 AKR1C2 UGT2B15 STS DIO1 CYP17A1 STAR PMC4040584__F1 Expansion of the SDF-1/CXCR4 migratory signaling network in breast cancer stem cells ITGB4 HEL-S-80p CXCR4 TLK1 ARFGEF2 MAP2K2 PTPN13 CDK3 HEL113 MYO9B CDK7 PMC3894712__F4 Autophagy in Kidney Health and Disease ATG12 MTOR DKFZp686F0183 PMC5601256__F3 Natural killer (NK) cell activating receptor signaling FYN RAE1 LCK VAV1 ZAP70 GRB2 SYK PMC9453876__F14 Honokiol improves depression-like behaviors in rats by HIF-1Alpha- VEGF signaling pathway activation EPO MTOR PSD PMC9027058__F2 KRAS: A Druggable Target in Colon Cancer Patients EGF EGFR GRB2 MTOR PMC9477010__F3 Pyroptosis and its crosstalk with immune therapy in breast cancer NLRP3 DRD2 GSDMC AIM2 GSDMD STAT3 BAX DFNA5 PMC9477010__F1 Pyroptosis and its crosstalk with immune therapy in breast cancer NLRP3 HMGB1 NLRP1 GZMA GSDMC AIM2 GSDMB GSDMD DFNA5 PMC6614129__F3 Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders BAD GSK3B HDAC2 TRAF2 HDAC1 PMC8299191__F6 Map of dimorphic switching-related signaling pathways in Sporothrix schenckii based on its transcriptome CIB2 RALBP1 CDC42 GPD1 PMC8350388__F1 Role of Traditional Chinese Medicines by Wnt/Beta-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy EGF RNF43 BTRC APC EGFR GSK3B GPR49 PMC5717492__F8 EMT signaling induced during P MMP2 GSK3B PMC2852600__F2 CD40 responsiveness in Leishmania-infected macrophages: crosslinking of anti-CD40 antibody activates p38 MAPK-induced leishmanicidal function via iNOS2 induction STAT1 CD40 PMC4556375__F5 Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease PRMT1 HEL-S-182mP PC HMGCR PMC7656798__F1 PI3K/AKT/mTOR signaling pathway in cancer TSC2 TSC1 PTEN MTOR PMC3184251__F1 Smac mimetics and TNFA: a dangerous liaison? TRADD TNF TRAF2 FADD PMC5412537__F1 Diagram of IL-10 and IL-10R pathway TYK2 JAK1 STAT3 PMC5362499__F4 LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies PERP PMC8616345__F2 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer SMAD2 SMURF2 SMAD4 TF PMC8255536__F4 Proposed mechanism on cartilage repair and chondroprotective effects of IGF1-induced SMMSC-CM therapy ADAMTS4 IGF1 BMP2 IL13 FGF18 SOX9 PMC4099360__F1 Toll-like receptor 4 and hepatic fibrogenesis CD14 TLR4 LBP TRAF6 IRF3 MYD88 TIRAP PMC8900732__F1 The Cannabinoid System in the Basal Ganglia in Parkinson’s Disease GPR55 TRPV1 PMC5426649__F8 Hypothetical model for IGF-I regulation of kitlga expression and its signaling mechanisms in the zebrafish follicle cells EGF EGFR PMC8616345__F4 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer SMAD2 SMURF2 SMAD4 TF PMC9271914__F1 Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease CYP27A1 FGF19 CYP7B1 FGFR4 CYP7A1 PMC5083749__F1 Upstream and downstream signaling in the mTOR pathway IGF1R BRAF ATM EGFR GSK3B VHL FGFR3 PTEN MTOR SSTR5 BAX PMC11054859__F6 KEGG pathway (hsa05226 gastric cancer) POLK APC SHH SMAD4 MUC2 PMC11054859__F5 KEGG pathway (hsa05200 pathway in cancer) STATH FADD PMC5267446__F3 Acute myeloid leukemia and oncogenic Hedgehog/GLI signaling SMO FLT3 MTOR DYRK1B DYRK1A BRD4 PMC12191077__F1 Proton-sensing GPCR-related signaling pathway GPR68 GPR132 GPR4 RHO GPR65 PMC7602033__F2 Cardiac remodeling by microRNAs and the functions of their target mRNAs PTEN RAF1 STAT3 PMC11054859__F7 KEGG pathway (hsa04151 P13K-AKT signaling pathway) TSC2 BAD BCR PTEN POR MTOR EIF4B RBL2 RHEB CD19 PMC3276472__F1 Schematic in vivo biosynthetic pathway from 18:3n3 and 18:2n6 mediated by ELOVL4 and other ELOVL family proteins ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC2783774__F4 miRNA process pathway DGCR8 DICER1 TNRC6A SNIP1 RAN TARBP2 PMC3092604__F1 General scheme of the SBP in Tritryps PC CERS3 SMS KDSR PMC4981705__F1 PI3K/Akt/mTOR signaling pathway and the existing molecular targets for therapy, which was indicated by ∆ TSC2 TTI1 RICTOR TSC1 PTEN MTOR DEPTOR IRS1 RHEB MLST8 PMC3092604__F2 Lipid remodeling pathways in mammals, yeast and T PGAP2 PGAP3 BST1 CWH43 PER1 PMC11056518__F3 IL-23 and IL-12 and their receptors, with summary of associated effector cells, cytokines, and immune function STAT4 TYK2 IL23R STAT3 PMC9138510__F1 TGFB as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications SMAD2 TGFBR1 TGFBR2 SMAD4 TF PMC4755014__F5 KEGG pathway map (cin04310) of the WNT Signaling Pathway with DE genes indicated ROCK2 BAMBI INVS APC SOST LRP5 CER1 SMAD4 LRP6 SKP1 ARHA RBX1 SOX17 NLK DAAM1 SIAH1 UNK PMC5368692__F2 MYC-dependent metabolic reprograming in immunity As schematically shown here, MYC regulates immune cell metabolic reprogramming in different contexts BCR MYCL MYC PMC4175497__F1 Molecular signaling altered in Fragile X syndrome MAP1B MMP9 GSK3B APP ARC ACHE PMC8048291__F9 Schematic depiction of endolysosomal pathway dysregulation in Huntington’s disease CD63 HTT PMC11655665__F0 Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFKB1/CXCL9-mediated tumor growth and metastasis CYP2J2 PLEC NFKB1 CXCL9 PMC12041774__F6 Effect of TCM monomers, formulations and small-molecule inhibitors on the Wnt/Beta-catenin signaling pathway NLK LEF1 CYLD MYC RAC1 BCL9 WLS PMC12041774__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC12041774__F3 Effect of angiogenesis in CRC APC GSK3B LRP5 LRP6 IL6 PMC8318642__F3 Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome CMTM7 BCR CMTM3 BASH CMTM6 CMTM2 IL1B CMTM1 PMC11693507__F2 IL-6 signaling pathway in kidney cells SOCS3 CXCL5 AXL STAT3 PMC9606688__F2 mTORC1 beyond anabolic metabolism: Regulation of cell death ULK1 GCLM KEAP1 GCLC SLC7A11 NF2 HEL-S-64p LATS1 PTEN SESN2 LATS2 PMC8529048__F2 Anti-flavivirus Properties of Lipid-Lowering Drugs MVD DHCR7 HMGCR PMC5811610__F6 Sialylation pathway in eukaryotes CMAS SLC35A1 SLC17A1 NANS SLC17A9 SLC35A4 NANP SLC35A5 PMC12234022__F3 Chemically modified ncRNAs in diseases METTL14 METTL1 YTHDC2 GCLC WDR4 HEL-S-15 DKC1 NOP2 NOP58 YTHDC1 NSUN2 PMC9393728__F8 EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway MYC TNF PMC5270476__F1 Reelin's role in stabilizing the cytoskeleton LIMK1 VLDLR GSK3B DAB1 MTOR CRK CDC42 PMC4453536__F8 Regulation pathway from HBV infection to complement activation CD59 CD46 CFH IRAK2 TRAF6 CD55 IL1B PMC12192919__F2 Myostatin-mediated muscle atrophy in SMA SMAD2 MSTN PMC8146031__F2 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels IGF1 MYC PTEN MAL PMC4875670__F2 Network of gene interaction NF-KB pathway obtained from the subtraction of the control Hep-2 cells EDAR DUSP9 ZNF675 CDC42SE1 PMC8146031__F8 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels AREG CXCR4 TP73 MICA ATR PTGS1 CD24 PMC3073487__F4 Functions of 14-3-3 in tumor-suppressor pathways LATS1 LATS2 PMC10310986__F5 Histone post-translational modification and the DNA damage response SIRT7 HDAC3 TRIM66 BRCA1 SIRT1 PMC8990993__F5 Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus TRADD IL8RB FADD PMC6275466__F3 NOTCH signaling in B cell development NOTCH2 PREB NOTCH1 PMC6749531__F7 Active constituent-protein targets-signaling pathway network of frankincense–myrrh compound against breast cancer PALB2 BRCA2 PTPN1 PTGS2 NBN MSH2 MTOR ATR RAD51C PMC7843420__F8 STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis CD151 TWIST1 LIF MSC GRB2 CD83 IL6 IL6R GATA3 STAT3 PMC6275466__F2 NOTCH signaling pathway NUMB FURIN CDK8 PMC8609314__F6 Activation of PTH1R alleviates epididymitis and orchitis through Gq and Beta-arrestin-1 pathways PTH1R CXCL10 IL6 TNF PMC8623313__F1 Kinase-Inhibitors in Iodine-Refractory Differentiated Thyroid Cancer—Focus on Occurrence, Mechanisms, and Management of Treatment-Related Hypertension RET MTOR PMC5138252__F4 Examples of genes (in red) within the HIF pathway in which positive selection has been identified in high-altitude populations EGLN3 EPO NOS2 HIF1A EGLN2 NR1C1 EGLN1 ARNT2 PMC6952783__F1 Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases CCL24 CCL17 TRAF6 PMC3870610__F8 Signaling pathway of the AMH protein AMH SMAD4 AMHR2 SMAD1 DKFZp781O1323 PMC8263891__F6 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology RELA APP INSL3 RXFP2 PMC8263891__F5 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology CD14 NLK MAX HP PROC TRO GCK TRAF2 MEF2C PMC5297752__F1 Unfolded protein response (UPR) pathways in mammalian cells ATF4 TRAF2 PMC10605634__F1 Tumor intrinsic factors related to immune evasion and ICI resistance HLA-A APC GSK3B SMAD4 JAK1 LAG3 B2M IRF-1 HLA-B HLA-C PMC6408937__F1 T cell activation induces cell surface expression of GLUT1 and amino acid transporters, facilitating uptake of glucose and glutamine OGA OGT PMC9241034__F6 Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSA facilitates processing of oxidative DNA damage in human cells SET ATM SETD2 PMC12204016__S1 Expression of exosome miR-30a-3p was up-regulated in the lead (Pb)-exposed group, suggesting that the abnormal expression of exosome miR-30a-3p derived from osteoclasts may be involved in the Pb-exposed group TH IKBKG GSDMD PMC9427794__F7 Schematic model of GASP1 promoting malignant phenotypes of breast cancer cells and decreasing their response to paclitaxel by forming a positive feedback loop with the IGF1/IGF1R pathway IGF1R IGF1 MDM2 PMC2536824__F4 Ingenuity Pathway Analysis (IPA) of genes specifically overexpressed in B1-Arg389 transgenic mouse hearts EDNRA SKIL MAPK10 TIA1 PMC12176239__F1 RA signaling pathway regulates the dynamic balance of differentiation and proliferation in LECs CYP26A1 RBP1 LRAT FABP5 PMC10380640__F4 Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology C9 MASP1 MASP2 C4A PMC8971670__F5 Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers FKBP5 TMPRSS2 PMC12174920__F4 Molecular mechanism of KGN induced Hippo/TAOK1 Signalling Pathway MOB1A MOBKL1A PMC6715949__F1 Mucosal innate immune responses to STIs in the female genital tract that could potentiate HIV transmission risk IRF7 IRF3 MYD88 IL1B PMC9085972__F11 BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance RAB35 TBC1D10B BAG3 PMC6898841__F5 The schematic presentation for the signaling of the top 3 kinases crucial for cardiomyocyte survival IGF1R IGF1 MTOR PMC8584457__F1 Targeting Inflammatory Signaling in Prostate Cancer Castration Resistance PPP3CC LTB RELB PMC7551521__F1 Immune responses induced by SARS-CoV-2 TBK1 IRF3 MAVS PMC5416822__F3 Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases CGAS STAT2 IRF9 GBP5 RIPK3 IFNAR2 MYD88 IFNAR1 ZBP1 STAT1 NLRP3 TLR7 TLR4 GBP2 CASP8 AIM2 FADD MAVS PMC4552438__F8 Paracrine networks acting downstream of epithelial ESR1 in the mouse uterus during implantation IHH PGR BMP2 PTCH1 LIF EGFR HBEGF PMC8102595__F1 Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves SIRT2 CTBP2 RBP1 SETDB1 EBP BMP2 CTBP1 CEBPA SENP2 FOXC2 HEL-S-104 FBXW7 KLF3 LEP EGR2 LPIN1 BSCL2 MSC LPL EZH2 SMAD1 PMC9395612__F2 Research progress on exosomes/microRNAs in the treatment of diabetic retinopathy DOK5 TRADD SMAD2 SMAD4 PTEN TNF TRAF2 PMC5132409__F3 Retinoid transformations and enzymes of the classical and intraretinal visual cycles RDH14 LRAT RPE65 RDH8 RDH5 RPE PMC6907741__F3 Regulatory Mechanisms of B7x Expression RELA SMAD4 STAT3 PMC3309773__F1 Regulation of ISGs by Akt1 and EMSY STAT1 ISG15 STAT2 IRF9 EMSY IFITM1 PMC7291868__F4 Common neuroinflammatory pathways in different neurological diseases regulated by miR-146a CFH IRAK1 TRAF6 MYD88 PMC6917592__F1 Induction and subversion of the innate IFN response by HCMV IFIT3 TBK1 CGAS IFIT2 TLR9 IFITM3 IRF9 IFITM2 IRF3 MYD88 ZBP1 IFITM1 IFNG ISG15 JAK1 MAVS STAT3 IFIT1 PMC8507163__F5 Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis PIK3CD PIK3R1 FHIT ALK HEL-S-1 MYC RB1 POR CDKN2A E2F3 PRKCA PERP RAX HTT CDC27 CRABP2 HRAS PIK3R3 PRKCB MCM2 RORA ATR AKT3 BAD BRAF HEL2 TTK EGFR PTEN CASP2 ORC2 RARB RXRB ATM EML4 E2F2 ARAF BAX POLK SKP1 RXRG RFWD2 CASP3 EFS EP300 PIK3CA RAF1 SKP2 CYCS ANAPC10 PMC2704251__F1 Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics? CXCR4 MYD88 TLR1 TIRAP PMC2765277__F5 Amino acid producing elementary flux patterns ASIP CIT MAL GLS PMC4309737__F4 PTEN-PI3K-AKT pathway in oocytes regulates primordial follicle activation EGF KIT PTEN PMC2765277__F3 Scheme of part of the central metabolism of E ASPA CIT MAL PMC4309737__F3 Actin polymerization disrupts ovarian Hippo signaling and promotes nuclear YAP actions to increase downstream CCN growth factors and apoptosis inhibitors involvement in POI, PCOS, follicle reserve, and infertility TEAD3 DIAPH2 TEAD4 LATS1 LATS2 FOXL2 CTGF TEAD2 PMC11033207__F6 Redox signaling and skeletal muscle adaptation during aerobic exercise MT3 GPX4 TRADD RELB LTB TNF SIRT3 MAF COX2 SIRT4 RELA HEL-S-44 SIRT1 FADD LTBR PMC6709869__F2 Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging MSC BCL2 CXCL12 MTOR NR1C1 SIRT1 TICAM1 CDC42 PMC11033207__F1 Redox signaling and skeletal muscle adaptation during aerobic exercise AQP8 NOX4 PMC6882982__F6 Most significant module of PPI network of DEPs involved in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway ITGA1 COL4A4 COL3A1 LAMB2 LAMA3 LAMA1 ITGB4 COL4A6 LAMB1 COL4A3 ITGA6 COL1A2 COL2A1 LAMC1 LAMA5 LAMC2 COL4A1 AGRN PMC6882982__F5 PI3K-Akt signaling pathway changed in FSH-positive relative to negative NFPAs BAD FAR1 MEI1 PTEN RAC1 EIF4E MTOR RHEB RXRA TSC2 PI3 BCR MDM2 SYK RBL2 CD19 PMC3776022__F1 GABAA receptor subunit regulation after status epilepticus (SE) BDNF STAT3 PMC3309773__F7 The functional role of Akt1, EMSY, and BRCA2 in the regulation of ISGs STAT2 BRCA2 IRF9 EMSY TYK2 IFNAR2 JAK1 IFNAR1 PMC12174920__F8 Molecular mechanism of KGN induced JNK/RUNX-1 signalling pathway RUNX1 RUNX2 SOX9 PMC12174920__F7 Molecular mechanism of KGN induced AMPK-SIRT1/Antioxidant signalling pathway SP4 SMAD4 SMAD1 SIRT1 DKFZp781O1323 SOX9 SMAD9 PMC12174920__F6 Molecular representation of repressed (left), in absence of hh ligands and activated (right) KGN induced hh signalling pathway, in presence of hh ligands DHH IHH GLI3 SHH SMO PMC8182896__F2 Ang/Tie signalling pathway under physiological and pathophysiological conditions VCAM1 GRB2 IQGAP1 VEGFA RAC1 TIA1 FOXO1 PMC7921686__F8 Integrated pathways map of fucosterol in the treatment of NSCLC include (A) the non-small cell lung cancer pathway, marked in yellow as the functional targets of fucosterol, and (B) the key signal transduction pathways FHIT BAD DAO CASP9 PMC7921686__F7 Target-pathway network, constructed in Cytoscape3.7.2 (https://cytoscape.org/), was built by the candidate targets and a pathway if the pathway was lighted at the target KIT MAPK8 PGR BMP2 MMP3 CASP3 RARA ERBB4 KDR MMP2 CDK2 PTPN11 MDM2 IL2 JAK3 PMC6138560__F2 Immunobiology of Ubiquitin-Dependent B Cell Receptor Functions SYK ITCH CBL PMC7917218__F1 The Unfolded Protein Response (UPR) is regulated by three transmembrane endoplasmic reticulum (ER) receptors: PERK, ATF6 and IRE1A ATF4 EIF2A TRAF2 XBP1 PMC9298971__F1 Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation POMC IGF1 AgRP PMC7603112__F1 Vitamin D metabolic pathway by cytochrome P450 oxidases (CYPs) CYP27A1 CYP2R1 CYP24A1 CYP27B1 PMC3931394__F2 Transcriptomic analysis of isolated islets from GLU+IL–infused 6-month-old rats PLK1 HBEGF UCP2 PMC3438361__F2 Illustration of the metabolic pathway analysis for zidovudine with thick arrows indicating targets identified by the automatic classifier CYP2C9 CYP3A4 SLC22A7 SLC22A11 SLC22A6 UGT2B7 SLC28A3 HEL-S-20 CYP2E1 AMT NDP PMC7519869__F7 Diagram presentation of the molecular mechanism CCND1 PMC5794005__F1 Denosumab: Targeting the RANKL pathway to treat Rheumatoid Arthritis NFATC1 TRAF3 OSCAR TRAF6 IFNG PMC6931156__F2 Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD)-Associated Genes Converge on the Lysosome CHCHD10 TBK1 SNCA TMEM230 LRRK2 OPTN PFN1 GRN FUS PINK1 TMEM175 SYT11 HEL-S-44 CHMP2B TMEM106B C9orf72 CHCHD2 PMC6931156__F3 Rab Proteins Have Convergent Roles in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD) TBK1 RAB35 RAB1A TMEM230 LRRK2 CHMP2B RAB39B C9orf72 RAB10 PMC11694147__F7 Mechanism of protective effect of Herpetospermum pedunculosum seeds on liver KEAP1 SMAD2 SMAD4 PMC3321808__F4 Differential regulation of genes in the IL-10 pathway in neonates and school-age children with septic shock versus age-matched controls SOCS3 LBP TRAF6 TYK2 SP1 TNF HEL-S-29 STAT3 PMC2168724__F1 Coenzyme B12 biosynthesis in serovar Typhimurium APP NDP PMC3321808__F5 Differential regulation of genes in the antigen presentation pathway in neonates and school-age children with septic shock versus age-matched controls MHC2TA HEL-S-269 ALB HEL-S-99n IFNG PMC9233348__F1 Cytokines and microRNAs in SARS-CoV-2: What do we know? PIGF SOCS3 TNF ACE2 PMC3693579__F5 Signal transduction in MMTV-Pax8PPARG mice GSK3B PTEN CD24 PMC3562414__F2A Surfactant phospholipid metabolism PC PGP PSD PEMT PMC5061430__F6 Role of the Tomato Non-Ripening Mutation in Regulating Fruit Quality Elucidated Using iTRAQ Protein Profile Analysis BAK1 ERF CAD EED PMC8926997__F7 Mechanism and Function of miRNA in Intervertebral Disc Degeneration CUL4B CUL4A PMC7768255__F3 Starvation Responses Throughout the Caenorhabditis elegans Life Cycle ALK PTEN PMC5787446__F4 Drug resistance related to aberrant glycosylation in colorectal cancer EGFR CD44 PMC5787446__F3 Drug resistance related to aberrant glycosylation in colorectal cancer CES2 ATP7B CES1 ABCC1 ERCC1 ABCC11 SLC29A1 ABCG2 ERCC2 ABCC2 ABCB1 SLC19A1 PMC6379582__F6 Model hypothesizing the potential regulation of Beta-catenin by G-alpha subunits and PMT APC RHO PMC9106457__F5 Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications SMAD4 PMC4655987__F1 Aerobic very long chain-PUFA biosynthetic pathways modified from Napier () including microorganisms, plants, and animals TNLG7C GLA FADS6 PMC9414791__F12 Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice ChAT IL16 GC TNF BAX PMC4960658__F2 p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression ERBB2 EGFR SRC ARHA RAC1 PMC9588904__F5 Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation NAGK STAC ST7 MYC PROC FBN1 AHNAK PTEN MTOR TFCP2 MTHFD2 DHX29 UBC MUC12 A2M ATM APP HEPACAM2 PCK2 PIGA COL4A4 LACRT FAM9B MRAP2 IGF2 HRAS ITGAM EP300 MAX NMRK2 UGCG SUFU TXNIP THADA PMC5935233__F3 Oncogene-induced genomic instability PALB2 RECQL4 BLM BRCA2 RAD50 WRN BRCA1 PMC7410499__F1 Functionally annotated network of genes involved in the hypertension-hypotension axis whose expression across the GTEx population is correlated and anticorrelated with the AGTR1 and AGTR2 receptors CTSA PMC5867859__F2 Wnt signalling in the adult Drosophila midgut during homeostasis, regeneration, ageing and hyperplasia APC EGFR TNKS HDC PMC9099915__F2 Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way? TBX5 GATA4 PMC3917548__F1 The interleukin (IL)-21 receptor signaling pathway IL21R SHE JAK3 STAT3 PMC3950548__F2 Representation of IL-33 pathway in T-helper cells IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC2759052__F1 Signal transduction pathway mediated by epidermal growth factor receptor (EGFR) TSC2 EGFR MTOR PMC7047088__F3 HIF-mediated gene expression in metabolic reprogramming LONP1 PFKFB1 ENO1 PFKFB4 PFKL CA9 HEL-S-87p CITED2 HEL-S-68p HEL-S-162eP HEL-S-49 GIG8 PFKFB2 BNIP3L TKTL2 BNIP3 HEL107 HEL-S-133P MXI1 HK2 PMC4155324__F4 Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma CCND1 SP1 PMC5722633__F4 Mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain PITRM1 HOMER2 SHANK1 HOMER3 BAIAP2 HOMER1 SHANK3 SHANK2 SRCIN1 SYNGAP1 PMC11077374__F3 HuR during Wnt/Beta-catenin signaling pathway, autophagy and drug resistance in pancreatic cancer HEL-S-26 WEE1 EIF3B WTAP PMC7511812__F7 Major molecular pathways IL16 CDK9 IL1B PMC11077374__F1 LncRNAs in modulating the Wnt/Beta-catenin signaling pathway in pancreatic cancer HOXA9 FOXM1 FOXO3A CTBP1 APC LRP6 DKK1 WTAP TOP2A WIF1 FOXO1 PYGO2 BRI3 WDR5 EIF3B EZH2 TEX10 PMC11077374__F7 HIF in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer SMAD4 BNIP3 CDK8 EGLN2 PGAM1 VMP1 TCF4 PMC11077374__F5 FOXM1 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer FOXM1 PMC11077374__F4 FOXO1 and FOXO3 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer FOXO3A NOX4 SIRT1 FOXO1 PMC11077374__F8 FOXO3-FOXM1 axis in regulating drug resistance in pancreatic cancer FOXO3A FOXM1 PDHA1 CD44 PMC11855704__F3 Wnt/Beta-catenin pathway in the pathogenesis of obesity CXXC5 ADD1 UCP1 NOTUM LRP5 ARHA RYK STAT3 OSBPL2 PMC6952374__F7 Role of ALK5 and non-canonical androgen signaling in ADPKD GPRC6A SMAD2 OXER1 PMC11855704__F2 Application of MAPK, PI3K, and JAK/STAT signaling pathways in the pathogenesis of obesity POMC IGF1 NPY UCP1 AgRP Nucb2 IRS1 UCP2 PMC4810556__F1 Inhibition of innate immunity by arenavirus NP and Z STAT2 IRF7 IRAK1 IRF9 TRAF3 TRAF6 IFNGR2 IRF3 IFNAR2 MYD88 TLR1 IFNAR1 IFNG STAT1 TYK2 JAK1 MAVS MAL PMC7268735__F1 Illustration of CDC25C regulation (Green arrows indicate the enhancement effects and red indicator lines indicate the inhibitory effect) PIN1 PLK1 WEE1 ATM CDK4 CDC2 ATR C13orf34 PMC4763866__F1 Schematic pathway of SOCE in neutrophils, leading to activation of the NAPDH oxidase ORAI3 ORAI1 STIM1 STIM2 PMC9525271__F8 ADH1C inhibits progression of CRC by ADH1C/PSAT1/ serine metabolic pathway PSAT1 PSPH ADH1C PHGDH PMC8147992__F2 Fibrotic Events in the Progression of Cholestatic Liver Disease JAG2 SMO FZD1 HES1 PMC5368180__F1 Nanotechnology-based therapy for prostate cancer CD44 PSCA PMC7641946__F2 Therapeutic Application of MMEJ for Cancer Treatment WEE1 ATR PMC7641946__F1 DSB Repair Pathways FEN1 HMCES RAD51 PMC3540819__F1 Main signaling pathways involved in thyroid carcinogenesis are the MAPK and PI3K-AKT pathway (reproduced with permission) BRAF PTEN MTOR PMC3686815__F9 Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway ChAT ACHE APOE PMC12226585__F1 ADSCs/ADSCs-exosomes mediates a multidimensional network of mechanisms for IRI repair FGF21 HGF MPO NQO1 PCNA STAT3 BAX PMC8616591__F2 Glypican-1 in regulating multiple cellular signaling pathways ZNRF3 GPC1 RNF43 LRP5 UST LRP6 GPR49 LGR6 PMC7564666__F6 Protein Expression of Let-7a Target Genes are Altered in a LASP1-Ago2 Interaction-Dependent Manner AGO2 AAG1 CCR7 CCND1 CXCL12 PMC3940310__F4 Endogenous fatty acid metabolism in the control of hepatic gene transcription RICTOR FADS2 PCK1 ELOVL5 FADS1 ELOVL2 NR1C1 FASN PMC6362574__F1 Metabolic engineering strategies for enhancing citric acid production AOX1 CIT GLA MAL PMC7358452__F8 The in vitro effects of the poly(I:C) ENCPs developed in this study CD163 CD80 TLR3 PMC3940310__F2 Pathways for hepatic fatty acid synthesis (FASN) FADS2 SCD ELOVL5 FADS1 ELOVL6 ELOVL2 FASN PMC4442291__F2 Schematic summarization for the signaling mechanisms of the antifibrotic effects of H2S TLR4 SMAD2 SMAD4 NOX4 MYD88 SIRT1 PMC4928052__F3 Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma GNPAT SMPD4 PC CHKA PCYT2 PMC6192420__F2 Overview of the vitamin D metabolic pathway CYP27A1 PIM1 CYP2J2 NR1i1 DBP SNAI2 PMC9570242__F6 Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep TRPC1 AGTR1 SMAD2 SMAD4 TRPC3 ORAI1 PMC6178832__F2 Molecular features of the JAK-STAT signaling pathway STAT2 IRF9 IFNAR2 IFNAR1 IL23R IL12RB1 STAT1 STAT4 IL15RA TYK2 JAK1 IL2RB STAT3 PMC7493825__F3 NLRP6 inflammasome in health and disease NLRP6 MYD88 TLR1 MUC2 PMC7236859__F1 Proposed mechanisms of exercise cardioprotection ERBB4 IGF1 ERBB2 PMC4805534__F7 Schematic illustration of GSK3B/eIF2BE and mTORC1 signaling in AKT-induced CNS axon regeneration ELF2 TSC2 TSC1 GSK3B PTEN EIF4E PMC8698915__F4 Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways HEL-S-62p HMGB1 C9 MASP1 C6 SERPING1 C1S PMC8464970__F7 Ergosta-7,9(11),22-trien-3Beta-ol Attenuates Inflammatory Responses via Inhibiting MAPK/AP-1 Induced IL-6/JAK/STAT Pathways and Activating Nrf2/HO-1 Signaling in LPS-Stimulated Macrophage-like Cells RIPK1 TLR4 TRADD KEAP1 IL6 MYD88 TIRAP PMC9189780__F8 DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway MMP2 DNTTIP1 DUSP2 HDAC1 PMC9687482__F4 Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets APP APOE PMC12079191__F1 Diagram of the ICG-CuET@PLGA-CS-HA (IC@PCH) nanoparticle (NP) synthesis procedure NLRP3 CS CD44 PMC8472292__F2 On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease NLK APC ARHA RYK DKK1 CDC42 PMC4110625__F1 Model of ER stress-associated inflammation TRAF6 TRAF2 XBP1 IL1B PMC3615671__F2 Metabolic modulation of epigenetics in gliomas EGF HDAC3 EGFR PMC3927995__F2 NFAT proteins activate an anergy-inducing program of gene expression CASP3 TLE4 ZAP70 CSA2 JUN SIRT1 LAT ITCH IFNG DGKA PMC7703729__F8 Proposed intracellular mechanism of GRP78 and protein kinase A (PKA) signaling pathway activation by vaspin on basal and IGF-1 and gonadotropin-induced steroid synthesis in ovarian cells NR3A2 PGR CYP11A1 FSHR LHCGR CYP17A1 STAR PMC8946789__F8 The Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring TIMP1 RUNX2 SOX9 PMC7284105__F2 Feed-forward autocrine YAP activation ERBB3 EGFR HBEGF NRG1 PMC7284105__F1 Canonical Hippo kinase module LATS1 LATS2 PMC7926305__F5 Molecules associated with the canonical pathway (CP) ERK/MAPK signaling in the function of two stages of oocyte development RRAS CP PMC7926305__F4 Common proteins identified in the three replicates of canine in vitro oviductal cell-derived extracellular vesicles that participate in the canonical pathway (CP) ERK/MAPK signaling BAD MOS NFATC1 GRB2 SRC DOCK1 EIF4E CRK PXN PMC3336361__F4 Apoptosis pathways BAX PMC3405333__F11 P38 MAPK signaling pathway MAX ATF2 TRAF6 ATE1 TNF TRAF2 PMC3405333__F10 ERK/MAPK signaling pathway BAD MOS BRAF EIF4E PMC4887206__F6 Drosophila and vertebrate patched orthologs share a similar cis-regulatory architecture and gene regulatory strategy SAG CTCF GLI3 FANCE PMC7166201__F1 PTEN, a PAK1-blocker, interferes with coronavirus –induced PAK1-dependent signalling pathway leading to lung fibrosis PAK1 PTEN CCL2 ACE2 PMC4585452__F4 Schematic model of WNT signaling by the FZD receptor(s) NLK APC RHO PMC5745011__F2 Pericytes of the neurovascular unit: Key functions and signaling pathways EGFR GRB2 SRC SP1 MTOR FOXO1 PMC5745011__F4 Pericytes of the neurovascular unit: Key functions and signaling pathways RBPJ SMAD2 GSK3B PLVAP TGFBR2 VEGFA SMAD4 NRARP LEF1 NRP1 DLL4 VTN CDH2 SMAD1 ABCB1 PMC4810382__F2 EGFR- and ALK-signaling pathways and their respective inhibitors EML4 ALK EGFR MTOR PMC2883292__F2 Signaling through the PI-3 Kinase-Akt pathway BAD HEL-S-28 SRC MTOR IRS1 AKT3 PMC7555855__F1 Major targets of amino acids, peptides, and their analogs for the control of skin pigmentation GSK3B DCT TYRP1 MC1R PMC9634190__F1 Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer TBK1 TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC9687047__F8 Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo NLRP3 TLR4 IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC3962777__F2 NEW STRATEGIES FOR TRIPLE NEGATIVE BREAST CANCER – DECIPHERING THE HETEROGENEITY WEE2 WEE1 ATM BRCA2 EGFR PTEN INPP4B MTOR ATR BRCA1 PMC2847412__F1 Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis ATF4 EIF2A F11 ATF6B XBP1 PMC9313042__F1 Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases TH IRAK1 TRAF6 IRAK4 MYD88 IL18BP IFNG PMC3594951__F1 This figure schematically shows the tyrosine kinase receptors, such as RET, EGFR, FGFR, MET, KIT, VEGFR, PDGFR, and some of their downstream effectors KIT RET BRAF EGFR PTEN MTOR PMC6562585__F4 Regulation of YAP/TAZ in epidermal cells SRC LATS1 MOB1A ITGB1 MOBKL1A WBP2 LATS2 PMC8987729__F8 Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes MYL2 GATA6 TNNI1 MYH7 MYL7 GATA4 CACNA1C COX6A2 HEY2 NKX2-5 KCNJ2 HCN1 TBX5 ATP2A2 COX7B HAND2 CD36 PMC4155833__F3 Dual role of Nrf2 in cancer.Notes: As long as it is kept under homeostatic control, Nrf2 activation protects cellular components like DNA from damaging insults arising from acute/temporary oxidative and xenobiotic stress KEAP1 SFN PMC8268779__F1 Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease COX2 COX1 PMC7460550__F2 Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population PRKCA FOXO1 CP CCNO IFNG PMC9252714__F9 Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death FADD BAX PMC6456554__F7 Schematic representation of the outlined hypothesis LDLR ABCA1 PMC3399530__F2 Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease CAPZA2 SNCA SDCBP CS MAPK3 NEF3 NEFH RHO SNAP25 RDX LCP1 CDKN1C PCP4 SCIN GIG8 POLR2A ERMN HEL-S-44 GNAS GDI1 RHOB GPNMB PMC4514860__F1 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway ROCK2 BAMBI APC SOST SMAD4 SKP1 ARHA PMC2695762__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity TLR8 TLR5 CARD9 TLR7 TLR4 TLR9 BCL10 TLR1 NOD2 TLR3 PMC6671812__F12 Proposed model of IL-18-mediated microglia/astrocyte interaction in the spinal cord TLR4 IL18BP BDNF PMC4471869__F3 Interleukin-33 in tissue homeostasis, injury and inflammation IL33 TSLP PMC4514860__F2 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway BAMBI SOST SKP1 PMC9396350__F6 Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection EPOR VEGFC TLR4 EPO MARCO WDR5 IRAK3 PMC5617803__F1 The pikromycin (Pik) biosynthetic pathway DES CP HEL-S-5 PMC5832166__F7 TGFB1 signaling in hMSC differentiation HEL70 PLAT EGR2 SOS2 FGF2 MEF2D PMC7449921__F8 Working model of how MAD2 downregulation promotes asymmetric division and reduces tumor growth and invasion in MKN45 cell line CXCR4 SNAI2 PMC7351433__F1 Simplified scheme of cellular pathway and the targets of MTX RFC1 GGH DHFR TYMS MTHFD1 HEL-S-70p ABCG2 FPGS PMC7944129__F6 Regulatory network of different pathways HEL-S-62p CD9 F10 CS OMP DAP CPB2 FRY C9 PC A2M FH LYN VWF CR2 OTP PMC2630276__F7 Model for the role of Hedgehog in the recovery of the BMP4-dependent stress erythropoiesis pathway in the spleen DHH IHH BMP4 PMC6433939__F1 Schematic diagram shows the regulatory non-coding RNAs in NAFLD disease development and progression HNF4A PLP2 ACTA2 SMAD2 PTEN KLF6 NR1C1 PER2 MTTP PMC7797046__F5 Schematic showing the biosynthetic pathway of OHyW in wild type cancer cells (blue area) and taxol resistant strains (red area) TYW3 TYW1 TYW5 PMC152905__F6 Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line REV1 XRCC3 RAD18 PMC9350527__F1 Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids CYP27A1 GCA CYP8B1 CYP7B1 CYP7A1 PMC2981456__F1 The estrogen biosynthesis pathway CYP1B1 HSD3B1 HSD17B1 PMC4583600__F2 Cell biology functions and pathways of the genes involved in melanoma susceptibility TERF2 BARD1 FOXK1 BRCA1 TERF2IP ASXL2 OGT ASXL1 MDM2 CCND1 YY1 CDK4 ACD TERF1 HAT1 FOXK2 TERT PMC317073__F7 Regulation of TNF-R1signaling pathways during apoptosis TRADD TRAF2 FADD PMC8463866__F1 Production and Function of Endogenous Interleukin-10 in Intestinal Epithelial Cells and Gut Homeostasis CASP3 TNF CASP8 PMC3315606__F1 Roles for prions and protein-only inheritance in cancer MMP11 CCND1 TNF BAX PMC7463967__F4 Network of known interactions between RTKs and the Hippo pathway EGF SOX2 ALK EGFR AJUBA LATS1 RHO HIF1A IRS1 LATS2 RET ERBB4 MERTK EPHB2 STAT3 GLS ITCH PMC6139616__F1 Hepatic lipid metabolic pathways investigated in this study UGT1A3 CPT1A DROSHA ACLY TG HMGCR FASN PMC7033839__F1 Proposed mechanism of statins, colchicine, and aspirin on the reduction of radiation‐associated cardiovascular disease (RACVD) IL13 IL6 RHO IL4 PMC11172987__F2 Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC3344210__F4 The effects of curcumin on the TNFA receptor and its downstream signaling pathway OCEL1 IL18 SOS1 TNF TRAF2 PMC7463967__F1 Illustration of the Hippo pathway and its regulation in mammalian cells EGFR LATS1 LPA LATS2 PMC4410181__F2 Control of regulatory T cell lineage commitment and maintenance BCL10 SP1 FOXP3 PMC9795026__F1 Toolkit for plant lipid engineering: Surveying the efficacies of lipogenic factors for accumulating specialty lipids PC EPX LPA PMC6494966__F1 Schematic depiction of processes and pathways involved in iron homeostasis and regulation in the brain LDLR APP FBXL5 PMC5239436__F1 Autophagy complexes cell death by necroptosis RIPK1 TRADD RIPK3 TRAF2 FADD MLKL BAX PMC6091082__F3 The applied conditions on the expression of central metabolism genes PML GIP TNLG7C HEL107 ART1 RPE AMT SDHA PMC5992122__F1 Universal Pathway for the Biosynthesis of Coenzyme A and Associated DiseasesIn green are indicated genes encoding either cytosolic or mitochondrial isoforms PPCS PPCDC PMC8572801__F7 Mucin 20 modulates proteasome capacity through c‐Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma HGF POMP MUC20 PMC5204264__F2 Proteome complexity and the forces that drive proteome imbalance MAF ELF3 NRF1 MYC POLI PMC5968632__F2 Pathways significantly enriched for: (A) Loci associated with the vertical cup-disc ratio, cup area and intraocular pressure (P-value <7.0 × 10-6 in the GWAS) MDFI RFX2 THBS1 NOTCH3 DVL3 PMC8471715__F2 Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction NRF1 LPO MYD88 PMC8293073__F5 BMP Signaling in Osteoclast Regulation SMAD4 TRAF6 SMAD1 DKFZp781O1323 PMC6693242__F1 The autophagy pathways in endothelial cells ALG14 PMC12245983__F5 PI3K/Akt/mTOR signalling pathway is activated upon binding of growth factor to receptor tyrosine kinase (RTK), which results in autophosphorylation of tyrosine residues and recruits phosphatidyl-inositol-3-kinase (PI3K) to cell membrane MDM2 PTEN MTOR PMC12245983__F4 Notch signalling pathway upon activation, Notch receptors release signal-transducing Notch intracellular domain (NICD), which moves into the nucleus where it interacts with CSL nuclear proteins, forming CSL-NICD transcriptional complex NOTCH1 HES1 PMC11994588__F3 Liquid-Liquid Phase Separation (LLPS) in Cellular Signal Transduction Pathways APC AXIN1 MTOR PMC8570367__F1 Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment ME1 HEL-S-26 GLS PMC6586788__F1 Hypoxia and aging MDM2 MTOR COCH PMC6820556__F6 Model summarizing the ABeta-induced actin cytoskeletal abnormalities via SHIP2-PI(3,4)P2-ARAP3-RhoA signaling pathway PI3 GSK3B ARHA PMC10915940__F1 Canonical signaling pathway of interferon-gamma STAT1 IFNGR2 JAK1 IFNGR1 PMC12245983__F7 Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models TH MTOR HES1 PMC8505556__F2 Tumour suppressor functions of BAP1, Merlin and p16INK4a/p14ARF proteins PRC1 BRCA2 MYC RAD52 CDK4 LATS1 LATS2 BRCA1 BAX BAP1 PMC12245983__F6 Hedgehog pathway is mediated by ligand HH, upon binding to PTCH the SMO inhibition is weakened, allowing its translocation to plasma membrane leading to HH pathway activation SUFU GLI3 SMO PMC7403459__F1 Two primary pathways produce ceramides in cells: (a) de novo synthesis (b) re-acylation of sphingosine (salvage pathway) CERS3 CERS5 CERS2 PMC9539794__F6 Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice TLR7 IRAK1 MYD88 PMC3884200__F5 Effects of CYP2S1 depletion on mTOR signaling PIK3R1 ULK1 BRAF AKT1S1 PTEN ULK2 HIF1A EIF4EBP1 MTOR RPTOR PDPK1 PRKCA RPS6 VEGFA EIF4E CAB39 TNF IRS1 DDIT4 STRADA RHEB IKBKB TSC2 RICTOR TSC1 IGF1 STK11 PMC7071019__F2 Cellular response: APCs and T-lymphocytes TH APC PMC12245885__F2 Major mechanisms of platelet aggregation COX1 VWF PMC4698632__F8 Telomerase reverse transcriptase acts in a feedback loop with NFKB pathway to regulate macrophage polarization in alcoholic liver disease TLR4 IRAK1 TRAF6 IRAK4 MYD88 CSA2 NOS2 TNF IL1B TERT PMC6070353__F2 Oncogenic Signaling Pathways in The Cancer Genome Atlas AMER1 RIT1 MXD1 NCOR1 KEAP1 ALK SMAD2 PCDHJ MYC GSK3B SMAD4 RB1 CDKN2A FBXW7 FGFR2 CDK6 TAOK1 CCNE1 TAOK2 NF1 FGFR1 MNT MAPK1 NTRK2 PSEN2 YAP1 ERBB3 APC LRP5 LRP6 MLX SFRP5 DKK4 RHEB TSC2 RICTOR TSC1 MAX CDKN1A STK4 AXIN1 STK11 MXI1 MGA CRB1 MAML3 DKFZp781B1423 TGFBR1 JAG2 TGFBR2 PPP2R1A ERF INPP4B KDM5A CHEK2 ARRDC1 ERBB4 NF2 SFRP1 AXIN2 TCF7L1 ARAF KIT WWC1 PDGFRA TAOK3 RAC1 CBL CREBBP EP300 MYCL ERBB2 CRB2 CSNK1D FGFR4 DKK1 MXD4 ACVR2A TLE4 MDM2 ROS1 ZNRF3 SFRP4 CDKN1B DCHS1 FAT1 CDKN1C RET CDK2 ACVR1B TLE2 MLXIP TLE3 IGF1R DNER BRAF EGFR PTEN LATS1 DKK2 MOB1A MTOR RPTOR TEAD2 ATM PTPN11 CDK4 SPEN NCOR2 RNF43 DKK3 NTRK1 FGFR3 NTRK3 MAP2K2 MXD3 WIF1 MAP2K1 hCG_2014051 RAF1 FLT3 SOS1 PMC7981362__F1 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease MTOR IRS1 PMC8945030__F1 Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder RUVBL2 SMG9 NBAS PNRC2 CASC3 DHX34 SGA56M PABPC1 SMG8 UPF2 SMG1 XRN1 RNPS1 UPF3A PMC7981362__F2 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease TSC2 TSC1 MTOR IRS1 PMC6476855__F1 Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation EGF SRC MYD88 MTOR BDNF PMC1088370__F1 Topologies of the three networks CDC20 APC PMC4150610__F2 Interferon-inducible effector mechanisms in cell-autonomous immunity TBK1 HEL-S-62p GBP1 SNAPIN LRRK2 ATP7A GBP2 GBP7 NOS2 DKFZp686F0183 PMC4113681__F1 Representative regulators of the Sprouty cellular content at transcriptional and post-translational level irrespective of the Sprouty isoform and cell type CS MYC GRB2 ARHA RAC1 SIAH2 CRK CDC42 CBL PMC4113681__F2 The Sprouty-mediated regulation of cell proliferation, differentiation, and survival irrespective of the Sprouty isoform and cell type BAD GSK3B MYC GRB2 PTEN CRK CBL PMC11185840__F4 Sphingolipids and complement components signaling in glioblastoma CTSL NLRP3 BCL2L13 CXCR4 S1PR1 SPNS2 PPIL1 STAT3 PMC11185840__F3 Activation of the complement system and its functions CTSL HEL-S-62p NLRP3 ATG16L1 C9 CD46 C7 C6 MTOR HEL-S-130P PMC11185840__F2 Sphingolipid metabolic pathway DES UGT8 CERK PMC9293722__F6 Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARA to restore spermatogenesis in cryptorchid infertile rats TH RARA SYCP3 STRA8 PMC12130998__F7 Supposed mechanism on the dual role of pB318L in viral replication STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 KPNA1 PMC3175563__F6 Proposed mechanism of mechanical stress–induced activation of EGFR pathway in murine tracheal epithelial cells EGF EGFR HBEGF TGFA PMC8572027__F2 Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures MAF NLRP3 TRAF6 IL1B PMC5486373__F1 MiRNAs involved in the regulation of autophagy-related signaling pathways TIGAR ULK1 IGF1R TGFBR2 PTEN MTOR RPTOR UCP2 DRAM1 BNIP3L TFAP2A MLSN2 HMGB2 HMGB1 DUSP4 FOXO3A CDKN1B FUNDC1 RHEB TSC2 RICTOR DUSP5 TSC1 CDKN1A RPS6KB2 CDK2 STK11 APRT SIRT1 CAMKK2 STAT3 PMC2949025__F2 Correlations (Spearman) of biomass growth (biom) and lignin levels with transcript abundance of specific monolignol biosynthetic genes in a interspecific pseudo-backcross pedigree of Populus (family 52-124) CAD PMC7565022__F1 Hedgehog (HH) signaling pathway SUFU GLI3 SMO GAS1 PMC7565022__F4 Protein arginine methyl transferase (PRMT)-mediated modulation of glioma-associated oncogene (GLI) 1 or GLI2 activity PRMT1 NUMB PRMT7 SUFU GAS1 ITCH PMC3561376__F6 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways TRADD APAF1 TRAF2 FADD PMC3561376__F5 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways MOAP1 MYC SNAPC4 STAT5B FOXP3 TACSTD2 STAT1 GADD45B PUM1 SATB1 IL2 ADM CASP8 BAX GADD45G MMP9 IFNB1 CASP3 IL15 CDKN1A UGCG TNFSF10 BCL2 IL2RA CSF1 CSNK2B FADD TERT PMC4514086__F3 Cytosolic RNA and DNA-induced type I IFN signaling pathway and its regulators TBK1 CGAS ATG12 IRF7 TRIM21 GSK3B NLRX1 TRAF3 DDX41 TRAF6 RIGI IRF3 TRIM25 DKFZp686F0183 TRIM32 TRIM56 NMI TRAF2 NLRC3 MAVS IFI16 PMC4644426__F9 Syncytin-1 alterations triggered placental trophoblast cell cycle changes CDK4 CDC2 PMC4299200__F1 De novo and salvage pathway synthesis of dTMP in the nucleus MTR SHMT1 DHFR TYMS MTHFD1 PMC6814454__F2 Substrates of PD enzymes identified by proteomics.(A) The PINK1-parkin mitophagy pathway PINK1 LRRK2 GDI1 PMC4064951__F2 Resistance to BRAF inhibitors: intrinsic and extrinsic mechanisms.Notes: Multiple different mechanisms have been described in resistance to BRAF inhibitors PI3 IGF1R EGFR NRAS CDK4 PTEN MTOR PMC3410756__F1 Folate mediated one-carbon cycle DHFR MTRR TYMS PMC4973992__F6 High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model GRM2 GRM3 PICK1 GRM8 GRM6 SLC38A1 GLS PMC3723115__F2 Canonical TGFB signaling within distinct cell types located in tumor microenvironments SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC8717053__F1 Antiviral effect of antineoplastic agents inhibiting mTOR/PI3K signaling pathway in SARS-CoV-2 infection in cancer patients PTEN MTOR ACE2 PMC4452069__F1 PI3K/Akt/mTOR signaling cascade PTEN MTOR PMC8465097__F5 Differences in Acid Stress Response of Lacticaseibacillus paracasei Zhang Cultured from Solid-State Fermentation and Liquid-State Fermentation MAX MALL HELB MAEA GC GLA PMC9361020__F1 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease ATF4 EIF2A XBP1 PMC8536552__F7 Heat stress inhibits TLR4-NFKB and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium TBK1 NLRP3 TLR4 IRF3 IL1B PMC5969225__F3 Hh–Gli signalling in myofibroblasts DHH IHH PTCH1 SHH SMO PMC8343457__F1 Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease KYNU OTC ASL PMC4410310__F3 Gallus Gallus retinol metabolic pathway from KEGG LRAT RPE65 PNPLA4 DHRS4 UGT2B7 PMC2822520__F7 A working model for endosomal transport involving CLC-5 and KIF3B interaction in polarized cells KIF3B KIF3A PMC8226833__F3 Resveratrol Production in Yeast Hosts: Current Status and Perspectives STS FH HEL107 PMC6650384__F2 Changes in placental signaling in IUGR IGF1R IGF1 EIF2A PMC5708160__F1 Strategies for Comparing Metabolic Profiles: Implications for the Inference of Biochemical Mechanisms from Metabolomics Data GMPR ADA APRT PMC3160197__F1 Crucial role of EGF signalling augments healthy lifespan in worms EGF EGFR MTOR PMC3882527__F5 Ingenuity pathway analysis (IPA)-identified top networks affected by Cd-induced oxidation of proteins HEL-S-49 HEL32 CAP1 ATP1A1 HEL-S-15 DES RHO HEL113 FLNB HEL-S-43 PMC5804490__F3 Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an exploratory study ARHH TPR HDAC1 CD79A PRKCA FYN PLEKHA2 CAMK4 BASH NAPEPLD RCAN3 APP LPP PRKCH CP PMC4896164__F2 Main pathways regulated by the BCR-ABL1 protein MDM2 GRB2 RAF1 CSA2 CRKL GATA2 PMC5444348__F1 The IFN-1 > BID > ROS pathway connects DNA damage with hyper-proliferation and malfunction of haematopoietic stem/progenitor cells (HSPCs) CGAS ATM MTCH2 IRF3 ATR PMC4438523__F3 “Actin Cytoskeleton Signaling” pathway highlighting differentially expressed genes of birds affected with Wooden Breast myopathy CD14 EGF F2R FLNA BAIAP2 ARHA ABI2 DOCK1 CRK GNG12 GRB2 LBP RP2 HEL114 PXN TRIO PMC9405349__F7 GLUT3 Promotes Epithelial–Mesenchymal Transition via TGFB/JNK/ATF2 Signaling Pathway in Colorectal Cancer Cells ATF2 CDH2 PMC6785638__F5 Calcium signaling pathway is overrepresented in the specific differentially expressed genes altered by alfalfa intervention during the preweaning period FAM20C STAC PRKCB PPARGC1A HRC NOS2 RORA PMC7867281__F1 Principal functional interactions between lncRNA HOTAIR and different microRNAs ABL2 GPC5 HLA-G DACH1 CCL2 MTOR NOTCH3 CDK6 CDK4 JAK3 CCL18 AXL PCDH10 STAT3 PMC9453976__F3 Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process MAF TRAF6 IL1B SIRT1 PMC7826734__F1 Role of VEGF signaling in OSCC EGF CCL4 STAT3 PMC11547105__F5 Comparative Metabolomics to Unravel the Biochemical Mechanism Associated with Rancidity in Pearl Millet (Pennisetum glaucum L.) PC PMC6037329__F2 Cholesterol and Bile Acid -Mediated Regulation of Autophagy in Fatty Liver Diseases and Atherosclerosis ABCG8 ABCG5 ABCG1 LDLR ABCA1 TG CYP7A1 PMC9361020__F3 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease TRAF6 IL1B PMC2223843__F2 TLR3 signaling pathways IRF3 TLR3 PMC4887998__F7 Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis STAT1 MSC TLR3 PMC6880379__F3 The Atm-Aim2 axis in neuroinflammation and neurodegeneration ATM AIM2 IL1B PMC8714844__F3 Recent Progress in Lymphangioma TSC2 EIF4E PMC5951909__F8 NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors NDRG3 VHL PMC7352956__F3 Regulation of the Hippo/YAP signaling pathway in non-small-cell lung cancer (NSCLC) EGF NF2 PTCH1 EGFR SMO LATS1 LATS2 PMC7650612__F2 Influence diagram of the molecular interactions implemented in the model EGF ERBB4 HRG ERBB2 ERBB3 GRB2 PMC6109711__F3 cAMP/PKA network HMGB1 HIPK2 CDK5 AMHR2 PPP1R10 P2RY14 PANX2 SNCG HPGD SMARCA4 HNF4A EP300 CREM SIX3 SOX5 PMC3127162__F8 E3 ubiquitin ligase-dependent and E3 ligase-independent roles of Rad18 in tolerance of bulky DNA lesions (left) and replication-associated DSB (right) FANCD2 POLN RAD18 RAD51C PMC7459983__F3 Schematic description of genetic abnormalities (mutations or upregulation) associated with secondary off-target resistance to FLT3 inhibitors HEL-S-26 PIM1 BRAF ASXL1 NRAS PTPN11 FLT3 MTOR AXL STAG2 TET2 CBL PMC8034476__F2 Mechanism and regulatory axis of PTHR1 in osteosarcoma LEF1 DKK1 HAS2 VMP1 PMC8779408__F2 Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development PLK1 CIP2A CEP68 NEK2 PMC5010489__F2 Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses STAT1 TANK STAT2 IRF7 TRAF3 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC6307528__F5 Crosstalk between the Rho kinase and BMP-2 signaling pathways BMP2 ARHA RHO SMAD1 PMC8217435__F1 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 STAT2 IRF7 IRF9 IFNGR2 IRF3 IFNAR2 IFNAR1 TLR3 IFNLR1 STAT1 TYK2 JAK1 IFNGR1 MAVS IFIT1 PMC2585009__F7 HIV-1 Activates Macrophages Independent of Toll-Like Receptors TBK1 TANK IRAK1 TRAF6 IRAK4 IRF3 MYD88 TNF MAP3K7IP1 TLR3 TICAM1 TLR4 TIRAP MAL PMC8103215__F4 Beta-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NFKB Signal Pathway: In Silico and In Vivo FRY CLPS DAP MCU PMC7838888__F1 Representative long non-coding RNAs (lncRNAs) in diffuse large B-cell lymphoma (DLBCL) MYC BUD13 PMC8217435__F3 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 IRF7 TRAF3 IRF3 MYD88 TLR3 MAVS PMC2585009__F4 HIV-1 Activates Macrophages Independent of Toll-Like Receptors HEL2 TRADD MAPK8 MAP3K11 ATF2 TNFRSF6B MAPK3 MAPK14 MAP2K3 STAT1 FGFR1 MAPKAPK5 MAPK1 SP1 RGS4 MAPK7 MAP2K2 TNF MAP3K12 MINK1 PAK1 ADRA2A GRB2 MAPKAPK3 TRAF2 MAPK8IP1 DUSP7 PMC8217435__F4 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 STAT2 IRF7 IRF9 IFNGR2 IRF3 IFNAR2 IFNAR1 IFNLR1 STAT1 TYK2 JAK1 IFNGR1 MAVS PMC2364238__F1 SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer SMAD2 SMAD6 SMAD4 TF CP PMC2895628__F5 Mode of miRNAs that regulate adipogenesis by modulating the canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC6266631__F6 KDM5A function and its expression control in proliferating NPC and differentiating astrocyte CNTF EGF FGF2 GFAP KDM5A STAT3 PMC7753287__F2 Diverse roles of long non‐coding RNAs in viral diseases CXCL10 IFNAR2 MYD88 TNF BCL2L11 IFNAR1 SUZ12 EED TLR8 COX2 TLR7 TLR4 RELA TYK2 EZH2 CSF1 PMC12222062__F8 Oxytropis falcata bunge extract combined with black soybean oil ameliorates DNCB-induced atopic dermatitis-like skin inflammation HDAC3 IL4 CCL27 PMC4000654__F1 Physiological and physiopathological UPR activated pathways in B cells ATF4 EIF2A XBP1 PMC9476852__F6 Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms BAD CD37 HRG HGF LIF EGFR SHE PTEN EIF4E POR BRCA1 RXRA TSC2 NF1 TSC1 BCR RAE1 SI MDM2 SYK AXL RBL2 STAT3 CD19 PMC9607181__F1 Important Hormones Regulating Lipid Metabolism ELOVL6 FASN PMC7795602__F1 Regulatory functions of Mediator complex in biotic and abiotic stress responses MED12 MED13 CDK8 PMC9281252__F4 Molecular perspective on targeted therapy in breast cancer: a review of current status TSC2 TSC1 IGF1R GRB2 PTEN RHEB PMC5438978__F1 Regulation of IL-1/18 production and current IL-1/18 antagonists NLRP3 IL18BP PSTPIP1 PMC4997237__F14 Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures RPLP0 ELF5 RPL35 RPL27 RPL18 RPL4 RPL15 EIF5 ELF3 EIF3F ATM RPS2 EIF2A GRB2 ELF4 RPL27A PMC8000424__F5 Effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling BAD FOXO3A MYC PRB3 PTEN PBX1 CCND2 PRB2 FOXA1 CDK2 BCL2 MCL1 SGK1 PMC4673177__F8 Cerebral endothelial cell function by TGFB in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition PIGF SNAI1 VWF CLDN5 CDH2 PMC3734905__F2 Germline syndromes associated with the Ras signaling pathway.Schematic diagram showing the GM-CSF receptor spanning the phospholipid bilayer NF1 GRB2 CBL PMC7943547__F1 Role model of intracellular HYOU1 in tumor development ATF4 EIF2A HYOU1 PMC3241690__F7 Crosstalk between Nuclear Factor I-C and Transforming Growth FactorB1 Signaling Regulates Odontoblast Differentiation and Homeostasis SMAD2 SMURF2 SMAD4 SMURF1 PMC3967109__F2 Target gene set within Alzheimer’s disease environmental network PITX3 METTL2B TMED10 MMP17 APH1B PMC9133606__F3 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 MMP3 KEAP1 MMP9 NQO1 PMC9239764__F9 ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/Beta-Catenin Signaling Pathway CDH2 PMC9133606__F2 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 PC IL6 NQO1 PMC9602067__F4 Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia EDAR BCR CD40 PMC8740228__F4 Comparative Proteomic Profiling Identifies Reciprocal Expression of Mitochondrial Proteins Between White and Gray Matter Lesions From Multiple Sclerosis Brains ANK2 SET AP2A1 AP2A2 APC NAPB RALA HEL-S-47e PSAP RHO RAC1 PFKM CRK NAPA ST13 CLU TNC ARHG HEL-S-80p VAMP2 AP2M1 ESD GRAP CDC42 PMC8994495__F6 Network diagram of “component-target-pathway” PGR EGFR APP ENG ACHE BAX PMC9641012__F7 Quantitative proteomic analysis reveals the molecular mechanism of the Yesso scallop (Patinopecten yessoensis) in response to Polydora infection PAK1 M6PR BIN1 LPP PMC11540618__F7 Lipid metabolic profiling and diagnostic model development for hyperlipidemic acute pancreatitis PC WAS PMC6627153__F6 PCOS–disease subnetwork 28 MYH9 ATF7 MAPK9 TOX4 BBS2 PTBP1 BBS1 HUWE1 DNAJB1 BBIP1 PPP1R10 TTC8 NFATC2 HEL-S-80p HNRNPD BBS7 STUB1 MDM2 MCL1 JUN HSPA4 CREB5 PMC6627153__F3 PCOS–disease subnetwork 8 RUNX1 SPC24 CDKN1B BRCA1 RPAP3 CREBBP NUF2 NR1i1 KNTC2 URI1 ZWINT NCOA1 KNL1 SKP2 SPC25 NSL1 PMC6627153__F2 PCOS–disease subnetwork 1 RPS13 RPS18 RPS25 RPS5 RPS2 VCAM1 RPS6 RPS26 RPS9 RPS16 RPS3A PMC6627153__F4 PCOS–disease subnetwork 26 HLA-A HLA-E LILRB4 HLA-C PMC4734217__F1 Pim-1 kinase as cancer drug target: An update TSC2 PIM1 BAD SOCS3 CBX3 NFATC1 RELA MYC BCL2 EIF4E SOCS1 STAT3 PMC7996988__F8 Induction of interferonB and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells STAT1 IRF9 IFNAR2 IFNAR1 PMC3218720__F2 Receptors that sense danger signals released from neighboring injured retinal pigment epithelial (RPE) cells HMGB1 TLR4 TLR9 IL1B PMC3393662__F8 Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcERI Aggregation FYN GAB2 LYN SYK LAT PMC514952__F1 Mechanism of endocytic downregulation of RTKs TSG101 EEA1 PMC2841320__F6 ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway via Zinc Finger Transcription Factor CREB PC CCND1 STAT3 PMC6003649__F10 Signalling pathways involved in the intervention effects of PZC, PZD and PZE on TIF SMAD2 APC AXIN1 LRP5 TGFBR2 LRP6 PMC4630171__F12 Proposed model LEF1 WNT4 LRP5 CCND1 PMC9516113__F1 Defining and targeting patterns of T cell dysfunction in inborn errors of immunity ZAP70 CD80 MTOR PMC11526956__F1 Distribution of dNdS values for genes encoding proteins involved in upstream and downstream NFLs across various signaling networks DKK3 LATS1 AXIN2 LATS2 SOCS1 PMC3388714__F2 Layers of DC-mediated tolerance IL10 CD80 TNF PMC11814332__F9 Schematic depicting the role of CerS6 in ceramide metabolism and innate immune responses TBK1 CGAS CERS6 PMC8345475__F1 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics SUFU SHH SMO PMC3423345__F2 Early Second Trimester Maternal Plasma Choline and Betaine Are Related to Measures of Early Cognitive Development in Term Infants HEL-S-182mP CHDH DHFR PMC6423516__F2 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss ULK1 ATG16L1 TFEB ATG12 LYN DKFZp686F0183 PMC8345475__F2 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics IRF4 IRF6 PMC9692235__F6 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation FOXC1 TLE3 CYLD TLE4 MYC BCL2 HES4 PTEN FLT3 HDAC1 TLX1 HES1 PMC3288319__F4 Phytoestrogens on ECs and VSMCs GC ARHA PMC6423516__F3 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss CRY1 ULK1 CREB1 SIRT3 PINK1 TFEB SIRT4 SIRT5 PGC FXR1 STK11 SIRT1 PER2 PMC8146591__F2 Glutathione S-Transferases in Cancer MTOR TRAF2 HEL-S-22 PMC9692235__F2 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation ERBB2 MYC CCND1 FOXG1 CHAC1 BRCA1 PMC7900568__F1 cGAS-STING pathway and type-I IFN signaling TBK1 STAT1 CGAS IRF3 TYK2 IFNAR2 JAK1 IFNAR1 PMC3507808__F1 Metabolites and their metabolic pathway networks measured by the Arg/Thiol Redox Metabolomics Assay HEL-S-61p CIT ASL PMC3863464__F6 Putative CA-mediated inhibitory pathway of inflammatory signaling events TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC6213474__F2 Sonic Hedgehog (SHH) molecule or SHH secreted on extracellular vesicles (EVs) mediated functional improvement of endothelial progenitor cells (EPCs) SUFU SHH ARHA PMC9569554__F4 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair TSC2 EPO MSC MTOR EPHB4 PMC12188669__F2 YOD1 in regulating multiple cellular signaling pathways SMAD2 TRAF6 YOD1 NEDD4 ITCH PMC6213474__F1 Canonical and Non-Canonical Sonic hedgehog (SHH) signaling pathway in endothelial progenitor cells (EPCs) and endothelial cells (ECs) MMP2 SUFU PTCH1 SHH SMO ARHA PMC9569554__F3 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair EPOR FGF23 EPO RUNX2 PMC4323349__F1 Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer GCLM GCLC CYP2E1 ALDH2 PMC9569554__F5 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair BMP2 MSC LRP5 LRP6 TNF SMAD1 DKFZp781O1323 PMC12188669__F6 Disease signaling by YOD1: potential implications for therapeutic strategies NLRP3 TUG1 CDC2 YOD1 ITCH PMC12188669__F5 Roles of YOD1 in Diseases MYH9 PML INHA MDM2 YY1 RIPK2 YOD1 NOD2 NEDD4 ITCH PMC9569554__F2 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair MMP3 ADAMTS4 TWIST2 RUNX2 DLL4 NRP1 PTGS2 MMP9 NOS2 NRP2 SOX9 PMC6367275__F2 Schematic and simplified representation of the several components of the IGF-1/PI3K/AKT/mTOR pathway discussed in this review BAD IGF1R IGF1 GRB2 DEPTOR PMC7536068__F1 Schematic depicting an overview of the autophagy pathway and mechanisms used to manipulate autophagy ATG12 ATG3 DKFZp686F0183 PMC5928262__F1 Ang/Tie pathway regulation of vascular stability TRPC1 ASB1 SRC ARHA RHO RAC1 FOXO1 PMC2735125__F7 HP1 Proteins Form Distinct Complexes and Mediate Heterochromatic Gene Silencing by Non-Overlapping Mechanisms AGO1 CIRSR CHP2 CHP1 PMC2408433__F1 Glucose transport regulation by the Akt/TSC pathway TSC2 TSC1 MTOR RHEB PMC7283559__F1 C-type lectin receptor signaling in TB and HIV MRC1 APC MYD88 PMC7112240__F1 Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth AIP PMC8699653__F2 Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy BAD ATM PTEN ATR PMC3909204__F1 EGFR and FGFR Pathways Have Distinct Roles in Drosophila Mushroom Body Development and Ethanol-Induced Behavior EGFR RHO PMC8446437__F2 Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation IDO1 AHR IFNG PMC8222670__F4 Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition EGF COX2 ZEB2 GSK3B ARHA PMC4820400__F2 Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease BACE1 MMP9 PMC4275944__F5 A schematic linking the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation to status epilepticus (SE) pathogenesis NLRP3 TLR4 IL1B PMC6412771__F2 De novo synthesis of NAD(P) from tryptophan, nicotinamide and nicotinic acid NAMPT HEL-S-90n KYNU KMO AFMID NADSYN1 PMC7022881__F1 Two signaling pathways that respond to extracellular glucose in Saccharomyces cerevisiae GBP1 GBP2 PMC6279876__F4 Schematic model of HPV-driven carcinogenesis CDK4 E2F3 SIRT1 CDK6 PMC9634088__F2 Immune defenses of the mammary gland epithelium of dairy ruminants TLR4 NOD1 TRAF3 TRAF6 IRF3 MYD88 TLR1 IL1B NOD2 TLR3 TIRAP CD36 PMC6557761__F5 Evaluations on Substrates of FBXL Family E3s(A and B) Known (red edge) and predicted (gray edge) ESIs for FBXLs CTBP2 CCNA2 PRKCZ E2F4 HEL-S-1 CSNK2A1 CRY2 NBN UBE2T HSPD1 NUDT21 CCNE1 XRCC5 TAF15 TOPBP1 MDM2 BHLHE41 FBXL17 HSD17B4 ANAPC7 NUP214 DOCK1 FBXW11 DDB1 FBXW8 CKS1B EMG1 MCM6 RASSF1 GTF2E1 CDKN1A SUFU CDK2 SLC3A2 SNRPB2 SMN1 NFKBIE TFDP2 SNRPA DNAJC10 FBXL12 CD81 FZR1 FBXL3 POLR2A CDC2 DDX5 PPP2R2A RBL2 FBXL15 CRY1 POLR2K POP1 RAC1 SMURF1 FBXL8 CAMK1 GTF2F1 FBXL6 CASP3 USE1 NFKBIA CREBBP EP300 PIAS1 TOB1 DAB2IP MAPKAPK3 RAN PMC10302777__F2 Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods HEL-S-61p PMC3747540__F1 Emerging signaling pathways in hepatocellular carcinoma HHIP TLR4 NF2 ARID2 SMO LATS1 LATS2 PMC6627996__F3 TLR4 signal pathway in oxidative stress CD14 TLR4 IRAK4 MYD88 TIRAP PMC3434202__F1 Suppression of Cancer Progression by MGAT1 shRNA Knockdown MGAT5 MGAT1 MGAT2 PMC6627996__F2 TLR2 signal pathway involved in oxidative stress HEL-S-44 MYD88 TIRAP PMC3185699__F1 Proposed signaling pathway to the actin cytoskeleton during HIV-1 entry in T lymphocytes ITK CXCR4 ARHA PMC6109047__F7 Pictorial Abstract SOX2 MMP2 MMP9 GSK3B CCND1 DVL2 PMC5142237__F1 The canonical and noncanonical pathways by which the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is activated and elicits an inflammatory response NLRP3 TLR4 IL1B PMC5470118__F3 Canonical cannabinoid receptor (CBR)-mediated, G protein-dependent signaling pathways SRC MTOR STAT3 PMC5144105__F2 Signal transduction pathways in cranial development FGF4 RUNX2 LRP5 FGFR3 SMAD4 LRP6 ERF TCF12 FGFR2 WNT3 FGFR1 WNT3A TWIST1 FGF3 MSX2 FRAT1 SMAD1 DKFZp781O1323 PMC9293517__F10 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis PC TNF PMC3004331__F3 Differential host transcriptional responses within the acute-phase response pathway in r1918-infected WT, TNFRKO, and IL1RKO mice at 1, 3, and 5 dpi FGA HEL-S-62p HRG HAMP TRADD TRAF6 MYD88 MTOR SERPINA3 HEL-S-78p HP F2 AHSG LBP VWF ECSIT SERPINA1 APOH CP TF STAT3 PMC3541025__F1 Autoinflammatory Disease Reloaded: A Clinical Perspective NLRP3 IL1R1 RAC1 PSTPIP1 PMC10540234__F8 Sulforaphane and bladder cancer: a potential novel antitumor compound RELB CD40 LTBR PMC6059697__F11 p53 signaling pathway obtained from the DAVID Database TSC2 SIAH1 PERP ATM MYC MDM2 GDNF PTEN ATR RFWD2 BAX PMC3293632__F1 Control of the EGFR pathway and cell cycle entry by miRNAs STAT1 EGFR RB1 STAT3 PMC9372658__F1 TAK-242 ameliorates epileptic symptoms in mice by inhibiting the TLR4/NFKB signaling pathway TLR4 WAS PMC8231946__F2A Proliferation, dissemination and proteasome inhibitor resistance AREG CXCR4 PMC7697684__F3 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance PFAS NADK ADSL UMPS PAICS HEL-S-70p CAD DHODH HEL107 PGAM1 HK2 PMC4974115__F1 Complement in disease: a defence system turning offensive HEL-S-62p C4B_2 CD46 CR1 CLU PTX3 CD81 C5AR1 CD59 BCR FH VTN CD55 CR2 C1S CP CD19 PMC7697684__F5 Major steps of glycolysis and direct and indirect regulation of glycolytic enzymes (in light blue) via Akt NADK PGM2 PFKFB2 ENO1 HEL107 PGAM1 HEL-S-133P HK2 HEL-S-68p HEL-S-162eP PMC4057522__F8 Possible mechanism implicated in tamoxifen resistance in the TAMR cell line model SOX3 SOX13 CCND1 SOX9 SOX4 PMC9461661__F4 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer UCHL5 USP15 GPX4 LPCAT3 FACL4 KEAP1 SLC7A11 USP35 USP25 RBX1 USP11 USP14 TF BAP1 PMC9495541__F6 Cynanoside F Controls Skin Inflammation by Suppressing Mitogen-Activated Protein Kinase Activation LORICRIN TSLP IL1B PMC8634166__F8 Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation IL16 TLR4 MYD88 HK2 PMC9461661__F3 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer HERC2 GPX4 LPCAT3 FACL4 KEAP1 TRIM46 TRIM21 HEL110 RBX1 VDAC3 TRIM26 NEDD4 KLHDC3 RNF139 MDM2 IBRDC1 ACSL3 MIB2 TF SKP2 PMC4383535__F3 Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation HEL-S-30 TRH HEL-S-87p ADM PMC3077649__F7 Model of Egr-1/GGPPS/Erk1/2 pathway regulating insulin resistance in hyperinsulinism EGR1 GRB2 SHE SOS1 PMC8209548__F8 Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction PAK1 FLNA RAC1 CDC42 PMC4197584__F7 Pathway interactions regulating midgut patterning NODAL SOX17 FOXH1 PMC3476735__F5 Metformin, an anti-diabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway TSC2 TSC1 IGF1 CCND1 IRS1 RHEB AKT3 PMC8034938__F7 Celecoxib attenuated ZD-promoted tumorigenesis through suppressing inflammations PI3 IL16 CXCL5 CXCL2 PMC7906116__F8 Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity TLR4 SFN MYD88 PMC6306737__F1 Metabolic pathway of lipid metabolism in muscle CHAD CPT2 ACAD9 PMC3945337__F1 Quantifying the Sources of the Essential Sugar Mannose♦ PMC3871247__F6 TTC7A mutations disrupt intestinal epithelial apicobasal polarity TTC7A ARHA RHO PTEN PMC8965480__F9 Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas CSF1R AXL CD68 PMC4214092__F1 Senescent cells in ageing ATM CDK2 CDK4 PDP2 ATR CDK6 PMC5103168__F6 Pre‐ and Post‐Natal Stress Programming: Developmental Exposure to Glucocorticoids Causes Long‐Term Brain‐Region Specific Changes to Transcriptome in the Precocial Japanese Quail NPR3 TIMP3 CACNA2D3 TACR1 MT1B STAB2 PSG5 PMC7242738__F3 KEGG pathway for TNFA (bta04668) with the annotated DEGs in our results between Besnoitia besnoiti-infected BAEC cells at 32 hpi vs EDN1 CS FOS TNF TRAF2 JUN FADD MLKL PMC7697684__F8 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance ATM USP14 PARP2 RAD51 PARP1 ACLY ATR BRCA1 KDM5A UBE2S PMC7697684__F7 Fatty acid synthesis and Akt-mediated regulation of lipid metabolism via phosphorylation of its targets and SREBP-dependent expression of various proteins (in light blue) LDLR ACLY PMC7472444__F6 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase OMP PPARGC1A NR1C1 PMC7472444__F5 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase CTH PCK1 ARG2 HEL-S-53e ASPA ASS1 HEL-S-133P PMC7472444__F4 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase PCK1 ENO2 PFKP HEL-S-133P HK2 HEL-S-281 PMC7377904__F2 Activation of the Wnt canonical pathway induces Beta-catenin-regulated gene expression APC GSK3B PMC7372973__F3 JAK-STAT signaling pathway STAT1 IL13 STAT4 IL2 TYK2 JAK3 IL6 JAK1 IFNG STAT3 PMC2707271__F5 Proposed mechanism for MAP4K3 cell death signaling BAD MAP4K3 EIF4B BAX PMC7377904__F3 Vitamin D interferes with Beta-catenin induced gene expression via different pathways in different cell types NR1i1 LRP5 PMC5070418__F1 Signaling pathway involving mTORC1 NF1 TSC2 ULK1 TSC1 RYK PTEN EIF4E RHEB PMC8790935__F2 NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling NLRP3 TXNIP MCU PMC3823708__F9 NFKB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma SOCS3 LIF JAK1 STAT3 PMC7676916__F10 MiR-204-mediated regulatory mechanism in chicken granulosa cell (GC) proliferation, apoptosis, and autophagy ULK1 MTOR MLSN2 FOXK2 PMC10748092__F2 Colorectal Cancer Stem Cells and Targeted Agents SOX2 EPCAM CD44 SMO GPR49 MTOR STAT3 CD24 PMC6890721__F4 Caffeine, theanine and catechin biosynthetic pathways in plants, and expression patterns of genes related to quality metabolites in ‘Xiaoxueya’ leaves GAD2 CS F2 GC AIDA XDH PMC9284495__F7 Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1A/TGFB1/SMAD pathway SMAD2 SMAD4 PMC7368941__F6 Function of podocyte injury is closely related to morphological changes ULK1 ULK2 MTOR SIRT1 PMC3652647__F7 Schematic model of probable pathway of refractoriness of interferonB signal TBK1 NOD1 IRF3 PMC3580164__F3 Transcriptional integration of mitochondrial biogenesis ULK1 YY1 NR1C1 SIRT1 SIRT3 PMC9036358__F1 Cyclic GMP and PKG Signaling in Heart Failure RGS4 NPS PGC TRPC6 RGS2 RYR2 PMC11853349__F7 Protective mechanism of dapagliflozin in sepsis-induced cardiomyopathy: The SIC model was established by animal experiments PRDM10 STAT3 PMC6985539__F1 Targeting molecules common to pathways promoting angiogenesis and neuroendocrine phenotype in prostate cancer RET CREB1 ENO2 HDAC2 ONECUT2 RB1 AURKA FOXA2 PMC5606335__F6 Oxygen-dependent regulation of antioxidant production by HIF1 PSAT1 SHMT1 PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH MTHFD1L PMC10815547__F8 Scheme of the ginsenoside biosynthetic pathway in ginseng according to Li et al SST GRB2 MVK F11 NOTO MVP PMC6710771__F1 Ang/Tie2 signalling in the diabetic eye, including crosstalk with the VEGF pathway GSK3B SRC BCL2 RPE BAX PMC7072244__F2 ALK-EGFR-AKT pathway promote STING-dependent innate immune response in macrophage during bacterial sepsis TBK1 CGAS EGFR IRF3 PMC2690586__F1 Maintenance of the G1/S DNA damage checkpoint in the presence and absence of Cdk2 ATM CDK2 CDC2 ATR PMC8703190__F1 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain SAG SHH SMO PMC6757314__F3 KEGG pathway analysis of the differentially expressed genes in head and neck squamous cell carcinoma SLC1A1 PCK1 COL3A1 ATP1B4 COL1A1 AOX1 LAMB4 COL4A6 AQP7 COL12A1 opn UGT1A10 COL1A2 COL6A1 UGT1A8 COL2A1 XB ADH1C LAMC2 XPNPEP2 COL27A1 COL5A2 LAMA3 PLIN4 CYP2E1 HEL-S-4 LAMA1 COL22A1 MGST1 CYP3A4 PLIN5 COL13A1 IBSP CHAD ALDH3A1 PPARG COL10A1 COL4A2 COL4A1 COL4A5 PMC5900771__F1 Methylation and glycerolipid metabolism in yeast PC TG PMC8703190__F2 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain SAG SMO BDNF PMC6566801__F2 Possible mechanisms releasing mitochondrial components into the circulation TBK1 NLRP3 PINK1 CGAS IL18 IFNA1 TLR9 IL6 OPA1 PMC5388800__F1 Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging TNLG8A CD34 BMF IFNG PMC7778590__F5 Targeting YAP for PDAC therapy LATS1 RHO LATS2 PMC11674716__F7 KEGG network diagram of the adipocytokine signaling pathway LEP POMC SOCS3 TRADD NPY AgRP LEPR MTOR TRAF2 STAT3 PMC7778590__F1 Core components of the Hippo pathway in mammalian cells NF2 VGLL4 LATS1 LATS2 PMC8144525__F8 Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury EPO GRB2 RAF1 PMC9419985__F3 Hematopoietic Stem Cells in Wound Healing Response TLR4 GFI1 MYD88 TF PMC9419985__F2 Hematopoietic Stem Cells in Wound Healing Response TLR4 GRB2 SRC MYD88 TF PMC4909440__F1 Mechanistic consequences of PREX2 truncating mutations IGF2 PTEN RAC1 CDKN1C PREX2 PMC9395635__F1 Road testing new CAR design strategies in multiple myeloma CD34 IL2RB PMC7241259__F2 Wnt pathways ATF2 GSK3B LRP5 LRP6 ARHA ROR2 PMC8550922__AF1 Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway AGO2 KIN CYP2E1 CDC42 PMC7037240__F1 GM-CSF–IRF4–CCL17 pathway in inflammation and pain CCL17 TNF IRF4 PMC7709111__F5 Three top-scoring interaction networks of highly abundant aqueous humor proteins SPARC BTD FCGBP APOD ORM1 PRELP CFI C9 A2M MMP2 HEL-S-2 GC C7 SERPING1 SERPINA1 B2M NPC2 FGA SCG2 CHGB RELN HRG PLG LYZ APC IGFBP7 LCN2 PON1 PSAP SPARCL1 AFM KRT2 HEL-S-22 TIMP1 HSPG2 ORM2 F5 VTN C8G HBB IGFBP2 ALDH3A1 APOH IGFBP6 HABP2 AGRN HEL-S-62p APOA4 C4B_2 CLEC3B CUTA A1BG C4A AMBP ITIH4 HMFT1766 ITIH2 PRNP DAG1 SERPINC1 UBC HBA2 CFD F2 SCG3 CFH SERPIND1 opn APP RBP4 MYOC KNG1 KRT1 APOA2 KRT10 CFB NEGR1 PCOLCE GUGU HEL-S-130P IGFBP5 PS1TP5BP1 SPON1 OPTC C8A GPX3 RBP3 HP VGF CD22 AHSG C6 KRT9 SERPINF2 TGFBI PMC5549331__F1 Molecular pathways of macrophage polarization STAT1 MRC1 TLR4 CXCL10 IRF3 MYD88 IRF4 STAT3 PMC6070815__F5 Pathways of the annotated DE genes and lincRNAs in the adipose tissues of high- and low-FE pigs LIPE ABCB4 NR4A3 ATP2B2 VIPR2 ELOVL7 GNAS PDE1A ABCD2 PMC11906677__F7 Mechanism of PP suppressing NLRP3 inflammasome by targeting CK1A–Beta-catenin–NFKB–NRF2–mitochondrial OXPHOS pathways during bacterial infection NLRP3 GSDMD PMC4178922__F2 Fgf7 and Fgf10 signaling via Fgfr2b controls proliferation versus chemotaxis, respectively SH3BP4 FGF10 FGF7 PMC4017039__F1 Intracellular signal propagation of human toll-like receptors and corresponding ligands in innate immunity CD14 TLR5 TLR7 TLR4 TLR9 IRAK1 TRAF6 IRAK4 MYD88 TLR1 TLR3 TIRAP PMC5949531__F2 Nerve growth factor (NGF) signaling cascade NGF SHE TRAF6 ARHA CRK PMC2638772__F9 Model whereby increased Fgfr3 signaling in chondrocytes causes premature synchondrosis closure and unification of ossification centers BMP2 BMP7 MAPK1 PMC2869094__F1 Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia FOSL1 APC GSK3B LRP5 MYC LRP6 CCND3 WIF1 DVL1 CCND2 LEF1 PPP2CA CCND1 DVL2 JUN BCL9 TLE2 ITCH PMC3788328__F1 Calcium and calcium-permeable channels in the control of autophagy TRPV2 TRPV5 TRPV6 MCU TRPM2 MTOR TRPV1 TRPM8 PMC4496399__F6 NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib NGF CD44 ARHA PMC5841365__F2 Macroautophagy: an overview of the molecular pathway and mutations associated with congenital disorders of autophagy NPC1 ULK1 ATG12 ATG3 KIAA1632 WDR45 SPG11 ATG10 ATG14 DKFZp686F0183 SNX14 PMC7904579__F7 Applying Genome-wide CRISPR to Identify Known and Novel Genes and Pathways that Modulate Formaldehyde Toxicity FLCN LAMTOR3 GSK3B LRP5 RNF152 EIF4E MTOR DEPTOR RHEB TSC2 TTI1 TSC1 LAMTOR2 LAMTOR1 SLC3A2 RRAGA SESN2 EIF4B SKP2 PMC3940969__F1 Cytokine signaling pathways in brain preconditioning CCR2 TRADD TRAF6 CCL2 MYD88 TRAF2 PMC7206068__F5 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses TBK1 CGAS TRIM21 IRF3 MYD88 TLR3 IFNG TRIM23 TRIM14 TLR4 TRIM38 TRIM32 USP14 TIRAP PMC7206068__F3 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses ULK1 TRIM16 TRIM21 AMBRA1 TRAF6 TRIM6 ATG101 TRIM17 TRIM59 TRIM65 IFNG TRIM49 TFEB TRIM32 TRIM28 TRIM37 PMC9710844__F7 Graphical abstract of DDOST-regulated MITA-mediated signaling pathway TBK1 CGAS IRF3 PMC5556685__F2 Working model illustrating the potential impact of milk exosome-derived miRNAs on the expression of p53 TSC2 IGF1R IGF1 PTEN FOXO1 BAX PMC8005985__F5 Regulatory function of main lncRNAs related to cardiomyocyte maturation MCM3 CRIP2 YAP1 DACH1 PHB2 FIS1 PMC8005985__F4 Regulatory effect of H19-LncRNA in cardiomyocyte maturation GSK3B TESC SOX6 PMC316782__F1 Genetic pathways of sex determination in D PMC2664743__F4 Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity BDNF PMC8294626__F8 H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease LRP5 LRP6 ATP6AP2 AXIN2 EN2 PMC7399735__F6 Gene-to-gene network of Col-0 vs DCD AGO1 AGO2 NPR3 HEL-S-44 ARF3 PMC6701373__F2 Transforming growth factor-Beta- (TGF-Beta-) induced EndoMT SMAD2 SMAD4 CDK4 MTOR PMC4033420__F1 Colorectal cancer MSI and CIN signaling pathways modified from KEGG database CASP3 SMAD2 APC TGFBR1 CASP9 SMAD4 BCL2 DCC BAX PMC3571329__F7 Proposed metabolic model for syntrophic growth of D POR HEL-S-133P PMC7151181__F3 Signal transduction pathways activated by GlcNAc TEC PMC12196518__F1 Mechanisms of LSEC defenestration and the role of defenestrated LSEC in liver fibrosis POFUT1 VCAM1 KLF2 RHO LPA TNF STAT3 PMC4324503__F5 Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation TLR4 CFTR PMC11312279__F9 Ceramide Ehux-C22 Targets the miR-199a-3p/mTOR Signaling Pathway to Regulate Melanosomal Autophagy in Mouse B16 Cells ULK1 MC1R MTOR DKFZp686F0183 PMC8276988__F2 Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy ATG16L1 ATG12 PANX1 VAMP7 DKFZp686F0183 BAX PMC5131917__F8 PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress RAD18 SDE2 PCNA PMC12209307__F9 Diagram of the mechanisms by which tricin fighting against KRAS-mutant NSCLC FOSB SRC JUNB IFNG PMC9588367__F8 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis MPV17 F10 EPO P2RX7 EGFR ALB ALOX5 POLG TYMP CCL2 ACHE MTOR PPBP COX2 PLAT KDR CDC2 SELE IL10 NAAA KIT C10orf2 CYB IL6 AURKA IDO1 ND6 CNR2 COX3 CYP3A4 ERBB2 CDK2 PIK3CA SYK PMC9288447__F1 Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit FGFR3 FGF17 PMC9588367__F5 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis PIK3CD F10 EPO P2RX7 ALB MAPK14 CCL2 IFNG NLRP3 COX2 FLT1 KDR RAD51 NAAA DGUOK C10orf2 CNR2 CYP2C9 F5 CDK2 EGFR POLG TYMP ACHE MTOR PPBP PLAT CYP2C19 ELANE CDK4 SELE RORC IL10 KIT LRRK2 CYB IL6 AURKA IDO1 RRM2B ND6 COX3 CYP3A4 ERBB2 ZAP70 PIK3CA SYK FLT3 STAT3 PMC5413598__F1 Hippo signaling pathway HEL70 NF2 VGLL4 LATS1 LATS2 PMC4092141__F1 cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis PI3 SKI PMC7686857__F1 Mitochondrial iron co-factor biosynthetic pathways are reliant on FXN iron chaperone function FECH ISCU PMC4705527__F5 Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin CIT IPP MAL PMC5964135__F2 Proposed signaling cascades recruited in the setting of remote ischemic conditioning based on available data BAD BAX PMC3039924__F1 Insulin-like growth factor receptor 1 (IGF1R) signaling pathway and potential mechanisms of resistance to IGF1R blockade (red asterisks) RICTOR BAD TSC1 EGFR PTEN EIF4E MTOR IRS1 RHEB IGF2R INSR PMC9616789__F10A Spatial Analysis of Neural Cell Proteomic Profiles Following Ischemic Stroke in Mice Using High-Plex Digital Spatial Profiling BAD CASP12 ALK APC MCU ACHE TNF POR CASP3 SI LPL APP CAD ATR ATG14 COMP BPI FADD PMC5868625__F6 Summary of the inhibitory effect of ILQ on PI3K/Akt/mTOR pathway members.Abbreviation: ILQ, isoliquiritigenin GSK3B CCND1 MTOR PMC9433414__F3 Interaction between the circadian clock and mTOR-related signaling transduction pathways TBC1D7 PTEN EIF4E DEPTOR IRS1 VIP RHEB SIK1 MLST8 TSC2 TSC1 GRB2 PER2 PER1 PMC11913671__F2 Inflammatory pathways in glomerular disease STAT1 NLRP3 STAT4 PTPN11 LAIR1 STAT3 PMC5243181__F1 Differential gene expression in PPAR signaling pathway UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC8396474__F1 Redox Signaling and Sarcopenia: Searching for the Primary Suspect FOXO3A F3 MTOR SIRT1 FOXO1 SIRT3 PMC8615799__F9 Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma PC HGF CD44 RHOV CDC42 PMC3722447__F1 Defects within components of the ECM and the TGFB signaling pathway leading to various HCTD SMAD2 TGFBR1 TGFBR2 SMAD4 TF PMC4211700__F4 PKCD and θ Possibly Mediate FSH-Induced Mouse Oocyte Maturation via NOX-ROS-TACE Cascade Signaling Pathway AREG EGFR FSHR PMC2945562__F8 Summary of signaling pathways for cPLA2A activation and eicosanoid production stimulated by engagement of C COX2 COX1 SYK MYD88 PMC8616420__F3 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer CASP3 PLK3 PTEN HIF1A MTOR CASP8 FADD PMC8616420__F2 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer ATM BRCA2 CCND1 RAD51 PMC2662697__F6 Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88 Dependent and Independent Signaling and is Reciprocally Modulated by LXR Activation CD14 TLR4 IRF3 MYD88 ABCA1 CD36 PMC5585386__F6 Schematic representation of a B DGAT1 PC DGAT2 LPA HEL-S-5 PMC6709694__F4 Integration of HTS and CTD informs disease-pathway connections TH TNF AMT PMC8201405__F4 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms TBK1 CGAS TRIM32 IRF3 PMC8201405__F3 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR3 PMC3382968__F1 The four principal manifestations of immunological autophagy NLRP3 TRAF6 AIM2 PMC3460045__F3 Pathological functions of LOX family oxidases during cancer progression and metastasis GSK3B VEGFA HIF1A CRK PMC9011227__F1 Lipid rafts in persistent Helicobacter pylori infection: a narrative review STAT1 CXCL9 JAK1 PMC7802409__F3 Microglia damage to neurons after encephalitis leads to neurological complications in survivors IL16 PELI1 P2RY13 IFNG PMC12157993__F10 TV-EV-induced inflammatory cascade in host cells NLRP3 CXCL1 MICB TRAF3IP2 TLR3 PMC10915131__F6 Working model for the role of the mechanistic target of rapamycin complex 1 (mTORC1) and its regulated macroautophagy in the induction of cardiomyocyte necroptosis by large doses of isoproterenol (ISO) RIPK1 TFEB RIPK3 MLKL PMC4657734__F2 Smad complexes can cooperate with transcription pathways in the control of gene expression in epithelial-mesenchymal transition RBPJ FOXA1 SMAD2 ZEB2 GSK3B SMAD4 SHH SMO FOXC2 LAT FOXA2 PMC4657734__F1 TGF-Beta-activated non-Smad pathways in epithelial-mesenchymal transition SMAD2 ATF2 SMAD4 ARHA RAC1 SMURF1 TRAF4 CDC42 PMC12090520__F9 Mechanism by which F1929-1458 activates anti-tumor immunity HMGB1 CGAS NFKB1 CCR7 CD80 PMC8633599__F2 Molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development GRPR NPPB ITCH PMC3685413__F2 SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia CPSF2 CD14 CCNB3 CREBBP CHD8 MYC RYK IRAK4 SPOP FANCA MSH4 PMC6131564__F4 Sub-pathway of the HIF-1 signaling pathway identified on the basis of sub-pathway strategy EGLN3 IGF1R MAP2K1 EP300 EGFR MAP3K14 MAPK1 EIF4EBP1 HIF1A ZNF761 PMC9449579__F3 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy SQLE SOAT2 GSK3B MDM2 CYP24A1 SOAT1 PTEN MTOR PMC6131564__F3 Sub-pathway of chemokine signaling pathway identified on the basis of sub-pathway strategy SHC2 GNB2 c-fgr MAP2K1 GNB5 NRAS GRB2 MAL PMC8997990__F6 FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells SFTPC FOXO1 SFTPB PMC6131564__F2 Sub-pathway of the MAPK signaling pathway identified on the basis of sub-pathway strategy MAP3K1 MOS MAP2K1 MAP2K4 MAPK4 FOS MAP2K3 PMC9449579__F1 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy SQLE FDPS FDFT1 IPP HMGCR PMC8122029__F7 Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment IRF9 CYC1 PMC9588367__F3 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis PIK3CD MPV17 F10 EPO MAPK8 P2RX7 ALB MAPK14 ALOX5 HSPD1 CCL2 PTGS1 IFNG NLRP3 FLT1 FGFR1 KDR RAD51 DGUOK AURKB CNR2 CYP2C9 F5 CDK2 TBK1 EGFR POLG TYMP ACHE MTOR PPBP PLAT PABPC1 CYP2C19 ELANE CDK4 CDC2 PRKDC SELE RORC IL10 KIT LRRK2 PARP1 IL6 KLKB1 SLC25A4 CHEK1 AURKA IDO1 RRM2B CYP3A4 ERBB2 PIK3CA SYK RAF1 FLT3 STAT3 PMC9588367__F2 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis RORC CNR2 F10 PLAT CYP2C9 CYP2C19 ZAP70 POLG TYMP ACHE AURKA PMC5846366__F2 Molecular targets of natural compounds in breast cancer pathway COX2 COX1 FADD PMC11735026__SF4_3. GnRH signaling pathway: The KEGG graph shows the involvement of ADCY3 and MMP2 genes driving the GnRH signaling pathway MAPK8 EGFR MAPK14 FSHB MAP2K3 MMP2 ATF4 PTK2B SRC JUN GNRHR EGR1 MAP3K1 MAPK7 HBEGF CGA HRAS LHB ADCY3 CALM1 GNA11 PLCB2 MMP14 GRB2 GNAS RAF1 SOS1 CAMK2A CDC42 PMC3559784__F5 The Carcinogenic Liver Fluke, Clonorchis sinensis: New Assembly, Reannotation and Analysis of the Genome and Characterization of Tissue Transcriptomes CTSF RAN COMP PMC4898879__F7 Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light CORT OPN4 PMC7341904__F1 Upregulation of the MAPK pathway in tumor cells leads to proliferation and progression of thyroid cancer RET BRAF MTOR SSTR2 PMC8353273__F2 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases CGAS ENPP1 ULK1 PQBP1 USP21 RNF185 MUL1 SENP2 ULK2 SAR1A RNF5 SEC24C AMFR SENP7 TTLL6 TTLL4 ZCCHC3 NLRC3 IFI16 TRIM41 DDX41 TRIM29 TRIM14 INSIG1 TRIM38 RNF26 TRIM32 TRIM56 PMC8766746__F5 Robo2 and Gen1 Coregulate Ureteric Budding by Activating the MAPK/ERK Signaling Pathway in Mice RET GREM1 GEN1 GDNF ROBO2 SLIT2 ETV5 PMC3806315__F4 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle HEL-S-182mP GLDC AMD1 PHGDH PMC8353273__F1 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases TBK1 CGAS IRF3 PMC8821531__F6 T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects ATM INS PMC6738402__F1 Role of Fyn in misfolded Alpha-synuclein (ASyn)-mediated NLRP3 inflammasome activation NLRP3 FYN CD36 PMC11942496__F3 Function of the MAPK Signaling Pathway in Cardiac Hypertrophy BMP7 MAP2K3 MTOR PMC3806315__F2 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle HEL-S-61p DHFR GLDC PMC2778737__F4 Nephron development and cell lineages RET CITED1 WNT4 TLE4 SIX2 FOXD1 PMC9179380__F2 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas HEL-S-62p KIT RAG1 CD44 C6 FLT3 RAG2 FOXP3 PMC9179380__F1 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas TH IL21R AHR SMAD2 CD40 IRF4 FOXO1 GATA3 ICOS BCL6 FOXP3 PMC8122951__F2 Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia NOTCH4 CCR2 CX3CR1 CX3CL1 CCL2 NOTCH3 PTX3 BMP4 MVD VCAM1 CD163 CXCR4 MSC CXCL12 PMC3158866__F1 Toll-like receptor signaling pathway HMGB1 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR4 TIRAP PMC5678904__F3 TGF‐B/SMAD/CTCF signaling pathway SMAD2 CTCF SMAD4 PMC2949647__F1 Structure and signaling machinery of the Met receptor GRB2 RAC1 CRK CDC42 PMC10912471__F2 Notch signaling pathway in tumor immune microenvironment PMC10912471__F1 Notch signaling pathway FHL1 RBPJ JAG2 PMC4824345__F7 The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136 PMC3785008__F1 Role of hypoxia and HIF2A in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features HEY2 NGF DLL4 VEGFA HEL-S-44 MTOR HES1 PMC8659360__F1 Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility EGF SMAD2 WNT1 SMAD4 PMC5435970__F7 Model depicting the mechanisms by which TIEG1 modulates canonical Wnt pathway activity in osteoblasts LEF1 APC GSK3B LRP5 LRP6 PMC9161817__F1 Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma ATF4 DKFZp686F0183 PMC4346003__F5 Gene network, created using IPA® software, reflecting EGCG treatment.Notes: The overexpressed genes are labeled in red, while those downregulated are marked in green.Abbreviations: EGCG, epigallocatechin-3-gallate; IPA, Ingenuity®Pathway Analysis AIP MYC PMC2939633__F1 Chk1 suppressed death pathways ATM ATR CDC45 BAX PMC8323007__F3 MicroRNA-490-3p and −490-5p in carcinogenesis: Separate or the same goal? TGIF2 SMAD2 TGFBR1 EGFR GSK3B LRP5 VEGFA SMAD4 LRP6 ARHA MTOR TNKS2 TSC2 TSC1 PIK3CA CCND1 FRAT1 SP1 STAT3 PMC3614012__F2 IGF-1R and EGFR/HER2crosstalk occurs by two main mechanisms IGF1R IGF1 IGF2 EGFR PMC7792208__F1 Multistep model of the evolution of classic ILC and its morphological variants ERBB2 ERBB3 PIK3CA PTEN ARID1A PMC5751361__F12 TGFB signaling pathway SMAD2 GRB2 SMAD4 PMC4946436__F8 Interplay between ErbB3 and CXCR4 for the activation of Rac1 and breast cancer cell motility HRG ERBB2 ERBB3 CXCR4 RAC1 PMC4134798__F1 Mechanism of bone resorption in bone marrow metastasis IGF1 VCAM1 CXCR4 LPA CXCL12 PMC4669118__F9 Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway IQGAP1 CDC42 PMC4880855__F1 The (simplified) gene regulatory network controlling primary sex determination in placental mammals (see Additional file : Figure S1 for the more complete network) WNT4 DMRT1 GATA4 SOX9 FGF9 SRY PMC9613846__F3 Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.) ELF2 ELF1 BAK1 SUI1 DLD HEL-S-32 MPG HEL-S-162eP MAX ACSF3 BIN2 EBF2 ELF4 SDHA CYCS PMC8503804__F2 Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway HMGB3 FGFR1 FAM83A EGFR VEGFA RAF1 MYD88 TCF2 PMC3322137__F3 Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests Focal Adhesion and Immunosuppression along with Epithelial-Mesenchymal Transition VASP BAD ARHA PTEN CRK PMC1464269__F1 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies CIT TG MAL PMC3113646__F6 TGFBeta-and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR) PI3 TIMP3 EIF4E MTOR PMC2944409__F7 Gene interaction sub-network of shortest connections to common targets for the 36 candidate regulatory genes obtained by global literature analysis (Pathway Studio 7.0, Ariadne Genomics Inc., Rockville MD) ACTG2 PTGS2 MMP9 EGFR VEGFA CCL5 TNF THY1 NEDD4 MMP14 TIMP1 MMP2 PRP4K VCAM1 PRMT2 GJA1 CXCR4 PRLR CCND1 BCL2 TIA1 THOC2 PMC2944409__F6 Calcium Signaling Pathway (KEGG, Kanehisa Laboratory in Kyoto University, Japan) with vinclozolin altered genes indicated PLN BCR MCU PMC3712669__F1 The estrogen metabolic pathway is depicted CYP3A4 DIO1 PMC3708595__F4 Mutational Landscape of Adenoid Cystic Carcinoma ARID4B MYB MORF4L1 MAML3 MYCBP MYC FGFR4 PTEN FBXW7 JMJD1C SMC1A ATM FOXP2 MAGI1 PRKDC SRCAP NFIB TLK1 DTX4 MAP2K2 UHRF1 HRAS BRCA1 SMARCE1 ARID1A BCOR MYBL1 CREBBP KANSL1 EP300 MAX INSRR BCORL1 KAT6A SETD2 MGA KDM6B PMC5667900__F4 Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway GPX4 LPCAT3 FACL4 SLC7A11 HFE SLC3A2 PMC4642978__F2 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response FGA AQP5 RBP4 SAA2 PTX3 CP SMAD9 PMC7685705__F9 The role of TRAF3 in density-dependent proliferation TRAF3 RELB TRAF2 PMC11650353__F7 Proposed model of curcumin inhibiting PCa progression via regulation of m6A-modified circ0030568-FMR1 pathway YTHDF2 METTL3 FMR1 PMC7411855__F3 MAPK and NFKB signaling pathway of ginkgolides in the regulation of IIR TBK1 TLR4 IRF7 IRAK1 IRAK4 MYD88 TLR1 PMC3334999__F5 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation SOX2 TGFBR1 APC GSK3B TGFBR2 CD44 DKK2 FZD1 NLK APPL2 SOX11 SOX12 JUN TCF4 PMC9448717__F1 Anti-factor H antibody and its role in atypical hemolytic uremic syndrome HEL-S-62p C9 FH C7 C6 PMC3334999__F6 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation AFP BAD BMPR1A EGFR GHR TGFBR2 PTEN CBL PMC9577795__F4 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis DDX51 RAB40A RPRML KRT19 APOC2 AHNAK AATK NPY STK17A RNF113A TEX19 NTRK2 SCG2 UGT1A3 AQP1 MASP1 FOXF2 LRTM2 GFAP GPS1 FUT4 CYP7B1 CHRNA3 UBTF ASGR1 MAPK13 GALR2 WDR5 MMS19 ZIC3 RRAGD KCNN1 SHROOM2 GLIPR1 CDH19 CCND2 PRSS2 CXADR CPEB3 VWF KCTD17 COL23A1 GPR143 TSPAN15 S100A16 ZNF655 ADA PEX10 LNPEP SLC29A4 DOK3 NPTX2 TRIB3 PENK CD74 RUSC2 TRAPPC6B INPP5D PCK2 SLN FOS SSTR3 ZNF701 ZNF264 FERMT3 MED22 DGKZ ACLY GHITM PPP2R5D NEUROG2 TM4SF13 RAB33A KCNMB4 OLFM1 SFN NLRP2 INS NEUROD2 PODN AQP3 AMH TFG NGFR FOXA3 SGTB RAB32 TOM1L2 MAP6 SCG5 HOXB7 AQP5 TMEM119 BMP7 DYNLT3 NPTX1 GJC2 LPGAT1 FAM89A KRTCAP3 MS4A12 PP1187 EDN2 EVC HMSD ZNF831 FAM83E STK38L PRELID2 TGDS TMEM187 SLC13A2 PMC11042021__F8 KEGG pathway diagram for antigen processing and presentation illustrating the central processes involved in antigen processing and presentation, which are essential for immune system function CANX TAP2 HEL-S-99n B2M IFNG TAPBP PMC9577795__F3 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis SPARC PTN ADAMTS3 BMP2 WNT1 INS LAMB3 MAP2K3 CHST14 SSTR2 MED22 PMP22 RHOU STAT1 MAPK13 IGF1 CHRM1 COL1A2 VWF ACLY OSM JUN PMC11042021__F7 KEGG pathway diagram for graft-vs.-host disease depicting the complex interplay of cellular and molecular interactions involved in the pathogenesis of graft-vs.-host disease (GVHD) APC TNF PMC9600014__F1 Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer’s Disease: Do They have a Common Regulating Pathway? BACE1 APP PMC7601265__F7 Illustration of hypothetical antioxidant mechanism for peptide MS15 against oxidative stress MAF KEAP1 GPX1 HEL-S-44 PMC6195737__F2 IGF signaling in the placenta IGF1 IGF2 BCL2 PMC1782796__F7 Affinity maturation, a turning point between life and death for germinal centre (GC) B cells: a working hypothesis CD40 BIN2 AKNA PMC4268052__F6 Holoprosencephaly: signalling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans BOC NODAL SMAD2 SHH SMO GAST SMAD1 DKFZp781O1323 PMC4633891__F10 MiR-148a promotes starvation-induced autophagic activity in HSCs, at least in part, through suppressing the Hedgehog signaling pathway SMO GAS1 PMC1955177__F3 Cell death in the cardiovascular system IGF1R IGF1 UNK BNIP3 MTOR PMC5895746__F2 Schematic representation summarizing the functional effects of the three regulatory pathways controlled by IL-1B MIA REST IL1RAPL1 MTOR IL1B PMC4642978__F1 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response FGA DEFB4B AQP5 RBP4 VPREB1 SAA2 PMC11574184__F6 KEGG pathway analysis INA TRADD CYLD TNF NOD2 SELE PMC9206341__F8 Near-infrared light reduces Beta-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease IL18 TLR4 SRC PMC1143566__F4 Schematic diagram for the Wnt signaling pathway DAAM1 APC RHO CDC42 PMC4271245__F7 Proposed model linking TBX2 and TBX3 to the TGFB1 signaling pathway TBX2 SMAD2 TBX3 SMAD4 PMC1143566__F2 A schematic diagram for the hedgehog (HH) signaling pathway DHH IHH SUFU SHH SMO PMC6281419__F1 PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy IGF1R IGF1 IGF2 CCND1 TLN1 PHIP IRS1 PMC9083544__F1 Engineering Yarrowia lipolytica to Produce Itaconic Acid From Waste Cooking Oil PEX10 CAD CIT PMC10286596__F2 Resveratrol-modulated mitochondrial biogenesis in neurodegenerative diseases NAMPT SIRT4 FOXO3A TFAM SIRT1 FOXO1 TERT PMC10286596__F1 Mitochondrial biogenesis in neurons NRF1 TFB1M MTIF2 TFB2M MTIF3 POLG POLRMT TFAM SIRT1 PMC9563396__F5 Molecular Mechanism of Ferroptosis in Orthopedic Diseases GPX4 SLC7A11 STAT3 PMC11827847__F10 Hypothesized mechanism by which NRP1 mediates NGF/TrkA pain signaling NGF NRP1 PMC9604036__F2 Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases AHR IL1B IFNG PMC7959192__F9 Simplified pathway for NAD metabolism NAPRT NAMPT SARM1 PMC2700095__F10 Alternative kinetic model incorporating unknown transcription factor (TFx) activation by Eda/Edar signaling EDARADD EDAR EGF RELA EGFR FGF8 SHH TRAF6 TNLG7C TGFA TRAF2 PMC8201398__F2 Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights STAT1 NLRP3 TLR4 MUC2 FOXP3 PMC6826302__F2 Mechanisms mediated through IGF-1/IGF-1R IGF1R IGF1 IRS1 PMC6826302__F3 Mechanisms mediated through vitamin D SPARC EGF NR1i1 IGFBP5 PMC8381213__F1 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense ISG15 STAT2 IRF9 IRF3 TYK2 PMC8539140__F3 LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma BIRC5 CCND1 LATS1 TUG1 EZH2 PMC8281578__F1 Neutrophil extracellular traps in cancer: not only catching microbes TLR4 MPO PMC8381213__F2 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense STAT2 IRF9 NUP98 IRF3 FADD MAVS PMC6859340__F7 Mechanism of Cdc42/Wnt/Beta-catenin signaling pathway in ADSC-derived IPCs PDX1 WNT3A APC TCF7L2 NEUROD1 CDC42 PMC11688120__F3 Key signaling pathways in the pathogenesis of CCM CD14 TLR4 KLF4 PIK3CA ARHA KLF2 MTOR SMURF1 HEG1 PMC9009237__F5 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications KEAP1 GAA PMC239898__F6 Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer GNRHR FSHR PMC6079386__F14 Gga-miR-302b-5p and gga-miR-302-3p miRNAs NLK E2F7 F2 TRPS1 LATS2 PMC8656040__F1 Ketone bodies: from enemy to friend and guardian angel HMGCL BDH1 PMC9009237__F4 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications NLRP3 TNF IL1B PMC6954292__F1 Androgen metabolism in human prostate HSD3B1 HSD17B2 AKR1C2 CYP17A1 HSD17B6 PMC11034170__F3 Updated mechanisms of MASLD pathogenesis GPX4 STEAP3 SLC3A2 AMT PMC8761570__F2 Poly (I:C) induces an immune response by macrophages OLR1 HEL-S-30 LIPA GLG1 NOS2 PMC1899986__F8 A model for cyclin E degradation regulated by two E3 ligases CDK2 SKP1 RBX1 CDC34 PMC139433__F2 Cell cycle arrest by transforming growth factor (TGF)B and their deregulation in cancer CDK2 SMAD2 SMAD4 CCND1 CDK4 PMC4606200__F1 Programmed death-1 causes T cell exhaustion STAT1 STAT2 IRF9 ZAP70 TYK2 JAK1 PMC5928215__F1 Protein and cell turnover of the skeletal muscle SMAD2 TNF IL6R IRS1 STAT3 PMC9541052__F1 Severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians PLG PF4 VWF F11 CD40LG TF PMC3409633__F1 TLR signaling controls transcription and mRNA half-life TLR4 IRAK1 IRAK4 PMC2725945__F1 Stabilization, degradation, and activation of the Ci/Gli proteins by the Hh signaling pathway SUFU SMO SPOP PMC2666548__F1 Reactions and proteins of the mitochondrial FAS pathway RPP14 PPT2 AASDHPPT MECR MCAT OXSM HTD2 HEL-S-5 PMC9009237__F6 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications APC GSK3B LRP5 LRP6 DRD2 PMC4768070__F2 BST‐2 in viral infection: BST‐2 tethers viruses to the cell membrane and to each other (1) and (2) PDC BST2 MAP3K7IP1 PMC8269449__F1 Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs LTA COX1 APC PMC6447179__F7 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling HEL-S-62p C4BPB C3AR1 C5AR1 C1QB C1QA CFD C8G C6 SERPING1 C4BPA C1S C1QC CR1L PMC6447179__F9 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling ANGPT2 MGP EGR1 FOS SIGIRR ATF3 FABP5 CXCL2 JUNB CXCL12 HMOX1 CCL3 PMC7042402__F4 Metabolic mechanisms of macrophage polarization NLRP3 ACLY PMC8348138__F5 Transcriptome-Based WGCNA Analysis Reveals Regulated Metabolite Fluxes between Floral Color and Scent in Narcissus tazetta Flower HEL-S-62p POR IPP PMC3541196__F3 Dysregulation of the cell cycle pathway during tumor progression CDKN2D CDKN2C CDKN1B CCNH RB1 CDKN2A CCND3 TFDP1 CDK7 CDK6 CCND2 CCNE1 CDKN1A CDKN2B CDK2 CCNB1 CCND1 CDK4 RBL1 PMC2997006__F1 Tor pathway in the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe TSC2 TSC1 RHEB PMC9545774__F1 Hypoxia in the tumor microenvironment and targeted therapy MICA ADAM10 BNIP3 MTOR PMC6703710__F10 Simplified model illustrating PDGFRA functions in elastogenesis EGF BTC TGFA PMC6767864__F2 IFN-λ4 Conundrum: When a Good Interferon Goes Bad ISG15 IFNA4 TYK2 IFNAR2 JAK1 IFNLR1 USP18 PMC5805379__F3 Renaissance of complement therapeutics CR2 C4A CR1 CP PMC6491460__F2 Modes of MUC1 control of cellular inflammatory signaling pathways MUC1 NLRP3 TLR7 TLR4 MYD88 TLR3 MAVS PMC4859429__F2 Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression AKR1C1 SRD5A2 HSD17B2 UGT2B17 HSD17B3 AKR1C2 CYP17A1 HSD17B10 STAR UGT2B15 HSD17B6 PMC4683091__F2 Position-dependent regulation of cell fate in the preimplantation embryo: known and hypothetical mechanisms RBPJ CDX2 AMOT NF2 TEAD4 PMC8027073__F8 TREM2 and CSF1R interaction in microglial survival CSF1R CSF1 PMC3837458__F1 Triacylglycerol synthesis and acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 DGAT2 HEL-S-5 PMC8013721__F1 Summary of radiation-induced oral mucositis pathogenesis MMP3 IL1B PMC5071109__F4 Cell-free Xenopus egg extracts for studying DNA damage response pathways REV1 RAD17 TOPBP1 ATRIP ATR PMC7508719__F4 The KEGG “TGFB Signaling Pathway” showing differentially regulated genes for the Alizarin (+) treatments (TCPS_OS, PCL_NF, PDLLA_NF) FST BMP6 DCN GIG8 CDKN2B THBS2 THBS1 COMP ID1 LTBP1 PMC10819970__F8 Engineering CXCL12 biomimetic decoy-integrated versatile immunosuppressive nanoparticle (VIN) for the management of overactivated brain immune microenvironment CGAS CXCR4 MSC CXCL12 ARG1 PMC3513983__F3 Major signaling pathways regulating RSV-induced NFKB and IRF activation in airway epithelial cells TBK1 TANK IRF3 TLR3 MAVS PMC4609655__F6 MAPK signaling pathway CD14 EGF MOS DAO FLNA TES TRAF6 TNF NLK NF1 MAX GRB2 ECSIT BDNF TRAF2 PMC64856__F9 Network of metabolic pathways leading from Suc (orange, top left) to the volatile phenylpropanoids, phenylpropenes, and terpenoids formed in EMX-1 basil peltate glands (outlined with yellow backgrounds) HP PPY CAD IPP PMC3079294__F5 SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition RAD18 PCNA PMC5561723__F2 To identify coherent networks of genes influenced directly by smoking, we examined the potential interconnections of the 310 genes identified in the genome wide methylation analysis using PPI information in the STRING database TBCD RALA RPTOR RARA SAFB NR1B3 ITPK1 LPP ETS2 ME3 SKI HNRNPF GATA3 TRIO HEL-S-281 ENO3 NFE2L2 CD44 HEL-S-47e RCC2 CBX4 GNG12 NEDD9 TSHR ZNF217 BRCA2 HEL-S-308 ZAP70 PTGDR2 SMG6 PER3 ADCY9 EXOC2 PMC6073700__F5 GHR-JAK2-STAT pathway inhibition mediated by PTP-1B, SHP-1, SHP2 and SIRPA1 GRB2 SOCS1 STAT3 PMC4547762__F4 Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes FHL1 NAMPT KDM5B MPO POSTN MMP9 LCN2 HEL110 TRIM25 PSMB6 C9 PSIP1 IARS2 CORO1B ELANE MAVS PMC5796892__F11 Schematic representations demonstrating the role LdISP2 in the modulation of host response MASP1 MASP2 C1S PMC6073700__F2 The SOCS proteins mechanisms of GHR-JAK2-STAT pathway inhibition SOCS2 SOCS3 SOCS1 STAT3 PMC6073700__F1 Activation of the growth hormone receptor and its signal transduction ECD STAT3 PMC8287682__F9 CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity CMTM7 POR MTOR PMC2635020__F1 CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC PROTEASE NFKB2 BAX PMC4322534__F3 Signalling networks in mouse and human iPS cells SOX2 LIF GRB2 KLF4 MTOR STAT3 PMC6405828__F2 TYRO3 signaling pathway CCND1 TYRO3 PMC4820821__F1 Hh signaling pathway BOC KIF7 SUFU EVC2 PTCH1 EVC SMO GAS1 PMC7392229__F6 Effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms PLK1 SMAD2 SMAD4 STAG1 DBF4 ORC3 CDK7 CDK6 ORC2 CDC20 CDK2 MDM2 CDK4 PCNA SKP2 MYT1 PMC3729906__F1 Molecules examined by immunohistochemistry PLCG1 IMP3 CCND3 GATA1 ITK NFATC2 FYN HEL-S-171mP LCK UNK SYK JUNB ICOS MAL PMC7874053__F4 Ingenuity Pathway Analysis (IPA) results for candidate genes of LGS or LGS-like epilepsy H2BW2 ANGPTL2 SYN2 RGS4 NRG2 SHANK3 CHD2 UHRF2 CALCRL LRAT PELO VAV3 SNTB2 TBC1D8 NPS ADRA2B SCN10A PMC8480016__F8 Identification of miRNAs-mediated seed and stone-hardening regulatory networks and their signal pathway of GA-induced seedless berries in grapevine (V. vinifera L.) AIP POLE GID8 ARF4 TF HEL-S-5 PMC12013426__F2 Mechanisms of gut microbiome delaying cancer progression TNFRSF1B NR1i1 NOD1 HOPX MMP9 CCL5 MTOR PMC12013426__F1 Mechanisms of gut microbiome inhibiting the initiation of cancers TLR5 CXCL16 TLR4 SP1 IL12A BAX DFNA5 PMC7754005__F3 Down‐regulated differentially expressed genes participated in PI3K‐Akt signalling pathway. Red: differentially expressed genes down‐regulated; green: PI3K‐Akt signalling pathway gene TSC2 BAD MEI1 BCR MDM2 PTEN RAC1 EIF4E MTOR RBL2 RHEB RXRA PMC7663135__F3 Endo-lysosomal system is a complex pathway that is vital to countless processes in the cell, and its dysfunction results in the hallmarks of many diseases ATG16L1 TFEB HEL-S-11 EEA1 ROS1 PMC7754005__F2 Up‐regulated differentially expressed genes participated in PPAR signalling pathway. Red: up‐regulated differentially expressed genes; green: ppar signalling pathway genes UBC PLTP UCP1 AQP7 HEL-S-28 LPL CPT2 PMC11854358__F11 Hypothesized mechanistic diagrams for the effect of PFESA-BP2 exposure on EGF signaling and JAK/STAT signaling based on previous supportive studies SOCS2 EGF EGR1 NFKB1 PTPN1 EGFR GRB2 MTOR JUN SHC1 CEBPB PMC3972679__F2 Apoptotic pathways induced in beta cells in type 2 diabetes NLRP3 BAD IL16 IAPP BAX PMC3972679__F1 The two pathways of apoptosis FADD BAX PMC10616926__F1 Schematic drawing of the major neuroprotective signaling pathways regulated by ghrelin and GHS BCL2 BAX CD36 PMC8257727__F1 Signal transduction cascades mediating cisplatin-induced apoptosis (for details see in the text) MEI1 TBP ATM CDK2 ATF4 MDM2 ATF3 ATR BAX PMC8257727__F3 Signal transduction cascades mediating taxane-induced cell death DKFZp686F0183 PCNA BAX PMC2893101__F3 Apoptosis Signalling network TRADD BCL2 FADD BAX PMC3534691__F8 Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway ERBB2 ERBB3 SRC PMC5381904__F2 Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability PRKAA2 APC CDK4 PDK4 AURKA CDK6 AURKB PMC8187289__F1 CRISPR-Cas9 delivery TLR8 TLR7 TLR9 AIM2 PMC5428490__F2 Transcriptome pattern differs between two oil biosynthesis tissues in oil palm DGAT1 PC GPT2 LPA PPT1 HEL-S-162eP PMC7261837__F8 Anti-inflammatory responses of circumdatin D TRAF6 MYD88 STAT3 PMC12188246__F7 Evaluation of the WNT signaling pathway components in an expanded BMP-SOX9-WNT Turing network SULF1 BMP2 SOX9 PMC2312359__F4 Composite list of expressed genes and enriched transcription factors implicates specific regulatory networks NFE2 E2F4 E2F6 ATF2 MYC ATF1 SOX18 HIF1A E2F3 HES1 BATF MAF NR1i1 NFYC ASCL2 REST SP1 KLF16 TCF3 NCL FOS PBX2 GRB7 RXRA HEY2 MAX EGR2 NFKB2 CREM MXI1 TF NR3A2 RFX1 TFDP2 FOSL2 MEF2D RXRB JDP2 E2F2 MSC NR1A2 JUN NFYA MAFG RORC EGR1 RXRG CREBBP ERBB2 NFIL3 JUND KLF9 NPAS2 SP3 PMC5117493__F6 Signaling pathways associated with differentially expressed proteins as identified by Pathway Studio HEL32 DES WAS PMC4726722__F2 Nrf2 in the metabolism of rapidly proliferating cells ME1 HEL-S-26 HEL107 MTHFD2 PMC6829482__F7 The role of MyoF during skeletal muscle development MYOF APC MYOG PMC3400831__F5 PGI2signaling pathways in VSMCs COX2 ARHA SKP2 PMC9019785__F9 Proprietary Medicines Containing Bupleurum chinense DC. (Chaihu) for Depression: Network Meta-Analysis and Network Pharmacology Prediction NF1 NLK MAX TRADD FLNA TRO TNF TRAF2 PMC4788585__F8 The EGF Receptor Ligand Amphiregulin Controls Cell Division via FoxM1 FOXM1 AREG EGFR CCND1 PMC5817861__F2 Cell signaling pathways induced by Src kinases SRC MTOR STAT3 PMC8909308__F5 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection BAD DIABLO CYCS BAX BOK PMC8909308__F4 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection FOS IRF9 CAST F9 GIP IRF-1 PSMB8 STX12 SOCS1 IFNG BAX PMC2856809__F3 Dual MAG receptor model ARHA LINGO1 PMC7563540__F2 Exosome biogenesis and release TSG101 CD9 CD63 CD82 CD44 PMC11049850__F3 Molecular mechanisms of LPS bacterial interaction with dental stem cells TLR4 IL6 MYD88 DMP1 PMC9161355__F1 Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer CD9 CD63 CD82 CD81 PMC10239924__F1 Raptor in lymphocytes differentiation and function TSC2 TSC1 FOXO3A MTOR DEPTOR FOXO1 RHEB MLST8 CAMKK2 PMC7098264__F1 ApoE Isoform Specific Effects in AD VLDLR LDLR ABCA1 APOE PMC9020986__F4 Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies TIMD4 CCR2 CCR7 GATA6 IL2 PMC8299307__F6 Schematic diagram demonstrating the novel signaling pathway involving EGFR–TRPM7 interaction in VSMCs EGF EGFR TRPM7 PMC3238295__F5 Bridged pairs and shared edges between 2ROs in the apoptosis pathway NAIP BAD MEF2B BCL2L1 CASP10 BMF PROKR1 CASP3 BIK CASP9 BCL2 BNIP3L BNIP3 CAD CASP8 FADD HRK BAX PMC8337009__F4 ICN: extracting interconnected communities in gene co-expression networks MAX APP EN1 TRAF2 APMAP ASIC2 PMC2075101__F1 5-HT2A receptor agonists cause activation of GAq/11 proteins which in turn activate the second messenger enzyme PLC FOS JUN STAT3 PMC4382094__F5 Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase EMD GATA4 PMC8299478__F1 Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients COX1 PMC7254656__F2 Main signaling pathways involved in CD19-BBζ T cells and CD19-28ζ T cells PMC3573348__F3 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECe vs E2F4 KIF23 NR5A2 RPL7A KLF10 SMAD4 FOXN3 ITIH4 STAMBP RPL31 PTPN11 KLHL20 PRKCI CAMK2D SNRK CASC3 STRN3 HMGCS1 KHDRBS1 HNF4A NDUFA3 IQGAP1 PPP2R5E U2AF2 SLC25A1 PMC3573348__F5 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in ECb vs USP4 EIF3A SFPQ USP25 UBE2V1 UBC HEL-S-2a RAP2B PABPC1 RPS27A BNIP3L MED1 RPS6 UGT2B4 MYOG HSPA4 GTF2B PTGES3 TAF1 EIF4E RPS16 RPS3A SSR1 RPL5 CSNK2B MME TRAF4 PMC2374452__F5 Molecular pathways of rheumatoid arthritis-related cartilage destruction as reflected by the in vitro model MMP10 CXCL1 CCR2 MMP12 CCR6 THBS2 CXCR4 CXCL3 CXCL2 CR2 COMP SMS PMC6872668__F8 Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGFB from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer SMAD2 PTEN PMC2882531__F1 Retinoids for Treatment of Retinal Diseases LRAT RPE65 RDH12 ABCA4 RDH8 RDH5 RPE PMC6783844__F1 The illustration of human IgG1 structure with N-glycan attached at Asn297 site in the CH2 of the Fc region HEL-S-62p CS GAL PMC7507029__EV5 Graphical summary of LRP6‐YAP signaling pathway OGT LRP6 LATS1 LATS2 PMC8695855__F1 Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production TLR4 CSA2 SIRT1 PMC9335103__F4 Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS ZC3H12D NIPAL1 LIPH CYB561A3 SYCE2 SH2D1B FBXO34 DENND2D FLNB SLC4A4 ADAM19 MPHOSPH8 TIMD4 NR1i1 FAT10 OGDH RAVER2 NIPA1 TCEA3 RRN3 ADRB1 ERBB3 ADRB2 PIGR GLRX SNAPIN CSTA CD27 HLA-DQB2 DMBT1 IGFBP2 KDSR TF SGPP2 FGF4 ENTPD3 PPFIA2 CNGA1 OAZ1 JAG2 HEL-S-7 CLU MMP27 KITLG NEUROD1 CD3G CHI3L1 PCBD1 CD3D IGF2 CD8A VLDLR ENPP2 HEL-S-301 TRAT1 THEMIS ZC3H12A CTSS FACL4 GATA6 TMEM176A PLA2G7 TNFRSF9 LILRA4 CYLD SND1 SURF1 HSD17B4 RPE PIGL TRAFD1 HSD3B1 CD82 CXCR5 LMNA MED22 DCTN5 TPD52L1 MSMB TOX NCF1 DACT1 GP1BA CASP5 SUPT5H PLEKHG3 TAAR8 SLC39A8 CSF2RB TLR8 RNASEL SYCP3 RNASE1 ARHGAP1 BIRC3 CD2 ATP6V1A DIPLA1 TMEM176B SLCO4C1 UBE2D1 ZBTB1 TAPBP TMLHE ADM2 NFKB1 SIGLEC10 FMN1 SLC1A3 PMC12249970__F5 Activation of AhR by kynurenine, leading to the differential modulation of T cell subsets KY AHR CYP1A1 IFNG PMC12249970__F4 The AhR in modulating adaptive immune responses AIP AHR STAT3 FOXP3 PMC12249970__F7 AhR and JAK/STAT pathway crosstalk in immune regulation COX2 SOCS3 AHR CCR6 TYK2 JAK1 IL4 MAP3K7IP1 IRAK3 IFNG STAT3 PMC2885902__F2 Mitochondrial biochemical pathways that are involved in KATP-independent GSIS ME1 PC CIC PMC4311405__F5 Deregulation of signaling pathways and transcription factors IGF1R KEAP1 EGFR TP63 NFE2L2 TRAF3 MYC FGFR3 AJUBA PTEN RB1 CDKN2A FAT1 HLA-B CDK6 HLA-A BIRC2 FGFR1 ERBB2 CCND1 B2M CASP8 FADD LTBR PMC3104248__F3 Signaling molecules implicated in epilepsy (see the text for the detail) BAD IRS1 FOXO1 RHEB TSC2 PIM1 TSC1 CDK2 MDM2 CCND1 PKD1 CDC2 EIF4B PMC3104248__F2 Genetic mutations of signaling molecules implicated in mTOR pathway (red Xs) STRADA RHEB PMC3104248__F1 MTOR signaling pathway TSC2 TSC1 GSK3B IRS1 RHEB PMC8132044__F1 What does elevated TARC/CCL17 expression tell us about eosinophilic disorders? STAT1 CCL17 IFNGR2 RAF1 IFNGR1 IRF4 SOCS1 PMC3274456__F3 Lipopolysaccharide (LPS)-dependent and nuclear factor (NF)KB-mediated activation of proinflammatory cytokines CD14 TLR4 LBP TRAF6 MYD88 PMC4588138__F1 Schematic of opportunities for host-directed therapies modulating eicosanoid balance COX1 TNF PMC4252069__F6 Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle RICTOR EIF4EBP2 IGF1 EIF3A AAG1 EIF4E MTOR EIF2S2 FOXO1 RPTOR EIF5 PMC4160334__F1 Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells NR3A2 CDKN1B CCND1 SRC BCL2 HBEGF DMRT1 BAX PMC8241768__F1 Molecular Genetics of Marfan Syndrome SMAD2 SMAD4 SKI PMC3573348__F2 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECb vs SRP54 NFE2 NR5A2 CASR IL22RA1 CTCF POSTN TCF12 JKAMP SLC25A40 ZBTB39 SSR2 STARD10 ISOC1 FGFBP1 SH3BGRL2 RPS27A SCFD1 FGF10 TRIP11 PC4 HSPA4 GTF2B TAF1 TMEM208 GUGU DDB2 ARID5A UTP18 DUSP11 P2RY14 ZCCHC8 HNF4A CYP2C9 CUTC RBM15 PWP1 SIX2 BRD4 SUPT5H PMC9479759__F5 Therapeutic potential of WKYMVm in diseases CD9 IRS1 IL1B STAT3 PMC9479759__F3 Therapeutic potential of WKYMVm in diseases ISG15 TFEB FPR2 CD68 PMC8571357__F7 PER2 mediates CREB-dependent light induction of the clock gene Per1 CRTC1 PER2 PER1 PMC4223419__F1 Cellular pathways of prostaglandin (PG) metabolism PTGIS HPGD PTGS2 PTGES SLCO2A1 AKR1B1 PTGS1 PTGES3 PMC6442998__F6 Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition KIT PDE3A SFPQ LIX1 PMC2735047__F3 Graft-versus-Host Disease TH APC PMC8993567__F4 Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical Prospect CD47 EGR1 CD37 CD63 ARHGEF12 CD160 CD48 MTOR CD74 CD79B SOX17 RHEB TSC2 XAB2 HEL-S-171mP CD27 TXNIP IL1B ROS1 AP3B1 PMC5618564__F2 FAK-deleted keratinocytes demonstrate alterations in key mechanotransduction and collagen signaling pathways TRIM72 PMC4396493__F2 No quiet surrender: molecular guardians in multiple sclerosis brain MAF KEAP1 PMC7464415__F11 TLR3-dependent activation of MyD88 signaling: TLR3 activation triggers endogenous ligands of TLR2 (HMGB1 and Hsp60) via the usage of the MyD88 signaling pathway HMGB1 IL18 TNF PMC10375937__F1 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC4207397__F1 Dicarbonyl stress and RAGE signaling GLO1 VCAM1 PMC7998595__F1 Autophagy pathway in podocyte ULK1 WHAMM ATG16L1 ATG12 FOXO3A SQSTM1 JMY MTOR FOXO1 DKFZp686F0183 TSC2 TFEB BCL2 CAMKK2 PMC7338473__F1 Insulin receptor endocytosis in the pathophysiology of insulin resistance CSH2 CDC20 PMC4295834__F4 Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials CXCR4 VEGFA DCC PMC7325485__F1 The dominant control mechanism by which Nrf2 activity is regulated occurs through its association with the E3 ubiquitin ligase KEAP1 and subsequent ubiquitination and proteasomal degradation GSTM2 MAF PALB2 SQSTM1 GCLC GPX2 PGAM5 HMOX1 PMC8771834__F3 Insight of Autophagy in Spontaneous Miscarriage ATG9B TFEB VEGFA SHH CXCL12 CTBS PMC5349319__F3 Summary of identified microRNAs that target key proteins of autophagic pathway for regulation of autophagy ULK1 ATG12 ATG3 SQSTM1 AMBRA1 ATG101 ULK2 UVRAG ATG10 DKFZp686F0183 PMC4742115__F5 Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development SI CLEC2D SFRP1 TCF21 APOE PMC10216337__F6 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in prostate-cancer progression GADD45A TRIM24 PMC10216337__F2 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in colorectal-cancer progression METTL14 SOX2 METTL3 SPI1 KLF4 IGF2BP2 PMC10216337__F3 Schematic representing the suggested roles of and molecular pathways involving MeCP2 in pancreatic cancer LIN28B SOX2 FURIN LIN28A CDH2 PMC3684135__F1 Transforming growth factor B (TGFB) signaling pathway in hypothermia BAMBI EGF MAPK9 RUNX2 MAPK3 SMAD2 TGFBR1 TGFBR2 ITGB6 SMAD4 BMP4 FKBP1A IFNG FST NOG opn THBS1 SKI TGFBR3 JUN RUNX3 SKIL FOS LIF SMAD6 ENG TNF LTBP1 SMAD9 CREBBP NFKB1 JAK1 SMAD1 TGFB1 DKFZp781O1323 INHBA STAT3 FOXH1 PMC6167486__F1 Proposed roles for CXCR3 and its ligands in melanoma CXCR3 CXCL10 APC CXCL9 CXCL11 PMC5618489__F7 Dynmics of starch biosynthetic pathway during development stages of pericarp and endosperm ENPP1 GPT DAP PMC3228910__F2 Expanded representation of the KEGG pathway "colorectal cancer" BAD APC LPA MSH2 LAT PMC8093597__F2 Immunological and physiopathological approach of COVID-19 in pregnancy APC ACE2 TMPRSS2 SELL PMC7226782__F4 GSK-3/Beta-catenin in sensing of cytosolic DNA by the cyclic GMP–AMP synthase (cGAS)/STING pathway TBK1 CGAS IRF3 PMC4888568__F1 Model of insulin signalling pathway TSC2 PI3 TSC1 GRB2 SRC PTEN IRS1 PMC7707088__F1 Function and therapeutic potential of G protein‐coupled receptors in epididymis ERG CFTR GPR64 PMC5597136__F4 Known and recovered GRN for cell cycle pathway in yeast Saccharomyces cerevisiae CDC20 FAR1 CDC6 CLN3 PMC11806845__F1 Mitochondrial membrane permeabilization results in mtDNA leakage FH SNX9 PGAM5 GSDMD BAX PMC6383445__F2 Roles of PARPs in the immune response after pathogen invasion PARP14 PARP12 PARP1 XRN1 PARP15 PMC5134704__F1 The plasticity of EZH2 in regulating MMP-mediated invasion pathway FOXM1 EZH2 SUZ12 EED PMC3053348__F7 The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation TLR9 MYD88 S100B TLR3 PMC8870198__F1 SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link? SMAD2 SMAD6 SMAD4 ARHA MTOR TF CDC42 PMC4730629__F7 Reactive oxygen species (ROS) pathway in bamboo MYB ERF TF PMC9488800__F4 Multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease LTA PGP LTB IL8RB PMC4599578__F6 Cancer-promoting GSNs in A) D-SWCNT, B) D-MWCNT and C) ASB neoplastic-like transformed SAECs COL18A1 FOS DKFZp781B1423 MYC CD44 ATF3 tal-1 IKBKB CCK SNCG MMP2 ATM SPI1 ENPP2 KIDINS220 CSF2 PPARG INHBA SKP2 PMC11806845__F6 Primary cytoplasmic DNA sensors activated by cytosolic mtDNA TBK1 NLRP3 PINK1 CGAS TLR9 RIPK3 IRF3 MYD88 AIM2 ZBP1 PMC11806845__F5 Dysfunction in mitophagy is closely related to mtDNA leakage VPS35 PINK1 FUNDC1 TNF XBP1 TFAM VMP1 BAX PMC8351231__F2 The Hippo signalling pathway NF2 AREG VGLL4 MYC SRC CDCP1 AXL PMC8351231__F1 Different signaling pathways involved in resistance to EGFR tyrosine kinase inhibitors (TKIs) driven by Protein Kinase C delta (PKCD) and receptor tyrosine kinase recycling FER EGFR COPA CDCP1 PMC7105880__F1 Outline of the pathway of eicosanoid synthesis from arachidonic acid COX2 LTA COX1 PMC7793832__F2 NLRP3 inflammasome activation following non-canonical inflammasome activation NLRP3 IL1B GSDMD PMC6851264__F8 Working model of the pathway to maturation of invadopodia when cancer cells are stimulated by transient tugging forces PAK1 LIMK1 RAC1 PMC5260963__F4 Protein interaction map F10 LMOD1 FOLH1 TFPI C4B_2 ALG13 VCAN STMN2 TMPRSS6 MYL10 MBL2 MYOM2 ARHGEF11 ISG15 ERBB2 DHFR BCL2 MAGI1 NCF1 GALNT1 PMC4968084__F3 Unlike the 20S proteasome, the subunits of the Immunoproteasome lack functional EpRE binding domains, and so cannot be regulated by Nrf2 STAT1 JAK1 IFNG PMC8148124__F3 Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle ELF2 XBP1 PMC5487386__F2 Signaling pathways in innate recognition of fungal pathogens and differentiation of CD4+ T helper cells IRF7 TRAF6 NCF4 IRAK4 IRF3 IL6 IL12RB1 NLRP3 CARD9 TLR4 BCL10 STAT4 CD40 SYK RAF1 IFNGR1 PMC3148653__F3 Network of TP53-regulated genes CCNA2 EZR TOP2A POLE2 IER3 PRC1 RRM2 KNTC2 GDF15 opn CCNB1 PHLDA3 MSH2 TNFRSF10C PLAUR FOSL1 MAD2L1 PTGS2 MMP9 HBEGF CENPE IL6 CHEK1 UBE2C TMEM97 MCM6 HMMR CDKN1A NCAPG CCNB2 NEK2 HEL164 TNFRSF10B HMGN2 GTSE1 CDT1 ACSL3 PMC3148653__F4 Network of HNF4A-regulated genes HMGB1 CYP1B1 ATF2 PTPN13 FOSL2 MED18 HSPA4L PMS1 C11orf68 VEGFC AQP3 NUF2 ELF3 HNF4A GPX2 IVNS1ABP ACO2 NFE2L3 NR1H3 NR1D1 PAF1 YPEL3 PMC7933770__F2 PPI network of the DEGs, and the expression levels of the hub genes in PDAC tissues and normal tissues MMP14 PDK4 EPHA4 PMC3958334__F3 Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila MYB DROSHA CDK12 HEL-S-310 CDC37 MED31 RAC1 RPS8 SLMAP RPS29 RPS3A MOB4 NUP153 AGO1 MFAP1 SPX LSM4 RNPS1 RPS3 FNTA PMC11359136__F2 HCMV regulates the classical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC7969743__F3 Emerging role of ferroptosis in intestinal disease CDKN1A SLC7A11 DPP4 GLS2 PMC5483997__F1 Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition SMURF2 SMAD6 SMAD4 RHO SMURF1 ID1 SMAD1 DKFZp781O1323 PMC3932947__F7 En2 modulates IGF1’s pleiotropic effects in GNPs, potentially through altered S6 kinase activation IGF1R IGF1 EN2 PMC11359136__F3 HCMV regulates the Notch signaling pathway SOX2 HEY2 ADAM10 STAT3 PMC4420923__F10 Molecular mechanism for SGK1 signaling and cell survival MEI1 GSK3B PMC9031331__F4 Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder PRKCZ EFNA1 ALK EFNB2 BMP7 RRAS ARHA HRAS PAK1 FYN MAFK NRP1 PTPN1 SHH RND1 CXCL12 DCC LAT NTNG1 PMC7290906__F1 Polyplex internalization pathways, driven by mediators, cytoskeleton movements, and GTPase signaling PAK1 ARHA CDC42 PMC8431517__F10 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout PRKCA PLA2G2A PMC1852238__F1 Role of the glutathione pathway and ABC-transporter family in drug elimination and defense from ROS-mediated oxidative stress ABCC1 GPX1 ABCG2 ABCB1 PMC8755543__F7 Mechanism diagram of KDM4A-AS1 regulating the degradation of AR/AR-Vs USP14 MDM2 PMC11468005__F1 PI3K/AKT/ mTOR signaling pathway TSC2 TSC1 PTEN PMC6557399__F1 HMG-CoA reductase pathway RHO PTP4A3 RHEB CDC42 PMC4131144__F5 Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model ME1 ACACA PDK2 PFKFB1 HEL60 HEL-S-32 HEL-S-26 ACAT1 FH ACO2 GPD2 OGDH ACLY HEL-S-133P SDHA HK2 GLUD1 PMC6161371__F3 Cooperation between c-Myc and YAP/TAZ or HSF1 cofactor (a) Phosphorilation of YAP/TAZ by Hippo signaling pathway promotes cytoplasmic localization and ubiquitin-mediated degradation LATS1 HSF1 LATS2 PMC9519344__F4 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes ATG12 ATF4 BNIP3 ATG10 DKFZp686F0183 PMC7533892__F3 Consequences of IDH1/2-related cancer metabolism for redox homeostasis HEL-S-62p ME1 HEL-S-26 ME2 NOX4 NNT HEL-S-32 SIRT3 PMC9519344__F3 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes ATF4 EIF2A PMC7098128__F2 Extracellular DNA in blood products and its potential effects on transfusion TBK1 TLR9 IRF3 IL1B PMC7533892__F5 2HG interference with the mTOR pathway and collagen maturation RICTOR PLOD1 P4HA1 PLOD3 MTOR DEPTOR KDM4A PMC6129574__F5 Metabolic pathway influenced by patulin and Protein interaction network of Kcr proteins RPL9 CLU CAP2 UTP23 NOG RPF1 RPS2 TEF RPF2 PPT1 RPS20 RPL3 NOB1 VPS35 RPL32 FPRL2 NCL RPL37A RPL38 FES RPN2 SKP1 RPL30 HAS1 RPS15 RPN1 tal-1 SEC63 CPA2 HEL-S-68p EMG1 HEL-S-49 RET UBA2 RPL29 RPL28 SRM SLA2 PMC7698938__F5 Mechanisms of therapeutic effects of Cinacalcet on CKD-MBD SOST CRP PTH PMC8537491__F2 Cellular Signalling and Photobiomodulation in Chronic Wound Repair SMURF2 GRB2 EIF4E MTOR SMURF1 ID1 PMC6859487__F1 Basic metabolic pathways used in T cells MPC1 MPC2 MTOR CD36 HEL-S-162eP PMC9519344__F5 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes ATF4 XBP1 TFAM PMC8962202__F3 CIGB-300-Regulated Proteome Reveals Common and Tailored Response Patterns of AML Cells to CK2 Inhibition LIMK1 GNB2 TSPAN14 MAPK14 KGD4 TMEM63A CCND3 MRPL42 MRPS16 LRRK1 MRPL52 ATRIP PIAS1 SMAD1 RBL2 PIH1D1 ANAPC10 PMC8718819__F1 Rho GTPase signaling in rheumatic diseases MMP3 TNC COX2 PAK1 MMP9 PRG4 RHO RAC1 NOS2 ICOS CDC42 STAT3 PMC12179559__F3 Energy metabolism and signalling pathways involved in IMPDH2 MMP2 APC MMP9 GSK3B CCND1 TRAF6 IMPDH2 MTOR FOXO1 PMC6104680__F6 Mechanisms of interaction between IL-6 and TGFB leading to fibrosis in SSc SRC TYK2 IL6 JAK1 IL6R STAT3 PMC10899349__F1 IGF1/IGF1R axis and its downstream signaling pathway IGF1R BRAF IGF1 GSK3B MTOR PMC6686084__F1 An example of cellular nutrient–gene interaction mechanisms SCD GCK PMC10203752__F3 Mechanisms of proanthocyanidins in treatment of HSP TLR4 MYD88 TNF PMC10489316__F10 Targets-pathways network IGF1R NR3A2 EGFR GSK3B CCL5 BCL2L1 HMOX1 FGFR2 ADAM17 CDK6 INSR STAT1 MMP3 RARA ERBB4 FGFR1 KDR NR1i1 MMP2 APAF1 F2 PTPN11 SRC IL2 NOS2 SELE CTSL RAB5A CTSK MMP9 LCN2 PARP1 ARHA RAC1 S100A9 HEL-S-21 HEL-S-130P NR1C1 RHEB HEL-S-22 CASP3 CDK2 HEL-75 JAK3 PPARG HEL-S-72p CDC42 PMC11174683__F3 Mechanistic map of signaling pathways associated with NPs for liver cancer treatment CD44 SHH CCND1 GBP3 AXIN2 ETV5 MTOR PCNA STAT3 BAX PMC11943704__F5 Plasma Proteomics and Metabolomics of Aromatase Inhibitors-Related Musculoskeletal Syndrome in Early Breast Cancer Patients PGR KRT19 TFF1 EGFR SHE BCL2 EBAG9 HEL-S-130P TF KRT14 KRT10 PMC7265486__F1 Stratification and prediction of drug synergy based on target functional similarity BOC EGFR PMC5261008__F6 The multi-targeted STAT3 and TLR9 for aGvHD therapy TLR9 APC STAT3 PMC5914062__F2 Schematic model illustrating the relationship between glucose metabolism and radiation resistance HEL-S-133P STAT3 PMC4671345__F3 LIF protects cardiac myocytes by both genomic and non-genomic means COX2 LIF GSK3B GRB2 ARHA STAT3 PMC11629383__F3 POU5F1P1 and NANOGP8, two processed pseudogenes encoding functional proteins FGF21 AREG H1-2 SHE STAT3 PMC5928437__F9 miR-103/107 promoted ER stress-mediated apoptosis via the Wnt3a/Beta-catenin /ATF6 pathway in preadipocytes WNT3A BCL2 PMC11629383__F2 Truncated yet functional NOTCH2NL genes NOTCH2 MYC IL4 PMC8616319__F3 Immune Components on Stem Cell and Dormancy in Cancer MMP9 CCL5 CCL2 DKK1 CCDC25 PMC12185661__F3 GPER signaling pathways EGFR HBEGF TF PMC8375100__F1 Kynurenine pathway metabolites in cerebrospinal fluid and blood as potential biomarkers in Huntington's disease IDO1 KMO IDO2 PMC5541669__F3 Recurrent architecture of tumour initiation, progression and drug sensitivity IRAK1 TRAF6 IRAK4 MYD88 MTOR CD79B CD79A STAT1 BTK CARD11 BCL10 BCR SYK TYK2 JAK1 IRF4 STAT3 PMC5919715__F8 PPI and miRNA-gene regulatory networks PLCB3 WNT3A PPP3R2 CCND1 SFRP1 FZD4 VANGL1 FRAT2 FZD5 WNT7B CCND2 PRICKLE2 PMC9284696__F2 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration CD99 B4GALNT2 PORCN NUP62 LCOR SERPINA3 RPS29 PMP22 PRELP FAU CELF6 QRICH1 ZNF84 GRIPAP1 SLC36A3 ERLIN1 SLC26A1 JUNB MROH1 SLF2 MANBAL NPIPB6 ETFA RBM38 SNUPN HTRA1 FADS2 HEL113 COXFA4L2 KLF10 CEBPB DAG1 HBA2 GREM1 BRI3 DCAF13 SYBU COL1A2 PKD1 DEFA3 GNE SUI1 KIAA0319 PEX5 RGCC SIPA1 ANKRD50 NKG7 CAMKK2 PMC9284696__F4 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration FST SOCS3 FOS SMAD2 ACVR1B TGFBR2 MAPK1 KLF2 TGFB1 FOXO1 CCND2 PMC8804296__F1 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis NLRP3 TNF IL1B GSDMD PMC6899955__F1 Screening of Mtb virulence proteins that interact with proteins from macrophages RPIA PSD HEL-S-69p PMC8804296__F3 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis FADD BAX PMC4884045__F1 Mammalian Hippo signaling NF2 TBX5 ARHA LATS1 LATS2 PMC3411424__F4 AlzPathway on Payao system SI COMP PMC3411424__F3 Binary-relation notation and key molecules of AlzPathway TLR4 TIMP1 NGFR APP IL6 MTOR APOE PMC7054734__F9 CircNR3C1-Regulated Pathway in RPE CellsRed arrows indicate promotive function and green lines indicate suppressive function PTEN MTOR RPE PMC7855613__F4 Glycosylation in oncogenic signaling pathways EGF APC GSK3B SMAD4 PMC7682655__F10 Diagram presentation of the molecular mechanism KDM3A PMC10957617__F3 Versatile Mechanisms of STING CGAS SEC24C IRF3 HK2 PMC4918597__F2 MiR-548, miR-27, miR-346, miR-218, miR-34a, miR-21, miR-22 and miR-29b promote the osteogenic differentiation of mesenchymal stem cells through Wnt/catenin, Notch, TNFA, TGFB/BMP signaling pathways NOTCH2 RUNX2 APC GSK3B DUSP2 DKK2 HES1 PMC7688515__F1 Immunometabolic pathway during mycobacterial infection TFEB IL1B NR1C1 PMC5526991__F5 Extended Kegg Pathway for PI3K-Akt signaling BAD PTEN LAMB4 opn COL9A2 MDM2 VWF THBS1 COL9A1 XB LAMC2 RELN LAMB3 LAMB2 THBS4 LAMA3 LAMA1 TNC LAMB1 THBS2 THBS3 VTN IBSP CHAD TNR COL9A3 COMP PMC3781192__F1 Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults MTR SLC19A1 PMC5834792__F3 Drug resistance in anaplastic lymphoma kinase‐rearranged lung cancer HGF EML4 ALK ERBB3 EGFR TGFA PMC12049683__F6 TMAO inducing cell ferroptosis GPX4 STEAP3 SLC7A11 FTL SLC3A2 TF PMC9454744__F3 Small Nucleolar RNAs and Their Comprehensive Biological Functions in Hepatocellular Carcinoma MDM2 FGFR2 PMC4791320__F2 Energy balance signaling, leptin and insulin interaction with possible ciliary genes TSC2 POMC TSC1 AgRP SSTR3 LEPR MTOR RHEB INSR STAT3 PMC12049683__F5 TMAO inducing cell pyroptosis NLRP3 GSDMD ALDH2 BAX SDHB DFNA5 PMC12049683__F4 TMAO inducing autophagic cell death ATG16L1 ATG12 ATF4 MTOR DKFZp686F0183 PMC12049683__F3 TMAO inducing cell Apoptosis NLRP3 ATF4 XBP1 CRYAA STAT3 PMC3180702__F6 Transcriptional complexity of the mesenchymal-epithelial transition network EMX2 EYA1 PAX2 FGF2 FGF8 LHX1 OSR1 PMC10814071__F4 Regulatory Gene Network Associated with the Ameliorative Effect of Oat Antibacterial Peptides on Rat Colitis LPP SKI MTOR PMC5849426__F7 Putative model illustrating the interplay between RANK/NFKB-dependent and Hdac3-dependent control of mTEC development HDAC3 POU2F3 SPIB EHF NFIB TEC PAX1 PMC3641106__F8 Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi TLR9 PMC8703376__F2 Inositol Phosphates and Retroviral Assembly: A Cellular Perspective MINPP1 IPPK ITPK1 IPMK ITPKA PMC6958407__F4 Proposed model for modulations of Hippo pathway by PDEF YAP1 LATS1 LATS2 PMC8833440__F1 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway S1PR2 S1PR1 S1PR3 S1PR5 SPHK1 S1PR4 SPNS2 SPHK2 PMC6345631__F1 Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae TEAD3 TEAD4 LATS1 MOB1A MOBKL1A LATS2 CAVIN1 TEAD2 PMC3865655__F1 Caveolin-1 is a highly versatile regulator of cell signaling CSK CCND1 SRC GRB7 PMC8833440__F2 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway S1PR2 S1PR1 S1PR3 SPHK1 RHO S1PR4 SPHK2 PMC6991676__F7 Hypothetical pathway related to the disease pathogenesis process CDKN1A MYC RB1 PMC7193445__F2 Examples of SLC mediated drug transport across the blood-brain barrier and in glioblastomas and neurons SLC7A5 SLC22A5 STAT3 PMC5067323__F1 Metabolic pathways associated with DA TH DDC DBH ALDH3A2 MAOA PAH ALDH2 PMC3907060__F4 Analyses of differentially expressed genes regulated by fasting in all three tissues revealing an involvement of p53 and Srebp signaling pathway ACACA MVK IDI1 ACSS2 ACAT2 RXRA PMVK MVD LPIN1 FDPS CREM HEL-S-44 ACLY SESN2 PMC4346882__F3 Schematic depiction and overview of PI3K/AKT/PTEN signaling has been shown TSC2 TSC1 PTEN MTOR PMC10253150__F6 Wnt signaling pathway, including the canonical pathway, the pathway associated with cell polarity determination (Wnt/PCP), and an increase in intracellular Ca2+ (Wnt/Ca2+), whose genes were significantly regulated in the ZG zone CTBP2 PPP3CA CSNK2A1 PPP3CC SOST MYC PORCN DKK1 SOX17 PRKCA DVL2 ROR2 ROCK2 SFRP4 CSNK1A1L FOSL1 APC MAP3K7 TCF7L2 DKK4 PLCB1 PLCB4 PLCB2 PRKCB PPP3R1 CSNK2B PLCB3 GPC4 CTBP1 PPP3R2 RYK SENP2 DKK2 NKD2 CXXC4 CCND2 NKD1 CCND1 TCF7L1 FRAT2 JUN INVS DAAM2 NFATC1 NOTUM CER1 CAMK2G ARHA WIF1 DVL3 NFATC3 DVL1 NLK LEF1 NFATC2 CAMK2A PMC10253150__F7 Biogenic amine synthesis signaling pathway, whose genes were characterized by expression significantly regulated in the adrenal medulla GAD2 TH ChAT TPH1 MAOA ACHE PAH GAD1 HDC AANAT ASMT PNMT DDC DBH PMC3753466__F3 Skp2/Cks1 is induced by the TNFA/NFKB signaling pathway in nephropathy TRADD RELB TRAF2 SKP2 PMC4320441__F3 49 genes whose functional domains were changed by DAS exons EGF KIT EP400 ARHGEF12 EGFR HBEGF ARAP1 MTOR CDKN2A RHEB TSC2 TSC1 MDM2 GRB2 KITLG TGFA SHC1 PMC4269730__F5 Transforming growth factor (TGF)-beta signaling pathway BMPR2 SMAD2 SMAD6 TGFBR2 SMAD4 SMAD1 DKFZp781O1323 PMC8138183__F2 Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells STAT1 EGFR SP1 PMC8988234__F3 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance GPX4 PROS1 SLC7A11 TYRO3 SLC3A2 PMC8988234__F2 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance GPX4 LPCAT3 STEAP3 HEL-75 TFRC DHODH IPP TF PMC9489416__F9 MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway CTSK RUNX2 NFATC1 TRAF6 ACP5 MCU ATP6V0D2 PMC2950025__F1 Models of mitotic exit in yeast CIB2 APC NET1 CDC2 PMC4234693__F2 Three Wnt-dependent pathways have been categorized: canonical Wnt/Beta-catenin and non-canonical Wnt/PCP as well as Wnt/Ca2+ pathways APC GSK3B ARHA PMC4234693__F4 Influence of non-canonical Wnt signals on the MAPK pathway MMP3 RUNX2 APC MMP9 GSK3B SOX9 PMC4234693__F3 Influence of canonical Wnt signals on the MAPK pathway WNT3A APC GSK3B ARHA RHOB SOX9 CDC42 PMC4234693__F5 Influence of MAPK signals on the Wnt pathway APC GSK3B SOX9 PMC3193426__F1 DSB repair pathways and SUMO SMC6 RAD18 SMC5 PCNA PMC4511863__F6 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease DOK3 TLR4 MS4A6A MYD88 NOS2 TYROBP STAT3 PMC5045138__F2 During homeostatic conditions, the Keap1 proteins binds with the nuclear factor Nrf2, inhibiting its translocation to the nucleus and the induction of the transcription of Nrf2-dependent reading frames MAF KEAP1 PMC7990372__F2 Illustration of the processes of iron uptake, storage, and efflux in the retinal pigment epithelium (RPE) cells STEAP3 FTMT HFE TF TFR2 PMC4511863__F1 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease LBP TRAF6 LY96 MYD88 MAP3K7IP1 IRF-1 IFNG PMC8441048__F7 Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology HEL-S-44 PMC8292968__F2 Non approved pharmacological targets and interaction of selected profibrotic pathways in SSc myofibroblasts that are currently being evaluated in clinical trials MRTFB IL13RA1 SRC NOX4 TYK2 MC1R RHO LPA JAK1 mkl1 STAT3 PMC7072578__F2 Autoimmune response signatures for ovarian cancer IGF2BP1 KDM5B PLK1 SMYD2 HSPA2 MYC MLF2 NACA SAA1 CD74 TXN ORM1 TMSB4X TMSB10 ANXA2 E4F1 SERPING1 ACTBL2 UVRAG CEP170 RBM38 KIF24 CALU CTSO PTBP1 ENO1 PIGR BRCA1 EIF4G1 HEL-S-22 HEL-S-49 TMEM97 RFFL ZNF217 TP73 HEL-S-276 HEL-75 HEL113 SESN1 RBFOX2 TNFRSF10A SUMO1 MYH9 NFATC4 DKFZp781B1423 HEL-S-116 PTEN RPTOR BAG1 LGALS3BP POU2F1 STC2 ARF4 PKD1 PHF20 MDK SH3RF2 YPEL3 CEP55 RNF38 CENPK HEL-S-102 FUBP1 NOP56 DNAJA2 SERINC3 PMC4783934__F4 Six miRNAs and their target genes that are involved in milk fat metabolism in bovine mammary gland PTGIS PTGS2 HADHB ALOX15 PDPN ELOVL6 CD74 PTGS1 EDN1 HPGD QK3 LPL SYK PRKAG3 UCP3 PMC6694157__F5 P53 signaling pathway (hsa04115) is extended in the weighted network AIG1 POLR3GL MADD SETMAR FAIM PFKFB4 ORM1 CRYAA PTS CCNI SIAH1 MDM2 MZF1 ZNF174 TMEM79 AGBL2 RHOBTB3 CD82 HLA-DOB TP63 TLK1 RBX1 UHRF2 RHOBTB2 CINP PPM1D RAB36 TP73 BCL2 ATR ANKRD12 HLA-DMB HYI SFN PTEN EI24 PPBP IGFALS SLC12A8 IRF6 BNC1 GADD45B AGTPBP1 ATM KNG1 FUNDC2 BAX SLC25A24 MIDN RPRM DEDD CD160 DEHAL1 RNF38 KLKB1 ST14 CTSG USP40 AK3 INHA SIPA1 TBCC CYCS PMC6590237__F1 Dorsal root ganglion (DRG) neurons branch out to the skin with transient receptor potential channel vanilloid 1 (TRPV1)/transient receptor potential channel ankyrin transmembrane protein 1 (TRPA1) and other receptors expressing NGF TRPA1 TRPV1 PMC4013405__F3 nAChR-mediated signaling in lung squamous cell carcinomas and adenocarcinomas EGF EGFR SRC PMC7445810__F4 Interactions between the hypoxia inducible factor (HIF) and circadian pathways CRY1 PER2 PMC4790729__F2 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders BAD IGF1 GRB2 PMC4790729__F1 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders GRB2 PTEN RAF1 EIF4E SOS1 MTOR IRS1 PMC2991085__F2 Stress-Activated Cap’n’collar Transcription Factors in Aging and Human Disease MAF KEAP1 BACH1 PMC2774738__F3 Specification of cell fate in the mammalian cochlea SOX2 JAG2 FGF8 FGFR3 LFNG ID1 ID3 FGF20 BMP4 HES1 HES5 FGFR1 EYA1 GIG8 HEY2 ATOH1 GLI3 SHH PMC4179613__F3 MicroRNAs expression profile in CCR6+ regulatory T cells FYN EPO BCL10 LCK CDK4 LAT CBL PMC11914797__F5 BBR and its derivatives are involved in autophagy mechanisms PINK1 CGAS ULK1 TFEB CD44 MTOR DEPTOR ATG14 MLST8 PMC2965188__F2 Nrf2 cytoprotective signaling pathway MAF KEAP1 RBX1 PMC7833428__F6 Functional significance of activation of EGFR, IGF-1R, and B1-integrin receptor downstream signaling in wound healing IGF1R EGFR GRB2 SHE SRC PMC11914797__F2 BBR and its derivatives influence the mechanism of apoptosis BAX PMC5996891__F5 Homology modeling of Staphylococcus aureus phenol-soluble modulins (PSMs) PSMA4 PSMB2 PSMA2 PMC7833428__F4 Extracellular PEPD induced expression of the B1-integrin receptor and IGF-1R signaling proteins in control and “scratched” fibroblast models IGF1R GRB2 SHE HEL-S-162eP PMC8589992__F6 Proposed working model of FATP5-mediated effects on HCC cells CDH2 MTOR PMC3224200__F1 Contribution of chemoattractant GPCRs to glioma stem-like cell mediated tumorigenesis, invasion and angiogenesis express various GPCRs CXCR4 EGFR STAT3 PMC6335974__F1 Network displaying key genes involved in apoptosis, DSB repair, Fanconi anemia pathway and homologous recombination CASP3 FANCD2 ATM BRCA2 CASP9 BCL2 ERCC5 RAD51 FANCL ATR TP53BP1 TERT PMC3334602__F10 Putative signal transduction pathways regulating fruiting body development in C RHO CDK7 CDC42 PMC3774995__F2 Schematic representation of p30 functions TLR4 ATM CDK2 MYC PMC2792912__F6 Model of Six2 function during mouse pyloric sphincter development BMPR1A SI SIX2 SOX9 BMP4 PMC6989403__F8 PMEPA1a promotion of tumor progression is mediated by Hippo signaling LATS1 TMEPAI NEDD4 PMC6161810__F1 Wound healing, cellular regeneration and plasticity: the elegans way MCU CDC42 CST1 PMC8638406__F8 IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases CXCL1 CXCL5 IL8RB IL17RC PMC3221598__F3 Protease Regulation: The Yin and Yang of neural development and disease APP SRC DCC PMC8063444__F5 5-HT, produced by TPH2, regulates the serotonergic synapse pathway (a) and oxytocin signalling pathway (b) in the hypothalamus EGF GNG13 CAMK4 EGFR TPH2 OXT GABRB2 PTGS1 PMC6918647__F3 Network analysis using Ingenuity Pathway Analysis (IPA) among 4 upregulated (a: HMGB1, HOXA13, SREBF2, MECOM) and 3 downregulated (b: NCOA2, CSHL1, HDAC5) transcription factors and differentially expressed genes due to onset of ketosis postpartum SKIL TSC22D3 BMP2 EBP ADFP NAPB BMP7 PTEN FOXA2 FST DBI DCN ITGB4 TMEM97 HEL-S-78p AHR SREBF2 GHRHR TRIM24 ACR PMC6446698__F1 PI3K signaling pathway: growth factors such as insulin stimulate tyrosine kinase receptors resulting in their autophosphorylation BAD TSC1 MDM2 TXNIP PTEN IRS1 RHEB INSR PMC6842518__F5 Proposed model depicting the underlying molecular mechanism by which aqueous bark extract of T XBP1 CD36 PMC2856775__F1A Convergence of Pathways in TLR and IL-1R SignalingUpon activation, the IL-1 receptor dimerized with the IL-1 receptor accessory protein TLR7 TLR4 TLR9 IRAK1 TRAF6 IRF3 MYD88 TLR1 TIRAP PMC5355421__F1 Schematic illustration representing the microglial intracellular Ca2+signaling mediated by canonical transient receptor potential 3 (TRPC3) channels and the tripartite synapse TRPC3 BDNF STIM1 IFNG PMC7184480__F2 Schematic diagram of the RAS in the lung showing the role of ACE2 as a key element in the counter-regulatory axis of the RAS (elements in green; reviewed in Arendse et al.) ATR ACE2 ADAM17 TMPRSS2 PMC8910720__F3 Pathogenesis of Cardiac Fibrosis: A Review of Recent Progress TNC SMAD2 SMAD6 SMAD4 TBR1 RHO PMC2957678__F1 Schematic view of HMGB1 signal transduction HMGB1 MYC MDM2 PTEN PMC6323259__F4 Schematic presentation of the proposed effects of melatonin against ANIT-induced intrahepatic cholestasis GCLM KEAP1 GCLC PMC9554150__F4 Immunopathogenesis and environmental triggers in coeliac disease IL2 MICA JAK1 TNFAIP3 IFNG STAT3 PMC3573271__F1 Role of aryl hydrocarbnon receptor (AHR) signalling on CD4+ T cells STAT1 AHR FOXP3 PMC9147806__F3 Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2 TBK1 STAT1 STAT2 IRF9 TRAF3 IRF3 TYK2 JAK1 IFNAR1 TRIM25 MAVS PMC8918193__F7 S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3B and CK1A S100A16 HGF APC GSK3B PMC7895420__F1 Molecular pathways control protein synthesis and degradation in skeletal myocytes IGF1 SMAD2 AMBRA1 SMAD4 MTOR PMC11877274__F1 Mechanism and site of action of pharmacological agents targeting the IL-17 signalling pathway (figure created in BioRender.com). SABR, single-arm pilot study of brodalumab TRAF6 IL17RB IL23R IL17RC PMC9019350__F1 Sea Cucumber Compounds Targeting NFKB in Cancer Treatment VCAM1 CXCR4 MMP9 EGFR CXCL8 CCND1 BCL2 CCND3 LTBR CCND2 PMC4384696__F5 Indoleamine 2,3-dioxygenase pathways of pathgenic inflammation and immune escape in cancer ELF2 MTOR PMC7830279__F1 DSB end resection and repair pathway RAD52 RAD51 PMC8572460__F1 Ferroptosis in lung cancer HEL-S-89n GPX4 LPCAT3 FACL4 SLC7A11 GCLC NFE2L2 LCN2 ATF3 USP35 TFRC HEL110 POR HEL60 AIFM2 ATF4 HEL-S-64p ADA HEL-75 IREB2 SLC3A2 SLC40A1 DHODH TF PMC8010074__F9 Craniofacial Development: Neural Crest in Molecular Embryology SOX2 RUNX2 SOST CD44 DLX5 COL1A1 SOX9 ALPL SOX5 COL2A1 SOX6 COL10A1 ALPI PMC2841319__F1 Pathogenesis of kidney disease in systemic lupus erythematosus EGR1 PLG CD44 SMAD4 PMC6356271__F2 Terminal telomeric complex CTC1 STN1 TEN1 ATM NHP2 GAR1 TPP1 ATR GCG NOP10 TERT PMC7688515__F2 AMPK-mTOR axis in the co-regulation of autophagy and immunometabolism ULK1 LGALS9 USP9X MTOR ESRRA IL1B PMC5356795__F6 Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network CDK2 CA14 RAD21 PCNA MAL PMC3721632__F1 Th17 cell based vaccines in mucosal immunity CXCL13 CXCL1 BCR CXCL10 IL22 CXCL9 PIGR IL23R IL1B CXCL11 IFNG PMC3726942__F10 Roles of the autocrine angiotensin system in ER stress-induced apoptosis of alveolar epithelial cells ATR ACE2 PMC4070007__F1 Simplified diagram of the TLR-mediated and interferon (IFN)-mediated immunity in response to viruses IRF7 TRAF3 IRF3 IRAK4 TLR3 TERT PMC4077897__F1 Emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections PI3 SQSTM1 AMBRA1 ATG14 CFTR PIK3R4 PMC3208628__F5 Integrated Transcriptome and Binding Sites Analysis Implicates E2F in the Regulation of Self-Renewal in Human Pluripotent Stem Cells PRKCZ NRF1 HEL2 FGFR4 FGFR2 PCDH19 CELSR2 FRZB GNG4 FGFR1 MAPK1 PCDH10 HELLS SOX2 MAPK7 APC MAP3K7 LRP6 RRAS RAC1 SMARCE1 GNA11 SMARCD2 HEL-S-42 HLTF SMARCD1 PMC7697203__F14 Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications CS PPY PMC3867386__F8 Pre-Symptomatic Activation of Antioxidant Responses and Alterations in Glucose and Pyruvate Metabolism in Niemann-Pick Type C1-Deficient Murine Brain ME1 ME2 PDK2 ENO1 ENO2 PFKM PFKP HEL-S-133P PMC9455248__F5 Lipidomics and Transcriptome Reveal the Effects of Feeding Systems on Fatty Acids in Yak’s Meat ME1 SCD SLC27A2 FASN PMC6553502__F2 Parallel Molecular Evolution in Pathways, Genes, and Sites in High-Elevation Hummingbirds Revealed by Comparative Transcriptomics ETFB UQCRB NDUFB4 COX1 ND1 NDUFB10 ATP6V1D NDUFS8 HEL-S-32 SDHA UQCRQ PMC5668198__F1 Neural Stem Cell-based Regenerative Approaches for the Treatment of Multiple Sclerosis PC HGF TLR9 IGF1 CX3CR1 PMC9454092__F6 Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease CS SMAD2 SMAD4 MSTN PMC9637027__F2 A3A (A) and A3B (B) expression by HPV E2F4 E2F6 UBE2L3 STAT2 RBX1 ZNF384 PMC6859461__F3 Cancer pathway analysis of DEPs FER BAD MADD PMC4934079__F6 Model for how autophagy regulates Notch1 signaling pathway in biliary differentiation of hepatic progenitor cells NOTCH1 MTOR STAT3 PMC7783467__F3 FGF19 and FGF21 treatment of NASH FGF21 FGF19 FGFR4 TG TGFBI CYP7A1 PMC10706690__F6 CPNE7 study schema related to EMT MMP3 MMP2 CDH2 COL1A1 CPNE7 PMC9263642__F5 UVB irradiation differential regulate miRNAs expression in skin photoaging CD14 TRADD FLNA PROC TNF NLK BTK MAX HP APP ECSIT RAF1 TRAF2 MEF2C JUN APMAP PMC9021242__F6 Hippo signaling pathway in asthma NOTCH4 S1PR2 APC IL33 CCL20 IL25 TNF TSLP PMC3469232__F1 Cholesterol is converted to pregnenolone by cytochrome P450scc inside steroidogenic mitochondria SRC PGRMC1 PBR PMC9021242__F2 Hippo signaling pathway in ALI S1PR2 MMP2 FGF10 WNT7B PMC5345234__F5 MAP2K5-centered gene clusters exclusively based on pathway and physical interactions FLI1 CDON IGF1R NUP62CL SETDB1 KIF3A NOX4 ENG CHRNA1 POR IL15 TSC2 RET MDM2 TBXA2R JAK3 IL-21 SPOP CSF2 IL18RAP PMC9021242__F1 Hippo signaling pathway VGLL4 MYC LATS1 LATS2 PMC5345234__F4 CXCL5-centered gene network upregulated in astrocytes in response to Meth exposure PSG1 PAX2 CXCL5 HSD11B1 SAMSN1 OR2B2 AGTR2 UPK1A GNB3 XCL1 SCN7A TACR3 FCGR2B CCL27 CXCL11 GPR45 PLG ZNF208 CXCL10 IL1RN PLA2R1 CEACAM8 CPB1 POU4F1 CCL15 ATP2B2 TBXA2R IL18RAP PMC1579207__F3 Cadmium-induced regulation of SCFMet30 CD2 SKP1 CDC34 PMC9023560__F7 HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis HGF NGF CDH2 MTOR PMC5345234__F3 Connectivity of genes that were upregulated in astrocytes by Meth EPOR MSR1 HSD11B1 CENPF OR2B2 PTGER3 PAX3 IFNG ACSL6 RAP2B NAV3 XCL1 SOX30 FCGR2B PHF3 CXCL11 HCFC1 GPR45 ZPBP DLG2 KIAA0040 ERBB3 CXCL10 ZNF256 ADAMTS8 GLRA2 CCIN CPB1 POU4F1 TSHR IL2RG ZNF76 IGF1R PSG1 PPFIBP1 AGTR2 GNB3 KYNU PTPN11 EPS15L1 LAD1 PTGDR MAML1 GNRHR FCN3 TRIM29 PTPN22 RBPMS CPB2 SMG1 PMC9630901__F12 Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings GFAP TRAF6 MYD88 MTOR CD68 MAL PMC11507121__F6 Transcription and expression analysis of genes related to wax synthesis pathway in leaves of ‘Ningqi I’ goji and ‘Huangguo’ goji CER1 HEL-S-5 PMC6588834__F1 Examples of RRNPP pheromone signaling OMP SI PMC3307000__F3 JNK signaling pathway regulates axonal transport and autophagy APP BCL2 BNIP3 FOXO1 PMC6128059__F1 Representation displaying the two different signaling pathways, RET-dependent (A) and RET-independent (B).In RET-dependent, glial cell line-derived neurotrophic factor (GDNF) binds directly to GDNF family receptor alpha (GFRA)1 RET FYN FOS GDNF PMC3203674__F1 Coronin 2A-dependent LXR transrepression pathway in macrophages TLR4 HDAC3 JUN SENP3 PMC7881844__F2 Loss-of-function (LOF) mutations in components of the insulin signaling pathway found in patients with syndromes characterized by severe insulin resistance PPP1R3A PDK2 TBC1D4 IRS1 FOXO1 INSR PMC7821223__F5 Transcription-related gene network FOSL1 SNAI2 SYK ETV5 PMC4121055__F1 Beyond NPM-ALK driven lymphomagenesis: alternative drivers in Anaplastic Large Cell Lymphoma NODAL ALK TP63 NOTCH1 IRF4 STAT3 PMC7821223__F4 Hsf1-regulated gene network HEL-S-102 DNAJA4 BAG3 HEL-S-101 APP DNAJB1 HSF1 HEL-S-72p PMC12079090__F10 PAX7 in Breast Cancer Prognosis and Its Mechanistic Involvement in the Wnt/B‐Catenin Pathway PAX7 LRP5 CCND1 LRP6 PMC4202272__F1 RANK signaling pathways NFATC1 OSCAR TRAF3 TEC TRAF6 MAP3K7IP1 CBL BTK NFKB2 TRAF5 GAB2 TMEM64 SYK TRAF2 PMC3938254__F7 Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis E2F4 CDKN2B HEL-S-99n ABCA1 PMC9181147__F4 Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review ATG16L1 ATG12 ATG3 ATG14 DKFZp686F0183 RB1CC1 PMC3433920__F4 Acute phase canonical pathway and corresponding acute phase reactants identified as significant for interaction effect FGA HEL-S-62p HRG CFB HEL-S-92n MTOR SERPINA4 SERPINA3 SERPINC1 HEL111 C9 SERPIND1 CRP AHSG LBP SERPING1 APOH CP STAT3 PMC5498655__F1 Metabolic and transport pathway for irinotecan (CPT-11) CES2 CES1 CYP3A4 APC UGT1A1 PMC9024538__F2 Targeting Wnt/Beta-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents DAAM1 ARHA ROR2 JUN CDC42 PMC9224386__F4 Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression BOC CORIN CHUK IL1A MAP2 MALL SOS2 ENG EDAR PIAS2 BIK RELA CTRL EVI1 CAD PMC11719737__F4 Molecular mechanisms of UBE2T in tumorigenesis FANCD2 APC UBE2T FANCL MTOR PMC7897698__F2 Regulatory cascade of MIR211 involving the BRAF/ERK5/DUSP and PDK4 BIRC2 PDK4 PMC8822171__F3 Caffeine Therapy for Apnea of Prematurity: Role of the Circadian CLOCK Gene Polymorphism AIP AHRR AHR SRC MAL PMC7897698__F1 Model summarizing the regulation of MIR211 gene expression: MIR211 gene is nested within the TRMP1 transcript RAB22A BCL2 KCNMA1 TRPM1 PMC3466981__F2 Ubiquitin ligase complexes SCF and APC/C in ubiquitin-mediated proteolysis of regulatory molecules essential for cell cycle control CDK2 APC CDK4 CDK6 PMC3763710__F1 The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise MDM2 PRIMA1 SIRT1 BAX PMC3360162__F4 Synthesis of eicosanoids and their actions in mast cells COX2 LTA COX1 LTB PMC3466981__F3 The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis ATM BRCA2 RAD51 BRCA1 PMC3360162__F2 Antigen-mediated chemotaxis GAB2 BIK LYN GRB2 SYK RHO PTEN LAT STIM1 PMC6255774__F8 A simplified diagram of fatty acid synthesis, modification and assembly into triacylglycerol in developing Arabidopsis seeds PC LPCAT2 LPCAT1 PMC3376408__F1 IL-2 release by DCs stimulation of PRRs triggers the calcineurin/NFAT pathway via PLCG2 and intracellular Ca2+ flux CARD9 TLR4 TRAF6 CD40 SYK PLCG2 MYD88 PMC10136495__F3 Targeting TGFB signaling pathway in LC SOX2 MMP2 MMP9 TGFBR1 MYC VEGFA IL2 IL6 COL4A1 FOXP3 PMC10136495__F2 TGFB signaling pathway in LC development and metastasis SNAI1 SOX2 MMP2 MMP9 TGFBR1 MYC VEGFA IL6 RHO MTOR FOXP3 PMC11853202__F5 Schematic diagram displaying APOL1RRV-mediated downstream signaling pathway leading the activation of the RAS and participating in the progression of CKD NR1i1 WT1 PMC5047620__F6 Role of Dicer1-Dependent Factors in the Paracrine Regulation of Epididymal Gene Expression P1 PHOSPHO1 SHCBP1L DNAJB7 GGN PAPOLB HDAC1 PMC9616754__F1 Amyloid B in the pathological mechanism of GNE myopathy GNE ULK1 IGF1R ATF4 APP PTEN VCP XBP1 BAX PMC5486101__F1 Schematic overview of the autophagic pathway and potential drug target points of the pathway ULK1 ATG16L1 ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 PMC2743144__F1 mTORC1 signaling governs hematopoietic stem cell quiescence PML PTEN FBXW7 RHEB PMC5876722__F1 Oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus TSC2 PLCG1 TSC1 SYK EIF4E EIF4B PMC5303891__F1 Development of a Reporter System for In Vivo Monitoring of Gamma-Secretase Activity in Drosophila EGF HBD PMC10521544__F6 Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma BAD HPD MADD CYC1 COIL CAD MATK MEA1 SELL PMC8419240__F5 Arsenic: Various species with different effects on cytochrome P450 regulation in humans AHR CYP1A1 PMC10521544__F4 Luteolin-target-pathway network MAPK9 PLK1 MAPK8 ALK CSNK2A1 MAPK3 CXCL8 CCL5 BCL2L1 CCL2 MYD88 HIF1A HMOX1 CDK6 IFNG MMP3 KDR MMP2 MDM2 FOSB MAP10 CASP9 SRC CSF2 TP63 CXCL10 MAP3K7 VEGFA TNF CDK2 TP73 BCL2 CXCL12 TGFB1 TBK1 EGF IGF1R CHUK SFN ACTA2 EGFR PTEN PIM1 TLR4 AHR CCND1 VWF CD40LG CDK4 CDC2 IL4 IL1B JUN BAX EGR1 IL13 FGF2 IFNB1 IL5 PKN1 CASP3 BIRC2 CCNB3 NFKBIA COL4A3 SLC2A4 AGER ERBB2 NFKB1 IL3 TNFSF10 RELA CCNB2 CD40 SYK JUND MCL1 VEGFB CCL3 PMC8886744__F2 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease TLR4 IL17A CCL2 TNF APOE PMC8886744__F1 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease NR1C2 PPARG NR1C1 PMC7942223__F2 One-carbon metabolism, transmethylation reactions, folate cycle, and DNA demethylation HEL-S-61p MTR TDG PMC5954032__F1 PI3K/AKT/mTOR/S6K pathway plays a major role in the control of immune cell homeostasis PTEN CTLA4 DEPTOR EIF4B RHEB ICOS CD19 PMC11558907__F2 Function and main molecular mechanism of various adipokines on myocardial ischemia/reperfusion (I/R) injury HMGB1 CGAS ULK1 TLR4 CAP1 IRAK2 DUSP26 METRNL SIRT1 STAT3 CD36 PMC12062509__F7 Cancer-related pathways in cuproptosis FDX1 LIAS ATP7B SLC7A11 ATP7A AARS1 SLC11A2 SLC31A1 TCF4 AARS2 HEL-S-162eP PMC3944211__F1 Bone morphogenetic protein signaling in nephron progenitor cells FOS ATF2 MAP3K7IP1 JUN PMC12062509__F6 Cuproptosis FDX1 LIAS ATP7B ATP7A FES SLC11A2 UFD1L SLC31A1 DLAT GCSH PMC8570568__F3 An ageing innate immune system may predispose a patient to severe COVID-19 NLRP3 PDC IL16 CXCL10 IL6 CCL2 TNF ACE2 PMC12062509__F4 Copper-induced cell death ULK1 GPX4 BAK1 SLC7A11 AIFM1 RIPK3 MTOR XBP1 SLC31A1 DKFZp686F0183 GSDMD NLRP3 RIPK1 TLR4 TFEB ATP7A ERN1 MLKL BAX PMC12062509__F3 Copper in promoting tumor PDE3B ULK1 EGFR APC PARP1 ULK2 MTOR SLC31A1 DKFZp686F0183 CRIP2 MMP14 MMP2 ATOX1 PMC7947037__F2 Betaine and choline status modify the effect of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults HEL-S-61p HEL-S-182mP MTR PC HEL-S-20 GAA PEMT SLC19A1 PMC4268103__F1 Emerging roles of Notch signaling in liver disease NUMB MYC ADAM10 SOX9 PMC4412274__F2 Mechanical forces influence growth rate LATS1 PMC4693579__F2 GLP‐1 and Wnt signalling in the regulation of bone formation (A) In the inactive state of the Wnt/B‐catenin pathway, Wnt is inhibited by a decoy receptor sFRP, where as its co‐receptor LRP5/6 binds to inhibitory protein sclerostin or Dkk APC SOST LRP5 LPL LRP6 FRAT1 PMC8416891__F4 Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Stimulated by Mycobacterium tuberculosis PPE57 Identifies Characteristic Genes Associated With Type I Interferon Signaling ISG15 NFKBIA IFIT2 OAS2 OAS3 STAT2 NFKB1 TNF TRIM25 MX2 PMC11062136__F1 Graphical model illustrating the complex roles of Cytokinin Response Factors (CRFs) in the trade-off between abiotic stress response and plant developmental processes PIN1 PMC8072655__F2 Nrf2 in Hearing Loss GCLC NQO1 PMC5566872__F8 Microglial responses to ischemia/reperfusion based on our in vitro and in vivo datasets STAT1 OAS3 TLR4 STAT2 IRF9 CXCL10 CCL5 IFNAR1 MX2 CCL16 USP18 PMC4233146__F1 Dendritic Cells and B cells: Unexpected Partners in Th2 development CXCL13 LTA BCR CXCR5 IL2 CD80 LTBR GATA3 ICOS PMC8742232__F3 Advances in the study of CDC42 in the female reproductive system ING3 ARHA RAN CDC42 PMC8742232__F2 Advances in the study of CDC42 in the female reproductive system NOBOX MDM2 PTEN PMC7090118__F3 Hedgehog pathway activation through the primary cilium SUFU PTCH1 SMO PMC2933688__F3 EGFR signaling and NHEJ EGF EGFR PTEN TGFA PMC9435021__F3 Biological and neurological activities of astaxanthin MAF CASP3 GCLM BAD TRADD GCLC CASP9 TNF BAX PMC4700624__F2 Changes in the representation of IGF-Akt pathway TSC2 RPS6KB1 TSC1 IGF1R IGF1 RHEB PMC12104183__F4 Signaling pathways involved in the protection of H2S against PH PMC3359746__F1 Several growth factor signals activate cell membrane receptor tyrosine kinases leading to activation of downstream interacting signal transduction pathways (PI3K/AKT, RAF/MAPK, and MTOR) TSC2 BAD TSC1 MYC GRB2 SHE BCL2 PTEN RPS6 MTOR RHEB PMC3081824__F5 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing GMDS SLC35C1 FUCA2 FUT1 FUT4 POFUT4 FUT5 FPGT hCG_1998026 POFUT2 FUCA1 POFUT3 POFUT1 FUT8 FUT9 PMC7536854__F2 Intracellular signaling pathways govern cell growth and proliferation TSC2 TSC1 SLC38A9 MAF1 EIF4E TF RHEB PMC8275986__F1 Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation AMOTL1 LATS1 INF2 LATS2 PMC9180620__F6 Could a Lower Toll-like Receptor (TLR) and NFKB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron? TLR7 TLR4 IRF7 IRF3 FURIN MYD88 TNF ACE2 TLR3 TMPRSS2 PMC3081824__F3 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing NEU4 ST3GAL3 NEU1 ST8SIA5 ST8SIA6 ST8SIA2 ST3GAL6 SIAT4C CMAS SLC35A1 NANS NEU3 NANP ST6GAL2 GNE NEU2 ST8SIA4 ST8SIA1 ST6GALNAC6 SLC17A5 ST3GAL1 ST6GALNAC2 ST6GALNAC1 ST3GAL5 ST6GAL1 PMC6985874__F1 SCF is highly expressed in IPF lungs and blood NFKBIA PIM1 FRK ITGAV CSA2 RPL7 MEF2C KLF1 PS1TP5BP1 STAT3 PMC7176996__F5 Involvement of angelicin in several apoptotic pathways which promote cancer cell death APAF1 EGFR MTOR FADD PMC8966512__F1 Intestinal Wnt in the transition from physiology to oncology APC LRP5 LRP6 DKK1 BCL9 PMC3404158__F2A Ubiquitination and Phosphorylation in the Regulation of NOD2 signaling and NOD2-mediated Disease NOD2 TAB3 PMC5293764__F1 Carbohydrate metabolism in I FH ACAD9 HEL107 HEL-S-68p HEL-S-162eP PMC6939200__EV5 Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor AMOT STXBP4 PMC2397440__F8 Possible role of AICAR and compound C on the AMPK pathway and on glycolysis in CT-2A and astrocytes under low glucose conditions TSC2 MTOR COMP PMC7351732__F3 MYC regulation of essential amino acid and lipid metabolism SLC7A5 KYNU KMO AFMID ACLY CIT HMGCR FASN PMC7351732__F4 MYC coordinates multiple metabolic events to activate nucleotide metabolism OMP PHGDH MTR PSAT1 SRM IMPDH1 PSPH IMPDH2 CAD DHODH ARG1 HEL107 SMS PMC8945563__F2 Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments TBK1 CGAS MAVS PMC7846573__F7 FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability UBL5 FANCD2 ATF4 PMC3940969__F2 TLR signaling pathways in cerebral IT LTA TLR7 TLR4 TLR9 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 TLR1 TIRAP PMC12089955__F5 Proposed mechanisms of action for L. sakei LB-P12 in OA TNF PMC7753186__F2 Mechanisms involved in SARS-CoV-2 infection delineating an ACE/ACE2-ATR1-Cholesterol-HDAC axis IL6 ACE2 PMC9318366__F6 Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NFKB Signaling Pathway In Vivo GCA MPO PMC3532163__F4 Characterization of the Phosphoproteome in SLE Patients CD14 NLK EGF MOS NGF MAX EGFR ECSIT TNF BDNF TRAF2 JUN PMC9085228__F3 miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer TH ALK FAM83D WAS MTOR PMC5610219__F2 Multiple miRNA biogenesis pathways AGO1 AGO2 AGO4 DROSHA NTS PHAX XPO5 PMC3748257__F2 STAT signaling in mammary gland differentiation, cell survival and tumorigenesis MUC1 STAT1 PMC4057083__F8 On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio CXCR3 FGFR1 NGFR CXCR4 CCR7 GRB2 FGFR3 PLXNA3 JAK3 CHRM2 FGFR2 PMC9142129__F6 Inference of Molecular Regulatory Systems Using Statistical Path-Consistency Algorithm NF1 CD14 PAK1 MAX GRB2 TRAF6 GCK JUND ECSIT RAF1 MAP3K7IP1 TRAF2 PMC8067389__F3 HCMV dysregulates the Notch signaling pathway HES5 SOX2 JAG2 NOTCH1 STAT3 HES1 PMC8067389__F2 HCMV regulates the canonical Wnt/Beta-catenin signaling pathway APC PMC3131147__F2 Possible pathways to androgen independence and the involvement of ANG EIF4E MTOR PMC7330701__F4 Schematic that illustrates the hypothesis of how the interferon tau (IFN-τ) acts on positive HPV 16 tumor cells STAT1 STAT2 STAT4 TYK2 IFNAR2 RAC1 RAF1 JAK1 IFNAR1 STAT3 PMC5372499__F3 USP15 acts as a “biological thermostat” in the TGFB signaling pathway USP15 SMURF2 PMC10886030__F4 Oxidative inactivation of PTEN in insulin-related metabolism and muscle differentiation EGF PTEN MTOR PMC5385041__F4 Diagram of glycolysis is shown, including enzymes whose transcripts were more highly expressed in GRMD (red) or wild type dogs (green) FBP2 PGM2 FBP1 ENO1 PYGB HEL-S-68p HEL-S-26 SLC25A12 SLC25A11 GOT2 LDHD F2 MPC1 MPC2 SLC17A5 HEL107 PMC6356247__F2 Effects of chemotherapy on coagulation activation PC APC TF PMC8108341__F9 Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9 LEF1 TIMELESS CCND1 PMC6533072__F3 Estrogen biosynthesis pathway CYP11A1 HSD3B2 HSD17B1 CYP17A1 PMC5770148__F1 Tibim1 reduces TLR4-dependent liver damage TLR4 TMBIM1 TUB PMC8620763__F1 Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study UGT1A3 ACSM2B CYP2C9 HEL-S-303 BCHE HEL-S-5 PMC7482583__F1 LRRK2’s potential involvement in pre- and post-synaptic pathways VPS35 SNAPIN LRRK2 PMC2518463__F2 Binding of specific signalling proteins to phosphorylated tyrosine residues on KIT following receptor activation and the subsequent signalling events leading to mast cell responses STAT1 KIT BTK FYN LYN GRB2 CRK STAT3 PMC6063270__F6 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution PGM2 GAL PMC4104311__F2 Small System—High-Resolution Study of Metabolic Adaptation in the Central Metabolic Pathway to Temperate Climates in Drosophila melanogaster PC HEXA GOT2 TREH HEL-S-304 SDHD HEL-S-32 MDH2 PMC6063270__F1 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution PGM2 GAL PMC8235519__F8 Comparative Analysis of Flavonoid Metabolites in Foxtail Millet (Setaria italica) with Different Eating Quality MMD AMH NMB PMC8473084__F5 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response ISG15 CYLD BCL2 POR UBE2L6 MAVS MX2 MX1 USP18 PMC8473084__F4 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response EZH2 OTP LAT AEBP2 EED PMC6541219__F1 Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement PDE4D PTH TRPS1 TF PMC2939609__F3 Molecular interactomes and sub-networks associated with tumor cell susceptibility to arsenic trioxide CTBP2 SDC1 NASP LPAR2 ARID2 NOL3 FLNB ID1 E2F3 GRB7 ARID1A IRF6 AMFR HTATIP2 KLF4 TPD52L1 MSX2 PPARG HMGN2 PLEKHO1 LAMC2 IFI16 VAV2 PMC9267007__F1 Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair EPOR EPO BCR STAT3 BAX PMC4028332__F2 After the banquet PINK1 PRKAA2 HEL159 PPARGC1A LONP1 MYC ZNF746 YY1 MAPK1 TFAM SIRT1 PMC5050441__F33 Multitargeted modulation of estrogen carcinogenesis by botanicals AHR KEAP1 MAL PMC7595250__F2 Cellular signaling pathways involved in cell senescence in renal ageing CDK2 GSK3B CDK4 WNT9A SIRT1 CDK6 PMC8860249__F2 Emerging Roles of Pellino Family in Pattern Recognition Receptor Signaling TLR4 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 REL DKFZp781O1323 PMC9179306__F5 Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat FGF21 OTUB2 IVL HMOX1 PPP1R15A KRT27 DUSP14 LAP3 FGF22 KRT39 PRR9 TGM3 MALL TCHH PSORS1C2 TGM7 KRTAP3-1 KRTAP11-1 FABP9 PPIF KRT74 CRNN GPRC5D ZRANB1 KRT9 ASL PMC6587965__F1 Cellular Signaling Pathways Modulated by Low-intensity Extracorporeal Shock Wave Therapy TSC2 SRC MTOR BDNF PMC9326486__F1 Therapeutic Potential of Targeting NIK in B Cell Malignancies TRAF3 RELB TRAF2 PMC6299370__F1 The activation of Wnt/Beta-catenin signaling by different oncogenic lncRNAs in liver cancer APC CTCF GSK3B CTNNBIP1 PMC4517123__F2 Innate immune sensing of rhabdovirus infection TBK1 TANK IRF7 TRAF3 IRF3 FADD PMC9097822__F1 Signalling dynamics, cell decisions, and homeostatic control in health and disease EREG EGF EPGN NRG3 FOS AREG NRG2 HBEGF NRG1 BTC CCND1 TGFA NRG4 PMC4999628__F5 A model for a role for AIISp in the repair of DNA ICLs FANCD2 ERCC1 FANCG PMC6485480__F1 Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers GCNT3 ST3GAL3 B4GALT5 EXT1 ST3GAL6 B3GNT5 EXTL1 B4GALT1 GCNT4 B3GALT6 HS6ST1 HS2ST1 HEL-S-75 C1GALT1 XYLT1 EXT2 FUT4 FUT6 GCNT1 FUT5 CHST4 FUT7 FUT3 HS3ST1 UGCG NDST3 ST3GAL1 FUT9 ST6GALNAC2 B3GAT1 ST6GALNAC1 GCNT2 PMC4213475__F2 Model of the JAK-STAT pathway in CRC with the corresponding significant changes in the signaling circuit activities CISH SOCS4 MYC STATH CBLC PMC4213475__F4 Signaling changes in the T-Cell receptor signaling pathway of human bone marrow hematopoietic stem cells FOS ARHA IKBKB PTPRC ITK LCP2 FYN LCK GRB2 CD40LG CBLC LAT CRB2 ICOS PMC2716793__F3 Spatial complexity and control of a bacterial cell cycle PERP POLE PLEC PMC10311615__F11 18Beta-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway SQSTM1 MTOR NBR1 PMC9018123__F4 Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis JUP CAP1 COMP PMC8000623__F2 Summary of survival tactics of MAH within phagocytes from host innate immune effectors MAH infection ARCN1 JUN STX8 AP3B1 CTSZ PMC12205806__F1 Part 1: The process of HBV infection and replication in cells: (A) HBV enters the liver cell via fusion and endocytosis LPP PMC5026573__F6 JNK pathway activation modulates acquired resistance to EGFR/HER2 targeted therapies IGF1R EGFR UNK PMC6637517__F6 Model depicting cascade of the anti-inflammatory effect of ciprofloxacin and levofloxacin, targeting TLR4–MD-2 complex CD14 TLR4 LBP IL1B PMC2949900__F4 Cell Cycle Pathway: Differentially expressed genes involved in the cell cycle are shown in pink PI3 MALL CDK2 SMAD2 SMAD4 SAE1 CDC2 RAD21 PCNA SKP2 PMC6425072__F2 Neurotrophic factors and their receptors in dopamine neurons CNTF RET CDNF GDF15 LIF CNTFR GDNF BDNF GFRAL NRTN PMC6716105__F7 Mechanism of the NFKB Signaling Pathway Mediated by LINC01093Overexpression of LINC01093 can target ICAM-1 negatively and then inhibit apoptosis and enhance proliferation by suppressing the NFKB signaling pathway, thereby attenuating AH CASP3 BAX PMC10755684__F2 Neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance CSF3 NTS CSF1 PMC10853261__F8 Proposed model of GC-induced adiposity UCP1 PTGS2 SIN3A KLF9 KIF9 ARG1 STAT3 PMC2929731__F8 cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways AQP3 AQP5 AQP4 VIP CFTR NAV2 PMC3733265__F1 Mimicking the BH3 domain to kill cancer cells BAD BMF BAX PMC3072784__F8 A kinase cascade regulating pIgR transcytosis RAB11A EGFR PIGR PIGA PMC4530307__F1 “aggressive pathway.” Up-regulated genes (red) and downregulated genes (blue) are interconnected in a pathway involved in cell cycle control CDCA5 MYC CD44 CENPE CDKN2A DBF4 CENPK AURKB TSG101 HTATIP2 HMMR CCNB2 CCNB1 DGKZ THBS1 PTTG1 PMC7927668__F5 KEGG mTOR signaling pathway map comparing +AMR/+DSA and +DSA vs TH MOS MIOS RNF152 PTEN PMC5345234__F9 IL2RG-centered gene subnetwork EPOR MED12 IGF1R HCFC1 REN DLG2 VAV1 ERBB3 CSF3R SPN PRELP PTPN22 BRS3 TRIM14 TAP2 DHRS7 ZMIZ2 PARP11 IL2RG PTPN11 RGS1 IL-21 PMC8451771__F3 Apoptosis – Fueling the oncogenic fire CGAS RAC1 CDC42 STAT3 PMC8466405__F4 Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome IL6 MYD88 TIRAP PMC2612938__F2 Pathways by which Mgrn1-mediated ubiquitination could modulate melanocortin receptor regulation of pigment production and energy metabolism MGRN1 ATM AgRP MC4R MC3R MC1R PMC8468592__F2 Glucocorticoid and PD-1 Cross-Talk: Does the Immune System Become Confused? CDK2 APC PTEN GATA3 PMC5589626__F7 Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRA/AKT cascade restrains tuberous sclerosis complex-associated tumor development TSC2 TSC1 PDGFRA PTEN MTOR DEPTOR IRS1 MLST8 PMC5995077__F7 DMix regulates hepatic gluconeogenesis in diabetic rats via the PI3K/Akt signaling pathway INS FOXO1 INSR PMC7775273__F5 Mechanical Regulation of Apoptosis in the Cardiovascular System CASP3 TRADD CASP9 CASP10 CASP8 FADD PMC4825184__F1 TLR and NLR pathways driving pro-inflammatory state after exposure to extracellular and Intracellular microbial products TLR5 NOD1 MYD88 PMC4641903__F2 Summary of the roles of alpha-synuclein and other PD-associated proteins in the secretory pathway and the resulting stress responses RAB1A PINK1 LRRK2 RAB11A CDK5 RAB1B ARF4 BAG5 XBP1 PMC3654375__F3 Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning ARHA SHB RAC1 PMC8411019__F2 Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders GPR32 FPR2 RORA LGR6 GPR37 PMC3983859__F6 Schematic representation of the RvD1 contribution to microglia alternative activation FPR2 ARG1 PMC5510550__F1 Negative Regulation of Type 2 Immunity IL33 IL25 TSLP PMC4280507__F4 One carbon metabolism and the effects of alcohol (EtOH) and nutrition throughout the metabolical pathway HEL-S-182mP MTR HEL-S-64p DHFR CP PMC3674144__F1 New look at TCR signaling to NFKB BCL10 CYLD HOMER3 RELB TRAF6 TRAF2 MIB2 PMC6478801__F8 SNG mediated action in MM cells HEL-S-62p C9 BCL2 STAT3 BAX PMC7280204__F8 Signaling pathways involved in osteocyte mechanobiology PTGER2 CTSK SMAD2 SOST PTGER4 SRC RHO FRAT1 PMC4358122__F5 Reciprocal regulation of AMPK and PLD TSC2 TSC1 RHEB PMC4367691__F1 ROR1 signaling pathway EGF BRAF ERBB3 EGFR NRG1 PTEN JAK1 ROR1 STAT3 PMC6329812__F2 The stress adaptive processes induced by mutant p53 trigger positive loops feeding its own accumulation in cancer cells MDM2 ARHA HSF1 PMC4931093__F1 Mechanotransduction in transcriptional regulation AMOT ARHA MAL PMC4237867__F1 Signaling pathway of toll-like receptors (TLRs) TBK1 TLR8 TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TLR1 TLR3 TIRAP PMC2895650__F1 Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility STS HSD11B1 NAT1 NAT2 UGT2B4 HEL-S-22 PMC6080105__F1 Short and Long Noncoding RNAs Regulate the Epigenetic Status of Cells AGO1 CSDC2 EZH2 NOTCH3 POLR3D PMC3943799__F2 Cytosolic DNA sensing pathways IRF7 DHX36 DDX41 IRF3 MYD88 AIM2 MAVS IFI16 PMC3819657__F3 Combined miRNA/mRNA regulatory and functional enrichment network DKFZp686L0365 PIK3CD EREG PIM1 SOCS3 RUNX1 CMPK2 COL8A1 PMC4880707__F1 Suggested positive feedback loop in SOD3 signal transduction FYN BRAF LYN VEGFA SRC PMC5580463__F4 PI3K/AKT and RAS/EGFR/ERK pathways BAD TSC1 ERBB2 ERBB3 EGFR MDM2 GRB2 PTEN MTOR PMC5338029__F5 Syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFB and Activin pathways TSHB IGSF1 SMAD2 TRH SMAD4 FSHB FSHR TRHR TGFB1 PMC5622428__F4 Network based on a restricted number of genes after selection of topological parameters VEGFA BCL2 CASP2 OSTC PMC8297972__F1 Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease COX1 IL33 FPR2 PMC4445728__F1 Development and in vivo function of TH9 cells TH APC STAT4 IFNG STAT3 PMC6710335__F8 The working model of Tpl2 in protecting against fulminant hepatitis CXCL1 CXCL2 IL25 PMC6595474__F8 Summary of mechanisms by which exosomes from cyclic stretch-exposed PDL cells negatively regulate IL-1B production in macrophages NLRP3 TLR4 IL1B PMC5711888__F3 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis SMAD2 WNT7A VEGFD SMAD6 VEGFA NRARP VEGFC BMP10 NRP1 SRC KLF2 SMAD1 TGFB1 STAT3 PMC5711888__F2 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis TRPV4 PIEZO1 WNT1 VEGFD NRARP SMAD4 TRAF6 RYK PTEN MTOR FGFR2 ADAM17 NF1 FYN NOTCH1 SRC CCND1 SFRP1 AXIN2 AXL PIGF NOTCH4 APC SMAD6 VEGFA SPRED1 ENG TSC2 VEGFC DAAM1 TSC1 BMP10 CLK4 AXIN1 ADAM10 KLF2 TGFBI CDC42 PMC6343099__F2 Regulated signal pathways and transcription factors of NCX1 in digestive diseases TRPC1 SMAD4 TRPC6 PMC8967572__F4 Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer KEAP1 ATM ATR CGN PMC8602556__F1 Crosstalk Between ER Stress, Autophagy and Inflammation TBK1 NLRP3 ATF4 EIF2A IRF3 TXNIP ATF5 ATF6B TRAF2 IL1B PMC2394752__F4 Contextual organization of the NFKB positive modulators SLC7A10 TNFRSF12A TROAP TM7SF2 TNFRSF11A GPR108 SNX16 PLEK2 SLC22A7 DUT GPD1 MAP3K7 SSBP2 TNF RBM6 CYBB MLX ADAR TNFRSF1B GNA15 EGR2 TNFRSF1A PAAT CCNL2 TYRO3 MAP3K14 ATP2A2 TNFRSF10A CCL22 GJB6 PYCARD IKBKG GDA NUTF2 PAK4 MBD2 MASTL TRAPPC1 PLK2 CAMK2D HSBP1 RRAS ZNF443 B3GALT4 OPHN1 ST13 IKBKB TNFRSF25 BIRC2 SLC19A2 LTA ACADVL TNFSF10 CD40 PHYH NET1 TNFRSF10B RAN TRAF2 FADD PLEKHB1 TIRAP PMC12027414__F6 Impact of NPC86 on insulin signaling and inflammatory pathways in adipose tissue BAD SOCS3 PHKA1 ACACA SOST GSK3B INS EIF4EBP1 MTOR INPP5A TRIP10 PYGM RPTOR INSR AK2 EXOC7 G6PC3 ARAF HK2 PRKAB1 FASN PRKCI INPP1 PDE3B INPPL1 FBP2 MAPK10 GYS1 SH2B2 HRAS PIK3R3 CRK FOXO1 PTPRF RHEB CBL TSC2 GYS2 LIPE TSC1 MAP2K1 HEL-S-42 GRB2 SOS1 PMC6139039__F1 Stabilizing and destabilizing signals for Tregs NRP1 PTEN CTLA4 IFNG FOXP3 PMC8784108__F4 Insight into the symbiotic lifestyle of DPANN archaea revealed by cultivation and genome analyses FEN1 POLD2 TBP PMC10548218__F1 FGF effects in breast cancer cells FRS2 FGF2 FGF10 GRB2 FGF7 FGF9 PMC4523312__F2 Protein interaction pathway produced by combining known protein–protein interactions from the literature BAD FOS ATF2 PTEN RHO MTOR IRS1 CCND1 BCL2 MCL1 STAT3 CDC42 BAX PMC7306315__F1 Iron homeostasis and signaling pathways involved in hepcidin regulation ERFE EPO HAMP PMC5512429__F3 Cellular signaling pathways and transcriptional regulatory circuits mediating physiologic cardiac hypertrophic growth CITED4 PI3 NRF1 IGF1 IRS1 PMC9032101__F1 Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders ELF2 EDEM1 ATF4 BDNF PMC3479160__F5 PPI subnetworks of the extended disease pathways EGF BAD HGF BACE2 GSK3B PTEN FZD1 HSD17B10 NAE1 FZD9 A2M PDGFA E2F2 LPL FZD2 CCND1 MSH3 MSH2 JUN IL1B APOE BAX SNCA HRG PSEN2 FGF6 TCF7L2 FGF13 NEDD8 FZD4 FGF12 FZD5 HEL-S-162eP FER PDGFC IGF1 MUTYH APC2 PSENEN CYCS PMC8977417__F2 Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer HEL-S-92n CD80 MTOR SPDL1 PMC7954751__F9 Hormonal regulation of human DNA methyl transferases GC F3 SRC PTH DNMT3B PMC6745489__F5 Rectal cancer sub-clones respond differentially to neoadjuvant therapy HIPK2 C1QBP DES PTEN TTN MAD2L2 EIF3E SYNE1 POLE4 MNT BCR HTT LPL CCL28 RNPS1 UPF3A PRRC2A PIGT MYPN P4HA2 POLK SETDB1 APC SPTB GPAA1 DDX39B MAX PRMT2 ALYREF TRPC5 CPSF1 TRPC3 SRPK2 SRSF6 PMC6128733__F1 Neurotrophin Trafficking via Trk Receptors SNAPIN NGF RAC1 MEF2D PMC3902842__F3 Molecular mechanisms involved in leptin receptor signaling in the hypothalamus STAT3 PMC8261751__F2 Coronavirus disease and the cardiovascular system: a narrative review of the mechanisms of injury and management implications ACE2 PMC3234335__F1 Hereditary Hemochromatosis and Transferrin Receptor 2 BMP6 HAMP SMAD4 HFE IL6 IL6R SMAD1 TF DKFZp781O1323 TFR2 STAT3 PMC12071082__F3 Therapies targeting RASGAPs in urological cancers ATM DAB2IP EZH2 PMC6128733__F2 Neurotrophin Trafficking via Trk Receptors NGF SNX26 KIF1A RAB27B PMC11007187__F4 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies TSC2 TSC1 GRB2 PTEN MTOR BDNF SIRT1 RHEB PMC11007187__F1 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies AGO1 AGO2 AGO4 DROSHA RAN PMC8615487__F2 An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes SIRT2 MARK4 MYD88 XBP1 UCP2 TET2 SIRT3 NLRP3 IL16 ELF3 RELA TXNIP STAT3 BRD4 PMC4033011__F2 Possible pathways for LRP1-mediated AB uptake ARHA RAC1 PMC4650429__F1 During normal cellular conditions, BRD4 recognizes acetylated lysine residues on histones and recruits positive transcription elongation factor b (P-TEFb) to promote transcriptional elongation by RNA polymerase II of key oncogenic drivers such as MYC MYC BRD4 PMC7609776__F4 KEGG AD pathway including Cd-associated transcripts in males CASP3 SNCA CASP12 BAD APAF1 LPL CASP9 APP TNF FADD APOE PMC11860889__F1 Activation or silencing of WNT signaling pathway in the presence or absence of WNT ligands 1 TWIST1 APC LRP5 LRP6 PMC7783665__F1 Calcineurin-NFAT pathway for expression of cytokines and cell membrane proteins IL2 CD40 PLCG2 PMC6412382__F1 Mammalian target of rapamycin (mTOR) regulatory network RRAGD ULK1 FLCN CHUK ETV7 INS TBC1D7 CASTOR1 AKT1S1 PRRT2 PTEN EIF4EBP1 MTOR LPIN1 RRAGB APP RPS6 EIF4B SGK1 PRKAA2 SLC38A9 EIF4E DEPTOR IRS1 RHEB MLST8 IKBKB TSC2 TTI1 SLC7A5 RICTOR RHOD RPS6KB1 TSC1 TNFRSF1A GRB2 FNIP1 PIK3CA GRB10 RRAGA PMC7783665__F4 Calcineurin activation by cAMP/PKA and interaction with CaM for cell secretion S100A10 ANXA2 VWF CFTR PMC3562392__F3 Cytoscape diagram of the functional interaction network representing proteins modulation in Pt1 interstitial fluid FGA MYO1C ALB HEL-S-101 AMBP SPTB SPTA1 APOB HEL-S-78p ARHGAP4 LSM7 EIF3M SP4 SERPINA1 HEL113 PMC4997298__F6 Upstream regulatory analysis of weight-loss–associated genes identified strong C/EBPA activation LEP SERPINI1 EPHX1 SCD PPL ACACA NRP1 CEBPA HEL114 ACLY TUBB2A PMC4200329__F4 Schematic representation of the amniotic fluid eicosanoid profile LTB PMC12012437__F1 S100P signaling pathways associated with proliferation, apoptosis, migration, invasion and EMT in tumors STAT1 S100P BCL10 KEAP1 ATF4 SMAD4 SIX3 TXNIP TRIM27 SOX9 PMC10740567__F1 Signaling pathways involved in the inhibition of apoptosis by Apicomplexan protozoa TRADD APAF1 EGFR TNF TRAF2 FADD STAT3 BAX PMC12012437__F2 S100P signaling pathways associated with angiogenesis, cell cycle and drug resistance in tumors S100P TFF1 LPXN PMC5531310__F3 Glycolysis is downregulated in idiopathic pulmonary fibrosis (IPF) lungs, with possible shuttling of intermediates to the sorbitol and pentose phosphate pathways G6PC3 SLC2A4RG PGAM1 PMC5531310__F2 Arginine metabolism is increased in the idiopathic pulmonary fibrosis (IPF) lung ARG2 ARG1 PMC5531310__F1 Downregulated sphingolipid metabolism in idiopathic pulmonary fibrosis (IPF) lungs SMPD4 ACER3 S1PR1 SMPD1 SPHK1 S1PR4 DEGS1 PMC8537973__F10 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations TBL1XR1 NRF1 MMP11 MYL6 RAP2A DLG4 HES1 GNB3 MMP2 ATF4 CCND1 SP1 JUN SDHC FOS ARHA ENG HRAS PIK3C2B MED14 PDGFC IGF1 NFKB2 SETD7 HEL-S-269 PRKAG2 MED13 JAK3 NDUFA10 VEGFB PIK3R2 PMC2268699__F2 FGF canonical signalling pathway MAPKAPK2 CRK STAT3 PMC2268699__F1 p38 MAPK canonical signalling pathway STAT1 MAPKAPK2 MAX TRADD ATF2 TRAF6 MAPKAPK3 MAP3K7IP1 TRAF2 FADD PMC7112453__F1 NAD+ metabolism pathways in mammals NAPRT NAMPT HEL-S-90n NADK NMNAT2 NMNAT3 NRK PMC8939237__F1 Regulatory Pathways Governing Metabolic Control of Puberty Discerned from Rodent, Nonhuman Primate, and Human Studies SHBG ARC MTOR SIRT1 EED PMC3783495__F7 Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression TLR4 MYD88 ABCA1 PMC3901678__F6 Mining Gene Expression Data for Pollutants (Dioxin, Toluene, Formaldehyde) and Low Dose of Gamma-Irradiation DCT WAS SYP PMC10478265__F2 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer CGAS CXCL10 CXCL9 IRF3 PMC10478265__F1 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer CGAS IRF3 TNF PMC5915650__F7 Proposed mechanotransduction mechanism RUNX2 BMP2 RHO PMC6562751__F2 Signaling Pathways and Cellular Processes Regulated by Keratins, Vimentin, and Nestin TRADD SMAD2 EGFR GSK3B CDK5 AIRE RAC1 MTOR HRAS TSC2 CXCR3 NLRP3 TSC1 FGFR1 SRC SP1 AXL SP3 STAT3 PMC5768180__F7 Interferon regulatory factor 5 regulates B cell proliferation and cell cycle HEL2 HDAC7 APC MPP2 CDC20 MCM2 ATM CDK2 E2F2 ATR HEL-S-93 PRKDC YWHAG PCNA RBL1 SKP2 PMC8235370__F1 Coronavirus RNA-Processing Enzymes in Innate Immune Evasion STAT1 STAT2 IRF9 PMC3714203__F2 DR4 and DR5 Agonistic mAb-induced Apoptosis: Regulation of TRAIL/Apo2L Resistance by HDACi BAD BIK DIABLO PMC8705212__F4 Camptothecin Encapsulated in Beta-Cyclodextrin-EDTA-Fe3O4 Nanoparticles Induce Metabolic Reprogramming Repair in HT29 Cancer Cells through Epigenetic Modulation: A Bioinformatics Approach TIGAR PYCR2 FH PAICS ACLY HEL107 PMC8918554__F9 The functions of NR2F1-AS1 in pancreatic cancer NR2F1 MTOR PMC10540332__F7 Combined transcriptomic and metabolomic analysis of alginate oligosaccharides alleviating salt stress in rice seedlings LAP3 PMC3627976__F1 The polyamine pathway SRM AMD1 SMS PMC4892997__F1 Antiviral Innate Immunity through the lens of Systems Biology TBK1 CGAS IFIT2 STAT2 IRF7 IRF9 DHX36 RIGI IRF3 IFNAR2 IFNAR1 NOD2 IFNLR1 USP18 RNASEL RNASE1 TLR4 TYK2 MAVS IFI16 IFIT1 PMC8297769__F7 Summary and model of synergistic myocardial infarct size reduction by IPC in cardiac-specific SOCS3-deficient mice SOCS3 EPO STAT3 PMC12092085__F4 Biodegradable magnesium-based implants inhibit osteoclast differentiation through multiple mechanisms TRAF5 NFATC1 TRAF6 TRAF2 PMC3619548__F1 Schematic summary of the most common mutations found in melanoma patients BRAF PTEN CDKN2A PMC6425966__F3 Examples of prediction by eQTL signal convergence across distinct chromosomes KCNK7 CD40 FCGR2C PMC12092085__F8 PTH reduces the binding of RANKL to OPG by inhibiting the secretion of OPG from osteoblasts and acting on the cAMP-PKA-CREB and PP1/PP2A-CRTC3 pathways SIK2 SIK3 PTH JUN CRTC3 PMC12092085__F1 Magnesium promotes osteogenesis MSC SP7 TRPM7 PMC8394846__F1 NFKB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models CYLD LTB RELB REL PMC3410583__F3 Pathways of autophagy induction by hypoxia and mutant RAS ATF4 BNIP3L BNIP3 HIF1A MTOR DKFZp686F0183 PMC3460904__F7 Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours FST GIG8 NODAL SMAD2 SMURF2 SMAD6 SMAD4 SMURF1 ID1 ID3 INHBA PMC3509664__F3 PKR and the Insulin signaling pathway TSC2 EIF4E MTOR IRS1 PMC5382109__F6 Therapeutic targets in B cell lymphoma of NFKB activation BTK BCR FOS LYN SYK MYD88 CSA2 CD79B PMC3928598__F1 Protein O-linked ß-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function OGA OGT PMC4589285__F11 Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney BMPR2 TLR4 EGFR TGFBR1 HRAS JUN HEL-S-31 FADD PMC3509664__F8 PKR, ISG15 as modulators of IFN induction during HCV infection ISG15 EIF2A TRAF3 IRF3 TRIM25 MAVS PMC5382109__F3 Apoptotic pathways of NFKB: TRAIL mediating the extrinsic pathway and p53 mediating the intrinsic pathway APAF1 RELA BAX PMC3509664__F7 HCV and induction of the innate immune response IRF3 TRIM25 TLR3 MAVS PMC5382109__F2 Activation modes of NFKB in the pathogenesis of B cell lymphoma CARD11 BCL10 BASH LYN SYK PTEN CD79A CD19 PMC5382109__F5 Extrinsic and intrinsic signaling of BCR signaling activates NFKB in B-cell malignancies CARD11 BCL10 BCR RELB MYD88 PMC5530905__F1 Action of PPARG ligands and p38 MAPK on transforming growth factor (TGF)B1–induced Beta-catenin signaling in corneal fibroblasts APC GSK3B PMC5901476__F1 Mineral and bone disorders in chronic kidney disease (CKD) FGF23 PTH DKK1 PMC3460238__F1B Central role of AP convertase in complement activation HEL-S-62p CD59 CD46 MBP CD55 CP PMC5382109__F1 Canonical and non-canonical NFKB pathways BTK BCL10 RELA RELB TRAF6 SYK REL CD79B PMC3686839__F2 Molecular Pathways: Extracting Medical Knowledge from High Throughput Genomic Data PIK3R1 NFKBIA MAP3K1 MAP2K4 MAPK8 MYC MAPK14 PIK3CA PTEN JUN CD19 PMC5901476__F3 Proposed mechanisms by which PTH activates Wnt/Beta-catenin pathway in osteoblasts and osteocytes to modulate bone turnover GSK3B PTH PMC7176583__F1 Gastric cancer: genome damaged by bugs COX2 EGR1 NOD1 APC SMOX GSK3B SRC TRAF6 IL1B STAT3 PMC3038050__F1 Mechanisms by which CD44 can modulate cell death ECD CD44 MTOR FADD PMC5320748__F1 Similar signaling cascades involved with neuroprotection for insulin-like peptides and sex hormones BAD IGF1R IGF1 MTOR IRS1 PMC10967781__F2 Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development BAD IGF1R IGF1 IGFBP1 IGF2 IGFBP2 BCL2 IGFBP6 MTOR IGFBP5 PMC10967781__F1 Functional connections between the IR and IGF-R signaling axis IGF1R IGF1 IGF2 IGF2R PMC8626172__F8 Network Pharmacology‐Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae CCNA2 COL3A1 CYP1B1 PTGS2 MMP9 CXCL10 MYC CXCL2 PTGER3 IL6 CCL2 CLDN4 COL1A1 HMOX1 HEL-S-102 PRKCB VCAM1 CCNB1 SELE PMC3568185__F1 PGE2biosynthetic pathway COX2 COX1 PMC4307032__F2 Signaling Molecules: Hydrogen Sulfide and Polysulfide DAO PMC6258792__F4 CREB1 signaling is predicted to be altered by ID EGR1 FOS PTGS2 KLF5 CREB1 CEBPB PDYN EGR4 EGR2 ARC JUNB BTG2 BDNF PMC6282071__F3 Increased P2X4R expression after nerve injury via the actions of fibronectin in activated microglia CCR2 IRF8 LYN MDM2 CCL2 EIF4E CR2 PMC3259815__F8 Signaling through PAK in the hyperosmotic response pathway PTEN CDC42 PMC1892100__F1 Image showing the human insulin signaling pathway from BioCarta GAB2 SOST GRB2 RAF1 IRS1 PMC3180377__F9 Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis TLR4 IRF7 PPARGC1A TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR3 TIRAP PMC7600476__F3 The major cell signaling pathways by resveratrol and/or curcumin in melanoma BRAF MDM2 BCL2 PTEN MTOR STAT3 BAX PMC9587090__F2 Cellular senescence and acute kidney injury CDK2 CCND1 CDK4 CDC2 CDK6 PMC8931477__F1 Natural Products Against Renal Fibrosis via Modulation of SUMOylation SUMO3 SUMO2 SENP6 SENP1 SMAD4 HDAC2 SUMO4 PMC5863447__F2 Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides) GYS2 RETN LIPE ACACA PRKAR1A GRB2 APOD SHC4 SERPINA1 HGFAC APOH FASN PMC7868824__F45 Targeting NFKB mediated cell signaling pathway and inflammatory mediators by 1,2-diazole in A549 cells in vitro TLR4 EGFR PMC3116111__F1 Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell GPX1 RALBP1 TOP2A HEL-S-18 NFKB1 ABCC1 HEL-S-44 XDH ABCG2 MSH2 ERCC2 ABCC2 ABCB1 PMC8563895__F7 B2-adrenergic receptor regulates ER-mitochondria contacts MCU INF2 CDC42 PMC5969912__F3 Once and only once: mechanisms of centriole duplication and their deregulation in disease MDM2 USP28 CASP2 RAC1 LATS2 PMC8157545__F1 Efficacy of BRAF and MEK Inhibition in Patients with BRAF-Mutant Advanced Melanoma and Germline CDKN2A Pathogenic Variants BRAF NRAS MDM2 CDK4 CDK6 PMC11915076__F1 Oncogenic and tumor-suppressive roles of Lipocalin 2 (LCN2) in tumor progression ATF4 LCN2 S1PR1 IL6 IL6R STAT3 PMC3827506__F5 Signaling by innate immune receptors NLRP3 TRAF6 SYK MYD88 NOD2 PMC3217176__F3 Targeting the PI3K/AKT/mTOR pathway BAD GSK3B CCND1 PMC5280876__F3 Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Acute Lung Injury and Other Inflammatory Lung Diseases IGF1R VCAM1 PMC5501684__F6 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection MMP2 FGF2 TGFA PMC5207462__F2 Insulin signaling pathway PI3 GRB2 PMC5501684__F5 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection TH IL18 COA1 CD48 IL4 CP PMC5501684__F4 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection TH CDA HEL-S-11 CD40 IL4 CAD PMC4350910__F3 Pathway for the synthesis of the endocannabinoids AEA and 2-AG FAAH TRPV1 PMC3722525__F7 Antigen processing and presentation pathway and the cell cycle pathway SMAD2 TGFBR1 APC SMAD6 TGFBR2 SMAD4 CD74 SMURF1 LTBP1 IFNG NOG DCN BMPR2 CDC20 SMURF2 SMAD1 DKFZp781O1323 PMC5501684__F7 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection MMP2 TNF TGFA PMC2561291__F1 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions TBK1 IFIT2 SOCS3 IRF7 IRAK1 CXCL10 TRAF6 IRAK4 IRF3 MYD88 TNF HEL-S-162eP TLR4 MAL PMC7941218__F3 GDF‐5 signalling pathway and regulation of GDF‐5 expression GDF5 APC SOX11 MSC GSK3B SMAD4 TRPS1 PITX1 ACAN COL2A1 DKFZp781O1323 PMC5215890__F6 The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans SPO11 SP2 SP4 HUS1 SP1 SP5 SP7 SP3 SP9 PMC7278922__F2 Two distinct Fe/S cluster biosynthetic pathways exist in mitochondria (mitochondrial NFS pathway, left) and plastid (plastidial SUF pathway, right) in Arabidopsis HSCB NFU1 PMC2561291__F5 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions TBK1 TRAF6 MYD88 PMC4449696__F2 Retinoid metabolism and the structure of retinoid receptors RARA RBP4 CDK7 PMC4760086__F2 Inflammation in SCD HMGB1 PIGF CXCL1 TLR4 VCAM1 CXCL10 CXCL9 CXCL8 PMC8009949__F6 Part of C21-steroird biosynthesis pathway HSD3B2 CYP17A1 STAR PMC4486424__F6 Ingenuity Pathways Analysis summary EGF AIP TIMP1 CDKN2B MEIS1 TP73 BCL2L1 WT1 CCNC TGFB1 CASP8 PMC11955613__F5 Pyroptotic osteocytes promote osteoclastogenesis NLRP3 CASP5 GSDMD CASP4 PMC4980649__F1 Main WNT/Beta-catenin pathway involved in cancer and stem cells TCF3 SOX2 APC ESRRB GSK3B CCND1 PMC11955613__F2 Apoptotic and necrotic osteocytes promote osteoclastogenesis CASP3 VEGFA BAX PMC9319258__F5 Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma E2F4 COL3A1 NODAL CSNK2A1 MYC opn CCNB1 COL1A2 MDM2 SP1 PRKDC YWHAG RBL1 CDC23 WASF2 MAP3K7 CD44 ARHA LTBP1 COL6A5 TNC YWHAQ CREBBP HSPG2 CDKN1A SDC4 VTN SMURF2 COL4A1 COL4A5 PMC11955613__F4 Ferroptotic osteocytes promote osteoclastogenesis GPX4 LPCAT3 FACL4 SLC7A11 SLC3A2 PMC4617705__F4 Effects of CsA on the expression of genes involved in endoplasmic reticulum stress and FXR-regulated pathways in WT-PCLS and FXRKO-PCLS APOB PTN ACACA ACD PMC7299245__F1 Targets of new therapeutic options in beta-thalassemia ERFE BMP6 EPO HAMP SMAD2 SMAD4 HFE GDF1 GDF10 PS1TP5BP1 TFR2 GDF11 SMAD1 GDF3 DKFZp781O1323 STAT3 PMC7240957__F8 Mechanism of cytochrome P450 (CYP450)-dependent metabolism of polyunsaturated omega-6 and omega-3 fatty acids involved in CKD progression EPHX3 TES EPHX2 CYP2E1 PMC5846367__F2 Interplay between immune system and gut microbiota in homeostasis, tolerance, and inflammation TH APC IL33 TSLP IFNG PMC3773992__F2 Crosstalk between hedgehog signaling, Wnt/Beta-catenin signaling, notch signaling, and phosphoinositide 3 (PI3)-kinase/Akt pathway and targeting by norcantharidin (NCTD) DKK3 SUFU APC PTCH1 PGP JAG2 LRP5 LRP6 SMO DKK1 PMC7991087__F5 Summarizing Figure TLR4 SREBF2 HMGCR PMC6290143__F2 Role of the APC tumor suppressor gene in signaling expression of genes regulating the polyamine pathway APC FAP MYC PMC6307803__F6 The model of miR‐520b regulating NSCLC tumourigenesis GLI3 SPOP PMC7932307__F2 Nucleic acid immunotherapeutics that can activate the cGAS-STING signaling pathway CGAS IRF3 PMC5454811__F4 Schematic diagrams of (A) the BR biosynthesis pathway, (B) BR signal transduction pathway, and (C) auxin signaling transduction pathway CS BIN2 CPD PMC4031983__F8 MiRNA dependent regulation of DSB repair during cell cycle BRCA2 IMPACT RAD51 BRCA1 PMC3996470__F1 Receptor-mediated endocytic pathway in nonpolarized mammalian cells NPC1 LDLR NPC2 PMC7244267__F4 Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli CIT MAL PMC8882646__F1 Interaction of Mycobacteria With Host Cell Inflammasomes NLRP3 HMGB1 TNF AIM2 GSDMD NINJ1 PMC6541953__F2 Anti-inflammatory and antioxidant mechanisms of neuroprotection and neuronal function by ursolic acid LPO MTOR NQO1 PMC3021128__F7 Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7 MCM3 MCM5 MCM6 MCM2 MCM7 PMC2106369__F1 Schematic overview of the RANK-NFKB signalling pathway TRAF6 VCP MAP3K7IP1 PMC4737002__F1 Regulation of interconnected stem cell signaling nodes by the AR SMAD2 KLF4 CCL5 PTEN STAT3 PMC6536593__F5 Implication of hexosamine biosynthetic pathway on the NLRP3 inflammasome NLRP3 IL16 OGA OGT TXNIP IL1B PMC3694812__F1 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data NRG2 NRG1 CDC42 PMC3694812__F4 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data TPM1 NRG2 NRG1 CDC42 PMC7497261__F1 Different inflammasome complexes: (From left to right) Engagement of different TLR receptors leads to activation of IKKs, which in turn results in activation of NF‐KB signaling NLRP3 HMGB1 NLRC4 NLRP1 PKN2 ARHA AIM2 DPP9 PKN1 GSDMD PMC3419137__F3 Targets of the tumor suppressor gene miR-200 in regulation of the epithelial-mesenchymal transition in cancer SPARC CTSL GGH MERP1 SPON2 TINAGL1 ADAM15 ADAM12 GUGU CTSH NID1 ADAMTS15 CTSZ BMP4 LGALS3BP HEL-S-2 CTSA CDH2 PMC9134136__F2 Ductular reaction in non-alcoholic steatohepatitis HGF GLI3 SMO LATS1 LATS2 PMC4698100__F8 Regulatory functions of STAT3 in cardiac Beta-adrenergic functions CACNA1H ADRB1 SRC STAT3 PMC4850140__F1 Tested Wnt-related genes and proteins and their functions in the canonical Wnt signaling pathway are shown here APC LRP5 LRP6 PMC8273435__F4 The F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases CSK PSTPIP1 PSTPIP2 PMC3585432__F1 The Drosophila Hippo pathway RUNX2 AMOT ZYX F2 LATS2 FRMD6 PMC4669899__F2 Simplified outline of Insulin and AA/TOR signaling pathways TSC2 TSC1 PTEN RHEB PMC3515332__F1 Class I PI3K/Akt/mTOR axis pathway RICTOR BAD PTEN EIF4E IRS1 FOXO1 BAX PMC5475222__F2 Secreted T MBD3 STAT1 EGR1 CAMLG MDM2 ADA TRAF6 CXCL2 PMC5548997__F7 Involvement of BPA, BPS or BPF in the proliferation, EMT, and migration of MCF-7 CV cells via ER-dependent pathway CCND1 CDH2 CCNE1 PMC12121119__F3 Bridging role of hepatokines in AD and metabolic disorders FGF21 ANGPTL3 GPX4 TLR4 SHBG SELENOP SMAD2 CREB1 IFNG PMC6540965__F2 Relationship between middle-age obesity, glutamate excitotoxicity and increased risk of Alzheimer’s disease MTOR STAT3 PMC8704679__F2 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections IRF9 C6 PMC7941705__F2 Anesthetic affect pro- and anti-cancer miRNA expressions leading to cancer biology changes MMP2 GC MMP9 HIF1A PMC9186411__F1 Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus NLRP3 CGAS SLC19A1 PMC8704679__F1 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections TBK1 TANK IRF3 MAVS PMC4363231__F1 Potential canonical WNT signaling pathway- Resting state (a): SFRP4 binds free WNT molecules in the extracellular space and DKK binds the LRP co-receptor SFRP4 RSPO1 APC LRP5 LRP6 DKK1 PMC9256749__F4 Piezo1 channel promotes the tumorigenesis of prostate through the Akt/mTOR pathway (adapted from 111) PIEZO1 CCND1 CDK4 MTOR PMC6737422__F1 SCD-associated oxidative stress pathways and antioxidant systems TLR4 FES NOX4 HEL-S-44 NOX5 PMC5662719__F6 Schematic working hypothesis NLRP3 IL16 SPRY1 ACE2 IL1B PMC7567162__F7 Tripterygium ingredients could inhibit multiple pathways, such as the NFKB pathway, JAK-STAT pathway, and PI3K-mTOR pathway, to regulate the hyperactive as well as pathogenicity biological functions in a various type of cells ( to ) APC IL2 IL6 IL1B PMC6534162__F2 Stimulating Cardiogenesis as a Treatment for Heart Failure CCNA2 NRG1 CDC2 PMC11842143__F1 Developmental signaling pathways regulating osteoblast differentiation RBPJ RUNX2 BMP2 LRP5 SMAD4 LRP6 SMO SMAD1 DKFZp781O1323 SOX9 BMP4 PMC4292999__F5 Co-expression of the Wnt signaling pathway with CITED2 in spondyloarthritis (SpA) WNT1 ROR2 FZD4 WNT10B CITED2 PMC6988322__F5 SMARCD1 nearest-neighbor adjacency subnetwork with the glucocorticoid receptor response pathway CREBBP SMARCA4 EP300 NR3C1 SMARCD1 SGK1 SMARCC2 CP SMARCC1 PMC5733726__F1 Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals STAT1 CXCL1 CARD9 BCL10 EBP RASGRF1 JAK1 HRAS IL23R IL17RC IL1B STAT3 PMC9641109__F7 Identification of candidate hub genes correlated with the pathogenesis, diagnosis, and prognosis of prostate cancer by integrated bioinformatics analysis CCL2 PTGS1 CCND2 KCNMB1 AOX1 COL4A6 PPP1R14A RRM2 COL9A2 HEL114 CAV2 GSTM3 COL2A1 CALD1 SV2B PTGIS NPR2 GSTM5 PTGS2 GSTM1 VEGFA LAMB3 FMO5 THBS4 KCNJ3 HEL-S-22 CALM1 GSTM2 ANGPT1 GPX3 ITGB4 EDNRB PDGFC COL13A1 KCNJ8 CXCL12 COMP HLA-DMB MME MYLK PMC3078731__F3 Central prostate cancer-related processes and their miRNA-mediated regulation MDM2 RHO PTEN PMC6835793__F1 The CD40-ATP-P2X7pathway links cellular responses in Müller cells with the induction of inflammatory responses in bystander microglia/macrophages in DR CD40 CCL2 NOS2 IL1B PMC8300779__F2 Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs KEAP1 RBX1 PMC5542024__F9 Graphical Summary ARHGEF1 CSK ARHA PMC2259254__F2 Balance between muscle hypertrophy and atrophy depends on whether protein synthesis is more active than degradation or vice versa IGF1 GSK3B MTOR PMC8766493__F7 Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy PC FFAR1 TG PMC6966572__F2 PARP inhibitors in combination with other therapeutics TBK1 CXCL10 APC CCR7 CXCL9 IRF3 PMC12162639__F1 NLRP3 inflammasome signaling pathway NLRP3 MYD88 GSDMD PMC7594482__F1 Osteogenesis regulating signaling pathways RUNX2 SMAD2 SMAD4 PTH RYK RHO FOXO1 FGFR2 SOX4 CBL FGFR1 HEL-S-11 SUFU GRB2 SMO ROR2 FRAT1 PMC6720185__F1 Stress and depression drive an increase in corticotropin releasing factor (CRF) that activates mucosal mast cells and leads to an increase in gut permeability, coupled to gut dysbiosis and decreased butyrate production ASMT P2RY1 AHR CYP1B1 CYP2C19 TES BDNF AANAT PMC2858440__F5 Four flux sensors of the in silico cell PTS FAP CRP CRAT PMC12162639__F2 Inflammatory regulation in the process of venous thrombosis formation VCAM1 VWF TF PMC5945810__F2 Protein regulation of the TLR2/1 signaling pathway TRIM13 CYLD IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 IL1B SOCS1 TIRAP PMC7140927__F1 Sensing mechanisms for abiotic stress in plants ICE1 EGR2 SOS2 ERF SOS1 PMC7080653__F1 T1DM candidate genes acting at the beta-cell level mainly play a role in three pathways (): (1) Regulate the innate immune response and pathways important for antiviral activity, such as the type 1 IFN signaling pathway (IFIH1, TYK2, PTPN2) STAT1 CLEC16A BACH2 STX4A IRF9 ERBB3 TYK2 CTSH JAK1 GLIS3 TNFAIP3 PMC7848346__F1 Traditional (right hand side, orange background) and alternative (left hand side, blue background) renin‐angiotensin‐aldosterone system pathway DAP ACE2 PMC3245020__F3 Disease/drug mapping is the process to map all known disease genes (pink) and all known drug targets (light blue) against all KEGG pathway maps CASP3 SNCA BAD GSK3B LPL APP TNF FADD APOE PMC7048131__F3 Advances of the STAT3 signaling pathways involving breast cancer proliferation and apoptosis EGF TRIM14 TFEB SMYD2 DPF3 EGFR CCL18 WWOX STAT3 BAX PMC8282123__F1 Endocrine Influence on Cardiac Metabolism in Development and Regeneration GC HEL-S-5 PMC7048131__F2 Advances of the STAT3 signaling pathways involved in breast cancer progression EGF COX2 SMYD2 EGFR OSM STAT3 PMC4264574__F1 TLR4 signaling cascade CD14 HMGB1 IL16 TLR4 IRF7 IRF3 MYD88 TIRAP PMC3012138__F3 A network of hits highly enriched in cell cycle-related genes APOA4 EEF2K GNRHR APC PTK7 DGKB RPL31 TRPC4 MYLK2 HNF4A FRK PKIB PEX26 RAN ATR PMC7048131__F5 Advances of the STAT3 signaling pathways involving breast cancer chemoresistance LIF STAT3 PMC7048131__F4 Advances of the STAT3 signaling pathways involving breast cancer metastasis PIM1 VASP TFEB MMP2 MMP9 ARHGAP24 OSM RHOU WWOX STAT3 PMC7048131__F1 Classical IL-6/STAT3 signaling pathway in cancer cells EGF EGFR STAT3 PMC5945810__F1 TLR2/1 signaling cascade and respective regulatory nodes IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 IL1B TIRAP PMC9582503__F1 MicroRNA and Their Potential Role in Conjunctival Disorders DGCR8 DROSHA RAN PMC3165102__F1 TGFB/SMAD/GLI2 signaling axis in cancer progression and metastasis SUFU SMAD4 CCND1 SMO PTHLH PMC2634812__F5 Schematic of counterbalancing and dose-dependent regulatory forces that act on T-cell precursors through the ETP and DN2 stages GIG8 SPIB PAX5 NOTCH1 GATA3 PMC2634812__F4 Myeloid diversion pathways for advanced pro-T cells by re-introduction of C/EBPA or PU.1 MYB GIG8 MPO EGR2 ATL1-beta LCK NOTCH1 BCL2 ETS2 GATA3 PMC8307416__F5 Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells PML SOX2 FOXM1 RUNX2 SMAD2 KLF5 SMAD4 PAX3 ID3 EDNRA GIG8 TBX5 CCND1 SMAD1 GATA3 TRIR PMC2634812__F3 Stepwise respecification of ETP and DN2 cells by GATA-3 overexpression CPA3 GATA3 THY1 GATA2 PMC8584434__F4 Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications HEL-S-62p TFPI ACE2 TF PMC5697340__F1 Stages of innate lymphoid cell (ILC) development GIG8 ZBTB16 NFIL3 IL2RA TOX CXCR6 GATA3 PMC11203986__F7 HIRA-associated pathway HIRA MYC KPNA2 PMC11203986__F6 CAF-1-associated pathway HIRA ASF1A HDAC1 PCNA PMC4058004__F1 Simplified biotransformation scheme of tamoxifen in man. Tamoxifen is mainly N-demethylated to NDM-TAM and subsequently 4-hydroxylated to endoxifen UGT1A4 CYP2C9 CYP3A4 PMC11203986__F8 NAP1L1-associated pathway CCND1 CDK4 CDK6 PMC8817856__F8 ROS/GRK2/HIF-1A/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin HP ADRBK1 GSDMD PMC9274484__F4 Gut microbiome in gastrointestinal cancer: a friend or foe? TLR4 TIGIT MYD88 COIL TNF PMC6135677__F7 Sketch diagram illustrated the target genes by the selected miRNAs in ROS-AKT-cyclinsenescence pathway CDK2 GSK3B CDK4 CCND2 AKT3 PMC9274484__F3 Gut microbiome in gastrointestinal cancer: a friend or foe? COX2 CXCL16 LTA TLR4 MYD88 CXCR6 PMC2077853__F9 Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation RET LYN GDNF SRC PMC4153443__F1 The mammalian circadian clock FBXL3 RORA PMC9274484__F2 Gut microbiome in gastrointestinal cancer: a friend or foe? NOD1 PTEN AXIN2 MTOR BRCA1 PMC9277653__F4 Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment EGF ERG EGFR MTOR TF PMC8955937__F11 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders HIF1A HEL-S-133P HK2 WWOX PMC4499569__F2 Neuroprotective cross-talk involving the cytoprotective PI3K/AKT pathway PINK1 IGF1 IRS1 PMC5840486__F1 Schematic illustration of the main hedgehog (Hh) pathway components SUFU PTCH1 GLI3 SHH SMO SNAI3 PMC3312480__F1 Schematic view of potential targets and site of action of some biologics in IBD TH APC SMAD4 PMC8168453__F2 Schematics of the TIM3/Gal9 signaling pathway in T cells FYN CSK LCK ZAP70 HEL-S-92n LAT IFNG PMC8168453__F4 Schematics of the TIM3/Gal9 pathway in innate immune cells TLR4 APC IFNG PMC9409562__F1 Type I interferons during host–fungus interactions: Is antifungal immunity going viral? SP110 PDC STAT2 TYK2 TLR3 PSMB8 MAVS PMC8955937__F10 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders CS HIF1A HEL-S-133P HK2 WWOX PMC10180405__F3 BMP-2 and Wnt/Beta-catenin signaling pathways participate in the pharmacological activity of naringin in mediating osteogenic differentiation RUNX2 APC LRP5 SMAD4 LRP6 AXIN2 DKFZp781O1323 TCF4 PMC12123823__F1 Mechanisms underlying NET formation MPO RIPK3 CDK4 CDK6 MLKL GSDMD PMC7697962__F2 Top two networks constructed by ingenuity pathway analysis (IPA) showing interactions between the top 100 differentially expressed genes (DEGs) in the dendritic cells (DCs) from patients with allergies MMP14 MAPK13 EHD1 ERG PROC CREM ZNF180 PMC10525949__F6A Transcriptomics Reveal the Effects of Breeding Temperature on Growth and Metabolism in the Early Developmental Stage of Platax teira UBC PLTP UCP1 HEL-S-28 LPL SHE CPT2 PMC8222468__F2 Extracellular vesicles in podocyte autophagy in kidney disease TSC2 PML EEF2K TSC1 EEF2 PTEN BNIP3 MTOR ATG14 RHEB MLST8 PMC3117856__F3 MAPK signaling pathway EGF c-fgr NGF MAX FLNA FOS GCK ECSIT CRKL PMC2994991__F6 Reporter gene assay for HIF-1 activity HIF1A PMC4946894__F1 Apoptosis pathways in various organisms SKI TNF BAX PMC8616058__F1 Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics TH RAB35 PLD2 UBB PMC6314011__F3 The interplay between intrinsic (i.e., circadian clock) and neurohumoral factors in circadian control of both metabolism and redox tone PIK3R1 DGAT2 HK2 PMC2832945__F7 Proposed mechanism for B2M mAb inhibition of AR and cell proliferation, survival, and progression through a MAPK/SREBP-1 signaling pathway in prostate cancer cells B2M PMC5088563__F1 Signaling cascades implicated in developmental cell death and tissue homeostasis RIPK1 GPX4 TLR4 RIPK3 BCL2 TLR3 STAT3 PMC6390240__F4 Modules of core PPI networks of baicalein against HCC TUBB HSP90AB1 NTRK1 EGFR EEF1A1 CAND1 FUS BRCA1 YWHAQ ERBB2 CDK2 MDM2 CDC2 TRIM28 HSPA1A PMC5168844__F1 Network structure for RAS signaling pathway in Head and Neck Squamous Cell Carcinoma (HNSC) PRKCA KIT MAPK9 BAD GAB2 NFKB1 EGFR MAPK1 RAF1 PMC6964830__F8 Functional network of proteins in stage 3 breast cancer samples Meflin WWC1 MOB1A FKBP9 PMC8757397__F1 Pathophysiology of COVID-19-associated coagulopathy TFPI PLG CRP IL6 CCL2 TNF ACE2 IL1B TF PMC2909654__F5 Examples of human disease phenotype correlations in the absence of metabolite sharing but detected by flux correlations FECH UROD UROS OTC ASL PMC3820238__F1 Schematic overview of TGFB signaling LIMK1 NODAL SMAD2 SMAD6 RHO TF PMC4836751__F5 Transcriptional Profiling of Ileocecal Valve of Holstein Dairy Cows Infected with Mycobacterium avium subsp. Paratuberculosis CD37 CD33 FOS LCK ZAP70 GRB2 JUN CBLC LAT ICOS PMC8362800__F2 SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors SUFU PTCH1 SHH SMO SPOP PMC6557983__F1 Pathogenesis of hRSV and molecules with a biomarker potential induced in the airways during hRSV infection TH CXCR1 TLR4 IL33 IL8RB MYD88 TSLP TLR3 PMC2837270__F8 Seoul virus suppresses NFKB-mediated inflammatory responses of antigen presenting cells from Norway rats IL10 IKBKE IFNA1 CSF3 IRAK2 CCL2 MYD88 TLR1 TNFSF6 TNFRSF1B LTA NFKB2 TNFSF10 CD40 IRF-1 CASP8 PMC8395571__F7 Pathway-targets analysis CCNA2 KDR RUNX1T1 BIRC5 CCNB1 CDC2 TOP2A CHEK1 BAX PMC3370249__F7 Proposed FasL-Met signaling pathway TH CCND1 STAT3 PMC7774657__F1 Aspirin’s role in colorectal cancer prevention Cyclooxygenase (COX) dependent pathway (Left panel): Inhibition of COX-1 in platelets and COX-2 in epithelial cells CXCL1 COX1 TNF PMC6468861__F2 miRNA biogenesis pathway and various single nucleotide polymorphisms (SNPs) occurring at different steps of the pathway that play a pivotal role in prediction of breast cancer risk development AGO2 DGCR8 DROSHA PMC9288680__F10 Macrophage-derived apoptotic vesicles regulate fate commitment of mesenchymal stem cells via miR155 RUNX2 SMAD2 BGLAP PMC10757365__F3 Immune checkpoints in antitumor response: a potential antitumor immunotherapy STAT1 APC CD80 JAK1 IRF-1 PMC10376142__F1 Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms FURIN ANTXR1 PMC3346695__F2 Cell signaling pathways involved in ischemic postconditioning BAD GSK3B PTEN BAX PMC9029764__F2 Dangerous Liaisons in the Oxidative Stress Response to Leishmania Infection CXCL10 CCL5 IL6 TLR3 PMC6148086__F8 Schematic summary MTOR TGFB1 PMC6964830__F5 Functional network of proteins in stage 2 breast cancer samples, (confidence level = 0.150) Meflin MOB1A FKBP9 PMC4193347__F6 Germline PTEN Mutation Cowden Syndrome: An Under-Appreciated Form of Hereditary Kidney Cancer SDHC FLCN HGF VHL PTEN RHEB TSC2 TSC1 TFEB FH FNIP2 FNIP1 SDHD SDHB PMC7464713__F7 Implemented model of the Wnt-independent Beta-catenin pathway SOX17 TCF4 PMC8196972__F6 Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis CCR2 CD34 CCL2 PMC3817731__F3 Activation of the EGFR pathway and the consequent engagement of the Ras/Raf/MAPK and PI3K/Akt pathways EGF EGFR GRB2 PMC2987484__F1 Pathway analysis on differentially expressed genes PDE1B EFNA1 BACE2 S100A2 PCDH7 NEFH SLIT2 DRD2 USP24 MPHOSPH6 GPX7 TACSTD2 RAB15 FYN SMARCA4 RPL21 opn PTP4A2 APP HEL-117 GPR3 PTPN5 LOC51064 LIMK1 SST SPRY4 TNF CCKBR CDC42EP4 CHRM3 HEL-S-75p PCSK1 HTR2A THOP1 STK32C MME PMC8517841__F6 Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway SLFN11 TYK2 JAK1 PMC2435243__F9 Several signaling pathways work together in the TGFB1-induced expression of CCN2/CTGF in primary human gingival fibroblasts HEL-S-62p RHO LPA CDC42 PMC3858190__F4 Pathways involved in sensing and responding to double-stranded RNA and other pathogen-associated molecular patterns were suppressed by SMD LTA CD40 IL4 JUN FADD MAVS PMC7563728__F1 Metabolic pathways and Snail target enzymes of catabolic metabolism TIGAR FBP2 F2 FBP1 HEL107 PMC3858190__F9 Ingenuity pathway analysis of differences between LPS and LPS + SMD (300mg/kg) with regard to reproductive hormones YTHDF2 ATAD3A CEP170 MYO1C GRWD1 GEM UCK2 GAS7 WDR26 PHF5A UGDH ACAP1 PPIF GJA1 MRPS6 GRB2 PFKFB2 CYFIP2 DHRS3 HK2 TCEAL8 ST6GAL1 PMC10987845__F1 Glycan biosynthesis mutants were screened for immune stimulatory properties CD80 GAL PMC3169412__F1 Fatty-acid biosynthetic pathway for R FBL FOS FES FASN PMC6771463__F6 Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma GRPR PTEN MTOR PMC6119869__F3 The paradoxical HH pathway SUFU SHH PMC6119869__F2 The HH signalling pathway SUFU PTCH1 SMO PMC6982256__F5 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents ULK1 TSC1 RHEB PMC8275186__F1 Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA GIG8 FANCD2 FANCM RAD18 PCNA PMC3397315__F4 Summary of ion channel targets of the GSK-3 pathway KCNQ2 PMC9048451__F2 Abnormal synaptic plasticity and impaired cognition in schizophrenia TH DDC HTR4 GLS PMC5999603__F8 The model of linc00462 regulation in PC SMAD2 TGFBR1 TGFBR2 OSM PMC8883537__F5 Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma PTPRC JAK3 COIL TG STAT5B SOCS1 STAT3 SH2B3 PMC6813250__F3 JA-mediated cold and freezing stress responses in plants ICE1 ICE2 PMC5666906__F6 The impact of EGFR-ERK pathway on the type I interferon response in human keratinocytes STAT1 IFIT2 IFNK EGFR CCL2 IRF-1 IFIT1 PMC8573303__F3 Effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection CD40 CD80 CCL22 CYP27B1 PMC5328970__F3 Sema3A signaling in bone remodeling SEMA3A NRP1 FARP2 ARHA PLCG2 PMC6119869__F4 Mechanisms of resistance to SMO inhibitors SUFU PTCH1 SMO PMC6385204__F7 Angiomotin-p130 inhibits Beta-catenin stability by competing with Axin for binding to tankyrase in breast cancer APC GSK3B TNKS PMC4538064__F3 Insights into the molecular mechanisms of methylmalonic acidemia using microarray technology CASP3 NF1 CD14 MOS MAX ATM FLNA GCK KEL TNF TRAF2 PMC3870411__F1 TNF Signals through TNFR1 and TNFR2 receptors (A) but abnormalities in this signaling pathway in autoimmunity (B) can favor a pathway of selective apoptosis due to a variety of protein signaling defects TRADD TNF TRAF2 FADD PMC3273665__F2 SREBPs in the innate immune response NLRP3 TLR4 TLR9 IFNAR2 MYD88 IFNAR1 IL1B TLR3 PMC9599708__F3 Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis ULK1 BAD MDM2 ATG101 ULK2 PMC7053069__F7 Schematic of CPT’s anti-inflammatory mechanism in LPS-stimulated RAW264.7 cells TLR4 KEAP1 MYD88 PMC5680590__F7 CAV1 orchestrates the TGFB response in HCC EGFR NOX4 BMF PMC9162579__F4 Genome-Wide Mutant Screening in Yeast Reveals that the Cell Wall is a First Shield to Discriminate Light From Heavy Lanthanides ALG3 ALG6 PMC5875422__F8 Schematic shows the relationship between neuronal and oligodendrocyte metabolism NAT8L SGMS1 UGT8 ASPA OLIG2 PMC6103739__F7 Schematic diagrams of SOS1 activation EGFR GRB2 GIP PMC4344206__F1 Platelet signaling pathways COX1 GC SYK ORAI1 STIM1 PMC9531149__F3 Role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy RPE PMC9201572__F15 Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGFB/Smads Signal Transduction SMAD2 SMURF2 SMAD4 HEL113 SKI SMURF1 PMC3666437__F5 Regulation of upregulated miRNAs on the downregulated mRNAs in antigen processing and presentation pathway and p53 signaling pathway HEL-S-99n MYC PIGS TNF MTOR CDK6 IFNG CANX PERP BCR REST CDK4 B2M ATR PMC10542959__F4 FOXM1 may be involved in diabetic nephropathy by regulating signaling pathways such as NFKB/NLRP3 and Wnt/Beta-catenin NLRP3 SIRT4 FOXM1 CCND1 PMC3717793__F1 Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 TOB1 SKP1 RBX1 FOXO1 SKP2 PMC10542959__F3 FOXM1 is involved in regulation of diabetes-related inflammatory responses FOXM1 CX3CL1 TNF MTOR IFNG PMC11927582__F3 Sufu plays an important regulatory role in Toll-like receptor (TLR)-mediated inflammatory responses NLRP3 IRAK1 SUFU TRAF6 IRAK4 MYD88 PMC11927582__F2 LAT in the TCR pathway enhances signal transduction by sequestering inhibitory factors through a LLPS mechanism FOS GRB2 LAT PMC8350386__F1 MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body BAMBI SMAD2 TGFBR1 SMAD6 SMAD4 TRAF6 TRAF4 PMC6766659__F6 Pathways that mediate the effects of NANOG on COL3 expression by senescent cells COL3A1 SMAD2 SMAD6 SMAD4 PMC9199556__F6 Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States MPO TRPV2 PMC8534183__F5 New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NFKB Signaling-Mediated Inflammatory Responses in Human Monocytes ABCB6 FECH TLR4 STEAP3 ABCB10 TNF PMC5868815__F4 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases EGF BAD BRAF TGFBR2 SMAD4 PTEN RB1 MTOR E2F3 MSH6 MDM2 CASP9 CCND1 MAPK1 SRD5A2 AXIN2 JUN FOS APC RAC1 HEL-S-22 HEL-S-125m IKBKB CASP3 LEF1 CREBBP MAP2K1 CDKN1A NFKB1 CDK2 GRB2 PIK3CA BCL2 SOS1 CYCS AKT3 PMC5868815__F3 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases EREG EGF NRG3 BAD BRAF NCK2 MAP2K4 GSK3B MYC MTOR PI3 BTC SRC JUN ABL2 MAPK10 NRG2 NRG1 CRK CBL PRKCB CDKN1A GRB2 PIK3CA SHC4 SOS1 NRG4 PMC9029562__F4 Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase DBH TYRP1 PMC3107200__F8 Chk2 and p53 Are Haploinsufficient with Dependent and Independent Functions to Eliminate Cells after Telomere Loss ATM SKI ATR PMC5383719__F3 Low-avidity signaling of B2-integrin regulates toll-like receptors (TLR) signaling in macrophages TLR4 SRC SYK MYD88 CD2AP PMC2852602__F2 TLR/IL-1R signalling pathways TLR5 TLR7 TLR4 TLR9 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TIRAP CD36 PMC6274341__F1 Isoprenoid biosynthetic MVA pathway in the plant cell MVK IPP MVP PMC9639265__F1 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 XBP1 PMC4209143__F2 Macroautophagy is regulated by several signalling pathways CALCA HEL-S-11 INS CAD DEPTOR RHEB MLST8 PMC9639265__F3 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 MTOR XBP1 PMC9639265__F2 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 TNF XBP1 STAT3 PMC9046545__F4 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review FGFR1 FGFR3 FGFR4 FGFR2 PMC9046545__F3 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review FRS2 GRB2 CBL PMC9639265__F4 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 MYC HIF1A XBP1 PMC9240045__F7 Schematic time-course changes in cellular processes in phosphorylase liver isoform knockdown (shPYGL) and control (shControl) U87MG glioblastoma (GBM) cells following high dose ionising radiation (IR) GYS1 PYGB GAA PYGM PYGL PMC9537356__F5 On-Target Side Effects of Targeted Therapeutics of Cancer CSK NRG1 MTOR PMC5746461__F5 Serotonin neuron development: shaping molecular and structural identities SLC17A8 HTR1B TPH2 MAOA SLC22A3 LPAR1 LMX1B GATA2 ADRA1B DDC SLC18A2 HTR1A INSM1 GRIA4 HCRTR1 EN1 GATA3 PMC4322535__F3 Signalling pathway of renal tumour-propagating cell membrane markers and “cancer stem cell” markers CXCR4 CD44 HDAC5 SMAD1 DKFZp781O1323 PMC4209143__F3 Macroautophagy in the immune system TLR9 BCR PMC2672206__F7 Regulation of osteogenic differentiation of MC3T3-E1 cells by substrate rigidity HEL-S-62p RUNX2 ARHA PMC8651982__F5 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development LEF1 HIPK2 UBR5 EGFR PMC9372833__F5 Occurrence of MYD88L265P and CD79B mutations in diffuse large b cell lymphoma with bone marrow infiltration: A case report IRAK1 TRAF6 IRAK4 MYD88 MTOR CD79B TG CD79A BTK CARD11 BCL10 LYN LPL SYK PMC8836162__F4 EphrinB2–EphB4 Signaling in Neurooncological Disease DLL4 EGFR VEGFA PMC8836162__F2 EphrinB2–EphB4 Signaling in Neurooncological Disease SOX1 RRAS ARHA HRAS PMC8195694__F1 Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies TLR7 ACE2 TLR3 MAVS TMPRSS2 PMC11039848__F2 How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography? CYP27A1 CYP8B1 CYP7B1 BAAT CYP7A1 PMC4624093__F1 Biomarkers of Angiogenesis in Colorectal Cancer PIGF VEGFC VEGFA SRC VEGFB PMC5705427__F3 Psoriasis: A mixed autoimmune and autoinflammatory disease CXCL1 ERAP1 CXCL2 CARD14 PMC4437805__F1 Wnt signaling pathways NOTUM GSK3B LRP5 LRP6 ARHA RYK RAC1 PMC9413544__F1 Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan KMO ACD AANAT PMC10648403__F6 Expression profiles of genes involved in the phenylpropanoid biosynthesis pathway CPA3 CAD CPA1 PMC8910922__F1 Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases KEAP1 CDK5 CYS1 TG PMC3066660__F6 Significantly expressed genes in cytokine–cytokine receptor interaction pathway disturbed by SM at different time points EPOR SST EPO HGF TPO TNF TNLG7C CCL1 PRL EDAR LEP AMH NGFR CCL17 KITLG FLT3 OSM MPL LTBR ACR PMC5094708__F6 Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication FASN PMC5132145__F4 Phagocytosis of apoptotic corpses ARHG EPN1 APC FERMT2 MTM1 CDC42 TRIO PMC5850397__F1 Mechanism of apoptosis induction by Vesicular stomatitis virus (VSV) in the infected cell RAE1 NUP98 PMC4703580__F1 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases TRAF6 ATF3 MYD88 FOXO1 SOCS1 TIRAP PMC3888942__F6 Axon navigation pathway targeting by miRNAs that differentially associate with Ago2 in an activity-dependent manner ROCK2 LIMK2 L1CAM SEMA7A CDK5 FES ARHA ROBO2 RHO RAC1 SLIT2 EPHB1 ROBO3 FYN CXCR4 PLXNA2 ROBO1 RND1 EPHB2 PLXNB2 PMC5951297__F4 Identified pathway between EGFR and JUN for Loi’s breast cancer dataset SMAD2 LCK EGFR SMAD4 MAPK1 NCOA1 JUN CCNE1 PMC2645904__F3 Schematic representations of potential signaling pathways involved in serum-deprived retinal ganglion cell-5 cells EGF PPARGC1A FOS ALB UXS1 NR1C1 DNASE1 ACADM RXRA IFNG TEAD2 PMC3116645__F1 Mammalian target of rapamycin (mTOR) signaling pathway RICTOR IGF1 EIF4E MTOR IRS1 RHEB MLST8 PMC6349890__F7 Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factorB and NLRP3 inflammasome signaling pathway NLRP3 TEC PMC6933909__F8 Schematic representation of the working model NOTCH2 E2F8 PTEN MTOR PMC2779188__F1 Genes involved in the vitamin D pathway IL10 CYP27A1 VIT NR1i1 CYP2R1 GC IL1RL1 CYP24A1 PMC8895170__F3 Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease ANGPTL3 LPL GPIHBP1 TG PMC5168844__F2 Network structure for PI3K signaling pathway in Lung Adenocarcinoma (LUAD) TSC2 PRKCA HEL2 NFKB1 CDKN1B MYC CASP9 MAPK1 BCL2L11 CCNE2 PMC5216781__F4 Overexpression of TELO2 decreases survival in human high-grade gliomas TTI1 ATM RUVBL1 EGFR PIK3CA MTOR ATR PMC5241525__F1 Several signalling pathways can induce epithelial-mesenchymal transition in pancreatic cancer cells for example Notch, transforming growth factorB, Midkine, hypoxia-inducible factor-1A and tumor necrosis factorA HIF1A TGFB1 PMC3084000__F1 Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003) HHIP PTCH2 FOXM1 DISP1 SUFU DISP2 PTCH1 GLI3 SMO CCND2 PMC5009320__F5 3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model PIGS PTEN MTOR RFWD2 TSC2 CASP3 SIAH1 PERP CDK2 MDM2 CASP9 CASP8 BAX PMC3021097__F2 Functional significance of itpkc_3 on ITPKC mRNA and Ca2+/NFAT pathway ITPKC HEL-S-11 APC GC PMC4703580__F5 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases SYK MYD88 TNF PMC3919687__F6 Kinetic changes in gene expression of selected components of Th2 responses MAF TYK2 JAK3 SOCS1 STAT3 GATA1 PMC3919687__F5 Kinetic changes in gene expression of selected components of the Wnt/Beta-catenin signaling pathway in aging CD8+ T cells LEF1 APC GSK3B LRP5 LRP6 SMO WNT10A PMC5417249__F1 Shared coregulator GRIP1 in the GR and type I IFN signaling networks TLR4 GRIP1 IRF7 IRF9 IRF3 TYK2 IFNAR2 MYD88 JAK1 IFNAR1 TLR3 PMC4136196__F5 Coinfection of Filifactor alocis with P PTMS PABPC1 PPIB AHNAK PMC9501144__F5 Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia NRF1 BDNF SIRT1 BAX PMC8181394__F3 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy SQLE HEL-S-11 LDLR PPAN HMGCR PMC8181394__F2 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy SQLE ACAT1 HMGCR PMC6598098__F6 Putative C4pathway in Alloteropsis semialata PC MAL PMC4208677__F4 Ingenuity canonical pathway analysis CCR5 SOCS3 PLK1 FANCD2 BLM ATF1 TRAF6 BACH1 CCR1 IFNG STAT1 ATM ARG2 RAD51 MSH2 SP1 BARD1 TNF MRE11A BRCA1 BRCA2 LBP TYK2 JAK1 FANCA ATR FANCE FANCG STAT3 PMC2678071__F1 Graphical representation of the gp130/JAK/STAT pathway SOCS3 LIF OSM PMC12144116__F0 GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy RAC1 SP1 AXL STAT3 PMC8855423__F6 Lovastatin Inhibits RhoA to Suppress Canonical Wnt/Beta-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer GSK3B ARHA PMC3245506__F4 Network of differentially expressed genes in HMGA1 transgenics at 12 months (nonparametric approach) IL10 TFPI EBI3 CD5 HLA-DOB CD200 HCTP4 KPNA1 ST8SIA1 GAD1 HMGA1 YWHAQ HMMR PDE4B KPNA3 ST18 IL18R1 MUXA PMC10380785__F3 Lignin, the Lignification Process, and Advanced, Lignin-Based Materials STS CAD PMC3245506__F3 Network of differentially expressed genes in transgenics at 2 months (parametric and nonparametric approaches) PSEN2 FCRLA ATF2 CD44 DIRAS3 HMGCR NCR1 HMGA1 CXCR3 LTA MAX MTSS1 GHR APP GZMM IL2RA CD80 B2M PRKCH TRAF2 IRF-1 IL18R1 PMC3245506__F2 Network of differentially expressed genes in HMGA1 transgenics at 2 months (parametric approach) PSEN2 FGF13 ID3 NCR1 HMGA1 LTA INSIG1 APP UNK PRF1 IL2RA CD80 PRKCH IRF-1 KRT10 PMC3245506__F1 Network of differentially expressed genes in HMGA1 transgenics at 2 months (nonparametric CAM approach) MPO CD244 RB1 ST8SIA1 NCR1 HMGA1 BCL6 CTSG PRTN3 HEL57 GZMA ELANE PRKCH CST7 CDC73 PMC3245506__F6 Network of differentially expressed genes in transgenics at 12 months (parametric and nonparametric approaches) RAPGEF1 CCNA2 MYBL2 APC S1PR3 TFRC HCTP4 ST8SIA1 CDKN2A HMGA1 DKFZp761E1322 VAV3 HMMR FCER2 RRM2 CD2 CCNG1 APP LPP KPNA3 CR2 CCNE2 PMC3245506__F5 Network of differentially expressed genes in HMGA1 transgenics at 12 months (parametric approach) UBE3A LIMK2 DKFZp781B1423 IRAK1 EEF1E1 CCNG2 SPAG5 HMGA1 FEN1 PAK1 UBQLN1 PRP4K HEL164 CCNG1 NEK2 SMG1 MSH3 PER3 PMC7842749__F8 Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease HEL70 HTT AQP4 PMC11561128__F8 GLS2-mediated glutaminolysis accelerated AS process by encouraging endothelial mitochondrial dysfunction and pyroptosis via SIRT3/FOXO3a axis NLRP3 GLS2 GSDMD SIRT3 PMC9553361__F2 Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy ATP7A GC DLAT PMC5356597__F3 GADD45B, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens CD14 E2F4 CDK2 MDM2 STAG1 DBF4 RAD21 CDK7 CDC45 PCNA SKP2 MYT1 PMC2923430__F9 Immune Response HEL-S-62p C9 MASP1 C7 C6 PMC4758681__F6 The mechanism of Wnt-mediated suppression of osteoclast differentiation NFATC1 APC LRP5 LRP6 PMC7367812__F2 Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions TBK1 TRADD STAT2 IRF7 IRF9 CXCL10 IFITM2 TRAF3 TRAF6 IRF3 MYD88 CASP10 TRIM25 TLR3 ISG15 CASP3 TLR8 TLR7 ISG20 IFNK ECSIT TRAF2 ACE2 TMPRSS2 PMC3226315__F1 Recent focus in JMML has concentrated on using the information gained from knowledge of these molecular defects in order to design targeted drug therapy NF1 GRB2 PMC5727313__F1 The B‐catenin‐dependent Wnt signalling cascade in the ON‐state PCK1 APC LRP5 LRP6 PAF1 PMC7022273__F2 : Ca2+-calpain, cAMP- exchange protein directly activated by cAMP (Epac)- phosphoinositide-specific phospholipase CE (PLCE)-inositol phosphate 3 (IP3), and inositol signaling pathways of autophagy regulation HMGB1 RAP2B TFEB ATG12 FOXO3A FOS BNIP3 ATG14 JUN DKFZp686F0183 FOXO1 PMC8551632__F5 Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and Disease RELA VEGFA PMC7022273__F3 Binding of tumor necrosis factor A (TNFA) with TNF receptor activates the receptor, which recruits TNFR1-associated death domain protein (TRADD) RIPK1 ATG3 TRADD CYLD RIPK3 TRAF2 FADD MLKL PMC479700__F1 IFN-Gamma-inducible CIITA transcription from the type IV promoter is mediated by the Janus Kinase-1/Signal Transducers and Activators of Transcription-1 (JAK-1/STAT-1) signaling pathway STAT1 MHC2TA USF1 PMC7616045__F1 Serine synthesis pathway, folate cycle and methionine cycle PSAT1 DHFR PSPH PHGDH PMC7080263__F5 RNA-seq transcriptomic analysis reveals genes mediating salt tolerance through rapid triggering of ion transporters in a mutant barley SOS2 ERF PMC8651982__F1 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development BARHL2 APC GSK3B LRP5 LRP6 HDAC1 PMC7864737__F4 Target genes in the mTOR signaling pathway FLCN PTEN EIF4E MTOR DEPTOR RHEB PMC3654985__F4 Peritumoral (P) activated hepatic stellate cells (HSCs) and intratumoral myofibroblasts (T) UBC PLTP PERP ATM SRA1 LPL CPT2 PTEN PMC7998496__F1 Mode of curcumin actions as anti-cancer agent on the key molecular targets in GBM MDM2 SHH SMO BAX PMC1774677__F1 Diagrammatic indication of the cytokines, transcription factors, and signalling molecules which polarise virgin CD4 cells into T helper cell type I cells STAT1 STAT4 STAT3 PMC8745665__F2 Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration BAD M6PR IGF2 GSK3B IRS1 FOXO1 IGF2R INSR PMC4449428__F1 TGFB signaling in gliomagenesis and its targeting SOX2 CYLD LIF TGFBR1 IGFBP7 SMAD4 PTEN ID1 ID3 SOX4 PMC5356913__F2 Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation BTK SYK RHO PMC2994209__F1 HER receptors and their ligands EREG NRG3 EGF AREG EGFR NRG2 HBEGF NRG1 NRG4 TGFA PMC2923187__F8 Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction E2F4 HEL-S-28 EGFR INS E2F5 ATP6V0D1 CCL5 TNF STK24 RANBP2 PDPK1 IFNG PMS2 ELAVL1 IGF1 PKLR APP ANP32B SMPD1 IL1B PMC5587989__F2 YAP is regulated by various factors during hepatocarcinogenesis in addition to the members of the Hippo signaling pathway MCAM BTRC MAPK14 TRIB2 PMC5587989__F1 Hippo/YAP signaling pathway maintains the balance between cell proliferation and apoptosis LATS1 LATS2 PMC8844466__F6 In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems TH TRAF3 IRF3 TLR3 PMC8957335__F2 Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma SUFU GLI3 SMO PMC5393956__F2 mTORC1 and mTORC2 in cancer and the tumor microenvironment TSC2 TSC1 PTEN RHEB PMC8699317__F5 CD44: A Multifunctional Mediator of Cancer Progression TWIST1 CD44 RAB7A HAS2 FGFR2 PMC3358519__F1 Schematic diagram of the cholinergic anti-inflammatory pathway (CAP) ACHE STAT3 PMC3924851__F2 New Function of Type I IFN: Induction of Autophagy ATG16L1 ATG12 ATG3 STAT2 IRF9 IFNAR2 EIF4E ATG10 IFNAR1 IRS1 STAT1 IFNK JAK1 RPS6 EIF4B PMC6977532__F2 Sepsis on AHR and inflammatory factors TLR4 AHR SRC IL1B STAT3 PMC3268941__F1 Canonical Wnt/Beta-catenin and non-canonical Wnt signaling pathways ROCK2 LRP5 LRP6 ARHA ROR2 RAC1 PMC5148031__F5 Developmental Stage, Muscle and Genetic Type Modify Muscle Transcriptome in Pigs: Effects on Gene Expression and Regulatory Factors Involved in Growth and Metabolism CTBP2 RBP1 NFATC4 PLIN1 SETDB1 BMP2 CTBP1 HIF1A FOXC2 HEL-S-104 XBP1 FBXW7 KLF3 DKFZp686F0183 SOX9 LEP MNAT1 EGR2 LPIN1 BSCL2 MSC LPL TXNIP PMC5464927__F4 Regulation of Beta-catenin activity and function in cancer: therapeutic opportunities LEF1 APC GSK3B LRP5 LRP6 TNK2 TNK1 AXIN2 BCL9 PMC2831839__F9 A proposed mechanism of MNTX synergistic effects with temsirolimus on inhibition of VEGF-induced angiogenic events RICTOR PI3 SRC MTOR PMC8044931__F2 Molecular mechanisms by which estrogens mediate chemoresistance ATM EGFR SSB BCL2 ATR BRCA1 PMC5090056__F1 Models of Hippo pathway in fly and mammals PATJ AMOT NF2 CRB3 LATS1 MOB1A MOBKL1A LATS2 PMC8702415__F3 Bioactive glasses incorporating less-common ions to improve biological and physical properties GSK3B PMC9094703__F1 Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders CRY1 HEL70 MAOA RORA NPAS2 PMC8234974__F3 Engineered EV-Mimetic Nanoparticles as Therapeutic Delivery Vehicles for High-Grade Serous Ovarian Cancer EGF SIRPA CD47 PMC7842075__F7 Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma CTRL MMP9 MTCH2 PMC9120866__F5 Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae SPSB2 ISG15 TRIM14 TRIM69 TRIM26 UBE2S PMC4160261__F1 Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease ULK1 LAMP2 MTOR PMC7232714__F8 DIFFERENTIAL ROLES AND ACTIVATION OF MAMMALIAN TARGET OF RAPAMYCIN COMPLEXES 1 AND 2 DURING CELL MIGRATION IN PROSTATE CANCER CELLS EGF RICTOR RAC1 PAH PMC8788756__F3 Physiology of Astroglial Excitability TRPC1 TRPV4 TRPA1 INSR PMC7911475__F2 Mechanism through which flavonoids induce cancer cell autophagy GC STAT3 PMC9303584__F2 Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics STAT1 NF1 BAD BRAF CDK2 EGFR MDM2 CDK4 PTEN CDK6 STAT3 PMC7158350__F9 Roles of DEAD/DEAH box helicases in innate immune signaling pathways TLR9 IRF7 TRIM21 DDX41 DHX36 IRF3 DHX15 MYD88 DDX24 TLR3 DDX46 BTK FADD MAVS PMC7042114__F1 BNP plays critical roles in itch transmission SST KPG_011 MMP9 CXCL10 NPPB S1PR1 HTR1F TRPV1 HRH1 HTR1A TRPM6 CCL20 ITCH PMC9154101__F7 HbF induction by SAL ATF4 ATF2 EIF2A CREB1 PMC5978700__F2 Role of RAS enzymes in the EGFR signaling pathway EGF EGFR TGFA PMC9415417__F2 Calcimimetics in Treating Bone and Mineral Disorders Related to Chronic Kidney Disease CASR NFATC1 MTOR WNT10B BAX PMC6162436__F1 Hippo pathway upstream modulation AJUBA TEAD4 LATS1 RASSF4 LATS2 TEAD2 TEAD3 RASSF1 NF2 RASSF2 WWC2 RASSF6 FRMD6 PMC6162436__F3 Repurposing of drugs on YAP (Yes-1 associated protein)-TEAD (transcriptional enhanced associate domain) system through cross-talking pathways AMOTL2 AMOTL1 GSK3B GRB2 AJUBA LATS1 RHO AXL LATS2 IRS1 PMC3496019__F1 Cancer Stem Cells DHH BOC IHH SUFU PTCH1 GLI3 KIF3A MYC SHH SMO PMC6981417__F7 Differential ganglioside metabolism pathways between MDA-MB-231 GD3S+ clone #4 and MDA-MB-231 breast cancer cells CAS1 SLC33A1 B4GALNT1 ST8SIA1 PMC6981417__F6 Differential ganglioside metabolism pathways between Hs 578T and MDA-MB-231 breast cancer cells CAS1 SLC33A1 B4GALNT1 ST8SIA1 PMC8304479__F6 Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145 NRAS MTOR SOCS1 STAT3 PMC8469825__F1 Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions ULK1 ATG12 STX17 MTOR DKFZp686F0183 VMP1 PMC3496019__F2 Regulation of CSCs by inflammatory cytokine networks CXCR1 RELA CCND1 IL8RB BMI1 PTEN STAT3 PMC8764452__F2 Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis CD9 MMP2 SHH CD81 PMC6626338__F7 LUCAT1 and Wnt/beta-catenin signaling in breast cancer APC LRP5 LRP6 TCF7L2 PMC8750814__F2 Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology TLR8 TLR7 CD27 GC CXCR5 CD40 IFNG BCL6 PMC2637783__F1 Toll-like receptor (TLR) signaling TBK1 TLR5 TLR9 IRAK1 IRF3 MYD88 TNF TLR1 TLR3 TLR8 TLR7 TLR4 MAL PMC8082422__F2 Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets FRS2 GSK3B GRB2 FGF19 FGFR4 PMC4987369__F1 Schematic representation of a mechanism of action for cannabinoid based multi-target drugs COX2 FAAH TRPV1 PMC11726942__S1 Amantadine and its therapeutic role in spinal cord injury CSF1R LY86 CX3CR1 CFH opn HEL-S-111 IL1B CD81 PMC3149084__F2 Single-run analysis of the yeast proteome by LC MS/MS HEL-S-26 PGM3 PGM2 FBP1 ACO2 ENO2 CIT HEL60 LAT HEL-S-32 PMC3527239__F2 Metabolic pathways of TAG synthesis and degradation and their subcellular localization (adapted from and ) FEN1 CDS1 GPT2 TES INS FAT1 HEL-S-5 PMC10519146__F10 Intracellular innate immune response to avian influenza TBK1 RSAD2 IRF7 IFITM2 TRAF3 TRAF6 IRF3 IFIT5 MYD88 TLR3 IFNG OASL TLR7 MAVS PMC3527239__F5 Compartmentalization of the Beta-oxidation pathway and the glyoxylate cycle HEL60 MDH2 PMC9020428__F2 Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine BAD EIF2A PTEN BAX PMC3245119__F2 Non-canonical Wnt-signaling pathway PLN MLEC GNG2 GNAS PTEN MAP3K7IP1 RYR2 PMC1431720__F7 Cytokine release in RAW 264.7 macrophages STAT1 TLR7 TLR4 TLR1 IFNG PMC4914160__F10 Model depicting autophagy receptor recruitment to depolarized mitochondria over time TBK1 PINK1 OPTN PMC8258107__F1 Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation PLCB2 DPP4 CALHM3 CALHM1 TRPM5 TRPV1 PMC7483885__F2 Pathway map for the production of terpenoid compounds CIT IPP MAL PMC4994463__F4 “Inhibition of MMPs” signaling pathway at 1, 4, 7, and 14 days after nerve crush injury.Differentially expressed genes are shown in red (up-regulated) and green (downregulated) TFPI2 A2M AIMP2 MMP2 RECK TIMP4 TIMP3 PMC3398465__F4 Systems analysis of salivary gland development and disease EGF SEMA3A CS SPRY1 HBEGF CTNNA1 BMP4 EDAR GLI3 PLXNA1 SHH SMO SEMA3C PMC6364034__F9 Working model illustrating that KSHV hijacks the citrulline-NO cycle to promote KSHV-induced cell proliferation and cellular transformation ASS1 ASL PMC7905684__F1 Novel targeted therapies for Parkinson’s disease HEL70 LRRK2 SI GDNF GLP1R PMC3929010__F12 Reactive Oxygen Species in Inflammation and Tissue Injury CASP3 TRADD CASP9 JUND TRAF2 JUN FADD BAX PMC2970638__F8 Up-regulation of Paxillin and Focal Adhesion Signaling follows Dystroglycan Complex deletions and promotes a Hypertensive State of Differentiation MAPKAPK2 CS MAX FH ARHA PMC5037279__F6 Proposed model for how mTORC1 activity controls pro-IL-1B expression TSC1 TLR4 TRAF6 MYD88 IL1B PMC3929010__F10 Reactive Oxygen Species in Inflammation and Tissue Injury VCAM1 CXCL8 PMC8332866__F9 Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells EEA1 PIKFYVE ARF6 PMC85825__F9 Model illustrating the relative positioning of aPKC within the NGF signaling cascades for survival and differentiation NGF NGFR SRC PMC10705325__F13 Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC7976587__F3 Possible feedback loop between PTX3 and TNFA via NFKB signaling pathway in inflammation CXCL1 IL1B PTX3 PMC8513144__F1 Brain as an insulin-sensitive metabolic organ RICTOR NRF1 IGF1 MTOR IRS1 PMC11576080__F2 Therapeutic interventions that specifically target signaling pathways in B-cell lymphoma BTK BCR LYN SYK PTEN CD79B CD79A PMC6518034__F2 Schematic drawing of the details of the signaling pathways of five major cardiomyopathies BAD APC PTEN BAX PMC11576080__F1 Major B-cell signaling pathways and their crosstalk BAD PDK2 RELB TRAF3 GIP PTEN MYD88 CD79B CD79A TSC2 BTK CARD11 BCR RELA MDM2 CASP9 CD40 SYK RPS6 PMC8412938__F10 Summary model RETN C1D CFD MGLL CXCL12 ADRB3 PMC6438043__F5 Pathway representing T cell signaling PLCG1 CD3D VAV1 CD8A PTPRC BTK LCP2 NFATC2 BCR CAMK4 BASH LCK GRB2 IL2 SYK CD80 JUN IL2RB PMC3746496__F2 PKM2 activity is controlled by a tight regulatory network at the transcriptional, proteomic and metabolic level EGFR CCND1 HIF1A STAT3 GLS PMC8841346__F1 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System OGA OGT NEUROD1 PMC5467995__F1 Major intracellular pathways leading to Type-I-IFN production STAT1 CGAS STAT2 IRF7 IRF3 IFNAR2 JAK1 IFNAR1 NOD2 TLR3 MAVS PMC8841346__F2 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System OGA OGT IRS1 PMC3634825__F2 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes E2F4 LEFTY1 ID4 NODAL ROCK1 LEFTY2 SMAD2 TGFBR1 MYC FST NOG DCN BMPR2 AMH ACVR2B MAPK1 THBS1 RBL1 INHBC BMP2 AMHR2 SKP1 ARHA TNF RBX1 SMURF1 GIG8 EP300 THBS3 SMURF2 PPP2CA TGFB1 INHBA INHBE PMC2686679__F12 Signaling pathway leading to Egr-1 biosynthesis in thrombin or carbachol-stimulated 39M1-81 cells EGF EGR1 REST PMC3634825__F3 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes ACAD8 OXCT1 BCAT2 HADHB ALDH3A2 OXCT2 HSD17B10 AOX1 ALDH7A1 ACAT1 ACADS IVD ALDH9A1 MCCC2 MCEE HMGCL DLD HMGCS1 ACADSB PCCA DBT PCCB ACAT2 ABAT BCAT1 MCCC1 ECHS1 EHHADH ACADM ALDH2 PMC10865100__F1 Classical model of G1–S transition regulated by cyclins and cyclin-dependent kinases (CDK) CDK2 CDK4 CDC2 MTOR CDK6 TGFBI STAT3 PMC3025359__F1 Mincle- and Dectin-1-mediated signalling in response to mycobacteria CARD9 APC SRC TRAF6 SYK IRAK4 MYD88 PMC11761900__F1 JAK/STAT signaling pathway and the selective inhibition of JAK1 by upadacitinib in inflammatory bowel disease TYK2 JAK3 JAK1 PMC3719407__F4 Functional link between the BMP system and GnRH-induced FSH transcription BMP6 SMAD6 BMP7 FSHB SMAD1 DKFZp781O1323 PMC5442177__F2 Transcriptional regulation of hepatic mIndy mRNA levels in model organisms and humans AHR STAT3 PMC3679268__F7 GSK-3A Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1-TAB Stabilization and Regulation of Non-Canonical NFKB RELB GSK3A MAP3K7IP1 PMC7385848__F1 Bile acid metabolism pathway.Two major pathways are involved in bile acid synthesis CYP27A1 CYP8B1 AKR1D1 AKR1C4 CYP7A1 HSD3B7 PMC3499662__F1 Cell-signaling pathways from the UPR to autophagy and ER stress-induced apoptosis AGA TRAF2 XBP1 BAX PMC6404485__F9 Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage APC CD36 PMC2815088__F5 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine TSC2 EEF2K OGA OGT EEF2 GSK3B PTEN MTOR IRS1 SIRT1 RHEB PMC2815088__F4 The Hexosamine Signaling Pathway IGF1 PDK2 PTEN IRS1 PMC6258484__F5 Pathway network and MAPK signaling SLA CD14 NLK CCK DAO MAX FLNA ATF2 GRB2 ECSIT TNF MEF2C PMC2719943__F1 Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity POMC NPY AgRP MC4R PMC6952937__F1 Two different NFKB signaling pathways LTB RELB TNF IL1B PMC3075579__F4 The PI3K pathway in TLR-signaling TRAF6 IRF3 PTEN MYD88 IL1B RHEB MAL PMC2815088__F6 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine OGA OGT MTOR POLI PMC6337659__F2 Proposed mechanisms of polycystins implication in CRC SRC MTOR PMC5514100__F15 HOXA11-AS co-expressed genes were significantly overrepresented in the non-small cell lung cancer pathway, revealed by KEGG pathway analysis– (http://www.kegg.jp/kegg/kegg1.html) RARA FHIT DAO ERBB2 EGFR CASP9 PMC4512023__F4 PTGS pathway deregulation during colorectal tumorigenesis COX2 COX1 PMC9301135__F1 Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease TSC2 TSC1 KEAP1 IRAK1 HEL-S-28 TRAF6 IRAK4 RAC1 DEPTOR SIRT1 RHEB TAB3 PMC8388841__F1 Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability ATM RAD51 PMC6565612__F1 The roles of the cAMP-PKA and cGMP-PKG pathway in DRG neuron hyperexcitability after peripheral injury or injury- related stress including chronic compression of DRG (CCD) and acute dissociation of DRG (ADD) PIEZO2 GC TRPA1 TRPV1 PMC9376094__F9 TDP-43 suppressing apoptosis by modulating ABHD2 in HCC ABHD2 TG PMC6136178__F8 DACT2 and the Beta-catenin/Cdc25c pathway LEF1 CCNB1 DACT2 PMC5509646__F6 The regulatory network of lipid accumulation with significant characteristics ADFP RRAS2 HEL-S-104 CD36 PMC5167032__F2 Dysregulated Toll‐like receptor signalling associated with advanced age TLR4 IRAK1 IRAK2 TRAF6 IRAK4 IL6 MYD88 TLR1 MAL PMC9218868__F2 Multifunctional Roles of MicroRNAs in Schistosomiasis NR1i1 SEMA4D SMAD2 SMAD4 PMC8952333__F6 Advances in HIV-1 Assembly IQGAP1 GBP5 FURIN PMC2806029__F2 Ammonia detoxification pathway and mitochondrial sirtuins SIRT4 OTC ARG1 ASL PMC8534485__F1 Porphyrias in the Age of Targeted Therapies ALAS1 AIP UROD UROS HMBS CPOX ALAS2 PMC4479729__F1 The synthesis of glycoconjugates from glucose through the hexosamine biosynthetic pathway (HBP) TH OGA OGT GAL PMC10278599__F2 CAR T cell cytolytic mechanisms and paracrine effects TNF IFNG PMC7697636__F1 Classical degradative autophagy (macroautophagy) ATG16L1 ATG12 ATG3 ATG10 DKFZp686F0183 RHEB PMC10308135__F4 Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis opn PMC11889768__F11 Potential pathways by which abscisic acid (ABA) influences 2-acetyl-1-pyrroline (2-AP) biosynthesis in aromatic rice DAO PRODH PMC7286881__F4 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics FGF21 CCL2 HIF1A HMOX1 AGTR2 IFNG SERPINC1 MMP3 FLT1 PLAT IL18 HEL-S-78p KDR NPY F2 LPL VWF LEPR THBS1 KNG1 ACE2 FGA FABP2 NPPA PTGS2 FGF2 MMP9 VEGFA ADRB2 TNF HLA-DRB1 HMGCR RS1 LIPE PLTP LTA NR1C2 F7 PPARG TF PMC5758508__F8 Rationale for the problematic role of B2 adrenergic agonists in clinical trials PC ADRBK1 CFTR PMC7991574__F6 The used inhibitors and the signal transduction pathways involved in BDNF and C3 effects on SGN HEL-S-62p ARHA BDNF PMC8657675__F4 Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance RETN CCL2 PMC5083752__F3 Hedgehog signaling activation in TNBC: interplay of ligand‐dependent and ligand‐independent mechanisms FOXC1 IHH SHH SMO BMI1 HIF1A NRP2 PMC10528641__F2 Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes LATS1 PTEN MTOR LATS2 PMC4472151__F5 Lineage specific differentiation for MSCs in an exquisitely coordinated process with critical regulators and indicators are shown EGF DAO NFATC1 APC SOST HOXC8 SHH TRAF6 SMO PTH MSX2 SKI PMC5083752__F1 Hedgehog signaling cascade HHIP DHH BOC IHH SUFU GSK3B SHH SMO PMC4472151__F4 BMP signaling and its regulation ATF2 APC SMURF2 TRAF6 TFAP2A MSX2 DLX5 SKI ID1 TF PMC2989879__F3 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system NRF1 BNIP3 CITED2 PMC2989879__F2 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system COX2 ATM PTEN CITED2 PMC6368966__F1 Proposed divergent role of Notch signaling in endothelial and smooth muscle cells BMPR2 HEL-S-28 NOTCH1 NOTCH3 PMC6170333__F1 The synthetic pathway for development of the hyperbranched polymer based theranostic nanomedicine incorporating either A8 (HBP/A8/DOX) or A13 (HBP/A13/DOX) BOC PMC4885935__F1 Roles of sclerostin, Lrp4 and Wls in Wnt/Beta-catenin signals in osteoblasts LRP4 APC LRP5 LRP6 PMC7558374__F3 Known functions of FMDV non-structural proteins on immune escape TBK1 TANK ATG12 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 EIF4E NOD2 ADNP STAT1 ELF3 TRAF2 DCTN3 PMC7558374__F2 Known functions of FMDV structural proteins on immune escape TBK1 STAT1 TANK STAT2 IRF9 TRAF3 IRF3 JAK1 TRAF2 RPSA IFNG PMC11033278__F8 PPI interaction network SCO2 OPA3 ACOT13 PYURF TSFM NDUFV3 PC NDUFA12 NDUFB10 NME4 UQCR10 KCNN4 PIGA ZFPM1 UQCRQ FLI1 SLC25A24 HEL-S-25 SLC16A7 SCO1 NDUFS3 COXFA4 ATP6AP2 SLC25A4 COXFA4L3 TCIRG1 GATA2 NDUFB4 NDUFA3 NDUFB3 MTHFS PMC5824531__F1 Signaling pathways linked to Insulin/IGF signaling in PDAC BAD IGF1R IGF2 BCL2 PTEN TBC1D4 FOXO1 PMC10889522__F6 Schematic illustration of YTHDF2 mediating the action of BDNF stimulating the proliferation of porcine follicle granulosa cells YTHDF2 CDK4 BDNF PCNA PMC4411413__F2 Differential expression of genes involved in MAPK signaling pathway in mouse ovaries EGF SET BRAF FLNA PPP3CC NRAS GCK GADD45A CASP2 MAP3K12 MAP3K7IP1 TMEM37 AK2 PAK1 DUSP10 RAP1A MAX HEPH GRB2 ECSIT CSA2 PRKCH BDNF JUN PMC8748746__F2 DFT calculation of biosynthetic pathway of vaticahainol A and B CPD PMC5640934__F1 TGFB superfamily signaling and its involvement in decidualization ACVR1 ACVRL1 BMP2 SMAD2 TGFBR1 ACVR1C TGFBR2 SMAD4 AMHR2 SMAD9 FST BMPR2 ACVR2B BMPR1A ACVR1B SMAD1 DKFZp781O1323 PMC1482580__F4 EDA signaling in hair follicle development EDARADD EDAR LTB RELB SHH SOSTDC1 DKK1 DKK4 PMC8786487__F3 Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids TLR4 KEAP1 MYD88 JUN IL1B PMC11395144__F3 Application of nanotechnology in MS and KOA treatment targeting TRPA1 inhibition SLN GFAP TRPA1 SIRT1 CAMKK2 PMC11395144__F2 Application of nanotechnology in breast cancer and PMA treatment targeting TRPA1 inhibition TRPA1 MTOR RAMP1 PMC9630654__F1 Meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing ARHA RHO SSH1 CDC42 PMC7654410__F1 Neddylation inactivation by MLN4924 treatment or genetic deletion is involved in multiple regulatory responses within immune cells TH CCR5 CCR2 IL6 PMC7504917__F2 Endogenous production of H2S and cross-talk between H2S/RSS and ROS/RNS in bacteria NHS PMC5819906__F7 miRNA-gene network contains six miRNAs and their target genes, which are involved in the insulin signaling pathway PIK3R1 BRAF PHKA1 MAPK10 GSK3B PIK3R3 PDPK1 SLC2A4 PPARGC1A INPP5D GRB2 PIK3CA HK2 AKT3 PMC5819906__F6 Differentially expressed miRNA gene targets in the insulin signaling pathway TSC2 BAD INS EIF4E MTOR FOXO1 RHEB INSR PMC6954688__F8 Activation of the NMRK2 path to NAD+ synthesis as an adaptive energy sparing mechanism in the failing heart NAMPT NMRK2 NR1C1 PMC9323376__F8 Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NFKB Signaling Pathways and Enhancing Osteoclast Apoptosis CASP3 NFATC1 MMP9 DCSTAMP PMC5349656__F1 Hh signaling pathway and RUSKI Hhat inhibitors SMO PMC5682227__F2 PID gene defects in the IFNG pathway IRF8 IFNGR2 CYBB IL12RB1 GATA2 STAT1 ISG15 IKBKB NFKBIA STAT4 CD40 TYK2 JAK1 IFNGR1 PMC4322943__F1 Phosphortlated Smad3 is stabilized by ERG in ERG-positive prostate cancer cells ERG SMAD2 SMAD4 PMC5975185__F1 Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes TBK1 FIG4 IRF3 PMC4180639__F7 Putative model of Ahnak-dependent activation of TGFB signaling SMAD2 AHNAK PMC7898466__F7 TLS pathways for replication through Tg and EdA lesions REV1 POLE POLK TG PMC8146344__F1 Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts COL3A1 ACTA2 SMAD2 MMP9 LRP8 LATS1 IL6 PDE1A HIF1A COL1A1 LATS2 TIMP1 MMP2 PMC7898466__F1 TLS pathways for replication through UV lesions REV1 POLE POLK POLG POLN POLI PMC11786765__F7 MRNA expression of different signaling pathway genes LEF1 WNT4 SMAD2 SMAD4 PMC3820435__F3 Cell death signaling by the ER stress response/UPR ATF4 EIF2A TRAF2 BAX PMC7886236__F3 Insulin-like factor-1 (IGF-1) signaling and the multiple pathway axis IGF1R IGF1 EGFR IRS1 PMC3673972__F10 Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol TBK1 CD14 TLR4 GSK3B TRAF6 PTEN MYD88 TIRAP PMC3037032__F4 The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes C6 KDM2A PMC5831137__F1 Dual-targeting Wnt and uPA Receptors Using Peptide Conjugated Ultra-small Nanoparticle Drug Carriers Inhibited Cancer Stem-Cell Phenotype in Chemo-Resistant Breast Cancer APC GSK3B LRP5 LRP6 DKK1 PMC8945028__F2 Manipulation of Meiotic Recombination to Hasten Crop Improvement SPO11 DMC1 RAD51 MSH2 PMC9437549__F2 Microbial lectome versus host glycolipidome: How pathogens exploit glycosphingolipids to invade, dupe or kill ST8SIA5 A4GALT B3GNT5 B4GALT5 B4GALNT1 ST3GAL1 ST8SIA1 hCG_1998026 B3GALT4 ST3GAL5 B3GALT5 FUT3 PMC9393754__F4 Hypoxia-inducible factor-1 alpha in multidrug-resistant breast cancer DKFZp686F0183 PMC9597307__F1 Venetoclax resistance and solutions NOTCH2 TH BAD SMARCA4 TLR9 FOXM1 ATF3 CD40 PTEN IRF4 STAT3 BAX PMC3408479__F8 Endoplasmic Reticulum Stress Stimulates p53 Expression through NFKB Activation ATF4 EIF2A TRAF2 PMC7298530__F2 Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator MPO CTSS NAGA NCF4 TG RYR2 GAA CTNS OMD TSHR TRH DUT ARC PMC8353059__F2 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases STAT1 ZAP70 JAK3 CD80 JAK1 MTOR BATF PMC8353059__F3 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases STAT1 JAK3 JAK1 PMC8972902__F4 Clinical and translational values of spatial transcriptomics PMEL CRISP3 FTL ERO1A CA9 APOL1 CFTR TYROBP NPY TFF2 TFF1 opn LPL IGLL5 C9orf72 TFF3 B2M APOE PMC7294267__F1 Three mechanisms suggested for the effects of statins and ACEis/ARBs in preventing severe pulmonary disease in COVID-19 ANGPT2 ANGPT1 MYD88 ACE2 FOXO1 PMC3214144__F1 HCMV promotes GBM pathogenesis PDGFRA MMP2 MMP9 GSK3B CCND1 HIF1A FOXP3 PMC3998120__F4 Origins of Metastatic Traits VCAM1 CXCR4 VEGFA SRC CYTIP PMC3669032__F6 Canonical pathway analysis MAPKAPK2 A2M TNF STAT3 PMC11201634__F4 An illustration of the specific Wnt signaling pathway associated inhibitors that have been studied in preclinical and clinical trials for pediatric tumors APC LRP5 LRP6 PORCN PMC11201634__F2 Wnt/Beta-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment APC GSK3B LRP5 LRP6 PMC11201634__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 PMC6218864__F8 Simplified schematic of the effects of nephron-specific Jab1 deletion on the CUL3-KLHL3-WNK pathway KLHL3 OSR1 WNK4 PMC5705551__F1 Major in vivo approaches for tolerance induction and suppression of inhibitor formation in hemophilia PDC BCR APC CD80 MTOR FOXP3 PMC6878006__F6 Predicted localization of proteins and biosynthetic pathways in Synechocystis FDX1 MNT PC F3 FES CYB AMT PMC9709406__F6 Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity EGFR GRB2 PTEN MTOR PMC8774233__F2 Metastatic Progression of Osteosarcomas: A Review of Current Knowledge of Environmental versus Oncogenic Drivers MMP7 COX2 RBPJ TWIST1 MSLN RHO SOX9 PMC8214786__F7 Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect AHR STAT3 PMC4845199__F1 Possible model to explain the involvement of AATF in mTOR pathway AATF DEPTOR DDIT4 PMC10454115__F4 Mechanisms of Pi, Tf, Td, and Cr in AS TLR4 TF PMC4660682__F10 Differential proteins in acute phase signaling pathway in DN summarized in this and previous studies CS F8 FOS HEL-S-92n PMC7350255__F8 Representation of the KEGG protein process in endoplasmic reticulum pathway UBC USE1 CASP12 SI HEL-S-11 ATF4 SVIP SELL PMC8491019__F5 Regulatory network driving shoot lignification in rapidly growing bamboo MYB ND2 PRX PMC7593769__F7 Model of the C. acnes-induced intracellular signaling pathways TBK1 CGAS IRF3 MYD88 PMC3268503__F6 The Chl branch.The first step of the Chl branch is the insertion of Mg2+ into Proto IX POR COCH PMC7230378__F5 Cytoscape analysis considering TRAIL and miR-106b-5p in the apoptosis pathway ITPR2 CTSS MAPK8 NRAS IRAK4 CASP2 BCL2L11 PDPK1 RIPK1 PPP3R1 APAF1 TNFSF10 DAB2IP ERN1 CASP9 PIK3CA BCL2 CASP8 CYCS PMC7947610__F5 Abnormal T cell Activation in GCA GCA PMC3577635__F2 Biochemical pathways leading to resistance to small-molecule epidermal growth factor receptor (EGFR)-targeting drugs such as gefitinib and erlotinib in non-small-cell lung cancer (NSCLC) EGFR PIK3CA AXL PMC8670088__F4 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis TBK1 IRF7 ZC3H7A TRAF3 TRAF6 IRF3 MAVS PMC6923932__F4 The molecular network of differentially expressed proteins in CAVD generated by Ingenuity Pathway Analysis CS DCLK2 HSP90AB1 KCTD8 ZNF215 PSKH1 IL6 ARMC5 TNF ALPK1 GRK7 TAGLN hCG_1641087 C9 INSRR MYO3B HEL-S-269 ANXA2 ZNF74 G2E3 ZBED4 MYLK4 PMC8670088__F3 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis TBK1 IRF3 MAVS PMC9130481__F2 Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition RAB35 APC PMC5623854__F2 Non-apoptotic signaling pathway induced by CD95 PLCG1 EGFR SRC MTOR CASP8 PMC5623854__F1 CD95L is a chemoattractant for inflammatory T cells and triple-negative breast cancer (TNBC) cells MMP3 MMP7 EGFR ADAM10 PMC12157604__F6 Neuropathic pain pathways of Glutamatergic neurons under Mor vs Sal (A) and Mor+Pro vs Mor (B) conditions COX2 FOS BDNF PMC8835757__F6 Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior RAD1 BAD CD37 MEI1 ITGA7 ITGA4 PTEN RAC1 EIF4E BRCA1 RHEB TSC2 BCR FGF10 MDM2 KITLG SYK CSF1 RBL2 CD19 PMC9271452__F3 Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy NDUFAF2 MRPL2 TIMM13 MTX1 MST065 CP PMC3556263__F1 Molecular pathways affected by CR and irradiation IGF1R IGF1 MTOR PMC5239434__F1 NADPH: new oxygen for the ROS theory of aging ME1 HEL-S-26 ME3 PRX MTHFD1L PMC8882093__F2 Helicobacter pylori and gastric cancer: a lysosomal protease perspective CXCL16 HP SRC CCL5 CCL4 CCL2 MCL1 CXCL12 CXCL14 CCL3 PMC5054901__F2 MiRNA function in the immune system PHLPP2 IRAK1 TRAF6 PTEN MYD88 ICOS PMC8004226__F6 Network of putative senolytic compounds with their biological targets HDAC2 RAD51 PTPN6 ACHE JUN PMC8895820__F2 Molecular environment and atypical function: What do we know about enzymes associated with Mucopolysaccharidoses? GALNS GATA3 PMC5529438__F8 Functional involvement of Hh signaling molecules in estrogen- mediated endometrial hyperplasia PCNA PMC10520974__F3 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications TBK1 GPX4 GSK3B HEL-75 MIOX IRF3 MAVS PMC10520974__F4 Regulatory mechanisms of lncRNAs in cancer cell antigen presentation HLA-A ERAP1 TAP2 TRIM71 HEL-S-99n EZH2 HLA-B HLA-C PMC7400772__F1 Immune evasion in EC IL10 CCL22 PMC5343938__F3 Role of the RIG-1-like Receptors (RLRs) signaling pathway in antitumor immunity TBK1 CASP3 IRF3 MAVS PMC4211382__F3 Summary of intravascular/extravascular Hb/heme clearance and cellular/tissue distribution HP CD163 PMC5343938__F1 Toll-like receptors (TLRs) and TLR-mediated signaling pathway TLR5 TLR9 IRF7 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TLR4 TIRAP PMC8670088__F2 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis IL10 HEL-S-30 DPF3 IL6 IL1B HEL-S-133P IFNG PMC10520974__F7 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications CSF1R TGFBR1 TGFBR2 PMC8670088__F1 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis TSC2 TSC1 HEL-S-30 TUG1 HEL-S-133P RHEB PMC9408811__F4 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? TRAF6 IL1R1 MYD88 CSA2 IL17RC PMC6627901__F5 Model for the oncogenic activation of the EGFR signaling pathway and response to therapeutic EGFR-blockade in basal HNSCC EREG AREG EGFR PMC3261822__F3 IPA-based pathway analysis of differential expressed genes ITPR2 PDX1 TNFRSF12A TTK MYC VPS72 BMP4 ACOX1 HEL-S-2 SATB1 MPP3 ELANE AKR1C4 EIF4A3 ARF3 RUVBL2 ADAM9 SCARB1 ANGPTL4 CYP1B1 PCOLCE CTSH NDRG4 EAF1 ISG20 HBB CPD PMC9408811__F2 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? NLRP3 TLR4 MYD88 IL1B TIRAP PMC3437546__F2 HIF target genes encode proteins involved in critical aspects of cancer progression SNAI1 EPO SNAI2 MMP2 ZEB2 BNIP3L TKTL2 ADM HEL-S-133P ANGPT2 LOXL2 TCF3 PLAUR IGF2 MMP9 ENO1 PFKL HEL-S-87p HEL-S-162eP ANGPT1 EDN1 MMP14 GIG8 CTSC HEL113 BNIP3 TGFA TERT PMC7968419__F1 Schematic presentation of possible cross-linkages between PCOS and HT GNRHR AMH CYP1B1 TRH FSHR CTLA4 FBN3 LHCGR CYP17A1 FOXE1 PTPN22 FOXP3 PMC5743625__F2 Epithelial PGR regulates multiple signaling pathways in the endometrium and transuduce signals via uterine epithelial-stormal inteactions PTCH2 IHH PGR WNT4 BMP2 PTCH1 EGFR HAND2 GATA2 PMC9281973__F1 Benefit–risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma SUFU PTCH1 SMO PMC2962956__F1 Toll-like receptor (TLR) signalling and inhibition by viral proteins TBK1 TLR9 IRF7 IRAK1 IRAK2 TRAF3 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TAB3 MAL PMC4039115__F5 Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome? MYC CCND1 BCL2 CDK4 SIRT1 CDK6 PMC1769518__F1 Complement system consists of about 30 proteins that can be activated by 3 different cascades HEL-S-62p C4B_2 C4A PMC4486472__F2 Neural Tube Defects MTHFD2L SHMT1 MTHFD1 MTHFD2 HEL-S-61p MTR DHFR TYMS GLDC HEL-S-51e AMT MTHFS MTHFD1L PMC2841246__F4 COX-2 inhibitors on apoptosis CASP3 BAD CASP9 DIABLO FADD BAX PMC6001373__F12 Working model for the actions of HDAC1/2 in the regulation of nephrogenesis PAX2 SALL1 LHX1 HDAC2 HNF1A OSR1 WT1 HDAC1 SIX2 PMC5346747__F7 Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a GPC5 WNT3A MMP2 TWIST1 APC PMC2984599__F1 TP53 levels determine whether CDKN1A will orchestrate irreversible senescence or quiescence CDKN1A MTOR PMC12064795__F7 Schematic diagram for the mechanism of SYT7-ALDH1A3 axis mediated carcinogenesis in NPC ALDH1A3 SYT7 STAT3 PMC3235896__F2 Transdifferentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into the multiple skin component cells HMGB1 PDGFRA CCR7 PMC11891113__F3 Expression levels of genes in phenylpropanoid biosynthesis, flavonoid biosynthesis, and galactose metabolism pathways under different drought treatments (CK, D9, D12) in C STS CAD GLS PMC7708490__F7 Proposed mechanistic scheme: MELK is critical for metastasis, mitotic progression, and programmed death of LUAD MMP7 PLK1 TWIST1 CDC2 CDH2 PMC8840921__F3 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression CAMK4 CREB1 PMC8840921__F2 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression RELA BIRC3 MYD88 PMC8166894__F3 Dendritic spine remodeling and plasticity under general anesthesia ARHA RAC1 CDC42 PMC3305973__F2 Sixteen genes associated with enzastaurin response were established by pathway analyses and prediction of drug response using an eight-gene signature MLPH RPS27A NEDD4 INSR PMC7022557__F1 PI3K-Akt signaling pathway INS BCL2 MTOR BAX PMC7527410__F1 SARS-CoV-2 viral entry to host cell pathway ACE2 ADAM17 TMPRSS2 PMC3924811__F10 Mechanosignaling in Bone Health, Trauma and Inflammation RUNX2 BMP2 COL1A1 PMC2860235__F7 FunCoup subnetwork of candidate cancer gene RPA1 surrounded by functionally coupled known cancer genes SART3 MUTYH CHFR PMS2 PMC4182853__F1 The current understanding of p38D MAPK signalling and activation EEF2K EBP ATF2 EEF2 PRKD1 PMC5931255__F2 Hedgehog signaling pathway inhibitors SUFU SHH SMO PMC6128202__F1 Main signaling pathways affected in high-grade gliomas NF1 EGFR CDK4 MTOR PMC3248275__F7 Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice IGF1R IGF1 GRB2 CCND1 IRS1 PMC7780992__F1 Conceptual overview of potential mechanistic pathway of Aspergillus fumigatus recognition through pattern recognition receptors in dendritic cells to upregulate IL-10 production and to downregulate allergic hypersensitivity reactions MYD88 PMC6505497__F4 Sprouty2—a Novel Therapeutic Target in the Nervous System? FRS2 GRB2 SRC RAF1 SIAH2 DYRK1A PMC7754343__F1 Simplified schematic of the kynurenine pathway IDO1 NAMPT HEL-S-90n GIG8 KYNU KMO IDO2 TDO2 PMC7336380__F1 TLR signaling and domain organization of TLR8 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 TIRAP PMC3593900__F5 Schematic illustrating how TNF acts via the Wnt pathway leading to the development of the myofibroblast phenotype SMAD2 APC SMAD4 PMC4243360__F1 Pathways of apoptosis FIG4 BCL2 BAX PMC6149803__F1 Mediating the death of dormant tumor cells AHR SRC TYK2 STAT3 PMC2515306__F1 Wnt signaling pathway and its inhibition by AB aggregates APC GSK3B TEF LRP5 LRP6 PMC5419474__F10 NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans RHO UNC79 TRIO PMC7594557__F11 Simplified overview of signaling from common types of DNA damage to the DDR and cell cycle checkpoint pathways SSB MRE11A BRCA1 CDK6 ATM BRCA2 CDK2 TOPBP1 ATRIP RAD50 RAD51 CDK4 CDC2 ATR H2AX PMC4572916__F1 Differential effects of Calmodulin on two key K-Ras4B effector pathways EGFR GIP OTP PMC4459530__F1 Unexpected Functions of NFKB during Germinal Center B-Cell Development: Implications for Lymphomagenesis BCR RELA RELB CD40 LTBR PMC9533094__F1 Minimal residual disease in EGFR-mutant non-small-cell lung cancer NF2 EGFR LATS1 MTOR LATS2 PMC8231866__F1 Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 SIRT2 NAMPT PARP1 NMNAT3 SLC25A17 PARP3 SIRT3 SIRT7 SLC25A51 NMNAT1 SIRT4 SIRT5 SIRT6 NMNAT2 PARP2 SIRT1 PMC6591387__F2 Inflammasome regulatory network TBK1 SIRT2 POLR3A CHUK DHX58 SQSTM1 LRRFIP2 EIF2AK2 RIPK2 NOD2 NLRP3 IL16 IL1B FLI1 FOXO3A NLRP1 IRF7 IRF3 POP1 PTPN22 PTPRC CARD18 TYK2 IFIH1 MEFV PYCARD MAVS PMC8616422__F2 Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC3870072__F4 Subnetwork 1 and 5 of 6 networks in vehicle group PML SLC14A2 HGF RPE65 EBP HOXB1 SLC18A3 TRRAP RGS18 MTA2 SHC3 E2F3 NKD1 USP34 RPS19 BCR BASH SI FDPS FOSB SIN3A RPS27 HOXA10 SP1 ABCC2 PPP2R2A PRX JUN NEUROD6 ARHGEF1 HEL-S-28 DYRK3 HRAS HLA-B PRMT1 RPS25 ZAP70 RPS3 SP3 PMC3870072__F3 Two reversing pathways between the vehicle and baicalin groups HEL-S-11 GRB2 SHE HRAS OTP MEF2C CDC42 PMC8996985__F3 Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC3870072__F5 Subnetworks 1, 2, and 4 of 9 networks in baicalin group RET PAX2 FOS RELA SP1 RAN PMC4900586__F5 Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations MMP10 PLAUR FOXM1 MMP9 SCRN1 SNAI2 PTK7 PDPN PTHLH MMP3 ISG15 TNC COL4A6 MYO1B ITGA6 opn IFI35 AIM2 LAMC2 INHBA TGFBI IFI6 PMC6780497__F4 Enriched extracellular matrix organization pathway in non-type subtype of bladder carcinoma cell lines ITGA1 PLOD1 P4HA1 FBN1 ITGB6 NCAM1 ITGB1 HEL-S-130P LAMA3 PLOD2 TIMP1 LAMC1 LAMA5 PMC7713309__F5 Ingenuity pathway analyses of the dendritic cell maturation pathway (A) and TREM-1 signaling pathway (B) at 72 h post-infection, and expression level of related genes (C) FCGR1A HLA-DQB1 IL12A NOD2 NLRP3 FCER1G IL18 MAPK12 TLR7 TLR4 NOD1 FCGR2B CSF2 IL1A NLRC4 NLRP12 IL6 TYROBP NFKBIA IL36RN LTA TREM1 HLA-DQA1 ZBTB12 TNFRSF1A IL23A CD40 HLA-DMB LTBR CCL3 PMC3013516__F8 The interaction between cPLA2A and TGFBsignaling pathways in hepatic cells SMAD2 TGFB1 PMC9010412__F6 SNORD1C was upregulated in CRC, which activated the canonical Wnt/Beta-catenin pathway and promoted the development of cancer stem cells SOX2 PMC12250560__F4 Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis ATG16L1 RIPK2 NOD2 ITCH PMC8526852__F1 Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants MOS DES IRF3 PMC5971462__F9 Smooth muscle cells differentiation process ROCK2 SMAD4 TGFB1 PMC7346011__F8 The anti-inflammatory mechanism of P22077 TLR4 TRAF6 IL1B PMC2242658__F8 Wingless and integration site growth factor (WNT)-induced epidermal growth factor receptor (EGFR) transactivation WNT1 EGFR SRC SFRP1 PMC12048993__F7 Macrophages with high expression of PD-1 inhibit their anti-tumor immune function STAT3 PMC6365644__F4 Differentially regulated metabolic fluxes and metabolites in gluconeogenesis (A), pentose phosphate pathway (B), TCA cycle (C), arginine biosynthesis pathways (D), and respiratory chain (E) under 2-mg/liter colistin treatment for 1 h CIT CP MAL PMC4063500__F2 Lithium’s autophagy regulation mechanism in various neuropsychiatric diseases GSK3B INS MTOR PMC3190105__F1 TLR-dependent and JAK/STAT-dependent signaling pathways in microglia TANK IRF7 IRAK1 TRAF3 TRAF6 IFNGR2 IRF3 MYD88 TLR1 STAT1 JAK1 IFNGR1 TIRAP PMC11631473__F2 Metabolic pathways for anabolism and catabolism of DAG in model yeast Saccharomyces cerevisiae PC FAT1 PMC5606034__F5 GPR and HDAC co-regulation network related to epithelium metabolism PLCG1 MARS2 MAN2C1 ND4L MAOA MGST3 COXFA4 GPR155 SPHK2 PIK3C2G GPR87 ND6 ENPP2 ND2 POMT2 PMC5606034__F4 GPR and HDAC co-regulation network related to epithelium growth PLCG1 MAP3K11 HDAC10 GPR89B LAMTOR3 SIPA1L2 NR1C2 PRKD3 GPR155 HDAC5 SPHK2 PMC11006178__F12 Proposed schematic model of METTL14 in TLR4-mediated innate immunity and promoting CSFV replication YTHDF2 METTL14 TLR4 PMC5226538__F3 ‘melanoma-enriched’ microRNA miR-4731-5p acts as a tumour suppressor CDK2 SMC3 MDM2 SMAD4 CDK4 DBF4 CDK7 PCNA CDK6 SKP2 MYT1 PMC4096053__F2 Many functions of promyelocytic leukemia nuclear bodies and PML as a negative regulator of the PI3-kinase/Akt/mTOR pathway TSC2 PML TSC1 PTEN MTOR RHEB PMC4494966__F4 Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells SPARC FOXO4 CALB2 ANXA9 SAMSN1 TSPAN8 HAND1 HSPB8 ELMOD3 VOPP1 UMOD TAOK2 MMP3 ERAF GPER NHLRC1 NOTCH4 QPCT IRF8 FGFR3 TNLG2B TAGLN ASAH2 CD151 MRC2 CLDN7 TFAP2C CARD8 TUBB4A PMC7504721__F1 Complement is activated by three canonical pathways known as the classical pathway (CP), lectin pathway (LP), or alternative pathway (AP) SPR HEL-S-62p C9 C7 C6 C1S CP PMC3810612__F6 Schematic diagrams of midsagittal sections through (A) the rainbow trout and (B) rat brains to summarize the contributions and interactions of the serotonergic and corticotropin-releasing factor (CRF) systems in the regulation of food intake CORT AgRP UCN ARC PMC9640632__F1 Probabilistic model checking of cancer metabolism CIT MAL PMC6601390__F3 Molecular characteristics of steroid hormone receptors in endometriotic tissue NR5A1 NR3A2 PGR RERG TNF STAR PMC5085631__F6 Model showing how decreased expression of SRSF2 affects apoptotic pathways in renal cancer cells TNFRSF9 TNFRSF1B TRADD CRADD TRAF2 FADD BCL2L2 BAX PMC9245023__F3 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder NLRP3 IGF1 RHO MTOR IL1B PMC6104123__F1 TGFB induces CD103 expression in tumor-specific T cells and participates in integrin bidirectional signaling HEL-S-28 TGFBR1 TGFBR2 PMC9245023__F1 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder TLR4 RIF1 TRAF6 MYD88 PMC10142983__F6 Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2 FADS2 FADS1 GLA PMC3060778__F4 Comparative and demographic analysis of orangutan genomes NEU3 A4GALT ST8SIA6 HEL-S-111 PMC8064692__F2 NRG/ErbB signaling and downstream signaling pathway EGF NRG3 BAD ERBB3 NRG2 SHE HBEGF MTOR CBL ERBB4 ERBB2 GRB2 TGFA NRG4 PMC8862564__F4 Germline specification from pluripotent stem cells PRDM14 TFAP2C OTX2 SOX17 BMP4 PMC5173082__F4 mTORC2/Akt pathway IGF1R EZH2 HIF1A IRS1 STAT3 PMC3838179__F11 Proposed model for the NOTCH-ROCK pathway and its biological significance ROCK1 NOTCH1 RHO PMC10976354__F2 KEGG enrichment analysis of the SGNI targets RARA ATM CASP9 APP BCL2 PTEN CASP2 CAD TNF JUN BAX PMC8914108__F1 New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption IGF1 PFKFB2 PDK4 MTOR TFAM PMC4419619__F1 Modulation of Insulin-Like Growth Factor-1 Receptor and its Signaling Network for the Treatment of Cancer: Current Status and Future Perspectives IGF1R IGF1 IGF2 IRS1 PMC4375924__F5 Discordant and concordant gene expression in the PI3K-Akt-mTORC1 signaling cascade TSC2 EIF3E TSC1 PTEN EIF4E MTOR DEPTOR EIF4B RHEB MLST8 PMC6401644__F3 PIN1 acts at multiple levels of cooperating cellular pathways PIN1 UNK NOTCH1 CCND1 FBXW7 PMC10889501__F4 Postulated relationship between IL-1B/IL-1RA axis and autophagy signaling pathway in invasive bladder cancer TSC2 TSC1 MTOR PMC8625891__F1 Type of Fat in the Diet Influences Regulatory Aminopeptidases of the Renin-Angiotensin System and Stress in the Hypothalamic-Pituitary-Adrenal Axis in Adult Wistar Rats TH NPY TRH PMC9294202__F3 Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule DKK3 USP9X SLK TNFAIP3 TRAF2 TRIM48 PPEF2 ITCH PMC3886801__F1 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas EGF SRC TTN STAT3 PMC3638038__F1 Pluripotent Stem Cells: Immune to the Immune system? APC CD83 CD80 CTLA4 FOXP3 PMC8198123__F2 Therapeutics Targeting the Core Apoptotic Machinery FADD BAX PMC8515747__F9 Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification RARA KRT19 EGFR GRB2 SHE BCL2 EBAG9 POR HEL-S-130P GLA PMC3474542__F2 Nongenomic and genomic estrogen signaling pathways EGFR HBEGF TF PMC3886801__F2 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas GRB2 IL6 OSM TTN STAT3 PMC9407007__F2 Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review CXCL16 DLL4 CXCL10 CXCR4 IL6 CCL2 CXCL12 IL1B PMC8193943__F2 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy USP15 RNF11 KEAP1 SMURF2 RELA SMAD6 RNF4 TRAF4 PMC8193943__F1 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy SMAD2 SMURF2 SMAD6 SMAD4 TRAF6 CDK9 CDK8 SMURF1 PMC2936527__F1 Synthesizing and Salvaging NAD+: Lessons Learned from Chlamydomonas reinhardtii NAPRT NAMPT KYNU KMO AFMID PMC11997497__F8 Graphic model of dedifferentiation-immunosuppression loop formed by malignant cell and macrophage in ICCMalignant cells and macrophages in ICC are involved in a dedifferentiation-immunosuppression loop IL18 YAP1 LILRB2 LILRB1 VEGFA HMGB2 PMC8283745__F2 Four categories of regulatory mechanisms for nucleic acid-sensing Toll-like receptors TREML4 TLR9 DNASE2 UNC93B1 ECEL1 PLD4 PLD3 TASL SLC29A3 PMC6904658__F2 Probable immunoregulatory mechanisms mediated by gut microbiota as a consequence of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) IL10 AHR FOXP3 PMC10926624__F2 Molecular mechanisms of Trp metabolism in gastric cancer CGAS AHR GPX2 COL12A1 IRF3 STAT3 PMC10945197__F3 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis CXCR3 NRP1 CXCR4 ARHA PTEN CXCL12 PMC10945197__F1 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis MSI1 ARHA FUT4 PTEN CXCL12 MTOR CDC42 PMC7322951__F3 Accumulated lysosomal products on cellular and tissue homeostasis TLR4 TIMP1 PMC4422175__F1 Bile acid biosynthetic pathways CYP27A1 CYP46A1 CYP8B1 AKR1D1 AKR1C4 CYP7B1 HSD3B7 PMC4422175__F5 Farnesoid X receptor (FXR) regulates enterohepatic circulation of bile acids PC ABCG8 ABCG5 NPC1L1 FGF19 FGFR4 CYP7A1 PMC4422175__F8 Farnesoid X receptor (FXR) regulation of hepatic glucose and lipid metabolism in liver, adipocytes, and intestine PCSK9 LPL LDLR FGF19 FGFR4 TG NR1C1 CYP7A1 PMC8662531__F1 CGAS-STING signaling pathway TBK1 CGAS TREX1 IRF3 PMC4422175__F7 Bile acid-activated S1P2 signaling EGFR GSK3B SRC IRS1 CYP7A1 PMC9104626__F3 Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway TH BAD SOCS3 ATF1 MCU FADD BCL6 BAX PMC2147675__F1 Antimalarial therapy prevents Myc-induced lymphoma ATG12 MYC BNIP3 HEL-S-162eP PMC6232724__F9 Schematic diagram of icariin regulation upon PA-induced insulin resistance TXNIP IRS1 STAT3 PMC8047476__F1 Psoriatic arthritis is a multifactor disease TLR4 MYD88 IL23R STAT3 PMC5143759__F2 PIN1 dysregulation and targets in hepatocellular carcinoma PIN1 NOTCH1 CCND1 MTOR PMC4167018__F7 Modulatory effects of low-dose H2O2 on the functions of pDCs PDC TLR7 TLR9 IRF7 CD40 CD83 CD80 MYD88 TNF PMC3079059__F1 Control of intracellular heme levels: Heme transporters and Heme oxygenases ABCB6 FECH UROD ABCB7 ABCB10 CPO PMC8226072__F1 Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research OMP ADSL UMPS PAICS HEL-S-70p CAD DHODH PMC10815326__F7 Different patterns of inflammatory gene activation in cerebral cortex and cerebellum of Npc1−/− mice NPC1 TLR4 EBI3 CKLF CXCL10 CXCL6 CCL7 CXCL3 CXCL12 PMC7068213__F1 Graphical representation of the purine salvage pathway GDA GMPR ADA PNP PMC3689995__F7 Dual functions of Smad2 in the maintenance of hESC and mEpiSC pluripotency CDX2 SMAD2 PGC SMAD1 DKFZp781O1323 PMC5624830__F3 NOD1 and NOD2: beyond peptidoglycan sensing NOD1 RIGI IRF3 TRAF2 XBP1 NOD2 MAVS PMC10544979__F8 The MyD88 and TRIF signaling pathways and downstream responses by the protein-based adjuvants rSIP and FLH in APCs TLR4 APC CD80 MYD88 PMC3899946__F2 Radiation-Induced Bystander Response: Mechanism and Clinical Implications CDS1 ATM CDK2 MDC1 H2AX BRCA1 PMC5624830__F1 NOD1 and NOD2: beyond peptidoglycan sensing NOD1 ARHA RAC1 NOD2 PMC7915460__F2 EphA2 signaling in normal (A) and cancer (B) cells EGFR SRC RHO EPHA2 CDC42 CBL PMC7407580__F1 Involvement of the CCL5/CCR5 axis in cancer progression CCR5 CCL8 MMP2 MSC MMP9 CCL5 CCL4 STAT3 CCL3 PMC3711692__F5 Staufen-mediated mRNA decay STAU1 PMC3064905__F3A Genomic revelations of a mutualism: the pea aphid and its obligate bacterial symbiont NR1A2 THRA PMC9687456__F8 m6A Methylation Analysis Reveals Networks and Key Genes Underlying the Coarse and Fine Wool Traits in a Full-sib Merino Family MYB TSC2 BAD BCR MDM2 PTEN RAF1 GAL IRS1 RBL2 RXRA CD19 PMC8924581__F2 Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators PRDM16 SRA1 ABCG1 CDK5 ABCA1 CDK9 ARG1 SIRT1 CDK7 SUMO1 CD36 PMC5666810__F2 Thrombin cleaves the amino-terminal domain of PAR1 and triggers intracellular signaling MMP9 ARHA MTOR IL1B PMC9525297__F8 Schematic presentation of  process involved in the inhibitory effect of SC on TNBC metastasis EZH2 TNF PMC7022396__F3 Metabolic pathways involved in the de novo synthesis from sugars of floral esters by H PMC4346630__F10 RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL NLRP3 RIPK1 TLR4 TRADD RIPK3 MYD88 TNF TRAF2 IL1B FADD MLKL TRIR PMC4521753__F3 Identification of Oxygen-Responsive Transcripts in the Silage Inoculant Lactobacillus buchneri CD034 by RNA Sequencing PGM3 AIDA RPE PGM5 PMC9424684__F11 Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation NLRP3 MYD88 IL1B GSDMD PMC8857305__F4 Mechanical regulation of bone remodeling BMP2 POSTN SOST GSK3B LRP5 SMAD4 LRP6 ARHA LATS1 LATS2 ROR2 SMAD1 DKFZp781O1323 PMC8857305__F3 Mechanical regulation of bone remodeling PTH1R TRPV4 GPR68 SUFU PIEZO1 SRC SMO RHO PMC3539742__F2 Autophagy and apoptosis- what’s the connection? CASP3 DAP JUN CASP8 FADD PMC2930807__F4 Gene pathway analysis PDE3B PRKAA2 PCK1 ACACA GSK3B ACTN2 TNNC2 FZD4 ATP2A1 NR1C1 PYGM GNAI1 CREBBP FLT1 LIPE LPL ACSL1 MC2R PYGL ABLIM3 PMC8071514__F4 Role of the acetylation pathway in TAp73 regulation SIRT2 LYST NOX4 PMC3403107__F8 The molecular pathway regulating Xenopus lung development SOX2 OSR2 SFTPC OSR1 WNT2B BMP4 PMC5602684__F1 Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12–CXCR4 associated biological regulatory network EGF CXCR4 EGFR MDM2 SRC PTEN CXCL12 BRCA1 PMC11572133__F7 LPAR3 regulates EPO induction by hypoxia VHL LPA LPAR3 PMC2820199__F4 Curcumin’s targets intracellular components implicated in cell proliferation signaling pathway in prostate cancer cells CDK2 EGFR MTOR PMC5270455__F4 Pathway derived from perturbation experiments EDNRA IGF1R FGFR1 CDK2 EGFR RAF1 HDAC5 PMC2820199__F3 Network of proteins, functional classes and cell processes modulated in prostate cancer cells after curcumin treatment NFKBIA EGFR BCL2 PTEN BAX PMC5685770__F2 Therapeutic potential of cell cycle targeting in multiple myeloma CKS1B CDC20 CDK2 APC CDK4 CDC2 CDK6 PMC4606174__F2 Crosstalk between signaling pathways that lead to colorectal cancer progression BAD APC EGFR LRP5 GRB2 LRP6 PTEN PMC7502316__F3 Alterations of Spermatozoa Proteomic Profile in Men with Hodgkin's Disease Prior to Cancer Therapy CCT6A TCP1 CCT4 CCT7 ACR PRSS37 PMC2064427__F10 Schematic diagram illustrating the signaling mechanisms that control the bidirectional responses of the growth cone to BMP7 gradients LIMK1 BMP7 RHO PMC151138__F1 Signaling and transcriptional pathways of Th1 differentiation and the potential role of c-Rel STAT1 APC STAT4 PMC4911353__F5 Interaction and expression pattern of SDEGs involved in canonical interferon signaling pathway in Mtb-infected mouse lungs with or without CC-11050 treatment IFIT3 STAT2 IRF9 IFITM2 IFNAR2 IFITM1 IFNG STAT1 OAS1 PIAS1 IFI35 PSMB8 SOCS1 BAX PMC8662531__F4 Aging and the cGAS-STING pathway TBK1 CGAS DNASE2 TREX1 IRF3 PMC3810296__F2 NLRP6 in Infection and Inflammation TLR4 NOD1 RELA NLRP6 MYD88 AIM2 IL1B NOD2 PMC9261412__F3 Recent Advances on Drug Development and Emerging Therapeutic Agents Through Targeting Cellular Homeostasis for Ageing and Cardiovascular Disease ATF4 EIF2A TRAF2 XBP1 PMC6685071__F2 Impact of oncogenic pathways on evasion of antitumour immune responses BATF3 CD47 CXCL10 APC IL33 MYC CCL5 CCL4 CXCL2 PTEN PMC6610439__F11 NAD(H) recycles (not shown) in redox and dehydrogenase reactions and supplies mitochondria to generate ATP NAMPT NNMT PMC4884942__F1 Targeting Notch to overcome radiation resistance NOTCH2 EGF NOTCH4 JAG2 NOTCH1 ADAM10 FURIN NOTCH3 HDC PMC10505163__F9 Hallmarks of severe asthma and the possible role of the identified mRNAs by artificial intelligence methods TLR4 PTBP1 PTEN MYD88 MTOR PMC6056231__F9 Neural crest induction by Dkk2 and Wnt8 AXIN1 LRP5 SNAI2 LRP6 DKK2 PMC5595898__F6 Terpenoid biosynthesis in M MVD FDPS MVK GGPS1 PMC4741883__F8 Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma EYA1 SPIB TLE4 MAPK7 MSX1 SIX1 MEF2C GATA3 GATA2 PMC7843791__F2 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer OGA OGT PSPH GNAL MGA PMC9034286__F6 Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells GPX4 SLC7A11 RHO PMC7843791__F1 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer TIGAR FBP2 HEL-S-30 FBP1 GSK3B PMC9352111__F5 EIF2 signaling pathway: Male 2-year turquoise module TH INA ACHE PMC9352111__F4 Opioid signaling pathway: Males 7-week green module TH BAD BRAF PMC9592740__F2 Kölliker’s organ-supporting cells and cochlear auditory development CTSK BCAM IRX1 MTOR RPS16 JUN SGK1 COL4A2 APOE PMC7825156__F6 Metabolic disturbances in PD CYP27A1 GCA DIO1 CYP7B1 CYP7A1 HSD3B7 PMC7843791__F9 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer NHS HEL-S-11 ATF4 ASNS NASP PRODH ALDH18A1 CAD PMC7433406__F8 Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NFKB Signaling Pathway HMGB1 TLR4 GFAP IL1B BAX PMC8321659__F9 Scheme showing the main alterations found in aging neurons in vitro NPC1 SREBF2 MTOR PMC2957845__F6 Scheme of the Wnt signalling pathway including proteins from the RT-PCR array SFRP4 FOSL1 PITX2 APC LRP6 PORCN CCND3 CSNK1G1 CXXC4 CCND2 NLK EP300 CCND1 CTNNBIP1 FRAT1 BCL9 PMC7564329__F6 Proposed molecular mechanism underlying increased neural excitabilities and susceptibility to ischemic injury caused by IL-4 deficiency IL4 SCN1A GABRA6 PMC5126841__F9 Schematic representation of the study COX2 IL1B IFNG PMC5337960__F7 Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells SPARC PIK3CD PIK3R1 ABCC3 CD9 SNAI1 CD46 TUBB6 SMAD2 GSK3B MYC NRAS SNAI2 EZR JAM3 SMAD4 HIF1A FOXC2 HES1 FYN MMP2 FRS2 SLC2A3 ZEB2 NOTCH1 SMO GSC CDH2 IL10RA F11R HEL70 TCF3 VCAN APC LCN2 FZD4 KRT18 HMGA2 TNC TUBA1A CXCR4 AXIN1 GRB2 HEL113 TNS1 SYNM MYLK FHL1 F13A1 EGF HGF TGFBR1 EGFR TGFBR2 CSF2RB FZD1 XBP1 ADAM17 FGF20 PDGFD JUP PTPN11 GNG11 MAML1 RBPJ EGR1 MMP9 DTX4 ARHA FGF18 DDR2 SMURF1 IGFBP5 hCG_1998026 DVL1 TAGLN PTPRC GIG8 SDC4 TOB1 PIK3CA RAF1 SRGN BCL9 TCF4 PIK3R2 STAT3 PMC2698936__F2 Integrins in Lens Development and Disease IGF1R GRB2 SRC PMC4741712__F4 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer PIK3R1 PRKCZ IKBKG CHUK KDELR3 UBE2D3 TPM3 KCNMA1 UBE2D4 PDPK1 SELL DCTN6 USO1 UBE2U FYN BCL10 UBE2W YWHAG PRKCI INPP1 UBE2D1 PRKCQ TRIM2 HEL-S-71 VAV1 WIPF1 UBE2H SLC26A2 UBE2D2 LIG1 UBE2E2 UBE2E3 IRS1 tal-1 UBE2E1 CASP3 SIRPA CARD11 CINP ICAM3 RASGRP3 STUB1 LCK LYN RAB24 PMC4058638__F1 Core phosphatases of the PI 3-Kinase pathway PHLPP2 PTEN PHLPP1 PMC5832853__F7 Pathways regulated by selected HPG axis-related hormone and protein in male reproduction as predicted by Pathway Ontology Database and KEGG Pathway Database GNRHR CRH KISS1 NR0B2 CYP11A1 FSHB CGA LHCGR TMF1 NCOR2 STAR PMC3837380__F7 The Potential of 11C-acetate PET for Monitoring the Fatty Acid Synthesis Pathway in Tumors MTOR FASN PMC7072466__F3 Expression profiles of key genes that are involved in the characteristic metabolite biosynthesis pathways in tea plants GC CAD ASL PMC6054847__F3 Effect on eukaryotic translation initiation factors (EIF2) signaling pathway in plasma of total mRNAs obtained from D-tocotrienol treatment of hepatitis C patients ELF1 SUI1 ATF4 EIF2A GRB2 PMC5832853__F8 Mechanism by which ECH enhances the sperm counts GNRHR PROC PMC10967111__F8 RTEL1/JNK/ELK-1 signaling-induced tumorigenesis of glioma RTEL1 TERT PMC11941992__F3 The mechanisms by which visceral obesity is a triggering factor for both systemic inflammation and insulin resistance (IR) NLRP3 TLR4 ANGPTL2 APC INS HEL-S-92n MTOR INSR PMC6970023__F1 Concept of the tubal precursors MIB1 STIL ATM ATR PMC11941992__F2 Three main signal transduction pathways associated with GPR120/FFAR4 stimulation: —ANTI-INFLAMMATORY EFFECTS via beta-arrestin 2 (ARRB2) signaling in immune pro-inflammatory cells NLRP3 TLR4 GIP MAP3K7IP1 PMC4131434__F4 The enemy within: endogenous retroelements and autoimmune disease TBK1 CGAS IRF3 IFI16 PMC6789287__F7 Diagram of Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways CASP3 BAD GSK3B CASP9 PMC4741712__F2 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer IRF7 CXCL10 IRF3 DDX24 ZHX1 IFNG STAT1 IDO1 PRMT1 RPS27A NFKB1 UBE2W RELA PIAS1 IFNGR1 JUN IRF-1 IRF2 PMC4445242__F3 Catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway PLCG1 ITK CD37 GRB2 PMC7851912__F7 The NELFE/Beta-catenin/CSNK2B signaling axis in GC progression CSNK2B NELFE PMC7471355__F3 Different roles of mTOR signaling in stress granules assembly EIF4E MTOR DEPTOR PMC4116492__F1 Targeting FANCD2 for therapy sensitization FANCD2 ATM CDK4 ATR PMC6282995__F1 Retrograde neurotrophic signalling organelles and their main destinations after arrival to the cell body NGF CD63 LAMP2 BDNF PMC7898179__F6 Input-output signal processing plasticity of vagal motor neurons in response to cardiac ischemic injury TH CCK SST NPR3 EBP DBH GRPR TRPC6 VIP PMC11663375__F3 The core regulatory pathways involved skin inflammaging (including NFKB/RIG-I, mTOR, TGFB, AMPK–SIRTs pathways) HEL-S-62p SIRT2 SMAD2 RELB SMAD4 MTOR DKFZp686F0183 GSDMD SIRT3 NLRP3 C9 SIRT4 SIRT5 SIRT6 MASP2 MASP1 MAP3K7 SMAD6 ARHA DEPTOR RHEB SIRT7 SMURF2 ADAM10 SIRT1 PMC4743686__F8 A proposed role of Coa6 in the mitochondrial copper delivery pathway to Cox2 COA6 SCO2 SCO1 PMC7880663__F3 Role of astrocytes in post-traumatic synapse loss and repair MMP3 EPHB1 STAT3 PMC3710315__F2 Identification of STAT target genes in adipocytes LIF OSM PRL IFNG PMC7688896__F2 Signaling pathways that regulate ADF/cofilin phosphorylation and dephosphorylation during LTP and LTD LIMK1 ARHA CDH2 CDC42 PMC11940282__F4 Hepcidin regulation in hepatocytes ERFE BMP6 HAMP KEAP1 BMP2 SMAD6 SMAD4 HFE TFR2 TLR4 SMAD1 JUN DKFZp781O1323 STAT3 PMC8539850__F6 Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress GC ACTR3 MAL PMC8262738__F4 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics CCR2 FYN LCK IL2RG CCR7 A1BG CTLA4 HEL-S-162eP PMC7137223__F4 CeRNA network in this study RNF11 AFF1 TRIM7 PRKAR1A CDK19 TRIB3 KIF1C FOXK1 FAM118A AGTRAP PDPK1 BAZ2A PRKCA SMC1A PACS2 STEAP2 ATXN1 ZC3H4 KHSRP MYO3A PTK2B PURB IQSEC2 GSTM3 ARIH2 SNX27 ZNF609 ZNRF3 USP27X WASF2 LHPP SLC12A7 ANKRD40 RAB3B FBXW8 PTCD3 RAB36 ZNF547 PHYHIP TUB DCAF7 IRAK3 SYNM DDA1 PDE7B MYH9 MLXIP IGF1R MLEC NPTXR ATP6V0A2 DKFZp781B1423 HAVCR2 TPM3 TGFBR2 CFL2 TFDP2 TMEM184B LLGL1 CCDC125 OLFML2A LAMP5 ARPP19 NF2 EPM2AIP1 SLC1A2 SMYD4 ZC3H12B ABHD15 MFRP ZBTB43 KLF13 BLOC1S3 ZNF623 ZNF581 MKI67 FAM131B RBL1 TMEM239 MALL ADD2 HSPA12B SHOX RNF157 SFMBT2 PKNOX1 RPL28 PLXNA1 PEX26 PPIB STX16 HEL-S-93 ZNF783 PMC8262738__F3 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics EPOR HLA-E ICAM2 CD48 TNFSF13 VOPP1 UCP2 SELL ITK BTK FYN OAS2 CD2 GZMA CFP CD3E CD14 CD3D FPRL2 GZMK RUNX3 MS4A1 SAG VCAN TNF GPR18 LTA NFKB2 KLRB1 IL2RG GRB2 SYK CCL18 CR2 FMNL1 LTBR LAT PMC7137223__F3 Integrated protein-protein interaction network in present study AFF1 CLCC1 PRKAR1A STK40 CDK19 TRIB3 KIF1C FOXK1 AGTRAP PDPK1 PRKCA SMC1A PACS2 STEAP2 ATXN1 ZC3H4 KHSRP MYO3A PTK2B PURB GSTM3 DKFZp434B2017 SNX27 ZNF609 WNT7B ZNRF3 WASF2 SLC12A7 ANKRD40 CHAC1 RAB3B FAM168A FBXW8 CACNG8 RAB36 ZNF547 RORA TUB SYNM PDE7B PSMD11 MYH9 IGF1R MLEC NPTXR TPM3 TFDP2 LLGL1 PDE11A RAB15 CCDC125 ARPP19 POU2F1 NF2 EPM2AIP1 SLC1A2 SMYD4 ZC3H12B CCDC68 ABHD15 MFRP ZBTB43 KLF13 ZNF581 MKI67 TMEM239 TRIM73 TRIM74 RNF24 SLC35F1 PGPEP1 ATXN7L3 ZNF562 UBXN2B IPCEF1 ZNF555 ADD2 HSPA12B CXorf58 GOLGA3 SHOX SFMBT2 PKNOX1 RPL28 ICMT PEX26 PPIB STX16 HEL-S-93 ZNF783 PMC8298376__F5 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids TH BAD LTA SET SI TES RELA CRADD CYCS HRK BAX PMC7137223__F2 MiRNAs-mRNAs regulatory network STK40 KIF1C FOXK1 AGTRAP PRKCA SMC1A CYP8B1 STEAP2 KHSRP MYO3A PTK2B PURB SNX27 ZNF609 UGGT1 WNT7B LHPP SLC12A7 ANKRD40 RAB3B FAM168A CACNG8 RAB36 ZNF547 RORA TUB DCAF7 SYNM PDE7B PSMD11 MYH9 MLXIP MLEC NPTXR ATP6V0A2 HAVCR2 TPM3 CFL2 TOR1AIP2 EIF5 MACC1 RAB15 CCDC125 LAMP5 ARPP19 POU2F1 NF2 CCDC68 ABHD15 ZNF623 ZNF581 VANGL1 MKI67 RBL1 TRIM73 TRIM74 RNF24 SLC35F1 PGPEP1 ATXN7L3 ZNF562 MALL ZNF555 ADD2 HSPA12B ZNF607 MAST3 GOLGA3 CLN8 OATL1 ZBTB8B PKNOX1 RPL28 SSR1 ICMT PEX26 PPIB STX16 HEL-S-93 ZNF783 PMC4167887__F1 Schematic overview over the creatine pathway HEL-S-20 HEL-S-29 PMC4642568__F2 RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli PIN1 IKBKE CHUK TANK IKBKG ATG12 IRF3 RNF125 IKBKB NFKBIB MAPK12 TMEM171 NFKB1 CYLD TRAF2 MAVS PMC5499521__F1 Curious origins of Angioimmunoblastic T-Cell Lymphoma FYN STAT4 CXCR5 ARHA IL6 ICOS BCL6 STAT3 TET2 PMC9656460__F1 Ferroptosis of Endothelial Cells in Vascular Diseases GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 DHFR POR PMC11968978__F4 Crosstalk between Wnt and FGF signaling pathways FRS2 GRB2 PMC11968978__F3 Overview diagram of Hedgehog pathway, Notch pathway and TGFB pathway HES5 DHH IHH SUFU SMAD2 DLL4 JAG2 SMAD4 SHH SMO DLL3 HES1 PMC11968978__F2 Non-canonical Wnt pathway signaling encompasses two major branches: the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway NLK DAAM1 ATF2 ARHA RYK ROR2 ROR1 PMC11968978__F1 Canonical Wnt pathway signaling SOX2 RNF43 APC EGFR MYC LRP5 LRP6 TNKS PMC2762706__F3 Hypoxia signaling pathway in DM patients 4d post-CPB/C EPO VHL VEGFA HEL-S-133P SUMO1 PMC11968978__F8 Wnt signaling pathway in various cancers, including colorectal cancer, hepatocellular carcinoma, lung cancers, chronic myeloid leukemia, triple-negative breast cancer, melanoma, and glioblastoma multiforme FZD3 ATF2 APC GSK3B LRP5 HCCS ARHA RNF146 RAC1 MTOR DVL3 ZFX DAAM1 TSPAN12 HNF4A BCR CCND1 GREB1 PMC5835104__F2 The RT2 Profiler Array gene expression data using Ingenuity Pathway Analysis (IPA) software TRAF6 CCL5 CCL4 TLR3 MX1 STAT1 NFKBIA TLR7 CSF2 IFIH1 JUN IRF-1 IL1B PMC7692350__F1 Molecular signaling pathway underlying NETs formation induced by different stimulus TLR4 MPO SRC PMC11968978__F6 Wnt signaling pathway plays a crucial role in modulating the immune microenvironment of tumors IDO1 IGFBP1 LRP5 LRP6 CCL4 FOXP3 PMC11968978__F5 Wnt signaling pathway in cancer stem cells (CSCs) RNF43 LRP5 CD44 LRP6 RYK GPR49 PMP22 ROR1 LRP4 BCL2 ROR2 EZH2 HOXA5 PMC1087506__F8 IRAK1 functions in the TLR and IL-1B pathway upstream of convergence with the TNFA pathway TRADD FOS TRAF6 IRAK4 MYD88 TRAF2 JUN PMC8914279__F1 Association of Viral Infection With the Development and Pathogenesis of Systemic Lupus Erythematosus BCR BACH2 EZH2 ME3 XBP1 PMC8305981__F2 Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells LPA GDPD3 PMC11968978__F9 Small molecule therapeutic drug map targeting all parts of the Wnt pathway COX2 RNF43 COX1 APC GSK3B LRP5 LRP6 PORCN RYK DKK1 PMC4157753__F1 Retinal degeneration in animal models with a defective visual cycle LRAT RPE65 ABCA4 RPE PMC4882250__F5 Characterizing strain variation in engineered E. coli using a multi-omics based workflow CS LDHD RPE PMC7884239__F1 Role of ACE (angiotensin-converting enzyme)-2 in the pathogenesis of coronavirus disease 2019 (COVID-19) ACE2 ADAM17 PMC11802338__F3 Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation RIPK3 PGAM5 MLKL PMC11802338__F2 TNF‐A/TNFR1 mediates the major signaling pathway of necroptosis TRADD C7 TNF TRAF2 FADD PMC3356006__F2 Central regulation of leptin signaling, autonomic innervation of the adipocyte and Beta-cell, and the starvation response MARCKS LPL TG PMC12250049__F1 Hippo signaling pathway TEAD3 TEAD4 LATS1 MOB1A MOBKL1A LATS2 TEAD2 PMC8226607__F1 Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target NAPRT NAMPT HEL-S-90n SARM1 PMC10040812__F8 Signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet B cells in response to high glucose SRC ARHA RAC1 PMC5348403__F4 Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway ITGA1 MCAM ITGB3 MMP9 VEGFA DVL2 ITGA2 PMC6896004__F9 A proposed pathway of DOCK1 in the regulation of growth and motility of CLBC cells RRP1B DOCK1 RAC1 PMC5405508__F6 Network analysis of apoptotic genes modulated in response to V3000 and V3034 infections in spleen at 24 h pi MAFB BRAF ST8SIA4 S100A10 HSPA2 CCL21 LCN2 LIMS1 OAS1 CCNI SCD CD2 GNG2 SATB1 DCT ILF3 REV3L SKI TRIM24 S100A4 PPP2R2A PTTG1 IFI16 RB1CC1 PMC5405508__F8 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in brain EGR1 SOCS3 STAT2 FOS SPDEF SAA1 IGBP1 NFKBIA VCAM1 ERBB2 CD2 CAMK1D EPHA2 OSM PMC9121494__F1 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer RORB RORA NPAS2 NR1D1 PMC12104300__F2 Interactions of the Eph/ephrin system in adenoid cystic carcinoma (AdCC) EFNA1 EPHA2 PMC5405508__F7 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in spleen HLA-A ANXA2 FPR2 ARHA CCL5 HSPD1 PSMB9 PSMB8 SOCS1 PMC12104300__F1 Eph/ephrin signaling in oral squamous cell carcinoma (OSCC): regulatory pathways, tumor progression, and therapeutic implications MVD EFNA4 EGFR EPHA1 EPHA7 EPHA8 EFNA3 MTOR EPHA2 EPHB4 EPHB6 EPHA4 PMC6440158__F9 A working model of circPPP1R12A-73aa on promoting tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway LATS1 LATS2 PMC9121494__F2 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer SMOC2 TIMELESS CSNK1D CRY2 GSK3B ARHA PARP1 MTOR NPAS2 PER2 PMC7780023__F4 TET2: A cornerstone in normal and malignant hematopoiesis TRAF6 STAT3 TET2 PMC2933229__F3 The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas MYC ATF3 OLIG2 PMC4538774__F4 Representation of the adherens junction pathway map from KEGG NLK FER IGF1R FGFR1 IQGAP1 SMAD4 SRC ARHA LMO7 CDC42 INSR PMC3367865__F3 Molecular Biology of Lung Cancer: Clinical Implications NF1 TSC2 KIT TSC1 RASSF1 ERBB2 EGFR STK11 CCND1 MTOR PMC8912576__F2 Mining of Potential Gene Resources for Breeding Nutritionally Improved Maize PC LPA PMC3367865__F5 Molecular Biology of Lung Cancer: Clinical Implications BAD CDK2 MYC MDM2 CCND1 BCL2 CDK4 SEMA3B PTEN CDK6 BAX PMC3367865__F4 Molecular Biology of Lung Cancer: Clinical Implications BAD EPO GSK3B PTEN HIF1A MTOR CDK6 TSC2 TSC1 MDM2 STK11 CCND1 CDK4 JAK1 TGFA PMC3366440__F1 Protective and pathogenic functions of Th17 cells LTA IL17F IL17A IL-21 STAT3 FOXP3 PMC4855030__F5 Interaction network of innate immunity related proteins TUFM ELAVL1 YBX1 DDX1 FXR1 DDX3X PCBP1 ILF3 MOV10 CRK RPL19 CALM1 PMC7524833__F1 Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor PLCG1 ITK APC LCK VAV1 IRF4 LAT PMC3896120__F8 Schematic diagram of EGFR-invadopodia signaling pathways altered by Abl inhibition in HNSCC EGFR SRC HBEGF PMC5992580__F1 Gene clusters identified via gene interaction analysisLines indicate a physical interaction, as assigned by the GeneMANIA plugin for Cytoscape FGA PALB2 NBN MAP2K3 LIMS1 BRCA2 DCTN1 TNFRSF10B MSH2 ATR PRKDC CEP164 CASP8 ACIN1 PMC5395663__F1 Mesenchymal-­epithelial interactions during digestive tract development and epithelial stem cell regeneration CDX2 FOXF2 SHH SFRP1 SOX9 GATA3 FOXF1 BARX1 PMC5833418__F9 Summary of the mechanism of NCK1-AS1 in CC cells SP1 PCNA PMC7190872__F1 Toll-like receptor pathways TLR5 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC7190872__F2 Crosstalk between TLR4, NLRP3 inflammasome, and complement promotes neuroinflammation in Alzheimer's disease NLRP3 TRAF6 MYD88 IL1B TIRAP PMC7072681__F1 Growth factors, such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF) bind receptor tyrosine kinases (RTKs) on the cell surface EGF EGFR CDK4 MTOR PMC8572559__F2 JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms STAT3 PMC3275500__F1 The Ras-MAPK and TGFB pathways SMAD2 GRB2 SMAD4 PMC6234768__F6 Mechanistically distinct regulation of VEGF secretion in MDA-MB-231 TNBC and T47D (ER+/PR+/HER2-) cells EGR1 LIF SP1 HIF1A OSM PMC3367865__F6 Molecular Biology of Lung Cancer: Clinical Implications APC GLI3 GSK3B SMO HES1 PMC3124653__F1 Systems pharmacology assessment of the 5-fluorouracil pathway GGH DPYD UCK2 DPYS UMPS NME2 UNG FPGS TK1 TNFSF6 RRM1 RRM2 NFKB1 DHFR DTYMK TYMS DUT FDXR PMC11215755__F3 Signalling and epigenetic mechanisms limiting the efficacy of PI3K inhibitors PI3 CCND1 CDK4 PTEN INPP4B BRCA1 MLL2 CDK6 PDPK1 PMC3124653__F6 Systems pharmacology assessment of the 5-fluorouracil pathway GGH DPYD UCK2 DPYS UMPS NME2 UNG FPGS TK1 TNFSF6 RRM1 RRM2 NFKB1 DHFR DTYMK TYMS DUT FDXR PMC7886970__F3 CD40/CD40L signal pathways TRAF5 TRAF1 TRAF3 RELB SRC TRAF6 JAK3 TRAF2 STAT3 PMC11215755__F1 PI3K pathway in non-malignant cells and cancer TSC2 TSC1 PTEN PDPK1 RHEB PMC2697682__F1 Interaction of AEA with CB and TRPV1 receptors and its metabolism by FAAH and COX-2 COX1 FAAH TRPV1 PMC9661339__F2 NLRP3 Inflammasome in Parkinson’s Disease and Therapeutic Considerations NLRP3 TLR4 CD36 PMC9120845__F2 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome LYZ PITX2 SLC6A19 AADAT LPO POR KYNU EPX KMO STS HBB ELANE BCL9 PMC9120845__F1 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome CCR5 CCR2 ALB DKK1 CD74 POMC CSF2 IL10RA LYZ LRP5 LRP6 CTNNA1 CD69 IL10RB TNFRSF1B MC4R IQGAP1 OPRK1 AGRN EGFR GPX1 RELB IL1R2 CD81 HBA2 RSPO1 TLR4 CRP ELANE AXIN2 ACE2 TCF7L1 CD19 HMGB1 IL10 CD14 CD3D TJP1 CCL11 PITX2 SLC6A19 SKP1 FCGRT NFKBIA LEF1 EP300 HP AGER KREMEN1 ERBB2 LCK TRAF2 FADD BCL9 PMC7171049__F6 MiR-29c alleviates renal fibrosis via TPM1-mediated suppression of the Wnt/Beta-catenin pathway TPM1 APC TGFB1 PMC5564444__F1 DNA damage and its links to neurodegeneration FEN1 PARP1 LIG1 APTX PNKP PCNA TDP1 PMC9584744__F2 Effect of Liraglutide on Serum TSH Levels in Patients with NAFLD and its Underlying Mechanisms TNC BAD HP MGA PMC4523383__F1 Synthesis of estrogen, progesterone and testosterone from cholesterol HSD3B1 CYP11A1 HSD17B1 PMC9393179__F3 Favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms IRAK1 IL1B IFNG PMC6468558__F2 Summary and functional network target analysis of ginsenoside Rb1, which exerts significantly anti-obesity, anti-hyperglycemic, and anti-diabetic effects on diabetes via multiple links across regulatory mechanisms and multi-target effects IL16 EBP RB1 PMC5958082__F2 ADT DEGs enriched in integrin signaling pathway-associated transcripts ARSK ZYX HEL114 PMC7918591__F4 Crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle pathway (CETCH pathway) MMD HBD PMC4355473__F2 Change in TNFR1 signaling pathway in 3 h, 12 h, and 24 h groups after cerebral ischemia-reperfusion injury TRADD GCK HTRA2 FADD BAX PMC7075814__F3 Synthesis, release, and activation of TGFB signaling via the canonical pathway SMAD4 TEC PMC4727203__F1 Regulation of actin cytoskeleton pathway FGF21 FGF4 EGF F2R BRAF CFL2 SSH2 WAS FGF20 SSH3 F2 HEL114 FGF22 ROCK2 HEL70 ARHGEF4 MOS ARHGEF7 PDGFRA SOS2 CSK WASF2 FGF2 BAIAP2 APC FGFR3 RRAS FGF16 ABI2 FGF18 FGF12 RRAS2 CRK GNG12 RAC3 APC2 SOS1 FGF14 MYLK CDC42 PMC6215844__F2 Iron and inflammatory signaling to hepcidin BMP6 HAMP BMP2 SMAD4 TMPRSS6 HFE JAK1 SMAD1 TF DKFZp781O1323 TFR2 STAT3 PMC7075814__F4 Signaling via the non-canonical pathway of TGFB TRAF6 ARHA MTOR SMURF1 PMC524242__F1 Proposed schematic of chemokine-induced traffic and activation of DCs following DNA vaccination with plasmid-encoded Flt3L and MIP-1A APC CCR7 CD83 CD80 PMC6280292__F8 Antitumor effects of emodin and chrysophanic acid EGFR SP1 MTOR PMC2694412__F6 Somatic mutations affect key pathways in lung adenocarcinoma EGFR APC PTEN RB1 MTOR CDKN2A INSR TSC2 NF1 TSC1 ATM MDM2 STK11 PMC8318568__F2 An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria GC DDT PMC9294349__F2 Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway TBK1 ISG15 OAS2 IRF7 IL13 IRF3 IL1B MAVS PMC4671321__F5 Predicted model for the action of GSK3B in buffalo embryonic stem ( ES ) cells LIF GRB2 DKK1 PMC8261484__F1 NAD+ synthesis pathways NAMPT SLC6A19 SLC29A1 SLC12A8 NAPRT HAAO SLC22A13 HEL-S-90n SLC5A8 KYNU KMO AFMID SARM1 SLC29A4 SLC29A3 PMC5653760__F6 Resveratrol has multiple biological functions that are relevant for AD BACE1 MID1 APP ADAM10 MTOR PMC8096869__F2 Proposed stem cell concept for the development of leiomyomas MED12 CD34 CD44 PMC12250459__F4 Neuroprotective mechanisms of AOF BAD TRAF6 IRAK4 MYD88 MTOR MAP3K7IP1 TSC2 TLR4 IGF1 GRB2 SRC REL BDNF BAX PMC7594413__F2 The MAPK pathway is here shown BRAF GSK3B GRB2 PMC9301111__F2 Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant TSC2 EEF2K ERBB4 SIAH1 EEF2 NRG1 BDNF RHEB HEL-S-162eP PMC6704159__F7 The cooperation between M and P proteins to inhibit different Jak-Stat-pathway steps STAT1 ISG15 TYK2 JAK1 PMC6024232__F2 The pathway of acylceramide synthesis in keratinocytes ELOVL1 ELOVL4 CERS3 KDSR CYP4F22 PMC5245686__F2 Metabolomics and Metabolic Diseases: Where do we stand? HEL-S-26 PC CIC PMC4928174__F2 Canoncial and non-canonical Reelin signaling CDK5 DAB1 CDH2 PMC3491089__F4 Schematic representation which shows possible mechanisms of action by D- and Gamma-tocopherol in multiple signaling pathways involved in mammary carcinogenesis CASP3 KEAP1 CASP9 CCND1 BCL2 CDK4 PTEN PCNA CDK6 BAX PMC4928174__F1 Core Reelin signaling pathway VLDLR GSK3B CDH2 CRK PMC7696795__F1 Activation of JNK by proinflammatory cytokines TNFA and IL-17 leading to autoimmune arthritis TRADD TRAF6 TRAF2 PMC10869406__F5 Relationship between major genes and the PI3K/AKT/mTOR signaling pathway ROCK2 CTSL EIF4A1 CAMK2D ANXA11 RTKN MAP2K2 HEL-S-47e ARHA EIF4E MTOR CD74 HEL-S-130P CALM1 ARHGAP1 IGF2R PMC8935230__F8 Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/GAi2/YAP signaling LATS1 ACAN POR COL2A1 MTNR1B PMC5256616__F4 RGS6 in central nervous system diseases TH HP RGS6 PMC5964982__F2 Notch signaling pathway NOTCH2 RBPJ TGFBR1 TGFBR2 NOTCH1 ADAM10 FURIN HEL-S-14 NOTCH3 PMC5256616__F6 Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast ATM DRAM1 RGS6 BAX PMC8263635__F11 ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer ERG ELOVL5 ELOVL2 BMF TGFB1 MLST8 PMC9537819__F1 Dietary meat mutagens intake and cancer risk: A systematic review and meta-analysis NAT2 PHIP CYP1A2 PMC8269395__F5 Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control PAX7 IL6 MYOG STAT3 PMC3459479__F1 RAS pathway and its correlation with RASopathies CS BRAF GRB2 SPRED1 SHOC2 SOS1 CBL PMC2706609__F1 ERK1/2 pathway in airway epithelial cell responses to cigarette smoke EGF EGFR GRB2 RAF1 SP1 PMC12214337__F12 Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes MMP11 SNAI2 SDC3 PMC8054829__F1 Type I interferon in the pathogenesis of systemic lupus erythematosus IRF7 STAT4 MYD88 PMC8170976__F9 Parkinson mice show functional and molecular changes in the gut long before motoric disease onset CALB2 TPM1 HEL-S-14 UBE2V1 ARPC4 PTPRN VAMP2 SCGN ATOX1 HEL-S-77 NAPG SYNM NEFL PMC3739200__F1 Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway GRB2 RAF1 BDNF PMC6769444__F5 Proteasome pathway mapping of altered genes in DLD-1-miR-21 cells REN POMP ARC RP2 RMI2 RPE RPN1 IFNG PMC7192829__F2 Regulatory mechanisms involved in vitamin D-induced autophagy TLR8 NR1i1 TFEB HEL-S-11 TLR1 MTOR PMC1449579__F1 F igure 1.— RAD18 PCNA PMC7710911__F2 ACAs and CENP-B: CENP-B bound to CCR3 CENPB CCR3 EGFR SRC HBEGF PMC7870526__F2 Metabolic regulation of lung myofibroblast activation PSAT1 F2 PSPH HEL-S-51e PHGDH HK2 GLS PMC12061715__F4 Analysis of the mechanism of skeletal muscle atrophy from the pathway of decreased protein synthesis SOCS3 ATF4 SMAD2 SMAD4 GADD45A MSTN STAT3 PMC4429297__F4 Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer EGF CYP3A4 GPRC5C EGFR E2F5 ABCA3 SEMA3C HEL110 PIGN CRTAC1 E2F3 PMC12061715__F2 Detailed mechanism of GSK3B involvement in reduced protein synthesis RICTOR IGF1 IRS1 NFATC3 PMC6382829__F5 ZINC24469384 regulates genes involved in P53 and STAT signaling pathways HEL-S-11 GRB2 IL6 MTOR JUN CEBPB PMC7079998__F3 STAT3 roles in viral infection: antiviral or proviral? SOCS3 EGFR SRC MTOR STAT3 PMC9096207__F4 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination CXCR1 CCR2 HEL-S-104 STAT3 CD36 PMC3480720__F1 Innate immune signals during B STAT1 TLR9 NOD1 ADA IRF3 MYD88 NOD2 TIRAP PMC7714782__F1 Response of methionine metabolism in the liver HEL-S-61p MTR PMC9096207__F3 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination HGF HMMR POSTN CD44 NOTCH3 PMC9096207__F2 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination POSTN CCL22 STAT3 PMC7714782__F3 Metabolism of methionine in viral infections of hepatitis B and C STAT1 PRMT1 MAT1A PIAS1 PMC1449579__F5 F igure 5.— POLG RAD18 PCNA PMC2786169__F4 Topology of leukemia-related BCR-ABL pathway STAT1 BAD BCR MYC GRB2 CRKL PMC8395751__F10 Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model INA SOX2 PC RIF1 DUSP9 GEM APC SKA1 HAND1 PMC9423733__F1 Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease ULK1 ATG12 ATG3 AMBRA1 ATG101 ULK2 ATG10 DKFZp686F0183 PMC5360635__F1 Autophagy mechanism ATG16L1 ATG12 ATG3 DKFZp686F0183 PMC4637888__F4 Novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway STIL SUFU CYC1 SHH SMO PMC1934395__F2 Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events THBD F5 APC CRP TG PMC11645450__F3 Regulatory roles of the DUB family in signaling pathways USP19 USP21 ATF2 SMAD2 TRAF3 TRAF6 SMAD4 MYD88 USP11 STAMBP USP14 CYLD HEL-117 USP22 OTUD1 YAP1 APC YOD1 PAXX TSC1 GRB2 USP4 OTUB2 USP15 USP26 TRADD OTUD7B PTEN LATS1 MTOR SLMAP LATS2 USP9X WWC3 WWC1 USP2 ATXN3 SMAD6 MAP3K7IP1 USP32 SIKE1 USP16 RELA CD40 RAF1 WWC2 TRAF2 OTULIN OTUD5 LTBR TIRAP USP1 PMC7760721__F2 AB peptides are derived from the processing of the BAPP (APP) through the amyloidogenic pathway ATF4 CALHM1 CA12 XBP1 PMC7816272__F3 Dysregulation of NCC and TRPM6 common regulatory pathways TRPM6 DCT OSR1 TRPM7 PMC7057764__F1 Impact of lactic acid on tumor angiogenesis MMP9 ARG1 PMC6610018__F3 Interplay between the cGAS-cGAMP-STING pathway with mTORC1 signaling TBK1 TREX1 IRF3 PMC6610018__F2 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders TBK1 CGAS IRF3 PMC4048856__F2 HEPCIDIN AND IRON HOMEOSTASIS BMP6 HFE TFR2 PMC2645306__F2 Migration of Airway Smooth Muscle Cells SRC ARHA CDC42 PMC11453023__F7 TLR-activating and the induced signaling pathway TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TRAF2 TIRAP TAB3 PMC10488294__F3 AML cell differentiation by S100A9 TLR4 S100A8 S100A9 PMC5766549__F6 Milk protein synthesis in bovine mammary gland CRH GC INS PRL PMC12016237__F2 Mechanisms proposed for the AS-IV action in animal models of cardiovascular disorders NLRP3 SMAD2 TNF GSDMD PMC5766549__F4 Activators and repressors of the regulatory network of genes associated with the bovine milk K-casein content OLAH PCLO CDON STAC SI F11 CIT ACR PMC6319272__F2 Schematic depicting the proposed hypothesis that resistance exercise-induced adaptations may require the Hippo pathway effectors YAP and TAZ MAP4K2 MAP4K3 LATS1 MOB1A MOBKL1A LATS2 HEL-S-31 MAP4K1 PMC4803054__F7 Models depicting the multifaceted role of Mte1 in RF repair and CO promotion SMC6 RMI1 SMC5 PMC11651441__F11 Inflammatory signaling pathways of SYGCT therapy for asthma-IBS TBK1 TRADD DAO TRAF6 CCL2 USP25 IL17RB S100A7 FOXP3 COX2 AHR IRF4 GATA3 MEI1 FOS MMP9 CXCL10 APC LCN2 CXCL2 S100A9 TNF RHOD JAK3 JAK1 RORA FADD LAT TRAF4 TAB3 PMC9200548__F3 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy TSC2 ULK1 TIPARP MTOR PMC2761108__F8 Roles of BMP signaling pathways during SNS development TH ASCL1 DBH PHOX2B SMAD4 HAND2 GATA3 PMC9200548__F1 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy GRB2 BCL2 ARHA BNIP3 MTOR PMC6682745__F1 WNT/Beta-catenin signaling and the potential role of heterotrimeric G proteins LRP5 LRP6 PMC7834777__F8 Predicted mechanism after administering TCN in the liver NR1C1 UCP2 PMC10149931__F9 Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction FYN LCK CDC42 DGKA PMC3836831__F2 Model of PfEMP1 head structure divergence PC APC CD36 PMC4704136__F2 Cellular and molecular interactions between CLL cells and the tissue microenvironment CXCR5 CCL4 IFNG CXCL13 BCR VCAM1 CXCR4 MSC CD40 SYK IL4 CXCL12 CCL3 PMC4532781__F1 PolyQ-HTT impairs autophagy ROCK1 HTT MTOR HAP1 PMC12125588__F3 Ginsenoside Rg1 in modulating myocardial hypertrophy and fibrosis PINK1 CASR MMP2 MMP9 RELA SIRT1 PMC12125588__F2 Ginsenoside Rg1 in protecting ischemic myocardium NLRP3 PINK1 TLR4 HEL-S-44 ARHA MTOR OPA1 HEL-S-22 PMC6823243__F3 SHP-2 in cytokine receptor signaling PI3 GRB2 MTOR PMC6823243__F2 SHP-2-mediated activation of ERK GRB2 SRC PAG1 PMC10380887__F1 MTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease TSC2 TSC1 GC SIK3 PTEN GRB10 TNF DEPTOR RHEB PMC6514310__F2 Upstream and downstream of mTORC1 and mTORC2 NPRL2 ULK1 C16orf35 DEPDC5 SLC38A9 SEH1L MIOS TBC1D7 WDR24 PTEN MTHFD2 RHEB TSC2 TSC1 SZT2 CAD PMC6514310__F1 mTORC1 and mTORC2 RICTOR MTOR DEPTOR MLST8 PMC7432101__F1 Cartoon representation of DGK signaling in cancer MYC CCND1 SRC RHO HIF1A MTOR PMC6274804__F1 Schema illustrating the regulation of the autophagic pathway under diverse stressful conditions in cancer cells ULK1 ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 PMC3637678__F1 MicroRNAs regulating myogenesis via PI3K/Akt signaling IGF1 PTEN PMC2839263__F2 Emerging models for the role of Beta-arrestin in wingless (from Drosophila) and the oncogene int-1 (WNT) signalling LRP5 LRP6 ARHA RYK ROR2 CDC42 PMC7859115__F3 Cellular and molecular features of autophagy ULK1 ATG16L1 ATG12 ATG101 MTOR DKFZp686F0183 PMC3146004__F4 Pathway assignment of the important genes based on KEGG ARHH RAE1 NODAL CDK2 CA14 SKP1 SP1 PCNA SKP2 IFNG MAL MYT1 PMC7857022__F1 Class I PI3K signaling pathway simplified TSC2 TSC1 BCR PTEN RHEB PMC5615147__F2 Regulations of Nrf2 by several factors AHR KEAP1 SIAH2 JUN PMC4775111__F10 Scheme and coexpression network for a putative flavonol synthesis pathway in tobacco flowers PMC6928039__F7 CR3 triggers the Syk/calcineurin/NFATc pathway upon engagement by PGL-I-producing mycobacteria to rewire the innate response CARD9 IL16 BCL10 SYK MYD88 TNF PMC11877449__F3 Interactions in the Tumor Microenvironment (TME) Affecting Lung Cancer Progression VEGFA PMC12220482__F2 Mechanism of NUSAP1 in cancer NUSAP1 APC PMC10252036__F2 Various mechanisms that have been reported to regulate epithelial–mesenchymal transition (EMT) in SACC patients MYB EGF HGF NFIB APC GSK3B HEL113 CDH2 HIF1A MTOR PMC5225500__F1 Glutaminolysis in cancer cells GOT2 GPT2 MYC MTOR GLS PMC3632418__F1 mTOR as a potential treatment target for epilepsy TSC2 TSC1 PTEN EIF4E STRADA RHEB PMC4702617__F2 Deletion of the RIM15 gene on the metabolic profile of a laboratory strain during alcoholic fermentation PDC PLK1 GLG1 TK1 PMC11877449__F2 PI3K/AKT/mTOR Pathway ULK1 IGF1R EGFR RHEB PMC2349095__F2 Triggering and amplification of the Wnt/Beta-catenin pathway in osteocytes in response to load HEL-S-28 SOST LRP5 TF PMC10535221__F7 HAs induced LoVo cell apoptosis and inhibited the phosphorylation of Akt BAD BAX PMC11930217__F1 Key signal transduction processes of TGFB and Notch signaling pathways in renal cells MDM2 SMAD4 NOTCH1 CCND1 HES1 PMC12182320__F1 Expression profile analysis of key genes in the GSL biosynthesis pathway in B42OE, B42WT, and B42CR TH BMX GAL PMC7979572__F3 Stress, Nutrient and Growth factor signaling pathways that affect translation ELF2 EEF2K IGF1 EEF2 EIF4E RPS6 MTOR EIF4B PMC5002468__F1 Calcineurin/NFAT signaling pathway IGF1R NGF RYR1 RYR3 BDNF RYR2 PMC3894150__F1 Central Role of the PPARG Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition NCOR1 PCK1 DGAT2 HEL-S-104 CEBPB THRSP CEBPD NR2F2 SCD ZNF423 LEPR NCOR2 PNPLA2 FASN ADIPOR2 MID1IP1 BMP2 CEBPA ELOVL6 WNT10B LEP INSIG1 SLC2A4 MLXIPL ACLY PPARG SMAD1 CD36 PMC4938774__F7 Elevated integrin A6B4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer HEL-S-1 EGFR ALOX12 MYC DST YES1 PMP22 PRKCA MMP7 FYN ATXN1 MST1R JUNB LAMA5 LAMC2 FOSL1 HRAS CLCA2 LAMA1 YWHAQ LAMB1 CD151 MAX EIF6 HEL113 PIK3R2 PMC2533786__F9 PI 3-kinase/AKT-dependent pathways involved in IL-1 induction of IL-6 PI3 TRAF6 IRAK4 MYD88 PMC9564263__F1 Systematic Interrogation of the Temperature Perturbation in the Insulin Signaling Pathway for Optogenetic Stimulation GSK3B IRS1 INSR PMC3614492__F1 Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems CASR MCU STIM1 CALY PMC8432036__F2 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 TGFBR1 SMAD4 PMC8829728__F3 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation NLRP3 HMGB1 TLR4 LBP IL1B GSDMD PMC4973073__F4 Downregulation of PPAR pathway and bile acid biosynthesis and secretion pathway ABCC3 FACL4 AQP8 APOC3 CPT2 ABCB11 TM7SF2 HEL-S-104 CYP7A1 ACSL5 CYP27A1 ACSL1 APOA2 CYP46A1 SCARB1 EPHX1 CYP7B1 NR1C1 HSD3B7 PLTP FADS2 NR1C2 SOAT1 SLC27A5 PPARG EHHADH CD36 PMC8829728__F4 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation CD14 TLR4 LBP PMC9339684__F3 Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis STAT1 CGAS MTOR GATA4 STAT3 PMC5954621__F5 Bile acid regulation of bile acid synthesis CYP27A1 CYP8B1 CYP7B1 FGFR4 CYP7A1 PMC3243049__F3 The autophagy pathway is affected at different steps in the various types of dementias CHMP2B VCP MTOR PMC5928575__F2 Ovulatory cascade EREG COX1 TNFAIP6 AREG HAS2 PMC3893993__F3 RAS-mitogen-activated protein kinase signaling pathway GAB2 GRB2 SPRED1 SHOC2 PMC5954621__F2 Bile acid synthesis pathways CYP27A1 CYP46A1 CYP8B1 HSD3B1 CYP7A1 HSD3B7 PMC10525517__F2 RUNX1-Regulated Signaling Pathways in Ovarian Cancer TSC2 EGF EGFR MDM2 BAX PMC3888822__F2 Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways ARHA CDC42 PMC6791355__F2 Cdc37 controls a network of intracellular protein kinases ULK1 CDC37 PMC5928575__F5 PGE2 mediates early implantation CXCR4 EGFR CXCL12 PMC4702820__F4 Gene–gene network category and pharmacological category LGALS12 PECR PCCA THRSP SGPP2 PMC3947766__F1 Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time TLR7 TLR9 UNC93B1 PMC6370010__F3 Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain PAK1 LIMK1 RASGRF2 CDK5 RAC1 PMC3431702__F7 TLR signaling and proposed model for DMF-mediated impairment of DC maturation TBK1 TLR5 TLR7 TLR4 IRAK1 TRAF6 IRF3 MYD88 TLR1 TNF TLR3 PMC8446275__F1 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing RAD51 BRCA1 PMC5036051__F3 Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer MYBL2 E2F6 FOXM1 BLM EME1 MXD3 POLE2 CEBPZ TP73 PCGF6 EZH2 FANCA TF FANCF PMC6985875__F1 Mitochondrial function and localization in various lung epithelial cells during homeostasis MFN1 PINK1 MFN2 MFF DKFZp686F0183 TFAM FIS1 OPA1 PMC8037087__F2 Main mechanisms mediated by cannabinoids on angiogenesis, EMT, adhesion, invasion, and metastasis SOX2 FOS SMAD2 CXCR4 CDK4 JUNB JUN PMC5653149__F1 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer SPARC EGF HBD PMC5653149__F4 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer CD47 SRC CD36 PMC8446275__F2 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing CEP290 PMC11186432__F4 Different regulatory functions of F-box proteins in gastric cancer FOXM1 ARHA FBXO2 PTEN LATS1 VDAC3 FBXL5 FBXW7 FBXO11 FBXW5 FBXO31 CDH2 FBXO21 PMC7693799__F7 Molecular enrichment networks of genes associated with diabesity and the cluster 3 network enrichment analysis INPPL1 PRKCZ CTSS MMP9 EGFR INS IL5 IRS1 INSR RPS27A LDLR B2M SHC1 PMC5729506__F8 Schematic EGFR signaling pathway EGF MTOR PMC8071398__F2 Classic signaling pathways activated by GnRH EGF GNRHR EGFR SRC FSHB RAF1 PMC3985726__F47 Canonical (yellow background) and non-canonical (red background) Wnt/Beta-catenin signaling pathways are related to mechanical elements and actions responsible for cell polarization, migration and tissue organization APC IQGAP1 RHO PMC9243238__F2 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification RUNX2 ATF4 EIF2A XBP1 PMC9243238__F3 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification ATF4 EIF2A XBP1 PMC8432036__F5 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 TGFBR1 SMAD4 PMC9398856__F5 Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved IRS4 IGF1 TBX5 MTOR IRS1 PMC7693799__F5 Molecular enrichment networks of genes associated with diabesity and the cluster 1 network enrichment analysis TNC CSTA ALB ADA GAST CP PMC8432036__F6 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 TGFBR1 SMAD4 PMC3887408__F1 Interactions of the Ras/PI3K/PTEN/Akt/mTOR and Ras/Raf/MEK/ERK pathways with GSK-3 NF1 TSC2 ULK1 TSC1 GRB2 PTEN EIF4E RPS6 MTOR DEPTOR IRS1 RHEB PMC9656973__F7 Visfatin-Induced Inhibition of miR-1264 Facilitates PDGF-C Synthesis in Chondrosarcoma Cells and Enhances Endothelial Progenitor Cell Angiogenesis PDGFC MTOR PMC4646468__F4 Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig MAPKAPK2 COX2 BAD CASP9 SRC CDC42 PMC5379981__F6 Model whereby both uracil glycosylases and the Pms2/Mlh1 complex enable A-T base pair mutagenesis with a distinct strand bias SMUG1 TDG MSH6 MSH2 POLN UNG PMS2 PMC8674203__F2 TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers TC2N BAD ALK MYC PTEN RFWD2 PMC7348176__F7 Anticancer mechanism of HF for HCC CDK2 CCND1 CDK4 CDK6 PMC6927459__F5 Multifaceted activities of CD44v6 in PaCIC BAD HGF RUNX1 YAP1 HEL-S-28 IGF2 MMP9 TGFBR1 LRP5 CD44 LRP6 ARHA CDC37 DKK1 HIF1A GATA2 MMP14 MMP2 CXCR4 GRB2 NR1C2 CCND1 PMC7016856__F2 Anti- and pro-fibrotic roles of Epac1 in cardiac fibroblasts TGFBR1 TGFBR2 TGFB1 TF PMC2649265__F8 Insulin-PI3K-Akt signaling in AD RICTOR IGF1 PDK2 GSK3B INS MTOR COCH IRS1 PMC6927459__F7 EpCAM, claudin7 and their cooperation in PaCa EPCAM IL13 HEL-S-28 APC LRP6 TSPAN8 ARHA PTEN DKK2 PRKD1 IFNG FHL2 JUN PMC7016856__F3 Fibrotic signaling pathways by PKA and AKAPs AKAP12 ARHA ROS1 PMC6927459__F6 CXCR4 and PaCIC survival and motility CXCR4 SHH TSPAN8 BCL2 SMO RHO CDC42 PMC8127420__F4 Epidemiological link between obesity, type 2 diabetes mellitus and cancer LEF1 IGF1 GSK3B LRP5 SIRT1 PMC6865805__F2 Chronic infection of H ATG16L1 ATG12 MTOR DKFZp686F0183 PMC6627106__F4 Four branches of MOB control STRIP1 STRIP2 MOB2 RAD50 LATS1 MRE11A LATS2 PMC6624780__F9 TSL suppresses angiogenesis by inhibiting the VEGFR2 signaling pathway MMP2 MMP9 CDK4 PMC3084294__F4 The Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease CS CIT MAL PMC6539837__F1 Some common metabolic features of adult stem cells are essential for the maintenance of their quiescence, number, proliferation potential, and differentiation ability PDK2 MEIS1 MTCH2 GPX1 MPC2 HEL-S-44 PDK4 UCP2 CP HEL-S-162eP PMC6539837__F4 Intensity of information flow through the mTORC1-signaling pathway defines the fate of quiescent adult stem cells TSC1 HGF YY1 PTEN RHEB PMC8292097__F10 Carbon Monoxide-Releasing Molecule-2 Ameliorates Particulate Matter-Induced Aorta Inflammation via Toll-Like Receptor/NADPH Oxidase/ROS/NFKB/IL-6 Inhibition TLR4 VCAM1 PMC11568095__F10 Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway IGF1 MMP2 MMP9 GRB2 SOS1 PMC3585940__F5 Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver PCK1 CPT1A FBP1 PKLR GCK CPT2 ELOVL6 EHHADH NR1C1 PYGL CD36 PMC6428080__F1 Translational control mechanisms EREG ELF2 IGF1R NGF EGFR IL6 MTOR IRS1 RHEB TSC2 TSC1 IGF1 ATF4 EIF2A BDNF PMC2914056__F6 Pathway packaging of the 'biopolymer metabolic process' module PLK3 RPA1 BRIP1 MSH6 CCND1 NBN MSH2 FANCA JUN TP53BP1 PMC3488095__F8 A model for SAHA mediated effects on A1AT folding and trafficking SEL1L CANX OS9 EDEM3 PMC6680978__F4 The (a) glycolysis and (b) PKA-AMPK pathway genes and metabolites modulated by dietary BRBs during oral carcinogenesis PDE4A SMAD4 PFKL HEL-S-87p PIK3C2G HEL-S-49 ELAVL1 CREBBP PDE10A ENO2 YWHAG PGAM2 HK2 PMC6052044__F1 Metabolic pathway reconstruction for Spirochaetes in hydrocarbon- and organohalide-contaminated environments F2 F5 F3 PMC4970823__F2 Regulation of cancer cell functions by hyaluronan (HA)‐receptor interactions PATJ CD44 RHO EPHA2 PMC8395015__F1 Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers HEL-S-277 ARG2 NOS2 ARG1 ASS1 ASL PMC3887408__F5 Novel approaches of targeting signaling pathways in leukemia CCND1 ATF5 MTOR SIRT1 STAT3 PMC3283951__F5 The acetate/mevalonate pathway for the formation of IPP, the basic five-carbon unit of terpenoid biosynthesis CS HCCS IPP PMC6834135__F1 NK cell features in chronic HBV infection CD44 KLRG1 IFNG PMC8570953__F1 Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway JAK1 FADD BAX PMC5331729__F2 LncRNAs network in malignant transformation of HCC stem cells IL18 CDK2 CTCF POLL IL6 PTEN SETD2 PCNA SKP2 CCND2 TERT POLI PMC5331729__F4 Roles of LncRNAs in the malignant transformation of breast CSCs SOX2 HOXD10 SETDB1 STAT3 PMC8715196__F13 KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway PMC5988573__F1 Schematic diagram showing the positive feedback loop between Hippo-YAP/TAZ and IRS2-AKT signaling in the DKO livers APC PTEN PMC4008004__F1 Hyperglycemia alters the expression of multiple genes of the transforming growth factor‐B (TGF‐B) pathway through the polyol pathway in retinal vessels ELK3 COX1 TIMP1 BMPR1A HOXC8 TGFBR1 CD44 NOTCH1 SOAT1 IFNGR2 TXNIP MXI1 PMC7867545__F10 The Impact of the CMT2B-causing RAB7 mutant protein on the endocytic pathway TSG101 CTSL LAMP2 HEL-S-130P PMC12153797__F2 Core signaling networks that contribute to the development of vasculogenic mimicry ATM CDK2 PMC12153797__F1 Exploration of the VE-cadherin structure and the transformations it undergoes when it comes into contact with VEGF-A CSK SRC PMC6547810__F8 Schematic drawing of the suggested intracellular signaling pathways of LIF and OSM receptors in osteoblasts mediating expression of osteoclastogenic factors, osteoclast formation and bone resorption LIF GRB2 JAK1 OSM SHC1 OSMR STAT3 PMC12153797__F4 Pathways in immune cells that short-chain fatty acids generated by GM triggers SNAI1 CD44 SOX4 CD24 PMC12153797__F3 Correlations of microbiome and different cancers FUT8 TLR4 CD44 STAT3 PMC8019825__F8 Summary of the pathological alterations of CRS-3 SHC2 GRB2 MTOR PMC7108978__F2 Simultaneous utilization of 2H and 13C tracers provides insights into distinct pathways of hepatic metabolism HEL-S-62p CIT MAL PMC10740933__F3 (Left) Initial biosynthetic pathway for the formation of a lipofuscin fluorophore A2E in photoreceptor outer segment (OS) and its structure as a component of lipofuscin (LF) in the RPE cell ATR RPE PMC9616778__F8 Cilostazol Alleviates NLRP3 Inflammasome–Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories NLRP3 GFAP TRPA1 BDNF SIRT1 PMC9304404__F7 Mechanistic diagram of apatinib in NSCLC cells ATF4 ASNS PMC3096649__F7 IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis IGF1R IGF1 GRB2 SHE IRS1 PMC2805793__F1 Ligand binding and subsequent Erbb dimer formation initiates signaling through a complex array of intracellular pathways that initiate and control a range of cellular processes BAD ERBB2 ERBB3 GSK3B GRB2 PTEN MTOR PMC7645337__F7 Core molecular net words identified by IPA EPO HNF4A CTSA HIF1A HMOX1 JUN HK2 PMC4386979__F2 Intracellular signal paths coupled to the opioid receptors and implicated in cardiac stress signalling and cardioprotection EGF EGFR MTOR STAT3 PMC10568034__F2 Manner in which the studied product acts on the Wnt pathway in lung cancer APC TF PMC3320915__F7 Model of proposed CCR7/CCL19 signaling pathway in T cells CCR7 CCL19 KLF2 PMC9690286__F1 Small Non-Coding RNAs in Human Cancer DROSHA RAN PMC7690430__F3 Targeting the PI3K–AKT–mTOR pathway to treat prostate cancer TSC2 TSC1 PTEN PMC4448502__F4 Pathway analysis showed a strong role for early response genes and sterol regulatory elements PTMS EGR1 KRT34 HEL-S-116 UCP2 LIPE ZFP36 EGR2 REEP2 PIM3 SREBF2 VWF JUND ACLY MYLK PMC5573409__F4 Diagram of P53 signaling pathway with overlaid molecular activity prediction after heat stress PML PMC4021040__F2 Targeting glioma stem cells: a novel framework for brain tumors EGF EGFR PTEN PMC8945343__F5 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies NPS PGC TXNIP PMC8197763__F8 Action mechanism of H2A.Z in HCC TCF3 JUP IGF1 CDKN1A CDK14 SPINT1 BCL6 PMC8945343__F4 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies MFN1 MFN2 BNIP3 UCP2 OPA1 PMC6056717__F1 Coenzyme Q10 deficiencies: pathways in yeast and humans FDX1 COQ3 FDX2 COQ2 COQ6 ALDH3A1 COG6 COG5 PAH IPP COQ7 FDXR PMC12177077__F5 MBD2 in autoimmune diseases MBD3 STAT1 MBD2 IFI35 PMC5436564__F6 Working model of E2-activated SGK1 involvement in negative regulation of TLR-4-mediated apoptosis and pro-inflammatory TH1 immune responses at the feto-maternal interface TLR4 BCL2 IRF4 SGK1 FOXO1 PRL PMC6721316__F1 Protein functional interactome network for differentially expressed proteins identified in Pancreatic ductal adenocarcinoma (PDAC) tissue; down-regulated proteins (A) and up-regulated proteins (B) RPLP0 CTRC PLEC STOM TES TBCA DES PSAP AHNAK RPSA PRELP HLA-C ARPC4 SND1 HEL-S-111 HEL107 HEL-S-20 APOE PMC6779857__F1 The core components of the Hippo signaling pathway LATS1 LATS2 PMC4956504__F1 Androgen pathway and genes involved in androgen biosynthesis and metabolism HSD3B1 HSD17B2 HSD17B3 PMC4907806__F3 Exercise-Driven Metabolic Pathways in Healthy Cartilage BAD TEC HEL-S-69p PMC9040077__F1 Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease TRADD FADD IFNG PMC8451139__F8 New Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling MFN2 BAD FADD BAX PMC6776190__F9 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs E2F4 SMAD2 SMURF2 TGFBR1 SMAD6 SMAD4 SKP1 THBS1 SP1 RBX1 SMURF1 SMAD1 PMC11354542__F6 Neurotrophin-signaling pathways in the high-intensity exercise group (blue: downregulation) DAO SHE PMC6776190__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs APC LRP5 LRP6 PMC11783322__F6 Protein-protein interaction (PPI) analysis (A) PPI network analyzed through STRING web site (www HEL-68 MAPK3 MAPK14 ARHA WAS NCK1 PMC9204593__F2 Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure HEL-S-11 PGC CNP PMC6357062__F1 Intracellular negative immune regulators of dendritic cells (DCs) SOCS3 FOXO3A RELA SOCS1 STAT3 PMC5564223__F1 The influence of Notch and Wnt pathways in the oncogenesis and stemness maintenance of breast cancer cells in the absence of estrogen NUMB CCND1 FOXA2 PMC4957033__F5 Top network of THC-regulated miRNAs SOCS2 NFATC2 SMAD2 KLF4 SSB CDK4 TNFSF12 BDNF CDKN2A IRF4 BRCA1 CCNE1 PMC11173095__F3 VEGF signaling pathway FRK FRS2 GSK3B GRB2 SRC SHB MTOR PMC4762491__F2 Man-P-Dol acts as mannosyl donor for the synthesis of M9-DLO, GPI anchors, and C- and O-mannosylated proteins DPM1 ALG3 SRD5A3 DPM2 DPM3 PMC4795779__F1 Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration ATF4 EIF2A XBP1 PMC2958833__F2 Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus TSC2 RICTOR TSC1 GSK3B GRB2 RORA BDNF NR1C1 RHEB RXRA PMC8919014__F3 Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives APC MYC AXIN1 STAT3 PMC5337497__F3 Schematic presentation of the tricarboxylic acid cycle (TCA) pathway and amino acid biosynthesis, as affected by the chlorotic mutation CS DLD ACLY CIT NAGS DLAT ASL PMC6397842__F2 Schematic overview of bone cells and extracellular matrix components involved in regulating bone homeostasis SPARC SOST DKK1 PMC3894810__F5 New insights into host–pathogen interactions during Entamoeba histolytica liver infection CP PMC6366073__F5 Euglena gracilis has flexible and fault-tolerant mitochondrial metabolism AFP FES ISCU PMC2671802__F1 ALPS and CEDS illustrate signaling pathways for lymphocyte apoptosis and activation BCL10 NRAS FADD PMC6046065__F1 Pharmacological modulation of mitochondrial calcium homeostasis EFHA1 MICU1 DLD MCUB MCU PMC5247608__F7 Model depicting roles of Sufu in chaperoning Gli functions during Shh signaling SAP18 KIF7 SUFU PTCH1 GLI3 SHH SMO SIN3A PMC8034539__F1 B3-adrenergic signaling pathway that promotes thermogenesis in adipocytes NRF1 UCP1 IRF4 TFAM PMC9251357__F2 Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites NLRP3 IL1B GSDMD NINJ1 PMC8034539__F2 Schematic models of BMP7 and TGFB signaling pathways in thermogenesis COX2 SMAD2 BMP7 WNT10A SMAD1 DKFZp781O1323 PMC3950821__F3 Leveraging melanocortin pathways to treat glomerular diseases GSK3B SRC RHO IL1B CDC42 PMC3091524__F3 Role of ATR- or ATM-dependent modulation of WRN function in promoting correct recovery from replication arrest ATM TOPBP1 ATRIP RAD51 ATR WRN PMC2169053__F6 Model for SCF-mediated regulation of hFBH1 and Srs2 turnover in response to DNA damage FBXO18 SKP1 RAD18 PCNA PMC9277879__F2 Gut–liver axis in sepsis: interaction mechanisms and therapeutic potential TLR4 LBP IL6 MYD88 PMC3372318__F3 The two major signaling cascades operating in cancer, following overactivation of the INSR/IGF-IR signaling pathways MTOR RHEB INSR PMC9110832__F1 Involvement of Caspases in Neuroinflammation and Neuronal Apoptosis in Chronic Pain and Potential Therapeutic Targets CXCR3 CCL21 TNF IL1B TRPV1 PMC6558407__F5 Insulin and autophagy signaling modulation in Huntington’s disease (HD) IGF1 ATG12 DKFZp686F0183 IRS1 PMC7144527__F8 Schematic model for RNF125 and Cbl-b in LPS-induced endotoxemia NLRP3 TLR4 MYD88 IL1B CASP5 GSDMD RNF125 CASP4 PMC3638063__F1 MTOR signaling pathway TSC2 RICTOR TSC1 PTEN EIF4E GRB10 MTOR DEPTOR SGK1 RHEB MLST8 PMC7046304__F8 SPAG5‐AS1/miR‐769‐5p/YY1‐positive feedback loop transcriptionally induced SPAG5 and SPAG5‐AS1 interacted with USP14 to induce de‐ubiquitination of SPAG5, so that AKT/mTOR signalling was activated to inhibit autophagy and induce apoptosis in podocytes USP14 YY1 MTOR SPAG5 PMC4971466__F4 Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala) SMURF2 SMAD4 SKP1 ARHA SMURF1 SMAD1 IFNG PMC8460909__F7 Myeloid-Derived Suppressor Cells Alleviate Renal Fibrosis Progression via Regulation of CCL5-CCR5 Axis CCR5 SMAD2 CCL5 PMC7959294__F10 Schematic diagram illustrating the potential targets of HSR2104 to inhibit inflammatory responses and cell migration in BV2 cells TLR4 MYD88 PMC8964740__F2 Main mechanisms of miR-31 in oral squamous cell carcinoma (OSCC) NUMB EGFR ARHA LATS2 WLS SIRT3 PMC8215340__F1 Metformin, Macrophage Dysfunction and Atherosclerosis NLRP3 TLR4 ACAT1 ABCG1 CCR7 CCL5 CCL2 ABCA1 UNC5B TNF NCEH1 CD36 PMC6719526__F4 Metabolic reconstruction of the isolated strains Halonotius terrestris sp COBL RFWD2 PMC5766142__F6 Methylene-tetrahydrofolate reductase contributes to allergic airway disease OPRM1 RNF31 MLF2 MYL10 RPL13 OSBP EPHB6 STAC3 MC4R GPR132 STAG3 MAPK11 IL9R ASB4 NFKBIE TRIO PMC6558407__F2 PI3K-AKT-mTOR signaling and Metformin targets TSC2 TSC1 IGF1 IRS1 RHEB PMC9665039__F3 Signalling by TNFR1 and overview of the three characterized cell death checkpoints in the TNFR1 pathway RIPK1 TANK TRADD SHARPIN RIPK3 TNF FADD MLKL GSDMD PMC7583940__F1 Canonical pathway of microRNA (miRNA) biogenesis AGO1 AGO2 DGCR8 AGO4 DROSHA PMC8985609__F2 Activation of the non-canonical NLRP3 inflammasome NLRP3 TLR4 IL1B PMC9735758__F3 IL-1RAP, a Key Therapeutic Target in Cancer IRAK1 IL36A IRAK2 IL36B TRAF6 IRAK4 MYD88 MAP3K7IP1 PDPK1 GAB2 IL33 IL1B TAB3 PMC7923182__F11 Scheme of reactions proposed for Rho pathway modelling DAAM1 ARHA WNT5B PMC8466454__F7 Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling MAF KEAP1 GPR49 PMC6944231__F5 Presynaptic proteins that were altered in AD PCLO FYN VAMP2 UNC13C CLTC NAPA PMC5360511__F5 PPARG targeted oral cancer treatment and additional utility of genomics analytic techniques FLI1 GP9 MADD CAV2 CD36 CD24 PMC6944231__F3 Pathway analyses of significantly altered proteins by IPA CHGB KEAP1 NFE2L2 RALA SNAP25 KCNA2 SNAP29 SYT1 RAB3D GNG3 VAMP2 SLC12A2 FARP1 GNAI3 VSNL1 GNAO1 RIMS3 DCTN3 PMC4148307__F8 Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation GNA11 MTOR PMC11106741__F2 Esc, a compound with potential anticancer properties, promotes apoptosis and inhibits the proliferation of tumor cells IGF1 KEAP1 CCND1 JAK1 SP1 MTOR STAT3 PMC11106741__F1 Esc in cancer cells was revealed to be related to apoptosis, which is governed by the mitochondrial pathway, ER stress and ferritinophagy GPX4 SP2 FTH1 NFE2L2 SP1 XBP1 PMC3891875__F1 Wnt signaling NLK RUNX2 APC LRP5 LRP6 RHO PMC6471465__F6 Signaling pathway involved in intact or papain-hydrolyzed glycomacropeptide modulation on RAW 264.7 macrophage response to lipopolysaccharide or hydrogen peroxide TLR4 KEAP1 MYD88 PMC7017369__F7 Signaling cascades of RA-mediated repression of B3GALT5-LTR promoter activity that reduce SSEA3 synthesis in human ES cells SIRT1 STAT3 B3GALT5 PMC8415231__F2 Targeting the Wnt/Beta-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis MAF APC SFRP1 DKK1 WIF1 PMC2833197__F7 Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway ATF4 VEGFA XBP1 PMC2579774__F4 HIV-1 infected astrocytes and the microglial proteome RPLP2 PIG59 EGR1 GM2A ZNF148 CNBP ENO1 PMC8124582__F2 Posttranslational Modification of Waxy to Genetically Improve Starch Quality in Rice Grain PGM2 FBP1 UTP4 PMC548008__F7 The molecular mechanisms involved in the TGF-Beta-Smad7 signaling pathway resulting in activation of Akt and p38, followed by phosphorylation and inactivation of GSK-3B GSK3B PMC4684418__F1 Targeting Pink1-Parkin-Mediated Mitophagy for Treating Liver Injury PINK1 USP15 SIAH3 BAG4 USP30 PMC7353140__F1 Features of the nuclear envelope and ER and regulation of and functions for lipid asymmetry at the inner nuclear membrane (INM) PC NUP133 CTDNEP1 PMC8524782__F2 Molecular Mechanisms of Hepatoblastoma PIG59 HGF APC GSK3B AXIN1 LRP5 LECT2 GPR49 GREB1 PMC8240219__F9 Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway MAF KEAP1 MLKL PMC8348825__F1 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta LEP IGF1R GRB2 INS TBC1D4 IRS1 IL1B PMC2699361__F1 The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX BAD TRAF2 BAX PMC8348825__F2 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta TG PRL BCL6 PMC4236175__F1 Examining the Polymorphisms in the Hypoxia Pathway Genes in Relation to Outcome in Colorectal Cancer HIF3A CXCL12 HIF1A PMC6801506__F3 The most significant Ingenuity Pathway Analysis (IPA) network of differentially regulated proteins in the MHO group compared to those from the MUHO group ANAPC7 NRAS UNK AMBP KRT10 PMC9279723__F1 Autophagy in Bone Remodeling: A Regulator of Oxidative Stress TFEB FOXO3A MTOR PMC3789264__F8 Brain site-specific proteome changes in aging-related dementia UBC CEND1 GSK3B CDK5 APP TNR AHNAK GNB1 CLU PMC3049118__F3 Endocrine system development and function genes increase in the spleen of CVB3 infected males at 12 h pi DNAJB4 DNAJA4 BIRC5 MSR1 STK11 TCF7L2 SPARCL1 FKBP4 CHEK1 HTRA2 PMC2902124__F1 TLR signalling TLR8 TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 MYD88 TLR3 PMC3789264__F7 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) cerebellum (Cb) ZFYVE28 ACOT7 TUBB MBP SLC18A3 SCAMP3 AHNAK HEL113 SPCS2 PXK CCDC50 HEL-S-162eP PMC3789264__F6 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) parietal cortex (pCx) ATPAF1 EP300 HMGN5 MSTO1 SCRN1 ZNF358 TMEM131 ANXA6 HEL113 PMC3169997__F1 Epithelial cell cycle arrest in G2/M and epigenetic changes in fibroblasts coordinately promote kidney fibrosis ADA RASAL1 PMC3789264__F5 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) hippocampus (Hp) INA MARCKS TMCO3 MBP ALB CEND1 AHNAK HEL-S-162eP PMC3277752__F2 Browsing the ApoptoProteomics database BAD FADD PMC9148284__F1 Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology KEAP1 EIF2A HTRA2 BAX PMC8509056__F6 Molecular and Metabolic Insights into Anthocyanin Biosynthesis for Leaf Color Change in Chokecherry (Padus virginiana) MYB MAX PRL PMC8387351__F1 Stress response pathways dysregulated with age and injury: ATF4 PMC5177517__F6 Proposed model for the mechanism of SNRK regulation of ROCK activity SNRK RHO PTEN PMC3049118__F6 Cardiovascular disease genes increase in the spleen of CVB3 infected males at 12 h pi PLA2G12A HEL-S-11 NCKAP1 LPL CCR4 CA3 BAG2 MAP2K3 CXCL12 HPR FRZB PMC2654353__F5 From nutrients to HIF and from HIF to metabolism TSC2 TSC1 MTOR HEL-S-133P HK2 HEL-S-68p PMC2654353__F7 From the extracellular matrix to HIF and from HIF to the extracellular matrix LOXL2 CXCR4 MTOR PMC5007661__F3 Potential impact of bone tissue engineering in the clinic SUN1 BAD FOS APC SRC BAX PMC3229969__F2 Roles of FGF signaling in stem cell self-renewal, senescence and aging FRS2 MDM2 GRB2 PMC4490940__F10 Possible pathways of Cd-induced MAPK/ERK signaling GAB2 CD2 EGFR GRB2 SRC HBEGF PMC1991338__F1 ZIP1 expression and zinc accumulation in the pathway and bioenergetics of citrate production and citrate oxidation in normal versus malignant prostate cells CS CIT MAL PMC7019052__F3 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on the p38 MAPK signaling TRADD MAPK14 RPS6KA5 RAC1 MAP2K6 DDIT3 MEF2D HEL-S-102 STAT1 RIPK1 GRB2 HMGN1 TRAF2 SHC1 PMC4628569__F3 IL-27-induced modulation of autoimmunity and its therapeutic potential IL10 STAT1 SOCS3 AHR EGR2 TYK2 JAK1 GATA3 STAT3 FOXP3 PMC4706927__F5 Putative inhibitory pathway of macrophage-mediated inflammatory signaling responses, as suppressed by KTH-13-AD1 TLR4 SRC MYD88 PMC7602422__F1 Aryl-hydrocarbon Receptor (AhR) Signaling Pathway in Osteoclasts AHR NFATC1 SYK CYP1A2 PMC7757040__F2 Diagrammatic illustration of the mechanism by H2S donors in regulating autophagy and cell migration LIMK1 TIMP3 CDH2 SP1 MTOR DKFZp686F0183 PMC6697704__F1 Main molecular interactions implemented in the model HGF PMC3987972__F3 Intracellular signalling pathways mediated by HLA class I or II antibody binding to endothelial cells NUP153 EIF4A1 IFNE DDX3X RHO TG PMC7019052__F4 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on IL-1 signaling PIK3R1 PLCG1 PRKCZ CHUK MAP2K4 ATF2 TRAF6 IRAK4 MYD88 MAP2K3 MAP2K6 UBE2V1 PTPN11 ECSIT JUN IL1B MAP3K1 HSPB2 MAP2K2 PELI1 IKBKB NFKBIB MAP3K2 NFKB1 MAP3K14 REL PIK3R2 TAB3 PMC6965011__F2 Proposed model depicting regulation and role of METTL3 and FTO in BMSC adipogenesis and osteogenesis with regard to osteoporosis PTH1R RUNX2 PTH JAK1 GDF11 HEL-S-104 PPARG PMC5335607__F3 Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons PC CD44 ARHA POR TF PMC7278761__F3 Schematic presentation of interactions between nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NFKB) transcription factors TH IL6 PMC7433199__F3 Signaling pathways other mucins involved in non-small cell lung cancer PRDM16 MUC4 MMP2 MUC5AC MMP9 EGFR GSK3B CCND1 SPDEF MUC2 PCNA STAT3 PMC6386916__F7 EtOAc extract of L DCT MC1R PMC6958341__F5 Overview of the metabolic pathway changes in murine 3T3-L1 adipocytes due to insulin or TNFA treatments ROMO1 COX7A1 COX2 LIPE UQCRB NDUFAF2 NDUFB10 HEL-S-44 COXFA4 HSPD1 NDUFS8 HEL-S-5 PMC3357552__F7 TLR4 signaling in alcoholic steatohepatitis and fibrosis TLR4 SMAD2 TGFBR1 IRF3 CCL5 CCL4 MYD88 COL1A1 TGFB1 TLR3 IFNG CCL3 PMC8851315__F1 Mitochondrial-Derived Peptides in Diabetes and Its Complications CNTFR STAT3 BAX PMC11392669__F10 Tumoral VISTA facilitation of the proliferation of CML cells and suppression of apoptosis BAD GAB2 GRB2 BCL2 MTOR CRK CRKL PMC8195260__F2 Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease BAD RHO EIF4E MTOR RHEB INSR TSC2 TSC1 PLD2 ELF3 EIF4B PXN STAT3 PMC4077663__F2 Leptin–brain melanocortin system interaction INA POMC MC4R PMC3164457__F5 Mi-2/NuRD complex depletion in germinal center B cells leads to alterations in chromatin, checkpoint activation, and delayed progression through S phase ATM SETDB1 CDK2 CCNB1 RAD51 CHD4 CDC45 PMC5727169__F5 Pathway analysis using WikiPathways revealed that the factors related to the calcium signalling pathway (Kelder, T., Chichester, C., Hanspers, K.: Calcium Regulation in the Cardiac Cell (Danio rerio) PKIG RGS4 RGS1 ADRB2 SPN HEL-S-93 YWHAG PMC3357552__F1 Overview of TLR signaling TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC2955995__F1 Targeting Notch signaling pathway to overcome drug-resistance for cancer therapy NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC5544253__F4 BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure RELA HEL-S-273 B3GALT2 LITAF Nucb2 JUN TGFB1 PHGDH ACKR2 CEBPB GPR64 BAX PMC6582499__F8 Schematic diagram illustrate the potential mechanisms of VPA and gemcitabine on pancreatic cancer cells GEM BMI1 STAT3 PMC10883245__F8 DOCK7 in EVs mediates intercellular communication between TAMs and CRC cells ABCA1 FOXO1 DOCK7 PMC6814379__F1 Glucose metabolism, energy production, and its importance in DNA replication and epigenetic homeostasis GC PSPH PHGDH PMC4806302__F6 Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway SAG SHH SMO PMC11642109__F1 Schematic illustration showing the effects of the sympathetic nervous system (SNS) and the renin–angiotensin system (RAS) on cancer development RAP1A MTOR ACE2 STAT3 GATA1 PMC8391894__F2 DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity POLE RAD51 DNA2 BRCA1 PMC5689469__F6 Proposed mechanism of muscle immaturity in CDM CTCF DMPK STAT3 PMC2756021__F3 Neuroprotective Effects of the Complement Terminal Pathway During Demyelination: Implications for Oligodendrocyte Survival BAD BAX PMC5995803__F8 Multiscale networks identified within neurons contain neuron-specific modules GOLGA7 COX7A2L DNAJC18 FAXC CNIH CLCC1 BLOC1S2 BRD10 DENND4A GSK3B ALDH3A2 MRPL22 NAPB NR2F1 RPL19 USP24 PDPK1 POLR3E NF1 GGA2 BMPR2 PPP1R9A LDOC1 ZNF385B ACVR2A PTBP3 KIDINS220 HLF CAPZA2 NDUFS4 PHF10 SH3GLB1 EPHA7 FGF13 SLC2A13 STAG2 SMDT1 SPTBN4 KMT2C DPM1 MEGF9 LRP11 ZNFX1 BRD2 RBM23 ZRANB2 DNER PRKCE ARHGEF12 CRIM1 sm-M20 SSU72 PFDN4 IPO5 MTOR SYNGR3 CMPK1 DIS3L2 SRSF4 EEF1B2 NME4 RPS6 SAT2 NFIA RNF115 RPLP0 SRP14 DKK3 HECW2 KIF3A WASF3 RAC1 MRPS28 BCL6 TMEM130 CD59 OSBPL6 NFKBIA NDUFA2 GRIK1 IL6ST TMEM151A BICD1 C1orf52 AASDHPPT TBC1D30 ASB8 KPNA6 IFT81 BAALC MCF2L2 PMC7172983__F1 CGAS-STING pathway of cytosolic DNA sensing TBK1 STAT1 CGAS ULK1 STAT2 WIPI2 IRF3 TYK2 JAK1 ATG9A NLRC3 PMC8058381__F7 Fubaiju protected ARPE-19 cells oxidative damage by activating PI3K/Akt mediated Nrf2/HO-1 signaling pathway GCLC NQO1 BAX PMC3524627__F8 Model depicting the regulation of DNA damage-induced germ cell apoptosis by C SGK1 PMC9448988__F2 Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy EGFR CXCL8 TNF IFNG PMC8692584__F1 E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe? CAP1 TRIM21 RELB IRF3 MYD88 RIPK2 TNF RNF183 MAP3K7IP1 NOD2 CAP2 RIPK1 USP16 TLR4 NOD1 CYLD TRIM58 RELA USP9X TRIM28 REL TRAF2 LTBR TAB3 PMC10178682__F1 Simplified picture of cancer metabolism SLC7A5 CS GOT2 GPT2 FH HK2 GLS PMC8741373__F11 Identification of Potential Biomarkers of Depression and Network Pharmacology Approach to Investigate the Mechanism of Key Genes and Therapeutic Traditional Chinese Medicine in the Treatment of Depression TRAF3 MGA PMC10094755__F6 Metabolic pathway of 17Beta-estradiol biosynthesis HSD3B1 CYP11A1 HSD3B2 HSD17B1 HSD17B2 STAR PMC10539668__F8 TNFA counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes SOCS3 LYN TYK2 JAK1 STAT3 PMC9331798__F7 Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage TNFSF11 MTOR IL1B PMC5689582__F3 Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer SQLE CYP2R1 DHCR7 EBP FDFT1 SC5D DHCR24 CYP24A1 SOAT1 TM7SF2 CYP51A1 MSMO1 PMC11833111__F5 Correlation analysis of differential microbiota, metabolites, proteins and FST FST ENPP2 PNPLA7 LPCAT1 PMC8535226__F2 Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease BAMBI E2F4 NODAL ROCK1 PITX2 SMAD2 TGFBR1 SMAD6 SMAD4 SKP1 ARHA RBX1 SMURF1 LTBP1 IFNG FST SMURF2 THBS1 SP1 SMAD1 DKFZp781O1323 PMC7830467__F1 Ubiquitin signaling in the tumor microenvironment (TME) MMP2 PMC4472614__F4 Functional relations of differentially expressed genes with each other and with members of important pathways, as displayed by FunCoup online resource DAG1 HELLS FER AKAP12 JUP FOS NR1C2 RCC2 SPN LMNA NKTR EMP1 PMC4451739__F2 Complement during infection with a pathogen HEL-S-62p C9 C4B_2 C7 C6 PMC3042730__F2 Inflammatory signals regulate hematopoietic stem cells TRADD STAT2 IRF9 ATF2 TRAF6 IFNGR2 IFNAR2 MYD88 IFNAR1 IFNG STAT1 TYK2 CSA2 JAK1 IFNGR1 TRAF2 PMC11885647__F6 Stem cell exhaustion and intercellular communication regulated by redox signaling FYN KEAP1 AMOT NF2 SMAD2 PTCH1 SMAD4 SHH SMO LATS1 RHO PMC11885647__F5 Redox signaling modulates metabolic reprogramming TSC1 EFHA1 MICU1 MCU PTEN IRS1 PMC11885647__F4 Redox regulation of proteolysis PTMS ATE1 FAT10 PMC4793894__F3 PPAR signaling pathway OLR1 UCP1 PCK1 PLIN1 APOC3 CPT2 HEL-S-104 CYP7A1 PDPK1 ACOX1 UBC CYP27A1 CYP8B1 AQP7 SCD LPL APOA5 ACSL1 NR1H3 APOA2 ME1 SLC27A4 ANGPTL4 HEL-S-28 NR1C1 RXRA DBI PLTP FADS2 ACADL NR1C2 SLC27A5 PPARG ACADM CD36 FABP1 PMC7037237__F1 Simplified schematic of type-I IFN induction and major IFNAR signaling pathways CGAS TLR9 IRF7 IRF9 IRAK4 IRF3 IFNAR2 MYD88 TNF IFNAR1 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 IRF-1 PMC6814307__F1 Vitamin D metabolic pathway FGF23 CYP2R1 CYP24A1 PTH CYP27B1 PMC8635790__F5 Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease ACSL6 FACL4 SEPHS2 FTL SLC40A1 SLC11A2 PMC3481284__F8 Schematic diagram of CaMKII regulates Notch1 signaling through proteasomal degradation of SMRT HES5 NOTCH1 HES1 PMC6953115__F2 Epac1 signalosome in cardiac stress conditions TRPC3 HDAC5 PMC6780103__F4 Human adenovirus induced cell signaling and downstream immune responses in human keratocytes, highlighting the centrality of Src kinase TLR9 CD46 SRC MYD88 TLR1 PMC3230686__F3 Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27 MAF STAT1 RORC AHR RUNX1 STAT3 FOXP3 PMC5927979__F2 Interaction network of microRNAs identified potential mRNA targets involved in clinical features of antiphospholipid syndrome CD47 SBF2 LAMP2 VEGFA SAMD12 NNT CCL2 PARVA E2F3 INSR HIVEP1 ANKRD29 BMPR2 BPTF EDNRB DGKE DOCK4 NR1C2 SCNN1G RASL12 AXL PTPRM PMC8825490__F1 Macrophage Immunometabolism: A New Approach to Fight Infections HEL-S-30 FH ACO2 OGDH SLC3A2 HEL-S-133P HEL-S-68p HEL-S-162eP PMC8245300__F5 ATRX-dependent mechanisms in physiology, cancer and human genetic disease REST PMC4225461__F1 Statistically significant signaling pathway networks between JU and vehicle groups RORC ANGPTL3 DUSP4 PTGFR WRNIP1 ANXA3 SPRED1 APBA3 ATF3 CYB CGA DNAJC2 AGTR2 CEACAM1 RNASEL HCST AMH CCNG1 FOSB PSENEN SERPINB2 CP APH1B PMC8216565__F8 PI3K-AKT signaling pathway TSC2 BAD MEI1 MDM2 GRB2 SYK PTEN REL EIF4B RBL2 RHEB CD19 PMC4424001__F2 Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks PLCB3 EGFR SHE PMC8216565__F9 MAPK signaling pathway CD14 NLK MAX FLNA PROC APP TRAF2 APMAP ELL PMC3879958__F1 Regulating the Regulator: Post-Translational Modification of Ras TIAM1 NF1 RIN1 RAF1 PMC2671025__F6 Role of adiponectin in human skeletal muscle bioenergetics ADIPOR1 ADIPOR2 MEF2C PMC4023229__F2 Neural tube defects – recent advances, unsolved questions and controversies SMURF2 PTK7 SFRP1 ARHA VANGL1 SMURF1 SFRP5 CTHRC1 PMC11375541__F10 Dual functionality of necroptosis in CC patients CXCL13 CD3D CXCL10 VEGFA CXCL9 CXCL11 PMC2696553__F1 Store-operated Ca2+ entry in T cells LCK ORAI1 LAT FOXP3 PMC7411728__F2 Inflammation, innate immunity, and adaptive immunity by CH25H and 25HC CH25H IL18 TNF IL1B PMC8650046__F3 Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator PIK3R1 PLCG1 EGFR PFKFB4 IFNGR2 TFRC HIF1A HMOX1 INSR PRKCA FLT1 TLR4 MAPK1 IFNGR1 HEL-S-133P HK2 ANGPT2 CDKN1B VHL VEGFA EIF4E IL6 HEL-S-87p PIK3R3 HEL-S-68p EGLN3 CREBBP EP300 TIMP1 CDKN1A NFKB1 RPS6KB2 RELA BCL2 AKT3 STAT3 PMC9099016__F3 LncRNAs and CircRNAs in cancer FOXP2 CCND2 PMC6678715__F3 FGFR signaling pathway FRS2 GRB2 DOCK1 CRK PMC2910728__F6 Absence of Inhibin Alpha and Retinoblastoma Protein Leads to Early Sertoli Cell Dysfunction ACVR1 APAF1 BBC3 CCND1 CDK4 FSHR CDKN2A CCND2 PMC7538694__F7 BMP signaling pathway in mouse and zebrafish SMAD4 ID1 SMAD1 DKFZp781O1323 PMC7145763__F5 Human BNB junction complex formation: The GDNF-CREB1-SRC-CTTN/CTNNA1/CLDN4-SEC31A hypothesis RET SEC31A CREB1 GDNF SRC CTNNA1 CLDN4 PMC9101234__F6 Cardiac Fibroblast GLS1 Expression by Scleraxis GPT GLS PMC8584118__F2A Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections IRAK1 NLRP12 TRAF3 RELB TRAF6 MYD88 PMC9299562__F3 Integrated bioinformatics analysis of validated and circulating miRNAs in ovarian cancer DES POR PMC4899597__F1 Canonical Wnt signalling involves binding of Wnt to LRP5/6 and its coreceptor Frizzled resulting in the phosphorylation of LRP5/6 thus permitting Axin to bind to the receptor complex TEF LRP5 LRP6 PMC8013908__F1 COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options TBK1 CTSL IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 TLR7 TLR4 NRP1 HDAC2 FURIN ACE2 IL1B TMPRSS2 PMC3774073__F1 Phosphorylation events and the modulation of aquaporin 2 cell surface expression GC AQP2 SNAP23 MAL PMC9405025__F3 Yeast Beta-Glucans as Fish Immunomodulators: A Review APOA4 SYK MYD88 IL1B PS1TP5BP1 PMC2981507__F2 Therapeutic interventions for fragile X syndrome TSC2 TSC1 EIF4E MTOR RHEB PMC3176306__F1 New strategies in Prostate Cancer: targeting lipogenic pathways and the energy sensor AMPK TSC2 TSC1 EIF4E ACLY MTOR RHEB FASN HEL-S-5 PMC3075259__F4 Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants MTR DKFZp781B1423 CCNB1 MDM2 CDKN2A PMC8497523__F7 Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways PDE4D NUDT5 AMPD3 PFAS PGM2 PAICS IMPDH2 NME3 CMPK1 ADK PMC5569249__F1 miRNA pathways in myeloid differentiation and myeloid-derived malignancies TPO PTEN BTG2 MTOR PMC5660697__F1 JNK signaling pathway TH HMGB1 ATF2 PMC5082882__F1 Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERA in Breast Cancer Cells FADS2 ELOVL5 FADS1 ELOVL2 PMC5569249__F2 miRNA pathways in mature immune cell function IRAK1 IRAK2 MYD88 IL1B SOCS1 PMC9139060__F2 Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention NLRP3 HMGB1 FLI1 TRAF6 MYD88 PMC9124082__F7 Marine-Derived Stichloroside C2 Inhibits Epithelial–Mesenchymal Transition and Induces Apoptosis through the Mitogen-Activated Protein Kinase Signalling Pathway in Triple-Negative Breast Cancer Cells CDK2 CCNB1 CDC2 BAX PMC3995458__F1 Biosynthetic pathways of glycerophospholipids LPGAT1 PC LPCAT3 PGP LPA LPCAT2 LPCAT1 PMC5395355__F2 Phosphopeptides from the MOE and FOE phosphoproteomes are represented in some distinct signaling pathways, including Rho signaling for MOE (A), GABA signaling for FOE (B) and amyloid processing for FOE (C) HEL70 APP EZR RHO RDX CP GABARAP GPHN PMC5661483__F12 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NFKB and (BIRC6-XIAP) complexes NAIP IGF1R TRADD BIRC5 GADD45A TNF DIABLO BAG1 BIRC2 DFFA BIRC3 BIRC6 FADD CYCS BAX PMC7828503__F3 Signaling lymphocytic activation molecule family receptor (SLAMF) 3 signal transduction is mediated via self-ligation and cell–cell interactions FYN APC GRB2 TF PMC3312283__F2 This figure shows three novel intracellular signaling pathways involved in the pathogenesis of IBD VCAM1 IL1B STAT3 PMC7102672__F6 Enriched DGEs in the p53 signaling pathway The DGSs included in the CG vs HS groups, and CG vs HR groups are shown CASP3 TSC2 BAD SIAH1 PERP ATM CDK2 MDM2 CASP9 PTEN ATR PMC7102672__F5 Enriched DGEs in the PPAR signaling pathway There were three pairwise comparison groups (CG vs HS, CG vs HR and HS vs HR) in our study, and there were three kinds of DEGs from the different comparison groups UBC PLTP UCP1 AQP7 HEL-S-28 LPL APC2 PMC12191391__F4 TR2/TR4-mediated regulatory pathway in heme biosynthesis ALAS1 ALAS2 GATA1 PMC3905307__F1 Canonical (A) and noncanonical (B) Wnt signaling pathway represented by KEGG analysis TBL1X BTRC PPP3CA PPP3R2 SENP2 DKK2 MMP7 SIAH1 CCND1 SFRP1 JUN CHP2 APC CAMK2G SKP1 ARHA WIF1 FBXW11 PRKACG DVL3 NLK PLCB4 DAAM1 RAC3 NFATC2 CHD8 PPP2CA PMC8435845__F3 Research Progress on the Structure and Function of G3BP MMP2 IFNE opn PTEN GAL TNF PMC8153896__F4 Molecular Dynamics-Based Allosteric Prediction Method to Design Key Residues in Threonine Dehydrogenase for Amino-Acid Production GHB2 IVD NR1A2 THRA PMC6562660__F2 Downstream effector proteins of the major Rho GTPases, Rac1, Cdc42, and RhoA ARHA RHO RAC1 SSH1 CDC42 PMC2815188__F2 This presentation will focus on molecular mechanisms underlying transduction of BCR signals that enforce the antigen unresponsiveness of anergic B cells CXCR4 LYN DOK1 PMC8062726__F7 Summary of the regulated pathways during DCs-T ZNF730 CYBA TLR9 HEL-S-84 TRAF3 PYDC5 TP53BP1 IFNG GSDMD OASL STAT1 OAS3 SRC NOS2 IFNGR1 IRF-1 AIM2 FZD10 CXCL11 NAMPT RSAD2 IRF7 STAT2 RBCK1 IRF9 CXCL10 CARD16 TNF CYBB HLA-F ADAR PLCB2 GNA11 TXN2 IFNK CXCL9 BDKRB2 MAVS IFIT1 CD36 EIF2S1 PML IKBKE TANK IFNA1 MITA TRADD IL12A RIPK2 NOD2 TICAM1 GNAI1 MX1 RNASEL ISG15 OAS1 RIPK1 IL18 OAS2 TLR7 GBP2 GBP3 KNG1 IL10 NFATC1 IFNE BST2 IFNB1 TLR1 TRIM25 TLR3 DVL1 IL33 CD40 SYK TYK2 TXNIP IL6ST CD80 JAK1 GBP4 FADD STAT3 PMC9465172__F2 Exposure of metal toxicity in Alzheimer’s disease: An extensive review ATP7B COX17 ATP7A GSK3B APP CCS PMC8611230__F1 Melanoma susceptibility: an update on genetic and epigenetic findings ATM CDK4 ACD CDKN2A CDK6 TERF2IP BAP1 PMC8062726__F5 Protein-protein interaction underlines genes from virus response as network-hubs CTNNBL1 CMPK2 IFITM2 RNF213 RTP4 PATL1 CCL2 IFITM1 SP100 USP18 CCR1 OASL TAGAP SMCHD1 LAP3 MT1E NMI SKI PSMB9 CXCL11 IL1A IRF7 STAT2 RBCK1 IRF9 CXCL10 CARD16 CCL4 CASP10 IFI27 IL15 PARP12 CXCL9 HELZ2 ZNFX1 PLEK CASP4 PARP14 IFIT2 IFITM3 TRIM21 CD48 ZBP1 MX2 SP140L DTX3L DMXL1 SP110 LCP2 GBP1 LGALS3BP MT2A GBP2 GBP3 IL1B PSMB8 DCP1A PTGS2 BST2 SSB TRIM25 MT1M TLR3 MRPL40 MT1G MRPL17 IL15RA XRN1 PSME2 CCL3 PMC9735758__F1 IL-1RAP, a Key Therapeutic Target in Cancer SIGIRR IL36A IL33 IL36B MYD88 IL18RAP IL1B STAT3 PMC3381230__F2 Major mechanisms of immune modulation by tolerogenic DCs IL10 STAT4 CD40 CD80 TSLP PMC5621151__F1 TLR-signaling pathways TBK1 CD14 IRAK1 CXCL10 TRAF3 TRAF6 IRAK4 IRF3 CCL5 MYD88 TNF TLR3 TLR4 MAL PMC10526161__F1 Integrated Multi-Omics Profiling of Young Breast Cancer Patients Reveals a Correlation between Galactose Metabolism Pathway and Poor Disease-Free Survival PIK3CA PMC5930279__F1 Effects of choline in lipid metabolism pathway PC PEMT PMC3681204__F3 Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines PLSCR1 GCA ATG3 MAPK14 ALOX5 NCF4 EIF2AK2 RTP4 DENND5A SLPI CCR1 OASL STAT1 OAS3 SERPING1 NMI NDEL1 AIM2 CSF2RA HK2 CAPZA2 RSAD2 IRF7 STAT2 RBCK1 FPR1 CXCL10 RAB31 IL8RB CARD16 LTB4R ADAR GNA15 ISG20 GRB2 IFIH1 IRAK3 UBE2L6 SLC15A3 SIRPB1 IFIT1 IFIT3 PML IFIT2 NUMB CHUK IFITM3 TRIM21 CSF3R GBP5 TYMP PTEN LY96 CR1 ZBP1 WDFY3 CEBPB MX1 CEBPD ISG15 OAS1 GBP1 OAS2 XAF1 TAP2 GBP2 ETS2 TRIM69 TLR5 GNS NLRP12 FKBP5 SERPINB8 TNLG7A TYROBP BCL6 ALPL TNFSF10 GBP4 OSM SOCS1 PMC5793162__F1 Cancer cell signaling and regulation of alternative splicing BRAF HEL-S-30 PTBP1 APC GSK3B CD44 CASP9 BCL2L1 RAC1 SFRS3 SRSF7 MTOR PMC6094676__F1 Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma KIT BAD BRAF DKFZp781B1423 GSK3B NRAS PTEN MTOR NF1 RPS6KA1 MDM2 BCL2 CDK4 PMC2683622__F9 Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway IRAK1 TRAF3 TRAF6 IRAK4 PKD1 MYD88 PMC3979852__F8 Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages TLR4 CCR8 CCL1 PMC12202659__F7 Representative molecular pathways of breast cancer induction by PCBs compound exposure BAD CD37 PTEN RAC1 TNF MTOR MAX BCR MAFK MDM2 SYK TRAF2 RBL2 CD19 PMC2773711__F1 Canonical TCR signaling pathway ITK FYN FOS IL2 REL JUN PMC6092802__F7 DNA Damage Response (DDR) Pathway CHEK2 RAD1 RAD17 TOPBP1 HUS1 MDC1 CHEK1 BRCA1 PMC6387166__F1 Effects of distinct molecules produced by stressed cancer cells on NK cell-mediated functions TLR8 CGAS TLR7 PMC1201361__F6 Anandamide as an intracellular messenger inducing Ca2+ influx via TRPV1 FAAH AMT TRPV1 PMC5996766__F1 Of Pleiotropy and Trajectories: Does the TGFB Pathway Link Childhood Asthma and COPD? RUNX3 IRF7 SMAD2 SMAD6 TRAF6 GLIS3 SMURF1 RARA RARB NR1i1 AHR SMURF2 SOX5 SKI TGFBR3 TGFB1 FOXH1 PMC4205566__F1 A Signaling Network Induced by B2 Integrin Controls the Polarization of Lytic Granulesin Cytotoxic Cells HEL2 FLNA PEAK1 TEC ARAP1 IL1RL2 MYO1E NCK1 LCP2 SEC23B VAV3 ATM PTK2B USP9X MAPK1 LPXN PARVG c-fgr ARHGEF7 HEL-S-28 LIMS1 FCGR3A ERAP1 NEDD9 KLRB1 TRA2B GRAP2 CLTC SOS1 PXN PMC4374437__F6 Schematic diagram illustrating intracellular signaling pathways in a macrophage involved in cytokine regulation by adrenergic and cholinergic agonists and receptors following lipopolysaccharide challenge HMGB1 STAT3 PMC6608985__F15 Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFKB—IL-6 signalling axis RAC1 IL6R STAT3 PMC7555565__F3 Mechanistic network showing the highest score for a set of significantly differentially expressed genes in MG (methylglyoxal)-treated rats ATF7 ATF2 RGS2 TBC1D4 PDK4 IRS1 PDE8A TP53INP1 NDUFB4 DUSP10 CISH ZEB2 HBB NR1D1 PMC4887618__F5 The working model of STAT3 and AvrA interaction in chronic intestinal Salmonella infected in colon cancer MMP7 CCND1 IL6 STAT3 PMC7555565__F5 Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model ATF2 GRB2 DUSP8 IRS1 PMC3818842__F6 Major apoptotic pathways in SGNs induced by oubain treatment TNF FADD BAX PMC7865314__F4 Optimising radiation dose and delivery for optimal immunogenicity APC TREX1 PMC8463930__F8 Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation IL10 CD14 NGF TRAF3 SHE TRAF6 MYD88 TNF POR COX2 LTA MAX MAFK CD2 TRAF2 FADD SELE TIRAP PMC9253705__F7 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway CTSK MMP2 NFATC1 STAT3 PMC8044831__F1 Anti-inflammatory mediated effects of phytochemicals along the TLR4 signaling pathway COX2 TLR4 IRAK1 TRAF6 IRAK4 PMC6586490__F1 Mitochondrial dysfunctions in Barth syndrome PGS1 PGP PMC7500008__F2 Targets of overexpressed (a) and downregulated (b) microRNAs (N1 versus N0) among genes participating cell cycle progression and regulation (KEGG pathway hsa04110 – cell cycle) PI3 CDK2 MDM2 SMAD4 MED1 COMP DBF4 CDK7 PCNA SKP2 MYT1 PMC2733244__F2 Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity RFC2 FAR1 RFX1 CLN3 XBP1 RFC3 RFC4 PMC3061395__F10 The bifurcating parallel signal transduction pathways downstream of the IL-13R that regulate 15-LO gene expression in primary human monocytes EGR1 IL13RA1 TYK2 STAT3 PMC7580956__F4 Carbon metabolism in the plastids of E SUFU PGP FES RPIA RPE HEL-S-162eP PMC6755513__F10 Schematic chart showing the molecular pathway for Mg2+‐regulated endothelial barrier function MAGT1 TRPM6 TRPM7 PMC5103369__F6 Regulatory roles of the Arg/N-end rule pathway in autophagic flux and protein aggregate clearance SQSTM1 HTT ATE1 PMC3466494__F1 GSK3 regulates a variety of pathways involved in neurodevelopment PI3 APC PMC4515826__F7 Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity HYDIN EPHA3 ZFHX3 USH2A BRAF KEAP1 CTCF OBSCN PPP2R1A CSMD3 NEFH PTEN MTOR TTN RYR2 FBXW7 KDM5A DNAH8 ZIM2 NAV3 RIMS2 LRP1B ATM CUBN NF2 PKHD1 KIT VHL ZNF536 MUC2 FAT2 HMCN1 BCOR COL22A1 CARD11 PRDM9 CREBBP MUC4 ZNF804A RYR1 HCN1 PIK3CA PMC5008362__F1 Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach NAAA SGPP1 SMPD2 UGT8 SPHK2 SMPD4 SGMS1 UGCG CERS3 SGPL1 LASS1 SMPD1 CERS5 SPHK1 CERK SGMS2 CERS2 CERS6 SGPP2 PMC5721467__F9 Regulatory network elicited by nuclear translocation of syndecan-1 leading to inhibition of proliferation and survival DOCK8 SP1 PAX3 PMC6017063__F1 Therapeutic targets in the Notch signaling pathway DLL4 JAG2 DLL3 PMC7709037__F3 Merging network associated with the EGFR/ERBB2 signaling pathway by IPA-identified three networks (#1, #5, and #12 in ) ERBB2 EGFR MASP2 ROBO4 PARVA PMC7761891__F3 Effects of extracellular nutrients on mitochondria could activate the integrated stress response (ISR) pathway in cancer DELE1 ATF4 EIF2A OMA1 PMC3687803__F3 Canonical wnt signaling pathway APC GSK3B DKK1 PMC5048723__F4 Signaling pathways associated with differentially methylated candidate genes were predicted by Ingenuity Pathway Analysis™ FOS TPD52 CHST14 WNT10B PMC3934644__F1 Regulation and effectors of the mTOR signaling pathway BAD CDK2 EIF4E PMC5732234__F2 The immune deficiency (IMD) pathway in fruit fly and the TNF pathway in the mouse RELA REL TNF TRAF2 FADD PMC9396912__F2 Ferroptosis in esophageal cancer STAT1 GPX4 SLC7A11 IFNGR2 SLC3A2 IFNGR1 IFNG PMC10025411__F1 Neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation ATF4 TRIB3 XBP1 BAX PMC4786079__F4 Fever and the thermal regulation of immunity: the immune system feels the heat STAT1 STAT3 PMC4040260__F2 Apoptotic cell clearance: basic biology and therapeutic potential HMGB1 SIRPA CD47 ARHA PMC3404876__F2 Identification of novel metastasis suppressor signaling pathways for breast cancer HMGA2 CXCR4 BACH1 PMC7746343__F8 ATR-CHK1 and ATM-CHK2 in the cell cycle pathway ATM CDK2 CDC2 CDC25B ATR PMC3091695__F3 Stress-induced pathways in the PVN of the hypothalamus of DBA/2J (A) and C57BL/6 (B) mice EGF NFATC1 APP GNAO1 RGS2 TNF SPRY2 PMC5732234__F1 Toll pathway in fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse IRAK1 TRAF6 IRAK4 MYD88 PMC3193452__F1 Regulated necrosis in the intestine of FADDIEC-KO mice CYLD MYD88 TNF IL1B FADD PMC6818007__F3 VEGF (vascular endothelial growth factor)‐angiogenesis signaling and cell cycle regulation pathways PLCG1 EGFR NRG2 VEGFA MYC MTOR RICTOR KDR ATM CDK2 SRC CDC2 ITGAV ATR PMC4980330__F2 Regulation of the Hippo pathway by multiple upstream signals AMOTL1 LATS1 RHO LPA LATS2 HMGCR PMC4980330__F1 The core of the Hippo signaling pathway LATS1 PMC6818007__F1 Telomere biology and damage signaling ATM CDK2 CDC2 TPP1 ATR PMC7833179__F1 Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection? IL16 IL33 BCL2 MIP TNF XBP1 SIRT1 SIRT3 PMC7396774__F5 Re-analysis of 14 selected genes using KEGG pathway enrichment E2F4 SMAD2 APC SMAD4 DBF4 CDK7 CDK6 CDC45 ORC2 CDC20 CDC6 SMC3 CDK2 MDM2 CDK4 CDC2 PCNA SKP2 MYT1 PMC5647956__F1 Artemisinin biosynthetic pathway in A MVD MVK IPP MVP PMC5721467__F4 Upstream regulators and downstream biological effects predicted by Ingenuity Pathway Analysis on the proteome level IL13RA2 CSF3 TRAF1 LYN NOX4 PRKG1 RGS2 TGFB1 PMC9032679__F2 Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer MFN1 MFN2 OPA1 BAX PMC3817541__F1 Mechanism of activity-dependent transcriptional repression by MeCP2 NPAS4 BDNF PMC9580888__F4 Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis SORL1 MTOR SPNS2 PMC2651818__F3 Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network HEL-S-49 GPN3 GPN2 FBP1 GPD2 GPD1 HEL-S-68p PMC9570456__F2 Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment? ADA NT5E ADK PMC7190945__F2 VSL#3 on intestinal barrier function STAT1 LPL PMC7246584__F1 Interplay between HCV-induced oncogenic signaling pathways EGF SOCS3 CLDN1 EGFR CD81 STAT3 PMC7352559__F2A Klotho and the Treatment of Human Malignancies USP4 USP15 SMAD2 APC SMURF2 GSK3B SMAD4 MTOR IRS1 PMC5394902__F2 Canonical pathway and upstream regulator effects analysis identifies inflammatory response, migration, and proliferation pathways enriched in trkB.T1 KO astrocytes HEL-S-62p ITGAM CFB PTGS2 TNF PPARG PMC8373118__F4 Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative IRF7 TRAF3 IRF3 MYD88 MAVS PMC5877662__F3 cGMP signaling pathway NPS GC PGC PMC3687803__F1 Different layers of the epidermis, and the functions within those layers regulated by VDR and its coactivators CD14 NR1i1 UGCG ELOVL4 FLG SRC PMC7409063__F1 Extracellular vesicle (EV) biogenesis and signaling between neighboring cells RAB35 RAB27A ARHA PMC8740576__F5 HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR TGS1 NCBP3 EIF4E MTOR PMC9060113__F2 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes TNF IL1B IFNG PMC11670804__F5 Visualization of GO terms and DETs connected to the development of HFs in sheep SFN LDB1 SMAD4 KRT23 SOX9 ZDHHC21 NLRP3 KRT33A ALOX15B KRT27 SMARCA4 NGFR MAML2 DSG4 RPE GGCT NCOR2 HOXC13 ROCK2 TGM3 ANXA1 ADAM9 NFATC1 FOS DBI PLCB2 EP300 FADS2 LRP4 AFMID TXNIP PRKCH ACADM PMC9316611__F2 Indoor Secondary Pollutants Cannot Be Ignored: Third-Hand Smoke EGF FOS EGFR MYC BCL2 RPS3 JUN PMC8643499__F7 Loss of Zic3 impairs planar cell polarity leading to abnormal left–right signaling, heart defects and neural tube defects MAPK8 ARHA CELSR1 RAC1 CELSR3 DVL3 CELSR2 DVL1 DAAM1 DVL2 VANGL1 JUN ZIC3 PRICKLE2 PMC2869400__F9 A model of Gfi-1-mediated repression of CDKN1A and other Miz-1 target genes CDKN1A MYC GFI1 PMC9323599__F3 Edwardsiella ictaluri T3SS Effector EseN Modulates Expression of Host Genes Involved in the Immune Response CD14 STAC TLR9 IRF7 LBP TRAF6 CD40 DES IRF3 RAC1 TLR3 TIRAP PMC10149954__F2 Receptors that bind to PEDF and their therapeutic roles in retinal diseases MMP7 MMP2 APC MMP9 GSK3B LRP5 LRP6 TNF BMP4 PMC9060113__F1 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes BAD PHLPP2 GSK3B PTEN PHLPP1 PMC9652959__F2 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways NLK APC GSK3B LRP5 SMAD6 SMAD4 LRP6 RHO SMAD1 PMC11357207__F4 Working model to propose ABC-transporter mediated cholesterol efflux reduces the pro-inflammatory immune response that initially occurs from T TLR4 ABCG1 ABCA1 PMC9652959__F4 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways SUFU FOS TRAF6 BMI1 RHO JUN PMC6406942__F2 Base Excision Repair (BER) in mitochondria NEIL2 IL1A SMUG1 NEIL3 POLG OGG1 PNKP NEIL1 PMC7432774__F1 Biology of tumor hypoxia ATF4 MTOR XBP1 PMC3025384__F2 JAK/STAT3 signaling pathway transmits information from cytokine/chemical signals outside the cell, through the cell membrane, and into the gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell NLK TLR4 TRAF6 MYD88 MTOR STAT3 PMC8174842__F5 Dickkopf-1: A Promising Target for Cancer Immunotherapy IL13 CKAP4 DKK1 PMC3025384__F3 Wnt signaling plays central role in embryogenesis and human diseases including cancers BAD TBP TRADD ATF2 EGFR TRAF6 BCL2 TRAF2 JUN BAX PMC3724399__F1 PI3K/Akt/mTOR pathway TSC2 TSC1 PTEN EIF4E RHEB PMC8508518__F2 Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer SOCS3 SRC SOCS1 PMC8147235__F2 Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation NLRP3 MTOR IL23R PMC5959746__F3 The biology and therapeutic management of melanoma brain metastases PTEN CCL2 TNF PMC7492550__F1 Identified mechanisms of molecular resistance to anti-TNF therapy in IBD patients CD14 IL7R IL23R OSM PMC8483971__F1 Ethnic Differences in Iron Status BMP6 HAMP BMP2 HFE TFR2 PMC7780046__F3 Nuclear factor kappa B (NF‐KB) signaling by N‐myc downstream‐regulated gene 2 (NDRG2)/protein phosphatase 2A (PP2A) complex NDRG2 RELA RELB CD40 PTEN LTBR PMC7780046__F5 Enhancement of epithelial‐to‐mesenchymal transition (EMT) via the loss of N‐myc downstream‐regulated gene 2 (NDRG2) activity NDRG2 SMAD2 SMAD4 CDH2 PMC10780299__F4 Activation of the NFKB/MAPK signaling pathway by saponins regulates the expression of a series of immune-related cytokines, NO, surface-stimulating factors, and mRNAs and/or proteins of the cell cycle ATF2 IL2 MYD88 CSA2 PMC10780299__F3 Saponins activate the TLRs signaling pathway through TLRs, upregulate class I and II MHC molecules in APCs, and promote antigen capture, processing, and presentation APC CD80 PMC8414384__F2 Hypoxia in inhibiting dendritic cells by VEGF signaling in tumor microenvironments: mechanism and application VEGFC NRP1 VEGFA ARHA MYD88 VEGFB PMC6433121__F4 Proteins that Are Rhythmic in the Pentose-Phosphate Pathway Peak in Anti-phase to Those in Glycolysis HEL-S-49 ENO3 FBP1 EMP3 GPD1 PMC7936245__F4 Possible proximal tubule epithelial cell signals in glomerulonephritis and renal cell carcinoma NLRP3 FGF23 EPO CYP24A1 PTH CCL2 SIRT1 CYP27B1 STAT3 SPDL1 PMC5594548__F7 RNAi amplification, spreading and transcriptional gene silencing pathways ZFP1 SMG6 SMG5 PMC6812026__F2 Important metabolism-related cellular signaling cascades where FKBP51 was shown to play a decisive role (see main text for further details) CORT UCP1 IRS1 PMC11657595__F2 Mechanisms of GDF15 expression, maturation and secretion KEAP1 GDF15 ATF4 ATF3 PMC7344784__F5 Activation of ATM signaling predicted by IPA-based pathway analysis ATM CDK2 ATF2 MDC1 MDM2 ATR H2AX PMC8072021__F3 Cellular Prion Protein—ROCK Connection: Contribution to Neuronal Homeostasis and Neurodegenerative Diseases APP ARHA ELL PMC8883485__F2 FoxO transcription factors regulate mitochondrial biogenesis UROD NRF1 FXN CYB5R3 PDK4 HMOX1 TFAM SIRT1 PMC5743386__F9 Proposed model shows that MTH-3 induces G2/M phase arrest, autophagy and apoptotic cell death (death receptor/mitochondrial pathways and ER stress) in human breast adenocarcinoma MDA-MB-231 cells MT3 ATG12 CCNB1 CDC2 DKFZp686F0183 FADD PMC9465411__F5 Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents VCAM1 PAK4 PMC5787447__F5 Current research on head and neck cancer-associated long noncoding RNAs VEGFA PTEN EZH2 FZD5 PMC5787447__F3 Current research on head and neck cancer-associated long noncoding RNAs CDKN1A TSHR IQGAP1 BMI1 EZH2 PMC5787447__F2 Current research on head and neck cancer-associated long noncoding RNAs CDK4 PTEN EZH2 CDK6 PMC7854724__F6 TGFB signalling acts as a molecular brake of myoblast fusion SMAD2 TGFBR1 TGFBR2 SMAD4 PMC9305853__F4 Global analysis of differential gene expression within the porcine conceptus transcriptome as it transitions through spherical, ovoid, and tubular morphologies during the initiation of elongation PLN IGF1R IGF1 FGF10 CXCL12 TGFB1 IL1B FGFR2 FGF7 IFNG PMC5372786__F1 Pathway for synthesis of ceramide, sphingomyelin, and sphingosine-1 phosphate S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 PMC6025071__F1 IDH pathway and targets in acute leukemia HEL-S-26 BCL2 BAX PMC6537282__F1 New biologics and small molecules in inflammatory bowel disease: an update EPO AK3 TPO PMC5381705__F4 Target genes of Tongcheng/Landrace specific DEmiRNAs' KEGG pathways enrichment analysis (a) Landrace specific DEmiRNAs target genes enriched in cell cycle pathway BAD NGF TRADD CASP10 DBF4 CDK7 CASP3 SMC3 CDK2 CASP9 CDK4 RAD21 FADD PCNA MYT1 PMC8267408__F1 Chemistry-Assisted Proteomic Profiling of O-GlcNAcylation NAGK PGM3 OGA OGT GALK2 PMC7438479__F8 Pathway that Tisp40 regulates Ischemia-reperfusion induced pyroptosis in kidney NLRP3 IL1B GSDMD PMC10779351__F5 Illustration of Ferroptosis in Pancreatic Beta Cells and Its Relation to NADPH GPX4 HEL-S-64p TNF TF GLS PMC10779351__F4 Illustration of Insulin Signaling and Resistance Pathways MTOR TRAF2 IRS1 PMC10779351__F3 NADPH in Insulin Secretion from Pancreatic Beta-Cells MNT SENP1 PMC7247689__F2 Mitochondrial homeostasis is based on the balanced interplay between biogenesis and mitophagy PINK1 NRF1 MTOR TFAM PMC10779351__F2 NADPH Production Pathways in Cells ME1 HEL-S-26 MNT MTHFD1 ME3 MTHFD2 HEL-S-162eP PMC9035791__F1 Th17 Pathway in Vascular Inflammation: Culprit or Consort? RORC IL18 TNF IL17RC IFNG FOXP3 PMC4066870__F4 Smoke mediates EGFR/Src-dependent and independent cell migration LIMK1 EGFR SRC PMC9130572__F2 Pyroptosis: Role and Mechanisms in Cardiovascular Disease NLRP3 HMGB1 GSDMD PMC8059808__F2 Boolean module is a dynamic module including Snf1, PKA, and TOR pathway as well as crosstalk between them DAP KIN SELL PMC4959097__F1 Cholesterol biosynthetic pathway PMVK MVD IDI2 MVK IDI1 HMGCR PMC9035791__F4 Th17 Pathway in Vascular Inflammation: Culprit or Consort? RORC IL18 FOXP3 PMC5045062__F2 Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism HEL-S-26 ACO2 GYS1 ACLY HEL-S-87p TG PGAM1 HEL-S-133P PHGDH HEL60 HK2 PMC7780046__F1 N‐myc downstream‐regulated gene 2 (NDRG2) is a key regulator of cellular stress responses NDRG2 PTEN PMC6627250__F1 Neoplastic transformation of melanocyte SPARC BRAF NRAS PTEN NOTO CDKN2A MME FBXW7 TERT STAT3 POLI PMC7845582__F2 Vaccine Therapies for Cancer: Then and Now TAP2 CD40 PMC7677583__F1 JAK inhibition and immune regulation by the JAK pathway IL21R EPOR PRLR GHR IL7R TYK2 JAK3 JAK1 IL23R PMC3964483__F1 Outside the Box Signaling: Secreted Factors Modulate GnRH Receptor-Mediated Gonadotropin Regulation GNRHR EGR1 FOS SF1 SRC FSHB CGA LHB JUN TF PMC11944057__F2 Crosstalk between the PI3K/AKT/mTOR pathway and the MAPK pathway PTEN MTOR IRS1 PMC4216797__F3 Mechanism and Role of AMPK activation TSC2 ULK1 TSC1 FOXO3A RHEB CAMKK2 PMC10981134__F1 Main alterations in TCR signaling pathway and accessory molecules associated with autoimmunity/immunodeficiency ITK LCK GRB2 CD80 STAT5B LAT FOXP3 PMC9500666__F8 Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells ATF4 BCL2 BAX PMC4528105__F1 A Protein in the Hippo Signaling Pathway Serves as a Point of Cross-talk to the mTOR Signaling Pathway♦ RICTOR AMOTL2 LATS1 MTOR LATS2 PMC8040477__F4 Epidermal growth factor receptor (EGFR) signaling pathway and potential mechanism of resistance to cetuximab and panitumumab EGF HGF MMP9 EGFR HBEGF MTOR EPHA2 AXL TGFA PMC8949405__F2 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer MAPKAPK2 BAD PPP3CA MAPK3 CASP9 SRC PXN CDC42 PMC8949405__F1 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer PRKCE BRAF EIF4E HIF1A MTOR IRS1 DDIT4 STRADA RHEB TSC2 RICTOR IGFBP2 STK11 PIK3CA RPS6 EIF4B PMC5362437__F5 Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3Beta-involved Wnt/Beta-catenin pathway LEF1 SOX2 GSK3B PMC8652015__F4 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy NTSR1 EGR1 IGF1R PMC6606008__F4 Hippo Pathway for tumor suppression VGLL4 LATS1 LATS2 PMC6606008__F3 Wnt signaling pathway with and without ligand binding and APC mutations APC PMC6606008__F2 Process of Hedgehog pathway begins on binding of specific ligands such as exo-secretion ligand Shh bind to the trans-membrane receptor PATCHED1 (PTCH1) it initiates the HH-GLI pathway DKFZp686L0365 SUFU PTCH1 GSK3B SMO PMC4283829__F9 Key role of transient receptor potential melastatin-2 channels in amyloid-Beta-induced neurovascular dysfunction TRPM2 PARG CD36 PMC8237272__F6 LGR5 enhances the osteoblastic differentiation of MC3T3-E1 cells through the Wnt/Beta-catenin pathway RUNX2 APC GPR49 PMC3417440__F1 Cell death regulation: Signalling pathways and potential sites for pharmacological intervention INA BAD TRADD RHO TNF MTOR APAF1 SRC CCND1 BCL2 CDK4 TRAF2 FADD STAT3 BAX PMC10095594__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 BCL9 PMC3889573__F2 Ras, cAMP/PKA, and MSIL signaling pathways in C MSI1 MSL1 GPR4 NRG1 RAC1 CDC42 PMC3889573__F1 HOG signaling pathway in C AQP1 ATF1 GPD1 PMC3889573__F3 Ca2+/calcineurin, Rim101, and Pkc1/Mpk1 MAPK signaling pathways in C HEL-S-11 SP1 PMC11530815__F3 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment FADD BAX PMC11530815__F2 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment BAD GRB2 MTOR PMC8601278__F3 Bioinformatics analyses of the pathogenesis and new biomarkers of chronic obstructive pulmonary disease NDRG2 RPS4X TIMM44 ARHH RIOK1 P2RY8 CD6 MYC SNRPN TAF9 ORM1 THOC7 GPX7 ITK KLHL32 CD8B MRPL1 RPP38 TBP TIMM9 TCF20 CNOT10 CCR7 SATB1 IL7R KLRG1 BPI HEL-S-281 RUVBL1 SLC25A37 LTB FXN PIGY TOMM20 GPR18 ATP10A BCL2 CYFIP2 RORA IL27RA NUP88 LAT MPO ATL1-beta GMDS DEFA4 CD48 UBASH3A PLD4 FBXL12 PINX1 DPH5 RPS27A BIN1 COPS8 KLRK1 CD40LG PIGP CD3G LY9 GATA3 CD3D CD5 CD96 FLT3LG GTF2F1 HPR LEF1 RNF157 HP KLRB1 LCK CD7 CD22 ZAP70 MLLT3 PEX26 PLEKHB1 CYCS RPS23 PMC10535809__F2 Host and HBV Interactions and Their Potential Impact on Clinical Outcomes SET PMC7176436__F1 De novo and salvage pathways of purine synthesis in eukaryotic cells ADSL GMPR APRT PMC8233740__F1 Using Diatom and Apicomplexan Models to Study the Heme Pathway of Chromera velia FECH UROD UROS CPOX COCH PMC2745384__F6 RCAN1 mediated regulation of cell proliferation and apoptosis: Schematic shows that GC-dependent GR activation and subsequent MAP kinase-dependent phosphorylation enables GR binding to GRE sequences on target genes GC RCAN3 RCAN1 PMC8000936__F4 DDX11-mediated regulation of EZH2-p21 and PI3K/AKT/mTOR signaling pathways in HCC cells DDX11 EZH2 MTOR PMC3921546__F1 Representation of epidermal growth factor receptor pathway in response to therapy with anti-epidermal growth factor receptor inhibitors in wild-type and mutant patients BRAF EGFR PTEN MTOR PMC8289577__F1 Hair Cell Protection from Ototoxic Drugs BAX PMC5599913__F1 The SMC1 participating in DNA damage repair signaling pathway ATM MDC1 RAD50 MRE11A RAD18 BRCA1 PMC8876688__F1 Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus GCLM ATG2B HEL-S-30 GCLC ACLY DKFZp686F0183 MTHFD2 IL1B TXN SRXN1 FASN PMC12220111__F1 Modular engineering design for the compartmentalized synthesis of taxifolin in the peroxisomes of S PPY CIT FAT1 PMC2593565__F3 Epithelial barrier function by lactobacilli LTA EGFR MYD88 PMC3442422__F1 The Sre1 regulatory pathway ERG UBR1 OFD1 PMC7037748__F2 Regulation of the Wnt/Beta-catenin signaling pathway when it is inactive (OFF) and when it is active (ON) ZNRF3 RNF43 SOST LRP5 LRP6 APCDD1 DKK1 GPR49 PMC8131840__F2 Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies STAT1 JAK3 JAK1 STAT3 PMC7037748__F1 Wnt/Beta-catenin signaling pathway, which is inactive in the absence of Wnt ligands (OFF) and active upon binding of Wnt ligands (ON) GSKIP APC LRP5 LRP6 BCL9 PMC6448643__F1 Illustration showing the activation of a T lymphocyte (via a three‐signal pathway) by an antigen‐presenting cell CD40 JAK3 MTOR PMC6700246__F1 Sphingolipid metabolic pathway PC CERS3 LASS1 DES CERS5 CERS2 CERS6 HEL-S-5 PMC3542528__F4 Protein network analysis of hits reveals multiple connections between signaling molecules and Golgi proteins DGKD MARK4 GCK TEC OSBP FGFR2 hCG_1641087 CDKL2 SRPK1 EPHA1 AK7 AXL FBP2 GOLGB1 NPR2 NRBP1 ERBB3 CXCL10 PRKX AURKB GABARAPL2 COPB2 PTPRU DGKZ PPP2CA DUSP2 VRK3 PRKCE TGFBR1 NRBP2 RIPK2 LCP2 GBP1 BMX CAV2 NEK11 CSNK1G2 STX7 TBCA SNAP25 GAP43 PTPRF NLK CCK RPS6KB1 GJA1 MAP3K2 NEK2 KIF20A SRPK2 FLT3 PMC9053805__F5 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps CD14 HLA-DPA1 CD37 MS4A1 SET HLA-DQB1 SLAMF7 CSF2RB TNF CD69 PTPRC IL10RA GPNMB STAT3 PMC9053805__F4 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps FHL1 F13A1 SCG2 NDN SST SET PTN MSX1 TNF SLIT2 VIP GPR18 CITED2 IGF1 CD27 BMP5 CCL19 GREM2 CXCL12 TNFRSF17 STAT3 PMC4576153__F1 Negative regulators take action at almost all steps of TLR signaling IRF7 CYLD IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 FADD MAL PMC3542528__F5 Various subnetworks of signaling molecules that regulate Golgi structure ASAP1 MYO1C ROCK1 TGFBR1 HEL-S-15 KIF1A COPA PTEN OSBP FGFR2 TAOK2 CLINT1 MYO6 LIMK2 MAPRE1 PDGFRA ASAP2 GORASP1 NLK CASP3 MAP4K2 PAK1 PPP3R1 STK4 EVI1 DGKZ PIK3CA RAF1 DUSP2 PIP5K1A TRAF2 DUSP8 CLASP1 PMC8905735__F9 Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis SMAD2 TGFBR1 PMC4597147__F4 Regulated protein networks in GM-BMMs versus M-BMMs KEAP1 BIRC5 MYC IDI1 HIF1A FBXW7 DOK1 DLG4 NQO1 USO1 FYN LPL GHR SREBF2 ITSN1 RPIA NOS2 TFAM APOE NR1H2 AACS ENO1 NCOA6 TNF PLCB2 RBBP7 PCNA CD36 ANXA4 RHO HEL-S-128m TOP2A ATP6V0D2 RRM1 FABP5 CSN2 PFKP CD19 FASN STX7 MS4A1 EHD1 VAMP4 RAC1 IFNB1 POLD3 CBL FOXA2 NLK RFC1 HNF4A SLC2A4 LYN DOCK2 PYGL GPX4 RBBP4 PRIM1 CD74 ZFP36 FDPS CYP2A13 ELMO1 HEL-S-281 GM2A GSTM5 FOS CSK Nbla10317 IL8RB HMGCS1 FOXO1 MVD GRB2 HBB NR2C2 MED13 CIDEA LAT CDC42 PML PAG1 UBC ELAVL1 ATM LPIN1 ATF4 CIDEC SLC7A2 PTPN11 NR1H3 AEBP1 NFE2L2 CXCL2 HEL-S-102 CD22 PITPNC1 ZAP70 MAPK8IP1 STAT3 PMC7081333__F8 Piscidin-1 anticancer signaling pathway MFN1 MFN2 FIS1 OPA1 PMC6260860__F3 Different gene expression profiles in metabolic pathways of E PTS CS PC ATR HEL107 RPE HEL-S-162eP PMC4819695__F1 MYC: regulator of post‐transcriptional mechanisms FBL NCL MAX MYC BUD31 POLL POLI PMC7250912__F1 Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways BRAF PMC7038207__F2 Connexin hemichannels in mechanotransduction of osteocytes SOST RHO PMC3828201__F1 ERK and PI3K signaling networks are shown, with illustrations of feedback loops and cross talk FOXO3A EIF4E IRS1 PMC8652015__F2 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy TH COX2 CCR2 MYC USP28 ADRB2 PTEN CCL2 MTOR HEL-S-133P PRL STAT3 PMC4816099__F2 Controlling a variety of extracellular and intracellular processes via the phospholipid code TRADD ARHA PMC1866250__F7 Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance DGAT1 TG PMC7892797__F1 All detected PLA2/COX pathway genes and regulatory factors and alterations in their transcription levels between patients with schizophrenia and healthy controls PTGER2 PTGIR PTGIS COX1 FACL4 PTGER1 PTGER4 CREB1 PTGDR2 HCAR2 PTGDR PMC6390002__F2 Comparative analysis of genes in regeneration-related signaling pathways of regenerative animals TCF3 SOX2 NODAL DUSP9 SMAD2 LIF FGF2 TBX3 APC GSK3B LATS1 LATS2 BMP4 GRB2 SMO STAT3 PMC6032276__F6 Differential regulation of skin barrier proteins by Rhodiola crenulata root extract AHR FLG CYP1A1 IVL OVOL1 PMC4665079__F6 Autophagic signaling pathway ULK1 ATG12 ATG3 LAMP2 BCL2 STX17 ATG10 VAMP8 SNAP29 DKFZp686F0183 PMC4132373__F1 A healthy neuromuscular junction (NMJ) is a tripartite synapse composed of a motor neuron (MN) terminal synapsing onto a muscle fiber SEMA3A NRP1 CD44 APP EPHA4 PMC4665079__F4 Death receptor signaling pathway TRADD TNF TRAF2 FADD PMC9488186__F1 Promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis TSC2 ULK1 DEPTOR SGK1 RHEB PMC9274113__F2 Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases CLC MOK ASL PMC4665079__F2 Mitochondrial apoptotic pathway APAF1 HTRA2 PMC6829479__F1 Effect of pharmacological and transcriptional inhibition of lysine-specific demethylase 1 (LSD1) on induction of the cell cycle and DNA damage response (DDR) pathway in microvascular endothelial cells (HMEC-1) CCNB2 ATRIP PCNA CCNE1 PMC8278111__F1 Complex role of Wnt ligands in type 2 diabetes mellitus and related complications NLK COX2 APC GSK3B LRP5 CCND1 SRC LRP6 ARHA RYK BCL9 CDC42 PMC9169354__F2 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer AMOT AREG MYC LATS1 ID1 FRMD6 PMC9169354__F1 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer NF2 VGLL4 LATS1 LATS2 PMC8151045__F1 PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma CD80 PMC1929113__F6 Upregulation of cyclins and CDKs in melanoma cells ATM CDK2 CD2 CCNB2 SMAD4 ATR SKP2 PMC3179938__F3 Top IPA generated network KLRB1 IRGM SOCS4 ADFP ALOX15 ALOX12 CD40 LILRA2 PIBF1 PMC6444272__F2 Herb-compound-target-signaling pathway network of BSJPD TH VEGFA PTEN BAX PMC5959770__F2 Perspectives on Glycosylation and its Congenital Disorders GANAB DOLK COA7 DDOST PMC8437140__F2 H19 in liver injury and fibrosis EPCAM PTBP1 BCL2 CCL2 PMC6873994__F4 Predicted potential targets to combine with MAPK/ERK inhibition, using graph analytics PRC1 TUBB POLR2G PPP2R1A RHO POR LAT MLST8 PMC8437140__F1 The bile acid/FXR pathway by lncRNAs CYP8B1 APOC2 TG CYP7A1 PMC7691682__F8 Some transcripts encoding enzymes involved in the glycosylphosphatidylinositol (GPI)-anchor protein biosynthetic pathway are down-regulated in the CF specific medium (CFSM) culture condition (G condition) PIGF PGAP1 GPAA1 PIGC PIGW PIGH PIGM PISD PIGK DPM2 PIGL PMC8196898__F5 Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer MAML1 COX2 DLL4 MMP9 NOTCH1 BCL2 COMP STH IRF6 PMC6993871__F6 Simplified schematic of the cholesterol biosynthesis pathway and MARCH6 targets DHCR7 EBP DHCR24 HMGCR PMC8014339__F7 F528 treatment ameliorated smoke-induced inflammation and emphysema through NFKB signaling pathway MMP2 MMP9 IL6 PMC10816189__F5 Cell cycle metabolic pathway, with Zhuansihao serving as the control and 071113 as the experimental group CD14 ORC6 SMAD2 APC SMAD4 STAG1 ORC3 CDK7 CDC45 STAG2 ORC2 CDC20 CDC6 SMC3 CDK2 CD7 MDM2 PCNA SKP2 PMC10816189__F6 Plant hormone signal transduction pathway, with Zhuansihao serving as the control and 071113 as the experimental group BIN2 EBF2 COIL PMC5850959__F6 Transcriptomic data shows immunometabolic effects of vitamin D SDHC CS DLD IDH3B MDH2 FH ACO2 SUCLG1 OGDH SUCLG2 SDHD SDHA SDHB PMC3350847__F2 Canonical Wnt pathway APC GSK3B PMC5563989__F2 The apoptosis regulatory network under ER stress ATF4 EIF2A PMC11586091__F1 JAK/STAT3 signaling pathway regulated by circRNAs NLK CCL2 STAT3 PMC6398012__F6 Proposed mechanism by which type 2 diabetes (T2DM) and aerobic exercise can affect the brain and lead to alterations of hippocampal glucose metabolism with subsequent effects on synaptic plasticity-associated proteins NLRP3 IL16 MTOR SIRT1 PMC6027299__F2 Global view and function analysis of the ceRNA network in GC CXCL1 KIF23 TTK TFRC RIPK2 TOP2A MTHFD2 DTL RRM2 ARHGAP11A PROSER1 NUP107 PRKDC RBL1 OPA1 CHTF18 LRP6 CENPK CLSPN ATP13A3 SMC2 TYMS HJURP CENPN TONSL CENPU PCNA SKP2 PMC11586091__F3 Function of exosomal circRNAs in tumorigenesis BPTF KDR E2F2 ANXA2 PDK2 ARHGAP24 PFKFB2 RSF1 MTOR TMED10 MTA2 PMC4968756__F7 Model for p53-mediated resolution of replication barriers HLTF MRE11A RAD18 ZRANB3 POLI PMC6492315__F4 Schematic overview for the roles of miR-24, miR-23a and miR-145 in TGFB signaling in AKI CASP3 PLG FOXO3A APAF1 SMAD2 TGFBR1 TGFBR2 SMAD4 SP1 CASP8 PMC8315560__F1 Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer GPT PMC8181757__F6 CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline ATF4 EIF2A INS PMC3328674__F1 Exercise-stimulated glucose uptake in skeletal muscle NRF1 RAC1 MTOR PPARG NDUFB6 PMC3098671__F2 Endoplasmic-Reticulum Calcium Depletion and Disease ATF4 CHP1 EIF2A XBP1 PMC5545609__F1 Normal endothelial cell metabolismA schematic of the principal pathways in healthy EC metabolism and the rate-limiting enzymes, carriers, and transporters (shown in blue) F2 HEL107 HEL-S-104 GLS PMC8085551__F6 Transcriptomic and Metabolomic Profiling Reveals the Protective Effect of Acanthopanax senticosus (Rupr. & Maxim.) Harms Combined With Gastrodia elata Blume on Cerebral Ischemia-Reperfusion Injury ASAH2 MTAP HPD NME6 PAH DEGS2 TK1 PMC4654537__F6 Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule HEL-S-302 SCAI FCHO1 CMBL NR1C2 PALM CHRNB1 CLPP PMC5545609__F4 Diabetic endothelial cell metabolismIn diabetic ECs, hyperglycemia increases production of ROS through a variety of intracellular sources, including NADPH oxidase, xanthine oxidase, uncoupled eNOS, and impaired pentose phosphate pathway (PPP) F2 F3 PARP1 HEL-S-162eP PMC5005329__F1 Current view on T cell NNCS in regulation of immune function ChAT APC ZAP70 ORAI1 STIM1 PMC5053480__F5 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation SERPINC1 PVALB POSTN COL12A1 MYL1 COMP COL1A1 PMC8268101__F2 Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors RAC1 CDC42 STAT3 PMC5053480__F4 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation CALU PVALB POSTN MYL1 TBCA RBM8 NME2 SFRS3 COL1A1 MDH2 MTAP HEL-S-78p NAA38 COL12A1 TRA2B CRABP1 APRT CETN3 COMP ZRANB2 PMC6787681__F4 AT-rich interactive domain 1A (ARID1A) chromatin remodeling abnormalities in ovarian clear cell carcinoma (OCCC) CDKN1A MYC EZH2 MTOR ARID1A PMC9144171__F3 Endocardial Regulation of Cardiac Development TBX20 NPPA TBX2 BMP2 POSTN TBX3 VCAN VEGFA MSX1 NRG1 HAS2 ERBB4 HEY2 BMP10 TWIST1 ERBB2 NOTCH1 MSX2 HAND2 PMC6192708__F2 Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine IGF1 SFTPA1 IGFBP4 APP PMC8517477__F2 STING Signaling and Sterile Inflammation HMGB1 CGAS CXCL10 PMC8517477__F1 STING Signaling and Sterile Inflammation TBK1 CGAS IRF3 PMC8393318__F8A Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative TSC2 CHUK BAD RPS6KB2 CREB1 PTEN MTOR PMC10522995__F1 CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1 CRTC2 PMC10376827__F1 Dissecting the Protective Effect of CD8+ T Cells in Response to SARS-CoV-2 mRNA Vaccination and the Potential Link with Lymph Node CD8+ T Cells APC TNF IFNG PMC7283386__F2 Signaling pathways in wear debris-activated osteoblasts BCL2 BAX PMC7855700__F1 Main IDO1 and ARG1-mediated pathways that regulate autoimmunity, cytotoxicity, and neuroprotection IDO1 AHR SRC ARG1 PMC4905428__F1 Regulation of Smad4 by the FGF/MAPK and Wnt signaling pathways EGF SMAD2 APC SMAD4 PMC10935121__F8 DEG pathways involved in the sesquiterpene synthesis pathway MVD MVK IPP PMC8071330__F3 Ovarian cancer stem cell (OCSC)-associated signaling pathways PTCH1 LRP5 LRP6 SMO PTEN NOTCH3 STAT3 PMC6896163__F2 FOXO1 regulates activation and function of dendritic cells RICTOR TLR4 CCR7 MTOR FOXO1 PMC4237178__F4 Canonical and non-canonical Wnt pathways exert opposite effects on the formation of the vertebrate NMJ MUSK LRP4 RHO DVL1 PMC11781520__F1 MiR-29s in the signalling of innate immunity TLR5 STAT2 IRF9 IL6 CCL2 MYD88 TNF NOD2 STAT1 TLR8 COX2 TLR7 TYK2 CD80 JAK1 SOCS1 PMC6382076__F1 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells IFIT3 TBK1 IFIT2 TANK HLA-G TRADD IFITM3 IRAK1 IRAK2 IFITM2 MYC TGFBR2 TRAF3 SMAD4 TRAF6 IRAK4 CCL2 MYD88 HEL-S-104 NOD2 MX2 OASL STAT1 TLR4 MT2A GBP2 CSF2 MAL STAT2 IRF8 IRF9 MMP9 ATF3 IRF3 TRIP6 IFNAR2 TNF IFNAR1 HLA-A RELA TYK2 JAK1 MAPKAPK3 FADD TGFBI PMC8583789__F7 RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair RIF1 SHLD2 SHLD1 BARD1 ASTE1 MRE11A BRCA1 PMC2945950__F5 Moral graph Dm obtained from BCR pathway GSK3B PLCG2 CD81 BTK CD72 BCL10 RASGRP3 BASH CD22 LYN GRB2 SYK CD19 PMC4275311__F3 Cellular and metabolic functions for autophagy in cancer cells KEAP1 TRAF6 MTOR PMC10750294__F8 MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion NPM1 MMP2 MMP9 PCNA PMC2945950__F6 Triangulated graph Dt obtained from BCR pathway GSK3B PLCG2 CD81 BTK CD72 BCL10 RASGRP3 BASH CD22 LYN GRB2 SYK CD19 PMC4275311__F1 Cellular and metabolic functions for autophagy in cancer cells ULK1 BRAF ATF4 EIF2A MYC DKFZp686F0183 PMC2945950__F1 BCR signaling pathway BTK BCL10 BCR DAO BASH CD22 LYN GRB2 SYK BOLL CD19 PMC8092109__F9 Cinnamaldehyde inhibits the growth of Phytophthora capsici through disturbing metabolic homoeostasis MCC IVD CAD PMC2945950__F2 ERBB signaling pathway EGF BTC SHE MTOR NRG4 JUN PMC8525858__F7 Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2 TLR5 KEAP1 NQO1 PMC6468910__F3 ER stress and chemo-resistance: Role of protein kinase R-like endoplasmic reticulum kinase (PERK) KEAP1 ATF4 EIF2A HIF1A BAX PMC9033823__F6 Oncogenic circuit involving FUS-DDIT3, the IGF-IR/PI3K/AKT pathway, and the Hippo/YAP1 axis in MLS YAP1 IGF2 LATS1 PMC12164393__F2 ICI myocarditis TH ANGPTL2 CXCL10 CCL5 CCL4 CXCL11 CCL3 PMC6481335__F4 Heatmap and expression values of probe sets related to irinotecan metabolism in both liver and tumor CES2 CES1 APC ABCC1 ABCG2 ABCC2 CES3 UGT1A1 PMC5713423__F1 Schematic representation of Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) signaling mediated T cell priming in tumor microenvironment CGAS CD80 PMC3060045__F2 ErbB receptor signaling and regulation EGF ERBB4 ERBB2 EGFR GRB2 SHE SRC TGFA WWOX PMC9561988__F1 Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer WEE1 ATM CDK2 BRCA2 MDM2 SSB RAD51 PARP1 CDK4 ATR PMC3437743__F1 Glutathione and modulation of cell apoptosis TRADD TRAF2 FADD BAX PMC6798812__F11 Cell Therapeutic Strategies for Spinal Cord Injury CNTF RET NGF GDNF BDNF PMC6651805__F6 Schematic diagram summarizes the mechanism whereby CCN3 promotes Runx2 and osterix expression in osteoblasts RUNX2 CCN3 PMC9353920__F6 Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study IL21R INA SOCS3 DAO LIF APC TRAF3 TNF CASP10 IL23R FOXP3 EDN1 MMP14 AHR TRAF1 RORA TRAF2 IRF4 FADD LAT GATA3 PMC9692260__F3 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical VCAM1 TNF PMC4581604__F9 Diagram summarizing the Rheb-mTOR signaling pathway and findings presented in this study GSK3B IRS1 RHEB PMC9692260__F1 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical NLRP3 VCAM1 APAF1 BAX PMC2846691__F1 Pathways initiated by ACSL, FATP, and ACSBG isoforms PC LPA PMC12084380__F5 Therapeutic strategies targeting immunosenescence ATM TNF FASN PMC12084380__F4 Distinct phenotypic and functional alterations in immune system in aged individuals with sepsis compared with young patients NLRP3 MFN2 CXCL1 TLR4 IKZF1 KLF5 STAT3 PMC12095308__F4 Antiviral type I interferon (IFN) response pathway and known evasion mechanisms of orthohantaviruses TBK1 TLR9 STAT2 IRF7 IRF9 TRAF3 TRAF6 IRF3 IFNAR2 IFNAR1 TRIM25 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 MAVS PMC3111376__F9 Overrepresented miRNA regulatory pathways in PKD PMC9163834__F7 MicroRNA Expression in Circulating Leukocytes and Bioinformatic Analysis of Patients With Moyamoya Disease INVS APC NOTUM SOST CER1 RYK NR1C1 PMC6469018__F3 Signaling pathway of different DCs receptors (CLRs) CARD9 BCL10 SYK PMC12084380__F3 Prematurely aged immune cells during sepsis contribute to immunosuppressive state MREG CD27 CXCR4 IL33 CD80 PMC12084380__F2 Sepsis induces aberrant aging of immune cells which further exacerbates excessive inflammation CASP3 CD14 HEL-S-90n TLR4 ATM CD163 CXCR4 CRP CD40 CD80 SERPINB2 BRD4 PMC3943605__F4 GENETICS AND EPIGENETICS OF ADRENOCORTICAL TUMORS APC LRP5 LRP6 PMC11964413__F7 Proposed mechanism suggests that ABCG8 upregulation in RT-R-MDA-MB-231 cells mediates cholesterol efflux, leading to increased cancer cell progression through the LRP6/Wnt/Beta-catenin signaling pathway in RT-R-MDA-MB-231 cells PLK1 ABCG8 LRP6 FASN PMC9524158__F1 New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival USP14 MYC BAX PMC6474664__F3 Identification of unique pathways after treatment with SC-3–141 TAF11 PRC1 DIAPH2 SLC27A2 APC CENPF HEL-S-66 CENPP LSM12 PMC9476729__F2 Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NFKB pathway activation INS TG NR1C1 PMC8278622__F1 Setting the pick: Can PI3K inhibitors circumvent CDK 4/6 inhibitor resistance? TSC2 GSK3B CCND1 CDK4 PTEN RB1 CDK6 RHEB PMC6348405__F1 Mitochondria-to-nuclear retrograde signaling pathways in mammals KEAP1 ATF4 CA4 PMC3185527__F3 Illustration of the type I IFN signaling pathway and its inhibition by the henipavirus P, V and W proteins STAT1 STAT2 TYK2 IFNAR2 JAK1 IFNAR1 PMC6348405__F3 ATF4 is activated by the perturbation of mitochondrial function MFN1 FGF21 MFN2 ATF4 FXN COX10 SESN2 ALDH2 PMC6348405__F2 Activation of MRS reconfigures mitochondrial metabolism in yeast MKS1 CDH2 HEL60 PMC6348405__F5 Growth signal activates ATF4 and mitochondrial metabolism TSC2 TSC1 ATF4 EIF2A GSK3B EIF4E PMC6348405__F4 ATF4 regulates the serine synthetic and mitochondrial Folate-mediated 1C metabolism pathway CTH PSAT1 PSPH HEL-S-51e MTHFD2 PHGDH PMC9409897__F5 Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability of Cordyceps militaris C6 TG PMC6348405__F6 Cooperative gene regulation for mitochondrial quality control by Nrf2 and ATF4 PINK1 PSAT1 ATF4 ASNS TRIB3 HEL-S-51e MTHFD2 PMC4267896__F3 Central LepRb expression sites and related neuronal circuits POMC AgRP NTS ARC SCX PMC7936166__F7 Relationship between AMPK signaling pathway and lipid metabolism in laying hen hepatocytes HNF4A NR1C1 PMC6798326__F9 TSHR mediated signaling induced OF proliferation through Akt signaling and induction of miR-146a and miR-155 ZNRF3 TSHR PTEN PMC9266727__F1 State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan FECH HEL-S-10 GCLC GPX2 SLC40A1 HEL107 TERT PMC1965265__F6 A schematic representation of differential testosterone action on morphoregulatory gene expression in the rat VP and LP lobes FGF10 SHH BMP7 NKX3-1 BMP4 PMC5530849__F4 KEGG pathway of apoptosis.Notes: The red-colored genes are differentially expressed genes enriched in the pathway in the study GNE NGF TRADD HEL-S-11 CAD TRAF2 HRK PMC6721055__F1 SUMO conjugation/deconjugation cycle SUMO3 SUMO2 CS DES SUMO4 SAE1 SUMO1 PMC9656535__F5 Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight CDK2 CCND1 CDK4 CDH2 PMC4703831__F3 Genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia SUMO3 HSP90AB1 HNRNPL EZR WT1 MMP2 TIMP3 THBS1 ACTN4 ARAF NTRK2 HSPA4 CLIC1 EGR1 YBX1 CXCL10 DDX3X ENO1 HLA-A MBTPS1 IGF1 HEL-S-269 FHL2 MSLN HEL113 TRIM28 MCL1 CAPRIN1 SUMO1 STAT3 COL4A1 PMC6721055__F3 SUMOylation regulates gene expression during Acute Myeloid Leukemia (AML) response to chemo- and differentiation therapies SAE1 DDIT3 TF PMC3604032__F1 PI3K/Akt/mTOR signaling in breast cancer TSC2 TSC1 GSK3B PTEN IRS1 RHEB PMC1885837__F6 Obstructive nephropathy: insights from genetically engineered animals PLG SMAD2 SMAD4 ARHA PMC9289165__F2 Targeting CD47 as a Novel Immunotherapy for Breast Cancer SIRPA CD47 PMC5391045__F2 Heart Failure in Pediatric Patients with Congenital Heart Disease GPC3 NODAL MYL2 ACTN2 MAP2K2 DES DSC2 LMNA HRAS TTN NR2F2 PLN PKP2 JUP TCAP DSG2 HEL114 PMC5710859__F1 Molecular insights into desmoid tumors APC FAP GSK3B TCF4 HES1 PMC9234166__F1 Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy COX7A1 CBR4 ACAD10 GPX4 NDUFS6 FDX1 UQCRB GPX1 BDH1 COXFA4 TG NQO1 HEL-S-2a HSDL2 HEL-S-165mP NDUFB8 ACADS PDHA1 XDH HEL-S-133P RTN4IP1 SDHA PMC7241359__F1 Methotrexate has been recognized by the World Health Organization as an ‘essential medication’, principally due to its broad diversity of mechanisms of action RFC1 TH HMGB1 TLR4 DHFR TYMS HEL-S-70p ACE2 PMC3586519__F1 Schematic illustrating the cancer utilization of the metabolic pathways HEL-S-133P PMC11808587__F2 The role of mGlu5 activation in neuropathic pain CXCL10 CCL2 TRPA1 TRPV1 PMC8717973__F4 Conversion of PanAms into CoA antimetabolites PPCS PPCDC PMC4182169__F2 Nutrient-induced cell proliferation in the crypt BMI1 GPR49 PMC5102139__F8 Pathway map of NOD-like receptor signaling in independent JU-RME NAIP FES NOD2 PMC3935732__F4 Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors CXCR4 SRC CRKL STAT3 PMC11201989__F8 Working model for PD-L1 in the regulation of ciliogenesis RAB8A BBS5 GLI3 IFT140 IFT20 PMC2290973__F2 Pathway Studio diagram of common regulators of differentially expressed genes F2R KDR EP300 STAT2 SAG PLG NCAM1 SOS1 MEF2C tal-1 CDC42 PMC1140402__F2 The central carbon metabolism of E OGA CIT MAL PMC7050137__F3 Different epigenetic signaling pathways regulated during TGF-Beta-induced EMT HMGA2 SETDB1 ZEB2 GAS1 JARID2 EZH2 HDAC1 KDM6B EED PMC6164406__F1 Toll-like receptor (TLR) 4 signaling pathway TLR4 TRAF3 TRAF6 IRF3 MYD88 TIRAP PMC7464074__F1 HER2 signaling pathway, mechanism of action of targeted therapies, and resistance mechanisms IGF1R PTEN MTOR PMC3543090__F8 Model showing the effect of miR-182-5p on the DNA repair pathway CHEK2 RAD17 SMARCD3 CDKN1B ATF1 BRCA1 TP53BP1 PMC2855646__F7 Summary of biosynthetic pathway for O-mannosyl glycans on A dystroglycan in mammals POMT1 POMT2 PMC3543090__F4 MicroRNA-182-5p targets a network of genes involved in DNA repair HDAC3 BTRC HEL2 ATF1 CCNH POLL TLK2 RB1 TOP2A TFDP1 RBBP8 TP53BP1 CDK7 CDK6 CHEK2 ATM SMARCD3 HUS1 CCND1 CDK4 MSH2 POLI CREB5 RAD1 CDKN1B SKP1 BARD1 GADD45A CDC25B CHEK1 BRCA1 CDKN1A RAD17 CDK2 TUBG1 ATR HEL-S-93 SKP2 PMC9244687__F2 Prolactin: The Third Hormone in Breast Cancer SRC PRL PMC8399337__F1 Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities SMAD2 EGFR GSK3B SMAD4 IL6 IL1B PMC7812236__F1 Notch signalling pathway MAML1 MYC HES1 PMC7528681__F1 WNT Signaling in Lung Repair and Regeneration ZNRF3 NLK RNF43 APC LRP5 LRP6 ARHA RAC1 JUN CDC42 PMC7140873__F2 Analysis of different miRNAs families and their target genes implicated in the regulation of flower induction MYB ARF4 ARF3 PMC5040924__F12 Activation of NFKB and STAT signaling pathway STAT1 CD14 JAK1 IL1B IFNG PMC11703395__F5 Advanced whole transcriptome sequencing and artificial intelligence/machine learning (AI/ML) in imiquimod-induced psoriasis-like inflammation of human keratinocytes MHC2TA MAP2 FOS BCL2L1 IL6 MTOR GAST TAPBP IFNG CCKBR PSMB6 MAP2K1 CDKN1A CISH HEL-S-269 PTPN1 PTPN11 PTPN6 RAF1 PSMB9 JUN PSMB8 PMC8484301__F4 Novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway TBK1 CGAS TLR5 TLR4 TLR9 IRF3 XPA MYD88 MAL PMC6831300__F8 Hypothetic model of signaling pathways involved in the differentiation of hiPSC-CM from mesodermal progenitors APC GSK3B PMC6580993__F9 Simplified signaling pathway: this simplified signaling cartoon encompasses all significant molecular changes detected in this study in spleen, hippocampus, and plasma after PEA treatment (PEA/sal) IL18 GPR55 CRH NR1C2 LPA SKI MAPK11 BDNF IL1B NR1C1 GLA PMC8215363__F2 Reversing Post-Infectious Epigenetic-Mediated Immune Suppression HMGB1 SOCS3 HDAC3 CXCL10 RELB TRAF6 IRF3 MYD88 TNF IL1B SIRT1 SOCS1 PMC7792133__F3 PI3K-AKT-mTOR inhibitors and CDK4/6 inhibitors orchestrate multiple effects on immune cells in the tumor immune microenvironment CDK4 MTOR CDK6 PMC5650615__F1 Simplified scheme of innate immune recognition mediated by PRRs NLRC4 IRAK1 TRAF3 TRAF6 IRF3 NOD2 NLRP3 TLR4 NOD1 AIM2 IL1B TIRAP MAL PMC7557148__F2 Some key events during early embryogenesis in Arabidopsis PIN1 MAX ARF5 PMC8235365__F10 Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction TLR4 CD80 CD69 PMC5076471__F1 Inositol pyrophosphates and their corresponding bisphosphonate analogues IP6K1 IP6K3 IP6K2 PPIP5K1 PMC11821611__F4 Biosynthetic pathway of flavor in fresh C PIG59 CS OGDH HEL-S-162eP PMC5041197__F7 CD95-mediated cell migration occurs through a Bcl-2/BclxL/VDAC1/MCU-driven mitochondrial calcium loading BAD EGFR MCU ORAI1 HTRA2 FADD STIM1 BAX PMC3185727__F1 Illustration of the endogenous RNAi pathway and therapeutic mimics AGO2 DGCR8 DROSHA PMC8571891__F1 Oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer EGFR GRB2 MTOR PMC2849133__F4 Main targets of RhoA and ROCK, involved in organization of the cytoskeleton LIMK2 GFAP ARHA PMC11132832__F5 Hub target-pathway network (67 nodes and 95 edges) TH TGFB1 IFNG PMC5286800__F4 Summary of DNA damage-induced breast cancer by estrogen and stressors ATM MDM2 PMC4339278__F1 Inflammasome activation and cross-talk between endothelial cells (ECs) and macrophages (MØ) in atherogenesis NLRP3 VCAM1 LDLR MYD88 IL1B CD36 PMC3361414__F5 Schematic representation of the interplay of T7 gp5.5, gp3, E GP5 SSB GP6 PMC8892214__F2 Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review EPOR EPO NRF1 BCR REST MTOR SIRT1 GATA1 PMC6994496__F7 Proposed new pathway that operates upstream of the CRL2VHL complex and involves the UBXN7 cofactor protein and its regulation by mitochondrial MUL1 E3 ligase UBXN7 ELOC VHL MUL1 RBX1 PMC4452181__F4 Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing PDX1 BACE1 BACE2 INS GCK MNX1 ONECUT1 NKX6-1 NR2A2 HES1 PKLR APP FOXA3 NEUROD1 APOE SNCA TNF TCF2 PAX4 IAPP MAFA FOXA2 CASP3 NKX2-2 NEUROG3 HNF4A PSEN1 PSENEN MME HHEX PMC4081668__F2 Nuclear export of hepatitis B virus mRNAs MYD88 HEL-S-162eP PMC11324288__F1 SLC44A2 mediates the VSMC phenotypic switch in aortic aneurysm ITGB3 RUNX1 ACTA2 SMAD2 NRP1 KLF4 TAGLN PMC4490046__F3 Cell Signaling and Transcription Factors Regulating Cell Fate During Formation of the Mouse Blastocyst CDX2 GATA6 GATA3 PMC7582278__F6 Ingenuity Pathway Analysis (IPA) prediction network of miR-342-3p/-5p and cardiovascular disease VEGFC PI3 IKBKG SFTPA1 PMC8198482__F2 Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis LDLR ABCA1 APOE HMGCR PMC2808370__F7 Possible mechanism by which Wnt determines the specificity of signalling pathway WNT3A APC LRP6 RHO DKK1 PMC11099600__F4 KEGG Pathway Analysis of ultravist-treated mast cells FLCN GSK3B RNF152 PTEN RHO TNF MTOR DEPTOR RHEB MAFK SLC3A2 GRB10 SKP2 PMC6853184__F5 Pathway enrichment analysis of primary human lung cell secretory proteins with decreased abundance in response to PC CTSS ADAMTS5 PLG ADAM15 MMP19 MMP9 CD44 MMP15 ADAMTS6 NID1 MMP3 MMP7 ADAMTS4 MMP14 MMP12 MMP2 CTSC ADAM10 ELANE EMP1 PMC4770149__F1 Developmental pathways are frequently activated in cancer RBPJ APC SMO PMC4821826__F4 BCR signaling pathway is the top-ranked network with increasing association with HuR in response to NS3/4A overexpression BAD PTEN MTOR BTK FYN BCR BASH ZNF423 PTK2B JUN CD19 APBB1IP EGR1 RUNX3 HCLS1 TCF3 RUNX1 CSK CD79B FOXO1 CD79A CARD11 LCK LYN GRB2 SYK MEF2C CDC42 PMC6683584__F8 The mechanism of Notch1 signaling and CXCL12/CXCR4 axis in GICs self-renewal, invasion and tumor growth RBPJ CXCR4 NOTCH1 CXCL12 MTOR PMC6610018__F5 Association of cGAS-cGAMP-STING signaling with apoptosis TBK1 CGAS IRF3 BAX PMC6610018__F4 Cross talk between the cGAS-cGAMP-STING pathway and autophagy/mitophagy TBK1 PINK1 CGAS ULK1 SQSTM1 OPTN PMC9682817__F4 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 SMAD4 SMAD1 PMC9682817__F3 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 APC LRP5 LRP6 RAC1 PMC8914548__F11 TFPI2 suppresses the interaction of TGFB2 pathway regulators to promote endothelial–mesenchymal transition in diabetic nephropathy SMAD2 SMURF2 TGFBR1 TGFBR2 SMAD4 PMC9410841__F11 Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice NLRP3 TXNIP IL6 PMC9707336__F6 M6A methylation profiles of immune cells in type 1 diabetes mellitus CD14 BAD CD37 TRADD DAO PTEN TNF NLK MAX MDM2 GRB2 CYC1 SYK ECSIT RAF1 TRAF2 RBL2 CD19 PMC9707336__F5 M6A methylation profiles of immune cells in type 1 diabetes mellitus CD14 NLK KL DAO MAX TRADD FLNA IRF9 TNF GRAP PMC5159669__F7 Proposed models of two separable mTORC1 pathways TSC2 FLCN TSC1 RHEB PMC7503842__F2 Aberrant Wnt signaling favors disease progression in leukemia COX2 CD27 TNLG8A FOXM1 CD82 MSC SIX1 CDH2 AXIN2 MTOR BMP4 PMC7503842__F1 Wnt signaling pathways NLK APC GSK3B LRP5 LRP6 ARHA RAC1 JUN PMC9552419__F9 SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain CCL11 CCL7 CCL4 CCL2 TRPV1 CCL3 PMC8743668__F2 Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma LRP6 CDK8 STAT3 PMC6273223__F2 Genistein (0.01–10 μM) stimulates breast cancer cell proliferation acting through the classical genomic ER pathway and/or through the fast, non-genomic GPER1-mediated pathway EGFR HBEGF GPER PMC7243790__F3 Chloroquine (CQ) and hydroxychloroquine (HCQ) suppress DNA sensing by the cGAS-STING pathway and Toll-like receptor (TLR) signalling TLR9 IRF7 IRF3 IL6 TNF AIM2 IL1B PMC8906734__F1 FKBP51 associates with amino acids and polyamine biosynthesis pathways TSC2 TFEB RHEB PMC4134342__F2 Sortilin, a novel APOE receptor implicated in Alzheimer disease LDLR APOE PMC3716523__F4 TGFB signaling pathway SMAD2 SMAD4 TF PMC7662576__F4 Host targeted drugs with potential use for Coronavirus disease-19 and their proposed mechanism of action CD14 JAK1 MTOR PMC4470864__F6 Pentose phosphate pathway (PPP) is associated with several cancer- and cell-proliferation-related signalling cascades TIGAR ATM F2 PMC5023176__F13 Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis STAT1 PMC2786808__F8 Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice TSC2 TSC1 APC PTEN MTOR PMC4092039__F2 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin LATS1 RHO LATS2 PMC4092039__F1 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin AMOT CRB3 SCRIB LATS1 LATS2 PMC6933613__F8 Schematic diagram of IL-17A induces excessive autophagy via Src-PP2B-mTOR pathway in neurons under ischemic condition PLCG1 SRC MTOR IL17RC PMC8284339__F4 Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence IL10 CCL8 TNFRSF14 CXCL10 CCL21 CXCR5 IL24 CXCL3 CXCL2 PPBP TNLG7A TNFRSF9 TNFSF10 TNFRSF18 CCL17 CXCL9 IL15RA CXCL11 PMC3045562__F1 Neural pathway for habituation in response to odors TG PMC3036164__F8 Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis EDN1 EDNRA EDNRB HAND2 PMC8796266__F1 Therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition CXCL13 BTK CCL26 BCR CXCL10 LYN CXCL9 EIF4E MTOR CXCL11 PMC3228010__F1 Signaling pathways of sunitinib and sorafenib cardiotoxicity BAD EEF2 RAF1 MTOR BAX PMC2939393__F1 The Fe-S biogenesis proteins, ISCA and C1orf69 (Iba57 homologue), may impact heme synthesis by affecting the production of succinyl-CoA, a substrate of heme synthesis PDC FECH FES ALAS2 PMC8371345__F1 Thyroid hormones and the potential for regulating glucose metabolism in cardiomyocytes during insulin resistance and T2DM PC CD36 HEL-S-5 PMC3204078__F5 SHP-1 activation and modulation on ghrelin signaling to Akt RICTOR MTOR MLST8 PMC3503557__F5 Network and pathway structure for biologically informative priors in the cancer drug response data study BAD ERBB2 CDK2 CREB1 SRC CDC2 MTOR SHC1 BRCA1 PMC10940682__F6 N-myristoylation is involved in the regulation of multiple cellular signal transduction pathways PLCG1 APC IRF3 MYD88 MTOR NMT1 NKD2 BTK TLR4 BCR LCK LYN ZAP70 LAT PMC10940682__F8 S-prenylation is involved in the regulation of multiple cellular signal transduction pathways TIAM1 RIN1 GRB2 RHO MTOR MAVS RHEB CDC42 MLST8 PMC3598339__F4 Network related to cell cycle and cell death in islets cultured at 23 mM glucose concentration MPO NPM1 MYC KLF10 HMOX1 HEL-S-104 PRNP NTN1 APP CD55 CASP8AP2 TJP1 STAT2 LCN2 CYB PHGDH NINJ1 PEMT ADNP UBQLN2 LIPE QK3 TPP2 EP300 ELF3 SDC4 BCL2 ADAM10 FADD CASP4 PMC7287162__F7 Key components of the melanogenesis signaling pathway MC1R SOX10 PMC6933397__F5 Molecular mechanism by which NKILA regulates osteogenesis HDAC2 PMC10940682__F4 S-palmitoylation is involved in the regulation of multiple cellular signal transduction pathways RORC CGAS AGK EGFR APC LRP6 SCRIB IRF3 PTEN HRAS PCSK9 GRB2 STAT3 PMC8236581__F1 Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation APC LRP5 LRP6 ARHA PMC6118308__F1 Progression and environmental sensitivity of C EGF EML1 EGFR GRB2 PTEN PNP INSR HOXB5 PMC3938256__F1 Genetics of lymphatic anomalies IKBKG HGF FLT4 PTEN PROX1 SOX18 MTOR FOXC2 CCBE1 KIF11 GATA2 VEGFC RAF1 PMC12065391__F2 Inflammatory signaling pathways involved in MDS and associated therapeutic targets NLRP3 CD33 IRAK1 S100A8 IRAK4 S100A9 MYD88 TLR1 TIRAP GSDMD PMC4871122__F1 Copper transport and regulation in Schizosaccharomyces pombe COX17 SCO1 HEL-S-44 PMC7057456__F3 Visualization of identified KEGG Cell Cycle pathway routes E2F4 APC SMAD4 ORC3 CDK7 CDC45 ORC2 CDC20 SMC3 CDK2 MDM2 RAD21 PCNA SKP2 PMC5067249__F1 Schematic representation of the classic, alternative, and neural cholesterol clearance pathways of bile acid synthesis CYP27A1 CYP46A1 CYP8B1 CYP7B1 CYP7A1 PMC4433279__F4 Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma PTEN MTOR ROR1 PMC2672887__F1 Model for the regulation of type 1 interferon signalling by filamin B ISG15 RAC1 PMC3598339__F3 Network related to lipid metabolism in islets cultured at 23 mM glucose concentration ALDOB BAD PCSK7 HEL-S-1 PARD6B HEL-S-104 NR1C1 BCL2L2 LIPE BCL2 SFRP1 HMGN1 PPARG CYFIP1 APOA2 BCAP31 PARD3 CYCS CDC42 BAX PMC5795989__F1 BMP-triggered signalling pathway and major regulators BAMBI HEL-S-28 SMURF2 SMAD6 SMAD4 RHO SMURF1 SMAD1 TF DKFZp781O1323 PMC3598339__F2 Pathway analysis identifies a network of genes related to lipid metabolism in islets cultured at 5.6 mM glucose concentration SNAP91 PTN AACS ACSS2 SGTA TCF12 PTEN TNF HEL-S-104 CDC34 WNT10B STARD4 ATP6V1E1 PCSK9 TMEM97 PMVK INSIG1 EP300 SCD SREBF2 PMC6915017__F6 CD28 regulates blast thoracic exposure-induced oxidative stress and apoptosis in brain tissue in mice via the PI3K/Nrf2/Keap1 signal pathway HEL-S-44 IL1B PMC3370396__F6 NSAIDs perturbed genes related to thrombosis, fibrinolysis, and PAR signaling PLAT PLG APC TF PMC7023504__F5 Mitochondrial redox signaling as essential part of branched-chain keto-acid- stimulated secretion of insulin MCC IVD HEL-S-44 PMC10525998__F10 Transcriptomic Analysis of Light-Induced Genes in Nasonia vitripennis: Possible Implications for Circadian Light Entrainment Pathways CRY2 NPAS2 PMC7251695__F1 LncRNAs regulate chemoresistance through apoptosis MTOR FADD PMC8647006__F1 Regulatory switches, reinforcement, and redundancy in DSB repair pathway choice RNF168 RNF8 BARD1 BRCA1 SMARCAD1 PMC6468910__F4 ER stress and chemo-resistance: Role of inositol-requiring enzyme 1 alpha (IRE1), activating transcription factor 6 alpha (ATF6), and glucose-regulated protein 78 (GRP78) BAD BIK CDK4 MTOR PDIA5 CDK6 PMC7251695__F3 LncRNAs regulate chemoresistance through cancer cell stemness SOX2 KLF4 SOX9 PMC7014277__F3 Role of protein phosphatases in the DNA damage checkpoint deactivation PLK1 ATM ATR H2AX PMC5617549__F1 Molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer F2 PFKFB4 PMC5617549__F3 The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer SLC2A3 MAPK14 HIF1A PMC6815035__F5 The miRNA–mRNA interaction networks containing eleven lipid metabolism or deposition related pathways FADS2 PRKAA2 ELOVL1 SI PRKAG2 PLD4 ACOX1 CAMKK1 PMC2853417__F5 Differentially expressed genes in the TGFB signaling pathway RUNX3 NR1i1 TLX2 NODAL RUNX2 BMP2 GSC PMC6815035__F7 MicroRNAs and their regulatory networks in Chinese Gushi chicken abdominal adipose tissue during postnatal late development MYLK2 PDGFRA PMC6815035__F6 MiRNA–mRNA interaction networks containing five cell proliferation and differentiation related pathways FST ERBB4 PDGFRA PRKAA2 BMP5 PRKAG2 KLF2 NTRK2 SGK1 PMC7540151__F2 Apoptosis by miR-187 LEF1 CYP1B1 BCL2 AXIN2 DKK2 CRMP1 FGF9 BCL6 PMC6696099__F1 Proposed targeting approaches involving ACSL isoenzymes in cancer FACL4 ACSL1 ACSL3 HEL-S-5 PMC9273593__F6 Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications CXCR3 CXCL1 HGF IL1B GLS PMC7540151__F3 EMT by miR-187 PTK6 SMAD2 ZEB2 S100A4 NT5E SOX4 PMC5799178__F7 p38 mediates the transcription and the translation of E-selectin by modulating miR-146a and miR-31 TRAF6 IL1B GATA2 PMC7762471__F7 Mechanism underlying ISO’s anti-HCC effects MTOR DKFZp686F0183 BAX PMC6219034__F10 PRRSV-induced G2/M cell cycle arrest in MARC-145 cells WEE1 CCNB1 MYT1 PMC5487699__F2 Regulation and execution of the autophagosomal-lysosomal degradation pathway PINK1 LRRK2 ATG12 ATG3 ATG10 DKFZp686F0183 PMC8767971__F1 COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway PIK3R1 NGF KEAP1 F8 MAPK3 ALB CXCL8 CREB1 CCL5 BCL2L1 CCL2 MYD88 IL6R HMOX1 GGPS1 STAT1 ADAMTS13 FDPS CASP9 CSF2 NTRK2 PLG FOS CXCL10 VEGFA MVK IFNAR2 CEBPA TNF IRS1 HMGCR PMVK MVD FDFT1 GRB2 BCL2 IL2RA BDNF SIRT1 TGFB1 IFNA1 KLK4 CSF3 INS MX1 SERPINC1 ISG15 OAS1 BTK PLAT IL18 OAS2 TLR7 TLR4 F2 F3 IL17A IL2 KNG1 IL4 IL1B JUN IL10 SQLE PF4 FGF2 MMP9 PTGS2 NFE2L2 NR3C1 IFNB1 IL6 CD8A HEL-S-162eP CASP3 NFKBIA JAK1 PPARG CYCS CCL3 PMC2853417__F7 Differentially expressed genes in the estrogen receptor signaling pathway CARM1 HDAC3 PELP1 TBP IGFBP1 NR0B2 DDX5 PMC5355296__F2 Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase EGR1 ATF3 GADD45A TXNIP IL6 CREB5 PMC2853417__F6 Differentially expressed genes in the ERK/MAPK signaling pathway STAT1 PIK3CD MOS GRB2 RAPGEF4 CRK PMC2873055__F9 ACBD3-mediated signaling pathway and cellular regulation NUMB PRKAR1A ACBD3 PBR PMC7905525__F2 Signaling pathways associated with AQP5 in cancer AQP5 SMAD2 EGFR PMC10179314__F1 PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis EGF HGF EGFR VHL MTOR PMC5840025__F9 Cell-specific requirements for STAT proteins and type I IFN receptor signaling discretely regulate IL-24 and IL-10 expression in NK cells and macrophages STAT1 STAT4 STAT3 PMC10885697__F2 MAPKs signaling is obligatory for male reproductive function in a development-specific manner EGFR SRC PMC12056752__F1 RAS signaling pathway involves small GTPase switch proteins, NRAS, and KRAS NF1 GAB2 GRB2 CBL PMC12056752__F2 MicroRNA Signatures: Illuminating Minimal Residual Disease Monitoring in Juvenile Myelomonocytic Leukemia - A Review AGO1 AGO2 RAN PMC4524120__F10 Proposed mechanism for the male-specific heart phenotype in insulin-resistant Pcyt2+/− mice PC PCYT2 CD36 PMC7900570__F1 Growth Hormone Signaling Pathway with highlighted Glucose Uptake micropathway STAT1 IGF1R IGF1 IGF2 GHR PTPN6 IRS1 STAT3 PMC7900570__F2 Node activation of Growth Hormone Signaling Pathway for gastric cancer sample GC.11_S19_R1_001 from STAT1 IGF1R IGF1 IGF2 GHR PTPN6 IRS1 PMC8403095__F7 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation LCK ZAP70 GRB2 LAT PMC11731478__F1 Metabolic pathways of riboflavin in E RPIA TNLG7C PMC8403095__F1 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation TLR4 BCL10 BCR IRAK1 IRAK2 IRF3 IRAK4 MYD88 IL1B FADD MAVS MAL PMC5905998__F1 Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways PAICS HEL-S-70p MTOR ASL PMC7824032__F1 Methylglyoxal and methylglyoxal pathway in cell response to oxidative stress GLO1 MAL HEL-S-162eP PMC8819539__F1 Periodontal Ligament Stem Cell-Derived Small Extracellular Vesicles Embedded in Matrigel Enhance Bone Repair Through the Adenosine Receptor Signaling Pathway FGF2 BCL2 PCNA PMC9563402__F2 MAPK Signaling Pathway in Oral Squamous Cell Carcinoma: Biological Function and Targeted Therapy CXCL1 EGFR CXCL2 MAP3K7IP1 JUN PMC9602304__F2 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches ULK1 ATG16L1 ATG12 ATG3 ATG101 ATG10 MTOR PMC9602304__F1 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches AGO2 DROSHA MT4 RAN PMC10178712__F5 RNA-sequencing analysis revealed the role of trimethylamine-N-oxide (TMAO)-mediated signaling in vascular dementia MMP3 WNT9B opn S100A8 LCN2 CCL4 CCL2 ATP2A1 CYBB PMC3749870__F10 CD25 and CD69 induction by A4B1 outside-in signalling requires TCR early signalling complex proteins LCK VAV1 LAT CD69 PMC6509174__F6 Wnt/Beta-catenin signaling pathway regulated by PARG gene silencing during BaP-induced lung cancer APC GSK3B PARG PMC6375548__F6 Alternative (backdoor) androgen production and masculinization in the human fetus HSD3B1 CYP11A1 HSD3B2 SRD5A2 HSD17B3 AKR1C2 CYP17A1 PMC4801721__F1 Methionine cycle and transsulfuration pathway HEL-S-61p PMC3751638__F3 METH-regulated genes in METH-pretreated rats AMOT PGR MYCBP S100A2 JAM3 HSF1 UBC RIMS2 FOXA3 NPBWR1 KRT1 IGSF5 PARD3 SPDY1 CLCN1 MMP10 NPB SRPK3 NPBWR2 CEP152 AIP PLG BMP2 CD44 QSCN6 CEP55 LNX2 LAMA3 SPAG5 CPB2 ANP32E NR4A3 IGFBP1 BCL2 STAG3 SERPINF2 HABP2 PLAG1 STAT3 PMC6375548__F1 Alternative (backdoor) androgen production and masculinization in the human fetus HSD3B1 CYP11A1 AKR1C1 AKR1C4 SRD5A2 HSD17B2 HSD17B3 AKR1C2 CYP17A1 HSD17B6 PMC7211589__F1 This figure illustrates the differential glucose metabolism in a healthy macrophage and in a COVID-19-activated macrophage ASMT PDC MTOR AANAT PMC6396666__F3 Protein–protein interaction networks.Notes: Upexpression genes were analyzed and constructed a network BLM CHAF1A TAC3 POLE2 ECT2 STIL CCNB1 KIF15 GINS2 PTTG1 HELLS FOS FGF2 TACC3 RCC1 FBXL7 AURKB SPAG5 UBE2C MCM5 CDC20 IGF1 MCM2 ZWINT MYLK PMC5357538__F2 Wnt, Hedgehog, and Notch canonical signaling pathways IHH SUFU APC TEF SHH SMO PMC6691912__F1 EV production procedure.Exosomes, 50–150 nm, are initially formed by a process of inward budding in early endosomes to form multivesicular bodies CD9 CD63 CD81 PMC2951839__F1 Lower Succinyl-CoA:3-ketoacid-CoA Transferase (SCOT) and ATP Citrate Lyase In Pancreatic Islets of A Rat Model of Type 2 Diabetes: Knockdown of SCOT Inhibits Insulin Release In Rat Insulinoma Cells PC ACAT1 ACAT2 PMC8166871__F7 LIRCP-regulating network that connects autophagy and carcinogenesis NCOR1 KEAP1 UCP1 ALK TBC1D7 SMAD4 CAPN10 MYH1 TRPM8 KL KDR TNFSF12 TPP1 CRTAM TBC1D15 SUPT20H RHOT1 PGRMC1 IRS1 GPLD1 MYH6 TSC2 RICTOR PRKCB HSPG2 PCDH17 UGCG F7 EPHA3 SGPP1 VPS16 TGFBR1 RAB3GAP2 COPA NPEPPS DKFZp686F0183 NOD2 TLR4 RRM2 VPS39 LRRK2 PDGFRA HEL-S-30 SLC16A7 HEL-S-34 ARHA OATL1 IFNB1 PHGDH MAP1LC3C SPG11 SKP2 EXOC2 STBD1 MTMR8 MTMR9 SPHK2 CBFB NLRP3 DNASE2 PIKFYVE PICALM UVRAG HAT1 HEL-S-281 SORT1 PTCH2 ZFYVE26 NLRC4 TECPR1 MAP1S PPP1R13L SNX30 AMBRA1 CYBB IFNAR1 EIF4G1 NAA25 TET2 CLCN3 MTMR3 KIAA0226 GRID2 TECPR2 CXCR4 ENO2 EFL1 SNX4 ATR ATAD3A CHUK BRAF ATG2B PDE5A EGFR PFKM OPTN MTOR RPTOR PLD2 ATM ATG9A PRKDC GABARAP TBC1D17 PRKD3 PFKL DKFZp762B153 SPNS1 TTI1 CACNA1H TP53INP2 PRLR ERN1 ABCC1 MCOLN1 ADRBK1 EPHB2 STAT3 PMC9100033__F1 Disorders of the Calcium Sensing Signaling Pathway: From Familial Hypocalciuric Hypercalcemia (FHH) to Life Threatening Conditions in Infancy CASR AP2S1 GAL PMC4803814__F1 Ras MAP kinase pathway PIK3CD BRAF RASA2 NRAS SHC3 RASA3 RGL3 KSR1 MAPK1 ETS2 RAPGEF2 ARAF JUN RAPGEF1 SOS2 RCE1 FOS HRAS KSR2 SHC2 MAPK13 MAP2K1 RASGRP3 RPS6KA1 ICMT RASGRF1 DUSP16 GRB2 PIK3CA SHC4 RAF1 SOS1 SHC1 RASAL1 RASAL3 RPS6KA2 RGL2 RASGRP4 PMC8495134__F1 Epilepsy in the mTORopathies: opportunities for precision medicine TSC2 NPRL2 TSC1 C16orf35 DEPDC5 TBC1D7 PTEN MTOR STRADA RHEB PMC2645305__F3 Airway Smooth Muscle Growth in Asthma ELF2 TSC2 GSK3B EIF4E MTOR RHEB PMC2276341__F3 Network analysis of target genes SFRP4 Meflin PMF1 PIGC TPO NEUROD2 TCF12 PMC9671114__F6 Changes and significance of gut microbiota in children with focal epilepsy before and after treatment BAD SI NAGA MAL PMC2194080__F1 Proposed mechanism of CD4+ T cell priming after Leishmania major infection EPCAM MYD88 PMC8231510__F3 CUT Domain Proteins in DNA Repair and Cancer NEIL2 LIG1 MPG PMC8231510__F2 CUT Domain Proteins in DNA Repair and Cancer SESN3 KEAP1 GRB2 NOX4 SESN1 PTEN RAC1 PMC7063158__F1 Schematic diagram for T cell activation and mechanism of IP3 activation PC NACA PMC8546182__F1 Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease P2RX7 SDHA PMC3538588__F8 Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes FST NODAL PITX2 SMAD6 SMAD4 SKP1 ARHA RBX1 LTBP1 IFNG PMC3759750__F2 Regulation of prosurvival and apoptotic pathways by ER stress CASP3 EDEM1 ATF4 EIF2A CASP9 TRAF2 XBP1 BAX PMC4455918__F1 mTOR signaling pathway EIF4E MTOR EIF4B PMC86592__F9 LPS-induced signaling pathways leading to activation of transcription and spreading CD14 LBP TRAF6 MYD88 PMC9404696__F7 ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition GSK3B ANGPTL8 PMC3267662__F2 IGF1R-IR/PI3K/Akt/mTOR pathway and its manipulation through diet IGF1R IGF1 MTOR PMC10609794__F2 The PRG4-CD44 axis in mitigating the pro-inflammatory and pro-fibrotic signaling pathways in DJDs NLRP3 SMAD2 CD44 SMAD4 TF PMC208733__F1 Regulation of the Foxa and Foxo transcription factors through PI3-kinase signaling FOXO4 FOXA1 PGC FOXA3 FOXO1 FOXA2 PMC6206292__F3 Diagram of carbohydrate metabolism pathways with their related DEGs (differentially expressed genes) and DAMs CS SI MT1A MIP PMC6206292__F5 Brief diagram of amino acid metabolism pathways with related DEGs and DAMs HEL-S-61p ASMT AFMID AANAT PMC11853609__F9 Schematic model of the mechanism by which PHF8 promotes malignant phenotypes and immune escape of KRAS- or BRAF-mutant CRC cells HLA-A BRAF IRF7 CCL5 IRF-1 HLA-B PMC3731360__F6 Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia STAT1 VAV3 NFATC2 BCR ZAP70 MYC BCL2 CTLA4 PMC6034754__F4 MicroRNA molecular profiling identifies potential signaling pathways conferring resistance to chemoradiation in locally-advanced rectal adenocarcinoma BCR SMAD2 ZEB2 PIR SMAD6 MMP20 ELMO2 BCL6 PMC2438299__F6 Regulation of G1/S transition by the Cdh1/APC-Skp2-p27 cascade in colon cancer Cdh1/APC is critical in regulating Skp2-p27-cyclin E/CDK2 axis, resulting in averting abnormal entry of S phase CDK2 CDC2 SKP2 PMC4725591__F2 BMP signal transduction SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC8239905__F3 COVID‐19‐related coagulopathy: A review of pathophysiology and pharmaceutical management TF PMC7490227__F10 Silencing of S100A4 downregulated the PI3K/Akt/mTOR pathway, enhanced autophagy, and promoted wound healing of rabbit cornea after alkali burn FGF3 MTOR PMC6496459__F3 Differential regulation and effects of glycolysis induction in GM-DCs upon stimulation over time CCR7 CD40 CD80 HIF1A MTOR PMC6496459__F2 Cellular metabolism networks HEL-S-62p PDK3 PDK2 MPC1 PDK4 HEL-S-133P FASN PMC9315842__F2 Ferroptosis defense pathways GPX4 GCLC DHFR DHODH PMC8421956__F3 Basic science of optic nerve regeneration CNTF TSC1 SOCS3 IGF1 LIF PTEN MTOR STAT3 PMC5572616__F1 Effect of the Hh signaling pathway on the regulation of proliferation and differentiation of SSCs in mammals DHH MAX SUFU GDNF PMC8507550__F2 The Hedgehog Pathway in Cholangiocarcinoma PLK2 SOX2 SMO CDH2 PMC8507550__F1 The Hedgehog Pathway in Cholangiocarcinoma SUFU GLI3 SMO PMC11674716__F14 Diagram of red KEGG of Non-alcoholic fatty liver disease SOCS3 PMC11674716__F13 Diagram of red KEGG of AMPK signaling pathway EEF2K PDK2 INS MTOR RHEB CFTR INSR TSC2 HNF4A F2 CIDEA POC1A CD36 PMC11674716__F12 KEGG network diagram of the PPAR signaling pathway UBC PLTP HEL-S-28 LPL CPT2 PMC3551464__F1 Control of cell adhesion during neuronal migration RELN RAP1A ASTN1 DAB1 CDH2 SIAH2 ASTN2 PMC10375449__F8 Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis GPX4 SLC7A11 SLC3A2 STAT3 PMC11674716__F11 WikiPathway outline of burn-wound healing EPO VEGFA ACTA1 HBEGF TNF COL1A1 LAMA1 GJA1 CCND1 PRODH2 NOS2 PECAM1 TGFB1 PMC7791174__F7 Illustrations of TRPV6 as a critical regulator in osteoclastic bone resorption IGF1R IGFBP1 TRPV6 PMC7727543__F1 Key mutations in gene categories represented in MDS/MPN overlap syndromes NF1 RUNX1 ASXL1 PTPN11 TET2 CBL BAP1 PMC6899977__F3 The carcinogenic mechanisms of six major microorganisms TH SMO STAT3 PMC3764601__F4 The meiotic recombination pathway in C SP2 RTEL1 MRE11A SP4 RAD50 RAD51 SP1 SP5 MSH4 SP7 SP3 MSH5 SP9 PMC11839971__F1 circ0066187 promotes pulmonary fibrogenesis through targeting STAT3-mediated metabolism signal pathway BLM RTCA C6 STAT3 PMC11956896__F3 The regulatory effects of PCSK9 in T cells and tumor cells TH PCSK9 TLR4 NFATC1 LDLR PMC7072930__F2 Therapy for fibrodysplasia ossificans progressive (FOP) ENPP2 SMAD4 MTOR SMAD1 DKFZp781O1323 PMC11956896__F1 Mechanism by which PCSK9 regulates lipid metabolism PCSK9 LDLR CD36 PMC4449624__F1 Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome TG UCP3 UCP2 PMC5004130__F6 Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride RELA CRP IL4 CCL1 CP PMC4335171__F1 Death and dessert: Nutrient signalling pathways and ageing IGF1R IGF2 PTEN IRS1 PMC10380638__F5 Schematic presentation of low-dose IR-induced immune effects in the spleen of mice, according to Cho et al IL5 PMC7427859__F5 Differentially methylated genes of mTOR signaling pathway at CG (a) and CHH types (b) FLCN GSK3B RNF152 PTEN RHO EIF4E MTOR DEPTOR IRS1 RHEB TSC2 RS1 RICTOR SESN2 GRB10 SGK1 SKP2 PMC3270467__F1 Putative galanin-mediated neuronal pro- and antinociceptive mechanisms in the dorsal horn of the spinal cord GALR2 GAL GALR1 TRPV1 PMC6294998__F2 New therapeutics based on emerging concepts in pulmonary fibrosis IL10 IL13 EGFR CCL2 CXCL12 TGFA PMC4560409__F8 Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway CD14 TLR4 MMP9 SYK RAF1 IL4 CCL22 PMC5348798__F3 Cdk5 takes part in DDR through STAT3 pathway EME1 CDK5 MYC CCND1 STAT3 PMC8504955__F3 Large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain GAD2 ND4L PFKM HEL-S-32 COX5A COA3 MDH2 ZNF183 NDUFB8 ACO2 OGDH PFKP COA7 SDHA SDHB COX7A1 SDHC NDUFS6 NDUFAF2 ENO1 PFKL IDH3B HEL60 ENO2 COXFA4L2 AGL PMC10892304__F6 Protein–protein interaction (PPI) network in biosynthesis of plant hormones and signal transduction pathways BAK1 EBF2 PMC3867948__F4 Death receptors and the extrinsic pathway of apoptosis TRADD FADD PMC8276676__F3 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma TRAF6 IL17RC PMC10515252__F4 m6A modifications interact with the CRC inflammatory microenvironment SOCS2 METTL3 VEGFA IGFBP2 EPHA2 PMC8276676__F4 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma TRAF6 TNF IL17RC PMC3603502__F10 Redox regulation of signaling pathway leading to T-cell activation/proliferation CCR7 HEL-S-92n LAT PMC9221329__F1 Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review ZEB2 CDH2 TNF STAT3 PMC8230587__F3 The Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease HDAC2 SPHK1 BDNF HDAC1 PHB2 PMC11655208__F4 Circadian regulation of drug response in mental disorders TNC AMH DDC CA13 PPARG CA12 PMC6445936__F7 Highlights of this study FUT8 BCR CD69 PMC9191825__F2 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 JUP FES SKI MAL PMC9191825__F4 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 IL10 CS CFB STAT2 NLRP1 IRAK2 IFNE IL1R2 TRAF6 IRF3 NLRP3 C9 TLR4 CFD C7 IL2RA ACE2 MAVS STAT3 PMC9213771__F7 Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling SGPP1 B4GALT5 GOLPH3 PLPP3 AHR A4GALT UGCG TM9SF2 LAPTM4A TMEM165 SGPL1 SPHK1 CERS2 PMC7137032__F2 Current paradigm of asthma endotypes and related therapies IL33 IL25 TSLP PMC9643007__F10 Stromal contributions and potential therapeutic agents KIT BRAF ATM GINS4 SRC BCL2 GINS3 GINS1 GINS2 MPG PMC3741135__F9 Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction GSK3B SIRT1 PMC9409235__F4 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease MTOR PMC5045425__F4 Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma ACCS BMP3 HLA-G KLK4 FOS PTGS2 TEF TSPAN1 HBEGF JUND CCNL1 TFRC PMC8652287__F2 Biological Adaptations of Tumor Cells to Radiation Therapy EIF2A MPC1 KNS2 SIRT3 PMC8067192__F4 Network analysis performed using ingenuity pathway analysis (IPA) IGF1R MPO FANCD2 C1QTNF4 CLEC3B GSK3B IDO2 CCL2 CLU IFNG APOF SEC16B TCL1A RBP4 NR1H3 APMAP STAR SAA4 HAVCR1 CD5 HPR PS1TP5BP1 ORM2 DBP IGFBP4 SAA2 PMC9409235__F3 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease NLRP3 ULK1 TLR4 TFEB TLR9 NR1C2 TXNIP OSR1 PTEN FOXO1 PMC9409235__F2 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease SQLE FLCN CRTC2 PTEN TG IRS1 FOXO1 FASN PMC7407646__F1 TLR4 signaling pathways activated in microglia during neuroinflammation CASP3 NLRP3 HMGB1 RIPK1 TLR4 RIPK3 TRAF6 MYD88 CASP8 IL1B FADD MLKL PMC11820109__F7 Cdk5-gated light signal GEM CDK5 CRTC1 PER2 SIK1 PER1 PMC7972864__F1 Proposed model of signaling pathway involved in FUC prevented 6-OHDA-induced ROS MAF GCLM KEAP1 GCLC PMC9643775__F2 New insights into iNKT cells and their roles in liver diseases SIRPA CD47 CD40 CD80 PMC3126159__F4 Temporal regulation of apoptosis in SeV-infected cells by PI3K TBK1 APAF1 RIGI IRF3 BAX PMC7429975__F7 Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models TH MAX GEM SMO PMC4386721__F3 Signaling pathway map GSK3B PTEN PMC7744373__F5 Differentially phosphorylated protein Pathway enrichment analysis VASP BAD F2 HEL-S-28 APC INS SHE RHO PTEN HEL114 CRK PXN PMC4490461__F6 Schematic representations of mammalian homocysteine metabolism PMC3229968__F2 Deciphering the role of Nuclear FactorKB in cellular senescence ATM TRAF6 PMC3229968__F1 Deciphering the role of Nuclear FactorKB in cellular senescence RELA LTB RELB MAP3K7IP1 PMC3229968__F3 Deciphering the role of Nuclear FactorKB in cellular senescence TSC2 TSC1 PTEN MTOR SIRT1 RHEB PMC7947273__F4 Life Without Thyroid Hormone Receptor PRMT1 MSI1 GPR49 PMC5664959__F2 Molecularly Targeted Therapies for p53-mutant Cancers EGFR ARHA MTOR PMC6456454__F1 Inflammatory mediatorsA: Inflammatory mediators with mainly proatherogenic effects are mediated by interleukin-1(IL-1), interleukin-6 (IL-6), and tumor necrosis factorA (TNFA) through nuclear factor kappa beta (NFDB) signaling cascade CRP TNF PTX3 PMC3717800__F7 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma VASP BAD BRAF HEL-S-28 SHE ARHA PTEN PMC4013649__F7 A20 on LPS signaling pathway TLR4 IRAK1 TRAF6 CD40 IRAK4 PMC2923453__F1 Molecular Pathways: Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma COX2 SMOX OAZ1 SRM MYC OAZ2 PAOX AMD1 SMS OAZ3 PMC3534787__F9 Vorinostat, an HDAC Inhibitor Attenuates Epidermoid Squamous Cell Carcinoma Growth by Dampening mTOR Signaling Pathway in a Human Xenograft Murine Model PI3 PTEN MTOR PMC4643408__F2 Signaling pathways associated with CRKL, GAB2, and FRS2.CRKL is activated by multiple types of cell surface receptors including integrin receptors upon binding to extracellular matrix (ECM), cytokine receptors, and growth factor receptors EGF HGF FRS2 GAB2 GRB2 CRKL PMC4119864__F3 Signaling epicenters: The role of caveolae and caveolins in volatile anesthetic induced cardiac protection CAV3 CSK SRC PMC7080238__F9 STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection NLRP3 CGAS IL1B PMC8080572__F1 Key signaling molecules in angiogenesis PIGF VEGFC NRP1 VEGFA VEGFB NRP2 PMC10853571__F6 Molecular mechanisms of tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs) and ketamine CAMK4 MTOR BDNF PMC9143160__F1 PD-1/PD-L1, MDSC Pathways, and Checkpoint Inhibitor Therapy in Ph(-) Myeloproliferative Neoplasm: A Review EGF PTEN PMC9515494__F8 Systemic tryptophan homeostasis SLC7A5 IDO1 ULK1 TPH1 SLC16A10 SLC6A19 GPR142 TPH2 SLC3A2 SLC15A2 MTOR ACE2 PMC10853571__F3 Molecular signaling schematic of cytokine hypothesis in the pathogenesis of MDD NLRP3 GSK3B IL6 UCP2 TCF4 STAT3 PMC10853571__F2 The pharmacological mechanism of fluoxetine in astrocytes EGF EGFR SRC PTEN PMC6678550__F1 Potential signaling pathway between expression of bone morphogenetic protein receptor type II, HDL cholesterol, and vascular remodeling in pulmonary arterial hypertension BMPR2 ABCA1 PAH PMC9515494__F4 Systemic tryptophan homeostasis IDO1 HAAO HEL-S-90n KYNU KMO PMC5514982__F1 Caloric restriction, exercise and AdipoR pathway activate AMPK–SIRT1 and PPAR pathways, which may increase longevity in humans MTOR SIRT1 PMC7506548__F2 Non-canonical NFKB pathway TBK1 OTUD7B NLRP12 TRAF3 RELB PELI1 TNF TRAF2 PMC2581770__F3 TNFR and LTBR signaling pathways for NFKB activation RELA RELB LTBR PMC7506548__F1 Activation and regulation of canonical NFKB pathway TRADD IRAK1 TRAF6 IRAK4 MYD88 TLR3 TLR4 BCL10 TRAF5 TRAF2 FADD TIRAP TAB3 PMC7457231__F3 SMAD cooperation with different DNA binding partners NODAL SMAD2 SMAD4 GSC MIXL1 LATS1 LATS2 FOXH1 PMC4673661__F1 Osteocytes and Skeletal Pathophysiology SOST TRANK1 PMC7457231__F6 Cancer cells can traverse the tumor suppressive TGFB bottleneck by accumulating mutations (“X”) that disable the signal transduction pathway ANGPTL4 CXCR4 PMC7457231__F5 Determinants of TGFB tumor suppression and its subversion in cancer KLF5 SMAD4 SOX4 PMC8205588__F1 Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria GPX4 STEAP3 PMC7982543__F3 Pathological pathway of “Lipid-toxicity Inflammation” or “Dampness-heat Syndrome”—Insulin Resistance-Metabolic disease TLR4 UNK IL1B PMC5691648__F6 Predicted pathways deregulated during ZIKV infection CANX AMFR ATF4 EIF2A HEL-S-99n BCL2 SCEL VCP TRAF2 XBP1 PMC7457231__F1 TGFB–SMAD pathway in the basal and activated states SMAD4 CDK9 CDK8 PMC8558661__F10 Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-Alpha-activated COX-2-cPLA2-PGE2 Pathway CLC GC DKFZp686F0183 BAX PMC8877534__F9 Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/Beta-Catenin Signaling Pathway GSK3B LRP5 LRP6 CDK4 PMC3878444__F3 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro BAD IL13 IRF-1 CSF2RA PMC5640981__F3 Thyroid C-Cell Biology and Oncogenic Transformation TSC2 BAD TSC1 GRB2 CASP9 SHC1 RHEB PMC3878444__F2 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro ENPP1 TNIP3 CFB TRIM6 WTAP DKFZp686L24211 GLRX PPIF ZMYND11 SDC4 PIM3 JUNB SLC11A2 IRAK3 JUN ERC1 PMC3878444__F4 Upstream regulators and their target molecules in datasets as identified by Ingenuity Pathway Analysis (IPA) CCR5 MARCKS BTG3 SAMSN1 CCL5 CDK6 SELL BIRC3 CCR7 RGS1 CD40LG NOS2 IL4 PSMB9 IRF-1 IL1B IL10 IL13 FOS CDKN1B CXCL2 IFNB1 TNF BIRC2 NFKB1 CCL20 CD40 SNX4 TNFAIP3 PSMB10 PMC3157228__F7 Scheme for changes in the molecular pattern of inflammatory signaling, antigen processing, and presentation in attacked myofibers STAT1 MHC2TA IFNGR2 IFNGR1 PSMB8 PMC5035969__F1 Schematic presentation of the N-linked core oligosaccharide structure EDEM1 EDEM2 EDEM3 PMC10419312__F3 Agents to target macrophages in CTD-ILD IL33 SMAD4 S100A4 PMC10419312__F2 Macrophages in CTD-ILD CCL2 CCL18 TNF SDC2 PMC3878444__F6 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro TREM1 CD40 NOD2 PMC5563070__F6 Cell type-specific metabolism of T INS CIT MAL PMC9105721__F1 Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity POMC NPY AgRP MC4R NPY5R MC3R PCSK1 LEPR PCSK2 PMC7065375__F7 Part of the KEGG pathway “Focal adhesion” VASP BAD FYN HEL-S-28 GRB2 SHE ARHA PTEN CRK JUN PMC3717870__F4 Analysis of gene transcription in response to an acute bout of exercise identifies dysregulation of SMAD, CREB, and HDAC activity in LRT CSRNP1 MXD1 SERTAD1 ATF1 CREB1 POR FSTL3 ANKRD1 GADD45B EYA1 PPARGC1A SFRP1 SEMA3C BTG2 TPSAB1 RHOB HSPA4 EGR1 MIDN NAB2 SKIL FOS ATF3 HBEGF GADD45A DDIT3 SPRY2 CDKN1A EGR2 NR4A3 BCL2 PMC8745251__F1 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles CYP27A1 CYP8B1 AKR1D1 AKR1C4 CYP7B1 CYP7A1 HSD3B7 PMC8745251__F2 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles ABCG5 FGF19 FGFR4 CYP7A1 PMC7210752__F1 Proposed model for the regulation of pistil growth and ovule primordium initiation PIN1 BIN2 RGL2 PMC8650509__F1 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease SNCA PINK1 RAC1 PMC8650509__F4 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease NOX3 DUOX1 DUOX2 NOX4 DUOXA1 NOX5 DUOXA2 NOXA1 PMC4812115__F5 Most correlated signaling pathway was the rheumatoid arthritis pathway (http://www.kegg.jp/kegg-bin/show_pathway?map05323) CTSL CTSK CXCL2 IL6 IFNG PTER PMC8296592__F8 EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/Beta-catenin signaling RUNX2 BMP2 VEGFA EGFL6 PMC3521791__F6 Part of the top canonical pathway affected by in vivo LPS administration into the human lung TLR9 IRAK1 IRAK2 MAPK3 TRAF3 MAPK14 CREB1 TRAF6 IRAK4 MYD88 MAP2K6 DOK1 MAPK1 FLII MAP3K1 TRAFD1 IRF7 IRF3 TNFAIP3 IRAK3 TNIP3 MAP2K4 TICAM2 MAP2K3 NOD2 TICAM1 TLR8 BTK RIPK1 TLR7 TLR4 NOD1 TRAM1 IL1RL1 JUN CD14 TLR5 NLRP12 CD44 MAP2K2 TLR1 TLR10 TLR3 MAP2K1 NFKB1 RELA LBP RAN TIRAP TRAF4 SOCS1 PMC6497364__F4 MiR‐125b‐protein and protein‐protein interaction network of differentially expressed genes, with particular focus on AHSG (fetuin‐A), FGF‐23, and TNFRSF11B (osteoprotegerin) LTB TNFRSF11B TNF TNFRSF11A BIRC2 LTA FGF23 RELA BIRC3 AHSG GNAS LTBR LAT PMC3589551__F2 Regulation of LTP induction in the hippocampus by NRG1-ErbB4 signaling through suppressing Src enhancement of NMDARs ERBB4 SRC NRG1 PMC2930670__F2 Iron redox cycling in aerobic iron metabolism HP FTH1 TF PMC11535355__F7 Proposed model IRAK1 TRAF6 IL6 TNF PMC5493774__F9 SUMO pathway plays a crucial role in IBD: model representation of importance of SUMOylation in intestinal health and disease NOS2 TSLP TNFAIP3 PMC5681992__F3 Schematic overview of the bile acid signaling pathways to the central nervous system FGFR1 FGFR3 FGF19 NTS FGFR4 FGFR2 PMC5681992__F1 Schematic representation of bile acid synthesis pathways in humans CYP27A1 GCA CYP46A1 CYP8B1 CYP7B1 CYP7A1 PMC3629761__F3 B-cell receptor (BCR) signaling pathway and potential targets BTK CARD11 BCR LYN SYK PMC9459608__F1 Kisspeptins and norepinephrine regulate different G-protein-coupled receptor signaling pathways AMOTL2 EGFR SRC LATS1 MTOR LATS2 ADRBK1 PMC5578700__F1 Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage’s Appetite for Apoptotic Cells MFGE8 EPOR EPO MERTK CD36 PMC6158478__F2 Biochemical pathways of lysophosphatidic acid synthesis and degradation PLD2 LPAR2 LPA PMC8008022__F3 Apoptosis is triggered through two major pathways referred to as the intrinsic and extrinsic pathways CASP3 RIPK1 TLR4 TRADD BIK ADAM10 PANX1 HTRA2 FADD TLR3 PMC5703744__F1 Two major pathways in the cellular folate cycle HEL-S-61p MTR SHMT1 DHFR MTRR ADA HEL-S-70p PMC7853880__F1 Canonical Wnt/beta‐catenin signaling pathway APC GSK3B MYC LRP5 LRP6 JUN PMC4449453__F1 Beyond Adjuvants: Immunomodulation strategies to enhance T cell immunity APC PMC7658481__F6 Pioglitazone effects on TLR and interferon (IFN) pathway TBK1 STAT2 IRF7 IRF9 TRAF6 IRF3 IFNAR2 MYD88 IFNAR1 USP18 STAT1 ISG15 TLR4 PIAS1 MAL PMC5610679__F1 Molecular events occurring in Alzheimer’s Disease (AD) following locus coeruleus (LC) norepinephrine (NE) loss and autophagy impairment FER APP MTOR PMC4777469__F1 Genes and miRNAs involved in the regulation of the intrinsic and extrinsic apoptosis pathway FADD BAX PMC6533856__F1 Leptin metabolism pathway POMC SOCS3 AgRP STAT3 PMC3062410__F2 Networks most highly represented by transcripts differentially associated with HuR after IR treatment EGF FLNA EGFR RALB TNF UBB PS1TP5BP1 NF1 MAX FCER2 ADA ITPKA ECSIT TRAF2 JUN PMC2869512__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis COX2 IL18 VCAM1 CRP TF PMC7354440__F8 PEDV nsp15 antagonizes host antiviral response by degradating the RNA levels of TBK1 and IRF3 TBK1 RIGI IRF3 MAVS PMC6674748__F2 Signaling cascades in axon specification TIAM1 NUMB MAP1B HEL-S-28 APC GSK3B CDC42 PMC3489757__F1 New insights on the role of CD8+CD57+ T-cells in cancer IL2 KLRG1 TGFB1 PMC9504568__F10 1,25-Dihydroxyvitamin D3 Negatively Regulates the Inflammatory Response to Porcine Epidemic Diarrhea Virus Infection by Inhibiting NFKB and JAK/STAT Signaling Pathway in IPEC-J2 Porcine Epithelial Cells STAT1 SOCS3 NR1i1 STAT3 PMC9386495__F9 Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability LIPA IPP PMC8010076__F2 Clustering and pathway analyses of proteins quantified in EAE and CPZ CLTA FLNA ARHGEF3 HEL-S-99n HMOX1 SERPINA3 HEL57 HEL-S-78p HEL-S-44 SERPINA1 APOE ALDH9A1 EPHX1 UBN1 PTBP1 GFAP TCEAL6 RPL18 CP RBP1 BAD UBE2L3 SLC7A11 ASPH HADHB GPX1 HEL-S-128m ISG15 HEL-S-108 DNAJB6 hEMMPRIN PSMB8 SEC61A1 CLIC1 ANXA1 SCG5 CBX3 NFE2L2 S100A9 HEL-S-21 HEL-S-130P DYRK1A ITGAM PSAT1 AHSG TPD52 PPIB PPARG STAT3 PMC5995216__F2 Comparison of the LC3-conjugation pathway during canonical autophagy and Plasmodium-associated autophagy-related (PAAR) response ULK1 ATG12 ATG3 ATG101 ATG10 DKFZp686F0183 NBR1 PMC5742324__F1 Glucose and glutamine catabolism provide tumor cells with biosynthetic precursors MPC1 HEL-S-133P HLA-C HEL-S-281 GLS PMC2277498__F3 Pharmokinetic Limitations of Antioxidant Treatment for COPD BAD TRADD RELA APP TNF TRAF2 FADD PMC8515183__F2 Interactions Between Pathogenic Burkholderia and the Complement System: A Review of Potential Immune Evasion Mechanisms HEL-S-62p C4B_2 PLG VTN C6 C4A CP PMC4589488__F3 Schematic view of bench-to-bedside aspects of colorectal cancer epigenetics SLC5A8 ID4 IRF8 TIMP3 HLTF SFRP1 ITGA4 HEL113 CDKN2A BMP4 PMC5059177__F1 Pterin and monoamine metabolism TH DHFR PAH PMC7808935__F2 Counteracting CAR T cell dysfunction ATM KLRG1 ATR PMC9994446__F3 Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin DAO SKP1 PMC4682887__F1 Vaccines against Gonorrhea: Current status and Future Challenges TH GC IL1B PMC3642145__F2 FIP1L1/PDGFRA+ eosinophil signaling.FIP1L1/PDGFRA+ primary eosinophils express upregulated IL-5 receptor (IL-5RA) and JAK2/STAT5 pathway may be involved in FIP1L1/PDGFRA induced disease development(; ; ) IL5RA CCR3 PMC6827038__F5 Effect of Ad-Cyp8b1 on liver and intestine gene expression and mTORC1 signaling in HFD-fed mice FGF21 CYP8B1 FGF19 FGFR4 PMC9181511__F2 Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity CCL8 CXCL10 CXCL9 IL2 CCL7 CCL5 CCL4 CCL2 HEL-S-104 IL1B IFNG CCL3 PMC8000248__F4 Non-coding RNAs regulating Notch Signaling ADAM17 PMC2606015__F9 Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells BTK VAV3 BCR RASGRP3 BASH GRB2 SRC ARHA SYK RAC1 PMC7995014__F1 Schematic illustration depicting the association of overnutrition/obesity/excess amino acids to angiotensin‐converting enzyme (ACE2) receptors leading to the hyperactivation of mammalian target of rapamycin (mTOR) MTOR ACE2 PMC3180573__F1 Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke MAF KEAP1 SQSTM1 PMC11921618__F9 Schematic model illustrating the mechanism of TMEM176B inhibiting OC progression CCND1 TMEM176B PMC11701242__F10 MTORC1 pathway by condensate TSC2 DYRK3 MTOR DEPTOR MLST8 PMC5885411__F3 Pathway analysis illustrating differential gene expression and association between gene nodes CKAP5 KNTC2 CCNB1 CENPF NEK2 CENPE LMNA AURKA PMC8327843__F2 Regulatory T cell infiltration in tumors: implications for innovative immune precision therapies CXCR3 CCR5 CCR10 CCR4 CCL17 CCL5 CCL28 CCR8 CCL22 CCL1 PMC4938192__F1 Steroid metabolism pathway AKR1C1 CYP7B1 AKR1C2 PMC12065540__F4 Upregulation and downregulation of active factors, mRNA, and signaling pathways during the ulcer healing process GPX4 TIMP1 PKNOX1 DMBT1 PTEN SIRT1 BAX PMC12065540__F1 Pathogenesis of Diabetic Ulcers TNF MTOR PMC8771101__F1 Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage IFIT2 C9 TLR4 ATM HEL-S-2 CXCL10 CD163 opn TMEM119 LPL IER2 ARG1 PMC5676684__F6 Network of miR-93 and miR-21 with putative target genes of important signaling pathways from KEGG enrichment analysis PIK3R1 CTBP2 SOCS3 ATF2 PHKA2 SMAD4 TFDP1 MAP2K6 CRKL CACNA1C PRKCA NF1 BMPR2 SP1 RAPGEF2 NTRK2 SPDY1 BMP8B ROCK2 APC MAP3K5 FBXW11 CRK YWHAQ RPS6KA1 STK4 PPP2CA MEF2C AKT3 PRICKLE2 TBL1XR1 BAD NFATC4 TBL1X EGFR PPM1B INSR PDGFA PTPN11 SFRP1 ZFYVE16 THBS1 VANGL1 RBL1 SH2B3 TAOK3 ARHA GYS1 RRAS2 SMURF1 NFATC3 GNG12 EP300 PTPRE SOS1 HEL-S-93 INHBA PMC7503332__F2 Schematic signaling pathway of TLR7 and 9 TLR7 TLR9 IRF7 IRAK1 IRAK4 MYD88 PMC11853781__F3 Luteolin multi-pathway treatment of IBD IL10 KEAP1 STAT3 PMC11853781__F4 Multi-pathway mechanisms of luteolin in inhibiting colorectal cancer NLRP3 KEAP1 EGFR PMC4174300__F4 Innate immunity to dengue virus infection and subversion of antiviral responses STAT2 IRF9 TYK2 UBR4 PMC4174300__F3 Innate immunity to dengue virus infection and subversion of antiviral responses TRAF3 TRAF6 IRF3 TLR3 MAVS PMC3510027__F3 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease PIN1 PLK1 PIK3CA RRAS BCL2 MSLN RAF1 PPP2R1B FNTA PPP2R5D PMC3510027__F2 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease BACE1 ADAM9 NR3C1 RAB20 NR3C2 IL18BP PPP2R1B DIABLO APTX CASP3 MED14 NR2F6 HTT APP GRIN2B LHCGR MKI67 LTBR FABP1 PMC3594740__F1 TLR signaling TLR4 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TIRAP TAB3 MAL PMC8660693__F1 Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response CGAS IRF3 TNF PMC7023858__F3 IGFBP-3 was a predicted target of SAN by bioinformatics analysis LAT PMC5422801__F6 Hippo–YAP pathway mediates physiological resistance to gemcitabine CDA AMOTL2 LATS1 LATS2 PMC9317325__F3 Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses? TBK1 IRF7 MXRA8 IRF3 MYD88 TLR3 CD81 RNASEL ISG15 TLR7 CXCR4 MSC TYK2 JAK1 MAVS PMC4040611__F5 An MAPK network downstream of SDF-1/CXCR4 signaling in breast CSCs RPS6KA1 MAP3K11 CXCR4 MAPKAPK5 PAK4 MAP2K2 PTPN13 SOS1 HEL-S-31 PMC8393567__F2 GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease MAP1B WNT7A GSK3B PMC2724989__F1 Macrophage activation by endogenous danger signals RNASEL TBK1 TANK TRAF3 TRAF6 TRAF2 FADD PMC9103623__F1 Prolonged Mechanical Ventilation: Outcomes and Management TLR4 MTOR FOXO1 PMC2910166__F7 drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans EIF4H EIF4E RAB10 PMC8889574__F1 Impact of High Dose Glucocorticoids on Bone Health and Fracture Risk in Systemic Vasculitides MPO RUNX2 IL6 CTLA4 DKK1 PMC11842380__F12 Signaling pathways that the exosome may regulate CD80 PMC4572253__F1 Homocysteine metabolism HEL-S-61p PMC7813969__F1 Sex bias of females in survival from cancer and infections. Is X the answer? EZH2 IFNG PMC3843359__F2 MAPK signaling pathway is upregulated in OSI-906 resistant CRC lines TSC2 TSC1 PDK2 GRB2 INS EIF4E MTOR RHEB INSR PMC11813976__F2 Molecular mechanisms of STAT3 signaling pathway in CRC NLK EGF SRC PTPN9 TNF MTOR CSF1 STAT3 PMC4472073__F2 Mechanism of castrate-resistant prostate cancer.Notes: 1) Androgens bind and activate the AR despite the castration of testes-derived androgens RAN PMC9454891__F9 Apigetrin Promotes TNFAlpha-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NFKB Pathway in Hep3B Liver Cancer Cells RIPK1 RIPK3 MLKL BAX PMC7243914__F5 Immune signaling responses occurring in chickens infected with Salmonella CARD9 TLR4 NOD1 MAP2K4 TRAF6 MAP2K3 FZD1 MAP3K7IP1 TIRAP PMC7243914__F4 Immune signaling pathways in bovine monocytes STAT1 TLR9 IRAK1 SHE TRAF6 TYK2 IRAK4 MYD88 IFNG PMC7316088__F3 Hyperactivation of the ATR/CHK1/WEE1 pathway leads to acquired resistance to PARP inhibitors CLSPN WEE1 ATRIP CDC2 ATR PMC7316088__F2 ATR/CHK1/WEE1 pathway compensates for the replicative stress induced by gemcitabine WEE2 CLSPN WEE1 TOPBP1 ATRIP CDC2 ATR PMC5393594__F4 Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells HEL-S-278 ZPBP SPINK2 STAG3 ODF1 EFHC1 PMC11901387__F1 Effect of the microbiota on drug resistance in HCC NLRP3 TLR4 AHR FOXO3A EGFR JAK1 MTOR STAT3 PMC5214938__F1 Cross-regulation between interleukin-1 (IL-1) and type-1 interferon (IFN) inflammatory pathways as exemplified during Mtb infection TBK1 NLRP3 CH25H CGAS IL16 PTGS2 IL1R2 IRF3 IL1R1 IFNAR1 AIM2 PMC5835759__F1 Interactions among Protein Kinase C Alpha (PRKCA), NOS3, and BDKRB2 gene products within the ACE inhibitor pathway may affect the antihypertensive response to enalapril TIMP1 MMP2 AGTR1 BDKRB2 PMC8226943__F2 Redox and Anti-Inflammatory Properties from Hop Components in Beer-Related to Neuroprotection STAT1 NLRP3 COX2 COX1 KEAP1 CD80 NQO1 PMC9201217__F1 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review HMGB1 MYD88 TNF PMC2990976__F2 TNFA signaling pathways to NFKB activation TRADD MAP3K7IP1 TRAF2 PMC9028769__F6 Human Papillomavirus 16 E6 Suppresses Transporter Associated with Antigen-Processing Complex in Human Tongue Keratinocyte Cells by Activating Lymphotoxin Pathway TAP2 LTBR TF PMC9201217__F2 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review HMGB1 TLR5 TLR4 TLR9 CD40 CD80 MYD88 PMC3942836__F1 Schematic review CXCR4 SHH SMO PMC5858164__F7 Working model of endothelial specific elevated miRNA302-367 attenuating embryonic hindbrain developmental angiogenesis by targeting CDC42 and CCND1 multiple pathways PAK1 GRB2 CCND1 CDK4 CDK6 CDC42 PMC8085478__F1 Sclerotic chronic GVHD: you may WANT to block WNT APC LRP6 PMC7812258__F2 Mechanisms through which TLRs orchestrate pro‐tumour responses IFNE BCL2 PMC7812258__F1 Non‐canonical functions of TLRs TLR8 TLR7 TLR4 TLR9 DKFZp686F0183 PMC9265395__F3 Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator? MYC PTEN KDM5A CDK6 PMC2637184__F1 New central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9 ChAT AJUBA ARHA HCTP4 CRKL FYN ECT2 ERBB2 ZYX CXCR4 LCK LYN CXCL12 TGFA SMAD1 ITCH PMC3660716__F1 Intracellular signaling pathways recruited by leptin SOCS3 GRB2 MTOR STAT3 PMC11165723__F3 Journey of a generation: advances and promises in the study of primordial germ cell migration KIT KIF13B CXCR4 SRC ARHA ROR2 RAC1 LPP CXCL12 PMC11650354__F2 Inhibition of the non-canonical Wnt signaling pathway by WIF1 ARHA RAC1 DKK2 WIF1 PMC8678483__F8 Different Molecular Weight Polysaccharides From Dendrobium officinale Kimura & Migo on Human Colorectal Cancer and Transcriptome Analysis of Differentially Expressed Genes HTRA2 FADD BAX PMC11650354__F1 Inhibition of the Wnt/Beta-catenin signaling pathway by WIF1 MMP7 DKK1 WIF1 PMC11650354__F4 DKK3-related signaling pathways in Wnt/Beta-catenin and non-canonical Wnt signaling DKK3 MYC CCND1 AXIN2 PMC11650354__F3 Inhibition of the PI3K/Akt, NFKB, and TGFB signaling pathways by WIF1 MMP2 SMAD2 MMP9 MTOR WIF1 PMC11650354__F5 DKK3’s inhibition of the PI3K/Akt signaling pathway DKK3 RHO PTEN MTOR PMC5983834__F4 PI3K-AKT signaling pathway BAD MYC PTEN RAC1 EIF4E MTOR RHEB RXRA TSC2 BCR MDM2 GRB2 CCND1 SYK EIF4B RBL2 CD19 PMC7198545__F8 TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination TBK1 TRAF3 IRF3 TRAF3IP3 MAVS PMC2383925__F9 MiRNA model for the molecular pathogenesis of recurrent ovarian cancer EGF BRAF USF2 MMP9 BCL2 FGFR2 PMC8610166__F2 Targeting myeloid-derived suppressor cells for cancer therapy CCR2 SEMA4D IL8RB CCL2 ARG1 HDC PMC8590100__F3 Innate immune remodeling by short‐term intensive fasting TBK1 TANK BAD ATG3 TRAF6 ULK2 MTOR SNAP29 DKFZp686F0183 VMP1 UVRAG HMGB1 CTSL ATG12 ATG101 ATG10 DEPTOR HEL-S-130P RHEB MLST8 HEL-S-162eP TSC2 KIAA0226 WDR41 RAF1 STX17 PMC7680678__F1 Therapeutic strategies have been developed to target various steps in the PI3K/AKT/mTOR pathway, thereby blocking cell proliferation, growth and survival EGFR PTEN MTOR PMC10216727__F3 Proposed mechanism of vagus-mediated liver regeneration FOXM1 IL6 STAT3 PMC6003401__F6 Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming TLR4 TRAF3 TRAF6 MYD88 TLR3 TIRAP PMC10216727__F2 Role and function of FOXM1 in pulmonary fibrosis PLK1 MMP2 ACTA2 FGF2 CCNB1 CCND1 TNF STAT3 PMC2768836__F1 Role of clathrin adaptor proteins in melanosome biogenesis EEA1 KIF13A TF PMC7460646__F2 Inflammation contributes to leptin resistance in the brain at the hypothalamic arcuate nucleus, and as a result, alters food intake and energy expenditure leading to obesity REL MAP3K7IP1 STAT3 PMC12112539__F1 IL-23 production and signaling pathway in the context of inflammatory bowel disease pathogenesis TLR4 STAT4 TRAF6 IL1R1 TYK2 IRAK4 MYD88 IL23R JUN REG3G TIRAP STAT3 PMC9294450__F3 Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells PC ARHA PLCB1 PMC10216727__F6 EGFR/mTOR signaling pathways that regulate FOXM1 are involved in Beta-cell proliferation FOXM1 EGFR MTOR PMC3288293__F1 Molecular mechanism of senescence IL6 SIRT1 SIRT3 PMC12112539__F2 IL-23/IL-23R axis orchestrates innate and adaptive immune responses in the inflamed gut mucosa APC STAT4 TYK2 IL23R PMC4174300__F2 Innate immunity to dengue virus infection and subversion of antiviral responses TRAF3 TRAF6 IRF3 TLR3 MAVS PMC4449286__F5 Excess of rare, inherited truncating mutations in autism GIGYF1 GRB10 TNRC6B ZNF598 RBM12 GIGYF2 PMC2697172__F8 Sub-network associated with the Wnt signaling pathway MYB NUMB SET TTK RHO PSD TAF12 PC TBP SUFU CIC SF1 SPEN SMO SIN3A ESD SHF TAF4 PMC9386258__F1 Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism MMP3 COX2 AIP AHR CYP1B1 VCAM1 CYP1A1 IL6 IL1B PMC8236819__F2 Pathophysiologic Role of Neurotransmitters in Digestive Diseases NLRP3 MMP2 MMP9 EGFR ADRB2 DRD2 PMC8608597__F9 Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/Beta-catenin pathway EZH2 NR2A2 PMC5896787__F2 Emerging concepts for immune checkpoint blockade-based combination therapies PC CPT1A LCK ZAP70 PMC8101994__F8 Proposed role of PD-L1 on contraction of activated effector T cells APC CD80 MTOR PMC4854959__F1 Androgen signal pathways SHBG SRC SRY PMC6343712__F6 miR-300 mediates the SP1/MMP9 pathway in BCa MMP9 SP1 PMC6678716__F2 CSCs-activated signaling pathways: Schematic representation of the signaling pathway responsible for induction and maintenance of CSC state SUFU APC TGFBR1 LRP5 LRP6 SMO LATS1 IL6 LATS2 STAT3 PMC2837360__F1 Canonical Wnt/Beta-catenin pathway (modified after ()) RSPO1 APC GSK3B DKK1 PMC6784892__F4 Two intracellular and cell type-specific bacterial symbionts HEL-S-11 EYS PMC3637970__F1 Transforming growth factorB (TGFB) signaling pathway SMAD2 SMAD6 SMAD4 ID1 TF PMC9266365__F8 Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway PINK1 ATM MTOR PMC7690210__F1 Activation pathways of the complement system HEL-S-62p C9 MASP1 C6 MASP2 C4A PMC7264474__F1 Ceramide and Sphingosine 1-Phosphate in Liver Diseases opn SPP2 CERS3 LASS1 CERS5 SPHK1 SPHK2 CERS2 CERS6 HEL-S-5 PMC5428476__F10 Model depicting the involvement of autophagy-lysosomal system in apigenin-induced degradation of Beta-catenin during Wnt signaling GSK3B LRP5 LRP6 MTOR PMC10986035__F5 Pattern diagram for the role of NCAPD3 in NSCLC cell proliferation and apoptosis IGF1 CDK4 NCAPD3 BAX PMC11602425__F3 Metabolic reprogramming drives MASLD progression PNPLA3 NLRP3 CXCL16 MTOR CXCL11 TERT STAT3 PMC11602425__F2 Metabolic reprogramming drives HCC progression TIGAR SHD MYC MTOR TXN IKZF1 SIRT4 PAX5 F2 FH HEL-S-51e HEL-S-133P HK2 GLS PMC11602425__F1 Metabolic reprogramming of tumor cells HEL-S-133P HK2 PMC6747339__F1 Schematic representation of ERK1,2 signalling regulation of channels and transporters along the nephron DCT PTH RAF1 PMC3882431__F6 Schematic representation of the proposed pathway by which deficiency of FXR activates the STAT3 signaling pathway in the liver IL16 SOCS3 STAT3 PMC4254673__F8 Proposed model for autophagy and metastasis mediated by mTOR signaling BAD PPY PTEN MTOR BAX PMC7662528__F6 RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s Disease TLR4 FADD RGS10 PMC3940357__F1 Frizzled homolog proteins, microRNAs and Wnt Signaling in Cancer NLK APC LRP5 LRP6 RYK ROR2 RHO WIF1 PMC11120667__F12 Proposed model of the mechanisms of action of female M CASP3 ATF4 EGFR CASP9 CASP8 FADD TRPV1 BAX PMC11120667__F11 Proposed model of the mechanisms of action of male M CASP3 ATF4 EGFR CASP9 CASP8 FADD TRPV1 BAX PMC12052780__F5 EVs in macrophage polarization within the ovarian tumor microenvironment KAT2B SOCS3 ADAMTS6 HOXA10 KLF6 SIRT1 GATA3 STAT3 CD24 PMC12052780__F4 Figure illustrates how various molecular factors drive TAM polarization and chemoresistance in the OC microenvironment ST3GAL3 POSTN CPNE1 FPR2 ARHA IGF2BP2 KLF6 ADM GATA3 FGF9 PMC3928842__F1 TLRs signaling pathway TLR5 TLR7 TLR4 TLR9 TRAF6 MYD88 TLR1 TLR3 AK1 TIRAP PMC3660182__F1 Glia-mediated detrimental and beneficial inflammatory pathways in PD MPO FZD1 PMC12052780__F1 Wnt and PI3K/AKT pathways involved in macrophage polarization and metastatic progression in the tumor microenvironment of ovarian cancer STAT1 CD163 PTEN ARG1 CEACAM1 CCL3 PMC10484658__F2 Schematic diagram of ERS in renal resident cells in LN VCAM1 ATF4 XBP1 PMC3660182__F4 Crosstalk between inflammatory and Wnt/Beta-catenin signaling pathways in MPTP-induced SVZ plasticity EGF WNT1 GSK3B PMC9299865__F1 Key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions NAPRT NAMPT NRK PMC4176007__F3 IL-6 synthesis and regulation of IL-6 mRNA stability by Arid5a TLR4 MYD88 ARID5A PMC7564205__F5 NRP1-ABCB8 pathway: Schematic representation of the NRP1-ABCB8 pathway in regulating iron homeostasis, iron-dependent oxidative stress, mitochondrial function and cellular senescence VCAM1 NRP1 FES ABCB8 PMC7729316__F1 Therapeutic approaches targeting tumor angiogenesis DLL4 TMEM100 ENG ID1 PMC5769625__F2 Layers of gene expression control in primed human PSCs PRDM14 SOX2 IGF1 SMAD2 APC CTCF FGF2 GRB2 BMP4 PMC5583567__F3 Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis HRAS MTOR DEPTOR SHC1 PMC8645368__F2 Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation IDO1 CCL2 CXCL12 PMC1559676__F1 The unfolded protein response ELF2 ATF4 XBP1 PMC3164770__F5 FLCN pathway TSC2 FLCN BAD TSC1 PIR FNIP2 FNIP1 PTEN PMC9463442__F7 Regulation and role of RNAPII-generated nascent RNA to guide DNA end resection and DSB repair by HR DROSHA RAD52 MRE11A BRCA1 PMC9294638__F2 Emerging Role of Non-Coding RNAs in Senescence APC LRP5 CCND1 LRP6 PMC11941683__F1 Summary of healing stages following a bone fracture RUNX2 APC MSC SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC6823706__F3 Molecular mechanism of inflammatory adipokines involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance PC MTOR IL1B FOXO1 PMC9294638__F4 Emerging Role of Non-Coding RNAs in Senescence GSK3B MDM2 PTEN CAB39 MTOR PMC8176847__F2 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications CASP3 FADD BAX PMC8176847__F1 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications CASP3 MDM2 CASP9 HTRA2 BAX PMC6823706__F2 Molecular mechanism of Fetuin-A involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance CD14 TLR4 MYD88 PMC11847854__F3 Saikosaponin A-target-pathway network IGF1R PLK1 CYP1B1 PTGS2 FGF2 EGFR GSK3B VEGFA BCL2L1 RAC1 HIF1A FLT1 KDR MMP2 CDK2 PTPN1 PTPN11 IL2 BCL2 JUN PMC8487719__F1 Hedgehog signaling pathway SUFU PTCH1 GLI3 SMO DYRK1B PMC3493591__F5 Constitutive ß-Catenin Signaling by the Viral Chemokine Receptor US28 APC GSK3B CCND1 ARHA PMC3712869__F4 Smooth Muscle Differentiation and Patterning in the Urinary Bladder FOXL1 SHH SMO FOXI1 BMP4 FOXF1 PMC3880284__F4 Human Mammospheres Secrete Hormone-Regulated Active Extracellular Vesicles MFGE8 CD133 BAK1 HSP90AB1 ALB HEL110 IPP HSD17B10 F8A3 HEL-S-162eP ANXA2 ERMN MAEA ESPN PMC6980436__F1 Heme metabolism and the microglial toll‐like receptor 4 (TLR4) signaling pathway following SAH: In the subarachnoid space, free heme is metabolized by heme oxygenase (HO)‐1, releasing iron (Fe2+), biliverdin, and carbon monoxide (CO) HMGB1 TLR4 TLR9 MYD88 PMC5355173__F2 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells TSC2 TSC1 GRB2 CCND1 PTEN AXIN2 MTOR DEPTOR IRS1 RHEB MLST8 PMC5355173__F3 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells CDK2 APC GLI3 LRP6 PTEN BAX PMC11693731__F7 Diagram of catalpol enhance Shh signaling pathway to promote neurogenesis and synaptogenesis by regulating mitochondria SHH SMO PMC5355173__F8 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells WNT3 WNT1 LRP6 CDH2 AXIN2 SIRT1 CDK6 PMC14940__F10 A signaling pathway of c-Met for cell scattering HGF RHO VAV2 PMC4851234__F2 Negative regulators of necroptosis RIPK1 TRADD RIPK3 TNF PPM1B TRAF2 MLKL PMC3975104__F2 A simplified model of some of the signaling pathways leading to LTD of the pf-PC synapse IGF1R PC IGF1 GC PMC7793877__F5 Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema CSNK1D MAP2 BAG4 CRY2 SMAD2 HEL-S-101 SMAD4 FGFR4 RB1 HIF1A CLU THRSP AHR LPL CDK4 JUNB PER2 PER1 CRY1 FOS GULP1 MAPK10 ATF3 UHRF2 TNF PPP2R1B AURKA DDIT3 BEX1 CDK2 RELA LCK hCG_2014051 JUND REL NPAS2 STK32C TGFB1 PCNA PMC4196646__F1 Signalling pathways connected to autophagy DISC1 GSK3B MTOR PMC5796046__F3 PB1-F2 virulence TBK1 NLRP3 CALCOCO2 IRF7 TRAF3 TRAF6 IRF3 TRAF2 IL1B MAVS BAX PMC5265918__F9 Atorvastatin inhibits insulin synthesis by inhibiting the Ras complex (Ras/Raf/extracellular signal-regulated kinase/CREB) in INS-1 cells PDK2 GRB2 PMC7374820__F5 Ingenuity Pathway Analysis (IPA) of network of eight DE genes PIGF MOS TINAGL1 UGDH ACOT11 STC1 WNT9A NPEPPS FOXC2 KRT18 FAT1 MMP3 PMM1 DUT PRKAG2 DYRK2 PPIC TSPYL2 CP APH1B TAF4 PMC5511151__F7 Mechanisms underlying crosstalk between Wnt/Beta-catenin signaling and insulin signaling via Irs1 during hepatocarcinogenesis IRS1 PMC11278952__F3 Alterations of bile acids involved in the synthesis pathway in HD CYP27A1 GCA CYP46A1 CYP8B1 CYP7B1 CYP7A1 PMC5967641__F1 NAD+ biosynthesis, consumption and salvage pathways NAMPT NMNAT1 NMNAT2 NNMT NMNAT3 NRK PMC5471278__F5 Regulatory network model of DNA replication coupled with nicotinamide MCM3 MCM2 DBF4 SIRT1 PMC5471278__F3 Interaction network model RBMS1 PRIM1 PAH DTL CDK6 PRKCA POLE POLA2 TOPBP1 SRC RAD51 USP22 PARL TRIO OPA1 ARHGEF4 CHTF18 PLAUR RIF1 APC HEL-S-310 DIABLO BRCA1 CLSPN MCM6 RASSF1 BRCA2 HEL-S-269 MBTPS2 TNFRSF1A RBBP7 DIDO1 BCL2 OS9 FOXM1 BLM ERF DNAJC10 TOP2A DBF4 WFS1 CLU TXNDC12 NPAT TMX4 ECT2 RRM1 PAWR RRM2 NDUFA13 CCNB1 EIF4B RPA1 NFE2L2 NDUFS3 CHEK1 HYOU1 RAD18 TRIP12 ERN1 TYMS LTBR PMC9173662__F1 Complement pathways HEL-S-62p C4B_2 CD46 CPN1 C4A CLU CPB2 CFH CPN2 VTN CRP CD55 C1S CFHR1 PMC10688769__F4 miRNA alterations affect cartilage synthesis ADAMTS5 MSC COL2A1 SOX9 PMC8932121__F2 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD NLRP3 TRAF6 MYD88 CSA2 PMC6073096__F4 Simplified DNA repair pathway diagram ATM BRCA2 SSB RAD51 ATR BRCA1 PMC10688769__F2 Cell-produced SASP affects OA ADAMTS4 ADAMTS5 MSC COL2A1 DNMT3B SOX9 PMC7263368__F1 Representation of Hippo-Yap core kinase signaling cascade PITX2 STK4 LATS1 LATS2 PMC6754407__F7 Model of SHH induced increase of HELLS HELLS YAP1 SHH PMC7263368__F5 Representation of Yap regulation by P2y2 signaling LATS1 LATS2 PMC10995332__F5 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma SMYD3 RCL1 ZEB2 GATA6 HEL113 CDH2 TF PMC10995332__F4 MiRNAs affect the occurrence and development of EMT in liver cancer cells by activating the TGFB signaling pathway and cross-talking multiple signaling pathways including PI3 K and MAPK SMAD2 MMP9 SMAD6 SMAD4 DNMT3B SMAD9 MMP2 FAP HEL113 CDH2 SP1 SMAD1 DKFZp781O1323 PMC6540604__F1 The deregulated metabolic pathways in AML CS SPHK1 MCL1 HEL-S-104 ASS1 HEL-S-133P TET2 BAX CD36 PMC8932121__F4 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD TBK1 CGAS IRF3 C9orf72 TNF OPTN PMC6888166__F1 Signal transduction of the unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC5340842__F1 P. infestans infection cycle and the many roles effectors play in modulating plant cellular processes MAP3K1 MAP2K1 BAK1 MAP3K2 MAP2K2 MAP2K3 TF PMC6804972__F3 Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance FOXM1 NPPB MYL3 THBS4 RCAN1 CTGF BCL6 NR1i1 NPR3 HEY2 KCNJ2 ATP2A2 CASQ2 KCNJ5 ACE2 ALDH2 PMC10995332__F3 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma HEL-S-28 PTEN CXCL12 CDH2 HIF1A MTOR PMC10995332__F2 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma NLK LEF1 WNT3A APC WNT1 MYC CD44 FZD7 RAC1 NKD1 PMC6901970__F1 Regulation of Tfr cell differentiation and function IL10 PTEN FOXO1 ICOS STAT3 FOXP3 PMC1728094__F1 The receptor for IL-6 consists of the ligand binding component (IL-6R) and the signal-transducing gp130 VCAM1 STAT3 PMC11203016__F10 Illustration of the Toll-like receptor signaling and apoptosis pathways in M CD14 STAC ATM POR CAD CP TIRAP PMC7225374__F11 Core apoptotic pathway and its regulation by miRNAs in THP-1 cells exposed to the lower dose of CdS QDs BAD BIK PTEN BMF FADD SIRT1 FAF1 CDC42 HRK BAX PMC7940541__F7 Schematic model: the mechanisms through which huaier extract inhibits the growth of prostate cancer USP14 SMYD3 KLK3 TMPRSS2 PMC8542577__F4 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease NOP16 NR5A2 NCOR1 FOSL1 THBD COL3A1 RUNX1T1 TEF PROX1 CEBPB PROK2 PMC8548714__F1 Current Application and Future Prospects of Astragalus Polysaccharide Combined With Cancer Immunotherapy: A Review STAT1 ALK MSC CCL22 ROS1 TGFBI IFNG STAT3 PMC8542577__F3 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease F10 TFPI PLG THBD F8 F9 KLKB1 A2M F3 VWF F11 SERPINA1 SERPINF2 BOK PMC8546664__AF1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy TBK1 ATM IFNE IRF3 IFNG PMC4906842__F2 Steroid biosynthesis pathway STS CYP11A1 CYP17A1 CYP11B2 PMC11972380__F8 Schematic diagram deciphering the mechanisms by which ROBO1, G3BP2 and eIF3A form hetero-complex to mediate radio-resistance in ESCC cells G3BP2 EIF3A ROBO1 MTOR PMC2996094__F11 Proposed model of GF-mediated regulation of IGFBP-3 EGF EGFR MTOR PMC8005042__F7 Pyrimidine biosynthesis in the pyrimidine metabolism pathway UMPS CAD DHODH PMC11628519__F3 Molecular mechanisms of the JAK-STAT pathway in CRC cell proliferation, apoptosis, migration, and invasion NR1i1 ATM MYC ARHA STAT3 BRD4 PMC8415165__F11 Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway SOCS3 IL1B STAT3 PMC8267717__F2 Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis CD14 TLR4 IRAK1 LBP TRAF6 IRF3 IRAK4 MYD88 PMC8945898__F1 Histamine Intolerance—A Kind of Pseudoallergic Reaction DAO HDC PMC4427128__F1 Coagulation and inflammatory response activation during dengue IL16 TFPI CD40 CCL2 TF PMC4477307__F10 Cooperative disruption of signaling network downstream of mutated KRAS TIAM1 PAK1 BAD RAC1 SOS1 CRK PMC2647860__F7 p53, Cyclin-dependent Kinase and Abnormal Amplification of Centrosomes PLK1 CDC25B PMC9086356__F1 Innate Lymphoid Cells in Cancer Development and Immunotherapy GIG8 AHR CCR6 NFIL3 TOX GATA3 PMC7265313__F9 Final scheme FBF1 SCLT1 DAP SMO CEP164 PMC5817860__F3 Crosstalk between c-Met and EGFR EGF BAD EGFR GRB2 MTOR TGFA PMC10537261__F3 Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis NPY AgRP ARC PMC3421049__F1 Genomic Variation and Neurohormonal Intervention in Heart Failure GNB3 CYP11B2 PMC7987467__F1 Severe SARS-CoV-2 syndrome as a result of hypoxia and HIF-1 signaling pathway activation HEL-S-62p CCL2 TNF PMC7403780__F6 Recombination salvage pathway regulation RAD52 RAD51 PCNA PMC2929667__F6 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation IGF1 PCK1 PPARGC1A IGFBP1 GHR GCK STAT5B IRS1 ONECUT1 FOXO1 IGFALS FOXA2 PMC8946206__F2 Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future EGF EGFR MTOR PMC544835__F1 Reverse Cholesterol Transport APOB LDLR ABCA1 PMC6406579__F3 Current model of Cln3 function in Dictyostelium CLN3 TPP1 HEL-S-130P PMC4403904__F1 Signaling pathway mediates hepatic fibrogenesis: (A) the TGFB1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFB1/NFKB pathway SMAD2 SMAD4 TRAF6 MYD88 PMC3681501__F5 Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway HMGA2 IGF1R IGF2 IGF2BP2 CCND2 PMC5113843__F3 Proposed metabolic role of RubisCO, with genes identified in the PER-1 (blue line) and WS6-1 genomes (purple line) HEL-S-304 RPIA HEL107 RPE HEL-S-162eP PMC7136022__F4 PGE2 signaling pathways COX2 GSK3B SRC PMC6650088__F2 Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference MMP3 PIK3R1 CHIT1 PI3 RGS5 SET RUNX1 PIK3CA PTEN MPL KCNK2 OR10X1 PMC3726373__F5 Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer RRM1 PTEN CDH2 PMC6958506__F4 A summary of miR-205-5p expression regulation and direct targets of miR-205-5p and their biological effects NOTCH2 AMOT YAP1 ERBB2 ERBB3 FGF2 LAMC1 HES1 PMC8637616__F1 Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease PTEN MTOR PMC6164844__F2 Suggested mechanistic pathway of different flavonoids in the activation of non-shivering thermogenesis in BAT and WAT PRDM16 UCP1 CPT1A SIRT1 PMC4595741__F3 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica CIT MAL PMC4595741__F1 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica HP CIT MAL PMC4795655__F4 De Novo Transcriptome Analysis Provides Insights into Immune Related Genes and the RIG-I-Like Receptor Signaling Pathway in the Freshwater Planarian (Dugesia japonica) TBK1 IRF7 TRAF3 TRAF6 RIGI IRF3 TRAF2 PMC9575458__F2 Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview PTEN IRS1 INSR PMC4808588__F4 Multifaceted biology of plasmacytoid dendritic cells PLSCR1 BTK TLR9 IRF7 UNC93B1 PACSIN1 SLC15A4 MYD88 SCARB2 DOCK2 PMC7243120__F1 An autoregulatory loop controls Proline biosynthesis ATF4 EIF2A ALDH18A1 PMC4338588__F1 Hypothetical model illustrating the molecular basis of insulin-induced metabolic stress in patients with poorly controlled T2D in which both blood glucose and FFA levels are persistently elevated DYSF TG CD36 PMC3186011__F1 Cell surface and endosomal recognition of viruses by Toll-like receptors (TLRs) IL1A TLR7 TLR4 TLR9 TRAF3 TRAF6 IRF3 IL6 IL1B TLR3 PMC9594080__F1 Redox potential determines NSPCs fate KEAP1 ATM MTOR PRX PMC1482699__F5 GenMAPP growth hormone (Gh) signaling pathway PTPRT SOCS2 DAO CEBPA SSTR2 CRK STAT5B DUSP19 CEBPB GHRH CALM1 CEBPD GHRL FYN AK3 STAT4 SOCS4 GHR FURIN NMI GHRHR SP1 GRB10 SP3 PMC5454413__F2 Proposed regulatory signaling network for HCV entry EGF BMP6 BMPR2 VLDLR ICAM3 EGFR SMAD6 LDLR BMP7 ARHA HRAS PMC6124548__F6 Somitogenesis and somite patterning FGF2 FGF8 SHH BMP7 BMP4 PMC12112207__F5 Isochlorogenic Acid C Alleviates Allergic Asthma via Interactions Between Its Bioactive Form and the Gut Microbiome ALOX15 ALOX12 ALOX5 CGA PMC4457157__F3 Crosstalk between growth factor and adhesion protein signaling GSK3B SRC PMC3651056__F2 Arachidonic acid metabolic pathways and the role of IL-13 LTA COX1 IL13RA1 LTB PMC3308858__F8 How GSK3B phosphorylation is involved with microtubule destabilization GSK3B CDK5 CRMP1 PMC7207169__F3 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? ERN1 MYC XBP1 PMC7207169__F2 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? ATF4 EIF2A PMC4094593__F9 Diagram of the roles of miR-206 in hepatocellular carcinoma (HCC) HepG2 cells NOTCH3 BAX HES1 PMC8815128__F6 N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NFKB/A20 axis YTHDF2 AGO2 POLI PMC3638721__F7 TRAIL-activated proapoptotic and antiapoptotic pathways CASP3 FADD PMC6735542__F1 SLC3A2 in regulation of autophagy activation and cell radiosensitivity SLC7A5 SLC7A11 SLC3A2 MTOR COCH PMC3745713__F2 Methionine–homocysteine and aromatase pathways and their involvement in 2-ME synthesis MTR VIT MTRR PMC9022112__F1 Nitric Oxide in Plant Senescence HEL60 HEL-S-162eP PMC8286120__F4 Goblet Cells in Intestinal Barrier and Mucosal Immunity IL33 HEL-S-92n IL25 MUC2 PMC8267409__F1 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects KEAP1 GSKIP PSEN1 ABCC1 PTEN SLC3A2 USP22 PIK3R3 SIRT1 MAGEA3 PMC9450509__F9 DDX56 inhibits PRV replication through regulation of IFNB signaling pathway by targeting cGAS TBK1 DDX56 CGAS IRF3 PMC8267409__F3 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects HMGA2 AGO2 ZEB2 DHFR BCL2 SND1 PMC8333094__F9 Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic Beta-oxidation CROT ECHS1 PMC8267409__F2 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects COX2 OGFR RBM38 ATG3 ZEB2 PTEN MTOR USP22 SIRT1 STAT3 PMC4629213__F1 Bile acid synthesis and metabolism CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC8267409__F4 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects EPCAM MDM2 PTEN EZH2 MTOR HEL-S-4 STAT3 PMC3285581__F7 Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium MUC1 MSX1 MSX2 HEL110 PMC5739690__F8 Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway IRF9 TYK2 JAK1 USP18 PMC7432461__F3 Interactions of coronavirus proteins with metabolic pathways ALDH3A2 AASS PRIM2 FPGS PRIM1 CYP51A1 CHPF2 ACSL5 NANS POLR2B POLA1 POLA2 GCS1 IMPDH2 HEL20 HSD17B4 PPT1 ADK ENO3 PIGO NDUFB9 GANAB ENO1 PIGS ALG5 LPIN3 MTMR3 FAHD1 PCYT2 THTPA DHRS9 PLD3 RRM2 ALG8 NDUFA13 DCTPP1 XDH CHPF ATP6V1A ALG11 GNE GPAA1 ATP6V1G1 STT3B ADA SPTLC2 NDUFA10 ACSL3 ACADM PMC11817190__F3 Influence of micronutrients on bone metabolism RUNX2 SOST MSC PTH DKK1 PMC5753398__F1 Hedgehog signaling pathway HHIP DHH IHH GLI3 SHH SMO PMC2613930__F4 Genes that contain the 100 most differentially methylated CpG sites between normal and lung cancer tissue samples (p-value < 0.005) MAGEA1 MOS NCL IGF2 TNF WT1 PENK GALR1 CFTR HOXA11 POMC NPY CD2 SFTPA1 TP73 PTPN6 HTR2A MYOD1 TERT NEFL PMC7662392__F2 Potential mechanisms for KSHV manipulating IL-1 signaling pathway IRAK1 IL36A IRAK2 IL1RL1 IL33 IL36B IL1R1 IRAK4 MYD88 IL18RAP IL18R1 PMC9599057__F3 Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer CDK2 MDM2 CDK4 PTEN CDC2 TNF FADD CDK6 BAX PMC5943638__F1 Metformin as a Tool to Target Aging IGF1 MTOR IRS1 SIRT1 INSR PMC11743488__F1 TGFB pathway signaling in MFS TGFBR1 LTB PMC9319879__F2 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications TIAM1 BAD RASSF1 GIP PMC5648141__F10 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks IRF9 GFAP MCL1 MTOR RYR2 PMC5580487__F2 Pro-apoptotic role of HBV APAF1 FADD BAX PMC9319879__F1 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications TIAM1 GRB2 GIP MTOR PMC10985007__F1 HIFs and NRF2, adaptive response systems to variable oxygen availability VHL RBX1 PMC5580487__F1 Inhibition of apoptosis by hepatitis B Virus (HBV) infection BAD TRADD APAF1 DBH RELB SRC CD40 PTEN REL TRAF2 JUN FADD PMC3510514__F6 Model for the role of Spartan in DNA damage tolerance RAD18 PCNA USP1 PMC8718907__F2 Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology GNE NEU2 NEU4 CMAS SLC35A1 NEU1 NANS NEU3 SLC17A5 NANP PMC4303658__F1 Thymidine metabolism in the cytosol and mitochondrial matrix CDA DHFR TYMS PMC5302999__F2 Progress and perspective of TBX6 gene in congenital vertebral malformations WNT3A TBX6 HES7 MESP2 PMC6733361__F1 The potential molecular pathways representing potential targets for treatment in patients with ACC, based on the results presented in the current review TSC2 TSC1 IGF1R IGF2 CDK4 PTEN CDKN2A IRS1 CDK6 IGF2R PMC3653416__F2 Autophagy in alcohol-induced liver diseases ULK1 MTOR CYP2E1 PMC6651518__F10 Mutual interactions of expression of the genes examined with qPCR and shown in , and HEL70 VEGFA TUBB1 CXCL8 TLN1 IL6 RDX LAMA3 PS1TP5BP1 LAMA1 TIMP1 CAV2 HEL114 PMC9388619__F2 Canonical G1/S pathway WAS RB1 PMC6353800__F1 Schematic overview of major enzymes and metabolites involved in the regulation of gluconeogenesis PC TG PMC2515553__F1 Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective STAT1 CAV3 TES LCK GSK3B MDM2 SRC PTEN JAK1 STAT3 PMC5055986__F7 A probable signaling pathway of folic acid mediated modulation of inflammatory response in microglia cells IL16 SOCS3 SOCS1 PMC7867260__F3 Gluconeogenesis and other rescue pathways for the generation of metabolic intermediates in low-glucose conditions PCK1 FBP1 PCK2 PMC4252877__F4 Embryonic development, organ development, organ morphology, cellular growth and proliferation, cancer, and tumor morphology DGIC AREG IGF2 CD200 STK39 KRT18 RUTBC3 NDUFV3 EMID1 FOXA1 CCND1 NTRK2 MEOX1 PMC6353800__F4 Hepatic gluconeogenesis is modulated by histone deacetylases (HDACs) GCGR HDAC3 HNF4A CRTC2 RORA FOXO1 PMC7867260__F2 Biosynthetic pathways branching from glycolysis in glucose-replete conditions HEL-S-133P HK2 GLS PMC11662784__F5 DEAD-Box Helicases in Colorectal Cancer: DDX27: DDX27 promotes the gene expression of known CSC markers (CD44, CD133, EpCAM, LGR5), stabilizing the self-renewal phenotype of CRC cells and contributing to tumor initiation and development EPCAM SMAD2 CD44 GPR49 DDX27 CDK6 FUT3 DDX46 DDX56 DDX39B WEE1 STUB1 CCND1 PMC11662784__F4 DEAD-Box Helicases in Colorectal Cancer: DDX3: DDX3 enhances the transcription of KRAS by increasing the binding of SP1 to the KRAS promoter, leading to increased KRAS expression and activation of the PI3K/AKT pathway NPM1 FOXM1 CYBRD1 WDR5 RPL35 DVL2 CDC2 DDX5 SP1 DDX10 MTOR DDX27 PMC11662784__F3 DEAD-Box Helicases in Gastric Cancer: DDX5: DDX5 increases the expression of p-mTOR and p-S6K1, promoting the growth of gastric cancer DDX46 CDK2 GSK3B DROSHA PTEN LPP DDX5 MTOR DDX27 DDX24 FOXO1 CCNE1 PMC11662784__F2 DEAD-Box Helicases in Esophageal Cancer: DDX5: DDX5 enhances the expression of CDK2 and Cyclin D1, promoting the G1/S phase transition in esophageal cancer cells DDX46 DDX51 CDK2 PTEN DDX5 MTOR PMC6405391__F1 Energy imbalance leads to obesity IL6 TNF TG PMC3941025__F1 MAVS filaments and activation of the IFN-I pathway IRF7 IRF3 MAVS PMC5510910__F9 Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum NLRP3 SYK IL1B PMC4014927__F2 Summary of statin‐mediated peroxisome proliferator‐activated receptor G (PPARG) activation in macrophages RHO ABCA1 CDC42 PMC12230643__F4 Multi‐omics network of hyperglycemia‐induced vascular calcification GAD2 GOT2 TNIK GAD1 AGTRAP pcap PMC10341911__F3 Syntenic analysis of genes in the Moso bamboo and rice cytokinin pathway families HP PMC5448611__F9 PPI network of new predicted LUAD-related genes PGR TUBB6 TGFBR2 SLIT3 SPN SLIT2 STARD13 JDP2 BMPR2 CSTF2 TIMP3 STX11 TNS3 MKI67 ADAMTSL3 FLI1 PAPSS2 FGF2 ACTN2 ARHGAP24 IL8RB RCC1 FZD4 CENPL THBS2 KLF4 TYMS JUND PRKCH JAM2 CP TCF4 PRICKLE2 CD36 ARAP2 PMC5933117__F6 Model of rRNA biogenesis in rice HEL-S-66p POLI PMC4700483__F5 MYC splicing connections in cancer MAX PTBP1 MYC MDM2 CCND1 PMC4467525__F5 Summary of altered glucose metabolism in MCF10A-ras cells HEL-S-133P HEL-S-68p PMC7183504__F2 Key interactions of BMX and its pathways STAT1 ITK TXK BTK PIM1 PAK1 TEC BMX ARHA PKD1 TNF STAT3 PMC4052589__F1 Possible mechanisms of the opioid receptor–mediated influence of morphine on tumor growth EGF BAD MOS CCND1 SRC ARHA PMC4515825__F9 Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis HEL-S-1a HEL-S-32 MDH2 PMC5039670__F3 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research BAMBI E2F4 NODAL ROCK1 PITX2 SMAD2 SMAD6 SMAD4 SKP1 ARHA RBX1 SMURF1 IFNG FST SMURF2 THBS1 SP1 DKFZp781O1323 PMC9612132__F2 Heparin and Heparin-Based Drug Delivery Systems: Pleiotropic Molecular Effects at Multiple Drug Resistance of Osteosarcoma and Immune Cells ABCC10 ABCC1 NOTCH1 SRC ABCG2 HIF1A ABCB1 IRS1 STAT3 PMC9302595__F2 Extracellular signals activate the intracellular signaling pathway mTOR TSC2 TSC1 GIG8 PTN LGI1 PTPA FGFR2 PMC6000924__F2 Summary of the putative mechanisms of mutations in the LRRK2 ROCO domain MFN1 VPS35 MFN2 OPA1 PMC4923873__F1 Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway SET CAD SCX PMC7598260__F7 Visual representation generated by MetScape (CREGN) application of the Urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine, a common pathway among the three species GPX4 GPX6 ASPA DHPS NAGS GPX7 GPX3 CSTA ACY3 ARG2 ASNS SRM HEL-75 ARG1 SMS ASL PMC4852766__F6 Proposed models that potentially link collagen VI myopathy and circadian genes FOXO3A HIF1A MTOR ATG14 PMC5039670__F4 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research MYC PIGS PTEN MTOR CDK6 RFWD2 TSC2 CASP3 SIAH1 PERP ATM CDK2 MDM2 CASP9 CDK4 ATR CASP8 BAX PMC9302595__F1 ET-1 signaling in OPCs EDNRB EGFR UST GSX1 S100B PMC4538650__F2 Schematic of TRIM21 antiviral mechanism TBK1 UBE2W UBE2V2 HEL-S-71 TRIM21 RIGI IRF3 PMC5713369__F5 Proposed mechanism whereby SM70EE ameliorates learning and memory impairments in mice with an intracerebroventricular injection of amyloidB 1–42 (AB1–42) BACE1 APP BDNF PMC10137601__F7 Working model illustrating the mechanism that underlies the role of RA in regulating LH-induced oocyte meiotic resumption EREG EGR1 ZFP36 NPR2 PDE3A AREG EGFR RBP4 CNP NPPC PMC8120225__F3 MicroRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies SMAD2 SMURF2 SMAD4 DLX5 MAP3K7IP1 SMAD1 DKFZp781O1323 PMC3697968__F5 Model of DAF-2/IGFR pathway regulation by DPY-21 PMC6651415__F5 Possible mode of cell death pathway in Caco-2 cells CD27 BCL2L10 BIK RIPK2 TNF BCL2L2 PMC7462863__F6 Genomic landscape of Mongolian hepatocellular carcinoma AMER1 DKFZp781B1423 ALB MYC PCDH7 CSMD3 CSMD2 DES PTEN RB1 FGFR2 RPTOR CCNE1 AK2 ERBB4 ATM TLE4 SFRP1 KIT PDGFRA PNRC2 APC MLX SPTA1 GTF2IRD2B PCLO TSC2 APOB VPS13A MAX SMC6 PIK3CA FKBP9 MGA PMC7114592__F2 Role of MNK1 in viral mRNA translation GRB2 BPI PMC4843955__F1 Signalling and muscle proteins synthesis (MPS) responses induced by amino acids (AAs) and different contraction intensities EEF2 EIF4E MTOR PMC2474943__F7 Points of action of flavonoids within PI3K/Akt signalling pathway BAD PDK2 MTOR PMC6291580__F1 Genetic determinants of cardiovascular risk in SLE HLA-A IRF8 FAM177A1 STAT4 IFNG PMC2474943__F5 Points of action of flavonoids within p38 pathway MAX ATF2 MAP3K7IP1 PMC2474943__F4 Points of action of flavonoids within JNK pathway ATF2 SMAD4 HSF1 PMC7031694__F2 Ionic versus signaling pathways for cardiotonic steroid effects EGF EGFR SRC PMC3351101__F2 Regulation of cytoplasmic mRNA decay ELF2 PABPC1 ELF3 PABPN1 EIF4E MAGOH EIF4B CTIF PMC9411277__F4 Targeting of the tumor immune microenvironment by metformin IGF1 HEL-S-92n CD80 PMC8109080__F9 Mechanistic schematic diagram showing Compound 3C alleviates atherosclerosis by multiple mechanisms STAT1 TG APOE PMC4399077__F5 Canonical and noncanonical Sap-induced inflammasome activation NLRP3 IFNAR1 IL1B PMC8379419__F2 Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish IGF1 SLC38A9 ARG2 INS ARG1 PMC5925453__F7 Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis EGF HGF YAP1 AREG EGFR ERBB3 VGLL4 LATS1 MTOR CDCP1 LATS2 ERBB2 LYN SRC EPHA2 PXN STAT3 PMC7377265__F7 Proposed Model Illustrating the Role of GABA and GABAB1R in PTGs CASR PTH PMC6525564__F4 Adrenal C19 steroid pathway HSD11B2 CYP11A1 HSD3B2 CYP17A1 STAR PMC4541793__F1 ANTI-TGF-ß THERAPY IN FIBROSIS: RECENT PROGRESS AND IMPLICATIONS FOR SYSTEMIC SCLEROSIS SMAD2 UNK PMC9378677__F8 Schematic view of cell death signaling induced by 5’-ppp-RNA, cytosolic dsRNA, and extracellular dsRNA CASP9 IRF3 CASP8 FADD TLR3 PMC9024684__F2 Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease FYN PTN IL34 PMC5748797__F1 Formation of resveratrol metabolites by various UDP-glucuronosyltransferases (UGTs) and cytosolic sulfotransferases (SULTs) in humans SULT1A1 UGT1A9 SULT1A2 ST1A5 SULT1E1 UGT1A1 PMC6874786__F1 PI3K/AKT/mTOR pathway in AML ATG12 IL6 PTEN DKFZp686F0183 STAT3 BAX PMC7647985__F4 ERK5 regulates the FAK signaling NFKBIA ITGB3 WASF2 VTN FGF2 GRB2 VEGFA DOCK3 RHO RAC1 ITGB1 CRK PMC6592856__F3 Hippo signalling pathway: key components and regulatory mechanisms MOB2 NF2 ARHA PMC7738833__F8 Hypothetical model illustrating that ALKAL1 plays an important role in colorectal cancer migration and invasion via activating SHH signaling pathway MMP3 LIMK1 ALKAL1 ROCK1 SUFU PTCH1 MMP9 SHH SMO PMC3765338__F3 Altered CREB/E2F1 signalling networks in co-treated HMCs FHL1 CREB1 TFRC RB1 MAP2K3 TOP2A HEL-S-104 CTGF BMP4 CEBPD SCD LDLR LEPR JUNB CDC2 ETS2 ACAN CDH2 EN1 FOXE1 HMGB2 ADM IFI16 KAT2B CBX3 PDGFRA FGF2 IGFBP7 RGS2 ID1 ID3 MYBL1 EDN1 E2F7 EGR2 CPT1A ABCA1 CXCL12 PPARG EPHB2 PMC5908807__F2 YAP is at the epicenter of a signaling network MUC1 EGF KIF23 FOXM1 CXCL5 EGFR EZR AHNAK DKK1 SERP1 GPR87 CDK6 ITGA2 RRM2 CCND1 NOTCH2 FOSL1 AREG AJUBA HBEGF CEP55 AURKA EDN2 IGFBP2 MSLN TGFA PMC11680093__F5 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture SMAD2 PGC SMAD4 SMAD1 DKFZp781O1323 BMP4 PMC7831924__F2 Modulations of Hippo signaling in gliomas IKBKE CUL7 AMOTL2 EGFR GSK3B GSC LATS1 MTOR LATS2 NEDD4 PMC9426031__F7 Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche TH SOX21 MSC ELL PMC5908807__F1 Hippo signaling and YAP phosphorylation and translocation MAP4 LATS1 LATS2 PMC4166351__F1 AB production and removal from the brain HEL111 APP PMC7831924__F1 Canonical Hippo signaling pathway in mammals TEAD3 BIRC5 MYC SHH TEAD4 LATS1 AXL LATS2 TEAD2 PMC5908807__F4 YAP signaling is associated with unfavorable prognosis for PDAC MUC1 KIF23 FOXM1 CXCL5 EGFR EZR AHNAK DKK1 SERP1 GPR87 CDK6 ITGA2 RRM2 CCND1 NOTCH2 FOSL1 AREG AJUBA HBEGF CEP55 AURKA EDN2 IGFBP2 MSLN TGFA PMC11680093__F6 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture TSC2 RICTOR BAD TSC1 GSK3B CCND1 PTEN MTOR PMC4956935__F2 Proposed IGF‐interaction with PPAR‐G signalling in CVD epigenetics TSC2 TSC1 MTOR RHEB PMC3882377__F6 Schema of our hypothesis SHH SMO CD36 PMC5895694__F1 Cross talk between CEA, TGFB signaling, and IL6-STAT3 pathway TGFBR1 TGFBR2 SMAD4 STAT3 PMC4546315__F1 The insulin/IGF1R signalling pathway IGF1R GRB2 IRS1 PMC4356074__F3 Canonical and non-canonical Wnt signaling pathways APC GSK3B ARHA PMC4070521__F1 Biosynthetic pathway of n3 and n6 PUFAs highlighting a set of genes known to play key roles in the biosynthesis and metabolism of LC-PUFAs in two parallel and competing pathways FADS2 FADS1 GLA HEL-S-5 PMC6475556__F7 The mechanisms of total triterpenes of the E TLR4 NQO1 BAX PMC4103158__F3 Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns CS TPM1 MYL2 TPM3 MYL1 MYL3 TNNC2 DES DMD MDH2 HEL-S-108 TCAP FH IVD ACO2 TNNT3 MYL4 SDHA SDHB HMGCL ACTN2 DLD TNNI1 DBT MYH6 TNNI2 HEL-S-273 SUCLG1 HEL113 SUCLA2 MYH8 PMC8275185__F8 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant BAK1 BIN2 CPD PMC6599049__F6 Proposed mechanism for antiviral activity of manassantin B toward coxsackievirus B3 TBK1 CGAS IRF3 PMC11989106__F1 MTOR signaling pathway: The mTOR signaling network consists of two branches, each mediated by a specific complex, mTORC1 and mTORC2 TSC2 TSC1 LARP1 PTEN EIF4E DEPTOR RHEB PMC4248024__F1 The NAD pathway model NAPRT NADK NNMT PARG PNP NRK PMC6356085__F6 Network analysis identified RABEP2 as an important protein in inflammatory and signaling pathways implication in the development of inflammation and cancer CHUK SRP14 HEL-S-310 FKBP3 RPL4 UNC13D SRPRB RPL31 SRC RABEP2 GALNT3 PDLIM3 SMS PMC9284958__F1 Comprehensive network map of IL-17A signaling pathway STAT1 LIF RELA PMC9170606__F2 Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review PMVK MVD FDPS MVK PMC10742340__F1 Molecular signaling pathways associated with Mn neurotoxicity CGAS IRF3 PTEN TNF RHEB NLRP3 PINK1 IL18 EIF2A BDNF SIRT1 STAT3 BAX PMC5722193__F2 Acute metabolic effects of AMPK activation TSC2 PFKFB2 MTOR CD36 PMC5207000__F2 Genetically decreased vitamin D and risk of Alzheimer disease CYP2R1 DHCR7 GC CYP24A1 CYP27B1 PMC8553772__F7 Schematic demonstrating p32 regulates melanoma via AKT/PKB signaling MMP9 CCND1 CDH2 PMC7379631__F3 UPR disease biomarkers and therapeutic targets ATF4 EIF2A CREB3L3 SREBF2 YY1 HIF1A RTCB TRAF2 PDIA5 FOXO1 PMC4593375__F1 The primary epidermal growth factor receptor (EGFR) signaling pathway EGFR GRB2 PTEN MTOR PMC10894836__F4 MiRNAs in Müller cells on retinal regeneration CRX SOX2 TPM1 DKK3 CTDSP1 KLF4 HSPD1 LIN28A ITGB1 PMC10894836__F2 MiRNAs on gliogenesis HMGA2 CCND3 NOTCH3 SOX9 PMC11234281__F2 Piezo1 located in different cells regulates bone formation RUNX3 RUNX2 PPP3CA ROCK1 NFATC1 BMP2 PIEZO1 SOST VEGFA ARHA MYD88 TNFRSF11B MTOR DMP1 NOTCH3 EDN1 FAM20C HP CD80 THBS1 CD68 PMC3238182__F1 Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors EGF FOSL1 ZEB2 EGFR GRB2 TRPS1 PMC8425390__F3 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling BRAF HEL-S-1 RAF1 HRAS PMC5801557__F1 Parathyroid tumorigenesis mechanisms via the cyclins pathway CDKN1B MEN1 CCND1 CDC73 PMC8425390__F1 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling BAD HEL-S-1 EGFR GRB2 BCL2 RAF1 HRAS PMC3116046__F2 Increased expression of DNA repair genes in invasive human pancreatic cancer cells FANCD2 BARD1 ATF1 MRE11A BRCA1 BACH1 IFNG ATM BRCA2 MSH6 RAD51 FANCA MSH2 ATR FANCE PMC5369312__F4 Pediatric Ependymoma: A Proteomics Perspective HMGB1 MPO FOSL1 TP63 HEL-S-99n ENO1 BCL2L1 TAPBP YWHAQ CANX HEL-S-67p GDF15 HEL-S-269 HLTF HBB HEL113 JUNB MCL1 SP1 HEL-S-93 PMC7519545__F1 ABCA1 cell signaling pathways TLR4 MERTK MYD88 ABCA1 PMC5822899__F2 Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue VCAM1 CD40 IL6 RXRA IFNG PMC5822899__F1 The main intracellular pathways and the effects of drugs used in dyslipidemia and obesity in (A) differentiation of preadipocytes into mature adipocytes PDE3B GC LPL TG CD36 PMC7044792__F1 Extrinsic pathway of apoptosis TRADD TNF FADD PMC7044792__F4 HIV-1 and necroptosis RIPK1 IL18 RIPK3 MLKL PMC8632052__F5 Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/Beta-Catenin Signaling Pathway IL1B PMC4694980__F4 Core of kinase-regulated interactomes defines the neoplastic MDSC lineage CBX3 NPM1 TPO AHNAK MTDH HEL-S-130P SDHB PMC8707860__F7 VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway MTOR VEGFB MYOG PCNA PMC4694980__F6 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage ANXA4 TRIR PMC4694980__F3 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage ARHGAP1 HNRNPL BASP1 LRPAP1 ACTN4 PMC4694980__F2 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage HEL57 SERPINB6 NDUFA10 PMC4142901__F1 Hh signalling and cancer: Growth factors can increase the concentration of ligand which prevents the inhibitory effect of PTCH DHH IHH KIF7 SUFU GLI3 GSK3B SHH BCL2 MSX2 PMC2892843__F3 Dual MAG receptor model ARHA LINGO1 PMC8042594__F1 Monocytic and macrophage contribution to SARS-CoV-2 hyperinflammation SOCS3 JAK1 ACE2 IL1B STAT3 PMC9499417__F1 IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy STAT1 BAD GSK3B BCL2 JAK3 JAK1 MTOR STAT3 BAX PMC10489547__F3 Main signaling pathway of cell division cycle 20 homologue (CDC20) in cancers NUSAP1 CDC20 MYBL2 SOX2 WNT3A ANAPC2 WNT1 CCNB1 VHL MIIP UBE2S STAT3 PMC4999903__F8 Sinularin-induced apoptosis in the AGS and NCI-N87 gastric cancer cells BAD GSK3B MTOR BAX PMC8595028__F1 Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway NLRP1 CXCR4 CXCL12 PMC9072740__F4 Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context GPX4 AIFM2 LPCAT3 FACL4 SLC3A2 TF PMC6054262__F1 O-GlcNAcylation regulates oxidative stress signaling pathways ME1 AKR1B10 GCLM FOXO4 GSTA4 KEAP1 SQSTM1 SLC7A11 GCLC FTH1 PSMB2 VHL HMOX1 FOXO1 NQO1 OGA RELA MDM2 PMC8185510__F6 Autophagy inhibition and microRNA-199a-5p upregulation in paclitaxel-resistant A549/T lung cancer cells EEF2K MTOR DKFZp686F0183 PMC9103474__F2 Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis NLK EGF RGCC ZEB2 GSK3B NNMT OLFM4 PTEN STAT3 PMC3429622__F4 TRBP in the exogenous and endogenous RNAi pathways AGO2 DGCR8 DROSHA PMC4001781__F3 Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma BRAF NRAS ARAF PMC4909198__F7 Transcriptome Sequencing and Analysis for Culm Elongation of the World’s Largest Bamboo (Dendrocalamus sinicus) HEL-S-62p CAD PMC5354844__F5 The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis CCR2 JAK3 ARG1 PMC3166354__F1 Cellular and Molecular Action of the Mitogenic Protein-Deamidating Toxin from Pasteurella multocida PIM1 EGFR NOTCH1 ARHA CEBPA RAC1 JAK1 PLCB1 CDC42 PMC3288643__F1 Ephs and Ephrins in Cancer: Ephrin-A1 Signaling PTEN EPHA2 PMC8060460__F1 Process of neddylation modification of proteins UBE2F EGFR MDM2 UBA3 PTEN SMURF1 TGFBI NAE1 PMC9035666__F4 Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1A/VEGF and FAK/AKT Signaling Pathways PIK3R1 RELA MAPK3 MYC MAPK14 PIK3CA SRC MAPK1 TNF JUN STAT3 PMC3533463__F1 Biosynthesis pathways of phospholipid components in archaea IDI2 MVK GIP PMC3882864__F1 The variety of stimuli that can up-regulate NKG2D and DNAM-1 ligands ATM MICB MICA ATR PMC7914548__F2 Host mucosal responses to C IL16 S100A8 CCL20 PMC3937043__F5 Ingenuity Pathway Analysis (IPA) of the 39 differentially expressed genes in MFG transcriptome at 18 hpi vs EGR1 ZFP36 BCL2A1 GADD45A SERPINA1 IL1B CTSZ PMC2698645__F1 Simplified schematic representation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway driven by muscle contraction, insulin, essential amino acids (leucine), and/or energy TSC2 EEF2K TSC1 MAP4K3 EEF2 RPS6 RHEB PMC6220322__F8 Metabolic enzymes that characterize the progression from a normal liver to cirrhosis, which culminates in HCC ALDOB UQCRB FBP1 PFKL HEL-S-87p COX5A NDUFA5 PDHA1 HEL-S-304 HEL-S-133P HK2 HEL-S-281 SDHB PMC2698645__F2 Simplified schematic representation of the interaction between the mTORC1 and ERK1/2 signaling pathways following muscle contraction and/or insulin stimulation TSC2 EEF2K TSC1 EEF2 RPS6 RHEB PMC8818599__F7 Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting SOCS3 FBXO32 IRS1 STAT3 PMC7904555__F2 Intracellular trafficking pathways of TLR4 and TRAM TLR4 GMFG LYST VPS33B ARF6 PMC7904555__F1 Pro-inflammatory signaling pathways of TLR4 NLRP3 CD14 TLR4 IRF7 TRAF3 LBP TRAF6 IRF3 MYD88 IL1B TIRAP PMC5061788__F1 mTOR signalling pathway RICTOR EIF4E MTOR EIF4B PMC4171604__F8 Anti-neoplastic properties of hydralazine in prostate cancer EGF EGFR SRC PMC2702500__F1 Metabolic reconstruction of Db SUCO FH HEL-S-133P PMC7352732__F2 Ferroptosis is the result of an accumulation of lipid reactive species GPX4 ASPH SLC7A11 PRODH SLC3A2 PMC7671541__F6 ED-71 inhibiting NLRP3 inflammasome-dependent pyroptosis in HGFs NLRP3 IL16 TLR4 GSDMD PMC8511224__F2 WNT4 signaling pathway DAAM1 DAAM2 ATF2 APC UNK ARHA ROR2 JUN PMC9102468__F1 LINC00665: An Emerging Biomarker for Cancer Diagnostics and Therapeutics NLK AKR1B10 CIP2A SMAD2 APC EGFR LRP5 LRP6 U2AF2 SP1 PMC7018995__F3 Correlation of molecular mechanisms in CTCL and NSCLC and corresponding simulation results ATM BCL2 BMI1 HDAC1 PMC6405444__F2 Major pathways converging on uncontrolled growth in Drosophila epithelial cells MYC SCRIB PMC7913953__F3 Over- and under-expressed genes are enriched in the human cell cycle pathway PLK1 INS SMAD4 STAG1 DBF4 CDK7 STAG2 CDC20 CDC6 SMC3 CDK2 MDM2 PCNA SKP2 MYT1 PMC7352732__F4 K-ras transcription regulation roadmap GPX4 PALB2 KEAP1 SLC7A11 ENO1 SIK3 ATF3 ADRB2 MTOR BACH1 SIK1 HEL-S-68p HEL-S-162eP HOXC10 ATF4 CRTC2 SLC3A2 HEL-S-133P PLAG1 CAMKK2 PMC5817859__F2 Alternative downstream compounds-induced EGFR-TKIs resistance EGR1 EGFR PTEN MTOR PMC3834200__F7 MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells RET STRA8 GDNF PMC4946798__F2 Probing the complexities of astrocyte calcium signaling MCU TRPM2 PMC5731952__F7 Comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis OBSCN ARHA RHO PMC6372765__F1 Signaling pathways involved in sarcopenia , IGF1R IGF1 SMAD2 GSK3B FBXO40 EIF4E MTOR GDF11 EIF4B IRS1 PMC12001728__F3 Intricate regulatory mechanisms of programmed death 1 in tumor cells FUT8 MDM2 MTOR PMC11076696__F3 GLP-1RAs in reducing macrophage inflammation and foam cell formation NLRP3 UNK NOX4 MTOR CEBPB GSDMD PMC11076696__F2 GLP-1RAs in protecting endothelial cell function VCAM1 TNF PMC8294576__F3 Mitochondrial metabolism regulates macrophage biology NLRP3 CGAS RET TLR9 IRF3 HIF1A IL1B PMC10887252__F5 Molecular mechanisms for the involvement of the JNK pathway in insulin resistance FGF21 NCOR1 ATF2 IL6 IRS1 NR1C1 PMC7352595__F9 Biosynthesis pathway of phenylpropanoid in P CCR7 CAD PMC6305585__F4 APOBECs-mediated RNA editing in cancer development NF1 APOBEC3A APOBEC1 NAT1 WT1 PMC6305585__F7 APOBEC1-mediated RNA editing in metabolic disorders APOBEC1 UNK APOE PMC6305585__F6 ADAR2-mediated RNA editing in metabolic disorders CRY2 FLNA PMC7545690__F1 Flow chart for selecting SNPs in the folic acid metabolic pathway genes MAF FOLH1 TYMS PMC9693075__F1 Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss EGF EGFR GSK3B SHH SMO PMC6449083__F10 ANAC044/ANAC085-mediated pathway involved in stress-induced G2 arrest MND1 ATM RAD51 ATR BRCA1 PMC7456948__F1 MSCs in regulating the IL-10 producing regulatory B cells IL10 EBI3 MSC PMC6305585__F3 ADAR2-mediated RNA editing in cancer development AMFR PCDH9 ADAM12 IGFBP7 COPA SLC22A3 ACTN4 RAP2A SKP2 PMC6305585__F2 ADAR1-mediated RNA editing in cancer development TH CCNI PC BLCAP SUFU TGFBR1 DHFR RSF1 PRUNE2 GABRA3 STAT3 PMC7429633__F2 Pathway to protein phosphorylation and cysteine modification of sarcoplasmic reticulum Ca2+ handling proteins PLN RYR2 CP PMC8068766__F4 Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells SPARC GNS CENPM SET SLC27A2 FOS MTOR ORC3 DTL POLD3 ORC2 TIMELESS GINS4 IL2 DUT CDCA3 RRAGA PMC3143653__F6 Ingenuity pathway analysis of PKCAlpha-CT regulated, MEF2-targetted cardiac mRNAs AIP IL13 LAT2 ATF3 TNF CEBPB SPRR1A KIF6 ENO2 SYK TNS1 IL4 PPARG PMC8884377__F1 Endothelial-Mesenchymal Transition or Functional Tissue Regeneration – Two Outcomes of Heart Remodeling VWF CDH2 ACE2 TGFBI STAT3 PMC5863502__F2 Beneficial effects of immunobiotics on the antiviral innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells IFNA1 STAT2 MPC1 IRF3 TYK2 JAK1 TLR3 MAVS PMC5863502__F1 Antiviral Innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells IFNA1 STAT2 CXCL10 MPC1 TRAF6 IRF3 TLR3 MAVS PMC11975626__F2 Interactions between immune cells and cancer‐associated fibroblasts (CAFs) CCR2 TLR4 MMP2 ACTA2 CYLD CXCL5 CXCR4 IL8RB CCL2 CXCL12 STAT3 PMC4452922__F7 IFN pathway in response to virus infection at 24 hpi IRF9 PIAS1 IRF-1 PSMB8 IFNG BAX PMC11975626__F4 Exosomes between urinary system tumours and cancer‐associated fibroblasts (CAFs) HMGA2 RNF43 HGF EGFR HNRNPA2B1 GREM2 MTOR ABCB1 SOCS1 STAT3 PMC11975626__F3 Symbiotic relationship between cancer‐associated fibroblasts (CAFs) and prostate cancer (PCa) ACLY MTOR SIRT1 PMC8275185__F5 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant RGL3 RGL2 PMC5807036__F2 Tumorigenic proteins significantly upregulated in the IMR-32 cells mapped to the MYCN proto-oncogene, bHLH transcription factor (MYCN) pathway ANGPT2 FLI1 L1CAM IL3 MYC KITLG EIF4E SP1 HIF1A INSR PMC9726313__F8 Network-based pharmacology and molecular docking exploring the “Bupleuri Radix-Scutellariae Radix” mechanism of action in the viral hepatitis B treatment SOCS3 TRADD TRAF3 CXCL2 JUNB TRAF2 FADD NOD2 MLKL SELE IL18R1 ITCH PMC3555235__F4 Predicted pathways by the Ingenuity Pathway Analysis software (IPA) according to microarrays results in peripheral blood mononuclear cells (PBMCs) ATF2 MAPK14 DRD2 CRYAA STAT1 ZFP36 CLCF1 MIA MDM2 SHH GSC IL17C COL18A1 GFAP CYBB GAST VSX1 PTPRN TRH KLF2 BDKRB2 CCL22 MEOX1 CD36 CX3CL1 TMOD2 SENP2 FOXF1 RARA GBP2 APP CXCL6 BAX CD14 NOTCH4 RNF7 NPPA CAMK2D IL13 NFATC1 NR3C1 DBT VPREB1 HPSE HMGA1 MAFA HEL-S-102 BIRC2 NFKBIA CREBBP PSEN1 IL3 CD7 WNT10A PMC4377021__F5 Pathway for a network related to cell to cell signaling process in the anaplastic thyroid carcinoma PLAUR TGFBR1 SDC2 HAS2 GFPT1 HTATIP2 RECQL opn MRC2 KDM1B hCG_2014051 IRAK3 SCD5 PMC4765324__F5 Programming and reprogramming neural cells by (endo-) cannabinoids: from physiological rules to emerging therapies NGF ATF4 TRIB3 ATF3 TRPV1 PMC3852811__F1 Metabolic networks of longevity IGF1 INS PTEN HIF1A PMC5102790__F2 Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma EGF MCC CR1 PMC3163765__F2 Signal Transducer and Activator of Transcription 5a/b: Biomarker and Therapeutic Target in Prostate and Breast Cancer STAT5B PMC12086171__F8 Differentially expressed genes in memory CD4+ T cells from donors expressing HLA-DRB1 alleles KLRF1 CXCL8 LAG3 IFNG KLRK1 GZMA IL7R KLRG1 TXK GZMK IL1RN LTB BTLA CXCL2 CCL4 KLRC1 CTLA4 TIGIT HEL-S-171mP CD27 CCL20 TRAT1 KLRC3 ZAP70 NKG7 BCL2 IL15RA IKZF2 TGFB1 LAT BOLA1 CCL3 PMC9271624__F2 Primary Cilia in Pancreatic Beta- and Alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme TH APC SMO GIP RHO PMC3044438__F3 Identifying genomic and developmental causes of adverse drug reactions in children BHMT2 GGH SLC25A32 FOLH1 SHMT1 MTHFD1 FPGS MTHFD2 HEL-S-61p ADORA2A MTR AHCYL1 MTRR DHFR TYMS HEL-S-70p HEL-S-51e ABCG2 MTHFD1L PMC6508100__F2 MCD genes and cytoskeletal regulatory pathways VLDLR EML1 MAP2 MAP1B CDK5 RHO DAB1 RAPGEF2 NDEL1 PMC4478577__F1 Gut-brain axis for the actions of glucagon-like peptide-1 DPP4 NTS MEA1 PMC2546860__F2 Glycerol biosynthesis and other major pathways contributing to cytosolic NAD+/NADH balance in S HEL-S-49 NDE1 GPD1 PMC9396495__F2 Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma CTSO LTB LPA PMC5216734__F8 Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1 AGO2 SRC RAN PMC6085545__F8 Primary DAEC expansion and differentiation.(A) Proliferating human DAECs and their fate after induction and feeder removal in vitro EGF AQP5 FGF10 SCGB1A1 FGF7 PMC8313741__F8 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression SOX2 SIRT1 PMC8693501__F8 Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells BCL2 ATG101 MTOR PMC3296207__F1 Intrinsic and exrtinsic pathways of anoikis BAD BIK BMF DIABLO FADD PMC7695009__F3 Biosynthetic pathways of UDP-GlcA and UDP-GlcNAc PGM3 UGDH GNPNAT1 PMC84262__F1 IL-1 signaling pathway IRAK2 TRAF6 MYD88 PMC7695009__F5 Overall view of HA roles in the cancer metabolic pathway OGA OGT CD44 PFKFB2 PMC7139586__F5 The proposed role of nAChR signaling pathways in ISC function AFP GIG8 AMOT AREG APC SMAD4 GPR49 SMAD1 PMC9117997__F1 Metabolism and subcellular enrichment of phosphoinositides FIG4 PIKFYVE PTEN OCRL INPP4B INPP4A PMC5267336__F1 Clinical applications of mouse models for breast cancer engaging HER2/neu EGF MYC CCND1 PTEN MTOR PMC2679302__F2 Network contains downregulated genes and identified around NFKB gene MADD SAA1 PYCARD HLA-F PMC5059871__F2 Osteosarcoma cell proliferation is regulated by lncRNAs, including H19, MALAT1, ANCR, and PACER CDK2 ARHA CDK4 PCNA PMC6693703__F1 Mutation‐driven (ligand‐independent) activated Hh pathway in BCC development and invasion SUFU PTCH1 GLI3 SMO PMC4930918__F1 p53 integrates metabolic stress signals to direct cell metabolism TSC2 TSC1 MDM2 PTEN RHEB PMC4930918__F3 p53 directs lipid and amino acid metabolism during stress ACAD11 CPT1C EIF2A ACLY PMC4930918__F2 p53 regulates carbohydrate metabolism during glucose starvation TIGAR ME1 ME2 SCO2 F2 PDK2 GLS2 PMC5818965__F1 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines CCL5 CXCL3 CXCL2 CCL2 TNF CCL1 XCL2 PMC3061571__F2 Two different ubiquitin ligases control the stability of the Aurora-A and Polo-like kinases CDC20 PLK1 APC CDC26 CHFR PMC7683515__F2 Signaling pathways up and downstream of mTOR complexes TSC2 TSC1 GRB2 RAF1 STAT5B RHEB PMC11552340__F3 Compounds that target components of WNT pathway APC TNKS PMC11552340__F1 WNT signaling pathways affected by WNT6 in cancer ATF2 APC PTK7 ARHA RYK ROR2 JUN STAT3 PMC8298276__F1 Drugging multiple same-allele driver mutations in cancer EGF ERBB3 EGFR MTOR PMC3149979__F1 A representative immune response pathway that leads to the disruption of viral release from the plasma membrane IRF7 IRF3 PMC11505556__F11 Therapeutic effect of baicalein against insulin resistance (IR) MTOR IRS1 INSR PMC6344597__F6 The amino acid catabolism pathway differs in breast-fed (BF) and formula-fed (FF) infants HEL-S-62p PMC6273039__F4 The molecular metchanisms of natural polyphenols effects on metastasis CDH2 MTOR GRAP PMC3851989__F4 Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data MYC RAD52 CCNE1 PMC2905316__F2 Involvement of the Notch signaling pathway during endocrine cell differentiation MMD NEUROD1 HES1 PMC3851989__F3 The fourth module identified by iMCMC in the GBM data and locations of the detected genes in known pathways NF1 ChAT EGFR SLC18A3 MDM2 PMC11085419__F5 Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation PCSK9 FOXO3A EGFR LDLR HNF1A WAS PMC12133496__F2 Simple signaling pathway map of SLC7 transporter protein changes affecting Beta-Cell Function and corresponding islet reactions TSC1 IRS1 RHEB PMC9577001__F2 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer CCR5 CD44 CCL2 STAT3 CD24 PMC9577001__F1 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer c-fgr HGF ITLN1 CXCL5 SMAD2 CCL21 GRB2 CD44 RAC1 LPA DLX4 VAV2 PMC5711377__F3 Pathview () plot of the KEGG () pathway showing the Cell mitotic cycle ('HSA 04110') superimposed with RNA-seq expression data corresponding to the log2 -transformed fold change in expression of cell cycle transcripts from HIOs microinjected with E CCNA2 E2F4 WEE1 ATM HEL-S-1 CCNH PRKDC PCNA CDC45 PMC6095977__F1 IRF9 signaling via the JAK–STAT pathway and antagonism by viral proteins STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC3170851__F2 The Multifaceted Roles of Autophagy In Tumors--Implications For Breast Cancer KEAP1 COIL NBR1 PMC4840027__F2 Quantitative regulation by the TCF/Beta-catenin asymmetry pathway POP1 POR TF SYS1 PMC12131380__F7 Working model of this study PRLR CCND1 PRL PMC7440025__F2 Major antiviral functions of TRIM proteins TRIM41 TRIM14 TRIM2 TRIM6 TRIM28 TRIM25 TRIM26 TRIM23 PMC6099292__F5 Ubiquitylated sites in proteins revealed by diGly proteomics in PC9/GR cells PML CLTA EGFR TGFBR1 TFRC RAB11B TSG101 TAP2 CDC27 CLN3 ABCC2 VPS37A ITGB1 ABCA2 SNAP23 PRPF19 PS1TP5BP1 HLA-C USE1 PRKCB TRIM32 VAMP3 CHMP2A ABCC1 CLTC GNAS STX3A STX19 VAMP7 PMC4711826__F7 Molecular explanation YAP1 SMAD2 opn TGFBR1 SMAD4 PMC6198212__F1 Interactions and functions of NRPs HGF TGFBR1 TGFBR2 SRC PMC9238352__F3 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways CD14 NPB CTSK TLR9 MYC IRAK4 IRF3 RAC1 MYD88 TNF TLR3 PDC LEP LBP CD40 REL FADD TIRAP PMC2585593__F1 Diagrammatic representation of pathways associated with aroma production and links to associated metabolic activities ATF2 ADA ATF1 ACD PMC3991635__F6 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells PLK1 GSK3B CCNH SMAD4 CCND3 TFDP1 MAD1L1 CCND2 WEE1 ATM TBC1D8 MDM2 PRKDC YWHAG PTTG1 RBL1 CDC14B UBE2F HEL-S-30 CDKN1B APC HEL-S-92n CDC25B CDKN1C CCNB3 PTTG2 EP300 BUB1B ATR MPEG1 TGFB1 PCNA SKP2 ESPL1 PMC9238352__F5 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways KL HLX DAO MAX REST SPOP PMC5528795__F6 Working model of pyrithione zinc in oral cancer RICTOR BAD CCND1 MTOR BAX PMC9238352__F4 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways CS TRADD LTB TNF POR EDAR LTA BCR ATM HEL-S-11 CYLD LBP LAT PMC5513919__F7 Colorectal cancer metastasis signaling pathway BAD ATR PMC9238352__F7 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways LCK EGFR ZAP70 TRAF6 PTEN JUN LAT TIRAP IFNG BATF PMC9238352__F6 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways BAD PMC3991635__F4 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells CCNA2 PLK1 GSK3B SMAD4 RB1 TFDP1 CDK6 CCNE1 WEE1 MDM2 SET CDKN1B APC GADD45A CDC25B CDKN1C CDC20 CDKN2B CDC6 CDK2 APC2 ATR TGFB1 PCNA CCNH CCND3 MAD1L1 PKMYT1 CCND2 CHEK2 MAD2L2 ATM TBC1D8 CCNB1 CCND1 CDK4 YWHAG PRKDC PTTG1 RBL1 CCNE2 CDC14B UBE2F MAD2L1 CHEK1 PTTG2 CCNB3 EP300 BUB1B CCNB2 MPEG1 SKP2 ESPL1 PMC3567494__F1 Two phosphoinositide cycles regulate aspects of lysosome function PI3 IL1A PC FIG4 PIKFYVE FYCO1 PAH PMC8745298__F2 Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease SP2 ATF4 EIF2A SP1 BDNF TRAF2 XBP1 GLS PMC6453877__F3 HIF-mediated suppression of ROS GCLM SLC7A11 HEL-S-51e COXFA4L2 PHGDH PMC6453877__F4 HIF-mediated regulation of mitochondrial mass POLRMT BNIP3 MXI1 TFAM PMC8656474__F2 Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma APC CD80 CTLA4 LAG3 IRF-1 IFNG PMC6515249__F3 Natural-product-mediated multi-step regulation of the TRAIL-driven pathway STAMBPL1 FADD BAX PMC3207473__F7 Model: TTP transition from “hypo- to hypermodified” determines its functional switch TRADD TRAF2 FADD HEL-S-162eP PMC6515249__F2 Negative regulation of the TRAIL-driven pathway TRAF6 ITCH PMC8791723__F1 Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease IDO1 KYNU KMO IDO2 PMC6515249__F1 TRAIL (TNF-related apoptosis-inducing ligand)-mediated signaling BCL2 BAX PMC6631793__F1 Iatrogenic interference with the initiation of antifungal immunity MAF CXCR1 BTK CARD9 CS BCL10 SYK IFNG PMC9405736__F1 Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage SQLE ACSS2 HMGCR DGAT1 SCD FDPS LDLR SOAT1 ABCA1 ACLY SLC25A1 GLS FASN PMC5748986__F2 Protein sequestration at the nuclear periphery HDAC3 RBBP4 SMAD2 SIRT6 RBBP7 YY1 PARP1 AKTIP WRN HDAC1 PCNA POLI PMC5487527__F3 m6A is involved in viral replicationSchematic representation of the intersection between m6A pathway and viral replication YTHDF2 METTL14 YTHDF1 METTL3 ALKBH5 PMC5487527__F2 Links between m6A regulation and cancerSchematic representation of m6A pathway components and targets involved in cancer progression RARA METTL14 ELF3 METTL3 FOXM1 ASB2 EGFR GSC ALKBH5 PMC7649569__F3 Major milestones in the development of the Hippo signaling pathway HEL-S-11 NF2 PMC9265087__F3 It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer MICB MYC TRIM29 TERT IFNG PMC12083488__F1 Tryptophan metabolic pathway AHRR AHR PMC6138823__F3 Hepatitis C virus-apolipoprotein interactions: molecular mechanisms and clinical impact PLTP ABCG1 LDLR ABCA1 PMC6470603__F8 Compound 3f exerted anti-pulmonary fibrosis activity via repression of the TGFB/Smad signaling pathway COL3A1 SMAD2 PMC8699381__F3 Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches GPR55 ATM HEL-S-11 ATF2 EGFR ARHA XBP1 TRPV1 BAX PMC8322984__F9 Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals NLRP3 IL1B PMC5340232__F7 Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer FILIP1L APC GSK3B LRP5 LRP6 PMC8117616__F7 Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria TSC2 ChAT ITGB3 MDM2 HEL164 VWF GNG11 XB RHOB PMC11767231__F4 Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy CARMIL2 WIPF1 DOCK8 WAS ARPC1B PMC11767231__F1 CBM complex controls T cell signaling by the mammalian target of rapamycin (mTOR), nuclear factor kappa B (NFKB), and c-Jun N-terminal kinase activation (JNK) CARMIL2 CARD11 MTOR CARD14 PMC11767231__F2 The JAK/STAT pathways contain various factors, including STAT5, which leads to myeloid activation, or STAT3, which upregulates transcription of the gene ZNF341 STAT1 ZNF341 JAK1 STAT5B STAT3 PMC9687819__F3 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism CGAS IRF3 IRF-1 PMC7983022__F1 Hepcidin and iron homeostasis ERFE HAMP FURIN MTOR PMC9687819__F2 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism STAT1 OAS1 CGAS RSAD2 STAT2 IFNK IRF9 TYK2 JAK1 PMC9233125__F3 Link between inflammatory mediators, autophagy, and metabolic reprogramming TH GOT2 IL24 CXCL2 PMC5053521__F6 Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier EGFR HBEGF SPHK2 PMC9233125__F2 Genetic alterations induce metabolic reprogramming in PDAC MYC RPIA PMC9233125__F1 Box 1. Molecular subtypes and metabolic reprogramming in PDAC HNF4A GSK3B SIX1 HK2 SIX4 PMC3734370__F1 Regulated secretory pathway of a model neuroendocrine cell SORT1 SCG2 CHGB POMC NGF NPY SCG3 AgRP MC4R CGA BDNF INSR PMC6499807__F9 Mechanistic scheme of lncRNA lnc-TALC in GBM FOXO3A STAT3 PMC6694743__F6 Physiopathology of JCPyV in the brain NF1 EGR1 SP1 HIF1A IRS1 PMC7913544__F2 Functional roles of E3 ubiquitin ligases (blue) and DUBs (pink) in the ER stress and ERAD signaling pathway USP19 USP14 ATF4 RNF186 EIF2A UBL4A RNF183 BNIP1 YOD1 BAP1 PMC9656873__F3 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs TBK1 CGAS IRF3 ACE2 PMC7324671__F7 Proposed working model for IL-21-induced B cell differentiation and IgA-producing plasma cells in porcine Peyer's patches STAT1 IL21R PAX5 BCL6 STAT3 PMC8285903__F8 GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion RAC1 AXL PMC10758279__F2 In Vitro and In Vivo Analysis of Neurotrophin-3 Activation of Arf6 and Rac-1 TIAM1 TAMALIN ARF6 BDNF PMC4900611__F7 HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis BAD NGF TRADD BAK1 PARP1 HUWE1 CASP2 CASP10 DIABLO HTRA2 GAS2 DFFA BIK APP BCL2 SPTAN1 MCL1 CRADD TRAF2 FADD CYCS CASP4 BAX BOK PMC6971376__F4 Pleiotropic role of miR-486-5p in manipulating several target genes in different cellular contexts.miR-486-5p has several targets in different malignant and non-malignant conditions GAB2 SMAD2 TWF1 OLFM4 FBN1 PLAGL2 DOCK1 PTEN PMC9656873__F1 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs NLRP3 CDK2 IRF3 ACE2 PMC7574589__F1 Scheme of mannose metabolism in MPI deficient cell APP PMC2956378__F7 Thrombin-induced ET-1 secretion in RPE is rho/ROCK1/2 dependent ROCK2 ROCK1 GATA4 GATA2 PMC8919593__F8 Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer’s disease ATF2 CTRL JUN PMC11521927__F3 Various signaling pathways activated by TGFB1 stimulation and their partial cross-talk are outlined SPSB1 HEL-S-28 SMAD2 SMURF2 GRB2 SMAD6 SMAD4 TRAF6 PTEN SMURF1 TRAF4 PMC7820616__F7 Survival of salivary gland cancer stem cells requires mTOR signaling RICTOR BMI1 MTOR PMC11941073__F1 GOLPH3 regulates the spatial distribution of glycosyltransferases within the Golgi cisternae GOLPH3 MTOR ST6GAL1 PMC4276909__F1 miRs regulate vascular medial calcification RUNX2 ALK PMC6433576__F1 Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression APC PMC2810550__F2 Wnt signaling pathway involvement in cancer and neurodegeneration APC LRP5 LRP6 PMC12065877__F1 Differentially expressed transcripts mapping to the canonical HIF-1A signaling pathway in shunt PAECs, as mapped by Ingenuity Pathway Analysis Canonical pathway analysis, p-value of EPO ELOC IGF2 VHL EIF4E HIF1A RBX1 FOXP3 ARD1A CDKN1A COPS5 APEX1 MDM2 NCOA1 NOS2 RPS6 RAN TGFA JUN ADM TF PMC8531525__F1 Targeting Microglial Alpha-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease NLRP3 SNCA TLR4 SIRT3 PMC4259953__F3 Possible mechanisms of expression and functional regulation of tissue factor and coagulation factor VII in breast cancer cells EGR1 USF1 F3 EGFR PTEN MTOR TF PMC4792035__F1 Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair EGF BTC AREG EGFR HBEGF TGFA PMC4867399__F2 Illustrated summary of Hedgehog pathway and its effetcs at different stages in the formation and progression of ductal pancreatic carcinoma CXCR4 SHH SMO IL6 RAF1 CXCL12 PMC4270428__F1 Multitask Learning of Signaling and Regulatory Networks with Application to Studying Human Response to Flu NPM1 MYC HEL-S-101 FOSL2 CRKL SOX9 SIAH1 ATM POLR2A POU2F1 UBE2I MDM2 SP1 MVP BHLHB2 NCL TUBB TRIM2 CEBPA TRIM25 DDB1 CRK PS1TP5BP1 CREBBP KHDRBS1 STUB1 SP4 RELA HEL113 TRIM28 COMMD1 SP3 PCNA PMC6393348__F2 Activated STAT3/5 signaling pathway by IL-6 receptor, Prolactin (PRL) receptor, VEGF Receptor, EGF Receptor, and IL-10 receptor EGF PRLR EGFR PRL STAT3 PMC3412972__F2 Proteins and protein isoforms in glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, galactose metabolism, and glutamine metabolism pathways CS GCK PFKM FH ACO2 RPIA PCK2 SUCLG2 PFKP RPE HEL-S-133P HEL-S-281 ALDOB HK3 FBP2 G6PC2 PGM2 FBP1 ENO1 DLD PFKL HEL-S-87p SRM GALK2 HEL107 GLS PMC7894404__F1 Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes UGT1A9 CYP3A4 UGT2B7 PMC12059460__F6 HPE inhibits allergic rhinitis by modulating the AMPK/SHP1/SHP2/STING signaling pathway TBK1 EGFR SYK PMC7672255__F2 CYP1B1 as a therapeutic target in cardio-oncology AHR CYP1B1 PMC12163474__F14 Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements BACE1 STAT1 GFAP APP BCL2 ACHE TNF IL1B BAX SIRT3 PMC6066739__F1 ERA subcellular localization allows the activation of both nuclear and membrane-initiated signaling pathways SRC SP1 TF PMC6672276__F11 Regulation of vasopressin gene expression in the SCN VIP PMC9570066__F7 Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio FOS RAF1 STAR PMC11543427__F3 The formation of VSMC-derived foam cells induced by ox-LDL TFEB SIRT6 LYN ABCA1 CD36 PMC8198168__F2 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer KDM3A MYC KDM4C EZH2 MTOR GLS PMC8198168__F1 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer KDM1A HEL-S-133P GLS PMC5656721__F3 Interplay in the synthesis and actions of the 2-acylglycerols and ethanolamides derived from ARA, DHA and EPA GPR55 ABHD4 PTPN22 TRPV1 PMC8642436__F6 A potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway MTOR HMGCR FASN PMC4581242__F1 UPRmt models in mammalians NRF1 EIF2A NDUFB2 YME1L1 HTRA2 CLPP PMC2527273__F2 The signaling pathway of Type II, FasL signaling-induced apoptosis, adapted from Bagci et al CASP3 CASP9 CASP8 BAX PMC10152985__F15 Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications UBC UBA6 HUWE1 UBA7 UBA5 WWP1 RBX1 TRIM25 FBXW7 NEDD4 SKP2 BAP1 PMC4365348__F5 Shared pathway/ GO categories for DEGs from liver and skeletal muscle tissues EIF4A1 MAPK3 MAPK14 VHL RPS26 RPS29 EEF1G FAU RELA EIF4B RPS12 RPS21 RPS23 PMC7873896__F4 Therapeutic molecules that target Wnt signaling pathway at the level of the plasma membrane WNT1 LRP5 LRP6 DKK1 PMC9421153__F5 Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma EGF FGF2 EGFR VEGFA IL6 MTOR IL6R IL1B PMC7873896__F2 Wnt signaling pathways at the plasma membrane RNF43 CDK14 APC GSK3B LRP5 LRP6 RYK GPR49 PMC11983633__F6 Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway MICB MICA RPL9 PMC2605957__F7 Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway HGF POR CD36 PMC3621649__F1 Targeted therapy pathways.Notes: Protein kinase B (AKT) is a serine/threonine-specific protein kinase that affects glucose metabolism, apoptosis, cell proliferation, transcription and cell migration STAT1 STAT2 MTOR STAT3 PMC7958478__F2 Pathways linking coronavirus disease 2019 to heart/brain injury IL15 CXCL10 IL22 IL6 PMC2886346__F10 The pathway signaling to ERESs NF1 EGF MAP3K1 EGFR PMC4957615__F1 Actin and myosins in mammalian autophagy HEL-S-62p WHAMM MYO6 MYO1C OPTN PMC7218174__F3 Autophagic compensation in resistance to MET-targeted therapy ULK1 HGF MTOR GLS PMC4951264__F8 Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways CCND1 MCL1 PMC6999540__F1 An overview of metabolic engineering of Y ME1 XK XDH LPA TNLG7C PEX3 IPP GPD1 PMC2784662__F1 mTOR Signaling Cascade RICTOR ELF3 PTEN EIF4E MTOR RHEB PMC8628461__F5 Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse MICB ICAM2 CD48 TNF HLA-B HLA-C CASP3 RAE1 HEL-S-11 GRB2 MICA SYK LAT MAL PMC5814270__F5 Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas RGCC LIF EGFR CTF1 IL6ST CDC2 PMC3158334__F1 Possible mechanisms of opioid receptor mediated influence of morphine on tumor growth EGF BAD MOS CCND1 SRC ARHA PMC11177111__F0 miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL HMGCL CCND1 PMC9604112__F1 Etiology of IBD—Is It Still a Mystery? APC CCL20 HEL-S-92n PMC7439917__F1 ACE2 downregulation by SARS-CoV-2 induces pericyte damage and microvascular dysfunction ACE2 ADAM17 TMPRSS2 PMC2633485__F8 Proposed mechanism of PDGF signaling in the lens epithelial cells EGFR GRB2 SRC PMC4394028__F1 TLR/IL-1R, RLR, cGAS, and inflammasome signaling pathways CGAS TLR5 NAIP NLRC4 IRAK1 IRAK2 IRAK4 IRF3 MYD88 TLR3 NLRP3 TLR8 TLR4 AIM2 IL1B MAVS MAL PMC7678304__F3 Literature-based illustration of TNFA signaling pathway in the presence and absence of macrophages CASP9 CASP8 STAT3 PMC8234951__F3 Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer MTOR STAT3 BAX PMC6660575__F1 Posited mechanistic frameworks implicating dietary carbohydrates and cancer risk IGF1 SHBG PMC8239365__F5 IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme IGF1R AEBP1 MMP9 EGFR VEGFA PTEN MTOR OSMR STAT1 MMP2 PDGFA IGFBP2 JAK1 JUN STAT3 PMC8070923__F2 Main mechanisms by which active skeletal muscle can impact the brain BDNF SIRT1 FNDC5 PMC6212468__F2 Integrin linked kinase (ILK) signaling HEL-S-11 RHO PTEN PMC12067395__F2 Interactions between tumors and copper ATP7B HEL-S-30 ATOX1 EGFR MYC CCND1 HEL-S-44 HEL-S-133P PMC2873428__F8 Sequencing, Analysis, and Annotation of Expressed Sequence Tags for Camelus dromedarius KEAP1 GSK3B PMC9659858__F1 Clinical implication of genetic composition and molecular mechanism on treatment strategies of HER2-positive breast cancers TSC2 PAK1 TSC1 CCND1 BCL2 CDK4 IL6 PTEN CCL2 CDK6 BAX PMC7459525__F6 The possible FDNCR1-miR-204-TGFBR1 pathway in porcine preadipocyte differentiation SMAD2 TGFBR1 PMC11743317__F6 Signaling pathways of duck RIG-I in gene-edited DF1 chicken cells IRF7 IRF3 TRIM25 IRF-1 TLR3 MAVS MX1 PMC6212468__F3 Rho GTPase family signaling HEL-S-11 UNK MOK WAS RHO PMC8431732__F2 Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases DPP3 FYN PALB2 AHR KEAP1 SQSTM1 MYC SP1 PGAM5 JUN BRCA1 PMC3303610__F3 Ang-(1-7) signaling in cardiomyocytes GSK3B PMC2886330__F1 Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells EGFR PTEN MTOR PMC6212468__F8 Main effects on pathways in the metabolic syndrome hearts (DKO) versus WT hearts and for both mouse models the effect of ACE-I EGR1 CREBBP FOXO3A NFAT5 FOS ATF2 RELA TP63 CREB1 CEBPA NR1C1 PMC3883963__F3 HMGB1-TLR4 signaling mediates liver I/R injury CD14 HMGB1 TLR4 TNF PMC8849213__F2 Protein C Pathway in Paediatric and Neonatal Sepsis CD14 TLR4 PC LBP IL6 IL1B TF PMC6521864__F3 Synthesis pathway of cardiolipin from lysophosphatidic acid and lysophosphatidylcholine PGP PTPMT1 HEL-S-5 PMC6733035__F1 Lineage of Cytotoxic Innate Lymphocyte Differentiation CILP IL15RA PMC5806469__F5 Extended compartmentalized lignin pathway model in B CAD PMC7060546__F3 Roles of (P) RR in pathways that contribute to oncogenesis, as well as cancer progression and metastasis APC LRP6 MTOR PMC5806469__F1 Putative lignin biosynthesis pathway with identification of species-specific reactions SI CAD PMC11351712__F7 Graphical abstract PTCH1 SHH SMO H2AX BAX PMC6150077__F1 Diagram of gemcitabine metabolism and proposed mechanisms of gemcitabine resistance RRM1 RRM2 PMC5859839__F7 Pathway o of DXP-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) IGF1R BRAF NR3A2 HSP90AB1 MAPK14 MTOR FGFR2 INSR AK2 RADX BTK MAPK12 KDR MMP2 STS PTPN11 SRC IL2 NOS2 SELE MAPKAPK2 KIT MMP9 ARHA EIF4E TNF HMGCR RXRA CALM1 MAP2K1 LCK ZAP70 GRB2 JAK3 SYK RAF1 PPARG PLA2G10 CDC42 PMC4519954__F13 Endocytosis signaling pathway TSG101 EGF PI3 VPS25 EHD3 LDLR ARHA VPS28 ARF6 VPS36 CBL PMC4519954__F12 Lysosome signaling pathway GNS NAGPA GALNS AGA NAGA ABCA2 IDUA GAA GUSB PMC4519954__F11 ERBB signaling pathway EGF NRG3 BAD NRG2 MYC SHE HBEGF NRG1 MTOR CRK CBL BTC GRB2 NRG4 JUN PMC4519954__F10 MAPK signaling pathway CD14 MOS DAO MAX FLNA ATF2 GRB2 TRAF6 ECSIT JUN PMC5734789__F8 Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination HES5 MBP HDAC1 PMC7451686__F1 Working model for mTORC1/p70S6K signaling regulation of Beta-TrCP-mediated PD-L1 degradation SKP1 MTOR DEPTOR MLST8 PMC7762487__F8 PPI network and KEGG pathway analysis for the differentially expressed MAM proteins in PSD and PDZ rats CAPZA2 HEPACAM HEL-S-30 APOO RALA EEF1A2 PSAP TMED10 HEL-S-130P GNG12 HEL-S-162eP OMG ARHG COX2 VAPA ND2 MAPK1 PSMD2 STX12 APOE NEFL PMC3444437__F9 C-srcregulating primordial follicle activation and growth through PI3K → PKC → MAPK signaling pathway SI SRC GNAL PMC5805631__F5 Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target IL13 ENG DKK1 IL6 MTOR TSLP RPTOR IFNG RICTOR NGFR IGFBP1 SELE STAR PMC3581417__F1 Synthesis of DNA precursors in the cytosol and mitochondria TK1 PMC4973221__F3 Transcriptome landscape of Synechococcus elongatus PCC 7942 for nitrogen starvation responses using RNA-seq PC PGM2 RPIA POR PGAM1 SDHA PMC9329168__F1 Improving Treatment Options for Primary Hyperoxaluria DAO HEL-S-133P PMC11756006__F1 Molecular signaling of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 priming and activation NLRP3 MYD88 GSDMD PMC7057842__F2 Post-Translational Regulations of Transcriptional Activity of RUNX2 PIN1 RUNX2 GSK3B CDK4 PMC5664350__F4 Summary of intracellular TLR4 signalling in platelets TLR4 IRAK1 IRAK2 GC TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC5664350__F3 Summary of intracellular TLR4 signalling pathways in nucleated cells CD14 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC153558__F3 Model of the maternal Radar signaling pathway mediating early steps of dorsoventral axis formation BMP7 SMAD1 DKFZp781O1323 BMP4 PMC3743157__F3 RB1 pathway indicating genes with mutations in this series SUFU PTCH1 SMO CDK4 RB1 CDKN2A CDK6 PMC3112459__F1 TGFB signalling pathway and breast cancer susceptibility SMAD2 TGFBR1 LTBP2 SMAD6 TGFBR2 SMAD4 LTBP1 SMAD1 TGFB1 DKFZp781O1323 PMC11756006__F2 Molecular and cellular signaling pathways of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 in obesity, diabetes, and other metabolic diseases NLRP3 TLR4 IFNG CD36 PMC6314136__F6 Dynamic gene expression profiles of CIK cells involved in the cell cycle and the natural killer cell–mediated cytotoxicity pathway HEL2 HEL-S-1 SMAD2 GSK3B SMAD4 RBX1 STAG1 CCND3 DBF4 ORC3 E2F3 STAG2 CDC45 ORC2 CCND2 CASP3 CDC6 CDK2 PCNA SKP2 PMC8833717__F3 Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer BAD BAX PMC4701085__F10 Molecular pathways affected by Gcm NUMB HEPH SMO RDX PMC4261819__F1 Network of noncoding RNAs negatively regulates NFKB signaling BTRC IRAK2 KLF4 TRAF6 CD40 IRAK4 KLF2 CARD10 MYD88 MAP3K7IP1 TAB3 PMC6150077__F2 Diagrams of the Hedgehog, Wnt, Notch pathways and their roles for gemcitabine resistance SUFU APC GLI3 SMO PMC5859839__F3 Pathway of ER-positive breast cancer target PPI network (blue circle stands for breast cancer gene; red diamond stands for pathway) MYB EGF ELF5 PLK1 NR3A2 YAP1 PTGS2 EGFR MYC EIF4E MTOR STAT5B PAK1 IGF1 KDR SRC PIK3CA CCND1 BCL2 PPP2R2A SIRT1 PMC5037530__F1 The gSkM transcriptome for the comparison of HFD-ED and HFD-corn oil fed mice SDHC NDUFS6 CPT2 HEL-S-5 HEL-S-26 ACADL CPT1A ACADVL NDUFB7 PDHA1 NDUFB10 NDUFB3 PPA2 SUCLA2 OGDH COX7B DLAT NDUFB5 ACADM SDHB PMC11005242__F7 GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway PMC7348946__F3 Simplified overview of the CD28, PD-1, and TCR signaling pathways in T cells TBX21 CD80 LAG3 PMC11697715__F3 Histone lactylation changes in tumor-associated macrophages TRAF6 ARG1 PMC7348946__F2 Simplified overview of the TCR and CD28 signaling pathways in T cells LCK CD80 PMC7348946__F1 Simplified overview of NK cell activation by the NKG2D pathway ULBP2 MICB VAV1 GRB2 ULBP1 MICA ULBP3 PMC10983073__F3 Diagram of the inhibition of TSLP Signaling by HZ-1127 and TEZE JAK1 TSLP STAT3 PMC9433749__F1 Gearing up for battle: Harnessing adaptive T cell immunity against gram-negative pneumonia CXCL1 AREG APC PMC4282639__F6 Chronic exposure to TGFB1 regulates myeloid cell inflammatory response in an IRF7-dependent manner CXCL1 IRF7 TGFBR1 CXCL2 TGFB1 PMC4756317__F6 GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway GAL WT1 SSR2 PMC3657472__F1 Genetic predisposition to peripheral nerve neoplasia: Diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes RET CD44 PMC8408559__F5 Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer PAX2 NPM1 GAS7 CCL2 PAX3 OLIG2 TXN MAF BCR PAX5 MDM2 HEL-S-133P PAX1 FLI1 PLG ERG CCL4 POU2AF1 GAST BRCA1 tal-1 RHOBTB2 LEP TSC1 AXIN1 STK11 BCL2 CCL22 CREB3L2 TEP1 RELB LATS1 LATS2 CLU PIM1 HEL-S-67p LDLR CAV2 ETS2 RUNX1 SDC1 PDGFRA IGF2 VHL FGFR3 RRAS2 MCF2L GATA4 GATA2 CBL PIM3 EVI1 TXNIP PLEKHG2 SP3 STAT3 PMC5762387__F5 MEF2 signaling and human diseases PLCG1 PLCB3 MEF2B EGFR MEF2C MEF2D PMC4402595__F2 Relationship between the genes in each module from the GBM dataset QK3 CDKN2B DKFZp781B1423 EGFR MDM2 PIK3CA CDK4 PTEN RB1 CDKN2A CYP27B1 PMC2756045__F2 LKB1-AMPK pathway: metabolism and growth control in tumor suppression TSC2 MAP2 HNF4A SNRK KSR1 CRTC2 HDAC5 IRS1 PMC9160826__F1 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma GPX4 LPCAT3 ASCL4 HMOX1 PMC2756045__F4 LKB1-AMPK pathway: metabolism and growth control in tumor suppression MAP2 APC CDC42 PMC2756045__F3 LKB1-AMPK pathway: metabolism and growth control in tumor suppression NF1 TSC2 TSC1 IGF1R PTEN EIF4E MTOR EIF4B IRS1 RHEB PMC2884012__F1 Tuberous Sclerosis Complex: A Brave New World? TSC2 TSC1 PTEN RHEB PMC11932036__F1 Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review NOTCH2 NOTCH4 NOTCH1 NOTCH3 PMC7714932__F4 Vascular diseases: the roles of miR-21/miR-21-3p in ECs and VSMCs TPM1 PTEN SP1 ADRA2B NR1C1 RHOB PMC3206195__F3 Fear Conditioning, Synaptic Plasticity, and the Amygdala: Implications for Posttraumatic Stress Disorder FRS2 BDNF PMC7714932__F3 Cardiac hypertrophy and HF: the roles of miR-21/miR-21-3p in CMs, CFs, and ECs HDAC8 GSK3B SPRY1 PTEN PMC9423097__F2 Interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis NLRP3 FOXP3 PMC4536758__F1 Idelalisib —targeting PI3KD in patients with B cell malignancies CXCL13 BCR CXCR4 CXCR5 SYK CCL4 CXCL12 CCL3 PMC4467301__F1 Epithelial–mesenchymal interactions mediated by Sonic Hedgehog pathway in embryonic lung NOTCH2 SIRPA GRINA COL18A1 FLT1 PTCH1 ESM1 SHH SMO PECAM1 IL1B FOXF1 PMC7465890__F10 Asp metabolism after enteral administration within the small intestine (a) and liver (b) and postulated metabolic pathway of Ala in periportal hepatocytes CIT CP MAL PMC7714932__F2 Ischemic heart disease: the roles of miR-21 in CMs and CFs.Reported major signals in CMs MMP2 SMAD2 PTEN PMC4087218__F4 Resveratrol on protein phosphorylation in the insulin signaling pathway and the mTOR pathway of obese mice PTEN EIF4E MTOR IRS1 PMC10093079__F7 Baicalein inhibits cancer cell progression by targeting P13K/FOXO pathways PTEN MTOR BAX PMC4582667__F1 Phosphatidic acid: a new therapeutic lead to suppress hepatic glucose production PC LPA PMC2777795__F2 Negative-feedback loop linking NAD+/SIRT1 with the Clock network NAMPT SIRT1 PMC4519954__F14 Chemokine signaling pathway DAO GRB2 SHE ARHA CRK PMC10093079__F5 Baicalein in regulating the cancer signaling pathways ATF2 MDM2 ERF MTOR PMC9160826__F2 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma GPX4 FACL4 KEAP1 FTH1 CISD1 GABPB1 NQO1 ZFP36 MT1G IREB2 PRDX5 CP HCAR1 PMC8273767__F5 Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks VASP BAD FYN HEL-S-28 GRB2 SHE ARHA CRK CDC42 PMC3430547__F4 TORC1 and nitrogen regulation NPR2 NPR3 MKS1 MAF1 PMC7432414__F6 Putative signaling pathway involved in HRPC–CAF transition mediated by PDGF-BB increase CCL18 CXCL11 PMC2172491__F1 The PI3K–Akt–TSC–TOR pathway and feedback regulation of insulin/IGF-I signaling BAD INS EIF4E PMC8302486__F3 Interferon B, an enhancer of the innate immune response against SARS-CoV-2 infection RNASEL OASL STAT2 ISG20 IFITM3 IRF9 TYK2 JAK1 PMC8684386__F3 Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses CTCF GC ATF3 RIGI SP1 MAP3K7IP1 LAT PMC9162456__F3 Natural and engineered metabolic pathways to biofuels AHR TES FAP IPP ADM ACR PMC4944541__F2 Crosstalk between leukemia cell and BM MSCs VCAM1 MSC RELA CCL2 PMC6692187__F1 IRE1A structure, activation and potential roles in cancer SPARC VEGFA ID1 TRAF2 XBP1 PMC9502172__F8 HSP27 Attenuates cGAS-Mediated IFNB Signaling through Ubiquitination of cGAS and Promotes PRV Infection TBK1 CGAS IRF3 PMC8234554__F2 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses NLK AMOTL1 CRB3 ARHA LATS1 LATS2 PMC8808072__F9 Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use PIK3CD PIK3R1 EGF IGF1R MAPK9 BAD HGF BRAF MAPK8 MAPK3 ACTN1 GSK3B BCL2L1 PTEN PDPK1 PRKCA opn SRC MAPK1 JUN VEGFA MAP2K2 HRAS PIK3R3 DVL1 MAP2K1 PRKCB PIK3CA BCL2 VEGFB AKT3 APPL1 PMC2695822__F10 Display of genes with high expression in CT embryos PALLD MTCH2 NTS GH1 PMC8306625__F4 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases IRF7 TRAF3 DUOX2 IRF3 MAVS GLS PMC4001295__F7 Opposing TNFA/IL-1Beta- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation RUNX2 BMP2 SMAD1 IL1B DKFZp781O1323 PMC3270058__F9 Endothelial adaptive response to moderate hypothermia (25°C/72 h) HMGB1 TH NAMPT PDIA4 NASP ENO1 L3MBTL2 RRM1 TPRX1 HNRNPDL BANF1 ZNF224 IMPDH2 PMC7643190__F1 Biomarkers, molecular pathways, existing and emerging therapeutic targets in colorectal cancer EGF BRAF APC EGFR MTOR PMC3065454__F8 Advanced Computational Biology Methods Identify Molecular Switches for Malignancy in an EGF Mouse Model of Liver Cancer EGF FOXO4 STAT2 IGF2 ATF1 TRAF6 IRS1 INSR NLK PAK1 ATF4 GRB2 SRC ADAM10 JAK1 GATA3 STAT3 PMC8421619__F1 Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol CYP2B6 CYP3A4 PMC5901475__F2 Therapeutic approaches for Treg enrichment in vivo NR1i1 IL33 CCR4 MTOR CCL22 FOXP3 PMC6514096__F4 Interconnection of the pathways studied, the genes in which we have measured expression and connection to mitochondrial respiration PINK1 MFN2 ADA PTEN EIF4E HIF1A MTOR SIRT1 UCP2 SIRT3 PMC7224208__F8 Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues STAT1 IRF7 UCP1 ATF4 MYC SREBF2 IRF3 IFNG PMC11554266__F3 This illustration details the PI3K/AKT/mTORC1/HIF1A pathway, focusing on its regulatory role in glucose uptake through GLUT1 and GLUT4 transporters EGFR HIF1A PMC4066219__F2 IL-15: a central regulator of celiac disease immunopathology JAK3 FOXP3 PMC7438559__F12 Working model of the experimental validation IGF1 MTOR DKFZp686F0183 BAX PMC11827889__F1 TrkA/NGF/NRP1/GIPC1 targeting for pain treatment NGF NRP1 PMC8144624__F5 Health monitoring in birds using bio-loggers and whole blood transcriptomics CHUK ATG12 MAFK CYLD CXCL10 NLRX1 INTU DKFZp686F0183 PMC2713013__F3 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES TBK1 CD14 TLR9 IRF7 IRAK1 UNC93B1 TRAF3 TRAF6 IRF3 MYD88 TNF TLR1 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 MAL CD36 PMC4141456__F1 Anti-microbial responses MYD88 REL FADD PMC316759__F5 Regulation of reproductive growth and metabolism by the DAF-2 insulin receptor-like signaling pathway PI3 IGF1 PDK2 PMC2713013__F7 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES IRAK1 TRAF6 IRAK4 MYD88 IL1B PMC8234554__F3 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses PIG59 CSF3 AREG CXCL5 MYC ARHA IL6 CCL2 LPAR3 COX2 ELMO3 MED1 ARHGAP29 CSF2 CSF1 CDK9 AXL HK2 PMC8108028__F1 BRCA mutated pancreatic cancer: A change is coming PALB2 ATM BRCA2 RAD51 BRCA1 PMC10451182__F2 Intrinsic and extrinsic apoptotic pathways and confirmed target genes of miR-106a PTEN TNF FADD FAF1 BAX PMC6505570__F1 Myxoid liposarcoma: it's a hippo's world PLK1 FOXM1 YAP1 LATS1 LATS2 PMC3469622__F1 Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells ITK BCL10 CSK FOS LCK GRB2 REL JUN PMC3889810__F6 Whole genome and gene set enrichment analysis of cells expressing mutants of neuroserpin show an upregulation of the cholesterol pathway when polymers are expressed SQLE PMVK MVD DHCR7 FDPS FDFT1 SREBF2 MVK IDI1 HMGCS1 CYP51A1 HMGCR PMC8120202__F5 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS HMGB1 SMAD2 LRP5 SMAD6 SMAD4 LRP6 NOX4 PTEN NACA FOXP3 TSHR RASGRP3 TERT BRD4 PMC8120202__F4 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS PIGU CD63 ARF4 SRC PTEN VCP PMC4399414__F11 Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech LBP TRAF6 IRAK4 UBE2D2 PMC8120202__F3 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS HMGB1 FOS PMC8120202__F2 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS SMAD2 LRP5 SMAD4 NOX4 LRP6 CSA2 FOXP3 PMC6070887__F2 Metabolic rewiring following T cell activation IL10 IL6 MTOR IFNG FOXP3 PMC5400530__F1 Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old APC APOC1 HFE LPA MTTP APOB HP APP KHDRBS2 PPARG TGFB1 APOE HEL30 PMC3782519__F1 MicroRNAs as novel immunotherapeutics EGF EGFR MAPK3 MAPK1 TYK2 SHC1 STAT3 PMC3342562__F6 Schematic representation of the role of H2S in atherosclerosis VCAM1 CCND1 PMC8042400__F2 Biosynthesis of VLC-PUFA and VLC-SFA ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL7 ELOVL2 PMC6710239__F1 Before binding by a Hedgehog family ligand (most often Shh, but also Ihh or Dhh), Ptch1 and presumably Ptch2 maintain Smo sequestered, by a currently unknown mechanism BOC CDON SUFU GPR161 GLI3 SMO GAS1 IFT172 PMC9047687__F7 Whole Transcriptome Profiling of the Effects of Cadmium on the Liver of the Xiangxi Yellow Heifer UBC TSC2 PLTP UCP1 F2 HEL-S-28 ACP7 LPL SHE POC1A CD36 PMC3191732__F1 Cyclooxygenase pathway of AA metabolism LTA COX1 COCH PMC9935926__F7 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions PGP EGFR OLFM4 BNIP3 TGFA PMC9371632__F2 Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection TBK1 CGAS IRF7 IRF9 TRAF3 TRAF6 IRF3 IL6 MYD88 TLR3 TLR7 TYK2 TRAF2 ACE2 MAVS PMC4831116__F1 An overview of plant hormone signaling networks and their crosstalk in stress responses MYB MYC ERF RGL2 PMC7506139__F3 BCAAs and fatty acids regulating inflammatory signals NLRP3 IL1B PMC9935926__F3 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions SSB PTEN MTOR STAT3 PMC5724014__F6 Mechanisms of cytokine-induced dysfunction and death of insulin-secreting cells mediated by intracellular S1P BAD PHB2 IFNG PMC9140571__F9 Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed ITK FYN BCL10 LCK GRB2 CD48 CDK4 CTLA4 LAT CBL PMC5609576__F1 Cross-talk between adipocytes, macrophages, and cancer cells modulating the tumor microenvironment CXCL1 IL33 CCL5 CCL4 CXCL2 CCL2 TNF IL1B PMC7352181__F4 Angiotensin-associated immunoinflammatory pathways in lung tumor microenvironment ACE2 PMC7352181__F3 Angiotensin-associated pathways involved on hypoxia and angiogenesis in lung tumor microenvironment EGF MTOR ACE2 TGFA PMC7352181__F2 Angiotensin-associated pathways associated with cell proliferation, invasion, and migration in lung tumor microenvironment ACE2 STAR PMC11635172__F3 Molecular mechanisms of the immune response are involved in the progression of ALD CXCL1 TLR4 LCN2 CXCL8 IL1B PMC5991421__F1 Computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention HEL-S-62p CD59 FH C7 C6 CR1 PMC7352181__F1 Renin-angiotensin system, its interaction with tumor hypoxia and angiogenesis and subsequent functional impact on tumor phenotype ACE2 HEL-S-130P PMC11635172__F2 Related pathway mechanism of pyroptosis, necroptosis, and ferroptosis in the occurrence and development of ALD NLRP3 RIPK1 GPX4 SLC7A11 RIPK3 TXNIP SLC3A2 FNDC3B MLKL GSDMD PMC5985737__F3 Relation of the studied NAFLD risk alleles to the main pathways in hepatic triglyceride partitioning PNPLA3 TM6SF2 GCKR HEL-S-70p TG LYPLAL1 PMC5072284__F6 Activation of phenylpropanoid-biosynthesis pathway in response to cold storage CS FH SKI CAD PMC8955828__F1 Autophagy Pathways in the Genesis of Plasmodium-Derived Microvesicles: A Double-Edged Sword? DKFZp686F0183 NBR1 PMC4918128__F7 Networks of candidate cancer genes predicted by MUFFINN and their direct neighbors on HumanNet FBLN2 CSNK2A1 FLT4 NRAS HNRNPL FBN1 VPS33B LRPPRC PTEN CHD4 TTN MTA2 RANBP2 CACNA1A CACNA1C KATNA1 NF1 EPHB1 CSF1R MMP2 MYO3A VWF ALG6 SPEN CDK4 THBS1 MKI67 PRPF8 ROS1 TRIO PTK6 LRRK2 AEBP1 PDGFRA PA2G4 DLG2 VCAN WNK1 VHL DDB1 SUZ12 EED SULF1 BCOR EP300 KALRN MYOM1 TEX10 PMC8616391__F1 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It HAMP CD44 PMC3859141__F2 Molecular Pathways: Sterols and receptor signaling in cancer DHCR7 EBP EGFR LDLR SMO ABCA1 PMC8616391__F2 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 MT1G HEL-S-64p FTL SLC3A2 HMOX1 PMC3859141__F1 Molecular Pathways: Sterols and receptor signaling in cancer EGFR LDLR MTOR PMC3500863__F3 Pathways regulating NEKs in cell cycle control NEK6 PLK1 ATM NEK2 RAF1 CDC2 NEK11 ATR NEK9 PMC3796213__F2 Connectivity map of NRF2-mediated oxidative stress response adapted from IPA software MAF GCLM KEAP1 GSK3B HEL-75 CRAT HEL-S-107 UBB PMC3947043__F1 Molecular alterations and biomarkers in colorectal cancer SOCS2 RUNX3 BRAF CACNA1G NEUROG1 APC IGF2 TGFBR2 PIK3CA PTEN PMC2695927__F4 Bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease CD14 OMP LBP BPI PMC4118485__F7 Simplified schematic showing the proposed mechanism of how SEs may suppress cellular immunity and antitumor responses JAK3 STAT3 PMC7583816__F1 Diagram of proposed Pi-induced PP2A/Src/DAPK-1/TPM-3 signaling pathway TPM3 SRC PMC12186155__F1 Proposed mechanism of schaftoside anti-inflammation effects through the NFKB signaling pathway in LPS-induced inflammation on RAW 264 COX2 TLR4 IL6 PMC8784222__F2 COVID-19-diabetes mellitus molecular tetrahedron TLR4 DPP4 GIP IL6 LPA MTOR ACE2 CD36 HEL-S-5 PMC9652018__F1 Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia BAD BIK BMF BAX PMC8784222__F3 COVID-19-diabetes mellitus molecular tetrahedron UCP1 ACE2 UCP2 PMC4415581__F7 TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway TIGAR ATM CDK5 PMC8733431__F7 NETME: on-the-fly knowledge network construction from biomedical literature MCTS1 EGF PGR EGFR MAPK3 DOCK8 MYC IRAK4 RHO HMOX1 ADAM17 IL18 MMP2 ANXA2 SRC MAPK1 hEMMPRIN ABCG2 SLC16A4 SP1 S100A4 PLG WASF1 AREG MMP9 VEGFA CD44 RAC1 IL6 HEL-S-69p MMP14 IGF1 TNFSF11 NFKB1 CAMLG PIK3CA SLC2A4RG SETD2 CSF1 TGFB1 SP3 PCNA STAT3 PMC5763493__F3 Deubiquitylation and regulation of the immune response BCL10 BCR CYLD LYN SYK TRAF2 PMC3783933__F1 IIS/TOR signaling pathway in fat body and the central nervous system of Drosophila TSC2 TSC1 ALK PTEN RHEB PMC10741038__F5 PC biosynthesis in S PC PGP PSD PMC3845553__F1 IGF-1R as an anti-cancer target—trials and tribulations IGF1R IGF1 IGF2 PTEN MTOR IGF2R PMC6407710__F7 Comparison of the phosphoketolase engineered pathway with oxidative pentose phosphate pathway PPIE ME2 CS POLE APC CIT RPE PMC10218067__F7 Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo CDK2 BCL2 MTOR CCNE1 PMC4972110__F1 Oncogenic addiction versus synthetic lethality to explain GSK621-induced cytotoxicity in AML EIF2A MTOR RHEB PMC8616208__F2 Metabolic Control of Myeloid Cells in the Tumor Microenvironment COX2 AHR KEAP1 ACLY TG ARG1 STAT3 CD36 PMC3800594__F2 Schematic model of novel cytoprotective mechanisms in response to oxidative stress in Beta-thalassemic (Beta-thal) erythroid precursors HEL-S-2a ATF4 EIF2A PMC7960990__F6 Importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation TH EME1 DES CIT PMC2936065__F2 The Lrp5-dependent regulation of bone formation through inhibition of tph1 expression and 5-HT synthesis in enterochromaffin cells TPH1 HTR1B LRP5 PMC8534848__F2 Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment IDO1 SOCS3 AHR RELB SRC SPN TGFB1 PMC3545869__F7 Integration of Canonical and Noncanonical Wnt Signaling Pathways Patterns the Neuroectoderm Along the Anterior–Posterior Axis of Sea Urchin Embryos WNT1 DKK1 PMC4551213__F6 A force-sensitive signaling network involving TRPC6 and TRPM4 channels in cerebral artery smooth muscle cells PLCG1 TRPC6 SRC PMC6443256__F1 DNA sensors and related signaling pathway TBK1 CGAS TLR9 IRF7 DDX41 DHX36 IRF3 MYD88 MRE11A IL18 AIM2 IL1B MAVS IFI16 PMC8843930__F1 Toward a Better Classification System for NK-LGL Disorders MYC CCL2 MTOR IL6R STAT3 TET2 PMC11003173__F5 Metabolic pathways of glutathione and expression profile of related genes OPLAH HEL-S-64p HEL-75 PMC5538798__F10 Schematic diagram summarized as a possible mechanism of action of melamine causing tubular cell injury via CSR-mediated Ca2+signaling pathway ME1 TGFB1 BAX PMC12214129__F8 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates H6PD PTBP1 ENO1 HEL-S-87p PDK4 SLC16A3 HEL-S-162eP PMC4852795__F1 Mechanistic target of rapamycin (mTOR) signaling pathway TSC2 ULK1 TSC1 TFEB GRB10 DEPTOR IRS1 RHEB INSR PMC6468398__F1 Biogenesis and function of ribosomal RNA-derived fragments AGO1 AGO2 TIMP3 PMC8688140__F1 Mechanisms of action of ivermectin against SARS-CoV-2—an extensive review PLG KPNA1 STAT3 PMC9706722__F3 Genomic characterization of intracranial teratomas using whole genome sequencing AMER1 MXD1 NCOR1 TGFBR1 PCDHJ MYC JAG2 PORCN PPP2R1A TEAD4 PTEN MTOR CHEK2 NF1 FGFR1 MXD4 ATM SFRP1 TCF7L1 ARAF PSEN2 NTRK1 FGFR3 DCHS1 FAT2 RICTOR MAX BRCA2 STK11 PIK3CA FLT3 MGA PMC4937164__F1 Bile acid metabolism in the liver DKFZp666G145 LDLR FGF19 FGFR4 CYP7A1 PMC11670419__F2 BA regulates glucose homeostasis UCP1 FGF19 FGFR4 UCP3 FABP1 PMC11670419__F1 Primary bile acid metabolism and secondary bile acid metabolism pathways with microbially encoded enzymes CYP27A1 GCA CYP7A1 PMC7826847__F3 C-CAMs involvement in radial migration during neocortical development VLDLR CDH4 GC SRC DAB1 CDH2 CRK NECTIN3 CP NECTIN1 CRKL PMC5807065__F4 Insulin signaling and type 1 diabetes mellitus pathways RS1 SOCS2 SOCS3 IL2 TNF IRS1 FOXO1 SOCS1 PMC11911305__F2 Simplified unscaled representation of MD‐2/TLR4 complex signaling induced by extracellular LPS TBK1 CD14 TLR4 IRF7 IRAK2 TRAF3 LBP TRAF6 IRAK4 MYD88 MAP3K7IP1 TIRAP PMC3181488__F2 Signal-receiving cell—modulation of developmental signalling by intracellular trafficking EGFR LRP5 LRP6 SMO KIF16B CBL PMC5465008__F2 Crosstalk between leptin signaling, cancer stem cells, histone deacetylases and microRNA LEP HDAC3 EPCAM HDAC7 HDAC11 LEPR CD24 PMC4271569__F8 The most sensitive regulations CNTF ChAT MOG NGF GFAP NEFH PMC5249073__F4 First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms CD14 CTSK TLR9 IRF7 CD6 IRF9 GFAP TRAF3 TRAF6 IRAK4 IRF3 RAC1 MTOR TLR3 CPO PDC TLR4 LBP CD40 FADD TIRAP PMC5530465__F1 Metabolism of chemotherapeutic drugs-related gene polymorphisms RFC1 GSTM1 PMC6328967__F4 Interaction between Wnt/Beta-catenin signaling pathway and HCV core protein APC LRP5 LRP6 PMC3876077__F1 Schematic overview of the transforming growth factor (TGF)B signaling pathway SMAD4 SKI PMC5991907__F4 PARP1 regulates repair of oxidative DNA damages FEN1 PARP1 LIG1 OGG1 BRCA1 PCNA PMC3047755__F7 Proposed model for how Shh signaling pathway negatively regulates its mitogenic potential through Beta-arrestin 1 SHH SMO IRS1 PMC5991907__F3 PARP1 contributes to regulation of redox-related signaling pathways IKBKB PIK3R1 BAD NGFR RAC1 MYD88 MCL1 MTOR MAP2K6 SGK1 TF PMC5567665__F1 Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans HEL-S-26 ACO2 HEL60 HEL-S-32 MDH2 PMC4647060__F2 Schematic of CLCA1-driven MCM in human airways based on the current literature MAPK13 CLCA1 PMC3200456__F1 Toxoplasma gondii effectors are master regulators of the inflammatory response IL1B IFNG PMC11088914__F3 The interaction of the lipid pathway with other signaling pathways for the regulation of pluripotency TCF3 SOX2 NODAL SMAD2 IGF2 FGF2 TBX3 APC MYC SMAD4 BMP4 FRS2 GRB2 PKD1 SMAD1 DKFZp781O1323 PMC3634439__F3 StarD7 in various cellular events in JEG-3 cells PC ABCG2 STARD7 PMC3625859__F3 Regulation of angiogenesis by microRNAs (miRNAs) SUFU HGS MYC SPRED1 PMC2996236__F5 Pathogenesis of the complement-mediated autoinflammatory disease atypical hemolytic uremic syndrome CFB CFI PMC7569567__F8 Kinase inhibition in autoimmunity and inflammation BCR RELA TRAF3 LTB RELB CD40 TRAF2 PMC10537735__F10 Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NFKB Signaling Pathway CTSK NFATC1 PMC11961428__F4 Proposed inflammatory mechanisms hypothesized to underlie HACE NLRP3 GDNF AQP4 PMC6031075__F1 Putative model of the functions of HSPGs in CRC cells SYN2 PMC7813945__F4 JAs biosynthetic pathway and JAs signal transduction network PMC10744266__F1 Action of warfarin relevant to pharmacogene identification (further details provided in the Data Supplement) GGCX VIT EPHX1 CALU CYP2A6 VKORC1 NQO1 CYP2C9 CYP4F2 CYP3A4 ORM2 CYP1A1 ABCB1 APOE PMC10910842__F2 Roles of the kinesin-2, 3, 4 family members in HCC KIF1B KIF3B PMC4611285__F1 AKT and ERK signaling pathway STAT1 BAD MDM2 PMC11961428__F2 Transcriptional regulation of HIF induced by hypoxia, adapted from (3) EPO VHL BNIP3L PMC8612621__F3 Crosstalk Between Parkinson's Disease and Energy Metabolism BCL2 KIN UCP2 BAX PMC2996236__F2 Autoinflammatory disease regulated by IL-1B (inflammasomopathies) and NFKB NLRP3 IL16 NLRP12 NLRP7 IL1B PSTPIP1 PMC7906938__F2 Immunological Mechanisms Underlying Sterile Inflammation in the Pathogenesis of Atherosclerosis: Potential Sites for Intervention NLRP3 HMGB1 TLR4 IRAK1 S100A12 MYD88 IL1B CD36 PMC4659514__F1 Proteins implicated in Parkinson’s disease (PD) maintain a healthy pool of mitochondria PINK1 LRRK2 PMC11722372__F2 The putative biosynthetic pathway of DAs in Aconitum plants MVD MVK IPP MVP PMC10875894__F8 VNP-shCCDC25 blocking CCDC25-NET-DNA and remodeling immunity in B16F10-bearing mice and 4T1-bearing mice HEL-S-28 MIP CD80 RAC1 CCDC25 CDC42 PARVB PMC10910842__F3 Roles of the kinesin-5, 6 family members in HCC KIF23 FOXM1 PAK6 KIF20A LIN9 KIF11 PMC7049408__F1 AMPK signaling pathway: schematic model depicts the main upstream regulators and downstream effectors of AMPK EEF2K EEF2 PMC10910842__F5 Roles of the kinesin-12, 13, 14 family members in HCC TSC2 TSC1 MMP2 TWIST1 KIFC1 TBC1D7 KIF15 KIFC3 PHGDH TCF4 STAT3 PMC7197434__F2 Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases ELF2 ATF4 XBP1 PMC2887678__F1 Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells ALG11 ALG2 ALG3 ALG8 ALG13 ALG6 ALG10 DPM2 PMC5788151__F6 Illustrating diagram for several growth factors and signaling molecules that regulate different stages of satellite cells HGF MYF5 PAX7 PMC10486640__F8 Identification of the expression of key genes of the TLR signaling pathway CD14 TLR5 F10 STAC CTSK TLR9 IRF7 MYC TRAF6 IRF3 MYD88 TLR3 TLR7 TLR4 LBP CD40 CD80 FADD TIRAP PMC7923093__F5 Regulatory pathway of differently expressed miRNAs TMEM30A MLPH CHRNA7 RNF185 MEX3C CREBL2 DHX15 CACNB4 CYP7A1 TGOLN2 HEL-S-298 POLE3 XYLB SAA4 VAPB CLIC3 MKRN2 NDRG3 WIPF1 SLC22A5 MRPL40 HEL-S-125m CASP3 RAP1A HORMAD2 GRID2 IGFBP4 TRPV5 LRRC18 GHRHR EBF2 XKRX ABCE1 PPP1R2 SRGN TMEM178A OTUD5 ACTR3 NAA11 PRSS54 PMC8836259__F10 Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression MMP10 TNLG1B CXCL1 RSAD2 MMP9 BST2 CXCL10 LGALS9 CCL5 MMP3 ISG15 IL18 TNFSF10 IL33 PSMB9 GBP4 IL1B CXCL11 ASL IFIT1 PMC5787431__F2 KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis SKOR2 P2RX2 PCDH15 HYDIN EGF SDK1 CFAP54 DPYSL4 P2RX7 GRK1 MYO16 EGFL7 RHO ZNF521 IL12A SOX17 DMD SERPINC1 HOXB4 KIF6 RIMS1 GPC1 CAMK4 NHLH2 LILRB2 TEX15 RLN1 ADAMTS2 DOCK1 CLEC11A DLX1 SIX4 AMIGO3 RBP3 KLF4 GPR65 CDKL3 PMC7663396__F1 Signaling pathways leading to signal transducer and activator of transcription 3 (STAT3) activation EGFR SRC JAK1 MTOR PMC9572668__F3 Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review NLRP3 GHSR TLR4 IL1B PMC7569567__F2 Kinase inhibition in autoimmunity and inflammation EPO STAT2 LIF IL24 TPO TSLP IFNG STAT1 STAT4 TYK2 JAK3 OSM STAT3 PMC6625878__F1 Schematic figure summarizing the HIF pathway and the transcriptional regulation by HIF of genes related to angiogenesis, metabolism, survival/proliferation, metastasis, stemness, and the ECM EPO HEL-S-30 IGF2 VEGFA VHL CD44 PFKL CCNG2 HEL-S-68p ANGPT1 FGF3 CXCR4 NOTCH1 ABCG2 TGFA HEL-S-133P ADM PMC2921023__F7 Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin GAB2 SRC MTOR PMC7234907__F1 MET receptor tyrosine kinase engages intracellular molecular signaling pathways and controls neuronal morphological development LIMK1 HGF HTT RAC1 MTOR CDC42 PMC3193404__F1 NFKB signaling pathways initiated by TLR4, TCR, TNF receptor 1, CD40 and genotoxic stress TLR4 ATM CD40 CRIPT TRAF2 PMC10608541__F13 Pathways and localization of astaxanthin biosynthesis and esterification in Haematococcus algae DGAT1 DGAT2 IPP PMC9651967__F7 Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer EIF5B PRKCE PRKCZ FOXO3A RASGRF2 ARHGEF12 MAPK7 MAPK3 KTN1 ARHA RAC1 MYO9B STK24 TRIP10 PAK1 PKP3 MAPK1 DOCK2 KRT1 SGK1 KRT10 CDC42 PMC7501262__F4 NLRP3 inflammasome in endothelial dysfunction NLRP3 HMGB1 VCAM1 IRAK1 TRAF6 IL1R1 IRAK4 MYD88 IL1B PMC3772111__F4 Computational models of the JAK1/2-STAT1 signaling STAT1 IRF-1 SOCS1 PMC6204425__F3 Some regulator genes in the eu-/pheomelanin synthesis metabolism KL KIT POMC SLC45A2 ASIP DCT PAX3 OCA2 TF PMC4024346__F1 The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras MAP3K1 BAD FOS GRB2 RAF1 JUNB PMC11594976__F7 Differential expression of hormone signaling pathway genes in PhARF5- and PhARF19a-silenced petunias BAK1 BIN2 EBF2 TF PMC6831866__F20 Continuation of the processes described in A CASP3 CASP9 LPO BAX PMC7501262__F5 NLRP3 inflammasome in endothelial dysfunction NLRP3 PMC11055549__F3 Construction of the prognostic target-ingredient network CCNA2 PLK1 TTK ATP1A1 CA9 AURKA AURKB TK1 KIF11 PPP1CC CCNB2 CCNB1 CDK4 CDC2 PRKDC HEL107 PNP CCNE2 PMC11760113__F1 Metabolism of glutamine between normal cells and cancer cells SLC7A5 SLC25A18 GOT2 GPT2 SLC7A11 GLS2 GLUD1 SLC38A1 PMC2738707__F1 Regulatory pathways in hepcidin expression USF1 HAMP USF2 EBP TMPRSS6 STAT3 PMC4196943__F5 Dissecting the Transcriptional Response to Elicitors in Vitis vinifera Cells VIT CS STS PMC7489940__F5 PI3K-AKT signing pathway MYB CHUK BAD PHLPP2 CSF3 GSK3B CSF3R MYC PTEN MTOR RPTOR PRKCA TNFSF6 STS MDM2 CASP9 RPS6 EIF4B RBL2 CD19 FOXO3A CDC37 EIF4E HRAS CREB3 DDIT4 RHEB RXRA TSC2 YWHAQ CDK2 PKN3 GRB2 PIK3CA BCL2 SYK CRTC2 PMC7363530__F1 Genetic pathways in nonalcoholic fatty liver disease (NAFLD) PNPLA3 TM6SF2 GCKR APOB ABHD5 HSD17B13 TG MTTP PMC6627586__F1 Scheme of copper and silver distribution in a mammalian cell SLC25A3 ATP7B COX17 ATP7A ATOX1 HEL-S-44 PMC6565468__F1 Convergence of Developmental Origins and Oncogenic Pathways in Malignant Brain Tumors EGF HGF EGFR APC MTOR OLIG2 CDK6 TET2 TET1 HEL-S-26 NF1 PC CDK2 MDM2 CDK4 CDC2 PMC6558092__F1 PD-1 signaling pathway in T cells.When engaged with a ligand, PD-1 becomes phosphorylated at its cytoplasmic tyrosine residue, leading to binding of protein tyrosine phosphatases (PTPs), such as SHP2 LCK ZAP70 BATF PMC9482157__F9 VEGFA promotes the occurrence of PLA2R-associated idiopathic membranous nephropathy by angiogenesis via the PI3K/AKT signalling pathway PML SCD ANAPC2 VEGFA BCL2L11 DDIT3 PMC3087179__F5 IL-4R Drives Dedifferentiation, Mitogenesis and Metastasis in Rhabdomyosarcoma IL13RA2 IL13RA1 PMC3851989__F2 The second module identified by iMCMC and the corresponding known pathway in the GBM data CDKN2B TSPAN31 CDK4 PMC4899284__F1 Folate-Mediated One-Carbon Metabolism MTHFD2L SHMT1 DHFR TYMS MTHFD1 HEL-S-51e MTHFD2 PMC2943518__F7 Diagram of a putative LPS-induced PTP/LITAF/TNF signaling pathway TLR4 LITAF PTP4A3 PMC4765525__F1 Wnt signaling pathway from KEGG BAMBI ROCK2 HEL-S-11 APC SOST GSK3B SMAD4 SKP1 POR RBX1 WIF1 PMC5375627__F5C Induction of glycolytic and tricarboxylic acid cycle enzymes by M-CSF and GM-CSF CS PFKFB4 MDH2 PDHA1 ACO2 OGDH SUCLG2 PFKP DLAT HEL-S-133P SDHD HK2 SDHB ENO3 HK3 SDHC ENO1 DLD PFKL HEL-S-87p IDH3B HEL-S-68p HEL-S-49 PFKFB2 ENO2 PMC6328967__F5 Interaction between COX-2 signaling pathway and HCV core protein NOX4 PMC7730176__F3 Estrogen and anti-estrogen signaling in glioblastoma MTOR TF STAT3 PMC11849288__F4 Expression profiles of genes in starch and sucrose metabolism pathway MYB FRK STS FOS PMC3323875__F3 Feedback inhibition mediated by the PI3K/AKT/mTOR pathway TSC2 TSC1 IGF1R ERBB3 GRB2 INS GRB10 IRS1 RHEB PMC4967146__F1 Regulation of mRNA translation initiation by the mechanistic target of rapamycin complex 1(mTORC1) signaling pathway ELF2 TSC2 TSC1 IGF1 EIF4E RPS6 RHEB PMC6678402__F2 Illustration of proposed mechanisms of stem cell therapy in rescuing ischemia-reperfusion induced acute kidney injury MAF TEC TNF ELL PMC4899284__F2 The de novo thymidylate synthesis pathway as a nuclear multienzyme complex at sites of DNA replication DHFR TYMS MTHFD1 PMC7108857__F10 Working model of FMDV 3A regulation of the G3BP1-mediated RLH signaling pathway TBK1 TRAF6 IRF3 LRRC25 PMC9450830__F4 Human arginase 1, a Jack of all trades? IGF1 ASS1 PMC9981633__F1 Targeting matrix metalloproteases in diabetic wound healing CXCL16 CXCL10 CXCL9 NOTCH1 CD80 CXCL12 PMC11274428__F1 The PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma TSC2 TSC1 MDM2 PTEN HIF1A MTOR DEPTOR MLST8 PMC3466369__F1 Emerging Roles for Cholesterol and Lipoproteins in Lung Disease TLR4 ABCG1 LDLR ABCA1 PMC6715851__F2 Differences in the carbon flux distribution in oleaginous rhodococci under nitrogen-rich and nitrogen-poor (TAG accumulation) conditions NONO CRP PMC7603577__F11 AGE-RAGE signaling pathway in diabetic complications in the treatment of gout and hyperuricemia with plantain IL6 BAX PMC7603577__F10 TNF signaling pathway in the treatment of gout and hyperuricemia with plantain LTA TRADD TRAF5 MMP9 IL6 TNF MAP3K7IP1 TRAF2 FADD TAB3 PMC3322159__F8 JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells CCNB1 HK2 PMC3713637__F4 Transcriptional regulation network centered on SP1 involves many genes of interest from pathways enriched in memory impairment PLCB3 MAPK3 ACTN2 CREB1 RAC1 ITGB1 PLCB1 CALM1 PLCB2 FYN CAMK4 SP1 APOE PMC6137035__F7 Pathway schematic VHL CA9 HIF1A STAT3 PMC11670419__F3 FXR signaling in diabetic nephropathy CPT1A DNM3 TG PMC6114234__F1 Synthesis, metabolism and anticancer mechanism of vitamin D CYP27A1 NR1i1 COX1 HEL-S-11 DBP CYP24A1 MTOR CYP27B1 PMC7430807__F2 Metabocentric view of cardiac remodeling CITED4 MTOR CEBPB PMC1800873__F1 Progression pathway network with w = 0.8, E = 0.8 and the LH algorithm GPC3 CDKN2A PMC7565554__F4 mTORC1 inhibits various steps of autophagy ULK1 TFEB AMBRA1 NRBF2 ATG101 UVRAG ATG14 PMC5374322__F3 Relationships among miRNAs and canonical Wnt signaling, metastasis, and tumor-initiating cells HMGA2 NUMB IGF2BP1 GSK3B LRP5 LRP6 TCF7L2 ASCL2 GPR49 PMC5374322__F2 Genes frequently mutated in colorectal cancer and their relationships with miRNAs LIN28B MYC TGFBR2 SMAD4 PTEN PMC7565554__F2 Transcription factors downstream of TORC1, input linked to their action and cellular processes affected TFEB ATF4 MTOR DEPTOR MLST8 PMC5374322__F1 Step-wise tumorigenesis in colorectal cancer BRAF APC TGFBR2 SMAD4 PIK3CA PTEN PMC3565105__F1 Hypothetical model illustrates the E2-ERA signaling pathway involving both genomic and extranuclear signaling pathways PELP1 GSK3B SRC POLL POLI PMC7565554__F1 TORC1 and TORC2 subunits and processes controlled by the complexes RICTOR PRR5 MTOR DEPTOR MLST8 PMC4831796__F7 Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF GPNMB PMC3233666__F1 Adaptation of endothelial cells to inflammatory stimuli and hypoxia TLR4 VCAM1 CXCR4 TRAF3 VHL RELB HIF1A PMC8006752__F1 BAP1 nuclear and cytoplasmic physiologic activities ASXL3 SLC7A11 BARD1 FOXK1 MCU BRCA1 INO80 ASXL2 OGT ASXL1 RAD51 FOXK2 BAP1 PMC9023792__F1 Emerging Role of Hedgehog Signaling in Viral Infections SUFU EVC2 PTCH1 GLI3 MYC BCL2 SMO ADRBK1 PMC10864729__F6 Predicted downstream pathway of MIR17HG ITGA1 MDM2 IPO11 PMC9023792__F2 Emerging Role of Hedgehog Signaling in Viral Infections PTCH1 GLI3 EVC SMO PMC8014416__F6 KEGG pathway analysis on three up-regulated DEGs THSD4 SMAD4 SKP1 PTEN RAC1 RGMB TNF MTOR RXRA IFNG BCR RBL2 CD19 PMC6205963__F1 Fibroblast of Growth Factor (FGF) signaling activation and regulation FGF21 FGF4 c-fgr FGF2 FGF6 FGF8 FGF18 FGF12 FGF17 FGF20 HES1 FGF23 FRS2 GAB2 FGF3 SH3BP4 FGF10 GRB2 SHH FGF14 FGF22 FGF7 PMC2780838__F1 The complement cascade HEL-S-62p C9 C4B_2 MASP1 C7 C6 C1S C4A CR1 PMC7658718__F7 Schematic model illustatrating the redox regulation of PD-L1 expression through growth factor signaling EGF FGFR1 EGFR PMC3536347__F2 Pharamcologic activators and enhancers of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) APC SOST LRP5 LRP6 DKK1 PMC3536347__F1 Pharmacologic inhibitors of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) SFRP4 APC GSK3B LRP5 FZD7 LRP6 TNKS FZD8 PMC6445295__F1 Analysis of human inner ear transcriptome over-layed on a generic human neurotrophin signaling pathway GRB2 PMC2819352__F6 Relationship of GPAT4 to other enzymes in the pathway of de novo glycerolipid synthesis HMFN0839 GPAT4 PC GPAT2 LPA PMC6595574__F2 Signaling pathway and inhibitors of inflammasomes NLRP3 BRCC3 IL1B PMC5378756__F1 The activation, amplification and regulation of the complement system HEL-S-62p FHL1 FH CP PMC2863215__F2 Regulation of mTORC signaling networks TSC2 EGF MAP4K3 EGFR RALA MTOR DEPTOR IRS1 RHEB PMC8779519__F3 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis HAL TRADD TRAF3 LCN2 POLL FADD ELL IFNG POLI PMC8779519__F2 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis EPOR CCR2 EPO RELT TPO IL17RB IL17RC CXCR6 OSMR CCL13 CNTFR CCR7 CCL19 CSF2 CCL8 LTB IL8RB TNF IL23R TSLP IL10RB EDAR LEP CD27 IFNK CXCR4 IL27RA MPL CCR3 CCR6 IL11 IFNGR2 CXCL16 IL20RA NGFR CXCL17 LEPR IL10 IL13 IL6 TNLG7C CNTF CXCR3 LTA IL27 CD40 CCL23 OSM CCL3 PMC3296254__F5 Arginine metabolic network ARG2 ARG1 CPA2 CPA1 PMC5432965__F2 Microarray profiling of 467 human GBMs discovered that polo-like kinase 1 (PLK1) was highly expressed in these tumors and that it clustered with the proliferative subtype CDC20 POLE SMC3 APC SLK PMC8779519__F4 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis GFAP POR PMC3943829__F1 A scheme of metabolic pathway for cholesterol biogenesis DHCR7 EBP MVK TM7SF2 PMC8814461__F2 Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer PIK3R1 POLD4 SOX2 FOXM1 BMI1 PTEN MTOR BRCA1 SOX9 HMGA2 BCL2 STAT3 BAX PMC5920642__F3 Cell proliferation and negative apoptosis regulation in the uterine leiomyoma HEL-S-102 HEL-S-89n HEL-S-269 HEL-S-99n BCL2 MAPK1 VCP PMC9331212__F1 Precision Medicine Highlights Dysregulation of the CDK4/6 Cell Cycle Regulatory Pathway in Pediatric, Adolescents and Young Adult Sarcomas CDK2 CCND1 CDK4 MTOR CCND3 CDK6 CCND2 CCNE2 PMC8740161__F3 Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells RFC2 POLD2 POLE CDC6 HEL-S-11 ORC1L CDT1 MON2 ORC3 PCNA ORC2 RFC4 PMC12197700__F2 Disruption of the SA signaling pathway by viral proteins SUMO3 NPR3 PMC12197700__F1 Signal transduction in the SA signaling pathway SUMO3 NPR3 PMC6143874__F2 Binding of growth factors and hormones to their respective receptors or ligands serves a pivotal role in Beta-cell proliferation TH PDX1 IGF1 CDK2 CRTC2 EZH2 RAB43 TGFB1 FOXO1 PMC7814174__F3 GDF15 and FGF21 as mitokines in the diurnal regulation of energy balance FGF21 GDF15 NTS ARC PMC6143874__F1 Binding of PDGF, GLP-1, IGF-1 and BTC to their respective receptors serves an important role in Beta-cell proliferation PDX1 IGF1R APC TCF7L2 FOXO1 RHEB CCND2 TSC2 TSC1 IGF1 BTC ERBB2 MDM2 CCND1 CDK4 EZH2 PMC6143874__F3 JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of Beta-cells EPO FOXM1 CCND1 CDK4 CCND3 PRL CCND2 PMC6230558__F6 TRPV4 activation caused oligodendrocyte apoptosis and demyelination TRPV4 HEL-S-11 IL1B CPZ PMC8669714__F3 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics ULK1 ATG12 BIK ATG101 MTOR DKFZp686F0183 PMC5159445__F2 MetaCore Immune response_IL-17 signaling pathway IL17F CCL20 TRAF6 CCL7 CCL2 SP1 IL17RC PMC7464784__F2 Illustrating the metabolic components contributing to drug resistance and drugs to overcome the resistance PIM2 EGFR FGFR4 MYD88 HIF1A MTOR HSF1 TLR4 FRS2 EN1 HEL-S-133P HK2 HEL-S-281 PMC7464784__F1 An illustration of glucose metabolism leading from the glycolytic pathway to the tricarboxylic acid cycle (TCA) and electron transport chain (ETC) VIT F2 ATR HEL-S-133P HEL-S-162eP PMC9286619__F1 The androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments EGFR SRC PMC8442523__F2 TRPV1 in the pain pathway: similarities and differences between desensitization by agonists and blockade by antagonists NGF TRPV1 ITCH PMC6064203__F4 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer CKS1B CCNA2 COPB2 POLE BUB1B PRDX3 ESPL1 SLC5A3 LSM3 PMC6064203__F3 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer RPLP2 TNFRSF25 BTD NME2 PEG3 PMC8064071__F3 Scheme of the central carbon metabolism and carotenogenesis in C HEL107 IPP RPE PMC6022934__F8 Urea cycle and pyrimidine de novo biosynthesis pathway OTC CAD DHODH NAGS CP PMC4309523__F5 An example from dGCspALL2 CCR2 MS4A1 CTSS POU2AF1 TYROBP BTK LCK CCR7 IL7R HEL-S-66 IRF4 PTPRCAP ARHGDIB PMC2315681__F8 Leptin's roles in the endocardial cushion MMP14 MMP2 PMC3181269__F1 Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis and Signaling HMFN0839 DGAT1 GPAT4 PC GPAT2 DGAT2 AGPAT3 LPA MGAT1 MGAT2 PMC2762943__F1 Epidermal growth factor receptor (EGFR) pathway EGF EGFR GRB2 PTEN TGFA PMC11635611__F3 Crosstalk among microglia and astrocytes with neurons CXCR3 NLRP3 CXCL10 BDNF PMC2762943__F3 P53 pathway MYC MDM2 CCND1 BAX PMC11635611__F2 Morphine tolerance-related signaling pathways inside microglia NLRP3 TLR4 EGFR BDNF PMC5323371__F3 Utilizing a combination of immunoprecipitation (IP) and tandem mass spectrometry (MS) protein identification (ID), complemented by gene expression analysis, a comprehensive Ang-(1-7) stimulated Mas1 receptor signaling pathway was generated MAS1 NOTCH4 NFATC4 GRIP1 NFATC1 RHO FLT3 MTOR PRKD1 CDC42 PMC8669714__F2 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics ULK1 ATG12 ATG101 ATG10 MTOR ATG14 DKFZp686F0183 PMC7261637__F8 Model depicts the proposed role of HPSE in promoting stemness SOX2 HEL-S-53e HPSE PMC8669714__F1 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics RIPK1 TRADD APAF1 BIK TRAF1 RIPK3 TNF FADD MLKL PMC2668954__F4 Mechanotransduction gone awry EGR1 RHO GATA4 PMC3797199__F1 Aryl Hydrocarbon Receptor Promotes RORGt+ ILCs and Controls Intestinal Immunity and Inflammation NOTCH2 KIT AHR IL1B LTBR PMC5650460__F1 Dual roles of yes-associated protein (YAP) in colorectal cancer EGFR SHH MTOR PMC2849843__F2 Schematic presentation of Akt-mTOR signaling TSC2 RICTOR TSC1 MTOR RHEB PMC8063392__F5 LCK pathway regulates cisplatin resistance in endometrioid tumors. Downstream of CD55, LCK stimulates expression of DNA repair genes, leading to cisplatin resistance LCK ROR2 CD55 PMC2849843__F1 Schematic presentation of PI3K-Akt signaling TSC2 BAD TSC1 PDK2 MDM2 PTEN PAX8 PMC11634819__F8 Schematic diagram illustrating the signaling pathway through which A‐MG influences hypertension, hypertension‐associated vascular remodeling, and changes in uric acid levels HEL-S-14 ACE2 PMC7701524__F10 Schematic illustration of the potential molecular mechanism of miR‐148a‐3p as a tumour suppressor in PC WNT1 CCND1 PMC7904608__F2 Metabolic regulation of trained immunity in HSCs HK3 HEL-S-30 ABCA1 PFKP HMGCR PMC7564431__F6 STRING protein interaction network of 61 out of 652 genes targeted by the selected miRNAs and directly involved in the breast cancer KEGG pathway (hsa05224) IGF1R FZD3 BRAF EGFR GSK3B MYC WNT9A PTEN RB1 NOTCH3 E2F3 CDK6 FGF9 FGFR1 WNT8B FZD2 NOTCH1 CCND1 CDK4 ARAF JUN WNT7B BAX NOTCH2 SOS2 FOS FGF2 APC TCF7L2 GADD45A DDB2 HRAS PIK3R3 DVL3 FZD5 RPS6KB1 WNT3A CDKN1A ERBB2 RPS6KB2 GRB2 PIK3CA RAF1 AKT3 FZD8 PMC3722958__F2 The suggested interplay between natural killer (NK), CD4+ T, B cells, and polymorphonuclear cells (PMN) during pemphigus pathogenesis MAPKAPK2 DSG3 MAPKAPK3 PMC3722958__F1 P38 MAPK in the induction of pemphigus vulgaris (PV) MAPKAPK2 DSG1 DSG3 MAPKAPK3 PMC9047385__F1 Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease CD14 TLR4 LBP TRAF6 IRAK4 MYD88 PMC6073671__F1 Silver nanoparticles on the cell stress response pathways ATF4 BCL2 PTEN XBP1 PMC2957893__F3 Genes in one pathway have complex “net” interactions, which should be taken into consideration when analyzing proteomics/genomic data ATM MDM2 CDK4 CDC2 PCNA CDK6 PMC5190062__F8 ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis ATF4 RAD51 PMC7680862__F1 Mitochondria-associated ER membranes and cell physiology NLRP3 PML VAPB MFF GPR75 TXNIP MCU PTEN MTOR FIS1 OPA1 PMC6803036__F2 Secreted IgM: New Tricks for an Old Molecule HEL-S-62p PC BCR PREB GC ELL PMC2866141__F4 Molecular Basis of Pulmonary Alveolar Proteinosis CD14 IRAK1 TRAF6 MYD88 TIRAP MAL PMC9168125__F1 Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy? TWIST2 CD7 SP1 PMC6144927__F1 TGFB signaling maintains homeostasis between the proliferation and apoptosis of normal epithelial cells by Smads or other Smad-independent downstream pathways SMAD2 MMP9 MYC SMAD4 PMC8904278__F3 Metabolic Rewiring by NRF2 GCLM GPX4 GCLC PSAT1 SLC7A11 HEL-S-64p HEL-S-304 PSPH SLC3A2 HEL107 PHGDH PMC6017900__F7 Signaling pathways for flaccidoxide-13-acetate in bladder cancer MMP2 GRB2 ARHA MTOR PMC8754418__F1 Congenital Micropenis: Etiology And Management SP1 DKK2 PMC4905404__F2 Regulators of phenotypic plasticity HGF CD44 ABCG2 PMC10789540__F5 IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma IFITM3 IRAK1 TRAF6 PMC2880413__F2 Networks for (A) Biological network (B) Network MDL approach (C) PMDL approach The performance on the algorithms is performed on a biological data set CDC20 SMC3 CDC27 PMC8639566__F1 Sensing Stemness CGAS IRF7 TRAF6 IRF3 MAVS PMC3874211__F4 Network pathway analysis integrated the majority of proteins identified as changed on 2DE (), as shown in but did not include S-methyl-5`thioadenosine phosphorylase, and lamin B1 because of low scoring APOA4 RBP1 NCALD PSMB2 DPYSL3 DPYSL5 PSMA2 DLD ACAT2 HEL-S-49 TUFM HNF4A PSMC6 STUB1 HTT HNRNPC HEL-S-276 RCN3 HNRNPH1 HEL-S-70p VCP LRPAP1 TGFB1 GLS PMC4979452__F7 Cell adhesion NCAM2 GFAP CD44 NRCAM PTEN CRK FER MCAM PLAT PAK1 FYN TIMP1 JAM2 TRIO PMC7805339__F1 Current understanding of the mechanism of action of luspatercept SMAD2 GDF1 GDF10 GDF11 PS1TP5BP1 GDF3 PMC4979452__F6 Protein kinase A (PKA) signaling pathway RGS4 RASA2 BDKRB1 AGTR2 PYGM GHRH EDNRA RAP1A DDC GNRH2 MDM2 BDKRB2 HTR2A PMC3820535__F7 Modeling Integrated Cellular Machinery Using Hybrid Petri-Boolean Networks MAX TF CDC42 GPD1 PMC4979452__F8 Cytoskeleton remodeling and axonal transport MARCKS ARHGEF1 GFAP NEF3 NEFH RAC1 SLIT2 HRAS CXCR4 FARP2 DCTN1 HEL-S-77 SRGAP2 LINGO1 APOE NTNG2 CDC42 OPA1 PMC1894940__F5 Inhibition of COX-2 modulates multiple functional pathways during acute inflammation and pain ALOX15B ALOXE3 HPGD SOCS3 IL6 ALOX12B PMC3296254__F7 Lysine biosynthetic pathway HEL-S-26 MKS1 PMC4979452__F3 Ion homeostasis NOG CALHM2 SNAP29 FXYD2 CFTR PMC9355504__F1 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer SRRM4 TWIST2 SOX2 SPINK1 IGF2 IL8RB REST MTOR TGFA STAT3 FOXA2 PMC4979452__F2 Mitogen-activated protein kinase (MAPK) signaling pathway EGF BAD EGFR MAPK3 RASA2 ATF1 MAP2K3 RASA3 FGFR2 NCK1 ETS2 SP1 MAPKAPK2 GRB14 ARHGEF1 SOS2 FGF2 ATF3 MAP2K2 GRB7 RET RAP1A GRB2 FLT3 GRB10 SOS1 TRAF2 SP3 PMC6678596__F1 Representation of the main DNA repair pathways involved in platinum salts-induced DNA damage PALB2 ATM BRCA2 SSB RAD51 ATR BRCA1 PMC5560156__F1 Schematic overview of the molecular network involved in VSV oncoselectivity TBK1 LDLR IRF3 PTEN MTOR PMC4979452__F5 JAK-STAT (Janus kinase/signal transducers and activators of transcription) pathway CCR5 EGF CS EGFR AGTR2 IFNG STAT1 ERBB2 IL2 NMI OSM TGFA FANCE STAT3 PMC4979452__F4 PI3K-AKT (phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT) signaling pathway ARHGEF1 IGF1R TRADD NGFR IGF2 EGFR APIP PTEN TNF FGFR2 PMC3539919__F2 Simplified carbon metabolic network HEL-S-49 ENO2 HEL-S-32 HEL-S-68p PMC6032252__F1 The tumor microenvironment on myeloid cell differentiation and metabolism TBK1 HGF LIF CD80 S100A9 PMC12103044__F10 Examples of eExo for promoting chronic wound healing TLR4 PTEN MTOR SIRT1 HIF1AN STAT3 SIRT3 PMC8349099__F1 Calcium signaling in hepatitis B virus infection and its potential as a therapeutic target CASP3 SRC BCL2 MCU VDAC3 ORAI1 STIM1 CD36 PMC3048914__F6 Differentially expressed genes in the MICs as compared to NSPCs SPARC FLI1 EGF HAVCR1 EGFR ETV4 PTEN CDKN2A CCNE1 CNTF IGF1 TIMP1 SP1 PMC4937866__F13 AhRR repression on AhR activity and the consequences in endpoints AHRR AHR TF PMC6563055__F4 NOX4-related mechanisms in thyroid carcinogenesis NOX4 TF PMC3668263__F3 Wnt signaling pathways DAAM1 APC RHO CDC42 PMC3668263__F2 LRRK2 regulates cell biological functions important for neurogenesis LRRK2 APC LRP5 LRP6 PMC3986808__F2 Copper is passed (green arrows) to cuproproteins (dark green circles), including metallothioneins Crs5 and Cup1, in for example Saccharomyces cerevisiae, by copper metallochaperones (pale green circles, or ovals if membrane associated) COX2 COX1 COX17 SCO1 HEL-S-44 COX11 CCS PMC6301151__F8 Schematic graphic of the mechanism underlying chondrogenesis driven by PC nanofiber membranes PC VCAM1 TRAF1 MSC LTB ACAN COL2A1 TNF SOX9 PMC2377014__F10 BDNF enhancement of glutamate-induced phase shifting in the SCN, and potential locations in the signaling pathway where ethanol could inhibit this process GC SRC BDNF PMC9577160__F2 Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review RUNX3 TSHR SI TIMP3 CDK4 PTEN PMC9146702__F1 An Insight into the Novel Immunotherapy and Targeted Therapeutic Strategies for Hepatocellular Carcinoma and Cholangiocarcinoma TYK2 FLT3 MTOR PMC6883840__F10 Proteins and metabolites in JK1 that change by >2-fold relative to wild-type E RPIA RPE HEL-S-162eP PMC6947886__F3 Differentially expressed genes in the estrogen signaling pathway HEL-S-11 BCL2 POR TF PMC3233269__F1 PA can be generated de novo,, by sequential enzyme-catalyzed acylations of glycerol-3-phosphate, or in response to cell signaling pathways () PC PTEN LPA LPP MTOR HEL-S-5 PMC9414909__F4 Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy LPO BAX PMC6757285__F1 Glutamine-dependent regulation of BMSC osteogenic and adipocyte differentiation GOLPH2 MTOR GLS PMC5386675__F3 Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin BLM SMPD2 SNRPA APTX CHEK2 ERCC5 PC4 OGDH TIA1 SRCAP TIAL1 CHL1 ATXN3 XPC RCC2 DDB2 RPL15 CHEK1 RAD18 CCNB2 MAEA MLLT3 HLTF PIAS1 FANCM ERCC1 XPA ERCC2 SOS1 GALK2 ATR PMC4997401__F5 Promoter-specific DNA methylation of genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) mitogen-activated protein kinase (MAPK) signaling pathway CD14 NLK MAX FLNA GRB2 TRAF6 ECSIT RAF1 MEF2C PMC11648684__F8 M6A on apoptosis YTHDF1 METTL3 MYC MCU PTEN IGF2BP2 BAX PMC8989557__F2 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy STAT1 STAT2 HEL-S-92n CTLA4 JAK1 STAT3 PMC8989557__F1 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy CD40 PMC9239699__F3 ERH Interacts With EIF2A and Regulates the EIF2A/ATF4/CHOP Pathway in Bladder Cancer Cells RPLP0 RPS4X FBL RPL7A HAL PTBP1 CHTOP RPS9 HEL-S-130P RPL31 RPL29 RPL23 RPL10 RAN RBM22 RPL27A TARDBP PMC8551388__F3 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica KEAP1 APP IL1B PMC3233269__F9 G protein-coupled receptors (GPCR) trigger dissociation of GA and GBG heterotrimeric G proteins upon agonist stimulation PC ARHA RHO LPA LPP GAA PMC6446704__F2 Regulation of FABP4/aP2 secretion from adipocytes TG HEL-S-104 PMC3227953__F1 PI3K/Akt/mTOR pathway signaling in tumor and vascular endothelial cells VHL OTOR PMC5735818__F1 Schematic overview of the TEK signaling pathway which was built with CellDesigner 4.4 RET MYC SHE PTEN OTP PMC5133984__F6 Schematic diagram showing the signaling pathways leading to METH- and gp120-induced autophagy MTOR DKFZp686F0183 PMC8064670__F1 GM-CSF signaling pathways PIM1 OSM IRF4 PMC8338747__F1 ExTreg generation RUNX1 STUB1 IL33 PTEN HIF1A MTOR GATA3 CBFB STAT3 FOXP3 PMC7374866__F7 B.coccineus ethanol leaf extract induces cell cycle arrest and apoptosis via the p53 dependent pathway BAD CDK4 BAX PMC3279755__F1 Signaling pathways of the fibroblast growth factor receptor in neural stem cells GRB2 CBL PMC6296511__F3 Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study HEL-S-62p F10 PROS1 C4B_2 F2R THBD F9 PROC C4A CR1 CLU CFI SERPINC1 PLAT C9 C1QA A2M SERPIND1 F2 F3 C7 SERPING1 MASP2 SERPINA1 C1S KNG1 TFPI PLAUR PLG MASP1 BDKRB1 KLKB1 C3AR1 CPB2 C1QB F5 C8G C6 F7 CR2 SERPINF2 PMC3148577__F1 Metabolic networks of Corynebacterim glutamicum (a) and Brassica napus (b) corresponding to the experimental fluxes measured by and respectively VASP AIDA HEL114 CIT MAL PMC3148577__F3 A heterotrophic plant cells VASP CIT MAL PMC6885181__F5 HIF-1-miR-219-SMC4 axis regulates proliferation and migration of HCC under hypoxic condition CDK2 CDK4 SMC4 PMC11678862__F2 Dietary restriction on lipid profile changes and healthspan IGF1 NR1C1 FOXO1 PMC11049451__F3 Estrogen biosynthesis pathway from cholesterol to estetrol with the enzymes involved CYP3A4 CYP11A1 HSD3B2 CYP17A1 PMC11678862__F1 Molecular mechanisms linking dietary restriction to lipid metabolism and health benefits TSC2 TSC1 IGF1 PTEN RHEB CYP7A1 PMC5314358__F8 Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGFB1 VCAM1 SMAD2 SMAD6 KLF4 CXCL8 TRAF6 KLF2 CCL2 SELE TAGLN PMC10385841__F6 Top networks associated with lipid metabolism identified in PIEs infected with G5P CLSTN2 MRC1 CDON KMO PCDH7 NKX3-2 PFKFB2 ADAMTS8 PCDH18 FLRT2 MYO1F HIC1 PMC8551388__F1 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica KEAP1 APP IL1B PMC10385841__F5 Top networks associated with lipid metabolism identified in PIEs infected with G9P[13] NAAA ETV3 GALNS CCDC34 ARHGAP36 STON2 TMCO2 FAM241B TM4SF20 AHNAK SUSD6 CIDEB DFFB ANO7 FA2H B3GALT2 CLN3 PBX3 OCIAD2 ADM PMC10385841__F4 Rotavirus interactions with the host innate immune system STAT2 IRF9 IFNE IRF3 IFNAR2 IL6 IFNAR1 MX1 STAT1 OAS1 CCL28 CCL25 MAVS PMC5569936__F7 Metabolic control involved in aging and on the cardiovascular system IGF1 MTOR TGFA PMC11535070__F4 Proposed crosstalk model between TET1, WNT, mir200b, and miR494 in CRC progression ZEB2 APC BMI1 PMC8996963__F2 Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue MMP14 MMP2 LPL VWF NOX5 TF CD36 PMC11857948__F9 Selected differentially significant signaling pathways in M CXCL1 MMP9 CSF3R CXCL8 CXCL2 RAC1 MYD88 MTOR IL17RB OSMR MMP3 PIM1 COX2 TLR4 CCL20 LBP IL7R STAT3 PMC6236061__F1 PPAR signaling pathway LPL NR1C1 FABP1 ACOX1 PMC9445132__F3 Mitophagy: A potential therapeutic target for insulin resistance PINK1 ULK1 SQSTM1 FUNDC1 SRC BNIP3 PMC2655678__F1 ATM activation in response to DNA DSBs FANCD2 ATM CDK2 MDC1 MDM2 RAD50 MRE11A BRCA1 PMC9126300__F2 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease ATF4 EIF2A TRAF2 XBP1 PMC5627649__F5 Signaling and gene regulatory networks in mammalian lens development NF2 HEL-S-28 CRIM1 LRP5 LRP6 CDH2 PMC9126300__F1 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease ATF4 EIF2A TRAF2 XBP1 PMC5627649__F4 Signaling and gene regulatory networks in mammalian lens development HSF4 CRYBB1 PROX1 CRYAA PMC3959225__F5 Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome BAD IGF1 APP PMC11791135__F6 Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation MYB BAD MEI1 PROC CDC37 PTEN RAC1 BRCA1 RHEB TSC2 BCR EIF4B RBL2 CD19 PMC5752874__F3 HMGB1 receptor and possible signaling pathways SLA HMGB1 CDC42 PMC8478908__F2 TNFA/TNFR1 signaling activates necroptosis and triggers apoptosis and inflammation RIPK1 TLR4 TRADD CYLD RIPK3 TRAF2 FADD MLKL TAB3 PMC6957738__F1 ERBB and signaling effectors in PKD EGF ERBB2 GRB2 AVP SRC TPR AQP2 HBEGF PTEN TGFA CFTR PMC7202494__F7 Let-7f-5p/TARBP2 regulatory feedback loop in OS cells, which is induced by hypoxia and reduces the expression of let-7f-5p and TARBP2 in OS cells GSK3B TARBP2 PMC6751321__F9 Diagram of the signaling mechanism involved in the myocardial protection mediated by carvacrol PTEN TRPA1 TRPV3 PMC8834070__F2 Shifting the Focus of Signaling Abnormalities in Colon Cancer EGF EGFR GRB2 PMC5936719__F1 Summary of unfolded protein response ATF4 EIF2A XBP1 PMC8834070__F4 Shifting the Focus of Signaling Abnormalities in Colon Cancer CDK2 FOS MYC CCND1 CDK4 JUN CDK6 TCF4 CCNE1 PMC4872452__F2 Network analysis of blood transcripts MARCKS IRF3 STOML3 ADCY3 DGKA CMAS CD59 CDR2 AMFR IFNA16 TMUB1 GMFG GPR84 PMC2673242__F1 Loss of PTEN function results in accumulation of PIP3, which activates a cascade of signaling molecules BAD PTEN MTOR ELL PMC4381588__F1 Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma LIN28B EIF5A PMC2268054__F2 Mutations in the glycoprotein 130 (gp130) receptor lead to an imbalance in downstream signalling pathways STAT1 SOCS3 JAK1 STAT3 PMC8026307__F2 FOXO1 activity by periodontal microbiota in gingival epithelial cells NLK TRADD ZEB2 PRDX3 FOXO1 PMC2268054__F1 Role of glycoprotein 130 (gp130) downstream signalling in the heart STAT1 LIF GRB2 IL11 JAK1 OSM STAT3 PMC5655319__F1 Update on the therapeutic significance of estrogen receptor beta in malignant gliomas EGR1 CRP PTEN SP1 MTOR TSN PMC2915629__F4 Identification of RON-targeting genes TP53BP2 PRKCZ TCF3 HCFC1 FOS FGFR3 ATF3 RB1 SLC6A2 RBBP6 LMX1B HOXA11 UBC PTPRU GHR YY1 JUN PMC9107227__F7 Positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression STAT1 CXCR1 NFKB1 CXCL8 IL8RB PMC6685392__F4 Multi-loop model of AD: an integrated perspective on the Wnt/GSK3B, Alpha-synuclein, and type 3 diabetes hypotheses GSK3B DKK1 PMC10216514__F5 Ferroptosis signaling pathway GPX4 HEL-S-64p TF GLS PMC1766919__F1 Signalling footprints of the TNF/TNF-R superfamily TRADD TRAF5 TRAF2 FADD PMC6685392__F1 Dysfunctions in canonical Wnt-Signaling contribute to the neuropathology of Alzheimer disease (AD) GSK3B APP LRP6 DKK1 PMC3977149__F1 p53 effects multiple areas of cellular metabolism TIGAR SCO2 GLS2 PMC11607912__F3 Differentially expressed genes and DNA (hydroxy)methylation levels within the TRP metabolic pathway and NAD pathway KYAT3 NADK DHCR24 DLD PARP1 IDO2 PARP4 CYP2E1 SLC7A5 NAPRT HAAO HEL-S-90n CYP8B1 DHTKD1 GOT2 NMNAT2 NADSYN1 SIRT1 PNP PMC11607912__F6 Gene regulatory network (GRN) of TRP and NAD pathway PARP14 SIRT2 MAOA IDO2 CYP1A2 GCDH SIRT3 HEL-S-90n ACAT1 SIRT6 CYP1A1 OGDH ALDH1A2 NAMPT PTGIS PTGS2 HEL-S-53e DLD PARP1 CYP2E1 ACAT2 SLC7A5 IDO1 SIRT7 CYP2J2 CYP3A4 SLC3A2 SIRT1 EHHADH ALDH2 PMC7999074__F2 Activity of YAP/TAZ is influenced by various metabolic cues PFKFB4 RHO MTOR SLC38A1 HMGCR HEL-S-68p SLC7A5 PSAT1 OGT SLC1A3 PFKP HEL-S-133P HK2 PMC7999074__F1 Hippo signaling pathway comprises a cascade of phosphorylation and activation of kinases, which ultimately regulate YAP and TAZ subcellular localization NF2 VGLL4 LATS1 PMC8222692__F3 Treg: A Promising Immunotherapeutic Target in Oral Diseases APC IL33 CCR4 MTOR CCL22 FOXP3 PMC11891403__F6 Exogenous fatty acids inhibit fatty acid synthesis by competing with endogenously generated substrates for phospholipid synthesis in Escherichia coli LPA FADD HEL-S-5 PMC8704804__F1 Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension HEL-S-277 ARG2 ARG1 AGXT2 PMC4468904__F6 Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis ASMT IDO1 INMT KYNU DDC KMO AOC2 AADAT AANAT TDO2 PMC5904768__F3 DNA damage stress response in the TRIM59 network CHEK2 HIPK2 EP300 TRIP12 WEE1 ATM RPRM DKFZp781B1423 MDM2 ATR C13orf34 AURKA PMC5904768__F5 p53 signaling in the TRIM59 network CHEK2 HIPK2 EP300 ATM CDK2 TOPBP1 CDK4 ATR CCND2 PMC8129027__F1 Study of the Regulatory Mechanism of the CB1/PPARG2/PLIN1/HSL Pathway for Fat Metabolism in Cattle ACSL6 PDE3B ACSL5 FACL4 HEL-S-104 PPARG IRS1 ACSL3 SIRT1 FOXO1 PMC11768235__F1 Exosome-mediated communication between immune cells and keratinocytes contributes to the development of psoriasis OLFM4 IL36G IL24 PMC6280699__F8 Proinflammatory and anti-inflammatory effects of IFNB in CF: (A) IFNB triggers JAK/STATsignaling pathway activation (STAT1, STAT3, and STAT3 proteins) STAT1 STAT2 STAT3 PMC8509311__F1 Impact of Selenium Deficiency on Cardiovascular Function SELENOT SELENOP SELENOW SEPHS2 MSRB1 SELENOK PMC7238364__F5 PPI network analysis of the overlapping DEGs TUBA4A MYBL2 USP2 TUBB CWC27 ORC6 RELB LRP8 TDRP DHX16 KLHL2 NEDD4 NFKBIA KAT7 SRP68 SLC35B1 PSMD2 BRD2 RNF169 PSMD11 PMC8909279__F2 Nutrients against Glucocorticoid-Induced Muscle Atrophy ELF2 TSC2 SMAD2 GABARAPL1 EIF4E BNIP3 MTOR PMC7795823__F6 Proposed mechanisms for the action of ACF on melanoma cells under normoxic conditions ELF2 ATF4 PDPK1 PMC10149906__F1 Building on the backbone of CD47-based therapy in cancer: Combination strategies, mechanisms, and future perspectives SIRPA CGAS CD47 HEL-S-92n PMC11018997__F6 Multiple functions of the nonstructural protein 3D in picornavirus infection TANK IRF7 IRF9 IRF3 TYK2 IFNAR2 NOD2 MAVS PMC11046940__F3 Regulation of autophagy to affect radiosensitivity involves a complex network of signaling pathway HMGB1 ULK1 ATM SRC PTEN MTOR STAT3 PMC6122069__F1 Two major signaling axes in IGF-1-mediated EMTs in human breast, lung, and gastric cancers MUC1 DDR1 IGF1R IFITM2 IRS1 IGF1 TWIST1 ANXA2 TM4SF4 ZEB2 GRB2 SRC STAT3 PMC11046940__F2 Mechanisms by which autophagy modulation affects chemosensitivity are multifaceted and involve multiple signaling pathways ULK1 ATG16L1 ATG12 ATG3 SQSTM1 ATG101 ULK2 ATG10 DKFZp686F0183 MLST8 PMC2852400__F7 Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes BRAF MDM2 CDK4 CDKN2A PMC8306625__F1 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases PSG1 TLR4 IRAK2 DUOX2 TRAF6 NOX4 IRAK4 MYD88 TIRAP NOXA1 PMC8527034__F7 Astragalus Polysaccharide Reduces Blood Pressure, Renal Damage, and Dysfunction Through the TGFB1-ILK Pathway HEL-S-28 SMAD2 PMC8306625__F3 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases NLRP3 NLRP2 TXNIP MAVS PMC8142022__F4 Metabolism and cell signaling in ferroptosis FACL4 NF2 BAP1 PMC3989988__F1 De novo serine biosynthesis diverges from glycolysis TIGAR GLS2 PSPH PHGDH PMC8223745__F1 Current Challenges and Future Perspectives of Renal Tubular Dysfunction in Diabetic Kidney Disease STAT1 MFN1 HMGB1 TLR4 IRAK1 ATF2 IRAK4 MYD88 JAK1 KLF6 SGK1 STAT3 PMC11796622__F5 IL17RA mutation and downstream signaling pathway EBP TRAF6 IL17RC PMC7892335__F1 Loss and revival of androgen receptor signaling in advanced prostate cancer SOX2 NGF EZH2 RB1 ARSI FOXC2 AURKA PMC5697417__F2 IFITM proteins are involved in various cellular processes with direct and indirect impacts on immunity IGF1 BAG3 AMBRA1 INS SRC FITM2 IRF3 MTOR PMC5731828__F1 An emerging role for the ribosome as a nexus for post-translational modifications TCOF1 RPL13a RPS2 RPS15 RPS6 RPS3 RPS20 RPS10 PMC7281607__F1 Simpified major metabolic pathways of tryptophan (TRP) in humans KYNU KMO PMC4445995__F2 Stem cell response to matrix stiffness by integin, cytoskeleton and signal transduction crosstalk MAP2 RUNX2 NR1B3 YAP1 GRB2 ARHA GATA4 GATA2 PMC98951__F2 Signaling pathways of IFNA, IFNB, and cytoplasmic dsRNA STAT1 TYK2 JAK1 PMC4082998__F1 Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes FXYD7 EGFR SRC PMC11907956__F5 PTMs of CD47: When CD47 on the surface of tumor cells interacts with SIRPA on macrophages, it causes the intracellular portion of SIRPA to be phosphorylated SIRPA CD47 TRIM21 PMC12021826__F10 Schematic diagram illustrating how AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway during inflammatory responses TLR4 AREG EGFR MYD88 RPLP1 GSDMD PMC11907956__F4 Structure and PTMs of PD-L1 (phosphorylation, glycosylation and ubiquitination): Presented here is a schematic diagram that illustrates the functional domains of PD-L1 as well as its diverse PTMs EGF GLT1D1 USP21 ARIH1 TRIM21 GSK3B GSK3A B3GNT3 NEDD4 RNF125 CMTM6 USP9X NEK2 CDK4 SPOP JAK1 USP22 PMC4638047__F7 Pathway analysis highlights APP is a central hub interacting with nearly 40% of candidate molecules in EGS NENF ENSA MBP STXBP1 FKBP5 SNAP25 PFDN2 PARVA PFDN6 AGRN PMC6549079__F5 Signaling pathways related to RUNX3 RUNX3 SMAD4 BRD2 TCF4 PMC6549079__F4 Signaling pathways related to RUNX2 EGF RUNX2 SMAD2 ZEB2 EGFR GSK3B PTH PMC11537862__F3 Possible pathways of apoptosis inhibition by Brucella NDUFS6 NME2 DDIT3 NEDD4 HEL-S-29 SDHB PMC6549079__F3 Signaling pathways related to RUNX1 EGF RUNX1 ERBB2 EGFR GSK3B PMC11537862__F2 Brucella triggers inflammatory responses NLRP3 TXNIP MYD88 TRAF2 AIM2 NOD2 PMC11876635__F7 SEMA3F-dependent pathways MTOR NRP2 PMC11907956__F8 PTMs of TIGIT: TIGIT binds to CD112, CD113, and CD155 APC GRB2 TRAF6 TIGIT PMC4705549__F5 Multiple functional linear model for association analysis of RNA-seq with imaging NDUFS4 PROZ MRPL33 CCDC71 TMEM258 SFRS8 PMC6371002__F2 Mechanistic cross-connection between the transforming growth factor beta pathway and bone morphogenetic protein signaling BMPR2 HAMP HFE TFR2 PMC6274916__F2 Complement activation by foreign biomaterial surfaces in bone tissue, and strategies to modulate the complement system HEL-S-62p MSC CR1 CP PMC2819049__F3 Different components of shelterin are dedicated to different aspects of the end-protection problem ATM ATR PMC1389768__F1 The Challenge of Characterizing Operations in the Mechanisms Underlying Behavior C6 PMC10376170__F2 Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms ATF4 MTOR STAT3 BAX PMC6512804__F6 Fatty livers demonstrate a premalignant signature CASP3 SUFU FH APC VHL CASP9 SHH SMO RHO PTEN DCC PMC7870817__F5 GSK3Beta-Beta-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a GSK3B YY1 PMC8105434__F8 Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism NLRP3 IL1B PMC8584071__F3 Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers TWIST1 GSK3B HIF1A STAT3 PMC8215263__F1 Effect of Oxidative Stress on Diaphragm Dysfunction and Exercise Intervention in Chronic Obstructive Pulmonary Disease TNF UCP2 PMC11966298__F4 Applications of metal-based nanomaterials in tumor immunotherapy TBK1 CGAS IRF3 PMC11966298__F1 CGAS-STING pathway CGAS CXCL10 CXCL9 IRF3 TNF PMC9403721__F1 Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds ULK1 ATG12 ATG3 ATG101 ULK2 UVRAG ATG10 PMC2753670__F3 Integration of ITAM and cytokine Jak–STAT signaling STAT1 SYK TYK2 JAK1 PMC6016592__F2 The two faces of pannexins: new roles in inflammation and repair IL18 PANX1 IL1B GSDMD PMC6763828__F9 Schematic model of intracellular signal components that control S-phase entry in vestibular epithelia from neonatal mammals PI3 ERBB2 HEL-S-11 PMC2799977__F2 TLR signaling upon intrinsic cellular defenses TRAK1 TBK1 TLR9 IRAK2 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 IL1B PMC5690809__F7 Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding BRPF1 PIK3CA KAT6A TRIM24 PMC4172307__F1 Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors HEXA RELA EIF4E MTOR PMC5890159__F1 Nutrient activation of PKA in the yeast GIP RGS2 PDE12 PMC10487526__F9 Proinflammatory immune response in BV-2 microglial cells induced by NfEVs JAK1 STAT3 PMC9492833__F2 Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy VPS33A STX7 STX6 PLEKHM1 STX18 EEA1 VAMP4 STX5A BET1 USE1 VAMP2 VAMP3 SEC22B STX16 STX3A STX17 ATG14 VAMP8 BNIP1 STX8 VAMP7 SYT2 PMC5289991__F2 MYC-driven self-reinforcing loop in ESCs SOX2 MAX APC LIF GSK3B MYC LRP5 LRP6 DUSP2 DUSP7 AEBP2 PMC7283439__F7 FG-4592 activity on depression EPO HOMER1 BDNF PMC5289991__F1 MYC regulatory networks in pluripotent stem cells PRMT7 LIF MYC SFRP1 DKK1 DUSP2 HDAC1 HEL-S-133P DUSP7 AEBP2 STAT3 PMC3798916__F1 Methylation cycle HEL-S-61p PEMT PMC9403519__F9 Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/Beta-catenin/survivin signaling pathway in glioblastoma SOX2 CD44 DKFZp686F0183 PMC3185579__F3 TLR-dependent and independent IFN-I induction, signaling and action TBK1 TLR9 STAT2 IRF7 IRF9 ATF2 IRF3 MYD88 TLR3 MX1 RNASEL STAT1 ISG15 TLR7 TRIM50 ISG20 TYK2 JAK1 PMC7394593__F1 The roles played by the TCA cycle and the Warburg effect in gastrointestinal cancers and normal tissues CUEDC2 FH PFKFB4 OGDH BRD7 CGA PFKP HMGB2 HEL-S-133P HEL-S-32 PMC9646879__F7 Various biological functions of the human Rix1 scaffolding complex PELP1 TEX10 SENP3 PMC6532258__F7 Proposed model for GPAA1 promoting growth and metastasis of gastric cancer GPAA1 ERBB2 EGFR PMC8430477__F6 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway FBXL14 CXCR4 CXCL12 CDH2 MTOR NR2A2 PMC8430477__F5 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway GPX4 SLC7A11 SLC3A2 PMC3213329__F3 Ingenuity pathway analysis of phosphatidylinositol 3-kinase (PI3K) signaling pathway affected by angiotensin II BAD MDM2 PTEN EIF4E MTOR RHEB CP PMC8430477__F7 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway CXCL1 DACH1 PDCD1 FOXP3 PMC8430477__F2 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway KEAP1 VCAM1 ATF4 VEGFA SIRT1 BAX PMC8430477__F1 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway HEL-S-2a ULK1 EIF4E MTOR GPX7 SIRT3 PMC5358377__F6 Cellular localization of the autophagy genes regulated by 1,25(OH)2D3 (Ingenuity Pathway Analysis software) in MCF-7 cells HEL-S-62p ATG3 BCL2 STX17 ATG10 MTOR WDFY3 PMC4228291__F1 Wnt signaling pathway and its key components APC LRP5 LRP6 PMC8430477__F4 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway PELP1 SIRT1 BAX DFNA5 PMC8233448__F1 NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies NLRP3 IL1B PMC8430477__F3 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway RIPK1 RIPK3 MLKL PMC12241215__F3 Diagram represents various therapeutic strategies targeting AML through different molecular mechanisms CD33 MAX MDM2 SMO BAX PMC8523334__F3 TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy TRAF1 TRAF3 TRAF2 PMC9458863__F3 Current progress of ferroptosis study in ovarian cancer GPX4 FACL4 SLC7A11 EGFR FZD7 SLC3A2 MTOR SKP2 PMC1351175__F11 Proposed Receptor Ck – dependent signaling pathway involved in hTERT gene regulation at the transcriptional level APOB PC LDLR SP1 PMC11519599__F3 Signal transduction pathways in ferroptosis under HS GPX4 TLR4 FACL4 SLC7A11 TEAD4 SLC3A2 PMC7182338__F4 BCR signaling pathway and its targeted inhibition BTK BCR BASH LYN SYK CCL4 PLCG2 BCL6 CD19 CCL3 PMC4137125__F3 Schematic representation depicting deleterious effects of overnutrition and obesity in the vasculature and targets for DPP-4i TH DPP4 CAD TGFB1 IRS1 PMC11519599__F2 Signal transduction pathways of necroptosis under HS RIPK1 TRADD RIPK3 HSF1 TRAF2 FADD TLR3 ZBP1 MLKL PMC3070844__F3 Top-scoring network created by Ingenuity Pathway Analysis NPM1 HEL-S-97n ANXA2 PPP2R1A HYOU1 SERPINB2 PMC8103163__F7 Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1B/CXCL1 Signaling NLRP3 TLR4 IL1B GSDMD PMC8290830__F4 Autophagy in hepatic fibrosis ULK1 ATG12 MTOR DKFZp686F0183 PMC11934544__F7 Protective mechanism of EA on IVDD ELF2 AQP3 MAP2 MAP1B AQP1 MAP1A PMC8290830__F2 Autophagy in hepatic fibrosis HMGB1 ULK1 ATG12 ALG13 MTOR ATG9A DKFZp686F0183 PMC9471313__F3 Excessive intake of sugar: An accomplice of inflammation COX2 TLR4 LCN2 TNF IL1B PMC7586926__F1 SARS-CoV-2 pathogenesis CTSL ACE2 TMPRSS2 PMC3323898__F5 Graphical representation of the known connections between the Wnt/Beta-catenin pathway and the Notch1 signaling pathways, according to the knowledge of the current literature FHIT NUMB APC MYC NRARP HRAS NKD2 NEDD4 MMP7 LEF1 MMP14 HEY2 MDM2 NOTCH1 CCND1 SGK1 PMC4365881__F4 Extracellular regulation of satellite cell fate SDC4 FGF2 PAX7 SDC3 PMC9139349__F2 Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping MFN1 MFN2 NRF1 TFAM FIS1 TF OPA1 PMC5290970__F8 Signaling switch between hyperglycemia and normoglycemia PI3 GRB2 IRS1 PMC6656753__F5 Significant dysregulation of P53 pathway in urothelial cells exposed to either S PML MYC PIGS PTEN RFWD2 TSC2 CASP3 FER SIAH1 ATM CDK2 MDM2 CASP9 ATR BAX PMC6656753__F4 Significant dysregulation of genes involved in Colorectal Cancer Signaling Pathway in urothelial cells CASP3 EGF BAD APC CASP9 SMAD4 CCND1 MSH3 RHO MSH2 DCC BAX PMC7520849__F1 RAD51 function during HR and replication fork reversal and protection PALB2 GEN1 CDX2 BRCA2 SLX4 RAD51 DNA2 BRCA1 PMC7020766__F3 Pathway of diabetic cardiomyopathy network (Blue circle stands for breast cancer gene IGF1R SOCS3 AGTR1 CSF3 INS CCL2 MTOR CDKN2A ELAVL1 MMP7 TLR4 NOD1 opn LPL NR1H3 IL1B KLK1 NR1H2 CAMK2D ANGPTL4 CAMK2G GADD45A ARHA TNF FOXO1 HMGCR YWHAQ EDN1 LEP EDNRA CYP2J2 PRKCB IGF1 SLC2A4 STK11 ATP2A2 BDNF SIRT1 SOCS1 CD36 PMC6679874__F4 Regulation of genes and myomiRs expression in the IGF/PI3K/Akt signaling pathway during myogenesis MYF5 FOXO3A SMAD2 PAX7 PTEN MTOR MYH2 MEF2C MYOG PMC5161695__F7 Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth HEL-S-49 PCK1 GSK3B PKLR GCK PFKL HEL107 HEL-S-133P HK2 HEL-S-68p PMC4395454__F1 MLK3 Phophorylates AMPK Independently of LKB1 MAP2K1 MAP2 MAP2K4 MAP2K3 MAP6 CDC42 PMC7273095__F1 Androgen sensitivity gateway to COVID‐19 disease severity ACE2 TMPRSS2 PMC3800061__F2 Basic NOD2/RIP2 pathway of NFKB activation TRAF5 TRAF6 TRAF2 NOD2 TAB3 PMC12236749__F3 BMSC-Exos alleviate MIRI FACL4 SLC7A11 PTEN HEL-S-128m FOXO1 SIRT7 TNFSF6 MFN2 TLR4 IGF1 PUM2 A2M HEL-S-44 KLF13 STAT3 BAX BAP1 PMC3251532__F5 The lymphocte-specific gene (A) or urine peptide (B) markers UCN ABCC1 HCCS NBN PTPRCAP CCND2 ZNF107 PMC12236749__F2 BMSC-Exos ameliorate MI ANGPT1 HMGA2 NLRP3 TLR4 MAP3K2 HEL-S-44 PTEN EZH2 BNIP3 ITCH BAX PMC2718437__F4A Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B PLAT PLAUR PLG SERPINF2 SERPINB2 PMC12236749__F5 BMSC-Exos ameliorate other CVDs NLRP3 HMGB1 SMOC2 IGF2BP1 TLR4 KLF4 RAC1 FOXO1 PMC6683488__F1 Molecular landscape of SCLC STAT1 WEE1 ATM ASCL1 SLFN11 MYC EZH2 RB1 ATR IRF-1 AURKA STAT3 PMC11667561__F7 Illustrates the TCA cycle, MVA Pathway and downstream of saponins synthesis metabolic pathway F2 RB1 IPP PMC12236749__F4 BMSC-Exos improve AS HMGA2 NLRP3 KEAP1 PTEN ABCA1 CEBPB GSDMD PMC539208__F2 MAPK pathway BRAF FOS MYC CR2 AKAP9 JUN CR1 PMC9604498__F10 Model integrating the network involving Churc1, Nodal and Notch-dependent pathways in the induction and segregation of germ layers in the Xenopus MZ SOX2 NODAL ZEB2 NOTCH1 TBXT HES4 CHURC1 PMC3956974__F3 Signaling control of CAR activation EGF EGR1 GRIP1 EGFR PGC PMC12236749__F6 Cardiovascular-derived exosomes regulate the bone FZD3 DKK2 PMC11395599__F4 Illustration of NETs, ROS, cancer mitochondrial oxidative damage and altered glucose metabolism, including the Warburg effect and glucose metabolic reprogramming, in human cancers is shown PSAT1 PSPH MTHFD1 MTHFD2 PHGDH GLS PMC9456504__F1 Antimicrobial Peptides in Gynecological Cancers NR1i1 CCND1 SLPI CDH2 CYP27B1 PMC4248747__F8 Proposed model for the control of Beta-catenin stability by RNF220/USP7 APC RNF220 PMC3483307__F5 Novel Genes and Pathways Modulated by Syndecan-1: Implications for the Proliferation and Cell-Cycle Regulation of Malignant Mesothelioma Cells EGF HS2ST1 FOS SMAD2 TGFBR1 EGFR RELB MYC MAP2K3 SULF1 DCN NFKBIA CDK2 GRB2 JUND TGFA PMC7338561__F2 Depiction of the modulation of NFKB signaling pathway by gastric microbiota, especially H NOD1 MYD88 PMC8698353__F5 Effect Mechanism of Electroacupuncture at ST36 on the Injured Extensor Digitorum Longus in the Jumping Rat Model Based on mRNA-Seq Analysis CASP3 CISH MYC APP BCL2 CDKN2A BAX PMC4594238__F8 Sensory initiation of a co‐ordinated motor response: synaptic excitation underlying simple decision‐making TG PMC9532118__F1 E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration RARA SMAD2 SMAD6 SMAD4 TNF SMURF1 SMAD1 DKFZp781O1323 PMC9641500__F2 Lysophospholipid Mediators in Health and Disease APOM PC MFSD2B LPL SPHK1 LPA LPP SPNS2 SPHK2 PMC6745708__F1 The RTK signaling network and nodes of therapeutic blockade EGF RET IGF1R HGF ALK EGFR GDNF MTOR PMC6943215__F1 The ‘Metro-Rail Concept’ to targeted therapy of the pathophysiology of cirrhosis CD14 HGF PMC12001479__F4 Key molecular mechanisms governing mitochondrial dynamics, biogenesis, and mitophagy MFN1 PINK1 MFN2 MTOR OPTN TFAM OPA1 PMC3438338__F7 Interferon-Gamma-induced glial cell activation by transforming growth factor B1: A role for STAT1 and MAPK pathways STAT1 GRB2 TRAF6 JAK1 TGFB1 PMC2790720__F2 IRF4: Immunity. Malignancy! Therapy? SQLE PC SCD MYC PC4 CCNC IRF4 STAG2 CDK6 PMC5515402__F3 Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids HSPA14 INSRR HSP90AB1 FLNA OSTM1 HBXBP KLHL38 TSSK1 HEL-S-162eP PMC3304673__F1 Association of the canonical interferon pathway with the IRF5 haplotype STAT1 IFIT3 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFITM1 IFNG MX1 PMC3795344__F3 Schematic diagram illustrating a proposal for the involvement of Cdx2 during progression of cancers through the serrated pathway BRAF CDX2 CDKN2A PMC7281370__F2 Carbon metabolism in Synechocystis PCC 6803 FIG4 TNLG7C HEL107 RPE PMC12127422__F9 Oxy-inflammation mechanism, Nrf2 and NFKB signaling pathway and regulation of the NLRP3 inflammasome IL10 NLRP3 COX2 KEAP1 BCL2 BAX PMC6421779__F1 Canonical pathway for miRNA biogenesis PAN2 DGCR8 PAN3 DROSHA RAN PMC4073476__F3 Bile Acids are Nutrient Signaling Hormones PC IRS1 NR1C1 PMC4353379__F2 Proteins implicated in neurodegenerative diseases are involved in multiple steps of the miRNA biogenesis pathway AGO1 DGCR8 DROSHA FUS PMC2277398__F1 MAP kinase pathway analysis of the meta-modes NLK PAK1 NEK6 DAO MAX TRAF6 MAP3K7IP1 PMC2718437__F2A Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B BAMBI MAPK9 RUNX2 SMAD2 TGFBR2 SMAD4 BMP4 FST NOG opn MAPK1 THBS1 SKI JUN RUNX3 FOS SMAD6 ENG LTBP1 SMAD9 LEF1 CREBBP JAK1 SMAD1 TGFB1 DKFZp781O1323 INHBA STAT3 PMC3724417__F2 Signaling Mechanisms in Mammalian Myoblast Fusion VASP PTGFR FGF6 GSK3B RELB SMAD4 DOCK1 COX2 NFATC2 KLF4 GHR TEF SRC KLF2 SP1 TRIO CDC42 PMC4569015__F2 Control of cell cycle transcription during G1 and S phases E2F8 E2F7 E2F6 CDK2 E2F2 E2F3 PMC8143192__F3 Therapeutic Potential of HUMSCs in Female Reproductive Aging HGF IGF1 MTOR BAX PMC9164040__F3 Glance at the Molecules That Regulate Oligodendrocyte Myelination RAB35 SOX2 FGF2 NRG1 GIP ARHA PTEN RHEB TSC2 TSC1 FGFR1 BDNF GPR37 PMC10920255__F1 Macrophages participate in mediating inflammatory pain in GA NLRP3 TLR4 PMC9164040__F2 Glance at the Molecules That Regulate Oligodendrocyte Myelination PC GSK3B TCF7L2 PMC5864197__F7 Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection MDM2 ORAI3 SGK1 ELL PMC8284850__F5 Intratumoural fibroblast heterogeneity in pDaC STAT1 PDGFRA IL13 LIF CD44 SHH IRAK4 CXCL12 STAT3 PMC10920255__F2 Gut bacteria and their metabolites can reach blood vessels, exert local effects in joints, modify macrophage-mediated inflammation and influence GA pain through breaches in the intestinal barrier NLRP3 TLR4 MYD88 PMC8400324__F1 Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention PTEN MTOR PMC6477749__F5 Re-analysis of 15 selected genes by KEGGpathway enrichment CDC20 E2F4 CDK2 MDM2 SMAD4 DBF4 RAD21 CDK7 PCNA SKP2 PMC4040894__F2 Heme biosynthesis ABCB6 FECH UROD SLC25A38 UROS HMBS CPOX ABCB10 PMC5700962__F11 Apoptosis pathway(red, up-regulated) BAD AIP NGF TRADD ATM CASP2 CAD FADD HRK BAX PMC5700962__F10 Thyroid hormones pathway (red, up-regulated) BAD MDM2 PFKFB2 SRC HIF1A PFKP RHEB GATA4 PMC5700962__F13 Wnt signaling pathway pathway(red, up-regulated) ROCK2 BAMBI NLK INVS SIAH1 APC SOST SMAD4 SKP1 ARHA PMC5700962__F12 Cell cycle pathway(red, up-regulated) E2F4 SMAD4 CCL4 DBF4 CDK7 CDC20 SMC3 CDK2 CD7 MDM2 PCNA SKP2 MYT1 PMC2891151__F1 TGFB ligands signal through the type I and type II TGFB receptors NODAL CDK2 SMURF2 MYC SMAD6 CDK4 CDK6 PMC12010877__F8 Growth status of tea plants under drought stress with and without the exogenous application of tea polyphenols MYB CAD PMC3233056__F7 Different expressed proteins indicated in glycolysis, TCA cycle, pentose phosphate pathway, nucleotide metabolism, amino acid metabolism, and cell wall development PTS CIT PMC9100643__F3 Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes PTS HEL107 PMC9490947__F8 Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury HMGB1 TLR4 PMC6524185__F7 Differential genes: the PI3K-Akt signaling pathway BAD PTEN EIF4E MTOR RHEB TSC2 PI3 MDM2 SYK MCL1 EIF4B RBL2 CD19 PMC5351668__F6 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets HEL-S-62p KL F10 PLAT VTN LYN PROC PROCR C4A CFI PMC2890502__F2 The yeast MAPK signalling pathways deposited in KEGG FAR1 SIT1 CDC42 PMC4427840__F4 Pathway map of the Prtostaglandin E2 receptor signaling CCR5 HGF COX1 CREM CREB1 HRAS PMC5351668__F5 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets SLC27A4 HEL-S-28 CPT2 HEL-S-104 UBC PLTP FADS2 ACADL CPT1A LPL RORA APOA2 ACADM PMC4427840__F3 Pathway map of the histamine receptor response in dendritic cell IRF8 CREM CREB1 PMC5822798__F1 Activation of TLRs during heart failure TBK1 HMGB1 TNC TLR4 TLR9 TRAF6 IRF3 MYD88 TLR3 PMC11956240__F8 Interaction analysis of the differentially expressed proteins and metabolites involved in the top 10 enrichment pathways DAO SHMT1 GPT ALDH3A2 AADAT ABCB11 CYP1A2 GCDH AOX1 ALDH5A1 ALDH7A1 GOT2 PC KMO SLC22A7 GPT2 ACACB ME3 PCK2 CAD ARG1 UGT2B4 UGT1A1 AGMAT ALDH9A1 UGT1A3 PYCR2 UGT1A9 ME2 HEL-S-30 SULT2A1 OTC GLS2 NAGS CYP2E1 ACSM3 CFTR SLCO1B1 CYP2C9 ABAT CYP3A4 AFMID ASL GLUD1 ALDH2 PMC11840736__F2 Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease PICALM BDNF PMC8335696__F7 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway MAP2K1 VCAM1 IRAK1 MAPK10 EGFR GRB2 MAPK14 IRAK4 MYD88 MAP3K7IP1 SELE STAT3 PMC6043790__F1 Phospholipid synthesis pathways CDS1 PC INS PSD2 PMC4661888__F3 Gene expression analysis of thyroid hormone synthesis pathway TSHR DUOX2 TPO TG DUOXA2 PMC4573710__F12 Proposed model of HDAC10 regulation in G2/M transition HMGA2 CCNA2 HDAC10 PMC4531432__F1 Signaling pathway by which GUTK inhibited tumor metastasis in HCC (for abstract PS01-001) RHO RAC1 CDC42 PMC4637208__F4 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts SQSTM1 CCL5 ACOT9 PCYOX1 FH ACO2 HEL-S-304 SCARB2 PFKP HEL-S-133P FASN ME2 HEL-S-30 M6PR ENO1 DLD PSAP HEL-S-87p HEL-S-130P GFPT1 HEL-S-162eP HEL-S-68p TFEB COX17 SUCLA2 ACLY HEL107 ACADM CYCS PMC3891361__F8 Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA HES5 GFAP NOTCH1 PMC8980269__F1 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy NDRG2 SDCBP SOX2 MAEL HEL-S-53e BMI1 MTOR GPX3 RAP1A DNAJB6 IQGAP1 MCM10 TRIM27 SLC39A6 IGFBPL1 CCL3 PMC8980269__F2 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy TSC2 PTEN DEPTOR RHEB MLST8 PMC4637208__F2 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts POR UNG PTER PMC9550351__F1 Emerging roles of microRNAs in the regulation of Toll-like receptor (TLR)-signaling IRF7 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 TAB3 PMC8699891__F5 Molecular Basis of Accelerated Aging with Immune Dysfunction-Mediated Inflammation (Inflamm-Aging) in Patients with Systemic Sclerosis BAX PMC8984994__F1 Advances in understanding of the innate immune response to human norovirus infection using organoid models STAT1 TLR7 STAT2 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IFNG PMC9016280__F2 Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases BAD MTOR SIRT1 PMC5499780__F1 Action of lenvatinib and everolimus.Notes: Lenvatinib inhibits RTKs on endothelial cell and cancer cell VHL MTOR PMC4643792__F3 Dietary phytochemical alters caste-associated gene expression in honey bees ZYX EGFR APP PMC9313263__F6 High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer EGF EGFR RPS6 PMC5615248__F2 Regulation diagram LFNG NOTCH1 PMC3084093__F4 Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion PIK3R1 ERBB2 PDGFA TGFBR1 EGFR TGFBR2 VWF ITGA4 ITGB1 TRAF2 SHC1 PS1TP5BP1 PMC4473262__F4 Human Blood Metabolome-Transcriptome Interface PC PROC PMC3636692__F3 The VEGF-DLL4-Notch signaling pathway in angiogenic sprouts NRP1 NRP2 PMC9006576__F1 Emerging role of RNA sensors in tumor microenvironment and immunotherapy TBK1 TLR8 TLR7 IRF7 TRAF3 TRAF6 IRF3 MYD88 NOD2 TLR3 MAVS PMC5243832__F1 Activation and regulation of complement pathways relevant to Borrelia spp CD59 C9 C4B_2 MASP1 MBP FH C1S C4A PMC6119098__F4 E-cadherin in Contact Inhibition and Cancer APC GSK3B PMC6119098__F2 Regulation of the Hippo signaling pathway PATJ NF2 AREG PALS1 SRC AJUBA CRB3 PMC11172217__F10 FGF5 promoting secondary hair follicle growth LEF1 FGFR1 RNF43 HGF NOTUM WAS DKK2 BAX PMC10741648__F1 Reelin signaling pathway VLDLR SRC DAB1 CRK CRKL PMC5448101__F8 Ubiquitin editing in the Imd-signaling pathway DAP FADD PMC9128178__F7 Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer ERBB2 CDK15 MYC CCND1 CDK4 CDK6 PMC7650809__F1 CTLA-4 pathway: (A) T cell activation in response to the tumor-associated antigen requires 2 signals CD80 PMC5789329__F5A Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach PROK2 PMC9243315__F3 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine GPC5 RUNX3 TP63 EGFR BTG1 NPTX1 PMC9243315__F2 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine EREG GPC5 RUNX3 SOS2 EGFR TP63 USP28 VEGFA NPTX1 PC ERBB2 GC BTG1 BAX PMC10036653__F8 ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival TBX20 BMP2 PMC7847674__F2 Signal transduction mechanisms activated by ovarian steroid hormones on endometrial autophagy COX2 ULK1 PGR TF PMC4728676__F1 Molecular and cellular mode of action of energy disruptors TSC2 PTEN PHGDH CAMKK2 PMC4227529__F1 Metabolic shifts through the hexosamine biosynthesis pathway (HBP) and protein O-GlcNAcylation in cancer OGA OGT PMC3821664__F4 Biosynthetic pathway of major phospholipids in vascular endothelial tissue and mononuclear leukocytes PC TG HEL-S-5 PMC8649922__F1 Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy LDLR ACSS2 ACLY TG SIRT1 HMGCR FASN CD36 PMC5107940__F7 Proteomic adaptation of small intestinal mucosa in response to dietary protein limitation LAT2 CLDN7 SLC7A7 PMC9657665__F1 Cellular Senescence in Metabolic-Associated Kidney Disease: An Update CDK2 CDK4 SIRT1 CDK6 PMC3303935__F1 Toll-Like Receptors in Chronic Pain HMGB1 CD14 TLR5 TLR9 CXCL10 CXCL8 IRF3 MYD88 TLR3 LTA TLR7 TLR4 IL1B CCL3 PMC3259275__F2 ATM interaction with metabolic signaling pathways IGF1R IGF1 ATM GPX1 PMC10979625__F8 Brief figure summarizes the FGF2-FGFR1-p21 regulatory pathway in FGFR1 amplified ER + BC cells FGFR1 CCND1 STAT3 PMC5908125__F9 Glyoxalase 1 (Glo1) sustains the metastatic phenotype of prostate cancer cells via epithelial‐to‐mesenchymal transition (EMT) control: involvement of miR‐101, hydroimidazolone (MG‐H1), argpyrimidine (AP) and TGF‐B1/Smads signalling pathway GLO1 SMAD2 SMAD4 HEL113 PMC9223569__F1 Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy DES UGT8 CERK SMS KDSR PMC7520695__F3 Signaling pathway of IL-1B and IL-18 IL16 TRAF6 IL1R1 MYD88 PMC7520695__F2 Canonical pathway and activation mechanism of inflammasomes and outcomes in cancer NLRP3 MYD88 GSDMD PMC11725820__F1 Canonical type I IFN signaling pathway STAT1 STAT2 IFNK IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC7240857__F1 Different expression of MAPK8 in breast cancer samples to normal samples FGF21 RETN EGF PGR ALK ACACA GPT EGFR INS MYC APOD PTEN MTOR POR MTTP CHEK2 AMH ATM CRP RBP4 ABCG2 FASN VEGFA HFE TNF HRAS KRT18 NR1C1 AURKA CYP2E1 TM6SF2 APOB LEP EP300 ERBB2 CDK2 GNAS TGFA PMC5367651__F4 Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells BAD IKBKG CDKN1B GSK3B PTEN MTOR FOXO1 CREBBP PDGFA NFKB1 GRB2 CCND1 BCL2 RAF1 SOS1 AKT3 PMC5367651__F3 Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells PERP IGF1 ATM BBC3 PMAIP1 MDM2 CASP9 ZMAT3 PTEN CYCS PMC6515203__F5 Main signaling pathways activated by growth factor signaling through receptor tyrosine kinases (RTK) and the importance of Mg2+ TSC2 EGFR GRB2 SRC STAT3 PMC5883056__F8 Compound 1G with the intermediate signaling pathway EGF EGFR SKP1 SP1 SKP2 PMC5883056__F7 Signal transduction Pathway analysis of the possible drug target FGR, ESR1 and GCRA and their localization FGF4 FGFR1 IGF1 ALDH2 PMC2677552__F3 PharmGKB pathway diagrams CYP2B6 CYP2C9 NR3A2 CYP2C19 CYP3A4 HSD17B1 PMC4209605__F1 Cutting the brakes and flooring the gas: how TMEPAI turns TGFB into a tumor promoter SMAD2 MYC SMAD4 RHO PTEN PMC5831574__F8 Analyses of the potential molecular mechanisms of EPB41L4A-AS2 by a bioinformatics-based method XCR1 LRRC4 P2RY1 ROCK1 BAG4 TGFBR1 TNF MTOR EPB41L4A TAOK1 BMPR2 NFATC2 IGF1 THBS2 SESN3 RAPGEF6 MAPK1 NTRK2 ELMO1 PMC7527411__F7 Proposed model of maternal combination exposed diet effects on cardiac network signaling in offspring GSK3B MTOR PPARG PMC9012636__F14 Study on the Mechanism of Üstikuddus Sherbiti in Ischemic Cerebrovascular Diseases: Based on Network Pharmacology TNC PTEN COL1A1 GLA POLI PMC7763629__F2 RTKs (EGFR) signal transduction and are a target site for small molecule and monoclonal antibody in glioma treatment EGFR PTEN MTOR PMC11998497__F9 PRRSV nsp5 protein interaction that accelerates the ubiquitination and degradation of Nrf2, thereby antagonizing its antiviral activity KEAP1 IRF9 NFKB1 RELA IRF3 TYK2 JAK1 HMOX1 NQO1 PMC8666006__F7 MLH1−/−-mediated cGAS activation and immunotherapy CGAS RAD51 PMC3326558__F8 Schematic illustrating estrogen-dependent regulation of miRNA (miR)-34b expression, its target genes and tumor growth CCND1 PMC4743853__F6 Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells HGF GRB2 PMC5754244__F7 MUC1-C INDUCES PD-L1 AND IMMUNE EVASION IN TRIPLE-NEGATIVE BREAST CANCER MYC BMI1 PMC2676316__F2 Isoprenoid Metabolism and the Pleiotropic Effects of Statins VAT1 ARHA RAC1 PMC1856251__F3 Molecular characterisation of non‐absorptive and absorptive enterocytes in human small intestine CCNA2 PLK1 GSK3B CCNH RB1 CDK6 CCND2 CHEK2 MAD2L2 ATM CCNB1 MDM2 CDAN1 CDK4 PTTG1 CCNE2 CDC14B UBE2F APC CCNB3 PTTG2 CDC20 EP300 CDC6 CDK2 CCNB2 ATR MPEG1 TGFB1 PCNA SKP2 MYT1 PMC6304355__F5 Distribution of target proteins of SBD on the compressed ‘NSCLC-pathway.’ Four pathways form the tubular NSCLC pathway EGF MEI1 EGFR TNF CASP3 COX2 MDM2 CASP9 CSA2 ATR STAT3 CDC42 BAX PMC7055240__F3 Cholesterol biosynthesis pathway and gene expression identified through RNA-seq PMVK MVD DHCR7 AACS FDPS DHCR24 MVK HSD17B7 ACLY HMGCR PMC4818393__F4 Integrative analysis of pathway features and the associated metabolites TH CTH HEL-S-87p PMC11353016__F2 Molecular drivers regulating hair follicle fate specification and the initiation of its growth EDAR LEF1 PDGFA SHH FGF20 PMC9402976__F5 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer TYK2 SP1 STAT3 PMC7970325__F14 Statistically significantly enriched gene ontology (GO) molecular processes (GO-terms) identified for 871 differential genes between radioiodine resistant cancers and other thyroid cancer samples CTDSP2 FGF4 HEL-S-99n AKR1C1 MIOX RHBDL3 AKR1C2 PDIA5 HYOU1 XBP1 KLHDC3 HEL-S-125m PLSCR4 AKR1E2 RNF5 SRPRA RNF175 SDF2L1 DNAJB2 ADGRG6 KCNK2 KCNAB1 PMC9402976__F2 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer LYN GRB2 STAT3 CBL PMC7970325__F10 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular adenoma (FA) KAT5 CARM1 PALB2 SMUG1 FANCD2 TDG HEL-S-1 MYC NBN CREB1 POLL SERPINB5 UNG CDKN2A BACH1 SIAH1 POLE ZNF350 PERP MBD4 MSH6 MDM2 ZMAT3 ARFGEF2 RAD50 RAD52 RAD51 MSH3 MSH2 SP1 CASP8 FDXR STEAP3 AREG IRF9 CD82 BRIP1 MDC1 RAD51D TOP3A XPC CARD16 DDB2 PRH2 LIG1 RAD9A DDB1 BRCA1 CREB3 XAB2 RAD54B PPM1D SESN1 ERCC2 ATR PCNA CDC42 TERF2 HIPK2 SFN BLM CDKN2D EGFR PTEN GPS2 NEIL1 FEN1 ATM ATF4 POLR2A DDX5 PRKDC XRCC3 JUN RAD51C HMGB1 NEIL2 RPRM NEIL3 DROSHA HDAC1 MPG RFC2 CREBBP EP300 RAD17 PIDD1 FANCL MUTYH FANCA TRAF2 FANCB DYRK2 FANCE MYT1 PMC8645759__F8 Notch‐1 signaling promotes reattachment of suspended cancer cells by cdc42‐dependent microtentacles formation NOTCH1 CDC42 PMC10755271__F6 Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf MAPK8 HSP90AB1 EGFR PDPK1 STAT1 BTK KDR F2 GNG2 PTPN11 SRC IL2 MAPK1 ELANE ARG1 JUN PLG FOS FGF2 MMP9 VEGFA ARHA RAC1 IL6 HEL-S-87p TNF HRAS HEL-S-130P EP300 MAP2K1 IGF1 NFKB1 LCK GRB2 JAK3 SYK RAF1 GNB1 PMC3972113__F13 Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NFKB Activation and Enhances Erythroid Differentiation Arrest TRAF6 MYD88 TLR1 TNFAIP3 TF TIRAP PMC10502012__F5 Proposed mechanism for PHT1 mode of action TLR8 TLR7 TLR9 NOD1 MYD88 TASL NOD2 PMC11997203__F1 PI metabolism and the PI3K/AKT signaling pathway in cell dynamics SYNJ1 PKP1 PIP4P1 PIKFYVE IPMK PTEN OCRL INPP5E MTM1 INPP4A PMC4152414__F2 Coactivator dependent signaling regulates various biological functions, and deregulation causes diseases IL6 PMC8516775__F6 Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach CDX2 KLF4 MUC2 PMC11898953__F9 Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways MTOR STAT3 PMC11831486__F3 Tumor type‐specific protein network profile IL3RA MARCKS GNB2 MAP2 FLNA KRT19 GSK3B GNG7 GNG10 FLNB MTOR COL1A1 ITGA2 GNG4 MAP1B TLN2 GNG2 COL1A2 SRC HEL114 THBS1 CSNK1A1 PCK2 COL2A1 GAL PREX1 ELMO1 FOXO3A HEL-S-34 ADD2 GSK3A ARHA CTNNA1 LMNA KRT18 GNG8 TSC2 THBS2 VTN HNRNPC CTNND1 TNR RAF1 CTNND2 AKT3 PMC7697405__F2 Simplified schematic representation of the hyperactivated mammalian target of rapamycin (mTOR) signaling due to seizures TSC2 TSC1 MTOR RHEB PMC9020238__F2 Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator TRAF6 HEL-S-92n MYD88 TLR1 PMC11997203__F5 PIPn signaling at the cytoskeleton in the regulation of cell dynamics CEP164 CDC42 PMC8355620__F4 Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions KIF7 APC GSK3B LRP5 MYC SMAD4 LRP6 EDARADD EDAR SUFU GRB2 SHH SMO SMAD1 PMC6998363__F5 hsa-miR-4638-3p and hsa-miR-1273 g-3p Target Gene Network Map IGF1R TGIF2 NODAL ROCK1 EGFR SMAD2 sm-M20 SMAD4 SHC3 PRKCA FLT1 BMPR2 FYN VAV3 ACVR2B TLN2 ITGB3 SMAD6 PPP2R1B ID1 PDGFC IGF1 BMPR1A ERBB2 SMURF2 ACVR1B TNR SOS1 MYLK3 AKT3 INHBE PMC9376100__F4 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) GSTM2 TNFAIP3 PMC9376100__F6 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) CCR5 CCR2 SMAD2 SMAD4 IL11RA RHO MTOR OSM STAT3 PMC4699200__F9 TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGFB Receptor Pathway in Human Aortic Endothelial Cells SMAD2 TGFBR1 LPL SMAD4 ATF3 PMC2670967__F2 Schematic (simplified) representation of enzymatic and metabolite components of the liver methionine metabolic pathway, and the influence of ethanol consumption HEL-S-61p HEL-S-182mP PMC9347431__F5 Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection STAT1 CXCR3 STAT2 CXCL10 IRF3 TYK2 JAK1 MAVS PMC4705964__F8 Working model for Gpr175 function as an enhancer of Hh signaling SUFU PTCH1 SMO PMC4788539__F7 Schematic model recapitulating the role Shoc2 plays in controlling ERK1/2 activity EGF LGALS3BP SHOC2 PMC1974887__F1 Endogenous Synthesis of Coenzyme Q in Eukaryotes COQ3 COQ2 COQ6 COQ5 PMC5858900__F1 Multifaceted Fanconi Anemia Signaling FANCD2 BLM FAAP24 FANCM FANCA FANCE PMC6315117__F4 Pathway analysis graph of G1/S checkpoint MAX SUV39H1 ATM MDM2 SMAD4 BMI1 SIN3A ATR PAK1IP1 PMC11599189__F2 Figure illustrates the various functions and molecular interactions of circFOXP1 in cellular processes KDM5B PTBP1 MSC MTOR STAT3 PMC3128904__F2 NOD-like receptor (NLR) family and inflammasome CARD9 NOD1 NOD2 PMC3128904__F1 Toll-like receptor (TLR) signaling pathway TBK1 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC12030433__F5 Carotenoid metabolic pathway SI POR CCS PMC6991631__F7 Proposed model of mifepristone for the treatment of adenomyosis CDK2 CXCR4 CDC2 CDH2 PMC3374974__F2 EphA Receptor Signaling – Complexity and Emerging Themes TSC2 RICTOR TSC1 GRB2 PTEN RAC1 MTOR EPHA2 RHEB PMC7384889__F4 Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes WNT1 LRP5 LRP6 PMC5279903__F1 Molecular mechanisms of JNK1 and JNK2 in obesity-driven insulin resistance TSHB FGF21 NCOR1 ATF2 IL6 JUN IRS1 PMC9289261__F2 Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization MYD88 PMC4135311__F2 Sirt1/AMPK/PGC1/PPAR signaling network NR1C1 FOXO1 PMC3385949__F1 FOXO proteins are involved in multiple signaling pathways that control cell proliferation, apoptosis, survival, and immune functions in response to external and internal stimuli EGF IGF1 NGF IL3 EGFR MDM2 FLT3 PMC3573758__F2 Development of allergic inflammation BTK FYN GAB2 LYN SYK SPHK1 PMC3073290__F1 Models of how IFNB and GA activate PI3KD/Akt and MEK/ERK pathways to induce sIL-1Ra production in monocytes STAT1 IFNAR2 IFNAR1 PMC8958363__F7 Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages HEL-S-89n MAN1B1 FANCD2 GANAB DNAJB9 PDIA2 SEC23A DDB2 KDELR1 XBP1 HEL-S-125m USO1 DNAJB11 HEL-S-269 BRCA2 ATF4 ATRIP RAD50 RAD51 B4GALT4 ATR UGGT1 PMC9492418__F6 B-Cell Translocation Gene 2 Upregulation Is Associated with Favorable Prognosis in Lung Adenocarcinoma and Prolonged Patient Survival NFKBIA R3HDM2 BAT2L RELB CNOT3 IGF2BP2 PMC4253858__F1 EGFR signaling pathways and receptor cross-talk IGF1R HGF EGFR MTOR AXL PMC3462113__F1 Main metabolic reactions in central carbon metabolism.A) Xylose can be assimilated through two pathways: the fungal oxidoreductive pathway consisting of XR and XDH or the bacterial isomerization pathway via an XI PIG59 PDC PC CIT RPE MDH2 PMC2853973__F1 Kaposi's sarcoma-associated herpesvirus and innate immunity TBK1 TLR4 CXCL10 IRF3 PMC6665304__F6 DISC1 at the synapse PAK1 TNIK DISC1 RAC1 PMC6665304__F4 DISC1 regulates neurogenesis via Wnt/Beta-catenin signaling DISC1 GSK3B PMC8469001__F6 LRP1B: A Giant Lost in Cancer Translation LRP1B APP PMC5355523__F7 Putative mechanism for the interaction between miRNA and the Ago2, Pum2, and REST proteins AGO2 AGA PUM2 TET3 HDAC2 REST MOV10 FMR1 HDAC1 PMC6863373__F2 Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies ATF4 SMOX GADD45A PMC4633443__F1 Inflammasome axis NLRP3 CD14 NLRP2 IL1B PMC8999913__F6 Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum SRM CERS5 CERS2 PMC7328520__F6 nc886 and cancer EIF2A MYC STAT3 PMC9537379__F3 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions AID GC POU2AF1 CD80 GRAP IRS1 PMC4122622__F1 Crosstalk of BMP and neurotrophin signaling in neurons SMURF1 PMC6354331__F5 Enrichment analysis with DAVID 6.8 of the associated genes for the 4 novel diseases and COPD POR PMC9537379__F5 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions STAT1 EBI3 CD80 GRAP STAT3 PMC5133374__F4 Immune response_IL-17 signaling pathway CS IL17F TRAF6 CCL7 JAK1 SP1 IL17RC PMC5146691__F1 Implications of cell biological processes on innate immune signaling CD14 TLR4 IRF3 AIM2 IRF-1 PMC6239905__F12 Metabolisms of SGG in seminiferous tubules: interrelationship between testicular germ cells and Sertoli cells PMC4216471__F4 The molecular cascade downstream of Nodal and Activin A signalling in EpiSCs ACVR1 IFRD1 NODAL CRIPTO ACVR1C GSK3B SNAI2 ARHA MIXL1 SOX17 ID3 GATA4 FOXA2 ACVR2B GIG8 MMP2 ACVR2A CXCR4 ACVR1B CCND1 GSC FOXH1 PMC7324512__F6 Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway VGLL3 AMOTL2 LATS1 LATS2 PMC2729380__F6 Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes PML CEBPE EGR1 TSC22D3 BIK HEL-117 EIF4E SKI PXN SP100 TAPBP PMC5146691__F5 Biosynthetic pathway: nucleic acid detection from within the cytosol TBK1 CGAS TRAF5 TRIM2 TRAF6 TRAF2 AIM2 MAVS IFI16 PMC6307429__F3 Role of the NFKB pathway in the miR-155/SOCS1 axis in the immune system TLR4 TRAF6 MYD88 SOCS1 PMC4950325__F6 Schematic representation of the metabolic pathway leading to the activation of vitamin D3 to calcitriol CYP27A1 VIT CYP2R1 CYP24A1 CYP27B1 PMC7902901__F3 Merged network of Reactome pathways identified by all models (2.1 to 2.5) TYSND1 SOX2 SET RUNX1 BCR RHO ACD SHC1 ELL HEL-S-5 PMC7902901__F5 Induced regulatory network of smooth muscle cell contraction SP2 SMAD2 SMAD4 TLN1 PTEN ANXA6 GATA4 CREBBP NKX2-5 HEL-S-273 SP1 SP3 CALD1 FOXH1 PMC4804208__F6 Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production PC CIT MAL PMC4013140__F7 The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells SMAD2 SMAD4 PMC7744575__F6 Schematic diagram illustrating the role of proteins encoded DEGs and DASGs and others on AMPA-receptor signaling and synaptic plasticity SLC8A2 SYT7 NAPA PMC5089864__F1 Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network PGM2 GAL PMC8531299__F1 FASN and the cell death decision circuitry controlled by the BCL-2 family BAD BIK ACLY BMF HRK FASN BAX BOK PMC5892715__F1 Breaking up with ATM RNF8 ATM MDC1 H2AX PMC8073244__F3 Viral Infection Modulates Mitochondrial Function IRF7 IRF3 MAVS PMC6193074__F10 Cardioprotection by AsIV through CaSR/IP3R pathway BAD CASR DLD GATA4 PMC11011684__F3 Gene Expression Patterns Associated with Survival in Glioblastoma PRKCA PLCG1 EP300 NGFR YBX1 EGFR COL1A2 SMAD4 RHO MTOR WIF1 PMC6959132__F4 Pathway for signaling from p75–Nogo receptor complex to RhoA ROCK2 ARHA LINGO1 PMC3357504__F3 Translation initiation control relays signals to erythroid and granulocytic differentiation SET BCR EIF2A EIF4E MTOR PMC8432624__F2 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins COPRS MTDH BTG2 PMC6959132__F6 BDNF-signaling pathway mechanism PI3 NACA2 BDNF PMC3357504__F2 Translation initiation control during growth factor stimulation, cellular stress, and cellular physiology ELF2 TSC2 TSC1 SET EIF2A PTEN EIF4E MTOR PMC4011580__F6 SCFBeta-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway SKP1 PTEN RBX1 NEDD4 PMC8432624__F5 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins EGFR VEGFA STC1 HEL-S-66 PTEN MTOR SOX9 PMC2698574__F9 The VACV- and CPXV-stimulated PI3K/Akt pathway of biological relevance in spontaneously immortalized A31 and MEF cells BAD EIF4E PMC2877703__F1 Anabolic and catabolic pathways regulating skeletal muscle mass ELF3 IGF1 MTOR RHEB PMC8685516__F1 Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases EDAR NKX2-3 TRAF3 TRAF6 SMAD1 DKFZp781O1323 PMC8422731__F2 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment CCND1 SRC SIN3A STAT3 PMC8422731__F1 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment EGF EGFR STAT3 PMC4233289__F2 Proposed model for the regulation of mTOR signaling in conditions of overnutrition and the cardiorenal syndrome (CRS) TSC2 TSC1 IGF1 MTOR RHEB PMC20438__F5 Schematic diagram of possible Rad6-mediated metabolic pathways REV1 RAD18 PCNA PMC8528922__F3 Genes involved in the Taxol biosynthetic pathway TH IPP PMC5893168__F7 Signaling pathway predicted to be activated by the miRNA target predictor of IPA CXCR1 COX2 MPO VCAM1 ARG2 SHE CAD PMC2518924__F9 The CEBPD network CEBPD MBP FOS GFAP PMC5031950__F2 PCSK9 and apoB-containing lipoproteins metabolism PCSK9 APOB LDLR APOE PMC3502766__F5 Proposed metabolic pathway for the degradation of VFA and TCE inferred from the metaproteomic data DES PSD PMC10931645__F2 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets APC CD80 TNF LAT PMC10931645__F3 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets APC CD160 CD48 CD96 BTLA CD244 TIGIT LAG3 FGL1 CEACAM1 LTA CD2 CD226 PMC5770609__F3 Crosstalk between the Hh and Wnt pathways forms regulatory loops SUFU APC GLI3 SMO PMC5770609__F2 Wnt signaling pathway leads to the accumulation of Beta-catenin in nucleus APC GSK3B PMC7806208__F5 Pathway schematics of pharmaceutical and ligand interventions of three signaling pathways known to be active in mammalian A549 cells SMAD2 TGFBR1 MDM2 TGFBR2 SMAD4 PMC6276890__F1 Canonical and non-canonical signaling pathways of the AhR AHR CYP1B1 CYP1A1 CYP1A2 PMC6803600__F2 Immunometabolic changes associated with DC maturation TBK1 CD14 CD209 CD83 CD80 NOS2 MTOR IL1B PMC5253683__F8 GA13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3Beta-NFATc1 signalling pathway HEL-S-62p CTSK NFATC1 GNA13 TRAF6 ARHA PMC7693142__F3 Methionine and folate cycle pathways involving PLP-, FAD- and B12-dependent enzymes CTH PMC4091098__F1 Heat shock protein-CD91 pathway mediates tumor immunosurveillance CD40 HEL-S-92n PMC5580204__F4 Signalling pathway in normal and hyperglycemia patients CDK2 CXCR4 MMP9 ROS1 PMC2788007__F1 Simplified representation of the complement cascade PMC6071544__F16 Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward TH HEL-S-26 VASP CS FH CIT MAL PMC8335696__F3 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway MMP3 VCAM1 EGFR MAPK3 MAPK14 MAPK1 HEL-S-162eP PMC8335696__F5 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway FLT4 EGFR MAPK10 MAPK3 MAPK14 TNF HEL-S-22 HEL-S-162eP MMP3 MAP2K1 F2 F3 MAPK1 HEL-S-72p SELE PMC7940178__F1 HCA2 triggers different downstream signaling pathway in different cell types NLRP3 BAD TG PMC4491684__F1 The Hedgehog signaling pathway mechanism SUFU KIF17 PTCH1 SMO PMC5797779__F1 Biochemical function and regulation of indolamine-2,3-dioxygenase 1 (IDO1) IDO1 AHR FOXA1 CTCF IDO2 CD80 CTLA4 COCH STAT5B IFNG FOXA2 PMC7147660__F1 PD-1/PD-L1 pathway and anti-PD-1/PD-L1 agents combination strategies in breast cancer HMGB1 IDO1 CDK4 CDK6 PMC12209598__F2 Redox regulation of metabolism and bioenergetics NLRP3 DGAT1 MPO BCR KEAP1 ATM SYK MTOR PMC5817350__F2 Releases and signalling of IL-33 IRAK1 SIGIRR IL33 TRAF6 IRAK4 MYD88 PMC12209598__F4 Oxidative stress ELF2 ULK1 KEAP1 ERO1A EIF4E PMC3674189__F7 Estrogen receptor B ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis IGF1 PTEN BDNF PMC6020165__F3 Proteasome Inhibitors: Structure and Function BIK JUN PMC7397839__F1 Metabolic Role of PTEN in Insulin Signaling and Resistance GRB2 PTEN MTOR PMC8869711__F1 Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications TSC2 TSC1 GPX1 SELP PTEN MTOR PMC5341000__F6 Role of DHT- and EST-regulated proteins in energy metabolism GGH HADHB PSAP MRPL40 MDH2 RIPK1 HEL-S-67p LETM1 GNPNAT1 HEL-S-111 CAD SUCLG2 HEL107 ECHS1 GLS PMC4452412__F7 Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer SUFU CXCR4 SMO CXCL12 PMC5100792__F1 Isoprenoid biosynthetic pathways and enzymes in Arabidopsis IDI2 IDI1 IPP PMC7295567__F1 The insulin/IGF-1 signaling pathway in regulating FoxO3 activity is conserved between C FOXO3A PDPK1 PMC5351692__F1 Advances in sarcoma diagnostics and treatment EGF BAD APC MDM2 SHH GSK3A SMO PTEN HIF1A MTOR PMC4686024__F10 Comparative Transcriptome Analysis in the Hepatopancreas Tissue of Pacific White Shrimp Litopenaeus vannamei Fed Different Lipid Sources at Low Salinity UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC9637487__F3 Conservation and divergence: Regulatory networks underlying reproductive branching in rice and maize AGO2 OSER1 SPI1 DST SP3 PMC9500642__F8 Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy KLF5 LPA PMC7096759__F1 Pathway map of pyrimidine metabolism depicting de novo, salvage, and catalytic pathways CDA ENTPD8 DPYD CMPK2 SHMT1 DPYS DCTD UMPS TYMP HEL74 CMPK1 DHFR APP DTYMK DUT CAD DHODH GLS PMC4404599__F3 Schematic overview of some of the most significant IPA-identified, canonical host response pathways CXCR1 STAT2 IRF7 IRF9 BST2 HEL-S-99n IL8RB TRAF6 IRF3 CCL2 TRIM25 STAT1 TAP2 VCAM1 CD40 CSA2 IFI35 IFIT1 PMC9515447__F4 USP13 in physiology and diseases TBK1 STAT1 MAVS PMC7948473__F7 Proposed function and mechanism of ppGalNAc-T4 in breast cancer progression SNAI1 SMAD2 SMAD4 PMC9266916__F1 Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-Alpha-Necroptosis Pathway RIPK1 TRADD RIPK3 TRAF2 FADD MLKL PMC4910876__F2 Mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging TSC2 IGF1 OSR1 DEPTOR IRS1 INSR PMC3316754__F5 Ingenuity pathway analysis was used to create a network of biologically relevant genes regulated in response to diet for comparisons control versus diet A, control versus diet B, and diet C versus diet B MYC HUWE1 THRA PMC5946470__F4 CD44-mediated downstream signaling pathways MMP14 HGF MMP9 SRC RAC1 HIF1A HEL-S-133P PMC7274160__F4 Possible signaling pathways of hsa-miRNA-122-3p and hsa-miRNA-200a-5p enriched by the KEGG pathway analyses APC GSK3B GRB2 PMC10968822__F3 Upregulation and downregulation of PD-L1 by YY1 through various factors YY1 PTEN JAK1 MTOR STAT3 PMC12113870__F2 Hesperidin action on the NFKB signaling pathway CAP2 COX2 CAP1 TRADD CYLD XDH OTULIN TAB3 PMC7780193__F1 Cell Energy Metabolism and Hyaluronan Synthesis OGA OGT UGDH PMC7780193__F3 Cell Energy Metabolism and Hyaluronan Synthesis CREB1 YY1 SP1 TNF HAS2 TGFB1 IL1B SIRT1 PMC6493842__F1 Schematic representation of central histaminergic components DAO HDC PMC8865963__F1 Human genetics of SARS-CoV-2 infection and critical COVID-19 TBK1 STAT2 IRF7 IRF3 IFNAR2 MYD88 IFNAR1 TLR3 STAT1 TLR7 TYK2 JAK1 MAVS PMC5586499__F1 Metabolic Abnormalities and Oxidative Stress in Lupus IKZF1 PAX5 TRAF3 MTOR PMC12219042__F8 PKA-NFATs signaling pathway NFATC2 NFATC1 VEGFB MEF2C MYOG PMC2573957__F1 Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination CD14 TLR4 TNFRSF4 IRAK2 LBP TRAF6 IRF3 IRAK4 MYD88 TNLG2B IRAK3 TIRAP PMC3582569__F2 Pathways regulated or induced by the presence of a specific sugar XK NAGA FOS ENO1 RPIA GAL HEL-S-162eP PMC5867295__F5 Processes of hypoxia and angiogenesis and the canonical fibroblast growth factor (FGF) signaling pathway and newly acquired insights into their relation to the development of the osteoarthritic (OA) chondrocyte hypertrophic phenotype NGF RUNX2 COL2A1 HIF1A DDR2 SOX9 PMC6714402__F5 DEGs involved in estrogen and prostaglandin signaling pathways ITPR2 MAPK9 CREB3L2 MAPK14 HBEGF SHC3 CREB3 MMP2 NFKB1 SRC ADCY6 GNAS JUN CREB3L4 PMC5867295__F4 MAP kinase and inflammatory signaling pathways ALPL CXCL1 IL16 ADAMTS5 RUNX2 COL2A1 SP1 SIRT1 COL10A1 CD36 PMC5237206__F2 Summary of three key signaling cascades that may mediate the link between inflammation and epileptogenesis HMGB1 TLR4 TGFBR1 TGFBR2 TRAF6 IRF3 MYD88 PMC5867295__F3 Canonical Ihh/PTHrP and Notch signaling pathways IHH ADAMTS5 RUNX2 VEGFA SIK3 HES1 ATF4 PTCH1 GLI3 SMO EZH2 COL2A1 COL10A1 PMC5867295__F2 Wnt- and TGFB superfamily signaling pathways RUNX2 ATF2 GSK3B SMAD4 DKK1 SOX9 FRZB GREM1 SFRP1 EZH2 AXIN2 APC MATN3 LRP5 LRP6 MAP3K7IP1 ID1 ALPL WNT3 LEF1 SMURF2 SMAD1 DKFZp781O1323 COL10A1 TCF4 PMC5584596__F1 Duvelisib: A Phosphoinositide-3 Kinase D/G Inhibitor for Chronic Lymphocytic Leukemia BCR LYN CD19 PMC8532577__F2 Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling EGF HGF NOTCH1 SRC STAT3 PMC1852551__F4 Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids COX2 ANXA1 COX1 CRABP2 HEL-S-53e ALDH1A2 PMC2559911__F7 Model for the function of SHC-1 in IIS and JNK signaling INS SHC1 PMC11076791__F4 Proposed regulatory network SNAI1 ELF3 NODAL FOXA1 WNT1 SHH GFI1 KIF15 HEL23 PMC3236456__F2 Fungal cell wall pathogen-associated molecular patterns (PAMPs) and their host-pattern recognition receptors (PRRs) IL16 TLR9 PMC10854699__F2 Cachexia-related pathways in skeletal muscle: The mTOR (mechanistic Target of Rapamycin) signaling pathway, which is initiated by activated Akt and inhibits the phosphorylation of FoxO, facilitates the process of protein synthesis IGF1R IGF1 SMAD2 MSTN TNF MTOR IRS1 PMC3236456__F3 Hypothetical model for a molecular chitinase response to chitin-containing pathogens or particles CHIT1 RELA IRF4 PMC4032603__F3 KIBRA in Hippo pathway AMOT NF2 CIT LATS2 FRMD6 PMC8835347__F7 Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells SIRT1 BAX PMC7248305__F2 Many functions of Ns1 and Ns2 STAT1 TLR7 STAT2 IRF7 IRF9 IL4 MAVS PMC7248305__F1 Interferon signaling pathway altered by Ns TANK STAT2 IRF7 IRF9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR3 STAT1 TLR7 JAK1 MAVS PMC9581396__F1 Editorial: Osteoporosis, sarcopenia and muscle-bone crosstalk in COPD CS NFATC1 MSTN STAT3 PMC10893629__F4 Frequently altered signaling pathways in SCLC SOX2 ASCL1 MYC DLL3 LATS1 MOB1A MOBKL1A LATS2 CREBBP EP300 SUFU PTCH1 SHH BCL2 REST SMO EZH2 ME3 PMC4263734__F5 Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells NLK SIAH1 LEF1 APC CER1 SMAD4 SKP1 DKK2 RBX1 CXXC4 PMC4203741__F5 Long-HER Study: Clinical and Molecular Analysis of Patients with HER2+ Advanced Breast Cancer Who Become Long-Term Survivors with Trastuzumab-Based Therapy TSC2 TSC1 PRKAA1 PTEN LPA RHEB PMC7299730__F8 Serpinb6b regulation in uterine decidualization MMP2 WNT4 BMP2 MMP9 PMC2772137__F4 Temporal Profiling of Rat Transcriptomes in Retinol-Replenished Vitamin A-Deficient Testis ACAT1 FDPS HSD3B1 FDFT1 HMGCS1 CYP17A1 ACAT2 PMC9575553__F3 Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer KDM1A KDM7A KDM5B KDM2A MED1 TF PMC7151642__F3 Tumor Suppressive Roles of cGAS-STING CGAS RELA IRF3 SLC19A1 PMC7151642__F2 Independent functions cGAS and STING TBK1 CGAS ATM RELA IRF3 PMC2856900__F7 Moe and Rho1 function in apoptosis based on genetic, biochemical, and subcellular localization data FOS JUN TXN PMC7151642__F1 cGAS-STING signaling in immunity TBK1 RELA TREX1 IRF3 PMC5469704__F1 Stress-induced EGF Receptor Signaling Through STAT3 and Tumor Progression in Triple-Negative Breast Cancer MMP7 MMP9 EGFR STAT3 PMC3083942__F3 Proposed model for Syk in mediating oxidative stress-induced calcium release BTK BASH LYN SYK PMC5377455__F7 Proteomic signature of muscle fibre hyperplasia in response to faba bean intake in grass carp CPT2 RAN HEL-S-5 PMC1434604__F1 Sites of action for reactive oxygen species in the regulation of the insulin signaling pathway PI3 GRB2 PTEN MTOR PMC10896898__F4 Mixed and gene only representations of the original KEGG pathway PRKCA PLCG1 PRKCB RASGRP3 PLCE1 PLCG2 RASGRP4 PMC10896898__F3 Recreated RAS signaling pathway TIAM1 TBK1 RASSF1 RIN1 RASGRF1 GRB2 RHO SOS1 CDC42 PMC6150107__F3 Role of HDACs and associated pathways involved in the processes of autophagy during the progression of DN TSC2 ULK1 HDAC3 ATG3 ATG10 HIF1A FOXO1 PMC5124539__F2 Role of Interleukin-18 in the Pathophysiology of Allergic Diseases IL13 IL4 TNF FOXP3 PMC7686079__F4 APC mediates biased signaling of PAR1 PC APC ARHA RAC1 PMC4905397__F1 Inhibition of tRNA synthetases restores glutathione from the effects of cystine deprivation in ferroptosis GPX4 ATF4 PMC9698586__F3 Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets CPT1A RAN TG CD36 PMC10985190__F2 Nerves promote tumour cell growth and survival The neural impact on tumors is mediated through sympathetic, parasympathetic, and sensory nerves, as indicated by solid lines in the diagram METTL3 NGF EGFR ADRB2 BDNF PMC6387630__F1 Representative pathway featuring multiple enzyme-/non-enzyme-assisted post-translational modifications (PTMs) that control cell-decision making FYN KEAP1 RBX1 PMC2893682__F7 Interaction scheme of Shh and activated Beta-catenin signaling NOTCH2 SHH SMO PMC3587725__F1 Regulation of AMP gene expression through the VDR or FXR pathways IL1R1 MYD88 NOD2 PMC7568806__F5 Top network identified by ingenuity pathway analysis SLC44A1 ANXA3 TMPRSS3 CENPA PMC10985190__F4 Communication between tumor cells and nerves facilitates tumor perineural invasion ROBO3 PLXND1 CX3CR1 CX3CL1 CXCR4 CXCL12 SLIT2 SEMA3D PMC7468437__F6 Gene network of “Rap1 signaling pathway” term enriched in both IgG4-RD tissue proteomic data and LSG transcriptomic dataset HGF PDGFRA ITGA2B SIPA1L2 FGF2 EGFR PFN1 PLCB1 PLCB2 PDGFD FLT1 MAP2K1 PRKCB NGFR DOCK4 FYB1 SIPA1L3 SIPA1 KITLG THBS1 GNAO1 PARD3 FGF7 AKT3 PMC6916202__F12 Major receptors and signaling pathways/proteins involved in atrophy and hypertrophy IGF1R IGF1 SMAD2 F3 GSK3B TRAF3 FBXO40 MTOR TRAF2 IRS1 STAT3 PMC4905226__F2 (See previous page) ATM PARP1 MRE11A PMC2592774__F1 TLR signalling pathways TBK1 COX2 IRAK1 TRAF3 TRAF6 SYK IRF3 MYD88 TNF MAL PMC8079327__F4 Dyslipidemia in breast cancer patients increases the risk of SAR-CoV-2 infection LTA LTB PMC5867882__F2 Mammalian Hippo pathway ECD AREG BIRC5 CD44 TEAD4 SCRIB LATS1 RHO LATS2 FAT4 TEAD2 TEAD3 NF2 FRMD6 PMC6642550__F9 Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation IL18 NTS IL1B PMC6232290__F2 IL-13 signaling mechanisms in the treatment of ulcerative colitis IL13RA2 IL13RA1 IL13 JAK1 IL4 PMC7981165__F2 PI3K/AKT-dominated signaling pathway regulates RUNX2 in PCa PTEN FOXO1 PMC7052942__F2 Verified signaling pathways of YWHAZ in HCC ATG3 HEL-S-101 HEL-S-93 AXL PMC6739099__F8 Identification of DEGs relevant to protein processing in the endoplasmic reticulum pathway ELF2 SEL1L ATF4 SVIP RBX1 PAG1 PMC7673349__F2 Hypoxia regulates CSCs with HIF-1 as the core CD47 SOX2 CD44 SHH HEL-S-53e PMC3577660__F8 Regulation of proteins translation in Jurkat cells ELF3 EIF3A EIF4E MTOR EIF4B PMC5490919__F1 Capsaicinoid biosynthetic pathway CS PMC9531712__F1 Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition DAAM1 ATF2 APC GSK3B LRP5 LRP6 ARHA ROR2 JUN ROR1 CDC42 PMC10917983__F3 Acrylamide promoted cell apoptosis via the miR-27a-5p-Btf3-ATM-p53 signaling pathway, adapted from Zhang et al ATM PARP1 NDUFS8 BTF3 BAX PMC10917983__F2 Biogenesis and mechanism of miRNAs PAN2 AGO2 DGCR8 PAN3 DROSHA XRN1 PMC8395761__F2 Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia BCAT1 EZH2 MTOR TET2 GLS PMC7917119__F9 Proposed model for the mechanism by which induced miR-2187 negatively regulates NFKB and IRF3 signaling expression by targeting TRAF6, thereby avoiding excessive inflammation and immune responses ISG15 IRAK1 TRAF6 IRF3 IRAK4 MYD88 IL1B MAVS MX1 PMC7999827__F4 Apoptosis and cell death pathway PMC9284064__F2 Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target CXCR3 EGFR MYD88 PMC7606733__F5 Enrichment of the Hippo signaling pathway in CCA AFP PATJ GIG8 AMOT AREG APC MYC SCRIB AXIN2 ID1 RASSF6 PMC11551672__F1 Under the tumor microenvironment, abnormally activated wingless/integrated signaling pathway in cancer cells can be interpreted as an M2-tumor-associated macrophage polarization mediator APC GSK3B PMC4747576__F6 Global MicroRNA Expression Profiling of Mouse Livers following Ischemia-Reperfusion Injury at Different Stages CD14 SIGIRR TICAM2 LBP JUN TRAF4 TIRAP PMC7460598__F4 Proposed mechanism by which LOXL2 causes fibrosis and cardiac dysfunction LOXL2 SMAD2 MTOR PMC6139299__F1 Schematic overview of light-regulated translational control pathways in the SCN EIF4E MTOR VIP PMC4137540__F2 Figures accompanying the sensitivity analysis HEL-S-62p C9 C6 BCL2 BAX PMC7937931__F4 ERBB2/VEGFA-AKT-PI3K-VEGFR signaling pathway and autocrine VEGFA signaling loop TSC2 TSC1 IGF1R EGFR VEGFA PTEN MTOR RHEB PMC4854551__F8 Proposed model for the involvement of the EIF2AK4-EIF2A-ATF4 pathway in autophagy response to AIEC infection in intestinal epithelial cells ATG3 SQSTM1 ATF4 EIF2A EIF2AK4 DKFZp762B153 PMC7937931__F3 Relationship between genes and their genetic functions MUC1 EGF IGF1R BAD NR3A2 EGFR MAPK3 MYC PTEN RB1 SLIT2 POR XBP1 PI3 MMP2 ATM FOXA1 SRC CCND1 TFF3 ABCB1 JUN GATA3 PTGS2 APC VEGFA ID1 GRB7 RASSF1 ERBB2 TP73 BCL2 PYCARD PMC5123285__F8 LRRC4 as a tumor suppressor in glioblastoma LRRC4 EGF EGFR TF PMC11598914__F2 Various interactions between RABV proteins and interferon signaling pathway TBK1 STAT1 ISG15 PML STAT2 IRF7 IRF9 IRF3 IRF-1 PMC3965205__F1 Hypothetical mechanisms of tolerance within the TLR4 pathway CD14 TLR4 IRAK1 TRAF6 MYD88 IFNG PMC11012138__F3 Oxygen sensing and HIF pathway activation in embryonic neurogenesis EPO ASCL2 DLX3 PMC4403761__F1 S-nitrosylation in NFKB signaling EGF TLR4 TRADD TRAF6 MYD88 TRAF2 PMC5663315__F1 Schematic representation of the mTOR signaling pathway before discovery of TSC function TSC2 FLCN TSC1 INS GRB10 HIF1A MTOR IRS1 RHEB STAT3 PMC7432147__F4 Direct regulatory function of linc-ROR in various cancers SMAD2 MTOR DUSP7 PMC3180062__F8 Schematic Model of apoptotic signaling induced by targeting EphA2 gene by siRNA in MMC CASP3 CASP9 EPHA2 FADD BAX PMC5307469__F7 Role of ATF5 in the survival of B cells during stress PDX1 ATF4 ATF5 PMC3272682__F1 Recognition of Pathogenic Nucleic Acids by Patterns Recognition Receptors and Signaling TLR7 MYD88 TLR3 ELL PMC3630382__F10 "Cell Death and Survival, Cell Cycle, Cell-to-Cell Signaling and Interaction, Cellular Movement" Network RPL26L1 FAM98A CACNB4 PHF6 MYH7B CALM1 ZNF317 KRT3 C19orf53 ALG10 MYH13 ANKRD18A PLBD2 KRT9 AAR2 PMC10744776__F4 Anticancer properties of glycyrrhizinic acid in cervical cancer models HMGB1 PDC BAD CCND1 BCL2 FADD BAX HES1 PMC11509893__F2 Possible mechanisms involved in the therapeutic effect of acacetin on liver disease TLR4 MTOR STAT3 PMC4324923__F2 Current model of NLRP3 inflammasome activation in RPE HEL-S-62p NLRP3 IL16 BRCC3 MYD88 RPE PMC3060774__F3 Chromatin remodelling during development MBD3 BPTF SOX2 PMC7575966__F1 Enzymes and intermediate products of the heme synthesis pathway FECH UROD UROS PMC4589461__F1 Negative feedback regulation of bile acid metabolism: impact on liver metabolism and diseases CYP27A1 CYP8B1 CYP7B1 FGFR4 CYP7A1 MAFG PMC8048169__F7 Graphical summary of the investigated signaling pathways during osteogenic differentiation of DFCs BMP2 GSK3B PMC11739504__F7 Summary illustration of this study TH KAT2B SAG SMO PMC10780960__F3 Comparative analysis of differentially methylated regions and differentially expressed genes in the metabolism pathways related to sink-source regulation STS EBF2 PMC12183848__F10 Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway APP BAX PMC4802898__F5 Mechanism of DQP efficacy on CHD rats COX2 LPL TG CD36 PMC3728701__F1 Musashi1 (Msi1)-dependent activation of Wnt and Notch pathways as well as of proliferation in the intestinal progenitors NUMB APC FRAT1 PMC5114345__F4 Mechanotransduction through integrins and primary cilia TRPV4 SRC PMC9667393__F2 Increased Pi availability on cellular signaling COX2 EGR1 FRS2 VEGFA FOXC2 PMC8787203__F5 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism SNRK TF HEL-S-162eP PMC6087715__F1 JAK–STAT signaling and core cancer pathways PTEN STAT3 PMC11563827__F5 Peri-implantitis involving multiple signaling pathways TLR4 WNT3A WNT1 TRAF6 MYD88 PMC9610910__F2 Protein O-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go HEL-S-11 F2 GNAL HEL107 PMC10854678__F9 Arf6 signaling pathway, the inhibitors used in this study, and a model of MuLV Gag release PLD2 CD63 MTOR ARF6 PMC4799985__F1 Microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia CD14 TLR4 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC4203530__F1 Dark side of Toll-like receptor signaling HMGB1 EGF HGF TLR9 TREM1 SRC MYD88 TGFB1 HDC STAT3 PMC6549028__F1 Emerging roles of inflammasome‐dependent cytokines in cancer development HMGB1 RHO COIL AIM2 IL1B PMC8787203__F3 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism ATG101 PMC12067419__F8 Possible underlying mechanism of AR inhibitors in the treatment of PAH HES5 NOTCH3 PMC7016711__F4 Central carbon metabolism CS ENO1 HIF1A CIT PHGDH CYP2E1 HEL-S-162eP PC FH PDK3 PSPH GLS MAL PMC3397358__F1 Viral genes and the activation of apoptosis RNASEL EIF2A BAX PMC4150436__F2 miRNAs involved in angiogenic process CD47 SUFU HGS VEGFA PTEN MTOR PIK3R2 PMC3199545__F1 Schematic diagram illustrating some of the major abnormalities related to sensitized D1R-signaling and associated to LID ARC BDNF PDYN PMC8938720__F6 Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway ANGPT2 SMAD4 ENG SMAD1 HMFT1766 DKFZp781O1323 STAT3 PMC4702938__F3 Example of the allosteric network ‘Calcium signaling pathway’ PLCG1 CHRNA7 ADCY1 SLC8A1 TNNC1 CAMK2G HTR7 MCU ATP2A1 PPIF CALM1 PLN RYR1 SPHK1 GNAS NOS2 ORAI1 MYLK STIM1 PMC9589424__F3 TSH−SPP1/TRB−TSH positive feedback loop mediates fat deposition of hepatocyte: Crosstalk between thyroid and liver INA BAD DAO MDM2 PFKFB2 PMC3739442__F1 Accelerated aging model in HIV infection ICE1 PMC6350575__F2 Differential gene expression involved in the KEGG pathway regulated by TRF treatment, i.e., (a) cell cycle, (b) p53 signalling pathway, (c) FoxO signalling pathway, (d) Wnt signalling pathway, and (e) ErbB signalling pathway ERBB2 MYC RBX1 NRG4 JUN PMC6190739__F3 DNA hypermethylation, histone demethylases and histone deacetylases effect on the metabolic enzymes expression involved in glycolysis and glutaminolysis FBP1 KDM3A MYC VHL PTEN MTOR SIRT3 SIRT4 SIRT6 KDM4C HEL-S-133P HK2 GLS PMC5501999__F2 Abnormal kynurenine pathway and atherogenesis VCAM1 LDLR TG APOE CD68 PMC6294838__F7 Signaling pathway of defensins and interleukins gene expression is regulated by PBA in porcine intestinal epithelial cells TLR4 EGFR PMC9419495__F2 Whole Exome Sequencing in Patients With Ectopic Posterior Pituitary NOTCH2 RIPPLY2 PROP1 TBX6 FGF10 SHH MESP2 LHX3 HESX1 OTX2 ROBO1 CDH2 PMC4253421__F7 LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 CCND1 LRP6 GPR49 PMC5704268__F6 Schematic representing the in-depth molecular mechanism of the neuroprotective effect of DZ BCL2 MTOR PMC6811524__F4 Canonical Wnt signaling manipulation during Rickettsia spp APC GSK3B DKK1 PMC11387478__F0 HIRI is a thorny problem after liver surgery such as liver transplantation PTGS2 MERTK PMC6811524__F3 Canonical Wnt signaling manipulation during bacterial infection of epithelial cells MMP7 APC GSK3B OLFM4 CCND1 BCL2 IL6 PMC7588841__F2 Cancer Stem Cell Niche SALL4 EGF TBX3 GSK3B ZFP42 GATA6 RHO MTOR CR1 FOXD3 SRC TCF3 SOX2 RIF1 LIF APC CRK GATA4 CDX2 KLF4 GRB2 CR2 SMAD1 DKFZp781O1323 STAT3 PMC6811524__F6 Canonical and non-canonical Wnt signaling manipulation by pathogens occupying an extracellular niche NFIB APC PMC10138520__F5 Lipid metabolic reprogramming in TNBC TWIST2 TWIST1 SMAD2 AKR1B1 PMC3913083__F1 Signaling pathways involved in the control of skeletal muscle atrophy and hypertrophy EIF3F IGF1 ALK SMAD2 ATF2 MTOR GDF11 IRS1 PMC6811524__F5 Canonical and non-canonical Wnt signaling manipulation during E ARID1B DAAM1 DAZAP2 APC GSK3B ARHA MTOR IRF2BP2 KDM6B CDC42 PMC6811524__F2 Non-canonical/Beta-catenin-independent Wnt signaling pathways DAAM1 ARHA CDC42 PMC6811524__F1 Canonical/Beta-catenin-dependent Wnt signaling MMP7 APC GSK3B MYC CCND1 PMC4189729__F1 Synthetic lethality as a therapeutic strategy for the treatment of MMR-deficient cancers MSH6 MSH3 MSH2 PMC3553670__F3 Signal transduction pathways and activation of the innate immune response TLR8 TLR7 LDLR MYD88 TLR3 TIRAP MAL PMC6594416__F2 Autophagy signaling pathway ULK1 ATG12 RIPK3 ATG101 ATG10 MTOR DKFZp686F0183 TLR4 BCL2 ATG14 FADD MLKL BAX PMC3285363__F7 Hypothetical scheme illustrating a possible mechanism of mLDL-mediated regulation of C3 expression and secretion by human macrophages HEL-S-62p CD14 TLR4 PMC6242766__F2 Animal Models to Study Bile Acid Metabolism CYP27A1 CYP8B1 CYP7B1 PMC3316934__F4 Significant differences in mRNA expression were seen for genes involved in the JNK signaling pathway between tumors arising in different CNS locations TRADD NFATC1 ATF2 LCK GRB2 MAP3K7IP1 TRAF2 CRK IRS1 FADD CRKL PMC6594416__F3 Endoplasmic reticulum (ER) stress signaling ATF4 EIF2A TRAF2 PMC3159175__F1 Multiple TYRO3-activated pathways signaling pathways converge with transcription or activation of MITF (reproduced from Mitra et al ()), an oncogenic transcription factor often dysregulated in malignant melanoma TYRO3 SOX10 PAX3 PMC87143__F6 E2F gene regulatory pathway CCNA2 MCM7 DBF4 E2F3 MCM3 MCM5 CDC20 MCM6 MCM2 CDC6 CDK2 E2F2 ORC1L RAD51 CDK4 PCNA PMC10138520__F3 Glycolysis and its relationship with other metabolic pathways in TNBC PSAT1 PHGDH PMC3402511__F4 Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain TSC2 TSC1 IGF1 PDK2 INS PTEN MTOR FOXO1 PDPK1 INSR PMC10138520__F2 Compounds secreted by adipocytes support tumor growth, angiogenesis and metastasis HGF IGF1 MMP11 VEGFA STAT3 PMC4717906__F2 Pathway and Network Analysis of Cancer Genomes PTK6 EGF LRIG1 CRIM1 EGFR SOS1 SHC1 PMC4189590__F7 Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells EGFR SRC HBEGF PMC12187804__F2 TANs promoting the growth, proliferation and metastasis of breast cancer LIN28B TLR4 MMP9 CTSC LCN2 VEGFA ALOX5 PMC4140012__F7 (Summary illustration): Three USPs regulate Imd activation or stability and downstream signalling USP34 USP2 USP36 REL PMC6521226__F5 Circadian rhythm pathway identified as one of the significant pathways by the IPA AVP VIP PMC4505489__F8 NAMPT inhibition leads to alterations of different metabolic pathways in cancer cells NAMPT FH PSPH PMC7813845__F4 BRD4 in regulating the STING1 pathway in antiviral immunity TBK1 CGAS MITA NFKB1 IRF3 BRD4 PMC7813845__F3 Role BRD4 in regulating the NLRP3 pathway in inflammation and pyroptosis NLRP3 IL18 RELA PYCARD IL1B BRD4 PMC7813845__F2 Role BRD4 in regulating the NFKB pathway in inflammation and immunity IKBKB NFKBIA CHUK TLR7 IKBKG TLR4 TLR9 NFKB1 RELA TLR1 TLR3 BRD4 PMC7025494__F1 Cytoskeletal Regulation of the Hippo pathway in Drosophila and Mammals AMOT AJUBA PMC12193713__F5 Relationship between key genes in the biosynthetic pathways of amino acids and their derivatives and the synthesis of metabolites BHMT2 PIG59 CS GPT OTC NAGS PHGDH HEL-S-5 HEL-S-162eP PDC MINPP1 PSAT1 PSPH OGDH NR1A2 ACLY DLAT SDHA ASL PMC4791423__F3 Crosstalk between the TLR signaling pathway and the Notch pathway TNF HES1 PMC9268066__F1 Progress and Prospects of Non-Canonical NFKB Signaling Pathway in the Regulation of Liver Diseases LTA TRAF3 LTB RELB CD40 TRAF2 LTBR PMC7374090__F5 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base AFP PATJ AMOT BIRC5 APC SMAD4 SCRIB RASSF6 PMC9434367__F1 Inside the Noonan “universe”: Literature review on growth, GH/IGF axis and rhGH treatment: Facts and concerns RIT1 BRAF CS SOS2 SHOC2 HRAS CBL NF1 HEL-S-80p PTPN11 GRB2 RAF1 SOS1 PMC7374090__F3 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base CDC14B PLK1 CDC23 ANAPC2 E2F5 MCM7 RBX1 SMC1A CCNB3 CDC20 MCM2 MAFK BUB1B SMC3 ATR RAD21 CDC26 PCNA ANAPC10 MAL PMC8714916__F1 Visualizing Cancer Cell Metabolic Dynamics Regulated With Aromatic Amino Acids Using DO-SRS and 2PEF Microscopy TFEB FOXO1 PMC8833689__F2 Obscure Potential of AHNAK2 AHNAK2 AHNAK PTEN PRX TF PMC5927620__F4 Metabolic pathways dysregulated in the context of disease FUOM CIT MAL PMC4504792__F6 Methylene blue-induced neuronal protective mechanism against hypoxiareoxygenation stress EPO MTOR PMC6175538__F5 Phosphoproteomic pathway analysis of heat stress induced MET signaling COX2 PAK1 HGF ATF2 GRB2 UNK PXN CRKL CDC42 STAT3 PMC8946769__F2 NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation GCLM KEAP1 GCLC SLC7A11 HEL-75 HMOX1 TXN NQO1 PMC3661706__F1 Association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer CD14 TANK TLR4 SIGIRR TRAF3 LBP TRAF6 IRF3 MYD88 TIRAP PMC2149843__F1 A pro-adhesive PPARGamma-mediated chemokine receptor switch, CCR2→CX3CR1, in atherosclerosis CCR2 CX3CR1 CX3CL1 PMC2410087__F1 Example of EGFR-mediated signaling changes, a commonly disrupted pathway in lung cancer EGF FOS MAPK7 MAPK3 NRAS SHOC2 TNK2 RAC1 HRAS GRB7 STAT1 PAK1 CTNND1 JAK1 GRB10 JUN SHC1 PAF1 STAT3 CDC42 PMC11619119__F2 Key IFN signaling pathway targets disrupted by HBV components TBK1 SOCS3 IRAK1 TRAF3 IRAK4 MYD88 ZBP1 MX2 MX1 RNASEL STAT1 ISG15 TLR8 TLR7 TLR4 SP1 STAT2 SP2 IRF7 IRF3 IFNAR2 IFNAR1 TLR3 TYK2 JAK1 SP3 SOCS1 MAVS IFIT1 PMC10273736__F5 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies TH COX2 TNF PMC6121355__F2 Multiple potential neuroprotective mechanisms in Shh signaling pathway NGF SHH SMO BDNF IL1B BAX PMC3742659__F2 Learning and memory: an emergent property of cell motility EGF SEMA3A EGFR ARHA PTEN MTOR PMC10273736__F3 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies CD14 NLK MAX TRADD HP JUND ECSIT MYD88 CDC25B TNF PMC10273736__F2 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies CD14 EGF NGF IRAK1 TRAF3 LTB TRAF6 IRAK4 MYD88 TRIM25 CNTF EDAR COX2 LTA TLR4 BCR ATM BASH CYLD LBP SYK TRAF2 LAT TIRAP PMC3264680__F3 Diagram of IGF/INSR/IGF1R signaling pathway IGF1R IGF1 IGF2 INS IGF2R PMC4410894__F3 Signaling pathways involved in pluripotency SOX2 IGF1 NODAL APC LIF GSK3B PMC12004712__F9 KEGG “Cell Adhesion Molecules” pathwayKEGG “Cell Adhesion Molecules (Immune System section)” pathway highlighting the associated a) AC and b) VC contrast DEGs TH CD99 CD6 APC CD34 ESAM SPN SELL PTPRC ITGAM PTPRO CD2 CD40 SELP COIL CD226 SELE POLI PMC4277084__F3 PPAR signalling pathway UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC5721794__F18 Working hypothesis regarding the mechanism by which SDF‐1A (stromal cell‐derived factor 1A) stimulates cell proliferation DPP4 CXCR4 CCND1 SRC PMC9101816__F5 Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway PGLYRP2 EGF COL3A1 FGF2 EGFR VCAN CYP11A1 CFL2 KIAA1608 CLU PS1TP5BP1 MAP2K1 MMP2 HP AHSG APP SRC CYP17A1 AXL PXN PMC4684904__F3 Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses DHX58 HERC6 IRF7 EIF2AK2 RTP4 ZBP1 MX1 ISG15 LGALS3BP CDKN1A PARP12 IFIH1 IFI6 PMC10978763__F3 Polyphenols and immunomodulation: a mitochondria-centered multi-modal approach NLRP3 COX2 AHR BCR MTOR STAT3 PMC9352453__F1 Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 ACE2 PMC11034561__F3 Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities HTRA1 EGF EGR1 HEY2 DLL4 EGFR PMC11034561__F2 HTRA1 can affect BrM morphology through cleavage of ECM (Fibronection) HTRA1 GDF6 CD47 SMAD2 VTN TGFB1 PMC5309409__F1 Nucleotide excision repair (NER) pathway XPC ERCC1 XPA PMC6174665__F2 IFNG/STAT1 and IL-6/STAT3 or IL-6/NF-IL6 signaling pathway STAT1 IFNG STAT3 PMC4478474__F2 Gene co-expression network of the 48 genes in the peroxisome proliferator-activated receptor pathway based on their expression values FACL4 PLIN1 HEL-S-28 CPT2 NR1C1 ACOX1 ACSL6 RXRB ACSL5 PLTP AQP7 FADS2 SLC27A1 PPARG PMC3318588__F8 Subnetwork of functional interactions of ESRP-target networks ARHGAP1 ATP2B4 MYO6 YAP1 GIT2 RAPGEF2 GUSB EPHB4 PMC7894481__F8 Scheme representing the effect of FGF2 on the activity of connexin hemichannels and consequences on ATP release and proliferation of cultured tanycytes FGFR1 NPY FGF2 PMC12102912__F9 Mechanistic illustration: ITGB3-knockdown enhances osteogenic differentiation and radiosensitizes osteosarcoma cells via JNK/c-JUN/RUNX2 pathway activation ITGB3 ITGA2B RUNX2 ITGAV BAX PMC4506991__F7 Proposed mechanisms of bilirubin modulation of TLR4 signaling TLR4 AHR CYP1A1 MYD88 PMC4426976__F1 Can we safely target the WNT pathway? GSK3B LRP5 LRP6 BCL9 PMC3022256__F2 Patterning the DV axis in Drosophila and Tribolium EGF RHO TGFA PMC8614623__F7 Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGFB1/Smad3 Signaling Pathway SMAD2 SMAD4 PMC9687800__F1 Emerging Role of YAP and the Hippo Pathway in Prostate Cancer VGLL4 LATS1 PMC4426976__F2 Can we safely target the WNT pathway? ZNRF3 RNF43 LRP5 LRP6 GPR49 PMC7432388__F2 Top two networks based on ingenuity pathway analysis (IPA) showing interactions between the controls and the case SNCA SHOX2 RUNX2 PITX2 MSC LHX3 MGA RXFP2 CACNB1 PMC11621763__F4 C-Myc/Max signaling pathway MAX MYC FADD BAX PMC8541931__F2 Molecular pathways underlying homotypic circulating tumor cell (CTC) cluster formation EGFR CD44 HIF1A CDK6 PMC6382702__F8 Clavulanic acid biosynthesis is regulated by the TCS CagRS GCA CAD PMC4975672__F1 Xenobiotic Receptor Activation: Direct vs. Indirect EGF GRIP1 EGFR PMC7465958__F2 RasGRF2 as an effector of AnxA6-mediated TNBC cell growth and motility RASGRF2 EGFR ANXA6 CDC42 PMC8575642__F1 Irisin Acts via the PGC-1A and BDNF Pathway to Improve Depression-like Behavior UCP1 BDNF FNDC5 PMC1533821__F2 Recognition of pathogens by cytosolic PRRs NOD1 IRF3 FADD PMC7016605__F1 The role of the RhoA-ROCK pathway in the pathogenesis of TBI RHO PTEN LINGO1 EPHB3 PMC4635001__F1 Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis FBL FH FES ARG1 FASN PMC2882122__F4 Selection of expression patterns and activities of members of the cadherin superfamily in cancer APC DCHS1 PCDHY CDH10 CDH2 FAT4 PMC3414384__F1 Actin cytoskeleton as a sensor and mediator of apoptosis BAD APAF1 BIK BMF FADD HRK BAX PMC12014580__F1 Cholesterol structure, synthesis, and metabolism SQLE MVD FDPS LPL LDLR APOE HMGCR PMC3092286__F1 Nonlinear signaling through the PI3K-Akt pathway PTEN RHEB PMC4176492__F2 Role of cell cycle regulators in the cellular dormancy (“intrinsic dormancy”) mechanism E2F4 APC SKP2 PMC5382276__F7 A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer CD47 NFKB1 BRD4 PMC7982813__F2 Cellular mechanisms and molecular pathways in Müllerian duct development EMX2 PAX2 WNT9B WNT7A DACH1 DMRT1 FGFR2 WNT4 GRB2 SMAD1 GATA3 TF DKFZp781O1323 PMC6545921__F5 Type I IFN plays an integral role in macrophage regulation of Mmp28 following stimulation with PAMP CD14 STAT2 IRF7 CXCL10 CCL4 MYD88 TLR3 STAT1 TLR4 TYK2 JAK1 MMP28 TIRAP PMC7719714__F2 O-GlcNAcylation induces the DNA damage response and proliferation in stem cells OGA ATM OGT ATR H2AX PMC1964795__F5 INHIBITION OF MAPK AND STIMULATION OF AKT KINASE SIGNALING PATHWAYS: TWO APPROACHES WITH THERAPEUTIC POTENTIAL IN THE TREATMENT OF NEURODEGENERATIVE DISEASE TSC2 BAD TSC1 MDM2 RHEB BAX PMC5528622__F3 Resistance to targeted therapies in melanoma IGF1R BRAF EGFR NRAS PTEN PMC3680226__F6 Analysis and Prediction of Pathways in HeLa Cells by Integrating Biological Levels of Organization with Systems-Biology Approaches ATM ATF2 ARHA RAC1 PMC7719714__F1 Cellular response to stress via O-GlcNAc-dependent epigenetic regulation OGA OGT TRIM28 EZH2 ME3 H2AX PMC7509237__F6 Model highlighting the identified dual role of GPS2 during human adipocyte differentiation ABCG1 LPL GPS2 BMP4 PMC3806458__F1 Scheme of the biochemical pathways leading to carotenoids and other terpenoids IPP PMC4366044__F4 Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics RAD1 VASP ARHH ARHA ITGA4 CRK OCA2 PXN PMC1682017__F4 Effect of increased HER2 expression on phosphorylation sites within the EGFR signaling network EGF HRG PXN PMC6280363__F3 Crosstalk between surface TLRs and dysregulated metabolic factors in diabetes TLR4 IL1B SIRT1 PMC7260123__F9 BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer IGF1 KEAP1 GRB2 MTOR PMC5020118__F1 Innate immune dysfunction in rosacea KLK5 FGF2 TRPA1 TRPV1 PMC7476100__F7 Mechanistic model to show how MEQ inhibits triple-negative breast cancer (TNBC) angiogenesis by regulating the MTA2/SerRS/VEGFA axis SIRT2 MAX VEGFA MTA2 PMC6014302__F4 GO enrichment of the highest score sub-modules RPLP0 RPS14 RPL36AL RPL26L1 RPL27 EEF1A1 EIF1AY RPL9 RPS9 EIF3G NHP2L1 ETF1 RPS5 RPS19 SSR1 RPS27A SEC61B MRPS10 RPS3 MRPL11 RPS15A SEC11A PMC3266027__F1 Activation of EGFR signaling in non-small-cell lung cancer (NSCLC) can occur via disruption of several different components at multiple levels of the pathway EGF BAD PTEN TGFA PMC7998891__F6 Molecular components of BCG-driven inflammation in bladder cancer microenvironment CXCR3 IDO1 CXCR1 COX2 CXCL10 CCR4 CXCL9 CXCL8 CCL22 PMC3561014__F2 Adjustments in root metabolism promote acclimation to deficiency CS PMC8995458__F5 Fibroblast growth factor 21 reverses high‐fat diet‐induced impairment of vascular function via the anti‐oxidative pathway in ApoE knockout mice FGF21 APOE PMC7768820__F4 Underlying mechanism of Paeonia lactiflora P ADORA2A CASP3 SLC6A3 PTGS2 CASP9 BCL2 IL6 DRD1 DRD2 TNF CASP8 PMC6990892__F13 Pathway signaling network generated from the top-ranking 100 DM promoters ADIPOR2 CHUK FYN EP300 RPS6KA1 MAPK1 LTC4S CHEK1 FXYD1 AURKB APPL1 PMC6990892__F12 Pathway signaling network generated from the top-ranking 1000 DM promoters DDR1 MAPK9 HDAC3 PIM2 GSK3B MAPK14 EZR CXCL8 CDK6 DAPP1 BCR NOTCH1 SMO FURIN CSF2RA PAX1 ABL2 ANGPT2 CTSK AREG YAP1 FES MAP3K5 AVPR2 ARHGEF25 GNAT1 PRKCB ELF3 MDFI RPS6KA1 TSHR AVP SPHK1 MEOX1 MYOD1 NME2 DLL3 HDAC5 NOD2 PIM1 ERBB4 KRT14 ATG16L1 ARHA RAC1 PRKD1 HDAC1 BCL6 LCK LYN SHC1 SKP2 MBP CAST UHMK1 MAP2K6 PAX3 SRC MYOG NOTCH2 ATG12 GPHA2 CDK5 LAMB3 BCOR CDK2 EEF2K TRADD CSF3 CSF3R HOXC6 HRH1 BTK RIPK1 PRC1 NOD1 CAV3 ATM CAMK4 CDC2 ZNF692 HMGB1 FGF2 FGFR3 SKP1 GSK3A RAB33B CHEK1 CAMK1 MYF5 CLTCL1 ITGB7 RELA FHL2 CDK3 CAMK2A APPL1 PMC8900870__F1 Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions SRC NOS1AP PANX1 PMC3724785__F7 Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1) KREMEN1 APC GSK3B LRP5 LRP6 DKK1 PMC11830738__F7 Interaction between malignant T cell and CAFs with SOX4-related mechanisms in the process TWIST1 EZH2 SOX4 STAT3 PMC7875961__F3 Horizontal pleiotropy of common genetic factors CCR5 PTK2B CSF1 PMC2819346__F1 Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance HMFN0839 PC LPA PMC6207163__F2 Modulators of Redox Metabolism in Head and Neck Cancer EGF EGFR GRB2 SRC PTEN MTOR STAT3 PMC6464042__F6 mTORC pathway regulation VPS33A FLCN GNB2 KEAP1 VPS16 LAMTOR3 SEH1L VPS18 MIOS WDR24 MTOR PDPK1 BDH2 WDR59 VPS39 LAMTOR2 ARL8B VPS41 AP3B1 VPS29 VPS35 DDIT4 MAPKAP1 MLST8 TSC2 RICTOR LCMT1 SNAPIN TSC1 LAMTOR1 TIPRL PMC2721397__F2 Key pathways in hepatocarcinogenesis and molecularly targeted agents currently under investigation in treatment of advanced HCC EGF HGF MTOR PMC8835994__F2 MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration RRN3 HEL-S-76p FOS MYC ATF1 BCL2 RAC1 JUN STAT3 PMC4622872__F1 Pathways that play important roles in melanocyte and melanoma development KIT BRAF VCAM1 TRAF1 EGFR TYRP1 CDK4 PTEN SOX10 MTOR TRAF2 CDK6 PMC6320933__F3 Regulatory network of MBP-1 PIGF MEI1 ERBB2 PMC7423166__F9 Mechanism for hepatocyte PPARA activation on BA synthesis and transport regulation CYP27A1 CYP8B1 ABCG8 ABCG5 CYP7B1 NR1C1 BAAT CYP7A1 HSD3B7 PMC12190794__F1 NcRNAs involved in the regulation of DIC TINCR PMC8750350__F3 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities HMGB1 CXCL1 GDF15 FBP1 CCL2 CD68 PMC4622872__F3 Epigenetic regulators as central components in melanoma signaling PRC1 BRAF CDK4 MTOR CDKN2A DNMT3B HDAC1 CDK6 PMC8750350__F1 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities CASP3 RIPK1 TRADD RIPK3 BCL2 TNF TRAF2 CASP8 FADD MLKL PMC8541492__F1 COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis CYP2R1 CYP27B1 PMC3504253__F1 Inactivated Wnt pathway APC LRP5 LRP6 PMC7179660__F8 Mechanism by which DDT inhibits oxidative stress and apoptosis in PC12 cells DDT SIRT1 BAX PMC8428888__F2 Preimmune Recognition and Response to Microbial Metabolites MAF KEAP1 RBX1 PMC3083967__F5 Key regulators of the mammalian target of rapamycin signaling pathway TSC2 RICTOR TSC1 PTEN MTOR SGK1 PMC8575759__F7 Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response TLR4 MYD88 TLR3 PMC8282711__F1 One Carbon Metabolism and Early Development: A Diet-Dependent Destiny CTH HEL-S-182mP ChAT SHMT1 CHDH MTHFD1 MTHFD2 PEMT HEL-S-61p MTR PC MTRR DHFR TYMS PMC8959714__F2 Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19 FURIN ACE2 TMPRSS2 PMC118037__F6 Model depicting direct and indirect regulation of clock output genes involved in conidiation PMC3504253__F2 Activated Wnt pathway APC LRP5 LRP6 PMC9348619__F6 Differentially Active and Conserved Neural Enhancers Define Two Forms of Adaptive Noncoding Evolution in Humans FAM53B CTBP2 TLE3 TBL1X GSKIP UBR5 GSK3B MYC SOX7 PYGO1 SOX4 DRAXIN SIAH1 TLE4 TEM5 RAPGEF1 GPC3 APC MAP3K7 CER1 DDX3X SKP1 JRK NLK PSEN1 STK4 BCL9L KLF4 NR1C2 hCG_2014051 PMC8773419__F1 DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders TDG DNMT3B PMC4523609__F9 Upstream negative regulators of the Hippo pathway EGFR SRC LATS1 LPA LATS2 PMC7277648__F1 Anti-aging mechanisms of metformin: From metabolic controller of longevity to the sentinel of epigenetic information OGA OGT MTOR SIRT1 PMC7986977__F5 Metabolic pathway associations of significantly different metabolites in COVID-19 IDO1 TPH1 KYNU DDC KMO TPH2 MAOA IDO2 PMC11998454__F4 Exosomes secreted by BMSCs, modified with HO-1, deliver miR-124-3p GPX4 STEAP3 PTEN PMC7705115__F4 Crosstalk between JAK2-STAT5 and hormone receptors, growth factors, inflammatory cytokines, and integrins ERBB4 SMAD2 PMC1774725__F1 Tumour necrosis factor related apoptosis inducing ligand (TRAIL) receptor signalling TRADD TRAF2 FADD PMC8197327__F1 Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour CXCR4 TRAF6 BCL2 CXCL12 BAX PMC7705115__F1 Novel components of the JAK2-STAT5 signaling pathway SOCS2 CUZD1 PMC3356660__F1 A model summarizing the results of the study in which the miR-301a molecule inhibits the PIAS3 enzyme, resulting in the promotion of the IL-6/23 receptor–STAT3 pathway and stimulation of Th17 differentiation IL23R STAT3 PMC7705115__F3 Crosstalk between the PI3K/Akt and JAK2-STAT5 signaling pathways IGF1R PIR PMC8832510__F2 Forkhead Box Family in Bone Metabolism and Diseases RUNX2 BMP2 FOXQ1 TRAF6 FOXC2 FOXO1 FOXF1 BMP4 FOXA2 FOXC1 FOXD3 ATF4 ANXA2 MSC SRC MSX2 SMAD1 PMC7912673__F1 Panel (A): Mechanisms of drug inhibition on cellular pathways TSC2 TSC1 PTEN RHEB PMC5766647__F3 Regulatory T cells are controlled by epigenetic mechanisms and T cell receptor (TCR) and interleukin-2 (IL-2) pathway MTOR ICOS FOXP3 PMC5626664__F4 Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer CTRL CDH2 CR1 PMC4446786__F1 Intracellular mechanisms activated by leucine SLC7A5 IGF1 DEPTOR IRS1 RHEB MLST8 PMC2943488__F1 Schematic of the drug- and cytokine-induced hepatocellular death signaling network, curated from literature references-, - CASP6 BAD TRADD IRAK1 INS TRAF6 MYD88 TNF MTOR IRS1 CASP3 GRB2 CASP9 UNK TYK2 TRAF2 FADD STAT3 BAX PMC5253631__F8 Exome and genome sequencing of nasopharynx cancer identifies NFKB pathway activating mutations IKBKE NRAS TRAF3 TRAF6 PTEN MTOR CDKN2A FBXW7 HLA-B HLA-A NF1 NFKBIA EP300 CYLD MSH6 PIK3CA CCND1 PMC3025434__F1 Simplified overview of the pathways involved in miRNA regulation of gene expression in addiction AGO2 RGS4 SEMA4C ATF2 STAT4 DROSHA MTOR BDNF PER2 NRP2 PMC3762715__F5 Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum APC GSK3B ARHA JUN PMC6781988__F8 Proposed mechanism of miR-125a-5p function in HCC MAP3K11 PTPN1 BAX PMC9581121__F1 Amino acid metabolism in primary bone sarcomas PSAT1 SHMT1 ASNS DHFR GLS2 PSPH ASS1 HEL-S-133P PHGDH PMC3027158__F7 Biological network of genes linked to the canonical pathway "molecular mechanisms of cancer" that were hypomethylated (fold change >1.5) in zebrafish hepatocellular carcinoma compared to healthy liver BAD APC NF1 MAX ATM HEL-S-11 SUFU MDM2 JUN MME CP RBL1 BAX PMC8833225__F4 Cathepsin family target genes in phagosomes HEL-S-62p CD14 STX7 MPO TUBB M6PR STX18 HEL-S-99n RILP TLR4 MARCO VAMP3 PIKFYVE CD36 PMC2610122__F1 Classical view of three independent Wnt signalling pathways NLK APC ARHA ROR2 PMC3027158__F8 Ingenuity network predicted for genes that were both hypomethylated and increased in expression in zebrafish HCC (shaded red) NPM1 CP PMC7716795__F1 Host genetics and infectious disease: new tools, insights and translational opportunities TBK1 MHC2TA IRAK1 IRAK2 TRAF6 MYD88 RFXAP STAT1 TAP2 IFNGR1 RFXANK SPPL2A RFX5 STAT2 IRF7 IRF9 RIPK3 IRF3 IFNAR2 TLR1 IFNAR1 TRIM25 MAP3K7IP1 TYK2 JAK1 TIRAP MAVS PMC9019694__F2 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) CCNA2 SMAD2 EGFR PTEN LATS2 KLF7 SOX9 CCND2 HMGA2 RAP2B ERBB2 CDK14 LDLR KLF2 CDK4 EIF4A3 EZH2 CDH2 PXN STAT3 PMC9019694__F5 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) UBE2C DRAM2 ATG3 FOXO3A MAP4K3 TNNC1 DVL2 TIPRL NIPBL MTOR H2AX PMC12018836__F4 Illustration of eATP signal transduction TH ECD MYC MVK PMC6137108__F3 Enriched KEGG dopaminergic synapse pathway following perinatal nicotine exposure in DA neurons PRKCA GNG13 PPP3CA GNG2 GNG7 CALML4 DRD2 PRKCH EN1 CALML3 GAB4 GNG12 PMC3641182__F2 Humanin: a harbinger of mitochondrial-derived peptides? CNTFR STAT3 BAX PMC11278003__F5 KEGGs pathway and GO molecular function (MF) analysis based on AD correlated interactors of Apaf-1 and TNFA IL10 TLR4 CRP INS IL6 TNF IL1B HEL-S-162eP PMC6137108__F4 Enriched KEGG neurotrophin signaling network following perinatal nicotine exposure in DA neurons SORT1 BAD CAMK2D HEL2 ARHGDIG SOST IRAK4 HEL-S-47e HRAS CRK SHC3 MATK CRKL RAP1A SART1 MAPK4 RELA TP73 RAF1 SOS1 IRAK3 JUN BAX PMC5297631__F1 Inflammatory role of phagocyte apoptotic pathways in rheumatic diseases APAF1 FADD PMC6667250__F3 Feed efficiency and the autophagy pathway ULK1 ATG16L1 ATG12 ATG3 ATG10 MTOR DKFZp686F0183 NBR1 PEMT MAP1LC3C KIAA0226 BCL2 UVRAG ATG14 PMC6548002__F5 Signaling pathway based on the literatures we reviewed ERBB4 DNER PTN IL34 MYC CCND1 SRC NRCAM PTEN PMC1682017__F5 Effect of HRG stimulation versus EGF stimulation in high HER2-expressing cells EGF HRG SRC PMC8469440__F3 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies TH AHR APC MTOR PMC7564545__F2 Interplay between innate immunity and hepatitis E virus (HEV) TBK1 STAT1 ISG15 STAT2 IRF7 IRF9 IRF3 TYK2 TLR3 MAVS IFIT1 PMC9056228__F2 Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD) GPX4 DHFR DHODH IPP PMC5609334__F1 NF-kB pathway EDAR BCR PMC8469440__F1 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies IDO1 HEL-S-90n KMO IDO2 PMC2203613__F10 Functional interacteome of all parietal cortex proteins EGF MAP2 MAPK8 FBP1 PTGS2 FGF2 PTGER3 HEL-S-87p GCG GSTM2 PKN2 APP JUN TGFB1 HEL-S-29 GLUD1 NEFL PMC11281655__F2 RIG-I-like receptor signaling pathway in antiviral immunity TBK1 IRF7 IRF3 MAVS BRD4 PMC9653755__F2 Current Status and Prospects of Targeted Therapy for Osteosarcoma WEE1 MTOR AURKA AURKB PMC6026538__F2 Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense NLRP3 IL18 TLR4 ABCG1 IRF3 IL6 ABCA1 APOE CD36 PMC8588809__F2 Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome TSC2 ULK1 TSC1 PC ELF3 RHO EIF4E RPS6 HIF1A EIF4B RHEB INSR PMC8777795__F3 Novel Pathway of Flavonoids Protecting against Inflammatory Bowel Disease: Modulating Enteroendocrine System CCK IGF1 DPP4 PMC4543455__F5 Canonical Wnt pathway PCK1 APC CCND1 NR1C2 TUB PMC6305104__F3 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer POR THPO PMC6305104__F2 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer FHL1 PIK3R1 SOCS2 MYC BCL2L1 MTOR AOX1 STAT1 PIM1 CCND1 STAM2 PTPN6 IRF9 GFAP HRAS PIK3R3 CREBBP CISH STAT4 GRB2 BCL2 JAK1 MCL1 RAF1 SOS1 PIK3R2 AKT3 PMC7903498__F1 Effect of Melatonin Modulation of Non-coding RNAs on Central Nervous System Disorders: An Updated Review PTEN SIRT1 PMC4105970__F5 Schematic model of specific KDAC targeting through pharmaco-logic modulation of its regulatory pathway CUEDC2 HDAC2 SP1 HDAC1 PMC8192756__F10 Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway CD14 TRAF6 MYD88 PMC9570387__F3 Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance KCNQ2 MAPK3 MAPK1 PMC9691176__F1 Vascular Endothelial Growth Factor Receptor 2: Molecular Mechanism and Therapeutic Potential in Preeclampsia Comorbidity with Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections PIGF VEGFC VEGFA VEGFB CDC42 PMC6905088__F8 Relative P450 involvement in N-dealkylation pathways of terbinafine CYP2B6 CYP2C9 CYP2C19 CYP1A2 PMC2224586__F3 HCMV regulates the expression of multiple components of the NFKB signaling pathway (see Table and Table S1 in the supplemental material for abbreviations) EGF LTA NGF BMP2 LCK RELA RELB CD40 TNF TIRAP BMP4 PMC7297305__F4 LncRNA-miRNA-mRNA network for human primed, naive and extended pluripotent stem cells WNT5B TGFA PMC6982094__F3 Exogenous GM3 and the EGFR-mediated PI3K/AKT signal pathway EGF PARP11 GAL MTOR BAX PMC6905088__F4 Metabolic model predictions for P450 catalyzed N-dealkylations CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP2A6 CYP1A2 CYP2E1 PMC3064843__F5 DNA Repair Deficiency and Neurological Disease XPC XPA LIG1 PMC8195768__F2 Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer TIFA CDC42 PMC3227781__F2 Genomic and nongenomic vascular effects of estrogen COX1 GC SRC ARHA PMC4936004__F4 LumA-R2 samples overexpress genes in the T cell receptor signaling pathway ITK FYN BCL10 LCK GRB2 CD48 CTLA4 LAT ICOS CBL PMC3068924__F4 CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data SLA BRAF APC SOST NRAS RALA TFRC RHO CCNC PS1TP5BP1 PC CDK2 JUN PMC5181566__F3 Two sets of peripheral proteins (blue and red) with the same core proteins (green) are shown CREBBP EP300 SMAD2 RELA RB1 SP1 JUN BRCA1 STAT3 SMAD9 PMC8564637__F7 MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB‐EGF/EGFR pathway EGFR CREB1 HBEGF HOXD3 PMC7783757__F7 Interrelation between 4 target metabolites and 4 concurrently mutated genes CEBPE NRF1 DGKD MGLL ARHGAP18 PLCG2 RB1 GPAM DCN A2M CHERP BCR BCLAF1 DGKE NFYC MAPK1 GPD2 ARIH2 IMMT CHGB PRCC ChAT GNA13 TCF7L2 MLX IL12RB1 ARID1A DGKA RXRA MCM6 CHKA DGKZ SPTLC3 ABCA1 CDK9 CDC42 PLCG1 RBM10 PTN ZNF263 CTCF EGFR AGK ACHE MAD2L2 CSTF2 RERE PLD2 SHBG PLA2G15 SMARCD3 SF1 RBM7 JUN NCOR2 NFYA C3orf57 RAB35 RCC1 ARHA UBE2E2 HAX1 HEL-S-87p PS1TP5BP1 GATA2 SMAD9 PEMT DGKB ARID1B CREBBP EP300 GAB2 SPTLC2 PLA2G2F PLA2G10 PMC8996108__F7 Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGFB1/Smad Signaling Pathway BLM SMAD2 STAT3 PMC8100510__F1 Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies SUFU APC GLI3 SMO PMC3099707__F10 Dual MC4R signaling model to account for “rescue” of Ay phenotype by alterations in MC4R trafficking TSG101 MGRN1 MC4R PMC4333206__F1 Notch receptors (Notch1-4) and ligands (DLL1, 3 and 4, Jagged 1-2) are expressed in tumor, normal, and endothelial cells CDK2 DLL4 PMC2715810__F7 Model of PERK pathway controlling rRNA transcription and translation in comparison to mTOR RRN3 EIF2A MTOR POLI PMC2854204__F1 TOR-dependent control of autophagy: biting the hand that feeds TSC2 TSC1 BNIP3 RHEB PMC4042557__F4 Graphical overview of the Canonical Pathway analysis SRC BDNF PMC5727168__F7 Hypoxia/IL-6/lncTCF7/TCF7/Wnt signalling axis in glioma SOX2 CCND1 IL6R STAT3 PMC6019481__F9 Regulation of the synaptic vesicle cycle pathway by SE in OVX with (CES)/without (COS) E2-replacement with respect to their non-SE counterparts (CEN and CON) CPLX1 SLC17A7 CACNA1B AP2A2 STXBP1 STX1A SNAP25 NAPA SYT1 CACNA1A SLC17A6 RIMS1 VAMP2 AP2S1 AP2M1 UNC13A PMC4259419__F2 AXL kinase as a novel target for cancer therapy EGFR GRB2 AXL GAST PMC9668530__F2 Recent advances in understanding the metabolic plasticity of ovarian cancer: A systematic review HEL-S-133P UCP2 PMC9902738__F2 Potential benefits of cinnamon to patients with diabetes, obesity, or CVDs UCP1 TRPA1 NR1C1 CD36 PMC5570638__F1 Mammalian target of rapamycin pathway TSC2 TSC1 IGF1 HIF1A PMC4148087__F7 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention ATM BRCA2 MDM2 CCND1 BRCA1 PMC4148087__F6 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention TSC2 ULK1 INHA EGFR PIK3CA SRC PTEN RHEB PMC4148087__F5 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention PTEN MTOR PMC5821844__F7 Differentially expressed artemisinin and other terpenoid biosynthetic pathway genes of A IL1A MVK IPP MVP PMC4148087__F4 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention IGF1R IGF1 PTEN PMC10131518__F2 Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma TNFSF6 CD44 VEGFA BCL2 PTPN13 CCL2 TNFRSF10A JUN TGFB1 DDIT3 ITCH STAT3 PMC4148087__F3 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention IGF1R CIC CD44 PTEN CD24 PMC2759177__F3 Survival signals generated by PI3K and PLD that target mTOR TSC2 BAD TSC1 GSK3B MDM2 PTEN RHEB PMC4148087__F2 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention NF1 KIT DUSP4 TSC1 PHLPP2 PDGFRA CDK2 PTEN RAF1 EIF4B RHEB PMC7210543__F3 Scribble complex in immune cells ZAP70 CRTAM CDC42 IFNG PMC9321239__F7 Altered RNome expression in Murine Gastrocnemius Muscle following Exposure to Jararhagin, a Metalloproteinase from Bothrops jararaca Venom CD14 EGF TRADD DAO FLNA TNF NLK FER MAX HP APP ECSIT TRAF2 APMAP PMC7215568__F2 Action of MNKs ANGPTL4 NODAL CDK2 SMAD2 GRB2 CCND1 EIF4E MTOR DEPTOR SPRY2 PMC7982081__F5 Angiocrine factors control liver function RSPO3 BMP6 BMP2 WNT9B CXCL9 GPR49 AXIN2 ARG1 PMC5548098__F1 The major pathways of Cu distribution in human cells ATP7B COX17 ATOX1 HEL-S-44 CCS PMC5964132__F4 Multiple signaling pathways are upregulated in MCF7 parathyroid hormone-related protein-overexpressing cells EREG PELO FUOM AREG BMPER AFF2 PMC5332279__F5 Schematic model of the TRIM8‐PIAS3‐STAT3 pathway that regulates glioblastoma stemness SOX2 TRIM8 STAT3 PMC11673418__F1 Simplified schematic representation of the PI3K/AKT/mTOR, RAS/RAF/MAPK, RB, and p53 pathways DKFZp781B1423 MDM2 CDK4 PTEN RB1 MTOR CDKN2A CDK6 PMC9250260__F3 p63 regulated pathway in cancer PML SOX2 APC BAX PMC8625071__F1 Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery WAS PTEN EZH2 MTOR STAT3 BAX PMC5449640__F5 Hypothetical driver pathways for BRCA carcinogenesis and progression PIK3R1 MAP3K1 MAP2K4 CDKN1B MAPK14 FGFR3 LPA FGFR2 ARID1A NF1 IFNA6 ATM BRCA2 ERBB2 PIK3CA RAD51 XB CASP8 GATA3 PMC5449640__F4 Known KEGG pathway knowledge in cancer PIK3R1 MAP3K1 MAP2K4 ERBB2 PIK3CA LPA XB FGFR2 PMC7532371__F5 Red nodes are genes of CMTgset, and the green nodes are nonoriginal/extended genes MAGED1 TMEM17 SCLT1 SBF2 MAPRE1 HSP90AB1 ATP1A1 EGFR HEL-S-101 BICD2 MLF2 MTMR2 NEFH HSPB8 SFRS18 HEL55 MTMR1 AATK DCTN5 STUB1 GRB2 SNW1 HSPA4 DCTN4 PMC7532371__F4 Biological process crosstalk among CMTgset-enriched biological processes PROC DES PMC5902451__F3 Downstream interactors affected by deleterious SAPs in CTNNB1 and KRAS APC TCF7L2 SHOC2 RAC1 RALBP1 LEF1 AXIN1 RAF1 APC2 CTNNBIP1 AXIN2 CDH2 TCF7L1 PTPRM CDC42 PMC6435474__F4 Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of ClockΔ19 mutant mice CRY2 BIRC5 TGFBR1 MYC PPP2R1A LATS1 CCND2 BMPR2 CCND1 NR1D2 YWHAG PER2 PER1 CRY1 APC BMP7 SCRIB PPP2R2B HEL-S-80p AXIN1 PPP2CA hCG_2014051 APC2 TGFB1 NR1D1 PER3 PMC9461657__F4 Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions TBK1 PINK1 ULK1 PLK1 ATM GSK3B CCND1 CDC2 MTOR CDK6 CCNE1 MYT1 PMC9367281__F4 PTEN in Epithelial–Mesenchymal Transition SMAD2 SMAD4 SRC PTEN PMC6232459__F7 HBSP regulation on PI3K/Akt signaling to affect Fas-apoptotic pathway FADD PDPK1 PMC7551260__F2 Antiviral immune response and evasion mechanism of coronaviruses TBK1 PLP2 IRF7 DPP4 TRAF3 TRAF6 IRF3 MYD88 TLR3 IL10RB IFNLR1 TLR8 TLR7 TYK2 ACE2 IRF-1 TMPRSS2 MAVS PMC2652310__F1 Anaerobic metabolic pathways in C PDC HEL-S-32 MDH2 PMC11673418__F7 Wnt/Beta-Catenin Pathway APC LRP5 LRP6 PMC11673418__F9 TGFB signaling pathway in gene expression regulation SMAD2 SMAD4 PMC9367281__F1 PTEN in Epithelial–Mesenchymal Transition TSC2 TSC1 PTEN RHEB PMC5777710__F13 CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NFKB/ iNOS pathway in STZ-induced diabetic mice CDK2 SMAD2 NOX4 PMC6121636__F1 HO-1 dependent pathway activated in neurons and in the different glial cells GDNF BDNF BACH1 PMC10926848__F4 BCR signaling pathway and BCR-associated CXCR4 signaling in CLL TSC2 TSC1 BCR CXCR4 LYN SYK PLCG2 PTEN CXCL12 RHEB CD19 PMC4187706__F9 Schematic model showing AngII regulation of HSD3B1 in H295R cells HSD3B1 HSD3B2 CYP11B2 PMC8855721__F7 Potential mechanism of the effects of HF-MSCs in the treatment of LC ACTA2 SMAD2 SMAD4 PMC11074996__F1 The multi-modular engineering and efflux strategies for lycopene synthesis in Saccharomyces cerevisiae ERG IDI1 IPP PMC5146274__F8 Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis ITGB3 POSTN ITGAV PMC12145652__F7 GETV Nsp2 inhibiting the RLR signalling pathway by regulating IRF3 activation TBK1 KPNA4 RIGI IRF3 KPNA3 MAVS PMC6127653__F2 Role of p21-activated kinases in Kras-driven oncogenic signalling pathways RAC1 CRK ADM CDC42 PMC3903702__F1 EZH2 takes the stage when BRCA1 loses EZH2 ME3 BRCA1 SUZ12 EED PMC140507__F1 The PI 3-kinase pathway by RNAi PTEN PMC6399846__F2 KIT mutant GISTs have enrichment for KEGG cell cycle pathway (p = 0.0007) and spliceosome pathway (p = 0.0008) using STRING v10 clustering of significantly somatic mutated genes (p < 0.003) KIT USF1 RBMXL3 SPDYE1 FRG1 QRICH2 NRG1 FBXO2 RB1 AAAS SF3A2 CLINT1 EDAR TCOF1 CLK1 CDC27 HECW1 RBMX U2AF2 MSH3 JUN PMC8019700__F2 Human rhinoviruse (HRV) replication and inflammatory response IL16 LDLR IL6 CDHR3 PMC4747800__F1 PI3K/AKT/mTOR pathway and cellular processes controlled by downstream signaling TSC2 RICTOR BAD PHLPP2 EBP GSK3B CCND1 PTEN MTOR FOXO1 PHLPP1 PMC7077606__F1 SFRP5 at the crossroad between obesity, T2DM and CHD ROR2 RHO SFRP5 PMC8158769__F1 Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease HEL-S-62p C4A PMC9898571__F7 Osteoarthritis: pathogenic signaling pathways and therapeutic targets RUNX2 SMAD2 TGFBR1 TGFBR2 SMAD4 SMAD1 DKFZp781O1323 PMC12058719__F2 Osteoporosis (OP) regulation by protein arginine methyltransferases (PRMTs) (A)PRMT1 influences bone formation and resorption through the BMP2/Smad and other pathways, thereby mitigating OP ME2 RSAD2 CXCL10 MSX1 TRAF6 DDR2 SMAD9 PRMT1 PRMT7 PRMT3 MSC PRMT6 SMAD1 DKFZp781O1323 PMC9898571__F3 Osteoarthritis: pathogenic signaling pathways and therapeutic targets RUNX2 LRP5 LRP6 FRZB PMC9898571__F6 Osteoarthritis: pathogenic signaling pathways and therapeutic targets ADAMTS4 ADAMTS5 RUNX2 VEGFA STAT3 PMC9327256__F7 Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H2O2 enhances their ability to treat intervertebral disc degeneration HEL-S-8a CCND1 LATS1 LATS2 BAX PMC6186824__F2 BAFFR-induced intracellular signaling BTK BCR BASH TRAF3 RELB SYK PLCG2 EIF4E MTOR TRAF2 SKP2 CD19 PMC8535999__F1 Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications NRP1 PALS1 ACE2 PMC5094909__F1 Energy Metabolism and Inflammation in Brain Aging and Alzheimer’s Disease IGF1 GRB2 INS PMC5964014__F7 Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury SARM1 JUN BAX PMC7971856__F7 Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol CGAS TLR4 SHARPIN MAVS PMC8387591__F1 Mouse Models of Germinal Center Derived B-Cell Lymphomas HEL-S-62p TH TNFRSF14 MEF2B MYC GNA13 MYD88 CD79B CCND3 FOXO1 TET2 BCL6 CREBBP BCL2 EZH2 MLL2 PMC8834116__F7 Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway ACTA2 HEL113 COL1A1 PMC7485387__F3 FGF23 signaling in the kidney EGR1 FGF23 FGFR1 TRPV5 CYP24A1 CYP27B1 PMC6705128__F2 DUBs regulating TCR signaling USP15 CYLD OTUD7B ZAP70 USP9X MDM2 LAT USP18 PMC5449757__F1 Schematic depiction of uPAR/suPARAvB3 integrin signaling at the glomerular filtration level in health and diabetic disease IGF1 VTN PMC7485387__F1 FGF23 regulation in osteocytes PTH1R EGR1 IGF1R ALK FGF2 TRAF6 PTH MYD88 DMP1 FOXO1 TLR4 FGF23 FGFR1 NR1i1 HEL-S-11 IL1B ORAI1 STAT3 PMC5725996__F1 Summary diagram of energy metabolism pathway CS PCK1 FBP1 LHPP ATP6V0A4 HEL-S-87p ATP8 NDUFV3 PC LDHD PKLR NDUFA9 ENO2 ND5 NDUFA10 OGDH PFKP HEL-S-133P PMC2997002__F2 Gene list involved in TLR pathway generated by KEGG MYC PMC2997002__F3 MAPK signaling pathways generated by GenMAPP CD14 PRKCE IKBKG SET BRAF SOS2 TES GCK CASP2 GNAT2 JUND RAN PRKCH BDNF PMC5858821__F1 Illustration of self-assembly and accumulation of redox-sensitive PTX-HSV nanoparticles in tumor tissues and their intracellular trafficking pathway NHS CD44 PMC3792586__F1 TNF signalling pathway TRADD MADD TNF TRAF2 FADD PMC7881277__F1 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology COX2 BAD CASP9 SPHK2 PMC8446557__F3 EGFR‐mutated stage IV non‐small cell lung cancer: What is the role of radiotherapy combined with TKI? ATM ERBB2 ERBB3 GSK3B RAD50 RAD51 MRE11A BRCA1 PCNA PMC7710791__F2 Pathway 1—management of a previously healthy child/adolescent, suspected, or probable case of COVID-19 FER SI HEL113 ACAN POR PMC7881277__F3 Apoptosis signaling pathway and the predicted gene targets of miR-410 (IL1R, XIAP, NTRK1, PPP3CA, PRKACB3) and miR-19a (IL1R1, PIK3R3, MAP3K14, PRKACB3), which are involved in cytokine–cytokine receptor interaction BAD TRADD ATM MYD88 FADD BAX PMC7530066__F9 Insulin-like growth factor 1-Receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis IGF1R IGF1 ATF4 MTOR PMC7881277__F2 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology HEL-S-62p F10 F2R THBD F8 F9 PROC C4A PLAT C9 A2M F2 F3 C7 VWF F11 TFPI PLAUR PLG KLKB1 CPB2 CD59 F5 C6 F7 CR2 PMC5979464__F3 Beta2-adrenergic receptor signal transduction TH GRK1 ADRBK1 PMC7881277__F4 Neurodegenerative disorders signaling pathway and the predicted gene targets of miR-19a (SOD1) and miR-126, which are involved in the insulin signaling pathway SNCA HEL-S-89n CASP6 BAD LRRK2 GFAP NEFH BCL2L1 CASP3 PINK1 CREBBP APLP1 HEL-S-67p NGFR APBA1 GRB2 APP HEL-S-44 BCL2 HEL-117 CASP8 APOE BAX PMC7816079__F5 Saponin biosynthetic pathway in P. notoginseng and expression profiles of key enzyme genes.The genes in the green box are the UGT genes identified in this study SST MVD DST MVK IPP GGPS1 PMC5979464__F1 The major neuroendocrine and autonomic pathways that regulate secondary immune organs are illustrated CORT CRH PMC6817488__F5 AA-induced vasorelaxation and relationship to aldehyde metabolism GC ALDH2 PMC5979464__F4 Canonical B2-adrenergic receptor (B2-AR) signaling response, the anti-inflammatory cytokine profile mediated by protein kinase A (PKA), and the major anti-inflammatory cellular mediators of the resulting anti-inflammatory immune response GRK1 ADRBK1 PMC10941343__F12 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach ROCK2 EGF VCAM1 EGFR MDM2 SRC MAPK1 PMC2674225__F2 Repression of TGFB-RII and abrogated signaling through the Smad pathway STAT1 EGF SMAD2 TGFBR1 SMAD4 ARHA JAK1 IFNG PMC7479443__F1 De novo purine synthesis pathway ADSL PAICS APRT PMC8283767__F2 Non-coding RNAs in Alzheimer’s Disease: From Regulated Mechanism to Therapeutic Targets and Diagnostic Biomarkers IGF1 EGFR APP SPHK1 MCL1 BDNF RAD18 PMC8584118__F3 Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections NLRC4 NLRP1 NLRP12 NLRX1 NLRP6 IRF3 DHX15 NOD2 TLR3 GSDMD NLRP3 IL18 TLR7 NOD1 IL1B PMC3254618__F3 Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome CORT BAD HEL-S-11 PMC6884345__F3 TGFB signaling in the colonic mucosa SMAD2 SMAD4 PMC4411486__F3 Predicted co-regulation of genes in the MAPK signaling pathway targeted by downregulated miRNAs in BAT during torpor CD14 DAO MAX FOS GRB2 PMC6122627__F5 The pathways being affected by MDD and by treatments KEAP1 MYD88 DUSP2 PMC4411486__F2 Predicted co-regulation of genes in the MAPK signaling pathway targeted by the downregulated miRNAs in WAT during torpor CD14 MOS DAO MAX GCK KIN JUN PMC4411486__F4 Predicted co-regulation of genes in the TGFB signaling pathway targeted by upregulated miRNAs in WAT during torpor NODAL SMAD4 SKP1 ARHA INHBA IFNG PMC6071023__F2 Resistance to EGFR tyrosine kinase inhibitors TSC2 EGF TSC1 EGFR GATA6 SMO MTOR RHEB WNT7B PMC7105297__F1 Genome-wide CRISPR/Cas9 screen for positive regulators of SL biosynthesis SPTLC1 GOLPH3 ARPC4 SPTSSA AHR ARPC3 A4GALT UGCG TM9SF2 NCKAP1 TMEM165 SPTLC2 ACTR3 KDSR CERS2 ACTR2 PMC5867104__F2 Wnt/beta‐catenin pathway‐related lncRNAs and their interactions in cancers FZD8 PMC5867104__F1 Wnt/B‐catenin signalling pathway APC GSK3B LRP5 LRP6 PMC8946235__F1 Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal Cancer PALB2 MAX BRCA2 MSH6 SSB RAD51 PARP1 ERCC1 MSH2 BRCA1 PCNA PMS2 PMC12111560__F5 Expression profile of candidate genes involved in the organic acid metabolic pathway in pomegranate ME1 CS PMC8048608__F3 UPR pathway highlighting gene‐expression differences between the low‐risk and high‐risk PSC clusters SEL1L CANX OS9 AMFR ATF4 EIF2A TRAF3 HEL-S-99n BCL2 VCP TRAF2 XBP1 PMC9393521__F1 Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently? BTK BCR SYK MTOR PMC2945029__F6 Pathways and networks related to chondrocyte proteins identified by proteomics as altered by GS and/or CS HEL-S-102 ANXA1 HEL-S-269 ANXA2 HEL-S-87p HEL-S-7 PGAM1 PS1TP5BP1 HEL-S-22 HEL-S-68p PMC9699619__F2 Renin–Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes ACE2 PMC5877752__F1 Homocysteine (Hcy) metabolic pathway VIT PMC2730119__F3 Scheme showing the role of different signaling pathways in mediating the effect of high K intake on ROMK and BK channels in the CCD WNK1 WNK4 SGK1 PMC4167409__F1 Androgen biosynthesis in prostate cancer cells HSD3B1 AKR1C1 AKR1C2 CYP17A1 HSD17B6 PMC6298973__F8 Proposed TLR 2, 5, 8 signaling pathway IRF7 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 TIRAP PMC7064973__F2 Theorised DIS3L2 and let‐7 pathway mediating gastrointestinal nematode (GIN) resistance IL10 DIS3L2 TUT4 LIN28A TUT7 PMC2932783__F1 Targeting of signaling pathways by arsenic trioxide in chronic lymphocytic leukemia cells PTEN MTOR PMC4028840__F1 PI3K/Akt/mTOR signaling pathway ] TSC2 TSC1 PTEN IRS1 RHEB PMC7203449__F4 Visualization of Gene Ontology (GO) enrichment profiles from DEGs using Cytoscape software based on network analysis of ClueGO/CluePedia inferred from MCODE cluster 1 (A) and cluster 2 (B) MAPK9 MARCKS E2F6 APC VEGFA NCF4 CHEK1 CDK6 FYN E2F7 RRM2 TYMS MPEG1 CP PMC5141617__F4 Conflict resolution in the genome: how transcription and replication make it work MRC1 INO80 SETX MAF1 ATR BRCA1 PMC4085491__F1 ELF4 in type I IFN signaling TBK1 IRF7 IRF3 ELF4 MAVS PMC10121353__F8 Main nodes of AGE-RAGE signaling pathway MCAM PC BAGE APP PMC8198876__F1 Targeted Therapeutic Approach Based on Understanding of Aberrant Molecular Pathways Leading to Leukemic Proliferation in Patients with Acute Myeloid Leukemia CD33 SUFU SMO MTOR TET2 BAX PMC8758495__F3 Amyloidogenic vs non-amyloidogenic pathway BACE1 ADAM9 APP PMC5727901__F1 Cyclin–CDK complexes and the cyclin D–CDK4/6–p16–Rb pathway in the cell cycleThe cell cycle is regulated by cyclins and checkpoints, with different cyclins (and cyclin–CDK combinations) and checkpoints acting at phase transition of the cell cycle CDK2 CDK4 CDC2 MTOR CDK6 PMC7046305__F7 Anti‐tumour mechanism of Tan‐Ⅰ MTOR BAX PMC4898689__F8 Integrated Analysis of the Roles of Long Noncoding RNA and Coding RNA Expression in Sheep (Ovis aries) Skin during Initiation of Secondary Hair Follicle UBC UCP1 HEL-S-28 LPL PMC8284746__F2 Metabolic Control of Mouse and Human Astrocytes CCL2 TNF MAVS PMC4436984__F2 Key signaling regulation of autophagy in the heart ULK1 IRS1 PMC8814460__F2 Inflammation and Myeloid Cells in Cancer Progression and Metastasis CXCL1 CCL8 CD47 SOCS3 CCL26 CXCL5 CXCL8 IL8RB CXCL2 CCL7 CCL5 CCL2 CXCR4 CXCL17 CXCL12 ARG1 STAT3 PMC8814460__F1 Inflammation and Myeloid Cells in Cancer Progression and Metastasis CXCL1 CD33 MDC1 IL8RB CXCL2 TNF PDC CCL24 CD163 IL33 CCL17 CD80 CCL18 CXCL12 CD1C CCL3 PMC8919643__F4 Untargeted metabolomics analysis of esophageal squamous cell cancer progression PTDSS1 PC LPCAT1 PMC3321553__F2 Coregulation of gene transcription by p53 and Smad complexes SMAD2 MDM2 SMAD4 PMC7290932__F5 Models for release of the Xenopus oocyte prophase block: probable cooperation between several receptors and downstream pathways IGF1R MOS IGF1 PMC9661388__F6 Basal diet composition contributes to differential performance, intestinal health, and immunological responses to a microalgae-based feed ingredient in broiler chickens ACSL5 FACL4 PGM2 AGPAT3 ACACA BMX PRKAG2 CROT GAL IDH3B AGL PMC6664200__F3 Type I-IV mechanisms which aberrantly activate hedgehog pathway in cancer PTCH1 SHH SMO PMC6664200__F1 Diagrammatic representation of human hedgehog signaling pathway KIF7 SUFU PTCH1 GLI3 SHH SMO PMC7290932__F1 Diverse signalling pathways initiated by maturation initiation hormones (MIHs) lead to a universal biochemical core, activating maturation promoting factor (MPF) MOS WEE1 ARPP19 CDC2 MYT1 PMC2175514__F5 Transcription regulatory network indicates utilization of various transcription factors following activation of TLR7 IRF7 IRAK1 IRAK2 CD44 IRAK4 CCL5 ISG15 COX2 TLR7 TRAF1 STAT4 CCR7 TYK2 PMC6008129__F1 Potential mitochondrial derangements that may be present in pulmonary hypertension are many and varied TRPC3 UCP2 STAT3 PMC2175514__F9 Protein regulatory network indicates importance of ISGylation pathway in TLR7-mediated activation of pDC STAT1 FGFR1 MAPK3 LYN TRAF6 IRF3 JAK1 SIAH2 UBE2D2 TCF4 USP18 PMC9705782__F1 Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome AGO1 AGO2 AGO4 PMC6233321__F1 Ceramide pools and their metabolic connection CERS3 LASS1 CERS5 CERK SMS CERS2 CERS6 PMC3486512__F3 Network analysis of the host factors found to be associated with the extremities of the murine norovirus genome HNRNPAB HSP90AB1 EEF1A1 EIF2AK2 TLN1 RPL23A EEF1G PABPC1 HNRNPD TFG KHSRP PCBP1 HNRNPA2B1 PURB RPL26 KPNA3 PTPN6 DDX5 HNRNPF FASN CCT6A HNRNPR ANXA1 YBX1 RTN4 PTBP1 FARSLA EEF2 DDX3X PDCD6IP FUS PABPC4 DDX39B RSL1D1 GNL3 HNRNPUL2 HEL-S-100n NCF1 HEL-S-72p CSDE1 PMC6658873__F1 Synergistic effect of three combined strategies by targeting complement/C3aR /C5aR1/IL-10 pathway and other treatment modalities C5AR1 LAG3 PMC4164812__F1 BRAF inhibitors on melanoma and immune cells BRAF CCL2 PMC9134690__F3 Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease SALL4 UBE2M GRIP1 RNMT SNRPN POLL CHD4 CEBPB PRPF31 PSMD10 DDX5 PRPF8 PSMB8 PSMC1 SNRNP200 POLI EHMT1 USF1 POLR2K POLR2G SNRPF PSMA2 NEDD8 HNRNPA0 PDIA2 PBX1 MED18 DDIT3 EED PCF11 SNRPE AXIN1 ATN1 RAN PMC9091820__F2 Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons TBK1 CGAS TLR9 IRAK1 TRAF3 MYD88 IFITM1 MX2 MX1 STAT1 TLR8 OAS1 OAS2 OAS3 TLR7 TLR4 STAT2 IRF7 IRF8 IRF9 IRF3 IFNAR2 IFNAR1 TLR3 BCL2 TYK2 SOCS1 MAVS PMC3951427__F12 New miRNA Profiles Accurately Distinguish Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas from the Normal Kidney PERP MADD MYC EED PMC12025219__F3 Changes in bone metabolism caused by cold environment FGF21 UCP1 RUNX2 SOST PMC4567404__F1 A worm of one’s own: how helminths modulate host adipose tissue function and metabolism IL33 PMC6862705__F5 SPRY-altered signaling network profiles in mammary stromal fibroblasts ABL2 MAPK9 PHLPP2 MAP2K4 MAPK8 HEL-S-28 EGFR MAP2K2 ARHA EIF4EBP1 CRK TSC2 ERBB2 PIKFYVE SRC PPP2R5E HEL114 RPS6 JUN PXN PMC1756898__F1 Unraveling the Genetics of Human Obesity POMC NPY AgRP MC4R GHR LEPR BDNF PMC11814453__F4 The mechanism by which sodium channel inhibition exerts anti-tumor effects SRC IRF3 MTOR PMC11814453__F2 High salt or sodium ions on immune cells in the tumor microenvironment BATF3 NLRP3 LTA TLR4 NLRC4 NOS2 MTOR ARG1 STAT3 PMC6770497__F8 Key metabolic pathway and regulatory network in mutant ptsd1 GDA CAD AMT PMC9141700__F3 Metabolite and Gene Expression Analysis Underlying Temporal and Spatial Accumulation of Pentacyclic Triterpenoids in Jujube MVD MVK IPP PMC5885413__F3 LncRNAs regulate Rho/ROCK signaling in cancer metastasis TIAM1 MMP2 ARHA RAC1 CDC42 PMC5081730__F1 Epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway EREG BTC AREG EGFR BMP15 PMC3410320__F1 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell EGF IGF1 NGF PLG GDNF BDNF PCNA PMC10866157__F6 Schematic diagram depicting the mechanisms of 5-aza-dC treatment in inhibiting choroidal neovascularization in a laser-induced mouse model LEF1 APC NOTUM AXIN1 LRP5 CCND1 LRP6 AXIN2 PMC5864536__F1 Estradiol and the Control of Feeding Behavior CCK POMC NPY CRH AgRP TRH NTS PMC2650609__F6 Top network of upregulated genes in quadriceps muscles of COPD patients, compared with control subjects G0S2 FOXO3A FHL3 KLF9 HEL113 SH3BP5 SLC16A3 FOXO1 UCP2 ALDH2 PMC4393798__F3 Overcoming T cell exhaustion in infection and cancer APC LCK ZAP70 BATF PMC9369298__F3 diaPASEF Proteomics and Feature Selection for the Description of Sputum Proteome Profiles in a Cohort of Different Subtypes of Lung Cancer Patients and Controls HEL-S-62p F10 CS PLG F8 CR1 CPB2 CD59 A2M F2 FH F3 VWF F11 F7 CR2 PMC5457689__F6 Apoptosis pathway ATF4 CAD HTRA2 PMC3928643__F4 IL-12 centred network analysis TLR4 IL12A TGFB1 IL12B IFNG PMC3928643__F3 IFNA/B and IL-4 centred pathway analysis IL2RG CD40 GIP IL4 IFNG CCL3 PMC9704719__F6 Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation SLC7A5 AHR PMC7004522__F8 Working model shows that MET inhibitor inhibited the positive feedback loop between high STMN1 hepatocellular carcinoma (HCC) cells and hepatic stellate cells (HSC) HGF PMC11674327__F1 Extra-ribosomal functions of two RPs activating the NF-kB pathway during viral infection RPL13 SMARCA5 RPSA PMC5485730__F2 Interferon (IFN) type 1 signaling; regulation by methylation STAT1 PRMT1 JMJD6 STAT2 IRF9 PIAS1 TYK2 IFNAR2 JAK1 IFNAR1 PMC11933101__F1 Pyruvate synthesis pathway XK XDH PMC6331187__F8 The mechanism of celastrol in TGFB/Smad signaling pathway SMAD2 TGFBR1 TGFBR2 SMAD4 PMC5347564__F1 Hippo signaling pathway is the only pathway enriched with up-regulated DEGs EGFR APP CIT PMC9119001__F3 Metabolic engineering of microorganisms for L-alanine production AIDA PMC5407986__F2 Mitochondrial Control of Innate Immunity and Inflammation TBK1 UBXN1 TANK TRADD IRF7 NLRX1 TRAF3 TRAF6 IRF3 TRIM14 PC SMURF2 HEL-S-276 PCBP1 TRAF2 MAVS PMC5407986__F1 Mitochondrial Control of Innate Immunity and Inflammation STAT1 STAT2 IRF7 IRF3 IFNAR1 MAVS PMC3206369__F1 Primary phosphatases function as tumor suppressors and their signaling pathways TSC2 PI3 PTEN INPP4B MTOR RHEB PMC6321995__F2 Therapeutic strategy for downregulation of excess inflammatory mucus to normal physiological mucus levels, using a small-molecule kinase inhibitor of MAPK13 MAPK13 CLCA1 MUC5AC APC PMC7646980__F10 Anti-inflammatory effects of BBR on LPS-induced inflammation via suppression of the TLR4/NFKB and MAPK/AP-1 pathways CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TNF MAP3K7IP1 COX2 TLR4 SIGIRR ECSIT IL1B MAL PMC8739177__F1 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF SPG20 CREM POR PMC8739177__F3 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF KIT ADRA2C NR3A2 CYP1B1 ACACA MMP9 IL6 HSD17B2 TNF CYP1A2 RET AHR KDR SHBG MMP2 CYP2C19 CYP3A4 ABCC1 TYMS IL2 CYP17A1 BAX PMC5996447__F8 Hei-Gu-Teng Zhuifenghuoluo granule and the IL-12 signaling pathway IL16 STAT4 IL1B IL12RB1 PMC9219782__F1 Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men TBK1 TRADD RIPK3 TNF MAP3K7IP1 GSDMD CASP3 RIPK1 CYLD TRAF2 OTULIN FADD MLKL PMC4470863__F2 Commitment and maintenance of gonadal cell fate RSPO1 WNT4 FOXI2 FOXL2 SOX9 FGF9 SRY PMC8739177__F4 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF KDR AHR SHBG NR3A2 MMP2 CYP3A4 ERBB2 ACACA MMP9 CYP1A1 IL6 TNF PMC4112160__F2 Surviving Change: The Metabolic Journey of Hematopoietic Stem Cells TSC2 TSC1 PTEN MTOR PMC5412370__F1 Specific elements of the canonical pathway for modulation of gene expression that are activated after 15 min of exposure of U118MG cells to 25 µM of PK 11195, as uncovered by “Regulator Effects” analytic (IPA®) EGF SH2D2A BAD NGF FOXO3A WNK1 LIF EGFR MYC SRC PMC3247990__F8 Post-induction repression of IFNB expression by YY1 in TLR3 signaling pathway TBK1 IRF7 RELB YY1 IRF3 TLR3 PMC6325472__F1 PI3K pathway activation and cell-cycle in tumor cells CSH2 PI3 GSK3B CDK4 PTEN CDK6 PMC2835907__F3 Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands EGF IGF1R IGF1 EGFR FGF10 SHH CCND1 FGF7 PMC2735462__F3 Ubiquitin in NFKB Signaling TANK TRADD CYLD IRF3 MAVS PMC3148288__F1 ERM proteins are scaffolds for cAMP signaling pathways CSK LCK ARF6 PMC9092946__F1 Endoplasmic Reticulum Stress and Its Role in Homeostasis and Immunity of Central and Peripheral Neurons NLRP3 ATF4 EIF2A MYC IRF3 HIF1A IL1B GSDMD PMC3109512__F3 Proposed role of CnPlc1 in pathogenicity-related signaling in C CS GPR4 NRG1 PMC7319438__F1 SPEED2 application We manually selected pathway-specific perturbation experiments and estimated their pathway-relevance PHLDA2 IER2 HBEGF MCL1 PMC3922094__F2 Pancreatic cancer pathway diagram EGF PTEN TGFA PMC9682072__F3 Viral tropism for the testis and sexual transmission ISG15 CGAS TLR5 TLR4 CXCL10 IRF3 MYD88 TLR3 SOCS1 MX1 PMC8558658__F7 Hey1 promotes migration and invasion of melanoma cells via GRB2/PI3K/AKT signaling cascade GRB2 PMC6983753__F5 Likely pathogenic mutations restricted in the metastases affect DNA methylation and transcriptional repression signaling pathway RBBP4 CHD4 DNMT3B MTA2 CHD3 MTA3 MBD3 SAP18 SAP130 RBBP7 MBD2 SIN3A SAP30 PMC6803376__F5 In the presence of the Ter mutation in Dnd1, members of mTOR, Hippo and Bmp/Nodal pathways have altered expression, with some transcripts indicated as direct targets of DND1 AMOT NODAL CRIPTO SMAD4 PTEN MTOR RPTOR RHEB TSC2 RICTOR TSC1 YWHAG SMAD1 SGK1 AKT3 PMC1557712__F2 Molecular control of alveolar morphogenesis SOCS2 ERBB4 ELF5 PGR WNT4 IGF2 CEND1 TGFB1 TF SOCS1 EIF5 PMC2346559__F1 An Allosteric Mechanism for Switching between Parallel Tracks in Mammalian Sulfur Metabolism HEL-S-61p HEL-S-182mP MGA PMC9630750__F2 Drosophila melanogaster as a model to study innate immune memory ATF2 MYD88 REL FADD PMC2716801__F1 Schematic illustration of the Warburg effect in tumor cells and in early asymptomatic endothelial cell dysfunction TIGAR ECHS1 PMC6034857__F5 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) CD14 STX7 TLR4 MPO TUBB M6PR VAMP3 STX18 HEL-S-99n MARCOL RILP CD36 PMC8705789__F3 The Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries PTEN CTLA4 MTOR PMC10308199__F3 Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes CDO1 SUOX pcap PMC4163898__F1 Stress-induced premature senescence (SIPS) signaling pathway ATM MDM2 CDK4 ATR CDK6 PMC10380929__F3 PINNet: a deep neural network with pathway prior knowledge for Alzheimer's disease MYB FLNA MYC ALDH3A2 FGFR2 GGPS1 MDH2 GOT2 DGKE SMO SNCA SOS2 PAFAH1B1 HLA-DOB AOC2 FGF13 TCF7L2 PLCB1 HLA-A EDN1 LEP PRKCB CRH NR1C2 ABCA1 PLEK HLA-DMB MARS2 NOD2 CLU IL18 DDC APP THBS1 TCF7L1 ARAF CTH HK3 KIT SLC17A7 ANXA1 ACVR1 LRRK2 ARHA NFATC3 BCL6 IKBKB ANGPT1 EP300 HLA-DQA1 NR4A3 LYN ADA CD40 SYK GNAS HLA-E RPA3 PPP3CA P2RX7 PRKAA1 POR BMPR2 FZD2 SRC HDAC2 HK2 GHSR HEL-S-28 CACNB3 HRAS CDK2 ATP2A2 CDC42 ITPR2 PLCB3 PRKCE HGF ATP1A1 PFKM RARA JUP PTPRG ATM PTPN11 EPHA4 BAX NFE2L2 MMP9 PFKL GATA2 MAP2K1 NFKB1 RELA PIK3CA RAF1 CYCS PMC8261290__F3 Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti MYD88 NPC2 HEL-S-5 PMC10992626__F2 Simplified illustration showing key pathways involved in disc degeneration ADAMTS4 ADAMTS5 SDC4 ACAN TNF STAT3 PMC9221885__F1 New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer’s Disease and Its Potential for Therapeutic Intervention NLRP3 CGAS IRF3 MTOR APOE PMC8970588__F8 Simplified model showing how availability of the dedicated chaperone Rrb1 or Acl4 and the here uncovered regulatory network cooperate to balance Rpl3 and Rpl4 expression by co-translationally regulating RPL3 and RPL4 mRNA levels CA14 RPL4 RPL3 PMC3103989__F1 Endocrine, paracrine and autocrine regulation of the IGF-1R pathway and therapeutic strategies for its disruption IGF1R SHE PTEN MTOR IGF2R GHRH PMC8656811__F3 Genome Instability in Multiple Myeloma: Facts and Factors HMGB1 BCR BACH2 PAX5 RAG1 XBP1 IRF4 RAG2 FOXO1 BCL6 PMC10037588__F6 Reassessing the Abundance of miRNAs in the Human Pancreas and Rodent Cell Lines and Its Implication TSC2 BAD GRB2 INS EIF4E POC1A FOXO1 RHEB INSR CBL PMC6071487__F2 Interleukin 6 (IL-6) receptor-mediated signaling pathway and an IL-6 inhibitor, the humanized anti-IL-6 receptor antibody tocilizumab SOCS3 CD5 SOCS1 STAT3 PMC6071487__F3 Arid5a stabilizes interleukin 6 (IL-6) and Stat3 messenger RNAs (mRNAs) TLR4 PYY MYD88 ARID5A STAT3 PMC9623116__F4 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential BTK BCR BASH SYK MCU ORAI1 STIM1 BAX PMC4484611__F6 Cell adhesion molecules (CAMs) pathway CD58 CD9 CD99 CD6 ICAM2 ESAM SELL MPZ CD2 CDH2 PTPRM ICOS SELE APC NRCAM CTLA4 PTPRC ITGAM CNTN2 CDH4 CD22 PTPRE CD40 CD80 CD226 JAM2 ELL CD36 PMC11694080__F7 Fluxes of glycolysis, pentose phosphate, and TCA cycle pathways in hMφ treated with DETA‐NO and CK PC RP1 GLDC RPE ADM PMC4872639__F8 Gq-dependent signalling by the lysophosphatidic acid receptor LPA3 in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA ARHA RHO LPA PMC3954954__F6 Tissue Factor Inflammatory Response Regulated by Promoter Genotype and p38 MAPK in Neonatal vs. Adult Microvascular Endothelial Cells EGR1 TRADD SP1 TF STAT3 PMC8465200__F1 Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review CASR CYP24A1 PTH RXRA RXRB CYP27A1 NR1i1 CYP3A4 CYP2R1 DHCR7 CUBN DBP CYP27B1 PMC7216841__F1 Latency reversing agents induce HIV‐1 provirus replication by diverse mechanisms CS MEPCE LARP7 PTEN CDK9 BRD4 PMC3406727__F1 Simplified schematic drawing of metabolic pathways in Chlamydomonas reinhardtii (adapted from Ref HEL-S-62p C6 PMC5927619__F2 Pathway diagram for IL-2 family signaling showing the increase in detail level as zoom level increases SRC SYK MATK RHOU PMC5927619__F1 Enhanced high-level diagram (EHLD) for signaling by interleukins IL10 STAT1 IL18 PTPN11 GRB2 TRAF6 TYK2 JAK3 SOS1 SHC1 STAT3 PMC5758399__F2 Top section: Mechanisms responsible for the cytoprotective and anti‐inflammatory effects of PARP inhibitors on non‐oncological diseases FOS GSK3B SSB CCL5 RNF146 CCL2 DDB2 PARG JUN PNKP APLF PMC5453942__F3 Map of DEGs in Oncopig leiomyosarcomas and their functions within the TP53 signaling pathway GADD45G SFN CD82 CDKN2A CCND2 CASP3 GADD45B CCNB3 RRM2B PERP CDKN1A SESN3 APAF1 PMAIP1 CCNB1 MDM2 CASP9 CCND1 THBS1 SESN1 ATR GTSE1 CYCS BAX PMC2410298__F1 TOLL-LIKE RECEPTORS REGULATION OF VIRAL INFECTION AND DISEASE TLR7 TLR4 TLR9 TLR1 TLR3 MAVS PMC5453942__F4 Map of DEGs in Oncopig STS cell lines and their functions within the TP53 signaling pathway GADD45G STEAP3 SFN PTEN MTOR CDKN2A CDK6 CASP3 CCNB3 IGF1 PERP CDKN1A CCNB2 PMAIP1 CCNB1 MDM2 CCND1 SESN1 GTSE1 PMC9623116__F1 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential MCU STIM1 STIM2 PMC4236713__F8 TBB through the non-mevalonate pathway and gene annotation in T CIT IPP MAL PMC11354688__F5 Process of human steroidogenesis HSD11B2 HSD11B1 CYP11A1 HSD3B2 HSD17B1 HSD17B2 CYP17A1 STAR PMC5352388__F7 N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways MMP7 MMP14 MMP2 MMP9 CCND1 CDH2 PMC7611845__F1 Driver pathways in the pathogenesis of marginal zone lymphoma NOTCH2 IRAK1 TRAF6 IRAK4 MYD88 MTOR BTK CARD11 BCL10 BCR BASH LYN SYK CD19 PMC2944186__F1 Convergence between Wnt and EGFR pathways EGFR LRP5 LRP6 TGFA NKD2 PMC8074257__F4 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers TSC2 TSC1 GC PTEN RPS6 PMC4918710__F1 Alternate complement pathway HEL-S-62p C9 CFB CFD THBD CFH C7 C6 CFI PMC4760064__F3 Gene regulation by peroxisome proliferators (PPARs): the most significant pathway from Crohn’s disease (CD) FOS LDLR IL6 SP1 JUN TF CYCS CCL3 PMC8074257__F1 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers SOCS3 PTEN SH2B1 MTOR FOXO1 STAT3 PMC2891948__F2 Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens CDK5 DRD1 DRD2 BDNF PMC7395869__F1 Means to inhibit canonical HH, WNT and NOTCH pathways SUFU PTCH1 PORCN SMO PMC7905009__F3 Scheme representing the different regenerative processes promoted by TGFB/activin signaling MMP12 SOX2 SMAD2 TGIF1 TBR1 TGFB1 PMC6605064__F1 Schematic diagram illustrating the UPR signal transduction pathway ATF4 EIF2A BCL2 TCHP XBP1 CP PMC6391951__F11 Illustration of most of the proposed modes of action of antitumoral POMs VEGFA NDP BAX PMC7810549__F9 Xiaoyaosan exerts its antidepressive effects in rats with chronic restraint-induced stress via regulating the activation of the immunoinflammatory response induced by the TLR4/NLRP3 inflammasome signaling pathway in the colon NLRP3 TLR4 TRAF6 PMC8546956__F7 Comparative phenotypic and transcriptomic analyses unravel conserved and distinct mechanisms underlying shade avoidance syndrome in Brassicaceae vegetables KL CS PC KDR PMC8128982__F4 Depicting the proposed pathogenesis of MIS-C with COVID-19 (the proposed pathogenesis is a constellation of various hypotheses referred accordingly) VEGFA CD244 IFNGR2 IRF3 TNF MUC15 ECE2 PDC MUC4 CLEC14A CCL20 CCL28 P2RX4 PMC3997957__F1 Cell cycle arrest by CDKN2A MDM2 CDK4 CDC2 CDKN2A PMC6445394__F1 RIG-I, MDA5, LGP2, PKR, and TLRs3/7/8 are activated during viral infection in the presence of non-self dsRNA TBK1 STAT1 ADAR TLR7 STAT2 IRF3 MYD88 FADD TLR3 MAVS USP18 PMC6651977__F1 The ER stress pathway ATF4 EIF2A WFS1 RYR2 XBP1 PMC9251145__F9 Salvianolic Acid B Attenuates Iopromide-Induced Renal Tubular Epithelial Cell Injury by Inhibiting the TLR4/NFKB/NLRP3 Signaling Pathway NLRP3 IL16 TLR4 RELA MYD88 REL BAX PMC8466696__F3 Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changes G6PC3 HEL-S-30 PGM2 ACSS1 PCK1 ADPGK PFKM ALDH3A1 PGAM1 HEL-S-133P HEL-S-68p HEL-S-162eP PMC9462548__F1 The JNK Pathway in Bladder Cancer BAD SRC MTOR DKFZp686F0183 BAX PMC5572386__F2 Apoptotic and necroptotic mechanisms TRADD CYLD BCL2 CAD TRAF2 FADD MLKL BAX PMC3098789__F6 Portion of the 'Toll-like Receptor Signaling' pathway for two representative cell lines TLR9 CASP8 FADD PMC2593566__F3 JAK/STAT signaling pathway and SARS-CoV STAT1 STAT2 IRF9 JAK1 PMC10452461__F2 Fusobacterium affects chemotherapy drugs TLR4 MYD88 PMC4986142__F1 Resistance to RAF inhibitors NF1 BRAF GRB2 PTEN PMC5959917__F6 Schematic diagram explaining the mechanism of CSC maintenance in cervical cancer via let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis HMGA2 EGF SOX2 EGFR MTOR PMC7424006__F10 TLR4 had an important proatherogenic role in monocytes/macrophages TLR4 VCAM1 TRAF6 MYD88 TIRAP PMC4997609__F6 Wedelolactone enhances osteoblastogenesis by regulating Wnt/Beta-catenin signaling pathway but suppresses osteoclastogenesis by NFKB/c-fos/NFATc1 pathway RUNX2 NFATC1 GSK3B PMC4724343__F3 Because KAT2B is a novel genetic susceptibility factor for drug abuse, we built a GeneMANIA () network centered around KAT2B to find related genes that may have functional links to drug abuse MAML1 KAT2B USF1 TCF3 TAF1B NOTCH3 CREBBP EP300 MAML2 MDM2 SNW1 BMS1 SMAD1 PMC8112447__F4 Zebrafish Cancer Predisposition Models NF1 GRB2 SOS1 HRAS MTOR TF CBL PMC8112447__F3 Zebrafish Cancer Predisposition Models TSC2 TSC1 APC GSK3B LRP5 LRP6 PTEN MTOR RHEB PMC7697917__F11 Enrichment of the neuroinflammatory pathway in microglia in cluster 1, based on the DEGs between cluster 1 and clusters 2–5 CS IRF7 IL34 IFNE CRP IL6 IL4 TNF PMC8226020__F5 Calcium Binding Protein S100A11 and Its Roles in Diseases SMAD2 SMAD4 HEL-S-43 PMC9149100__F7 Figure 3.Effect of CDK4 and CDK6 inhibition upon tumour cell-intrinsic and -extrinsic signalling pathways TSC2 RICTOR CDK2 CDK4 MTOR CDK6 RHEB PMC8112447__F7 Zebrafish Cancer Predisposition Models REV1 FANCD2 SLX4 TRAIP BRCA1 FAN1 ATM BRCA2 TOPBP1 FANCM RAD51 ERCC1 ATR RAD51C PMC7071697__F3 Complex mechanisms and signaling pathways underlying VM formation SMAD2 ZEB2 GSK3B PMC9149100__F1 CDK4 and CDK6 pathway in cancer CDKN2B CDK2 CCND1 CDK4 TOP2A CDK6 PMC3108692__F1 Mammalian target of rapamycin (mTOR) network TSC2 TSC1 PTEN MTOR RHEB MLST8 PMC9420941__F4 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases KEAP1 GPX1 NQO1 PMC9420941__F5 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases AMOT TAOK3 FGF19 AJUBA FGFR4 LATS1 INF2 RHO LATS2 TAOK1 TAOK2 PMC5391240__F5 MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2 SMAD2 APC GSK3B BCL2 FRAT1 PMC4662480__F6 Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma SRC TYK2 STAT3 PMC11743736__F1 Lipid metabolism pathways and promising targets for breast cancer treatment SQLE ACCS PC LPL LDLR CPT2 ACLY HMGCR PMC4055918__F1 Erythroid DAMPs drive inflammation in SCD TLR4 CD163 DNASE1 PMC5620554__F2 TRIMs in cytokine signaling TRADD STAT2 IRAK1 TRIM8 TRIM6 MYD88 STAT1 TRIM38 TYK2 TRIM28 JAK1 TRIM24 TRIM27 TRAF2 STAT3 TAB3 PMC6175656__F3 TRPCing around the Hypothalamus POMC SOCS3 PMC5000685__F2 Diagram of LPS-induced TLR4 signaling CD14 TLR4 IRAK2 LBP TRAF6 IRAK4 ECSIT MYD88 PMC3691765__F1 Apoptotic signaling pathways CAD FADD PMC3691765__F4 HTLV-1 and apoptotic signaling pathways BAD BAX PMC8351892__F1 Tracing the roots of CLPD-NK by TET2 and STAT3 STAT3 TET2 PMC3983582__F2 Nucleotide excision repair (NER): the proteins associated with human diseases are highlighted XPC ERCC1 PCNA PMC2645908__F5 Model showing RBR3 role in the RBR/E2F pathway controlling the expression of MCM2–7 genes, DNA replication, and cell transformation MCM3 MCM5 MCM6 MCM2 MCM7 PMC12110399__F3 LGR5 potentiates the WNT–Beta-catenin signaling pathway that maintains the stem-cell-like phenotype, impeding cellular differentiation ZNRF3 RNF43 LRP5 LRP6 GPR49 PMC9579211__F3 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways TSC2 PTEN MTOR RHEB PMC5753667__F2 The mammalian polyamine pathway SMOX SRM PAOX SMS PMC10521506__F10 Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis SOCS2 PHLDA1 BAX PMC9579211__F4 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways HEL25 PMC9579211__F6 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways ADAM10 ADAM17 PMC5150411__F1 Metabolic pathways expressed in the deep subsurface MTR HBD GCK CAD HEL107 RPE HPR HEL-S-162eP PMC9389535__F2 Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota IL18 CD80 TNF TSLP IFNG PMC9175089__F6 Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling EGF ARHA RAC1 CDC42 PMC4304082__F2 Piece #2: The BCL-2 family controls BAK/BAX activation and MOMP BAD BAX PMC4304082__F1 Piece #1: Tumor suppressor and oncogenic pathways converge on the mitochondrial pathway of apoptosis MYC MDM2 CASP9 PTEN PMC6407368__F2 Ca2+signaling pathways in Beta-cells SIK2 GSK3B CRTC2 DYRK1A PMC6398521__F4 Effect of 1,25(OH)2D3 and AB on the key reactions involved in the sphingolipid metabolic pathway GC CERS3 LASS1 CERS5 CERK CERS2 CERS6 PMC6662982__F8 In metabolic syndrome, hyperglycemia, and hyperlipidemia cause nutrient overinflux to kidney cells leading to increased celllular metabolism, which elevates intracelluar levels of citrate and ATP TNF HMGCR CD36 PMC10478980__F4 Process of apoptosis TRADD APAF1 BCL2 TNF FADD BAX PMC3444148__F1 Nodal signaling pathway in melanoma NOTCH4 NODAL SMAD4 GSC PMC3304012__F3 Landscape of EGFR Signaling Network in Human Cancers: Biology and Therapeutic Response in Relation to Receptor Subcellular Locations EGF EGFR COX11 PMC10478980__F1 Process of necroptosis NLRP3 RIPK1 TLR4 TRADD RIPK3 RIPK2 TNF TRAF2 FADD MLKL PMC8945338__F3 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway FOXO3A YAP1 NF2 MOB1A MOBKL1A OSM OPA1 MX1 PMC7655915__F7 Proposed model of the stimulatory effect of growth differentiation factor 8 (GDF8) on relative transwell cells in human trophoblast cells SMAD2 SMAD4 FSTL3 PMC5485291__F2 MTOR signaling pathway and the possibility of curcumin's pharmacological action on the pathway in the treatment of SCI TSC2 RICTOR PTEN EIF4E MTOR RHEB MLST8 PMC8945338__F2 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway SOX2 YAP1 PITX2 APP LATS1 LATS2 PMC5888808__F1 Programmed death-ligand 1 (PD-L1) is the ligand of programmed death 1 (PD-1) receptor YAP1 ALK EGFR CDK5 MTOR IFNG STAT1 SRC JAK1 PSMB9 IRF2BP2 PSMB8 IRF2 STAT3 PMC4809260__F2 Oxidative stress under ambient and physiological oxygen tension in tissue culture TLR4 KEAP1 ATF2 RELA BAX PMC4188627__F3 Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes ME1 MALL CDK2 CA14 COMP RAD21 DNA2 PCNA PMC3565254__F2 Pathways involved in endocrine resistance EGFR SRC HBEGF SP1 PMC11172744__F7 After TCR stimulation, two signaling pathways are induced via 3,4,5-triphosphate (IP3) and diacylglycerol (DAG) PLCG1 ZAP70 ADPGK GPD2 LAT PMC3335396__F1 Ligand-dependent activation of the Hh pathway PTCH1 SHH SMO PMC9350412__F7 SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy TBK1 TH CGAS IRF3 ACE2 PMC3385714__F3 Paralvinella conceptual glutathione pathway and responses to thermal exposure HEL-75 PALM PMC2180215__F1 Comparison of the protein kinase/phosphatase signaling pathways in flies, worms, and humans (see text for description) HEL70 LCK ZAP70 GRB2 SRC SYK PTEN MYD88 CDC42 PMC8316205__F5 Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis HOXA11 EGF PGRMC2 TOB1 HOXA10 FKBP4 PGRMC1 FOXA2 PMC8960399__F2 Proposed signaling pathways underlying the antidepressant-like actions of arketamine and TGFB1 TGFBR1 TGFBR2 BDNF PMC7758413__F5 Gene function network revealed a core role of the AP-1 linked signaling pathways during the recovery of COVID-19 PIK3R1 CXCR1 SET SOCS3 CXCL8 IL8RB CXCL2 TNF HIF1A CCR1 IFNG CXCR4 RORA JUN SOCS1 PMC8105091__F9 Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway GCLM TLR4 GCLC MYD88 PMC8026647__F4 Reconstructing directed transcriptional networks and master regulators in ccRCC MUC1 RIT1 ASF1B HSF4 PLEKHG3 IQGAP3 PAQR7 FOXM1 GIT2 ASF1A HMOX1 PLXNB1 PLEKHG4 AMFR PLD2 KNTC2 DIRAS2 KDM4B EZH2 CDH2 ALDH1A2 AXL CREB5 MAP3K1 KCTD1 ZNF232 SCARB1 ARHGAP24 ZNF44 ZNF608 MCM7 TSPAN6 ZNF320 UHRF1 ARRDC2 ZNF630 DERL1 MCM5 QRFPR MMP14 CLEC2D ABCG1 BNIP3 BARX2 EMX1 TRIP13 ABLIM3 PMC5366136__F5 Relationship between the nine DEGs in network 1 in the Jerseys LARS2 TRAPPC6B ETFB GIMAP8 GIMAP4 TRAPPC9 GNG10 DDT TMEM102 PMC5366136__F4 Relationship between 18 DEGs in network 1 in the Holsteins DGAT2 TBC1D8 SLC20A1 ELOVL6 FOSL2 TAF6 FGFR2 NR1H4 PMC5543131__F5 Differentially active pathways across pan-urologic genomic subtypes KEAP1 PPM2C SHMT1 PDP2 HIF1A HEL-S-32 MDH2 C9 C7 PDHA1 HEL-S-304 RPIA OGDH SDHD RPE HEL-S-133P HK2 SDHB HEL-S-281 ENO3 SDHC ENO1 DLD HEL-S-68p HEL-S-49 PDC LDHD PDK3 ENO2 HEL107 SLC25A1 HEL-S-62p PDK2 LATS1 PFKM LATS2 NF2 FH ACO2 CCND1 PFKP DLAT FASN ME1 HK3 WWC1 PGM2 PFKL PDK4 HEL-S-87p SDSL HEL-S-162eP PSAT1 PSPH C6 HEL-S-51e PMC4894314__F1 Effect of HDACI on cell survival signaling pathway in hemorrhagic shock GSK3B PTEN PMC6211728__F7 Phenethyl isothiocyanate activates leptin signaling and decreases food intake POMC NPY AgRP PMC4894314__F4 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock TLR4 IRF3 MYD88 PMC5597045__F2 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids SPI1 SPHK1 HEL-S-5 PMC5597045__F1 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids FAT2 FAT1 FAT3 FAT4 PMC6283154__F6 Summarization of DDT pathway selection in spn1 strains REV1 RMI1 PMC4923130__F1 Glucocorticoid-mediated modulation of pro-inflammatory pathways IL16 TLR4 GC MYD88 PMC3587991__F1 P53 signaling pathway interacts with chromatin-remodeling factors in response to DNA damage EP400 HDAC1 BRCA1 SIRT1 PMC5564318__F3 Up and down-regulated metabolic proteins in PANC-1 cells CS FH ENO2 PMC3587991__F2 Chromatin-remodeling factors affect the cell cycle SMC1A ATM SMC3 STAG3 CHD4 HK2 PMC8286839__F7 Feedback inhibition arising from NFKB activation operates at all levels in the pathway SIGIRR CITED2 PMC8286839__F6 Canonical and non-canonical NFKB signalling pathways CAP2 TLR4 CAP1 TRADD RELB BCL2L1 TRAF2 PMC8279535__F3 Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena TNF WNT10B FOXP3 PMC10376369__F7 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress GSK3B PTEN MCL1 BAX PMC3188682__F3 TGFB1/SMAD3 signaling as an integrator of fibrotic mechanisms in the kidney HGF USF2 KCP EGFR SRC BMP7 SKI PMC10376369__F5 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress BAD GSK3B BDNF ECE1 BAX PMC3727840__F2 TGFB in bone metastasis: novel therapeutic perspectives SMAD2 SMAD4 ARHA CDC42 PMC4922502__F2 Actionable drugs in proliferation pathway that have been evaluated in BRAFmut CRC BRAF APC GRB2 MTOR PMC8906035__F1 Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis IDO1 IL2 IDO2 IL6 IFNG PMC6530343__F2 Target sites of therapeutics along the pathogenetic pathway of celiac disease HLA-E CCR3 MICB GEM MICA TNF PMC6509151__F4 The role of FcμR in central deletion and B cell repertoire selection FCMR RAG1 JCHAIN FOXO1 PMC5718814__F2 Molecular mechanisms of DNA vaccines TBK1 TLR9 IRF7 IRF3 MYD88 AIM2 TLR3 PMC2754046__F1 Hypothetical schematic of a DAergic synapse TH DBH PMC6718713__F1 Microglial signaling pathways determining development of cells with divergent abilities CNTF NFKBIA IKBKE SOCS3 NPS CCL21 GDNF NOX4 IRAK4 PTEN JAK1 TNF PMC7782086__F8 Graphical abstract illustrates the function and regulatory mechanism of FOXD1‐AS1 in AGS PI3 PIK3CA EIF4E MTOR FOXD1 PMC8381052__F4 Autoantibody-Specific Signalling in Pemphigus PLCG1 DSG1 ARHA SHOC2 ERBIN PMC8968138__F1 NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance TSC2 BAD TSC1 NGF GRB2 PMC7056923__F3 Lactate is a signaling molecule in cancer and endothelial cells NDRG3 EGFR MTOR PMC8448164__F3 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action TSC2 BAD TSC1 IGF1R ERBB2 ERBB3 EGFR MTOR PMC8448164__F5 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action APC LRP5 LRP6 PMC8448164__F7 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action TSC2 TSC1 MTOR PMC7887252__F8 Proteins/enzymes in this pathway regulate both calcification and atherosclerosis ENPP1 APOE ENTPD1 PMC10572708__F12 Lipid and atherosclerosis metabolic pathway CD14 BAD TANK MCEE IRF3 TNF CASP3 NOG APOB LYN LBP CD40 SELP SELE TIRAP STAT3 TAB3 BAX PMC3962153__F2 Products for which C PDC NR1A2 HEL-S-162eP PMC7835977__F6 Proposed mechanism by which GAT107 restores bacterial clearance in the lungs by reducing oxidative stress, due to hyperoxia KEAP1 HEL-S-44 PMC8301062__F2 GSK-3B in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties GSK3B LAG3 ATR PMC3404195__F6 Proposed regulatory mechanism of ERB in colitis-associated colon cancer MUC1 STAT1 JAK1 MUC2 IL6R IFNG STAT3 PMC12124727__F3 Metabolomic analysis in QFA of WT, db/db and Mpst−/− mice PC PMC7438937__F5 Pathway enrichments of SHGS IGF2BP1 LSM6 LSM1 LSM3 A1CF ADAR LSM5 DCP2 LSM7 XRN1 LSM4 LSM2 SLBP PMC3313874__F2 Networks built using differentially expressed genes in uninfected macrophages from C57BL/6 and CBA mice CADM1 RSAD2 MT1E GDF15 CTSC PROX2 EMB AGTRAP IL10RB HLA-C PMC2689781__F7 Grade-dependent Proteomics Characterization of Kidney Cancer ALDOB FBP1 ENO1 ENO2 DLD HEL-S-87p SUCLG2 PCK2 PFKP ADH1C PMC9497807__F4 Polycomb Directed Cell Fate Decisions in Development and Cancer IL10 NUMB CXCL10 CCL2 CCL1 ID3 FOXP3 IFNG CXCL13 CCL24 CD163 CCL17 MICA IL2RA EZH2 GATA3 PMC10341937__F2 Canonical Wnt signal transduction pathway APC GSK3B LRP5 LRP6 PMC9497807__F2 Polycomb Directed Cell Fate Decisions in Development and Cancer CBX2 EPOP JARID2 EZH2 EZH1 SUZ12 AEBP2 PMC4926062__F4 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer EGF COX2 BAD MMP9 GRB2 CCND1 BCL2 HBEGF RALBP1 TGFA CYP2E1 PMC4926062__F2 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer EXO5 dik FAIM PNN PRIM2 KCNK3 NOL11 PRIM1 CRLF1 MCMBP SMCHD1 TRMT10C LIN7C EIF3M MCM10 GINS2 HMGB3 RIF1 RAB31 BARD1 AK4 KIFC2 MCM5 SAFB2 CLSPN PCF11 GJC1 CLIP2 PPM1D GINS4 CKAP2 KCTD9 WDR43 MIB2 SRRT EGFR HES4 SFRS3 ERCC6L DDX39A GINS1 PLD3 CHD3 OAS2 SLC67A1 TMX3 WDHD1 PPIC PSPC1 NCBP1 ARFGEF3 GINS3 MT1M POLD3 MTCL2 CCDC55 HEL-S-10 CMSS1 PIM3 NT5DC2 ALYREF PRMT3 TRA2B RBMX SRSF6 SRSF7 DCLRE1B PMC6614175__F4 Antioxidant mechanism of the NRF2 pathway KEAP1 NOS2 HMOX1 SRXN1 PMC2976847__F1 Cytokines, hormones or growth factors that activate Stat5 EGF BAD EPO TPO OSM STAT5B PMC4826150__F1 Regulation of target genes by the Wnt/Beta-catenin asymmetry pathway POP1 SYS1 PMC7437079__F3 STAT3 pathway and IL6/STAT3/S1PR1 amplification loop in IBD-CRC SOCS3 IL22 S1PR1 IL6 STAT3 PMC5739082__F1 Simplified schematic depicting the mTOR pathway and associated “mTORopathies.” The mTOR pathway involves 2 complexes, mTORC1 and mTORC2 TSC2 TSC1 EIF4E RHEB PMC7270529__F3 IPA’s individual pathway analysis of different proteins from the different experimental groups, linking them to a suggested promotion or inhibition of a cellular event under the umbrella of inhibition of cell death or change in cytoskeletal activity PTGER2 CS HSP90AB1 MYC ALOX5 GDI1 PHB2 PBR ANXA1 PTGS2 RTN4 PTGER4 ARHA ITGB1 PS1TP5BP1 TOMM70 TCP1 PRMT1 SPTBN2 STUB1 CHMP2B HEL113 GNAS BRDT RAN PXN ACSL3 PMC4697282__F1 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine LRP4 APC PORCN WLS PMC4697282__F2 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine PORCN TNKS WLS PMC5466605__F9 Illustration of a proposed signaling pathway of innate and adaptive immune activation in the Nx model (A) TLR9 IRAK1 TRAF6 CCL5 IL1R1 MYD88 NOD2 IFNG NLRP3 IL18 TLR7 TLR4 CASP8 JUN IL1B CD14 TLR5 IRF7 CXCL10 IRF3 TNF MAP3K7IP1 LBP CD40 CD80 PMC11980037__F5 Downregulation of Tnf, Il1a, and Il1b in M2c macrophages exhibited immune tolerance in autoimmune diseases IL21R TLR4 APC FOXP3 PMC2676994__F1 Schematic model illustrating multiple signaling pathways in regulating StAR gene transcription EGF SP1 PRL PMC5593680__F3 Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials TSC2 ATM EGFR EIF4E ACLY MTOR RHEB PMC4387772__F2 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation CD80 CTLA4 ARG1 ICOS CD36 HEL-S-162eP PMC4387772__F1 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation TSC2 TSC1 FOXO3A MYC PTEN CTLA4 HIF1A CIT SIRT1 FOXO1 FOXP3 PMC3193940__F2 An array of cellular stressors can perturb the folding environment in the endoplasmic reticulum (ER) leading to unfolded or misfolded protein ATF4 EIF2A BCL2 RCAN1 TRAF2 XBP1 PMC11980037__F3 KEGG disease pathways map analysis displays downregulated DEGs influenced by DEX-induced M2c macrophages involved in anti-allograft rejection APC CD40 CD80 TNF IFNG PMC8281885__F2 Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies SUFU SMAD2 LRP5 SMAD4 LRP6 SMO LATS1 MTOR LATS2 STAT3 PMC3717802__F6 Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer GIP GRB10 IRS1 RHEB PMC7657570__F1 Androgens facilitate SARS-COV2 entry through a TMPRSS2-mediated pathway ACE2 TMPRSS2 PMC6817822__F9 PR55A regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells LATS1 LATS2 PMC8012676__F9 Proposed model for effect of GNE mutation on actin dynamics and cell migration GNE SRC ARHA PMC5627884__F9 Kyoto Encyclopedia of Genes and Genomes and TGFB signaling pathway with changes between adult facial fibroblasts and neonate fibroblasts denoted by color code BAMBI FST NODAL SMAD2 SMAD4 SKP1 ARHA LTBP1 IFNG PMC6547527__F8 a The Spearman correlation coefficient revealed the association between the changes of fermentation parameters and the expression of these eight growth-related genes (SCC > 0.85 and p < 0.01) BAD ITGA6 TNFSF10 SNAI2 MAPK1 PMC7040073__F5 Changes in the transcript abundance of genes involved in central metabolic pathways, fatty acid biosynthesis, and the PKS-NRPS pathway HAAO KMO ENO1 HEL-S-5 PMC2945394__F1 Post-pandrial increase in insulin leads to induction of lipogenesis and inhibition of lipolysis LPL TG HEL-S-5 PMC6540047__F3A Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices TANK IFNA4 IRF9 ATF2 IFNE TRAF3 IRF3 IFNA5 IFNG ISG15 IFNA6 RIPK1 RERE AEN IFNA2 FADD GYPB MAVS PMC8699551__F5 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger ULK1 DKFZp686F0183 PMC8699551__F3 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger TBK1 ULK1 BAG3 BAG4 BAG6 OPTN NBR1 SIRT3 PINK1 MFN2 BCL2 BAG2 BAG5 PMC8924168__F5 BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling RPLP2 PML BAD RBM10 SRRT CDK12 SFRS18 MTOR SP100 BACH1 RPTOR BCL10 ARD1A CDYL TCF20 SCAF11 SSRP1 PRKAB2 FASN RPLP0 IWS1 THRAP3 PLEC HDAC7 MDC1 BARD1 PRPF40A CHD2 GYS1 RAD9A BRCA1 AEBP2 LIPE WAC MCM6 RPS17 ERBB2 RPS6KB2 TNS1 SRSF6 SRSF7 SHC1 PNKP UBAP2L NSUN2 ACIN1 PMC8236093__F1 Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS FPR2 LGR6 GPR37 PMC6712069__F1 An overview of Wnt signaling pathway ZNRF3 RNF43 APC SOST LRP5 RYK RHO AXIN2 JUN PMC4881503__F1 EPO-induced intracellular signaling pathways Erythropoietin and its receptor signaling through JAK2 activate multiple downstream signaling molecules including STAT5, PI3K/Akt, NFKB, and MAPK EPOR BAD EPO PMC6459341__F7 HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1B IL1R1 IL6 OSM IL1B STAT3 PMC3920756__F6 Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Oncogenes: Implications in Cancer and Pharmacogenomics APC MAL PMC5763539__F3 Pathway map for “LRRK2 and immune function in Parkinson’s disease” FCGR3A IQGAP1 STAR PSMD11 PMC7853124__F1 Immunopathobiology and therapeutic targets related to cytokines in liver diseases STAT1 CXCL1 STAT4 CXCL9 IL2RA IL12RB1 IL2RB PMC4587736__F1 Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex HEL70 STRIP1 CTTNBP2 STRIP2 MOB2 GCK LATS1 STK24 MOB4 PMC7953864__F6 Signaling pathway of MBHD-VD PPI network (blue and pink circles stand for compound target and VP genes, resp; red diamond stands for pathway; green hexagon stands for herb) LTA KDR NGF NPY SRC JUND SYK MTOR JUN TF CYCS CBL PMC8211386__F2 Cancer therapeutic approaches targeting apoptosis pathways BAD ATF4 MDM2 MCL1 DRD2 FADD CLPP BAX PMC8211386__F1 Apoptosis signaling pathways and pro-survival, immune, or tumor microenvironment influences that impact on them MYC PTEN CTLA4 MTOR RIPK1 ATM APAF1 ATF4 BCL2 MCL1 ATR FADD BAX PMC5763539__F4 Pathway map for “Inhibitory PD-1 signaling in T cells” CDK2 VAV1 SYK PTEN POR MTOR SKP2 PMC9220155__F3 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation BACE1 NLRP3 PINK1 CGAS TLR4 TLR9 KEAP1 TFAM CEBPB PMC9448813__F2 Notch signaling pathway ADAM10 ADAM17 HES1 PMC9957752__F13 Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease HHIP PTCH1 SMO IRS1 FOXO1 PMC9220155__F4 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation BACE1 NLRP3 CGAS TLR9 KEAP1 TFAM NQO1 CP STAT3 PMC6893479__F2 A summary of the main enzymes involved in the classic and alternative bile acid biosynthesis pathways CYP27A1 CYP8B1 CYP7B1 CYP7A1 PMC5411790__F1 Postulated interaction between enzastaurin and erlotinib in the EGFR pathway BAD GRB2 CCND1 PTEN MTOR PMC5004872__F7 Schematic showing proposed mechanism of ECM synthesis following CDH11 engagement CDH11 SMAD2 MYOCD RHO PMC6195642__F1 AKT/mTOR Signalling Pathway FOXO3A GSK3B PTEN EIF4E MTOR CD79B IRS1 FOXO1 CD79A RHEB TSC2 BTK TSC1 BCR BASH F3 LYN SYK PMC8624812__F3 Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19 NLRP3 ACE2 IL1B TMPRSS2 GSDMD PMC3089878__F2 Cholesterol transport in the CNS VLDLR PC LDLR PMC5626616__F1 TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines CD27 APC BCL2 FOXP3 PMC3262099__F8 The host cell EGF signaling pathway and proteins downstream of the EGF receptor that are activated in response to C EGFR SRC RAC1 PMC8252888__F9 GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway MTOR CDC42 BAX PMC7057844__F2 Molecular Mechanism of Runx2-Dependent Bone Development PTH1R RUNX2 PTCH1 FGFR3 SP7 PTHLH FGFR2 PMC9436900__F4 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities BAD TLR4 PTEN BAX PMC9436900__F2 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities ULK1 RIPK1 TRADD RIPK3 ULK2 FADD MLKL BAX PMC12056481__F4 DUBs in Wnt/Beta-catenin pathway, MYC signaling pathway and Hippo pathway in HNSCC APC LRP5 LRP6 LATS1 EZH2 USP22 PMC5384738__F4 Top networks and gene connections.Notes: Literature-based clustering of differentially expressed genes using Ingenuity Pathway Analysis (IPA) after 78 hours of 100 µM corilagin stimulation in SKOV3 cells HEL-S-1 EGFR LYN APP PMC10474083__F1 Detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification EN2 EN1 PMC12056481__F3 DUBs in the PI3K, TGFB and HIF-1A signaling pathway in HNSCC CYLD VHL SMAD4 PTEN HEL-117 MTOR OTUD3 USP1 PMC12056481__F2 DUBs in the p53 pathway, NFKB signaling pathway and RAS/RAF/MEK/ERK pathway in HNSCC USP4 CYLD EGFR MDM2 USP28 PMC11828970__F2 Simplified pathways of ammonia metabolism and treatment OTC ORC1L NAGS ASL PMC5864929__F4 Arachidonic Acid Metabolism Pathway ALOX15B LTA ADA PTGES ALOX5 PTGS1 MAL PMC7355739__F2 Modeling of the multiple functions of Reelin during migration, dendritic growth and synaptic development and the corresponding signaling pathways: (A,A’) GRIP1 SNAP25 MTOR CRK FBXO45 VLDLR SOCS7 ITSN1 DAB1 VAMP7 NECTIN3 CP NECTIN1 CDC42 PMC10516898__F15 Mechanism of D-TT-BMSCs inhibiting ferroptosis to repair the wound GPX4 FTH1 SLC7A11 SLC40A1 HMOX1 BACH1 PMC7986854__F7 MHC I antigen presentation pathway is down-regulated by multiple mechanisms in cancers RET STAT2 ALK SPPL3 MEX3C SND1 PMC5031610__F2 Current knowledge on the cell type/context-dependent regulation of Wnt/Beta-catenin signaling by NFKB pathway LEF1 APC PMC5306062__F2 Cell death induced by benzopyran compounds by minor chemical modifications of the benzopyran scaffold MTOR PMC5031610__F1 Current knowledge on the cell type/context-dependent regulation of NFKB signaling by Wnt/Beta-catenin pathway TLR4 BTRC APC TNFRSF19 PMC4630557__F2 Signaling pathways of main checkpoints molecules APC ZAP70 MTOR PMC4401268__F1A Dual role of Cav-1 Y14 phosphorylation: phosphorylat-ed caveolin (pYCav-1) is involved in the control of integrin-mediated signal transduction and caveolae-mediated cholesterol-enriched membrane microdomains (CEMM) endocy-tosis CSK SRC RHO PMC4801467__F1 Mechanisms and immunotherapeutic targets for glioblastoma (GBM) IL10 TBK1 IDO1 AHR IRF7 IRF3 FOXP3 PMC8199574__F3 Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know TH DBH PMC4322971__F3 Role of p53 in the progression of gastric cancer GC MDM2 PMC8301030__F10 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans TH CTSK RUNX2 BMP2 NFATC1 GC PMC6657254__F1 Summary of the neuroprotective action of resveratrol COX1 GSK3B SIRT1 BAX PMC7990077__F5 Proposed mechanistic diagram of the multi-faceted, anti-neoplastic effects of GSE against lung cancer PTGIS IGF2 PTEN IGF2R PMC5864729__F6 Schematic summary of mechanisms underlying VRCZ-induced skin cancer AHR CYP1A1 PMC12202337__F3 The ERK signaling pathway in regulating remyelination CNTF NGF GDNF BDNF PMC8946840__F2 Mesothelin: An Immunotherapeutic Target beyond Solid Tumors BAD FOXO3A CDK2 MSLN DKK1 STAT3 BAX PMC6042636__F2 Sox2: regulation of expression and contribution to brain tumors SOX2 SUFU SMAD2 APC SHH SMAD4 SMO TBR1 PTEN PMC5702855__F2 Multiple signaling pathways drive EMT in GBC cells APC GSK3B CD44 SHH SMO MTOR WIF1 CD24 PMC2211634__F3 Models for the dual roles of KLF4 and KLF5 in tumor suppression and oncogenesis KLF5 KLF4 BAX PMC9220225__F2 2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies VHL DEPTOR KDM4A PMC6407321__F4 Protection for oral SUB+IV vaccine against tick infestations in cattle TH HEL-S-62p IL16 IL1B PMC11387120__F3 Drug resistance mechanism of tumor immune microenvironment factors CCL8 JAK1 HIF1A CCL22 STAT3 PMC7779537__F8 Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS SMAD2 SMAD4 PMC4185425__F3 The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity APC CD80 CTLA4 PMC2613471__F1 Revisiting Notch in remyelination of multiple sclerosis lesions F3 NOTCH1 PMC10604135__F6 Mutated proteins in four patients colored with red, green, cyan, and brown with arrangements of their roles on Wnt and mTOR signaling pathways TSC2 TSC1 INTS6L SUMF1 FLNA USP9X EIF4E RPS6 WIF1 PS1TP5BP1 RPS6KA6 PMC8698499__F12 Novel Insights into the Prognosis and Immunological Value of the SLC35A (Solute Carrier 35A) Family Genes in Human Breast Cancer CDC20 RASSF1 PLK1 ATM CDC6 MADD APC ATR XBP1 SKP2 PMC4185425__F1 Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity PC APC ZAP70 CD80 CTLA4 PMC4158833__F4 Shaping the mammalian auditory sensory organ by the planar cell polarity pathway PTK7 DVL1 PMC5187940__F3 Effect of Pb on the signaling pathway TLR4-MyD88-NFKB and the production of pro-inflammatory cytokines in microglial cells ATF2 TRAF6 IRAK4 MYD88 JUN PMC5136547__F1 Innate immune response against rotavirus in intestinal epithelial cells (IECs) STAT2 FOS CXCL10 TRAF3 TRAF6 IRF3 TLR3 RNASEL STAT1 RNASE1 TYK2 JAK1 JUN MAVS PMC6891791__F4 Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol SI TNF MTOR PAH PMC3677900__F5 Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells EGF HGF EGFR STAT3 PMC6891791__F6 Immune system pathways in KEGG pathway analysis TH CASP3 PSCA TNF tal-1 FADD PMC6891791__F5 Nervous system pathways in KEGG pathway analysis NFKBIA MAPKAPK2 FOS ATF2 RELA APP ACHE NTRK2 JUN IRS1 BAX PMC9465410__F4 Exploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer’s disease BACE1 PSEN1 APP APOE PMC7395405__F4 Schematic diagram of signaling pathways in exosome-mediated autophagy inside target cell TSC2 TSC1 EGFR PTEN MTOR RHEB STAT3 PMC9019277__F1 Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer PITX2 PTCH1 SMAD4 SMO HIF1A ABCB1 PMC7084677__F1 Canonical phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin pathway PINK1 AMBRA1 PARL PMC5837509__F2 Apoptosis and p53 signaling related to Cr(VI) exposure BAD HP ATM ROCK1 BCL2 MCL1 CAD DIABLO HTRA2 CYCS GAS2 BAX PMC3919568__F7 Integrated metabolic pathway of BCAA metabolism MCCC2 OXCT1 MCEE BCAT2 HADHB HMGCL DLD ACADSB OXCT2 PCCA DBT PCCB SLC7A5 ACAT1 ABAT MCCC1 MLYCD ECHS1 ACADM PMC3095763__F1 Toll-like receptor Signaling in Neural Plasticity and Disease STAT1 CD14 EGR1 TLR4 STAT2 MMP9 IRF3 MYD88 PMC9526834__F1 Dietary Patterns and Gut Microbiota: The Crucial Actors in Inflammatory Bowel Disease MTOR MLKL PMC4783780__F8 Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite GNB2 PKIG HEL-S-1 HEL-S-99n GNG7 NACA RYR2 FXYD2 RGS14 HEL-S-11 KCNJ5 RGS6 ADRB1 ADRB2 RGS2 CACNB3 ADCY3 GNG3 KCNJ3 GNG8 CALM1 PLN YWHAQ GJB3 PKIB GJA4 ATP2A2 ADRA1A CASQ2 GJB6 ADRB3 GNB1 CACNB1 ADCY9 GNB4 ITPR2 PLCB3 GNG13 HEL2 SFN RGS18 GNGT1 RGS17 FKBP1A DKFZp686L0365 GNG4 CACNA1S GNB3 GNG2 PKIA RGS1 GNG11 GJB2 GJB1 YWHAG RGS16 RGS10 RGS11 GNG5 CAMK2D RGS4 CAMK2G RGS20 AMN PRKD1 KCNB1 GNG12 CHRM3 GJA10 GJA1 GJB4 GJB5 RYR3 HEL-S-93 PMC10252624__F1 Mechanisms of VEGF (receptor) inhibitors-induced cardiovascular complications VEGFC VEGFA VEGFB PMC11854354__F2 Signaling cascades generalized for ubiquitin-mediated IKK activation in IL-1R/TLR and TNF pathways TRADD IRAK1 SHARPIN TRAF6 IRAK4 MYD88 TNF OPTN TRAF2 TAB3 PMC3210079__F8 Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells NOTCH2 TWIST1 SMAD1 EPHA4 HES1 PMC10239259__F2 Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy KLF15 SAMD3 WWP1 MTOR IRS1 PMC10252624__F2 Primary mechanisms of ICIs-associated cardiotoxicity APC CTLA4 PMC11854354__F3 Ubiquitin-mediated IKK activation and Bcl10 autophagy in the T cell signaling pathway BCL10 LCK ZAP70 PMC3830939__F2 Tudor: a versatile family of histone methylation ‘readers’ ATM SGF29 POLL EZH2 UHRF1 PHF19 SUZ12 EED POLI PMC9843448__F1 Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies COX2 FGFR1 NUPR1 PDGFA CXCR4 FGF2 VEGFA CXCL12 SMAD1 DKFZp781O1323 SOX4 STAT3 PMC11500076__F2 STING signaling in dendritic cells (DCs) CGAS IRF3 PMC6770861__F6 A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability PLK1 MMP9 CCNB1 BAX PMC11481725__F2 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure FGF21 EGR1 MMP2 SMAD2 MMP9 PMC11481725__F1 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure FGF21 SMAD1 DKFZp781O1323 PMC11500076__F1 STING signaling pathway TBK1 CGAS IRF3 PMC5361499__F1 Amyloid precursor protein (APP) processing.APP preferred processing is the non-amyloidogenic pathway which digests with Alpha-secretase followed Gamma-secretase and takes place at the plasma membrane (PM) SORL1 BIN1 PICALM CLU PMC6175949__F8 Proposed positive feedback mechanism for Th17 cell-secreted IL-17A and NLRP3 inflammasome activity in a circuit NLRP3 IL16 NLRP1 IL1B PMC7452966__F1 Amino acid metabolism in pluripotency regulation PSAT1 ATF4 EIF2A GLDC PMC6560007__F1 MicroRNA biogenesis DGCR8 DROSHA CCR4 PMC6962107__F2 L-ornithine biosynthesis metabolic pathways in C PTS HEL107 PMC3694398__F5 NFAT Gene Family in Inflammation and Cancer COX2 NFATC1 IL11 IL4 PMC4246949__F9 Scheme of the regulatory interactions connecting PREP1 and PBX1 expression with the TGFB–SMAD3 pathway, cellular invasion, and EMT PBX1 JUN PMC6914882__F10 Schematic representation influence of PCr against DCM on Bcl-2 family members and other mitochondrial apoptotic and metabolic proteins in cardiomyocytes under various pathological conditions CASP3 CASP9 BCL2 STAT3 PMC5053108__F7 Role of miR-9 in zebrafish brain development.Notes: (A) Zebrafish forebrain: In the forebrain, miR-9 inhibits proneural gene her6 and targets Fgf signaling pathway genes (dusp6, pea3) FGFR1 ELAVL3 FGF8 ZIC5 PMC8185021__F6 Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation TSC2 MMP14 TSC1 CS SDC1 MMP2 MMP9 RHEB PMC4598091__F1 Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype HOPX DAP SYK PTEN PMC2743241__F1 Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents REN SUFU GLI3 GSK3B SMO DYRK2 PMC5751802__F3 Signaling pathways corresponding to Tables  and CDC20 ATM MDM2 PMC8639975__F4 Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training TNC CAMK2G ACHE PMC8990433__F1 Cholesterol metabolism and its implication in glioblastoma therapy YTHDF2 CYP46A1 EGFR LDLR SRC ABCA1 HMGCR PMC4058364__F7 HRG-mediated signaling via mTORC2 to mTORC1 TSC2 ERBB4 HRG ERBB2 ERBB3 RHEB PMC7859793__F5 Protein-protein interaction (PPI) analysis of differentially expressed alternative splicing (DEAS) events PIK3R1 COX14 NUMB TANK KIF23 PPFIBP1 RUNX2 F8 TROAP ARHGAP19 SLMAP INSR RARA PTPRS RPL21 SPTBN1 APP LEPR PICALM EZH2 ACAN NR1H3 ARHGAP22 RPL3 SVIL NCOR2 ARHGEF4 Meflin MAPK7 VCAN CD44 CHEK1 CENPK SMARCC2 ARHGEF11 CLSPN SSBP3 DKFZp686D2168 SYNC PIDD1 NEK2 TMEM237 CTNND1 EXOC1 GNAS MYLK CAMKK2 PMC8660802__F2 Biogenesis and release of exosomes TSG101 CD9 HLA-G CD63 CD81 PMC4199550__F3 Iron Necessity: The Secret of Wolbachia's Success? UROD UROS CPO PMC5727308__F1 WNT signalling pathways DAAM1 APC GSK3B ARHA ROR2 RAC1 ROR1 PMC7579760__F3 Hepatitis C virus life cycle CLDN1 EGFR LDLR RHO CD81 PMC8670090__F1 Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma ULK1 ATG12 ATG3 BCL2 ATG101 ATG10 ATG14 DKFZp686F0183 PMC9019160__F1 Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer, therapeutic treatment options for platinum-resistant ovarian cancer TSC2 BAD TSC1 ATM PDK2 GSK3B MDM2 CASP9 PTEN ATR RHEB PMC5138061__F1 Schematic representation of hypothesized cholesterol/phospholipid recycling mechanisms in the injured CNS VLDLR LDLR ABCA1 APOE PMC8712284__F4 Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production ARC GAL PMC5662062__F4 Replication Stress Response in Mammals and Trypanosomatids RAD1 TOPBP1 HUS1 ATRIP ATR PMC6325765__F6 Central carbon and Gamma-PGA production pathways PIG59 CS CIT RPE MAL PMC8395475__F2 Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance MMP12 IL13 IL6 IFNG PMC12109257__F6 MicroRNAs in oral cancer progression AGO2 DGCR8 EGFR MYC DROSHA RAN PMC6013441__F4 STRING pathway analysis of up- and downregulated genes in MDA-MB-231 cells co-cultured with adipocytes MGP EGR1 CFB RASD1 PTGS2 LTB IL24 STC1 CXCL2 IL6 ID3 CST1 KYNU GDF15 TNFSF10 CLDN7 HEL136 PSG6 CSF2 PMC10489936__F4 Polysaccharides modulate liver bile acids (BAs)-related signaling pathways of metabolic associated fatty liver disease (MAFLD) FGF19 FGFR4 PMC7255470__F7 Schematic representation shows the potential mechanism of Sevo-mediated anti-proliferation and anti-invasion roles in hepatocellular carcinoma cells GSK3B PTEN PMC7487481__F5 Metabolites, major metabolic pathways and pathway-related enzyme changes in palm oil-grown AMD1 CIT PMC7612806__F1 Simplified schematic of the KYN pathway IDO1 KYNU KMO PMC8358664__F2 P53 Family: A Role in Lipid and Iron Metabolism MLYCD ACLY FASN PMC7745315__F6 Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease NLRP3 IL16 PMC12084451__F7 The differentiation paths of gastric epithelial cells and signaling regulation EGF CHGB ZBTB7B MUC5AC ATP4B MUC6 NR3B3 XBP1 PMC4786305__F2 The Herpes Simplex Virus Neurovirulence Factor G34.5: Revealing Virus–Host Interactions STAT1 STAT2 IRF9 EIF2A JAK1 PMC5500819__F1 Schematic depiction of the strategy employed for mining the O-Man glycoproteome in cell lines with knock-out of COSMC, POMGNT1, POMT1, and POMT2 POMGNT2 POMT1 MGAT5 POMT2 PMC9281180__F2 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases IRAK1 GSDMA TRAF6 IRAK4 TNF GSDMD NLRP3 RIPK1 TLR4 GZMA GSDMC GSDMB TAB3 BAX DFNA5 PMC9281180__F4 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases HEL-S-62p NLRP3 DICER1 IRAK1 NOX4 IRAK4 MYD88 RPE CD36 PMC8804176__F2 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women TLR4 PGRMC1 BDNF GPER PMC9281180__F3 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases NLRP3 METTL3 HEL-S-44 TXNIP PTEN RPE GSDMD PMC8777261__F4 Proteomic analysis of metabolic pathways supports chloroplast–mitochondria cross‐talk in a Cu‐limited diatom PC TNLG7C HEL-S-162eP PMC11202538__F1 Canonical Shh signalling pathway KIF7 SOX2 SUFU PTCH1 SHH SMO PMC6409697__F9 rLj-112 was internalized with EGFR to suppress the downstream signaling pathways to initiate the anti-tumor steps in B16 cells EGF EGFR MTOR PMC4105535__F4 Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients LEF1 MYC DKK1 RB1 SP1 JUN BRCA1 BMP4 PMC4689162__F1 Beclin-1 interaction complexes Atg14L and UVRAG/Bif-1 activate the Beclin-1 complexes and induce the formation of autophagosomes in a mutually exclusive manner HMGB1 AMBRA1 TRAF6 UVRAG MAP3K7IP1 VMP1 PMC11202538__F3 Targeting the Shh signalling pathway regulators SOX2 SUFU PTCH1 SHH SMO PMC11202538__F2 Crosstalk with the Shh signalling pathway TSC2 TSC1 SOX2 SUFU APC PTCH1 SHH SMO PTEN RHEB PMC8245914__F10 HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/Beta-catenin signaling activation APC GSK3B LRP5 LRP6 PMC10372646__F1 Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms EGF IGF1 GSK3B SHH PTEN PMC9221433__F7 Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling ULK1 AKT1S1 RHO RAC1 EIF4E HIF1A MTOR EIF4EBP1 DDIT4 PDPK1 MAPKAP1 RPTOR RHEB INSR FKBP1A MLST8 TSC2 PRKCA RICTOR TSC1 PC DGKZ STK11 EIF4B PMC4689162__F3 Autophagy and some of its regulatory pathways Binding of insulin or growth factors to the insulin receptor triggers the PI3K pathway, converting PIP2 into PIP3 that recruits PDK1 and Akt to the plasma membrane TSC2 TSC1 ATG12 DKFZp686F0183 IRS1 RHEB PMC5136547__F4 Beneficial effects of immunobiotic bifidobacteria on the innate immune response against rotavirus in intestinal epithelial cells (IECs) STAT2 FOS CXCL10 TRAF3 TRAF6 IRF3 TLR3 RNASEL STAT1 RNASE1 TYK2 JAK1 JUN MAVS PMC6110855__F1 Phenotype change of microglia in neurodegenerative disorders SRA1 CD163 ARG1 IL1B PMC6892558__F4 East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide F11 GAL TRIO PMC4600211__F2 Pathway Express analysis of the host response to IBV infection in the trachea of susceptible birds (Line 15I) CD14 CTSS CTSK TLR9 HEL-S-99n TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 CD74 CPO IFNG CANX TLR4 TAP2 LBP CD40 CD80 B2M FADD TIRAP PMC5425374__F2 Hsp70 in signal transduction pathways SMAD2 SMAD4 TRAF6 PMC4946416__F1 PI3K/PKB/mTOR signaling pathway regulates cancer cell metabolism TSC2 TSC1 MYC MDM2 MTOR RHEB TCF4 FASN PMC8699194__F1 Insight into the Double-Edged Role of Ferroptosis in Disease HEL-S-89n GPX4 KEAP1 SLC7A11 DPP4 CISD1 SLC3A2 PMC2939392__F2 Proposed inhibitory mechanisms of SOCS1 on TLR signaling TLR4 IRF3 MYD88 SOCS1 TIRAP MAL PMC8268847__F3 MRNA Translation by Hormone Receptors in Breast and Prostate Cancer EEF2K ELF3 EIF2A ELP3 CTU2 CTU1 ALKBH8 PMC5429724__F4 Intracellular levels of interleukins are related to circulating UCB and underlying molecular measures of heme catabolism CRP PMC5429724__F3 Graphical summary of inter-variable connections for the entire BiliHealth study population CRP IL1B PMC9531511__F2 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis ULK1 DKFZp686F0183 PMC9531511__F1 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis TBK1 CGAS IRF3 PMC9531511__F4 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis TBK1 CGAS GPX4 IRF3 POLI PMC9531511__F3 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis CGAS RIPK1 RIPK3 TNF IFNAR1 MLKL PMC11562918__F3 HSV-1 mediates innate immune signalling and escape strategies TBK1 CGAS NLRC4 TLR9 TRAF3 DDX41 TRAF6 IRF3 MYD88 TLR3 CBL NLRP3 MAVS IFI16 PMC11756206__F4 Signaling pathways regulated by H APC EGFR TNF PMC11756206__F3 Aberrant Wnt/Beta-catenin, STAT3, and Hippo/YAP signaling pathways activation in H EGFR SRC IL2 LATS1 RHO TNF STAT3 PMC9531511__F5 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis CGAS AIM2 IL1B GSDMD PMC10297881__F13 Apoptosis and p53 signaling pathway in all analyzed groups PIK3CD PIK3R1 TUBA4A CTSS NGF BIRC5 BCL2L11 CDKN2A CDK6 CCND2 GADD45B SIAH1 SESN3 RRM2 BIRC3 THBS1 CDC2 CTSL CTSO FOS MAPK10 GADD45A CTSH DDB2 TNF DDIT3 IKBKB BCL2A1 IGF1 CCNB2 TNFSF10 CTSC BCL2 SESN1 SESN2 TNFRSF10A GTSE1 PMC11756206__F2 Development of gastric cancer is induced by H TEAD4 TNF STAT3 PMC10297881__F12 Apoptosis and p53 signaling pathway in the control compared to adipocytes, chondrocytes, neural-like cells and osteoblasts PIK3CD PIK3R1 TUBA4A CTSS NGF BCL2L11 CCNG2 CDK6 SIAH1 TUBA1C RRM2 BIRC3 CCNB1 CCND1 THBS1 CDC2 CCNE2 CTSK FOS TNF PIK3R3 CHEK1 HEL-S-130P SPTA1 PS1TP5BP1 TUBA1A BCL2A1 IGF1 CCNB2 DAB2IP MAP3K14 TUBA1B SESN2 TNFRSF10A GTSE1 PMC9550864__F2 Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression HYAL2 CD44 PMC4537205__F5 Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway EIF4A1 EIF3A PRKAA1 PTEN HIF1A EIF4EBP1 MTOR PDPK1 MAPK1 RPS6 EIF4B VEGFA CAB39 IRS1 DDIT4 EIF4G1 RHEB TSC2 TSC1 PRKCB IGF1 RPS6KA1 RPS6KB2 AAG1 PPP2CA STK11 RRAGA PMC4386371__F5 Model for the role of specific acyl-CoA oxidase homo- and heterodimers in the biosynthetic pathway of (omega-1)-ascarosides (A) and omega-ascarosides (B) HEL-S-62p C9 C6 ACOX3 ACOX1 PMC6504559__F7 Schema of possible mechanisms of action of MyD88−/− donor T cells during aGVHD IL33 MYD88 PMC2408969__F8 Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence UBC CDC20 APC SKP1 RBX1 MAL PMC9101511__F3 Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies TRIL ULK1 TRADD ULK2 FADD AGL GSDMD TAB3 PMC8944605__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence SIRT2 NAMPT BMI1 HIF1A GATA4 SIRT3 SIRT7 SIRT4 SIRT5 SIRT6 F3 EZH2 SIRT1 PMC6117394__F4 Biochemical mechanisms of oncometabolite accumulation HEL-S-26 KEAP1 FH ACO2 HEL-75 PMC6117394__F3 Mitochondria at the crossroad of metabolic and signaling networks CS SHMT1 MYC GLS2 ACSS2 MTOR MTHFD2 HEL-S-162eP FH CPT1C HEL-S-51e SIAH2 ACLY HEL-S-133P TFAM FASN PMC5522055__F3 Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9 PCSK9 APOB AMFR HNF4A INSIG1 LDLR SREBF2 INS HNF1A MTOR HMGCR INSR PMC8101191__F2 Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression SOX2 PRKCB CD44 RELB ADAM10 TCF4 STAT3 PMC9367163__F7 Combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway ATG3 MTOR NOTCH3 PMC5706385__F6 Schematic model for ZJW extracts in inhibiting 5-HTR1D and attenuating Wnt/Beta-catenin signaling pathway MMP7 LEF1 MMP2 GSK3B AXIN1 LRP5 CCND1 DVL2 DVL3 TCF4 PMC7349567__F1 Regulatory metabolic pathways of ferroptosis GPX4 STEAP3 FACL4 SLC7A11 SLC3A2 IPP TF HMGCR GLS PMC6194902__F1 Terpenoids biosynthesis pathway (A), and pathway engineering strategies (B,C) HEL-S-62p C6 IPP TF PMC4405118__F1 A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome SUFU GLI3 SHH SMO PMC6105016__F7 Investigating genetic-and-epigenetic networks, and the cellular mechanisms occurring in Epstein–Barr virus-infected human B lymphocytes via big data mining and genome-wide two-sided NGS data identification SRI RPS14 SCO2 CD46 FOS CHMP5 TRAF3 PSAP RNF4 RGS17 KANK2 GRN RNF41 DKFZp686F0183 RBPMS SLC25A6 RAC3 F2 RELA GRB2 HEL-S-283 JUN BAX PMC4595346__F3 Connecting Myokines and Metabolism IGF1 ALK SMAD2 GSK3B SMAD4 CCND1 GDF11 PMC11670023__F1 Triggering receptor expressed on myeloid cells signaling pathway HMGB1 IRAK1 MMP9 TRAF6 IRAK4 MYD88 MAP3K7IP1 NLRP3 CARD9 TREM1 PGLYRP1 ZAP70 GRB2 CD177 SYK PMC4497387__F1 Radiation-induced acetylated and deacetylated proteins RPL12 GNB2 NPM1 HEL2 RPS2 TNPO1 RPS9 RPSA RPS29 RPS12 PS1TP5BP1 PMC8348158__F8 Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice ZNF183 IGF1R IGF1 GHR RHEB GP6 PMC8799879__F1 Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle HEL-S-92n CD80 PMC7279373__F1 Interplay between reactive oxygen species (ROS) and the central carbon metabolism ME1 HEL-S-162eP PMC6678695__F7 Scheme of autophagic cell death induced by the combination of Oxaliplatin and DHA ATF4 EIF2A SESN2 PMC4805512__F1 TNFR1-driven pathway RIPK1 RIPK3 TNF MLKL PMC6336165__F2 Theory for polymicrogyria and brain arteriovenous malformations in HHT BMP10 DLL4 VEGFA PTEN PMC7395594__F2 Nrf2-ARE and Wnt/Beta-catenin/GSK-3B intertwined signaling cascades MAF KEAP1 APC PMC3096496__F6 Model depicting the generation and consequences of ROS-mediated base damage NEIL2 MBD4 NTHL1 UNG NEIL1 PMC7501057__F7 Intercellular fibrin networks prevent erythrocyte leakage PLG VCAM1 REST PMC3580432__F2 Possible key signaling components in the force-mediated stem cell differentiation SUN1 HEL-S-62p VASP RUNX2 ARHA LPA PMC7985188__F1 Data, methods (a) and results (b) for TBNC network identification (A) Workflow of the proposed computational approach SET BRCA1 PMC9210594__F2 Potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review HGF RUNX2 RELA PAX7 VEGFA CCND1 BMI1 PMC8732357__F2 DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies ATM FAP SSB PARP1 ATR FANCE PMC11566155__F7 Axon guidance pathway analysis SEMA7A NCK2 RYK SLIT2 NCK1 FYN SHH SMO RAD1 gdf7 SEMA3A HEL-S-28 FES BMP7 ARHA ROBO2 RHOD ROBO3 CXCR4 PTCH1 ROBO1 RND1 CXCL12 SLIT1 PER3 CDC42 PMC3245021__F3 Reformatted modeling of the BioCarta ‘apoptotic signaling in response to DNA damage’ pathway BAD ATM APAF1 BCL2 BCL2L1 CYCS BAX PMC5573916__F3 Simplified mTOR signaling network with interactions inferred from modeling approaches TSC2 EGF TSC1 EGFR IRS1 PMC2919228__F6 Systematic Analysis of Essential Genes Reveals New Regulators of G protein Signaling FAR1 RHO CDC42 PMC5531453__F5 A, Multifactorial etiology of adhesion formation PLG HIF1A TF PMC2981460__F1 TGFB canonical signal transduction pathway and transcriptional responses mediating TGFB growth inhibitory effects SMAD2 SMAD4 PMC7882924__F9 Graphical illustration of the function and mechanism of miR‐144‐3p in combination with hBMSCs CCND1 CDK4 PMC11504891__F2 CSF-1R axis mediates the crosstalk between tumor microenvironment cells IL34 FAP IL8RB IL6 ARG1 PMC9512540__F3 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer SPANXN3 CRISPLD1 RTN4RL1 ACTRT3 ZC3H12D CRCT1 C2CD4A CFHR4 KRTAP5-10 C8orf48 PCDH7 DEFB1 SERTAD4 AKR1C1 PFKFB4 ZBED2 RGS22 DMRT1 NAP1L2 GPR87 CCR1 ANKRD1 TP53INP1 MPZ TIMP3 DACT2 TCN1 ACTBL2 CXCL11 FGA MMP10 SPANXN5 IL1A RSAD2 ENPP4 CD300C CD82 CXCL10 NPPB SLAMF7 SPINK6 SDC2 TIMP4 F5 SLC16A2 MSMB IFIH1 KLHL4 SAA2 GLS HEL-S-62p AFP CD33 EBP GDA CARD6 GLIPR1 PPBP RASSF9 ITIH2 TSPAN12 SESN3 SH3BGRL2 KCNV1 GBP2 HEL-S-8a ARL14 GBP3 SAMD9 CFHR3 SLCO4C1 KRT6A BMP2 PHTF1 HYAL4 MPZL3 F13B CYGB PMAIP1 GBP4 KLHL30 INHBA LCE1B PMC4930117__F1 DNA end resection dictates the pathway choice for both DNA repair and checkpoint response DSBs can be repaired by NHEJ or by HR that requires 3′ ssDNA generated by end resection ATM ATRIP RAD51 ATR PMC6413682__F8 Negative regulation between FoxO3a and EPS8 in EGF/PI3K/Akt pathway EGFR MTOR STAT3 PMC5573916__F1 Major mTOR signaling network TSC2 EGF TSC1 EGFR GSK3B PTEN TNF IRS1 RHEB PMC9512540__F6 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer STAT1 RSAD2 CXCL10 JAK1 IFIH1 CXCL11 PMC4487197__F2 Ephrin receptor signaling pathway (genes hypomethylated in the schizophrenia patient of Twin Pair 1) ANGPT1 EGF KALRN GRB2 APP SRC ARHA SDC2 PXN TSN CDC42 STAT3 PMC9590378__F1 Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance PINK1 GDNF IL6 BDNF DIABLO PMC8463184__F3 Idebenone-Activating Autophagic Degradation of Alpha-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach PIK3CD MAPK9 CCNA2 MAPK8 ALK EGFR MAPK14 DRD2 MTOR PDPK1 F2 NPY5R MDM2 APP SMO CHRM2 GAL PRKDC ABCB1 FASN PDE3B MAPKAPK2 PSEN2 NTRK1 AVPR2 IKBKB FER CNR2 PSEN1 CDK2 CHRM1 PPP2CA PIK3CA SYK MAPK11 PSENEN HCRTR2 TF PMC4613549__F1 Proposed mechanisms of evodiamine signaling in white adipocytes EGFR MTOR IRS1 PMC2824633__F4 Cyclin D3-specific deregulated genes and their functional networks IFIT2 TFPI RAB27A GANAB WBP4 CCND3 DBF4 CRLF3 CDK6 ARMC8 PLAGL1 CDKN1A BCAT1 SETD7 ARL6IP5 RYR1 TIA1 BEX2 TRIOBP ZNF91 SLC39A6 SKP2 PMC8328776__F3 High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury HMGB1 CXCL1 HLX PTGES CCL7 MYD88 MMP3 COX2 TLR4 CLCF1 LYN CDC2 SELP GAL SHC1 STAR PMC5715373__F1 Strategies to generate tolDCs for clinical therapeutics CD40 CD80 PMC7299681__F7 Proposed model of WDR41‐mediated cellular processes in TNBC cells GSK3A WDR41 PMC275444__F7 Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility HEL-S-62p PAK1 ARHA RAC1 CDC42 PMC12106489__F7 Wnt7b promoting renal fibrosis in AAN APC PORCN WNT7B PMC5488057__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks COX1 IGF1 MPO VCAM1 PMC6781771__F5 AKR1C1-3 are involved in a pathway with 44 unique interactors CREG1 AKR1B10 OSGIN1 SLC7A11 SOST AKR1C1 TFRC ADH7 TXN ABCB6 GPX2 ABCC5 ABCC2 UGT1A7 ME1 UGT1A3 PTGR1 GCLM CES1 HEL-S-25 GCLC TP63 FTL HEL-S-53e UGDH ADH5 AKR1C2 MGST1 ABCC1 HEL-75 ALDH3A1 HEL107 SRXN1 PMC7937672__F1 Cutting the molecular brakes to achieve cardiac regeneration RAPGEF5 HEL-S-28 TEF LRP5 LRP6 HIF1A PMC9633658__F1 Muscle-specific MicroRNAs in patients with chronic obstructive pulmonary disease and skeletal muscle dysfunction IGF1 MTOR BDNF PMC3480380__F8 Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7 EGF BAD HEL-S-28 EGFR CDC37 PTEN TNF MTOR RHEB TSC2 TSC1 MDM2 GRB2 CCND1 TGFA PMC3932922__F1 Cartoon presentation of LRRK2 showing multidomain structure LRRK2 BAG5 PMC5115958__F2 Non-invasive metabolic imaging of brain tumors in the era of precision medicine MYC LAT PMC5115958__F1 Non-invasive metabolic imaging of brain tumors in the era of precision medicine TIGAR MYC PMC4741450__F9 Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway ATM CCNB1 ATR PMC6004600__F2 Innate immune receptors drive dengue virus immune activation and disease TBK1 SYK CCL4 CCL2 MYD88 TNF IL1B MAVS CCL3 PMC164216__F5 TLR signaling pathways LTA TLR4 TRAF6 MYD88 MAP3K7IP1 PMC8011326__F3 Shh pathway regulated by MID1 MID1 SHH BMP4 PMC8166678__F7 “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells FOXM1 EGFR CCND1 HBEGF CDK4 CDK6 PMC4281293__F2 To reveal potential pathways involved in pancreatic cancer survival, the Ingenuity Pathway Analysis (IPA) was used for upstream regulator analysis SET SLC25A5 HEL-S-25 VEGFA HEBP1 PPP2CA PCBP1 MFAP4 S100A6 CBFB MDH2 PMC9178660__F2 Advances in Immunosuppressive Agents Based on Signal Pathway COX2 TRADD TRAF5 IRAK1 TRAF3 RELB TRAF6 IRAK4 MYD88 TNF TRAF2 LTBR PMC9178660__F4 Advances in Immunosuppressive Agents Based on Signal Pathway KEAP1 PPL GSC PMC11461658__F3 Tryptophan-kynurenine metabolic pathway HAAO HEL-S-90n KYNU KMO PMC9178660__F3 Advances in Immunosuppressive Agents Based on Signal Pathway TSC2 EGF TSC1 IGF1R PDK2 EGFR PTEN INPP4B MTOR IRS1 RHEB PMC8607389__F5 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease BACE1 PC GSK3B ARHA RHO LPA PMC8607389__F2 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease DOK3 VAV3 GRB2 SYK PTEN SOS1 MTOR LAT APOE CDC42 VAV2 PMC4931191__F2 Relationships between longevity genes affected by the diabetic milieu MTOR SIRT1 PMC8607389__F1 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease ROCK2 BAD MDM2 CASP9 CCND1 BCL2 ARHA PTEN MTOR PMC6712508__F6 The proposed mechanism of TN-C release following RV infection of bronchial epithelial cells TLR7 LDLR TLR3 PMC8289367__F3 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer YTHDF1 VIT PMC8616136__F1 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy WNT3A APC GSK3B LRP5 LRP6 DKK1 WNT10B PMC2860348__F1 p38 MAPK mediates the transcriptional response to stress RUNX2 ID4 ATF2 MYC GATA6 NFKBIZ HOXC12 SOX9 FOXC1 FOXG1 IRF-1 JUN PAX1 LHX5 EGR1 SOX2 MAFF NFATC1 FOS ATF3 ID1 DDIT3 FOXD1 FOXA2 GIG8 EGR2 TGIF1 PMC8616136__F3 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy APC GSK3B LRP5 LRP6 DKK1 PMC8616136__F6 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy APC GSK3B LRP5 LRP6 DKK1 PMC5291375__F7 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets NPB BAD GFAP PTEN RAC1 MTOR RHEB PI3 TSC1 BCR HEL-S-11 MDM2 SYK RAF1 EIF4B RBL2 CD19 PMC8049318__F1 MiRNAs and coding genes involved in the milk fat synthesis pathway OXCT1 ACACA BDH1 ACSS2 HEL-S-5 HMFN0839 DGAT1 SCD LPIN1 ACSS1 LPL ACSL1 FASN CD36 PMC4915567__F1 Melatonin pathway and melatonin candidate genes ASMT ADRB1 MTNR1A AANAT MTNR1B PMC6437685__F2 HEV infection leads to the expression of IFN and other proinflammatory cytokines through activation of interferon regulatory factor 3 (IRF3) and nuclear factor kB (NFkB) pathways TBK1 STAT1 STAT2 IRF9 IRF3 PMC5291375__F3 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets FHIT BAD PTEN MAL PMC8482137__F5A Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups IL10 PIK3R1 IFNA1 CCR3 TGFBR1 TGFBR2 IL6 IFNAR1 TBX21 IFNA13 CD40 GFI1 JAK1 JUN TGFB1 STAT3 PMC12163381__F4 ILs with dual functions STAT1 IL33 JAK3 JAK1 STAT3 PMC10937442__F8 Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells IL13 IL4 IL5 PMC12163381__F3 ILs mitigating AKI progression STAT1 IL13RA2 STAT4 TYK2 JAK3 JAK1 IL17RB IL2RB STAT3 PMC12163381__F2 ILs exacerbating AKI progression STAT1 STAT4 TYK2 JAK1 STAT3 PMC3826519__F7 Deregulated genes upon miR-196a overexpression in keratinocytes NFATC4 E2F4 HOXA9 SMPD2 CDKN1B CCL2 RB1 HSPB3 TNF NCAM1 E2F3 CDK2 TP73 APP CD40LG SYNM RBL2 PMC2737093__F6 Schematic view of PPARG activation in VSMCs EGR1 MMP24 SMAD2 PMC10571713__F1 Lipid sources include the de novo fatty acid synthesis pathway and exogenous lipid uptake ACLY FASN PMC7508399__F5 Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies CS CD80 RXRA MEF2D PMC8316833__F3 SUMO and SUMOylation Pathway at the Forefront of Host Immune Response STAT1 IRF7 IRF8 KLF4 IRF3 JUNB TRIM5 IRF4 IRF2 IRF-1 STAT3 PMC3154612__F1 Simplified diagram illustrating the mTOR signaling pathway EIF4E MTOR EIF4B PMC6660835__F1 Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS TBK1 MRPL18 MAVS PMC10382489__F3 PTMs involve some mechanisms in CVDs MFN1 MFN2 PTMS TXNIP PMC8289367__F2 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer YTHDF1 METTL3 CCR7 CD40 CD80 HEL-S-133P TIRAP PMC2950652__F2 Pioneer Round of Translation: Features and Functions ELF2 PABPC1 ELF3 MAGOH EIF4B CTIF PMC4657151__F1 Skeletal muscle as an endocrine organ: PGC-1A, myokines and exercise MTOR SIRT1 SIRT3 PMC6961892__F7 Liganded T3 receptor B2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production TSHB TRH MSX1 SF1 CGA PITX1 GATA2 PMC3429058__F1 HDL promotes regression CCR7 CCL19 ABCA1 CD36 PMC11411607__F3 Canonical and non-canonical NFKB signaling pathways by andrographolide BCR RELA RELB TNF PMC4299486__F2 Endocrine system development and function MYRIP GPR55 ANGPTL4 GPRC5C BDKRB1 PROKR1 GPR119 BNC1 ANGPTL1 SUCNR1 CLEC4A TRPC5 KRT14 PMC4299486__F1 Cell signaling CCNK SST HEL2 SPSB4 FOS GPR171 RSF1 BRCC3 TNF GPR152 GPR174 ORMDL3 RNF20 GPR157 APP TGFB1 GPR162 PMC7918665__F2 Major groups of micro RNAs (miRNAs) and their related pathways by which they act on endothelial cells ALB GRB2 PTEN MTOR BAX PMC9178660__F6 Advances in Immunosuppressive Agents Based on Signal Pathway PAK1 TRADD JUND TRAF2 CDC42 PMC9178660__F5 Advances in Immunosuppressive Agents Based on Signal Pathway EGF GRB2 PMC2820658__F1 Induction of IFNs after virus infection in IFNB pretreated human DCs IRF7 TYK2 JAK1 PMC7850581__F1 Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family STAT1 GBP1 STAT2 IRF9 APC GBP2 RELA LRP5 GBP5 LRP6 TYK2 JAK1 PMC6321285__F1 HGF/c-MET signaling PAK1 HGF GRB2 SRC RAC1 MTOR STAT3 PMC7980187__F9 Possible signaling pathways utilized by SARS-CoV-2 for cellular hijacking ITK PI3 LCK GRB2 SRC IRF3 RHO RAC1 ACE2 PMC1083688__F2 Curbing the nuclear activities of Beta-catenin NLK TBP POP1 POLI PMC8318926__F1 Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy CXCL1 NONO ARHA PMC6349702__F2 Protein-Protein interaction network of the 214 identified proteins: network nodes represent proteins, network edges indicate the strength of data support (STRING v10.5) MGLL TPM3 NME2 STK24 PPBP MDH2 HEL-S-108 CLC SRC THBS1 CNN2 CAPZB RAB13 STOM PF4 EHD3 MAPRE2 ARHA RALB HEL-S-21 HPSE NAPA TAGLN HEL-S-69p HEL-S-22 DKFZp761E1322 LIMS1 DCD YWHAQ HBB PPIB SELP PLEK RAN POLM PNP PMC7198573__F3 Map of the T-cell receptor signalling KEGG pathway for Mus musculus, with the colour of nodes representing the level of individual variability in response to stimulation with anti-CD3 and anti-CD28 antibodies in Microtus agrestis IKBKG CHUK PPP3CA SOST GSK3B CST2 PDPK1 NCK1 FYN MAPK1 CD40LG CDK4 CD3G ICOS CD3E CD3D FOS MAP3K7 ARHA TNF HRAS IKBKB CARD11 PAK1 NFKB1 GRAP2 ZAP70 GRB2 MAP3K14 MAP3K8 RAF1 MAPK11 LAT PMC5695813__F5 Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells RFC1 CETN2 POLE RPA1 MSH6 PARP2 XPC ERCC5 UNG CDK7 MPG RFC3 PMC5457443__F6 Functional analysis of IRF5 pathway CDK17 CNGA1 DHX58 MMP24 MMP11 GPS1 MAP2K2 HUWE1 UBE2T FBXO34 PFKM RIPK2 MRGPRG ASB11 ENPP7 RNF26 GPR85 GRID2 KCNN2 GPR132 TACR3 RNF39 TMPRSS2 PMC8905437__F1 Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis CIRSR TNLG7C GLA PMC9426616__F2 Human immune polymorphisms associated with the risk of cryptococcal disease TBK1 TLR5 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 CARD9 TLR7 TLR4 BCL10 SYK RAF1 PMC3906588__F1 UPR response underling memory consolidation in Alzheimer's disease ATF4 EIF2A APP XBP1 PMC6879357__F6 Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm TH CD99 CD6 ICAM2 ESAM CLDN2 ITGA4 SPN SELL MPZ CD2 CDH2 PTPRM ICOS SELE CD34 APC NRCAM TIGIT PTPRC ITGAM SELPLG CNTN2 CDH4 ITGB7 ITGA6 CD22 CD40 CD80 ITGAV SELP CD226 JAM2 NTNG2 PMC4506163__F4 Gene product association networks extracted from the most significant (A) cellular and regulatory process pathways and (B) metabolic pathways involved in arteriotomy-induced carotid stenosis (listed in Table ) EAPP ENO1 ASPA PMC7316184__F1 Trimethylamine N-oxide (TMAO) metaorganismal pathway NLRP3 ABCG2 FOXO1 PMC12245910__F2 The TSCC in the mTORC1 signaling pathway TSC2 TSC1 TBC1D7 CDC2 MTOR DEPTOR RHEB MLST8 PMC3836826__F3 Stress-response pathways are altered in the hippocampus of chronic alcoholics TLR4 TXNIP IL6 IL1B PMC7883599__F4 SIRT1 and SIRT2 in Huntington’s disease SIRT2 UCP1 BDNF SIRT1 PMC9152417__F8 Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway NOTCH1 BTBD7 HES1 PMC7736111__F2 Molecular and signaling pathway implicated in host cell antiviral response TBK1 TRADD TRAF5 IRF7 TRAF3 TRAF6 IRF3 ACE2 TRIM25 TRAF2 MAVS PMC10476815__F6 Predicted targets of Ruxian Shuhou prescription in the PI3-Akt signaling pathway BAD CD37 MYC PTEN MTOR RHEB RXRA TSC2 BCR MDM2 GRB2 CASP9 SYK GAL RBL2 CD19 PMC4400874__F3 Initiation and perpetuation of NLRP3 inflammasome activation and assembly NLRP3 CASR GPRC6A TRPV2 TRPM2 PMC3285438__F5 Simplified signaling pathway of the effects of resveratrol involved in metabolic control in the skeletal muscle RBP4 IRS1 SIRT1 PMC6089393__F9 PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations NR3A2 PDE3A AKAP6 VEGFA CREB1 HIF1A NMT1 GATA4 CACNA1C GATA2 ZDHHC21 EDNRB KLF2 NOSIP BDKRB2 ETS2 SP1 NMT2 MEF2C SP3 MYOG PMC10458348__F4 Histone Modification of Colorectal Cancer by Natural Products APC GSK3B MYC CD44 LRP6 PMC3269610__F2 BMP signaling and negative regulation in bone formation RUNX2 SOST MSC DKK1 PMC5743847__F1 Lipoquality control by phospholipase A2 enzymes LTA COX1 LTB PMC3309723__F5 Parp1 mediation of Sox2 activity in ESC pluripotency SOX2 LIF PARP1 PARG STAT3 PMC11531143__F4 PIM1-mediated signaling pathways in lung cancer PIM1 GRB2 MTOR HEL-S-133P HK2 TAB3 BAX PMC11531143__F3 PIM1 signaling in Hepatocellular carcinoma PIM1 BAD EGFR IL6R PMC11531143__F5 PIM1 activates AKT signaling in ovarian cancer EGF PIM1 BAD EGFR CCND1 GDNF VILL MTOR CDK6 HEL-S-68p PMC9659297__F4 Biological Relevance of Papaverine in Cancer Cells EGF RICTOR RHO PTEN MTOR PMC8157467__F7 3-Methyladenine but not antioxidants to overcome BACH2-mediated bortezomib resistance in mantle cell lymphoma BACH2 HMOX1 BACH1 PMC6053318__F2 Everolimus and Sirolimus in Transplantation-Related but Different TSC2 BAD TSC1 MDM2 EVL PTEN EIF4E RPS6 IRS1 RHEB PMC3880796__F2 TRAIL on Trial: Preclinical advances for cancer therapy CASP3 APAF1 CASP9 DIABLO FADD BAX PMC4576979__F4 Harnessing the apoptotic programs in cancer stem-like cells HEL-S-30 FOXO3A HEL-S-133P PMC11531143__F2 PIM1 enhances aggressive oncogenic characteristics in breast cancer through multiple mechanisms PIM1 BAD RUNX3 CDKN1A CDKN2B NFATC1 NOTCH1 TRIM28 CAPZA1 IL6R NOTCH3 PMC4823938__F1 Schematic overview of necroptotic pathway TLR4 TRADD IRF7 CYLD IRF9 IRF3 IRF-1 FADD TLR3 MLKL STAT3 PMC11531143__F1 PIM kinase family gene structures SOCS2 PIM1 HOXA9 PIM3 PIM2 HIF1A PMC9627168__F2 Lactate drives cellular DNA repair capacity: Role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection LDHD FFAR3 FFAR2 PMC3107442__F5 Transcripts (p < 0.05) involved in cell signaling GAD2 GRM2 GAD1 PMC8210623__F4 Analyzing signaling activity and function in hematopoietic cells TLR4 IRF3 MYD88 TNF PMC9283712__F1 TNFA Inhibitors and Other Biologic Agents for the Treatment of Immune Checkpoint Inhibitor-Induced Myocarditis TRADD TRAF2 FADD PMC5417301__F11 Model summarizing the regulation of GR by TTC5 JMY MDM2 PMC7761238__F1 Interaction of interleukin-2 (IL-2) and IL-15 with their receptors and downstream signaling pathways IL15RA IL2RA JAK3 JAK1 MTOR STAT3 PMC4587761__F3 Network associated with the proteins in CD14 TFPI C4B_2 PLG TNFAIP6 MSR1 C4A GPLD1 GHRL APOB VLDLR CPN2 APOH PMC7359176__F3 Unphosphorylated glycogen synthase kinase-3B (GSK-3B) and canonical WNT/Beta-catenin signaling in “off” state APC GSK3B LRP5 LRP6 PMC7359176__F2 Phosphorylated glycogen synthase kinase-3B (pGSK-3B) and canonical WNT/Beta-catenin signaling in “on” state APC LRP5 LRP6 PMC6795080__F1 Mevalonate pathway intermediates active in feedback control LBR FDFT1 DHCR24 HSD17B7 TM7SF2 CYP51A1 MSMO1 PMC2773299__F2 Schematic representations of the activated RAS-MAPK, RASSF1A/NORE1A, and Dab2IP/ASK1 pathways, iNOS signalling, and FOXM1-related pathways involved in the dysregulation of cell growth and apoptosis in HCC EPO FOXM1 DAB2IP NEK2 VEGFA CDC37 RAF1 CDC25B AURKA SKP2 PMC5010756__F4 Sensing of HMPV by different PRRs and modulation of the IFN response by viral proteins TLR7 TLR4 IRF7 IRF3 TYK2 MYD88 JAK1 TLR3 MAVS PMC4600616__F1 Sonic Hedgehog in SCLC GRPR SHH SMO RHO PMC4904844__F5 Interaction network of 135 SNO-modified proteins identified in WT and AD mouse brain tissues ZNF183 NDUFA2 CLTA RAC3 CS ENO1 ARHA IDH3B HEL-S-32 MDH2 PMC6281417__F7 Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation PTEN MTOR PMC8781199__F2 Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders CCT6A GSK3B HEL-S-69 HIF1A CRMP1 TCP1 CCT8 CCT4 HEL-S-94n TSC1 PABPC1 CCT7 HEL-S-100n HEL-S-133P HSPA4 HEL-S-281 PMC9527825__F1 Possible mechanisms for ANGPTL1 attenuating CRC liver metastasis TWIST2 SOX2 MMP9 PMC5742686__F3 The NLRP3 inflammasome in ORKD development NLRP3 TLR4 TXNIP IL1B PMC5535903__F2 Nucleolar response to DNA damage FBL NCL NPM1 ATM BLM RAD51 WRN BRCA1 BAX PMC3260814__F1 Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer EGFR PTEN MTOR PMC3915522__F5 Ras oncogenes: split personalities RINL RIN1 RHO RALBP1 CDC42 PMC7927090__F2 Summary of key pathways regulated by H2S donors in the treatment of CVDs HEL-S-11 ATF4 TRAF6 MTOR TRAF2 SGK1 SIRT1 STAT3 PMC2840045__F1 Innate immune responses in allotransplantation HMGB1 TLR4 PMC9557197__F1 Ferroptosis in glioma treatment: Current situation, prospects and drug applications GPX4 STEAP3 FACL4 HEL-S-64p SLC3A2 PMC6861914__F7 Apoptosis pathway in LNCaP cells treated with LEP (1 × 10−6 M) ME1 CASP6 BAD HEL-S-11 TEP1 CASP2 CAD HAT1 TRAF2 FADD HRK PMC6861914__F6 p53 signaling pathway in LNCaP cells treated with LEP (1 × 10−6 M) MYC PTEN RFWD2 TSC2 CASP3 SIAH1 AIFM2 PERP ATM APAF1 CDK2 CD2 MDM2 CASP9 CDK4 ATR PMC11278074__F1 Therapeutic approaches to vascular Ehlers–Danlos syndrome MMP9 SRC ATR PMC4502774__F1 Schematic stages of the autophagic pathway ULK1 ATG12 ATG3 SH3GLB1 AMBRA1 ATG101 ULK2 ATG10 MTOR DKFZp686F0183 PI3 BCL2 UVRAG STX17 ATG14 PMC3480285__F5 A Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis CS CCR3 ACD LAT CCR1 PMC3480285__F1 Metabolic Map of Phenolic Metabolism in the Inflorescence Stem of Arabidopsis.The main pathways involved in lignin biosynthesis are framed with a bold black border SST CS PMC4590996__F2 Biomarkers of primary open-angle glaucoma TBK1 CD14 TLR4 LBP CD44 TRAF6 IRF3 MYD88 PMC8662602__F1 Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation RIPK1 RIPK3 ZBP1 MLKL PMC4254928__F3 Insights into Molecular Features of Venerupis decussata Oocytes: A Microarray-Based Study WNT4 APC LRP6 DVL3 FZD8 PMC7367617__F3 KEGG enrichment of 249 DEGs identified between chemotherapy sensitive and insensitive OC LTA SOCS3 GADD45G FOS HBEGF CXCL3 CXCL2 TNF JUN PMC8509036__F1 B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy BAD TRADD TNF TRAF2 FADD BAX PMC4202122__F2 Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions MUC1 EGFR GRB2 RAB31 NUP62 PMC7106881__F9 Hypothetical action mechanism of aspirin on nonalcoholic fatty liver and atherosclerosis CCR2 HMGCR PMC4586018__F6 Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 TG ADRBK1 PMC6520588__F3 Schematic drawing showing proposed mechanisms of action of Curcuma longa (curcumin) APP GRAP BAX PMC6805653__F10 Molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/Beta-catenin signaling pathway in PCa CDH2 ZIC2 PMC3760627__F2 Diving adaptations in the Chinese alligator genome GNS GLB1 GGPS1 ACSL5 HBA2 PTDSS1 GGT7 ACADS SRM NDUFB10 HBB PTDSS2 SMS ENPP3 NDUFB5 CTPS2 PMC4248697__F2 Synthesis of isoprenoid products in P IPP PMC7559774__F3 tRF-Leu-CAG, ts-101, ts-46, and ts-47 are involved in drug resistance of lung cancer cells HEL-S-28 GSK3B CCND1 SRC RALB PTEN MTOR AURKA PMC3092098__F1 The genes and pathways associated with Crohn's disease pathogenesis TAGAP CARD9 ICAM3 IRGM CCL20 IL2RA MUC19 REL TGFA ICOS PMC8980325__F1 Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity COX2 COX1 SCD HEL-S-11 ARHA ACLY HMGCR PMC7395594__F6 Nrf2/Wnt/immune crosstalk in oxidative stress and inflammation in PD COX2 KEAP1 APC TNF PMC9688663__F1 Advances in Understanding of Metabolism of B-Cell Lymphoma: Implications for Therapy BTK SHMT1 DHFR MYC SRC TYMS SYK OGDH HEL-S-51e PHGDH PMC6261607__F8 Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors SMAD2 ARHA CSA2 PMC6250427__F4 Mitogen activated protein kinase (MAPK) signaling pathway MAX MYC TF PMC5109738__F5 Proposed novel caspase-1 working models NLRP3 OCEL1 PMC7335630__F2 Immunological response of SARS-CoV-2 CD47 TNF ACE2 TMPRSS2 PMC4716095__F1 mTOR signaling TSC2 TSC1 SGK1 RHEB PMC6529242__F5 Mechanisms induced by MC-GAG on osteoprogenitors and osteoclast progenitors SMAD4 SMAD1 DKFZp781O1323 PMC8841737__F2 Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor KIT IGF1R ATG2B MDM2 LATS1 PTEN MTOR PTPN18 LATS2 STAT3 BAX PMC7856198__F5 Gene identification and pathway Network Analyses of the IL-4R responsive transcripts in the metabolic MMC9 cluster TH CDA KGD4 TMEM85 MTHFD2 TUBA1A MRPS5 MCM6 TYMS MICA MRPS12 DKC1 ANKRD26 GALK2 USP22 PYCARD PMC4403665__F1 Chemotherapeutic Targeting of the Transforming Growth FactorB Pathway in Breast Cancers SMAD2 SMAD4 SRC MTOR PMC2242712__F1 Phenolic lipid synthesis in A PMC8165235__F1 Perspective: Humanized Pig Models of Bladder Cancer FGFR3 PIK3CA PTEN HRAS PMC3269833__F6 Potential regulatory mechanism of the identified gene switches for breast cancer TACSTD2 RASD1 ERBB2 CCND1 BEX2 PMC7501082__F2 Involvement of host and viral proteases in SARS-CoV-2 life cycle FURIN ACE2 TMPRSS2 PMC8493693__F4 Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis UQCRB COX1 ATP5PO ND4L COX5A UQCRFS1 COX2 ATP5MG ZNF183 ATP5MF COX10 COX11 COX7B COX7C ATP5PB SDHD SDHA COX8A SDHB COX7A1 SDHC ATP5G1 ATP6 CYB ND6 COX3 COX17 ND3 ND1 ND2 CYC1 ND5 HEL-S-123m ND4 PMC8913874__F5 How water‐soluble saccharides drive the metabolism of lactic acid bacteria during fermentation of brewers' spent grain FOS PMC10311176__F3 Transcriptome analysis of CD4+ T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity CSRNP1 CTBP2 NFE2 CXCL8 PLCG2 IGF2BP2 SOX4 OASL PAX5 ZEB2 FOSB JUNB CUX2 CREB5 SETBP1 HOXA9 FOS IRF8 VENTX ATF3 CCL4 CEBPA TNF MMP14 TBX21 EGR2 CREM KLF4 SOX5 TNFAIP3 KLF10 TNFRSF13C HOXC4 CEBPD TLR4 MSC IRF4 IL1B JUN PER1 MYBL2 EGR1 MAFB MMP9 PTGS2 LIF CXCL2 IL6 TNLG7A BCL6 NFKBIA NR4A3 TRIB1 NFIL3 CD40 MAP3K8 SYK TFEC TCF4 HHEX PMC10911341__F9 Potential mechanisms of inhibiting Perk-ATF4-P21 pathway to enhance the efficacy of MPPAlpha-PDT ATF4 EIF2A DKFZp686F0183 PMC11589783__F5 KEGG graphical of MAPK signaling pathway32 CD14 EGF MAX TRADD TRAF6 JUND KIN CDC25B REL TNF PMC3296202__F1 Pathways involved in diabetes-induced EPCs toxicity and possible strategies to reverse EPCs damage during bone marrow mobilization GLO1 CXCR4 MMP9 ROS1 PMC11589783__F6 KEGG graphical of FoxO signaling pathway32 EGF EGFR PDK2 INS SMAD4 PTEN INSR NLK CDK2 MDM2 GRB2 FOXG1 LAT SKP2 STAT3 PMC9502082__F1 RIOK3 and Its Alternatively Spliced Isoform Have Disparate Roles in the Innate Immune Response to Rift Valley Fever Virus (MP12) Infection TBK1 IRF3 MAVS PMC2923990__F7 Model for C CARD9 TLR4 BCL10 SYK MYD88 PMC2889938__F2 Target gene regulatory network, NFKB/RelA:P50 CXCL1 SOCS3 CXCL5 RELB MYC BCL2L1 GBP1 F3 BIRC3 CCL19 JUNB CSF2 IRF-1 IL1B IL10 CCL11 IRF7 MMP9 LTB CXCL2 PTPN13 IL6 TNF CD69 IL15 NFKBIA TIMP1 VCAM1 NFKB1 RELA STAT4 IL23A CXCL9 BCL2 YY1 IL15RA IL2RA SELP HLA-DMB SLC11A2 TGFB1 CCL3 PMC5645611__F1 One marker is not enough for designate one cell as cancer stem cell EPCAM CD44 CD24 PMC11637887__F3 Comparison of changes in the eye among normal, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR), and the signaling pathways of DNA methylation alterations associated with DR development TIMP1 RAC1 NR1C1 TET2 PMC11637887__F6 Impact of DNA Methylation on Schizophrenia CRH NR3C1 CNR1 GAD1 PMC4102070__F4 Points of inhibition for ibrutinib, idelalisib, fostamatinib, and Lck-i in the BCR signaling pathway BTK BASH LCK LYN PLCG2 PMC11637887__F7 DNA methylation changes in the pathogenesis of HD and the cellular impact of toxic huntingtin protein variants HEL70 SOX2 RPA3 APEX1 RPA1 BDNF BRCA1 PMC6351542__F5 S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy ITPR2 ITPKC RYR1 RYR3 FZD10 PMC4102070__F2 Signal integration following BCR engagement BTK RASGRP3 BASH LYN GRB2 PLCG2 PMC9509681__F7 Relevance of Host Gut Microbiome Signature Alterations on de novo Fatty Acids Synthesis in Patients with Multi-Drug Resistant Tuberculosis ACLY SLC25A1 PMC8964949__F6 Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness EGF ADAM8 opn MMP9 STAT3 PMC8774282__F2 Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished RET ALK FGFR3 MTOR OTP PMC3610285__F2 Melanogenesis EDN1 EDNRB PRKCB EP300 GSK3B DCT TYRP1 MAPK1 PMC2696814__F1 Autophagy in the Pathogenesis of Disease ATG12 ATG3 AMBRA1 UVRAG ATG10 DKFZp686F0183 PMC6485060__F2 CircRNA regulates cell proliferation IGF1R CDK2 APC FGF2 EGFR PTEN E2F3 CDK6 ITCH CBL PMC4104550__F1 ALK signaling pathway with its cross-talk with other pathways involved in the resistance to ALK-inhibitors BAD ALK FOS GSK3B GRB2 JAK3 MTOR PMC11549395__F5 Regulatory network of the 32 DEMs and the 66 DEM-regulated DEGs was drawn by Cytoscape 3 HAMP TTK FZD4 AURKA CDC45 WNT3 CDC20 GPC1 HOXD10 TWIST1 COL1A2 ORC1L CDC2 KNL1 ESPL1 TRIP13 PMC4092085__F2 Na+, K+-ATPase-mediated signal transduction EGFR GRB2 CSA2 PMC5406167__F6 Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster C6orf130 ASCC2 SACS CTCF TMEM208 PHF12 MOCS3 PMC3808235__F1 Pathway-guided treatment in prostate cancer PTEN MTOR AURKA PMC8596126__F8 M6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons YTHDF2 YTHDF1 FZD3 PMC9124571__F2 Immune cells in cardiac repair and regeneration IL10 CCR2 IL18 IL17A CCL7 CCL2 MERTK IL4 PMC3188704__F1 Regulation of cell migration by signaling endosomes TIAM1 EGFR SRC RHO ARF6 CDC42 PMC7986631__F1 Cannabinoid biosynthesis including polyketide and isoprenoid precursor pathways IPP H1-5 HEL-S-5 PMC2762604__F11 Proteomic and Phospho-Proteomic Profile of Human Platelets in Basal, Resting State: Insights into Integrin Signaling BTD SRC PDPK1 HEL-S-69p PMC5713906__F1 Hh signaling and how pathogens may modify pathway activity TWIST2 MUC5AC JAG2 MYC SMO IGFBP6 FOXC2 IL1B PMC4095756__F2A GRK2 – A Link Between Myocardial Contractile Function and Cardiac Metabolism GRB2 MTOR IRS1 PMC3324133__F1 Insulin receptor (INSR) belongs to a family of receptor tyrosine kinases that includes the receptor for insulin-like growth factor 1 (IGF-1R) BAD IGF2 EIF4E MTOR INSR STAT3 CAMKK2 PMC3390632__F1 Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway COQ2 CRH COG7 COG2 COQ5 COG5 COG3 PMC7369945__F1 Androgen “backdoor” steroidogenesis pathway HSD11B1 HSD3B2 HSD17B3 CYP17A1 CYP21A2 HSD17B6 PMC5209581__F5 Phosphatidylinositol 3-kinase (PI3K) pathway: Activation of class IA/B PI3Ks occurs through the stimulation of receptor tyrosine kinases, which is induced by insulin and the concomitant assembly of receptor–PI3K complexes BAD MDM2 PTEN MTOR FOXO1 PMC5960455__F1 Role of WNT/beta-catenin signaling in gliomas APC LRP5 CCND1 LRP6 HEL-S-133P STAT3 PMC7488916__F6 Working model for amplified cross-talk between CXCR4 and EGFR to promote gastric cancer metastasis EGF CXCR4 EGFR CXCL12 PMC5124975__F3 Galectin-3 and IL-33/ST2 axis interaction in diet-induced steatohepatitis IL33 PMC8835853__F1 Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis TSC2 NPRL2 TSC1 C16orf35 DEPDC5 TBC1D7 PTEN EIF4E RHEB MLST8 PMC2664745__F1 Molecular and cellular biology of enhanced cognition KIF17 CDK5 BDNF PMC5700087__F8 The proposed mechanism of BBB disruption in CNS TB SHH SMO PMC8156218__F1 Pentraxin 3: a powerful orchestrator in urinary tract infection TLR4 MYD88 PTX3 PMC6726833__F7 Functional roles of SALL4 in cervical cancer cells SALL4 APC GSK3B AXIN1 LRP5 CCND1 LRP6 PMC12000890__F1 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology TLR4 SMAD2 TGFBR1 TGFBR2 SMAD4 PMC3356080__F4 Factors and molecular mechanisms that influence ecdysone synthesis and the timing of critical weight attainment TSC2 TSC1 SMAD2 PTEN PMC12000890__F3 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology NLRP3 TRAF6 MYD88 PMC12000890__F2 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology TSC2 ULK1 RB1 PMC10379125__F5 Transcriptome-Wide Identification and Response Pattern Analysis of the Salix integra NAC Transcription Factor in Response to Pb Stress UST WAS PMC12000890__F4 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology KEAP1 SIRT3 PMC4401249__F5 DIANA miRPath analysis of target genes for miRNAs downregulated in AD blood BAD PRKCZ INS PTEN RAC1 LAMA4 MTOR CLU CDK6 RHEB TSC2 TNFSF6 PI3 BCR PDGFA GAB2 MDM2 APP SYK RBL2 CD19 PMC12024652__F1 Signaling pathway of necroptosis and its PTMs TBK1 SIRT2 PTMS ULK1 PLK1 TRADD USP21 SMYD2 RNF146 PPM1B RIPK1 CYLD APP SRC USP22 HAT1 ZFP91 PPP1R3G SENP1 RIPK3 CDC37 TNF PELI1 TRIM25 PRMT1 JAK1 TRAF2 OTULIN FADD SIRT1 SKP2 MLKL MIB2 ITCH TAB3 PMC4401249__F4 DIANA miRPath analysis of target genes for miRNAs upregulated in AD blood GRINA CREBBP PRKCB GRIA2 PMC8635864__F3 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis ALPL WNT3A RUNX2 BMP2 APC LRP5 LRP6 SP7 SMAD1 BGLAP DKFZp781O1323 PMC8635864__F1 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis ALPL RUNX2 BMP2 SMAD6 SMAD4 COL1A1 SP7 SMAD1 BGLAP DKFZp781O1323 PMC8301038__F2 Redox Regulation of Lipid Mobilization in Adipose Tissues INS NOX4 PMC9365139__F4 The effects of ATRA treatment of hyperoxic A549 cells TH TRO APP PMC3579143__F8 The regulatory role of IRAK-M in TLR-IL-1R signalling IRAK1 TRAF6 EIF4E MYD88 SOCS1 PMC10313199__F3 Advances in epigenetic modifications of autophagic process in pulmonary hypertension HDAC3 HDAC7 HDAC11 HDAC2 MTOR HDAC5 DKFZp686F0183 HDAC1 SIRT1 FOXO1 PMC7337964__F9 Expression profile of genes in Hepatic fibrosis pathway for Pre_S cohort BAMBI COL3A1 TGFBR1 TGFBR2 CXCL8 CXCL3 COL1A1 FGFR2 COL11A2 FLT1 TLR4 KDR COL16A1 COL1A2 ECE1 IFNGR1 IL10RA COL18A1 COL27A1 VEGFA TNFRSF11B IGFBP5 EDN1 IGF1 NFKB1 IGFBP4 BCL2 CSF1 PMC8064355__F7 Schematic illustrating the suppressive effect of 6M3HSC (compound 3) against the RAGE-RAGE ligand signaling pathway HMGB1 IRAK1 RHO RAC1 MYD88 TIRAP CDC42 DOCK7 PMC5464971__F7 “Tissue Development, Cardiovascular System Development and Function, Organismal Development.” This was the top most associated network according to IPA core analysis of the TM gene input set which included the microarray study by Fan et al MGP AIP ACTA2 BMP2 VCAN PPIF BMP4 GREM1 MT1E GJA1 COL13A1 SFRP1 CAV2 THBS1 SPOCK1 SMAD1 DKFZp781O1323 TGFBI PMC8762193__F1 Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly STAT1 IFNG STAT3 PMC5798893__F7 Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRB signaling pathways in tumor vascular remodeling FGFR1 PC PDGFRA FGF2 FGFR2 PMC2219351__F1 Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients SET MTCP1 DGKD EGFR GSK3B PTEN PMC7141786__F1 Proposed model for the molecular events and mechanisms underlying the protection of autophagy against alcoholic liver disease PINK1 TFEB ALDH2 PMC2323197__F1 Immunosuppression in islet transplantation IL2 IL2RB PMC7904922__F6 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications ME1 GOT2 HEL-75 HEL-S-44 HEL-S-32 MAL HEL-S-162eP GLS PMC7904922__F4 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications TSC1 SIRT6 PTEN HIF1A PMC9498834__F2 Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products HEY2 ADAM10 PMC2842525__F2 IFNA signal transduction STAT1 STAT2 TYK2 JAK1 PMC11610372__F7 Mechanism diagram of berberine acting on tuft cells to relieve colitis TRPM5 IL25 PMC12125784__F6 Working model TSC2 OMA1 PHB2 OPA1 PMC8424144__F6 How Kcnma1 regulates bone formation through Wnt/Beta-catenin signaling RUNX2 APC PMC6987096__F8 Schematic diagram that depicts platelet-induced estrogen biosynthesis in endometriosis USF2 HSD3B2 CRTC2 DUSP2 PMC9929508__F3 Microgravity and immune cells ICAM3 ATM CD80 ATR PMC2885101__F2 PI3K/Akt signaling pathway BAD IGF1 PMC3659082__F7 Insulin/IGF-1 Signaling, including Class II/III PI3Ks, Beta-Arrestin and SGK-1, Is Required in C. elegans to Maintain Pharyngeal Muscle Performance during Starvation UNC79 PMC8210242__F4 Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer ATM BRCA2 RAD51 ATR BRCA1 PMC4506602__F4 Chemical–protein interactions related to the VEGF signaling pathway PPP3CA PTGS2 PPP3CC MAPK3 MAPK14 VEGFA NFATC3 PLA2G1B PLA2G5 CASP9 PIK3CA PLA2G2A PLA2G10 PMC6378284__F6 WWOX controls TGFB, Hyal-2, and Wnt signaling pathways that cross talks with the Hippo signaling SOX2 AMOT SMAD2 TGFBR1 APC GSK3B TGFBR2 MYC HYAL2 SMAD4 LATS1 LATS2 NF2 DVL2 WWOX PMC9709458__F1 T cell function by protein S-acylation PLCG1 FYN CSK APC GRB2 LAT STIM1 PMC6378284__F4 A schematic illustration of YAP/TAZ regulation of TE and ICM specification in preimplantation embryo CDX2 GATA3 PMC6796845__F3 Core molecular mechanism of non-apoptotic regulated cell death GPX4 LPCAT3 FACL4 KEAP1 SLC7A11 NFE2L2 ALOX15 AIFM1 RIPK3 PARP1 ARHA CA9 TICAM1 GSDMD IKBKB RIPK1 PGAM5 MLKL CDC42 PMC6796845__F2 Extrinsic and intrinsic apoptosis BAK1 BCL2L1 TNF CASP10 DIABLO HTRA2 TNFSF6 APAF1 TNFSF10 CASP9 BCL2 DCC CASP8 FADD CYCS BAX PMC6345610__F3 Illustration of the role of FUNDC1-related MAMs under physiological conditions FUNDC1 FIS1 PMC4278244__F7 Model representing that Wnt/planar cell polarity signaling contributes to the association between pericytes and developing blood vessels via the Wnt5a-Fzd7-cdc42 axis PC PAH CDC42 PMC6378284__F2 Mammalian Hippo pathway signaling NF2 VGLL4 LATS1 LATS2 PMC8135154__F1 Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism NAPRT NAMPT ULK1 CASTOR1 SIRT1 RHEB PMC6667643__F2 Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis CDA PLG TNF CSF1 GAD1 STAT3 POLI PMC3502787__F1 General features of the HER family EGF BAD GSK3B HBEGF MTOR TGFA PMC6453741__F4 Functional role of CLDN1 in signal transduction and EMT in liver disease MMP2 CLDN1 PMC5644891__F1 The leptin/melanocortin pathway POMC NPY AgRP MC4R LEPR SIM1 BDNF PMC5581966__F1 The auto-immune attack to the beta-cells in Type 1 diabetes mellitus STAT1 TRADD IRAK1 APC TRAF6 MYD88 JAK1 TRAF2 FADD IFNG PMC5154833__F1 Therapeutic Relevance of mTOR Inhibition in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism TH DHH BAAT PMC3065553__F5 Metabolic pathway for pitavastatin UGT1A3 CYP2C9 CYP3A4 UGT2B7 UGT1A1 PMC8879554__F2 Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning ACO2 DLD SUCLA2 OGDH PMC5804098__F4 Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation TIGAR PSAT1 PSPH PCK2 PHGDH PMC7599793__F1 Summary of Wnt/Beta-catenin, Hedgehog and hypoxia inducible factor (HIF) pathways and their downstream mediators in the liver PIG59 IHH TWIST2 P4HA2 SOX2 GSKIP WNT9B APC LRP5 VHL LRP6 HIF1A SOX9 AHR SUFU GLI3 SHH CCND1 BCL9 PMC5445595__F3 T cell gene expression analyses of T cells from sargramostim-treated or placebo-treated PD patients RORC LRRC32 IRF8 IL24 IL6 TP53INP1 TNFSF6 IGSF6 PERP IL3 UTS2 PPARG IRF4 PMC6172014__F1 Fibroblast growth factor receptor (FGFR) structure, FGFR signaling, and specificity of the FGF–FGFR interaction FRS2 GRB2 IL1B PMC8588006__F4 Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis MYD88 TLR1 PMC12058791__F2 Natural products target ROS, P53, mTOR, NFKB, Beta-catenin and other signaling pathways to regulate apoptosis and play a role in intervening CRC CGA MTOR BAX PMC12058791__F1 Action of natural product-targeted modulation of PCD for the treatment of CRC ULK1 AMBRA1 RIPK3 ATG101 ULK2 MTOR GSDMD NLRP3 RIPK1 ATG14 FADD MLKL DFNA5 PMC3676112__F7 Translation regulation of the mTOR signaling pathway and translation process RPLP0 EIF5B RPS14 BRAF EEF2 RPL9 EIF4H EIF4E HIF1A MTOR EEF1G RHEB EIF3G TSC2 EIF3J RPL17 RICTOR ETF1 RPS13 TSC1 RPS5 RPS27A EIF4B RPL3 PMC12026011__F1 Pyrimidine synthesis pathway including the two process of pyrimidine nucleotides synthesis: the novo pathway and the salvage pathway CDA OMP CAD DHODH PMC7007431__F1 Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma PSAT1 ATF4 SHMT1 PSPH MTHFD1 FBXW7 PHGDH PMC7710720__F3 Sortilin and its soluble form (sSortilin) in colorectal cancer SRC PMC10040131__F7 PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer BPTF ANGPTL4 AQP1 VEGFA HEL-S-116 PHF6 PMC7710720__F2 Neurotensin pathway in digestive cancers and clinical applications: an overview NTSR1 EGR1 SRC NTS RHO SP3 CDC42 PMC6721562__F3 Direct and indirect epigenetic control of cellular metabolism FBP1 VHL PTEN HIF1A MTOR HK2 PMC10517567__F8 Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression FOSL1 APC GSK3B MYC CCND3 WIF1 DVL1 CCND2 LEF1 PPP2CA CCND1 DVL2 JUN BCL9 TLE2 ITCH PMC535924__F3 Molecular events shown by associated predicates GRB2 IRS1 PMC8702371__F3 Precision Nutrition Algorithm for Cancer APC PIK3CA PTEN PMC3342359__F2 Autophagy induction by TLR stimulation TLR7 TLR4 MYD88 PMC12058791__F4 Natural products play a role in intervening in CRC by targeting signalling pathways such as Nrf2, GPX4, NLRP3, RIPK1, and RIPK3 and regulating different forms of cell death mechanisms such as Ferroptosis, Pyroptosis and Necroptosis NLRP3 RIPK1 GPX4 NLRC4 STEAP3 NLRP1 HEL-S-64p RIPK3 AIM2 FADD MLKL GSDMD PMC3342359__F1 Three types of autophagy and cellular and molecular events in an autophagic pathway ATG12 ATG3 ATG10 PMC12058791__F3 Natural products target ROS, PI3K/AKT, AMPK, and LC3 signaling pathways to regulate autophagy and play a role in intervening in CRC ULK1 ATG3 MTOR PMC5824384__F1 Role and mechanism of Twist1 in renal, pulmonary and skin fibrosis BMI1 CXCL2 CXCL12 TG BRD4 PMC3410437__F2 KEGG pathway of the renin-angiotensin system CTSG CPA3 ENPEP REN CTSA NLN LNPEP ACE2 MME AGTR2 PMC7555423__F7 G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells CDK2 CCND1 CDK6 CCNE1 GPER PMC7804500__F4 PPI network of the 37 enriched genes from KEGG pathway analysis by Cytoscape HGF MAPK3 MAPK14 CCL2 HIF1A IFNG TLR4 MMP2 ATM MAPK1 NOS2 IL1B CD14 IL10 FOS MMP9 VEGFA TLR3 LEP NFKB1 BCL2 BDNF PPARG TGFB1 CDC42 PMC6773509__F2 Toll-like receptor signaling – general features of the canonical pathway IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 TIRAP PMC3826519__F8 Deregulated genes upon miR-10b overexpression in FaDu cell line FKBP6 WSB2 TCF3 TINAGL1 ETV7 PCYT1B RPL38 GML MYC PSPN HSF1 PAX4 GJB3 LRRN4 TCF23 RAX RASSF3 NHLH1 YME1L1 LMO2 MSRB1 GFRA4 PMC8745479__F1 Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease VLDLR GSK3B DAB1 CDC42 PMC8434408__F4 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells PALB2 BLM EME1 SSB MUL1 BRCA1 SYCP3 ATM BRCA2 RAD50 RAD52 REST RAD51 PMC8434408__F3 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells FEN1 NEIL2 POLE MPO MBD4 TDG NEIL3 LIG1 PCNA PMC3365728__F9 RANKL-induced actin ring organization in mature OCs TRPV4 SRC TRAF6 SYK PMC5555796__F2 Metabolic Disorder Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism CTH PARP1 NNT HEL-S-162eP PINK1 GLO1 PC F2 HEL-S-64p OGDH ACLY BDNF GLS PMC5647101__F2 The co-expressing network of differentially expressed lncRNAs and mRNAs PDE4D UTY STON2 S100A2 DES TFRC NMNAT3 ASPN PAH IRF6 BNC1 HOXD11 MCC YEATS2 MYNN LCE3D KRT13 KRTDAP hEMMPRIN PARL SPAST KRT14 ABCF3 PIGX TSLP FAT2 SBSN CSTA E2F7 TMPRSS11D GJB5 PRIMA1 GJB6 PMC8434408__F5 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells MLH3 MSH6 SSB MSH3 MSH2 PCNA PMS2 PMC10758489__F1 Metabolic reprogramming in the tumor microenvironment: unleashing T cell stemness for enhanced cancer immunotherapy HEL-S-61p MTR MTOR PMC6395542__F2 Dysregulated cholesterol homeostasis drives inflammasome activation NLRP3 ABCG1 MVK ABCA1 AIM2 PMC4712465__F1 Scheme showing role of pro and anti-inflammatory bioactive lipids in IBD HMGB1 IL4 PMC8006293__F9 Depletion of CX3CR1 leads to increased activation of the necrosome in PMNs HMGB1 CXCR1 TLR4 IL33 RIPK3 CR1 MLKL PMC3859188__F4 Pancreatic cancer initiation pathway for simulation setting (III) CHUK BAD CS MAPK8 RALA BCL2L1 RAC1 RALBP1 PIK3R4 MAP2K1 NFKB1 CASP9 MAPK1 ARAF AKT3 PMC5214937__F2 Proposed T TLR8 TLR9 MYD88 TLR3 MAVS PMC2659383__F3 SHH signaling pathway components that have been employed in the production of genetically engineered mouse models SUFU MYC SHH SMO PMC5884276__F1 Characteristic enzymes for the synthesis of isopentenyl diphosphate (IPP)/dimethylallyl diphosphate (DMAPP) and the formation of the isoprenoid diphosphate chain IPP PMC9521228__F2 Successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children MASP2 C1S PMC2958907__F1 Web-accessible DC pathway navigator RP1 RIGI TRAF2 TIRAP PMC4216593__F8 Although distal 11q copy number loss, from band 11q14 to 11qter has been reported in many types of tumors, its significance had not been investigated until our previous study () CHEK2 ATM ATR CHEK1 PMC7472658__F6 Clinical implications of PTEN loss in prostate cancer TSC2 RICTOR TSC1 PTEN MTOR IRS1 RHEB PMC4252583__F3 HDL and Cognition in Neurodegenerative Disorders ABCA1 PMC7600430__F7 Schematic diagram illustrating the proposed mechanism of (−)-agelamide D-mediated radiosensitization in HCC ATF4 EIF2A PMC11733248__F2 Current therapeutic targets in gastric cancer and GEJ adenocarcinoma DKK1 MTOR PMC4590620__F4 Alcohol’s effects on fibrogenic pathways in hepatic stellate cells (HSCs) BAMBI CD14 TLR4 LBP PMC7400404__F11 Complexin 2 in green box was mapped onto the synaptic vesicle cycle pathway (04721) generated by KEGG PATHWAY (Organism: Danio rerio) SYP PMC4590620__F2 Alcohol’s effects on pro-inflammatory pathways in liver macrophages (i.e., Kupffer cells) CD14 TLR4 LBP IL1B PMC5430631__F6 Distribution of Turkish galls target proteins on the compressed UC pathway APC FOXP3 PMC7329534__F8 Pathway analysis A) Pathway analysis for upregulated (a) and downregulated (b) miRNAs and their respective mRNA targets PIK3CD EREG PIK3R1 AP2A1 AP2A2 MAPK8 CSNK2A1 GSK3B USP33 FGFR4 EPHA8 POLR2H RDX PDPK1 PRKCA VAV3 FGFR1 PLXND1 LYPLA2 FRS2 PFN2 SPTBN1 MAPK1 FURIN COL2A1 RAB4B DAB1 AXL GRAP NTRK2 RAPGEF1 ROCK2 RELN DUSP4 ITGB3 BAIAP2 VEGFA SPRED1 EPHA7 COL5A2 IRS1 NEDD4 CALM1 UNC5A TUBA1A RICTOR RET MAPK13 SEMA6D PLXNA4 WASL DUSP16 GRB2 GRIN2B RBFOX2 BDNF DUSP3 VRK3 DUSP7 AKT3 NUMB TUBA4A HGF COL3A1 EGFR DST SHANK3 PXDN SLIT2 WWP1 INSR PLXNC1 EPN1 COL14A1 MST1R ATP6V1A EPHA4 SEMA3A DUSP9 LRIG1 PPP2R1B CHEK1 RNF41 SPTBN2 MAP2K1 PLXNA1 PLOD3 PLXNA3 MAPKAPK3 VEGFB PXN COL4A1 PMC8027215__F4 Key genes and metabolic pathways in Lokiarchaeota ACADS GCK POR ACD HEL-S-162eP PMC5829268__F2 Schematic demonstration of TCR signaling FOS ZAP70 GRB2 IL2 JUN LAT PMC4648381__F2 MGMT and other DNA repair mechanisms deal with DNA damage produced by the alkylating agent TMZ in cancer cells PARP2 PARG MPG ELL PMC11658435__F7 Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGFB/Smad2 axis in oral submucosal fibrosis SMAD2 SMAD4 PMC10778515__F6 The Rap1 signaling pathway KDR NGF NRAS GRB2 PMC9359062__F1 Anaplastic lymphoma kinase-special immunity and immunotherapy BATF3 HGF ALK TNFSF10 TNFSF13 MTOR IRF4 STAT3 PMC6456408__F7 Type I IFN signaling and production in Mtb-infected cells STAT1 IRF9 IRF3 PMC7919457__F3 Gene fusions in pancreatic cancer CDC42BPB BRAF ALK ATP1B1 PFKFB4 DNAJB1 PDZRN3 SLC4A4 CCDC6 FGFR2 COL14A1 EML4 SND1 ARAF ROS1 KANK1 RRBP1 Nbla10317 ERBB3 NTRK1 NTRK3 NRG1 RET CDH6 RAP1A G3BP2 GRB2 RAF1 TRIM24 PMC7570361__F1 Biosynthesis of steroids in mammals CYP11A1 HSD3B2 SRD5A2 HSD17B3 CYP17A1 HSD17B6 PMC8131524__F1 Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis’ Polysaccharide A TLR4 APC GSK3B IRF3 MYD88 ICOS PMC5916949__F6 A schematic depicting the potential involvement of MALAT1 in regulating inflammation through epigenetic mechanisms in diabetic retinopathy EZH2 SUZ12 EED PMC4211625__F1 Tyrosine phosphatase SHP2 is required for the proper timing of neurogenesis and gliogenesis and the balance between them during CNS development CNTF STAT1 LIF MYC GRB2 STAT3 PMC8699088__F2 Senescent Cells in Cancer: Wanted or Unwanted Citizens CGAS IL1R1 MTOR GATA4 PMC6047270__F1 Cell cycle arrest induced fibrosis ATM CDK2 CDK4 ATR TGFB1 CDK6 PMC7311088__F1 Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation–Defluorination Pathway TH ENO1 PMC6167191__F5 Dendritic Spine Elimination: Molecular Mechanisms and Implications CXCR1 CDK5 ARHA MEGF10 MERTK EPHA4 PMC11039819__F2 Interplay between autophagy and cGAS-STING signaling and its implications for cancer TBK1 CGAS IRF3 IFNB1 PMC1483059__F10 Peculiar structure of the juxtanuclear actin network SRC ARHA RAC1 CDC42 PMC3763461__F1 Hypothetical model explaining the pathway through which mutated htt (mhtt) causes OMM permeabilization BAD BNIP3 BDNF OPA1 PMC6584619__F8 mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGFB1––induced collagen biosynthesis PSAT1 ATF4 PSPH HEL-S-51e PHGDH PMC8392056__F1 Molecularly Targeted Therapies for Gastric Cancer. State of the Art HGF EGFR MTOR PMC7997471__F5 Proposed mechanism is depicting the effect of IMP inhibiting inflammatory effects STAT1 CD14 TLR4 KEAP1 LBP HEL-S-44 MYD88 JAK1 STAT3 PMC4739752__F1 Repression of DNA-damage signaling pathways at telomeres MAD2L2 RNF168 RIF1 ATM MDC1 RAD52 RAD51 PARP1 ATR H2AX XRCC3 POLI PMC3924780__F1 Scaffolding Proteins: Not Such Innocent Bystanders PLK1 GSK3B LRP6 CDC2 PMC3432564__F2 Transmembrane CLRs involved in antifungal immunity and their intracellular signaling pathways CARD9 SYK RAF1 MYD88 PMC6167191__F7 Dendritic Spine Elimination: Molecular Mechanisms and Implications BAD ARC BDNF BAX PMC3518628__F1 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS PIGO APC PMC3252742__F4 Apoptotic pathway in cardiac myocytes CASP3 BAD CASP9 DIABLO BAX PMC3518628__F3 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS AXIN2 IFNG POLI PMC11760468__F1 Ras signaling and its involvement in myeloid malignancies NF1 BAD GAB2 GSK3B GRB2 EIF4E FLT3 MTOR MPL PMC6317740__F1 Dishevelled: a masterful conductor of complex Wnt signals LRP5 LRP6 RHO CDC42 PMC4573074__F1 Regulation of autophagy.Notes: mTOR is one of the most important regulators of autophagy ULK1 ATG12 ATG3 BCL2 ATG101 PTEN ATG10 DKFZp686F0183 PMC4056054__F1 Co-culture with M38 melanoma upregulate interferon signalling pathways STAT2 FOS MSC IRF-1 IFNG PMC3084393__F10 Proposed diagram for Alpha-mangostin-induced apoptosis in COLO 205 cells BMF PMC4013479__F1 A simplified working model of the c-di-GMP signaling pathway in B RRP1 HK2 PMC7353358__F2 Phytochemicals activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway AHR KEAP1 PMC4534795__F12 Selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression TH NRF1 CP PMC6888825__F7 Proposed transcriptional regulatory system for VA and SA catabolism in Sphingobium sp PDC LIG1 MGA PMC7497066__F1 Frequent mutations in positive (green) and negative (red) regulators of the NF‐KB pathway in MM BCL10 BCR TRAF5 CYLD TRAF3 RELB TRAF6 CD79B TRAF2 CD79A LTBR PMC2741634__F2 How location governs Toll like receptor signaling TLR4 TRAF6 MYD88 TIRAP PMC11909974__F10 Integrative analysis of transcriptome and metabolome reveal molecular mechanism of tolerance to salt stress in rice KL MAL PMC9125221__F6 Identification of Candidate Genes Associated With Tolerance to Apple Replant Disease by Genome-Wide Transcriptome Analysis RGL3 LEP RGL2 PMC6738915__F6 Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae MAF KEAP1 RBX1 PMC7393266__F2 Major anti-tumor mechanisms of EGFR monoclonal antibodies CDK2 EGFR H2AX TF BAX PMC3616148__F2 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability REV1 POLN RAD18 PCNA USP1 PMC7359322__F6 Heat map and DEGs expression profiles of genes associated with phenylpropanoid biosynthetic pathway, (B) heat map showing the different expression profiles of genes involved in the terpene biosynthesis pathway ME2 MVD MVK CAD IPP MVP PMC3616148__F3 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability REV1 FAN1 FANCD2 SLX4 EME1 ERCC1 PMC6215570__F6 Akt/mTOR pathway and regulatory effects of galangin and pinocembrin on the phosphorylation of key proteins TSC2 PTEN RPS6 MTOR PMC3266773__F10 CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression LEF1 CD27 TNIK RUNX1 BCR TNLG8A VEGFA TRAF2 PMC3762088__F2 Regulation of autophagy by oncogenes and tumor suppressors TSC2 TSC1 BCL2 PTEN PMC5700962__F8 Parkinson disease pathway(red, up-regulated) TH SNCA F2 HTRA2 RFWD2 PMC5700962__F7 Six genes are enriched in the top 2 significant pathways(red, up-regulated) EDAR LEP KIT EPO BMP2 LTB TPO LEPR TNLG7C PRL ACTR2 PMC7450308__F1 Increasing ROS triggers mitochondrial damage related to ferroptosis under cysteine starvation GPX4 TF PMC2822975__F1 Asbestos has pleiotropic effects on cell signaling pathways TSC2 TRADD EGFR PTEN MTOR PMC9475360__F2 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer GRB2 LATS1 MTOR PMC9475360__F1 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer GRB2 SOS1 MTOR PMC10491753__F5 Pictorial model of intracellular redox balance facilitated by compartmentalization of amino acid biosynthesis enzymes within optimally sized peroxisomes GPD2 GPD1 PMC5771206__F6 Intramuscular fat metabolism LPL CPT2 HEL-S-104 THRSP PMC10242330__F2 Autophagy: A challengeable paradox in cancer treatment TSC2 TSC1 AMBRA1 BCL2 ATG14 RHEB PMC7646705__F1 Schematic outline of lipid oxidation and impaired lipoprotein metabolism in psoriasis ABCG1 LDLR PON1 PMC8972277__F5 Aspirin attenuates liver fibrosis by suppressing TGFB1/Smad signaling SMAD2 SMAD4 PMC6444613__F1 Metabolic pathway of propionyl-CoA and methylmalonyl-CoA LMBRD1 MTRR CBLC MMADHC PMC4453439__F1 The signalling pathways implicated in fusion-positive ARMS progression IGF1R IGF2 PAX7 FGFR4 PTEN PAX3 FOXO1 PMC3088722__F6 Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells NDN CDKN2D TBX2 CTCF PRIM2 EI24 DDB2 CASP2 LATS2 GAS2 CKS1B TP53INP1 CDKN1A HEL-S-76p CCNG1 CDK4 CRADD CLIC4 PEG3 BIRC6 ZNF346 RBL2 PTP4A3 TGFBI PMC7606576__F3 WNK/SPAK/CCC signaling pathway in cell volume homeostasis WNK3 WNK1 OSR1 PMC3672665__F1 Epithelial cancer cell inflammatory response CYLD PTEN STAT3 PMC3842443__F2 Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy TSC2 TSC1 HGF ERBB3 RHO RAC1 IRS1 RHEB CDC42 PMC5987629__F1 Schematic diagram of the heterologous synthesis pathway for the production of geranyl acetate in the engineered S IDI1 MAF1 IPP PMC10526800__F3 Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond FLOT1 PCSK9 IGF1R IGF1 CKAP4 LRP5 LRP6 PTEN DKK1 MTOR PMC8557215__F7 Schematic drawing of LPS function in PDAC TLR4 LBP MYD88 PMC9133627__F1 Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses CGAS STAT2 IRF7 IRF9 TRAF3 TYK2 IFNAR2 MAVS PMC3071831__F7 Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures TSC2 FLI1 RICTOR TSC1 IGF1R IGF1 PTEN MTOR RHEB PMC6328873__F1 State of art of neutrophil extracellular traps in protozoan and helminthic infections TLR4 MPO HEL-S-11 IRAK4 TRPM2 PMC7779655__F5 Copper-dependent mechanisms of cancer cell migration and metastasis ATP7A ATOX1 CCND1 SRC PMC2749862__F5 Most prominently affected gene network in response to DEX in TM 86 cells ZFP91 ARMC8 BCLAF1 NKTR PRPF4 PMC7779655__F4 Copper-dependent mechanisms of oncogenic signaling ULK1 ULK2 MTOR PMC5024694__F1 Simplified model of the canonical Wnt pathway and inhibitors APC GSK3B LRP5 LRP6 MTOR BCL9 PMC2749862__F6 Most prominently affected gene network in response to FA in TM 93 cells OIP5 LIMCH1 UBR7 MT1E PIR CDCA3 TMEM14A ANKRD36B PMC7794785__F5 Activation of MAPK pathways (highlighted in yellow), the guanyl cyclase pathway (highlighted in orange) and nuclear factorKB (highlighted in purple) by the adenosine A1 receptor (A1R) GRB2 PREX1 PMC7779655__F1 Cellular copper homeostasis in mammals LOXL2 LOXL3 SCO2 LOXL4 SLC25A3 COA6 ATP7B FAM36A COX17 DBH ATP7A ATOX1 COX19 HEL-S-44 COX11 LOXL1 CP CCS COA5 PMC10836028__F9 Schematic figure showing that melatonin attenuates mechanical trauma-induced hepatic injury by inhibiting IP3R1-mediated MAMs formation via activating the melatonin receptor-ERK1/2-FoxO1 pathway FOXO1 PMC4851740__F3 Schematic model of signaling pathways implicated in tumor cell VM NOTCH4 MMP14 MMP2 NODAL TWIST1 EPHA2 TF PMC2693232__F2 Unifying model of TGFB signaling in breast epithelium SPARC IGF1 CD44 TGFBR2 CAV2 HEL113 CDH2 TGFA CD24 PMC4614799__F1 Driver genetic lesions in papillary thyroid carcinoma PTEN MTOR PMC7581770__F2 Pathway annotation analysis of AVNFH patient cartilage transcriptomics and RANKL induced osteoclastogenesis transcriptomics MAP2K6 MTHFD2 LMBRD1 ADI1 MRI1 TPMT PAPSS2 GCLM CTSK FOS SLC46A1 TNFSF11 TRAF1 DHFR CDC42 MTHFD1L CTRB2 HEL-S-302 SLC25A32 CTRC NNMT RELB TFRC CALCR MTOR AOX1 SLC44A1 CUBN TRMT112 CTH PRSS1 MMAA MMACHC TCN2 RAC1 MTHFD1 HEL-S-21 AMN MMADHC TCIRG1 CBL ABCD4 NFKBIA MAP2K1 ENOPH1 FHL2 ABCC1 LYN TRAF2 MCOLN1 PIK3R2 PMC6017457__F3 Schematic representation of the unfolded protein response pathway ATF4 EIF2A PMC2690394__F2 Molecular targets of natural chemopreventive agents MDM2 GRB2 PTEN PMC5557355__F7 Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis MTOR EN2 EN1 PMC8721012__F5 New Antitumor Direction: Tumor-Specific Endothelial Cells HSPA12B FGF2 GSK3B CCL2 MTOR CCL22 PMC6522317__F2 Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis FLI1 HEL-S-99n MPL PMC8536918__F1 Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy SUFU SMAD2 APC EGFR SMAD4 SMO PTEN PMC2627788__F5 Wnt/Beta-catenin signaling pathway in leukemia SALL4 APC GSK3B LRP5 LRP6 PMC3314429__F2 miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma EGFR PTEN STAT3 PMC3663800__F8 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer EGF ERBB2 E2F2 EGFR MDM2 FGFR3 CCND1 CDK4 E2F3 PMC5154738__F2 Translational Control of Long-Lasting Synaptic Plasticity and Memory TSC2 RICTOR TSC1 PTEN MTOR IRS1 RHEB PMC7105607__F2 Impact of NFKB on MS animal models RELB ELL PMC7105607__F1 NFKB signaling cascade TLR4 BCL10 TRAF3 RELB TRAF6 CD40 TNF TRAF2 TAB3 PMC3663800__F7 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer PLCG1 PRKCZ PRKCE EGFR NNT PLCG2 SHC3 SPHK2 PRKCA MAPK1 PRKCI PRKCQ PDGFRA SOS2 FGFR3 MAP2K2 SHC2 DAPK2 RASSF1 MAP2K1 PRKCB GRB2 SHC4 SPHK1 RAF1 SOS1 PRKCH SHC1 PMC6558796__F3 Gene network analysis of RNA-Seq data from MDA-MB-231 and OVCAR3 cells IFIT3 PARP14 IFIT2 POM121 TDRD7 SKA2 IFIT5 THEMIS2 MX1 DEPDC1 OAS3 XAF1 CCND1 GINS2 IRF2 PDCD10 NUSAP1 CKS2 RSAD2 STAT2 APC SPRED1 CDCA8 KIF20A TYK2 JAK1 SMC4 PCNA SKP2 IFIT1 PMC4227170__F2 CD147 plays an important role in a variety of cells and tissues regardless of health or disease GC EGFR CD44 ABCG2 TNF PMC11718844__F2 Signaling by IL-23R RANBP1 STAT4 SATB1 TYK2 IL23R SGK1 FOXO1 STAT3 FOXP3 PMC6381934__F1 Metabolic pathways of 1,25(OH)2D and 27HC synthesis CYP27A1 CYP2R1 CYP24A1 CYP7B1 CYP27B1 PMC11718844__F5 Key approved pharmacological agents for the IL-23R pathway TYK2 IL23R PMC8052535__F1 Proteolysis and inflammation of the kidney glomerulus C9 C4B_2 MASP1 C7 C6 C1S C4A PMC8439382__F1 The UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder ATF4 EIF2A PMC3645655__F3 P53 and BRCA regulation of DNA repair represents a central component of altered cellular function in serous ovarian cancer ID4 MYC RAB25 CSMD3 PTEN SPARCL1 RB1 BRCA1 FAT3 CCNE1 NF1 ATM BRCA2 EVI1 RAD51 ATR AMT WWOX PAX8 PMC5433029__F1 Hypothetical schematic of the physiological and pathophysiological roles of Notch signalling in articular cartilage NOTCH2 RBPJ ADAMTS5 IL1RL1 NOTCH1 ADAM10 PMC7651136__F4 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer WEE1 ATM FOXM1 CDK2 CDC2 ATR PMC5700962__F9 Breast cancer pathway(red, up-regulated) KIT APC EGFR SHE CDK4 PTEN PMC3217209__F1 Insulin Resistance, Hyperglycemia, and Atherosclerosis APOB VCAM1 PIR MTOR PMC7651136__F7 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer HMGB1 TLR4 EGFR XPC IRF3 ATR CPD PMC7651136__F9 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer MYC PTEN MTOR PMC4735799__F8 Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system EGF AREG EGFR PMC8590697__F7 Graphical abstract of the mechanism by which cetuximab enhances RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 axis through the activation of p38 MAPK EGF GPX4 EGFR PMC8704271__F1 Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model TPM1 PLEKHH2 DOCK10 GPR49 MTOR E2F3 KSR1 UBA7 SCAND3 SERPINB2 KIF25 SGK1 HEL-S-117 PTGDR KRT14 SCN3A KIRREL3 MMRN1 CYTL1 PDC CLSPN BEX1 CKAP2 CXCL12 ATR JAM2 PMC6683007__F7 Molecular mechanisms associated with acylcarnitine expression in substantia nigra 3 days post-TBI HMGB1 TLR4 GPR158 PMC8138567__F2 Curcumin as a Potential Treatment for COVID-19 EGFR MTOR ACE2 ADAM17 TMPRSS2 STAT3 PMC6584345__F4 TRAIL death receptor pathway and its regulation by bioactive peptides MEI1 PLVAP MCL1 FADD PMC6972648__F5 Evidence for a role of protein phosphorylation in the maintenance of the cnidarian–algal symbiosis CRX TSC2 AMFR VCP PMC6584345__F3 STAT3 signaling pathway and its regulation by bioactive peptides SHE MTOR STAT3 PMC8622906__F5 CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes TH CSF1R CD40 CD40LG PMC5778467__F7 Biological pathways that engage TDP1 and TDP2 SSB PARP1 PNKP TDP1 PMC11350665__F7 Main biological pathway responses to acute Cd exposure in oysters ABCC3 LAP3 CD2 MGST3 ABCA1 ABCB1 FASN PMC6343200__F5 Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors MEPCE SUV39H1 LARP7 SMYD2 RELA EZH2 SP1 CDK9 L3MBTL1 BRD4 PMC8750274__F2 Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer ULK1 FLCN ATG12 CDK5 DKFZp762B153 DKFZp686F0183 CDK6 TSC2 TFEB CDK2 CDK4 CDC2 UVRAG BNIP3 ATG9A ATG14 GABARAP PMC9545958__F8 LncRNA AK018453 regulates TRAP1/Smad signaling in IL‐17‐activated astrocytes: A potential role in EAE pathogenesis SMAD2 SMAD4 TNF PMC9229972__F3 Network Approaches to Integrate Analyses of Genetics and Metabolomics Data with Applications to Fetal Programming Studies HEL-S-62p ACCS CS GC SLC16A9 PMC9501218__F5 MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells TLR4 TLR3 PMC4107945__F1 RLR signaling pathway is shown TBK1 USP21 IRF3 TRIM25 MAVS PMC3620110__F6 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß ASF1B MYBL2 BIRC5 INCENP CENPF TOP2A PRIM1 AURKA CDCA8 AURKB CDC45 GADD45B GIG8 MCM2 CDKN1A WDR76 CDK14 CCNB2 CCNB1 MCM10 CDC2 CDT1 PCNA RBL1 PMC3944254__F5 Proposed model of hypoxia-induced cellular processes presumably leading to antifolate resistance DHFR CAD FPGS PMC8820521__F2 Introduction to DOK2 and its Potential Role in Cancer EGF CSK EGFR SRC MTOR PMC12096540__F1 Key reactions involved in glycerolipid synthesis in plants PC LPA GAL PMC4384471__F4 Induction of interferon (IFN) and its antagonism by viral proteins CGAS IRF7 IRF3 MAVS PMC8495158__F2 Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells LEP PC APP PTEN POR COMP PMC4384471__F2 Interferon (IFN) signaling via the JAK–STAT pathway IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IFNLR1 PMC11989373__F2 AMPK signaling pathway in brown adipocyte thermogenesis UCP1 ADRA1A TFAM PMC6783260__F1 Complement activation triggers neuronal damage HEL-S-62p NGF PMC3620110__F2 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß FST CXXC5 ASAP1 MCAM NEDD9 HEL-S-116 SMAD1 TGFBI GATA3 INHBA TSN TAGLN PMC5065109__F2 Current hypotheses for IFNGamma-mediated effect on NSPC activity.Notes: IFNG binds to the IFNG receptor (IFNGR1 and 2) and activates Janus-activated kinases 1 and 2 and signal transducers and activators of transcription-1 (JAK-STAT1) pathway STAT1 SHH IFNGR2 JAK1 IFNGR1 IFNG STAT3 PMC5682975__F5 Proposed model of IRAK4 regulation of TLR7/8 signaling pathway in human monocytes is shown TLR7 TRAF6 IRAK4 IL6 MYD88 TNF PMC11240352__F1 Genetic and nongenetic mechanisms of CRC resistance to cetuximab IGF1R HGF BRAF EGFR PTEN PMC9455954__F9 Comparative Physiological and Transcriptomic Analyses of Two Contrasting Pepper Genotypes under Salt Stress Reveal Complex Salt Tolerance Mechanisms in Seedlings COPE PROC ERF PMC11083860__F8 FGF23/FGFR1cAklotho signalling pathway which mediates phosphorylation of NHERF1 FGF23 FRS2 GRB2 SOS1 SGK1 NHERF1 PMC3000288__F1 Schematic representation of the As cycle in the environment and plants PC SI ABCC1 ABCC2 PMC7396444__F4 Expression of DEGs involved in the apoptosis and autophagy signaling pathways INS CAD FADD HRK PMC1974867__F9 Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis VIP CFTR PMC11240352__F4 Cetuximab mechanism of action and summary of how RAC1 and RAC1B could contribute to the known mechanisms of cetuximab resistance in CRC MMP3 PAK1 IGF1R EGFR RAC1 PMC7569177__F9 Cell Cycle Pathway from the KEGG Pathway hsa04110 PLK1 GSK3B SMAD4 CDK7 ORC2 CDC20 CDK2 MDM2 ORC1L CDC2 RAD21 PCNA SKP2 PMC6267225__F2 Core analyses network predictions for HBoV-infected CuFi-8 cells AKAP12 NEDD9 PLA2G6 SERPING1 NFKBIZ RPL13 ARHGEF2 THBS1 SIX2 FOXO1 CNNM4 PMC9693457__F2 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia EGF BCR EGFR PMC9693457__F1 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia BTK SYK PLCG2 MTOR PMC5553878__F6 Proposed model by which CCR7 regulated NFKB/VEGF pathway and induced angiogenesis in esophageal squamous carcinoma cells VEGFC CCR7 VEGFA PMC9687478__F1 Antiviral Innate Immune Responses in Autoimmunity: Receptors, Pathways, and Therapeutic Targeting TBK1 CGAS TLR9 IRF7 IRAK1 IRAK2 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 MAVS PMC6038164__F1 RhoA/ROCK1/LIMK2/Cofilin signaling pathway LIMK2 ROCK1 ARHA PMC7223178__F1 Mammalian TLR signaling pathway TBK1 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TNLG7C TLR10 TLR3 TLR8 LTA TLR7 TLR4 TIRAP PMC5474286__F1 Schematic representation of the immune cells involved in Mycobacterium tuberculosis infection HEL-S-92n CD80 IL1B PMC5915337__F4 Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer TIGAR EEF2K SMAD4 PTEN EIF4E INPP4B IRS1 CCNE1 TSC2 TSC1 MSH6 CCNB1 NOTCH1 SRC IGFBP2 RAD51 CDK4 PCNA PMC4057133__F6 Summary of signaling events leading to PRKD2-dependent induction of senescence in p53wt and p53mut GBM cells CDK2 CCND1 CDK4 PRKD2 PMC4523434__F1 Endoplasmic reticulum quality control in cancer: friend or foe SEL1L OS9 XBP1 PMC3913938__F7 Suggested mechanisms of synergistic cytotoxicity of [Gem+Clo+Ed] combination in lymphoma cells based on the previously reported data and our present results CASP3 ATF2 CASP9 CASP8 FADD PMC2233667__F6 Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens CS PC POR PMC11174978__F3 Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury MMP7 MMP14 COL3A1 SMAD2 APC GSK3B COL1A2 SMAD4 COL1A1 PMC7751853__F6 Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells STAT1 IL1B FADD PMC8986524__F3 Molecular mechanisms underlying the emergence of polygenetic antifungal drug resistance in msh2 mismatch repair mutants of Cryptococcus VPS16 VPS39 SNX3 PMC1560097__F3 Light-cycle of rhodopsin MAX PMC4914571__F5 Gene of the month: SMARCB1 CDC6 MYC PMC8976844__F6 Mechanism graph of the regulatory network and function of miR-30c CD44 BCL9 PMC7987693__F1 TGFB signaling pathways in EMT MMP2 SMAD2 ZEB2 MMP9 GRB2 SMAD4 TRAF6 ARHA RAC1 CDH2 MTOR CDC42 PMC309045__F1 CRP-dependent (A) and CcpA-dependent (B) carbon catabolite repression pathways and the Ntr regulatory pathway (C) HP CRP HPR PMC6923180__F6 Schematic diagram of the pathway for OXT inhibition of CRC metastasis OXTR CCL2 OXT PMC6362084__F5 Activated TLR4 signal inhibited by neurosteroids HMGB1 TLR4 TRAF6 MYD88 PMC4785873__F3 Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons BRF2 CSTF2 KRTCAP2 PFDN1 PHC1 HNRNPUL2 SRSF6 NOC2L PGRMC1 ZNF277 PMC6798880__F2 Oncogenic KRAS effector pathways TBK1 GRB2 RALB MTOR AXL PMC8603983__F3 Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs KEAP1 PRXL2A TUG1 PMC7300384__F2 Epigenetic and epitranscriptomic pathways depend on metabolism HEL-S-26 NAMPT PDC SIRT4 NMNAT2 HDAC7 ACSS2 GPS2 ACLY HDAC1 TET2 SIRT3 PMC5091819__F1 Fronto-striatal circuits originate in the frontal cortex and pass through the basal ganglia, which project via the thalamus back to frontal brain areas PDE1B GC PMC5524517__F1 Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia SPARC KIF23 F2R PLAUR EPCAM COL3A1 MMP9 VCAN PDIA4 MYC TFRC CLDN2 COL1A1 IFITM1 CEBPB MMP14 TIMP1 VCAM1 CLDN7 CHI3L1 ICOS STAT3 PMC3146054__F2 Regulation of microsomal triglyceride transfer protein PDK2 MTTP INSR PMC9705465__F3 Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases DAO ETHE1 SUOX PMC4259167__F1 Anti-tumor functions of GD T cells CXCL13 MICB MICA CD40 CD83 PMC3039688__F7 Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts SOCS2 SOCS3 STAT2 IRF9 IFNGR2 IFNAR2 IFNB1 IFNAR1 SOCS6 IFNG STAT1 PTPRC TYK2 PTPN6 JAK1 IFNGR1 SOCS5 SOCS1 STAT3 PMC7002987__F1 Different signaling pathways regulating melanogenesis HGF MC1R PMC5483589__F5 Ror2-expression-responsive module PRKCZ PPP3CA FLNA CREB1 CEBPB TEAD3 BCL10 NFYC DVL2 ROR2 FURIN MED30 PER2 MAPKAPK2 ACTG2 CSK MAPK10 NR3C1 ADFP ATP6AP2 ADCY3 HEL-S-130P CTSZ PLCB4 UBE2C MAPK13 HEL-S-273 AQP2 F7 MAPKAPK3 ABCA1 NPAS2 MME RPS6KA2 CD36 PMC7402354__F2 Platelet signaling pathways that trigger ROS production COX1 LYN SRC SYK TRAF4 CD36 PMC3829165__F9 Schematic illustrating the signaling pathways for TGFB1-induced down-regulation of VE-cadherin and the inhibition of cell invasion in human trophoblast cells SMAD2 SMAD4 PMC9231053__F6A Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR XK BOK PMC7002987__F3 Cytokines that inhibit or stimulate melanogenesis IL33 TNF IL1B PMC2794709__F2 O-GlcNAc and phosphate regulate the insulin signaling pathway at the plasma membrane OGT IRS1 PMC9340222__F2 Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms NLRP3 MTOR PMC9464648__F2 From cerebral ischemia towards myocardial, renal, and hepatic ischemia: Exosomal miRNAs as a general concept of intercellular communication in ischemia-reperfusion injury AGO2 DGCR8 DROSHA HNRNPA2B1 PMC5271383__F2 Regulatory mechanisms of NLRP3 inflammasome assembly NLRP3 BRCC3 PMC11689543__F5 Inflammatory and immunoregulatory role of megakaryocytes in sepsis HMGB1 TH CGAS IFITM3 IL6 RHO TSLP GSDMD IFNG NLRP3 PDC TLR4 CXCR4 IL33 CCR7 RHOB PMC9686310__F6 A muscle cell and the proteins linked to protein turnover and quality control BAG3 SQSTM1 TRIM32 LAMP2 DNAJB6 KIAA1632 SIL1 VMA21 PMC11689543__F3 Enhanced thrombopoiesis in sepsis ANGPTL4 TPO STAT3 PMC10143456__F7 Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic Kidney Disease LRP5 LRP6 DKK1 PMC12170861__F4 Distribution of common targets in the main signaling pathways PLN ChAT TNC PI3 BCR DDC DAO HRC MCU TRDN CERK PMC5590044__F6 Schematic of anti-EMT pathway of Rb1 EP300 RB1 PMC9254539__F2 Lipid metabolism in tumor microenvironment: novel therapeutic targets SQLE PMVK MVD MVK PTEN HMGCR PMC6997842__F1 Brain-derived neurotrophic factor (BDNF) mediation in the anti-inflammatory and neuroprotective response of Alpha-melanocyte-stimulating hormone/melanocortin 4 receptor Alpha-MSH/MC4R against damage produced by excessive alcohol consumption BAD BDNF IL1B PMC11387119__F3 Inflammasome sensors have diverse roles in tumorigenesis NLRP3 NLRC4 NLRP6 MUC2 AIM2 STAT3 PMC6988351__F8 Inflammasome pathway CRP HEL-S-92n IL1B PMC9301571__F2 Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming SAG SHH MTOR PMC4215754__F3 KEGG B cell signaling pathway tuned in CD19 B cells and CD4 T cells CHUK GSK3B PLCG2 BTK VAV3 BCL10 BASH MAPK1 CD19 FOS RAC1 HRAS CD79A CARD11 CD72 PRKCB NFKB1 CD22 LYN GRB2 SYK RAF1 CR2 SOS1 AKT3 PMC4215754__F2 Visualization of KEGG B Cell Receptor Signaling Pathway after parsing and automatic correction CHUK FITM1 FOS GSK3B HRAS CD81 IKBKB NFKBIA BTK CARD11 VAV3 CD72 BCL10 BASH NFKB1 CD22 LYN GRB2 SYK RAF1 CR2 CD19 AKT3 PMC8670018__F1 T cell-associated tissues and T cell activation by RANKL-RANK-OPG LTA TRAF6 CD40 AIRE LTBR PMC3584666__F1 Toll-like receptor (TLR) signaling pathway TBK1 TLR5 TLR9 IRF7 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR8 TLR7 TLR4 MAL PMC4215754__F4 KEGG B cell signaling pathway after tissue specific and PPI-based tuning in CD19 B cells CHUK SOS2 HRAS IKBKB NFKBIA CARD11 NFKBIB NFATC2 CD72 BCL10 COPE BASH NFKB1 CD22 GRB2 PIK3CA SYK RAF1 SOS1 VAV2 PMC8474727__F6 ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells PLK1 ATM HEL-S-87p PMC9339679__F3 Ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction CD44 EZH2 USP44 USP22 PMC3366009__F8 T cell signaling pathway used by A2 and A9 ZAP70 SYK GATA3 IFNG PMC11995686__F3 NFZ signaling pathway diagram USP21 ERG BCL2 STAT3 PMC4622601__F1 Mechanism that result in aberrant Wnt/Beta-catenin signaling in colon cancer APC SFRP1 PTEN PMC2943975__F1 TOR signaling never gets old: Aging, longevity and TORC1 activity TSC2 EEF2K TSC1 EEF2 VHL EIF4E HIF1A MTOR EIF4B STRADA RHEB MLST8 PMC8301407__F3 Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway IDO1 KMO IDO2 PMC5928365__F7 Ror2‐dependent noncanonical Wnt signaling LRP5 LRP6 ROR2 SIAH2 PMC3287362__F1 The anatomic and molecular mechanisms of sepsis-mediated sympathoexcitation and ghrelin's anti-inflammatory effect via sympathoinhibition TLR4 NTS ARC PMC8408949__F1 Biology of bone morphogenetic protein signaling pathway in cerebrovascular system SMAD4 SMAD1 TF DKFZp781O1323 PMC4822108__F3 Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer KAT2B E2F4 TAF10 ING3 MYC TRRAP BRCA1 tal-1 ACTL6A NR1i1 MAX ENY2 SCA7 USP22 OFD1 PMC5674948__F5 Summary of age, BMI, and differential correlation results (a) BMI and age independently increase inflammation in adjacent normal tissue (arrow) DCN FAP GATA3 FGF7 PMC5934344__F1 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy DAAM1 ROCK1 APC GSK3B ARHA PMC3039927__F1 Organellar Ca2+ buffering and intracellular Ca2+ dynamics HRC CA4 ORAI1 STIM1 PMC8998661__F2 Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders ROCK1 MSC LRP5 LRP6 ARHA LPA DKK1 DMP1 PMC5934344__F3 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy DAAM1 ROCK1 ARHA NOS1AP PMC5934344__F2 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy DAAM1 ARHA PMC3874981__F5 NELL-1 signaling pathway NELL1 LEF1 APC LRP5 SMO PMC3874981__F4 Schematic of Hedgehog signaling pathway GLI3 SMO PMC5297831__F2 The mTOR signaling pathway TSC2 TSC1 PTEN RPS6 DEPTOR RHEB PMC4614341__F1 Schematic of signaling pathways involving the DNA damage response (DDR) pathway in apical and basal cells in the developing neuroepithelium ATM MDM2 ATR PMC7249467__F5 Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury BAD GRB2 ARHA HRAS PMC7046546__F3 Signaling due to A APELA MIP IFNG PMC8607366__F3 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury APC NOTUM GSK3B LRP5 LRP6 WIF1 PMC4657327__F2 FA/BRCA pathway and crosstalk between FA and other DNA repair pathways ATM RAD50 RMI2 RMI1 ATR MRE11A PMC8607366__F2 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury NRG1 LATS1 LATS2 PMC3874981__F3 Beta-catenin dependent and independent Wnt signaling pathways LEF1 APC LRP5 ROR2 RHO PMC4391727__F5 Differentially expressed genes related to BMP signalling at day 0 to 3 of arthritis in comparison to non-induced controls FST BMP3 BMPR2 RUNX2 SMAD2 SMAD4 EMP2 BMP7 BMP4 PMC7263055__F2 Establishment of type 2 inflammation in ECRS CCL11 SPINK5 IL33 IL25 TSLP PMC7335243__F3 Possible viral entry and replication mechanism of SARS-CoV-2 ACE2 PMC9231053__F5A Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR GPT PMC8435728__F4 RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report BAD BRAF EGFR MAPK3 NRAS MYC MTOR CRKL PDGFA MDM2 CASP9 DVL2 KITLG ARAF KIT SOS2 FOS HRAS CRK NFKBIA GRB2 BCL2 FLT3 CBLC SKP2 CYCS AKT3 PMC3827358__F8 Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway TLR4 CAV3 NEDD4 PMC7567113__F8 BNip1-mediated apoptosis in photoreceptors USE1 STX18 SEC22B KIF3B BCL2 BNIP1 BAX PMC4404867__F1 Coagulation, anticoagulation and fibrinolysis maintain a delicate physiological balance between bleeding and thrombosis TFPI PLG VTN TF PMC3767435__F2 Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia NFKBIL1 LY86 MAPK8 IRAK1 IRAK2 MAPK14 TRAF6 IRAK4 HSPD1 CCL2 MYD88 UBE2V1 IFNG NFRKB COX2 PGLYRP1 CSF2 CASP8 IRF7 HEL-S-71 CXCL10 IRF3 TNF TNFRSF1A NR2C2 MAP3K14 TNFAIP3 MUC13 CHUK TRADD MAP2K4 CSF3 TICAM2 IL1R1 LY96 RIPK2 TICAM1 BTK JUN HMGB1 CD14 IFNB1 PELI1 MAP3K7IP1 NR1C1 IKBKB NFKBIA NFKBIB LTA NFKB1 RELA CD80 MAPK8IP3 FADD TIRAP PMC9031072__F2 Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use EPOR EPO PMC2838200__F3 Proposed scheme for how macrophage-based nanoparticle drug delivery could affect disease outcomes in neurodegenerative disorders NGF GDNF BDNF PMC4452916__F3 The effects of hrHPV on NFKB signaling TLR5 HDAC3 IFRD1 TLR9 TRADD EGFR RELB TRAF3 TRAF6 TLR1 HDAC1 TLR3 RIPK1 TLR7 TLR4 TRAF5 RELA SHARPIN CD40 HEL-117 TRAF2 FADD MAVS PMC9214686__F2 Signalling pathways downstream of cGAS and of endosomal TLRs TBK1 TLR8 CGAS TLR7 TLR9 IRF7 IRF3 IRAK4 MYD88 TLR3 PMC4762514__F4 Metabolic pathway alterations in PCT HEL-S-182mP NAMPT NAGK PGM3 CHDH AASDH AASS TMLHE MTR ALDH7A1 OGT GNPNAT1 HK2 PNP PMC6011013__F5 Integration of mRNA data and CNAs profiles: BMD+DAD-screening network using Coxnet (top) and ADMMnet (bottom) methods with mRNA expression data and the integration of mRNA data and CNAs profiles OR8S1 IFNA6 OR10AD1 IFNK GLRA1 FGFR4 OR6Y1 GLP1R OR5I1 PMC6011013__F4 mRNA expression data: BMD+DAD-screening network using Coxnet (left) and ADMMnet (right) methods with mRNA expression data and the integration of mRNA data and CNAs profiles OR2B11 RRM2 ERBB2 BCL2 MYL12B OR1C1 TACR1 FGFR4 ALDH3B2 PKMYT1 GLP1R OR5I1 PMC3558460__F1 Signal activation of human somatostatin receptor subtype-2 by membrane-displayed somatostatin SSTR2 HEL-S-5 PMC4856717__F1 Main pathways involved in CD40-TRAF signaling CD40 CD80 CCL2 TNF PMC3009535__F3 Functional module of the CXC chemokine pathway uniquely identified by NeMo GNA11 PRKCA PLA2G2E PLA2G6 PLA2G3 GNA13 PLA2G5 PLA2G2D PLA2G2F PLA2G2A PLA2G10 PMC8124173__F3 Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update MFN2 APAF1 MDM2 BCL2 BDNF BAX PMC6462412__F2 DNA repair pathways—a toolkit for viral replication PALB2 GEN1 FANCD2 BLM BRCA2 SLX4 EME1 RAD51 ATR DNA2 BRCA1 PMC2660752__F6 Metabolic origin of glyoxylate in M HEL-S-62p PMC5440111__F2 Enhanced anabolic PI3K/Akt pathway in a cancer cell BAD MYC ACLY MTOR PMC4912847__F1 Exosomes in liver pathology CD63 CD82 DROSHA CD81 PMC3294420__F3 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links ELF2 PNPLA3 CS DGAT2 EBP IL6 LPA XBP1 IRS1 FOXO1 G0S2 TLR4 CD2 STAT3 CD36 PMC3294420__F2 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links TLR4 CS LPL LPA IRS1 CD36 PMC8301965__F9 Hair Growth Stimulation Effect of Centipeda minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways IGF1 APC LRP5 LRP6 PMC11937447__F2 Functions and mechanisms of lncRNAs in endoderm differentiation CTCF GATA6 HOXA1 GSC SOX17 EN2 EN1 IGF2BP2 FZD5 FOXA2 PMC10865172__F3 Roles and mechanisms of ESM1 in tumor angiogenesis EGF DLL4 EGFR ESM1 VWF MTOR MAP3K7IP1 STAT3 TAB3 PMC4467862__F3 Crosstalk between erythropoiesis and iron metabolism involving TGFB family member GDF11 ERFE BMP6 SMAD4 GDF11 PMC4247524__F2 Long-patch BER pathway FEN1 LIG1 PCNA PMC4711368__F4 Signaling pathways of cytokines in GnRH neurons CNTF LIF IL1B PMC4247524__F1 Short-patch BER pathway PNKP PMC9214686__F4 Transport and metabolism of cGAMP CD14 CGAS ENPP1 SLC46A2 PMC3737373__F9 RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma TIAM1 EGF MAP1B CD44 PMC3258560__F1 Signal transduction by TGFB family members SMAD2 SMAD6 RHO SMAD1 DKFZp781O1323 PMC8246814__F2 Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation CIC CD36 PMC11121563__F1 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review CEMIP PIK3AP1 CYLD HDAC7 PTEN CCL18 MTOR COL1A1 CCL22 BDNF PMC3303613__F1 Signaling pathways in the pathogenesis of nasopharyngeal carcinoma (NPC) FOS APC EGFR MYC CDK4 PTEN TERT PMC9554952__F4 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer TSC2 TSC1 EGFR PTEN RHEB STAT3 PMC11121563__F3 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review PTEN MTOR PMC5776718__F1 Overview of the L-lysine biosynthetic pathway in Synechococcus sp CIT MAL PMC9554952__F3 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer TRADD MCL1 TNF FADD BAX PMC11121563__F2 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review FOXO3A PTEN EMP1 PMC3159580__F3 Not(ch) just development: Notch signalling in the adult brain NUMB RBPJ DNER SOX2 EGFL7 HIF1A MTOR CDK2 F3 SHH CCND1 BDNF STAT3 PMC1884140__F11 Schematic representation of the differentially expressed genes and how they are induced upon injection by (A) pristane or (B) phytol IFIT3 OASL OAS1 MMP12 IRF7 MX2 IFNG PMC11121563__F4 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review HEL-S-94n BCL9 PMC5723907__F1 General induction and receptor signaling pathways of type I and type III IFNs STAT1 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 IRF-1 MAVS PMC4141691__F5 Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease RICTOR RPS6KB2 GHR PTEN MTOR EIF4B PMC5376156__F1 Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/Beta-catenin Signaling Pathway CCND1 SOX9 PMC6136541__F4 E2 on bovine mammary epithelial cells during Staphylococcus aureus infection IL16 IL1B S100A7 PMC3775402__F1 Alternative splicing regulation of the Ras-MAPK pathway EIF4E PMC5397778__F3 Helicobacter pylori-induced chronic inflammatory and neoplastic diseases CDX2 MSC SHH IFNG PMC5397778__F2 Simplified schematic depiction of the canonical hedgehog (HH) signal transduction pathway within the primary cilium HHIP BOC SUFU GPR161 GLI3 GSK3B SMO GAS1 PMC7154114__F5 Systems biology is an interdisciplinary field that involves computational and mathematical investigations for modeling a complex biological mechanism PLK1 FOXM1 FOS EGFR VHL FUT1 IL6 CDKN1C FOXD1 NMU MDM2 CCND1 GTSE1 PMC3775402__F2 Alternative splicing regulation of the PI3K-mTOR pathway TSC2 PTEN EIF4E MTOR RHEB PMC3759017__F1 Key mutational and therapeutic targets in melanoma ME1 KIT BRAF NRAS PTEN AKT3 PMC4918247__F1 HGF/c-Met signaling cascades.Notes: Upon binding of HGF to its receptor c-Met, c-Met is dimerized and activated by phosphorylation of Tyr 1234 and Tyr 1235 residues HGF GRB2 RAC1 RAF1 MTOR CDC42 STAT3 PMC6163197__F2 Main metabolic pathways triggered by chronic brain hypoperfusion (CBH) TSC2 ATM BCL2 BNIP3 MTOR TG RHEB PMC7880438__F8 PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation TBK1 RNF5 IRF3 MAVS NBR1 PMC6936254__F2 PPI network of DEGs PMEL APLN JAG2 NOX4 EEF1A2 KCNK3 CACNA1A TUBB2A MCAM KDR JUP ANGPT4 LIPG DISP2 CD177 GIMAP4 TXLNB DHRS3 CSF2 MDK FAM131B FGA MMP10 RELN GPR17 ENAM PTGIS TFPI IL20RB CD34 CHAC1 MMRN1 HLA-B ASAH2 PDE4B ASNS KCND1 CYP2U1 PLA2G4C SMAD1 GSDMB NCF2 NTNG2 PMC9653480__F6 Obesity downregulates lipid metabolism genes in first trimester placenta LPL TG NR1C1 ACOX1 PMC6198802__F3 Key cellular and molecular pathways regulating blood-brain barrier integrity ANGPT1 PTCH1 TGFBR2 VEGFA SHH SMAD4 EPHB2 PMC6707807__F1 Enriched immunological pathway and genes AGAP1 HLA-E HLA-G EHD3 SHC3 FGFR2 HLA-B HLA-C HLA-F NCR2 FYN WASL MRC2 TNFSF10 ZAP70 PMC8326125__F8 TNFA augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell CXCR3 CXCL10 ARHA PMC8201612__F4 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand HEL-S-62p TSC2 TSC1 PPM1K MTOR RHEB MLST8 PMC6027909__F1 Primary mechanisms by which AIBP protects against macrophage inflammatory response MYD88 ABCA1 IL1B STAT3 PMC8201612__F3 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand ELF2 TSC2 TSC1 F2 EIF4E MTOR DEPTOR RHEB PMC8201612__F2 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand ELF2 TSC2 RICTOR TSC1 IGF1 GSK3B MTOR DEPTOR IRS1 RHEB MLST8 PMC2394714__F10 TGFB1-induced PAI-1 expression in VSMC SMAD2 EGFR SMAD4 ARHA PMC5487013__F7 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells BAMBI NOTUM SOST LRP5 CER1 LRP6 PMC6611711__F1 Lipid biosynthesis in cancer cells SLC25A11 SCD ACSS2 ACLY MTOR TG PMC3978476__F4 Major metabolites and genes contributing to the choline metabolism pathway GDPD5 PLA2G2E CHKA PNPLA6 PLA2G6 PNPLA7 CHKB PLCD3 PLD3 SLC22A2 PLA2G10 PMC5352242__F1 Schematic illustration of the intracellular trafficking dynamics of mitochondria-targeting nanoparticles PINK1 TBC1D15 FIS1 PMC3560328__F2 DNA interstrand crosslink repair and cancer FANCD2 BLM RMI2 RMI1 BRCA1 FAN1 BRCA2 FANCM FANCL FANCA ATR FANCB FANCE FANCG FANCF PMC9555684__F1 Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast ERG IPP HEL-S-5 PMC3560328__F4 DNA interstrand crosslink repair and cancer FAN1 EME1 PMC9629834__SF4_2 Protein network and Netrin-DCC pathway analysis PLCG1 AP2A1 AP2A2 SYNGAP1 NCK1 NTN1 AP2M1 PTPN11 SRC DCC ROCK2 CAMK2D STXBP1 CDK15 PURA TSPAN7 CAMK2G ARHA RAC1 SNAP25 NFATC2 PRKCB AP2S1 CDKL5 GNAO1 CAMK2A CDC42 PMC3560328__F3 DNA interstrand crosslink repair and cancer REV1 FAN1 FANCD2 BLM BRCA2 EME1 RAD51 FANCM ERCC1 BRCA1 RAD51C PMC5293538__F1 Abbreviated polyamine synthesis pathway SRM SMS AGMAT PMC2630373__F1 Regulation of G1/S transition by growth factor (insulin and IGF-I) signaling in Beta-cells PDX1 FOXM1 SMAD2 MDM2 SMAD4 CCND1 IRS1 CCND2 PMC4380073__F2 Simplistic overview of the top two mutation-enriched transduction signaling pathways in ATC as according to the Genomatix Pathway System IGF1R BRAF NF2 MAPK10 PIK3CA RAC1 RAF1 HRAS MTOR PMC8460515__F2 Pharmacological properties of baicalin on liver diseases: a narrative review NLRP3 SAMD3 GCLM GCLC SIRT1 BAX NR2A2 PMC8615556__F1 miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma STAT1 IGF1R IGF1 ATF3 IFNGR2 CCL4 PTEN JAK1 B2M IFNGR1 USP22 PMC7706582__F4 Epigenetic Mechanisms in Leukemias and Lymphomas MYC TRAF3 MYD88 RB1 CDKN2A MAF SMARCA4 BCL10 BCR PREB PAX5 TNFSF14 LPL NOTCH1 EZH2 B2M NOTCH2 GNA13 KMT2C TNLG8A BCL2 KLF2 TNFAIP3 MLL2 NFKBIE HEL-S-62p TBL1XR1 BRAF CD83 PTEN CCND3 IKZF1 ATM PTPN11 CCND1 IRF4 SGK1 MEF2B FGFR3 ARHA CHD2 CD79B CD79A ID3 BCL6 BIRC2 CARD11 NFKBIA CREBBP FLT3 TRAF2 STAT3 PMC7730528__F10 Graphical illustration of prolidase-dependent EGFR, B1-integrin receptor, TGFB1, and IGF-1R-downstream signaling IGF1R SOST EGFR GRB2 SHE SRC MTOR PMC7412373__F4 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways PTEN MYD88 MTOR PMC7412373__F3 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways NLK DUSP5 E2F5 PTEN MTOR DKFZp686F0183 PTPN22 CD69 PMC4352617__F3 Proposed mechanism for transcription-dependent p73-induced apoptosis CASP3 GRAMD4 FADD BAX PMC6611711__F6 Phospholipid and TG synthesis pathway PC PGP LPA TG SMS FASN PEMT PMC11013731__F6 Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NFKB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice TLR4 UNK PMC5487013__F8 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells GPC4 NR5A2 CAMK2D ETV4 MYC SNAI2 CER1 FZD4 DKK1 SOX17 WIF1 FZD5 CXXC4 DKK4 WNT3 LEF1 NFATC2 TFAP2A GATA3 PMC7412373__F1 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways MAF TLR4 EBP APC PTEN SOX6 PMC7254050__F5 Proteins co-associated with hyaluronidase (HYAL)-2 have roles in actin organization and contraction function ACTRT1 POTEF HYAL2 ARHA HEL114 ACTG1 PMC5573869__F3 Regulation of the G1/S cell cycle checkpoint pathway by Pontin/Reptin at multiple levels ECD CDK2 GSK3B MYC CCND1 CDK4 CDK6 PMC7461995__F1 Pseudomonas aeruginosa Can Degrade Interferon λ, Thereby Repressing the Antiviral Response of Bronchial Epithelial Cells OAS1 STAT2 IRF7 IRF9 IRF3 TYK2 JAK1 IRF-1 MX1 PMC7465013__F5 Gene networks analysis of quercetin–resveratrol modulated genes suggest IGF1 and BCL2 as key signaling nodes associated with anti-PCa effects AIP TUBB IGFBP7 MSX1 CAV2 TMPRSS2 PMC5573869__F6 Regulation of DNA damage response and repair by Pontin/Reptin INO80 FANCD2 ATM YY1 ATR BRCA1 PMC5573869__F5 Regulation of transcription factors by Pontin/Reptin HINT1 RPAP3 APPL2 MYC CCND1 HEL-S-116 HIF1A ETS2 IL1B TERT APPL1 PMC8509131__F1 NLRP3 Inflammasome: Relevance in Solid Organ Transplantation NLRP3 HMGB1 SYK IRF3 TXNIP TNF FADD PMC5573869__F7 Role of Pontin/Reptin in the EMT pathway EGF VTN ZEB2 EGFR CDH2 HIF1A MTOR STAT3 PMC6299112__F4 Proposed roles for miR-137 at the glutamatergic synapse CPLX1 RICTOR MIB1 GSK3B NRG1 PTEN MTOR BDNF SYT1 PMC6299112__F3 Neuronal signaling events that influence miRNA biogenesis, activity, and degradation AGO2 DROSHA MOV10 BDNF PMC6299112__F2 Overview of the canonical miRNA pathway, from synthesis to degradation DGCR8 DROSHA MOV10 PMC9134343__F3 Controversial Role of IL-33 in Lung Cancer IL33 MYD88 FOXP3 PMC11599537__F3 TLN1 in cancers F2 F3 CDK5 TLN1 PMC8748693__F3 Metabolic routes contributing to ferroptosis GPX4 STEAP3 FACL4 SLC7A11 SFXN1 SLC3A2 DHODH IPP PMC10854112__F10 Schematic showing the preliminary mechanism of Gnao1 in SCs regulating SC differentiation and myelination EGR2 PRKAA2 OLIG1 POU3F2 GNAO1 POU3F1 PMC8630058__F5 Metabolic pathway linking methane oxidation to selenate reduction by bacterial consortia CS MMD HBD GCK AGXT PMC6579773__F2 Alternative pathway of the complement system HEL-S-62p C6 PMC7284929__F7 Ingenuity Pathway Analysis (IPA) and western blotting validation of common differentially expressed proteins PXDN SAA1 SLC4A4 FGL1 ABCB6 ZNF183 UQCRC1 ACACB NDUFA13 LETM1 MPC2 SERPINA1 GPD2 UQCRHL CA4 ETFA PGAM2 OPA1 ETFB SCARB1 RMND1 PON1 EVL AFM IDH3B GPLD1 NDUFC2 HEL-S-162eP HEL111 EHHADH AK1 ACADM TGFBI CD36 PMC6923491__F2 Bayesian theorem-optimized possible optimal acting pathway of axonal regeneration NGF FRS2 PIR GSK3B GRB2 ARHA BDNF CRK OCA2 PMC6923491__F1 Pathway diagram of axon regeneration regulatory network NGF FRS2 GSK3B GRB2 ARHA BDNF CRK OCA2 PMC6185869__F1 Simplified PI3K Signaling Cascade and Known Clinical Disorders Caused by Genetic Pathway Activation BAD PTEN AKT3 PMC8036978__F1 Simplified extrinsic signaling pathway from TNF-R1, Fas, DR4, and DR5 TRADD TRAF2 FADD PMC7730007__F8 Mapping the S1P-S1PR1signaling pathway in differentiated SGBS and 3T3-L1 adipocytes PLCB2 MAPK4 SMPD2 MAPK7 SPHK2 PLCB1 AKT3 PMC4342569__F8 The multi-targeted tyrosine kinase inhibitor vandetanib plays a bifunctional role in non-small cell lung cancer cells RET UNK RHO PMC4484476__F7 Inhibition of Beta-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear Beta-Catenin/TCF-1 complex: Critical role of STAT-3 APC GSK3B STAT3 PMC2718747__F10 A model of EGF/EGFR-induced inhibition of a Luminal-A phenotype in MCF-7 cells EGF EGFR GATA3 PMC7513516__F1 Domain structure and signaling pathway of STAT3 ME2 MMP2 TWIST1 CXCL10 MYC SRC CD80 MCL1 TNF HIF1A SOCS1 STAT3 PMC7713510__F6 SRC-1 and SRC-2 serve critical roles in developmental regulation of 11Beta-HSD1 expression by glucocorticoids and cytokines GC TNF IL1B PMC138687__F1 The TGFB signaling pathway, showing the activation cascade and points of inhibition (??) BAMBI EGF SMAD6 PMC149906__F5 A model to explain the effects of varying Fgf8 dosage on cell survival EMX2 FGF8 FOXG1 SPRY1 BMP4 PMC3899875__F4 MiR-148b in the mTOR signalling pathway TSC2 RICTOR TSC1 BRAF PTEN EIF4E HIF1A MTOR EIF4B IRS1 RHEB PMC3899875__F5 MiR-15a in the AD pathway CASP3 SNCA CASP12 BAD GSK3B LPL CASP9 APP TNF CASP8 FADD APOE PMC9546099__F5 Absorption, metabolism and excretion of opicapone in human healthy volunteers CTGF PMC8843878__F3 Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways EGF NR3A2 PGR FOS ACACA EGFR GSK3B VEGFA MYC PTGER3 NPEPPS ACHE TNF POR HEL-S-130P PSMD3 MMP3 PRKCA AHR CYP3A4 RELA PPARG SELE PMC3517193__F1 Graphic illustration of the perturbation of the insulin signal transduction pathways by cellular stressors BAD IRS4 GRB2 PTEN MTOR ELF4 IRS1 CBL PMC6386093__F5 Metabolic profiling of intracellular metabolites involved in branched-chain amino acid catabolism HEL-S-62p ACADS PTEN PMC3821079__F1 Schematic representation and overview of PI3K/AKT/mTOR/PTEN signaling TSC2 TSC1 PTEN MTOR PMC8368180__F1 Inflammation and the TME in oesophageal carcinogenesis IL10 IL6 IL1B IFNG PMC11648920__F3 Schematic diagram represents the DEGs expression enriched in SA, JA and ET signalling pathway EBF2 PMC3821079__F3 Several inhibitors linked to the PI3K/AKT/mTOR/PTEN signaling pathway are shown TSC2 TSC1 PTEN MTOR PMC11648920__F5 Various signalling pathways and resistance mechanisms in wheat in response to Puccinia infection ERF TF CBL PMC9235346__F3 Integrating proteomic and clinical data to discriminate major psychiatric disorders: Applications for major depressive disorder, bipolar disorder, and schizophrenia TH TFPI CFB CTSS SERPIND1 MBL2 NPC2 TF CP GPR37 PMC4091179__F10 Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells TIA1 MTOR FKBP1A PMC4428629__F1 Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism KIT MOB2 GCK ACE2 PMC4465887__F1 Advances in recent patent and clinical trial drug development for Alzheimer’s disease APP ACHE PMC3773820__F8 Role of Nor-1 in incretin-induced insulin expression and secretion and hypothetical localization of the TCF7L2 and NR4A3 SNP effects NR4A3 INS TCF7L2 PMC7385902__F3 Correlation plots for genes (absolute Pearson correlation > 0.4) that contributed to the enrichment of MAPK38 pathway in ER negative tumor and phosphocholine synthesis in ER negative normal-adjacent samples LPIN3 MAPKAPK2 CHKA ATF2 HMGN1 CHKB MEF2C PMC6457711__F2 Regulatory mechanism of calcium on HIF1A induction TRPC1 TRPC6 MCU TRPM2 MTOR STIM1 TRPM8 PMC11591698__F1 General Hippo signaling pathway TEAD3 PATJ AMOT NF2 CD44 TEAD4 SCRIB LATS1 RHO LPA LATS2 TEAD2 PMC6773241__F8 Graphical abstract showing the main findings of this study E2F4 EGFR RAF1 HRAS PMC11591698__F2 IPA ingenuity pathway analysis: IPA is a software application used for the analysis and interpretation of YAP’s complex biological interactions in cancer development SCRIB FAT4 CRB1 PMC11591698__F4 Hippo pathway NF2 SCRIB TF PMC9181096__F11 Ginsenoside Rc Promotes Bone Formation in Ovariectomy-Induced Osteoporosis In Vivo and Osteogenic Differentiation In Vitro RUNX2 APC GSK3B PMC9224458__F2 MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition SMAD2 APC TGFBR1 PMC5661129__F2 Crosstalk between cancer and cancer stem cell-related pathways COBL EGF FOXD3 EGFR PROC PMC4914454__F5 “The Expanding GRK Interactome: Implications in Cardiovascular Disease and Potential for Therapeutic Development” CA3 HDAC5 PMC4717619__F1 Schematic of tumor cell interactions in the brain CXCR4 EGFR JAG2 NOTCH1 IL6 PTEN CXCL12 ROR1 PMC11705629__F5 AMPK signaling pathway in macrophages and fibroblasts cross-talk TSC2 SMAD2 SMURF2 SMAD4 CCL2 MTOR CSF1 PMC5241746__F10 Working model ERBB4 EGFR NOTCH1 PMC6033069__F4 The anti-inflammatory effects of MPQP on the LPS-induced inflammatory pathway TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC8268872__F1 Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling GRB2 MTOR IRS1 PMC6430496__F2 Underlying molecular mechanisms of ZFAS1 in multiple human cancers AGO2 MMP14 KLF2 MMP16 EZH2 NKD2 PMC11350703__F18 PDK1-mediated TGFB/Smad signaling pathway by hypoxia in yellow cattle and yak PASMCs SMAD2 SPHK1 PMC8306115__F3 Ciliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis IHH CS FLNA CEP57 MCPH1 RAB23 IFT140 TMEM216 CDC45 IFT43 WDR35 GLI3 EVC SMO NEK1 PMC8908322__F1 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? EGFR TF PMC10816037__F1 Different signaling pathways affected by the probiotic strains with anti-obesity or anti-diabetic properties in C NR1C1 ACOX1 PMC7563518__F1 Metabolic pathways of l-tryptophan (a) and l-arginine (b) IDO1 IDO2 NOS2 SMS TDO2 ASL PMC6764206__F4 Biosynthetic pathway of plasmalogens and diacyl phospholipids PC CEPT1 PGP CDS2 PCYT2 PISD C1S PEMT PMC5439240__F2 Paracellular intestinal barrier in health and inflammation HEL-S-79 CLDN5 CLDN2 PMC6070911__F1 Biosynthetic pathway of ansamitocin P-3 GAL ACD PMC5963017__F8 Pridopidine enhances cAMP/PKA and TrkB pathway genes in the YAC128 striatum HEL70 FOS RGS21 BDNF GPR31 DUSP11 PMC9306014__F1 CDK4 stabilization and canonical function in the cell cycle MYC VHL CDK4 CDC37 PMC11274597__F1 Outline of the HH signaling pathway [16] KIF7 SUFU SMO PMC4440459__F16 Summary of Ingenuity Pathway Analysis (IPA) STAT1 S100P TPM1 DPP4 LILRB3 SMC2 DAP ALDH18A1 FLNB CNN2 SMC4 AK1 PMC8908322__F3 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? EGF BTC ATG12 NGFR GC EGFR NRG1 PICALM HSF1 GATA2 PMC8908322__F2 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? EGFR SOX9 PMC3588201__F1 Gene regulatory networks for cDC and pDC development BATF3 PDC GIG8 RELB GFI1 FLT3 IRF4 STAT3 BATF PMC6306406__F1 Schematic elucidation of IL-33 IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC7419519__F3 KEGG pathway mapping of CHO global spectral library OS9 E2F4 PLK1 SMAD2 GSK3B SMAD4 WFS1 DBF4 ORC3 ORC2 CDK7 CDK6 ATM ATF4 EIF2A MDM2 CDK4 CDC2 UFD1L BAX CASP12 ORC6 APC SVIP RBX1 STAG1 SEC63 CDC45 STAG2 CDC20 CDC6 SMC3 CDK2 BCL2 ORC1L ATR PCNA SKP2 SEC62 MYT1 PMC10177097__F9 Effects induced by Exe plus CBD in MCF-7aro cells TFF1 AREG PMC6126011__F2 Leptin intracellular signaling pathway TSC2 POMC TSC1 SOCS3 GRB2 IRS1 STAT3 PMC3442876__F2 Autophagy in immunity HMGB1 CALCOCO2 SQSTM1 IRGM IL1B NBR1 PMC4571863__F11 Model showing that KLF17 suppresses cancer metastasis via a p53-dependent pathway (a) and showing that a novel positive feedback loop exists between p53 and KLF17 (b) HEL113 KLF17 PMC3234240__F2 Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays COX7A1 SNCA ACTG2 CISD1 PDK2 CREB1 COXFA4 TNF IL5 MYH6 PDK3 NDUFB10 APP CKMT2 PMC4001935__F7 FoxD3 regulates cranial neural crest EMT via downregulation of Tetraspanin18 independent of its functions during neural crest formation TSPAN18 FOXD3 SOX10 PMC8375236__F3 ATM at the crossroads of reactive oxygen species and autophagy TSC2 PEX5 ATM ADH5 MTOR PMC8375236__F2 ATM at the crossroads of reactive oxygen species and autophagy PEX5 ATM ADH5 PMC5738336__F9 KEGG (Kanehisa & Goto, 2000) PI3K-Akt signaling pathway (map04151) is enriched for genes differentially expressed between lesion and healthy lung tissue in cattle challenged with BRDC pathogens ME1 BAD EBP PTEN RAC1 MTOR RXRA TSC2 BCR MDM2 SYK EIF4B RBL2 CD19 PMC6312990__F4 Signalling pathways related to PRL-3/EGFR/c-myc genes in cancer cells CSK EGFR SRC PTEN PMC11674862__F4 ADAM17 activation triggers AREG-dependent pathways STAT1 AREG EGFR ADAM17 PMC6209233__F8 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential TH MAL PMC8181544__F2 Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications? HEL-S-62p ACE2 PMC11674862__F2 Interactions of ADAM17 with IL-6, IL-1B, and IL-15 IL15RA IL1B ADAM17 PMC4703318__F1 Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach HIF1A FBXW7 FAF1 PMC6209233__F9 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC8425587__F1 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) HSF1 TCF4 PMC8425587__F4 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) SQSTM1 KLF4 TRAF6 TNF PMC8425587__F6 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) EGF EGFR VHL TRAF6 HIF1A NBR1 PMC8425587__F5 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) KEAP1 SQSTM1 TRAF6 ECSIT TNF MTOR PMC9345804__F1 Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP CD5 EGFR CD44 POLL MTOR PMC3494151__F4 Impact of SIRT1 knockout on selected cellular pathways and protein complexes ING3 PUF60 PRPF38B SF3A1 ING4 KAT7 PRPF31 CHERP ZMAT2 SNRPA1 PRPF4 SNRNP200 RBM17 RUVBL1 EP400 PRPF40A LIG1 SNRPC RBM25 EPC1 HNRPA3 TCERG1 SNRPD2 DDX42 DMAP1 U2AF2 CDK9 SIRT1 PCNA BRD4 PRPF3 TRRAP VPS72 DHX15 SNRPA YEATS4 FEN1 ING5 PCBP1 SMNDC1 SF3B2 DDX5 PRPF8 RUVBL2 MEAF6 DKFZp434N041 NCBP1 SNRPD3 PHF5A PARP1 HDAC1 PRPF6 TRA2B RBMX PMC5801050__F3 Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation SPOP PMC10937391__F9 Hypotheses on the mechanistical/functional involvement of each microRNA and its potential mRNA targets on OPC differentiation MBP ARHA PTEN RAC1 RRAS2 RHEB RAB10 PAK1 FYN CCND1 MYRF BNIP3 JUN ELMO1 PMC9162454__F2 Pyroptosis is executed by the gasdermin pore-forming family of proteins GSDMA TNF GSDMC AIM2 GSDMB GSDMD BAX DFNA5 PMC3874794__F2 An outline of the GPI and GPI-anchored protein biosynthetic pathway PIGU PIGM HEL-S-5 PMC4601220__F1 RNAi pathways in insects AGO1 AGO2 DROSHA RAN PMC3018616__F1 TGFB superfamily signaling pathway PLG SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC4539294__F2 Schematic of the itch spinal cord circuit.The initial stages of the itch-circuit in the spinal cord are characterized by the expression of neuropeptides and the post-synaptic expression of their cognate receptors SST NPPB ITCH PMC4743801__F3 The globo-series pathway in human FUT1 hCG_1998026 B3GALT5 PMC9367932__F1 Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions CCR2 CD207 CCR6 CCL20 CCL2 TNF PMC8911152__F2 New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females TSHR TRH FSHR TRHR NR1A2 STAT3 BAX PMC8549629__F8 Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro TIAM1 BTK PAK1 SYK RAC1 TRIO PMC9475358__F2 Tumor and Metastasis Initiation by Chemokine Receptors CXCR4 SMO CXCL12 PMC11611719__F7 Schematic model indicates that ozone promotes macrophage efferocytosis and alleviates neuropathic pain SOCS3 MERTK ADAM17 PMC8023146__F1 African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway TBK1 CGAS ULK1 IRF3 PMC4963810__F1A Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer APC GSK3B LRP5 LRP6 PMC9330518__SF1 Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy SIRPA CD47 PMC9139855__F2 Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications PLAT AHR CYP1A1 IL6 CYP1A2 PMC8688453__F1 Mitophagy process PINK1 FUNDC1 BNIP3L PHB2 PMC8134040__F7 EphA2–YES1–ANXA2 pathway in GC growth and progression ANXA2 MYC YES1 EPHA2 STAT3 PMC6712457__F3 Linc00152 promotes the proliferation of gastric cancer cells by regulating the PI3K/AKT signaling pathway EGF BAD PDK2 EGFR PTEN MTOR PMC6600655__F1 Agent that activates the cascade in the MAPK pathway, which can lead to TJs opening or assembly MMP7 EGF HGF PMC9688352__F1 Macrophages and Wnts in Tissue Injury and Repair APC GSK3B LRP5 LRP6 ARHA RYK ROR2 JUN PMC6712457__F1 Linc00152 promotes the proliferation of HCC cells by activating the mTOR signaling pathway EGF BAD PDK2 EGFR PTEN MTOR PMC5793041__F6 Integrative view of DENV-induced metabolic alterations in hepatic cells TG FASN HEL-S-5 PMC2963103__F1 Normal biology of the VHL-HIF axis in the setting of (A) normoxia and (B) hypoxia MAPKAPK2 EPO EGFR VHL MAPKAPK3 BNIP3 MTOR TGFA PMC3299304__F3 Molecular mechanisms of HGF-c-Met-mediated signaling for inhibiting TLR4-mediated NFKB activation in macrophages TLR4 HGF GSK3B PMC6538558__F3 Three example models in the CODA-ML format UBC FGFR1 CDK2 EGFR GSK3B MYC CASP9 CDK4 PMC7479313__F15 Signaling Pathways of E2Fs in Gastric Cancer (TGFB Signaling Pathway) RARA HGF CDX2 ERBB2 POLK APC SHH BCL2 ATR MUC2 TERT PMC7012489__F1 Canonical and non-canonical nuclear factor kappaB pathways BIRC3 BCL2 CD40 PMC5518632__F3 NLRC5/CITA: a key player in cancer immune surveillance HLA-A PMC4418510__F1 Canonical TNFR to Nf-kB pathway RIPK1 TRADD CYLD TRAF6 TRAF2 PMC7072652__F2 Failure of major homeostatic mechanisms contributes to senescence onset MDM2 APP MTOR SIRT1 PMC12236747__F3 Indole metabolites induce neuroinflammation through the AHR and NTS pathways SOCS2 FLT1 AHR NTS IFNAR1 BDNF VEGFB TGFA PMC5735681__F1 Different proteins on the Wnt signaling pathway WNT3A APC WNT7A GSK3B PMC4334449__F1 Pathogenesis of HCC and targets for chemopreventive agents COX2 CDK2 EGFR MYC MDM2 PTEN MTOR PMC4618041__F7 Model depicting Dcp1-mediated translational repression in endotoxin-tolerant cells AGO2 TLR4 RBM4 PMC5735681__F3 Interaction between the Wnt and the Notch signaling pathways HES5 WNT3A HES1 PMC7468867__F9 The regulatory effects of foxtail millet on the progression of colitis-associated colorectal cancer (CRC) AHR PCNA STAT3 FOXP3 PMC5285348__F8 Mutual regulation between miRNAs and the Wnt pathway determine the survival of Mycobacterium tuberculosis (M FOXO3A APC FZD4 DKK1 MYD88 TNF PMC5285348__F7 Nucleotide-binding oligomerization domain 2 (NOD2) and the activation of the Wnt pathway in response to Mycobacterium tuberculosis infection LEF1 IL16 APC LYPD6 NOD2 PMC5313500__F2 The proposed cellular functions of cellular NLRC5 NLRP3 MMP7 USP14 SMAD2 SMAD4 TRAF6 CSA2 TRAF2 IL1B MAVS PMC5285348__F9 Beijing Mycobacterium tuberculosis (M LEF1 APC NOTUM SOST CER1 ARHA PMC7834968__F8 Schematic diagram showing how ASV alleviates silica-induced pulmonary fibrosis by regulating TGFB1/Smads pathway SMAD2 SMAD4 PMC3368918__F1 Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis CYP27A1 NR1i1 CYP2R1 DHCR7 GC CYP24A1 CYP27B1 PMC7201093__F1 Summary of the mechanisms that myocardial protection mediated by melatonin through receptor and non-receptor pathways MFN2 BAD GSK3B NOTCH1 MCL1 RORA BDNF RYR2 SIRT1 BAX SIRT3 PMC5285348__F3 Canonical Wnt signaling pathway LEF1 APC PMC5285348__F5 Mycobacterium tuberculosis (M WNT3 TLR4 MYD88 TNF FZD1 PMC7824104__F2 Nrf2 signaling MAF AHR KEAP1 SKP1 RBX1 PMC8656547__F2 Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma SMAD2 ATF2 SMAD4 TESC TUG1 MAP3K7IP1 PMC6436804__F9 Summary of the toxic mechanisms of ZEA on breast cancer cell growth with antagonistic effects posted by AFB1 SET PGR MAPK3 SRC PMC10378139__F2 Ferroptosis in Cancer Progression EREG EGF COX2 ACSL3 PMC5061598__F2 Proposed model for how the activation of ECM receptor pathway in the adipose tissue is linked to obesity-associated insulin resistance ATM CD44 VEGFA XBP1 CD36 PMC2835492__F4 Regulation of MUC4 expression MUC4 SKI IFNG PMC4960920__F1 Schema of upstream and downstream signaling pathways of mTORC1 TSC2 TSC1 GSK3B EIF4E RHEB PMC3336023__F3 Chronic alcohol exposure alters gene expression in HepG2 cells FGA HRG TRADD F8 HEL-S-92n MTOR AMBP OSMR PELO HEL111 F2 CRP AHSG VWF APOH EN1 TRAF2 CP PMC4073278__F7 The changes that are induced in cells by a deficiency of RPs ATM ADA MTOR ATR PMC5192018__F3 Pubertal development and regulation GNRHR IGF1 KISS1 PMC3336023__F4 Chronic alcohol exposure alters gene expression in HepG2 cells MAF GCLM FTH1 ATF4 FTL CRAT HEL-S-107 VCP JUN TXN CLPP PMC3209136__F2 Biosynthetic pathway for UA and flocculosin FAT2 FAT1 FAT3 PMC4621504__F3 Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma BRAF KEAP1 AMOT EGFR CTNNA3 FGFR4 PTEN LATS1 MTOR LATS2 FGFR2 NF1 ERBB4 NF2 AXIN2 NTRK2 WWC3 WWC1 MOS PDGFRA NTRK1 APC NFE2L2 NTRK3 TSC2 YWHAQ CTNND1 RAF1 FLT3 WWC2 CTNNA2 CRB1 AKT3 PMC4593065__F1 The IGF-1R signaling network and nodes of therapeutic blockade BAD IGF1R IGF1 IGF2 GRB2 ARHA MTOR IRS1 IGF2R INSR PMC6034147__F1 Wnt signaling WNT3 IGF2BP1 APC KLF4 MTOR PMC5821264__F3 Regulation of Signal Transduction by DJ-1 TSC2 TSC1 GSK3B MDM2 VHL PTEN BNIP3 RHEB PMC5821264__F2 Regulation of Signal Transduction by DJ-1 TH TSC2 TSC1 SRC HEL-S-44 RHEB PMC3295899__F2 Matricellular Protein Thrombospondin-1 Globally Regulates Cardiovascular Function and Responses to Stress via CD47 CD47 SRC PMC8491165__F1 Sphingolipid biosynthetic pathway leading to ceramide and sphingosine 1-phosphate (S1P) formation S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 SPNS2 SMS PMC3929000__F1 TRAIL signalling induces the extrinsic apoptotic pathway MSC FADD PMC5821264__F1 Regulation of Signal Transduction by DJ-1 MMP2 MMP9 GSK3B MTOR PMC9456528__F2 DNA Holliday Junction: History, Regulation and Bioactivity SLX4 EME1 RAD51 PMC7917047__F5 Possible signaling pathway of MbovP280-induced apoptosis in BoMac CASP3 HEL-S-101 CASP9 APP BAX PMC3989838__F1 Insulin effects on endothelial cells IGF1R MTOR TET1 PMC8525369__F1 Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation CCR5 WAS FANCA CYBB PMC4920139__F1 Genes represented in the 38-gene DTC panel and their biological pathway associations HSPB7 SNAI1 EPCAM KRT19 SNAI2 FGFR4 HSPB8 FOXA1 CCND1 GSC SFRP1 SMO PTCH2 PITX2 SCGB2A2 KRT7 CLDN4 GRB7 LAMB1 TWIST1 ERBB2 GLI3 PTCH1 IGFBP4 GEMIN2 PMC7872472__F1 Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses CYP3A4 UGT2B7 PMC2723760__F4 HERPUD1 Ingenuity Pathway Analysis illustrates interactions between indicated proteins XBP1 SSR2 CREB3 MTHFD2 TMBIM6 MDH2 BATF ACAT1 VAMP3 ASNS DBP ERN1 NFIL3 PMC8651476__F2 Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases TLR5 TLR7 TLR4 IRF7 IL36A IL36B IL36G IRF3 TLR1 TLR3 PMC3472623__F1 Folate metabolic pathway HEL-S-61p MTR DHFR MTRR TYMS PMC6608078__F2 PI3K/PTEN/AKT pathway dysregulation in prostate tumor cells HEL-S-89n IL6ST PTEN XBP1 PMC3733450__F2 Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene TSC2 TSC1 VHL STK11 PRKAG2 PTEN EIF4E MTOR RHEB PMC8992550__F1 Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment SSB RAD52 RAD51 BRCA1 PMC8625721__F1 NLRP3 Inflammasome in Lupus Nephritis NLRP3 TLR4 IRAK1 NFKB1 IRAK2 TRAF6 IRAK4 MYD88 PMC8375436__F7 Key Gene and Functional Pathways Identified in Unexplained Recurrent Spontaneous Abortion Using Targeted RNA Sequencing and Clinical Analysis IL10 STAT1 STAT4 IFNGR2 TYK2 JAK1 GATA3 IFNG STAT3 PMC12246121__F8 Distinct signaling pathways in the recognition of PAMPs and DAMPs by PRRs CGAS TLR5 TLR9 IRF7 ATF2 IRF3 MYD88 TLR1 RYR2 TLR3 TICAM1 GSDMD TLR8 TLR7 TLR4 AIM2 PMC5112586__F1 Histiocytic Neoplasms in the Era of Personalized Genomic Medicine MAP3K1 BRAF ALK NTRK1 GRB2 SOS1 IRS1 ARAF PMC12246121__F9 Transcriptional regulation in PRRs-mediated inflammatory response ME1 ME2 TLR4 MAPK6 MAPK3 PMC6271622__F1 Regulation of antioxidant and detoxifying genes by the NRF2-Keap1 pathway KEAP1 SFN PMC12246121__F4 Signaling pathways mediated by iPRRs and their regulation CSK CD300A TIGIT CEACAM1 PMC3302843__F10 Hypoxia Reduces Arylsulfatase B Activity and Silencing Arylsulfatase B Replicates and Mediates the Effects of Hypoxia HIF1A COL1A1 HMOX1 PMC12246121__F3 Structure of different PRRS in the cytoplasm and nucleus TBK1 CGAS MHC2TA NAIP IRF7 NLRX1 IRF3 GSDMD NLRP3 RRM1 RRM2 HNRNPA2B1 AIM2 PMC3118552__F7 Activation of the Stress Protein Response Inhibits the STAT1 Signaling Pathway and iNOS function in Alveolar Macrophages: Role of Hsp90 and Hsp70 STAT1 JAK1 PMC8750665__F10 Cherry Polyphenol Extract Ameliorated Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Suppressing Wnt/Beta-Catenin Signaling Pathway APC GSK3B CCND1 PMC3334709__F4 Tau neuroinflammatory cascade CDK5 IL6 IL1B CD68 PMC7273093__F2 COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease ACE2 PMC3697769__F2 Signaling pathways activated in cord blood-derived CD34pos hematopoietic progenitor cells (upper panel) and in erythroblasts at day 6 of differentiation (erythroblasts, lower panel) BAD SET CCNB1 SHE NOTCH1 CCND1 JAK1 MTOR DEPTOR FOXO1 CRKL PMC12246121__F2 Structure of different PRRS in the cell membrane and the extracellular TH CLEC12A IRF7 CRP HEL-S-92n CLEC4E MYD88 MBL2 CR1 PTX3 TIRAP CLEC9A PMC12246121__F1 Key discoveries in PRRs CGAS TLR4 NLRP1 INS HEL-S-92n PMC3703662__F6 Proposed model for NV-128-induced casapase-independent cell death in OCSCs MTOR BAX PMC4043860__F2 Transcriptional control of spermatogonial maintenance and differentiation RET BCL6B ID4 FGF2 GDNF LHX1 ETV5 POU5F1 FOXO1 POU3F1 PMC7746952__F1 PAR1 functions in thrombotic and inflammatory processes in the vascular endothelium APC VWF TF PMC3814888__F5 Mitochondrial activity pathway CASP3 PINK1 LRRK2 CASP9 HTRA2 PMC4685214__F1 Signaling pathways leading to gonadotropin-induced activation of MAPK3/1 in preovulatory follicles or cultured cumulus-oocyte complexes EREG NR5A2 PGR TNFAIP6 AREG PTGS2 EGFR MAPK3 MAPK14 CYP11A1 HAS2 CEBPB PTX3 SRC MAPK1 FSHR STAR PMC11019835__F1 Canonical and non-canonical function of CD55 HEL-S-62p EGF SOX2 MMP9 GSK3B MYC BRCA1 C9 MMP2 LCK C7 C6 CD55 STAT3 PMC10151533__F2 Developmental origin of tendon diversity in Drosophila melanogaster ROBO3 EGFR ROBO1 ROBO2 PMC10944957__F1 TGFB superfamily signaling pathway and the potential therapeutic targets in pancreatic cancer GREM1 SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC7712978__F2 P53-AB feedback loop revisited SIRT6 APP MTOR PMC8266896__F7 EGR1 and RXRA transcription factors link TGFB pathway and CCL2 expression in triple negative breast cancer cells EGR1 CCL2 RXRA PMC8292865__F2 Epigenetically inactivated RASSF1A as a tumor biomarker CCNA2 CDC20 MOAP1 APC BAX PMC6921210__F7 GEFT function and signalling pathway ARHA RAC1 CDC42 PMC9120431__F3 Engineering GD T Cells: Recognizing and Activating on Their Own Way PC RAE1 VAV1 ZAP70 GRB2 DAP MICA SYK PCNA BTN2A1 IFNG PMC3625500__F5 Overview on the mechanisms of glutathione induced cell death APAF1 FADD BAX PMC6985072__F6 Working hypothesis EGF FRK EGFR PMC10751671__F1 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research IGF1 VCAM1 VEGFA MTOR PMC10751671__F2 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research IGF1 IGF2 IFNG STAT3 BAX PMC7762563__F3 Ang-TIE therapeutics against diabetic retinal diseases VEGFA RHO FOXO1 PMC7762563__F2 Angiopoietin–TIE signaling pathway in the vascular endothelium RHO FOXO1 PMC8720003__F9 Study on the Mechanism of Acori Graminei Rhizoma in the Treatment of Alzheimer's Disease Based on Network Pharmacology and Molecular Docking PGR INS ACHE TNF MTOR TRPV1 INSR TSC2 CASP3 COX2 TFF1 APP CASP8 FADD PMC4220655__F2 Selective autophagy in respiratory infection and sepsis ESX1 NLRP3 TLR4 IRGM IL1B PMC4375782__F8 Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons POMC NPY AgRP STAT3 PMC5679204__F7 Matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1 CD47 NOXA1 PMC5374883__F11 Proposed pathway of TGFB2–TLR4 signaling crosstalk in the glaucomatous TM BAMBI TLR4 MYD88 PMC5136496__F1 Apoptotic pathways APAF1 BAX PMC8135047__F1 Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis INA PMC8263657__F4 Basic approaches, challenges and opportunities for the discovery of small molecule anti-tumor drugs BAD TNFRSF1A MCL1 TNFRSF10B TNFRSF10A TNF FADD BAX BOK PMC5329138__F2 Cross-Talk between the Cytoplasmic RIG-I and STING Sensing Pathways TRAF3 TRAF6 IFNAR2 IFNAR1 MAVS PMC7276545__F2 Examples of life science networks SI TF PMC4320971__F2 Sphingolipid metabolites in inflammatory disease GLTPD1 SPHK1 CERK SPHK2 PMC4320971__F1 Sphingolipid metabolites in inflammatory disease ORMDL3 CERK SMS PMC11767564__F2 Metabolic or disease regulation by LEAP-2 antagonism of GHSR1a in human organs TIMP1 MRAP2 NPY LEAP2 AgRP GCK CCL2 MTOR COL1A1 PMC4680864__F3 Proteome Analysis of Ground State Pluripotency SFN HEL-S-44 OGDH MTOR PFKP HK2 HEL-S-281 PMC7924645__F2 MSH biosynthesis and regulation in actinomycetes MTR INS PMC5069291__F1 Schematic model of the Wnt/beta-catenin pathway APC GSK3B LRP5 LRP6 PMC5069291__F2 Schematic model of the Wnt/beta-catenin pathway in Alzheimer disease APC GSK3B LRP5 LRP6 NR1C1 PMC8063228__F6 Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development BAD PHLPP2 COX1 PTEN PCNA PMC4125356__F7 MicroRNA miR-150 modulates the expression of GAB1 and FOXP1 that are involved in BCR-signaling pathway in CLL B cells BCR BASH CD22 LYN SYK PLCG2 CD19 PMC11312688__F3 Proposed Rearticulation of the Mechanism for Radiation-Induced Fibrosis: Initial radiation exposure initiates at least three distinct pathways NOX3 DUOX1 IL33 DUOX2 SSB NOX4 NOX5 IFNG PMC2972642__F2 REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy F2 EEF2 CCND1 ARHA MEF2C INSR PMC11312688__F2 Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention KEAP1 ACE2 SIRT1 ADAM17 PMC3292920__F1 Diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance HEL-S-61p MTR VIT PMC8223458__F5 Long non‐coding RNA HOTAIR/microRNA‐761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma AGO2 PMC5040593__F3 Four pathways for double-stranded break (DSB) repair.Nascent DSBs are first recognized by ATM and the MRN complex that initiate a series of DNA damage response events that aim at arresting cell cycle and recruiting DSB repair proteins RIF1 BRCA2 PARP2 RAD52 PARP1 WRN BRCA1 PMC5859976__F1 Screenshot of PathwayMapper RIT1 PIK3R1 PI3 BAD IGF1R MAP2K1 RPS6KA1 EGFR PTEN INPP4B AKT3 PMC11587691__F1 Glucose metabolism in cancer cells ALYREF F2 CREB1 HIF1A MTOR HEL-S-133P STAT3 HEL-S-68p PMC11587691__F2 Lipid metabolic pathway HEL-S-26 FADS2 SCD GLS2 ACSS2 ACLY HMGCR CD36 PMC8440458__F2 Farnesoid X Receptor (FXR) agonists in non-alcoholic hepatitis FGF19 FGFR4 CYP7A1 PMC12042381__F1 Neospora caninuminfection induced significant changes of metabolic profiles in caprine EECs HEL-S-30 PGM2 ENO4 ENO1 OGDH HEL-S-87p HEL-S-133P HEL-S-162eP PMC5341794__F1 PD-1 signaling APC ZAP70 IL2 PMC6538535__F3 Menin-associated pathways with potential targeted therapies SST CDKN2C CDKN1B JUND GAS1 AXIN2 SOS1 MTOR PMC4259948__F1 Schematic summary of the molecular mechanisms of HLJ1 in suppressing lung cancer tumourigenesis NPM1 CD44 CCNG2 STAT1 HMGA2 HEL57 CDKN1A MMP2 BCAT1 JUND YY1 TXNIP TFAP2A SESN2 CALD1 PMC6458279__F5 Overview of the ferroptosis pathway and potential targets for pharmacological inhibition GPX4 HEL-S-64p HEL-75 PMC4525315__F8 Model representing the implication of the GSK-3/Beta-catenin axis in IRF3-regulated RLR-dependent antiviral innate immunity TBK1 GSK3A IRF3 MAVS PMC8740689__F1 Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug Development PC FOS DHFR DHPS PMC7536827__F2 Proteins associated with neurotoxicity and neurodegeneration CUTA MTOR CP PMC6458279__F7 Autophagy pathway and potential targets for pharmacological modulation TFEB ATG12 ATG10 TG DKFZp686F0183 PMC6458279__F1 Apoptosis pathway and potential targets for pharmacological modulation BAD TLR4 FOXO3A HTRA2 FADD BAX CD36 PMC4296672__F7 Estrogen Receptor-alpha 36 Mediates the Anti-apoptotic Effect of Estradiol in Triple Negative Breast Cancer Cells via a Membrane-Associated Mechanism PC LPA LPAR1 LPAR3 PMC5776175__F9 Model for Brucella Omp25 modulation of tumor necrosis factor (TNF)A suppression in porcine and murine macrophages TLR4 TRAF6 MYD88 PMC7156766__F5 Purine alkaloid metabolic pathway ND3 ND2 APRT PMC2829054__F7 Cdk2 Is Required for p53-Independent G2/M Checkpoint Control CDC6 CDK2 ATRIP CDC2 ATR PMC8087567__F1 How the love of muscle can break a heart: Impact of anabolic androgenic steroids on skeletal muscle hypertrophy, metabolic and cardiovascular health EGFR IRS1 PMC8138133__F6 Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells GPX4 COX4I2 SLC7A11 SLC3A2 PMC7536388__F7 Interrelations between profibrotic Smad2/3-dependent and anti-fibrotic Smad1/5/(8)9-dependent pathways in HBFs SMAD2 GC SMAD4 BMP7 SMAD1 DKFZp781O1323 PMC9563963__F3 Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells TUG1 AKT3 PMC6676114__F6 RNA MODOMICS and heterogeneity of tumors YTHDF2 YTHDF1 EGFR MYC BCL2 EIF4E PMC6132177__F1 Autophagy pathway ULK1 PROC ULK2 UVRAG MTOR PMC9131992__F4 Non-structural proteins of bovine viral diarrhea virus IRF3 MAVS PMC9655337__F6 Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis TLR4 TRAF6 MYD88 TNF PMC7605157__F2 Mechanisms responsible for the cytoprotective and antiinflammatory effects of PARP inhibitors in nononcological diseases ATM FOS CCL5 RNF146 CCL2 PARG JUN PMC3281082__F7 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer DDR1 MTOR PMC11671467__F3 EGCG-Mediated Pathways Targeting Oxidative Stress TNF HES1 PMC5576431__F3 Downregulation of the neurotrophin-MAPK signaling pathway in DPN BAD NGF FRS2 CRK PMC11671467__F5 EGCG in inhibition of cancer growth PTEN TNF MTOR BAX PMC11375560__F4 LOX activity in promoting tumour progression in breast cancer BMP1 SRC CRK STAT3 PMC5729532__F3 P53–p21–DREAM–E2F/CHR pathway E2F4 CDKN1A FOXM1 E2F2 E2F5 E2F3 PMC3775648__F4 Major elements of the Rho signaling pathway ARHGAP4 EPHA1 ARHA PMC12086034__F4 Visualize the KEGG enrichment results and mark the positions of hub genes BAD VEGFA PTEN MTOR HRAS RXRA AGER MAFK HEL-S-11 GC APP CASP9 CHAD GAL PMC7767789__F3 Metabolic abnormalities induced by hyperglycemia IGF1 HEL-S-162eP PMC5364987__F2 Different pathogenic roles of ER-resident and cell surface HLA-B27 dimers KIR3DL2 B2M IL23R PMC6387347__F1 One proposed mechanism for how vascular endothelial growth factor/neuropilin (VEGF/NRP) signaling impacts cancer stem cell (CSC) function independently of VEGFRs BMI1 RAC1 NRP2 PMC6046285__F1 Major signaling pathways activated through IGF-1R and EGF-R in adrenocortical carcinoma EGF IGF1R IGF1 IGF2 EGFR MTOR IGF2R PMC8201055__F2 microRNAs in the Regulation of Melanogenesis GSK3B GRB2 TYRP1 MC1R PMC3046768__F2 Schematic of the base excision repair pathways present in mitochondria FEN1 DNA2 PMC3775648__F1 Major elements of the canonical Wnt signaling pathway WNT1 WNT7A GSK3B WNT9A DKK1 DKK2 FZD1 FRZB FZD9 WNT4 WNT8B FZD2 FZD7 WNT7B WNT16 DKK3 WNT9B APC LRP5 LRP6 FZD4 WIF1 WNT10B DVL1 FZD5 DKK4 WNT3 WNT3A KREMEN1 WNT8A AXIN1 WNT10A WNT2B FZD8 PMC10889208__F1 Heterogeneity of the dermal fibroblast population PDGFRA LRIG1 FBN1 HEL-S-92n FGF7 PMC9461128__F5 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential KCTD1 KCTD15 YEATS4 TF CITED2 PMC3775648__F3 Major elements of the noncanonical Wnt/Ca2+signaling pathway PRKCZ GNB2 PPP3CA PPP3CC GNA14 GNAT3 GNG7 PLCG2 PRKCA FZD2 PRKCI GNA13 GNGT2 GNG3 GNG8 PLCB4 GNA11 GNA15 GNAT1 PRKCB PPP3R1 GNAI3 GNAO1 PRKCH GNB1 GNB4 PLCG1 PLCB3 PRKCE NFATC4 GNG13 GNB5 PPP3R2 GNG10 GNGT1 GNAI1 GNB3 PLCE1 GNAZ GNG11 GNAL PLCD3 GNG5 CAMK2D NFAT5 CAMK2G PRKD3 PRKD1 NFATC3 GNG12 NFATC2 GNAT2 GNAS CAMK2A PMC9461128__F3 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential TH PNMT DBH PMC3775648__F2 Major elements of the noncanonical PCP Wnt signaling pathway MAPK9 MAPK8 MAP2K4 MAP3K11 CELSR3 ROR1 CELSR2 WNT4 ROR2 VANGL1 ROCK2 MAP3K1 MAP3K6 DAAM2 MAPK10 MAP3K7 ARHA MAP3K10 RAC1 MAP3K13 MAP3K12 DVL1 DAAM1 MAP3K2 MAP3K14 MAP3K8 WNT5B PRICKLE2 PMC7768045__F4 Intramembrane proteolysis in cancer related signaling ERBB4 ADAM10 ADAM17 PMC9461128__F2 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential UBC CITED4 CITED1 KCTD1 TFAP2B SYT4 MYC YEATS4 CITED2 PMC5055500__F2 Diagrammatic illustrations of CCN1 signaling involved pancreatic cancer progression via CCN1-Notch1-SHh axes CYR61 CCNI PTCH1 SHH SMO PMC7858151__F8 MAPs alleviates AFB1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers KEAP1 BAX PMC5357196__F3 Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis NDP PNP PMC2902700__F6 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE STIMULATES THE PROLIFERATION OF COLORECTAL CANCER CELLS GIPR GIP MTOR PMC6213986__F2 Pharmacodynamic mechanism of TCM against HSV-1 IRF3 MTOR ELF4 TLR3 MAVS PMC6363022__F1 Summary of interactions between ECM remodelling and kinase activity HTRA1 EGF EGFR TGFBR1 CD44 TGFBR2 SRC RHO DDR2 STAT3 PMC6199805__F5 GABAergic synapse signaling pathway, with the enriched target genes highlighted in red TH PMC7381633__F6 Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway OSBPL3 RHO HIF1A PMC5817864__F1 Rapidly induced cell autonomous bypass signaling EGFR FGFR3 IL6 JAK1 FGFR2 STAT3 PMC7346753__F2 Multiple targets and multiple signal pathways of Huang Qin-Bai Shao (HQ-BS) herb pair against cancer CHRNA7 PPP3CA NR3A2 HSP90AB1 GSK3B MAPK14 PTGER3 CCL2 DRD1 HMOX1 KDR NCOA1 NOS2 ADH1C JUN SELE ADRB1 PTGS2 GSTM1 VEGFA ADRB2 IL6 TNF EGLN1 RXRA GSTM2 ADRA1B CYP2C9 CHRM3 CYP3A4 CDK2 MAEA NR1C2 BCL2 ADRA1A HTR2A PPARG PMC7481593__F2 Ferroptosis modulation in tumor GPX4 PHKG2 KEAP1 FTH1 SLC7A11 CISD1 MT1G IREB2 SLC3A2 PMC3465072__F1 Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge MAP3K1 IGF1 EGFR GRB2 TRAF6 RAF1 TGFA TRAF2 IRS1 PMC7481593__F1 Ferroptosis GPX4 LPCAT3 STEAP3 FACL4 HEL-S-64p ADA IREB2 SLC3A2 TF HMGCR PMC9038189__F5 Cyst lineage recovery after ablation EGF EGFR PTEN PMC8561869__F2 FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases IRS4 IGF1 IRS1 PMC9026172__F5 Pharmacodynamics, Network Pharmacology, and Pharmacokinetics of Chinese Medicine Formula 9002A in the Treatment of Alzheimer’s Disease PTGFR TLR9 HDAC3 CSNK2A1 GRM2 CASP9 HDAC2 CHRM2 NOS2 ABCB1 OPRD1 MAPK10 TNF RXRA CNR2 BCL2A1 CYP2C9 CHRM1 GRIN2B HTR2A SIRT1 CDC42 TERT S1PR2 CASR NR3A2 S1PR4 ACHE CNR1 CYP1A2 THRA RARA RARB AHR CYP2C19 PTPN1 APP ABCG2 CYP17A1 OPRM1 ADRA2C PTGS2 NR3C1 PTGES NR1C1 HDAC1 CASP3 CTSG CXCR3 PTPRC PLA2G1B RELA TBXA2R PPARG MME PMC9628328__F1 IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NFKB–Induced Inflammation TLR4 IRAK1 TRAF6 MYD88 MAP3K7IP1 PMC2696328__F5 Proposed model for the effect of HPTE in the granulosa cell GREM1 IGF1R SF1 FSHR PMC550674__F2 Apoptosis mediated by death receptors requires the FADD adaptor molecule TRADD TNF TRAF2 FADD PMC3130335__F1 MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells IGF1R EGFR RAF1 IRS1 PMC8487456__F4 Quality control and recycling of peptidyl-tRNAs on stalled ribosomes NEMF ANKZF1 ELAC1 LTN1 ANGEL2 HSF1 TRNT1 PMC5802164__F6 Kyoto Encyclopedia of Genes and Genomes pathway of hsa04622: RIG-I-like receptor signaling pathway TBK1 IKBKE PIN1 TANK IKBKG CHUK DHX58 TRADD MAPK8 MAPK14 TRAF3 TRAF6 DKFZp686F0183 ISG15 CYLD CASP8 MAP3K1 ATG12 IRF7 NLRX1 MAP3K7 DDX3X IRF3 CASP10 TRIM25 SIKE1 RNF125 NFKBIA AZI2 NFKB1 IFIH1 TRAF2 TBKBP1 FADD MAVS PMC371122__F7 Signaling pathway of UCP1 transcription in brown fat UCP1 ATF2 RXRA PMC8118165__F1 Pembrolizumab in unresectable or metastatic MSI-high colorectal cancer: safety and efficacy CD80 LAG3 PMC3141076__F6 Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression DGAT2 PCK1 PDK2 PKLR DCT MOGAT2 FASN GPD1 HEL-S-162eP PMC4602327__F1 Major pathways of apoptosis HEL-S-62p BAD C9 TRADD C7 C6 MCL1 TRAF2 FADD BAX PMC7996143__F11 Activation of Sirt1 with SRT1720 can handle the high fructose diet-induced insulin resistance, oxidative stress, and mitochondrial dysfunction through Sirt1-PGC-1Alpha-NRF1- Sirt3-TFAM signaling pathway NRF1 TFAM SIRT3 PMC2987346__F2 RSK signaling pathway BAD L1CAM ATF4 EEF2 GRB2 EIF4B PMC3522801__F2 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis PML ATM CDK2 CDC2 ATR BRCA1 BAX PMC6103408__F9 IFNG-induced autophagy is regulated by HMOX1 ULK1 TFEB SQSTM1 IRGM MAPK3 MAPK14 EIF2AK4 MAPK1 JAK1 CEBPB IFNG PMC8005112__F2 Mechanisms of synergy between small molecules and immune checkpoint inhibition in melanoma BRAF APC PMC3522801__F1 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis ATM MDM2 RAD50 H2AX MRE11A BRCA1 BAX PMC7190807__F9 Hypothesis diagram of the regulatory mechanism of Twist1, Tie1, Tie2, Angs, and Akt/Foxo1 in endothelial cells TWIST1 PMC4180659__F1 Perpetuation of innate immune responses in sJIA TRAF6 MYD88 TNF PMC4860843__F8 Disruption of TGF-Beta-mediated tumor suppression in SCLC cells ASCL1 SMAD2 SMAD4 PMC3324026__F1 Annotation of the insulin/TOR network in Apis showing methylated and differentially methylated genes TSC2 RICTOR TSC1 BRAF ALK PTEN HIF1A MTOR EIF4B RHEB PMC7022656__F9 Cross-talks between distinct signaling pathways activated within different ER-to-nuclear responsive networks to the classic ER stressor TU GCLM DDI2 DDI1 NRF1 ATF4 EIF2A NGLY1 XBP1 PMC11880501__F7 Working model ZFP36 LRP5 PMC6756575__F4 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis NPY1R GNG13 CSF3 POSTN MMP9 CXCL8 IL6 HMOX1 P2RY14 ANGPT1 CXCL13 C5AR1 opn CCL19 THBS1 CD19 PMC6756575__F3 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis SLC43A2 IRX3 GGH SBF2 PRRG4 FCRLA POSTN F2RL3 PRRT2 HSPB3 DNTTIP2 SOX4 SLC35A1 KRT4 BCHE FOXE1 PHLDA2 SPOPL AKAP12 ACTG2 ANKMY2 ITM2A ROBO2 SPPL2B ITPRIPL2 HOXA2 KIAA2012 NAP1 HMCN1 TMEM201 PTX3 PLN CIRBP EDNRB SBSPON PTCH1 C7orf11 RND1 COMP TNFRSF17 HTR2B SUMO1 CRHR2 FOLH1 TANK CX3CR1 SFN CSF3 ACTA2 DST FIBIN RAB23 ASPN SFRS3 DKK2 PDF SLIT2 CXCL13 NR2F2 INMT ITPKC SCN4B ATM LDB2 opn LTBP2 RDH10 MYOC TSN SPAST KRT16 SDC1 LIF HS3ST2 LRRC2 CHMP4B KRT7 MRPL47 LMF1 GNL3L DDR2 AGR3 MED21 CYP2E1 PAX4 ZNF652 EFS AGER ENPP2 OGT ECM2 PPIB CBLN4 TSNAX CYCS PMC7226501__F8 Regulatory model of VP4 in antiviral signaling in grass carp TBK1 IRF7 IRF3 MYD88 PMC8006920__F4 Pathway enrichment of hubs: The common pathway (red rhombus) shared by three protein hubs (yellow rectangle) extracted from the metalloprotein network HSP90AB1 MTOR ELL PMC7022656__F1 Inhibition of Nrf1 N-glycosylation by tunicamycin (TU) in the endoplasmic reticulum (ER)- to-nuclear signaling responses NRF1 ATF4 EIF2A XBP1 PMC10508215__F1 AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3B,17Beta-Diol STS HSD3B1 CYP11A1 AKR1C1 AKR1C2 CYP17A1 PMC8867758__F4 MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro BAD FOS PAK4 PMC6254932__F6 VHL-HIF-BNIP3 signaling pathway EGF VHL BNIP3 TGFA PMC5927447__F10 NF2 signaling pathway plays a pro-apoptotic role in Beta-adrenergic receptor stimulated cardiac myocyte apoptosis NF2 BAX PMC5596881__F2 Therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools E2F4 CXCL3 SORD WAS MYD88 HMOX1 HEL-S-61 FGFBP1 POLA1 CDCA7 CEP192 GSTA3 CSF2 BIRC6 RAD21 HEXA AREG GCLC IL1RN GTF2I TOMM20 PRSS35 MCM5 TIMP1 CDKN1A HEL-S-72p SRXN1 PRDM8 SLC7A11 RAG1 FIBIN GLIPR1 IFT80 MAP4K1 AOX1 UBC RRM2 GDF15 BSCL2 CXCL6 PRKDC MKI67 CD3E ME1 CD14 EGR1 HEL-S-25 NFAT5 PIR FTL IL6 NFATC3 FAT3 ANGPT1 WAC LCK TRAT1 AAG1 PMC5858488__F1 MTOR signaling pathway TSC2 RICTOR TSC1 EGFR PTEN MTOR MLST8 PMC10377491__F1 Landscape of Small Leucine-Rich Proteoglycan Impact on Cancer Pathogenesis with a Focus on Biglycan and Lumican HMGB1 FAP FBXW7 STAT3 PMC3128635__F2 Crosstalk and feedback in ERK and PI3K signaling downstream of RAS PTEN IRS1 PMC3128635__F1 RAS signaling to the PI3K pathway TSC2 RICTOR BAD GRB2 PTEN MTOR IRS1 PMC4447220__F6 Conceptual model of the effects of 15-LOX-1 on the PPARD–IL-6/STAT3 signaling pathway in relation to colorectal tumorigenesis MUC1 NOTCH3 STAT3 PMC10341567__F4 Major pathways and interactions regulated by BACE1: (A) Notch signaling pathway, (B) Amyloidogenic pathway, and (C) NFKB pathway BACE1 GSK3B NOTCH1 PMC10341567__F3 Major pathways and interactions regulated by GSK3B: (A) Wnt/B-catenin pathway and (B)PI3K/Akt/mTor pathway APC GSK3B MTOR PMC10341567__F6 Major pathways in which ABCA1 plays an important role for cholesterol transport in brains: (A) Reverse cholesterol transport pathway, (B) LXR/RXR pathway, and (C) SREBP2 pathway SCARB1 ABCA1 CD36 PMC10341567__F5 Major signaling pathways that regulate SREBP2 activation during cholesterol synthesis: (A) P53 pathway, and (B) Akt pathway TSC2 GSK3B ARHA ABCA1 RHEB PMC8795088__F5 Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease HTT BDNF HEL-S-29 PMC10341567__F7 TREM2/DAP12 pathway GSK3B SYK APOE PMC9038119__F1 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species OGA OGT HEL107 HEL-S-162eP PMC8045214__F9 Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival ZNF71 CTCF MYC ZNF610 SUZ12 GATA2 PRC1 AHR DKFZp686D2168 ZNF423 REST SP3 KLF8 PMC11969919__F4 Transcriptome profiles of blastocysts originating from oocytes matured in follicular fluid from preovulatory follicles of greater or lesser maturity MGST1 PCDH17 APC KIF3B CCND1 DBT AXIN2 KLF3 HHEX PMC9038119__F3 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species NAPRT NAMPT KYNU HPD AFMID PMC9038119__F5 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species ADSL PAICS APRT XDH ADK PMC10341567__F1 Main pathways involved in cholesterol transport involved in Alzheimer’s Disease BACE1 CYP46A1 GSK3B APP ABCA1 APOE PMC8913803__F3 Signaling pathways and targeted therapy for myocardial infarction NLRP3 TRAF6 MYD88 TIRAP PMC8913803__F2 Signaling pathways and targeted therapy for myocardial infarction NOTCH2 NOTCH4 CS GSK3B NOTCH1 PTEN EZH2 NOTCH3 JAM2 PMC10834963__F8 Proposed signaling mechanism for the effects of amlexanox on LPS-induced neuroinflammation in BV2 microglial cells CXCL10 CCL2 STAT3 PMC5272937__F1 The HCV interactions (both direct and indirect) on the hepatocyte insulin signaling pathway PI3 PKD1 MTOR IRS1 PMC5419442__F9 Possible Signaling Pathway that Mediates FSH-Induced Meiotic Resumption of Mouse OocytesAfter binding with its membrane-integrated receptor in cumulus cells, FSH uses PKAII as a downstream mediator after a transient increase of cAMP EGFR FSHR PMC6887669__F1 Two‐signal model of inflammasome signaling NLRP3 IL16 IL1B PMC8765442__F2 Heart Failure with Targeted Cancer Therapies: Mechanisms and Cardioprotection RET FLT3 PMC6735914__F3 DAXX in cell death PML ULK1 HIPK2 FTH1 TGFBR1 TRIM21 TGFBR2 RIPK3 RIPK1 PIAS1 BCL2 TRAF2 FADD PMC8100458__F2 Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy HGF APC MMP9 ARHA NOTCH3 CDC42 PMC8913803__F5 Signaling pathways and targeted therapy for myocardial infarction STAT1 EPO JAK1 STAT3 PMC8913803__F4 Signaling pathways and targeted therapy for myocardial infarction ROCK2 KEAP1 ROCK1 ARHA POR NOTCH3 PMC8913803__F7 Signaling pathways and targeted therapy for myocardial infarction ERBB2 PITX2 SHH SRC SMO LATS1 SKI LATS2 PMC8913803__F6 Signaling pathways and targeted therapy for myocardial infarction SMAD2 APC GSK3B KLF5 LRP5 SMAD4 LRP6 DKK2 PMC5869932__F2 Roles of ZBTB proteins in B-cell development, differentiation, and function ZBTB7A PC PREB ZBTB1 PAX5 IL7R BCL2 IRF4 BCL6 ZBTB24 ZBTB32 PMC3757945__F3 Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair IGF1R APC GSK3B LATS1 LATS2 PMC8948957__F2 Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis PFAS ADSL PAICS HEL-S-70p PMC2661568__F6 Schematic model of sequential hippocampal aging changes SOAT1 APOD APOE PMC4185356__F1 Control of endotoxin tolerance by AhR IDO1 TLR4 AHR TDO2 PMC3904516__F8 LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NFKB and BMP/Smad Signaling TLR4 RUNX2 BMP2 SMAD4 MYD88 COL1A1 SMAD1 IL1B PMC10886830__F7 Toll-like receptor (TLR) signaling pathway with a focus on TLR4 TLR4 TRAF6 MYD88 TNF PMC6835115__F3 Targeting PKCι-PAK1 in EGFR-mutation positive non-small cell lung cancer PAK1 ECT2 YAP1 EGFR SRC RAC1 CDCP1 AXL STAT3 PMC6311107__F2 Simplified model of the molecular pathways by which pazopanib and AR42 combine to kill cancer cells TSC2 ULK1 BAD ATM HDAC10 EIF2A HDAC11 HDAC2 RAF1 MTOR BAX PMC6478125__F1 RUNX3 and p53 act independently and in concert to elicit their tumour suppressive function RUNX3 ATM ATR BRD2 PMC6311107__F4 Simplified model of the molecular pathways by which neratinib and valproate combine to kill cancer cells ULK1 ERBB4 PDGFRA ATM ERBB2 ERBB3 EIF2A MTOR DKFZp686F0183 PMC8634264__F2 Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects KEAP1 ACE2 TMPRSS2 PMC4773033__F2 Comprehensive picture showing gene expression changes and crosstalk of pathways associated with Igf1 and Pacap rescue of apoptotic CGNs FGF21 NGF CX3CL1 HSPA2 GRIN3B CORO1A ITK CACNA1S FYN FGFR1 WNT4 SHH GSTA3 AGXT CERS2 PIPOX HRAS ITGB1 IRS1 CXCR3 GSTM2 DUSP5 RAP1A IGF1 SUFU CXCR4 GALR2 PTCH1 GRB2 PSPH HEL-S-51e HEL-S-283 HSPA1A WNT5B PMC4993794__F1 Tarp protein mediated signaling pathways implicated in chlamydial entry and development SRC SYK SOS1 TARP VAV2 PMC3788606__F3 TGFB signaling TGFBR1 TGFBR2 RHO SKI PMC12066627__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections ChAT SPIB PLCG2 IL25 PMC3306981__F1 Summarized the signaling mechanisms of various matricellular proteins contributing to cancer progression SPARC TNC LEF1 HEL-S-28 RHO PMC4839364__F1 (T)cell-inflamed and non-(T)cell-inflamed phenotypes CXCL10 CXCL9 CD8A PMC4497751__F2 MicroRNA regulation of lymphocyte tolerance and autoimmunity TSC2 BTK BAD TSC1 PHLPP2 PTEN MTOR PTPN22 PMC9250769__F1 Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis KIN MATK PMC6610456__F1 TRAFs in IL-17 signaling pathway TRAF5 EBP EGFR TRAF3 TRAF6 USP25 TRAF2 IL17RC ARID5A TRAF4 TTBK1 TAB3 PMC8283906__F3 Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target TLR9 MPO CCDC25 PMC10731584__F7 Simplified de novo sphingolipid biosynthesis pathway UGCG FA2H KDSR PMC6505627__F2 BCR: a promiscuous fusion partner in hematopoietic disorders RET FGFR1 BCR PDGFRA PMC11273247__F11 Sodium sulphate ameliorates hypercholesterolemia and hepatic insulin resistance in mice fed an HCD FGFR4 IRS1 CYP7A1 PMC4751708__F2 Gene networks NUMB RBPJ DTX3 CARD6 DLL3 RIPK2 PDPK1 ADAM17 IFNG HES1 CREBBP CARD9 MDM2 SNW1 PIK3CA DVL2 PSENEN NCOR2 PMC8270322__F1 Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological Malignancies PIGF CDK2 BAX PMC6338329__F7 Mechanisms for human cervical epithelial cells (HCEs)-mediated HIV suppression in macrophage STAT2 IRF7 IRF9 IRF3 IFNAR2 IFNAR1 TLR3 STAT1 ISG15 OAS1 OAS2 TYK2 STAT3 PMC3643422__F1 Illustration showing the overall sex hormone metabolic pathway and subpathways SHBG NR3A2 PGR STAR PMC7261174__F10 IKBKE mediated AR signalling IKBKE MYC LATS2 PMC4334626__F1 Proposed schematic model showing how the crosstalk between healthy or oxidized/senescent red blood cells (RBCs) and immune cells may exert anti- and proatherogenic effects, respectively TH ICE1 IL16 PMC3220493__F6 Schematic model in which FGF2 stimulation of osteoblast differentiation is partially through modulation of the Wnt/Beta-catenin pathway RUNX2 ATF4 FGF2 GSK3B LRP5 LRP6 WNT10B PMC5270455__F15 Directional pathway satisfying TIM of Table EGFR TGFBR2 HDAC1 PMC5270455__F14 Directional pathway satisfying TIM of Table EGFR TGFBR2 HDAC1 PMC4286365__F1 Biosynthetic and recycling routes in MDCK cells: the new paradigm LDLR PIGR PMC7355786__F3 Mechanism of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway TSC2 TSC1 PTEN RHEB PMC7859603__F1 DisGeNET contains a list of diseases associated genes that have been collected based on the presence of genetic overlaps between diseases MYB MHC2TA HLA-G EGFR CCL2 CEBPB IFNG NLRP3 MMP3 NR1i1 IL17A IL2 NOS2 ABCB1 JUN SELE CD14 IL10 TBX2 APC IL6 TNF TG APOB IL3 RELA BCL2 IL2RA PPARG TGFBI STAT3 PMC3121446__F6 P53 activation by NML-MYBBP1A in response to glucose limitation MYBBP1A MDM2 PMC5737867__F5 The involvement of the brain-derived neurotrophic factor (BDNF)-glycogen synthase kinase-3B (GSK-3B)-Beta-catenin pathway in the antidepressant-like effects of Morinda officinalis oligosaccharides (MOs) and resilience to stress MOS GSK3B BDNF PMC7240858__F1 Innate immune checkpoints influencing DC function in the TME MUC1 HMGB1 SIRPA CD47 PROS1 LILRB1 BTLA CD80 CD24 PMC9608343__F1 Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease WNT3A RUNX2 MSC PTH PDF WNT10B PMC8126571__F1 Bidirectional microglia–neuron interactions in the healthy or stressed brain HMGB1 CSF1 BDNF IL1B PMC86258__F8 Shc/Grb2/Gab2/PI-3K Akt pathway IL15 IL3 GAB2 GRB2 SHE IL5 PMC5935908__F8 NRP-1/TNC/Integrin B3/FAK/Akt/NFKB schematic signaling pathway TNC ITGB3 NRP1 GSK3B ABCG2 PMC7417304__F4 Emerging roles of Hippo-YAP signaling in the modulation of innate anti-tumor immunity IL13 LATS1 MYD88 IL4 CSF1 PMC6121402__F1 Mammalian target of rapamycin (mTOR) pathway TSC2 TSC1 TBC1D7 IRS1 RHEB PMC7417304__F1 Signaling mechanism and regulation of the Hippo pathway in drosophila and mammals LATS1 MOB1A PMC3109273__F1 Host cell death pathways targeted by L BNIP3 SDHA BAX PMC7417304__F3 Hippo pathway in innate antiviral immunity TBK1 CGAS TRAF3 IRF3 LATS1 MYD88 LATS2 MAVS PMC7417304__F2 Hippo pathway in innate anti-bacterial immunity TBK1 IRF7 TRAF3 TRAF6 IRF3 IRAK4 ECSIT RAC1 MYD88 PMC4012154__F1 Signaling pathways involved in microglial phagocytosis SYK IRAK4 MYD88 CDC42 PMC9477794__F2 Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy NLRP3 RELA MYD88 IL1B PMC8005405__F2 Mechanisms regulating ROS in LSCs TPO FIS1 PMC3197200__F2 Intracellular signaling pathways regulating growth IGF1R IGF1 FGFR3 PTEN EIF4E PMC8587556__F4 Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease APC GSK3B LRP5 LRP6 RYK ROR2 ROR1 PMC3214149__F3 Schematic overview of CagL and CagA-mediated signal transduction pathways involved in H CSK ASB1 RAC1 CRK PMC8618071__F7 Fungicidal Activity of Recombinant Javanicin against Cryptococcus neoformans Is Associated with Intracellular Target(s) Involved in Carbohydrate and Energy Metabolic Processes PDC CS HBD PMC8056183__F2 Cell death pathways and viruses: Role of microRNAs ULK1 MTOR DEPTOR MLST8 PMC4989102__F6 Network motifs that are coordinately regulated by the miR-17–92 cluster MAP3K1 RASA2 PRKX RPS6KA5 MAP3K5 CRK TAOK1 NLK DUSP5 PPP3R1 DUSP10 RAP1A MAP4K3 JUND DUSP7 TF PMC8056183__F1 Indirect effects of viruses on the apoptotic pathway through deregulation of cellular miRNAsmiR-2861 increased the apoptosis of cervical cancer cells through the PI3K/AKT pathway by targeting EGFR BAD TRADD SMAD2 SMURF2 SMAD4 SRC BCL2 PTEN TRAF2 FADD BAX PMC6490153__F6 Pathway summary of a host defense mechanism response to bacterial meningitis caused by Streptococcus pneumoniae RB1 BDNF BAX PMC10340243__F5 The main metabolic pathways of unsaturated fatty acids ChAT ALOX12 ALOX12B PMC7364557__F2 Model for tau pathogenesis NLRP3 FYN CX3CR1 CDK5 PMC7364557__F1 Model for ABeta-induced neurotoxicity and glial response in AD CD47 FYN TLR4 CASR LILRB2 APP SYK AQP4 APOE EPHB2 EPHA4 CD36 PMC2698768__F9 Model of CD28 signaling pathways initiated by the distal and proximal motifs GSK3B PMC5295004__F8 Proposed model of selected miRNA action on the regulatory T cell pathway RUNX3 CTLA4 DKFZp781O1323 FOXP3 PMC3580185__F7 Working model for the role of TAK1 lysine-72 in the negative regulation of TNFAlpha-induced NFKB activation TRADD RELA CSA2 REL TNF TRAF2 PMC8347056__F3 Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology ORAI3 ORAI1 STIM1 PMC5490254__F2 WNT and SHH signaling pathways APC SHH SMO PMC4375971__F1 Obesity genetics in mouse and human: back and forth, and back again POMC MRAP2 NPY AgRP MC4R MC3R LEPR SIM1 SH2B1 TUB BDNF STAT3 PMC5370457__F1 Mechanism of signaling transduction of vascular permeability MLPH ARHA TNF CDC42 PMC5646121__F3 Direct and indirect targeting of the B cell receptor signaling pathway BTK BCR BASH SYK PLCG2 MTOR CD79B CD19 PMC6277481__F1 Genetics and molecular pathways for PPGLs Pathways for the New Genes; Placing the New into Perspective RET MAX APAF1 MYC HRAS SDHAF2 TMEM127 PMC8891265__F1 Diet, lipids, and antitumor immunity PTMS SCD ACLY SLC25A1 HEL-S-5 PMC2978917__F7 Signaling pathway and transcription factors involved in HPR1 gene expression in cancer EGR1 EGFR SP1 SPIC PMC4259002__F4 Epidermal growth factor receptor pathway EGFR MTOR STAT3 PMC10478470__F2 HMGB1 and TLRs signaling pathway TLR8 HMGB1 TLR5 TLR7 TLR4 TLR9 MYD88 TLR1 TNF TLR3 PMC6329348__F3 Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue C1D CAST TP53INP1 HEL-S-94n DUSP14 VWF REST DKC1 CDC2 HEL-S-133P BPI ZNRF3 NEIL2 C16orf35 CKS2 ANGPTL4 GUCY2C HOPX PSMA2 AURKA GSTM2 MCM6 ERAP1 SUFU ERC2 EXOC4 VCP NEK9 CDH17 PMC8428079__F2 Targeting Beta-cell dedifferentiation and transdifferentiation: opportunities and challenges PDGFRA TRADD RELA RELB INS RAC1 TNF TRAF2 FADD MYLK CDC42 MAFA PMC9621333__F1 Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesis BCR HLA-DRB1 PMC2801177__F4 Identification of candidate molecular network for miRNAs most highly changed in response to DEP PLK2 HEL-S-89n NR5A2 BMP2 PITX2 NR3C2 TNPO1 PTEN SNAP25 CUL4A CEBPB CFTR BMPR2 TRPC1 ACVR2B DNAJA2 ZBTB44 NCOA1 NR3B3 GATA3 PMC2801177__F3 Subnetworks of select putative DEP-regulated gene transcripts show an enrichment of inflammatory response PROS1 GNG13 ROCK1 PRKAR1A PITPNB GRSF1 CNR1 RGS5 XDH CD40LG TACC1 AMPH CCL25 SCARB2 ARHGAP5 RBM7 VPS35 MCHR2 PITX2 WIPF1 PDPN HBEGF HMGCS1 TNF SOCS6 CUL4A CFTR GNG12 LRAT SNN DUSP5 TMEM109 CXCR4 ADCY6 SOX6 CP APPL1 PMC2242778__F5 Canonical pathway analysis ARHA CRK PXN PMC9636380__F1 Activation of RIPK3 by multiple stimuli RIPK1 TLR4 TRIM21 RIPK3 PELI1 PPM1B TLR3 ZBP1 MLKL PMC6085908__F1 Synaptic signaling pathways associated with autism spectrum disorder (ASD) UBE3A GSK3B HOMER1 PTEN EIF4E MTOR SYNGAP1 RHEB CACNA1C TSC2 NF1 TSC1 ARC BDNF PMC5415789__F6 CeRNA network modulates the PI3K/Akt signaling pathway EGFR VEGFA MYC PTEN RAC1 EIF4E IRS1 OSMR RHEB ATF4 RELA GRB2 CDK4 EIF4B SGK1 PMC6468516__F2 Metabolism in tumor cells CS GRB2 HEL-S-162eP PMC8221295__F6 Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation IL10 GSK3B VEGFA INS CREB1 MAP2K2 TYMP PTEN IL6 TNF FGFR2 FGFR1 MAP2K1 IGF1 CYP2C9 CYP2C19 HEL-S-44 IL2 MAPK1 IL1B PMC2822054__F1 How the PI3K-AKT and MEK-ERK pathways regulate apoptosis in EGFR driven cancers ERBB3 EGFR MYC MDM2 GRB2 CCND1 PMC4632093__F1 Nodes-and-connections strategy generating an interaction map of signaling molecule network required for the fulvestrant-induced MCF-7 cell apoptosis PRKCZ MAPK9 GRB14 ROCK1 CSK MYL2 F2RL3 NR3C1 MAP2K2 PAG1 CALM1 DAPK2 ERBB4 CAMK4 PAWR ATF4 BIK CAMK1D SRC MYLK3 STAT3 PMC8759533__F1 ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition ALK PTPN11 CCND1 MTOR CBL PMC4252654__F1 MANNOSE METABOLISM: MORE THAN MEETS THE EYE DPM1 GMPPB MPDU1 DPM2 DPM3 PMC8707026__F1 Molecular Rationale of Insect-Microbes Symbiosis—From Insect Behaviour to Mechanism TRAF3 TF PMC6300778__F8 JAK2/STAT3 mediated protection of APN against OGD ELL STAT3 PMC11878481__F1 Autophagy by mTORC1 and AMPK TSC2 ULK1 TFEB ATG12 ATG3 DKFZp686F0183 PMC8185197__F1 Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment ACACA FH ACACB VEGFA RPS6 SLC11A2 HEL-S-133P PMC9179253__F2 New Therapeutic Strategies for Adult Acute Myeloid Leukemia FGFR1 FGF2 FLT3 MTOR PMC5242532__F1 Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1 TP53BP2 AMOT CD44 AJUBA LATS1 RASSF6 LATS2 PARD3 FAT4 CRB1 PMC3673784__F1 Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition FZD3 CSNK2A1 BIRC5 SMAD2 GSK3B CER1 TNKS WIF1 DVL3 TNKS2 WNT2B JUN TCF4 PMC7012784__F2 Anti-tumourigenic JNK signalling SCRIB ROBO2 PMC4465694__F8 Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells SRC MTOR FOXO1 PMC9263135__F9 Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer AMER1 PRKCI PRKCZ MAP2 KEAP1 NFE2L2 FBXW7 E2F3 RET ATM TLE4 MDM2 CCND1 COMP OTULIN PMC7012784__F5 Upstream regulation of JNK signalling HEL70 PPM2C TRAF6 ATF3 RAC1 TNF TRAF4 PMC4059866__F4 Gene network generated by Ingenuity Pathway Analysis of 5 genes identified to be predicted targets of miRNAs associated with in vitro cisplatin resistance (fold change > 2, P < 0.05) in the current study SMC1A ANKRD17 TP73 SUMO1 PMC5302293__F1 Cell-cycle and DNA repair SFN FOXO3A BIRC5 GADD45A PTEN RB1 TNF CDK6 XRCC5 STAT1 CASP3 CDKN1A APAF1 CDK2 CCNB2 CASP9 CDK4 BNIP3 JUN PCNA MYOD1 CCNE2 BAX PMC4721605__F2 Key signaling pathways that regulate activity-dependent translation initiation in neurons TSC2 TSC1 IGF1 PAIP2 ATF4 EIF2A PTEN EIF4E EIF4B RHEB PMC2726720__F3 Interplay of TGFB, Wnt/Beta-catenin, Hedgehog, and Notch in stem cell differentiation and tumorigenesis SMAD4 CDK4 PMC7193059__F1 Neurotoxicity of local anesthetics in dentistry BAD FADD BAX PMC12218202__F6 Chlorophyll synthesis and degradation of tomato leaves in WT and slprr1 lines under SD or LD conditions UROD UROS POR CPO PMC7604390__F1 Model showing intracellular lipid metabolism and AA metabolism in ovarian cancer COX2 CIC LDLR FABP5 LPA ACLY FASN CD36 PMC12020288__F1 Mechanism diagram of RBPs in HCC NDRG2 EIF5A2 MSI1 EIF3A PTBP1 MEX3C HNRNPL EEF1A2 RPS7 RBM3 EIF4E GRSF1 FUS CCDC137 YTHDF1 SPATS2 PUM2 IGF2BP3 IGFBP2 PNO1 RALY STAT3 PMC7168513__F4 DENV‐mediated activation of the cytosolic DNA‐sensing pathway in DCs TBK1 CGAS IRF3 PMC12020288__F3 RBPs as potential therapeutic targets for HCC YTHDF1 RBM38 CLDN6 CLDN1 DTX3 IGFBP2 YY1 RBMX GRSF1 BLACAT1 TARBP2 PMC3131055__F1 Wolbachia-induced responses of specific cell types CD14 CXCL1 TLR4 TLR9 CD40 CXCL2 CD80 MYD88 IL1B TLR3 MAL PMC7168513__F1 Cytosolic DNA‐sensing immune response via cGAS/STING TBK1 CGAS TREX1 IRF3 PMC3870290__F4 Potential mechanism of AICD-mediated gene regulation HEL-S-62p MED12 LBP APP PMC5795380__F1 Protein subnetworks of Ras (the query protein) with Raf and ERK1/2 MAP2K1 BRAF MAP2K2 SHOC2 RAF1 SOS1 ARAF RGL2 PMC3870290__F1 Proteolytic processing of the amyloid precursor protein (APP) and Notch BACE1 APP PMC10908104__F2 ALS disease pathological signaling pathway HEL-S-44 C9orf72 FUS PMC5715491__F7 Pathways involved in apoptotic and EMT effect by genistein in HT-29 cells TWIST1 CDH2 BAX PMC10855445__F3 Interaction between ALR, NLR, and cGLR (cGAS/STING signaling pathway) NLRP3 CGAS USP21 NLRX1 IRF3 AIM2 NLRC3 PMC4049863__F3 Rho-GTPase signaling in leukocyte extravasation ARHA PMC5332883__F1 For PD-L1 modulation in HNSCC STAT1 PI3 PDK2 EGFR PTEN STAT3 PMC4786284__F6 Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway DHH SUFU SHH PMC9185718__F5 An effective nano drug delivery and combination therapy for the treatment of Tuberculosis CASP3 IRAK1 INHA MYD88 FADD HEL-S-5 PMC7613405__F4 Notch signaling pathway and the processes of lateral inhibition and induction NOTCH2 NOTCH4 FH NOTCH1 NOTCH3 PMC3673714__F2 miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy TIMP3 PTEN PMC6826985__F7 Gene activities in the TGF beta signaling pathway BAMBI FST NODAL PITX2 SMAD2 TGFBR1 MYC SMAD6 SMAD4 SKP1 ARHA IFNG PMC6826985__F6 Gene activities in the calcium signaling pathway PLN BCR CAV3 APLN MCU CAV2 PMC1869626__F2 Pathway analysis was performed using PathwayStudio software by importing three of the 32–up-regulated genes in our list AHR SCD ASNS PMC7358455__F9 Schematic illustration showing the mechanism of melatonin(Mel)sensitises shikonin(SHK)-induced cancer cell death ME1 SIRT3 PMC6826985__F5 Gene activities in the cytokine-cytokine receptor interaction pathway EPOR CCR2 GHB2 EPO CSF3 IL34 FLT4 CCL2 KDR AMH IL20RA IL2 LEPR IL4 GAL SP1 ACR IL2RB IL10 INHBC KIT BMP2 LIF VEGFA LTB TRO TNF TNLG7C CNTF EDAR LEP LTA IFNK CD40 IL11RA OSM MPL LTBR INHBA INHBE PMC3961361__F8 MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection TRADD CYLD TRAF3 TRAF6 IRF3 MAVS PMC4209417__F2 Insulin-like growth factor-I receptor signaling pathway BAD GRB2 PTEN MTOR IRS1 PCNA PMC9313262__F5 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) PLAUR TTK ARHGAP18 MAP2K3 NOP2 AURKA ITGA2 KIF11 CALM1 TNC VWF HEL113 SERPINB2 PMC9313262__F4 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) PLAUR NPM1 TPM1 HMGCS1 DKK1 MAP2K3 MTA2 CRK GRN ITGA2 CCDC80 STAT1 DCN HEL-S-44 CCND1 HEL113 FNDC3B ITCH PMC6923859__F3 Wingless (WNT)-signaling pathway as a central way to Braford anti-tick resistant (R) response HGF EGFR WNT7A TBX3 GSK3B MYC ATF1 CCL2 OLIG2 CCND2 CCR1 FZD9 BMP4 PLA2G7 MMP7 PLD2 FZD2 CCND1 FZD7 SFRP1 AXIN2 ENC1 PLAUR MMP26 HEL-S-28 APC NOTUM LRP5 VEGFA CD44 LRP6 SHE TCF7L2 DVL3 WNT3 GIG8 TIMP1 GLI3 ADAM10 FRAT1 SKP2 PMC9313262__F3 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) INPPL1 PLAUR NPM1 DKK1 MAP2K3 COL1A1 CRK GRN AURKA CCDC80 CALM1 DCN VTN CCNB1 COL1A2 CNBP HEL-S-44 CCND1 HEL113 PMC9428246__F2 Propofol on macrophage activation and function in diseases STAT1 NLRP3 HMGB1 APOM TLR4 IL13 GSK3B SRC IL6 ABCA1 FOXA2 PMC4245043__F1 Model of the Fanconi functional pathway and protein components FAN1 BRCA2 FAP ATR PMC3478095__F2 Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease AGO1 AGO2 DGCR8 DICER1 AGO4 DROSHA PMC9428246__F4 Propofol on macrophage activation and function in diseases MRC1 TLR4 CXCL10 IL6 TNF ARG1 STAT3 PMC9313262__F6 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) STAT2 HMGCS1 IFNB1 HEL60 ADAM17 PTX3 STAT1 HLA-A APOL2 COL12A1 C7 HEL-S-44 FKBP9 SERPINB2 PMC4290619__F8 Signaling pathway of coagulation cascade for schizophrenia DRD3 F10 F8 F5 F9 F3 F7 F11 TFF3 DRD2 TF PMC10311035__F3 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders TSC2 TSC1 APC MLST8 PMC7378668__F7 Genes and processes involved in the 04662.B cell receptor signalling pathway BTK CD72 BCL10 BCR BASH CD22 LYN GRB2 SYK ELL CD81 CD19 PMC6614345__F3 Differentially expressed miRNAs in thyroid cancer tissues modulating the TGFB pathway SMAD2 TGFBR1 SMAD4 TGFB1 PMC8689584__F2 The major DNA damage repair pathways impaired in HPV-positive cancers RNF168 TRIP12 BRCA2 CCND1 RAD51 RB1 ATR PMC10311035__F2 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders APC SOST SMAD4 DKK1 DLL3 LATS1 LATS2 SUFU NF2 DLL4 SFRP1 SMO SMAD1 DKFZp781O1323 PMC11188434__F0 GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce the expression of type I interferon and pro-inflammatory cytokines CGAS IRF3 TNF PMC7378668__F6 Genes and processes involved in the 04660.T cell receptor signalling pathway DAO CD48 CTLA4 CBL ITK FYN BCL10 LCK ZAP70 GRB2 CDK4 LAT ICOS PMC7378668__F5 Genes and processes involved in the 04145.Phagosome pathway CD14 TLR4 MPO MARCO TUBB M6PR VAMP3 CD6 EEA1 STX18 HEL-S-99n RILP PMC6953314__F3 Intracellular signaling pathways of CAP, SNS, and HPA axis for anti-inflammatory responses FGF21 TLR7 TLR4 IRAK2 TRAF6 IRAK4 MYD88 STAT3 PMC9607206__F6 Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus TLR8 TLR7 IRF7 IRF8 TRAF3 TRAF6 IRF3 MYD88 TLR3 MAVS PMC8227550__F3 RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling TBK1 NLRP3 IRF7 IRF3 MAVS PMC6370374__F6 Molecular mechanism underlying LINC01133 regulated pancreatic cancer progression WNT1 GSK3B DKK1 EZH2 PMC6126176__F4 miRNA-risk genes-pathways regulation network ZMPSTE24 MARCKS F8 MEIS1 MANEA TMEM218 TACSTD2 MTSS1 ZEB2 BRWD1 ATG12 SAMD12 PSMA2 CAND1 ACBD3 SNRPC RAB21 LETMD1 CSRNP3 GABBR2 PCMTD2 SAMD13 PRR14L KRTAP2-4 ZKSCAN1 GHITM ZRANB2 SHISA2 PRKCE MAP2 NACC2 ACRV1 CTCF TEAD4 PTEN PPM1B PALMD MRC1 AGA ZNF257 RAB32 RGS8 KLF15 GNRHR TOX3 TNPO1 TMEM170A INTU ZNF17 LTA PMC6126176__F6 miRNA-core gene-risk signaling pathway regulation network JMJD1C TJP1 F2R APAF1 CDKN1B CAB39 BDNF AKT3 PMC5696061__F2 Rethinking HSF1 in stress, development and organismal health EDC4 IGF1 MTOR HSF1 FBXW7 SIRT1 PMC5595345__F8 Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage SMC3 CTCF RAD21 PMC6614345__F2 Differentially expressed miRNAs in thyroid cancer tissues modulating the PI3K pathway ST8SIA4 GRB2 PTEN MTOR PMC6224293__F1 Pathways involved in the synthesis of the main glycerolipids present in Arabidopsis mitochondrial membranes PC PGP PSD PMC9016027__F1 Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration OMG SEMA3A NRP1 ARHA LINGO1 PMC6614345__F1 Differentially expressed miRNAs in thyroid cancer tissues modulating the MAPK pathway BRAF ERBB2 EGFR GRB2 RAF1 SOS1 PMC9513225__F1 Implication of non-coding RNA-mediated ROCK1 regulation in various diseases MMP2 PTEN CDH2 HEL-S-36 PCNA STAT3 PMC11958968__F11 DSF against renal fibrosis via inhibition of PIK3/Akt/mTOR signaling pathway SMAD4 PTEN CDH2 MTOR PMC10311035__F1 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders APC LRP5 ARHA RYK PMC11513202__F2 Relationships between DNA methylation and hepatocellular carcinoma (HCC) proliferation, apoptosis and angiogenesis MDM2 CCND1 CDK4 CASP8 PMC5979509__F4 VEGFR2 signal transduction and trafficking pathways mediated by VEGF-A BAD SRC SHB PMC2742684__F1 Key signaling pathways between amino acids, inflammatory cytokines, and tumor-specific factors gr1Amino acids stimulate muscle protein synthesis through the mTOR pathway ELF2 EIF4E MTOR MYOD1 PMC5686903__F2 Over-expressed genes of Basal-like samples in p53 signaling pathway MYC PTEN RFWD2 TSC2 CASP3 SIAH1 PERP ATM CDK2 MDM2 CASP9 CDK4 ATR PMC6687952__F7 Pathway convergence of proteins encoded by both ASD DMRs BAD IGF1R GRB2 MTOR CYP2E1 PMC8573085__F1 Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease LPL NR1C1 CD36 PMC8258105__F1 Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease IL10 TLR9 CXCL10 CCL4 IL6 CCL2 TNF CARD9 SYK FCN1 ACE2 TMPRSS2 CCL3 PMC9278015__F4 Significance of interferon signaling based on mRNA-microRNA integration and plasma protein analyses in critically ill COVID-19 patients FITM2 PMC8961531__F3 Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson’s Disease ARC MTOR BDNF PDYN PMC11945619__F6 Principal component analysis (PCA) of growth and development indices and related genes in the liver tissue of Rana zhenhaiensis tadpoles after exposure to polypropylene (PP) and polystyrene (PS) GPX4 DGAT2 BAG6 ACHE ABCB11 HEL-S-104 PRDX3 BNIP2 HEL-S-2a HEL-S-67p ACACB PKLR IKBIP ACSF2 HSD17B4 SDHA SDHB PTGS2 IFNAR2 DEPTOR TRIM39 HEL-S-162eP IKBKB CASP3 APOB NR1C2 ZNRF2 FAM120C SLC39A9 ACLY PYCARD PIK3R2 PMC11551650__F3 MET oncogenic activation HGF TPR HLA-DRB1 HEL-S-61 CBL PMC11551650__F6 C-MET pathway relays downstream signals to activate multiple oncogenic events to promote cell proliferation, migration, protein synthesis, and antiapoptosis BAD HGF MDM2 GRB2 MTOR STAT3 PMC4750502__F5 Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism SQLE CRY1 EBP SC5D DHCR24 GCK PROX1 HSD17B7 TM7SF2 CYP51A1 CYP8B1 DHCR7 FDFT1 ELOVL5 NCOA1 FAXDC2 NPAS2 PMC11551650__F4 Hepatocyte growth factor/c-Met axis activates the Hedgehog pathway through downstream signaling HHIP KIF7 HGF SUFU GLI3 GRB2 CCND1 SMO MTOR STAT3 PMC4387238__F2 Signals for the lysosome: a control center for cellular clearance and energy metabolism TFEB FES DEPTOR NR1C1 RHEB MLST8 PMC11513202__F7 Pivotal role of DNA methyltransferase in DNA methylation and HCC progression PANX2 RASSF1 HGF MYOCD CDKL2 LHX9 EZH2 MTOR DNMT3B GATA4 PMC11513202__F4 Relationships between DNA methylation and sorafenib resistance in HCC NF2 HDAC11 BNIP3L HDAC2 MORC2 BNIP3 CYP1A2 STAT3 TET2 PMC11513202__F3 Relationships between DNA methylation and adhesion, invasion and metastasis of HCC MMP3 CDH15 PLG TIMP3 EGFR EMX1 PMC12113536__F1 Aberrant pathways induced by SMARCB1 deficiency and corresponding therapeutic targets MYC CDK4 ME3 MTOR AURKA CDK6 HMGCR PMC7464394__F3 Glutamatergic synapse pathway and expression levels of sea lice exposed to three drugs MAX ACD GLS PMC9561277__F8 APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus TOPBP1 ATRIP SSB ETAA1 ATR PMC12206236__F1 Defining quality of cancer is cell cycle dysregulation, which results in uncontrolled cell growth and tumor formation CDK2 CDK4 CDC2 CDK6 PMC3943797__F1 Coagulation, Protease Activated Receptors and Viral Myocarditis TLR3 TF PMC6923859__F4 Regulation of immune response as the most relevant pathway in the infested susceptible (S) skin SOCS3 LIF APOC2 APOC1 CCL2 RAC1 HRAS SERPINA3 TIMP1 GRB2 TYK2 JAK1 OSM STAT3 PMC8882872__F3 Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease IDO1 NAMPT AHR ACE2 TGFBI PMC3141633__F3 Genes identified in the TGF beta pathway FST FRK LTB IFNG HEL-S-69p PMC8410789__F8 Working model of Alpha-KG-induced pyroptosis GSDMC CASP8 HEL-S-32 PMC5073228__F2 Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping AMD1 MDH2 PMC5500651__F5 Schematic illustration for signaling pathways of skeletal muscle growth regulated by let-7b IGF2BP3 IGF2 GHR PMC6198234__F5 Proposed mechanisms by which PKM2‐mTORC1 regulatory pathways contribute to resistance in RCC cells RICTOR PTEN MTOR PMC2928803__F3 Gene Expression Model for the Preferential Galactose Uptake in Yeast Cells KY PC GAL PMC12113536__F2 Summary of the role of SMARCB1 deficiency as a driver of the hallmarks of cancer in RTs CXCL10 EGFR HAVCR2 PRF1 CLEC9A PMC7549391__F2 Metabolic Messengers: ceramides ADIPOR1 MFF ADIPOR2 CERS3 LASS1 CERS5 KDSR CERS2 CERS6 CD36 PMC6148804__F1 Pictorial representation of un-inhibited Avian avulavirus 1 (APMV-1)-induced type I interferon (IFN) response in waterfowl cells STAT2 IRF9 IRF3 TYK2 MAVS PMC5433957__F2 Mechanisms of GPC3 in acute lung injury GPC3 ATF2 PMC5433957__F1 Positive and negative effects of GPC3 on its two main signaling pathways STAT1 KIF7 GPC3 SUFU ATF2 GLI3 SMAD4 JUN PMC5362412__F9 Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression HEL-S-30 ACO2 OGDH HEL-S-162eP PMC9405053__F2 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases GSK3B HMOX1 PMC9405053__F1 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases NLRP3 ABCA1 GAL HSF1 TLR3 PMC6172959__F7 Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit TBK1 CGAS RICTOR IRF3 PMC2566927__F2 Essence of retrograde signaling in model organisms CDK2 MKS1 AAMP PMC6728679__F5 Sketch map of the Wnt5a/Ror2 signaling pathway in bone marrow stromal cells (BMSCs) that derives osteoclast precursor migration and differentiation CXCR4 ROR2 CXCL12 PMC6307990__F7 The proposed model is a graphical representation of the mechanism of interaction of IDO1 and IL6/STAT3/PD-L1 in EMT regulation in bladder tumor cells IDO1 IL6 STAT3 PMC6669485__F9 Summary diagram of signaling pathway of this study KEAP1 ATR BAX PMC2234434__F3 Genes involved in apoptotic pathways were altered in type II cells isolated from Stat3Δ/Δ mice NTF3 BAD CFD CAST ATF2 APP CHAD TPR PTEN SAT2 CRK PMC7084654__F6 Hypothetical alterations of the metabolic pathways for ATP production in low-oxygen stress response PDC TNR PMC4160991__F1 Schematic diagrams of DA dynamics and signaling in (A) Drosophila cuticle, (B) Drosophila brain, and (C) mammalian brain TH DDC AANAT PMC7248557__F1 TLR4 Signaling pathway TLR4 IRAK2 TRAF3 LBP TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC154144__F2 Canonic Wnt signaling pathway molecules can induce a similar phenotype APC WNT10B PMC6026738__F7 Hypothesis model CXCL13 CXCR5 LTBR BCL6 PMC9380290__F1 Mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets ATM APC LRP5 BCL2 PTEN MTOR BAX PMC12138372__F2 Cellular mechanisms of hormones and their effect on bone maintenance ALPL RUNX2 BMP2 NFATC1 SOST BCL2 PMC4954455__F6 Working model of the molecular mechanisms of HDACi (e.g., abexinostat) on human skeletal (mesenchymal) stem cell differentiation into adipocytes and osteoblasts ALPL KLF15 VCAM1 MSC CEBPA COL1A1 PMC5341237__F1 Diagram showing key components of the IL‐6 signal transduction pathway that could account for lipogenic gene expression in hepatocytes SOCS3 STAT3 PMC6027159__F7 TNF-R1 signaling pathway TRADD CYLD SHARPIN TNF MAP3K7IP1 OTULIN TRAF2 ITCH TAB3 PMC8605459__F1 Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence TH AHRR AHR IL6 KLF6 CYP1A2 PMC6027159__F9 Nod1/2 signaling pathway SHARPIN RIPK2 MAP3K7IP1 NOD2 TAB3 PMC3488630__F2 Proposed model of HER2/3 signaling in epithelial cells NRG1 IL1B ADAM17 PMC6027159__F8 IL-1BR1 signaling pathway IRAK1 SHARPIN TRAF6 MYD88 MAP3K7IP1 IL1B TIRAP TAB3 PMC8016646__F2 Promotion, composition and intracellular activation of the VEGF‐VEGFR signalling pathway VEGFC BAD FYN VEGFD VEGFA SRC SHB MTOR VEGFB PMC8538279__F5 Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment BDNF STAT3 PMC8016646__F1 FGF‐FGFR signalling pathway FGFRL1 FRS2 GRB2 MTOR PMC12106324__F5 Canonical TGFB signaling via Smad signaling pathway SMURF2 SMAD6 SMAD4 SMURF1 PMC4382841__F5 Proposed model of novel roles of AQP3 and AQP5 in tumor biology AQP3 EGFR CCND1 SRC MTOR PMC4382841__F4 Proposed model of novel role of AQP1 in tumor biology AQP1 EGFR ARHA PMC2682028__F9 Changes in metabolism in Prx1-Cre; PORlox/lox limb bud cells and levels of cholesterol MVD FDPS ACLY ACAT2 PMC3881294__F2 Regulating intestinal function to reduce atherogenic lipoproteins DGAT1 PC DGAT2 MGAT3 LPA MGAT1 MGAT2 PMC9774615__F1 Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes COQ8A FDX1 COQ10B FDX2 COQ10A IPP COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PDSS1 COQ7 FDXR PMC2248159__F2 A part of the yeast cell cycle pathway available from KEGG [26] CDC20 FAR1 CDC6 GML CLN3 CHN1 PMC3010754__F2 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors CYP2B6 CYP3A4 PMC12095689__F4 Cotadutide enhances hepatic insulin-stimulated signaling pathways in DIO mice PPP1R3G LARP1 PTEN DEPTOR IRS1 INSR MLST8 TSC2 GYS2 TSC1 GRB2 RPS6 PYGL CP PMC7937695__F1 Three kinds of inflammasome pathways associated with pyroptosis FADD GSDMD DFNA5 PMC9423707__F2 Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future BAD TMEM43 EGFR IGFBP2 LATS2 STAT3 PMC5260888__F7 Role of RIPK1 in ConA hepatitis model RIPK1 TRADD TRAF2 PMC7937695__F2 Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease TLR4 TXNIP SIRT1 GSDMD PMC4112623__F2 Cancer related pathways and processes that input into the Hippo pathway NF2 SHH LATS1 MTOR PMC4112623__F1 The core Hippo signaling pathway in Drosophila and humans TEAD3 NF2 TEAD4 LATS1 MOB1A MOBKL1A LATS2 TEAD2 PMC5659038__F5 Relationship between lipids and hedgehog signaling GPR161 SHH SMO CAMKK2 PMC9598289__F13 Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H2O2-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway MAF FYN KEAP1 GSK3B MTOR STAT3 PMC2405801__F2 Description of possible involved signalling pathways EGF ATF2 EGFR GRB2 RAC1 CDC42 PMC6008986__F1 Kynurenic acid (KA) is the product of kynurenine pathway, the central metabolite of the tryptophan metabolism KYAT3 OPN3 KYNU KMO PMC8013977__F6 IL-15–PI3K–AKT-mTOR signaling for NK cell development TSC1 PTEN FOXO1 GATA3 PMC8013977__F5 IL-15-JAK-STAT5 signaling for NK cell development SOCS2 SOCS3 VEGFA JAK3 PMC7248557__F4 Alteration of TLR4 signaling in pregnancy disorders TLR4 TRAF3 IRF3 MYD88 PMC10897999__F1 Roles of circRNAs involving interaction with RBPs or other proteins in GC NOTCH4 EIF4EBP3 GPX1 CD44 MAP4K1 SLC7A5 AGO2 HNF4A IGF2BP3 SLC2A4 NOTCH1 CNBP PCBP1 PMC6970631__F1 Key CSC signalling pathways Notch, Wnt, and Hedgehog DLL4 APC GSK3B DLL3 PMC10897999__F3 CircRNAs work as translational templates to contribute to the proliferation and progression of GC HEL-S-2a SET APC PARP1 MAPK1 MTOR RBX1 PMC6970631__F3 Key CSC signalling pathways TGFB, JAK/STAT3, and NfKB ADA STAT3 ADK PMC6923785__F1 Mechanisms of resistance to PI3K inhibitors in estrogen receptor (ER)-positive breast cancer and current and future drug combination strategies involving PI3K inhibitors EGFR CDK4 PTEN MTOR CDK6 PMC3980897__F1 Dual-view setup of the enRoute visualization technique SOST EGFR NRAS GRB2 HRAS ARAF PMC3285457__F6 Smad7 is Inactivated through a Direct Physical Interaction with the LIM Protein Hic-5/ARA55 SMAD2 PMC2247392__F2 Growth factors trigger local and long distance signalling NGF EGFR MAPK3 BAP1 PMC6190593__F2 Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology ATF2 MYD88 GAA FADD PMC7553635__F6 Activating Wnt and inhibiting Hippo pathway by cytosolic PWP1 MMP7 CCND1 DVL2 LATS1 PWP1 TCF4 PMC3659569__F2 Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies CRTC2 FOXO1 PMC6446989__F2 Biliary tract cancers: current knowledge, clinical candidates and future challenges NOTCH2 INA EGF NOTCH4 BRAF OMP EGFR APC ERAS MTOR NOTCH3 FGFR2 TET2 NOTCH1 PMC9099918__F1 Novel Therapeutic Approaches with DNA Damage Response Inhibitors for Melanoma Treatment WEE1 ATM CDK2 ATRIP SSB CDC2 ATR H2AX PMC6826129__F7 Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) as a central mediator of vascular aging TGFBR1 NOX4 CEACAM1 PMC6015651__F1 Domains and functions of MCPyV T antigens RFC1 TLR9 MAX MYCL MYC EIF4E PMC2976970__F3 Protein-protein interaction map of Notch transcription modifiers MYB TTK RPL6 RPS9 CDK8 RPL19 MED17 RPS17 HEPH DMAP1 UPF2 SMG1 SIN3A CDK9 PMC4875723__F6 Systematic model of the Hippo/YAP signaling pathway affecting cytotoxic drug resistance in osteosarcoma cells LATS1 LATS2 PMC12141490__F9 Neural controlled tear secretion from lacrimal gland NTS LPO ADRA1A UCP2 PMC9640682__F4 MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosis HGF IGF1 HEL-S-28 SMAD2 GRB2 SMAD4 TRAF6 CDH2 STAT3 PMC5803335__F3 Cytoplasmic APC and the WNT signaling pathway APC GSK3B GPR49 PMC10987773__F5 Hepatic protein and amino acid metabolic pathway during pregnancy RPS6KB1 NFE2L2 PMC7972934__F7 Mechanistic illumination of the inhibitory role of VB in GBMVB promotes the expression of miR-7-5p in GBM cells and facilitates the delivery of miR-7-5p by exosomes to recipient GBM cells MMP9 EGFR CDH2 PCNA BAX PMC10987773__F4 Hepatic lipid metabolic pathway during pregnancy APOB ANGPTL4 TG NR1C1 CYP7A1 INSR PMC10987773__F3 Hepatic glucose metabolic pathway during pregnancy ANGPTL4 SLC2A4 SLC2A2 IRS1 INSR PMC4288710__F7 Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms CD14 LCP2 PLAUR CXCR4 PXK PMC8799556__F6 Integrin-linked kinase (ILK): the known vs. the unknown and perspectives RICTOR ILKAP HEL-S-28 RAC1 CDC42 PMC11899901__F4 KEGG pathway map showing the differentially spliced genes within the adrenergic signaling pathway in the heart PLN TNC MYL2 HEL-S-273 ADCY6 GNAS SCN1B CACNA2D1 RYR2 CACNA1C PMC8064971__F2 Targeting protein-protein interaction interfaces in COVID-19 drug discovery FURIN ACE2 TMPRSS2 HEL-S-69p PMC11903262__F2 Protective role of Trem2 in different models of myocardial injury IL10 SYK PMC3010754__F1 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors CYP2B6 CYP2C9 CYP2A6 CYP1A2 PMC8562402__F1 Therapeutic effect of oxygen-ozone in controlling of COVID-19 disease NLRP3 KEAP1 CRP PMC8750298__F3 Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications RECK LRP5 LRP6 PMC9319012__F11 RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection PGM3 RELA GNPNAT1 OGG1 GFPT1 PMC4546481__F4 Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth STAT1 COL6A1 PMC5729307__F2 Pathway signalling starts with the binding of insulin or growth factors to insulin receptors PTEN RHEB PMC8037405__F2 Key regulators and genetic pathways of phase transition from SAM to IM in cereal crops EHD1 EHD2 ID1 PMC9075957__F3 Interacting genes form a diet-responsive network affecting adipogenesis F2R EBP HEL-S-111 SRGN TNFRSF11A CDKN1C NNAT HMGCR PMC4685486__F3 Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases NLRP3 TLR9 AIM2 IL1B PMC8635032__F1 Recent Progress of Ferroptosis in Lung Diseases GPX4 LPCAT3 FACL4 FTH1 NQO1 STAT3 BAP1 PMC8706767__F2 NF‐KB signaling in inflammation and cancer TBK1 TRADD OTUD7B IRAK1 RELB TRAF3 TRAF6 IRAK4 MYD88 BCL10 CYLD TRAF2 TAB3 PMC3901146__F1 Regulation of cellular stress-induced cell death pathways by IAPs CASP3 NAIP CASP9 SMS FADD PMC3901146__F3 Role of IAPs in DNA damage response ATM MDM2 TRAF6 FADD PMC7438569__F5 Cardioprotection from NAD+ repletion NAMPT SIRT7 PARP1 SIRT1 GATA4 PMC7438569__F1 NAD+ metabolism in the heart NAMPT NMNAT1 NMNAT2 NMNAT3 PMC2861866__F3 Hypothetical model linking multiple biological pathways in the development of SS-like disease based on differentially expressed genes identified in lacrimal glands by global microarray analyses STAT1 CTSS COL1A2 APOD CTSH RAF1 CXCL12 B2M APOE STAT3 PMC3328908__F10 Diagram of canonical actin cytoskeleton signaling pathway EGF APC DAP CRK PMC5753157__F1 T-helper responses to A TH AHR IL33 CTLA4 GATA3 IFNG STAT3 PMC3497295__F1 Selected signaling pathways in renal cell carcinoma (RCC) EGF EPO APAF1 VHL RHEB PMC6384818__F6 NOD1 and TLR4 signaling pathways and the main target of CBN in the suppression of LPS-induced inflammation CXCL1 TLR4 NOD1 MYD88 IL1B PMC10373067__F2 Bispecific antibody targeting TGFB and PD-L1 for synergistic cancer immunotherapy SMAD2 TGFBR1 TGFBR2 SMAD4 FURIN TGFBR3 PMC12125911__F7 Schematic diagram of VWA1 and Rac2’s roles in condylar cartilage under mechanical stress ADAMTS5 VWA1 FGFR3 BCL2 ACAN FGF9 PMC3296807__F1 Oncogenes and tumor suppressors associated with the regulation of autophagy TSC2 BAD TSC1 PTEN BNIP3 MTOR RHEB MLST8 BAX PMC6335350__F2 Therapeutic approaches in Alzheimer's disease: GSK3 Inactivation therapy: Neuroprotective compounds such as curcumin modulates PI3K/Akt/GSK3B pathway, leading to inactivation of tau hyperphosphorylation MTOR SIRT1 PMC6028070__F1 Cytokine signaling and their major negative regulators TRADD JAK1 TNF TRAF2 FADD PMC6335350__F1 Interplay between mTOR, AB and Tau in Alzheimer's disease TSC2 TSC1 CDK5 EIF4E MTOR IRS1 RHEB PMC4463992__F3 Most possible acting pathway of p42.3 protein by optimization of Bayes theorem CENPB S100A2 VHL RHO HEL-S-43 PMC7969667__F10 Schematic model of RipA depicting possible interaction of RipA with surface immune receptor TLR4 and emanating downstream cascades TH TLR4 MDM2 TRAF6 TNF SDHA TIRAP PMC7662708__F5 Kynurenine Induces Osteoclastogenesis Via the AhR Signaling Pathway AHR CYP1B1 NFATC1 PMC7170981__F5 Evaluation of genes regulated by butyrate in controls and patients with UC CCR5 HLA-E TLR9 CXCL8 TRAF6 CCL5 IL1R1 CCL2 MAP2K3 TICAM1 FOXP3 NLRP3 STAT1 RIPK1 IL18 BIRC3 IL2 CD40LG CSF2 RORC IL10 TLR5 IL1A CXCL10 IRF3 IL6 IKBKB NFKB1 RELA TNFRSF1A PIK3CA CD80 TIRAP PMC8280132__F3 System biology approach based on metabolic biomarkers and protein–protein interactions for identifying pathways underlying schizophrenia and bipolar disorder PIG59 ABAT HEL-S-8a GAD1 GLUD1 GFPT1 GLS PMC4463992__F2 Primary regulatory networks CENPB S100A2 VHL RHO SP1 HEL-S-43 PMC5474285__F1 Workflow: network analysis, relevant organ location network analysis, gene ontology, and pathway analysis were performed on active compounds identified in Pulsatillae Radix (PR) by screening and target fishing BAD APC LPA MPL BAX PMC5474285__F5 Network pathway: pathway enrichment analysis was performed TLR4 APC NOD2 STAT3 PMC7814589__F6 Signaling pathways regulating short stature in the Debao pony IHH TRPV4 SOX2 MMP25 MMP9 MYD88 SOX9 INSR GHRH ALPL PLCB2 IGF1 TSHR TNFSF14 SOX11 TRH COL9A2 GHR SOX5 COL2A1 COL9A1 PMC8066113__F2 Interactions between proteins, cells, and lentiviral infection for the GIMAP2 gene in PBNCs, as analyzed by the Pathway Studio program IL7 GIMAP7 IL7R GIMAP2 PMC7535138__F2 Intracellular signal transduction of adipokines and insulin resistance SOCS3 LEPR IRS1 STAT3 PMC4129373__F1 Schematic cartoon of TLR signaling pathways TBK1 CD14 TLR5 TLR9 IRF7 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR10 TLR3 TLR8 TLR7 TLR4 LBP MAL CD36 PMC9029125__F2 Impact of Treadmill Interval Running on the Appearance of Zinc Finger Protein FHL2 in Bone Marrow Cells in a Rat Model: A Pilot Study RUNX2 FHL2 SRC SP1 KLF8 PMC4900422__F1 Constitutive CBM signaling in B- and T-cell malignancies LIMA1 BCL10 BCR CD79B CD79A ICOS PMC7744297__F2 AChR clustering and dispersal pathways MUSK LRP4 CDK5 CRK CRKL PMC7744297__F4 Simplified representation of the AChR pentamer and the N-glycosylation pathway of proteins and CMS-related genes (red color) ALG11 DPAGT1 ALG13 ALG5 DOLK GFPT1 DPM2 DPM3 RFT1 DPM1 ALG2 ALG3 ALG12 ALG6 ALG10 GMPPB PMC6960179__F5 Molecular evidence of inflammatory response and resolution of inflammation during MAP infection TNLG1B TNIP2 NLRC4 SOCS3 TRADD IRAK2 TRAF6 NOD2 TLR4 PDGFA TRAF1 KLF4 NOS2 IRAK3 TRAF2 STAT3 PMC8836182__F1 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC TSC2 BAD TSC1 IGF1R EGFR PTEN ABCG2 PMC3748035__F1 Dynamic regulation of P2X4 receptors in microglia BDNF IFNG PMC7242206__F2 Possible targets of the androgen pathway for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylaxis and adjuvant therapy ACE2 TMPRSS2 PMC8836182__F2 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC LEF1 TCF4 PMC2641000__F4 Cell-Autonomous Requirement for Rx Function in the Mammalian Retina and Posterior Pituitary SOX2 SIX3 OTX2 ZIC2 PMC8303665__F2 Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma EGFR GRB2 SRC PTEN PMC10178469__F2 Downstream signaling pathway of TLRs TLR8 TLR7 TLR4 TLR9 MYD88 TLR3 MAL PMC11754255__F2 Primary role process of CCL2 in fibrotic diseases CCL21 CCL2 TNF ACE2 NOTCH3 ACKR2 PMC5952217__F2 Kynurenine pathway is initiated by the oxidation of tryptophan via the enzymes IDO and TDO, with downstream catabolites having toxic, antioxidant and cell-protective activity AHR KMO HEL-S-92n IL6 IFNG PMC11754255__F1 CCL2/CCR2 axis and its associated signaling pathways CCR2 CCL2 MTOR STAT3 PMC5952217__F1 A schematic illustrating some of the factors proposed to affect obesity and carcinogenesis AHR IL6 MTOR IL1B IFNG STAT3 PMC6269289__F1 A simplified diagram of sialic acid metabolism in human GNE CMAS SLC35A1 NANS SLC17A5 NANP PMC2741489__F5 Known components of the IFN signalling pathway and explanation of observed results HEL-S-11 ISX PMC6446705__F2 Pathways modulating NAD+ levels in mammals NAPRT NNMT PARP1 NRK PMC4546458__F7 CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms CXCL16 ARHA CXCR6 PMC2220082__F2 Rosilitazone stimulates NSCLC proliferation by affecting the Akt/mTOR pathway through PPARGamma-dependent and PPARGamma-independent mechanisms TSC2 PTEN MTOR PMC2153436__F4 Immune Response and Cell Cycle Networks CCNA2 PLK1 BIRC5 CENPF TRAF6 PRC1 ECT2 NF2 SRC RAD51 C1S MKI67 PSMB8 TNFSF8 PLG MASP1 TACC3 CTLA4 UHRF1 TNF NR1C1 BRCA1 SPAG5 C8A CDC20 SPI1 CCNB2 NEK2 SAA2 PMC11667047__F1 Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions ABCB6 FECH UROD SLC25A38 UROS ABCB10 CPO PMC4844852__F1 Environmental Exposures – The Missing Link in Immune Responses After Transplantation AHR CYP1B1 CYP1A1 CYP1A2 TF PMC11667047__F2 Molecular mechanisms underlying the physiological and pharmacological effects of 5-ALA (in the presence of Fe2+)The green line indicates positive regulation, the red line indicates inhibition, the dashed line represents indirect effects BCR UCP1 KEAP1 IRS1 UCP2 PMC8067556__F1 WW domain-containing oxidoreductase (WWOX) interaction partners and signaling pathways in the nervous system SMAD2 APC SMAD4 WWOX PMC5837599__F3 Typical structure and content of exosomes CD9 CD63 CD81 PMC11106351__F9 Anti-hepatitis B virus mechanism of dopamine STAT1 ISG15 DRD1 LHB PMC4825016__F7 Proposed model for cross-talk of IGF1 and integrin signaling IGF1R IGF1 SRC PMC5099148__F1 Biosynthetic pathway of pharmaceutical terpenoids AACS MVK CR1L PMC2775047__F1 TLR Mediated Immune Responses in the Urinary Tract CD14 TRAF6 MYD88 TIRAP MAL PMC7392886__F2 Development of immunothrombosis.Platelets activated by thrombin and or PICs initiate (PAR)–mediated signalling further increasing levels of PICs VWF and TF coupled with suppression of suppression of thrombomodulin TFPI PLG VTN TF PMC5028879__F1 NOD2 senses MDP and elicits immune responses ATG16L1 TRAF6 RIPK2 NOD2 PMC6530647__F4 Carbon monoxide controls metabolic homeostasis via the PERK-eIF2Alpha-ATF4-FGF21, SENS2, and REDD1 pathway FGF21 ATF4 EIF2A SESN2 PMC7759159__F1 NFKB activation is central to the acute respiratory RNA virus-induced cytokine storm TLR8 BTK TLR7 TLR4 TRADD IRF7 VCAM1 IRAK4 MYD88 ACE2 TLR3 TMPRSS2 PMC4782048__F7 Model depicting how AMPK regulates cell fate decisions through lysosome-dependent control of Wnt signaling TFEB GSK3B MTOR SOX17 PMC9366225__F1 CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction ADAM10 MTOR CXCR6 PMC8507548__F1 Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis NLRP3 TLR4 CXCL5 IL8RB STAT3 PMC5809980__F4 Diagram illustrates the dominating signaling pathways involving Sal- induced autophagy TSC2 TSC1 TRIB3 MTOR DEPTOR RHEB PMC5596442__F2 Two strategies for photoactivation of cell signaling pathways PI3 CRY2 PMC4661823__F3 ER stress sensors and Programmed Cell Death in animals ATF4 EIF2A TRAF2 PMC9365022__F5 Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation PERP ATM LIPI SHE GLA PMC4899745__F1 Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase BDH1 GPD2 HEL-S-4 GPD1 PMC6237873__F5 LncRNA-mRNA interaction networks BMP7 RHO JUN PMC8231864__F1 Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles PTEN PMC5564566__F6 Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC) EGF JAK1 NOTCH3 HES1 PMC9266941__F1 Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification BMP2 SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC5495797__F7 Differences and commonalities in TLR4- and FcERI-activated production of proinflammatory cytokines TLR4 BCL10 TRAF6 MYD88 TNF LAT TAB3 MAL PMC5722026__F1 PCP and SHH Signaling pathways KIF7 SUFU SMO PMC1698511__F3 PKR is an intermediary component in TLR signaling IRF7 TRAF6 RIGI IRF3 MYD88 TIRAP TAB3 PMC7699852__F1 Simplified representation of aryl hydrocarbon receptor (AhR) pathways AHR CYP1A1 PAH PMC9076607__F2 OPG-related signaling pathways TRAF5 NFATC1 GSK3B TRAF3 VWF TRAF6 TRAF2 PMC5329766__F2 Understanding the intersections between metabolism and cancer biology PC FH DHODH GLS PMC7699852__F4 Deleterious effects of aryl hydrocarbon receptor (AhR) activation in asthma AHR CXCL8 TSLP PMC10975298__F4 Signaling pathways against resistant cancer BAD KIF7 MMP9 EGFR GIP PTEN MTOR MMP2 SUFU CDK2 NOTCH1 SMO BAX PMC5797591__F1 Schematic overview of the roles of the Notch pathway in CD8+ T cells and its application to immunotherapy DTX1 IFNG HES1 PMC5380330__F4 MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells TNFSF6 TNFSF10 PRF1 CSA2 TNF OSM LAT PMC3665230__F6 Pathway members of insulin/Akt signalling, TGFB, wnt signalling and inflammatory pathways that were regulated by prednisolone in 3T3-L1 cells EGR1 CXCL5 CXCL10 CCL7 FZD4 PTEN IL6 DKK2 FZD1 FZD5 LEF1 GREM1 GIG8 FZD2 MCL1 PMC10975298__F1 Mechanisms of drug resistance in cancer cells PGP PTEN BAX PMC7286536__F1 Insulin regulates glycolysis through both AKT-dependent and AKT-independent mechanisms BAD TXNIP PTEN HK2 HEL-S-162eP PMC9218457__F6 Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1 IL22RA1 MSC GSK3B DMBT1 STAT3 PMC5541666__F1 Details from the STRING interaction diagrams within the global transcriptome profiles of Pink1-deficient mouse cerebellar tissue EXO5 POLD2 MAPK9 GSKIP MAPK8 HEL-S-1 LGI2 MAPK14 KPNA1 SNX16 NCK1 CCNE1 GPSM1 LIMA1 STAT1 POLE4 CYLD POLE3 FZD2 MAPK1 PTPRT FKRP ISY1 AHI-1 IRF3 KCTD15 PIK3R3 ADCY3 CREB3 YTHDC1 TRA2A SEMA5A PCF11 MMP14 SEMA6D SLCO3A1 SVOP SLC45A4 AKT3 CLMN ARHGEF39 IKBKG CHUK CPSF6 MAP2K4 AGK RAB3GAP2 FZD1 RAC1 TRABD SRSF10 NFKBIA ZFAND5 RNF128 PMC2946555__F2 Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival LATS1 PMC6476910__F2 DAMPs exposure ROCK1 ATF4 EIF2A PANX1 DKFZp686F0183 SNAP23 BAX PMC8905584__F10 To detect potential pathways and target genes in infantile Pompe patients using computational analysis FER APC STRC STX3A PXN CBL PMC7913036__F1 Iron cycle in the tumor microenvironment (TME) CD163 LCN2 IL1B TF CP STAT3 PMC3276621__F2 Pathways for the synthesis of glycerolipids and their subcellular localization PGS1 PI3 CDS1 PC GPT2 PGP INS PSD2 FAT1 PMC12108002__F2 Major signaling pathways and transcription factors in BMSCs RUNX2 BMP2 GC SKI PMC5405066__F7 Hypothetical mechanism of action of BoNT/A is achieved through the modulation of TLR2 and SNARE proteins, and minocycline occurs through the modulation of p38 and MMP9 in glial cells IL10 IL16 TLR4 IL6 IL18BP PMC3391329__F3 Proteome coverage of the KEGG ‘Insulin Signaling’ pathway TSC2 BAD GRB2 INS EIF4E MTOR POC1A FOXO1 RHEB CR1L INSR CBL PMC11977922__F1 Signaling mechanism of the canonical cGAS-STING pathway and its downstream effects in diseases TBK1 CGAS IRF3 PMC11977922__F2 Mechanisms by which lipid metabolism regulates the STING signalling pathway CGAS SMPDL3A PMC3180192__F2 TGFB pathway genes in iMYC cells BAMBI MGP CTDSPL TGFBR1 TNFRSF11B COL1A1 SERPINE2 HTRA1 RHOD DCN ZFP36 COL12A1 ROR2 TGFBR3 SMAD1 INHBA COL4A2 STAT3 PMC11977922__F4 Mechanism through which STING activation leads to insulin resistance TBK1 AIG1 JMJD8 IRF3 PPP2R1B TNF IRS1 PMC7174681__F3 Effects of mTOR inhibition are shown CDK4 PTEN EIF4E DEPTOR IRS1 CDK6 PMC7174681__F2 Dashed lines indicate a decreased interaction between two components or a diminished function CDK4 PTEN EIF4E DEPTOR IRS1 CDK6 PMC5137585__F2 Diabetic cardiomyopathy: signaling defects and therapeutic approaches PTEN MTOR IRS1 PMC7174681__F1 ER, mTOR, and CDK4/6 pathways and their links are shown CDK4 PTEN EIF4E DEPTOR IRS1 CDK6 MLST8 PMC7797765__F1 Simplified overview of the complement pathway HEL-S-62p C7 C6 PMC3141028__F4 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation CIT ELL PMC10743075__F10 n-3-PUFA administration decreased mRNA expression of pro-inflammatory cytokines, as documented in the TNF signaling pathway TRADD FOS LIF TRAF3 TNF TRAIP NOD2 IL15 CASP3 FADD MLKL SELE TF ALPI PMC3909817__F4 Potential mechanisms of TGF-Beta-induced upregulation of Nox4 gene expression SMAD2 NOX4 PMC7943311__F6 Signaling pathways critical for the roles and differentiation of Th9 cells and Treg cells in solid tumor IL7 CD40 HIF1A MTOR FOXO1 FOXP3 PMC5325806__F2 Intersections of Post-Transcriptional Gene Regulatory Mechanisms with Intermediary Metabolism CIRBP SFRS3 SIRT1 FOXO1 PMC9482322__F7 Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma SCD ANXA2 ACSS2 MTOR TF FASN PMC7452942__F2 Soluble protein sensors built by means of bottom-up approaches FGFR1 TF PMC4999974__F7 PAC-1 enhances the apoptotic signal as induced by cytotoxins such as doxorubicin HEL-S-62p CAD BAX PMC7601316__F1 Tumor necrosis factorA (TNFA) downstream signaling pathway mediated by two TNFA receptors, TNFR1 and TNFR2, and by membrane form of TNFA (mTNFA) reverse signaling TRADD TRAF3 TRAF2 PMC3701226__F2 Signaling pathways triggered by TCR and CD28 engagement PLCG1 TSC1 BCL10 RAF1 EIF4E PMC5541666__F3 Systematic analysis of key factors in the mitochondria-associated innate immunity pathway, using acute starvation of human SH-SY5Y neuroblastoma cells to reveal the transcriptional regulation of stress responses and their dependence on PINK1 MFN1 IFIT3 PINK1 IFIT2 RSAD2 TRADD IRF7 IRF3 MAVS IFIT1 PMC8825370__F4 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer NF1 GRB2 ARHA MTOR PMC8825370__F3 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer ELF2 BAD MEI1 TRADD TRAF2 FADD BAX PMC7433817__F6 Schematic chart of drug sensitivity‐related genes in the current study with proposed interaction or regulatory pathway in ccRCC LRP10 RET CTBP1 MDM2 GNAS ACRBP MTOR AXL CCNE1 PMC8304139__F3 NFKB—An Important Player in Xenoestrogen Signaling in Immune Cells BCL10 BCR LTB RELB SYK PMC7118125__F3 Signaling networks in immunometabolism ULK1 MFF FLCN FNIP2 FNIP1 CAMKK2 PMC11126125__F4 Immune response induced by DTMUV infection and its immune evasion TBK1 TRIM32 TRIM56 IRF3 MAVS PMC3185015__F9 RSPO1/Beta-Catenin Signaling Pathway Regulates Oogonia Differentiation and Entry into Meiosis in the Mouse Fetal Ovary RSPO1 NANOS2 FGF9 PMC8369065__F1 Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection TLR4 APC PMC2699853__F1 Diabetes alters the expression of multiple genes of the TGFB pathway (left side of the panel) and BMPs pathway (right side) in rat retinal vessels ELK3 COX1 TIMP1 BMPR1A HOXC8 TGFBR1 CD44 NOTCH1 SOAT1 IFNGR2 TXNIP MXI1 PMC4643662__F2B Proposed signaling mechanisms of S100A8/A9 in pancreatic-cancer cells.S100A8/A9 could interact with RAGE, leading to the activation of MAP kinases and NF̃KB signaling TLR4 S100A8 S100A9 MTOR PMC4692127__F8 Downregulation of the Canonical WNT Signaling Pathway by TGFB1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics IGF1 DKK1 WNT2B WNT5B PMC5220431__F4 The HH signaling pathway in lung cancer PRKCI SOX2 GRPR SMO PMC5220431__F2 HH signaling pathway during development BOC SUFU GLI3 SMO PMC8825370__F1 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer EGF TLR4 BCL2 MTOR PMC3306451__F2 Integration of mitochondrial oxidative and antioxidant pathways by PGC-1A NR1C1 SIRT1 SIRT3 PMC8032984__F2 B7-H3 increases ROS and HIF-1A through B7-H3-induced Nrf2 suppression, SOD1, SOD2, and PRX3 reduction, thus promote aerobic glycolysis in cancer cells, leading to tumor growth APC HEL-S-44 MTOR TGFB1 PMC8536186__F6 Fractionated Seminal Plasma of Boar Ejaculates Analyzed by LC–MS/MS: Its Effects on Post-Thaw Semen Quality MAPKAPK2 DMWD ALB NUP214 SEC23A CD74 AAAS CRK ST13 CSTA ATM APP GNAL NUP107 MEF2C PMC2818238__F1 Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms PC CA4 PMC7226273__F5 Proposed mechanism for Vinorelbine’s radio sensitizing effect ATM ATR PMC8051751__F6 Molecular mechanisms induced by sirt1 inhibition in ACC cells IGF1R CCND1 CDH2 BAX PMC7774512__F3 Working hypothesis of Glial Molecular Mechanisms Implicated in the Pathogenesis of POI IL16 S100B IL1B NR1C1 PMC8063300__F1 Aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications AIP AHR RELA RELB CYP1A1 CSA2 NQO1 PMC11687167__F4 Signaling pathways associated with PCSK9 during the immune response (created in https://BioRender TH STAT1 PCSK9 TLR4 NFATC1 STAT4 STAT3 BAX PMC7926563__F2 Therapeutic agents targeting the B-cell receptor (BCR) signaling pathway in follicular lymphoma BCR LYN SYK PMC9020237__F1 Emerging role of the itaconate-mediated rescue of cellular metabolic stress SUCNR1 ATF3 IL1B PMC8306340__F5 Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC TH IKBKE IKBKG CHUK PSMD9 TRAF3 PSMD7 COX2 IL18 CYLD PSME4 RASSF2 PHB2 PSMA4 MAP3K7 TNLG7C IKBKB EDAR LTA EP300 NFKB2 VCAM1 NFKB1 RELA HEL-S-276 MAP3K14 LITAF SPHK1 RPS3 TRAF2 PMC9006990__F2 Anti-EGFR Monoclonal Antibody in mCRC Maintenance Therapy EGF EGFR PTEN MTOR PMC1828869__F2 Regulation of induction and vesicle nucleation TSC2 TSC1 PTEN ATG14 RHEB PMC3889251__F9 New proposed model of BMP2-induced C2C12 cells differentiation BMP2 SMAD4 MTOR PMC9701395__F9 Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix COX2 BAD CASP9 SRC CDC42 PMC5864196__F3 Potential metabolic capabilities CIT OTP MAL PMC2663056__F4 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling CASP3 EGF MAX TNF CASP8 IRS1 PMC3889251__F1 BMP2 signaling pathway resulting in osteogenesis or adipogenesis BMPR1A BMP2 ATF2 MAP3K7IP1 TF PMC4089092__F1 Toll-like receptor (TLR) signaling pathway CD14 TLR4 TRAF6 MYD88 PMC7521272__F4 Pathway analysis of the differentially expressed proteins between the gastric cancer (T) and adjacent tissues (P) NDN UQCRFS1 NDUFA12 SI COX10 NDUFA11 SDHD SDHA SDHB UQCRQ SDHC NDUFS6 NDUFB9 NDUFA6 NDUFAB1 NDUFS3 CYB UQCRC2 NDUFC2 ND6 COX17 UQCRH NDUFA3 NDUFB7 NDUFA10 ND4 PMC10239510__F7 Paradigm summarizing the thermogenic and anti-inflammatory properties of YJT via the gut microbiota and related multiple signaling pathways PGLYRP2 TH PRDM16 TRPV3 NOD2 TRPV1 TLR4 FFAR3 DIO1 PGLYRP1 FFAR2 CIDEA ADRB3 PCNA GPR65 PMC2663056__F3 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling EGF TNF CASP8 PMC4821196__F2 Summary of the intracellular signaling cascades that occur within neurons and glia within the brain VIT SST GSK3B MTOR BDNF JUN BAX PMC9322149__F4 Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models CELA1 TRADD HEL-S-11 LIF TNF TNLG7C TRAF2 FADD SELE ITCH PMC3758473__F5 The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease ATM MYC PMC10552637__F1 Metabolic cycle of tetrahydrofolate (THF) and the one-carbon (C1) metabolic pathway MTHFD1 HEL-S-51e MTHFD2 AMT MTHFD1L PMC2737697__F2 Genetic Susceptibility to Lupus: New Insights from fine mapping and genome-wide association studies HEL-S-62p TNFRSF4 BCR IRF7 STAT4 CRP TNLG2B TNFAIP3 PTPN22 PMC11903573__F2 HDACs and KATs that are involved in adipose tissue regulation PRDM16 USF1 UCP1 CIDEC HDAC1 FOXO1 PMC11903573__F3 KATs and HDACs play a role in glucose tolerance and insulin resistance TLR4 HDAC3 SIRT6 SF1 HDAC11 IRS1 SIRT1 FOXO1 PMC4796178__F1 Exercise-induced autophagy signaling TFEB BNIP3 MTOR SIRT1 TF PMC6838412__F7 Proposed mechanisms in SS MSG EIF4A2 IRF7 DROSHA IRF3 MAVS PMC4449431__F8 Schematic model illustrating the possible pathway targeting NCI-H929 cell by HM910 BAD CCND1 CDK4 CDK6 PMC9136877__F6 Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design ANGPT1 SRC RAC1 AXL PMC3758473__F2 Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease CRY1 FBXL3 CRY2 PER2 PMC7668088__F9 Conceptual model of OR2W3-evoked ASM relaxation and bronchodilation OR2W3 ORAI1 STIM1 CFTR INSR PMC8107117__F5 YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance YAP1 LATS1 LATS2 PMC8201174__F3 Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGFB and the Ubiquitin-Proteasome Pathway STUB1 BLM SMAD2 SMURF2 SMAD4 NOX4 SKP2 PMC8345866__F8 Summary scheme for potential drugs to target the Wnt-AMPK-mTOR pathway during epileptogenesis WNT8B FOXG1 SFRP1 PORCN PDK4 MTOR PMC6646331__F5 Glutamatergic synapse (path:hsa04724) pathway mapping of the protein targets of DPCs: The location of protein targets of DPCs in the KEGG pathway hsa04724 is represented in yellow and red coloured boxes, red ones are specific to mGluRs TH GLO1 ARG1 BAAT GLA PMC7402353__F3 13 major receptor groups involved in itch and their endogenous pruritogens TRPA1 TRPV1 ITCH PMC9409283__F2 Analysis of Amino Acids in the Roots of Tamarix ramosissima by Application of Exogenous Potassium (K+) under NaCl Stress TH OCM ADM PMC8336468__F7 Clostridium cellulovorans Proteomic Responses to Butanol Stress TH PMC5995146__F2 Parkinson’s disease: From human genetics to clinical trials VPS35 SNCA PINK1 LRRK2 FBXO7 PMC3926967__F2 Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections TYK2 IFNAR2 JAK1 IFNAR1 IRS1 STAT3 PMC9224161__F4 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain ME1 PC GOT2 MPC1 CPT2 PDK4 HEL-S-133P NR1C1 HEL-S-32 HK2 PMC4454159__F2 Concept map of the cancer metabolic rewiring GLS2 HEL-S-51e CIT MTHFD2 HEL-S-133P PHGDH GLA MAL PMC3919979__F9 CNP action in the SRG GC CNP CFTR PMC7761947__F3 Signaling mechanisms for TRPM2 and TRPM8 activation IL16 TRPM2 TRPM8 PMC9326605__F1 DNA Hypomethylation May Contribute to Metabolic Recovery of Frozen Wood Frog Brains TDG TET3 TET2 TET1 PMC4454159__F1 Glutamine metabolic rewiring GLS2 NNT CIT MAL PMC4688904__F1 The glucocorticoid receptor, regulation of gene expression, and its clinical consequences POLR2A RORA PMC9224161__F2 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain ME1 PC GOT2 MPC1 CPT2 PDK4 HEL-S-133P NR1C1 HEL-S-32 HK2 GLS PMC7761947__F2 TRPM1 role in visual pathways MTOR MLSN2 TRPM1 CAMKK2 PMC4102943__F6 The proposed point at which dFdC metabolism interacts with the Kennedy pathway that converts choline to phosphatidylcholine, resulting in formation of GdPC, and the impact of linoleate on that reaction CDA PMC7060963__F5 Transcriptomics and pathway analysis of CRISPLD1-KO-hiPSC-CM INA L1CAM RHO TNF RYR2 PMC11004819__F3 Pharmacogenomics-based systematic review of coronary artery disease based on personalized medicine procedure SQLE APOA4 LIPC SCARB1 ABCG8 ABCG5 APOC2 APOC1 APOC3 PDIA2 MTTP HMGCR CYP7A1 DGAT1 APOB PLTP ACSS1 FDFT1 LPL APOA5 LDLR SOAT1 ABCA1 PMC11530992__F1 Canonical pathway and non-canonical pathway of NFKB signaling pathway BCL10 BCR REL PMC4385749__F5 Diagram of the neural circuitry underlying delay eyeblink conditioning CS PC GC PMC6592230__F7 ATM/Chk/Greatwall/PP2A signaling model for normal mitotic exit (A) and for abnormal mitotic exit during recovery from mitotic DNA damage (B) PLK1 ENSA ATM CDC2 PMC6999766__F8 Schematic diagram summarizing the therapeutic effects of the flavonoid ingredients isolated from Abelmoschus manihot (L.) Medik flowers in multiple myeloma HK3 HK2 PMC4732610__F6 Transcriptional Analysis of T Cells Resident in Human Skin UGT1A3 CYBA TXNRD2 FOS GCLC MAPK10 NFE2L2 GPX1 MAPK14 MAOA NOX4 HMOX1 GPX3 MGST1 NFKB1 TXN2 GSTT2 HEL-S-44 HEL-75 CYP1A1 XDH JUNB SP1 TF PMC4732610__F5 Transcriptional Analysis of T Cells Resident in Human Skin IL10 TH CXCL1 CSF3 IL13 IL11 CXCL2 IFNB1 TNF IL5 IFNG IL15 IL3 IL2 IL4 CSF2 CSF1 TGFB1 PMC2861286__F1 Proposed mechanism for vitamin D’s action on the innate immune system NR1i1 TLR1 PMC2908542__F8 Sirtuin 3, a New Target of PGC-1A, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis UCP1 GPX1 SIRT3 PMC8200410__F6 Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report GOT2 OXCT1 HEL-S-133P ROS1 PMC4908334__F5 SBGN representation of the haematopoiesis gene regulatory network generated by ChiBE () based on our BioPAX model FLI1 RUNX1 ERG SMAD6 ZFPM1 HHEX GATA2 GATA1 PMC11523104__F1 2–3% of glucose entering the cell is diverted from glycolysis into the hexosamine biosynthetic pathway (HBP) NAGK OGA OGT PMC5547388__F5 MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells EGF BAD BTC GRB2 SHE MTOR NRG4 JUN PMC7326927__F10 Summary of the effects of MPP+ and rotenone exposure on IL4-induced immune response on primary glial cell cultures CD200 IL4 HIF1A CD200R1 PFKP PMC4137222__F2 HBV interaction with the ER-associated degradation pathway EDEM1 EDEM2 EDEM3 PMC8891559__F2 Necroptosis in alcoholic liver disease and hepatic pathogenesis HMGB1 RIPK1 OGT RIPK3 PSMA2 CYP2E1 GLA MLKL PSMC1 PMC8891559__F1 Necroptosis in alcoholic liver disease and hepatic pathogenesis HMGB1 CXCL1 TRADD RIPK3 CXCL2 IFNAR1 MAP3K7IP1 PPM1B TLR3 ZBP1 NLRP3 RIPK1 TLR4 CYLD TRAF2 FADD MLKL PMC7307818__F7 Possible mechanisms responsible for the effects of paeonol against human colorectal cancer HCT116 cells GSK3B AXIN1 CCND1 CDK4 CDK6 PMC6567800__F7 Anti-shock mechanisms of molecular hydrogen during sepsis FGF21 GHRL TLR4 GSK3B RHO RAC1 PMC12027419__F5 Identification of key players in burn injury-related REC network NAPEPLD ABHD6 FAAH PMC7423769__F4 Proposed network for BMP signaling in regulating energy metabolism via mTOR and HIF-1 BMP2 MSC BMP7 PMC6567800__F6 Anti-apoptosis mechanisms of molecular hydrogen in sepsis TLR4 GSK3B MYD88 PMC4944539__F1 FGF/FGFR signaling pathways FRS2 GRB2 SOS1 PMC5570368__F7 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing EP300 PPARG JUN NR1C1 PMC5216813__F6 Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer CYP27A1 CYP46A1 CYP8B1 CYP7B1 CYP51A1 PMC8301600__F2 Alphaherpesvirus-mediated innate immune evasion TBK1 CGAS PUS3 IRF3 MYD88 TLR1 IFNAR1 AIM2 IFI16 PMC8966199__F8 Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780) CASP12 COPE ATP6 F2 ATF4 SVIP SKP1 TRAF2 SELL BAX PMC2225983__F3 PI3K-AKT pathway is transcriptionally regulated throughout the lactation cycle BAD CDC37 MTOR RHEB PMC5570368__F8 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing NR3C1 NR1C2 NR1A2 PPARG NR1C1 RXRA PMC8531217__F12 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development ACE2 TMPRSS2 PMC5274707__F1 Neutrophil crosstalk with immune and humoral cells and relevant chemical signals that influence and compose the inflammatory response and pathway to resolution via the neutrophil TLR4 TLR9 MPO CXCL9 TLR3 PMC11751205__F5 Autophagy pathways in normal and burned tissues MFN1 PINK1 BNIP3 USP30 TOMM20 PMC8750666__F9 Building a Foundation for Precision Onco-Nutrition: Docosahexaenoic Acid and Breast Cancer TSC2 ULK1 TSC1 PC ELF3 RHO EIF4E RPS6 EIF4B IRS1 RHEB INSR PMC6580575__F4 Mechanistic diagram of NGF and ILM-mediated proliferation promotion by regulating cell cycle of Müller cells NGF CDK2 CCND1 CDK4 PMC8685280__F5 Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment TH LEP SET FOXP3 PMC3000610__F6 Proposed working hypothesis TLR4 SPHK1 SKI SPHK2 PMC9293537__F5 Pharmacological Approaches to Decelerate Aging: A Promising Path TSC1 IRS1 GPX7 PMC6212521__F8 Schemes of normoxic vs CS FH GC MAL PMC5693908__F1 Inflammatory signaling pathways in hematopoietic cells and potential therapeutic targets for myeloid malignancies TRADD STAT2 IRF9 ATF2 TRAF6 IFNGR2 IFNAR2 IL6 MYD88 IFNG TRAF2 TIRAP STAT3 PMC11379071__F8 Diagram illustrating the underlying molecular mechanism identified in the present study YTHDF2 METTL3 YAP1 PSAT1 ATF4 CNOT1 LATS2 PMC6212521__F7 Schemes of normoxic vs CS FH MAL PMC5523465__F1A Checks and Balances: the Glucocorticoid Receptor and NFKB in Good Times and Bad CORT NR3C1 FKBP5 FKBP4 PMC4480752__F7 miR-93 Promotes Cell Proliferation in Gliomas through Activation of PI3K/Akt Signaling Pathway PHLPP2 FOXO3A CCND1 PTEN PMC4701972__F2 Regulation of the Hippo pathway by upstream signals NF2 TAOK3 LATS1 RHO CDC2 LATS2 TAOK1 TAOK2 PMC6259838__F1 Cell cycle pathway represented in KEGG E2F4 SMAD2 SMAD4 STAG1 DBF4 ORC3 CDK7 STAG2 CDC6 SMC3 CDK2 CDC2 RAD21 PCNA SKP2 MYT1 PMC7038792__F1 NF2/merlin signaling and potential therapeutic targets in NF2 LIN28B EGFR MYC CD44 LATS1 LATS2 RHEB TSC2 TSC1 CXCR4 SRC EPHA2 JUN PMC4571436__F2 CXCR3 Isoforms play functional roles in seemingly opposing directions SOCS3 CXCL9 SRC MCL1 BACH1 STAT3 PMC3558412__F1 Diagrammatic overview of the late stages of the HIV life-cycle TSG101 ABCE1 PMC7832464__F2 Progression of SARS-CoV-2 infection and inflammation FCN1 ACE2 IL1B ADAM17 PMC9709483__F2 Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms NAMPT RORA PER2 PMC7927067__F9 STAT1 and STAT3 regulation of inflammation and growth arrest phenotypes in senescent preadipocytes STAT1 ISG15 CGAS CXCL10 MX2 STAT3 PMC6209233__F10 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential VASP BAD FYN HEL-S-28 SHE ARHA PTEN PMC9641401__F5 Krüppel-like factor 6 splice variant 1 in the development, diagnosis, and possible treatment strategies for non-small cell lung cancer CCL24 TWIST1 CDH2 KLF6 BAX PMC6606851__F10 Summary of the dominant effects of WNT5A mutations on skeletal morphogenesis WNT3A PMC3122626__F4 Key cellular signaling cascades regulating morphogenesis in C LMO1 NRG1 RAC1 ACE2 PMC5372601__F1 RAS/RAF/MEK aberrant signaling and mechanisms of resistance to inhibition in melanoma EGFR GRB2 PTEN MTOR PMC4699681__F1 Signaling pathways activated in chondrocytes by fibronectin fragments MMP10 LIF SRC PMC11608501__F11 Proposed schematic describes the mechanism of TRPM7-induced pyroptosis in SE NLRP3 TRPM7 GSDMD STAT3 PMC3122626__F9 The calcineurin signaling pathway in C MID1 HEL-S-84 FPR1 CPA2 CPA1 PMC8006187__F1 Network-based virus-host interaction prediction with application to SARS-CoV-2 IRF3 GAL ACE2 PMC3589914__F5 Regulatory circuits operating in osteoblast lineage cells RUNX2 BMP2 ATF4 HDAC5 DKFZp781O1323 PMC9386474__F1 Oncogenic signaling pathway-related long non-coding RNAs for predicting prognosis and immunotherapy response in breast cancer SET MYC TGFA PMC8201567__F8 Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway STAT3 PMC2828057__F1 Genetic factors influencing cytarabine therapy CDA RRM1 RRM2 DCTD PMC6121884__F3 Akt/mTOR pathway in schizophrenia TSC2 ULK1 ERBB4 TSC1 DISC1 CDK5 NRG1 MTOR PMC7670535__F1 Role of AKAP13 in cardiac function MEF2C PMC9260392__F1 Targeting Novel Regulated Cell Death: Pyroptosis, Necroptosis, and Ferroptosis in Diabetic Retinopathy NLRP3 IL1B GSDMD PMC3693006__F4 Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells TLR4 TRAF6 MYD88 TIRAP MAL PMC7232694__F2 Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction TLR9 SETDB1 YY1 RAD52 POLN SP1 FKBP2 PCNA PMC3027599__F6 Ingenuity Pathway Analysis Network 2 depicting relationship among up-regulation Genes in SL1344 vs SB1117 infection groups at 8 hours RHOV RHOB PMC3027599__F5 Ingenuity pathway Analysis network 1 depicting relationships among up-regulated genes in SB300 infection group relative to that of SB1117 infection group at 8 hours PCSK9 PMAIP1 LY96 IRF4 SAA2 PMC5352145__F10 Genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel PDE1C EIF5B ROBO3 GCLC RPL36 AAG1 APRT RPL6 CBL PMC8608404__F4 Two models for coordination between TLS and DSB Repair by REV7 SHLD3 SHLD2 SHLD1 TRIP13 PMC8608404__F3 REV7 controls pathway choice at DSBs SHLD3 SHLD2 SHLD1 BRCA1 TRIP13 PMC5884111__F6 Cartoon schematic showing the mTOR signaling pathway in cells TSC2 TSC1 EGFR PTEN RHEB PMC8608404__F2 REV7 Controls Pathway Choice at Stalled Replication Forks REV1 PRIMPOL POLN PCNA TRIP13 PMC3216677__F1 Proposed estrogen receptor (ER)-activated signaling pathways involved in vasodilation EGF EGFR TF PMC3418323__F5 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor FGF4 LIF TBX3 GRB2 JAK1 PMC3418323__F4 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor FGF4 LIF GSK3B STAT3 PMC3418323__F2 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor LIF JAK1 STAT3 PMC7214455__F1 Taking aim with IAP antagonists at triple-negative breast cancer: a moving target no more? CASP3 RIPK1 TRADD RIPK3 TRAF2 CASP8 FADD MLKL PMC8222712__F1 Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects CD1A MYC CD44 CCL5 HEL-S-87p MTOR ARG1 PMC6121884__F1 Mammalian target of rapamycin (mTOR) pathway TSC2 ULK1 TSC1 PTEN MTOR IRS1 PMC9446768__F1 Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases TH UCP1 CIDEA PMC8404464__F4 Network medicine in Cardiovascular Research IL10 NEDD9 PAH PSMD3 PMC3861374__F4 Mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) IGF1R HGF EGFR PTEN PMC5974615__F1 Regulatory Network of ARF in Cancer Development MDM2 CDK4 CDK6 PMC7947908__F5 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases HEL-S-62p ATF2 APC PMC7947908__F4 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases TNLG8A DERA CR1 PMC8222783__F4 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway BRAF NRAS TRAF6 IRAK4 PLCG2 MYD88 MTOR BLK CD79B VPREB1 CD79A BTK CARD11 FYN BCL10 BASH LYN SYK GNB1 CD19 PMC3726443__F6 Full Transcriptome Analysis of Early Dorsoventral Patterning in Zebrafish LRP6 GSC ZIC3 PMC3983488__F1 Matricellular TSP1 via CD47 restricts NO-sGC-cGMP signaling SIRPA CD47 SRC CD36 PMC9464960__F3 MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives DGAT1 INSIG1 CIDEC P4HA1 RELB YY1 RORA KLF6 SIRT1 GLS PMC7284928__F2 Protein-protein connection networks among the eight genes involved in PPARG-MI signaling pathways RELA MYD88 PPARG ACADM PMC6880621__F2 NLRC5’s role in renal diseases TGFBI HK2 PMC9017576__F1 TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook NLRP3 CD6 TXNIP TNF PMC3493640__F1 Multi-omic map of the lipid-producing yeast Rhodosporidium toruloides ERG ACO2 IDI1 IPP HK2 MDH2 HEL-S-162eP PMC3390194__F1 Personalized Medicine and Inhibition of EGFR Signaling in Lung Cancer EGF EGFR PTEN MTOR TGFA PMC4291046__F1 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway IKBKB IL10 TSC2 SOCS2 TSC1 IL6 PTEN IL4 TNF MTOR SOCS1 PMC5078108__F1 PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma TSC2 BAD TSC1 PDK2 GSK3B MDM2 GRB2 GIP PTEN RHEB BAX PMC6021761__F3 Discovery of IDO1 inhibitors: from bench to bedside IDO1 KYNU AHR KMO IDO2 PMC5660707__F5 Scheme of magnesium and calcium transporters and their interaction in the AD brain TRPM6 APP MTOR IL1B TRPM7 PMC11847631__F3 Expression of inflammatory mediators induced by pathogen invasion TLR4 CCL2 MYD88 TNF PMC5660707__F2 Model describing the copper transport system and its association with AD ATP7B COX17 ATP7A ATOX1 GSK3B CCS PMC5410960__F16 Top illustration shows disruptions in normal cell survival and normal apoptosis in glioblastoma EGF EGFR MTOR PMC8222783__F3 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway BRAF TLR9 NRAS TRAF6 IRAK4 PLCG2 MYD88 MTOR BLK CD79B CD79A BTK CARD11 FYN BCL10 BCR BASH LYN SYK GNB1 CD19 PMC8684172__F2 Regulated cell death: discovery, features and implications for neurodegenerative diseases NLRP3 NLRC4 NLRP1 AIM2 GSDMD PMC8222783__F1 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway BRAF TLR9 NRAS TRAF6 IRAK4 PLCG2 MYD88 MTOR BLK CD79B CD79A BTK CARD11 FYN BCL10 BCR BASH LYN SYK GNB1 CD19 PMC5733868__F4 Path diagram of the nuclear factor kappa B (NFKB) signalling pathway EGF LTA NGF RELA RELB IL2 IL4 REL PMC4926490__F1 An illustration of the genesis of exosomal aquaporin-2 (AQP2) in renal collecting duct principal cells AQP3 AVP AQP2 AQP4 PMC4058194__F8 RTK/RAS/PI(3)K signaling pathway EGFR PTEN GRIA2 PMC6032173__F3 Regulatory mechanisms of selected modifications in PPARG THRAP3 PRDM16 CDK5 CDK9 PPM1B SIRT1 PER2 DOK1 CDK7 PMC5341000__F10 Proposed scheme for the role of male sex on energy metabolism in the diabetic kidney SET PMC8505728__F7 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans DES THOP1 PMC8505728__F6 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans TH CD58 CD6 APC CD96 CTLA4 SPN tal-1 PTPRC AGA POLE PTPRO CD2 CD22 CD40 CD80 CD226 ICOS POLI CD36 PMC8469949__F2 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? RNASEL TBK1 IRF7 IRF3 RAC1 NOD2 MAVS PMC4058194__F6 In mTOR signaling pathway, there is the triplet of genes codes for proteins (orange nodes), and the pair (ATM and TP53) corresponds to interacting proteins in the cell cycle pathway (light blue nodes) TSC2 TSC1 ATM EGFR MDM2 STK11 MTOR PMC8469949__F1 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? TBK1 STAT1 STAT2 IRF7 IRF3 IFNAR2 MYD88 JAK1 IFNAR1 MAVS PMC3411810__F6 BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines GSK3B PTEN PMC8869457__F1 Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer ZNRF3 RNF43 APC LRP5 LRP6 ARHA RAC1 VANGL1 BCL9 PMC10288531__F3A Differential Pathway Expression of Antigen Processing and Presentation CANX CUTA HEL-S-99n B2M TNF IFNG TAPBP PMC7922891__F10 Graphical summary of expression profiling of human lymphoblastoid cells derived from an SS patient IL15RA BIN2 SELP KLF3 PMC5985418__F1 Fibroblast growth factor-23 (FGF23) pathways FGF23 FGFR1 DCT TRPV5 FGFR3 WNK4 SGK1 CYP27B1 NHERF1 PMC7863362__F4 Compared with photoautotrophy, the expression changes of photorespiration biosynthesis pathway in mixotrophy PGP AGXT HPR PMC5053262__F1 UPRmt signal transduction pathway in mammals and worms ELF2 UBL5 EBP CLPP PMC7863362__F5 Expression changes of central carbon and energy metabolic pathways CS GPT HEL-S-162eP PMC8603450__F1 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 BCAT2 PIR LCN2 HEL110 DKFZp686F0183 SLC3A2 TF PMC1489534__F3 Regulation of cell wall gene expression during the cell cycle (A) and in response to external stimuli (B) GSC2 SPI1 GAS1 ACE2 PMC8603450__F2 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway STEAP3 LCN2 HEL110 TF PMC8223826__F1 Exosomes in diagnosis and treatment of colorectal cancer CD9 CD63 CD81 PMC5912962__F1 Comprehensive Review of Genetic Factors Contributing to Head and Neck Squamous Cell Carcinoma (HNSCC) Development in Low-Risk, Non-Traditional Patients FANCA ATR FANCG PMC3410226__F1 Insulin signaling pathway ENPP1 CRP TRIB3 PHLPP1 PMC4211543__F1 PrPCsignaling via SFKs BACE1 FYN MBP EGFR SRC PMC7190874__F4 Heart analysis HEL-S-62p C1orf51 RPL27 DRD2 RPL12 JUN RPL3 TMOD4 CD19 CRY1 MYOT H2AB1 c-fgr CDK105 NMB FGF2 MMP9 ATF3 HEL-S-310 RPL17 DBP NFIL3 CD80 HSPA1A HEL-S-72p PMC7190874__F7 Kidney analysis SPARC UCP1 PCK1 FBN1 PDK4 HEL-S-104 COL1A1 UBC NPY IGFBP1 LPL COL1A2 ITGAX CIDEA FASN PMC9256076__F1 Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review) CD14 BCAT1 HEL-S-11 MYC UCP2 CD36 PMC8949121__F6 Integration of Transcriptomic and Proteomic Analyses Reveals New Insights into the Regulation of Immune Pathways in Midgut of Samia ricini upon SariNPV Infection SIAH1 APC LRP5 LRP6 SKP1 RBX1 PMC10288531__F2A Differential Pathway Expression of Cardiac Muscle Contraction Pathway TH TNC TEC HRC CASQ2 TRDN PMC8319020__F1 Sialic acid O-acetylation: From biosynthesis to roles in health and disease CMAS CAS1 SLC35A1 SIAE PMC7824874__F3 The IRF3 signaling pathway by the UPS following LPS exposure TBK1 CYLD CXCL10 TRIM21 DTX4 IRF3 TRIM27 PMC7824874__F2 Key contributions of the UPS to the regulation of the NFKB signaling pathway in response to LPS TLR4 TRAF6 MYD88 TNF OTULIN PMC4757551__F5 Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01 ASNS PCK2 PMC2722510__F7 Proposed pathway involved in the regulation of the osteoblast F-actin cytoskeleton, based upon previous literature and the current experimental results ARHA PTH GIP PMC11646733__F1 Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGFB/Smad3 pathway modulation SIRT1 HK2 PMC3679459__F1 TRAIL apoptotic pathway BCL2 FADD BAX PMC4905055__F2 Tumor metabolism provides precursors for biomacromolecule synthesis PDHA1 SPHK1 ACLY EHHADH HEL-S-133P PGAM2 SDHA HEL-S-162eP PMC1952634__F4 Evolving biology and treatment of prostate cancer SHBG GRB2 PTEN PMC9541002__F2 LINC00467: an oncogenic long noncoding RNA SIRT6 EZH2 HTRA3 PMC355851__F8 Proposed model for the observed inhibitory effects of Alpha-catulin and Alpha-catenin on the activation of cyclin D1 transcription CCND1 RHO PMC8140599__F3 Interaction network of selected proteins with changes in their abundance in the liver of rats exposed to distress and piracetam AP2A2 GANAB MAST3 CPT2 HTRA2 CANX COX2 MAST2 FADS2 SLC25A13 PSMA8 HEL-S-44 HEL113 AIM2 UGGT1 CDC42 PMC9616781__F1 Molecular Effects of Environmental Enrichment on Alzheimer’s Disease BACE1 PLG BDNF PMC9104724__F4 Yeast as a Model to Find New Drugs and Drug Targets for VPS13-Dependent Neurodegenerative Diseases RCN2 PMC8014260__F1 Toll‐like receptors in the pathogenesis of COVID‐19 IRF7 TRAF3 TRAF6 IRF3 IRAK4 PMC4479266__F8 Sry-type HMG box 18 Contributes to the differentiation of Bone Marrow-derived Mesenchymal Stem Cells to Endothelial Cells EGR1 VWF SOX18 MEF2C PMC3618530__F8 Interleukin-1B enhances cell migration through AP-1 and NFKB pathway dependent FGF2 expression in human corneal endothelial cells TRAF6 IL1R1 IL1B PMC8727820__F3 Interaction between gut microbiome and anti-tumor drug therapy LTA IRAK1 CCND1 BCL2 KRT7 MYD88 MTOR RHEB STAT3 BAX PMC3253558__F1 Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication CRY1 SNCA CHGB c-fgr ZNF397 ZSCAN2 ZW10 MLX STK33 UTP18 ZNF35 MNAT1 PEX2 BMX NR1C2 PPP2CA XPA CSRP3 NUP107 PCNP BFAR AURKC PJA2 RPS6KA2 PMC6215106__F7 Autophagy in response to the Zearalenone–induced G2/M cell cycle arrest CCNB1 CDC25B MTOR PMC2888474__F2 Genetic Alterations in Glioblastoma Occur Frequently in 3 Cellular Signaling Pathways PDGFRA CDKN2C DKFZp781B1423 EGFR PTEN RB1 CDKN2A CDK6 CCND2 NF1 CDKN2B ERBB2 MDM2 CDK4 PMC3862694__F10 PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity TSC2 TSC1 PTEN IRS1 RHEB PMC7015041__F8 Molecular mechanisms involved in PLAG1 regulation in OC cells IGF1R IGF2 IRS1 PLAG1 PMC8883486__F1 Canonical and non-canonical NFKB pathway RELB IL6 LTBR PMC8330570__F7 THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy THADA PMC6581583__F3 Inflammatory response due to the signaling cascade when HMGB-1 interacts with surface receptors TLR2/TLR4, TREM1, and RAGE HMGB1 IRAK1 IRAK2 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR4 TREM1 GRB2 SRC CDC42 PMC7864012__F2 One-carbon metabolism around the folate cycle, methionine cycle and trans-sulfuration pathway CTH HEL-S-61p MTR DHFR GLDC PMC9143066__F1 Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention PMC5134889__F2 Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases PLCG1 ITK LCK ZAP70 LAT PMC7864012__F1 Serine-glycine biosynthesis pathway PSAT1 PSPH PHGDH PMC2233890__F4 Multiple ERK scaffold regulate growth factor and adhesion signaling ARF5 ARF6 ARF3 ARF1 CDC42 PMC10879038__F4 Programmed endothelial cell death pathways RIPK1 GPX4 RIPK3 MTOR PMC10879038__F3 GSK‐3B as a converging point in key signaling pathways regulating BBB integrity post‐stroke TSC2 TSC1 APC LRP5 LRP6 UNC5B PMC6660834__F1 Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease NLK APC LRP5 LRP6 ARHA SFRP5 PMC10528086__F2 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex APC LRP5 LRP6 MTOR PMC10528086__F1 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex APC LRP5 LRP6 PMC2747034__F1 MTDH/AEG-1 promotes tumor progression through the integration of multiple signaling pathways LEF1 DPYD GSK3B MYC ABCC11 MTDH ALDH3A1 BNIP3 AKR1C2 HMOX1 PMC7719303__F2 Inflammation and ROS NLRP3 ROMO1 RIPK1 IL16 TRADD TXNIP CXCL12 DIABLO TRAF2 IL1B FADD NOXA1 PMC2657775__F7 Enrichment of TGF-beta signaling pathway NODAL SMAD2 SMAD4 ARHA IFNG PMC2657775__F6 Enrichment of Wnt signaling pathway ROCK2 NLK APC PROC CER1 SMAD4 ARHA PMC308834__F1 A representative example of a plant pathway in MetaCyc GIP MAL PMC7073720__F4 Prostaglandin biosynthetic pathway COX2 PTGIS COX1 PTGES PMC2657775__F9 Enrichment of Jak-STAT signaling pathway PIN1 EPO IL6 PMC11161882__F3 Differentially regulated pathways obtained from IPA analysis A SYBU NBL1 SOX18 SORD EIF1AX RPL3 PMC2790404__F2 Viral infection elicits a variety of antiviral cellular responses IFNE IRF3 TLR3 PMC6142689__F5 Pathway of NRF2-mediated oxidative stress response GSTT1 CP PMC6616367__F1 Tumor necrosis factor (TNF) receptor, IkappaB kinase/nuclear factor kappa B (IKK/NFKB), c-Jun N-terminal kinase (JNK), and apoptosis in hepatocellular carcinoma (HCC) development RIPK1 TRADD RIPK3 TNF TG TRAF2 FADD TAB3 PMC6142689__F3 Pathway of calcium signaling predicted by IPA NFATC1 TPM3 HDAC11 CP PMC3572677__F1 Scheme of apoptosis pathways FADD PMC8363758__F6 Schematic illustrating RhoA-actin-serum response factor (SRF) signalling pathway ARHA NR1D1 PER2 PER1 PMC8496250__F1 Biological Significance of Long noncoding RNAs Dysregulation and their Mechanism of Regulating Signaling Pathways in Cervical Cancer APC CCND1 FRAT1 MTOR FRAT2 PMC3110643__F7 Cartoon representing CsA-mediated activation of TGF B1-dependent signaling leading to epithelial-mesenchymal transition in epidermoid carcinoma cells SMAD2 SMAD4 CDH2 SP1 PMC3101847__F1 Pathways that regulate aging TSC2 TSC1 RHEB PMC2552992__F9 Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease EGR1 E2F4 ATG3 HDAC2 PMC6348202__F2 Proteomic and Functional Analysis Reveals an Increased Chk1 Activity in Lung Cells that Contributes to Cisplatin Resistance(A) Identification of genes involved in differential cisplatin response EGF ATM IL22 TPO RHO PTEN ATR CBL PMC7081792__F1 Hippo and hyperplasia – TEAD promotes mTORC1 activation post-injury LATS1 PTEN LATS2 RHEB PMC8745114__F1 B Lineage Cells in ANCA-Associated Vasculitis PC BCR GC PMC3777492__F1 IGFBP5 enters cells through its own surface receptor or by freely diffusing into the cytoplasm IGF1 SHH RHO RAF1 IGFBP5 PMC2879563__F1 Subdivision of the estrogen metabolic pathway NAT2 UGT2B11 HEL-S-22 PMC5040721__F4 Possible antagonistic effects of obesity on myocyte signaling to accelerate muscle atrophy KLF15 SOCS3 GC IL6 PTEN BNIP3 MTOR IL6R PMC5040721__F3 Possible adverse effects of obesity on osteoclast CCR2 TRADD TRAF5 GRB2 SRC TRAF6 IL6 MTOR TRAF2 IL6R PMC5040721__F2 Possible adverse effects of obesity on osteoblasts MGP RUNX2 SOST GSK3B FSTL1 SHE PTH IL6 RHO MTOR IL6R FOXO1 ATF4 GC GRB2 STAT3 PMC9162455__F2 Down-regulation of MHC-II antigen presentation pathway by tumour cells and possible therapeutic targets STAT1 MHC2TA CREBBP EGFR MYC EZH2 CD74 IRF2 IFNG PMC5133177__F1 Mitochondrial Fe–S cluster biogenesis and Isu degradation PIM1 FES PMC9162455__F1 Down-regulation of MHC-I antigen processing pathway by tumour cells and possible therapeutic targets STAT1 SPPL3 EGFR MYC SND1 GIP EZH2 B2M IRF-1 IFNG DUX4 PMC7996041__F5 Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery IRAK1 TRAF6 IRAK4 MYD88 PMC9441765__F3 Emerging roles of ferroptosis in glioma GPX4 LPCAT3 FACL4 SLC7A11 SLC3A2 SOCS1 PMC8042664__F5 Schematic model IL18 IL1B PMC2913704__F6 TGFB1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation SMAD2 SMAD4 NOTCH1 TGFB1 PMC9441765__F5 Emerging roles of ferroptosis in glioma GPX4 SLC7A11 ATF4 TFR2 PMC7764345__F1 Insulin signaling pathway; Insulin stimulates the insulin receptor (IR), leading to phosphorylation of insulin receptor substrate (IRS) IRS1 PMC4789572__F7 Circadian-disruption-induced gene expression changes in rodent mammary tissues CASP3 TSC2 CDR2 PERP BCR ATM CDK2 FOS MYC MDM2 PTEN ATR PMC7803292__F15 Involvement of the Akt and Kras pathway in breast cancer MDM2 TPD52 CDK4 MTOR KLF3 KLF8 PMC9600751__F4 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions KLLN PTEN MTOR PARP4 PMC9600751__F3 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions RET BRAF NOX4 TPO PTEN MTOR PMC8797975__F5 Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease TSC2 RICTOR TSC1 APC ARHA PTEN RAC1 EIF4E MTOR DEPTOR AKT3 MLST8 PMC5505746__F1 Proposed potential mechanism of MDSC-mediated T cell suppression through LILRB1/2 and HLA-G interactions HLA-G LILRB2 LILRB1 ARG1 STAT3 PMC7203913__F9 Arabidopsis Plastidial Glucose-6-Phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum NADK HEL-S-64p RPE PXN PMC5035901__F4 KEGG pathway analysis of the validated miRNAs IGF1R GSK3B PTEN RB1 PI3 LEF1 CDKN1A PDGFA NFKB1 MDM2 GRB2 CASP9 CCND1 BCL2 MAPK1 SOS1 TGFA CREB5 PMC6358521__F1 Lessons learned from the study of human inborn errors of innate immunity TLR5 RELB IFNGR2 IRAK4 MYD88 TLR1 IL23R IL17RC IL12RB1 STAT1 ISG15 BCR RELA SHARPIN DCT CD40 TYK2 JAK1 IFNGR1 LTBR TIRAP STAT3 PMC7062075__F4 KEGG metabolic pathway map showing significantly differentially expressed genes within the cell cycle pathway for midgut control versus UCS E2F4 CDK2 SMAD4 CDK7 SKP2 PMC3769161__F7 Interleukin-17 Enhancement of the Interleukin-6 Signaling Cascade in Astrocytes SOCS3 IL17RC IL1B PMC6358521__F2 Lessons learned from the study of human inborn errors of innate immunity TBK1 TLR9 STAT2 IRF7 IRAK1 IRF8 IRF9 TRAF3 TRAF6 IRAK4 IRF3 MYD88 IFNAR1 TLR3 USP18 STAT1 ISG15 TLR8 TLR7 RELA TYK2 MAVS PMC7062075__F5 KEGG metabolic pathway map showing significantly differentially expressed genes within the cytokine–cytokine receptor interaction pathway for hindgut control versus UCS EDAR SAG TPO LEPR TNLG7C MPL PRL PMC7881328__F2 Anti–Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients PML CDA HM13 TANK MARCKS CS MAPK3 TRAF3 CCL2 HIF1A RIPK2 IFNG AHR HILPDA HEL-S-89n MMP25 HAMP CXCL10 VHL CD44 CXCL2 CCL4 CEBPA IL6 TNF EDN1 NFKBIA NFKB1 TRAF1 CCL20 GRB2 BCL2 MAP3K8 CD80 CCL23 P2RX4 PMC8516342__F8 Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3B YTHDF2 GSKIP HEL-S-11 GSK3B CYC1 PMC3193242__F7 The cross-talk between IKK family members in the MyD88 signaling pathway TBK1 TANK TRAF6 TAB3 PMC3137012__F8 Hypothesis of insulin signaling pathways associated with the regulation of CIDEA and CIDEC expression in human adipocytes CIDEC CIDEA PMC6271692__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules RORC NAMPT IL1A NRF EFNA1 RPRM VEGFA CCL4 IL6 CCL2 TNF IL12A STAT1 ZFP36 RELA CCR7 IL17A IL2 NOS2 PSMB9 CCL3 PMC7516013__F2 Farnesoid X receptor (FXR) regulates bile acid (BA) synthesis in a tissue-specific manner CYP8B1 FGF19 FGFR4 CYP7A1 PMC8269153__F3 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus AHR KEAP1 PMC8269153__F2 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus KEAP1 SIRT1 PMC8414903__F2 Ferroptosis Pathway by Ubiquitination STEAP3 SLC7A11 HEL-S-64p FES FTL TFRC SLC3A2 SLC11A2 PMC4808028__F9 Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism LTBP1 PMC11127239__F2 Cytotoxic effects of deoxynivalenol (DON) and mechanisms of diarrhea induction NLRP3 FTL CFTR PMC3131835__F3 Sphingosine 1-phosphate (S1P) generation and ALI-associated single-nucleotide polymorphism (SNPs) in the S1P biosynthetic pathway CD44 S1PR1 S1PR3 TNF PMC11965322__F1 STRING PPI analyses IGF1R GPX4 EPO DCLK1 SELENOP AGTR1 FLT4 DPP4 HIF1A HMOX1 ADAM17 FLT1 TSPAN12 TLR4 KDR PRP4K CFH TIMP3 TBX5 SELS IL1B IL10 ANGPT2 IHH RIDA ARHGEF7 LRP5 ADRB2 FZD4 ANTXR1 TNF NDP SP4 SMPD1 CXCL12 BDNF VEGFB TGFB1 GP1BA PMC3269658__F5 Differentiation pathways of CSCs CNTF SOX2 SOCS3 BMPR1A BMP2 GFAP JUNB MTOR ID1 ID3 BMP4 HES1 PMC7448569__F4 Gene expression profiles of the NF-kB signaling pathway in breast cancer CD14 NGF TRADD DAO RELB TRAF3 LTB TRAF6 PARP1 CNTF BTK COX2 LTA BCR ATM BASH LBP CD40 SYK TRAF2 LAT TIRAP ELL PMC9520296__F2 Pyroptosis as a candidate therapeutic target for Alzheimer’s disease TIGAR MAF NLRP3 GSK3B ABO IL1B GSDMD PMC8506221__F5 Schematic molecular pathway of LE regarding ICAM-1 dan E-Cadherin expression TLR4 AHR PMC7167284__F3 Chronic HCV replication in liver cells induces a multifaceted stress response CLDN1 EGFR LDLR NPC1L1 CD81 PMC8465124__F1 Splice and Dice: Intronic microRNAs, Splicing and Cancer DBR1 DGCR8 DROSHA PMC3482543__F7 Toll-Like Receptor 2-Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice TLR4 ARHA TNF PMC5206567__F7 The locus coeruleus (LC) pathway to cortex and its involvement in stress GALR3 GALR1 PMC6167442__F2 Detailed diagram for fatty acid and phospholipid synthesis in C C1S PSD PMC2329845__F2 IPA of the genes encompassed by the conserved 166 signatures and belonging to the Wnt signal transduction pathway PIN1 CD44 PARP1 AXIN2 WIF1 JUN HDAC1 TCF4 SOX9 PMC6782198__F7 Postreceptor adaptations of the cAMP pathway observed in response to chronic antidepressant treatment PDE4B PDE4A BDNF PMC3826451__F4 Intracellular PRR signaling pathways involved in RSV and hMPV-induced gene expression NLRP3 IL16 IRF3 NOD2 MAVS PMC6613384__F3 Protective effects of fibroblast growth factor 21 in cardiovascular disease FGF21 ABCA1 ACE2 PMC8895452__F8 RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues COX2 FASN STAT3 PMC3826451__F2 Toll-Like Receptors (TLR) signaling pathway involved in RSV and hMPV-induced gene expression TLR8 TLR7 TLR4 IRF3 MYD88 TLR3 PMC7448569__F6 Gene expression profiles of the IL-17 signaling pathway in the breast cancer group TH IL2 REL FADD ELL PMC7448569__F5 Gene expression profiles of the C-type lectin receptor signaling pathway in the breast cancer group NPAT SET STAT2 FRK CYLD RELB IL2 IL11 IL6 IL-21 PMC9326442__F4 Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome IGF1R IGF1 MTOR STAT3 PMC9308248__F3 Promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors TSC2 TSC1 DEPTOR RHEB MLST8 PMC9609612__F12 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 YAP1 LATS1 LATS2 PMC4708174__F1 PI3K–AKT–mTOR pathway and drug targets TSC2 TSC1 GRB2 PTEN RPS6 TGFA IRS1 PMC3399428__F2 “Hpo signaling pathway in Mammals and the cross-talk with RASFF1A signaling.” Schematic representation of mammalian Hippo kinases cascade and interconnections between Hippo pathway and rassf1a protein signal NF2 TEF LATS1 RAF1 LATS2 FRMD6 PMC8039545__F7 Visualization of the differential gene regulation in PBMCs responding to A SET ERG REL PMC3707895__F6 NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS) TH FGFR1 NGF FGF2 PMC4394589__F6 Regulation of genes in IL1/TLR signaling pathways TBK1 CD14 SOCS3 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 IL16 CYLD IL33 TIRAP PMC2645538__F5 Possible neuroprotective mechanisms of mild mitochondrial uncoupling and caloric restriction in neurodegenerative diseases PARP1 BDNF SIRT1 PMC4394589__F5 Regulation of genes in the JAK/STAT signaling pathway SOCS2 SOCS3 IFNA4 IFNGR2 IFNA5 IFNA7 STAT1 IFNA6 IFNA8 IFNA13 IFNA14 SOCS4 PTPN1 IFNA10 SOCS7 IFNA2 PTPN6 IFNGR1 STAT2 IFNAR2 IL6 IFNAR1 STAT4 PIAS1 JAK3 TYK2 IL6ST JAK1 SOCS5 SOCS1 STAT3 PMC1876750__F2 Focal Adhesions Regulate AB Signaling & Cell Death in Alzheimer’s Disease BPTF KEAP1 PMC3523565__F1 Simplified scheme of the mitogen-activated protein kinase (MAPK) (RAS-RAF-MEK-ERK) signaling pathway.Notes:BRAF and NRAS are the most commonly mutated oncogenes in melanoma IGF1R BRAF NRAS PTEN MTOR ARAF PMC4222988__F3 A) Compensatory over-activation of signal transduction pathways induced by dual PI3K/mTOR inhibitors TSC2 EGF PAK1 TSC1 GRB2 INS PTEN GRB10 IRS1 RHEB INSR PMC4222988__F2 A) Compensatory over-activation of signal transduction pathways induced by rapamycin-mediated suppression of negative feedback loops TSC2 EGF PAK1 TSC1 GRB2 INS PTEN GRB10 IRS1 RHEB INSR PMC7756074__F7 Proposed model of the non-genomic actions of 1,25 dihydroxyvitamin D3 (1,25 D) in the lungs infected with SARS-CoV-2 STAT1 NR1i1 STAT2 IRF9 NFKB1 JAK1 TNF PMC4222988__F1 Signaling through PI3K/mTOR and Ras/Raf/MEK/ERK pathways is controlled by negative feedback loops TSC2 EGF PAK1 TSC1 EGFR GRB2 INS PTEN GRB10 IRS1 RHEB INSR PMC7797090__F5 Metabolic pathway of glycerol and glucose bioconversion to butanol in Clostridium sp HBD HEL-S-162eP PMC8753885__F3 Identification of cardiomyopathy-related core genes through human metabolic networks and expression data TH OMP NME6 NME2 GUK1 NME3 ADSS NME7 RRM2B GMPR2 RRM1 RRM2 GMPR PKLR APP NUDT2 AK5 COMP GLA PNP PMC4001054__F1 Proposed schematic models for the role of different lncRNAs (green) in neural development DLX2 DLX6 NEUROG1 SHH DLX5 DLX1 PMC5866379__F14 Cartoon showing hypothetical activation of CFTR by cigarette smoke extract via prostanoid and store-operated cAMP signaling pathways COX2 COX1 STIM1 CFTR PMC4980531__F2 Multifaceted regulation of T cell responses by ROS STAT4 STAT3 PMC3942790__F3 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches BMP6 HFE PMC3942790__F2 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches BMP6 TMPRSS6 HFE PMC6892740__F4 Major phospholipid biosynthetic pathways, genes involved, and subcellular localization of the encoded enzymes.PTDSS1,PCYT1A, andPISD from this study (all in red font) are associated with syndromic skeletal dysplasias PTDSS1 PC PCYT1B CHKA CEPT1 CHPT1 PCYT2 CHKB PISD PTDSS2 PEMT PMC4263682__F1 An example of a cluster illustrating Ras activation EGF APC EGFR GRB2 IQGAP1 RAC1 COIL S100B CDC42 PMC10530945__F1 Remodeling of Tumor Microenvironment by Nanozyme Combined cGAS–STING Signaling Pathway Agonist for Enhancing Cancer Immunotherapy CGAS IRF3 TNF PMC7307178__F8 Current model for the suppressive effect of MERS-CoV N protein on the RIG-I-induced type I/III IFN expression IRF3 TRIM25 IRF-1 PMC2678599__F7 Filia's role in ensuring euploidy of early cleavage embryos PLK1 ARHA AURKA PMC8194085__F1 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine HEL-S-62p CDA UMPS CAD DHODH PMC9253381__F5 Elabela Attenuates the TGFB1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis SMAD2 SMAD4 PMC3911241__F4 Examples of network refinements and reannotations HAAO KYNU KMO PMC3246786__F2 The role of CYLD in canonical and noncanonical NFKB pathway CYLD TRAF3 RELB CD40 TRAF2 PMC9265592__F1 Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives S1PR2 S1PR1 S1PR3 S1PR5 S1PR4 MTOR STAT3 PMC5852471__F8 Cell cycle arrest and apoptosis induced by BOS-102 in A549 cells CCND1 CDK4 BAX PMC8851844__F8 Cluster analysis of splenocyte microRNAs in the pig reveals key signal regulators of immunomodulation in the host during acute and chronic Toxoplasma gondii infection NPAT RAD1 STAT2 CYLD IRF9 RELB tal-1 PMC8345935__F1 New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates NODAL SMAD2 APC GSK3B LRP5 SMAD4 SRC LRP6 PMC4820109__F3 Association of MicroRNA-196a2 Variant with Response to Short-Acting B2-Agonist in COPD: An Egyptian Pilot Study DIAPH2 ACVR2B PDGFRA NODAL ROCK1 SMAD2 COL1A2 GRB2 TGFBR2 OCRL ITGAV PMC7485269__F4 Role of mTOR-dependent processes in NMJ alteration upon aging IGF1 MTOR PMC5080721__F4 mRNA microarray analysis (microarray cohort; n = 36 GBMs) revealed SVZ-dependent differential gene expression of key hierarchies of the Notch pathway MAML3 JAG2 HES4 DLL3 NOTCH3 PMC7485269__F2 (m)TOR pathways and downstream factors and processes in fly and mammals ELF2 ULK1 ELF5 ELF1 SUI1 TBC1D7 PTEN EIF4E IRS1 RHEB EIF5 TSC2 TFEB ELF3 EIF4B PMC7485269__F1 General organization and function of mammalian neuromuscular junction (NMJ) MUSK LRP4 ACHE PMC4085325__F4 SphK1/S1P/S1PR1 feed-forward loop sustain signals promoting colon tumorigenesis.Notes: SphK1 produces S1P, which is kept in the cell and/or is exported in the extracellular milieu S1PR1 SPHK1 SPNS2 STAT3 PMC11766336__F2 lncRNAs regulate the progression of malignant brain tumors MYC PMC8335817__F1 Interleukin‐25: New perspective and state‐of‐the‐art in cancer prognosis and treatment approaches TRADD EGFR TRAF6 IL25 IL17RB FADD STAT3 PMC4028717__F7 Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway FADD BAX PMC10487929__F10 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of the NISP SNCA PTGS2 CCL5 IL6 CCL2 TNF ACE2 IL1B IFNG PMC8766672__F2 Adaptive Mechanisms Make Lupin a Choice Crop for Acidic Soils Affected by Aluminum Toxicity CS ART1 PMC10487929__F11 Downstream effect analysis of molecules downstream ACE2 and upstream of the NISP in the network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD PTGS2 CCL5 IL6 CCL2 TNF IL1B PMC8194085__F3 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine EGF BRAF EGFR UMPS PTEN CAD DHODH STAT3 PMC8894518__F1 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy EGFR PTEN MTOR AXL PMC8023785__F1 Emerging concepts in the science of vaccine adjuvants IL10 CGAS TLR5 TLR9 IRF7 IRF3 MYD88 TNF TLR1 TLR3 NLRP3 TLR8 TLR7 TLR4 IL33 RAF1 TIRAP PMC9032397__F1 Vitamin D and Ocular Diseases: A Systematic Review CYP27A1 CYP2R1 DBP CYP24A1 CYP27B1 PMC8894518__F3 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy NOTCH2 NOTCH4 SMAD2 DLL4 APC JAG2 GSK3B SMAD4 NOTCH1 DLL3 NOTCH3 TGFBI PMC4458271__F2 Role of ceramides in neuronal apoptosis BAD UROS BAX PMC2682514__F1 Nodes with the highest relative betweenness centrality (in orange) and their interacting partners (blue) in the pancreatic cancer pathway EGFR GRB2 PMC9191826__F9 Combined treatment with anti‐PSMA CAR NK‐92 cell and anti‐PD‐L1 monoclonal antibody enhances the antitumour efficacy against castration‐resistant prostate cancer MICB MICA JAK1 MTOR PMC7488177__F2 Potential role of LRG1 in abnormal angiogenesis of diabetic nephropathy associated with TGFB1 signaling pathway SMAD2 SMAD1 HMFT1766 DKFZp781O1323 PMC3688662__F1A MODELS OF INSULIN RESISTANCE AND HEART FAILURE MTOR IRS1 FOXO1 PMC3219052__F1 SRC-3Δ4 isoform acts a signaling adaptor for EGF-dependent cancer cell migration and invasion EGF EGFR GRB2 NCK1 PMC8984119__F1 Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions PDC ACSS2 ACLY PMC8573113__F2 TDP-43 and ER Stress in Neurodegeneration: Friends or Foes? ATF4 EIF2A XBP1 PMC10562563__F1 Toll-Like Receptors (TLRs) signaling pathways, intra-, and inter-signaling crosstalk circuits, and their regulatory loops TBK1 TLR5 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 IFNG TLR8 TLR7 TLR4 TIRAP TAB3 PMC2669548__F1 Generalized schematic presentation of signaling pathways targeted by molecular therapies in malignant glioma EGFR PTEN MTOR PMC5525062__F2 Pathological pain and the neuroimmune interface HMGB1 CCR2 MMP9 CCL21 IL1R1 NRG1 CCL2 MYD88 TNF CR1 CXCR3 NLRP3 TLR4 MMP2 LYN CCR7 BDNF ADRBK1 IL1B PMC10136831__F3 Crosstalk between PGE2 and EGFR EGF CXCL1 EGFR SRC IL8RB TF PMC5722817__F9 Two HEB-dependent pathways of GDT17 cell development ID3 SOX4 IFNG CD24 PMC10136831__F1 Biosynthesis of prostaglandins COX2 COX1 PMC5380184__F2 Related cell process and diseases with potential disease biomarkers induced by particulate matter visualized by Pathway Studio GCLM SMAD6 CXCL8 TNF ID1 MX1 BMP4 IFNG GIG8 PDGFA STC2 CYP1A1 CSF2 OGG1 TGFB1 FIS1 SRXN1 PMC3528566__F2 Carbohydrate metabolism and ATP synthesis CS MTOR HEL-S-162eP PMC2773416__F6 Diagrammatic representation of intracellular pathways that lead to the production of IL-12p40 and the mechanisms of azithromycin (AZM) to inhibit the expression of IL-12p40 upon the stimulation of LPS/IFNG STAT1 TRAF6 JUNB MYD88 PMC5858703__F1 Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease SQLE EBP SC5D DHCR24 HMGCS1 HSD17B7 TM7SF2 CYP51A1 HMGCR ACAT1 DHCR7 FDFT1 FAXDC2 PMC420359__F8 RA regulation of reciprocal interactions between the visceral endoderm and mesoderm that control endothelial cell growth and vascular remodeling IHH VEGFA DKFZp781O1323 PMC2440498__F1 Signaling cascades initiated via TLR2- and TLR4-dependent activation TBK1 TLR4 TRAF6 IRF3 MYD88 TLR1 TIRAP PMC3520610__F5 Targeting the TGFB signalling pathway in disease SMAD2 SMAD4 TF PMC7672213__F6 Potential apoptotic pathway for anticancer effects of RPL against lung cancer ChAT ATM DIABLO PMC5423198__F5 Visual representation of the network generated by Ingenuity Pathway Analysis (IPA) HSF4 CD6 SHMT1 MYC EZR RB1 HIF1A KL HTATIP2 DDX11 HEL-S-76p CRLF2 MFAP1 NR3B3 NTRK2 RUVBL2 GNRHR CTDSPL ENO1 HUWE1 LMNA SULF1 EDNRB PRODH TYMS PPARG PMC2877979__F8 Schematic representation of some pathways and networks modified during strain improvement program according to results obtained after proteome comparison of NRRL 1951, Wis 54-1255, and AS-P-78 strains CS PMC3520610__F2 Targeting the TGFB signalling pathway in disease DROSHA SMAD4 TRAF6 RHO JUN TRAF4 PMC1479345__F7 Pathway analysis DBI TCEA2 POLR2A LAMP2 MYC PMC3520610__F1 Targeting the TGFB signalling pathway in disease SMAD2 DROSHA SMAD4 SKI PMC9402773__F2 Wnt Signaling Pathways: A Role in Pain Processing APC GSK3B PMC1479345__F6 Pathway analysis APOC1 FGFR3 APP ALAS2 FOXA3 HRAS BMP4 STAT3 THRSP CD36 BARX1 FOXA2 PMC1479345__F5 How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome PLK1 DCT DVL2 SF3A2 SF3A1 PMC1479345__F4 Pathway analysis SNCA HGF PCK1 DUSP9 BMP2 IGHMBP2 IKBKB HOXA13 LEP BTK GNAT1 FABP5 ABCE1 JUN TPSAB1 PMC1479345__F3 Pathway analysis CD82 ARHA TNF CDKN2A CRYAA HEL-S-102 HOMER2 SLC27A1 IL2 JUND YY1 RGS16 JUN TGFB1 PSMB10 FASN PMC12192670__F2 Mechanistic network of the pleiotropic regulatory effects of the vitamin D/VDR signaling pathway in the pathophysiological microenvironment of DFUs (by Figdraw) NR1i1 NGF BDNF TRPV1 PMC12192670__F1 Vitamin D metabolic activation and signaling pathways (by Figdraw) CYP27A1 DHCR7 DBP PMC4213374__F1 This figure illustrates some of the mechanisms by which CD40L can influence on different cell functions and the processes by which these altered cells can impact on host immunity in neoplastic diseases IL2 CD80 TF PMC9098154__F6 Schematic explaining the role of LINC00926 in orchestrating the regulation of WNT10B in order to regulate IFNG expression WNT10B IFNG PMC5096382__F4 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HEPATIC PROTEOME PROFILES IN 6 MONTH OLD ADULT OFFSPRING HEL-S-61p GSTM5 ALB HEL-S-134P GLUD1 ALDH2 PMC4833894__F1 Different molecules involved in the mTOR activation cascade EIF4E MTOR IRS1 PMC9520276__AF1 XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression NLRP3 CGAS IRF3 TGFB1 PMC9487300__F7 Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis HGF IL13 IL4 TNF TF PMC2850399__F7 Mevalonate pathway and the pleiotropic effects of statins RHO CDC42 PMC4879129__F8 ASS234 targets involved in AD pathogenesis BAD APP BAX PMC3159104__F4 Extrinsic signal pathways for regulating pluripotency during reprogramming BMPR2 SMAD2 LIF SMAD4 SMAD1 DKFZp781O1323 BMP4 STAT3 PMC2832126__F1 The multi-stage autophagic process ATG12 ATG3 AMBRA1 BCL2 PTEN UVRAG ATG10 DKFZp686F0183 RHEB PMC7695496__F2 Regulation of CH25H expression CH25H TLR4 KLF4 ATF3 IRF3 PMC7189756__F8 Downstream signaling events associated with type I interferon actions in nociceptors STAT1 EIF4E JAK1 STAT3 PMC3784243__F1 Role of the PD-1 Pathway in the Immune Response APC IL2 PTEN PMC2785769__F7 Proposed pathways for promotion (A) and progression genes (B) influenced by TLR4 EREG CCR2 AREG EGFR MYC CHST1 HBEGF CXCL2 CCL5 PTHLH HMGA1 TNC TLR4 GJA1 opn S100A8 RAN ARG1 PMC4175424__F2 Reactive Oxygen Species Adversely Impacts Bone Marrow Microenvironment in Diabetes ATM HEL-S-64p PTEN PMC9380933__F1 mRNA expression of NLRP3 and associated signalling molecules are differently regulated after SE elicited by pilocarpine or kainic acid NLRP3 HMGB1 IL18 TLR4 IL1B PMC8999182__F4 Physiological Electric Field: A Potential Construction Regulator of Human Brain Organoids TIAM1 EGFR RHO RAC1 CDC42 PMC6631235__F5 SAM on signal transduction pathways FOXM1 APEX1 SKP2 PMC8556195__F1 Plasticity of pancreatic cancer stem cells: implications in therapeutic resistance SOX2 SUFU APC JAG2 GSK3B MYC LRP5 CD44 LRP6 SMO PMC8713033__F6 Function of CARMIL1 in IL-1 Signaling IRAK1 IRAK2 CARMIL1 SRC MYD88 PMC9191896__F9 Pathway for sex hormone synthesis in the juvenile zebrafish HSD11B2 HSD3B1 HSD17B1 HSD17B3 CYP17A1 PMC6023969__F6 IL-37-mediated intracellular signaling cascades in eosinophils for the suppression of allergic airway inflammation NLRP3 TLR4 NLRC4 S100A9 PYCARD AIM2 TLR3 PMC9406959__F4 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma JAG2 PMC9406959__F7 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma LATS1 WNT5B LATS2 PMC3048376__F2 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli EGFR UNK TGFA TRAF2 PMC6370039__F1 Relationship between NFKB and autophagy YY1 DKFZp686F0183 PMC9406959__F2 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma KIF7 SUFU GLI3 SMO PMC6370039__F5 Relationship between the overexpression of YY1 and autophagy YY1 PTEN DKFZp686F0183 PMC3048376__F5 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli IL10 IGF1 IL6 MTOR TGFA STAT3 PMC8926145__F4 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function OTUB2 RUNX2 BMP2 SUFU SMO PMC5986142__F5 Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells SP2 GSK3B AIDA SMAD4 CDK7 PI3 PERP ATM CDK2 MDM2 SP1 ATR RAD21 MYT1 MAL PMC9406959__F8 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma CRABP2 ALDH1A3 RBP4 HEL-S-53e ALDH1A2 PMC6452163__F3 Classical neurotransmitters of clozapine neighborhood in A auto-layout format and B a gamut of multifunctional molecules identified by IPA core and functional analyses (see table 2) LEP GRINA ASIP CRH AgRP OXTR TRH UCN VEGFA NTS HRH3 HTR1F PMC8926145__F3 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function OTUB2 TRAF6 PMC3048376__F9 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli IL10 IGF1 TRAF6 IL6 IL4 MTOR TGFA IL1B IFNG STAT3 PMC7905081__F1 Core components of the Hippo signaling pathway and their regulation in the GV and MI-stage oocyte AMOT NF2 LATS1 LATS2 PMC3471227__F1 Hh pathway activation, inhibition, and mechanisms of drug resistance SUFU PTCH1 CCND1 SMO MTOR PMC3865928__F1 Citrobacter Infection and Wnt signaling APC GSK3B PMC5783456__F2 Ingenuity pathway analysis network identified with differential expressed genes RORC AKR1B10 EMX2 NR0B2 CCDC110 POU3F2 HEL-S-116 ABCA8 AMBP DEPTOR NR2A2 Pax9 FOXA2 RBP5 FOXA1 CHKA FOXA3 AKR1C4 ABCC5 NEUROD1 DPPA3 TLE2 PMC7377830__F2 Tomatidine-target genes associated with the top two KEGG pathways MAP2K1 BRAF RPS6KA1 FOS MAP2K2 RAF1 PMC4170887__F2 Gene interaction networks specific to the varying doses of 60Co radiation exposure AHR NFKB2 TNFSF10 ETV6 MBD2 FADD PCNA CRKL PMC10605613__F3 Cellular regulatory pathways involving PrPC protein in cancer FYN FLNA MMP11 MMP9 SATB1 PMC11049334__F2 Polyphenol-target network and associated signaling pathway and biological function NFKBIA NFKB1 PTGS2 MMP9 MAPK1 NOS2 TNF PMC5654500__F3 Lost in translocation: The function of the 18 kD translocator protein ALAS1 PCK1 GOPC PBR PMC5735915__F8 The c-Myc/miR-200b-3p/PRDX2 regulatory loop HEL-S-2a GSK3B PMC9519528__F1 Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency CER1 DES LPP CERK KDSR PMC4782360__F3 Pathway analysis illustrating the link between PM2.5-associated miRNAs in extracellular vesicles and biological pathways related to cardiovascular disease IL1F10 CCR3 IL36A IL36B CXCL8 IL6 MMP3 IL36RN VCAM1 CXCR4 IL36G CD40 CXCL12 CSF1 PMC12181760__F3 Pathways linking gut‐derived metabolite TMAO to CVDs via endothelial, cardiac fibroblast and cardiomyocytes dysfunction NLRP3 VCAM1 SMAD2 SMAD4 IL1B SIRT1 SIRT3 PMC9247141__F3 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis GPX4 FDX1 FDX2 SLC7A11 DPP4 SLC25A28 NFE2L2 GLS2 SLC3A2 PMC9247141__F1 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis GPX4 LPCAT3 STEAP3 FACL4 FTH1 SLC7A11 FTL SLC3A2 TF PMC3079783__F1 Leptin Signaling in Intestinal Epithelium Mediates Resistance to Enteric Infection by Entamoeba histolytica BAD SOCS3 BAX PMC7952990__F1 Oxidative stress leads to impaired GR function through proinflammatory signaling IL16 AHR IL33 TSLP STAT3 PMC3271643__F3 Putative mechanism of estrogen action in rat Sertoli cells EGFR CCND1 SRC PMC6798321__F2 Schematic presentation of Nipah virus (NiV)-induced modulation of type I interferon (IFN-I) production and signaling TBK1 STAT1 TLR8 TLR7 IRF7 RIGI IRF3 TRIM6 TRIM25 TLR3 MAVS PMC11806010__F4 Clec9a-initiated ITAM-Syk signaling cascade and downstream pathways NLRP3 CARD9 BCL10 RELB SYK CLEC9A PMC8506081__F2 Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer SRC SCRIB MAGI1 PMC7072699__F1 Metabolic pathway of sialic acids in mammalian cells GNE NEU2 NEU4 CMAS SLC35A1 NEU1 NANS NEU3 NANP PMC7905011__F7 Changing cell’s redox balance (NAD +/NADH) resulting from lactate conversion to pyruvate augments reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and mature skeletal muscle ATG12 ATG3 ATG10 MTOR PMC4270131__F10 C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NFKB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells EGFR NOXA1 PMC7285791__F4 Bioinformatics analysis of YRDC-mediated hub protein-protein interaction networks in NSCLC ANAPC11 UTP6 PSMB3 PRIM1 IMP4 POLR2D RFC3 MRPL20 PSMD3 PSMD13 PSMD12 GNL2 CCNB2 CCNB1 ORC1L DKC1 PCNA CCNE2 PMC6536578__F10 IPA network analyses of the 40 deregulated genes that we obtained from COMPARE analysis (see ) revealed the reconstruction of (A) NFKB network pathway and (B) HIF-1A network RPL17 CRELD1 B4GALT4 FAM216A POMZP3 PMC7824851__F4 PTEN modulates cell survival and proliferation by suppressing PI3K/Akt signaling MDM2 PTEN MTOR AKT3 PMC5789353__F1 Central pathway for fatty acid and cholesterol synthesis SCD LDLR ACLY FASN PMC5789353__F2 Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells ME1 HEL-S-26 CIC ACSS2 SLC25A1 GLUD1 HEL-S-32 GLS PMC7712612__F3 MIR22HG is involved in signaling pathways that affect cancer progression NOTCH2 SNAI1 SMAD2 SMAD4 CCND1 CDH2 STAT3 PMC9294223__F8 Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions CTSK PMC7479660__F4 Proposed mechanism by which losartan through Hsp70 inhibits the epithelial to mesenchymal transition (EMT) induced by angiotensin II in proximal tubule cells derived from SHR SMAD2 ARHA PMC6594147__F1 Dysregulated immune response in the primary mediastinal B‐cell lymphoma (PMBCL) tumour microenvironment CD58 MHC2TA IL13 CD2 CCR4 CCL17 RELB IL4 REL TNF SOCS1 FOXP3 PMC8247262__F5 Metabolic model of Lipomyces starkeyi for predicting lipogenesis potential from diverse low-cost substrates OMA1 CIT MAL PMC7775270__F4 Musicians in the intrinsic pathway of apoptosis—a large ensemble GSK3B TXNIP HRK BAX PMC6917616__F3 Metabolic and transcriptional adaption in tissue Treg cells HPGD AHR IL33 GATA3 FOXP3 PMC4449706__F5 Simultaneous Inference of Cancer Pathways and Tumor Progression from Cross-Sectional Mutation Data PIK3R1 BRAF DKFZp781B1423 CDKN2C EGFR SMAD2 SMAD4 PTEN RB1 CDKN2A FBXW7 FGFR2 SOX9 CDK6 HEL-S-26 NF1 FGFR1 ACVR2A ATM MDM2 CDK4 PDGFRA APC FGFR3 TCF7L2 PIK3C2G PIK3C2B PIK3CA PIK3R2 PMC2667705__F7 Regulation of hepatic HNF4A expression by insulin: involvement of SREBPs and proposed liver impairments LDLR HEL-S-70p HMGCR PMC7930983__F3 Integrin-dependent adhesion and tensile force mechanotransduction modulate cellular behavior ARHA RAC1 CDC42 PMC8318692__F2 Interleukin-17A (IL-17A): A silent amplifier of COVID-19 TH CCL20 IL8RB ACE2 IL17RC PMC1501017__F2 Different pathways involved in apoptosis CASP3 APAF1 CASP9 CAD FADD BAX PMC4885545__F5 Possible molecular targets whereby luteolin (Lut) inhibits the invasion of cancer cells HGF MDM2 VEGFA MTOR TG CDC42 PMC6538876__F1 Potential implication of proprotein convertase subtilisin/kexin type 9 (PCSK9) in amyloid B (AB) clearance in Alzheimer’s disease (AD) PCSK9 ABCA1 APOE CD36 PMC5983574__F1 Invasion-related molecules in oral squamous cell carcinoma CXCR3 FGFR1 HGF MMP2 EGFR DSG3 CXCL9 GAL CDH2 PMC4885545__F2 Luteolin (Lut) modulates cancer cell cycle progression IGF1R IGF1 GSK3B PSAP FLT3 MTOR IRS1 PMC6331581__F5 Predicted metabolic pathways of phylotypes NkOx7-01 and NkOx7-02 COPA C6 AMT PMC2699904__F8 Schematic showing inter-relationships of clustered genes associated with fatty acid, lipid and lipoprotein homeostasis based on differentially-expressed genes identified in lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice SQLE PEX19 PMVK ACAT1 FDFT1 ABCA1 STAT3 ACAT2 PMC2699904__F7 Inter-relationships of genes associated with apoptosis differentially expressed in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice TAF1 SET MARK1 XBP1 CLU BCL2L2 BIRC2 BCL2A1 BIRC3 BCL2 MCL1 JUN CASP8 FASN PMC8212477__F4 Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells ITPR2 PTGFR PRKCZ SOCS3 IFNGR2 EIF2AK2 TACR1 PTGER3 CCL2 CLDN23 MX1 STAT1 GRIN1 JUNB CGN IGSF5 LLGL2 IRF7 FOS HEL-S-79 ERBB3 TNF SLC25A4 ADCY8 ADAR PLN PLCB4 CHRM3 ITPKA TJP3 RYR3 JAK1 HTR2A IFIH1 MYLK P2RX3 PMC11459742__F4 Modeling ncRNA interactions with signalling pathways using GO data TBK1 CGAS EGFR IRF3 MYD88 PMC6730590__F2 Effects of mutant Kras in reprogramming amino acid metabolism ME1 GOT2 ATF4 ASNS EIF2A GLUD1 HEL-S-32 PMC6028121__F4 Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment APC CDC42 PMC3377831__F1 Biosynthesis and catabolism of melatonin CYP1B1 CYP2C19 CYP1A1 AAAS CYP1A2 AANAT PMC2679427__F1 Regulation of rat GSTA2 and NQO1 gene expression AHR NQO1 PMC3759481__F1 Simplified schematic shows the major intracellular signal transduction pathways that regulate the epithelial-to-mesenchymal transition (EMT) process in fibrotic kidneys HEL-S-28 APC GSK3B LRP5 LRP6 PMC6834155__F4 Non-genomic actions of thyroid hormone MTOR PFKP PMC6061156__F1 Ag processing and presentation pathways followed by CPP-Ag in dendritic cells CD80 PMC2921989__F1 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein TIGAR TSC2 IGF1 LIF CHMP4C MDM2 GLS2 PTEN MTOR BAX PMC4776187__F3 Modes of action of lipids in enterovirus replication TSC1 MTOR RHEB GABARAP PMC7522204__F5 In silico analysis indicating an inhibitory effect of Ambrisentan on PAR2 signaling pathway DKFZp686L0365 PGR EGFR SRC SYNGR2 PMC2921989__F2 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein PDK2 MDM2 RHEB BAX PMC3209254__F9 The multiple mechanisms by which Sox2 regulates the osteoblast lineage SOX2 APC GSK3B BMI1 PMC12155190__F1 NFKB signalling pathway leading to the expression of genes encoding inducible nitric oxide synthase (iNOS), interleukin-6 and adhesion molecules (i VCAM1 RELA PMC4070857__F2 The primary mechanisms through which vitamin D-regulated dendritic cells (DCs) and T-lymphocyte function.Notes: vitamin D precursors can be further processed to their active metabolite, 1,25(OH)2D3, in DCs and T lymphocytes NR1i1 CD40 CD80 CCL22 CYP27B1 IFNG PMC7415309__F7 Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/Beta-Catenin Axis HOXA1 PMC8693863__F7 ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion MYMK RAC1 MYOG PMC8065762__F5 Reductive stress in glutaminolysis HEL-S-26 GLS PMC6492945__F9 Schematic mechanism of Mac-1 regulation of human FOXP1 gene promoters and expression IRAK1 TRAF6 PMC12066304__F9 Genome-wide association study and transcriptomic analysis reveal the crucial role of sting1 in resistance to visceral white-nodules disease in Larimichthys polyactis TBK1 CGAS IRF7 IRF3 PMC4099309__F3 TNF and MAP kinase signaling pathways EEF2K EBP EEF2 EIF4E TNF PMC4099309__F2 TNF and MAP kinase signaling pathways EEF2K TRADD TNF MAP3K7IP1 TRAF2 FADD CDC42 PMC9386726__F6 Ubiquitin-ligase TRAF6 and TGFB type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells MMP2 SMAD2 MMP9 SMAD4 TRAF6 TF AURKB APPL1 PMC6463562__F6 Proposed scheme for PAHSA synthesis AIG1 MGST1 MGST3 ACLY HEL-S-128m ADTRP BAAT FASN PMC2477698__F1 Examples of the molecular mechanisms by which phytochemicals activate hormetic stress response pathways IGF1 NGF KEAP1 BDNF SIRT1 PMC8393382__F4 Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape ANGPTL3 TG PMC6753107__F1 Schematic diagram of the BPV system based on a two-species microbial consortium with constrained electron flow PC CYB NAPA PMC7795776__F5 Predicted relationship between expressed and regulated genes within integrin, paxillin, and RhoGDI signaling pathways, and the consequent activation of diseases and biological functions in elderly individuals with T2D HEL-S-28 SRC RHO HEL114 GIT2 ARF6 PXN CDC42 PMC10743408__F3 Mechanistic illustration of downregulation of interferon-responsive genes and JAK/STAT1/2 signaling pathway IFIT3 IFIT2 RSAD2 STAT2 IRF9 IFNAR2 IFNAR1 MX1 STAT1 ISG15 OAS2 ISG20 TYK2 JAK1 IRF-1 IFIT1 PMC12121985__F2 EGR transcription factors are essential in the functional regulation of T cells EGR1 EGR2 NAB2 GRB2 LAT PMC8619695__F4 Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders EIF2A XBP1 PMC7599628__F4 Initial immune response to any pathogen involves the activation of innate immunity TLR8 CGAS TLR5 IL16 TLR7 TLR4 TLR9 MYD88 TLR1 TLR10 MAVS PMC4422811__F2 Survival signaling vs EGF BAD FOXO4 FOXO3A EGFR BCL2 FOXO1 PMC6116115__F2 Polymerase-related genes identified using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis FEN1 LIG1 DNA2 PCNA PMC6993408__F6 LSS-triggered VEGF-ATOH8 signal axis mediates CRC m-CTCs survival ATOH8 HK2 PMC4256275__F11 RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities TBX1 ALDH1A3 FGF3 PMC7528506__F1 Homologues recombinant DNA repair system PALB2 RNF8 USP21 ATM BRCA2 RAD50 RAD51 H2AX MRE11A BRCA1 PMC6506535__F6 T helper cell differentiation pathway of MAIT cells in comparison with conventional T cells TH IL21R TGFBR1 TGFBR2 IL23R FOXP3 BCL6 STAT4 CD40 IL2RA CD80 IL-21 TGFBR3 GATA3 ICOS STAT3 PMC2908764__F3 Molecular cues controlling the pathway choices at the Drosophila and vertebrate midline KIT SEMA3B PMC8650508__F6 Salvianolic acid B targets mortalin and inhibits the migration and invasion of hepatocellular carcinoma via the RECK/STAT3 pathway MMP2 RECK MMP9 CDH2 STAT3 PMC6506535__F5 Natural killer cell signaling pathway of MAIT cells in comparison with conventional T cells LCK ZAP70 GRB2 LAT PMC6506535__F4 Role of macrophage, fibroblast and endothelial cell pathways in MAIT cells SOCS3 RELA IL17RA MYD88 TNF IL17RC LTBR SOCS1 STAT3 PMC6873406__F10 Non small cell lung cancer pathway circuit EGF BAD RASSF1 ERBB2 EGFR GRB2 CCND1 JAK3 PTEN STAT3 PMC10454700__F4 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells IGF1 RUNX2 INS IL6 DLX5 MAP3K7IP1 CDC42 PMC10454700__F3 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells BMP2 LRP5 HDAC1 PMC3861057__F8 Transcriptional changes in the WNT signaling pathway of E11.5 Sost–/–; Sostdc1–/– limbs CSNK1D RUNX2 CTBP1 SOST WNT7A GSK3B MYC SOX1 RYK TCF12 DKK1 MTOR DKK2 CSNK1G1 CDK6 CCND2 CCND1 CSNK1A1 AXIN2 DKK3 APC LRP5 MAP3K7 CD44 LRP6 SOSTDC1 ARHA DVL1 NLK TSC2 LEF1 NFATC2 TSC1 GIG8 WNT3A GJA1 AXIN1 BCL9 TCF4 CDC42 PMC4148086__F1 Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands CIP2A MDM2 PPP2R1A EIF4E COIL FOXO1 PMC12154233__F5 FSL-1 protects against radiation-induced damage through the TLR signaling pathway TLR8 TLR5 TLR9 MYD88 PMC3345303__F2 Neural and Cellular Mechanisms of Fear and Extinction Memory Formation HEL-S-30 ARC MTOR BDNF PMC3977151__F1 GOLGI IN COPPER HOMEOSTASIS: A VIEW FROM THE MEMBRANE TRAFFICKING FIELD ATP7B COX17 ATP7A ATOX1 CCS PMC7144730__F5 EVO downregulates HGF-induced c-Met/Src/STAT3 phosphorylation and causes apoptosis through blocking the c-Met signaling pathway HGF SRC STAT3 PMC11591922__F3 Mechanisms by which fasting or fasting-mimicking diets kill cancer cells in solid tumors ULK1 IGF1R IGF1 ATG101 MTOR FOXO1 SIRT3 PMC6873406__F13 Non small cell lung cancer pathway logic circuit with miRNA EGF ERBB2 GRB2 PTEN PMC6599195__F3 Signaling pathway downstream of TLR4 receptor in platelets with related cellular events and their regulatory miRNAs* CD14 VASP TLR4 GC TRAF6 IRAK4 MYD88 SNAP23 TIRAP PMC4720884__F8 Hypothetical model of the signaling pathway through which MIF is involved in ConA-induced autophagic cell death of hepatoma cells BNIP3 STAT3 PMC5775265__F4 Differential effects of HBZ on the Jun family proteins RPS25 JUND JUNB SP1 PMC7415235__F2 Key pathways involved in foam cell formation regulated by microRNA NLRP3 ABCG1 TRAF6 MYD88 CD36 PMC10631767__F2 Associations between CCA, TAMs and TANs IL10 VEGFA IL11 OSM STAT3 PMC10631767__F1 Interactions between CAFs and CCA cells PDGFD VEGFC HGF CXCR4 EGFR VEGFA HBEGF STAT3 PMC2713346__F1 Crz1 enters the nucleus in short stochastic bursts lasting about 2 min after undergoing dephosphorylation in the cytoplasm by the calcium-activated phosphatase calcineurin (Cn) (, ) NFATC2 NFATC4 NFATC1 REL NFATC3 DYRK1A PMC5857600__F5 Alterations in the mammalian Hippo signaling pathway alter FLNA phosphorylation MOB2 DCHS1 LATS1 LATS2 FAT4 PMC6295143__F2 TREM2 molecular signaling in microglia, initiating phagocytosis and microglial survival or modulating proinflammatory response, is not well characterized so only validated components are displayed TLR4 SYK PMC8486294__F7 CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion CXCL5 TRO IL8RB HEL113 PMC4107458__F1 Neutrophil derived S100a8/S100a9 protein potentially contributing hypertensive cardiac fibrosis induced by Ang II TLR4 MPO S100A8 S100A9 PMC9267440__F1 Identification of Genetic Variations in the NAD-Related Pathways for Patients with Major Depressive Disorder: A Case-Control Study in Taiwan NAPRT HAAO NAMPT HEL-S-90n KYNU KMO AFMID ALDH8A1 NRK PMC5412052__F6 IPA generated pathway prediction for the NRF2-mediated oxidative stress response in the small intestine EPHX1 FTH1 FTL HEL-S-107 UBB TXN BACH1 AOX1 NFKBIA HEL-S-94n ATF4 GPX2 CCT7 HEL-75 PPIB VCP JUN CLPP PMC6309361__F2 Effects of hemolysis on the monocyte/macrophage compartment DOCK8 SPIC BACH1 CDC42 PMC5412052__F5 Combined gene expression and predicted activation information for the mTOR pathway in the heart and small intestine PTEN RHO EIF4E RPSA RHEB INSR TSC2 TSC1 PC ELF3 SREBF2 RAF1 EIF4B PMC4975578__F2 Immunopathogenesis and Therapeutic Approaches in Pediatric Celiac Disease TH IL15 MICA JAK3 IFNG PMC6056039__F1 Calcineurin pathway in T cells and amplification of NFATc1/A MAF ITK NFATC1 FOS ZAP70 IL2 LAT PMC4463189__F1 Targeting cancer with kinase inhibitors KIT BRAF ROCK1 CSK RIPK3 CTLA4 MTOR MAP4K1 CSF1R PAK1 ATM CCND1 MERTK ATR PMC7866294__F1 Cellular ganglioside metabolism and structure of GD2 UGCG B4GALNT1 GAL B3GALT4 PMC4989157__F7 HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling WEE1 CDC25B ARID1A PMC7006128__F6 Innate immune system pathways showing Native American ancestry enrichment CD14 TLR9 CXCL10 IRAK4 LY96 MYD88 CCL3L3 ISG15 TLR4 IFNK LBP AIM2 CCL3 PMC4420468__F6 Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells LIF IRAK2 SH3GL1 TFRC IL6 SH3GLB2 FMO4 NEDD4 PLCB2 LEF1 ITGAV KPNA3 WNT7B TCF4 PMC11524014__F3 Carbon dots in anticancer immunotherapy HEL70 IL6 CD80 IL1B CRBN PMC8395128__F3 Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers RUNX2 ZNF521 PMC5698910__F1 Bile acid synthesis, signaling, and regulation in human liver CYP27A1 CH25H S1PR2 CYP46A1 CYP8B1 FGF19 CYP7B1 PMC9322659__F8 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) HSD17B12 CYP46A1 CYP8B1 CYP2R1 DHCR7 EBP AKR1D1 IDI1 ACAT2 PMC6158479__F2 Protective function of the calcium-sensing receptor against inflammation and carcinogenesis in the colon SOX2 CASR ROR2 PMC8455326__F4 Proposed gut–brain pathways mediating postoral sugar and fat appetition in mice BLM NTS PMC4632778__F10 Schema of osteogenic differentiation through the BMP signaling pathway and possible regulation by PARP activity RUNX2 BMP2 SMAD4 SMAD1 DKFZp781O1323 PMC4429004__F4 Functional prions in immune signaling NLRP3 MAVS NWD2 PMC9322659__F7 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) ACADVL ACLY SIRT1 FASN PMC5705453__F2 The role of ASK1 in endothelial cell TNF BAX PMC6452649__F7 Schematic model depicting RARA’s involvement in regulation of intracellular signaling, protein synthesis, and synaptic plasticity in postsynaptic neurons RARA TSC2 TSC1 RHEB PMC11547089__F10 Expression of genes involved in AsA biosynthesis in L INPP1 MIOX PMC9368002__F1 Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells GAD2 PNPLA3 MOG PHKA1 CXCL10 VEGFA KLF5 CYP7B1 S1PR3 RGS2 SERINC2 KDR WNT4 NGFR APP IGFBP2 CD40 ELOVL2 GREM2 CXCL12 NR1H3 ACSL3 C3orf57 PMC7482219__F1 Mesoderm patterning by a dynamic gradient of retinoic acid signalling CYP26A1 FGF4 NODAL FGF8 ALDH1A2 PMC11667808__F5 PI3K/AKT/mTOR, JAK/STAT3 and Rho pathway in optic nerve axon regeneration TSC2 TSC1 SOCS3 RHO PTEN EIF4E MTOR LINGO1 STAT3 PMC8631454__F8 Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice NLRP3 IL1B GSDMD PMC7911348__F1 TOR Signaling Pathway in Cardiac Aging and Heart Failure ULK1 EIF4E DEPTOR PMC9572851__F9 Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARA Signaling Pathway APOA4 PCK1 SLC27A2 ROCK1 ABCB11 OPTN CYP7A1 GSDMD INSR ABCB4 ACAT1 APEX1 PTK2B FABP5 APOA2 BAX ME1 FABP2 SLC27A4 EPHX1 YAP1 ADFP BDH1 PLIN4 FAF1 HEL-S-22 CASP3 HEL111 CPT1A SLC27A5 LSR FADD ASL STAT3 FABP1 PMC5515284__F7 CanProVar 2.0: an Updated Database of Human Cancer Proteome Variation CASP3 TSC2 BAD PERP ATM CDK2 MYC MDM2 PTEN ATR RFWD2 PMC7565917__F4 Hypothetical steps leading to the disassembly of NETs TLR4 TLR9 CLEC2D VWF TREX1 DNASE1L3 MYD88 PMC8507062__F3 Crucial role for the long non-coding RNA CASC11 in the pathogenesis of human cancers EIF4A3 PTEN EZH2 PMC5040984__F1 Patents and clinical trials involving the Wnt signaling pathway APC TNKS GPR49 PMC3930365__F6 Second ranked network of genes altered in the newborn lung at 24h post-O3 exposure MIS18BP1 TRO DAP ZW10 GPS2 CENPK BYSL CHADL GOLPH2 ESCO2 CENPN KNTC1 NUP155 PMC3930365__F5 Top ranked network of genes altered in the newborn lung at 24h post-O3 exposure FANCD2 APC TACC3 CENPE UHRF1 CDCA2 DBF4 BRCA1 MTHFD2 CDC45 CCNE1 STIL KNTC2 KIF15 MKI67 DLGAP5 PMC6363221__F9 Systems biology reveals how altered TGFB signalling with age reduces protection against pro-inflammatory stimuli C1QB ITGB4 TLR4 C1QA SMAD2 JAG2 EGFL7 CD84 TLR1 SMAD1 DKFZp781O1323 PMC7724003__F7 Nucleus accumbens-deep brain stimulation (NAc-DBS) alters neural excitability by modulating neuronal signaling pathways REN TES GAA PMC5992605__F7 Schematic model describing the molecular responses to SIL1 loss in skeletal muscles leading to myopathy IGF1R GADD45A MTOR SIL1 PMC8201103__F7 Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines ATF4 EIF2A XBP1 PHB2 BAX PMC8411238__F6 Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses TSC2 HIF1A MTOR PMC6521842__F9 A putative signaling pathway of ERK5/ankrd1 for promoting catecholamine biosynthesis TH ANKRD1 NGF PMC8334350__F2 Schematic models for combinatorial C. elegans and mammalian system studies regarding the role of insulin/IGF-1 signaling, mTOR pathway, and sirtuins ERCC1 EFL1 MTOR PMC5700831__F8 Depicting the possible molecular mechansims by which MitoQ prevents alcoholic liver disease through modulating ALDH2 posttranslational modifications TLR4 NOX4 ALDH2 PMC7118243__F2 Activation and inhibition pathways for ILC2s STAT1 NMU ADRB2 IL25 TNF VIP PMC2892252__F1 Host responses to Candida albicans: Th17 cells and mucosal candidiasis IL17A IL1B STAT3 PMC6053273__F5 The neurogenic activity of (2R,6R)-hydroxynorketamine TSC2 NGF EEF2 BCL2 BDNF PMC6498619__F3 Evolutionary conservation of the IIS pathway TSC2 TSC1 FOXO4 IGF1 FOXO3A F3 INS FOXO1 RHEB PMC3082642__F3 HBOT affects gene expression in the Nrf2 Pathway ATR JUN PMC5796148__F1 Change in the metabolism of adenosine signaling between the states of healthy and infected ADA PANX1 PMC6131422__F1 Substrates involved in caffeine biosynthesis pathways and its other related pathways catalysed by enzymes that were encoded by genes carrying the TAVs identified from this study TH GIP PMC2895966__F2 Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target CASP3 CASP9 TNF TRAF2 CASP8 FADD PMC7997388__F1 The human complement system HEL-S-62p CD59 C9 C4B_2 FH C7 C5AR2 C6 CR2 CP PMC6556902__F3 Significant pathways identified using Tied Diffusion through Interacting Events method, an approach that can extract the most likely set of interconnectors between two sets of nodes PDE4D IL21R IFNA21 IRAK1 CCL2 MYD88 IKZF3 IL1RL2 OSMR IFNG IL16 TIMELESS NPY TIMP3 HEL-S-44 RAD50 IL1RAPL1 NOS2 CSF2 CASP8 MMP10 IL1A IFNL3 IL1RN VEGFA ADRB2 TNF HLA-DRB1 IL23R THPO IL15 EDN1 TBX21 PDE4B NFKB2 PPP2CA BCL2 GH1 IL2RA IL11RA ERCC2 SLA2 IRAK3 MPL TGFB1 CSH2 HLA-G CSF3 IL9 IL1R2 IL1R1 IFNGR2 HLA-DQB1 IL12A CSF2RB IFNA7 IFNA6 IL18 SIGIRR IL2 CD2AP IL10 CD14 CAMK2D CCL11 IL13 MMP9 KIF3A IL24 PARP1 PRL CFTR HLA-DPB1 IL7 IL3 PRLR IL23A IL33 JAK3 TYK2 IL6ST IL-21 IL20 IL18RAP OSM SOCS1 IL18R1 PMC3117879__F2 Implications of Relationships between Human Diseases and Metabolic Subpathways PAH TERT PMC6556902__F2 Analysis of severe asthma differential expression gene signature in the context of STRING protein association network HEL2 SFN IL22RA1 BLM HEL-S-1 CRY2 IL1R2 RAPSN PTEN WNK4 MATK BMP4 FHOD1 CPXM1 NOG FYN IL18 PLXND1 ACVR2B BMP5 KCNN4 KHDRBS2 YWHAG IL1B NPHS2 PTK6 BMP6 SYT13 KRT73 MAP3K6 HEL-S-28 IL20RB HSD17B13 STAP2 CHEK1 CALM1 YWHAQ CLSPN KHDRBS1 MCM2 SEMA3E FLT3 ATR HEL-S-93 IL20 SMAD1 AGRN PMC6556902__F1 Examples of representations for contextualizing disease associated genes ALOXE3 GPX4 GPX1 LTC4S PNLIP IKZF3 BTK APEX1 GPX2 TGFBRAP1 HSD17B4 HLA-DMB PYCARD NCF2 PMC12002712__F1 Biosynthetic pathway of D-tocotrienol in Y HPD IDI1 IPP PMC3595017__F1 Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses TANK TRADD IRF7 IRF3 FADD MAVS PMC8397082__F1 Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects FOXC1 BMPR1A TBX1 PITX2 TGIF1 SMAD4 FOXC2 FOXE1 HAND2 CTDNEP1 PMC7553077__F2 Recent advances in engineering different immune cell types for immunotherapy applications CCR5 CD33 CDK5 PTEN LAG3 ADAM17 NTN1 ADORA2A HEL-S-171mP BACH2 PAX5 CD7 CD40 B2M IRF4 PMC3309939__F8 Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling PI3 PIKFYVE PMC8313992__F10 Acute TBK1/IKKE Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury TBK1 IL33 TMEM119 CSF1 CD68 IFNG PMC8353181__F3 Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease CXCR4 MSC CXCL12 PMC11007064__F6 Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNA production CGAS IRF3 CDKN2A GATA4 PMC7594023__F1 Pathway analysis map showing VEGF signaling via VEGFR-2 generic cascades MAPKAPK2 PLAUR COX1 ROCK1 PTGS2 MAPK3 VEGFA CREB1 ARHA CCL2 RAC1 HRAS NCK1 GRB2 SRC SHB MAPK1 JUN TCF4 CDC42 PMC4867603__F4 Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet ABHD5 ACACA PDHA1 ACSS2 ACLY FASN PMC6156233__F6 Graphical Abstract IL10 IL18 TLR4 GC RPE PMC8747665__F7 Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds COX2 BMP6 MMP2 BMP15 LDLR FSHR POR INSR PMC7032926__F9 Proposed model of TLR5-TLR4 interaction during environmental lung injury TLR5 TLR4 MYD88 PMC3932023__F2 Exosome secretion in a cancer cell model RAB5A RAB27A RAB9A RAB27B RAB13 PMC6449901__F4 Summary of genes involved in the glycolate production pathway DAP CIT MAL PMC3175442__F4 Map of cytoskeleton remodeling pathway (Genego Metacore, fragment) overlapped with quantile-normalized estimations of protein abundance LIMK2 LIMK1 HEL-S-28 GSK3B GRB2 MAPK1 HRAS PMC8593216__F6 APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells GEM ATR PCNA PMC3175442__F2 Map of pentose phosphate pathway (Genego Metacore) overlapped with quantile-normalized estimations of protein abundance RPIA HEL107 RPE PMC7202972__SF1 Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice GHR STAT5B PMC8018932__F8 Proposed model of mToxin effects in the brain of AD mice (with emphasis upon A7AChR function) BACE1 NACA2 NACA PMC2964177__F1 ErbB2 cellular signaling pathways and lapatinib mechanism of action ERBB2 PTEN MTOR PMC9095829__F8 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases TRPV4 ATF4 XBP1 PMC9510782__F6 Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein DOK3 TLR4 S100A8 MYD88 STAT3 PMC3488313__F4 Proposed mechanism of associated vWF activating GPIIb/IIIA VWF PLCG2 PMC4812578__F1 PI3K/AKT signaling pathway TSC1 MDM2 CCND1 PTEN MERTK RHEB PMC7190223__F1 Components of canonical hippo signaling pathway LATS1 LATS2 PMC3259514__F1 Different signaling pathways leading to the induction of virus stress-inducible genes (VSIGs) and interferon-stimulated genes (ISGs) TBK1 STAT1 STAT2 IRAK1 IRF9 ATF2 TRAF6 IRF3 IRAK4 JAK1 MAP3K7IP1 IRF-1 PMC6104630__F2 (B–catenin mediated) Wnt signaling pathway APC GSK3B SP5 PMC4168074__F1 Model proposed by Rakoff-Nahoum et al TLR4 MYD88 PMC7047286__F4 Tdh- and tRNA synthetases-derived origins of AI-3 analogs PMC5595144__F2 Dendritic cells (DC) can either activate adaptive immunity or tolerize T cells depending on their state of maturation BTLA LAG3 STAT3 PMC9471148__F2 An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors STAT1 NF1 KIT BRAF PDGFRA STAT2 MTOR STAT3 PMC4683003__F1 Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferi PMVK MVK IDI1 PMC7266663__F7 Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway SI NFATC1 TRAF6 PMC8220689__F6 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers PMC8220689__F5 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers CTNNBIP1 PMC3378042__F2 Implications of Protein Post-translational Modifications in IBD NUB1 TLR4 IL6 FADD PMC8529925__F1 Molecular testing for colorectal cancer: Clinical applications EGF EGFR PTEN MTOR PMC11676931__F5 Nerelimomab alleviates capsaicin-induced acute lung injury by inhibiting the TNF signaling pathway and apoptosis in vivo and in vitro; (some of the material is from Figdraw https://www TNF BAX PMC7997318__F6 Nrf2 pathway in different liver diseases MAF KEAP1 PMC9139203__F1 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer PALB2 ATM BRCA2 RAD50 RAD51 MRE11A BRCA1 PMC5576943__F2 Complement activation pathways and allograft immunity HEL-S-62p MASP1 APC CR2 C1S PMC11120013__F2 Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer EGF KEAP1 HBEGF NQO1 CP PMC11120013__F4 CP-derived RONS promote cancer cell autophagy and death by activating the mitogen-activated protein kinase (MAPK) family signalling pathways BCL2 DKFZp686F0183 CP BAX DFNA5 PMC7767423__F1 Fatty acid mobilization and utilization in skeletal muscle during endurance exercise LPL CPT2 PMC5499156__F1 Proteins that interact directly or indirectly with mGlu1/5 receptors and mediate receptor signalling PI3 TAMALIN MTOR PMC6005849__F7 PI3K–AKT pathway perturbation in response to treatment of interleukin (IL)-6 stimulated osteoblasts with resolvin E1 (RvE1) BAD MEI1 EBP PIR PTEN RAC1 EIF4E MTOR RHEB TSC2 BCR MDM2 RAF1 EIF4B RBL2 ELL CD19 PMC10999569__F3 PIAS family in cancer: from basic mechanisms to clinical applications PIAS1 TNF PMC9170726__F8 Fas/FasL regulating mROS and IFNG production after IL-12/IL-18 stimulation STAT4 PMC5535714__F3 Redox regulation of Wnt/Beta-catenin signaling pathway and lipid peroxidation APC GSK3B CCND1 RAC1 PMC8466912__F3 Inhibition of Cellular and Animal Inflammatory Disease Models by NFKB Inhibitor DHMEQ TRAF6 TRAF2 IL1B PMC9220248__F2 Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity PLG IL33 IL25 TSLP PMC9356782__F6 Renshen Baidu Powder Attenuated Intestinal Inflammation and Apoptosis in Ulcerative Colitis Rats through the Inhibition of PI3K/AKT/NFKB Signaling Pathway TSC2 BAD CD37 HEL-S-11 PTEN RBL2 CD19 PMC8624111__F10 Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity MYC PIGS PTEN MTOR RFWD2 TSC2 CASP3 ATM APAF1 CDK2 CD2 MDM2 CASP9 ATR PMC8468056__F6 GPR30 Activation by 17Beta-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor A Protein Expression by Inducing Its Release from a Complex Formed with KEAP1 KEAP1 EGFR SRC MTOR PMC3623255__F3 Metabolic pathways in the periplasm and the cytoplasm GAD2 PPL PGP PMC3623255__F2 Mass isotopomer labeling measurements of intracellular metabolites (red bars, after 8.0 h in growth phase I; green bars, after 14.25 h in growth phase II) arranged by pathways: fractional abundance over mass in context of the metabolic network GNE PGP TNLG7C RPE GLA MAL PMC4350260__F1 NFKB and STAT3 in Glioblastoma: Therapeutic Targets Coming of Age ING4 PIN1 SOCS3 TRADD VEGFA JAK1 EZH2 MTOR STAT3 PMC6315409__F3 Biosynthetic pathway for very-long-chain fatty acids (VLCFA), the dicarboxylic acid 20:4 (DCA 20:4), and the very-long-chain dicarboxylic acid 28:4 (VLDCA 28:4) ELOVL1 ELOVL4 ELOVL5 ELOVL3 ELOVL2 PMC4091980__F1 Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain BAD MDM2 CASP9 PTEN MTOR PMC6158396__F3 HMGB1 signaling pathway in cerebrovascular disease HMGB1 IL1B PMC4280670__F3 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication ATF4 EIF2A PMC7009407__F7 Schematic and simplified diagram of some salient features of AHR signalling pathways Black solid arrows depict the canonical pathway, dashed arrows alternative pathways, and the red solid arrow an example of their intersection COX2 AHRR APP PMC9139203__F8 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer PALB2 ATM BRCA2 RAD51 BRCA1 PMC3241972__F1 TOR in the immune system TSC2 RICTOR TSC1 EIF4E MTOR DEPTOR RHEB MLST8 PMC7793734__F7 Hypothesized mechanism by which endothelial cells promote docetaxel resistance of prostate cancer cells PC ERG FGF2 MTOR ELL PMC8750110__F5 Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success? CGAS ENPP1 IRF3 TNF PMC5517472__F3 Overview of the metabolism of hepatic methylamine HEL-S-61p TG PEMT PMC7475009__F1 Based on WGCNA, we explored the correlations among gene modules and all possible variables, with particular interest in those related to age CD72 IGF1 BCR PRMT3 GC CD22 LYN INS CD19 STAT3 PMC4177745__F9 GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line GID4 STAR PMC2816169__F6 Prokineticin (PROK1) induction of regulator of calcineurin 1 isoform 4 (RCAN1-4) and interleukin (IL-11) RCAN3 RCAN1 PROKR1 PROK1 PMC10311568__F2 Research progress of sophoridine’s pharmacological activities and its molecular mechanism: an updated review CDK2 PTEN NR3B3 PMC7868826__F4 EGF induced A20 expression via the MEK1/MSK1/p-p65 (Ser276) signaling pathway EGF TNF HEL-S-162eP PMC4280670__F1 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication PDGFRA EGFR GRB2 TRAF6 PTEN PMC4807283__F1 CerS are central enzymes in the sphingolipid metabolism pathway CERS3 LASS1 CERS5 KDSR CERS2 CERS6 PMC4344863__F1 Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis LRAT CRABP2 RBP4 RDH10 DHRS3 ALDH1A2 PMC6044101__F6 Spleen regulatory networks CHST11 EGF BTRC NPTXR ASB1 MYC GIP IFNG POLE2 FBLN7 SLC25A21 BSDC1 ZNF786 ARPP19 KRTAP10-3 RRM2 SCG3 HTT KCTD7 ARL4A ZPR1 SLC6A20 CNN2 TMIE SLC16A10 HCTP4 YOD1 ABCB9 BCL2 SBNO2 HRK PMC7558103__F1 The nicotinamide adenine dinucleotide (NAD) metabolism NAPRT NAMPT NMNAT1 NMNAT2 NMNAT3 PMC4496332__F2 Dendritic spine dysgenesis in Autism Related Disorders TSC2 UBE3A TSC1 ARC PTEN EIF4E RCAN1 MTOR BDNF RHEB PMC10674583__F1 Nrf2-keap1/ARE signaling pathway MAF KEAP1 NQO1 PMC4631372__F4 Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation EPHA3 OXCT1 MAP2K4 ITGA4 CACNB4 RDX PPM1B FGF9 FGFR1 MAP4K3 PFN2 PDHA1 L2HGDH HEL70 AACS CSK FGF2 NLK IKBKB CACNA1G PDGFC ITGA6 NRP1 CXCR4 HSPA1A RPS6KA2 PMC4445567__F5 Upregulated and downregulated genes in the cell cycle pathway after expansion in serum-free medium CDK2 SMAD4 CDC2 PCNA MYT1 PMC5681673__F4 UV-induced H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway RNF168 RNF8 HUWE1 PMC4366432__F1 Epidermal growth factor receptor pathway BRAF EGFR MTOR PMC7517358__F3 Genetic networks associated with genes differentially expressed between radiosensitive and radioresistant gastric cancer (GC) cell lines MXD1 FOXO4 HBE1 ITGB6 SEC23A HIF1A CD74 ZDHHC11 S100P TIMP3 PRG2 MDM2 FOSB GYPC GABRA2 EZH2 ENC1 HSD17B4 RPS20 TNFSF8 NAB2 OLFM4 LCN2 RRAD IRF3 CRK S100B CDKN2B TNFRSF8 BIK CCNG1 ADAM10 IL27RA CBLC UBE2L6 MXI1 FHL1 TLE3 PTPRK RAB20 IL11 WTAP NOD2 EPHB6 CCND2 HOXD11 TFPI2 KYNU NOD1 HOXD10 SNURF SFRP1 TMSB15B MAGEA11 PCDH10 HMGB1 ANTXR2 CFB CLDN1 PCTK1 HEL-S-53e NTS PDPN CAMK2G COXFA4L3 ID3 PTPN22 FCGR3A GIG8 HNF4A MYF5 IL3 PMAIP1 FHL2 CSRP2 KLF9 ACSL3 PMC7403995__F7 Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes BTK PI3 FYN LYN VWF SYK PLCG2 RAC1 LAT PMC5810588__F1 Reciprocity in ROS and autophagic signaling HMGB1 ULK1 ATG16L1 ATG12 ATG3 PTEN ATG10 OPTN DKFZp686F0183 PI3 TFEB ATM TXNIP CAMKK2 PMC2903791__F11 Cell signaling model for the regulation of glucose metabolism in hepatocytes by taurocholate EGFR SRC IRS1 PMC4631976__F1 Death resistance signaling in cancer cells RIPK1 BAD TRADD RIPK3 FADD MLKL BAX PMC9266893__F2 Iron, Neuroinflammation and Neurodegeneration ERFE BMP6 EPO HFE IL6 TFR2 PMC2950751__F9 Summary schematic illustrating the adaptations of select genes of the IGF-1/PI3K/Akt pathway involved in protein synthesis and degradation analyzed in the plantaris muscle SMAD2 MTOR IRS1 PMC4131167__F7 Differential dependency network presented over the KEGG] apoptosis pathway BAD TRADD ATM IL3 TRAF2 FADD PMC4131167__F6 Rewiring of apoptosis pathway in breast cancer patients with and without recurrence CASP3 PIK3R5 BAD PPP3R1 NFKB1 NTRK1 CSF2RB TNF IRAK3 IL1B BAX PMC8247606__F2 Biological underpinnings of therapeutic resistance in pancreatic cancer ME1 KEAP1 PMC6291713__F8 JAK2 overexpression alleviates C2C12 myoblasts I/R injury through the AKT and ERK1/2 pathway BAD BCL2 TYK2 MTOR IFNG STAT3 PMC5997144__F2 P-Rex1 acts as a convergence point for pro-oncogenic/metastatic pathways HRG CXCR4 HIF1A PREX1 PMC11663741__F7 Protein-protein interaction networks were analyzed among differentially abundant proteins PIK3CD MAPK8 PLCG2 CLEC4E WAS CCR1 DKFZp686L0365 CFD VWF MASP2 PRF1 HMCN2 IRF4 ITGA1 CFB RRAS2 ITGB1 CD79B GNG12 C1QB CARD9 NFATC2 PPP3R1 LYN ZAP70 CTNND1 FLT3 DOCK2 C1QC SERPINF2 STAT3 PMC2736328__F2 Transcriptional regulation of cytokine function in airway smooth muscle cells BCL10 TRADD TRAF5 TRAF3 SRC SYK IRAK4 TNF TRAF2 PMC4966762__F1 Signaling pathways activated by ET-1 in cancer COX2 COX1 HEL-S-28 EGFR GSK3B SRC ARHA PMC8764238__F3 Molecular Mechanism of Puerarin Against Diabetes and its Complications GSK3B MDM2 IRS1 FOXO1 BAX PMC10546030__F2 Methionine biosynthesis and metabolism: Diagram of metabolic pathway showing aspartate family pathway, metabolism of methionine and cysteine biosynthesis DHPS PMC6266939__F1 Main components of the Hippo pathway and the current Hippo-targeted inhibitors discussed in this review AMOT HEL-S-28 RHO CDC2 PMC8307460__F1 RelB and Neuroinflammation TRAF3 LTB RELB IL1B PMC10756743__F6 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation CD47 ADAMTS2 ADAMTS12 ADAMTS5 MMP2 THBS2 ADAMTSL1 ITGB1 PMC10756743__F5 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation THBS2 PMC4017641__F1 O-glycan biosynthesis/human version pathway GALNT5 GCNT3 GALNT7 GALNT4 GALNT3 GALNT1 GCNT2 PMC9082421__F4 Transcriptome and iTRAQ-Based Proteome Reveal the Molecular Mechanism of Intestinal Injury Induced by Weaning Ewe's Milk in Lambs OLR1 SLC48A1 MS4A1 ADFP TFRC DBI AOX1 ACSL5 SCD RDH12 CD22 CYP1A1 CR2 EHHADH FABP1 PMC8430316__F2 Molecular mechanisms contributing to the formation of cancer-associated adipocytes PDE3B SOCS3 MMP11 MYC STAT3 PMC4466442__F2 Pathologic role of TCR, BCR and TH17-induced MALT-1 in demyelination and the inhibition of this signaling pathway by A20 BCL10 BCR CYLD RELB PMC3834519__F10 FXR/NR1H4 gene CCR5 CXCL1 TNIP3 CXCL5 MMP9 MAPK14 CCL2 TNF CD8A CXCL13 MAPK1 CXCL12 IRAK3 NR1H4 CXCL11 PMC8764238__F1 Molecular Mechanism of Puerarin Against Diabetes and its Complications FOXO1 STAT3 PMC7277336__F1 Signaling cascade of insulin-like growth factor 1 (IGF-1) and its potential impacts in metabolism, its interactions with transforming growth factor B3 (TGFB3) and the biological functions of the IGF1, IGFBP2 and TGFß3 genes BAD IGF1R IGF1 FOXO3A TGFBR1 GSK3B MTOR IRS1 PMC8430873__F3 Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC) BAD CDC2 BAX PMC9357648__F8 lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2‐mediated PI3K/AKT pathway in glioma GSK3B SP1 MTOR BAX PIK3R2 PMC11922625__F2 Interaction of tau and DRN CDK5 CDK3 CSA2 PMC6122628__F2 HUWE1-mediated proliferation/differentiation MAX ATOH1 MYC SHH HUWE1 PMC3312987__F2 Commonly mutated pathways in glioblastoma NF1 CDK4 PTEN CDK6 PMC4315039__F2 Functional components of the GDR pathway ATM ATR PMC9115588__F5 Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities FYN GSK3B LRP5 CCND1 LRP6 STAT3 PMC3863542__F1 UPR signaling pathways in mammalian cells ATF4 EIF2A XBP1 PMC3812807__F7 PKCE ACTIVATION PROMOTES FGF-2 EXOCYTOSIS AND INDUCES ENDOTHELIAL CELL PROLIFERATION AND SPROUTING FGFR1 KDR STAT3 PMC4186798__F6 Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression CCNB1 BCL2 CDK4 MTOR BAX PMC3183286__F2 The role of sphingosine kinase localization on substrate utilization and delivery of S1P to specific sites for secretion or loading of intracellular effectors TRADD HDAC2 TRAF2 HDAC1 PMC5166441__F1 Complement system HEL-S-62p CD59 C9 C4B_2 FH CRP C7 C5AR2 C6 C4A PMC10987323__F10 MtETC in M2 macrophage polarization F2 PFKFB1 MTOR CD36 GLS PMC6076394__F7 Network obtained from genes sharing different pathways EGF NFATC1 ACTN1 HEL-S-15 E2F5 TNF SLIT2 FCGR3B CRK PDPK1 RHOD LCP2 FYN GIG8 GAB2 FZD2 PTPN11 APC2 CSF2RA PMC3666507__F4 Cross-talk between muscle (pink) and tendon (dark grey) cells in Drosophila RYK PMC7488355__F3 Association between Alcohol Use Disorder and manifestation of Alzheimer’s disease (AD) GSK3B CDK5 MTOR PMC4900635__F7 MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway MACC1 TWIST1 GC VEGFA PMC6714139__F2 LPS/TLR4 signalling pathway TBK1 CD14 TLR4 IRF7 TRAF3 TRAF6 IRF3 IL6 MYD88 MTOR TIRAP PMC8261291__F1 Targeting Bruton’s Tyrosine Kinase in CLL BTK BCR BASH LYN SYK PLCG2 MTOR CD79A CD19 PMC8882816__F3 Innate Antiviral Immune Response by Porcine Enteric Coronavirus TBK1 STAT2 IRF9 IRF3 MYD88 TLR3 TLR8 TLR7 TLR4 TYK2 IRF-1 MAVS STAT3 PMC6961549__F1 Crosstalk between hypoxia and the unfolded protein response (UPR) pathways ATF4 VHL SIAH2 HIF1A MTOR XBP1 PMC6531879__F4 Mapping of hits in the MAPK signaling pathway CD14 EGF NGF MOS DAO FLNA EGFR TRAF6 NLK MAX GRB2 ECSIT RAF1 BDNF TRAF2 JUN PMC5715835__F3 Molecular interactions and outside versus inside cell identity CDX2 TEAD4 GATA3 PMC4269892__F6 Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer SMG1 MARVELD1 PMC11779893__F6 Possible mechanism of AMLN diet and exercise on mitochondrial homeostasis during MASLD development FGF21 ATF4 LONP1 CLPP PMC8903056__F3 SIRT6 and epigenome maintenance CGAS HP SIRT6 WRN PMC10608708__F7 Mapping of the top targets in the PI3K-AKT signaling pathway BAD MYC PTEN EIF4E MTOR RHEB RXRA TSC2 BCR GRB2 SYK EIF4B RBL2 CD19 PMC4774216__F1 RhoA/Rho kinase in spinal cord injury ROCK2 HEL-S-62p ROCK1 ARHA PTEN LPA LINGO1 PMC8623046__F9 Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway FST KEAP1 BAX PMC9252758__F2 Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy TSC2 RNF168 TSC1 RHEB PMC4274867__F1 KEGG pathway of 470 DEGs downregulated in the frontal cortex of AD identified by RNA-Seq data analysis MLNR GPR78 GHSR GIPR GRPR PRLHR CALCR LPA SCTR TACR2 LTB4R PRL GCGR LEP TSHR OXTR PRLR GHR MC2R LEPR FSHR LHCGR PMC4691146__F2 Processes affecting TOB1 levels and diverse mechanisms underlying TOB1 tumor suppression activity RPS6KA1 APC GSK3B TOB1 SMAD4 CCND1 PTEN AURKA BAX PMC4405319__F2 Toll-like receptor 4 (TLR4) signalling TBK1 CD14 TLR4 IRAK1 LBP TRAF6 IRF3 MYD88 TIRAP MAL PMC6454697__F5 The relationship between zinc finger proteins and hippo pathway in cancers MZF1 PMC7812690__F4 Cardiotoxic effects of angiogenesis inhibitors BAD MTOR BAX PMC10526871__F3 Nuclear Estrogen Receptors in Prostate Cancer: From Genes to Function EGF IGF1 SRC JUN PMC11491369__F3 Mitochondria in embryonic heart development MFN1 PINK1 MFN2 FIS1 OPA1 PMC6269824__F1 Biosynthetic pathway of sialic acids and feasible implementations of artificial precursors GNE NANS NANP PMC6555789__F9 Summary and integration of the main results ALOX15B SLC6A9 ALOX12 PMC7058019__F2 Development of a CRISPR/Cas9n-based tool for metabolic engineering of Pseudomonas putida for ferulic acid-to-polyhydroxyalkanoate bioconversion TES C1S FADD HEL-S-5 PMC6615111__F3 Molecular regulators and signalling mechanisms involved in the activation of astrocytes CNTF LIF GFAP RGMA OLIG2 STAT3 PMC4324900__F4 Identification of Genetic Determinants of the Sexual Dimorphism in CNS Autoimmunity AHI-1 PTPRK SHE SYK THEMIS PMC9027032__F9 Differential Nanoscale Topography Dedicates Osteocyte-Manipulated Osteogenesis via Regulation of the TGFB Signaling Pathway EP300 RUNX2 COL1A1 PMC7491975__F2 Different regulation of angiogenesis and vessel stability between VEGF and angiopoietin signaling, relating to regorafenib action SRC ARHA PMC6693777__F6 Transcriptome analysis of the molecular mechanism underlying immunity- and reproduction trade-off in Locusta migratoria infected by Micrococcus luteus EGF INS GOPC PTEN IL6 INSR ATM CDK2 MDM2 FOXG1 KLF2 BNIP3 SKP2 STAT3 PMC3394120__F4 Cytoskeleton remodeling signaling, an example of a differentially regulated pathway in the motor cortex of SALS PIN1 WASF1 GSK3B CDK5 NEF3 NEFH VLDLR FYN CDK5R1 DCTN1 HEL-S-77 DAB1 NEFL PMC8002322__F2 Targeted therapies directed at cell cycle and DNA damage repair pathways ATM SSB CCND1 ATR BRCA1 PMC4926301__F8 Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts TBK1 IL18 TLR4 MYD88 IL4 PMC3223722__F1 Glycogen synthase kinase 3 modulates the function of key signaling proteins in the wnt pathway APC MYC PMC11855587__F1 Endogenous Specialized Proresolving Mediators in Mast Cells and Their Involvement in Inflammation and Resolution FADS2 ELOVL5 FADS1 ELOVL2 PMC5916807__F7 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types HERC2 BTRC APC MDC1 MYC HEL-S-92n PTEN RBX1 RAD18 BRCA1 RNF168 CDC20 RNF8 CDC27 APC2 SKP2 TERT PMC7333221__F1 Origin of B-cell-associated malignant tumors and the anti-tumor mechanisms of HDAC6 inhibitors PDC FOXO1 PMC7348171__F2 Functions of NgBR include regulating cholesterol trafficking via directly binding to NPC2, hepatic FFA and TG metabolism through inhibiting LXRA transcription in an AMPKA‐dependent pathway GSK3B MDM2 VEGFA RAF1 NPC2 TG FASN PMC7133748__F2 Nectin adhesion pathway (positive regulation of JNK cascade) was more active in the nonresponder tumors (upper panel) than in the responder tumors (lower panel) SRC FARP2 CDC42 PMC10151556__F1 An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review NLRP3 TXNIP IL1B FOXO1 PMC5314727__F4 Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma dik KIF23 SPC24 CDKN3 UBL3 RALA ABHD2 OSMR RGL3 STIL CENPA PLS1 PLAUR SHOX2 PPL CENPE ZMYND11 PCP4 E2F7 NEDD9 SHCBP1 GTSE1 TRIP13 SHISA2 HGF UCK2 HEL-S-134P ANXA3 NUF2 RRM2 CXADR CAV2 SYNE4 MKI67 GPRASP1 RALGPS1 MAL CLIC3 HEL-S-34 LTBP1 EPB41L5 SEC63 AURKA CCBE1 MRTO4 BCAT1 GALNT12 PKP4 CCNB2 KIF20A INF2 CENPN ASS1 MME PYGL PMC3890716__F2 Schematic for the putative biosynthetic pathways of three major classes of active compounds in I DDC STS CAD IPP AMT CCR1 PMC11868730__F3 Drug-active components-common targets-pathways network diagram F10 PPP3CA ALB MYC ALOX5 KCNC2 FGFR4 DRD1 SLPI PTGS1 HMOX1 MMP2 MAP4 SLC2A2 CASP9 GABRA2 CHRM2 NOS2 CASP8 MMP10 PON2 CYP2B6 MAP3K7 ADRB2 TNF NCAM1 HAS2 CHRNA2 HEL-S-22 VEGFC SLC6A3 MUC4 CHRM1 F7 BCL2 ADRA1A HTR2A TGFB1 PSMD11 F2R HSP90AB1 PDE3A ICAM2 DPP4 PTEN ACHE SLC6A2 TOP2A CYP1A2 INSR AHR DIO1 F3 XDH CYP1A1 CDC2 JUN SELE PAQR6 BAX PRSS1 CYP1B1 OPRM1 PTGS2 PTPN22 IKBKB CASP3 GSTM2 CHRM4 ADRA1B AHSA1 CHRM3 CYP3A4 GJA1 RELA STAT4 SCN5A PPARG GABRA3 PMC5431130__F4 Representative schematic of the proposed TRIF contribution to NFKB-dependent TNFA promoter activation CD14 TLR4 LBP TRAF6 MYD88 MAL PMC8883581__F6 Overexpression of MUC1 Induces Non-Canonical TGFB Signaling in Pancreatic Ductal Adenocarcinoma MUC1 SMAD2 SMAD4 PMC6883365__F2 Network visualization of pathways enriched with genes influencing non-platinum-based treatment response in oral cancer.Hexagon shapes are genes CTBP2 NRF1 HDAC3 MED10 TBCD GSK3B GNG7 SOX1 PLCG2 UBB USP11 SOX7 CCNE1 ASH2L SRY PSMD7 FYN VBP1 SOX13 APC LRP6 FZD4 FZD5 CALM1 WNT3 ARL2 NR1C2 ARNT2 TERT TMED5 PSMD9 RYK ACOT12 GNGT1 FZD1 PYGO1 AHR MEN1 GNAZ PSME4 NFYB PSMB8 CCNE2 SIN3B PS1TP5BP1 GNG12 IKBKB CARD11 NFKBIA CREBBP NFATC2 LEF1 EP300 ACADL CPT1A LYN SYK NPAS2 PPARG GNB2 TBCB PORCN DKK1 PDPK1 MED23 MED17 RSPO3 FBXW9 HEL-S-278 WNT4 TLE4 FZD2 NFYC SRC PFDN2 SNX3 PSMB9 VPS29 VPS35 TUBB MED19 PSMB2 HRAS MED22 CCNO GNG3 KMT2C TCP1 PAK1 HELZ2 RORA PSMD2 DCAF7 TLE2 GNB4 TAB3 IKBKG GNG13 HADHB TRRAP GNG10 LEO1 DKK2 TEAD2 PYGO2 UBC GNG4 RSPO1 MTF1 SOX3 GNG2 GNG11 PPIC RGS11 SOX2 RNF43 TNKS LONP2 WIF1 DVL3 NR1C1 PSMD3 GNAT2 RAF1 TBCC KIFC3 PMC6883365__F1 Network visualization of pathways enriched with genes influencing platinum-based treatment response in oral cancer.Hexagon shapes are genes CTBP2 HDAC3 TBCD SOST GSK3B GNG7 SOX1 PLCG2 UBB SOX4 ASH2L SRY PSMD7 FYN FBXW4 SOX13 PSMD10 SIN3A SP1 HEL-S-71 APC LRP5 NCOA6 GNGT2 FZD4 DKK4 CCT4 GNAT1 MED16 ARL2 SMURF2 NR1C2 PSMD6 GNB1 ARNT2 TERT HEL-S-91n TBCE TBL1X RYK MED31 FZD1 PYGO1 MED8 GNAI1 AHR MED13L RGS1 SFRP1 GNAZ NFYB NFYA MED11 AHRR MAP3K7IP1 MED21 PS1TP5BP1 GNG12 IKBKB NFKBIA CREBBP NFATC2 LEF1 CPT1A LYN SYK RSPO4 SOX6 NPAS2 FZD8 MED12 GNB2 CDK19 TBCB PORCN DKK1 RNF146 MED23 MED17 RSPO3 FZD2 CCT7 NFYC SRC PFDN2 SNX3 PSMB9 RGS6 WLS CCS ZNRF3 TUBB MED19 PSMB2 HRAS MED9 KIF13A MED22 GNG3 TCP1 PAK1 HELZ2 MED28 MED13 HEL-S-100n RORA PSMD2 PSMD1 TLE2 GNB4 TAB3 CHUK BTRC GNG13 GNB5 TRRAP GNG10 LEO1 CCNC ESRRA TEAD2 UBC GNB3 GNG4 MTF1 TRFP SOX3 GNG2 GNG11 FRAT2 RGS11 TUBA3E SOX2 CBY1 SKP1 TBCA TNKS LONP2 WIF1 DVL3 NR1C1 DVL1 PSMD3 IXL RELA RAF1 HEL-S-93 TBCC PMC6567518__F8 Summary of the function of OD-Exo in the odontogenic differentiation of DPSCs through TGFB1/smads signaling pathway via the transfer of mircoRNAs SMAD2 SMAD4 LTBP1 TGFB1 PMC9066101__F3 Smad3 Signatures in Renal Inflammation and Fibrosis CDK2 SMAD2 CRP SMAD4 CDK4 PMC9066101__F2 Smad3 Signatures in Renal Inflammation and Fibrosis SMAD2 CRP SMAD4 FOXP3 PMC9066101__F1 Smad3 Signatures in Renal Inflammation and Fibrosis SMAD2 CRP SMAD4 CDK9 SIRT1 PMC316396__F7 Axial and appendicular cartilage SHH GATA4 PAX1 PMC6318995__F7 Characterization of complex transporter-mediated model of carbon allocation and energy supply for oil synthesis in developing P PC ABCB9 LPA MAL PMC7017275__F2 Identified downstream targets of YB-1 in gynecological cancer CXCR4 EGFR PMC7017275__F1 Simplistic model of the mTOR signaling pathway in cervical cancer EGFR MYC EIF4H EIF4E DEPTOR SGK1 PMC9361070__F2 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer HEL-S-102 STEAP3 KEAP1 HMOX1 PMC8829599__F5 Renal calcium and magnesium handling in Gitelman syndrome TRPM6 CNNM2 TRPM7 UMOD PMC9361070__F1 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer GPX4 LPCAT3 FACL4 SLC3A2 GLUD1 PMC8831326__F7 Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart SMAD2 SMAD4 MSTN PMC9553959__F2 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways MYC PTEN MTOR CDK6 RFWD2 CASP3 AIFM2 IGF1 PERP CD2 MDM2 CASP9 CDK4 ATR PMC8804886__F5 mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion SOX2 BMP2 APC GSK3B SMAD6 PTEN MTOR ID1 ID3 RHEB RICTOR TSC1 GIG8 BMPR1A SMAD1 DKFZp781O1323 PMC9553959__F4 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways CTSL CANX CTSS HEL-S-99n TNF IFNG TAPBP PMC9553959__F3 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways TSC2 BAD CD37 BCR PTEN RAC1 GAL IRS1 BRCA1 RBL2 RHEB CD19 PMC10377929__F7 Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3B in Cultured Human Dermal Papilla Cells APC LRP5 LRP6 PMC5270332__F8 Schematic diagram depicting the KRT19-mediated regulation of NUMB expression, NOTCH signaling pathway and cancer/cancer stem-like cells (CSLC) properties in KRT19-overexpressing breast cancer cells MAML1 NUMB KRT19 NOTCH1 CCND1 RAC1 HRAS HES1 PMC3427211__F3 Microbes-induced EMT at the crossroad of inflammation and cancer TBK1 TLR5 TLR9 TRAF6 IRF3 MYD88 TLR1 NOD2 TLR3 TLR8 IL16 TLR7 TLR4 NOD1 AIM2 TIRAP PMC6454697__F4 miRNAs and Hippo pathway DGCR8 DROSHA LATS1 LATS2 PMC9554999__F3 Comparison of meiotic transcriptomes of three maize inbreds with different origins reveals differences in cell cycle and recombination ELF2 SEL1L CASP12 ATP6 ATF4 SVIP WFS1 SEC63 BAX SEC62 PMC6916696__F1 The diverse regulatory mechanisms of circRNAs in GC PTEN CDH2 MTOR PMC8197527__F6 Carcinogenesis of Triple-Negative Breast Cancer and Sex Steroid Hormones PMC7993665__F7 Signaling pathway diagram NLRP3 TXNIP IL1B GSDMD PMC11844283__F7 Schematic model illustrating the mechanisms by which DSF/Cu activates innate immune signaling pathway to enhance anti-tumor immunity and potentiate therapeutic responses to PD-1 checkpoint blockade (created with BioRender TBK1 CGAS CXCL10 IRF3 CCL5 IFNG PMC9322395__F1 Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma NR1i1 CYP2R1 DHCR7 PMC7203474__F2 Iron recycled and released by TAMs sustains the cancer progression SCARA5 LCN2 TF CP PMC5352101__F3 Type I insulin-like growth factor receptor signaling in hematological malignancies TSC2 BAD TSC1 GSK3B GRB2 PTEN IRS1 FOXO1 PMC7203474__F3 Copper addiction of cancer cells could prevent the pro-inflammatory phenotype of macrophages CCND1 PMC3560469__F2 Angiotensins in the RAS DAP ACE2 PMC9372561__F1 Gut microbiota dysbiosis: The potential mechanisms by which alcohol disrupts gut and brain functions TLR4 APC IL1B PMC4897699__F7 Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury CD44 CD74 PMC4430931__F1 Signaling pathway of the extrinsic factors, glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) RET BCL6B ID4 NANOS2 FGF2 GDNF LHX1 ETV5 FOXO1 PMC8340306__F1 CGAS-STING signalling in liver diseases TBK1 STAT1 CGAS STAT2 IRF3 TYK2 JAK1 IFNAR1 PMC8626953__F1 To explore immune synergistic function of Quercetin in inhibiting breast cancer cells STAT1 WAS PMC4417456__F4 Signaling pathways deregulated in HPV-associated HNSCC EGFR TP63 TRAF3 MYC FGFR3 PTEN RB1 DDR2 CDKN2A FGFR2 HLA-B HLA-A BIRC2 ERBB2 CCND1 B2M EPHA2 CASP8 FADD LTBR PMC8699920__F1 Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer EGFR GRB2 STAT3 PMC9181319__F1 Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth Muscles in Health and Disease TRAF5 RUNX2 NFATC1 TRAF6 TRAF2 PMC11855193__F2 ApoA-I regulates blood sugar PDX1 EBP IRS1 PMC7397746__F1 Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids CEPT1 LPA PSD PMC3584916__F3 Signaling pathway of IFIT family genes TLR4 TLR9 IRF7 IRF3 MYD88 TLR3 PMC6520733__F6 Proposed model for ANXA2 regulation of AKT activation HEL-S-2a EGF ANXA2 EGFR PTEN PMC9359989__F6 Ingenuity pathway analysis of synaptosomal miRNAs in AD RELA ENDOV PMC7481617__F1 Estrogen receptor (ER) and pan-HER signaling inhibition has synergistic activity and leads to gene expression changes associated with good prognosis in non-small cell lung cancer (NSCLC) FOXC1 CXXC5 EGF PGR FOS AREG EGFR MIA JUN GRB7 PMC3584916__F4 Antiviral and immune regulated function of IFIT family genes TBK1 IFIT3 IFIT2 ELF3 IRF3 IFIT5 MAVS BAX IFIT1 PMC7658690__F7 Relationship between target and pathway network IKBKG FOS PTGS2 MMP9 RELA EGFR GSK3B TNF JUN PMC9303342__F2 Co‐option of stress mechanisms in the origin of evolutionary novelties PTGER2 PGR PTGER4 PMC8984190__F2 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer GOLPH3 SRC PKD1 GPRC5A CDC42 PMC8984190__F1 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer PLCB3 SRC LTK GPRC5A PMC9589207__F2 Non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review ERBB4 ERBB2 NRG1 MTOR PMC2756316__F5 Proposed model for the interaction between PyVmT and IR or IGF-IR PLCG1 GRB2 SRC PMC9661723__F2 Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay SMG9 SMG8 UPF2 SMG1 DHX34 SMG6 SGA56M SMG5 PMC6286812__F2 NOD-like receptor signaling pathway from KEGG shown with drugs, targets and known mechanism of action (→ denotes activation, ---> and ---> denote indirect effect and — denotes binding/association) TRAF6 TRIP6 CARD6 CCL2 MAP3K7IP1 NOD2 PSTPIP1 CARD9 NOD1 ERBIN CASP8 IL1B CASP5 TAB3 PMC8776082__F1 Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases MUC1 SOCS3 IL22RA1 IL20RB FLG IL24 TYK2 JAK1 S100A7 PMC5854489__F3 Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma NAMPT NMNAT1 NMNAT2 NMNAT3 NADSYN1 PMC6042731__F3 Cell cycle in LNCaP cells after NETD PLK1 ORC6 SMAD2 SMAD4 DBF4 CDK7 CDC45 CDC6 CDK2 MDM2 RAD21 PCNA SKP2 MYT1 PMC5217522__F2 Possible explanation for opposing Notch-1 effects on NSCLC cells.Notes: Overexpression of constitutively active proteins is susceptible to experimental artifacts, the extent of which can be greatly modulated by environmental conditions IGF1R IGF1 IGF2 PMC8320333__F8 A New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma CDK4 MTOR CDK6 PMC11311579__F1 Metabolic pathway of vitamin D and the role of VDR (Vitamin D Receptor) in signaling based on Płomiński et al CYP27A1 NR1i1 CYP2R1 DHCR7 CYP11A1 PMC6413278__F7 The proposed mechanisms for the inhibitory effects of MS-275 on osteogenesis in VICs GSK3B LRP5 LRP6 ARHA ROR2 PMC4218909__F2 Cartoons of PAR1 activation by thrombin in the membrane lipid-rafts of endothelial cells when EPCR is free or occupied by its natural ligand PC ARHA RAC1 PMC7308527__F1 Tryptophan (Trp)→ kynurenine (Kyn) metabolic pathway HEL-S-90n KYNU KMO PMC6657359__F7 Model for Hand2-Dependent Mechanisms That Regulate iPM Formation by GHMT TBX18 SHOX2 NKX2-5 TBX3 HAND2 ISL1 HCN4 PMC4218909__F1 Cartoons of protein C activation and APC signaling in the membrane lipid-rafts of endothelial cells PC APC RAC1 PMC5217522__F1 Simplified schematic of Notch signaling.Notes: In mammalian cells, Notch receptors are synthesized in the endoplasmic reticulum (ER) IGF1R MYC FURIN MTOR PMC7254680__F1 Scheme for the overall GPI-APs biosynthetic pathway, structural remodeling and transport PIGF PGAP1 PIGO PGAP2 PGAP3 PIGW PGAP6 PIGK DPM2 HEL-S-5 GPAA1 PIGC PIGH PIGM PIGL PMC3225910__F1 Signaling network connecting Rheb and AMPK TSC1 PTEN RHEB PMC4811470__F2 Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer SGMS1 SCD FASN PMC4157363__F1 Determinants of Breast Cancer Progression HEL-S-62p HOXD10 LIF PTEN PMC3641099__F1 Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer MAPK11 CPD PMC5384880__F5 Differential expression of proteins in the nucleus accumbens generates specific network interactomes in ENT1−/− mice SQSTM1 SLC18A3 TRAF6 PENK CDC34 PAG1 PCSK2 PDYN FYN BCLAF1 SLC1A2 EIF2A KCNK2 ChAT DNPH1 OSBP2 NRGN SLC29A1 OTOF VDAC3 THY1 PCSK1N FLOT2 GJA1 HEL-S-42 PCSK1 PMC5384880__F4 Differential expression of proteins in the dorsal hippocampus generates specific network interactomes in ENT1−/− mice GAD2 INA L1CAM PPP3CA MBP SLC32A1 GAS7 NEF3 NEFH SLC6A11 AKAP7 PYGM ARL15 VAPB NCAM2 WASF1 HPCAL1 MPP2 BASP1 COXFA4 VAMP1 GRIA2 ARPC5 S100B CACNG8 NDUFB4 PPP3R1 ARPC2 WIPF3 NEFL PMC5406854__F2 Ways of targeting MYC and its transcriptional output using specific signaling pathway, BET bromodomain, and complex inhibitors in MYC-dependent malignancies MAX GSK3B TEF MYC FBXW7 AURKA POLI BRD4 PMC12250682__F7 Multifaceted antitumour mechanisms of Astragalus polysaccharides (APS) in liver cancer CCND1 CDH2 BAX PMC7924210__F2 Simplified mechanism of the classical endocannabinoid ligand signaling pathway NAPEPLD FAAH PTPN22 PMC6718562__F6 Role of IL-1 cytokine family members in the immunological history of the hepatocarcinoma NLRP3 CDA AREG IL33 IFNG PMC7814617__F7 Schematic model for the mechanism of action of anemoside B4 in the treatment of colitis TLR4 S100A9 BAX PMC8182917__F1 Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment FOXA1 ERG GATA3 PMC5666320__F6 Model of Rho/F-actin pathway repression by EWS-FLI1 via MRTFB/YAP-1/TEAD transcriptional perturbation MRTFB TPM1 CALD1 TAGLN PMC5582828__F2 Mechanisms by which fusion genes promote kinase activation and cell survival and opportunities for therapeutic intervention BCR CRLF2 BAX PMC7772217__F3 Role of the inflammasome complex in modulating immune responses in a Toxoplasma gondii infection NLRP3 GBP1 CARD9 NLRP1 SYK CASP8 PMC4503882__F4 Postulated signaling pathway for MMF through binding to HCAR2 NAMPT HCAR2 IL1B SIRT1 CAMKK2 PMC11675326__F19 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation FH APP MCU NOD2 FADD PMC11675326__F18 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation BAD CD37 PTEN RAC1 EIF4E MTOR IRS1 RHEB TSC2 TSC1 BCR MDM2 GRB2 SYK EIF4B RBL2 CD19 PMC5411695__F3 Hedgehog (Hh) signal transduction in the primary cilium SUFU PTCH1 GPR161 GLI3 EVC SHH SMO PMC11675326__F17 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation CD14 TRADD FLNA TRAF6 MYD88 TNF NLK MAX GRB2 CYC1 JUND RAN TRAF2 MEF2C PMC3236573__F3 Ovarian cancer ascites-mediated protection from TRAIL-induced apoptosis FADD BAX PMC6212884__F1 Canonical TGFB/SMAD signaling pathway SMAD2 TGFBR1 SMAD4 PMC9035937__F4 Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease VCAM1 VEGFA PMC11742290__F2 LGR5 in the WNT/Beta-catenin pathway ZNRF3 RNF43 APC MYC LRP5 CCND1 LRP6 GPR49 PMC11647666__F7 Proteome analysis after Mg treatment for t = 2 days COX7A2L ATP1B1 BTD B4GALT5 AKR1C1 CPT2 PIGV HIF1A PYGM HEL-S-26 PTS NANS NMNAT1 COL16A1 APIP PGM2L1 IMPDH1 C9orf72 HEXA GCLC AMBRA1 COL5A2 PLCB1 NAPRT TNC PPP1CC HSPG2 STT3A AGPAT3 DHFR SGMS2 HEL107 PNP MARS2 COL3A1 ATP5PO CA13 COL1A1 ATP5F1D CITED2 ALDH5A1 NDUFA5 UROD COL1A2 NDUFS5 GABARAP ITGA1 RAB7B CYB IDH3B SDSL GANC NDUFA2 SDC4 SMPD1 SUCLA2 BNIP3 COL4A1 PMC5754510__F1 Important growth factors and cellular signalling pathways involved in tumourigenesis and angiogenesis of NETs BAD GAS1 PTEN EIF4E IRS1 CDK6 TSC2 ATM CDK2 MDM2 SMO CDC2 CDK3 PMC3760066__F2 Two TLR signaling pathways TBK1 CD14 IRF7 IRAK1 TRAF6 IRF3 IRAK4 MYD88 MAL PMC10452677__F1 Relevance network of genes, transcription factors, small molecules, functional classes, miRNA, and biological processes that are shared between DMD and HMB (based on Pathway Studio Web Mammalian) IL10 CSF3 MYF6 MSTN IL6 TNF FOXO1 IFNG LEP IGF1 TRIM63 TGFB1 SIRT1 BAX PMC3393470__F1 Chemical structures of PSI-352938 and its potential metabolites and the proposed metabolic pathway of PSI-352938 activation CYP3A4 ADA GUK1 PMC11675326__F21 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation RHOD BAD GSKIP FRS2 GRB2 SHE TRAF6 RAC1 BDNF CRK CDC42 BAX PMC3587990__F4 Interaction of marine compounds on survival and apoptotic signaling molecules BAD MTOR BAX PMC3587990__F3 Pathway of apoptosis BAD BCL2 BAX PMC3348077__F7 Signaling pathway for the cytoprotective effect of STI571 in TRAIL-treated colon cancer cells TRADD TRAF2 FADD PMC3587990__F2 Scheme of survival signaling cascade by receptor tyrosine kinases via PI3K/AKT mediated survival BAD PDK2 MDM2 PTEN MTOR PMC11675326__F20 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation TRPV4 ATM MCU PTEN ATR RHEB HEL-S-69p PMC6542064__F7 Temporal dependence of G2/M DNA replication checkpoint mechanism on the G1/S transition mechanism CDKN1B CCNH RB1 DBF4 TFDP1 PKMYT1 CDC45 CCNE1 MCM3 CDKN1A CDC6 WEE1 CDK2 CCNB2 ORC1L CDC2 SKP2 PMC3587990__F1 Scheme of PI3K/AKT mediated antiapoptotic regulations at the mitochondria BAD MTOR BAX PMC5384880__F8 Physiological development-functions associated with the dorsal hippocampus and nucleus accumbens of ENT1−/− mice GAD2 L1CAM MARCKS HDAC3 DTNBP1 SLC25A25 CSTB MAOA RGS14 FYN PDE10A MLSN2 ChAT WASF1 CACNA2D3 NRGN SLC29A1 VDAC3 KIF13A GRIA2 SDC3 THY1 KCNJ3 SLC6A3 PPP3R1 ABAT SLC18A2 ADAM22 NRXN1 ADAM10 ABCA1 CPLX2 NEFL GPR37L1 SLC7A11 SLC18A3 SLC32A1 SHANK3 NRXN2 ACHE SMARCD3 SLC1A2 CD47 ATP1B2 SLC10A4 CLCN6 SLC6A9 SNAP25 DNAJC3 SLC17A6 DBI GJA1 PTPRE MLYCD MAPK8IP1 CERS6 PMC5748601__F1 TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis TLR4 IRAK1 IRAK2 TRAF3 LBP TRAF6 IRF3 IRAK4 MYD88 TIRAP PMC2861144__F1 Novel targets for the treatment of autosomal dominant polycystic kidney disease TSC2 EGF TSC1 IGF1 MYC SRC MTOR JUN RHEB CFTR PMC2861144__F2 Novel targets for the treatment of autosomal dominant polycystic kidney disease TSC2 TSC1 IGF1 MTOR IRS1 RHEB PMC4951239__F2 Functional role of autophagy in gastric cancer MTOR SIRT1 PMC266780__F7 Scheme to illustrate the separate functions and regulation of conventional nonsarcomeric myosin IIA and myosin IIB NGF RHO LPA CP PMC9179868__F1 Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis HK3 HEL-S-30 KEAP1 DERL3 EGFR EAF2 HEL-S-133P HK2 HEL-S-162eP PMC4429169__F1 Network uncovered using IPA PRKCI SBSN MARCKS STAC CLEC4A HBB UGT8 JUNB NTRK2 DDIT4 PMC4038542__F1 Complement activation and effector functions C9 C4B_2 C7 C6 PMC7423983__F3 Function of SIK1 in tumorigenesis LEF1 HDAC3 TWIST1 HEL-S-11 ZEB2 IL6 ID1 SIK1 TCF4 PMC7423983__F2 Roles of SIKs in the regulation of glucose, lipid metabolism and inflammation are illustrated IL10 TLR4 PCK1 TRAF6 IRS1 PMC7097452__F2 Prognostic and predictive enrichment in sepsis CX3CR1 LAT2 CXCL8 DCSTAMP RGS13 PRIM1 G0S2 RGS1 FFAR2 CKS2 HRG MAFF CD300C EMR3 TNF CCRL2 HTR4 DDIT4 NINJ1 IL36RN CEACAM8 TREM1 TGFB1 TGFBI CD24 PMC5453186__F3 Clostridium difficile infection NLRP3 TLR5 TLR4 NOD1 IL1R1 MYD88 IL1B PMC6537480__F2 Signaling pathway mediating cardiovascular protection of OT MFN2 MOS CAD PMC10939994__F2 Correlation of HDAC7 and three signaling pathways BAD APC HDAC7 MDM2 PTEN STAT3 PMC7179196__F1 PPARA and PPARG signal cascade following their activation by endogenous or synthetic ligands TNF BDNF PBR PMC11886387__F3 McCullough protocol: Base spike detoxification TLR4 PLG ACE2 PMC8908152__F6 Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma DAO MAX TRADD CYC1 TNF PMC6103720__F4 Autophagy contributes to integrin recycling and degradation ULK1 TBC1D14 RAB25 SRC UBB PMC8892718__F3 Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions AHR CCL26 IL33 TSLP PMC3154366__F4 c-Myc regulates the rate limiting steps at the entry into glycolysis ALDOB HK3 FBP2 PGM3 FBP1 GCK PFKL PFKM HEL-S-87p PFKP HK2 PMC9028333__F1 Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities BAD SOX2 ATF4 TRIB3 MTOR ID1 PMC7791970__F7 Schema of the signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production NLRP3 IL16 TLR4 MYD88 PMC12048151__F1 How two mutations associated with developmental defects impact BMP4 secretion FAM20C BMP7 BMP4 PMC6757435__F9 Signaling pathway proposed in this study TIAM1 RAC1 PMC8038777__F2 Granulocytes role in CRC CXCL1 CCL11 EPO CCL4 S100A9 IL25 TNF IFNG CCL15 CCL24 ARG1 IL1B CCL3 PMC9669439__F2 Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma IDO1 BCAT1 BCAT2 ACLY ARF6 HEL-S-133P GLUD1 HK2 RAB11B FASN GLS PMC4980741__F2 Signaling pathways regulated by SHP-2 in the gastrointestinal tract EGF HGF IRS1 STAT3 PMC8744322__F7 Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/Beta-catenin/Gamma-cystathionase pathway CTH HMGB1 GSK3B PMC6580874__F3 Simplified schematic of the PI3K pathway, which highlights the common targets for small molecule inhibitors RICTOR BRCA2 MDM2 PTEN MTOR IRS1 PMC7507442__F1 DNA damage and the programmed cell death pathway (apoptosis) induced by radiotherapy RAD1 ATM MDM2 SSB BCL2 ATR MRE11A FADD BAX PMC3215281__F7 Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease FEN1 ERCC1 XPA OGG1 PCNA PMC9371512__F6 The Bushen Huoxue formula in the treatment of osteoarthritis based on network pharmacology-molecular targets CHUK MPO BRAF THBD MYC CXCL8 CCL2 MMP3 KDR NR1i1 MMP2 SRC JUN SELE CTSL IL10 FOS PTGS2 MMP9 CXCL10 CD44 ADRB2 TNF HPSE HEL-S-130P NR1C1 CASP3 RET HEL111 MMP12 ERBB2 RELA BCL2 PPARG CYCS PMC2195911__F10 A molecular mechanism whereby cAMP inhibits T cell function CSK LCK PMC3485057__F4 Increased Biomass Yield of Lactococcus lactis by Reduced Overconsumption of Amino Acids and Increased Catalytic Activities of Enzymes AIP PMC3765067__F2 Map of molecular interactions involving GADD45 proteins and cell signaling pathways generated using Ingenuity Pathway Analysis software (IPA) NGF ATF2 TNFRSF1A MYC GRB2 RAD51 BRCA1 PCNA PMC4036354__F1 Cross-talk between Two Signaling Pathways Drives Aggressive Late-stage Breast Cancer♦ NEGR1 SMAD2 SMAD4 PMC11575037__F16 Selected subnetwork of the differential network for Artery Tibial tissue in Atherosclerosis LEP HGF LPL MOK FABP5 TNFRSF11B HEL-S-104 PMC11575037__F14 Figure shows selected subnetwork of the differential network for Artery Coronary tissue in Atherosclerosis MPO DPP4 LPL MOK FABP5 PPARG NR1C1 PMC8600921__F1 Cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies NLRP3 HMGB1 TLR4 GZMA CD40 MYD88 AIM2 IL1B GSDMB GSDMD PMC6204373__F2 TRAFs in canonical and non-canonical NFKB signaling pathways TRAF5 TRAF1 TRAF3 RELB TRAF6 TRAF2 PMC9357337__F4 ELIMINATOR: essentiality analysis using multisystem networks and integer programming WNT3A FZD7 FZD1 PMC6204373__F1 Role of TRAFs in TCR-, costimulatory receptor-, and cytokine receptor-associated signaling pathways controlling TFH differentiation TBK1 IL21R TRAF3 CXCR5 TRAF6 BCL6 STAT1 TRAF5 TRAF1 IL7R TRAF2 ICOS STAT3 PMC9357337__F3 ELIMINATOR: essentiality analysis using multisystem networks and integer programming WNT3A FZD7 FZD1 PMC4539521__F6 Changes in gene expression and MAPK signaling pathways in Cgasg1Δ and Cghal9Δ strains SLN FUS CDC42 PMC9514850__F9 Differential metabolic pathway and reaction analysis HTT PAGE2 PMC8702253__F8 Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking IL10 EREG EGF EGFR SOST VEGFA IL6 HRAS IRS1 VEGFC KDR PTPN11 GRB2 RAF1 IL4 SOS1 IL10RA VEGFB TGFA STAT3 PMC5654621__F1 Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer’s disease BACE1 SORL1 BIN1 APP PICALM PMC6173469__F1 Genomic mechanisms of immune evasion in colorectal cancer: from discovery to clinical practice APC B2M PMC6030495__F6 EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival EGF EGFR SRC STAT3 PMC7985675__F2 Retortamonads from vertebrate hosts share features of anaerobic metabolism and pre-adaptations to parasitism with diplomonads AIP FES MRO TF PMC3346698__F8 One of the KEGG prostate cancer pathways (b) the paths detected by our method EGFR BCL2 CDC37 IRF2 PXN SP3 PMC4958958__F1 PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy HEL-S-182mP MTR DHFR MTRR TYMS MTHFD1 TPMT PACSIN2 PMC3346698__F5 The main chain path of pheromone response pathway (b) the assembly paths detected by Scott et al FAR1 HEL60 CDC42 PMC4944657__F6 Antagonizing integrin beta3 increases immune suppression in cancer STAT1 TLR4 SYK PMC3318612__F8 Summary model of rAdV-sensing cascades in RAW 264.7 cell line TLR9 IRF7 DDX41 IRF3 MYD88 AIM2 POLI PMC3292304__F4 Gene functional association networks for selected pathways in p53 dataset BAD NCBP2 SFN BCL2L1 MPHOSPH9 SPN MPHOSPH6 BAG1 TNFSF6 APAF1 SRPK1 CASP9 BTG2 BAX MAPKAPK2 HSPB2 TNF MPHOSPH10 PS1TP5BP1 BCL6 CASP3 HEL-S-102 YWHAQ IGF1 IL3 BIK BTG1 BCL2 MCL1 CYCS PMC5187845__F2 Acceleration of osteoblast differentiation through the p53–Akt–FoxO pathway GADD45A PTEN EIF4E PMC4432802__F1 Schematic representation of the principal pathways involved in glucose catabolism summarizing recent findings discussed in the Mini Review (red boxes) IFNG HEL-S-162eP PMC5685326__F1 PD-1 in T-cell activation, exhaustion, and effector function APC CD80 PMC5892988__F1 BMP receptor signaling pathway SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC3606422__F1 Methotrexate mode of action RFC1 ABCC3 GGH DHFR ABCC1 ADA TYMS ABCG2 FPGS ABCC2 ABCB1 PMC6953796__F4 Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34 PDC PC CIT PMC5892988__F3 Roles of the BMP system in steroidogenesis and mitogenesis in growing follicles BMP6 BMP2 BMP15 BMP7 FSHR STAR PMC6087588__F2 Proposed signaling mechanisms of adiponectin in prevention of ischemic stroke ADIPOR1 ADIPOR2 VCAM1 NR1C1 PMC5971020__F1 RIG-I-like receptor signaling pathway PELO TANK TRADD DERA CYLD IL2 TNF FADD PMC4939324__F3 Anti-inflammatory mechanisms of MFG-E8 in a LPS-TLR4 signaling pathway CD14 TLR4 SOCS3 STAT3 PMC8286283__F3 Cellular roles of ER-phagy and the contributions of metazoan ER-phagy receptors CCPG1 TEX264 ATL3 SEC62 PMC8249453__F4 Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer’s disease BAD ATP5G1 NDUFV2 NDUFB9 NDUFA6 NDUFB2 CALML4 MCU COXFA4 UQCRFS1 ZNF183 NDUFB1 NDUFA12 LPL CASP9 CYCS PMC4905711__F1 Role of Nrf2 and Autophagy in Acute Lung Injury MAF GCLM KEAP1 RBX1 PMC8536203__F10 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping IKBKG CHUK PPP3CA GSK3B PLCG2 CD81 DAPP1 BTK PIK3AP1 BASH LILRB2 GC FCGR2B CD19 NFATC1 FOS RAC1 CD79A IKBKB CARD11 NFKBIB MAP2K1 CD72 PRKCB CD22 LYN GRB2 RAF1 VAV2 PMC3886588__F1 Targeting the Th17 pathway IL21R IL16 IL23R IL17RC IL1B PMC5811630__F7 Iron starvation responses DCD DUT LPA PNP PMC3921548__F1 Overview of arachidonic acid metabolism LTA COX1 TES LTB PMC2713571__F1 Proposed cuticle pigmentation and sclerotization metabolic pathway in T TH DDC CP PMC4682646__F1 Complement activation, regulation, and molecular basis for complement‐related diseases CD59 LTA C4B_2 CD46 VTN FH CRP CD55 C4A MAVS PMC8511314__F9 Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase EGFR LPA MTOR LPAR3 PMC7410257__F7 Kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media LAT2 FOS LCK EGFR GRB2 JAK3 TNF HRAS MTOR JUN PMC7322393__F1 Zoledronic acid (ZA) acts as immunostimulant and endosomal disruptor of dendritic cell in SARS-CoV-2 infection CD1A CD83 CD80 IPP PMC9317349__F1 Present Status, Challenges, and Prospects of Dihydromyricetin in the Battle against Cancer MDM2 NOX4 PTEN SP1 MTOR STAT3 BAX PMC4155175__F3 mGluR1-TRPC3 signaling at parallel fiber-Purkinje cell synapses TRPC3 RHO PMC8861314__F6 Asiatic Acid Attenuates Osteoporotic Bone Loss in Ovariectomized Mice Through Inhibiting NF-kappaB/MAPK/ Protein Kinase B Signaling Pathway CTSK NFATC1 DCSTAMP ACP5 PMC5880173__F1 Bone morphogenetic protein (BMP) pathway and potential strategies for therapeutic modulation SMAD4 SMAD1 DKFZp781O1323 PMC3825489__F3 Cross talk between the coagulation and complement system HEL-S-62p PLG MASP2 TF PMC5622528__F9 Hexokinases link DJ-1 to the PINK1/parkin pathway IGF1R GSK3B PTEN IRS1 HK2 PMC5038858__F3 The Notch pathway in ovarian (A) clear cell carcinoma ES2 and (B) serous carcinoma OVCAR3 cells following exposure to vorinostat CS HEY2 HEL-S-11 NOTCH1 PMC10528301__F3 An Overview of CD133 as a Functional Unit of Prognosis and Treatment Resistance in Glioblastoma TSC2 TSC1 SFN PTGS2 MDM2 CCND1 BCL2 CDC37 RAF1 EIF4E EIF4EBP1 PMC9105159__F1 Wnt/Beta-catenin pathway modulation via DKK1 inhibition LEF1 APC GSK3B LRP5 LRP6 DKK1 PMC5744151__F2 Restriction factors block multiple stages in the influenza virus life cycle ZMPSTE24 IFITM3 BST2 B4GALNT2 IFITM2 MOV10 CCND3 RNASEL ISG15 RNASE1 OAS3 PKP2 TRIM32 ISG20 RIN2 TRIM56 TM9SF2 PMC11596795__F5 Metabolic pathway and relative abundance of key genes of DAMO bacteria (a–c) and DAMO archaea (d–f), with predicted metabolic function as recorded in KEGG MTR HEL107 PMC5733031__F1 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram-negative bacteria TLR4 SOCS3 IRF3 MYD88 SOCS1 MAL PMC10807637__F6 HDAC inhibitors target IRS4 to enhance anti-AR therapy in AR-positive triple-negative breast cancer IRS4 CCND1 MTOR PMC5733031__F2 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram positive bacteria LTA SOCS3 IRAK4 MYD88 TLR1 SOCS1 MAL PMC8019794__F3 Macroautophagy pathway and signaling ULK1 ATG16L1 ATG12 ATG3 ATG10 MTOR ATG14 DKFZp686F0183 PMC6093783__F31 The biosynthetic pathway of polyoxin 292 POLE POLK POLG POLL POLM POLI PMC4339403__F3 Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding HEL-S-101 XBP1 PMC4132813__F8 Model depicting the role of the PP1A signaling pathway in coordinating the activation of BRD4 and P-TEFb for inducible gene expression HEXIM1 CDK9 BRD4 PMC9319031__F2 Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health H1-0 CCND1 CDK4 MTOR SOX6 PCNA PMC5340233__F4 SIN3A and SIN3B differentially regulate breast cancer metastasis SOX21 TRADD CCND2 PMC8124706__F1 Targeting BRAF and RAS in Colorectal Cancer EGFR MYC GRB2 SOS1 JUN PMC5889941__F1 Alterations in glucose and glutamine metabolism contribute to tumor growth and proliferation HEL-S-133P PHGDH GLS PMC6247426__F1 Metabolic reprogramming in HCC ACLY CIT HEL-S-133P HK2 FASN HEL-S-281 MAL CD36 HEL-S-162eP PMC3964053__F4 BMP signaling in germ cells across the Metazoa BMPR2 PRDM14 PGC SMAD4 GSC SMAD1 DKFZp781O1323 PMC4881575__F1 miRNA network regulating cancer metabolism MYC PTEN MTOR PMC3506510__F2 Signaling pathways impinging on autophagy TSC2 RICTOR TSC1 PTEN MTOR RHEB PMC6400995__F1 Kynurenine pathway with a focus on KYNA synthesis HAAO AHR ND3 KMO ND4 PMC3739348__F6 Expression of some genes related to the cell cycle and apoptosis were significantly changed after LM23 knockdown, as shown by microarray analysis CASP6 CDK2 APC MDM2 CDK4 CDC2 CDK6 PMC5549304__F6 H3K79 methylation pathway and potential therapeutic targets WAC RNF20 BRD4 PMC2694487__F5 Human presenilin 1 and 2 (PSEN1 and PSEN2) subnetworks SNCA PSEN2 LFNG PSENEN YKT6 GPR37 PMC5103945__F1 STRING analysis of metabolic and PI3K-Akt signalling pathways TUBA4A HEL-S-30 TUBB PLEC FLNA HEL-S-1 HEL-S-34 CLEC3B EZR KRT31 PSAP AMBP MDH2 HEL-S-22 CALM1 HLA-A HEL-S-49 YWHAQ ACSL1 PCBP1 HEL113 ACTN4 RPS12 FASN PMC4216117__F2 MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells IKBKB NFKBID SMAD2 MAPK14 IKBIP IL6 MTOR IRF2 CEBPB NFKBIE PMC4307283__F4 Lipids regulate apoptotic signaling in the cells CASP3 CASP6 CASP9 CASP14 CASP10 CASP8 CASP5 CASP4 PMC4519426__F5 Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes NUMB MAP2 ATF2 SMAD2 SMAD4 PTEN DLL3 FZD1 ADAM17 HDAC2 FURIN ETFA MAP3K1 MPDZ VEGFA CD44 DEK HBEGF HRAS RBX1 LNX2 RICTOR SMURF2 GRB2 HES7 TGFA PCNA SKP2 MIB2 FZD8 PMC5374431__F1A Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks PML HDAC3 CSNK2A1 MYC PTEN SUDS3 PACS1 TOP2A CHD3 UBC SAP18 NOLC1 APEX1 PTPN1 DVL2 HDAC2 SIN3A SSRP1 JUN APOE PAF1 SNCA RNF7 PAFAH1B1 FOS VAMP4 GAP43 HDAC1 DVL3 SEC63 DVL1 CALM1 UBTF NFKBIA EIF3F SPIB RELA GGA1 CSNK2B SIRT1 SUPT16H PMC5779957__F8 The top one Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of miR-146a-5p, hsa05200: Pathways in cancer TH LPA CRK PMC6691931__F3 CD40 signalling pathway MAPKAPK2 TANK TRAF3 ATF1 TRAF6 LTA FCER2 TRAF5 TRAF1 CD40 JAK3 TRAF2 STAT3 PMC7277573__F3 “Clathrin-coated vesicle cycle” pathway was enriched in both sexes VAMP2 PREB EEA1 BIN1 VAMP4 SNX9 RILP PICALM VAMP8 ARF1 VAMP7 YKT6 PMC5910217__F2 Interferon system CGAS STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 MAVS PMC8424549__F4 Regulation and metabolic functions of mTORC1 and mTORC2 OMP MYC RPIA IMPDH2 HEL-S-70p CAD HEL107 MTHFD2 PMC8424549__F7 Regulation and metabolic functions of mTORC1 and mTORC2 TFEB HTT PTEN MTOR RHEB PMC3948775__F2 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat HSD17B12 HSD11B2 STS HSD3B1 HSD17B1 CYP7B1 HSD17B7 SULT2B1 HSD17B3 HSD17B8 CYP17A1 CYP21A2 PMC7092451__F6 KEGG pathway analysis of targeted genes involved into proteoglycans in cancer pathway PIK3R5 HCLS1 SOS2 EZR DDX5 ACTG1 PMC3948775__F9 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat AGA TES PMC8230743__F13 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences PDE3B BAD HEL-S-30 INS GIP PFKL EIF4E MTOR CIT RHEB INSR HEL-S-5 TSC2 F2 PGC CRTC2 SIRT1 PYGL PMC6359475__F1 Extrinsic and intrinsic pathways of apoptosis FADD BAX PMC8230743__F12 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences ATG12 INS RHEB CFTR INSR TSC2 NLK RARA IGF1 ATM F2 CDK2 MDM2 BNIP3 POC1A SKP2 CD36 PMC7522985__F1 Biosynthesis and Metabolism of n-6 PUFAs and LC-PUFAs PTGIS LPCAT3 COX1 FACL4 MGLL TES ALOX15 PTGES LTC4S MBOAT7 HEL-S-5 ACSL5 COX2 FADS2 ADA FADS1 ACSL1 GLA PMC8102494__F1 Conserved apoptotic pathways TNF FADD BAX PMC9612159__F2 Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration NFATC1 OSCAR RGS12 RGS10 SIRPB1 PMC8869658__F1 Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris ADA APRT NT5E ADK PMC7956574__F3 Wnt/Beta-catenin signaling pathway in osteogenesis RUNX2 APC GSK3B SFRP1 PMC7956574__F2 BMPs and TGFB signaling pathways in osteogenesis RUNX2 SMAD2 SMURF2 SMURF1 PMC5555817__F2 Association analysis between chemical activity in the p53RE assay and chemical-induced increased expression of downstream genes in the p53 signaling pathway ATM MYC ATR PMC4034436__F1 Effects of the HIF pathway on mesenchymal stem cells (MSCs) RUNX2 CXCR4 MSC PMC3627370__F1 NAMPT in mammalian NAD metabolism NAMPT NRK PMC12175451__F1 Circadian clock entrainment pathways CRY1 CRY2 RORA NPAS2 PER2 PMC8720586__F3 Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis RARA LEP ATF4 RELA INS CEBPA INSR BAX PMC12175451__F2 Related signaling pathway CRY1 TLR4 MDM2 GADD45A PER1 STAT3 PMC9005294__F3 Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway PI3 BAD MMP2 MMP9 PDK2 MDM2 PTEN PMC12232070__F12 Mechanism of RME inhibiting the secretion of inflammatory factors by regulating the Dvl1/Wnt1/Beta-catenin/GSK-3B signaling pathway in the treatment of RA APC WNT1 LRP5 LRP6 DVL1 PMC2597184__F2 Nuclear Factor-kappa B Signaling in Skeletal Muscle Atrophy RELA RELB CD40 TNF LTBR PMC5181590__F3 Specific intracellular signalling pathways are predicted to be abnormally activated in resting HD monocytes CD14 TLR4 MYC STAT3 PMC3491070__F3A Cancer Cell Metabolism: One Hallmark, Many Faces MYC VHL PTEN PMC1951379__F6 IFN signaling during the clinical evolution of SARS STAT1 IFIT3 STAT2 TYK2 JAK1 IFITM1 CP PMC5376075__F3 TRL2 pathway is activated by Tollip and results in IRAK suppression IRAK1 RELA TRAF6 IRAK4 MYD88 TIRAP PMC8232321__F2 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology MAX TMEM100 EFNB2 BMPER VEGFA PMC8232321__F1 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC10531420__F6 Seasonal Developing Xylem Transcriptome Analysis of Pinus densiflora Unveils Novel Insights for Compression Wood Formation CAD PRX PMC4554190__F3 Illustration of data-enhanced Bayesian network inference MAP2K1 NRAS KLK3 MAPK1 SOS1 PMC4495315__F1 Signaling via the IGF-1R begins with binding of its ligands, IGF-1, IGF-2, or insulin, to the extracellular Alpha-subunit, and this in turn leads to phosphorylation of the intracellular Beta-subunits BAD IGF1R FOS IGF2 PTEN IGFBP5 IRS1 TSC2 IGF1 IGFBP1 IGFBP4 GRB2 IGFBP2 IGFBP6 JUN PMC3405133__F3 Identification of Pathway Deregulation – Gene Expression Based Analysis of Consistent Signal Transduction LEF1 FOS MYC CCND1 TCF7L2 TCF7L1 JUN PMC8630469__F1 Wnt/Beta-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways LEP APC GSK3B PMC3646329__F2 HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer TSC2 TSC1 BRAF EGFR PTEN PMC7892973__F2 Role of irisin-involved integrin signaling cascade in modulating tumor microenvironment remodeling TLR4 TRAF6 ARHA MYD88 MTOR FNDC5 CD81 STAT3 PMC8283807__F10 MitoROS-PKCG-mediated endoplasmic reticulum stress (ERS)-dependent induction of the TXNIP/NLRP3 signaling axis NLRP3 ATF4 TXNIP PMC7241820__F8 Long noncoding RNA PAHAL modulates locust behavioural plasticity through the feedback regulation of dopamine biosynthesis HAL PAH PMC7373860__F5 Frequently altered cancer pathways for TP53 using gene set enrichment analysis pathway enrichment in hepatocellular carcinoma BAD E2F4 RASGRF2 FLNA CDKN1B RB1 CSF2RB CDKN2A BCL2L14 MAP2K6 CDK6 CCNE1 CDKN2B CDK2 E2F2 CCND1 CDK4 HSPA1A ATR RBL2 BAX PMC11806886__F5 Combination strategy to suppress tumor cell proliferation in anti-HER2 resistant PTEN-deficient breast cancer cells PTEN MTOR FASN CD36 PMC7840025__F1 Association of a novel endometrial cancer biomarker panel with prognostic risk, platinum insensitivity, and targetable therapeutic options PIK3R1 PIK3IP1 CCNA2 PLK1 FOXM1 BRIP1 GSK3B PTEN HCTP4 MRE11A BRCA1 AURKA CCNE1 CIP2A BRCA2 RAD50 PIK3CA RAD51 EZH2 MASTL ESPL1 SKP2 PMC2794539__F5 Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells SORT1 SNCA PLAUR MAPK10 VCAN CPNE1 TMC6 CTSH HRNR NRP2 NGFR DCT UNK JUN TCF4 APOE PMC5138060__F1 TNF axis in cancer progression and metastasis TRADD TNF TRAF2 FADD PMC6863034__F4 (A–C) The most significance predictive genes for renal ischemia-reperfusion injury (IRI) in the rat model CD14 CXCL1 ADAM8 CLEC4D FLNA MYC CD44 CCL2 MMP3 ITGAM RAP2B IGF1 ITGA6 THBS1 STAT3 PMC10297376__F2 PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds ULK1 BAD PTEN RHO EIF4E MTOR DEPTOR RHEB MLST8 TSC2 RICTOR TSC1 SESN3 CCND1 PMC6927050__F8 Schematic diagram of hypoxia-induced pyroptosis in myoblasts NLRP3 PAX7 GSDMD PMC1832150__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1-8 COQ3 COQ2 COQ6 COQ5 COQ7 PMC8589438__F1 Anti-cancer drugs often work by the induction of apoptosis BAD BMF BAX PMC3237753__F7 GAq - Ca2+ signaling pathway promotes actin-mediated epidermal wound closure RHO CDC42 PMC11984396__F3 Diagram of cellular immunity mediated by splenic immunocytes TH APC HEL-S-92n PMC5891205__F9 Radioresistance is associated with G2/M arrest and repression of apoptosis pathway by upregulation of Bcl‐XL, Bcl‐2 and CyclinB1/CDK1 and downregulation of p53, p21, Bax, Caspase‐3 and cleaved PARP in colorectal cancer (CRC) CCNB1 RBBP6 BAX PMC4451058__F2 Prostaglandin pathways in duodenal chemosensing PGP DUOX2 NOD2 CFTR PMC8688651__F1 Network map of apelin-mediated signaling SPG20 ACACA RELA SPOP POR MAL PMC5656035__F3 Proximal components of the TNF signaling pathway TRADD TRAF1 TRAF2 FADD PMC7434656__F2 Interactions of TGFB and RAAS signaling SMAD2 SMAD4 CTGF PMC4448615__F1 Plant and yeast cell walls (CWs) TSC2 TSC1 PMC8628488__F2 Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides PDK2 GSK3B INSR PMC5966782__F1 Glucose catabolism PSPH PHGDH PMC5536941__F3 APC-dependent role of CtBP in the Wnt/ Beta-catenin pathway APC LRP5 CCND1 LRP6 PMC11984396__F8 Activation of CAP by electrical cervical nerve stimulation and splenic ultrasound stimulation to combat inflammation TH ChAT PMC6592229__F2 Inhibition of DNA end resection promotes cNHEJ.DYNLL1, shieldin and UBQLN4 inhibit DNA end resection thereby promoting DSB repair by cNHEJ DNCL1 RIF1 BRCA2 RAD51 MRE11A BRCA1 PMC11984396__F6 Molecular mechanisms underlying neuro-immune interactions FPR1 TRPA1 VIP TRPV1 STAT3 TRPM8 PMC6592229__F1 Balancing DNA double-strand break (DSB) repair.Homologous recombination repair (HR) and classical non-homologous end joining (cNHEJ) are orchestrated in a balanced DSB repair response BRCA2 RAD51 BRCA1 PMC4764462__F2 Transcriptional control of cardiac fibroblast plasticity KLF15 TRPC1 SMAD2 KLF5 TRPC6 ARHA TRPC3 PMC3484588__F4 Cellular affects of TNFA.Tumour Necrosis Factor alpha (TNFA) is produced by macrophages, lymphocytes, fibroblasts and keratinocyte TRADD CD40 TNF TRAF2 FADD PMC11670415__F1 Necroptosis activation in AD RIPK1 RIPK3 TNF MLKL PMC3482685__F2 Regulatory function of TIR8/SIGIRR in signaling TLR5 TLR7 TLR4 TLR9 SIGIRR CCND1 MYD88 MTOR TLR3 PMC9237949__F7 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell LYN GRB2 SYK PMC12027629__F1 Keratinocyte-derived EVs modulate immune cells and promote inflammation in psoriasis CXCL1 CXCL5 TGFBR1 CXCL8 CXCL6 CXCL3 IFNG PMC6895929__F2 Molecular networks enriched by miRNAs differentially expressed in H1299/mutant p53R273H cells BAMBI SGCA MAD2L1 VCAN MIOS LAMB3 NTRK3 TRPS1 RPS15 EPHB6 SLC38A1 MAFA ARHG GALNT7 SUFU ACP2 NAPG C10orf104 PMC9237949__F1 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell HLA-G HEL-S-11 LYN GRB2 SYK KIR2DL4 PMC4976833__F1 Cell density regulates cancer metastasis via the Hippo pathway MOB2 AMOT LATS2 PMC5095034__F7 Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification IGF1 CXCR4 STAT3 PMC11560455__F1 Ferroptosis signaling pathway GPX4 LPCAT3 STEAP3 FACL4 TFRC SLC40A1 DHODH TF PMC8913698__F8 Co-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars DAO PMC7403513__F11 The impact of CFTR dysfunction in HLMVEC on oxidative stress, inflammation and angiogenesis EGFR CFTR PMC8991687__F1 Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma RUNX2 DKK1 CCL3 PMC9285118__F1 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer NLRP3 IL1B GSDMD PMC5567913__F9 Graphical summary of the results SMAD2 SMAD4 NOX4 TBR1 PMC9285118__F2 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer GSDMA GZMA DFNB59 GSDMB GSDMD DFNA5 PMC3133824__F2 Mechanisms for import and export of proteins to and from the nucleus NTS RAN PMC3133824__F1 Cytonuclear signaling pathways in MSNs HEL70 PMC7716119__F4 Differentially expressed mRNA of the ceRNA network was significantly enriched, to create a meaningful MAPK and FoxO signaling pathway map CD14 EGF DAO INS SMAD4 PTEN IL6 MIP INSR NLK BTK IGF1 MAX ATM CDK2 MDM2 CYC1 ECSIT KLF2 BNIP3 SKP2 STAT3 PMC4344212__F4 Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing PDX1 BACE1 NR5A2 BACE2 GCK MNX1 ONECUT1 HSD17B10 NKX6-1 NR2A2 HES1 NAE1 IL18 SLC2A2 PKLR APP FOXA3 NEUROD1 PSEN2 TNF TCF2 PAX4 IAPP HEL-S-162eP MAFA FOXA2 CASP3 NKX2-2 NEUROG3 HNF4A PSENEN MME HHEX PMC8570012__F1 Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance CCL8 CXCR1 EGF CXCL1 CXCL10 MSC CCL5 HIC1 STAT3 PMC9446437__F3 Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development MUC1 HGF EFNA1 THBS3 EGFR GRB2 SRC PTEN MTOR PMC8226806__F2 Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension BMPR2 CXCR4 MSC KLF4 SHH CXCL12 FGFR2 PMC11938631__F6 Mechanisms of Shh signaling pathway in maintaining BBB integrity PTCH1 SHH SMO PMC9601273__F4 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer NR1i1 CXCR4 GSK3B LRP5 CCND1 LRP6 PMC11612781__F3 From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling CRY1 EGR1 EGR2 GRB2 AVP VIP PROK2 PER1 PMC11938631__F8 Major common pathways regulating BBB integrity after TBI and in AD PTCH1 MMP9 SHH SMO MTOR PMC11938631__F3 Multifaceted roles of TGFB signaling in BBB integrity SMAD2 TGFBR1 TGFBR2 SMAD4 PMC9666724__F4 Functional and clinical characteristics of focal adhesion kinases in cancer progression VEGFC CXCL10 SRC CCL7 CCL5 PMC11938631__F5 Activation of the Wnt/Beta-catenin signaling pathway maintains the BBB integrity APC PMC9666724__F6 Functional and clinical characteristics of focal adhesion kinases in cancer progression EGFR HDAC2 ARHA LATS1 LATS2 HDAC1 PMC9601273__F3 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer EGF SOCS3 EGFR VEGFA STAT3 PMC4183521__F5 Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control AVP TRPC6 TPR PMC7998619__F2 Viral immune evasion in the placenta utilized by cytomegalovirus (CMV) and Zika virus TLR9 IRF7 IRF9 CXCL8 IRF3 IL6 CCL2 MYD88 TNF TLR3 TLR7 CD80 MAVS PMC9601273__F2 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer CXCL1 SAFB VEGFA GNA13 CXCL2 MTDH PMC9601273__F1 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer CCR7 VEGFA SRC CCL19 SRCIN1 PMC8861501__F7 Integrative Analysis of the lncRNA-Associated ceRNA Regulatory Network Response to Hypoxia in Alveolar Type II Epithelial Cells of Tibetan Pigs H1-0 ENO1 PFKL HEL-S-87p IFNG PMC2683871__F6 p53-regulated pathway analysis using the Ingenuity Pathway Knowledge Base (IPKB) TANK THBD JMY CCNH TSG101 TP53INP1 MMP3 PERP ZNF148 PC4 S100A4 KLF6 CCNE2 PLK2 CD82 CSTF1 NR3C1 PHLDA1 DDIT4 NFKB1 CYFIP2 SESN1 HMGN2 PEG3 AK1 PMC4021575__F3 Ribosome assembly and Insulin signalling pathway TSC2 BAD LTA SI HEL-S-11 INS RHEB INSR PMC1769521__F2 Senescence via tumor suppressor pathways PML CDK2 TBX2 MDM2 CDK4 BMI1 CDK6 PMC6943030__F2 Section from a pathway that describes the biosynthesis of Lewis-type epitopes by the bacterium Helicobacter pylori HP GALP PMC8625890__F8A Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review CASP3 BAD ERG POLK APC MSH6 GRB2 SMAD4 BAX PMC4948992__F3A Regulation of biomechanical signals by NFKB transcription factors in chondrocytes COX2 NOS2 IL1B PMC2780914__F3 Transmigration causes differential expression of genes in the apoptosis pathway NAIP ROCK1 CAD TNF GAS2 PMC7446622__F1 Inflammation during SARS-CoV-2 infection.SARS-CoV-2 invade host cells with angiotensin-converting enzyme2 (ACE2) receptors present on the cell surface membrane NLRP3 TLR4 MYD88 PMC7446622__F4 Putative role of Gsk-3 in the SARS-CoV-2 replication and COVID-19 pathogenesis.Activated Gsk-3 phosphorylate the nucleocapsid protein of SARS-CoV-2 and support viral genome replication and transcription KEAP1 TRAF6 MYD88 TIRAP PMC7446622__F3 Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic TLR4 VWF TF PMC8838156__F1 Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia CD14 TLR4 TRAF6 IRF3 MYD88 PMC9099292__F7 Transcriptome Analysis Reveals the Molecular Response to Salinity Challenge in Larvae of the Giant Freshwater Prawn Macrobrachium rosenbergii HMGB2 PMC3355540__F2 Nuclear receptors and photoreceptor differentiation in mice SALL3 CRX NR2E3 RORB RXRG OTX2 RORA NR2E1 PMC7476096__F4 Effect of miR-135a on the epithelial-mesenchymal transition (EMT) CDH2 KLF8 PMC6697794__F8 Schematic diagram represents that leptin signaling-dependent activation of mTORC2/Phllp1/Akt pathway abrogates lysosomal function and negatively regulates macrophage defense during S LEPR PHLPP1 STAT3 PMC7476096__F3 Effects of miR-135a on cancer progression and relevant targets and signaling pathways ROCK2 PHLPP2 ROCK1 EGFR APC BMI1 RBAK FOXO1 SIAH1 VLDLR IGF1 MTSS1 CCND1 HOXA10 STAT3 KLF8 PMC2855089__F2 NFKB Signaling Pathway TLR4 TRADD TRAF6 MYD88 TNF PMC2643306__F1 Structure-function relationships in methionine adenosyltransferases HEL-S-61p PMC6984792__F8 Mechanism of action of ASB in UV-induced photo-damage in HaCaT cells KEAP1 GCLC IL1B PMC8468723__F3 NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective GSK3B PCNA STAT3 PMC4515750__F1 Diversity and complexity of dicer dependent small RNA networks in animals AGO2 DICER1 TES DROSHA PMC4767488__F1 Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis DKK3 APC GSK3B SFRP1 PMC9654300__F2 Aberrant B Cell Signaling in Autoimmune Diseases CSK MYC TRAF6 PTEN MTOR BLK CD79B CD79A PTPN22 BTK CARD11 CD72 BCL10 BCR BANK1 CD22 LYN SYK CD19 PMC3655383__F2 Importance of white adipose tissue (WAT)–skeletal muscle crosstalk in cancer associated cachexia (CAC) and/or lipotoxicity G0S2 EIF2A IL6 TNF IL6R IRS1 CD36 PMC8918699__F1 Large granular lymphocytic leukemia: a brief review MCL1 SP1 FADD STAT3 PMC5374157__F1 Type I interferons (IFNs) and different other cytokines are essential for natural killer (NK) cell homeostasis and function IL15 IL18 TRAF6 IL2 TYK2 JAK3 IFNAR2 MYD88 IL-21 JAK1 IFNAR1 PMC7872201__F1 Targets of acetylation/deacetylation in metabolic pathways known to affect I/R injury FH ACO2 SDHA MDH2 HEL-S-5 SIRT3 PMC8766720__F6 MiR-27a-3p Targets GLP1R to Regulate Differentiation, Autophagy, and Release of Inflammatory Factors in Pre-Osteoblasts via the AMPK Signaling Pathway RUNX2 DKFZp686F0183 GLP1R PMC5610088__F1 Phospholipid biosynthetic pathways in Streptomyces PGP LPA PSD HEL-S-5 PMC5763468__F2 MCF7-related generic pathway map BAD PLK1 ATM RRM2 EGFR BCL2 MTOR HDAC1 BRCA1 INSR PMC5291233__F6 Impact of pridopidine treatment on BDNF signalling, AKT activation, and the glucocorticoid pathway EGR1 FOS HOMER1 PDK4 DDIT4 CEBPB NFKBIA CDKN1A EGR2 MDM2 ARC BDNF NTRK2 GPD1 PMC5043072__F3 Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection SYNE2 NR5A2 BRAF RTKN DES CELSR3 MTOR UBB DTL SP100 FOXD3 COL4A6 HTT DVL2 NCOA1 PECAM1 RBL2 TUBB PLEC APC PRLHR SPTB PRKACG MAPKAP1 HEL-S-125m TSC2 SIRPA INSIG1 DMAP1 RYR1 SMG1 ARHGAP21 HEL-S-93 TMOD3 AGAP2 PMC5763468__F4 MCF7-specific signaling pathway network inferred by TILP model BAD PLK1 ATM RRM2 EGFR BCL2 MTOR HDAC1 BRCA1 INSR PMC4060203__F1 Schematic showing the details of the estrogen pathway HSD3B1 HSD17B1 CYP17A1 PMC4849044__F2 Schematic diagram illustrates the role of matrilin-3 in ECM modulation of cartilage MMP3 COX2 ADAMTS4 ADAMTS5 BMP2 MATN3 SMAD1 IL1B PMC3094097__F3 Examples of cellular receptors that sense infection and cell death HMGB1 TLR4 TLR9 IRF3 PMC2393790__F3 Citrate cycle genes are up-regulated in the brains of nurse bees CS PC FH DLD OGDH ACLY SDHA PMC155330__F7 slpr, encoding Drosophila MLK, is the MKKK for the Jun kinase pathway during dorsal closure in the fly HEL70 ATF2 GCK CDC42 PMC9091111__F5 Curcumin treats endometriosis in mice by the HIF signaling pathway CASP3 EGF FOS NFKB1 GSK3B VEGFA PPARG JUN PMC9091111__F4 Curcumin treats endometriosis in mice by the HIF signaling pathway GSK3B ALOX5 BCL2L1 HIF1A PTGS1 HMOX1 TRPV1 CCNE1 MMP2 CASP9 NOTCH1 HDAC2 NOS2 FOS VEGFA FOXO1 AURKB CDKN1A PCNA EGF LIPC EGFR ALOX15 MTOR TOP2A CYP1A2 RARB TLR4 SHBG CCND1 CYP1A1 ABCG2 IL1B JUN MMP9 PTGS2 NFE2L2 PTGES IL6 NR1C1 AURKA CASP3 RPS6KB1 ERBB2 NFKB1 MCL1 TNFRSF10B PPARG STAT3 PMC3657702__F1 Age-related alteration of gene expression in the TCR signaling pathway ITK FYN BCL10 LCK GRB2 CD48 CTLA4 LAT ICOS CBL PMC11580395__F2 Interaction between the sonic hedgehog signalling pathway and other molecular pathways TSC2 TSC1 SUFU APC GLI3 GSK3B SHH SFRP1 SMO MTOR RHEB PMC11580395__F1 SHH pathways in tumorigenesis and their types (canonical and non-canonical) BOC CDON SUFU GLI3 CCNB1 SHH SMO PMC5438149__F7 Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro GCM1 RHO RAC1 PMC3565545__F10 CHEK kinase pathway showing the role of CHEK proteins in cell cycle checkpoint control, and crosstalk with other pathways notably the P53 and BRCA pathways.Notes: Double circles indicate complex interactions involving multiple genes RAD1 ATM CDK2 HUS1 RAD50 ATR BRCA1 PCNA PMC11857725__F2 The metabolic pathway of tryptophan and phenylalanine in ADHD TH ASMT KYNU PNMT DDC DBH PAH AANAT PMC9249328__F8 Identification of VdASP F2‐interacting protein as a regulator of microsclerotial formation in Verticillium dahliae F2 RAC1 VTA1 PMC11364484__F2 TGFB and BMP receptors and their signaling pathways BMPR2 ACVRL1 GIG8 ACVR2A BMPR1A SMAD2 SMAD4 ID1 SMAD1 DKFZp781O1323 PMC7808269__F5 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy PLSCR1 CD9 MARCKS PIM2 CMPK2 MYC CCL7 CCL2 MAF ARL4C STAT1 HEL57 OAS3 KDR NOS2 IRF-1 APOE HIVEP2 IRF7 STAT2 IRF9 LCN2 HEL110 PROCR IL12B IL15 VCAM1 IGFBP4 DUSP16 GPR183 CCR3 IL12A MX2 CCND2 MX1 GADD45B IL18 KYNU KMO THBS1 IRF4 CHI3L1 PSMB8 IL10 CFB IFNB1 TLR1 SLFN13 HLA-DOA SLFN12L HP TNFSF10 IL27 STAT4 CD40 IL20 GBP4 ANGPTL2 IFITM2 MYD88 USP18 BATF PRTN3 OASL CH25H TREML2 MCM10 CSF2 PSMB9 RSAD2 VCAN AK4 GADD45A RXRA ADAR ZFP36L2 ISG20 DUSP8 CP PML IFIT2 IKBKE DHX58 HGF IFNA4 CSF3 TRIM21 ITGA4 CSF2RB NOCT HDC GBP2 IL2 ELANE JUN IL1B PF4 MMP9 GJA1 CTSC REL ETV5 IL18RAP GPR84 INHBA PMC7808269__F4 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy CLEC12A DPP4 CSF3R CXCL3 CCL5 CCL2 CCL3L3 HEL-S-104 CEBPB CORO1A ISG15 SLAMF8 MARCO STAP1 CCND1 CXCL6 NMI ARG1 S100A4 c-fgr FPR1 MMP9 CXCL10 FPR2 CYP11A1 CCL4 IL6 S100A9 TNLG2B TNF DDIT3 GPR18 TUBA1A VLDLR LTA TREM1 CD72 NFKB2 VCAM1 FBXO32 CXCR4 S100A8 TREX1 CD40 CCL22 MEFV SIGLEC9 RASGRP4 PMC10506516__F6 Schematics of proposed pathway for beneficial effects of L-carnitine on lipid parameters CPT2 NR1C1 HMGCR PMC2597730__F7 Cascade between VEGFA, a direct target of BP1, and its downstream target genes in cell proliferation PLAT SMARCA4 BRAF CRH ERBB3 GRPR SELP CGA ID1 BPI PER2 PDPK1 PMC9234279__F6 Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NFKB Signaling Pathway in vitro and in vivo MMP2 MMP9 PMC7848207__F2 Mechanisms of action and signaling pathways of SIRT1 in diabetic nephropathy KEAP1 CLDN1 NOX4 EZH2 SIRT1 FOXO1 HIC1 PMC11667996__F3 EBV-Driven Oncogenesis: Manipulating MAPK Signaling and Apoptotic Pathways: EBV promotes tumorigenesis through the MAPK signaling pathway, manipulating host cellular mechanisms CD47 TNLG8A SP1 DUSP8 EPHA4 PMC11830326__F6 Signaling pathways involved in repurposing drugs in cancer therapy MDM2 DAP MTOR STAT3 PMC11667996__F2 Oncogenic Role of H GRB2 SRC ARHA PMC11667996__F1 Activation and signaling pathways of the MAPK Cascade: an overview of stimuli, cascades, and downstream targets: this detailed illustration outlines the four central signaling pathways within the MAPK framework: ERK5, ERK, JNK, and p38/MAPK TSC2 TSC1 IRAK1 GRB2 TRAF6 IRAK4 SP1 PMC8651430__F2 Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It ACE2 PMC6170679__F7 Model summarizing the proposed signaling events in the myeloid CXCR4 deletion mice CXCR4 IFNG PMC11830326__F3 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers LEF1 JAG2 GATA3 PMC11830326__F2 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers SMAD2 ZEB2 SMAD4 PMC11830326__F5 Dietary phytochemicals targeting Wnt, TGFB, JAK/STAT, NOTCH, PI3K, and TNFA signaling pathways involved in EMT transitions SMAD2 TNF MTOR GATA3 PMC9270757__F3 Regulatory function of DNA methylation mediated lncRNAs in gastric cancer SNCG HOXA13 RUNX3 ACOT7 EGFR PTEN CDH2 SP1 DNMT3B MED18 PCDH10 PMC11830326__F4 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers TFG HEL-S-28 SMAD2 ZEB2 GSK3B SNAI2 SMAD4 ARHA PMC6827018__F8 Schematic representation of the entire signaling pathway FOXC1 LATS2 TF PMC8589460__F1 Therapeutic strategies targeting Wnt/Beta-catenin signaling for colorectal cancer (Review) APC GSK3B MYC LRP5 LRP6 PMC3807052__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue CXCL8 IL1B PMC3111743__F6 Correlation network among processes with activity modified by both OEA and KDS-5104 treatments is shown CD36 PMC7938465__F5 Re-analysis of 15 selected genes via KEGG pathway enrichment analysis CASP3 TSC2 AIFM2 PERP ATM MYC CASP9 PTEN ATR SIVA1 BAX PMC8306455__F5 Evasion of the Host Immune Response by Betaherpesviruses TBK1 EGF CGAS EGFR TRAF3 TRAF6 IRF3 MYD88 MTOR TLR3 TLR4 BCL2 FADD BAX PMC8306455__F4 Evasion of the Host Immune Response by Betaherpesviruses EGF EGFR BCL2 PTEN MTOR FADD BAX PMC7938465__F3 Protein-protein interaction (PPI) network of DEGs HHIP CDKN3 CRHBP SULT1E1 LPA DTL DCN C9 APOF GHR HGFAC BCHE CXCL14 ALDOB CYP2B6 HAMP GLS2 CTHRC1 GYS2 HMMR IGF1 CYP2C9 CNTN3 CLEC1B ADRA1A CXCL12 HGF CNDP1 IDO2 NAT2 TOP2A CYP1A2 IGFALS SLC22A1 FCN2 CAP2 CYP26A1 PRC1 ECT2 KMO RRM2 SRPX SPINK1 opn GPM6A CCNB1 SRD5A2 CDC2 VNN1 GPC3 FCN3 HAO2 CXCL2 CYP2A7 CYP2A6 MT1M ACSM3 HEL-S-4 TTC36 BUB1B NEK2 HEL164 AKR1D1 ROBO1 PMC8306455__F3 Evasion of the Host Immune Response by Betaherpesviruses TBK1 TRAF3 TRAF6 IRF3 MYD88 PMC8306455__F2 Evasion of the Host Immune Response by Betaherpesviruses TBK1 CGAS IRF3 PMC6018831__F3 Metabolic reconstruction of LSUCC0530 CTH BAD CIT MAL PMC7213295__F1 PI3K/AKT/mTOR/NFKB Pathway in Ovarian Cancer TSC2 TSC1 PTEN INPP4B MTOR DEPTOR RHEB MLST8 PMC156240__F1 Xu-5-P is the signal for the coordinated control of lipogenesis CIT HEL-S-5 HEL-S-162eP PMC11172960__F4 Molecular targets of natural product-derived compounds for psoriasis treatment CEBPD STAT1 NLRP3 RELA CCL20 SIRT1 SKP2 STAT3 PMC11172960__F2 Putative molecular targets and their associated signaling pathways for psoriasis in keratinocytes NLRP3 HMGB1 AHR FRK FABP5 VCP AIM2 SIRT1 STAT3 PMC6801309__F1 An overview of myocardial energy substrate utilization CPT2 CD36 HEL-S-5 PMC11172960__F1 Signaling pathways in psoriasis pathogenesis in keratinocytes TRADD PTGS2 CXCL10 IL6 IL17RC S100A7 STAT1 VCAM1 S100A8 CCL20 CXCL9 TYK2 JAK1 TRAF2 CXCL11 STAT3 PMC8027889__F1 AHR and its signaling pathway IDO1 AIP AHRR AHR CYP1B1 SRC CYP1A2 PMC2913337__F2 Cross talk of the Nodal/Cripto-1 signaling pathway with Wnt, hypoxia, Notch, Oct-4, and Nanog signaling pathways NODAL SMAD2 NOTCH1 FZD7 GDF1 GDF3 PMC4111689__F1 Targeting the Achilles’ heel of drug-resistant cancer stem cells EGFR RALB PMC6401303__F6 It’s complicated… m6A-Dependent Regulation of Gene Expression in Cancer YTHDF2 SOCS2 METTL3 PTEN PMC3570385__F1 Signal transduction pathway through TLR TLR7 TLR4 TLR9 TRADD TRAF6 TNF MAP3K7IP1 FADD TLR3 PMC9027306__F2 MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies GSK3B GRB2 SIX1 CA9 HEL-S-133P HK2 PMC7563658__F1 Canonical and non-canonical nuclear factor K (kappa)-light-chain-enhancer of activated B cells (NFKB) signalling pathways RELA RELB CD40 PMC3759646__F1 Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia IGF1R IGF1 ALK MTOR IRS1 PMC2948541__F5 Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders ATF3 TXNIP BTG2 NPAS4 SERPINB2 INHBB FOXO1 BCL6 BAX PMC6731550__F4 Intracellular pathways targeted by disease pathogenesis in FTLD UBQLN2 SQSTM1 WDR41 SMCR8 C9orf72 VCP OPTN PMC7666787__F7 Role of Tim-3 in breast cancer VEGFA CCND1 VEGFB STAT3 PMC7878551__F6 Hypothetical model for Gram-negative bacteria induced major innate immune response in horseshoe crabs A2M LBP MYD88 PMC9368391__F1 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections TBK1 NLRP3 TLR8 TLR7 DDX3X RIPK3 MYD88 TLR3 ZBP1 MAVS MLKL IFI16 PMC7343516__F8 Schematic diagrams showing the potential mechanism in the protective effects of Epothilone B on LPS induced inflammatory bone destruction CTSK NFATC1 MMP9 STAT3 PMC9368391__F3 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections TBK1 NLRP3 TLR8 RIPK1 TLR7 NOD1 RIPK3 MYD88 IL1B TLR3 MAVS PMC6138031__F2 Illustrative model of the IFN signal transduction pathway STAT1 TYK2 IFNG PMC2391069__F1 Overindulgence and metabolic syndrome: is FoxO1 a missing link? DGAT1 APOB DGAT2 PDK2 TG FOXO1 PMC5192062__F2 IL-17 and IL-17 receptor family EBP TRAF6 IL25 IL17RB IL17RC PMC2583496__F2 Global regulation of the E HP RELA CRP RPIA PMC7657662__F2 Schematic depicting the complex I assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics COA1 NDUFV3 ZNF183 NDUFAF1 NDUFS1 NDUFB8 NDUFA12 NDUFA9 NDUFA11 NUBPL TMEM70 NDUFS8 NDUFAF6 NDUFAF4 NDUFS4 NDUFAF2 NDUFB9 NDUFA6 FES NDUFC2 NDUFB7 NDUFB3 ND5 ND4 NDUFAF5 TIMMDC1 ND4L NDUFA5 NDUFA13 NDUFB10 ECSIT NDUFS5 NDUFB6 NDUFB5 NDUFB11 NDUFS6 NDUFV2 NDUFA7 NDUFB2 NDUFAB1 ACAD9 NDUFS3 C3orf60 TMEM186 TMEM126B ND6 DMAC1 NDUFA2 NDUFB4 NDUFAF8 ND3 NDUFB1 ND1 ND2 NDUFA3 NDUFC1 NDUFA10 PMC3321461__F1 Proposed mechanism for overcoming HNSCC resistance to EGFR antagonists using PI3kinase/Akt/mTOR and NFKB-IL6-STAT3 pathway inhibitors EGFR IL6 STAT3 PMC2694580__F2 Biological actions of isoprenoids BMP2 ARHA RAC1 CDC42 PMC6605362__F1 Schematic showing methionine metabolism reactions HEL-S-61p MTR PMC7657662__F4 Schematic depicting the complex III assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics UQCRB FES UQCRC2 UQCRFS1 UQCR11 UQCC3 UQCC2 UQCRH UQCRC1 UQCC CYC1 UQCR10 TTC19 LYRM7 UQCRQ PMC7657662__F3 Schematic depicting the complex II assembly pathway showing known mitochondrial disease genes in red and assembly factors in italics SDHAF1 SDHC SDHAF3 FES SDHAF4 SDHAF2 SDHD SDHA SDHB PMC7657662__F6 Schematic depicting the complex V (F1F0-ATPase) assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics ATP5G1 ATP6 APAF1 F2 ATF2 ATF1 ATP5J ATP8 PMC7657662__F5 Schematic depicting the complex IV assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics COX14 COX1 SCO2 COA1 COX5A COA3 COX2 COA6 CMC1 COX18 FAM36A TACO1 COX10 COX19 COX11 SURF1 PET100 COX7B COX7C COX8A HIGD1A COXFA4 HIGD2A COX3 COX16 COX17 PET117 TMEM177 PMC4845178__F1 Dormancy programs and their potential use in patient treatment RARA RARB SOX2 BMP7 NR2F1 SOX9 PMC4637164__F1 Activation of the complement cascade and its role in tumorigenesis HEL-S-62p C9 MASP1 C7 C6 MASP2 C4A PMC4198062__F8 Possible mechanisms by which phosphorylation of PAGE4 at T51 could potentiate the transactivation of c-Jun but weaken its affinity for c-Jun HIPK1 PAGE4 TXN PMC9667740__F1 Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment HTRA1 CD59 MASP1 FH THSD7A PMC5527958__F1 RTK activation BRAF LBR PTEN MTOR PMC4026364__F1 Tumor Suppressor p53 and Estrogen Receptors in Nuclear–Mitochondrial Communication TIGAR SCO2 MDM2 TFAM PMC3635737__F8 CCDC22 deficiency in humans blunts activation of proinflammatory NFKB signaling COMMD8 COMMD1 CCDC22 PMC5173152__F6 Wnt/Beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling LEF1 EP300 PMC7462931__F7 Hypothesis how decreased expression of glucose transporters in brain leading to a decreased intracellular d-glucose concentration in neurons may promote the emergence of AD OGA OGT APP PMC7100557__F2 MERS-CoV inhibits innate antiviral signaling TLR8 TLR7 STAT2 IRF9 RIGI IRF3 TLR3 MAVS PMC7947863__F2 LncRNAs regulate CRC metastasis through protein binding FBXO45 SIAH1 HNRNPA2B1 MTOR PMC11492922__F3 Enriched KEGG terms and PPI network highlight upregulated genes involved in immune response and inflammation MYB BAD TNFRSF12A PTEN CD300A IL6R COX2 LCP2 BCR MDM2 GNG11 GAL CCL27 LAMC2 RBL2 CD19 SNX10 SERPINE2 IRS1 BRCA1 RHEB CD69 TSC2 KLRB1 CYC1 CDC42 COL4A1 PMC3137772__F2 De novo biosynthesis of dolichol phosphate in human DHDDS SRD5A3 IPP PMC2735334__F1 Carcinogenesis of Bcr-Abl in CML BAD BCR BCL2 PMC8172611__F9 Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells PLK1 CDC2 MTOR DKFZp686F0183 PMC6478123__F2 Regulation of fatty acid oxidation, mevalonate pathway, and arachidonic acid metabolism by p53 LPIN1 ALOX5 ACLY HEL-S-20 PANK1 PMC2945811__F1 FA-regulated ICL repair FAN1 FAAP24 ATRIP FANCM ATR PMC12183059__F1 Molecular mechanisms of ferroptosis GPX4 LPCAT3 STEAP3 FACL4 KEAP1 SLC7A11 GCLC ALOX15 VDAC3 IPP HMOX1 ADA HEL-75 SLC3A2 PMC3924162__F2 Signaling pathways in PCSCs NOTCH2 EGF SOX2 PTCH1 GLI3 SHH NOTCH1 SMO BMI1 PMC3698976__F2 Methionine metabolism: transmethylation pathway HEL-S-61p PMC5064220__F7 Signaling network connecting RAS and mir-200 regulates apoptosis and EMT in cancer cells ZEB2 BCL2 SP1 JUN PMC5075711__F1 Formal modeling and analysis of ERA associated Biological Regulatory Network in breast cancer IGF1R EGFR MDM2 IRS1 BRCA1 PMC9039220__F3 Challenges and Opportunities Associated With Platelets in Pancreatic Cancer MMP9 NOTCH1 CCND1 BCL2 ARHA CDH2 PMC3743449__F5 Illustration of the hypoxia-inducible factor (HIF) activation pathway, highlighting hydroxylation and acetylation of HIF-1A depending on cellular oxygen tension, that is, normoxia and hypoxia EGF HGF IGF1 IGF2 VHL MTOR TGFA IL1B TF PMC3743449__F4 Classical example of NFKB is the heterodimer of p50 and p65 and the classical activation pathway entails the release from its association with an inhibitory molecule of the IKB family VCAM1 TRAF1 VCP IL1B TF IFNG PMC7459646__F7 Effect of parental Se nutrition on the methionine cycle and transsulfuration pathway in the progeny of rainbow trout HEL-S-61p HEL-S-182mP MTR PMC4508672__F2 HSV-I and the cellular DNA damage response RNF168 RNF8 FANCD2 ATM ATRIP ATR PMC6256264__F7 Schematic summary of molecular mechanisms for duhuo jisheng decoction (DHJSD) on the lower back pain (LBP) caused by Bi Zheng CXCR4 RHO JUN PMC22464__F5 Metabolic reaction network analyzed from the human erythrocyte containing 29 metabolites and the related 51 fluxes (37 internal and 14 exchange fluxes) TK1 HEL-S-162eP PMC2784255__F1 Examination of Tetrahydrobiopterin Pathway Genes in Autism SPR TH PTS GCHFR CIT PAH PCBD1 PMC3785791__F1 Abbreviated pathway to illustrate cGMP production and its role in oocyte meiotic arrest NPR2 PDE3A NPPC PMC7212408__F3 Notch signaling activity and Hippo pathway in BCSCs LATS1 MOB1A MOBKL1A LATS2 PMC7212408__F2 Activation of MAPK signaling pathway in BCSCs EGF FOXO3A DUSP9 EGFR SNAI2 DUSP16 SUZ12 GATA3 PMC555938__F6 The metabolic shift pathway of yeast Saccharomyces cerevisiae according to the dynamic regulatory modeling in Table 2 HEL-S-49 FBP1 DEHAL1 ENO2 HSF1 PMC555938__F5 Pathway of circadian regulatory system of Arabidopsis thaliana according to the dynamic regulatory modeling in Table 1 CRY1 ELF3 CRY2 PMC8113651__F2 Effect of autophagy modulation on HIV-1 infection ULK1 LAPTM5 ATG16L2 ATG12 CLN3 ARF6 PIP5K1A DKFZp686F0183 PIK3R4 PMC7420839__F9 Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis CYP26B1 ALDH1A3 RDH10 PMC8113651__F1 HIV-1 modulation of autophagy during early infection and viral non-productive bystander cell contact, and in persistent infected cells/tissues BNIP3 MTOR ARF6 DKFZp686F0183 RPTOR PEX14 PMC9653672__F6 Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells RIOK2 SP1 BAX PMC555938__F8 The pathway of metabolic shift regulatory system of yeast Saccharomyces cerevisiae in Fig HEL-S-49 PGM2 FBP1 DEHAL1 ENO2 HSF1 PMC8646547__F2 Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID‐19 disease progression TBK1 SOCS3 STAT2 IRF7 IRF9 IRF3 MYD88 TLR3 STAT1 TLR8 TLR7 TLR4 TYK2 JAK1 IRF-1 MAVS SOCS1 PMC555938__F7 Pathway of circadian regulatory system of Arabidopsis thaliana in Fig CRY1 ELF3 CRY2 PMC9069765__F8 EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway MATN3 EIF4A3 PBX3 PTX3 CTGF PMC7918761__F1 Methionine cycle facilitates re-methylation of homocysteine to methionine via methionine synthase (MTR) and betaine-homocysteine S-methyltransferase (BHMT) enzymes CTH HEL-S-61p HEL-S-182mP MTR MTRR PMC8700621__F1 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease NR2F2 BASH DDX43 PMC9655409__F8 Neuromedin S Regulates Steroidogenesis through Maintaining Mitochondrial Morphology and Function via NMUR2 in Goat Ovarian Granulosa Cells NMUR2 LATS1 GAL LATS2 STAR PMC7140344__F1 Melatonin: new insights on its therapeutic properties in diabetic complications PINK1 VEGFA SYK MTOR IRS1 BAX SIRT3 PMC8700621__F5 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease NR2F2 PITX3 GRID2 DLL4 WNT7A FGF19 DKK1 TNF INHBA PMC8700621__F4 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease TBX20 ISL2 PITX2 TBX3 TNF ARTN EGR2 PITX3 TBX1 GRID2 FGF19 ARC ATR INHBA PMC6611507__F4 Emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications EGF MYC CCL18 NOS2 PMC4992466__F1 Pathways involved in physiological and in the pathological cardiac hypertrophy of calcific aortic valve disease (CAVD) IGF1 FGF2 MTOR PMC6090955__F1 Overview of the IDO metabolic pathway IDO1 GIG8 KMO IDO2 PMC8998447__F1 Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson’s Disease ULK1 ATG12 LAMP2 MTOR HEL-S-130P DKFZp686F0183 PMC6090955__F3 Regulation, function, and targeting of IDO1 in cancer IDO1 KIT AHR APC CD80 CTLA4 MYD88 MTOR PMC2593438__F7 AKT reduces the growth-inhibitory function of TGFB1 HEMGN COMMD7 RELA FAM120C TNFAIP2 CELSR2 PMC10453526__F2 Nodes and tracks of the cholinergic anti-inflammatory pathway IL18 TNF STAT3 PMC6533757__F3 Immunosuppressive effect of the tumor microenvironment CXCL8 CXCL12 PMC4926737__F2 Disruption of postsynaptic differentiation pathway by muscle-specific kinase (MuSK) autoantibodies MUSK LRP4 PMC5901981__F3 Protein Kinase C: Perfectly Balanced PIN1 CDC37 PMC7098175__F5 Antitumor mechanism of Tan I CDK2 MTOR STAT3 BAX PMC3875633__F4 Invasion gene signaling networks (GSNs) of (A) chronic CNT-exposed and (B) chronic asbestos-exposed MeT5A cells MMP25 POSTN RELA EGFR CCR4 IGFBP2 SPDEF hEMMPRIN AURKA PMC7279300__F2 Signaling cascade of Dectin-1 NLRP3 CARD9 BCL10 RELB SYK PLCG2 PMC9603851__F1 TLR4-Pathway-Associated Biomarkers in Subarachnoid Hemorrhage (SAH): Potential Targets for Future Anti-Inflammatory Therapies TLR4 IRAK1 IRF3 IRAK4 IL6 TAB3 PMC1751079__F1 Inhibitory signals of the Toll-like receptor (TLR)4-induced MyD88-dependent signaling pathway CD14 SOCS3 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TNF DOK1 TLR4 SIGIRR SP1 RAN TRAF4 PMC8039377__F1 Molecular cascades that create epigenetic memory in HSCs CGAS RIPK3 IRF3 IL6 MYD88 TLR3 IFNG AK2 TLR4 ATM MPP3 TREX1 SYK REST JAK1 ABCA1 IL1B PMC2446520__F1 The GNB/LNB pathway and related enzymes ENG GAL PMC4357331__F1 One-carbon metabolism and methotrexateMTX enters the cell via the reduced folate carrier (RFC) by using an endocytic pathway activated by a folate receptor (FOLR [A, ƴ]) (a) (; ) RFC1 HEL-S-61p MTR SHMT1 DHFR MTRR TYMS MTHFD1 HEL-S-51e PMC5350518__F8 Proposed molecular model of VCAM-1 regulation in ccRCC-VHL–expressing cells VCAM1 RELA VHL RELB REL TNF PMC9081430__F1 Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases RUNX2 NFATC1 MSC DLX5 IL1B STAT3 PMC10919760__F3 Targeted and immunotherapeutic agents screened in GC PDX and PDO models KIF7 HGF EGFR APC LRP5 LRP6 CA3 FGFR2 TSC2 TSC1 WEE1 SUFU GLI3 SMO ATR PMC10931375__F6 miRNAs targeting different components of the WNT signaling pathway to inhibit tumorigenicity SCD APC FZD8 PMC10931375__F5 miRNAs targeting different components of the WNT signaling pathway to promote tumorigenicity APC NR3C2 DKK1 PMC4539617__F6 Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma GRPR SHH SMO RHO PMC5700476__F7 NFKB signaling pathway is activated by TLR3/TLR4 TLR4 IRAK1 TRAF6 IRAK4 MYD88 TLR3 PMC6375884__F3 A schematic representation of main processes involved in rice drought memory response MYB MYC ERF PMC9656902__F2 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways HES5 NUMB SOX2 MYC NOTCH1 GSC TUG1 CDH2 HES1 PMC9656902__F5 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways SOX2 SNIP1 PTCH1 SMO GAS1 HK2 PMC9656902__F4 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways CADM1 DNMT3B SOX4 STAT3 PMC9656902__F3 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways TH BPTF HOXA9 EHF WNT4 WNT7A EZH2 WNT2B PMC5795986__F3 Signaling pathways for melanin inhibition by NSC-CM LRP5 LRP6 DKK1 PMC7681076__F4 Proteaphagy: selective autophagy of inactive proteasomes SNX4 RPN1 CP PMC3839643__F1 Mammalian target of rapamycin (mTOR) -centric view of nutrient sensing for the induction of forkhead box P3 (FOXP3) SOCS3 MTOR STAT3 FOXP3 PMC12254190__F5 MiR-152 in hematologic malignancies, including multiple myeloma (A), AML-NPM1 (B), diffuse large B-cell lymphoma (C), non-Hodgkin lymphoma (D), chronic myeloid leukemia (E), and acute lymphoblastic leukemia (F) ATP2A2 DKK1 BRD4 PMC140043__F8 RelB is required for Peyer’s patch development: differential regulation of p52–RelB by lymphotoxin and TNF LTA RELA LTB RELB TNF LTBR PMC3839643__F3 Enzymes that catabolize or use essential amino acids CDO1 HAL BCAT1 BCAT2 AASS NOS2 ARG1 PAH HDC PMC11216939__F2 Interplay between the PI3K/AKT pathway and circadian rhythm regulators DBP PMC10670053__F1 Most common signalling pathways active in muscle and adipocytes during cancer-associated cachexia IGF1 UCP1 SMAD2 LIF TNF MTOR PMC5141640__F3 Ischemic stroke induces systemic immunosuppression mediated by several factors GC DRD2 PMC5482702__F2 Hypoxia signalling pathway in haematological malignancies EGF MYC VHL TPO PTEN PMC5326762__F2 Pathways of HIF-1A and its target genes involved in retinal neuroprotection EPO KEAP1 VHL HEL164 IRS1 ADM PMC8892079__F1 Structural basis for dysregulation of aminolevulinic acid synthase in human disease FECH UROD UROS CPOX PMC3390419__F1 Caspases and Kinases in a Death Grip BCL2 FADD BAX PMC6896486__F7 Exacerbation between G6PD dysfunction and neuroinflammation mediated chronic neurodegeneration TLR4 TNF PMC11758808__F5 Biosynthesis of ncAAs ICAM3 SEPSECS PSTK OBI1 PMC6279243__F5 Identification of Key Differentially Expressed MicroRNAs in Cancer Patients Through Pan-cancer Analysis PIK3R1 FOXO4 FGFR1 FRS2 GRB2 FGFR4 PTEN INPP5A IRS1 CCND2 AKT3 PMC2279152__F1 Apoptosis signalling pathways CASP3 APAF1 BCL2 HTRA2 FADD BAX PMC7681076__F6 Pexophagy in yeast and mammals ACBD5 TSC2 PEX6 PEX5 ATM PEX2 PEX12 PEX26 USP30 PEX3 NBR1 PEX14 PMC4212313__F1 B cell receptor signalling pathway controls B-cell fate and function BTK FYN LYN SYK PLCG2 PMC6105693__F8 Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis TIMD4 FCGR3A LCP2 VCAM1 ALOX15 CCL5 HLA-DQB1 CD74 SPIC CLEC9A PMC3655867__F2 Leptin deficiency disturbs the insulin signaling pathway JAK2/IRS/PI3K/AKT/AMPK and triggers diabetes SOCS3 STAT3 PMC6615313__F6 Metabolic context of the reconstructed σ54 regulons in Clostridiales species ETFB NHS HBD ETFA PMC9119167__F4 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins NPC1 PTMS ABCG1 ABCA1 OSBP PMC9119167__F2 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins CYP27A1 CH25H CYP46A1 CYP3A4 MVK CYP7B1 IPP PMC7288675__F2 Regulation of the microbiota in adaptive immunity IL23R PMC11034608__F7 p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model GPX4 SLC7A11 FTL PMC7269988__F2 ER stress and the activation of the three UPR pathways ATF4 EIF2A TRAF2 XBP1 PMC8720965__F4 Disorders of Sex Development of Adrenal Origin POR AKR1C2 PMC6528915__F2 Overview for the regulatory mechanisms upstream and downstream of ZEB1‐AS1 in cancer progression MMP2 CDK2 MMP9 BMI1 STAT3 BAX PMC7249489__F3 Signaling Pathways in Leukemic Stem Cells APC GSK3B LRP5 LRP6 PMC4638170__F3 Gaining insights into diabetic cardiomyopathy from Drosophila TCP1 SRI PMC7249489__F5 Signaling Pathways in Leukemic Stem Cells TGFB1 PMC7016461__F5 KEGG enrichment analysis of the hub genes TH APP SP1 PMC7249489__F2 Signaling Pathways in Leukemic Stem Cells TSC2 TSC1 PTEN DEPTOR RHEB PMC4303147__F4 Dominant negative LMP1 inhibits proliferation of CAEBV T cells TRADD IRF7 RELB PMC6412627__F1 Synthesis of triacylglycerol (TAG) HMFN0839 DGAT1 GPAT4 GPAT2 DGAT2 AGPAT3 AGPAT4 MGAT3 LPA MGAT1 MGAT2 AGPAT5 PMC6412627__F3 Regulation of the expression and cleavage of sterol regulatory element-binding protein-1c (SREBP-1c) and the transcriptional activation of the acyl-CoA:glycerol-sn-3-phosphate acyltransferase1 (GPAT1) gene IRS1 PMC6154995__F7 Heme-dependent feedback inhibition of ALAS in the heme biosynthetic pathway FECH UROD UROS CPO PMC3591604__F2 GPI anchor synthesis PIGF PGAP1 PIGO PIGC PIGW PIGH PIGM PIGK DPM2 PIGL PMC3865857__F2 Main enzymes and G protein-coupled receptors in the cyclooxygenase pathway PTGER2 PTGIR COX2 PTGFR PTGIS COX1 PTGER1 PTGS2 PTGER4 TBXA2R PTGER3 PTGDR PMC2910015__F4 General view of the species-specific regulation of histone homeostasis NPAT CDC2 SLBP PMC3865857__F1 Conversion of ω6 and ω3 series PUFA by metabolic enzymes and interaction with de novo fatty acid synthesis COX2 COX1 FADS2 SCD ELOVL5 FADS1 MLYCD ELOVL2 FASN PMC11681754__F7 Potential mechanism of LPL-RH in salvaging bone calcium loss in OVX rats TLR4 NFATC1 TRAF6 MYD88 PMC7352853__F2 Sphingolipids implicated in pulmonary fibrosis, their structure, and metabolizing enzymes CERS3 LASS1 CERS5 SPHK1 DEGS1 SPHK2 KDSR CERS2 CERS6 PMC9325518__F1 Role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma LIN28B IGF1R MYC ENO1 PTEN HEL-S-87p LIN28A MTOR HEL-S-162eP PMC8327449__F3 PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression SMAD2 TGIF1 SMAD4 PMC7352853__F6 Role of lysophosphatidic signaling via lysophosphatidic acid receptors in pulmonary fibrosis SMAD2 SMAD4 RHO LPA TGFBR3 HEL-S-14 PMC3785471__F2 Host Response to Respiratory Bacterial Pathogens as Identified by Integrated Analysis of Human Gene Expression Data NFKBIA CS PIAS2 MDM2 SF1 SAE1 RANBP2 UBE2E3 HSF2 SP3 SP100 SUMO1 PMC9508608__F1 Methionine restriction - Association with redox homeostasis and implications on aging and diseases HEL-S-61p SRM SMS PMC9584741__F4 lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway NOVA2 C1orf167 GATD3 KY PDGFRA FLT4 KLF14 LPO TSHZ2 RYR2 GABRA4 TC2N RASGRP3 ABCC9 MUC20 CRB2 AGXT2 CAMK2A PMC7098175__F3 Antitumor mechanism of CT TSC2 BAD IGF1 CCND1 HIF1A HEL-S-133P RHEB HK2 STAT3 SIRT3 PMC7098175__F2 Antitumor mechanism of Tan IIA BAD FOXM1 MMP9 EIF2A NOTCH1 CTLA4 MTOR SKP2 STAT3 BAX PMC7397204__F2 PI3K/Akt/mTOR signaling and its interaction with PTEN TSC2 BAD TSC1 CDK2 MDM2 RAD51 PTEN JAK1 IRS1 CENPO PMC11042502__F2 Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD ACADL ACADS CPT1A HADHB ACADVL CPT2 ACAD9 ECHS1 ACADM CD36 PMC9203892__F3 TIGIT as a Promising Therapeutic Target in Autoimmune Diseases APC CD80 TIGIT CD226 PMC8233504__F7 Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila RICTOR TSC1 STUB1 MYC CDC37 FMR1 DENR RHEB MOB4 PMC11040290__F1 Emerging role of galectin 3 in neuroinflammation and neurodegeneration IGF1 HEL-S-28 CD44 MERTK IFNGR1 PMC4061222__F1 Roles of Wnt5a in cancer metastasis- (A) promoting and (B) suppressive processes TLR4 ROR2 SIAH2 ARF6 PMC2268796__F6 The signaling pathways regulating cell cycle and differentiation in tumor cells in response to shear stress RUNX2 CCNB1 CDC2 SMAD1 DKFZp781O1323 PMC4109802__F2 Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration FGFR1 FGF2 CD200 PMC9305269__F4 Effect of a Functional Phospholipid Metabolome-Protein Association Pathway on the Mechanism of COVID-19 Disease Progression PC CER1 CERK PMC5578430__F1 Innate immune escape by Dengue and West Nile viruses TBK1 CGAS IRF7 IRF3 TRIM25 MAVS PMC8278114__F6 Pro‐inflammatory signals induce 20A‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal TLR4 FOS TRAF6 MYD88 JUN PMC7729028__F4 MEKK3–MEK5–ERK5–KLF2/4 signalling pathway ADAMTS4 TLR4 KRIT1 KLF4 KLF2 IL1B CDC42 PMC4632280__F7 RAC3 regulates cellular senescence and aging RAC3 MTOR SIRT1 PMC1698527__F10 Model for the transduction of DNA damage signals to the splicing machinery TAF1 ATM TAF3 ATR TAF4 PMC9684653__F3 Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma TSC2 ATM MDM2 MTOR AURKA PMC4384662__F4A PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting BCR EGFR CD40 PTEN RAC1 CDC42 CD19 PMC5640931__F2 The mathematical model PC APC PMC2964935__F5 PAR Proteins: Fundamental Players in Animal Cell Polarization TIAM1 NUMB RHO PTEN INSC PMC3196148__F9 Working model for the ATF4-dependent and c-JUN-dependent AA signaling pathways ATF4 ATF2 EIF2A PMC9445622__F1 Akt isoforms in the immune system CD80 PMC3209670__F3 mTOR signaling pathway affected by pollen feeding or varroa parasitism RICTOR TSC1 BRAF ELF4 RHEB PMC4595834__F7 Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4Beta-S-aromatic heterocyclic podophyllum derivatives display antitumor activity ATM ATR FADD PMC7177758__F1 JNK (C-Jun N-terminal kinase) substrates that regulate the mitochondrial apoptotic pathway BAD BMF ITCH PMC7177758__F3 Positive feedback loops in apoptosis CCND1 PMC9508608__F3 Methionine restriction - Association with redox homeostasis and implications on aging and diseases FGF21 MPO ATF4 MTOR NR1C1 SIRT1 NQO1 PMC4908701__F5 Curcumin regulated signaling networks SDCBP NRF1 TMX1 PAK6 TNK2 CRKL PRKCA ANKS1A FYN MAPK12 PTK2B MAPK1 ROCK2 BAG3 PCTK1 ERBB3 ARHA HRAS CRK CBL HEL-S-80p PKP4 LYN GRB2 IL6ST EPHA2 SHC1 PXN TGFB1 EPHB2 PIK3R2 CDC42 STAT3 PMC7899164__F6 MitomiRNAs interactions with mitochondrial encoded genes either positive or negative suggestively COX3 COX1 ATP6 CYB PMC3579383__F1 Myelin-derived neurite growth inhibitors, their receptors, and intracellular signaling pathway ARHA LINGO1 PMC6698799__F4 Proposed molecular mechanism of regulation of the pyrin inflammasome HEL-S-62p IL18 PKN2 RHO PKN1 PMC4102778__F3 GSK-3 as potential target for therapeutic intervention in cancer ULK1 PTEN EIF4E MTOR DEPTOR IRS1 RHEB TSC2 RICTOR TSC1 GRB2 RPS6 EIF4B PMC11506062__F2 Major metabolic pathways at work within cancer cells TIGAR ACACA GLS2 ENO1 ACSS2 MTOR HMGCR RHEB HEL-S-162eP SLC7A5 SCD HEL107 FASN PMC11506062__F1 Comparison of the major metabolic pathways in (A) normal and (B) cancer cells SLC7A5 MTOR PMC4102778__F7 GSK-3 as potential target for therapeutic intervention in cancer SUFU PTCH1 IGF2 GLI3 CCND1 RAB23 BCL2 SMO PMC3880216__F5 Schematic diagram BAD GSK3B BAX PMC6826683__F10 Strategies for therapeutic intervention of cancer involving FADD PLK1 CCNB1 CCND1 FADD AURKA PMC7830297__F1 TLR4 signaling pathway TBK1 TLR4 TRAF3 TRAF6 IRF3 IRAK4 MYD88 MAP3K7IP1 TIRAP TAB3 PMC6698799__F3 Proposed interaction model of Yersinia pestis effectors, Yops, with the pyrin inflammasome PKN2 MVK RHO PKN1 PMC4064057__F3 Genotype-specific steatogenic pathways associated with hepatitis C virus infection SOCS3 PTEN PMC2726954__F2 Quest for genetic determinants of human longevity: challenges and insights IGF1R IGF1 PTEN SGK1 PMC7028093__F2 Notch signaling pathway NOTCH2 MAML1 NOTCH4 NUMB RBPJ MAML3 JAG2 MAML2 LFNG NOTCH1 NOTCH3 PMC3860372__F1 Metabolic Homeostasis: HDACs Take Center Stage HNF4A SIK3 CRTC2 SIK1 PMC8095380__F7 Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology MYB NOG CHUK BAD PIK3CA RORA HRAS PMC6460806__F2 Interactive signaling pathway of EGFR-PI3K-mTOR EGFR RALA RALB RHO PTEN RHEB PMC3981572__F9 Integrative model of the physiogenomic adaptations in adipose and liver tissue induced by energy overfeeding during the last 45 days of pregnancy FGF21 SOCS2 CS ANGPTL4 ACACA ADFP CRAT NR1C1 MTTP IGFALS RXRA ACOX1 DGAT1 APOB IGF1 ACADVL GHR MLYCD CROT RORA NCOR2 PMC9195137__F3 AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications EGFR SRC TF PMC6068130__F1 Tryptophan (Trp) catabolic pathways IDO1 HEL-S-90n KYNU KMO PMC9123149__F2 Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock ENPP1 ADA PMC6923668__F1 Mechanism of mutant CALR-induced MPN and approaches for therapeutic targeting APC HEL-S-99n MPL PMC5773610__F7 Mechanism of anti-allergic and inflammatory effect of quail egg on the food allergy induced EoE like disease alergic reaction IL15 IL6 TSLP PMC10886582__F3 Pathways related to activation of pyroptosis NLRP3 NLRP1 GSDMD PMC5640931__F1 Simplified scheme of liver architecture and Wnt/ Beta-catenin signalling PC APC PMC5883082__F1 Programmed cell death protein 1 (PD-1) mediated intracellular signaling events during T cell activation LCK GRB2 CD80 PMC7000431__F1 Human and mouse bile acid synthesis and conjugation CYP27A1 CYP8B1 CYP7B1 PMC5557697__F3 Model depicting the Cdc42-mediated regulation of EGF receptor interactions with c-Cbl EGF EGFR CDC42 CBL PMC6492897__F2 Ingenuity pathways analysis (IPA) of ASS234 (5 μM) treatment GCLM EPHX1 KEAP1 GCLC HEL-S-107 UBB TXN BACH1 MAF HEL-S-94n USP14 ATF4 GPX2 CCT7 HEL-75 UNK PPIB VCP JUN CLPP PMC10886582__F4 Necroptosis signaling pathway RIPK1 TRADD CYLD RIPK3 MAP3K7IP1 TRAF2 FADD MLKL PMC4128536__F4 STRING analysis of pathway enrichment and interaction in the altered mRNA in rat ARDS MT3 PSMA4 APC LCN2 TSPAN8 FGFR4 S100A9 EIF2AK1 HEL-S-128m CES3 HEL-S-32 LIM2 TIMP1 GABRB1 ACO2 IGFBP6 GP1BB S100A4 GNRH1 RAMP2 LCT PMC5067484__F1 Reelin signaling pathway in the developing cortex VLDLR GSK3B DAB1 CDH2 MTOR CRK CRKL PMC4809675__F1 TNF biology, pathogenic mechanisms and emerging therapeutic strategies TRADD TNF TRAF2 MLKL PMC3251560__F7 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes RORC ADIPOR2 TAOK3 INCENP ARHGEF3 TMF1 PRR14 POFUT1 FER HNF4A LEPR RORA TRIM24 MKI67 STAT3 PMC11595909__F2 Signaling mechanism of IGF-1 upon binding to IGF-1 receptor (IGF-1R) BAD IGF1R IGF1 MTOR PMC11595909__F1 Effects of BDNF and NGF on the cell signaling processes that potentially lead to cellular effects with the end results of neuroregeneration or neurorepair NGF BDNF PMC3251560__F9 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes DKFZp686P0251 SURF2 DKFZp313J0816 MAX PROCA1 TRPS1 PSME4 MYOG PMC3251560__F8 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes SLC1A1 MALL ADRM1 TUBG1 MAGI1 CBX4 PCGF2 PMC4828918__F1 Figure demonstrates the wide array of interactions present in the Wnt signaling cascade EGFR APC GSK3B LRP5 LRP6 PLAGL2 MTOR RHEB HES1 AXIN1 SHH SMO AXIN2 PEG3 PMC8718055__F6 Inhibition of the NLRP3/IL‐1B axis protects against sepsis‐induced cardiomyopathy NLRP3 IL1R1 IL1B PMC11595909__F3 LIF signaling mechanism upon binding to LIF receptor that is constituted by LIFRB and gp130 heterodimer LIF MTOR PMC4427718__F3 Biological network capturing the immune response and the metabolism of glycosaminoglycan and sphingolipid revealed from Ingenuity Pathway Analysis® (IPA®) GNS HEXA GALNS FUCA1 BATF GNPTAB CD27 LRRC26 APP LITAF ARHGAP21 IL4 ACR PMC6879915__F1 Apoptosis pathway APAF1 FADD PAF1 BAX PMC7844024__F8 Differential NFKB pathway activation by 65–79*SE and 65–79*PE under M1 (A,B) or M2 (C,D) polarizing conditions EGR1 RELB MYC TEC CEBPA HIF1A STAT1 NFKBIA NFKB1 RELA SP1 REL IRF-1 STAT3 PMC6582183__F2 Schematic portrays crosstalk between miR29 family and various signal transduction pathways involved in pathogenesis of Diabetic Nephropathy KEAP1 DPP4 WNT1 PMC5280013__F8 miR-146a plays a critical role in limiting the inflammatory response to ischemia-reperfusion TLR4 IRAK1 PMC9570317__F1 Advances in Anti-Cancer Activities of Flavonoids in Scutellariae radix: Perspectives on Mechanism SOX2 CDK2 GSK3B CCNB1 CCND1 CDK4 PTEN CDK6 CCND2 PMC2714185__F3 Major regulatory steps in the process of DNA damage response (DDR) PML ATM BRCA2 ATRIP MDC1 RAD50 RAD52 RAD51 ATR MRE11A BRCA1 PMC8975741__F8 The role of TSPAN6 in the regulation of signaling pathways in tumorigenesis EGFR SCRIB TSPAN6 PMC2714185__F1 Role of ATM in cellular responses FANCD2 ATM CDK2 MDC1 MDM2 RAD50 MRE11A BRCA1 PMC6667928__F3 Therapeutic strategies are involved in heme metabolic pathway HP CD163 ABCG2 PMC6667928__F2 Pivotal functions of the molecules in heme metabolic pathway in inflammation NLRP3 TLR4 SYK HEL-S-92n PMC4594483__F2 TGFB signaling SMAD2 TGFBR1 SMAD4 RHO TGFBR3 PMC7689298__F10 Proposed model of the involvement of TREM2 in the IL-4-induced anti-inflammatory response CSF1R TLR4 C1QA IGF1 AIF1 AP1B1 JAK3 ITGAX MYD88 DKFZp686L24211 TNF ARG1 PMC3427140__F4 Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function APC GSK3B KLF4 PMC8204012__F1 New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases NLRP3 IL18 TFEB IL1B PMC7999361__F2 Photoperiodic flowering in Arabidopsis, a long-day plant, and in rice, a short-day plant CRY1 EHD1 CRY2 RFWD2 PMC8701046__F1 Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication PALB2 SWSAP1 BRCA2 RAD51D BARD1 RAD51 XRCC3 RAD51B BRCA1 RAD51C PMC9411814__F6 Investigation of the mechanism of the anti-cancer effects of Astragalus propinquus Schischkin and Pinellia pedatisecta Schott (A&P) on melanoma via network pharmacology and experimental verification BAD BCR MDM2 CYC1 PTEN RAC1 IRS1 RBL2 CD19 PMC4878678__F1 Genes in the MAP kinase signaling pathway (MAPK signaling pathway) identified using the KEGG-based pathway visualization tool CD14 MAX EGFR ECSIT TRAF2 JUN PMC5711814__F2 Non-canonical regulation of HIF-1A stability HEL-S-62p MDM2 RHO PTEN HEL-117 MTOR PMC6511038__F3 Enrichment analysis of genes transcriptionally related to morphometric similarity ITPR2 NPY1R OPRM1 ADRA2C S1PR1 HTR7 PTGER3 DRD4 CNR1 PDYN PLCB2 DRD5 NTSR1 EDNRB HTR1A GNG2 PMC5536018__F4 The alternative splicing and immune function of RLRs-mediated signaling pathways in response to viral infection in teleost fish IRF7 TRAF3 IRF3 MAVS PMC5463089__F2 Ubiquitination mediates the NF‐KB activation and nuclear translocation FBXO4 SUMO2 BRAF MDM2 CCND1 HIF1A TRPM1 SKP2 SUMO1 PMC6314914__F3 Proposed PD-1 & PD-L1/L2 intra-cellular signaling between T cells and/or macrophage/monocytes, among others (e.g CD80 PMC8553822__F2 TLR signal transduction TBK1 TANK TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 MAP3K7IP1 TLR10 TLR3 TLR8 PDC RIPK1 TLR7 TLR4 IRF-1 TIRAP MAL TAB3 PMC8782664__F1 LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring TLR8 CD14 TLR7 TLR4 TLR9 TRAF3 TRAF6 IRF3 MYD88 ACE2 TLR3 MAVS PMC5587604__F5 Hydroquinone suppresses IFNB expression by targeting AKT/IRF3 pathway IRF3 MYD88 IL1B PMC4716143__F3 Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection HEL-S-62p CS C4B_2 CRP PMC2779044__F4 Model describing the regulation of protein synthesis by AMPK, Ca++ and Akt -signaling pathways TSC2 EEF2K TSC1 EEF2 EIF4E RHEB PMC5078051__F6 Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium PLK1 FOXM1 BCL2 AURKB PAX8 PMC8742179__F6 ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis ZNF292 SKP1 RBX1 SKP2 PMC7073055__F1 Pathogenetic mechanisms in extranodal NK/T-cell lymphoma (ENKTL) IL10 ITK IL9 LCK ZAP70 BCL2 IL2 JAK3 IFNGR1 LAT ELL PMC8994689__F3 Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases NOX4 LPO RPE PMC8220134__F6 Early Growth Response Family Members 1–4 in Prognostic Value of Breast Cancer PARP14 EGR1 NAB1 NAB2 NFATC1 FOS IER2 LHB NFATC3 CEBPB CD69 HOXB2 EGR4 NFATC2 EGR2 FCER2 GDF15 SYN1 JUNB ABCB1 PMC8399174__F1 H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans PHKB ARHA NAPA HMFT1766 CDC42 PMC10522874__F2 Mature white adipocyte plasticity during mammary gland remodelling and cancer SUFU APC GSK3B SMAD6 SMAD4 SMO SMAD1 DKFZp781O1323 PMC6470985__F3 Regulation of the mucus production by MAPK signalling MUC4 EGFR SRC JUND MYD88 SP1 TGFA FOXA2 PMC5432547__F4 Action network of predicted targets of miRNAs overexpressed in GML mice stomachs TP53INP1 EGR2 PTEN PMC3911547__F12 Schematic diagram depicting the diverse outcomes of KSHV-induced 5LO and LTB4 in ECs and the consequences and roles of KSHV in viral pathogenesis SRC EPHA2 PMC7457719__F6 Scheme illustration for Au4.5-induced NLRP3 inflammasome activation NLRP3 DKFZp686F0183 IL1B PMC4269192__F1 Type 3 deiodinase expression on Warburg phenotype HIF1A MXI1 HEL-S-133P PMC10888202__F6 Comparative analysis of DEGs at different growth stages HEL-S-68p HEL-S-162eP PMC11757137__F1 M5C modifications in immune signaling regulation TBK1 CGAS TLR5 GPX4 TLR9 IRF7 TRAF3 IRF3 NSUN5 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TREX2 NSUN2 MAVS PMC10941471__F7 Graphical abstract SMAD2 LPA PMC5190135__F1 Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development EGF KEAP1 MMP9 HEL-S-8a TEF CCND1 STAT3 PMC8195365__F8 Tentative mechanistic model for MERS-CoV-induced protective innate immune responses in alpaca respiratory tracts IL10 IRF7 CXCL10 IRF3 IL6 CCL2 MX1 IL15 STAT1 ISG15 NLRP3 OAS1 IL1B CCL3 PMC10150574__F3 Signaling through the phosphatidylinositol 3-kinase (PI3K)/AKT pathway BAD EGFR GSK3B MDM2 GRB2 SRC PTEN RAC1 MTOR CDC42 STAT3 PMC6945844__F3 High Flux Through the Oxidative Pentose Phosphate Pathway Lowers Efficiency in Developing Camelina Seeds HP CIT MAL PMC7681028__F6 Functions and pathways of the type II MAGEs, MAGE-F1 and -L2 CRY1 VPS35 RTEL1 FES MMS19 LEPR MAGEL2 TRIM27 VPS29 PMC8841513__F5 CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation NLRP3 IRF3 HIF1A TF MAVS PMC6627878__F2 Kinase signalling pathway IL7R BCL2 JAK3 PTEN JAK1 MTOR PMC11202056__F8 STRING pathway analysis depicting protein–protein interaction (PPI) networks NAPSA SCIMP MOS MYOCD PLA2G4D HELT ERICH5 TMEM114 STAC2 DKFZp686L24211 REG3G CXCL13 ROBO3 GPR174 PRSS22 ADAM33 HTRA4 ESPN NPY2R INHBA PMC4412965__F3 Proteins involved in chromosomal fragility GEN1 FANCD2 ATM BLM HUS1 RAD51 ERCC1 POLN ATR WRN BRCA1 PMC4469326__F4 JAK-STAT signalling pathway PIM1 EPO IL6 CBL PMC2715808__F8 Regulation of mTORC1 signaling by mTOR S1261 phosphorylation MTOR RHEB MLST8 PMC7218496__F9 Mechanism of AA on attenuating hypertrophic and fibrotic differentiation RUNX2 ACAN COL2A1 COL1A1 COL10A1 SOX9 PMC4469326__F3 TNF signalling pathway TH TRADD IL6 TNF CASP10 NOD2 CASP3 EDN1 TRAF1 TRAF2 FADD MLKL SELE ITCH PMC4469326__F2 Toll-like receptor signalling pathway coverage CD14 CTSK TLR9 IRF7 TRAF3 TRAF6 IRAK4 IRF3 RAC1 MYD88 TLR3 LBP CD40 CD80 FADD TIRAP PMC10742271__F4 Signaling pathway involved in the osteogenesis process due to Mg effect MAGT1 NFATC1 MSC CREB1 TRPM7 PMC8294190__F5 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? TNF STAT3 FOXP3 PMC8294190__F2 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? EGF EGFR HDAC2 TGFBI PMC8294190__F1 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? TRAF6 IL17RB IL17RC PMC8773363__F3 Atoh8 in Development and Disease SMAD6 SMAD4 ATOH8 SMAD1 DKFZp781O1323 PMC9242402__F4 Metabolic Regulation of Hematopoietic Stem Cells GOT2 BCAT1 GLS PMC9335447__F5 MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study ME1 FECH EGFR PNP PMC8580782__F0 Erythrocytosis: genes and pathways involved in disease development CREBBP EPO MMP9 VHL HEL-S-133P EGLN1 HEL-S-68p PMC8539415__F1 Metabolic Perturbation and Synthetic Biology Strategies for Plant Terpenoid Production—An Updated Overview PTS LPP IPP PMC6158481__F4 WNT/Beta-catenin signalling APC GSK3B LRP5 LRP6 PMC5384027__F1 Schematic of the DNA repair pathway RNF168 RNF8 RIF1 FANCD2 ATM MDC1 RAD51 BRCA1 PMC7893585__F9 Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway MSLN DKK1 PMC4800296__F1 Simplified representation of the PI3K-AKT-mTOR pathway in pancreatic neuroendocrine tumours TSC2 RICTOR TSC1 PTEN GRB10 MTOR IRS1 RHEB PMC7894021__F6 Epidermal growth factor (EGF)‐mediated high‐mobility group protein A2 (HMGA2) transcription in hepatocellular carcinoma (HCC) cells HMGA2 EGF EGFR PMC6533250__F7 Wnt/Beta-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast FGF3 FGF10 GSK3B CCND1 PMC3969803__F3 Summary of the mechanism of several important drug candidates for anti-cancer metabolism therapies SCD ACLY HEL-S-133P UCP3 UCP2 HK2 FASN PMC5845388__F5 Germinal center pathway in systemic lupus erythematosus TH PC GC PMC3969803__F2 Summary of key changes in cancer metabolic reprogramming ME1 HEL-S-26 SCD ACLY HEL-S-133P UCP3 UCP2 HK2 FASN BAX PMC3167094__F1 New Hormonal Therapies for Castration Resistant Prostate Cancer STS AKR1C1 HSD17B2 HSD17B3 AKR1C2 HSD17B10 UGT2B15 PMC6487735__F1 Schematic representation of the linkage between SAMe, SAH, sarcosine metabolic pathway and methionine cycle HEL-S-182mP PIPOX PMC5009710__F6 Simplified model for extracellular phytohormones that regulate enzyme-encoding genes or TFs in phytohormone biosynthesis by signal transduction pathways MYB MYC ERF TF PMC3864579__F1 CD4 T-cell immunotherapy for chronic viral infections and cancer PC BCR APC CXCR5 CD40 IL4 PMC9170610__F3 Calcineurin in development and disease ITGB3 TRPC6 RAC1 CDC42 PMC9101307__F3 New Player in Depression: MiRNAs as Modulators of Altered Synaptic Plasticity LEF1 WNT5B BDNF SIRT1 PMC8807567__F3 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance WEE1 FBXW7 PMC8807567__F2 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance KEAP1 GPX2 RBX1 IL1B PMC8807567__F1 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance DBP PMC4624764__F8 Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells PITX2 SMAD2 MYOCD TGFBR1 SMAD4 GATA6 NOX4 ARHA mkl1 MRTFB KLF4 SP1 SMAD1 DKFZp781O1323 PMC8589187__F1 Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing IGF1 SRM SMO AMD1 ASL PRL PMC8348955__F11 Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury FGF21 FGFR1 FGF19 FGFR4 MTOR NR1C1 CYP7A1 PMC4615225__F6 Overview of regulatory networks in which miRNA/target pairs function during the rice response to fungal elicitors AGO1 AGO4 ERF PMC3672663__F1 The canonical Hedgehog signalling pathway in mammals HHIP BOC SUFU SMO GAS1 PMC9620658__F1 Targets of aspirin in bladder cancer: bioinformatics analysis CASP3 NFKBIA EDNRA PTGS2 MYC CCND1 PCNA PMC4406394__F2 JAK2 Inhibitors: What’s the true therapeutic potential? EPO MTOR PMC6088189__F1 Tetraspanin roles during HIV-1 infection CD9 CD63 CXCR4 TSPAN7 ADAM10 CD81 PMC9045983__F6 Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway BATF3 SETDB1 FOSB PMC7025498__F11 Celastrol-suppressed VM and angiogenesis in glioma VEGFA MTOR EPHA2 PMC2850885__F7 Proposed model of a EGFR/Beta-catenin/cyclin D1 signaling pathway in oral cancer EGF APC EGFR CCND1 HDAC1 PMC4926181__F2 HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ RNF8 MAP3K7IP1 PMC8877852__F1 Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor PmMYB7 in Pinus massoniana Lamb. CAD AMT PMC8675329__F3 Novel Insight Into the Fate of Cardiomyocytes in Ischemia-Reperfusion Injury: From Iron Metabolism to Ferroptosis TH KEAP1 SLC7A11 ATF4 EIF2A ARF4 SLC3A2 CHAC1 PMC11278107__F3 Antifibrotic activity of EchA in SSc model CD163 CCL18 NOS2 CD68 PMC2785475__F4 Expression-Based Network Biology Identifies Alteration in Key Regulatory Pathways of Type 2 Diabetes and Associated Risk/Complications BAD NR3A2 EGFR IRS1 EDN1 FER FYN BCR IL3 PTPN1 GRB2 SRC DVL2 JAK3 IL4 ARAF PMC8630233__F6 Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity TLR4 IRAK1 LBP TRAF6 IRAK4 MYD88 PMC2774576__F1 Diagram illustrating the biosynthetic pathway of n-3 and n-6 fatty acids from dietary precursors FADS2 FADS1 HEL-S-5 PMC6345611__F1 B-cell receptor (BCR) signaling pathways important to the pathophysiology and treatment options for chronic lymphocytic leukemia (CLL) BTK BCR BASH LYN GRB2 SYK PMC8724284__F4 Wnt/Beta-catenin signalling: function, biological mechanisms, and therapeutic opportunities TNIK APC CRP GSK3B ROR2 ROR1 PMC11625809__F3 LncRNAs are involved in the AR pathway to regulate enzalutamide resistance MDM2 USP22 PMC11625809__F2 LncRNAs are involved in the neuroendocrine secretion of prostate cancer CBX2 STAT3 PMC11625809__F1 Neuroendocrine Evolution and drug resistance mechanism of prostate cancer PMC7472859__F8 The key proteins related to the PPI-PD network obtained as common proteins with the highest score through five ranking methods TH MAPK8 ALB INS MAPK14 CXCL8 PTEN UBB HMOX1 UBC TLR4 RPS27A APP HEL-S-44 MAPK1 SNCA IL10 FGF2 MMP9 VEGFA ADRB2 RAC1 IL6 PS1TP5BP1 HEL-S-162eP CASP3 NFKB1 AVP PIK3CA ADAM10 BDNF CDC42 PMC10962462__F2 Novel molecular targets in endometrial cancer (EC) CGAS TSC1 WEE1 ATM EGFR CCNH CDC2 MTOR ATR TF CDK7 MYT1 PMC4279155__F1 The heme biosynthetic pathway and aspects of its regulation in hepatocytes ALAS1 FECH UROD HMBS HMOX1 MX1 PMC5830900__F1 Role of the TGFB family in mammary gland development and maturation HGF IGF1 MSX2 PMC3161159__F1 Retinoid metabolic pathway RARA RARB CYP26A1 LRAT CYP26B1 CYP26C1 ALDH1A3 PMC7920342__F8 Schematic drawing of the role of Lhx6 in regulating root furcation development DSPP LHX6 WNT10A AXIN2 PMC7776261__F6 Proposed model to illustrate the regulation of quiescence stage of persisting chronic myeloid leukemia (CML) leukemic stem cells by their microenvironment BMP2 BMP4 STAT3 PMC9605185__F3 Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer BCL10 SUFU EVC2 SMO ARHA RAC1 ADRBK1 PMC6287140__F4 Putative inhibitory pathway of Ac-ME in mediating the inflammatory response TLR4 SRC SYK IL6 MYD88 IL1B PMC2921612__F1 Molecular Diagnosis and Therapy of Kidney Cancer EGFR VHL MTOR TGFA PMC11954244__F2 Isoflavone biosynthetic pathway PTS GIG8 PPY IPP PMC8106074__F1 Hepcidin pathway and the regulation of body iron homeostasis BMP6 HAMP BMP2 TMPRSS6 HFE JAK1 TFR2 STAT3 PMC3465249__F3 Changes in hepatic gene expression in the KEGG PPAR signalling pathway in SNEB compared to MNEB cows UBC PLTP UCP1 HEL-S-28 LPL PMC4467136__F5 Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 HES5 NUMB DTX1 HES1 PMC7965852__F2 LncRNA-mediated lineage transition EGF IGF1R HGF HBEGF IGF1 BCL2 REST TUG1 EZH2 CXCL12 CDH2 TGFA SERPINB2 PMC4640886__F1 Etomidate on the Steroidogenesis of Rat Immature Leydig Cells SCARB1 HSD3B1 CYP11A1 LHCGR HSD17B3 CYP17A1 STAR PMC7404231__F2 Stress-response mechanisms UBL5 ATF4 EIF2A PMC4619386__F6 DDVP profoundly affects energy metabolism GYS2 SDHC GOT2 PHKB ACACB GSK3A SUCLG2 HEL107 SDHA HEL-S-281 PMC7197780__F1 Effect of ovarian stimulation on the expression of piRNA pathway proteins MAEL PNLDC1 TDRD1 HIG-1 PMC3157546__F7 The role of TAK1 signaling in bone metastasis COX2 MMP9 TNF MAP3K7IP1 PMC7531533__F1 Schematic showing how retinoids regulate thermogenic gene expression in adipocytes UCP1 ADRB3 PMC6985464__F3 Molecular signaling in poultry feather follicle and feather development APC GSK3B CCND1 SMO PMC5209283__F7 Stat3 and C/EBPB synergize to induce miR-21 and miR-181b expression during sepsis CCND1 CDK4 STAT3 PMC8747952__F1 An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19) SOCS3 ADAM17 STAT3 PMC3575850__F8 Hypothetical model for functional redundancy of Rad18 and NHEJ in responding to oxidative DNA damage during G1 SSB POLN RAD18 PCNA PMC7977448__F2 Inflammasome activation NLRP3 NAIP NLRC4 NLRP1 RHO AIM2 IL1B PMC5419167__F7 Genomic and nongenomic cross talk of the GnRHR and GR signaling pathways on the GnRHR promoter in LBT2 cells GNRHR GRIP1 JUN PMC1782438__F2 Role of adaptors in T-cell signalling ITK VASP FYN LCK GRB2 LAT CDC42 PMC7738984__F8 Identification of the target genes and construction of its dynamic regulatory network HEL-S-62p EGF GNG13 HP LCK EGFR GNGT2 TACR1 SAA1 HTR2A ADCY8 PMC10030840__F2 Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases AGA NTHL1 ERCC5 PMC7298284__F1 Cyclin B1‐MAD1 interaction promotes checkpoint signaling at kinetochores MCC NUF2 KNTC2 APC CCNB1 TPR CDC2 KNL1 PMC7690154__F1 MiRNA biogenesis and regulatory signaling pathways DGCR8 E2F4 SMAD2 DROSHA SMAD4 ARHA PTEN RAN PMC9669513__F2 Effect of oncogenic activation of RAS signaling in OC EGFR GRB2 MTOR STAT3 PMC7935792__F2 Antigen presentation process CD40 CD80 PMC7823159__F7 Drosophila Activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes TSC2 RICTOR TSC1 SMAD2 RHEB PMC6593070__F7 Curcumin mediated inhibition of cell growth via inhibition of AKT signaling and activation of mitochondrial apoptotic pathway HEL-S-62p C9 BCL2 PTEN FOXO1 PAF1 BAX PMC6031772__F1 Arsenic Trioxide and Thalidomide on Angiogenesis and VEGF in Leukemia PTEN MTOR PMC8824753__F2 Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression NLRP3 TLR4 IL13 TIGIT S100A9 MYD88 PANX1 AIM2 IL1B CEACAM1 PMC6317254__F2 Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma UCP1 SLC25A27 UCP2 COX2 NDUFB10 SURF1 SDHD NDUFS8 SDHA SDHB NDUFS4 SDHC NDUFB9 NDUFB2 CYB ND6 NDUFB4 COX3 ND3 ND1 ND2 NDUFB7 NDUFA10 ND4 UCP3 PMC11609686__F1 Illustration shows the suggested role of SARS-CoV-2 in EMT induced by ROS in cancer cells NLRP3 NRP1 MTOR ACE2 AXL PMC12104694__F1 Indole‐3‐acetic acid (IAA)‐mediated signaling pathways in epithelial and endothelial cells USP40 PAPSS2 TLR4 AHR TEC MYD88 MUC2 EPHB2 PMC10100231__F7 Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGFB1 signaling SMAD2 SMAD4 TGFB1 PMC7605689__F2 netboxr: Automated discovery of biological process modules by network analysis in R PIK3R1 RB1 CDKN2A SNAPC3 IFNG KDR A2M TBP FRS2 MDM2 IFNA2 IFNW1 LYZ DOCK1 IFNAR1 NCAM1 CRK SH3GL2 CDKN2B HEL-S-100n EPHA3 IFNA1 DKFZp781B1423 CDKN2C EGFR PTEN CCND2 PIM1 PTPRB FGF23 AVIL PTPN11 CDK4 HEL-S-77 NUP107 KLF6 CCT6A TAF1 KIT MPDZ IFNB1 NR1C1 SPRY2 CBL PIK3C2B SNRPE CNTN2 ERBB2 STAC3 PIK3CA PTPRE AGAP2 PMC4146704__F6 MIF-CD74-Lyn signaling cascade during osteoclastogenesis NFATC1 GAB2 LYN CD44 SYK CD74 PMC7662069__F8 MiR-497-5p regulating osteo/odontogenic differentiation of SCAP SMAD2 SMURF2 SMAD4 PMC7147366__F3 Key metabolic pathways (glutathione metabolic pathway) involved in the interaction between GNPs and HDFs and the key metabolites involved LAP3 PMC3426490__F2 Flow chart showing the genes involved in TLR signaling pathway CD14 CD40 IL6 FADD GLA TLR3 TIRAP PMC8915851__F1 Of NRF2 Pathway in Preventing Developmental and Reproductive Toxicity of Fine Particles MAF KEAP1 NQO1 PMC6723309__F1 Adenovirus-directed innate immunity through nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) CXCR1 CGAS TLR4 EGFR IL8RB IRF3 TNF PMC8200290__F4 Up-regulated genes in advanced basal cell carcinoma overlaid on the KEGG “extracellular matrix–receptor interactions” pathway CD47 CD44 VWF CHAD CD36 PMC9485571__F1 Uncovering incontinentia pigmenti: From DNA sequence to pathophysiology IL1A IKBKG RELA IL1B PMC8200290__F1 Up-regulated genes in basal cell carcinoma compared with normal skin, overlaid on the KEGG “Pathways in Cancer” pathway KL APC CRKL MAL PMC5436295__F3 MAPK signaling pathway INA EGF NGF MOS TES EGFR TRAF6 TNF NLK NF1 MAX ECSIT RAF1 BDNF TRAF2 MEF2C PMC4364530__F1 MITOCHONDRIAL DISEASES PART I: MOUSE MODELS OF OXPHOS DEFICIENCIES CAUSED BY DEFECTS ON RESPIRATORY COMPLEX SUBUNITS OR ASSEMBLY FACTORS NDUFA5 NDUFS4 ND6 NDUFS6 SCO2 COX1 COX17 COQ9 COX10 SURF1 SDHD UQCRFS1 PMC5985952__F7 Sequential activation of polyadenylation during oocyte maturation in Xenopus MOS PUM2 PGC EIF4E MYT1 PMC8040310__F8 The proposed molecular mechanism highlighting the role of betulinic acid in the pathophysiology of SCI and subsequent neurological recovery NLRP3 IL18 TFEB MTOR IL1B PMC8965895__F2 Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways LRP6 DKK1 PMC7734336__F7 Elements of the SPINK1 pathway are involved in PDAC progression PRSS2 SMAD2 TGFBI TMPRSS15 PMC6723309__F2 Hypothetical model for adenoviral regulation of stress-induced EGFR signaling through NFKB TSG101 PIN1 EGFR RILP PMC8440965__F5 Acute Impacts of Different Types of Exercise on Circulating Alpha-Klotho Protein Levels IGF1R IGF1 MTOR AK1 PMC6436826__F1 Molecular Mechanisms of Regulation of Sphingosine Kinase 1 DES LPP CERK PMC3650130__F85 Recently, Zhang et al ATM ALK PMC5515628__F1 AD immunopathology and mechanisms of action of targeted therapies IL31 IL4 OSMR PMC6721560__F4 The PI3K/Akt/mTOR signaling pathway TSC2 RICTOR TSC1 SESN3 GSK3B RHO PTEN EIF4E MTOR DEPTOR RHEB MLST8 PMC3606104__F3 Identification of genetic networks that regulate the induction of filamentous growth SWI5 CDC20 GLO1 FAR1 MCM2 CDC27 ORC3 PMC7909315__F4 F-actin correlation pathway diagram DNAJA4 ROCK1 RHO RAC1 PMC4382258__F2 Essential role for autophagy in life span extension TSC2 ULK1 TSC1 TFEB PMC8093429__F1 Cellular Responses to the Efferocytosis of Apoptotic Cells RAB17 DKFZp686F0183 PMC8200538__F3 Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype PLCG1 GCLC CNOT8 DPP4 CCR4 HERC3 CCL5 REPIN1 TMED1 ZNF335 NR2F2 MAF ITK LCP2 TBX21 ARG2 IL33 IL1RL1 CCL17 JUNB CXCL12 CCL22 GATA3 CCL3 PMC3542205__F5 Illustration of the expression levels of enzymes within the glycolytic pathway and major connections in the C PDC PGM3 PGM2 HEL-S-68p HEL-S-162eP PMC5499884__F10 Molecular indices of viral disease development in wild migrating salmon EGF HERC6 TLR9 MAPK8 EGFR MAPK14 EIF2AK2 CCL2 MTOR USP18 MX1 IFNG TLR7 XAF1 TLR4 F2 IL17A SRC IL2 IL4 PSMB9 IRF-1 PSMB8 CD68 PLAUR STAT2 IRF7 FOS IRF9 FGF2 VEGFA TLR3 RNF125 MAP2K1 ERBB2 IL27 IFIH1 TGFB1 MAVS PMC11278853__F2 Emerging evidence regarding the anti-cancer features of novel lipid-lowering treatments, including CETP inhibitors, bempedoic acid, and PCSK9 inhibitors PCSK9 CCND1 ACLY AXIN2 BAX PMC11278853__F1 Schematic illustration depicting the potential anti-inflammatory effects of hypolipidemic agents primarily targeting LDL-C reduction NLRP3 PCSK9 VCAM1 VEGFA ACLY HMGCR PMC10472888__F3 GPX4 in cell death, autophagy, and disease GPX4 GCLC SLC7A11 HEL-S-64p PMC8201009__F1 Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy CAS1 FUT1 GAL hCG_1998026 PMC5415836__F2 Following TLR2-ligand interaction a signaling pathway is started using MYD88 as an adaptor molecule IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 PMC5703693__F3 Molecular mechanisms of the attenuation of PI3K and Akt, and the dysregulation of PI3K/Akt signaling pathway by gingipains SP110 BAD MTOR PMC11683146__F6 Tyr-Pro-induced Aß signaling pathway in SAMP8 mice BACE1 APP PMC8262334__F2 Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming SALL4 ENO1 PKD1 HIF1A PMC8945445__F2 Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols IL18 TRAF6 MYD88 IRS1 PMC7915224__F5 RAS regulation by posttranslational modifications RIN1 SMURF2 GSK3B SRC HRAS PMC3124472__F4 Proteomic Analysis of Pathways Involved in Estrogen-Induced Growth and Apoptosis of Breast Cancer Cells TLE3 BAD RUNX3 RAP1A SRC FZD7 TYK2 RAP1GAP CDC2 CALM1 PMC4659505__F12 Complexity of the direct and indirect effects of mTOR on signaling pathways TSC2 RICTOR TSC1 MTOR DEPTOR MLST8 PMC11557563__F2 Glycolysis and its ancillary pathways in WB muscle HEL-S-133P PHGDH HEL-S-281 PMC4581244__F1 Alterations of the KP in EAE and MS KMO IFNG PMC2603471__F1 Ageing, oxidative stress and cancer: paradigms in parallax ABCC3 AREG MMP9 LCN2 PTGES TNF PTHLH IGFBP5 TAGLN CXCL13 PLN TNC CXCR4 TNFSF10 BCL2 GAL TGFB1 PEG3 LAMC2 PMC2495063__F3 Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes TSC2 PTEN HIF1A MTOR PMC5124559__F7 Schematic representation of the peptide generation pathway EP300 CUBN HNF1A CPN1 BRCA1 CFI PMC7216262__F3 mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases CNTF EGF IGF1 PTEN MTOR PMC3807004__F2 Mitochondrial biogenesis by HLA20 involves activation of the Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha (PGC-1A) pathway POC1A TFAM PMC4716629__F1 NFKB/p65 ubiquitination and degradation signaling ING4 PDLIM2 RHD COMMD1 PMC4727420__F2 Global view of biological processes and molecular functions of HDL proteins HEL-S-62p SAA4 APOA4 IHH C4B_2 APC APOC2 APOC1 PON1 APOD SAA1 GPLD1 SELL APOM LY6E PLTP VTN AHSG APOC4 RBP4 B2M APOA2 APOE PMC3970295__F4 Wnt signaling as a pathway to increase bone formation APC SOST LRP5 LRP6 FRAT1 PMC3527976__F2 Two rapamycin-sensitive myogenic mTOR signaling pathways MTOR IRS1 PMC6970510__F2 Different regulation of PAQR3 on multiple signaling pathways.Notes: Reproduced from Zhao Z, Chen Y BTRC PAQR3 TWIST1 DDB2 ATG14 PMC8222785__F1 Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas HEL-S-26 EGFR PNN PTEN MTOR PMC2888472__F2 Simplified scheme of signaling pathways required for maintenance of pluripotency of mESC (top panel) and hESC (bottom panel) SMAD2 LIF SMAD1 DKFZp781O1323 STAT3 PMC7406421__F2 Mechanism of human CoVID-19 infection: 1: infected animals can infect Humans followed by human-to-human transmission through aerial droplets and contact CRP IL33 IL6 CCL2 ACE2 PMC4981676__F1 Overall organization of JNK signaling pathways RAC1 RIPK2 MAP3K7IP1 CDC42 PMC9092395__AF1 LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway DDX54 MTOR PMC8529555__F6 Network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease HSD17B12 HDAC3 ACACA EBP SC5D DHCR24 NPC1L1 GCK CREB1 IDI1 ACSS2 TM7SF2 WT1 CYP7A1 CYP51A1 GPAM NR1i1 SCD FDPS ATF4 LDLR PKLR NFYC SREBF2 KLF13 FASN ME1 SQLE PNPLA3 ALDOB AACS KLF5 MVK ELOVL6 DDIT3 HMGCR ACAT2 TM6SF2 HNF4A MVD FADS2 DHCR7 FDFT1 FADS1 YY1 ACLY MSMO1 PMC5711019__F9 Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling ZHX3 KCNN3 INA ENPEP ZFHX3 PITX2 PMC3515033__F5 Cytokine intracellular signaling pathways STAT1 TRADD IL1R1 MYD88 TRAF2 IL1B FADD IFNG PMC3515033__F4 Neural and humoral activation of the brain by the periphery NTS CP PMC3515033__F3 Classification of nucleotide-binding oligomerization domain proteins (Nods) NOD1 TNF IL1B NOD2 PMC4648866__F1 Glycerol biosynthesis in respond to osmotic stress and redox statue and the interrelationship with yeast-derived aroma compounds in S HEL-S-49 GPD2 GPD1 PMC3515033__F2 Classification of Toll-like receptors (TLRs) TLR8 TLR5 TLR7 TLR4 TLR9 MYD88 TLR1 TNF TLR3 IFNG MAL PMC12004807__F6 Distribution of genes in the TNF signaling pathway IL15 CYLD CXCL10 LIF FADD MLKL ITCH PMC10814963__F4 Proposed model for Fyn-CD133 signaling to the PI3K pathway induces melanoma intrinsic and acquired resistance to anti-cancer agent in melanoma cells FYN BRAF MDM2 GRB2 PTEN GRB7 PMC10814963__F2 Common mechanisms of melanoma progression and treatment resistance BRAF EGFR NRAS PMC11519383__F7 Schematic summary of the study RUNX1 THBS1 TGFB1 PMC8870128__F2 Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis GPR31 PMC3432767__F1 Rac and RhoA signaling pathways during cytokinesis VAV3 PAK1 ARHGEF7 ECT2 ARHA RHO RAC1 PMC8638120__F3 Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases CLTB CLTA ATP6V0A2 AP2A2 DNM3 STX18 ATP6V1G1 STX2 CLTC NAPA CACNA1A PMC5852601__F1 Relationship between epithelial-to-mesenchymal transition (EMT) and the Wnt pathway in glioblastoma-derived stem cells (GSCs) APC GSK3B LRP5 LRP6 ROR1 FZD5 PMC11731108__F2 T cell senescence‐related signaling pathways STAT1 CGAS ATM LCK ZAP70 TNF MAP3K7IP1 TERT STAT3 PMC8150330__F1 Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics AAK1 NRP1 FURIN ACE2 TMPRSS2 PMC3894710__F2 Autophagy: A Crucial Moderator of Redox Balance, Inflammation, and Apoptosis in Lung Disease ULK1 MTOR ATG14 PMC7794713__F2 Net cholesterol flow through the body LDLR ABCA1 ABCC2 HMGCR ACAT2 PMC1768457__F1 CD14/toll-like receptor 4 (TLR4) intracellular signalling complex CD14 TLR4 LBP TRAF6 MYD88 PMC7982659__F3 Ingenuity Pathway Analysis (IPA) EREG CEBPE MAP2K1 CSF3 AREG MAP2K5 HBEGF CEBPA TRIM24 CSF1 TGFB1 PMC9297058__F1 Brain Abnormalities in PIK3CA-Related Overgrowth Spectrum: Physician, Patient, and Caregiver Experiences PTEN RAC1 MTOR CDC42 PMC1636619__F8 Oncogene cooperation in malignant rasV12, scrib−/− tumors FOS SCRIB PMC12240100__F6 Hippo-YAP signaling pathwayOverview of the Hippo-YAP signaling pathway, including the interactions between MST1/2, LATS1/2, YAP/TAZ, and TEAD LATS1 MOB1A MOBKL1A LATS2 PMC12240100__F5 PI3K/Akt signaling pathwayThe PI3K/Akt signaling pathway regulates cell growth, survival, metabolism, and angiogenesis TSC2 TSC1 EGFR MDM2 RHEB PMC12240100__F3 Hedgehog (Hh) signaling pathwayThe Hedgehog (Hh) signaling pathway regulates embryogenesis, cell proliferation, and tissue repair KIF7 SUFU GLI3 GSK3B SHH SMO DYRK1B PMC12240100__F2 Canonical Wnt/Beta-catenin signaling pathwayCanonical Wnt/Beta-catenin signaling pathway: the Wnt/Beta-catenin pathway regulates cell proliferation, differentiation, and survival EGF TCF3 APC LRP5 CD44 CCND1 LRP6 PMC4287430__F1 Predicted model of the S CS OMP FH DCT OGDH LPA RPE LAT PSD PYGL PMC8247027__F1 Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells GRB2 HRAS MTOR PMC5998742__F1 Toll-like receptor (TLR) 4 signaling pathway TLR4 IRAK1 TRAF3 TRAF6 IRF3 IRAK4 MYD88 PMC3815682__F1 Comparison of typical mammalian cell citrate metabolism and the metabolic pathway for net citrate production CS CIT MAL PMC11932283__F6 Cerebral CYP enzymes in major exogenous substance metabolism—opioid biotransformation CYP3A4 PMC8438590__F1 Antibody dependent enhancement: Unavoidable problems in vaccine development IL10 TBK1 TANK ATG12 IRF7 IRF9 GSK3B TRAF3 IRF3 MYD88 DKFZp686F0183 TLR3 SYK STAT3 PMC11829548__F2 Toll-like receptor signaling pathways TLR5 TLR9 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 TLR4 TIRAP TAB3 PMC7286274__F3 Putative signaling effect of ⋅NO on nodule development ABI3 PMC6209660__F6 Potential mechanism of sodium butyrate on STZ-induced type 1 diabetes HMGB1 IL1B PMC11961548__F7 Construction of miRNA-gene regulatory networks in rat fatty liver associated PNF cases TAF13 EIF3S6IP TAF4 BRD4 PMC12220693__F1 Normal tryptophan synthesis pathway ASMT HEL-S-90n KYNU KMO AFMID AANAT PMC9548536__F3 Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine IL10 IL13 IL22 ARHA IL6 IL4 IL6R IL10RB STAT3 PMC3246665__F6 Diagram of signalling pathways indicating the possible mechanism by which sildenafil reverses the memory deficits in aged transgenic Tg2576 mice CDK5 ARC BDNF PMC11672511__F5 TNFR1-mediated survival and cell death pathways TBK1 RIPK1 TRADD CYLD RIPK3 TNF OPTN FADD ZBP1 MLKL PMC11672511__F4 NLRP3 inflammasome induction by mtROS NLRP3 CMPK2 TNF IRF-1 PMC8657754__F7 Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy CASP3 ATM CASP9 PARP2 THBS1 CASP8 BAX PMC3871884__F8 Schematic diagram illustrating central role for ROS and Src in hypoxia-induced pY654-Beta-catenin/HIF1A formation and tumor EMT EGFR SRC HIF1A TGFB1 PMC11361850__F3 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulate the immune response NLRP3 TLR4 IRAK1 ERN1 TRAF6 PTEN MYD88 PMC9324584__F2 Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma PDGFD VEGFC THBS2 VEGFA IL6 THBS1 PMC11361850__F6 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) promotes axonal growth and neuronal regeneration HMGA2 NLRP3 NGF SMAD2 CBL PMC11361850__F5 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulates apoptosis and autophagy MAPK10 FGF2 TRAF6 PTEN MTOR HDAC5 BAX BRD4 PMC11672511__F1 Activation of the cGAS–STING signaling pathway by cytosolic mtDNA TBK1 CGAS IRF3 PMC5118094__F7 Cocaine regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) NFATC1 HEL-S-15 MYC DOCK1 RHO EIF4E ARPC5 CRK ARPC4 ARPC2 HEL-68 GRB2 SRC ARPC1B CDC42 PMC2923753__F2 Signalling pathways that regulate Candida albicansCHS gene expression MID1 PMC11907960__F2 Key effector cells in radiation-induced lung injury SMAD2 ARHA MTOR PMC11015576__F8 PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer TBK1 HMGB1 CGAS IRF3 PREX2 PMC11688492__F2 The molecular mechanisms related to SARS-CoV-2 and S protein effect on vascular dysfunction and BBB disruption ACE2 IL1B ADAM17 PMC11688492__F4 The molecular mechanisms related to astrocytes activation by the SARS-CoV-2 and S protein DPP4 NRP1 MMP9 PMC9010946__F9 Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification TH KIT DES LAT PMC11688492__F3 The molecular mechanisms related to microglia activation by the SARS-CoV-2 and S protein NLRP3 IL18 TLR4 MYD88 PANX1 IL1B ADAM17 PMC8310117__F2 SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications IL16 VWF IL1B TF TMPRSS2 PMC4073990__F4 Schematic description of the signaling pathways known to be activated by CCK1R and CCK2R EGFR GRB2 SRC HBEGF RHO MTOR CRK IRS1 STAT3 PMC9354016__F2 The mucin-like glycoprotein FCGBP in mucosal immunity and cancer FCGBP IL4 TFF3 MUC2 PMC5118094__F3 Environmental enrichment regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) GNB2 AGTR1 GNB5 GNA14 GNG7 GNG10 AVPR1B HRH1 BTK GNB3 TBP GNG2 GNG11 GNG5 CSK GNG3 GNG12 GNA11 ADRA1B GNA15 AVPR1A CHRM3 GRB2 ADRA1D ADRA1A HTR2A HTR2B GNB1 GNB4 PMC1851929__F8 Proposed model for the activation of oligodendrocyte apoptosis by MHV infection BCL2 FADD BAX PMC6138873__F1 A model depicting cryptochrome signal transduction mechanisms in Arabidopsis CRY1 CRY2 RFWD2 PMC9092267__F8 De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway CSNK2B DVL3 PMC6215617__F1 WNK pathway and major cancer-associated signaling pathways SMAD2 OSR1 SGK1 PMC7714562__F3 Overall depiction of the TRAF6-mediated signaling pathways TLR9 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 CBL TLR8 TLR7 TLR4 SRC TAB3 PMC4723140__F2 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone ACACA ECHS1 FASN HEL-S-5 PMC4723140__F1 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone HEL-S-30 PKN2 MPC2 HEL-S-133P HEL-S-32 PMC12152351__F6 miR-1236-3p targets Toll-like receptor 4 to suppress the anti-Mycobacterium tuberculosis activity of macrophage IL18 TLR4 TRAF6 IL6 MYD88 TNF PMC3277127__F5 Curation of phosphoproteomic profiling and bioinformatics delineates distinct tyrosine kinase signaling pathways in an oncogene-specific manner PLCG1 ERG EGFR PTPN1 LYN PTK2B GRB2 SRC CTNND1 HEL114 EPHA2 PXN STAT3 PMC3061960__F5 NFKB activation in B cells CARD11 TLR4 BCL10 BCR IRAK1 RELA IRAK4 PMC9114699__F1 Thyroid Cancer and COVID-19: Prospects for Therapeutic Approaches and Drug Development RET BRAF MTOR PMC8744686__F4 Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy ATF4 RAC1 PMC8902753__F2 Gut Microbiota in Inflammatory Bowel Disease NLRP3 NLRX1 NLRP6 COIL NOD2 SIRT1 STAT3 FOXP3 PMC3524085__F7 Ingenuity pathway analysis of the 10-edge pattern subgraph showing cancer-associated interactions among its nodes CREBBP RELA NR3C1 RBM8 NCOA1 NCOR2 STAT3 PMC8491225__F2 Biological role of metabolic reprogramming in pancreatic cancer ME1 GOT2 GLUD1 HEL-S-32 PMC4723140__F3 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone SQLE PMVK MVD DHCR7 FDPS FDFT1 SC5D MVK IDI1 HMGCS1 HMGCR PMC8491225__F1 Biological role of metabolic reprogramming in pancreatic cancer HEL-S-133P GFPT1 HK2 PMC7749645__F1 Convergent type I interferon and proinflammatory cytokine pathways shared between SLE and COVID-19 TBK1 STAT1 TLR7 STAT2 IRF7 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 MYD88 IRF-1 PMC3442981__F1 Metabolic pathways for 2,3-butanediol biosynthesis and pyruvate metabolism in S BDH1 GPD2 GPD1 PMC5607433__F5 Cytokine-cytokine receptor interaction HGF IL9 VEGFA AMHR2 CXCL2 TPO IL6 TNF TSLP TNLG7C PRL EDAR LEP LTA KDR NPS IL23A LEPR IL6ST SP1 IL20 OSM LTBR PMC6388767__F1 Bromouridine sequencing (Bru-seq) of MI-503 treated Ewing sarcoma cells identifies the SSP as a key oncogenic target PSAT1 PSPH HEL-S-51e MTHFD2 PHGDH PMC4685484__F6 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction HMGB1 IRAK4 MYD88 TIRAP PMC5073880__F4 Diagram of pathways by which AGEs affect genes involved in steroid synthesis and follicular development CYP17A1 SMAD1 STAR DKFZp781O1323 PMC4685484__F5 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction HMGB1 TLR4 IRF3 IRAK4 MYD88 TIRAP IFNG PMC8662989__F1 Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction ALDOB MPC1 MPC2 GCK KHK PMC7805053__F4 Schematic diagram depicting IL17RD (Sef) modulation of the TIR signaling pathway TLR4 TRAF6 IRF3 MYD88 MAL PMC7547786__F2 Signaling pathways of IL-17A, pathological effect, and potential drug targets MMP3 COX2 CXCL1 CXCL5 MMP9 CXCL8 TRAF6 IL17RC PMC7049061__F1 Bibliometric analysis flow chart of mTOR pathway in liver disease research TH OGT PMC5123862__F6 Polymerase exchange during TLS on the lagging strand POLN PCNA CPD PMC7547786__F1 Th-17 cell polarization from naïve CD4+ T cells and activation APC IL17A RORA IL23R STAT3 PMC11852866__F8 ITIH5-mediated fibroblast–macrophage crosstalk exacerbates cardiac remodelling after MI CD44 ARG1 STAT3 PMC3107984__F3 Genetic analysis of biological pathway data through genomic randomization OXCT1 HMGCL BDH1 BDH2 PMC9636403__F1 Identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade CCR5 IFIT2 CCR2 HLA-G CX3CR1 IFITM2 CXCR6 IFITM1 CCR1 MX1 ITK CXCL16 CD8B CCL13 CD2 PRF1 CCL19 PDCD1LG2 CD3G IRF-1 CD3E CD3D SET PMCH FPR2 ENG CD8A C3AR1 HLA-B HLA-C CXCR3 HLA-A ZAP70 CCL23 IFIT1 PMC5295629__F4 Interactions of NIK wild-type and mutants MRPS7 HEL-S-84 TRAF3 RPL19 LAS1L SLC25A12 MCMBP SMC1A SLC25A11 RPS19 SLC25A13 GCS1 PGAM5 NCL CALU HEL-S-310 RPN1 HLA-B HLA-C HLA-A DDX50 RPL17 SEC16A DPM1 SLC25A22 NFKB2 RCN2 RHOT2 RBFOX2 GLUD1 MSI1 NOL9 CTCF AIFM1 SFXN4 MYBBP1A YME1L1 RPS6 PRKDC NOP58 PFKP RPS12 FASN SLC25A10 AKAP8 LBR CDC37 RPS9 MAGED2 SEC63 NOM1 PRPF19 EMD VEZF1 NOP56 TRIM28 RPL10 C1orf57 TRAF2 ACSL3 PMC5295629__F1 Noncanonical NFKB signaling pathway TRAF3 LTB RELB TRAF2 PMC2908766__F2 PI3K dependent signal pathway BAD GSK3B MTOR PMC5295629__F2 Interaction network of the noncanonical NFKB signaling pathway FAR1 HNRNPAB ETV6 TRAF3 TROAP HOMER1 HSPD1 SNAP29 RPL19 RANBP2 LAS1L FBXW7 SLC25A12 SLC25A11 USO1 RGPD3 ANKRD34B GOLIM4 SLC25A13 PGAM5 FNTA CALU KLHL22 HEL-S-310 TNF DIABLO HTRA2 HLA-B HLA-C SPAG5 HLA-A MCM3 RPL17 SEC16A TRAF5 RCN2 RHOT2 FYCO1 DCAF7 RAB11FIP5 GLUD1 TBK1 PTMS HEL-S-97n KTN1 SFXN4 BIRC3 USP9X RPS6 NOP58 ZC3H18 FBXO28 FKBP5 GOLGA3 CDC37 RPS9 PHGDH PRPF19 DYRK1A BIRC2 EMD NOP56 NFKB1 RELA TRIM28 RPL10 REL TRAF2 NUMA1 ACSL3 PMC7407626__F4 Summary of intrinsic apoptotic pathway PAF1 BAX PMC12075242__F3 ETBF promotes tumorigenesis by distinct mechanisms METTL14 TLR4 KAT2A NFAT5 PHF5A STAT3 PMC8227573__F1 An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain TIMP1 TIMP3 SPRED1 PTEN PMC7561614__F1 Metabolic pathway for squalene synthesis in oleaginous yeast MVD CIT IPP MAL PMC12075242__F5 Fn involved in immunotherapy CGAS IRF3 PMC7349686__F2 Possible signaling mechanisms of ectopic osteogenesis in skeletal muscles RUNX2 SMAD2 SMAD4 HDAC5 MAP3K7IP1 ID1 TGFA SMAD1 DKFZp781O1323 PMC7667972__F9 Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch GPR55 DDHD1 DAGLA COCH PMC3272823__F3 Involvement of the ERK pathway in the TGF-Beta-induced epithelial-mesenchymal transition EGR1 HGF SMAD2 GRB2 SMAD4 PMC8945730__F4 Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age ULK1 ATG12 ATG3 RP2 ATG10 DKFZp686F0183 PMC7849461__F2 Renin-angiotensin-aldosterone system ACE2 IL1B PMC8040309__F3 FGL1-involved signaling pathways PARP1 LAG3 MTOR FGL1 STAT3 PMC5410324__F1 PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases PI3 BRAF EGFR PMC7710624__F7 Genetic and Physical Interaction Mapping Reveal New Facets of RAS Pathway Biology NRAS RALA ARHA RALB HRAS RADIL PMC2745891__F6 Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mTOR activity and p27Kip1 localization TSC2 TSC1 GSK3B SHH SMO MTOR PMC2781394__F8 HGF-mediated inhibition of gluconeogenesis in primary hepatocytes USF1 HNF4A HGF PMC6695538__F1 The crosstalk between estrogen receptor and growth factor receptor intracellular signaling pathways CCND1 CDK4 MTOR PMC4065383__F2 Origins and removal of ribonucleotides in DNA FEN1 INS DNA2 PCNA PMC11201890__F2 USP5 participates in immune regulation through a variety of signaling pathways NLRP3 FOXM1 TRAF6 PMC2838378__F2 Simplified schematic of the T cell receptor signaling pathway ITK LCK GRB2 LAT PMC10380517__F2 CDK4/6 Inhibitor Resistance in Hormone Receptor-Positive Metastatic Breast Cancer: Translational Research, Clinical Trials, and Future Directions FGFR1 WEE1 CDK4 MTOR CDK6 PMC2838378__F1 Simplified schematic of the IgE receptor (FcERI) signaling pathway FYN LAT2 LYN GRB2 SYK LAT PMC8269036__F2 mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease YAP1 AMOTL2 NF2 SMAD4 TEAD2 FOXA2 PMC11946680__F7 Action induced by 3-MCPD RIPK1 RIPK3 MLKL PMC5108628__F1 Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity TBK1 ADAR IRF3 SMS FADD MAVS USP18 PMC6911338__F7 Schematic diagram of miR-155 intercellular transport and activation of mTOR signaling pathway EIF4E MTOR DEPTOR PMC5524291__F9 An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation CCND1 BCL2 IRF4 BCL6 PMC3795364__F6 Schematic presentation of the influence of angiogenesis inhibitors on EC signaling CXCR3 MAP2 PF4 MTOR PMC11568081__F5 Figure illustrates the mechanism by which kaempferol enhances sensitivity to anti-digestive system tumor drugs PTBP1 EGFR STAT3 BAX PMC8584162__F2 Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer ALK DLG2 FRS2 GRB2 SHE SRC JAK3 ETV5 IRS1 STAT3 PMC11568081__F4 Figure shows how kaempferol suppresses metastasis and invasion while inducing autophagy in digestive system tumors ATG12 EGFR SRC CDC2 MTOR DKFZp686F0183 BAX PMC11568081__F3 Figure illustrates how kaempferol inhibits digestive system tumors cell proliferation ATM PTBP1 CCNB1 CDC2 H2AX BAX PMC11568081__F2 Figure illustrates how kaempferol induces apoptosis in digestive system tumors NLRP3 BAD BIK CDC2 GPR49 JUN CYP27B1 BAX PMC9465383__F1 Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy TRIB1 LDLR MTOR USP11 FASN CD36 PMC9329679__F1 Critical Appraisal of Filgotinib in the Treatment of Ulcerative Colitis: Current Evidence and Place in Therapy STAT2 IRF9 TYK2 JAK1 PMC2424235__F1 Auxin signaling CAND1 RBX1 PMC4935211__F1 Schematic diagram of TRAIL-induced apoptotic signaling cascades FADD BAX PMC5593678__F2 Autophagy in hepatocellular carcinoma: friend or foe GAPT ATF4 EGFR EIF2A PTEN RHEB PMC5768349__F4 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics CD133 SLC7A11 SOX1 GIP CACNB4 SOX4 SIK1 RARA CGB8 ELAVL1 DCN ATOH7 NT5DC3 SOX11 CCND1 TMSB15B P2RX1 CDH2 PPIC EGR1 SNRK BSN VPREB3 KLF7 RET E2F7 WNT3A CP CACNB1 TCF4 TGFBI PLAG1 PMC5768349__F7 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics FGD4 ADAMTS12 SEMA3A EFNA1 AJUBA IL6 PDK4 RAB3IP PID1 UNK CD40 CELF2 CP PMC5618569__F2 Schematic representation of the cytoplasmic and nuclear functions of the autophagy—related factors Beclin-1, LC3B and p62 PML RNF168 MTOR PMC3794382__F1 Gene sets are not pathways CD14 SET TRAF6 ECSIT TNF MAP3K7IP1 TRAF2 PMC5618569__F1 Stages of autophagy PML ULK1 ATG16L1 ULK2 PMC2783241__F2 Kidney development: from ureteric bud formation to branching morphogenesis EGF RET GREM1 HGF GDNF SPRY1 GATA3 BMP4 PMC6335102__F8 ANG II induces cardiac hypertrophy by multiple means involving direct actions on cardiac myocytes (cm) or the release of paracrine factors from other cell types, such as endothelial cells and fibroblasts/myofibroblasts TRPC4 NAMPT SIRPA TRPC1 EGFR SRC NOX4 ARHA MTOR ATR ADAM17 PMC6335102__F7 ANG II signaling and vascular fibrosis SMAD2 EGFR HBEGF ARG1 ADAM17 PMC9464936__F3 Know when to fold ‘em: Polycomb complexes in oncogenic 3D genome regulation BCOR PRC1 BCORL1 KIP75 BAP1 PMC7439504__F6 Beyond the cell factory: Homeostatic regulation of and by the UPRER BCL2 TRAF2 FOXO1 PMC9284233__F2 Glycolysis in Innate Immune Cells Contributes to Autoimmunity TBK1 CSF1R CCR7 CD40 CD80 ARG1 IRF4 HEL-S-133P HK2 STAT3 HEL-S-162eP PMC8847744__F5 Intestinal Infection of Candida albicans: Preventing the Formation of Biofilm by C. albicans and Protecting the Intestinal Epithelial Barrier STAT1 BAD SOCS3 STAT3 BAX PMC5193387__F4 Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example MUC1 GNE OGT GC EGFR NPL RENBP COCH PMC6861177__F1 Mitochondrial quality control NRF1 TFAM OPA1 PMC10390316__F1 Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases ACVR1 CXCL10 EGFR ARHA IL6 CCL2 PMC12125403__F4 Posttranslational modification of NLRP3 inflammasome components via ubiquitination and deubiquitination RNF31 OTUD6A HUWE1 BRCC3 TRIM62 USP30 TRIM59 STAMBP TRIM65 TET2 TRIM40 NLRP3 SLC25A3 INSIG1 METTL3 ZNF883 USP14 TRIM50 USP9X USP47 TRIM24 TNFAIP3 SKP2 PMC12125403__F1 Transcriptional regulation of NLRP3 expression NLRP3 FYN ELF3 AHR NFAT5 MAPK14 TNF MTOR FADD CD36 PMC4528364__F8 Conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy ATG3 DCP2 ATG10 ATG14 PMC5925455__F7 Hypothetical model for the aggravation of autoimmune response in Pdmx-associated and spontaneous NT1.The immune response in NT1 is highly heterogenic with different pathways affected during the disease progression P2RY11 CTSH TNF IFNG PMC8424797__F2 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy RELA UHRF1 AKT3 TET1 BAX PMC8424797__F1 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy IRF9 FOXO1 PMC8424797__F3 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy CMTM6 TERT CMTM4 PMC3405855__F5 Models of apoptosis-induced proliferation in mammals EGR1 FOS FADD CP PMC7543933__F2 IFN-Alpha-driven pDC-B cells crosstalk leading to antibody production in response to viral infection PDC TLR7 IFNA4 IRAK1 CD40 IRAK4 MYD88 IL1B PMC6279409__F2 Sensing danger through a “finger” CNBP MYD88 PMC9697017__F6 Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging ELF2 HEL-S-30 DAO GPT SVIP MCU CIT POR GCG NR1C1 SELL PLN PI3 F2 SKA1 HRC CRTC2 COIL MAL PMC7404278__F1 Molecular switches regulating hair growth SHH SMO PMC6921965__F1 DSB repair pathways in mammalian cells FEN1 POLE RAD52 RAD51 BRCA1 PMC2500163__F4 HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study APOB VLDLR RPL7 RPS3A PMC8780133__F3 N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy GSK3B TRPC6 BDNF CRTC1 PMC8429596__F1 Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma CXCL1 FAP MSC MIA STRC PMC9440251__F6 Nintedanib induces a senolytic effect in senescent HDFs via JAK2/STAT3 pathway CDK2 STAT3 PMC4045488__F1 MicroRNAs in pancreatic cancer metabolism FAT1 CD36 PMC8615627__F2 LncRNAs: Novel Biomarkers for Pancreatic Cancer EGF FOXO3A OTUD7B EGFR PTEN FOXD1 RHEB TSC2 TSC1 GRB2 RAF1 JAK1 STAT3 PMC8615627__F1 LncRNAs: Novel Biomarkers for Pancreatic Cancer LIMK1 NODAL RUNX2 SMAD2 SMAD4 TRAF6 RHO SMAD1 TF DKFZp781O1323 PMC8187363__F3 Involvement of accessory proteins in diseases FHL1 BCR GAB2 LCK ZAP70 GRB2 IQGAP1 SRC SHOC2 PMC8187363__F2 Involvement of RTK-RAS-MAPK accessory proteins in signal transduction FHL1 NPM1 FRK ZAP70 GRB2 IQGAP1 SPRED1 SHOC2 ERBIN LPA CBL PMC8102505__F1 Autophagy pathway ULK1 ATG12 ATG3 SQSTM1 AMBRA1 TRAF6 WIPI2 UVRAG STX17 ATG10 ATG14 SNAP29 PMC9582647__F1 Plasma membrane and brain dysfunction of the old: Do we age from our membranes? TLR4 SOCS3 GSK3B IL1R1 MTOR IRS1 IL1B PMC4377510__F5 Possible transforming pathway IGF2BP1 FAF1 PMC4801113__F2 Iron homeostasis in host defence and inflammation BMP6 BMPR2 HAMP SMAD4 TMPRSS6 HFE JAK1 TFR2 STAT3 PMC2962793__F1 a, b Bioactive eicosanoids derived from the arachidonic acid cascade COX2 COX1 PMC4404183__F2 Natural history of Beta-cell adaptation and failure in type 2 diabetes TPH1 IGF1R HGF FOXM1 TPH2 TCF7L2 PTEN EIF4E IRS1 FOXO1 PRL RHEB BCL6 TSC2 FOXD3 TSC1 IGF1 HNF4A PRLR PMC7222158__F3 Gene network of regulation of synaptic transmission, glutamatergic (obtained using Pathway Studio v PTGS2 SCN9A GRIK2 PMC1297571__F6 Simplified diagram of the proposed signalling events leading to Cyp7b gene transcription in synovial fibroblasts TRADD TNF TRAF2 FADD PMC2962793__F2 Cytochrome P450 epoxygenase expression in tumor cell compartments and their potential role in cell–cell communication in the tumor stroma CYP2J2 CYP2C9 FGF2 PMC3619152__F10 Proposed pathway showing increased Nox4 expression and H2O2 levels in PPHN PA, leading to a decreased ecSOD activity and vasoconstriction, and increased NFKB and cyclin D1 leading to pulmonary vascular remodeling TH CCND1 NOX4 PMC7824059__F4 Top-ranked and interested pathways in Holstein and Jersey cows TRADD FOS PTGS2 TRAF6 CXCL3 CXCL2 TNF MAP3K7IP1 PPIF EDN1 TNC NFKBIA CAV3 CAV2 P2RX1 IL1B TAB3 PMC8228851__F1 Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases SOCS3 IL11RA MTOR PMC3734218__F1 Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis GGH VIT SHMT1 MTHFD1 FPGS HEL-S-22 MTR SLCO1B1 MTRR DHFR TYMS TPMT ABCB1 SLC19A1 PMC5584184__F3 Postendocytic sorting of receptors along the endolysosomal pathway RAB35 PI3 EEA1 APPL1 PMC4002842__F2 Network analysis of expression profiles of 10 μmol/L AA in HK-2 cells GPX4 EBI3 ETV6 ALB TPM3 TFRC OPTN CD74 UCP2 TNFRSF9 PLAT MTF1 AMH PRF1 LEPR PCK2 SP1 CD68 F11R NAIP TCF3 IRF7 LCN2 LTB CXCL2 HAS3 PROCR SERPINE2 IRS1 MPG HEL-S-69p HEL-S-68p LTA SPIB CCL20 JAK3 KLF2 SAA2 LTBR PMC4424395__F6 Signaling pathways associated with litter size in boars NDUFAF4 MAPK3 MAPK14 INS HSPD1 MDH2 C3orf60 HEL-S-162eP HEL-S-49 CELF1 EQTN LYZL4 IL2 GSTM3 IL4 RAB2A MYLK TF PMC7653868__F2 Yellow nodes represent genes enriched in Infiltrating Ductal carcinoma of breast identified by Pathway enrichment SRI IGF2BP1 PCLAF RNF11 HDAC3 S100A10 PBRM1 ALK ARHGEF12 PFKFB4 SLIT3 RGS17 INPP4B CCDC6 PPP1R9B STRN AFF4 NGFR EML4 SDHD BAP1 RHOBTB1 HEL70 AKAP12 ARHA NMT1 GAST WWTR1 DAPK2 THBS2 CDC6 PLXNA3 SIAH2 ACLY BCL9 STAT3 PMC7653868__F1 Reactome FI network PCLAF IGF2BP1 RNF11 PBRM1 HDAC3 ALK ETV4 PFKFB4 EIF2AK2 STRN FYN MAP4 SP1 SDHD BIRC6 BAP1 HEL70 AKAP12 NLRC4 ANKHD1 Nbla10317 HRAS GAST BRCA1 TIAM1 THBS2 CDC6 ACLY SIAH2 FHL1 PLCG1 S100A10 ARHGEF12 LATS1 SLIT3 RGS17 LIMD1 RARA UBC EML4 NGFR NCOA1 DDX5 JUN RHOBTB1 MLF1 YBX1 NR3C2 ARHA NMT1 DAPK2 EP300 SETD2 SHC1 PMC8988011__F7 Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions ANKRD1 LATS1 LATS2 PMC5632348__F6 Schematic illustration of the TLR4 signaling pathway (a) and inhibition via TAK-242 (b) TLR4 IRF3 MYD88 TIRAP PMC7653868__F3 Pathway in FI sub-network HEL70 HDAC3 NLRC4 ARHGEF12 ETV4 EIF2AK2 ARHA LATS1 WWTR1 BRCA1 LIMD1 RARA NGFR NCOA1 SIAH2 SETD2 SHC1 STAT3 BAP1 PMC7293352__F3 Inositol phosphate and phosphatidylinositol signaling pathways in metazoans INPP1 IMPA2 PI3 INS IPMK PTEN PMC3596735__F5 Mechanism of response to anti-EGFR inhibitors BRAF EGFR PMC3596735__F3 ERK/MEK pathway BAD PRKCZ MOS FCGR2A ERBB3 DOCK1 EIF4E CRK GRB7 RHEB FYN LCK GRB2 CDC42 PMC8359944__F1 Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat ANGPT2 EPO VEGFA HEL-S-87p CAD HEL-S-133P PMC4076992__F2 Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease ATF4 EIF2A TRAF2 XBP1 PMC12056223__F7 Schematic summary of the role of targeting Dnmt3a mediated ID2 promoter in MMT GIG8 SMAD2 PMC10636769__F2 IORT regulates the proliferation of microRNA-223, thereby reducing EGF levels and ultimately attenuating the EGFR signaling pathway EGF EGFR MTOR PMC4474537__F4 BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency PIK3R1 EPOR EFNA1 SMAD2 SMAD4 CRKL DLG4 PRKCA TAF11 FYN MAPK12 KDR BCR STK35 CCT7 SRC PSEN2 CSK SETDB1 CDKN1B ERH BARD1 YWHAQ IGSF21 MCM2 CXCR4 KPNA2 HEL113 PSMD2 MYOD1 CDC42 BAD NCK2 PTN EEF1G UBE2I NCOA1 YWHAG MAFG TAF1 GRINA CDC37 ARHA PS1TP5BP1 HEL-S-102 PTPRC PRMT1 RAN SHC1 PXN PMC6947309__F1 Stimulation of a particular TLR by DAMPs and activation of the IL-1 pathway via stimulation of IL-1R TRAF6 IRAK4 MYD88 PMC5668000__F6 Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer MAX MYC PRKD1 PMC7800773__F1 Combination therapies for MPNSTs targeting RABL6A-RB1 signaling CDK2 CDK4 RB1 CDK6 PMC8954347__F1 LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection CARD9 TLR4 TLR9 BCL10 IRAK1 TRAF6 SYK IRF3 IRAK4 MYD88 IL1B PMC3734242__F8 Role of PTPA in the Destruction of Periodontal Connective Tissues TRADD SRC TRAF6 MYD88 PTPA TRAF2 IL1B PMC8630816__F3 MCP-1 targeting: Shutting off an engine for tumor development TNLG1B GSK3B IL33 SRC TNF MTOR STAT3 PMC3742868__F11 Proposed scheme for the role of mTOR in p53-induced kidney cell injury PMC5417715__F2 Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut EGFR CDK9 MEA1 STAT3 PMC4324555__F5 CREB and the CRTC co-activators: sensors for hormonal and metabolic signals SIK2 CRTC2 TAF4 PMC5733538__F6 The positive feedback regulation between transglutaminase 2 (TGM2) and TLR4 signaling in hepatic stellate cells (HSCs) activation and liver fibrosis CD14 TLR4 IFNA1 IRAK1 CXCL10 IRF3 CCL5 IL6 MYD88 IL1B PMC5400276__F3 Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC8861086__F3 Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease IL36A IL33 PTEN MYD88 MTOR PMC8438545__F2 Evaluation of the molecular response of corpora lutea to manganese–amino acid complex supplementation in gilts SQLE PMVK MVD DHCR7 FDPS EBP DHCR24 MVK HSD17B7 TM7SF2 HMGCR ACAT2 PMC8977492__F2 Adenosine-A2A Receptor Pathway in Cancer Immunotherapy IL10 ADA HIF1A PMC1397816__F2 Activation of canonical Wnt signalling pathway in the presence of Wnt signals APC LRP5 LRP6 PMC1397816__F1 Inhibition of canonical Wnt signalling pathway in the absence of Wnt signals APC LRP5 LRP6 PMC11686125__F5 Related target action relationship between QJ and the HIF-1 signaling pathway TLR4 EPO VHL ENO1 PFKL HEL-S-87p MTOR RBX1 HEL-S-133P TF STAT3 HEL-S-162eP PMC1397816__F5 Inhibition of Wnt signalling by a Fz-dependent pathway NLK LRP5 LRP6 PMC6737011__F9 Metabolism in WSSV-infected hemocytes showing the aerobic glycolysis, glutamine metabolism and lipogenesis pathways at the WSSV genome replication stage (12 hpi) HEL-S-26 CS CIT MAL GLS PMC4358823__F2 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies CD80 PMC4358823__F1 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies CD58 CD2 CD80 PMC4768650__F4 Interleukin-5 plays a fundamental role in the proliferation, maturation in the bone marrow, recruitment and activation at sites of allergic inflammation of eosinophils IL5RA EPX MBP LYN PMC9697478__F13 Immunomodulatory Effects of an Aqueous Extract of Black Radish on Mouse Macrophages via the TLR2/4-Mediated Signaling Pathway IL16 TLR4 STAT3 PMC4768650__F3 Eosinophils modulate the functions of a multitude of cells of the innate and adaptive immune system NGF EPX MBP CCL17 ELL PMC4768650__F2 Eosinophils contain and/or release a wide array of preformed and de novo synthesized mediators important for their effector functions CXCL1 CXCL5 MBP VEGFA CXCL8 CCL2 IFNG IL16 EPX CCL17 CXCL9 CCL23 VEGFB IL1B TF CXCL11 CCL3 PMC3667593__F5 Abbreviated Pluripotent Cell Cycle HINFP CDK2 ATF1 YY1 CDK4 CDC2 SP1 IRF2 CDK6 PMC9235300__F2 Telocytes in Fibrosis Diseases: From Current Findings to Future Clinical Perspectives RSPO3 HGF RUNX2 SMAD2 APC TGFBR1 SMAD4 GPR49 MTOR CERK CDIP1 BAX PMC7140616__F2 Activation of the canonical Wnt pathway in head and neck cancers is mediated by various factors EGF CIP2A DPAGT1 EGFR GSK3B CCND1 PMC7222158__F2 Gene network of positive regulation of fat cell differentiation (obtained using Pathway Studio v PTGS2 RARRES2 INHBA PMC7140616__F1 Fates of Beta-catenin, when the canonical Wnt pathway is not activated APC GSK3B WIF1 FAT1 PMC3404043__F3 Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes INS SMAD4 CIT POR EN2 DBF4 MON2 CDK7 HEL-S-69p PI3 SMC3 CDK2 MDM2 RAD21 LAT PCNA SKP2 PMC7072240__F6 Cooperative regulation of genes involved in glutathione (GSH) and NADPH synthesis by Nrf2 and ATF4 CTH GCLM GCLC MTHFD1 MTHFD2 PHGDH PSAT1 ATF4 ASNS HEL-S-64p HEL-75 PSPH HEL-S-51e PMC7523021__F2 Integration of networks of SFH targets EGF BAD F2R CHRNA7 PPP3CA EGFR GSK3B KDR MDM2 CHRM2 NOS2 JUN ICOS ADRB2 ATP2A1 TNF IRS1 PLN HEL-S-102 ADRA1B CHRM3 CHRM1 ZAP70 GRB2 BCL2 SPHK1 HTR2A TRAF2 LAT PMC10505605__F1 Extranodal lymphoma: pathogenesis, diagnosis and treatment BTK CARD11 BCR IRAK1 MYC BCL2 IRAK4 PTEN MYD88 MTOR CD79B CD79A PMC5928506__F8 MSC PGE2 secretion reprograms M1 via two independent pathways to M2 macrophages COX2 GSK3A PMC3272847__F2 E6-mediated survival signaling EGFR MDM2 MTOR PMC7862665__F2 E3 ubiquitin ligases in the development and progression of glioblastoma TRIM11 EGFR TRIM21 GSK3B TRAF6 PTEN CBL NF1 FYN TRIM9 GRB2 CIC KBTBD7 TRIM24 PFKP PHLPP1 STAT3 PMC4294344__F1 Bioinformatics analysis of the serine and glycine pathway in cancer cells HEL-S-30 SHMT1 GLS2 PSPH GLDC PHGDH PMC7734287__F8 Mechanism for Forkhead box Q1 (FOXQ1) induced angiogenesis and macrophage infiltration in colorectal cancer (CRC) tumorigenesis ANGPT2 ANGPT1 EGF PLAUR ANGPTL4 TWIST1 FOXQ1 TEC HBEGF CCL2 PMC4065761__F1 Current models of the signaling pathway of the spindle assembly checkpoint (SAC) MCC CDC20 APC PMC9608318__F2 Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19 ISG15 RSAD2 IFNAR2 IFNAR1 IFIT1 PMC3717945__F3 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance NF1 TSC2 ULK1 TSC1 GSK3B GRB2 SHE PTEN MTOR DEPTOR IRS1 RHEB PMC4749963__F2 A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells SRM SAT2 SMS PMC4838361__F5 PARI regulates the repair of single-strand gaps left behind the replication fork FBXO18 HLTF FANCM PMC5249001__F3 Pathway Studio guided network that describes regulatory connections between the deregulation of Aurora kinases, caspase-3 and osteopontin-encoding SPP1 CASP3 POU4F1 IRX2 opn VEGFA INS AURKA AURKB PMC10040566__F2 Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target VEGFC MMP19 TRAF6 IL17RC PMC7930745__F3 TMEM16A regulates cancer cell proliferation SMAD2 SMAD4 ARHA CDH2 PMC5559791__F4 This adipogenic gene network is centered on the up-regulated transcription factor CEBPA and interactions with several other transcription regulators (a) E2F4 DGAT2 FACL4 ALB HSD11B1 MYH10 HEL-S-104 COL1A1 FBXW7 GBP1 LPL COL1A2 ACSL1 KPNA3 KLF13 ACSF2 FASN LIMK1 OSTN KLF5 CEBPA DEPTOR ID3 HLA-B MRTO4 KPNA2 BCL2 KLF2 MED27 ASS1 CD36 PMC5559791__F3 Interactions of two transcription factors (PPARG and PPARD) and their direct target genes that control lipid metabolism in abdominal fat of juvenile HG and LG chickens PCK1 DGAT2 MGLL ATP6V0D1 SLC22A3 HEL-S-104 RPSA MYOM2 SLC2A3 LPL PID1 ACSL1 THBS1 FASN ANGPTL3 TCEA3 PLG AEBP1 TUBB CEBPA PDK4 OXR1 MRTO4 VLDLR MGST1 THBS2 SLC27A1 NR1C2 BCL2 HEL113 SNX4 PPARG pcap PMC7606919__F1 Resistance to immunotherapy ADAR IDO1 BTLA TIGIT LAG3 B2M TGFA POLI PMC1838573__F1 Mitochondrial pathway through Bcl-2 family members BAD IL16 TRADD TRAF1 TNF TRAF2 FADD BAX PMC6106745__F2 Viral carcinogenesis pathway and differentially expressed genes in primary NSCLC tumors CCR5 CCR3 CCR4 ARHA CCR8 ACTN4 CDC42 PMC5559791__F6 Ingenuity Pathway Analysis of RNA-Seq data showed that the canonical coagulation system was over-represented by up-regulated genes in abdominal fat of LG cockerels KL TFPI PMC9162453__F1 Heme biosynthetic pathway MLIP FECH UROD UROS HMBS ABCB10 CPO MAL PMC6409413__F7 miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGFB Signaling NEDD9 SMAD2 TGFBR1 VEGFA SMAD4 TBR1 THBS1 ADAM19 PMC7898953__F1 Extra-cellular and intra-cellular signalling regulating cardiomyocyte proliferation and cardiac regeneration CDK2 LIF CDK4 NRG1 LATS1 CDC2 LATS2 PMC9027139__F1 O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications NAGK OGT GALK2 PMC6072467__F4 Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides SI ND2 PMC2675552__F3 Mechanism of action of toll-like receptors (TLRs) TLR4 IRF3 TLR1 PMC9533025__F4 Estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes FGF21 IGF1 GDF15 IGFBP2 IL6 NRG4 BMP8B PMC5798243__F1 Physiological events post-BCG exposure: UC cell exposure to BCG results in A5B1 receptor mediated BCG internalization involving A5B1cross linking CXCL1 CXCL5 CXCL3 PMC11174684__F5 Schematic representation of the hypothetical signaling pathway activated under PEG-6000 treatment in Saragolla and Svevo cultivars MYB MAPK6 ERF TF PMC12232514__F3 Non‐caloric artificial sweeteners on gut health TLR5 MPO MYD88 PMC5821620__F1 Bidirectional E-cadherin/catenin–EGFR cross talk in epithelial biology SRC MTOR PMC11063508__F1 Schematic diagram of the entire study CASP3 DKFZp781B1423 CDK2 CCNB1 MDM2 CDK4 PTEN ATR CDKN2A GTSE1 CYCS CCNE2 PMC10034053__F2 Immune cells and immune cell-targeted therapy in chronic pancreatitis IL17A IRF3 MX1 PMC4539082__F2 Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway SMAD2 SMAD4 PMC7290813__F7 Graphical representation of selected intracellular effects and induction of apoptosis in mammalian cells following internalization of Shiga toxin holotoxins (Stx) NLRP3 IL16 CAD PAF1 BAX PMC6515079__F9 Network analysis of proteome datasets in M1 polarized (vs HES6 HEL-S-87p RPSA PS1TP5BP1 CD59 CNR2 KHSRP HNRNPC MSH3 DDX5 YWHAG HEL-S-72p KRT10 CP ACTG1 PMC8017486__F1 The design and application of AE@NPs for enhanced PC treatment EGF EGFR STAT3 PMC11257078__F1 Species differences in bile acid synthesis CYP27A1 CYP8B1 CYP7A1 PMC7290813__F8 Graphical representation of effects in mammalian cells following binding of Shiga toxin (Stx) B subunits to cell surface receptors NLRP3 BCR LYN VWF PAF1 PMC7303777__F2 Insulin signaling pathway TSC2 BAD TSC1 PDK2 GRB2 INS EIF4E MTOR FOXO1 RHEB SDHA INSR PMC11257078__F4 Bile acid crosstalk with sulfur amino acid metabolism CDO1 pcap CYP7A1 PMC11257078__F3 Bile acid regulation of the autophagy-lysosome axis TFEB LIPA FGF19 MTOR DKFZp686F0183 PMC5854681__F1 Differential control of distinct stages in adult SVZ-OB neurogenesis by different cell cycle regulatory proteins E2F4 SOX2 HDAC3 HEY2 BMP2 CDK2 CDK5 BMI1 PTEN CDC2 CDK6 PMC5517153__F1 Pathway for thiopurine metabolism RAC1 TPMT PMC7898953__F5 Effect of miRNAs on the Hippo pathway and the actin cytoskeleton CFL2 LATS1 LATS2 TAOK1 FAT4 MICAL3 TMSB4X PFN2 TWF1 AMOTL1 CSRP3 CDH2 STK38L PMC8666369__F8 IPA on CCl4-induced liver fibrosis IL16 SMAD2 PMC6596190__F1 APP can be cleaved through amyloidogenic or non-amyloidogenic pathways PIG59 APP PMC10778465__F1 The antitumor effect of SST receptors after ligand binding SST SSTR3 SRC SSTR4 SSTR2 SSTR5 BAX PMC5069779__F5 MIIP competing with Rac1-GTP to bind the PAK1-binding domain PAK1 MIIP RAC1 PMC6645632__F5 The hexosamine biosynthetic pathway (HBP) in the heart OGA OGT PMC6909129__F1 Pattern Recognition ReceptorsThe anti-adenoviral immune response is triggered by recognition of pathogen-associated molecular patterns (PAMPs) by PRRs CGAS IL18 TLR4 TLR9 IRF7 TRAF6 IRF3 MYD88 NOD2 PMC7930745__F2 TMEM16A regulates EMT and cancer cell migration and metastasis EGFR GRB2 STAT3 PMC3887939__F1 Signaling mechanisms proposed for the mammalian autophagy pathway ATG16L1 UVRAG ATG10 VAMP8 DKFZp686F0183 PMC3588000__F1 Biosynthesis of Phosphatidylethanolamine (PE) PC PCYT2 PSD PEMT PMC4278340__F1 Menin-mediated regulation of miRNA biogenesis uncovers the IRS2 pathway as a target for regulating pancreatic beta cells DGCR8 DROSHA PMC9216458__F2 CD47–SIRPAlpha-targeted therapeutics: status and prospects CD47 GHR PMC4768069__F2 Bioinformatics analyses reveal changes in expression of genes associated with the Death Receptor Pathway TANK TRADD DIABLO TRAF2 HTRA2 FADD PMC6202673__F1 Proposed model of airway tolerance TLR4 IL33 CCL20 IL25 IRF4 PMC2581748__F2 Activation of the mammalian target of rapamycin (mTOR) pathway can result from numerous glioma-associated genetic changes NF1 PTEN MTOR RHEB PMC5472795__F8 Anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites RNF168 CDC14B RNF8 RIF1 APC RAD51 ATR BRCA1 USP1 PMC1525002__F4 Sequence logo [41] of putative regulatory motif ENO1 ENO2 ADH5 HEL-S-4 HEL-S-68p PMC6434684__F1 Sonic Hedgehog Pathway SUFU PTCH1 SHH SMO PMC7764417__F2 Putative model for the development of (cardiac) lipid-induced insulin resistance IRS1 CD36 PMC4972113__F1 Mechanisms of tumor responsiveness to statins ARF6 EPB41L5 MVP HMGCR PMC5810242__F10 The interrelationships among p-AMPK, p-mTOR, p-ULK1, autophagy and apoptosis ULK1 BCL2 MTOR PMC3281571__F2 MTOR pathway PML ULK1 PTEN MTOR MAF1 EIF4B SGK1 EEF2 ARHA RAC1 EIF4E TNF DEPTOR IRS1 RHEB MLST8 TSC2 SLC7A5 RICTOR TSC1 GRB2 YY1 SLC3A2 GRB10 BNIP3 PMC2768039__F2 Genetic Basis for Kidney Cancer VHL RBX1 TGFA PMC3281571__F1 Simplified view of the mTOR pathway TSC2 TSC1 EIF4E MTOR IRS1 RHEB MLST8 PMC3341446__F1 Illustration of the PI3K pathway signaling pathway TSC2 TSC1 FOXO3A PTEN PMC3335670__F3 Action of the enteropathogenic yersiniae Ysc T3SS effectors (Yops) on host cell signaling and survival TLR4 SRC ARHA RAC1 CDC42 PMC12158951__F1 Two main mechanisms of Fn promoting CRC proliferation TLR4 APC LRP5 LRP6 MYD88 BCL9 PMC7289953__F1 Mechanisms underlying experimental liver transplant tolerance TLR4 MSC CD80 PMC8601819__F3 Naringenin: A Promising Therapeutic Agent against Organ Fibrosis IL18 SMAD2 SMAD4 RHO TNF PMC5409051__F5 Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats INSRR ANGPT4 UNK DAGLA PLA2G4C PMP2 ACD HEL-S-22 PMC6562953__F1 RKIP protein as a signaling modulator in lung cancer NF2 SHH STAT3 PMC8591231__F5 Review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury BAD IGF1R IGF1 IRS1 FADD BAX PMC2871498__F9 Working model for S1P/SK/S1PR interplay during acrosomal exocytosis ABCC1 SKI SPNS2 PMC3071501__F10 Genes mapping to KEGG pathway for hedgehog signaling SUFU RAB23 SMO PMC10586346__F3 Osteogenic differentiation-related signal pathway diagram RUNX2 DSPP ACE2 PMC6332930__F2 Interferon (IFN)-dependent IFN stimulated gene (ISG) transcription through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling STAT1 STAT2 IRF7 IRF8 IFNGR2 TYK2 IFNAR2 JAK1 IFNAR1 IFNGR1 IRF2 IFNLR1 PMC5817353__F1 Subcellular compartmentalization of the Fe-S cluster and Moco assembly processes FDX1 MOCS1 ABCB7 FDX2 CIAO1 ISCU BOLA2B ISCA1 CIAPIN1 MOCS2 MMS19 SUOX XDH MOCS3 ISCA2 BOLA1 PMC3289598__F1 Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background CS AQP1 PMC6600680__F7 Mitochondria-mediated apoptotic signaling pathway by JNK and p38 CASP3 BAD CASP9 HTRA2 BAX PMC8212062__F7 Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway CD34 BMP4 PMC3283059__F2 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway displaying transcripts in mitogen-activated protein kinase (MAPK) signaling pathway NF1 MOS DAO MAX FLNA EGFR ECSIT RAF1 TNF MEF2C JUN ERI1 PMC3283059__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway display transcripts in cell cycle pathway CDC20 E2F4 CDC6 SMAD2 APC SMAD4 DBF4 RAD21 PCNA SKP2 MYT1 PMC3428242__F1 Simplified schematic representation of the mammalian target of rapamycin (mTOR) signaling pathway.Notes: Red, pathway inhibitor; Green, pathway activator; Blue, mTOR complex protein.Abbreviation: NOS, not otherwise specified TSC2 RICTOR TSC1 RHO PTEN MTOR RHEB MLST8 PMC9002269__F1 Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors MYB CAMTA2 CAMTA1 PMC8102909__F7 Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120JRFL CCR5 EGR1 IL18 CXCR4 OTP PMC8346999__F10 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases RAB39A NLRP1 UBR5 UBR1 UBR4 IL1B PMC9488848__F2 Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease GRB2 PTEN MTOR PMC2063819__F7 The newly identified NT3-activated signaling pathway TAMALIN RAC1 COIL ARF6 PMC5971440__F15 Arteriosclerotic G3BP1/RIG-I signaling in aortic VSM, a working model NFATC4 RUNX2 LRP6 RAC1 MAVS CDC42 PMC11394960__F8 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the lungs in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC11394960__F7 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the liver in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC11843905__F14 STRING network of FREM2 EGF CDH24 NPNT GRIP1 SMTNL2 OMA1 RYK LEO1 NRP2 UQCRFS1 TACC2 ZDHHC21 ERBB4 MAST2 FAM221A FEZ1 OR6T1 TFAP2A AJAP1 HMCN2 XPNPEP3 CCDC63 EGFL6 FREM2 HEL-S-75 ERBB3 FREM1 ITGB1 HMCN1 KRT75 PITRM1 TRPC4 ERBB2 TIMM10 IGFBP2 NLN THOP1 PMC11394960__F9 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the kidney in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC5850959__F7A Transcriptomic data shows immunometabolic effects of vitamin D HEL-S-62p E2F4 HDAC3 HEL2 HEL-S-1 GSK3B CCNH SMAD4 CDK6 CCND2 SMC1A ATM F2 CCNB1 C7 MEN1 HDAC2 PRKDC YWHAG HDAC8 HDAC7 APC ARF1 HDAC1 YWHAQ EP300 C6 ATR HEL-S-93 TGFB1 LAT PMC8346999__F11 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR1 ATR RAD18 SDE2 PCNA PMC7589192__F2 Common signaling pathways of epithelial-to-mesenchymal transition based on Albrecht et al RHO CAD PMC11034122__F7 Different pathways activated in A XK MVD RPE PMC11034122__F6 Comparative physiological, biochemical, metabolomic, and transcriptomic analyses reveal the formation mechanism of heartwood for Acacia melanoxylon CAD PAH PMC6052114__F7 Models of SLC9C1 gating by voltage and cAMP HEL-S-11 GC CA11 SLC9C1 PMC5864870__F1 Anti-gliomagenic effects of different psychiatric and non-psychiatric drugs as demonstrated via in vitro studies PLK1 EGFR BCL2 MTOR JUN PMC5372812__F1 Schematic representation of the general phenylpropanoid pathway leading to major branches of flavonoid biosynthesis and their possible interaction with miRNAs STS MVK IPMK CSA2 PMC4546649__F6 Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse KIF12 PKHD1 PKD1 CYS1 TCF2 PMC7492232__F1 Proposed mechanisms of sex-related susceptibility to COVID-19 ACE2 TMPRSS2 PMC8526435__F2 Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication STAT1 EGF SOCS3 EGFR PIAS1 SRC TYK2 JAK1 ACE2 SOCS1 STAT3 PMC4833573__F2 Pediatric Gliomas as Neurodevelopmental Disorders NF1 FGFR1 BRAF PTPN11 MTOR CDKN2A PMC12135226__F2 Lactylation NUSAP1 HMGB1 YTHDF1 EP300 HEL-S-87p MRE11A HEL-S-133P HEL-S-281 PMC5730868__F1 Self-renewal pathways in CSCs (A) Wnt signaling pathway, (B) SONIC Hedgehog signaling pathway, and (C) Notch signaling pathway PTCH2 SOX2 SUFU APC PTCH1 SHH SMO PMC3176054__F5 Proposed model of early pathologic events occurring in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 male mice defined by changes in gene expression JUP DSG2 SRC PMC2839454__F2 Too Old to Fight? Aging and its Toll on Innate Immunity CD14 RAC1 TLR1 PMC11773722__F9 Graphical summary of disrupted immune and structural milieu in the intestinal epithelium of Mpj and Lpr mice KIT PDC IL16 CD80 PMC8056044__F6 Illustration of neuronal and astrocytic pathways implicated in the disease according to the top scoring genes according to our integrated ranking UBE2J2 HDAC3 SRGAP1 GCS1 APP PRKCSH BDNF PFN1 EDF1 PMC3209350__F1 Synthesis, utilization, and regeneration of glutathione and regulation of mTORC1 activity TSC2 TSC1 GPX1 RHEB PMC7196551__F1 Natural products targeting different cell signaling pathway IGF1 ALK SMAD2 EGFR ROS1 GATA3 CFTR PMC3966314__F3 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance and EMT MCM3 ZEB2 DHFR DTL PMC3436147__F8 Putative mechanisms of the effect of the Kv1 KCNA3 BCL10 MBP LCK ZAP70 CCR7 LAT FOXP3 PMC3258214__F1 Bcl-3 signaling cascade IL10 CYLD TNF STAT3 PMC2916958__F7 Proposed model for the role of NOX4 and DUOX2 in promoting cell cycle entry DUOX2 CCND1 NOX4 CDK4 PMC4601608__F4 Schematic drawing summarizing the physiological regulation of the melanocortin pathway and pathological findings in the in Ankrd26−/− mice CORT POMC MC4R ARC STAT3 PMC8440041__F2 Mucus targeting as a plausible approach to improve lung function in COVID-19 patients MARCKS AHR RFX3 EGFR IL8RB MUC2 PMC8277948__F10 Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630 FAP KLF6 PMC3840254__F8 Summary of proposed pathway leading from TGFB1 receptor binding to ROS generation TSC2 NOX4 MTOR ROS1 SIRT1 UCP2 PMC9455275__F5 Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma HEL-S-30 MYC CYC1 CIT GLA POLI PMC9085840__F2 Pathways of mitophagy OPTN TBC1D17 PMC5239781__F1 Complement activation HEL-S-62p CD59 C4B_2 CD46 MASP1 FH C6 CD55 PMC4081624__F1 IGF signaling pathway SST IGF1R IGF1 IGF2 GHR GHRHR IGFALS IGF2R GHRH PMC12190578__F2 Simplified schematic of PpIX synthesis in heme biosynthetic pathway ABCB6 CPOX ABCG2 PMC7003708__F1 Mass spectrometry–based proteomics of mdx fibro/adipogenic progenitors (FAPs) reveals a significant alteration of key metabolic pathways CRAT CPT2 COX7A2 COX5A MDH2 NDUFV3 ACADS PDHA1 HEL-S-304 NDUFA9 RPIA UQCR10 OGDH SUCLG2 PDHX PGAM1 SDHD NDUFS8 RPE HEL-S-133P HK2 PGAM2 SDHA SDHB HEL-S-281 ENO3 NDUFS4 SDHC NDUFA6 ENO1 DLD NDUFC2 HEL-S-68p NDUFB7 NDUFB3 ENO2 SUCLG1 ACLY HEL107 CS HADHB NDUFA5 ACAT1 FH ACO2 NDUFS5 PFKP NDUFB6 MAL FASN COX7A1 NDUFS6 NDUFV2 NDUFA7 COXFA4 PFKL IDH3B HEL-S-87p HEL-S-162eP NDUFA2 NDUFB4 ACADL CPT1A UQCRH NDUFA3 ACADVL CHKB SUCLA2 ECHS1 PMC5547213__F1 Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy ULK1 ATF4 AMBRA1 PMC2878012__F5 Model for the role of SQSTM1 in regulating the integrity of the Keap1-Nrf2 cell defense pathway KEAP1 SQSTM1 PMC5373463__F1 Regulatory networks that control intrarenal RAS activity FGF23 NR1i1 PMC9577257__F2 WNT signaling at the intersection between neurogenesis and brain tumorigenesis DAAM1 DAAM2 APC RHO RAC1 CDC42 PMC10417677__F3 Anti-inflammatory mechanism of MBPs NLRP3 IL6 TNF PMC8876822__F3 Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism EGFR VWF ADAM10 PMC3412259__F1 This diagram of BCR/CD19-initiated signaling shows two key outcomes of PI3K activation BTK RICTOR BCR BASH SYK MTOR CD19 PMC5873983__F1 Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: a one-carbon metabolism candidate gene study HEL-S-61p AS3MT MTR MTRR TYMS TCN2 MTHFD1 FOLR1 SLC46A1 ASL SLC19A1 PMC4360475__F6 Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa EGF GPX4 NCL GH1 PRDX5 SP1 SDHB HEL-S-162eP PMC7781331__F2 WormPaths examples PCK1 FBP1 FAT1 FAT3 HEL-S-68p HEL-S-49 HEL-S-26 AMH PDHA1 GPD2 PCK2 ART1 GPD1 PMC2839169__F1 Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades EGFR MAPK1 PTEN MTOR PMC8989677__F8 Cartoon of mode of action of BNT162b2 in vivo PDC GC RIPK3 IFNAR2 IFNAR1 IFNG PMC4861419__F6 Schematic illustration represents the potential signaling transduction mechanism by which cancer cell-derived exosomes prevent monocyte apoptosis CASP3 CASP10 CASP8 PMC6949840__F3 (1) TNFA, and IL-1B can induce the expression of TGFB IL16 NR1i1 SMAD2 SMAD4 PMC3921549__F1 Carcinogenetic pathway and classification of colorectal cancer BRAF APC PMC8511458__F2 Interplay Between Non-Canonical NFKB Signaling and Hepatitis B Virus Infection APOBEC3A APOBEC3B TRAF3 RELB CD40 LTBR PMC11311387__F4 Involvement of p53 in cell stress responses and glycosylation-related pathways and the relationship between p53 glycosylation and cancer progression TIGAR ENTPD5 FUCA1 PMC12058482__F3 Molecular mechanisms of epithelial-mesenchymal transition EGF SMAD2 SMAD4 CDH2 COL1A1 PMC12058482__F1 Interaction between inflammatory response and alveolar epithelial cell injury NLRP3 IL33 STAT3 PMC3875243__F1 Characterization of Negative Feedback Network Motifs in the TGFB Signaling Pathway KY SI CIT PMC6712945__F5 Schemes for nanoparticles loaded with specific agents to target TAM signaling pathways CCR2 TLR7 NPS PMC7577085__F2 Signaling pathways activated by MSP and RON NLRP3 TRAK1 MHC2TA TLR4 USF1 GRB2 TRAF6 PMC7487068__F7 Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy NLRP3 CHST6 IL1B PMC8627910__F2 Fragment of the gene network, containing genes associated with PIN1 and genes related to the auxin signaling pathway PIN1 COPA PMC7140485__F1 Canonical and non-canonical pro-fibrotic pathways of transforming growth factor B (TGFB) and Wnt and the pro-fibrotic interleukin 11 (IL-11) pathway GRB2 IL11 PMC2342468__F1 Cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice PLN TNC RYR2 PMC3101043__F2 Endogenous and exogenous regulators of TLR activation TBK1 TRAF6 MYD88 TIRAP PMC6125217__F1 Nodal and Shh Signaling BOC CDON DISP1 NODAL CRIPTO SMAD2 SMAD4 GAS1 PTCH1 GLI3 SHH SMO FOXH1 PMC3985001__F1 The CNS-immune system crosstalk ChAT NPY AgRP TNF VIP PMC9103744__F6 Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling RICTOR PDPR APP PMC8844185__F3 Future Directions in Diagnosis, Prognosis and Disease Monitoring of Adrenocortical Carcinoma: Novel Non-Invasive Biomarkers HSD17B3 CYP17A1 CYP21A2 CYP11B2 PMC4450221__F2 Mechanisms underlying the developmental programming of NAFLD TLR4 IL6 IL1B FASN PMC8733707__F7 ENO3 Inhibits Growth and Metastasis of Hepatocellular Carcinoma via Wnt/Beta-Catenin Signaling Pathway MMP7 ENO3 MMP2 MMP9 GSK3B CCND1 PMC12058482__F4 Severe acute respiratory syndrome coronavirus 2 infections and epithelial-mesenchymal transition TLR4 SRC ACE2 TMPRSS2 STAT3 PMC5187527__F4 Mechanism of estradiol-dependent repression of GD3S in ER-positive breast cancer cells TNF ST8SIA1 PMC2915454__F4 Pathways underlying absorption of cholesterol from the intestinal lumen and its delivery to the liver ABCG8 ABCG5 NPC1L1 MTTP ACAT2 PMC11977258__F4 OB-EC communication RUNX2 BMP2 VWF BMP7 PTH TGFB1 BMP4 PMC8938281__F10 MiR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells SMAD2 SMAD6 SMAD4 SMAD1 DKFZp781O1323 ITGA2 PMC4196276__F5 Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets SHC2 EGF IGF1 GRB2 SHE PMC1783813__F3 Physiology and immunology of the cholinergic antiinflammatory pathway CD14 HMGB1 TLR4 TNF PMC7907897__F2 NRF2 regulatory mechanisms.A) three reported negative regulatory mechanisms of NRF2 ABCC3 GCLM GPX4 KEAP1 FTH1 LIPH AKR1C1 XBP1 BRCA1 DKFZp686F0183 ACOX1 HEL-S-26 MAF DPP3 AHR BRCA2 GPX2 ABCC1 NOTCH1 HEL-75 RAD51 ABCC5 ABCG2 ABCC2 PMC6213406__F1 Putative anticancer effects of MTF exemplified by molecular and cellular key events CCND1 IPMK MTOR STAT3 PMC8557262__F1 Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence TLR7 GC ACE2 PMC2710522__F1 Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data EGF NRG3 BAD LIMK1 RIN1 ERBB3 PTEN MTOR RHEB STAT1 RINL PAK1 ERBB4 BTC ERBB2 GRB2 SOS1 TGFA NRG4 STAT3 VAV2 PMC5396097__F3 Autophagy-mediated regulation of macrophages and its applications for cancer CCR2 TLR4 IL6 CCL2 MTOR IL6R PMC5396097__F1 Autophagy-mediated regulation of macrophages and its applications for cancer ULK1 PI3 SH3GLB1 AMBRA1 UVRAG MTOR ATG14 PIK3R4 PMC2002564__F1 Arterial–venous specification in the developing embryo SHH FOXE1 EPHB4 PMC7106955__F1 Main mechanisms of ferroptosis GPX4 ADA TFRC SLC3A2 PMC3406705__F8 Hypothetical model elucidating the regulation of phosphorylated FAK expression through an integrin A5 and B1-mediated MEK-ERK1/2-dependent pathway after ESWT ITGB1 PMC11882760__F3 DUBs on periodontal inflammation and bone resorption NLRP3 USP12 CD9 CD47 IL18 SEC23B OTUD1 CYLD BMP2 TRAF6 TRAF4 STAT3 PMC8396359__F4 Duality of Caspases in Cancer, as Told through the Fly ATM SSB ATR PMC4586293__F2 Neurohormetic Phytochemicals: An Evolutionary - Bioenergetic Perspective TSC2 TSC1 IGF1 FOXO3A MTOR SIRT1 RHEB PMC5428057__F6 Schematic overview summarizing the functional significance and regulation of COX-2 in PDAC EGF EGFR GRB2 SP1 PMC5745276__F1 Wnt pathway can be classified as canonical and non-canonical ZNRF3 RNF43 GK3 PMC3117391__F3 Pathway for getifinib and docetaxel to generate the synergistic effects on KRT8 PIN1 SOCS3 EGFR MAPK3 MAPK14 FGFR3 RAC1 RRAS2 HRAS BNIP2 CASP3 SRC BCL2 MAPK1 RAF1 JAK1 SOS1 JUN STAT3 PMC5789355__F1 Signal transduction through the mTOR complexes TSC2 TSC1 PTEN EIF4E CAD MTOR DEPTOR EIF4B SGK1 RHEB STAT3 PMC6879499__F3 Construction of pathway map and PPI interaction map PTGFR KEAP1 GSK3B AKT1S1 HIF1A RYR2 PDPK1 NF1 PTGER1 MDM2 DVL2 MAPK1 NAMPT CRABP2 CDKN1B EIF4E DEPTOR IRS1 DDIT4 STRADA PLCB1 RHEB MLST8 TSC2 RICTOR TSC1 PDE4B RAP1A RPS6KA1 GRB2 SIRT1 RB1CC1 HEL-S-7a PML EIF4A1 EEF2K ULK1 BRAF PRR5 PPP2R1A PTEN PARG EIF4EBP1 MTOR FZD1 RPTOR INSR PPARGC1A LPIN1 SIRT6 EIF4B FOXO3A PARP1 ARHA RAC1 MAPKAP1 EGLN1 HEL-S-69p NFKBIA CREBBP EP300 PIK3CA BNIP3 PPARG HEL-S-93 PXN CAMKK2 PMC5745276__F3 Cross-Talk between the Wnt, Notch and Sonic Hedgehog Pathways- Beta-catenin can drive activation of Notch signaling by increasing expression of the JAG1 gene, which encodes the Notch ligand Jagged1 SHH GK3 SFRP1 SMO PMC7106955__F3 Hippo signalling pathway FACL4 NF2 NOX4 TFRC CAD EMP1 TF PMC8820687__F1 Brain as a source and a target of prolactin in mammals PRLR GRB2 SRC PRL PMC3645678__F3 Involvement of Cdc42, Rac1 and RhoA in vesicle trafficking, cellular transformation, invadopodia formation and metastasis RHO RAC1 CDC42 PMC8108463__F3 Endogenous retroviruses in the origins and treatment of cancer IRF7 TLR3 MAVS PMC9251540__F1 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review RUNX2 SMAD2 APC FGF2 GSK3B LRP5 CCND1 LRP6 SFRP1 WNT10A PMC9251540__F3 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review NLRP3 RAN IL1B CASP5 GSDMD CASP4 PMC9251540__F2 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review NOTCH2 HES5 NOTCH4 HEY2 NOTCH1 NOTCH3 HES1 PMC8885627__F1 Macrophages and Metabolic Reprograming in the Tumor Microenvironment CXCL8 CSA2 CXCL12 PMC9579717__F6 Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling CLIC1 DEPTOR MLST8 PMC3146245__F2 Genetic model for nuage assembly and piRNA pathway genes in mice MAEL TDRD7 TDRD6 TDRD1 HIG-1 MOV10L1 PMC5741148__F1 Regulation of the FoxO1/3 activity by phosphorylation IRS4 FOXO3A F3 IRS1 FOXO1 PMC6349168__F1 Molecular interactions in Immunometabolism governing lipid metabolic disorders UNK STAT3 CD36 PMC125566__F7 Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 APC PMC6400832__F1 The nutritional sensing O-GlcNAcylation PGM3 OGA OGT PMC4998060__F2 Signaling network that regulates ISC activity in response to injury HEL70 EGFR PMC2206598__F4 Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study JUP REN EGFR RAN EPHA2 AK1 PMC4571978__F1 A, diagram of the workflow of mitochondrial proteomic studies SET CTRL KIN CAD PMC2075270__F1 Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle EEF2K PI3 TSC1 EEF2 INS MTOR IRS1 PMC4038907__F4 Progesterone and breast cancer EGF CDK2 GRB2 CCND1 SP1 PMC4143405__F5 Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer SET XBP1 FOXO1 CCND2 BCL6 HES1 RET PAX5 NOTCH1 SHH CCND1 ME3 IRF4 PAX1 PMC8222665__F3 Tumor-Associated Macrophages: A Potential Target for Cancer Therapy SIRPA CD47 CCR2 CXCR4 CD40 CXCL2 CCL2 CXCL12 PMC6293973__F1 The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration HMGB1 PMC5974440__F2 Regulation of stemness in the intestinal stem-cell niche EGF EGFR GSK3B LRP5 GPR49 PMC9691389__F6 Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis NAPSA AP2A1 AP2A2 FCGR2A SMAD2 ERBB4 HGS LDLR HGSNAT AMPH TPP1 FCGR2B FCAR GABARAP CD68 EPN2 CHMP4A ZFYVE9 RAB4A VPS28 FCGR3B PS1TP5BP1 HLA-DOA HLA-A GABARAPL2 THBS3 ACP5 ARF6 SLC11A2 PMC5966388__F6 Dysregulation of the MiR-449b target TGFBI alters the TGFB pathway to induce cisplatin resistance in nasopharyngeal carcinoma TGFBR1 TGFBR2 PTEN TGFBR3 CDH2 TGFBI PMC8586445__F1 T-Cell Metabolism in Graft Versus Host Disease SLC3A2 MTOR HK2 PMC7492601__F7 Biological mechanism of lncRNA C1RL-AS1 in GC GSK3B PMC11054595__F2 Mechanisms or pathways associated with sepsis-induced ALI TLR4 AQP1 MYD88 BAX PMC5431011__F7 Glycerophospholipid metabolism is induced in parasitized A PGS1 CS CDS1 LPGAT1 PC AGPAT3 PLA2G2E LPL TG GPAM HEL-S-5 PMC10380468__F2 Investigation of the Effects of Metallic Nanoparticles on Fertility Outcomes and Endocrine Modification of the Hypothalamic-Pituitary-Gonadal Axis GNRHR EGR1 EGFR HBEGF FSHB LHB PMC4115674__F1 Ras/MAPK signal transduction pathway NF1 CS BRAF GRB2 SPRED1 SHOC2 SOS1 CBL PMC6747293__F1 Stress-induced senescence ATM CDK2 CDKN3 CDK4 ATR CDK6 PMC111167__F1 BR biosynthesis pathway CS GH1 CPD PMC3193406__F3 NIK stabilization as a mechanism of non-canonical NFKB signaling ZFP91 TRAF3 TRAF2 PMC3193406__F2 Positive and negative domains regulating p100 processing SKP1 REL RHD RBX1 PMC3193406__F1 Canonical and non-canonical NFKB signaling pathways BCR RELA RELB CD40 LTBR PMC5136497__F3 Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis IL1A IRF7 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR8 COX2 TLR7 TLR4 IRF-1 PMC12151073__F2 Mechanisms by which lactate modulates the innate immune responses COX2 TLR4 TRAF6 MYD88 PMC4594188__F1C Significant signaling pathway networks in each group PITX2 MYC DEFA1B REL SP100 PMC5817863__F1 Schematic view of the circadian pathway CRY1 TIMELESS RORB hCG_2014051 RORA NPAS2 NR1D1 PER1 PMC4594188__F1E Significant signaling pathway networks in each group RARA CACNG2 ARFGEF2 PMC4594188__F1A Significant signaling pathway networks in each group PROC MYC HEL-S-99n SP1 PMC9597979__F7 Transcriptional regulation mechanism of wheat varieties with different nitrogen use efficiencies in response to nitrogen deficiency stress EBF2 TF PMC5441174__F7 Schematic diagram of the FOXM1/Beta-Catenin complex in human osteosarcoma cells FOXM1 CCND1 TCF4 PMC5056611__F1 SETD1A-induced miRNAs suppress gene expression modules SETD1A EZH2 BTG2 PMC5514447__F2 Low-dose triptolide and aspirin suppress NFKB survival pathways RASGRF2 POSTN MMP11 EFNB2 F2RL1 ESAM FBN1 MAOA HIF1A SOX4 ITGA2 FLT1 HPGD GHR TBX5 SEMA3C SP1 ADM EMP1 RTP3 LAMC2 AFAP1L1 ELK3 BMP6 AKAP12 IL1A MEOX2 DACH1 LAMB3 ENG LAMA3 EDNRB CDKN2B IGFBP2 CD36 ACVRL1 HGF ICAM2 PLOD1 DPP4 CALCRL FOXF1 IER3 CADM1 AHR DLL4 VSNL1 KITLG MFAP2 IL1B HILPDA RAMP2 KIT AQP5 LIF VIPR2 TSPAN7 FGF18 TNFSF10 CD93 JAM2 PMC6221181__F1 Glucocorticoids regulate NK cells and ILC1s functions upon MCMV infection TSC22D3 RHPN1 IFNG PMC9010746__F1 Controlling neural territory patterning from pluripotency using a systems developmental biology approach MAX NODAL SMAD2 JAG2 SMAD1 DKFZp781O1323 PMC4862604__F4 Repair Pathway Choices and Consequences at the Double-Strand Break PALB2 AHR POLE BRCA2 RAD51 BRCA1 PMC3295626__F1 JAK-STAT intracellular signaling pathway in myelofibrosis EPO MTOR SOCS1 PMC4862604__F3 Repair Pathway Choices and Consequences at the Double-Strand Break PALB2 POLE FBXO18 BLM RTEL1 BRCA2 RAD52 RAD51 FANCM BRCA1 PMC9097270__F6 DNA repair, recombination, and damage signaling GEN1 APAF1 BCL2 RAD51 NEDD8 MSH4 PMC7730291__F1 Wnt–FAK signaling crosstalks and inhibitors APC LRP5 GRB2 SRC LRP6 PORCN PMC4862604__F2 Repair Pathway Choices and Consequences at the Double-Strand Break RIF1 ATM BRCA1 PMC9066194__F4 Function and Regulation of SAPCD2 in Physiological and Oncogenic Processes EZH2 PMC8577250__F1 Low-intensity pulsed ultrasound stimulates proliferation of stem/progenitor cells: what we need to know to translate basic science research into clinical applications CCNA2 TLR4 CCNB1 CCND1 CNN2 REL MTOR CCNE1 PMC6522871__F2 Small molecule inhibitors and the ALK-Smad signaling pathway SMAD2 SMAD4 PMC7033031__F9 TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching CXCL1 TRPV4 TLR4 CCL2 PMC3723343__F3 Cripto/GRP78 modulation of the TGFB pathway in development and oncogenesis NODAL CRIPTO SMAD2 SRC PMC6466717__F2 Biosynthetic pathway of Plasmalogens FAR1 HEL-S-5 PMC11546748__F2 Molecular and hormonal pathways contributing to insulin resistance in gestational diabetes IL18 IL6 CCL2 MTOR PMC5706779__F3 Novel Mechanisms and Functions of Complement HEL-S-62p TNF RPE CP PMC9923233__F7 Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network UBE3A HLA-DPA1 EGF CAMK2D SYNRG WASF1 DNM3 USP28 XPC ARF1 TTN GORASP2 ZNF148 GCS1 ZBTB16 CYFIP2 CYFIP1 VAMP7 USP1 PMC2814418__F8 VDR-dependent and auxiliary pathways that lead to deltanoid-induced monocytic differentiation of myeloid leukemia cells CD14 NR1i1 EBP PMC4851692__F4 Effects of C10 on gene expression ACADVL PDK3 NDUFC1 PDK4 PCK2 PMC7137344__F1 Functional alterations and HSC aging mechanisms TSC2 GSK3B CD160 TXNIP SELP JAK1 MTOR ROS1 RHEB PMC6771146__F6 String network of proteins (encoded by the differentially expressed genes (DEGs)) involved in signalling pathways KIT KITLG ERH TCF7L2 PRL FRZB PMC6771146__F4 Co-expression analysis of genes overexpressed in Puławska pigs, characterized by high feed conversion values COX1 S100A10 ATP6 ND4L CYB ATP8 COX2 ND6 ND3 ND1 ANXA2 ND5 ND4 FGL2 PMC11593353__F2 Differential Gene Expression Associated with Idiopathic Epilepsy in Belgian Shepherd Dogs STAT1 STAT2 IRF9 PMC4384327__F3 APP protein-protein interaction networks SYNRG P2RX7 LPAR2 LRP8 CCL7 ACHE SPN DLG4 CXCL16 SORL1 HGS APP LYPD3 APOE CD14 SNCA RELN STXBP1 FTL FPR2 FLOT2 LAMA1 HSPG2 KALRN ADA CXCL12 PMC5630445__F3 The role of toll-like receptor 4 in tumor microenvironment CD14 TLR4 IL1B PMC7801279__F2 Drugs treat VaD through regulating inflammation-related signaling pathways NLRP3 TLR4 MYD88 IL1B SIRT1 PMC7842189__F2 Microglia-Tissue Consensus Module Microglia Disease Time Course and Pathway Annotation TLR9 NCF4 DOK1 INPP5D NOTCH1 BHLHE41 B2M CST7 RAVER1 DEF6 PSD4 c-fgr PLAUR STAT2 PTBP1 IL1RN SNX9 IFNAR2 SDC3 ARHG NFKB2 ITGAX IFIH1 CDK9 MAVS RGL2 CDC42 PML VASP DHX58 EBI3 MFNG ARHGEF2 PLD4 PFN1 CEBPB CD81 CXCL13 FCER1G TLR7 SEMA4D LPIN1 LILRB4 SCARB2 PAF1 ARHGDIB CD14 RUNX1 RRAS QSCN6 TLR1 LCP1 PKN1 PS1TP5BP1 CTSZ TYROBP PTPRC PSEN1 CTSC HEL-S-42 CD22 TYK2 ARF6 TPT1 PLEKHO1 SOCS1 PDCD1 PMC4170139__F4 Late signaling events in de novo cytokine/chemokine production FYN BCL10 GAB2 LYN GRB2 TRAF6 SYK MYD88 TNF MTOR LAT MAL PMC4085879__F2 Targets in T-ALL: PI3K/AKT/mTOR, cyclin D3:CDK4/6, BRD4/MYC CDK4 PTEN MTOR CDK6 BRD4 PMC8690056__F1 Nicotinamide and acute kidney injury NAPRT NAMPT HEL-S-90n SARM1 PMC11544004__F9 Impact of the environment on NK cells: Phytoncide model IDO1 TPH1 AHRR AHR CYP1B1 ASB2 CYP1A1 IFNG PMC8021541__F7 LncRNA H19 regulates sensitivity to EGFR‐targeted therapy through different mechanisms EGFR SRC PMC3944232__F7 Schematic illustration of LEF1/CYLD and cIAPs in the modulation of RIP1 deubiquitination and triggering of apoptosis via caspase-8 LEF1 CYLD PMC11544004__F5 Dynamics of activation signaling in NK cells in contact with cancer and stressed cells MICB VAV1 CD48 ULBP1 BAG6 RAC1 CRK FOXO1 CBL IFNG VAV3 ULBP2 ZAP70 GRB2 SRC MICA ULBP3 SYK LAT VAV2 PMC11955616__F4 Function and Regulatory Mechanisms of the RIG-I Signaling Pathway in Lung Cancer (By figdraw) TBK1 IRF7 IRF3 MAVS PMC8466094__F2 Crosstalk between Autophagy and Inflammatory Processes in Cancer SQSTM1 IRGM ATF2 MYD88 MTOR PMC11955616__F3 Function and Regulatory Mechanisms of the TLR Signaling Pathway in Lung Cancer (By figdraw) TLR8 TLR5 TLR7 TLR4 TLR9 IRF7 IRF3 MYD88 TLR1 TLR10 TLR3 PMC11955616__F2 The cGAS-STING Signaling Pathway in Lung Cancer Immunotherapy (By figdraw) TBK1 ESYT3 CGAS WEE1 IRF3 NR1D1 GPR162 PINX1 TET2 PMC8021541__F2 LncRNAs sponge microRNAs and then regulate radiosensitivity through different signaling pathways CARM1 MMP2 MMP9 EGFR PTEN HOXA10 CDH2 MBNL3 PMC5225216__F2 Hypothesis of intercellular energy relocation triggered by gut microbiota RAF1 TIRAP PMC5225216__F1 Intracellular energy relocation in fat body cell of Drosophila and immune cell of human IRF3 MYD88 TIRAP PMC4426903__F3 Evolutionary Changes in Promoter and Enhancer Activity During Human Corticogenesis EGF FBLN2 NODAL EGFR SMAD2 FBN1 SMAD4 FOXC2 COL1A1 BMP4 FBLN5 TBX18 SOX13 COL1A2 TGFBR3 SP1 COL18A1 TBX2 SMAD6 ENG NID1 NID2 COL13A1 SMAD1 DKFZp781O1323 COL4A1 PMC7550584__F3 Schematic pathway for DEP-mediated olfactory dysfunction CYP26B1 CFAP69 SYNPR IL6 IL1B PMC4827226__F7 Working model of how the EphA1-activated SDF-1/CXCR4 signaling promotes EPCs’ homing to HCC neovascularization CXCR4 ELL PMC7135251__F4 IPA cellular view of: A) 15 affected molecules in the significant Protein Ubiquitination pathway USP15 RUNX2 NODAL TRAF6 NR1i1 TLX2 USP14 UBE2W APP UNK GSC LPP PSMC4 HEL-117 SKI HEL-S-89n RUNX3 IRF7 PITX2 UBE2H SMAD6 DNAJC2 UBE2E3 HDAC1 STUB1 GRB2 HEL-S-276 USP47 SKP2 ELL ANAPC10 CDC42 FOXH1 PMC7846875__F10 Schematic drawing to illustrate the inhibitory effect of GPs on NFKB and TNFA signal pathway and inhibitory of apoptosis of endothelial and epithelial cells TLR4 VCAM1 MYD88 IL1B PMC5854325__F1 Death receptor-mediated apoptosis signaling TRADD TNF FADD PMC7822913__F7 Hypothetic model of Abcc6 function in cholesterol homeostasis of mice PCSK9 ABCB4 FDPS LPL ABCB11 IPP APOE PMC9604914__F2 Bruton’s Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis PLCG1 BTK BCR BASH LYN SRC SYK MTOR CD79A CD19 PMC3899973__F1 Canonical signaling of muscarinic receptors EGF FYN EGFR SRC PMC2761207__F1 Major pathway of the conversion of propionyl-CoA into succinyl-CoA in human cells MCEE MMAA MMACHC PCCA PCCB CBL PMC4352295__F3 Co-regulation analysis among 6 potential internal control genes (ICGs) RPLP0 TUBB FOS MYC TNF PS1TP5BP1 HEL-S-69p IFNG PSEN1 APP MBD2 IL4 GTF2B PMC3353386__F5 NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways HLA-A IFIT3 HLA-E NFE2 CDA TAP2 CTSS IRF-1 PSMB10 PMC4259949__F1 Base-excision repair POLE OGG1 PMC7099013__F2 Ingenuity pathway analysis of drug pharmacodynamic targets, associated immunophenotype markers and topo II GPR34 STAB2 HLA-DRB1 CLEC11A PMC6679095__F2 The PI3K/AKT/mTOR/NFKB Pathway TSC2 RICTOR TSC1 PTEN INPP4B MTOR DEPTOR RHEB MLST8 PMC5528312__F2 RNF8‐ and RNF168‐dependent ubiquitin signaling pathway at DSBs is stimulated by CHD4‐ and p400‐mediated chromatin remodeling RNF168 RNF8 ATM MDC1 CHD4 BRCA1 PMC4614871__F3 Different regulation of DSB repair pathways in somatic cells and XY body RNF168 RNF8 ATM TOPBP1 MDC1 RAD51 ATR H2AX RAD18 BRCA1 PMC2685917__F9 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells BAD IGF1R IGF1 EGFR BAX PMC5216469__F3 Regulatory feedback mechanisms govern Etv2 expression ETV2 CREB1 RCAN1 GATA2 PMC3337715__F1 Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure TSC2 RICTOR BAD TSC1 BCL2 PTEN MTOR ELF4 IRS1 RHEB PMC7278993__F8 Schematic diagram showing the pathways involved in the pathogenesis of vascular calcification (VC) in chronic kidney disease (CKD) SFRP4 WNT3A SFRP5 PMC7328278__F8 Downregulated miR-18b (miR-18b-5p) signaling pathway in fALS linked SOD1 mutation RARB BCL2 HIF1A MEF2C PMC6329466__F1 Neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) receptor signaling pathway and inhibitors NGF NTRK3 BDNF NTRK2 PMC10950892__F2 Shows the benefits of Warburg and molecular signaling TSC2 TSC1 HEL-S-304 PTEN EIF4E HIF1A GLUD1 RHEB HK2 GLS PMC11027102__F3 Blockade of the CD47-SIRPA signaling pathway initiates an adaptive immune response to kill tumor cells SIRPA CGAS CD47 PMC7326282__F8 MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer STK4 LATS1 PMC6285187__F8 Illustration of the working mechanisms for FGF21 prevention of spontaneous and diabetes-induced germ cell apoptosis FGF21 GSK3B MDM2 SIRT1 PMC9207356__F2 Physiological and pathological roles of the Hippo‐YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis VGLL4 LATS1 RHO MOB1A MOBKL1A LATS2 PMC7183688__F1 Participation of TNFAIP3 and UBE2L3 in regulation of NFKB activity under TNFA signaling RIPK1 UBE2L3 MAP3K7IP1 TNFAIP3 PMC7767977__F1 Illustration of the neuroprotective pathways following GHS-R1A activation by AG or ghrelin agonists in neurons and astrocytes MFN1 ULK1 NRF1 IL6 ULK2 DKFZp686F0183 UCP2 HEL-S-162eP TSC2 MFN2 TSC1 SIRT1 TFAM BAX PMC3733118__F2 Genes of innate immunity and the biological response to inhaled ozone TLR4 CD44 IL6 MYD88 TIRAP PMC6384086__F11 Cofilin regulating the actin cytoskeleton and initiating PHEV entry GIP RAC1 CDC42 PMC8983057__F5 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation CXCR1 VCAM1 IL8RB HBEGF RHO PMC4647217__F10 microRNA-31 modulates skeletal patterning PAX2 PAX5 PAX8 PMC7502313__F1 Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review ATF4 EIF2A BCL2 TRAF2 XBP1 PMC8103676__F7 Persistent Giant Algal Virus, with a Unique Morphology, Encodes an Unprecedented Number of Genes Involved in Energy Metabolism SDHC FES SDHD SDHA SDHB HEL-S-5 PMC312742__F9 Role of E2F1 in the DNA damage response ATM E2F2 MDM2 CDK4 ATR E2F3 PMC7911501__F1 TLRs are involved in regulation of Mycobacterium tuberculosis (MTB)-induced production of proinflammatory cytokines TLR4 TLR9 PMC7751760__F5 Cellular pathways regulated by H2S in renal diseases FYN SMAD2 TRAF3 SMAD4 TRAF6 IRF3 MYD88 FOXO1 TAB3 MAL PMC2860693__F8 Simplified model of the signaling pathways regulating radiation-induced bystander effects COX2 LEF1 IGF1R IGF1 ATM IL33 IL6 TNF STAT3 PMC7870688__F1 Crosstalk of canonical and noncanonical TGFB signaling pathways associated with renal fibrosis and inflammation in diabetic nephropathy SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC3012432__F7 Diagram illustrating the PS–Tyro3–Akt cell survival signaling pathways BAD MDM2 TYRO3 BAX PMC10750202__F2 Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation RUNX2 APC SMURF2 LRP5 LRP6 DLX5 HDAC5 MAP3K7IP1 SMURF1 PMC8355060__F1 Transcription Factors CREBH, PPARa, and FOXO1 as Critical Hepatic Mediators of Diet-Induced Metabolic Dysregulation GSK3B CREB3L3 TG PMC9083497__F5 Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells PBRM1 NOTCH1 ARID2 BRD7 ARID1A STAT3 PMC7180296__F6 MetaCore‐based analysis of two major KEGG pathways and their regulatory gene interactions in skeletal and cardiac human fetal mesoangioblasts (MABs) HEL-S-11 AKTIP ATR MYOG CP PMC5937716__F3 Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration SORT1 INA CS SAG SOST TEP1 NAT2 LEP AP1S1 LEPR TRPA1 RAN MECR GABARAP STAR CALY PMC2655244__F8 Proposed model for the signaling pathway of Cao-induced keratinocyte differentiation PIP5K1A PMC5704294__F1 Proposed activation pathway and domain structure of Nrf1 MAF DDI2 NRF1 NGLY1 PMC11967982__F13 C-type lectin receptor signaling pathway (Pathway ID: hsa04625) from KEGG pathways TH NLRP3 FRY CAP1 MDM2 CCL17 TRO ARHA SYK CCL2 PMC11985188__F4 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in p53 signaling pathway in the pathogenesis of esophageal cancer YTHDF2 CDK2 MDM2 PTEN WTAP CPSF4 PMC11985188__F3 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in Wnt/Beta-catenin signaling pathway in the pathogenesis of esophageal cancer FOXP4 MMP2 ZEB2 VEGFA PMC11985188__F2 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in PI3K/AKT/mTOR signaling pathway in the pathogenesis of esophageal cancer SOX2 EGFR MTOR S100A7 PMC5467784__F7 Genes associated to tumorigenesis and/or cancer progression found differentially methylated in HA22T/VGH sorafenib treated cells PRKCZ IKBKG PIM2 ATF2 SMAD2 CSF3R TRIB3 MTOR CCND3 STAT5B MMP3 MMP7 BIRC3 CSF2 PREX1 AIM2 c-fgr FOXO3A NFIB FOS TAOK3 RAC1 NKX2-8 PIK3C2B TSC2 CDKN1A MAP3K14 JAK1 STAT3 PMC6097681__F4 TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts CD14 NPB CTSK TLR9 IFNE TRAF6 IRAK4 MIP RAC1 TNF CPO IL18 TLR7 TLR4 FRK LBP CD40 FADD TIRAP PMC8379279__F1 Model assumptions SRC ARHA PTEN PMC5036929__F2 Drosophila JNK pathway HEL70 TRAF6 RAC1 TRAF4 PMC8103095__F3 miR‐33 regulates hepatic lipoprotein metabolism, fibrosis, and regeneration APOB ATP8B1 CPT1A HADHB CCND1 CROT SKI ABCA1 ABCB11 CDK6 HMGCR CYP7A1 PMC4362780__F3 Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy SSB DDB2 MRE11A APTX PNKP BRCA1 APLF PMC11985188__F7 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in MiR-Axis signaling pathway in the pathogenesis of esophageal cancer VEGFA PTEN PBX3 PMC6492270__F1 In response to injury, there are significant and dynamic changes to the OGlcNAc sub-proteome OGA OGT GSK3B SP1 XBP1 PMC9551334__F9 Acute Manganese Exposure Modifies the Translation Machinery via PI3K/Akt Signaling in Glial Cells TSC2 TSC1 EEF2 SRC PTEN EIF4E RHEB PMC7417625__F2 MALAT1 and miR-200c regulate expression of each other through the sponging mechanism ZEB2 PTEN CDH2 PMC7912185__F2 Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review SFRP4 DKK3 APC LRP5 LRP6 SFRP1 DKK1 DKK2 TG WIF1 WNT10B BCL9 PMC3328896__F2 Cbl-b functions as central gate keeper of T-cell activation PLCG1 FYN APC LCK VAV1 ZAP70 PMC6173124__F1 Role and regulation of host microRNAs in hepatic schistosomiasis STAT1 NR1i1 IL33 STAT3 PMC10253263__F6 Signaling pathway of PNPLA3-I148M-induced activation of LX-2 cells PNPLA3 MFN2 TIMP1 COL3A1 MMP2 ABCG1 HEL-S-44 PMC5027901__F1 Listeria monocytogenes and the inflammasome: from cytosolic bacteriolysis to tumor immunotherapy IRAK1 AIM2 PMC8389007__F8 Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production NLRP3 TLR4 P2RX7 IL1B PMC3970924__F2 Molecular pathology of FLS in RA FOS SRC PTEN TNF JUN PMC6198989__F6 Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk SEMA5A PDGFD EDNRA LMOD1 PDGFRA CDKN2B TWIST1 TGFBR1 TGFBR2 TCF21 PMC7746877__F1 Signaling pathway of EMT APC RHO PMC6612501__F1 TLR4-mediated inflammatory signaling pathway in the rumen epithelium STAT1 TLR4 IRF3 MYD88 IFNG PMC7746877__F2 Therapeutic potential of BMSC-derived exosomes for PF and the potential molecular mechanisms APC RHO PMC3132567__F8 Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1A Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression EGF EGFR VHL PMC8096065__F1 Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks ATM BRCA2 PARP2 RAD51 PARP1 ERCC1 POLN PCNA PMC7689008__F1 Cell adhesion molecules (CAMs) regulate protein synthesis machinery FYN SRC PTEN EIF4E MTOR TF PMC10215085__F9 Hypothetical molecular mechanism model was developed for the influence of starch on the growth and proliferation of B PFKL HCN2 HCN4 PMC9578583__F3 Diagram representing the enzymes involved in the 11 steps of the glycolytic and methylglyoxal pathway and tricarboxylic cycle found in the rumen epithelium of sheep ME1 CS DLD HEL-S-87p HEL-S-68p HEL-S-162eP GLO1 HEL-S-67p LDHD FH HAGH OGDH PDHX HEL-S-133P DLAT PMC6677558__F1 Model of the regulation of light-mediated AS RFWD2 HPR PMC7322557__F1 Molecular connections between components of circadian clocks and the immune system CCL8 CCR2 IL16 S100A8 NFIL3 CCL2 EZH2 RORA PMC3662247__F3 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity TIGAR ULK1 TRAF6 PTEN MTOR DKFZp686F0183 VMP1 PI3 APAF1 MDM2 CASP9 CDC2 UVRAG OPA1 BAX HMGB1 ATG12 AMBRA1 CASP3 TSC2 PINK1 TSC1 RAF1 BNIP3 FADD PMC6606851__F8 Pathway activity measured with luciferase reporters for canonical signaling (STF) WNT3A APC GSK3B ROR2 PMC3662247__F4 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity HMGB1 TBK1 TLR5 TLR9 IRF7 TRAF6 IRF3 MYD88 TLR1 TLR3 NBR1 TLR8 TLR7 TLR4 TREM1 AIM2 TIRAP CD24 PMC5521727__F1 Hsp90 and Physiological Stress Are Linked to Autonomous Transposon Mobility and Heritable Genetic Change in Nematodes TES POLN NR1C1 PMC12131761__F1 Analysis flowchart MIP MVP PMC7522761__F1 Interferon signaling from dermatomyositis skin analysis STAT2 IRF9 PIAS1 TYK2 IRF-1 PSMB8 IFNG BAX IFIT1 PMC1995599__F2 MOLECULAR AND CELLULAR MECHANISMS OF THE ANABOLIC EFFECT OF INTERMITTENT PTH BAD RUNX2 PTH SMURF1 PMC8257499__F5 Rare copy-number variants (CNVs) in spina bifida (SB) cases participate in SB-relevant pathways and affect various aspects of one-carbon metabolism BHMT2 OMG ALDH7A1 AVIL PMC12158998__F6 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation FHIT EGF RET BAD RASSF1 ERBB2 AK3 POLK CASP9 ENG PAH PMC7522761__F2 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis skin analysis RSAD2 STAT2 IRF7 IRF9 CXCL10 MYC IFNL1 IRF3 HEL60 STAT1 ISG15 OAS2 APOL6 IRF-1 STAT3 PMC12158998__F5 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation CASP3 RARB FHIT MAX CDK2 POLK CASP9 PTEN SKP2 PMC7522761__F5 Ingenuity pathway analysis of several candidate genes with oncogenic and tumor suppressing properties downstream of IFNG signaling NPM1 STAT2 IRF7 IRF8 IRF9 POSTN MYC CD44 TNF CDKN2A IFNG STAT1 IDO1 NFKBIA IRF-1 IL1B STAT3 PMC7522761__F4 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis muscle analysis ENO3 STAT2 MYC APOC2 CD44 MARK1 TFRC HLA-DRB1 HLA-C STAT1 HLA-A RELA STAT4 PANX1 STAT3 PMC6567055__F1 Tumor-associated macrophage (TAM) function in the ovarian cancer tumor microenvironment (TME) and examples of therapeutic strategies IL10 SIRPA CD47 CCL2 CCL18 CCL22 PMC8786484__F6 Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology CDA APP PMC11815730__F3 Hippo signaling pathway components in mammals YAP1 TEAD4 LATS1 LATS2 PMC3815562__F1 Outline of steps mediating androgen synthesis and metabolism in prostate cancer cells HSD3B1 AKR1C1 UGT2B17 AKR1C2 CYP17A1 STAR HSD17B6 PMC4490529__F7 Schematic model of DMF-induced neuroprotection in rat NPCs and differentiated neurons FTH1 NQO1 SRXN1 HEL-S-22 PMC5528384__F7 Cyclophosphamide (CTX)‐mediated immunomodulation on the basis of genes up‐regulated by treatment CARD9 BCL10 SRC SYK CXCL2 PMC3033602__F1 Adapted from KEGG colorectal cancer pathway [, , ] FOS SMAD2 APC CASP9 SMAD4 BAX PMC8485019__F1 Bile reflux and hypopharyngeal cancer IL10 EGFR BCL2L1 IL6 IL1B STAT3 PMC3662247__F6 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity CD14 HMGB1 TLR4 TRAF6 IRF3 MYD88 TIRAP PMC9600942__F5 Tumor-Infiltrating Dendritic Cells: Decisive Roles in Cancer Immunosurveillance, Immunoediting, and Tumor T Cell Tolerance IDO1 CCL2 CSF1 FOXP3 PMC11840835__F3 Diagram of mechanisms of glucose controlling the fate of blastocyst CDX2 YAP1 TFAP2C TEAD4 MTOR PMC7062300__F2 MS identification, quantification and analysis of protein meK modifications in human platelets MRPL32 POLR3A PPM1K MARCKS CAP1 PAXIP1 ZFC3H1 STAT1 ITK GIPC2 NUP85 EPPK1 RNPS1 TP53BP2 ME2 EEF2 LAMB2 EIF4G1 ADNP RAB10 CALM1 SPTBN4 PPP3R1 HEL-S-64p SCA7 HEL-S-100n IGF2R HEL-S-7a ANKRD11 PPFIA2 DOCK8 HEL-S-15 ANXA6 TLK2 EIF1AX SFRS8 EIF2S3 MRPL10 UBE2U SYNE1 HEL-S-108 ZNF148 SCAF11 TNS3 VPS41 PLGRKT CEP290 ALMS1 PDE3B HNRNPR ETFB SLC39A2 QRICH2 EEA1 SPTBN5 WASHC5 DBT TRIM25 CMSS1 LCK SMC2 SMG1 PPP2R5E KIF21A INF2 TRIM37 RPP40 PMC7407354__F1 Scheme of the amino acid (AA)-related energy metabolic pathway shows the amino acids and their metabolites in the nontumor and tumor regions PC PCK1 PCK2 GLS PMC4037996__F2 Role of normal and mutated KRAS protein in the regulation of the signalling pathway associated with EGFR activation EGF EGFR PMC4037996__F1 Intracellular signalling pathway originating at EGFR and inducing the activation of proliferation, inhibition of apoptosis, and differentiation of epithelial and cancer cells EGF FOS EGFR MYC MAPK1 PTEN MTOR TGFA JUN PMC2193492__F1 Pathways initiating transcription from pIV of the CIITA gene STAT1 MHC2TA USF1 PMC6105527__F2 Cut loose and run: The complex role of ADAM proteases during neural crest cell development ERBB2 ERBB3 MYC C6 CCND1 TFAP2A PMC7598701__F10 Differentially expressed genes involved in the p53 signaling pathway were annotated by KEGG AIFM2 SIAH1 PERP ATM CDK2 MYC MDM2 CASP9 PIGS PTEN ATR RFWD2 PMC5016207__F2 Factors involved in the ontogeny of fetal Leydig cells DHH KIT HGF IGF1 AMH SI SF1 AMHR2 TGFBR3 WT1 ARX GATA4 PMC7898445__F8 Signalling pathway of Eno-RPSA induced the loss of BBB integrity TLR4 EIF4E HSPD1 RPSA PMC9407997__F2 Genetic Variants Associated with Elevated Plasma Ceramides in Individuals with Metabolic Syndrome ASAH2 SGMS1 SMPD2 CERS3 SPTLC2 SPTLC3 CERS5 SGMS2 CERS2 PMC7917224__F8 Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload GSK3B GATA4 PMC5310224__F3 The unfolded protein response in immunity and inflammation TLR4 ATF4 GSK3B TRAF6 TNF IL1B PMC5856749__F5 NRF2-mediated oxidative stress response –signaling in the nucleus FTH1 FTL HEL-S-107 PROX1 UBB MAF AOX1 USP14 ATF4 GPX2 PPIB JUN CLPP PMC6858307__F1 MDC1 loss causes greater IR sensitivity than H2AX loss RNF168 RNF8 ATM MDC1 RAD50 H2AX PMC7775612__F2 Cell signaling pathways activated in acute inflammation induced by carbon nanotubes (CNTs) NLRP3 SYK IL1R1 IL1B PMC6650359__F6 Proposed pathway for the role of OLA1 in ANG II-induced cardiac hypertrophy NPPA GSK3B MYH7 PMC11677578__F11 Arachidonic acid metabolism pathway PC MAX HEL-S-25 DIO1 PTGES PTGES3 PMC3819050__F2 Wnt7a signals bi-directionally at vertebrate synapses WNT7A DVL1 PMC7232598__F4 Ingenuity Pathway Analysis (IPA) network diagram of differentially expressed genes in patient vs NOTCH2 UBLCP1 VPS50 TMEM126A CDKN3 S100A12 HEL-S-68p USP16 PAIP2 PPM1D HEL164 NEK2 FANCG PNP PMC9641390__F3 Targetable vulnerability of deregulated FOXM1/PLK1 signaling axis in diffuse large B cell lymphoma EEF2K PLK1 SOX2 FOXM1 NOTCH3 IGFBP5 HES1 RICTOR ATM CXCR4 MSH6 CCNB1 MDM2 IGFBP2 CDC2 MSH2 ATR AXL TTF1 TFAM PCNA STAT3 PMC4408853__F1 Neuronal Ca2+signalling toolkit ORAI1 STIM1 STIM2 PMC11677578__F10 Autophagy–animal pathway CTSL TSC2 MAX TP53INP2 INS PTEN MTOR HEL-S-130P PMC7716168__F6 The role of MOB1A in the survival of GBC cells under glucose-deprivation conditions IL6 MOB1A STAT3 PMC4069059__F7 Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells CASP3 RIPK1 CASP9 RIPK3 JUN MLKL PMC3928158__F1 Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells CD46 HEL-S-28 MYC CD74 NOD2 PMC8100412__F9 Integrated Molecular Docking with Network Pharmacology to Reveal the Molecular Mechanism of Simiao Powder in the Treatment of Acute Gouty Arthritis MAF TH TRADD SI TAL2 SF1 PMC7070171__F8 Schema showing the major roles of butyrate in inhibiting atherosclerosis of mice in this study PREB SLC2A4 ABCG1 PLIN5 ADFP GCK VNN1 SP1 CYP7A1 PMC5227296__F4 Cordycepin function in chondrogenesis and chondrocyte hypertrophy of MSCs NOTCH2 GIG8 NOTCH1 PMC3064890__F5 BRCA2/RAD51 pathway in the response to stalled forks ATM BRCA2 ATRIP EMSY ATR PCNA PMC3064890__F4 BRCA2/RAD51 pathway in response to DSBs HP ATM BRCA2 ATRIP EMSY ATR PMC3540089__F1 PORPHOBILINOGEN DEAMINASE Deficiency Alters Vegetative and Reproductive Development and Causes Lesions in Arabidopsis UROD UROS CPO PMC7068849__F4 Regulation/function of IL-17 secreting cells during candidiasis CARD9 APC IL1B PMC3412625__F6 Combination therapy with VELCADE and tPA is neuroprotective in aged rats after stroke and targets miRNA-146a and the toll-like receptor signaling pathway TLR4 IRAK1 MMP9 PMC8316858__F8 Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation CASP3 BAD CASP9 BAX PMC4249809__F1 Role of TGF-beta in healthy and OA cartilage SMAD2 TGFBR2 SMAD1 DKFZp781O1323 SOX9 PMC6719163__F6 Nobiletin-induced apoptotic pathway in bladder cancer cells BAD ATF4 EIF2A HEL-S-99n MTOR BAX PMC4040287__F4 SIRT1 in neurodevelopment and brain senescence RARB ROCK1 ADAM10 BDNF HSF1 SIRT1 PMC9138898__F1 Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity CASP3 CASP9 CASP8 BAX PMC4974939__F3 Activation of “RNA-sensing” TLRs on neurons and microglia triggers distinct effects IL16 TLR7 TNF TLR3 PMC7150781__F3 HBV suppression of type I interferon (IFN) response (Green arrows indicate the related signaling pathways and T-arrows in red indicate blocking the targets) TBK1 OAS1 STAT2 IRF9 IRF3 TLR3 MAVS PMC7868824__F8 Overall, pyrazole significantly up-regulate E-cadherin expression and regulated MMP-2 expression in A549 cells TLR4 EGFR PMC6523735__F6 Proposed model for miR-130a downregulation of HCV infection ATG12 PKLR DKFZp686F0183 PMC10308132__F1 Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies CGAS CCNA2 IRF7 TRAF6 IRF3 PMC11799893__F3 Transcriptome analysis of isopentanol synthesis pathways PDC F2 MPC1 MPC2 PMC5599481__F4 Overview of arachidonic acid cascade associated with inflammatory pain response LTA COX1 LTB PMC5842623__F1 Mammalian target of rapamycin (mTOR) signaling pathway FLCN CHUK BRAF PRR5 GSK3B NRAS AKT1S1 PTEN MTOR RPTOR PDPK1 INSR LPIN1 RPS6 EIF4B SGK1 NPRL2 RNF152 ARHA EIF4E CAB39 TNF DEPTOR IRS1 DDIT4 RHEB MLST8 IKBKB TTI1 RICTOR IGF1 GRB2 STK11 SLC3A2 GRB10 SKP2 PMC5684300__F2 Simplified diagram depicting canonical and non canonical Beta-catenin signalling pathways in bone RUNX2 APC PTH ROR2 PMC2852112__F2 Anti-viral and pro-viral functions of autophagy TLR7 ATG12 EIF2A DKFZp686F0183 PMC2852112__F1 Scheme of the autophagy pathway ATG12 ATG3 ATG10 MTOR ATG14 DKFZp686F0183 PMC7701249__F2 Iron metabolism-related pathway in ferroptosis TF PMC9059101__F11 Critical and Diverse Roles of CD4–CD8– Double Negative T Cells in Nonalcoholic Fatty Liver Disease IL17A CD36 PMC5778882__F1 The Axl signaling pathway GRB2 SRC ELMO2 AXL STAT3 PMC11599216__F4 Crossroads of epigenetics and immune pathways KDM5B METTL3 KDM5C TRAF6 IRF3 MYD88 EZH2 PHF2 TET2 PMC5333072__F1 MNT and its place in the MAX-MLX network of interacting proteins MLXIP MXD1 MXD4 MNT MAX MYCL MYC MLX MXD3 MGA PMC5495965__F2 Predicted interactions among proteins encoded by genes expressed differentially in late proestrus SORT1 TH EPHA3 GHSR OPRM1 PGR SLC32A1 NTS CNR1 UCP2 SLC17A6 ADORA2A CCK AVPR1A ABAT SLC18A2 KISS1 GRIA4 GAL PMC4698356__F2 Proteins highlighted for their contributions to molecular regulation in diabetes and heart failure OGA SP1 STIM1 PMC3345192__F1A MYC on the Path to Cancer MAX GSK3B MYC PMC7850464__F1 B7-H1/PD-1 signaling pathway in osteosarcoma APC PTEN STAT3 PMC2916838__F8 NPRL2 Sensitizes Human Non-Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway NPRL2 ATM PMC7035145__F13 Schematic showing integration of inputs in the SIP syncytium PDGFRA VIP PMC8224368__F2 Combined Single Nucleotide Variants of ORAI1 and BLK in a Child with Refractory Kawasaki Disease CASP3 ITPKC FCGR2A CD40 SYK BLK PMC8998982__F2 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response SLC1A4 PFAS PLK1 EGFR MYC CDK12 SAE1 HEL-S-87p AURKA AURKB SLC25A6 PES1 MAX ATF4 SLC3A2 MCL1 CAD ATR CDK9 HK2 BRD4 PMC8998982__F1 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response MYC MCM7 WRN CDC45 CDK6 CCND2 MCM3 MCM5 MCM6 POLE MCM2 CDC6 CDK2 CDK4 CDT1 PCNA PMC5006314__F7 Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFBeta-p38MAPK pathway NBL1 CCND1 CDK4 PMC3170700__F1 Activation of cellular responses during ER stress ATF4 EIF2A SELL PMC6770886__F2 Rac3-mediated mechanisms in cancer SHD RAC3 ARF6 VAV2 PMC7074533__F3 The vascular smooth muscle contraction pathway PRKCE ROCK1 GUCY1A2 PLA2G2E ACTA2 MAPK3 KCNMA1 RAMP3 PRKCA CACNA1S ARAF ADM CALD1 RAMP2 ROCK2 PTGIR NPPA CALCA NPR2 ACTG2 NPPB CALML4 NPPC PRKG1 MAP2K2 ARHA CALM1 GNA11 PLCB4 ADORA2A EDN1 EDNRA MYLK2 PLA2G1B AVP ADRA1A GNAS RAF1 MYLK ADCY9 PMC5520734__F7 Schematic diagram of G0/G1 phase arrest and ROS-dependent MAPKs pathway in which furanodienone induces cell growth inhibition and cell death in CRC cells CASP9 CCND1 CDK4 CASP8 CDK6 BAX PMC6211194__F2 Simplified metabolic pathway of ∆9-tetrahydrocannabinol (THC), or ∆1-tetrahydrocannabinol, under the monoterpenoid naming system, in humans UGT1A3 UGT1A9 CYP2C9 CYP3A4 UGT1A10 UGT1A1 PMC5549626__F2 PLCG1 deficiency perturbs phosphorylation on canonical TCR signaling proteins PLCG1 ITK BCL10 FOS LCK VAV1 PLCG2 REL JUN LAT CDC42 CD36 PMC5587804__F4 Differential metaMIR analysis recovers miRNAs involved in cancer BMP2 SMAD2 TGFBR1 TGFBR2 MYC SMAD4 BMP7 PTEN CHD5 BMP4 NF1 NOG FOXD3 BMPR2 BMPR1A NF2 TGFBR3 SMAD1 TGFB1 PMC6049516__F1 Altered Hippo pathway signaling contributes to the kidney cystogenesis in Pkd1 mutant ADPKD ARHA PKD1 PMC9580211__F8 CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK HEL-S-66 RHO RAC1 PMC8511707__F1 Fatty Acids Derivatives From Eukaryotic Microalgae, Pathways and Potential Applications DES HEL-S-5 PMC4788885__F5 Wnt signaling pathway ROCK2 NLK DAAM1 SIAH1 APC CER1 SMAD4 SKP1 ARHA RBX1 PMC11512478__F8 Mechanism of CHRDL1-MED29-mediated interruption of EMT evolution in OSCC IXL UNK CDH2 CHRDL1 PMC4144918__F1 Do Mantle Cell Lymphomas have an “Achilles Heel”? DKFZp781B1423 RELB TRAF3 MTOR CDK6 BTK BCR ATM LYN MDM2 BCL2 CD40 SYK CDK4 MCL1 TRAF2 BAX PMC3843232__F1 Causal role for JAK2 V617F in thrombosis TPO MPL PMC6611921__F4 Pathway map based on renal age-associated gene (RAAGs).Enriched molecular pathways based on the set of 634 RAAGs are displayed HEL-S-62p EGF CFB CXCL6 TNFRSF11B TNF MTOR PMC6073901__F2 Proposed model for a signaling network between Notch, HIF-1A, and GPER in cancer epithelial-mesenchymal-transition (EMT) NOTCH1 PMC8924146__F4 MicroRNAs as a clue to overcome breast cancer treatment resistance EREG IGF1R ERG EGFR PTEN MTOR PMC3979163__F1 The canonical Wnt signaling pathway APC GSK3B RHO PMC8093869__F1 Neuroinflammation in HIV-Related Neuropathic Pain CASP3 PC CX3CR1 CXCR4 FZD2 ROR2 PMC4424147__F1 Receptor-mediated activation of PI3K-Akt pathway and signaling BAD TSC1 PHLPP2 BCR FOXO3A LYN GSK3B SYK PTEN MTOR RHEB BAX PMC6325856__F10 The proposed cardioprotective mechanism of mAb A treatment in hearts following a myocardial infarction KLF15 GSK3B MTOR PMC6692500__F5 Sodium and potassium loci in behavior, thermoregulation, and weight loss networks FGF21 PLCL1 ADRA2C NEGR1 LRRN2 TMEM107 BRINP1 CHST10 NRXN3 CYP2A6 HTR4 RARB SCN2A AHR PPP3R1 MLXIPL PKHD1 FNDC4 BDNF HEL-S-117 PMC9616118__F9 Meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy BAMBI SHH SMO MYD88 PMC3520542__F13 Molecular mechanism for Elovl5 control of mTORC2, FoxO1-S256 phosphorylation, and hepatic GNG RICTOR FADS2 PCK1 ELOVL5 FADS1 ELOVL6 ELOVL2 FASN PMC7905058__F3 Gain-of-function of mutant p53 over proliferation, invasion and metastasis SENP1 DAB2IP RAC1 PMC5977062__F1 Diverse regulatory mechanisms of ncRNAs on Wnt signaling pathway APC LRP5 LRP6 PMC5542021__F1 Signaling pathways for selected transcripts that regulate dendritic spine density PAK1 CDC42EP4 CDC42EP3 HEL-S-47e ARHA CDH2 CDC42 PMC406534__F1 Proteolytic processing of APP is divided into an amyloidogenic and an antiamyloidogenic pathway BACE1 APP ADAM10 PMC9563036__F3 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health IQGAP1 RAC1 PMC9563036__F4 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health NGF BCL2 BDNF BAX PMC7351826__F7 Hypothesis that Sal B protects myocardium through inhibiting the expression of HMGB1 via activating PI3k/Akt signalling pathway in myocardial I/R injury HMGB1 TLR4 BAX PMC11635239__F8 LPS induces the upregulation of activin-A in recAMs, which can drive the EMT process by activating the TGF-Beta-SMAD signaling axis SMAD2 INHBA PMC3275780__F2 T cell activation APC ZAP70 SRC PMC6319725__F10 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells NAMPT CSA2 PMC10905894__F4 Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation CASP6 CASP12 ATM CASP9 CASP2 CAD TNF DIABLO TRAF2 HTRA2 FADD HRK PMC7849651__F6 Summary of the potential pathways about exogenous antigen 11S processing and presentation in the distal intestine TSC2 CDA AIP RHO MTOR RHEB AEBP2 PMC9563451__F2 Colorectal Cancer and Purinergic Signalling: An Overview ADA PANX1 PMC7071425__F9 Elav1 pathway for mRNA stabilization PRKCA SET NUP214 HEL-S-93 PMC3246369__F2 Small RNAs in transcriptional gene silencing and genome defence AGO1 CHP2 CHP1 ARC PMC5739664__F7 Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling CORT TBK1 IRF3 MAVS PMC8431321__F2 Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors TBK1 SIRPA TLR7 TLR4 TMEM134 IRF3 MYD88 TLR3 MAVS PMC12015515__F1 Novel signaling pathway linking IL18 proteolytic processing to anticancer immunity STAT1 CASP3 ISG15 CDK8 IL18R1 PMC9052234__F2 Cytokines in Abdominal Aortic Aneurysm: Master Regulators With Clinical Application CCR5 CCR2 IL13 PDGFA CXCL10 CXCR4 TGFBR1 IL33 TGFBR2 IL8RB IL6R IL1B PMC8358715__F2 Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases AHR STAT4 FOXP3 PMC3417165__F1 PI3K/AKT signaling pathway in Tregs TSC2 TSC1 PTEN RHEB FOXP3 PMC8875876__F4 Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression TPH1 KYNU KMO TPH2 PMC8124456__F1 CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology DPP4 CXCR4 CXCL12 MTOR PMC3215886__F2 The “inhibitory” pathway of WNK4 WNK3 WNK1 WNK4 PMC7313089__F2 Involvement of ubiquitin in the key signaling pathways important for IFN production and IFN responses TBK1 CGAS TANK IRF3 CGA MAVS PMC6510543__F1 A sugar rush for innate immunity TIFA TRAF6 ALPK1 PMC8746116__F6 Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic A‐ and B‐cells GCLM GSTA4 CYP2R1 KEAP1 SQSTM1 GCLC NFE2L2 GSTM3 NQO1 PMC3104579__F1 RhoA/ROCK I pathway and remodeling of microtubule network underlie the polarization and migration of HSPCs ICAM3 CXCR4 MSC CD34 CD44 ARHA PMC195990__F5 A model of Hip1's role in lung branching morphogenesis FGF10 SHH PMC12234736__F5 LLPS regulates immune cell alterations during adaptive immunity BCR GRB2 LAT PMC12234736__F4 Phase separation is associated with cGAS-related inflammation TBK1 CGAS IRF7 TREX1 IRF3 TRIM25 MAVS PMC12234736__F3 Sufu prevents sepsis by disrupting the LLPS of TRAF6 TLR4 IRAK1 SUFU TRAF6 IRAK4 MYD88 PMC9573972__F1 Unraveling the mechanobiology of cornea: From bench side to the clinic MYC RHO ABCG2 SOX9 TGFBI BMP4 PMC4480706__F8 HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation CDK2 EGFR PMC6107301__F8 The conversion of a T:G mispair to a T:A mutation by guanine oxidation followed by long-patch base excision repair APC MPG PMC2890409__F1 Classification of Dengue Fever Patients Based on Gene Expression Data Using Support Vector Machines TLR7 TLR9 IRF7 RIGI IRF3 MYD88 TLR3 PMC4551447__F1 Decade in Review-Kidney Cancer Kidney cancer's decade—discoveries, therapies and opportunities TSC2 SMARCA4 VHL PTEN SETD2 BAP1 PMC3653146__F1 Possible signal pathway activated by cathelicidin (LL-37) to inhibit cell proliferation in gastric cancer cells CDK2 SMAD1 DKFZp781O1323 CCNE2 PMC7393681__F2 More RAS vulnerabilities, downstream MYC MTOR CDK9 PMC8709003__F3 Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation COX1 MYD88 PMC11174838__F3 Resistance Exercise and Essential Amino Acid Intake on Muscle Quality, Myokine, and Inflammation Factors in Young Adult Males TNF MTOR PMC11763651__F1 Biosynthesis of BH4 and genetic diseases due to BH4 deficiency TH DHFR PMC3618895__F4 Significantly changing expression sub-networks in LMB hypothalamus TH GNRHR NR3A2 AMACR FOS PVALB SENP1 HOMER1 PROC DRD1 KLKB1 DRD2 GAD1 PRL NFKBIA POMC EP300 SLC12A2 NPY SYT7 GH1 PCK2 TGFB1 PMC4152244__F1 Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma TSC2 TSC1 VEGFA STK11 BNIP3 HIF1A MTOR PMC4575550__F1 Effects of exercise on the signalling pathways associated with muscle growth and wasting in sarcopenia and cachexia IGF1 SMAD2 MTOR PMC5841108__F11 Schematic representation of miR-34a regulating SIRT1/AMPKA signaling pathways and Egr1 involved in the HG-induced fibrosis and inflammation in RMCs EGR1 CXCL5 SIRT1 PMC12152632__F11 Proposed mechanism of TX's neuroprotection against Mn toxicity by upregulating REST expression via Wnt/Beta-catenin signaling in CAD neurons WNT3A LRP5 LRP6 REST GPER PMC3621754__F3 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches EGFR GRB2 FGFR3 SRC MTOR PMC4008387__F2 Molecular mechanisms of hepcidin regulation BMP6 EPO HAMP GDF15 SMAD4 TMPRSS6 FURIN SMAD1 DKFZp781O1323 TFR2 STAT3 PMC4278318__F1 NMI and EMT STAT1 NMI JAK1 PMC3621754__F6 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches MUC1 STAT1 TRADD RELA TRAF2 STAT3 PMC3621754__F5 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches EGFR CCND1 SRC TCF7L2 PMC8143046__F2 Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells ECE1 SNX27 SNX1 APPL1 PMC5881178__F4 Metabolomic differences associated with Wnt1-initiated tumors CDO1 WNT1 PMC8911130__F1 An Assessment of Selected Molecular and Biochemical Markers of the Folate Pathway as Potential Risk Factors for Fetal Trisomy 21 during the First Trimester of Pregnancy in the Polish Population MTR MTRR TYMS PMC7923226__F2 Main molecular mechanism of actions deployed by the anticancer peptides presented in this review CASP3 CASP9 FADD BAX PMC8046990__F9 NAD+-SIRT1 signaling fine-tunes the activity of key transcription factor networks to promote adipocyte function CXCL1 CXCL10 IL1RN LCN2 LAMA4 MMP3 NMNAT1 NDUFB8 NDUFA3 NMNAT2 NDUFB3 GSTA3 COL6A1 LAMC1 NDUFB6 SIRT1 NDUFB5 PMC3494243__F2 Pathways for C18 PUFA conversion to C20–22 PUFA synthesis FADS2 ELOVL5 FADS1 PMC3680926__F1 Estrogen receptor functional domains and signal transduction schemes TF PMC3008616__F1 EGFR pathway and its main downstream effectors (top) BRAF EGFR PTEN PMC9250793__F1 Signaling pathways in hair follicle stem cells APC LRP5 LRP6 PMC5535855__F3 Schematic diagram showing the pathological cardiac functions of ANKRD1 in relation to hypertrophy, fibrosis and apoptosis ANKRD1 NOTCH4 KIF6 NCL PLG IGFBP6 LOXL1 SCX GATA4 BAX PMC7396149__F4 Immunosuppressive drugs for corneal transplantation and their sites of action in the immune system CS APC CD40 CD80 CTLA4 MTOR PMC9250793__F4 Signaling pathways in hair follicle stem cells SUFU GLI3 SMO PMC7769953__F1 IL-6 signaling pathway and inhibitory agents SRC IL6 STAT3 PMC5628484__F6 Regulatory roles of differentially expressed genes involved in the MAPK signaling pathway (a, map04010) and pathways in cancer (b, map05200) MOS FLNA EGFR PIR TRAF6 TNF POLE MAX GRB2 JUND ECSIT RAF1 TRAF2 PMC11048686__F1 Vitamin D synthesis pathway CYP27A1 NR1i1 CYP2R1 DBP CYP24A1 CYP27B1 PMC4383680__F10 G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons POMC NPY AgRP MC4R PMC6314014__F2 Top network of metastasis virulence biomarkers (Ingenuity Pathway Analysis Knowledge Base) SPSB1 NAMPT CTSK CX3CR1 AEBP1 PCOLCE FSTL1 SCARF2 FCGRT HMFT1766 NID1 HSPG2 TIMP1 GJA1 NRP1 LOXL1 PMC6314014__F1 Top network depicting the influence of high fat diet on mammary tumor gene expression (Ingenuity Pathway Analysis Knowledge Base) GATA6 PTEN TNF EIF4G1 CASP3 EIF3E HBA2 MAPK13 PABPC1 AGER FGF10 MAPKAPK5 HBB SPHK1 DDX5 GATA5 PRKDC HEL-S-133P SAA2 COL4A2 PMC5350105__F1 M1 macrophage metabolism ME1 CIC AASS ACLY CAD HEL-S-133P PMC11484340__F3 Cross-inhibition between the PI3K/AKT/mTOR and RAF/MEK/ERK pathways TSC2 BAD TSC1 MDM2 PTEN PMC3751038__F2 T-cell death during HIV-1 infection CXCR4 FADD BAX PMC6523474__F2 Acute phase response (APR) is central to the FL induced response in skin, brain, and liver of all three model organisms HMGB1 NGF HAMP HEL-S-28 TEC MTOR POR CNTF HEL111 TREM1 HP CXCR4 ECSIT FLT3 OSM PMC7981903__F3 Role of GRP78 in cellular apoptosis ATF4 EIF2A TRAF2 PMC3408740__F1 Alarmins: awaiting a clinical response HMGB1 S100A8 S100A9 IL1B PMC3700945__F5 Pathway detail for the IPN: Mucus Hypersecretion model.Notes: The Mucus Hypersecretion model contains signaling detail from four main pathways known to induce airway MUC5AC production IL13 SP1 TNF PMC4458296__F1 Purine metabolic pathway ADA AMPD1 XDH ASL PNP PMC4199871__F2 WNT Signaling in Bone Development and Homeostasis APC SOST LRP5 LRP6 DKK1 WIF1 PMC5310224__F5 Unfolded protein response in immunity and inflammation NLRP3 ATF4 TXNIP ATF5 TNF XBP1 IL1B PMC7266379__F1 Loss of MAP3K7 sensitizes prostate cancer cells to CDK1/2 inhibition and DNA damage by disrupting homologous recombination FDX1 PLK1 F8 BIRC5 SHMT1 MYC CPT2 PSMB3 DHPS MTTP PSMD13 HINT1 POLE2 POLE4 POLE ATP2C1 A2M POLA2 PSMC6 POLE3 IMPDH1 HDAC2 RAD51 TUBB PSMC3IP MAP3K7 CENPE PPIF AURKB MLST8 VAMP2 TPP2 CDK2 DHFR HABP2 PNP PIG59 IKBKE CHUK SEPSECS PSMD9 TOP2A CRYZ KIF11 CHEK2 RRM1 RRM2 APP CDK4 HEL-S-70p CDC2 CTH SLC25A5 MTFMT MTHFD1 CHEK1 NR1C1 HDAC1 AURKA SLC25A6 PSMB6 SMPD4 SIRT7 RPS6KB1 PSMD12 CPT1A TUBG1 PARP2 TUBD1 TYMS HEL-S-51e DHODH PSENEN PSME2 PMC4265444__F5 The sulfur assimilation pathway and the genes encoding the enzymes of the different biosynthetic steps MT3 GPX2 GPX1 PMC8918735__F8 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia BAD GEM PMC6324535__F7 Working model CDK4 CDK6 PMC8918735__F7 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia BAD GEM PMC4422099__F2 Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms MCC TRAF3 PARP1 PHB2 PMC8918735__F4 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia TH HIRA ATM HPD APP POR ACD PMC8918735__F3 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia KL SELE PMC2586109__F1 Protein kinase C isozymes as therapeutic targets for treatment of human cancers APC GSK3B RAC1 PMC9091963__F1 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System COX2 ATR PMC5536362__F8 G protein-coupled receptor kinase 2 promotes cardiac hypertrophy GSK3B ADRBK1 PMC3578734__F1 Scheme of CML hematopoietic stem cell signaling pathways in which predicted targets of microRNAs associated with CML are involved BAD GAB2 TGFBR1 MYC MDM2 GRB2 SMAD4 CBL PMC5458280__F3 Carboplatin-induced hematotoxicity among patients with non-small cell lung cancer: Analysis on clinical adverse events and drug-gene interactions EPOR CD14 SRI CD9 CD37 EPO CD33 CD34 CD44 TPO TNF CD59 IL3 CD2 CD7 CD22 ELL CD19 CD36 CD24 PMC3539548__F1 Host cell machinery gets activated during influenza infection and leads to trigger Signaling pathways F2 ATF2 EIF2A PMC9091963__F8 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System COX2 PMC4829957__F3 Targeting EPO and EPO RECEPTOR PATHWAYS in Anemia and Dysregulated Erythropoiesis ERFE EPOR EPO PTPN11 PTPN6 PTPN18 PMC9091963__F9 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System NR1i1 SELL PMC4327877__F8 TGF-Alpha-IL-1A/Beta-IL-1ra autocrine cascade contributes to TNF-induced hepatocyte proliferation and Adv-infection sensitized apoptosis through the regulation of multiple shared signaling pathways EGFR TNF TGFA PMC7835526__F3 Interplay of IGF-1R-related signaling and niche microenvironment in stemness expressions of different cell types IGF1R HRG SOX2 IGF2 CCL5 MTOR IL6R IGF1 ERBB2 CXCR4 MSC GSC HEL-S-70p PMC4588066__F1 Regulation of oocyte maturation MOS WEE1 APC CDC2 GPR3 MYT1 PMC10985098__F3 Skeletal interoception in the aberrant subchondral bone remodeling of OA NPY AgRP MSC ARC PMC3021995__F3 Post-transcriptional control of mammalian clock genes CRY1 HNRNPD PER2 PMC8151534__F7 Evidence of Cooperation between Hippo Pathway and RAS Mutation in Thyroid Carcinomas AFP HIPK2 GHB2 SOX2 AREG BIRC5 APC GSK3B MYC SMAD4 LATS1 RASSF4 ID1 LATS2 NKD1 BIRC2 PAK1 GIG8 NF2 CCND1 RASSF6 PMC2680597__F1 Methylobacterium Genome Sequences: A Reference Blueprint to Investigate Microbial Metabolism of C1 Compounds from Natural and Industrial Sources HEL-S-62p GCK PCCA PCCB HPR PMC9106463__F3 PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function BCL2 BAX PMC8336005__F4 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions SFRP4 FZD3 RUNX2 LRP5 LRP6 PORCN FZD4 FZD1 NKD2 PYGO1 SFRP5 SOX9 NKD1 PYGO2 MYF5 FZD2 SFRP1 SOX5 SOX6 WLS FZD8 PMC8336005__F3 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions APC GSK3B LRP5 LRP6 COIL PMC8155968__F2 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities IL7R CCND1 PTEN MTOR PMC8155968__F1 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities ATM BCL2 MTOR ATR BAX PMC9666367__F2 Cellular phenotypic transitions in diabetic nephropathy: An update FGFR1 LRP5 LRP6 ARHA SMO PMC12084448__F4 Metabolomics study in NENs ACVR2B ACVR2A SMAD2 SMAD4 INHBA FOXA2 PMC7882971__F6 LETM1 down‐regulation‐induced autophagy in CRC cells LETM1 MTOR PMC4867331__F3 Notch and Wnt pathway inhibition by natural products MAML1 APC MYC CD44 PMC8226851__F4 SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants TLR7 IRF7 IRF9 IRF3 ACE2 TLR3 PMC12084448__F2 Lipid metabolism changes in NENs CYP46A1 HMGCS1 FABP5 ALKBH5 MTOR IGF2BP2 FASN PMC12084448__F1 Metabolic pathways in NENs ACSS2 ACLY MTOR TG FASN CD36 PMC3111669__F2 BMP signaling and its blocking SMAD6 SMAD4 SMAD1 DKFZp781O1323 PMC6536572__F3 Nrf2/ARE pathway during basal and stressed conditions GSK3B RBX1 NQO1 PMC3750636__F1 USP1 Domain structure and summary of the cellular functions of the USP1/UAF1 complex FANCD2 APC RAD18 PCNA USP1 PMC7640403__F4 Amino acid, energy and Wnt signaling to mTORC1 FLCN SLC38A9 CASTOR2 GSK3B CASTOR1 ENG HIF1A MTOR DEPTOR RHEB MLST8 TSC2 TSC1 FNIP2 PMC9376771__F1 Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment TLR4 IRAK1 TRAF6 IRAK4 MYD88 TAB3 PMC7281579__F1 Increased glucose metabolism facilitates endometrial cancer phenotypes POLE OGT PTEN JAK1 ACLY MTOR HEL-S-133P FOXO1 HK2 FASN STAT3 PMC2715501__F1 Study background HSD11B2 CYP11A1 HSD17B1 HSD17B2 HSD17B3 CYP11B2 PMC7489527__F6 Anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray IL16 IL4 IFNG PMC4747705__F6 BRAF(V600E)-directed recruitment of MAFG and its corepressors to CIMP and HIM gene promoters CHD8 DNMT3B BACH1 MAFG PMC3618314__F7 Characterization of CP genes in relation to the canonical TGFB signaling pathway C9 NODAL PMC6614686__F5 Pathway Map of Glioblastoma obtained from Wikipathways using Cytoscape PLCG1 FOXO4 PRKCZ IGF1R BRAF MAP2K4 EGFR PLCG2 PTEN LPA RB1 MAP2K3 FGFR2 CDK6 CCND2 NF1 BTK ATM SRC CCND1 ARAF PRKCI PDGFRA CDKN1B MAP2K5 IRS1 BRCA1 FOXO1 SPRY2 CBL TSC2 TSC1 EP300 PRKCB CDKN1A CDKN2B ERBB2 CDK2 GRB2 PRKCH PMC6928836__F1 A schematic illustration of unfolded protein response (UPR) and the effects of salicylic acid (SA) under stress condition in plants CS SAG PMC6563011__F2 Schematic view of PKCA inhibitory activity on the Wnt/Beta-catenin signaling pathway in the normal colon epithelium and in colon cancer PC APC FAP GSK3B PMC3192911__F2 Therapeutic tol-DC in organ allotransplantationTol DC can be either recipient- or donor-derived (in the case of living-donor transplantation) HLA-G APC FOXP3 PMC7719100__F2 Molecular mechanism of adipogenesis SMAD1 BMP4 PMC8336005__F5 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions ZNRF3 RSPO3 APC GSK3B LRP5 LRP6 TCF7L2 SFRP5 PMC8267940__F4 Instruction of Immunometabolism by Adipose Tissue: Implications for Cancer Progression MTOR ARG1 PMC6196292__F4 The proposed mechanisms of NEAT1 action in cancer EGFR EZH2 STAT3 PMC8801219__F8 Ecballium elaterium attenuates neuroinflammation in an animal model of Alzheimer’s disease through modulation of nuclear factor KB pathway TRADD MYD88 TNF IL1B PMC7589120__F1 Pathway connecting lipid synthesis, lysosomes dysfunction and iron accumulation in NBIA syndromes PLA2G6 FTL WDR45 C19orf12 COASY PANK2 CP DCAF17 PMC6832112__F1 RTK and nRTK networks in H MMP2 MMP9 EGFR GRB2 ADAM10 STAT3 PMC9385341__F2 From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease GPX4 LPCAT3 SLC3A2 PMC11466420__F8 Graphical overview of the effect of BA treatment on porcine oocyte maturation KEAP1 GPX1 HEL-S-44 PMC5609982__F10 Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death CCNB1 BAX PMC4051344__F1A Regulation of Inflammation in Cancer by Eicosanoids LTA COX1 LTB PMC3132189__F4 Proposed lipid metabolic pathways in Giardia PC PGP PALM PMC4169646__F7 Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1 BCL2 BNIP3 BAX PMC3190890__F7 The signaling pathway of EpCAM complex proteins in the regulation and enhancement of OSKM-mediated pluripotency reprogramming SOX2 EPCAM PSEN2 CLDN7 ADAM17 PMC4356243__F5 Advances in therapeutic development for spinal muscular atrophy EGF EGFR GRB2 BDNF SMN1 PMC4673535__F4 Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis CXCL16 CXCL9 AQP8 ABCG2 PMC4825819__F5 Coordinating muscle-specific gene expression with cell cycle exit CDK2 GDA CDK4 CDK6 PMC9448575__F3 Crosstalk between Oxidative Stress and Exosomes EGFR PMC3375988__F7 Schematic representation of the proposed roles of oleosin PC LPA PMC5410396__F2 Promiscuity of PLP enzymes involved in H2S synthesis PMC9202199__F9 Power of heteronemin in cancers BAD CCND1 PTEN MTOR STAT3 PMC9202199__F8 Power of heteronemin in cancers BCL2 STAT3 BAX PMC9202199__F6 Power of heteronemin in cancers CCND1 FADD PCNA PMC4532404__F7 Signaling pathway of focal adhesion VASP BAD FYN HEL-S-28 SHE ARHA PTEN CRK PMC7166610__F2 Illustration of virus activation of IFN‐I synthesis and its inhibition by the MERS‐CoV M, 4a, 4b and PLP proteins ISG15 TANK TRAF3 IRF3 PMC9149322__F8 Illustration of the mechanism of EEZS-induced apoptosis in human bladder cancer T24 cells BCL2 BAX PMC4532404__F8 Signaling pathway of regulation of actin cytoskeleton F2 APC INS ABI2 DOCK1 RHO HEL114 GAL PXN PMC3825194__F1 TGFB signaling through Smad-dependent and Smad-independent pathways SMAD2 SMAD6 SMAD4 TRAF6 RHO TF PMC3825194__F4 TGFB signaling pathway inhibitors under development for potential cancer therapy SMAD2 SMAD4 TF PMC5956756__F7 Proposed mechanistic scheme: miR-29c suppresses breast cancer by the TIMP3/STAT1/FOXO1 pathway STAT1 TIMP3 FOXO1 PMC9579409__F5 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens INA KL CS AGA APP PMC8417882__F5 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges ATF4 EIF2A ATF3 PMC5344005__F1 Molecular functions of long non-coding RNAs (lncRNAs) at different stages of prostate cancer, from prostate adenocarcinoma (A) to ongoing castration resistance (B) to a castration-resistant state (C) TH CKS2 PC ZNF217 SFN ERG MDM2 EZH2 PRUNE2 PMC8417882__F4 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges BAD PTEN EIF4E MTOR RHEB PMC4573218__F3 Some of the proposed signaling pathways activated by NK-R SHE SRC RHO PMC6770188__F5 Our model of the BRAF mutation positive mitogen-activated protein kinase (MAPK) pathway signaling mechanisms NF1 GRB2 SOS1 PMC6088794__F1 Androgen receptor signaling axis and potential androgen-dependent and independent mechanisms of disease progression MDM2 PTEN MTOR PMC8417882__F2 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges MEI1 DIABLO FADD PMC9579409__F3 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens TH BAD KIN PMC3314616__F2 Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens SOCS3 RASD1 PCK1 AGTR1 CEBPB IFNG FST EPHB1 PLAT IL18 A2M NGFR GBP2 BIRC3 TNFSF12 NCOA1 GCHFR NOS2 SP1 NR1H3 NCAN JUN HEL-S-133P GADD45G RGS4 FOS PTH IL6 TNF NR1C1 NFKBIA CREBBP HOMER2 CRH GH1 PMC4081601__F3 Proposed mechanisms of anticancer activity of digoxin EGFR SRC PMC10252649__F1 mTOR Signaling Pathway in Bone Diseases Associated with Hyperglycemia TSC2 ULK1 TSC1 TFEB GRB10 DEPTOR FOXO1 RHEB PMC9311581__F3 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress ME1 HEL-S-30 PHGDH HEL-S-162eP GOT2 PSAT1 HEL-S-51e OGDH SIAH2 HEL107 RPE HEL-S-133P HK2 CD36 PMC7696540__F4 Downstream signaling of EGFR and other receptor tyrosine kinases [,,] EGFR FLT3 MTOR PMC9311581__F2 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress EGF DPP3 KEAP1 RELA RELB PAQR4 TNPO1 PTEN TNF BRCA1 PMC11035635__F2 Core molecular mechanisms of different types of RCD and the potential CAF-derived molecules that regulate RCD HMGB1 ULK1 GPX4 IL18 HGF AMBRA1 ATG101 CXCL12 MTOR DHODH ATG14 GSDMD PMC9503143__SF1 H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish KEAP1 HEL-S-44 NQO1 HEL-S-22 PMC12122316__F4 LncRNAs play a ceRNA regulatory role in RA (by Figdraw) CASP3 TLR4 ADAMTS9 SIRT6 CASP9 YY1 TSPEAR PDK4 COL5A2 BAX PMC10138803__F7 MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells CD14 IL1A IRAK1 TRAF6 IRAK4 IL6 MYD88 MTR TLR4 RELA JAK1 IL1B STAT3 PMC9570224__F5 Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels PC PLD2 RPE PMC12122316__F3 Major apoptosis signaling pathways participate in RA (by Figdraw) BAD TRADD RAC1 TNF HTRA2 NLK CASP3 ATM CYLD CASP9 ATR TRAF2 JUN BCL9 FADD PMC5826678__F2 Three basic mechanisms of aberrant activation of Hedgehog signaling PTCH1 SMO PMC5596586__F6 Diagram showing the mechanisms of CHAC2 ATF4 CHAC2 BAX PMC8229180__F2 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells TH ULK1 CDK2 CDK4 MTOR RHEB PMC3709411__F1 Illustration of important relationships between metabolome, proteome, and genome in cancerous cells HEL-S-26 FH MYC PGAM1 HEL-S-133P PMC8229180__F1 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells CDK2 CDK4 SKP2 PMC6237070__F1 Treg suppression APC CD80 LAG3 PMC7464740__F1 General model for the Wnt/Beta-catenin signaling pathway and its regulation by the destruction complex APC GSK3B LRP6 PMC7758070__F8 Proposed model of GGGGCC repeat expansion pathogenesis TFEB C9orf72 PMC7411263__F7 Genes targeted by DE miRNAs enriched in the downstream of p53 signaling pathway RRM2B CDK6 CCND2 PMC7411263__F6 Hypoxia-related signaling pathways enriched by target genes of DE miRNAs in different tissues, including (A) the HIF-1 signaling pathway in heart, and the insulin signaling pathway in (B) muscle and (C) liver PLCG1 PCK1 FBP1 CAMK2G PLCG2 TFRC FOXO1 PDPK1 GYS2 PI3 FLT1 PHKB G6PC3 PCK2 CAMK2A AKT3 PMC11302868__F2 Four main defense pathways in ferroptosis GPX4 DHODH PMC9157004__F4 High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype MYB MSX1 FUT1 HNF1A ST8SIA1 hCG_1998026 ST3GAL6 FUT3 SIX4 HNF4A A4GALT B3GNT5 EVI1 B4GALNT1 CDX1 ETS2 ST6GAL1 B3GALT5 ST3GAL5 PMC4254557__F8 Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling GRPR ITCH PMC8613759__F7 CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1 NDUFV2 PMC11693940__F8 CXCR2 activated JAK3/STAT3 signaling pathway exacerbating hepatotoxicity associated with tacrolimus IL8RB CXCL2 JAK3 STAT3 PMC9399134__F5 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis SOX2 TWIST1 MYC VEGFA HEL113 AKR1B1 KRT14 PMC4276806__F2 Proposed pathogenic mechanisms of Alpha-syn-related Lewy body formation in PD PINK1 LRRK2 ALPI PMC7706002__F2 DEGs PPI network complex ADAMTS12 HGF RUNX2 POSTN F2RL1 KCNMA1 ADAM19 COL1A1 DCN CFH F3 GBP3 ROR2 AIM2 CPM SCAP2 PLK2 SYT14 SKIL FOS FGF2 VEGFA GPR143 PRKG1 FRRS1 TMEM47 CHORDC1 CTHRC1 PTPN22 NID2 EDN1 MGST1 SMOX SYNC PSPH CHSY3 NET1 TOX ANAPC10 PMC7204122__F4 Knockdown of IL6 in human endothelial cells affects the gene expression of proteins known to be involved in IL6-mediated signaling SOCS3 IL6ST IL6 STAT3 PMC4553397__F1 Intracellular mechanisms involved in the control of FGF21 production and action on the heart FGF21 FGFR1 NR1C1 SIRT1 UCP3 PMC3118351__F10 Pathways by which BrdU impairs epithelial repair and induces persistent inflammation in the chronic NA injury model ATM IL6 ATR PMC7204122__F8 Merged network showing the interplay between IL6-mediated signaling and interaction, binding, and adhesion of endothelial cells SPARC CCR2 SOCS3 PGR ATF2 EGFR MYC ITGA4 CD81 SELL KDR PTPN11 VWF CDH2 JUN SELE KIT PLAUR LGALS8 FOS ERG CD44 NFKB2 CXCL12 CDK9 PPARG STAT3 PMC6274918__F2 Maternal Beta-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes EGF FOXD3 HNF4A HGF FOXM1 EGFR MTOR PRL CCND2 PMC3920129__F3 TLR ligands/DAMPs, cellular location, and signaling in the vasculature IRF7 IRF3 MYD88 TIRAP PMC3024251__F6 Downregulation of miR-342 is associated with tamoxifen resistant breast tumors POLE FANCL ATR PMC6423797__F4 Regulation of Acetyl-CoA production by Beta-oxidation of fatty acids in mitochondria and peroxisomes, and the interexchange of 2-oxodipate and 2-oxogluterate by SLC25A21 over the membrane of these organelles in cells PHYKPL EHHADH PLOD2 PMC4112529__F1 Pathway for CoQ biosynthesis in eukaryotes TH COQ3 COQ2 COQ6 COQ5 COQ7 PMC6423797__F2 Regulation of immune EP expression by Tumour necrosis factor (TNF) signalling after exposure of IPEC-J2 cells to micro algae extracts in the absence and presence of ETEC TRADD PTGS2 IL6 TNF CASP10 NOD2 MMP3 CASP3 NFKBIA CSF1 CA12 FADD MLKL SELE ITCH CR1L PMC7733318__F8 Proposed working model ANGPTL4 TGFBR1 TGFBR2 SMAD4 PSG9 PMC7940767__F2 Simplified overview of the cAMP/PKA/CREB pathway in the control of GH synthesis and secretion in somatotrophs GIP GHRHR GHRH PMC7699590__F2 Platelet-derived growth factorB (PDGFB)-activated pathways mediating vascular smooth muscle cell (VSMC) migration PAK1 UNK NOX4 MTOR PMC4695187__F8 Antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells TNF PMC3352961__F3 Brain, blood, and iron: Perspectives on the roles of erythrocytes and iron in neurodegeneration VPS13A PAK1 XK RAC1 PMC7017041__F4 PARylation is required for chromatin structural changes following DNA damage RNF8 ATM PARP2 PARP1 CHD4 CHD2 EZH2 H2AX CHD3 APLF PCGF2 PMC2740793__F2 TGFB signaling pathway SMAD2 DBP SMAD4 PMC1852210__F1 Diagram of folate and one-carbon metabolism in mammalian organisms CTH GGH SHMT1 TCN2 MTHFD1 FPGS MTHFD2 MTR MTRR DHFR TYMS TCN1 HEL-S-51e AMT MTHFS SLC19A1 PMC8804151__F1 Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases ME1 PIGF PIGT ME2 ECD PMC9519149__F2 Cholesterol biosynthesis pathway, the enzymes involved in the synthesis and the diseases associated with the defective enzymes DHCR7 EBP SC5D DHCR24 CYP51A1 PMC8899174__F7 STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/B‐catenin pathway via binding to Annexin A2 in osteoporosis ALPL STARD3NL RUNX2 APC ANXA2 ALPI PMC3826841__F1 Regulation of the G2/M transition in the yeast cell cycle CIB2 HP PMC7056924__F1 Metabolic adaptations to acute metabolic stresses in the tumor microenvironment changes central carbon metabolism flow and exposes vulnerabilities VHL CAD HIF1A MTOR CD36 CAMKK2 GLS PMC2768486__F10 Possible mechanism by which BMPs and estrogen regulate GNRH production by GT1-7 cells BMP6 BMP2 BMP7 BMP4 ACTR2 PMC7269868__F2 Diagram showing the ER biogenesis pathway for membrane/secreted proteins, highlighting proteins associated with cystic disease ALG9 ALG3 ALG6 ALG10 SEC63 SEC62 PMC4763967__F1 MiRNAs biogenesis pathway AGO1 AGO2 AGO4 RAN PMC5732723__F4 Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome HEL-S-62p CD9 F10 F2R PLAUR TFPI CS THBD F8 F9 PROC C4A CPB2 PLAT C9 A2M F2 F3 C7 VWF F11 F7 C6 CR2 PMC9878249__F6 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 IRF7 TRAF3 IRF3 MAVS PMC3529762__F11 Illustration of GnRH signaling pathways necessary for FSHB induction ATF2 FSHB PMC7232018__F1 Schematic view of the role of lysosomes in the autophagy pathway HEL-S-62p GLB1 TFEB FIG4 ATP6AP2 MTOR OPTN HEL-S-130P GNPTAB PMC3392049__F3 An example pathway LEF1 MDM2 BCL2 PTEN RB1 HEL-S-22 PMC4061530__F1 Schematic representation of the ribonuclease activity of IRE1 and RNaseL showing cross-talk between the paths catalysed by the enzymes RNASEL RNASE1 XBP1 PMC11351413__F2 Biosynthetic pathway of cordycepin PURA ADA PURB ADK PMC6102368__F3 Crosstalk between Notch and tumor necrosis factor A (TNFA) in the tumor environment NUMB MOS IL1B HES1 FOXA2 PMC8004153__F1 TGFB signalling is triggered through BMP or TGFB ligands SMAD2 SMURF2 TGFBR1 SMAD6 SMAD4 TGFBR3 SMURF1 SMAD1 DKFZp781O1323 PMC6102368__F2 Interplay between IL-6 and Notch affects the anticancer immune response IL10 TH IL6 IL4 IL6R STAT3 PMC8004153__F4 The TGFB signalling pathway by miRNAs SMAD2 TGFBR1 SMAD4 TGFBR3 PMC8004153__F3 Hypothetical scheme illustrating TGFB/EMT signalling in SS SMAD2 TGFBR1 SMAD4 TGFBR3 IFNG PMC2293084__F8 PARP-1 in NFAT signaling pathway NFATC4 PARG PMC2796172__F2 Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics OPLAH CS ACACA HADHB IDI1 NME2 HEL-S-32 MDH2 ACOX1 GOT2 PC FH PDHA1 PKLR PCK2 DLAT PGAM1 HEL-S-133P FASN ENO1 AK4 DECR1 HEL-S-87p TG HEL-S-68p HEL-S-49 TMEM97 AK3 ACADVL AADAC HEL107 ECHS1 ACADM GLUD1 GLS FABP1 PMC3962152__F4 KEGG Pathway database map showing Notch signaling including proteolytic cleavage and translocation of Notch followed by transcriptional activation of Notch target genes HES5 NUMB HES1 PMC9253751__F9 Pre‐ and post‐conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta‐analysis TBK1 TLR9 IRF7 TRAF6 IRF3 IRAK4 MYD88 TNF PMC9161009__F8 The unique telomere protection mechanism in ES cells ZSCAN4 ATM MDC1 ATR BRD2 PMC3286890__F1 Wnt/Beta-catenin signalling and Beta-catenin role in adhesion in glioma cells EGF APC EGFR PMC6433075__F10 Proposed model of glycogen phosphorylase regulation by epidermal growth factor receptor in human Kit 225 T cells EGFR GRB2 RAF1 PMC9878249__F4 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 TRAF3 IRF3 MAVS PMC9878249__F3 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 IRF7 TRAF3 IRF3 MAVS PMC8843880__F6 Tumor microenvironment pathways: Cross regulation in breast cancer metastasis MMP9 MYC CD44 NOTCH1 CCND1 SOX9 PMC9399134__F1 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis HEL-S-62p VTN CD44 SMAD4 ARHA PMC7957022__F3 CAFs drive resistance-related paracrine pathways in the TME ATP7B HGF ATP7A SHH STC1 IRAK4 IL1B STAT3 PMC9399134__F2 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis HMGB1 CD47 ATM MYC HEL-S-92n ATR CDC42 PMC7957022__F5 Main signaling pathways responsible for therapeutic resistance mediated by the tumor environment TRAF6 MTOR HEL-S-133P STAT3 PMC5020319__F3 De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin PI3 IL2 PTEN PMC4813194__F2 The intrinsic apoptotic pathway is triggered by various stimuli inducing mitochondrial membrane permeabilization TRADD TNF FADD BAX PMC9142561__F9 Early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis LIMK1 ARHA SSH1 PMC3201973__F9 Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway PTCH1 SHH SMO TLR3 PMC3531712__F1 p62-interacting partners and functions KEAP1 TRAF6 MTOR PMC2645343__F2A Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy HGF PLG PMC9478949__F10 Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum GPT2 ATR PMC1919358__F5 WNT signalling KEGG pathway consisting of three subpathways with the genes on the microarray encircled (A) and expression profiles of genes during porcine myogenesis (B) TCF3 CSNK2B PMC2690004__F3 Metabolic reconstruction of H PTS APC FES PMC6712555__F2 Vascular inflammation during tumor cell extravasation and metastasis CCR2 VCAM1 MMP9 VEGFA APBA3 CCL2 CR2 IL1B PMC2775948__F2 Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery GLRX2 ENPP1 PROS1 FBLN2 NEU3 MARCO IFI30 UNK THBS1 AIM2 CST7 PTGES3 FASN LYZ FSTL1 LCN2 SLC12A7 GCNT1 C3AR1 SIRPA APOB PLAA TYRO3 SCGB3A1 MERTK TGFB1 PMC9459699__F7 Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats SELENOP GPX1 LCN2 TNF IRS1 PMC6888337__F11 Canonical pathway explaining the NASH progression from steatosis to hepatocellular carcinoma PNPLA3 VLDLR FADS2 SCD PLIN1 SMPD2 ADFP FADS1 APP HEL-S-93 FASN PMC5831833__F1 Schematic overview of the autophagy pathway and target points of its modulators ATG12 ATG3 ULK2 ATG14 DKFZp686F0183 RHEB PMC8320331__F2 Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC) DUSP4 CACNA1G RASGRF2 APC LRP5 CCND1 LRP6 RXRA PMC6073924__F5 Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges HGF FOS PMC4046519__F4 Network analysis performed on converging genes differentially regulated in response to different stresses in mouse and between different selected Flinders lines EML1 VAMP2 TUBB8 INSRR PTN TIMP3 ARC MYLK3 TUBB2A TTLL7 TTC3 PMC11978951__F5 Molecular interactions and downstream effects of the HIF-1 signalling pathway EPO MOK TFRC HEL-S-87p HEL-S-133P PMC12066067__F6 Samples for metagenomic analysis based on part of the basal metabolic pathways from the KEGG database ACLY NAPA SDHA PMC3158739__F1 Ingenuity pathway analysis (IPA) of CDF driven pathway changes in BxPC-3 cells SPARC HTATIP2 DFFB COL3A1 TRIM71 MYC CAV2 ABCG2 ARAF PMC7269823__F3 Changes in extracellular matrix (ECM), focal adhesions, and integrin signaling in ADPKD BRAF HEL-S-28 SMAD2 ARHA RAF1 MTOR LTBP1 PMC8505796__F1 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer RARA RARB HEL-S-53e PMC5811049__F7 dWnt4 switches Beta-catenin dependence during oogenesis ARHA RAC1 CDC42 PMC11534180__F6 GABAergic synapse pathway modified from the KEGG database [29] GLA GLS PMC11978951__F4 Astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique MUC1 CHUK ACACA EGFR GCK BCL2L1 MTOR HEL-S-26 TLR4 MMP2 PTPN11 MDM2 SRC CDK4 PDGFRA FGF2 NFE2L2 VEGFA ITGB1 CFTR RXRA BCL6 CREBBP EP300 CYP3A4 NFKB1 CDK2 TYMS PIK3CA ITGAV STAT3 PMC7305134__F5 TIE and the canonical TGFB signaling pathway regulated by ncRNAs SMAD2 SMURF2 TGFBR1 SMAD4 SMURF1 TF IFNG FOXP3 PMC11534180__F5 Synaptic vesicle cycle pathway modified from the KEGG database [29] SNAP25 PMC7305134__F4 TIE and immune checkpoint molecules regulated by ncRNAs APC ZAP70 BTLA PTEN MTOR EIF4B PMC7305134__F3 TIE-associated stem cell signaling pathways by ncRNAs SUFU APC PTCH1 SMO PMC1751493__F2 In normal prostate epithelial cells (a), TGFB binds to the TBRI and TBRII receptors, activating the SMAD signalling pathway and inducing the transcription of IGFBP-3 and other regulatory genes PI3 IGF1 PMC5412347__F7 The VEGF/VEGFR/HIF-1A signaling pathway and the effects of melatonin treatment leading to the activation or repression of downstream molecules in OC cell ME1 SMAD2 TGFB1 PMC2972203__F8 Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells STAT1 BAD IRS1 STAT3 PMC5938400__F1 Mechanism of action of pharmacologic therapies MAFK EGFR PMC8505796__F3 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer NF1 HGF ALDH1A3 GRB2 SP1 MTOR DDIT3 STAT3 PMC8505796__F2 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer SMAD4 HEL-S-53e PMC8505796__F5 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer SIRT2 CDK2 NEK2 HEL-S-53e BMI1 CCNE1 PMC4664161__F4 TLR4 and TLR3 sensitization TLR4 IRF7 UNK TRAF6 IRF3 MYD88 TNF TLR3 MAL PMC5437015__F8 Canonical Pathway of ‘Molecular Mechanisms of Cancer’ (IPA, p-value 0.0199) BAD HIPK2 FANCD2 MYC RHO HIF1A NF1 FYN ATM CD2 MDM2 SRC CCND1 RBL1 BAX BRCA1 FOXO1 CBL RS1 LEF1 MAX SUFU BCL2 FADD CYCS PMC3419258__F6 Proposed model of FGF23 signaling in proximal tubular cells FGF23 FGFR1 PTH SGK1 PMC5492501__F4 Myristoylation in regulating Fas/Fas ligand pathway during cytotoxic T cells activation: binding of a death ligand to Fas receptor leads to the formation of death-inducing signaling complex (DISC) BAD NMT1 NMT2 FADD BAX PMC5492501__F3 N-myristoyltransferase functions during T cell activation PLCG1 MARCKS FOS APC LCK ZAP70 MCU LAT PMC11497461__F1 Graphical representation of imatinib metabolism and transport KIT CYP2C9 BCR CYP2C19 CYP3A4 CYP1A1 ABCG2 ABCB1 CYP1A2 SLC22A1 PMC8697849__F6 Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk SRC PMC3424007__F1 Biological association network (BAN) of differentially expressed genes in common between CA and ICC EPOR EPO LONP1 INS RALA TNF TSLP THPO POLE4 GHR NPTN MPL NCOR2 PMC5372717__F4 Localization of Moco biosynthesis, FeS cluster biosynthesis and tRNA thiolation in humans FES CTU1 MOCS3 URM1 PMC6514876__F10 Model outlining biomarkers and pathways between CTCs and PMN-MDSCs interactions (CTC/PMN-MDSC cluster) isolated from blood of metastatic cancer patients NODAL CRIPTO NOTCH1 PMC7226524__F2 Methionine metabolism MAT1A PMC7518341__F1 Angiotensin-converting enzyme 2 (ACE2) causes the production of angiotensin (1-7) Ang-(1-7) from angiotensin-2 (AngII) ATR ACE2 BDNF BAX PMC5689704__F5 Screening circular RNA expression patterns following focal cerebral ischemia in mice AFP SOX2 AMOT AREG BIRC5 APC GSK3B MYC LATS1 ID1 LATS2 NKD1 BIRC2 PATJ GIG8 RASSF6 PMC6071262__F6 Schematic drawing of the 1-carbon methylation cycle PMC5586504__F1 Regulation of Wnt Signaling by Protocadherins NLK DAAM1 APC GSK3B AXIN1 LRP5 LRP6 RYK RAC1 CDC42 PMC8703161__F4 Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration CXCL16 FGF19 PMC11604295__F2 Functions of TDEVs in tumor progression MSC EGFR ADA HEL-S-87p HEL107 PFKP HK2 PMC9367256__F2 Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews EGF CCND1 PTEN MTOR PMC4662481__F7 Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer MYC PTEN JAK1 PMC2679155__F1 Integrin-RTK signaling NCK2 HEL-S-28 PTEN PMC5064990__F3 KEGG pathway for insulin signaling TSC2 BAD GRB2 INS MTOR RHEB INSR PMC8062415__F7 Hub genes associated with Interleukin-3-mediated signaling pathway IGF1 VTN IGF2 LYN FHL2 PAPPA2 THBS1 IGFALS HES1 PMC8454558__F5 Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors EGF HGF PLK1 FOXM1 PTEN MTOR CDKN2A AURKA AURKB CRKL GRB2 SRC CDK4 PMC5363569__F8 Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone POSTN VEGFA TGFB1 TRANK1 PMC6478727__F2 Differentially expressed coat color genes in Changthangi Pashmina goat and their involvement in melanogenesis signaling pathway (Adapted from ref.) DCT TYRP1 PMC3640511__F3 PRR activated signaling and antiviral responses during virus infection TLR9 IRF7 IRF8 CXCL10 DDX41 TLR3 NLRP3 TLR8 TLR7 TLR4 IRF-1 AIM2 IL1B IRF2 MAVS IFI16 IFIT1 PMC8073242__F6 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells HEL-S-49 HEL-S-30 CTRL ENO1 HEL-S-87p IL1B PGAM1 HEL-S-133P GLRX HEL-S-68p HEL-S-162eP PMC8073242__F4 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells HEL-S-49 HEL-S-30 CTRL ENO1 HEL-S-87p IL1B PGAM1 HEL-S-133P GLRX HEL-S-68p HEL-S-162eP PMC3702291__F7 Schematic model of signaling pathways in salinomycin-induced cell growth inhibition and apoptosis BAD CDK2 APC CCND1 SKP2 STAT3 PMC8241721__F2 Heme oxygenase 1: a novel oncogene in multiple gynecological cancers KEAP1 BAX PMC5868594__F2 MicroRNAs in the nuclear factor kappa B signaling pathways TRADD TRAF5 TRAF3 RELB MYD88 TRAF2 PMC5868594__F1 Nuclear factor kappa B and its activation mechanisms RELA RELB RHD PMC2796989__F1 Interleukin (IL)-13/transforming growth factor (TGF)B signalling pathways IL13RA2 IL13RA1 PMC9317121__F12 BMP Signaling Pathway in Dentin Development and Diseases PITX2 SMAD4 SMAD1 TF DKFZp781O1323 PMC9317121__F11 BMP Signaling Pathway in Dentin Development and Diseases BMP3 RUNX2 BMP2 MSX1 BMP5 DSPP MSX2 DMP1 Pax9 PMC3580410__F4 Functional interaction sub-network constructed by using module 2 genes CENPH BUB1B ANKZF1 NCAPG ZW10 KIF20A CENPE CENPN CENPO NSUN2 AURKC SPC25 PMC9317121__F10 BMP Signaling Pathway in Dentin Development and Diseases BMP3 RUNX2 BMP2 SMAD6 MSX1 SMAD4 DSPP DMP1 BMP4 Pax9 BMP5 MSX2 SMAD1 DKFZp781O1323 PMC8161962__F5 Persistent Newcastle disease virus infection in bladder cancer cells is associated with putative pro-survival and anti-viral transcriptomic changes SULF2 CEMIP CLDN1 PRKD1 SPRY2 SOX4 NKD1 LEF1 HTATIP2 GJA1 ARG2 MIA FGF19 KLK6 AXIN2 CKMT2 CDH2 SP5 INHBB GLS PMC3140915__F1 Simplified schematic of the Wnt/Beta-catenin signaling pathway APC GSK3B PMC7716749__F1 Schematic diagram showing chondrocyte stages in the growth plate during development and selected signals that regulate these processes, including PTHrP, IHH, WNTs, FGFs, BMP and TGFB, IGF1 and IGF2 IHH IGF1 BMP2 IGF2 FGF2 HEL-S-162eP PMC9272757__F2 Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway EIF4E MTOR DEPTOR MLST8 PMC6798084__F1 Nicotinamide adenine dinucleotide (NAD+) metabolism in plant cells NADK PXN HEL-S-162eP PMC4585666__F1 Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza MYB MYC CAD MPG AMT PMC5924972__F1 Saikosaponins and implications for age-related diseases NLRP3 SSB SIRT3 PMC8396502__F3 Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs IGF1R IGF1 ALK PGC YY1 BNIP3 MTOR PMC5489427__F2 Purinergic signaling in microglia in the pathogenesis of neuropathic pain CCR2 IRF8 LYN MDM2 CCL2 EIF4E PMC3688534__F10 Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors CRX CCPG1 C5orf34 MMP11 CEBPA PPP1R16B OPN1LW DNAJC21 MNDA NDUFA3 HTT PCTP WNT2B SP1 BDNF PMC8421236__F2 Daily Rice Bran Consumption for 6 Months Influences Serum Glucagon-Like Peptide 2 and Metabolite Profiles without Differences in Trace Elements and Heavy Metals in Weaning Nicaraguan Infants at 12 Months of Age CAP2 PC HEL-S-5 PMC6796064__F1 Conceptualized overview of the association between inflammation and angiogenesis HGF IGF1 RNF213 CRABP1 IFNG PMC7836022__F1 Metabolic pathways and signaling in cancer MYC CIT MAL PMC6335683__F1 Crosstalk between hepatocytes, hepatic nonparenchymal cells, and ncRNA during the pathology of NAFLD SOCS3 WNT1 IL6 TG STAT3 CD36 PMC3598852__F3 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis VASP BAD HEL-S-28 SHE ARHA PTEN CRK JUN PMC5302955__F6 IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin IGF1R ATR IRS1 PMC7716145__F3 LPS-producing bacteria interact with TLRs through the NFKB signaling pathway IL18 IL6 MYD88 TNF TRAF2 TRAF4 PMC3598852__F5 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis CD14 NLK EGF MAX NFIB FLNA GRB2 GCK ECSIT RAF1 TNF BDNF PMC3598852__F4 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis ROCK2 NLK DAAM1 LEP SIAH1 STOM APC PROC CER1 SMAD4 SKP1 ARHA PMC5648141__F1 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks PIM1 MTOR PMC6976991__F4 Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications ADIPOR1 F3 ACHE CYP2E1 INSR PMC4580963__F1 Overview of Cr metabolism and the methionine cycle HEL-S-182mP HEL-S-20 GAA PMC4491686__F3 Intracellular calcium and cell survival: Intracellular calcium activates the intermediate proteins in the signalling pathways in neuroblastoma EGF BAD CASR NGF ALK EGFR BDNF PMC5039077__F23 Overview of the GO-induced cytokine response and autophagy mediated by the TLR4/TLR9 signaling pathway TLR4 TLR9 TRAF6 IRF3 MYD88 PMC4124053__F2 Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists TNF DIABLO BAX PMC5943909__F1 Summary of the proposed mechanisms involved in the regulation of gene expression by PNX in mHypoA-GnRH/GFP and mHypoA-Kiss/GFP-3 cell models GNRHR GPR173 KISS1 PMC4669553__F3 PLD–PA involvement in lipid metabolism and signalling and impact on SA biosynthesis and signalling in plant defence PC MYC LPA HPR HEL-S-5 HEL-S-162eP GLS PMC4895251__F3 Proposed model depicts that canonical Notch signaling augments the expression of Klf4/5, resulting in conjunctival goblet cell differentiation by down-regulating proliferation and up-regulating transcription of Muc 5/ac in conjunctival epithelium MUC5AC KLF5 KLF4 PMC6900666__F7 mTOR signalling pathway identified by KEGG analysis of the target genes of the DElncRNA FLCN EBP RNF152 PTEN RHO EIF4E MTOR DEPTOR RHEB TTI1 RICTOR GAB2 SESN2 EIF4B PMC6900666__F6 CAM signalling pathway identified by KEGG analysis of the target genes of the DElncRNA CDA CD99 CD6 ESAM CLDN2 SPN SELL MPZ CD2 CDH2 PTPRM ICOS SELE CD34 APC NRCAM CTLA4 TIGIT ITGB1 tal-1 PTPRC ITGAM CNTN2 CDH4 ITGA6 CD22 PTPRE CD40 SELP CD226 JAM2 CD36 PMC7401253__F5 Scheme highlighting the pathophysiology of neurodegenerative disorders and post-ischemic consequences along with indicating the underlying mechanism of neuroprotective action of algal compounds ACHE BDNF APOE PMC3907011__F5 Schematic diagram of the Bcl-w-induced signaling pathway by the activation of Sp1 SOX2 SP1 PMC9230675__F6 Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells ATM BRCA2 RAD51 PARP1 BRCA1 PMC6406872__F3 Structural hotspots and signaling pathways that are essential to the hepatic phenotype of highly differentiated HepaRG cells VASP HGF CTBP1 EGFR INS TPM3 FBN1 EZR TFRC RHO RDX EPHB4 GPC1 HEL-S-108 LIN7C SPTBN1 CXADR IL17RA HEL114 PTPN6 CDH2 SP1 TJAP1 CGN PARD3 F11R PRKCI ANTXR2 ADAM9 CLDN1 M6PR SKP1 SCRIB RBX1 FCGRT TLR3 PTPRF NLK CACYBP ASGR1 TIMP1 LAMB1 HSPG2 PSEN1 LSR LMO7 CDC42 PMC3494149__F6 VANTED integrated pathway map of quantitative regulation of metabolites and enzymes of primary metabolism under nitrogen limitation in Chlamydomonas reinhardtii UROS GIP PALM CIT MDH2 MAL PMC5515036__F1 Biosynthetic pathway of cysteinyl leukotrienes (cysLTs) and cross regulation of their receptors GPR17 LTA LTB PMC5811677__F3 Key signaling pathways affected by CD5 expression STAT1 CD5 VAV1 LYN SYK MTOR STAT3 PMC12240740__F3 Network pharmacology results THBD MYC BCL2L1 CCL2 RB1 HIF1A IFNG MMP3 PRKCA STAT1 MMP2 MDM2 NOS2 IRF-1 CXCL11 IL1A FOS TP63 CXCL10 VEGFA ADRB2 HMGCR RXRA APOB SLC6A3 CDKN1A HEL-75 BCL2 NCF1 PCNA EGF CHUK MPO NR3A2 PGR ACACA EGFR TOP2A HSF1 CYP1A2 INSR CHEK2 RXRB PLAT AHR E2F2 opn F3 CRP IL2 CD40LG CYP1A1 ABCG2 IL4 IL1B JUN SELE FASN BAX MMP9 PTGS2 IGF2 NR3C1 CD44 PTGES CXCL2 IL6 HEL-S-130P NR1C1 IKBKB CASP3 NFKBIA CYP3A4 ERBB2 RELA RAF1 MCL1 PPARG STAT3 PMC2854298__F8 AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1 AATF EIF2A WFS1 STAT3 PMC6108862__F4 Functional analysis of transcription factors and genes in dysregulated miR-FFLs FOS MYC APP CTF1 ARHA RAC1 GATA4 STAT3 PMC7554191__F9 Mechanism of EMAP II/ S1P signaling and modulation of S1P homeostasis EGR1 S1PR2 S1PR1 S1PR3 S1PR5 SPHK1 S1PR4 PMC4002915__F2 Signal pathways of IL-17 GSK3B TRAF3 IL17RA IL17A TRAF6 JAK1 IL17RC PMC6909960__F1 Multiple factors regulate COX-2 expression AHR NGF IRAK1 PTGS2 EGFR CDC37 HSD17B7 MYD88 TRAF2 PMC5910288__F3 Interactions between cellular metabolism, the circadian molecular clock, and ion channels INA NAMPT CSA2 PRX SIRT3 PMC4136892__F7 Signaling pathway regulation in human schwannomas NF2 AXL PMC3539739__F1 Oncogenic Transcription Factors: Cornerstones of Inflammation-Linked Pancreatic Carcinogenesis EGF HGF EGFR TNF CCND3 VMP1 CDK6 VCAM1 SUFU CXCR4 SHH CCND1 SMO CDK4 STAT3 PMC4574709__F2 Meta-Analysis of Microarray Data of Rainbow Trout Fry Gonad Differentiation Modulated by Ethynylestradiol E2F4 PLK1 CDK2 MDM2 SMAD4 DBF4 RAD21 CDK7 CDC45 PCNA SKP2 PMC8276021__F4 T Cell Protein Tyrosine Phosphatase in Glucose Metabolism STAT1 POMC NPY AgRP GHR JAK1 PMC2940738__F7 ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans IGF1 PMC5145803__F1 Redox states of the mitochondrial NAD and NADP pools are determined by a range of interconnected pathways HEL-S-26 AGA NADK NNT PRX HEL-S-32 NDP PMC8492275__F1 Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt Beta-Catenin Signaling Pathway APC PMC5726210__F3 The vitamin K cycle MGP GLA PMC5161652__F7 Signaling events leading to MYC and YAP upregulation MYC MTOR PMC6289210__F1 MALAT1 in cancer pathways.Notes: MALAT1 promotes generation of the six phenotypes of cancer NLRP3 ELAVL1 FOXM1 SYK IL6 DKK1 CDH2 BAX PMC6102368__F5 VEGF and Notch interaction in physiological and tumor angiogenesis NOTCH2 FGF4 FGFR1 VCAM1 NRP1 NOTCH1 NOTCH3 PMC6169142__F3 The protein C pathway CS PC C4B_2 F2 PMC8347175__F2 Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx FADS3 DEGS1 DEGS2 PMC6370526__F1 Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology ATF4 TRAF2 PMC10237023__F2 Intratumour microbiome of pancreatic cancer NLRP3 CXCL1 CARD9 TLR4 IL33 IL8RB SYK CXCL2 CD81 PMC11806117__F7 Amino acid metabolism during liver repair and regeneration EGFR CCND1 FOXO1 FASN GLS PMC11806117__F6 Lipid metabolism during liver repair and regeneration EIF2S1 ZNRF3 EGF RNF43 HGF NCOR1 FOXM1 EGFR FGFR4 PTEN MYD88 NR1C1 HMGCR CYP7A1 MIER1 COX2 HEL-S-67p CPT1A TRIB1 CCND1 ABCA1 FASN PMC11806117__F4 Canonical signaling pathways involved in liver repair and regeneration ZNRF3 CXXC5 RNF43 SOCS3 APC NOX4 SMO NR1C1 SIRT1 AURKA STAT3 PMC5998149__F5 Pathway analysis of selected metabolites PMC5390009__F1 Downstream signaling pathway of cytokines sharing the common G chain receptor: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 STAT1 IL15RA JAK3 STAT3 PMC5056018__F1 Estrogen Signaling Pathway MYC SRC TGFA TF PMC9709426__F2 Targeting ferroptosis, the achilles’ heel of breast cancer: A review GPX4 FACL4 SUFU SLC7A11 FGFR4 DKK1 DDR2 ACSL3 TCF4 HLF STAT3 PMC9709426__F1 Targeting ferroptosis, the achilles’ heel of breast cancer: A review GPX4 LPCAT3 SLC7A11 SLC3A2 POR TF HMGCR PMC2064799__F9 New calpain-dependent switch that controls cell spreading and retraction SRC ARHA RHO CDC42 PMC7697663__F3 Early antigen-driven transcriptional pathway in effector CDT8 T cells and in exhausted CD8 T cells RUNX3 TOX TNF IRF4 BATF PMC11594238__F4 Hormone synthesis and signal transduction pathways NCL ALK ERF EBF2 CPD PMC7697663__F1 c-Jun/activator protein-1 (AP-1) regulation and biological activity ATF2 IRF4 BATF PMC6507908__F9 Elevated androgens alter intrafollicular regulatory mechanisms that impact the expression of VCAM1 and the expansion of VCAM1+ cells in the stroma NR2F2 VCAM1 FSHR CYP17A1 PMC5327483__F4 New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin TLR4 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 CASP8 IL1B FADD TIRAP PMC10367551__F8 Mechanism by which miR-552-3p alleviates liver fibrosis and inflammation COL3A1 SMAD2 TGFBR1 TGFBR2 SMAD4 CCL2 COL1A1 ACAT2 PMC11577739__F9 Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPARG /FDX1 signaling FDX1 RUNX2 ACTA2 BMP2 ATP7A DLAT PMC3079441__F3 Pharmacological activities of cardiotonic steroids such as ouabain EGFR SRC NACA2 PMC8677397__F5 Sishen Pill Maintained Colonic Mucosal Barrier Integrity to Treat Ulcerative Colitis via Rho/ROCK Signaling Pathway NOTCH1 WAS RHO PTEN IL1B PMC4931096__F1 Biosynthetic pathways and the transformation of H2S in the mammalian body VIT DAO PMC12228400__F11 Schematic diagram illustrating the antagonistic mechanism employed by ASFV MGF505-4R on IFN-I responses TBK1 CGAS STAT2 IRF3 TYK2 JAK1 PMC4933697__F2 Signaling pathways involved in platelet-mediated NET formation TLR4 MPO CSK SRC PMC8850700__F1 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer EZH2 MTOR PMC5818890__F4 Common highly linked molecules and their most significantly related signaling pathways and functions in the “matrine-CRC” merged network HMGB1 GPT MYC PTEN RHO TNF IFNG PMS2 CREBBP TLR4 BCR HEL-S-11 SRC MSH2 RAN CP PMC8850700__F2 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer MTOR GPR39 PMC8773517__F3 Oxysterols in the Immune Response to Bacterial and Viral Infections CH25H ATF4 EIF2A OSBP PMC8773517__F2 Oxysterols in the Immune Response to Bacterial and Viral Infections CYP27A1 CH25H IRF7 IRF3 GPR183 PMC9208265__F3 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy HMGB1 GPX4 TLR4 MAPK3 MAPK1 CCL2 LPO MTOR PMC9208265__F2 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy STAT1 NLRP3 GPX4 SLC7A11 GZMA SLC3A2 LPO GSDMB GSDMD CD36 DFNA5 PMC7382747__F3 Relevant signaling pathway in itaconate-induced anti-inflammatory and antioxidative effects IL16 KEAP1 F3 ATF3 HEL-S-87p CAD HEL-S-162eP PMC4435780__F1 Adipocyte receptors that have been proposed to promote the browning of white fat or maintenance of a brown adipocyte (BA) phenotype PRDM16 UCP1 PLIN1 ATF2 BMP7 NR1C1 SIRT1 TRPM8 PMC3181077__F1 NFKB activation pathways and the impact of S-glutathionylation RELA RELB IL1B PMC9304715__F5 Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NFKB Pathway TLR4 MPO PEBP4 BAX PMC7204633__F2 Hypoxia driven interaction network that links CHI3L1 and TNFRSF12A to thyroid cancer TNFRSF12A ALB MMP9 VEGFA INS BCL2 CHI3L1 PMC4614824__F1 Cystathionine Gamma-lyase (CSE), the biosynthetic enzyme for cysteine is depleted in Huntington's disease (HD) at the transcriptional level NHS SP1 TAF4 PMC3413998__F6 Canonical Wnt signaling pathway APC GSK3B MYC LRP5 LRP6 FGF20 PMC9100302__F1 An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19) ACE2 PMC7013599__F4 Gene expressions in the fatty acid biosynthesis pathway (Ko00061) in response to Bgt infection FBL FES FASN PMC8524389__F4 Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial TH APP PMC9395173__F1 Using human data on cardiovascular risk associated with T1DM to guide mechanistic studies in mouse models S100A8 APOC3 S100A9 PMC8529875__F5 Mini Review: Biomaterials in Repair and Regeneration of Nerve in a Volumetric Muscle Loss HEL-S-62p NRF1 UQCRH YY1 TFAM PMC8836112__F1 Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport INSR CBL PMC6362621__F1 VEGFA-VEGFR2 signaling pathways and their pharmacological inhibition occur across the glomerular filtration barrier BRAF VEGFA MTOR PMC1828071__F1A Intracellular Signaling in Insulin-mediated Regulation of Drug Metabolizing Enzyme Gene and Protein Expression PDE3B BAD PDK2 GSK3A EIF4E MTOR CRK FOXO1 RHEB TSC2 RICTOR TSC1 IGF1 GRB2 GRB10 EIF4B PMC4855676__F2 NFAT signaling pathway FOS JUN IRF2BP2 PMC8001776__F2 Routes for the in vivo production of glyceraldehyde (GA)/methylglyoxal (MGO) GLO1 HEL-S-162eP PMC3877547__F9 Schematic model of cancer-derived IgG to enhance cell growth and proliferation through inducing the production of a low level of ROS RAN PMC6400807__F7 The sketch of the mechanism of lncRNA SNHG16 on JAK2/STAT3 signaling pathway STAT3 PMC5932832__F3 Proteins of acute-phase signalling at stage II compared with stage I in non-responders to autologous chondrocyte implantation (ACI) FGA CORT HRG HAMP CFB PLG HEL-S-92n MBL2 AMBP HEL-S-78p F2 CRP AHSG LBP APOH OSM PMC9400419__F1 Targeting the Hippo pathway in heart repair LATS1 LATS2 PMC3732055__F1 PAM and Copper – a Gene/Nutrient Interaction Critical to Nervous System Function ATP7B ATP7A ATOX1 PMC4855676__F5 Regulation of the apoptosis signaling pathway by NFAT proteins CAD TRIM17 BDNF DIABLO BAX PMC3256998__F5 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells COX2 CD74 PMC3928478__F2 Inositol phosphates and Akt/PKB inhibition, a potential Akt/PKB feedback mechanism.Note: Adapted from Cell, 143(6), Manning BD, Insulin signaling: inositol phosphates get into the Akt, 861–863 IP6K1 IRS1 PMC5707523__F1 Viral modulation of death-receptor mediated apoptosis TRADD TNF TRAF2 FADD BAX PMC4464690__F3 Crosstalk between Wnt, PTH and BMP signalling in cartilage and bone cell lineages MSC LRP5 LRP6 PTH DKK1 PMC3256998__F6 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells PAK1 LBP PMC9103886__F1 Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study HGF MMP2 MMP9 CCND1 SRC BCL2 STAT3 PMC5915505__F2 HIF degradation pathway in normoxia and its stabilisation in hypoxia and pseudohypoxia FH VHL HYI PMC6770306__F2 DNA damage response network in SCLC cells PALB2 ATM ATRIP RAD51 ATR RAD21 BRCA1 PAXX PMC4075038__F3 Signal Transduction in Vasculogenesis and Developmental Angiogenesis HDAC7 IQGAP1 SRC SHB CDC42 PMC4233246__F7 A model of how a p66B/Sufu complex inhibits Gli transcriptional activity and a Mycbp/Gli complex enhances Gli transcriptional activity in the nucleus SUFU MYCBP PMC5861430__F8 Working model of the molecular mechanism of APE2-mediated ATR–Chk1 DDR pathway from a defined SSB structure TOPBP1 ATRIP SSB ATR PCNA PMC4511103__F4 Programmed Cell Death in Animal Development and Disease WNT3 CP PMC8484370__F3 Distinct TLR signaling in the salamander response to tissue damage TBK1 TLR5 TLR9 IRF7 IRAK1 ATF2 TRAF3 TRAF6 IRAK4 IRF3 MYD88 TLR1 TLR3 TLR7 TAB3 PMC4940079__F6 Differentially expressed gene distribution in the rno03320 pathway UBC PLTP UCP1 AQP7 HEL-S-28 LPL PMC6698931__F1 The Function and Therapeutic Potential of Epstein-Barr Virus-Encoded MicroRNAs in Cancer CASP3 BAD TRADD CASP9 MST065 CASP10 TNF TRAF2 CASP8 FADD BAX PMC4940079__F7 Differentially expressed gene distribution in rno03320 pathway UBC PLTP UCP1 AQP7 HEL-S-28 APC LPL PMC3159971__F2 Mathematical model of dual negative feedback regulation of JAK2-STAT5 signaling EPOR SOCS3 EPO PMC8717028__F1 Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder AHR PPARG IL1B GSDMD PMC8580948__F3 Inhibition of Wnt-Beta-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells CTCF JUN TCF4 PMC3999257__F4 NRG1 signalling and neurite formation mediators NFKB1 STMN2 UXS1 REL PRKCH PMC7005066__F1 Unfolded protein response (UPR) signaling during bacterial infection CXCR1 HEL-S-11 ATF4 EIF2A FADD PMC12031541__F1 Interaction of autonomous parvoviruses with cellular DDR factors ATM TOPBP1 BRCA2 ATRIP RAD50 RAD51 ATR H2AX MRE11A BRCA1 PMC6237163__F7 The effect of fold change with RNA-seq analysis for toll-like receptor nine signaling pathway in lung TLR9 IRAK1 NFKB1 IRAK4 MYD88 PMC6237163__F6 Result of RNA-seq mainly involves the signaling pathway TLR9 MAPK8 IRAK1 MAPK14 CXCL8 TRAF6 CCL5 MYD88 CCL3L3 IFNG PRKCA MAF VAV3 FYN MAPK1 CSF2 CCL4L2 FOS MAP3K7 TNF HRAS IL2RG LAT AKT3 PLCG1 IKBKG CHUK IL12A MAP2K3 BTK LCP2 IL18 TLR7 IL4 GATA3 IL10 IL13 NFATC1 IL6 IL5 MAP3K7IP1 IKBKB NFKBIA MAP2K1 GAB2 NFKB1 LYN MAP3K8 SYK RAF1 PMC12031541__F3 AAV life cycle and DNA Damage Response (DDR) signaling ATM TOPBP1 ATRIP RAD50 ATR H2AX MRE11A PMC4132269__F2 Vascular inflammation, NK cell/monocyte crosstalk and angiotensin II in cardiac ischemic injury CCR2 VCAM1 CD48 MICA CD40 RAI1 PMC3773046__F1 Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast Lifespan FHL1 NDP POLI PMC9023073__F7 Mechanism of Lipopolysaccharide Escaping the Intestinal Barrier in Megalobrama amblycephala Fed a High-Fat Diet GPR78 MUC2 CD36 PMC7821221__F1 Wnt5a exerts its intracellular effects by activating two non-canonical Wnt signaling pathways, or the interplay with the canonical Wnt signaling pathway WNT3A APC LRP5 LRP6 ROR2 PMC6515307__F1 Mechanisms contributing to regulation of tumor clearance by effector cells IL10 APC IL2 CD80 CTLA4 PMC9367504__F8 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis NLRP3 IL8RB CXCL2 IL1B PMC9367504__F7 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis CXCL1 IL8RB MYD88 PMC6252103__F2 aspartate Beta-hydroxylase (ASPH) may affect the progression of pancreatic cancer through the activation of Notch signaling pathway PTGS2 MMP9 VEGFA NOTCH1 PMC7248261__F1 Pathophysiology of allergic contact dermatitis (ACD) APC IL1B IFNG PMC6252103__F1 Transcriptional regulation of aspartate Beta-hydroxylase (ASPH) IGF1R IGF1 ASPH IRS1 PMC4250230__F4 Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond IGF1R HGF NRAS PMC7242326__F9 Summary of the role of AHR ligands in blocking TGFB induced collagen deposition and myofibroblast formation in Thyroid eye disease AHR PMC9367504__F1 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis TRADD TRAF2 FADD PMC9130478__F3 Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases IRAK1 EGFR MYC DROSHA TRAF6 IRAK4 CCL2 MYD88 TNF AGO2 CYLD KDM6B TAB3 PMC8102492__F7 4-1BB-p38 MAPK-Dkk1 signaling pathway in BMSCs of aged mice APC LRP5 LRP6 DKK1 PMC6063970__F4 Mapping transcripts on KEGG pathway OASL BAD HP ATM MDM2 PTEN POR MTOR ATR PMC5943174__F1 Plasticity of myeloid-derived suppressor cells in cancer IRF8 NOS2 ARG1 STAT3 CCL3 PMC6436660__F3 Bioinformatics and miR-135a-3p gene profiling predicts p38 as a targeted signaling pathway PPT2 USHBP1 GPSM1 OASL NAXD ACSF2 GMPPB MZF1 ZNF174 FDXR NOC4L ZNF232 CPNE1 WDR83 KRI1 EXD3 FAM124B ZNF768 EIF2D ZSCAN18 LYSMD2 FADS1 KRTAP19-5 COMMD4 ZSCAN25 DHODH CCDC22 PMC6998289__F2 Small peptides encoded by circRNAs and lncRNAs regulate tumor invasion, metastasis, and proliferation EDC4 DCP2 GSK3B PMC6998289__F1 Small peptides encoded by circRNAs and lncRNAs regulate tumor proliferation SOX2 USP28 CCND1 FBXW7 DTL PCNA PAF1 POLI PMC4791269__F5 Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network CCNA2 CS FOXO3A MYC RALA ARHA MTOR HRAS CDC34 FBXW7 CDK6 IKBKB MDM2 CDK4 PCNA RGL2 AKT3 PMC3216974__F7 S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer TSC2 TSC1 PIR PTEN RHEB PMC3579607__F2 Mechanisms underlying modulation of HER2-directed therapy cardiotoxicity through aerobic exercise ERBB4 ERBB2 ERBB3 SRC NRG1 MTOR GATA4 PMC2820587__F3 AURKA interactions CLDN1 MDM2 CCND1 AURKA BAX PMC3579607__F1 Mechanisms underlying HER2-directed therapy cardiotoxicity ERBB4 ERBB2 ERBB3 SRC NRG1 MTOR GATA4 PMC8264427__F3 Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes CCR2 IL13RA2 CXCL8 IL8RB CCL2 MTOR CHI3L1 PMC2704458__F2 Histone Acetylation in Drug Addiction CDK5 FOSB HDAC5 PMC4447103__F1 Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy SOCS3 TRADD GOPC TNF MTOR NR1C1 LEP POMC NPY AgRP UNK LEPR TRAF2 STAT3 PMC8124433__F10 Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease BACE1 MMP3 HMGB1 AGER ADRA2A APP IL1R1 PMC4036091__F2 Schematic diagram representing the hypothetical mechanisms of the insulin-dependent systemic (I) and insulin-independent direct (II) effects of metformin in the endometrium TSC2 TSC1 IGF1R PTEN MTOR IRS1 PMC11532857__F5 MiRNAs in metastasis of HCC SRPK1 ADAM10 STAT3 PMC11532857__F4 MicroRNAs in EMT process SRPK1 MTOR IRF-1 STAT3 PMC12180341__F9 Potential mechanism by which PTS alleviates renal fibrosis PTS SMAD2 PMC5369137__F1 Metabolic pathway of clopidogrel and its targeted receptor CYP2B6 CYP2C9 CES1 CYP2C19 CYP3A4 CYP1A2 PMC8863767__F11 Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages EBI3 IRF7 CCL7 IRF3 CCL2 TLR1 TLR3 IL15 ISG15 TLR4 JAK1 IL27RA IRF-1 PMC11532857__F7 MiRNAs regulating angiogenesis in HCC HGF PDGFRA MMP2 DLL4 PMC11532857__F6 MiRNAs regulating glycolysis in HCC PTEN MTOR HEL-S-133P HK2 PMC11526712__F1 Study workflow: Four differential microbial strains were found in the fecal microbiota of Laiwu pigs and Lulai black pigs STAT1 TSC2 TSC1 CD163 PIGS RHEB PMC11526712__F8 Pathways through which E TSC2 TSC1 PTEN RHEB PMC2667750__F8 Proposed pathway for polyoxin biosynthesis NHS POLE POLK POLG POLL POLM POLI PMC3554122__F1 Summary of checkpoint factors MRC1 RAD17 PMC12115143__F1 Integrative scheme of multistep phosphorelay in plants RAC3 RRAS PMC7156858__F2 Suppressive role of MIR143‐3p in rat sarcoma (RAS) signaling pathway NF1 EGFR NRAS HRAS MTOR PMC4187614__F2 Rho GTPase signaling pathways regulating neuronal survival BAD RHO PTEN BAX PMC8304872__F7 Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis CASP3 HMGB1 RIPK1 CASP9 RIPK3 CAD H2AX XBP1 CASP8 ORAI1 FADD STIM1 PMC6901991__F1 Schematic diagram of a cell with insulin/IGF signaling cascades depicted BAD IGF1R IGF1 M6PR IGF2 IGFBP7 IGFBP2 MTOR PMC8518101__F2 When to Measure Plasma Homocysteine and how to Place it in Context: The Homocystinurias CBLC CBL PMC7731760__F4 Metabolic pathway of D-mannitol in O PFKFB2 PFKFB4 PMC9277484__F4 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland NRG3 TBX2 TBX3 MSX1 LRP6 HOXC6 TNF PAX3 PYGO2 LEF1 LRP4 GLI3 MSX2 GATA3 PMC10610064__F1 ABL Kinase Activation and Signaling in Solid Tumors ABL2 CXCR4 CCND1 SRC RHO DAB1 MTOR NQO1 TRIO PMC7731760__F5 Metabolic pathway of cordycepin in O RRM1 RRM2 PURA PURB ADK PMC9277484__F3 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland EDAR NRG3 ERBB4 IGF1R SUFU PTCH1 GLI3 FGF10 SMO TNLG7C IRS1 BMP4 PMC3945866__F6 In addition to the known pathways that activate hepcidin expression, we show that Ras/RAF-triggered signals and the mTOR pathway are involved in hepcidin suppression CREBBP FOS YY1 IL6 MTOR PMC2270259__F3 Central metabolism CIT MAL PMC10889086__F1 Bruton’s Tyrosine Kinase Inhibitors: Recent Updates CD5 PLCG2 MYD88 CD69 BTK CARD11 BCL10 BCR BASH CD22 LYN CD80 CD19 PMC7988095__F2 AhR signaling pathway AHRR AHR PMC8744248__F3 Recent advances in systemic therapy for hepatocellular carcinoma APC HEL-S-92n PMC3272705__F1 Subcellular itineraries of paradigmatic substrates of ubiquitin-dependent sorting pathways USP2 EGFR OSM CBL PMC11906681__F3 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation TSC2 TSC1 IGF1R IGF1 TBC1D7 MTOR RHEB PMC8539723__F3 Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis SOCS3 SOCS1 STAT3 PMC6844630__F1 Mechanisms of action of miR-21 showing the regulation of the WNT signaling pathway in NAFLD mice GSK3B LRP6 PMC11906681__F2 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation SUFU PTCH1 GLI3 SHH SMO PMC5718065__F8 Schematic diagram illustrating potential interactions and changes in Ten-m3 KOs EPHB1 EPHA7 ZIC2 PMC7438890__F1 Effect of local RAS on normal and leukemic hematopoiesis, as well as plasticity and systemic circulation, are shown () CTSA STAR PMC7204005__F3 miRNA-28-3p promotes cell proliferation through the MAPK signaling pathway and participates in the regulation of diabetes MAPKAPK2 TRADD TRAF6 RAC1 TNF HSF1 GRB2 SRC BCL2 OSM TRAF2 JUN CDC42 PMC5838831__F4 Sinalization cascade for genesis of medulloblastoma SHH PMC7204005__F5 miRNA promotes signal transduction and glucose protein binding through the TGF-beta signaling pathway and participates in the regulation of diabetes SMAD2 ATF2 GRB2 SMAD6 SMAD4 ARHA SKI MAP3K7IP1 PMC5833345__F7 FBXL10-promoted DLBCL cell proliferation BCOR PRC1 PCGF1 BCL6 PMC7204005__F4 miRNA-28-3p promotes cell proliferation and migration through the IGF signaling pathway and participates in the regulation of diabetes BAD IGF1R IGF1 IGF2 GSK3B GRB2 PTEN EIF4E MTOR CRK PMC6457250__F5 Metabolic control of macrophage function IL1B IRF-1 BMP4 STAT3 PMC9086853__F12 Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells HEL-S-30 HEL-75 HEL-S-304 ENO1 PSPH PFKM HEL-S-87p HEL-S-68p HEL-S-162eP PMC1124928__F4 Coagulation, fibrinolysis, and angiogenesis in cancer TFPI PLG PF4 TF PMC5739687__F3 PPI network of proteins (A) up- and (B) down-regulated in renal oncocytoma CD9 GLB1 TIMM44 KRT19 NNT ECHDC2 MDH2 PALLD GOT2 PC ACADS DUT PRDX5 OGDH TFAM SDHA SNCA ITGB3 LYZ NDUFB9 ENO1 HEL110 CTNNA1 SNRPC PPIF G3BP2 OGDHL RAB11FIP5 IGF2R UQCRB S100A10 HEL-S-97n LRPPRC ASPN ALDH7A1 HEL-S-108 COA6 TLN2 ACO2 SLIRP VWF DHRS4 HEL-S-70p DCXR MFAP2 COX6A1 CNN2 PHB2 CHCHD2 DLAT NDUFS6 NDUFV2 CHCHD4 BDH1 NDUFS3 RPS11 MTHFD1 SLC25A4 MRPS18A LCP1 SLC25A3 ATP6V1B1 COX17 MRPL17 NDUFA10 RPS4X MRPL14 DNAJC19 MRPL43 GAA PRELP DCN GMPR2 NDUFS1 TIMM9 ANXA2 COX6B1 PCK2 COX7C NDUFS8 UQCRQ AKAP12 HBD VCAN CHDH DPYSL3 FXN ISCU DLD UQCRC2 SSBP1 HEL-S-22 APOB TXN2 GFER SUOX ITGAV FXC1 PLEKHA7 EHHADH MYLK ASL CS HSP90AB1 CNDP2 HEL-S-14 TSFM AMBP ITIH4 JUP F2 MRPL53 TIMM13 PPA2 HEL-S-8a APOA2 MRPL11 SLC25A5 CD44 CHCHD3 PCCA HEL-S-130P GPX3 NDUFA2 RNASET2 AK3 UQCRH PKP4 HEL-S-51e CKMT2 ATP6V1F CYCS HEL-S-29 PSME2 PMC7988095__F1 Intestinal stem cell compartment and molecular cascades related to AhR signaling EGF APC EGFR GRB2 GPR49 MTOR HES1 PMC3394958__F6 Schematic showing observed protein level alterations in VSCC proteome in the context of HPV infection STAT1 OAS2 OAS3 EGFR CASP14 PRKDC FADD MX1 PMC7938726__F1 Diagram of osteoimmunology and potential regulatory sites of TCPTP PREB CXCL12 PMC5413910__F4 TNF-induced canonical NFKB and apoptosis pathways TRADD CYLD SHARPIN TNF OTULIN TRAF2 FADD PMC6497758__F3 Proposed Schematic diagram of the interaction of Mda5 with LGP2 in the RLR signaling pathway TBK1 IRF7 IRF3 MAVS PMC6497758__F2 Proposed Schematic diagram of Mda5 signaling pathway in Teleost based on a Mammalian Model TBK1 IRF7 IRF3 MAVS PMC7672768__F2 Protein-protein interaction (PPI) network constructed using the STRING online database and Cytoscape software HEL-S-75 PLAUR PTN ALDH3A2 TFRC HCTP4 SPARCL1 PTHLH GAST CLU PRNP FST AOX1 TNC COL14A1 CFD RECK APP KRT4 CXCL12 DPT HEL-S-117 LAMC2 PMC5601664__F7 SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells SUMO2 SENP7 SENP6 SENP1 RAC1 SENP2 CDC42 STAT3 SENP3 PMC8229713__F7 Two-way rectification method for identifying differentially expressed genes by maximizing the co-function relationship CASP3 NLRP3 CD3D NOD1 MYD88 TNF CASP8 IL1B IFNG PMC8308893__F6 Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice BACE1 GSK3B CDK5 ARG1 PMC1993861__F7 Model summarizing the hypothesis on narciclasine-mediated apoptosis FADD BAX PMC11922768__F8 The molecular architecture of plaque-associated axonal spheroids AP2A1 PPP3CA MYH10 UBB RYR2 GAA SLC8A2 NCKAP1 SPTBN1 CTSA ATP2B3 NTRK2 APOE VPS35 ARCN1 ARHGEF7 TUBB GANAB ENO1 GRIA2 ATP2B1 RHEB CALM1 TUBA1A VAMP2 G3BP2 ARPC3 LAMTOR1 GRIA4 CLTC PSMD2 RRAGA PSMD1 SYNGR1 ATP8A1 SYP DYNC1H1 HEL-S-62p VPS16 ACTN1 MTOR CLU GABRB3 APP HEL-S-111 VPS41 ATG9A LAMP2 RTN3 SNAP25 HEL-S-130P NAPA SYT1 PIK3R4 CANX RTN1 ATP2B2 SYT11 KIF21A CAMK2A PMC4135307__F1 Adaptive immune resistance of acute myeloid leukemia (AML) ICOS IFNG PMC7865845__F2 Role of the discussed NLRs in type I interferon signaling TBK1 CGAS TLR9 IRAK1 NLRP2 NLRP6 TRAF3 TRAF6 DHX15 IRAK4 MYD88 RIPK2 NOD2 TLR7 TLR4 NOD1 NLRC3 NLRC4 IRF7 IRF8 NLRP12 NLRX1 IRF3 NLRP11 TLR3 NLRP14 MAVS PMC4036234__F2 Cargo recognition and packaging in selective macroautophagy CALCOCO2 SQSTM1 LGALS8 OPTN PEX3 PMC9696247__F1 Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia FGF21 PINK1 BNIP3 PMC3539299__F1 The phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt pathway and its relationship to the androgen receptor (AR) based on the results of three papers published recently by the laboratories of Charles Sawyers, Damu Tang and Hong Wu EGR1 MAN2C1 FKBP5 PTEN EZH2 MTOR PMC10215262__F2 Studies related to the role of the Wnt/Beta-catenin signaling pathway in Acute Myeloid Leukemia KMT2A RUNX3 FOXM1 WNT1 FZD4 DKK1 WNT2B SOX17 WIF1 WNT10B PMC3423951__F1 The interplay between pituitary hormones and main signaling pathways of the IGF system in thyroid, adrenal and ovary cancers TSHR GRB2 FSHR MTOR IRS1 PMC3483025__F1 Metabolic pathway of tetrapyrrole biosynthesis in plants FECH UROD UROS POR CPO PMC10215262__F1 Canonical Wnt pathway APC LRP5 LRP6 ARHA ROR2 BCL9 JUN ROR1 CDC42 PMC9368769__F4 Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases CTSK GSK3B OSCAR DAP TRAF6 ATP6V0D2 PMC12128263__F2 Three metabolic pathways in cells ENO2 MTOR HEL-S-133P GLS PMC6693056__F16 Summary of key estrogen-dependent mechanisms in endometriosis SF1 GATA6 HSD17B2 IL1B PMC12128263__F4 Schematic diagram of cysteine metabolism GPX4 SLC7A11 SLC3A2 PMC3929246__F1 Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment CD14 TLR5 TLR9 IRAK1 IRAK2 TRAF6 IRAK4 IRF3 LPA MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 TIRAP PMC8380544__F1 Novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder TLR8 TLR7 TLR9 CRABP1 MTOR TLR3 PMC6297399__F5 String pathway enrichment analysis revealed strong associations (P=0.007) of the identified prognostic genes (colored nodes) EGF KIT HGF PDGFRA DKFZp781B1423 EGFR SMARCC2 SMARCC1 ACTL6A SMARCA4 PTPN11 MDM2 KITLG PMC5904546__F6 Cardiomyocytes and fructolytic pathway are strongly affected in P7 hearts PFKFB2 HEL-S-87p TG HK2 PMC2805044__F1 The Akt/mTOR pathway in tobacco-carcinogen induced lung tumorigenesis TSC2 PI3 BAD TSC1 PTEN RHEB PMC5904546__F5 Comparative analysis of differentially expressed proteomic and differentially regulated metabolomic data ACSL5 HADHB ACSL1 HSD17B10 HEL-S-5 PMC9371865__F8 LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway GPX4 KEAP1 LTBP2 PMC7870784__F4 Depiction of MAPK signaling pathway dysregulation and miRNAs in the KEGG database NF1 IGF1R ALK MIA PMC7870784__F3 Depiction of the MAPK signaling pathway in the KEGG database NLK SAA1 PMC7870784__F5 Model illustrating the miRSNP → miRNA → risk gene → pathway effect PSD IGF1 JAK1 BDNF PSD PMC2707344__F4 Metabolic implication of leaf mitochondria during water stress ATM C6 MAL PMC6762067__F1 Ten simple rules to create biological network figures for communication EGF NDN PRKCZ F2 EGFR NRAS INS APP ARC UBB ARAF SPRY2 PMC6305291__F5 Glucose catabolism pathways and transport systems of strain A4B-17 PTS NONO PMC5842210__F1 Pathogenesis of diabetes and its complications, reflecting where CCN proteins may take part CYR61 CCN5 CCN3 CTGF PMC3372250__F5 The Hsp90 folding cycle STIL CDC37 PPT1 PMC4197103__F1 Necroptotic signaling in adaptive and innate immunity RIPK1 TLR4 TRADD CYLD RIPK3 TNF TRAF2 FADD TLR3 MLKL PMC8967065__F5 Instructive cues establishing PCP during kidney development WNT9B WNT7B PMC4970921__F1 Microarray and bioinformatics analysis of tendon fibroblasts treated with PRP or PPP HEL-S-62p MMP10 PLSCR1 OLFML2B GADD45G MMP9 HEL-S-101 LCN2 SERPINE2 CEBPB CCDC80 MMP3 MSLN ERCC1 PMC8967065__F4 Relationship between PCP and cystogenesis FZD3 VANGL1 PMC8037356__F7 The signaling pathway in tested melanoma cells RICTOR ULK1 HEL-S-28 EIF2A PTEN EIF4E MTOR PMC8406487__F4 6‐Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species NGF CASP2 CAD TNF DIABLO TRAF2 FADD HRK PMC8967065__F3 PCP signaling in kidney development FZD3 PCDHJ PTK7 DCHS1 FZD4 CELSR1 FAT1 ROR1 WDPCP FAT4 RET WNT4 GDNF ROR2 VANGL1 CD2AP FZD8 PMC10385932__F1 Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies ITK EGR1 ATF3 IL2RA JAK3 JAK1 SOCS1 IL2RB PMC5412393__F4 Potential contribution of protein disulfide isomerase (PDI) and various environmental factors in regulation of the TF-fVIIa complex on the surface of epithelial ovarian cancer (EOC) cells TFPI CA9 TF PMC9048014__F5 Candidates for Biomarkers in Bipolar Disorder: A Proteomic Approach through Systems Biology HEL-S-62p F10 TFPI CS PLG CPB2 CD59 PC A2M F2 FH F3 VWF CR2 PMC9182524__F3 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer BAD PTEN HEL-S-68p PMC9182524__F6 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer NOTCH1 CCND1 ADAM10 SOX9 PMC4904147__F1 Antigen processing through MHC I molecules TAP2 B2M TSN PMC3367714__F1 ATM/ATR DNA-damage response pathway WEE1 ATM ATRIP ATR PMC7341754__F6 Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets HNF4A APC CEBPA PMC4868905__F2 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines CXCL8 CCL5 CXCL3 CXCL2 CCL2 TNF PMC10197881__F9 Proposed mechanisms STAT1 CCR2 XAF1 HERC6 PMC4905223__F1 OGT links cancer cell metabolism and cell survival via regulation of HIF-1A OGA OGT HEL-S-133P PMC11575457__F1 [KRAS signaling pathway and targeted therapeutic agents IGF1R GAB2 GAB3 EGFR GRB2 SOS1 MTOR PMC3776465__F2 Functions of the proteins encoded by the genes mutated in primary lymphedema cluster around a central molecular pathway: the VEGFR3 signaling VEGFC FLT4 SOX18 PROX1 FOXC2 CCBE1 KIF11 GATA2 PMC9182524__F7 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer CDK2 MDM2 BCL2 ESD ATR CDK6 BAX PMC9506679__F2 Emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment TRIM21 IRF3 PMC3539252__F3 Upregulated HCV gene signature is enriched for interferon (IFN) pathway genes LY6E OAS3 RSAD2 IRF9 MX2 PMC4443295__F4 Schematic overview of the 7TM receptors judged to be either stimulating (in green to the right) or inhibiting (red or orange to the left and top) ghrelin secretion directly on the ghrelin cell CASR GIPR FFAR2 GIP SCTR RAMP1 PMC5778124__F6 Inhibitory nucleotide-binding oligomerization domain (NOD)-like receptors put the brake on NFKB activation via canonical and non-canonical pathways IRAK1 TRAF3 RELB TRAF6 CD40 MYD88 TNF PMC8638432__F12 Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway HMGA2 GC MTOR PMC4299512__F1 Select upstream regulators and downstream effectors of mTOR signaling TSC2 TSC1 GSK3B PTEN SGK1 RHEB PMC2892366__F10 A model for the function of GCN2, ATF4, ASNS and Asn in conferring tumour cell protection from microenvironment stress SLC1A4 ATF4 ASNS EIF2A PMC5571822__F1 EGFR pathway and mechanism of action of osimertinib.Abbreviation: EGFR, epidermal growth factor receptor; TGF, transforming growth factor EGF JAK1 MTOR TGFA STAT3 PMC6830765__F1 NFKB pathway and the inhibitory effect of various alkyl nitrate N-Aryl Piperamide on NFKB translocation and COX-2 function MYD88 NAPA IL1B PMC5630446__F2 Bladder cancer stem cells: clonal origin and therapeutic perspectives SUFU GLI3 GSK3B SHH PMC8863469__F16 29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses MTR APC PTEN PMC4747503__F5 Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea CS MYO7A PMC7068531__F2 JAK-STAT-3 signaling pathway SOCS3 CCND1 STAT3 PMC3561841__F1 Why stress is BAD for cancer patients BAD MYC PTEN PMC6230580__F2 Snail and cell-cycle progression CCND1 PCNA CCND2 PMC5630446__F4 Bladder cancer stem cells: clonal origin and therapeutic perspectives APC GSK3B PMC12081031__F1 Schematic displaying the unfolded protein response signalling pathway ATF4 XBP1 PMC4639861__F9 Model for Grhl2 function in coordinating differentiation and morphogenesis of airway epithelium MYB ZNF750 RFX2 MCIDAS NOTCH3 FOXJ1 SMAGP PMC11092382__F2 Antitumor effects of sophocarpine through multiple signaling pathways MMP9 PTEN CDH2 MTOR HES1 PMC12081031__F3 The promotion of EMT by XBP1 ZEB2 XBP1 PMC5537069__F6 Schematic representation showing downregulation of miR‐205 by ErbB2 signaling via Ras/Raf/MEK/ERK pathway ERBB2 PMC8959892__F2 Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy TLR4 ARC TXNIP MYD88 SIRT1 PMC4350284__F5 Activated SFK interfere with dimerization and nuclear translocation of pSTAT5A in BCR-ABL expressing cells EPO BCR GAB2 PMC8224095__F1 Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway FYN KEAP1 GSK3B PMC3511450__F5 Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways PRKCZ MAP3K11 RPS6KA4 TRAF6 MYD88 MAP2K6 CRKL PDPK1 PRKCA BTC INPP5D MAPKAPK5 C7 SRC PRKCI MAPKAPK2 IL1A MAP3K1 PRKCQ ERBB3 MAP3K7 MAP3K5 DOCK1 TNF CRK IRS1 TNFRSF1B PRKCB RPS6KA1 TRAF5 TIFA GRB2 MAPK11 PRKCH TGFA IKBKE EGF IKBKG CHUK BRAF MAP2K4 EGFR IL1R2 IL1R1 MAP2K3 MTOR MAP3K15 DAG1 ERBB4 CAMK4 ECSIT IL1B INPPL1 TLR5 MAP3K6 RPS6KA5 MAP2K2 NRG1 MAP3K10 RAC1 IL6 MAP3K13 MAP3K12 IKBKB RPS6KB1 MAP2K1 GAB2 ERBB2 MAP3K2 C6 CD40 MAP3K8 JAK3 IL6ST JAK1 MAPKAPK3 RAF1 TRAF2 STAT3 PMC10239578__F4 Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma RELN BAD ITGB8 NGF PDGFRA MDM2 GRB2 PTEN COL2A1 MTOR FGF9 PMC6698587__F1 Regulating mechanisms of UCA1 in multiple human cancers HMGB1 MMP7 AGO2 FGFR1 ZEB2 RAB22A CREB1 BCL2 SOX4 PMC3303469__F1 Hypoxia inducible factor (HIF) pathway EP300 VHL HIF1A PMC10884928__F1 NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota NAPRT NAMPT HEL-S-90n NADSYN1 NRK PMC3013804__F3 Case study of the discovered phosphorylation networks associated with insulin signaling pathway EGF BAD MAPK8 MAPK7 MAPK14 MYC GCK RAC1 IRS1 INSR PAK1 ERBB2 ZAP70 GRB2 RAF1 JAK1 SOS1 JUN SHC1 CDC42 PMC3562241__F6 Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model IHH RUNX3 RUNX2 PTCH1 SMO PMC10884928__F3 Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity BCKDK NAMPT SIRT1 UCP3 UCP2 PMC4646490__F8 Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway EGF EGFR SRC GAA PMC7896234__F1 Mechanisms underlying microglial response to peripheral inflammation.(A) Schematic representation of the signaling pathway underlying changes in microglial Ca2+signaling, induced by peripheral inflammation NLRP3 TRPM2 IL1B PMC10669501__F2 Interplay of NRF2 in Kupffer cells and HSCs during the progression of chronic liver disease KEAP1 SMAD2 TGFBI PMC5974094__F1 Potential immune mechanism involved in vaccination with G10E-CS CS APC PMC9434901__F9 Oleuropein inhibits invasion of squamous cell carcinoma of the head and neck through TGFB1 signaling pathway SMAD2 SMAD4 PMC9011134__F7 Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway PAK1 BCL2 DKFZp686F0183 BAX PMC11695430__F1 Protein signaling pathway involving both DAMPs and selected cytokines in ICD modulation HMGB1 CXCL10 HEL-S-99n CXCL8 IFNB1 IL6 TNF IL12A IL12B IFNG IL23A IL17A HSPA4 PMC6019623__F2 Synovial cell metabolism and chronic inflammation in rheumatoid arthritis MYC HIF1A MTOR PMC6224991__F1 Axels and brakes in the immune reaction ZAP70 CTLA4 PMC7582690__F2 PI3K/Akt signaling pathway converges to facilitate the progression OS IGF1 CX3CR1 SRC ZIC2 MTOR AXL GPNMB PMC3342049__F2 Autophagy within antigen donor cells and cross-priming APC SYK HEL-S-92n TLR3 PMC6466304__F2 Diagram of major H4K20-related proteins and their proposed role in DNA double stranded break (DSB) repair RNF168 RNF8 FANCD2 MDC1 NSD2 SETD8 KMT5C KMT5B PHF2 PMC4891302__F6 Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer UBE2C MTOR PMC7194552__F4 Phosphatase and tensin homolog (PTEN), a p21-activated kinase (PAK)1 blocker, interferes with coronavirus-induced PAK1-dependent signaling pathway leading to lung fibrosis PAK1 PTEN CCL2 ACE2 PMC11063341__F1 Mechanism of Hippo pathway and the hippo targets of ncRNAs TEAD3 VGLL4 TEAD4 TEAD2 PMC3693466__F1 Insulin Signaling: Inositol Phosphates Get Into the Akt IP6K1 PI3 PTEN IRS1 PMC6767532__F1 Cyclooxygenase (COX) pathway and prostaglandin E2 (PGE2) signaling COX1 PMC6695051__F4 Result of the exploration of HTR1A functions involved in biological process pathways using the STRING database (http://string-db.org/newstring) RICTOR FOXO3A HEL-S-28 HTR1A GSK3B MDM2 PTEN MTOR FOXO1 PMC4202123__F1 Structural basis for cancer treatment decisions EGFR GRB2 PTEN MTOR PMC10041595__F5 NRF1 Regulates the Epithelial Mesenchymal Transition of Breast Cancer by Modulating ROS Homeostasis TJP1 SOX2 HEL113 CDH2 PMC2806370__F3 Pathway deregulation in ovarian cancer RARA SMO ACD PMC4202123__F3 Structural basis for cancer treatment decisions HGF ERBB2 ERBB3 EGFR MTOR PMC6484897__F1 TLR signaling and downstream molecules IRF3 MYD88 TLR1 PMC2806370__F2 Cell cycle pathway gene expression CCNA2 PLK1 GSK3B SMAD4 RB1 CDK6 CCNE1 SMC1A WEE1 MDM2 CDC27 TGFBR3 ANAPC1 ANAPC7 ANAPC11 CDC23 CDKN1B GADD45A CDC20 CDC6 CDK2 APC2 ATR TGFB1 PCNA TGFBR2 CCNH CCND3 PKMYT1 CCND2 CHEK2 ATM TBC1D8 CCNB1 CCND1 CDK4 YWHAG PRKDC PTTG1 RBL1 CCNE2 UBE2F BMP2 SKP1 CHEK1 PTTG2 CCNB3 EP300 BUB1B CCNB2 MPEG1 SKP2 ESPL1 ANAPC10 PMC4264984__F5 Putative mechanism for EGCG-conducted cardioprotection against H2O2-induced oxidative stress through the Akt/GSK-3B /caveolae pathways in cultured H9c2 cells HEL-S-97n CCND1 ENO1 INPP4B SDHA ALDH2 PMC3193288__F1 Innate immunity against RNA viruses in mammals TBK1 IRF3 TLR3 MAVS PMC6773405__F4 Focal adhesion pathway with enriched genes DOCK1, FLNB, FLT1, FYN, IGF1R, PPP1R12A RELN VASP AGA FLNA CHAD PTEN HEL114 PMC6011061__F1 The Keap1/Nrf2 pathway and its epigenetic modification by SFN MAF KEAP1 SFN NQO1 PMC7560597__F5 Complexity of interactions between autophagy machinery and the cGAS–STING pathway TBK1 CGAS ULK1 WIPI2 IRF3 PMC7560597__F4 Interplay between the cGAS–STING signaling pathway and pyroptosis CGAS AIM2 IL1B PMC7560597__F3 Initiation of necroptosis by cGAS–STING signaling RIPK1 RIPK3 TNF IFNAR1 MLKL PMC7560597__F2 Interplay between the cGAS–STING signaling pathway and apoptosis TBK1 CGAS APAF1 IRF3 BAX PMC7560597__F1 Activation of the cGAS–STING signaling pathway to drive innate immune responses TBK1 CGAS IRF3 TNF PMC11091639__F8 PD-L1 regulatory signaling pathway [23] STAT1 TRAF6 PTEN MYD88 PMC8414998__F2 Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance IL10 IL13 IL6 TNF IFNG STAT1 AHR IL2 IL4 CSF1 TGFA IRF4 STAT3 PMC5323854__F7 Putative mechanism of necroptosis in the development of intestinal injury following intestinal I/R HMGB1 TLR4 MLKL PMC3457779__F1 The MAPK cascade activation and potential cross talk signals BAD FYN GRB2 BCL2 JUN FADD BAX PMC4926156__F2 VacA interferes with T-cell activation and proliferation by manipulating the T-cell receptor pathway and the cell cycle FOS LCK JUN LAT PMC7756807__F2 Energy‐generating regulators in Tregs TSC1 MYC PTEN HIF1A FOXP3 PMC9598867__F1 Redox-Regulation in Cancer Stem Cells SOX2 GSK3B VEGFA CD44 GPR49 HMOX1 HEL-S-2a FZD2 SHH CCND1 ASCL2 SMO AXIN2 PMC9537744__F1 Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell transplantation CYP2C19 CYP3A4 GSTM1 PMC12096525__F11 a) LDH-mediated NT3 delivery enhances spinal cord repair: axonal regeneration and functional recovery in a murine model MAP2 PIEZO1 MSC SOX1 CDH2 PMC2806300__F8 Reversal of EMT induced by TGFB1 SMAD2 ZEB2 SMAD4 ARHA PMC9598867__F2 Redox-Regulation in Cancer Stem Cells GSTM2 KEAP1 GCLC GSTM4 ABCC1 GSTM1 SHH GSTM3 HMOX1 NQO1 PMC7291237__F1 Late phase of the HIV-1 replication cycle PC SP2 SP1 PMC10970097__F1 The PI3K/Akt/mTOR signaling pathway BAD TSC1 MDM2 PTEN RHEB PMC3695748__F6 Schema of regulatory mechanisms of endothelial atherosusceptibility discussed in the text VCAM1 KLF4 KLF2 PMC4980327__F1 Molecular alterations cause metabolic switching in cancer cells and severe metabolic changes in the tumor microenvironment TIGAR SCO2 MYC PTEN HIF1A MTOR GLS PMC5992820__F1 Simplified schematic diagram of the pathways described in this study TSC2 TSC1 IGF1R ERBB2 ERBB3 IRS1 PMC4725600__F1 Mdm network and its regulation of p53 activities: a rheostat of cancer risk DKFZp781B1423 MYC MDM2 RAD50 MRE11A PMC3473263__F4 Sample regulation summary diagrams for E CRP GIN1 CP PMC6141435__F1 Hippo signaling pathway in Mammals NF2 AJUBA RASSF6 FAT4 PMC3278889__F6 CD40 signaling to the alternative NFKB pathway TRAF3 RELB CD40 PMC3278889__F5 T-cell receptor (TCR) signaling to NFKB CARD11 PC BCL10 PMC3278889__F4 TLR4 signaling to NFKB TLR4 TRAF6 IRF3 MYD88 MAP3K7IP1 MAL PMC9208314__F1 Translation initiation pathway ELF2 EIF5B ELF5 ELF3 ELF1 SUI1 EIF4B EIF5 PMC8038076__F8 GR-SC65 suppresses the PM-induced ROS-dependent apoptosis pathway APP TRAF6 TRAF2 PMC12222324__F3 FOXM1 involved in chemoresistance in ovarian cancer FOXM1 SP1 MTOR PMC7933973__F1 Current mechanisms underlying KLF5 effects on kidney diseases HEL-S-62p EGR1 YAP1 S100A8 KLF5 CCND1 CDK4 RAC1 LPA S100A9 FBXW7 PMC12222324__F2 FOXM1 in ovarian cancer development PLK1 FOXM1 CCNB1 SMAD4 KIF20A KRT7 KRT5 CDC25B DLX1 SKP2 HK2 PMC2518073__F8 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer TSC2 TSC1 RAF1 IRS1 RHEB PMC10276824__GA FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury FOXO1 PMC8881489__F1 Radiotherapy: Brightness and darkness in the era of immunotherapy HMGB1 CGAS CXCL10 CXCL9 CD80 CXCL11 PMC3683810__F8 Proposed model of p38 MAPK regulation of mRNA translation EEF2K DHH EEF2 EIF5A EIF4E IL1B PMC8555654__F6 Semaphorin3F Drives Dendritic Spine Pruning through Rho-GTPase Signaling TIAM1 ROCK2 LIMK2 PAK1 LIMK1 ROCK1 NRCAM ARHA RAC1 PMC8783172__F4 What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability? TLR7 IRF7 IRAK1 TRAF6 IRF3 MYD88 PMC4017430__F1 Leptin receptor signaling SOCS3 STAT3 PMC8365877__F3 Immunological Involvement of MicroRNAs in the Key Events of Systemic Lupus Erythematosus BCR LYN CD180 CD40 CD80 PTEN CD19 BAX PMC7243768__F2 SARS-CoV-2 enters into the host cell via binding with the cellular receptor ACE-2 CXCL10 APC TRAF3 TRAF6 IRAK4 TIRAP PMC6629926__F1 The role of ARG1 and IDO1 in neoplasia and autoimmunity IDO1 AHR SRC ARG1 PMC9030544__F4 Proteomic Analysis of Endometrial Cancer Tissues from Patients with Type 2 Diabetes Mellitus SPTBN2 ACTN1 PMC8900363__F7 Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway AMH NOBOX EGFR BMP15 SRC FZD4 MTOR PMC2782081__F1 An overview of miRNA biogenesis DGCR8 DICER1 DROSHA RAN PMC3278592__F3 The pleiotropic effects of erythropoietin in infection and inflammation EPOR EPO BCR PMC9138110__F11 Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys HEL-S-182mP PSPH PHGDH CD36 PMC7139589__F3 Extracellular domain consists of five cadherin-type repeats bound together by calcium ions, forming a parallel cadherin dimer EGF EGFR CCND1 PMC5278183__F1 Regulation of Ciliogenesis by Inputs from the Cell Cycle PLK1 KIF24 CEP97 NEK2 MARK4 AURKA PMC5278183__F3 Relationships Between Cellular Proteostasis and Ciliogenesis TSC2 TSC1 BBS4 GSK3B ATG14 DKFZp686F0183 AURKA OFD1 RHEB NDE1 RPGR IFT20 PMC6290922__F5 T-bet: a bridge between innate and adaptive immunity TH CXCR3 RUNX3 CCR3 STAT4 CCR7 CXCR5 KLRG1 MTOR FOXO1 IFNG BCL6 PMC5119679__F1 Hydrogen sulfide (H2S) regulating mesenchymal stem cell (MSC) function RUNX2 MSC TRPV6 TRPV3 PMC5278183__F2 Regulatory Roles of the Cytoskeleton at the Base of the Cilia LIMK2 PLK1 BBS4 SRC ARHA AURKA ABLIM3 PMC3584867__F9 The multiple functions of PE C9 PLG C6 PMC7577940__F1 Mechanosensation SRC LATS1 PMC4707207__F1 PI3K/Akt pathway TSC2 CDKN1B PDK2 GSK3B PTEN BCL2L11 MTOR IRS1 RHEB PMC3636885__F8 STAT3-mediated coincidence detection regulates a noncanonical pathway of IEG induction EGF EGR1 PDK2 EGFR GSK3B GSK3A STAT3 PMC3401455__F2 Rad51 filament formation and regulation RAD52 RAD51 PCNA PMC4985506__F7 The HGF/Met-FOXM1 positive feedback loop HGF FOXM1 CCNB1 CCND1 STAT3 PMC2927346__F1 Irinotecan pharmacogenomics UGT1A3 UGT1A9 CES2 CES1 NFKB1 ABCG2 BCHE ABCC2 ABCB1 UGT1A1 TDP1 PMC3401455__F1 Models for the repair of DNA double-strand breaks RAD52 RAD51 PMC5575202__F5 Significant association of the 97 gene signature with transcription factors TP53 and HIF1A SCG2 PDGFRA FOS ACTA2 HEL-S-101 IGFBP7 HIF1A PALLD IGF1 EGR2 THBS2 TIMP3 DSC3 SEMA3C THBS1 TMEPAI KCNN4 RASSF2 INHBA FGF7 PMC10055176__F8 Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated with Krtcap3 FOXC1 INSIG1 AACS FDFT1 SREBF2 MSX2 BCL2L11 MSMO1 HMGCR TARDBP CP PMC3820561__F1 BRCA1 domain structure and subcellular transport pathways BARD1 BRCA1 PMC8114929__F3 Rhizopine signalling to control PGPR SI PGP ACD PMC3032036__F10 The paracellular pathway in vertebrates and insects PATJ ASIP L1CAM ESAM CRB1 PMC8874090__F4 Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance MAX TDG FAP IGF2 PLOD1 FBN1 HBEGF PTEN PROX1 EZH2 TET2 PMC12024770__F1 STEAP1 protein structure, biological function, and possible carcinogenic regulatory pathway NACA2 EIF4E FOXO1 STAT3 PMC8582580__F3 New Look of EBV LMP1 Signaling Landscape GBP1 TRADD TRAF5 IRF7 RNF31 IRAK1 JAK3 HIF1A TRAF2 IRF4 LIMD1 PMC5907526__F8 Overview of the TLR4 signalling pathway TRAF6 IRF3 IL1B PMC7503766__F7 Nodulation (NOD)-like receptor signaling pathway (PM vs INA TANK APP PMC7662673__F8 Suggested mechanism by which nonanal induces the growth factors expression in DPCs via the cAMP signaling pathway LEF1 IGF1 PMC5176143__F3 Zrf1 controls the temporal expression of the genes related to cardiomyogenesis LEFTY1 NODAL MYOCD CER1 HAND1 DKK1 GATA4 ISL1 BMP4 MESP1 WNT3A TBX5 HAND2 PMC4997077__F1 Oxidative stress and mTORC1-mediated Treg cell differentiation AHR IL6 FOXP3 PMC3136221__F1 “big picture” between DM2 and cancer IGF1R IGF1 MTOR PMC6854381__F6 CMTM7 activates Rab5 which controls the fusion of early endosomes and affects EGFR protein trafficking, an essential part of the PI3K/AKT signaling pathway EGF CMTM7 EGFR PMC5487703__F1 Trypsin-dependent pathological pathway in chronic pancreatitis PRSS1 CTRC SPINK1 PMC9031703__F7 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response APC GRB2 PTEN MTOR IRS1 GTF2F1 PMC4516212__F5 Summary of the inhibitory effects of BSNXD on osteoclast differentiation.Notes: The suppression of BSNXD on RANKL-induced activation of the NFATc1 via ERA pathway is correlated with the inhibition of osteoclastogenesis NFATC1 GRB2 TRAF6 SYK PMC6281418__F7 Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood WNT3A WNT7A WNT1 EGFR MYC AXIN2 JUN PMC5415623__F7 Schematic pathway for low-dose PTX inhibition of cell growth in colorectal carcinoma cells SLC7A11 GLS PMC6146175__F5 STAT 3 signaling pathway and site of action of napabucasin MMP2 IL6 RHO PMC9031703__F6 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response TSC2 TSC1 PDE4A GSK3B GRB2 PTEN MTOR IRS1 RHEB PMC9031703__F5 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response TSC2 TSC1 GSK3B PTEN MTOR IRS1 RHEB PMC6444804__F2 Hypothalamic Lipids and the Regulation of Energy Homeostasis CNTF POMC AgRP UCP2 PMC5326620__F1 Dual functions of IRF3 in antiviral defense TBK1 TRAF3 TRAF6 IRF3 TRAF2 BAX PMC6997700__F1 Leaf lipid pathways and hypotheses for acyl flux into TAG PC LPA PMC6449224__F4 MicroRNAs regulate the smoking‐related ERBB2 signaling pathway EREG EGF NRG3 BAD PAK6 NRG2 MYC SHE CAMK2G HBEGF MTOR CRK CBL PRKCA BTC GRB2 TGFA NRG4 JUN PMC8958685__F6 Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies PCSK9 TLR4 IL6 ABCA1 BAX CD36 PMC7469327__F3 Action of the NLRP3 inflammasome NLRP3 TRPC1 MYD88 PANX1 GSDMD PMC2819006__F1 Key mechanisms involved in colorectal carcinogenesis COX2 APC MSH6 MSH2 PMC5833072__F11 Schematic view of the potential mechanisms by which RNS60 protect motor neurons and ameliorate the neuromuscular impairment in ALS MBP GFAP FOXP3 PMC3331761__F4A Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes PTGIS CS GRB2 HRAS IRS1 PMC3282989__F2 Recapitulation of heart development can provide useful insight for optimizing differentiation protocols NODAL ATF2 GATA4 PMC7439102__F4 Signaling pathway diagram PML ATM GML PTEN ATR PCNA PMC6879940__F1 Proposed mechanisms of podocyte susceptibility to lipid-mediated injury NLRP3 SOAT1 ABCA1 TG CD36 PMC2553712__F1 Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP APAF1 TNF FADD PMC4271318__F8 FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling WNT16 DLD FGFR4 PMC4469999__F2 Complement cascades PMC11634591__F1 CGAS-STING signaling pathway CGAS IRF7 IRF3 PMC4878431__F2 Schema of IR structure and insulin signaling pathways in vascular cells VCAM1 GRB2 INS PMC7400212__F1 In (A): Interactions of methionine cycle, folate cycle, transsulfuration and methylation pathway VIT FPGS PMC10138709__F3 Canonical and non-canonical Wnt signalling ATF2 APC RHO PMC11634591__F4 cGAS-STING pathway in the liver plays a key role in mediating NAFLD/NASH/ALD TBK1 CGAS TLR4 IRF3 PMC11634591__F3 cGAS-STING pathway plays a critical role in mediating obesity in adipose tissue TBK1 PDE3B CGAS TLR4 IRF3 PMC10138709__F5 Hippo pathway and its crosstalk with other signalling pathways NLK AMOT NF2 AREG OGT APC VGLL4 LATS1 RHO LATS2 PMC11634591__F2 cGAS-STING pathway plays a significant role in mediating cardiovascular disease TBK1 CGAS YAP1 TREX1 IRF3 LATS1 LATS2 GSDMD ALDH2 PMC8103724__F1 Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion ULK1 ATG12 ATG3 ULK2 STX17 MTOR VAMP8 ATG14 SNAP29 MLST8 PMC7395311__F3 Cytokine and receptor Janus kinase pathway CNTF CLC EPO LIF TPO IL24 TYK2 JAK3 JAK1 TSLP OSM PMC3898671__F2 Synthesis of the C5 isoprenoid precursors IPP and DMAPP MVD IDI1 IPP PMC11187367__F6 Summary of the findings IL18 CD163 PROC CD44 IL8RB GDF10 CXCL12 TNF CD74 GRP CYTL1 PMC10138709__F2 Hedgehog signalling pathway SOX2 SUFU PTCH1 MYC SHH SMO PMC3530456__F5 Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis PLSCR1 RAET1E MPPED2 PFKM SLC26A4 CEBPB CCR1 IGSF6 LINGO2 FGFR1 IKZF1 LILRB4 TYRP1 PEG10 GJB2 FURIN MSX2 AXL PLXDC2 GPNMB RUNX3 FBP1 KCNJ12 PSAP FGF18 NNAT PLCB4 KCNC4 TNFSF10 CLEC4A LILRB3 DMBT1 TXNIP NRN1 FRAT1 CTNND2 BCAS1 PMC3520539__F1 Generalized overview of the regulation of apoptosis by sphingolipids BAD CASP9 PMC7280066__F1 Regulatory functions of oncogenic and tumor suppressor long non-coding RNAs (lncRNAs) in the Wnt/Beta-catenin signaling pathway attributed to the pathogenesis of non-small cell lung cancer (NSCLC) SOX2 APC DKK1 SOX9 SOX4 PMC9503946__F10 Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library RIPK1 CXCL8 TRIM25 MAVS CP PMC4300866__F2 Three pathways of complement activation: classical, lectin, and alternative pathways HEL-S-62p C4B_2 MASP1 C7 C6 MASP2 C1S C4A PMC8603497__F4 Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense MVD MVK IPP PMC3041769__F4 Antibodies against CD20 or B-Cell Receptor Induce Similar Transcription Patterns in Human Lymphoma Cell Lines DAPP1 VASP SCARB1 BCL2A1 HMMR RTKN CREM BCL2 DDB2 SRGN PMC4300866__F1 Biological functions of the complement system HEL-S-62p C9 C4B_2 BCR CR2 CR1 PMC8957965__F8 Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control PINK1 TFAM CYP2E1 PMC8842603__F1 Tankyrase Inhibitor for Cardiac Tissue Regeneration: an In-silico Approach APC LRP5 LRP6 TNKS PMC9319717__F2 Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis SOCS3 APC IL31 IL4 SOCS5 SOCS1 PMC8671096__F2 Construction of synthetic microbial consortia for 2-keto-L-gulonic acid biosynthesis PDX1 GOT2 PFKL ARG1 MDH2 PMC5678971__F1 ULK/Atg1 redirects machinery used under vegetative conditions for stress-induced autophagy SEC16A ATG101 ULK2 PMC7525161__F7 Identified key pathways HP ND1 LIF CAD PMC8416724__F3 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy SIRPA CGAS CD47 IRF3 PMC9534575__F2 Quaternary ammonium compounds in hypersensitivity reactions TH IL4 TSLP PMC2686461__F1 BCR signaling pathway BCR CSK CD22 LYN PAG1 PMC8416724__F2 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy SIRPA CD47 SET QPCTL MYC HEL-S-92n TCF4 PMC8103321__F1 APC Promoter Methylation in Gastrointestinal Cancer USF1 CDX2 CEBPZ USF2 APC GSK3B YY1 ARC EZH2 PMC12025301__F1 Ferroptosis signaling pathway GPX4 LPCAT3 STEAP3 FACL4 HEL-S-64p ALOX15 FTL CP PMC3178610__F5 Determining Signalling Nodes for Apoptosis by a Genetic High-Throughput Screen NFKBIA EGR1 ATP1A1 CCL13 GNAS TNF PMC4536022__F2 Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNFA or IGF1 CCNA2 MYBL2 PLK1 CREB1 CHEK1 CDK6 CCND2 CDKN1A CDC6 WEE1 CCNB1 CCND1 CDC2 TRIM28 CDT1 ELF4 MKI67 SLBP PMC6302218__F2 Autophagy and the inflammasome NLRP3 IL16 IL1B PMC5264637__F1 Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom ADA GLA PMC9637147__F1 Molecular mechanisms of ferroptosis SLC48A1 GPX4 LPCAT3 SLC7A11 DPP4 ADFP GLS2 TFRC POR FLVCR2 HMOX1 SLC46A1 HMGCR HEL-75 SLC3A2 OGDH ABCA1 DHODH SLC11A2 PMC9105255__F6 Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia SI IMPACT PMC6977534__F2 Roles of zinc transporters in B cells of different stages BCR LYN SLC39A10 PMC515251__F1 A minimal metabolism PTS HEL-S-5 PMC4399033__F1 Pyrimidine synthesis and salvage pathways in Toxoplasma gondii UPRT OMP DHODH PMC3198893__F5 One of the networks of genes strongly induced in dendritic cells but less so, unchanged, or suppressed in macrophages PPM1J HNF4A MC2R FSHR RNF4 PPP1R10 TRAF2 EWSR1 PMC3198893__F4 One of the networks of genes commonly induced in both dendritic cells and macrophages when infected by bacteria, in both human and mouse PLSCR1 ABCC3 MARCKS KLF6 PMC3811010__F3 Target genes of CDX1 and CDX2, and the BMP/TGFB signaling pathway BAMBI CLDN2 E2F3 MMP7 BMPR2 POMC NR1i1 TEX2 SLC2A2 HEL-S-11 SI ATOH1 UGT1A10 JUNB FURIN UGT1A8 CCL25 LAMC2 DLX2 AKAP12 BMP1 ACTG2 HOXA9 G6PC2 LYZ APC UGDH HBEGF ENG RGS12 ACAT2 APOB ITGB4 CAPN9 NR2F6 KLF4 CDX1 TGFB1 PCNA FABP1 DHRS9 LYPLA1 HLA-G ACVRL1 ZNF483 RUNX2 GPA33 NODAL RETNLB S100G ZNF382 TGFBR1 INS HEL-S-116 NOTCH3 CLU CCND2 FST TLX2 CCND1 PYY NEUROD1 HOXA10 TFF3 JUN GABARAP IL2RB TWSG1 SCT GUCY2C DTX1 NR0B2 NTS BMP7 SPDEF MUC2 ID1 CCK NEUROG3 HEPH CDX2 NBL1 SOX10 SMAD1 CDH17 ALPI TGFBI PMC8416724__F4 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy SIRPA CD47 HEL-S-92n PMC6714138__F8 Schematic diagram showing the cardioprotective effects of YWPC on DOX‐induced cardiotoxicity GCLM KEAP1 BCL2 TGFB1 NQO1 PMC4338835__F3 The catecholamine system in health and disease —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes— SPR TH PNMT DBH PMC6160678__F6 An comprehesive metabolomics and transcriptomics study to identify metabolic pathway alterations in CFG treatment of ovarian tumor-bearing mice in vivo LALBA ACADL SCD ACADS B4GALT1 PMC7469327__F6 Drugs targeting inflammasome signaling in MS and EAE STAT1 NLRP3 NLRP1 IL1B STAT3 PMC9165361__F1 Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits BDNF RGS14 PMC6364417__F7 Pathways affected by the combined selected kinase inhibitors in BRAF mutant melanoma cells WEE1 DES CDK4 PMC3528378__F3 Mechanism of muscle protein synthesis inhibition by GCs IGF1 EIF4E MTOR PMC9455514__F4 Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer OGT ZEB2 CCNB1 LTBP2 CD44 CCND1 ARHA BMI1 PCGF6 PTEN PCGF1 CCND2 PMC5531360__F3 Possible interactions between signaling molecules EPO FGF2 VWF ARHA PMC7388835__F6 Gene interaction network map MERP1 DUS2 MAPK3 RAZ1 LEPROTL1 PRPF40A TCEAL9 ERF RHO TIMCC TNKS2 RERE MRPS16 NF2 DNPEP HNRNPUL1 ENY2 MYRF RBFOX2 ACTR3 SERTAD2 PMC7388835__F5 Network diagram representing the regulatory effects with top consistency scores STAT1 CHUK IKBKG RIPK2 PMC4076091__F7 GW1516 intervention inhibits progression of hepatic steatosis in mice INSIG1 PCK1 CPT1A FASN PMC6548416__F2 Impact of diet-derived signaling molecules on human cognition EGF BAD MAP2K1 PRRT2 RAF1 HRAS MTOR JUN PMC8537973__F9 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations PIK3R1 EIF4A1 ACTA2 MAPK3 TRIB3 EIF2B3 RPL13 EIF2AK2 RPL9 RPS26 PDPK1 PPP1R15A RPL11 AGO1 RPS5 RPS4Y1 ATF4 CCND1 RPL26 RPL3 HEL-S-89n RPL38 RPL6 EIF4E RPS27L HRAS DDIT3 PS1TP5BP1 RPL39 EIF3C PIK3C2B RPL17 RPL28 AAG1 EIF3S3 PIK3R2 PMC7071696__F7 Mechanism graph of the regulatory network of miR-495/HOXC6/TGFB in the progression of OSCC TGFBR1 SMAD4 HOXC6 PMC6082538__F6 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms PES1 GDA SIT1 C6 ECE1 GPD1 PMC6082538__F4 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms GAL HEL60 ALPI MAPDA PMC6972508__F2 Mode of action of thalidomide and its derivatives in regulating host inflammatory response IL2 IKZF3 IL1B PMC4629506__F1 TLR and NFKB signaling disrupted by PID TBK1 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TAB3 PMC4046566__F2 Application of the algorithm to identify TNBC-associated genes PLK1 MED24 NASP KIF1A CENPE NOS1AP RCC1 CIT BNIPL HMGA1 RARA RARB SH3GL3 GABBR2 ERBB2 SIX3 BCL2 ROBO1 HEL113 CCL18 MED1 FANCA NPAS2 GATA3 PMC7803563__F1 Schematic model showing that the DEGs in the older melanoma patients by recurrence status converge at the Wnt signaling pathway FOS PTGS2 IL1B PMC11999469__F8 Connection of Nrf2, NFKB, NLRP3 Pathways and the mechanism of SA GCLM TLR4 KEAP1 RBX1 NQO1 PMC8327141__F4 The MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation MCTS1 SRC ARHA PTEN PMC7368990__F6 Schematics of glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway showing changes at the translational level of enzymes involved in the different steps TIGAR FBP2 CS FBP1 HEL-S-162eP F2 FH HEL-S-304 RPIA OGDH ACLY HEL107 RPE GLS PMC7272692__F4 Mitotic/endocycle switch MYB WEE1 CDK2 TTK DAP CDC2 MYT1 PMC4354340__F8 miR-4689 regulates EGFR signaling pathway EGFR PMC9437264__F12 CGMP/Akt/GSK-3B signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing VASP GSK3B PGC PMC10648128__F5 DEGs belonging to the gap junction signaling pathway in the hippocampus (magenta) and frontal cortex (red) of OXYS rats at PND3 and PND10 PIR CA3 LAT PMC3508723__F8 Model of Tat/Beta-catenin interaction in astrocytes AXIN2 IFNG PMC5259746__F3 Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway TH BAD AIP IGF1R ARHA TNF EDC3 IGF1 GRB2 BCL2 SRPK2 TRAF2 BAX PMC3574110__F4 Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice CTH BHLHB2 ADAMTS2 GPC1 AIP THBS2 BMP2 ADFP BDH1 ATF3 CP PMC10940631__F3 Compensatory relationship between the ubiquitin‒proteasome pathway and the autolysosome pathway ULK1 CDKN1A CCND1 PMC3356354__F8 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes CD14 TLR4 RP1 LBP CD40 MYD88 TNF MTOR MAP3K7IP1 TIRAP PMC3926670__F4 Enriched pathway of the target gene union of radiation-response miRNAs BAD CDK2 BCL2 PTEN MTOR NKX3-1 PMC3356354__F9 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes BTK BCL10 BASH CD22 LYN GRB2 SYK CD19 PMC5643010__F2 Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease SMAD2 SMAD4 PMC4152115__F5 Plausible molecular mechanism of migration and osteogenic differentiation of BMSCs by Ce through Smad1/5/8 signaling pathway BMPR2 RUNX2 BMP2 SMAD1 DKFZp781O1323 PMC12152576__F2 Contribution of type-I IFN-mediated neuroinflammation to Parkinson's disease progression STAT1 CGAS STAT2 IRF7 IRF9 IRF3 TYK2 IFNAR2 JAK1 IFNAR1 PMC10216802__F2 LPS (TLR4)-mediated inflammation and its interplay with RhoA activation and the downstream ROCK signaling pathways ROCK2 TLR4 ROCK1 ARHA TNF PMC6545862__F1 A potential nuclear factorKB activation pathway obtained by RNA-sequencing analysis in canine diffuse large B-cell lymphomas IKBKG TLR9 TRAF6 PLCG2 MYD88 MTOR BLK CD79A NFKBIA BTK CARD11 BCL10 BASH RELA LYN SRC SYK CSA2 TNFAIP3 CD19 PMC4163606__F1 LIF signaling and post-translational modifications of some stemness transcription factors SOX2 SOCS3 LIF KLF5 SUMO1 STAT3 PMC2536868__F7 Pathways for major lipid metabolism SQLE DGAT1 PMVK PC FADS2 AACS AGPAT3 FDPS FADS1 CRAT ACLY GPAM PMC9355246__F2 Regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling ULK1 PTEN EIF4E MTOR DEPTOR SGK1 RHEB MLST8 PMC5652964__F6 Proposed working model of ZZR on the Hedgehog signaling pathway-mediated MDR in colorectal cancer cells SUFU PTCH1 GLI3 SMO PMC6562634__F3 Schematic model of regulation of the Hippo pathway by numerous signaling pathways in cancer PAK1 MUSK LRP4 NF2 HEL-S-28 LATS1 LATS2 PMC6562634__F2 The Hippo pathway drives fibrosis across the organs NF2 LATS1 LATS2 PMC6562634__F1 The Hippo pathway in the pathogenesis of tissue fibrosis IHH ACTA2 SMAD2 SNAI2 LATS1 LATS2 TTF1 FJX1 INHBA PMC11245093__F4 Genomics-based reconstruction of pathways involved in the utilization of monosaccharide derivatives FRK NAGA MIP RPE PMC5025072__F5 Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer SOST MYC SPRY1 IFNG STAT1 PIM1 PIAS2 SPRED3 SOCS7 PTPN11 STAM2 PTPN6 SPRY4 SOS2 IRF9 SPRED1 THPO SPRY2 CBL IL15 LEP CREBBP EP300 CISH GRB2 PIK3CA JAK1 CBLC AKT3 PMC6695454__F3 Therapies targeting p53 functions MDM2 PRIMA1 BAX PMC3504715__F8 Cytokine-induced CITED2/MYC/E2F3/p21CIP1signaling in lung cancer EGFR TGFBR1 MYC SP1 TGFA HDAC1 E2F3 CITED2 PMC6562634__F4 YAP/TAZ-mediated regulatory networks in cancer SOX2 FOXM1 FSTL1 SNAI2 FGFR4 DKK1 SLIT2 FGFR2 SOX9 FGFR1 TBX5 CCND1 HEL113 THBS1 CDC2 COIL AXL SKP2 PMC8465517__F2 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease ATF4 EIF2A ARF4 CREB3 TF PMC3844829__F3 Metacore™ apoptosis signaling pathway relating to mitochondrial proteins BAD IGF1 TNF HRK BAX PMC3844829__F2 Metacore™ apoptosis signaling pathway relating to TNF receptors, NFkB and BCL-2 antiapoptotic family genes TNFRSF21 TNFRSF18 TNFRSF10A FADD PMC1323499__F1 New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor TLR7 TLR4 IRF3 MYD88 TLR3 PMC8465517__F4 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease ATF4 EIF2A SP1 PMC3844829__F4 Metacore™ apoptosis signaling pathway relating to caspase activation RS1 IGF1 CAD PMC5908886__F3 Peroxisome proliferator-activated receptor gamma (PPARG) activation COX2 BAD PTEN TNF BAX PMC5908886__F4 Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/Beta-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis APC LRP5 LRP6 PMC9324774__F1 Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway KEAP1 GSK3B RBX1 PMC6003829__F8 R-loops cause genomic instability in Wiskott-Aldrich syndrome Thelper lymphocytes TH ATM CDK9 PMC11879902__F4 Diagram of glycolytic signaling pathway in senescent cells TIGAR MYC MDM2 IRS1 HEL-S-133P HK2 PMC11879902__F3 Aerobic glycolysis in tumor cells TIGAR FOXC2 HEL-S-133P HK2 PMC12246557__F5 Type I, type II, and type III interferon signaling and IFN‐I pathway‐related inhibitors STAT1 STAT2 IRF9 TYK2 JAK1 PMC5826217__F1 Insulin/IGF-1/PI3K/Akt/GSK3B/tau signaling IGF1R IGF1 GSK3B IRS1 PMC9275048__F2 Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis PIK3R1 MAPK9 SOCS3 SMAD2 SOST NRAS AKT1S1 PLCG2 IL6R OSMR CYP27A1 FGFR1 FLT1 LPL DVL2 IFNGR1 IL10RA NTRK2 ITGB3 SOS2 LRP6 GNA13 FZD4 THBS4 IL10RB SHC2 PIK3R5 PLCB2 PPP2R3B IL2RG IL11RA ACTG1 AKT3 CD36 PLCG1 TGFBR1 TGFBR2 COL1A1 NOTCH3 RXRB TLN2 opn VWF KITLG SFRP1 THBS1 FGF7 ITGA1 NOTCH4 ARHA RAC1 LTBP1 PTPRF PS1TP5BP1 IKBKB CPT1A ERBB2 LYN SLC27A1 SYK CSF1 WNT5B PPARG ACSL3 SHC1 COL4A2 COL4A1 PHLPP1 PIK3CD IL3RA EFNA1 FACL4 CRKL SCD ACSL1 COL6A1 SRC PCK2 NOTCH2 SFRP4 VEGFA LAMB2 IFNAR2 CACNB3 IFNAR1 FERMT3 HRAS CRK LAMA3 RXRA TNC ITGB4 THBS2 THBS3 GRB2 CHAD ITGAV COMP SIRT1 CACNB1 CDC42 PLCB3 IKBKG CHUK IL13RA1 EGFR CSF3R TLN1 IFNGR2 ITGA7 CSF2RB MTOR HEL-S-104 RPTOR INSR PDGFD NGFR PTPN1 PLCE1 COL1A2 NR1H3 XB PLCD3 ADIPOR1 ADIPOR2 SV2B SLC27A4 PF4 FGF2 SMAD6 CD44 ITGB1 DVL3 DVL1 PDGFC LAMB1 PIK3CA VEGFB PIK3R2 PMC5922346__F6 Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation TBK1 IRF3 TYK2 MLKL PMC8763513__F10 3B,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy NLRP3 IL16 TXNIP MTOR PMC12246557__F3 Nucleic acid sensors and downstream signaling pathways induce type I IFN production STAT2 IRF7 IRAK1 IRF9 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR8 PDC TLR7 TYK2 PMC3471537__F1 HER2 activation EGFR GRB2 PTEN PMC11996656__F3 Signaling pathways involved in the pathophysiological development of OA, along with their corresponding targeted therapeutic drugs HMGB1 CMPK2 SMAD2 GBP5 TRAF6 MYD88 USP25 MTOR METRNL GSDMD STAT1 NLRP3 TLR4 OGT TXNIP IRF-1 PMC11996656__F2 Pyroptosis in OA pathogenesis NLRP3 HMGB1 GSDMD PMC11996656__F1 Classical, non-classical, and other pathways involved in pyroptosis NLRP3 IL1B GSDMD DFNA5 PMC2180420__F9 Co-coculture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells FYN EGFR GRB2 PMC6026536__F1 Reactions and enzymes of proline metabolism in higher organisms PYCR2 PRODH PMC3087811__F8 Schematic model for the role of TGFB signaling pathways in iTreg and Th17 cell development TGFBR3 FOXP3 PMC4702573__F6 Simplified model for CCC DNA synthesis and innate immune induction by HBV in AML12HBV10 cells TBK1 CGAS IRF3 PMC2943859__F9 TNF-R1 signaling pathways GADD45B TRADD TRAF1 TRAF2 FADD PMC8778078__F3 Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging NLRP3 IL18 IL1B PMC2949723__F3 Eicosanoid signaling pathway from Ingenuity Pathway Analysis software ALOX15 ALOX5AP ALOX5 PMC8755999__F1 Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management FDX1 CYP11A1 HSD3B2 SRD5A2 POR CYP17A1 CYP21A2 STAR CYP11B2 FDXR PMC5350732__F3 Gene transcripts associated with sensitivity to gefitinib and EGFR and/or head and neck cancer, identified from the genome‐wide statistical analysis, followed by pathway analysis EGFR EFNB2 TGFBR1 S100A2 FBN1 SMAD4 FYN NR1B3 TIMP3 KRT13 PTPN6 LY6D LAMC2 KRT16 ELF1 AREG CD82 FGF2 ADRB2 CCNL1 GRB7 HEL-S-22 CSTA RASSF1 ELF3 RELA SCCA2 CTNND1 HEL113 TGFA SERPINB3 ARNT2 PMC9084610__F1 COVID-19 Infection During Pregnancy Induces Differential Gene Expression in Human Cord Blood Cells From Term Neonates ADAM10 CRTC2 FOXO1 PMC4133771__F1 Possible signaling of G SEMA3A GSK3B GSK3A DCC BDNF PMC6378068__F5 GPL pathway constructed in this study EGF COX2 BAD TRADD ERBB2 EGFR RAN RXRA PMC4768116__F2 Activation of nuclear factorKB: Canonical and non-canonical pathways TLR4 BCL10 BCR RELA RELB CD40 PMC8517843__F3 ADAMs family in kidney physiology and pathology CXCL16 EGFR NOX4 ACE2 PMC5665066__F1 PolyI:C induces tumor necroptosis via the TLR3 -TICAM1 pathway TBK1 IRF3 TLR3 MAVS MLKL TICAM1 PMC4745409__F2 Pathways involved in internalization and sensing of dsDNA TBK1 HMGB1 IL16 TLR9 BCR IRF7 TRAF3 TRAF6 IRF3 MYD88 AIM2 MAVS PMC6760864__F3 New insights into cytoskeletal remodeling during platelet production HEL-S-52 ARHA PACSIN2 CDC42 PMC2480606__F2 NFKB pathway in skeletal muscles CCND1 YY1 BAX PMC11807217__F8 Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis HEL-S-28 NR1C2 CDK4 TF CDK6 BAX PMC9024148__F6 Multi-Omics Characterizes the Effects and Mechanisms of CD1d in Nonalcoholic Fatty Liver Disease Development PDE4D APOA4 FADS2 GSTM3 AMY1A CYP1A2 ADM HEL-S-22 PMC2816026__F7 Met signal transduction exploited by InlB from L FYN NEK9 CBL PMC8112564__F6 ANKRD22 enhances breast cancer cell malignancy by activating the Wnt/Beta-catenin pathway via modulating NuSAP1 expression NUSAP1 ANKRD22 PMC2480606__F1 An outline of major signaling pathways leading to NFKB activation BCL10 TRADD ATM RELB TRAF6 MYD88 MAP3K7IP1 TRAF2 LTBR PMC8607246__F2 A novel potentially transforming somatic mutation in CSF2RB gene in breast cancer IL3 CSF2RB MTOR CSF2RA STAT3 PMC8287856__F1 Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution MMP7 SMAD2 SHH MTOR THY1 PMC5003773__F1 Empowering Regulatory T Cells in Autoimmunity RBPJ PTEN FOXO1 FOXP3 PMC3035137__F2 Effects of Hfe deficiency and the associated low hepcidin and intracellular iron levels on macrophage TLR4 signaling TLR4 HFE MYD88 TLR3 MAL PMC8777499__F1 Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer MTHFD2L PSAT1 SHMT1 PSPH MTHFD1 HEL-S-51e MTHFD2 PHGDH PMC7767764__F1 Lipofuscin and drusen in the RPE RDH8 ATR RPE PMC9050318__F6 Mechanism of Osthole in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking Technology TRAPPC3 BCL2L1 TNF PMC8870390__F1 Precision Targets for Intercepting the Lethal Progression of Prostate Cancer: Potential Avenues for Personalized Therapy PTEN JAK1 IL6R STAT3 PMC6086630__F7 Network mappings were Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of HOXA3 co-expression genes in NSCLC PDGFD DCN CDKN2B PPARGC1A EGFR GLI3 EVI1 PRKD2 NKX3-1 INHBA MYLK AKT3 PMC3903560__F7 Ingenuity pathways analysis MAP3K1 APOL3 HAVCR2 NFE2L3 CD84 CARD16 IL18BP APOL1 PMC8903057__F4 Diverging effects of LMW-HA and HMW-HA in neurodegeneration and AD TLR4 CD44 HAS1 PMC7934812__F1 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation TLR4 TRAF3 TRAF6 IRF3 MYD88 TIRAP PMC3613823__F8 The proposed therapeutic mechanism of caspase-7 ablation in ADRP T17M RHO retinas F8 ATF4 RHO HIF1A MTOR PMC4839461__F1 Schematic overview of de novo and salvage dNTP biosynthetic pathways and the mechanism of action of dCK-dependent nucleoside analog prodrugs ADA PNP PMC3193407__F1 NFKB activation by the canonical pathway EGF EGFR LPA PMC7934812__F2 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation TLR4 TRAF6 IRF3 MYD88 IL1B TIRAP PMC12116171__F3 Up-regulated circadian rhythm pathway and phenological effects of cul4 mutant PRR9 ELF3 PRR7 PRR3 PMC5805723__F7 Oncogenic cooperation of BRAF V600E and TERT promoter mutations FOS MYC TERT PMC10372325__F6 Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats PML BHLHB2 SP2 NFE2L2 CEBPA CEBPB GATA4 FOXP3 BATF UBTF EP300 NOTCH1 JUND JUNB IRF-1 TCF4 PMC8879755__F2 Innate Immunity in Mucopolysaccharide Diseases NLRP3 TLR4 GFAP TNF IL1B PMC10217168__F14 Graphical summary of the protective effect of Lactiplantibacillus plantarum Lac16 against enterohemorrhagic E TH TLR4 CCND1 FZD7 TRAF6 MYD88 AXIN2 BAX PMC5487892__F3 DNA substrates and protein factors required for S-phase checkpoint activation MRC1 POLE RAD17 ETAA1 DNA2 PCNA CDC45 PMC5645256__F2 Association between expression of cell cycle proteins in NETs according to pathway CDKN1A CDK2 CDKN1B CCND1 CDK4 CDKN2A CDK6 CCNE1 PMC8509327__SF3 Non-Canonical Wnt Signalling Pathways in Bone Biology NLK ATF2 LRP5 TRAF6 LRP6 ARHA ROR2 MTOR PMC5443707__F1 Coordination of DNA Single Strand Break Repair FEN1 PARP1 LIG1 OGG1 PCNA PMC4800996__F2 Serine biosynthesis and utilization PSAT1 SHMT1 PSPH GLDC HEL-S-51e PHGDH PMC8509327__SF2 Non-Canonical Wnt Signalling Pathways in Bone Biology ARHA ROR2 RAC1 CDC42 PMC8509327__SF1 Non-Canonical Wnt Signalling Pathways in Bone Biology APC LRP5 LRP6 ROR2 BCL9 PMC3913524__F1 The PI3K/Akt/mTOR pathway substrates and associated cellular functions TSC2 RICTOR PTEN EIF4E MTOR RHEB PMC3607121__F1 Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer HSD3B1 AKR1C1 CYP7B1 HSD17B2 HSD17B3 AKR1C2 UGT2B15 HSD17B6 PMC10525295__F1 Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia HEL-S-62p SCD FH PMC3890879__F8 Model of mevalonate and Hippo pathways regulating YAP-controlled RHAMM transcription and cancer cell motility ARHA LATS1 LATS2 PMC8122612__F4 Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus NPB HBM ALB ZNF491 HEL-S-47e PLEKHG6 MBL2 MUC7 F13B LY6G6C AMY2B FOV JCHAIN FABP5 PMC8734249__F2 CD70-CD27 axis in oncology: the new kids on the block SOX2 CD27 TNLG8A CD44 HEL113 PMC8734249__F1 CD70-CD27 axis in oncology: the new kids on the block CD27 TNLG8A TRAF2 PMC7691336__F9 Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling NFATC4 RYR2 GATA4 PMC3461086__F3 Canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC11755046__F9 Synergy between the LINC01419/miR-8070/RAD51AP1 axis and HBV in HBV-associated HCC RAD51AP1 PMC8628653__F1 Disruption of the Diurnal Cortisol Hormone Pattern by Pesticide Use in a Longitudinal Study of Farmers in Thailand CYP11A1 CYP17A1 CYP21A2 STAR CYP11B2 PMC3461086__F4 Simplified diagram of signal pathway convergence at downstream nuclear targets RUNX2 SMAD4 SOX9 PMC7327974__F3 A) A model depicting the regulation of apoptosis through the TNF pathway and B) Simulation of the signaling process EGF BAD KDR EGFR VEGFA TNF MTOR CYCS BAX PMC3016890__F1 The p38MAPKsignalling pathway STAT1 MAX ATF2 CCND1 CCND3 MEF2C MX2 CDC42 PMC6535827__F3 Neuroprotective effects of resveratrol in AD COX2 GPX1 BAX PMC8935233__F8 PROX1 promotes breast cancer invasion and metastasis through WNT/Beta-catenin pathway via interacting with hnRNPK ZNRF3 APC GSK3B WAS PROX1 PMC6708252__F1 Interactions between VHL, HIF and the NFKB signaling pathway EGF VHL TNF PMC5458139__F5 Mutational Signatures in Breast Cancer: The Problem at the DNA Level UNG PMC5912715__F3 Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation PTGIS LTA PTGS2 GYPE LTC4S PIGS PTGS1 PMC7186480__F7 Possible cross-talk of IFNs and the AIM2 inflammasome pathways in AMs from TB patients (AMTB) modulated by M STAT1 CD14 IFIT3 TLR4 STAT2 TRAF6 MYD88 AIM2 IRF-1 IFNG PMC7363763__F2 Endothelial cilium regulates various signaling pathways involved in the vascular barrier, such as HH and Notch pathways SUFU DLL4 PTCH1 GPR161 EVC SHH NOTCH1 SMO PMC4463188__F7 MEL-18 loss mediates estrogen receptor–A downregulation and hormone independence PRC1 SENP1 SP1 PMC1766317__F5 Model: A similar CARMA-Bcl10-MALT1 signaling pathway mediates NFKB activation in response to antigen receptor stimulation in lymphocytes and AT1R stimulation in liver cells BCL10 IL1B PMC5655777__F2 This schematic diagram depicts the signaling pathways that possibly drive BAVM pathology SMAD2 SMAD4 PMC4333762__F3 PRb/E2F pathway regulates cell cycle progression E2F4 E2F7 E2F6 CDK2 E2F2 E2F5 CDK4 E2F3 PMC6649605__F8 Proposed mechanism by which gremlin regulates EMT and ECM protein expression in LECs SMAD2 SMAD4 SMAD1 DKFZp781O1323 PMC3589762__F2 Pathways regulating intestinal sterol absorption and homeostasis ABCG5 NPC1L1 ABCA1 MTTP CD36 ACAT2 PMC6284860__F1 p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1 MYB BTK BCR BASH CD22 LYN MYC SYK PLCG2 PTEN CD19 PMC6511523__F4 Molecular biological features in the adrenal gland of Hatano rats MC2R PRL PMC2846156__F3 Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer TBK1 BTK TLR4 IRF7 TRAF3 TRAF6 IRF3 FADD MAL PMC9058298__F6 Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53‐dependent signaling pathway ATM CCND1 ATR PMC8745478__F2 P38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer ATF2 CDC25B BAX GATA2 PMC3989185__F8 Stiffness-Activated GEF-H1 Expression Exacerbates LPS-Induced Lung Inflammation RHO PMC8368762__F1 Pyroptosis in cardiovascular pathologies: Role of noncoding RNAs NLRP3 RIPK1 GPX4 IL18 TRADD IL33 RIPK3 TNF MTOR FADD MLKL PMC9653341__F3 Immune response associated with ischemia and reperfusion injury during organ transplantation CCL17 NOTCH1 CCL22 PMC5713646__F1 Chemical synthesis of n-butyraldehyde from petrochemical feedstock HBD PMC5126119__F2 TLR-4/LPS signaling pathway activated by LPS in ALD CD14 EGR1 IRAK1 LBP TRAF6 IRF3 IRAK4 MYD88 PMC4146087__F5 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder SST BDNF PMC4146087__F1 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder GRB2 SHE BDNF PMC4146087__F2 Interaction of drug and signaling pathway in relevance to depression.Sex steroid hormones serve as an example BDNF PMC11004986__F8 Autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress LPA BDNF SYP PMC6131826__F6 Phosphatidylinositol signaling pathway PI3 PTEN TK1 PMC2737000__F4 TNF-induced NFKB and apoptosis pathways CSNK2A2 TRADD GSK3B TNF CDKN2A BCL2L2 PRKCA IKBKB BIRC2 RELA BNIP3L MCL1 TNFRSF10B TRAF2 FADD PMC5449392__F6 Proposed role of ARRB1, CALM3, FLNA and HTT in OSCC FLNA HTT RALA RAC1 TRIO PMC4382460__F2 IL-10 signaling pathways in normal and abnormal conditions TYK2 CD80 JAK1 STAT3 PMC5382327__F1 Fish retinoic acid‐inducible gene I (RIG‐I) ‐like receptor (RLR) ‐mediated signalling pathways in response to viral and bacterial infections TBK1 RSAD2 IRF7 TRAF3 IRF3 NOD2 MAVS PMC8431390__F1 Nucleic Acid Sensing in the Tumor Vasculature CGAS TREX1 MAVS PMC5352102__F2 Sirtuins in glucose and lipid metabolism SIRT4 SIRT6 PMC5839385__F4 TAM pathway signaling in innate immune cells SOCS3 FOS TRAF3 TRAF6 IRF3 MYD88 ADAM17 STAT1 GRB2 RAF1 JUN SOCS1 MAL PMC4770763__F3 Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies ENO3 HEL-S-30 HEL-S-25 DGKD FBP1 AGK PTGES GPX8 HEL-S-87p PNLIP COX2 GPAT2 LPL ENO2 HEL107 PGAM2 ALDH2 PMC7309569__F3 The dolichol-linked oligosaccharide (DLO) biosynthesis pathway ALG1 ALG3 ALG6 PMC11665856__F7 A working model of PFOA stimulation of lung cancer metastasis SRC PTEN PXN PMC9337267__F1 Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma KEAP1 FH EGFR ASL GLS PMC4380746__F1 Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention HEL-S-62p C5AR1 CD59 C4B_2 BCR LPO CR2 CR1 CP PMC6500672__F5 Putative suppressive pathway of Pj-ME in displaying its anti-inflammatory response TLR4 SRC SYK MYD88 STAT3 PMC6471124__F1 The MEK5–extracellular signal-regulated kinase 5 (ERK5) pathway with activators and downstream effectors PML FOXO3A FGF2 GSK3B CDC2 HIF1A IL1B STAT3 PMC6882186__F10 Proposed pathways for polysaccharide biosynthesis in Dendrobium moniliforme GMDS PMC2737000__F6 Androgen receptor pathway PLAGL1 HSD11B1 PTGS1 SVIL BAG1 PMC4320664__F3 Drug targets downstream of receptor tyrosine kinases involved in synovial sarcoma (RTK) SS18 EGR1 BAD IGF1R FOXO3A ATF2 GSK3B PTEN MTOR IRS1 FBXW8 TSC2 RICTOR TSC1 DUSP10 BCL2 MCL1 GRB10 BAX PMC2737000__F5 Arachidonic acid metabolism pathway CEBPD PLA2G12A PTGS2 GSK3B CCNB1 ALOX5 PLA2G5 NR1C2 CROT PTGS1 DVL1 PMC5123387__F24 (Abstract P2) TEF RHO TGFA PMC3367986__F2 Comparative Genomic Analysis of Soybean Flowering Genes PRR9 CRY1 MSI1 CRY2 RFWD2 EFS ELF3 MAF1 ELF4 PRR7 AGL PAF1 PRR3 PMC7865241__F7 Mechanistic scheme summarizing the anti-inflammatory effect of KMU-1170 NLRP3 TLR4 MYD88 IL1B PMC3104484__F5 Interplay between Wnt, Nurr1 and En1 signaling in vitro and in vivo EN1 PMC9666723__F8 Digital gene expression profiling of the transcriptional response to Sclerotinia sclerotiorum and its antagonistic bacterium Bacillus amyloliquefaciens in soybean UTP6 UTP4 POLL IMP3 NMD3 IMP4 PWP2 UTP18 LSG1 EMG1 NHP2L1 TCOF1 DRG1 NOP56 DKC1 NHP2 RAN NOP58 BMS1 NOP10 NOB1 POLI PMC8946083__F7 In Silico Analysis of Ion Channels and Their Correlation with Epithelial to Mesenchymal Transition in Breast Cancer CACNA1B EGFR MYC KCNN1 PTEN KCNT1 GJA3 CACNA1C GRIN1 SRC MAPK1 GJB2 JUN CLCN6 FGF2 ARHA ITGB1 GLRB HTR3C HEL-S-162eP GRK4 TRPC1 CDKN1A GJA1 KCNJ10 TRPC6 CDC42 PMC7177247__F8 CBD blocks the IL-1B/IL-1RI/Beta-catenin pathway and induces an epithelial phenotype BIRC3 RAC1 ID1 PMC7260729__F8 RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis AOC2 PMC6116402__F2 Highly connected networks built using reperfusion-upregulated mRNAs coding for proteins known to interact with human proteins ITGB3 PLAUR SOCS3 FOS ATF3 DDIT3 PPP1R15A GATA2 FLT1 ZFP36 JUNB JUN KLF6 PMC6365711__F10 miRNA-223 may be an anticancer gene in NSCLC through the PI3K/AKT pathway by targeting EGFR EGFR CCND1 BAX PMC7764608__F5 NF-ĸB signaling pathway IRAK1 PIM2 MYC CD44 TRAF6 IRAK4 MYD88 RGS13 CD79B CD79A PIM1 CARD11 BCR BCL2 SYK JAK1 STAT3 PMC4288116__F4 Schematic illustrating the effect of p53 alteration on apoptotic pathway in basal-like breast cancer cells NFKBIA TRADD IRAK1 TNF FADD PMC4948960__F6 Pathway analysis of network signaling of some of the identified proteins as represented in the ingenuity pathway analysis database MXD4 SCARB1 CLIP2 MNT ZFP36 RUNX1 NFIB MAPK14 CEBPA DUSP2 MXD3 MEOX1 PMC5959262__F8 The protective mechanism of curcumin by the UPR-Nrf2 pathway after DAI ELF2 KEAP1 ATF4 GSK3B BAX PMC8461142__F1 Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation NAMPT SIRT1 NRK SIRT3 PMC8218021__F3 Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson’s Disease ATG16L1 ATG12 ATG3 ATF4 BCL2 ATG10 TRAF2 DKFZp686F0183 FOXO1 NBR1 GABARAP PMC3080858__F6 PDP-1 Links the TGFB and IIS Pathways to Regulate Longevity, Development, and Metabolism IGF1 PPM2C SKI PMC9189345__F2 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease GC SHH SMO PMC8430824__F1 Ferroptosis and Synthetic Lethality Strategies GPX4 CDKN1A SLC7A11 DPP4 GLS2 SLC3A2 VDAC3 PMC9189345__F1 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease SMAD2 APC SMAD4 PMC9404924__F2 Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis MFN1 PINK1 DRP2 PMC9564314__F7 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia MUC1 SRM JAK1 STAT3 PMC6249032__F2 Overview of Cdc5 functions in key cell cycle pathways CIB2 NET1 CDC2 CDC42 PMC9564314__F5 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia MUC1 EGFR SRM MYC CCND1 SRC TCF4 PMC2652867__F1 PML regulon model is used to explain the effects of the PML protein and PML nuclear bodies on survival signaling as described in the text PML GSK3B MDM2 CCND1 EIF4E MTOR SKP2 CCNE1 PMC4249369__F1 Pantothenate and coenzyme A biosynthetic pathway PANK4 PANK3 COASY PANK1 PMC2857326__F7 TGFB induces apoptosis in human B cells via transcriptional regulation of BIK and BCL-XL BCR BIK TGFBR3 FADD BAX PMC6662984__F1 A2-3-sialyllactose showing PDB numbering C6 C4A PMC5825082__F7 Dysregulation of the IFN-Gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia STAT1 JAK1 IRF-1 SOCS1 STAT3 PMC9564314__F9 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia EGFR GRB2 SRC PMC3973133__F6 Schematic showing actin cytoskeleton signaling pathways in adult hippocampal spines (see ) and the proposed mechanisms by which the glucocorticoid receptor (GR) affects actin assembly and stabilization ARHA RHO CDC42 PMC2128044__F12 Hierarchical representation of the JAK-STAT pathway with SOCS1 subsystem as a coordinator STAT1 SOCS1 IFNG PMC2276871__F1 Steroid receptor expression in postnatal day 5–10 developing prostates from oil-treated control rats (A) and neonatally estrogenized rats (B) RXRB RARA RXRA PMC3420817__F6 12-LIPOXYGENASE AND THE REGULATION OF HYPOXIA-INDUCIBLE FACTOR IN PROSTATE CANCER CELLS PTEN HIF1A MTOR PMC3509372__F1 Treg regulatory pathways CD80 CTLA4 ICOS FOXP3 PMC9110515__F1 White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure TLR4 CCL2 IRS1 PMC7565148__F7 Summary of WARS1 signaling pathway in macrophages TLR4 SYK CXCL2 MYD88 PMC6852217__F1 Genes encoding the enzymes involved in Vitamin D action and metabolic pathway CYP27A1 NR1i1 CYP2R1 CYP24A1 CYP27B1 PMC2722023__F4 Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program ENPP1 IKBKE RBP1 IKBKG AP2A2 BAG4 RALA SLC7A7 CRAT IRAK4 MYD88 SNAP29 TMED3 RASA3 ORM1 ACOX1 CLINT1 G0S2 GGA2 CIDEC SREBF2 MASP2 LPXN VNN1 RDH11 RSAD2 AACS TNFRSF19 FKBP5 RGS2 CHAC1 STAP2 HYOU1 EXOC5 HMGCR ASAH2 RET TMEM97 PMVK PDGFC MLXIPL PRODH KHK ACLY ARF6 PPARG KIFC3 RGL2 PMC7801281__F3 ROS production mediated by diverse signaling pathways GPX4 CS LPCAT3 FACL4 ACSF2 GLUD1 PMC5729474__F4 The highlighted metabolic alterations in leiomyomas of the FH and MED12 subtypes MED12 ADSL FH HMOX1 PMC10474176__F6 NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway PDC UBA3 CCL2 CSF2 IL1B PMC2643067__F1 De novo purine biosynthesis pathway ADSL PMC5694536__F7 Schematic diagram depicting the role of Hoxa2 in proliferation and osteogenic differentiation of the palatal mesenchyme AIP RUNX2 HOXA2 SP7 PMC3082324__F7 Serpinin formation, its signaling pathway, and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells CGA SP1 PMC5364965__F2 Notch gene signaling pathway interactions NOTCH2 NOTCH4 NUMB JAG2 LFNG NOTCH1 DVL2 HES7 HES1 PMC8689194__F3 Endotoxin causes inflammation and leaky gut through activation of NFKB pathways CD14 LBP TRAF6 MYD88 PMC6620596__F2 STAT3 signaling pathway and inhibition approaches EGF EGFR SRC IL6 IL6R CPA1 STAT3 PMC7796296__F9 Involvement of the ERK/HIF-1A/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells XCR1 XCL1 CDH2 PMC4195781__F1 Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia KIF7 SUFU EVC PMC3652284__F1 Regulation of Wnt/Beta-catenin Signaling within and from Osteocytes APC SOST LRP5 LRP6 SFRP1 PMC3252978__F7 Summary of the results presented in this study ARHA RAC1 RAMP2 PMC3314865__F3 Targeting Mutant BRAF in Melanoma: Current Status and Future Development of Combination Therapy Strategies BRAF NRAS PRKD3 PTEN RB1 MTOR ARAF PMC3024228__F1 General pathway for phosphatidylinositide (PI) synthesis PI3 PIKFYVE PTEN PMC7017348__F5 Multi-component feedback loops and multi-component signaling networks involving SNAIL and non-coding RNAs NUMB IGF1R TCF4 ZNF652 PMC4461463__F1 Scheme for arginase catabolism of L-arginine to L-ornithine/urea or L-citrulline/NO, production of polyamines and anabolism and catabolism of proline OTC ASL PMC6232116__F2 Communality network analysis for k-clique 9 EGF RPA3 MAPK8 BLM ATF2 EGFR INS NBN RBBP8 CITED2 MMP2 ATM SRC CDK4 CDH2 KAT2B FOS FGF2 ERBB3 MMP9 NCOA6 TOP3A NR1C1 LEP RAC3 CREBBP EP300 CDK2 RELA LCK GRB2 BCL2 ATR TGFBI CDC42 PMC6232116__F4 Significant correlation of degree centrality between the OncoPPi BC network and our BC integrated network (p < 0.05), (r2 = 0.23688) FGF4 CHUK HGF MAPK8 EGFR GSK3B INS MYC MAPK14 SMAD4 MTOR CDK6 FYN SRC CCND1 IL2 CDK4 JUN FOS ERBB3 RAC1 IRS1 FOXO1 CBL MLST8 IKBKB RPS6KB1 ITGB4 NFKB1 ITGA6 IL2RG RELA STK11 PIK3CA ITGAV JAK1 RAF1 SOS1 SHC1 CDC42 STAT3 PMC7582904__F2 Mechanisms for restoring HLA class I expression STAT1 EGF BRAF EGFR PMC5642705__F5 Macrophage response to cpsA deletion ME1 CXCL1 IL1A TRADD CXCL3 CXCL2 CCL7 CCL4 IFNB1 CCL2 MX2 MX1 IFI44 CD1E CCL22 IFIH1 DNA2 FADD IFIT1 PMC7490531__F7 Illustration of the IRE1-RIDD-miRNA Pathway in Luminal Breast Cancer Malignancy RET RAB3B XBP1 PMC3180262__F8 Hypothetical molecular signaling pathways of the expression of p27 by which moderate increase in the concentration of D-(+)-glucose down-regulates and deficiency of D-(+)-glucose or L-leucine up-regulates the expression of p27 TSC2 EEF2K TSC1 SIRT3 PMC4020998__F1 Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer SHE IRS1 RXRA PMC6082930__F3 Smurf2 as an oncogene SMURF2 EGFR GSK3B PMC9348941__SF2 Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 KEAP1 LPO TNF PMC4748851__F2 Neurofibromatosis type 2 EGFR CD44 RHO EIF3C CDC42 PMC8005619__F2 DNA Sensing pathways by herpesvirus CGAS IL18 IL16 IRF3 AIM2 PMC8005619__F1 Intracellular sensing of herpesvirus DNA by DNA sensors and activation of signaling pathway CGAS IL18 TLR9 IRF7 IRF3 MYD88 AIM2 IL1B IFI16 PMC9393484__F1 Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling PDE10A ADCY5 GNAO1 GNAL DRD1 DRD2 HPCA PMC6754303__F2 Pathogenesis and Clinical Features of the Acute Hepatic Porphyrias (AHPs) ALAS1 FECH HMBS HMOX1 PMC4176998__F9 Schematic diagram demonstrating speculated roles of ER stress signaling pathways in diabetic cardiomyopathy. Firstly, under pathological condition of hyperglycemia in myocytes, ROS is generated by glucose oxidation in mitochondria ATF4 EIF2A TRAF2 PMC5930467__F6 Verteporfin in bladder cancer cell ANKRD1 LATS1 LATS2 PMC3668775__F9 Proposed model for the attenuated response to type I IFNs in human pluripotent cells ISG15 STAT2 IRF9 TYK2 JAK1 PMC2943859__F5 Death receptor signaling and its interdigitation with the mitochondrial pathway of apoptosis FADD PMC9600385__F2 Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance MAPK6 MAPK3 CAND2 PMC6590351__F4 Potential therapeutic target proposed to block leukaemia properties induced by the presence of CBFA2T3‐GLIS2 CBFA2T3 AURKA PMC6977166__F2 Overview of the affected pathways in the THP-1 cells after treatment with the free MTX and MTX loaded NPs GGH FPGS PMC10770036__F0 Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer TBK1 CGAS CXCL10 IRF3 CCL5 B2M PMC9246955__F2 Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-Beta-catenin pathway BAD APP PMC9117704__F2 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms PTEN BNIP3 PCNA STAT3 BAX PMC8503266__F1 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects PAK1 CD44 CDC42 PMC4385926__F9 Simplified model depicting (a) Novel positive feedback loop between TGF-Beta-SMAD3 and KLF17 in cancer cells SPARC CADM1 SATB1 MTDH KLF17 PMC5278824__F1 Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives ABCB6 FECH UROD UROS CPOX PMC10955158__F5 FLRT3 and TGF‐B/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia NODAL ALK FLRT3 PMC9117704__F5 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms STAT3 PMC3159046__F6 Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood DAAM1 CREBBP BMPR2 NFATC4 CDH8 PCDH17 WNT7A TGFBR1 GSK3B TGFBR2 FZD7 PMC8040227__F2 Canonical and non-canonical activation of NLRP3 NLRP3 IL16 TRADD IRAK1 TRAF6 IRAK4 TRAF2 PMC2083698__F6 Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma CYLD NFKB1 TRAF3 LTB TRAF2 LTBR PMC10648520__F8 Brief Review of Bone Cell Function and Importance LRP5 LRP6 PMC6028652__F7 Model of MAPK signaling pathway in MAP3K1; MAP2K4 wild-type or mutant cells DUSP4 MAP3K1 MAP2K4 JUN PMC8603984__F6 cGAS/STING: novel perspectives of the classic pathway TBK1 PINK1 CGAS IRF3 MCU MTOR OPTN MLKL BAX PMC8503266__F3 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects EGF LTB RELB PMC8503266__F2 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects COX2 PTGS2 LATS1 PTEN MOB1A LATS2 PMC7980590__F6 Flow chart for the functions of miR-4429 and DLX1 in PCa cells IMPACT DLX1 PMC6258145__F6 Pictorial Abstract showing that the molecular or therapeutic inhibition of TRPM7 expression and/or activity attenuates the cancer stem cell-like and metastatic phenotypes of lung cancer cells through the modulation of the Hsp90A/uPA/MMP2 signaling SOX2 MMP2 KLF4 CDH2 TRPM7 PMC12056177__F10 Schematic description of kinase signaling pathways in Amyotrophic lateral sclerosis TBK1 ULK1 RIPK3 PTEN OPTN FUS VPS26B TTBK1 RIPK1 WDR41 HEL-S-44 C9orf72 MLKL NEK1 PMC3357548__F3 TWEAK signaling pathway: illustration of the TWEAK signaling pathway as visualized in NetSlim web page CHUK CAST RELA RELB TNFSF12 CCL2 TNF JUN FADD PMC3133775__F2 Second messengers and membrane trafficking direct and organize growth cone steering TRPC1 SEMA3A NGF TRPC6 TRPC3 DCC BDNF PMC8921770__F9 Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis CTSK NFATC1 MMP9 DCSTAMP ACP5 PMC8007973__F4 The Wnt pathway in normal tissue (A) and in our two pancreoblastoma cases (B) APC LRP5 LRP6 PMC8229878__F3 Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis IGF1 RUNX2 CYP11A1 IRS1 CCS PMC3539134__F2 Inhibition of insulin signaling pathway by SOCS1 and SOCS3 SOCS3 IRS1 SOCS1 PMC8087698__F1 Serine synthesis pathway (SSP) and downstream anabolic pathways PSAT1 PSPH PHGDH PMC7505148__F5 CORM-A1 on glycolysis and pentose phosphate pathway (PPP) metabolites in platelets F2 HEL-S-133P HEL-S-162eP PMC5143318__F7 In silico analysis of Noggin interactions with other proteins GDF6 NOG GDF5 BMP6 BMPR1A BMP2 NKX2-5 BMP5 BMP7 GATA4 BMP4 PMC8275408__F1 Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures HMGB1 MYD88 TNF PMC6591367__F7 Possible underlying mechanism of PAR4 signaling PTEN MTOR FOXO1 FOXP3 PMC7219893__F1 (Color online) A schematic overview of the indices of mindfulness and anxiety demonstrating their inverse relationship CRP LPP PMC9178270__F1 Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease TBK1 IRF3 MAVS PMC8947539__F1 Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions MICB MICA PRF1 ORAI1 PMC3763924__F1 Pathways of ICL repair REV1 FAN1 SLX4 FANCM PMC11048425__F5 Proposed metabolic routes associated with lipid and Beta-carotene biosynthetic pathways in ΔcarRP WJ11 in comparison with the WJ11 strain CIT GLA NDP PMC3805859__F1 Integration of microRNA and epigenetic regulation pathways AGO1 AGO2 EZH2 HDAC1 TARBP2 PMC8797156__F2 Research Progress on Leucine-Rich Alpha-2 Glycoprotein 1: A Review ALK SMAD2 ARHA PMC6156139__F2 Smad-dependent and Smad-independent pathways of TGFB signaling associated with EndMT SMAD2 SMURF2 GSK3B SMURF1 PMC5922974__F6 Genes directly effecting TAG biosynthesis in R HEL-S-49 PCK1 FBP1 MPC1 MPC2 ENO1 ACLY NDE1 HEL-S-68p PMC4806601__F1 Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis AGO1 AGO2 AGO4 PMC9633197__F7 Molecular Mechanism of Epimedium Extract against Ischemic Stroke Based on Network Pharmacology and Experimental Validation TH LIF PROC INS STAR PMC3583293__F7 Model depicting how Shh promotes CGNP proliferation through combined effects on Gli1/2 and the mTOR pathway components eIF4E and S6K SHH SMO EIF4E IRS1 PMC4434964__F9 Models of EGF network and CNP/NPR2 signaling in the regulation of LH-induced ovulation EGF NPR2 EGFR CNP NPPC PMC9687797__F3 Epigenetics in the Development and Progression of Multiple Myeloma ATF4 STAT3 PMC7141597__F1 Division of labor between type I and type III IFNs in antiviral response IFNK TYK2 IFNAR2 JAK1 IFNAR1 IRF-1 PMC3602699__F9 Summary of signaling pathway by which PP-fold peptides increase cell proliferation NPY PYY MTOR PMC4091682__F1 EGFR/PI3K Pathway TSC2 EGFR CCNB1 PTEN MTOR STAT3 PMC3399380__F2 IGF-IR signaling pathway GRB2 MTOR IRS1 PMC5401756__F5 Resistin signaling TLR4 SOCS3 MYD88 TIRAP PMC5401756__F4 Adiponectin signaling via AdipoR1 and AdipoR2 activation ADIPOR2 SOCS3 MTOR NR1C1 PMC12219892__F2 Scheme of the study design and workflow for transcriptomic and metabolomic analyses SET GEM INHBA PMC5401756__F6 Visfatin signaling IL16 SIRT6 SIRT1 STAT3 PMC2857646__F1 Schematic of the TGFB signaling pathway SMAD2 SMAD4 PMC4281710__F2 NOD2-interaction partners influence a wide range of NOD2 functions ATG16L1 NLRC4 SOCS3 NLRP1 NLRP12 DUOX2 AAMP CARD6 RAC1 NOD2 NLRP3 CARD9 OAS2 CARD8 ERBIN CAD TRIM27 SLC15A3 SSH1 MAVS TRAF4 PMC4281710__F1 The domain architecture of NOD1, NOD2 and RIP2 NOD1 CARD6 NOD2 PMC8959940__F1 Microglia Polarization: A Novel Target of Exosome for Stroke Treatment CH25H NFAT5 IRAK1 SMAD2 NOTCH1 PMC9255238__F1 An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer IGF1R HGF IGF1 SRC PTEN EZH2 MTOR CD36 PMC6191506__F4 Hemoglobin production and redox homeostasis in erythrocytes FECH UROD UROS CPOX ALAS2 HEL-S-44 PMC4216012__F1 Wnt/Beta-Catenin Signaling Modulates Human Airway Sensitization Induced by B2-Adrenoceptor Stimulation DAAM1 APC GSK3B LRP5 LRP6 RYK ROR2 RHO FRAT1 PMC2784766__F3 Complex role of the PLAU-PLAUR pathway in the airways IL1A PLAUR PLG EGFR TGFB1 SERPINE2 IL1B PMC4036353__F8 How TAZ/YAP direct TGFBeta-induced tumorigenic events NEGR1 SMAD2 SMAD4 PMC8470361__F1 Glycogen Synthase Kinase-3: A Focal Point for Advancing Pathogenic Inflammation in Depression TLR4 BDNF STAT3 PMC7976442__F5 Kyoto Encyclopedia of Genes and Genomes analysis of predicted pathways KDR SYK AVPR2 CA12 PMC4983259__F1 O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling OGA OGT PTEN ACLY MTOR HEL-S-133P HK2 FASN PMC5401756__F2 Leptin signal transduction SOCS3 STAT3 PMC3634068__F6 Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters ALAS1 CYP2B6 CYP2C9 CYP24A1 ACLY DDT ABCC2 CYP3A7 RXRA PMC5968197__F6 Dual-lock for G1-phase arrest in unfertilized mature starfish eggs MOS CDC2 CDC45 PMC4176051__F2 Pathway analysis MYOF E2F8 CREG1 NDRG2 SGCA SLC39A1 MYBPC3 CRB3 CALML4 COL9A1 GFPT1 PMC6506414__F14 N-Linked glycan (A) and the calnexin cycle (B) EDEM1 EDEM2 EDEM3 UGGT1 PMC5968197__F9 MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes WEE1 ENSA ARPP19 CDC2 MYT1 PMC6952935__F1 Schematic representation of the metastatic cascade CD248 VEGFA PMC5389954__F2 Synthetic diagram of opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in cancer GSK3B MYC HEL-S-133P PMC9657779__F10 Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation SPHK1 TRAF2 BAX PMC5389954__F1 Schema of interactions between the canonical WNT/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in cancer APC MYC LRP5 LRP6 HEL-S-133P PMC3076924__F2 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders CASP3 MTOR BDNF PMC3076924__F4 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders ATF4 EIF2A HEL-S-44 TRAF2 XBP1 PMC7353017__F1 EGFR (epidermal growth factor receptor) and VEGFR (vascular endothelial growth factor receptor) signalization pathways PIGF EGF BRAF TFG EGFR NRAS PTEN HRAS MTOR PMC3433406__F5 Large scale phosphoproteome analysis of LNCaP human prostate cancer cells MYH9 TLE3 NPM1 KTN1 MORC2 TP53BP1 NOLC1 BCLAF1 MAP4 KHSRP SF1 HDAC2 CSTF3 RBM17 THRAP3 YBX1 MYEF2 MDC1 XPC SSB HUWE1 MCM7 CTNNA1 DHX16 FXR2 SRSF9 KRI1 HEL-S-102 RFC1 CANX NUFIP2 SSR1 TPD52L2 ABCC1 CTNND1 FIP1L1 HNRNPH1 CLNS1A NUMA1 SMN1 NSUN2 IGF2R PMC6327716__F6 The ubiquitylation of glycoprotein (GP) VI signalling pathway BTK FYN LYN SRC SYK PLCG2 PMC2777484__F1 Folate-mediated 1-carbon metabolism SHMT1 DHFR TYMS PMC6095079__F3 Findings of network and pathway analysis TMOD1 FCGR1A GNLY ALAS2 BCL2L1 KIR2DL3 IFNG MYBL1 BCR PRF1 KIR2DL4 TGFBR3 KLRC2 KRT1 PMC8402498__F11 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions CASK CRB3 RHO PTEN HEL114 COMP RAB13 PMC8402498__F10 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions BAD MAST2 PTEN PMC7092476__F6 Signaling pathway enrichment analysis of core targets of TWH for CD TH TNF FADD PMC4550442__F3 Acetylation of IFNAR-ISGF3 pathway is required for the antiviral activity of IFNA STAT2 IRF9 IFNAR2 IFNAR1 PMC4085347__F4 A mechanism showing tyrosine kinase receptor induced regulation of Nrf2 nuclear–cytoplasmic shuttling under redox homeostasis conditions LYN GSK3B SRC PMC4085347__F3 Diagrammatic presentation of regulation of Keap1-Nrf2-ARE pathway MAF SI JUN KPNA6 PMC9271918__F2 Molecular Mechanisms of Plant Responses to Salt Stress SNRK BAK1 BIN2 PMC9271918__F1 Molecular Mechanisms of Plant Responses to Salt Stress SOS2 BIN2 SOS1 PMC8435612__F2 Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases FZD3 IL18 GSK3B APP IL6 PMC7054735__F1 Therapeutic approaches for osteogenesis imperfecta SOST MSC LRP5 PMC4464465__F4 Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury TRADD TNF TRAF2 FADD BAX PMC6298633__F13 Schematic illustrating the potential contributions of ADAM9 (a disintegrin and metalloproteinase domain-9) to various chronic obstructive pulmonary disease phenotypes ADAM9 EGFR CCL3 PMC11857241__F2 Our manuscript denotes the neuroprotective effects of many phytochemical classes, including those from flavonoids and alkaloids, against neurodegeneration NLRP3 SIRT1 SOCS1 PMC7904598__F2 Bi-directional EV-mediated communication between astrocytes and glioblastoma cells IL16 GFAP STAT3 PMC11857241__F1 During neurodegeneration, critical pro-inflammatory and oxidative molecular pathways are involved in the occurrence of neurodegenerative conditions VCAM1 TNF SIRT1 PMC4412741__F2 Effect of Antibodies on Endothelium RICTOR CD59 SRC RHO GAL MTOR PMC4412741__F1 Effect of Antibodies on Endothelium VWF SRC RHO PMC7785707__F7 Proposed molecular mechanisms NLRP3 BCL2 MAF1 GSDMD PMC4204167__F2 The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2)-antioxidant response elements (ARE) signaling pathway MAF KEAP1 PMC10707854__F3 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis APC GSK3B COL1A1 PMC7589024__F10 Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐KB and TNF‐A/TNFR1/NF‐KB pathways HMGB1 TLR4 MYD88 TNF TRAF2 IL1B PMC10707854__F2 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis SMAD2 SMAD4 PMC10242070__F5 Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages IL21R TLR5 RUNX3 TLR9 IRF7 CYP1B1 SPINT1 IRF3 IDO2 FCGRT CYP1A2 AHR STAT4 CD84 CYP1A1 IRF-1 STAT3 PMC4734677__F6 Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye VEGFC DLL4 NOTCH1 PMC5919962__F1 Platelet targeted therapeutics SAP18 COX1 PLG HEL-S-11 VTN LYN VWF SRC RHO OTP GP1BA TF PMC5192336__F2 MUC induces inflammasome activation NLRP3 IL16 TXNIP PMC7704135__F5 Neuroactive ligand-receptor interaction signaling pathway TH AFP APELA SCT PMCH DAP PTH CALCR LHB TACR2 GRN VIP PRL LEP GHRL NPY UTS2 GHR TACR3 NPFF GAL ATR PMC9515687__F3 Inflammasome NLPR3 in the Development and Therapy of Periodontitis NLRP3 BRCC3 IL1B GSDMD PMC5214768__F8 Interaction map representing CNV-altered genes enriched in GO classes and grouped on the basis of their main biological processes TH NAT8L FPRL2 TCF3 GRIP1 KCNJ12 PPP1R8 SLC5A7 DACH1 LHX1 PSMG1 KNS2 SNAP29 GRN TCF2 RTN4R SYT15 PCLO WNT3 NRXN1 BCL2 GNB1L PMC8761767__F1 Interleukin-33/ Suppression of Tumorigenicity 2 in Renal Fibrosis: Emerging Roles in Prognosis and Treatment ACTA2 SIGIRR ATF2 IL33 TRAF6 IRAK4 CCL2 MYD88 PMC8358430__F1 Inflammatory Cytokine Storms by Mesenchymal Stem Cells CASP3 MSC STAT3 PMC7495247__F1 A) Schematic showing how COVID-19 triggers hyper-activation of the immune-response, generating a cytokine storm COX2 COX1 LTB PMC7677509__F6 Cyclin G2 inhibiting the growth and metastasis of OSCC by binding to IGFBP3 and regulating the FAK-SRC-STAT signal pathway MMP9 SRC CCNG2 STAT3 PMC3896626__F2 Interaction among differentially modulated genes in the apoptosis biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments CASP6 BAD NGF TRADD ATM IL3 BCL2 TNF FADD BAX PMC3896626__F1 Interaction among differentially modulated genes in the cell cycle biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments E2F4 SMAD4 DBF4 ORC3 CDK7 CDC45 ORC2 CDC6 SMC3 CDK2 MDM2 ORC1L RAD21 PCNA SKP2 MYT1 PMC10951222__F5 Tumor evolutionary analysis and clinical vignettes for patients who derived clinical benefit from palbociclib, everolimus, and exemestane triplet therapy KMT2C NF1 ERBB2 PIK3CA PMC9351107__F3 Targeting KRAS mutant cancers: from druggable therapy to drug resistance SOS1 MTOR PMC4686785__F8 PPI human module ITPR2 PRKCE SEMA4C HOMER1 PLCG2 PTEN RHO SPAG1 MAGI3 CCL14 APBA1 APP ARFGEF2 TNP1 DLGAP2 PLCD3 NCALD AKAP12 ASIC3 WASF3 GLS2 PRKG1 NRGN RGS2 ERAS CRIPT TRPC7 TRPC1 PRKCB GRID2 TNP2 PFKFB2 GRIA4 TRPC6 DGKZ ITPKA AGAP2 PLCH2 PMC4012889__F1 Intricate network of TLR signaling and miRNAs DGCR8 TLR4 IRAK1 DROSHA TRAF6 IRAK4 MYD88 MAP3K7IP1 PMC8913022__F2 Statin Use in Patients With Chronic Liver Disease and Cirrhosis: Current Evidence and Future Directions KLF2 RAC1 CDC42 PMC11506310__F2 Non-canonical TRAIL signaling pathway RIPK1 ATF2 RIPK3 SRC RAC1 TRAF2 FADD MLKL STAT3 PMC8762167__F1 Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells BAD SOX2 DMBT1 HEL-S-44 NQO1 BAX PMC11506310__F1 TRAIL-induced pro-apoptotic signaling pathway APAF1 FADD BAX PMC6859927__F1 Representation of normal BRAF pathway BRAF POR PMC2878746__F1 Ret gene structure and signaling RET FRS2 SRC PSPN ARTN NRTN PMC2633625__F2 Toll-like receptors in skin TLR5 TLR7 TLR4 TLR9 TRAF6 IRF3 IRAK4 MYD88 TLR1 TLR3 TIRAP PMC6425986__F4 Proteomic Analysis of the Human Anterior Pituitary Gland SI OTOR PMC3913963__F5 Beta-adrenergic signaling modulates multiple cellular processes in tumor progression and metastasis BAD RAP1A MTOR STAT3 PMC2649725__F7 Model showing the activation of the JNK pathway upon challenge by UVB ROCK1 CAD H2AX PMC4530868__F4 MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction TNFSF6 MMP2 TRADD TRAF5 TIMP3 RELA VEGFA PTEN SP1 TRAF2 COL4A1 STAT3 PMC4594993__F6 General model for basigin promotes the membrane localization of CD98 and activation of B1-integrin HOOK1 RAB11A RAB22A ARF6 PMC7865797__F1 Carbon-source preferences and use in cancer metabolism PC SCD HEL-S-133P PHGDH PMC4167483__F2 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome EGF SUFU GSK3B LRP5 CCND1 LRP6 SMO TNF MTOR PMC4167483__F1 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome HHIP KIF7 SUFU EVC2 EVC CCND1 EFCAB7 SMO PMC10835878__F10 Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells MTOR TFAM HEL-S-133P HK2 PMC3915736__F2 Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy GIG8 CD27 APC KLF2 MTOR BCL6 PMC5342493__F5 Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma SMAD2 NRP1 TGFB1 PMC8396170__F2 RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions FER MMP12 SRC SCRIB PMC4326575__F1 Structure and signaling from the cilium and relationship with the autophagic pathway ULK1 PDGFRA SMO MTOR DKFZp686F0183 IFT20 PMC6534064__F1 Drugs targeting Wnt/beta-catenin signaling in Desmoid-Type Fibromatosis APC ADAM12 SOX11 LRP5 LRP6 PMC1569532__F1 Different types of regulatory T cells ITCH FOXP3 PMC6534064__F2 A schematic presentation of the Hedgehog signaling pathway and the drugs that interfere with this pathway in DTF HHIP DHH IHH SHH SMO SHB PMC8088752__F7 Integrated stress response-mediated activation of mammalian RNA-dependent mRNA amplification ELF2 DELE1 ATF4 OMA1 ATF5 PMC4559166__F1 Time-series transcriptome analysis for adaptive evolution of E RPIA CIT RPE SDHA PMC7663714__F2 Interplay between different proangiogenic factors and their corresponding modulatory microRNAs PIGF MMP7 MMP2 FRS2 FGF2 MMP9 VEGFA STAT3 PMC8962276__F1 Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro ALPL RUNX2 BMP2 ANKH PMC6959318__F7 Model illustrating possible functions of DGAT1 and DGAT2 in human skeletal muscle cells DGAT1 DGAT2 PMC7140640__F4 Molecular pathways of the unfolded protein response (UPR ATF4 EIF2A XBP1 PMC9438316__F1 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma CD63 ACLY HEL-S-162eP GLS PMC2674807__F2 Common polymorphisms in the genes associated with Alzheimer’s Disease (AD) CASP3 SNCA C9 A2M SORL1 GSK3B LPL APP NTS TNF MME APOE PMC6055827__F4 Lipopolysaccharide (LPS)‐ and serum amyloid A (SAA)‐mediated cellular production of inflammatory cytokines TBK1 TLR5 TLR4 IRAK1 IRAK2 TRAF3 TRAF6 IRF3 IRAK4 MYD88 TLR1 MAL PMC9438316__F2 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma NEK2 HEL-S-133P PHGDH STOML2 HEL-S-281 HEL-S-162eP PMC4783980__F2 Inhibition of Calcium-induced T Lymphocyte Apoptosis pathway PLCG1 CABIN1 MEF2D PMC2654747__F2 Summary of enzyme-catalyzed thyronamine deiodinase reactions DIO1 PMC9711860__F7 Illustration of how loss of cell–cell adhesion triggers cell migration TIAM1 SRC HEL113 RAC1 STAT3 PMC8694526__F2 Recent Advances in Osteoclast Biological Behavior TSC2 BTK TSC1 BASH GRB2 OSCAR TEC SYK RHEB PMC3946634__F1 Tumor suppressive signatures of miR-200 SOX2 MAML3 ZEB2 MAML2 CCND1 SUZ12 CDK6 GATA4 PMC9198352__F2 Strategies of LncRNA DLX6-AS1 on Study and Therapeutics DLX6 DLX5 MTOR FUS MAP4K1 PMC4220515__F1 Excess glucose and fatty-acid exposure linked to reduction of AMPK and consequent inflammation and fibrosis ADIPOR1 SMAD4 APPL1 PMC4590251__F1 PirB-mediated growth cone collapse and axon growth inhibition.A classical axon inhibition signaling pathway: Nogo on the oligodendrocyte surface binds to the NgR-LINGO1-P75 receptor complex on the neuronal membrane ARHA RHO LINGO1 PMC7564842__F1 Receptors and signaling pathways that activate the NFKB cascade TRAF6 IRAK4 MYD88 TRAF2 PMC5589138__F2 Normal and abnormal adrenal steroidogenesis in the zona fasciculata CYP17A1 CYP21A2 PMC3442804__F2 Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter EGF HRAS FADD PMC11989151__F9 Canonical MC1R signaling pathway SRC MC1R RXRA PMC4186703__F9 Non-Classical Renin-Angiotensin System and Renal Function ACE2 PMC8906937__F6 Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression EGF EGFR VEGFA MTOR PMC8195803__F3 Revisiting the role of mitochondria in spinal muscular atrophy MFN2 NCALD VPS13D PGAM5 PMC6323673__F7 Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line ZFP36 CARNS1 RBCK1 EDN2 PMC9405302__F5 Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants ME1 HEL-S-26 KEAP1 APC CTLA4 PMC2819585__F7 MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis PRC1 EZH2 PMC8280619__F1 Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury CXCL1 VWF CXCL2 PMC7791639__F7 Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFBR1/Smad2/3 pathway MMP3 ADAMTS5 COL3A1 SMAD2 MSC TGFBR1 SMAD4 CCND1 COL1A1 PMC7767860__F2 Canonical and non-canonical pathways of TGFB signaling SMAD2 SMAD6 SMAD4 SKI MTOR SMAD1 DKFZp781O1323 PMC3427792__F1 Akt isoforms and glucose homeostasis - the leptin connection TSC2 TSC1 IGF1 SESN3 EIF4E RHEB PMC4569842__F1 Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine ARG2 ACO2 CIT PMC11649616__F3 Cancer-associated fibroblasts crosstalk with extracellular matrix G3BP2 SMAD2 MYC SMAD4 LATS1 LATS2 PMC6770863__F1 TLR4–p38B MAPK–C/EBPB signaling pathway mediates the coordinate activation of UPP and ALP in cancer-induced muscle catabolism ULK1 TLR4 GABARAPL1 TRAF6 MYD88 TIRAP PMC8836041__F2 Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway TFEB GSK3B PMC5330258__F1 VD3 is metabolized to 25(OH)D3 and 1,25(OH)2D3 by the classical pathway or to 20S(OH)D3 and 20S,23(OH)2D3 by CYP11A1 CYP27A1 CYP2R1 CYP11A1 CYP27B1 PMC3954635__F4 Beta-catenin pathway PIGF PRKCE SMAD2 APC NMUR2 TACR1 ANXA6 LAMA3 FOXF1 PPP2R2B HINT1 SNCG PC DMBT1 BCL2 FANCA SMN1 ZC3H18 PMC9332053__F2 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data NLRP3 MOS BCR APC CD40 MTOR PMC9332053__F1 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data RICTOR TSC1 MTOR DEPTOR IL1B BPI SGK1 RHEB MLST8 PMC6143528__F8 Action of OR2AT4 activation by Sandalore® and (unknown) endogenous ligand(s) in human hair follicle epithelium OR2AT4 BAD c-fgr IGF1R IGF1 EGFR IGFBP4 MDM2 BCL2 HBEGF DIPLA1 BAX PMC3718392__F2 Targeting of PI3K/mTORC1 signaling in hamartoma syndromes TSC2 TSC1 CS PTEN RHEB PMC3718392__F1 mTORC1 signaling TSC2 TSC1 PTEN IRS1 RHEB PMC8899613__F8 Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach PLTP MOS LPL TRO APOD PMC11204099__F8 Chlorogenic acid and cinnamaldehyde synergism on Akt-mediated signaling pathway downstream target proteins MMP9 CDH2 PMC3844273__F6 Hypothetical estrogen signaling pathways in human cerebral vascular endothelial cells EGFR HBEGF TF PMC6771382__F2 Summary of HR processes and HR proteins reported for sumoylation and interacting with SUMO SLX4 SIX3 RAD52 RAD51 SIX1 RMI1 SIX2 SIX4 PMC6888459__F3 Intracellular trafficking of EAAT3 SORCS2 NUMB PMC6122073__F4 Single-strand break signaling ATM TOPBP1 ATRIP SSB ATR H2AX PCNA PMC3718996__F8 Graphs showing the different regulation of glioma cell signaling when cells were cultured on biomatrix, myelin and unmyelinated tissue (retina) ROCK2 LIMK2 LIMK1 ARHA PMC8342223__F3 Complex role of AIM2 in autoimmune diseases and cancers MFN2 IL22 MTOR AIM2 IL1B PMC7649293__F5 An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of Tooth Development to Control Amelogenesis FST MSX2 PMC5598536__F2 Canonical pathway illustrations of CBA classifier MAF GCLC FTL PMC4977872__F9 Hypothesis of “The regulation of H3K27me3 on S IL10 CXCL10 B2M IFNG PMC11641149__F1 Regulatory factors of mitochondrial dynamics, associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD) MFN1 PINK1 MFN2 MFF LRRK2 PMC5331536__F8 LSS improves cognitive function and prevents neuronal injury of AD rats via inhibiting the neuronal apoptosis signaling pathway BAD BAX PMC6916339__F2 SHIP2 regulates the insulin signalling pathway PI3 PTEN CD2AP PMC3262611__F1 Folic acid metabolism DHFR PMC3377643__F2 TGFB and Iron Differently Alter HBV Replication in Human Hepatocytes through TGFB/BMP Signaling and Cellular MicroRNA Expression RUNX3 NR1i1 TLX2 NODAL RUNX2 PITX2 SMAD2 HOXC8 GRB2 TRAF6 GSC SKI PMC8199207__F2 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers CGAS IRF3 PMC8199207__F1 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers IL10 CD80 PMC6550542__F2 Interplay between enteroviruses and the host autophagy pathway CALCOCO2 SNAP29 NBR1 PMC7299703__F8 Apoptotic signalling pathway BAD FAP APP CAD PMC7747089__F1 Induction of type I IFNs and ISGs by influenza virus STAT1 OASL CH25H STAT2 IRF7 IRF3 TYK2 MYD88 JAK1 IRF-1 NOD2 MAVS PMC6198670__F5 ARG1-arginine-immune suppression-fatigue pathway CD27 IL13 CCR7 IL4 ARG1 PMC10528430__F1 Microglial responses in Alzheimer’s Disease HEL-S-62p CD33 CX3CR1 HEL-S-30 TMEM119 TNF MTOR CD74 CR1 P2RY13 STAT1 CSF1R TLR4 HEL-S-2 IL33 LPL NDUFA9 SYK ITGAX APOE STAT3 HEL-S-281 CST7 PMC8107375__F5 Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells CXCL10 ACE2 TLR3 TMPRSS2 PMC3845396__F1 Regulation of AKT signalling activation BAD MDM2 CASP9 PTEN MTOR PMC6937972__F6 Strong association of calcium channel activity in NRXN1A+/− iPSC-derived neurons PROS1 APLN PPP2R2C TGFBR2 GRIN3B CACNA2D1 PMP22 CACNA1A CORO1A HRH1 GNG4 PDGFA CAV2 CHRM2 TGFBR3 F2RL2 PDGFRA ADCY1 CACNG3 PMCH RRAS FGF12 FGF17 CACNA1I NMU TNC ITGB4 CACNG2 SDC4 GJA1 RASGRF1 TRPC3 CXCL12 HCRTR2 CHRNB2 PMC7934421__F1 Molecular pathomechanism of CRP-mediated damage in ischemic or hypoxemic tissue HEL-S-62p PC C4B_2 FH CRP C4A PMC4863537__F1 Pharmacology and rationale for imatinib in the treatment of scleroderma SMAD2 SMAD4 SRC PMC4591505__F1 TCR-mediated integrin activation inside-out signaling PLCG1 LAT HEL-S-81p PMC9035407__F10 RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein FGF23 PTH SGK1 RGS14 NHERF1 PMC5879088__F1 Canonical leptin signaling in hypothalamic neurons POMC AgRP NOX4 STAT3 PMC3287363__F7 Working model of ID/anemia-suppressed hippocampal IGF signaling TSC2 IGF1R HIF1A MTOR IRS1 FOXO1 PMC4166762__F1 Glucagon-like peptide 2 receptor (Glp2r)-induced intracellular signaling in hypothalamic proopiomelanocortin (POMC) neurons POMC LEPR INSR PMC7797159__F6 Cis- and trans-networks of DEGs and DE-lncRNAs of muscle development-related GO terms and signaling pathways SHOX NLK WNT4 TAOK3 GRB2 SOS1 DUSP8 MEF2C TAOK1 CRKL RPS6KA6 PMC5791065__F1 Activation of the B cell receptor signaling canonical pathway in FCRx versus SIS: a schematic representation EGR1 BAD TCF3 CSK PTEN MTOR FOXO1 BCL6 BTK BASH PAX5 CD22 LYN GRB2 UNK SYK CDC42 APBB1IP CD19 PMC8456902__F2 Estrogens in polycystic liver disease: A target for future therapies? PGRMC2 EGFR SRC PGRMC1 GPER PMC8716792__F3 Ferroptosis Signaling and Regulators in Atherosclerosis SLC7A1 GLS2 NOX4 LATS1 LATS2 PMC8716792__F2 Ferroptosis Signaling and Regulators in Atherosclerosis MAF GPX4 TF PMC5669621__F1 Development of POMC neurons CNTF POMC SOX2 NKX2-1 NPY RAX SHH SIX3 BDNF STAT3 HES1 PMC9361782__F7 Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma DHRS9 RBP1 CRABP2 VEGFA HEL-S-53e RDH5 RBP7 RARA RARB CYP26B1 ALDH1A3 GJA1 CASP9 RBP4 RBP2 CCND1 DHRS4 FABP5 DHRS3 RDH10 BTG2 ALDH1A2 ALDH8A1 RDH11 PMC8002083__F8 Illustrated model for our proposed molecular mechanism of how moscatilin inhibits HCC cell metastasis through inhibiting uPA expression via down-regulating Akt/NFKB signaling pathway PLG HCCS PMC6274847__F2 Proline, ornithine, and arginine metabolism and transport in plants OTC PRODH2 CIT PMC6299256__F3 IL-27 induction by C STAT1 TLR7 STAT2 IFNAR2 MYD88 IFNAR1 NOD2 PMC6999710__F1 Mitophagy and Innate Immunity in Infection TBK1 PINK1 MFN2 FUNDC1 USP35 BNIP3 USP30 OPTN PHB2 NBR1 PMC3808116__F2 Schematic overview of multiple feedback loops in the PI3K pathway PTEN IRS1 PMC10526229__F1 Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies NOTCH2 NOTCH4 SI DLL4 FURIN DLL3 MTOR NOTCH3 PMC8589993__F5 Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer EGF NGF EGFR TRAF3 TRAF6 BCL2L1 MYD88 MMP3 IL18 TLR4 CSF2 JUN SELE CD14 FOS PTGS2 MMP9 HBEGF PARP1 RAC1 TNF TLR1 MAP3K7IP1 CNTF CASP3 IL15 NFKBIA PAK1 MMP14 VCAM1 RELA TRAF1 BCL2 CSF1 TRAF2 FADD TIRAP TAB3 PMC9019162__F3 Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence P1 MHC2TA CHUK PRM3 TRAF5 PRM2 TNP2 ERCC1 TNF SOCS1 CREB5 PMC11241191__F7 Schematic illustration of SRI regulating apoptosis in HCC SRI BCL2 STAT3 PMC6909887__F1 Mechanistic Target Of Rapamycin Complex 1 (mTORC1) signaling pathway with areas of potential pharmaceutical inhibition highlighted SLC38A9 CASTOR1 RHEB PMC2631022__F1 ECM-receptor interaction pathway enriched by human switch-like genes CD47 CD44 VWF CHAD CD36 PMC8120246__F6 Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage IKBKG FCGR1A CHUK PPP3CA MAPK8 TGFBR1 OSCAR CREB1 NCF4 PLCG2 IL1R1 CALCR FOSL2 IFNG STAT1 BTK CSF1R FYN BASH CYLD IL1A ITGB3 CTSK NFATC1 FOS IRF9 IFNB1 TNF MAP3K7IP1 IKBKB NFKBIA NFATC2 NFKB2 GAB2 FHL2 ACP5 SYK JAK1 CSF1 TRAF2 PPARG TGFB1 SIRPB1 SOCS1 AKT3 PMC6491894__F1 Deletion of both cytosolic superoxide dismutases impacts metabolite concentrations and enzyme abundance of TCA cycle (A), glycolysis (B), and pentose phosphate pathway (C) SDHC RPIA CIT RPE SDHD SDHA MAL SDHB PMC5869054__F5 ABeta-driven Wnt-PCP pathway activation DAAM1 EGR1 NAB2 KLF10 GSK3A LRP6 ARHA DKK1 PMC4752324__F8 Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension NOX4 PAH PCNA PMC12176845__F5 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) LIF STAT3 PMC12176845__F4 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) VEGFA PTEN MTOR PMC12176845__F3 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) SMAD2 LTBP2 SMAD4 TRAF6 PMC5300981__F3 TGFBeta-Smad signaling pathway in HSC SMAD2 TGFBR1 SMAD4 PMC11727080__F1 Fate of glucose and fatty acids in macrophages and HCC cells CS CIC HEL-75 CPT2 ACLY HK2 PMC11727080__F2 Crossroad in amino acid metabolism in macrophages and HCC cells SLC7A2 GC ORC1L ARG1 ORC2 ASL HK2 PMC3628764__F1 Alternate routes of endocytic traffic of activated tyrosine kinase coupled cell surface receptors and the role of Cbl-family protein dependent ubiquitination EGF EGFR CBL PMC9456329__F8 Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells MAF NLRP3 HMGB1 HEL-S-128m PMC4032345__F3 Comparative Proteomic Analyses Provide New Insights into Low Phosphorus Stress Responses in Maize Leaves GIP HEL-S-162eP PMC8998804__F1 Transcription Factors with Targeting Potential in Gliomas FOXM1 EGFR SMO POR TF STAT3 PMC7379485__F7 ALDHHIGH cells regulatory mechanisms in cervical cancer cells GSK3B LRP6 PMC11739089__F6 Research progress on the synthesis process, detection method, pharmacological effects and application of glycocholic acid LTA COX1 LTB PMC5848464__F1 Regulation of canonical and noncanonical pathways of NFKB activation by cylindromatosis (CYLD) CYLD RELA TRAF3 RELB CCND1 CD40 TRAF2 LTBR PMC3941170__F2 Cell cycle regulation by p16Ink4b/p14ARF MDM2 CDK4 CDK6 PMC11897346__F7 Graph model for the role of SR-A3 in protecting against MAFLD through the XIAP/PTEN/AKT axis PTEN MTOR PMC8843879__F3 Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential KLF6 PMC5641214__F2 Leptomeningeal disease: current diagnostic and therapeutic strategies GGH DHFR FPGS PNP PMC8997752__F5 Beyond PD-L1—Identification of Further Potential Therapeutic Targets in Oral Cancer CD80 PMC6424911__F4 Changes in transcripts related to phenylpropanoid metabolism in response to aphid feeding in susceptible plants PTS CAD PMC6186589__F1 Schema of sortilin regulating EGFR trafficking () RAB35 EGFR HEL-S-116 RHO MTOR ROR1 PMC6800172__F1 Chemical structures (Panel A) of decursin (D), decursinol angelate (DA) and decursinol (DOH), and likely metabolic pathway (Panel B) of D and DA based on rodent data and human studies in vitro and in vivo CES2 CYP2C19 CYP3A4 PMC9163565__F3 New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain CCR2 TLR4 IGF1 ASIC3 CX3CR1 TNF IL1B GDF3 PMC4487054__F1 Signaling of SGK3 and AKT TSC2 BAD CXCR4 PTEN SP1 FOXC2 ID1 FLII PMC5346358__F7 Mechanism of action of BNP inhibitory effect on LPS/ATP-induced IL-1B secretion in human THP-1 monocyte IL16 IL1B PMC8213587__F3 Rethinking the biology of metastatic melanoma: a holistic approach NF1 HEL-S-26 BRAF NRAS MYC PTEN HIF1A MTOR PMC7706714__F3 Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities MMP14 RUNX2 MMP9 CDH2 STAT3 PMC4150779__F7 Functional relevance of rapid transcriptional silencing in activated DCs NLRP3 CARD9 LTA COX1 BCL10 IRAK1 LTB TRAF6 SYK IRAK4 MYD88 PMC8698202__F2 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms RNASEL STAT1 STAT2 EIF2A TYK2 JAK1 PMC6530577__F3 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis ANGPTL3 CES1 ATF4 IRS1 PMC3082833__F1 During innate immune activation via LPS-LPB-TLR4, a number of factors of the coagulation pathway are activated, creating the cooperative immuno-coagulative response CD14 TLR4 APC RELB TRAF6 RHO MYD88 MAP3K7IP1 TF SKP2 TAB3 PMC8698202__F1 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms TBK1 IRF7 IRF3 MYD88 PMC6530577__F1 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis ATF4 EIF2A XBP1 PMC10137218__F4 WNK kinases regulate HCO3− versus Cl− secretion across human airway epithelia WNK1 OSR1 WNK2 ASL PMC6309157__F2 Molecular pathways that play central roles in mounting an immune response PMC5787570__F6 Inclusion membrane proteins and secreted effectors from C SNX5 SNX6 ARF1 PMC7231511__F1 MHC cross-dressing can promote interaction between helper or regulatory CD4+ T cells and effector T cells TH APC PMC10933445__F6 Model depicting the reciprocal interplay between miR-579-3p and MITF in BRAF-mutant melanoma cells through the modulation of MAPK signaling pathway ZFR BRAF PMC9290522__F3 Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19 STAT2 IRF7 TRAF3 TRAF6 IRF3 TYK2 IRAK4 MYD88 TNF MAVS PMC10452344__F1 Influence of microRNAs on the hippo signaling pathway in gliomas YAP1 NF2 LATS1 PMC11953571__F3 Exercise activates the EGFR/insulin signaling MAPK4 HEL-S-11 APP PMC8058408__F5 Pi3K-Akt and IL-17 signaling pathway (A) PI3K-Akt signaling pathway and (B) IL-17 signaling pathway, with key target genes in the yellow box BAD CHL1 BCR PTEN EIF4E GAL MTOR CDT1 HEL-S-69p PMC7825454__F7 Proposed signaling pathways regulated by HSV-2 infection and TRIM26 activation TBK1 IRF3 TRIM26 PMC8659385__F4 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses EGF EGFR MTOR PMC8659385__F1 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses BAD MAX PMC3775863__F3 MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention CTBP2 PPM1E RASD1 XPO6 CAP1 CREB1 CASP2 CDK6 CCND2 FNDC3A MTSS1 ANXA2 ZEB2 CCND1 PICALM ADIPOR2 YAP1 NCAM1 MAP3K12 EXOC5 BCL6 DKFZp761E1322 IGF1 TWF1 CCNG1 ADCY6 PIK3CA BCL2 ADPGK SOS1 LAMC1 BDNF CDK9 CLIC4 CP PMC7858612__F2 Ferroptosis: mechanisms and links with diseases LPCAT3 STEAP3 FACL4 ADA PMC7858612__F3 Ferroptosis: mechanisms and links with diseases GPX4 HEL-S-64p HEL-75 IPP HMGCR PMC4501067__F9 Biosynthesis pathway of neurotransmitters in insects TH ChAT DDC TRH ACHE AANAT HDC GLS PMC5173258__F1 Ivermectin induces cytostatic autophagy by blocking the PAK1-AKT axis in breast cancer cells PAK1 MTOR ATG14 PMC11383172__F2 IBT induced downstream upregulation of the TNFA pathway in human neutrophils CXCL1 SOCS3 TRADD CXCL5 TRAF3 CXCL3 CCL5 CCL2 NOD2 CSF2 IRF-1 CASP8 IL1B SELE PTGS2 LIF CXCL10 CXCL2 IL6 CASP10 MAP3K7IP1 CASP3 IL15 LTA TRAF1 CCL20 CSF1 TNFAIP3 TRAF2 FADD MLKL IL18R1 ITCH PMC4273126__F3 Molecular mechanisms of alcoholic fibrosis SP1 CYP2E1 PMC3775578__F1 Novel investigational drugs for basal cell carcinoma SUFU PTCH1 SMO PMC1594921__F6 Immunological regulatory IL-10 and MAP kinase pathways EPOR EREG MOS SOCS3 MAP2K4 FOS ATF2 PTGS2 MAPK14 TRAF6 PTEN RB1 RIPK2 CRK IL16 ADA CASP9 JUND MAPK1 ETS2 HEL-S-283 JUN SP3 PMC9148969__F8 Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response BAD ATG16L1 IGF1R TLR9 IGF1 EGFR BCL2 BAX PMC1594921__F5 Presymptomatic and symptomatic infections including the inflammatory cytokines TNFA, IFNG, and ILB CD14 CDA HIPK2 FTH1 IFITM2 CYBB TNF CD74 HPSE IFNG LCP2 IL18 TAP2 RELA REL ICOS PSME2 PMC8147802__F2 Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach IGF1 BAK1 IGF2 CXCR4 BCL2 BAX PMC8016624__F4 miRNAs involved in the autophagy pathways ELF2 ATG12 EIF2A MTOR MLST8 PMC7761462__F1 Angiogenesis-related functions of the Wnt/Beta-catenin signaling pathway in colorectal cancer (CRC) APC LRP5 HIF1A PMC5679442__F1 Stromal niche for epithelial stem cells: a template for regeneration and a brake on malignancy HGF IGF1 GHR SHH BMP7 BMP4 FGF7 PMC8016624__F1 MicroRNAs (miRs) that regulate the apoptotic signaling pathways APAF1 DIABLO FADD PMC3051378__F5 Resulting endoplasmic reticulum (ER) stress and unfolded protein response (UPR) gene network from a modelling approach using the set of differentially regulated genes common to all pancreatic cancer cell lines after nemorosone treatment HEL-S-89n EGR1 FOSL1 BAK1 CDKN1B BCL2L11 HMOX1 HEL-S-22 CASP3 GPX2 ASNS CCND1 CDK4 MCL1 BTG2 JUN PMC9271835__F1 Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection HMGB1 HEL-S-64p TRAF6 MYD88 PRX PMC4231685__F9 Metabolic and transcriptional profiles for components of the TCA cycle (A) and BCAA biosynthetic pathway (B) HEL-S-26 ACO2 HEL60 HEL-S-32 MDH2 PMC8354730__F2 Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders HEL-S-62p TLR4 CS GSK3B AQP4 TNF APOE PMC4127235__F2 Beta-Catenin is an antagonist of the NFKB pathway LRP5 LRP6 PMC11856472__F3 Crosstalk between Wnt, Notch, TGFB, BMP, and Hedgehog signaling pathways SMAD2 APC GSK3B MYC SMAD4 ARHA RAC1 HES1 PTCH1 SMO VANGL1 SMAD1 DKFZp781O1323 PRICKLE2 PMC10537413__F4 Unraveling MYC’s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance PLK1 MAX MYC USP28 USP36 MTOR CDK9 CDK7 BRD4 PMC11707140__F5 Dysregulated expression of genes associated with neurovascular coupling TRPV4 PLD2 PTGS2 KCNJ2 ARHA PTGS1 PMC4127235__F1 Wnt/Beta-catenin pathway APC LRP5 LRP6 PMC2778230__F3 Apoptotic signaling in aging muscles GIG8 TRADD APAF1 FADD BAX PMC7564842__F2 Signaling crosstalk between the KRAS and NFKB pathways TBK1 IRAK4 RALB MYD88 IL1B PMC5679229__F3 Nitric oxide - the forgotten child of tumor metabolism HEL-S-30 FASN GLS PMC11117676__F2 The nuclear signaling pathway of RIP-mediated EpCAM BACE1 LEF1 EPCAM FHL2 PMC8213731__F8 Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model DDR1 SMAD2 SMAD4 DDR2 PMC9403516__F8 Astragaloside IV promotes pharmacological effect of Descurainia sophia seeds on isoproterenol-induced cardiomyopathy in rats by synergistically modulating the myosin motor NPPA TPM1 HEL-S-273 PMC9685729__F2 Noonan syndrome: improving recognition and diagnosis RIT1 NF1 GRB2 PTPN11 SPRED1 SHOC2 CBL PMC9935929__F5 Signaling pathways in rheumatoid arthritis: implications for targeted therapy BTK ATF2 GSK3B SYK RAC1 HIF1A MTOR NAV2 PMC5454641__F1 mTOR Signaling Pathway TSC2 TSC1 RHEB PMC5347766__F9 PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway RPL11 ATM MDM2 RPE PMC4859092__F1 Workflow of the PSF-SOM method as applied to lung diseases HP UNK PMC7974515__F7 Graphic summary of this study TGFBR1 TGFB1 PMC4859092__F8 Community detection in the lung disease graph HP PMC2773833__F3 Drivers of senescence and therapeutic opportunities in WS and HGPs ATM ATR TF BAX PMC4602270__F6 Label-free Quantitative Analysis of Changes in Broiler Liver Proteins under Heat Stress using SWATH-MS Technology POSTN CNP PLCG2 HSD17B7 CYBB HEL117 HEL-S-61p FBLN5 HEL-S-125m CTSG HPGD SPINK5 AHSG GFER SLC16A2 ABCA1 PMC6527386__F1 Molecular factors involved in cell migration SUN1 RAC1 CDC42 PMC7597513__F2 This is a simplified version of the canonical nuclear factor kappa B cell (NFKB) pathway that is negatively regulated by A20 binding inhibitor of NFKB (ABIN1) function IRAK1 TRAF6 IRAK4 MYD88 PMC3743959__F1 Toll-Like Receptor (TLR)-Associated Sequence Variants and Prostate Cancer Risk among Men of African Descent CASP3 CD14 BTK NFKB1 IRAK2 TRAF6 IRAK4 LPA MYD88 TNF IRAK3 TIRAP PMC4596921__F1 mtROS in bacterially triggered immune responses STAT1 TRAF6 HEL-S-44 ECSIT PGAM5 TNF MLKL PMC6013556__F1 Pathway activation after damage-associated molecular patterns (DAMPs) stimulation CD14 HMGB1 TLR4 IRAK1 IRAK4 MYD88 PMC3914352__F10 Flow diagram representing the molecular interactions in the Toll-like receptor signaling pathway (from KEGG database) TLR8 CD14 PDC TLR7 TLR9 TRAF6 RAC1 MYD88 TLR3 TIRAP PMC4115628__F2 Sphingolipid metabolism CS PC DES SMS PMC12210125__F3 Tumor cell-macrophage interactions reprogram M2 TAM polarization YTHDF2 CCR5 CXCR1 TDG ALK LIF ETV4 CXCL8 CCL5 CCL2 HIF1A RNASE1 COX2 IGF2BP3 MISP SYK STAT3 PMC4424324__F7 Integrin-mediated signaling pathway that regulates actin polymerization, actin cytoskeleton remodeling, and microcluster formation HEL-S-28 CDC42 PMC12210125__F2 Signaling pathways for the polarization of TAMs towards the M1 phenotype YTHDF2 BATF2 DLL4 SYK IRF4 IFI16 PMC5133779__F4 Differentially expressed proteins involved in HIF-1 signal pathway ENO3 EPO VHL TFRC IL6 HEL-S-87p HMOX1 HEL-S-68p HEL-S-26 TLR4 FH PCK2 HEL-S-133P TF PMC8616465__F1 Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas AHR SSB RAD52 RAD51 PMC7427779__F8 Schematic summary of this study ELF1 RAC1 PMC6121518__F1 Crosstalk between Hh signaling and autophagy based on current evidence DHH IHH GLI3 EIF2A GSK3B ALOX15 SHH ALOX5 SMO BNIP3 MTOR VMP1 PMC11901361__F2 Proposed FRAlpha-mediated endocytosis and signaling pathways in cells STAT3 PMC6563035__F1 PD-L1 reverse signaling in tumor cells and macrophages CD80 IFNG PMC10357943__F3 Shining a light on the dark proteome: Non‐canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology CIP2A EGFR USP28 SRC SMIM30 FBXW7 AKT3 STAT3 PMC10757071__F5 Significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease TNFRSF1B TLR4 EZH2 TGFB1 HEL-S-133P PMC2586335__F1 Ras signalling pathways BAD CCND1 JUN PMC12052831__F1 FAS mediates apoptosis, inflammation, and treatment of pathogen infection FADD BAX PMC4708176__F2 ERK and non-ERK mediated non-genomic AR signaling SHBG SRC RAF1 MTOR FOXO1 TF PMC7794986__F2 Molecular basis of chemoresistance in GBM E2F7 SP1 PMC11333789__F6 Effect of rotenone on regulating the Nrf2 signaling pathway and induction of Parkinson’s disease was proposed FES BDNF PMC12052831__F2 FAS mediates apoptosis, inflammation, and treatment of pathogen infection NOX3 EGF RIPK1 SRC MAP3K7IP1 FADD STAT3 TAB3 PMC11044150__F10 Modulating the MAPK signaling pathway of LQZ against AD EGF MAX GRB2 TRAF6 MYD88 TNF MAP3K7IP1 PMC7956987__F1 IL-18 signaling pathway TRAF6 MYD88 IL18BP PMC11972507__F6 ceRNA Network of m6A-modified circRNAs in OSA-induced Cardiac Injury BACE1 CARM1 HACD2 HECTD4 SUSD6 SENP2 PLD4 FBXO27 BICDL1 TMED4 SLC35E1 KLC2 CDPF1 COPS7A GGCT ERMAP HHIPL2 ARHGEF7 FOSL1 VIPR2 PAQR4 DECR1 VAMP1 ST6GALNAC6 DOLPP1 ARFGAP2 CLIP2 RFX2 HEL-S-1a FADD PMC10869798__F2 Microglial activation and neurodegeneration SYK TNF IL1B PMC7784643__F1 Canonical and non-canonical signaling pathways of AhR AHR SRC PMC3632094__F8 The process of LC3-associated phagocytosis (LAP) RIPK3 DKFZp686F0183 PMC4468438__F1 Major pathways for the metabolism of IFO CYP2B6 CYP2C9 CYP2C19 CYP3A4 PMC9317256__F1 Biosynthesis of Non-Endogenous Apocarotenoids in Transgenic Nicotiana glauca HEL-S-62p PMC8834185__F2 Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma PAK1 PMC9022980__F1 TNF-induced necroptosis occurs when upstream pro-survival and pro-apoptotic pathways are inhibited RIPK1 TRADD RIPK3 TNF TRAF2 FADD PMC3637854__F2 Overview of UPR signaling ATF4 EIF2A XBP1 PMC2582196__F2 Classic renin-angiotensin-aldosterone system (RAAS) pathway and angiotensin II (Ang II)/insulin signaling in the vascular smooth muscle cell IGF1 IRS1 PMC4651655__F1 Mevalonate pathway, NHRs and immunity SQLE LBR PGR EBP DHCR24 MVK HMGCS1 HMGCR PMVK NR1i1 ACAT1 MVD DHCR7 FDPS FDFT1 RORA PMC3665263__F2 Innate immune system in pneumococcal meningitis infection NLRP3 TLR4 TLR9 TRAF6 IRAK4 MYD88 AIM2 PMC2702319__F4 Distributions of the orthologous gene groups containing duplicate genes that arose through 3R-WGD (shown as gray boxes) in the network diagrams CS CLYBL CAMK4 FH DLD OGDH ACLY PMC6158718__F1 PI3K/AKT pathway TSC2 BAD TSC1 MYC MDM2 PTEN IRS1 RHEB PMC7052015__F1 Detailed illustration of the experiment MAF KEAP1 PMC6158718__F2 PI3K/AKT pathway in muscle tissue when normal state and insulin resistance EEF2K EIF4E TG EIF4B PMC7843693__F4 Therapeutic potential of mesenchymal stem cells in treating both types of diabetes mellitus and associated diseases MSC TNF IRS1 PMC5660598__F4 Dexamethasone (Dex) and monphosphoryl lipid A (MPLA) treatment leads to changes in the expression of genes involved in biological processes associated with immune response regulation C1QTNF1 FCGR2A CXCL5 TNFRSF6B ATP1B1 ALOX15 MYC CCL5 MRC1 ISG15 ALOX15B FCER1A MT2A IL7R THBS1 ETS2 CD14 FPR1 AIF1 S100A9 PLTP HEL-S-171mP ISG20 S100A8 CCL18 NCF1 GPR183 CD24 PMC11214942__F5 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions PIEZO1 SRC ARHA RAC1 CRK PMC11214942__F4 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions BAD BAX PMC10970410__F12 LncRNAs potentially involved in the immaturity-stemness regulation processes in the human keratinocyte lineage BAMBI SMAD6 KLF4 GDNF REL WNT5B BDNF FGF7 PMC10971967__F6 Proteomics analysis of gastrocnemius and soleus muscle in the ET group SIRT2 CASQ1 TUBB EHD2 PDK2 NDUFAB1 ENG PCCA LAMA4 COL1A1 PCCB MDH2 HEL-S-68p TUBB4B PDHA1 NDUFB10 APIP MAPK1 DLAT HK2 COL4A2 MUSTN1 PMC6406375__F1 Major calcium channels, pumps, exchangers and sensors in mammalian cells HEL-S-11 MCU CAD ORAI1 STIM1 PMC7459397__F1 FGF18‐induced ER‐phagy in chondrocytes TFEB FGFR3 FGFR4 FGF18 IRS1 PMC4344885__F6 Endocardial Fibroelastosis is Caused by Aberrant Endothelial to Mesenchymal Transition EGF SMAD2 BMP7 SMAD1 DKFZp781O1323 PMC3426835__F5 Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis CDK5 APP APOE PMC6160488__F4 Crosstalk between the interferon signaling pathway and PD-L1 signalosome STAT2 IFNAR1 STAT1 TTI1 CASP3 NF1 ATM PDS5B CASP9 VAC14 JAK1 ATR STAT3 PMC10838202__F5 mRNA-seq results of KEGG pathway enrichment analysis and western blot results NGF MAFK APP DES TNF TIRAP PMC3961774__F5 Role of Heme Oxygenase-1 in Postnatal Differentiation of Stem Cells: A Possible Cross-Talk with MicroRNAs RUNX2 BMP2 NFATC1 ATF4 MSC SOX9 PMC3179275__F4A Integrative computational biology for cancer research MAX JUN CRKL PMC6197618__F6 RHBDF1-facilitated membrane trafficking of pro-TGFA via CCV pathway EGFR AP1B1 TGFA RHBDF1 ADAM17 PMC5341867__F2 TP53 mutation hits energy metabolism and increases glycolysis in breast cancer ENO3 FBP2 G6PC2 FBP1 GLS2 ENO1 G6PC1 PFKL PFKM HEL-S-68p HEL-S-162eP HEL-S-278 G6PC3 ENO2 RPIA HEL107 PFKP HEL-S-20 PMC8176240__F6 Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression BAD POLK BRCA2 CASP9 SMAD4 RAD51 STAT3 BAX PMC4128997__F3 PPAR signaling pathway UBC PLTP UCP1 HEL-S-28 PMC4128997__F2 Antigen processing and presentation pathway CANX MHC2TA HEL-S-99n B2M IFNG TAPBP PMC3256879__F8 A hypothetical diagram of the involvement of ATF6 in BMP2-induced osteoblast differentiation RUNX2 BMP2 PMC5650102__F2 T Cell Signaling and Gene Regulation Defects in Systemic Lupus Erythematosus (SLE) CD44 MTOR IRF4 ICOS BCL6 STAT3 PMC2846061__F3 Ovary: basic biology and clinical implications EREG CTSL SFRP4 EGR1 RUNX1 RUNX2 NR3A2 PGR TNFAIP6 AREG PTGS2 EGFR BMP15 SNAP25 HAS2 PTX3 CCND2 BTC INHA EDN2 SRC FSHR SMAD1 PMC9409119__F2 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint RGS8 STK17B INPP5A PMC11284857__F3 Disturbance of DFC signaling pathways results in disorders of osteoclast differentiation TGFBR2 MSX2 TLL1 PMC9409119__F1 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint RGS8 STK17B TBP TRPC3 INPP5A PMC10982379__F2 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer BCL2 PTEN MTOR BAX PMC10982379__F1 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer GPX4 LPCAT3 STEAP3 FACL4 HEL-S-64p ALOX15 TF GLS PMC10982379__F4 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer GPX4 MGST1 TIMP1 SLC7A11 ARG2 ABCC5 HEL-S-29 STAT3 PMC10982379__F3 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer GPX4 SLC7A11 PTEN PMC8298031__F2 In vitro Assays and Imaging Methods for Drug Discovery for Cardiac Fibrosis ARHA TGFB1 CTGF PMC10982379__F6 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer GPX4 FTH1 SLC7A11 LCN2 ABCC5 CERK PGAM1 IFNG PMC3121540__F4 A gene network shows that mRNA levels of PDGFR and ECM-related genes are significantly correlated in human breast cancer SPARC DCN MMP2 FBN1 MFAP2 PMC10982379__F5 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer LPCAT3 STEAP3 FACL4 TF SIRT3 PMC9657596__F6 Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway HEL-S-30 CCND1 HEL-S-133P PMC10845554__F1 IL-17-producing Treg differentiation RORC CCR6 APC SMAD4 HEL-S-92n CTLA4 FOXP3 MAF TLR4 AHR IKZF4 CCR7 IL2 ITGAV DDX5 SKI IKZF2 ICOS STAT3 PMC8833974__F5 KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications GRB2 FOXP3 PMC4323371__F1 TERRA regulation of telomere length for the protection of chromosome ends involving TRF2 ATM CTCF PMC5316868__F2 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development PIK3CD PRKCZ PRKAR1A CA3 GPR108 EPHB3 AATK MAPK12 KDR GPR85 HEL-S-11 ROR2 AXL NTRK2 GPR37 SOS2 ADCY1 MAPK7 ERBB3 MAPK10 MAP3K7 GPR19 MAP2K5 HRAS RET PAK1 PRKCB GPR156 GRB2 MERTK GPR50 GPR183 GPR162 MAP9 PRKCE MAP2 GPR161 EGFR RYK GPR4 PTEN GPR155 EPHB4 ROR1 EPHB6 INSR EPHB1 GPR173 GPR27 GPR63 GPR153 GPR107 MAP6 ACKR5 KIT PDGFRA NTRK1 FGFR3 GPR137 NTRK3 MAP3K10 MAPK15 MAP2K1 MAPK6 MAPK4 GPR180 GPR135 ERBB2 GPR157 EPHB2 PIK3R2 PMC6139250__F1 NFKB signal transduction pathway CXCL1 IL1A MMP9 RELB MYC COX2 MMP2 BCR VCAM1 CDK2 TRAF1 RELA CCND1 CD40 TRAF2 PMC9928209__F2 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug HMGB1 CDK2 CDK4 MTOR CDK6 BAX PMC3970201__F2 Self-consumption: the interplay of autophagy and apoptosis ATG12 SRC MCL1 TNF PMC5316868__F3 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development DYNC1H1 PTCH2 WWC1 APC IFT172 DVL1 SUFU NF2 EVC2 PTCH1 DYNC2H1 EVC HBB SHH SMO PMC5837968__F6 Schematic illustration of SFKs mechanism of action in interferon regulatory factor 1 (IRF-1) K63-Ubiquitination TLR8 TLR7 TRAF6 IRF-1 PMC6943360__F1 An overview of MIF signaling pathways: MIFs interactions can contribute to the formation of cancer and neural development BAD CXCR4 CD44 IL8RB CD74 BAX PMC3673040__F1 Leptin is generated in adipose tissue and transported via the bloodstream to the hypothalamus POMC NPY AgRP MC4R PCSK1 BDNF PMC3763758__F1 HIV-related neuropathic pain pathway COX2 CXCR4 BDNF PMC8953969__GA STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) TBK1 CASP3 NLRP3 CGAS RIPK1 RIPK3 DDX41 IFNAR1 AIM2 ZBP1 MLKL GSDMD PMC7444278__F3 Major components of the vertebrate Hedgehog pathway are dynamically localized to the primary cilium in response to Hedgehog ligand KIF7 SUFU PTCH1 GPR161 SMO PMC2902748__F1 Hsp90-dependent modulation of proangiogenic signaling pathways in cancer EGF HGF EGFR SKI MTOR EPHA2 PMC10525272__F6 Platelet activation pathway confirmed in the KEGG pathway analysis VASP FYN DAO FRK F2 LYN PROC VWF ARHA SYK COMP SNAP23 PMC10525272__F5 Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds—A Preliminary Study PLN PI3 BCR CAV3 HRC MCU CAV2 TRDN PMC10525272__F4 Vascular smooth muscle contraction pathway confirmed in the KEGG pathway analysis PTGIR EDNRA AVP CNP ARHA CAD ADM PMC9371824__F12 Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury CD14 TLR4 LBP TRAF6 IRAK4 MAL PMC8062757__F1 Schematic diagram showing FST modulation of TGFB/Samd 3 signaling pathway during adipose browning FST MYF5 GDF11 PMC8418449__F4 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease TIGAR ME1 AASDH ARHA PHGDH HMGCR HEL-S-162eP HEL-S-26 F2 HEL-S-64p HEL107 HEL-S-133P LAT HEL-S-281 PMC10946270__F3 Classical and alternative pathways of NF-KB signalling are mediated by a variety of receptors and signalling molecules, including TLR, CD30L, CD40L, RANKL, etc CARD11 BCL10 IRAK1 RELB TRAF6 IRAK4 MYD88 PMC7064735__F3 Molecular mechanisms underlying PM2.5-induced defective airway epithelial host defense functions EGFR ASL PMC3164721__F1 Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome BRAF APC GRB2 PIK3CA RHO PTEN BAX FOXN1 PMC9172986__F6 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis F9 UTP4 POLL IMP3 NMD3 IMP4 PWP2 NHP2L1 NOP56 F2 VWF NHP2 UTP15 NOB1 POLI PMC9172986__F5 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis MOS MRPS16 SP4 HEL-S-92n POR SP1 NAPA PMC5067532__F3 Hydrogen sulfide in DN NOX4 MTOR PMC5389977__F3 Release of growth hormone (GH), Wnt, or RANKL, as stimulated by progesterone (P4), promotes interaction with various signal transduction pathways EGF LEF1 EGFR GHR PTEN MTOR TF PMC5335555__F6 CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGFB signaling PRDM14 SOX2 SMAD2 SRC PMC5389977__F4 Interaction of HER-activated pathways with canonical Wnt signaling MUC1 EGF HGF APC GSK3B SRC PTEN TF PMC4814376__F1 Summary of metabolic FGFs FGF21 FGFR1 FGF19 FGFR4 PMC9676213__F7 MS-proteomics provides insight into the host responses towards alginate microspheres TFPI CFB PLG MASP1 PROC HEL-S-92n C4A CLU CFI CFD CFH VTN CRP PMC9685611__F2 Ovarian cancer stem cells: Critical roles in anti-tumor immunity COX1 CD44 CTLA4 MYD88 PMC4176146__F1 The hexosamine biosynthetic pathway and O-GlcNAcylation are shown OGA OGT COCH PMC7434989__F2 Emerging roles for the IL-6 family of cytokines in pancreatic cancer SOCS3 GRB2 JAK1 STAT3 PMC7264916__F1 Mutations and signaling pathways in vascular anomalies MAP2K1 BMP10 PIK3CA ENG PTEN MTOR SMAD1 EPHB4 DKFZp781O1323 PDCD10 PMC8508931__F5 Comparative Phosphoproteomic Analysis Reveals the Response of Starch Metabolism to High-Temperature Stress in Rice Endosperm GPT PMC4331812__F5 Metabolic flux map of central carbon metabolism in cotyledons at early seed fill GNE HEL107 PAH MAL PMC3513650__F1 BRCA and RAD52 pathways of DNA double-strand break (DSB) repair PALB2 BRCA2 RAD50 RAD52 RAD51 MRE11A PMC8418449__F6 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease F2 DHFR ARHA HMGCR HEL-S-162eP PMC6600513__F1A Signal Exchange through Extracellular Vesicles in Neuromuscular Junction Establishment and Maintenance: From Physiology to Pathology MUSK LRP4 F2 APC PMC8071006__F6 Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model LAT2 CTRL SPACIA1 PMC3603147__F7 Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells OSR1 CIT PMC4833964__F1 Cancer-relevant pathway map MTOR PMC5406580__F2 Hypothalamic circuits regulating thermogenesis of BAT and browning of WAT POMC MPO NPY AgRP MC4R ARC LEPR PMC2922475__F1 CD73: A novel target for cancer immunotherapy ADA PMC6387609__F7 Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3B/Beta-catenin signal pathway GSK3B PMC5857625__F7 Schematic representation of murine and human gonadal androgen synthesis CYP11A1 POR CYP17A1 STAR HSD17B6 PMC8056114__F1 NGF-mediated regulation of the NGFR and NTRK1 signaling pathways NGF NGFR NTRK1 RHO CR2 CR1 LINGO1 PMC8805653__F1 IL-33/ST2 pathway and its conceptual role following ischemic stroke TLR4 IRAK1 IL33 TRAF6 IRAK4 MYD88 PMC5031419__F4 Non-overlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi KIT BAD BRAF MDM2 SRC CDK4 PTEN RB1 PMC6770591__F7 Scheme of the de novo synthesis pathway of glutathione CTH HEL-S-64p PMC6362810__F3 Multiple nonunidirectional levels through which autophagy-related processes in senescence affect regulation of SASP genes, often via NFkB activation IL10 IL1A TRAF3IP2 MTOR GATA4 PMC3873730__F3 Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging GGH NGF TTK S100A1 CDCA2 UBB SOX9 FZD9 COL11A2 MMP7 POLE2 POMC PRC1 LYL1 E2F2 COL9A2 NOTCH1 GDNF FGL2 CLEC3A MAL DBNDD1 c-fgr CKS2 ACTG2 FGF2 TACC3 PLK4 FGFR3 CEP55 FGF18 SKA3 ARHGAP15 UBE2C CDC20 ABTB2 GIG8 LIPA CCNB2 CKAP2 HEL-S-66 PCNA PMC7072559__F2 Metabolic pathways contributing to glutamine addiction in gliomas HEL-S-26 PC GPT MTOR PMC9511797__F2 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer PTEN PMC9511797__F1 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer S100P TRPC6 SGK1 PMC9313971__F1 Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated—A Systematic Review XPC XPA PCNA PMC9928209__F7 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug PTEN EIF4E GAL MTOR EIF4B PMC6280650__F1 Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches TBK1 CDA CGAS IRF3 PMC7701511__F3 VEGFA/VEGFR2 system differentially modulates the UPR activation in condition of transient or sustained ER stress EIF2A VEGFA PMC2672430__F2 Prodeath or Prosurvival: Two Facets of Hypoxia Inducible Factor-1 in Perinatal Brain Injury COX2 EPO IGF2 VHL BNIP3 PMC8127222__F1 Emerging role of the KCTD proteins in cancer SHH SMO KCTD15 HDAC1 PMC8127222__F2 Emerging role of the KCTD proteins in cancer TNFAIP1 KCTD1 BTBD10 KCTD20 APC KCTD10 KCTD12 GSK3B NOTCH1 PMC3046427__F2 Beta-Catenin is at the hub of multiple signaling pathways PIN1 HEL-S-28 EGFR APC GSK3B LRP5 LRP6 SKP1 SOX17 NLK PYGO2 FER SIAH1 ERBB2 SRC CCND1 EZH2 PMC9619051__F1 Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling EPO LIF STAT4 IL27 EGFR IL2 IL-21 TNF HIF1A OSM SOCS1 STAT3 PMC7799431__F1 Importance of Keeping Time in the Liver NAMPT SIRT6 RORA SIRT1 PMC2903563__F7 Glucose metabolic pathway response POC5 ENO1 ENO2 GPD2 GAD1 HEL-S-68p PMC11284857__F4 Depicted regions primarily reside within the dental follicle tissue surrounding the root apex PTCH1 TGFBR2 SMAD4 WNT10B PMC7012465__F2 Regulation of hepcidin expression (adapted from Silvestri et al.) ERFE BMP6 BMP2 SMAD4 TMPRSS6 HFE IL6 IL6R TFR2 TLR4 SMAD1 TF DKFZp781O1323 STAT3 PMC3871684__F1 Microfluidic Generated EGF-Gradients Induce Chemokinesis of Transplantable Retinal Progenitor Cells via the JAK/STAT and PI3Kinase Signaling Pathways PLCG1 EGF MAP3K1 MAP2K4 FOS EGFR MTOR PRKCA RPS6KB1 MAP2K1 SRC RAF1 JAK1 CR2 JUN SHC1 STAT3 PMC6098640__F5 The pathway through which IL-33 stimulates the proliferation signaling of CRC cells COX2 IL33 PMC4730337__F1 EGFR transactivation by GPCR EGFR GRB2 SRC HBEGF PMC7238533__F2 Role of Fbln7 and its C-terminal fragment in the modulation of cellular functions under physiological and pathological conditions STAT1 FBLN7 ARHA RAC1 STAT3 PMC7178193__F2 Adiponectin properties on healthy skeletal muscle ADIPOR1 IRS1 NR1C1 TF APPL1 PMC4900151__F1 The role of REDD1 in the regulating muscle protein balance in response to acute alcohol TSC2 ULK1 TSC1 RPS6 RHEB PMC4261235__F1 Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway PI3 PIR PTEN IRS1 PMC5542187__F5 Simplified diagrams of putative signaling pathways responsible for the different migration patterns (i.e MDM2 ARHA MTOR CDC42 PMC6315991__F1 Links between Lipid and Iron Metabolic Pathways HAMP STEAP3 ACACA EBP SC5D FES TM7SF2 HMGCR GPAM HEL-S-5 HEPH RP1 PCBP1 ACLY PMC3476325__F9 Proposed model for how CCL2 signaling through CCR2 signaling regulates survival and motility of breast cancer cells CCR2 ARHA CCL2 PMC4114208__F1 Unfolded protein response pathways are shown ATF4 XBP1 PMC11659389__F5 STRING protein‒protein interactions between the recognized proteins and our prioritized proteins for each skin cancer KRTAP10-9 BRAF CTSS NRAS TCHH CDKN2A MTAP SLC45A2 ASIP TLR7 CLPTM1L SUFU SHH SMO MC1R CSA2 KRT1 SYP LTBR ROS1 KRT14 TERT PMC8236816__F2 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models VPS35 LRRK2 RAB10 PMC8236816__F1 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models VPS35 LRRK2 ATG9A HEL-S-130P RAB7L1 PMC2786705__F8 Continued defect in IRF-3-deficient BMDCs STAT1 STAT2 IRF3 PMC6381377__F6 Deregulated Wnt signaling pathways in the BM of ENU induced experimental leukemic mice WNT3A CCND1 ROR2 DKK1 CDH2 PMC4227184__F10 Pathway analysis PAK1 CS VCAM1 EGFR VAV1 VEGFA RAC1 HRAS JUN PDPK1 PMC11064393__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC6757413__F4 Important signaling pathways that govern the differentiation of pancreatic conversion and the mechanism of action of different small molecules and peptides reported on pancreatic differentiation from MSC EGF HGF NODAL APC EGFR APP MTOR PMC10389822__F2 Intersection of COVID-19 and Rheumatoid Arthritis: Shared Mechanisms, Treatment Challenges, and Potential Therapeutic Approaches RELA STAT3 BRD4 PMC8284093__F11 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney JMY RB1 TFDP1 E2F3 CCNI TADA2B NR1i1 MMP2 APAF1 TNFRSF10D HTT BNIP3L SP1 PRKAB1 TP53BP2 COL18A1 BAK1 TP63 APC DDB2 CASP10 BCL2L14 POU4F2 TSC2 DUSP5 BCL2A1 POU4F1 CEBPZ BCL2 SESN1 TNFRSF10A HSPA1A TGFA HIC1 PCNA TIGAR CASP6 AFP SCN3B GPX1 PCBP4 RCHY1 FOXA1 opn TYRP1 NFYB NFYA ARID3A PLK3 BCL2L2 BCL6 PRMT1 CREBBP EP300 KAT2A RGCC EPHA2 TAF9 DKK1 TP53INP1 SMARCA4 AIFM2 PERP MDM2 NFYC HDAC2 MSH2 BTG2 FDXR ZNF385A CD82 ATF3 SH2D1A DDIT4 HEL-S-31 RNF144B TRIAP1 TP73 PML PPM1J HGF SFN EGFR TRRAP PTEN CCNC E2F2 CCNB1 DDX5 JUN BAX DGCR8 LIF DROSHA HEL-S-130P PMS2 RRM2B BBC3 PMAIP1 PIDD1 EDN2 MCL1 TNFRSF10B PMC3787304__F1 Different phosphorylation sites on STAT3 mediate canonical and non-canonical functions of the Notch signaling pathway HES5 HES3 GFAP STAT3 HES1 PMC8284093__F10 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney MYC PIGS PTEN RFWD2 TSC2 CASP3 AIFM2 PERP ATM CDK2 CD2 MDM2 CASP9 ATR SIVA1 BAX PMC6895278__F4 Models for REV3-dependent synthesis at difficult-to-replicate regions in the genome RAD52 RAD51 PCNA PMC8006921__F7 Wnt signaling gene expression profiling in healthy versus asthmatic bronchial fibroblasts generated by PathViso pathway analysis and drawing software NFATC2 FOS INS ARHA POR PSCA PMC11855906__F4 Mechanistic insights and multifaceted applications of autophagy as a potential therapeutic target for metabolic cardiomyopathies PINK1 NAMPT ULK1 RIPK1 RTN3 FTH1 EIF5A BCL2 METRNL ALDH2 STAT3 SEC62 PMC11855906__F3 Simplified scheme for the regulation of cardiac selective autophagy in HFD-induced metabolic cardiomyopathy ULK1 TFEB PLG RTN3 STAT3 SEC62 BRD4 PMC6759601__F5 Schematic overview of gene expression regulation of fatty acid oxidation and tricarboxylic acid (TCA) cycle in tPVAT and IAT CS HEL-S-32 MDH2 ACADS FH MDH1B OGDH SUCLG2 SDHD SDHA SDHB SLC25A20 SDHC SDHAF1 DLD IDH3B TG ACADL ACADVL SUCLG1 PECR SUCLA2 SDHAF2 EHHADH LAT ACADM PMC11855906__F2 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in STZ-induced metabolic cardiomyopathy ULK1 RIPK1 LAMP2 BCL2 MTOR NRG4 METRNL FOXO1 PMC6830338__F1 Transcription regulators (TRs) that modulate glycolytic metabolism in cancer cells TIGAR PARP14 PTEN MTOR HEL-S-162eP PMC11855906__F1 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in HFD-induced metabolic cardiomyopathy ULK1 ATG12 BCL2 MTOR DKFZp686F0183 ALDH2 PMC7714584__F6 Target-pathway network MMP3 CXCL10 PTGS2 opn MMP9 HSD3B2 ABCG2 IL1B CXCL11 PMC8863938__F2 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BAD MEI1 BAX PMC6707069__F8 Influence of extracellular HA in erlotinib efficacy using a reductionist 3D glioblastoma model EGFR CD44 PTEN STAT3 PMC5387055__F3 Upon antigen encounter T cells differentiate into effector cells PLCG1 MYC CTLA4 HIF1A MTOR PMC8863938__F4 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BCL2 MTOR BAX PMC8863938__F3 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers ATF4 EIF2A BCL2 BAX PMC8863938__F5 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers CSA2 BAX PMC7267729__F5 Dysregulation of the Myostatin Pathway in Mtm1−/y MiceThe members of the myostatin pathway analyzed in this manuscript at the mRNA or protein levels are indicated in this figure SMAD2 MSTN GDF11 PMC1435694__F1 Chemistry of the retinoid cycle reactions in the vertebrate retina RPE65 RGR RPE PMC8063466__F4 Quercetin inhibits overactivation of dormant PMFs induced by Cy AMH RPS6 MTOR PMC9252958__F1 Contribution of specific ceramides to obesity-associated metabolic diseases SGPP1 DGAT2 CER1 DES UGT8 HEL-S-5 ACSL5 CERS3 SGPL1 LASS1 CERS5 SMS KDSR CERS2 CERS6 PMC5403850__F1 Pathological effects of chronic oxidative stress TH IRS1 CD36 PMC5502164__F1 Methylation cycle pathway: (A) Methionine and homocysteine (Hcys) are generated by the following enzymes: CBS = cystathionine Beta-synthase, MAT = methionine adenosyltransferase, MS = methionine synthase, SAHH = S-adenosylhomocysteine hydrolasa VIT HEL-S-20 PMC9586738__F1 Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine ALDOB F2 HEL-S-87p MTOR HEL-S-133P HEL-S-281 HEL-S-162eP PMC7795614__F3A Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action RCC1 RAN PMC9687454__F2 Tirzepatide—Friend or Foe in Diabetic Cancer Patients? IGF1R IGF1 GIPR MTOR PMC5477726__F1 BMP4 signaling pathways NOG BMPR2 BMPR1A SMAD6 SMAD4 SMAD1 DKFZp781O1323 BMP4 PMC3968382__F1 New anti-complement drugs: not so far away HEL-S-62p CD59 PMC12112211__F6 Activation of T cells by dendritic cells in lymph nodes; (B) binding of T cells to tumor cells inducing apoptosis; (C) signaling pathways for activation of cell growth and proliferation or signaling pathways for cycle arrest or apoptosis STAT1 TSC2 TSC1 APC MDM2 CASP9 CD80 PTEN CASP2 TNF CASP8 FADD PMC5095497__F7 Role of the citrate pathway in Down syndrome (DS) SLC25A20 CIC ACLY PMC3195227__F1 A schematic diagram of the kynurenine pathway HEL-S-90n KYNU KMO PMC8959454__F1 Drug Discovery of DKK1 Inhibitors CKAP4 ATF2 APC ARHA DKK1 JUN PMC3342334__F9 Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway TSC2 TSC1 ARC EIF4E RHEB PMC4138453__F3 Metabolic pathway of arachidonic acid via 5- lipoxygenase GHB3 LTA LTB PMC3357406__F3 Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development ASF1B BLM BAG4 SMAD2 JAG2 MAPK14 UMPS PITPNB SH3RF1 MPHOSPH9 KPNA1 TNFRSF13C KPNA4 LGALS7B PNKD MSH6 ECSIT IGSF8 BRIP1 SNX5 SLC25A4 LSG1 DAPK2 APEH HNF4A CDC42EP3 ATP13A3 STAT4 CNBP SIAH2 TGFB1 BRD4 PMC7827855__F1 Interplay between the Hippo, Wnt and ARF/p53 signaling pathways in development and tumorigenesis ATM FOXM1 APC MDM2 LATS1 LATS2 PMC3410580__F6 p62/SQSTM1 acts either as a pro-oncogene or as a tumor suppressor protein CYLD APC TRAF6 MTOR PMC3410580__F2 Structure and interacting partners of p62/SQSTM1 KEAP1 TRAF6 MTOR NBR1 PMC4943213__F1 Wnt signaling APC GSK3B PMC9599635__F1 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies TBP TF PMC3363966__F4 Components and targets of pro-phenol oxidase, Toll-Dorsal/Dif and JAK/STAT pathways DDC TEP1 MYD88 TRAF2 PMC3058199__F6 Noonan syndrome and clinically related disorders CS BRAF GRB2 SPRED1 SHOC2 RAF1 SOS1 HRAS CBL PMC9599635__F2 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies TBP REST SIN3A BDNF TF PMC5859860__F2 Proposed model of cross-regulation between LAP and canonical autophagy in p47phox−/− mice C6 PMC6739980__F3 Summary of ventral midline crossing BOC ROBO3 SHH ROBO1 DCC PMC9026123__F1 Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease TPMT NUDT15 PMC5398309__F2 Visible model is an excerpt of the KEGG (Kyoto Encyclopedia of Genes and Genomes) FoxO signaling pathway in humans as appears after importing in bStyle NLK PRMT1 IGF1R IGF1 CDK2 MDM2 INS SMAD4 PTEN SKP2 INSR STAT3 PMC3078187__F1 Signaling Cell Death from the Endoplasmic Reticulum Stress Response ATF4 EIF2A MCL1 BAX PMC7724774__F1 PD-L1 expression through NFKB MUC1 EGFR PMC2894370__F4 “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology TSC2 VHL PTEN HIF1A MTOR RHEB PMC6399501__F3 Disorders resulting from mutational defects in the lysosomal SL degradation pathway GM2A GLB1 HEXA SMPD1 PSAP HEL-S-111 GLA PMC2825767__F2 Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse SQLE PMVK MVD DHCR7 FDPS FDFT1 SC5D MVK IDI1 HMGCR PMC2825767__F1 Adrenal insulin signaling and glucose transport gene expression is overexpressed in the chromogranin A (Chga) knockout mouse PRKCZ SOCS3 CAP1 MAP3K11 SOST MAPK3 GSK3B TRIB3 MAPK14 MAP2K6 PDPK1 PRKCA FLOT1 MAPK1 PRKCI MAP3K1 PRKCQ SOS2 FOS MAPK7 MAP3K7 RRAD MAP2K5 MAP3K5 SH2B2 CRK HEL-S-31 SNAP23 FOXO1 RHEB TSC2 SHC2 GYS2 PPP1CC TSC1 VAMP2 RPS6KB2 GRB2 MAP3K14 PRKCH ENPP1 MAP2K4 GYG1 PTEN MAP2K3 SHC3 XBP1 MAP4K1 INSR MAP4K3 PTPN1 PTPN11 JUN INPPL1 IRS4 GRB14 MAP3K6 PRKAA2 STXBP3 STXBP4 EHD1 STXBP1 EHD2 KIF3A RAB4A MAP3K10 GYS1 RAC1 MAP3K13 SNAP25 TBC1D4 MAP3K12 ARF1 PIK3C2G PTPRF FLOT2 PIK3R4 CBL IKBKB MAP4K2 MINK1 RPS6KB1 LIPE SGK2 MAPK6 SLC2A4 MAPK4 MAP3K2 HEL-S-42 PIK3CA MAP3K8 GRB10 PIK3R2 PMC5953777__F3 Cancer-relevant signaling pathways BAD ROCK1 CSA2 CAD CP BAX PMC2825767__F3 Hepatic cholesterol biosynthesis pathway gene expression is globally overexpressed in the Chga knockout mouse SQLE PMVK MVD DHCR7 FDPS FDFT1 SC5D MVK HMGCR PMC9652939__F9 MICAL1 facilitates pancreatic cancer proliferation, migration, and invasion by activating WNT/Beta-catenin pathway APC GSK3B AXIN1 FZD7 MICAL1 PMC5953777__F2 Connectivity of differentially expressed genes in the important cancer signaling pathways in the exposed children are shown according to gene expression levels (with ≥ 1.5-fold change, t test, p < 0.05) NFKB2 MYC CP PMC10995750__F3 Genes enriched in plasma membrane estrogen receptor signalling pathway c-fgr RUNX1 NCOR1 CSNK2A1 FOS NCOA6 TRRAP RB1 CCND3 BAG1 STAT1 SMARCA4 NR1i1 POU2F1 GRB2 PPP2CA NCOA1 JUN PMC3599951__F5 Phytochemicals targeting NFkB signaling pathway BAD PTEN PMC10540768__F2 Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease HEL-S-62p C9 MASP1 C6 MASP2 C1S C4A PMC4027049__F2 TGFB signalling in context BMPR2 DROSHA TGFBR2 SMAD4 TRAF6 ARHA RHO PMC5466034__F10 A Putative Model of Central Carbon and Energy Metabolism in Tomato GTs.A type VI glandular cell with its plasma membrane as a black line C6 CIT IPP MAL PMC9367255__F2 Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy TLR7 ATG3 TRAF6 DKFZp686F0183 PMC8690896__F1 E-cadherin on epithelial–mesenchymal transition in thyroid cancer BRAF DPP4 CXCR4 EGFR PTEN CXCL12 TNF MTOR PMC2749270__F1 Sphingosine-1-phosphate synthesis and functions in mast cells FYN LYN SPHK1 SPHK2 PMC3261582__F1 JNK signaling enhances the compensatory proliferation of the neighboring cells, stem cells or cancer stem cells (CSCs) SOX2 MYC KLF4 CD44 CCND1 PMC6399501__F2 Mechanisms of pathogenesis of inborn errors of SL metabolism SPTLC1 UGCG CERS3 SGPL1 SPTLC2 HEL-S-111 KDSR PMC6399501__F1 Disorders resulting from mutational defects in the SL synthesis pathway for ceramide and GSLs and the nonlysosomal SL degradation pathway SPTLC1 ORMDL3 UGCG CERS3 SGPL1 ACER3 B4GALNT1 LASS1 SPTLC2 KDSR ST3GAL5 PMC12055549__F0 Proposed signaling pathway of tetramethylpyrazine (TMPZ) in protecting against acute pancreatitis through inhibition of pyroptosis via the NRF2 pathway NLRP3 GSDMD PMC7906182__F4 Interacting networks between coiled-coil domain-containing protein 167 (CCDC167) and micro (mi)RNA GAD2 IGF1R RUNX2 BMP2 SMAD2 MMP9 HOXA2 HEL-S-26 NOG AGO2 MMP2 ATF4 PKD1 SFRP1 SP1 PMC3012182__F1 TRPM channels in insulin secretion TRPM2 TRPM5 MLSN2 PMC7906182__F3 MetaCore pathway analysis of coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer patient databases TCP1 CDC20 CS RASSF1 PLK1 CDK2 APC CDC2 SKP2 PMC8624906__F2 Transcriptional Regulation of Ripening in Chili Pepper Fruits (Capsicum spp.) MYB CCS PMC199181__F2 Proposed mechanisms of NFKB activation in HIV-1–infected cells TRAF2 FADD PMC7772706__F3A Based on network pharmacology method to discovered the targets and therapeutic mechanism of Paederia scandens against nonalcoholic fatty liver disease in chicken NAIP TRADD SP2 AHI-1 MYC RALA TRAF6 ARHA RILP AHNAK HEL-S-162eP NLRP3 MAFK SKI SP1 IL1B FADD TIRAP PMC199181__F3 The NFKB pathway by viruses TRADD TNF TRAF2 PMC4425424__F3 Transcriptional regulation of cranial sensory placode development ZIC1 MSX1 FOXI1 PMC6124012__F6 Sterol regulatory element-binding protein 1 signaling DHCR7 LDLR FASN PMC11414398__F7 Alternative Src regulatory pathway mediated by the METTL18-RPL3-HSP90-actin axis in HER2-negative breast cancers METTL18 SRC RPL3 PMC6406790__F1 The schematic diagram represents the treatment schedule and the mechanism of NAM neuroprotection in mouse brains CASP3 BCL2 IL1B BAX PMC11023816__F9 Proposed pathways by which paracrine and autocrine cytokine signaling modulates vitamin A metabolism across stellate cell activation phenotypes RARB LRAT TLR4 CRABP2 RBP4 MYD88 TRAF2 IL6R PMC8771518__F7 Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis NLRP3 IL1B GSDMD PMC7415260__F4 Signaling pathway visualization based on changed protein and transcript expression of SYN1, SYN2, SYN3, SNAP25, STX1A, RAB3A, and STMN1 in recurrent samples VAMP2 SYN2 STX1A SYN1 SNAP25 PMC3544784__F1 Insight into the role of CRMP2 (collapsin response mediator protein 2) in T lymphocyte migration CXCR4 GSK3B CDK5 CXCL12 PMC2387183__F4 Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling GIG8 IGF1 ID4 BMP2 FOSB SMAD6 PMC9424640__F7 Therapeutic potential of NR4A1 in cancer: Focus on metabolism COX2 MSC CD34 PMC11786761__F9 SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway BCL2 SH2B1 BAX PMC5453624__F5 Comparison of the adolescent and adult mouse prefrontal cortex proteome DLGAP1 ARHGEF7 PPP3CA GSTM5 STXBP1 PTBP1 DPYSL3 BDH1 EIF2AK2 MTOR GAP43 LPAR1 CRMP1 UQCRC2 HEL-S-162eP CNTF NTF4 RICTOR ATXN1 ZDHHC8 FABP5 BDNF CPLX2 PMC3791178__F1 The Autophagy Pathway by Human Tumor Viruses ATG12 ATG3 MTOR DKFZp686F0183 PMC11023816__F1 Vitamin A metabolic pathway and the enzymes involved in retinoid metabolic flux in human liver PNPLA3 CYP26A1 LRAT CYP26B1 CRABP2 CYP1B1 RBP4 HEL-S-53e CRABP1 RDH10 ALDH1A2 RDH11 PMC5453624__F7 Comparison of the adolescent and adult mouse prefrontal cortex proteome TH SNCA CLTA HEL-S-30 MBP HEL-S-15 PTEN FMR1 KNS2 RANBP9 HEL-S-162eP ADORA2A PSEN1 APP ENO2 NOS2 PPARG CAMK2A CPLX2 PMC8939123__F1 Sirtuin family members in chronic obstructive pulmonary disease NLRP3 SIRT2 SIRT7 SIRT4 SIRT6 PGC STAT3 PMC4163877__F2 Integrated signaling networks and tumor cellular bioenergetics TSC2 TSC1 AAMP MTOR PMC11985700__F1 Key signalling pathways involved in muscle atrophy and hypertrophy TSC2 TSC1 IGF1 SMAD2 REST MTOR RHEB PMC3988951__F6 Insights into TREM2-related signaling using data-driven network constructions and information provided by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis HEL-S-62p VASP LAPTM5 SYK GPR34 CYBB DOCK2 ARF6 LAT TOB2 PMC7139637__F4 YAP drug targets SRC LATS1 LATS2 BRD4 PMC4433473__F4 Surface Fzd density by R-spondin-LGR5-RNF43 ZNRF3 RNF43 APC LRP5 LRP6 TCF4 PMC8877508__F1 Relevance of TLR8 in Viral Infections TLR8 TLR7 IRF7 TRAF6 IRF3 MYD88 PMC7139637__F3 Crosstalk between YAP signaling pathway and both TEAD and TGFB pathways SMAD2 SMAD4 TBR1 LATS1 LATS2 PMC4433473__F3 Ligand-dependent LRP6 endocytosis LRP5 LRP6 DKK1 TCF4 PMC7218640__F1 CRNDE significantly promotes cell proliferation through mediating multiple signaling pathways and various target genes IRX5 GSK3B PIWIL4 HNRNPUL2 CCL18 MTOR E2F3 TCF4 STAT3 PMC4759558__F12 CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone CMKLR1 STAR BMP4 PMC7139637__F1 Hippo/yes-associated protein (YAP) signaling pathway in mammals BIRC5 NF2 LATS1 LATS2 PMC8197279__F2 Damage-Associated Molecular Patterns Modulation by microRNA: Relevance on Immunogenic Cell Death and Cancer Treatment Outcome HMGB1 PMC3049335__F1 The Nrf2 pathway in PD pathogenesis MAF KEAP1 PRX TFAM NQO1 PMC6356367__F3 Upstream factors of the TOR pathway EGF EGFR RHEB PMC5525309__F1 Innate immunity TLR8 TLR7 TLR4 TLR9 CSK APC TLR1 TLR3 PMC6549764__F3 15d-PGJ2 regulates adipocyte differentiation and osteoblast differentiation via a PPARGamma-dependent pathway RUNX2 MSC PMC8194229__F3 Novel method to identify gene interaction patterns KIF1B VPS54 KIF12 KIF3B KIF1A COPA TMF1 KIFAP3 SEC24C SCN7A TFG DCT ARF3 KIF3C GBF1 DCTN4 STX18 BICD2 KIF3A VAMP4 COG2 RAB6B NAPA SPTA1 GORASP1 SEC16A SPTBN2 CPA4 COPE SEC22A NAPG PMC7395429__F7 Proposed model for MBP-induced abnormal cell growth of juvenile SCs IRAK1 MBP CDC2 PMC7663205__F2 Role of PITPNM3 in cancer cell migration PITPNM3 VCAM1 GSK3B CCL18 MTOR PMC7894993__F2 Extrinsic and intrinsic factors that regulate self-renewal in embryonic and adult haematopoiesis LIN28B ITGAM ATF4 SPRED1 GFI1 EZH2 EZH1 SOX17 MPL TET2 PMC6496801__F4 The primary molecular pathways leading to pyroptosis in monocytes/macrophages in CVDs NLRP3 GSDMD CD36 PMC11043957__F2 Nrf-2 and signaling pathways SMAD2 SMAD4 CSA2 MAP3K7IP1 NQO1 PMC11043957__F1 Signaling pathways in radiation-induced lung injury SMAD2 IGFBP7 SMAD4 PMC6496801__F2 Multiple pathways that mediate pyroptosis IRF7 IRF9 NLRP12 TRAF6 BRCC3 ARHA MYD88 GSDMD NLRP3 TLR4 TYK2 TXNIP AIM2 FADD PMC6496801__F1 Caspase‐1–dependent and independent pyroptotic pathway NLRP3 RHO AIM2 GSDMD PMC10875826__F1 (i) ERBB/HER family members and their cognate ligands (ii) Structural difference of various (I-VI) types of NRG1 TSC2 NRG3 EGF NRG2 HBEGF NRG1 NRG4 RHEB PMC8305013__F1 Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention KIT DCT PMC7550420__F2 Process and regulation of STING trafficking TBK1 MTMR3 YIPF5 IRF3 ATG9A MTMR4 SNX8 PMC7550420__F1 Diagram of STING-mediated immune response to viruses TBK1 CGAS IRF3 PMC100005__F11 Formation of TrkA–src-aPKC complexes FRS2 SRC TRAF6 PMC7185083__F5 PTEN may regulate autophagy by allowing for a bypass of PTEN/PRAS40 signaling in TSC2-/- cells and influence cell proliferation TSC2 TSC1 PTEN RHEB PMC7559772__F2 Genetic regulation of cell fate and size of the progenitor zone TPH1 CDK2 PMC6386770__F1 Differences in the functional impact of IL-7/IL-7R-mediated signaling in T-ALL cells and their normal counterparts JAK3 JAK1 MTOR BCL6 PMC5525309__F6 Working model of metabolic risk factor-induced two-way stimulatory immune checkpoint amplification and systemic/tissue inflammation APC LPL CD40 STAT3 PMC8113818__F2 Unfolded protein response (UPR), autophagy and coronavirus (CoV) infections ATG14 DKFZp686F0183 PMC8511434__F4 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction NLRP3 RUNX3 STAT4 LCN2 FFAR2 TNF STAT3 PMC5951756__F4 Insulin/IGF-1 signalling map FOXO4 IGF1R BAD CAP1 GSK3B PTEN MTOR INSR CAP2 EXOC7 FRS2 CAV2 EIF4B RAPGEF1 IRS4 EHD1 GSK3A EIF4E SH2B2 CRK IRS1 FOXO1 RHEB CBL TSC2 RPS6KB1 TSC1 IGF1 GAB2 GRB2 ACLY SOS1 SHC1 CDC42 AKT3 PMC8511434__F6 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction VIT NR1i1 CCR6 VIPR2 MTOR IL1B VIP STAT3 PMC4715089__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC4192457__F2 Signaling pathway regulation of autophagy by several factors ULK1 UVRAG BNIP3 MTOR ATG14 PMC3562679__F1 Lipopolysaccharide (endotoxin) signaling pathway CD14 TLR4 LBP TRAF6 MYD88 PMC3527539__F7 Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells EGF SMAD2 EGFR CCND1 TCF4 PMC3709966__F4 HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis HEL-S-99n ILF3 RHO MYH1 HSD17B10 ACTG1 TAGLN STOML2 PMC8650317__F1 Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts AHR TRO PMC3906243__F6 Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets FH CHDH DHFR PMC10245950__F9 ß-oxidation pathway for fatty acids is strongly downregulated by oxaliplatin ACAT1 HADHB C6 ACSL1 CPT2 OGDH ECHS1 PMC4816150__F2 Adiponectin signal transduction pathway implicating a crosstalk with the insulin signaling pathway MTOR IRS1 APPL1 PMC7970116__F3 Genomic characteristics of ccRCC for manipulating the TIME CXCL10 VHL PTEN CCL2 ARG1 IFNG POLI PMC11787754__F8 EA treatment might activate the mitophagy-related PINK1/Parkin signaling pathway through lncRNA-XR_002789763 PINK1 MFN2 OPTN PARL PMC7970116__F2 Bidirectional Relationship between targeted therapies (VEGF/VEGFR inhibitors) and TIME in ccRCC CCR2 CXCR4 FGF2 IL8RB CCL2 CXCL12 PMC5977762__F2 Up-regulation of the JAK-STAT and mTOR pathways: Ingenuity pathway maps for a JAK-STAT signaling (transducing extracellular signals to transcriptional responses) and b mTOR signaling (a master regulator for many fundamental cellular repair processes) TSC2 PC REN DAO INS IL4 GAST PMC7970116__F1 Mechanisms influencing immunotherapy response in the TIME in ccRCC ADA LAG3 ARG1 PMC4102648__F2 UV signaling pathways within the skin PDE4D TYRP1 MC1R PMC11787754__F1 PINK1-dependent mitophagy PINK1 MFN2 OPTN PARL PMC9385636__F7 Salidroside alleviates hepatic ischemia–reperfusion injury during liver transplant in rat through regulating TLR-4/NFKB/NLRP3 inflammatory pathway NLRP3 MYD88 IL1B PMC9406578__F2 Targeting Heat-Shock Protein 90 in Cancer: An Update on Combination Therapy ATM HEL-S-28 STAT3 PMC6482176__F1 The Insulin Signalling Pathway and insulin resistance PTEN IRS1 RAB10 PMC9043866__F8 TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NFKB pathway CASP3 IL1B BAX PMC3251736__F2 Ingenuity pathway analysis (IPA) of the EGFR ablation signature with oncogenic (A) and wildtype Ras (B) CXCL1 CD46 SP2 DUSP9 SMAD2 IL17F PIGR SSTR4 CR1 MATK KIF11 GCGR VPS13A GIG8 HNF4A GOLIM4 CDC6 TIMP3 TMPRSS11E INHBB MYLK3 HABP2 PMC7729585__F2 Fatty acid metabolism, glycolysis, and tricarboxylic acid cycle (TCA) cycle ALDOB HEL-S-26 PDC SDHC ME2 PDK3 PDK2 CPT2 PDK4 PPT1 MCAT PMC4858538__F4 Role of p38 MAPK in Wnt signaling GSK3B LRP5 LRP6 DVL1 TCF4 PMC9109300__F7 Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1 HDAC3 SMAD2 SMAD4 PMC5329966__F3 Heterogeneous responses of normal and malignant B cells upon CpG ODNs stimulation STAT1 TLR9 IRAK1 TRAF6 IRAK4 CD80 MYD88 BAX PMC10143138__F2 Osteoblast cellular cholesterol homeostasis LDLR TG HMGCR PMC6917641__F1 Drugs with clinical potential in cancer that modulate miRNAs implicated in cell metabolism ZEB2 GABPA SIX1 NR3B3 SP1 MTOR IRS1 HK2 PMC9563854__F3 Natural antisense transcripts as drug targets USP14 SMURF2 MDM2 PMC10253382__F3 Anti-inflammatory pathways induced by baicalin NLRP3 HMGB1 TLR4 SOCS3 GSK3B FOXO1 PMC8841999__F1 ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets SEL1L APOB CCPG1 TEX264 ATL3 STX17 VAMP8 UFD1L CYP2E1 SEC62 PMC5748990__F2 Pathways regulating senescence-mediated arrest MDM2 CDK4 CDK6 PMC4403295__F2 ER-mitochondrion tethering MFN1 NLRP3 PML VAPB MFN2 PTEN FIS1 PMC8207264__F6 Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8− Positive (AT8+) Tau in Alzheimer’s Disease MTRR OTC CIT HEL-S-20 ASL PMC4403295__F1 The UPR signaling pathway ELF2 ATF4 XBP1 PMC9029304__F1 Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications TSC2 TSC1 CCND1 MTOR IRS1 PMC6169995__F3 Differential targeting of genes in the drug metabolism pathway GSTA4 ALDH3B1 MAOA FMO4 UGT2B15 MGST2 GSTT1 AOX1 GSTZ1 CYP2C18 GSTT2 GSTM4 GSTM3 ADH1C HEL-S-117 CYP2B6 UGT1A3 LOC51064 GSTM5 PURA GSTM1 MGST3 ADH5 ALDH3B2 HEL-S-21 HEL-S-22 GSTM2 MGST1 CYP3A4 ALDH1A3 ALDH3A1 PMC8875462__F4 Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice BAMBI INVS CBY1 APC SOST NOTUM CER1 SMAD4 SKP1 RYK ARHA GPR49 RBX1 LGR6 NLK MMP7 SIAH1 PMC6277637__F3 Main brain-immune system pathways and feedback loops illustrating the interconnected effects of physical and emotional stress in health TRH CRP AVP PMC9136512__F10 CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth CHEK2 RPL26 CDC2 CDK5RAP3 MTOR CHEK1 BAX PMC4772904__F1 NSAIDs inhibit PGE2-induced tumorigenesis through targeting multiple downstream signaling pathways of PGE2 COX1 EGFR GSK3B PMC8353915__F6 VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines MAX USP14 ATF4 EIF2A ADA XBP1 PMC3495983__F6 Model illustrating CD40-induced signals that mediate the expression of VEGF in endothelial cells RICTOR CD40 MTOR MLST8 PMC4786283__F2 Stability of Ensemble Models Predicts Productivity of Enzymatic Systems TTK HEL107 EN1 RPE PMC8310438__F1 Corrigendum to “Expression and Gene Regulation Network of Metabolic Enzyme Phosphoglycerate Mutase Enzyme 1 in Breast Cancer Based on Data Mining” TIGAR CHUK HEL-S-30 PGAM4 HEL-S-87p HSD17B10 HEL-S-162eP HEL-S-49 AP2M1 MDM2 TYMS PFKP HEL-S-133P PGAM2 PMC11465581__F8 The effect of neuroinvasion on immune tolerance in NSCLC NGF released from NSCLC cells induces neuronal cell differentiation and axonogenesis in the tumor microenvironment (TME) NGF MTOR HTR1D PMC9611604__F7 How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status? AHR CYP1A1 IFNG PMC5608833__F10 Rep-MYB-mediated repression of G2/M-specific genes under DNA stress conditions MYB ATM ATR PMC3942330__F6 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms EPHB1 TNIK KSR1 ARHA RAP2C RAF1 RAP2A PMC3942330__F5 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms EGFR SRC SH3BP1 CD2AP CDC42 VAV2 PMC3000836__F1 Comparison of the DC-ATLAS Toll Like Receptor (TLR) 3 pathway with other pathway databases EFS CD14 CDA CD40 IRAK4 IL6 TNF tal-1 TIRAP PTER PMC3942330__F4 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms CASP3 EGF EGFR CASP9 SRC RAC1 PMC6281690__F4 Schematic illustration representing metabolic and transport proteins hypothesized from the genome of Ca INA AGA FH RGR PMC3519537__F5 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing EEF2K RICTOR TSC1 PTEN RPS6 RHEB PMC3942330__F3 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms ROCK2 CASP3 ROCK1 CXCR4 ARHA CXCL12 ARHGEF11 PMC6305103__F2 Tumor metabolism regulating chemosensitivity in ovarian cancer TIGAR BRAF HEL-S-30 MYC PTEN LPA HEL-S-162eP PMC6823874__F1 Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response POLE POR POLI PMC10309183__F4 Ether lipids and a peroxisomal riddle in sperm GNPAT HMFN0839 DHRS7B GPAT4 FAR1 GPAT2 PMC11393989__F1 Molecular and cellular mechanisms of TGFB signaling pathway in GO SMAD2 LRP5 SMAD4 NOX4 LRP6 ARHA FZD4 DVL1 SOX9 PMC3942330__F8 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms ARFRP1 SRC ARF6 ARF1 GBF1 PMC6920345__F3 The impact of oncogenic RAS on redox balance and implications for cancer development GCLC ATF4 MYC HMOX1 JUN ACSL3 MAL PMC3855668__F1 Model of the signaling pathway mediated by ATM in response to DSBs induced by IR, as proposed by Kitagawa et al ATM MDM2 RAD50 H2AX MRE11A BRCA1 PMC3519537__F1 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing EEF2K RICTOR AGA DCP2 DST MYC CASK RHEB PMC11826106__F9 CSRP2 inhibits the necroptosis of glioma cells by activating the JAK-STAT1 signaling pathway STAT1 RIPK1 CSRP2 PIAS1 RIPK3 MLKL PMC4371597__F1 Evaluation of the Unfolded Protein Response: PI 3-Kinase Regulatory Subunits as Regulators of the IRE1A Pathway ATF4 EIF2A PMC8043893__F9 SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation CARMIL2 SKI LATS2 LIMD1 PMC3123739__F8 DNA Repair Deficiency in Neurodegeneration FEN1 RNF8 ATM BLM MDC1 RAD52 TPO RAD51 LIG1 XRCC3 WRN TDP1 PMC4417967__F2 Relative adenine and thymine (%AT) DNA content of ergot alkaloid synthesis (EAS) loci AFP F11 CDC45 PRL PMC7521342__F5 Global gene expression analyses of the alkamide-producing plant Heliopsis longipes supports a polyketide synthase-mediated biosynthesis pathway AFF4 AFF1 AFF2 PMC5260500__F3 DAB2IP in TNFA signaling: activation of ASK1/JNK TRADD DAB2IP CSA2 TNF TRAF2 PMC8061373__F1 Schematic hypothesis of the proposed mechanisms of TLR3 derived from SARS-CoV-2 leading to hypertension TBK1 IRF3 STRAP ACE2 TLR3 PMC7062180__F1 A, the mammalian polyamine metabolic pathway SMOX SRM PAOX SMS PMC9592233__F5 Lipid Profiling of Pacific Abalone (Haliotis discus hannai) at Different Developmental Stages Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry PC LPA TG PMC2798676__F10 Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling SCARA5 MMP9 GRB2 CCND1 SRC RHO CRK CDC42 PMC1829400__F5 TGFB signaling pathway NOG DCN MYC PMC12072309__F1 Schematic illustration depicting the dysregulation of the NF2/Merlin-Hippo signaling cascade in mesothelioma cells YAP1 AJUBA LATS1 LATS2 PMC4581967__F1 Evasion and Interactions of the Humoral Innate Immune Response in Pathogen Invasion, Autoimmune Disease, and Cancer CS MASP1 C7 C6 C4A PMC8452443__F3 Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis APC CCR7 CXCR5 KLF2 FOXO1 ICOS BCL6 PMC8391678__F2 LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases ROCK2 PAK1 LIMK1 RAC3 RHO RAC1 BDNF PMC10955039__F6 Hippo signalling pathway in ferroptosis GPX4 ANGPTL4 FACL4 SLC7A11 NOX4 EMP1 PMC2649808__F5 Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions GRB2 GOPC MTOR CRK CBL HEL-S-5 PMC3387654__F1 Mammalian Hippo pathway and cancer NF2 LATS1 LATS2 PMC7965781__F1 Control of the insect metamorphic transition by ecdysteroid production and secretion HEL-S-62p SHD C6 PMC6966089__F2 Methanol condensation cycle (MCC) for assimilation of methanol into higher alcohol with maximal carbon conservation MCC HEL107 RPE PMC8354137__F1 Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay PINK1 CHCHD4 PARL PMC3807098__F1 Squalene Synthase Inhibitor Lapaquistat Acetate: Could Anything Be Better Than Statins? ARHA RAC1 CDC42 PMC4166715__F4 mTOR transcriptional activity RRAGD IGF1R SET BRAF PRKAA2 PTEN HIF1A MTOR PIK3R3 IRS1 PDPK1 RHEB TSC2 RICTOR TSC1 RRAGB RPS6 RRAGA EIF4B PMC2151969__F4 Genes up-regulated and down-regulated by FGF-2 in IGF-I signaling pathway ICE1 IGF1R IGF1 PAX2 ALK PMC2151969__F5 Genes up-regulated and down-regulated by FGF-2 in TGFB signaling pathway NR1i1 TLX2 NODAL FOS PITX2 SMAD2 HOXC8 GSC JUN FOXH1 PMC4905175__F1 Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis RIF1 ATM PMC7227208__F6 TGF-beta signaling pathway enriched in KEGG BAMBI E2F4 NODAL SMAD2 THSD4 FBN1 SMAD4 SKP1 ARHA TNF RBX1 IFNG FST THBS1 SP1 PMC5412951__F1 Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action GC GSK3B PMC9601711__F1 Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management FGF23 NR1i1 CYP2R1 CYP3A4 DBP HNRNPC WAS PMC2556276__F1 Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway HGF PLAUR NCL PLG HEL-S-28 EGFR HRAS SERPINE2 STAT1 PLAT VTN GRB2 SRC RAF1 JAK1 PMC8660968__F1 Regulatory Mechanism of 2-Acetyl-1-Pyrroline Biosynthesis in Fragrant Rice (Oryza sativa L.) Under Different Soil Moisture Contents DAO PRODH PMC12210776__F4 Key mechanism diagram of the combination of JZOL and AZ in the treatment of MPP MMP3 CXCL1 MMP14 PTGS2 CCL20 TNF SELE PMC8023395__F2 Towards personalized treatment for early stage HER2-positive breast cancer SRC PTEN MTOR PMC6141803__F2 Indoximod mechanisms of action IDO1 AHR KMO IDO2 PMC6321366__F3 Schematic overview of RAS and PI3K pathway and their interconnection TSC2 TSC1 PTEN RHEB PMC2774790__F6 Proteome Profile of Functional Mitochondria from Human Skeletal Muscle Using One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS CS HADHB ACADSB CPT2 DECR1 HSD17B10 HEL-S-32 MDH2 ACADS ACADVL PDHA1 ACO2 ACSL1 SUCLG1 SUCLA2 OGDH SUCLG2 ECHS1 ACSL3 DLAT SDHA ACADM PMC4715161__F2 Transforming growth factorB (TGFB)-activated kinase 1 (TAK1) activation by TGFB in mesangial cells SMAD2 ATF2 SMAD6 SMAD4 TRAF6 MAP3K7IP1 PMC3928987__F2 Cyclooxygenase pathway of AA COX1 PMC4023255__F5 TGFB family signaling for Müllerian duct regression ACVR1 AMH MMP2 BMPR1A AMHR2 SMAD1 DKFZp781O1323 PMC7692401__F1 Autophagy–lysosomal–endosomal system and the Parkinson’s disease (PD)-related proteins VPS35 LRRK2 FBXO7 VPS13C HEL-S-130P DNAJC6 PINK1 SYNJ1 PARK2 TMEM175 SMPD1 HEL-117 SCARB2 PMC4374766__F5 Macrophage Gene Expression Associated with Remodeling of the Prepartum Rat Cervix: Microarray and Pathway Analyses IFIT3 IKBKE CCR2 PGR PCDH7 ACHE MMP17 MATK DLX3 MRC1 BTK TLR7 CMTM3 CCR7 FOSB RHOB SLA NOSTRIN HCLS1 ITGB3 TP63 SAP25 PIGR FERMT3 TRIM29 HAS2 HEL-S-102 PTPRC SPTBN2 EGR4 PRKCB ITGB7 ARL11 MAP3K8 BDKRB2 FLT3 PLEK HVCN1 PMC2522268__F1 Interferon-inducible antiviral effectors IFNGR2 TYK2 IFNAR2 PMC6986718__F3 Impact of genotype, body weight and sex on the prenatal muscle transcriptome of Iberian pigs FRK GRB2 NR0B2 TRAF2 CRK PMC8602339__F1 Searching for DNA Damage: Insights From Single Molecule Analysis XPC ERCC1 POLL XPA POLI PMC3691611__F7 The proposed pathways that regulate astroglial CNTF CNTF LIF IL6 THY1 STAT3 PMC7530064__F9 Diagram of signaling pathway of IQGAP1 in regulation of VEGFR2-Src-Rac1 activation in choroidal angiogenesis IQGAP1 SRC RAC1 VAV2 PMC4505740__F1 Molecular targeting of the mitogen-activated protein kinase (MAPK), PI3K, and CDK4 pathways and the associated mutation rates of potential molecular targets in advanced melanoma () GNA11 NF1 KIT ERBB4 BAD FOS NRAS BCL2 CDK4 PTEN JUN AKT3 PMC9441553__F5 Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway MARCKS CALCA TREH C1QTNF2 PAFAH2 APP PSAP CP PMC5744685__F1 Targeting Metabolism for Cancer Therapy OMP DHFR DHODH PMC5744685__F8 Targeting Metabolism for Cancer Therapy MTAP MTR PMC3740364__F1 Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways TBK1 TRAF3 TRAF6 IRF3 TRIM25 MAVS PMC7277093__F12 Multiple modes of AOAA’s action on H2S producing pathways and other transaminases in cancer cells GOT2 GPT PMC10348770__F1 Treg-mediated immunosuppression and resolution of lung inflammation VAV1 RAC1 TNF PMC7140047__F2 Rac1 signaling pathways and their biological significance LIMK2 BAD LIMK1 PLK1 ARHA RHO PTEN RAC1 STAT3 NOXA1 PMC6318069__F1 Three tooth agenesis-associated signaling pathways EDARADD EDAR APC MSX1 TRAF6 GREM2 AXIN2 pp6425 TNLG7C Pax9 PMC6391768__F7 Schematic illustration of vitamin D/VDR’s regulation on HIF-1A as well as IFNG and IL-1B in oral keratinocytes TLR4 NR1i1 VHL IL1B IFNG PMC9597127__F3 Major STING combinatorial approaches with additive or synergistic effects CGAS APC STAT3 PMC9576928__F2 Advancement in understanding the role of ferroptosis in rheumatoid arthritis GPX4 LPCAT3 STEAP3 FACL4 SLC7A11 FTH1 ALOX15 FTL TFRC DKFZp686F0183 STAT1 SCD HEL-S-64p HEL-75 SLC3A2 ACSL3 PMC6795686__F8 The signaling pathways regulating TREM2 phagocytosis and TREM2 modulation of NFKB phosphorylation/activation SYK PMC3937046__F7 Neuronal circuit diagram of the light input pathway in the tadpole retina TH OTX2 PROX1 ISL1 PMC4756853__F4 Pathways involved in thymidine synthesis in Escherichia coli, Drosophila melanogaster and humans DCD DHFR DCTD DUT PMC6770402__F5 Apoptosis pathways (hsa04210) and targets of cordycepin TH BTD DOP1A PMC6719933__F4 Transcriptional regulation of GRINA and its role in cell survival GRINA NR1i1 ATF4 TMBIM6 PMC8107720__F5 Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer ATF4 GSK3B FGF19 FGFR4 STAT3 PMC7281533__F4 Reactive oxygen species (ROS) promote cellular inflammatory response and oxidative damage, which may impact cell and tissue viability in the lungs VIT KEAP1 BAX PMC9338059__F2 KOPI: Kinase inhibitOr Proteome Impact analysis FECH THRAP3 TANK STS NONO ACACA CTRL EGFR MYC MAP2K2 SGTA RHO PMC3969565__F1 Emergence and Evolutionary Analysis of the Human DDR Network: Implications in Comparative Genomics and Downstream Analyses KAT5 NHEJ1 HERC2 BABAM1 PLK1 FANCD2 MAPK3 UIMC1 PAXIP1 UBE2T USP11 SMC5 RBBP8 SOX4 TAOK1 XRCC5 TIMELESS WEE1 ATRIP MSH6 MDM2 ERCC5 MSH3 MSH2 POLI TDP1 HEL-S-71 MDC1 TOP3A XPC BARD1 RBX1 DDB1 MRE11A BRCA1 CUL4A CLSPN SLX1B ERCC1 XPA ATR SIRT1 DNA2 PCNA TERF2 BTRC HEL2 BLM UBR5 RMI2 CHEK2 RNF8 ATM KAT8 SMARCAL1 PRKDC SLX4 EME1 SKP1 SSB PARP1 RMI1 CHEK1 RAD18 PIAS1 PARP2 FANCM TRIM28 FANCL PMC24579__F6 Integration of tyrosine kinase signaling to both cAMP and MAPK 1,2 pathways, resulting in cell cycle arrest and the reduction of MAPK 1,2 triggered proliferation MAPK12 CCND1 MAPK1 PMC8025927__F1 Schematic model depicting the mechanisms of meiotic arrest KDM1A NPR2 CCNB2 APC CCNB1 TGFBR2 NPPC FSHR CDC2 GPR3 PMC3185772__F2 Regulation of Blood-brain barrier permeability, entry of WNV in the brain and factors involved in the pathogenesis of WNV-induced neuroinvasisve disease PLG CXCL2 CXCL12 TLR3 PMC7439920__F3 Critical role of HGMB1 in the complex interplay between apoptosis and autophagy HEL-S-102 HMGB1 ATG12 RHEB PMC2635670__F1 Apoptosis pathways: The extrinsic or death receptor pathway (left) is triggered by members of the death receptor superfamily such as Fas FADD BAX PMC6720817__F4 Intracellular signaling involved in cardioprotective response stimulated by ischemic postconditioning (PostC) in cardiac cells BAD GSK3B BAX PMC6720817__F3 Intracellular signaling involved in cardioprotective response stimulated by ischemic preconditioning (PreC) in cardiac cells BAD EGFR GSK3B SRC BAX PMC9312859__F7 FGFR2c/PKCE Axis Controls MCL-1-Mediated Invasion in Pancreatic Ductal Adenocarcinoma Cells: Perspectives for Innovative Target Therapies FGF2 MCL1 MTOR PMC2826677__F1 T-cell activation, proximal signalling complex and activation of transcription factors PLCG1 ITK BCL10 LCK ZAP70 GRB2 RAF1 LAT PMC9399644__F5 Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy SMAD2 EGFR SRC PMC6913740__F7 Carbohydrate metabolic pathway in ‘outer tissues', endosperm, and embryo of a barley grain and the differential transcript expression of involved genes in 18-6 transgenic grain from 7 to 24 DAP SPR DAP HEL113 PMC7279407__F2 Simplified diagram of the core element of the three unfolded protein response (UPR) signaling branches of the endoplasmic reticulum (ER) ATF4 EIF2A XBP1 PMC3701867__F1 Scheme depicting the interactive roles of interferon, Trim, and Socs molecules regulating the innate response in SjS-susceptible C57BL/6.NOD-Aec1Aec2 mice TLE3 SOCS3 TRAF6 TRIM8 IRF3 IL6 MTOR STAT1 OAS1 OAS2 TLR4 TRIM5 SOCS1 STAT3 MAL PMC4158832__F4 Planar cell polarity signaling in vertebrates PTK7 DVL1 PMC9663482__F9 Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3B/Beta-catenin/ZEB1 Signaling Pathway GSK3B PMC7755285__F11 Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat BAMBI LPCAT3 HSPA2 ALOX12 PLCG2 EPB41L4B MTOR EFNA3 BMP4 GNG4 GADD45B SSH3 FZD7 EPHA1 CTNNBIP1 SGK1 FZD10 F11R LIMK2 CLDN1 PPP2R1B CLDN4 LPIN3 ATP6V1B1 CDKN1A RPS6KA1 KLF4 SLC3A2 PLA2G2F SESN2 DUSP2 UNC5B EPHA2 PMC3871910__F7 Proposed synergistic mechanisms for induction of mitotic cell death in endometrial cancer cells with mutant p53 WEE1 MYT1 PMC11538000__F1 Pyroptosis regulation by Salmonella effectors NLRP3 RHO MLKL GSDMD DFNA5 PMC4071401__F11 Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis TWIST1 NRP1 VEGFA MAOA HIF1A PMC6851023__F2 Pathways leading to IDO enzyme production and regulation SOCS3 AHR TNF PMC11538000__F3 Salmonella plasmid virulence factors and pyroptosis NLRP3 NLRC4 GSDMD PMC4731283__F1 Evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies ZNRF3 RNF43 APC SOST CCND1 DKK1 BCL9 PMC11932863__F6 Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation CD6 SMAD2 WAPAL SMAD4 DBF4 CDK7 MTBP DDX11 MDM2 ESCO2 CDC2 NIPBL RAD21 TICRR MAU2 ESCO1 CDC14B SGOL1 APC STAG1 CDC45 STAG2 CDC20 SMC3 CDK2 CDT1 KNL1 PCNA SKP2 TRIP13 MYT1 PMC9205109__F8 Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury NLRP3 TXNIP GSDMD PMC5492985__F2 Canonical Notch Signaling Pathway: Structural And Biochemical Insights Into Shape, Sugar, And Force RBPJ KDM1B EZH2 KDM5A MLL2 PMC9395613__F1 Advances in cell death mechanisms involved in viral myocarditis NLRP3 MTOR FADD CP BAX PMC4505457__F10 Model for DAXX-mediated induction of tumorigenesis ULK1 PMC1559555__F1 GSH metabolic pathway GCLM NRF1 GSTM5 GCLC HEL-S-64p GSTM1 GPX1 HEL-S-75p HEL-75 PMC7573576__F4 Synthetic lethal pathway: multiple pathways NRF1 GFAP TRAF6 RHO GATA2 PMC7868569__F10 Chrysophanol-mediated suppression of the inflammatory response HMGB1 HDAC3 IL1B PMC7573576__F3 Synthetic lethal pathway: dual pathways PARP1 BRCA1 PMC7573576__F2 Synthetic lethal pathway: single pathway ARID1B ACTL6A SMARCA4 SMARCD1 SMARCC2 ARID1A SMARCC1 PMC7643807__F1B Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery SMAD2 GDF1 GDF10 GDF11 PS1TP5BP1 GDF3 PMC7015255__F6 Changes provoked by aerobic exercise training on microRNA‐1 downstream‐associated pathways in patients with chronic heart failure with reduced ejection fraction (HFrEF) PTEN MTOR MEF2C PMC2278039__F2 FIP200, a key signaling node to coordinately regulate various cellular processes TSC2 TSC1 CCND1 RB1 MTOR TRAF2 PMC7643807__F1A Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery SMAD2 SMAD4 GDF1 GDF10 GDF11 PS1TP5BP1 GDF3 PMC7378646__F2 Crosstalk between the Hippo-YAP1/TAZ pathway and Wnt signaling YAP1 APC LRP5 DVL2 LRP6 ARHA LATS1 LATS2 PMC7378646__F1 Overview of Hippo-YAP1/TAZ pathway and its role in cardiac biology YAP1 LATS1 LATS2 PMC7378646__F4 Crosstalk between the Hippo-YAP1/TAZ pathway and GPCR signaling YAP1 ARHA LATS1 LATS2 TRIO PMC7378646__F3 Crosstalk between the Hippo-YAP1/TAZ pathway and BMP signaling YAP1 SMAD4 LATS1 SMAD1 LATS2 DKFZp781O1323 PMC4207610__F7 HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst FGF4 SOX2 CDX2 GATA6 PMC4442456__F1 Changes in the expression of cell cycle-related genes during MNV-1 infection GSK3B SMAD4 SAXO6 GADD45A CDC25B EP300 WEE1 ATM CDK2 YWHAG TGFB1 PTTG1 TGFBI PMC6815541__F1 Probable mechanisms of the effects produced by lncRNAs on SCI TRIL TLR4 TCTN2 MAP2K4 KLF4 PMC4441984__F4 Scheme of the IL-11/STAT3/CDX2 pathway STAT1 SOCS3 CDX2 VEGFA BCL2 MTOR STAT3 PMC5889847__F3 CircRNAs function as ceRNAs in the regulation of apoptosis in tumor cells APAF1 FADD BAX PMC8495397__F3 Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling IL13 RELA TRAF6 LATS1 MYD88 LATS2 PMC8129516__F1 Glycogen Synthase Kinase 3B Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites STAT1 TLR5 WNT3 TLR4 TLR9 GSK3B MYD88 TNF FZD1 FZD5 DVL1 STAT3 PMC3635536__F5 Signaling Pathways in Schizophrenia: emerging targets and therapeutic strategies EGF DISC1 GRB2 NRG1 SOS1 MTOR PMC3140475__F5 Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients HEL-S-62p HRG C4B_2 HBD APOC3 HEL-S-92n C4A RBP7 SERPINA3 HPR SERPINC1 HP HBB SERPINA1 PMC4212952__F4 Network pathway analysis of differentially expressed genes in different subgroups of patients and controls HLA-DPB1 PITX2 LGALS12 STAT4 HLA-DMB HEL-S-43 PMC5992512__F2 Dynamic response of tumor cells to fluid shear stress BMPR1A CDC2 SMAD1 DKFZp781O1323 PMC7892237__F3 Autophagy: binding of growth factors to its receptor (tyrosine kinase) gets activated leads to the activation of PIP3K which phosphorylates PIP2 to PIP3 and recruits protein kinases PDK1 and AKT to inactivate TSC and RHEB TSC2 PML TSC1 TFEB BNIP3 MTOR PMC6059692__F4 Predicted regulatory networks affected by sinomenine treatment via Ingenuity®Pathway Analysis CST5 ABCF1 AASS FGFR2 MIA3 RICTOR AHR COL12A1 SSRP1 TGFB1 NUP155 DOCK9 RBL1 PMC7825621__F2 miRNA targeted network of cancer signaling including senescence CEBPE RBBP4 SMAD2 RTN4 CCND3 SUZ12 EED CCND2 AEBP2 CELF1 CDKN2B IL3 RBBP7 EZH2 KDM6B PCNA PMC11758815__F11 Cobalt signaling TRPM7 CBL PMC8222109__F1 Inflammatory Profile in a Canine Model of Hypothermic Circulatory Arrest MAPKAPK2 SOCS3 TRAF6 MAP2K3 RRAS2 HRAS MAP3K7IP1 PIK3C2G HEL-S-102 TNFRSF1B A2M NFKB2 CRP GRB2 JAK1 MCL1 TRAF2 SOCS1 STAT3 PMC3690356__F1 Calcium channels in T cells APC STIM1 PMC7924042__F7 Catalpol on AMPK pathway in alleviating DN NLRP3 GSDMD PMC7924042__F6 Molecular mechanism of catalpol in diabetic nephropathy EGR1 THBD DAO PDK2 INS PTEN FOXO1 CASP3 PIM1 TFEB IGF1 MMP2 VCAM1 BCL2 CDK4 SELE TF BAX PMC7924042__F9 Cardioprotective mechanism of catalpol in MI CASP3 ULK1 BAD ATG12 AMBRA1 CASP9 NRBF2 ATG101 ATG14 DKFZp686F0183 PMC8304138__F2 Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies CYP26A1 HEL111 PMC11796038__F8 CTSB induces ferroptosis via SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation GPX4 PMC7924042__F8 Cardioprotective mechanism of catalpol in diabetic cardiomyopathy CASP3 BAX PMC8945446__F2 Therapeutic Approaches Targeting Proteins in Tumor-Associated Macrophages and Their Applications in Cancers BTN3A3 PIGF SOX2 MMP9 TRIB3 PTEN CCL2 MTOR PDPK1 HEL-S-68p MMP7 TLR4 IGF1 MMP2 opn IL33 IL1RL1 CCL18 CDH2 GPNMB STAT3 PMC4138085__F2 Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury TBK1 GHB3 IKBKE MAPK9 GHB2 MAPK8 MAP2K4 IRAK1 MAPK14 TRAF6 IRAK4 TNFSF13 MYD88 MAP2K3 MAP2K6 TICAM1 IFNG MAPK1 JUN FOS MAPK10 MAP3K7 LTB IL12B NFKBIA LTA JAK3 TYK2 JAK1 TIRAP PMC9641982__F2 Innate immune mechanisms of mRNA vaccines STAT2 IRF7 IRF9 CXCL10 IRF3 MYD88 TNF TLR3 STAT1 TLR8 TLR7 GC JAK1 PMC3900522__F3 Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFBeta-Activated Kinase 1 Tyrosine Phosphorylation and NFKB Signaling in Multiple Myeloma and Bladder Cancer BAMBI UBC MGAT4A IKBKG SLC38A3 ACSL1 SCNN1G ZFAND5 PDXP SLC15A2 PSCA SGK1 PMC9442203__F8 Anti-proliferation and apoptosis-inducing effects of dihydroartemisinin on SH-SY5Y cells and metabolomic analysis HEL-S-62p C7 C6 PMC4414490__F1 Activation and Function of Small GTPases Rho, Rac, and Cdc42 During Gastrulation DAAM1 ARHA RAC1 CDC42 PMC8247097__F1 Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer IL10 NLRP3 HMGB1 BAD IL18 NLRC4 NLRP1 IL13 GZMA AIM2 IL1B BAX PMC3037835__F5 Major pathways of lipid metabolism in yeast FEN1 GHB3 PI3 PLB1 CDS1 PC GPT2 IDI1 PSD2 MIP GPD2 PMC7715033__F1 Immune and molecular mechanisms of FSGS pathogenesis CCR2 CLCF1 CD40 CD80 PMC3461905__F2 Molecular pathogenesis of mantle cell lymphoma BTK FYN BCR LYN GSK3B MDM2 NOTCH1 BCL2 SYK ADAM10 MTOR BAX PMC5992512__F3 Various factors activated by fluid shear stress (FSS) can induce tumor cells metastasis IGF2 MTOR VEGFB IL1B PMC5852671__F3 Significance of selenium in cancer stem cell metabolism TIGAR SCO2 ATM CITED2 PMC10968114__F6 TSG-6 Inhibits the NFKB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment RUNX2 CD44 DSPP PMC7970140__F2 Abnormal metabolic pathways CS MDH2 HEL-S-26 GOT2 PC FH PDHA1 ACO2 OGDH PCK2 SUCLG2 PFKP HEL-S-133P HK2 SDHA HEL-S-281 SDHB FASN ME2 HEL-S-30 PGM2 ENO1 DLD PFKL HEL-S-87p SLC16A3 HEL-S-162eP HEL-S-49 ASNS ACLY GLUD1 GLS PMC7663488__F3 Impaired regulation of lipid metabolism by AMPK in renal cells in obesity/diabetes HMGCR CD36 PMC7935450__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC8698071__F10 Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways GCLM KEAP1 GCLC SIRT1 NQO1 BAX PMC5757132__F7 Proposed mechanisms of miR-146a in alleviating experimental autoimmune anterior uveitis (EAAU) STAT1 STAT4 TRAF6 PMC10384750__F1 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer ULK1 ATG3 RHO MTOR SGK1 MLST8 PMC11588768__F2 TGP treatment: A TGP regulates the Wnt/Beta-catenin signaling pathway to treat IgAVN MAF GPX4 KLF4 APP TNF PMC10985998__F8 Expression of genes in carbon, ATP, NADPH metabolism in C OGDH HEL107 RPE HEL-S-162eP PMC10384750__F3 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer TSC2 TSC1 PTEN IRS1 RHEB PMC10384750__F2 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer RICTOR MTOR MLST8 PMC6785663__F1 Classic view on the pathogenesis of celiac disease IL15 APC ELL PMC10384750__F6 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer TSC2 TSC1 PTEN MTOR IRS1 RHEB PMC8264592__F2 Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence SRC MTOR BAX PMC7848718__F5 Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions PIK3CD CDKN2D TGFBR1 NOX4 CCND3 HMOX1 CEBPB NQO1 ATG9B KDR NR1B3 CCL14 VWF CDK4 JUNB ATP6V1A SELE ANGPT2 EGR1 PDGFRA FGF2 VEGFA PIK3R3 ID1 RXRA GPX3 DAPK2 VCAM1 NFKB1 KLF4 KLF2 CXCL12 TGFB1 PMC7916550__F5 Ingenuity Pathway Analysis downstream function prediction of the overlapping differentially expressed genes from the liver 3 h heat-control contrast and 4-week to 3 h control time contrast LOXL2 TGFBR2 NIP7 GINS1 MICOS13 CENPK SGCG CDKN2B RBP5 NMRK2 RRM2 H6PD PIKFYVE ZC3H12B SLIRP CPEB3 EPS15L1 TIMM10 MC5R COL10A1 PMC7848718__F4 Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions NOX3 GPX1 MAPK14 MAOA NOX4 HMOX1 NQO1 GSTT2 HEL-S-44 XDH CYP1A1 JUNB SP1 UGT1A3 TXNRD2 FOS GCLC MAPK10 NFE2L2 CYBB GPX3 MGST1 TXN2 NFKB1 HEL-75 TF PMC6544834__F1 Progress in the Management of Malignant Pleural Mesothelioma in 2017 NF2 MDM2 PTEN EZH2 BAP1 PMC9350707__F4 Immunomodulatory role of T helper cells in rheumatoid arthritis TNF IL1B PMC10492386__F10 EVs interacting with immune cells NLRP3 TLR4 MYD88 PMC7139827__F1 Endoplasmic reticulum (ER) signaling pathway and the ER–mitochondria pathway triggered by natural compounds ATF4 EIF2A TRAF2 PMC4358941__F2 Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity CIT HEL-S-133P MDH2 MAL PMC6563521__F5 Upregulated genes in proteasome biosynthetic pathway at 24 h after inoculation using F RET RPA3 RPA1 POMP ARC RPE RPN1 IFNG PMC7429955__F7 LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression MDM2 GATA2 PMC5966875__F1 Synthesis and metabolism of common bile acids in human CYP27A1 CDA HSD3B7 PMC6523616__F8 A transcriptional and post-transcriptional regulatory system mediating the hepatic metabolic switch in chickens FOXO3A GPT2 HDAC2 HEL-S-31 MSMO1 FASN PMC11617665__F1 Metabolic signaling pathways modulated by PTP1B PTEN IRS1 STAT3 PMC8171523__F1 Wnt信号通路对软骨和软骨下骨双靶向调控及其在骨关节炎进展中的作用 APC RHO PMC4424075__F3 Innate Immune Evasion by Filoviruses STAT2 TYK2 IFNAR2 JAK1 IFNAR1 PMC4424075__F2 Innate Immune Evasion by Filoviruses TBK1 TANK TRAF3 MAVS PMC7029263__F2 TRPV1-CNTF signaling cascade in PD CNTF TRPV1 STAT3 PMC7029263__F1 Wnt/Beta-catenin signaling cascade in Parkinson's disease LEF1 APC GSK3B LRP5 LRP6 PMC3725164__F1 TGFB signaling pathway SMAD2 SKI PMC10218870__F1 Schematic diagram showing the main molecular targets of luteolin during the initial steps of the metastatic cascade MDM2 NOTCH1 SRC CDH2 MTOR STAT3 BAX PMC8899398__F3 Lactoferrin: A Nutraceutical with Activity against Colorectal Cancer APAF1 BAX PMC11036006__F13 Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation PI3 BAX PMC11273248__F1 Flavonoid compounds exerting protective effects against brain injury after ICH CASP3 NLRP3 TRAF6 NQO1 BAX PMC8168427__F7 Proposed mechanisms of ALDH2*2 to induce atrial fibrillation HEL-S-53e ALDH1A2 ALDH2 PMC4752785__F3 Scheme of the molecular mechanisms that systematic exposure to cigarette smoke can influence during carcinogenesis of the mammary gland EGFR SRC BCL2 PMC4752785__F2 Scheme of the molecular mechanisms that ethanol consumption can influence during carcinogenesis of the mammary gland F2 AREG EGFR AMPH TGFA PMC11273248__F2 Flavonoid compounds exerting protective effects on SAH CASP3 NLRP3 KLF2 SIRT1 NQO1 BAX PMC8671582__F2 Pathway network analysis of the significantly differentially expressed lncRNAs and mRNAs NAIP SDHC NLRC4 OPLAH MAPK14 RNASEH2B CARD6 SLC22A4 CAB39 TNF MTOR MAP2K6 FLOT2 ALPL PDGFC F5 PYGL PMC6581439__F6 Shown are the edges whose scores exceeded the threshold ; edges are labelled with their scores PRR9 ELF3 PRR5 ELF4 PRR3 PMC5328618__F8 Model for how APC mutations affect insulin-induced dynein movement toward MT minus ends APC GSK3B INS NDEL1 PMC5027283__F5 Oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway HEL-S-26 DEPTOR KDM4A PMC4439562__F4 GPCR (or GPR) signaling in the regulation of Beta-cell proliferation PDX1 BTC GIPR CDK2 EGFR TCF7L2 GIP SIRT1 CCND2 FOXA2 PMC3481051__F3 The different main molecular pathways that are involved in neuronal stress response VHL TF XPO5 PMC4439562__F3 Cadherin and integrin signaling pathways APC GSK3B TCF7L2 PMC4439562__F1 Cytokine and hormone signaling through JAK-STAT pathways TPH1 FOXM1 PRLR GRB2 SH2B1 PRL BCL6 PMC9687146__F5 Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism SOX2 ATM CDK2 CD44 ATR PMC5137220__F1 Summary of genetic and pharmacological evidence implicating Wnt signaling in developmental cognitive disorders APC LRP5 LRP6 PTEN MTOR PMC12078813__F8 TD formation EGF PMC3753830__F1 Schematic overview of signalling pathways and drug targets currently under investigation in CML research PML ALOX5 SMO MTOR PMC6174864__F8 A working model illustrating HHcy-induced ER oxidative stress and inflammation in endothelial cells VCAM1 ERO1A GPX7 PMC6388721__F3 Simplified illustration of TXNIP role in presumptive pathways involved in endothelial dysfunction NLRP3 VCAM1 SRC TXNIP KLF2 PMC3078022__F1 Tumor heterogeneity and strategies to overcome kinase inhibitor resistance in cancer: Lessons from melanoma BRAF ARAF PMC4297928__F1 Simplified pathophysiology of reactive oxygen species (ROS) and etheno-DNA adduct formation COX2 MPO PMC8041338__F1 Imipridones in targeting mitochondrial metabolism in cancer cells ATF4 CLPX BCL2 CLPP BAX PMC5451507__F2 Congenital heart defect BioCore (CHD-BioCore): strategy and frame work GSKIP IMPACT EGFR SRC PTEN PMC5532733__F2 Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation EGR1 GGPS1 HMGCR PMC2174972__F7 The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic Activity TRADD LTB TRAF6 PMC8630009__F6 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology MAX TRADD FOS HEL-S-11 LIF TNF FADD SELE PMC2824905__F2 IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus SRP54 COPZ1 ESAM PSMB3 PCSK5 ATP8 AQR THRSP CEACAM7 RBM34 PRPF31 SLC35A1 SART1 NDUFB8 EIF3B B4GALT2 SLU7 RPS20 RAVER1 ATP6V0B PRCC PIGT NDUFB9 ATP6V0C PRSS8 RPS16 YTHDC1 RAB10 COPB2 SNRPD2 KRTCAP2 B3GALT2 EIF3S3 PHYHIP BACE1 IFITM3 ADAT1 NUTF2 RAB30 DMD CWC22 TGS1 CADM2 RPS5 COPS8 PIGH NUP107 PRPF8 RPS15A CNTN5 NDUFB11 RPS14 RPL13a SAMM50 SNRPD3 FHOD3 GSK3A PFKL PPAN PCDHGA1 NR1C1 FUS SCYL3 CALCOCO2 EIF3F NDUFB1 SNRPB STAC3 MPZL1 NUP98 EIF2AK4 CRADD LSM2 MOCS3 SIGLEC9 PLCH2 PMC8630009__F8 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology DAO HP PMC7285601__F1 Simplified schematic of pyrimidine nucleotide synthesis showing enzymes targeted for cancer therapy CDA DPYD DCTD UMPS SLC29A1 CAD DHODH SLC28A3 SLC29A3 CTPS2 PMC4155023__F3 Growth factor- and cytokine-regulated pathways are activated during liver regeneration HEL-S-62p SOCS3 PLG UNK CCND1 STAT3 PMC6381212__F8 Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma MTOR BAX PMC3356053__F10 Most significant canonical pathway from this study OCEL1 MAX MYC GRB2 CRK PMC7878670__F2 IGF-1R trafficking routes and signaling to the mitochondria and from the Golgi and the Nucleus LEF1 IGF1R IGF1 GSK3B SNAI2 CCND1 BNIP3 AXIN2 RANBP2 JUN IRS1 PMC7415793__F4 Treg in cardiomyocyte regeneration TNFSF11 CCL24 AREG IGF2 FGL2 CST7 PMC8836222__F10 Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains GGH FPGS DHPS PMC3057147__F1 Top associated network functions for miR-141 and miR-200c DIPLA1 DKFZp761E1322 PMC8541208__F5 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis TRADD MCL1 TNF TRAF2 FADD BAX PMC8541208__F4 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis ZER1 ELOC RBX1 PMC5009010__F9 Schematic signal transduction network representing the effect of chronic alcohol on protein balance in eWAT TSC2 EEF2K ULK1 TSC1 ATG12 EEF2 EIF4E EIF4B DKFZp686F0183 RHEB PMC6585021__F4 The molecular mechanism of OM antifibrogenic effects.OM could attenuate HSCs activation induced by TGFB1 in vitro by down-regulating the expression of miR-195 and up-regulating Smad7 SMAD2 SMAD4 PMC8850260__F8 Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NFKB/HPSE1 Signaling Pathway During Inflammation TLR4 SDC1 VCAM1 PMC6515079__F10 Network analysis of proteome datasets in M2 polarized (vs EIF4A1 HES6 HOOK1 NONO NACA HEL-S-87p RPSA CD59 CNR2 KHSRP HNRNPC MSH3 YWHAG HEL-S-72p KRT10 PMC5972417__F7 The FA pathway and SPR-5 cooperate in DNA repair and regulation of histone demethylation FAN1 FANCD2 FANCM PMC5355638__F2 Mechanisms of RSV T-cell interference as a potential immune evasion strategy MTOR PMC7976584__F6 MiR-362-driven TGFB/SMAD signaling modulation of cell migration and invasion: a proposed scheme SNAI1 SMAD2 SMAD4 DACH1 PMC2469272__F2 LPS signaling [modified from O’Neill and Bowie () with permission] CD14 TLR4 IRF7 TRAF3 TRAF6 IRF3 MYD88 MAL PMC7737291__F1 Genes found altered in Central Carbon Metabolism (CCM) pathway in gingivo-buccal oral cancer PIR PTH CIT GLA PMC4941333__F9 Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3B/Beta-catenin pathway AQP3 GSK3B CD44 PMC6055056__F4 FoxO signaling pathway GHB2 ATG12 INS GOPC PTEN NLK ATM CDK2 MDM2 IL7R KLF2 BNIP3 SKP2 STAT3 PMC6055056__F5 Signaling pathways involved in susceptibility to Salmonella enteritidis infection PIK3CD IL13RA1 EGFR HOMER3 BMP7 TNFRSF11A IRS1 IL10RB INSR BCL6 IKBKB TNFRSF25 CREBBP IL18 PIAS2 NGFR SETD7 PDGFA CXCR4 CCND1 IL10RA SOCS1 PMC7110972__F7 Proposed rES/ID1/TSP-1 signaling pathway CD47 ID1 CD36 PMC3889250__F1 The BDNF signaling network NFATC4 NGF EEF2 APC NTRK3 MTOR SHC3 ADAM17 ALPL NFKBIA SIRPA RELA SRC PTPRE SHC4 JUN NCF2 PMC8257821__F6 PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling MAF1 PTEN FASN PMC4172469__F7 Estrogen Regulation of microRNAs, Target Genes, and microRNA Expression Associated with Vitellogenesis in the Zebrafish E2F4 SMAD2 GSK3B SMAD4 STAG1 CDK7 CDC45 STAG2 CDK6 PI3 CDK2 MDM2 CDK4 PCNA SKP2 MYT1 PMC7599606__F2 An integrative view of glutamine metabolism HEL-S-26 FASN MAL GLS PMC8728518__F2 PLK1 inhibition-based combination therapies for cancer management PLK1 EGFR SRC MTOR CRBN STAT3 BRD4 PMC4393358__F3 FGF signaling pathways TSC2 GRB14 GRB2 ETV4 SHB ETV5 FOXO1 CRKL CBL PMC3759480__F3 Wnt/Beta-catenin signaling was activated in gemcitabine resistant NSCLC cell lines MYC MDM2 CD44 DKK1 JUN TCF4 PMC5336655__F4 Example of a visualisation of a significant pathway using the SetRank package RARA CD14 PML KIT MPO CD33 RUNX1 SPI1 NRAS CEBPA WT1 CBFB PMC4393358__F1 FGF and FGFR families IL1B TK1 PMC5593677__F2 Promising landscape for regulating macrophage polarization: epigenetic viewpoint EBP IRAK1 SMAD2 IRAK2 TRAF6 HDAC1 STAT1 PKNOX1 KLF13 JAK1 CXCL12 KLF6 INHBA PMC9671555__F4 Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease SLC6A19 ACE2 PMC9441790__F3 Primary cilium in kidney development, function and disease INVS APC GSK3B PMC6050292__F7 Dynamics of S1P- and ceramide-synthesis pathway PLPP2 PLPP1 SGPP1 SMPD2 MAPK3 ORMDL1 GBA2 SPHK2 opn CERS3 ACER3 MAPK1 LASS1 CERS5 ABCG2 CERK CERS2 PLPP3 IL6 SPNS2 ASAH2 SMPD4 ORMDL2 ORMDL3 UGCG ACER1 ABCC1 SGPL1 SPHK1 DEGS1 SGMS2 DEGS2 CERS6 STAT3 SGPP2 PMC9441790__F2 Primary cilium in kidney development, function and disease WNT4 WNT9B FGF8 PAX8 PMC7468582__F9 WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation HEL-S-52 STAT3 PMC8305593__F1 An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells TH LCK STAT4 WDR5 MDM2 BCL2 IL4 IFNG PMC8992454__F1 Barriers to achieving a cure in lymphoma PIK3CD PLCG1 TRAF3 TRAF6 BCL2L1 PTEN MYD88 MTOR PDPK1 BTK NFKBID BCL10 BCR PIK3AP1 INPP5D JUN CD19 SLA FOS VAV1 CD79A IKBKB NFKBIA CARD11 PRKCB LCK LYN ZAP70 GRB2 DGKZ PIK3CA BCL2 SYK MCL1 SOS1 TNFAIP3 ZC3H12A TRAF2 NFKBIE PMC10971254__F10 Binding of IL-33 to its receptor induces the MyD88/IRAK1/IRAK4/TRAF6/NFKB- dependent signaling pathway and the TRAF6/MAPK/AP-1-dependent signaling pathway IL33 TRAF6 MYD88 PMC2909379__F3 Hox Genes and Regional Patterning of the Vertebrate Body Plan CDX2 HOXC13 PMC9578855__F7 Eucommia ulmoides Oliver's Multitarget Mechanism for Treatment of Ankylosing Spondylitis: A Study Based on Network Pharmacology and Molecular Docking tal-1 PMC10498433__F8 Lactate-induced oxidative stress MMP3 NOX4 HK2 HCAR1 CCL3 PMC10960062__F7 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity PBRM1 CS CREB1 GPS2 HSF1 ONECUT1 CEBPB HEL-S-32 MDH2 DHTKD1 TBP FOXA1 ACO2 TAF3 PCK2 SUCLG2 RAD21 SDHA NR3C1 CEBPA HEL60 CREBBP HNF4A EP300 GABPA RORA ACLY PPARG NR1D1 TF BRD4 PMC10960062__F6 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity GPT NELFA GCK GPS2 PROX1 XBP1 TBP FOXA1 GPT2 PKLR AGXT TAF3 HEL-S-133P NCOR2 ALDOB HEL-S-30 FBP1 PFKL HEL-S-87p STAG2 RXRA HEL-S-68p HEL-S-49 CREBBP EP300 RORA PPARG NR1D1 AGXT2 TF BRD4 PMC10960062__F5 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity NR3C1 NELFA CEBPA GPS2 XBP1 ONECUT1 CEBPB RXRA CREBBP HNF4A EP300 FOXA1 PPARG NR1D1 RAD21 TF BRD4 PMC4362638__F4 IPA-inferred Sertoli cell – Sertoli cell junction signalling pathway A2M SYMPK ATF2 MTMR2 CGN PALS2 CDC42 PMC7001271__F1 GPI biosynthesis pathway PIGU PIGF PGAP1 PIGT PIGO PGAP2 PGAP3 PIGW PIGY PIGX PIGS PIGV PIGK PIGN DPM2 MPPE1 GPAA1 PIGC PIGH PIGM PIGA PIGP PIGL PMC10527779__F3 Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View PINK1 PICALM PMC6073722__F3 APC activity is decreased under nutrient conditions, and increased when nutrients are limiting SIRT2 CDC23 APC CDC27 ELP3 HEL-S-92n CDC34 SKP2 PMC8969394__F1 Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency MVD MVK IPP MVP PMC8619966__F1 Hedgehog Pathway Inhibitors against Tumor Microenvironment IL10 IL18 SUFU IL13 SMO CCL28 IL6 IL4 PMC4588730__F2 Functions of FGF19 and the corresponding mechanisms FGFR1 FGF19 FGFR4 PMC3408431__F8 RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System HEL-S-62p ARHA RHO PMC6111862__F6 Model of ADAM‐17/EGFR signalling axis activation induced by deoxycholic acid in intestinal carcinogenesis AREG EGFR ADAM17 PMC4053266__F3 Integrative pathway analysis ARHH ICAM3 VCAM1 CXCR4 DCT TEC BCL2 ARHA SOX10 PECAM1 PAX3 PMC5473031__F6 Gestational exposure to sidestream (secondhand) cigarette smoke promotes transgenerational epigenetic transmission of exacerbated allergic asthma and bronchopulmonary dysplasia RUNX3 BCL2 PMC4309199__F2 Toll-like receptors and IL-1 receptor family signaling pathways TLR5 TLR7 TLR4 MYD88 TLR3 PMC2576557__F10 Schematic diagram showing the pathway involved in high glucose- and high insulin-induced extracellular matrix protein synthesis mediated by GSK3B and eIF2BE EEF2 GSK3B EIF4E MTOR PMC11355432__F7 Proposed model for the protective mechanism of CPE against CKD-induced HAS PC DBP ACE2 PMC5615778__F2 Working model for sensing of glucose availability by AMPK and its potential interactions with the mTORC1 signalling pathway at the lysosome TSC2 TSC1 RHEB PMC8276045__F2 T Cell Specificity: A Great Challenge in Chagas Disease TH HLA-A CD2 APC CD40 PMC3807489__F8 Proposed metabolic models for syntrophic growth of D POR HEL-S-133P PMC2671566__F7 Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor MUSK LRP4 LAT PMC3044050__F6 Spry2 and Spry2Y55F function in the context of EC MAPK signaling GRB2 RAF1 SOS1 SPRY2 PMC4100437__F1 Hypothetical model of chemoresistance in human ovarian cancer cells MDM2 CDK4 CDK6 BAX PMC6103457__F1 Cilia and intraflagellar transport IFT140 IFT27 IFT172 IFT80 IFT52 IFT22 TTC26 IFT43 IFT46 IFT74 IFT57 IFT25 IFT81 IFT20 PMC7869012__F6 Bioinformatics analysis of sevoflurane altered lncRNA-related pathways based on the dysregulated lncRNA co-expressed dysregulated mRNAs using ingenuity pathway analysis (IPA) software PIK3R1 ALDOB ST8SIA4 NR3A2 GFAP S1PR4 TNFRSF11B SFRS5 KBTBD2 LEP DUSP5 EGR4 NR4A3 SLC40A1 JUN PIANP SRXN1 SCN11A PMC8416371__F10 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis FRY INA KY PMC3820656__F1 Scheme of the endothelial angiopoietin (Angpt)/Tie2 system highlighting fundamental signalling pathways ANGPT2 ANGPT1 RHO RAC1 PMC7690450__F2 Curcumin, as a multitarget compound, induces apoptosis and cell cycle arrest in neuroblastoma (NB) cells through the modulation of PTEN–Akt, NFKB, and p53 signaling; mitochondrial dysfunction; and caspase activation BAD FOXO3A PTEN PMC5693401__F3 Signaling pathway network model: Panel (a) presents the biological network describing the mTOR pathway (based on Fig EGFR PTEN EIF4E MTOR PMC7412400__F7 Mechanistic map depicting the potential role of the HDAC1/LSD1/SESN2 pathway in VC in CRF HDAC11 SESN2 MTOR PMC8608878__F6 Schematic presentation of the circKDM4C-regulated pathway in BCa cells KDM4C CDH2 PMC8576090__F3 Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19 MYD88 ACE2 PMC5117516__F1 Viral sensing pathways that trigger host immune responses TBK1 STAT2 IRF7 IRAK1 IRF9 TRAF3 TRAF6 IRF3 IL6 MYD88 NOD2 STAT1 NLRP3 IL18 TYK2 JAK1 MAVS PMC3157296__F8 Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth EGR1 FKBP5 PTEN EZH2 MTOR JUN PMC10648981__F3 Jasmonates in coordinating secondary with primary metabolism HEL-S-70p IPP PMC11674460__F2 The molecular mechanism underlying the pleiotropic anticancer activity of As2O3 against GBM cells ATM NOTCH1 XPC ATR XBP1 BAX PMC6348685__F4 Putative genes and their expression patterns in the biosynthetic pathway of astaxanthin in H DHDDS FDPS PMC11674460__F6 The molecular mechanism underlying the pleiotropic anticancer activity of tetrandrine against GBM cells and GSCs EGFR CCND1 PCNA BAX PMC6062504__F6 DLX1/DLX2 may influence MAPT via WNT or GABA signaling pathway DLX2 GABRB3 GABRA5 WNT1 WNT10A CUX2 LHX8 SLIT1 DLX1 PMC7175771__F1 Autophagy pathway ULK1 ATG16L1 ATG12 ATG3 ATG101 ATG10 MTOR DEPTOR DKFZp686F0183 PMC3169508__F3 Pathway interactions and detailed network visualization for the interactions with three apoptosis related pathways for the comparison between HF and LF diet at t = 0 MAPKAPK2 MAP3K1 CHUK PRKCZ MAPRE1 TUBB IRAK1 CEP57 PRKAR1A PLK4 GSK3B MAPK14 NRAS JUP CTRB1 SOS1 PRKCH PMC7737552__F1 Huaier induces apoptosis by upregulating p53 expression GSK3B PTEN MTDH EZH2 MTOR PMC11987792__F3 Exosome-mediated DOX resistance in BC PIK3R1 RNF11 NOTCH1 PTEN PMC3169508__F2 An indirect interaction between the Axon Guidance and Insulin Signaling pathways in the network for the comparison between HF and LF diet at t = 0 TSC2 TSC1 GSK3B FES FOXO1 CDC42 PMC8545927__F2 Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information PSG1 HLA-G REN INS PSMD9 PTPRN2 DES CASP2 STK24 AGTR2 FOXP3 IFNG CMAS TAGAP BTC SOX13 MICA BMX GNAL FABP2 GCKR IRS4 G6PC2 IRGM AIRE ENG IL6 LTBP1 PTPN22 CTSG RFC1 PTPRN HLA-DQB2 SLK LNPEP PXN PMC8759629__F1 MICROGLIA AS THERAPEUTIC TARGETS AFTER NEUROLOGICAL INJURY: Strategy for Cell Therapy IL13 TNF PMC9046545__F10 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review BTK FGFR1 FGFR3 FGFR2 PMC11987792__F5 Exosome-mediated platinum drug resistance in breast cancer NLRP3 PIMREG PGP BRCC3 PTEN PMC6589740__F1 Diagram of the proteins and precursor/product sugars involved with guanosine diphosphate-fucose synthesis, Golgi transport and attachment of core fucose to N-linked glycoproteins FUT8 GMDS SLC35C1 FPGT PMC7737552__F2 Huaier inhibits cell proliferation and metastasis by upregulating DARC and downregulating its ligands YAP1 BMI1 CDH2 PMC7895513__F7 Regulatory effects of PCSK9 on endothelial cell pyroptosis by increasing ROS production via the inhibition of UQCRC1 NLRP3 PCSK9 UQCRC1 IL1B GSDMD PMC4669196__F3 Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms CGAS TLR9 DHX36 DDX41 IRF3 MYD88 AIM2 IL1B MAVS IFI16 PMC9585259__F2 Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccination HEL-S-62p EGF APOA4 CLEC3B ARHA GAS1 KIN HEL-S-87p ITIH4 CLU UBC ITGAM GPC1 CFD ORM2 HEL-S-2 AHSG VWF ACTN4 GNB1 APOE CDC42 PMC9403860__F1 How the crosstalk between innate immune sensors and metabolic pathways affect the outcome of Brucella abortus infection? MYD88 HIF1A MTOR AIM2 IL1B PMC5175149__F7 Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide TYK2 IFNAR2 JAK1 IFNAR1 STAT3 PMC11242587__F1 Association of type 2 diabetes mellitus with cancer, for example, pancreatic cancer IGF1 MTOR INSR STAT3 PMC10507626__F2 Molecular mechanism of inducing cognitive impairment in OSA patients through intermittent hypoxia (IH) BACE1 NLRP3 MYD88 PMC5268776__F12 Differential Feedback Regulation of Δ4-3-Oxosteroid 5Beta-Reductase Expression by Bile Acids CYP8B1 SI AKR1D1 CYP7A1 PMC12100627__F9 Mechanism by which rSPD promotes in vitro replication of IBRV RSAD2 TLR9 STAT2 IRAK1 IRF9 IRAK2 TRAF6 MYD88 MX1 STAT1 ISG15 OAS2 TLR4 S100A8 TYK2 IL1B IFIT1 CCL3 PMC9496435__F3 Targeted genes in the mitogen‐activated protein kinase pathway (MAPK) EVI1 SHF ACD TF PMC7320879__F1 Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease RORC TLR4 FOXP3 PMC3173146__F8 Summary and working model SP110 EGFR SRC PMC7222183__F1 Main mechanisms in ferroptosis GPX4 LPCAT3 FACL4 HEL-S-64p ALOX15 ADA HEL-75 PMC8597024__F6 Identification of miR-499a-5p as a Potential Novel Biomarker for Risk Stratification in Endometrial Cancer APC GSK3B PMC4404917__F1 Synthesis of EPA, DPA and DHA from ALA FADS2 ELOVL1 FADS1 ELOVL2 HSD17B4 ACOX1 HEL-S-5 PMC12000086__F5 Synthesis pathways of 16 esters and alcohols PDC HTT ACD PMC7222183__F3 Charcot-Marie-Tooth disease (CMT) pathways related to oxidative stress MFN2 HSPB8 PMC5915042__F1 Scheme describing the mechanism of lethal autophagy induced by DDA TFEB EBP NR1H2 PMC5808733__F1G Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission STAT1 STAT2 IRF9 TYK2 IFNAR2 JAK1 IFNAR1 PMC3340193__F8 Scheme to explain the increased production of HA in fro/fro (NSMase2−/−) mouse fibroblasts PTEN MTOR HAS2 PMC5640978__F4 Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection CCL4 CCL2 TNF CCL3 PMC7311766__F2 DAMP/PAMP PPR pathway manipulation NLRP3 GSK3B SYK MYD88 GIT2 IRF-1 MAL PMC6858840__F1 NAD+ biosynthetic and degradative enzymes NAPRT NAMPT HEL-S-90n SARM1 NRK PMC2922498__F2 Schematic for DSB repair by HR and NHEJ pathways PALB2 RAD51 POLN BRCA1 RAD51C PMC7592369__F4 Role of HIFA on fatty acids metabolism during cancer progression via epigenetic regulation CS PTEN PMC7592369__F1 Canonical and non-canonical regulation of HIF signaling EPO GRB2 CCND1 PTEN MTOR PMC6282138__F6 Proposed mechanisms of lipoprotein uptake and Fluocinolone acetonide effects on inflammation and lipid accumulation in THP-1 derived foam cells GCGR GC CD36 PMC10985004__F5 Construction of signaling pathway between DEPs HMGB1 SMCP GPX4 ALOX12 CREB1 ACADSB MTOR LMNA FABP9 ACAT2 TRPM8 HEL-S-102 STAT1 RAB21 CCDC39 RSPH9 ASNS CREM CYC1 DNALI1 PPARG TGFB1 PMC8472822__F1 Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases GPX4 LPCAT3 STEAP3 FACL4 ADA IPP CP PMC8055737__F1 ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke: Highlights of the Phase 3 Clinical Trial on Nerinetide PLG PMC10379230__F5 Isoflurane Anesthesia’s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model SULT1A1 LRRC58 EGR2 BCL6B APOLD1 GPR22 SOST ZBTB41 RANBP2 WFS1 PMC9072078__F7 Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells TRAF6 MYD88 CSA2 PMC5654406__F1 Sequence Evidence for the Presence of Two Tetrapyrrole Pathways in Euglena gracilis FECH UROD UROS CPOX PMC2519541__F2 Integration of the AinS-AinR and LuxI-LuxR quorum sensory pathways C6 MED8 PMC4362662__F7 A hypothetical illustration for the mechanism of resveratrol on the EMT of colorectal cancer SMAD2 PMC10728906__F4 Inflammatory activation of astrocytes and microglia by Alpha-Syn and phenotypic switching between astrocytes and microglia NLRP3 CX3CL1 CCL5 MYD88 TNF MTOR PMC6803543__F3 Ras signaling pathway shown as an interacting network ATF2 RASA2 CREB1 PTEN RHO SHC3 RASA3 CRKL CDK6 FYN BCR ATF4 GDNF CDK4 GNAL RAB5A RIN1 CREB3 SHC2 RET LCK ZAP70 GRB2 SYK SHC1 LAT CDC42 PMC4530548__F1 Antiviral Defense Mechanisms in Honey Bees AGO2 UNC80 REL FADD PMC7460696__F1 Lysophosphatidate (LPA) signaling pathway RHO LPA PMC9614042__F10 LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing TLR4 IRAK4 MYD88 SF3A1 PMC6961113__F1 B-vitamins, one carbon metabolism and related pathways CTH MTR SHMT1 MTRR CBL PMC3905285__F4 Possible pathways for lipoic acid attachment to mitochondrial Alpha-ketodehydrogenase apoenzymes LIPT2 LIPT1 LIAS NFU1 BOLA3 PMC5968387__F8 Signaling pathways that are postulated to upregulate the expression of A20 and then inhibit inflammatory mediators in macrophages induced by M protein following GAS infection IL16 TRAF6 MYD88 IL1B PMC6185797__F1 GSK-3 regulated signaling pathways and splicing factor phosphorylation APC LRP5 LRP6 PMC6803282__F3 Mechanistic network analysis predicted by Ingenuity Pathway Analysis HEL-S-99n CXCL8 CREB1 HIF1A XBP1 FGFR2 HEL-S-2a DCN PLAT opn CSF2 ANGPT2 HEL-S-89n CFB MMP9 TCF7L2 TNF PTHLH HEL-S-162eP HEL-S-125m UBE2C MMP14 HMMR SDC4 TNFSF10 C6 CXCL12 INHBA PMC9524788__F1 CGAS-STING Pathway - Implications for Systemic Lupus Erythematosus TBK1 CGAS IRF3 CDC2 SLC19A1 PMC11760447__F1 Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application CS ACAT1 OXCT1 HMGCL PMC11847347__F6 Cancer-secreted exosomal miR-1825 induces angiogenesis to promote colorectal cancer metastasis ING1 SMAD2 PMC12060536__F10 Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury DCD CDKN1A GDF15 NPS LONP1 MMP9 ATF5 CDKN2A SIRT1 CLPP PMC7692384__F10 Neurofibromin regulation of the growth factor-controlled Ras/PI3K signaling pathway NF1 TSC2 GRB2 MTOR RHEB PMC6021760__F5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer ULK1 NUAK1 PLK1 CSK MTOR AURKA PRKD1 PDPK1 ATM LYN NEK2 CDK4 ATR PMC3431075__F1 NFKB members and NFKB signaling BCR RELA RELB CD40 PMC8934560__F3 Nourishing Better Vision: The ARVO 2021 Mildred Weisenfeld Award Lecture ELOVL1 ELOVL4 ELOVL5 ELOVL3 DES ELOVL2 PMC5187800__F8 Schematic representation of metformin roles in TGFB1-induced epithelial-to-mesenchymal transition in cervical carcinoma cells MTOR STAT3 PMC3705591__F2 Common signaling pathway for Toll/IL-1R (TIR) family members IRAK2 IL33 TRAF6 MYD88 PMC8880046__F2 Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection CD69 STAT3 PMC9379395__F8 Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway EGR1 PMC9157490__F3 Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha TLR4 HEL-S-69p PMC8436617__F3 N6-Methyladenosine in Cancer Immunotherapy: An Undervalued Therapeutic Target METTL14 METTL3 CD40 CD80 TIRAP STAT3 PMC8950598__F1 Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD TRADD TRAF1 RIPK3 REL COMP TRAF2 FADD MLKL TAB3 PMC4013670__F6 Schematic describing the proposed anti-inflammatory response resulting from resveratrol treatment and its effects on TLR4 following stimulation of chondrocytes with IL-1B TLR4 TRAF6 MYD88 IL1B PMC4480196__F1 MTOR-mediated T cell activation and lineage specification TSC2 TSC1 RHEB FOXP3 HEL-S-162eP PMC6311899__F3 Result of newborn mouse lens epithelial cell MYB E2F8 FZD3 EFNB2 ETV4 FGFR2 CACNA1C PLXNB1 FGFR1 FZD2 SRC ZHX2 CDH2 PTPRM NOTCH2 GPC5 RFX3 ADCY1 LRP5 LRP6 FZD4 SDC2 tal-1 FZD5 GLI3 RFX2 MLXIP CHUK F2R TGFBR1 RELB TACR1 RYK ITGA4 APCDD1 GPR49 MTOR FZD1 NOTCH3 INSR PTPRB GPC1 PLXNA2 FZD7 ZIC2 SGK1 CSPG4 NOTCH4 SOX2 SDC1 PDGFRA NR3C2 S1PR3 HIF3A CELSR1 ITGB1 NLK LEF1 CDH6 BMPR1A KREMEN1 RAF1 FZD8 PMC4480196__F2 Pharmacologically targetable regulatory checkpoints of the mTOR pathway TSC2 TSC1 PTEN HIF1A RHEB PMC6621796__F11 Schematic drawing to illustrate JAK-STAT signaling pathway IRF9 GFAP MCL1 PMC7759999__F1 Opsonized epithelial apoptotic particles and ICs containing nuclear autoantigens bind to plasmacytoid DCs (pDCs) and RF B cells via TLRs and Fc receptors, respectively PDC BCR GC PMC3464089__F2 Aberrant activation of the MAPK signaling pathway in papillary thyroid tumor cells RET BRAF NTRK1 PMC7497849__F3 CCL5-VEGF-A signaling pathway in BEV treatment CCR5 VEGFA KLF13 CCL3 PMC11921692__F4 USPs and p53 signaling pathway USP4 CYLD USP9X MDM2 RBM28 USP36 HIF1A USP11 USP22 PMC11921692__F3 USPs and Nrf2 signaling pathway USP15 USP16 KEAP1 USP25 USP29 RBX1 USP11 PMC9240190__F6 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy MCUB MCU RYR2 PMC11921692__F2 USPs and TGFB signaling pathway USP4 USP26 USP15 CYLD SMAD2 SMURF2 USP9X SMAD4 TRAF6 SMURF1 USP11 TRAF4 PMC9240190__F5 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy SMAD2 SMAD4 ADAM10 RHO PMC11921692__F1 USPs and NFKB signaling pathway USP4 USP15 USP19 TRADD IRAK1 RELB TRAF3 TRAF6 IRAK4 MYD88 USP25 USP11 USP18 RIPK1 CYLD TRAF2 PMC9240190__F4 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy MAF NLRP3 TLR4 KEAP1 TRAF6 MYD88 PMC4798945__F7 A model of the tumor suppressive functions of TGM2 in HMECTERT/ST/ER-RasV12 cells ATG12 CDKN1A SQSTM1 DKFZp686F0183 PMC9240190__F3 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy TSC2 ULK1 TSC1 NR1C1 RHEB CD36 SIRT3 PMC6266917__F3 Systemic effects of increased adiposity on EC progression ANGPT1 IGF1 LIF IL1B PMC9240190__F2 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy GSK3B PTEN IRS1 PMC6266917__F2 Contributions of activated/recruited stromal cells in endometrial cancer (EC) progression HGF CXCR4 CCND1 EMP2 CCL5 IL1B PMC7773816__F3 Effect of amino acids and their derivatives on T cell signaling ATF4 LCK ZAP70 MYC LAT PMC10907749__F2 Antagonizing the host immune response by T. gondii STAT1 SOCS3 SOCS1 STAT3 PMC7773816__F1 Role of amino acids and amino-acid catabolizing enzymes in T-cell activation AHR GC JAK3 PMC10907749__F1 Host immune responses to T. gondii infection TLR7 TLR4 TLR9 IRF8 UNC93B1 MYD88 PMC10907749__F4 T. gondii antigen alters the signaling pathway of the host cell NLRP3 CCR5 SOCS2 TLR4 ARG1 IFNG STAT3 PMC3887453__F2 Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress MEF2B NOX4 JUNB PMC8123284__F3 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis GPX4 SLC7A11 SLC3A2 TF PMC8123284__F2 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis FES TF CP PMC10854812__F10 Selected agents targeting the Fyn/CD133/PI3K/Akt/mTOR pathway TSC2 FYN PTEN MTOR RHEB PMC4826221__F9 Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells ATM CDC2 ATR PMC6780840__F3 Intracellular peptidoglycan (PGN) is detected by intracellular receptors and activates the NFKB signaling pathway in Drosophila melanogaster and human enterocytes RIPK2 REL TRAF2 PMC7299241__F3 Actions of IGF-1 in the Growth Plate and its Role in Postnatal Bone Elongation BAD IGF1 GSK3B MTOR PMC9589007__F5 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues SQLE CTRC LBR EBP DHCR24 MVK HMGCS1 TM7SF2 GGPS1 CYP51A1 HMGCR ACAT2 PMVK MVD DHCR7 FDPS FDFT1 CTRL MSMO1 PMC7253212__F5 Interaction of FXR signaling and pathways relevant for zileuton-induced hepatotoxicity LIPC MAP2K4 SLC27A2 PDK2 MYC ABCB11 ACOX1 GPX2 ABCG2 UGT2B7 ABCC2 CYP2B6 CES1 UGT2B10 IL1RN HNF1A SLC25A17 SLC22A5 NR1C1 TCF2 PLTP IGF1 LIPA ACADL CPT1A ACADVL SLC51B SLC27A1 PLA2G4F PPARG CD36 FABP1 PMC9589007__F4 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues CS CTRC PPM2C PDK2 NNT MDH2 FH MPC1 PDHA1 ACO2 HAGH hEMMPRIN OGDH ME3 PDHX DLAT SDHA L2HGDH ME1 ME2 SDHC DLD IDH3B SLC16A3 NR1C2 SUCLG1 SUCLA2 PMC5217037__F7 miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NFKB and sustains NFKB activation by decreasing Cylindromatosis expression CYLD TNF TRAF2 PMC7810939__F6 GSEA analysis and gene‐pathway regulatory network in the liver BRAF HADHB ALDH3A2 RPTOR PDPK1 GCDH ACOX1 DGKG ACADS LIPG GLA HK2 FASN PRKCI CTSK SOS2 CRK FOXO1 CALM1 DGKB IKBKB HEL-S-80p GPAT2 PHKB AGPAT4 CPT1A ACADVL GRB2 PRKAG2 SOS1 EHHADH PYGL SOCS1 PIK3R2 PMC9589007__F7 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues C4BPB PROS1 CD46 CFHR4 CFHR5 C4A CR1 CLU CD81 CFI FCN2 C9 CFHR2 C1QA CFD CFH F2 SERPING1 MASP2 CD55 C1S CFHR3 CFB MASP1 FCN3 MBL2 CPN1 CPB2 C8A CD59 C1QB CPN2 VTN CTRL C8G C6 C4BPA C1QC CFHR1 PMC3235520__F1 Proposed model of the type I interferon induction by HIV-1 and HIV-1-infected cells PDC TLR7 TLR9 CXCR4 IRF3 MYD88 PMC9589007__F6 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues F10 PROS1 F2R THBD F8 CLEC3B F9 PROC PPBP SERPINC1 PLAT A2M SERPIND1 F2 F3 VWF F11 SERPING1 SERPINA1 THBS1 KNG1 SERPINB2 F2RL2 FGA HRG TFPI PLAUR PLG BDKRB1 PROCR CPB2 F5 CTRL F7 BDKRB2 APOH SERPINF2 TF PMC4385831__F6 Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFA and ROS production RIPK1 TRADD RELB RIPK3 TNF TRAF2 PMC5331050__F5 NOD-like receptor signaling pathway NOD1 MAP3K7IP1 IL1B NOD2 TAB3 PMC5223597__F8 Proposed model for the role INPP5E plays at cilia TCTN1 SAG GPR161 B9D1 TMEM231 SMO MKS1 B9D2 INPP5E PMC10989355__F4 Molecular signaling pathways affected by electrical stimulation (ES) of peripheral nerves NGF GDNF BDNF PMC10989355__F2 Regulatory signaling pathways activating Schwann cells (SCs) response in peripheral nerve regeneration (PNR) CNTF PIEZO1 SRC SOX10 BDNF PMC10989355__F1 Pivotal signaling cascades in peripheral nerve regeneration (PNR) NGF FRS2 GSK3B GRB2 GDNF ARHA MTOR BDNF PMC5041313__F2 CB1 cannabinoid receptor signaling and regulation of neural stem/progenitor cell proliferation GSK3B SRC RAP1GAP STAT3 PMC3712043__F1 Activation of the IRS signaling cascade pathways TSC2 RICTOR ULK1 BAD TSC1 IGF1 SHE ULK2 EIF4E MTOR RHEB PMC5331050__F3 Toll-like receptor signaling pathway TBK1 TLR5 TLR9 TRAF3 TRAF6 IRF3 MYD88 TLR1 TLR3 TLR8 TLR7 TLR4 CD40 IL1B PMC6885362__F4 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells TH CDA IL3 APC TNF TGFA PMC6548820__F10 The proposed mechanism for the indirect pathway of allorecognition in the T cell areas of the spleen and LNs XCR1 TH DST PMC3000682__F7 Pro-inflammatory pathway induction by cAMP/PKA signaling in BSC-derived lesions COX2 IL1B PMC6885362__F3 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells CD14 CTSK CD6 TRAF6 IRAK4 IRF3 IL6 MIP RAC1 TNF CPO LBP CD40 CD80 FADD TIRAP PMC8786804__F5 Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions HOXB2 DNAJC7 opn NRXN1 ITGB6 RHO ITGAV ITGB1 HSF1 HOXA5 HEL-S-72p PMC11734361__F3 Tumor-associated-mycobiome mechanisms involved in triggering oncogenesis and cancer development NLRP3 CARD9 IL33 STAT3 PMC4709785__F1 Metabolic regulation of the pluripotent epigenetic landscape OGT UCP2 PMC11734361__F4 Tumor-associated-mycobiome regulates the physiological and immune responses of cancer through different signaling pathways STAT1 CARD9 BCL10 RASGRF1 SYK GIP GYS1 RAC1 JAK1 HRAS NOD2 HK2 PMC6433964__F3 Repair pathways and signaling in response to DSB induction by IR ATM BRCA2 RAD51 ATR PMC3397239__F2 Anaplasma phagocytophilum: deceptively simple or simply deceptive? CASP3 ROCK1 SYK CASP8 PMC8908320__F8 Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas ATM CDC2 MTOR ATR PMC2234385__F10 Model of TLR ligand activation of Kupffer cell–NK cell cross talk in co-culture LTA TLR4 MYD88 TLR3 PMC8524136__F10 Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism DUSP9 SMTNL1 IRS1 PMC4166537__F4 CCR-14-0330R1: Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer ANK2 WDR12 DDX1 EGFR TRRAP CSMD3 AHNAK RPS11 RB1 LAMA4 STAG2 FAT4 NKD1 PI3 SYNE1 EP300 BRPF1 ATM CUBN PTPRU CHD6 PMC8836812__F4 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis FLT4 EGFR CXCL8 CCL5 IL11 CCL2 CCL1 BMP4 CXCL13 IL16 CCL24 NGFR GDF15 BMP5 IL4 CSF2 HMGB1 IL10 PIGF KIT IL13 BMP7 CCL4 IL6 TNFRSF11B TNF IL15 IL7 LTA TIMP1 CCL15 IGFBP1 TNFRSF1A IGFBP4 CXCL9 IGFBP2 GH1 IGFBP6 TGFB1 LTBR CP PROK1 PMC8836812__F3 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis NGF FLT4 CXCL8 CCL2 CCL1 IFNG IL16 CSF1R CCL24 BMP5 CSF2 IL1A VEGFA HBEGF CCL4 TNF IL12B IL15 NTF4 NTF3 TIMP1 IGF1 CXCL9 GH1 TGFA BDNF TGFB1 CP PROK1 FGF4 EGF HGF CSF3 EGFR VEGFD INS IL11 IL12A BMP4 IL18 PDGFA NGFR IL17A IL2 KITLG IL4 FGF7 IL10 PIGF KIT CCL11 IL13 FGF2 BMP7 TNFRSF11B LTA IL7 CSF1 LTBR CCL3 PMC7644826__F2 Canonical WNT signaling APC GSK3B LRP5 LRP6 PMC5127148__F1 Expression of myogenes in longissimus dorsi muscle during prenatal development in commercial and local Piau pigs IKBKB RSPO3 LEF1 MAP2K1 SUFU CHD8 EID2B CSRP3 SOX7 MYOG HIF1AN PMC8470542__F10 Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy ARG1 NQO1 PMC7019133__F1 Canonical Wnt/Beta-catenin pathway APC LRP5 LRP6 PMC7019133__F3 Role of sFRP2 in cardiovascular disease FZD5 PMC5129466__F1 Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF1R) signalling pathway IGF1 GSK3B GRB2 PMC5774495__F4 Osteoclast differentiation signaling pathway CTSK CYLD BASH IRF9 SYK RAC1 TRAF2 IFNG PMC5956974__F11 Function of the hub genes in the cell cycle signaling pathway visualized in the Kyoto Encyclopedia of Genes and Genomes (KEGG) map obtained by the Database for Annotation, Visualization and Integrated Discovery (DAVID) MOS PCNA MAL PMC3797434__F7 IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis TBK1 IRF7 TRAF6 IRF3 IRAK4 MYD88 PMC7784358__F5 KEGG pathway enrichment analysis and pathway map for RA CTSL CTSK CCL20 LTB PTH IL6 CTLA4 CCL2 ELL PTER CCL3 PMC11663348__F1 Stimulation by oral pathogenic bacteria induce dysfunctional PDLFs NLRP3 TLR4 RIPK3 RASA4 ECSIT PANX1 NOD2 MLKL STAT3 PMC5661640__F4 General overview of the process of cell death in SMA BAD PTEN MTOR PMC5661640__F3 Schematic presentation of suggested pathways of PTEN involvement in neuronal survival BAD CCND1 PTEN MTOR PMC3136563__F12 Working model for the role of USP4 in the negative regulation of TNFAlpha-induced TAK1 polyubiquitnation and NFKB activation USP4 USP15 USP21 TRADD TNF USP11 MAP3K7IP1 TRAF5 CYLD RELA CSA2 REL TRAF2 TAB3 PMC11580480__F8 Summary chart SMAD2 EGFR SMAD4 PMC6629629__F3 Clinical update on head and neck cancer: molecular biology and ongoing challenges CDK2 EGFR MDM2 CDK4 MTOR CDKN2A CDK6 PMC10382538__F7 Schematic model of the anti-inflammatory effects of IL4I1 on LPS induced-ALI AHR IFNGR1 PMC6629629__F2 Clinical update on head and neck cancer: molecular biology and ongoing challenges HGF EGFR MDM2 GRB2 PTEN MTOR PMC9682773__F4 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development AHR TG PMC8798411__F5 Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma PABPC3 CENPM ZNF479 CASP12 PCDHA8 PCDHA6 WNK1 CNOT1 RANBP2 WWTR1 KRT18 ZNF778 ZNF117 PABPC1 BCR SRA1 GAB2 ZNF880 ZNF492 ETS2 PCDHGA2 PCDHB13 PCDHGA10 PCDHB16 PMC9682773__F3 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development AHR TG PMC9682773__F2 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development AHR CYP1A1 PMC9601130__F1 Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC) KIF7 SUFU GLI3 SMO PMC6347823__F7 A schematic model showing the effects of duodenal ghrelin on hepatic glucose fluxes and insulin signals CCK NTS INSR PMC3074487__F8 Migration of FGF7-stimulated epithelial cells and VEGF-A-stimulated HUVECs depends on EGFR transactivation by ADAM17 EGF EGFR SRC HBEGF ADAM17 PMC9233299__F7 Beta-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes SIRT5 SDHB PMC7760327__F1 Cellular copper homeostasis in hepatocytes (A) and fibroblasts (B) CS ATP7B SCO2 COX17 SCO1 ATP7A CTRL ATOX1 HEL-S-44 CP CCS PMC9437524__F1 Neutrophil extracellular traps: New players in cancer research HMGB1 TLR9 MMP9 CTSC CCDC25 PMC6541606__F7 Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin A5 in hepatocellular carcinoma IL6 TNF PMC6433964__F2 Regulation of PD-L1 expression in response to DNA damage in cancer cells CGAS ATM ATR PMC7002344__F10 Differential phosphorylation of MAPK pathways during response to cell wall damage CIB2 ROM1 PAF1 CDC42 PMC12113985__F7 Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway DPP4 EHHADH ACOX1 PMC8130364__F1 Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy MTAP BRAF ZEB2 PMC8740229__F2 Targeting TREM2 for Parkinson’s Disease: Where to Go? NLRP3 TLR4 PMC3234798__F9 miR-26a pathway in the initiation of ASMC hypertrophy TH CTDSP2 EGR1 GSK3B