HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 IER3 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF HEL-S-281 INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HCTP4 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 PLOD2 PLOD1 SDC1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 GJA1 GIG8 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 MCM7 ITGB3 TNFAIP3 LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 opn DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 TAGLN PCOLCE2 LAMA1 LAMA3 THBS2 THBS1 FSTL1 PTHLH NOTCH2 FSTL3 NT5E ABI3BP GPC1 SPOCK1 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A ATF1 HEL-S-71 CDC2 GSK3B ARF1 CDKN1B CLTC UBE2D3 PRKAG1 HRAS PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR FGF6 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 ACTR3 ACTR2 PLA2G12A DUSP3 NCK1 PRKCB TSC2 TRAF2 IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 PIK3R3 DAPP1 NOD1 IL2RG HEL-S-99n EGFR DDIT3 ACACA HEL-S-15 GNA14 MAPK9 MAPK8 TRIB3 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 PAK4 SMAD2 STAT2 PTPN11 FGF17 HEL-S-47e MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 CDK2 PIN1 GRB2 MYD88 NFKBIB SFN TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS VEGFA CDC2 IER3 CXCR4 EGFR DDIT4 AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 PHKA2 SAP30 TPST1 CLDN3 CLDN9 PLOD2 RRAGD PLOD1 PKP2 SDC1 KDELR3 ENO2 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN P4HA2 HEL20 GALK2 LHX9 QSCN6 B4GALT2 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 PGM2 ME2 TGFBI GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANG ANGPTL4 ALDOB CHST4 LCT DLD B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE GLRX NOL3 CENPA DCN CLN6 MXI1 GPC3 GPC4 EGLN3 VCAN SLC35A3 B3GAT3 MDH2 BIK AGL TPBG CD44 B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC PSMC4 CTH AGRN POLR3K NT5E PFKP GPC1 HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING NOTCH4 HDAC11 LEF1 PSEN2 RBPJ NR1C2 hCG_2014051 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 NOTCH1 AXIN2 DKK4 NCOR2 ADAM17 KAT2A NUMB DKK1 JAG2 CCND2 FZD8 HDAC5 HDAC2 MAML1 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 CFTR DPEP3 DDX4 ALOX15 ART3 GMCL1 OAZ3 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 COIL SHE HEL162 GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 TTK NPY5R AURKA DCC HSPA4L PARP2 ELOVL3 SIRT1 MLF1 TSN ARL4A DBF4 CAMK4 MEP1B DMC1 ACRV1 TULP2 CST8 AKAP4 HEL-S-278 hCG_1641087 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A APP SPTAN1 CCND2 FDXR IER3 SQSTM1 F2R DDIT3 TXNIP ATF3 ROCK1 NEFH RETSAT NEDD9 TNFSF6 CDK2 HMOX1 JUN GADD45A IFITM3 PRF1 PLAT BMP2 CLU TNF CCND1 TNFSF10 BNIP3L HGF ENO2 CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BTG2 BCL10 CDKN1A EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 IRF-1 BRCA1 CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA IL1A GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 AVPR1A F2 DNAJC3 HEL-75 GADD45B IL1B DPYD RARA ETF1 PLCB2 BIRC3 IL6 RNASEL GUCY2D SATB1 SLC20A1 PLPPR4 CASP6 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 CD2 WEE1 KRT18 CD69 BAX TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 BIK CD44 HEL-S-44 CTH HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT NOTCH4 PCSK9 CD59 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL HNF4A KYNU CTSH OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-76 DOCK4 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 HEL-S-130P L3MBTL4 C1QA USP14 CEBPB USP15 USP16 SCG3 C1S SERPINC1 TMPRSS6 SRC WAS GNAI3 PLG RNF4 LCK PPM2C GNG2 SPOCK2 CCL5 PFN1 FYN RAF1 SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG PSMB9 GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 IRF-1 CASP9 CASP3 CASP4 F2 TFPI2 IL6 ME1 TNFAIP3 DGKG FCN1 CXCL1 CDA GMFB C4BPB LIPA HEL110 DOCK10 CDK5R1 LAMP2 ANG PIM1 ACTN2 GPD2 TIMP1 FDX1 ADAM9 SERPING1 LAP3 S100A9 CFB CFH KLK1 GATA3 PLAUR PLA2G7 PIK3R5 DPP4 VCPIP1 PPP4C C9 S100A13 S100A12 RCE1 STX4A MMP14 LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 ITGAM CPQ DOCK9 PLEK HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 MYC PLK1 CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 AURKA CHEK1 NBN LIG1 HUS1 ILF3 DDX39A MSH2 CDK4 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B CENPE RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 PLK4 HEL25 CDKN3 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 STAG1 KIF18B UBE2S CDC25B UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 CDKN1A HMGB3 PSIP1 CTCF CKS1B CROP ING3 MYBL2 TK1 LBR POLE HMMR TCF19 HELLS RFC3 RFC2 EED TUBB TUBG1 CIT MMS22L CKS2 HMGB2 MCM3 MCM5 BRCA1 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB UNG POLD3 PSMC3IP TRA2B EXOSC8 NASP RAD51C POLD2 PPP1R8 USP1 PMS2 RBBP7 E2F8 GINS1 PCNA H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 PPM1D GINS4 DONSON RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A RPA3 BRMS1L RQCD1 TACC3 CDKN2A CENPM RAD1 MCM7 WEE1 TRIP13 RAN SPC24 MAD2L1 SPC25 DEPDC1 SMC3 SMC4 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT CCNB2 SLC7A1 HIRA PURA WRN CDC45 NSD2 E2F2 DMD E2F3 E2F4 MYC SRSF10 GINS2 CASP8AP2 PLK1 H2AZ2 POLS EGF MAPK14 PML CUL4A CDC2 MEIS1 pk CDKN1B TOP2A NUMA1 KIF11 BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 EZH2 JPT1 PAFAH1B1 MKI67 CDC20 PTTG1 TTK AURKA CHEK1 HUS1 ILF3 DDX39A KATNA1 CDK4 DBF4 SLC12A2 NOLC1 TGFB1 PDS5B CENPE MARCKS ORC6 CENPF RAD21 PRC1 BARD1 PLK4 CDKN3 HMGA1 SAP30 CCND1 POLA2 STAG1 UBE2S CDC25B HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B MYBL2 LBR POLE HMMR CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB TRA2B NASP H2AZ1 CDKN2C TACC3 MAD2L1 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 HMGN2 TLE3 SLC38A1 SMARCC1 PRP4K SMC4 KNL1 TRAIP DKC1 EWSR1 NCL CDC27 NUP98 NUSAP1 ATF5 CUL5 NEK2 YTHDC1 TROAP FBXO5 EFNA5 HIF1A CENPA STIL UBE2C HEL-S-61 CBX1 CDC6 KNTC2 FOXN3 SQLE UCK2 MNAT1 SETD8 AMD1 HOXC10 CHAF1A CHMP1A TNPO2 SS18 RBM14 HEL-S-72p KIF20B HEL164 H2BC12 CCNA2 SLC7A5 NOTCH2 SFPQ RBL1 TFDP1 DTYMK HCTP4 DKFZp666G145 HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 AQP7 CPOX UBE2L6 ENO3 IL4I1 TDO2 HEL-S-53e HEL-76 UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL RETSAT HSDL2 HMGCS1 ELOVL5 CYP4A11 NBN FACL4 HEL-S-25 INMT HADHB UGDH ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD HSD17B4 HEL-S-278 LTC4S HSD17B11 S100A10 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH PCBD1 ACSS1 AADAT G0S2 EPHX1 GAD2 FABP1 GSTZ1 FABP2 SUCLA2 SDHC APEX1 CRAT METAP1 ENO2 HEL-S-133P H2AZ1 HEL-S-32 ME1 HEL-S-26 GPD2 DLD ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB VEGFA MYC KYNU OLR1 PTX3 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 CCL5 IER3 SQSTM1 TNLG5A NINJ1 ATF3 JUN GADD45A MARCKS PLK2 G0S2 LIF PTPRE CD83 BMP2 CSF2 TNC CSF1 TNF CD80 CCND1 ETS2 IFIT2 ZFP36 ZC3H12A MXD1 CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A BTG2 PHLDA2 CDKN1A CCNL1 BTG1 PHLDA1 GIG8 JUNB IER2 IL15RA IL23A SIK1 PLPP3 TRIB1 MCL1 IL6ST BHLHB2 FUT4 SOCS3 SNN MSC ABCA1 GEM EGR1 EGR2 TIPARP BTG3 TNFRSF9 NFKB1 IRF-1 SPHK1 NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 FOS RCAN1 YRDC CXCL11 NR4A3 IL1A SDC4 BCL6 GPR183 REL NFKBIE IL7R NFE2L2 IL18 HBEGF RIGI PPP1R15A TNFAIP6 TNFAIP2 SLC2A3 B4GALT1 CXCL3 LITAF GADD45B SLC2A6 IL1B CXCL2 PANX1 IFIH1 INHBA PDE4B KLF10 BIRC3 IL6 TGIF1 DUSP4 KDM6B EDN1 DRAM1 DUSP2 RIPK2 RELA IFNGR2 TRAF1 SERPINB8 TUBB2A SGK1 FJX1 BIRC2 CXCL6 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD TNFAIP3 PTGS2 KLF4 CD69 TANK CXCL1 SUI1 RELB AREG NFIL3 CYR61 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 CCL20 ATP2B1 KLF2 PNRC1 PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 PLAUR TRIP10 ACKR3 F2RL1 FOSB RHOB TMEPAI CD44 EHD1 MAFF PLEK HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING ETS2 MYH9 VEGFA HEY2 PTCH1 PML NF1 CDK5R1 TLE3 OPHN1 SCG2 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 THY1 CELSR1 AMOT SHH SLIT1 NRCAM PLG NKX6-1 L1CAM CDK6 VLDLR HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS GPX8 SREBF2 ETHE1 PPARG STX5A MVD ACSS2 MVK SEMA3B GNAI1 LPL HMGCR EBP ATXN2 PMVK TP53INP1 HEL-S-7 MAL2 FDFT1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 SCD CD9 DHCR7 CPEB2 PLSCR1 IDI1 AVPR1A ACAT2 FASN GUSB SC5D TRIB3 ATF3 NFIL3 HMGCS1 LDLR PNRC1 TNFRSF12A ATF5 PLAUR HSD17B7 SQLE PDK3 GLDC TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 CLU HEL-S-4 STARD4 PCYT2 HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 NPFFR2 CSF3 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IRF7 IL18RAP LCP2 CD82 RGS1 LAMP3 CLEC5A C3AR1 PROK2 ROS1 SCN1B KIF1B CMKLR1 IL1R1 SLC11A2 CYBB IFNAR1 LY6E GNAI3 CALCRL EBI3 C5AR1 LCK FPR1 LPAR1 SLC1A2 CCL5 MEFV RAF1 HRH1 IRAK2 CD55 NLRP3 TNLG5A NDP MSR1 FZD5 EIF2AK2 NMI SELE ARHG BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 SRI ATP2C1 HEL-S-75 SLC7A2 CCL7 P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 SEMA4D SLC31A2 SLC31A1 PCDH7 LIF IL10RA ADRM1 OSM OPRK1 ACVR2A PTPRE P2RX7 P2RX4 AXL CSF1 IL2RB TNLG8A TNFSF10 VIP IL18R1 MXD1 CCRL2 EREG NAMPT IL12B PSEN1 BTG2 CDKN1A IL15RA CD14 ABCA1 TNFRSF9 NFKB1 IRF-1 SPHK1 NFKBIA CXCL11 IL1A GPR183 IL7R IL18 HBEGF TNFAIP6 RGS16 IL1B INHBA PDE4B ACVR1B IL6 EDN1 RIPK2 RELA IFNGR2 GNA15 CXCL6 CXCL8 PTGER4 ITGB3 CD69 ADORA2B CCL2 LDLR CCL20 TIMP1 ATP2B1 IL15 KLF6 PLAUR PIK3R5 EMP3 HIF1A GPC3 MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 SPTBN1 ACVR1 SMAD1 GIG8 JUNB WWTR1 SMURF2 SMURF1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 NCOR2 FKBP1A SKI UBE2D3 RAB31 ARHA ID1 ID3 BMPR1A ENG MAP3K7 TGFB1 TMEPAI PPP1R15A APC THBS1 KLF10 TGIF1 BMP2 SLC20A1 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE PML UBE2L6 PLSCR1 IRF2 IRF7 LCP2 CMKLR1 C1S IFI30 LY6E FPR1 CCL5 EIF2AK2 GZMA NMI TRAFD1 BST2 PSMB9 NOD1 RTP4 CD40 CXCL9 TXNIP RAPGEF6 RIPK1 STAT2 TAPBP ARL4A MTHFD2 SOCS1 MYD88 SRI CCL7 IL10RA IFITM3 IL2RB TNFSF10 IFIT2 RBCK1 NAMPT CDKN1A BTG1 IL15RA SOCS3 SAMD9L IFITM2 NFKB1 IRF-1 SPPL2A IFI35 IFIT1 NFKBIA CASP8 IFIT3 CASP3 PNP CASP4 DHX58 EPSTI1 ISG20 TRIM25 CXCL11 VAMP8 TRIM26 CMTR1 B2M TRIM21 HERC6 ZBP1 IFNAR2 RSAD2 RIGI SP110 TNFAIP6 HLA-B TNFAIP2 ARID5B VCAM1 HLA-A HLA-G NUP93 IFI27 PSME2 CMPK2 IFIH1 TRIM14 PDE4B IDO1 CSF2RB IL6 HELZ2 KLRK1 RNF213 ST8SIA4 ISOC1 RIPK2 SLAMF7 ST3GAL5 HLA-DQA1 PNPT1 AUTS2 IFI44 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 SELP TNFAIP3 PTGS2 CD69 IL7 SSPN XAF1 GPR18 MT2A HLA-DRB1 LGALS3BP OGFR CCL2 EIF4E3 SECTM1 PIM1 ADAR OASL IL18BP ITGB7 BATF2 SERPING1 TMT1B LAP3 LATS2 IL15 BANK1 CFB OAS2 CFH PSMA2 IRF4 OAS3 PELI1 XCL1 HIF1A IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HLA-DMA SLC25A28 APOL6 PSMB2 STAT4 FCGR1A GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PFKP PSMB8 ZNFX1 PTPN6 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN IRS1 SLC7A1 PRDM2 NR3C1 IGF1R PPARG ZMIZ1 AKT3 CAP2 CDON IGFBP5 SFMBT1 PRKCE MYC DYRK1A PRKCA COL3A1 RUNX1 INPP4B MAP1B POLS PMP22 SCN8A AMPH MAPK14 MT1E PTGFR INSIG1 CACNA1A KALRN LTBP1 CDKN1B ATXN1 GRK5 F3 MAP2K5 DMAC2L PTEN FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 PLCB4 MMP16 KCNMA1 KIT GCNT1 LPAR1 MRPS31 TFPI ADD3 FYN SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 PIK3R3 RASA2 MGLL SRI ATP2C1 HAS2 CDC42BPA ACVR2A RGS4 GJA1 SDC2 PLPP3 TJP1 BHLHB2 ID1 BMPR1A NFKB1 FBLN5 CITED2 BDNF VLDLR COL1A1 COL1A2 RXRA COL5A2 SNAI2 ERBB2 ITGB3 LAMC1 ADORA2B CYR61 LDLR ATP2B1 YTHDC1 NRP1 TGFBR3 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING IL18R1 MAP3K8 CD36 IL15RA CD14 IL6ST SOCS3 CD9 CSF3R IRF-1 CXCL11 IL1R1 IFNGR1 STAM2 IFNAR1 CXCL3 TNFRSF1A EBI3 IL1B ACVR1B CSF2RB IL6 ACVRL1 IFNGR2 CXCL13 LEPR ITGA4 IL2RG IL1R2 BAK1 DNTT TYK2 IL17RB CXCL9 IL17RA IL3RA LTB ITGB3 TNFRSF21 HAX1 IL9R CBL IL7 CXCL1 CSF2RA PDGFC IL12RB1 A2M CCR1 IL10RB STAT2 PLA2G2A PTPN11 INHBE PIM1 IL2RA TNFRSF1B LTBR OSMR CRLF2 PF4 TNFRSF12A SOCS1 GRB2 MYD88 PIK3R5 HMOX1 CNTFR IRF9 CCL7 JUN TGFB1 CD44 IL13RA1 PTPN1 STAT1 STAT3 CSF2 CSF1 TNF HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 RFC4 AK1 LIG1 ARL6IP1 MPG XPC GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 POLR3GL ALYREF UPF3B SUPT5H ZWINT ADRM1 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 POLA2 SNAPC5 MRPL40 GUK1 SNAPC4 REV3L DKFZp781O1323 ADA DGCR8 ELOA NELFB POLL NELFCD NELFE NCBP2 NME3 VPS37D NME4 EDF1 VPS37B AK3 APRT NT5C3A SEC61A1 DDB1 RRM2B NFX1 RFC3 POLR1C RFC2 POLR1D HCLS1 POLR1H UMPS RALA CANT1 GTF3C5 RNMT PRIM1 USP11 DCTN4 GMPR2 TAF9 PNP TYMS ADCY6 DDB2 POLD4 POLD3 POLR2A POLR2C POLR2D POLR2F GPX4 POLR2G POLR2H POLR2I POLR2J RAE1 POLR2K BRF2 PCNA TAF12 PDE6G TAF13 DUT TAF10 GTF2H3 GTF2H5 CMPK2 TARBP2 PDE4B RAD52 RAD51 POLR3C IMPDH2 ERCC1 ERCC2 SSRP1 TAF6 DFNA5 POLE4 NUDT21 RPA3 BCAP31 CDA ERCC5 HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS HSPB8 ETFB GPHN AIFM1 PPARG ALDH2 NKIRAS1 DBT DLAT YWHAG LPL ADIG COX8A JAGN1 CHUK CD36 HEL-S-104 ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 SMVT PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 CAVIN1 NDUFA5 CAVIN2 SUCLG1 RIOK3 SQOR VEGFB IMMT DHRS7 PFKL GPAM ADIPOR2 CCNG2 LEP LPCAT3 NDUFAB1 ATP5PO DECR1 ESYT1 PEX14 CIDEA HEL-S-62p ACO2 REEP6 ACADL CPT2 ACADM ACADS RETSAT ARL4A ACOX1 MGLL ECHS1 LTC4S AK2 GADD45A SDHC CRAT MYLK ABCA1 COL4A1 ADCY6 BCL6 GPX4 GPX3 IFNGR1 CDKN2C TOB1 SCARB1 ME1 MTCH2 SLC27A1 STOM ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 HEL-S-26 MCCC1 OMD ATP1B3 TANK CMBL SSPN SDHB ACLY POR ADFP CMPK1 UQCRC1 SLC25A10 SPARCL1 PREB ANGPTL4 RTN3 GPD2 CD151 MTARC2 MGST3 DLD ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 HEL-S-87p BCL2L13 GRPEL1 DHRS7B UBC G3BP2 APOE CYC1 RREB1 SLC19A1 ESRRA FZD4 HEL107 EPHX2 MDH2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS HEL-S-44 COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION CTSS HEL-S-71 IRF7 IL18RAP LCP2 MAP3K7 PRKCB NCK1 CCND3 CCND2 TRAF2 WAS CD1D LCK GCNT1 CCL5 SPI1 GPR65 NLRP3 NCF4 UBE2D1 RPL9 F2R IL27RA GZMA RPS19 SIT1 CXCL13 IL12A HLA-DOA HLA-DOB IL2RG CD40LG RPL39 TPD52 EGFR CD96 RPS9 CD40 KRT1 CXCL9 TAP2 CARTPT LTB HLA-E CD8B CD8A STAB1 AARS1 IGSF6 CFP IL12RB1 CD79A ELANE CCR1 IL10 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L IL4 PTPRC TAPBP PF4 IL9 TLR1 TNFSF6 DEGS1 KLRD1 ITK FLNA DYRK3 SOCS1 CD3G TLR3 CD3E CD3D IKBKB MRPL3 CCR5 CCR2 MBL2 EIF5A MAP4K1 CCL7 SRGN IL11 IL13 IL16 TGFB1 RPS3A MMP9 NCR1 ZAP70 CCL22 IFNG ELF4 CD47 RARS1 BCAT1 LIF CCL13 CCL11 INHBB MTIF2 HLA-DMB CXCR3 ACVR2A PRF1 CSK CCL19 GBP2 CSF1 TNF NPM1 IL2RB CD80 NOS2 TRAT1 GALNT1 c-fgr CD7 EREG EIF3J ABCE1 FCGR2B IL12B EIF3D EIF3A BCL10 HCLS1 HEL-S-66 BRCA1 B2M THY1 IFNGR1 IFNAR2 IL18 F2 HLA-A HLA-G IL1B INHBA IL6 ST8SIA4 RIPK2 IFNGR2 HLA-DQA1 CDKN2A CD2 IL7 CCL4 CCL2 TIMP1 IL15 IRF4 HIF1A IRF8 ACHE LYN PSMB10 HLA-DMA STAT4 CD74 STAT1 PTPN6 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE IFIT2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 CNP SAMD9 UBA7 GMPR MVB12A MOV10 UBE2L6 IFITM1 SAMD9L IFITM2 IRF-1 PLSCR1 IFI35 CASP8 IRF2 IFIT3 IRF7 DHX58 LAMP3 EPSTI1 ISG20 TRIM25 CXCL11 TRIM26 CMTR1 B2M TRIM21 HERC6 C1S IFI30 RSAD2 SP110 LY6E IFI27 PSME2 IFIH1 CMPK2 TRIM14 HELZ2 EIF2AK2 RIPK2 NMI TRAFD1 PSMB9 BST2 PNPT1 SELL PROCR IFI44 RTP4 ISG15 TDRD7 PARP14 TXNIP PARP12 IL7 LGALS3BP OGFR STAT2 ADAR OASL BATF2 LAP3 IL15 IRF9 RNF31 USP18 SLC25A28 CD47 GBP4 CD74 IFITM3 MX1 GBP2 PSMB8 CSF1 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY HSPB8 NHERF1 ZNF185 AMFR IGF1R KRT13 SNX24 DHRS2 KLK10 DHRS3 SEMA3B TTC39A KRT19 MYC MLPH MYBBP1A CHPT1 RAB17 GLA FDFT1 FRK TJP3 NCOR2 DHCR7 FHL2 ABAT SLC22A5 ADD3 FASN IL17RB ELOVL5 FLNB SFN SLC19A2 FARP1 SLC7A2 P2RY2 INHBB CCND1 FKBP4 GJA1 ELF1 PMAIP1 IGFBP4 IL6ST BHLHB2 FCMR WWC1 HR RAB31 NADSYN1 STC2 AQP3 CELSR2 RAPGEFL1 CANT1 SOX3 TIPARP DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU FOS MREG CISH ATL1-beta NPY1R KAZN KCNK15 OVOL2 SULT2B1 OLFM1 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 B4GALT1 SLC27A2 PTGES FKBP5 SLC26A2 RARA HEL-S-10 MINDY1 ARL3 KLF10 ABHD2 SLC1A1 TOB1 ENDOD1 ISG20L2 CXCL12 RHOBTB3 SLC1A4 SCARB1 UGCG SYNGR1 CALCR INPP5F ALDH3B1 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 KRT18 ABCA3 KLF4 GREB1 MED24 TPD52L1 MED13L ELF3 REEP1 KCNK5b AREG BCL2 TFF3 UNC119 RETREG1 RP13-360B22.2 HES1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 DYNLT3 ELOVL2 ITPK1 MYOF PLAAT3 GAB2 NAV2 CBFA2T3 RHOD ESRP2 MPPED2 CELSR1 TFF1 FOXC1 SLC24A3 TMPRSS3 TPBG CD44 ASB13 ADCY1 PAPSS2 THSD4 TIAM1 MUC1 PDLIM3 OLFML3 LRIG1 RBBP8 SLC7A5 SH3BP5 EEIG1 MICB CA12 SVIL KDM4B HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA NR3C1 RBPJ VEGFA PRKCA TES MT1E RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 CDKN1B TPST2 BCAN F3 ENO3 PPP1R3C PKP1 LXN HACL2 PRDX5 LARGE PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX NCAN HEXA HEL-S-134P PYGM BRS3 AKAP12 CSRP2 CAVIN1 STBD1 ATP7A EDN2 ANXA2 GAA AMPD3 LALBA FBP1 CHST3 PFKL TMEM45A FOXO3A KDM3A CCNG2 DGIC HAS1 NOCT GCNT2 VHL IER3 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 CXCR4 NAGK INHA MYH9 XPNPEP1 TPD52 EGFR DDIT3 DDIT4 S100A4 ADM ATF3 HMOX1 ERO1A HEL-S-278 HEL-S-75 ZNF292 ENO1 JUN HEL-S-89n DPYSL4 PDK3 SAP30 RRAGD BNIP3L ZFP36 KDELR3 CDKN1C ENO2 CTGF CDKN1A BTG1 SDC2 SDC3 STC1 AK4 BHLHB2 STC2 ANKZF1 TIPARP FOSL2 CCN5 HEL-S-133P EFNA1 B3GALT6 FOS EXT1 ISG20 EFNA3 SDC4 P4HA1 SULT2B1 P4HA2 PPP1R15A SLC2A3 CITED2 VLDLR HK2 IL6 GYS1 CASP6 SCARB1 PGM2 TGFBI PGAM2 HEL-S-68p SIAH2 HEL-S-19 TNFAIP3 ADORA2B NFIL3 MT2A BCL2 CYR61 ADFP PIM1 ANGPTL4 ALDOB PNRC1 KLF6 HEL-S-87p PLAUR GLRX ACKR3 DCN MXI1 GPC3 GPC4 TPBG CP HEL-S-49 MAFF SLC25A1 PFKP CA12 GPC1 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE VEGFA IGFBP1 HEL-S-125m DNAJB9 CEBPB TSPYL2 EIF4A2 EIF4A1 POP4 EIF4A3 HEL-S-99n RRP9 EDC4 RPS14 DDIT4 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ATF3 EIF4E ERN1 NHP2 ATP6V0D1 TARS1 ATF4 HEL-S-93 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS EDEM1 LSM1 ASNS MTHFD2 EEF2 LSM4 CNOT4 CNOT6 CNOT2 ERO1A SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 HEL-S-89n SERP1 NOLC1 WIPI1 SKIC3 EXOC2 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 SEC11A EXOSC1 EIF2S1 PAIP1 NFYA NPM1 NFYB SPCS3 SPCS1 XPOT KDELR3 DNAJA4 PSAT1 H2AX CKS1B STC2 IFIT1 DNAJC3 NOP56 SLC1A4 TUBB2A XBP1 WFS1 CCL2 PREB DKC1 HEL-S-61 NABP1 SLC7A5 HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE PCSK9 AKAP7 IL2RG LYPD3 SLC2A4 PKHD1 SCUBE1 FLOT2 ATP6V0A4 EPHB4 CX3CL1 TMEM8B NTNG1 SLC34A3 ATP8B1 CD160 NCOA6 ADAM10 SULF2 RTN4RL1 CROCC MAL GHRL RHCG MDGA1 BRCA1 APP GATA3 PLAUR SRPX EFNA5 HEL-S-102 THY1 LYN GAS1 B4GALT1 ADIPOR2 SHROOM2 GSTM3 IL2RB HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM SNCA RBM38 NR3C1 DMTN SMOX MOCOS FOXJ2 E2F2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 SLC25A38 SLC25A37 TSPO2 XK HEL-S-2a RHAG YPEL5 LPIN2 TNRC6B CPOX HEL-76 UROD ICAM4 UCP2 HEL-S-134P MAP2K3 USP15 RIOK3 SLC11A2 CCND3 ARHGEF12 FOXO3A UROS HEL-S-62p TFRC HBZ ASNS BCAM SDCBP HEL-S-304 BNIP3L BTG2 ABCB6 SLC7A11 H1-0 ISCA1 AQP3 NARF GDE1 SLC4A1 BACH1 NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 GCLC SLC30A1 GAPVD1 MYL4 MINPP1 P4HA2 RNF123 KEL PPP2R5B hEMMPRIN DAAM1 HMBS TRIM10 RHCE OPTN ABCG2 OSBP2 SIDT2 HEL-S-10 SLC22A4 EPB42 FECH GYPC IGSF3 ENDOD1 GYPB GYPE SLC6A8 DCUN1D1 HTRA2 ADD1 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP SPTA1 TSPAN5 HBQ1 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 LAMP2 SYNJ1 MKRN1 RANBP10 TMCC2 LRP10 MGST3 GCLM EZH1 NFE2L1 TMEM9B CDC27 PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 MXI1 ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 PC CLCN3 ADD2 AGPAT4 RHD TRAK2 MARCHF8 CIRSR DCAF10 HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION ANP32E COPB2 GLA CTSC ADAM10 ARF1 SNAP23 CLTA CLTC RAB22A IGF2R GOLGA4 SCRN1 AP1G1 ABCA1 PPT1 AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 AP2M1 ERGIC3 SEC22B VAMP4 ATP6V1B1 KIF1B VAMP3 ATP7A NAPA CD63 STX12 TMED10 SGMS1 STX16 DST COPB1 VPS4B USO1 ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 YKT6 ARFGEF2 MON2 CAV2 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A TPD52 EGFR GNAS YIPF6 RAB9A RAB5A COPE BET1 KRT18 MAPK1 SSPN LAMP2 SEC31A ZW10 ARFGEF1 TSG101 GOSR2 HEL-S-44 COG2 CLCN3 RNP24 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION IRS1 SLIT2 AKT3 MVD GNAI1 MYH10 MAPK14 INSIG1 pk NF1 PTEN WASL ICAM4 VAV2 SRC SHROOM2 RHOF PFN1 PIK3R3 MYH9 NF2 EGFR CTNND1 CX3CL1 ICAM2 INPPL1 LNIR PLCG1 HEL-S-79 DMP1 ICAM5 ACTG2 CDH8 TIAL1 FYB1 CDH4 SIRPA SHC1 NRTN HEL70 SCAP2 PTPRC ACTN1 CLDN6 CLDN5 CLDN4 ADAM15 CERCAM GTF2F1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK JAM3 RSU1 CD99 VASP CADM3 CDSN MMP9 JUP CADM2 PBX2 PARVA CDK8 ARPC2 TAOK2 CD209 CNTN1 COL16A1 COL9A1 ALOX15B PALS1 ADRA1B CRAT PKD1 SGCE TRO ADAMTS5 CLDN9 PS1TP5BP1 MDK DHX16 SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK CDH6 VWF HEL-S-20 TMEM8B ITGB4 KRT31 CLDN11 ACTA1 SDC3 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL TJP1 CDH15 NLGN3 NLGN2 AMIGO1 HRAS AMIGO2 TUBG1 NRXN2 PARD6G THBS3 LIMA1 ADAM23 NRAP CTNNA1 MPZL1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 PPP2R2C ZYX NECTIN3 TNFRSF11B NECTIN2 THY1 CRB3 NECTIN1 CLDN7 VCAM1 B4GALT1 BMP1 TRAF1 TGFBI FBN1 ITGB1 BAIAP2 LAMC2 LAMB3 HEL114 ACTN2 ADAM9 CALB2 ITGA2 MMP2 VCAN STX4A CDH11 TSC1 ACTN4 LAMA3 ACTG1 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS SRP9 SPCS1 G6PC2 MAFB SST IAPP AKT3 INSM1 FOXA2 NEUROG3 NR1i1 DPP4 SRPRB LMO2 PCSK2 PCSK1 STXBP1 SLC2A2 SRP14 NKX6-1 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PDX1 PKLR GCG ELP4 HNF1A GCK SYT13 ISL1 HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM NPC1 ANGPTL3 TMBIM6 ACOX3 SMOX ALDH2 CRP NR1C2 ITIH4 DDC KARS1 HEL-S-51e HNF4A CYP17A1 KYNU PGRMC1 DKFZp434B2017 SERTAD1 CD36 ATOH8 HSD17B2 XDH MARCHF6 CCL25 MPP2 NQO1 LPIN2 TMEM176B IGFBP1 PTGES3 F11 AKR1C2 HEL-S-182mP DHRS1 PINK1 TDO2 GSTA3 HEL-76 CDO1 CYFIP2 AQP9 DDT GABARAPL1 ALDH3A1 IL1R1 MAOA FBP1 DHRS7 PLG ADH7 TNFRSF1A GCNT2 F10 VNN1 CYP1A1 ACO2 NINJ1 ATP2A2 EPHA2 RETSAT SLC35D1 ELOVL5 UGDH ACOX1 ADH1C HMOX1 MBL2 BPHL PTS GAD1 PMM1 JUP EPHX1 BCAT1 FABP1 TPST1 ETS2 GIG8 IGFBP4 ARPP19 DCXR GCLC HEL-75 PTGES HEL-S-10 CASP6 RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 HEL-S-26 CNDP2 PDK4 LONP1 HEL-S-64p CDA MCCC2 HES6 TYR MT2A ENTPD5 POR SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SLC22A1 GSTT2 ABHD6 NDRG2 CYP2C18 CFB ADH5 ALDH9A1 HSD11B1 VTN pcap TTPA ASL CYP2J2 IRF8 APOE GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 CYP2S1 CYP1A2 PSMB10 HRG GUGU ABCD2 ALAS1 LEAP2 CROT PAPSS2 AOX1 ACP2 TMEM97 MAN1A1 HGFAC PC NMT1 ABCC3 ARG2 PEMT ABCC2 HEL-S-21 ARG1 DHPS SSR3 PTGR1 HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS COL5A2 MSX1 CXCL6 LPL VEGFA COL3A1 S100A4 OLR1 TNFRSF21 STC1 POSTN ITGAV TIMP1 PF4 PDGFA LRPAP1 THBD APOH PGLYRP1 VTN KCNJ8 APP PRG2 SLCO2A1 FGFR1 opn NRP1 JAG2 VCAN VAV2 CCND2 FSTL1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS HSPB8 PSEN2 DMD COL3A1 CD36 FDPS ITGA7 NQO1 SCD ENO3 PPP1R3C LARGE RB1 SCHIP1 APP ACSL1 COX6A2 SLN GJA5 PYGM MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 SPTAN1 MEF2C TPM3 GAA DAPK2 TSC2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 FLII AEBP1 FOXO4 COX7A1 CNN3 SYNGR2 IGFBP7 APOD EIF4A2 PRNP CAV3 DMPK OCEL1 MYH9 GNAO1 PKIA FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 HSPB2 ATP2A1 LDB3 MYL6B MYOM2 NOTCH1 CSRP3 SGCA BDKRB2 ANKRD2 HEL-S-101 AK1 MYBPC3 MYOG TEAD4 PTGIS RIT1 TNNC1 DENND2B TNNC2 HEL-S-29 SIRT2 MYH1 MYH2 PTP4A3 TNNT1 TNNT3 CASQ2 MYH8 PICK1 MAPRE3 CASQ1 KIFC3 MYH4 MYH7 TGFB1 CTF1 CKMT2 EFS CHRNG TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 LPIN1 SH3BGR SH2B1 SPARC SPDEF MYBPH CRAT PDE4DIP MAPK12 CLU MYO1C DES KLF5 FKBP1B TCAP HEL-S-273 PLXNB2 SPEG PFKM FGF2 MYLK CDKN1A ITGB4 WWTR1 ACTA1 BHLHB2 CACNA1H STC2 COL4A2 SPHK1 ADAM12 SORBS3 MYL4 GPX3 ADCY9 HBEGF GADD45B COL1A1 SLC6A8 TNNI1 ERBB3 BAG1 ITGB1 PGAM2 TPD52L1 SSPN REEP1 SGCD ACTN2 SGCG ACHE NAV2 IGF1 AGL TAGLN BIN1 PC AGRN HDAC5 SVIL HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING NHERF1 IGFBP5 HEL-S-51e HMGCR PLK1 GLA CTSC ELOVL6 NIBAN1 TES INSIG1 HEL-S-162eP GSK3B CYP51A1 UBE2D3 SCD CD9 DHCR7 SLA HEL-S-125m TBK1 MAP2K3 ACTR3 ACTR2 IFI30 IDI1 IMMT IFRD1 PFKL FDXR ADIPOR2 USO1 RDH11 ADD3 SQSTM1 YKT6 DHCR24 CXCR4 PIK3R3 DAPP1 M6PR PSMG1 HEL-S-99n RRP9 DDIT3 ACACA DDIT4 ATP2A2 TRIB3 NUPR1 TFRC CFP HMGCS1 ELOVL5 AURKA SCAP2 SSR1 RIT1 DDX39A EDEM1 ASNS MTHFD2 NFKBIB ERO1A NUP205 ENO1 HEL-S-89n SERP1 BCAT1 SEC11A PLOD2 PITPNB PSAT1 PSPH NAMPT FADS1 ACSL3 SYTL2 MTHFD2L AF1Q BTG2 FKBP2 CDKN1A PSMD12 EBP PSMD13 RPN1 CORO1A ATP6V1D STC1 HEL-S-94n SLC7A11 HEL-S-66p AK4 SDF2L1 HSPA4 PNO1 BHLHB2 EIF2S2 HEL-S-283 CCT6A DHFR COPS5 EPRS1 TUBG1 ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 CANX EEF1E1 HEL-S-133P MCM2 RAB1A PNP NUFIP1 TOMM40 UNG HSPD1 GGA2 ABCF2 GCLC CYB5B P4HA1 NFYC PDAP1 UFM1 PSMC6 POLR3G PPP1R15A HMBS SLC2A3 HEL-75 RRM2 VLDLR ETF1 HK2 HEL-S-69p RPA1 SLC1A4 ME1 SC5D XBP1 HEL-S-68p HEL-S-26 ACLY NFIL3 CCNG1 LDLR HEL-S-87p GLRX EGLN3 SQLE FGL2 TUBA4A HEL-S-49 TMEM97 NMT1 PSMC4 CTH TM7SF2 SLC7A5 FADS2 STARD4 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE HSPB8 NHERF1 ETFB AMFR KRT13 DHRS2 KLK10 SEMA3B KRT19 GINS2 CHPT1 GLA FDFT1 FRK TJP3 NCOR2 FABP5 CD9 DHCR7 PTGER3 TOP2A HEL-76 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 IL17RB CDC20 ELOVL5 HSPA4L TNNC1 UGDH HEL-S-29 FLNB SFN FARP1 RNASEH2A ST14 PLK4 CCND1 MDK ZFP36 KIF20A FKBP4 GIG8 IGFBP4 IL6ST HR RAB31 CELSR2 RAPGEFL1 SOX3 BTG3 SORD RPS6KA2 MYB DCXR CCN5 FOS CISH ISG20 MAPK13 NPY1R OVOL2 SULT2B1 OLFM1 NAB2 CXCL14 SCNN1A TRIM29 PPIF UNC13B PGR METTL3 NBL1 CACNA2D2 SLC27A2 PRLR PTGES PCP4 FKBP5 PKP3 SLC26A2 TFPI2 LLGL2 HEL-S-10 IGSF1 ARL3 PLAC1 ABHD2 HOMER2 XRCC3 TOB1 CYP4F11 CXCL12 TH GJB3 DUSP2 SLC1A4 DLG5 SCARB1 GPER PERP NMU CALCR PLXNB1 FGFR3 ALDH3B1 SERPINA3 SGK1 BAG1 MOCS2 TFAP2C ST6GALNAC2 XBP1 HEL-S-116 OPN3 SNX10 SLC2A8 WFS1 IMPA2 SIAH2 TPSAB1 ABCA3 JAK1 KLF4 LAMC2 CHST8 TPD52L1 EMP2 LSR KCNK5b AREG DNAJC1 BCL2 GAL TFF3 JDP1 HEL110 SLC29A1 ASCL1 RET TM4SF13 ASS1 CLIC3 KLK11 NXT1 BATF PRSS23 AFF1 CYP26B1 S100A9 ANXA9 DYNLT3 ITPK1 MYOF STIL PLAAT3 CDC6 TFF1 FOXC1 SLC24A3 TMPRSS3 TPBG CD44 PAPSS2 TIAM1 PDLIM3 RBBP8 SERPINA1 SLC7A5 EEIG1 MICB CA12 PTPN6 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION GLUD1 RHOT2 OGDH ETFB CYCS MRPS15 AIFM1 SLC25A3 MRPS11 MRPS12 ETFA DLAT TCIRG1 MRPL34 COX7C COX8A MRPL35 OPA1 TIMM17A UQCRFS1 TOMM70 ATP6V0B MRPS22 NDUFC2 NDUFS3 NDUFC1 BDH2 NDUFS8 NDUFS6 NDUFS4 NDUFB7 NDUFS1 SLC25A12 SLC25A5 ATP6V0C UQCR11 FXN SLC25A11 UQCR10 SLC25A4 SLC25A6 NDUFB8 CPT1A NDUFB6 NDUFB5 NDUFB4 TIMM9 NDUFB3 SDHD NDUFB2 SDHA TIMM13 NDUFB1 MRPS30 TIMM10 VDAC3 HEL-S-123m NDUFA5 COX5A SUCLG1 MFN2 SLC25A20 MST065 NDUFA9 IMMT TIMM8B NDUFA7 NQO2 PPM2C NDUFA6 ATP5PB MTX2 ZNF183 NDUFAB1 NDUFA3 ATP5PO DECR1 NDUFA2 PDHA1 ATP5F1D ATP5F1E ACO2 ACADVL HCCS ISCU IDH3B ACADM RETSAT HADHB FH ECHS1 HSD17B10 COX17 LRPPRC SURF1 HEL-S-281 SUCLA2 SDHC ATP6V1D ISCA1 ATP5G1 GOT2 HEL-S-133P POLR2F GPX4 HEL-S-32 HTRA2 COX6A1 PHYH HEL-S-26 PDK4 SDHB POR BAX UQCRC1 MTRR FDX1 PHB2 MGST3 DLD HEL-S-271 MTRF1 MPC1 MRPL15 PMPCA PRDX3 ATP6V1E1 PDHX ATP6V1G1 GRPEL1 ATP6V0E1 ATP1B1 COX6B1 NNT OXA1L COX7A2L CYC1 COXFA4 UQCRC2 UQCRB ABCB7 ATP5MC2 ATP5MC3 MDH2 ATP5J COX7A2 ATP5H UQCRH ALAS1 ACAT1 MRPL11 CS TIMM50 CYB5R3 RHOT1 COX11 UQCRQ NDUFV2 ATP5MG ATP5MF ATP6V1C1 COX10 COX7B ATP5ME ATP6V1F ACADSB HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE ZMIZ1 FADS1 ACSL3 KRT19 HMGCR INPP4B ANKH INSIG1 H1-0 SCD SORD DNAJB9 PTPN21 AKAP12 B2M SMS CCND3 IDI1 GNAI3 ARID5B B4GALT1 HEL-75 FKBP5 SLC26A2 LMAN1 ABHD2 HOMER2 SRP19 STEAP4 NGLY1 DHCR24 DBI CDC14B HERC3 PGM3 NKX3-1 PIAS1 ALDH1A3 SGK1 TPD52 MAF SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A UBE2J1 PTK2B RAB4A UBE2I TMEM50A XRCC5 APPBP2 VAPA HMGCS1 CENPN ITGAV ELOVL5 GPD1L ACTN1 HPGD TMEPAI MERTK CDK6 ADRM1 SPDEF PA2G4 CCND1 SPCS3 HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP CTSS PRRX1 SEMA3B FCER1G TMEM176B ADAM17 HEL-76 RETN C3AR1 AKAP12 SCG5 SCN1B CMKLR1 SCG3 CCND2 NGF PCSK1N TFPI MAP3K1 CIDEA CXCR4 APOD SNAP91 IL2RG ALDH1A3 DOCK2 CBL CSF2RA PLVAP TNFRSF1B SPON1 F13A1 IKZF1 FGF9 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC CLEC4A SLPI ERO1A MALL ADAM8 TRIB2 ZNF277 TPH1 MAP4K1 ABCB1 TOR1AIP2 LY96 TSPAN7 PLEK2 KCNN4 MMP9 TSPAN1 JUP PRELID3B FUCA1 SOX9 CBX8 IGF2 G0S2 AMMECR1 PPBP LIF NR0B2 IL10RA GNG11 GADD45G CCSER2 STRN AVL9 PLAT BMP2 PIGR CSF2 SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 TEM5 EREG CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 LAT2 GIG8 MMP11 ANKH ZNF639 ALDH1A2 TLR8 LCP1 SDCCAG8 TRIB1 PECAM1 USP12 USH1C HOXD11 IL1RL2 RELN GPNMB CBR4 IL33 PTCD2 GALNT3 ENG H2BC3 TMEM176A GABRA3 NR1H4 LAPTM5 VWA5A MPZL2 NAP1L2 WNT7A TMEM158 CFHR2 YRDC SPRY2 ADGRL4 IL7R HBEGF PPP1R15A EMP1 RGS16 IL1B PCP4 INHBA BIRC3 GYPC SATB1 MAFB TRAF1 SERPINA3 TNFAIP3 PTGS2 KLF4 RBP4 SPARCL1 TM4SF13 ANGPTL4 CCL20 CFB ITGA2 CFH HSD11B1 PLAUR GLRX F2RL1 opn IRF8 NRP1 CROT ARG1 PSMB8 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM NPC1 KLF1 ABCA2 ATXN1 HEL-S-182mP HEL-S-53e PRDX5 MLYCD SLC67A1 AQP9 ACSL1 ACSL5 IDI1 FDXR LCK DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 NR1H4 PECR SLC23A2 SLC35B2 SLC23A1 CYP46A1 SULT2B1 HEL111 NR3C2 PEX26 LONP2 NUDT12 ABCG8 DIO1 PIPOX SLC27A2 CH25H OPTN GNPAT SOAT2 RBP1 PEX11G ABCG4 SLC27A5 HAO1 ABCA5 ABCA6 ABCA4 RXRA ISOC1 ABCA9 ABCA8 BMP6 SULT1B1 AMACR PXMP2 SLCO1A2 LIPE ABCD3 TFCP2L1 LOC51064 PHYH ABCD1 CYP7B1 HEL-S-26 PEX7 ABCA3 PEX6 EFHC1 AGXT PAOX AKR1D1 HSD17B6 CYP7A1 CYP27A1 SLC29A1 GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 GCLM NR1i2 BBOX1 PEX12 CYP8B1 ALDH9A1 PEX13 NEDD4 ALDH8A1 EPHX2 ABCD2 CROT HEL-S-44 FADS2 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 SET GLO1 CSTF2 PCBP1 NOP16 SLC25A3 CDC45 CBX3 MRPL23 SFRS3 KARS1 LSM2 SRPK1 MYC AIMP2 LSM7 UBA2 RNPS1 HNRNPC HSP90AB1 TOMM70 RPLP0 YWHAQ C1QBP DHX15 HNRPA3 MRPL9 PTGES3 NCBP1 VBP1 PABPC4 CAD GNL3 AP3S1 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 RPS2 CCT7 VDAC3 CCT4 COX5A RRM1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 IFRD1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 NDUFAB1 TARDBP EIF3B EIF4A1 RRP9 EIF4E NHP2 CDC20 RFC4 CDK4 CDK2 IARS NOLC1 ORC2 APEX1 PA2G4 EIF2S1 NPM1 XPOT EIF3J HNRNPD ABCE1 EIF3D HEL-S-97n NCBP2 EIF2S2 COPS5 EPRS1 MCM5 PSMA4 GOT2 CANX MCM6 HEL-S-133P MCM2 TYMS HSPD1 TRA2B POLD2 USP1 PSMC6 PCNA H2AZ1 NOP56 RANBP1 DUT ETF1 HEL-S-69p IMPDH2 DEK RPL18 HEL-S-68p MCM7 RAN MAD2L1 SNRPD1 HEL2 SMARCC1 PHB2 PRDX3 PSMA2 HEL-S-276 RPL34 HNRNPR PWP1 RPL6 UBE2L3 CYC1 EEF1B2 FBL PSMD7 SNRPD2 TRIM28 RUVBL2 PSMD3 PSMD1 SNRPD3 TXNL4A PSMB2 RPS10 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 PSMC4 UBE2E1 CCNA2 TUFM CLNS1A SNRPG ERH TFDP1 SRSF7 HDAC2 SNRPA HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN KRT13 EGF PTGFR SERPINB2 GP1BA PKP1 ZC2HC1C ATP6V1B1 EDN2 MEFV PNMT CLSTN3 ARHGDIG IRS4 PARK2 NUDT11 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 PP1187 CD40LG PDK2 CPA2 KRT4 SELENOP ENTPD7 KRT1 UGT2B17 CDKAL1 KRT5 RYR1 SOX10 EDAR SCN10A CLPS HEL-S-79 KCNQ2 MSH5 FGF22 SIDT1 CALCB CPB1 KCNE2 SHOX2 CACNA1F MACROH2A2 DCC SLC5A5 HSD11B2 FGGY KCNMB1 KLK8 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B DTNB AMBN HTR1D HTR1B FGF16 HEL-S-75 AKR1B10 IL5 TNNI3 TG GDNF STAG3 ARPP-21 MYH7 CYP11B2 KLHDC8A PCDHB1 TLX1 CHRNG CD207 IFNG ZBTB16 CPEB3 ZFP112 CACNG1 GPR19 BARD1 RYR2 TENM2 MAST3 SERPINA10 OXT SLC6A3 LFNG CCR8 INSL5 CD80 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 LYPD3 SPHK2 FSHB IL12B NGB COPZ2 SKIL BTG2 PAX3 TEX15 HEL-S-20 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT TFF2 CLDN16 ITGB1BP2 CDH16 IGFBP2 GPRC5C SLC29A3 SPRR3 SNN ITIH3 SMPX NPY4R CELSR2 PLAG1 ALOX12B GTF3C5 CCDC106 ABCB11 NR1A2 P2RY4 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 RSAD2 MYO15A SCGB1A1 YPEL1 ASB7 MAGIX PDCD1 RGS11 BRDT PAX4 ABCG4 HNF1A EDN1 FGFR3 SGK1 TFCP2L1 COQ8A IDUA SYNPO CNTFR TENT5C MX1 HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME FADS1 DHRS3 BCL10 FDPS ATXN1 HRAS TOP2A HEL-S-53e PABPC1 PRDX5 MLYCD ABCC5 SLC25A4 ACOT8 ACSL1 ACSL5 PBR SLC23A2 SLC35B2 SULT2B1 HEL111 IDI1 CNBP LONP2 SCGB1A1 DIO1 VPS4B CADM1 SLC27A2 GNPAT DKFZp667O1614 RDH11 STS ABCC8 HAO2 NUDT19 PEX2 NR3A2 SLC25A17 PEX14 PEX5 ERCC1 CRABP2 DHCR24 SEMA3C CTBP1 ISOC1 ABCB4 CRABP1 PEX11B CACNA1B ABCB9 CLN8 ABCD3 FIS1 SIAH1 LOC51064 UGT2B17 CDK7 ABCD1 DLG4 HEL-S-26 FABP6 ALB PEX6 RETSAT RXRG ELOVL5 HSD3B7 SMARCC1 FACL4 HSD11B2 NR1i2 MSH2 ACOX1 EHHADH ALDH9A1 PEX13 HSD17B4 CLN6 HSD17B11 ABCB1 MVP HMGCL EPHX2 ABCD2 HEL-S-44 CRAT HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 NOP16 CBX3 RRP9 MYC AIMP2 MYBBP1A NIP7 PLK1 NOP2 PPAN NOC4L RABEPK WDR43 RCL1 TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 IMP4 GNL3 TFB2M PPRC1 SORD BYSL LAS1L CDK4 GRWD1 MCM5 NDUFAF4 MRTO4 SRM MPHOSPH10 DCTPP1 UNG HSPD1 SLC19A1 NOLC1 NOP56 TMEM97 EXOSC5 PLK4 HK2 PA2G4 NPM1 DUSP2 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING RBX1 PSENEN PSEN2 NOTCH3 TCF7L2 NR1C2 MAML2 FBXW11 FZD7 DTX1 DTX2 PRKCA DTX4 ST3GAL6 SKP1 FZD1 NOTCH1 HES1 KAT2A NOTCH2 SAP30 LFNG FZD5 CCND1 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY ATOX1 LAMTOR5 PRNP SELS HEL-S-97n JUNB HEL-S-2a TXN NQO1 GCLM NDUFB4 GLRX GCLC ABCC1 GPX4 GPX3 HEL-S-112 SRXN1 MGST1 MPO PTPA HHEX HEL-S-44 SBNO2 NDUFA6 HEL-75 MBP CDKN2D EGLN2 TXNRD2 GLRX2 OXSR1 IPCEF1 SCAF4 PFKP MSRA FES ERCC2 HEL-S-128m FTL HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP GLS HTR7 BCL2L11 TMBIM6 STARD3 MSX1 DKFZp686L0365 HLA-F MAPK8IP2 MRPL23 CDC34 POLG2 PRPF3 SELENOW TYRO3 NPTXR CHRNA5 CYB5R1 APOM NKX2-5 NPTX2 KLHDC3 GGH CHKA RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 ONECUT1 CLTB SPR HEL-76 CDO1 UROD HYAL2 SLC25A4 NUP58 TGFBRAP1 DDX21 WIZ CLCN2 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 PLCL1 CDC5L CCK GRINA CCND3 MAOA POLE3 SQSTM1 AP2S1 YKT6 HSPA2 CYP1A1 TFRC ATF3 TARS1 SHOX2 RFC4 TACR3 RRAD PARP2 CCNE1 ASNS CDK2 HMOX1 ABCB1 EPHX1 CEBPG BMP2 FEN1 CDKN1C ENO2 FKBP4 FURIN H2AX BTG2 BTG1 JUNB RPN1 TCHH COL2A1 CNP HEL-S-94n IL6ST IGFBP2 AQP3 PPT1 BTG3 IRF-1 NFKBIA CASP3 FOS CYB5B PDAP1 GPX3 POLR2H OLFM1 hEMMPRIN PPIF CXCL2 IL6 SLC6A8 BAK1 CDKN2B DLG4 DGAT1 C4BPB GAL SLC6A12 RET SULT1A1 HEL-S-87p GRPEL1 FOSB RHOB MMP14 LYN AMD1 TUBA4A ALAS1 PDLIM3 ATP6V1C1 ATP6V1F HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING IGF1R DHRS3 MYC PTCH1 RORA ENO3 HEL-76 PLSCR1 AHR GABARAPL1 CD81 SERPINC1 CYFIP1 ANXA4 GUCY1B1 CCND3 IKZF2 CCND2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 ENPP1 SLC39A8 TNFRSF4 WLS GPR65 PRKCH S100A1 SWAP70 FLT3LG ADAM19 SYNGR2 TWSG1 MAPKAPK2 GPR83 PRNP AGER SOCS2 SELL IL1R2 CD79B PENK MAP6 PLPP1 SNX9 ICOS POU2F1 IL3RA HOPX LTB DRC1 TNFRSF21 CDC42SE2 PHTF2 SHE CTSZ PTH1R ITGAE GLIPR2 NCS1 IL10 NFKBIZ SH3BGRL2 CTLA4 SIAT4C IL2RA CCR4 TNFRSF1B BATF3 TNFRSF18 CKAP4 SERPINB6 CDCP1 ARL4A PTRH2 CCNE1 COL6A1 CD48 SOCS1 TLR7 ITGA6 PTGER2 IRF6 SMPDL3A PLEC AHNAK CST7 COCH IL1RL1 PLAGL1 ABCB1 LRRC8C DCPS IL13 PRAF2 SPRY4 HUWE1 MYO1E ARHH TTC39B SYT11 SNX14 ETFBKMT F2RL2 EEF1AKMT1 LIF IL10RA IFITM3 CD83 BMP2 P2RX4 CSF2 MYO1C CSF1 IL2RB TNFSF10 RRAGD IL18R1 CDKN1C MXD1 BMPR2 FURIN MAP3K8 ETV4 DENND5A PHLDA1 HIPK2 APLP1 BHLHB2 IGF2R HEL-S-66 UMPS BCL2L1 TNFRSF9 CASP3 PNP CISH P4HA1 GPX4 IFNGR1 EMP1 SLC2A3 RGS16 GADD45B HK2 TRAF1 AMACR GATA1 XBP1 SELP NOP2 NFIL3 BCL2 ADFP PIM1 ITGAV BATF KLF6 IRF4 opn IRF8 RHOB NRP1 CDC6 FGL2 UCK2 CD44 GBP4 TIAM1 MUC1 MAFF LRIG1 HEL-S-21 NT5E HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION CTSO HNF4A CTSH OLR1 SERPINB2 GP1BA F11 F3 CD9 THBD F8 MMP15 RAC1 C1QA C1S SERPINC1 TMPRSS6 PLG CFD FYN F10 S100A1 HEL-S-62p KLF7 APOC1 KLKB1 ISCU A2M PF4 KLK8 MEP1A SIRT2 MBL2 CAPN5 MMP9 F2RL2 GDA MASP2 CPB2 SPARC PEF1 CFI PROZ PLAT GNG12 CLU TF PROC F13B ARF4 C8A DUSP14 C8G CTSK FGA FURIN MMP7 F9 DCT COMP MMP10 HEL-S-52 VWF CRIP2 LEFTY2 CPN1 P2RY1 MMP11 SH2B2 HEL-S-41 APOC3 APOC2 MSRB2 PECAM1 USP11 CASP9 HTRA1 ANXA1 F2 TFPI2 BMP1 FBN1 PROS1 ITGB3 LAMP2 TIMP3 ANG TIMP1 PRSS23 ADAM9 SERPING1 CFB ITGA2 CFH MMP2 MMP3 DPP4 C9 S100A13 MMP14 HRG GP9 GNB2 MAFF THBS1 SERPINA1 CPQ PLEK S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA PIK3CA ITGA6 PLEC COL17A1 LAMA5 HEL-S-93 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 DKFZp686L0365 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 HEL-S-93 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 HNRNPR ENO1 ANTXR1 CRKL GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RFC1 RIPK2 ANXA4 UBE4B TRAF2 TRAF1 LCK TRAF3 CSNK2B TCP1 BTK PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 hCG_2014051 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL hCG_2014051 SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF RAF1 CRK RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KB1 TH PTK2B FYN GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH PTCH1 HHIP PTCH2 DYRK1A IHH KIF7 MED6 GLI3 KIF27 MED23 MED12 CDK8 SHH CCNB1 SMO ADRBK1 SUFU BOC SAP18 GAS1 MED1 HEL2 DKFZp686L0365 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 GIG8 RBL1 PSMD4 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma IRF-1 MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 IRS1 PRKCE RPS6 M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF NOTCH%IOB%NOTCH Notch TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C DKFZp686L0365 ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF BRCA1 XPO4 SUMO1 HNF4A MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha GLG1 BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF HEL-S-93 COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA PIN1 TCF4 GSK3B GSK3A DIXDC1 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 DKFZp686L0365 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY TP53INP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 opn SERPINB5 DDB2 RNF144B VCAN RRM2B HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 EGFR PERP PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 TOP3A XRCC3 RPA1 FANCA ATM MRE11A HUS1 FANCB FANCE PALB2 FANCG FANCF RAD50 FANCD2 UBE2T RAD17 BRCA1 RAD1 FAN1 ATR CENPS RAD9A TOPBP1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY PPP3CC CAPNS2 CALM1 MEF2D HDAC1 HDAC2 PRKCB EP300 NFATC2 PRKCA NFATC1 CABIN1 PPP3CA BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 MED1 RXRA LPL PPARG PPARGC1A EP300 CREBBP PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A YAP1 HEL2 ZFYVE9 PML CAMK2A PPP2R2A CTGF PPP2CA PARD6A SHC1 DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 DKFZp686L0365 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 RPS6KB1 ITCH ZFYVE16 ARHA BAMBI STRAP GRB2 SOS1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY CXCL12 ADAM12 FGFR1 RAC1 ARHA ITGB1 TNFRSF13B SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 FGF6 SDCBP MDK CCL5 ACTN1 FZD7 PRKCA F2 NUDT16L1 MMP9 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 ADCY1 LPAR4 ADCY8 ADCY6 ADCY5 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY NECTIN2 NECTIN1 PIK3CA FARP2 SRC ITGB3 PTPRM IQGAP1 F11R PIK3R1 CLDN1 VAV2 CDC42 AFDN RAP1A CTNNA1 RAPGEF1 ITGAV PIP5K1C RAC1 TLN1 CRK NECTIN3 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 DES INCENP NCL BIRC5 TACC1 KIF20A PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA ITGB1 KNS2 RALA CLTC BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY TGFBR1 TGFBR2 MAP3K7IP1 ZFYVE9 APC MAP3K7 SKIL SMAD2 SMAD4 EP300 MAP2K1 TGFB1 MAPK3 CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 COL17A1 RAC1 LAMA5 HEL-S-93 ITGB4 LAMA4 LAMC2 MST1R LAMC1 RXRB ERBB3 RPS6KB1 YWHAQ PIK3CA ERBB2 HEL-S-1 HRAS RXRG ITGB1 YWHAG GRB2 LAMB3 EGF LAMA1 LAMB2 LAMA3 LAMB1 IL1A PMP22 CD9 PRKCA EGFR BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 TF SYNJ1 SRC SHC1 PIK3R1 CDC42 RAP1A MAP2K1 HEL-S-31 MAPK3 RAC1 CRK PIK3CA HRAS GRB2 GRB7 ROCK1 PXN ITSN1 WASL EFNA5 PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY AXIN1 CDKN2A KAT2A MAX PML GSK3B MYC TAF12 FBXW7 PPP2CA TAF10 ACTL6A TRRAP PPP2R5A SUPT7L KAT5 TAF9 RUVBL2 RUVBL1 PIN1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADRB2 ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 GIG8 HNF4A CA9 IGFBP1 EDN1 FOS HEL-S-68p ADFP NPM1 TFF3 ABCG2 ENG HEL-S-87p FECH BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 VEGFA PFKL COPS5 LEP JUN SP1 TERT SMAD4 CXCR4 ABCB1 EP300 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA CSNK2A1 LCK SYK CSNK2A2 MAPK14 IKBKB NFKBIA CSNK2B SRC REL PIK3R1 RELA DKFZp686L0365 BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY LYN SELP ACTA1 EPHA4 FYN EPHB1 ITGB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG BTC NRG3 NRG4 ERBB4 HBEGF EGFR TGFA PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY ADCY9 GNAL EDNRB MAPK1 PRKCE ADCY3 JUN ADCY1 ADCY8 MAPK14 ADCY6 ADCY5 SRC CDC42 MAP2K1 MAPK3 RAC1 GNAZ CRK GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 KPG_011 PTK2B TRPC6 MAP2K2 ARHA HRAS EDN2 PRKCH GNAO1 SLC9A3 EDN1 PLCB3 FOS COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB PRKCA BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY HEL-75 NFKB1 HEL-S-64p CXCL8 HEL-S-44 RELA XDH GPX1 TNF BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY IL4 IL3 IL6 IL2 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 TNF IL10 IFNA1 IFNB1 IL15 IL13 IL18 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAPK8 NFKB1 MAP2K3 JUN ATF1 MAP4K2 MAP2K4 MAPK14 MAP3K1 IKBKB CHUK NFKBIA CRADD TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 RELA MAP2K6 TNF PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY CDKN2A COPS5 EGLN2 HIF3A HIF1A RBX1 OS9 ARD1A EGLN1 VHL EGLN3 ELOC HIF1AN PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PAK1 PLD2 MAPK1 MAPK14 NCK1 AGTR1 SHC1 PIK3R1 FYN RELA MAPK3 RAC1 CRK FOXO1 GRB14 PTPN11 ANGPT4 MAPK8 STAT5B ANGPT2 NFKB1 ANGPT1 BMX RPS6KB1 ELF1 PIK3CA ELF2 FES ITGB1 MMP2 GRB2 CDKN1A PLG FGF2 TNF GRB7 PXN F2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 YWHAQ GADD45A ATM CDKN2D PRKDC PLK1 MYT1 CDC25B WEE1 CDC34 CDKN1A CHEK2 RPS6KA1 BRCA1 MDM2 ATR CHEK1 EP300 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY IL3 STAT5B HRAS GRB2 SOS1 FOS RAF1 SHC1 CSF2RB IL3RA PTPN6 MAP2K1 MAPK3 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RIN1 SOS2 NRAS RRAS PRKCE HRAS GRB2 SOS1 RASGRF2 PRKCZ RASGRF1 DAB2IP RASAL1 PRKCB RASGRP4 RASGRP3 PRKCA SYNGAP1 RASA4 RASA2 NF1 PLCE1 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY STAT5B IL2 MAPK8 JUN CSNK2A1 LCK SYK IL2RA IL2RB HRAS GRB2 SOS1 FOS RAF1 SHC1 IL2RG MAP2K1 MAPK3 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY CHRNA1 DOCK7 PIK3CD NRAS PIK3R3 PIK3R2 MAPK9 MAPK1 CHRNE JUN BAD STAT3 NFATC4 RNF41 MAPK10 NF2 SRC SHC1 PIK3R1 NRG1 CDC42 NRG2 MAP2K1 MAPK3 RAC1 PTPN11 MAPK8 MTOR ERBB3 PIK3CA ERBB2 MAP2K2 HRAS GRB2 SOS1 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY CCNB1 AKAP8 PPP2CA CDC2 DDX5 PRKACG PRKAG1 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY IL4 CCNA2 SP1 MYC PRF1 CCND2 SHC1 FOXP3 PIK3R1 CDK6 IL2RG TNFSF6 LTA JAK3 JAK1 PTPN11 GAB2 STAT5B IL2 ELF1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 BCL2L1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY IFNG PIK3CA JUN CSNK2A1 GRB2 SOS1 FOS SHC1 PIK3R1 PDGFRA CAV3 SHB CRKL RAPGEF1 SHF ITGAV PLCG1 CRK JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY LRP8 GRIN2B DAB1 MAPK8 RELN CDK5 MAP1B NCK2 PIK3CA ARHGEF2 MAP3K11 CDK5R1 PAFAH1B1 ITGB1 GSK3B PIK3R1 FYN RAP1A CRKL RAPGEF1 LRPAP1 VLDLR CBL BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 RPS6KA5 MAP2K4 MAPK14 MAP3K1 MAX TRADD MYC TRAF2 SHC1 RIPK1 MAP3K7 CDC42 MAP2K6 TGFB1 RAC1 TGFBR1 HRAS ATF2 HSPB2 GRB2 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 CDK4 CDK2 ATM CHEK1 MYT1 CDC25B WEE1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY PAK1 MAPK1 JUN STAT3 ACTA1 PIK3R1 RAP1A CRKL RAPGEF1 MAP2K1 MAPK3 PTEN CRK PTPN11 MAPK8 PTK2B PIK3CA MAP2K2 HRAS ITGB1 GRB2 SOS1 FOS RAF1 MAP4K1 HGF DOCK1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY AGTR1 REN AGTR2 ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 TSG101 CD3G CD3E CDC2 CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PRKAR1B PRKAR1A PRKACG PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY PAK1 MAP3K7IP1 MAP2K3 LCK MAP2K4 MAPK14 BLK YES1 RALB SRC DUSP8 LYN DUSP16 c-fgr MAPK11 DUSP10 TRAF6 FYN RIPK1 MAP3K12 CDC42 MAP2K6 RAC1 RALA BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY IL4 IL2 MAPK8 NFKB1 IFNG JUN ATF2 MAPK14 MAP3K1 IKBKB CHUK NFKBIA MAP3K5 TRAF2 TNLG5A TNFRSF9 RELA BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY ACTA1 CDC42 WASF1 RAC1 WASL PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 UCP2 TFRC NKX2-1 ACADM PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 PDX1 HNF1A HNF4A CPT1C FOXA1 G6PC1 IGFBP1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP F2 NF1 PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 CCL17 SOCS5 EGR2 HMGA1 PARP14 COL1A1 CD40LG MAPK14 CCL26 SP1 SELP SHC1 PIK3R1 BCL6 IL2RG LTA MYB JAK3 JAK1 CBL MTOR RPS6KB1 PIK3CA GRB2 COL1A2 BCL2L1 IL10 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY CTNND1 FGFR1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CAMK2G PIK3R1 HEL-S-61 PTPN1 CDC42 JUP GAP43 FER CTNNA1 MYL2 DAGLB MAPRE1 PIP5K1C PLCG1 RAC1 AXIN1 PTPN11 MAPK8 PIK3CA ARHA ROCK1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EPO HEL-S-133P CREB1 VEGFA COPS5 JUN HIF1A EP300 ASPH EDN1 VHL PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY CREB1 ITGA4 PIK3CA MAPK1 ITGA2 COL1A1 MAP2K4 ITGA1 MAPK14 ITGB1 GRB2 SOS1 COL1A2 MAPK11 RPS6KA1 SHC1 PIK3R1 MAPK3 FLT4 VEGFC CRK VEGFD BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY APP PPP2CA CAPNS2 CDK5 CDK5R1 GSK3B PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 ROR2 WNT1 WNT3 CTHRC1 DKK1 FZD7 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY MAPK1 MAP2K2 ADCY1 HRAS c-fgr RAF1 PLCB1 KCNA1 KCNA2 KCNA3 ADRBK1 GNAS MAP2K1 MAPK3 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY GRK5 SNCA TH STUB1 PLD2 HEL-117 MAPK1 CSNK2A1 SYK BAD BLK YES1 SRC LYN c-fgr FYN MAPK3 FKBP1A PTK2B LCK PLCB2 PPP2R5D HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY MAPK8 PDGFA PIK3CA JUN CSNK2A1 STAT3 HRAS MAP2K4 MAP3K1 GRB2 SOS1 FOS STAT1 RAF1 SHC1 PIK3R1 PDGFRA PRKCB MAP2K1 PRKCA PLCG1 MAPK3 JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY NCOA1 MED1 NR1i1 KAT2B SMARCE1 RXRA SMARCD1 SUPT16H SMARCC1 SMARCC2 HDAC1 PRMT1 BAZ1B ARID1A NCOR1 CHAF1A SMARCA4 CARM1 ACTL6A TSC2 EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY ITGAM SELP IL1A SELPLG SELL PECAM1 ICAM2 IFNG CXCL8 TNF CSF3 PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY THY1 IL6 BLK YES1 SRC ITGAM CTGF LYN SELPLG c-fgr SELP FYN PLAT HMGB1 PRKCZ AGER RAP1A APOB JAM2 JAM3 PLAUR MYH2 TLN1 LPA MST1R NFKB1 LCK ARHA MMP2 PLG TNF ROCK1 MMP9 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY KITLG IL3 KIT PIK3CA MAPK1 BAD ADCY1 BCL2 RPS6KA1 BAX CSF2RB PIK3R1 IL3RA PRKAR1B PRKAR1A MAPK3 IGF1 PRKACG IGF1R BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY SELL SELE PECAM1 CD44 ITGA4 ITGB1 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 MAP2K1 CREBBP LAMA4 CDKN2A GSK3A CDC2 ONECUT1 FOXM1 CENPA CENPB CKS1B CDK2 CCNB2 AURKB CCND1 NEK2 MMP2 PLK1 NFATC3 H2BC1 FOS ETV5 CDC25B CENPF RB1 GAS1 CHEK2 CDK4 EP300 BIRC5 TGFA BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 POLR1A CDKN2A POLR1C POLR1D TWIST1 PIK3R1 TBX2 MDM2 PIK3CA RAC1 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK YES1 SRC LYN c-fgr MAPK11 FYN PRKCZ DKFZp686L0365 RAC1 GNA14 SELE GNA15 GNA11 LCK ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PIK3R5 GNA13 GNG2 ADRBK1 TBXA2R PRKCB ROCK1 PTGDR PTGIR PRKCA NHERF1 EGFR VCAM1 RAB11A PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 PIK3R3 WWOX PIK3R2 CBFA2T3 MAPK1 PRLR ADAM17 DLG4 NEDD4 YAP1 NCOR1 SHC1 PIK3R1 FYN NRG1 NRG2 MDM2 EREG BTC NRG3 NRG4 ERBB4 MAPK3 HBEGF WWP1 GRIN2B STAT5B ITCH PIK3CA ERBB2 GRB2 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY CREB1 RPS6KA5 PIK3CA MAPK1 ADCY1 HRAS MAPK14 GRB2 SOS1 RPS6KA1 PIK3R1 PRKCB PRKAR1B PRKCA PRKAR1A MAPK3 RAC1 PRKACG PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY GNB1 PLD2 IL8RB PPP2R1A VASP ELMO1 DOCK2 LYN RAB5A PPP2CA c-fgr RAB7A DKFZp686L0365 PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 GNG2 PRKCB PRKCA RAB11A BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 DNCL1 NDEL1 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY EPO STAT5B MAPK8 JUN CSNK2A1 HRAS GRB2 SOS1 FOS RAF1 SHC1 PTPN6 EPOR MAP2K1 PLCG1 MAPK3 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY NRG2 ADAM17 NRG3 PRKCB PSEN1 ERBB4 PRKCA BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ITGB3 CAPNS2 ACTA1 ARHA ACTN2 ACTN1 ITGB1 EZR RAC1 TLN1 SPTAN1 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY PIK3CD PIK3R3 PIK3R2 MAPK9 JUN BAD MAP2K4 NCK1 MAPK10 PARD6A PIK3R1 FYN PRKCZ DKFZp686L0365 PLCG1 RAC1 PRKCI CD2AP TJP1 NPHS1 NPHS2 MAPK8 F2RL2 NCK2 PIK3CA TRPC6 GRB2 WASL BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY THY1 CD3G PTPRC CD3E CD3D CD2 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY MAP3K1 CRADD TRADD TRAF2 PRF1 TNFRSF1A ACTA1 BAX CASP2 RIPK1 SPTAN1 APP PIDD1 HEL113 CASP10 CASP6 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 BCL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 LIMK1 KRT18 MADD GAS2 CYCS TNF BIRC2 BIRC3 APAF1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY IQGAP3 HEL-S-15 HEL-S-47e PAK1 HES5 PAK4 SEPTIN2 LIMK2 PRKCE MAPK1 TNK2 MAP2K3 BRAF ARPC4 ARPC5 MAP2K4 CDC42BPA MAP3K1 BAIAP2 YES1 ARPC2 APC ARPC3 GSK3B SRC IQGAP1 VAV2 CDC42 MAP2K6 CTNNA1 RASGRF1 MAPK9 EXOC7 JUN MAPK14 PARD6A PIK3R1 PRKCZ MYL2 MAPK3 RAC1 CBL MAPK8 F2RL2 MTOR RPS6KB1 PIK3CA MAP3K11 HRAS ATF2 RAF1 LIMK1 ARPC1B ACTR3 ACTR2 WASL TIAM1 ARHGEF7 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY VEGFA PIK3CA HRAS EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX SHC1 PIK3R1 EIF2S2 SUI1 EIF2S1 ELAVL1 EIF2S3 HIF1A KDR PRKCB EIF2B1 PRKCA PLCG1 FLT4 VHL BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY FOXO1 NFKB1 PIK3CA BAD CASP9 IKBKB CHUK NFKBIA PPP2CA PIK3R1 TNFSF6 IKBKG RELA FOXO4 GHR FOXO3A GH1 PDPK1 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB4A RAB5A RAB6C RAB7A ACTA1 RAB9A RAB27A RAB8A RAB2A RAB1A RAB11A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY FSHB FSHR CREM FHL5 ADCY1 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY PSENEN NCAN SDC3 CASK PTN MC4R SRC POMC APH1B AgRP FYN CXCL8 PSEN1 EGFR PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY PAK1 GADD45A NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA CDC25B HCTP4 OAZ1 FZR1 BRCA1 DLGAP5 PPP2R5D TDRD7 CKAP5 TACC3 AURKAIP1 BIRC5 AJUBA TACC1 RAN ARHGEF7 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY KAT2A TAF12 TAF10 BAX ACTL6A SUPT7L KAT5 E2F3 EIF2S1 RUVBL2 RUVBL1 NBN CREBBP TFRC ENO1 GIG8 NPM1 NCL BIRC5 EIF4A1 BMI1 PEG10 UBTF PIM1 CCNB1 RCC1 HEL-S-133P HEL-S-162eP CAD PMAIP1 NME2 BCAT1 PTMA SHMT1 HMGA1 IREB2 RPL11 CDCA7 MTDH HSPD1 MAX PRDX3 MDIG MYC MYCT1 PDCD10 EIF4E CCND2 HSPA4 HUWE1 KIR3DL1 FOSL1 LIN28B GPAM POLR3D TERT NDUFAF2 SMAD4 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP CDK4 TAF9 EP300 TK1 MMP9 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY IL6ST IL6R IL6 ERBB3 PIK3CA MAPK1 ERBB2 STAT3 HRAS GRB2 SOS1 CARM1 RAF1 SHC1 PIK3R1 EP300 MAP2K1 ERBB4 MAPK3 EGFR GRIP1 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNB1 CDK7 SHH CCNH CDC2 PTCH1 MNAT1 CDC25B BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY AGTR2 CALM1 MAPK8 CDK5 GNA11 KNG1 MAPK1 PTK2B MAP2K2 STAT3 HRAS MAPK14 GRB2 SOS1 STAT1 RAF1 SHC1 FYN PRKCB MAP2K1 PRKCA PLCG1 MAPK3 F2 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY TH CREB1 SFN YWHAQ MAPKAPK3 HEL-S-1 TCF3 MAPK14 HEL2 YWHAG CDC25B HEL-S-102 RAF1 MAPK11 MAPKAPK2 TSC2 HEL-S-93 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY MAP2K3 ADAM17 MAP4K2 IKBKB MAP3K1 CHUK TRADD TRAF2 TNFRSF1A RIPK1 MAP3K7 IKBKG PRKCZ RELA SMPD1 HEL-S-31 PRKCI NFKB1 MAP3K7IP1 NRK CASP8 TNFAIP3 TXN SMPD2 MAP3K5 BAG4 FADD RFFL STAT1 MAP4K3 TRAF1 TNFRSF1B CYLD TNIK MADD SQSTM1 NSMAF TNF BIRC2 BIRC3 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PPP3CC GRIN2B CALM1 GRIN1 DLG4 PRKCB PRKAR1B PRKAR1A PRKCA PRKACG PPP3CA BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY THY1 CD3G PTPRC CD3E CD3D CD2 CD8A PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY APP TGFBR1 FGFR1 TGFBR2 VEGFA LCK BLK YES1 SRC LAMA1 LYN c-fgr FLT1 FYN NRG1 FGF2 SMAD2 PRNP SERPINC1 TGFB1 PLA2G2A CRIPTO GPC1 SLIT2 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY NGFR NGF DPM2 MAPK8 PIK3CA JUN CSNK2A1 HRAS GRB2 SOS1 FOS RAF1 SHC1 PIK3R1 MAP2K1 PLCG1 MAPK3 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNB1 CXCL9 MAPKAP1 PIK3CD NRAS PIK3R3 CXCL13 PIK3R2 CXCR3 MLST8 MAPK1 RICTOR MAP2K3 CXCL10 CXCL11 MAPK14 PF4 SRC MAPK11 PIK3R1 MAP2K6 MAP2K1 MAPK3 GNAZ PDPK1 GNAI3 GNAI1 MTOR PIK3CA MAP2K2 HRAS GNAO1 RAF1 GNG2 CCL11 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY NGF DPM2 SHC1 PIK3R1 PIK3CA PRKCB HRAS NTRK1 PRKCA GRB2 PLCG1 SOS1 BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY CHEK2 PLK3 ATR ATM CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PTPN11 VEGFA PIK3CA MAPK1 NCK1 NRP1 SHC2 NRP2 VEGFB FLT1 PIK3R1 HIF1A PRKCB PRKCA PLCG1 MAPK3 PDPK1 CBL CD2AP BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY PPP3CC CALM1 NFKB1 EGR2 MAP3K1 CHUK NFKBIA MYC VIPR2 VIP RELA NFATC2 PRKAR1B PRKAR1A PLCG1 NFATC1 PRKACG PPP3CA PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY PIM1 NRAS MAPK1 SYK STAT3 IKBKB LYN CSF2 SHC1 PIK3R1 CSF2RA CCL2 CISH OSM IRF8 MAP2K1 MAPK3 PRKACG HEL-S-93 PTPN11 GAB2 STAT5B PIK3CA MAP2K2 HRAS GRB2 SOS1 FOS STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY PLCB1 KCNA1 KCNA2 KCNA3 ADRBK1 NR1C1 ADCY1 GNAS AP2A1 AP2M1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY ADAM12 AGTR2 EDNRA NFKB1 EDNRB JUN ARHA HRAS EDN1 EGF FOS MYC RELA PRKCB PRKCA PLCG1 EGFR PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY MAPK9 PPARG YES1 MAPK10 CAMK2A MAP3K7 PRKCZ CDC42 DKFZp686L0365 NLK DVL1 RAC1 DVL2 DVL3 FLNA SETDB1 FZD2 CSNK1A1 MAPK8 FZD5 DAAM1 MAP3K7IP1 ARHA ROR2 CTHRC1 ROCK1 NFATC2 FZD7 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY CD3G MAPK8 TYK2 CD3E CD3D IFNG STAT4 CXCR3 CCR5 IL12RB1 JUN IL18R1 MAPK14 ETV5 MAP2K6 IL18 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 CDKN1B TFDP1 CDK2 CKS1B NEDD8 UBE2M RBX1 CCNE1 SKP1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY NFKB1 IKBKB CHUK NFKBIA TRADD FADD TNFRSF1A TNFRSF1B TRAF6 RIPK1 IKBKG RELA TNF EP300 CREBBP PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 AGTR1 ARF6 DKFZp686L0365 GNA14 GNA15 GNA11 ITGA2B CYTH2 KIF13B EGF FBXO8 LHCGR USP6 ARAP2 IPCEF1 GULP1 EFNA1 HGF ACAP2 PXN EPHA2 EGFR PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY FAM120B RARA RARB NCOA1 MED1 NR1i1 RXRB RXRA RPS6KB1 PPARG BCL2 RXRG ABCA1 THRA NR1H2 NR1C1 TNF NR1H4 NR1H3 TGFB1 NR1C2 NR1B3 NR1A2 NCOR2 PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY RIPK2 UBE2D3 NFKB1 BCL10 NOD2 ERC1 ATM TNFAIP3 IKBKB CHUK NFKBIA TNFRSF1A CYLD TRAF6 IKBKG RELA TNF BIRC2 RAN PRKCA PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY ERC1 HEL-S-71 JUN IL1RN IRAK1 TICAM2 IKBKB IL1R1 CHUK IL1R2 IRAK3 IRAK4 IL1B UBE2V1 MYD88 PIK3R1 MAP3K7 TRAF6 IKBKG PRKCZ RELA MAP2K6 PRKCI MAPK8 NFKB1 MAP3K7IP1 PIK3CA IL1A SQSTM1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY CALM1 ANXA1 ADRB2 NPPA PIK3R1 NFKB1 CORIN PIK3CA RELA GNAS NR3C1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 VAV3 ARHGEF10 FARP1 ARHGEF12 ARHGEF2 ARHGEF15 ARHGEF17 ARHA PLEKHG6 ARHGEF18 MYO9B ARHGDIB ARAP1 DEF6 VAV1 NET1 BCR CDKN1B OBSCN ARHGEF3 ARHGEF5 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADRB2 CFTR ADCY1 PRKAR1B PRKAR1A EZR NHERF1 PRKACG BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY CDC2 KHDRBS1 MAPK1 HRAS MAPK3 PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY LRP8 DAB1 RELN CDK5 MAP1B CSNK2A1 ARHA CDK5R1 PAFAH1B1 HEL2 IQGAP1 PPP2R5D CDC42 DYNC1H1 NUDC NDEL1 DYNLT1 HEL-S-303 PLA2G7 KATNA1 LRPAP1 RAC1 CDK5R2 VLDLR BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY PAK1 NFKB1 PIK3CA MAPK1 TFDP1 CDK2 ARHA CCND1 HRAS CCNE1 IKBKB CHUK NFKBIA RB1 CDKN1A RAF1 CDKN1B PIK3R1 CDK6 CDK4 IKBKG RELA MAPK3 RAC1 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY HEL-S-28 MAPK1 JUN SYK MAP3K1 CHUK NFKBIA ITGB3 PIK3R1 CDC42 MAP3K14 RELA ITGAV MAPK3 RAC1 MAPK8 CD44 VAV3 NFKB1 PTK2B PIK3CA ARHA MMP2 opn FOS ROCK2 PIP5K1A MMP9 PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY TOP2A NOTCH1 RRAD STXBP4 SFN DLX5 NR1i1 DLX6 TBXT HELLS GPX2 TCF7L1 YAP1 ADRM1 KRT5 POU2F2 RUNX1 GSK3B FOSL2 AXL FBXW7 FASN KRT14 RAB38 PPP2R5A ADA NRG1 MDM2 BRCA2 CEBPD HES1 WWP1 CDKN2A BDKRB2 ITCH CCNB2 ATM MRE11A IL1A TP63 PERP PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY CTNND1 PIK3CA ARHA VASP SRC PIK3R1 FYN CASR JUP FMN1 ZYX CTNNA1 AJUBA PLCG1 RAC1 EGFR PIP5K1A BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY IL4 IL2 IL5 IFNG CXCR3 CCR5 IL12RB1 IL18R1 CD40LG CXCR4 CSF2 CCR1 IFNGR1 IFNGR2 CCL4 TGFB1 CCL3 CCR7 CCR4 CCR3 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 IFNG MAPK1 STAT3 MAP3K1 CAMK2A IL1B CAMK2G PIK3R1 RAP1A CEBPB IFNGR1 CRKL RAPGEF1 MAP2K1 MAPK3 CREBBP CBL JAK1 CAMK2D IRF-1 PTPN11 PIAS1 IRF9 MTOR PIK3CA MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL ENPP1 COL4A2 COL4A1 COL4A4 COL4A3 opn COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY THY1 FGA KNG1 SPON2 F10 HEL-S-62p CD40LG ICAM3 GP1BA ICAM4 HEL-S-78p CYR61 ITGAM PROC FCGR2A ITGAX F11R TGFBI ICAM2 PLAT JAM3 PLAUR VCAM1 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY CDK2 GADD45A ATM CCND1 CCNE1 BCL2 RB1 CDKN1A BAX PCNA TIMP3 CDK4 MDM2 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY IL4 SHC1 IRS1 IL2RG RPS6KB1 GRB2 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4E EIF4A2 AAG1 EIF4A1 EIF3A EIF4G1 BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK8 DUSP4 DUSP2 DUSP9 MAPK14 MAPK3 DUSP8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY IFNAR2 EIF2AK2 TNFRSF11A MAPK8 TNFSF11 IRF9 NFKB1 IFNAR1 FOS FOSL2 TRAF6 FOSL1 RELA IFNB1 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL4 IL3 IL5 CD40 IFNG CD5 CD7 TLR7 CD2 CD33 ITGAX CSF2 IL10 IFNA1 IFNB1 IL13 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 GNGT2 GNAT2 RDH12 ARR3 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY AXIN1 BTRC FZD1 MAP3K7IP1 CSNK2A1 HNF1A CCND1 HDAC1 APC GSK3B MYC WIF1 PPP2CA WNT1 MAP3K7 SMAD4 NLK NR1C2 CREBBP DVL1 CTBP1 FRAT1 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY GNB1 ARHGEF1 HEL-S-47e VASP PIK3R1 ZYX MYL2 GNAZ GNAI3 GNAI1 GNA14 SNX1 SNX2 F2R F2RL2 GNA15 PKN1 GNA11 PIK3CA TRPC6 ARHA GNAO1 PLCB3 PLCB1 PLCB2 GNA13 GNG2 PRKCB ROCK1 PRKCA F2 ROCK2 BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 ADCY1 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 GNAS PRKAR1B PRKAR1A PRKACG BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL4 IL2 CD40 TNFSF6 IL10 CD40LG HLA-DRB5 HLA-DRB4 CD80 HLA-DRB3 HLA-DRB1 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY PAK1 PAK4 MLST8 MAPK1 MAP2K4 NCK1 MAP3K1 APC SRC CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD RAB5A EIF4E PARD6A SHC1 PIK3R1 PTPN1 PRKCZ CRKL ARF6 SNAI1 MAP2K1 PLCG1 MAPK3 RAC1 PRKCI PDPK1 CBL PTPN11 GAB2 MAPK8 F2RL2 MTOR NCK2 PIK3CA MAP2K2 ARHA HRAS GRB2 SOS1 INPPL1 RPTOR RAF1 DEPTOR SH3GL2 HGS AKT1S1 NUMB ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PXN RANBP10 MUC20 WASL BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUP210 NUP62 RCC1 NUP153 NUTF2 KPNA2 RAN NUP214 RANBP2 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SLC2A4 MAPKAP1 SFN AKT3 KPNA1 MLST8 TBC1D4 RICTOR BAD HEL2 CHUK GSK3B SRC FOXO4 FOXO3A PDPK1 HEL-S-93 FOXO1 GSK3A MTOR YWHAQ CASP9 HEL-S-1 PRKDC YWHAG MAP3K5 BCL2L1 CDKN1A RAF1 CDKN1B BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY FYN THBS1 JUN CD36 MAPK14 CASP3 FOS BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY MAPK8 PIK3CA JUN CSNK2A1 STAT3 HRAS MAP2K4 MAP3K1 GRB2 SOS1 EGF FOS STAT1 RAF1 SHC1 PIK3R1 PRKCB MAP2K1 PRKCA PLCG1 MAPK3 EGFR JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNB1 CREB1 MAPK1 SRC PLCG2 PELP1 GNRH1 SHBG PIK3R1 CDC42 MAP2K1 PLCG1 MAPK3 RAC1 GNAZ GNAI3 GNAI1 PIK3CA MAP2K2 HRAS GNAO1 PLCB3 FOS RAF1 PLCB1 PLCB2 GNG2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY SIRT1 NCOA1 KAT2B RXRA SMARCE1 JUN SMARCC1 HDAC1 MAP2K4 MAPK14 GSK3B SRC REL CARM1 CEBPA TMPRSS2 KLK3 HOXB13 NR2C2 KAT5 MDM2 ZMIZ2 MAP2K6 TRIM24 KAT7 SRY SPDEF POU2F1 NR3C1 CREBBP NR0B1 SENP1 APPBP2 FOXO1 PDE9A MAPK8 PKN1 RXRB RXRG GATA2 HDAC7 EP300 EGR1 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY GNB1 GNA14 F2RL3 F2RL2 GNA15 GNA11 ARHA PLCB2 GNA13 GNG2 MYL2 ROCK1 F2 ROCK2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY MBD3 HEL-S-162eP GREB1 TUBA4A TUBA1A TUBA2 MTA3 HDAC1 HSPB2 HEL-S-130P HEL-S-102 HEL-S-87p SNAI2 SNAI1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGAM SELP SELL SELE PECAM1 CD44 ITGA4 ITGB1 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY CAPNS2 MAPK1 JUN ACTA1 SHC1 FYN ZYX RAP1A CRKL RAPGEF1 MAP2K1 ACTN2 MAPK3 TLN1 MAPK8 HEL114 sm-M20 MAP2K2 ARHA CSK HRAS TNS1 ITGB1 GRB2 SOS1 BCR RAF1 ROCK1 ACTN1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAPK8 CREB1 MAPK1 JUN MAPK14 HEL-S-166mP KEAP1 FOS CRYZ POR FXYD2 MAFG MAFF MAFK NFE2L2 PRKCB PRKCA HMOX1 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY CD3G CD3E PTPRC CD3D LCK ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 ZAP70 PRKAR1B PRKAR1A CREBBP PRKACG BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ARHGEF1 F2RL3 F2R PIK3CA PTK2B sm-M20 ADCY1 ARHA PLCB1 PIK3R1 MAP3K7 GNA13 PRKCB ROCK1 PRKCA F2 BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY RXRA FABP6 ABCA1 LDLR NR0B2 NR1H4 NR1H3 BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A TERF2 HEL-S-71 RFWD2 H2AX RBBP8 BLM KAT5 MDM2 NBN CTBP1 TOP3A HEL-S-1 ATM MRE11A CHEK2 RAD50 FANCD2 RAD17 BRCA1 TRIM28 RAD9A MDC1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY HDAC5 RBL1 CSF1R JUN CSF1 ETV3 HRAS ETS2 SIN3B SIN3A FOS HDAC2 E2F4 NCOR2 BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO2 DICER1 AGO4 AGO1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY PTPN11 CD3G IL2 CD3E CD3D PIK3CA LCK HLA-DRB5 HLA-DRB4 GRB2 CD80 HLA-DRB3 HLA-DRB1 ITK CTLA4 PIK3R1 ICOS PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY SLC2A4 STXBP4 SFN INS TBC1D4 YWHAQ HEL-S-1 HEL2 YWHAG PPP1CC GSK3B HEL-S-42 INSR PRKCZ ASIP LNPEP PPP1R3A GYS1 TRIP10 STX4A VAMP2 PRKCI HEL-S-93 BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY RECK TIMP4 TIMP3 HRAS MMP2 MMP14 TIMP1 MMP9 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY CTDSP1 NUP153 CTDSP2 CTDSPL KPNA2 MAPK1 SMAD2 UBE2I SMAD4 MAP3K1 MAPK3 NUP214 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY APC GSK3B NPPA MAP3K7 MYL2 SMAD4 TGFB1 DVL1 AXIN1 FZD1 TGFBR1 TGFBR2 BMP10 TGFBR3 BMPR2 GATA4 NPPB DKFZp781O1323 HNF1A NKX2-5 ATF2 ACVR1 SMAD1 MEF2C RFC1 NOG BMP7 BMP5 BMP4 WNT1 BMP2 BMPR1A BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY PPP3CC CALM1 HDAC5 PIK3CA MAPK14 PIK3R1 MAPK7 INSR MYOD1 AVP MAP2K6 CAMK1 CAMK1G NFATC2 NFATC1 IGF1 CABIN1 IGF1R PPP3CA BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 RARA HRAS PML RB1 TNFRSF1A TNFRSF1B TNFSF6 TNF SP100 SUMO1 PAX3 PRAM1 CREBBP PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY AMH BMP7 FKBP1A BMPR2 DKFZp781O1323 SMAD4 ACVR1 SMAD1 AMHR2 TLX2 SMAD9 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY PABPC1 PDK2 MTOR RPS6KB1 PIK3CA MAPK1 MAPK14 EIF4E IRS1 PIK3R1 EIF4A2 AAG1 EIF4EBP1 PRKCB EIF4A1 PRKCA GHR MAPK3 PTEN PDPK1 EIF4G1 PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY ARF1 DAPP1 PIK3CD NRAS PIK3R3 BASH PIK3R2 CYTH1 PLEKHA1 PLEKHA2 SYK BTK SGK1 LAT BLK ARF5 YES1 SRC PLCG2 LYN c-fgr ITK PIK3R1 FYN RAP1A ARF6 PLCG1 FOXO3A PTEN RAC1 PDPK1 PIK3CA LCK ARHA HRAS CYTH2 INPPL1 ZAP70 PIK3R5 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY HEL-S-32 OGDH ACO2 SDHA CS FH SUCLA2 PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PMAIP1 NR1i1 EGR2 GDF15 GPX2 GADD45A IKBKB SP1 CHUK PML DICER1 BAX TP53I3 SMARCD3 ADA OGG1 NOC2L MDM2 EVPL CLCA2 FLOT2 NQO1 TFAP2C DST AEN SSRP1 DHRS3 ITGB4 BBC3 TRAF4 WWP1 MFGE8 CDKN2A SHH YWHAQ ITCH PLK1 SERPINB5 CDKN1A FDXR TP63 S100A2 EP300 PERP BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 CDK8 CDK7 CDK3 CDC2 CDK5 TRIM25 SFN CDK2 CCNB2 CDK6 CDK4 SMURF2 SMURF1 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY CHRNA1 SNAP25 CHRM1 STX1A VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY CCNB1 PAK1 PPP2R1A PPP2CA RAB1A ECT2 FBXW11 CDC2 ERCC6L BUB1B ARHA CDC14B CDC20 GOLGA2 PLK1 AURKA HEL-S-80p FBXO5 CDC25B SGOL1 CLSPN WEE1 NINL CENPU HCTP4 KNTC2 C13orf34 TUBG1 FZR1 CENPE STAG2 PRC1 GORASP1 NUDC INCENP KIZ SPC24 TPT1 KIF20A ROCK2 PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 TFDP1 CCNE1 TBP CEBPA MAPK11 CSF2 RBBP4 E2F2 E2F3 E2F4 CEBPB CEBPD CREBBP CDKN2A ELF1 CDK2 CCND1 SPI1 SUV39H1 AATF BRD2 SFTPD UBTF RUNX2 RBP2 ATF7 HDAC3 BGLAP GSC CBX4 PPP2R3B MAPK9 TAF1 PPARG JUN HDAC1 MAPK14 SMARCA4 PPP2CA CCND2 CDK6 MDM2 CTBP1 ATF2 MEF2C RB1 CDKN1A RAF1 CDKN1B CDK4 MYOD1 CCND3 EP300 PAX3 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 ATM CHEK1 MYT1 CDC25B WEE1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY NGF CREB1 NRAS SFN AGAP2 TRPC3 BAD TRPV1 CAMK4 HEL2 NTRK1 CAMK2A GSK3B SRC SHC1 PIK3R1 PLCG1 FOXO3A PDPK1 HEL-S-93 YWHAQ PIK3CA HEL-S-1 CCND1 HRAS YWHAG GRB2 SOS1 EGR1 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PAK1 PIK3R1 CDC42 PDGFRA PIK3CA ARHA RAC1 WASL BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY PPP3CC SLC2A4 CALM1 HDAC5 CAMK1 NR1C1 PPARGC1A CAMK1G ESRRA CAMK4 PPP3CA PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 RPS6KB1 NCK2 PIK3CA BAD HRAS HEL2 GRB10 GRB2 PRKD1 SOS1 RAF1 SHC1 IRS1 PIK3R1 PTPN1 PRKCZ CRKL PXN PDPK1 CRK HEL-S-93 IGF1R BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY PRF1 CD3G CD3E TNFSF6 CD3D HLA-A B2M BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY NGFR NGF DPM2 RPS6KA5 MAPK1 MAP2K2 STAT3 HRAS ITGB1 GRB2 SOS1 MYC PPP2CA RAF1 RPS6KA1 SHC1 PDGFRA GNAS MAP2K1 MAPK3 EGFR IGF1R BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY ZNF183 GPD2 UQCRC1 SDHC SDHA SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY EIF4E FBL NCL GPT MAPK14 PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY RARA HDAC3 CDK7 RARB MAPK8 NCOA1 CCNH CDC2 NR1i1 RXRB KAT2B RXRA MNAT1 MAPK1 HDAC1 MAPK14 RXRG EP300 RBP1 PRKCA MAPK3 CREBBP NR1B3 NCOR2 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY PPP3CC CALM1 NFATC4 NFATC3 SP1 SP3 CDKN1A PRKCB NFATC2 PRKCA MARCKS PLCG1 NFATC1 PPP3CA BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 KPG_011 ALOX5 ALOX5AP PTGES PLCB1 TBXA2R PTGIR PTGER4 PTGER1 CYP2J2 PTGFR PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY CTNND1 SRC RAB5A CDH2 RAB7A IQGAP1 FYN PTPN1 CDC42 JUP CTNNA1 ARF6 RAC1 CREBBP IGF1R SNX1 RET HRAS ROBO1 CASP3 SLIT1 NTRK2 MMP7 EGF BDNF MMP3 IGF2 ADAM10 ZBTB33 MEP1B HGS GDNF PTPN6 GNA13 RIN2 EGFR TIAM1 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY NOTCH1 RBPJ FURIN ADAM17 PSEN1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY CTNND1 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN ZYX CTNNA1 MYL2 ARF6 PIP5K1C STX4A IGF1R NECTIN2 HEL114 ARHA EGF EFNA1 HGF CYFIP2 NCKAP1 AQP5 AQP3 ROCK1 LPP ACTN1 LIMA1 MYO6 EPHA2 EGFR MGAT3 PLEKHA7 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY PIAS2 PIAS1 MDM2 SUMO1 HDAC1 RAN RANBP2 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL4 NR1i2 IL2 IL12B CD40 IFNG IL12A IL12RB1 IL18R1 IL2RA CD40LG HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 IFNGR1 IFNGR2 IL18 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY MAPK8 NFKB1 TNFSF12 TNFSF13 TNFRSF13C TRAF3 TNFRSF17 MAPK14 TNLG7A TNFSF12-TNFSF13 CHUK TRAF2 TRAF6 MAP3K14 RELA BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 CASP6 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 LMNA DFFB PRF1 DFFA PARP1 CASP2 BIRC2 BIRC3 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY IL6 MAP2K3 JUN IL1RN IRAK1 MAPK14 IKBKB MAP3K1 IL1R1 IRAK2 CHUK NFKBIA IRAK3 IL1B MYD88 MAP3K7 TRAF6 MAP3K14 RELA MAP2K6 TGFB1 MAPK8 NFKB1 MAP3K7IP1 IL1A TNF IFNA1 IFNB1 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFA PIK3CA MAPK1 ADCY1 ARHA SMPD2 SPHKAP SPHK1 ITGB3 S1PR1 PLCB1 PIK3R1 PDGFRA PRKCB SMPD1 ITGAV PRKCA MAPK3 RAC1 BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 PSMB9 HLA-DRB5 HLA-DRB4 HLA-A HLA-DRB3 B2M HLA-DRB1 BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY HMGCS1 MBTPS1 MBTPS2 LDLR SREBF2 LIMA1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD PIK3R3 PIK3R2 MAPK1 MAP2K4 TNFRSF10C IKBKB MAP3K1 CHUK TNFRSF10B TNFRSF10A TRADD TNFRSF10D TRAF2 PIK3R1 RIPK1 IKBKG TNFSF10 DAP3 SMPD1 MAPK3 CASP10 MAPK8 PIK3CA CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY NFKB1 MAP3K7IP1 TNFAIP3 MAP3K1 IL1R1 IKBKB CHUK NFKBIA TRADD FADD IL1A TNFRSF1A MYD88 TNFRSF1B TRAF6 RIPK1 MAP3K7 IKBKG MAP3K14 RELA TNF PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR NONO CHEK1 NR1D1 NPAS2 hCG_2014051 PER2 PER1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY RARA NCOA1 GTF2A1 KAT2B RXRA TBP NCOR2 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF1 ARHGEF11 ARHGAP1 STM7 PFN1 HEL114 sm-M20 ARHA BAIAP2 LIMK1 ARHGEF5 MYL2 ROCK1 ARHGAP5 TLN1 ARHGAP4 OPHN1 PIP5K1A BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY TFRC RAB5A HGS EEA1 TF EGF EGFR BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY MAPK1 SPRY4 PTPRB HRAS SPRY2 SPRY1 GRB2 SOS1 EGF RAF1 SHC1 MAP2K1 MAPK3 EGFR CBL PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNAI1 GNA14 VEGFA GNA15 GNA11 AKT3 MAPK1 ARHA GNAO1 S1PR3 S1PR2 SRC ITGB3 S1PR1 FLT1 CXCR4 GNA13 ITGAV MAPK3 RAC1 GNAZ GNAI3 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY STAT5B MAPK8 PIK3CA JUN BAD HRAS MAP2K4 MAP3K1 GRB2 SOS1 FOS MYC STAT1 BCR RAF1 PIK3R1 CRKL MAP2K1 MAPK3 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAPK1 sm-M20 ARHA HRAS PIK3C2G RAF1 PLCB1 LIMK1 MYL2 PRKCB GNAS MAP2K1 PRKCA MAPK3 ROCK2 CCL11 CCR3 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY KITLG CDC6 CDK2 CCNE1 MCM3 CDT1 MCM7 CDKN1B ORC6 ORC1L ORC3 ORC2 MCM5 MCM6 MCM2 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAPK8 NFKB1 MAPK1 BAD CASP8 MAP2K4 BCL2 MAP3K1 TRADD FADD TRAF2 RAF1 TNFRSF1A BAX RIPK1 RELA NSMAF AIFM1 SMPD1 MAP2K1 MAPK3 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY GPLD1 ASAP2 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY IFNAR2 STAT1 STAT2 IRF9 TYK2 IFNAR1 IFNA1 IFNB1 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY SIRT1 KAT2B NCOR1 TNFRSF1A RBBP4 CREBBP MBD3 GATA2 UBE2I SUMO1 HDAC7 RAN NCOR2 HDAC10 HDAC3 HDAC11 CHD4 CHD3 MBD3L2 SMG5 HDAC5 SIRT4 PPARG SIRT5 SIRT6 STAT3 SIRT7 HDAC1 SIN3B SIRT2 SIN3A SIRT3 MAX NFKBIA SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 MTA2 MBD2 RELA GATAD2B GATAD2A TFCP2 MXD1 SMURF1 NFKB1 HDAC2 YY1 TNF EP300 RANBP2 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY PPP3CC CALM1 MAPK1 JUN SYK BTK MAP2K4 NFATC4 MAP3K1 LYN SHC1 PIK3R1 FCER1A MAP2K1 PLCG1 MAPK3 FCER1G MS4A2 MAPK8 PIK3CA HRAS NFATC3 GRB2 SOS1 FOS VAV1 RAF1 PRKCB NFATC2 NFATC1 PPP3CA PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY NGFR NGF NRAS MAPK1 NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 STAT3 ELMO1 SHC1 PIK3R1 PRKCZ CRKL MAP2K1 PLCG1 MAPK3 RAC1 PRKCI MATK FRS2 MCF2L FRS3 FAIM PTPN11 GAB2 SHC3 MAGED1 NTF4 NTF3 SH2B1 PIK3CA NTRK3 ARHG RIT1 ARHA HRAS RIT2 GRB2 SOS1 NTRK2 BDNF SQSTM1 DOCK1 DYNLT1 TIAM1 PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY CREB1 MAPKAP1 NRAS RPS6KA5 MLST8 MAPK1 RICTOR BRAF ATF1 ARPC4 ARPC5 MAP2K4 MAP3K1 BAIAP2 ARPC2 ARPC3 SRC IQGAP1 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA RIN1 PIK3CD PLD2 SFN PIK3R3 PIK3R2 MAPK9 JUN BAD STAT3 HEL2 PPP2R1A PPP2R2A RAB5A PPP2CA PIK3R1 PRKCZ MAP2K1 MAPK3 RAC1 PDPK1 HEL-S-93 RPS6 MAPK8 F2RL2 MTOR YWHAQ PIK3CA HEL-S-1 MAP2K2 HRAS USP6NL ATF2 ARF4 YWHAG SMAD1 GRB2 BRK1 MEF2C SOS1 RPS6KA4 EGF ZFP36 BCL2L1 KSR1 STAT1 MYL11 RAF1 SH2D2A WASF2 MAP2K5 MAPK7 MAP3K2 PPP5C CYFIP2 NCKAP1 EGR1 ARPC1B ACTR3 ACTR2 WASL EGFR BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY RB1 PPP2CA TEP1 TNKS TERT XRCC5 TERF1 BCL2 PRKCA EGFR MYC IGF1R BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY IRF-1 NFKB1 KAT2B HMGB1 RELA JUN ATF2 IRF3 IRF2 CREBBP IRF4 IRF7 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAP3K6 MAPK6 MAPK4 CREB1 PAK1 MAPK12 RPS6KB2 MAP3K10 RPS6KA5 MAP3K13 MAPK1 MAP2K3 MAPK13 MAP4K2 MAP2K4 MAP3K1 CHUK TRADD TRAF2 CEBPA MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 MAPK9 JUN MAPK14 IKBKB SP1 MAX NFKBIA MAPK10 MYC SHC1 MAP3K7 RELA MAP2K1 HEL-S-31 MAPK3 TGFB1 RAC1 TGFBR1 MAPK8 NFKB1 RPS6KB1 MAPKAPK3 MAP3K11 MAP2K2 HRAS ATF2 GRB2 MAP3K5 RPS6KA4 STAT1 RAF1 MAP4K3 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP2K5 MAPK7 MAP3K2 MAP4K1 RPS6KA2 MAP3K8 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY CCNB1 SIRT1 SFN RBL2 KAT2B ZFAND5 MAPK9 BCL2L11 CSNK1G3 GADD45A CSNK1D SGK1 FBXO32 HEL2 IKBKB CSNK1G2 CHUK MAPK10 CSNK1G1 RALB BCL6 TNFSF6 FOXO4 FOXO3A hCG_2014051 CREBBP HEL-S-93 FOXO1 CSNK1A1 MAPK8 YWHAQ CDK2 HEL-S-1 G6PC1 YWHAG PLK1 CDKN1B EP300 RAN RALA PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY MAPK8 JUN MAP2K4 LAT MAP3K1 GRAP2 LCP2 MAP3K7 MAP4K1 PRKCB CRKL CRK MAP3K8 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY FANCA ATM MRE11A HUS1 FANCE FANCG TREX1 FANCF RAD50 RAD51 CHEK2 FANCD2 RAD17 BRCA1 RAD1 ATR BRCA2 RAD9A CHEK1 NBN PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PAK1 PIK3CD NRAS PIK3R3 PIK3R2 MAPK1 STAT3 NCK1 SRC SHC1 PIK3R1 PTPN1 PIP5K1C PLCG1 MAPK3 TLN1 GNAI3 GNAI1 PTPN11 NCK2 PIK3CA HRAS GRB2 SOS1 EGF STAT1 PTPN6 WASL EGFR BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TRAF2 TNFRSF1A TNFRSF1B RIPK1 TNF CASP8 BIRC3 BAG4 TRADD FADD BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY EIF2AK2 MAPK8 NFKB1 MAP3K7IP1 MAP2K3 JUN TLR7 MAP2K4 MAPK14 MAP3K1 IKBKB CHUK NFKBIA FOS PGLYRP1 MYD88 TLR3 TRAF6 MAP3K7 IKBKG MAP3K14 RELA MAP2K6 NR1C1 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY RAF1 PLCB1 KCNA1 KCNA2 MAPK1 KCNA3 MAP2K2 ADRBK1 ADCY1 GNAS MAP2K1 MAPK3 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY PDK2 MTOR RPS6KB1 PIK3CA EIF2B5 GSK3B INPPL1 PPP2CA EIF4E PIK3R1 EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 PTEN PDPK1 IGF1 IGF1R BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY PAK1 PIK3CA PTK2B SYK LAT ITGB1 HLA-A VAV1 B2M KLRC2 PIK3R1 KLRC3 PTPN6 KLRC4 KLRD1 KLRC1 MAP2K1 MAPK3 RAC1 IL18 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY CASP10 RIPK2 MAPK8 PAK1 CASP6 JUN LMNB2 CASP8 MAP2K4 PRKDC MAP3K1 CASP3 ARHGDIB LMNA FADD RB1 DFFB DFFA PARP1 MAP3K7 TNFSF6 FAF1 PTPN13 SPTAN1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 GABRA3 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY RARA RARB NR1i2 NR1i1 PPARG NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCG5 ABCC2 CYP4A11 CYP8B1 CYP26A1 CYP2C9 CYP24A1 CYP1A2 CYP2E1 ABCG1 ABCC3 ABCB1 ABCB4 ABCA1 NR0B2 ABCB11 NR1H4 NR1H3 NR1C2 NR1B3 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY NEUROG3 NOTCH1 BGLAP NCOA1 STAT3 HDAC1 NCOR1 GATA1 RBBP8 KDR MYB GHR HES1 CREBBP CTBP1 CAMK2D GATA4 TCF3 RB1 CDKN1B PARP1 KDM1A TWIST1 MAML2 MAML1 RBPJ MYOD1 GATA6 YY1 ASCL1 HIF1A HEY2 EP300 SPEN HES6 GAA RCAN1 ID1 RUNX2 NCOR2 PTF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY TSC1 RHEB PDK2 MTOR RPS6KB1 PIK3CA EIF3A PPP2CA EIF4E PIK3R1 EIF4A2 AAG1 TSC2 EIF4EBP1 EIF4A1 PTEN PDPK1 EIF4G1 BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY CD3G PTPRC FYN CD3E ZAP70 CD3D LCK HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY THY1 VTN EDIL3 VEGFA L1CAM SDC1 CD47 FBN1 COL1A1 SPHK1 ITGB3 F11R PECAM1 HMGB1 KDR ITGAV PLAUR LAMA4 TGFBR2 LAMC1 IBSP FGA ITGA2B opn SDC4 HEL-S-78p CYR61 COL1A2 LAMB1 TNC TGFBI THBS1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY KALRN HEL-S-47e DOCK6 ARHGAP17 PREX2 PREX1 CHN1 RALBP1 ELMO1 SPATA13 DOCK2 VAV2 TRIO ARHGEF25 RAC1 VAV3 ARHGAP1 ARHGEF2 SOS1 DEF6 VAV1 BCR RASGRF2 RASGRF1 DOCK1 TIAM1 ARHGEF7 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY ARHA IRAK1 HSPD1 IKBKB CHUK IRAK2 IRAK4 LY96 TICAM1 VCAN TIRAP MYD88 TLR1 TLR3 SFTPA1 IKBKG CD14 HMGB1 S100A9 TLR4 S100A8 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY MAP3K1 CHUK NFKBIA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MDM2 MAP3K14 RELA PSEN2 PSEN1 ACTG1 CDK11A SPTAN1 MAPK8 CASP6 NFKB1 NUMA1 LMNB2 CASP9 CASP8 PRKDC BCL2 CASP3 ARHGDIB MAP3K5 BAG4 LMNA FADD RB1 DFFB DFFA TRAF1 PARP1 TNFRSF1B TNF BIRC2 BIRC3 APAF1 BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PLCB1 NFKB1 RELA PRKCB PRKCA NFKBIA BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY MAPK8 NFKB1 JUN GADD45A ATM MRE11A TP73 NFKBIA CDKN1A RAD50 RAD51 CHEK2 RBBP8 BRCA1 MDM2 RELA CHEK1 NBN PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY GNB1 HDAC3 HDAC10 HDAC11 HDAC5 CAMK4 HEL2 GATA1 BCL6 TUBA1B NR3C1 RFXANK TUBB2A BCOR ANKRA2 HEL-S-1 MEF2C GATA2 GNG2 ADRBK1 UBE2I HDAC7 SUMO1 RAN RANBP2 NCOR2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY NGFR RAF1 NGF DPM2 CDK5 MAPK1 MAP2K2 CDK5R1 EGR1 HRAS MAP2K1 MAPK3 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY HEL-S-28 CREB1 RICTOR JUN GSK3B IQGAP1 CDC42 RUVBL2 ZYX RUVBL1 SNAI1 RAC1 ILKAP PPP1R14A GIT2 PPP1R14B PPP1R14C NCK2 PARVA PARVB ARHG PARVG NACA CCND1 CDC37 TNS1 ELMO2 LIMS1 AURKA PARP1 CKAP5 TACC3 ACTN1 PXN ARHGEF7 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY ARF1 PLD2 KDELR1 CYTH2 GOSR2 USO1 CLTA AP2A1 COPA AP2M1 GBF1 CLTB RAC1 ASAP1 PIP5K1A PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY GNAI1 GNA14 GNA15 GNA11 GNAO1 S1PR3 S1PR2 SPHK1 S1PR1 SPHK2 SGPP1 SGPL1 S1PR5 ABCC1 S1PR4 GNA13 GNAZ GNAI3 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY SHH PTCH1 PIK3CA GAS1 PIK3R1 STIL DHH HHIP PTCH2 ADRBK1 IHH DKFZp686L0365 PTHLH SMO LRPAP1 BOC CDON BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY FLT3 KITLG EPO IL3 IL6 IL9 CSF3 IL1A CSF2 TGFB1 CCL3 IGF1 IL11 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B NGF BTG1 BTG2 CCND1 PRMT1 CHAF1A PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY EPHA7 EPHA8 EFNA3 EFNA2 EPHA1 EPHA3 BLK YES1 SRC LYN c-fgr EPHA4 FYN VAV2 CRKL PLCG1 CRK CBL VAV3 CDK5 ARHGEF15 LCK ARHA EFNA1 PIK3R5 ROCK1 EPHA2 EFNA5 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NCOA1 SMARCE1 NR0B2 NR3A2 NEDD8 HEL-S-62p UBA3 UBE2M DDX54 ZNF14 NR0B1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MTOR MAPK1 STAT3 MAPK3 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY IL1A ACTA1 MAPKAPK2 TNFSF6 MAPKAPK3 CASP9 TNF BCL2 CASP3 HSPB2 HEL-S-102 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY SLPI ELA2B CELA1 ELANE CXCL8 CELA2A CELA3B GRN PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY FOXO1 SIRT1 MEF2D KAT2B PPARGC1A SIRT7 SIRT2 SIRT3 CDKN1A BAX ACSS2 H4C9 FHL2 MYOD1 HOXA10 HIST1H1E ACSS1 EP300 FOXO4 TUBA1B FOXO3A CREBBP TUBB2A PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY CD3G CD3E NRAS BCL10 CD3D PRKCE LAT IKBKB CHUK GRAP2 HLA-A B2M LCP2 PRF1 SHC1 FYN TRAF6 IKBKG MAP3K14 RAP1A PAG1 CD8B PLCG1 STIM1 TRPV6 PDPK1 ORAI1 CBL CARD11 PTPRC LCK CSK HRAS GRB2 CD80 SOS1 VAV1 PRKCQ ZAP70 PTPN6 CD8A PRKCB PRKCA MAP3K8 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY HEL-S-28 PDK2 PIK3CA MAPK1 ITGB1 GRB2 SOS1 CDKN1B SHC1 PIK3R1 TNFSF6 FOXO3A MAPK3 PTEN PDPK1 EGFR PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY EEF2K pk SNTA1 MAPK12 PKN1 MAP2K6 MAP2K3 MAPK13 CCND1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY IL6 BGLAP CCNA2 JUN LIF SP1 FOSL2 GJA1 CCL2 FOSL1 PLAUR ITGB4 CDKN2A TXLNG THBD JUNB JUND USF2 DCN MGP CCND1 IVL ATF4 MMP2 NFATC3 COL1A2 LAMA3 CXCL8 EP300 NFATC2 HMOX1 NFATC1 MMP9 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY HMBS CPOX HBB GATA1 HBA2 FECH ALAS1 ERAF ALAS2 UROD UROS BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY STAT5B PIK3CA PTK2B LCK BCL2 NMI PIK3R1 FYN IL7 IL7R EP300 CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY APP PLG PLAT F9 F11 COL4A2 COL4A1 COL4A4 COL4A3 F2 COL4A6 COL4A5 BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 CPSF2 CSTF2 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY IL4 CD3G CD3E IL12B CD3D IL12A IFNG MAP2K3 MAP2K6 CD8B CCL4 CCL3 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 IL18RAP RIPK2 SOCS1 RELB PPP3R1 HLX TBX21 GADD45B GZMA STAT3 GADD45G MAPK14 NFKB2 IL1R1 HLA-A B2M IL1B RAB7A IL2RG TNFSF6 RELA IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 SPHK2 CD8A IL18 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY PPP3CC CALM1 CD3G CD3E CD3D JUN MAP2K4 NFATC4 LAT MAP3K1 NFKBIA SHC1 PIK3R1 FYN RELA MAP2K1 PLCG1 MAPK3 RAC1 MAPK8 NFKB1 PIK3CA LCK HRAS NFATC3 GRB2 SOS1 FOS VAV1 RAF1 ZAP70 PRKCB NFATC2 PRKCA NFATC1 PPP3CA BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CDKN2A TGFBR1 TGFBR2 MTOR TGFBR3 RPS6KB1 PIK3CA DKFZp781O1323 SMAD1 CTCF CD79B CD79A MYC PPP2CA CDKN1B PIK3R1 MDM2 SMAD4 TGFB1 PTEN BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY ARHGEF1 PLCB1 PKN1 GNA13 sm-M20 PRKCB ROCK1 PRKCA ARHGAP5 PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY MCF2L HEL-S-47e VAV3 ARHGAP1 DOCK6 ARHGAP17 FARP2 RALBP1 APC ITSN2 SPATA13 DOCK9 FGD1 DOCK10 DOCK11 VAV2 CDC42 ARHGEF25 PLCG1 ITSN1 ARHGEF7 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY CCNA2 MAPK1 CDK2 ARHA ITGA1 CCNE1 ITGB1 SRC CDKN1A RABGGTB RABGGTA PTP4A1 PTP4A2 PTP4A3 ATF5 EGR1 ROCK1 TUBA1B MAPK3 RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY F2R PLG PLAT FGA CPB2 SERPINB2 F13A1 F2 HEL-S-78p PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY PAK1 MAPK1 AGAP2 NCK1 YES1 CAMK2A ELMO1 SRC PIK3R1 FYN TRIO CDC42 MAP2K1 PLCG1 MAPK3 HEL-S-36 RAC1 NTN1 UNC5A UNC5B DCC MAP1B PIK3CA MAP2K2 ARHA DOCK1 WASL PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY MAPK1 BTK MAP2K4 LAT MAP3K1 CHUK SPHK1 LCP2 S1PR1 IKBKG PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB LYN ITK SHC1 PIK3R1 FYN RELA FER FCER1A MAP2K1 FCER1G PLCG1 MAPK3 MS4A2 CBL PTPN11 WIPF1 GAB2 LAT2 MAPK8 DOK1 NFKB1 HCLS1 PLPP1 PIK3CA PLA2G1B FCGR2B MAP2K2 HRAS GRB2 SOS1 VAV1 RAF1 PXN BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY CFD C1QB HEL-S-62p C1QA C1S C4B_2 C8A C4A C6 C7 C9 MASP2 MASP1 CFB MBL2 C1QC BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY DFFB PRF1 DFFA SET GZMA APEX1 HMGB2 CREBBP BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C FUT4 FUT6 FUT5 FUT7 MAN2A2 PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TBXT ZCCHC12 CHD8 CBY1 TCF7L1 FGF4 CAMK4 MED12 SALL4 PITX2 APC MYOG TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 RUVBL2 MDFIC TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 DVL3 CDX4 CDX1 KLF4 CDKN2A BCL9 SP5 TCF4 NEUROG1 MYF5 GIG8 CCND1 SKP1 CYR61 INCENP DKK1 SFN JUN HDAC1 HEL2 MYC SMARCA4 CCND2 SNAI2 TERT CTBP1 HEL-S-93 YWHAQ HEL-S-1 YWHAG MMP2 VCAN HDAC2 TRRAP TNIK CXCL8 EP300 MMP9 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY SLC2A4 STAT5B SOCS1 PIK3CA MAPK1 HNF1A HRAS GRB2 SOS1 RAF1 RPS6KA1 SHC1 IRS1 PIK3R1 PTPN6 INSR PRKCB MAP2K1 PRKCA GHR PLCG1 MAPK3 GH1 BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C6 C7 C9 C1QC C1QB HEL-S-62p C1QA C1S C4B_2 C8A C4A BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY FZD1 NOTCH1 WNT1 RBPJ HES7 NOTCH2 HEY2 HNF1A HES1 DVL1 GSK3B BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY SOCS3 SOCS1 MAPK1 SYK BAD MYC SHC1 PIK3R1 IL2RG TNFSF6 CRKL MAPK3 JAK3 CBL JAK1 STAT5B RPS6KB1 PIK3CA IKZF3 IL2RA HEL-S-69p HRAS IL2RB BCL2 GRB2 SOS1 FOS RAF1 IRS1 NMI PTPN6 PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY LYN PIM1 PTPN11 STAT5B IL5 CSF2RB PIK3R1 CISH PIK3CA SDCBP IL5RA GRB2 PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY TSC1 CREB1 SFN MLST8 HEL2 GSK3B PRKAG1 MYC SMARCD3 PSEN2 SMAD4 EZR HEL-S-93 PRKAA1 MTOR PRKAA2 YWHAQ HEL-S-1 CDC37 BRSK1 YWHAG CRTC2 CAB39 HEL-S-130P STK11 MAP2 RPTOR MARK4 STK11IP STRADA STRADB ETV4 AKT1S1 STK26 TSC2 SIK3 PRKAB1 SIK1 SIK2 PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY NHEJ1 CSNK2A1 XRCC5 POLM CSNK2A2 PRKDC PNKP APLF DNTT CSNK2B POLL APTX PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY CD3G CD3E NRAS CD3D PRKCE LAT NCK1 CHUK GRAP2 LCP2 TRAF6 IKBKG CDC42 MAP3K14 RAP1A PAG1 STIM1 TRPV6 ORAI1 CARD11 FLNA CSK ZAP70 PTPN6 PRKCB PRKCA SLA2 STK39 WAS FYB1 BCL10 IKBKB ITK SHC1 FYN PLCG1 PTEN PDPK1 CBL PTPN11 GAB2 PTPRC LCK HRAS GRB2 CD80 SOS1 VAV1 PRKCQ MAP4K1 MAP3K8 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY RAF1 NRAS MAPK1 BRAF PRKCB HRAS MAP2K1 PRKCA MAPK3 FOS MAP3K8 BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY CPT1A PRKAA1 LEPR PRKAB2 ACACA PRKAA2 LEP PRKAG2 PRKAB1 PRKAG3 PRKAG1 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY IL4 TGFBR1 CD3G IL2 TGFBR2 CD3E CD3D TGFBR3 IFNG TOB2 TOB1 IL2RA SMAD4 TGFB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNAI1 S1PR5 S1PR4 CDC42 MAPK1 GNA13 ARHA GNAO1 PLCG1 MAPK3 GNAZ GNAI3 BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY CDK5 JUND PPP1R1B FOSB GRIA2 BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C6 C7 C9 MASP2 MASP1 MBL2 HEL-S-62p C4B_2 C8A C4A BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFALS IGFBP6 RAPGEF5 IGFBP4 IGFBP5 IGFBP1 SST GH1 GHRH IGFBP2 IGF1 GHRL BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY IL6ST PTPN11 IL6R IL6 JUN CSNK2A1 STAT3 HRAS GRB2 SOS1 FOS RAF1 SHC1 CEBPB MAP2K1 MAPK3 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY IL6ST STAT2 IL6 IL2 TYK2 IL12B IFNG STAT4 IL12A TBX21 IL12RB1 IL17A STAT3 STAT1 IL1B EBI3 IL27 GATA3 IL27RA TNF TGFB1 IL18 JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY CREB1 KCNIP3 CREM JUN OPRK1 PRKAR1B PRKAR1A MAPK3 PRKACG FOS BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY PIK3CA MAPK1 PFN1 ARHA HRAS ITGB1 RAF1 SHC1 PIK3R1 FYN MYL2 MAP2K1 ROCK1 ARHGAP5 MAPK3 TLN1 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY ARF1 GSK3A PFKL RPS6KB1 PRKCE ARHGEF2 EEA1 BAD BTK GSK3B LYN RAB5A VAV2 PRKCZ PFKP AP2A1 AP2M1 PLCG1 RAC1 PFKM PDPK1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY ADAM12 VEGFA ITGB1 opn SRC TNC CSF2 CSF2RA KCNJ15 ADAM2 PXN F13A1 ADAM15 ADAM8 RAC1 VCAM1 VEGFC PAOX NOS2 VEGFD BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY DRD2 PPP2CA PLCB1 CDK5 PPP1R1B CDK5R1 CSNK1D PRKAR1B PRKAR1A PRKACG PPP3CA DRD1 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY STAT1 IL1A HEL-S-10 IL6 IL10RB IL10RA TNF IL10 STAT3 HMOX1 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY SOCS3 IL6 CXCL9 IL18RAP CD3E IL12B IFNG IL17A STAT3 NFKBIA IL1B PIK3R1 CCL2 RELA IL2 IL23R TYK2 NFKB1 IL24 STAT4 ALOX12B CXCL1 IL12RB1 PIK3CA MPO IL18R1 IL19 IL23A IL17F STAT1 TNF NOS2 IL18 PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY ITGB4 LAMA3 LAMB1 LAMC2 ITGA6 LAMC1 LAMB3 LAMA5 LAMA1 LAMB2 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY F2R FGA F10 PROS1 ERAF F7 HEL-S-78p PROC PLG TFPI PLAT COL4A2 SERPINC1 COL4A1 COL4A4 F2 COL4A3 COL4A6 COL4A5 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY IL4 IL3 PPP3R1 IFNG JUN CD40LG CSF2 FOSL1 TNFSF6 POU2F1 IL2 FKBP1A PTGS2 JUNB IL2RA NFATC3 AKAP5 FOS CHP1 BATF3 NFATC2 NFATC1 RCAN1 CABIN1 PPP3CA BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY ACAT1 IL6 CCL2 LPL LDLR CSF1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CALM1 CAMKK1 CREB1 CAMKK2 CAMK1 CAMK1G CAMK4 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY TRIM59 PRDM15 ATP5J HSF2 NDUFV3 XBP1 ABCA3 EBAG9 NR3A2 UBA3 DDX54 POU4F1 POU4F2 CHUK NCOR1 AXIN2 KLRC3 CEBPB NR0B1 GREB1 NEDD8 CCND1 HEL-S-62p UBE2M HEL-S-130P CD82 NR0B2 NCOR2 PRL NCOA1 MED1 JUN HDAC1 MYC COL18A1 SMAD4 CALCOCO1 PCNA MPG BRCA1 SRA1 PHB2 HEL-S-44 PDIA2 SET DSCAM EP300 LMO4 AP1B1 SAFB LCOR PGR TFF1 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKAP TRAF3 CD40LG TNFAIP3 MAP3K1 IKBKB CHUK NFKBIA TRAF6 IKBKG MAP3K14 RELA PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY CCNA2 SMARCAL1 CEP164 PPP2R2B PPP2R1A PPP2CA RAD51 MDM2 BRCA2 CHEK1 NBN ATRIP HEL-S-93 RFC3 RFC4 FBXW11 CDC6 TIMELESS RFC2 RPA1 CDK2 HEL-S-1 HUS1 PLK1 CLSPN MCM7 FANCD2 RAD17 RAD1 MCM2 ATR RAD9A TOPBP1 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCB GNAS PRKAR1B GRK4 PRKAR1A PRKCA PRKACG PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY HEL-S-28 MAPK1 COL16A1 COL14A1 COL12A1 SRC ITGB3 COL10A1 TEM5 COL2A1 F11R COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 KDR COL5A2 COL9A1 ITGAV COL9A3 COL9A2 TLN1 PI4KB IGF1R MFGE8 HEL114 IRS1 VTN EDIL3 VEGFA SDC1 CSF1R CSF1 COL1A1 PIK3R1 MAPK3 RAC1 COL17A1 CBL PTPN11 TGFBR2 VAV3 RPS6KB1 PIK3CA PTK2B ARHA CASP8 opn COL3A1 COL1A2 CDKN1B FGF2 COL4A1 ROCK1 COL4A4 PXN COL4A3 COL4A6 COL4A5 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY PAK1 VAV3 PIK3CA ARHA GRB2 SRC INPPL1 SHC1 PIK3R1 VAV2 EFNA1 ARHGAP35 RAC1 EPHA2 TIAM1 CBL BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2G1 UBE2G2 SNCA SNCAIP SEPT5 SUMO1 UBE2F GPR37 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY SLC23A2 SLC23A1 SLC2A3 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY INS EXOC7 SGK1 GRB10 NCK1 EXOC4 PARD6A SHC1 EXOC3 PIK3R1 PTPN1 HEL-S-42 EXOC6 PRKCZ INSR EXOC5 EXOC2 EXOC1 RAPGEF1 TRIP10 FOXO3A PRKCI PDPK1 CRK CBL GRB14 PTPN11 F2RL2 DOK1 NCK2 RPS6KB1 SH2B2 PIK3CA HRAS GRB2 SOS1 IRS1 EIF4EBP1 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY GNB1 GNA14 GNA15 PRKCE CXCR1 PLCB3 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 GNG2 ADRBK1 PRKCB DKFZp686L0365 PRKCA PDPK1 CBL PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 CSNK1A1 FZD5 GSK3A WNT3A CSNK1D SKP1 APC GSK3B LRP6 AXIN2 hCG_2014051 DVL1 DVL2 DVL3 PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY PIM1 PTPN11 IL3 GAB2 STAT5B PIK3CA SRP9 CNKSR1 HDAC1 GRB2 YWHAG BCL2L1 SHC1 CSF2RB PIK3R1 IL3RA CISH OSM CEBPB PRKACG ID1 HEL-S-93 PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL4 IL6 TH CREB1 IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 NR3C1 TCF7L2 CDKN2A CDC2 JUNB JUND ELF1 CCND1 CRTC1 DMP1 NFATC3 MT2A EDN1 HEL-S-104 FOS CYR61 MAF CBFB NTS MAFG BAG1 PENK TRIP6 GATA2 HIF1A NFATC2 ATF3 NFATC1 COPS5 JUN FOSB SP1 HLA-A MYC GJA1 ACTA1 NPPA FOSL1 MYB TGFB1 PTEN TIMP1 IL2 ATF2 COL1A2 CDKN1B CXCL8 EP300 IL10 EGR1 MMP9 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY PRDM15 ATP5J VTN NDUFV3 INS XBP1 JUN SP1 KLK3 SFTPA1 APOB COL18A1 CEBPB POU2F1 CREBBP SHH FOXA1 FOS FOXA3 FOXA2 CDKN1B SERPINA1 BRCA1 SFTPA2 C4BPB HEL-S-44 CYP2C18 NKX3-1 DSCAM EP300 GCG AP1B1 NR2F2 PISD NFIA SFTPD NFIB SCGB1A1 TFF1 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 HEL-S-32 ACLY PC PDHA1 ME1 SLC25A11 CS BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY NFKB1 CUZD1 MAPK1 JUN HRAS NFKBIA FOS MYC RAF1 PLCB1 RELA TNF PRKCB MAP2K1 PRKCA MAPK3 BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY U2AF1 SNRPD2 SNRPD1 SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY TGFBR1 TGFBR2 FKBP1A BMPR2 MAPK1 DKFZp781O1323 ACVR1 SMAD1 CSNK2B ENG ACVRL1 INHBA ACVR2B ACVR2A SMAD4 DKFZp686L0365 TGFB1 MAPK3 TLX2 ID1 SMAD9 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY CAPNS2 CXCR3 HRAS ITGB1 EGF ACTA1 MYL2 PRKAR1B PRKAR1A EZR TLN1 EGFR PRKACG BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCA4 GTF2A1 SMARCE1 SMARCD1 PS1TP5BP1 SMARCC1 SMARCC2 ARID1A TBP NR3C1 NF1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY PIK3CA MAPK1 ERBB2 BAD CASP9 ARHA HRAS ITGB1 GRB2 SOS1 TFF3 SHC1 PIK3R1 MUC2 TFF2 GHR MAPK3 GH1 EGFR APAF1 TFF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY CARM1 RARA CREB1 RXRA EP300 PRKAR1B PRKAR1A CREBBP PRKACG BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY PIK3R1 MTOR JUND PIK3CA BIRC5 DPF2 ITGB1 CASP3 ZBTB7A CCT4 FOS BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB2 PSMB6 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A HEL-S-276 PSMA4 BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY ADRA1B PRKCB PRKCA BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CD3G CD3E TNFSF6 CD3D CCR5 BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY GRK1 SLC25A18 RCVRN PDE6G RHO SAG PDE6A SLC25A22 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY STAT5B PIK3CA JUN CSNK2A1 STAT3 HRAS GRB2 SOS1 FOS MPL STAT1 THPO RAF1 SHC1 PIK3R1 PRKCB MAP2K1 PRKCA PLCG1 MAPK3 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY NGF IL6 NRAS IFNG NTRK1 AFDN KDR IFNGR1 PAG1 IGF1R ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG MAP2K1 ARHGAP35 JAK3 JAK1 FRS2 GNAI3 FRS3 IL6ST GNAI1 IL6R PTPN11 GAB2 IL2 NTF4 NTF3 PIK3CA NTRK3 LCK MAP2K2 ARHA IL2RA HRAS IL2RB GRB2 SOS1 NTRK2 EGF BDNF STAT1 RAF1 SDC2 LMO4 EGFR PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY EIF2AK2 PDGFA MAPK1 BAD MAP2K4 MAP3K1 NFKBIA CRADD TRADD MYC TRAF2 TNFRSF1A BAX RIPK1 PRKCZ RELA SMPD1 MAP2K1 HEL-S-31 MAPK3 MAPK8 NFKB1 MAP2K2 CASP8 BCL2 HEL-S-130P BAG4 EGF FADD KSR1 SPHK2 RAF1 PAWR MADD AIFM1 CYCS TNF BIRC3 PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY HEL-S-47e PAK1 NRAS MAPK1 BRAF ARPC4 ARPC5 BLK NCK1 BAIAP2 YES1 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 HEL2 GRB10 MYC LYN PPP2CA SHC1 PIK3R1 FYN PTPN1 RAC1 PTPN11 MAPK8 PIK3CA LCK MAP2K2 ARHA GRB2 SOS1 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 PPP2R2B SPHK1 SRC ITGB3 S1PR1 IQGAP1 VAV2 AFDN RAP1A PAG1 RAPGEF1 ITGAV CRK STAT5B JUND CSK PIK3R5 NHERF1 SFN PIK3CD PIK3R3 PIK3R2 MAPK9 JUN STAT3 PPP2R1A MAPK10 RAB5A MAP2K1 PLCG1 MAPK3 ARHGAP35 PTEN HEL-S-93 CBL DOK1 NCK2 YWHAQ HEL-S-1 HRAS USP6NL YWHAG BRK1 ARAP1 KSR1 STAT1 SLA WASF2 ACTN4 DOCK4 MYOCD ACTA2 TAGLN NHERF2 SIPA1 ARPC1B ACTR3 ACTR2 WASL PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY GNB1 GNB5 PDE6G GUCY2D RHO SAG GUCA1B PDE6A GUCA1A GUCA1C GUCY2F RPE65 GRK1 RDH12 RGS9BP SLC24A1 RDH5 GNGT1 CNGA1 LRAT GNAT1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2AK2 EIF2S2 NFKB1 EIF2S1 MAP3K14 RELA NFKBIA CHUK DNAJC3 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY PPP3CC EPN1 PICALM CALM1 NME2 AP2A1 AP2M1 SYNJ1 PPP3CA BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY CHRNA1 RYR2 CALM1 PDE2A PDE3B VEGFA SLC7A1 BDKRB2 CHRM1 PDE3A KNG1 TNNI1 FLT1 ACTA1 KDR PRKAR1B PRKAR1A FLT4 PRKACG PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY PAK1 RRAS MAPK1 PTPN21 BRAF SH3GL1 ARHGAP26 MAP2K4 KLF8 NCK1 YES1 SRC RAP1A RAPGEF1 ITGAV TLN1 CRK BMX HEL114 CCND1 ASAP1 MAPK9 JUN MAPK8IP3 ELMO1 ACTA1 PIK3R1 FYN ARHGEF28 MAP2K1 PLCG1 ARHGAP35 RAC1 MMP14 ARHGEF11 MAPK8 GIT2 NCK2 PIK3CA ARHA ITGB1 GRB2 SOS1 RAF1 DOCK1 GRB7 ACTN1 PXN WASL ROCK2 ARHGEF7 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY CHUK NFKBIA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 RELA MAPK8 CASP6 NFKB1 CASP9 CASP8 BCL2 CASP3 MAP3K5 BAG4 FADD DFFB DFFA TRAF1 CYCS TNF BIRC3 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY IFNG MAPK1 PINX1 SMG6 PARP2 DKC1 TERF2IP WRN ACD RBBP4 PTGES3 ZNFX1 BLM HNRNPC NBN IRF-1 ATM CCND1 MRE11A HUS1 FOS RAD50 RAD1 NCL RAD9A NR2F2 IFNAR2 TERF2 SMG5 JUN HDAC1 HEL2 SIN3B SP1 SIN3A MAX SAP30 WT1 MYC SP3 SAP18 RBBP7 TERT MXD1 MAPK3 TGFB1 IL2 NFKB1 UBE3A MTOR RPS6KB1 EGF CDKN1B HDAC2 TNKS XRCC5 TERF1 EGFR BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY CREB1 NFKB1 PIK3CA MAPK1 MAP2K3 MAP2K2 MAPK14 MAP3K1 SP1 RB1 PIK3R1 RELA MAP2K6 MAP2K1 MAPK3 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 PIAS1 MDM2 UBE2I SUMO1 HDAC1 RAN RANBP2 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY LAMB1 LAMC1 NFE2L2 DNAJB1 HEL-S-89n DNAJB6 APLP1 RPSA PRNP GFAP BCL2 LAMA1 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKAP TRAF3 TNFAIP3 MAP3K1 IKBKB CHUK NFKBIA TRAF2 TANK TRAF1 TNFRSF1B RIPK1 IKBKG MAP3K14 RELA PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY CXCL12 HEL-S-15 CD3G PAK1 CD3E MAPKAP1 CD3D MLST8 RICTOR BLK YES1 RALB SRC c-fgr CDC42 PAG1 RGS1 ITGAV RHOB VPS4B CRK VPS4A SSH1 FOXO1 UBQLN1 STAT5B CSK PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 STAT2 PIK3CD PIK3R3 PIK3R2 ITGA4 ITGA2 BAD STAT3 ITGA1 LYN ITGA7 ITGA6 PIK3R1 FYN PRKCZ DKFZp686L0365 PTEN RAC1 PDPK1 GNAZ GNAI3 GNAI1 PTPN11 PTPRC MTOR PIK3CA PTK2B ITCH LCK ARHA GNAO1 ITGB1 PLCB3 VAV1 STAT1 PLCB1 CXCR4 PLCB2 HGS LIMK1 ADRBK1 PXN MMP9 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA HEL-S-44 HRAS GHR FOXO3A GH1 IGF1 IGF1R BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY ABI2 PIR ACTA1 WASF3 WASF2 NCKAP1 WASF1 NTRK1 NCK1 RAC1 HEL-S-276 WASL BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 NR1I3 PTGS2 PTGS1 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY NOTCH1 MAPK1 JUN CSNK2A1 NEDD4 HDAC1 APC GSK3B MYC MAP3K7 TLE5 PSEN1 NLK MAPK3 DVL1 CREBBP CTBP1 FRAT1 AXIN1 FZD1 CSNK1A1 DTX1 FBXW11 NKD1 DKK2 MAP3K7IP1 PSENEN HNF1A CCND1 FOS LRP6 APH1B WIF1 ADAM10 WNT1 PPP2R5D RBPJ DKK1 NR1C2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY CXCL12 NFKB1 PIK3CA PTK2B MAPK1 HRAS PIK3C2G RAF1 CXCR4 PIK3R1 RELA PRKCB MAP2K1 PRKCA PLCG1 MAPK3 CRK BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY CNR1 PLD2 FAAH CNR2 BAAT PLD3 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY NRAS NCOR1 CEBPA IQGAP1 ELANE ADA CEBPB LEF1 CEBPD NLK HES1 CREBBP KITLG KIT CDKN2A SLC25A3 CCND1 LECT2 YEATS4 RAG2 CD34 PAX5 MAF SND1 ADORA2B TFEC SPI1 PRTN3 MAD1L1 HEL-S-11 H2AZ1 ZFHX3 GSTM1 UBE2I ATP2B1 LYZ COPA HIPK2 SKI MYF6 PPP3CA PIM1 CCNB1 CBX4 CSF1R ETS2 SP1 SIN3A MYC ZFPM1 GATA1 MAP3K7 CDK6 GATA3 MYB CASP6 PTGS2 MAP3K7IP1 MPO HRAS BCL2 COL1A2 CLTA CDKN1A CDKN1B WNT1 MYOD1 TRIM28 EP300 BIRC3 BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RING1 EED COMMD3-BMI1 EZH1 EZH2 CBX4 HDAC1 HDAC2 RBBP4 RBBP7 YY1 BMI1 SUZ12 PHC1 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNAI1 GNA14 MAPK8 PAK1 GNA15 GNA11 MAPK1 JUN ARHA MAPK14 GNAO1 FOS S1PR2 IRS1 GNA13 MAPK3 RAC1 GNAZ GNAI3 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY IL4 IL3 IL6 IL5 PDGFA IFNG CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 IL1A IL7 CXCL8 TNF IL10 IFNA1 IFNB1 IL15 IL13 IL11 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PLCB1 PIK3R1 PIK3CA PRKCB PRKCA PLCG1 VAV1 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY PIK3CA MAPK1 BAD ADCY1 HRAS GRB2 SOS1 RAF1 RPS6KA1 SHC1 IRS1 PIK3R1 MAP2K1 PRKAR1B PRKAR1A MAPK3 PRKACG IGF1R PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PIAS2 CD3G IL18RAP CD3E CD3D PPP3R1 IFNG MAPK9 TBX21 JUN STAT3 PRF1 TGFB1 CREBBP IRF-1 MAPK8 IL2 STAT4 IL18R1 IL2RA CD80 FOS ETV5 IL13 PPP3CA IL18 BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB NFYC SP1 BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY EPYC KERA DCN PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGB4 ITGA4 ITGAE ITGB8 ITGA2 ITGB7 ITGB6 ITGA1 ITGB1 ITGA2B ITGAM ITGB3 ITGAX ITGA7 ITGA6 ITGAV PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY CREB1 IL5 KAT2B NR1i1 KAT2A RBL1 TFDP1 NCOR1 RUNX1 RBBP4 E2F4 CEBPB E2F5 FOXO4 NR3C1 CREBBP FOXO1 CDK2 HNF4A FOS CBFB ATF3 SKI RUNX2 NCOA1 GSC JUN CITED1 HDAC1 MED15 SIN3B SP1 SIN3A SNIP1 MAX TGIF1 SAP30 MYC TGIF2 FOXH1 SP3 RUNX3 DLX1 FOXG1 SAP18 RBBP7 CDKN2B GATA3 SKIL DCP1A SMAD2 SMAD4 FOXO3A CTBP1 LAMC1 TCF3 NKX2-5 ATF2 MEF2C COL1A2 CDKN1A HDAC2 CDK4 MYOD1 EP300 IL10 IFNB1 IRF7 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 MAPK8 TAF1 RPA1 GADD45A ATM CDKN1A BAX ABCB1 FHL2 DNAJB1 MDM2 NFKBIB HIF1A NQO1 EP300 BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 TNFSF6 CD40LG HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNB1 CSNK1G3 CSNK1D HDAC1 SIN3B CSNK1G2 SIN3A CSNK1G1 SAP30 GSK3B RBBP4 SAP18 RBBP7 IFT172 GLI3 KIF3A RAB23 SUFU MAP2K1 DKFZp686L0365 SPOP hCG_2014051 CREBBP MTSS1 GNAZ GNAI3 GNAI1 CSNK1A1 PIAS1 SHH FBXW11 PTCH1 GNAO1 FOXA2 HDAC2 GNG2 SMO PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL4 TSG101 IL6 CREB1 IL5 IFNG SMARCD1 MAPK1 SMARCC1 SMARCC2 SGK1 KRT5 TBP GSK3B MAPK11 KRT14 BAX CSF2 POU2F1 NR3C1 CREBBP PRKACG IRF-1 SELE STAT5B NR1I3 FOS POMC SPI1 SUMO2 NFATC1 PRL BGLAP NCOA1 SFN MAPK9 TBX21 JUN HDAC1 MAPK14 MAPK10 SMARCA4 GATA3 MDM2 RELA MAPK3 CSN2 KMT5B POU1F1 FKBP4 FKBP5 MAPK8 CGA IL2 PCK2 NFKB1 CDK5 PBX1 CDK5R1 STAT1 CDKN1A HDAC2 CXCL8 PPP5C EP300 EGR1 AFP IL13 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY CDKN2A CDC2 DHFR TFDP1 CDK2 ATM CCND1 HDAC1 CCNE1 GSK3B RB1 CDKN1A CDKN1B CDKN2B CDK6 CDK4 ATR SMAD4 TGFB1 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY IQGAP3 HEL-S-15 HEL-S-47e PAK1 MAPK9 MAP2K3 JUN ARPC4 STAT3 ARPC5 MAP2K4 MAPK14 MAP3K1 BAIAP2 ARPC2 ARPC3 IQGAP1 MAP2K6 WASF1 CTNNA1 ARHGAP5 PIP5K1C RAC1 CRK ABI2 MAPK8 NCF2 STM7 CYBB CYBA MAP3K11 NOXA1 ATF2 BRK1 WASF2 PLCB2 LIMK1 CYFIP2 NCKAP1 ARPC1B ACTR3 ACTR2 PIP5K1A BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY MAPK1 PRKCE MAP2K3 JUN MAPK13 ETS2 MAP2K4 MAPK14 IKBKB MAP3K1 SP1 CHUK NFKBIA TRAF2 CEBPA PPP2CA TNFRSF1A RIPK1 TNFSF6 MAP3K14 RELA MAP2K6 MAP2K1 MAPK3 MAPK8 NFKB1 HOXA7 HRAS PRKCH BCL2 MAP3K5 EGF FOS PRKCQ RAF1 TNFRSF1B TNF PRKCB PRKCA EGFR BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY ARHA LPAR1 LPAR2 LPAR3 PRKACG PRKAG1 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY HDAC3 GTF2A1 MED1 HDAC5 PPARGC1A CCND1 HDAC1 MEF2C TBP H3C15 CARM1 PELP1 HDAC2 BRCA1 SRA1 PHB2 SPEN EP300 CREBBP NR0B1 NCOR2 GRIP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY CREB1 NRAS RPS6KA5 MAPK1 MAP2K3 BRAF TRPV1 MAPK14 MAP2K6 RAP1A MAP2K1 MAPK3 CDK5 NTF3 RIT1 CDK5R1 HRAS RIT2 MEF2C FOS RAF1 RPS6KA1 MAPKAPK2 MAP2K5 MAPK7 MAP3K2 EGR1 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY CD3G TYK2 CD3E IFNG STAT4 CD3D CXCR3 CCR5 IL12RB1 CD2 NOS2 PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY IL6 ADCY9 PRKCE ADCY3 ADCY1 LPAR4 ADCY8 ADCY6 ADCY5 GSK3B SRC CRK FOS TRIP6 GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN PRKD1 NFKBIA LYN PIK3R1 RELA PLCG1 RAC1 HBEGF GNAZ GNAI3 GNAI1 GNA14 GNA15 NFKB1 GNA11 ADRA1B PTK2B ARHA HRAS LPAR1 GNAO1 CASP3 MMP2 LPAR2 PLCB3 LPAR3 CXCL8 NHERF2 PXN TIAM1 EGFR MMP9 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP3K6 MAP3K10 MAP3K7IP1 MAP2K3 GADD45B GADD45A ATM GADD45G MAPK14 MAP3K1 TXN MAP3K5 TAOK3 TRAF2 TAOK1 TAOK2 MAPK11 TRAF6 MAP3K7 MAP2K6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY GUCY1A2 TRPC5 GUCY1B1 TRPC4 TRPV4 KCNQ2 KCNQ3 TRPC3 KCNQ5 ADCY1 GNAS BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2AK2 EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 EIF2AK4 EIF2B5 GSK3B BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY CASP6 BAK1 DIABLO CASP9 CASP8 BCL2 CASP3 DFFB DFFA BAX AIFM1 BIRC2 BIRC3 BIK APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS IFNG PRKCE MAPK1 MAPK11 CISH STAT5B CDK2 IKZF3 FOS IRS1 PPP2R5D PRKCB SOCS3 SOCS1 MAPK9 JUN SYK STAT3 MAPK14 MYC SHC1 PIK3R1 FYN IL2RG MAP2K1 MAPK3 JAK3 JAK1 PTPN11 GAB2 MAPK8 IL2 PIK3CA PTK2B LCK MAP2K2 ARHA IL2RA HRAS IL2RB BCL2 GRB2 SOS1 STAT1 RAF1 MAPKAPK2 STAM2 SOCS2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY mkl1 HEL-S-15 SCAI HEL70 RDX MAPK12 PLD2 CIT PKN2 LIMK2 MAP2K3 JUN MAP2K4 PARD6A ACTA1 PRKCZ CDC42 MAP2K6 MYL2 PIP5K1C EZR PTEN TLN1 MAPK8 F2RL2 PKN1 STM7 HEL114 ARHA ATF2 ITGB1 SLC9A3 FOS CYR61 CDKN1B SH3GL2 LIMK1 ROCK1 ROCK2 PIP5K1A PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY CSTF1 UBE2D3 BARD1 EWSR1 CCNE1 RAD51 RBBP8 NBN FANCL CDK2 FANCA ATM MRE11A PRKDC FANCE FANCG NPM1 FANCF RAD50 FANCD2 PCNA BRCA1 ATR XRCC5 TOPBP1 UBE2L3 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY FANCF FANCD2 BRCA1 BARD1 FANCA FANCE FANCG BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY PPP3CC CALM1 MAPK1 CTF1 HEL-S-99n HAND2 MAPK14 NFATC4 CAMK4 HAND1 GSK3B ACTA1 PIK3R1 NPPA MAP2K1 PRKAR1B MAPK3 MYH2 PRKAR1A CREBBP HBEGF PRKACG IGF1 CSNK1A1 MAPK8 RPS6KB1 GATA4 PIK3CA NKX2-5 HRAS NFATC3 EDN1 MEF2C RAF1 FGF2 CAMK1 CAMK1G NFATC2 NFATC1 F2 PPP3CA PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY MAPK1 EPHB2 ITGA2 CAV2 TRAPPC4 SRC BAX CSF2 MAPK3 TGFB1 EZR MAPK8 KNG1 ARHA HRAS ITGB1 CASP3 MMP2 CASK TNFRSF13B LAMA1 LAMA3 SDC2 CXCL8 SDCBP NF1 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY TOP2A DFFB DFFA HMGB1 HMGB2 CASP3 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PTK2B PRKCB PRKCA PLCG1 P2RY2 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 MAP3K7 SPTAN1 MAPK8 LMNB2 CASP8 PRKDC CASP3 ARHGDIB BAG4 LMNA FADD RB1 DFFB DFFA PARP1 MADD TNF BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY RCC1 HCTP4 KPNA2 NUMA1 RAN RANBP1 AURKA KIF15 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY NGFR NGF HEL-S-47e BCL2L11 NTRK1 CHUK NSMCE3 OMG RTN4R BEX3 TRAF6 MAGEH1 IKBKG ZNF274 BEX1 RTN4 NDN SORT1 RHOB PSENEN APH1B FURIN RIPK2 MAPK9 ADAM17 BAD IRAK1 HEL2 IKBKB MAPK10 MYD88 SHC1 PIK3R1 PRKCZ PSEN1 RAC1 PRKCI APP CASP6 MAGED1 MAPK8 NTF4 NTF3 PIK3CA DIABLO CASP9 ARHA CASP3 SMPD2 MMP7 BDNF MMP3 PLG SQSTM1 CYCS BIRC2 BIRC3 APAF1 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAPK1 MAP2K3 MAP2K2 MAP2K4 IL1B MAP2K6 TNF ANTXR2 MAP2K1 ANTXR1 DEFA1B MAPK3 NLRP1 VCAM1 PGR IL18 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY CTNND1 ITGAE CSNK2A1 ITGB7 CSNK2A2 CSNK2B SRC IQGAP1 PIK3R1 VAV2 CDC42 JUP AFDN RAP1A CTNNA1 RAPGEF1 ARF6 PIP5K1C RAC1 KLHL20 CRK TJP1 PIK3CA ARHA CCND1 WASF2 CYFIP2 NCKAP1 TIAM1 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL4 IL1B IL6 IL5 HLA-DRB5 IL5RA HLA-DRB4 HLA-DRB3 CCL11 CCR3 HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY GPLD1 VTN SRC ITGAM ITGB3 ELANE ITGAV PLAUR TGFB1 RAC1 VLDLR CRK FPR1 KLK4 FPR2 PDGFD CTSG FPRL2 MMP12 CTRC FGA ITGB1 HEL-S-78p MMP3 PLG HGF DOCK1 NCL EGFR MMP9 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY STAT1 IFNG IFNGR1 IFNGR2 JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY ARF1 MAPK1 MAP2K3 BRAF NCK1 SRC ITGB3 FLT1 IQGAP1 MAPK11 CDC42 MAP2K6 KDR CTNNA1 ITGAV FBXW11 HSP90AB1 HEL114 MYOF FES PTPN6 PRKAB1 PRKCB PRKCA VTN VEGFA NEDD4 MAPK14 GRB10 PRKAG1 PIK3R1 FYN SHB MAP2K1 PLCG1 MAPK3 PDPK1 CBL PTPN11 PRKAA1 NCK2 PIK3CA PRKAA2 PTK2B MAP2K2 ARHA GRB2 RAF1 MAPKAPK2 SH2D2A CAMKK2 HGS ROCK1 PXN PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY KALRN ARF1 PLD2 MAPK1 ARHA RAB11FIP3 ARF6 PLAUR MAPK3 RAC1 TIAM1 RAB11A PIP5K1A BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY NRG1 ERBB3 UBE2D1 EGF EGFR BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG KIT RPS6KA1 CREB1 EP300 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY RARA RXRA THRA MAP2K1 ZBTB16 MAPK14 MAP3K1 EGF EGFR NR1A2 NCOR2 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY AXIN1 FZD1 EIF2AK2 NFKB1 PIK3CA CCND1 LBP APC GSK3B GJA1 PPP2CA MYD88 WNT1 PIK3R1 RELA LEF1 DVL1 PDPK1 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY AXIN1 FZD1 MED1 HDAC1 LDB1 APC PITX2 GSK3B WNT1 TRRAP KAT5 LEF1 EP300 CREBBP DVL1 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CD58 CD34 CSF3 CXCL8 CD8A BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY PPP3CC CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 MAP3K1 NFKBIA RELA MAP2K6 MAP2K1 MAPK3 RAC1 FPR1 GNA15 NFKB1 NCF2 MAP2K2 HRAS NFATC3 PIK3C2G RAF1 PLCB1 CAMK1 CAMK1G NFATC2 NFATC1 PPP3CA BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY AXIN1 BTRC FZD1 NOTCH1 WNT1 RBPJ ADAM17 HNF1A PSEN1 DVL1 APC GSK3B BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY IL3 CSF2 IL5 CCL5 HLA-DRB5 HLA-DRB4 HLA-DRB3 CCL11 CCR3 HLA-DRB1 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY VEGFB FLT1 VEGFA KDR NRP1 FLT4 VEGFC NRP2 VEGFD BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY RETN RXRA LPL PPARG TNF NR3C1 HSD11B1 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY CCNB1 CDC2 MAPK1 ADCY1 HRAS MYT1 CAP1 PAQR7 ACTA1 RPS6KA1 PAQR5 PIN1 PRKAR1B PRKAR1A MAPK3 PRKACG PGR BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PAK1 CDK5 NCF2 RPS6KB1 PIK3CA sm-M20 CDK5R1 MAP3K1 CHN1 RALBP1 VAV1 LIMK1 PIK3R1 TRIO PDGFRA WASF1 MYL2 RAC1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY SDC1 MAPK1 COL1A1 COL16A1 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 MAPK3 TGFB1 COL9A2 COL17A1 LAMA5 CASK MMP7 COL3A1 COL1A2 hEMMPRIN HPSE HGF PPIB SDCBP CCL5 COL4A1 COL4A4 COL4A3 COL4A6 MMP9 COL4A5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY PRF1 CASP10 PARP1 JUN CASP9 CASP8 CASP3 ARHGAP5 ARHGDIB APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY SOCS3 IL6 TNFSF11 JUN STAT3 MAP2K4 MAPK14 MYC MAPK11 PIK3R1 MAP2K6 CEBPB CEBPD MCL1 RAC1 TIMP1 JAK1 FOXO1 IL6ST IRF-1 IL6R PTPN11 GAB2 PIAS1 TYK2 JUNB PIK3CA LBP GRB2 SOS1 FOS VAV1 BCL2L1 STAT1 CRP HEL-S-125m A2M LMO4 PTPRE BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY LRP8 DAB1 RELN CDK5 FYN CDK5R1 VLDLR PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY IL6 TH CCNA2 CREB1 IFNG MAPK1 DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE JUNB JUND CCND1 FOS CBFB ARG1 HRK ACHE PRKCA ATF3 CSRP2 JDP2 COL24A1 NOS2 NF1 HBG2 SOCS3 INS MAPK9 JUN PPARGC1A GADD45A MAPK14 PDGFRA MAPK3 MAPK8 DUSP5 IL23A ATF2 BCL2 MMP2 SERPINB5 BCL2L1 RB1 DDIT3 BRCA1 CDK4 CXCL8 EP300 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY MAP2 PPP2CA NUP85 AKAP9 PCNT PKN1 CDC2 PRKCE ARHA PRKACG PRKAG1 PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY PIM1 MEF2D SFN KPNA2 PPP3R1 MAPK9 PRKCE CSNK2A1 BAD MAPK14 CAMK4 HEL2 MAP3K1 GSK3B PRKCZ MAPK3 CREBBP HEL-S-93 CSNK1A1 MAPK8 FKBP1A YWHAQ HEL-S-1 PRKCH BCL2 CASP3 YWHAG NFATC3 AKAP5 CHP1 BCL2L1 PRKCQ EP300 PRKCB NFATC2 RAN PRKCA NFATC1 RCAN1 CABIN1 NUP214 PPP3CA MAP3K8 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNB1 PIK3R1 CHRNG TNFSF6 MUSK PIK3CA PTK2B RAPSN TERT BAD FOXO3A PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY IL4 ADAM12 NOTCH1 NOTCH3 MYCBP NOTCH4 HDAC1 DLL3 DLL4 DNER NCOR1 JAG2 MYC MIB1 MFAP5 FBXW7 MFAP2 CNTN1 LNX1 RBBP8 GATA3 PSEN1 CTBP1 CBL DTX1 ENO1 ITCH NOTCH2 PSENEN CCND1 SKP1 APH1B CDKN1A ADAM10 KDM1A MAML2 MAML1 RBPJ NUMB FURIN YY1 EP300 SPEN RAB11A NCOR2 PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY MAPK1 PPP1R15A GSK3B CHRDL1 MAP3K7 SOSTDC1 CER1 AHSG FST RGMB SMAD4 BMP6 RGMA GREM1 SMURF2 SMURF1 CTDSP1 CTDSP2 CTDSPL BMPR2 MAP3K7IP1 ZFYVE16 DKFZp781O1323 BAMBI SMAD1 NOG BMP7 BMP4 BMP2 BMPR1A SKI NUP214 SMAD9 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY CD3G CD3E NRAS CD3D IFNG PRKCE MAPK1 BRAF TNFRSF9 CD8B JUNB STAT4 NFATC3 FOS PRKCB NFATC2 PRKCA NFATC1 PPP3CA IFNAR2 IFNAR1 PPP3R1 MAPK9 JUN HLA-A B2M PRF1 IL2RG FOSL1 TNFSF6 MAP2K1 MAPK3 IFNA5 IFNA4 IFNA7 IFNA6 IFNA2 IFNA8 TNFRSF4 MAPK8 IL2 IFNA14 IFNA16 IFNA17 TNFRSF18 IFNA10 MAP2K2 IFNA21 IL2RA HRAS EGR4 IL2RB PRKCQ RAF1 TNF CD8A EGR1 IFNA1 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROC F2R TFPI FGA F10 SERPINC1 F3 PROS1 F5 F7 F2 HEL-S-78p PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY SOCS3 PRL INS LEPR PRLR LEP CSF1R CSF1 STAT3 LAT BLK YES1 SRC ITGB3 LYN CDH2 c-fgr SHC1 PIK3R1 FYN PTPN1 INSR FER TRPV6 CSN2 CRK STAT5B TYK2 DOK1 PIK3CA LCK ARHA CSK SPRY2 ITGA2B TXN GRB2 YBX1 EGF NOX4 FCGR2A IRS1 EGFR BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL4 EPO IL3 IL6 IL2 IL5 IL9 CSF1 CSF3 CSF2 IL7 CXCL8 CD8A IL11 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY IL4 IL3 IL5 IFNG EGR2 TBX21 JUN PPARG CD40LG CSF2 CTLA4 FOXP3 GATA3 PTPN1 FOSL1 TNFSF6 POU2F1 IL2 PTGS2 JUNB ITCH IL2RA EGR4 CASP3 NFATC3 FOS DGKA MAF SLC3A2 BATF3 PRKCQ IKZF1 PTPRK GBP3 RNF128 CDK4 CXCL8 TNF EGR1 NFATC2 NFATC1 IRF4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EIF2AK2 PIK3CD KPNA2 VEGFA PIK3R3 INS PIK3R2 CSF1R CSF1 STAT3 ITGA1 SRC SHC1 PIK3R1 PTPN1 INSR KDR CREBBP JAK3 JAK1 RAB4A PIAS1 STAT5B PIK3CA ITGB1 GRB2 SOS1 EGF STAT1 LMAN1 HGF ATR EGFR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY PELP1 MAPK1 EP300 MAPK3 CREBBP BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY PTPRC CD40 CR2 CR1 FCGR2B HLA-DRB5 HLA-DRB4 CD80 HLA-DRB3 HLA-DRB1 BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY ACTA1 SPTBN1 PCLO GRIN1 DLG2 DLG4 GUK1 NRXN3 CASK NCAM1 SPTAN1 ADD1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAPK8 MAPK1 MAP2K2 HNF1A ARHA MAP4K2 HRAS MAP3K1 RAF1 ACTA1 LIMK1 CDC42 MAP2K1 ROCK1 MAPK3 RAC1 MAL BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY STAT1 SOCS3 STAT5B TYK2 STAT3 JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 hCG_2014051 PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY IL1A SELL PECAM1 ICAM2 CXCL8 ITGA4 ITGB1 VCAM1 CD34 MADCAM1 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SH2B3 TEC SOCS3 BTK MAPK14 PLCG2 LYN SHC1 PIK3R1 VAV2 RAP1A EPOR CRKL RAPGEF1 PLCG1 CBL EPO PTPN11 MAPK8 STAT5B NFKB1 TRPC6 HRAS BCL2 GRB2 SOS1 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY DYRK1A SHH DYRK1B PTCH1 GLI3 PRKAR1B SUFU SMO PRKAR1A PRKACG GSK3B PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 RPL5 DYRK2 KAT2B SETD8 SETD7 TP53AIP1 RASSF1 CSNK1G3 DKFZp781B1423 CSNK1D PPP1R13L KAT8 CSNK1G2 RPL23 CSNK1G1 FBXO11 GSK3B PPM1D RFWD2 PTPA SMYD2 CCNG1 E4F1 KAT5 PIN1 CHEK1 hCG_2014051 CREBBP CSNK1A1 CDKN2A CDK2 NEDD8 ATM UBE2D1 CHEK2 ATR HIPK2 MAPK9 RPL11 MAPK14 PPP2CA HUWE1 MDM2 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY PTPN11 SLC2A4 MAPK8 PIK3CA JUN CSNK2A1 HRAS GRB2 SOS1 FOS RAF1 SHC1 IRS1 PIK3R1 INSR MAP2K1 MAPK3 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY PIK3CD PIK3R3 PIK3R2 MAPK9 SYK BTK MAPK14 IKBKB MAP3K1 CHUK MAPK10 SRC MAPK11 FAIM2 PIK3R1 RIPK1 IKBKG TNFSF6 MAP2K6 SMPD1 EZR PDPK1 CASP10 MAPK8 PIK3CA CASP8 CASP3 RFC1 FADD BIRC2 BIRC3 CLTC BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY MAN1A2 MAN1A1 MAN2C1 SKP1 EDEM1 FBXO2 SEC61A1 GANAB CANX UBE2I GCS1 RBX1 UGGT1 UBA2 SAE1 MAN2A2 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EEF2K EIF3A EIF4E EIF1AX EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF5 EEF2 EIF4A1 EIF6 EIF4G1 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY DAPP1 BASH MAPK1 BTK MAP3K1 CHUK POU2F2 PLCG2 TRAF6 IKBKG VAV2 PAG1 CD19 SH3BP5 CARD11 CD72 IBTK CD22 CSK FOS PTPN6 NFATC1 PPP3CA PPP3CC BCL10 CSNK2A1 JUN SYK MAPK14 IKBKB CD79B NFKBIA CD79A LYN SHC1 CAMK2G MAP3K7 PIK3R1 NFKBIB RELA MAP2K1 MAPK3 PTEN RAC1 PDPK1 MAPK8 DOK1 NFKB1 PTPRC PIK3CA FCGR2B HRAS GRB2 SOS1 RAF1 BCL2A1 MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNB1 HEL70 NRAS GNAL NR3A2 SRC PELP1 MAPK11 SHC1 PIK3R1 HBEGF GNAZ GNAI3 IGF1R GNAI1 GNA14 STRN GNA15 GNA11 PIK3CA ARHA HRAS GNAO1 MMP2 GRB2 PLCB3 SOS1 PLCB1 PLCB2 GNA13 GNG2 ROCK2 MMP9 BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 WNT8A WNT8B DKK2 DKK1 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F2R F8 SERPING1 FGA KNG1 KLKB1 F10 PROS1 F5 HEL-S-78p PROC F9 F11 COL4A2 SERPINC1 COL4A1 COL4A4 F2 COL4A3 COL4A6 COL4A5 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY TGFBR1 VTN EDIL3 SDC1 ITGA4 ITGB8 FBN1 ITGB7 ITGB6 CYR61 PLAUR ITGAV VCAM1 MADCAM1 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY NFKB1 IFNG USH1C LIN7A TAX1BP3 IKBKB NFKBIA WT1 RB1 TNFRSF1A TNFRSF1B RELA IFNGR1 TNF IFNGR2 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY PECAM1 HEL114 CTNNA1 CSK ACTN2 ACTN1 LRRTM2 CTNNA3 CTNNA2 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 CDC34 FBXW7 TFDP1 CDK2 CCNE1 SKP1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY PRKCE HEL-S-44 GPX1 GABRA2 GABRA6 GABRA5 GABRA4 GABRA3 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY GNAI1 VEGFA PTGS2 MAPK1 ARHA GNAO1 SPHK1 ITGB3 S1PR1 PLCB2 ABCC1 KDR ITGAV PLCG1 MAPK3 RAC1 GNAZ GNAI3 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RCC1 RAN RANBP1 RANBP2 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 CDC34 TFDP1 CDK2 CCNE1 SKP1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY PPP3CC CALM1 JUN SYK BTK MAPK14 NFATC4 MAP3K1 CD79B CD79A LYN SHC1 MAP2K1 PLCG1 MAPK3 RAC1 MAPK8 HRAS NFATC3 GRB2 SOS1 FOS VAV1 RAF1 PRKCB NFATC2 PRKCA NFATC1 PPP3CA BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY CREB1 SHC1 PTK2B HRAS GRB2 SOS1 LAMTOR5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY CREB1 RPS6KA5 JUN CSNK2A1 ATF1 PPARGC1A CSNK2A2 MAPK14 CSNK2B RAB5A EIF4E MAPK11 CEBPB PTGS2 MAPKAPK3 ATF2 MEF2C RPS6KA4 GDI1 HEL-S-102 USF1 KRT19 DDIT3 MAPKAPK2 MAPKAPK5 EIF4EBP1 NOS2 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY CHRNA1 PAK1 PAK4 MUSK MAPK1 RAPSN JUN SP1 ACTA1 NRG1 CDC42 NRG2 NRG3 MAPK3 DVL1 RAC1 LAMA4 MAPK8 GIT2 CHRM1 ITGB1 LAMA3 DAG1 DMD AGRN EGFR BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY IL6 ITGA4 KNG1 HEL-S-62p ITGB1 C6 SELPLG SELP IL1A C7 CXCL8 TNF VCAM1 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY PLCB1 TUB CHRM1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY CREB1 MAPK1 JUN GRB10 NCK1 SRC SHC1 PIK3R1 RAP1A MAPK3 RAC1 CRK FRS2 PTPN11 MAPK8 DOK1 PIK3CA ARHA RET HRAS GRB2 SOS1 IRS1 GDNF PDLIM7 DOK4 DOK5 DOK6 GRB7 SHANK3 PXN PRKCA BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY PPP3CC CALM1 CREB1 JUN ADCY1 HRAS NFATC4 NFATC3 FOS RAF1 PRKCB MAP2K1 NFATC2 PRKAR1B PRKCA PRKAR1A PLCG1 MAPK3 NFATC1 PRKACG PPP3CA PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY ITGA4 SRC CD14 JAM2 ARF6 PRKAR1B MYH2 PRKAR1A RAC1 TLN1 CRK HEL-S-93 PTK2B ITGB1 opn THBS1 DOCK1 MDK IGSF8 CD81 PXN THBS2 ADAM28 VCAM1 AMICA1 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY CASP6 BAD CASP9 ATM BCL2 CASP3 STAT1 BAX PARP1 EIF2S1 PRKCB PRKCA TLN1 APAF1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY F2RL3 F2R PTGS1 MAPK1 SYK HRAS ITGB1 RAF1 PLCB1 PRKCB MAP2K1 PRKCA MAPK3 F2 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY CCNB1 VPS16 CDC2 PRKCB CSK GRB2 PRKCA CDC25B PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SLC11A2 SIRT1 POU5F1 ADORA2A VEGFA EIF3E FXN SP1 FLT1 EGLN2 KDR VHL CREBBP ELOC MMP14 HIF1AN EPO CITED2 HEL-S-68p ABCG2 TWIST1 EFNA1 BHLHB2 APEX1 EP300 EGLN1 EGLN3 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 MAP2K4 BLK YES1 SRC ITGB3 LYN c-fgr PIK3R1 FYN MAP3K7 PTPN13 RAC1 MAPK8 NCK2 FGA PIK3CA LCK ITGA2B HEL-S-78p CXCR4 TIAM1 PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY IL4 CD40 C4BPA MAPK9 FCAMR JUN TRAF3 CD40LG MAP2K4 MAPK14 MAP3K1 NFKBIA MAPK10 MYC TRAF2 MAPK11 TRAF6 MAP3K14 RELA JAK3 MAPK8 NFKB1 TNFAIP3 BCL2L1 TRAF1 BIRC2 BIRC3 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY MAPKAP1 NRAS MLST8 MAPK1 RICTOR BRAF RB1CC1 SGK1 CCNE1 PML EEF2 EEF2K FBXW11 CDK2 RPS6KA1 IRS1 TSC2 DDIT4 EIF4A1 PRKCA BNIP3 TSC1 RHEB PLD2 SFN PRR5 RRAGA PPARGC1A RRAGB RRAGD HEL2 IKBKB ULK2 ULK1 RRN3 POLDIP3 EIF4B EIF4E MAP2K1 MAPK3 RAC1 PDPK1 HEL-S-93 MTOR RPS6KB1 YWHAQ HEL-S-1 MAP2K2 ARHA HRAS YWHAG RPTOR RAF1 DEPTOR AKT1S1 YY1 CYCS EIF4EBP1 PXN BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY ME1 NCOA1 PDGFA MED1 RXRA LPL MAPK1 JUN PPARGC1A SP1 NFKBIA NCOR1 MYC HSD17B4 MRPL11 DUT PIK3R1 APOA2 FABP1 ACOX1 RELA EHHADH NR1C1 PRKAR1B MAPK3 PRKAR1A CREBBP PRKACG CITED2 STAT5B PTGS2 PIK3CA RB1 SRA1 NR0B2 TNF EP300 PRKCB NR1H3 PRKCA NOS2 NCOR2 BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C6 C7 C9 CFB CFP CFD HEL-S-62p C8A PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 GDF15 TP53AIP1 BCL2L11 CCNE2 NTRK1 PML RAD51 FASN MAPK11 BAX CASP2 ADA KAT5 BRCA2 CLCA2 FLOT2 PIN1 CHEK1 AEN CDC2 TUBA1A CDK2 TP73 PLK1 TP63 SERPINA1 S100A2 HEY2 CCNB1 SFN WWOX PLK3 YAP1 MAPK14 SP1 JAG2 WT1 MYC BIN1 GATA1 TP53I3 CDK6 MDM2 RELA RNF43 UBE4B HAGH FOXO3A PFDN5 FBXO45 GRAMD4 JAK1 HSF1 BBC3 DEDD D4S234E PLPP1 ITCH RB1 CDKN1A EP300 AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY AXIN1 NKD2 FZD5 PI4K2A GSK3A STM7 WNT3A CSNK1G1 APC GSK3B LRP6 PPP2R5A DVL1 DVL2 DVL3 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY SH2B3 TEC SOCS1 BAD STAT3 GRB10 GRAP2 GSK3B LYN SHC1 PIK3R1 SNAI2 FER EPOR CRKL MAP2K1 FOXO3A MAPK3 PTEN CREBBP PDPK1 MATK CBL KITLG EPO PTPN11 KIT MAPK8 PTPRO DOK1 PIK3C2B SPRED1 RPS6KB1 STAP1 SH2B2 PIK3CA MAP2K2 HRAS BCL2 GRB2 SOS1 VAV1 STAT1 RAF1 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY IL1B MST1R CCL2 CSF1 TNF PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EPN1 TSG101 UBE2D3 PIK3CD NRAS LRIG1 PIK3R3 PIK3R2 SYNJ1 SRC RAB5A SHC1 PIK3R1 CDC42 CBL PIK3CA UBE2D2 ZFYVE28 UBE2D1 HRAS CHMP3 SPRY2 AMPH GRB2 STAMBP SOS1 EGF RAF1 SH3GL2 HGS ITSN1 EGFR ARHGEF7 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY RPS6KA1 CREB1 SHC1 PIK3R1 MAPK7 PIK3CA MAPK1 HRAS NTRK1 GRB2 PLCG1 MAPK3 BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 UBA2 CTBP1 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY CTNND1 FGFR1 BGLAP PAK4 MAPK1 JUN FGF4 CAMK2A SRC CDH2 SHC1 PIK3R1 PLAUR PLCG1 MAPK3 PDPK1 CBL FRS2 SSH1 PTPN11 STAT5B PTK2B PIK3CA SPRY2 GRB2 FGF8 opn SOS1 FGF9 FOS FGF23 STAT1 FGF17 SDC2 FGF19 RPS6KA1 FGF18 FGFR4 FGFR3 FGFR2 FGF2 HGF FGF6 NCAM1 MMP9 RUNX2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY CHUK NFKBIA TRADD TRAF2 RIPK1 MAP3K14 RELA TNFSF10 SPTAN1 CASP10 CASP6 NFKB1 CASP9 CASP8 BCL2 CASP3 LMNA FADD DFFB DFFA TNFRSF25 GAS2 BIRC2 BIRC3 APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY NDRG2 GTF2H2 MXD4 CREB1 NFYA RBL1 NFYB NFYC TBP PTPA CEBPA IRF8 CEBPD GIG8 CCND1 SPI1 TSC2 DKK1 DNTT HDAC3 GADD45A HDAC1 SP1 MAX MYC ITGA6 CDKN2B SMAD2 SMAD4 FOXO3A ITGB4 ERBB2 BCL2 ITGB1 COL1A2 CDKN1A DDIT3 CDKN1B BRCA1 GFI1 CLU FTH1 EP300 SFRP1 CCL5 TMEFF2 CSDE1 TMEM126A ALDH9A1 S100A7 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CCNB1 CDKN2A CDK7 CCNH CDC2 RBL1 TFDP1 CDK2 CDKN2D CCND1 CCNE1 RB1 CDKN1A CDKN1B CCND2 CDKN2B CDK6 CDK4 CCND3 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 SH3GLB2 PDGFRA CSF1R PRKCB GRB2 PRKCA EGF EGFR CBL BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY TGFBR1 TGFBR2 NFKB1 MAP2K3 MAPK14 IKBKB CHUK NFKBIA IL1B MAPK11 MYD88 MAP3K7 CXCL8 MAP3K14 RELA MAP2K6 TNF SMAD4 EP300 CREBBP NR3C1 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY NPNT NID1 CSPG4 COL2A1 COL6A1 COL11A2 JAM2 COL5A2 ITGAV PLAUR FGA HEL-S-78p TGFBI IGSF8 CD81 THBS2 VCAM1 VTN VEGFA ITGA4 FBN1 ITGA2 COL1A1 ITGA1 ITGA7 ITGA6 CD14 COL18A1 F13A1 LAMA5 LAMA4 LAMC2 LAMC1 ITGB1 opn LAMB3 COL3A1 LAMA1 LAMB2 COL1A2 LAMA3 LAMB1 TNC THBS1 MDK COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY IL4 IL5 GATA3 MAP2K3 PRKAR1B NFATC2 MAPK14 PRKAR1A NFATC1 PRKACG IL13 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY NFKB1 PIK3CA BAD CASP9 ARHA HRAS CHUK RALBP1 RAF1 PIK3R1 CDC42 RELA MAP2K1 FOXO4 MAPK3 RAC1 RALA BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY PTPN11 MAPK8 PIK3CA JUN CSNK2A1 HRAS GRB2 SOS1 FOS RAF1 SHC1 IRS1 PIK3R1 MAP2K1 MAPK3 IGF1 IGF1R BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY CALM1 MAPK8 PAK1 MAPK1 PTK2B MAP2K3 JUN MAP2K2 HRAS MAP2K4 MAPK14 MAP3K1 GRB2 SOS1 RAF1 SHC1 PRKCB CRKL MAP2K1 PRKCA PLCG1 MAPK3 RAC1 PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY MED1 KDM3A TMF1 TGFB1I1 UBA3 ZMIZ1 PATZ1 APPL1 TGIF1 SVIL KDM4C PELP1 NCOA6 CARM1 PA2G4 LATS2 TMPRSS2 ZNF318 KLK3 CDK6 SNURF CMTM2 FHL2 FKBP4 CDKN2A PIAS1 CTDSP1 CTDSP2 VAV3 TCF4 UBE3A PTK2B CASP8 CCND1 PRKDC PAWR KDM1A BRCA1 CCND3 NKX3-1 UBE2I XRCC5 RANBP9 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY CALM1 MAPK8 PAK1 MAPK1 PTK2B JUN MAP2K2 HRAS ATF2 MAP2K4 MAP3K1 GRB2 SOS1 AGTR1 RAF1 SHC1 PRKCB MAP2K1 PRKCA MAPK3 RAC1 EGFR BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY CXCL12 CALM1 MAPK8 CCR5 PTK2B JUN MAPK14 FOS CXCR4 CCL2 PRKCB CCL4 PRKCA PLCG1 BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPO NFKB1 RELA GRIN1 HIF1A EPOR NFKBIA CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog PTCH2 DYRK1A IHH KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 GAS1 MED1 HEL2 DKFZp686L0365 DHH PTCH1 HHIP TCR%NETPATH%TCR TCR SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 HEL-S-93 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P HEL-S-281 NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN ELP3 PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 MAP2K1 BCR%NETPATH%BCR BCR FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 BASH PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 TEC BCL6 RPS6KB1 CDK2 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB RPS6 IL1%NETPATH%IL1 IL1 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 LYN MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B HEL-S-93 GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 STAT5B JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 NFKB1 NFKBIA IL5 IL2RB RAPGEF1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B HEL-S-93 GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS PIK3CA ITGA6 PLEC COL17A1 LAMA5 HEL-S-93 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 ARHA IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 MAPK8 LEPTIN%NETPATH%LEPTIN Leptin CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB MAPK8 TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 RING1 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG MAML3 NOTCH2 HDAC2 SRC NOTCH4 LEF1 PSEN2 DTX1 FURIN PIK3R1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 MAPK3 SPEN JAG2 SMAD1 STAT3 NFKB1 SNW1 TCF3 EGFR1%NETPATH%EGFR1 EGFR1 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-93 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 HNRNPR ENO1 ANTXR1 CRKL GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD TRIP6 ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C DKFZp686L0365 ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF BRCA1 XPO4 SUMO1 HNF4A MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 DKFZp686L0365 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF HEL-S-93 COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway MYO1E MYO1B MYO1C SLC6A8 ACTC1 MYO1A MYO15A MYO5B MYO5C CHRFAM7A MYO1F MYO1G SLC44A3 ACTB ACTG2 ACTG1 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB2 CHRNB1 CHRNB4 CHRNB3 MYH15 MYO7B MYO7A ACTA2 MYH1 ACTA1 SLC5A7 MYH2 MYH3 ACTBL2 MYO3B CTAGE4 MYO3A CTAGE9 MYH8 MYH9 MYH4 MYH6 CTAGE15 MYH7 CHRNA1 CHRNA3 CHRNA2 PLEKHH3 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 MYH10 MYH7B MYO10 MYO5A MYO9A MYO19 MYO16 MYO1D NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer FOXA1 ATF1 RB1 CRKL CCND1 CHEK2 MYC CHEK1 MAP2K1 SMARCC1 MAP2K2 SPINK1 SMARCC2 HGF TSC2 TSC1 CDC25B MSH6 MSH2 EIF4E1B ERG RAF1 FKBP5 BLM PRKDC PXN KLK3 RAP1A EIF4EBP1 BARD1 SMAD2 JUN PLK1 SMARCA4 CDC2 RHEB CDK4 SP1 NOXA1 CDK2 BCL2 MDM2 GRB2 ATM F13B ATR CDKN1A CDKN1B PTEN BRCA1 RPTOR CASP9 CASP8 CASP3 HRAS JAK1 MAP4K1 ACTL6B ACTL6A FOS ARID1A ETV4 ARID1B PIK3CA RAPGEF1 SOS1 CRK DOCK1 SMARCD1 SMARCD2 SMARCD3 HSD17B3 HSD17B4 HSD17B7 CYP17A1 CPN1 MAPK8 PAK1 HSD17B1 HSD17B2 MAPK1 PTK2B RICTOR MAPK3 CDKN2B HSD3B2 BAD STAT1 CDKN2A STAT3 HSD3B1 MRE11A PTPN11 MAPK14 MTOR RAD50 BAX SPRY2 SPRY1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260610%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY3 ADRA1D ADRB1 ADCY1 ADRB2 ADCY8 ADRA2C ADRA2B ADCY6 ADRA2A ADCY5 HEL-S-7a ADCY9 ANGIOGENESIS%WIKIPATHWAYS_20260610%WP1539%HOMO SAPIENS Angiogenesis PLCG1 MAPK14 FGFR2 PIK3CA PDGFRA MAPK1 SMAD1 CREBBP FLT1 ANGPT1 SRC FGF2 HIF1A MMP9 VEGFA KDR TIMP3 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260610%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 CYP1A1 CYP1B1 AKR1C2 AKR1C4 CYP3A4 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260610%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P CMA1 CTSG REN FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders FGFR3 FGFR2 CCND1 SLC34A3 KL GALNT3 PTH CDKN1A SLC34A1 DMP1 opn NFKB1 NFKB2 CYP27B1 CYP24A1 CYP11B2 FAM20C ALPL ORAI1 ENPP1 FGF23 ROS1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260610%WP5053%HOMO SAPIENS Development of ureteric derived collecting system ANOS1 ETV4 RARB FREM1 FREM2 BMPR1A CCND1 RET BMPR2 SIX1 HOXD11 CELSR1 GLI3 SPRY1 HOXA11 GRIP1 SHH SALL1 BMPER SIX2 GPC3 GDF11 TGFB1 EYA1 FST CRIM1 BMP7 DCN SMAD1 ETV5 PAX2 NR1B3 BMP5 BMP4 CTDNEP1 BMP2 FRAS1 GDNF SMO RARA SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260610%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling ATF1 EGR1 NR3C1 HTR4 HTR6 HTR7 CREB1 RPS6KA5 MAP2K1 MAPKAPK2 GNAS MAP2K2 MAPK1 MAPK3 RAP1A MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260610%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HES1 HIF1AN HIF1A VEGFA VEGFB VEGFC SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260610%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL6 CXCL9 IFITM1 CSF2 CXCL8 TRADD CXCL17 CXCL1 CXCL13 CXCL3 STAT1 CXCL2 TNF CXCL5 IFIT2 TBK1 AP1G1 DHX58 TRIM25 EP300 IL6R HAVCR2 IL10 IFNAR2 TRAF2 ACE2 IRF3 hEMMPRIN TRAF3 TRAF6 TRAF5 IRF7 TLR7 NUP98 IFNAR1 HDAC2 TANK IL8RB LARP1 CCL5 CCL4 CCL3 CCL2 RIPK1 FADD RAE1 TFAP2A IFNB1 CD160 STAT2 MX1 PPBP MAVS IL6 CXCL11 TP53I3 CXCL12 RIGI PF4 NFKB1 TGFB1 CASP8 JAK1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome HES1 TNF TRAF3 CXCL11 CXCL12 MROH2A UGT1A10 DGKD TRAF3IP1 NDUFA10 HJURP ERFE KLHL30 IL13RA1 GABARAPL2 HES6 MEF2C GABARAPL1 RPS6 EEF1A1 THAP4 RRAGA RRAGB RRAGD CALCA CALCRL TWIST2 AGAP1 PDGFA JUN GABARAP NEU4 OR6B3 MAP4 TRPM8 OR6B2 ABCA1 UBE2F MTERF4 RAB27A NFKBIA CALM1 COPS8 HAMP COPS9 SNED1 RTP5 ARF1 RNPEPL1 ITGB3 PRL ING5 GYS1 SEPT6 MAP1LC3A MAP1LC3C RAC1 KIF1A GAL3ST2 ILKAP BOK MYOG UGT1A1 AQP12B AQP12A ITPK1 DUSP28 ANO7 OTOS HEL-S-28 ARL4C MYOD1 IL1B DKFZp762B153 IRF8 USP40 AGXT ARF5 DTYMK CXCR4 NEDD8 ASCL1 ASB18 CENPA EGFR CYTH2 GBX2 PPP1R7 GPC1 SH3BP4 UGT1A4 SPP2 UGT1A3 D2HGDH PRLH DISC1 UGT1A9 UGT1A8 ANKMY1 CYTH1 UGT1A7 FARP2 SEPTIN2 PDX1 SEPTIN4 PER2 MLPH CAPN10 ACKR3 PDCD1 RAB17 RAMP1 ASB1 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP5171%HOMO SAPIENS Leukotriene metabolic pathway ABCC1 ALOX5 CYP4F3 ALOX5AP DPEP2 LTC4S PTGR1 DECR2 DECR1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260610%WP3947%HOMO SAPIENS Serotonin and anxiety PRKCB FMR1 PLEK HTR1A HTR2A TRPV1 ADRA1A POMC PPP3CA ARC EEF2K CRH PLCD4 FOS PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer PIK3CA GSK3B MAPKAP1 PIK3R3 PIK3R2 FOXO4 PIK3R1 TSC2 FOXO1 NRAS RB1CC1 GRB10 RICTOR MLST8 FOXO3A TFEB BAD ULK1 EIF4EBP1 MTOR RHEB CDKN1B PTEN RPTOR HRAS PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260610%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CLRN3 CDH17 SPRR1B SPRR3 ST6GALNAC1 HEL-S-116 GPR87 HEL136 KRT20 CST6 AREG CYP3A7 LGALS4 SCEL TSPAN8 VSIG2 AGR3 FAM3D TNS4 KRT6C FAM83A KRT6A SERPINB3 BTNL8 FGFBP1 S100A2 REG4 KRT7 ANXA10 LYZ LEMD1 DHRS9 CEACAM6 SCCA2 PLA2G10 LY6D TFF3 TFF2 TFF1 VGLL1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260610%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification FGFR3 JAG2 NOTCH1 ITGA1 LPAR1 PLAT DLL3 DLL4 GJA5 MGP CALU SOX6 ALPL VEGFA MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260610%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 SIX4 CTDSP1 STRADB PTBP1 STK11 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260610%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP357%HOMO SAPIENS Fatty acid biosynthesis ACACB ACACA ACLY PC SCD FASN ECHDC1 ECHDC2 PECR ECHS1 MECR ACSS2 ACSL1 ACSL6 FACL4 ACSL5 ACSL3 DECR1 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260610%WP585%HOMO SAPIENS Interferon type I signaling RAPGEF1 CRK CREB1 RPS6KA5 STAT1 STAT3 PTPN11 MAPK14 MTOR EIF4A1 IFNAR2 IRS1 PIK3CD RPS6KA4 MAP2K3 PRMT1 TYK2 GAB2 VAV1 PIAS1 ZAP70 LCK IFNAR1 IRF9 CBL SOCS3 SOCS1 STAT4 FYN EIF4E EIF4B MAP2K6 MAP3K1 PTPRC RPS6KB1 REL PTPN6 STAT2 CRKL MAPKAP1 PIK3R2 PIK3R1 MLST8 RPS6 RAP1A EIF4EBP1 RPTOR JAK1 RAC1 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260610%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TBK1 IFNB1 TOMM70 IKBKE MAVS RIGI IRF3 TRAF3 TRAF6 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260610%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy MTOR ATG3 PIK3R4 ATG10 WIPI1 ZFYVE1 ATG12 DKFZp686F0183 ATG16L2 ATG16L1 ULK2 RB1CC1 ULK1 MAP1LC3A DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP707%HOMO SAPIENS DNA damage response CREB1 MRE11A RAD50 BAX RB1 CCND1 CHEK2 MYC CHEK1 H2AX HUS1B BBC3 TP53AIP1 PIDD1 CCND3 CCND2 SESN1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 PRKDC CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP CDC2 GADD45B GADD45A CDK4 TNFRSF10B PML GADD45G CDK2 RAD52 CDK6 MDM2 RAD51 CDK5 ATM CYCS RAD17 ATR CDKN1A RAD1 CDKN1B RAD9A BRCA1 CASP9 CASP8 CASP3 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260610%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity S100A9 MYD88 CCR3 PIK3CA HBEGF IL1B IL1R1 F2R NFKB1 HEL-S-134P IL18 F2 PLA2G7 TLR1 IRAK1 CCL2 MMP9 IFNG FCER1A NLRP3 TIMP1 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260610%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 RGS16 MYB KLF2 PRL CXCL12 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2876%HOMO SAPIENS Pregnane X receptor pathway UGT1A4 UGT1A3 CYP3A7 UGT1A1 UGT1A9 ABCC3 NCOA1 CYP3A4 ABCC2 ABCB1 NR1i2 CYP2C19 CYP4F12 CYP2C9 SLCO1B1 CYP2A6 RXRA FOXO1 CYP2B6 SRPX2 DNAJC7 PPARGC1A SULT2A1 SRC ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260610%WP5293%HOMO SAPIENS Acute myeloid leukemia PIK3CA SOS1 MAPK1 CSF2 MAPK3 ITGAM SPI1 FLT3 BAD ARAF MPO NR1C2 STAT3 IKBKB AKT3 PIM1 PIM2 IKBKG MTOR CHUK RUNX1 CCNA2 KIT SOS2 CEBPA CSF1R PIK3CD BCL2A1 CEBPE LEF1 RELA CD14 FCGR1A PER2 RUNX1T1 STAT5B TCF7L2 TCF7L1 JUP ZBTB16 IL3 RPS6KB2 RPS6KB1 CCND1 MYC MAP2K1 MAP2K2 PIK3R3 PIK3R2 PIK3R1 NRAS NFKB1 RAF1 EIF4EBP1 PML GRB2 HRAS RARA CREATINE PATHWAY%WIKIPATHWAYS_20260610%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260610%WP2261%HOMO SAPIENS Glioblastoma signaling PIK3CA MAPK1 MAPK3 CDKN2B EGFR ARAF CDKN2A AKT3 EP300 SPRY2 IRS1 PIK3CD MAP2K3 PDGFRA CBL SRC PIK3C2G BRCA2 MAP2K6 IGF1R PIK3C2B DKFZp781B1423 MAP2K4 PRKCB PLCG1 PRKCI FGFR2 PRKCH PDPK1 PRKCA PRKCQ RB1 PRKCZ ERBB3 CCND1 ERBB2 PLCG2 MAP2K5 CDKN2C MAP2K1 NF1 FGFR1 MAP2K2 PIK3R2 FOXO4 TSC2 PIK3R1 TSC1 FOXO1 CCND2 NRAS MSH6 FOXO3A RAF1 CCNE1 CDK4 CDK2 CDK6 MDM2 GRB2 ATM CDKN1A CDKN1B PTEN BRCA1 HRAS ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260610%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAPK8 MAFK CYP2E1 NFE2L2 SP1 MAP2K1 MAP2K2 MAFG MAFF TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260610%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis NR3C1 IL6 CEBPA IRS1 CREB1 MAPK8 RXRA CEBPB FOXO1 CEBPD INSR TWIST1 PPARGC1A SLC2A4 LEP PPARG LPIN1 PCK2 TNF PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4224%HOMO SAPIENS Purine metabolism and related disorders AMPD1 PFAS PAICS APRT DGUOK PNP IMPDH1 AOX1 XDH ADSS ADA ADSL TPMT HEL-S-70p RRM2B MOCOS FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260610%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins MAP2K4 RB1 MAPKAPK2 MAPK8 PAK1 APAF1 PRKDC TNF JUN FAF1 LMNB2 BCL2 ACTG1 CASP6 PS1TP5BP1 CASP10 CYCS ARHGDIB LMNA MAP3K7 SPTAN1 HEL-S-102 DFFB CASP9 DFFA CASP8 RIPK2 CASP3 ACTA1 IL1A TNFSF6 MAPKAPK3 FADD MAP3K1 NFX1 SMIM40 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260610%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 AIFM1 CASP2 CASP6 CYCS NFKB1 CASP9 CASP8 APAF1 CASP3 TNFSF6 RIPK1 MAP3K1 FADD TNFRSF1A ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260610%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL4 PLCB3 PLCB4 NR3C1 PRKAR1B ADCY3 MYL1 PRKAR1A MYL2 ADCY1 CREB1 MYL3 ADRB2 PLCB1 ADCY8 PLCB2 GNAS ADCY6 ADCY5 ADCY9 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260610%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 ITGA2 MADCAM1 ITGB7 SELE ITGB1 SELPLG VCAM1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260610%WP2369%HOMO SAPIENS Histone modifications KMT2E SETD4 SUV39H2 SETD5 SETD2 SET SETD3 KMT2A SETD8 SMYD5 SETD9 SUV39H1 KMT2C SETD6 KMT2B DOT1L SETD7 EHMT1 PRDM2 H3C15 SMYD2 SMYD1 KMT5B SMYD4 SMYD3 H3C8 H4C7 MLL2 H4C9 H3F3B SETDB1 KMT5C EED HIST1H4L SETD1B SETD1A SETDB2 SETMAR ASH1L AEBP2 SETBP1 EZH1 EZH2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260610%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAPK10 RPS6KA5 PRKAA1 SCD FASN IRS1 PIK3CD RPS6KA4 MAP2K3 CBL EIF4E MAP2K6 MAP3K1 RPS6KB1 IRS4 CBLC RPS6KA6 SESN3 RPS6KA2 RPS6KA1 PIK3R4 MAP3K8 MAP3K6 SLC16A2 MAP3K5 ABCG8 PRKAB2 MAP2K1 ABCG5 PRKAB1 MAP2K2 SHC2 SHC3 SHC1 LPL TSC2 PCK1 TSC1 G6PC1 MLXIPL MAP3K10 MAP3K13 MAP3K14 MAP3K11 RAF1 MAP3K12 GSK3A THRA HEL-S-31 PRKAG1 PRKAG2 PRKAG3 EIF4EBP1 FLOT1 FLOT2 CAP1 MAP4K2 EXOC7 MINK1 SREBF2 RHEB SLCO1C1 FBP1 PRKAA2 CYP7A1 INS NR1A2 MAPK9 MAPK7 MAPK6 MAPK4 MAP4K3 MAP3K2 PTPN1 HEL-S-42 NR1H3 RPTOR MAPK12 MAPK13 MAPK11 TRIP10 GYS1 HRAS MAP4K1 PIK3CA RAPGEF1 SOS1 CRK MAPK8 RXRA CYP2B6 MAPK1 RICTOR MAPK3 MAPK14 MTOR SOS2 RPS6KB2 PIK3C2G MAP2K4 PDPK1 CYP3A4 MAP2K5 GSK3B MAPKAP1 PIK3R3 PIK3R2 PIK3R1 FOXO1 INSR SLC2A4 MLST8 FOXO3A MAP3K7 CILIARY LANDSCAPE%WIKIPATHWAYS_20260610%WP4352%HOMO SAPIENS Ciliary landscape CAMK2A DYNLT2B USH1C HEL-S-47e RAB21 RMND5B IFT74 EXOSC4 DNPEP PGRMC2 RMND5A CBS STOM SNRPB2 UQCC NDUFA9 DYNC1H1 NDUFA5 RANBP9 LRPPRC MKLN1 WEE1 TTC8 PSMC6 ECHS1 GID4 MFAP1 APC RAB14 GLB1 PSMC4 VAPB ACSL3 XPNPEP3 GID8 RQCD1 DNCL1 YPEL5 CLUAP1 GLA H3F3B HDAC2 TFAP2A RB1 TRAF3IP1 MSH2 EXOC7 CALM1 COPS8 DYNC2I2 DGKE IFT172 UBE2D2 HEL113 RAC1 SMC4 DCAF7 PSMD7 MAEA APMAP CEP97 RAB2A IFT80 ARMC8 LZTFL1 DYNC1LI1 MYL6 IFT81 TIPRL ERF CD2BP2 ARL8B DDX5 POM121 PSMD12 CTBP2 INTU PSMD13 HTRA2 COPS7A IQGAP1 HEL-S-296 IQGAP3 CDH23 DVL3 NUP88 CDR2 AAR2 CTSA BBS2 NEK8 TFAP2B BBS1 TFAP2C UBE2H TFAP2D TFAP2E RHBDD2 EXOC6B CNOT10 FUZ BBIP1 LSM4 COPS4 IFT20 COPS6 IFT22 EHD3 COPS5 CNOT1 CREBBP WNK1 MKS1 LCN2 RANBP10 IFT27 DYNLRB2 IFT25 NEF3 DOCK5 TTC26 GDI1 MCM7 ZMYND19 MCM9 MCM10 MYL6B RPGR IFT52 NEFL BBS9 CEP170 TMED1 BBS7 IFT57 DFNB31 CEP290 NINL BBS5 SNAP29 BBS4 RAB8A NFKB1 IQCB1 EIF5B RBM14 NUDC CNOT6L EXOC8 NUP133 DYNLT1 EIPR1 IFT140 DYNLT3 RAB3IL1 ARFGAP3 DYNLL2 IFT43 RABEP2 TBC1D4 NME8 MCM3 EXOC4 EXOC3 EXOC6 MCM5 MCM6 EXOC5 EFHC2 IFT46 MAPRE2 EXOC2 PAFAH1B1 MCM2 CCDC40 EXOC1 YAP1 IFT70B IFT70A RALB WDR26 HEL-S-91n HDAC1 SSNA1 ANKS3 VPS4A GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260610%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A PLCB1 HDAC10 FRMPD3 CRTC1 ABAT ADARB1 CDH2 PIG59 HEL-S-162eP SH3GL2 PDIA2 SLC6A13 SLC6A12 SLC6A11 GABRG3 GABRG1 STIM1 GRIA2 SLC1A1 SLC1A2 SLC1A3 EFNB2 SDCBP GRIA3 GRIA4 HOMER1 NETO2 GRIN2B GRIN3B GRIN3A DLG4 CPEB3 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK1 AP2A1 MAP2K1 SLC7A11 GRIK2 AP2A2 CABIN1 GABRR3 GRM3 GRM2 GABRR1 SUMO1 GRM6 GRM8 NPTN FFAR1 DLGAP3 SLC32A1 NRG1 C1QL3 C1QL2 PICK1 GLS2 NRXN3 PPP2CA CACNG8 NWD1 SNX27 GNA11 CACNG2 GABRE ATAD1 GABRQ GABRA2 GABRP MBD5 SLC12A5 GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SYVN1 LHFPL4 GRIN1 SNX14 ERBB4 DKFZp762B153 MAPK1 MAPK3 STAT1 STAT3 CREBBP SLC6A8 SRC PRKCA ARC ORAI1 GRIP1 HDAC1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP3995%HOMO SAPIENS Prion disease pathway TBP HEL-S-269 PAX5 POU2F2 BATF IRF4 RFX5 CREB1 FGFR1 RXRA MAPK1 NFKB1 MAPK3 MEF2C SPI1 STAT3 EP300 BCL2 CTCF CHD2 SMC3 CASP3 FYN HEL-S-125m HEL-S-89n CASP12 RAD21 NCAM1 PRNP NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260610%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway ATG3 PIK3R4 ATG10 PANK2 WIPI1 PLA2G6 WDR45 ATG12 DCAF17 DKFZp686F0183 SPTLC1 DEPTOR ATG16L1 ATG101 WIPI2 STK11 C19orf12 PRKAA1 ATG14 CP TSC2 COASY TSC1 FA2H AKT1S1 RB1CC1 ATG2A FTL MLST8 ULK1 ACACA MTOR RHEB RPTOR MAP1LC3A CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260610%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling RYR1 RYR2 DAGLA CCKBR CNR1 PLCB1 TRPC1 CCK RYR3 GNAI1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260610%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCB SPHK1 SGMS2 SGPP1 MTOR UGCG PRKCA TERT S1PR1 RB1 DEGS1 S1PR2 CDK4 KDSR S1PR5 RPP38 SPTLC1 CDK2 PLCB1 CERS2 CDKN1A MAPK1 GLB1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260610%WP704%HOMO SAPIENS Methylation pathways PNMT NNMT TPMT MAT1A INMT MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260610%WP3298%HOMO SAPIENS Melatonin metabolism and effects CAMK2A CYP1A2 CRY2 CRY1 PRKCA CYP1A1 CYP1B1 GSK3B CYP2C19 FOXO1 NFKB1 ADRB1 TRAF6 PER2 CALM1 ACHE MAOA ASMT ECE1 hCG_2014051 SULT1A1 AANAT MAP2 APOE EDN1 CSNK1D IRAK1 SIRT1 PER1 MTNR1A PER3 MTNR1B GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260610%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260610%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 GLYCINE METABOLISM%WIKIPATHWAYS_20260610%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e BLADDER CANCER%WIKIPATHWAYS_20260610%WP2828%HOMO SAPIENS Bladder cancer HBEGF THBS1 RB1 TYMP RASSF1 CCND1 ERBB2 EGF MMP2 MYC DAPK2 RPS6KA5 UPK3A MAP2K1 MAP2K2 PIK3R2 PIK3R1 NRAS MAPK1 CXCL8 RAF1 EGFR ARAF CDKN2A FGFR3 CDK4 MDM2 CDKN1A SRC HRAS MMP9 VEGFA EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260610%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells IL6 EGF CD63 CD81 GATA4 HEL-S-44 IGF1 ETS2 BIRC5 TLR4 PTEN opn HEL-S-102 EGFR MMP9 STAT3 KDR STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260610%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL4 MYL1 MYL2 MYL3 MYOM1 HEL-S-273 TTN TNNI1 TNNI2 TNNI3 DMD HEL-S-108 MYBPC3 TMOD1 ACTN2 TPM3 TNNC1 TPM1 TNNC2 ACTN4 ACTA2 DES TNNT1 TNNT3 MYH8 TCAP MYH6 ACTG1 ACTA1 HEL113 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260610%WP391%HOMO SAPIENS Mitochondrial gene expression PPP3CA SP1 CREB1 ESRRA MYEF2 MTERF3 TFB2M NRF1 GABPB1 TFB1M POLRMT PPRC1 HCFC1 CAMK4 TFAM PPARGC1A MTERF1 PPARGC1B GABPA ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260610%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 NR1C1 MVD PTGS2 WNT1 VEGFA PTGS1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260610%WP4022%HOMO SAPIENS Pyrimidine metabolism DPYS ENPP3 HEL74 TK1 POLE ENTPD1 ENTPD3 CAD NME2 NME3 CTPS2 NME4 DCTD NME6 NME7 POLR1A DPYD POLR1C CMPK1 POLR1D CMPK2 DTYMK POLR1F UPRT UMPS POLR1H DCTPP1 PRIM2 PRIM1 TYMS POLD3 POLD4 POLR2A POLR2B POLR2C POLR2D POLD2 POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2J3 RRM1 DUT RRM2 PNPT1 POLR2J2 POLR3GL DHODH POLE4 POLA1 UCK2 POLA2 UCK1 POLR3A POLR3B POLR3C POLE2 POLR3D POLE3 POLR3E POLR3F POLR3G POLR3H POLR3K TYMP ENPP1 RRM2B CDA TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260610%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap CTH MTR GCLM CBS INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260610%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260610%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260610%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 PSENEN NFKB2 BACE1 APP MSTN PSEN2 PSEN1 SIRT1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260610%WP4217%HOMO SAPIENS Ebola virus infection in host ITGA1 ITGB1 ITGA4 ITGA2 TBK1 EP300 HAVCR2 PIK3CD IRF3 IRF7 SOCS3 TFAP2A REL IKBKE RIGI CLEC4M CLEC10A ICAM2 ICAM3 HLA-DOA HLA-DOB VPS39 KPNA1 VPS18 CD300A VPS33A ACTN1 HLA-B HLA-C TIMD4 RFC1 HLA-A HLA-F HLA-G HLA-E TIAM1 ADAM17 TYRO3 TSG101 SCIN CLTCL1 HLA-DQA2 HLA-DQA1 VPS16 HLA-DRB5 CAV3 CAV2 EIF2AK2 EIF2S1 BST2 IL4 CD209 CLEC6A RAB5A HLA-DRB1 CLTC CLTB CLTA ASGR1 ITGB3 CTSL C1QBP ITGAV HAVCR1 MBL2 HLA-DPA1 RHOB RAC1 VAV2 NPC1 NPC2 RASA2 ITGA6 PIK3CA MFGE8 HLA-DQB2 RAB7A HLA-DQB1 RELB CDC42 HLA-DMA HLA-DMB FLNA FLNB DAB2IP MERTK ARHA AXL PAK1 NEDD4 VPS41 HLA-DPB1 MAPK1 RAB9A FOLR1 MAPK3 IQGAP1 EGFR STAT1 RELA CREBBP IGF1R PIK3R3 PIK3R2 PIK3R1 TLR4 NFKB1 NFKB2 ACTN4 ACTG1 PS1TP5BP1 VPS4A FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260610%WP5061%HOMO SAPIENS Fatty acid transporters HEL-S-104 FABP9 DBI FABP1 FABP2 ACSL1 FABP5 ACSL6 FABP6 FACL4 CD36 ACSL5 SLC27A4 ACSL3 MAPK CASCADE%WIKIPATHWAYS_20260610%WP422%HOMO SAPIENS MAPK cascade MAP2K4 MAPK10 PLCB3 SOS1 MAP2K1 MAP2K2 NRAS MAPK1 MAPK3 RAF1 MAP3K12 ARAF RRAS MBP MAPK14 RASA3 LAMTOR3 JUN SIPA1 SOS2 MAP2K3 GRB2 MAP3K2 MAPK12 MAP2 HRAS MAP2K6 MAP3K1 FOCAL ADHESION%WIKIPATHWAYS_20260610%WP306%HOMO SAPIENS Focal adhesion MAPK10 ITGA1 MYL2 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 PIK3CD VAV1 FYN CRKL CCND1 MAP2K1 SHC2 SHC3 SHC1 HGF CCND3 CCND2 ACTN1 RAF1 PXN RAP1A PDGFA JUN CAV3 CAV2 BCL2 MAPK9 GRB2 PTEN ITGB3 ITGAV HRAS RAC1 VAV2 ITGA6 PIK3CA RAPGEF1 SOS1 CRK DOCK1 CDC42 HEL-S-28 FLNA FLNB ARHA MAPK8 PAK1 MAPK1 MAPK3 EGFR BAD AKT3 MYLK2 ITGA2B TNC HEL114 sm-M20 ARHGAP35 MYLK3 MYLK MYLK4 COMP PPP1CC IBSP TNR HEL-S-80p MYL11 MYL5 PDGFRA MYL7 COL4A2 COL4A1 COL4A4 FLT1 COL4A6 TLN2 SRC TLN1 BLK SHC4 IGF1R TXK VEGFA KDR MYL12A MYL12B PRKCB VTN PDGFD CHAD PDGFC PDPK1 PRKCA MYL10 PIP5K1C THBS1 VASP SRMS TNK2 ERBB2 EGF TNK1 PTK6 PARVA PARVB COL1A1 GSK3B COL1A2 PIK3R3 PARVG PIK3R2 IGF1 COL5A3 COL5A2 PIK3R1 ITGB4 RASGRF1 LAMC2 opn LAMC1 ARHGAP5 ITGB8 RAC3 ITGB6 VAV3 VWF EMP2 COL2A1 ITGA7 PPP1R12C BIRC2 BIRC3 LAMA5 ACTN4 ROCK1 LAMA1 ROCK2 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN PAK6 ACTG1 PAK4 LAMB3 PS1TP5BP1 LAMB2 STYK1 LAMB1 VEGFD XB c-fgr ZYX NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260610%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 P2RY4 ADORA2A ADORA2B P2RY2 P2RY1 LPAR4 LTB4R OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260610%WP322%HOMO SAPIENS Osteoblast signaling TNFRSF11B PTH PTH1R SLC17A2 PDGFRA ITGB3 ITGAV COL1A1 BGLAP FGF23 IBSP TNFSF11 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260610%WP4316%HOMO SAPIENS miRNA degrading enzymes XRN1 EXOSC4 PNPT1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation PPP2CA DCTN6 HEL-S-93 DISC1 DCTN5 HEL2 DDC DCTN1 DCTN4 DCTN3 DBH HEL-S-77 YWHAQ CDK5 TH DYNC1H1 HEL-S-1 YWHAG PAFAH1B1 NDEL1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL1B MERTK POLR1A POLR1C CHTM1 POLR1D IL1RN MAPK1 CSF2 CSF1 POLR1F ZC3H8 IL36A IL36B POLR1H PSD4 CXCL13 ARL14 CKAP2L STAT1 IL23A POLR1G ANAPC1 ARF6 FBLN7 TMEM87B SLC20A1 RGPD8 GATA3 TULP1 POLR2H TTL IL1RL2 BCL2L11 POLR2K NT5DC4 POLR2L POLR2F IL36RN IL37 IL36G IL2 IL1F10 SOCS3 SOCS1 IL6 PLCG2 GRB2 IL1R1 IL1A RAC1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260610%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SHMT1 MTR HEL-S-51e SLC46A1 MTHFS FTCD DHFR MTHFD1 MTHFD2 FOLR1 MTHFD2L SLC19A1 TYMS HEL-S-70p METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260610%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PDHA1 MDH2 HEL107 PGAM1 HEL-S-51e GOT2 HEL-S-133P PYCR2 HEL-S-68p SDHB RPIA GLUD1 PFKL PSAT1 SUCLG2 ACO2 ALDOB PAICS ACLY FASN HEL-S-162eP FH HEL-S-30 ENO1 GLS HK3 SLC16A3 PSPH TIGAR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260610%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NFU1 NARF LYRM4 ABCB7 FDX1 FDXR HSCB CIAO2B FXN ISCU NUBP1 NUBP2 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260610%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy CAMK2A BACE1 NEDD4 SNAP25 RAB1A AKAP5 DAG1 ZNF547 TRAPPC3 PRRT2 PRKCE RAB11A GIGYF1 TRAPPC6B SCN8A KCNQ2 KCNQ3 KCNQ5 FGF13 SCN2A SCN4B FGF12 CALM1 VAMP2 STX1A NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260610%WP4564%HOMO SAPIENS Neural crest cell migration during development PIK3CA PIK3R4 MMP2 PIK3R3 ARHA PAK1 TWIST1 STAT3 AKT3 TIAM1 JUN PIK3CD PAK6 PAK4 EPHB6 TRIO PIK3R5 EPHB2 ARF1 EPHB1 EPHB4 EPHB3 NGFR BDNF CDH11 F2RL2 MMP9 RAC1 FOS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260610%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH PDP2 HEL-S-32 ME1 ME2 RETT SYNDROME%WIKIPATHWAYS_20260610%WP4312%HOMO SAPIENS Rett syndrome HDAC5 GRIN2B KDM5B TRRAP STXBP1 FOXG1 HTT GPS2 CRK CHD4 HDAC8 SYNE2 RHOBTB2 CECR2 SYNGAP1 TAF1B TBL1X HIVEP2 SCN1A SRRM3 GABBR2 EIF2B2 CDKL5 KCNJ10 SMARCA1 MEF2C NCOR2 GNAO1 XAB2 NCOR1 SMC1A TBL1XR1 IMPDH2 TCF4 HAP1 SHANK3 SMARCA4 SCN8A SCN2A GABRA3 HDAC1 ACTL6B BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260610%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK10 PRKAB2 PRKAB1 PRKAA1 MAPK8 G6PC1 MAPK1 MAPK3 PCK2 PRKAG1 PRKAG2 PRKAG3 CRP ACACB ACACA HMGA1 MAPK14 ACLY G6PC2 G6PC3 SLC27A2 PRKAA2 MAPK9 MAPK12 MAPK13 MAPK11 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260610%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes IGF1 HCN4 KCNE1 GJA1 TMSB4X ERG HAND2 KCNJ2 HCN2 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260610%WP3286%HOMO SAPIENS Copper homeostasis ADAM9 MT1B XAF1 PIK3CA STEAP1 STEAP2 MT1E BACE1 APP CCND1 GSK3B HEL-S-44 FOXO1 FOXO3A APC ADAM17 JUN SP1 STEAP3 STEAP4 MDM2 COX17 ATP7B COX11 ATP7A SLC31A2 SLC31A1 PTEN SLC11A2 ADAM10 COMMD1 MT4 MT3 CASP3 ATOX1 CCS MT1A SCO1 MTF1 MT1F PRNP MT1G ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260610%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 AGXT PC GOT2 GAD2 ASL GPT ABAT ASPA ASS1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260610%WP334%HOMO SAPIENS GPCRs class B secretin like CALCRL PTH1R GLP1R ADCYAP1R1 VIPR2 GIPR GCGR SCTR GPR64 CRHR2 GHRHR CALCR ADGRE5 ADGRL1 ADGRL4 ADGRL2 ADGRL3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260610%WP453%HOMO SAPIENS Inflammatory response pathway VTN THBS1 COL1A1 COL1A2 LAMC2 LAMC1 CD40 CD80 IL5RA IL2RG TNFRSF1B COL3A1 IL5 CD40LG LAMA5 IL2RA IL2RB THBS3 IL2 IL4 LAMB2 LAMB1 ZAP70 LCK IFNG TNFRSF1A NEUROINFLAMMATION%WIKIPATHWAYS_20260610%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 MTOR JUN CHUK NOS2 ASCC1 COX2 COX1 RELA NFKBIA MAPK8 TLR4 FOS EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260610%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 AOX1 COX1 HBB XDH HBA2 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL6 CXCL12 VEGFB IL1B VEGFC CSF2 CXCL8 CXCL1 IL23A TNF CXCL5 IL5 IL10 IL25 IL12B IL12A LGALS9 CCL20 IL2 IL4 TGFB1 IL13 IL17F IL17D REG4 VEGFD IL17C CCL28 IL17B IL17A CCL5 CCL2 MMP9 IFNG VEGFA CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260610%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 TAR SYNDROME%WIKIPATHWAYS_20260610%WP5362%HOMO SAPIENS TAR syndrome SUMO2 MAGOH NUDT17 HEL-S-76p DDIT4 RBCK1 CFTR SLC22A4 PEX11B FURIN TXN CLCN3 BCL2L13 ITGB1 TNFRSF14 ZFHX3 PEX19 NHERF1 UBE2I PYM1 PDZK1IP1 MITD1 CXCR4 LAMTOR1 FLT3 EGFR STAT3 FARP2 POLR3GL LCK HDAC2 POLR3C SIRT1 POLR3F POLR3G CD160 SLC34A3 NFKB1 HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E HAMP ANKRD35 EIF4A3 CD3D GPR89B IFNG CCAR2 AKAP10 SLK MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260610%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement PLCG1 JUN PRKCQ HEL114 MYL2 CREB1 MYLK MAPK1 LPP ACTN1 ITGB3 MFAP5 MAPK3 TJP1 ITGAV PXN GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260610%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis IL6ST CD244 IL2RA PHF19 SLC22A4 HLA-DRB1 STAT4 FCRL3 ITGAV CD40 PTPN22 BLK TRAF1 MHC2TA CTLA4 PADI4 CCR6 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260610%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition MTOR TBC1D4 INSR SLC2A4 IRS1 RPS6 RPS6KB1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260610%WP430%HOMO SAPIENS Statin inhibition of cholesterol production ABCG8 ABCG5 LPL SCARB1 MTTP HMGCR LIPC APOB ACSS1 LDLR CYP7A1 PLTP ABCA1 FDFT1 DGAT1 APOA2 APOC3 PDIA2 APOA4 APOA5 SQLE SOAT1 APOC2 APOC1 APOE IL9 SIGNALING%WIKIPATHWAYS_20260610%WP22%HOMO SAPIENS IL9 signaling MAP2K1 MAP2K2 GRB2 PIK3R2 STAT5B PIK3R1 MAPK1 CDK9 IL9 JAK3 MAPK3 IL9R STAT1 JAK1 STAT3 IL2RG HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260610%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex EP300 SMARCA4 BCL2 ATM GABPB1 PTEN CREBBP FOXO3A SMAD4 GABPA FLT3 TERF2 ZFX ETV6 DNMT3B BCL2L1 MCL1 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260610%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway RDX RAB35 KIF23 OCRL EZR HEL70 MYL2 SEPTIN2 ARHA MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260610%WP129%HOMO SAPIENS Matrix metalloproteinases TCF20 MMP21 MMP20 MMP25 MMP2 MMP24 MMP27 MMP26 MMP28 TIMP4 MMP7 MMP3 MMP10 MMP12 MMP11 MMP14 MMP16 MMP15 MMP23B MMP17 MMP19 TNF hEMMPRIN MMP9 TIMP3 TIMP1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260610%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN ACE2 NRP1 VEGFA KDR 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5400%HOMO SAPIENS 6q16 copy number variation GHRL AgRP SIM1 POMC INS INSR LEP BDNF NTRK2 GHSR MC4R NPY LEPR PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260610%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases H3F3B SNAP23 AKT1S1 KHK HEL-S-68p MYL2 HEL-S-30 STAT3 H2AX MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260610%WP2005%HOMO SAPIENS miR targeted genes in muscle cell HES1 ITGA2 TYMS POLR2C POLD2 EHMT1 POLE4 POLA2 EZH2 MCL1 BACE1 CXCL12 LPL VPS39 NRP1 SNAP23 CPNE8 VEZT SPARC MTRR TMEM41B CLDN1 BACH1 PWP1 CHORDC1 RAVER2 MAPK7 CIAO2A SEC62 CDK5RAP3 MBNL1 ATP6V0E1 HEL-S-303 CACNA2D1 IFRD1 MAPK12 FNDC3B FNDC3A C1QBP PISD CARHSP1 WDR82 FAR1 TMEM87A HACD3 UBE2J1 MRPL20 COMMD9 RDH10 GRPEL2 HMOX1 ATP6V1C1 SNX6 GSTM4 RAB27B MOV10 NCEH1 PDE3A SFXN1 STRN ANP32B RNP24 ARF4 AXL TRAM1 NEDD4 GFM1 ASH2L MAGT1 PTPRF MRC2 PANX1 COIL SERP1 TMEM43 EGFR HYAL3 TMED3 DHX15 PPP1R7 GNPNAT1 NELFCD SH3BP4 TMED7 CTSC MRPS24 LAMTOR3 ELMOD2 TMT1A AP3B1 SLC7A6 CDCP1 VSNL1 CSDE1 FRG1 PXDN PTMA AMIGO2 FSTL1 NAPG PTPA NT5E PGRMC1 USP1 SHOC2 SRSF10 MPZL1 CA12 SPRYD4 AP3D1 TTC9C ARHG ARCN1 WDR11 SPCS3 DOCK5 TPPP3 GPAM NFIA SNX15 CCNG1 PKN2 LAMTOR5 TUSC2 LTN1 PPP3CA CPOX ARID4B TXN2 FADS2 ABHD10 COL1A1 POGLUT3 COL1A2 KPNA3 MYLIP SLC38A1 RARS1 ATG9A ITGB4 SNAP29 STX7 UBE4A LAMC2 CDKAL1 LAMC1 HEL-S-66 RAB30 SYPL1 GPD2 NCL PPIF GEMIN7 PPIB PHLDB2 ABCG2 SRSF9 RAI14 NOTCH2 TMED10 CBFB SLC1A4 ADIPOR2 RTN4 CORO1C CAMTA1 SLC38A5 CD164 BRPF3 GFPT1 SLC4A10 TBCA IGF2R GNL3L P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM SLC25A1 CALCOCO2 DOCK7 TNFAIP2 ATP2A2 SSNA1 ADAR CYR61 SYNE1 TMEM109 ACP2 SCYL1 HSDL1 HEL-S-47e NOTCH1 TGFBR2 RCN2 RFT1 RBMS1 DSG2 SLC25A13 SEC23A LUZP1 NUFIP2 NXN YWHAQ UHRF1 HSD17B12 ACVR1B GNA13 DNAJB1 CAND1 TDG CSF1 TP53INP1 IGF2BP1 E2F3 ZNF622 CDIPT PDLIM7 SLC25A24 SLC12A2 GALNT7 ANAPC1 NHERF2 GALNT1 CYP51A1 SLC4A7 RQCD1 MYO1E FMNL2 SLC25A32 CUL4B BET1 IRS1 MTHFD2 GRIA2 HEL-S-30 EIF4E SDCBP RB1 CCND1 SLC7A11 PSAT1 ERG PLK1 RHEB TNFRSF10B BCL2 CDK6 CDKN1A CDKN1B ARID1A SYNE2 SPTLC1 HMGA1 MAPK14 KIT GJA1 CSNK1D FGF2 PRKCI THBS1 CYP1B1 ERBB3 ERBB2 CEBPB HEL-S-273 HEL-S-108 COL3A1 TPM3 TPM1 LMNB2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260610%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES1 NOTCH1 MESP2 HES7 LFNG EPHA4 FGF8 RIPPLY2 WNT3A TBX6 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260610%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy DDR2 FGFR2 PIK3CA PRKCA RELB COL1A1 FGFR1 CEBPB MAPK1 opn NFKB1 LAMTOR1 MAPK3 STAT3 COL2A1 FGF23 AKT3 COL3A1 FGFR3 JUN RELA CTGF IBSP ACAN COL10A1 VHL SOX9 JUNB CNMD P4HTM NTRK1 JUND NGF RUNX2 HIF1A GANC FOSL2 VEGFA FOSL1 KDR FOSB FOS FGFR4 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260610%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CAMK2A MAPK10 CREB1 RPS6KA5 PRKAA1 RANBP9 IGF2BP1 APC ACACB CRTC1 IRS1 CDH2 TRAF6 GRIA2 NTRK1 NGF FYN EIF4E GRIA3 MAP3K1 RPS6KB1 GRIN2B CYFIP1 NCF1 NCF2 SIRPA RPS6KA1 CSNK2A1 GABRB3 FRS2 FRS3 DOK5 SQSTM1 HEL-S-15 KCNN2 MAP2K1 EIF2S2 EEF2 MAP2K2 SHC2 NFATC4 SHC3 DOCK3 SHC1 YBX1 NCK2 TSC2 NCK1 KSR1 SYN1 KCNA3 NTF3 MEF2C SH2B2 SH2B1 RPS6 RAF1 LINGO1 SORT1 NTRK2 KIDINS220 NTRK3 MARCKS CAMK1 TIAM1 RAP1A CDK5R1 ADAM17 EIF4EBP1 PPP2CA JUN PRKAA2 EIF2S1 MAPK9 NFKBIA GRB2 MAPK7 CDK5 MAP3K2 GRIN1 NGFR BDNF CASP3 HRAS RAC1 VAV2 NCAM1 CDC42 MAPK8 CDKL5 MAPK1 PTPRF PTK2B MAPK3 BAD CNR1 STAT1 STAT3 IKBKB PTPN11 MAPK14 IKBKG MTOR CHUK RELA STAT5B SRC ARHG SHC4 PLCG1 PDPK1 MAP2K5 GSK3B PIK3R2 PIK3R1 RASGRF1 NFKB1 FOXO3A VAV3 GRIP1 CAMK4 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260610%WP5603%HOMO SAPIENS Caffeine in myocytes MYL1 MYL2 MYL6 MYL3 HEL-S-273 RYR1 TNNI1 RYR2 TNNI2 TNNI3 HEL-S-108 RYR3 TPM3 ACTG2 TNNC1 MYH13 TPM1 TNNC2 MYH1 MYH2 ACTA2 MYH4 MYH7 TNNT1 TNNT3 MYH8 MYH6 ACTG1 PS1TP5BP1 MYL11 ACTA1 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260610%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LPL SCARB1 LIPC VLDLR APOE LDLR PLTP APOA2 APOA4 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260610%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SUV39H1 SIX1 SUZ12 FOXC2 PRRX1 KDM1A KLF8 ZEB2 ELF3 ELF5 TGFB1 SNAI1 SNAI2 GSC2 HDAC2 TWIST1 SIRT1 HDAC1 TCF4 EZH2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260610%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta TNFRSF11B P3H1 BMP1 P4HA1 SP7 MBTPS2 COL1A1 COL1A2 PPIB LRP5 P4HA2 PLOD2 MIA3 TNFRSF11A PLOD1 LRP6 ADAMTS2 TMEM38B COLGALT1 IFITM5 FZD1 WNT1 MBTPS1 CRTAP TNFSF11 P3H2 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260610%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals PIK3CA PRKCA HMOX1 NQO1 GCLM KEAP1 AIMP2 GCLC MAF SLC7A11 MAPK8 NFE2L2 CEBPB EPHB2 KALLMANN SYNDROME%WIKIPATHWAYS_20260610%WP5074%HOMO SAPIENS Kallmann syndrome PTPN11 ANOS1 PIK3CA FRS2 PLXND1 MYRF FGF8 LHB SEMA3E FGFR1 MAP2K2 OLIG2 GRB2 SOX10 TMEM98 PROK2 GNRH1 OTX2 MAPK1 NEUROG1 ASCL1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP496%HOMO SAPIENS Steroid biosynthesis F13B HSD17B1 HSD17B2 HSD3B2 HSD17B3 HSD17B4 HSD17B7 HSD3B1 CYP17A1 CPN1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260610%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC7A5 SLCO1C1 SLCO3A1 SLCO4A1 SLC16A2 SLCO1A2 SLC16A10 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260610%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT3 GPAM AGPAT4 LIPF GNPAT LIPE GPD1 LIPC PLPP3 PLPP2 PLPP1 PNPLA2 DGAT1 LPL AGPAT5 DGAT2 MOGAT3 MOGAT2 MOGAT1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260610%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis MAPK14 BAX BCL2L11 BCL2 BBC3 MAPK12 MAPK13 CASP9 MAPK11 CASP8 APAF1 CASP3 BAD TNFSF6 TNF FADD BCL2L1 MCL1 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260610%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets IRF4 BATF3 FLT3LG IKZF1 TPO GIG8 IRF8 CSF2 CSF1 SPI1 RUNX2 STAT3 TCF4 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260610%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A GRIN2B DLG4 CDC42 SYNGAP1 ITGB1 PAK1 ADGRL1 RAP1A SHANK3 SPAAR PS1TP5BP1 CTNND2 ARHGAP44 SHARPIN DLGAP1 MAP3K7 SPTAN1 LZTS3 BAIAP2 GRIN1 GRIA2 ARHGEF7 HCN1 HRAS HOMER1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260610%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD PON1 HEL126 LIPA CES2 CES1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260610%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 PTPN11 NFATC3 NFATC2 JUN NFATC1 CD3G BATF PDCD1LG2 CD3E CD8B CD8A NFATC4 ZAP70 HLA-DRB1 LCK PDCD1 NFKB1 HLA-A CD3D IFNG STAT3 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260610%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways HEL-S-87p HSPD1 HES5 KCNJ8 NFYA HEL-S-93 EGR1 GCK NR3C1 PRKAR1B REST HEL2 SST PRKAR1A DDC GPD1L CREB1 YWHAQ TH HEL-S-1 HES1 YWHAG IL1RN CXCL8 TNF EP300 GATA3 IL6R IL10 HEL-S-162eP SLC1A3 NGF IL6 YBX1 G6PC1 MEF2C NTRK2 SNAP25 JUN CAV3 SP1 NR1A2 SCN4B VAMP2 GRIN1 CTCF BDNF CASP3 HEL-S-125m POU2F2 MYB IL1B PPARGC1A ASCL1 RYR2 GJA1 MAOA ECE1 CREBBP MAP2 HIF1A VEGFA HTR1A HTR2A CHRM2 AQP4 RORA SOX2 ADCYAP1R1 VIPR2 C4A PKNOX1 CHRNB2 CHRNB4 CPT1A TSPYL1 POU3F2 CEBPB RUNX3 SLC9A3 NFKB1 NR3A2 NFKB2 LMX1B TPH2 DLX2 TPH1 CHRNA7 CREM BHLHB2 GATA2 C4B_2 NEUROD1 DEAF1 RET ChAT SCN3B SPTBN1 NKX2-2 PBX1 PHOX2B PHOX2A TF TLX3 FEV PAH SP3 GNB3 TCF3 IL13 CC2D1A TP73 FOXM1 FREP1 SCN5A ACADM SNTA1 NKX3-1 PPARGC1B EN1 TACR1 SSTR2 IL1A POU5F1 HADHB HDAC1 NOS1AP AVP SLC25A4 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260610%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways MAPK10 REST CYP46A1 KIF5A CREB1 RPS6KA5 ABCG4 ABCG1 PI3 DHCR7 AHI-1 OPA1 PRKAA1 SIN3A HMGCS1 C1QA BNIP3 NR1H2 RAB3GAP1 SLC12A2 CYP51A1 HMGCR BCL2L11 PIK3CD GABRG3 GABRG1 HDAC2 EIF4E BCL2L1 RPS6KB1 PIK3R4 GABRB3 IL6 GABRB2 GABRB1 PRKAB2 MAP2K1 PRKAB1 MAP2K2 TSC2 TSC1 MAP3K10 RAF1 NTRK2 PRKAG1 PRKAG2 PRKAG3 EIF4EBP1 SREBF2 RHEB GABRE SP1 PRKAA2 GABRQ ABCA1 GABRA2 GABRP BCL2 MAPK9 SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 PIK3R5 PTEN RPTOR CASP8 BDNF CASP3 HRAS PIK3CA HTT DEPTOR IL1B MAPK8 AKT1S1 MAPK1 PPARGC1A RICTOR MAPK3 EGFR BAD IKBKB HAP1 AKT3 MBP MTOR BAX APOE HEL-S-29 PIK3C2G PIK3C2B MAP2K4 EGF PIK3R3 PIK3R2 PIK3R1 NFKB1 MLST8 NEUROD1 HDAC1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260610%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PRKCB IL6ST MAPK14 JUN PRKCE PPP3CA MAP2K3 MYEF2 GATA4 NFATC4 ARHA CALM1 MAPK8 MAPK1 CAMK2D CTF1 MAPK11 EDN1 STAT3 RAC1 FOS FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260610%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CYP2E1 CEBPB MTR HEL-S-53e CREB1 ADH5 CBS G PROTEIN SIGNALING%WIKIPATHWAYS_20260610%WP35%HOMO SAPIENS G protein signaling PLCB3 PRKAR1B PRKAR1A GNAS ARHA GNA13 GNAO1 HEL159 GNGT1 AKAP12 AKAP11 GNGT2 GNAI1 RRAS PPP3CC PRKACG PDE4B PDE4A PDE8A PDE4D PRKD3 AKAP9 ADCY3 ARHGEF1 PRKD1 GNAZ ADCY1 PDE1C PDE1B ADCY8 PDE1A AKAP8 GNAI3 ADCY6 AKAP7 AKAP6 ADCY5 AKAP4 ADCY9 GNA14 GNA15 GNG3 GNG10 GNG5 GNG4 GNG7 GNG8 KCNJ3 GNG12 GNG11 GNG13 GNAL PRKCB GNB2 PRKCI GNB1 PRKCH PDE7B GNB5 PRKCA PDE7A PRKCQ PRKCZ PPP3CA NRAS AKAP5 PRKCE GNA11 GNB3 CALM1 HRAS AKAP10 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260610%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 IKBKG CHUK NFATC1 NR1i1 NR3C1 PPP3R1 IL6 MED14 PPP3CA MAP2K3 RELA NFKBIA RXRA NFKB1 SMAD4 MAP2K6 MAP3K1 TNF IKBKB CHOLESTASIS%WIKIPATHWAYS_20260610%WP5238%HOMO SAPIENS Cholestasis SCARB1 EPHX1 HMGCR ABCC3 ATP8B1 ABCB4 LDLR ABCG8 ABCC2 NR1I3 SLC22A1 ABCG5 NR1H4 ABCB11 RXRA SLCO1A2 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260610%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma MTOR SOS1 RHEB SOS2 EGF TGFA TYK2 GRB2 EREG BTC TSC2 TSC1 PTEN NRAS RPTOR JAK3 RAF1 HRAS JAK1 STAT3 AKT3 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260610%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CAMK2A NRXN3 MAPK14 PRKCA RPS6KA1 CREB1 RPS6KA5 BCL2 CALM1 SYT2 NRXN1 NRXN2 CAMKK1 CCND2 MAPK1 CAMKK2 CAMK4 HNRNPL PPARGC1A DRD1 PRL BDNF NGF NCAM1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260610%WP4172%HOMO SAPIENS PI3K Akt signaling DDIT4 CREB1 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 GNGT1 GNGT2 IL6R IFNAR2 IFNAR1 GNG3 GNG10 JAK3 GNG5 GNG4 GNG7 GNG8 GNG12 GNG11 GNG13 BCL2L1 MCL1 IFNB1 GNB2 GNB1 GNB5 IL6 TGFA PCK1 G6PC1 ATF2 PPP2R2A RPS6 TCL1B TCL1A NTRK2 PPP2R1B CREB3L3 PPP2R1A CREB3L4 CREB3L2 KPG_010 CDC37 ATF4 PDGFA EPHA2 LPAR2 LPAR3 CD19 IGF2 COL9A1 PRKAA2 COL9A3 COL9A2 INS IFNA5 IFNA4 IFNA7 IL4 IFNA6 IFNA1 IFNA2 IFNA8 GYS2 SYK OSMR SGK1 SGK2 ITGB3 PRL PHLPP2 PHLPP1 ITGAV GYS1 PKN3 NTF4 OSM CSHL1 RAC1 GHB2 KITLG GHB3 PKN1 CSF3 ITGA6 CSF3R CHRM1 EPO FGF3 FGF4 FGF6 FGF7 FGF9 IFNA13 IFNA14 IFNA16 IFNA17 PRLR COL4A3 COL4A5 IFNA10 CSH2 EFNA5 EFNA4 FGF20 FGF22 FGF21 IFNA21 EGFR FGF17 EFNA1 GH1 EFNA3 FGF14 EFNA2 IL7 FGF19 FGF18 GNB4 IL7R ITGA2B FGF10 TNC HSP90AB1 FLT4 GHR PPP2R5E PPP2R5B PPP2R5A PPP2R5D COMP PPP2R5C RBL2 IBSP CREB3 TNR COL6A1 IL3RA COL6A6 COL6A5 CREB5 COL4A2 ATF6B COL4A1 GNG2 COL4A4 PPP2R3C COL4A6 ANGPT4 ANGPT2 LAMB4 PPP2R3B PPP2R3A EPOR PPP2R2C PPP2R2B VTN PPP2R2D PDGFD PIK3AP1 CHAD PDGFC PKN2 COL1A1 GSK3B COL1A2 PIK3R3 PIK3R2 PIK3R1 ITGB4 NRAS LAMC2 LAMC1 MLST8 ITGB8 FOXO3A ITGB6 VWF COL2A1 ITGA7 LAMA5 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN LAMB3 LAMB2 LAMB1 VEGFD XB LPAR4 ITGA1 LPAR1 STK11 PRKAA1 CSF1 BCL2L11 IRS1 PIK3CD FGF8 IL2 NTRK1 NGF EIF4E EIF4B FGFR4 RPS6KB1 CCND1 MYC MAP2K1 MAP2K2 HGF TSC2 CCND3 TSC1 CCND2 NTF3 EIF4E1B RAF1 CCNE2 CCNE1 EIF4EBP1 PPP2CA RHEB CDK4 CDK2 FGF13 BCL2 CDK6 MDM2 GRB2 FGF12 CDKN1A PIK3R5 CDKN1B PTEN BRCA1 F2R RPTOR CASP9 NGFR BDNF HEL-S-125m HRAS JAK1 PIK3CA SOS1 MYB MAPK1 MAPK3 FLT3 BAD IKBKB AKT3 IKBKG G6PC2 MTOR G6PC3 CHUK KIT SOS2 CSF1R FLT3LG RELA PDGFRA IL3 FLT1 RPS6KB2 ANGPT1 FGF2 VEGFA IGF1R KDR FGFR2 PDPK1 PRKCA THBS1 EGF CHRM2 FGFR1 IGF1 TLR4 opn INSR NFKB1 PCK2 IL2RG FGF23 FGFR3 IL2RA IL2RB GNB3 TNFSF6 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260610%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A12 SLC25A22 GOT2 SLC25A13 GLUD1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260610%WP2596%HOMO SAPIENS Gastric acid production CBLIF SCT GAST PGA3 VIP PGC PGA5 MUC6 CCK MEVALONATE PATHWAY%WIKIPATHWAYS_20260610%WP3963%HOMO SAPIENS Mevalonate pathway HMGCS1 HMGCR MVD FDPS MVK PMVK ACAT2 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260610%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260610%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 BIRC3 BAX TRAF2 CYCS RIPK3 TRADD CASP9 CASP8 CASP3 RIPK1 TNF FADD TNFRSF1A HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260610%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ tal-1 HBG2 LDB1 HBG1 LMO2 HBB HBE1 HBA2 HBD GATA1 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260610%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GRIN2B GRIN3B GRIN3A PIK3CA DLG4 ARC PRKAB2 SYNGAP1 NF1 GSK3B PRKAB1 PIK3R3 PRKAA1 PIK3R2 PIK3R1 TSC2 TSC1 NRAS MAPK1 MAPK3 NTRK2 UBE3A PRKAG1 CACNA1C PRKAG2 PRKAG3 AKT3 SHANK3 EIF4EBP1 MTOR RHEB PRKAA2 PIK3CD PTEN GRIN1 CAMK4 RPTOR BDNF HRAS HOMER1 RPS6KB1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260610%WP5355%HOMO SAPIENS Metabolic epileptic disorders HEL-S-87p SPCS1 CDO1 PFKM PFKP HEL60 GCK OTC CBS SFXN1 ECHS1 PC HEL-S-162eP HEL-S-30 HEL-S-20 ENO1 HK3 PSPH PDHA1 MDH2 PGAM1 SHMT1 CTH HEL-S-51e GOT2 HEL-S-133P HEL-S-68p ASL GPT ASS1 GLUD1 PFKL PSAT1 ALDOB ETHE1 SUOX PCK1 G6PC1 SLC2A4 MOCS2 MOCS3 GLS2 GLDC SLC2A2 SLC2A3 ENO2 ENO3 GPHN HK2 DHTKD1 MPC1 FBP1 XDH MPC2 PHGDH DLAT AASS ARG1 PGAM2 AMT SLC25A15 BTD SLC25A5 ALDH7A1 DLD MOCS1 FBP2 GCDH SLC25A1 SLC7A2 ACAT1 HLCS PKLR AADAT HEL-S-32 SQOR HEL-S-281 HEL-S-49 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260610%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling PIK3CA SOS1 SALL4 AXIN2 TTI1 GAREM2 PYGO1 RETN DEPTOR CSNK1A1 BCL9 NFKBIE AKT1S1 MAPK1 MAPK3 FLT3 EGFR APC NR1C2 STAT3 IKBKB AKT3 IKBKG MTOR CHUK IL6R KIT FLT4 SOS2 CSF1R PIK3CD LEF1 RELA RUNX1T1 PDGFRA JUP ZBTB16 FLT1 NTRK1 SRC IGF1R KDR FGFR4 REL FGFR2 IL6 CCND1 MYC MAP2K1 GSK3B ULK2 FGFR1 MAP2K2 SHC1 TSC2 KSR1 TSC1 FOXO1 INSR NFKB1 MLST8 RAF1 NTRK2 FGFR3 JUN EPHA2 RHEB PML MDM2 NFKBIA GRB2 TCF3 CDKN1A LRP5 PTEN RPTOR LRP6 NGFR HRAS WNT1 FOS RARA BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260610%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation NOG SMAD6 BMPR2 TOB2 TOB1 BMPR1A SMAD1 SMAD4 RUNX2 BMP2 SMURF1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling PIK3CA RAPGEF1 ITGA1 SOS1 CRK CRKL DOCK1 MAP2K1 ITGB1 MAP2K2 MAPK8 PAK1 HGF MAPK1 PTK2B MAPK3 RAF1 PXN STAT3 RAP1A PTPN11 JUN GRB2 PTEN SRC HRAS PTGS2 MAP4K1 FOS MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260610%WP2001%HOMO SAPIENS miR targeted genes in adipocytes SRSF9 CAP1 TMED10 TGFBR2 CYP1B1 IGF2R LPL CEBPB PHC2 ELOVL5 SRSF10 FADS1 PICALM TMEM43 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260610%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 ARID1A ARID1B RB1 SMARCD1 SMARCD2 SMARCD3 SMARCC1 SMARCC2 GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 CDKN2A PTCH1 SMARCA4 GLI3 SUZ12 CDK4 CDK6 H3F3B EED ACTL6B ACTL6A SMO EZH2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260610%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX15 ALOX12 PLA2G5 ALOX15B PRXL2B PTGES PLA2G6 ALOX5 ALOX5AP LTC4S PTGS2 PTGIS PTGS1 PLA2G4B SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260610%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD IKBKG CHUK NFKB1 THBD HMGB1 AGER RELA IKBKB NFKBIA CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260610%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL5 IL10 VIP CD80 IFNG IL12A CTLA4 IL4 IL2 TGFB1 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260610%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADVL SLC22A5 ACSF2 CPT2 ACADL EHHADH SLC25A20 ACADS CPT1A ACADM PECR ACSL1 HADHB FACL4 ACSL3 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma PIK3CA TGFBR2 DDIT4 NOTCH1 KEAP1 STK11 PRKAA1 RICTOR EGFR CDKN2A AKT3 MTOR TERT TRAF3 RELA MAML1 SESN2 TP63 NUMB IRF6 AJUBA CSMD3 RPS6KB2 FKBP1A SMAD4 FAT1 EIF4E LTBR IGF1R FADD VEGFA REL PDPK1 RB1 CCND1 ERBB2 FGFR1 MAPKAP1 PIK3R2 TSC2 PIK3R1 NFE2L2 TSC1 NRAS SESN1 NFKB1 NFKB2 MLST8 RPS6 BIRC2 EIF4EBP1 FGFR3 NOTCH2 RHEB CDK4 PRKAA2 CDK6 CDKN1A PIK3R5 PTEN RPTOR CASP8 HRAS HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260610%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GJB6 FGFR2 CCND1 MYC ITGB1 CCND2 NFKB1 PTCH1 LAMA5 PDGFA SHH LEF1 SNAI1 LRP5 TP63 PDGFRA BMP4 RUNX2 FOXI3 FZD1 TNLG7C INHBA NCAM1 GTPBP4 SMO EDAR ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 EPHX2 ALOX5 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260610%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer POLE SIN3A WEE1 E2F3 RBBP4 PRIM1 TYMS POLD3 SUV39H1 CCNA2 HMGB1 RRM1 RRM2 DHFR POLA1 POLE2 MCM7 TOP2A ORC1L HMGB2 SMC2 RB1 SKP2 RFC3 CCND1 RFC4 PRMT2 MYC SAP30 CHEK1 TFDP1 TFDP2 RBP1 PCNA TTK NPAT CDC45 HLTF CCND3 E2F2 CDC25B RBBP7 MSH6 H2AZ1 PLK4 CDT1 RPA1 RAF1 FANCG RPA3 SMC1A CCDC6 PRKDC ZNF655 CCNE2 CCNE1 BARD1 CCNB2 CCNB1 CDC2 MCM3 CDK4 FAF1 CDK2 MCM6 CDK6 MDM2 CDKN1A CDKN1B MAPK13 SMC3 HDAC1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260610%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome HEL-S-87p HEL-S-100n C16orf54 CCT6A TAOK2 YPEL3 NR3C1 MAPK3 CDIPT KMT2C TRAF2 MAP2K3 PPP2R5D TRAF6 TBX6 MLL2 MAP2K6 REL EZR HEL70 PCNA NFKB1 PPARG CCDC6 SMEK1 DOC2A PPP2R1A FAM57B FIMP CCT6B PPP2CA PAGR1 PRRT2 SPN PPP4R1 PPP4R2 PPP4R4 UNC13B UNC13A PARP4 HEL-S-69 PPP4R3B ASPHD1 TCP1 KCTD13 ZG16 INO80E PAXIP1 HDAC3 MVP PTEN GDPD3 CORO1A HIRA HIRIP3 CASP8 PPP4C CCT8 CCT7 BPTF CCT4 IGBP1 HEL-S-90n SIAH1 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5408%HOMO SAPIENS 15q25 copy number variation SPCS1 SH3GL3 HTT RAMAC ZNF592 RNMT EGF BNC1 AGAP2 TENT4B BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB HOMER2 NMBR RYR1 WDR73 RYR2 AP3B2 DNM3 RAF1 SPCS2 SYNJ1 ALPK3 ZSCAN2 SHANK1 SHANK3 PDE8A AP3D1 SPCS3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260610%WP5606%HOMO SAPIENS Beta globin gene expression regulation NR2C2 GATAD2B KLF1 MTA2 ZFPM1 ZBTB7A MYB HBB KDM1A HDAC2 tal-1 HBG2 LDB1 PPARGC1A HBG1 LMO2 HBE1 HBD GATA1 HDAC1 CHD3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260610%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 BCL2 MCL1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260610%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens HSPD1 MTOR ATF4 GDF15 MARS1 OMA1 IRS1 PHB2 SLC7A7 MYC CLPP LONP1 LONP2 EIF2A TSC2 SESN2 TSC1 FOXO1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5153%HOMO SAPIENS N glycan biosynthesis RFT1 DPAGT1 B4GALT2 B4GALT1 TUSC3 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG6 ALG5 ALG2 ALG14 ALG13 ALG3 ALG12 ALG1 ALG11 ALG10 DDOST DPM1 DPM2 DPM3 GCS1 MAN1B1 ALG10B RPN2 RPN1 FUT8 GANAB MAN2A2 MAN2A1 MGAT5 MGAT5B MGAT3 MGAT1 MGAT2 MPDU1 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B STT3A STT3B 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5380%HOMO SAPIENS 5q35 copy number variation MAGED1 MAPK10 ABRAXAS1 USH1C ABHD5 BRCC3 NTN1 SOS1 COX5A COX7A1 INPP5D LMAN2 RAB24 COX3 ZNF346 SNCB DRD2 SNCA PRELID1 RNP24 MAPK8 PTPRN2 NOP16 MUPCDH HIGD2A TSPAN17 CXCR4 ANKS4B MXD3 PDLIM7 GNAI1 FGF19 PNPLA2 GNAI3 H3F3B EED ADAM10 SRC HK3 IGF1R FGFR4 PLCG1 GRIN2B FRS2 MYC H2AX PTH SLC34A1 PIK3R1 HEL-S-273 EIF4E1B PRR7 COX7B BARD1 KIAA1191 FAF2 TMED10 JUN DDX41 TRIAP1 COX6A1 COX2 COX7C COX1 BABAM1 BABAM2 UIMC1 CYP7A1 CAPN3 NELFB KDM6B MAPK9 ARL10 GRB2 COX8A TMED9 RNF44 UNC5A FBXW7 CLTB MYO7B BRCA1 COX6B1 GRIN1 ARFGAP2 HIC2 DOK3 GPRIN1 CDHR2 FAM193B PFN3 DBN1 RGS14 MAX CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260610%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CAMK2A CREB1 GNAS ARHA MAPK8 MAPK1 CXCL8 CRHBP SULT2A1 MAPK3 TRIM28 GNAO1 DKFZp686L0365 HSD3B2 KRT1 ERN1 CYP21A2 IVL TCF4 CACNA1H HSD3B1 GNAI1 CYP11A1 STAR ACACA MAPK14 KRT14 GJA1 GNAZ RELA IL2 ECE1 JUNB JUP JUND FOSL2 FOSL1 FOSB TFAP2A PRKCB PLCG1 GNB2 PRKCI GNB1 GNB5 PRKCA PRKCQ POMC MAP3K5 PLCG2 CRH MAP2K1 GSK3B CRHR2 TLR4 NFKB1 RAF1 GNA11 PRKAA2 SP1 BCL2 MAPK9 NFKBIA GNB3 TGFB1 CASP9 IL18 CASP3 CASP12 FOS GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260610%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis HEL-S-87p PDHA1 MDH2 PFKM PGAM1 PFKP GOT2 HEL-S-133P GCK HEL-S-68p PFKL ALDOB PCK1 G6PC1 SLC2A4 SLC2A2 SLC2A3 ENO2 PC ENO3 HK2 MPC1 FBP1 MPC2 DLAT HEL-S-162eP PGAM2 DLD FBP2 HEL-S-30 ENO1 PKLR HK3 HEL-S-32 HEL-S-281 HEL-S-49 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260610%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MLPH RPH3A MADD SYTL1 MYRIP SYTL5 UNC13D RAB27B TBC1D10A SYTL2 EXPH5 RAB27A MAPK SIGNALING%WIKIPATHWAYS_20260610%WP382%HOMO SAPIENS MAPK signaling MAPK10 TGFBR2 RPS6KA5 MAPKAPK2 DKFZp686L0365 TNF CACNA1H PLA2G4B PPP3CC PRKACG TRAF2 RPS6KA4 FGF8 IL1R2 MAP2K3 CACNA2D3 CACNA2D2 CACNA2D4 TRAF6 MAPK8IP2 MAPK8IP3 MAPK8IP1 CACNB1 CACNB3 CACNB4 DDIT3 MAPKAPK5 CACNA1B NTRK1 CACNA1A JUND STK4 NGF NLK CACNA1F RASGRP4 MAP2K6 GNG12 RASGRP3 MAP3K1 CACNA1G CACNA1I FGFR4 PPP3R2 CACNA1S HSPA2 FGF16 PPP5C RASGRF2 MAP3K8 PPP3R1 LRRK2 CRKL MAP3K6 ECSIT DUSP16 MAP3K5 DUSP10 MYC DUSP4 DUSP2 MAP2K1 PLA2G4F DUSP3 MAP2K2 PLA2G4D PLA2G4E PLA2G4C HEL-S-72p RRAS2 DUSP8 CDC25B DUSP9 TGFBR1 MAP3K13 DUSP7 NTF3 MEF2C MAP3K14 PPM1B ATF2 MAP3K11 RAPGEF2 RAF1 MAP3K12 CACNG6 CACNG7 CACNG1 NTRK2 HEL-S-31 CACNG3 CACNG4 CACNG5 RAP1A MAP3K7IP1 TAOK3 TAOK1 CACNG8 pk ATF4 PDGFA JUN MAP4K2 PTPN5 HSPA1A CACNG2 GADD45A FGF13 MAPK9 GRB2 FGF12 MAPK7 MAP4K3 MAP3K2 IL1R1 CACNA2D1 MAPK12 MAPK13 MAPK11 BDNF CASP3 HRAS NTF4 MAP4K1 RAC1 FOS RASA2 TAOK2 SOS1 FGF3 CRK FGF4 RELB FGF6 CDC42 FGF7 FGF9 FLNA FLNB IL1B MAPK8 PAK1 MAPK1 FGF20 FGF22 MAPK3 FGF21 FGF17 EGFR ARAF FGF14 IKBKB AKT3 RRAS FGF19 MAPK14 FGF18 IKBKG LAMTOR3 CHUK FGF10 SOS2 RELA CD14 FGF2 MAP2K4 NFATC3 FGFR2 NFATC1 PRKCA PPP3CA EGF MAP2K5 NF1 FGFR1 RASGRF1 NRAS NFKB1 NFKB2 RAC3 CACNA1C FGF23 FGFR3 TGFB1 MAP3K7 HEL-S-102 IL1A TNFSF6 MAPKAPK3 SMIM40 MAX TNFRSF1A HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260610%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260610%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 REL MYD88 IKBKE RELB TLR4 MAPK1 NFKB1 NFKB2 IKBKB TBK1 IKBKG CHUK TICAM2 IRAK4 TICAM1 TIRAP TLR9 IRF3 TLR8 TLR5 RELA TRAF3 TLR3 TRAF6 IRF7 TLR7 TLR1 IRAK1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260610%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction BMPR1A TNFRSF14 CXCL6 CXCL9 CSF2 CXCL8 CXCL17 CXCL1 CXCL13 CXCL3 CXCL2 TNF CXCL5 CCR6 IL6ST IL6R IL10 IFNAR2 IL1R2 IFNAR1 IL8RB IL9 IL9R CCL5 CCL4 CCL3 CCL2 IFNB1 PPBP IL6 CXCL11 MSTN CXCL12 PF4 IL13RA1 TGFBR1 LEPR CNTFR IL4 CNTF IL23R IL27RA IFNA2 TNFSF10 gdf7 ACVR1 IL15RA IL20RA IL20RB CCR10 PRL CCR1 XCR1 TNFSF14 TSLP TNFSF12 LIF GHB2 GDF1 IFNLR1 GDF3 GDF6 CSF3 GDF5 CSF3R IL22RA1 CD27 EPO NODAL ACVRL1 IL22 IL20 TNFRSF13B IL26 IL24 IL27 ANP32B TNFRSF13C CX3CL1 PRLR CCR8 CCR7 CCR5 CCR4 PF4V1 CCR2 CXCR4 IL11 TNFRSF12A IFNGR1 IFNGR2 IL19 IL17RC IL17RB GH1 IL17RA CCL14 CCL13 CCL11 IL7 CXCR5 CXCR6 CXCR1 TNLG7A IL7R CCL19 CCL18 IL12RB1 RELT GHR CCL15 GDF10 CCL25 IL33 CCL24 CCL23 IL31 CCL22 CCL21 IL3RA IL10RB ACKR3 IL10RA IL34 BMP8B CLCF1 TNLG8A INHA CCL27 IL18R1 CCL26 AMHR2 CCL4L2 EPOR MPL CXCL14 IL-21 CXCL16 IL18RAP TNFRSF8 IL13RA2 TNFRSF4 TNLG5A IL11RA TNLG2B CSF2RB CSF2RA TNFRSF17 TNFRSF9 TNFRSF10C INHBB TNFRSF10A INHBC IFNW1 BMP6 INHBE BMP3 BMP10 BMP15 AMH TNLG1B TNFRSF18 TNFRSF19 IFNK LTA XCL2 XCL1 TNFRSF25 LTB TNFRSF21 CX3CR1 IL1RL1 IFNL2 CCL8 IFNL1 ACVR1C CCL7 IL21R CCL1 IFNL3 ACVR2B ACVR2A ACKR4 TNFSF11 TNFRSF11B TGFBR2 ACVR1B IL1RN CSF1 IL36A IL36B IL23A IL1RL2 IL36RN IL37 IL36G IL2 IL1F10 NGF LTBR TNLG7C INHBA EDAR TNFRSF10B IL1R1 TNFRSF11A IL18 NGFR IFNG CCR3 GDF15 CSF1R TPO IL3 LEP CD40 IL5RA IL2RG TNFRSF1B IL5 CD40LG BMPR2 IL2RA IL2RB IL25 GDF11 CCL20 IL13 TGFB1 IL17F IL17D IL17C CCL28 BMP7 IL17B IL17A BMP5 BMP4 IL1A TNFSF6 TNFRSF1A REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260610%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IFNLR1 MAPK10 CSF3R IL22RA1 DEPTOR MAPK8 AKT1S1 MAPK1 RICTOR MAPK3 TRIM28 IFNGR1 CTF1 IFNGR2 EGFR STAT3 IL6ST MAPK14 MTOR IL7R SETD7 IL6R GHR IFNAR2 TYK2 IL3RA IL10RB IFNAR1 IL10RA PDGFRA SOCS3 CREBBP JAK3 IL9R SRC MPL PTPRC PRKCB IL11RA CSF2RB CSF2RA DUSP2 MAPKAP1 MLST8 IL5RA IL2RG IL2RA IL2RB IL21R MAPK9 CNTFR MAPK7 PTPRT MAPK6 AGTR1 MAPK4 IL27RA AGTR2 MAPK15 F2RL3 IL15RA F2R OSMR RPTOR IL20RA MAPK12 IL20RB MAPK13 MAPK11 JAK1 F2RL2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260610%WP4565%HOMO SAPIENS Neural crest cell migration in cancer PIK3CA PIK3R4 MMP2 PIK3R3 ARHA PAK1 TWIST1 SORT1 NTRK2 KIDINS220 STAT3 AKT3 TIAM1 JUN PIK3CD PAK6 PAK4 EPHB6 TRIO PIK3R5 EPHB2 ARF1 EPHB1 EPHB4 EPHB3 NGFR BDNF CDH11 F2RL2 MMP9 RAC1 FOS INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260610%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB HEL-S-71 TIFA NFKB1 UBE2V1 AJUBA PRKCZ SQSTM1 IL1A IRAK1 TRAF6 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260610%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy HDAC5 RCAN1 CDK7 PIK3CA PLCB2 ARHA MAPK8 MAPK1 CAMK2D MAPK3 CTF1 TNF STAT3 IKBKB IL6ST MAPK14 IKBKG MTOR CHUK PIK3CD MYLK3 MYLK MAP2K3 WNT3A CDK9 EDN1 FGF2 MAP2K6 IGF1R MAP2K4 PRKCB FGFR2 IKBKE PDPK1 PPP3CA EGF MAP2K5 MAP2K1 GSK3B MAP2K2 GATA4 NFATC4 PIK3R3 PIK3R2 IGF1 PIK3R1 NFKB1 MAP3K14 RAF1 NRG1 MAP3K7IP1 ROCK1 ROCK2 MYEF2 MAPK7 TGFB1 CALM1 MAPK4 LRP5 NPPB LRP6 NPPA PRKG1 CISH HDAC7 DVL1 FZD1 EIF2B5 RAC1 FZD2 LIF PLA2G2A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260610%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis FAAH TRPA1 HTR1A TRPV1 KCNQ2 KCNQ3 PTGS2 CACNA1H PTGS1 VISUAL CYCLE%WIKIPATHWAYS_20260610%WP5534%HOMO SAPIENS Visual cycle RDH10 RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 OPN1LW RBP3 RDH11 RBP1 RHO RDH5 LRAT SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260610%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis GDI1 RPH3A STXBP1 UNC13A VAMP2 NAPA SYT1 SYP CPLX1 STX1B RIMS1 CACNA1B STXBP5 CACNA1A STXBP6 SNAP25 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260610%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR ABRAXAS1 BRCC3 TRIM28 DCLRE1A MDC1 SMARCAL1 FEN1 UBE2D3 CEP164 HERC2 MRE11A TOPBP1 RMI1 IKBKG TOP3A RECQL RAD50 HUS1 EEF1E1 MCPH1 XPA RNF8 PPM1D RECQL4 BRIP1 WRN RBBP8 CLSPN TP53BP1 POLN XRCC5 SHFM1 USP1 FANCA PALB2 CLK2 BCL6 RFWD3 TDP1 BRCA2 CHEK2 CHEK1 H2AX PCNA SMARCC2 CDC45 MSH2 NBN RPA1 SMC1A PRKDC FANCD2 BARD1 PLK1 ATRIP CDC2 SP1 UIMC1 PML CDK2 RAD52 MDM2 RAD51 ATM RAD17 ATR FOXM1 RAD1 MCM2 RAD9A BRCA1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260610%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation RASA2 GNA13 IKBKB IKBKG CHUK RELA TRAF6 VAV1 ZAP70 LCK SOCS1 ITK DGKA TNFAIP3 TMEM222 GRAP2 ARIH2 UBASH3A DGKZ PLCG1 REL LCP2 PTPN6 CARD11 PDPK1 NDUFB10 CD3G CUL5 PRKCQ RNF7 CD3E MAP3K8 BCL10 RPRD1B CD8A SH2B3 MEF2D SH2D1A ARHH FIBP CD5 AGO1 LAT PIK3R2 PIK3R1 NFKB1 MAP3K14 NFKBIA GRB2 CDKN1B CD3D MAP4K1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260610%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK2 PCSK1 GCG GLP1R INS REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260610%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds CSNK1A1 LEF1 GSK3B TNKS FZD7 AXIN1 MBOAT1 FZD8 DKK3 SFRP4 APC DVL2 FZD1 TCF4 WNT1 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome HDAC8 APC CDCA5 SMC1A PDS5B PPP2R1B PDS5A AURKB PPP2R1A NIPBL SGOL1 PPP2CA PTTG1 WAPAL ESCO1 PLK1 ESCO2 REC8 CDC2 SMC1B MAU2 STAG2 PPP2R5E STAG3 PPP2R5B ESPL1 PPP2R5A PPP2R5D PPP2R5C PTPA SMC3 RAD21 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260610%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260610%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 SDHA COA3 AS3MT HEL-S-21 UQCRFS1 ND1 HEL-S-44 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260610%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 DDC DRD2 CHRNB2 CDK5 TH CHRNA3 KCNK9 CHRNA5 CHRNA6 GNG2 PPP1R1B DRD3 SLC18A2 DRD4 KCNK3 GNAI1 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases DPYS HEL74 OTC TYMP CAD ABAT RRM1 RRM2 DPYD DHODH UMPS AGXT2 TYMS NT5C3A RRM2B GLS2 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260610%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer PIK3CA SOS1 DEPTOR MAP2K1 MAPKAP1 MAP2K2 PIK3R1 TSC2 TSC1 NRAS MAPK1 AKT1S1 RICTOR MLST8 MAPK3 RAF1 ARAF AKT3 EIF4EBP1 MTOR SOS2 IRS1 GRB2 PTEN RPTOR HRAS PARP2 INPP4B RPS6KB1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling MAML2 NOTCH4 NOTCH2 RBPJ JAG2 CHUK DLK2 NOTCH1 DNER MFAP2 MAML3 DLL3 DLL4 PSEN2 PSEN1 LEF1 HES1 MAML1 ADAM10 MFAP1 NOTCH3 RRAS PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260610%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 STAR BAX HEL-S-2a HSD3B2 CASP3 PARP2 CYP11A1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260610%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence MDH2 HMGA1 GOT2 IL6 SIRT5 NMNAT2 ELAVL1 SIRT2 SIRT3 RELA NAMPT IL1B PRKAA1 SLC2A4 CCL27 SIRT1 HEL-S-32 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation IFT74 CREB1 RMND5A PRKAA1 RANBP9 MKLN1 NR1H2 GID4 TNF RMI1 TOP3A CLUAP1 BCL2L11 BCL6 FOXA1 HEL-S-133P APP MYC PRKAB1 TRAF3IP1 PCK1 G6PC1 HES6 MAP3K14 BLM RRAGA PRKAG2 JUN MYH2 CDC2 COPS8 CLTC CLTB PTEN CLTA NR1H3 RPTOR IFT172 MYD88 MAEA IFT80 ARMC8 ITPK1 TNFRSF13B IFT81 ATG101 FHOD1 IL1B PARK2 ARHA FERD3L IRF8 ALKBH5 CFL2 DENR MIGA1 MED9 RNF41 TOM1L2 COPS7A PARD3 LLGL1 DRC5 DRC7 DRC8 FLII STAT3 GPR85 CLEC16A PLD6 RAI1 WWTR1 MTOR TNFSF13 RAB39B BAX PEMT DRC1 GDI2 WDR41 FLCN ATPAF2 ARG2 RMI2 DRC10 RELA SMCR8 COPS4 C9orf72 IFT20 GPS1 COPS6 MIEF2 IFT22 PARD6B RASD1 COPS5 FNIP1 FNIP2 PPP1R14A LIMK1 MYO16 RAB10 IFT27 MYO15A CARM1 IFT25 PER1 DRG2 FOXA2 TTC26 PRKCI CRY2 CRY1 SHMT1 IFT52 IFT57 TLR4 RAB8A NFKB1 RB1CC1 MLST8 TFEB ULK1 BIRC2 ROCK1 GRIP1 IFT46 ETV5 YAP1 IFT70B WDR26 G13 SIGNALING%WIKIPATHWAYS_20260610%WP524%HOMO SAPIENS G13 signaling WAS MAPK10 CYFIP1 WASL PKN1 SH3RF1 PIP4K2A PIK3CA RHPN2 MYBPH CIT MYL1 PFN1 CDC42 TNK2 HEL-S-15 ARHA PIK3R2 GNA13 CFL2 IQGAP1 ROCK1 ROCK2 ARHGEF1 PIK3CD CALM1 ARHGDIB HEL-S-80p LIMK1 RTKN RAC1 ARHGDIG RPS6KB1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP581%HOMO SAPIENS EPO receptor signaling EPO SOS1 PTPRU IRS1 MAP2K1 MAP2K2 GRB2 SHC1 STAT5B MAPK1 SOCS1 MAPK3 SRC RAF1 CISH STAT1 STAT3 EPOR PTPRC SPINAL CORD INJURY%WIKIPATHWAYS_20260610%WP2431%HOMO SAPIENS Spinal cord injury NTN1 EGR1 CXCL8 CXCL1 CXCL2 TNF PLA2G5 EPHA4 IL2 ACAN SOX9 FKBP1A EFNB2 CCL2 RB1 IL6 CCND1 MYC MMP12 CDC2 GADD45A CDK4 CDK2 IL4 CDKN1B IL1R1 GRIN1 NGFR BDNF CASP3 IFNG RHOB HEL113 RAC1 FOS PLA2G6 CDC42 IL1B ARHA MAPK1 CCR2 MAPK3 EGFR MBP TNFSF13 TNLG7A GJA1 COL4A1 MMP9 CCNG1 PRKCA PPP3CA XYLT1 AQP4 AQP1 ZFP36 SEMA6A OMG PDYN BCAN RTN4R KLK8 CHST11 PLXNA2 TLR4 GFAP SELP NOX4 CSPG4 FOXO3A BTG2 LEP NCAN PRB1 PRB2 ANXA1 RGMA COL2A1 VCAN ROS1 GAP43 LTB CD47 C1QB AIF1 SLIT1 SLIT3 NOS2 ROCK2 SLIT2 E2F5 RTN4 LILRB3 FCGR2A APEX1 ARG1 TGFB1 TACR1 IL1A PTGS2 GDNF LTB4R PLA2G2A IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260610%WP2007%HOMO SAPIENS Iron metabolism in placenta HAMP SLC11A2 HEL60 TF HEPHL1 TFRC STEAP3 TFR2 IREB2 SLC40A1 MCOLN1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling PDHA1 EPO HEL-S-133P HEL-S-68p PFKL TGFA HIF1AN BIRC5 BNIP3 SLC2A3 PMAIP1 NOS2 BAX BCL2A1 BAK1 EGLN1 IGFBP1 BNIP3L IGFBP2 ANGPT1 HEL-S-30 EDN1 ANGPT2 HIF1A PTGS2 VEGFA BCL2L1 MCL1 LAC PHE PATHWAY%WIKIPATHWAYS_20260610%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260610%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis SCD FASN FADS2 ELOVL5 FADS1 ELOVL1 ELOVL2 SCD5 ELOVL3 ACSL1 ELOVL6 FACL4 ACSL3 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260610%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection WAS TUBA3E WASL TUBA1C TUBB6 TUBA1B TUBA1A PRKCA EZR HEL-S-93 TUBB1 TUBB ARPC4 CDC42 ARPC5 HEL-68 TUBB4B TUBB4A TUBA4A ITGB1 TUBB2A YWHAQ KRT18 ARHA ARPC2 ARPC3 NCK2 TUBA2 NCK1 HCLS1 ARHGEF2 TLR4 TUBA8 NCL ROCK1 ROCK2 CLDN1 TLR5 ACTG1 CD14 PS1TP5BP1 FYN TUBAL3 ARPC1B LY96 TUBB8 SLC25A46 PATHWAY%WIKIPATHWAYS_20260610%WP5521%HOMO SAPIENS SLC25A46 pathway EMC1 EMC2 EMC3 MFN1 MFN2 EMC6 EMC7 OPA1 APOOL MMGT1 IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 CHCHD6 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260610%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1 ACAT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260610%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides SPHK1 SGMS2 UGCG DES KDSR CERS3 CERS5 SPTLC1 CERS2 CERS6 DGAT1 CERK SGMS1 LASS1 UGT8 B4GALT1 B3GNT5 B4GALNT1 A4GALT A3GALT2 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3CA PIK3R4 GSK3B MAPKAP1 PIK3R3 STK11 PIK3R2 PIK3R1 TSC2 FOXO1 TSC1 RICTOR MLST8 AKT3 IKBKG MTOR PIK3CD ATM PIK3R5 PARP3 RPTOR PHLPP1 PIK3C2G SIRT1 PARP2 PIK3C2B 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAP RB1 TRAF2 MAP3K5 ATG16L1 ATG101 GABARAPL2 RB1CC1 PTK2B WDR45B GABARAPL1 ULK1 TNF PDGFR BETA PATHWAY%WIKIPATHWAYS_20260610%WP3972%HOMO SAPIENS PDGFR beta pathway MAP2K4 PRKCB PLCG1 JUN PIK3CA PRKCA SOS1 EIF2AK2 MAP2K1 GRB2 SHC1 MAPK8 STAT5B PIK3R1 MAPK3 RAF1 HRAS STAT1 JAK1 MAP3K1 STAT3 FOS T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260610%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PIK3CA SOS1 PAK1 CSF2 MAPK3 TNF CTLA4 IKBKB RRAS IKBKG CHUK IL10 IL2 ZAP70 LCK PDCD1 CBL CHP1 AHSA1 ITK FYN ICOS GRAP2 PTPRC PLCG1 LCP2 PTPN6 CARD11 NFATC2 PRKCQ MAP3K8 BCL10 CD8A MAP2K1 GSK3B MAP2K2 LAT NCK1 NFKB1 MAP3K14 RAF1 DAG1 IL5 CD40LG JUN CDK4 MAPK9 IL4 NFKBIA GRB2 CALM1 MAP3K7 CD3D IFNG FOS GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260610%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCB RCAN1 PPP3CC PPP3R2 PRKCI PKN1 PRKCH PRKCE NFATC1 PRKCA PLCB3 PKN2 PRKCQ PRKCZ PPP3R1 PRKD3 PPP3CA PRKD1 ANGPT2 PKN3 PRKD2 NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP61%HOMO SAPIENS Notch signaling MAML2 CIRSR NOTCH4 SKP1 RBPJ HES5 SPEN JAG2 RING1 NOTCH1 ITCH SNW1 PSENEN MAML3 DLL3 DLL4 PSEN2 SAP30 PSEN1 GSK3B PIK3R2 HES1 PIK3R1 NFKB1 HES6 NCOR2 NCOR1 STAT3 ADAM17 NOTCH2 MTOR EP300 MAML1 FBXW7 LCK HDAC2 NUMB SRC FHL1 HDAC1 DTX1 APH1B HEY2 NOTCH3 MAGEA1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260610%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PRKCB PRKCH PIK3CA PRKCA PLCB3 PLCB4 PRKCQ KISS1R KISS1 FSHR PLCB1 MAP2K1 PLCB2 MAP2K2 NRAS MAPK1 NFKB1 BMP15 AMH MAPK3 DKFZp686L0365 RAF1 HSD3B1 CYP11A1 STAR PRKCE PIK3CD HRAS MMP9 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260610%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis MTOR EIF4A2 PRKAA2 CSN3 EEF2K PRKAB2 CSN2 CSN1S1 EEF2 PRKAB1 EIF4G1 PRKAA1 TSC2 RPTOR MLST8 EIF4E PRKAG1 PRKAG2 PRKAG3 RPS6KB1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260610%WP2361%HOMO SAPIENS Gastric cancer network 1 TOP2A NOTCH1 INO80D NUP107 UBE2C H4C9 HCTP4 H3F3B LIN9 GATD3 AURKA KIF15 SMOC2 CENPF ESM1 RUVBL1 APC S100P CEP192 MYBL2 ECT2 ACTL6A KIF20B E2F7 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260610%WP4255%HOMO SAPIENS Non small cell lung cancer RARB PIK3CA SOS1 KIF5A RXRA MAPK1 E2F3 MAPK3 EGFR BAD ARAF CDKN2A STAT3 AKT3 BAX SOS2 PIK3CD STAT5B JAK3 STK4 PRKCB PLCG1 PDPK1 PRKCA RB1 RASSF1 CCND1 ERBB2 EGF PLCG2 MAP2K1 MAP2K2 TGFA HGF E2F2 NRAS FOXO3A RAF1 DDB2 ALK RET POLK HEL-S-61 EML4 CRABP2 CRABP1 FHIT RXRB GADD45B RXRG GADD45A CDK4 GADD45G CDK6 GRB2 BAK1 CYCS CDKN1A CASP9 CASP8 CASP3 HRAS 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260610%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb COX5A NDUFA9 PRKAA1 MAPK1 MAPK3 CDR2 MAPK14 MTOR POLR3E RPS6KB1 RPS6KA1 EEF2K PRKAB2 MAP2K1 PRKAB1 EEF2 MAP2K2 MLST8 PRKAG1 PRKAG2 PRKAG3 CDC2 COX7C CYB PRKAA2 RAB5IF MOSMO CDK2 NDUFS8 UQCRC1 UQCRFS1 NDUFS3 COXFA4 CALM1 UQCRC2 CDH18 UQCRB UQCR11 UQCR10 UQCRH RPTOR TRPM7 MAPK12 CYC1 MAPK13 PDZD9 MAPK11 SDR42E2 VWA3A UQCRQ NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260610%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer REL PECAM1 TGFBR2 RELB EGF MMP2 MAP2K1 COL1A1 MAP2K2 COL1A2 HGF PLXNA2 MAPK1 NFKB1 TGFBR1 NFKB2 MAPK3 NRP1 GSK3A EGFR CCNE2 AKT3 CCNE1 SMAD2 CDK2 RELA CTGF SNAI1 SNAI2 CDKN1B FLT1 CHD2 SRC SMAD4 SEMA3A MMP9 PLXNA1 VEGFA KDR RAC1 PLXNA4 TGFBR3 GASTRIN SIGNALING%WIKIPATHWAYS_20260610%WP4659%HOMO SAPIENS Gastrin signaling EGR1 CREB1 ITGB1 CXCL8 TJP1 DKFZp686L0365 IRS1 PRKD1 IL2 FYN PRKD2 BCL2L1 RPS6KB1 CCND1 MEF2D MYC MAP2K1 MMP7 SHC1 MEF2C ATF2 MAP3K11 RPS6 RAF1 PXN EIF4EBP1 PRKCE JUN SP1 CLDN1 MAPK9 NFKBIA GRB2 CDKN1A CDKN1B CASP3 HRAS RHOB RAC1 FOS KAT5 MEF2B ARHGEF28 PIK3CA YES1 SERPINB2 SOS1 ANXA2 CRK RHOD CD44 CDC42 HDC ELAVL1 KLF4 ARHA MAPK8 PAK1 MAPK1 MAPK3 CCKBR EGFR BAD CDKN2A TCF4 STAT3 IKBKB PTPN11 MAPK14 MTOR LAMTOR3 CHUK KIT RELA SRC VEGFA PLCG1 PRKCH PRKCA PRKCQ GAST GSK3B PIK3R3 PIK3R2 PIK3R1 BIRC5 FOXO1 SLC9A3 NFKB1 FOXO3A PPARG BIRC2 BIRC3 ROCK1 BMP2 HDAC7 PTGS2 TFF2 BURN WOUND HEALING%WIKIPATHWAYS_20260610%WP5055%HOMO SAPIENS Burn wound healing PECAM1 S100A9 MYD88 KLF4 FOXE1 HEXD F13A1 KRT222 IL1B S100A6 PCTK1 FLG TAGLN BRD4 AMBP CXCR4 HEL-S-43 CXCL8 SLURP1 LIN28A TPT1 CXCL1 FBN1 TNF BAX TNC HMGB1 ACHE IL8RB CCL2 MMP9 INHBA VEGFA FGFR4 IFNB1 FGFR2 CD3E IL6 EGF MMP2 CXCL12 MMP28 COL1A1 FGFR1 COL1A2 HGF TLR4 NFKB1 NOX4 CHRNA7 FGFR3 SCEL BCL2 KRT6A SNAI2 IFNA2 FST DCN CASP3 ACTA1 TIMP1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome CRY2 ITGA6 HBEGF REST HLA-DMA HLA-DMB CD63 ITGB1 ITGA4 NRXN1 LGALS3BP IGSF8 CD151 CD82 SPPL2C PRDM11 ACCS PHF21A ALKBH3 C11orf96 ALX4 TP53I11 GLI3 LARGE2 CD19 PEX16 CHST6 SHH IZUMO1 SLC35C1 SYT13 LEF1 EXT1 VANGL1 EXT2 FREY1 SLC25A17 MAPK8IP1 B4GAT1 B3GNT7 PEX3 TSPAN18 CHST1 MS4A1 B4GALT4 SDCBP TIMP1 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260610%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260610%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization IL5 CD40LG CCR3 IL12RB1 IL12B IL12A IL2 IL4 TGFB1 CCR7 CCR5 CCR4 CSF2 CXCR4 CCR2 IFNGR1 CCR1 IFNGR2 CCL4 CCL3 IL18R1 IFNG CXCR3 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260610%WP4753%HOMO SAPIENS Nucleotide excision repair GTF2H2C_2 LIG1 CDK7 RFC2 GTF2H2 POLE GTF2H3 GTF2H4 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 ERCC2 ERCC5 MNAT1 PCNA RPA1 RFC1 RPA3 DDB2 POLD3 POLD4 POLD2 CUL4B XPA POLE4 POLE2 POLE3 CCNH CETN2 XPC POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP2571%HOMO SAPIENS Polycystic kidney disease pathway CFTR GNAS VEGFB STK11 PRKAA1 MAPK3 DVL3 SLC12A2 TNF IKBKB GNAI1 PRKACG MTOR PDE1A WNT3A GNAI3 ADCY6 FLT1 SRC IGF1R KDR RPS6KA1 CCND1 ERBB2 EGF PLCG2 MYC PRKAB2 GSK3B PRKAB1 WNT2B MAP2K2 FZD10 PKD1 IGF1 WNT5B WNT9B TSC2 TSC1 WNT9A WNT16 NRAS FZD7 WNT8A WNT8B KCNN4 FZD8 WNT3 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 PRKAG1 FZD5 PRKAG2 FZD4 PRKAG3 WNT7B FZD9 WNT7A JUN GNA11 RHEB PRKAA2 HRAS SSTR2 DVL1 FZD1 WNT1 FZD2 FOS ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260610%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk ROBO4 SLIT2 SRC VEGFA KDR RAC1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAVIN1 PIK3CA BSCL2 HMFN0839 LPIN2 LPIN3 IRS1 INS DGAT1 GRB2 ITGB4 FYN LPIN1 HIF1A DGAT2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260610%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK10 NFYA AXIN2 CD44 ARHA CTBP2 APC DVL3 NR1C2 EP300 PPP2R5E PRKD1 LDLR LEF1 PPP2R5C WNT3A PTPA TCF7L2 TCF7L1 hCG_2014051 CREBBP NLK PPP2R3B PPP2R3A FOSL1 PPP2R2C PPP2R2B MAP2K4 PRKCB PRKCI PRKCH PRKCA PRKCQ LRRK2 PRKCZ CCND1 MYC SOX2 GSK3B WNT2B FZD10 MMP7 WNT5B WNT9B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 PPP2R2A WNT4 DVL2 WNT10B WNT10A PPP2R1B FZD3 FZD5 PPP2R1A FZD4 WNT7B FZD9 PPP2CA WNT7A PRKCE JUN CTNND1 FRAT1 FOXD3 ZBTB33 CTBP1 PPM1J MAPK9 NKD1 NKD2 ESRRB PAFAH1B1 LRP5 MAP3K7 LRP6 POU5F1 DVL1 FZD1 WNT1 FZD2 NEPHROGENESIS%WIKIPATHWAYS_20260610%WP5052%HOMO SAPIENS Nephrogenesis NOTCH2 FGF8 SIX2 WNT3A FOXD1 OSR1 WNT9B GREB1L BMP7 TCF21 MEIS1 PAX2 ALDH1A2 FGF20 RSPO3 RSPO1 WNT4 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260610%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ROCK1 NR1i1 CYP3A4 ACE2 REN IL1B CPN1 ARHA AGTR1 AGTR2 MAPK1 NFKB1 CYP24A1 KLK1 PRKG1 KNG1 IL1A BDKRB2 BDKRB1 TNF SERPING1 KLKB1 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260610%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL12RB1 IL22 IL12B TYK2 IL17F STAT5B TLR4 CSF2 IL17A STAT4 STAT1 IFNG IL23A STAT3 TNF RORC HEROIN METABOLISM%WIKIPATHWAYS_20260610%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260610%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins HEL-S-310 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL13a RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS3A RPSA RPL37A RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 MRPL19 RPL11 RPL36A RPS4Y1 RPS6KB2 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPS27A RPS6KB1 RPL17 RPL19 RPS6KA6 RPL41 RPL35A RPS6KA2 RPL23A RPS6KA1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPS6 IL2 SIGNALING%WIKIPATHWAYS_20260610%WP49%HOMO SAPIENS IL2 signaling SOS1 CRKL MAP2K1 MAP2K2 SHC1 NMI PIK3R1 MAPK1 PTK2B MAPK3 FOXO3A RPS6 RAF1 STAT1 IL2RG STAT3 PTPN11 IL2RA IL2RB IL2 GRB2 GAB2 STAT5B LCK SYK CBL SOCS3 JAK3 RPS6KB2 FYN HRAS CISH JAK1 RPS6KB1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260610%WP1993%HOMO SAPIENS Angiogenesis overview SOS1 CRK CDC42 PLXND1 MAPK8 PAK1 MAPK1 PTK2B IQGAP1 BAD APC PTPN11 MAPK14 MTOR PIK3CD VHL ANGPT1 SRC MMP9 MAP2K6 VEGFA KDR MAP2K4 WAS PLCG1 PDPK1 PRKCA FRS2 MMP2 MAP2K1 FGFR1 TIMP4 SHC1 SHB NCK1 ROBO1 GRB14 MMP14 GRB7 PLA2G1B NOX4 BMX ATF2 RAF1 NRP1 PXN DAG1 ROBO4 SLIT2 GRB2 MAP3K7 F2 MAPK11 SEMA3A RAC1 GLUCURONIDATION%WIKIPATHWAYS_20260610%WP698%HOMO SAPIENS Glucuronidation UGT1A4 UGT2B4 PGM2 UGT1A3 PGM5 UGT2A2 UGT1A1 UGT2A1 UGT2B7 UGT1A9 UGT1A8 UGT1A7 UGT1A10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGDH UGT1A5 PGM3 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 S1PR1 BTK MS4A1 HEL-S-171mP S1PR3 S1PR5 S1PR4 ITGB1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway CYP1A2 UGT1A1 NQO1 SERPINB2 CYP1A1 CYP1B1 NCOA1 IL1B HES1 NFE2L2 SLC7A5 EGFR TNF UGT1A4 POLK UGT1A3 CDC37 JUN EP300 BAX UGT1A9 MGST1 UGT1A7 AHR IL12B IL12A CAP2 PTGES3 MYOF IL2 TGFB1 AIP ALDH3A1 AHRR IGFBP1 CES3 CDKN1B JUNB IL17B JUND SRC IFNG METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer PDHA1 GOT2 HEL-S-133P GPT RPIA GLUD1 PFKL SLC7A5 GNPNAT1 GLS2 PGM3 ACLY HMGCR FASN HK2 LDLR DLAT GFPT1 SOAT1 RPE SLC16A4 DLD PDHX CS BCAT2 HEL-S-30 CARM1 HEL-S-32 ME1 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260610%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP1A2 ALOX15 GPX4 CYP4A11 CYP3A4 EPHX3 ALOX12B PTGS2 ALOXE3 CYP2C19 PTGS1 CYP2C9 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260610%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K4 MTOR PIK3CA MAP2K5 MAP2K3 MAP2K1 MAP2K2 ARHA TRIO MAPK1 NFKB1 YAP1 MAPK3 RAF1 MAP2K6 AMOT RAC1 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260610%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway TYROBP PLCG1 PTPN6 LCP2 CD34 PRKCA PRKCQ GRB2 LAT VAV1 SYK CSF2 HLA-C FYN HRAS IFNG TNF KIR2DL1 RAC1 KIR2DL3 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260610%WP1471%HOMO SAPIENS Target of rapamycin signaling PRR5 DDIT4L PRKCA DDIT4 CDC42 PRKAB2 PRKAB1 ULK2 MAPKAP1 PRKAA1 TSC2 TSC1 AKT1S1 RICTOR MLST8 ULK1 RRAGA PRKAG1 RRAGB PRKAG2 RRAGD PRKAG3 EIF4EBP1 MTOR HMGCR RHEB PRKAA2 RPTOR FKBP1A RAC1 RPS6KB1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260610%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MTOR SIRT6 SCD HMGCR MED15 FASN SREBF2 LDLR ABCA1 PRKAA1 HMGCS1 NR1H3 PPARGC1A NR1C1 SIRT1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260610%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260610%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-87p PFKM HEL-S-133P HEL-S-68p GPT HEL-S-30 ENO1 HEL-S-162eP PGAM2 HEL-S-49 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260610%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A MAOA IL1R1 TGFB1I1 ITGB3 TPH2 IL1B MACROPHAGE MARKERS%WIKIPATHWAYS_20260610%WP4146%HOMO SAPIENS Macrophage markers LYZ CD74 CD163 CD83 CD68 F3 CD14 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma SOS1 IL6 CCND1 CD44 MYC FRZB HNF1A HEL-117 MAPK8 BIRC5 E2F2 NFKB1 TGFBR1 CXCL8 MAPK3 STAT3 PTPN11 MAPK14 BIRC3 CXCR1 JUN NOS2 IL6R LEF1 RRM2 MYOF GRB2 TGFB1 CDKN1A BRCA1 COL4A2 CASP9 CASP3 SMAD4 HIF1A JAK1 TNFSF6 PTGS2 VEGFA RAC1 VAV2 BCL2L1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260610%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 SDHB SUCLG2 ACO2 SDHC SDHD SDHA SUCLA2 OGDH IDH3B SUCLG1 DLD CS FH TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260610%WP5130%HOMO SAPIENS Th17 cell differentiation pathway IRF4 IL22 HLA-DMA IL27 IL1B MAPK8 RXRA MAPK1 FOXP3 NFIL3 TBX21 IFNGR1 NR1D1 STAT1 IL23A STAT3 IKBKB MAPK14 MTOR RUNX1 GATA3 IL6R TYK2 IL2 ZAP70 LCK SOCS3 HIF1A PER1 IL-21 PLCG1 CRY1 NFATC1 CD3G PRKCQ CD3E IL6 PPP3CA RORA LAT TGFBR1 NFKB1 SMAD2 IL2RA JUN IL21R AHR IL4 NFKBIA TGFB1 IL23R IL17F IL27RA IL17A CD3D JAK1 IFNG RORC FOS RARA FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260610%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma BCOR SUZ12 H3C15 H2AX H3C8 H3F3B MAPK1 H2AZ1 EED BCL6 MAPK3 H2AZ2 H2AB3 H2AB1 MACROH2A2 RNF2 H2AJ PCGF1 EZH2 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260610%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria COX5A COX7A1 COX3 SDHC NDUFA9 SDHD NDUFA5 NDUFA13 NDUFA11 NDUFA12 ATP5G1 COX6A2 HEL-S-271 ATP5IF1 NDUFC2 NDUFC1 COX7A2L NDUFS6 NDUFS5 NDUFS4 NDUFS1 COX17 ND3 ND2 COX11 SLC25A14 ND5 SLC25A6 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 ATP8 NDUFB5 SCO1 NDUFB4 NDUFB3 ATP6 ATP5MC2 NDUFB2 UCP1 ATP5J NDUFB10 NDUFB1 ATP5MC3 COX7A2 ATP5H HEL-S-123m SDHB SLC25A27 UCP3 UCP2 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA10 DMAC2L SURF1 NDUFA7 NDUFA6 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX6A1 COX2 COX7C COX1 CYB NDUFS8 UQCRC1 UQCRFS1 NDUFS3 COX8A ND1 COXFA4 UQCRC2 SDHA SLC25A5 UQCRB UQCR11 UQCR10 COX6B1 UQCRH UQCRQ SLC25A4 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP561%HOMO SAPIENS Heme biosynthesis UROD UROS HMBS CPOX ALAS2 ALAS1 FECH LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260610%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3L2 REL MAPK14 ATF4 IL6 IL10 RELB CREB1 RELA IL1B CD14 CREB3 TLR4 CREB5 NFKB1 MAPK12 NFKB2 MAPK13 MAPK11 CCL2 CREB3L3 CREB3L4 DOPAMINE METABOLISM%WIKIPATHWAYS_20260610%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CA MAOA PRKACG TYR NQO1 DDC TH HEL-S-44 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260610%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling WASL TNLG5A MSTN HEL-S-28 DEPTOR ITGB1 GSK3B PRKAB1 MAPKAP1 IGF1 EIF2B2 AKT1S1 NFKB1 RICTOR PPARGC1A MLST8 SMAD2 MTOR TRIM63 IGFBP5 FBXO32 IRS1 ACVR2B PTEN RPTOR EIF4E MAP1LC3A IGF1R TNFRSF1A RPS6KB1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260610%WP4595%HOMO SAPIENS Urea cycle and associated pathways MDH2 SLC25A12 NOS2 GOT2 OTC ASL NAGS GPT SLC25A13 ASS1 GLUD1 ARG1 SLC25A15 FH HEL-S-32 HEL-S-281 GLS2 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS1 GPHN AOX1 MTARC2 XDH MOCS2 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260610%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PURINERGIC SIGNALING%WIKIPATHWAYS_20260610%WP4900%HOMO SAPIENS Purinergic signaling GNAS PANX1 GNAO1 GNAI1 GNA11 P2RY8 GNAZ GNAT2 GNAT3 GNAT1 P2RY13 P2RY10 GNAI3 P2RY11 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 P2RX3 P2RY6 P2RX2 P2RY4 P2RX1 ADORA2A ADORA2B P2RY2 P2RY1 LPAR4 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260610%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 GCG IL6R IL6 GLP1R INS DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260610%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling GNB1 PDPK1 PIK3CA RPS6KA1 RB1 CREB1 PLCB1 MAP2K1 GNAS PIK3R2 GNA13 PIK3R1 CCND3 MAPK1 MAPK3 GNAO1 RPS6 RAF1 STAT1 STAT3 GNAI1 RAP1A CCNE1 MAPK14 MTOR PDE4D ADCY3 CDK4 APEX1 CDK2 MAP2K3 RBL2 GNAI3 CDKN1B GNG2 RAP1GAP SRC CGA HRAS TSHB JAK1 KCNIP3 MAP2K6 SCRIB IGF1R TSHR MYL12B RPS6KB1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260610%WP12%HOMO SAPIENS Osteoclast signaling IFNB1 TNFRSF11B CTSK TRPV5 ACP5 AIMP2 MAPK8 IFNAR1 opn TNFRSF11A ITGB3 ATP6V1G1 GPR68 TNFSF11 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260610%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH PRKCA SLC5A5 DUOX1 CLCN5 TG HEL-S-5 PRKAA2 DUOX2 CREB1 MAP2K1 TPO MAP2K2 PRKAA1 MAPK1 NFKB1 MAPK3 RAF1 CGA TSHR RAP1A ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260610%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD CYP1A2 NQO1 CYP1A1 RB1 CYP1B1 GCLC PLAGL1 MYC KLF6 MAP2K1 NF1 LPL NFE2L2 NRAS MAPK1 NFKB1 NCOR2 FGF21 RAF1 EGFR TNF CD36 RET CDC37 EP300 CCL1 AHR CDK2 RELA AIP AHRR CDKN1A CDKN1B SRC HRAS PTGS2 VEGFA 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome NIPA2 CYFIP1 FMR1 TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL6ST SOX4 IL6R NFKB1 IL11 IL6 IL11RA JAK3 JAK1 STAT3 RELA EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260610%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 SCARB1 NR1i1 NR1C1 NR1i2 CD36 NR1C2 CYP2C9 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260610%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 NFIA ERBB4 NR3C1 ERBB3 CCND1 ERBB2 MYC CSN2 EIF4G1 PRLR CEBPB YY1 DLGAP4 TFPI2 USF2 NR3A2 USF1 CLDN6 TTC9 EGFR GJB2 NRG1 GAL NFIB ORAI1 PGR HDGFL2 TPM3 CHUK CEBPA ELF5 STAT5B PTPN1 TNFRSF11A PRL EIF4E BCL2L1 TNFSF11 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260610%WP4496%HOMO SAPIENS Signal transduction through IL1R IFNB1 MYD88 IL6 ECSIT IL1B MAPK8 IL1RN NFKB1 MAP3K14 TNF IKBKB IRAK2 MAP3K7IP1 IRAK3 MAPK14 JUN CHUK MAP2K3 RELA NFKBIA TRAF6 TGFB1 IFNA1 MAP3K7 IL1R1 IL1A IRAK1 MAP2K6 MAP3K1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism hCG_1998026 B3GNT5 B3GALT2 B3GALT1 FUT1 FUT3 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260610%WP4157%HOMO SAPIENS GABA metabolism aka GHB GAD1 HEL-S-166mP GAD2 ALDH5A1 PON3 ADHFE1 ABAT GLS GLS2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260610%WP4666%HOMO SAPIENS Hepatitis B infection MAPK10 TGFBR2 HEL-S-93 CREB1 YWHAQ HEL-S-1 CXCL8 TNF TBK1 EP300 HSPG2 VDAC3 PIK3CD EGR2 IRF3 MAP2K3 DDX3X IFIH1 TRAF3 TYK2 TRAF6 IRF7 IFNAR1 JAK3 STAT4 SMAD4 MAP2K6 FADD MAP3K1 IFNB1 STAT2 IKBKE MAVS IL6 MYC RIGI MAP2K1 MAP2K2 NFATC4 PCNA TGFBR1 ATF2 RAF1 APAF1 DDB2 CREB3L3 CREB3L4 MAP3K7IP1 CREB3L2 SMAD2 ATF4 JUN TICAM2 IRAK4 TICAM1 TIRAP BCL2 IFNA5 IFNA4 TLR3 MAPK9 GRB2 IFNA7 IFNA6 CYCS IFNA1 IFNA2 CDKN1A IFNA8 MAPK12 CASP9 MAPK13 CASP8 MAPK11 CASP3 HRAS IRAK1 JAK1 CASP12 FOS MYD88 PIK3CA SOS1 IFNA13 IFNA14 IFNA16 IFNA17 MAPK8 IFNA10 MAPK1 PTK2B MAPK3 IFNA21 BAD ARAF STAT1 STAT3 IKBKB AKT3 MAPK14 IKBKG CHUK BAX SOS2 RELA CREB3 STAT5B CREB5 ATF6B CREBBP SRC MMP9 MAP2K4 PRKCB NFATC3 NFATC2 NFATC1 PRKCA DDB1 PIK3R3 PIK3R2 PIK3R1 BIRC5 TLR4 NRAS NFKB1 TGFB1 CASP10 MAP3K7 TNFSF6 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260610%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response ATF4 BCL2L11 PPP1R15A EIF2A XBP1 EDEM1 BBC3 UBE2E1 ASNS NFE2L2 HEL-S-99n DNAJC3 SULT1E1 DDIT3 NARS1 DNAJB11 DNAJB9 ERP27 HEL-S-125m TRIB3 HEL-S-89n ERN1 ATF3 NRF2 ARE REGULATION%WIKIPATHWAYS_20260610%WP4357%HOMO SAPIENS NRF2 ARE regulation PIK3CA YES1 PRKCA HMOX1 NQO1 GCLM KEAP1 RBX1 AIMP2 GCLC MAF SLC7A11 GSK3B MAPK8 NFE2L2 CEBPB EPHB2 INSR SRC FYN PGAM5 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer JAG2 NOTCH1 TGFBR2 DLL3 DLL4 CTDSP1 CLDN6 RBBP4 TJP1 FMNL2 PIK3CD CDH2 MAP2K3 WNT3A TRAF6 EED SMAD4 MAP2K6 HEL-S-79 CLDN2 FOXQ1 EZH2 CDKL2 CLDN5 CLDN4 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 ID1 MEF2D PALS1 NRP2 MAP2K1 CLDN22 CLDN20 MAP2K2 CLDN24 CLDN23 SHC1 PROX1 CLDN11 CLDN10 LATS2 FZD7 CLDN15 TGFBR1 CLDN14 MMP15 CLDN19 FZD8 STRAP CLDN18 RAF1 CLDN17 CLDN16 TMPRSS4 NUBPL CRB3 TWIST2 SMAD2 SPARC SUZ12 FOXC2 CLDN1 ZEB2 GRB2 SNAI1 SNAI2 LRP5 MAPK12 LRP6 MAPK13 MAPK11 HRAS FZD1 NOTCH3 NOTCH4 RBPJ PIK3CA SOS1 COL4A3 MAPK8 COL4A5 PAK1 MAPK1 MAPK3 AKT3 NR2C2 MAPK14 GDF15 SOS2 GIG8 TUSC3 JUP COL4A2 COL4A1 COL4A4 COL4A6 HIF1A MMP9 MAP2K4 VTN MMP2 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 PKD1 WNT5B PIK3R1 WNT9B WNT9A WNT16 WNT8A TWIST1 WNT8B WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 WNT7A NOTCH2 TGFB1 FOXM1 WNT1 FZD2 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260610%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RARB RDH10 RDH8 RLBP1 RPE65 RDH12 ABCG8 ABCG5 RBP1 RDH5 LRAT LPL CYP2E1 RXRA NPC1L1 MAPK1 HEL-S-53e CD36 RETSAT ADH1A SDR16C5 CYP26B1 AWAT2 SCARB1 BCO1 CRABP2 HEL-S-4 CRABP1 DHRS3 SULT2B1 RXRB ALDH1A3 RXRG CYP26A1 RBP7 RBP4 RBP2 DGAT1 SULT1A1 ALDH1A2 NR1B3 RARA TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260610%WP5087%HOMO SAPIENS Pleural mesothelioma MAPK10 PLCB4 CREB1 RPS6KA5 MAPKAPK2 ITGB1 VEGFB VEGFC ITGA4 ITGA2 YY1 SELE CSF2 SETD5 SETD2 CXCL1 CXCL5 KMT2C IL10 TRAF2 SETDB1 DDIT3 EED CCL5 CCL4 ATF3 CCL2 EZH2 MCL1 KIF23 RING1 RPS6KA1 IL6 MAP3K6 MAP3K5 CXCL12 PRKAB2 PRKAB1 EIF4G1 TGFA BTC SHC1 MMP3 LATS2 MMP14 MAP3K10 ATF2 MAP3K11 RPS6 NTRK2 HEL-S-31 PRKAG1 PRKAG2 PRKAG3 PDGFA MAP4K2 EPHA2 MINK1 SPARC IGF2 PRKAA2 INS MAPK9 FRAT2 MAPK7 RASSF2 SOX17 RASSF3 MAP4K3 CDH18 RASSF4 MAP3K2 RASSF6 BTRC CER1 CSNK2A3 CSNK2A2 ITGB3 DKK1 DKK2 ITGAV DKK4 SFRP1 NTF4 SFRP5 CSNK2B IDO1 STK38L KITLG PHC1 RASSF7 BAP1 CSF3 ITGA6 LIMD1 BMI1 PRSS23 TEAD2 FGF3 TEAD3 FGF4 TEAD4 CD44 FGF6 KREMEN1 FGF7 PIGF FGF9 VGLL4 WIF1 CTNNA1 IL1B CTNNA3 CTNNA2 RYK COL4A3 NOTUM COL4A5 MAD2L1 CTBP2 WWC1 CDH9 EFNA5 CDH8 EFNA4 CDH6 FGF20 HEL-S-104 CDH4 FGF22 HMGN1 FGF21 ROR1 EGFR ROR2 FGF17 TNIK EFNA1 MAD1L1 DVL3 DSC3 EFNA3 PORCN FGF14 BAG2 EFNA2 CDH24 MOB1A FGF19 LIN28B FGF18 OGT MCU FGF10 CHD8 MDK FLT4 WDR5 SOST SENP2 LATS1 CDH10 CDH12 CDH15 CDH16 CDH19 SLC3A2 CXXC4 CTHRC1 MOBKL1A IL34 ASXL1 COL4A2 CSNK1A1L COL4A1 COL4A4 COL4A6 ANGPT4 ANGPT2 PDGFD PDGFC GSK3B WNT2B FZD10 WNT5B ITGB4 FOXO1 LAMC2 WNT16 LAMC1 RB1CC1 MLST8 WNT3 WNT4 ULK1 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A AREG LAMA5 LAMA1 LAMA4 LAMA3 FRAT1 CTBP1 PAK6 PAK4 LAMB3 LAMB2 LAMB1 VEGFD NF2 YAP1 DVL1 FZD2 CDK7 CDH17 ITGA1 TTI1 CSNK1A1 UHRF1 HEL-S-1 PRKAA1 CSF1 RBBP4 APC HMGB1 AGER PIK3CD FGF8 CDH2 MAP2K3 WNT3A CTGF AJUBA NTRK1 NGF EIF4B MAP2K6 FOSL1 MAP3K1 FGFR4 RPS6KB1 CSNK2A1 CCND1 MEF2D MYC MAP2K1 ULK2 MAP2K2 BBC3 HGF TSC2 CCND3 TSC1 FZD7 CCND2 AXIN1 NTF3 FZD8 SFRP4 RAF1 DVL2 ACTG2 CCNE1 EIF4EBP1 BARD1 JUN SUZ12 RHEB CDK4 SP1 CDK2 FGF13 BCL2 MDM2 GRB2 FGF12 ATM CYCS CDKN1A LRP5 PTEN BRCA1 RPTOR LRP6 NGFR BDNF HRAS CDH11 JAK1 FZD1 MAP4K1 AMOT NLRP3 HBEGF PIK3CA SOS1 DEPTOR MAPK8 PAK1 AKT1S1 MAPK1 PPARGC1A SLC7A5 MAPK3 FLT3 STAT1 CDKN2A RNF2 AKT3 MAPK14 WWTR1 MTOR TERT BAX KIT CSF1R FLT3LG LEF1 TCF7L2 TCF7L1 hCG_2014051 PDGFRA FLT1 RPS6KB2 ANGPT1 SRC FGF2 HIF1A MMP9 VEGFA IGF1R KDR DKFZp781B1423 MAP2K4 FGFR2 CIT RASSF1 EGF MMP2 MAP2K5 FGFR1 IGF1 INSR NFKB1 PRB1 PRB2 FGF23 CD47 FGFR3 ACTA2 TNNT1 LGALS9 ACTG1 PS1TP5BP1 TGFB1 BAK1 FOXM1 HCFC1 GABPA ACTA1 WNT1 MAX OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260610%WP3287%HOMO SAPIENS Overview of nanoparticle effects CRP HMOX1 BAX IL6 LAMA3 PIK3CD BCL2 CCND3 CXCL8 COL4A1 NFRKB PTGS2 TNF PTGS1 AKT3 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260610%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C4 SULT2B1 SULT1A1 SULT1E1 PAPSS2 SULT2A1 PAPSS1 HEL-75 SULT1C3 SULT1B1 SULT1C2 SULT6B1 SULT1A4 SULT1A2 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260610%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG12 ALG1 ALG11 DPM1 DPM2 DPM3 GCS1 DPAGT1 B4GALT1 TUSC3 GMPPB MAGT1 MGAT2 ALG8 MPDU1 SRD5A3 ALG9 DOLK ALG6 ALG2 ALG14 ALG13 ALG3 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260610%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte DGIC CEBPG HSPB7 CIDEA SMAD9 EBF3 SLC7A10 CEBPA ZIC1 PRDM16 DKFZp781O1323 HOXC9 ZNF423 HOXC8 MPZL2 CEBPB BMP7 SMAD1 PPARGC1A LEP PPARGC1B BMP4 PPARG BMP2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP75%HOMO SAPIENS Toll like receptor signaling MAPK10 MYD88 IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 CXCL9 MAPK1 CXCL8 MAPK3 IFNA21 STAT1 TNF IKBKB AKT3 TBK1 MAPK14 IKBKG CHUK IFNAR2 IRF3 MAP2K3 TRAF3 RELA TRAF6 CD14 IRF7 TLR7 IFNAR1 CCL5 CCL4 CCL3 RIPK1 MAP2K6 FADD MAP2K4 IFNB1 IKBKE MAP3K8 IL6 CXCL11 MAP2K1 MAP2K2 LBP TAB3 NFKBIB TLR4 opn NFKB1 CD40 CD80 MAP3K7IP1 JUN TICAM2 IRAK4 TICAM1 TIRAP TLR9 IL12B TLR8 IFNA5 IL12A TLR5 IFNA4 TLR3 MAPK9 IFNA7 NFKBIA IFNA6 IFNA1 IFNA2 IFNA8 MAP3K7 MAPK12 MAPK13 CASP8 MAPK11 TLR1 IRAK1 RAC1 LY96 FOS REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling MAPK10 RBCK1 SMAD6 CXCL9 CXCL8 TNF IRAK2 TBK1 IRAK3 IFNAR2 PIK3CD IRF3 MAP2K3 TRAF3 TRAF6 IRF7 TLR7 IFNAR1 SOCS1 CCL5 CCL4 CCL3 TNFAIP3 RIPK1 MAP2K6 FADD IFNB1 PTPN6 IKBKE MAP3K8 IL6 CXCL11 SQSTM1 MAP2K1 MAP2K2 MAP3K7IP1 JUN PLK1 TICAM2 BTK IRAK4 TICAM1 TIRAP TLR9 TLR8 IFNA5 TLR5 IFNA4 TLR3 MAPK9 NFKBIA IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 PIK3R5 SYK MAPK12 MAPK13 CASP8 MAPK11 TLR1 IRAK1 MBL2 RAC1 FOS MYD88 PIK3CA IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 MAPK1 RNF41 MAPK3 IFNA21 STAT1 IKBKB AKT3 TMED7 MAPK14 IKBKG CHUK RELA CD14 MAP2K4 PIK3R3 LBP PIK3R2 TAB3 OTUD5 PIK3R1 FBXW5 TLR4 CD180 opn TRAFD1 NFKB1 SIGIRR NFKB2 CYLD MLST8 CUEDC2 TREM1 CD40 SFTPD CD80 PELI1 ZMYND11 RNF31 SFTPA2 PELI3 SARM1 IL12B IL12A MAP3K7 TIFA CISH LY96 NAD METABOLISM%WIKIPATHWAYS_20260610%WP3644%HOMO SAPIENS NAD metabolism NRK SIRT4 NMNAT3 SIRT6 SIRT7 NMNAT1 NADK SIRT5 NMNAT2 SIRT2 SIRT3 NAMPT NT5E SIRT1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260610%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4EBP1 MTOR PIK3CA HEL164 MAP3K5 PIK3CD MAP2K3 MAP2K1 MAP2K2 PIK3R3 PRKAA1 PIK3R2 TSC2 PIK3R1 TSC1 MAPK1 MAPK3 MAP3K11 RAF1 EIF4E MAP2K6 ADIPOGENESIS%WIKIPATHWAYS_20260610%WP236%HOMO SAPIENS Adipogenesis NR3C1 CREB1 RETN KLF6 TNF PTGIS IL6ST GATA3 SCD IRS1 EGR2 DDIT3 SOCS3 SOCS1 TRIB3 IRS4 STAT2 RB1 IL6 MEF2D LPL PCK1 MEF2C SFRP4 CYP26B1 GADD45B GADD45A CYP26A1 FOXC2 RXRG SP1 AHR INS CNTFR MBNL1 CDKN1A NR1H3 FZD1 OSM LIF BMP1 MEF2B NCOA1 FRZB NAMPT HNF1A PRLR RXRA PPARGC1A NCOR2 NCOR1 STAT1 GH1 NR1C2 STAT3 HMGA1 WWTR1 LIPE CEBPA GDF10 RBL2 STAT5B HIF1A UCP1 RORA GATA4 IGF1 WNT5B FOXO1 CEBPB BMP3 CEBPD TWIST1 SLC2A4 LEP PPARG WNT10B LPIN1 PCK2 GATA2 BSCL2 LPIN2 LPIN3 CISD1 GTF3A ADFP CFD ZMPSTE24 NDN NR2F1 TGFB1 ID3 CELF1 KLF15 RBL1 LMNA PLIN1 ASIP SPOCK1 E2F4 KLF7 KLF5 BMP4 PNPLA3 NR1C1 MIXL1 BMP2 DVL1 WNT1 RARA OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260610%WP5093%HOMO SAPIENS Opioid receptor pathways FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5102%HOMO SAPIENS Familial partial lipodystrophy MGLL PIK3CA CIDEA KLF2 LPL HEL-S-104 PPARG GATA2 GATA3 LIPE CEBPA PRRX1 PNPLA2 INS LMNB2 ZMPSTE24 MAPK9 STAT5B LMNA PLIN1 KLF5 NR1C1 FNTA BANF1 ICMT CIDEC KLF9 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260610%WP47%HOMO SAPIENS Hedgehog signaling DHH SIN3A SUFU ADRBK1 PTCH2 IHH SAP18 GLI3 KIF7 SHH PTCH1 SMO AGE RAGE PATHWAY%WIKIPATHWAYS_20260610%WP2324%HOMO SAPIENS AGE RAGE pathway MYD88 CDC42 MSR1 ARHA MAPK8 MAPK1 MAPK3 EGFR STAT1 STAT3 IKBKB MAPK14 CHUK AGER IRS1 RELA STAT5B SRC HIF1A MMP9 PRKCB NCF1 PRKCA DDOST EZR HEL70 PRKCZ MMP2 MAP2K1 INHBB MMP7 HEL-S-44 SHC1 FOXO4 FOXO1 MMP14 INSR NFKB1 ATF2 RAF1 ALPL SMAD2 ROCK1 JUN NOS2 IRAK4 TIRAP SP1 INS MAPK9 NFKBIA CYCS CASP9 CASP8 CASP3 RAC1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260610%WP474%HOMO SAPIENS Endochondral ossification PTH1R BMPR1A IHH PLAT CDKN1C ADAMTS4 ADAMTS5 MGP NKX3-2 FRZB SOX6 SOX5 CAB39 PTHLH CST5 KIF3A HMGCS1 STAT1 GH1 PTCH1 FGF18 GHR ACAN COL10A1 STAT5B SOX9 FGF2 RUNX2 MMP9 IGF1R VEGFA TIMP3 DDR2 FGFR1 IGF1 PTH CHST11 BMP6 opn RUNX3 MEF2C THRA ALPL ENPP1 COL2A1 FGFR3 SCIN GLI3 IGF2 TGFB1 CALM1 BMP7 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260610%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNB1 STAT2 IKBKE MAVS RIGI IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 STAT1 TBK1 IFNAR2 TICAM1 ACE2 IRF3 IFNA5 IFNA4 IFIH1 TRAF3 TLR3 IFNA7 TYK2 IFNA6 IFNA1 IFNA2 IFNA8 IFNAR1 IRF9 JAK1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260610%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination FGFR2 ROCK1 FRAT1 FGF9 GADD45G GSK3B ARHA FOXL2 SRY SOX9 MAPK1 AXIN1 MAPK11 WNT4 MAP3K1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260610%WP4842%HOMO SAPIENS Mammalian disorder of sexual development DHH FGFR2 PBX1 FGF9 GATA4 FST FOXL2 SOX9 SRY EMX2 RBFOX2 DMRT1 CBX2 AMH NR5A1 MAPK11 RSPO1 WT1 WNT4 SOX8 INSL3 AMHR2 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260610%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling CSF3 SP7 EGR1 RPS6KA5 ITGB1 IL1B MAPK8 SMAD6 MAPK1 CSF2 CXCL8 PPARGC1A MAPK3 TJP1 CXCL1 CXCL2 SLPI TNF MST1R CXCL5 KLK15 NR0B2 ACACA MAPK14 MTOR IL10 RPS6KA4 CDH2 RELA IBSP PDGFRA SMAD1 COL4A1 SOCS3 FLT1 SOCS1 SRC CCL2 MMP9 IGF1R VEGFA KDR RPS6KB1 PRKCB PLCG1 IFNB1 CLDN5 PDPK1 RPS6KA1 HEL-S-133P SMAD9 IL6 CRKL DKFZp781O1323 DUSP4 MAP2K1 GSK3B FGFR1 MAP2K2 PCNA SHC1 CPT1A PIK3R1 NFKB1 RPS6 RAF1 WNT10B SMAD2 SIX1 JUN ACTA2 HK2 PRKAA2 CLDN1 ZEB2 MAPK9 GRB2 TGFB1 SNAI2 PTEN HEL-S-102 FZD1 HEL113 BGLAP FOS MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260610%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors SDC2 ITGA1 THBS1 LAMA4 THBS2 COL1A2 LAMB2 COL5A3 COL6A1 COL5A2 XB LAMC1 COL4A2 COL4A1 ITGB6 COL3A1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260610%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders COQ2 FLAD1 SLC52A2 SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260610%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology SOS1 SYNE2 HEL-S-15 MAP2K1 MAP2K2 ARHA NRAS MAPK1 MAPK3 TMEM43 SMAD2 HEL-S-61 WWTR1 ADCY3 SOS2 ADCY1 SYNE4 ADCY8 SYNE3 LBR GRB2 ADCY6 CTGF EMD TGFB1 SUN1 ADCY5 LEMD3 HEL-S-7a YY1AP1 ADCY9 PLEC SMAD4 HRAS BANF1 SYNE1 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260610%WP5241%HOMO SAPIENS Mitochondrial beta oxidation HSD17B10 ACADSB ECHS1 ACADL EHHADH ACSL3 DECR1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis AKR1C1 HSD11B1 HSD11B2 AKR1C2 SRD5A2 AKR1C4 CYP11B2 AKR1D1 CYP3A4 CYP21A2 TNF ALPHA SIGNALING%WIKIPATHWAYS_20260610%WP231%HOMO SAPIENS TNF alpha signaling SOS1 TXN NFKBIE MAPK8 MAPK1 TRADD MAPK3 BAD TRAF1 TNF IKBKB TBK1 IKBKG CHUK MADD BAX TRAF2 PIG59 MAP2K3 TANK CREBBP OTUD7B TNFAIP3 PYGL SMPD2 RIPK1 MAP2K6 PSMD2 FADD MAP3K1 FBXW11 BCL2L1 CYBA MAP2K4 KSR2 REL SKP1 PTPRCAP NSMAF DIABLO RFFL CSNK2A1 MAP3K8 PRKCZ MAP3K5 TAB3 NFKBIB RIPK3 KSR1 NRAS NFKB1 NFKB2 MAP3K14 APAF1 RAF1 TNFRSF1B MAP3K7IP1 BIRC2 BIRC3 PPP2CA CDC37 MAP4K2 JUN PLK1 MAPK9 NFKBIA GRB2 MAP3K7 BTRC CASP9 CASP8 CASP3 HRAS RAC1 TNFRSF1A COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260610%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway IL7 CSF3 IL2RA TMPRSS2 IL6 IL10 ACE2 IL2 IL1B CXCL8 CCL3 CCL2 TNF NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260610%WP4747%HOMO SAPIENS Netrin UNC5B signaling PIK3CA NTN1 PRKCA RLF NTN3 INPP5D PLEKHH1 ARHGEF12 AGAP2 UNC5B CIP2A MAP2K1 DCSTAMP COL1A1 MYF5 MAP2K2 VCAM1 ARHA ITGB4 MAPK1 SELE PTK2B MAPK3 RAF1 ALPL PPP2R1B TNF RGMA PTPN11 MAPK14 ROBO4 JUN IL10 CTGF PTPA YAP1 SRC CASP3 FYN IL1A CCL2 KDR RAC1 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260610%WP4297%HOMO SAPIENS Thiamine metabolic pathways PDHA1 DKFZp667O1614 SLC19A2 HEL107 OGDH BCKDK SLC19A3 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260610%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCG1 PIP4K2A OCRL PIK3CA PLCB3 PIK3R4 PIP5K1C PLCB4 INPP5D PLCG2 PLCB1 PLCB2 PLCD4 MTMR1 MTMR10 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 MTMR6 MTM1 PIP4P2 PIP4P1 PIP5K1A PLCE1 PIP4K2B SBF1 SBF2 SACM1L PIKFYVE PLCH1 PLCH2 PLCD3 PIK3CD PTEN PIK3C2G PIK3C2B PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260610%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IFNB1 MAVS RNASEH2C RIGI RNASEL IRF3 RNASEH2B RNASEH2A IFIH1 TREX1 RNASET2 CGAS MITA OAS1 ADAR CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SQLE HMGCS1 SC5D MSMO1 HMGCR MVD FDFT1 FDPS MVK PMVK DHCR7 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260610%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F2 CYP4A22 CYP2C18 CYP4A11 PPARG NR1C1 CYP4F12 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260610%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling EIF4EBP1 MAPK14 MTOR PRKCA RHEB FSHR CREB1 TSC2 FOXO1 MAPK1 SGK1 RPS6KB2 MAPK3 FSHB SRC RPS6 H3-4 RAF1 CGA APPL1 RPS6KB1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260610%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GCK HK2 UXS1 HK3 UGDH GFPT1 PGM3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260610%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 CMA1 CTSG REN TGFB1 AGTR1 AGTR2 CYP11B2 KNG1 BDKRB2 ATP6AP2 BDKRB1 NR3C2 MAS1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260610%WP4147%HOMO SAPIENS PTF1A related regulatory pathway KAT2B HES1 PROX1 NKX6-1 RBPJ PTF1A NOTCH1 FGF10 PDX1 RBPJL INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260610%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 MX1 IRF-1 IFI35 IFIT1 PSMB8 IFIT3 IFNAR2 TYK2 PIAS1 OAS1 IFNAR1 IFITM1 IRF9 SOCS1 IFNGR1 IFNGR2 STAT1 JAK1 IFNG VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260610%WP4271%HOMO SAPIENS Vitamin B12 disorders CBLIF MTR CUBN MTRR AMN MMAA TCN2 TCN1 MMACHC MMADHC CD320 VITAMIN D METABOLISM%WIKIPATHWAYS_20260610%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27A1 PTH CYP2R1 RXRA GC NR1i1 RXRB CYP27B1 CYP24A1 DHCR7 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260610%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease COX5A COX7A1 COX3 VCAM1 NDUFA9 PRKAA1 NDUFA5 CXCL8 ERN1 TNF IL6R BCL2L11 IRS1 TRAF2 PIK3CD XBP1 DDIT3 SOCS3 CCL2 NDUFB10 ITCH IL6 SDHB MAP3K5 PRKAB2 NR1H4 PRKAB1 NDUFA10 BBC3 MLXIPL MAP3K11 GSK3A PRKAG1 PRKAG2 LEPR PRKAG3 ATF4 JUN CYB PRKAA2 INS EIF2S1 NDUFS8 UQCRC1 MAPK9 UQCRFS1 NDUFS3 COXFA4 UQCRC2 CYCS SDHA UQCRB UQCR11 UQCR10 UQCRH NR1H3 CYC1 CASP8 CASP3 UQCRQ RAC1 PIK3CA CDC42 IL1B SDHC SDHD MAPK8 RXRA COXFA4L2 NDUFC2-KCTD14 COX6B2 NDUFB11 ADIPOR1 COX7B2 COX4I2 MLX COX8C MLXIP UQCRHL IKBKB AKT3 NDUFA13 NDUFA11 NDUFA12 BAX COX6A2 NDUFC2 CEBPA NDUFC1 COX7A2L NDUFS6 NDUFS5 NDUFS4 RELA NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 COX7A2 NDUFV3 NDUFV2 GSK3B PIK3R3 PIK3R2 CYP2E1 PIK3R1 NDUFA7 NDUFA6 ZNF183 INSR NFKB1 NDUFA3 NDUFA2 LEP NDUFAB1 COX7B COX6A1 ADIPOR2 COX2 COX1 COX7C TGFB1 COX8A BAK1 COX6B1 NR1C1 IL1A TNFSF6 PKLR TNFRSF1A DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260610%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control AIFM1 HSPD1 PARK2 OPA1 HTRA2 MICOS13 MIPEP UFD1L XPNPEP3 UBXN1 CLPB OPA3 GDAP1L1 MFN1 SACS MFN2 PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP LONP1 TMEM126A YME1L1 MICU1 VCP SPG7 TRAK1 MFF TIMM50 PITRM1 MSTO1 MARCHF5 DNAJC19 TIMM8A TIMMDC1 TXNRD2 AGK USP9X GFER COQ5 MCL1 COQ3 PINK1 NPLOC4 PLEK STAT2 SFXN4 RTN4IP1 PYCR2 TXN2 C1QBP ENDOMETRIAL CANCER%WIKIPATHWAYS_20260610%WP4155%HOMO SAPIENS Endometrial cancer PIK3CA SOS1 AXIN2 HEL-S-28 CTNNA1 CTNNA3 CTNNA2 MAPK1 MAPK3 EGFR BAD APC ARAF AKT3 BAX SOS2 PIK3CD LEF1 TCF7L2 TCF7L1 FGF2 FGFR2 PDPK1 APC2 CCND1 ERBB2 EGF MYC MAP2K1 GSK3B FGFR1 MAP2K2 PIK3R3 PIK3R2 PIK3R1 NRAS AXIN1 FOXO3A RAF1 DDB2 FGFR3 POLK GADD45B GADD45A GADD45G GRB2 BAK1 CDKN1A PTEN CASP9 HRAS FOS FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260610%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR5 FLT3 STAT3 CCR6 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260610%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 ACLY PC HEL60 HEL-S-26 DLAT SUCLG2 SDHA OGDH PCK1 DLD CS FH HEL-S-32 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2877%HOMO SAPIENS Vitamin D receptor pathway TNFRSF11B CLMN TRPV5 CREG2 SPRR1B CDKN2D LRRC25 S100G KRTAP10-2 SALL4 KRTAP10-4 CDX2 KRTAP10-7 MX2 KRTAP10-9 ADAMTS5 CBS KRT13 G0S2 MYO9B ATP2B1 PTHLH DEFB132 KRT16 CD9 CTLA4 THBD JUNB BCL6 TNFAIP3 CLDN2 NR1i1 CCND1 ID1 DUSP10 MYC CCNE1 HLA-DQA2 HLA-DQA1 GADD45A CYP7A1 CDK2 HLA-DRB1 CDKN1A LRP5 CDKN1B EPHB4 SFRP1 S100A9 DNER IRF4 KLF4 ABCB1 HNF1A S100A6 CYP2C9 IRF8 RXRA CYP2B6 HSD17B2 EFNA5 MED9 SULT2A1 ITGAM CDKN2B CDKN2A NR1C2 CLEC16A CEBPA ADRB2 STEAP4 CD14 TRAK1 ALOX5 HIF1A SULT1C2 TIMP3 NFATC2 PRKCQ CYP1A1 LPGAT1 CCNC GXYLT2 TNLG2B SLC8A1 CYP3A4 STS KRT71 CDKN2C SLC34A2 LCE1F LCE1D LCE2B KL CDC34 NINJ1 PTH S100A4 BMP6 S100A8 FOXO1 COL13A1 opn CDKAL1 KLK6 ADGRE5 CRACR2A CYP27B1 CRACR2B SLC2A4 DND1 CYP24A1 BTLA TREM1 KRTAP4-1 CD40 SLC37A2 KRTAP12-2 KRTAP8-1 FGF23 TRPV6 CYP2S1 PNOC TPM1 ID4 CST6 ALPI CLPTM1L IL1RL1 MXD1 IGFBP5 ALPG ZNF257 CD200 ORM1 HILPDA IL25 ADRA1B ORM2 IL12A CASP14 LGALS9 CASP5 DACT2 TGFB1 SOSTDC1 KRTAP5-1 S100A2 CA9 IGFBP1 ABCD1 CAMP KRTAP5-4 KRT34 CEACAM1 KRT38 DEFB4B PTGER4 KNG1 COLEC11 SATB1 BDKRB1 HEL57 SEMA3B ASAP2 BGLAP TNFSF11 CST1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260610%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins CTH RPL30 SELENOF NFE2L2 SELENOK SELENOI SELENOH NFKB1 SEPHS1 SEPHS2 PSTK EEFSEC FABP1 GPX2 GPX1 CREM POU2F1 GPX3 GPX6 DIO1 TRNAU1AP SELENOO SEPSECS JUN SELENON SARS1 SELENOM SARS2 SELENOP SELENOW SP1 SELENOV SELENOT MSRB1 SELS RELA SP3 HEL-S-134P GPX4 TXNRD2 FOS MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260610%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CLDN4 ITGA6 TERT ERBB4 CCND1 MYC ZEB2 ITGB1 NRG3 TGFB1 SFRP1 ALPL TNF 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260610%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome NFATC2 CD81 LAT IFITM1 INSR SH2B1 TRAF1 CD82 RABEP2 CD19 TRAF2 PRMT1 ATP2A1 IL4 GRB2 PLN SLN NFATC2IP RAB5A RAB4A CR2 HEL-S-62p TUFM ATXN2L SPNS1 SDCCAG8 MPL KDR VAV2 CCL18 SIGNALING%WIKIPATHWAYS_20260610%WP5097%HOMO SAPIENS CCL18 signaling CCR8 PTK2B MMP2 AK4 CDH2 ZEB2 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260610%WP3527%HOMO SAPIENS Pre implantation embryo IRF4 EGR1 CDX2 TEAD4 ELAVL1 KLF4 SOX8 MACROH2A2 HMGA1 TFAP2B GATA3 BATF3 TCF7L1 DDIT3 NANOGNB AQP9 AQP3 DNMT3L KHSRP FOSB FOXQ1 SIX3 MYBL1 SOX11 ZAR1 ARGFX DPPA3 ZFP42 PADI6 BARX2 ZFP36L2 LEUTX NKX2-1 ZFP36 MTA3 SOX2 IRX5 TPRX1 HNRNPAB TBX3 MOS DPRX ZSCAN4 DLX2 GATA2 MXD1 SMARCA4 E2F5 PBX1 ESRRA ATP1A1 FOXD1 POU5F1 NR3C2 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260610%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260610%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RC IL17RA MITOPHAGY%WIKIPATHWAYS_20260610%WP5636%HOMO SAPIENS Mitophagy MAPK10 RAB7A BCL2L13 PARK2 SMURF1 OPA1 MAPK8 BNIP3 TBK1 MFN1 MFN2 PHB2 TRAF2 VCP MARCHF5 SRC HIF1A PGAM5 BCL2L1 PINK1 TOMM70 CSNK2A1 SQSTM1 ATG9A CITED2 TOMM20 FUNDC1 ARIH1 USP30 FOXO3A ATG9B TFEB MUL1 ULK1 RAB7B OPTN USP15 RAB5B NLRX1 RAB5C TOMM40 BECN2 AMBRA1 ATF4 RHOT2 JUN RHOT1 SAMM50 TBC1D17 TBC1D15 FIS1 MTX1 SP1 AMFR HUWE1 CCZ1 EIF2S1 MAPK9 NBR1 TOMM7 RAB5A BNIP3L CSNK2A3 CSNK2A2 CALCOCO2 MAP1LC3A SIAH1 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260610%WP615%HOMO SAPIENS Senescence and autophagy in cancer IRF-1 BMI1 SERPINB2 PLAT CD44 IL24 IL1B DKFZp762B153 ATG14 AKT1S1 MAPK1 CXCL8 CXCL1 KMT2A CDKN2A IL6ST HMGA1 MAPK14 MTOR IL6R MAP2K3 IRF7 COL10A1 IL3 SRC SMAD4 CCL3 IGF1R INHBA CXCL14 VTN IFNB1 ATG3 THBS1 RB1 ATG10 IL6 ATG12 SQSTM1 DKFZp686F0183 MAP2K1 ATG16L1 GSK3B COL1A1 PCNA IGF1 CEBPB CDC25B MMP14 RB1CC1 GABARAPL2 MLST8 GABARAPL1 TNLG1B RAF1 ULK1 COL3A1 AMBRA1 JUN GABARAP IGFBP5 SPARC RNASEL INS BCL2 MDM2 ING1 TGFB1 LAMP2 SLC39A2 CDKN1A SLC39A1 CDKN1B SLC39A3 PTEN SH3GLB1 IFI16 CREG1 IGFBP7 UVRAG RSL1D1 HRAS IL1A BMP2 MAP1LC3A IFNG MAP1LC3C TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260610%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TBP H4C9 MED23 TAF13 TAF8 MED27 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome DRD2 HES1 EMC10 POLR2A FGF8 H4C9 CLDN5 CLDN3 CRKL GLUD1 CDC45 RAF1 CYP26B1 CLTCL1 PLK1 SREBF2 CYP26A1 FOXC2 CLDN1 BCL2 GSC2 HDAC3 HIRA HIRIP3 TSKS ZDHHC8 RCC1 PITX2 C22orf39 THAP7 ASF1A RTL10 MED15 NPRL2 TRMT2A ESS2 CDC42 NKX2-5 PRODH HEL25 KLHL22 GP5 GP9 PARK2 LRRC74B SEPT8 MRPL40 DGCR6L DGCR8 TNPO1 SCARF2 DGCR2 GP1BB PAX3 C16orf35 GP1BA NCOR1 EGFR SEPT5 SLC7A4 GBX2 CYP26C1 GNB1L UFD1L DEPDC5 CCDC188 FOXC1 hCG_1641087 ARVCF DROSHA FGF10 TBX1 RANBP1 SERPIND1 ZNF74 HAND2 RAN CDH15 HEL-S-80p SHOC2 TXNRD2 FOXA2 FGFR2 RBX1 FGFR1 RTN4R SNAP29 SLC2A4 VWF ACTA2 RTN4 SHH RELN PAK4 P2RX6 ALDH1A2 SLC25A1 RORC EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260610%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 EIF5A XPO4 MTHFR DEFICIENCY%WIKIPATHWAYS_20260610%WP4288%HOMO SAPIENS MTHFR deficiency PEMT EHMT1 MARS1 CHKA HEL-S-61p CHDH CHPT1 CYCS ASMT ALDH7A1 GRIN1 CASP9 CASP3 DNMT3B CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2406%HOMO SAPIENS Cardiac progenitor differentiation BMP1 NOTCH1 SIRPA ZFP42 NODAL NKX2-5 MYL2 SOX2 GSK3B GATA4 NOG IGF1 CXCR4 MEF2C LIN28A TNNI3 ROR2 NRG1 MAPK14 LIN28B KIT MESP2 IGF2 MYLK3 MYH6 INS WNT3A TGFB1 MESP1 SOX17 THY1 TBXT SOX1 TBX20 SCN5A PDGFRA IRX4 TBX5 ISL1 DKK1 BMP4 FGF2 MIXL1 POU5F1 INHBA FOXA2 KDR NCAM1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260610%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance CDKN1A ABCB1 HIF1A BCL2L1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260610%WP5145%HOMO SAPIENS COVID 19 structural coverage map UBB UBC TOMM70 MACROD1 HEL97 MACROD2 CMTR1 PAIP1 ACE2 PALS1 UPF2 SLC6A19 NRP1 AQR IGHMBP2 ISG15 MACROH2A2 PARP14 GDAP2 MAP3K7IP1 NLRP12 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260610%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways CAMK2A MYL4 PLCB3 HEL-S-93 PRKAR1B LPAR1 HEL2 PRKAR1A MYL2 CREB1 GNAS YWHAQ HEL-S-1 YWHAG CAMK2D DKFZp686L0365 GNGT1 PDE4B PDE4D PRKD1 CACNB3 GNG3 GNG5 GNG4 GNG7 GNG8 ATF3 GNG12 GNG11 GNG13 DGKZ GNB2 GNB1 GNB5 ATF1 IL6 ATF2 CALCA PRKCE ATF4 JUN SFN SP1 HEL-S-21 CALM1 FOS RGS16 IL1B RYR1 RYR2 RYR3 GNB4 MYLK2 GJA1 ADCY3 ADCY1 ADCY8 CREB3 ADCY6 ADCY5 ACKR3 ADCY9 ATF6B RAMP1 GNG2 PRKCB PLCG1 PRKCH PRKCA PRKCQ PRKCZ OXTR CRCP SLC8A1 RXFP2 PLCG2 RGS4 RGS5 CRH RGS2 RGS1 RGS6 IGFBP4 MAFF ATF5 ETS2 HEL-S-14 ITPR2 CNN2 GRK5 GRK4 NFKB1 CALD1 IGFBP6 PKIB PKIA RLN1 PKIG ADM OXT RGS18 RGS17 RAMP2 RAMP3 RGS20 CAMK2G ACTA2 CORIN IGFBP5 GUCA2B GUCA2A RGS10 RGS11 ACKR5 ACTG1 GNB3 PS1TP5BP1 GABPB1 IGFBP1 IGFBP2 GABPA ACTA1 ATP2A2 RGS14 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260610%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions TEAD2 TEAD3 TEAD4 YWHAQ ARHA LPL FOXO4 CCR7 FOXO1 LATS2 FOXP3 FOXO3A RAP1A MAPK14 MOB1A WWTR1 CD19 FOXO6 LATS1 FYB1 KNSTRN RAB13 FERMT3 YAP1 RAC1 STK38L COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260610%WP545%HOMO SAPIENS Complement activation C1QB CFD C4A C1S CFP C8A C6 C1QA C8G HEL-S-62p C7 C9 MASP2 MASP1 CFB CD55 C1QC C4B_2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260610%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity C4BPA C4BPB CLU ITGAX MFGE8 C3AR1 DLGAP5 CR1 ATP11C ATP11A PLSCR1 PLSCR3 PLSCR4 CD46 LLGL2 CRB2 MERTK CX3CL1 COLEC12 CRB1 AXL COLEC10 CFH C1QA C5AR2 CFI C5AR1 HTRA2 PARD6G ATP10A ITGAM PARD3 PARD6A CD59 DEDD MARK1 ATP8B3 ATP8B2 MBP BAX PARD6B CR2 HEL-S-62p VTN PRKCI DIABLO PRKCZ ATP8B1 PALS1 C4A APAF1 C4B_2 TYRO3 C1QB CAP1 CX3CR1 CFD C1S TGFB1 CASP10 CFP BAK1 CYCS C8A C6 C8G C7 C9 MASP2 ITGB3 CASP9 MASP1 CASP8 CFB CASP3 ITGAV CD55 COLEC11 C1QC FCN1 MBL2 TNFSF6 FCN2 SCRIB IFNG PATJ SERPING1 FCN3 PROS1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260610%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNA HEL-S-62p CFB CFD FNTA LMNB2 ICMT RCE1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260610%WP5485%HOMO SAPIENS Post COVID neuroinflammation CCL11 TMPRSS2 IL6 IL10 HMGB1 FURIN ACE2 TLR8 IL12A TLR3 IL2 IL4 IL1B IFNA2 TLR7 TLR4 GFAP MAPK1 CXCL8 IL18 IL1A IFNG TNF 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome CDKN1C OGDH BRD4 MAPK3 USF1 FBN1 UBE2L6 CHTF18 ACACB ABHD11 ACACA HMGA1 BCL7B NUP62 ATP5G1 BUD23 GTF2I HEL-S-271 VPS9D1 UBE2E3 VPS37C VPS37D ATPAF2 VPS37A VPS37B BAZ1B HEL-S-162eP LAT2 EIF2A CLIP2 METTL27 FKBP6 UBE2E1 VPS28 ATPAF1 TRIM50 UBIAD1 HDAC2 DDX21 FBLN2 FBLN5 LIMK1 MVB12A EIF4H ATP8 CLASP1 CLASP2 SMARCA5 TMEM270 ATP6 DEK ATP5MC2 TBL2 MYO1C CLDN5 MYBBP1A RFC2 CLDN4 HSPA2 GTF2IRD1 CLDN3 ATP5MC3 RB1 HEL-S-123m SQSTM1 MYC HEL-S-15 HOXC8 H2AX PCNA MLXIPL ATP5PB ATP5F1D ULK1 ATP5F1E NRG1 SNAP25 ATP5PO FZD9 TSG101 ATF4 BTK GRIP1 CLDN1 GRB2 VAMP2 STX1A HDAC3 CLTC DLD PRKG1 PKLR GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260610%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM3 GRM2 GABBR2 GABBR1 CASR GPRC5A GRM6 GRM8 GPRC5D GPRC5C NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome ATR RNF168 RNF8 CBX3 MDC1 H2AX NIPBL ATM FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2879%HOMO SAPIENS Farnesoid X receptor pathway UGT2B4 FGF19 ABCB4 CYP3A4 BAAT CYP7A1 CYP8B1 NR1H4 SLCO2B1 ABCB11 IP6K3 SLC27A5 RXRA PPARGC1A SULT2A1 FKBP5 NR0B2 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260610%WP15%HOMO SAPIENS Selenium micronutrient network PLAT HEL-S-2a TXN CBS IL1B SELENOF SELENOK SELENOI SELENOH SEPHS2 GPX2 GPX1 MPO TNF GPX3 GPX6 DIO1 CRP SELENOO FLAD1 SCARB1 SELENON ALOX15B SELENOM SELENOP APOB SELENOW SELENOV LDLR SELENOT MSRB1 SELS RELA ALOX5 HEL-75 TXNRD2 ALOX5AP CCL2 CTH MTR IL6 SERPINA3 HEL-S-44 HEL-S-97n KYNU FGA HEL-S-302 KMO F7 INSR NFKB1 SAA4 NFKB2 PLG PRDX3 PRDX5 HEL-S-78p ALB SAA1 SAA2 HBB XDH HBA2 ABCA1 INS GPX4 F2 IFNG PTGS2 PTGS1 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2874%HOMO SAPIENS Liver X receptor pathway RXRA CYP2B6 SCD FASN NR1H3 CYP3A4 ABCG8 CYP7A1 ABCG5 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260610%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA NR1i1 RARA EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260610%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 IL18 SIGNALING%WIKIPATHWAYS_20260610%WP4754%HOMO SAPIENS IL18 signaling PRKCB GRIN2B MYD88 NCF1 IL18RAP NCF2 IRF-1 PRKCA ELAVL1 CSN2 GSK3B NFATC4 PRKAA1 PIK3R1 CEBPB MAPK1 NFKB1 MAPK3 GATA1 TNF IKBKB SLC12A3 ACACB IMP3 CHUK BAX TICAM2 SP1 IL37 RELA MAPK9 NFKBIA TRAF6 CYCS MAP3K7 LCK PTEN HEL-S-102 IL18 CASP8 CASP3 IL18R1 IRAK1 TNFSF6 TNFRSF1A RPS6KB1 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260610%WP2795%HOMO SAPIENS Cardiac hypertrophic response HDAC5 MAP2K4 CDK7 FGFR2 NFATC2 IKBKE PDPK1 PRKCA PPP3CA EGF MAP2K5 MAP2K1 GSK3B MAP2K2 MAPK8 IGF1 MAPK1 NFKB1 TGFBR1 CAMK2D MAPK3 MAP3K14 RAF1 NRG1 TNF IKBKB GUCA1A MAPK14 IKBKG MTOR CHUK PRKD1 MAP2K3 MAPK7 TGFB1 CALM1 MAP3K7 CDK9 NPPA PRKG1 FGF2 HDAC7 MAP2K6 MAP4K1 MAP3K1 RAC1 PLA2G2A TNFRSF1A GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260610%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway GPAM PIK3CA CDIPT LPIN1 MOGAT3 PIP5K1A PGS1 PTDSS1 GNPAT GPAT4 HMFN0839 PTPMT1 GPD1 PEMT GPAT2 LPIN2 CEPT1 CHKB PCYT2 PIK3CD IPMK CRLS1 PI4K2A CDS2 CHPT1 PLA2G2A DNA MISMATCH REPAIR%WIKIPATHWAYS_20260610%WP531%HOMO SAPIENS DNA mismatch repair LIG1 RFC2 POLD2 POLE RFC3 RFC4 PCNA PMS2 POLE4 MSH6 MSH2 RPA1 RFC1 POLE2 RPA3 POLE3 POLD3 POLD4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260610%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCG1 PIP4K2A OCRL PIK3CA PLCB3 PIP5K1C PLCB4 INPP5D PLCG2 PLCB1 PLCB2 PLCD4 MTMR1 MTMR2 MTMR8 STM7 MTMR6 MTM1 PIP4P2 PIP4P1 PIP5K1A PLCE1 PIP4K2B SACM1L PIKFYVE PLCD3 PIK3CD IPMK PI4K2A PI4K2B INPP5E TPTE2 FIG4 INPP4A PTEN PI4KB PIK3C2G PIK3C2B INPP4B LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 EPHX2 ALOX5 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260610%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR PIK3CA EPHB2 GRK1 FPR2 CMKLR1 PIK3CD LTB4R DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NPC2 NEU4 GLA SCARB2 HEL-S-111 HEXA NEU2 NEU3 GLB1 LIPA GM2A PSAP NPC1 NEU1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260610%WP4814%HOMO SAPIENS Somatic sex determination DHH FGF9 GATA4 FOXL2 SRY SOX9 DMRT1 AMH NR5A1 RSPO1 WT1 WNT4 SOX8 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260610%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum SLX4 GTF2H2C_2 H2AC6 LIG1 CDK7 RFC2 SLX4IP GTF2H2 CHD1L POLE GTF2H3 UVSSA GTF2H4 RAD18 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 ERCC2 MNAT1 PCNA HMGN1 RPA1 XAB2 RFC1 RPA3 DDB2 POLD3 POLD4 POLK POLD2 CUL4B XPA GPS1 H4C9 H3F3B POLE4 BRCA1 HIST1H4L POLE2 POLE3 CCNH CETN2 XPC TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260610%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H4C9 H2BC12 HIRA HIST1H4L CHAF1B CHAF1A RBBP4 SMIM40 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260610%WP4925%HOMO SAPIENS Unfolded protein response CASP2 ATF4 PMAIP1 MBTPS2 BCL2L11 RTCB TNFRSF10B TXNIP EIF2S1 BCL2 PPP1R15A IL1B XBP1 BBC3 NFE2L2 DDIT3 HEL-S-89n ERN1 MBTPS1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260610%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11A MFN2 SBF2 RAB7A NEFL RAB3B EGR2 LRSAM1 RAB4B HSPB8 LITAF RAB11B FGD4 RAB4A FIG4 SH3TC2 RAB25 MTMR2 MPZ HEL-S-102 PMP22 KIF1B RABAC1 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260610%WP2857%HOMO SAPIENS Mesodermal commitment pathway RARB BMPR1A AXIN2 PRKAR1A NOG SMAD6 TRIM28 SETD2 RPL38 ATP8B2 ACACA GATA3 CUL4B CRTC1 HES7 FGF8 WNT3A TBX6 PIAS1 SMAD4 NLK AEBP2 INHBA DNMT3B FOXA1 CCND1 TBX3 SESN1 AXIN1 FZD8 CCDC6 PPP2CA SMAD2 PLCH1 FOXC2 SNAI1 SOX17 ACVR1 DKK1 C1QBP PITX2 GDF3 HTT NODAL TEAD2 KLF4 CTBP2 SOX21 CEP250 WDHD1 FOXH1 ARID5B EMSY TCF4 ADAM19 TWSG1 WDFY2 BCORL1 FOXC1 TOX GATA6 MBTD1 EPB41L5 TBX1 UBR5 PBX3 HMGA2 ZFHX4 NABP2 LATS1 TRIM71 EXT1 BCAR2 LEF1 SCHIP1 EXT2 PHF6 CSRP2 C9orf72 ZIC2 ZIC3 TRIM5 HNF4A TCF7L1 JARID2 SMAD1 LEFTY1 SLC2A12 MSGN1 TET1 PARP8 TOX3 ARL4A HAND1 AHDC1 FOXA2 WDCP LEFTY2 ZNF462 ELP4 ZIC5 SOX2 FGFR1 NFE2L2 AMH WNT3 VAV3 BHLHB2 FZD5 FZD4 BMPR2 PBX1 RGS10 ACVR2B ACVR2A BMP7 MEIS1 YAP1 NR1B3 KLF5 BMP4 MIXL1 POU5F1 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260610%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition PTTG1 MAD2L1 CDC20 CENPE STAG1 BUB1B SMC3 APC ESPL1 SMC1A MAD1L1 RAD21 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CREB1 MRE11A RAD50 BAX CCNG1 RB1 CCND1 CHEK2 MYC CHEK1 H2AX HUS1B BBC3 TP53AIP1 PIDD1 CCND3 CCND2 SESN1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 PRKDC CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP CDC2 GADD45B GADD45A CDK4 TNFRSF10B PML GADD45G CDK2 RAD52 CDK6 MDM2 RAD51 CDK5 ATM CYCS RAD17 ATR CDKN1A RAD1 CDKN1B RAD9A BRCA1 CASP9 CASP8 CASP3 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260610%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium NOTCH1 ERBB4 LRP8 APP DAB1 CXCL12 MAP1B ID1 PLXND1 MYC AGRN PSEN1 NEUROG3 SOX2 FAIM GSK3B RTN4R HES1 NDEL1 ASCL1 MEF2C NTRK2 NRG1 NTRK3 STAT3 TCF4 MRE11A CDK5R1 NEUROD1 GHRL RET DISC1 VLDLR RTN4 KDM1A RELN GIG8 CDK5 TCF3 PAFAH1B1 NUMB IL17A MAP2 NTRK1 NGFR BDNF NGF 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome HSPD1 NKX6-1 BMP1 MAPK1 MAPK3 TERT FDFT1 PDX1 TBX5 BLK HEL-S-130P NUMA1 PINX1 GATA4 HEPACAM2 CLDN23 C8orf7 SOX7 SLC35G5 TERF1 TLR4 TNKS PRSS55 AXIN1 NEIL2 PPP1R3B SLC2A4 SLBP CSTA MTMR8 RAF1 MTMR9 PRSS51 SGPL1 ERI1 MTMR6 S100A10 MCRS1 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 MSRA FAM167A FCGR2B FCGR2A CGAS CILIOPATHIES%WIKIPATHWAYS_20260610%WP4803%HOMO SAPIENS Ciliopathies ARL3 AK7 DYNLT2B DYNC2LI1 SUFU PKHD1 NPHP1 NPHP3 PIBF1 CEP78 KIF7 NEK9 DCDC2 CPLANE1 TMEM231 DNAAF19 TMEM17 ARL2BP NME7 TMEM237 AHI-1 UNC119 DNAL1 INVS C2CD3 DNAAF11 TCTN3 TCTN2 TTC8 TMEM107 TCTN1 HYDIN CNGA1 CC2D2A OFD1 CCDC39 CEP164 DNAI2 CFAP52 XPNPEP3 WDR35 TOPORS RP1 BBS10 EVC CLUAP1 BBS12 TULP1 RP2 TMEM216 NME9 CCDC41 EFHC1 WDR51B ZMYND10 KIZ CFAP53 CNGB1 KATNIP DNAH6 CRX PKD1L1 RSPH9 CFAP298 ARL13B TMEM67 SDCCAG8 RAB23 KIAA0753 PDE6D POC1A RAB28 DNAI1 EVC2 TUB DYX1C1 PCARE SCLT1 OCRL RSPH3 RPGRIP1 PIK3R4 TTLL5 RSPH1 ALMS1 SPAG1 HYLS1 B9D1 CEP41 B9D2 ATXN10 TRIM32 TRAF3IP1 PLK4 CENPF INPP5E DYNC2I2 IFT172 IFT80 LZTFL1 IFT81 INTU HEL-S-296 BBS2 NEK8 BBS1 DRC1 FLCN BBIP1 ADCY6 ZIC2 MKS1 IFT27 USP9X IFT52 BBS9 ZNF423 BBS7 IFT57 CEP290 PKD1 BBS5 BBS4 IQCB1 IFT140 RP1L1 IFT43 GLI3 ODAD1 ODAD3 ODAD4 CEP19 CCDC28B MCIDAS TBC1D32 NEK1 NEK2 DYNC2H1 DNAAF3 CFAP418 DNAAF2 DNAJB13 CCDC40 DNAAF6 RPGRIP1L CFAP410 FAM161A TMEM138 GPR161 WDPCP CCNQ CCNO SMO CEP104 ANKS3 ARL6 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260610%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 SIK3 SIK1 DNAJB1 SIK2 CREB1 HDAC7 GNAS CRTC2 IL3 SIGNALING%WIKIPATHWAYS_20260610%WP286%HOMO SAPIENS IL3 signaling ENPP3 PTPN6 CCR3 RAPGEF1 SOS1 CRKL INPP5D CSF2RB MAP2K1 YWHAQ SHC1 PIK3R2 MAPK8 HEL-S-1 PIK3R1 LYN MAPK1 CD69 CXCL8 MAPK3 RAF1 BAD IL5RA STAT3 PTPN11 JUN PIK3CD BCL2 GRB2 TGFB1 GAB2 VAV1 STAT5B IL3RA SYK CBL IL3 SRC FYN HRAS JAK1 BCL2L1 FOS TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260610%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CDO1 GCLC CBS GPX2 GPX1 TYMS GPX3 GPX6 PEMT CHKA HEL-S-61p MAT1A CHDH CHPT1 DHFR MTHFD1 MTHFD2 MTHFD2L HEL-75 DNMT3L DNMT3B PSPH pcap SHMT1 CTH MTR HEL-S-51e GCLM GAD2 BAAT PSAT1 HEL-S-44 AHCYL2 AHCYL1 SLC25A48 HEL-S-64p PCYT1B BHMT2 GPX7 BCAT1 HEL-S-75p MTHFD1L HEL-S-182mP CEPT1 CHKB PCYT2 PHGDH AMT GAD1 ALDH7A1 BCAT2 GPX4 AGXT2 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260610%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C PFKP HEL-S-133P HEL-S-30 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260610%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR ARL3 DYNLT2B DYNC2LI1 CEP97 IFT80 IFT74 PIBF1 LZTFL1 CPLANE1 IFT81 TMEM231 TMEM17 KIF3A C2CD3 TCTN3 TCTN2 TTC8 TMEM107 TCTN1 CC2D2A OFD1 WDR35 BBS2 DNCL1 BBS10 EVC BBS1 CLUAP1 BBS12 TMEM216 CCDC41 FUZ IFT20 ARL13B TMEM67 MKS1 RAB23 KIAA0753 IFT27 IFT25 EVC2 TTC26 SCLT1 IFT52 BBS9 B9D1 BBS7 IFT57 TRAF3IP1 BBS5 BBS4 CEP192 DYNLT1 IFT140 TTC23 CBY1 EFCAB7 IFT43 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 ARMC9 CEP19 CEP20 TEDC1 TEDC2 FBF1 KATNB1 IFT46 TUBD1 DYNC2H1 KIF3B INPP5E CEP76 RABL2B TUBE1 CPLANE2 MIB1 RPGRIP1L SASS6 IFT70B CEP162 CIBAR1 CEP44 DYNC2I2 WDPCP IFT172 CEP104 ARL6 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260610%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP1A2 EPHX1 HEL-S-166mP CYP3A4 GSTM1 CYP2A13 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260610%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX AKR1B1 TBXA2R PTGDR PTGIR ACOX1 ACOX3 PLA2G6 CYP4F12 PPARG NR1C2 PTGIS PLA2G4B PLA2G5 PRXL2B PTGES EHHADH CYP4F2 CYP4A22 CYP4A11 PTGFR PTGS2 HEL-S-298 PTGR1 HPGD PTGS1 PTGDR2 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CCNE1 CDKN1A CCND3 CDKN1B CCND1 CREB1 MYC RAD52 CDK6 H2AX ATM INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260610%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC5 PPP3R2 NFATC3 NFATC2 NFATC1 SUPT4H1 PPP3R1 NELFA HDAC8 PPP3CA NELFE HEXIM1 SUPT5H NFATC4 NFKB1 NELFCD PPP3CC EP300 SP1 NELFB RELA NFKBIA HDAC3 HDAC2 CDK9 CREBBP HDAC7 HDAC1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260610%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260610%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA9 NDUFA5 COXFA4L2 NDUFA11 ATP5G1 HEL-S-271 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ND3 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 ATP6 ATP5MC2 NDUFB2 ATP5J NDUFB10 NDUFB1 ATP5MC3 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA10 DMAC2L NDUFA7 NDUFA6 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFS8 NDUFS3 ND1 COXFA4 ATP6AP2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK10 ITGA1 SOS1 MAP2K1 ITGB1 COL1A1 MAP2K2 MAPK8 NRAS MAPK1 RAF1 EGFR PXN AKT3 MAPK14 AREG PIK3CD MAPK9 GRB2 MAPK12 MAPK13 MAPK11 SRC HRAS TLN1 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260610%WP5399%HOMO SAPIENS NPHP1 deletion syndrome INVS NPHP1 MAPK1 PTK2B RPGRIP1L MAPK3 FLNA FLNB APOPTOSIS%WIKIPATHWAYS_20260610%WP254%HOMO SAPIENS Apoptosis MAPK10 CASP2 BOK IRF-1 IRF4 HRK PRF1 CASP4 HELLS NFKBIE SCAF11 IRF2 CRADD BCL2L2 TRADD BAD TRAF1 CDKN2A TNF IKBKB IKBKG CHUK BAX BCL2L11 TRAF2 IRF3 TRAF3 RELA IRF7 TP63 IRF6 RIPK1 IGF1R FADD MAP3K1 BCL2L1 MCL1 MAP2K4 DIABLO MYC BBC3 IGF1 NFKBIB BIRC5 PIK3R1 NFKB1 APAF1 LTA TNFRSF1B TNFRSF25 BIRC2 TNFRSF21 BIRC3 JUN PMAIP1 IGF2 TNFRSF10B BCL2 MDM2 CASP6 NFKBIA CASP10 BAK1 CYCS TP73 TNFSF10 BNIP3L DFFB CASP9 DFFA CASP8 CASP3 TNFSF6 TNFRSF1A REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260610%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TRPV5 PIK3CA PPP3R1 MAP3K5 PTH FFAR3 MAPK1 SEC16B HEL-S-41 TGFBR1 APAF1 RAF1 CALCA SMAD2 MTOR ACTA2 BAX MCU PDE1B TGFB1 BAK1 CASP9 CASP8 CASP3 SMAD4 TNFSF11 TNFRSF1A PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260610%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence RB1 GNAS NRAS PTGER1 PTGER2 PTGER3 PTGIS GNAI1 ALOX15 ALOX12 ALOX15B PRXL2B IGFBP5 PTGES ADCY3 CDKN1A ALOX5 MAPK11 PTGER4 HRAS ALOX5AP SIRT1 LTC4S PTGS2 PTGS1 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260610%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway TLR7 SCARB1 TMPRSS2 CTSL SLC6A19 FURIN ACAT1 ACE2 NRP1 TMPRSS4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260610%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 MELANOMA%WIKIPATHWAYS_20260610%WP4685%HOMO SAPIENS Melanoma PIK3CA ERBB4 SOS1 ARHA PAK1 MAPK1 E2F3 MAPK3 BAD ARAF CDKN2A CALML6 AKT3 CALML3 PTPN11 CALML4 PREX2 WHR1 PDE5A BAX KIT HEL114 SOS2 PIK3CD KDR RB1 CCND1 MAP2K1 NF1 MAP2K2 SHC2 PIK3R3 PIK3R2 GRM3 PIK3R1 E2F2 NRAS RAF1 DDB2 POLK EXOC7 GADD45B GADD45A CDK4 GADD45G CDK6 MDM2 GRB2 CALM1 BAK1 CDKN1A PTEN HRAS RHOB RAC1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260610%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome LHB TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 POM121 GNRH1 ATP10A CDKN2B CDKN2A NUP88 HERC2 NUP62 AHCTF1 NUP188 NPAP1 PCM1 RNF8 NUP214 NDC1 GOLGA8S SNRPN NUP210 GOLGA6L2 TACR3 NUP93 FEZ1 FEZ2 NUP98 GABRG3 SNURF GABRG1 NUP54 NUP58 OCA2 NUP205 SLC45A2 NGF MAGEL2 SEH1L EIF4E DLX5 AAAS NUP160 NHLH2 RAE1 DKFZp781B1423 NUP42 NUP85 CYFIP1 FMR1 TPR MSX1 RANBP2 NUP155 GABRB3 NUP153 RB1 PRKCZ CDC6 KISS1 POMC GHRH CCND1 NUP35 MKRN3 CDKN2C NUP107 GABRR3 PCSK1 GABRR1 BBS4 CCND2 NUP133 UBE3A OXT GHRL TYR CDK4 INS NDN CDK6 MDM2 GABRA5 HEL-S-71 FSHB CGA BDNF NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260610%WP4220%HOMO SAPIENS Neurotransmitter disorders MAOA TPH2 DDC SLC18A2 TPH1 SLC6A3 PNMT DBH TH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260610%WP619%HOMO SAPIENS Type II interferon signaling IFNB1 STAT2 IRF-1 IRF4 IFI6 GBP1 CYBB PSMB9 IL1B IRF2 IRF8 CXCL9 IFNGR1 HLA-B SPI1 IFNGR2 STAT1 MHC2TA IFIT2 PTPN11 NOS2 EIF2AK2 IFNA2 H4C9 OAS1 IRF9 SOCS3 SOCS1 JAK1 ISG15 IFNG PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260610%WP5088%HOMO SAPIENS Prostaglandin signaling IL6 IL1B PYCARD KLRD1 CXCL9 CSF1 CCR2 NFKB1 CXCL8 PTGER2 CXCL1 TNF AREG PTGES AHR IL12A TGFB1 IFNA1 IRF7 IL17F IL17A PTGER4 CCL3 IL1A CCL2 MMP9 IFNG VEGFA NLRP3 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260610%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CTSK TNFRSF11B SP7 NOTCH1 ATG101 DKFZp762B153 CSF1 CTF1 MTOR HMGB1 SOST TRAF6 VCP CTHRC1 SMAD1 IL3 SMAD4 RUNX2 EFNB2 PER1 CRY1 NFATC1 ATG3 SMAD9 ATG10 IL6 ATG12 SQSTM1 DKFZp686F0183 DKFZp781O1323 ATG16L1 IGF1 BHLHE41 PTH RORB BMP6 ARHGAP4 FYCO1 WNT16 BMP3 RB1CC1 NPAS2 DRAM2 SEMA4D NR1D2 LEP PLEKHM1 ULK1 WNT10B BHLHB2 CALCA BMPR2 AMBRA1 PRKAA2 BCL2 TGFB1 LAMP2 LRP5 TNFRSF11A DKK1 BMP5 BMP4 BMP2 MAP1LC3A SEMA3A TNFSF11 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260610%WP5028%HOMO SAPIENS Glycine metabolism including IMDs GLDC SHMT1 AMT NFU1 HEL-S-302 DLD HSCB ISCU LIPT2 LIPT1 LIAS GCSH BOLA3 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260610%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways ACOT8 NPC2 ACOT7 EPHX2 ACOT11 ACOT12 ACOT13 SLC27A2 EBP AMACR DBP THEM5 ACOT6 BAAT CYP7A1 ACOT4 DHCR7 SLC27A5 CYP27A1 HSD11B1 HSD11B2 ACOT9 NPC1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK10 JAG2 NOTCH1 BMPR1A IHH DLL3 DLL4 PTCH1 PRKD1 PIK3CD FGF8 WNT3A SOX9 SMAD4 RUNX2 HEY2 FGFR4 PIK3R4 FZD7 HES6 FZD8 PRKDC PRKCE MAPK9 MAPK7 MAPK6 MAPK4 LRP5 PIK3R5 MAPK12 LRP6 MAPK13 MAPK11 FZD1 NOTCH3 NOTCH4 RBPJ PIK3CA FGF3 FGF4 FGF6 FGF7 FGF9 MYOD1 MAPK8 MAPK1 MAPK3 STAT1 MAPK14 FGF18 FGF10 SMAD1 FGF2 PIK3C2G PIK3C2B PRKCB PRKCI FGFR2 PRKCH PRKCA PRKCQ SMAD9 PRKCZ DKFZp781O1323 FGFR1 WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 WNT9B WNT9A WNT16 WNT8A WNT8B WNT3 WNT4 PPARG WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 FGFR3 WNT7A NOTCH2 BMPR2 GLI3 HES3 HES2 BMP4 BMP2 WNT1 SMO FZD2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260610%WP247%HOMO SAPIENS Small ligand GPCRs TBXA2R PTGDR PTGIR S1PR1 LPAR1 S1PR2 S1PR3 S1PR4 GPR50 CNR2 PTGER1 PTGER2 PTGER3 PTGER4 CNR1 PTGFR MTNR1A MTNR1B REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260610%WP51%HOMO SAPIENS Regulation of actin cytoskeleton ITGA1 MYL1 ARPC5 MYL3 GNA13 APC ARHGEF1 PIK3CD FGF8 VAV1 GNG12 FGFR4 RDX FGF16 EZR HEL70 PIK3R4 HEL-S-15 MAP2K1 MAP2K2 MOS RRAS2 ACTN1 RAF1 STM7 PXN PIP5K1A PIP4K2B PDGFA FGF13 FGF12 MAPK6 MAPK4 PIK3R5 F2R F2 RAC1 RASSF7 PIK3CA CHRM1 SOS1 FGF3 CRK FGF4 DOCK1 FGF6 CDC42 FGF7 FGF9 ARHA PAK1 CFL2 MAPK1 FGF20 FGF22 MAPK3 IQGAP1 FGF21 FGF17 EGFR FGF14 RRAS FGF19 FGF18 FGF10 HEL114 SOS2 TMSB4X ARHGAP35 MYLK CD14 PDGFRA BAIAP2 ARHGEF7 LIMK1 FGF2 PIK3C2G PIK3C2B WAS FGFR2 PIP4K2A APC2 PIP5K1C PFN1 EGF CHRM2 FGFR1 PIK3R3 PIK3R2 PIK3R1 NRAS RAC3 FGF23 FGFR3 ROCK1 ROCK2 PAK6 ACTG1 PAK4 CYFIP2 PS1TP5BP1 CHRM3 NCKAP1 CHRM4 CHRM5 MYH10 SSH2 SSH3 SSH1 BRK1 PIP5KL1 ARHGEF4 BDKRB2 FGD1 BDKRB1 CSK WASF1 WASF2 ABI2 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260610%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACAD9 NDUFAF2 TOMM70 TERF2IP NDUFAF1 SIRT6 MAVS RPS6KA1 IL6 ECSIT ACE2 TRAF3 REN TRAF6 MITA NFKB1 IL18 TERF2 TNF NLRX1 NLRP3 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma CTSK EGLN3 EP300 EGLN2 CADM2 PRCC RBX1 SFPQ COL21A1 ELOC BIRC7 TGFA TGFB1 EGLN1 CDKN1A VHL CREBBP FH SETD2 TFEB DVL2 HIF1A VEGFA PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP4784%HOMO SAPIENS Proteoglycan biosynthesis XYLT1 CSGALNACT1 EXT1 SLC35B2 SLC26A2 EXT2 CANT1 B3GAT3 XYLT2 B3GALT6 CHSY1 BPNT2 CHST14 CHST3 PAPSS2 ERYTHROPOIESIS%WIKIPATHWAYS_20260610%WP5607%HOMO SAPIENS Erythropoiesis CD34 EPO KIT HBB HBA2 TF TFRC GDF11 IL3RA HBZ HBG2 IL3 HBG1 CD79A HBE1 HBD GATA1 TNFSF6 EPOR GATA2 PTPRC KITLG NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260610%WP438%HOMO SAPIENS Non homologous end joining XRCC5 POLM POLL NHEJ1 WRN PRKDC 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ERBB2 DUSP2 ARHA MAPK1 CIAO2B MAPK3 ANKRD39 PARL CIAO1 COL2A1 ITPRIPL1 TMEM127 CNNM3 CNNM4 FER1L5 STARD7 SEMA4C ANKRD23 ARID5A ASTL NEURL3 KANSL3 PLXNB2 MMS19 SNRNP200 ZP2 ADRA2B CIAO2A COX11 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260610%WP229%HOMO SAPIENS Irinotecan pathway BCHE SLCO1B1 UGT1A1 UGT1A9 ABCC1 CYP3A4 ABCC2 UGT1A10 CES2 ABCG2 CES1 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260610%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis PPP3CC PLCG1 NFATC2 EP300 CD8B PPP3CA CD8A MEF2D ITPRIP ATP2A1 CABIN1 CALM1 ZAP70 LCK HDAC2 HDAC1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260610%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 ACAD9 TOMM70 IKBKE NDUFAF1 TMPRSS2 MAVS ECSIT RIGI REN NFKB1 NFKB2 NLRX1 TBK1 TICAM1 PHB2 ACE2 IRF3 IFIH1 TRAF3 TLR3 TRAF6 CGAS IRF7 AGTR1 MITA TLR7 AGTR2 NDUFB9 CTSL AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260610%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits CYTIP TCF7L2 VHL TCF7L1 NOTCH1 CXCR4 TNC SRC LEF1 VEGFA POSTN VCAM1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260610%WP2878%HOMO SAPIENS PPAR alpha pathway CDC2 UGT1A9 CCND1 CDK4 CYP7A1 MYC PLTP CYP8B1 CPT2 APOA2 APOC3 EHHADH APOA5 SLC27A1 CPT1A RXRA NR1H3 ACADM DBI CYP4A11 FABP1 NR1C1 KLK15 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260610%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260610%WP661%HOMO SAPIENS Glucose homeostasis INS TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260610%WP2113%HOMO SAPIENS Type III interferon signaling IFNLR1 IL10RB STAT2 IFNL2 IRF9 IFNL1 STAT1 IFNL3 JAK1 TYK2 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 PAFAH1B1 NDEL1 TUBA1A HEL-S-303 VLDLR NUDC RELN NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260610%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2A PLCB3 PLCB4 RELB PLCB1 PLCB2 MAPK8 RXRA MAPK1 CXCL8 CAMK2D MAPK3 IFNGR1 IFNGR2 STAT1 TNF IKBKB MAPK14 IFNAR2 TYK2 IFI27L2 MED1 RSAD2 OAS2 NOD2 CCL2 ISG15 PRKCB PRKCH STAT2 PRKCA PRKCQ NR1i1 PRKCZ IL6 PLCG2 TLR4 NRAS NFKB1 NFKB2 CYP27B1 CYP24A1 CD40 PLCE1 CD40LG PRKCE CAMK2G JUN RXRB RXRG SP1 TLR8 MAPK9 SP3 MAPK7 IFNA2 CAMP MAPK12 MAPK13 DEFB4B MAPK11 HRAS JAK1 IFNG TNFRSF1A APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260610%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TLR4 NFKB2 APOE SPI1 IRAK1 RELA TRAF6 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260610%WP558%HOMO SAPIENS Complement and coagulation cascades CLU C3AR1 CR1 PLAT F3 CD46 CFH C1QA CFI C5AR1 THBD SERPIND1 CR2 HEL-S-62p SERPINA1 SERPINF2 PLAUR F5 F8 F9 CPB2 SERPINC1 TFPI LMAN1 F10 PROC F7 PLG HEL-S-78p VWF C4B_2 C1QB CFD C1S F13B C6 CLTC C8G C7 F2R C9 MASP2 MASP1 F2 CFB CD55 KNG1 C1QC BDKRB1 SERPING1 KLKB1 PROS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260610%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein WDR35 DYNLT2B DYNLL2 DYNC2LI1 DNCL1 DYNC1LI2 IFT43 DYNC1I1 IFT80 DYNC1LI1 IFT81 IFT46 DYNC2H1 DYNC1H1 IFT22 DYNC2I2 IFT27 DYNLRB2 DYNLT1 IFT25 IFT140 DYNLT3 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260610%WP465%HOMO SAPIENS Tryptophan metabolism GOT2 HAAO CYP1A1 IL4I1 TDO2 DDC ALDH2 AFMID AOC1 KYAT3 KYAT1 IDO2 ALDH8A1 KYNU KMO TPH2 ECHS1 TPH1 STAT1 AOX1 AHR INMT MAOA ASMT DLD AANAT GCDH ACAT1 AADAT IDO1 FOXA2 PATHWAY%WIKIPATHWAYS_20260610%WP5066%HOMO SAPIENS FOXA2 pathway ACACA FOXA1 MTTP FASN APOB ABCC3 IRS1 ABCC2 INS SLC27A5 GSTM2 SLCO1B1 FOXO1 MLXIPL PPARGC1B FOXA2 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260610%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CCR2 CTCF EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260610%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX15 ALOX12 TRPA1 ALOX15B ACOX1 TRPV1 ACOX3 CYP4F12 EHHADH KPG_011 CYP4F2 CYP4A22 FPR2 ALOX5 CYP4A11 NR1C1 LTC4S HEL-S-298 PTGR1 NR1C2 LTB4R HPGD CAFFEINE IN NEURONS%WIKIPATHWAYS_20260610%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1A ADORA2A ADRA1D ADRA1B INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260610%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB27A RAB5A PDCD6IP RRAS2 HGS NRAS HNRNPH1 MAPK1 MAPK3 RAF1 HRAS ARAF RAB5B RAB5C RRAS ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias PTH1R BMPR1A IHH PLAT CDKN1C ADAMTS4 ADAMTS5 MGP NKX3-2 FRZB SOX6 SOX5 CAB39 PTHLH CST5 KIF3A HMGCS1 STAT1 GH1 PTCH1 FGF18 GHR ACAN COL10A1 STAT5B SOX9 FGF2 RUNX2 MMP9 IGF1R VEGFA TIMP3 DDR2 FGFR1 IGF1 PTH CHST11 BMP6 opn RUNX3 MEF2C THRA ALPL ENPP1 COL2A1 FGFR3 SCIN GLI3 IGF2 TGFB1 CALM1 BMP7 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260610%WP4400%HOMO SAPIENS FABP4 in ovarian cancer HEL-S-104 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260610%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway PIK3CA SOS1 CRK ITGB1 MAPK8 PAK1 MAPK1 MAPK3 EGFR BAD STAT3 IKBKB PTPN11 MAPK14 IKBKG CHUK BAX RELA STAT5B ANGPT4 ANGPT1 SRC ANGPT2 ERBB2 MMP2 MYC NCK1 BIRC5 PIK3R1 FOXO1 GRB14 NRAS RS1 GRB7 NFKB1 MSH2 ANGPTL1 TNIP2 TNIP3 PXN EIF4EBP1 NOS2 MAPK9 NFKBIA RAD51 GRB2 YAP1 MAPK12 CASP9 MAPK13 MAPK11 HRAS RAC1 AUTOPHAGY%WIKIPATHWAYS_20260610%WP4923%HOMO SAPIENS Autophagy ATG3 PIK3R4 ATG12 DKFZp686F0183 PRKAB2 DEPTOR ATG16L1 ATG101 PRKAB1 WIPI2 DKFZp762B153 PRKAA1 ATG14 ATG9A AKT1S1 RB1CC1 MLST8 ULK1 PRKAG1 PRKAG2 PRKAG3 AMBRA1 MTOR PRKAA2 RPTOR UVRAG SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260610%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2AC6 CDKN2D H2BC12 MAPK1 CXCL8 MAPK3 CDKN2B H2AZ2 H2AB1 CDKN2A STAT3 H2AJ ANAPC1 CCNA2 EHMT1 H3C15 RELA H3C8 UBE2E1 H4C9 H3F3B HIST1H4L RPS27A UBB UBC RPS6KA2 RPS6KA1 IL6 CDKN2C H2AX UBE2C CEBPB H2AZ1 NFKB1 H2AC19 UBE2D1 CDC23 H2AC14 H2BC26 H2BC12L H2BC21 CDC26 CDC27 HIST1H2AB VENTX JUN ANAPC7 H2BC17 H2BC13 H2BC14 H2BC15 CDK4 H2BC11 HIST1H2BE ANAPC5 CDK2 ANAPC2 ANAPC15 CDK6 ANAPC10 MAPK7 ANAPC11 FZR1 C10orf104 CDKN1A H2BC9 CDKN1B H2BC8 H2BC3 H2BC1 UBE2S IGFBP7 H2AC20 IL1A FOS OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260610%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies TNFRSF11B CTSK KAT2B HES5 NOTCH1 RB1 MSTN CSNK1A1 GSK3B MYOD1 HES1 CEBPB CEBPD opn AXIN1 PPARG WNT10B APC WNT7B SMAD2 DICER1 CEBPA HMGA2 CDK4 LEF1 ZMPSTE24 PS1TP5BP1 EMD TGFB1 MAOA LEMD3 CDKN1A LMNA TCF7L2 TCF7L1 JUNB CSNK1A1L CREBBP TARBP2 AGO2 RUNX2 FNTA BMP2 HDAC1 ICMT HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260610%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA1 ACACB ACACA HEL-S-133P KEAP1 PRKAB1 PRKAA1 EGLN1 NFE2L2 SLC11A2 RPS6 PDHA2 HIF1A PRKAG1 VEGFA VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260610%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RARB RXRA RXRB NR1B3 RXRG RARA METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260610%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260610%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PLCG1 PTPN6 NFATC2 PRKCA CD8B PPP3CA CD8A CSNK1A1 GSK3B IL2 NFKBIA CALM1 ZAP70 LCK PDCD1 PTEN NFKB1 ITK FYN GSK3A DYRK2 DYRK1A CTLA4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260610%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NFKB1 TRAF3 RELA IL1B NLRP3 PYCARD SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260610%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB PLEK HTR1A HTR2A PPP3CA ARC CRH PLCD4 NLGN1 FOS ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260610%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance PPP2CA PRKCZ IRS1 EIF2AK2 INS PDX1 MAPK8 PIK3R1 INSR SLC2A4 ACSL1 TRAF1 ERN1 TNF CD36 MAFA PRKAG3 TNFRSF1A RPS6KB1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260610%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells EPO IL6 PRLR CCND3 NRAS CCND2 AKT1S1 MLST8 IFNGR1 IFNGR2 STAT1 GH1 STAT3 AKT3 MTOR IL6R GHR CDK4 STAT5B FOXM1 RPTOR SOCS3 SOCS1 PRL HRAS CISH IFNG EPOR SOCS2 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260610%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS DERL1 HEL-S-2 NEFH PPP3CA NEFL MAP3K5 MAP2K2 HEL-S-44 APAF1 BAD GPX1 TNF TOMM40 PPP3CC MAPK14 BAX BCL2 RAB5A CASP9 SLC1A2 CASP3 CCS CASP12 MAP2K6 NEF3 RAC1 SMIM40 BCL2L1 TNFRSF1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260610%WP3645%HOMO SAPIENS NAD biosynthetic pathways SIRT4 TNKS2 SIRT6 SIRT7 NAPRT NMNAT1 TDO2 SIRT5 PARP4 SIRT2 SIRT3 NAMPT TNKS BST1 NADSYN1 SIRT1 PARP2 HEL-S-90n IDO1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260610%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MRC1 NR3C1 GAB3 PIBF1 NCR1 NCR2 NCR3 KIR2DL4 SELL CX3CL1 VCAM1 ITGA4 MADCAM1 CXCR4 CXCL8 MAPK3 TNF PGR IL10 STAT5B IL3 JAK3 CCL5 ANGPT1 CCL4 ANGPT2 CCL3 CCL2 CXCR3 VEGFA MCL1 MAP2K4 IL6 CXCL11 CXCL12 CD69 NR3A2 HLA-G IL2RG GATA2 IL2RB CCL8 CCL7 BCL2 IL4 IL15RA MAPK11 JAK1 IFNG IL1 SIGNALING%WIKIPATHWAYS_20260610%WP195%HOMO SAPIENS IL1 signaling PLCG1 MAP2K4 REL MYD88 PRKCZ ECSIT SQSTM1 HSPB2 MAP2K1 MAPKAPK2 MAP2K2 IL1B PIK3R2 MAPK8 TAB3 NFKBIB PIK3R1 MAPK1 NFKB1 MAPK3 MAP3K14 ATF2 PELI1 IKBKB IRAK2 MAP3K7IP1 IRAK3 PTPN11 MAPK14 IKBKG JUN CHUK IRAK4 MAP2K3 RELA MAPK9 NFKBIA TRAF6 MAP3K2 MAP3K7 HEL-S-71 IL1R1 UBE2V1 IL1A IRAK1 MAP2K6 MAP3K1 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260610%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B1 HSD17B2 SULT1E1 NR3A2 SLCO4A1 SLCO1A2 HSD17B3 SLCO2B1 SLCO4C1 HSD3B1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260610%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 KIT SKP2 GADD45A CSF1R MYC ABCB1 NOP2 GAB2 BCR LYL1 CDKN1B PDGFRA FLT1 FOXO3A ABCG2 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260610%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways HEL-S-87p ENPP3 PFKM BAP1 PFKP DEPTOR KDM5C EFCAB3 PBRM1 AKT1S1 RAPGEF5 SDSL PGBD5 LDHD SSPN SETD2 EGFR STAT3 ACACB ACACA ACLY MTOR EP300 FASN KCNJ2 HEL-S-162eP VHL PDGFRA CREBBP FLT1 HEL-S-30 ENO1 HIF1A HK3 VEGFA KDR PSPH SHMT1 HEL-S-51e HEL-S-133P HEL-S-68p SQSTM1 MAP2K5 PFKL PSAT1 CEP290 ALDOB BHLHE41 TSC2 KSR1 TSC1 GRB10 MLST8 CAMK1 PGM2 ENO2 ENO3 HK2 RHEB PHGDH PLOD2 PTEN RPTOR PKLR HEL-S-32 ME1 HEL-S-281 HEL-S-49 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260610%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming EGR1 MYC KLF4 TRIM71 POU5F1 SOX2 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260610%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders DPYS DPYD DHODH HEL74 TYMP UMPS HEL-S-29 RRM1 NT5C3A TYMS RRM2 RRM2B STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260610%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling PIK3CA NFYA MBTPS2 MED15 CREB1 SEC23A PRKAA1 HMGCS1 YY1 NR1H2 DBI FGF21 SAR1A INSIG1 DKFZp434B2017 RNF139 SEC23B SEC31B SEC31A CYP51A1 CDK8 ACACA SEC24C ACLY MTOR SCARB1 SCD HMGCR FASN ACSS1 LDLR FDFT1 SQLE SIRT1 GPAM PRKAB2 FDPS PRKAB1 LPL PPARG GSK3A LPIN1 PRKAG1 PRKAG2 PRKAG3 SREBF2 PRKAA2 SP1 RBP4 AMFR INS CAMP PPARGC1B MVD HEL-S-32 MBTPS1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA OXSM HTD2 MCAT MECR HSD17B12 SERINE METABOLISM%WIKIPATHWAYS_20260610%WP4688%HOMO SAPIENS Serine metabolism DHFR SHMT1 HEL-S-51e PHGDH PSAT1 TYMS PSPH RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260610%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ATF1 CREB1 CMA1 CTSG PLCB2 REN ITPR2 CAMK2D ATF2 HSD3B2 CYP11B2 CYP21A2 CREB3L3 HSD3B1 CAMK1 CALML6 CREB3L4 CYP11A1 CALML3 CREB3L2 STAR CALML4 CAMK2G ATF4 CAMK1D CAMK1G CREB3 CALM1 AGTR1 AGTR2 CREB5 ATF6B CAMK4 EGF EGFR SIGNALING%WIKIPATHWAYS_20260610%WP437%HOMO SAPIENS EGF EGFR signaling CAMK2A INPP5D PLSCR1 CREB1 RPS6KA5 ARF6 ARHGEF1 SH3GL2 GAB2 VAV1 CBL JUND MAP3K1 FOSB RPS6KB1 CBLC RPS6KA2 ITCH ATF1 RPS6KA1 CRKL MEF2D HEL-S-15 AP2A1 MAP2K1 MAP2K2 PCNA SHC1 NCK2 NCK1 HGS MEF2C RAF1 RAP1A EIF4EBP1 PLCE1 JUN PTPN5 SP1 CAV2 MAPK9 GRB2 MAPK7 MAPK4 RAB5A MAP3K2 PTEN HRAS JAK1 MAP4K1 RAC1 VAV2 FOS STXBP1 SH3GL3 SOS1 CRK CDC42 MAPK8 PAK1 NEDD4 MAPK1 PTK2B NEDD8 RICTOR IQGAP1 EGFR SYNJ1 STAT1 STAT3 PTPN11 NDUFA13 MAPK14 MTOR SPRY2 USP6NL GJA1 SOS2 INPPL1 AP2M1 RALBP1 STAMBP PXDN RIN1 STAM2 SH2D2A PLD2 ATXN2 STAT5B HEL-S-34 EPS15L1 EPN1 RALA ASAP1 AP2S1 REPS2 LIMK2 SRC PIK3C2B PRKCB PLCG1 PRKCI PDPK1 PRKCA PRKCZ TNK2 ERBB2 EGF MAP2K5 PTK6 PIK3R2 FOXO4 PIK3R1 FOXO1 GRB10 VAV3 ROCK1 COX2 RALB CSK CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases MDH2 D2HGDH ALDH7A1 GCDH ADHFE1 HEL-S-5 L2HGDH MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260610%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COL9A1 MATN1 COL9A3 COL9A2 MATN3 COMP INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260610%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions NKX6-1 MYD88 TGFBR2 CD44 CDC42 HTR7 CD68 OLIG2 IL1B CCR8 ITGA2 FOXP3 CXCL1 EGFR STAT1 TNF CTLA4 STAT3 CCR6 MBP MAPK14 IL10 IL12RB1 IL33 TYK2 IL2 STAT5B IL10RB SOX9 IL10RA PDCD1 PDGFRA SOCS3 JAK3 STAT4 IKZF2 MMP9 IGF1R CCN3 VEGFA NKX6-2 OLIG1 CNP EBI3 APOD KLRG1 SIRPA GSDMD MOG MCAM IL6 TMEM119 CXCL12 IGF1 FOXO4 TLR4 FOXO1 opn TGFBR1 NFKB1 NFKB2 CSPG4 FOXO3A FAM20C CD80 IL2RG TNFRSF1B ROS1 CD47 AREG CX3CR1 AIF1 SMAD2 IL2RA PDGFA IL2RB NOS2 NKX2-2 CCL1 IL12A CCL20 IL4 TGFB1 ITGB3 IL18 HEL-S-111 ITGAV SSTR2 JAK1 IFNG OSM RAC1 NLRP3 TGFBR3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260610%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NOD1 NLRC4 DUOX2 MEFV NLRP7 NLRP2 NLRP1 AAMP IL1B PYCARD CARD8 CARD9 ERBIN CARD6 ACAP1 AIM2 NLRP10 NAIP IKBKB NDUFA13 IKBKG CHUK RELA CASP5 NFKBIA COPS6 NOD2 CASP9 IL18 CASP8 RIPK2 NLRP3 RAC1 NLRP12 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260610%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging FOXO1 NFKB1 TFAM FOXO3A PPARG SIRT1 HIF1A SIRT3 NAMPT ROS1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260610%WP410%HOMO SAPIENS Exercise induced circadian regulation CLDN5 CRY2 CRY1 HLA-DMA UCP3 CBX3 PIGF G0S2 HEL-S-72p CEBPB TOB1 SUMO1 DAZAP2 BTG1 NR1D2 PURA STBD1 SUMO3 QK3 ERC2 GSTM3 RBPMS ZFR HEL-S-22 PSMA4 AAG1 VAPA PPP1R3C MYF6 H2BC15 PER2 NCKAP1 ETV6 PER1 KLF9 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260610%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein ITGA6 BOK BAX BCL2L12 BCL2L10 BCL2L14 BCL2A1 MYC BCL2L13 BCL2 GSK3B PTHLH BAK1 ITGB4 BCL2L2 GSK3A BCL2L1 AKT3 MCL1 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260610%WP5526%HOMO SAPIENS Age related macular degeneration MTOR PMAIP1 PRKAA2 PRKAB2 PRKAB1 PRKAA1 RPTOR PPARGC1A MLST8 MAPK3 SIRT1 HEL-S-32 PARP2 PRKAG1 PRKAG2 PRKAG3 RPS6KB1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway UGT1A1 ABCC3 CYP3A4 NCOA1 NR1I3 ABCC2 ABCB1 CYP2C19 CYP2C9 CYP2A6 RXRA FOXO1 CYP2B6 DNAJC7 PPARGC1A SULT2A1 SMC1A ALAS1 UGT1A4 UGT1A3 UGT1A9 SP1 NCOA6 EHHADH PTPA SULT1A1 CYP4A11 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5393%HOMO SAPIENS Androgen biosynthesis AKR1C1 CYP3A7 AKR1C2 AKR1C4 CYP3A4 HSD17B3 POR HSD17B4 CYP17A1 HSD17B1 HSD17B2 HSD11B1 HSD11B2 SULT2A1 SRD5A2 HSD3B2 AKR1D1 HSD3B1 LEPTIN SIGNALING%WIKIPATHWAYS_20260610%WP2034%HOMO SAPIENS Leptin signaling SOS1 CDC42 NCOA1 CREB1 ARHA PRKAA1 MAPK8 CFL2 MAPK1 MAPK3 BAD STAT1 STAT3 IKBKB ACACB PTPN11 ACACA MAPK14 IKBKG MTOR CHUK IRS1 RELA STAT5B SOCS3 SRC FYN EIF4E RPS6KB1 PLCG1 REL RPS6KA1 ERBB2 PLCG2 MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 PIK3R1 FOXO1 NFKB1 SH2B1 LEP RPS6 RAF1 GSK3A LEPR EIF4EBP1 ROCK1 ROCK2 PRKAA2 SP1 PDE3B KPNA4 KHDRBS1 GRB2 SOCS7 PTPN1 PTEN HRAS CISH JAK1 RAC1 SOCS2 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260610%WP4963%HOMO SAPIENS p53 transcriptional gene network DDIT4 NOTCH1 DEPTOR CX3CL1 PRKAA1 AKT1S1 TP53INP1 GPX1 TNF MTOR BAX XRCC5 SESN2 IRF9 CCL2 ISG15 XPC TIGAR NCF2 CCNG1 THBS1 TP53I3 PRKAB2 SLC7A11 ERCC5 PRKAB1 ULK2 PCNA BBC3 TP53AIP1 PIDD1 TSC2 AURKA SESN1 MSH2 MLST8 BTG2 APAF1 ULK1 DDB2 PRKAG1 PRKAG2 RRM2B PRKAG3 GLS2 E2F7 CCNE1 POLK PMAIP1 SFN GADD45A PRKAA2 TNFRSF10B PML CDK2 SMR3B ACAD11 CDKN1A CPT1C SERPINB5 PTEN TRAF4 SCO2 RPTOR ADGRB1 DRAM1 ZMAT3 ADORA2B PERP RPRM SIVA1 TNFSF6 FUCA1 TNFRSF10D LIF ULBP2 ULBP1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260610%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis ELANE REL MYD88 IRF-1 IL6 RELB VCAM1 MAPK8 TLR4 NFKB1 CXCL8 NFKB2 TNF IKBKB MAP3K7IP1 MAPK14 IKBKG CHUK IL10 IRAK4 TLR8 RELA TRAF3 NFKBIA TRAF6 IRF7 TLR7 MAP3K7 LCN2 CCL4 CCL3 IL1A IRAK1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260610%WP5103%HOMO SAPIENS Progeria associated lipodystrophy KCNJ6 SMAD2 MUCL3 RECQL SPRTN INS LMNB2 ZMPSTE24 WRN TGFB1 LMNA FFAR3 SMAD4 PPARG FBN1 FNTA BANF1 ICMT ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260610%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease HTT EGF CREB1 RPS6KA5 MAP2K1 MAP2K2 MAPK1 MAPK3 BDNF CASP3 RAF1 EGFR HRAS NTRK2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260610%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 ACAT1 UCP2 CPT2 SLC25A20 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260610%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation PDGFA RAB43 RASSF1 CDK4 MYC INS CDK2 PDX1 CRTC2 IGF1 FOXM1 FOXO1 MAPK1 INSR TGFBR1 FLT1 MAPK3 IGF1R AKT3 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260610%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IFNB1 MYD88 IKBKE IL6 INPP5D TRAM1 TLR4 NFKB1 CXCL8 TNF IKBKB MAP3K7IP1 TBK1 IRAK3 IKBKG CHUK IRAK4 TICAM1 TIRAP IRF3 TRAF3 NFKBIA TRAF6 IRF7 MAP3K7 IRAK1 RIPK1 RANKL RANK SIGNALING%WIKIPATHWAYS_20260610%WP2018%HOMO SAPIENS RANKL RANK signaling TNFRSF11B PLCG1 NFATC1 FHL2 RELB CDC42 SQSTM1 MAP2K1 PIK3R2 MAPK8 PIK3R1 LYN MAPK1 NFKB1 NFKB2 MAPK3 SPI1 STAT1 TRAF1 IKBKB MAP3K7IP1 MAPK14 IKBKG MTOR JUN CHUK TRAF2 RELA MAPK9 TRAF3 NFKBIA TRAF6 GAB2 TRAF5 MAP3K7 SYK TNFRSF11A CBL PAPSS2 SRC MAP2K6 RAC1 TNFSF11 FOS MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260610%WP2006%HOMO SAPIENS miR targeted genes in squamous cell TUBA1A TGFBR2 DHX57 HOXA7 GOLGA7 GAS2L1 ATP6V1F SEC23A PEDS1-UBE2V1 PRPF40A MRPS33 YWHAQ TMEM59 VCAM1 HSD17B12 HES1 CTDSP1 DNAJB1 ELOVL5 E2F3 PDLIM7 SLC12A2 GALNT7 GALNT1 POLR2C POLD2 FMNL2 CUL4B BET1 AKAP8 HEL-S-30 SDCBP FBXW11 MAP3K8 AP2A1 NRP1 CPNE8 VEZT RHEB TNFRSF10B PWP1 CIAO2A ATP6V0E1 FNDC3B FNDC3A PISD GYS1 UBE2J1 MRPL20 COMMD9 HMOX1 ATP6V1C1 ANXA2 MOV10 SYNE2 SPTLC1 ANP32B RNP24 ARF4 AXL POM121 TRAM1 NEDD4 MAGT1 MRC2 TMEM43 PPP1R7 SH3BP4 TMED7 HMGA1 CSDE1 PXDN PTMA SMAD1 MPZL1 AP3D1 FGF2 ARCN1 SPCS3 HEL-S-26 THBS1 LAMTOR5 POGLUT3 SLC38A1 RARS1 LAMC1 NCL TPM3 SRSF9 TPM1 RAI14 TMED10 CBFB PNP ADIPOR2 RTN4 GFPT1 SLC4A10 TBCA P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM ATP2A2 ADAR IL6 SIGNALING%WIKIPATHWAYS_20260610%WP364%HOMO SAPIENS IL6 signaling MAP2K4 IRF-1 SOS1 IL6 VIP NCOA1 MAP2K1 GSK3B MAP2K2 NR2F6 SHC1 PIK3R2 PIK3R1 MAPK1 MAPK3 BAD STAT1 STAT3 CRP PTPN11 IL6ST IL6R TYK2 GRB2 VAV1 MAP3K7 JUNB SOCS3 CREBBP NLK JAK1 HDAC1 RAC1 BCL2L1 TIMP1 RPS6KB1 AXON GUIDANCE%WIKIPATHWAYS_20260610%WP5289%HOMO SAPIENS Axon guidance RHOD CDC42 HEL-S-28 ITGB1 ROBO2 RYK SEMA5B ROBO3 DPYSL5 BOC MAPK1 DCC CXCR4 UNC5D SEMA7A PARD3 EFNB1 PARD6A ABLIM3 LRIG2 SRGAP2 EFNA1 TRPC1 NTNG2 PTCH1 L1CAM FES GNAI1 RRAS NGL1 SRC FYN MYL12B PDPK1 PRKCA PRKCZ NTN3 ARHGEF12 CXCL12 HEL-S-15 GSK3B NCK1 ROBO1 RAF1 WNT4 NRP1 FZD3 RGMA BMPR2 ROCK1 SLIT1 EPHA2 SLIT3 SLIT2 SHH CDK5 gdf7 EPHB1 HRAS SEMA3A PLXNA1 RAC1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260610%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NQO1 CYP1A1 GCLC TXN2 CYBB HEL-S-44 NFE2L2 NFKB1 NOX4 GPX1 GPX3 GSTT2 MAPK14 NOX3 UGT1A3 NOX5 XDH SP1 MGST1 MAOA JUNB HEL-75 TXNRD2 FOS PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260610%WP4917%HOMO SAPIENS Proximal tubule transport SLC5A5 ATP6V1C1 AQP1 ATP6V1F ABCC2 ABCB1 SLC34A3 SLC34A1 SLC9A3 SLC16A10 ABCG2 SLC2A2 SLC47A2 ATP6V1A SLC22A6 SLC47A1 SLC22A2 SLC3A1 SLC5A1 SLC5A2 SLC7A7 SLC6A20 SLC4A4 CLTRN CA4 ATP6V0A4 SLC3A2 ATP1A1 ATP6V1E1 ATP6V1D SLC22A11 ATP6V0B ATP6V0E1 SLC6A18 SLC36A2 ATP1B1 SLC1A1 HEL-76 SLC5A8 SLC6A19 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ATP6V1G1 ATP6V1B1 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260610%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CDO1 pcap CTH MTR CBS HEL-S-61p MAT1A ADK HEL-S-182mP NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260610%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1B1 CAMK2A GRIN2B CNGA3 CNGA4 PBR DLG4 GUCY1A2 PDE2A CNGB3 NEFL CREB1 PDE3A IL1B NFKB1 CAMK2D CNGA1 BAD TNF ACTN2 CAMK2G NOS2 AKAP9 BCL2 RELA NFKBIA CALM1 CNGB1 CYCS GRIN1 NPPB CASP9 NPPA IFNG NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260610%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis NOS2 PRMT6 HEL-S-277 PRMT7 PRMT2 PRMT3 CARM1 PRMT1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation FOXO1 DCN SMAD1 SMAD9 SST BCL2L11 DKK1 WNT4 DKFZp781O1323 SFRP1 BMP2 LEFTY2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260610%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 SLC44A1 CHDH TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260610%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis KLF15 CEBPG CEBPB CEBPD GATA3 DDIT3 KLF2 CEBPA KLF5 PPARG EGR2 GATA2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260610%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A PRKCB PRKCA CREB1 MAP2K1 GJB1 DRD2 PPP1R1A GNAS MAP2K2 MAPK1 DRD1 MAPK3 RAF1 ARAF GNAI1 RAP1A ACTG2 PRKACG ADCY1 ADCY8 ACTG1 PPP1CC PS1TP5BP1 CALM1 HEL-S-80p GRIN1 CAMK4 GRIA2 DRD4 GRIA3 GRIA4 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260610%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A USP1 ID1 ARCN1 GIG8 ESTROGEN SIGNALING%WIKIPATHWAYS_20260610%WP712%HOMO SAPIENS Estrogen signaling MAPK14 GNB1 IKBKG JUN CHUK PIK3CA SP1 CREB1 MAP2K1 BCL2 MAPK9 GNAS GPER MAPK1 NFKB1 GNGT1 IKBKB FOS DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260610%WP710%HOMO SAPIENS DNA damage response only ATM dependent MAPK10 PIK3CA SOS1 CDC42 ARHA MAPK8 MAPK1 BAD APC DVL3 CDKN2A AKT3 BAX HMGB1 SOS2 BCL2L11 IRS1 PPP2R5E LDLR PIK3CD LEF1 PPP2R5C WNT3A RBL2 TCF7L2 TCF7L1 BCL6 SMAD4 PIK3C2G MAP3K1 FOSL1 PIK3C2B PIK3R4 CCND1 ERBB2 MYC GSK3B WNT2B PIK3R3 MLKL BBC3 SHC1 PIK3R2 BIK WNT5B CCNG2 PIK3R1 CCND3 G6PC1 CCND2 WNT16 NRAS AXIN1 INSR NFKB1 NFKB2 RAC3 FOXO3A WNT3 WNT4 DVL2 WNT10B PCK2 WNT10A WNT7B WNT7A JUN PMAIP1 FRAT1 BCL2 MAPK9 MDM2 GRB2 TGFB1 ATM BAK1 TP73 CDKN1A CDKN1B MAP3K7 PIK3R5 PTEN HRAS TNFSF6 DVL1 WNT1 RAC1 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260610%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMNAT3 NAPRT HAAO NMNAT1 TDO2 NMNAT2 AFMID NAMPT KYNU NMRK2 NMRK1 KMO NADSYN1 AADAT HEL-S-90n IDO1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260610%WP2023%HOMO SAPIENS Cell differentiation expanded index HDAC5 MEF2B MEF2D KLF4 TLX3 SOX2 MYOD1 GIG8 TLX2 LEFTY1 PAX7 TLX1 MEF2C RUNX2 STAT3 LEFTY2 EZH2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260610%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling RELB GSK3B MAPK8 NFKBIB MAPK1 NFKB1 NFKB2 MAPK3 TNFRSF12A MAP3K14 RAF1 TRAF1 TNF IKBKB BIRC2 MAPK14 BIRC3 JUN CHUK TRIM63 TRAF2 RELA MAPK9 TRAF3 NFKBIA TRAF5 MAP3K7 CASP8 CASP3 HDAC1 RIPK1 FADD TNFSF12 RAC1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260610%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R2 PTPN11 PPP2CA PTPN6 PIK3R1 HLA-DRB1 PIK3CA PIK3CD CD80 CTLA4 PIK3R3 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260610%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway PDPK1 HTR1A PIK3CA HTR2A CREB1 RPS6KA5 MAP2K1 MAPKAPK2 MAP2K2 ARHA RASGRF1 MAPK1 MAPK3 HTR1E HTR1F GNAO1 HTR1D HTR1B STAT3 GNAI1 RAP1A MAPK14 MAP2K3 GNAI3 MAP2K6 MAPKAPK3 MAP3K1 FOS METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260610%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX15 ALOX12 FADS1 ALOX5 FADS2 PTGS2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260610%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development DCAF7 HES5 DNER NOTCH1 REST CREB1 DEPTOR CSNK1A1 HES1 AKT1S1 RBBP4 MTOR SPRY2 RBL2 H3F3B FGF2 SIRT1 CRY2 NFATC1 PSENEN BACE1 APP CCND1 TFDP1 PSEN1 TFDP2 GSK3B TSC2 LIN9 TSC1 LATS2 FOXO1 MLST8 LIN54 GMNN LIN52 TFDP3 AMPH LIN37 TFAP4 NEUROG2 E2F5 CDK4 CDK6 RBL1 CDKN1B RPTOR E2F4 CASP9 CASP3 DYRK1A EIF2B5 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260610%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system TUBA1C KAT5 MYD88 ADRBK1 HTT NR3C1 TUBB CFTR HEL-S-2a DCTN1 SIRT2 TUBA4A SNCA PARK2 MAPK8 TUBA2 MAPK1 FOXP3 PTK2B MAPK3 EGFR APC EP300 BAX BBIP1 VCP VHL GRIA2 APOE HIF1A ISG15 CDC20 DLG4 PRKCZ MAP3K5 MAP1B SQSTM1 GSK3B CYBB HEL-S-44 HEL-S-72p BIRC5 AURKA TWIST1 ERG GSK3A OPTN PXN SMAD2 HDAC11 PRKCE IKBKAP RHOT1 CD133 FAT10 MYH9 MAPRE1 SHH ITIH4 SP1 NEDD9 KALRN HEL-S-67p BCL2 ATXN3 HSF1 EP400 CCDC141 HSPA4 FUS FREP1 MIIP ELP3 HEL-S-102 ARID3A SGK1 SNCAIP CSNK2A2 GARS1 CNOT6 BDNF DLG2 STUB1 POU5F1 TARDBP MAP1LC3A HEL-S-32 CSNK2B HEL113 RAC1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260610%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHGEF2 TP63 IRF6 ARHGAP29 TFAP2A ARHA CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260610%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CAMK2A PLCB3 HEL-S-93 PRKAR1B HEL2 PRKAR1A GJA5 GNAS YWHAQ ATP2B1 HEL-S-1 YWHAG CAMK2D DKFZp686L0365 GJB2 GNGT1 PRKD1 GNAZ GNAI3 PLN CACNB1 CACNB3 HEL-S-99n GNG3 ATP1B1 CACNA1B GNG5 CACNA1A GNG4 FKBP1A GNG7 FXYD2 GNG8 KCNJ3 GNG12 GNG11 GNG13 GJB6 GNB2 CACNA1S GNB1 GNB5 GJB1 CAMK1 PRKCE SFN GNA11 CALM1 GJA3 GJA4 GJA9 GJA8 ATP1B3 ATP1B2 STIM2 CHRM1 GJC1 GJC2 RGS16 GJB4 GJB3 GJB5 ANXA6 GJD2 ADRB3 CASQ2 CASQ1 ATP1A4 KCNJ5 KCNB1 ATP2B3 ATP2B2 RYR1 GNAO1 RYR2 RYR3 GNAI1 GNB4 GJA1 ADCY3 ADRA1D ADRB1 ADCY1 ADRB2 ADCY8 ADCY6 ADCY5 ADCY9 GNG2 PRKCB PRKCH PRKCA PRKCQ PRKCZ ADRA1A CHRM2 SLC8A1 RGS4 RGS5 RGS2 RGS1 RGS6 ITPR2 GRK5 GRK4 PKIB PKIA PKIG ORAI1 CACNA1C RGS18 RGS17 RGS20 CAMK2G RGS10 RGS11 ADRA1B GNB3 CHRM3 CHRM4 CHRM5 CAMK4 ATP2A2 RGS14 ATM SIGNALING%WIKIPATHWAYS_20260610%WP2516%HOMO SAPIENS ATM signaling CASP2 CHEK2 CREB1 CHEK1 H2AX CRADD PIDD1 TLK1 ATF2 NBN MDC1 SMC1A MRE11A CCNE1 IKBKG CCNB1 JUN RAD50 CDC2 GADD45A CDK2 MAPK9 MDM2 RAD51 TP53BP1 ATM TP73 CDKN1A RAD9A BRCA1 RIPK1 DKFZp781B1423 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260610%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging MTOR FOXO1 PTEN SIRT1 IGF1R CYTOSINE METHYLATION%WIKIPATHWAYS_20260610%WP3585%HOMO SAPIENS Cytosine methylation MBD3 TDG TET2 HEL-S-26 TET1 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260610%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1B1 CAMK2A GRIN2B PDE7B GUCY1A2 PDE7A PDE2A CREB1 PDE3A DRD2 PDE11A PDE6C DRD1 PDE6A PDE6H PDE6G PDE10A CHRNA7 PDE12 PDE9A PDE4B PDE4A PDE8A PDE5A PDE4D ADCY3 ADCY1 PDE1C PDE1B PDE3B ADCY8 PDE1A ADCY6 ADCY5 HEL-S-7a ADCY9 GRIN1 PPP1R1B ADORA2A PRKG1 PDE6D FANCONI ANEMIA%WIKIPATHWAYS_20260610%WP5465%HOMO SAPIENS Fanconi anemia SLX4 ERCC1 UHRF1 CEBPD NBN FANCG EGFR DCLRE1B CTDP1 UHRF2 MRE11A FANCD2 FAAP24 MEN1 FANCM CENPX RAD50 FANCL REV1 SMARCA4 FANCB FANCE FANCF MAD2L2 RAD51C BRIP1 UBE2T FAN1 CENPS RAD51 ATM ATR USP1 FANCA MCM2 PTEN PALB2 BRCA1 RFWD3 HEL-S-125m BRCA2 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260610%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF1 SDHD SDHAF4 SDHA SDHB SDHAF2 SDHAF3 SDHC PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260610%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBB PINK1 CASP2 LRRK2 DDC SLC6A3 SNCA HEL-117 PARK2 TH HTRA2 APAF1 SEPT5 CCNE2 UBE2L6 CCNE1 MAPK14 HEL-S-67p CASP6 ATXN2 CYCS UBA7 UBE2J2 UBE2L3 GPR37 UBE2G1 SNCAIP MAPK12 CASP9 UBE2G2 MAPK13 MAPK11 EPRS1 CASP3 SYT11 UBE2J1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2853%HOMO SAPIENS Endoderm differentiation NOTCH1 BMPR1A NR3C1 PTHLH NOG CAND1 LRPPRC APC ATP8B2 ACACA CUL4B CRTC1 MAP2K3 PIAS1 SMAD4 NLK AEBP2 DNMT3B EZH2 FOXA1 APP NKX2-1 DUSP4 DUSP2 SESN1 SMAD2 PLCH1 SOX17 CER1 DKK1 C1QBP SFRP1 BPTF GDF3 NODAL ELAVL1 WWC1 CTBP2 OTX2 TBX21 SOX21 PAX3 CEP250 WDHD1 FOXH1 STAT1 EMSY TCF4 WDFY2 BCORL1 TOX GATA6 MBTD1 EPB41L5 UBR5 PBX3 ZFHX4 MAD2L2 NABP2 TRIM71 EXT1 BCAR2 LEF1 PHF6 ZIC3 TRIM5 TCF7L1 JARID2 SLC2A12 TET1 PARP8 HOXA1 TOX3 SFMBT1 CDYL RFX7 AHDC1 FOXA2 RAB38 CTR9 PRDM14 ZNF462 RTF1 ELP4 SIAH2 ZIC5 FOXN3 SP4 LHX1 PAF1 TAF4B TCF2 ONECUT1 HOXC11 CDC73 SOX2 HHEX DUSP5 GATA4 Pax9 PABPC1 BTAF1 SOX7 TCEAL2 LEO1 FOXO1 KDM4A TNRC6C LAMC1 WNT8A CEBPZ TAF5 WNT3 VAV3 PBX1 RGS10 TGFB1 BMP7 NR1B3 MIXL1 POU5F1 PPAR SIGNALING%WIKIPATHWAYS_20260610%WP3942%HOMO SAPIENS PPAR signaling UCP1 UBC PDPK1 ACOX1 FADS2 HEL-S-28 CYP8B1 SLC27A5 CYP27A1 LPL RXRA PCK1 HEL-S-104 AQP7 DBI OLR1 FABP1 PPARG ANGPTL4 PCK2 ACSL1 NR1C2 CD36 SLC27A4 SCD RXRB RXRG CYP7A1 PLTP CPT2 APOA2 APOC3 EHHADH APOA5 SLC27A1 CPT1C PLIN1 NR1H3 CYP4A11 NR1C1 ME1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260610%WP185%HOMO SAPIENS Integrin mediated cell adhesion MAPK10 ITGA6 ITGAX RAPGEF1 ITGA1 SOS1 CRK DOCK1 CDC42 HEL-S-28 ITGB1 RHO ITGA4 ITGA2 PAK1 ITGB7 MAPK1 ITGAM ARAF AKT3 MYLK2 ITGA2B HEL114 SELENOP MAP2K3 CAPN10 ARHGEF7 SRC FYN TLN1 MAP2K6 PDPK1 VASP MAP2K5 MAP2K1 MAP2K2 SHC3 SHC1 PIK3R2 ITGB4 ITGB8 RAC3 ITGB6 RAF1 ITGAE VAV3 MYPN CAPN9 CAPN6 PXN CAPN7 ITGA7 CAPN5 RAP1A TNS1 GIT2 CAPN11 ROCK1 ROCK2 CAV3 CAV2 CAPN3 PAK6 PAK4 MAPK7 GRB2 MAPK6 MAPK4 ZYX MAPK12 ITGB3 ITGAV HRAS CSK RAC1 VAV2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260610%WP5428%HOMO SAPIENS FGFR4 p G388R signaling IL10 STAT3 FGFR4 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260610%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP46A1 CYP2C19 CYP17A1 CYP4F12 CYP2C9 CYP27A1 CYP2R1 CYP2A6 CYP2B6 CYP3A43 CYP26C1 CYP11A1 CYP51A1 CYP4F3 CYP1A2 CYP1A1 CYP1B1 CYP3A4 CYP8B1 CYP2E1 CYP27B1 CYP24A1 CYP11B2 CYP2S1 CYP26B1 CYP4Z1 CYP3A7 CYP4V2 CYP7B1 CYP2A7 CYP2U1 CYP4F22 CYP26A1 CYB5R1 CYP7A1 CYB5R4 POR CYP4X1 CYB5R3 CYP2F1 CYB5B CYP2J2 CYP4F11 CYP4F8 CYP2W1 CYP27C1 CYP20A1 CYP4F2 CYP4A22 CYP2C18 CYP4A11 CYP2A13 IL17 SIGNALING%WIKIPATHWAYS_20260610%WP2112%HOMO SAPIENS IL17 signaling PIK3CA GSK3B NFKBIB CEBPB CEBPD MAPK1 NFKB1 MAPK3 MAP3K14 IL17RC IL17RB STAT3 IL17RA IKBKB IKBKG SP1 IL25 RELA TRAF3 TRAF6 IL17F IL17D IL17C MAP3K7 IL17B TRAF3IP2 IL17A JAK1 CELL CYCLE%WIKIPATHWAYS_20260610%WP179%HOMO SAPIENS Cell cycle CDK7 CDKN2D HEL-S-93 HEL2 CDKN1C YWHAQ HEL-S-1 YWHAG WEE1 E2F3 ANAPC1 EP300 HDAC2 SMAD4 SKP1 ORC1L RB1 SKP2 CCND1 CHEK2 MYC CHEK1 TFDP1 TFDP2 PCNA TTK CDC45 CCND3 E2F2 CCND2 CDC25B CDC23 SMC1A PRKDC CCNE2 CCNE1 PTTG1 CDC27 CCNB3 CCNB2 SMAD2 CCNB1 ANAPC7 PLK1 SFN CDC2 SMC1B GADD45B GADD45A STAG2 CDK4 ESPL1 ANAPC5 GADD45G CDK2 ANAPC2 CDK6 MDM2 ANAPC10 ANAPC11 ATM FZR1 ATR CDKN1A CDKN1B SMC3 RAD21 CDKN2B MAD1L1 CDKN2A CCNA2 MAD2L2 RBL2 CCNH MCM7 CDC20 STAG1 CDC6 RBX1 CDKN2C GSK3B E2F5 MCM3 MCM5 MCM6 TGFB1 RBL1 MCM2 CDC14B E2F4 PTTG2 ANAPC13 PKMYT1 ORC6 ORC3 ORC2 HDAC1 DBF4 WEE2 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260610%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes TUBA1A DHX57 GOLGA7 GAS2L1 ATP6V1F PEDS1-UBE2V1 PRPF40A MRPS33 TMEM59 VCAM1 ITGA2 PRIM1 TYMS POLR2C POLD2 EHMT1 AKAP8 POLE4 POLA2 NARS1 RAB23 DNMT3B EZH2 MCL1 PPP5C PPP3R1 MAP3K8 BACE1 CXCL12 LPL VPS39 NRP1 TCL1A RAB5C CAP1 SNAP23 CPNE8 VEZT MTRR TMEM41B MTX1 CLDN1 BACH1 PWP1 CHORDC1 RAVER2 MAPK7 CIAO2A SEC62 CDK5RAP3 MBNL1 ATP6V0E1 HEL-S-303 CACNA2D1 IFRD1 MAPK12 FNDC3B FNDC3A C1QBP PISD CARHSP1 GYS1 WDR82 FAR1 RHOB HACD3 UBE2J1 DCAF7 MRPL20 COMMD9 RDH10 GRPEL2 HMOX1 ATP6V1C1 SNX6 ANXA2 GSTM4 RAB27B MOV10 NCEH1 PDE3A SFXN1 STRN ANP32B RNP24 ARF4 AXL DDX5 POM121 TRAM1 NEDD4 GFM1 ASH2L MAGT1 PTPRF MRC2 PANX1 COIL SERP1 IQGAP3 TMEM43 EGFR TMED3 DHX15 PPP1R7 GNPNAT1 NELFCD SH3BP4 TMED7 CTSC MRPS24 LAMTOR3 ELMOD2 TMT1A AP3B1 SLC7A6 CDCP1 CSDE1 FRG1 PXDN PTMA AMIGO2 PPP2R5C NAPG PTPA NT5E PGRMC1 USP1 SHOC2 SRSF10 COL4A2 MPZL1 SPRYD4 AP3D1 TTC9C ARHG ARCN1 WDR11 SPCS3 DOCK5 TPPP3 GPAM NFIA SNX15 SLC25A22 PKN2 LAMTOR5 TUSC2 TNLG5A LTN1 PPP3CA CPOX ARID4B TXN2 FADS2 ABHD10 POGLUT3 KPNA3 MYLIP TNFRSF10A SLC38A1 RARS1 ATG9A SNAP29 STX7 UBE4A LAMC2 CDKAL1 LAMC1 HEL-S-66 KCNN4 RAB30 SYPL1 GPD2 NCL PPIF GEMIN7 PPIB ABCG2 SRSF9 RAI14 NOTCH2 TMED10 CBFB SLC1A4 ADIPOR2 RTN4 CORO1C CD164 BRPF3 GFPT1 SLC4A10 TBCA IGF2R GNL3L P4HA2 CHMP2A SRPRB NF2 DKFZp761E1322 PICALM SLC25A1 CALCOCO2 DOCK7 TNFAIP2 ATP2A2 SSNA1 ADAR CYR61 SERPINE2 SYNE1 RRP8 TMEM109 LOC541469 ACP2 HOXA5 SCYL1 OTULINL HSDL1 HEL-S-47e FXR2 NOTCH1 TGFBR2 CEP72 RCN2 VTI1B RFT1 HARS1 RBMS1 BRI3BP FERMT2 CDKN1C SLC25A13 HOXD8 SEC23A RCOR1 LUZP1 MEOX2 NUFIP2 PTRH1 NXN VAMP3 PTBP1 YWHAQ UHRF1 TAF9B HSD17B12 TRMT1 ATAT1 GNA13 TRIP13 DNAJB1 LY6K CAND1 PHC2 GEMIN2 TDG ELOVL5 MSI2 TP53INP1 ARID2 FADS1 IGF2BP1 NPR3 E2F3 SAC3D1 ZNF622 MENT CDIPT ADPGK PDLIM7 UTP15 SLC25A24 MARS2 SLC12A2 RBM19 GALNT7 ANAPC1 UNC93B1 NHERF2 PLAG1 GALNT1 MRM1 CYP51A1 ABHD11 ABCF2 SLC4A7 RQCD1 MYO1E FMNL2 SLC25A32 CUL4B BET1 IRS1 MTHFD2 BCL6 HEL-S-30 EIF4E SDCBP FBXW11 ATG3 RB1 CCND1 AP2A1 PSAT1 SUCLG2 SMC1A AURKB PLK1 RHEB TNFRSF10B BCL2 CDK6 CDKN1A CDKN1B UBE2S BDNF NT5C3A ARID1A MYB CHAF1A SYNE2 PLXND1 SPTLC1 CDKN2A HMGA1 MAPK14 TERT KIT SMAD1 CSNK1D FGF2 PRKCI HEL-S-26 CYP1B1 CEBPB HEL-S-273 MPDU1 PURA HEL-S-108 TRPV6 TPM3 TPM1 PNP LMNB2 ARL10 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260610%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKG MUC1 CHUK NFKB1 IL6 TNF RELA IKBKB NFKBIA AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260610%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PIK3CA ELAVL1 PLCB1 CAB39 STK11 PRKAA1 STRADB ADIPOR1 ACACB PRKACG ACACA MTOR LIPE STRADA CCNA2 HMGCR INS-IGF2 FASN SLC2A4RG PIK3CD HNF4A RPS6KB2 RPS6KB1 ADRA1A EEF2K PRKAB2 PRKAB1 EEF2 CRTC2 PIK3R3 PIK3R2 CPT1A TSC2 PIK3R1 TSC1 CAMKK1 CAMKK2 INSR SLC2A4 LEP PRKAG1 PRKAG2 PRKAG3 LEPR EIF4EBP1 CCNB1 ADIPOR2 PRKAA2 ADRA1B CDKN1A CPT1C GYS2 RPTOR PPARGC1B GYS1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260610%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 ELANE CD34 RBPJ NOTCH1 BMPR1A NR3C1 FOXE1 WIF1 EGFR TCF4 GATA3 HR Nbla10317 HOXC12 KRTAP3-3 PHLDA1 EGR2 MSX2 LEF1 KRTAP15-1 SPINK6 CTGF SPINK5 ATL1-beta ADAMTS20 DSG1 SOX9 TP63 GAS1 DSG4 DSC2 SMAD1 ZBTB16 GPR49 DLX3 KLK5 KLK4 SMAD4 LRIG1 KRTAP6-1 KRTAP2-4 GSDMA GTPBP4 KLK13 FOSB FOXQ1 KLK14 FOXN1 GJB6 KRT19 MSX1 NFATC1 GPRC5D SOX2 IGF1 S100A4 BMP6 RUNX3 KLK6 NFKB1 DKK3 KRTAP8-1 ADAM17 NOTCH2 JUN CD133 IGFBP5 CD200 CASP14 SOSTDC1 TCF3 FST DKK1 PERP BMP4 DKK4 SFRP1 IFNG FZD1 FOS KITLG BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260610%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment HEL-S-47e HEL-S-93 HEL2 CREB1 MAPKAPK2 YWHAQ HEL-S-1 YWHAG TRADD PARD6A BCL2L11 IRS1 PIK3CD TRAF6 EIF4E FADD MAP3K1 RPS6KB1 NPTX2 SMPD1 FRS2 MAP3K5 MYC HEL-S-15 MAP2K1 EEF2 MAP2K2 SHC1 SH2B2 RAF1 APAF1 LINGO1 SORT1 NTRK2 KIDINS220 TIAM1 EIF4EBP1 PRKCE JUN BCL2 NFKBIA GRB2 MAPK7 CYCS CASP9 NGFR CASP8 MAPK11 BDNF HRAS RAC1 PIK3CA RAPGEF1 SOS1 CRK CDC42 ARHA MAPK8 PAK1 CFL2 MAPK1 MAPK3 PARD3 IQGAP3 BAD STAT3 IKBKB PTPN11 IKBKG MTOR CHUK BAX ARHGAP35 LEF1 PARD6B TCF7L2 TCF7L1 LIMK1 RPS6KB2 MAP2K4 PRKCB PLCG1 PRKCI WASL PRKCH PDPK1 PRKCA PRKCZ MAP2K5 EEF2K GSK3B RTN4R NRAS FOXO3A ROCK1 ROCK2 TP73 BMP7 DOCK7 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260610%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IFNB1 TYROBP REL MYD88 PIK3CA FCER1G IL6 PLAT LBP ARHA FGA TLR4 NFKB1 PLG ITGAM HEL-S-78p CXCL3 TNF IKBKB IRAK2 IKBKG CHUK NOS2 TICAM2 IRAK4 TICAM1 TIRAP IL12B IRF3 RELA TLR3 CD14 TRAF6 SYK SRC IRAK1 CCL2 LY96 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members SKP1 ZC3HAV1 MAVS TIPARP RELB PARP16 RBX1 PARP12 PARP10 RIGI GSK3B TFPI2 NFKB2 MAP3K14 CLDN6 ERN1 IKBKB TBK1 IKBKG CHUK EP300 NFKBIA BTRC CREBBP PARP14 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members SKP1 PLK1 BTRC AXIN1 RBX1 TNK2 PARP10 TNK1 APC DVL2 DVL1 DVL3 SIGNALING LIPIDS%WIKIPATHWAYS_20260610%WP5584%HOMO SAPIENS Signaling lipids ALOX15 EPHX2 ALOX12 PRXL2B CYP7B1 PTGES COX1 CYP7A1 PLA1A CYP8B1 FADS2 PLCB1 CYP2C9 CYP27A1 CYP2B6 CYP4F2 PLA2G1B GPX4 ALOX5 LTC4S PTGS2 HPGD NRF2 PATHWAY%WIKIPATHWAYS_20260610%WP2884%HOMO SAPIENS NRF2 pathway SLC5A5 TGFBR2 EGR1 TXN DNAJB1 GPX2 GPX3 GSTT2 AGER SLC5A1 SLC5A2 SLC6A20 SLC6A13 SLC6A11 SLC6A18 SERPINA1 SLC5A8 GCLM SQSTM1 SLC39A9 FTH1 SLC7A11 SLC39A6 SLC39A5 TGFA SLC39A8 GSTM2 SLC6A17 SLC6A16 HGF SLC5A7 SLC5A9 CES8 EPHA3 HEL-S-10 MGST3 MGST2 ADH7 SLC5A3 SLC5A4 NRG1 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SLC6A9 GSTM5 SRXN1 SLC2A6 EPHA2 SLC6A2 SLC2A7 UGT2B7 SLC2A8 SLC2A14 SLC2A11 SLC2A10 SLC2A13 FGF13 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 SLC39A12 ALDH3A1 SLC39A14 SLC39A2 SMVT SLC39A1 CES3 SLC5A12 SLC39A3 SLC5A10 GSTA5 GSTA4 GSTA3 CYP4A11 GSTM1 ME1 HBEGF HMOX1 UGT1A1 NQO1 KEAP1 GSTM4 GCLC ABCC3 ABCC2 CYP2A6 RXRA FTL NR1C2 UGT1A4 UGT1A3 HSP90AB1 UGT1A9 UGT1A7 SLC2A12 SLC6A8 SLC6A19 HEL-75 HEL126 PTGR1 CES2 CES1 SLC6A3 MAFG MAFF NFE2L2 SLC2A4 GSTM3 SLC2A2 HEL-S-22 SLC2A3 TGFB1 ABCC5 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260610%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 AGTR1 AVPR1B ACE2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2276%HOMO SAPIENS Glial cell differentiation CNP MBP FREP1 HEL70 GAP43 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260610%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i1 ABCC3 CYP3A4 ABCC2 NR1I3 BAAT CYP7A1 ABCB1 NR1i2 NR1H4 ABCB11 SLCO1B1 SULT2A1 SLC51A SLC51B DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260610%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV CAMK2A GRIN2B CYFIP1 FMR1 ARC SYNGAP1 YWHAG NRXN1 NRXN2 MAPK1 CAMK2D MAPK3 RYR2 TJP1 SHANK1 NRXN3 RPH3A CAMK2G STX1A DLGAP1 GRIN1 DLG2 NLGN3 NLGN2 NLGN1 HOMER1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260610%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy RASGRF1 NFKB1 PPP3R1 MYEF2 STAT3 TGFB1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260610%WP3676%HOMO SAPIENS BDNF TrkB signaling PLCG1 DLG4 RPS6KA1 SOS1 ARC EEF2K CREB1 MAP2K1 SHC1 TSC2 TSC1 NRAS MAPK1 NTRK2 EIF4EBP1 MTOR RHEB ADCY1 GRB2 GAB2 GRIN1 BDNF HRAS TRPC6 TRPC3 HOMER1 RPS6KB1 RETINOL METABOLISM%WIKIPATHWAYS_20260610%WP5188%HOMO SAPIENS Retinol metabolism SDR16C5 AWAT2 CYP3A7 BCO1 CYP1A1 RPE65 AOX1 RDH12 LRAT CYP2A6 CYP2W1 DHRS9 HEL-S-53e DHRS4 ADH1A PNPLA4 ID SIGNALING%WIKIPATHWAYS_20260610%WP53%HOMO SAPIENS ID signaling ELK3 CCNE1 PAX8 PAX5 RB1 ID1 CDK2 MYOD1 RBL2 GIG8 ID3 RBL1 PAX2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260610%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB HEL-S-111 HEXA GLB1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260610%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 MAVS IL6 CXCL11 RIGI IRF3 TLR8 IFIH1 TLR3 IL1B CGAS MITA TLR7 CXCL9 CSF2 NFKB1 IL18 CCL2 TNF ALLOGRAFT REJECTION%WIKIPATHWAYS_20260610%WP2328%HOMO SAPIENS Allograft rejection TUBA1B HLA-DQB1 HARS1 IL22 HLA-DMA HLA-DMB ABCB1 PRF1 GNLY MICA IL1B CXCL9 C1QA HLA-DPB1 FOXP3 CXCL8 PECR CXCL13 STAT1 TNF CTLA4 CXCR5 CCL19 IL10 IL2 CCL21 PDGFRA HEL-S-62p VEGFA IL-21 LRRK2 PRKCZ CXCL11 CXCL12 C4A HLA-DOA HLA-DOB HLA-B HLA-C CD40 BHMT2 CD80 HLA-A HLA-F HLA-G HLA-E C4B_2 IL5 C1QB CD40LG IL2RA HLA-DQA2 HLA-DQA1 HLA-DRB5 IL12B IL12A IL4 IL13 TGFB1 AGTR1 C8A C6 HLA-DRB1 C7 C9 IL17A CASP9 CSNK2A2 CASP8 CASP3 GABPA CD55 IL1A C1QC TNFSF6 HLA-DPA1 IFNG GDNF HEL113 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation MEF2B POU2F2 IRF4 IL6 MYC TNFRSF13C CD79B SPIB BCR POU2AF1 IRF8 TLR10 CCND3 LYN TLR4 CCND2 NFKB1 CD79A MEF2C SPI1 CD40 CDKN2A STAT3 TCF4 IL21R TLR9 TLR8 TLR5 TLR3 ID3 TCF3 TLR7 CDKN1A CDKN1B SYK BCL6 TLR1 BCL2L1 EZH2 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260610%WP5546%HOMO SAPIENS 22q11 2 distal CNV CAMK2A ELOC SNRPB2 RPS15 RPS14 RPS17 RPS16 CD79A RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 GNAZ RPSA SNRNP200 PDIA2 XBP1 SOX9 HEL-S-99n RSPH9 CBL DNAJB11 RPS15A RPS3 RPS2 RPS27A RSPH3 SNW1 RPS26 RPS28 RPS29 CHEK1 RPS20 FAU RPS21 RPS24 RPS23 ARIH1 RPS6 CAMK1 MDM2 HEL-S-125m HEL-S-89n CD79B PARK2 BCR PAK1 NEDD4 RNF19B VPREB1 SNRPD2 MAPK1 SNRPD1 CWC22 ROPN1L SNRPD3 RSPH6A XAB2 CRNKL1 PDIA4 RAB36 SNRPG PPIE SNRPE DYDC1 SNRPF SNRPB UBA6 CABP1 PRPF8 AK8 SDF2L1 CWC15 WDR57 TDRD3 RSPH14 HYOU1 GGTLC2 ZNF280A IQUB DHX16 PTPA HEL-S-107 CCDC116 BUD31 UBE2L3 PLRG1 NME5 YDJC CANX SNRPA1 RBM22 AQR SF3B5 SF3B2 LRP4 PPM1F RNF113A RILP UGGT1 PPIL1 SF3A1 SF3A2 CDC5L IGLL5 PHF5A RBX1 IGLL1 YPEL1 PPIL4 PPIL6 UBE3A PPIB DNAJB13 CAMK4 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260610%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer ALK JUN SOS1 SOS2 GAREM2 MYC MAP2K1 MAP2K2 SHC1 KSR1 MAPK3 RAF1 FOS PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260610%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260610%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HAMP BMP6 ID1 TMPRSS6 HFE ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260610%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism ABCG8 FDPS ABCG5 MVK HSD17B7 TM7SF2 PMVK DHCR24 DHCR7 ACAT2 NPC1L1 HMGCS1 MGAT1 FABP2 DKFZp434B2017 CD36 SLC27A4 CYP51A1 MTTP HMGCR EBP APOB LDLR ABCA1 FDFT1 DGAT1 LBR APOA4 SQLE SC5D MSMO1 MVD CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260610%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia REL IL6 RELB MSTN IL1B IGF1 CEBPB AKT1S1 NFKB1 NFKB2 MLST8 TNFRSF12A FOXO3A TNF STAT3 IKBKB IKBKG SMAD2 MTOR CHUK EP300 TRIM63 IL6R FBXO32 RELA ACVR2A NFKBIA IL1R1 RPTOR MAPK11 SMAD4 IL1A JAK1 MAP1LC3A IGF1R TNFSF12 TNFRSF1A FOXP3 IN COVID 19%WIKIPATHWAYS_20260610%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6ST STAT5B IL2RA IL2RB IL7R FOXP3 IL6R IL6 CD80 STAT3 IL2RG IL2 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 MSRB3 MSRA CYP1B1 MSRB2 IL11 SIGNALING%WIKIPATHWAYS_20260610%WP2332%HOMO SAPIENS IL11 signaling PDPK1 YES1 ATF1 RPS6KA1 IL11RA CREB1 MAP2K1 MAP2K2 PIK3R2 ITGA2 PIK3R1 BIRC5 MAPK1 IL11 MAPK3 RPS6 RAF1 STAT1 STAT3 IKBKB FES PTPN11 IL6ST CHUK BCL2 RELA TYK2 GRB2 IBSP TGFB1 PTPA PIAS1 SOCS3 SRC FYN HRAS RUNX2 JAK1 BGLAP RPS6KB1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260610%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit SPN CD3G CD27 CD3E CD80 CD3D BCL2 IL2 LUPUS THERAPIES%WIKIPATHWAYS_20260610%WP5560%HOMO SAPIENS Lupus therapies IL6 C4A CD22 C1QA CD40 CD80 IL23A C4B_2 C1QB CD40LG TNLG7A IL6R CD19 IL25 IL12B IL12A IL17F IL17D IL17C HEL-S-62p IL17B IL17A MS4A1 C1QC IFNG EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260610%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PIK3CA SOS1 AXL MAPK1 MAPK3 EGFR BAD ARAF STAT3 AKT3 RRAS MTOR BAX IL6R SOS2 BCL2L11 PIK3CD PDGFRA RPS6KB2 SRC FGF2 EIF4E SHC4 IGF1R VEGFA KDR BCL2L1 RPS6KB1 PRKCB PLCG1 PDGFD FGFR2 PDPK1 PDGFC PRKCA IL6 ERBB3 CCND1 ERBB2 EGF PLCG2 MYC MAP2K1 NF1 GSK3B MAP2K2 SHC2 TGFA SHC3 PIK3R3 SHC1 PIK3R2 IGF1 HGF RRAS2 NRG2 PIK3R1 NRAS FOXO3A RPS6 RAF1 NRG1 EIF4EBP1 FGFR3 PDGFA BCL2 GRB2 PTEN HRAS JAK1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260610%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ELOVL5 FADS1 ELOVL2 ACE2 FADS2 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260610%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1B1 HMOX1 GUCY1A2 TMPRSS2 NQO1 GCLM KEAP1 IL6 GCLC SLC7A11 IL1B MMP3 RXRA NFE2L2 NFKB1 CXCL8 TNF IKBKB IKBKG CHUK ACE2 IRF3 IL12A RELA NFKBIA CCL2 SPINA BIFIDA%WIKIPATHWAYS_20260610%WP5150%HOMO SAPIENS Spina bifida SHMT1 MTHFD1 MTR AHCYL2 MTRR DNMT3B MAT1A DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260610%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades CLU C3AR1 CR1 PLAT F3 CD46 CFH C1QA CFI C5AR1 THBD SERPIND1 APOA2 CR2 HEL-S-62p SERPINA1 SERPINF2 PLAUR F5 F8 F9 CPB2 SERPINC1 TFPI LMAN1 F10 PROC F7 PLG HEL-S-78p VWF C4B_2 C1QB CFD C1S F13B C6 CLTC C8G C7 F2R C9 MASP2 MASP1 F2 CFB CD55 KNG1 C1QC BDKRB1 SERPING1 KLKB1 PROS1 DRAVET SYNDROME%WIKIPATHWAYS_20260610%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A PRR5 STXBP1 PIK3CA PRKCA MAPKAP1 SCN1A KCNA2 PCDH19 SCN3A NFKB1 RICTOR SCN1B MLST8 SCN2B TNF MTOR SCN3B SCN8A FGF13 SCN2A SCN4B CALM1 SNTA1 HCN1 CHD2 MAPK11 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260610%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN2B GRIN3B GRIN3A NRXN1 DLG4 GRIN1 GRIA2 NLGN3 NLGN2 GRIA3 NLGN1 GRIA4 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM CYP1A2 PCK1 JUN ACOX1 CYP1A1 CYP1B1 PDK4 SP1 NR1C1 STAT3 NR0B2 PURINE METABOLISM%WIKIPATHWAYS_20260610%WP4792%HOMO SAPIENS Purine metabolism AMPD1 APRT DGUOK PNP IMPDH1 XDH ADSS ADA ADSL HEL-S-70p NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260610%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis AIFM1 DIABLO BAX PRF1 BCL2 CASP6 CYCS BAK1 HTRA2 CASP9 CASP8 APAF1 CASP3 TNFSF6 FADD IL4 SIGNALING%WIKIPATHWAYS_20260610%WP395%HOMO SAPIENS IL4 signaling PTPN6 PIK3CA SOS1 INPP5D FLNA SHC1 PIK3R2 PIK3R1 CEBPB MAPK1 NFKB1 MAPK3 ATF2 SOCS5 BAD STAT1 IL2RG STAT3 IKBKB FES PTPN11 MAPK14 CHUK EP300 CEBPA IRS1 PIK3CD RELA TYK2 IL4 NFKBIA GRB2 GAB2 STAT5B CBL SOCS3 SOCS1 JAK3 MAPK11 JAK1 FOS RPS6KB1 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260610%WP3878%HOMO SAPIENS ATM signaling in development and disease KAT5 PPP5C RNF168 CHEK2 CHEK1 STK11 TSC2 NFKB1 ATF2 TRIM28 NBN HMGN1 MDC1 RIF1 NHEJ1 RNF20 SMC1A PRKDC ATMIN CEP63 AURKB MRE11A PPP2CA MAPK14 IKBKG MTOR RAD50 RNF8 PPM1D CDK2 LMNB2 RBBP8 TP53BP1 CDK5 ATM ATR HEL-S-102 MAPK12 MAPK13 MAPK11 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260610%WP5172%HOMO SAPIENS Iron metabolism disorders PANK2 TF TFRC STEAP3 HFE TFR2 FTH1 SLC40A1 UQCRFS1 CP HAMP SLC11A2 FTL CYBRD1 HEPH VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260610%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression GRIN2B CHRM1 NR1i1 GCLC SLC8A1 ATP2B1 CYP27A1 ATP2B3 ITPR2 RXRA ATP2B2 NFE2L2 CYP27B1 TPH2 TPH1 CACNA1C KDM3A KDM1B CALB1 ATP2B4 PVALB KCNQ2 KCNQ3 KDM1A BCL2 KDM6B GRIN1 HEL-75 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260610%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups SRM OTC SMS ASL NAGS ALDH18A1 HEL-S-5 ASS1 GLUD1 ARG2 ARG1 HEL-S-20 HEL-S-29 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260610%WP1604%HOMO SAPIENS Codeine and morphine metabolism SLCO1B1 UGT2B4 UGT1A3 UGT1A1 UGT2B7 UGT1A9 UGT1A8 ABCC3 CYP3A4 ABCC2 ABCB1 UGT1A10 COCAINE METABOLISM%WIKIPATHWAYS_20260610%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260610%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling YES1 RELB MAP2K1 MAP2K2 MAPK8 LYN MAPK1 NFKB1 NFKB2 MAPK3 RPS6 STAT1 STAT3 FES EIF4EBP1 PTPN11 MAPK14 IL7R BTK TEC CRLF2 RELA MAPK9 NFKBIA GAB2 STAT5B LCK STAT4 SRC FYN JAK1 TSLP KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260610%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 BDKRB2 BDKRB1 SERPING1 KLKB1 CPN1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP23%HOMO SAPIENS B cell receptor signaling CAMK2A RAPGEF1 SOS1 CRK INPP5D CDC42 CREB1 CD79B MAPK8 HCLS1 MAPK1 CD79A IKBKB PTPN11 MAPK14 IKBKG CHUK GTF2I LAT2 RELA GAB2 VAV1 CR2 LCK CBL BCL6 FYN BLK MAP2K6 RASGRP3 PTPRC PRKCB PLCG1 REL NFATC3 PTPN6 PIK3AP1 CARD11 NFATC2 PDPK1 RPS6KA1 PIP5K1C BCL10 CRKL PLCG2 MYC MAP2K1 GSK3B CD81 MAP2K2 SHC1 PIK3R2 CD22 NCK1 PIK3R1 FOXO1 LYN NFKB1 ATF2 RAF1 GSK3A STM7 PIP5K1A JUN BTK CD19 TEC DAPP1 BASH PTPN18 MAPK9 NFKBIA GRB2 MAPK4 MAP3K7 SYK HRAS MAP4K1 RAC1 VAV2 MAX 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome DYNLT2B DYNC2LI1 DNCL1 RNF8 STAT5B ADAM10 SIRT1 HIF1A DYNLRB2 RNF168 MYC HFE PIK3R3 DYNLT1 PXN MCRS1 H2BC21 DYNLT3 DYNLL2 JUN TF CEP19 TFRC NRROS SLC40A1 PIGX UBXN7 TGFB1 SMCO1 DYNC2H1 NCBP1 HAMP NCBP2 RABL2B FBXW7 FNDC8 HEL-S-71 PIGM MFI2 NF2 MYCBP2 FBXO45 SLC51A ZDHHC19 SLC51B BRINP1 DYNC2I2 TM4SF19 CEP350 MAD2L1BP WDR53 ZNF76 ROTENONE METABOLISM%WIKIPATHWAYS_20260610%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP5094%HOMO SAPIENS Orexin receptor pathway NPVF HCRT OPRK1 HCRTR2 HCRTR1 BMPR1A CREB1 LHB GNAS IL1B TH PRKAA1 MAPK8 GNRH1 MAPK1 CXCL8 MAPK3 DAGLA DKFZp686L0365 CXCL2 GH1 TNF STAT3 CCK GNAI1 PTPN11 STAR MAPK14 MTOR IL10 PRKD1 VHL SMAD1 IL9 SLC1A2 RUNX2 HIF1A EIF4B RPS6KB1 PRKCB PDPK1 PRKCA RPS6KA1 PRKCZ IL6 POMC DKFZp781O1323 MAP2K1 MAP2K2 PIK3R2 PIK3R1 GCG NFE2L2 FOXO1 CAMKK2 NOX4 SLC2A4 LEP RPS6 DYNLT1 NPY DYNLT3 EIF4EBP1 GHRL PRKCE GNA11 MAPK9 MAPK7 IL4 BMP7 SGK1 CASP9 FSHB CASP3 CGA BGLAP NPFFR1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260610%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway TUBA3E TUBA1C PSMD7 TUBB6 TUBA1B TUBA1A PSMD9 TUBB1 PSMD6 TUBB PSMD4 PSMD5 RNF19A PSMD3 TUBB4B PSMD1 TUBB4A CASK TUBA4A TUBA4B TUBB2A PSMD10 SNCA PARK2 PSMD11 HSPA14 TUBA2 PSMC1 PSMD12 TUBA8 PSMD13 PSMC6 SEPT5 PSMC4 UBE2L6 UBE2J2 UBE2L3 GPR37 UBE2G1 UBE2G2 PSMD2 SIAH2 HSPA2 HEL-S-72p CCNE1 HSPA1A HSPA4 FBXW7 SNCAIP CASP8 STUB1 HEL-S-89n HEL-S-91n TUBAL3 TUBB8 UBE2J1 SIAH1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260610%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells HEL-S-304 RPE PRPS1L1 DERA RPIA INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260610%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAP2K4 MAPK10 MYD88 MAP3K8 MYC RPS6KA5 MAP2K1 MAPKAPK2 MAP2K2 MAPK8 TAB3 NFKBIB MAPK1 SAFB NFKB1 MAPK3 MAP3K14 ATF2 IKBKB IRAK2 MAP3K7IP1 MBP MAPK14 CHUK IRAK4 MAP2K3 RELA MAPK9 NFKBIA TRAF6 IRF7 MAP3K7 IL1R1 TANK MAPK11 EIF4E IL1A IRAK1 MAP2K6 MAP3K1 FOS TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260610%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SIN3A HDAC3 LATS2 SKI TEAD2 SKIL TEAD3 TEAD4 LATS1 HDAC1 NF1 MERTK FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260610%WP143%HOMO SAPIENS Fatty acid beta oxidation LPL CPT1A ECHS1 CRAT GPD2 ACSS2 ACSL1 ACSL6 FACL4 ACSL5 ACSL3 LIPF LIPE LIPC CHKB ACADVL PNPLA2 CPT2 ACADL SLC25A20 ACADS DLD ACADM GCDH ACAT1 HADHB DECR1 HEL-S-49 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260610%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AC6 TERF2IP H2BC12 H2AX TERF1 H2AZ1 H2AC19 H2AZ2 ACD TPP1 H2AB1 H2AC14 H2BC26 H2BC12L H2AJ H2BC21 HIST1H2AB H2BC17 H2BC13 H2BC14 H2BC15 H2BC11 HIST1H2BE H4C9 H2BC9 H2BC8 H2BC3 H2BC1 HIST1H4L H2AC20 H3-4 TERF2 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260610%WP4504%HOMO SAPIENS Cysteine and methionine catabolism ETHE1 SUOX CDO1 pcap CTH MTR HEL-S-64p GCLC CBS HEL-S-61p SQOR MAT1A MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids MTOR PIK3CA TSC1 S1PR1 NFKB1 S1PR3 ASAH2 HIF1A SPHK2 CERK IGF1R LASS1 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260610%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection UBB CBFB CUL5 RUNX1 RBX1 ELOC APOBEC3G HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260610%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease LTBP2 NR2C2 MAPK14 LTBP1 SMAD2 ENG TGFBR2 FLNA POSTN CTGF SHC1 MAPK8 AGTR1 MAPK1 TGFBR1 MAPK3 SMAD4 ANGPT2 FBN1 RUNX2 FBN2 FBN3 TGFBR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260610%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts XYLT1 CSGALNACT1 B3GAT3 XYLT2 CHST11 B3GALT6 CHSY1 CHST14 CHST3 HS3ST3A1 CHPF HS6ST1 HS6ST2 HS2ST1 HS6ST3 EXTL2 EXTL1 CHST12 NDST3 EXT1 CHSY3 CHST13 EXT2 HS3ST3B1 CHST7 CHPF2 B3GAT2 GLCE B3GAT1 CSGALNACT2 CHST1 HS3ST1 HS3ST2 UST LUPUS PATHOGENESIS%WIKIPATHWAYS_20260610%WP5559%HOMO SAPIENS Lupus pathogenesis CD40LG TNLG7A IL6 TLR9 TNFRSF13C BCR IFNA2 TLR7 PDCD1 TLR4 IL17A ICOS CD40 CD80 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260610%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH4 NOTCH2 SP7 NOTCH1 SOST KLF4 HNF1A DMP1 BMP7 DKK1 DSPP RUNX2 ALPL NOTCH3 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP560%HOMO SAPIENS TGF beta receptor signaling TGFBR2 NOG SMAD6 SKI SKIL MAPK3 FOXH1 STAT1 TNF STAT3 LTBP1 ENG EP300 LEF1 LEFTY1 SMAD1 CREBBP FKBP1A SMAD4 ZFYVE9 RUNX2 TGIF1 BAMBI INHBA LEFTY2 THBS1 SMAD9 EGF DKFZp781O1323 ZNF423 opn RUNX3 TGFBR1 NFKB1 ITGB6 SMAD2 JUN ZEB2 MAPK9 TGFB1 FST BMP4 HRAS JAK1 IFNG WNT1 LIF FOS TGFBR3 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260610%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 GPD1 HEL-S-133P PPARG HIF1A CD36 HEL-S-162eP HEL-S-49 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260610%WP1434%HOMO SAPIENS Osteopontin signaling CHUK MAPK1 opn NFKB1 ITGB3 MAP3K14 MAPK3 ITGAV MAP2K1 MMP9 RELA IKBKB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL-21 DHODH ITGB7 EGFR IFNG F2RL1 TNF IL2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260610%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 STAT2 IKBKE MAVS RIGI MAPK8 NFKB1 STAT1 IKBKB TBK1 MAPK14 IKBKG JUN CHUK IFNAR2 TICAM1 EIF2AK2 IRF3 IFIH1 TRAF3 TYK2 NFKBIA TRAF6 TLR7 OAS1 MAP3K7 IFNAR1 IRF9 OAS2 JAK1 RIPK1 OAS3 FOS SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260610%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins NCDN GRIN2B STX2 KCNJ6 NTNG1 TERF2IP CADM3 CADM1 PLCB4 SNW1 KCNMA1 PRKCZ DAB1 CSN3 AGRN CASK GRIK2 ATP2B1 GABBR2 EFNA5 CAMK2G GPHN MAP4 KCNQ2 CAV2 CDH2 MAPK9 MAPK4 GRIN1 RAP1GAP CLASP1 CHL1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment IFITM2 BAG3 CSF1R CXCL12 CSF2RA TGFB1 CCR5 HLA-DRB1 CSF2 CSF1 CXCR4 CCR2 CCL5 ITGB6 NRP1 CD80 TNFSF6 CCL2 CXCR3 VEGFA CTLA4 KDR IL5 SIGNALING%WIKIPATHWAYS_20260610%WP127%HOMO SAPIENS IL5 signaling RPS6KA1 SOS1 SPRED1 CSF2RB MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 PIK3R1 LYN MAPK1 MAPK3 FOXO3A RPS6 RAF1 GSK3A STAT1 IL5RA STAT3 PTPN11 JUN BTK IL2 GRB2 STAT5B SYK RPS6KB2 JAK1 RPS6KB1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260610%WP45%HOMO SAPIENS G1 to S cell cycle control CDK7 CDKN2D POLE CDKN1C CREB1 WEE1 E2F3 CDKN2B PRIM2 PRIM1 CDKN2A CREB3 ATF6B POLA2 POLE2 CCNH MCM7 ORC1L RB1 CCND1 MYT1 MYC TFDP1 CDKN2C TFDP2 MNAT1 PCNA CDC45 CCNG2 CCND3 E2F2 CCND2 RPA1 RPA3 CREB3L3 CCNE2 CREB3L4 CCNE1 CCNB1 CDC2 MCM3 GADD45A CDK4 MCM5 CDK2 MCM6 CDK6 MDM2 ATM CDKN1A CDKN1B MCM2 ORC6 ORC3 ORC2 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260610%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease MYOG DES DMPK HEL25 HP1BP3 HSPB2 HSPB3 MYOD1 LBR LMNA H2AZ1 MEF2C ACTA1 NOTCH3 TP53 NETWORK%WIKIPATHWAYS_20260610%WP1742%HOMO SAPIENS TP53 network BOK PMAIP1 BAX GADD45A MYC BCL2 MDM2 ATM BBC3 TP73 CDKN1A TNFSF10 OTX2 TP63 SUMO1 CDKN2A WNT SIGNALING%WIKIPATHWAYS_20260610%WP428%HOMO SAPIENS Wnt signaling CAMK2A PLCB3 PLCB4 PLCB1 PLCB2 CSNK1A1 INVS CAMK2D APC PPP3CC WNT3A NLK FOSL1 PPP3R2 CSNK2A1 PPP3R1 CCND1 MYC CTNNBIP1 DAAM1 NFATC4 DAAM2 PRICKLE2 GPC4 CCND3 CCND2 FZD7 AXIN1 FZD8 SFRP4 DVL2 JUN MAPK9 FRAT2 SOX17 LRP5 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 FZD1 CSNK2B RAC1 KREMEN1 WIF1 ARHA MAPK8 RYK NOTUM CTBP2 ROR1 ROR2 DVL3 PORCN CHD8 SOST SENP2 LEF1 VANGL1 CXXC4 TCF7L2 TCF7L1 hCG_2014051 PRKCB NFATC3 NFATC2 NFATC1 PRKCA PPP3CA GSK3B WNT2B FZD10 WNT5B WNT16 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A CAMK2G ROCK2 FRAT1 CTBP1 NKD1 NKD2 MAP3K7 DVL1 WNT1 FZD2 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260610%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects TUBA3E MAPK10 TUBA1C TUBB6 TUBA1B TUBA1A PLCB3 PSMD9 PLCB4 TUBB1 PSMD6 TUBB PSMD4 PSMD3 TUBB4B KIF5A PSMD1 PLCB1 TUBB4A PLCB2 TUBA4A TUBB2A SNCA PSMC1 TUBA2 TUBA8 ERN1 TNF PPP3CC TRAF2 VDAC3 ATP2A1 XBP1 DDIT3 CACNA1F APH1B FADD PPP3R2 IRS4 CACNA1S PPP3R1 PSENEN IL6 BACE1 APP MAP3K5 PSEN2 PSEN1 LPL NRBF2 ATG2B MME PSMA2 KNS2 PSMA8 PSMB6 PSMB2 PSMB3 HEL-S-276 RTN3 GPR83 KLC4 KLC3 ADAM17 KLC2 NAE1 BECN2 HEL-S-61 AMBRA1 ADRM1 ATF4 SLC25A31 EIF2AK2 INS EIF2S1 MAPK9 FRAT2 CALM1 CSNK2A3 CSNK2A2 DKK1 DKK2 DKK4 CSNK2B PSMD7 IL1B PSMD12 PSMD13 DVL3 CALML6 CALML3 CALML4 MCU CSNK1A1L PPP3CA CYBB GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 ITPR2 NRAS WNT16 RB1CC1 WNT3 WNT4 ULK1 WNT10B WNT10A PPIF FZD3 FZD5 CACNA1C WNT7B FZD9 WNT7A RTN4 FRAT1 SLC25A5 HEL-S-91n DVL1 ATP2A2 FZD2 AXIN2 CSNK1A1 CSF1 PSMC6 APC PSMC4 AGER IRS1 PIK3CD HEL-S-162eP WNT3A SHFM1 HSD17B10 PSMD2 GRIN2B CSNK2A1 PIK3R4 WIPI1 MAP2K1 ULK2 MAP2K2 FZD7 AXIN1 FZD8 SFRP4 RAF1 APAF1 DVL2 CDK5R1 CDK5 CYCS LRP5 GRIN1 CASP9 LRP6 CASP8 CASP3 HRAS FZD1 CASP12 PIK3CA ATG101 WIPI2 ATG14 MAPK8 MAPK1 ATG2A MAPK3 BAD ARAF RYR3 IKBKB AKT3 MTOR CHUK RELA SLC25A6 hCG_2014051 ADAM10 APOE APC2 INSR NFKB1 NOX4 CHRNA7 PSMA4 NOS2 IL1A PTGS2 TUBAL3 WNT1 TUBB8 TNFRSF1A SLC25A4 AMINO ACID METABOLISM%WIKIPATHWAYS_20260610%WP3925%HOMO SAPIENS Amino acid metabolism OTC CAD DDC HDC CBS DBH TH OGDH SUCLG1 HEL-S-53e ADH5 MARS2 ACLY G6PC2 PC HMGCL ACSS1 ARG2 PNMT PIG59 HEL-S-61p TPO EHHADH MAOA FTCD ASNS FH EPRS1 HEL-S-30 HEL-75 GLS PDHA1 MDH2 CTH GOT2 HEL-S-26 HEL-S-133P GCLM TDO2 ASS1 GLUD1 ACO2 RARS1 PCK1 PDK4 HEL-S-64p ADH7 TPH1 BCAT1 HEL-S-4 GPT2 MCCC1 SRM LARS2 SMS ADH1C ALDH18A1 PPM1L VARS1 HAL IARS FARSB ARG1 SDHA P4HA2 ALDH7A1 DLD ACADM PDHX CS HEL-S-32 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260610%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis STAR AKR1C2 SRD5A2 AKR1C4 HSD3B2 POR HSD17B3 HSD17B6 CYP17A1 CYP11A1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260610%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms MAPK10 LIMD1 TEAD2 TEAD3 TEAD4 ITGB1 CTNNA1 YWHAQ MAPK8 PAK1 ITGB4 ITGB7 ITGB8 ITGB6 HEL-S-31 ACTG2 WWTR1 MAP4K2 ACTA2 LATS1 PAK6 ACTG1 MAPK9 PAK4 SGMS1 PS1TP5BP1 MAP4K3 NF2 YAP1 ITGB3 SRC ACTA1 MAP4K1 ERBB SIGNALING%WIKIPATHWAYS_20260610%WP673%HOMO SAPIENS ErbB signaling CAMK2A MAPK10 PIK3CA HBEGF ERBB4 SOS1 CRK MAPK8 PAK1 MAPK1 CAMK2D MAPK3 EGFR BAD ARAF AKT3 MTOR SOS2 BCL2L11 PIK3CD NRG3 STAT5B CBL RPS6KB2 SRC SHC4 RPS6KB1 MAP2K4 PRKCB PDPK1 PRKCA CRKL ERBB3 CCND1 ERBB2 EGF PLCG2 MYC MAP2K1 GSK3B MAP2K2 SHC2 TGFA EREG SHC3 PIK3R3 BTC SHC1 PIK3R2 NCK2 NCK1 NRG2 PIK3R1 FOXO1 NRAS RAF1 NRG1 EIF4EBP1 AREG CAMK2G JUN PAK6 MAPK9 PAK4 MDM2 NRG4 GRB2 ABL2 CDKN1A CDKN1B HRAS OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260610%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CXCL6 CXCL9 IL1RN CSF2 CSF1 CXCL8 IL36A CXCL17 IL36B CTF1 CXCL1 CXCL13 CXCL3 IL23A CXCL2 TNF CXCL5 IL10 IL36RN IL37 IL36G IL2 IL1F10 IL9 CCL5 CCL4 CCL3 CCL2 IFNB1 PPBP IL6 CXCL11 CXCL12 PF4 MMP3 IFNA5 IFNA4 IL4 IFNA7 CNTF IFNA6 CCL3L3 IFNA1 IFNA2 CCL17 IFNA8 CCL16 IL18 TSLP IFNG OSM LIF CSF3 EPO IL22 IL20 IFNA13 IL26 IFNA14 IL24 IFNA16 IL27 IFNA17 IL1B CX3CL1 IFNA10 PF4V1 IL11 IFNA21 IL19 CCL14 CCL13 IL7 CCL11 TNFSF13 TNLG7A CCL19 CCL18 CCL15 CCL25 IL33 CCL24 CCL23 IL31 CCL22 CCL21 IL3 CCL27 CCL26 MMP9 CCL4L2 VEGFA CXCL14 IL-21 CXCL16 EBI3 IFNW1 opn NFKB1 IFNK LTA XCL2 XCL1 IL5 AREG IFNL2 CCL8 IFNL1 CCL7 IL25 CCL1 IL12B IFNL3 IL12A CCL20 TGFB1 IL13 IL17F IL17D IL17C CCL28 IL17B IL17A IL1A KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260610%WP4236%HOMO SAPIENS Krebs cycle disorders SUCLA2 SUCLG1 PDHX HEL-S-133P DHTKD1 FH MPC1 GPT PCK2 SUCLG2 HEL-S-281 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260610%WP3601%HOMO SAPIENS Lipid particles composition LPL APOC2 APOB APOE LDLR APOA2 APOC3 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260610%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP46A1 CHST14 CHST3 GPX2 CYP21A2 GPX3 CYP11A1 GSTT2 CYP51A1 HS3ST3A1 HS6ST1 HS6ST2 HEL-S-166mP HS2ST1 HS6ST3 CHST12 NDST3 CHST13 HS3ST3B1 CHST7 SULT1E1 HS3ST1 HS3ST2 AKR1D1 EPHX2 BAAT CYP8B1 UGT1A10 GSTM2 MGST3 HEL-S-64p MGST2 UGT2B11 UGT2B15 UGT2B17 UGT2B28 HEL-S-75p UGT1A5 UGT2B4 GSTM5 CYP26B1 UGT2A2 UGT2A1 UGT2B7 SULT2B1 CYP26A1 MGST1 CYP7A1 GSTZ1 HEL-S-21 HEL-S-75 Em:AP000351.3 GSTA5 CHST10 CYP4F2 GSTA4 NAA50 GSTA3 CYP2C18 GATF-C GLYATL2 GPX4 AKR1B10 GSTM1 NAT8 NAT2 CYP2A13 NAT9 NAA40 NAT10 NAT14 AKR1B1 LOC51064 GAL3ST2 GAL3ST3 GAL3ST4 CHST8 CHST9 UGT1A1 KCNAB1 KCNAB3 GSTM4 CHST4 NAT8L CHST5 NAA20 HS3ST5 HS3ST6 CYP2C19 FMO4 CYP4F12 CYP17A1 HS3ST4 CYP2C9 FMO5 CYP27A1 CYP2R1 CYP2A6 CYP2B6 CYP3A43 SULT2A1 HYAL3 CYP26C1 UGT1A4 UGT1A3 UGT1A9 CHST6 UGT1A7 NNMT INMT SULT1A1 CHST1 CYP4F3 HEL-75 SULT1C3 SULT1B1 SULT1C2 SULT6B1 SULT1A4 SULT1A2 CYP1A2 SULT1C4 HEL-S-165mP AKR1C1 EPHX1 CYP1A1 CYP1B1 AKR1C2 AKR1C4 CYP3A4 CYP2E1 CHST11 CYP27B1 CYP24A1 CYP11B2 TPMT GSTM3 CYP2S1 HEL-S-22 CYP4Z1 CYP3A7 CYP4V2 CYP7B1 CYP2A7 CYP2U1 CYP4F22 CYP4X1 CYP2F1 CYP2J2 CYP4F11 CYP4F8 CYP2W1 CYP27C1 CYP20A1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260610%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway PTPN11 IL6ST PDGFD TGFBR2 ACTA2 IL11RA SP1 ACE2 COL1A1 COL1A2 TGFB1 CTGF AGTR1 MAPK1 TGFBR1 IL11 NOX4 JUND SMAD4 RAF1 HIF1A MAP2K6 MAS1 RRAS COMPLEMENT SYSTEM%WIKIPATHWAYS_20260610%WP2806%HOMO SAPIENS Complement system C4BPA ELANE C3AR1 CR1 TXN SELL CD46 CSNK1A1 F13A1 SELPLG CPN1 FCGR3A VSIG4 ITGA2 CD93 CFH HEL-S-92n C5AR2 FCER2 CFI SELE FKBP2 C5AR1 FPR1 F11 RPS19 CFHR2 DKFZp686L0365 CD59 CFHR4 PTX3 SFTPA1 CRP ITGA2B IBSP GNAI3 CR2 HEL-S-99n GNA15 HEL-S-62p PLAUR WAS VTN F10 PRKCA THBS1 CLEC4M C4A ICAM2 FGA opn LAMC1 SELP PLG CD40 HEL-S-78p ALB ADM SFTPA2 LAMA5 CD19 CFD C1S CFP C8A LAMB1 C6 DCN C7 C9 MASP2 ITGB3 MASP1 C1QBP CFB CD55 FCN1 MBL2 FCN2 SERPING1 KLKB1 PROS1 PRNP CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260610%WP5601%HOMO SAPIENS Caffeine in blood vessels PDE4B PDE4A GUCY1A2 PDE4D ADRA1A ADCY3 ADRA1D ADCY1 ADRA1B MYLK PDE3A PDE3B ADCY8 ADCY6 CALM1 ADCY5 HEL-S-80p ADCY9 RYR2 ADORA2A ADORA2B RYR3 PPP1R12C PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260610%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins ATG3 RAB7A ATG12 SQSTM1 DKFZp686F0183 DEPTOR ATG16L1 TMEM59 DKFZp762B153 VPS39 ATG9A VPS41 ATG2B VPS18 AKT1S1 RB1CC1 GABARAPL2 LAMTOR1 VPS33A MLST8 RPS6 ULK1 OPTN PPP1R9A VAMP8 MTOR APOB VPS16 RHEB PRKAA2 NBR1 LAMP2 RPTOR LARP1 CALCOCO2 HEL-S-30 EIF4B RPS6KB1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260610%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CRP CCL11 CHI3L1 PBR IL6 NEFL CCL23 IL1B CX3CL1 GFAP DBI CCL5 OLR1 BDNF TREM1 CCL2 ADM TNF GRN S100B CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260610%WP530%HOMO SAPIENS Cytokines and inflammatory response IFNB1 IL5 IL7 CSF3 PDGFA IL6 IL10 IL12B IL2 IL4 IL1B TGFB1 IL13 HLA-DRB1 CSF2 CSF1 IL11 IL3 CXCL1 IL1A CXCL2 IFNG TNF MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260610%WP727%HOMO SAPIENS Monoamine transport and regulation TNFRSF11B TGFB1I1 TDO2 SLC6A3 DBH IL1B TH TSC2 SLC5A7 SYN1 TPH2 TNF AMPH HRH3 MAPK14 NECTIN2 SLC6A2 FBXO32 UNC13B RBL2 ACHE STX1A IL1R1 ITGB3 ADORA2A NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260610%WP5572%HOMO SAPIENS Nucleosome remodeling complex SUPT16H SSRP1 ASF1A NASP HAT1 CHAF1B ASF1B CHAF1A CHEK2 PCNA H4C9 XRCC5 MCM2 HIST1H4L RBBP4 PRKDC SMIM40 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis AKR1C1 UGT2B7 HSD11B1 HSD11B2 AKR1C2 SRD5A2 AKR1C4 CYP11B2 AKR1D1 CYP21A2 UGT1A10 PROLACTIN SIGNALING%WIKIPATHWAYS_20260610%WP2037%HOMO SAPIENS Prolactin signaling PIK3CA SOS1 HEL-S-93 AGAP2 FLNA ITGB1 PRLR MAPK8 YWHAG PAK1 MAPK1 MAPK3 STAT1 STAT3 PTPN11 MAPK14 MTOR HEL-S-69p IRS1 NEK3 RELA GAB2 VAV1 STAT5B ZAP70 CBL SOCS3 SOCS1 SRC FYN RPS6KB1 PTPN6 RPS6KA2 SIRPA ERBB2 HEL-S-130P MYC MAP2K1 GSK3B MAP2K2 SHC1 PIK3R2 NFKBIB PIK3R1 NFKB1 RPS6 RAF1 PPIB PXN EIF4EBP1 JUN TEC MAPK9 NFKBIA GRB2 PTPN1 PRL CASP3 HRAS CISH JAK1 RAC1 VAV2 FOS SOCS2 MONOAMINE GPCRS%WIKIPATHWAYS_20260610%WP58%HOMO SAPIENS Monoamine GPCRs HTR1A CHRM1 HTR2A ADRA1A HTR4 HTR6 CHRM2 HTR7 ADRB3 DRD2 DRD1 HTR1E HTR1F HTR1D HTR1B ADRA1D ADRB1 HTR2B ADRA1B ADRB2 HRH1 HRH2 DRD5 ADRA2C HTR5A ADRA2B CHRM3 ADRA2A CHRM4 CHRM5 DRD3 DRD4 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260610%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260610%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair SUPT16H SSRP1 NASP RNF8 RNF168 RAD51 H1-1 ATM TP53BP1 H4C9 XRCC5 HIST1H4L NBN SETD2 MDC1 PRKDC NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260610%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma KREMEN1 ELAVL1 KLF4 WIF1 CSNK1A1 RYK NOTUM CTBP2 ROR1 ROR2 APC DVL3 PORCN CHD8 SOST SENP2 LEF1 WNT3A MTDH CXXC4 TCF7L2 TCF7L1 hCG_2014051 CSNK1A1L NLK FOSL1 EZH2 CSNK2A1 CCND1 MYC GSK3B CTNNBIP1 WNT2B FZD10 SOX7 WNT5B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A JUN FRAT1 CTBP1 FRAT2 NKD1 NKD2 SOX17 LRP5 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 DVL1 FZD1 CSNK2B WNT1 FZD2 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260610%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy ELANE TGFBR2 CASQ1 IL1B PRKAA1 RYR1 CAMK2D SSPN MPO TRPC1 TNF MCU IL10 ATP2A1 CTGF SLN MCUB SCX CACNB1 SGCA TRDN STIM1 PRG3 SNTB1 FKBP1A SMAD4 CACNA1F MMP9 CACNA1S IL6 MMP2 CYBB FGA ITPR2 TOMM20 opn TGFBR1 NFKB1 NOX4 TNNI1 DMD HEL-S-78p PPIF CACNG1 ORAI1 DAG1 SMAD2 NOS2 PRKAA2 CAPN3 NFKBIA TGFB1 AGTR1 SLC25A5 CACNA2D1 CASP9 IL1A TRPC6 TRPC3 PLA2G2A ZINC HOMEOSTASIS%WIKIPATHWAYS_20260610%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A1 MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC39A2 SLC39A1 SLC39A3 MT1M MT4 SLC30A10 MT3 SLC30A7 SLC30A6 SLC30A9 MT1A SLC30A8 SLC30A2 MTF1 SLC30A5 MT1F SLC30A4 MT1G VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260610%WP1533%HOMO SAPIENS Vitamin B12 metabolism MCEE CTH MTR HEL-S-51e CBLIF IL6 PLAT CUBN CBS TCN2 TCN1 IL1B SERPINA3 HEL-S-44 FGA INSR NFKB1 F7 SAA4 NFKB2 PLG HEL-S-78p ALB MPO SAA1 TNF SAA2 CRP SCARB1 APOB MTRR HBB LDLR HBA2 ABCA1 INS RELA MAT1A CCL5 APOE F2 CCL2 IFNG KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260610%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IFNB1 EIF2AK1 EIF2AK4 HAAO TDO2 AFMID IL1R2 AHR IDO2 KYNU CDKN1A FOXO1 TLR4 KMO KLF5 AADAT IFNG TNF HEL-S-90n IDO1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260610%WP1772%HOMO SAPIENS Apoptosis modulation and signaling AIFM1 MYD88 CASP2 BOK HRK BIRC7 CASP4 MAPK8 CRADD BCL2L2 BNIP3 HTRA2 TRADD MAPK3 BAD CDKN2A IKBKB MADD BAX BCL2L11 PRKD1 BCL2A1 IL1R2 TRAF3 TRAF6 SEPTIN4 BLK RIPK1 FADD BCL2L1 MCL1 DIABLO TNFRSF6B AIFM2 PTRH2 BAG3 BMF PTPN13 MAP3K5 TNFRSF10C TNFRSF10A BBC3 BIK PIDD1 BIRC5 NFKB1 NAIP MAP3K14 APAF1 TNFRSF1B TNFRSF25 BIRC2 BIRC3 JUN PMAIP1 BCL2L10 TNFRSF10B BCL2 CASP6 NFKBIA CASP10 BAK1 CYCS TNFSF10 IL1R1 DFFB CASP9 DFFA CASP8 CASP3 IRAK1 TNFSF6 TNFRSF10D SMIM40 FOS TNFRSF1A MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260610%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260610%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment IL2RA IL2RB TGFBR2 IRAK4 TLR8 IL4 TRAF6 TGFB1 TLR7 PDCD1 TLR4 NFKB1 NFKB2 SOCS1 CCL5 CD80 CCL2 STAT3 IL2RG CTLA4 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260610%WP170%HOMO SAPIENS Nuclear receptors RARB NR1i1 NR3C1 NR1I3 NR2E1 RORA NR0B1 NR1i2 NR2F2 NR5A2 NR2F6 RXRA NR1H2 NR3A2 NR1D2 NR5A1 PPARG ROR1 THRA NR1C2 PGR NR2C2 RXRB RXRG ESRRA NR1A2 NR2F1 ESRRB HNF4A NR1H3 NR1B3 NR1C1 RORC RARA EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260610%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DGCR8 DROSHA DICER1 AGO2 ERI1 XPO5 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260610%WP4758%HOMO SAPIENS Nephrotic syndrome ALG1 HEL-S-47e CUBN PTPRO GPC5 COL4A3 APOL1 COL4A5 ITGB4 SYNPO YARS ARHGAP24 CD2AP INF2 E2F3 WDR73 NPHS1 LMX1B NPHS2 CYP11B2 WT1 COQ8B SMARCAL1 CD151 EMP2 CTLA4 PLCE1 COQ2 MYO1E ACTN4 MYH9 COQ6 ZMPSTE24 LAMB2 LMNA PAX2 COL4A4 SCARB2 TRPC6 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5366%HOMO SAPIENS NF1 copy number variation syndrome SOS1 TUBB SUPT5H ARHA MAPK1 MAPK3 EGFR ARF6 SDC2 CCNA2 H3C15 H3C8 H4C9 USP1 JARID2 EED HIST1H4L LIMK1 NGF HOXA1 PER1 MAP3K1 EZH1 MCL1 IFNB1 RFC2 CRY1 MAVS RFC3 RFC4 EGF MYT1 HEL-S-15 RIGI NF1 OMG PCNA RTN4R SYN1 RBBP7 RAF1 WDR48 EXOC8 HOXA9 EVL CCNE2 INPP5A E2F6 RAB11FIP4 CCNE1 TEFM UTP6 ATAD5 COPRS EXOC7 RAB11A EVI2A ROCK2 CENTA2 CRLF3 SUZ12 EVI2B EXOC4 EIF3A EXOC3 METAP2 EXOC6 BCL2 EXOC5 RAD51 EXOC2 ATR POLRMT MAP3K2 RAD9A EXOC1 NGFR OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260610%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol EPHX2 AKR1C4 CYP3A4 CYP46A1 BAAT CYP8B1 NR1i2 DHCR7 SLC27A5 LBP CYP27A1 NR1H2 NR3A2 SULT2A1 INSIG1 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 SLC27A2 EBP CYP7B1 SULT2B1 AMACR DBP THEM5 ACOT6 IL25 CYP7A1 HSD3B7 ACOT4 CH25H GPR183 IL17F IL17D IL17C IL17B IL17A HSD11B1 HSD11B2 AKR1D1 RORC VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260610%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F10 PROC UBIAD1 NQO1 F7 AIFM2 F2 F9 VKORC1 GGCX PROS1 PROZ RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260610%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TBP MED25 MED24 MED21 GTF2A1 TAF9 MED15 GTF2E2 MED30 NELFA MED31 NELFE POLR2M TAF12 TAF10 TAF11 TRFP TAF7 TAF6 CRSP9 TAF4 IXL TAF3 TAF1 MED9 CTDP1 NELFCD POLR2A POLR2B CDK8 POLR2C POLR2D POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2F MED1 CCNC MED14 TAF5 THRA NELFB GTF2B MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 MED23 GTF2F1 TAF13 MED26 TAF8 MED27 MED6 MED28 MED22 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260610%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260610%WP5598%HOMO SAPIENS Sodium channel in epilepsy CAMK2A BACE1 PSEN1 GSK3B SCN1A NEDD4 PTPRN SCN11A SCN3A WEE1 PDCD10 SCN1B SCN9A SCN2B SCN7A SCN10A SCNM1 SCN4A RNF121 TNF FGF14 PRRT2 SCN3B SCN8A FGF13 SCN2A SCN4B FGF12 MAPK8IP2 CALM1 SCN5A FYN VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260610%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling HEL-S-87p TUBA1C PLCB3 EGR1 FHL2 PSMD4 MYL2 TXN CREB1 RPS6KA5 MAPKAPK2 ITGB1 PSMD11 SELE CXCL8 DKFZp686L0365 SET TPP1 ERN1 GPX1 ENG FUT1 SARS1 PRKD1 hEMMPRIN ATP6V1E1 RAB4A HEL-S-99n MAPKAPK5 DNAJB9 PRKD2 CCL2 FADD BCL2L1 OCRL EZR ITCH MAP3K5 NRP2 EIF4G1 SHC2 SHC1 MMP10 VPS39 MMP14 CAMKK2 MEF2C ATF2 RPS6 ATF4 EPHA2 MYH9 PRKAA2 FARSB MAPK9 NFKBIA RAB5A CLTC PTPN1 CACNA2D1 MAPK12 IGFBP7 ITGB3 DKK1 ITGAV RAC1 VAV2 TEAD4 CDC42 MOV10 FLNB CTNNA1 ARHA ARF4 BRD4 IQGAP1 GPC1 HEL114 PTMA ACKR3 EPRS1 DECR1 PRKCB SIAH2 PPP3CA SLC25A11 DUSP5 CYBB TNFRSF10C GSK3B MAPKAP1 PABPC1 PIK3R2 FOXO4 PIK3R1 FOXO1 tal-1 BMP10 GRB10 MLST8 FOXO3A HBD NCL ACOT9 TNFRSF25 ROCK1 ROCK2 HEL164 CTNND1 TBCA P4HA2 XB TRAF3IP2 PRKG1 HDAC7 HDAC1 CSK WASF1 CYR61 RCAN1 RPL5 FXR2 HEL2 DLL4 ELOC RPL13a CALU RPL10A RPL7 PRKAA1 NAPA RPL18A RPLP2 LUC7L UBAP2L CHAC1 RPS11 ARF6 IER5 ACACB TMEM170A ACACA ABCF2 SND1 PLA2G5 KATNAL2 EWSR1 BIN1 ATP6V0D1 GIGYF2 HMGB1 DHX36 MYO6 MICAL2 PRRC2C LARP7 MAP2K3 HEL-S-162eP SRPK1 RPL27 DHX29 RPL26 KCNC3 CTGF CCDC124 SRP54 EEA1 ELOA CLIC1 NUMB CGNL1 CBL SSR4 SSR3 FJX1 KANK1 PLAUR FYN CRIP2 EIF4E SLC7A1 SDCBP APOLD1 MAP2K6 FGD5 COPG1 FBXW11 PLOD3 RPS6KB1 LMAN1 CCRL2 MYO1C TMSB10 PTPN6 HEL107 NCF1 SEMA6D NCF2 DOK1 ARMCX1 RAB37 HEL-S-133P FRS2 ZNF555 DSC1 HEL-S-68p CCND1 LRRC59 HTRA1 HEL-S-15 GLUD1 ZC3H15 AP2A1 HEL-S-94n MAP2K1 HEL-S-84 AFDN MAP2K2 TFCP2 NR4A3 SPIRE1 GRSF1 SHB C15orf39 NCK1 FGA HGS NRARP LDB2 RND1 CAPZB BMX LRRFIP2 ERG ADAMTS9 RAF1 ARHGEF15 HEL-S-78p SHROOM2 ALB EIF3S3 MMRN2 HEL-S-128m PXN PPM1G HLX RAP1A DNAJB4 FAM120A PPP2CA SLC25A25 PDE4DIP PRKCE JUN CDC42BPB RAB11A FMNL3 PTPN9 EIF3F SLC2A14 EIF3D BCL2 MDM2 GRB2 CYCS EPHB2 HRAS CCT7 AMOT TRPC3 INPP4B HDAC5 NOTCH4 HBEGF TAOK2 PIK3CA RAPGEF1 CRK HEL-S-2a TXNIP F3 FHOD1 MAPK8 PAK1 AKT1S1 MAPK1 PTK2B RICTOR MAPK3 STAT1 SYNJ1 TRPC1 FLII STAT3 PTPN11 MAPK14 MTOR S1PR1 GJA1 SDF2L1 TMSB4X ADRB2 HYOU1 RELA EIF2A SH2D2A CSRP2 EPN1 ADAM10 CREBBP AP2S1 FLT1 LIMK1 SRC VEGFA KDR PLCG1 MAP2K4 ADAM9 CNP PRKCI NFATC2 NFATC1 PDPK1 PRKCA DPM1 PRKCZ PFN1 SLC8A1 MMP2 KL BIRC5 NFKB1 NOX4 ANXA1 QK3 TMOD1 GATA2 TPM3 AAG1 PNP FAF1 ACTG1 HEL-S-102 TFAM BMP2 PTGS2 TUBB8 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5406%HOMO SAPIENS 13q12 12 copy number variation CDC42 ARHA RTN4R MAPK8 SSPN LINGO1 DMD TNFRSF19 TRAF1 MIPEP DAG1 SACS RTN4 C1QTNF9 ATXN1 TRAF2 SGCD SGCB SGCG MAPK9 C1QTNF9B TRAF3 SPATA13 TRAF5 SGCA SNTA1 SNTB1 RAC1 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260610%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death AMBRA1 ATG3 ATG10 CHAF1A ATG12 DKFZp686F0183 INS ATG16L1 BCL2 ULK2 VMP1 ATG14 TSC2 TSC1 SH3GLB1 INSR UVRAG ATG9B ULK1 MAP1LC3A TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260610%WP3945%HOMO SAPIENS TYROBP causal network in microglia TYROBP NPC2 SAMSN1 CYTL1 GAL3ST4 NCKAP1L ITGAX LHFPL2 GAPT MAF LYL1 DPYD HCLS1 ITGAM GPX1 SLC7A7 IL10RA HEL-S-62p CXCL16 PLEK NCF2 RPS6KA1 ZFP36L2 SH2B3 RGS1 PYCARD IL13RA1 opn RUNX3 TGFBR1 HEL-S-66 TNFRSF1B HLX CREB3L2 CENTA2 NRROS CD84 FKBP15 LOXL3 GIMAP2 TCIRG1 PPP1R18 CD37 RNASE6 IL18 LGALS9C APBB1IP BIN2 C1QC ELF4 SFT2D2 RBM47 IGSF6 KCNE3 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260610%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX SUI1 EIF3F EIF5 EIF3D EIF2S3 EIF3A EIF3S2 EIF3J EIF3G EIF2S2 EIF2S1 EIF3CL EIF3E EIF3B EIF3S3 CORI CYCLE%WIKIPATHWAYS_20260610%WP1946%HOMO SAPIENS Cori cycle HEL-S-87p SLC2A2 PGAM1 PFKP HEL-S-133P SLC2A4 HEL-S-68p GPT INS HEL-S-162eP HEL-S-49 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260610%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RASGRF1 NRAS MAPK1 HTR2A MAPK3 RAF1 HTR2B HRAS MAP2K1 MAPKAPK2 MAP2K2 GATA4 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260610%WP5133%HOMO SAPIENS Non classical role of vitamin D AGTR1 CYP2R1 AGTR2 CYP27B1 ACE2 REN QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260610%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis JUN KEAP1 COX1 NFKBIA MAFG MAFK CYP2A6 NFE2L2 NFKB1 PTGS2 VEGFA IKBKB FOS DNA REPLICATION%WIKIPATHWAYS_20260610%WP466%HOMO SAPIENS DNA replication MCM7 UBC RFC2 ORC1L MCM10 POLE CDC6 RFC3 RFC4 PCNA RPA4 CDC45 CDT1 RPA1 PRIM2 RFC1 RPA3 PRIM1 GMNN POLD3 POLD4 POLD2 MCM3 CDK2 MCM5 MCM6 POLA1 MCM2 POLA2 ORC6 POLE2 ORC3 ORC2 DBF4 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260610%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria SUV39H1 MTA2 RB1 CHD4 H3C15 CBX3 KDM1A HEL25 MTA3 LEF1 H3C8 MBD2 CBX1 H3F3B MBD3 HDAC2 RBBP7 RBBP4 HDAC1 CHD3 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260610%WP5382%HOMO SAPIENS TGFB Smad signaling YWHAG SMAD2 WWTR1 TGFBR2 TGFBR1 SPARC SMAD4 TGFBR3 POSTN CTGF WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260610%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia SALL4 AXIN2 CCND1 PML PYGO1 MYC CSNK1A1 LEF1 WIF1 GSK3B BCL9 TCF3 RUNX1T1 LRP5 JUP ZBTB16 LRP6 DKK1 FLT3 APC NR1C2 WNT1 RARA MRNA PROCESSING%WIKIPATHWAYS_20260610%WP411%HOMO SAPIENS mRNA processing SFPQ PRPF40A SNRPB2 PTBP1 POLR2A SRPK1 PRMT1 SRP54 CLK2 PRMT2 HNRNPAB YBX1 HNRNPH1 HNRNPL SMC1A PPM1G DICER1 FUS RNMT SUPT5H CD2BP2 HNRNPR CLP1 SNRPD2 PAPOLA SNRPD1 TXNL4A PSKH1 METTL3 SNRPD3 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG SRSF4 DHX15 SREK1 SNRPE SRSF6 SRSF7 SNRPF SNRPA SNRPB DHX8 DDX1 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 WDR57 SRPK2 CPSF4 SNRPN CPSF1 CPSF3 NONO CPSF2 SFRS3 DHX16 CLK4 LSM2 CLK1 LSM7 HNRNPD SRSF10 RNPS1 CLASRP HNRNPC SNRPA1 DKFZp434N041 SUGP2 SF3B5 SUGP1 SF3B2 CELF2 CELF4 RBM5 RBM17 PRPF18 NHP2L1 DNAJC8 SF3A1 CSTF2T SF3A2 U2AF1 PABPN1 U2AF2 PHF5A TRA2B SPOP NUDT21 HNRNPA2B1 RBMX SRSF9 TMED10 CELF1 NCBP1 NCBP2 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260610%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C8A C6 C7 HEL-S-62p C3AR1 C9 C5AR1 MASP2 ACE2 COLEC11 FCN1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome KAT2B GOLGA8R FAN1 ARHGAP11B KLF13 OTUD7A GPR75 GOLGA8O GOLGA8Q MTMR10 TRPM1 GOLGA8H GRM6 CHRFAM7A CREBBP CCL5 FYN CHRNA7 FANCD2 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260610%WP404%HOMO SAPIENS Nucleotide metabolism SRM IMPDH1 NME2 ADSS RRM1 RRM2 DHFR POLA1 MTHFD2 OAZ1 POLG ADSL RRM2B DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260610%WP5173%HOMO SAPIENS Disorders of galactose metabolism AKR1B1 SLC2A2 GYS2 HEL-S-19 SLC5A1 GYG1 GYS1 PYGL MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260610%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 AREG CCND1 EGF ERBB2 MYC FOSL1 PGR HEL113 TIMP1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260610%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome CAMK2A OPRK1 FOXG1 FGF3 REST FGF4 SST CREB1 SIN3A TAF1 TET2 NCOR1 MBP MTOR APOC2 BCL6 TET1 HEL-S-20 FGF2 DLX5 GRIA3 IGF1R GRIA4 EZH2 CNP MYT1 NF1 FUT8 YBX1 IGF1 POU3F2 HNRNPH1 CEBPD MEF2C RPS6 PSIP1 FKBP5 CDON UBE3A RBFOX1 TET3 DLX6 NREP PRPF38A POU4F1 HNRNPF IGF2 SP1 SP3 GAD1 FUS PTEN GRIN1 SGK1 CTCF SMC3 GPRIN1 BDNF TARDBP HDAC1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260610%WP5236%HOMO SAPIENS Markers of kidney cell lineage PECAM1 NOTCH1 NTN1 EGLN3 EPO EGLN2 AXIN2 FGF7 HNF1A EMX2 WT1 TNC KIT FGF8 NT5E HNF4A SMAD1 KDR LHX1 TCF2 DKFZp781O1323 REN TLX1 NPHS1 NPHS2 WNT4 NOTCH2 CITED1 SIX1 DACT1 ACTA2 KCTD1 DES TSHZ3 PBX1 TBX18 FAT4 VSX2 SALL1 SIX2 EYA1 FOXD1 EGLN1 OSR1 BMP7 TCF21 DCN PAX2 ALDH1A2 RSPO3 RSPO1 BMP4 SFRP1 GDNF OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260610%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 ACOX1 ELOVL5 ACOX3 FADS1 ELOVL2 PLA2G6 FADS2 ACSL1 FACL4 PLA2G4B ACSL3 MALE INFERTILITY%WIKIPATHWAYS_20260610%WP4673%HOMO SAPIENS Male infertility H2BW1 TMEM132E CLU UBE2B XRCC3 TAS2R38 PUM2 DAZL PIWIL2 PIWIL1 PIWIL4 SPO11 HORMAD2 MSMB SOX5 PACRG TEX15 CXXC1 OR2W3 MAS1L P1 TRIP13 USP26 PEX10 CDC42BPA MLH3 CTCFL SEMG1 BRDT GPX1 TNF EP300 APOB SLC46A1 H4C9 XRCC5 MTHFD1 CDK9 SRD5A2 SIRPA MTR PRMT6 PSAT1 RFC1 CYP26B1 REC8 FAT10 MTRR AHR BCL2 MDM2 PMS2 ATM AHRR CHD2 AGO2 H3-4 NQO1 ABCB1 TCN2 CYP17A1 GNAO1 HMGA1 PEMT HEL-S-61p CREBBP PON2 PON1 BRCA2 MMP9 XPC SHMT1 CYP1A1 THBS1 MMP2 ERCC1 ERCC2 NFE2L2 INSR NR3A2 POLG DND1 KDM3A NOS2 CCNK PRDM9 SIRPG HEL110 EPSTI1 SLC16A7 RAG1 NANOS1 PRM2 PRM3 FOLH1 SPATA17 ETV5 MSH4 MSH5 TSSK4 DDX4 DAZ4 DAZ3 TNFSF6 VCX DAZ2 STRA8 MOV10L1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260610%WP34%HOMO SAPIENS Ovarian infertility TBP FMR1 SMPD1 EGR1 NR1i1 DAZL FSHR SYNE2 CREB1 PRLR TSC2 CEBPB TSC1 CCND2 NR3A2 PTGER2 NR5A1 LHCGR NCOR1 FIGLA DMC1 PGR ZP3 MTOR CDK4 ZP2 RAD51 ATM CDKN1B MSH5 INHA GJA4 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260610%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F13B FGA PLG F2 HEL-S-78p F13A1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260610%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR1 AGTR2 ACE2 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP5414%HOMO SAPIENS IDO metabolic pathway KYNU GOT2 KMO TDO2 KYAT3 IFNG AADAT KYAT1 IDO2 TNF IDO1 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260610%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling DDIT4 CREB1 ITGB1 VEGFB VEGFC ITGA4 ITGA2 ITGB7 GNGT1 PELO HIF3A GNGT2 COL11A2 PFKFB2 PFKFB1 PFKFB4 PIK3IP1 IL6R IFNAR2 IFNAR1 GNG3 GNG10 JAK3 GNG5 GNG4 GNG7 GNG8 GNG12 GNG11 GNG13 IFNB1 IRS4 GNB2 GNB1 FGF16 CRTC2 ATF2 RPS6 TCL1B TCL1A PPP2R1B CREB3L3 PPP2R1A CREB3L4 CREB3L2 KPG_010 CDC37 ATF4 PDGFA EPHA2 LPAR2 LPAR3 PRKAA2 INS IFNA7 GYS2 OSMR ITGB3 PRL PHLPP2 PHLPP1 ITGAV GYS1 OSM CSHL1 KITLG GHB3 CSF3 ITGA6 CSF3R CHRM1 EPO RAB2A FGF3 FGF4 FGF6 FGF7 FGF9 PRLR EFNA5 EFNA4 FGF20 FGF22 FGF21 EGFR FGF17 EFNA1 EFNA3 FGF14 EFNA2 FGF19 FGF18 GNB4 IL7R ITGA2B FGF10 TNC HSP90AB1 FLT4 GHR PPP2R5E PPP2R5B PPP2R5A PPP2R5D COMP PPP2R5C IBSP CREB3 TNR IL3RA CREB5 COL4A2 ATF6B COL4A1 GNG2 COL4A4 PPP2R3C COL4A6 ANGPT4 ANGPT2 PPP2R3A EPOR PPP2R2C PPP2R2B VTN PPP2R2D PDGFD CHAD PDGFC COL1A1 GSK3B COL1A2 PIK3R2 COL5A3 COL5A2 PIK3R1 ITGB4 FOXO1 RAB8A NRAS LAMC2 LAMC1 MLST8 ITGB8 FOXO3A ITGB6 ULK1 ITGAE VWF COL2A1 ITGA7 SLC2A2 SLC2A3 LAMA5 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 RELN LAMB3 LAMB2 LAMB1 VEGFD XB LPAR4 ITGAX LPAR1 CAB39 STK11 PRKAA1 CSF1 RAB14 ACACA STRADA IRS1 PIK3CD FGF8 IL2 NGF EIF4E EIF4B FGFR4 RPS6KB1 FOXA1 PIK3R4 MAP2K1 MAP2K2 HGF TSC2 TSC1 EIF4E1B RAF1 EIF4EBP1 PPP2CA RHEB FGF13 MDM2 GRB2 FGF12 CDKN1A PIK3R5 CDKN1B PTEN F2R RPTOR CASP9 NGFR HEL-S-125m HRAS JAK1 PIK3CA SOS1 ELAVL1 RAB11B AKT1S1 MAPK1 PPARGC1A MAPK3 ITGAM BAD IKBKB AKT3 IKBKG MTOR LIPE KIT CSF1R PDGFRA FLT1 RPS6KB2 ANGPT1 RAB10 FGF2 HIF1A VEGFA IGF1R KDR PIK3C2B FGFR2 PDPK1 THBS1 EGF CHRM2 FGFR1 IGF1 opn INSR SLC2A4 IL2RG COL3A1 FGFR3 IL2RA IL2RB NOS2 GNB3 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260610%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ACAD9 NDUFAF2 NDUFAF1 NDUFA5 NDUFB11 NDUFA13 NDUFA12 TMEM186 C3orf60 TMEM126B NDUFC2 DMAC1 NDUFC1 DMAC2 TMEM70 NDUFS6 COA1 NDUFS5 NDUFAF6 NDUFS4 NDUFAF4 NDUFS1 ND2 ND5 ND4 NDUFB9 ND6 NDUFB8 NDUFB7 NDUFB6 TIMMDC1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB10 NDUFB1 ECSIT NDUFV3 NDUFV2 NDUFA10 NDUFA7 NDUFA6 ZNF183 NDUFA3 NDUFA2 ND4L NDUFAB1 NUBPL NDUFS3 ND1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260610%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 TLR7 MAVS TNFRSF11A RIGI IRF3 TLR8 IFIH1 TLR3 MR1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5049%HOMO SAPIENS Glycolysis in senescence PRKAA1 HEL-S-133P RB1 HEL-S-68p HEL-S-30 ENO1 HEL-S-162eP 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MRPL20 HES5 IFIT1 ELAVL1 TNFRSF14 B3GALT6 PEX10 SKI CALML6 ARF6 TRIM25 TRAF2 ATAD3A IFIH1 PANK4 TRAF5 INTS11 INTS13 INTS14 PARD6B INTS10 UBE2J2 GDE1 TMEM52 NOC2L COMMD1 METTL14 SDF4 PLEKHN1 SMAD4 CCNL2 SAMD11 MUSK LRP4 ISG15 SSU72 VEGFA PEX2 ATAD3C GLTPD1 VTN ACAP3 CD160 GNB1 RER1 SCNN1D C1QTNF12 TNFRSF4 PEX5 MXRA8 PRKCZ RBX1 VWA1 AURKAIP1 TNLG2B TNLG2A PERM1 AGRN KLHL17 MEPCE GRIK2 PHKG2 PUSL1 TAS1R3 HES4 HEL-S-72p OR4F5 OR4F3 CDK11A CFAP74 MIB2 PEX12 MMP23B RNF223 DKK3 MORN1 TNFRSF18 BTLA TMEM278 FNDC10 ANKRD65 INTS4 INTS9 SLC35E2B C1orf159 SMAD2 NADK PLCH2 TGFB1 MCM2 DVL1 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260610%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function PRKCB PRKCI PRKCH TRPA1 PRKCA TRPV1 PRKCQ PRKCZ MMP21 MMP20 MMP25 MMP2 MMP24 MMP27 MMP28 MMP7 MMP3 MMP10 MMP12 MMP11 MMP14 MMP16 MMP15 SCN9A MMP23B MMP17 SCN10A MMP19 SNAP25 SORD SLC2A3 PRKCE NOS2 PRKD3 SCN8A AGER HEL-S-62p BDNF MMP9 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 FAAH CYP1A1 PRKAR1B PRKAR1A CYP3A4 CYP2C19 CYP2C9 MAPK8 MAPK1 MAPK3 DAGLA CNR1 PRKACG MAPK14 NAPEPLD DAGLB ADCY1 AHR MAPK9 CNR2 MAPK12 MAPK13 MAPK11 ADORA2A CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation KCNJ6 HES5 NOTCH1 CASK ITGB1 TH HES1 SYP CDH2 PIG59 MSX2 SOX9 SLC1A2 SLC1A3 GLS HOMER1 GRIN2B DLG4 GABBR1 DPPA3 ZFP42 AP2A1 AP2A2 CLDN11 ROBO1 SNAP25 SLC6A5 SLC6A9 TWIST2 RIMS2 HOMER3 SLC6A2 BSN RBFOX3 CACNG2 FBXO15 UNC13A TBR1 LIN7A FUT4 CD24 PCLO ERC1 SLC18A3 SNAI1 DPPA2 SOX17 SNAI2 ERAS GAD1 GLRA1 GLRA2 GLRA3 SLC17A6 SLC17A7 GRIN1 GLRB RIMBP2 NGFR DLG2 NLGN1 PECAM1 CD34 ITGA6 NODAL FGF4 KLF4 OLIG2 SOX10 GABBR2 HOMER2 PAX3 SHANK1 SHANK3 S100B MBP GATA6 TNC LEF1 ADRA2C ADRA2B HTR5A ACHE ADRA2A TBXT HNF4A MAP2 NEF3 FOXA2 CNP MSX1 HTR1A LHX1 MOG GAD2 NEFL AQP4 SLC6A3 SOX2 GATA4 GFAP TWIST1 LMX1B CSPG4 TPH1 TPM1 ChAT GPHN FOXD3 FEV HES3 ESRRB BMP4 MIXL1 POU5F1 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260610%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR MSRA SRM IL4I1 SMS TXN HEL-S-61p MAT1A CHDH MSRB2 MSRB3 AMD1 APIP MRI1 MTAP ADI1 ENOPH1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260610%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260610%WP3594%HOMO SAPIENS Circadian rhythm genes MAGED1 MAPK10 HCRTR2 HCRTR1 EGR1 SFPQ DDC HTR7 CREB1 DRD2 ZFHX3 NR2F6 TH PRKAA1 SIN3A SUV39H2 KMT2A TYMS STAR SUV39H1 EP300 MTTP CRTC1 CRX HDAC2 NTRK1 HS3ST2 JUND FBXW11 HOMER1 EZH2 SIX3 RPS27A SKP1 MYBBP1A CLDN4 TOP2A KCNMA1 IL6 NKX2-1 PROX1 SIK1 F7 DRD1 PRKDC NTRK3 GHRL AgRP ATF4 JUN GNA11 CDK4 PRKAA2 PML AHR MAPK9 HDAC3 BTRC PTEN TNFRSF11A NR1H3 DRD3 NGFR DRD4 PHLPP1 DYRK1A NLGN1 C1orf51 NPY2R PROK1 UTS2R HEL-S-2 KCNH7 USP2 CHRM1 SOX14 CARTPT PSPC1 TIMELESS RELB UTS2 OPN4 OPN3 BTBD9 PRF1 SETX NAMPT FBXL3 KDM5A HEBP1 DDX5 RBM4 MAPK8 PROK2 KLF10 KCND2 SFTPC PAX4 MC3R PPARGC1A THRAP3 NFIL3 METTL3 CIPC NR1D1 RBM4B NPS NCOR1 ATOH7 PROKR1 NOCT ARNT2 CAVIN3 PASD1 BMAL2 RAI1 OGT ADCY1 PPP1CC GIG8 NONO PER2 HEL-S-80p hCG_2014051 HNRNPD AANAT MAGEL2 CSNK1D SIRT1 PER1 MTNR1A PER3 MTNR1B UBC CRY2 CRY1 GHRH TCF2 RORA CRH GSK3B CHRNB2 ATF5 CPT1A BHLHE41 RORB SLC9A3 NPAS2 TPH2 NR1D2 LEP PPARG TPH1 UBE3A CREM BHLHB2 ID4 NOS2 ROCK2 DBP ADA GFPT1 ID3 ADORA2A NR1C1 HDAC1 CCAR2 AVP RORC KLF9 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260610%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1LI2 RHOT1 BAX MFN2 DYNC1I1 RAB7A DCTN1 RAB3B SNCA DYNC2H1 DYNC1H1 TRAK1 ATAT1 KIF1B MAP2 RABAC1 CASP8 SYPL1 CASP3 DYNC2I2 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260610%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 MORC3 ELL BCLAF1 STK38 TRIM35 SUZ12 SETX RBBP7 JARID2 EED THRAP3 RBBP4 AEBP2 EZH1 EZH2 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260610%WP1422%HOMO SAPIENS Sphingolipid pathway SPHK1 SGMS2 PPP2CA UGCG SGPP2 GBA2 ACER1 KDSR PLPP1 SPTLC2 CERS3 SPTLC3 CERS5 SPTLC1 SERINC1 CERS2 CERS6 CERT1 CERK SGMS1 UGT8 SGPL1 ASAH2 SPHK2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260610%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias UROD UROS HMBS CPOX ALAS2 ALAS1 FECH FERROPTOSIS%WIKIPATHWAYS_20260610%WP4313%HOMO SAPIENS Ferroptosis HMOX1 GCLC CBS DKFZp762B153 CP FTL ACSL1 ACSL6 FACL4 ACSL5 ACSL3 ALOX15 COQ2 HMGCR VDAC3 FDFT1 STEAP3 SAT2 CHMP6 CHMP5 SLC3A2 DPP4 FTMT PCBP1 LPCAT3 SLC11A2 AKR1C1 CTH AIFM2 GCLM AKR1C2 DKFZp686F0183 SLC7A11 FTH1 CYBB PHKG2 SLC39A8 SLC38A1 NOX4 HEL-S-64p CISD1 TF TFRC BACH1 POR IREB2 SLC40A1 SLC39A14 HEL-S-102 GPX4 MAP1LC3A MAP1LC3C PRNP UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260610%WP5158%HOMO SAPIENS Urotensin II mediated signaling HDAC5 CAMK2A UTS2R HMOX1 UTS2 IL1B VCAM1 ARHA MAPK8 MAPK1 MAPK3 EGFR TNF STAT3 IKBKB PTPN11 MAPK14 CHUK EP300 BAX IRF3 RELA PLN NCF4 TRPC4 DDIT3 CREBBP ALOX5 MMP9 CYBA NCF1 HSPA2 NCF2 AIFM2 IL6 MMP2 GSK3B CYBB COL1A1 PCNA NFKB1 NOX4 GSK3A COL2A1 COL3A1 CCNE1 SMAD2 ACTA2 CDC2 ESPL1 ABCA1 CDK2 BCL2 MAPK9 TGFB1 AGTR1 PTEN NPPB CASP9 NPPA CASP3 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260610%WP259%HOMO SAPIENS Nifedipine activity MAPK1 PTK2B CYP3A4 BDKRB2 MAP2K1 PCNA KDR HEL-S-44 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260610%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAPK10 TGFBR2 NTN1 AXIN2 CSNK1A1 ARHA MAPK8 MAPK1 DCC MAPK3 BAD APC ARAF AKT3 TBK1 BAX BCL2L11 LEF1 TCF7L2 TCF7L1 RALA CSNK1A1L MSH3 SMAD4 REL APC2 CCND1 MYC MAP2K1 GSK3B BBC3 BIRC5 AXIN1 TGFBR1 MSH6 MSH2 RAC3 RAF1 DDB2 POLK SMAD2 JUN PMAIP1 GADD45B GADD45A GADD45G BCL2 MAPK9 TGFB1 BAK1 CYCS EXOC2 CDKN1A CASP9 CASP3 RALB APPL1 PTGS2 RAC1 FOS MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260610%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer SESN3 PMAIP1 BAX TNFRSF10B CHEK2 MDM2 ATM BBC3 TP53AIP1 PTEN EI24 CASP9 SHISA5 CASP8 ZMAT3 APAF1 CYS1 PERP CASP3 DDB2 SIAH1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C18 CYP2C19 CYP2C9 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260610%WP4921%HOMO SAPIENS Mitochondrial complex III assembly CYB UQCRC1 UQCRFS1 UQCC UQCRC2 UQCRB UQCR11 UQCR10 UQCRH CYC1 UQCC3 UQCC2 UQCRQ TTC19 LYRM7 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260610%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2B CCND2 CAMK2D MEF2C NKX2-5 MEF2D KLF4 MYOCD WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260610%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK10 NPHP3 WNT2B ARHA MAPK8 WNT5B INVS WNT9B FZD7 WNT16 FZD8 WNT3 WNT4 DVL2 WNT10B WNT10A DVL3 FZD3 FZD5 FZD4 WNT7B FZD9 WNT7A MAPK9 WNT3A LRP5 LRP6 DVL1 FZD1 WNT1 FZD2 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260610%WP5300%HOMO SAPIENS TROP2 regulatory signaling PECAM1 NOTCH1 PRKCA CLDN7 RB1 ACVRL1 CCND1 PSEN2 CHEK1 ITGB1 IGF1 PIK3R1 NFKB1 EGFR STAT1 CDKN2A CCNE1 JUN BAX MDK IGF2 CDK4 CLDN1 CDK2 BCL2 PAK4 IGF2R CDKN1B PTEN ABCC1 SRC TLN1 IGF1R HEL113 RAC1 TACSTD2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260610%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia CA8 PLCB3 HOMER3 PLCB4 GNA11 PLCB1 PLCB2 ATP2B2 GNA14 GNA15 GRIA2 CACNA1A GRIA3 TRPC3 GRIA4 RYR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260610%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 HEL-S-22 COX5A CYP2J2 COX8A CYP2C9 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome MYO1C PARG MYBBP1A LRRC18 OGDHL GDF5 CUL5 ARHGAP22 SIRT6 ITCH UVSSA BMPR1A EIF4ENIF1 SMAD9 HSF4 FAM170B CEFIP VSTM4 DKFZp781O1323 DRGX KDM4D C10orf53 ERCC5 RGMB PCNA TMEM273 WDFY4 MAPK8 SMARCC2 NOG ATF2 RIF1 MEN1 ChAT BAZ1B BCL2 HSF1 SLC18A3 ELOA DLD DDX21 SMAD1 JUND SIRT1 BMP2 SMARCA5 NLRP3 DEK AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260610%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 SOS1 FRS2 NELFA NELFE NAT8L NSD2 TMEM129 PIK3R1 FAM53A CKAP5 MAPK1 LETM1 NICOL1 TACC3 SLBP MAPK3 ERI1 NELFCD FGFR3 CLTCL1 NELFB GRB2 POLN H3F3B UBE2J2 CBL FGF2 PDGF PATHWAY%WIKIPATHWAYS_20260610%WP2526%HOMO SAPIENS PDGF pathway PLCG1 MAP2K4 WASL SOS1 CDC42 MAP2K1 ARHA SHC1 MAPK8 PAK1 PIK3R1 MAPK1 NFKB1 MAPK3 RAF1 STAT1 STAT3 TIAM1 PTPN11 PDGFA JUN CHUK COX2 NFKBIA GRB2 VAV1 SRC HRAS JAK1 MAP3K1 RAC1 VAV2 FOS BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260610%WP5234%HOMO SAPIENS Bardet Biedl syndrome ARL3 DYNLT2B SUFU DYNC2LI1 PKHD1 NPHP3 IFT80 IFT74 KIF7 LZTFL1 DCDC2 IFT81 INVS TTC8 TMEM107 CNGA1 PTCH1 CEP164 WDR35 BBS2 NEK8 BBS10 EVC BBS1 CLUAP1 BBS12 RP2 TMEM216 FLCN EFHC1 FUZ BBIP1 CNGB1 ZIC2 CRX PKD1L1 ARL13B TMEM67 MKS1 SDCCAG8 RAB23 PDE6D IFT27 USP9X EVC2 PCARE SCLT1 OCRL IFT52 BBS9 CEP41 BBS7 IFT57 TRIM32 TRAF3IP1 CEP290 PKD1 BBS5 BBS4 IQCB1 SCAPER IFT140 IFT43 GLI3 NEK1 EFHC2 DYNC2H1 INPP5E CFAP418 CFAP410 DYNC2I2 GPR161 WDPCP IFT172 SMO CEP104 ARL6 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence AKR1B1 EPHX2 RB1 FADS2 ELOVL5 FADS1 SLCO2A1 HEL-S-53e GPX1 PTGIS ALOX15 ALOX12 HEL-S-22 ALOX15B PRXL2B PTGES PTGES3 CYP4F8 CDKN1A ALOX5 ELOVL2 MAPK11 ALOX5AP SIRT1 NAT2 DPEP2 LTC4S PTGS2 ALOXE3 HEL-S-298 HPGD PTGS1 DECR1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP69%HOMO SAPIENS T cell receptor signaling SOS1 CRK CDC42 CREB1 MAPK8 PAK1 MAPK1 PTK2B MAPK3 IKBKB PTPN11 MAPK14 IKBKG CHUK RELA TRAF6 GAB2 VAV1 ZAP70 LCK CBL ITK FYN ICOS GRAP2 WAS PLCG1 REL LCP2 CARD11 NFATC2 PDPK1 NFATC1 CD3G PRKCQ CD3E MAP3K8 BCL10 CRKL CD8A SH2B3 MAP2K1 MAP2K2 LAT SHC1 PIK3R2 NCK1 PIK3R1 NFKB1 MAP3K14 ATF2 HEL-S-81p RAF1 PSTPIP1 VAV3 JUN FYB1 MAPK9 NFKBIA GRB2 MAP3K7 RIPK2 HRAS CD3D MAP4K1 FOS 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation KIF1C MDH2 PTPMT1 SFN RHBDD2 DAPK2 POR ZP2 SRRM3 YWHAG LMNA HEL-S-102 RAF1 TMEM120B TMEM120A SSC4D ZP3 STYXL1 HEL163 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260610%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 SLC10A2 ABCC3 SLC51A SLC51B ABCC2 ABCB1 FABP6 ABCB11 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome FBXO47 MLLT6 TMEM132E FBXL20 NEUROD2 MIEN1 ZNHIT3 C17orf78 ASIC2 GAS2L2 HEATR9 TAF15 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ARHGAP23 HEL-S-6a TBC1D3K STAC2 CDK12 SPMAP1 CCL14 CCL13 CCL11 MRM1 ACACA CCL18 RPL23 CCL15 PNMT CACNB1 MED1 CCL5 CCL4 CCL3 CCL2 CCL4L2 RFFL LHX1 ERBB2 TCF2 MMP28 GRB7 PEX12 CCT6B DHRS11 PIP4K2B PGAP3 TBC1D3B TBC1D3E CCL8 TBC1D3C CWC25 PIGW CCL7 TEC TBC1D3I TCAP AATF CCL1 IKZF3 CISD3 DUSP14 TBC1D3H RDM1 SOCS7 ARL5C CCL3L3 C17orf50 GPR179 CCL16 STARD3 FNDC8 UNC45B SLC35G3 SRCIN1 PPP1R1B SLFN12 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 SLFN5 GGNBP2 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260610%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide IFNB1 MYD88 TLR4 NFKB1 TLR9 IRF3 MAP1LC3A IFNG TNF TRAF6 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260610%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCB NFATC2 PRKCA CCND1 CSNK1A1 GSK3B BCL9 ARHA MAPK8 RYK TSC2 TSC1 MAPK1 AXIN1 GCKR CSNK1G1 DKFZp686L0365 PPARG ROR1 GSK3A DVL2 APC ROR2 STM7 DVL3 TCF4 MTOR FRAT1 CTBP1 LEF1 PI4K2A MAPK9 CDK6 TCF3 LRP5 TCF7L2 SOX1 MAP3K7 hCG_2014051 LRP6 NLK CSNK1D DVL1 RAC1 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260610%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection EIF2AK1 MBTPS2 PPP1R1A MAPK8 PPP1R3B PPP1R15B PPP1R13B PPP1R11 ERN1 PPP1R10 PPP1R9A PPP1R3A PPP1R7 PPP1R2 PPP1R8 PPP1R12C PPP1R16B PPP1R14B PPP1R14C PPP1R16A ATF4 PPP1R3G PPP1R3F PPP1R3C PPP1R3E PPP1R1C sm-M20 PPP1R3D PPP1R14D EIF2AK2 EIF2S1 BCL2 PPP1R15A PPP1CC XBP1 HEL-S-80p DDIT3 PPP1R14A PPP1R1B HEL-S-89n MAP1LC3A MBTPS1 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260610%WP4658%HOMO SAPIENS Small cell lung cancer RARB ITGA6 PIK3CA CDKN1C BIRC7 ITGB1 COL4A3 ITGA2 COL4A5 RXRA E2F3 CDKN2B TRAF1 IKBKB AKT3 IKBKG CHUK BAX ITGA2B TRAF2 PIK3CD CKS1B CKS2 TRAF3 RELA TRAF6 TRAF5 COL4A2 COL4A1 COL4A4 COL4A6 LAMB4 BCL2L1 SKP1 RB1 CCND1 MYC PIK3R3 PIK3R2 NFKBIB PIK3R1 E2F2 LAMC2 LAMC1 NFKB1 APAF1 DDB2 CCNE2 CCNE1 BIRC2 POLK BIRC3 LAMA5 LAMA1 NOS2 LAMA4 FHIT LAMA3 RXRB GADD45B RXRG GADD45A CDK4 GADD45G CDK2 BCL2 CDK6 LAMB3 NFKBIA LAMB2 BAK1 CYCS LAMB1 CDKN1A CDKN1B PTEN TRAF4 CASP9 CASP8 CASP3 ITGAV PTGS2 MAX TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260610%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection MYD88 STAT2 IKBKE TMPRSS2 MAVS RIGI TLR4 STAT1 TBK1 IRAK4 IFNAR2 ACE2 TLR9 EIF2AK2 IRF3 TREML4 IFIH1 TRAF3 TLR3 TYK2 TRAF6 IRF7 TLR7 OAS1 IFNAR1 IRF9 OAS2 JAK1 OAS3 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260610%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 RET MYOG TRIM63 EP300 FBXO32 MYC ADRB2 H3Y1 MYOD1 MYF5 H3Y2 DUX4 CDKN1A PAX7 NR3A2 PPARGC1A VEGFA LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260610%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 CPT1A ACACA ADIPOR2 ADIPOR1 LEP PRKAG1 PRKAB1 LEPR INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260610%WP1984%HOMO SAPIENS Integrated breast cancer pathway CDK7 XRCC3 BMPR1A TGFBR2 CREB1 RHO STK11 SMAD6 SELENOK WEE1 HIPK2 TRADD APOBEC3G EP300 HMGCR IRS1 CERK ZMYND8 NAB1 PIAS1 MAP3K7CL ZMIZ1 ALKBH1 RALGAPA1 CCNB1IP1 LGALS13 PLK3 SMAD4 ERAL1 FER PIGR FOSL2 RASGEF1A RASGRP3 FADD FOSL1 DCAKD ITPKC EDAR USP16 TFPI USP21 FILIP1 ATF1 RB1 CCND1 CHEK2 MYT1 MYC CHEK1 FAU TSC2 TSC1 CDC25B AURKA MSH6 TGFBR1 MSH2 MAP3K13 GSK3A BLM ZNF655 USP15 SMEK1 DAG1 RAP1A MAP3K7IP1 BARD1 SMAD2 JUN PLK1 SMARCA4 RHEB GADD45A CDK4 SP1 NOXA1 PML AHR BACH1 PPP4R3B UBE2F CDK2 BCL2 MDM2 RAD51 ATM ATR PTEN BRCA1 CASP9 CASP8 CASP3 JAK1 RAC1 CDC42 PAK1 MAPK1 EGFR BAD ARAF STAT1 GRN RRAS MRE11A MTOR CHUK RAD50 BAX RPP38 RALA SMAD1 CSNK1D SIRT1 BRCA2 VEGFA NUP85 GDI1 TPR NF1 PIK3R2 FOXO1 NFKB1 PKIA ANXA1 BMPR2 DHTKD1 BAK1 MYCBP2 HDAC1 MAX INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260610%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL-21 IL18RAP NFATC1 IL6 IL22 HLA-DMA MAF RORA TLR4 FOXP3 NFKB1 TBX21 IFNGR1 STAT1 IL23A IL2RG TNF STAT3 IL5 SMAD2 JUN GATA3 IL12RB1 IL10 IL21R IL12A TLR5 IL2 IL4 TGFB1 IL13 IL23R IL17F NOD2 IL18 STAT4 IL1A IFNG RORC ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260610%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL5 MS4A2 IL1RL1 FCER1G CRLF2 IL25 IL33 TYK2 IL4 IL13 IL13RA1 OSMR JAK3 TSLP STAT3 IL2RG FCER1A NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260610%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAPK8 ERBIN IKBKG CHUK MAP3K7 EPHB2 CD40 RELA IKBKB CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260610%WP4191%HOMO SAPIENS Caloric restriction and aging IGF1 MTOR PPARGC1A PRKAB2 SIRT1 NAMPT VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260610%WP3871%HOMO SAPIENS Valproic acid pathway CYP2A6 CYP2B6 IVD HSD17B10 ACADSB ABAT HADHB HDAC1 EHHADH CYP2C9 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260610%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGTR1 TMPRSS2 ACE2 REN MAS1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2064%HOMO SAPIENS Neural crest differentiation HDAC5 NOTCH4 RBPJ HES5 NOTCH1 MYB AXIN2 HDAC8 DLL3 DLL4 ITGB1 SOX5 OLIG2 SOX10 HES1 CTBP2 MPZ NEUROG1 PMP22 CDH6 ASCL1 PAX3 GBX2 DVL3 TCF4 COL11A2 MBP FGF19 TFAP2B HDAC10 FGF8 CDH2 MSX2 WNT3A TBX6 SOX9 TCF7L1 HDAC2 SMAD1 ISL1 FGF2 HOXA1 DLX5 HAND1 HEY2 OLIG1 TFAP2A FGFR2 MSX1 ZIC5 DMBX1 MIA LHX1 OLIG3 DCT ZIC1 HOXB1 PRTG ID1 MYC LHX5 GJB1 GSK3B FGFR1 GFAP TLX2 AXIN1 PAX7 WNT8A NFKB1 TWIST1 NFKB2 DVL2 FZD3 COL2A1 FGFR3 NOTCH2 HDAC11 PHOX2B FOXD3 SNAI1 SNAI2 HDAC3 BMP7 BMP4 HDAC7 HDAC1 DVL1 RHOB WNT1 NOTCH3 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis AKR1C1 SRD5A2 HSD3B2 AKR1D1 CYP21A2 HSD3B1 CYP17A1 CYP11A1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260610%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 NAE1 CBFB RBX1 ELOC UBA3 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CDC27 AMER3 STMN2 MZT2A FAM168B ARHA CCDC74A TUBA2 POTEE GPR148 CCDC42 APC ARHGEF4 STAT3 RAC1 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260610%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP1A2 HEL-S-4 CYP1A1 ADH1C ALDH2 CYP3A4 CYP2A6 CYP2E1 HEL-S-117 CYP4A11 ADH7 HEL-S-53e ADH1A INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260610%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PDHA1 RPS6KA2 RPS6KA1 HEL-S-133P MAP2K1 NAMPT MAP2K2 CPT1A HEL-S-304 MAPK1 PPARGC1A MLST8 MAPK3 RAF1 ARAF PFKFB2 MTOR ACSS1 DLAT DLD RPTOR GPX4 HEL-S-30 HEL-75 GLS PKLR SLC16A3 HEL-S-281 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260610%WP4725%HOMO SAPIENS Sphingolipid metabolism overview SPHK1 SGMS2 SGPP1 UGCG SMPD1 SGPP2 DEGS1 PLPP3 GBA2 PLPP2 KDSR PLPP1 SPTLC2 CERS3 SPTLC1 CERS2 CERS6 CERK SGMS1 LASS1 UGT8 DEGS2 SGPL1 SPHK2 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260610%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R2 PIK3R1 PIK3CA PIK3R5 PIK3R4 PIK3CD PIK3C2G PIK3C2B PIK3R3 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway MFGE8 DNER NR3C1 CDKN1C STOM NR1i2 SLC26A2 FGD4 RXRA IL11 PDE4B PPP1R14C THBD SPRY1 AMIGO2 ZIC2 B3GNT5 ACKR3 ALOX5AP TNFAIP3 CCL2 NR1I3 RGS2 SLC19A2 EPB41L4B NFKB2 ARL5B ENC1 ANKRD1 ANGPTL4 SRGN S100P EDN2 TSC22D3 NAV3 BHLHB2 ADGRF4 CDC42EP3 SCNN1A BIRC2 PMP2 BIRC3 ABHD2 PRRG4 JUN GPR153 SERTAD2 MGAM GADD45B CAVIN2 PLK2 DNAJC15 TNS4 KTN1 CPEB4 PTGES3 CCL20 FGFBP1 SNAI2 POU5F1 PTGS2 TGFBR3 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260610%WP550%HOMO SAPIENS Biogenic amine synthesis ChAT GAD2 DDC HDC PNMT DBH PAH TH ACHE GAD1 MAOA ASMT AANAT TPH1 GDNF SIGNALING%WIKIPATHWAYS_20260610%WP5143%HOMO SAPIENS GDNF signaling AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260610%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension FTCD GPT2 GLUD1 HAL UROC1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260610%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260610%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260610%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling PDHA1 SLC2A3 MTOR PFKFB4 PIK3CA NR1i1 HEL-S-133P IL10 PRKAA2 MYC IL12A GSK3B RELA TSC2 RXRA TSC1 CYP24A1 CD80 HK3 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260610%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC5A5 EGR1 NR3C1 TXN HES1 GPX2 TNF GPX3 GSTT2 PDE4B EP300 SLC5A1 SLC5A2 PLTP SLC6A20 APOA2 APOC3 APOA5 B3GNT5 SLC6A18 SLC5A8 CCL2 NR1i1 GCLM ABCB4 NR1I3 ABCG8 NR1H4 ABCG5 ABCB11 TGFA PCK1 S100P POLK CDC37 EPHA2 CYP7A1 SLC39A2 SLC39A1 SLC39A3 NR1H3 GSTM1 TGFBR3 MFGE8 HMOX1 UGT1A1 ACOX1 SERPINB2 GSTM4 IL1B IL11 DBI FABP1 EGFR UGT1A4 FGF19 UGT1A3 HSP90AB1 UGT1A9 UGT1A7 AMIGO2 PTPA ACKR3 SLC6A19 HEL-75 ALOX5AP PTGR1 GPAM SLC6A3 RGS2 FOXO1 ANGPTL4 BIRC2 SLC2A2 BIRC3 SLC2A3 CYP3A7 TNS4 FGFBP1 TGFBR2 CDKN1C STOM SLC26A2 DNAJB1 KLK15 NR0B2 PPP1R14C SCD FASN THBD AGER CPT2 IL2 EHHADH SLC6A13 SLC27A1 SLC6A11 JUNB SERPINA1 JUND TNFAIP3 CCND1 SQSTM1 MYC BAAT CYP8B1 SLC39A9 FTH1 SLC7A11 SLCO2B1 SLC39A6 IP6K3 SLC39A5 SLC27A5 GSTM2 SLC39A8 SLC6A17 SLC6A16 SLC19A2 HGF SLC5A7 SLC5A9 CES8 EPHA3 HEL-S-10 EPB41L4B MGST3 ARL5B MGST2 ENC1 ADH7 ANKRD1 SLC5A3 FKBP5 SRGN SLC5A4 EDN2 NRG1 SMC1A TSC22D3 SLC2A9 HEL-S-128m NAV3 SLC6A5 ADGRF4 SLC6A7 CDC42EP3 SLC6A9 SCNN1A UGT2B4 GSTM5 PMP2 ABHD2 SRXN1 JUN SLC2A6 PRRG4 SLC6A2 GPR153 SERTAD2 SLC2A7 UGT2B7 CDC2 SLC2A8 GADD45B SLC2A14 CAVIN2 PLK2 SLC2A11 CDK4 SLC2A10 DNAJC15 SP1 MGST1 SLC2A13 KTN1 CPEB4 AHR FGF13 HEL-S-25 SLC39A11 CAP2 GCC1 SLC39A10 PTGES3 MYOF SLC39A13 SLC39A12 AIP SNAI2 SLC39A14 ALDH3A1 AHRR SMVT CES3 SLC5A12 CDKN1B SLC5A10 GSTA5 GSTA4 GSTA3 CYP4A11 IFNG ME1 KAT2B HBEGF DNER NQO1 KEAP1 GCLC ABCC3 NCOA1 ABCC2 ABCB1 NR1i2 CYP2C19 CYP4F12 CYP2C9 SLCO1B1 FGD4 CYP2A6 RXRA CYP2B6 SRPX2 DNAJC7 PPARGC1A SMARCA1 SLC7A5 FTL SULT2A1 STAT3 NR1C2 BAX SPRY1 ZIC2 SULT1A1 SLC2A12 SLC6A8 SRC HEL126 CES2 CES1 CYP1A2 CYP1A1 CYP1B1 CYP3A4 MAFG MAFF CPT1A NFE2L2 NFKB2 SLC2A4 PDK4 BHLHB2 GSTM3 ALAS1 HEL-S-22 NCOA6 IL12B IL12A CCL20 TGFB1 IGFBP1 IL17B ACADM ABCC5 NR1C1 POU5F1 PTGS2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260610%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex CRP CD3G CD3E IL6 CD8B IGLL1 HLA-DRB5 CD8A MMP25 NRF CD2 LBP ZAP70 HLA-DRB1 LCK PRG3 CXCL8 FYN MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260610%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PLCG1 PIK3CA GABRB3 GABRB2 GABRB1 CREB1 AP2A1 AP2A2 PIK3R3 ARHA SHC1 PIK3R2 PIK3R1 NTRK2 CREM STAT3 ROCK1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 PTEN GABRG1 NGFR BDNF TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260610%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC MOB1A HMGCR TEAD2 RHOD TEAD3 TEAD4 PRKAA2 LATS1 PRKAB2 PRKAB1 RHO CTGF ARHA PRKAA1 LATS2 YAP1 STK4 PRKAG1 RHOB PRKAG2 CYR61 PRKAG3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260610%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway MAPK10 PIK3CA TGFBR2 CDC42 MAPK8 PAK1 MAPK1 E2F3 MAPK3 EGFR BAD ARAF STAT1 CDKN2A STAT3 IKBKB AKT3 IKBKG MTOR CHUK BAX PIK3CD RALBP1 RELA PLD2 HEL-S-34 RALA RPS6KB2 SMAD4 BRCA2 VEGFA BCL2L1 RPS6KB1 RB1 CCND1 ERBB2 EGF MAP2K1 MAP2K2 TGFA PIK3R3 PIK3R2 PIK3R1 E2F2 TGFBR1 NFKB1 RAC3 RAF1 DDB2 POLK SMAD2 GADD45B GADD45A CDK4 GADD45G PAK6 MAPK9 PAK4 CDK6 RAD51 TGFB1 dik BAK1 CDKN1A CASP9 RALB JAK1 RAC1 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260610%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways NEFH ERBB4 SOS1 MYL1 ARHA MAPK8 PAK1 MAPK1 EGFR APC GPX1 TMSB4X MYLK CBL SRC NEF3 MAP2K4 PLCG1 PFN1 NEFL ERBB2 MYC MAP2K1 GSK3B DAAM1 TGFA FZD10 HEL-S-44 SHC1 NCK1 WNT16 FZD7 AXIN1 FZD8 RAF1 FZD3 FZD5 FZD4 CAMK1 FZD9 PPP2CA JUN ROCK2 GRB2 ACTR3 CDKN1A ACTR2 CDKN1B PFN4 PFN2 ACTA1 PFN3 DVL1 FZD1 FZD2 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260610%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 MYD88 SOS1 DEPTOR MAPK1 RICTOR MAPK3 IL23A CDKN2A TNF CTLA4 IKBKB PPP3CC IKBKG MTOR CHUK BAX CCL19 IL12RB1 IFNAR2 PIK3CD RELA TYK2 IL2 ZAP70 LCK IFNAR1 STAT4 FYN ICOS IL18R1 GRAP2 PTPRC BCL2L1 PLCG1 IFNB1 LCP2 CARD11 PDPK1 NFATC1 CD3G PRKCQ CD3E BCL10 CCND1 MAP2K1 GSK3B MAP2K2 LAT TSC2 PIK3R1 TSC1 NFKB1 MLST8 FOXO3A RAF1 CD80 LTA JUN RHEB IL12B IL12A IL4 NFKBIA GRB2 IL23R CDKN1A HLA-DRB1 CCL28 PTEN IRF2BPL IL17A RPTOR HRAS CD3D IFNG FOS LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260610%WP3965%HOMO SAPIENS Lipid metabolism pathway PDHA1 ACACA PRKACG ABHD5 ACLY LIPE FASN PRKAR1B PRKAR1A PRKAA2 HILPDA PNPLA2 PRKAB2 PRKAB1 PRKAA1 PLIN1 ACSS2 PRKAG1 PRKAG2 PRKAG3 AKT3 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260610%WP5360%HOMO SAPIENS KCNQ2 related epilepsies PPP3CC CHRM1 PRKCA CSNK2A1 BACE1 KCNQ2 KCNQ3 PLCG2 CALM1 AGTR1 STX1A SCN1B P2RY1 BDKRB2 PPP1R10 AKAP5 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260610%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PHKG2 PPP2R2A GYG1 GSK3A PPP2R1B PPP2R1A PPP2CA HK2 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CALM1 PTPA GYS2 PYGB PYGM AGL PHKB GYS1 PHKA1 PYGL PPP2R3B PHKA2 HK3 PPP2R3A PPP2R2C PPP2R2B ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260610%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS SMUG1 SLC29A1 TK1 XRCC3 TYMP ABCC3 ERCC2 DPYD CYP2A6 TDG UMPS TYMS ABCG2 RRM1 RRM2 DHFR UCK2 ABCC5 UCK1 FPGS SLC22A7 UPP2 CES2 CDA GGH CES1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260610%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 CYP2A6 XDH NAT2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260610%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine MAOA SPR ASMT DHFR JDP1 PTS AANAT PNMT PAH DBH TH EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260610%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 MTOR MFGE8 TGFBR2 CD133 TSPAN8 ERBB2 WNT3A TGFA TGFB1 HGF NRAS AXIN1 TGFBR1 SMAD4 RAF1 EGFR DKK4 APC HRAS TGFBR3 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260610%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4EBP1 MYOG HBEGF HEL-S-52 MSTN DUSP14 NR4A3 IL1R1 ADAM10 IFRD1 IL18 JUND ANKRD1 IL1A EIF4E ATF3 IFNG VEGFA CYR61 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260610%WP2374%HOMO SAPIENS Oncostatin M signaling SOS1 EGR1 CREB1 MAPK8 MAPK1 PTK2B RICTOR MAPK3 STAT1 STAT3 IL6ST PTPN11 MAPK14 MTOR IRS1 RELA TYK2 STAT5B JUNB SOCS3 JAK3 JUND SRC HIF1A VEGFA PRKCB PRKCH PRKCA MAP2K1 MAP2K2 SHC1 PIK3R1 CEBPB NFKB1 RPS6 RAF1 PXN PRKCE CDK2 MAPK9 NFKBIA GRB2 CDKN1B OSMR CASP3 HRAS JAK1 OSM FOS MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260610%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress MAP2K4 PINK1 PIK3CA HMOX1 NQO1 KEAP1 GSX1 IL6 IPCEF1 PIP MAP3K5 CREB1 RPS6KA5 CHEK1 MAPK8 NFE2L2 FOXO1 TSC1 NFKB1 CXCL8 ATF2 TNF IKBKB CCNE1 MAPK14 IKBKG MTOR NOS2 RHEB CDK2 MAP2K3 BCL2 MDM2 NRF1 ATR CDKN1A PTEN IL1A SIRT1 PTGS2 BCL2L1 FOS NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260610%WP4331%HOMO SAPIENS Neovascularization processes REL NOTCH4 NOTCH1 SMAD9 ACVRL1 RELB DLL4 CXCL12 DKFZp781O1323 MAPK8 MAPK1 CXCR4 TGFBR1 NFKB1 NFKB2 MAPK3 SMAD2 KIT FLT4 RELA MAPK9 TGFB1 EPHB2 SMAD1 EPHB4 ANGPT1 HIF1A MMP9 KDR NOTCH3 KITLG MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260610%WP4318%HOMO SAPIENS Mitochondrial fission and fusion OPA1 MFN1 BNIP3 BAX MFN2 MIB1 FIS1 MTFP1 SH3GL2 BCL2L1 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260610%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCG1 PIK3CA PLCB3 PLCB4 IL6 PLCG2 RETN PLCB1 PLCB2 PLCD4 MAPK1 NFKB1 CXCL8 MAPK3 TNF IKBKB AKT3 PLCE1 MAPK14 IKBKG CHUK PLCD3 PIK3CD IL12B IL12A RELA NFKBIA MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260610%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCS1 HMGCR HMGCL ACAT1 GGPS1 IDI2 MVD FDFT1 FDPS MVK PMVK ACAT2 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260610%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PGAP3 DPM2 PIGW PIGF PIGS PIGU PIGT PIGX PGAP1 PIGO PGAP2 PIGN GPAA1 PIGP PIGM PIGV PIGY PIGC PIGB PIGA PIGK MPPE1 PIGL PIGH MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260610%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling MTOR IKBKG PDGFA PIK3CA SOS1 CCND1 MAP2K1 BCL2 GSK3B MDM2 MAP2K2 NFKBIA GRB2 CDKN1A CDKN1B FOXO1 MAPK1 NFKB1 CREBBP CASP9 RAF1 BAD KLK3 AKT3 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260610%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway SUV39H1 HEL-S-7 CDC37 NQO1 ECSIT FGF7 EXOC6 TGFB1 NRF1 PKD1 NFE2L2 IGFBP7 SIRT1 BMP2 COL2A1 DDR1 LOXL4 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260610%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease KCNN3 SP1 SP3 CALM1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer AXIN2 KREMEN1 WIF1 CSNK1A1 RYK NOTUM CTBP2 ROR1 ROR2 APC MACROH2A2 DVL3 PORCN CDK8 CHD8 SOST SENP2 LEF1 WNT3A CXXC4 TCF7L2 TCF7L1 hCG_2014051 CSNK1A1L NLK ATF3 FOSL1 TFAP2A EZH2 APC2 CSNK2A1 CCND1 MYC GSK3B CTNNBIP1 WNT2B FZD10 WNT5B CCND3 CCND2 WNT16 FZD7 AXIN1 FZD8 WNT3 RUVBL1 SFRP4 WNT4 DVL2 WNT10B WNT10A FZD3 FZD5 WNT7B FZD9 WNT7A JUN FRAT1 CTBP1 CDK6 FRAT2 NKD1 NKD2 TCF3 SOX17 LRP5 MAP3K7 CER1 CSNK2A3 CSNK2A2 LRP6 DKK1 DKK2 DKK4 SFRP1 SFRP5 DVL1 FZD1 CSNK2B WNT1 FZD2 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260610%WP26%HOMO SAPIENS S1P receptor signal transduction SPHK1 PLCB3 S1PR1 S1PR2 S1PR3 S1PR5 PLCB1 PLCB2 MAPK7 GNAI3 MAPK6 MAPK4 MAPK1 MAPK12 MAPK3 SPHK2 SMPD2 PIK3C2B GNAI1 AKT3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260610%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAP2K4 MAPK10 PIK3CA RPS6KA2 PRKCA RPS6KA1 CSNK2A1 EIF4A2 MAP2K5 RPS6KA5 MAP2K1 EIF4G1 MAP2K2 PIK3R3 PIK3R2 MAPK8 PIK3R1 MAPK1 MAPK3 RPS6 AKT3 EIF4EBP1 PIM1 PIM2 MAPK14 MTOR EIF4A1 RPS6KA4 MAP2K3 MAPK9 RPTOR RPS6KB2 EIF4E EIF4B MAP2K6 RPS6KB1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260610%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway TYROBP PTPN6 NCF1 NCKAP1L NCF2 PIK3CA FCER1G PLCG2 CYBB PIK3R3 LAT PIK3R2 PIK3R1 C1QA LYN ITGAM RAC3 TREM1 VAV3 C1QB SIGLEC7 PIK3CD FCGR1A VAV1 NCF4 SYK C1QC ARPC1B RAC1 VAV2 CYBA INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260610%WP1971%HOMO SAPIENS Integrated cancer pathway ATF1 RB1 CHEK2 MAP3K5 MYC CHEK1 BBC3 CDC25B MSH6 MSH2 CDKN2B BAD BLM STAT1 POU2F1 MRE11A BARD1 SMAD2 RAD50 PLK1 BAX CDC2 CDK4 NOXA1 BACH1 CDK2 BCL2 MDM2 ATM ATR CDKN1A CDKN1B PTEN BRCA1 CASP9 CASP8 CASP3 JAK1 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260610%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells CD40LG PF4 SELPLG IL1B TGFB1 VCAM1 TLR7 TLR4 SELE SELP CCL5 CD40 CCL2 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260610%WP5304%HOMO SAPIENS Cholesterol metabolism NPC2 HSD17B7 DHCR7 CYP27A1 HMGCS1 NPC1L1 FABP2 DKFZp434B2017 CD36 SLC27A4 CYP51A1 STAR SCARB1 LIPG ANGPTL3 MTTP LPA HMGCR LIPC LRPAP1 APOH APOB CIDEB LDLR PLTP FDFT1 DGAT1 APOA2 LBR APOC3 APOA4 SQLE SOAT1 APOC2 APOC1 APOE LIPA PBR ABCG8 ABCG5 FDPS TM7SF2 MVK ABCB11 PMVK DHCR24 MYLIP ACAT2 LPL MGAT1 SORT1 PCSK9 VAPA EBP CYP7A1 ABCA1 STARD3 SC5D MSMO1 MVD NPC1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2858%HOMO SAPIENS Ectoderm differentiation TNFRSF11B BMPR1A FHL2 GAS2L1 SNCA SMURF1 AHI-1 BOC SKIL GLB1 HDAC10 SMAD4 FYN NLK SDCBP CCL2 TNLG7C TFAP2A HMGB2 PDE7A MYC CLDN11 LDB2 FZD8 PRKAG2 CAP2 H2BC9 NLGN1 SOCS2 POU2F2 TBL1X CTNNA2 CDH8 CDH6 PAX3 ROR2 NR1C2 PIM1 BCOR GATA6 OGT TFAP2C SPRY2 CELSR2 ZFHX4 KCNK10 TLE5 MZF1 ASTN1 SCHIP1 LY6E ARX CTNND2 STC1 ARHGAP15 ZBTB2 TRPM2 TCF7L1 RHPN1 JUP ST8SIA4 ZBTB16 HESX1 ZBTB7B MKS1 GREB1 PAN2 PTPRB TOX3 PPFIBP2 MAFB WDR44 FOXA2 SIX6 ARHGDIG UBTF RAB8B FGFR2 BCAS3 ELOVL4 NFATC1 SORCS1 BAZ1A LHX1 FOXL1 SERPINB6 ARHGAP10 KIFC3 PTPN13 RUTBC3 STX16 RRBP1 SOX2 NR2F2 CLVS1 NUMA1 TTC14 C1GALT1 VAX2 RIT1 ZNF219 MYORG PLXNA2 DMD CDON FZD5 RGMA FZD4 GLI3 SHH CTBP1 KRT6A TCF3 NF2 ELOVL2 BMP4 WNT1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260610%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism STAR HSD17B3 POR CYP17A1 H6PD HSD11B1 HSD11B2 SRD5A2 HSD3B2 CYP11B2 CYP21A2 HSD3B1 CYP11A1 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260610%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NOTCH4 NCF1 RBPJ NCF2 NOTCH1 CDC42 DLL4 CYBB DOCK6 MAPK1 CYBC1 NFKB1 CXXC5 CHCHD2 MAPK3 C4orf54 COX4I2 BEND6 EFL1 SHCBP1 ARHGAP31 IBTK EIF6 SBDS KCNN3 NOX3 DGUOK GTF2I BTK SP1 TLR9 TLR8 NCF4 RAC1 CYBA TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260610%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3CA ERBB4 PIK3R4 ERBB3 ERBB2 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3R5 NRAS MAPK1 MAPK3 RAF1 EGFR HRAS PIK3C2G PIK3C2B AKT3 BENZENE METABOLISM%WIKIPATHWAYS_20260610%WP3891%HOMO SAPIENS Benzene metabolism DHDH CYP2E1 EPHX1 NQO1 GSTM1 MPO HEART DEVELOPMENT%WIKIPATHWAYS_20260610%WP1591%HOMO SAPIENS Heart development PITX2 NFATC3 NFATC2 NFATC1 NOTCH1 BMPR1A ERBB3 NKX2-5 GATA4 VEGFB NFATC4 VEGFC MAPK1 BMP10 MEF2C FOXH1 BHLHB2 PTPN11 FOXC1 TBX2 BMPR2 GATA6 TBX1 FGF10 FOXC2 SHH HAND2 SMYD1 FGF8 TBX20 SMAD1 IRX4 TBX5 ISL1 SMAD4 BMP4 BMP2 HAND1 VEGFA FOXA2 HEY2 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP4159%HOMO SAPIENS GABA receptor signaling GABBR1 GABRB3 GABRB2 GAD2 GABRB1 AP2A1 AP2A2 GABBR2 SLC32A1 ALDH9A1 GPHN GABRE ABAT AP2M1 GABRQ GABRA2 GABRP GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SLC6A11 GABRG3 GABRG1 AP2S1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260610%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC5 KAT2B MTR HDAC8 ALDH2 CYP2E1 HEL-S-117 ATF2 HEL-S-53e ACSS2 TYMS ADH1A HDAC10 HAT1 ADH1C ALDH1A3 MAT1A HDAC3 DHFR HDAC2 ELP3 ALDH1A2 SLC19A1 HDAC7 HDAC1 IL19 SIGNALING%WIKIPATHWAYS_20260610%WP5422%HOMO SAPIENS IL19 signaling CCL11 MAPK14 MUC5AC CCNB1 ACTA2 COL1A1 IL4 TGFB1 MAPK8 MAPK1 CXCR4 NFKB1 IL20RA IL20RB SOCS1 MAPK3 SOCS5 IL19 STAT1 JAK1 STAT3 TNF RAC1 TNFRSF1A INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260610%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PKN1 PIK3CA PLCB3 PKN2 PLCB4 TEAD2 TEAD3 TEAD4 PLCB1 PLCB2 PIK3R3 ARHA PIK3R2 PIK3R1 TSC2 TSC1 LATS2 MAPK1 AKT3 MOB1A MTOR ROCK1 PIK3CD LATS1 TRIO YAP1 PKN3 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP PTH1R IHH FGF9 DKFZp686F0183 MAP2K1 MAP2K2 PTHLH MAPK1 MAPK3 RAF1 THRA STAT1 FGFR3 PPP2CA MAPK14 FGF18 NPR2 SNAI1 CDKN1A RBL1 SOX9 MAPK12 MAPK13 MAPK11 BMP4 BMP2 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260610%WP3929%HOMO SAPIENS Chemokine signaling ADRBK1 PLCB3 PLCB4 PLCB1 PLCB2 CXCL9 DKFZp686L0365 CXCL13 CXCL3 GNGT1 CXCL5 GNGT2 CCR6 PRKACG PIK3CD GNAI3 VAV1 GNG3 IL8RB GNG10 JAK3 GNG5 GNG4 CCL5 ITK GNG7 CCL4 CCL3 GNG8 GNG12 GNG11 GNG13 GNB2 GNB1 NCF1 STAT2 GNB5 PPBP CRKL CXCL11 CXCL12 PF4 MAP2K1 SHC2 SHC3 SHC1 LYN RAF1 PXN TIAM1 RAP1A NFKBIA GRB2 CCL17 PIK3R5 GRK1 CCR10 CCR1 XCR1 HRAS RAC1 VAV2 CCR3 PIK3CA SOS1 CRK CDC42 CX3CL1 CCR8 CCR7 PAK1 CCR4 MAPK1 CCR2 CXCR4 PTK2B MAPK3 PARD3 STAT1 STAT3 IKBKB AKT3 GNAI1 CCL11 CXCR5 IKBKG CXCR6 GNB4 CHUK CCL19 SOS2 ADCY3 CCL15 ADCY1 CCL25 ADCY8 RELA CCL24 ADCY6 CCL22 STAT5B ADCY5 CCL21 ADCY9 GNG2 CCL27 CCL26 SHC4 CXCR3 CXCL14 PRKCB WAS CXCL16 WASL PRKCZ GSK3B PIK3R3 PIK3R2 NFKBIB PIK3R1 GRK5 NRAS GRK4 NFKB1 FOXO3A VAV3 XCL1 CX3CR1 ROCK1 PREX1 ROCK2 ELMO1 DOCK2 PRKX CCL7 CCL1 GNB3 CCL20 CCL28 c-fgr CSK FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260610%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes NPC2 MYLIP HEL-S-104 DBI FABP1 SORT1 FABP2 ACSL1 ACSL6 PCSK9 ACSL5 SLC27A4 ACSL3 STAR SCARB1 SLC27A2 LPA APOB LDLR SOAT2 ABCA1 SLC27A3 APOA4 SLC27A1 SOAT1 STARD3 APOC2 APOC1 APOE LIPA FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260610%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA5 LPL APOC2 LIPC LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 APOA4 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260610%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 IRF2 FOXO1 DDX21 NPAS2 CREBBP SMAD4 CREB1 FBL PCNA MAFG HEL23 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling REL EGLN2 IL6 RELB CCND1 MMP2 IL1B VCAM1 MMP3 BIRC5 BCL2L2 SELE CSF2 NFKB1 CXCL8 NFKB2 CXCL2 TNF IKBKB BIRC2 CD40LG BIRC3 CHUK BCL2A1 RELA IL2 TRAF6 IL1A PTGS2 MMP9 VEGFA TNFRSF1A SILDENAFIL TREATMENT%WIKIPATHWAYS_20260610%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1B1 PDE4B PDE4A GUCY1A2 NOS2 PDE5A PDE4D GSK3B HEL-S-162eP NRF1 PARK2 ZNF746 TFAM PPARGC1A PRKG1 AKT3 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260610%WP2003%HOMO SAPIENS miR targeted genes in leukocytes TMEM109 ACP2 SCYL1 HEL-S-47e TUBA1A RFT1 GOLGA7 ATP6V1F PRPF40A PTRH1 YWHAQ GNA13 DNAJB1 PHC2 FADS1 SAC3D1 MENT CDIPT ADPGK TYMS ANAPC1 UNC93B1 POLR2C FMNL2 POLE4 MTHFD2 BCL6 HEL-S-30 MCL1 MAP3K8 SLC7A11 LPL VPS39 RAB5C CAP1 SNAP23 BCL2 CHORDC1 CDK6 CDK5RAP3 ATP6V0E1 IFRD1 PISD GYS1 DCAF7 MRPL20 RDH10 HMOX1 SNX6 ANXA2 PLXND1 SPTLC1 SFXN1 DDX5 ARF4 POM121 TRAM1 MRC2 TMEM43 TMED3 NELFCD HMGA1 CTSC MAPK14 LAMTOR3 SLC7A6 CDCP1 FRG1 PTPA USP1 SHOC2 SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 HEL-S-26 THBS1 TUSC2 TNLG5A ARID4B TXN2 CEBPB HEL-S-66 MPDU1 KCNN4 PPIF PPIB TPM3 TMED10 PNP SLC1A4 ADIPOR2 RTN4 CORO1C CD164 BRPF3 LMNB2 TBCA IGF2R PRSS21 SLC25A1 TNFAIP2 ATP2A2 ADAR SERPINE2 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260610%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM KAT5 RASSF1 CHEK2 CHEK1 H2AX PCNA ATF2 TRIM28 NBN APAF1 MDC1 RIF1 BLM SMC1A PRKDC CDKN2A MRE11A FANCD2 RAD50 BAX MCPH1 RNF8 LATS1 NABP2 RAD52 MDM2 HSF1 RAD51 TRAF6 TP53BP1 CDK5 ATM BAK1 RAD17 TP73 ATR RAD9A BRCA1 YAP1 CASP9 SMC3 CASP3 TERF2 BRCA2 ACTL6A PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260610%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway GDF5 NOTCH1 EPO IL6 NODAL FGF4 EGF WNT2B NOG IGF1 HGF CSF1 IL11 WNT7B ALK PDGFA CXCR1 IL6R FGF10 KIT CSF1R SHH TF INS FGF8 FLT3LG TPO WNT3A CNTF TGFB1 NT5E FST LEFTY1 IL3 DKK1 BMP4 FGF2 NTF4 WNT1 INHBA VEGFA TNFSF11 KITLG LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma MDH2 SLC19A2 NMRK2 CS FH NONO MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260610%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 CHI3L1 IL6ST BAX SOCS3 MYC MMP9 STAT3 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260610%WP3877%HOMO SAPIENS MYD88 distinct input output pathway MYD88 JUN TLR9 TLR8 TLR5 TRAF6 TLR10 TLR7 TLR4 HEL-S-71 NFKB1 TIFA UBE2V1 TLR1 IL1A IRAK1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260610%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma PINK1 HMGB1 AGER SQSTM1 MDM2 PARK2 VMP1 DKFZp762B153 IPO8 NFE2L2 SHOC2 NFKB1 TFEB STAT3 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5402%HOMO SAPIENS 10q22q23 copy number variation SHLD3 LRIT1 PRXL2A SHLD2 ERBB4 SHLD1 BMPR1A SH3GL3 CCSER2 OPN4 ROPN1L RSPH6A DYDC1 CEBPA MAD2L2 RSPH14 NRG3 MAT1A IQUB RSPH9 ADAM10 NME5 VEGFA RSPH3 STAG1 BUB1B RSPH1 GLUD1 NFKB1 PPARG SMC1A MMRN2 ZMYND11 PDS5B PDS5A ACTN2 WAPAL SIRT4 SH2D4B FAM25A DNAJB13 ADIRF LDB3 GHITM CDHR1 SMC3 DYDC2 RGR GPR15LG BMP2 SNCG RAD21 SUSD2 MAS1 TSPAN14 TNFSF11 LRIT2 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260610%WP5275%HOMO SAPIENS Ether lipid biosynthesis GNPAT LPCAT1 LPIN2 PEX16 PEDS1 CEPT1 LPIN3 ALDH3A2 PEX7 PEX5L DHRS7B AGMO ACAD10 PEX19 UGT8 PEX3 LPIN1 FAR1 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260610%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus SPHK1 SGMS2 SGPP1 B3GALT2 UGCG B3GALT1 SGPP2 KDSR CERS3 CERK GALNT16 SGMS1 B4GALT2 UGT8 B4GALT1 B4GALNT1 SGPL1 SPHK2 GALNT1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260610%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL10RB STAT2 IL10RA HMOX1 IL6 HEL-S-10 IL10 IL1A STAT1 JAK1 STAT3 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260610%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness TNNC1 PLCG1 JUN MAPK1 PRKCQ MFAP5 ITGB3 MAPK3 ITGAV CREB1 RYR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260610%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCG1 PKD1 PLCE1 PLCB3 GNA11 PLCH1 FFAR1 PLCG2 PLCD3 PLCB1 PLCB2 PLCL1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260610%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome PAXIP1 RAD50 BRCA1 RAD18 NBN SMC3 MDC1 SMC1A RAD21 MRE11A ATM FRAGILE X SYNDROME%WIKIPATHWAYS_20260610%WP4549%HOMO SAPIENS Fragile X syndrome CAMK2A SH3GL3 SOS1 TTI1 ALDH3A2 PRKAR1A CREB1 AGAP2 PLCB1 SYNGAP1 DEPTOR DKFZp762B153 ABCD3 KCNC1 SH3GL1 KCND2 GRIP2 AKT1S1 TBC1D7 MAPK1 EIF4EBP2 EPS8L1 ARHGAP32 ARAF CNR1 CDKN2A SHANK1 PTPN11 MTOR ALDH5A1 EIF4A1 ABAT AP2M1 EPHA4 PPP2R5B GRIA2 AP2S1 HCN1 SRC FYN EIF4E MMP9 HOMER1 RPS6KB1 PLCG1 GRIN2B CYFIP1 FMR1 DLG4 PRKCA GABRB2 APP PPP3CA ARC MAP1B AP2A1 MAP2K1 NF1 DUSP3 EIF4G1 MAP2K2 SHC1 CPT1A TSC2 TSC1 MLST8 DLGAP3 RAF1 EEF1A1 NTRK2 PICK1 AKAP5 CAMK1 DAG1 PTPN5 CLTCL1 GPHN DICER1 RHEB GRIP1 GRB2 CYFIP2 GAD1 CLTC CLTB PTEN CLTA GRIN1 CAMK4 RPTOR RAP1GAP TARBP2 BDNF AGO2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP4149%HOMO SAPIENS White fat cell differentiation IRF4 NR3C1 KLF2 KLF4 CREB1 RORA ZNF423 NR2F2 CTNNA1 CEBPB FOXO1 CEBPD EVI1 TLE3 PPARG WNT10B GATA2 GATA3 CEBPA INS EGR2 IRF3 STAT5B KLF15 TCF7L1 NR1H3 DDIT3 KLF5 RARA POLYOL PATHWAY%WIKIPATHWAYS_20260610%WP690%HOMO SAPIENS Polyol pathway SORD AKR1B1 KHK ALDOB STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260610%WP4463%HOMO SAPIENS Steroidogenic pathway STAR HSD17B1 HSD3B1 CYP17A1 CYP11A1 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260610%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 LIPG MTTP ANXA2 LIPC APOB LDLR ABCA1 APOA2 LPL APOC2 APOE PCSK9 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260610%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma ARID1A PIK3CA NOTCH1 MYB MAML3 UHRF1 SETD2 JMJD1C NCOR1 HIST1H1E CMTR2 ARID5B SMARCE1 NFIB MAGI1 HIST1H2AK INSRR FOXP2 BCOR MORF4L1 BCORL1 KMT2C KAT6A MYCBP EP300 SRCAP DTX4 MGA KANSL1 CEBPA CREBBP FGFR4 MYBL1 FGF16 ERBB2 ARID4B CHEK2 MYC CHEK1 MAP2K2 ERBIN TLK1 FOXO3A RAF1 SMC1A PRKDC CTBP1 KDM6B ATM FBXW7 PTEN BRCA1 HRAS MAX WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260610%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP5 CREBBP LRP6 PORCN ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260610%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE PDHA1 ChAT PEMT PDHA2 CHKA GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260610%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGKZ GPAM AGPAT4 PTDSS1 GPAT4 PEMT CDS1 CHKB PCYT2 PTDSS2 PNPLA2 CRLS1 DGAT1 CHPT1 PLA2G1B PISD PNPLA3 CDIPT DGAT2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260610%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD ATR SIGNALING%WIKIPATHWAYS_20260610%WP3875%HOMO SAPIENS ATR signaling TOPBP1 ATR RAD1 RAD9A HUS1 ATRIP RPA1 RPA3 RAD9B CHEK1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260610%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation CD34 CSF3 NCKAP1L NOTCH1 EPO MYB IL1B GP9 LYL1 ACVR1B CSF2 CSF1 CXCR4 SPI1 MHC2TA PIM1 KLF1 MUC1 RUNX1 ITGA2B TRAF3IP3 IKZF1 HMGN5 LEF1 TRIM29 TPO CBFA2T3 ZNF835 VAV1 ABO MXI1 NFE2 RIOK3 FLI1 IL3 FOSB NFATC2 IL6 ARHH HES6 LMO2 GATA1 GATA2 IL5 NR1A2 XB ITGB3 IL1A FOS KITLG FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260610%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 ANGPTL3 LIPC LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 APOA4 APOA5 LPL APOC2 ANGPTL4 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260610%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 CYP4F3 FADS2 ACSL1 CANCER PATHWAYS%WIKIPATHWAYS_20260610%WP5434%HOMO SAPIENS Cancer pathways RARB HES5 RPS6KA5 GNAS VEGFB VEGFC HES1 DCC CXCL8 CAMK2D GNGT1 GNGT2 GSTT2 PRKACG EP300 IL6R IFNAR2 ARHGEF1 TRAF2 TRAF3 TRAF6 TRAF5 GNAI3 IFNAR1 HDAC2 GNG3 GNG10 GNG5 GNG4 GNG7 GNG8 GNG12 FADD GNG11 HEY2 GNG13 GNB2 SKP1 GNB1 STAT2 GNB5 IL6 CXCL12 TGFA IL13RA1 ALK KPG_010 POLK EML4 PDGFA LPAR2 LPAR3 RXRB IGF2 RXRG IFNA5 IFNA4 IFNA7 IL4 NFKBIA IFNA6 IFNA1 IFNA2 IFNA8 ITGAV RAC1 KITLG ITGA6 CSF3R EPO IFNA13 IFNA14 IFNA16 IFNA17 ARHA COL4A3 COL4A5 IFNA10 CXCR4 IFNA21 EGFR ARNT2 IL7 GNB4 IL7R ITGA2B HSP90AB1 FLT4 IL3RA COL4A2 MSH3 COL4A1 GNG2 COL4A4 COL4A6 LAMB4 EPOR PRKCB RBX1 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B WNT9B PIK3R1 WNT9A FOXO1 NRAS LAMC2 WNT16 WNT8A LAMC1 WNT8B RAC3 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FZD4 WNT7B FZD9 BIRC2 WNT7A BIRC3 LAMA5 ROCK1 CAMK2G LAMA1 ROCK2 LAMA4 LAMA3 FRAT1 CTBP1 LAMB3 LAMB2 LAMB1 VEGFD KNG1 BDKRB2 LPAR4 BDKRB1 JAG2 NOTCH1 LPAR1 AXIN2 DLL3 DLL4 IL23A PTCH1 BCL2L11 PIK3CD CKS1B IL2 CBL FH STAT4 RPS6KB1 SKP2 BBC3 CCDC42 E2F2 CCND3 CCND2 MGST3 MGST2 APAF1 CCDC6 DDB2 CCNE2 CCNE1 GSTM5 PMAIP1 GADD45B GADD45A PML MGST1 GADD45G CDK6 RAD51 CYCS GSTA5 F2R GSTA4 GSTA3 F2 IFNG PAX8 NCOA1 RXRA SPI1 FLT3 ARAF NR1C2 IKBKB AKT3 PIM1 PIM2 IKBKG CHUK RUNX1 CCNA2 KIT SOS2 CEBPA CSF1R LEF1 RELA RUNX1T1 STAT5B TCF7L2 TCF7L1 JUP ZBTB16 IL3 RPS6KB2 BRCA2 IGF1R PRKCA ERBB2 PLCG2 FGFR1 NFE2L2 PPARG IL5RA IL2RG IL5 IL2RA IL2RB NOS2 IL12B IL12A IL13 TNFSF6 MAX MAPK10 PLCB3 PLCB4 PLCB1 PLCB2 ITGB1 ITGA2 EVI1 TRAF1 IL6ST TFG PLEKHG5 JAK3 HHIP EDNRA EDNRB SMAD4 ARHGEF11 RASGRP4 RASGRP3 BCL2L1 MMP3 TGFBR1 MAPK9 FRAT2 Em:AP000351.3 IL15RA GSTM1 HMOX1 GSTM4 CTNNA1 CTNNA3 CTNNA2 CTBP2 PTGER1 PTGER2 IFNGR1 PTGER3 IFNGR2 DVL3 CALML6 CALML3 CALML4 IL12RB1 TPR CSF2RB CSF2RA NOTCH2 AGTR1 F2RL3 RALB DVL1 HDAC1 FZD2 CAMK2A SUFU EGLN3 PTCH2 TGFBR2 EGLN2 KIF7 ELOC BIRC7 GNA13 E2F3 APC WNT3A VHL NTRK1 FGFR4 RB1 CRKL CCND1 ARHGEF12 MYC MAP2K1 MAP2K2 GSTM2 HGF FZD7 MSH6 AXIN1 MSH2 FZD8 RAF1 DVL2 KLK3 SMAD2 JUN GNA11 CDK4 SP1 CDK2 BCL2 MDM2 HEL-S-21 GRB2 CDKN1A LRP5 CDKN1B PTEN LRP6 CASP9 CASP8 CASP3 HEL-S-125m APPL1 HRAS JAK1 FZD1 FOS NOTCH3 NOTCH4 PIK3CA SOS1 NQO1 CRK KEAP1 BCR MAPK8 MAPK1 MAPK3 CDKN2B BAD STAT1 CDKN2A STAT3 GNAI1 MTOR TERT BAX ADCY3 ADCY1 RALBP1 FLT3LG ADCY8 ADCY6 PLD2 ADCY5 ADCY9 PDGFRA RALA CREBBP EDN1 TXNRD2 HIF1A VEGFA PLCG1 FGFR2 APC2 RASSF1 EGF MMP2 DAPK2 IGF1 BIRC5 NFKB1 NFKB2 NR3A2 GSTM3 TPM3 FGFR3 RET HEL-S-22 GLI3 SHH GNB3 TGFB1 BAK1 EGLN1 TRAF4 NKX3-1 PTGER4 BMP4 BMP2 PTGS2 WNT1 SMO RARA RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260610%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MTOR PIK3CA PTEN RPL11 RICTOR MLST8 FOXO3A EGFR RIOK2 RIOK1 MAPKAP1 AKT3 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260610%WP691%HOMO SAPIENS Tamoxifen metabolism CYP1A2 UGT1A4 CYP1A1 UGT2B7 CYP1B1 UGT1A8 CYP3A4 UGT1A10 CYP2C19 CYP2C9 CYP2A6 CYP2E1 SULT1A1 SULT1E1 SULT2A1 UGT2B15 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260610%WP5174%HOMO SAPIENS Ulcerative colitis signaling IL5 NFATC1 GATA3 IL10 HLA-DMA MAF IL4 TGFB1 IL13 FOXP3 NFKB1 NOD2 IFNG IL2RG TNF OXYTOCIN SIGNALING%WIKIPATHWAYS_20260610%WP2889%HOMO SAPIENS Oxytocin signaling OXTR BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260610%WP272%HOMO SAPIENS Blood clotting cascade F10 SERPINB2 PLAT F3 F13B FGA F7 F11 PLG SERPINF2 F2 KLK1 HEL-S-78p F5 VWF F8 F9 KLKB1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260610%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling DDIT4 EGR1 NEK9 CXCL6 CXCL9 IFITM1 CXCL8 TLE3 CXCL1 CXCL13 CXCL3 CXCL2 TNF CXCL5 CCR6 TBK1 IL10 TRAF2 ACE2 IL1R2 IRF3 IFIH1 APOA2 TRAF3 RRM2 TRAF6 APOC1 IL8RB IL9 LARP1 CCL5 CCL4 CCL3 CCL2 IFITM3 HEL117 GTSE1 VPS36 IFNB1 WDR74 IFI27 CD226 MX1 APOM ITCH HEL103 MAVS HRG IL6 CTSZ SERPINA10 TP53I3 EIF4A2 MMP25 SDF2 CXCL12 IL16 RIGI HMFT1766 PF4 OS9 SRP19 HP CLCC1 GTF2F2 HEL-S-72p UGCGL2 G3BP2 NPTX1 VPS18 MDN1 GABARAPL2 TRO VPS33A TRIM59 ITIH3 ATE1 RPS6 TBKBP1 ATP13A3 FAM98A INTS4 VPS16 HLA-DRB5 ITIH4 BST2 IL4 TNFSF10 HLA-DRB1 MIB1 CTSL C1QBP RAC1 IL22 MOV10 IL1B DKFZp762B153 CCR5 VPS41 GP1BA LGALS3BP RRAS CCL11 IL7 CXCR1 CCL15 IL33 CCL22 CCL21 PRG3 CCL27 CCL26 IL-21 CXCL16 IL18RAP DKFZp781O1323 IFI6 LBP APOL1 MLST8 COQ8B HEL-S-81p ULK1 HBD CCL8 RTN4 CCL1 FAM83A C1S CFP C8A CFB TGFBR2 CFH CFI SRP54 PIAS1 ZAP70 LCK JUNB IRF9 OAS2 NTRK1 FYN EIF4E PTPN6 TOMM70 CARD11 FGA HEL-S-78p ALB SAA1 SAA2 EIF4EBP1 CCNB2 JUN CCNB1 CDC2 RHEB AHR NRF CD2 RPTOR IL18 CASP9 CASP8 CASP3 JAK1 IRAK1 IFNG PARP2 NLRP3 FOS GGH MYD88 IFIT1 CD163 DEPTOR CPN1 MAPK8 AKT1S1 STAT1 CRP IKBKG MTOR PMPCB APOH STEAP3 TPO CD14 TRPM2 PITRM1 SMAD1 FGF2 HIF1A ADAM9 NFATC3 APOD CD3G PRKCQ CD3E IGLL1 CD8B CD8A HEL-S-130P NLRP1 BIRC5 CEBPB SELP NFKB2 IL5 HBB TF IL12A ACTG1 CASP5 CCL20 PS1TP5BP1 IL13 CAMK4 IL17A IL1A PTGS2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260610%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis TEAD2 SPARC PBX3 TEAD3 TEAD4 THBS2 COL1A1 SNAI2 YAP1 TWIST1 EDNRA GPC6 COL3A1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260610%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGA6 ITGA1 DSG2 ITGB1 CTNNA1 CTNNA3 CTNNA2 ITGA4 ITGA2 ITGB7 RYR2 ITGA2B GJA1 CDH2 CACNA2D3 LEF1 CACNA2D2 CACNA2D4 EMD CACNB1 TCF7L2 SGCA CACNB3 TCF7L1 CACNB4 JUP DSC2 CACNA1F CACNA1S PKP2 SLC8A1 ITGB4 ITGB8 ACTN1 ITGB6 CACNG6 CACNG7 DMD CACNG1 CACNG3 CACNA1C CACNG4 ACTN2 ITGA7 CACNG5 DAG1 CACNG8 ACTN4 DES CACNG2 SGCD SGCB SGCG ACTG1 PS1TP5BP1 LMNA CACNA2D1 ITGB3 ITGAV ATP2A2 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260610%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260610%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders F10 F7 OTC ASL NAGS GPT HEL-S-20 ASS1 ARG1 GLS2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260610%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX7A2 COX5A COX3 SURF1 COX19 COX16 COX18 TACO1 COX7B HIGD1A PET117 COX14 COA6 COX10 COX6A1 COX2 PET100 COX7C COX1 FAM36A CMC1 TMEM177 PNKD COA3 SMIM20 COX17 COX8A COXFA4 COX11 COX6B1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260610%WP3407%HOMO SAPIENS FTO obesity variant mechanism UCP1 TBX1 PPARGC1A PRDM16 IRX5 IRX3 ARID5B CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260610%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling MAPK14 BMP1 SMAD2 BMPR2 TGFBR2 BMPR1A LOXL1 MAPK9 LOXL2 TGFB1 GREM1 MAPK8 TGFBR1 SMAD4 LOXL4 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260610%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNB1 GOT2 HAAO IL6 TDO2 DDC AFMID AHR KYAT3 KYAT1 IDO2 IL1B IFNA6 KYNU KMO AADAT IFNG TNF IDO1 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260610%WP5461%HOMO SAPIENS Primary ovarian insufficiency BMPR1A SALL4 DAZL GNAS FOXL2 NR5A1 WT1 SOX8 FIGLA DMC1 MST1R ZP3 STAR ALOX12 POLR2C RECQL4 WRN TP63 FANCA RFWD3 ERAL1 POLR3H ZAR1 FSHR NUP107 PPM1B NBN BLM COX10 LARS2 STAG3 RAD51 ATM PRORP ANTXR1 MEIOSIN POF1B MEIOB SIL1 NANOS3 PREPL NOBOX AARS2 AIRE HMMR WDR62 SYCE1 SOHLH1 KASH5 TGFBR3 SOHLH2 SLX4 SWI5 HELQ DIAPH2 H1-8 HROB LHX8 MCMDC2 ELAVL2 BNC1 EIF2B1 C1orf146 DCAF17 MRPS22 SPIDR HSD17B4 SIX6OS1 HAX1 CYP17A1 PCCA PCCB PSMC3IP HSD17B1 CCDC185 EIF2B2 MGME1 C10orf2 MND1 NLRP11 XPNPEP2 SPATA33 FANCM FANCL CLPP PGRMC1 AMHR2 BRCA2 FMR1 MCM9 CENPE EIF4ENIF1 ATG9A BMP6 LAMC1 NR3A2 BMP15 AMH POLG NOTCH2 BMPR2 KHDRBS1 LMNA MSH4 MSH5 EIF2B5 STRA8 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260610%WP4537%HOMO SAPIENS Hippo YAP signaling WWTR1 MAP4K2 MINK1 TEAD2 RASSF1 TEAD3 TEAD4 LATS1 MAP4K3 LATS2 NF2 YAP1 TNIK MAP4K1 HEL-S-31 STK38L GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism B4GALNT1 NEU4 HEL-S-111 ST8SIA1 HEXA B3GALT4 ST8SIA5 NEU3 ST3GAL5 ST8SIA6 SIAT4C ST3GAL1 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260610%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction IFNA1 IFNAR1 NFKB1 ACE2 TNF TNFRSF1A ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260610%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism HSD17B8 CYP1A2 CYP3A7 UGT2A2 UGT2B7 CYP1B1 UGT1A8 CYP3A4 HSD17B3 HSD17B4 UGT1A10 HSD17B7 CYP2C19 CYP2C9 HSD17B1 HSD17B2 HSD17B10 SULT1E1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism ACLY MTTP ACADM SLC2A4 APOB PPARGC1B NR1C1 ESRRA HADHB STK11 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260610%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260610%WP2363%HOMO SAPIENS Gastric cancer network 2 DGIC TOP2A RFC3 RFC4 MYC S100A6 UBE2C OTUD5 CEBPZ EGFR CHTF18 DSCC1 CHTF8 BRIX1 ATAD2 AHCTF1 CACYBP FAM91A1 RNF144B CD48 COL9A1 COL9A3 UBE2T LMNB2 LBR MTDH RAD17 SNURF DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260610%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260610%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP1A2 RARB NR1i1 ABCC3 ABCB4 CYP3A4 NR1I3 ABCC2 ABCB1 CYP8B1 ABCG5 NR1i2 NR1H4 ABCG1 ABCB11 CYP2C9 ABCD3 CYP2E1 CYP2B6 CYP27B1 CYP24A1 PPARG NR1C2 CYP26A1 ABCD2 CYP7A1 ABCA1 NR1H3 NR1B3 CYP4A11 NR1C1 RARA ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260610%WP4298%HOMO SAPIENS Acute viral myocarditis CASP2 CCR3 SOS1 HLA-DMA CREB1 HEL-S-28 MICA CCR5 MAPK1 CXCR4 MAPK3 STAT1 TNF STAT3 BAX IL10 CAAP1 CXADR CHRAC1 BNIP2 IL2 SGCA NOD2 SOCS1 EDN1 SRC FYN MMP9 BCL2L1 IL6 CCND1 GSK3B EIF4G1 PYCARD PABPC1 PIK3R1 TLR4 NFKB2 RAC3 DMD CD80 DAG1 CD40LG AIF1 AAG1 TICAM1 SGCD MYH6 SGCB IL12B IL12A SGCG TLR5 BCL2 TLR3 CASP6 PS1TP5BP1 ABL2 TGFB1 CYCS DFFB CASP9 DFFA CASP8 CASP3 CD55 JAK1 IFNG FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260610%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH9A1 CS ALDH3A2 ALDH2 ACSS2 ACO2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260610%WP4752%HOMO SAPIENS Base excision repair SMUG1 LIG1 RFC2 POLE RFC3 RFC4 PCNA TDG NEIL2 POLG POLL RFC1 FEN1 POLD3 POLD4 POLD2 HMGB1 PARP4 APTX APEX1 MPG OGG1 PNKP UNG POLE4 NTHL1 MUTYH MBD4 PARP3 ADPRHL2 NEIL3 POLG2 TDP1 NEIL1 POLE2 POLE3 PARP2 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260610%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADVL ACSF2 CPT2 ACADL EHHADH SLC25A20 ACADS CPT1A ACADM PECR ACSL1 FACL4 ACSL3 RAS SIGNALING%WIKIPATHWAYS_20260610%WP4223%HOMO SAPIENS Ras signaling MAPK10 HTR7 GNGT1 GNGT2 PLA2G4B ARF6 PRKACG PLA2G5 PIK3CD GAB2 ZAP70 GNG3 GNG10 GNG5 NTRK1 GNG4 STK4 GNG7 GNG8 RASGRP4 GNG12 RASGRP3 GNG11 GNG13 BCL2L1 FGFR4 GRIN2B GNB2 REL KSR2 GNB1 GNB5 RASGRF2 PLA1A MAP2K1 PLA2G4F AFDN MAP2K2 SHC2 PLA2G4D SHC3 LAT PLA2G4E SHC1 PLA2G4C RRAS2 KSR1 PLA2G1B RAF1 NTRK2 RAB5B TIAM1 RAB5C RAP1A PLCE1 EPHA2 MAPK9 GRB2 ABL2 CALM1 RAB5A GRIN1 NGFR HRAS RAC1 RASA2 PIK3CA SOS1 PLA2G6 CDC42 SYNGAP1 ARHA MAPK8 PAK1 RAPGEF5 MAPK1 MAPK3 FLT3 EGFR BAD IKBKB CALML6 AKT3 RRAS CALML3 PTPN11 CALML4 RASA3 IKBKG GNB4 CHUK KIT FLT4 SOS2 CSF1R RALBP1 RIN1 RELA PLD2 PDGFRA RALA SHOC2 GNG2 FLT1 PLA2G3 RASAL1 SHC4 RASAL3 IGF1R TTBK1 KDR RGL2 PLA2G12A PRKCB PLCG1 RASA4B FGFR2 PLA2G12B PLAAT3 RASA4 PRKCA PLA2G2F PLA2G2D PLA2G2E RASSF1 PLA2G2C PLCG2 NF1 FGFR1 PIK3R3 PIK3R2 ETS2 FOXO4 PIK3R1 RASGRF1 NRAS INSR NFKB1 RAC3 FGFR3 PAK6 PAK4 GNB3 EXOC2 RALB PLA2G10 TNFSF6 PLA2G2A LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260610%WP3935%HOMO SAPIENS Leptin insulin signaling overlap IRS4 DGKZ PDPK1 IRS1 INS PIK3R3 INSR SOCS3 SOCS1 LEP STAT3 SOCS2 LEPR DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260610%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DDX1 DGCR8 DROSHA NBN MRE11A ATM GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260610%WP4830%HOMO SAPIENS GDNF RET signaling axis SOX11 LHX1 TCF2 HOXC11 ROBO2 ROBO1 WT1 RET FOXC1 GATA3 HOXD11 SLIT2 GLI3 SPRY1 HOXA11 FOXC2 FAT4 SALL1 SIX2 GREM1 SOX17 EYA1 AGTR2 PAX2 ALDH1A2 BMP4 IFT27 IFT25 GDNF GPCRS OTHER%WIKIPATHWAYS_20260610%WP117%HOMO SAPIENS GPCRs other UTS2R HTR7 CCR5 C5AR2 CCR2 CCKBR CNR1 CXCR1 S1PR1 ADRA1D CELSR2 ADRB2 IL8RB EDNRA ALG6 CXCR3 HTR2A OR1G1 FSHR CHRM2 OR2M4 GPR61 GPR62 GRPR CELSR3 RXFP3 GPR176 GPR132 GNRHR GPR135 ADGRV1 GHRHR OR1F1 OR2H1 TAAR5 OR1J2 TAAR2 HTR1F ADGRL2 OR1N1 ADGRL3 GPR162 OR1R1 OR5AC2 ADGRF5 GPR83 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 CELSR1 OR8G1 OR1E1 GPR88 GPR84 MCHR2 OR2B6 NTSR1 OR5D3 GPR183 P2RY13 GPR17 OR2F1 P2RY11 GPR55 CHRM3 EMR3 ADGRD1 GPR143 OR2A5 LGR6 F2R OR2A4 GPR18 DRD3 OR7E24 ADORA2A DRD4 SSTR2 PTGFR SMO INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260610%WP4558%HOMO SAPIENS Interferon mediated signaling IFNB1 IFNLR1 STAT2 PIK3CA PRKCA IFNA13 IFNA14 IFNA16 IFNA17 IFNW1 PIK3R1 IFNA10 IFNGR1 IFNA21 IFNGR2 STAT1 IFNK IFNL2 IFNL1 IFNAR2 IFNL3 IFNA5 IFNA4 IFNA7 TYK2 IFNA6 IFNA1 IFNA2 IFNA8 IL10RB IFNAR1 IRF9 IFNL4 IFNE JAK1 IFNG ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP138%HOMO SAPIENS Androgen receptor signaling KAT2B RNF6 KAT5 RNF4 BAG1 PATZ1 FHL2 TGFB1I1 CDC42 NCOA1 CREB1 FLNA ARHA SIN3A PSMC3IP UBE2I NCOR2 NCOR1 EGFR SMARCE1 STAT3 NR0B2 NR2C2 EP300 RAN TLE5 RELA PIAS1 ZMIZ1 HEL-S-99n CREBBP LIMK2 SRC SMAD4 RUNX2 TGIF1 SIRT1 CARM1 RB1 CCND1 GSK3B PIK3R2 PIK3R1 FOXO1 SUMO1 RLN1 UBE3A CCNE1 ROCK1 JUN ROCK2 SP1 KDM1A HEL-S-67p PAK6 MDM2 RAD9A PTEN BRCA1 ETV5 EFCAB6 STUB1 HEL32 KAT7 HDAC1 PIAS2 RHOB RAC1 ZNF318 SMIM40 FKBP4 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260610%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways BMPR1A NOG SMAD6 APC IL6ST SELENOP PIK3CD FGF8 MAP2K3 WNT3A SMAD4 MAP2K6 FGFR4 FGF16 MAP2K1 MAP2K2 FZD7 AXIN1 FZD8 RAF1 DVL2 PDGFA JUN FGF13 MDM2 GRB2 FGF12 MAPK7 MAPK6 ERAS MAPK4 ACTR2 LRP5 ACVR1 PTEN MAPK12 LRP6 HRAS JAK1 FZD1 LIF FOS SOS1 FGF3 FGF4 FGF6 FGF7 FGF9 HNF1A MAPK1 FGF20 FGF22 FGF21 FGF17 EGFR ARAF DVL3 STAT3 FGF14 AKT3 PTPN11 FGF19 FGF18 MTOR FGF10 PDGFRA SMAD1 FGF2 FGFR2 SMAD9 EGF MAP2K5 DKFZp781O1323 FGFR1 GSK3B WNT2B PIK3R2 WNT5B WNT9B WNT16 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FGF23 FZD4 WNT7B FZD9 FGFR3 WNT7A BMPR2 ACVR2B BMP4 DVL1 WNT1 FZD2 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260610%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases CEBPB BACE1 APP BDNF SRPK2 SET NTRK2 STAT1 TARDBP SNCA AKT3 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP4970%HOMO SAPIENS Galanin receptor pathway CRP IL6 POMC BCL2L11 CDKN1C CREB1 INS VAMP2 CDKN1A CDKN1B YAP1 SLC2A4 PPARG VEGFA FOS COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260610%WP4478%HOMO SAPIENS LTF danger signal response pathway IFNB1 MYD88 IL6 IRAK4 AGER HEL110 IL1B TRAF6 CD14 IFNA1 TLR4 MAPK1 NFKB1 CXCL8 TREM1 IL1A IRAK1 TNF HINT1 PATHWAY%WIKIPATHWAYS_20260610%WP5523%HOMO SAPIENS HINT1 pathway GTF2H2C_2 CDK7 NFATC2 SH3RF1 JUN GTF2H2 KARS1 GTF2H3 GTF2H4 HINT1 GTF2H5 RUVBL2 ERCC2 MAPK9 MNAT1 NFKB1 USF2 RUVBL1 CCNH TCF4 FOS EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260610%WP405%HOMO SAPIENS Eukaryotic transcription initiation GTF2H2C_2 TBP POLR3H CDK7 POLR3K GTF2H2 TAF9 GTF2H3 GTF2E2 GTF2H4 GTF2E1 TAF12 HEL-S-28 ERCC2 TAF7 MNAT1 TAF6 POLR1A GTF2F2 POLR1D TAF5 POLR2A POLR2B POLR2C POLR2G POLR2H POLR2I POLR2J POLR2K POLR2F GTF2B POLR3B TAF13 POLR3D CCNH POLR3E GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260610%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p GGCT GCLC OPLAH 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260610%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260610%WP5351%HOMO SAPIENS Kleefstra syndrome ARID1A KMT2C ARID1B PAGR1 BAP1 SMARCA4 EHMT1 WDR5 SMARCD1 SMARCD2 SMARCD3 NCOA6 NR1I3 DPY30 MBD5 SMARCC1 SMARCC2 PAXIP1 H3F3B RXRA ASH2L ASXL1 ACTL6B ACTL6A OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260610%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNP MOG MYT1 NKX2-6 SOX6 SOX5 OMG OLIG2 IL1B SOX10 IGF1 ASCL1 CXCL1 SOX8 CXCL2 TNF MBP NKX2-2 SHH CNTF SOX9 BMP4 FGF2 BMP2 LIF OLIG1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260610%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260610%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome GJA8 CHD1L GJA1 PRKAA2 PYGO1 GJA5 PRKAB2 NBPF12 PRKAB1 AFDN BCL9 F11R FMO5 PYGO2 PRKAA1 ACP6 AMELX TJP3 TJP1 PRKAG1 GJA3 PRKAG2 PRKAG3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260610%WP455%HOMO SAPIENS GPCRs class A rhodopsin like OPRK1 HCRTR2 HCRTR1 HTR4 HTR6 HTR7 DRD2 MAS1L LHCGR CCR6 IL8RB EDNRA EDNRB F2RL1 FSHR GPER DRD1 HTR1E HTR1F HTR1D HTR1B GHSR MC4R GPR83 KPG_010 CCR10 CCR1 XCR1 PTGFR PTGDR2 NPY2R TBXA2R PTGDR PTGIR CHRM1 OPN4 OPN3 ADRB3 CCR8 CCR7 CCR5 FFAR3 CCR4 CCR2 MC3R CXCR4 FPR1 PTGER1 PTGER2 PTGER3 CXCR5 HRH3 CXCR1 HTR2B HRH1 HRH2 DRD5 HTR5A ACKR3 GPR37 CXCR3 HTR1A HTR2A ADRA1A OXTR OR1G1 GRPR OR1F1 OR2H1 GPR87 OR3A3 CX3CR1 OR10A5 OR3A1 OR1E1 OR2B6 NTSR1 GPR17 GPR50 CNR2 OR2F1 ACKR4 AGTR1 CHRM3 AGTR2 CHRM4 F2RL3 CHRM5 OR2A4 GPR18 P2RY6 P2RY4 ADORA2A ADORA2B P2RY2 BDKRB2 P2RY1 LPAR4 BDKRB1 LTB4R C3AR1 OPN1SW OPN1MW OPN1LW RHO NPFFR2 C5AR2 RRH GPR174 GPR173 GPR171 CMKLR2 GPR37L1 FPRL2 TRHR OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 NTSR2 OR2J3 OR2J2 OR2J1 MC1R RGL4 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR FFAR2 GPR39 OR5F1 GPR34 GPR32 GPR31 AVPR1A OR5V1 OR3A2 OPRD1 OR10H1 OR10H3 GPR45 CCRL2 OR10H2 GPR42 OR2AG1 CHML GPR52 GPR4 GPR3 GPR6 MC5R OR1C1 GPR65 GPR63 OR2D2 NPY1R OR2T1 OR1A2 KPG_011 OR1A1 OR2C1 SUCNR1 OR5I1 MCHR1 OR2S2 HCAR3 FFAR1 OR1Q1 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 OR7A10 OR14J1 MLNR PRLHR OR8D2 OR7A17 NPY5R OR2H2 AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 OR1E2 NPY4R OR8B8 OR2W1 OR12D3 OR1D5 OR1D2 OR2F2 F2R ACKR2 FPR2 OR11A1 CMKLR1 AVPR1B DRD3 DRD4 F2RL2 MAS1 CCR3 NMBR CCKBR CNR1 GPR85 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A MTNR1A MTNR1B CHRM2 GPR75 ADRA1B P2RY13 P2RY10 P2RY11 P2RY14 PTGER4 GPR161 SSTR2 NPFFR1 GPR68 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260610%WP5193%HOMO SAPIENS Cholesterol synthesis disorders CYP51A1 HMGCR EBP FDFT1 FDPS MVK DHCR24 PMVK DHCR7 LBR SQLE HMGCS1 SC5D MSMO1 HSD3B2 MVD HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260610%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAP2K4 MAPK10 IFI27 RPS6KA2 RPS6KA1 IFITM2 MAP2K1 MAP2K2 MAPK8 IFITM1 MAPK1 MAP3K10 MAPK3 ATF2 MAP3K11 RAF1 MAPK14 JUN MAP2K3 BCL2 MAPK9 BST2 JUNB DDIT3 MAPK12 MAPK13 MAPK11 EIF4E MAP2K6 IFITM3 MAP3K1 FOS TRANSLATION FACTORS%WIKIPATHWAYS_20260610%WP107%HOMO SAPIENS Translation factors EIF2AK1 EIF1AX SUI1 PAIP1 EIF5 EIF2S3 EIF4A2 EIF2B1 EIF3S2 EEF2K EIF3J EIF3G EIF3CL EIF2S2 EEF2 EIF3E EIF4G1 EIF3B PABPC1 EIF2B2 EIF4EBP2 EIF5B EEF1A1 EIF3S3 EIF6 EIF4EBP1 EIF3F EIF3D EIF4A1 EIF3A EIF5A EIF2AK2 EIF2S1 GSPT2 EEF1B2 EIF4H EIF4EBP3 EIF4E EIF2B3 EIF4B CLUH EIF1AY EIF2B5 EEF1G EEF1A2 ETF1 THERMOGENESIS%WIKIPATHWAYS_20260610%WP4321%HOMO SAPIENS Thermogenesis ARID1A ZNF516 MGLL KDM3B ARID1B SLC25A29 BMP8A SIRT6 SOS1 SMARCD1 SMARCD2 CREB1 SMARCD3 ADRB3 GNAS PRKAA1 AKT1S1 PPARGC1A FGF21 DPF1 DPF3 ACSL1 CNR1 ACSL6 SMARCE1 FACL4 ACSL5 ACSL3 PRKACG MAPK14 MTOR LIPE SOS2 ADCY3 PNPLA2 ADCY1 CPT2 MAP2K3 ADCY8 CREB3 ADCY6 SLC25A20 ADCY5 HEL-S-7a ADCY9 CREB5 BMP8B RPS6KB2 RPS6KB1 UCP1 RPS6KA6 RPS6KA2 RPS6KA1 FRS2 MAP3K5 PRDM16 PRKAB2 SMARCC1 PRKAB1 FGFR1 SMARCC2 CPT1A TSC2 GCG TSC1 NRAS MLST8 ATF2 RPS6 PPARG PRKAG1 CREB3L3 PRKAG2 PRKAG3 CREB3L4 CREB3L2 KDM3A SMARCA4 RHEB PRKAA2 KDM1A ACTG1 GRB2 PS1TP5BP1 CPT1C PLIN1 RPTOR MAPK12 MAPK13 MAPK11 PRKG1 HRAS ACTL6B ACTL6A CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260610%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ELOVL4 CYP46A1 GGPS1 FADS2 FDPS ABCG1 MVK HSD17B7 TM7SF2 PMVK DHCR24 DHCR7 ACAT2 MYLIP CYP27A1 HMGCS1 ELOVL5 NR1H2 FADS1 ACSL1 FACL4 ACSL3 CYP51A1 SCD HMGCR EBP FASN SREBF2 SOAT2 ABCA1 FDFT1 CH25H LBR SQLE SOAT1 SC5D MSMO1 NR1H3 ELOVL2 ELOVL3 MVD THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260610%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ZNF516 MGLL PAX8 KDM3B TRH PIK3CA TTF2 SIRT6 NOTCH1 SLC5A5 TTF1 SOS1 NHSL1 DUOXA2 TG SECISBP2L DUOX2 DEHAL1 SLC26A4 ADRB3 RXRA AKT1S1 MAPK1 PPARGC1A FGF21 BAD SLC16A10 AKT3 DIO1 PFKFB2 MAPK14 MTOR ADCY3 PNPLA2 ADCY8 TPO CREB3 SRC RPS6KB1 UCP1 RPS6KA6 FRS2 POMC SLC16A2 PRDM16 MAP2K1 GSK3B FGFR1 TSC2 ITPR2 TSC1 FOXO1 AQP7 MLST8 ATF2 RPS6 PPARG RAF1 WNT4 THRA MC4R NPY AgRP TBC1D4 SLCO1C1 RHEB SHH KDM1A NR1A2 MDM2 GRB2 PLIN1 RPTOR ITGB3 NPPB CASP9 ITGAV HRAS TSHB MAPKAPK3 ACTL6B TSHR MAFA BREAST CANCER PATHWAY%WIKIPATHWAYS_20260610%WP4262%HOMO SAPIENS Breast cancer pathway HES5 JAG2 NOTCH1 AXIN2 DLL3 DLL4 CSNK1A1 HES1 E2F3 APC PGR PIK3CD FGF8 WNT3A HEY2 RPS6KB1 SKP1 FGF16 CSNK2A1 RB1 CCND1 MYC MAP2K1 MAP2K2 SHC2 SHC3 SHC1 E2F2 FZD7 AXIN1 FZD8 NBN SFRP4 RAF1 DVL2 DDB2 POLK JUN GADD45B GADD45A CDK4 SP1 GADD45G CDK6 FRAT2 GRB2 RAD51 ATM ATR CDKN1A LRP5 PTEN BRCA1 CSNK2A3 CSNK2A2 LRP6 HRAS FZD1 CSNK2B NOTCH3 FOS NOTCH4 PIK3CA SOS1 FGF3 FGF4 FGF6 FGF7 NCOA1 FGF9 CETN3 MAPK1 FGF20 FGF22 MAPK3 FGF21 FGF17 EGFR ARAF DVL3 AKT3 MRE11A FGF19 FGF18 MTOR RAD50 BAX FGF10 KIT FLT4 SOS2 LEF1 TCF7L2 TCF7L1 CSNK1A1L RPS6KB2 FGF2 SHC4 BRCA2 IGF1R APC2 ERBB2 EGF FGFR1 GSK3B WNT2B FZD10 PIK3R3 PIK3R2 IGF1 WNT5B PIK3R1 WNT16 NRAS NR3A2 NFKB2 WNT3 WNT4 WNT10B WNT10A FZD3 FZD5 FGF23 WNT7B FZD9 WNT7A NOTCH2 FRAT1 BAK1 DVL1 WNT1 FZD2 TNFSF11 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias TGFBR2 ADAMTSL2 pp6425 NOG SMAD6 SKI SKIL MAPK3 FBN1 FOXH1 STAT1 TNF STAT3 LTBP1 ENG EP300 LEF1 LEFTY1 SMAD1 CREBBP FKBP1A SMAD4 ZFYVE9 RUNX2 TGIF1 BAMBI INHBA LEFTY2 THBS1 SMAD9 EGF DKFZp781O1323 ZNF423 opn RUNX3 TGFBR1 NFKB1 ITGB6 SMAD2 JUN ZEB2 MAPK9 TGFB1 FST BMP4 HRAS JAK1 IFNG WNT1 LIF FOS TGFBR3 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260610%WP5407%HOMO SAPIENS 15q11q13 copy number variation KAT2B STXBP1 GJC2 SPEF1 SMC5 SMC6 SIN3A ANKRD32 ANKRD2 TJP3 GOLGA8T NSMCE3 NSMCE2 STX1B NSMCE1 GOLGA8K GOLGA8J TJP1 GJD3 MYZAP NECAB3 LYPD6 ENTREP2 UBN1 MLSN2 SLF2 CGN GJA1 CXADR FAN1 RELA CREBBP CANX CCL5 APP GOLGA8R KLF13 OTUD7A GOLGA8O GOLGA8Q MTMR10 TRPM1 GOLGA8H CHRNA7 FANCD2 CDC42BPB CALM1 STX1A HDAC1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260610%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CHRNA3 CACNA1C CACNA1G MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260610%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PLCG1 PIK3CA RAPGEF1 SOS1 CRK PRCC CRKL CDC42 MAP2K1 STRN MAP2K2 PIK3R3 PIK3R2 MAPK8 PAK1 HGF PIK3R1 NRAS MAPK1 MAPK3 RAF1 BAD ARAF INSL3 STAT3 RAP1A AKT3 ALK PTPN11 C8orf34 JUN SOS2 PIK3CD PAK6 PAK4 GRB2 CDKN1A ELOA RPL11 CBL JAK3 SRC HRAS VEGFA KDR RAC1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260610%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 TCIRG1 SNX10 TNFRSF11A NFKB1 RAB7A PLEKHM1 IKBKB TRAF6 TNFSF11 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260610%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NLRP3 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260610%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer HSPD1 PKN1 CUL5 RNF7 THBS1 NQO1 ERBB3 APP GCLC SQSTM1 CTNNA1 HELLS BIRC5 MAPK1 PTK2B AXIN1 NFKB1 VAV3 NRG1 TRAF1 ERN1 TNF HEL-S-7 TNFRSF21 IL7R BEX3 YBX3 IER3 TNFRSF10B NET1 CARD14 CDKN1A CDKN1B HEL-S-102 F2R SOCS3 APOE JUND RIPK2 HEL-S-89n HDAC1 HEL113 RPS6KB1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260610%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex TBP KAT2B H2AC6 ASF1A H2BC12 CHD4 TAF12 TAF1B POLR1A MBD2 POLR1C POLR1D MBD3 MAPK3 RBBP4 H2AZ2 H2AB1 H2AJ CHD3 GATAD2B MTA2 EP300 SRCAP HAT1 ASF1B H3C15 PWWP2B PWWP2A KAT2A H3C8 RRN3 TAF1D GATAD2A H4C9 CDK2AP1 H3F3B HDAC2 CREBBP HIST1H4L UBTF H2AX H2AZ1 TLK2 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 HIST1H2AB SIRT7 H2BC17 H2BC13 H2BC14 H2BC15 H2BC11 HIST1H2BE EP400 H2BC9 H2BC8 H2BC3 H2BC1 H2AC20 HDAC1 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260610%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 FGF19 FXR1 MAPK1 MAPK3 LDLR ABCG8 CYP7A1 ABCG5 ABCB11 FGFR4 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260610%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX15 CYP1A2 EPHX2 ALOX12 HEL-S-22 ALOX15B PTGES GSTM4 CYP3A4 FADS2 CYP2C9 CYP2E1 ELOVL5 FPR2 FADS1 ELOVL2 GPR32 ALOX5 LTC4S PTGS2 PTGIS HPGD PTGS1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260610%WP4249%HOMO SAPIENS Hedgehog signaling DHH SUFU ADRBK1 PTCH2 IHH KIF7 CCND1 SPOP CSNK1A1 SMURF1 KIF3A CCND2 BOC CSNK1G1 DKFZp686L0365 CDON PTCH1 PRKACG EVC GLI3 SHH BCL2 CSNK1G3 GAS1 hCG_2014051 SMURF2 FBXL17 CSNK1A1L SPOPL HHIP CSNK1G2 CSNK1D GPR161 EVC2 SMO CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260610%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias CYP51A1 SC5D EBP DHCR24 DHCR7 LBR PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260610%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH CAMKK2 PATHWAY%WIKIPATHWAYS_20260610%WP4874%HOMO SAPIENS CAMKK2 pathway ATP1B2 HMOX1 GCK KEAP1 MAF MX2 CREB1 SELL DKFZp762B153 VCAM1 PAK1 MAPK1 MAPK3 SLCO3A1 TNF WDR35 PFKFB2 ACACA MTOR KLF1 EP300 FASN RELA TBXT ASNS STIM1 ARHGEF7 MS4A3 CCL5 IFGGE OASL ERMAP SIRT1 HIF1A GALNT9 MAMDC2 EPOR KDR MID1 ERAF RPS6KB1 SPINT1 SFI1 DGIC ATP10D NFATC2 TSPAN33 C1QTNF12 RHD ENHO SLC25A21 WFS1 CXCL11 CPOX CCND1 TMEM176B SQSTM1 TRPV4 AQP1 RHAG HFE NLRP1 CRTC2 SPIRE1 NFE2L2 TSC1 S100A8 CAMKK2 SLC2A4 RPS6 RAF1 FAM20C ULK1 SMC1A PCK2 CAMK1 CCNE1 HMBS HK2 TSPAN8 FIS1 SLC38A5 ABCA1 CYB5R3 CALM1 CHRM3 CAMK4 RPTOR MAP1LC3A RAC1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260610%WP134%HOMO SAPIENS Pentose phosphate metabolism HEL107 HEL-S-304 RPE RPIA MIRNA BIOGENESIS%WIKIPATHWAYS_20260610%WP2338%HOMO SAPIENS miRNA biogenesis DGCR8 DROSHA DICER1 TARBP2 RAN XPO5 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260610%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PHGDH GLS PSAT1 SLC7A11 PSPH DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260610%WP2855%HOMO SAPIENS Dopaminergic neurogenesis NKX6-1 MSX1 DDC CDKN1C SLC6A3 PITX3 SOX2 EN2 LMX1A TH OTX2 ASCL1 LMX1B HEL-S-53e GBX2 STAT3 NEUROD1 RET NEUROG2 NKX2-2 SHH FGF8 TGFB1 SLC18A2 EN1 WNT1 FOXA2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260610%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway DOK1 PIK3CA RPS6KA1 SOS1 CRK CRKL INPP5D SPAG1 HSPB2 BCL9 SHC2 SHC3 BCR SHC1 PIK3R1 NRAS MAPK1 MAPK3 MEF2C ATF2 RAF1 ARAF PXN AKT3 MAPK14 BCLAF1 BCL2 GRB2 GAB2 VAV1 MAP3K2 CBL HEL-S-102 MAPK11 SRC HRAS EIF4B SHC4 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260610%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates MTOR PGAM1 PIK3CA SIRT7 HEL-S-133P HK2 U2AF2 HEL-S-68p FBP1 MYC OTUB2 USP37 USP44 USP28 USP19 VHL G6PC1 FOXO1 OTUD6B OTUD7B HIF1A VEGFA KDR P38 MAPK SIGNALING%WIKIPATHWAYS_20260610%WP400%HOMO SAPIENS p38 MAPK signaling MAP2K4 CDC42 MEF2D MAP3K5 MYC CREB1 RPS6KA5 MAPKAPK2 SHC1 RASGRF1 TGFBR1 TRADD ATF2 HMGN1 STAT1 MAPK14 TRAF2 GRB2 MAP3K7 HEL-S-102 DDIT3 MAPKAPK5 HRAS RIPK1 MAP2K6 MAP3K1 RAC1 SMIM40 MAX EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260610%WP3930%HOMO SAPIENS EDA signaling in hair follicle development LTB BMP1 EDARADD RELB DKK1 WNT3 SHH DKK4 TNLG7C PTCH1 EDAR SOSTDC1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260610%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IFNB1 IKBKG CHUK RELA CCL20 NFKBIA TRAF6 MAPK8 MAP3K7 MAPK1 NFKB1 CXCL8 NFKB2 TRADD MAP3K14 CCL5 PDLIM7 TRAF1 IRAK1 TNF IKBKB SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260610%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX2 STXBP1 AP2A1 AP2A2 SLC38A1 NAPA SYT1 SYP CPLX1 SYN1 SLC22A3 STX1B CPLX2 RIMS1 CLN8 SLC17A8 SLC18A1 DNM3 UNC13C SLC32A1 SYN2 SNAP25 STX3A CLTCL1 UNC13B UNC13A AP2M1 HEL-S-67p SLC18A3 VAMP2 STX1A CLTC SLC17A6 CLTA SLC17A7 AP2S1 CACNA1B CACNA1A SLC18A2 SLC1A3 SLC25A4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260610%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260610%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPI HEL-S-302 ALDH7A1 PIGV ALPL PLPBP HEL-S-1a GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260610%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PRKCB TYRP1 PRKACG TYR PLCB3 PLCB4 POMC DCT MC1R CREB1 PLCB1 PLCB2 GNAS GPR143 ADCY9 ASIP GNA15 DKFZp686L0365 VEGFA PMEL PEPTIDE GPCRS%WIKIPATHWAYS_20260610%WP24%HOMO SAPIENS Peptide GPCRs CCR3 OPRK1 HCRTR2 C3AR1 HCRTR1 CCR8 CCR7 CCR5 CCR4 CCR2 MC3R C5AR1 CXCR4 FPR1 NMBR LHCGR FPRL2 CCKBR TRHR MC2R GALR3 CCR6 GALR2 CXCR5 GALR1 CXCR6 CXCR1 NTSR2 MC1R TACR3 BRS3 CCKAR IL8RB EDNRA EDNRB AVPR1A CXCR3 OPRD1 OXTR FSHR MC5R GRPR NPY1R GNRHR GHSR MC4R ATP8A1 TACR2 CX3CR1 TAC4 NPY5R AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 NTSR1 NPY4R AGTR1 AGTR2 FPR2 AVPR1B CCR10 TACR1 CCR1 SSTR2 BDKRB2 BDKRB1 TSHR NPY2R HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260610%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming PIP4K2A ANKRD13C HDAC2 CADM1 TET2 EP300 NOL9 CREBBP IRS1 HDAC1 IFITM3 EZH2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260610%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260610%WP304%HOMO SAPIENS Kit receptor signaling PLCG1 PRKCB PTPN6 DOK1 PRKCA RPS6KA1 SOS1 CRK CRKL INPP5D MAP2K1 MAP2K2 SHC1 PIK3R2 MAPK8 PIK3R1 LYN MAPK1 GRB7 GRB10 SH2B2 MAPK3 FOXO3A RPS6 RAF1 BAD STAT1 STAT3 PTPN11 MAPK14 EP300 SOCS6 KIT BTK MATK TEC GRB2 GAB2 VAV1 STAT5B CBL SOCS1 SRC FYN HRAS KITLG RPS6KB1 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260610%WP5574%HOMO SAPIENS Oligodendrocyte development NKX6-1 SOX11 BMP1 NFIA HES5 NFATC2 PRKCA MYT1 MYRF SOX2 NKX2-6 SOX6 SOX5 OLIG2 SOX10 TMEM98 ASCL1 CSPG4 SOX8 WNT10A MBP ID4 CHD8 NKX2-2 PTN ZNF24 SHH DUSP15 RELN ZNF488 EGR2 ZBTB33 LGI1 ZEB2 OPALIN GIG8 CNTN1 TCF7L2 SOX9 PDGFRA SMAD1 BMP4 FGF2 OLIG1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260610%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKG CHUK MAPK1 NFKB1 MAP3K14 RAF1 MAP2K6 MAP3K1 IKBKB NFKBIA TRAF6 RRAS PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MAP2K4 HBEGF RB1 IL6 BMF CCND1 FGF7 MAP3K5 MMP2 MAPK8 NFE2L2 ATF2 EGFR CDKN2A TNF CCNE1 MAPK14 JUN BAX CCNA2 BCL2L11 TRAF2 MAP2K3 BCL2 IL2 TRAF6 TRAF5 BAK1 CDKN1A TNFSF10 JUNB PDGFRA MAPK12 MAPK13 MAPK11 TNFSF6 MAP2K6 IFNG BCL2L1 MCL1 FOS TNFRSF1A ARYLAMINE METABOLISM%WIKIPATHWAYS_20260610%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 UGT1A4 SULT1A1 UGT1A9 NAT2 SULT1A2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260610%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling ITGA6 PRKCA SOS1 ARHA SHC1 PIK3R2 ITGB4 PIK3R1 LAMC2 MAPK1 LAMC1 MAPK3 EIF4EBP1 PTPN11 MAPK14 LAMA5 MTOR LAMA1 LAMA3 IRS1 LAMB3 GRB2 LAMB2 LAMB1 SRC HRAS RAC1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260610%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway SPHK1 SGMS2 SGPP1 UGCG SMPD1 SGPP2 DEGS1 PLPP3 PLPP2 KDSR PLPP1 SPTLC2 CERS3 CERS5 SPTLC1 CERS2 CERS6 CERK SGMS1 LASS1 UGT8 DEGS2 SGPL1 SPHK2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260610%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 MTTP GCK LIPC ACSS1 LDLR PLTP SEL1L GPIHBP1 APOA2 LMF1 PDIA2 APOA4 APOA5 LPL APOC2 GCKR DGAT2 FOLATE METABOLISM%WIKIPATHWAYS_20260610%WP176%HOMO SAPIENS Folate metabolism PLAT CBS IL1B CSF1 FOLR1 GPX2 GPX1 MPO TNF GPX3 GPX6 CRP FLAD1 SCARB1 APOB LDLR RELA MAT1A IL2 SLC46A1 MTHFS DHFR MTHFD1 MTHFD2 SLC19A1 CCL2 SHMT1 CTH MTR HEL-S-51e IL6 SERPINA3 HEL-S-44 FGA F7 INSR NFKB1 SAA4 NFKB2 PLG HEL-S-78p ALB SAA1 SAA2 MTRR HBB HBA2 ABCA1 INS IL4 IZUMO1R FOLR3 FOLR2 GPX4 F2 IFNG CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260610%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CA PIK3R4 CCND1 ERBB2 PIK3R3 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 RAF1 EGFR AKT3 CCNE1 MTOR CDK4 IRS1 PIK3CD INS CDK2 CDK6 CDKN1A CDKN1B PIK3R5 RPTOR HRAS PIK3C2G IGF1R PIK3C2B IL7 SIGNALING%WIKIPATHWAYS_20260610%WP205%HOMO SAPIENS IL7 signaling IL7 IL7R MAP2K1 GSK3B MAP2K2 PIK3R2 STAT5B PIK3R1 MAPK1 PTK2B JAK3 MAPK3 FYN BAD STAT1 JAK1 STAT3 IL2RG LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260610%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12B PLA2G5 PLA2G2D PLA2G6 PLA2G4F PLA2G4D PLA2G4E PLA2G4C CDKN1A PLA2G1B ALOX5 SLCO2A1 PLA2G7 PLA2G3 PLA2G10 HRAS PTGS2 PLA2G12A HUNGER AND SATIETY%WIKIPATHWAYS_20260610%WP5445%HOMO SAPIENS Hunger and satiety GHRL AgRP PYY GCG POMC LEP MC4R NPY JOUBERT SYNDROME%WIKIPATHWAYS_20260610%WP4656%HOMO SAPIENS Joubert syndrome ARL3 KAT5 SUFU CEP97 NPHP1 NPHP3 PIBF1 CPLANE1 FLNA TMEM231 TMEM17 AHI-1 ARHA TMEM237 UNC119 INVS TCTN3 TCTN2 TTC8 PDE6A TCTN1 PDE6G CC2D2A OFD1 DVL3 CEP164 MRE11A BBS2 NEK8 MTOR RAD50 BBS1 RP2 TMEM216 PCM1 MYO6 ARL13B TMEM67 MKS1 PDE6D CETN2 BBS9 B9D1 CEP41 BBS7 ZNF423 B9D2 CEP290 BBS5 BBS4 RAB8A ATF4 RHEB SHH ARMC9 ATM INPP5E CCP110 ARR3 ARL2 RPGRIP1L PCNT RAB3IP TMEM138 DVL1 CEP104 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260610%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A TGFBR2 PLCB3 PLCB4 CREB1 PLCB1 PLCB2 CAMK2D TNF IL6ST IL6R IL10 IRS1 IL1R2 PIG59 TRAF5 GRIA2 SOCS3 SLC1A1 SLC1A2 SLC1A3 SMAD4 NGF GLS GRIA3 GRIA4 PSPH PDHA1 GRIN2B GRIN3B GRIN3A IL6 GRIK5 GRIK3 HEL-S-15 GRIK1 PSAT1 GRIK2 GRM2 IL13RA1 CAMKK1 TGFBR1 CAMKK2 GRM8 GLS2 SLC6A9 SMAD2 BCL2 IL4 CNTF CALM1 IL1R1 SLC17A6 SLC17A7 GRIN1 BDNF JAK1 IFNG LIF FOS TGFBR3 IL1B MAPK1 MAPK3 IFNGR1 IFNGR2 STAT1 STAT3 DISC1 ADCY3 ADCY1 ADCY8 PPP1CC HEL-S-80p IL10RB IL10RA FGF2 PRKCB SHMT1 PRKCA HEL-S-51e SLC7A10 ARC SLC38A1 IGF1 GFAP INSR NFKB1 NFKB2 LTA TNFRSF1B SLC2A3 CAMK2G SLC1A4 SLC38A5 PHGDH IL12B DLAT IL12A TGFB1 IL13 DLD CAMK4 NELF SLC38A3 DAO IL1A LRRC8C LRRC8D LRRC8E TNFRSF1A VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260610%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC2LI1 HEL-S-47e DYNC1LI2 DCTN6 DYNC1I1 DCTN5 DCTN1 DYNC1LI1 DCTN4 AQP4 CREB1 HEL-S-77 GNAS DYNC1H1 RAB11B RAB5B CREB3L3 RAB5C CREB3L4 CREB3L2 PRKACG DYNLL2 DNCL1 RAB11A AVPR2 ADCY3 ADCY6 CREB3 VAMP2 DYNC2H1 ARHGDIB RAB5A ADCY9 CREB5 AQP3 AQP2 AVP ARHGDIG STX4A ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260610%WP5124%HOMO SAPIENS Alzheimer 39 s disease TUBA3E MAPK10 TUBA1C TUBB6 TUBA1B TUBA1A PLCB3 PSMD9 PLCB4 TUBB1 PSMD6 TUBB PSMD4 PSMD3 TUBB4B KIF5A PSMD1 PLCB1 TUBB4A PLCB2 TUBA4A TUBB2A SNCA PSMC1 TUBA2 TUBA8 ERN1 TNF PPP3CC TRAF2 VDAC3 ATP2A1 XBP1 DDIT3 CACNA1F APH1B FADD PPP3R2 IRS4 CACNA1S PPP3R1 PSENEN IL6 BACE1 APP MAP3K5 PSEN2 PSEN1 LPL NRBF2 ATG2B MME PSMA2 KNS2 PSMA8 PSMB6 PSMB2 PSMB3 HEL-S-276 RTN3 GPR83 KLC4 KLC3 ADAM17 KLC2 NAE1 BECN2 HEL-S-61 AMBRA1 ADRM1 ATF4 SLC25A31 EIF2AK2 INS EIF2S1 MAPK9 FRAT2 CALM1 CSNK2A3 CSNK2A2 DKK1 DKK2 DKK4 CSNK2B PSMD7 IL1B PSMD12 PSMD13 DVL3 CALML6 CALML3 CALML4 MCU CSNK1A1L PPP3CA CYBB GSK3B WNT2B FZD10 PIK3R3 PIK3R2 WNT5B PIK3R1 ITPR2 NRAS WNT16 RB1CC1 WNT3 WNT4 ULK1 WNT10B WNT10A PPIF FZD3 FZD5 CACNA1C WNT7B FZD9 WNT7A RTN4 FRAT1 SLC25A5 HEL-S-91n DVL1 ATP2A2 FZD2 AXIN2 CSNK1A1 CSF1 PSMC6 APC PSMC4 AGER IRS1 PIK3CD HEL-S-162eP WNT3A SHFM1 HSD17B10 PSMD2 GRIN2B CSNK2A1 PIK3R4 WIPI1 MAP2K1 ULK2 MAP2K2 FZD7 AXIN1 FZD8 SFRP4 RAF1 APAF1 DVL2 CDK5R1 CDK5 CYCS LRP5 GRIN1 CASP9 LRP6 CASP8 CASP3 HRAS FZD1 CASP12 PIK3CA ATG101 WIPI2 ATG14 MAPK8 MAPK1 ATG2A MAPK3 BAD ARAF RYR3 IKBKB AKT3 MTOR CHUK RELA SLC25A6 hCG_2014051 ADAM10 APOE APC2 INSR NFKB1 NOX4 CHRNA7 PSMA4 NOS2 IL1A PTGS2 TUBAL3 WNT1 TUBB8 TNFRSF1A SLC25A4 IL26 SIGNALING%WIKIPATHWAYS_20260610%WP5347%HOMO SAPIENS IL26 signaling CTSK NFATC1 PIK3CA IL6 IL26 DCSTAMP IL1B MAPK8 MAPK1 CSF2 EPHA3 CXCL8 MAPK3 STAT1 MPO TNF STAT3 MAPK14 SMAD2 JUN ACTA2 BAX COX2 IL10 IL33 RELA MAPK9 CCL20 TYK2 NFKBIA IL10RB DDIT3 IL17A IL20RA SOCS3 DEFB4B CASP3 JAK1 ATP6V0D2 MMP9 RORC TNFSF11 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260610%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 MCCC2 ACSF3 IVD DBT MLYCD MCCC1 PCCA PCCB HSD17B10 DLD ACADSB BCAT2 ECHS1 ACAT1 BCAT1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260610%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 FOXG1 TGIF2 GLI3 NODAL SHH NKX2-1 TGIF1 FGF8 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260610%WP3927%HOMO SAPIENS BMP signaling in eyelid development FOXC1 PITX2 FGFR2 JUN NOTCH1 FGF10 FOXC2 SHH DKFZp781O1323 MAPK9 TGFA INHBB SMAD1 MAPK3 SMAD4 DKK2 BMP4 EGFR SFRP1 MAP3K1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260610%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260610%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 SLC2A2 GCG SLC5A1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260610%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 NFE2L2 ATF4 SLC7A5 KEAP1 SLC7A11 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260610%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis MAPK8 RIPK3 FTL TRADD CASP8 TICAM1 RIPK1 FADD TNF TNFRSF1A DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260610%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family GFI1 IL6 IL22 RORA HNF1A IL1B NFIL3 TBX21 IL23A TNF IL5 IL7 AREG TOX GATA3 IL25 AHR IL12B IL12A IL33 GIG8 IL4 IL13 ATL1-beta ZBTB16 IL17A IL9 IL18 TSLP IFNG RORC LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260610%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC2A3 HEL-S-133P HEL-76 NUDT14 SLC1A2 SLC4A4 SLC16A3 CA4 HEL-S-281 SLC16A7 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260610%WP4630%HOMO SAPIENS Measles virus infection MAPK10 LNIR RCHY1 RAB9B CD46 TRADD TBK1 IFNAR2 PIK3CD IRF3 IFIH1 TRAF3 IL2 TYK2 TRAF6 IRF7 TLR7 IFNAR1 IRF9 OAS2 JAK3 TNFAIP3 FADD BCL2L1 OAS3 IFNB1 HSPA2 STAT2 IKBKE MX1 HEL70 CSNK2A1 MAVS IL6 CCND1 RIGI CLEC4M BBC3 HEL-S-72p CCND3 CCND2 APAF1 EIF3S3 CCNE2 CCNE1 JUN HSPA1A IRAK4 CDK4 TLR9 EIF2AK2 CDK2 EIF2S1 BCL2 IFNA5 CDK6 IFNA4 MAPK9 NFKBIA IFNA7 CD209 IFNA6 CYCS IFNA1 IFNA2 IFNA8 OAS1 CDKN1B CSNK2A3 CSNK2A2 CASP9 CASP8 CASP3 IRAK1 JAK1 CSNK2B FOS MYD88 PIK3CA IFNA13 IFNA14 IFNA16 IFNA17 IL1B MAPK8 IFNA10 RAB9A IFNA21 BAD STAT1 STAT3 IKBKB IKBKG CHUK BAX RELA STAT5B EIF2AK1 EIF2AK4 CD3G CD3E PIK3R3 PIK3R2 NFKBIB PIK3R1 TLR4 NFKB1 NFKB2 IL2RG IL2RA IL2RB FCGR2B IL12B IL12A BAK1 TP73 MAP3K7 IL1A TNFSF6 CD3D ADAR SLEEP REGULATION%WIKIPATHWAYS_20260610%WP3591%HOMO SAPIENS Sleep regulation HEL-S-2 UTS2R SLC29A1 PTGDR HCRTR2 HTR2A HCRTR1 IL6 OXTR GHRH UTS2 MRGPRX2 BTBD9 CRH DRD2 CHRNB2 TH NPAS2 DRD1 NPS OXT STAR GHRL ADA DLAT DRD3 IL18 ADORA2A NLGN1 PER3 NPY2R CACNA1I FOS MTNR1B TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260610%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 TNC ID1 CDH2 CDH16 SNAI1 SNAI2 MAPK1 CDH6 MAPK3 SMAD4 RUNX2 HEL113 AKT3 SICKLE CELL DISEASE%WIKIPATHWAYS_20260610%WP5604%HOMO SAPIENS Sickle cell disease TLR4 IL18 HBB HBA2 IL1B INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260610%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition MTOR TBC1D4 INSR SLC2A4 IRS1 RPS6 RPS6KB1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260610%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development PRRT2 ATF4 CSNK2A1 KCNQ2 SPTBN4 SCN2A BRSK1 ANK2 EIF2A SCN5A SPTAN1 DDIT3 CSNK2A2 SNAP25 SEMA3A L1CAM CSNK2B NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NAGA B4GALT1 hCG_1998026 B3GNT5 FUT1 B4GALT4 NEU2 FUCA1 SIAT4C FUT5 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260610%WP4540%HOMO SAPIENS Hippo signaling regulation CDH17 PLCB3 PLCB4 TEAD2 PRKAR1B TEAD3 TEAD4 PRKAR1A CDC42 PLCB1 PLCB2 GNAS ARHA PRKAA1 CDH9 CDH8 CDH6 CDH4 FLT3 EGFR CDH24 PRKACG WWTR1 MTOR PRKD3 KIT FLT4 CSF1R LATS1 CDH2 CDH10 CDH12 LEF1 CDH15 CDH16 CDH19 GNAI3 TCF7L2 TCF7L1 PDGFRA FLT1 NTRK1 IGF1R KDR GNAL FGFR4 PRKCB PRKCI FGFR2 PRKCH PRKCA PRKCQ PRKCZ PRKAB2 PRKAB1 FGFR1 LATS2 INSR NTRK2 PRKAG1 PRKAG2 PRKAG3 FGFR3 SMAD2 PRKCE EPHA2 GNA11 PRKAA2 CDH18 NF2 YAP1 NGFR CDH11 RAC1 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260610%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1 BDH1 OXCT1 ACAT1 ACAT2 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260610%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PIK3CA PIK3CD PLA1A NRAS MAPK1 PTGER1 PTGER2 MAPK3 PTGER3 PTGER4 SRC EGFR HRAS PTGS2 AKT3 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260610%WP2249%HOMO SAPIENS Metastatic brain tumor PIK3R1 E2F3 CDC42 MYC CDK6 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260610%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients NEDD4 TMEPAI SMAD2 TGFBR2 TGFBR1 ATG16L1 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260610%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis NEUROD1 PROX1 WNT7A NEUROG2 LRP6 CCND1 WNT3 FZD1 FZD3 WNT3A CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260610%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response IL6 ITGB1 SELPLG VCAM1 ITGA4 C6 HEL-S-62p C7 SELP CXCL8 KNG1 IL1A TNF ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP1541%HOMO SAPIENS Energy metabolism PPP3R2 MYBBP1A MEF2B PPP3R1 PPP3CA UCP3 MEF2D NCOA1 UCP2 CREB1 PRKAB2 SIRT3 GSK3B PRKAB1 PRKAA1 RXRA FOXO1 PPARGC1A MEF2C ATF2 FOXO3A PPARG PRKAG1 NR1C2 PRKAG2 PRKAG3 PPP3CC MAPK14 CAMK2G EP300 PRKAA2 ESRRA PRMT1 TFB2M NRF1 TFB1M MED1 PPRC1 CAMK4 TFAM PPARGC1B GABPA NR1C1 SIRT1 HDAC1 LUNG FIBROSIS%WIKIPATHWAYS_20260610%WP3624%HOMO SAPIENS Lung fibrosis CSF3 CCR3 HMOX1 ATP11A FGF7 IL1B FAM13A SFTPC RTEL1 DPP9 CSF2 CCR2 STN1 CXCL8 MUC5B SKIL PTX3 SFTPA1 CXCL2 TNF CCL11 ELMOD2 TERT CTGF SERPINA1 CCL5 EDN1 CCL4 FGF2 CCL3 CCL2 MMP9 IL6 EGF MMP2 CMA1 TGFA IGF1 KPG_011 HGF NFE2L2 CEBPB opn SFTPA2 CALCA IL5 PDGFA IL12B IL4 IL13 GREM1 TGFB1 BMP7 TIMP1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260610%WP2253%HOMO SAPIENS Pilocytic astrocytoma PTPN11 NRAS SOS1 RAF1 HRAS NF1 GRB2 INSULIN SIGNALING%WIKIPATHWAYS_20260610%WP481%HOMO SAPIENS Insulin signaling MAPK10 PFKM EGR1 RPS6KA5 PRKAA1 KIF3A STXBP3 STXBP4 RRAD EHD1 EHD2 SNX26 PPP1R3A ARF6 IRS1 PIK3CD RPS6KA4 MAP2K3 XBP1 RAB4A CBL SOCS3 SOCS1 TRIB3 EIF4E MAP2K6 MAP3K1 RPS6KB1 IRS4 MYO1C CBLC RPS6KA6 RPS6KA2 RPS6KA1 PIK3R4 MAP3K8 MAP3K6 MAP3K5 PFKL MAP2K1 MAP2K2 SHC2 SHC3 SHC1 TSC2 TSC1 GRB14 MAP3K10 MAP3K13 MAP3K14 SH2B2 MAP3K11 RAF1 MAP3K12 GSK3A SNAP25 HEL-S-31 EIF4EBP1 FLOT1 FLOT2 HEL-S-61 CAP1 JUN SNAP23 MAP4K2 MINK1 RHEB PRKAA2 MAPK9 GRB2 MAPK7 VAMP2 MAPK6 MAPK4 MAP4K3 MAP3K2 INPP4A GYS2 PTPN1 PTEN HEL-S-42 ARF1 SGK1 MAPK12 SGK2 MAPK13 MAPK11 GYS1 HRAS MAP4K1 RAC1 FOS STXBP1 PIK3CA RAPGEF1 SOS1 CRK MAPK8 MAPK1 PTPRF MAPK3 IKBKB PTPN11 MAPK14 MTOR LIPE SOS2 INPPL1 RPS6KB2 PIK3C2G IGF1R MAP2K4 PRKCB PRKCI PRKCH PDPK1 PRKCA PRKCQ PRKCZ MAP2K5 GSK3B PIK3R3 PIK3R2 PIK3R1 FOXO1 INSR GRB10 SLC2A4 FOXO3A GYG1 ENPP1 TBC1D4 MAP3K7 STX4A DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260610%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport SLC10A2 SLC27A2 CYP7B1 AMACR ABCC3 ATP8B1 AKR1C4 ABCB4 HSD3B7 ABCC2 BAAT CYP7A1 ABCB1 CYP8B1 HSD17B4 ABCB11 SLC27A5 ABCD3 CYP27A1 SLCO1B1 SLC51A AKR1D1 SLC51B FABP6 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 UGCG B3GALT1 NEU4 GLA GBA2 UGT8 B3GNT5 B4GALNT1 A4GALT A3GALT2 B4GALT4 NEU3 ST3GAL5 B4GALT5 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260610%WP4562%HOMO SAPIENS Canonical NF kB pathway REL IKBKG CHUK NFKB1 RELA IKBKB NFKBIA NFKBIE ESTROGEN METABOLISM%WIKIPATHWAYS_20260610%WP697%HOMO SAPIENS Estrogen metabolism CYP1A2 UGT1A3 UGT1A1 NQO1 CYP1A1 UGT2B7 CYP1B1 UGT1A9 CYP3A4 STS SULT1A1 SULT1E1 GSTM1 ARSL UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260610%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 OTC ASL NAGS SLC25A13 ASS1 ARG1 GLS2 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260610%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 DCTN1 DCTN4 PLAGL1 CEP170 OFD1 PLAG1 RAP1A ACTR1B BMERB1 NDE1 ABCC6 MARF1 GATA3 PLK1 DCP1A DISC1 ACTR10 DCP2 RAPGEF4 PCM1 CEP20 PAFAH1B1 ABCC1 KIAA0753 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260610%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PRKCA CDC42 SPRED1 MAP1B MAPKAPK2 GSK3B RHO PAK1 CFL2 PARD6A APC MARK1 NTRK2 NTRK3 STAT3 AURKB PHLDB2 TIAM1 TAOK1 ROCK1 CDC2 MAPRE1 WNT3A TRIO FREP1 PTEN EPHB2 CAMK4 NTRK1 LIMK1 SRC CLASP1 F2RL2 DVL1 RAC1 NOTCH SIGNALING%WIKIPATHWAYS_20260610%WP268%HOMO SAPIENS Notch signaling KAT2B NOTCH4 RBPJ HES5 JAG2 NOTCH1 MAML3 DLL3 DLL4 PSEN2 PSEN1 KCNJ5 HES1 CTBP2 NCOR2 DVL2 DVL3 ADAM17 NOTCH2 DTX4 DTX2 DTX3 LFNG DTX3L MFNG CTBP1 KAT2A MAML1 HDAC2 NUMB CREBBP HDAC1 DTX1 DVL1 APH1B RBPJL NOTCH3 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260610%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 WWTR1 YES1 TEAD2 FGF4 SRRT SOX2 SOX12 POU3F1 UTF1 SOX15 H4C9 ZSCAN10 SOX4 POU3F2 HIST1H4L HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260610%WP186%HOMO SAPIENS Homologous recombination RAD54B RAD50 POLD2 RPA1 NBN RAD52 BRCA2 POLD3 POLD4 RAD51 MRE11A ATM BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260610%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP1 SGPP2 KDSR SPTLC2 SPTLC1 SPHK2 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260610%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs HEL-S-87p MGLL HEL-S-165mP PGAM1 PC KHK LIPE GPD1 HEL-S-68p FBP1 PNPLA2 PFKL HEL-S-162eP ALDOB AGXT PCK1 GLYCTK G6PC1 AQP7 GPD2 ENO1 PKLR AQP9 HEL-S-49 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260610%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KYNU KMO NMNAT1 HAAO TDO2 AFMID NADSYN1 HEL-S-90n AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260610%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction GDI1 ROCK1 ROCK2 MYL1 ADRB2 MYLK PLCB1 IL13 ARHA CALM1 HEL-S-80p PPP1R14A RYR1 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260610%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin GUCY1B1 CAMK2A PRKCA FHL2 PRKAR1A MAP2K1 MAP2K2 ANKRD2 MAPK1 TTN ANKRD1 RAF1 MYPN PRKACG NUP62 TRIM63 ANKRD23 ADRB1 TCAP ADRB2 NBR1 MDM2 CSRP3 HEL-S-101 C22orf13 TRIM55 FHL1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260610%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 SOX4 MED1 PMAIP1 RB1 CCND1 CDK4 CSRP2 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260610%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL12RB1 IL22 IL12B CCL20 TYK2 IL1B IL23R IL17F IL17A CXCL8 HLA-C CXCL1 IL17RC IL23A STAT3 TNF CCR6 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260610%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 MESP2 HES7 DLL3 LFNG EPHA4 RIPPLY2 TBX6 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260610%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation CDH17 ITGA6 ITGAX ITGA1 PLCB4 TEAD2 PRKAR1B TEAD3 TEAD4 PRKAR1A CD44 VGLL4 ITGB1 CTNNA1 ITGA4 ITGA2 PAK1 ITGB7 CDH9 CDH8 CDH6 CDH4 ITGAM FLT3 EGFR CDH24 PRKACG WWTR1 LIN28B ITGA2B KIT FLT4 CSF1R LATS1 CDH2 CDH10 CDH12 CDH15 PPP1CC CDH16 CTGF CDH19 HEL-S-80p PDGFRA AJUBA PPP1R14A FLT1 NTRK1 DCAF1 IGF1R KDR FGFR4 FGFR2 RBX1 CCND1 CUL4A DDB1 MYC FGFR1 ITGB4 LATS2 NRAS INSR ITGB8 ITGB6 ITGAE NTRK2 ITGA7 FGFR3 EPHA2 PAK6 PAK4 CDH18 FOXM1 NF2 YAP1 ITGB3 NGFR ITGAV HRAS CDH11 AMOT FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260610%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor MAPK10 MAPK8 ACTA2 LPA ENPP2 COL1A1 MAPK9 STAT3 RHO TGFB1 CTGF BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260610%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCB ACACB MCCC2 BTD ACACA PC MCCC1 HLCS PCCA GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260610%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ETV4 FGFR2 LHX1 TCF2 CXCL12 HEL-S-28 ITGB1 ROBO2 NCK2 NCK1 EMX2 CXCR4 CD2AP NPHS1 LMX1B NPHS2 WNT4 WT1 CD36 RET FOXC1 NOTCH2 SIX1 HOXD11 SLIT2 GLI3 HOXA11 FOXC2 SHH FGF8 LAMB2 EYA1 FOXD1 TCF21 PAX2 MAFB VEGFA GDNF KDR CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260610%WP2029%HOMO SAPIENS Cell differentiation index HDAC5 TLX2 LEFTY1 TLX1 TLX3 STAT3 LEFTY2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260610%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK1 MAPK3 EGFR JAK1 STAT3 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260610%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 PAX5 ITGAX MFGE8 IRF4 CR1 MAF SELL BCR IRF8 CCR7 IFITM1 CXCR4 CD79A TBX21 CXCL13 CD82 TNF IFIT2 CRP CXCR5 TNFSF13 TNLG7A CCL19 IL10 IFNAR2 IL2 XBP1 TLR7 CCL21 CR2 PDCD1 HEL-S-62p MS4A1 BCL6 ICOS BACH2 AID FCRL5 ISG15 CD1D SLAMF7 PTPRC IL-21 TMSB10 EBI3 IL6 CXCL12 SH2D1A C4A HEL-S-72p CD22 TLR4 FOXO1 CD69 BTLA CD40 CD80 CD40LG CD19 BASH IL12A ZEB2 GPR183 IL4 SYK IFNG GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260610%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways SMUG1 CDK7 POLE TDG POLM POLL NHEJ1 FEN1 POLD3 POLD4 MRE11A FAAP24 FANCM POLD2 CENPX RAD50 FANCL REV1 CUL4B FANCB HMGB1 XPA FANCE FANCF RAD51C BRIP1 FAN1 WRN CENPS MPG OGG1 PNKP XRCC5 UNG RAD54B POLE4 NTHL1 USP1 FANCA MUTYH PALB2 MBD4 MSH3 NEIL3 TERF2 POLE2 BRCA2 POLE3 CCNH CETN2 REV3L XPC POLI GTF2H2C_2 LIG1 APEX2 RFC2 GTF2H2 GTF2H3 GTF2H4 GTF2H5 RFC3 RBX1 RFC4 CUL4A DDB1 ERCC1 CHEK1 ERCC2 ERCC5 MNAT1 H2AX PCNA MSH6 NEIL2 MSH2 NBN RPA1 FANCG WDR48 RFC1 RPA3 DDB2 PRKDC FANCD2 RAP1A POLK APEX1 RAD52 PMS2 RAD51 ATM ATR BRCA1 PARP2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260610%WP100%HOMO SAPIENS Glutathione metabolism GSTT2 HEL-S-26 GCLM GCLC OPLAH GSTM2 GSTA5 HEL-S-64p GPX4 HEL-75 GPX2 GSTM1 GPX1 GPX3 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260610%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC36A2 SLC1A1 SLC3A1 SLC6A19 SLC7A9 SLC7A7 SLC6A20 CLTRN MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260610%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B2 UGT1A1 SULT1A1 SRD5A2 HSD3B2 HSD17B3 HSD3B1 CYP17A1 CYP11A1 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260610%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IFNB1 TBK1 REL IKBKG CHUK IKBKE GSDMD FCGR2A F3 IRF3 RELA NFKBIA IL1B NFKBIE CGAS MITA NFKB1 NLRX1 IKBKB NLRP3 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260610%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC2 RALA NRAS YBX3 CDC42 RAC3 RALBP1 EXOC8 HRAS RAC1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260610%WP5178%HOMO SAPIENS Disorders of fructose metabolism SORD SLC2A2 GLYCTK G6PC1 KHK FBP1 HEL-S-53e SLC5A1 PFKL ALDOB HEL-S-49 COPPER METABOLISM%WIKIPATHWAYS_20260610%WP5189%HOMO SAPIENS Copper metabolism ATP7A SLC31A1 SLC11A2 ATP7B CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260610%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ELOVL4 PLPP6 CYP46A1 GGPS1 IDI2 FADS2 FDPS ABCG1 MVK HSD17B7 TM7SF2 PMVK DHCR24 ACAT2 MYLIP CYP27A1 HMGCS1 ELOVL5 NR1H2 ACSL1 ACSL3 CYP51A1 SCD HMGCR EBP CYP7A1 ABCA1 FDFT1 CH25H LBR SC5D MSMO1 NR1H3 ELOVL2 ELOVL3 MVD GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260610%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism B4GALNT1 SLC33A1 B3GALT1 FUT1 A3GALT2 ST6GALNAC6 ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 ST3GAL1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CD226 BMI1 KLRK1 NCR3LG1 TIGIT NCR1 MICB CD96 NCR3 MYC PRF1 MICA FCGR3A FOXO1 CSF2 TNF GATA2 ADAM17 CCL1 ADAM10 CCL5 CCL4 CCL3 CCL2 IFNG HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260610%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells TYROBP PLCG1 PTPN6 LCP2 PRKCA PRKCQ NLRP7 NLRP2 ELF3 LAT VAV1 SYK CSF2 HLA-C FYN IFNG TNF KIR2DL1 RAC1 KIR2DL3 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260610%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IFNA16 IFNA17 IL1B POLR1C IFNA10 POLR1D TRADD IFNA21 IKBKB TBK1 IKBKG TRIM25 CHUK POLR2H POLR2K POLR2L POLR2F IRF3 IL33 RELA IRF7 POLR3GL POLR3A CCL5 POLR3B CCL4 POLR3C POLR3D RIPK1 ISG15 CCL4L2 FADD POLR3E POLR3F POLR3G IFNB1 POLR3H POLR3K IKBKE MAVS IL6 ATG12 DKFZp686F0183 ZBP1 RIGI RNF125 PYCARD NFKBIB RIPK3 AIM2 NFKB1 CYLD NLRX1 IFNA5 IFNA4 IFNA7 TREX1 NFKBIA IFNA6 IFNA1 CGAS CASP10 IFNA2 MITA IFNA8 IL18 CASP8 ADAR INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260610%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 CCND1 TOR1AIP1 CSNK1A1 GSK3B HES1 CEBPB CEBPD opn AXIN1 SLC2A4 PPARG WNT10B APC DICER1 CEBPA HMGA2 LEF1 ZMPSTE24 CDK6 EMD LMNA TCF7L2 TCF7L1 CSNK1A1L TARBP2 AGO2 RUNX2 FNTA ICMT JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members SKP1 HDAC3 HDAC2 BTRC RBX1 DTX3L STAT1 PARP11 STAT3 PARP14 ONE CARBON METABOLISM%WIKIPATHWAYS_20260610%WP241%HOMO SAPIENS One carbon metabolism SHMT1 MTR HEL-S-51e MTRR TCN2 HEL-S-61p MTFMT MAT1A CHDH AMT GLRX MTHFS FTCD DHFR FOLH1 MTHFD1 AHCYL2 MTHFD2 TYMS DNMT3B HEL-S-70p MTHFD1L NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260610%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway MAPK10 MAPK8 CXCL8 TRADD TNF IKBKB TBK1 MAPK14 DHX58 IKBKG TRIM25 CHUK TRAF2 IRF3 DDX3X IFIH1 TRAF3 RELA TRAF6 IRF7 TANK RIPK1 ISG15 FADD MAP3K1 IFNB1 IKBKE MAVS SNW1 ATG12 CXCL12 DKFZp686F0183 RIGI RNF125 DDX3Y AZI2 NFKBIB OTUD5 SIKE1 PIN1 NFKB1 CYLD TBKBP1 IFNK NLRX1 MAPK9 NFKBIA IFNA1 CASP10 MITA MAP3K7 MAPK12 MAPK13 CASP8 MAPK11 IFNE IFNG GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260610%WP5166%HOMO SAPIENS Glyoxylate metabolism AGXT SLC26A1 GOT2 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 DAO PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260610%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation AKR1B1 TBXA2R PTGDR PTGIR AKR1C1 ANXA2 AKR1C2 ANXA6 S100A6 PTGER1 PPARGC1A PTGER2 PTGER3 PTGFRN PPARG ANXA3 ANXA4 S100A10 ANXA1 SCGB1A1 PTGIS CYP11A1 HEL-S-7 PTGES SOX9 HSD11B1 HSD11B2 PRL EDNRA PPARGC1B PTGER4 EDNRB EDN1 PTGFR PTGS2 HPGD PTGS1 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260610%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling HEL-S-22 MAPK14 SRXN1 ABCC6 JUN EPHX1 HMOX1 NQO1 GCLM KEAP1 ABCC3 GCLC ABCC2 MAPK8 NFE2L2 MAPK12 MAPK13 MAPK11 NQO2 FOS ABCG2 CES1 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260610%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PDGFD PDGFC CD226 TNFRSF4 ENTPD1 NR1i1 PDCD1LG2 TNLG5A IL6 TIGIT TNLG2B CXCL12 TNFRSF9 VEGFB VEGFC CXCR4 CD40 CD80 HLA-A CTLA4 VTCN1 VSIR B2M CD40LG FAP PDGFA HAVCR2 IL10 SHH LGALS9 ARG1 IL4 TGFB1 IL13 CCL22 NT5E CCL17 VEGFD PDCD1 ICOS TNFSF6 VEGFA IDO1 ALSTROM SYNDROME%WIKIPATHWAYS_20260610%WP5202%HOMO SAPIENS Alstrom syndrome IFT74 ALMS1 IFT81 TFDP2 DNM3 CEP192 PTCH1 BLOC1S4 VCPIP1 ACTN4 BLOC1S6 BLOC1S1 CIMAP3 SNAPIN RFX2 DTNBP1 CEP19 RFX3 RFX1 TUBG1 RILPL1 MYO5B VCP STX5A RABL2B E2F4 GPR161 IFT27 IFT172 IFT25 SMO ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260610%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis GNA13 TBXA2R ARHGEF1 PTGS1 ARHA FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260610%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260610%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt IGF1 GNRH1 SST GHRH GH1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260610%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS1 PEMT CEPT1 CHKB PTDSS2 PCYT1B PCYT2 PISD SGPL1 CHKA CHPT1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260610%WP3941%HOMO SAPIENS Oxidative damage response MAP2K4 MAPK10 C3AR1 CDC42 TNK2 CDKN1C PCNA NFKBIE C1QA C5AR1 NFKB1 APAF1 BAD TRAF1 TNF TNFRSF1B C4B_2 C1QB GADD45A TRAF2 BCL2 TRAF3 TRAF6 C1S BAG4 BAK1 CYCS CDKN1A CDKN1B CR2 CASP9 MAPK13 CASP3 C1QC MAP3K1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260610%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY GCG FFAR3 FFAR2 SLC2A4 NR1C2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260610%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP2K4 MAPK10 MAP3K8 MAP3K5 MAP2K1 MAP2K2 MAPK8 TNKS MAPK1 MAP3K10 MAPK3 MAP3K11 RAF1 MAP3K12 ARAF MAPK14 ATF4 MAP2K3 MAPK9 MAP3K21 MAP3K7 MAPK12 MAPK13 MAPK11 MAP2K6 MAP3K1 PARP14 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260610%WP183%HOMO SAPIENS Proteasome degradation UBB PSMD7 UBC UBE2B PSMD9 PSMD6 PSMB8 PSMD4 PSMD5 PSMD3 RPN2 PSMD1 RPN1 PSMD10 H2AX PSMB9 HEL-117 PSMD11 PSMC1 NEDD4 PSMD12 PSMD13 H2AZ1 PSMA2 PSMC6 PSMB6 HLA-B PSMB2 HLA-C UBE2D1 PSMB3 HEL-S-276 HLA-A HLA-F UBE2D3 HLA-G PSMC4 HLA-E HIST1H2AB PSMA4 UBA7 PSMB10 HEL-S-283 PSME2 HEL-S-91n IFNG UBE2D2 PSMD2 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260610%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A2 MTOR INS-IGF2 PRKCZ IRS1 PDX1 MAPK8 SURF1 PIK3R5 MAPK1 INSR SOCS4 SLC2A4 CACNA1A PHKA2 TNF MAFA IKBKB METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260610%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLCG1 BMP1 P4HA1 HEL-S-133P GCK LPAR1 ALDH18A1 GLUD1 PHGDH PSAT1 FGFR1 LOXL2 ARHA P4HA2 P3H4 PLOD1 P3H3 ADAMTS2 P4HA3 GLS UGDH CD36 PSPH FGFR4 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260610%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 LPL LIPC APOB USF1 GHR LDLR PLTP GPIHBP1 APOA2 PCSK9 APOA4 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260610%WP2197%HOMO SAPIENS Endothelin pathways PTGIR GNB5 PRKCA ADRA1A CAD MYL1 PLCB1 MAP2K1 GNAS NPY1R HEL-S-14 MAPK1 RAF1 NPY CALCA GNAI1 CALCRL COX2 ADRB1 MYLK CALM1 HEL-S-7a ECE1 GNA15 RAMP1 EDNRA EDNRB EDN1 RIIAD1 ATP2A2 GNG13 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260610%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS NOTCH1 CR1 CDKN1C HEL-S-28 ITGB1 YWHAQ COL4A3 COL4A5 WT1 SMARCAL1 CD151 MYO1E HEL114 CDH2 IRF6 COL4A4 PLAUR FYN FAT1 TLN1 VTN PLCG1 AGRN PARVA PCNA PTPRO ITGB4 SYNPO NCK1 TLR4 MME CD2AP INF2 LMX1B NPHS1 NPHS2 CD80 DAG1 PLCE1 LAMA5 ACTN4 MYH9 CLDN1 TGFB1 LAMB2 CDKN1A LRP5 CDKN1B PAX2 ITGB3 CTSL LRP6 SCARB2 DKK1 ITGAV MKI67 KIRREL3 TRPC6 KIRREL2 WNT1 LIMS1 HEL113