S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 UBE2I XPO1 SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PTPN11 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE DAB2IP PRKCA RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 CALM3;CALM1 EIF3A PTPN11 IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB FRS2 ARHGAP35 PTPN11 IGF1R KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 CENPA SMC4 NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN POMC MC4R APH1A NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 WNT7A FZD8 KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 CALM3;CALM1 KIF5B PTPN11 CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 ELF2 PTPN11 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 ITGA6 LAMC2 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 PPP2R5A WWP1 NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 FRS2 PTPN11 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 MAPK8 APH1A CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FRS2 FOS PTPN11 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 RHO SAG CNGA1 PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B SNAP25 RIMS1 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 NFATC4 MAPK10 PTPN11 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB CXCR2 PRKCA RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 C4BPB SOD1 CYP2C18-1 SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 PRKCA ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 EIF2A WWP1 PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 NFATC1 XPO1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB CALM3;CALM1 PTPN11 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 MST1R PRKCA GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 CENPA AURKAIP1 MDM2-2 GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 KREMEN2 APH1A CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL SHH NQO1 WWP1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A CALM3;CALM1 PTPN11 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 POMC MAPK8 SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD MALT1 ERC1 TNFAIP3 PRKCA RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis BCAT2 ILVBL BCAT1 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 PGD TKT HK2 HK1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism GALT ALDOC ALDOB HKDC1 ALDOA KHK HK2 HK1 GALE P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PIK3C3 PRKCQ PRKD2 PRKD1 CRYAA;CRYAA2 RAF1 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 IL12RB1 ELK1 MAPK6 IL12RB2 STAT5A STAT5B MKNK1 IL10RB MKNK2 STAT1 IL10RA STAT2 STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 MAPK3 NOS3 BRAF IL21 GSK3B CDKN1A SPI1 CDKN1B CXCL8 IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 SPIC RPS6KA3 RPS6KA6 RPS6KA2 MYC AKT2 AKT3 RPS6KA1 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK IL11RA IL15 PDPK1 IL13 IL18 FOS IL1A IL23A IL3RA IL6ST SOS1 SOS2 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis FECH EPRS1 UROD HMBS RSAD1 CPOX PPOX EARS2 COX10 ALAD QARS1 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway PPP1R1B KCNK3 CHRNA3 CHRNA5 KCNK9 CHRNA4 EPB41 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 SLC18A2 DRD4 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 CRY2 CRY1 TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis PMVK PDSS1 MVD HMGCR LSS FDFT1 HMGCS1-1 SQLE FDPS MVK GGPS1 IDI2 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 PIK3R3 PIK3R2 PIK3R1 NRAS MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 CCNE1 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 TPTE;TPTE2 PIK3CD RBL1 PIK3CB CDK2 PIK3C2A CCNG1 CTNNB1 PIK3CG AKT2 KRAS PIK3C2B AKT3 ATM TP53 TP73 ATR AKT1 HRAS PDPK1 PIK3CA PIK3C3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCZ PLCG2 PLCG1 ITPR1 ITPR2 ITPR3 PRKCG GNA14 PRKCI GNG10 GNG2 PRKCH HRH1 PRKCB GNG5 PLCZ1 PRKCE GNG4 GNA11 PRKCD GNG8 PLCE1 PRKCA PLCL1 PLCB3 PLCB4 GNB2 GNB1 PRKCQ METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GNAQ HOMER1 GRIK5 PRKX GRIK1 GRIN2C GRIN2B GRM1 GRIN2D ITPR1 GRIN1 PRKACB-1 GRM5 PRKACA-1 GRIN2A GRIN3A PRKCB PRKAR1B PRKAR1A GRINA GNA11 PLCB4 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 KCNK3 GNB3 GNB5 PRKX PRKACB-1 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A HTR1E HTR1F HTR1D HTR1A HTR1B GNAO1 KCNK9 ADCY2 GNAI1 PRKACA-1 GNG10 GNG2 GNG5 GNG4 GNG8 GNB2 GNB1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCZ PLCG2 PLCG1 OXTR PRKCG GNA14 PRKCI GNG10 GNG2 PRKCH PRKCB GNG5 PLCZ1 PRKCE GNG4 GNA11 PRKCD GNG8 PLCE1 PRKCA PLCL1 PLCB3 PLCB4 GNB2 GNB1 PRKCQ 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNB5 HTR4 GNAL ADCY2 GNG10 GNG2 GNG5 GNG4 ADCY7 GNG8 GNB2 GNB1 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GNB4 GNB3 PRKACB-1 PRKAR1B PRKAR1A GNAI3 ADCY7 PRKAR2B PRKAR2A GNAO1 CACNA1B ADCY4 CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 GABBR2 ADCY2 GABBR1 ADCY9 GNAI1 CACNA1G PRKACA-1 GNG5 GNG4 GNG8 GNB2 GNB1 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K UBE2B UBE2D4 UBA7 UBA6 UBE2C UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 GSK3B TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 PSEN2 LRP5 WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH1B1 ALDH3B2;ALDH3B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 TP63 TP53 TP73 COP1 MDM2-2 MDM4 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis BCAT2 ILVBL BCAT1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG RAC1 HRAS PRKCB PRKCD PPP3CA PPP3CB BLNK PIK3CA VAV3 SYK NFKBIL1 VAV1 VAV2 BTK RAF1 CD79B MAPK9 CD79A MAPK8 CD19 LYN MAP3K2 MAP3K3 JUN NRAS CALM3;CALM1 MAP2K2;MAP2K1 MAPK10 PLCG2 NFKBIA PTPRC MAPK1 PTPN6 GRB2 MAPK3 CD22 IKBKB ITPR1 ITPR2 ITPR3 CHUK FOS SOS1 SOS2 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation TP63 AKT2 AKT3 TP53 TP73 AKT1 IGBP1 PRKAA1 PRKAB2 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 PPP2CB;PPP2CA EIF4EBP1 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis LIPH LPL PLA1A PLCB1 PLCB2 PLCB3 DAGLA MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB PMM1 GMDS PMM2 MPI GMPPA MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 EGLN2 RORC MTOR ARNT TXN TXN2 VHL THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 PRKAR1B GTF2F1 PRKAR1A GTF2H3 GTF2F2 GTF2H4 TBPL2 PRKAR2B TAF8 PRKAR2A TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 CREBBP GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNB4 OPRD1 GNAO1 GNB3 POMC GNB5 ADCY2 GNAI1 GNG10 GNG2 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB2 GNB1 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled GNAQ PLCB1 PLCB2 PRKACB-1 PRKAR1B PRKAR1A ADCY7 PRKAR2B PRKAR2A ARAF GNAL ADCY4 ADCY1 ADCY8 ADCY6 ADCY5 GUCY1B1 EDNRA EDNRB AKT1 ADCY2 PRKG2 ADCY9 PRKG1 PRKCG GUCY1A2 PRKACA-1 GUCY1A1 PRKCI EDN1 PRKCH EDN2 PRKCB EDN3 PRKCE GNAS-1 ADCY3 PRKCD ADCY10 PLA2G4A PRKCA PRKCQ RAF1 PRKCZ MAP2K2;MAP2K1 MAPK1 MAPK3 NOS3 AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCZ PLCG2 PLCG1 PRKCG GNA14 PRKCI GNG10 GNG2 PRKCH PRKCB GNG5 PLCZ1 PRKCE GNG4 GNA11 PRKCD GNG8 PLCE1 PRKCA PLCL1 HTR2B PLCB3 HTR2A PLCB4 GNB2 GNB1 PRKCQ INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS PIK3CA PIK3C3 COL16A1 COL12A1 ITGA2B ARPC5L CRKL RAF1 MAP3K5 MAP2K3 COL27A1 PXN ACTN2 PIK3R3 ACTN1 PIK3R2 ACTN4 PIK3R1 COL4A2 COL4A1 COL4A4 NRAS COL4A3 MAP2K2;MAP2K1 ACTG1 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 MAPK3 ELMO2 TLN1 BRAF VCL PTK2 COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 PARVA PARVB ARPC5 ARHGAP26 COL1A2 COL5A1 ACTBL2 LIMS4;LIMS1 ARPC2 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 LAMC3 ITGB4 COL14A1 ARPC1B ITGB2 ARPC1A ILK LAMC2 LAMC1 SOS1 ITGAE SOS2 RND2 ITGAL RND3 RND1 ITGAX ITGB8 COL10A1 ITGAV ITGB7 MAPK6 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 ACTB-1 RAPGEF1 ITGA8 ITGA7 SHC1-1 COL6A3 ITGA6 ITGA5 DOCK1 CRK ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 LAMA4 COL11A1 LAMA3 COL11A2 NTN4 ASAP1 CDC42 MICALL1 PTK2B FYN CSK FLNB LAMB3 LAMB2 LAMB4 FLNA LAMB1 PTPN12 COL3A1 LIMS2 BCAR1 MAPK9 MAPK8 MAP3K2 MAP3K3 MAPK10 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway SRF ELK1 RPS6KA4 RPS6KA5 MKNK1 MKNK2 MAP3K4 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 ARHGAP26 RPS6KA3 RPS6KA6 RPS6KA2 MYC AKT2 RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 ARHGAP10 SHC1-1 EHF ARHGAP42 VAV3 OPHN1 GRAP2 PDGFRB VAV1 PDGFRA VAV2 PDGFRL ERF ERG SHC3 PDGFB MAPK8 PDGFA ARHGAP15 ARHGAP12 MAP3K2 SRGAP3 SRGAP1 JUN FLI1 FEV MAPK10 GRAP ARHGAP9 GSK3A GRB2 ARHGAP5 ARHGAP6 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA NCK1 JAK1 GAB1 RPS6KB1 GAB2 ETV3 RPS6KB2 ELF1 ELF2 ELF3 PIK3R5 ELF4 RASA1 ELF5 RASA2 RPS6KC1 SPDEF MYCBP-1 ELP1 USF2 RAB11B NIN PKN2 ITPR1 ITPR2 ITPR3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 CHRNA10 MYH14 MYH11 MYH10 MYH7B MYO10 MYO5A MYO19 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A ACTB-1 MYO5B MYO5C MYO1F CHRNA3 CHRNA5 CHRNA4 CHRNA6 CHRNB2 CHRNB4 CHRNB3 ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A MYH1 SLC5A7 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT3 STAT4 STAT6 JAK2 STAT5A JAK1 STAT5B STAT1 JAK3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PIK3R3 PIK3R2 PIK3R1 PLCG2 PLCG1 VASP NTN1 PIK3R5 NTN3 ABLIM1 NTNG1 NTNG2 PIK3CD DCC PIK3CB UNC5B PIK3C2A NFATC3 NFATC2 PIK3CG UNC5C PIK3C2B UNC5D NFATC4 NTN4 RHOU CDC42 RAC1 PIK3CA ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A16 SLC6A15 SLC6A20 SLC18A1 SLC6A2 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYH13 MYH14 MYH11 MYH10 MYH7B RHOC ACTB-1 RHOU CDC42 RAC1 MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 PFN3 ACTC1;ACTG2 TUBB3;TUBB6 ROCK1 ROCK2 PAK1 ACTG1 PAK3 PAK2 PAK5 PAK4 LIMK1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ACTA2 ARPC5 ACTA1 ACTBL2 ARPC2 ARPC3 MYH1 MYH3 ARPC1B MYO3B MYO3A ARPC1A MYH8 MYH9 MYH6 MYH7 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade RAF1 MAP2K3 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 MAPK3 IRS4 IGF1R INS;INS-IGF2 INSR RPS6KB1 INSRR IRS1 IGF2 RPS6KB2 IGF1 IRS2 IGF2R RASA1 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 FOS SOS1 SOS2 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 IFNGR2 JAK2 JAK1 STAT1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 UCKL1 ADAT2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway SLC1A1 SLC1A2 GNB4 SLC1A3 GNB3 SLC1A6 GNB5 CACNA1E SLC1A7 VTI1A SLC17A7 GRIA3 GRIK5 GRIA4 PRKX GRIK1 GRIN2C GRIN2B GRM1 GRIN2D GRIN1 PRKACB-1 GRM5 GRIN2A GRIN3A PRKAR1B PRKAR1A GNAI3 GNAI2 PRKAR2B PRKAR2A CACNA1B CACNA1A GNAI1 PRKACA-1 ADCY10 GNB1 SNAP25 SNAP23 GRIK3 GRIK4 GRIK2 GRM4 GRM7 GNG10 GRM6 GRM8 GNG5 SNAP29 CACNB1 GNG4 VAMP8 VAMP1 GNG8 VAMP2 STX1A VAMP3 GRIA1 GRIA2 GNB2 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway ATF1 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 MAP2K4 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 TNFRSF1B TNFRSF1A GZMH-1 MADD LTA TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A LTB ATF6 JDP2 BIRC2 ATF3 PIK3CD BIRC3 PIK3CB ATF4 ATF6B CREM PIK3CG XIAP RELA CASP9 RELB CYCS-1 BCL2L11 RIPK1 AKT1 BAK1 FADD MAP2K7 PRKCG MAP4K3 MAP4K4 PRKCH MAP3K1 PRKCB CRADD BIK PRKCE EIF2AK2 DIABLO-1 PRKCD EIF2S1 NFKB1 PRKCA NFKB2 PIK3CA ATF7;ATF7-NPFF PRKRA REL PRKCQ BCL2 BAX FAS MAP3K14 BCL2L1 MAP3K5 MAPK9 MAP2K3 MAPK8 JUN MAPK10 NFKBIA MAPK1 MAPK3 IGF2R IKBKB AKT2 AKT3 TP53 CHUK FOS LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT2 BCAT1 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway SRF ELK1 ATF2 STAT1 RHOC RHOA STAT3 MAP3K4 RHOB MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF PIK3CD PIK3CB ETS1 PIK3CG RAC3 CDC42 AKT1 RAC1 HRAS MAP2K7 MAP3K1 PIK3CA PIK3C3 RAF1 MAP3K7CL MAPK9 MAP2K3 RALA-1 TIAM1 MAPK8 EXOC2 RALB PLD1 PLD2 RALGDS JUN NRAS RGL1 PAK1 MAP2K2;MAP2K1 MAPK10 PAK3 PAK2 GSK3A MAPK1 GRB2 MAPK3 BRAF GSK3B RPS6KA3 RPS6KA6 RPS6KA2 KRAS AKT3 RPS6KA1 PDPK1 SOS1 SOS2 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin GNAQ GNB4 GNB3 GNB5 RAF1 PLCB1 PLCB2 ELK1 ARRB1 MAP2K2;MAP2K1 ARRB2 GRK3 GRK2 MAPK1 EGR1 MAPK3 AGT AGTR1 ITPR1 ITPR2 ITPR3 GNG10 GNG4 GNG8 PRKCA PLCB3 GNB2 GNB1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway EP300 HDAC1 WRN CCNB1 SUMO1 SIN3A CDKN1A SUMO3 TRAF2 CHEK2 CCNE1 SUMO2 HMGB1-1 SFN MTA2 PTEN GTSE1 CDKN2D GADD45B TP63 CDKN2A GADD45A TPTE;TPTE2 CDC25C SIRT1 PML CDK2 GADD45G KAT2B AKT2 KAT6B AKT3 CDK1 ATM TP53 TP73 ATR MDM2-2 AKT1 CREBBP MDM4 PDPK1 PIK3CA THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway GNAQ GNB4 GNB3 GNB5 PLCB1 CACNA1E PLCB2 PLCD4 PLCD1 CACNA1B CACNA1A PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA PRKCQ GNB1 PRKCZ PLCG2 PLCG1 TRH TSHB TRHR SNAP25 CACNB2 SNAP23 CACNB3 CACNB4 STX3 CGA GNA14 GNG10 GNG5 PLCZ1 SNAP29 CACNB1 GNG4 VAMP8 GNA11 VAMP1 GNG8 PLCE1 VAMP2 PLCL1 PLCB3 VAMP3 PLCB4 GNB2 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CDH9 CELSR2 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 ACTC1;ACTG2 PCDHB15 WNT2B PCDHB14 FZD10 PCDHB5-1 PCDHB16 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 CTNNB1 CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYSL3 UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYSL2 DPYS DPYD ABAT ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNB4 GNB3 ADRB1 GNB5 GNAL PRKX ADCY2 PRKACB-1 PRKACA-1 GNG10 GNG2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB2 GNB1 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade FOXO3 TPTE;TPTE2 FOXO1-1 MDM2-2 MDM4 GSK3A PDPK1 GSK3B IRS4 TSC2 TSC1 IGF1R INS;INS-IGF2 INSR INSRR PIK3CA IRS1 IGF2 IGF1 PTEN IRS2 IGF2R HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNB4 GNB3 GNB5 GNAL HRH2 PRKX ADCY2 PRKACB-1 PRKACA-1 GNG10 GNG2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB2 GNB1 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNB5 GNAL ADRB3 ADCY2 GNG10 GNG2 GNG5 GNG4 ADCY7 GNG8 GNB2 GNB1 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism GDA AMPD3 XDH NT5E METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNAQ GNB4 GNB3 POMC GNB5 GNAL CRHR1 CRHR2 CRH GNA14 GNG10 GNG2 GNG5 GNG4 GNA11 GNG8 GNB2 GNB1 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway CHRNA7;CHRFAM7A MAPK7 MAPK6 MAPK15 MAPK14 MAPK12 MAPK13 MAPK11 CACNA1C PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PRKCQ MAPK9 MAPK8 APP PRKCZ MAPK10 KAT5 MAPK1 MAPK3 PSENEN BACE1 BACE2 PKN2 ADAM17 CACNB2 PKN3 PSEN2 CACNA1D CACNA1F KLC1 KLC4 KLC3 PSEN1 KLC2 CACNA1S MAPK4 APBA1 CACNB1 PKN1 NCSTN APBA3 APBA2 APH1B CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway MRAS PHLDB2 RASAL2 EGFR ERBB3 ERBB2 STAT4 STAT6 SPRY4 DAB2IP SPRY3 NF1 STAT5A SPRY2 STAT5B SPRY1 STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B AKT1 RAC1 HRAS MAP2K7 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PIK3CA PRKD3 PIK3C3 PRKCQ PRKD2 PRKD1 RAF1 MAP3K5 MAPK9 MAP2K3 SHC2 SHC3 MAPK8 MAP3K2 MAP3K3 PRKCZ NRAS MAP2K2;MAP2K1 MAPK10 PLCG2 GRAP MAPK1 PLCG1 MAPK3 BRAF RASA4;RASA4B GAB1 GAB2 RRAS PIK3R5 RASA1 RASA2 AKT2 AKT3 PEBP1 ERBB4 PEBP4 RRAS2 SOS1 GAB3 SOS2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 MMP3 SERPINF2 FGG SERPINE1 PLAUR PLAT PLG MMP9 MMP13 PLAU PNAT%PANTHER PATHWAY%P05912 PNAT PPP1R1B GNB4 KCNK3 GNB3 PRKX PRKACB-1 GNAI3 ADCY7 GNAZ GNAI2 PPP1CC PRKAR2B PRKAR2A DRD1 DRD5 KCNK9 EPB41 SNAP25 SNAP23 ADCY2 GNAI1 STX3 PRKACA-1 SLC6A3 EPB41L1 EPB41L2 FLNA SNAP29 GNG4 DRD2 SLC18A2 VAMP8 GNG8 DRD4 VAMP1 VAMP2 VAMP3 PPP1CA GNB2 GNB1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway STK36 FBXW11 PTCH1 BTRC GLI1 GLI3 SHH CREBBP SMO MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B SLC6A8 PRKAR1A GNAI3 GNAI2 PRKAR2B PRKAR2A GNAO1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ9 KCNJ3 GNAI1 SLC18A3 PRKACA-1 GNG10 GNG5 SLC5A7 GNG4 ADCY10 GNG8 GNB2 GNB1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism NPL GFPT2 GFPT1 GNPDA1 GNPDA2 AMDHD2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway ATF2 EP300 MAP3K7 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 ACVRL1 HRAS BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 MAP3K7CL MAPK9 GDF10 SMAD1 MAPK8 GDF11 SMAD4 TGFB2 JUND SMURF2 JUN GDF15 NRAS TGFB3 SMURF1 MAPK10 SKIL GDF2 BMP8B MAPK1 GDF1 SMAD9 MAPK3 INHBB GDF3 INHBA GDF6 SMAD6 BMP7 GDF5 INHBC SMAD5 ACVR2B RRAS BMP6 ACVR2A INHBE BMP5 SMAD7 GDF7 SKI BMP4 FOSL1 BMP3 GDF9 BMP2 BMP1 GDNF TLL2 TLL1 BMPR1B NODAL BMPR1A CREBBP DCP1B BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F8 ITGA2B F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 F3 GP5 PROCR F7 GP9 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway GNAQ FOXO3 GNB4 GNB3 GNB5 PTGER1 PIK3R3 FOXO4 PIK3R2 GNGT1 PIK3R1 YWHAZ NRAS NOS3 GSK3B GNAI3 GNAI2 INSR RPS6KB1 IRS1 RPS6KB2 PIK3R5 FOXO1-1 PIK3CB GNAT2 AKT2 AKT3 CASP9 AKT1 GNAI1 GNA14 PDPK1 GNA11 PIK3CA SOS1 GNB2 GNB1 SOS2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CREB3L3 CREB3L4 CREB3L1 CREB3L2 GNGT1 CHRM3 EP300 CHRM1 CHRM5 HTR6 HTR7 GRM1 ADORA3 ADORA1 PHKA1 PRKACB-1 PHKA2 GRM5 MTNR1A MTNR1B PRKAR1B ADRB2 PRKAR1A HRH3 CLTCL1 HRH4 GNAI3 PHKB ADCY7 PYGB GNAI2 PRKAR2B CLTC PRKAR2A CLTB HTR1E CLTA HTR1F PYGM HTR1D ADRA1D HTR1A PYGL HTR1B ADRA1B CREB5 ADRA1A OPRD1 GYS2 HTR4 GRM3 GNAL GYS1 GRM2 GNRHR ADCY4 OPRM1 SSTR1 ADCY1 ADRA2C ADCY8 SSTR2 ADCY6 ADRA2B ADCY5 SSTR3 KCNJ3 SSTR4 SSTR5 ADCY9 CREB3 CREB1 ADORA2A ADORA2B OPRL1 PHKG1 PHKG2 OPRK1 ADCY3 GPR50 HTR5A HTR2B HTR2A GSK3B RAP1B RAP1A ADRB1 HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 DRD1 DRD5 CHRM2 CHRM4 CREM KCNJ5 KCNJ6 KCNJ9 ADCY2 GNAI1 PRKACA-1 GNG2 DRD2 DRD4 GNB1 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 GNB2 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY4 SPRY3 SPRY2 SPRY1 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B AKT1 RAC1 HRAS MAP2K7 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD MAP3K6 PRKCA FRS2 FRS3 PIK3CA FGFR4 PIK3C3 FGFR3 PRKCQ FGFR2 FGFR1 RAF1 MAP3K5 MAPK9 MAP2K3 SHC3 MAPK8 MAP3K2 MAP3K3 PRKCZ NRAS MAP2K2;MAP2K1 MAPK10 PLCG2 GRAP MAPK1 PTPN6 PLCG1 MAPK3 RASA4;RASA4B RASA1 RASA2 AKT2 AKT3 PEBP1 SOS1 SOS2 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNB4 GNB5 CALML3 PDC GNGT1 GRK1 RHO CNGA1 PDE6B CALM3;CALM1 CNGA3 PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNAT1 GNG10 GNG2 GNG5 GNG4 GNG8 GNB2 GNB1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT2 BCAT1 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK7 MAPK9 MAPK8 ELK1 YWHAZ PLD2 MAPK10 MAPK1 MAPK15 MAPK3 YWHAE PRKN YWHAB MAPK14 PPP1R8;STX12 PSMB10 MAPK12 PSMA7 PSMA8 CCNE1 PSMB7 YWHAQ PSMB3 SFN PSMB1 NDUFV2 YWHAG SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 PSMA3 PSMA4 TH CCNE2 PSMA1 SLC6A3 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway GNAQ GNB4 GNB3 GNB5 CHRM3 CHRM1 PRKCZ GRIN2C GRIN2B GRIN2D GRIN1 GRIN2A GRIN3A PKN2 PKN3 ITPR1 ITPR2 ITPR3 SLC18A3 PRKCG GNA14 PRKCI GNG10 PRKCH PRKCB GNG5 PRKCE SLC5A7 GNG4 PKN1 GNA11 PRKCD GNG8 PRKCA PLCB4 GNB2 GNB1 PRKCQ OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNB4 OPRD1 GNB3 GNB5 ADCY2 GNAI1 PDYN GNG10 GNG2 PENK GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB2 GNB1 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway PCCB MCEE PCCA MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 NME1 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 DSCAML1 GART RRM2-1 NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway VDR RARA GC F13B RXRA HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway GNAQ GNB4 GNB3 PLCB1 CACNA1E PLCB2 GNGT1 CHRM3 CHRM1 CHRM5 GRM1 ADORA3 ADORA1 RHOA GRM5 CLTCL1 CLTC CLTB DRD1 CLTA DRD5 OPRD1 GNAO1 BDKRB2 GRM3 BDKRB1 GARNL3 CHRM2 GRM2 ARHGEF1 CACNA1B CHRM4 GNRHR GPR45 OPRM1 CACNA1A RASGRP2 SSTR1 RASGRP1 RAP1GAP SSTR2 RASGRP4 RASGRP3 SSTR3 SSTR4 SSTR5 PRKCG ADORA2A PRKCI ADORA2B PRKCH OPRL1 GNG2 PRKCB PRKCE OPRK1 DRD2 PRKCD DRD4 PRKCA PRKCQ GNB1 PRKCZ GNG13 DNAJC27 RAP1B RAP1A ITPR1 ITPR2 ITPR3 GRM4 GNA14 GRM7 GNG10 GRM6 GRM8 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis HSPB1 MAP2K4 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA FRS2 FRS3 PIK3CA PRKD3 PIK3C3 PRKCQ PRKD2 FGFR1 PRKD1 CRYAA;CRYAA2 CRKL RAF1 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ WNT2B NRAS RBPJ PAK1 MAP2K2;MAP2K1 PLCG2 PAK3 LPXN PAK2 MAPK1 PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B WNT5B WNT5A RBPJL NOTCH2 AKT2 AKT3 NOTCH1 NOTCH4 FOS DVL1 DVL2 SOS1 DVL3 SOS2 WNT1 WNT2 FZD1 TCF7L2 WNT10B WNT10A FZD3 FZD2 STAT1 FZD5 RHOC RHOA STAT3 RHOB WNT7B WNT7A SHC1-1 CRK SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DOK2 DOK3 MAP3K1 EPHA3 GRB7 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB MAPK8 ANGPT1 PDGFA DLK1 APC PLD1 TEK PLD2 JUN GRAP NCK2 NCK1 JAK1 RASA1 CTNNB1 F2R DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 NME1 RRM2B NME4-1 NME2 NME3 DTYMK DUT DSCAML1 TYMS ADAT2 RRM2-1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking UNC13B SYT5 SNAP25 UNC13C SYT3 SYT2 RAB3A SYT1 STXBP1 LOC102724488;SYT15 UNC13D SYT7 SYT6 RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 SRF HSPB1 ELK1 EIF4E MEF2D PRKACB-1 MAP2K6 MAP2K4 MEF2C MAPK14 MEF2B;BORCS8-MEF2B TRAF6 ARAF PIK3CB NFATC2 ADCY1 AKT1 RAC1 PRKG1 CREB1 PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA PRKCQ PRKD2 PRKD1 RAF1 PXN PIK3R1 ROCK1 PAK1 MAP2K2;MAP2K1 MAPK1 CDH1 PLCG1 MAPK3 BRAF PTK2 YWHAB GSK3B CXCL8 IRS1 ELK4 FOXO1-1 RPS6KA3 RPS6KA1 ITGB1 PDPK1 FOS SOS1 FOXO3 MAPK7 ITGAV ATF2 MMP3 RHOA STAT3 CASP3 PLAU SHC1-1 CRK SRC CREM CDC42 PTK2B PRKACA-1 GNG2 SLC18A2 PPP3CA BCAR1 GNB1 BCL2 BAX MAP3K14 BCL2L1 MAPK9 MAPK8 LYN JUN CALM3;CALM1 MAPK10 NFKBIA ARRB2 EGR1 GRB2 JAK2 RPS6KB1 CLU RHEB IER3 RPS6 EIF4EBP1 PTGS2-2 CETP ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 CTNNB1 RYR1 RYR2 ELAVL1 RYR3 CD38 GAST NOS1 ITPR1 CCKBR AKT1S1 PPARG HBEGF GUCY2D ODC1 NR2C2 AKAP1 HDAC7 BAD PTPN11 CCK TPCN2 TPCN1 CAMK4 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis PKLR PGAM2 BPGM ENO1 ALDOA ENO2 PFKL GAPDH-1 PKM PGK1 PFKM GPI HKDC1 HK2 HK1 TPI1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway DLL3 DLL4 RBPJL DLK1 NOTCH2 NOTCH3 NOTCH1 MAML1 NCOR2 NOTCH4 NUMB RBPJ CIR1 JAG2 JAG1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis GAD2 CSAD ALDH5A1 GAD1 ABAT FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAS MAPK9 MAP3K5 MAPK8 JUN FASLG MAPK10 CASP7 CASP8 CASP10 FAF1 CASP3 CAPG MAP2K4 LMNB2 LMNB1 SCIN DAXX CASP6 LMNA APAF1 DFFB PARP3 GSN PARP4 PARP1 PARP2 CFLAR CASP9 FADD INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway GNAQ GNB3 PLCB1 PLCB2 PLCD4 PLCD1 MYH13 MYH14 PRKX MYH11 MYH10 MYH7B PRKACB-1 GNAI3 GNAI2 PREX1 CCRL2 PF4;PF4V1-1 GNAO1 ARAF LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 IFNAR1 PIK3CD CCL13;CCL2 PIK3CB C5AR1 NFATC3 FPR1 NFATC2 CCR10 PIK3CG CCR1 XCR1 NFATC4 ADCY6 NFATC1 ADCY5 CXCL10 CX3CL1 AKT1 CCR9 CCR8 RAC1 CCR7 CCR6 CCR5 CCR4 PRKCB CCR3 CCR2 PRKCE RHOG CX3CR1 NFAT5 CAMK2D CCL11 MYLK2 PIK3CA CAMK2A BUB1B-PAK6;PAK6 CXCR5 CXCR4 CXCR6 COL12A1 MYLK3 CCL4L2;CCL4L1;CCL4 MYLK CCL8 ARPC5L CCL5 RAF1 CXCR3 CCL22 CCL21 CCL20 CCL27 CCL26 ACTC1;ACTG2 PRKCZ ROCK1 NRAS PAK1 ACTG1 PLCG2 PAK3 PAK2 MAPK1 PAK5 PLCG1 PAK4 MAPK3 ARPC4 RRAS CXCL8 IFNG ACTA2 ARPC5 IKBKB ACTA1 ACTBL2 ARPC2 CASK ARPC3 AKT2 AKT3 COL20A1 ITGB1 CHUK PDPK1 COL14A1 ARPC1B ARPC1A SOS1 ITGAL CXCR1 CXCR2 ITGB7 RHOC RHOA STAT3 IL2 COL6A2 COL6A1 ACTB-1 SHC1-1 COL6A3 RELA RELB CDC42 ADCY2 PTK2B GNAI1 PRKACA-1 GNG2 NFKB2 JUNB VAV1 JUND JUN GRAP JAK2 KRAS ITPR1 ITPR2 ITPR3 GNA14 GNG10 VWF MYH1 GNG5 PLCZ1 MYH3 GNG4 MYO3B GNA11 MYO3A GNG8 PLCE1 MYH8 MYH9 PLCL1 PLCB3 MYH6 PLCB4 MYH7 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway GDA HPRT1 PNP-1 PRTFDC1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease GAPDH-1 GRIK5 EP300 GRIK1 GRIN2C GRIN2B CASP8 TBP GRIN2D GRIN1 CASP3 MAP2K4 GRIN2A GRIN3A APAF1 ACTB-1 CLTB MAP3K10 TAF4 CDC42 RAC1 MAP2K7 RHOG ARPC5L MAPK9 TUBB1 TUBB2B;TUBB2A ACTC1;ACTG2 TUBB3;TUBB6 JUN CYFIP2 CYFIP1 HIP1 ACTG1 AP2A1 AP2A2 CAPN9 CAPNS1 CAPN6 CAPN7 TUBB4B CAPNS2 CAPN5 ACTR2 CAPN2 TUBB4A;TUBB;TUBB8B;TUBB8 CAPN3 CAPN1 IFT57 DYNC2H1 DNAI2 DYNC1LI1 DYNC1LI2 RHOJ GAPDHS ACTA2 HAP1 TP63 RHOQ ARPC5 ACTA1 DNAH3 DYNC1I2 SP1 ACTBL2 DNAH7 DCTN1 DNAH8 DNAH5 HTT KALRN TP53 CYC1 DYNC1I1 TP73 DYNC1H1 BDNF CREBBP HIP1R GRIK3 CAPN11 GRIK4 CAPN12 GRIK2 CAPN10 DLG4 DNAL4 ARPC1B FOS ARPC1A ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR CS ACLY PKM PC PDHA1 ME1 PCK1 CLYBL T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway IRAK1 MAP3K8 IKBKE TICAM2 MAPK9 IRAK4 MAP2K3 TICAM1 MAPK8 TIRAP IRF3 ELK1 TOLLIP TLR9 TLR8 JUN TLR7 TLR10 MAP2K2;MAP2K1 TLR6 MAP3K7 NFKBIA NFKBIE TLR4 MYD88 TLR3 MAPK3 TLR2 MAPK14 TRAF6 TAB1 IKBKB CHUK ECSIT TANK TBK1 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 CDH3 GNG13 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A PPP3CA PPP3CB AXIN1 ARRB1 ARRB2 HDAC1 CREBBP PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 EP300 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 NFATC1 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PRKCG PCDHGA7 PRKCI PCDHGA5 PRKCH PCDHGA3 PRKCB PCDHA7;PCDHA9 PCDHGA2 PRKCE PCDHGA1 CDHR1 PRKCD CDH10 CDH11 PRKCA CDHR2 CDH12 PCDHGB1 CDH13 PRKCQ CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PRKCZ PCDHB14 PCDHB5-1 PCDHB16 GSK3B SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B SRCAP NLK PPP3R1 HLTF SIAH2 SMARCA5 INO80 FBXW11 SMARCA1 BTRC SMARCA2 SMARCA4 PPP3CC ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 TBL1Y CTNNA1 CTNNA3 CTNNA2 CSNK1A1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 GNG2 CHD1L TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 GNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SAG SMAD1 SMARCD1 TPTEP2-CSNK1E;CSNK1E SMARCD2 CSNK1D SMAD4 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway HPRT1 XDH PNP-1 PRTFDC1 ADA APRT TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPC LIPE METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway GNB4 GNB3 GNB5 CACNA1E PRKX PRKACB-1 PRKAR1B PRKAR1A GNAI3 GNAI2 PRKAR2B PRKAR2A GNAO1 GRM3 CACNA1B GRM2 CACNA1A GNAT2 SNAP25 SNAP23 GNAI1 PRKACA-1 GNG10 GNG5 SNAP29 GNG4 CACNB1 VAMP8 ADCY10 GNG8 VAMP1 VAMP2 STX1A VAMP3 GNB2 GNB1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNB4 GNAO1 GNB3 GNB5 AVP OXT-1 ADCY2 GNAI1 PDYN GNG10 GNG2 GNG5 OPRK1 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB2 GNB1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNB4 GNAO1 GNB3 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GNAI1 CNR1 CACNA1G GRM5 GNG5 GNAI3 GNG4 GNG8 PLCB3 GNB2 GNB1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I PSMC3IP TAF1C TBP RRN3 CAVIN1 TAF1B POLR1B TAF1A UBTF POLR1D TBPL2 TAF8 TBPL1 TTF1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNB4 GNB3 GNB5 GNAL PRKX ADCY2 PRKACB-1 PRKACA-1 GNG10 GNG2 ADRB2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB2 GNB1 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB4 GNB3 GNB5 PRKX PRKACB-1 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A OPRD1 GNAO1 GNAL CREM OPRM1 ADCY2 GNAI1 CREB1 PRKACA-1 GNG10 GNG2 PDYN PENK GNG5 GNG4 GNG8 GNB2 GNB1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway ADRA1B ADRA1A PLCB1 PLCB2 ADRA2C ADRA2B ITPR1 PRKCG PRKCE PRKCD GNA11 PRKCA ADRA2A PLCE1 PLCB3 PLCB4 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA DBT PCCB ACADM MLYCD ACSS1 HIBCH LDHAL6B ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId SLC2A1 NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT UGP2 B4GALT1 CANT1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway NQO1 ABCC1 ABCC2 ABCB1 NOS3 RALBP1-1 AKR1A1 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ABCG2 CBR3 CBR1-1 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT ASNS GLUL ASRGL1 GLS2 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages PRKCA CACNA1D CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS MAPK3 CACNA1C NFKB1 NFKBIA PRKCB ITPR1 PLCB1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D INPP5E ERBB2 PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency RBKS GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS TKT ALDOA FBP1 PGM1 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis ODC1 SMS AMD1 MAT2B SRM MAT2A ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation LDHD HAGH GLO1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 CYP2E1 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis SLC2A1 NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT UGP2 B4GALT1 CANT1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism UPB1 UCKL1 TYMP RRM2-1 DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 QARS1 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 ALDH3A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency UPB1 UCKL1 TYMP RRM2-1 DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis TYR DCT PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone GNGT1 PRKACB-1 GNB1 CREB1 FSHR ADCY2 CGA GNAS-1 PPP1CA AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT TH DDC GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM PTPMT1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway SLC22A1 ABCC2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins CHRM1 GNGT1 GNAQ GNB1 PLCB1 TUB PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPRS1 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FARSA FARSB LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease G6PC1 PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 GALM-2 ALDOA ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCC1 CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ABCG2 GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation PCCA DBT PCCB SDS DLD BCKDHA BCKDHB MMUT METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1L MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 CYP2D6;LOC107987479;LOC107987478-1 PTGES ADH1C;ADH1B;ADH1A PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 AARS1 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PLA2G2A-1 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A ATP5F1B GAPDH-1 GPD2 UQCRC1 SLC37A4 SLC25A4 SDHC SDHD SDHA SDHB VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism NQO1 VKORC1 GGCX LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN1B CYP1A2 SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway CYP2E1 ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway MVK MVD FDFT1 HMGCR LSS HMGCS1-1 SQLE ACAT1 FDPS IDI1 PMVK BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis AGPAT1 GPD1 PLD2 PTDSS2 CRLS1 PTDSS1 JMJD7-PLA2G4B;PLA2G4B PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 CDIPT CDS1 DGKA CHAT PGS1 GDE1 GPAM LYPLA1-1 PTPMT1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 C3-1 CFP C8A CFB CFD C5 C6 C7 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway ABCC1 ABCC2 ABCB1 PDIA2 UGT1A1;UGT1A6 ABCG2 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 BCHE HYOU1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 TOP1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CES2 CES1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway STAT5A PRKCA STAT5B IRS1 INSR SLC2A4 MAP2K2;MAP2K1 GHR MAPK1 SOCS1 RPS6KA1 RAF1 GRB2 HRAS PTPN6 MAPK3 INS;INS-IGF2 PLCG1 SOS1 JAK2 SHC1-1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 SLC4A1 AQP2 AQP3 ATP6V1B1 SLC14A2 SCNN1G ATP1B3-1 SCNN1D REN CA1 SCNN1B SCNN1A ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD1 GAPDH-1 GPD2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VARS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP10 CASP6 CASP3 LMNA ARHGDIB FADD PAK2 SPTAN1 MAP3K7 DFFB MAP2K4 DFFA DAXX JUN PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 RB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCG2 ABCC1 ABCC2 ABCB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 TUBB1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AARS2 AGXT GPT HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 LTA4H GGT1 PTGDS PTGS2-2 PTGES SLC22A8 SLC22A6 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 PTGIS DNAJB11 GPX1 ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B HYOU1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 AQP1 SLC7A9 SLC4A4 CA1 SLC9A1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway STAT5A EPO FOS ELK1 EPOR MAP2K2;MAP2K1 MAPK8 RAF1 GRB2 HRAS PTPN6 MAPK3 PLCG1 SOS1 JAK2 SHC1-1 JUN CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 AOC3 ALDH2 GAD1 CNDP1 DPYD ABAT DPYS ALDH6A1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell PRKCA CACNB1 GLP1R RAB3A ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 CACNA1A RAPGEF4 SLC2A2 GNG2 GNAQ GNB1 PLCB1 ABCC8 CHRM3 CACNA2D2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 PRKACB-1 GNB1 CREB1 GNAS-1 PPP1CA HTR6 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway GRIN2A CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN3A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism SCLY SEPHS2 PAPSS1 MARS1 GGT1 MAT2B CBS;CBSL AHCY MAT2A CTH SLC39A8 METTL6 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 PRKACB-1 GNB1 ADCY2 GNAS-1 PTGDR DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria HGD TAT YARS1 FARSA HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 PAH FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling GNG2 ROCK1 SRF AKT1 ADCY1 GNB1 LPAR4 ITPR1 PLCB1 GNAS-1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD2 CPT2 CROT SLC25A20 ABCD1 PEX11G CRAT PEX13 PEX14 ACSL1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 AKR1D1 HSD17B3 HSD3B1;HSD3B2 CYP19A1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 GAD1 ADSL ASNS ASL ASRGL1 CAD DDO DARS1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HGD MAOA HAAO DBH ALDH1B1 MIF CYP2E1 COMT TYR FAH GSTZ1 DCT ACSS2 ALDH2 CAT ACSS1 ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AARS2 AGXT GPT MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA DBT PCCB ACADM MLYCD ACSS1 HIBCH LDHAL6B CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALE UXS1 GALK1 GCK UGDH GALT UGP2 PGM1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PRKCA AKT1 PIK3R6 PLCB1 PIK3CG VAV1 PLCG1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging SIRT1 NADK NQO1 NPR1 NMNAT1 CLOCK NAMPT NMNAT3 RORA NMNAT2 PPARGC1A CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS FLVCR2 HMOX1 GUSB BLVRA COX10 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 PRKACB-1 GNB1 CREB1 GNAS-1 PPP1CA HTR7 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway SLC6A2 SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 SLC9A1 ATP1B4 FXYD2;FXYD6-FXYD2 ATP1B2 PRKAR1B ATP1B1 UQCR11 CACNB1 PRKAR2B PRKAR2A DLG1 PRKAR1A MCU KCNQ1 PRKACB-1 KCNK1 ALG10;ALG10B SNTB1 GNAS-1 SNTB2 CHRM2 HCN4 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNA3 CHRNB2 CYP2A13;CYP2A6;CYP2A7-1 AOX1 FMO3 CYP2B6 CHRNA4 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis SHMT1 TMLHE SETD7 BBOX1 ALDH9A1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 AGPAT1 GLYCTK AKR1B1 GPD2 ALDH3A1 LIPC PLPP1 LPL PLPP2 GPAM ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA ABCC4 ABCC5 SLC29A1 TPMT SLC28A3 ADK RAC1 SLC28A2 SLC29A2 AOX1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME2 AK2 AK1 NME1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA ABCC4 ABCC5 SLC29A1 TPMT SLC28A3 ADK RAC1 SLC28A2 SLC29A2 AOX1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism LDHA MPST CTNS GCLC CDO1 CARS1 GCLM GOT1-1 CTH MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway PRKCA MAP2K2;MAP2K1 MAPK8 RAF1 HRAS MAPK3 MAP2K4 JUN FOS ELK1 SRF EGFR MAP3K1 GRB2 PLCG1 SOS1 SHC1-1 PRKCB STAT6 JAK1 STAT1 EGF STAT2 STAT3 RASA1 CSNK2A1;CSNK2A3 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1L MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO PDXP ALPL AOX1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway TYMP TYMS CDA SLC28A1 CES1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis AGPAT1 GNPAT AGPS CEPT1 PLPP1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CHST11 BPNT1 SUOX PAPSS2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway PTGS2-2 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME2 AK2 AK1 NME1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation SLC5A1-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 ATP1A2 GCK ATP1B3-1 ATP1A1 SLC2A2 TREH PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB MAOA SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 AOX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC1A4 GLUD1;GLUD2 GPT2 SLC25A22 SLC38A4 SLC2A4 SLC2A2 GPT GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB PGK1 FH DLST PDHB DHTKD1 MPC1 SLC1A5 IDH3B DLAT GPI IDH3A G6PD PGAM2 TALDO1 ENO1 PGD HK2 PDHA1 GAPDH-1 IDH3G RPIA IDH1 PFKL PGLS SDHC SDHD TKT SDHA SDHB GLS2 CS ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR EBP NSDHL ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway MAPK1 MTOR TYK2 JAK1 STAT3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RHOA CASP9 ELK1 CDC42 PIK3CA MAP2K2;MAP2K1 SMAD2;SMAD3 AKT1 RALGDS CHUK RAF1 RALBP1-1 HRAS MAPK3 RAC1 BAD CYCS-1 VAV3 SMAD4 APAF1 FOXO4 BCL2L1 RALA-1 PLD1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis CYP11A1 AGTR1 GNG2 GNAQ GNB1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency RBKS GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS TKT ALDOA FBP1 PGM1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT TH DDC ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria LDHA MPST CTNS GCLC CDO1 CARS1 GCLM GOT1-1 CTH ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNG2 ROCK1 SRF AKT1 ADCY1 GNB1 ITPR1 LPAR5 PLCB1 GNAS-1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling IRS1 INSR SLC2A4 MAP2K2;MAP2K1 AKT1 MAPK8 MAPK1 PIK3R6 RAF1 PIK3CG GRB2 HRAS INS;INS-IGF2 PDPK1 SOS1 FOXO1-1 IRS2 SHC1-1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LARS1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD2 CPT2 CROT SLC25A20 ABCD1 PEX11G CRAT PEX13 PEX14 ACSL1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System DRD1 PRKACB-1 ADCY2 GNAS-1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway PCNA GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 BCL2 CDK1 E2F1 CDKN1A BAX APAF1 RB1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway SERPING1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C1QC CFD C5 C6 C7 C9 C3-1 C8A CFB C1QB C1S C1R C2 MBL2-1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMA4 PSMC6 PSMA1 PSMC3 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 AGPAT1 GLYCTK AKR1B1 GPD2 ALDH3A1 LIPC PLPP1 LPL PLPP2 GPAM GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS TPI1 HK1 ALDOB AKR1B1 PFKL ALDOA FBP1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway PRKCA MAP2K2;MAP2K1 MAPK8 RAF1 HRAS MAPK3 VAV1 JUN FOS ELK1 MAP3K1 GRB2 PLCG1 CD79B SOS1 PPP3CA CD79A SHC1-1 PPP3CB PPP3CC BLNK RAC1 LYN SYK NFATC3 PRKCB NFATC2 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling GNG2 ROCK1 SRF AKT1 ADCY1 GNB1 ITPR1 PLCB1 LPAR1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 GAD1 ADSL ASNS ASL ASRGL1 CAD DDO DARS1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A CHKA PISD PEMT CEPT1 PCYT2 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis ENDOG HMGB2 HMGB1-1 DFFA CASP7 CASP3 TOP2A CAD GZMH;GZMB-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR1B PRKAR2B PRKAR2A GNGT1 PRKAR1A PRKACB-1 GNB1 ADCY10 GNAS-1 PRKACA-1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 KARS1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C3-1 LOC110384692;C4A;C4B_2;C4B C8A C1QC C1QB C1S C5 C1R C6 C2 C7 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS FLVCR2 HMOX1 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS FLVCR2 HMOX1 GUSB BLVRA COX10 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway TOP2B ABCB1 PTGS2-2 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 TOP2A MPO PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL STAT5A SLC22A1 PIK3R1 ABCB1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism HAAO TPH1 ASMT KMO INMT WARS1 ACMSD WARS2 AANAT TDO2 KYNU AFMID CYP1A1 IDO1 ALDH2 CAT AADAT DDC LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis COAGULATION%SMPDB%SMP0000586 Coagulation FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ALDH2 ALDH1B1 CYP2E1 CAT ACSS1 ACSS2 ADH1C;ADH1B;ADH1A MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 AGPAT1 GLYCTK AKR1B1 GPD2 ALDH3A1 LIPC PLPP1 LPL PLPP2 GPAM PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLA GAA LCT HK1 GALE G6PC1 AKR1B1 GLB1 GALT UGP2 B4GALT1 PGM1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR EBP NSDHL TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) HGD TAT YARS1 FARSA HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 PAH VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCG2 ABCC1 ABCC2 ABCB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 TUBB1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) SIRT1 NADK NQO1 AIFM2 CD38 NMNAT1 NAMPT NMNAT3 TP53 NMNAT2 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 SLC38A5 MYCBP-1 ACLY FH DLST GOT2-1 PDHB DHTKD1 SLC1A4 MPC1 SLC1A5 IDH3B DLAT IDH3A PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1B1 SLC12A6 ATP1A4 ATP1A3 SLC12A1 ATP1A2 ATP1B3-1 ATP1A1 REN FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1L MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPRS1 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT TH DDC SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway BCAR1 MAP2K2;MAP2K1 GNGT1 MAPK1 RAF1 HRAS MAPK3 PLCG1 NFKB1 NFKBIA GNAQ GNB1 PXN CXCR4 PIK3C2G GNAI1 CRK PTK2 CXCL12 PTK2B ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway AGTR1 ACE REN AGT DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 AOX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AARS2 AGXT GPT TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAP2K3 ATF1 MAP4K2 CRADD TRADD MAPK8 MAP3K1 TRAF2 CHUK TANK TNF CASP2 RIPK1 MAPK14 MAP2K7 NFKB1 MAP2K6 IKBKB NFKBIA IKBKG MAP2K4 JUN TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 ALDH3A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids CPT2 SLC25A20 HADH HADHB-1 ECHS1 CPT1A ACAA2 ACSL1 HADHA ACADL INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 AOX1 PCSK2 CYP2B6 CHRNA4 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS FLVCR2 HMOX1 GUSB BLVRA COX10 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism MAOA CNDP1 HARS1 CARNMT1 HDC PRMT3 HNMT HARS2 HAL ALDH2 CNDP2 UROC1 FTCD AMDHD1 CARNS1 ALDH3A1 AOC1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 IARS1 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 SLC25A12 SLC25A11 GOT2-1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) UPB1 UCKL1 TYMP RRM2-1 DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SHMT1 SHMT2 MAT2B GNMT BHMT SARDH MAT2A CHDH SLC44A1 SLC44A2 ALDH7A1 MTR-1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 MASP2 C3-1 MASP1 LOC110384692;C4A;C4B_2;C4B C8A C5 C6 C2 C7 MBL2-1 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway TYMP TYMS CDA SLC28A1 CES1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RARS1 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 AOC3 ALDH2 GAD1 CNDP1 DPYD ABAT DPYS ALDH6A1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria PC MPC1 ME1 PDHA1 ACLY SLC25A11 MDH1 PDHB CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway RYR2 KCNE2 ADRA1A KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB-1 HSD17B10 ECHS1 ACAA2 HADHA MECR PPT1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency UPB1 UCKL1 TYMP RRM2-1 DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells CSF2 PRKCA NRAS FCER1A FYN MAP2K2;MAP2K1 PDK1 MAPK8 MAPK1 FCER1G IL13 PLA2G4A RAF1 HRAS IL4 IL3 IL5 KRAS LCP2 MS4A2 LAT MAP2K4 VAV3 MAP2K3 PIK3CA PIK3R1 AKT1 TNF GRB2 PLCG1 INPP5D MAP2K7 MAPK14 SOS1 MAP2K6 RAC1 LYN SYK GAB2 BTK DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 GAD1 ADSL ASNS ASL ASRGL1 CAD DDO DARS1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism CSAD GAD1 CDO1 GGT6 ADO SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA ABCC4 ABCC5 SLC29A1 TPMT SLC28A3 ADK RAC1 SLC28A2 SLC29A2 AOX1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation BTG2 CHAF1A HOXB9 CCND1 BTG1 PRMT1 NGF FGF1 TP53 RB1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium KCNQ4 KCNQ5 PRKG1 GUCY1B1 NOS3 ADCY10 GUCY1A2 TRPC7 GUCY1A1 TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway CMPK1 SLC22A3 ABCC1 SLC22A1 PGK1 CHPT1 PCYT1A ABCC2 ABCB1 DCK ABCC4 NME1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A2 ABCG2 ABCC3 PCYT2 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway SLC6A2 SLC6A4 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALE UXS1 GALK1 GCK UGDH GALT UGP2 PGM1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP2C9;CYP2C19 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway TOP2B ABCB1 PTGS2-2 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 TOP2A MPO PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A1 PNP-1 SLC2A4 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) HGD TAT YARS1 FARSA HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 PAH HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine SARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling GNG2 ROCK1 SRF AKT1 ADCY1 GNB1 ITPR1 PLCB1 LPAR2 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway FGFR1 SLC10A2 KLB FGF19 NR1H4 FGFR4 FGFR3 FGFR2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell GCG SNTA1 CACNB1 SNTB1 ABCC8 SNTB2 CACNA1A SLC2A2 CACNA2D2 SCN5A FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS TPI1 HK1 ALDOB AKR1B1 PFKL ALDOA FBP1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD2 CPT2 CROT SLC25A20 ABCD1 PEX11G CRAT PEX13 PEX14 ACSL1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin PTGIR MYL3 MYLK GNGT1 PRKACB-1 GNB1 ADCY2 GNAS-1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 TAB2 TAB1 TLR6 RELA TLR5 TLR4 MAPK8 TLR3 MYD88 TLR2 MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 IKBKB NFKBIA TRAF6 IKBKG LY96 ECSIT IRAK1 CD14 TIRAP TLR1 TOLLIP TLR9 TLR8 TAB3 TLR7 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway ABCC1 ABCC2 ABCB1 PDIA2 UGT1A1;UGT1A6 ABCG2 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 BCHE HYOU1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 TOP1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CES2 CES1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis PANK1 ENPP1 VNN1 PPCS PPCDC COASY METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway RBKS GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS TKT ALDOA FBP1 PGM1 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine MAP2K2;MAP2K1 MAPK8 MAPK1 PAK1 HRAS ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A RAPGEF2 JUN ARHGEF7 RAPGEF3 ELK1 CDC42 PIK3CA AKT1 GNGT1 PRKACB-1 MAP3K1 RPS6KA1 CHUK CREB1 GNAS-1 MAP2K7 PDPK1 MAP2K6 NFKB1 IKBKB NFKBIA BAD GNB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1L MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA DBT PCCB ACADM MLYCD ACSS1 HIBCH LDHAL6B TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB-1 HSD17B10 ECHS1 ACAA2 HADHA MECR PPT1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 TARS1 RPS23 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALE UXS1 GALK1 GCK UGDH GALT UGP2 PGM1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway RYR2 KCNE2 ADRA1A KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia MAOA CNDP1 HARS1 CARNMT1 HDC PRMT3 HNMT HARS2 HAL ALDH2 CNDP2 UROC1 FTCD AMDHD1 CARNS1 ALDH3A1 AOC1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SLC25A20 ACADM HADH HADHB-1 ECHS1 ACAA2 ACSM1 HADHA ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CHST11 BPNT1 SUOX PAPSS2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 CYP11B1;CYP11B2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 SRD5A1 HYOU1 AKR1D1 HSD17B3 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway KDR FLT1 VEGFA NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 CHKA PISD CEPT1 PCYT2 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 YARS1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism IPPK MIOX PIK3R4 ISYNA1 INPP1 AMBRA1 PIK3CA ITPK1 IPMK INPP4A FIG4 MINPP1 IMPA1 PIKFYVE ITPKA INPP5J PLCD3 PI4KA PIK3C3 VAC14 BECN1 PTPMT1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD HADHB-1 HSD17B10 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 EHHADH-1 ACSM1 ACADSB HADHA CYP2B6 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DARS1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance SLC5A1-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 LCT ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 SLC2A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTA1 SNTB1 SNTB2 SCN5A LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway PRKCA PSEN1 NRG2 EGFR ADAM17 ERBB3 ERBB4 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MAP3K1 PAK1 RALBP1-1 PCNA RAC1 CAP1 PDGFRA CCND1 WASF1-1 MYLK LIMK1 CCND3 CDK5 ACTB-1 RPS6KB1 MYL2 VAV3 CDKN1A CFL1 ARFIP2 PPP1R12B PLD1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis G6PC1 PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 GALM-2 ALDOA METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TNFRSF1B TNFRSF1A TAB1 IL1A RELA MAP3K14 TLR4 MYD88 CAMKK1 FADD UBB;UBC MAP3K7 TRADD MAP3K1 CHUK TNF RIPK1 NFKB1 IKBKB NFKBIA TRAF6 IKBKG IRAK1 CAMKK2 IL1R1 NCOA3 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST HRH2 GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism JMJD7-PLA2G4B;PLA2G4B FADS2 ELOVL4 ELOVL5 FADS1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS FLVCR2 HMOX1 GUSB BLVRA COX10 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 AKR1D1 HSD17B3 HSD3B1;HSD3B2 CYP19A1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism MAT2B ALDH7A1 BHMT PEMT MTR-1 AHCY MAT2A CHDH BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 CARS1 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL STAT5A PIK3R1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC SKP2 CRK TP53 BCL2L1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AARS2 AGXT GPT CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCG2 ABCC2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCB1 IMPDH2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CES2 IMPDH1 CES1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency HGD MAOA HAAO DBH MIF COMT TYR FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 CYBA HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome G6PC1 PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 GALM-2 ALDOA ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell SST CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR AKT1 PIK3R6 PIK3CG INS;INS-IGF2 IRS2 TSC2 TSC1 RHEB EIF4EBP1 EIF4E MTOR SLC7A5 RPS6KB1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling TLR4 IL1B P4HA3 NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 OPRK1 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 PRKACB-1 GNB1 CREB1 GNAS-1 PPP1CA HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism COMT PDIA2 UGT1A1;UGT1A6 CYP1A1 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 HSD17B1 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) CPT2 ACADS ECHS1 ACAT1 ACADM GCDH HADHB-1 ACADVL CPT1A ACAA2 ACSL1 ACADSB HADHA ACADL ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 TAB2 TAB1 RELA TLR4 MAPK8 TLR3 MYD88 TLR2 MAP3K7 MAP2K4 JUN EIF2AK2 PPARA MAP2K3 FOS ELK1 MAP3K1 CHUK MAPK14 MAP2K6 NFKB1 IKBKB NFKBIA TRAF6 IKBKG LY96 ECSIT IRAK1 CD14 TIRAP TOLLIP TLR9 TLR7 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM PTPMT1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PRKCA RELA FYN MAP2K2;MAP2K1 MAPK8 RAF1 PIK3CG HRAS MAPK3 VAV1 LAT UBB;UBC MAP2K4 JUN CD3G CD3E CD3D FOS ELK1 RASGRP1 ZAP70 PIK3CA PIK3R1 LCK PTPN7 MAP3K1 CD247 GRB2 PLCG1 SOS1 PPP3CA NFKB1 SHC1-1 PPP3CB NFKBIA PPP3CC RAC1 NFATC3 PRKCB NFATC2 NFATC1 CALM3;CALM1 NFATC4 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway GMPS ABCC4 ABCC5 SLC29A1 TPMT SLC28A3 ADK XDH RAC1 PPAT SLC28A2 SLC29A2 HPRT1 AOX1 IMPDH1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA1C CACNA2D2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCA PRKCB P2RY2 PLCG1 PTK2B MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CTH CHDH MSRB2 MSRB3 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) UPB1 UCKL1 TYMP RRM2-1 DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway PRKCA ALDH2 GRIN2A PRKACB-1 CALM3;CALM1 ITPR1 DLG4 NOS1 GRIN1 PPP3CA GRIN3A XDH METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO PDXP ALPL AOX1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency GLUD1;GLUD2 QARS1 GMPS ABAT GOT2-1 GFPT1 GPT PPAT GAD1 ALDH4A1 GSS CPS1 GSR GCLC ALDH5A1 NAGK GCLM GLUL EARS2 GNPNAT1 CAD GLS2 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D INPP5E ERBB2 PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic LDHA MPST CTNS GCLC CDO1 CARS1 GCLM GOT1-1 CTH BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 GPBAR1 NR1H4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids ABCD2 CPT2 HACL1 ALDH2 PHYH-4 SLC25A20 ABCD1 CRAT PEX13 PEX14 ACSL1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome SLC2A1 NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT UGP2 B4GALT1 CANT1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway SLC6A2 ADRA1A SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PCSK2 CHRNA4 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA DBT ALDH2 PCCB ACADM HIBCH ACAA2 ACADSB ACADS HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism GLA ENPP7 PLPP1 ARSA GAL3ST1 CERK SGMS1 SPHK2 GBA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 GLB1 ACER3 DEGS2 KDSR B4GALT6 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11A1 CYP17A1 HSD11B1 HSD11B2 AKR1D1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency MAOA DMGDH ALAS1 SHMT1 SHMT2 GLYCTK GCAT DLD GNMT GARS1 SRR SARS1 PSAT1 SARDH PHGDH GAMT CTH AGXT PSPH ALDH2 SDS GLDC GATM AMT GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production GNGT1 PRKACB-1 GNB1 MC2R GNAS-1 POMC GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 SRF AKT1 ADCY1 GNB1 GNAS-1 LPAR6 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS TPI1 HK1 ALDOB AKR1B1 PFKL ALDOA FBP1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GLUD1;GLUD2 RARS2 GAMT OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis CYP46A1 CYP8B1 CYP7A1 CYP27A1 CYP39A1 CH25H AMACR LIPA ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 HARS1 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency RBKS GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS TKT ALDOA FBP1 PGM1 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway SLC6A2 SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNGT1 PRKACB-1 GNB1 CREB1 ADCY2 CGA GNAS-1 PPP1CA LHCGR LHB LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation SLC5A1-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 LCT ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 SLC2A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency PC G6PC1 SLC2A2 TPI1 MPC1 PANK1 LDHA MDH2 GPI PGAM1 PGAM2 BPGM ENO1 PCK1 HK2 GAPDH-1 SLC37A4 SLC25A11 GALM-2 ALDOA FBP1 PGM1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 AGPAT1 GLYCTK AKR1B1 GPD2 ALDH3A1 LIPC PLPP1 LPL PLPP2 GPAM ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL PGM2L1 HK2 GCK GYS2 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB UGP2 AGL-1 PGM1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis GPD1 LPIN1 AGPAT1 DGAT1 GPAM SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 AOC3 ALDH2 GAD1 CNDP1 DPYD ABAT DPYS ALDH6A1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 DLD ACMSD DLST DHTKD1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 WARS1 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK INPP4A MINPP1 INPP4B IMPA1 ITPKA INPP5J NUDT3 PPIP5K1 IP6K1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway FGB VKORC1 FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II DLD HADH ECHS1 DLST ACAT1 DHTKD1 SLC25A2 AADAT GCDH PIPOX SLC7A2 ALDH7A1 AASS ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA DBT PCCB ACADM MLYCD ACSS1 HIBCH LDHAL6B AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 AKR1D1 HSD17B3 HSD3B1;HSD3B2 CYP19A1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 SLC8A1 AQP2 AQP3 CLCNKA;CLCNKB SLC12A3 TRPV5 ATP1B3-1 ATP4B ATP4A REN ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria GLUD1;GLUD2 GOT2-1 GPT ARG1 SLC1A4 SLC1A5 ASS1 SLC25A12 SLC25A15 CPS1 ASL OTC GLS2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation PRKCA MAPK1 CHUK NOS3 CREB1 MAPK3 NFKB1 IKBKB IKBKG MAPK11 SUCNR1 PLCB1 PTGS1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway CASP9 CASP8 CASP10 CASP3 ARHGDIB CYCS-1 JUN PARP1 PRF1 ARHGAP5 ARHGAP32 CASP1 APAF1 GZMH;GZMB-1 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GPX1 GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 ANPEP OPLAH ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway PRXL2B ALOX5 TBXAS1 JMJD7-PLA2G4B;PLA2G4B CYP2E1 LTA4H GGT1 PTGDS PTGS2-2 PTGES PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX12 CBR1-1 ALOX12B LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RACK1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPS6 RPL22 RPSA RPS3A RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPL5-1 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine HRH2 GNGT1 PRKACB-1 GNB1 CREB1 ADCY2 GNAS-1 PPP1CA DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 AKT1 ADCY1 GNB1 ITPR1 PLCB1 GNAS-1 LPAR3 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate PC SUCLG2 ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) CAMKK2 PATHWAY%WIKIPATHWAYS_20260710%WP4874%HOMO SAPIENS CAMKK2 pathway CHRM3 CRTC2 HFE KEAP1 CPOX TNF IFI44L AQP1 ICAM1 CCND1 CDH1 KDR EP300 MAP1LC3B2;MAP1LC3B-1 RPS6 TSC1 ATP1B2 MID1 CDC25A MAF STIM1 SPINT1 CCNE1 HMBS ULK1 RAF1 SQSTM1 S100A8 PFKFB2 PFKFB3 NEDD4L RASGRP1 HIF1A ACACA PLAC8 CYB5R3 TSPAN8 HMOX1 NLRP1 SLC38A5 PCK2 ABCA1 FIS1 VCAM1 WFS1 NFATC2 ASNS CXCL11 SELL TRPV4 FASN CD28 SPIRE1 CALM1 NFE2L2 MS4A3 SLC2A1 SLC2A4 HK2 HK1 OASL RPTOR MAP1LC3A CCR9 RAC1 NOS1 DNM1L CTSE ERMAP GALNT9 GIT1 SREBF1 PARP1 IL15 MAMDC2 SMC1A WDR35 SIRT1 CREB1 C1QTNF12 FAM20C ARHGEF7 HDAC4 ATP10D TBXT TSPAN33 RELA CAMKK2 PAK1 CCL5 MAPK1 SLC25A21 AHSP MAPK3 TMEM176B IRGC GCK EPOR MTOR KLF1 GATM RPS6KB1 SLCO3A1 CAMK4 RHAG CAMK1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling TP53 HBEGF EGFR MAPK8 BCL2L11 BMF TNF BAK1 MAP2K7 BID MAP2K6 CCND1 MCL1 JUN CDKN2A CFLAR MAPK14 MAPK12 IL2 MAPK13 MAPK11 IL6 BCL3 BCL2 FAS CCNE1 BAX BCL2L1 NFE2L2 RB1 ATF2 CDKN1A FASLG ELK1 FGF7 TNFSF10 CCNA2-1 JUNB MAP3K5 MAP2K3 MAP2K4 PDGFRA HSP90AA1 MMP2 TRAF2 FOS TNFRSF1A IFNG TRAF6 TRAF5 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260710%WP727%HOMO SAPIENS Monoamine transport and regulation NOS1 TNF MAPK14 ACHE TPH2 TGFB1I1 ITGB3 PPP2CB;PPP2CA TNFRSF11B DBH SLC6A1 SLC6A2 SLC6A3 SLC6A4 HRH3 TDO2 UNC13B IL1R1 TSC2 CDC25C FBXO32 SYN1 AGT SCAMP2 RBL2 SLC5A7 ADORA2A TH IL1B AMPH STX1A NECTIN2 CHOLESTASIS%WIKIPATHWAYS_20260710%WP5238%HOMO SAPIENS Cholestasis EPHX1 SLC22A1 NR1H4 HMGCR ABCB11 RXRA SLCO1A2 LDLR TJP2 ABCC3 ABCC4 SCARB1 ABCG8 ABCG5 ABCC2 ATP8B1 SLC10A1 ABCB4 NR1I3 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260710%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL10 CD86 TGFB1 CD80 IL4 IL5 CTLA4 IL2 IL12A VIP CD28 FAS IFNG PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260710%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TUBA8 CDH1 ITGB1 TUBAL3 ROCK1 ROCK2 ARPC1B ARPC1A WAS ARPC5L LY96 WASL CLDN1 ACTG1 CDC42 TUBA1C TUBA1A YWHAQ TUBB1 OCLN-1 NCK2 ABL1 FYN CD14 TUBA3E;TUBA3C-1 NCK1 TUBB2B;TUBB2A PRKCA ARPC4 ARPC5 TUBB4B YWHAZ TUBA4A RHOA NCL-1 KRT18 CTTN ARPC2 ARPC3 TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 HCLS1 CTNNB1 ARHGEF2 TLR5 EZR TLR4 TUBB3;TUBB6 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260710%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway ACE2 NRP1 CTSV;CTSL SLC6A19 TMPRSS4 TMPRSS2 FURIN SCARB1 TLR7 ACAT1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260710%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GOT2-1 SLC25A12 SLC25A22 SLC25A13 GLUD1;GLUD2 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260710%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II TPMT COMT HNMT CYP46A1 HS6ST1 HS6ST2 NAA80 HS6ST3 NDST2 NDST1 AKR7A2 AKR7A3 NDST4 NDST3 CYP1B1 GSTK1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CYP27A1 CYP39A1 CYP2U1 CYP2E1 SULT2A1-4 SULT6B1 NNMT HS3ST3A1 GSTCD MGST3 MGST1 MGST2 GLYAT CYP4F22 CYP19A1 CYP27B1 CYP2B6 CYP4X1 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 GSTM4 GSTM3 EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GSTA3;GSTA1 CYP26A1 CYP27C1 CYP2S1 CYP1A2 CYP1A1 GSTA3;GSTA5;GSTA1;GSTA2 NAT9 GAL3ST1 NAT10 AKR1B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NAT14 HS2ST1 SULT1C3 SULT1C2 CYP26B1 AKR1B15;AKR1B10 CYP4V2 CYP2R1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 UGT2A1 GAL3ST3 SULT4A1 GAL3ST4 CHST8 HS3ST3B1 CHST9 CYP2D6;LOC107987479;LOC107987478-1 NAA30 CHST6 CHST7 GPX4 GSTO2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 GSTO1 GPX5 AKR1A1 KCNAB1 KCNAB2 GSTT2B;GSTT2 KCNAB3 BAAT CYP7B1 INMT NAA40-2 CYP21A2 CHST1 CHST4 NAT8L CHST2 CHST3 CYP2J2-1 NAA20 GSTP1 AKR1D1 CYP2C18-1 CYP7A1 CYP17A1 NAA50-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2F1 GSS GSR CYP51A1 NAT8-2 CYP4B1 FMO1 HS3ST5 FMO2 HS3ST6 FMO3 FMO4 GSTM1;GSTM2-1 HS3ST4 CYP8B1 FMO5 HS3ST1 SULT1B1-1 HS3ST2 GSTZ1 CYP2W1 CYP24A1 GSTA4 CYP11B1;CYP11B2 CYP20A1 EPHX1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260710%WP185%HOMO SAPIENS Integrin mediated cell adhesion RAF1 RAC1 ARHGEF7 PAK1 MAPK1 MAP2K3 MAP2K6 MAPK12 MYLK2 BUB1B-PAK6;PAK6 ITGA2B ARAF CAPN9 CAPNS1 CAPN6 CAPN7 AKT2 ITGB3 AKT3 CAPN5 CAPN2 AKT1 CAPN3 CAPN1 TNS1 SELENOP TLN1 VCL SHC3 PXN PIK3R2 RAP1B RAP1A MAP2K5 VASP CAV3 CAV2 CAV1 BRAF PTK2 ITGA10 ITGA11 GRB2 ITGAM ITGB5 ITGB4 ITGB2 ILK ITGAE ITGAL MYPN ITGAX RAC3 ITGB8 ITGAV ITGB7 ITGB6 HRAS VAV3 ITGA4 PDPK1 ITGA3 ITGA2 ITGA1 VAV2 ITGAD ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 ITGB1 SOS1 CRK DOCK1 ROCK1 ITGA9 ROCK2 SRC MAPK7 MAP2K2;MAP2K1 RHO CSK MAPK6 PAK3 PAK2 CDC42 MAPK4 PAK4 GIT2 SORBS1 MAPK10 CAPN11 CAPN10 ZYX FYN BCAR1 SHC1-1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260710%WP4742%HOMO SAPIENS Ketogenesis and ketolysis SLC16A1 BDH1 SLC2A1 ACAT1 CPT2 OXCT1-1 UCP2 SLC25A20 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260710%WP5355%HOMO SAPIENS Metabolic epileptic disorders MPC2 PHGDH DLAT HADH AASS PSPH GAMT TPI1 ARG1 PGAM1 ACAT1 PGAM2 GOT2-1 AMT SLC25A15 BTD PKM GLUD1;GLUD2 ETHE1 ALDOC ALDOB SLC25A5 ALDOA ALDH7A1 DLD FBP1 MOCS1 FBP2 GCDH ECHS1 GLS2 SHMT2 SHMT1 SLC1A5 SLC7A2 LDHB LDHA HLCS PGK1 ASL PCK1 XDH PDHA1 PKLR MDH1 MDH2 AADAT SQOR SUOX G6PC1 ASS1 LDHA;LDHC PFKL PC SPCS1 CPS1 PSAT1 CTH ACO1 SFXN1 SLC2A1 CDO1 SLC2A4 PFKM HK2 PFKP HK1 LDHAL6B OTC GCK GATM SLC25A1 GOT1-1 GPI MOCS2 MOCS3 GLDC SLC2A2 GPT ENO1 SLC2A5 ENO2 ENO3 GPHN DHTKD1 HK3 GAPDH-1 CBS;CBSL MPC1 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260710%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder TSC1 AKT2 AKT3 AKT1 TSC2 PIK3R2 GSK3B RPTOR PTEN PRKAG1 PIK3CD PRKAG2 UBE3A PIK3CB HRAS GRM1 PRKAG3 SYNGAP1 PRKAB2 PRKAB1 ARC PIK3CA SHANK3 CAMK2B PRKAA1 PRKAA2 PIK3R3 CACNA1C PIK3R1 GRIN2A NRAS EIF4EBP1 NTRK2 HOMER1 BDNF GRIN2C GRIN2B MAPK1 GRIN1 GRIN2D GRIN3B MAPK3 GRIN3A RHEB DLG4 NF1 KRAS MTOR RPS6KB1 CAMK4 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260710%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex RBBP4 TAF1B TAF1C TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 EP400 MTA2 MBD3 CREBBP TAF12 H2BC5 MBD2 H2BC1 EP300 GATAD2B GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 CDK2AP1 H2AB2;H2AB3;H2AB1 MAPK3 PWWP2B CHD4 CHD3 H2AC14 H2BC21 TLK2 UBTF PWWP2A H4C1 H4C6 TBP H4-16 H2AZ2;H2AZ1 KAT2B KAT2A H2AJ POLR1A POLR1B HAT1 POLR1C POLR1D ASF1A ASF1B HDAC2 RRN3 SRCAP HDAC1 TAF1D MTA1 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260710%WP710%HOMO SAPIENS DNA damage response only ATM dependent CCND1 PCK2 G6PC1 GSK3B PTEN PIK3CD RAC1 PIK3CB PIK3CA PIK3R3 PIK3R1 NRAS MAPK1 KRAS CDKN1A FASLG TP53 MAPK8 BCL2L11 BAK1 JUN CDKN2A IRS1 CCND3 CCND2 BCL2 SCP2 PLAU BAX MYC MAP3K7 MAP3K4 PDK1 AKT2 WNT5B AKT3 WNT5A MDM2-2 TCF7 AKT1 PIK3R4 FOXO3 PIK3R5 WNT6 DVL1 SMAD2;SMAD3 DVL2 DVL3 PMAIP1 PIK3R2 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A RBL2 SMAD4 MLKL WNT3A INSR NFKB1 NFKB2 FOSL1 GRB2 BCL6 ATM TP73 WNT2B CDKN1B PIK3C2G PIK3C2A PIK3CG BBC3 PIK3C2B RAC3 PPP2R5E AXIN1 PPP2R5C WNT16 HRAS CAT PIK3C3 SOS2 LEF1 LDLR MAPK9 WNT11 ERBB2 TGFB1 HMGB1-1 TCF7L2 TCF7L1 MAP3K1 BIK BAD WNT7B SOS1 WNT7A APC CCNG2 CDC42 MAPK10 ABL1 SHC1-1 RHOA CTNNB1 ESTROGEN SIGNALING%WIKIPATHWAYS_20260710%WP712%HOMO SAPIENS Estrogen signaling AKT1 MAPK9 JUN PIK3CA MAPK14 ELK1 CREB1 BRAF NFKB1 CHUK BCL2 ESR1 GNAS-1 GNGT1 MAP2K2;MAP2K1 IKBKB PRKACA-1 FOS SP1 MAPK1 GPER1 GNB1 IKBKG ONE CARBON METABOLISM%WIKIPATHWAYS_20260710%WP241%HOMO SAPIENS One carbon metabolism AMT SHMT2 SHMT1 ST20-MTHFS;MTHFS DNMT1 ALDH1L1 MTFMT AHCYL2 AHCY MTRR GLRX MAT2B MTR-1 TYMS FTCD ATIC MTHFD1L DNMT3B DNMT3A MTHFR MAT1A DHFR2;DHFR BHMT FOLH1B;FOLH1 MTHFD1 TCN2 MTHFD2 CHDH GART AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260710%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PHGDH PSAT1 PSPH SLC2A1 SLC7A11 GLS SLC1A5 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260710%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 CHUK RELA IKBKB NFKBIA HMGB1-1 THBD AGER IKBKG DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260710%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 AKT1 FOXO1-1 PHB OMA1 MTOR PHB2 HSPD1 SLC7A7 CLPP TSC2 LARS1 SESN2 LONP1 LONP2 EIF2A ATF4 TSC1 IRS1 MYC TRAP1 GDF15 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260710%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds AXIN1 DVL2 LEF1 WNT1 FZD1 LRP1 CSNK1A1 TNKS FZD7 MBOAT1 APC FZD8 DKK3 SFRP4 TCF4 CTNNB1 GSK3B 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5380%HOMO SAPIENS 5q35 copy number variation KIAA1191 COX6A1 FGF1 IGF1R ARL10 RNF44 UNC5A FBXW7 TPM2 SLC34A1 MYO7B ADAM10 FRS2 COX6B1 HIC2 DOK3 EIF4E1B GPRIN1 PFN3 TMED10 MAX MAGED1 ABHD5 BRCC3 INPP5D GRK6 PLCG1 DRD2 BARD1 PRELID1 PTPRN2 NOP16 HIGD2A FGF19 FGFR4 MXD3 PRR7 COX7B HIP1 COX4I1 FAF2 CLTB DDX41 BRCA1 COX7C BABAM1 BABAM2 UIMC1 NELFB H3-3A KDM6B COX8A TMED2-1 TMED9 EED GAB1 ARFGAP2 CDHR2 PIK3R1 FAM193B CDHR5 B4GALT7 DBN1 RGS14 PTH ABRAXAS1 GNAI3 GRIN2B USH1C CXCR4 GRIN1 COX5B NTN1 COX5A GNAI1 GNAI2 NSD1 LMAN2 RAB24 ZNF346 SNCB PDLIM7 SNCA F12 HIP1R COX6C SIMC1 TSPAN17 ANKS4B PTPN2 PNPLA2 CYP7A1 MAPK8 JUN MYC CAPN3 GRB2 MAPK9 SOS1 SRC MAPK10 ABL1 HK3 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260710%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3AL SYTL1 RAB27A GCC2 RAB27B MYRIP SYTL5 SYTL4 UNC13D SYTL3 SYTL2 RPH3A MLPH MADD TBC1D10A EXPH5 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260710%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 PDIA2 CETP GCK GCKR DGAT2 MTTP SEL1L APOA2 APOA1 LDLR LPL LCAT APOA4 APOA5 LMF1 LIPC APOC2 LRP1 ACSS1 PLTP GPIHBP1 FAS MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260710%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADS HADH CPT2 SLC25A20 PECR HADHB-1 ACADVL CPT1A SLC22A5 SCP2 ACSL1 ECI1 EHHADH-1 ACSL4 ACSL3 ACSF2 HADHA ACADL ACADM PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260710%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 RIPK3 TRADD CASP9 CYCS-1 CASP7 TNF CASP8 CASP3 RIPK1 FADD BIRC3 BAX TRAF2 TNFRSF1A PPP2CB;PPP2CA CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260710%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism MAP1LC3B2;MAP1LC3B-1 IL6 BCL2 ULK1 SQSTM1 WNT5A TNFRSF11B AKT1 BMPR2 CSF1 BHLHE41 WNT10B RORB ARHGAP4 SMAD4 FYCO1 RB1CC1 CTSK LAMP2 TNFSF11 SOST JAK2 ATG3 SERPINF1 ATG10 MEPE DKK1 ATG13 RUNX2 ATG12-1 MAP1LC3A ATG4C CRY1 CLOCK BECN1 WNT16 CALCA NOTCH1 PIK3C3 CTF1 SEMA3A CHRD LRP5 AMBRA1 TNFRSF11A NPAS2 HMGB1-1 TGFB1 ARNTL EFNB2 ATG101 PRKAA2 DRAM2 ATG7 CTHRC1 ATG5 SMAD1 SEMA4D SMAD9 NR1D2 PTH NFATC1 IGF1 SMAD5 BMP6 BMP5 BMP4 BMP3 IL3 PER1 BMP2 ATG16L1 LEP MTOR BHLHE40 PLEKHM1 SP7 VCP-1 TRAF6 TRAP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260710%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome ZG16 TP53 KMT2D INO80E PAXIP1 HDAC3 PCNA KMT2C MVP MAZ GDPD3 MAP2K6 SEZ6L2 CORO1A HIRA PPP4C HIRIP3 CCT8 CDIPT CCT7 CCT5 ALDOA CCT4 BPTF IGBP1 PRRT2 C16orf92 SIAH1 MSN TBX6 C16orf54 CCT6A PPP2CB;PPP2CA TAOK2 REL CCDC6 YPEL3 CASP8 UNC13B NFKB1 PTEN ESR1 MAPK3 DOC2A QPRT NR3C1 CCT6B PAGR1 SPN PPP4R1 PPP4R2 PPP2R1A PPP4R4 CCT3 CCT2 PARP4 UNC13A MAP2K3 IGFBP3 PPP4R3A PPP2R5D PPP4R3B KIF22 TRAF2 TLCD3B ASPHD1 TCP1 KCTD13 EZR TRAF6 TMEM219 PPARG ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALOX5 ALOX15 HPGD ALOX12 CYP2E1 FPR2 LTC4S PTGS1 FADS2 LTA4H GGT1 PTGDS FADS1 PTGIS ELOVL5 ELOVL2 GPR32 PLA2G4A ALOX15B TBXAS1 GSTP1 DPEP1 PTGS2-2 PTGES GSTM4 EPHX2 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism A3GALT2 ST3GAL1 ST3GAL2 ST6GALNAC6 ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 FUT1 B3GALT1 ST8SIA5 ST3GAL5 B4GALNT1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260710%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway SRF RASGRF1 ITPR1 HTR2A PDPK1 ELK4 RPS6KA5 MAP2K6 HTR1E HTR1F PIK3CA STAT3 HTR1D MAP3K1 HTR1A MAPK14 HTR1B CREB1 GNAO1 MAPKAPK3 GNAQ MAPKAPK2 MAP2K2;MAP2K1 GNAI3 MAPK1 MAPK3 GNAI1 RASGRP1 GNAI2 RAP1A ELK1 BRAF RHOA MAP2K3 JAK2 FOS BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260710%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation FXR1-1 ABCB11 SLC10A2 LDLR CYP7A1 ABCG8 FGF19 ABCG5 FGFR4 MAPK1 SLC10A1 MAPK3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260710%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY FFAR3;GPR42 FFAR2 GCG SLC2A4 PPARD KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260710%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway PRKCQ PTPN6 RAC1 CD34 LAT HRAS HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ITPR1 TNF FYN PRKCA PTPN2 PLCG1 GRB2 CSF2 SYK VAV1 IFNG TYROBP LCP2 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD6 SMAD7 FKBP1A SKI BAMBI FBN1 TNF CREBBP JUN EP300 SMAD2;SMAD3 WNT1 SMAD4 NFKB1 RUNX2 ITGB6 HRAS LEF1 MAPK9 TGFB1 STAT3 SMAD1 SMAD9 SMAD5 BMP4 MAPK3 ZFYVE9 SERPINE1 TGFBR1-1 ADAMTSL2 TGIF1-1 JAK1 LEFTY2;LEFTY1 FST FOXH1 TFE3 NOG RUNX3 TGFBR2 TGFBR3 ZEB2 ENG LTBP3 LTBP1 THBS1 ADAMTS10 SPP1 ZNF423 CTNNB1 FOS SKIL EGF IFNG STAT1 LIF INHBA CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260710%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways HMGCR IDI1 MVK MSMO1 SREBF1 HSD17B7 ACAT2 TM7SF2 HMGCS1-1 EBP NSDHL PMVK SC5D HMGCS2 CYP46A1 LBR ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 ACSL1 ELOVL4 NR1H2 ELOVL3 ACSL4 NR1H3 ACSL3 DHCR24 LSS SREBF2 CH25H SQLE CYP27A1 SOAT1 SOAT2 SCD MVD DHCR7 ABCG1 FADS2 ABCA1 FADS1 ELOVL5 ELOVL2 FASN CYP51A1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260710%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2-2 PTGS1 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MOCS2 XDH MTARC2 MOCS1 AOX1 GPHN SUOX NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260710%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer NRP1 EGFR KDR CCNE1 AKT2 AKT3 REL AKT1 SMAD2;SMAD3 GSK3A FLT1 CHD2 CHD1 CDH5 CCN2 SLC39A4 SMAD4 HGF MMP9 CCNE2 PTK2 PECAM1 NFKB1 MET NFKB2 RELB PLXNA2 PLXNA1 PLXNA4 TGFB2 CDKN1B TGFB3 VEGFA COL1A1 COL1A2 CDK2 SNAI1 SNAI2 RAC1 SEMA3A SRC RELA MAP2K2;MAP2K1 MAPK1 MAPK3 BCAR1 TGFBR1-1 TGFBR2 TGFBR3 MMP2 EGF GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260710%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PMEL ASIP TYRP1 ADCY4 ADCY2 ITPR1 ARRB1 ARRB2 PRKACB-1 GNA15 MLANA PRKCB MITF TYR POMC GPR143 CREB1 PLCB3 PLCB4 ADCY9 GNAQ MC1R DCT PLCB1 PLCB2 GNAS-1 PRKACA-1 SERPINF1 VEGFA GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260710%WP100%HOMO SAPIENS Glutathione metabolism GSTA3;GSTA5;GSTA1;GSTA2 GSTT2B;GSTT2 GSTM1;GSTM2-1 GGT1 GGT5 G6PD GPX1 IDH1 OPLAH GSS GCLC GPX4 GSR GSTA3;GSTA1 ANPEP GCLM FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260710%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ALDH1A1 ALDH1L1 ADH5 CYP2E1 MTR-1 CBS;CBSL CEBPB CREB1 MTHFR RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260710%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ACE2 NOS1 TNF CYP24A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ROCK1 MAPK1 KLK1 NPR1 KNG1 CPN1 SERPINE1 BDKRB2 BDKRB1 PRKG1 F12 ACE VDR NOS3 AGT IL1A AGTR1 SERPING1 REN AGTR2 RHOA KLKB1 IL1B NFKB1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260710%WP2596%HOMO SAPIENS Gastric acid production VIP GRP PGA4;PGA3;PGA5 CBLIF SCT GAST CCK PGC MUC6 IL4 SIGNALING%WIKIPATHWAYS_20260710%WP395%HOMO SAPIENS IL4 signaling CEBPA CBL IL2RG SOCS3 SOCS1 FLNA STAT6 SOCS5 STAT5A STAT5B PTPN11 FES EP300 MAPK14 MAPK11 IRS1 AKT1 PIK3R2 INPP5D NFKB1 GRB2 JAK2 PIK3CD PIK3CA STAT3 IL4 BAD SOS1 PIK3R1 CHUK RELA IKBKB MAPK1 MAPK3 CEBPB PTPN6 RPS6KB1 SHC1-1 JAK1 ATF2 ELK1 IRS2 JAK3 FOS NFKBIA IL4R GAB2 STAT1 TYK2 DOK2 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260710%WP2001%HOMO SAPIENS miR targeted genes in adipocytes LPL TMED10 CAP1 FADS1 PHC2 ELOVL5 HIPK3 IGF2R TMEM43 TGFBR2 CSRP1 SRSF10 PICALM SRSF9 CYP1B1 CEBPB OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP3941%HOMO SAPIENS Oxidative damage response PCNA TNF BAK1 MAP3K1 BAD MAPK13 CDKN1C BCL2 C1QB C1S C1R C5AR1 C2 C5 BAG4 C3AR1 CDC42 MAP3K9 LOC110384692;C4A;C4B_2;C4B CR2 APAF1 GADD45A MAPK10 CASP9 TNK2 CYCS-1 TRAF1 TNFRSF1B TRAF3 CASP3 TDP2 NFKBIE C1QC CDKN1A NFKB1 MAP2K4 CDKN1B TRAF2 TRAF6 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL17A TNF IL10 TGFB1 IL4 IL5 IL12A IL2 IL6 CCL5 CSF2 CCL13;CCL2 CXCL8 IL25 LGALS3 LGALS1 CXCL5;CXCL6 IL12B CCL20 MMP9 REG4 IL1B IL13 VEGFB LGALS9C;LGALS9;LGALS9B CXCL2;CXCL3;CXCL1-1 VEGFC VEGFD TGFB2 CXCL12 TGFB3 IL23A VEGFA IL17F IL17D IFNG IL17C CCL28 IL17B PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260710%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS CTSV;CTSL PCNA CDKN1C ITGB3 AKT1 TLN1 VCL WNT1 PLCG1 PTK2 ITGB4 CDKN1B ILK DKK1 SCARB2 ITGAV SMARCAL1 PTPRO MKI67 NOTCH1 CDH2 DAG1 PLCE1 SYNPO ITGA3 LRP5 KIRREL3 TRPC6 KIRREL2 TGFB1 CD80 MME PLAUR CAMK2B KRT8 ACTN4 DNM1 PAX2 ITGB1 CD2AP INF2 COL4A4 COL4A3 COL4A5 MYH9 IRF6 LMX1B UTRN LAMA5 CLDN1 CD151 LRP6 VTN PODXL JAG1 YWHAQ LAMB2 CR1L;CR1 PARVA MYO1E LIMS4;LIMS1 FYN NPHS1 NPHS2 WT1 NCK1 FAT1 VIM AGRN CDKN1A CTNNB1 TLR4 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases SCARB2 ARSA HEXB GBA HEXA LIPA NEU2 GALC NEU3 NEU4 NPC1-1 GM2A GLB1 NPC2 PSAP NEU1 GLA ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260710%WP1993%HOMO SAPIENS Angiogenesis overview TIMP2 TIMP4 NRP1 F2 MMP14 MAPK8 GRB14-1 GRB7 PLA2G1B IQGAP1 PTK2B VHL MAP2K6 SLIT2 PTPN11 SEMA4A KDR ANGPT1 BMX MAPK14 NOX4 TEK FGFR1 MAPK11 MAP3K7 FGF1 RAF1 AKT1 FRS2 PXN MMP9 PLCG1 GRB2 VEGFA PIK3CD RAC1 DAG1 SEMA3A PDPK1 BAD SOS1 CRK APC SRC WAS MAP2K2;MAP2K1 PAK1 MAPK1 CDC42 KRAS MTOR SHC1-1 NCK1 PRKCA NOS3 ATF2 ELK1 MAP2K4 MMP2 ROBO4 PLXND1 SHB ROBO1 DOK2 MEVALONATE PATHWAY%WIKIPATHWAYS_20260710%WP3963%HOMO SAPIENS Mevalonate pathway HMGCR MVD FDPS MVK ACAT2 HMGCS1-1 PMVK KALLMANN SYNDROME%WIKIPATHWAYS_20260710%WP5074%HOMO SAPIENS Kallmann syndrome AKT1 FRS2 PTPN11 PIK3CA FGFR1 MYRF CHD7 LHB ANOS1-1 SEMA3E GRB2 OLIG2 ASCL1 SOX10 MAP2K2;MAP2K1 PROKR2 FGF8 TMEM98 MAPK1 PROK2 PLXND1 GNRH1 OTX2 NEUROG1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAPL2 TP53 WDR45B ATG16L1 GABARAP TNF PTK2B RB1 ATG101 RB1CC1 PTK2 MAP3K5 ULK1 TRAF2 ATG13 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260710%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMP2 SMAD6 SMAD1 SMURF1 TOB2 BMPR1B TOB1 BMPR1A BMPR2 RUNX2 SMAD4 NOG HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260710%WP186%HOMO SAPIENS Homologous recombination MRE11 RPA1 BRCA2 RAD54B RAD52 POLD3 POLD4 RAD50 RAD51 POLD1 POLD2 NBN ATM UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260710%WP4925%HOMO SAPIENS Unfolded protein response TP53 ATF6 MBTPS2 BCL2L11 PMAIP1 BID ATF4 IL1B PPP1R15A MBTPS1 BCL2 XBP1 HSPA5 NFE2L2 RTCB EIF2AK3 EIF2S1 ERN1 DDIT3 CASP2 BBC3 TXNIP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260710%WP4595%HOMO SAPIENS Urea cycle and associated pathways LDHB FH NOS1 OAT NOS2 ASL PYCR1 ALDH4A1 NAGS ARG1 MDH1 GOT2-1 MDH2 NOS3 SLC25A12 SLC25A15 SLC25A13 GLUD1;GLUD2 GOT1-1 ASS1 CPS1 GPT GLS2 OTC PDGFR BETA PATHWAY%WIKIPATHWAYS_20260710%WP3972%HOMO SAPIENS PDGFR beta pathway MAPK8 SRF HRAS STAT6 STAT5A PDGFRB STAT5B EIF2AK2 RASA1 JUN PRKCB PIK3CA STAT3 MAP3K1 PIK3R1 SOS1 MAP2K2;MAP2K1 RAF1 MAPK3 SHC1-1 JAK1 PRKCA ELK1 PLCG1 GRB2 JAK2 MAP2K4 FOS STAT1 NEUROINFLAMMATION%WIKIPATHWAYS_20260710%WP4919%HOMO SAPIENS Neuroinflammation MAPK8 MTOR NOS2 CHUK RELA NFKBIA JUN ASCC1 FOS MAPK14 TLR4 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260710%WP5603%HOMO SAPIENS Caffeine in myocytes RYR1 RYR2 ACTC1;ACTG2 RYR3 MYH13 TNNI1 TNNI2 TNNI3 MYH11 TPM4 TPM3 TNNC1 TPM1 TNNC2 MYLPF ACTA2 MYH1 ACTG1 ACTA1 MYL6 MYH3 TPM2 MYL1 TNNT1 TNNT2 MYL2 MYL3 TNNT3 MYH8 MYH6 MYH7 ACTB-1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260710%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling VPS16 EGR1 FN1 NFATC3 PRG3 MX1-1 BST2 TNF MOV10 IFI44L TF INTS4 HRG IL21 IL22 CTSZ MAP1LC3B2;MAP1LC3B-1 SRP54 CD3G RPS6 CD3E C8A SERPINA5 IFIH1 MMP25 NKRF C1QBP CCL23;CCL15 SDF2 ULK1 CCR6 CCR5 CTSD CTSB TOMM70 UPF1 PARP2 DUSP1 HIF1A IL18 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 GP1BA ATP13A3-1 IL16 RRM2-1 CCL11 NLRP1 HBD;HBB CCL4L2;CCL4L1;CCL4 CXCR1 OS9 SRP72 CXCR2 IL33 CCL22 GSN CCL21 CASP5;CASP4 MIB1 ITCH PTGS2-2 LRG1 CCL27 CCL26 SRP19 STEAP3 AHR CXCL13 FGF2 DEPTOR RPTOR IL18RAP PMPCB CLCC1 RAC1 TLE3 TLE1 PF4;PF4V1-1 VPS33A GTF2F2 PIAS1 CD8A IFITM3;IFITM2;IFITM1 ADAM9 CCL3L1;CCL3L3;CCL3;CCL18 CARD11 RTN4 CCNB2 CCNB1 TPO IRAK1 PITRM1 G3BP1 G3BP2 NLRP3 EIF4EBP1 NPTX1 MARK2 MDN1 FAM83A NEK9 HSPA8 CCL5 CD163 GGH SELP CXCL10 MAVS RHEB PRKCQ TP53I3 IL7 PTPN6 CD8B;CD8B2 ALB MTOR IL9 CDK1 SERPINE1 HLA-DRA CFH-3 CAMK4 MYD88 LGALS3BP JAK1 CXCL9 TRO SAA2;SAA1 MLST8 LBP FGB FGA TNFSF10 ATP6AP1 TGFBR2 DDX58 JUNB FGG SIGMAR1 LARP1-1 ZAP70 APOL3;APOL4;APOL1;APOL2 IRF3 LCK TRAF2 AKT1S1 FOS BIRC5 TRIM59 STAT1 IFNG IRF9 TRAF6 CRP ITIH4 ITIH3 RAP1GDS1 ERLEC1 MAPK8 CCL8 CCL1 UGGT2 EIF4E NTRK1 BID ATE1 IFNB1-4 CD2 JUN CD4 COL7A1 APOC1 VPS41 TBKBP1 CD247 FAM98A IL6 AGT IL1B NFKB2 IL10 IL4 IL5 IL12A ACTG1 IKBKG CEBPB CPN1 FYN CD14 IL1A ACTB-1 ACE2 CTSV;CTSL C1S C1R TRAF3 CCL13;CCL2 CXCL8 CXCL5;CXCL6 CCL20 IL13 CXCL2;CXCL3;CXCL1-1 CXCL12 IL17A APOA2 APOA1 AKT1 GABARAPL2 CASP9 CASP8 CASP3 JAK2 ATG13 ITGA3 SMAD1 SMAD5 EIF4A2 IFIT1 TBK1 GTSE1 VPS36 VPS18 IL1R2 WDR74 IGLL5;IGLL1 DDIT4 CD226 CFB SKAP1 IGFBP3 CFI CFP TRPM2 BTN3A1;BTN3A3 APOM RRAS APOH HP;HPR VPS11 APOD AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3CD FOXO1-1 PIK3CB PARP1 PIK3CA SIRT1 PIK3R3 TSC1 PHLPP1 PIK3R1 MAPKAP1 PIK3R6 STK11 RICTOR PARP3 PDK1 AKT2 AKT3 IKBKG PARP2 PIK3R4 AKT1 PIK3R5 MTOR TSC2 PIK3R2 MLST8 ATM PIK3C2G PIK3C2A PIK3CG GSK3B RPTOR PIK3C2B TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260710%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF13 TAF8 H4C1 MED27 TAF2 TBP SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260710%WP1455%HOMO SAPIENS Serotonin transporter activity IL1B NOS1 SLC6A4 STX1A IL1R1 TPH2 TGFB1I1 ITGB3 MAOA PPP2CB;PPP2CA SCAMP2 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260710%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG1 CSN2-1 EEF2K PRKAG2 CSN1S1 MTOR EIF4G1 PRKAG3 RPS6KB1 EIF4E PRKAB2 TSC2 EIF4A2 PRKAB1 MLST8 PRKAA1 PRKAA2 CSN3 RPTOR EEF2 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260710%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis RHOA TBXAS1 GNA13 TBXA2R GNA12 ARHGEF1 PTGS1 RETT SYNDROME%WIKIPATHWAYS_20260710%WP4312%HOMO SAPIENS Rett syndrome SMARCA1 TAF1B SMARCA2 SMARCA4 NCOR2 XAB2 NCOR1 TBL1XR1 SYNGAP1 SCN8A IMPDH2 HAP1 SCN2A SMC1A SHANK3 GNAO1 GRIN2A CRK TCF4 GRIN2B CHD4 KDM5B HDAC5 TRRAP SATB2 STXBP1 FOXG1 HTT GPS2 HDAC8 SYNE2 BRAF RHOBTB2 MECP2 CECR2 HIVEP2 GABRD SCN1A SRRM3 GABBR2 MEF2C CDKL5 KCNJ10 HDAC1 EIF2B2 ACTL6B GABRA3 GLYCINE METABOLISM%WIKIPATHWAYS_20260710%WP1495%HOMO SAPIENS Glycine metabolism SHMT2 SHMT1 MTHFR TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260710%WP1471%HOMO SAPIENS Target of rapamycin signaling PRKAG1 RAC1 PRKAG2 FKBP1A HMGCR IDI1 PRKAG3 PRKAB2 PRKAB1 PRR5 PRR5L DDIT4L PRKAA1 RRAGA PRKAA2 RRAGC TSC1 RRAGB RRAGD ULK3 MAPKAP1 ULK2 EIF4EBP1 RICTOR ULK1 CDC42 RHEB AKT1 MTOR RPS6KB1 TSC2 PRKCA MLST8 DDIT4 AKT1S1 RPTOR COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260710%WP5145%HOMO SAPIENS COVID 19 structural coverage map ACE2 NRP1 SLC6A19 APOA1 IGHMBP2 MACROH2A2 MACROH2A1 MRM2 MACROD1 MACROD2 CMTR1 PAIP1 UBB;UBC UPF2 TOMM70 UPF1 AQR ISG15 PARP14 PARP9 MPP5 GDAP2 NLRP12 TAB1 UBA52 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260710%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy CACNA1F CACNG6 CACNG7 CACNG8 LMNA CTNNA1 DMD CTNNA3 CACNG1 CACNA1S CTNNA2 CACNG2 CACNG3 CACNG4 CACNG5 JUP DES ITGA2B ITGB3 TCF7 ITGA10 ITGA11 ITGB5 ITGB4 ITGB8 ITGAV ITGB7 ITGB6 CDH2 DAG1 ITGA4 LEF1 ITGA3 ITGA2 ITGA1 TCF7L2 RYR2 ITGA8 TCF7L1 ACTN4 ITGA7 ITGA6 ITGA5 CACNA1C ITGB1 ITGA9 ACTG1 ATP2A2 SLC8A1 GJA1 SGCD SGCA SGCB EMD SGCG DSP ACTN3 ACTN2 CACNA2D1 ACTN1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB1 CACNB2 ACTB-1 CACNB3 CACNB4 CTNNB1 PKP2 DSG2 DSC2 LAMA2 CACNA1D INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260710%WP4558%HOMO SAPIENS Interferon mediated signaling IFNB1-4 JAK1 PRKCA PIK3CA IFNAR2 IL10RB PIK3R1 IFNGR1 STAT2 IFNGR2 IFNLR1 JAK2 IFNL2;IFNL3;IFNL1 IFNE IFNK IFNAR1 STAT1 IFNG IRF9 TYK2 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260710%WP4753%HOMO SAPIENS Nucleotide excision repair PCNA GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CETN2 XPA XPC POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 RAD23A RPA1 GTF2H1 ERCC5;BIVM-ERCC5 GTF2H3 RAD23B POLD3 GTF2H4 POLD4 DDB2 RBX1 CUL4A POLD1 DDB1 POLD2 POLE4 CDK7 ERCC3 ERCC4 ERCC1 POLE2 RPA3 POLE3 ERCC2 ERCC8 ERCC6 MNAT1 CUL4B 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260710%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb MAPK14 MAPK12 MAPK13 MAPK11 EEF2 EEF2K CALM1 RPTOR CDK2 RPS6KA1 PRKAG1 UQCRFS1 RAB5IF PRKAG2 NDUFS8 UQCRC1 COX7C NDUFS3 UQCRC2 PRKAG3 CDH18 UQCRB PRKAB2 UQCR11 PRKAB1 UQCR10 TRPM7 CYC1 PDZD9 NDUFV1 PRKAA1 CDR2 PRKAA2 NDUFA9 NDUFA4 SDR42E2 VWA3A CALM3;CALM1 MOSMO-1 UQCRQ POLR3E CALM2 MAP2K2;MAP2K1 MAPK1 COX5A MAPK3 MTOR CDK1 RPS6KB1 MLST8 TRAP1 MITOPHAGY%WIKIPATHWAYS_20260710%WP5636%HOMO SAPIENS Mitophagy BNIP3 AMFR HUWE1 MAPK8 PINK1 PHB2 NBR1 TOMM7 RAB5A JUN ATF4 SIAH1 BCL2L1 ULK1 SQSTM1 TOMM70 FOXO3 HIF1A SMURF1 FIS1 EIF2AK3 EIF2S1 MAP1LC3A BECN1 MAPK9 AMBRA1 MITF SRC CALCOCO2 CITED2 TOMM20 RABGEF1 SP1 OPA1 FUNDC1 ARIH1 USP30 USP8 BNIP3L OPTN-1 MAPK10 KRAS ATG9B CSNK2A2 ATG9A TFEB VCP-1 MUL1 TAX1BP1 FKBP8 PGAM5 TBK1 CSNK2A1;CSNK2A3 RAB7B RAB7A TFE3 PRKN USP15 RAB5B TOMM40 NLRX1 RAB5C BECN2 BCL2L13 RHOT1 SAMM50 E2F1 MFN1 TRAF2 MFN2 MARCHF5-1 TBC1D17 CCZ1;CCZ1B TBC1D15 MTX1 COPPER METABOLISM%WIKIPATHWAYS_20260710%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 SLC11A2 ATP7A AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260710%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GLYAT N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5153%HOMO SAPIENS N glycan biosynthesis DPAGT1 B4GALT2 B4GALT3 B4GALT1 TUSC3 MGAT4A-1 MPI GMPPB MAN1A2 GMPPA MAN1A1 ST6GAL1 ALG8 ST6GAL2 ALG9 ALG6 ALG5 ALG2 ALG14 ALG3 MOGS ALG12 ALG1 ALG11 DDOST DPM1 DPM2 DPM3 DAD1 RFT1 MAN1B1 RPN2 RPN1 FUT8 GANAB MAN2A2 MAN2A1 MGAT5 MGAT3 MAN1C1 MGAT1 MGAT2 MPDU1 MGAT5B-1 PMM2 SRD5A3 DOLK MGAT4C MGAT4D DOLPP1 MGAT4B STT3A STT3B ALG10;ALG10B GPI APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260710%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein AKT1 BCL2A1 PTHLH BCL2L12 BCL2L10 BAK1 BCL2L2 BCL2L14 BID BCL2L15 GSK3A BOK MCL1 ITGA6 BCL2L13 BCL2 BAX ITGB4 MYC BCL2L1 AKT2 PIK3CG AKT3 GSK3B BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260710%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PC HLCS ACACA MCCC2 PCCA MCCC1 BTD PCCB ACACB STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260710%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling AMFR IDI1 LPL HMGCS1-1 ACSS1 FDFT1 FDPS NR1H2 LSS SREBF2 AKT1 SQLE ACACA SCD MVD GSK3A MDH1 FASN MBTPS1 SCARB1 PRKAG1 ATF6 MBTPS2 PRKAG2 HMGCR PRKAG3 LDLR SREBF1 PRKAB2 PRKAB1 PIK3CA SIRT1 PRKAA1 MED15 CREB1 PRKAA2 INS;INS-IGF2 YY1 CAMP SEC13 ACLY RBP4 KPNB1 SEC23A SAR1A INSIG2 PRKACA-1 SAR1B INSIG1 SP1 RNF139 SCAP SEC23B SEC31B PPARGC1B FGF21 SEC31A SEC24B MTOR SEC24A SEC24D-1 CDK8 GPAM NFYA-1 LPIN1 SEC24C CYP51A1 PPARG HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260710%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex DNMT1 FOXO3 SMARCA4 CREBBP MCL1 GZMH;GZMB-1 FLT3 GABPB1 DNMT3B EP300 DNMT3A TERF2 SMAD4 ZFX ETV6 GABPA BCL2 ATM BCL2L1 PTEN GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260710%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis ORAI1 GRIA1 GRIA2 SLC1A1 CACNG8 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SDCBP GRIA3 GRIA4 NETO2 CACNG2 SLC6A6 NR4A1 MAP1LC3B2;MAP1LC3B-1 SLC6A8 CPEB3 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 STIM1 GRIK4 GRIK1 AP2A1 GRIK2 AP2A2 CABIN1 GABRR3 GLS2 GRM3 GABRR2 GRM2 GRM5 GABRR1 GRM4 SUMO1 GRM7 GRM6 GABRG3;GABRG2 GRM8 NPTN FFAR1 DLGAP3 SLC32A1 NRG1 C1QL3 C1QL2 PICK1 CAMK2A NRXN3 NWD1 SNX27 ERBB4 GNA11 GABRE UBQLN4 ATAD1 GABRQ GABRA2 GABRP GABRA1 MBD5 SLC12A5 GABRA6 GABRA5 GABRA4 GAD1 SYVN1 LHFPL4 AP2B1 CDH2 GRM1 SNX14 P4HB ARC STAT3 GNAQ GRIN2A HOMER1 GRIN2C GRIN2B MAPK1 GRIN1 GRIN2D GRIN3B GRIN3A MAPK3 DLG4 HDAC1 STAT1 PDIA2 CREBBP PPP2CB;PPP2CA SLC6A1 GABRD GABRA3 EFNB2 PLCB1 SRC MAP2K2;MAP2K1 PRKCA HDAC10 FRMPD3 CRTC1 ABAT ADARB1 GRIP1 ZFYVE27 KIF5C SLC7A11 GLUL SH3GL2 SLC6A13 SLC6A12 GAPDH-1 SLC6A11 GABRG1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer FOXO1-1 ADAM10 CCL1 TNF CD96 NCR1-1 PRF1 CCL4L2;CCL4L1;CCL4 CCL13;CCL2 BMI1 CCL3L1;CCL3L3;CCL3;CCL18 GZMH;GZMB-1 GATA2 PVR ADAM17 FCGR3A;FCGR3B NCR3LG1-1 KLRC4-KLRK1;KLRK1 TIGIT CD226 MYC CCL5 CSF2 IFNG IL6 SIGNALING%WIKIPATHWAYS_20260710%WP364%HOMO SAPIENS IL6 signaling RAC1 SOCS3 CREBBP PTPN11 STAT3 GAB1 BAD VIP PIK3R1 PRDM1 SOS1 NLK IL6 TIMP1 IL6R NCOA1 PRKCD MAP2K2;MAP2K1 NR2F6 BCL2L1 MAP3K7 HCK IRF1 MAPK1 IL6ST VAV1 MAPK3 AKT1 RPS6KB1 SHC1-1 PIK3R2 JAK1 AGT JUNB GRB2 JAK2 MAP2K4 HDAC1 STAT1 CRP GSK3B TYK2 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2876%HOMO SAPIENS Pregnane X receptor pathway FOXO1-1 GSTA3;GSTA5;GSTA1;GSTA2 RXRA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SRC NCOA1 ABCB1 NR1I2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SRPX2 CYP2C9;CYP2C19 NRIP1 UGT1A1;UGT1A6 PPARGC1A NCOA2 NCOA3 PSMC5 DNAJC7 SULT2A1-4 CYP2B6 ABCC3 ABCC4 HSP90AA1 CYP2A13;CYP2A6;CYP2A7-1 ABCC2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260710%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CCL3L1;CCL3L3;CCL3;CCL18 TGFB1 CD4 IL4 IL5 IL12A IL2 IFNGR1 IFNGR2 CCR5 CSF2 CXCR4 CXCR3 CCR7 IL12RB1 CCL4L2;CCL4L1;CCL4 CCR4 CCR3 CCR2 IL12RB2 CCR1 CD40LG IL18R1 IL12B CD28 TGFB2 TGFB3 IL4R IFNG LAC PHE PATHWAY%WIKIPATHWAYS_20260710%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260710%WP2261%HOMO SAPIENS Glioblastoma signaling TP53 MDM4 FOXO1-1 CBL FGFR2 EGFR MAP2K7 MAP2K6 CCND1 CDKN2A EP300 TSC1 FGFR1 IRS1 CCND2 ARAF CCNE1 RAF1 IGF1R AKT2 AKT3 MDM2-2 AKT1 FOXO3 TSC2 PIK3R2 BRCA2 MAP2K5 BRAF PLCG1 MET GRB2 ATM CDKN1B PIK3C2G PIK3C2A PIK3CG CDK2 PTEN PIK3C2B PIK3CD BRCA1 PIK3CB HRAS PDPK1 PDGFRB ERBB2 PRKCB PIK3CA GAB1 PIK3R1 NRAS SRC PRKCD MAP2K2;MAP2K1 MAPK1 MAPK3 PRKCQ NF1 KRAS RB1 PRKCA CDKN1A ERRFI1 PRKCG PRKCI MAP2K3 PRKCH MAP2K4 MSH6 PDGFRA FOXO4 PRKCZ E2F1 ERBB3 PLCG2 CDKN2B CDKN2C CDK6 CDK4 SPRY2 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260710%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL10RB IL10RA IL6 BLVRB STAT2 BLVRA HMOX1 IL10 JAK1 IL1A STAT3 STAT1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260710%WP363%HOMO SAPIENS Wnt signaling NetPath RAC1 AXIN1 GCKR MAPK8 CTBP1 SOX1 LEF1 ARRB2 PIP5K1B LRP5 MAPK9 RYK-1 CSNK1D CCND1 BCL9 PRKCB ROR1 TCF7L2 TPTEP2-CSNK1E;CSNK1E ROR2 PI4K2A CSNK1G1 CSNK1A1 TSC1 NLK APC TCF4 MAP3K7 MAPK1 LRP6 AKT1 MTOR DVL1 DVL2 DVL3 TSC2 GSK3A PRKCA NFATC2 RHOA PRKCG CTNNB1 CDK6 GSK3B PPARG CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260710%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TNF IL21 IL22 CCL23;CCL15 CCR6 CCR5 IL18 CCL11 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR2 IL33 CCL22 CXCL11 CCL21 CCL27 CCL26 CXCL13 IL18RAP CCR9 PF4;PF4V1-1 IL15 CCL3L1;CCL3L3;CCL3;CCL18 TPO IL6R CCL5 CSF2 IL6ST CXCL10 IL7 EPOR IL9 TGFBR1-1 CCR7 IL12RB1 CCR4 CCR3 CXCL9 CCR2 IL12RB2 CCR1 CD40LG FASLG IL18R1 TNFSF10 TGFBR2 TNFRSF1A IFNG LIF INHBA IL10RA CCL8 CCL1 IFNB1-4 CNTFR IL2 CNTF IL1RN IL23R IL6 IL27RA IL36A IL36B FAS ACVR1 IL20RA IL20RB CCR10 NGFR XCR1 TNFSF14 TSLP TNFRSF11B TNFSF15 XCL1;XCL2 IL31RA GDF2 IL36G GDF1 PPBP GDF3 IL1R1 GDF6 GDF5 GDF7 IL1F10 IL22RA1 GDF9 TNFSF4 CD27 TNFSF9 ANP32B NODAL ACKR3-2 ACVRL1 CD40 IL20 MSTN TNFRSF13B IL26 IL24 TGFB2 IL27 TGFB3 TNFRSF13C PRL CX3CL1 EDA2R BMP15-1 CCR8 IL11 TNFRSF12A IL19 IL17RC IL17RB IL17RA CCL14 CXCR5 IL10 CXCR6 CCL19 RELT TGFB1 GDF10 CCL25 IL4 CCL24 IL5 GDF11 IL31 CD70 IL37 IL34 BMP8B CLCF1 NFIC INHA CSF3 CSF3R AMHR2 EPO MPL CXCL17 IL5RA IL1RAP CXCL14 LEPR TNFRSF8 IL13RA2 TNFRSF4 IL13RA1 IL11RA LIFR PRLR EDAR CSF1R CSF2RB IL1A CSF2RA TNFRSF17 IL36RN TNFRSF14 TNFRSF9 INHBB BMP7 INHBC INHBE IL7R BMP10 EDA TNFSF13B GHR AMH TNFRSF18 IL4R TNFRSF19 NGF IL3RA GDF15 LTA TNFRSF25 LTB IL9R IL2RG TNFRSF21 CX3CR1 ACVR1B IL1RL1 IL1RL2 ACVR1C IL21R ACVR2B ACVR2A IL2RA IL2RB ACKR4 LTBR IFNAR2 IL10RB IFNGR1 IFNGR2 IFNLR1 IFNL2;IFNL3;IFNL1 IFNK IFNAR1 TNFRSF1B CCL13;CCL2 CXCL8 IL25 CXCL5;CXCL6 CCL20 IL13 CXCL2;CXCL3;CXCL1-1 CXCL12 IL23A IL17F IL17D IL17C CCL28 IL17B IL17A CXCR4 BMPR1B BMPR1A BMPR2 CSF1 TNFSF11 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TNFRSF11A BMP6 BMP5 BMP4 BMP3 IL3 LEP IL1R2 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260710%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer HRAS SOS2 PARP1 PIK3CA PRR5L TSC1 AR INPP4B PIK3R1 SOS1 TELO2 IRS1 MAPKAP1 NRAS EIF4EBP1 RICTOR ARAF MAP2K2;MAP2K1 RAF1 MAPK1 PDK1 AKT2 AKT3 MAPK3 PARP2 AKT1 KRAS MTOR RPS6KB1 TSC2 MLST8 BRAF GRB2 AKT1S1 DEPTOR RPTOR PTEN REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260710%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IL9R IL2RG EGFR IL10RA SOCS3 MAPK8 CREBBP IL21R IL2RA IL2RB MAPK14 MAPK12 CNTFR IFNAR2 MAPK13 IL10RB MAPK11 PTPRT IFNGR1 MAPKAP1 SETD7 IL27RA TRIM28 IFNGR2 STMN1 RICTOR IFNLR1 PIAS3 DUSP2 IL20RA F2R IL20RB OSMR IFNAR1 MAPK15 PTPRD PTPRC F2RL2 F2RL3 IL22RA1 JAK2 DEPTOR RPTOR CTF1 PDGFRB MAPK9 PRKCB STAT3 IL6R SRC MAPK7 CSF3R IL6ST MAPK1 MAPK6 MPL IL5RA MAPK4 MAPK3 MAPK10 MTOR IL11RA LIFR JAK1 CSF2RB CSF2RA IL12RB2 MLST8 AGTR1 AGTR2 IL7R PDGFRA GHR AKT1S1 JAK3 TYK2 IL3RA CELL CYCLE%WIKIPATHWAYS_20260710%WP179%HOMO SAPIENS Cell cycle PCNA CCND1 EP300 CDC25A CDKN1C CCNE1 CCNH SMC3 CDC14A CDC14B GADD45A CDC20 CDC23 CHEK2 CDC27 CHEK1 SKP2 SKP1 ANAPC7 CDC25B ANAPC4 ANAPC5 MAD1L1 RBX1 ANAPC1 ANAPC2 E2F4-1 ANAPC13 PRKDC CDK7 CUL1 PKMYT1 ANAPC10 ANAPC11 ORC5 CCNB3 ORC4 ORC6 ORC1 ORC3 RAD21 GSK3B ORC2 SFN ZBTB17 GADD45B PLK1 CDC7 CDC6 GADD45G STAG1 STAG2 CDC16 ATR YWHAE MCM7 SMC1A CCNB2 YWHAB CCNB1 PTTG1;PTTG2 YWHAG YWHAH SMC1B CCNA1 RBL1 DBF4 TFDP1 ESPL1 TFDP2 MCM3 MCM4 MCM5 MCM6 MCM2 TTK FZR1 CDC45 E2F2 E2F3 BUB3 E2F5 BUB1 CDK1 CDKN2D MAD2L2 WEE1 WEE2 RB1 CDKN1A CCNA2-1 E2F1 HDAC2 CDKN2B CDKN2C CDK6 HDAC1 CDK4 TP53 CDKN2A CCND3 CCND2 MYC MDM2-2 SMAD2;SMAD3 CDC25C RBL2 SMAD4 CCNE2 ATM TGFB2 TGFB3 CDKN1B CDK2 TGFB1 YWHAQ ABL1 YWHAZ GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260710%WP2361%HOMO SAPIENS Gastric cancer network 1 NOTCH1 H3-3A CCNA1 APC MCM4 TOP2A INO80D NUP107 LIN9 AURKA KIF15 H4-16 ESM1 RNF216 RUVBL1 CEP192 MYBL2 ECT2 E2F7 UBE2C ACTL6A TPX2 SMOC2 CENPF S100P GATD3B;GATD3A KIF20B PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260710%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome AHCTF1 TP53 MDM4 NUP188 FMR1 GLE1 HERC2 NUP62 BBS4 EIF4E NUP214 NDC1 SNRPN CCND1 NUP210 NUP133 FSHB CDKN2A NIPA1 TACR3 NIPA2 GABRB3 NUP93 NUP50 FEZ1 FEZ2 LHB POM121;POM121C CCND2 SNURF NUP54 NUP98 OCA2 NUP205 SLC45A2 GABRR3 MAGEL2 SEH1L GABRR2 NUP58-2 GNRH1 DLX5 MDM2-2 TUBGCP2 GABRR1 RNF8 ATP10A AAAS NUP160 NHLH2 GABRG3;GABRG2 NUP42 NUP85 TPR NDN NUP43 NUP88 MSX1 CGA RAE1 RANBP2 NUP155 NUP153 OXT-1 KISS1 GHRH TUBGCP5 UBE2N GABRD TUBGCP6 NUP35 MKRN3 TUBGCP3 GHRL TUBGCP4 NUP37 GABRA5 UBE3A CDC6 TYR POMC INS;INS-IGF2 SEC13 BDNF RB1 NUP107 PRKCZ E2F1 CDKN2B CDKN2C NGF CDK6 PCSK1 CDK4 CYFIP1 GABRG1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260710%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy FGFR2 MAPK8 TNF MAP2K7 MAP2K6 FZD1 MAPK14 RAF1 IGF1R AKT2 WNT5A AKT1 DVL1 HDAC5 PIK3R2 NRG1 MAP2K5 AGT WNT3A NFKB1 CDK7 CALM1 FGF2 PLA2G2A-1 PIK3CG GSK3B MYLK3 MYLK NPPB PIK3CD PPP3CA RAC1 PPP3CB NPPA PIK3CB IKBKE EDN1 CTF1 CISH PDPK1 CAMK2D LRP5 GATA4 HDAC9 HDAC7 PRKCB PIK3CA EIF2B5 TGFB1 FZD2 STAT3 MYEF2 NFATC4 CDK9 PIK3R3 RCAN1 MAP3K14 PIK3R1 HDAC4 ROCK1 CHUK ROCK2 PLCB2 MAPK7 MAP2K2;MAP2K1 IGF1 IKBKB IL6ST MAPK1 LRP6 IKBKG MAPK4 MAPK3 MTOR TAB1 PRKG1 RHOA MAP2K3 MAP2K4 CTNNB1 EGF LIF HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260710%WP4540%HOMO SAPIENS Hippo signaling regulation FGFR2 EGFR NTRK1 CDH1 KDR TEK FGFR1 IGF1R NGFR TCF7 SMAD2;SMAD3 FLT1 CDH5 INSR MET GNA11 FGFR4 PRKAG1 RAC1 PRKAG2 CDH2 PRKAG3 CDH18 LEF1 PDGFRB PRKAB2 PRKACB-1 PRKAB1 PRKCB TCF7L2 TCF7L1 PRKAA1 PRKAA2 PLCB3 PLCB4 FLT4 GNAQ CDH9 CDH8 CDH7 PLCB1 CDH6 PLCB2 NTRK2 CDH4 PRKCD GNAS-1 CDH3 TEAD1 GNAI3 PRKACA-1 TEAD2 TEAD3 TEAD4 PRKCE MST1 CDC42 LATS1 LATS2 PRKCQ GNAI2 PRKAR1B PRKD3 PRKAR1A MTOR CDH10 CDH11 KIT CDH12 CDH13 CDH15 CDH16 CSF1R PRKCA CDH17 FLT3 CDH19 EPHA2 STK3 YAP1-1 CDH20 RHOA PRKAR2B PRKAR2A PRKCG CDH22 PRKCI CDH24 PRKCH WWTR1 GNAL PDGFRA NF2 PRKCZ FGFR3 CTNNB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260710%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 MSTN BACE1 PSENEN APP NCSTN PSEN2 MAPT SIRT1 PSEN1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260710%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway EGLN1 PRKAG1 TP53 CUL3 HIF1A LDHA PDHB ACACA KEAP1 PDHA1 SLC11A2 PRKAB1 PRKAA1 ACACB RPS6 NFE2L2 SLC2A1 VEGFA PDK1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260710%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2B6 FMO3 AOX1 CYP2A13;CYP2A6;CYP2A7-1 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260710%WP5061%HOMO SAPIENS Fatty acid transporters FABP9 ACSL6 ACSL5 FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 ACSBG1 CD36 ACSBG2 SLC27A4 ACSL1 ACSL4 ACSL3 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260710%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMB2 FN1 ITGB6 ITGA1 TNXB LAMA4 SDC2 LAMC1 ITGA11 THBS2 COL3A1 ITGB5 THBS1 COL5A1 COL4A2 COL4A1 COL5A3 COL6A2 COL6A1 COL1A2 COL5A2 COL6A3 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260710%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis INS;INS-IGF2 PCSK2 SLC2A1 GCG PCSK1 GLP1R ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260710%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway FOXO1-1 CBL CAP1 TSC1 FBP1 RAF1 MAP3K9 IRS4 CBLC CBLB RPS6KA4 RPS6KA3 PCK1 RPS6KA6 SESN3 RPS6KA2 MAP3K8 MAP3K6 SLC16A2 SHC2 MAP3K10 G6PC1 MAP3K13 MAP3K11 MAP3K12 CYP2B6 THRB THRA FASN GYS1 FLOT1 FLOT2 MAP4K1 MAP4K2 EXOC7 SLC2A1 MINK1 SLC2A4 SLCO1C1 ANGPTL8 RHOQ MAP4K5 GSK3B RPTOR MAP4K3 RPS6KA1 MAP4K4 PRKAG1 MAP3K2 PIK3CD MAP3K3 PRKAG2 PTPN1 RPS6KB2 PIK3CB TRIP10 PRKAG3 PRKAB2 SREBF1 RPS6KA5 PRKAB1 PIK3CA PRKAA1 PRKAA2 PIK3R3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PIK3R1 EIF4EBP1 MAPK1 MAPK3 RHEB MTOR RPS6KB1 MLST8 MAP3K5 MAP2K3 MAP2K4 CYP7A1 MAPK8 EIF4E MAP2K7 LPL MAP2K6 MAPK14 MAPK12 MAPK13 MAPK11 IRS1 MAPKAP1 RICTOR MAP3K7 MAP3K4 NR1H3 AKT2 SREBF2 AKT1 PIK3R4 FOXO3 SCD SHC3 TSC2 PIK3R2 GSK3A MAP2K5 INSR ABCG8 ABCG5 PIK3C2G PIK3C2A PIK3CG HRAS PIK3C3 RXRA SOS2 PDPK1 MAPK9 RAPGEF1 MAP3K1 INS;INS-IGF2 MAP3K14 SOS1 CRK MAPK7 MAP2K2;MAP2K1 MAPK6 MAPK4 MAPK10 SHC1-1 IRS2 CILIARY LANDSCAPE%WIKIPATHWAYS_20260710%WP4352%HOMO SAPIENS Ciliary landscape ECHS1 CAMK2A CALM1 EXOC7 RAC1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 SMC4 DCAF7 PSMD8 PSMD7 CEP97 IFT80 ARMC8 DYNC1LI1 AFG3L2 IFT88 IFT81 CD2BP2 INTU CTBP2 COPS7B COPS7A IQGAP2 IQGAP3 AAR2 CTSA BBS2 BBS1 EXOC6B BBIP1 AIMP1 EHD3 WNK1 RANBP10 MKS1 GDI1 MYL6B HSPB11 NEFL BBS9 RB1 TNKS1BP1 NEFM TMED1 BBS7 BBS5 RAB8A ZYG11B NUDC CNOT6L EXOC8 EIPR1 IFT140 RAB3IL1 NME8 EXOC4 EXOC3 HDAC2 EXOC6 EXOC5 MAPRE2 HDAC1 EXOC2 PAFAH1B1 EXOC1 DYNC1I2 WDR26 SSNA1 DYNLT2B EXOSC7 PGRMC2 EXOSC4 CREBBP EXOSC9 EXOSC2 DYNC1H1 WHRN RANBP9 UBE2D3;UBE2D2 LRPPRC TIPRL-2 MKLN1 TTC8 PSMC6 GID4 PSMC4 GID8 YPEL5 DGKE EFTUD2 MAEA APMAP ARHGDIA RAB2A LZTFL1 MSH2 TTC30A;TTC30B ERF ANKS6 ARL8B DDX5 PSMD12 PSMD13 HTRA2 SPATA7 DVL3 CDH23 NEK8 TFAP2A UBE2H TFAP2C TFAP2D RHBDD2 UQCC1 NEK7 IFT122 FUZ CNOT10 NFKB1 LSM4 COPS4 IFT20 COPS3 COPS6 IFT22 COPS5 CNOT1 COPS2 LCN2 IFT27 DYNLRB2 DYNLRB1 TFAP2E;TFAP2B COPS8 CNOT9 DOCK5 TTC26 ZMYND19 MCM8 MCM9 MCM10 RPGR IFT52 IFT57 SNAP29 CEP290 IQCB1 EIF5B RBM14 DYNLT1 ARFGAP3 APC IFT43 TBC1D4 RABEP2 EFHC2 IFT46 CCDC40 RALB VPS4A AGPAT2 EHBP1 RMND5B RAB21 IFT74 RMND5A DNPEP STOM SNRPB2 DCAF11 RNGTT NDUFA5 LCA5 RAB14 MFAP1 VAPB XPNPEP3 CLUAP1 CTNNB1 H3-3A MCM7 CDR2 NDUFA9 MCM3 MCM4 MCM5 USH1C MCM6 MCM2 WEE1 COX6C VIM GLB1 GLA BBS4 IQGAP1 NUP133 POM121;POM121C ACSL3 NUP88 MYL6 YAP1-1 CBS;CBSL LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP5171%HOMO SAPIENS Leukotriene metabolic pathway ALOX5 LTC4S LTA4H GGT1 ABCC1 ALOX5AP DPEP2 DECR2 PTGR1-1 DECR1 DPEP1 GGT5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260710%WP206%HOMO SAPIENS Fatty acid omega oxidation ALDH1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A1 ADH4 CYP2E1 ADH1C;ADH1B;ADH1A ALDH2 CYP2D6;LOC107987479;LOC107987478-1 CYP2A13;CYP2A6;CYP2A7-1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260710%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 CYP11A1 PRDX2 CASP3 BAX HSD3B1;HSD3B2 STAR PARP2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260710%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY6 SYNE1 ADCY5 KIF5B SRF ADCY4 CFL1 HRAS ADCY2 BANF1 TMPO SOS2 SUN1 LEMD3 ADCY10 PLEC TGFB1 TMEM43 LBR ADCY9 SOS1 NRAS MAP2K2;MAP2K1 MAPK1 MAP3K9 MAPK3 KRAS SMAD2;SMAD3 EMD CCN2 SMAD4 SYNE2 RHOA WWTR1 GRB2 TGFB2 ADCY3 TGFB3 ADCY1 SYNE4 ADCY8 ADCY7 SYNE3 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260710%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C18-1 EPHX2 PPARA CYP4F3;CYP4F2;CYP4F12;CYP4F11 PPARG EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260710%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NEK7 PRKAR1B PRKAR2A IL1B PRKAR1A NLRP3 PRKACB-1 RAPGEF3 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260710%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness ZEB1 DICER1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260710%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 MVD PTGS2-2 ABCC4 PTGS1 WNT1 NOS3 PPARA PDK1 VEGFA TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260710%WP619%HOMO SAPIENS Type II interferon signaling SOCS3 SOCS1 NOS2 ICAM1 IFNB1-4 EIF2AK2 PTPN11 CIITA SPI1 IFIT2 GBP2;GBP3;GBP1 REG1B;REG1A IFNGR1 STAT2 TAP1 IFNGR2 CYBB PSMB9 PRKCD OAS1 IRF4 IRF2 IRF1 IRF8 CXCL10 ISG15 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CXCL9 JAK1 IL1B JAK2 STAT1 IFNG IRF9 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DCTN4 DCTN3 YWHAQ CDK5 DISC1 NDEL1 DYNC1H1 YWHAE YWHAB YWHAZ YWHAG YWHAH TH DCTN6 DCTN5 DDC PPP2CB;PPP2CA DCTN2 DCTN1 DBH PAFAH1B1 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260710%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3 CREB3L3 CREB3L4 CD14 CREB3L1 IL10 CREB3L2 CCL13;CCL2 CREB5 ATF4 MAPK14 MAPK12 CREB1 MAPK13 MAPK11 IL1B NFKB1 IL6 NFKB2 RELB RELA REL TLR4 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260710%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 CXCL12 RGS16 MYB PRL KLF2 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260710%WP4331%HOMO SAPIENS Neovascularization processes MAPK8 NOTCH1 MAPK9 TGFB1 KDR ANGPT1 FLT4 SMAD1 SMAD9 RELA SMAD5 CXCR4 MAPK1 MAPK3 REL AKT1 JAG1 HIF1A SMAD2;SMAD3 KIT TGFBR1-1 NOTCH3 NOTCH4 PDGFB DLL4 MMP9 EPHB2 ACVRL1 EPHB4 NFKB1 NFKB2 KITLG RELB TGFB2 CXCL12 TGFB3 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CCND1 PTPN11 TSC1 AR CDC25A RAF1 CHEK2 CHEK1 EIF4E1B CDC25B PRKDC BARD1 FOXA1 ATF1 MAP4K1 CRKL SMARCC1 SPINK1 SMARCC2 ERG FKBP5 BLM NDRG1 RPTOR NOXA1 PTEN F13B KLK3;KLK2 MMP1 PLK1 BRCA1 ARID1A ETV4 ARID1B SMARCD1 SMARCD2 SMARCD3 HSD17B3 ATR HSD17B4 PIK3CA HSD17B1 HSD17B2 STAT3 SPRY1 GAB1 EIF4EBP1 PAK1 MAPK1 MAPK3 RHEB MTOR CDK1 JAK1 RB1 CDKN1A ELK1 MSH6 ACTL6A CYP17A1 E2F1 FOS CDKN2B STAT1 CDK4 SPRY2 TP53 MAPK8 PTK2B HSD17B7 JUN CDKN2A MAPK14 BCL2 RICTOR BAX MYC MSH2 MDM2-2 AKT1 CASP9 SMAD2;SMAD3 CASP8 CASP3 MRE11 TSC2 PXN RAP1B RAP1A RAD50 HGF GRB2 ATM ABCC4 CDKN1B CDK2 ACTL6B SMARCA4 HRAS RASA1 RAPGEF1 BAD SOS1 CRK DOCK1 MAP2K2;MAP2K1 SP1 CPN1 HSD3B1;HSD3B2 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260710%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation DDX58 IKBKE TRAF3 IRF3 IFNB1-4 TBK1 TOMM70 TRAF6 MAVS GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260710%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells INS;INS-IGF2 IL6 SLC2A2 IL6R SLC2A1 GCG GLP1R ANGIOGENESIS%WIKIPATHWAYS_20260710%WP1539%HOMO SAPIENS Angiogenesis TIMP2 AKT1 HIF1A FGFR2 CREBBP FLT1 NOS3 PIK3CA ANGPT1 KDR ARNT MAPK14 TIMP3 TEK PDGFB MMP9 PTK2 PLCG1 SMAD1 SRC PDGFRA VEGFA MAPK1 FGF2 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260710%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY6 ADCY5 ADCY4 ADCY2 ADCY10 ADRA1D ADRB1 ADRB2 ADCY9 ADRA2C ADRA2B ADRA2A ADCY3 ADCY1 ADCY8 ADCY7 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases CETP MTTP APOA2 APOA1 LDLR LPL LCAT ABCA1 LIPC APOC2 ANXA2 PCSK9 SCARB1 LIPG APOE APOB LDLRAP1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260710%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3CD PIK3CB PIK3CA PIK3R3 TSC1 PLCB3 PLCB4 PIK3R1 GNAQ ROCK1 PLCB1 PLCB2 TEAD1 TEAD2 MAPK1 TEAD3 TRIO AKT2 TEAD4 PKN3 AKT3 MOB1A;MOB1B LATS1 PKN2 AKT1 LATS2 PKN1 MTOR TSC2 PIK3R2 YAP1-1 RHOA PTK2 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260710%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC3 HDAC9 HDAC7 ACSS2 HDAC4 ALDH1A1 EHMT2 HDAC6 SLC19A1 AHCY ELP3 CYP2E1 ALDH1A3 ALDH1A2 MTR-1 HDAC5 TYMS ATF2 MTHFR HDAC8 MAT1A KAT2B DHFR2;DHFR HDAC10 ADH1C;ADH1B;ADH1A HAT1 ALDH2 HDAC2 HDAC1 DNA REPLICATION%WIKIPATHWAYS_20260710%WP466%HOMO SAPIENS DNA replication CDC7 PCNA CDC6 MCM10 MCM7 DBF4 MCM3 MCM4 MCM5 MCM6 UBB;UBC MCM2 CDC45 POLE RFC5 RFC3 RFC4 RFC1 RFC2 UBA52 PRIM2 RPA2 PRIM1 GMNN RPA1 CDT1 POLA1 POLA2 POLD3 POLD4 POLD1 POLD2 POLE2 ORC5 RPA3 ORC4 ORC6 ORC1 ORC3 CDK2 ORC2 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders ORAI1 SLC34A1 FGFR2 CCND1 KL CDKN1A GALNT3 DMP1 PHEX CYP27B1 CYP24A1 FAM20C ALPL CYP11B1;CYP11B2 ENPP1 NFKB1 FGF23 NFKB2 ROS1 PTH FGFR3 SPP1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT2 B3GNT5 FUT2 FUT6;FUT5;FUT3 FUT1 B3GALT1 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL11 IL11RA JAK1 STAT3 ZEB1 NFKB1 IL6 IL6R JAK2 RELA SOX4 IL6ST JAK3 SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260710%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 ACE2 TANK CD160 MX1-1 TNF TLR7 IFNB1-4 EP300 IFIT2 IFNAR2 IL6 STAT2 NUP98 IFNAR1 TRADD SMAD2;SMAD3 PPBP CASP8 TRAF3 RIPK1 CCL4L2;CCL4L1;CCL4 FADD CCL13;CCL2 TFAP2A CXCL8 CXCR2 RAE1 CXCL5;CXCL6 CXCL11 NFKB1 CXCL2;CXCL3;CXCL1-1 CXCL12 CXCL13 PF4;PF4V1-1 IFITM3;IFITM2;IFITM1 IL10 CCL3L1;CCL3L3;CCL3;CCL18 TGFB1 IL6R CCL5 CSF2 CXCL17 CXCL10 MAVS TP53I3 CXCL9 JAK1 TBK1 DDX58 LARP1-1 IRF3 AP1G1 TRAF2 HDAC2 DHX58 BSG TRIM25 STAT1 HAVCR2 TRAF6 LAG3 TRAF5 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260710%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD MOGAT3 PIK3CB PGS1 PTDSS1 GPAT4 PTPMT1 PIP5K1A GPAT3 GPAT2 CEPT1 PIK3CA CHKB PCYT2 GK PI4K2A IPMK CDIPT CRLS1 GNPAT GPD1 AGPS PEMT CHPT1 LPIN2 CDS2 GPAM LPIN1 PLA2G2A-1 PIK3CG PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260710%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway IL11 NOTCH1 TF TGFB1 TPO INS;INS-IGF2 CNTF WNT7B IL6 IL6R ALK IGF1 PDGFA FGF1 FGF4 FGF8 EPO NTF4 NT5E BMP4 SHH WNT5A FLT3LG IL3 FGF10 KIT GDF5 WNT1 CSF1R CXCR1 WNT2 LEFTY2;LEFTY1 CSF1 FST NOG PDGFB HGF WNT3A NODAL TNFSF11 KITLG WNT2B TGFB3 DKK1 VEGFA FGF2 EGF INHBA ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260710%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP3 KCNN3 CALM1 ESR1 SP1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260710%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation AKT1 PIK3CD GRK1 EPHB2 LTB4R MTOR PIK3CB CMKLR1 FPR2 PIK3CA PDK1 PIK3CG RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260710%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 FOXO1-1 CLOCK NCOA3 PCNA DDX21 FBL MAFG CREBBP POLR1E ALX1 NPAS2 ARNTL SMAD4 CREB1 IRF2 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling BCL2A1 MMP1 TNF BCL2L2 ICAM1 CCND1 CFLAR IL2 IL6 CHUK RELA IKBKB CSF2 REL EGLN2 BIRC3 CXCL8 MMP3 VCAM1 SELE IL1A BIRC2 CD40LG MMP9 IL1B NFKB1 NFKB2 RELB PTGS2-2 CXCL2;CXCL3;CXCL1-1 MMP2 VEGFA BIRC5 TNFRSF1A TRAF6 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling SOCS1 TNF TLR7 IFNAR2 IFNAR1 SQSTM1 TRAF3 MAP3K8 CCL4L2;CCL4L1;CCL4 CXCL8 IL12B CXCL11 PIK3CD RAC1 PLK1 PIK3CB CCL3L1;CCL3L3;CCL3;CCL18 PIK3CA PIK3R3 IRAK1 PIK3R1 RELA CCL5 MAPK1 SYK CXCL10 MAPK3 PTPN6 MYD88 CXCL9 MLST8 LBP RNF216 MAP2K3 MAP2K4 IRF3 SPP1 FOS STAT1 TRAF6 SMAD6 IRF7 MAPK8 MAP2K7 MAP2K6 IFNB1-4 JUN MAPK14 MAPK12 MAPK13 MAPK11 IL6 MAP3K7 AKT2 AKT3 AKT1 PIK3R5 CASP8 RIPK1 PIK3R2 FADD OTUD5 USP7 TICAM2 FBXW5 CD180 IL1B TRAFD1 NFKB1 TICAM1 NFKB2 CD40 RNF41 SIGIRR BTK RBCK1 IRAK2 CYLD TOLLIP TAB3 TAB2 PIK3CG CUEDC2 TNFAIP3 TREM1 TMED7 SFTPD IRAK3 IKBKE IRAK4 TIRAP CISH TLR1 MBL2-1 PELI1 MAPK9 TLR9 CD86 TLR8 IRF5 CD80 TLR6 ZMYND11 TLR3 TLR2 IL12A RNF31 PELI3 PELI2 TIFA CTNNAL1 CHUK SARM1 MAP2K2;MAP2K1 IKBKB LY96 IKBKG MAPK10 TAB1 CD14 TBK1 NFKBIA TLR5 TLR4 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260710%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response ATF6 BCL2L11 EIF2A ATF4 CALR-1 HSP90B1 NARS1 DNAJB9 UBE2E1 EDEM1-1 PDIA6 WARS1 DNAJC3-1 DNAJB11 ERP27 TRIB3 ATF3 ASNS PPP1R15A XBP1 HSPA5 NFE2L2 EIF2AK3 ERN1 DDIT3 BBC3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260710%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK8 RPS6KB2 PIK3CB EIF4E MAP2K7 MAPK9 RPS6KA5 MAP2K6 PIK3CA MAPK14 RPS6 PIK3R3 PIK3R1 EIF4EBP1 PRKCD MAP2K2;MAP2K1 PRKACA-1 MAPK1 PDK1 AKT2 AKT3 MAPK3 AKT1 MAPK10 EIF4A1 MTOR EIF4G1 RPS6KA4 PIM1 PIM2 EIF4B RPS6KB1 PDCD4 RPS6KA2 EIF4G3 EIF4A2 PIK3R2 PRKCA CSNK2A1;CSNK2A3 MAP2K5 MAP2K3 MAP2K4 PIK3CG RPTOR RPS6KA1 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260710%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine PNMT MAOB GCH1 ASMT DNAJC12 PTS QDPR COMT AANAT DHFR2;DHFR TH SPR PAH MAOA DBH GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260710%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease EFL1 RAC1 CYBA SHCBP1 ARHGAP31 NOTCH1 IBTK EIF6 EOGT SBDS NOX3 TLR9 TLR8 CYBB ESR1 MAPK1 SP1 CDC42 MAPK3 KCNN3 NOTCH4 DLL4 DOCK6 NFKB1 CYBC1 NCF1 NCF2 NCF4 BTK COX4I2 RBPJ CXXC5 DGUOK CHCHD2 C4orf54 BEND6 GTF2I MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260710%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HMBOX1 CDKN1B HIPK1 HIPK2 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260710%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CEBPA NRIP1 FOXO1-1 PPARGC1A LEP MAPK8 RXRA TNF NR3C1 LPIN1 PCK2 CEBPD ADIPOQ CREB1 INSR IRS1 IL6 IRS2 SLC2A4 CEBPB PPARG CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260710%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II ACE CTSD CMA1 REN CTSG NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260710%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification JAG1 NOTCH1 ITGA1 JAG2 LPAR1 DLL4 ALPL PLAT DLL1 SAT1 DLL3 GJA5 MGP CALU FGFR3 SOX6 VEGFA METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer TP53 PDHB DLAT HMGCR LDLR GOT2-1 GLUD1;GLUD2 PKM HMGCS2 ACLY DLD SLC43A1 GLS2 UAP1 ME1 PGM3 SLC1A5 GNPNAT1 SLC16A4 BCKDHA LDHA PDHX SOAT1 GFPT1 KRAS RPIA CS SLC7A5 CARM1 PDHA1 RPE;RPEL1 SLC16A1 BCAT2 MDH1 GOT1-1 GPI PFKL FASN GPT SLC2A1 HK2 HK1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260710%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDNF RARA RARB FREM1 ETV4 FREM2 WNT11 CCND1 TGFB1 ITGA8 SPRY1 GDF11 PAX2 SMAD1 ANOS1-1 BMP5 BMP4 SHH BMP2 BMPR1A RET RARG BMPR2 SIX1 GLI1 FST CELSR1 HOXD11 GLI3 HOXA11 GLI2 SALL1 BMP7 BMPER SIX2 GPC3 EYA1 GRIP1 CRIM1 GFRA1 TGFB2 ETV5 DCN CTDNEP1 VANGL2 FRAS1 MYCN SMO EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260710%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 SCARB1 VDR PPARD PPARA NR1I2 CD36 CYP2C9;CYP2C19 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH CS NMRK2 NONO HSPE1 SLC19A2 MDH2 TFE3 BURN WOUND HEALING%WIKIPATHWAYS_20260710%WP5055%HOMO SAPIENS Burn wound healing TP53 FGFR2 FBN1 TNF ICAM1 IFNB1-4 NOX4 CD3E FGFR1 IL6 BCL2 BAX ACHE AKT1 SMAD2;SMAD3 CASP3 CCL13;CCL2 CXCL8 CXCR2 LGALS1 HGF MMP9 IL1B PECAM1 NFKB1 CXCL2;CXCL3;CXCL1-1 TGFB2 CXCL12 DCN TGFB3 FGFR4 VEGFA COL1A1 COL1A2 SNAI2 MMP1 PDGFRB FOXE1 IL15 HEXD HMGB1-1 TNC F13A1 MMP28 KRT222 SFRP2 S100A6 KRT6B;KRT6C;KRT6A S100A9 TIMP1 CHRNA7;CHRFAM7A SCEL SERPINH1 S100A11 BRD4 AMBP KLF4 CXCR4 SLURP1 LIN28A ACTA1 TPT1 CDK16 MYD88 FST FGFR3 MMP2 EGF TLR4 INHBA PI3K AKT SIGNALING%WIKIPATHWAYS_20260710%WP4172%HOMO SAPIENS PI3K Akt signaling FN1 CCND1 KDR RPS6 TSC1 LPAR1 TNXB LAMA4 LAMC1 THBS2 CCNE1 COL4A2 COL4A1 RAF1 COL6A2 COL6A1 COL6A3 PCK1 PCK2 G6PC1 GYS1 FGF2 RPTOR GSK3B PTEN RAC1 PIK3CD RPS6KB2 PIK3CB PIK3CA TNC PRKAA1 CREB1 PRKAA2 PIK3R3 PIK3R1 NRAS IL6R EIF4EBP1 NTRK2 RELA BDNF MAPK1 SYK MAPK3 TCL1B RHEB TCL1A SGK1-1 IL7 PPP2R1B EPOR KRAS CDC37 MTOR PPP2R2A;PPP2R2D TGFA LPAR2 RPS6KB1 LPAR3 LPAR4 GNG10 PDGFD JAK1 CD19 ATF2 PDGFC IGF2 CDKN1A MLST8 GNG13 FASLG LPAR5 LPAR6 FGF7 COL9A1 COL9A3 COL9A2 GYS2 COL2A1 PHLPP2 RELN PDGFRA THBS1 NTF3 HSP90AA1 SPP1 SGK3;C8orf44-SGK3 OSM CHRM2 CHRM1 EGF FGF3 CDK6 COMP CDK4 FGF5 TP53 FGF6 FGF9 FGFR2 EGFR IBSP TNN TNR BCL2L11 PGF COL4A6 EIF4E EFNA5 NTRK1 EFNA4 CHAD IFNB1-4 FGF20 MCL1 THEM4 FGF22 FGF17 EFNA1 G6PC2 IL2 EFNA3 FGF14 PHLPP1 EFNA2 IRS1 IL6 G6PC3 PIK3R6 CCND3 GNB2 STK11 CCND2 FGF18 BCL2 GNB4 GNB3 MYC GNB5 BCL2L1 FGF13 FGF12 NGFR FGF11 HSP90AB1 ITGB3 PPP2CB;PPP2CA LAMC3 MDM2-2 LAMC2 VWF PPP2R5B FOXO3 PPP2R5A PIK3R5 COL6A6 COL6A5 EIF4E2 ATF6B LAMA1 LAMA3 TSC2 THBS4 THBS3 FLT1 GNG2 GNG5 GNG4 PPP2R3C RBL2 GNG8 ANGPT4 HGF ANGPT2 LAMB3 INSR CCNE2 LAMB4 NFKB1 PPP2R3B MET LAMB1 PPP2R3A PPP2R2C PPP2R2B PIK3AP1 CDKN1B VEGFA COL1A1 PRL COL1A2 PIK3CG CDK2 PPP2R5E PPP2R5C SOS2 IL4 BAD ITGB1 CHUK GNGT1 CSF3 IKBKB CSF3R EPO GNB1 IKBKG PRLR CSF1R PRKCA NOS3 IL7R GHR JAK3 IL4R NGF TLR4 IL3RA LAMA2 IL2RG IL2RA ATF4 IL2RB IFNAR2 F2R OSMR FGF1 IFNAR1 IGF1R CREB3 CREB3L3 CREB3L4 CREB3L1 EIF4E1B CREB3L2 CREB5 MYB PDGFB VEGFB KITLG VEGFC VEGFD FGF19 FGFR4 BRCA1 COL4A4 COL4A3 COL4A5 LAMA5 PKN3 VTN PKN2 PKN1 LAMB2 FGF23 ANGPT1 TEK FGFR1 ITGA2B PDGFA FGF4 FGF8 NTF4 AKT2 AKT3 FLT3LG FGF10 AKT1 CASP9 PIK3R2 CSF1 PTK2 ITGA10 ITGA11 GRB2 JAK2 ITGB5 ITGB4 ITGB8 ITGAV ITGB7 ITGB6 HRAS ITGA4 PDPK1 PDGFRB ITGA3 ITGA2 ITGA1 ITGA8 TLR2 ITGA7 INS;INS-IGF2 ITGA6 ITGA5 FLT4 SOS1 ITGA9 HSP90B1 IGF1 MAP2K2;MAP2K1 IL3 FGF21 KIT EIF4B FLT3 EPHA2 PPP2R1A DDIT4 PPP2R5D FGFR3 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260710%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL17A TNF STAT5A IL12RB1 STAT5B IL22 STAT3 IL12B JAK2 RORC IL23A STAT4 CSF2 IL17F STAT1 IFNG TYK2 TLR4 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGB1 ITGA4 BTK S1PR1 S1PR3 S1PR5 MS4A1 S1PR4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260710%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy PIK3R4 WIPI1 ZFYVE1 ATG16L1 BECN1 ATG16L2 MTOR ATG4A PIK3C3 ATG7 RB1CC1 ATG5 ULK2 ATG3 ATG10 ULK1 ATG13 ATG12-1 MAP1LC3A SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260710%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RASGRP1 KRAS SRF HTR2B HRAS RASGRF1 ITPR1 HTR2A GATA4 ELK4 ELK1 GNAQ MAPKAPK2 NRAS MAP2K2;MAP2K1 RAF1 MAPK1 MAPK3 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260710%WP404%HOMO SAPIENS Nucleotide metabolism PRPS2 PRPS1 RRM2-1 RRM1 ADSL NME2 OAZ1 SRM POLA1 POLB RRM2B IMPDH1 HPRT1 ADSS2 DHFR2;DHFR POLD1 POLG SAT1 MTHFD2 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260710%WP4191%HOMO SAPIENS Caloric restriction and aging AKT1 TP53 PPARGC1A NAMPT MTOR PRKAB2 IGF1 SIRT1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260710%WP3407%HOMO SAPIENS FTO obesity variant mechanism PPARGC1A FTO TBX1 IRX5 IRX3 PRDM16 UCP1 ARID5B T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260710%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 TP53 TNF IFNB1-4 CCND1 JUN CD4 CDKN2A CD3G CD3E TSC1 IL2 CD247 IFNAR2 IL23R RICTOR BAX BCL2L1 RAF1 IFNAR1 PTPRC AKT1 RASGRP1 FOXO3 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 TSC2 IL12B PLCG1 NFKB1 CD28 GRB2 JAK2 IL23A STAT4 DEPTOR GSK3B RPTOR CCL28 PTEN IL17A PIK3CD HRAS ITPR1 PDPK1 CD86 CCL19 CARD11 CD80 IL4 CTLA4 IL12A SOS1 PIK3R1 CHUK RELA NFATC1 MAP2K2;MAP2K1 IKBKB CD3D IRF2BPL MAPK1 PPP3CC GRAP2 IKBKG BCL10 MAPK3 LCP2 MALT1 RHEB PRKCQ ICOS MTOR LAT FYN HLA-DRA IL12RB1 MYD88 IL12RB2 CDKN1A MLST8 IL18R1 ZAP70 LCK FOS NFKBIA IFNG TYK2 LTA NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2064%HOMO SAPIENS Neural crest differentiation HAND1 COL11A2 WNT8A PRTG HDAC3 GBX2 HES1 HES5 PMP22 CDH1 DLL1 DLL3 TCF4 TBX6 MYB NOTCH3 NOTCH4 DLL4 FGF19 FGF2 GSK3B CDH2 HDAC4 CTBP2 HDAC6 COL2A1 HDAC2 HDAC1 FGFR2 FGFR1 OLIG2 ASCL1 MYC SOX10 FGF8 DLX5 NEUROG1 DVL1 DVL2 DVL3 WNT1 HDAC5 TFAP2A MSX1 HDAC8 WNT3A NFKB1 NFKB2 SNAI1 SNAI2 TFAP2E;TFAP2B AXIN1 NOTCH1 HDAC9 HDAC7 MITF TCF7L1 ITGB1 SMAD1 DCT CDH7 CDH6 BMP4 HDAC11 ETS1 MPZ HOXA1 SOX9 SOX5 MSX2 MIA ISL1 HOXB1 NOTCH2 MBP FZD3 PHOX2B GFAP GJB1 TLX2 HDAC10 BMP7 LHX2 LHX1 ID1 LHX5 DMBX1 ZIC1 FGFR3 HEY2 RBPJ FOXD3 OLIG3 CTNNB1 PAX3 OLIG1 AXIN2 RHOB PAX7 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260710%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling MAP3K3 TRADD MAPK8 TRAF1 TNF PDLIM7 IFNB1-4 CXCL8 IRAK1 CCL20 MAP3K14 NFKB1 NFKB2 CHUK RELA HSP90AA1 IKBKB MAP3K7 CCL5 NFKBIA MAPK1 TRAF6 IKBKG PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260710%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA RPE;RPEL1 G6PD TALDO1 PGLS TKT PGD TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260710%WP465%HOMO SAPIENS Tryptophan metabolism CYP1A1 HADH CAT ACAT1 GOT2-1 TPH1 HAAO ACMSD IL4I1 KYNU AFMID AOC1 KMO KYAT3 KYAT1 DLD IDO2 ALDH8A1 IDO1 GCDH TPH2 ECHS1 DDC MAOA TDO2 AOX1 INMT AADAT ASMT AANAT ALDH2 AHR STAT1 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260710%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling EIF4E PRKAB1 ACVR2B ITGB1 IRS1 MAPKAP1 RICTOR IGF1 PLD1 TRIM63 WASL IGF1R PDK1 IGFBP5 NEB AKT1 PPARGC1A MTOR SMAD2;SMAD3 RPS6KB1 FBXO32 MLST8 TNFSF9 NFKB1 MSTN ILK AKT1S1 TNFRSF1A PIK3CG DEPTOR EIF2B2 GSK3B RPTOR PTEN MAP1LC3A GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260710%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCQ PKN1 PPP3CA PPP3CB PRKD3 PRKCB PRKCA ANGPT2 RCAN1 PLCB3 GNAQ PRKCG PRKCI PRKCH PRKCD NFATC1 PRKCZ PPP3CC PKN3 PRKCE PPP3R1 PRKD2 PKN2 PRKD1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260710%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL4 LOXL1 LOXL2 GREM1 MAPK8 BMP1 LOX SMAD2;SMAD3 TGFBR1-1 BMPR1A MAPK9 TGFB1 BMPR2 MAPK14 SMAD4 TGFBR2 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260710%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma HRAS SOS2 STAT3 TSC1 SOS1 NRAS RAF1 PDK1 AKT2 AKT3 RHEB AKT1 KRAS MTOR TGFA EREG BTC TSC2 JAK1 GRB2 JAK2 JAK3 EGF RPTOR TYK2 PTEN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP143%HOMO SAPIENS Fatty acid beta oxidation HADH ACSL6 ACSL5 TPI1 LPL ACAT1 ACSS2 CHKB LIPC GK HADHB-1 ACADVL CPT1A DLD ACSL1 ECI1 GCDH ECHS1 ACSL4 ACSL3 HADHA ACADL ACADM ACADS GK2 LIPF LIPE CPT2 CPT1B GPD2 SLC25A20 CRAT PNPLA2 DECR1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260710%WP1601%HOMO SAPIENS Fluoropyrimidine activity TP53 ABCG2 RRM1 GGH RRM2-1 TYMS CDA DPYS MTHFR TYMP ABCC5 TDG DHFR2;DHFR PPAT FPGS UPP1 TK1 ABCC3 XRCC3 ABCC4 UPB1 SMUG1 UCK1 CYP2A13;CYP2A6;CYP2A7-1 ERCC2 DPYD UMPS SLC29A1 SLC22A7 CES2 CES1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260710%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 LYZ-1 CD68 F3 CD14 CD86 CD163 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260710%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway TP53 EGFR MAPK8 BAK1 CCND1 CDKN2A BUB1B-PAK6;PAK6 ARAF BAX BCL2L1 PLD1 RAF1 AKT2 AKT3 AKT1 GADD45A CASP9 SMAD2;SMAD3 PIK3R2 BRCA2 DDB2 SMAD4 RAD51 BRAF NFKB1 TGFB2 TGFB3 VEGFA RAC3 PIK3CD RAC1 GADD45B RPS6KB2 PIK3CB PEBP1 GADD45G POLK RALBP1-1 MAPK9 RIPK4 RALA-1 ERBB2 DUSP6 PIK3CA TGFB1 ARHGEF6 STAT3 PLD2 RALGDS PAK5 PIK3R3 BAD PIK3R1 CHUK PRKCD RELA MAP2K2;MAP2K1 IKBKB PAK1 RALB MAPK1 PAK3 PAK2 IKBKG CDC42 MAPK3 PAK4 E2F2 E2F3 MAPK10 KRAS MTOR TGFA RPS6KB1 TGFBR1-1 JAK1 RB1 CDKN1A TGFBR2 E2F1 EGF STAT1 CDK6 CDK4 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260710%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy PMP22 RAB3B MTMR2 LRSAM1 RAB3A HSPB8 HSPB1 LITAF FGD4 SH3TC2 RAB25 KIF1B RABAC1 SBF2 EGR2 RAB4A RAB4B GDAP1 RAB11A RAB11B MPZ DNM2 FIG4 NEFL RAB7A MFN2 NDRG1 NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP268%HOMO SAPIENS Notch signaling NCOR2 NOTCH1 CTBP1 HES1 HES5 CREBBP ADAM17 JAG2 DLL1 DLL3 CTBP2 JAG1 DVL1 RBPJL NUMBL DVL2 MAML1 DVL3 DTX1 DTX2 RFNG NOTCH2 DTX3 DTX4 APH1A NOTCH3 LFNG NOTCH4 APH1B INPP5K KAT2B DLL4 PTCRA KAT2A KCNJ5 DTX3L MFNG NUMB MAML3 RBPJ HDAC2 NCSTN HDAC1 PSEN2 PSEN1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260710%WP26%HOMO SAPIENS S1P receptor signal transduction MAPK12 PLCB3 PLCB1 PLCB2 MAPK7 GNAI3 MAPK1 MAPK6 AKT2 AKT3 MAPK4 MAPK3 GNAI1 GNAI2 AKT1 ASAH1 SMPD2 RACGAP1 S1PR2 S1PR1 SPHK2 S1PR3 SPHK1 S1PR5 PIK3C2B RAS SIGNALING%WIKIPATHWAYS_20260710%WP4223%HOMO SAPIENS Ras signaling PTPN11 KDR PLD1 RAF1 IGF1R REL RASGRP1 SHC2 PLA2G4A PLCG1 CALM1 FGFR4 PIK3CD RAC1 PIK3CB RASGRF1 SYNGAP1 PLCE1 RALBP1-1 RALA-1 PIK3CA PLD2 RALGDS GAB1 PAK5 PIK3R3 PIK3R1 GRIN2A CALM3;CALM1 NRAS NTRK2 CALM2 RELA PAK1 GRIN2B MAPK1 GRIN1 MAPK3 NF1 KRAS LAT GNG10 GNG13 FASLG ELK1 RAB5B PRKCG RAB5C ZAP70 PDGFRA FOXO4 PLCG2 CALML6 CALML3 EXOC2 CALML4 ETS2 RASSF1 FGFR2 HTR7 EGFR RASSF5 MAPK8 JMJD7-PLA2G4B;PLA2G4B TIAM1 RIN1 RAB5A PLA2G1B PLA1A NTRK1 SHC4 PLA2G3 RASAL1 RASAL2 PLA2G5 STK4 RASAL3 RASGRP2 TEK PLA2G6 FGFR1 RASGRP4 TTBK1 RASGRP3 ABL2 GNB2 BUB1B-PAK6;PAK6 BRAP AFDN GNB4 GNB3 RGL1 GNB5 RGL2 BCL2L1 RASGRF2 RASA4;RASA4B NGFR PLA2G12A AKT2 PLA2G4F AKT3 PLA2G12B PLA2G4D KSR1 AKT1 PLA2G4E RRAS2 PLAAT3 KSR2 MRAS RASA3 RASA2 SHC3 RAPGEF5 ARF6 PIK3R2 SHOC2 RAP1B FLT1 GNG2 PLA2G10;LOC100652777 RAP1A GNG5 PLA2G2F GNG4 PLA2G2D PLA2G2E GNG8 PLA2G2C INSR NFKB1 MET GRB2 PLA2G2A-1 RAC3 HRAS SOS2 PDGFRB PRKACB-1 MAPK9 RASA1 PRKCB BAD FLT4 SOS1 CHUK GNGT1 MAP2K2;MAP2K1 IKBKB PRKACA-1 RALB PAK3 GNB1 PAK2 IKBKG CDC42 PAK4 ETS1 MAPK10 ABL1 KIT SHC1-1 CSF1R PRKCA FLT3 EPHA2 RHOA FGFR3 RRAS GAB2 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260710%WP2857%HOMO SAPIENS Mesodermal commitment pathway HAND1 CCND1 ACVR2B ACVR2A DLL1 FZD8 TRIM28 C1QBP TCF4 TBX6 CCDC6 ACACA RARG FOXA1 NFE2L2 CUL4B RARB SRF PIAS1 ELK4 NLK CTBP2 KLF4 LEFTY2;LEFTY1 FOXH1 NOG INHBA SMAD6 FGFR1 ACVR1 FGF8 PPP2CB;PPP2CA SMAD2;SMAD3 GDF3 BMPR1A WNT3 BMPR2 HTT SOX21 SMAD4 SOX2 SOX17 WNT3A NODAL SESN1 CEP250 DIP2A RPL38 PITX2 JAK2 EOMES HES7 WDHD1 ZNF281 DKK1 EMSY ADAM19 TWSG1 WDFY2 BCORL1 SNAI1 TOX MACF1 AXIN1 GATA6 POU5F1;POU5F1B GATA3 MBTD1 VAV3 EPB41L5 CHRD UBR5 LEF1 ATP8B2 FZD5 FZD4 PBX3 HMGA2 ZFHX4 TCF7L1 TRERF1 HPRT1 PBX1 EXT1 CCDC88A EXT2 SMAD1 NANOG;NANOGP8 NABP2 TBX1 PLCH1 TRIM71 SETD2 NCAPG2 ARID5B PHF6 TEAD1 PRKACA-1 CSRP2 TEAD2 ZIC2 BMP4 TRIM5 ZIC3 HNF4A JARID2 LATS1 KDM6A SLC2A12 MSGN1 PRKAR1A BHLHE40 TET1 PAX6 PARP8 TOX3 ARL4A DDAH1 AEBP2 MTF2 AHDC1 C9orf72 DNMT3B FOXC2 FOXC1 IQCJ-SCHIP1;SCHIP1 YAP1-1 WDCP ASCC3 BMP7 ZNF462 ELP4 CRTC1 GRHL2 TBX3 MEIS1 KLF5 RGS10 MIXL1 AMH FOXA2 AXIN2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling EGLN1 BNIP3 TP53 BCL2A1 NOS2 EDN1 BAK1 BID MCL1 ANGPT1 ARNT PKM BAX BCL2L1 EPO HIF1A LDHA BNIP3L PGK1 TGFA SERPINE1 PDHA1 PMAIP1 SLC16A1 ANGPT2 PFKL IGFBP3 PTGS2-2 SLC2A1 TGFB3 HIF1AN VEGFA BIRC5 HK1 IGFBP1 IGFBP2 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP558%HOMO SAPIENS Complement and coagulation cascades CLTC CLU C8G F2 SERPINF2 F5 F7 F8 F9 MASP2 MASP1 CFD CPB2 SERPINC1 PLG TFPI LMAN1 C6 C7 PLAT SERPINA5 C9 CD55 F10 SERPIND1 C1QB C3-1 PLAU C1S PROC C1R F2R C5AR1 C2 C3AR1 LOC110384692;C4A;C4B_2;C4B VWF CR2 C1QC F13B F3 PLAUR CR1L;CR1 KNG1 SERPINE1 BDKRB1 CFH-3 F12 SERPING1 FGB KLKB1 CFB CFI THBD SERPINA1 PROS1 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260710%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways PHGDH PSPH AMT CEPT1 CHKB PCYT2 ALDH7A1 PEMT CHPT1 DMGDH AHCYL1 PLD1 CSAD SLC25A48 DNMT3L SHMT2 PCYT1B SHMT1 PCYT1A BHMT2 GPX6 GPX7 MTHFD2L BCAT1 MAT2A CHKA AGXT2 GAD2 BCAT2 SOD3 GNMT SOD1 ETNK2 ETNK1 SARDH PSAT1 CTH CDO1 GAD1 DNM1 GPX1 GCLC GPX4 GCLM GPX5 AHCYL2 AHCY MAT2B MTR-1 BAAT TYMS MTHFD1L DNMT3B DNMT3A MTHFR MAT1A DHFR2;DHFR BHMT MTHFD1 MTHFD2 CHDH GSS GSR CBS;CBSL OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260710%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy FGFR2 IBSP NTRK1 VHL JUN KDR FGFR1 COL3A1 AKT2 AKT3 AKT1 HIF1A COL10A1 CCN2 GANC MMP13 DDR2 EPAS1 ACAN NFKB1 CNMD RELB P4HTM FOSL1 JAK2 JUND FOSL2 FOSB LAMTOR1 FGFR4 VEGFA COL1A1 RUNX2 PIK3CA STAT3 ARNT RELA MAPK1 MAPK3 CEBPB SOX9 PRKCA JUNB FGF23 COL2A1 FGFR3 SPP1 FOS NGF SLC25A46 PATHWAY%WIKIPATHWAYS_20260710%WP5521%HOMO SAPIENS SLC25A46 pathway APOO CHCHD3 CHCHD6 EMC1 DNM1L EMC2 EMC3 EMC4 EMC6 EMC7 EMC8 SLC25A46 MFN1 APOOL MFN2 MMGT1 IMMT OPA1 EMC10 MICOS13 MICOS10 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260710%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCS2 BDH1 ACAT1 HMGCL OXCT1-1 CCL18 SIGNALING%WIKIPATHWAYS_20260710%WP5097%HOMO SAPIENS CCL18 signaling CCR8 ZEB2 CDH2 PTK2B MMP2 AK4-1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260710%WP3298%HOMO SAPIENS Melatonin metabolism and effects CRY1 FOXO1-1 CYP1A2 CLOCK CYP1A1 EDN1 CSNK1D ARNTL TPTEP2-CSNK1E;CSNK1E ECE1 MAP2 SIRT1 PER2 IRAK1 MTNR1A ADRB1 MTNR1B CRY2 ACHE APOE CYP2D6;LOC107987479;LOC107987478-1 MAOA CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP2C9;CYP2C19 PER1 PRKCA ASMT CAMK2A AANAT NFKB1 CALM1 GSK3B TRAF6 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5400%HOMO SAPIENS 6q16 copy number variation LEPR LEP ARNT POMC INS;INS-IGF2 INSR GHSR MC4R NPY NTRK2 AGRP SIM1 BDNF GHRL SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260710%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260710%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk RAC1 SRC SLIT2 VEGFA ROBO4 KDR ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260710%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation UQCRFS1 GSTO1 CAT COA3 AS3MT VDAC1 SOD1 ATP1A1 SDHA ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260710%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma ADCY6 ADCY5 ADCY4 ADCY2 PRKACB-1 CREB1 PLCB3 PLCB4 ADRB2 ADCY9 PLCB1 PLCB2 GNAS-1 PRKACA-1 MYL4 MYL1 PRKAR1B PRKAR1A MYL2 MYL3 NR3C1 PRKAR2A ADCY3 ADCY1 ADCY8 ADCY7 TRANSLATION FACTORS%WIKIPATHWAYS_20260710%WP107%HOMO SAPIENS Translation factors EIF6 EIF4E EIF2AK2 EIF2B5 EIF5B EIF4EBP1 PAIP1 GSPT2 EIF3C;EIF3CL EEF2 EIF4H EEF2K EIF4EBP2 EIF2B1 EIF4A1 EEF1B2-1 EIF4G1 EIF2B4 EIF2B3 EIF4B PABPC1;PABPC3 CLUH EIF2AK1 EIF4G3 EIF4A2 EIF5A;EIF5AL1 EIF2S2 EIF2S3;EIF2S3B EIF1 EEF1A1 EEF1G EIF5 EEF1D EIF1AY;EIF1AX EIF3I EEF1A2 EIF3J EIF3G EIF3H ETF1 EIF3E EIF2AK3 EIF3F EIF2S1 EIF3D EIF3A EIF3B EIF2B2 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260710%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRF7 IKBKE IRAK4 TIRAP TLR1 TLR7 TLR9 TLR8 TLR6 TLR3 TLR2 IRAK1 CHUK RELA IKBKB MAPK1 IKBKG REL TRAF3 MYD88 TBK1 TICAM2 NFKB1 TICAM1 NFKB2 RELB IRF3 TOLLIP TLR5 TRAF6 TLR4 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260710%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases AKT1 LGMN SNCA MAOB NTRK2 BDNF BACE1 APP AKT2 SRPK2 STAT1 PPP2CB;PPP2CA AKT3 SET-1 MAPT CEBPB TARDBP INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260710%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition INSR IRS1 MTOR TBC1D4 RPS6KB1 SLC2A4 AKT2 RPS6 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260710%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways PTPN11 ACVR2B FZD1 FZD7 FZD8 FGF1 RAF1 PDGFB FGF19 FGFR4 FGF2 GSK3B PTEN PIK3CD STAT3 GAB1 IL6ST MAPK1 LRP6 MTOR JAK1 ELK1 NOG FGF7 FGF23 MAP2K3 PDGFRA FOS EGF FGF3 LIF FGF5 FGF6 SMAD6 FGF9 HNF1A SMAD7 FGFR2 FZD6 EGFR FZD9 FGF16 ACTR2 WNT9B ERAS MAP2K6 FGF20 JUN FGF22 FGF17 MAPK12 FGFR1 FGF14 FGF18 ARAF ACVR1 PDGFA FGF13 FGF4 FGF8 FGF12 FGF11 AKT2 WNT5B AKT3 WNT5A MDM2-2 FGF10 AKT1 WNT6 SELENOP DVL1 BMPR1B DVL2 DVL3 BMPR1A PIK3R2 WNT1 WNT2 WNT3 BMPR2 MAP2K5 WNT4 WNT10B WNT10A SMAD4 WNT3A BRAF GRB2 WNT2B AXIN1 WNT16 HRAS PDGFRB LRP5 FZD5 WNT11 FZD4 FZD2 WNT7B SOS1 WNT7A SMAD1 APC SMAD9 MAPK7 MAP2K2;MAP2K1 SMAD5 MAPK6 BMP4 MAPK4 FGF21 LIFR FZD3 FGFR3 CTNNB1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP2571%HOMO SAPIENS Polycystic kidney disease pathway ADCY6 WNT8A FZD6 FZD9 TNF WNT9B FZD10 PKD2 PKD1 CCND1 WNT9A JUN KDR SSTR2 CFTR PDE1A FZD1 WNT8B TSC1 KCNN4 SLC12A2 FZD7 FZD8 STK11 SFRP4 MYC IGF1R WNT5B WNT5A WNT6 DVL1 DVL2 DVL3 TSC2 WNT1 FLT1 WNT2 WNT3 WNT4 WNT10B WNT10A WNT3A BRAF GNA11 VEGFB WNT2B GSK3B RPS6KA1 PRKAG1 PRKAG2 WNT16 HRAS PRKAG3 PRKAB2 PRKAB1 WNT11 FZD5 ERBB2 FZD4 FZD2 PRKAA1 PRKAA2 WNT7B WNT7A GNAQ NRAS SRC GNAS-1 MAP2K2;MAP2K1 IGF1 IKBKB GNAI3 MAPK3 GNAI1 RHEB GNAI2 KRAS MTOR FZD3 PLCG2 CTNNB1 FOS EGF GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260710%WP455%HOMO SAPIENS GPCRs class A rhodopsin like CHRM3 CCR6 CCR5 FPR2 FFAR1 CXCR1 CXCR2 GPR32 CCR9 HTR2A HTR1E HTR1F HTR1D HTR1A HTR1B MTNR1A MTNR1B GHSR MC4R FFAR3;GPR42 FFAR2 CXCR3 CCR7 LPAR4 CCR4 CCR3 CCR2 CCR1 LPAR5 LPAR6 CHRM2 CHRM1 SSTR2 NPFFR2 OXTR NPFFR1 RRH GRPR HTR4 GPR174 GPR173 HTR6 CCR10 EDNRA EDNRB XCR1 GPR171 PTGDR GPR37L1 TRHR GPR161 OR7A10;OR7A17-11 PTGFR OR2AG1;OR2AG2 HRH3 FPR1 TBXA2R OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 NTSR1 NTSR2 GPR17 ADORA2A GPR15 GPR12 ACKR3-2 NMBR HCAR2;HCAR3 OR6A2 GPR18 GPR19 GPR27 GPR25 PTGDR2 GPR21 GPR22 GPR20 NPY4R2;NPY4R OR10H1;OR10H5;OR10H2 BRS3 CCR8 CCKAR OR2B6;OR2B2-1 GPR39 GPR37 HTR2B GPR34 AVPR1B GPR35 OR2H1-1 CXCR5 OR1A1-1 AVPR1A MC3R OR2S2-1 CCKBR ADRB3 FSHR OR1E1;OR1E2 OR3A2 OR3A1 MC1R OPRD1 PTGER4 GPR45 PTGER1 PTGER2 PTAFR PTGER3 CHML P2RY12 P2RY13 GPER1 P2RY10 P2RY11 P2RY14 GPR52 GPR1 OR8D2-1 GPR4 GPR50 GPR3 GPR6 BDKRB2 MAS1 BDKRB1 MC5R F2RL1 OR1C1 GPR68 CHRM4 AGTR1 GPR65 CHRM5 NPY2R AGTR2 GPR63 CYSLTR1 CYSLTR2 ADORA3 CCRL2 ADORA1 OR2D2 LHCGR NPY1R GPR75 OR2T1 APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 GPR87 C5AR2 GPR85 GPR83 MCHR1 CX3CR1 OR1Q1 HRH1 HCAR1 HRH2 DRD1 DRD3 DRD4 OR2B3 DRD5 OPN4 ACKR4 OPN3 OR2F1-2 OR2J1;OR2J2;OR2J3-2 NMUR2 NMUR1 OR14J1 MLNR ADRA1B ADRA1A PRLHR F2R OR7C1;OR7C2-9 PTGIR NPY5R OR2H2 C3AR1 OR1F1 F2RL2 AVPR2 F2RL3 OPRM1 SSTR1 SSTR3 SSTR4 SSTR5 ADORA2B OR10A4 OR10A5 OR2A7;LOC107987545;OR2A4 OPRL1 P2RY6 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CNR2 P2RY4 OR8B8 CNR1 OR2W1 P2RY2 P2RY1 OR12D3 DRD2 OR1D2 OPRK1 HTR5A OR10J1-2 HCRTR2 HCRTR1 OPN1SW ACKR2 OR11A1 ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A CXCR4 HTR7 LTB4R CMKLR1 RHO 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260710%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260710%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis SOCS1 MX1-1 PIAS1 IFITM3;IFITM2;IFITM1 IFIT1 JAK1 PTPN2 IFNAR2 IFNGR1 STAT2 TAP1 IFNGR2 JAK2 OAS1 IRF1 IFNAR1 STAT1 IFI35 IFNG IRF9 TYK2 PSMB8 IFIT3 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260710%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2C9;CYP2C19 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260710%WP4217%HOMO SAPIENS Ebola virus infection in host VPS16 CLTC SOCS3 CTSV;CTSL FLNA BST2 EP300 C1QBP IGF1R CTSB REL HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RFC1 GSN ICAM2 ICAM3 CLTB PIK3CD RAC1 HLA-DOA HLA-DOB VPS39 VPS33A PIK3CB KPNA1 TIMD4 TYRO3 CLEC4G TSG101 SCIN CLTCL1 PIK3CA CLEC6A ADAM17 HLA-DPB1-1 CLTA ACTN4 ASGR1 PIK3R3 HLA-DPA1 RHOC PIK3R1 TOP1 GAS6 MFGE8 HLA-DQB2;HLA-DQB1 CLEC4M;CD209-2 RELA HLA-DMA HLA-DMB PAK1 FLNB FLNC MAPK1 EPS15 DAB2IP MERTK MAPK3 TPCN2 AXL PRKRA NEDD4 RAB9A FOLR1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E HLA-DRA RAB7A DDX58 NPC1-1 IRF3 NPC2 STAT1 HAVCR2 IRF7 EGFR TIAM1 RAB5A IQGAP1 CREBBP VPS41 ITGB3 AKT1 RASA2 PIK3R2 TFAP2A CAV3 CAV2 CAV1 NFKB1 NFKB2 RELB EIF2S1 ITGAV IKBKE ITGA4 MBL2-1 ITGA3 EIF2AK2 ITGA2 ITGA1 VAV2 IL4 ITGA6 ITGA5 ITGB1 VPS4A ACTG1 CDC42 TBK1 VPS18 RHOA ACTN1 ACTB-1 VPS11 RHOB TLR4 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260710%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway WIPI1 BECN1 ATG4A PIK3C3 PRKAA1 ATG101 PLA2G6 ATG7 TSC1 ATG5 STK11 SCP2 ULK1 RHEB PIK3R4 ATG16L1 ACACA MTOR WDR45 DCAF17 SPTLC1 FTL-1 TSC2 WIPI2 C19orf12 GTPBP2 ATG14 CP MLST8 COASY FA2H ATG2A ATP13A2 RB1CC1 MECP2 ATG3 ATG10 AKT1S1 ATG13 DEPTOR RPTOR ATG12-1 MAP1LC3A SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260710%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 ACE2 NRP1 FURIN VEGFA KDR PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260710%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway ANLN RHOA SEPTIN2 MYL2 RDX RAB35 AFAP1 KIF23 OCRL RACGAP1 MSN EZR CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260710%WP3594%HOMO SAPIENS Circadian rhythm genes EGR1 HDAC3 F7 EP300 ADIPOQ GFPT1 PTGDS GNA11 JUND AHR GSK3B PTEN UBE3A NONO SREBF1 PRF1 SIRT1 PRKAA1 PER2 CREB1 PRKAA2 MTNR1A MTNR1B GNAQ CRY2 AGRP HOMER1 NR2F6 NRIP1 PPARGC1A NCOA2 SERPINE1 PRKCG HDAC2 CHRM1 HDAC1 CDK4 MTA1 TP53 MAPK8 NTRK1 CSNK1D JUN TPTEP2-CSNK1E;CSNK1E PHLPP1 IL6 FAS TPH2 NGFR NR1H3 SLC6A4 DDX5 ADORA2A TH RELB RORC NCOR1 MAPK9 MC3R NAMPT ROCK2 UBB;UBC AHCY UBA52 TYMS NPY2R ADORA1 STAR ADCY1 DRD1 DRD3 PPARA DRD4 TPH1 ATF4 OPN4 OPN3 DDC OPRL1 SKP1 MAGED1 PRKDC DRD2 CUL1 HCRTR2 HCRTR1 ARNT TOP1 TOP2A HNRNPU CCAR2 BTRC PROK1 UTS2R METTL3 SOX14 HNF1B CLDN4 ATF5 HTR7 DHX9 NKX2-1 MTTP OGT-1 EGR3 NR1D1 SETX NMS ID4 HNRNPD ID3 FBXL3 ADA HS3ST2 ID2-1 EZH2 SUV39H2 SUV39H1 PRMT5 KCND2 SFTPC CPT1A PAX4 PROX1 KCNMA1 AVP CIPC PROKR2 ARNTL2 CST3 MAGEL2 PROK2 NPS PROKR1 NFIL3 SIK1;SIK1B RPS27A ARNT2 CAVIN3 PPP1CA MYBBP1A LGR4 RORA PPP1CB PPP1CC NAGLU CHRNB2 FBXW11 KCNH7 BHLHE41 USP2 RORB DYRK1A CARTPT SLC9A3 PSPC1 TIMELESS GHRH KMT2A CREM RAI1 ZFHX3 BTBD9 RBM4;RBM4B KDM5A GHRL HEBP1 DBP SIN3A SIX3 PRKG2 SFPQ-1 KLF10 CRY1 CLOCK THRAP3 CRH NLGN1 CRX NOS2 CIART ATOH7 NOCT NTRK3 PML TNFRSF11A KLF9 NPAS2 ARNTL NR1D2 PER1 MAPK10 LEP BHLHE40 AANAT CRTC1 PPARG MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260710%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PTBP1 SIX4 CTDSP1 PRKAA1 STRADB NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260710%WP4564%HOMO SAPIENS Neural crest cell migration during development PIK3CD RAC1 PIK3CB TIAM1 JUN PIK3CA STAT3 EPHB6 PAK5 ARF1 PIK3R3 EPHB1 EPHB3 MMP8 PIK3R6 NGEF BUB1B-PAK6;PAK6 BDNF PAK1 NGFR TRIO AKT2 PAK3 AKT3 PAK2 F2RL2 PAK4 PIK3R4 AKT1 PIK3R5 CDH11 MMP9 RHOA EPHB2 EPHB4 MMP2 FOS PIK3CG POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260710%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL18 ACE2 TMPRSS2 TNF CCL11 FURIN TLR7 IL10 TLR8 CXCL8 HMGB1-1 IL1A IL4 TLR3 GFAP IL2 IL12A IL1B IL6 MAPK1 IFNG TLR4 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260710%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis WNT3A DLL1 NOTCH1 MESP2 HES1 EPHA4 RIPPLY2 HES7 FGF8 TBX6 LFNG METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260710%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer FH PDHB PSPH PYCR1 TALDO1 PGAM1 GOT2-1 TKT PGD GLUD1;GLUD2 PKM ALDOB ACLY DLST G6PD SLC16A3 IDH3A TIGAR SHMT2 IDH2 PYCR2 SLC1A5 PAICS SDHB SUCLG2 LDHA ACO2 PGK1 RPIA PDHA1 MDH2 GPI PFKL FASN PSAT1 ENO1 SLC2A1 GLS HK3 GAPDH-1 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260710%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 FGFR2 LEF1 LRP5 CCND1 CDH1 FZD1 ITGB1 CCND2 MYC PDGFA FGF1 LAMA5 BMP4 SHH WNT5A FOXI3 NCAM1 TP63 PTCH1 GTPBP4 GJB6 EDAR GLI1 GLI2 NFKB1 EDA PDGFRA CTNNB1 RUNX2 INHBA SMO SNAI1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260710%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCD1 PIP5K1B PIP5K1A PIK3R4 INPP5D PLCG1 PIK3C2G PIK3C2A PIK3CG PTEN PIK3C2B PIK3CD PIK3CB PIK3C3 PLCE1 PIK3CA PLCB3 PLCB4 MTMR2 PLCB1 PLCH1 PLCB2 SBF2 MTMR10 MTMR12 MTMR11 PIP4P2 PIP4P1 PLCZ1 PIP4K2A PIP4K2B PIP4K2C SBF1 SACM1L MTMR1 MTMR3 MTMR8 MTMR9 OCRL MTMR4 MTMR6 MTM1 MTMR7 PLCG2 PIP5K1C PIKFYVE PLCH2 PLCD3 PLCD4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260710%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling DAGLA TRPC1 CD38 ITPR1 RYR1 RYR2 CCKBR CNR1 RYR3 GNAQ PLCB1 CCK GNAI1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260710%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence SGMS2 SMPD3 UGCG TERT KDSR RPP38 CERS4 PRKCB SGPP1 DEGS1 CERS2 PLCB1 MAPK1 MTOR SPTLC1 RB1 PRKCA CDKN1A GBA ASAH1 GLB1 E2F1 S1PR2 S1PR1 SPHK1 S1PR5 CDK4 CDK2 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260710%WP2007%HOMO SAPIENS Iron metabolism in placenta TFR2 IREB2 SLC40A1 MCOLN1 HAMP ACO1 TF STEAP3 SLC11A2 TFRC HEPHL1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5049%HOMO SAPIENS Glycolysis in senescence ALDOC TP53 LDHA PGK1 ENO1 G6PD RB1 HK1 GAPDH-1 PRKAA1 PKM 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5408%HOMO SAPIENS 15q25 copy number variation GRM1 ITPR1 RYR1 SHANK3 RYR2 TOP1 SH3GL3 RAMAC ZNF592 RNMT BNC1 AGAP2 RAF1 ADAMTSL3;ADAMTSL1 TENT4B AP3M2 BTBD1 GRM5 C15orf40 FSD2 WHAMM PDE8A SEC11A NMB HOMER2 AP3D1 WDR73 TM6SF1 AP3B2 AP3S2;AP3S1 DNM3 SPCS3 CPEB1 HTT SPCS2 SYNJ1 ALPK3 SLC28A1 ZSCAN2 NMBR SPCS1 SHANK1 SLC2A1 EGF MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260710%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation SOCS1 CD3G CD3E CD247 REL AKT1 CBLB GNA13 RASA2 MAP3K8 PIK3R2 PLCG1 NFKB1 ITK CD28 SMARCB1 GRB2 DGKA MAP4K1 TMEM222 ARIH2 ELOB CDKN1B UBASH3A RHOH DGKZ AGO3;AGO1 NDUFB10 TNFAIP3 CUL5 RNF7 ZFP36L1 PCBP2 RPRD1B MEF2D SH2B3 SH2D1A PDPK1 CD8A FIBP CD5 CARD11 MAP3K14 PIK3R1 CHUK RELA IKBKB CD3D GRAP2 VAV1 IKBKG BCL10 LCP2 MALT1 PRKCQ PTPN6 LAT ZAP70 LCK NFKBIA TRAF6 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260710%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 PNPT1 XRN1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260710%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17A IL17RC IL17RA ANO6 TLR4 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260710%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells PF4;PF4V1-1 TLR7 ICAM1 CCL13;CCL2 TGFB1 SELPLG VCAM1 SELE CD40LG TLR2 IL1B CD40 TGFB2 TGFB3 CCL5 SELP TLR4 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260710%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism ALOX5 ACSL1 FADS2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 FADS1 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PPP2R5E PPP2R5C PLK1 STAG2 SMC1A CDCA5 PDS5B PTTG1;PTTG2 PDS5A AURKB PTPA SMC1B NIPBL ESCO1 APC ESCO2 WAPL REC8 ESPL1 SGO1 SGO2 MAU2 STAG3 PPP2CB;PPP2CA SMC3 PPP2R5B PPP2R5A PPP2R1B CDK1 PPP2R1A HDAC8 PPP2R5D RAD21 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260710%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling FN1 CRTC2 KDR RPS6 TSC1 LPAR1 TNXB LAMA4 LAMC1 THBS2 COL3A1 COL5A1 COL4A2 ULK1 COL4A1 RAF1 COL5A3 COL6A2 PFKFB2 COL5A2 PFKFB3 HIF1A IRS4 ACACA EPAS1 GYS1 SLC2A1 SLC2A4 FGF2 RPTOR GSK3B PTEN PIK3CD NOS1 RPS6KB2 PIK3CB SREBF1 PIK3CA TNC PRKAA1 CREB1 PRKAA2 PIK3R1 NRAS IL6R EIF4EBP1 CAB39L MAPK1 HIF3A STRADA CAB39 MAPK3 TCL1B COL11A1 RHEB TCL1A PFKFB1 PPARGC1A PFKFB4 PPP2R1B ELAVL1 EPOR KRAS CDC37 TBC1D1 MTOR PPP2R2A;PPP2R2D RAB10 PIK3IP1 LPAR2 RPS6KB1 LPAR3 LPAR4 GNG10 PDGFD JAK1 ATF2 PDGFC CDKN1A MLST8 GNG13 LPAR5 LPAR6 RAB8A FGF7 GYS2 COL2A1 PHLPP2 RELN PDGFRA THBS1 HSP90AA1 SPP1 OSM AKT1S1 CHRM2 CHRM1 EGF FGF3 COMP FGF6 FGF9 FGFR2 EGFR IBSP TNN TNR FGF16 PGF COL4A6 EIF4E EFNA5 EFNA4 CHAD IFNB1-4 FGF20 FGF22 FGF17 EFNA1 IL2 EFNA3 FGF14 PHLPP1 EFNA2 IRS1 GNB2 STK11 FGF18 GNB4 GNB3 FGF13 FGF12 NGFR FGF11 RAB2A HSP90AB1 ITGB3 PPP2CB;PPP2CA LAMC3 MDM2-2 LAMC2 VWF PIK3R4 PPP2R5B FOXO3 PPP2R5A PIK3R5 EIF4E2 ATF6B LAMA1 LAMA3 TSC2 THBS4 THBS3 FLT1 GNG2 GNG5 GNG4 PPP2R3C GNG8 ANGPT4 HGF ANGPT2 LAMB3 INSR MET LAMB1 PPP2R3A PPP2R2C PPP2R2B CDKN1B VEGFA COL1A1 PRL PIK3C2A COL1A2 PIK3CG PIK3C2B PPP2R5E PPP2R5C BAD ITGB1 GNGT1 CSF3 IKBKB CSF3R EPO GNB1 IKBKG PRLR RAB14 CSF1R NOS3 IL7R GHR IRS2 JAK3 IL4R NGF IL3RA LAMA2 FOXO1-1 COL11A2 IL2RG IL2RA ATF4 IL2RB IFNAR2 F2R OSMR FGF1 IFNAR1 IGF1R CREB3 CREB3L3 CREB3L4 CREB3L1 EIF4E1B CREB3L2 LIPE CREB5 PDGFB VEGFB KITLG FOXA1 VEGFC VEGFD FGF19 FGFR4 COL4A4 LAMA5 VTN LAMB2 RAB11B ANGPT1 TEK FGFR1 ITGA2B PDGFA FGF4 FGF8 AKT2 AKT3 FGF10 AKT1 CASP9 PIK3R2 CSF1 PTK2 ITGA10 ITGA11 GRB2 JAK2 ITGAM ITGB5 ITGB4 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 HRAS NOS2 ITGA4 PDPK1 PDGFRB ITGA3 ITGA2 ITGAD ITGA8 ITGA7 INS;INS-IGF2 ITGA6 ITGA5 FLT4 SOS1 ITGA9 HSP90B1 IGF1 MAP2K2;MAP2K1 FGF21 KIT EIF4B EPHA2 PPP2R1A DDIT4 SLC2A2 PPP2R5D FGFR3 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260710%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 ACE AGTR1 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260710%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG2;HBG1 HBZ LDB1 HBD;HBB TAL1 LMO2 GATA1 HBA2;HBA1 APOPTOSIS%WIKIPATHWAYS_20260710%WP254%HOMO SAPIENS Apoptosis IRF7 TNFRSF25 TP53 TNFRSF21 BCL2L11 TNF BAK1 BID MCL1 JUN CDKN2A CFLAR BCL2 FAS BAX MYC IRF4 BCL2L1 IRF2 IGF1R MDM2-2 AKT1 APAF1 TRADD CASP9 TRAF1 CYCS-1 CASP7 TNFRSF1B CASP8 TRAF3 CASP3 PMAIP1 RIPK1 NFKBIE FADD BIRC3 BIRC2 CASP5;CASP4 NFKB1 TP73 CASP2 BBC3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BCL2L2 PRF1 BOK IRF5 MAP3K1 BAD PIK3R1 CHUK RELA IRF6 IGF1 IKBKB IRF1 IKBKG BNIP3L MAPK10 TP63 GZMH;GZMB-1 HRK IGF2 FASLG CASP6 CASP10 CASP1 TNFSF10 DFFB HELLS DFFA SCAF11 XIAP MAP2K4 CRADD DIABLO-1 IRF3 NFKBIB TRAF2 BIRC5 NFKBIA TNFRSF1A LTA EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260710%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2C POLR2E POLR2F POLR2G POLR2H POLR2I GTF2F2 POLR2J;POLR2J2;POLR2J3 POLR3B POLR3D TAF12 TAF7 POLR3H TAF6 TAF5 POLR3K POLR3E TAF13 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR1E GTF2H1 GTF2H3 TBP GTF2H4 CDK7 POLR1A ERCC3 POLR1B POLR1D GTF2A2 GTF2B ILK ERCC2 TAF9 GTF2E1 GTF2E2 MNAT1 POLR2A POLR2B 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome POLR2E POLR2F SOCS3 SOCS1 BCL2L11 POLR2H IL1RL2 ZC3H8 ZC3H6 CHCHD5 IL2 ACOXL IL1RN PSD4 ARL14 IL6 CKAP2L IL36A POLR1F IL36B POLR1G POLR1H FBLN7 TMEM87B SLC20A1 TULP1 TTL POLR2L IL36G IL1R1 POLR1E ARF6 IL1F10 CSF1 LGALS3 ANAPC1 IL1B PTK2 GRB2 IL23A CXCL13 RAC1 GATA3 IL37 GAS6 CSF2 MAPK1 MERTK IL1RAP IL1A IL36RN POLR1A POLR1B POLR1C POLR1D PLCG2 STAT1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome TRPM1 FANCD2 FAN1 GRM6 FYN CREBBP MTMR10 KAT2B CHRNA7;CHRFAM7A SERPINH1 GPR75 CCL5 KLF13 OTUD7A PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260710%WP4022%HOMO SAPIENS Pyrimidine metabolism POLR2C POLR2E POLR2G POLR2H POLR2I POLR2J;POLR2J2;POLR2J3 POLR3B POLR3D POLR3H POLR3K POLR1F POLR1H POLR2L POLE TK2 ENPP3 ENTPD1 ENTPD3 RRM2-1 CAD NME3 POLR1E CTPS2 CTPS1 DCK NME1 DCTD POLD3 CDA NME6 POLD4 DPYS NME7 CMPK1 TYMP CMPK2 POLD1 UPRT POLD2 POLE4 DCTPP1 UPP1 DTYMK TK1 NME4-1 NT5C UPB1 POLR2D POLE2 NT5M DUT UCK1 POLE3 DPYD POLR3GL UMPS DHODH UCKL1 POLR3A POLR3C POLR3F POLR3G RRM1 NME2 PNPT1 RRM2B POLR3E PRIM2 PRIM1 TYMS POLA1 POLA2 ENPP1 POLR1A POLR1B POLR1C POLR1D POLR2A POLR2B CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260710%WP536%HOMO SAPIENS Calcium regulation in cardiac cells ORAI1 ADCY6 CHRM3 ADCY5 CACNA1S ATP1B2 GJA5 ADRA1B ADRA1A PRKD1 RGS16 CAMK2A GRK6 GNA11 CALM1 SFN ITPR1 YWHAE YWHAB CAMK2B YWHAG GNAO1 ADRA1D YWHAH ADRB1 CACNA1C ADRB2 GNAQ CALM3;CALM1 RGS14 PRKCD CALM2 GNAI3 GNAI1 PRKCQ GNAI2 CAMK4 CAMK1 GNG13 KCNJ5 PRKCG PRKCH PRKCZ CHRM2 CHRM1 FKBP1A GNB2 GNB4 GNB3 GNB5 GNG2 GNG5 GNG4 GNG8 RGS4 RGS5 RGS2 RGS3 ADCY4 GJA3 ADCY2 RGS1 ARRB1 GJA4 ARRB2 CAMK2D GJA9 PRKACB-1 GJA8 RGS9 RGS6 PRKCB RGS7 RYR1 ATP1B1 RYR2 STIM2 ADRB3 GNAZ RYR3 CACNA1B PLCB3 CACNA1A ADCY9 ITPR2 ITPR3 CACNA1E GJC1 CALR-1 GJC2 GNAS-1 GRK5 GRK4 GNGT1 PKIB GJB2 PRKACA-1 GJB4 GJB3 PRKCE PKIA GNB1 GJB5 PKIG ATP2A3 PRKAR1B YWHAQ ANXA6 GJD2 PRKAR1A CASQ2 CASQ1 RGS18 RGS17 GJB6 ATP2A2 RGS19 SLC8A1 ATP1A4 GJA1 RGS20 CAMK2G PRKCA KCNJ3 CHRM4 KCNB1 ATP1B3-1 CHRM5 ATP2B3 YWHAZ ATP2B2 GJB1 FXYD2;FXYD6-FXYD2 PRKAR2B ATP2B1 PRKAR2A SLC8A3 RGS11 CACNB1 RGS10 CACNB3 ADCY3 ADCY1 ADCY8 ADCY7 CACNA1D COPPER HOMEOSTASIS%WIKIPATHWAYS_20260710%WP3286%HOMO SAPIENS Copper homeostasis STEAP1 TP53 FOXO1-1 STEAP2 ATP7B SLC31A1 SLC11A2 ADAM9 CCND1 ATP7A JUN PIK3CA ADAM17 APC SP1 MDM2-2 AKT1 FOXO3 ADAM10 CASP3 SOD3 SOD1 MTF2 STEAP4 COX17 XIAP MT2A COX11 PRNP STEAP3 SLC31A2 BACE1 COMMD1 APP MT3 ATOX1 CCS GSK3B SCO1 MAPT PTEN MTF1 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260710%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 UBE2V1 TIFA AJUBA NFKB1 UBE2N PRKCZ SQSTM1 IL1A TRAF6 MIRNA BIOGENESIS%WIKIPATHWAYS_20260710%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA TARBP2 RAN DICER1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260710%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma SUZ12 H3-3A KDM2B DUSP6 RNF2 PCGF1 BCOR EED H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AZ2;H2AZ1 EZH2 H2AJ H2AB2;H2AB3;H2AB1 MACROH2A2 MACROH2A1 BCL6 MAPK1 MAPK3 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260710%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR PIK3CB HRAS CCND1 ERBB2 PIK3CA PIK3R3 INS;INS-IGF2 PIK3R1 IRS1 PIK3R6 NRAS ESR1 CCNE1 RAF1 IGF1R MAPK1 AKT2 AKT3 MAPK3 PIK3R4 AKT1 PIK3R5 KRAS MTOR PIK3R2 CDKN1A CYP19A1 CDKN1B PIK3C2G PIK3C2A PIK3CG CDK6 RPTOR CDK4 CDK2 PIK3C2B CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260710%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 XDH CYP2A13;CYP2A6;CYP2A7-1 LUNG FIBROSIS%WIKIPATHWAYS_20260710%WP3624%HOMO SAPIENS Lung fibrosis SMAD7 TNF TERT CMA1 FAM13A ELMOD2 ATP11A RTEL1 PARN IL6 SFTPC DPP9 STN1 MUC5B PLAU PTX3 PDGFA FGF1 GREM1 HMOX1 CCL11 CCL4L2;CCL4L1;CCL4 CCL13;CCL2 CXCL8 CCN2 IL12B HGF PDGFB MMP9 IL1B MECP2 IL13 CXCL2;CXCL3;CXCL1-1 NFE2L2 FGF2 CALCA EDN1 CCL3L1;CCL3L3;CCL3;CCL18 TGFB1 IL4 IL5 TIMP1 CSF3 IGF1 CCL5 CSF2 CEBPB TGFA CCR3 CCR2 DSP FGF7 CYSLTR2 BMP7 MT2A MMP2 SPP1 SKIL EGF SERPINA1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260710%WP408%HOMO SAPIENS Oxidative stress response CYP1A1 CAT NOX3 MAPK14 NOX4 CYBB NFIX TXN2 GPX1 NQO1 TXNRD2 SP1 TXNRD1 GCLC MAOA SOD2 NOX5 NOX1 UGT1A1;UGT1A6 MAPK10 HMOX1 XDH GSTT2B;GSTT2 SOD3 SOD1 MGST1 JUNB NFKB1 NFE2L2 FOS GSR TNF ALPHA SIGNALING%WIKIPATHWAYS_20260710%WP231%HOMO SAPIENS TNF alpha signaling CYBA TANK MAPK8 TNF MAP2K7 BID CREBBP MAP2K6 JUN CFLAR BAX BCL2L1 MAP3K7 RAF1 PPP2CB;PPP2CA REL KSR1 NOX1 OTUD7B AKT1 PYGL APAF1 RIPK3 TRADD RFK CASP9 PSMD2 KSR2 TRAF1 PTPRCAP CASP7 TNFRSF1B NSMAF CASP8 NOXO1 CASP3 TXN RIPK1 RFFL NFKBIE MAP3K8 SKP1 FADD BIRC3 FBXW11 BIRC2 NFKB1 CUL1 NFKB2 GRB2 MAP4K2 TAB3 TAB2 TNFAIP3 RAC1 MAP3K3 PLK1 HRAS MAPK9 MAP3K1 BAD MAP3K14 SOS1 NRAS CHUK IKBKB MAPK1 IKBKG MAPK3 KRAS CDC37 TAB1 TBK1 CSNK2A1;CSNK2A3 MAP3K5 MAP2K3 MAP2K4 DIABLO-1 SMPD2 HSP90AA1 PRKCZ NFKBIB BTRC GLUL TRAF2 NFKBIA TNFRSF1A MADD TRAP1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EXOC1 EGFR CFL1 PCNA SUZ12 IFNB1-4 MCL1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRMT5 SDC2 BCL2 CCNE1 RAF1 NGFR RFC5 RFC3 RFC4 RFC2 ARF6 WDR48 HOXA9 OMG SYN1 POLRMT MYT1 EVL ATAD5-1 RTN4R RAD51 RNF135 CCNE2 ADAP2 INPP5A USP1 RBBP7 E2F6 RAB11FIP4 EXOC7 TEFM UTP6 LIMK1 SUPT5H COPRS EVI2A CRLF3 EVI2B CRY1 MAP3K2 EZH1 RAD9A METAP2 ATR EED MAP3K1 SOS1 ROCK2 MAPK1 MAPK3 JARID2 PER1 MAVS DNMT1 RAB11A NF1 HOXA1 H4C1 H4C6 H4-16 RHOA CCNA2-1 DDX58 EXOC8 TUBB4A;TUBB;TUBB8B;TUBB8 EXOC4 EXOC3 EXOC6 EIF3A EXOC5 EGF NGF EXOC2 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma TP53 HNF1A MAPK8 CCND1 PTPN11 JUN MAPK14 IL6 MYC COL4A2 BCL2L1 AKT1 HIF1A CASP9 CASP7 SMAD2;SMAD3 RRM2-1 CASP3 BIRC3 CXCR1 CXCL8 SMAD4 NFKB1 PTGS2-2 GRB2 VEGFA RAC1 MMP1 BRCA1 UCHL1 MYOF NOS2 CD44 FRZB LEF1 VAV2 TGFB1 STAT3 SOS1 IL6R MAPK3 PODXL E2F2 TGFBR1-1 JAK1 CDKN1A FASLG CTTN BIRC5 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260710%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer SMAD7 TNFRSF21 SOCS3 HSPD1 CTNNA1 TNF PTK2B BCL3 F2R NQO1 SQSTM1 AKT1 TRAF1 CASP7 NRG1 PTK2 NFKB1 CUL1 JUND HSPA5 CDKN1B ERN1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CUL5 RNF7 AXIN1 VAV3 SERBP1-1 YBX3 IER3 RIPK2 ANXA5 CARD14 BEX3 NET1 HSPB1 APOE MAPK1 GCLC PAK2 PKN1 ETS1 ABL1 RPS6KB1 VIM CDKN1A HELLS IL7R THBS1 ERBB3 APP BIRC5 HDAC1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260710%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development ATF6 DNM1L CSNK2A2 SEMA3A SCN2A CSNK2A1;CSNK2A3 EIF2A ATF4 SPTBN4 SNAP25 BRSK1 BRSK2 ANK2 PRICKLE1 ANK3 PRRT2 L1CAM CSNK2B KCNQ2 EIF2AK3 SCN5A SPTAN1 DDIT3 MAPT CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias SC5D LBR DHCR7 DHCR24 EBP NSDHL CYP51A1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260710%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ MAP3K14 NFKB1 CHUK IKBKB MAP2K6 RAF1 NFKBIA RRAS MAPK1 MAP3K1 TRAF6 IKBKG NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260710%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S2 EIF2S3;EIF2S3B EIF1 EIF5 EIF1AY;EIF1AX EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF2S1 EIF3D EIF3A EIF3B EIF3C;EIF3CL HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260710%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAPK8 EIF4E BST2 MAP2K7 MAPK9 IFITM3;IFITM2;IFITM1 MAP2K6 JUN MAP3K1 MAPK14 MAPK12 MAPK13 MAPK11 BCL2 MAP2K2;MAP2K1 MAP3K4 RAF1 MAPK1 MAP3K9 MAPK3 MAPK10 RPS6KA3 RPS6KA2 ATF2 MAP3K10 MAP3K11 JUNB MAP2K3 MAP2K4 FOS DDIT3 RPS6KA1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260710%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis PTGS2-2 PTGS1 KCNQ2 FAAH TRPA1 KCNQ3 HTR1A TRPV1 CACNA1H CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260710%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling MAPK8 RAPGEF3 NR4A1 MAPK14 JUP IL2 CYP11B1;CYP11B2 GNB2 TRIM28 BCL2 GNB3 TCF4 GNB5 RAF1 AKT1 IL18 ACACA CASP9 SULT2A1-4 CASP3 RAP1B TFAP2A CXCL8 CAMK2A GRK6 BRAF PLCG1 PTK2 NFKB1 GNA11 CYP11A1 FOSL1 JUND FOSL2 FOSB ERN1 GSK3B CRH ARRB1 ARRB2 MAPK9 PARP1 PRKCB TGFB1 ECE1 POMC CREB1 GNAZ PRKAA2 GNAO1 GNAQ PRKCD GNAS-1 RELA MAP2K2;MAP2K1 MAPK1 SP1 GNB1 MAPK3 GNAI1 CACNA1H CRHBP PRKCQ GNAI2 KRT16;KRT14 NCOA2 KRT1 IVL CRHR1 CRHR2 GRK3 TBX19 NR4A2 GJA1 PRKCA NOS3 CYP21A2 ELK1 RHOA JUNB MAP3K5 PRKCI HSP90AA1 HSD3B1;HSD3B2 STAR PLCG2 CTNNB1 FOS NFKBIA TLR4 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260710%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM4 GRM7 GRM6 GRM1 GRM8 GABBR1 CASR GPRC5B GPRC5A GPRC5D GPRC5C GABBR2 GRM3 GRM2 GRM5 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260710%WP5572%HOMO SAPIENS Nucleosome remodeling complex RBBP4 PCNA CHEK2 H4C1 H4C6 H4-16 NASP-1 XRCC6 DAXX SUPT16H PRKDC XRCC5 NAP1L1 SSRP1 HAT1 IPO4 CHAF1B CHAF1A ASF1A SMIM40 ASF1B MCM2 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260710%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism SDR16C5 RDH12 RARA AWAT2 RARB RDH10 LRAT RXRA NPC1L1 BCO2 BCO1 RXRG LPL DGAT1 DHRS3 RPE65 RBP7 RBP2 CYP26B1 RBP1 CD36 RDH5 RBP4 MAPK1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 ALDH1A1 CYP2E1 ALDH1A3 ALDH1A2 RARG ADH4 ADH1C;ADH1B;ADH1A SCARB1 ABCG8 RETSAT ABCG5 CRABP2 RDH8 CRABP1 RLBP1 CYP26A1 RXRB SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260710%WP2267%HOMO SAPIENS Synaptic vesicle pathway CLTC SLC1A3 PARK7 RIMS1 SLC18A1 SLC18A2 AP2M1 SLC18A3 NSF UNC13C AP2A1 SLC38A1 SYP AP2A2 SYN3 SYN2 SLC25A4 VAMP2 NAPA SLC22A3 ATP1A2 CPLX2 CLN8 CPLX1 SLC6A4 CPLX3 AP2S1 SLC17A6 UNC13B SLC17A7 STX3 SLC17A8 STX2 SLC32A1 SYT1 SYN1 DNM3 STXBP1 STX1A DNM1L AP2B1 CLTCL1 CLTA SNAP25 DNM1 CACNA1B CACNA1A RAB3A DNM2 UNC13A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260710%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling TP53 FOXO1-1 FGFR2 EGFR FZD6 NTRK1 CCND1 BCL9 JUN KDR JUP TEK TSC1 CSNK1A1 FGFR1 TELO2 IL6 MYC RAF1 IGF1R NGFR AKT2 AKT3 MDM2-2 REL KSR1 AKT1 TSC2 NFKBIE WNT1 FLT1 SALL4 TTI1 GAREM2 PYGO1 RETN RUNX1T1 ZBTB16 BRAF INSR PTK2 NFKB1 MET GRB2 JAK2 FGFR4 PIK3CG DEPTOR GSK3B RPTOR PTEN PIK3CD RARA PIK3CB HRAS SOS2 LEF1 PDGFRB LRP5 PML PIK3CA STAT3 FLT4 SOS1 ULK2 APC IL6R CHUK SRC NTRK2 RELA MAP2K2;MAP2K1 IKBKB PPARD MAPK1 LRP6 IKBKG MAPK3 RHEB KRAS MTOR KIT SHC1-1 CSF1R FLT3 CDKN1A MLST8 EPHA2 ELK1 PDGFRA FGFR3 AKT1S1 CTNNB1 FOS NFKBIA AXIN2 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260710%WP3930%HOMO SAPIENS EDA signaling in hair follicle development LTB BMP1 PTCH1 EDAR WNT3 GLI1 EDARADD DKK4 SOSTDC1 RELB EDA DKK1 SHH TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260710%WP3945%HOMO SAPIENS TYROBP causal network in microglia IL10RA SLC7A7 STAT5A CD4 MAF C3-1 SLC1A5 IL18 TNFRSF1B CREB3L2 C1QC ADAP2 CD84 LGALS9C;LGALS9;LGALS9B NRROS ITGAM FKBP15 ABCC4 PLEK ITGB2 LOXL3 TCIRG1 DPYD PYCARD LYL1 CD37 ITGAX RNASE6 RPS6KA1 APBB1IP BIN2 ELF4 SFT2D2 TMEM106A RBM47 IGSF6 SH2B3 RGS1 KCNE3 CAPG SAMSN1 ZFP36L2 HLX CYTL1 NCKAP1L PPP1R18;LOC107987457 LHFPL2 GAPT GAL3ST4 GPX1 TYROBP IL13RA1 TGFBR1-1 RUNX3 NCF2 NPC2 HCLS1 SPP1 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260710%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG1 PRKAG2 PRKAG3 PRKACB-1 PRKAB2 PRKAB1 ACSS2 ACSBG1 PRKAA1 PRKAA2 PLIN1 ACLY PRKACA-1 AKT2 AKT3 AKT1 BCKDHA PRKAR1B ACACA PRKAR1A PDHA1 LIPE ABHD5 PNPLA2 PRKAR2B PRKAR2A FASN CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway SQLE HMGCR MVD DHCR7 IDI1 MVK MSMO1 HMGCS1-1 NSDHL PMVK SC5D FDFT1 FDPS LSS CYP51A1 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260710%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP1A2 EPHX3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX15 ALOX12B ALOXE3 PTGS2-2 PTGS1 GPX4 CYP2C9;CYP2C19 DOPAMINE METABOLISM%WIKIPATHWAYS_20260710%WP2436%HOMO SAPIENS Dopamine metabolism COMT TH PRKACB-1 NQO1 PRKACA-1 MAOB SOD1 DDC MAOA PPP2CB;PPP2CA TYR FELBAMATE METABOLISM%WIKIPATHWAYS_20260710%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260710%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming DNMT1 CREBBP IFITM3;IFITM2;IFITM1 EP300 DNMT3A PIP4K2A EZH2 FTO IRS1 ANKRD13C GGT6 CADM1 YTHDF3 TET2 NOL9 HDAC2 HDAC1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260710%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD8B;CD8B2 NFATC3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD8A PTPN11 JUN STAT3 NFATC2 NFATC4 CD3G CD3E NFKB1 ZAP70 NFATC1 LCK NFAT5 CD3D CD274 PDCD1LG2 BATF IFNG PDCD1 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260710%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction MYL1 CD38 GDI1 PPP1CB RYR1 RHOA ADRB2 GNAQ IL13 ITPR3 ROCK1 ROCK2 PLCB1 CALM1 PPP1R14A MYLK ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260710%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT1 MTOR AKT2 AKT3 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260710%WP3871%HOMO SAPIENS Valproic acid pathway ACSM1 CYP2B6 IVD ACADSB HADHB-1 HSD17B10 ABAT EHHADH-1 CYP2A13;CYP2A6;CYP2A7-1 HADHA HDAC1 CYP2C9;CYP2C19 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260710%WP545%HOMO SAPIENS Complement activation C8G C8B MASP2 MASP1 C1QC CFD C6 C8A C7 C9 CD55 CFB C1QB C3-1 C1S CFP C1R C2 C5 LOC110384692;C4A;C4B_2;C4B TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260710%WP691%HOMO SAPIENS Tamoxifen metabolism FMO1 CYP1A2 CYP1A1 CYP2E1 FMO3 SULT2A1-4 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 CYP2A13;CYP2A6;CYP2A7-1 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP2C9;CYP2C19 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260710%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways TSC1 GABRB3 GABRB2 CYP46A1 GABRB1 RAF1 GABRG3;GABRG2 ABCA1 MAP3K10 GABRE GABRQ GABRA2 GABRP GABRA1 DEPTOR SLC12A5 RPTOR GABRA6 PTEN GABRA5 PRKAG1 GABRA4 PIK3CD PRKAG2 PIK3CB GRM1 ITPR1 PRKAG3 PRKAB2 RPS6KA5 PRKAB1 PIK3CA PRKAA1 CREB1 PRKAA2 PIK3R3 PIK3R1 RAB3A EIF4EBP1 NTRK2 BDNF APOE MAPK1 OPA1 MAPK3 RHEB PPARGC1A MTOR RPS6KB1 MLST8 ELK1 MAP2K4 AKT1S1 HDAC2 EGF HDAC1 CYP51A1 BNIP3 EGFR MAPK8 BCL2L11 EIF4E MAP2K7 BID HMGCS1-1 HMGCS2 SLC12A2 IL6 PIK3R6 BCL2 RICTOR BAX BCL2L1 NR1H2 AKT2 AKT3 SREBF2 AKT1 PIK3R4 PIK3R5 DHCR7 CASP7 ABCG1 CASP8 CASP3 TSC2 PIK3R2 HTT IL1B NFKB1 GABRD PIK3C2G PIK3C2A SIN3A PIK3CG PIK3C2B GABRA3 HMGCR HRAS MAPK9 HAP1 PRR5L BAD MAP2K2;MAP2K1 IKBKB SP1 MAPK10 KIF5A ABCG4 NEUROD1 AHI1 CKB REST RAB3GAP1 MBP GABRG1 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260710%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders H4C1 YES1 H4C6 SRRT H4-16 SOX11 SOX12 POU3F1 SOX2 POU3F2 UTF1 SOX15 ZSCAN10 WWTR1 SOX4 FGF4 TEAD2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260710%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome GRIA1 GRIA2 HRAS GRM1 ITPR1 SYNGAP1 SHANK3 ITGB1 ARHGEF7 HOMER1 PAK1 MAP3K7 SPTAN1 GRIN2B GRIN1 CDC42 GRM5 DLG4 RAP1A CAMK2A CTTN CTNND2 ARHGAP44 SHARPIN DLGAP1 ACTB-1 LZTS3 DBNL BAIAP2 ABI1 ADGRL1 TAB2 HCN1 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260710%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 TNF IFNB1-4 GOT2-1 AADAT HAAO KYNU AFMID IL1B KMO IL6 KYAT3 KYAT1 IDO2 IDO1 AHR DDC IFNG OXYTOCIN SIGNALING%WIKIPATHWAYS_20260710%WP2889%HOMO SAPIENS Oxytocin signaling PLCD1 GNAQ OXTR CD38 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260710%WP1533%HOMO SAPIENS Vitamin B12 metabolism MPO MCEE MMUT F2 CUBN SAA2-SAA4;SAA4 F7 LRP2 TNF MMAB APOA1 TCN1 ICAM1 PLG PLAT IL6 SHMT2 SOD2 HBD;HBB SOD3 CCL13;CCL2 ABCA1 SOD1 IL1B INSR NFKB1 NFKB2 CTH SCARB1 LDLR INS;INS-IGF2 RELA APOE CCL5 APOB ALB MTRR SERPINE1 MTR-1 SAA2;SAA1 HBA2;HBA1 FGB MTHFR FGA MAT1A FGG CBLIF TCN2 IFNG CBS;CBSL CRP SERPINA3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260710%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects TP53 FOXO1-1 KLB KDM1A TRH TTF2 TTF1 NHSL1 IYD MAPK14 DUOXA2 RPS6 TSHB TSC1 FGFR1 SECISBP2L DIO1 DIO3 SIRT6 LOC100509620;LOC112267859;AQP7 PAX8 ZNF516 MGLL KDM3B RAF1 SLC5A5 DUOX2 ITGB3 SLC16A10 SHH AKT3 PFKFB2 MAFA MDM2-2 TSHR TG SLC26A4 CASP9 FRS2 CREB3 RPS6KA6 TSC2 SLC16A2 WNT4 THRB THRA GRB2 SLCO1C1 MAP4K5 GSK3B RPTOR PRKG2 ACTL6B NPPB ITGAV HRAS NOTCH1 RXRA PIK3CA ADRB3 POMC TPO PLIN1 BAD MAPKAPK3 SOS1 ITPR2 MC4R TBC1D4 NPY SRC AGRP PRDM16 UCP1 MAP2K2;MAP2K1 PRKACA-1 MAPK1 RHEB PPARGC1A FGF21 NPR1 MTOR RPS6KB1 ATF2 MLST8 PNPLA2 AKT1S1 ADCY3 CTNNB1 ADCY8 PPARG METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260710%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PHGDH PSPH PYCR1 CD36 GLUD1;GLUD2 FGFR1 LPAR1 SERPINH1 SLC1A5 PLOD1 LDHA GCK LOXL2 ADAMTS2 UGP2 PGM1 BMP1 P3H4 P3H3 UGDH SLC16A1 P4HA1 P4HA2 P4HA3 ALDH18A1 GPI RHOA PLCG1 PSAT1 SLC2A1 GLS FGFR4 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260710%WP4262%HOMO SAPIENS Breast cancer pathway HES1 HES5 CCND1 FZD1 JAG2 CSNK1A1 FZD7 DLL1 FZD8 DLL3 SFRP4 FGF1 RAF1 IGF1R GADD45A SKP1 FRAT2 SHC2 PGR NOTCH3 ESR2 DDB2 NOTCH4 CETN3 HEY1 APC2 DLL4 HEYL FGF19 FGF2 GSK3B PTEN PIK3CD GADD45B BRCA1 RPS6KB2 GADD45G POLK PARP1 ATR PIK3CA PIK3R3 PIK3R1 NRAS NCOA1 CSNK2B MAPK1 LRP6 MAPK3 E2F2 E2F3 KRAS NCOA3 MTOR CSNK2A2 RPS6KB1 RB1 CSNK2A1;CSNK2A3 CDKN1A FGF7 FGF23 E2F1 FOS EGF FGF3 CDK6 CDK4 FGF5 FGF6 TP53 FGF9 FZD6 EGFR FZD9 FGF16 BAK1 FZD10 SHC4 FGF20 JUN FGF22 FGF17 FGFR1 FGF18 ARAF BAX MYC FGF4 FGF8 AKT2 WNT5B AKT3 WNT5A TCF7 FGF10 AKT1 WNT6 DVL1 DVL2 SHC3 DVL3 MRE11 PIK3R2 WNT1 WNT2 BRCA2 WNT3 WNT4 WNT10B WNT10A RAD50 RAD51 WNT3A BRAF NBN TNFSF11 NFKB2 GRB2 ATM WNT2B AXIN1 WNT16 NOTCH1 HRAS SOS2 LEF1 LRP5 FZD5 WNT11 ERBB2 FZD2 TCF7L2 TCF7L1 WNT7B FLT4 SOS1 WNT7A APC ESR1 IGF1 MAP2K2;MAP2K1 SP1 FGF21 KIT SHC1-1 NOTCH2 FZD3 HEY2 CTNNB1 AXIN2 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260710%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways OAT PEPD PRODH;LOC102724788 PYCR1 ALDH4A1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260710%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS TNF CNTF OLIG2 ASCL1 IGF1 SOX10 SOX6 BMP4 SHH BMP2 SOX9 SOX5 OMG MBP MYT1 PDGFB GLI2 IL1B CNP SOX8 CXCL2;CXCL3;CXCL1-1 NKX2-2 NKX2-6 MOG MAG PLP1 FGF2 OLIG1 LIF ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP1541%HOMO SAPIENS Energy metabolism PRKAG1 ESRRA PPP3CA MEF2A FOXO1-1 PRKAG2 PPP3CB MED1 PRMT1 MEF2D TFB2M RXRA PPRC1 PRKAG3 MEF2B;BORCS8-MEF2B SIRT3 PRKAB2 PRKAB1 PPARA EP300 PRKAA1 MAPK14 SIRT1 PRKAA2 CREB1 NCOA1 PPARD PPP3CC PPP3R1 PPARGC1B FOXO3 PPARGC1A MYBBP1A CAMK4 CAMK2G ATF2 UCP2 GABPA MEF2C NRF1 HDAC1 TFB1M GSK3B TFAM-1 UCP3 PPARG STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260710%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 HSD3B1;HSD3B2 CYP17A1 STAR HSD17B1 CYP19A1 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260710%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2A SRF MEF2D CCND2 MEF2B;BORCS8-MEF2B CAMK2D MYOCD NKX2-5 MEF2C KLF4 ELK1 IL1 SIGNALING%WIKIPATHWAYS_20260710%WP195%HOMO SAPIENS IL1 signaling UBE2V1 MAPK8 MAP2K7 MAP2K6 PTPN11 JUN MAPK14 MAP3K7 SQSTM1 REL AKT1 IL1R1 PIK3R2 IL1B PLCG1 NFKB1 UBE2N IRAK2 TOLLIP TAB3 TAB2 MAP3K2 MAP3K3 IRAK3 IRAK4 PELI1 MAPK9 HSPB2 ECSIT MAP3K1 IRAK1 MAP3K14 PELI2 PIK3R1 MAPKAPK2 CHUK RELA MAP2K2;MAP2K1 IKBKB MAPK1 IKBKG MAPK3 IL1RAP TAB1 MYD88 ATF2 IL1A MAP2K3 MAP2K4 PRKCZ NFKBIB NFKBIA TRAF6 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260710%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides A3GALT2 SGMS2 UGCG SPTLC1 DGAT1 KDSR CERS4 CERS3 CERS5 CERS2 CERS6 B4GALT1 CERK SGMS1 DES UGT8 A4GALT CERS1 B3GNT5 ASAH1 SPHK1 B4GALNT1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260710%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KYNU AFMID KMO NMNAT1 TDO2 NADSYN1 QPRT HAAO CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260710%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 CHUK RELA NFKBIE IKBKB NFKBIA REL IKBKG SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260710%WP1422%HOMO SAPIENS Sphingolipid pathway SGMS2 GAL3ST1 UGCG KDSR CERS4 CERS3 CERS5 CERS2 CERS6 CERK SGMS1 UGT8 ASAH2 GBA2 SGPL1 SPTLC3 CERT1 SGPP2 ACER1 PPP2CB;PPP2CA SERINC1 B4GALT6 PLPP1 PPP1CA SPTLC1 GBA ASAH1 SPHK2 SPHK1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260710%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis SPARC SNAI2 GPC6 FN1 BCAR1 PBX3 YAP1-1 THBS2 COL3A1 COL5A1 TEAD1 TEAD2 EDNRA TEAD3 TEAD4 COL1A1 ALSTROM SYNDROME%WIKIPATHWAYS_20260710%WP5202%HOMO SAPIENS Alstrom syndrome IFT172 ACTN4 IFT81 TFDP2 IFT74 GPR161 CEP19 BLOC1S4 VCPIP1 BLOC1S6 PTCH1 BLOC1S1 VCP-1 STX5 HSPB11 SNAPIN PIFO RFX2 DTNBP1 DNM3 RFX3 RFX1 TUBG1 RABL2A;RABL2B ARMCX5-GPRASP2;GPRASP2 E2F4-1 NSFL1C CEP192 RILPL1 MYO5B ALMS1 IFT27 SMO ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260710%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria NDUFS4 NDUFS2 NDUFS1 SLC25A14 SLC25A6 NDUFB9 NDUFB8 NDUFB7 COX7A2L-1 NDUFB6 NDUFB5 COX15 NDUFB4 NDUFB3 NDUFB2 ATP5MC2 NDUFB1 ATP5MC3 SLC25A5 COX7A2 ATP5MC1 SLC25A27 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 COX6A1 NDUFV2 ATP5MG SLC25A4 ATP5ME DMAC2L ATP5PF NDUFA8 SURF1 NDUFA7 NDUFA6 ATP5PD ATP5PB NDUFA3 COX6B1 ATP5F1C ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 COX7B NDUFB10 COX4I1 UCP3 UQCRFS1 NDUFS8 UQCRC1 COX7C NDUFS3 UQCRC2 UQCRB UQCR11 UQCR10 COX8A NDUFV1 NDUFA9 NDUFA4 UQCRQ UCP1 SDHA COX5B COX5A SDHB NDUFA5 COX6C UCP2 NDUFA13 COX17 NDUFA11 NDUFA12 COX11 NDUFA10 COX6A2 ATP5IF1 SDHC NDUFC1 SDHD NDUFS7 SCO1 NDUFS6 G PROTEIN SIGNALING%WIKIPATHWAYS_20260710%WP35%HOMO SAPIENS G protein signaling ADCY6 ADCY5 PDE1A GNB2 GNB3 GNB5 PRKD1 PDE8A GNA13 GNA12 ARHGEF1 AKAP9-1 AKAP12 GNG5 AKAP13 GNG4 AKAP10 AKAP11 GNG8 PDE4B PDE4A PDE8B PDE4C PDE1C PDE1B GNA11 AKAP8 AKAP7 CALM1 AKAP6 AKAP5 AKAP4 AKAP3 SLC9A1 AKAP1 GNA14 PDE4D-1 PDE7B PDE7A PPP3CA HRAS ADCY4 ADCY2 ITPR1 PRKACB-1 GNA15 PRKCB GNAZ PLCB3 GNAO1 ADCY9 GNAQ NRAS PRKCD GNAS-1 GNGT1 GNAI3 PRKACA-1 PPP3CC PRKCE GNB1 GNAI1 PRKCQ GNAI2 PRKAR1B PRKD3 KRAS PRKAR1A GNG10 PRKCA KCNJ3 GNG13 RHOA PRKAR2B PRKAR2A PRKCG PRKCI PRKCH GNAL PRKCZ ADCY3 ADCY1 RRAS ADCY8 ADCY7 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5292%HOMO SAPIENS Glycosphingolipid metabolism A3GALT2 B4GALT4 B4GALT5 GAL3ST1 UGCG ARSA B4GALT3 GBA UGT8 GALC A4GALT NEU3 NEU4 B3GALT2 B3GNT5 GBA2 GLA B3GALT1 ST3GAL5 B4GALT6 B4GALNT1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260710%WP1995%HOMO SAPIENS Effects of nitric oxide NOS1 MB NOS2 XDH AOX1 HBD;HBB NOS3 HBA2;HBA1 FERROPTOSIS%WIKIPATHWAYS_20260710%WP4313%HOMO SAPIENS Ferroptosis TP53 ACSL6 ACSL5 TF SLC11A2 TFRC MAP1LC3B2;MAP1LC3B-1 NOX4 IREB2 SLC40A1 SAT1 FDFT1 CYBB SLC38A1 ACSL1 ACSL4 ACSL3 TXNRD1 SLC1A5 NOX1 ALOX15 HMOX1 CTH STEAP3 MAP1LC3A PCBP2 HMGCR CISD1 SAT2 BACH1 VDAC2-1 MAP1LC3C AIFM2 FTH1 SLC39A8 NCOA4 SLC39A14 POR VDAC3 CHMP6 ATG7 CHMP5 SLC3A2 ATG5 DPP4 FTMT HSPB1 PCBP1 PHKG2 COQ2 LPCAT3 GCLC GPX4 GCLM FTL-1 GCH1 CP PRNP SLC7A11 GSS CBS;CBSL SPINAL CORD INJURY%WIKIPATHWAYS_20260710%WP2431%HOMO SAPIENS Spinal cord injury EGR1 LTB TNF AQP1 ARG1 ICAM1 CCND1 NR4A1 C1QB COL4A1 C5 GADD45A CCL13;CCL2 OMG CXCL8 LGALS3 RTN4R CHST11 ACAN PTGS2-2 CXCL2;CXCL3;CXCL1-1 MAG GDNF RAC1 NOS1 RTN4 RHOC BDNF MAPK1 GRIN1 SELP NTN1 CXCL10 MAPK3 E2F5 CDK1 VIM RB1 CCR2 ROS1 COL2A1 E2F1 FOS IFNG CDK4 TP53 EGFR FKBP1A SLIT2 PLA2G5 NOX4 PLA2G6 IL2 IL6 MYC NGFR FOXO3 LTB4R IL1R1 CASP3 MMP9 IL1B PLXNA2 CDKN1B PLA2G2A-1 CDK2 PPP3CA NOS2 TGFB1 EFNB2 IL4 ROCK2 EPHA4 XYLT1 AQP4 ZFP36 SEMA6A MIF PDYN CDC42 BCAN KLK8 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 PTPRA LEP CSPG4 BTG2 SOX9 NCAN ANXA1 TACR1 RGMA GJA1 MMP12 VCAN PRKCA GAP43 MBP IL1A CD47 AIF1 PTPRZ1 GFAP SLIT1 SLIT3 RHOA APEX1 CCNG1 TNFSF13B RHOB TLR4 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260710%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG1 PRKAG2 HMGCR PRKAG3 PRKAB2 PRKAB1 STK4 PRKAA1 PRKAA2 RHOC RHO TEAD1 TEAD2 TEAD3 TEAD4 MOB1A;MOB1B LATS1 LATS2 STK3 CCN2 YAP1-1 RHOA SAV1 CCN1 RHOD RHOB NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260710%WP4255%HOMO SAPIENS Non small cell lung cancer TP53 RASSF1 EGFR KIF5B RASSF5 BAK1 RXRG BID STAT5A STAT5B CCND1 CDKN2A STK4 ARAF BAX ALK RAF1 AKT2 AKT3 AKT1 FOXO3 GADD45A CASP9 CYCS-1 CASP8 CASP3 RET DDB2 HGF BRAF PLCG1 MET GRB2 PIK3CD RARB GADD45B PIK3CB HRAS RXRA SOS2 GADD45G POLK PDPK1 ERBB2 PRKCB PIK3CA STAT3 BAD SOS1 NRAS MAP2K2;MAP2K1 MAPK1 MAPK3 E2F2 E2F3 KRAS KIF5A TGFA RB1 PRKCA CDKN1A PRKCG EML4 FHIT E2F1 KIF5C PLCG2 JAK3 CRABP2 EGF CRABP1 CDK6 CDK4 RXRB LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260710%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB LDHA SLC1A2 SLC16A1 CA2 CA4 SLC2A1 SLC16A3 SLC16A7 NUDT14 SLC4A4 HK1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260710%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain AKT1 RAC1 MTOR MAP2K7 MAP2K6 PIK3CA MAP2K5 YAP1-1 RHOA GNAQ NFKB1 MAP2K3 MAP2K4 MAP2K2;MAP2K1 RAF1 MAPK1 PDK1 TRIO AMOT MAPK3 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260710%WP3935%HOMO SAPIENS Leptin insulin signaling overlap AKT1 IRS4 LEPR LEP SOCS3 SOCS1 PDPK1 STAT3 PIK3R3 INS;INS-IGF2 INSR IRS1 JAK2 IRS2 DGKZ PIK3CG SOCS2 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260710%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 AMDHD1 GPT2 FTCD GLUD1;GLUD2 HAL METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260710%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B3GALNT1 GALNT16 SGMS2 GALNT1 UGCG ST6GALNAC3 KDSR SGPP1 CERS3 B4GALT2 B4GALT1 CERK SGMS1 UGT8 B3GALT2 SGPL1 SPHK2 SGPP2 SPHK1 B3GALT1 B4GALNT1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy HIF1A DGAT2 FYN CAVIN1 DGAT1 BSCL2 GPAT3 LPIN1 LPIN3 PIK3CA CAV1 INS;INS-IGF2 IRS1 GRB2 LPIN2 ITGB4 AGPAT2 AKT2 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5365%HOMO SAPIENS 4p16 3 copy number variation CBL NELFB H3-3A SLBP UBE2J2 CLTCL1 ERI1 NSD2 TMEM129 FAM53A GAB1 NELFCD NELFA PIK3R1 NELFE SOS1 POLN BCS1L CKAP5 LETM1 TACC3 C4orf48 MAPK1 MAPK3 FRS2 NAT8L PLCG1 GRB2 FGFR3 FGF2 IL9 SIGNALING%WIKIPATHWAYS_20260710%WP22%HOMO SAPIENS IL9 signaling IL2RG IL9R IL9 STAT5A STAT5B PIK3R2 JAK1 STAT3 CDK9 PIK3R1 GRB2 MAP2K2;MAP2K1 MAPK1 JAK3 STAT1 MAPK3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260710%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2J2-1 GSTP1 COX8A EPHX2 COX5A CYP2C9;CYP2C19 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer JAG1 MED1 CDK8 PMAIP1 CCND1 RB1 CDH1 MACROH2A1 E2F1 TULP3 SOX4 CSRP2 CTNNB1 CDK4 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260710%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP1A2 HSD17B10 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD17B3 HSD17B7 HSD17B4 HSD17B1 HSD17B2 CYP19A1 COMT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B8 CYP1B1 CYP2C9;CYP2C19 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260710%WP5506%HOMO SAPIENS Disorders of NAD metabolism CD38 NADSYN1 BST1 NAXE NAXD CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260710%WP4504%HOMO SAPIENS Cysteine and methionine catabolism AHCY MTR-1 SQOR SUOX GOT1-1 ETHE1 MAT1A BHMT CTH CDO1 CSAD GSS GCLC MPST CBS;CBSL EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260710%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 FOXO1-1 TNF TLR7 STAT5A IL21 IL2 IFIT2 IFNAR2 IL6 MAF C3-1 IRF4 IRF8 PTPRC CD82 LOC110384692;C4A;C4B_2;C4B LOC102723996;ICOSLG CR2 BACH2 BLNK TMSB10 FCRL5 PAX5 BCR EBI3 CD1D CD79A TBX21 BTLA SLAMF7 AICDA GPR183 CD69 CD22 CCL21 SELL CD40 XBP1 BCL6 ITGB2 CXCL12 CXCL13 ITGAX MS4A1 SH2D1A IFITM3;IFITM2;IFITM1 CXCR5 IL10 CCL19 CD80 IL4 IL12A PRDM1 MFGE8 HSPA8 CXCR4 SYK PDCD1 ISG15 ICOS ETS1 CR1L;CR1 CCR7 CD19 CD40LG PTCRA ZEB2 TNFSF13B IFNG TLR4 CRP IRINOTECAN PATHWAY%WIKIPATHWAYS_20260710%WP229%HOMO SAPIENS Irinotecan pathway UGT1A1;UGT1A6 ABCG2 BCHE CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 CES2 CES1 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260710%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 TP53 MMP9 CHI3L1 SOCS3 BAX MYC E2F1 CDH1 IL6ST STAT3 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260710%WP247%HOMO SAPIENS Small ligand GPCRs PTGFR GPR50 TBXA2R CNR2 CNR1 MTNR1A LPAR1 MTNR1B PTGER4 PTGER1 PTGER2 PTAFR PTGER3 PTGIR S1PR2 S1PR1 S1PR3 PTGDR S1PR4 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA OPN4 GLUD1;GLUD2 SH3GL3 SMC3 ADAM10 BMPR1A GPR15 SH2D4B ERBB4 NFKB1 ADIRF TNFSF11 BUB1B LDB3 GHITM IQUB ROPN1L FAM25A;FAM25C;FAM25G;FAM25E-1 RSPH6A VEGFA GRID1 SIRT4 DNAJB13 RAD21 NME5 NRG3 CDHR1 MMRN2 DYDC2 DYDC1 RGR SF3B4 RSPH9 STAG1 SNCG C10orf99 RSPH4A SUSD2 SMC1A RSPH3 ZMYND11 TSPAN14 PDS5B RSPH1 PDS5A LRIT2 SHLD3 AFG3L2 LRIT1 PRXL2A SHLD2 SHLD1 WAPL CCSER2 BMP2 MAD2L2 MAS1 MAT1A ACTN2 PPARG ATR SIGNALING%WIKIPATHWAYS_20260710%WP3875%HOMO SAPIENS ATR signaling RAD9A HUS1 CHEK1 RPA2 RAD1 RPA3 TOPBP1 RPA1 RAD9B ATRIP ATR 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome TP53 HBEGF SDCBP CD4 NDST1 SHH CD82 GLI3 ITGB2 MS4A1 CLOCK B4GALT4 ITGA4 LEF1 ITGA3 ARNTL ITGA6 EXT1 ITGB1 CRY2 EXT2 TIMP1 HLA-DMA HLA-DMB SPPL2C CHST6 ACCS CD151 ALKBH3 C11orf96 C11orf94 LARGE2 CD53 NRXN1;NRXN3;NRXN2 SLC35C1 MAPK8IP1 SLC25A17 B3GNT7 HLA-DRA PEX3 PRDM11-1 LGALS3BP CD63 IGSF8 REST PHF21A CD19 ALX4 CHST1 TP53I11 PEX16 SYT13 VANGL1 B4GAT1 TSPAN18 IZUMO1-1 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260710%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL6 ACSL5 FABP1 LDLR FABP2 FABP3 FABP4 APOA4 APOC1 APOC2 LRP1 SLC27A4 MYLIP PCSK9 ACSL1 APOE APOB VDAC1 LDLRAP1 ACSL3 SOAT1 SOAT2 ABCA1 LIPA SLC27A1 STARD3 OSBPL5 SORT1 SCARB1 NPC2 SLC27A3 STAR SLC27A2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation RUNX1 SEC14L2 MUC1 MXI1 NFE2 ACVR1B RIOK3 FLI1 GP9 STAT5A CIITA SPI1 TNXB IL6 ITGA2B ITGB3 CSF1 MYB NFATC2 THRB IL1B KITLG FOSB RHOH LYL1 NOTCH1 LEF1 IRF5 GATA2 NCKAP1L IL5 TPO CSF3 CSF2 EPO CXCR4 VAV1 IL3 CD34 PIM1 KLF1 LMO2 GATA1 IL1A TRAF3IP3 IKZF1 FOS HMGN5 TRIM29 KCNH2 HES6 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260710%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM TP53 RASSF1 PCNA BAK1 MDC1 BID DCLRE1C RIF1 KAT5 EXO1 CDKN2A MCPH1 HSF1 TP53BP1 RAD17 TRIM28 BAX UPF1 MDM2-2 SMC3 RNF8 APAF1 FANCD2 CDK5 CASP9 CHEK2 CASP3 CHEK1 MRE11 CDC25C BRCA2 RAD52 RAD50 RAD51 NBN PRKDC ATM TP73 BLM RAD9A BRCA1 PARP1 ATR SMC1A NABP2 LATS1 ABL1 ATF2 TERF2 STK3 YAP1-1 ACTL6A E2F1 TRAF6 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260710%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons CDK5 PPP1CA ADCY2 CHRNB2 GNG2 DRD3 DRD4 CHRNA3 TH KCNK9 SLC18A2 CHRNA5 DRD2 CHRNA4 CHRNA6 PPP1R1B KCNK3 PRKACA-1 DDC GNB1 GNAI1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5406%HOMO SAPIENS 13q12 12 copy number variation RAC1 MAPK8 DAG1 DMD MAPK9 RTN4 ADIPOQ MIPEP C1QTNF9B;C1QTNF9 ATXN1 FLNC SACS SNTA1 LINGO1 CDC42 DTNA SPATA13 SSPN SNTB1 TRAF1 TRAF3 SGCD SGCA SGCB SGCG RTN4R RHOA TRAF2 MAG TNFRSF19 TRAF5 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260710%WP5236%HOMO SAPIENS Markers of kidney cell lineage EGLN1 HNF1A KDR DES FGF8 NT5E WNT5A CITED1 TCF21 RSPO3 RSPO1 DACT1 EMX2 FOXD1 OSR1 KCTD1 EGLN2 SIX1 SFRP1 TSHZ3 WNT4 EGLN3 TBX18 TLX1 FAT4 VSX2 SALL1 PECAM1 SIX2 EYA1 DCN GDNF NOTCH1 AP2B1 PDGFRB TNC PBX1 PAX2 SMAD1 SMAD5 EPO ACTA2 BMP4 NTN1 HNF4A JAG1 ALDH1A2 KIT NPHS1 NPHS2 WT1 NOTCH2 REN FGF7 BMP7 LHX1 AXIN2 HNF1B WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260710%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia RARA FZD6 LEF1 LRP5 PML CCND1 BCL9 JUP CSNK1A1 APC MYC PPARD LRP6 AKT1 WNT1 SALL4 FLT3 PYGO1 RUNX1T1 ZBTB16 WIF1 CTNNB1 DKK1 AXIN2 GSK3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260710%WP5124%HOMO SAPIENS Alzheimer 39 s disease TNF SLC25A5 ULK1 RAF1 IRS4 FRAT2 APC2 PTGS2-2 CALM1 GSK3B PIK3CD NOS1 PIK3CB ITPR1 PSMD8 PIK3CA PSMD7 RTN4 ADAM17 PIK3R3 CACNA1C PIK3R1 GNAQ GRIN2A NRAS CHRNA7;CHRFAM7A RELA GRIN2C VDAC1 GRIN2B GRIN1 MAPK1 GRIN2D MAPK3 KRAS MTOR PSMC5 MAP3K5 TRAF2 TNFRSF1A FZD6 FZD9 MAPK8 SLC25A6 MAP2K7 FZD10 BID TPTEP2-CSNK1E;CSNK1E PSMC6 IRS1 IL6 PSMC4 FAS WNT5B WNT5A PIK3R4 WNT6 PSMD12 DVL1 PSMD13 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A WNT3A INSR IL1B NFKB1 WNT2B WIPI1 AXIN1 WNT16 PIK3C3 VDAC2-1 MAPK9 WNT11 VDAC3 PLCB3 BAD PLCB4 WNT7B WNT7A ITPR2 ULK2 ITPR3 TUBAL3 APC PLCB1 CHUK PLCB2 IKBKB PPP3CC TUBA1C TUBA1A ATP2A3 TUBB1 ATP2A2 TUBA3E;TUBA3C-1 TUBB2B;TUBB2A IL1A FZD3 TUBB4B TUBA4A TUBB4A;TUBB;TUBB8B;TUBB8 CTNNB1 IRS2 AGER AXIN2 TUBB3;TUBB6 CACNA1D CACNA1F TUBA8 KIF5B GPR83 CACNA1S ATF4 FZD1 LRP1 CSNK1A1 FZD7 FZD8 CYBB SFRP4 PPP3R1 NOX1 APAF1 CDK5 PSMD2 ADAM10 MME CALM3;CALM1 CSNK2B CALM2 APOE LRP6 CSNK2A2 SNCA WIPI2 ATG14 CSNK2A1;CSNK2A3 APH1A APH1B ATG2A BECN2 CALML6 CALML3 CALML4 LPL NOX4 ARAF SLC25A4 AKT2 AKT3 CAPN2 AKT1 CAPN1 CASP9 CYCS-1 CASP7 CASP8 CASP3 PIK3R2 FADD CSF1 BRAF RB1CC1 PSMD9 DKK4 PSMD6 PSMD4 PSMD3 XBP1 PSMD1 PSMC2-1 DKK2 EIF2AK3 NRBF2 EIF2S1 DKK1 ATG2B ERN1 ATG13 DDIT3 IDE PSMA5 PSMA6 PSMA3 ATF6 PSMA4 PPP3CA PSMA1 PPP3CB PSMA7 BECN1 PSMA8 HRAS PSMB6 NOS2 PSMB7 PSMB4 PSMB5 PSMB2 LRP5 FZD5 EIF2AK2 PSMB3 AMBRA1 PSMB1 APBB1 FZD2 PSMA2-1 PSMC3 PSMC1 ATG101 RYR3 CDK5R1 INS;INS-IGF2 PPIF PPID RTN3 PSMD14 KLC1 KLC4 KLC3 KLC2 MAP2K2;MAP2K1 NAE1 SEM1 MCU ATP2A1 ADRM1 SLC25A31 MAPK10 HSD17B10 KIF5A BACE1 KIF5C PSENEN APP NCSTN PSEN2 GAPDH-1 MAPT PSEN1 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260710%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling KANK1 SLC7A1 APOLD1 TRPC1 FGD5 HSPA1A;HSPA1B CTNND1 PLOD3 RPL10A ARF4-1 SDCBP GRB10 ICAM1 SEMA6D CCND1 ARMCX1 RAB37 KDR FSCN1 NR4A1 MAPKAPK5 RPS6 DSC1 LRRC59 STIP1 CCT7 IGFBP7 TXNDC5 SDF2L1 QKI TFCP2 RCAN2 AP2A1 TPP1 CALU EIF4G2 FHL2 RAF1 NRARP ELOC-1 TAOK2 CAPZB ADAMTS1 ACP1 ADAMTS9 TRPC3 SARS1 ACACA RPL13A-1 SLC25A11 PBXIP1 PPM1G DNAJB4 SLC25A25 CDC42BPB PTPN14 MYO1C PTPN9 TRAF3IP2 NFATC2 RPL18A SYNJ1 UBAP2L CHAC1 RPS11 PLA2G4A ATP6V1E1 TMEM170A KATNAL2 SPIRE1 ZNF555;ZNF57;ZNF556 PTGS2-2 PFN1 ATP6V0D1 EPB41 FXR2 DHX36 SIAH2 FUT1 MICAL2 STAM SRPK1 EPRS1 DHX29 NRP2 RAC1 FAF1 CCDC124 SRF PTPRJ HERPUD1 P4HB CLIC1 RHOJ FJX1 RPS6KA5 PTMA NEXN GATA2 CRIP2 STAT3 GPC1 COPG1 FHOD1 TMOD1 CREB1 TMOD3 DOK1 HGS MAPKAPK2 HDAC4 PSMD11 HTRA1 SCUBE2 ZC3H15 PRKCD RELA TBCA BRD4 CAMKK2 NR4A3 PAK1 DNAJA1-1 GRSF1 C15orf39 MAPK1 LDB2 RND1 LRRFIP2 MAPK3 ARHGEF15 SHROOM2 PTPN6 EPN1 RCN1 MTOR PNP-1 USP10 MKNK1 FAM120A RPS6KB1 RBM39 PDE4DIP TAL1 FMNL3 ATF2 ELK1 PRKCI ENG MAP3K5 MAP2K3 MAP2K4 FOXO4 PRKCZ HSP90AA1 MMP2 STAT1 HBEGF MAPK8 PGF MAP2K7 MAP2K6 JUN MAPK14 MAPK12 BCL2 FAS BCL2L1 ITGB3 PPP2CB;PPP2CA FLT1 CDH5 CCN2 ACKR3-2 VEGFA S1PR1 ARRB2 PRKCB PLCB3 ITGB1 ROCK1 ROCK2 ARPC5L GPX1 ACTG1 CDC42 TUBA1C ETS1 OCLN-1 ABL1 FYN PRKG1 NCK1 PRKCA NOS3 RHOA NCL-1 BMP10 TUBB4A;TUBB;TUBB8B;TUBB8 CTNNB1 EZR TNFRSF25 CBL STAT6 TKT PTPN11 PGD GLUD1;GLUD2 CSRP1 INPP4B SOD2 PRKD2 PRKD1 TXN CCL13;CCL2 CXCL8 LIMK1 F3 YWHAE PLAUR HSPB1 MYH9 RAB4A JAG1 RAB11A NR4A2 INPP5K NAP1L1 NUMB SHB MMP14 IQGAP1 PTK2B PLA2G5 BMX NOX4 AFDN NAPA CAPN2 AKT1 AP2S1 VCL ARF6 PXN PIK3R2 RAP1B RAP1A CAV1 PTK2 GRB2 ITGB5 EIF2AK3 ERN1 TXNIP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 ITGAV PPP3CA HRAS PDPK1 HDAC9 HDAC7 HLX VAV2 RAPGEF1 RCAN1 CRK MYH11 TPM3 SRC MAP2K2;MAP2K1 CSRP2 CSK TEAD4 PRKCE PAK2 MYL2 BCAR1 SHC1-1 EPHA2 ASCC3 GAPDH-1 CLTC EGR1 FN1 MOV10 SRP54 LMAN1 TNXB ALDOA LDHA PGK1 HBD;HBB P4HA2 SHC2 ITCH CNP TFAM-1 GSK3B PTPN1 ADAM9 PIK3CA PRKAA1 PRKAA2 PIK3R1 ALB PABPC1;PABPC3 MLST8 FGB FGA FGG EIF3H EIF3F EIF3D AKT1S1 BIRC5 HDAC1 SET-1 EIF4E CREBBP MAPKAP1 RICTOR PLAU MDM2-2 FOXO3 EIF4G1 HDAC5 NFKB1 MEF2C SMARCA2 MAPK9 HMGB1-1 ANXA1 SLC8A1 GJA1 PTPRZ1 CACNA2D1 DECR1 CCN1 CCRL2 PRDX2 NFKBIA AMOT FOXO1-1 CFL1 CTNNA1 EIF2A ATF4 CYBB TMSB10 ADAM10 FRS2 NOTCH4 DLL4 PLCG1 EPHB2 ERG NDRG1 MMRN2 VPS39 ARNT GAB1 RHOC ADRB2 FLNB EPS15 TPCN2 PRKRA KL OCRL BSG EGR3 RAB5A PPP1CA CYCS-1 DPM1 FADD FBXW11 SELE PSMD4 DKK1 ACACB CALR-1 NFATC1 DNAJB9 PDIA6 IDH2 WASF1-1 RPL7 LUC7L BMP2 IER5 ACOT9 SND1 EWSR1 BIN1 RPL27 RPL26 FLII ABCF2-H2BE1;ABCF2 GIGYF2 MYO6 PRRC2C TRIP4 LARP7 PRDX6 RPL5-1 GIPC1 HYOU1 FARSB KCNC3 EEA1 NCF1 IGFBP3 RACK1 NCF2 PBK RPLP2 ELOA SH3BGRL3 CGNL1 DUSP5 SSR4 SSR3 MMP10 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP75%HOMO SAPIENS Toll like receptor signaling IRF7 MAPK8 TNF MAP2K7 TLR7 MAP2K6 IFNB1-4 JUN MAPK14 MAPK12 IFNAR2 MAPK13 MAPK11 IL6 MAP3K7 IFNAR1 AKT2 AKT3 AKT1 CASP8 TRAF3 RIPK1 MAP3K8 CCL4L2;CCL4L1;CCL4 FADD CXCL8 IL12B TICAM2 CXCL11 IL1B NFKB1 CD40 TICAM1 TOLLIP TAB3 TAB2 RAC1 IKBKE IRAK4 TIRAP TLR1 MAPK9 TLR9 CD86 TLR8 CCL3L1;CCL3L3;CCL3;CCL18 IRF5 CD80 TLR6 TLR3 TLR2 IL12A IRAK1 CHUK RELA MAP2K2;MAP2K1 IKBKB LY96 CCL5 MAPK1 IKBKG MAPK3 CXCL10 MAPK10 TAB1 CD14 MYD88 CXCL9 TBK1 LBP MAP2K3 MAP2K4 IRF3 NFKBIB SPP1 FOS NFKBIA TLR5 STAT1 TRAF6 TLR4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260710%WP2333%HOMO SAPIENS Trans sulfuration pathway DNMT1 AHCY CTH MAT2B MTR-1 CSAD MPST CBS;CBSL GCLM GOT1-1 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260710%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 NRIP1 FN1 STAT5A AREG CCND1 ERBB2 VIM PGR TIMP1 FOSL1 ESR1 MYC EGF KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260710%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy ITPR1 DAG1 SCN8A SCN2A SNAP25 ANK3 PRRT2 KCNQ2 FGF13 PRKACA-1 FGF12 VAMP2 PRKCE KCNQ3 NEDD4L RAB11A NEDD4 RAB1A TRAPPC3 TRAPPC2;TRAPPC2B GIGYF1 CAMK2A TRAPPC6B KCNQ1 KCNQ4 KCNQ5 SCN4B STX1A CALM1 AKAP5 BACE1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCR MVD IDI1 MVK ACAT1 ACAT2 HMGCL HMGCS1-1 PMVK IDI2 FDFT1 FDPS GGPS1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260710%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response KNG1 ITGA4 TNF ICAM1 CXCL8 SELPLG VCAM1 IL1A C6 C7 ITGB1 IL6 C3-1 ITGB2 C5 ITGAL SELP SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260710%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins TRNAU1AP SELENOO SEPSECS SELENON SARS2 SELENOS FABP1 SCLY SELENOT JUN DIO1 DIO3 RELA GPX1 TXNRD2 SP1 TXNRD1 GPX4 GPX6 SP3 SARS1 SELENOP NFKB1 CREM RPL30 SELENOK CTH SELENOI NFE2L2 SELENBP1 SEPHS1 SEPHS2 PSTK FOS EEFSEC POU2F1 TXNRD3 SECISBP2 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260710%WP4630%HOMO SAPIENS Measles virus infection IL2RG HSPA1A;HSPA1B MX1-1 STAT5A TLR7 STAT5B CCND1 IL2RA IL2RB CD3G CD3E IFNAR2 IFIH1 STAT2 CCNE1 OAS1 MSN IFNAR1 APAF1 CBLB TRAF3 IL12B CD28 PIK3CD PIK3CB PIK3CA STAT3 PIK3R3 IRAK1 PIK3R1 CLEC4M;CD209-2 CSNK2B RELA HSPA8 MAVS RAB9A CSNK2A2 EIF2AK1 MYD88 JAK1 CSNK2A1;CSNK2A3 FASLG DDX58 EIF3H NFKBIB IRF3 FOS CDK6 IRF9 STAT1 CDK4 TRAF6 TP53 IRF7 MAPK8 BAK1 SLAMF1 BID HSPA6 IFNB1-4 HSPA2 JUN EIF2AK4 ADAR OAS3 RCHY1 HSPA1L IL2 NECTIN4 RAB9B IL6 CCND3 CCND2 BCL2 FAS BAX BCL2L1 MAP3K7 TRADD CASP9 CYCS-1 CASP8 CASP3 PIK3R2 FADD CCNE2 IL1B NFKB1 NFKB2 TP73 EIF2AK3 EIF2S1 CDKN1B TAB2 CDK2 BBC3 TNFAIP3 IKBKE IRAK4 MAPK9 EIF2AK2 TLR9 TLR2 IL12A BAD CHUK IKBKB CD3D IKBKG MAPK10 TBK1 IL1A RACK1 NFKBIA JAK3 TYK2 TLR4 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260710%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection CBL TNF MAP2K7 JUN CD4 IL2 CHP1 AHSA1 DLG1 MAP3K7 RAF1 PDK1 PTPRC AKT1 MAP3K8 NFATC2 PLCG1 NFKB1 ITK CD28 GRB2 CALM1 GSK3B DAG1 CD8A MAPK9 IL10 PIK3CA CARD11 IL4 IL5 CTLA4 MAP3K14 SOS1 CHUK MAP2K2;MAP2K1 IKBKB PAK1 CD3D CSF2 GRAP2 IKBKG BCL10 MAPK3 PDCD1 LCP2 MALT1 PRKCQ ICOS PTPN6 LAT FYN NCK1 CD40LG ZAP70 LCK FOS RRAS NFKBIA IFNG CDK4 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260710%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PIK3CD EGFR MMP1 PIK3CB HRAS PLA1A PIK3CA PTGER4 NRAS PTGES2 PTGER1 SRC ESR1 PTGER2 PTGER3 MAPK1 AKT2 AKT3 MAPK3 AKT1 KRAS CYP19A1 BRAF PTGS2-2 PIK3CG FRAGILE X SYNDROME%WIKIPATHWAYS_20260710%WP4549%HOMO SAPIENS Fragile X syndrome CLTC GRIA1 GRIA2 TARBP2 PTPN11 MAP1LC3B2;MAP1LC3B-1 DICER1 TSC1 GABRB2 TELO2 SH3GL3 AP2A1 RAF1 AGAP2 GRM5 GABRG3;GABRG2 DLGAP3 PICK1 CNR1 CAMK2A PLCG1 SHANK1 GABRA1 DEPTOR RPTOR PTEN CLTB GAD1 PIK3CB AP2B1 GRM1 DAG1 ITPR1 SYNGAP1 ARC CLTCL1 CAMK2B CLTA GAB1 CREB1 DNM1 GRIN2A NTRK2 HOMER1 BDNF GRIN2B MAPK1 GRIN1 RHEB DLG4 EIF4EBP2 NF1 KRAS DNM2 MTOR MKNK1 RPS6KB1 CAMK4 CAMK1 EEF1A1 MLST8 AKT1S1 CYFIP1 FMR1 EIF4E CDKN2A AP2M1 KCND2 CPT1A CYFIP2 ARAF SH3GL1 GRIP2 ALDH3A2 MAP1B PDK1 TBC1D7;TBC1D7-LOC100130357 HOXB8 RAP1GAP ARHGAP32 AGO2 AKT1 ABCD3 SLC6A1 PPP2R5B KCNC1 TECR EIF4G1 DUSP3 PPP1CA ALDH5A1 AP2S1 EPS8L1 PTPN5 TSC2 TTI1 BRAF MMP9 MECP2 GRB2 GABRD AKAP5 PPP3CA SOS1 PLCB1 EPHA4 SRC MAP2K2;MAP2K1 PRKACA-1 EIF4A1 PRKAR1A FYN SHC1-1 SLC16A1 PRKCA ABAT GRIP1 GPHN APP HCN1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260710%WP5604%HOMO SAPIENS Sickle cell disease IL18 IL1B HBD;HBB HBA2;HBA1 TLR4 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1A2 FMO3 MSRA MSRB2 MSRB3 CYP1B1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260710%WP45%HOMO SAPIENS G1 to S cell cycle control TP53 PCNA CCND1 CDKN2A CDC25A CCND3 CDKN1C CCND2 CCNE1 MYC CCNH MDM2-2 POLE GADD45A CREB3 ATF6B CREB3L3 CREB3L4 RPA2 CREB3L1 RPA1 MYT1 CCNE2 CDK7 POLE2 ATM ORC5 RPA3 CDKN1B ORC4 ORC6 ORC1 ORC3 MNAT1 CDK2 ORC2 MCM7 CCNB1 CREB1 CCNA1 CCNG2 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 MCM2 CDC45 E2F2 E2F3 CDKN2D CDK1 PRIM2 WEE1 PRIM1 RB1 POLA2 CDKN1A E2F1 CDKN2B CDKN2C CDK6 CDK4 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260710%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CREBBP LRP5 PORCN CTNNB1 LRP6 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260710%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome PLK1 GATA3 MYH11 DCTN6 DCTN1 DCTN4 DISC1 PLAG1 RAP1A ACTR1A ACTR1B PLAGL1 ABCC1 KIAA0753 BMERB1 DCP2-1 OFD1-1 NDE1 ABCC6 MARF1 DCP1A CEP20 ACTR10 RAPGEF4 PAFAH1B1 SIGNALING LIPIDS%WIKIPATHWAYS_20260710%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B PLA1A CYP8B1 PLCB1 GPX4 CYP2C9;CYP2C19 ALOX5 CYP27A1 ALOX15 HPGD ALOX12 LTC4S FADS2 LTA4H CYP7B1 PTGDS CYP2B6 TBXAS1 PTGS2-2 PTGES CYP7A1 PRXL2B EPHX2 CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260710%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases DUSP1 PPP3CA RXRA SMAD2;SMAD3 TNF NR3C1 MAP2K6 VDR MAP3K1 MAPK14 SMAD4 NFKB1 IL6 MAP2K3 CHUK NFATC1 RELA IKBKB NFKBIA MED14 PPP3R1 IKBKG EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260710%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX5 ALOX15 ALOX12 JMJD7-PLA2G4B;PLA2G4B LTC4S PTGS1 LTA4H GGT1 PTGDS PLA2G5 PTGIS ALOX5AP PLA2G6 PLA2G4A ALOX15B TBXAS1 DPEP1 PTGES2 PTGS2-2 PTGES PRXL2B CBR1-1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260710%WP170%HOMO SAPIENS Nuclear receptors ESRRA NR2F1 NR0B1 RARA NR2F2 RARB NR5A1 NR5A2 RXRA RXRG ROR1 PPARA NR4A1 AR NR1D2 ESR1 NR2F6 NR1H2 PPARD NR1H3 NR1I2 HNF4A RORA NR4A2 NR3C1 RARG VDR PGR ESR2 THRB THRA RORC NR2E1 NR2C2 NR1I3 RXRB ESRRB PPARG RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260710%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis AKT1 TP53 FOXO3 EGFR MTOR RPL11 RIOK2 RIOK1 PIK3CA MLST8 MAPKAP1 RICTOR AKT2 AKT3 PTEN ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2858%HOMO SAPIENS Ectoderm differentiation SGSM3 ZNF219 TRIM33 MYORG DMD SDCBP CTNNA2 BCOR JUP FZD8 FHL2 PGM1 CCL13;CCL2 GLI3 ELOVL2 PRKAG2 KRT6B;KRT6C;KRT6A NLK PPARD LDB2 PODXL HDAC6 MKS1 SNCA UBTF GLB1 SKIL SPRY2 FGFR2 OGT-1 CTBP1 ROR2 MYC ELOVL4 SHH TNFRSF11B SMURF1 BMPR1A WNT1 TFAP2A TFAP2C SMAD4 SOX2 ZBTB16 MECP2 PLXNA2 ABCC4 EDA2R PDE7A GATA6 NR2F2 NLGN1 ARHGDIG CELSR2 FZD5 TSKU FZD4 NARS2 ANKS1B CDON ZFHX4 TCF7L1 KCNK10 GRAMD1B-1 TLE5 MZF1 ASTN1 LY6E CDH8 ARX STC1 CDH6 ARHGAP15 ZBTB2 NFATC1 ST8SIA4 HESX1 ZBTB7B GAS2L1 GREB1 BMP4 POU2F2 PAN2 PLCXD3 PTPRB MAFB PPFIBP2 CCDC88C PIM1 PI4KA PAX6 CCDC130 NUMA1 TOX3 FYN HMGB2 AHI1 WDR44 RGMA PHF8 SIX6 BOC RAB8B BCAS3 TSC22D1 SORCS1 IQCJ-SCHIP1;SCHIP1 BAZ1A FOXL1 HDAC10 CLDN11 LHX1 ARHGAP10 KIFC3 CTNND2 STX16 RRBP1 NF2 EDA JAKMIP1 TRPM2 SERPINB6-2 CLVS1 CAP2 CTNNB1 FOXA2 PAX3 TTC14 C1GALT1 PTPN13 SOCS2 VAX2 RIT1 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260710%WP2197%HOMO SAPIENS Endothelin pathways CALCA CALCRL CNN1 EDN1 RIIAD1 RAMP1 GNA15 ADCY10 ECE1 ADRB1 NPY PLCB1 ADRA1A GNAS-1 MAP2K2;MAP2K1 GNB5 PTGIR RAF1 EDNRA MAPK1 EDNRB GNAI1 MYL1 ATP2A2 CAD NOS3 PRKCA GNG13 CALM1 NPY1R MYLK GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260710%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGAT2 PTDSS1 PLA2G1B GPAT4 GPAM CDS1 DGAT1 PISD AGPAT4 PTDSS2 CHKB ETNK1 PNPLA3 PCYT2 PNPLA2 CRLS1 CDIPT PEMT CHPT1 PLD1 DGKZ PCYT1A HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260710%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis RPS6KA5 DRD1 CAMK2B NRXN2 CAMKK1 MAPK14 SYT2 CREB1 HNRNPL SYT12 CCND2 BCL2 CAMKK2 BDNF MAPK1 PPARGC1A NRXN1;NRXN3;NRXN2 NCAM1 CAMK4 PRKCA CAMK2A NRXN3 CALM1 PRL NGF RPS6KA1 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260710%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells AXIN1 EGFR HRAS ERBB2 TGFB1 PROM1 APC NRAS MFGE8 RAF1 WNT5A AKT1 KRAS MTOR TGFA TSPAN8 SMAD2;SMAD3 TGFBR1-1 SMAD4 HGF WNT3A TGFBR2 TGFBR3 DKK4 MET TGFB2 TGFB3 CTNNB1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP581%HOMO SAPIENS EPO receptor signaling SOCS1 CISH STAT5A STAT5B RASA1 STAT3 SOS1 PTPRU IRS1 SRC MAP2K2;MAP2K1 RAF1 EPO MAPK1 PDK1 PTPRC MAPK3 AKT1 EPOR SHC1-1 GRB2 JAK2 IRS2 PIK3CG STAT1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260710%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling TP53 KLK3;KLK2 FOXO1-1 PDGFRB CREBBP CCND1 PIK3CA BAD AR SOS1 BCL2 MAP2K2;MAP2K1 PDGFA RAF1 MAPK1 AKT3 MDM2-2 IKBKG TCF7 KRAS CASP9 MTOR CREB3L1 CDKN1A NFKB1 GRB2 CDKN1B CTNNB1 NFKBIA GSK3B GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260710%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis MPC2 DLAT TPI1 PGAM1 GOT2-1 PGAM2 PKM ALDOC ALDOB ALDOA DLD FBP1 FBP2 LDHB LDHA GCK PGK1 PCK1 PDHA1 PKLR MDH1 MDH2 G6PC1 GOT1-1 GPI LDHA;LDHC PFKL PC SLC2A2 ENO1 SLC2A5 ENO2 SLC2A1 ENO3 SLC2A4 PFKM HK2 PFKP HK1 HK3 LDHAL6B GAPDH-1 MPC1 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260710%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCD1 PIK3CD PIK3CB ITPR1 TNF PLCE1 PIK3CA MAPK14 IL12A PLCB3 PLCB4 IL6 CHUK PLCB1 PLCB2 RELA IKBKB MAPK1 AKT2 AKT3 IKBKG MAPK3 AKT1 CXCL8 RETN IL12B PLCG1 NFKB1 PLCG2 NFKBIA PIK3CG PLCD3 PLCD4 IL19 SIGNALING%WIKIPATHWAYS_20260710%WP5422%HOMO SAPIENS IL19 signaling RAC1 MMP1 MAPK8 IL19 SOCS1 TNF STAT6 SOCS5 TGFB1 STAT3 IL4 CCNB1 MAPK14 MUC5AC IL20RA IL20RB CXCR4 MAPK1 ACTA2 MAPK3 AKT1 CCL11 JAK1 NFKB1 IL4R TNFRSF1A COL1A1 STAT1 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260710%WP5428%HOMO SAPIENS FGFR4 p G388R signaling IL10 FGFR4 STAT3 CREATINE PATHWAY%WIKIPATHWAYS_20260710%WP5190%HOMO SAPIENS Creatine pathway OAT GATM GAMT CKB SLC6A8 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260710%WP5304%HOMO SAPIENS Cholesterol metabolism CETP MTTP APOA2 IDI1 APOA1 MVK FABP2 MSMO1 DGAT1 LPL LCAT HSD17B7 APOA4 ACAT2 TM7SF2 HMGCS1-1 LIPC EBP APOC1 NSDHL CD36 APOC2 LRP1 PMVK SLC27A4 SC5D PLTP LBR FDFT1 TSPO MYLIP ANGPTL3 FDPS LRPAP1 APOC3 CIDEB VAPA DHCR24 LSS SQLE CYP27A1 SOAT1 MVD DHCR7 ABCA1 MGAT1 SCARB1 ABCG8 ABCG5 ANGPTL8 HMGCR ABCB11 NPC1L1 LDLR PCSK9 LIPG APOE VDAC1 SAR1B APOB LDLRAP1 LIPA NPC1-1 STARD3 OSBPL5 CYP7A1 SORT1 NPC2 STAR APOH CYP51A1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4224%HOMO SAPIENS Purine metabolism and related disorders PNP-1 MAT2A PRPS1 XDH ADSL AOX1 ATIC RRM2B ADA IMPDH1 TPMT HPRT1 ADSS2 PPAT GART MOCOS DGUOK AMPD1 PFAS PAICS APRT GRM5 ITPA BENZENE METABOLISM%WIKIPATHWAYS_20260710%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH MPO CYP2E1 GSTM1;GSTM2-1 NQO1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260710%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4B1 CYP2S1 CYP1A2 CYP1A1 CYP8B1 CYP26B1 POR CYP4V2 CYP2W1 CYP2R1 CYP24A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP46A1 CYP11B1;CYP11B2 CYP20A1 CYP2D6;LOC107987479;LOC107987478-1 CYP1B1 CYP2C9;CYP2C19 CYB5R2 CYP27A1 CYB5R1 CYP39A1 CYB5R4 CYP2U1 CYB5R3 CYB5A CYP2E1 CYP7B1 CYP4F22 CYP19A1 CYP27B1 CYP2B6 CYP2J2-1 CYP4X1 CYP11A1 CYP2C18-1 CYP7A1 CYP17A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2F1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP51A1 CYP26A1 CYP27C1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260710%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway TREM1 PIK3CD RAC1 CYBA PIK3CB VAV3 PIK3C3 VAV2 PIK3CA NCKAP1L PIK3R3 PIK3R1 PIK3R6 CYBB C1QB ARPC1B HCK SYK VAV1 TYROBP PTPN6 LAT TREM2 FCGR1A LYN FCER1G PIK3R2 SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 C1QC NCF1 ITGAM NCF2 NCF4 ITGB2 PLCG2 PIK3C2A PIK3CG RAC3 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260710%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAPK8 CYP2E1 MAFG NFE2L2 MAP2K2;MAP2K1 MAFF SP1 MAFK FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260710%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 CETP SEL1L APOA2 APOA1 LDLR LPL LCAT APOA4 APOA5 LMF1 LIPC APOC2 LRP1 PLTP GPIHBP1 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260710%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3CD EGFR PIK3CB HRAS ERBB2 PIK3CA PIK3R3 PIK3R1 PIK3R6 NRAS RAF1 MAPK1 AKT2 AKT3 MAPK3 PIK3R4 AKT1 PIK3R5 KRAS PIK3R2 ERBB4 ERBB3 PIK3C2G PIK3C2A PIK3CG PIK3C2B OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260710%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 ATP5MC2 NDUFB1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 ATP5MG ATP5ME DMAC2L ATP5PF NDUFA8 NDUFA7 NDUFA6 ATP5PD ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 ATP6AP2 NDUFA4L2 NDUFB10 NDUFS8 NDUFS3 NDUFV1 NDUFA9 NDUFA4 NDUFA5 GZMH;GZMB-1 ATP6AP1 NDUFA11 NDUFA10 NDUFC1 NDUFS7 NDUFS6 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP4159%HOMO SAPIENS GABA receptor signaling GABRA4 GAD1 AP2B1 GABRB3 GABRB2 GABRB1 AP2M1 AP2A1 AP2A2 SLC6A1 AP2S1 GABRG3;GABRG2 GAD2 GABBR1 SLC32A1 ALDH9A1 ABAT GABRE GABRD GABRQ GABRA2 GABBR2 GPHN GABRP GABRA1 GABRA6 SLC6A11 GABRA5 GABRA3 GABRG1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260710%WP5293%HOMO SAPIENS Acute myeloid leukemia MPO RUNX1 CEBPA STAT5A STAT5B CCND1 JUP SPI1 ARAF MYC RAF1 AKT2 AKT3 TCF7 AKT1 FCGR1A PIK3R2 GLI1 CEBPE RUNX1T1 ZBTB16 BRAF NFKB1 GRB2 ITGAM PIK3CD RARA BCL2A1 RPS6KB2 PIK3CB HRAS SOS2 LEF1 PML DUSP6 PIK3CA TCF7L2 STAT3 TCF7L1 PER2 PIK3R3 BAD CCNA1 SOS1 PIK3R1 NRAS CHUK EIF4EBP1 RELA MAP2K2;MAP2K1 IKBKB PPARD CSF2 MAPK1 IKBKG MAPK3 IL3 KRAS MTOR PIM1 PIM2 KIT RPS6KB1 CD14 CSF1R FLT3 CCNA2-1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260710%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260710%WP5178%HOMO SAPIENS Disorders of fructose metabolism ALDH1A1 PGM1 TPI1 G6PC1 GPI GLYCTK SLC5A1-1 PFKL ALDOB SORD KHK SLC2A2 FBP1 HK1 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260710%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production TDO2 NMRK2 QPRT AADAT HAAO KYNU AFMID NAMPT KMO NMNAT3 NMNAT1 NMNAT2 NADSYN1 NMRK1 NAPRT IDO1 G13 SIGNALING%WIKIPATHWAYS_20260710%WP524%HOMO SAPIENS G13 signaling PIK3CD RAC1 PIK3CB CFL1 IQGAP1 ARHGDIG PIK3CA ROCK1 ROCK2 WAS IQGAP2 MAP3K4 WASL PAK3 CDC42 MYL1 PKN1 MAPK10 TNK2 GNA13 RPS6KB1 PPP1CB ARHGEF1 PIK3R2 PIP4K2A RHOA CALM1 PFN1 RTKN SH3RF1 CFL2 LIMK1 ARHGDIB RHPN2 MYBPH CIT CYFIP1 DIAPH1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260710%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CLSTN1 STXBP2 CHL1 EPB41L1 EPB41L2 CDH2 NCDN NEO1 EFNA5 CLASP1 MAPK9 NTNG1 KCNJ6 CADM3 APLP2 CASK DAB1 SNW1 TERF2IP PLCB4 ANK3 CADM1 KCNMA1 GRIK2 KCNQ2 GRIN2B GRIN1 RAP1GAP CSN3 MAPK4 GABRG3;GABRG2 STX2 CAMK2G AGRN CAV2 ATP2B1 EPB41 PRKCZ GABBR2 GPHN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260710%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling GRIA1 GRIA2 CFL1 STAT5A GRIA3 STAT5B PTPN11 RPS6 GABRB3 RAF1 SQSTM1 CDK5 FRS2 RPS6KA3 SHC2 CNR1 CAMK2A PLCG1 GSK3B RPS6KA1 MAP3K2 MEF2A RAC1 CDH2 RASGRF1 RPS6KA5 STAT3 ADAM17 PRKAA1 CREB1 PRKAA2 DPYSL2 FRS3 DOK5 PIK3R1 RAB3A SIRPA;SIRPB1;SIRPG KCNN2 EIF4EBP1 DOCK3 YBX1 NTRK2 PRKCD PTPRF RELA BDNF RHOG KCNA3 GRIN2B IGF2BP1 MAPK1 SH2B2 GRIN1 SH2B1 KIDINS220 MAPK3 MARCKS MTOR RPS6KB1 CAMK4 EIF2S2 CAMK1 CSNK2A1;CSNK2A3 ELK1 SORT1 NTF3 STAT1 TRAF6 CYFIP1 MAPK8 TIAM1 EIF4E NTRK1 SHC4 PTK2B JUN RANBP9 MAPK14 IRS1 DLG1 NSF NGFR PPP2CB;PPP2CA LINGO1 EEF2 KSR1 AKT1 FOXO3 SHC3 CASP3 TSC2 PIK3R2 RAP1A SYN1 MAP2K5 NFKB1 GRB2 JAK2 MEF2C EIF2S1 CDKL5 HRAS VAV3 PDPK1 MAPK9 NTRK3 VAV2 ACACB NFATC4 MAP3K1 CDK5R1 BAD APC CHUK SRC MAPK7 MAP2K2;MAP2K1 IKBKB IKBKG CDC42 MAPK10 NCAM1 NCK2 FYN SHC1-1 NCK1 CRTC1 NCF1 NCF2 RACK1 GRIP1 IRS2 CTNNB1 NFKBIA NGF MAPT DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260710%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets CSF1 STAT3 ID2-1 TPO SPI1 TCF4 IRF4 IRF8 CSF2 IKZF1 RUNX2 FLT3LG BATF3 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP9 HDAC3 STAT6 PARP1 SKP1 STAT3 RBX1 DTX3L CUL1 HDAC2 BTRC STAT1 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAG1 PRKAG2 GJA3 PRKAG3 PRKAB2 TJP2 GJA8 PRKAB1 FMO5 BCL9 PRKAA1 PRKAA2 GJA5 AFDN F11R AMELY;AMELX ACP6 OCLN-1 KIRREL1 CHD1L TJP1 PYGO2 TJP3 GJA1 PYGO1 CTNNB1 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260710%WP5166%HOMO SAPIENS Glyoxylate metabolism PRODH2 LDHA ALDH4A1 GRHPR GOT2-1 DAO SLC26A1 PXMP2 HAO1 HOGA1 AGXT NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260710%WP438%HOMO SAPIENS Non homologous end joining XRCC6 WRN XRCC4 XRCC5 PRKDC POLM LIG4 POLL NHEJ1 DCLRE1C RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260710%WP2290%HOMO SAPIENS RalA downstream regulated genes RAC1 KRAS NRAS EXOC8 HRAS RALBP1-1 YBX3 RALA-1 CDC42 EXOC2 RAC3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260710%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling EPHX1 ABCG2 MAPK8 KEAP1 HMOX1 JUN MAPK14 MAPK12 MAPK13 MAPK11 GSTP1 ABCC6 ABCC3 ABCC4 NQO2 NFE2L2 SRXN1 NQO1 ABCC2 FOS GCLC GCLM CES1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 PIN1 TANK MAPK8 TNF IFNB1-4 MAPK14 MAPK12 TBKBP1 MAPK13 MAPK11 IFIH1 IFNE MAP3K7 IFNK TRADD CASP8 TRAF3 RIPK1 FADD CXCL8 OTUD5 NFKB1 CXCL12 CYLD ATG12-1 IKBKE MAPK9 MAP3K1 SNW1 ATG5 CHUK RELA IKBKB IKBKG CXCL10 ISG15 MAVS MAPK10 TBK1 CASP10 DDX58 NLRX1 IRF3 NFKBIB AZI2 DDX17 TRAF2 DHX58 SIKE1 NFKBIA RNF125 TRIM25 IFNG TKFC TRAF6 DDX3X-1 STING1 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260710%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes PLPP6 HMGCR IDI1 MVK MSMO1 SREBF1 HSD17B7 ACAT2 TM7SF2 HMGCS1-1 EBP NSDHL PMVK SC5D HMGCS2 CYP46A1 LBR ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 ACSL1 ELOVL4 NR1H2 ELOVL3 NR1H3 ACSL3 DHCR24 LSS CH25H CYP27A1 SCD MVD ABCG1 FADS2 ABCA1 ELOVL5 ELOVL2 IDI2 CYP7A1 CYP51A1 ROTENONE METABOLISM%WIKIPATHWAYS_20260710%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2C9;CYP2C19 IL2 SIGNALING%WIKIPATHWAYS_20260710%WP49%HOMO SAPIENS IL2 signaling CBL IL2RG NMI SOCS3 RPS6KB2 HRAS CISH PTK2B STAT5A STAT5B PTPN11 STAT3 IL2RA IL2RB RPS6 IL2 PIK3R1 SOS1 MAP2K2;MAP2K1 RAF1 MAPK1 SYK MAPK3 AKT1 FOXO3 FYN RPS6KB1 SHC1-1 JAK1 GRB2 CRKL LCK JAK3 STAT1 GAB2 MAPT INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260710%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway LOXL4 BMP2 FN1 DDR1 CDC37 PKD1 TGFB1 ANXA5 ECSIT SIRT1 FGF7 SUV39H1 IGFBP7 COL2A1 NFE2L2 NQO1 EXOC6 NRF1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260710%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 IKBKE TLR7 EIF2AK2 JUN OAS3 MAPK14 IFNAR2 IFIH1 STAT2 CHUK OAS1 IKBKB MAP3K7 IFNAR1 IKBKG MAVS TRAF3 RIPK1 MYD88 JAK1 TBK1 DDX58 NFKB1 TICAM1 IRF3 FOS NFKBIA STAT1 IRF9 TYK2 TRAF6 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies EGFR ITGB7 TGM2 ITGA4 TNF F2RL1 IL15 GZMH;GZMB-1 IL21 CD4 IL2 DHODH IFNG HEART DEVELOPMENT%WIKIPATHWAYS_20260710%WP1591%HOMO SAPIENS Heart development HAND1 GATA6 NFATC3 NOTCH1 SRF TBX20 SMYD1 IRX4 GATA4 TBX5 NKX2-5 TBX2 PTPN11 HAND2 NFATC4 SMAD1 TBX1 NFATC1 FGF8 MAPK1 BMP4 SHH FGF10 BMP2 BHLHE40 BMPR1A ISL1 BMPR2 FOXC2 FOXH1 FOXC1 NFATC2 SMAD4 HEY1 VEGFB BMP10 PITX2 VEGFC HEY2 ERBB3 MEF2C CTNNB1 FOXA2 VEGFA KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260710%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCA2 SMARCA4 PAXIP1 ARID1A RXRA ARID1B SMARCD1 KMT2C SMARCD2 SMARCD3 H3-3A DPY30 EHMT1 ASH2L RBBP5 WDR5 NCOA6 ASXL1 BAP1 KDM6A PAGR1 SMARCB1 ACTL6A SMARCC1 SMARCC2 MBD5 ACTL6B NR1I3 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260710%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PPP3CA RAC1 PPP3CB MAPK8 EDN1 CTF1 CAMK2D LIFR GATA4 JUN PRKCB STAT3 AGT MYEF2 MAPK14 NFATC4 RHOA MAPK11 MAP2K3 CALM1 FOS MAPK1 IL6ST PRKCE CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260710%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IRF7 POLR2E POLR2F POLR2H POLR3B POLR3D IFNB1-4 POLR3H ADAR POLR3K CGAS IL6 ZBP1 AIM2 TREX1 POLR2L RIPK3 IL18 TRADD CASP8 RIPK1 CCL4L2;CCL4L1;CCL4 FADD IL33 IL1B NFKB1 POLR3GL CYLD PYCARD POLR3A ATG12-1 POLR3C POLR3F POLR3G IKBKE ATG5 CHUK POLR3E RELA IKBKB CCL5 IKBKG CXCL10 ISG15 MAVS TBK1 CASP10 CASP1 DDX58 NLRX1 POLR1C POLR1D IRF3 NFKBIB NFKBIA RNF125 TRIM25 STING1 MRNA PROCESSING%WIKIPATHWAYS_20260710%WP411%HOMO SAPIENS mRNA processing DICER1 SRP54 HNRNPL SRSF10 SRSF9 RNMT PPM1G TMED10 SUPT5H SRPK1 PCBP2 PRMT1 SF3B4 NONO SMC1A CD2BP2 YBX1 RBM39 HNRNPU METTL3 SRPK2 POLR2A DHX9 SNRPN HNRNPD U2AF1L5;U2AF1 HNRNPR EFTUD2 SNRPD2 SNRPD1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 XRN2 SRSF2 SRSF3 SREK1 SRSF5 SNRPF SRSF6 SRSF7 SNRPA SNRPB DHX8 CSTF3 DDX1 CSTF2 SNU13 PRPF8 DHX38 SNRPE-2 CPSF4 CPSF1 FUS CPSF3 CLK4 CLK3 LSM2 CLK2 SFPQ-1 CLK1 HNRNPM LSM7 HNRNPK RNPS1 CLASRP HNRNPC SUGP2 SUGP1 CELF1 CELF2 CELF4 PTBP1 SNRNP70 DHX15 DHX16 RBM5 CPSF2-1 RBM17 PRMT2 NCBP1 PRPF40A PTBP2 PRPF18 HNRNPH1 SNRPA1 HNRNPH2 DNAJC8 HNRNPA1-1 SF3B5 SF3B2 SF3B3 SFSWAP SRSF1 DDX20 CSTF2T NXF1 U2AF2 SNRPB2 TRA2B SPOP RNGTT SNRPG-2 SF3B1 SF3A3 SF3A1 SRSF4-1 SF3A2 HNRNPAB NUDT21 NCBP2-1 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 RBMX MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260710%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation RAC1 TIAM1 CLASP1 NTRK1 NTRK3 STAT3 AURKB DPYSL2 GNAQ APC MAPKAPK2 ROCK1 SRC STMN1 MARK2 NTRK2 PAK1 RHO PRKACA-1 MAP1B TRIO CDC42 F2RL2 AKT1 PTPRA DVL1 ABL1 CDK1 CAMK4 PRKCA WNT3A EPHB2 TESK2 MAPRE1-1 SPRED1 PARD6A TPPP CFL2 MARK1 LIMK1 CLIP1 TAOK1 KIF2C GSK3B MAPT PHLDB2 PTEN DIAPH1 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PRCC CBL C8orf34 STRN MAPK8 PTPN11 JUN KDR BUB1B-PAK6;PAK6 ARAF ALK RAF1 AKT2 AKT3 AKT1 PIK3R2 RAP1B RAP1A HGF BRAF PLCG1 PTK2 MET GRB2 CRKL VEGFA PIK3CD RAC1 PIK3CB HRAS RPL11 SOS2 PIK3CA STAT3 RAPGEF1 GAB1 PAK5 PIK3R3 BAD SOS1 PIK3R1 CRK NRAS SRC MAP2K2;MAP2K1 PAK1 MAPK1 PAK3 PAK2 CDC42 MAPK3 PAK4 ETS1 KRAS CDKN1A TFE3 ELOA JAK3 INSL3 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260710%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 CETP USF1 APOA2 APOA1 LDLR LPL LCAT APOA4 LIPC PLTP GPIHBP1 PCSK9 GHR APOB EPHX2 LDLRAP1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260710%WP1584%HOMO SAPIENS Type II diabetes mellitus PIK3R5 MTOR MAPK8 KCNJ11 PDX1 TNF PHKA2 SOCS4 ADIPOQ GK INS;INS-IGF2 CACNA1A INSR IRS1 SLC2A2 PRKCZ IKBKB SLC2A4 MAPK1 MAFA SURF1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK8 MAP2K7 MAPK9 MAP3K21 MAP2K6 PARP1 ATF4 MAP3K1 MAPK14 MAPK12 TNKS MAPK13 MAPK11 ARAF MAP2K2;MAP2K1 MAP3K7 RAF1 MAPK1 MAP3K9 MAPK3 DUSP1 PARP14 MAPK10 MAP3K8 MAP3K10 MAP3K11 MAP3K12 BRAF MAP3K5 MAP2K3 MAP2K4 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260710%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH IGF1 SST GNRH1 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260710%WP3601%HOMO SAPIENS Lipid particles composition CETP APOA2 APOA1 LDLR APOC3 LPL LCAT APOE APOB APOC2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260710%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260710%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC6A6 SLC15A4 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260710%WP5601%HOMO SAPIENS Caffeine in blood vessels ADCY6 ADCY5 ADCY4 ADCY2 RYR2 PDE3B GUCY1A2 RYR3 GUCY1A1 ADRA1D PPP1R12A PDE3A ADCY9 PPP1R12C CALM3;CALM1 ADRA1B ADRA1A CALM2 ADORA2B PPP1CB NOS3 PDE4B PDE4A ADORA2A ADORA3 CALM1 ADCY3 ADCY1 ADCY8 ADCY7 PDE4D-1 MYLK MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260710%WP2005%HOMO SAPIENS miR targeted genes in muscle cell STRN GRIA2 CPOX MOV10 ARF4-1 SDCBP CCND1 PKM CDIPT PDE3A CPNE8 VEZT LAMC1 SRPRB-1 PWP1 C1QBP COL3A1 CHORDC1 RAVER2 CDK5RAP1 ANKFY1 CIAO2A UAP1 SEC62 CDK5RAP3 TMEM41B-1 GNPNAT1 MBNL1 IFRD1 FNDC3B FNDC3A GFPT1 SCAMP1 DHX40 PGM1 CARHSP1 METTL7A-1 HMOX1 AP3D1 WDR82 FAR1 FADS2 SLC38A5 TM6SF1 TMEM87A P4HA2 HACD3 UBE2J1 MRPL20 SPCS3 COMMD9 GRPEL2 ATP6V1C1 ATP6V0A1 SNX6 NCEH1 TRAM1 GFM1 MAGT1 PSAT1 MRC2 PANX1 SFXN1 COIL HYAL3 TMED3 GNL3L-1 CTSC FGF2 MRPS24 AGO3;AGO1 AP3B1 GAK SLC7A6 CDCP1 VSNL1 CSDE1 PTPRJ FRG1 SRF PXDN PAFAH1B2 BRPF3-1 AMIGO2 PTMA FSTL1 NAPG PGRMC1 ATAD3A;ATAD3B RTN4 PPP1R7 MPZL1 CA12 SPRYD4 PTPA TTC9C ARCN1 WDR11 HDAC4 TPPP3 NFIA SNX15 NUCB1 TBCA LAMTOR3 LAMTOR5 ACAA2 TUSC2 LTN1 ARID4B LCLAT1 ABHD10 RHEB SPARC POGLUT3 KPNA3 RARS1 KRAS NCOA3 STX7 UBE4A CDKAL1 RAB30 DMTF1 SYPL1 RAB34 WDFY1 RB1 MATR3 GEMIN7 CDKN1A PPIB RAI14 CBFB KCNQ1 SLC1A4 ADIPOR2 TGFBR2 CORO1C SLC9A3R2 PRKCI CAMTA1 RAB6A SLC38A2 CD164 THBS1 SLC4A10 CHMP2A ERBB3 SNAP23 DOCK7 TNFAIP2 CDK6 LMNB2 TMEM109 ACP2 SCYL1 POLR2C HSDL1 EGFR ATRX SSNA1 RCN2 RBMS1 MTPN LUZP1 EIF4E NUFIP2 NXN CSNK1D UHRF1 MCL1 HSD17B12 DNAJB1 ADAR CAND1 TP53INP1 SH3BP4 MAPK14 LRRC8A MAPK12 ZNF622 PDLIM5 SLC12A2 SLC25A24 IRS1 GALNT7 SLC12A4 MYLIP BCL2 MYO10 SLC4A7 ATP6V0E2;ATP6V0E1 FMNL2 SLC25A32 NAA15 ARHGDIA BET1 WNT5A LAMC2 GNA13 CHD1 ANP32B SYNE2 MET CDKN1B COL1A1 COL1A2 CNOT9 DOCK5 BACH1 ERBB2 SNAP29 ESR1 G6PD CLDN1 ANPEP CEBPB YWHAQ MTRR ATP2A2 GJA1 TYMS NOTCH2 DNMT3A CACNA2D1 CCNG1 NCL-1 CCN1 MTHFD2 SLC7A11 CTNNB1 DSG2 SYNE1 NRP1 ACVR1B HES1 GALNT1 PISD ZEB1 SLC25A13 HIPK3 IGF2R LRP1 TMEM43 NELFCD ELMOD2 CSRP1 SRSF10 PICALM SRSF9 TXN2 TXNRD1 CYP1B1 TPM2 TMED10 GPD2 RAD23B ANAPC1 TDG POLE4 USP1 GSTM4 CXCL12 ERG CUL4B ABCG2 PLK1 ARID1A VPS39 TMED2-1 PTPRF RHOG CALCOCO2 IGF2BP1 AXL PKN2 PODXL EHMT2 NEDD4 E2F3 MYO1E ATG9A SPTLC1 PDLIM7 POLA2 RAB27B IPO4 E2F1 CYP51A1 RDH10 LPL EHMT1 ASH2L EZH2 SLC38A1 NT5E SHOC2 RFT1 CSF1 POLD2 ITGB4 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CLOCK PPP3CA TMED7 NOTCH1 CAPG ITGA2 DHX15 PPIF TPM4 PTBP2 TPM3 SEC23A MAPK7 TPM1 SEC24A KIT GPAM PDCD4 SLC25A1 NF2 BACE1 SH3BGRL3 PHLDB2 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260710%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement PRKCQ ITGAV MYL2 ITPR1 TJP1 VCL PXN JUN CREB1 PTK2 PLCG1 ACTN1 MAPK1 ITGB3 LPP MFAP5 MAPK3 MYLK T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260710%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PGF ARG1 IL6 FAS IDO1 PDGFA NT5E SHH VSIR B2M VTCN1 CCL17 CD276 FAP ENTPD1 LGALS3 TNFSF4 LGALS1 CCL22 TNFSF9 PDGFB IL13 CD40 VEGFB CD28 LGALS9C;LGALS9;LGALS9B VEGFC VEGFD TGFB2 CXCL12 TGFB3 VEGFA IL10 CD86 TGFB1 CD80 PVR IL4 CTLA4 TIGIT CD274 CXCR4 PDCD1LG2 PDCD1 ICOS TNFRSF4 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PDGFD VDR PDGFC FASLG CD40LG TNFRSF9 CD226 HAVCR2 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260710%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 PC ASL ASPA GPT ABAT DARS1 GAD2 GOT2-1 GOT1-1 AGXT ASS1 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260710%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260710%WP2253%HOMO SAPIENS Pilocytic astrocytoma NF1 BRAF KRAS SOS1 NRAS HRAS GRB2 PTPN11 RAF1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260710%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCB11 CYP8B1 HSD17B4 FABP6 SLC10A2 SCP2 ABCB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCD3 CYP27A1 HSD3B7 SLC51A BAAT SLC51B CYP7B1 AMACR ACOX2 SLC27A5 AKR1D1 ABCC3 CYP7A1 ABCC4 SLC27A2 ABCC2 ATP8B1 SLC10A1 ABCB4 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260710%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation CASP1 IL1B NFKB1 PYCARD CTSB TLR4 NOX1 THERMOGENESIS%WIKIPATHWAYS_20260710%WP4321%HOMO SAPIENS Thermogenesis ADCY6 ADCY5 ACSL6 ACSL5 KLB KDM1A ADCY10 RPS6 TSC1 SIRT6 ZNF516 MGLL KDM3B FRS2 RPS6KA3 CREB3 RPS6KA6 CREB3L3 CREB3L4 CREB3L1 RPS6KA2 CREB3L2 LIPE CREB5 CPT1B CNR1 SMARCB1 SMARCC1 SMARCC2 RPTOR RPS6KA1 PRKAG1 PRKAG2 ARID1A RPS6KB2 ARID1B PRKAG3 SMARCD1 SMARCD2 PRKAB2 SMARCD3 PRKAB1 PRKAA1 CREB1 PRKAA2 NRAS GCG RHEB PPARGC1A KRAS MTOR RPS6KB1 ATF2 MLST8 PNPLA2 MAP3K5 MAP2K3 ACTL6A AKT1S1 MAPK14 MAPK12 FGFR1 MAPK13 MAPK11 CPT1A ACSL1 ACSL4 ACSL3 TSC2 DPF1 BMP8A;BMP8B DPF3 CPT1C KDM3A SLC25A29 SMARCE1 GRB2 PRKG2 ACTL6B SMARCA2 SMARCA4 HRAS ADCY4 ADCY2 SOS2 PRKACB-1 ADRB3 PLIN1 ADCY9 SOS1 BMP8B GNAS-1 PRDM16 UCP1 PRKACA-1 ACTG1 FGF21 NPR1 PRKG1 CPT2 SLC25A20 ACTB-1 ADCY3 ADCY1 ADCY8 ADCY7 PPARG GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260710%WP4823%HOMO SAPIENS Genes controlling nephrogenesis GDNF FGFR2 ETV4 PDGFRB ITGA3 SLIT2 KDR ITGA8 CD36 PAX2 ITGB1 CD2AP LMX1B FGF8 CXCR4 SHH LAMB2 MAFB TCF21 NCK2 KIRREL1 NPHS1 EMX2 NPHS2 FOXD1 WT1 RET NCK1 NOTCH2 SIX1 WNT4 FOXC2 FOXC1 HOXD11 GLI3 PDGFB HOXA11 ROBO2 LHX1 MAGI2 EYA1 CXCL12 ILK CTNNB1 VEGFA HNF1B BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260710%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome PRKAG1 PRKAG2 MAPK8 PRKAG3 MAPK9 PRKAB2 PRKAB1 PRKAA1 ACACB MAPK14 PRKAA2 MAPK12 G6PC2 MAPK13 MAPK11 G6PC3 ACLY MAPK1 MAPK3 ACACA MAPK10 PCK2 G6PC1 SLC27A2 CRP FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260710%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor FN1 MAPK10 MAPK8 SMAD2;SMAD3 MAPK9 TGFB1 STAT3 CCN2 ENPP2 TGFB2 RHO TGFB3 ACTA2 COL1A1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism TBXAS1 PTGS2-2 PTGS1 EPHX2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260710%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection RUNX1 ELOB ELOC-1 UBB;UBC CBFB CUL5 RBX1 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD6 SMAD7 FKBP1A SKI BAMBI TNF CREBBP JUN EP300 SMAD2;SMAD3 WNT1 SMAD4 NFKB1 RUNX2 ITGB6 HRAS LEF1 MAPK9 TGFB1 STAT3 SMAD1 SMAD9 SMAD5 BMP4 MAPK3 ZFYVE9 SERPINE1 TGFBR1-1 TGIF1-1 JAK1 LEFTY2;LEFTY1 FST FOXH1 TFE3 NOG RUNX3 TGFBR2 TGFBR3 ZEB2 ENG LTBP1 THBS1 SPP1 ZNF423 CTNNB1 FOS SKIL EGF IFNG STAT1 LIF INHBA GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260710%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways PCNA GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CETN2 XPA XPC PARP2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 CHEK1 RPA2 RAD23A WDR48 GTF2H1 ERCC5;BIVM-ERCC5 GTF2H3 RAD23B GTF2H4 DDB2 RBX1 CUL4A DDB1 TDG POLE4 PRKDC CDK7 USP1 ERCC3 ERCC4 ERCC1 POLE2 SMUG1 RPA3 POLE3 ERCC2 ERCC8 ERCC6 MNAT1 CUL4B BRCA1 POLK PARP1 ATR XRCC6 WRN XRCC4 XRCC5 POLM LIG4 POLL MSH6 NHEJ1 DCLRE1C EXO1 MSH2 FANCD2 FAN1 MRE11 RPA1 BRCA2 RAP1A RAD54B RAD52 POLD3 POLD4 RAD50 RAD51 POLD1 POLD2 NBN MPG FAAP100 ATM REV1 LIG3 NEIL3 NEIL2 MSH3 CENPS-CORT;CORT;CENPS BRIP1 NTHL1 FANCI FANCM FANCL FANCA XRCC1 FANCC FANCE PALB2 FANCG FANCF FEN1 OGG1 HMGB1-1 POLB REV3L POLI POLH RAD51C PNKP FAAP24 UNG LOC105377022;FANCB PMS2 MUTYH MBD4 CENPX MGMT APEX2 MLH1 TERF2 APEX1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260710%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 ASAH1 KDSR SPHK2 SGPP2 SGPP1 SPHK1 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260710%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation AJUBA CTNNA1 CCND1 CDH1 KDR PPP1R12A IGF1R RBX1 CUL4A DDB1 FGFR4 CDH2 CD44 CDH18 PAK5 NRAS NTRK2 PAK1 CXCL10 KRAS PDGFRA FGFR2 EGFR NTRK1 TEK FGFR1 BUB1B-PAK6;PAK6 ITGA2B MYC NGFR ITGB3 PPP1CA PPP1CB PPP1CC FLT1 CDH5 CCN2 INSR PTK2 ITGA10 ITGA11 MET ITGAM ITGB5 ITGB4 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 HRAS ITGA4 PDGFRB ITGA3 PRKACB-1 ITGA2 ITGA1 ITGAD ITGA8 ITGA7 ITGA6 PLCB4 ITGA5 ITGB1 FLT4 CDH9 CDH8 CDH7 ITGA9 CDH6 CDH4 CDH3 TEAD1 PRKACA-1 TEAD2 DCAF1 TEAD3 LIN28B TEAD4 PAK3 FOXM1 PAK2 MST1 VGLL4 LATS1 PAK4 PPP1R14A LATS2 PRKAR1B PRKAR1A CDH10 CDH11 KIT CDH12 CDH13 CDH15 CSF1R CDH16 CDH17 FLT3 CDH19 EPHA2 STK3 YAP1-1 CDH20 PRKAR2B PRKAR2A SAV1 CDH22 CDH24 WWTR1 NF2 FGFR3 CTNNB1 AMOT STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP496%HOMO SAPIENS Steroid biosynthesis F13B CPN1 HSD3B1;HSD3B2 CYP17A1 HSD17B3 HSD17B7 HSD17B4 HSD17B1 HSD17B2 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260710%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs TPI1 PGAM1 GK ALDOB GPD1 ALDOA LOC100509620;LOC112267859;AQP7 FBP1 MGLL AQP9 SDS PGK1 AKR1A1 PCK1 PKLR GRHPR LIPE GPD2 G6PC1 AGXT PNPLA2 GPI GLYCTK PFKL PC KHK ENO1 HK1 GAPDH-1 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260710%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 CETP VLDLR APOA2 APOA1 LDLR LPL LCAT APOA4 LIPC LRP1 PLTP SCARB1 APOE DNA MISMATCH REPAIR%WIKIPATHWAYS_20260710%WP531%HOMO SAPIENS DNA mismatch repair POLE RFC5 RFC3 RFC4 LIG1 PCNA RFC1 RFC2 RPA2 RPA1 EXO1 POLD3 POLD4 POLD1 POLE4 POLD2 PMS2 MSH6 POLE2 RPA3 POLE3 MLH1 MSH2 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome GRIA1 HFE DYNLT2B STAT5A TF STAT5B JUN TFRC SLC40A1 DLG1 HAMP MYC PCYT1A FBXW7 RNF8 HIF1A ADAM10 CASP7 SLC51A SLC51B PXN UBE2N NRROS DYNLRB2 DYNLRB1 DYNC2I2 DYNC2I1 TGFB1 SIRT1 PIK3R3 DYNLT1 NCBP1 PAK2 CEP19 PIGZ SENP5 UBXN7 MAD2L1BP-1 SMCO1 H2BC21 DYNC2H1 FNDC8 PIGM MYCBP2 RNF168-1 FBXO45 DYNC2LI1 BRINP1 TM4SF19 RABL2A;RABL2B NCBP2-1 CEP350 MCRS1 PIGX-1 WDR53 ZNF76 MELTF CEP43 NF2 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260710%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 ACOT2;ACOT1 FADS2 FADS1 ELOVL5 ELOVL2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP4970%HOMO SAPIENS Galanin receptor pathway BCL2L11 CDKN1A ADIPOQ POMC CREB1 YAP1-1 INS;INS-IGF2 IL6 CDKN1C CDKN1B SLC2A4 FOS VEGFA VAMP2 CRP PPARG CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260710%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CRYAB TRIM55 SRF NBR1 NUP62 PRKACB-1 ADRB1 ADRB2 MAP2K2;MAP2K1 FHL2 PRKACA-1 TRIM63 RAF1 MAPK1 MDM2-2 NPR1 PRKAR1A PRKCA PLCZ1 CAMK2A GUCY1B1 FHL1 GUCD1 CSRP3 ANKRD1 ANKRD2 MYPN ANKRD23 PRKG2 TTN-1 TCAP SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260710%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis DLL1 NOTCH1 MESP2 DLL3 EPHA4 RIPPLY2 HES7 TBX6 LFNG SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260710%WP615%HOMO SAPIENS Senescence and autophagy in cancer LAMP1 FN1 SLC39A2 SLC39A1 SLC39A3 PCNA SH3GLB1 UVRAG ING1 ING2 SERPINB2 RNASEL IFI16 CREG1 MAP1LC3B2;MAP1LC3B-1 RSL1D1 PLAT IGFBP7 COL3A1 ULK1 RAF1 IGF1R IGFBP5 SQSTM1 CDC25B CXCL8 COL10A1 GSN CXCL2;CXCL3;CXCL1-1 GSK3B PTEN MAP1LC3A CD44 CCL3L1;CCL3L3;CCL3;CCL18 BMI1 IL6R IRF1 IL6ST MAPK1 VTN SPARC MTOR SERPINE1 FKBP8 RB1 ATG14 CDKN1A MLST8 MAP2K3 THBS1 E2F1 AKT1S1 IFNG INHBA TP53 IRF7 MMP14 IFNB1-4 JUN CDKN2A MAPK14 IL6 BCL2 PLAU MDM2-2 TNFSF15 GABARAPL2 GABARAP SMAD2;SMAD3 SLC39A4 SMAD4 BRAF RB1CC1 IL1B LAMP2 KMT2A ATG3 ATG10 IL24 CDKN1B ATG13 COL1A1 ATG12-1 BECN1 HRAS PIK3C3 MAP1LC3C AMBRA1 TGFB1 IRF5 ATG7 INS;INS-IGF2 ATG5 SRC IGF1 MAP2K2;MAP2K1 IL3 CEBPB CXCL14 BMP2 ATG16L1 IL1A IGFBP3 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260710%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DDX1 NBN DGCR8 DROSHA ATM MRE11 RAD50 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP4478%HOMO SAPIENS LTF danger signal response pathway TREM1 IRAK4 TNF CD14 MYD88 IFNB1-4 CXCL8 IL1A LTF TLR2 IRAK1 IL1B NFKB1 IL6 MAPK1 AGER TRAF6 TLR4 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260710%WP4298%HOMO SAPIENS Acute viral myocarditis SOCS1 TNF DMD BID CCND1 CD4 CAAP1 IL2 ENDOG CXADR NOD2 CD55 IL6 CHRAC1 ABL2 BNIP2 BCL2 BAX BCL2L1 EIF4G2 CCR5 AKT1 CASP9 EIF4G1 CYCS-1 CASP7 CASP8 CASP3 IL12B CAV1 MMP9 TICAM1 NFKB2 ITGB2 ILK PYCARD ITGAL CASP2 GSK3B RAC3 NOS1 EDN1 DAG1 IL10 PARP1 RASA1 TGFB1 CD80 STAT3 KRT8 TLR3 CREB1 IL12A SOS1 PIK3R1 SRC HLA-DMA CXCR4 MAPK1 MAPK3 ABL1 FYN PABPC1;PABPC3 MYH6 SGCD CCR3 JAK1 SGCA SGCB AIF1 CASP6 SGCG CD40LG CASP1 PTCRA DFFB DFFA ACTB-1 TLR5 IFNG STAT1 TLR4 LAMA2 CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260710%WP2029%HOMO SAPIENS Cell differentiation index TLX2 SRF TLX3 HDAC5 LEFTY2;LEFTY1 STAT3 TLX1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260710%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV FMR1 NLGN1 GRM1 CAMK2D SYNGAP1 ARC CAMK2B RYR2 NRXN2 YWHAG GRIN2A DLG1 NLGN3 HOMER1 NLGN2 NLGN4X;NLGN4Y GRIN2C GRIN2B DLG2 MAPK1 GRIN1 GRIN2D MAPK3 NRXN1;NRXN3;NRXN2 TJP1 CAMK2G CAMK2A NRXN3 SHANK1 STX1A DLGAP1 RPH3A CYFIP1 FOXP3 IN COVID 19%WIKIPATHWAYS_20260710%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL2RG STAT5A STAT5B CD86 CD80 STAT3 IL2RA IL2RB IL2 IL6 CD28 IL7R IL6R FOXP3 IL6ST GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260710%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260710%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle IDH3B SUCLG2 SUCLG1 ACO2 FH CS MDH2 DLD DLST IDH3A SDHC IDH2 SDHA IDH3G SDHD SUCLA2 SDHB OGDH LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260710%WP5146%HOMO SAPIENS Lung pathology of COVID 19 IL18 TNF TLR7 CCL13;CCL2 CXCL9 TLR8 TBK1 TLR3 CXCL11 DDX58 IL1B CGAS NFKB1 IFIH1 IL6 IRF3 CSF2 CXCL10 MAVS STING1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260710%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260710%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways ADCY6 PLCD1 ADCY5 CNN1 RAMP1 ATF4 GUCY1A1 LPAR1 IGFBP5 PRKD1 CRCP RXFP1 RXFP2 IGFBP4 CREB3 CNN2 CALD1 IGFBP6 GPR182 MAFF ADM RAMP2 RGS16 RAMP3 RLN2;RLN1 CORIN CAMK2A GUCA2B GUCA2A GRK6 PLCG1 ATF1 CALM1 DGKZ SFN NOS1 ITPR1 YWHAE YWHAB CAMK2B YWHAG CREB1 YWHAH GNAQ CALM3;CALM1 RGS14 PRKCD CALM2 MYL4 PRKCQ GSTO1 CRHR1 ATF2 GNG13 PRKCG PRKCH PRKCZ PLCG2 FOS ETS2 ATF5 JUN OXTR IL6 MYLK2 GNB2 GNB4 GNB3 GNB5 ATF6B GNG2 GNG5 GNG4 GNG8 PDE4B OXT-1 ACKR3-2 IL1B NFKB1 PDE4D-1 RGS4 RGS5 CRH RGS2 CALCA RGS3 ADCY4 ADCY2 RGS1 ARRB1 ARRB2 CAMK2D PRKACB-1 RGS9 RGS6 PRKCB RGS7 RYR1 RYR2 ACTC1;ACTG2 RYR3 PLCB3 ADCY9 ITPR2 ITPR3 GNAS-1 GRK5 GRK4 GNGT1 PKIB PRKACA-1 SP1 ACTA2 ACTG1 PRKCE PKIA GNB1 ACTA1 PKIG ATP2A3 PRKAR1B YWHAQ ATF3 PRKAR1A MYL2 RGS18 RGS17 ATP2A2 RGS19 SLC8A1 GJA1 RGS20 CAMK2G PRKCA NOS3 GABPB1 YWHAZ PRKAR2B GABPA PRKAR2A RGS11 IGFBP3 ACTB-1 RGS10 CACNB3 ADCY3 ADCY1 IGFBP1 IGFBP2 ADCY8 ADCY7 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260710%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 KEAP1 SLC7A5 NFE2L2 SLC7A11 ATF4 SLC1A5 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260710%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYB5A HSD17B3 CYP21A2 POR CYP19A1 H6PD SRD5A2 CYP11B1;CYP11B2 HSD11B1 HSD11B2 CYP11A1 CYP17A1 HSD3B1;HSD3B2 STAR SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260710%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A IL3 SIGNALING%WIKIPATHWAYS_20260710%WP286%HOMO SAPIENS IL3 signaling CBL MAPK8 STAT5A STAT5B PTPN11 JUN BCL2 BCL2L1 RAF1 AKT1 ENPP3 LYN PIK3R2 CXCL8 CD69 INPP5D GRB2 JAK2 CRKL PIK3CD HRAS CD86 TGFB1 STAT3 YWHAB RAPGEF1 BAD SOS1 PIK3R1 SRC MAP2K2;MAP2K1 HCK PRKACA-1 MAPK1 SYK VAV1 IL5RA MAPK3 IL3 YWHAQ PTPN6 FYN SHC1-1 CCR3 JAK1 CSF2RB FOS GAB2 IL3RA VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260710%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPL ALDH7A1 PDXK PNPO PLPBP ALPG;ALPP;ALPI-1 PIGV AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260710%WP1403%HOMO SAPIENS AMP activated protein kinase signaling TP53 CRTC2 ADIPOQ CAMKK1 TSC1 STK11 CPT1A ADRA1B ADRA1A AKT2 PFKFB3 EEF2 AKT1 EEF2K ACACA TSC2 PIK3R2 LIPE CPT1B CPT1C INSR GYS1 FASN SLC2A4 ADIPOR1 SLC2A4RG PIK3CG RPTOR PRKAG1 PIK3CD PRKAG2 HMGCR RPS6KB2 PIK3CB PIK3C3 PRKAG3 SREBF1 PRKAB2 PRKACB-1 PRKAB1 PIK3CA STRADB PRKAA1 ACACB CCNB1 PRKAA2 INS;INS-IGF2 PIK3R3 CCNA1 PIK3R1 PLCB1 EIF4EBP1 CAMKK2 STRADA HNF4A CAB39 PPARGC1B LEPR ELAVL1 LEP MTOR RPS6KB1 CDKN1A ADIPOR2 CCNA2-1 GYS2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260710%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition AKT1 SNAI2 FN1 CDH2 SMAD2;SMAD3 VIM CDH16 CDH1 TNC SMAD4 ID1 CDH6 MAPK1 AKT2 RUNX2 AKT3 MAPK3 SNAI1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260710%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption ADCY6 DYNC1I1 DYNC1I2 DYNC1LI2 RAB5A ARHGDIG PRKACB-1 DYNC1H1 CREB1 DYNC1LI1 ADCY9 NSF GNAS-1 AVP AQP4 PRKACA-1 DCTN6 ARHGDIA DCTN5 VAMP2 DCTN2 AVPR2 DCTN1 DCTN4 RAB11A RAB11B CREB3 CREB3L3 CREB3L4 DYNC2H1 CREB3L1 CREB3L2 CREB5 DYNC2LI1 RAB5B RAB5C ADCY3 ARHGDIB AQP2 AQP3 STX4 BASE EXCISION REPAIR%WIKIPATHWAYS_20260710%WP4752%HOMO SAPIENS Base excision repair APTX POLG2 XRCC1 TDP1 PCNA ADPRS NEIL1 PARP1 FEN1 OGG1 HMGB1-1 POLB PNKP POLG UNG MUTYH MBD4 PARP3 PARP2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 POLD3 POLD4 TDG POLD1 APEX1 POLD2 POLE4 PARP4 POLL MPG POLE2 SMUG1 LIG3 POLE3 NEIL3 NEIL2 NTHL1 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260710%WP2363%HOMO SAPIENS Gastric cancer network 2 AHCTF1 FANCI TP53 EGFR DSCC1 CHTF18 MTDH BRIX1 ATAD2 CACYBP FAM91A1 RNF144B UBE2T RAD17 CD48 S100A6 CEBPZ LBR SNURF MYC RFC3 PLAC8 RFC4 TOP2A OTUD5 COL9A1 COL9A3 UBE2C CTNNB1 LMNB2 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260710%WP2369%HOMO SAPIENS Histone modifications EZH1 KMT2D KMT2C SMYD1 H3-3A EHMT1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EED EZH2 SUV39H2 SUV39H1 KMT2E SETD4 SETD5 SETD7 SMYD2-1 SETD3 SETD2 SMYD5 SETD9 SETD6 KMT2B DOT1L PRDM2 KMT5B SMYD4 KMT5A SMYD3 EHMT2 NSD1 SETDB1 KMT5C SETD1B SETD1A SETMAR ASH1L SETBP1 AEBP2 H4C1 H4C6 H4-16 KMT2A SET-1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260710%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway DPM2 PIGS PIGU PIGM PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGQ PIGP PIGX-1 PIGW PIGC PIGB PIGA PIGK MPPE1 PIGL PIGV PIGG PIGF PIGH DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260710%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260710%WP5574%HOMO SAPIENS Oligodendrocyte development DUSP15 ZNF24 NKX6-1 ZNF488 LGI1 OPALIN HES5 ZBTB33 CNTN1 ID4 TCF7L2 ID2-1 MYRF CHD7 SMAD1 NFIA OLIG2 ASCL1 SOX10 SOX6 TMEM98 BMP4 SHH EGR2 CSPG4 BMP1 SOX9 SOX5 PRKCA MBP MYT1 PTPRZ1 WNT10A NFATC2 SOX11 SOX2 GLI2 ZEB2 SOX8 RELN NKX2-2 PDGFRA NKX2-6 MAG FGF2 OLIG1 CHD8 PTN NRF2 PATHWAY%WIKIPATHWAYS_20260710%WP2884%HOMO SAPIENS NRF2 pathway EGR1 SLC39A2 HSPA1A;HSPA1B KEAP1 SLC39A1 SLC6A19 SLC39A3 PGD SLC6A6 SLC6A8 SLC5A5 NQO1 SQSTM1 ME1 TXNRD1 HMOX1 TXN SOD3 GGT1 MGST3 MAFF NRG1 MGST2 PDGFB SLC5A1-1 NFE2L2 GSTM4 SLC2A1 GSTM3 SLC2A4 GSTA3;GSTA1 CES2 CES1 GSTA3;GSTA5;GSTA1;GSTA2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PPARD UGT1A1;UGT1A6 TGFA GSTT2B;GSTT2 FTL-1 ABCC5 TGFBR2 GSTP1 SRXN1 HSP90AA1 CYP2A13;CYP2A6;CYP2A7-1 GSR TXNRD3 HBEGF BLVRB GSTM1;GSTM2-1 SLC39A9 SLC39A6 SLC39A5 SLC39A7 DNAJB1 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC5A6 GSTA4 ALDH3A1 SLC5A8 SLC5A9 CES3 EPHA3 SLC5A2 SLC6A20 CES5A FGF13 SLC5A3 SLC5A4 PRDX1 HSP90AB1 SLC2A9 SLC6A5 SLC6A7 SLC6A9 SLC6A1 SLC2A6 SLC6A2 SLC2A7 SLC6A3 SLC2A8 SLC6A4 SLC2A11 SLC2A10 SLC2A13 MAFG SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A11 SLC5A12 SLC5A10 CBR3 SLC39A4 SLC5A7 HGF ABCC3 ABCC4 TGFB2 ABCC2 CBR1-1 RXRA FTH1 SLC39A8 TGFB1 SLC39A14 G6PD GCLC GCLM SLC2A12 EPHA2 PRDX6 PTGR1-1 SLC2A2 SLC2A5 SLC7A11 SLC6A13 AGER SLC6A11 SERPINA1 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260710%WP2249%HOMO SAPIENS Metastatic brain tumor TP53 E2F3 PIK3R1 MYC CDK6 CDC42 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260710%WP3927%HOMO SAPIENS BMP signaling in eyelid development FGFR2 EGFR NOTCH1 TGFA MAPK9 JUN SFRP1 FOXC2 FOXC1 MAP3K1 SMAD4 INHBB SMAD1 PITX2 SMAD5 DKK2 BMP4 SHH MAPK3 FGF10 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260710%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia TNFRSF12A TNF ACVR2A STAT3 EP300 MAPK11 IL6 IL6R CHUK RELA IGF1 IKBKB TRIM63 IGF1R PDK1 IKBKG REL CEBPB AKT1 FOXO3 MTOR SMAD2;SMAD3 IL1R1 JAK1 FBXO32 IL1A MLST8 SMAD4 IL1B NFKB1 NFKB2 RELB MSTN AKT1S1 NFKBIA TNFRSF1A RPTOR MAP1LC3A NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism ST3GAL4 NEU2 NAGA B4GALT4 B3GNT5 FUT2 FUT6;FUT5;FUT3 FUT1 B4GALT3 B4GALT1 FUCA1 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260710%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC5A1-1 GNAQ SLC2A2 GCG PCSK1 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5275%HOMO SAPIENS Ether lipid biosynthesis GAL3ST1 PEX3 FAR1 LPIN1 LPIN3 CEPT1 ARSA PEX16 GNPAT UGT8 PEDS1-UBE2V1;PEDS1 PEX19 AGPS LPCAT1 PEX1 PEX7 LPIN2 PEX5L DHRS7B ALDH3A2 AGMO DGKQ FAR2 ACAD10 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260710%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis WNT3A WNT7A PROX1 NEUROD1 CCND1 WNT3 FZD3 WNT5A NEUROG2 LRP6 FZD1 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260710%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism BCKDHA BCKDHB ACSF3 IVD ACADSB ALDH6A1 MMUT HSD17B10 AUH BCAT1 DBT MLYCD HMGCLL1 HIBCH BCAT2 ACAT1 MCCC2 PCCA MCCC1 PCCB DLD ECHS1 ACAD8 HIBADH NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260710%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK3 PLA2G4A TRADD MAPK8 TICAM1 CASP8 TNF FTL-1 RIPK1 PARP1 FADD TNFRSF1A DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260710%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family TOX IL17A HNF1A GATA3 TNF GFI1 BCL11B IL15 IL22 IL4 IL5 ID2-1 IL12A IL6 NFIL3 TSLP IL18 IL7 IL9 RORA AREG TBX21 IL25 IL33 IL12B ZBTB16 IL1B IL13 EOMES RORC AHR IL23A IFNG VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260710%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGB1 ITGB7 ITGA4 ITGA2 ITGB2 ICAM1 MADCAM1 SELPLG VCAM1 SELE INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260710%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition INSR IRS1 MTOR TBC1D4 RPS6KB1 SLC2A4 AKT2 RPS6 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260710%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness PRKCQ ITGAV JUN RYR3 CREB1 PTK2 PLCG1 ITPR3 TNNC1 MAPK1 ITGB3 MFAP5 MAPK3 SLEEP REGULATION%WIKIPATHWAYS_20260710%WP3591%HOMO SAPIENS Sleep regulation DLAT CRH NLGN1 HTR2A DRD1 DRD3 NPAS2 CACNA1I MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 ADA MTNR1B OXTR GRIN2A IL6 CST3 NPS PTGDR IL18 AHCY CHRNB2 PTGDS NPY2R ADORA2A OXT-1 TH DRD2 GHRH ADORA1 BTBD9 HCRTR2 HCRTR1 STAR GHRL FOS UTS2R SLC29A1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260710%WP4249%HOMO SAPIENS Hedgehog signaling CUL3 LRP2 ARRB1 ARRB2 PRKACB-1 CSNK1D CCND1 TPTEP2-CSNK1E;CSNK1E DHH CDON HHIP IHH CSNK1G1 GRK2 CSNK1A1 KIF3A EVC2 CSNK1G3 SMURF2 CCND2 PTCH2 BCL2 FBXL17 KIF7 EVC SPOPL PRKACA-1 GAS1 CSNK1G2 SHH GPR161 SMURF1 PTCH1 GRK3 SPOP BOC GLI1 GLI3 GLI2 SMO FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260710%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 CETP SEL1L APOA2 APOA1 LDLR LPL LCAT APOA4 APOA5 LMF1 LIPC APOC2 LRP1 PLTP GPIHBP1 ANGPTL3 ANGPTL8 ANGPTL4 HUNGER AND SATIETY%WIKIPATHWAYS_20260710%WP5445%HOMO SAPIENS Hunger and satiety LEP MC4R NPY PYY AGRP GCG GHRL POMC SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC3 PAXIP1 NBN BRCA1 ATM MDC1 MRE11 SMC1A RAD18 RAD21 RAD50 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260710%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling GRIA1 PHGDH GRIA2 DLAT SLC1A1 SOCS3 CFL1 SLC1A2 PSPH SLC1A3 TNF SLC1A6 STAT6 GRIA3 GRIA4 CAMKK1 IL10RB GRIK5 IFNGR1 GRIK3 GRIK4 IFNGR2 DLD GRIK1 GRIK2 GLS2 SHMT2 SHMT1 GRM2 GRM5 GRM4 GRM7 DISC1 TNFRSF1B GRM8 PDHA1 SLC38A5 CAMK2A IL12B IL13 PSAT1 CALM1 SLC2A1 FGF2 NOS1 GRM1 ARC STAT3 CAMK2B CREB1 GRIN2A IL6R BDNF CAMKK2 GRIN2C GRIN2B IL6ST MAPK1 GRIN1 GRIN2D GRIN3B GRIN3A MAPK3 TGFBR1-1 CAMK4 DAO JAK1 SLC1A4 TGFBR2 TGFBR3 PRKCG SLC38A2 FOS TNFRSF1A IFNG STAT1 LIF TRAF5 SMAD7 IL10RA LRRC8A CNTF IRS1 IL6 BCL2 SLC38A1 AKT1 SLC6A9 PPP1CA SMAD2;SMAD3 SLC17A6 SLC17A7 PPP1CB IL1R1 PPP1CC SMAD4 INSR IL1B NFKB1 NFKB2 TGFB2 TGFB3 CAMK2D IL10 PRKCB TGFB1 IL4 IL12A PLCB3 PLCB4 PLCB1 PLCB2 IGF1 PRKACA-1 NSMF SLC38A3 TRPM4 SLC7A10 SRR LRRC8C LRRC8D IL13RA1 LRRC8B LRRC8E CAMK2G PRKCA IL1A GOT1-1 IL1R2 GFAP GLS GLUL ADCY3 ADCY1 IL4R NGF ADCY8 LTA INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260710%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260710%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G4E TP53 ALOX5 HRAS PLA2G1B PLA2G7 SLCO2A1 PLA2G3 PLA2G10;LOC100652777 PLA2G2D PLA2G5 CDKN1A PLA2G6 PLA2G4A PTGS2-2 PLA2G12A PLA2G4F PLA2G12B PLA2G4D NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260710%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG16L1 BECN1 ATG9B ATG4A SH3GLB1 UVRAG TSC2 AMBRA1 VMP1 ATG14 TSC1 INS;INS-IGF2 ATG7 INSR ATG5 ULK2 BCL2 ATG3 CHAF1A ATG10 ULK1 ATG12-1 MAP1LC3A INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260710%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RRAS2 KRAS MRAS HRAS RAB5A PDCD6IP RAB5B BRAF RAB27A HGS RAB5C NRAS ARAF HNRNPH1 RAF1 RRAS MAPK1 MAPK3 CORI CYCLE%WIKIPATHWAYS_20260710%WP1946%HOMO SAPIENS Cori cycle LDHA PGK1 TPI1 TALDO1 PGAM1 GPI INS;INS-IGF2 ALDOA SLC2A2 GPT G6PD SLC2A1 SLC2A4 PFKP HK1 GAPDH-1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260710%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways EBP ACOT2;ACOT1 SCP2 CYP27A1 ACOT9 DHCR7 BAAT AMACR ACOX2 THEM5 SLC27A5 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 ACOT6 ACOT4 HSD11B1 HSD11B2 NPC1-1 CYP7A1 NPC2 SLC27A2 DBP EPHX2 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260710%WP5399%HOMO SAPIENS NPHP1 deletion syndrome INVS NPHP1 FLNA RPGRIP1L BCAR1 PTK2B FLNB FLNC MAPK1 MAPK3 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260710%WP4758%HOMO SAPIENS Nephrotic syndrome SCARB2 SMARCAL1 PTPRO CUBN LMNA PLCE1 SYNPO ITGA3 TRPC6 CTLA4 ACTN4 PAX2 CD2AP CYP11B1;CYP11B2 INF2 COL4A4 COL4A3 COL4A5 COQ2 MYH9 LMX1B ARHGDIA CD151 PODXL E2F3 LAMB2 ALG1 MYO1E NPHS1 WDR73 NPHS2 WT1 ANLN YARS1 ZMPSTE24 APOL3;APOL4;APOL1;APOL2 ITGB4 TTC21B PMM2 PDSS2 GPC5 EMP2 COQ6 ARHGAP24 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP5414%HOMO SAPIENS IDO metabolic pathway KYNU KMO KYAT3 TDO2 KYAT1 IDO2 TNF IDO1 GOT2-1 AADAT IFNG WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260710%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates USP44 OTUD7B AKT1 FOXO1-1 USP28 HIF1A LDHA OTUD6B MTOR PGK1 U2AF2 PGAM1 VHL PIK3CA KDR G6PC1 USP7 FBP1 MYC SLC2A1 HK2 VEGFA OTUB2 USP37 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260710%WP2855%HOMO SAPIENS Dopaminergic neurogenesis NKX6-1 PITX3 GBX2 EN2 EN1 LMX1A TGFB1 STAT3 SLC18A2 CDKN1C ASCL1 LMX1B FGF8 DDC SHH OTX2 ALDH1A1 SLC6A3 NEUROD1 NR4A2 RET WNT1 MSX1 GLI1 SOX2 GLI2 TH NKX2-2 FOXA2 NEUROG2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260710%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DROSHA ERI1 DICER1 AGO2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MAP3K2 CBL HRAS BCLAF1 SHC4 SPAG1 HSPB2 BCL9 PIK3CA MAPK14 DOK1 PIK3R1 MAPK11 SOS1 CRK NRAS HSPB1 BCL2 SRC ARAF RAF1 MAPK1 AKT2 AKT3 VAV1 MAPK3 AKT1 KRAS ABL1 EIF4B BCR BCAR1 SHC3 SHC1-1 PXN ATF2 SHC2 INPP5D BRAF PTK2 GRB2 CRKL MEF2C GAB2 RPS6KA1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260710%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A1 AKR1A1 CYP1B1 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260710%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis SRD5A2 CYB5A CYP11A1 HSD3B1;HSD3B2 CYP17A1 STAR HSD17B3 HSD17B6 POR AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260710%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways NFKB1 PLEKHM1 TNFSF11 IKBKB CLCN7 TNFRSF11A TCIRG1 OSTM1 SNX10 RAB7A TRAF6 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260710%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ZYG11B NAE1 ELOB ELOC-1 CUL2 UBA3 CBFB RBX1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260710%WP1772%HOMO SAPIENS Apoptosis modulation and signaling TNFRSF25 TP53 BNIP3 MAPK8 HSPA1A;HSPA1B BCL2L11 BMF BAK1 BID MCL1 JUN CDKN2A CFLAR PIDD1 AIFM1 PEA15 ENDOG SEPTIN4-1 PTRH2 BIRC7 NAIP BCL2 BLK FAS BAG3 BAX BCL2L1 CAPNS1 PRKD1 APAF1 TRADD CASP9 CYCS-1 CASP7 TNFRSF1B CASP8 TRAF3 HTRA2 CASP3 IL1R1 PMAIP1 RIPK1 FADD BIRC3 BIRC2 CASP5;CASP4 NFKB1 TOLLIP CASP2 BBC3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BCL2A1 BCL2L10 BCL2L2 AIFM2 BOK BIK IRAK1 BAD MAP3K14 IKBKB MAPK3 MYD88 HRK FASLG CASP6 CASP10 IL1R2 CASP1 TNFSF10 DFFB DAXX DFFA MAP3K5 XIAP CRADD DIABLO-1 SMIM40 FOS BIRC5 NFKBIA TNFRSF1A MADD PTPN13 TRAF6 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260710%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC25A11 SLC1A3 MDH1 GOT2-1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260710%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 CYP2R1 AGTR2 ACE2 ACE AGT AGTR1 REN LEPTIN SIGNALING%WIKIPATHWAYS_20260710%WP2034%HOMO SAPIENS Leptin signaling FOXO1-1 SOCS3 MAPK8 EIF4E STAT5B PTPN11 PDE3B MAPK14 RPS6 IRS1 KHDRBS1 SOCS7 RAF1 KPNA4-1 REL AKT1 ACACA GSK3A PIK3R2 PLCG1 PTK2 NFKB1 GRB2 JAK2 CFL2 GSK3B PTEN RPS6KA1 RAC1 PTPN1 HRAS CISH ERBB2 STAT3 PRKAA1 ACACB CREB1 PRKAA2 BAD SOS1 PIK3R1 ROCK1 CHUK ROCK2 EIF4EBP1 NCOA1 SRC ESR1 RELA MAP2K2;MAP2K1 IKBKB MAPK1 SP1 SH2B1 IKBKG CDC42 MAPK3 LEPR LEP MTOR FYN RPS6KB1 SHC1-1 JAK1 NOS3 ELK1 RHOA PLCG2 STAT1 SOCS2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260710%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma FZD6 FZD9 CTBP1 FZD10 RYK-1 CCND1 ROR1 JUN TPTEP2-CSNK1E;CSNK1E ROR2 FZD1 EZH2 CSNK1A1 FZD7 CCND3 FZD8 CCND2 SFRP4 PLAU MYC SOX7 CER1 WNT5B CTNNBIP1 WNT5A KREMEN1 SENP2 TCF7 SFRP5 CXXC4 NKD1 NKD2 WNT6 DVL1 NOTUM DVL2 DVL3 WNT1 PORCN WNT2 SFRP1 WNT3 FRAT2 WNT4 WNT10B WNT10A SOX17 WNT3A WIF1 DKK4 SOST FOSL1 SERPINF1 WNT2B DKK2 DKK1 GSK3B AXIN1 WNT16 LEF1 LRP5 MTDH WNT11 FZD5 TCF7L2 FZD2 TCF7L1 SFRP2 WNT7B WNT7A NLK APC CTBP2 CSNK2B KLF4 LRP6 ELAVL1 CSNK2A2 CSNK2A1;CSNK2A3 FZD3 CTNNB1 CHD8 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP707%HOMO SAPIENS DNA damage response TP53 BID CCND1 PIDD1 RAD17 CDC25A CCND3 CCND2 FAS CCNE1 BAX MYC MDM2-2 AKT1 APAF1 FANCD2 GADD45A CDK5 CASP9 CYCS-1 HUS1B CHEK2 RFC1 CASP8 TLK1 CASP3 CHEK1 RPA2 MRE11 PMAIP1 CDC25C RAD52 DDB2 RAD50 RAD51 SESN1 CCNE2 NBN PRKDC ATM CCNB3 CDKN1B BBC3 CDK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SFN RAD9A GADD45B BRCA1 GADD45G PML ATR SMC1A RRM2B CCNB2 CCNB1 CREB1 RAD1 ATRIP ABL1 CDK1 TLK2 RB1 CDKN1A E2F1 CDK6 CDK4 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260710%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST1 HS3ST2 EXT1 EXT2 HS6ST1 HS6ST2 B4GALT7 HS6ST3 NDST2 HS3ST3B1 NDST1 XYLT1 NDST4 NDST3 CHST7 CHPF HS3ST3A1 XYLT2 EXTL2 EXTL1 DSE CHST15 CHSY3 CHST1 EXTL3 CSGALNACT1 CHPF2 B3GAT3 CHST3 B3GAT2 CHST11 GLCE CHST12 B3GAT1 CSGALNACT2 B3GALT6 CHST13 CHSY1-1 CHST14 UST HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260710%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy LDHA HIF1A GPD1 TPI1 SLC2A1 GPAT3 GAPDH-1 CD36 PPARG EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260710%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria RBBP4 TP53 CHD4 CHD3 MTA2 MBD3 LEF1 SREBF1 KDM1A H3-3A RB1 MBD2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 INPP5K SUV39H1 RBBP7 E2F1 CBX3-1 HDAC2 CBX5 CBX1 MTA3 HDAC1 MTA1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260710%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON1 LIPA CES5A PON3 PON2 CES2 ESD CES1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260710%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2C POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J;POLR2J2;POLR2J3 TAF12 TAF7 TAF6 TAF5 NELFCD NELFA NELFE MED23 TAF13 TAF8 MED27 TAF2 POLR2L THRA ERCC3 POLR2D MED14 MED19 MED16 MED1 MED18 MED17 MED12 MED11 MED13 MED10 NELFB MED8 MED9 MED4 GTF2F1 MED26 MED6 MED15 MED29 MED7 MED22 MED25 MED24 MED21 MED20 GTF2A1 MED28-1 CTDP1 CCNC-1 MED30 POLR2M TAF10 TAF11 MED31-1 TAF4 TAF3 TAF1 CDK8 TBP ELK1 GTF2B TAF9 GTF2E2 POLR2A POLR2B MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis SRD5A2 SRD5A1 CYP11B1;CYP11B2 HSD11B1 HSD11B2 AKR1D1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP21A2 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260710%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair RNF8 RAD54L MDC1 RNF168-1 H4C1 H4C6 H4-16 NASP-1 TP53BP1 XRCC6 RAD51 SUPT16H PRKDC XRCC5 NBN NAP1L1 SSRP1 SETD2 ATM AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260710%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MPO ORAI1 CACNA1F TRPC1 FKBP1A PRG3 TNF DMD CACNG1 CACNA1S NOX4 SLC25A5 IL6 CYBB STIM1 PLAU DTNA SSPN CAPN3 TRPC3 SNTB1 CASP9 SMAD2;SMAD3 GLI1 CCN2 SMAD4 PLA2G4A MMP9 IL1B NFKB1 PLA2G2A-1 NOS2 DAG1 ITPR1 CAMK2D IL10 TRPC6 TGFB1 RYR1 PRKAA1 PRKAA2 PPIF TNNI1 ITPR2 ITPR3 TOMM20 VDAC1 MCU ATP2A1 MCUB CASQ1 SCX SERPINE1 TRDN TGFBR1-1 SARAF ELANE HSPA9 GP2 SGCA IL1A AGTR1 FGB FGA TGFBR2 CACNA2D1 FGG SIGMAR1 CACNB1 CACNB2 MMP2 SPP1 NFKBIA PEPTIDE GPCRS%WIKIPATHWAYS_20260710%WP24%HOMO SAPIENS Peptide GPCRs CX3CR1 SSTR2 TACR3 OXTR GRPR CCR6 C5AR1 CCR5 CCR10 EDNRA NPY5R EDNRB C3AR1 AVPR2 TSHR OPRM1 SSTR1 TRHR SSTR3 SSTR4 SSTR5 FPR1 FPR2 MC2R OPRL1 GALR3 GALR2 CXCR1 GALR1 CXCR2 NTSR1 NTSR2 NMBR OPRK1 HCRTR2 HCRTR1 NPY4R2;NPY4R BRS3 CCR9 CCR8 CCKAR AVPR1B CXCR5 CXCR6 AVPR1A MC3R CCKBR FSHR GHSR OPRD1 MC1R MC4R CXCR4 BDKRB2 CXCR3 BDKRB1 CCR7 TACR1 MC5R CCR4 CCR3 ATP8A1 CCR2 GNRHR TACR2 AGTR1 CCR1 TAC4 NPY2R ACKR1 AGTR2 LHCGR NPY1R COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260710%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway COLEC11 C6 ACE2 C7 FCN2;FCN1 C8A C9 C3-1 MASP2 C5AR1 C5 C3AR1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260710%WP5598%HOMO SAPIENS Sodium channel in epilepsy TNF SCN8A SCN2A FGF14 PRRT2 SCN5A FGF13 FGF12 NEDD4L AKT1 NEDD4 FYN WEE1 CAMK2A PTPRN SCNM1;TNFAIP8L2-SCNM1 SCN4B PDCD10 SCN11A SCN10A SCN9A RACK1 JAK2 CALM1 SCN7A SCN1A SCN3B SCN3A BACE1 SCN1B MAPK8IP2 NFASC SCN4A GSK3B SCN2B PSEN1 RNF121 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260710%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells NLRP7;NLRP2 PRKCQ ELF3 PTPN6 RAC1 LAT HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ITPR1 TNF FYN PRKCA PTPN2 PLCG1 CSF2 SYK VAV1 IFNG TYROBP LCP2 OVARIAN INFERTILITY%WIKIPATHWAYS_20260710%WP34%HOMO SAPIENS Ovarian infertility EGR1 FMR1 ZP3;POMZP3 SMPD1 NR5A1 FIGLA DAZL NCOR1 MSH5 GJA4 DMC1 ZP2 CREB1 FSHR TSC1 CCND2 PTGER2 INHA MLH1 CEBPB NRIP1 AKT1 MTOR SMAD2;SMAD3 BMPR1B TSC2 PRLR VDR GDF9 TBP PGR ESR2 CYP19A1 RAD51 SYNE2 LHCGR ATM CDKN1B CDK4 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260710%WP5360%HOMO SAPIENS KCNQ2 related epilepsies ITPR1 BDKRB2 PPP1R10 PRKCA CSNK2A1;CSNK2A3 AGTR1 P2RY1 STX1A ANK3 CALM1 AKAP5 KCNQ2 BACE1 PRKACA-1 PLCG2 SCN1B CHRM1 PPP3CC KCNQ3 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260710%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3CD PIK3R5 PIK3CB PIK3R2 PIK3CA PIK3R3 PIK3R1 PIK3R6 PIK3C2G PIK3C2A PIK3CG PIK3C2B STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260710%WP383%HOMO SAPIENS Striated muscle contraction pathway DMD MYOM1 MYBPC3 MYBPC1 MYBPC2 ACTC1;ACTG2 TMOD1 ACTN4 DES TNNI1 TNNI2 TNNI3 TPM4 TPM3 TNNC1 TPM1 TNNC2 ACTA2 NEB ACTG1 MYL4 ACTA1 MYH3 TPM2 MYL1 TNNT1 TNNT2 MYL2 MYL3 TNNT3 MYH8 MYH6 VIM ACTN3 ACTN2 TTN-1 TCAP MAPK CASCADE%WIKIPATHWAYS_20260710%WP422%HOMO SAPIENS MAPK cascade MAP3K2 MAP3K3 HRAS SOS2 MAP2K7 MAP2K6 JUN MAP2 MAP3K1 MAPK14 SIPA1 MAPK12 PLCB3 SOS1 NRAS ARAF MAP2K2;MAP2K1 LAMTOR3 RAF1 MAPK1 MAPK3 MAPK10 KRAS RASA3 MBP ELK1 MAP3K12 BRAF MAP2K3 GRB2 MAP2K4 RRAS KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids CHKA PTDSS1 PISD PTDSS2 ETNK2 CEPT1 CHKB ETNK1 PCYT2 PEMT CHPT1 SGPL1 PCYT1B PCYT1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260710%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway SMPD1 SGMS2 UGCG KDSR CERS4 SGPP1 CERS3 DEGS1 CERS5 CERS2 CERS6 CERK DEGS2 SGMS1 PLPP3 UGT8 PLPP2 CERS1 SGPL1 SGPP2 PLPP1 SPTLC1 ASAH1 SPHK2 SPHK1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260710%WP322%HOMO SAPIENS Osteoblast signaling ITGAV IBSP PDGFRB PDGFB PTH1R FGF23 SLC17A2 TNFSF11 PDGFRA PTH ITGB3 COL1A1 TNFRSF11B HINT1 PATHWAY%WIKIPATHWAYS_20260710%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 GTF2H1 JUN GTF2H3 MITF GTF2H4 NFATC2 RUVBL1 NFKB1 CDK7 KARS1 ERCC3 USF2 HINT1 RUVBL2 TCF4 SH3RF1 ERCC2 CTNNB1 GTF2H2C;GTF2H2C_2;GTF2H2 FOS CCNH MNAT1 TP53 NETWORK%WIKIPATHWAYS_20260710%WP1742%HOMO SAPIENS TP53 network TP53 GADD45A SUMO1 TP63 ABL1 PMAIP1 BID BOK CDKN2A CDKN1A TNFSF10 BCL2 BAX ATM MYC TP73 MDM2-2 BBC3 OTX2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260710%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 PPARGC1A RET FBXO32 CDKN1A EP300 ESR2 ADRB2 MYOG MYC MYOD1 TRIM63 DUX4;DUXA VEGFA MYF5 UPF1 PAX7 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL17A IL17RC HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TNF IL12RB1 CXCL8 IL22 STAT3 IL12B CCL20 IL1B IL23R CXCL2;CXCL3;CXCL1-1 JAK2 CCR6 IL23A IL17F TYK2 GDNF SIGNALING%WIKIPATHWAYS_20260710%WP5143%HOMO SAPIENS GDNF signaling FMOD FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260710%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins FAF1 MAPK8 LMNA TNF PARP1 RIPK2 JUN CFLAR MAP3K1 MAPKAPK3 MAPKAPK2 HSPB1 BCL2 FAS PAK1 MAP3K7 SPTAN1 LMNB1 ACTG1 PAK2 ACTA1 NFX1 APAF1 CASP9 CYCS-1 CASP7 CASP8 CASP3 FADD RB1 IL1A FASLG CASP6 CASP10 DFFB DAXX PRKDC DFFA MAP2K4 ACTB-1 SMIM40 ARHGDIB LMNB2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260710%WP399%HOMO SAPIENS Wnt signaling and pluripotency CTNND1 CCND1 EP300 FZD1 FZD7 FZD8 PRKD1 NKD1 NKD2 GSK3B CD44 PTPA NLK CTBP2 PRKCD PPARD LRP6 PRKCQ PPP2R1B PPP2R2A;PPP2R2D PRKCG PRKCI PRKCH MAP2K4 PRKCZ RACGAP1 PAFAH1B1 TP53 FZD6 FZD9 CTBP1 ZBTB33 WNT9B FZD10 CREBBP JUN TPTEP2-CSNK1E;CSNK1E CCND3 CCND2 PLAU MYC MAP3K7 WNT5B WNT5A PPP2CB;PPP2CA FBXW2 TCF7 LRRK2 MMP7 PPM1J WNT6 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A SOX2 WNT3A PPP2R3B FOSL1 PPP2R3A PPP2R2C PPP2R2B WNT2B ESRRB PPP2R5E AXIN1 PPP2R5C POU5F1;POU5F1B WNT16 LEF1 LDLR LRP5 MAPK9 FZD5 WNT11 FZD4 PRKCB FZD2 TCF7L2 TCF7L1 WNT7B WNT7A NANOG;NANOGP8 APC PRKCE MAPK10 NFYA-1 PRKCA FZD3 PPP2R1A RHOA FOXD3 CTNNB1 AXIN2 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260710%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling CEBPA AXIN1 TLE1 LMNA HES1 HES5 LEF1 TARBP2 SREBF1 CCND1 CEBPD TCF7L2 HMGA2 TCF7L1 ADIPOQ DICER1 CSNK1A1 APC CEBPB TCF7 AGO2 TOR1AIP1 FNTA ICMT EMD WNT10B ZMPSTE24 SPP1 SLC2A4 CTNNB1 RUNX2 CDK6 GSK3B PPARG INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260710%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy DLAT PGLS MITF PKM ACSS1 NAMPT CPT1A DLD ARAF MAP2K2;MAP2K1 G6PD SLC16A3 RAF1 MAPK1 PFKFB2 GPX4 SLC1A5 MAPK3 LDHB LDHA PPARGC1A MTOR RPS6KA3 PDHA1 RPS6KA2 SLC16A1 PKLR MLST8 BRAF SLC2A1 GLS GSR RPTOR TRAP1 RPS6KA1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260710%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators TNF IL21 IL22 CCL23;CCL15 IFNL2;IFNL3;IFNL1 IFNK IL18 EBI3 CCL11 CCL4L2;CCL4L1;CCL4 CCL13;CCL2 CXCL8 IL25 IL33 CXCL5;CXCL6 CCL22 IL12B CXCL11 CCL21 CCL20 IL13 CXCL2;CXCL3;CXCL1-1 CCL27 CCL26 CXCL12 IL23A CXCL13 IL17F IL17D IL17C CCL28 IL17B IL17A MMP1 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 IL15 CCL5 CSF2 CXCL10 IL7 IL9 CXCL9 AREG SPP1 OSM IFNG LIF CCL8 CCL1 IFNB1-4 IL2 CNTF IL1RN IL6 IL36A IL36B TSLP XCL1;XCL2 CCL17 IL36G PPBP CCL16 IL1F10 MMP3 CSF1 MMP9 IL1B NFKB1 IL20 IL26 IL24 IL27 VEGFA CX3CL1 IL11 IL19 CTF1 CCL14 IL10 CCL19 TGFB1 IL4 CCL25 IL5 CCL24 IL12A IL31 IL37 CSF3 EPO CXCL17 IL3 CXCL14 IL1A IL36RN TNFSF13B LTA IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260710%WP5172%HOMO SAPIENS Iron metabolism disorders UQCRFS1 HFE FTL-1 CYBRD1 TF HEPH SLC11A2 HJV FTH1 CP TFRC TFR2 SLC40A1 BCS1L HAMP STEAP3 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260710%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling EGR1 HTR7 SRF ELK4 NR3C1 RPS6KA5 RAP1A ELK1 CREB1 BRAF MAPKAPK2 ATF1 HTR4 GNAS-1 MAP2K2;MAP2K1 HTR6 MAPK1 MAPK3 METHYLATION PATHWAYS%WIKIPATHWAYS_20260710%WP704%HOMO SAPIENS Methylation pathways MAT1A COMT HNMT MAT2A NNMT MAT2B PNMT INMT TPMT NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling PIK3CD EGFR FN1 MAPK8 HRAS MAPK9 ITGA1 MAPK14 MAPK12 MAPK13 ITGB1 MAPK11 SOS1 NRAS SRC MAP2K2;MAP2K1 RAF1 MAPK1 AKT3 MAPK10 KRAS TLN1 PXN AREG PTK2 GRB2 COL1A1 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome RAC1 CDC27 AMER3 PLEKHB2 MZT2A;MZT2B STAT3 STMN2 FAM168B GPR148 CCDC42 RHOA ARHGEF4 APC 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5407%HOMO SAPIENS 15q11q13 copy number variation CREBBP CXADR KLF13 OTUD7A TRPM1 FANCD2 FAN1 CDC42BPB STXBP1 SPEF1 SMC5 SMC6 STX1A NSMCE3 NSMCE2 CALM1 NSMCE1 EID3 GJD3 CANX NECAB3 SIN3A LYPD6 UBN1 GCOM1;MYZAP TRPM3 FANCI RIC3 SLF1 SLF2 FAM189A1 CGN DNMBP APBA2 TJP2 MITF CHRNA7;CHRFAM7A GJC2 SERPINH1 RELA CCL5 OCLN-1 TJP1 MTMR10 TJP3 GJA1 KAT2B APP ANKRD2 HDAC1 MONOAMINE GPCRS%WIKIPATHWAYS_20260710%WP58%HOMO SAPIENS Monoamine GPCRs CHRM3 HTR7 HTR2B HRH1 HTR2A HRH2 DRD1 DRD3 HTR1E DRD4 HTR1F DRD5 HTR1D HTR1A ADRB3 HTR1B ADRA1D ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1B HTR4 ADRA1A HTR6 CHRM4 CHRM5 DRD2 HTR5A CHRM2 CHRM1 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260710%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium HES1 NTRK1 KDM1A SEMA4A ID2-1 DLL1 ASCL1 TCF4 MYC MAP1B NGFR CDK5 DISC1 NDEL1 MRE11 RET NRG1 SOX2 HEY1 RTN4R MECP2 ERBB4 CXCL12 MEF2C GHRL GSK3B IL17A NOTCH1 FAIM LRP8 NTRK3 NEURL1 NEUROG3 RTN4 STAT3 DAB1 MAP2 CDK5R1 MARK2 NTRK2 BDNF JAG1 VLDLR PAX6 NUMBL NEUROD1 AGRN ID1 NUMB RELN APP PLXND1 NGF MAPT PAFAH1B1 PSEN1 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260710%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol IL17A CYP8B1 EBP CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP46A1 ACOT2;ACOT1 SCP2 ESR1 NR1H2 INSIG1 NR1I2 CH25H SULT2B1 CYP27A1 ACOT9 CYP39A1 DHCR7 SULT2A1-4 HSD3B7 BAAT CYP7B1 AMACR ACOX2 THEM5 SLC27A5 IL25 ACOT8 ACOT7 LBP ACOT11 ESR2 GPR183 ACOT12 ACOT13 ACOT6 ACOT4 HSD11B1 HSD11B2 AKR1D1 CYP7A1 RORC SLC27A2 DBP EPHX2 IL17F IL17D IL17C IL17B PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260710%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD8B;CD8B2 PRG3 HLA-DRA FYN CD8A CD2 CXCL8 CD4 LBP CD3G CD3E CD247 IGLL5;IGLL1 IL6 MMP25 NKRF ZAP70 LCK CRP ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260710%WP3878%HOMO SAPIENS ATM signaling in development and disease TP53 MDC1 DCLRE1C RIF1 ATR PPM1D KAT5 RBBP8 SMC1A HMGN1 RNF20 MAPK14 TP53BP1 ATMIN-1 MAPK12 AURKB RNF40 MAPK13 PPP5C MAPK11 CEP63 HDAC4 CDC25A HSPB1 STK11 TRIM28 G6PD PPP2CB;PPP2CA IKBKG RNF8 CDK5 MTOR BUB1 CHEK2 CHEK1 MRE11 TSC2 RNF168-1 ATF2 RAD50 PRKDC NBN NFKB1 NHEJ1 ATM LMNB2 CDK2 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260710%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IKBKE F3 ITPR1 NFKBIE IFNB1-4 TBK1 NLRX1 IL1B GSDMD CGAS NFKB1 NLRP3 CHUK RELA IRF3 IKBKB NFKBIA REL IKBKG STING1 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260710%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GGCT DPEP1 GGT1 OPLAH GCLC GSS PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260710%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260710%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis APAF1 CASP9 CYCS-1 CASP7 HTRA2 CASP8 BAK1 CASP3 BID PRF1 FADD CFLAR FASLG CASP6 AIFM1 ENDOG BCL2 FAS DIABLO-1 BAX PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260710%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways GRIA1 CBL EGFR FZD6 FN1 MAPK8 FZD9 ACTR2 FZD10 STAT5A JUN FZD1 FZD7 FZD8 MYC RAF1 PPP2CB;PPP2CA AKT1 DVL1 PFN3 SOD1 PLCG1 PTK2 ERBB4 GRB2 PFN1 CDKN1B PIK3CG GSK3B MYLK AXIN1 NOS1 WNT16 WNT11 FZD5 ERBB2 FZD4 FZD2 SOS1 APC ROCK2 NEFH SRC DAAM1 PFN2-1 MAP2K2;MAP2K1 GPX1 PAK1 ACTR3-1 MAPK1 ACTA1 MYL1 TGFA SHC1-1 NEFL NCK1 CAMK1 NEFM CDKN1A FZD3 ELK1 RHOA MAP2K4 CTNNB1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260710%WP391%HOMO SAPIENS Mitochondrial gene expression ESRRA PPARGC1B PPP3CA PPARGC1A TFB2M PPRC1 CAMK4 POLRMT MYEF2 GABPB1 CREB1 GABPA MTERF3 MTERF1-1 SP1 NRF1 HCFC1 TFB1M TFAM-1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260710%WP4150%HOMO SAPIENS Wnt signaling in kidney disease FZD6 MAPK8 FZD9 WNT16 WNT9B LRP5 MAPK9 WNT11 FZD5 FZD4 FZD2 FZD1 WNT7B FZD7 WNT7A FZD8 WNT5B LRP6 NPHP3 WNT5A MAPK10 WNT6 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 WNT10B FZD3 WNT10A WNT3A RHOA INVS WNT2B CTNNB1 PURINE METABOLISM%WIKIPATHWAYS_20260710%WP4792%HOMO SAPIENS Purine metabolism PNP-1 PRPS1 XDH ADSL ATIC ADA IMPDH1 HPRT1 ADSS2 DGUOK AMPD1 APRT ITPA TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260710%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR JAK1 MAPK1 STAT3 MAPK3 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260710%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway ACE2 MMP1 GSTA3;GSTA5;GSTA1;GSTA2 KEAP1 RXRA TMPRSS2 TNF GUCY1A2 GUCY1A1 IL12A IL6 CHUK RELA IKBKB NQO1 GCLC IKBKG GCLM NOX1 HMOX1 CCL13;CCL2 CXCL8 MMP3 IL1B NFKB1 GUCY1B1 NFE2L2 IRF3 SLC7A11 NFKBIA PRKG2 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome MAPK8 PCNA RIF1 CDH1 HSF1 SLC18A3 SIRT6 DLD BCL2 MYBBP1A DDX21 BMPR1B BMPR1A GDF5 ERCC5;BIVM-ERCC5 MYO1C ITCH SMARCB1 JUND SMARCC2 ERCC8 ERCC6 CUL5 CLOCK NEO1 ARNTL SIRT1 SMAD1 NLRP3 SMAD9 DLST SMAD5 FRMPD2 OGDHL EIF4ENIF1 BMP2 FAM170B VSTM4 MEN1 C10orf71 RGMB BAZ1B WDFY4 PARG SF3B1 LRRC18 CHAT ARHGAP22 ATF2 HSF4 DRGX KDM4D ELK1 NOG C10orf53 SMARCA5 DEK TMEM273 UVSSA ELOA HIPPO YAP SIGNALING%WIKIPATHWAYS_20260710%WP4537%HOMO SAPIENS Hippo YAP signaling LATS2 RASSF1 STK3 YAP1-1 SAV1 STK38L WWTR1 TNIK MAP4K1 MAP4K2 NF2 MINK1 TEAD1 TEAD2 TEAD3 TEAD4 MST1 NDRG1 CXCL10 MAP4K3 LATS1 MAP4K4 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260710%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 NFKB1 TNF ICAM1 IFNAR1 TNFRSF1A NOX1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260710%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EGR1 KEAP1 HSPA1A;HSPA1B FABP1 TNF CCND1 SLC6A6 EP300 SLC6A8 SLC5A5 SQSTM1 ME1 PCK1 SLC7A5 HMOX1 SOD3 GGT1 ETNK2 NRG1 FASN PTGS2-2 JUND NFE2L2 SLC2A1 AHR SLC2A4 SREBF1 AMIGO2 SLC19A2 STAT3 SMC1A PTPA NCOA1 PPARD ABCB1 NR1I2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SRPX2 NRIP1 PPARGC1A NCOA2 CDC37 NCOA3 PSMC5 TGFA CDK1 DNAJC7 KAT2B ABCC5 TGFBR2 TGFBR3 JUNB HSP90AA1 IFNG CDK4 TXNRD3 HBEGF EGFR BLVRB JUN DNAJB1 LRRC8A IL2 SCP2 BAX MYC FGF13 NR1H3 HSP90AB1 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SCD SLC27A5 AKAP13 SLC5A7 SLC39A4 PDE4B HGF ACKR3-2 IL1B NFKB2 ABCC3 ABCC4 ABCG8 TGFB2 CDKN1B ABCG5 CBR1-1 ABCC2 SLC10A1 ABCB4 NR1I3 SMARCA1 SNAI2 IL11 NR1H4 RGS2 ABCB11 RXRA FTH1 SLC39A8 TGFB1 SLC39A14 IL12A ESR1 G6PD SP1 GCLC GCLM STOM VDR ALOX5AP PTGR1-1 GCC1 PDK4 TNS4 SEC14L1 SLC7A11 PLK2 CAP2 IRS2 NR0B2 ANKRD1 CPEB4 THBD EPB41L4B AGER DNER ENC1 FGFBP1 EDN2 FOXO1-1 TSC22D3 SERPINB9 SLC39A2 SLC6A19 CDC42EP3 SLC39A1 AHRR SLC39A3 HES1 PMP2 GPR153 SERTAD2 CAVIN2 SERPINB2 ACAA1-1 PPARA KLK15 PGD KTN1 SLCO2B1 AIP SCNN1A SLC26A2 ABHD2 IP6K3 DNAJC15 ALAS1 CDKN1C ARL5B SRGN NAV3 ACOX1 APOC3 ADGRF4 NQO1 PTGES3-1 PRRG4 PPP1R14C TXNRD1 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2A1-4 TXN CCL13;CCL2 MGST3 MAFF MGST1 MGST2 IL12B PDGFB CYP2B6 CCL20 SLC5A1-1 CUL1 GSTM4 FGF19 GSTM3 FKBP5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GSTA3;GSTA1 CES2 CES1 IL17B CYP1A2 GADD45B CYP1A1 GSTA3;GSTA5;GSTA1;GSTA2 MYOF POLK UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SPRY1 ARNT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MFGE8 FGD4 CYP2C9;CYP2C19 UGT1A1;UGT1A6 GSTT2B;GSTT2 FTL-1 BAAT GSTP1 SLC27A1 B3GNT5 CYP7A1 SRXN1 CYP2A13;CYP2A6;CYP2A7-1 S100P GSR APOA2 GSTM1;GSTM2-1 APOA1 SLC39A9 CYP8B1 SLC39A6 SLC39A5 SLC39A7 APOA5 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A14 NCOA6 PLTP SLC5A6 GSTA4 ALDH3A1 SLC5A8 SLC5A9 CPT1A CES3 EPHA3 SLC5A2 SLC6A20 EHHADH-1 CES5A SLC5A3 SLC5A4 PRDX1 SLC2A9 SLC6A5 SLC6A7 ACADM SLC6A9 SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 SLC2A13 SLC39A11 MAFG SLC39A10 SLC39A13 SLC39A12 BIRC3 SLC5A11 SLC5A12 BIRC2 SLC5A10 CBR3 TNFAIP3 POU5F1;POU5F1B SRC ZIC2 ANGPTL4 SLC2A12 BHLHE40 GPAM NR3C1 CPT2 EPHA2 PRDX6 SLC2A2 SLC2A5 SLC6A13 IGFBP1 SLC6A11 SERPINA1 FOCAL ADHESION%WIKIPATHWAYS_20260710%WP306%HOMO SAPIENS Focal adhesion FN1 CCND1 KDR PPP1R12A TNXB PPP1R12C LAMA4 LAMC1 THBS2 BLK COL4A2 COL4A1 RAF1 COL5A3 COL6A2 COL5A2 SHC2 GSK3B PTEN RAC1 PIK3CD PIK3CB RASGRF1 PIK3CA TNC PIK3R3 PIK3R1 HCK PAK1 MAPK1 VAV1 MAPK3 PDGFD PDGFC ELK1 PRKCG COL2A1 XIAP RELN PDGFRA THBS1 SPP1 EGF COMP EGFR IBSP TNN MAPK8 TNR PGF COL4A6 CHAD JUN CCND3 CCND2 BCL2 ITGB3 LAMC3 LAMC2 VWF LAMA1 LAMA3 THBS4 THBS3 FLT1 HGF LAMB3 MET LAMB1 VEGFA COL1A1 COL1A2 MAPK9 ERBB2 PRKCB BAD ITGB1 ROCK1 ROCK2 ACTG1 CDC42 FYN PRKCA RHOA ACTN1 ACTB-1 CTNNB1 LAMA2 FLNA IGF1R MYL5 MYL7 TLN2 TXK MYL12A MYL12B MYL10 TNK2 SRMS PTK6 PARVB PARVG ARHGAP5 ARHGAP35 MYLK4 TNK1 FGR PPP1R12B STYK1 PDGFB VEGFB CRKL VEGFC VEGFD DIAPH1 ACTN4 COL4A4 FLNB FLNC LAMA5 VTN LAMB2 PARVA SHC4 MYLK2 BUB1B-PAK6;PAK6 ITGA2B PDGFA AKT2 AKT3 CAPN2 AKT1 PPP1CA TLN1 VCL PPP1CB SHC3 PPP1CC PXN PIK3R2 RAP1B BIRC3 RAP1A VASP BIRC2 CAV3 CAV2 CAV1 BRAF PTK2 ITGA10 ITGA11 GRB2 ITGB5 ITGB4 ILK MYLK3 MYLK RAC3 ITGB8 ITGAV ITGB7 ITGB6 HRAS VAV3 ITGA4 PDPK1 PDGFRB ITGA3 ITGA2 ITGA1 VAV2 ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 SOS1 CRK DOCK1 ITGA9 SRC IGF1 MAP2K2;MAP2K1 MYLPF PAK3 PAK2 PAK4 MAPK10 MYL2 ZYX BCAR1 SHC1-1 TESK2 PIP5K1C EMP2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260710%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 FECH UROD UROS ALAS1 PPOX CPOX HMBS ALAD UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4571%HOMO SAPIENS Urea cycle and related diseases CPS1 ASL NAGS ARG1 GLS2 SLC25A15 OTC SLC25A13 ASS1 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260710%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders F10 ASL F7 GATM GPT GAMT NAGS ARG1 GLS2 OTC GOT1-1 ASS1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP23%HOMO SAPIENS B cell receptor signaling FOXO1-1 CBL MAPK8 NFATC3 PIP5K1B PIP5K1A MAP2K6 PTPN11 JUN MAPK14 RASGRP3 BLK MYC MAP3K7 RAF1 PTPRC REL AKT1 CR2 BLNK LYN GSK3A PIK3R2 CD79A MAX NFATC2 CAMK2A INPP5D CD22 BRAF PLCG1 NFKB1 CD81 GRB2 MAP4K1 KLF11 BCL6 CRKL LAT2 BTK DAPP1 PIK3AP1 CD79B SH3BP2 PTPN18 TEC PIK3CG GSK3B RPS6KA1 RAC1 HRAS PDPK1 MAPK9 PRKCB VAV2 CARD11 RAPGEF1 GAB1 CREB1 SOS1 PIK3R1 CRK CHUK PRKCD RELA MAP2K2;MAP2K1 IKBKB MAPK1 SYK VAV1 IKBKG BCL10 CDC42 MAPK4 MALT1 PTPN6 ETS1 FYN SHC1-1 NCK1 CD19 ATF2 ELK1 LCK HCLS1 PLCG2 PIP5K1C NFKBIA GAB2 GTF2I UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260710%WP5158%HOMO SAPIENS Urotensin II mediated signaling CYBA EGFR FN1 MAPK8 PCNA TNF CREBBP ICAM1 PTPN11 HSPA2 EP300 FSCN1 MAPK14 NOX4 IL6 CYBB BCL2 COL3A1 CCNE1 BAX AKT1 ALOX5 CASP9 SMAD2;SMAD3 HMOX1 CASP3 GSK3A HDAC5 ABCA1 VCAM1 CAMK2A MMP9 IL1B NFKB1 JAK2 DDIT3 COL1A1 TRPC4 GSK3B CDK2 PTEN NPPB NPPA MAPK9 AIFM2 TGFB1 STAT3 CHUK ESPL1 RELA IKBKB PRKACA-1 ACTA2 MAPK1 MAPK3 CDK1 AGTR1 RHOA NCF1 COL2A1 NCF2 NCF4 IRF3 MMP2 CTNNB1 UTS2R DRAVET SYNDROME%WIKIPATHWAYS_20260710%WP5200%HOMO SAPIENS Dravet syndrome TNF SCN8A SCN2A PRR5 PIK3CA PRR5L MAPK11 MAPKAP1 RICTOR FGF13 SNTA1 AKT1 MTOR CHD2 PRKCA STXBP1 MLST8 CAMK2A NFKB1 SCN4B CALM1 SCN1A SCN3B SCN3A SCN1B KCNA2 SCN2B HCN1 PCDH19 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260710%WP5398%HOMO SAPIENS NRXN1 deletion syndrome DLG4 GRIA1 GRIA2 NRXN1;NRXN3;NRXN2 NLGN1 GRIA3 GRIA4 GRIN2A NLGN3 NLGN2 NLGN4X;NLGN4Y GRIN2C GRIN2B GRIN1 GRIN2D GRIN3B GRIN3A CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260710%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer TP53 MAPK8 BCL2L11 BAK1 CCND1 JUN CSNK1A1 BCL2 ARAF BAX MYC RAF1 AKT2 AKT3 MSH2 REL TCF7 AKT1 GADD45A CASP9 CYCS-1 SMAD2;SMAD3 CASP3 PMAIP1 DDB2 SMAD4 APC2 BRAF PTGS2-2 TGFB2 TGFB3 MSH3 GSK3B BBC3 RAC3 APPL1 RAC1 DCC AXIN1 GADD45B GADD45G POLK LEF1 MAPK9 RALA-1 TGFB1 TCF7L2 TCF7L1 RALGDS BAD APC MAP2K2;MAP2K1 RALB MLH1 MAPK1 NTN1 MAPK3 MAPK10 KRAS TGFBR1-1 TBK1 CDKN1A RHOA TGFBR2 MSH6 CTNNB1 FOS BIRC5 AXIN2 EXOC2 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260710%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway TP53 FOXO1-1 EGFR FN1 MAPK8 GRB14-1 GRB7 STAT5A STAT5B PTPN11 ANGPT1 MAPK14 MAPK12 TEK MAPK13 MAPK11 STMN1 BAX MYC MSH2 AKT1 CASP9 CASP7 PXN ANGPT4 ANGPT2 RAD51 PTK2 NFKB1 GRB2 RAC1 RS1 NOS1 TNIP3-2 HRAS ANGPTL1 NOS2 TIE1 TNIP1 TNIP2 MAPK9 RASA1 ERBB2 PIK3CA STAT3 BAD ITGB1 SOS1 PIK3R1 CRK NRAS CHUK EIF4EBP1 SRC RELA IKBKB PAK1 MAPK1 IKBKG MAPK3 KRAS NCK1 YAP1-1 MMP2 CTNNB1 BIRC5 NFKBIA DOK2 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260710%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling NODAL NKX2-1 SMAD2;SMAD3 TGIF2 TGIF1-1 FGF8 SHH FOXG1 GLI3 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260710%WP5300%HOMO SAPIENS TROP2 regulatory signaling RAC1 EGFR FN1 NOTCH1 TACSTD2 CCND1 MDK CDH1 JUN CLDN7 CDKN2A IGF2R ITGA5 ITGB1 PIK3R1 BCL2 SRC PRKCD CCNE1 BAX IGF1 IGF1R CLDN1 PAK4 TLN1 CHEK1 VIM RB1 PRKCA IGF2 ABCC1 MMP13 PTK2 ACVRL1 NFKB1 PECAM1 RACK1 JAK2 CDKN1B CTNNB1 PSEN2 STAT1 CDK4 CDK2 PTEN GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway FGFBP1 EDN2 TSC22D3 SERPINB9 CDC42EP3 PMP2 GPR153 SERTAD2 CAVIN2 JUN KTN1 SCNN1A LRRC8A SLC26A2 ABHD2 DNAJC15 CDKN1C ARL5B SRGN NAV3 ADGRF4 PTGES3-1 PRRG4 PPP1R14C BIRC3 CCL13;CCL2 ETNK2 AKAP13 BIRC2 PDE4B CCL20 ACKR3-2 CUL1 NFKB2 PTGS2-2 TNFAIP3 NR1I3 SNAI2 IL11 GADD45B RGS2 POU5F1;POU5F1B RXRA AMIGO2 SLC19A2 MGAM SPRY1 MFGE8 FGD4 ZIC2 ANGPTL4 NR1I2 STOM BHLHE40 NR3C1 ALOX5AP TGFBR3 B3GNT5 TNS4 HSP90AA1 SEC14L1 PLK2 ANKRD1 S100P THBD CPEB4 EPB41L4B DNER ENC1 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260710%WP5173%HOMO SAPIENS Disorders of galactose metabolism PYGL PGM1 AKR1B1 GALT GBE1 GALE GYG2 SLC5A1-1 GYG1 GALK1 GYS1 SLC2A2 GYS2 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260710%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA VDR PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260710%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GRIA1 TRPC3 GRIA2 GRM1 ITPR1 GNA15 GRIA3 GRIA4 ATP2B2 RYR3 PLCB3 CACNA1A PLCB4 GNAQ PRKCG HOMER3 GNA11 CA8 PLCB1 PLCB2 PDK1 GNA14 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260710%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK8 STAT6 MAPK9 STAT5A STAT5B PTPN11 FES STAT3 MAPK14 RPS6 EIF4EBP1 CRLF2 SRC RELA MAP2K2;MAP2K1 HCK MAPK1 MAPK3 TSLP AKT1 FYN LYN JAK1 YES1 NFKB1 NFKB2 RELB IL7R JAK2 BTK LCK STAT4 NFKBIA TEC STAT1 GAB2 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism ESRRA PPARGC1B MTTP NOS3 PPARA HADHB-1 ACLY STK11 ESR1 SLC2A4 APOB AKT2 SOD2 ACADM AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260710%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits JAG1 NOTCH1 LEF1 VHL WNT2 TCF7L2 VCAM1 TNC TCF7L1 EPAS1 POSTN SRC CYTIP CXCR4 VEGFA PIK3CG TCF7 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2276%HOMO SAPIENS Glial cell differentiation CNP MSN TPPP MAG GAP43 PLP1 MBP AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260710%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC1A1 SLC6A19 SLC7A7 SLC36A2 SLC6A20 CLTRN SLC7A9 SLC3A1 SPINA BIFIDA%WIKIPATHWAYS_20260710%WP5150%HOMO SAPIENS Spina bifida DNMT1 MAT1A AHCYL2 AHCY MTHFD1 MTRR MAT2B MTR-1 SHMT1 DNMT3B DNMT3A MTHFR MTHFR DEFICIENCY%WIKIPATHWAYS_20260710%WP4288%HOMO SAPIENS MTHFR deficiency DNMT1 MARS1 EHMT2 CASP9 CYCS-1 CHKA CASP3 ASMT EHMT1 DNMT3B DNMT3A MTHFR COMT HNMT BHMT GRIN2A PEMT ALDH7A1 CHPT1 CHDH GRIN1 GRIN2D NDUFAF7 PCYT1A MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260710%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids AKT1 HIF1A MTOR PIK3CA CERK TSC1 NFKB1 CERS1 ASAH2 PLD1 SPHK2 IGF1R S1PR1 S1PR3 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260710%WP3645%HOMO SAPIENS NAD biosynthetic pathways CD38 TDO2 SIRT3 QPRT PARP1 SIRT1 ACMSD TNKS NAMPT PARP4 SIRT6 NMNAT1 NADSYN1 NAPRT IDO1 BST1 SIRT4 SIRT5 SIRT2 PARP2 TNKS2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260710%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IRF7 ACE2 IKBKE IRAK4 TMPRSS2 TLR7 EIF2AK2 TLR9 TLR6 OAS3 TLR3 TLR2 IFNAR2 IFIH1 STAT2 OAS1 IFNAR1 MAVS TREML4 TRAF3 MYD88 JAK1 TBK1 DDX58 IRF3 STAT1 IRF9 TYK2 TRAF6 TLR4 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260710%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection ATF6 MBTPS2 MAPK8 PPP1R10 EIF2AK2 PPP1R7 ATF4 PPP1R12A PPP1R12C BCL2 PPP1R1B PPP1R14C PPP1R14A PPP1R15B PPP1R13B PPP1R11 PPP1CA PPP1R8;STX12 PPP1R2-1 PPP1R3A PPP1R9A PPP1CB PPP1CC PPP1R16B EIF2AK1 PPP1R14B PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R12B PPP1R3C PPP1R3B PPP1R3E PPP1R1C PPP1R3D PPP1R14D PPP1R15A MBTPS1 XBP1 HSPA5 EIF2AK3 EIF2S1 ERN1 DDIT3 MAP1LC3A PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260710%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells TP53 RPIA DERA RPE;RPEL1 G6PD TALDO1 PGLS MAPK SIGNALING%WIKIPATHWAYS_20260710%WP382%HOMO SAPIENS MAPK signaling NFATC3 HSPA1A;HSPA1B TNF NR4A1 MAPKAPK5 RAF1 TAOK2 DUSP1 RASGRP1 RPS6KA4 RPS6KA3 MAP3K8 MAP3K6 MAP3K13 MAP3K11 MAP3K12 PLA2G4A JUND MAP4K1 MAP4K2 FGF2 MAP4K3 MAP4K4 MAP3K2 RAC1 SRF RASGRF1 ELK4 RPS6KA5 ECSIT MAPKAPK3 CACNA1C NLK MAPKAPK2 NRAS NTRK2 PRKCD RELA LAMTOR3 BDNF PAK1 HSPA8 MAPK1 MAPK3 NF1 KRAS MKNK1 TGFBR1-1 ATF2 FASLG ELK1 FGF7 TGFBR2 PRKCG MAP3K5 MAP2K3 MAP2K4 NTF3 TRAF2 MAPK8IP2 FOS TNFRSF1A EGF FGF3 TRAF6 FGF5 TP53 FGF6 FGF9 FGFR2 EGFR MAPK8 FGF16 MAP2K7 NTRK1 MAP2K6 HSPA6 FGF20 HSPA2 JUN FGF22 FGF17 MAPK14 HSPA1L MAPK12 FGF14 MAPK13 MAPK11 FGF18 FAS MYC MAP3K7 FGF13 MAP3K4 FGF12 FGF11 LRRK2 DUSP3 GNA12 PTPN5 IL1R1 IL1B NFKB1 NFKB2 RELB TGFB2 MEF2C TGFB3 ARRB1 SOS2 ARRB2 PRKACB-1 MAPK9 TGFB1 MAP3K1 CACNA1B PPP5C CACNA1A CACNA1E CHUK IKBKB PRKACA-1 PPP3CC IKBKG CDC42 TAB1 CD14 PRKCA IL1A CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 NGF CACNA1D CACNA1F CACNG6 CACNG7 CACNG8 FLNA CACNG1 CACNA1S CACNG2 CACNG3 ATF4 CACNG4 CACNG5 STMN1 DUSP2 FGF1 PPP3R1 GADD45A CDC25B MAX PDGFB CRKL FGF19 FGFR4 DUSP6 HSPB1 FLNB FLNC CACNA1H MAPK8IP1 DAXX FGF23 MAPK8IP3 PTPRR DUSP4 DUSP8 DUSP9 SMIM40 DUSP7 RAPGEF2 TAOK3 CACNA1G MAP3K20 DUSP16 DUSP10 PPM1A PPM1B MKNK2 JMJD7-PLA2G4B;PLA2G4B PTPN7 STK4 RASGRP2 FGFR1 RASGRP4 RASGRP3 ARAF PDGFA RASGRF2 FGF4 FGF8 NTF4 AKT2 PLA2G4F AKT3 PLA2G4D FGF10 AKT1 PLA2G4E RRAS2 MRAS RASA2 CASP3 RAP1B RAP1A MAP2K5 BRAF GRB2 DDIT3 TAB2 RAC3 PPP3CA PPP3CB HRAS PDGFRB RASA1 CACNA1I MAP3K14 SOS1 CRK NFATC1 MAPK7 MAP2K2;MAP2K1 PAK2 FGF21 MAPK10 STK3 IL1R2 FGFR3 RRAS TAOK1 MAPT INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260710%WP585%HOMO SAPIENS Interferon type I signaling CBL SOCS3 SOCS1 EIF4E STAT5A MAP2K6 PTPN11 MAPK14 RPS6 IFNAR2 IRS1 MAPKAP1 STAT2 PIAS3 IFNAR1 PTPRC REL RPS6KA4 PIK3R2 RAP1A CRKL STAT4 RPTOR PIK3CD RAC1 PRMT1 PIAS1 RPS6KA5 STAT3 RAPGEF1 MAP3K1 CREB1 PIK3R1 CRK EIF4EBP1 VAV1 PTPN6 EIF4A1 MTOR FYN EIF4B RPS6KB1 PDCD4 JAK1 MLST8 MAP2K3 RACK1 ZAP70 LCK IRS2 GAB2 IRF9 STAT1 TYK2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260710%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy AKT1 NFKB1 RASGRF1 TGFB1 AKT2 STAT3 PPP3R1 MYEF2 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260710%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGA F13B F2 FGG F13A1 PLG FGB MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260710%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism UGT1A1;UGT1A6 SRD5A2 SRD5A1 CYP11A1 HSD3B1;HSD3B2 CYP17A1 HSD17B3 HSD17B2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP19A1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B3 SLC35B2 CANT1 XYLT2 PAPSS2 BPNT2-1 EXTL3 CSGALNACT1 SLC26A2 EXT1 B3GAT3 CHST3 EXT2 B4GALT7 B3GALT6 CHSY1-1 CHST14 XYLT1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260710%WP4815%HOMO SAPIENS Glycosaminoglycan degradation NAGLU HGSNAT HPSE2 IDUA HEXB GNS SGSH HEXA GALNS HYAL1 HYAL2 HYAL4 IDS HPSE GUSB ARSB GLB1 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260710%WP2003%HOMO SAPIENS miR targeted genes in leukocytes ARF4-1 PISD CAP1 PHC2 ZEB1 PKM IGF2R TMEM43 NELFCD CDIPT CSRP1 SRSF10 CHORDC1 TXN2 CDK5RAP1 TXNRD1 CDK5RAP3 IFRD1 HMOX1 AP3D1 MAP3K8 TMED10 FADS1 MRPL20 ANAPC1 ATP6V0A1 SNX6 POLE4 TRAM1 GYS1 USP1 MRC2 SFXN1 TMED3 CTSC GAK SLC7A6 CDCP1 VPS39 FRG1 BRPF3-1 DCAF7 RTN4 CA12 PTPA ARCN1 WDR11 ANXA2 TBCA RHOG LAMTOR3 ACAA2 TUSC2 ARID4B GNAI2 PNP-1 SPTLC1 RAB34 WDFY1 MATR3 PPIB SLC1A4 ADIPOR2 CORO1C RAB5C RAB6A CD164 THBS1 SNAP23 TNFAIP2 PLXND1 CDK6 LMNB2 TMEM109 ACP2 SCYL1 POLR2C RDH10 LPL MCL1 DNAJB1 ADAR MAPK14 KCNN4 PDLIM5 POM121;POM121C BCL2 SERPINE2 ATP6V0E2;ATP6V0E1 C1orf56 FMNL2 GOLGA7-1 SAC3D1 ARHGDIA ATP6V1F ADPGK PRSS21 PTRH1 UNC93B1 DDX5 GNA13 RFT1 SHOC2 TNFSF9 MPDU1 BCL6 HNRNPM CAPG PPIF PRPF40A TPM3 G6PD IDH1 ANPEP CEBPB TUBA1A YWHAQ SEC24A ATP2A2 TYMS SLC25A1 MTHFD2 SLC7A11 SH3BGRL3 CTNNB1 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260710%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function ADCY6 GRIA1 ADCY5 DRD1 ADCY10 PDE3B GUCY1A2 PDE1A GUCY1A1 PDE3A PPP1R1B PDE12 PDE5A PDE8A PDE9A PDE11A PDE6D PDE6C PDE6B PDE6A PDE6H PDE2A PDE10A PDE4B CAMK2A PDE4A ADORA2A PDE8B PDE4C PDE1C DRD2 PDE1B PDE4D-1 PDE7B PDE7A NOS1 ADCY4 ADCY2 CREB1 ADCY9 GRIN2A CHRNA7;CHRFAM7A GRIN2C PRKACA-1 GRIN2B GRIN1 GRIN2D PRKG1 GUCY1B1 ADCY3 ADCY1 ADCY8 ADCY7 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260710%WP183%HOMO SAPIENS Proteasome degradation UBE2D3;UBE2D2 PSMC6 PSMC4 PSMB9 PSMD2 PSMD12 PSMD13 UBE2D1 RPN2 UBE2D3-1 RPN1 PSMD5 H2AC4 UCHL3 PSME3 PSME1 PSME2 PSMD9 PSMD10 PSMD6 UBA7 PSMD4 PSMB10 PSMD3 UBE2B PSMD1 UBA1 PSMC2-1 PSMA5 PSMA6 PSMB8 PSMA3 PSMA4 PSMA1 PSMA7 UCHL1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMD8 PSMD7 PSMA2-1 PSMC3 PSMC1 PSMD11 UBB;UBC NEDD4 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSMC5 H2AZ2;H2AZ1 IFNG SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260710%WP15%HOMO SAPIENS Selenium micronutrient network MPO SELENOO F2 SELENON SAA2-SAA4;SAA4 F7 SELENOS TNF APOA1 SELENOT ICAM1 PLG KYNU PLAT DIO1 DIO3 KMO IL6 TXNRD2 PRDX1 TXNRD1 SOD2 GPX6 ALOX5 RFK SELENOP XDH TXN PTGS1 HBD;HBB SOD3 GGT1 CCL13;CCL2 ABCA1 SOD1 IL1B INSR ALOX15B NFKB1 NFKB2 PTGS2-2 CTH PNPO SCARB1 FLAD1 PRDX3 PRDX5 PRDX4 CAT LDLR INS;INS-IGF2 RELA GPX1 APOB GPX4 ALB SERPINE1 MTR-1 SAA2;SAA1 HBA2;HBA1 FGB MTHFR ALOX5AP FGA FGG SELENOK SELENOI PRDX2 SEPHS2 IFNG GSR CBS;CBSL CRP TXNRD3 SERPINA3 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260710%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling RASSF5 NOS2 IRAK4 TIRAP TNF IFNB1-4 PIK3CA PLG TLR3 IRAK1 PLAT IL6 CHUK SRC RELA IKBKB LY96 SYK IKBKG CXCL10 TYROBP REL AKT1 CBLB CD14 FCER1G MYD88 CCL13;CCL2 LBP FGB IL12B FGA TICAM2 RHOA FGG NFKB1 TICAM1 ITGAM CXCL2;CXCL3;CXCL1-1 IRF3 ITGB2 IRAK2 TRAF6 TLR4 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260710%WP2328%HOMO SAPIENS Allograft rejection TNF IL21 IL22 IL2RA C6 IL2 C8A C7 PECR C9 CD55 C1QB C3-1 FAS COL5A1 C2 FOXP3 C5 LOC110384692;C4A;C4B_2;C4B BHMT2 LRRK2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CASP9 CASP7 CASP8 CASP3 C1QC CXCL8 IL12B CXCL11 CCL21 IL1B IL13 CD40 CD28 CXCL12 CXCL13 VEGFA HARS1 GDNF IL17A HLA-DOA HLA-DOB CXCR5 PRF1 IL10 CD86 CCL19 TGFB1 CD80 HLA-DPB1-1 IL4 IL5 CTLA4 IL12A HLA-DPA1 HLA-DQB2;HLA-DQB1 HLA-DMA HLA-DMB ABCB1 C8B CSNK2A2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E HLA-DRA CXCL9 VIM GZMH;GZMB-1 IL1A AGTR1 FASLG CD40LG GABPA PDGFRA PRKCZ IFNG STAT1 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260710%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins GGCX F2 F10 F7 F9 PROC AIFM2 NQO1 VKORC1 VKORC1L1 UBIAD1 PROS1 JOUBERT SYNDROME%WIKIPATHWAYS_20260710%WP4656%HOMO SAPIENS Joubert syndrome FLNA BBS4 KAT5 ATF4 TTC8 CETN2 SHH ANKS6 DVL1 PDE6D PDE6B DVL3 PDE6A MRE11 NEK8 RAD50 OFD1-1 ATM CETN1 CEP164 CEP120 CCP110 ARR3 TCTN3 TCTN2 CSPP1 TCTN1 PARP1 CC2D2A ARMC9 TMEM138 CEP97 RP2 CEP290 TMEM216 CEP104 ARL3 ARL2 ARL13B TMEM67 INPP5E PCNT PIBF1 RAB3IP MYO5A CPLANE1 TMEM231 NIN TMEM17 NPHP3 BBS2 KIAA0586 BBS1 TMEM237 RHEB UNC119 B9D1 CEP41 B9D2 MTOR MKS1 AHI1 BBS9 MYO6 BBS7 BBS5 RAB8A RHOA INVS NPHP1 RPGRIP1L ZNF423 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260710%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders APTX RFK ETFDH ETFA COQ9 COQ7 SLC52A1;SLC52A2 PDSS1 COQ8A COQ2 FLAD1 PDSS2 COQ6 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260710%WP5294%HOMO SAPIENS Sildenafil treatment AKT1 PDE5A PPARGC1A NOS1 NOS2 PRKG1 ZNF746 NOS3 PRKN GUCY1A2 GUCY1A1 PDE4B PDE4A PDE4C GUCY1B1 NRF1 AKT2 GAPDH-1 AKT3 GSK3B PDE4D-1 TFAM-1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260710%WP437%HOMO SAPIENS EGF EGFR signaling FOXO1-1 CBL CFL1 PCNA STAT5A GRB10 STAT5B PTPN11 SH3GL3 STMN1 PIAS3 AP2A1 PLD1 RAF1 CBLC CBLB TNK2 RPS6KA3 PTK6 RPS6KA2 SYNJ1 CAMK2A INPP5D PLCG1 ITCH ATF1 JUND MAP4K1 CRKL FOSB STAM RPS6KA1 PTEN MAP3K2 MEF2A RAC1 MAP3K3 MEF2D AP2B1 PXDN PEBP1 PLCE1 ELK4 RALBP1-1 RPS6KA5 RALA-1 STAT3 PLD2 RALGDS GAB1 CREB1 DNM1 HGS PIK3R1 EIF4EBP1 PRKCD PAK1 MAPK1 EPS15 VAV1 USP8 EPN1 NEDD4 KRAS NCOA3 MTOR RPS6KB1 JAK1 ELK1 ERRFI1 PRKCI NDUFA13 PTPRR FOXO4 PRKCZ E2F1 FOS EGF STAT1 SPRY2 EGFR MAPK8 RIN1 RAB5A IQGAP1 PTK2B JUN MAPK14 AP2M1 RICTOR MAP3K4 AKT1 AP2S1 PTPN5 ARHGEF1 ARF6 PIK3R2 RAP1A STXBP1 MAP2K5 CAV2 CAV1 BRAF PTK2 GRB2 JAK2 MEF2C PIK3C2B HRAS VAV3 SOS2 PDPK1 MAPK9 RASA1 ERBB2 PRKCB VAV2 MAP3K1 SOS1 CRK ROCK1 SRC MAPK7 MAP2K2;MAP2K1 RALB CSK SP1 CDC42 MAPK4 NCK2 ABL1 BCAR1 SHC1-1 GJA1 NCK1 USP6NL PRKCA NOS3 INPPL1 EPS8 STAMBP STAM2 ATXN2 IQSEC1 SH3KBP1 EPS15L1 PLSCR1 ASAP1 REPS2 LIMK2 PTPN12 SH3GL2 ABI1 GAB2 DOK2 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260710%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AVPR1B ADAM17 AGTR1 IL26 SIGNALING%WIKIPATHWAYS_20260710%WP5347%HOMO SAPIENS IL26 signaling MPO IL17A MMP1 SOCS3 MAPK8 TNF MAPK9 ICAM1 IL10 JUN PIK3CA STAT3 MAPK14 IL10RB IL6 EPHA3 RELA NFATC1 BAX IL20RA CSF2 MAPK1 ACTA2 MAPK3 AKT1 SMAD2;SMAD3 CASP3 JAK1 CXCL8 IL33 CCL20 MMP9 CTSK IL1B TNFSF11 JAK2 IL26 RORC DCSTAMP DEFB4A;DEFB4B NFKBIA ATP6V0D2 DDIT3 STAT1 TYK2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260710%WP3877%HOMO SAPIENS MYD88 distinct input output pathway UBE2V1 TLR1 TLR7 MYD88 TLR9 TLR8 JUN IL1A TLR6 TLR2 IRAK1 NFKB1 TIFA UBE2N TLR10 TLR5 TRAF6 TLR4 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members AXIN1 TNK2 PLK1 DVL1 DVL2 DVL3 PARP1 SKP1 TNK1 RBX1 APC CUL1 CTNNB1 BTRC PARP10 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260710%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CMTR2 TP53 CEBPA MAGI1 BRD1 ATRX INSRR MORF4L1-2 FGF16 IL17RD CTBP1 FOXP2 KMT2C KAT6A CREBBP CNTN6 UHRF1 MGA MYCBP-1 ERBIN H2AC16;H2AC11 EP300 H1-4 BCOR KANSL1 NFIB MYC RAF1 FBXW7 AKT1 FOXO3 CHEK2 TLK1 CHEK1 MYB MAX SMARCE1 PRKDC MAGI2 ATM FGFR4 MYCN PTEN BCORL1 SMARCA2 BRCA1 ARID1A HRAS NOTCH1 NCOR1 KDM6B ERBB2 PIK3CA SMC1A SETD2 MAP2K2;MAP2K1 ARID5B ARID4B KDM6A NSD1 DTX4 MAML3 SRCAP JMJD1C MYBL1 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome CUL3 CD160 SKI HES5 INTS4 UBE2J2 PANK4 INTS11 INTS13 INTS14 IFIH1 DLL1 INTS10 CDK11A;CDK11B DKK3 GDE1 TMEM52 GRIK2 NOC2L OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK OR4F5;OR4F17;OR4F4 SSU72 PEX2 ACAP3 RER1 DVL1 SCNN1D SMAD2;SMAD3 CPTP MMP23B PEX5 ARF6 MXRA8 VWA1 AURKAIP1 BTLA PERM1 MRPL20 KLHL17 TNFSF4 MEPCE RBX1 LRP4 SMAD4 PARD6B PUSL1 TAS1R3 NADK HES4 TNFSF18 GABRD CFAP74 B3GALT6 MIB2 PEX10 PEX12 RNF223 VEGFA MORN1 KRT17 FNDC10 ANKRD65 INTS9 SLC35E2B C1orf159 TGFB1 ATAD3A;ATAD3B C1QTNF12 PHKG2 ESR1 DLST HSPA8 MCM2 GNB1 VTN ISG15 ELAVL1 TNFRSF4 IFIT1 AGRN TNFRSF14 PRKCZ TRAF2 COMMD1 TNFRSF18 CALML6 TRIM25 PLCH2 TRAF5 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260710%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome GRIA1 DHX9 GAMT GRIA3 SST GRIA4 CEBPD APOC2 RPS6 EZH2 CSRP1 TAP1 FGF4 IGF1R GABRR2 DLX5 SMC3 AKT1 SP3 GPRIN1 MYT1 FOXG1 FUT8 CAMK2A MECP2 OPRK1 CNP BCL6 MEF2C MAG FUS FGF2 SIN3A GRID1 FKBP5 PTEN GAD1 PSIP1 UBE3A CTCF RBFOX1 NCOR1 TET3 ARHGEF26 DLX6 NREP MPP1 PRPF38A POU4F1 HNRNPF CDON CREB1 YBX1 HNRNPH1 TET2 BDNF IGF1 GRIN1 SP1 SGK1-1 NF1 TAF1 TET1 MTOR REST MBP IGF2 POU3F2 E2F1 FGF3 HDAC1 FGF5 TARDBP HEME BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 FECH UROD UROS ALAS1 PPOX CPOX HMBS ALAD METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260710%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX5 ALOX15 ALOX12 PTGS2-2 FADS2 FADS1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260710%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260710%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL3L RPS25 RPS27 RPS29 RPL27A RPS20 FAU RPL10A RPS21 RPS24 RPS23 RPS6 RPS27A RPL13A-1 RPS6KA3 RPS6KA6 RPS6KA2 RPL18A RPS11 RPL38 RPS6KA1 RPS6KB2 RPL11 RPL4 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPS19 RPS18 RPL7 RPL37A-1 RPL35 RPL36-1 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPL27 UBA52 RPS6KB1 RPS9 RPL26 RPS7 RPL21 RPS8 RPL23 RPS5 RPL22 RPS3A RPSA RPL24 RPL5-1 RPL29 RPL28 RPL10;RPL10L-1 MRPL19 RPL30 RPS15A RPL14 RPS3 RPLP2 RPL13 RPS2 RPL12-1 RPL18 RPL17 RPL19 RPL35A RPL23A TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation STAT6 MEF2B;BORCS8-MEF2B TLR1 SLAMF1 TLR7 IL21R TLR9 SPIB TLR8 POU2AF1 ID3 CDKN2A STAT3 TLR6 TLR3 EZH2 TLR2 SPI1 IL6 CCND3 CCND2 TCF4 MYC IRF4 BCL2L1 IRF8 SYK POU2F2 LOC102723996;ICOSLG BCR LYN CD79A CDKN1A NFKB1 CD40 BCL6 E2F1 CD79B CDKN1B MEF2C TNFRSF13C IL4R TLR10 TLR5 TLR4 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260710%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1H4 ABCB11 SULT2A1-4 SLC51A BAAT SLC51B VDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 ABCC4 CYP7A1 ABCC2 ABCB1 SLC10A1 NR1I2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NR1I3 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260710%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD247 CD3E IL2 CD28 BCL2 CD86 CD3D SPN CD80 CD27 CD3G CANCER PATHWAYS%WIKIPATHWAYS_20260710%WP5434%HOMO SAPIENS Cancer pathways KEAP1 TERT CCND1 CDH1 CUL2 EP300 JAG2 LPAR1 DLL1 BIRC7 DLL3 CCNE1 RAF1 ELOC-1 CCDC6 RASGRP1 HIF1A HMOX1 RET GLI1 GLI3 CAMK2A GLI2 GNA11 PTGS2-2 NFE2L2 ELOB SLC2A1 SMO RARA RAC1 RARB RPS6KA5 IL15 STAT3 GNAQ IL6R NCOA1 RELA PPARD IL6ST MAPK1 MAPK3 EPOR MTOR NCOA3 TGFA LPAR2 RPS6KB1 TGFBR1-1 LPAR3 IL12RB1 LPAR4 GNG10 JAK1 RB1 IL12RB2 CDKN1A IGF2 FASLG GNG13 ELK1 LPAR5 LPAR6 TGFBR2 CCNA2-1 PRKCG XIAP MSH6 PDGFRA HSP90AA1 MMP2 PLCG2 TRAF2 FOS CDKN2B EGF STAT1 CDK6 IFNG CDK4 TRAF6 TXNRD3 TRAF5 TP53 FGFR2 EGFR MAPK8 BCL2L11 CTBP1 PGF BAK1 COL4A6 BID JUN CDKN2A IL2 IL6 GNB2 BCL2 FAS GNB4 GNB3 BAX BCL2L1 GNB5 HSP90AB1 LAMC3 LAMC2 LAMA1 LAMA3 GNG2 GNG5 AGT GNG4 GNG8 CCDC42 HGF LAMB3 CCNE2 LAMB4 MET LAMB1 TGFB2 STAT4 TGFB3 VEGFA CDK2 ADCY4 ADCY2 RXRA PRKACB-1 PRKCB TGFB1 MITF IL4 IL5 PLCB3 IL12A PLCB4 ADCY9 ITGB1 ROCK1 PLCB1 ROCK2 PLCB2 CSF3R EPO IL5RA ETS1 KNG1 IL13RA1 ABL1 BDKRB2 BDKRB1 CSF1R CAMK2G PRKCA NOTCH2 CSF2RB CSF2RA AGTR1 FZD3 RHOA IL7R HEY2 CTNNB1 JAK3 IL4R AXIN2 IL3RA CEBPA CBL WNT8A IL2RG HES1 STAT6 HES5 STAT5A STAT5B IL2RA IL2RB AR F2R PLD1 NQO1 TXNRD2 TXNRD1 F2RL3 APAF1 GADD45A TRAF1 TRAF3 SKP2 SKP1 MGST3 MGST1 CXCL8 MGST2 IL12B IL13 CUL1 VEGFB VEGFC VEGFD GSTM4 CXCL12 GSTM3 IL23A GSTA3;GSTA1 APPL1 ZBTB17 DCC GADD45B GSTA3;GSTA5;GSTA1;GSTA2 GADD45G POLK RALBP1-1 RALA-1 PLD2 RALGDS CCNA1 COL4A4 COL4A3 COL4A5 LAMA5 LRP6 GSTO2 JAG1 E2F2 GSTO1 E2F3 LAMB2 GSTT2B;GSTT2 GSTP1 CALML6 CALML3 CALML4 RXRB RASSF1 F2 RASSF5 GSTM1;GSTM2-1 RXRG VHL RASGRP2 FGFR1 GSTA4 RASGRP4 RASGRP3 ITGA2B ARAF AKT2 AKT3 AKT1 TPR PIK3R2 BRCA2 RUNX1T1 RAD51 BRAF ZBTB16 PTK2 GRB2 RAC3 ITGAV FH HRAS NOS2 EDN1 CAMK2D ITGA3 PDGFRB FZD5 ITGA2 FZD4 FZD2 ITGA6 FLT4 SOS1 CRK TPM3 MAP2K2;MAP2K1 MST1 MAPK10 KIT FGFR3 EGLN1 FN1 LAMA4 LAMC1 PAX8 COL4A2 COL4A1 FRAT2 ESR2 HEY1 APC2 HEYL EPAS1 GSK3B PTEN PIK3CD RPS6KB2 PIK3CB PIK3CA CAMK2B PIK3R3 PIK3R1 NRAS CTBP2 IL7 KRAS HDAC2 BIRC5 HDAC1 FZD6 FZD9 WNT9B NTRK1 FZD10 CREBBP WNT9A TFG DAPK2 DAPK3 MECOM WNT8B NKX3-1 PLEKHG5 TRAF4 CKS1B CCND3 ARHGEF11 CCND2 ARHGEF12 DAPK1-1 MYC EDNRA EDNRB WNT5B WNT5A MSH2 MDM2-2 TCF7 WNT6 DVL1 GNA13 SMAD2;SMAD3 DVL2 GNA12 DVL3 ARHGEF1 PMAIP1 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A SMAD4 WNT3A NFKB1 NFKB2 WNT2B CDKN1B MSH3 BBC3 AXIN1 WNT16 SOS2 LEF1 MAPK9 WNT11 ERBB2 NCOA4 TCF7L2 TCF7L1 BAD WNT7B WNT7A APC PTGER4 CHUK PTGER1 ESR1 PTGER2 GNAS-1 GNGT1 IKBKB PTGER3 PRKACA-1 MLH1 RALB SP1 GNB1 IKBKG EML4 ADCY3 ADCY1 NFKBIA ADCY8 ADCY7 LAMA2 ADCY6 FOXO1-1 ADCY5 CTNNA1 CTNNA3 CTNNA2 FZD1 JUP SPI1 IFNAR2 FZD7 IFNGR1 FZD8 STAT2 IFNGR2 FGF1 IFNAR1 IGF1R BCR MAX DDB2 NOTCH3 RBX1 NOTCH4 PDGFB DLL4 PLCG1 KITLG CRKL FGFR4 KLK3;KLK2 MMP1 ARNT GNAI3 CXCR4 GNAI1 GNAI2 E2F1 RUNX1 ALK PDGFA SHH FLT3LG ARNT2 CASP9 CYCS-1 CASP7 CASP8 CASP3 FADD EGLN2 BIRC3 MMP3 EGLN3 BIRC2 JAK2 NOTCH1 LRP5 PML HHIP PTCH2 HSP90B1 KIF7 IGF1 BMP4 IL3 BMP2 PIM1 PIM2 PTCH1 FLT3 PPARG COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260710%WP2636%HOMO SAPIENS Common pathways underlying drug addiction GRIA1 GRIA2 GRM1 PRKACB-1 DRD1 GRIA3 GRIA4 DRD4 PRKCB ACTC1;ACTG2 CREB1 GRIN2A ARAF GNAS-1 MAP2K2;MAP2K1 PRKACA-1 RAF1 MAPK1 GRIN1 ACTG1 MAPK3 GNAI1 GRM5 PPP1CA PPP1CB PPP1CC CAMK4 RAP1B RAP1A PRKCA PPP1R1A CAMK2A GJB1 DRD2 PRKCG CALM1 ACTB-1 ADCY1 ADCY8 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260710%WP5546%HOMO SAPIENS 22q11 2 distal CNV CBL CUL2 RPS6 SDF2L1 ELOC-1 BCR CHEK1 CD79A RBX1 CAMK2A LRP4 RPS11 IQUB ROPN1L CD79B ELOB RSPH6A DNAJB13 NME5 UBE3A DYDC1 SF3B4 RSPH9 CDC16 RSPH3 SNW1 PTPA RPS15 RPS14 PAK1 RPS17 MAPK1 RPS16 RPS19 RPS18 ARIH1 NEDD4 RPS10 RPS13 RPS12 RPS9 RPS7 CAMK4 RPS8 CAMK1 RPS5 PPIB PRKN RPSA RPS15A RPS3 RPS2 PDIA2 TP53 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RNF19B PPIL1-1 EFTUD2 VPREB1 SNRPD2 SNRPD1 CWC22 SRRM2 ZNF280D;ZNF280A SNRPD3 CRNKL1 PDIA4 MDM2-2 RAB36 ERP29 RPS27A PPIE SNRNP200 UBA6 CABP1 AK8 CWC15 TDRD3 TOP3B CCDC116 BUD31 SNRPF PLRG1 YDJC RBM22 PPM1F SNRPB RNF113A PRAME RILP UGGT1 PPIL2 CDC5L PRPF8 YPEL1 XBP1 PPIL4 SNRPE-2 HSPA5 UBA1 PPIL6 CANX ATF6 XAB2 DHX16 GNAZ CALR-1 HSP90B1 SNRPA1 SF3B5 SF3B2 PAK2 AQR SF3B3 DNAJB11 SNRPB2 SOX9 SNRPG-2 SF3B1 SF3A3 SF3A1 SF3A2 SNRNP40 IGLL5;IGLL1 PHF5A HYOU1 RACK1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260710%WP3924%HOMO SAPIENS Hfe effect on hepcidin production SMAD7 HFE ID1 HAMP TMPRSS6 HJV BMP6 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260710%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 ACAT1 ACAT2 OXCT1-1 HMGCS1-1 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260710%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling RAC1 TNFRSF12A MAPK8 TNF MAPK9 JUN MAPK14 MAP3K14 CHUK RELA IKBKB MAP3K7 TRIM63 RAF1 MAPK1 AKT2 MAPK3 AKT1 TRAF1 CASP7 CASP8 TRAF3 CASP3 RIPK1 FADD BIRC3 BIRC2 NFKB1 NFKB2 RELB NFKBIB TRAF2 CTNNB1 NFKBIA HDAC1 GSK3B TRAF5 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260710%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism HMGCR MTTP NPC1L1 IDI1 MVK LDLR APOA1 FABP2 MSMO1 DGAT1 HSD17B7 ACAT2 APOA4 TM7SF2 HMGCS1-1 EBP NSDHL CD36 PMVK SC5D SLC27A4 LBR FDFT1 FDPS SAR1B APOB DHCR24 LSS SQLE MVD DHCR7 ABCA1 MGAT1 ABCG8 ABCG5 CYP51A1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260710%WP699%HOMO SAPIENS Aflatoxin B1 metabolism EPHX1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GSTM1;GSTM2-1 AKR7A2 AKR7A3 CYP2A13;CYP2A6;CYP2A7-1 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer TP53 APAF1 CASP9 CHEK2 SERPINE1 CASP8 SESN3 CASP3 PMAIP1 BID DDB2 BAX ATM SIAH1 SHISA5 CYS1 EI24-1 ZMAT3 PERP MDM2-2 BBC3 PTEN TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260710%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients ATG16L1 NEDD4 TGFBR2 SMAD2;SMAD3 TGFBR1-1 PMEPA1 LDLRAD4 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260710%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development TP53 RBBP4 FOXO1-1 HES1 HES5 CCND1 TSC1 CSNK1A1 DLL1 CASP9 CASP3 TSC2 GLI1 DYRK1A RBL2 E2F4-1 AMPH SMARCB1 CDKN1B FGF2 DEPTOR NEUROG2 GSK3B HIP1 RPTOR LIN54 LIN52 RAD54L2 LIN37 NOTCH1 TFAP4 H3-3A DCAF7 EIF2B5 SIRT1 CREB1 DNM1 CRY2 RBL1 TFDP1 TFDP2 NFATC1 LATS2 E2F5 MTOR GMNN REST LIN9 MLST8 APH1A BACE1 PSENEN AKT1S1 APP NCSTN CDK6 DNER MAPT CDK4 PSEN1 SPRY2 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260710%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing RNASEH2C RNASEH2B RNASEH2A RNASET2 IFNB1-4 SAMHD1 RNASEL ADAR DDX58 CGAS IFIH1 TREX1 OAS1 IRF3 MAVS STING1 CILIOPATHIES%WIKIPATHWAYS_20260710%WP4803%HOMO SAPIENS Ciliopathies ZMYND10 ADCY6 KIZ CFAP53 GAS8 CILK1 CNGB1 KATNIP CCDC103 DNAH6 SPAG1 PKD1L1 RAB23 POC1A POC1B RAB28 DNAI1 TUB USP9X WDR19 PCARE SCLT1 RPGRIP1 RP1L1 TTLL5 HYLS1 CCDC65 ATXN10 TRIM32 GLI3 GLI2 DNAJB13 SMO DYNC2I2 DYNC2I1 TRAF3IP1 RSPH9 IFT172 RSPH4A RSPH3 WDR35 IFT80 RSPH1 IFT81 INTU NEK9 BBS2 BBS1 BBIP1 CEP19 MKS1 BBS9 BBS7 BBS5 ALMS1 IFT140 OCRL ZNF423 CENPF DYNLT2B BBS4 PKD2 PKD1 TTC8 TULP1 LZTFL1 PIK3R4 GPR161 ANKS6 PDE6D SPATA7 NEK8 NME7 KIAA0753 IFT122 OFD1-1 IFT27 CEP164 CEP120 CRX TCTN3 TCTN2 CSPP1 TCTN1 ODAD1 CC2D2A GALNT11 IFT52 ODAD3 TMEM138 IFT57 ODAD2 RP2 ODAD4 CEP290 TMEM216 MCIDAS CEP104 IQCB1 TBC1D32 ARL3 NEK1 NEK2 ARL13B EVC2 DNAAF3 TMEM67 DNAAF2 INPP5E IFT43 DNAAF1 DNAAF6 PIBF1 DNAAF5 KIF7 DNAAF4 EVC CFAP410 CPLANE1 CCDC40 RP1-2 TMEM231 FAM161A ZIC2 MAK TMEM17 CFAP298;CFAP298-TCP10L NPHP3 KIAA0586 WDPCP TMEM237 CCNQ UNC119 CCNO B9D1 ARL6 CEP41 AK7 B9D2 TTBK2 GLIS2 PKHD1 CEP78 DYNC2H1 PLK4 DNAH11 AHI1 LCA5 DCDC2 C8orf37 ARL2BP CEP83 XPNPEP3 DYNC2LI1 DRC1 CLUAP1 DNAL1 C2CD3 FLCN TMEM107 HYDIN INVS CNGA1 NPHP1 TAPT1 RPGRIP1L CCDC39 CFAP52 DNAI2 TTC21B MKKS DDX59 POMGNT1 TOPORS BBS10 BBS12 NME9 EFHC1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260710%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1C CHRNB4 CACNA1G SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260710%WP4496%HOMO SAPIENS Signal transduction through IL1R MAPK8 IRAK3 TNF MAP2K6 IFNB1-4 ECSIT JUN TGFB1 MAP3K1 MAPK14 IRAK1 MAP3K14 IL1RN IL6 CHUK RELA IKBKB MAP3K7 IL1RAP TAB1 IL1R1 MYD88 IL1A IL1B NFKB1 MAP2K3 IRAK2 TGFB2 TGFB3 NFKBIA TOLLIP TRAF6 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260710%WP1971%HOMO SAPIENS Integrated cancer pathway TP53 MMP1 BRCA1 PLK1 BACH1 ATR BAD CDC25A BCL2 BAX MYC MDM2-2 MSH2 AKT1 CASP9 CHEK2 SMAD2;SMAD3 CDK1 CASP8 CASP3 CHEK1 MRE11 JAK1 RB1 CDC25B CDKN1A RAD50 MAP3K5 BARD1 ATF1 MSH6 ATM E2F1 CDKN1B CDKN2B BLM POU2F1 STAT1 BBC3 CDK4 CDK2 PTEN NOXA1 NRF2 ARE REGULATION%WIKIPATHWAYS_20260710%WP4357%HOMO SAPIENS NRF2 ARE regulation CUL3 MAPK8 GSTA3;GSTA5;GSTA1;GSTA2 KEAP1 HMOX1 FYN PGAM5 PRKCA PIK3CA YES1 RBX1 INSR EPHB2 MAF SRC NFE2L2 SLC7A11 NQO1 AIMP2 GCLC GSK3B GCLM CEBPB MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260710%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 ID1 USP1 CDKN1A ID2-1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260710%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation FGF9 PTHLH MAPK14 IHH MAPK12 MAPK13 PTH1R ATG5 MAPK11 RBL1 FGF18 MAP2K2;MAP2K1 RAF1 MAPK1 BMP4 PPP2CB;PPP2CA NPR2 MAPK3 BMP2 SOX9 CDKN1A THRA CNP FGFR3 STAT1 SNAI1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260710%WP410%HOMO SAPIENS Exercise induced circadian regulation PSMA4 CRY1 CLOCK HERPUD1 IDI1 KLF9 ARNTL NCOA4 PER2 H2BC15;H2BC3;H2BC11;H2BC12 CRY2 QKI NR1D2 HLA-DMA DNAJA1-1 EIF4G2 HSPA8 VAPA PPP2CB;PPP2CA NCKAP1 CEBPB PER1 DAZAP2 BTG1 AZIN1-2 SUMO1 PURA UGP2 STBD1 SUMO3 TOB1 ERC2 RBPMS ZFR SF3A3 G0S2 CLDN5 MYF6 PPP1R3C ETV6 GSTP1 GFRA1 CBX3-1 GSTM3 PIGF TAB2 UCP3 TUBB3;TUBB6 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260710%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte CEBPA ADIPOQ SMAD1 SMAD9 PRDM16 SMAD5 BMP4 CEBPB PPARGC1B BMP2 SLC7A10 PPARGC1A LEP PLAC8 CEBPG HSPB7 HOXC9 HOXC8 MPZL2 EBF3;EBF1 CIDEA BMP7 ZIC1 ZNF423 PPARG FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5102%HOMO SAPIENS Familial partial lipodystrophy CEBPA GATA3 LMNA BANF1 LPL MAPK9 SREBF1 STAT5B FABP4 KLF9 GATA2 PIK3CA PPARA INS;INS-IGF2 PLIN1 MGLL AKT2 LMNB1 FNTA ICMT LIPE KLF2 PNPLA2 CIDEA PRRX1 CIDEC ZMPSTE24 KLF5 LMNB2 PPARG HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260710%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system GRIA1 GRIA2 EP300 PROM1 CYBB DLG2 FOXP3 SQSTM1 DCTN1 HIF1A CDC20 MDH1 SOD1 RAD23B KALRN ATXN3 UBD CCDC141 HSPA4 CNOT6 ERG NEDD9 MIIP ELP1 GSK3B ARID3A MAP1LC3A SNCAIP GARS1 RAC1 STUB1 NDUFV1 G3BP1 HSPB1 CSNK2B MYH9 BDNF APOE DNAJA1-1 HSPA8 MAPK1 SIRT2 MAPK3 BBIP1 DLG4 SGK1-1 OPTN-1 HDAC6 CSNK2A2 ELP3 SNCA MYD88 VIM AURKA PRKN XRCC6 ATP13A2 MAP3K5 RHOT1 PRKCZ HSP90AA1 SGK3;C8orf44-SGK3 BIRC5 ITIH4 TARDBP SMAD7 DYNC1I2 EGFR MAPK8 EP400 PTK2B VHL KAT5 CFTR HSF1 PARK7 BCL2 BAX MAP1B PRDX1 SHH AKT1 PPP1CA SMAD2;SMAD3 PXN GSK3A ACTR1A HTT FUS POU5F1;POU5F1B HDAC9 GRK2 APC SP1 PRKCE MIF ISG15 TUBA1C HDAC11 VCP-1 TUBA3E;TUBA3C-1 NR3C1 TUBA4A CTTN MAPRE1-1 PRDX2 TUBB4A;TUBB;TUBB8B;TUBB8 TPPP CTNNB1 MAPT TUBB3;TUBB6 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBE2L6 UCHL1 SEPTIN5 PINK1 GPR37 UBE2G1 UBE2G2 SYT11 UBE2J2 MAPK14 PARK7 MAPK12 MAPK13 MAPK11 CCNE1 UBB;UBC DDC LRRK2 APAF1 SLC6A3 CASP9 CYCS-1 CASP7 HTRA2 CASP3 SNCA UBE2J1 PRKN CASP6 ATXN2 TH CCNE2 UBA7 UBA1 CASP2 SNCAIP EPRS1 ID SIGNALING%WIKIPATHWAYS_20260710%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 SREBF1 ELK4 RB1 ID3 RBL2 ID2-1 ELK1 PAX2 RBL1 ID1 PAX8 CCNE1 MYOD1 CDK2 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260710%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL31RA IL2RG IL13RA1 IL1RL1 STAT6 FCER1G FCER1A DEFB103A;DEFB103B MS4A2 IL25 STAT3 IL4 IL33 IL5 IL13 CRLF2 OSMR JAK3 IL4R TSLP TYK2 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260710%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAG1 LEPR ADIPOR2 LEP ACACA CPT1A PRKAB1 ADIPOR1 ADIPOQ PRKAA1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260710%WP400%HOMO SAPIENS p38 MAPK signaling RAC1 HRAS MEF2D RASGRF1 RPS6KA5 MAP2K6 HMGN1 MAP3K1 MAPK14 MAPKAPK5 CREB1 MAPKAPK2 HSPB1 MYC MAP3K7 CDC42 MAP3K9 TRADD MKNK1 TGFBR1-1 SHC1-1 RIPK1 ATF2 MAX ELK1 DAXX PLA2G4A MAP3K5 GRB2 MAP2K4 TGFB2 SMIM40 TRAF2 DDIT3 STAT1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260710%WP3287%HOMO SAPIENS Overview of nanoparticle effects PIK3CD FN1 TNF HMOX1 LAMA3 PTGS1 CXCL8 NFRKB ITGAD PTK2 IL6 CCND3 BCL2 PTGS2-2 BAX CDH3 COL4A1 AKT3 CRP AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260710%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma TP53 BECN1 KRAS PINK1 TFEB VMP1 SHOC2 HMGB1-1 STAT3 MITF IPO8 PRKN MAP1LC3B2;MAP1LC3B-1 TFE3 ATG7 NFKB1 NFE2L2 SQSTM1 AGER MDM2-2 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260710%WP3929%HOMO SAPIENS Chemokine signaling ADCY6 ADCY5 CX3CR1 STAT5B STAT2 CCL23;CCL15 CCR6 RAF1 LYN CCL11 CCL4L2;CCL4L1;CCL4 SHC2 FGR CXCR2 CXCL5;CXCL6 CCL22 CXCL11 GRK6 CCL21 CCL20 ITK CXCL2;CXCL3;CXCL1-1 CCL27 CRKL CCL26 CXCL12 CXCL13 GSK3B CCL28 CCR9 PIK3CD RAC1 PF4;PF4V1-1 PIK3CB CCL3L1;CCL3L3;CCL3;CCL18 PIK3CA STAT3 PREX1 TIAM2 PARD3 ELMO1 PIK3R3 DOCK2 PIK3R1 PRKX NRAS PRKCD RELA HCK GNAI3 PAK1 CCL5 CXCR4 MAPK1 VAV1 CXCL10 MAPK3 GNAI1 GNAI2 KRAS CXCR3 CCR7 GNG10 CCR4 CXCL9 CCR3 CCR2 CCR1 GNG13 PRKCZ NFKBIB STAT1 CCL1 TIAM1 SHC4 PTK2B RASGRP2 GNB2 GNB4 GNB3 GNB5 CCR10 AKT2 XCR1 AKT3 AKT1 XCL1;XCL2 FOXO3 CCL17 PIK3R5 GRK1 PPBP SHC3 PXN PIK3R2 RAP1B GNG2 RAP1A GNG5 GNG4 GNG8 BRAF PTK2 NFKB1 GRB2 JAK2 CX3CL1 PIK3CG CCR8 HRAS ADCY4 VAV3 ADCY2 ARRB1 SOS2 ARRB2 CXCR5 PRKACB-1 CXCR6 CCL19 PRKCB VAV2 CCL25 CCL24 GRK2 PLCB3 PLCB4 ADCY9 SOS1 CRK ROCK1 CHUK PLCB1 ROCK2 PLCB2 GRK5 GRK4 GNGT1 WAS MAP2K2;MAP2K1 IKBKB CSK WASL GNB1 IKBKG CDC42 CXCL14 BCAR1 SHC1-1 NCF1 ADCY3 NFKBIA JAK3 ADCY1 ADCY8 ADCY7 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260710%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress TP53 FOXO1-1 CUL3 MAPK8 PINK1 KEAP1 TNF ICAM1 MAPK14 TSC1 IL6 BCL2 CCNE1 BCL2L1 NQO1 SOD2 MDM2-2 NOX1 AKT1 HMOX1 CHEK1 CXCL8 NFKB1 PTGS2-2 NFE2L2 NRF1 CDK2 PTEN CAT NOS2 RPS6KA5 ATR PIK3CA SIRT1 CREB1 IPCEF1 PIP-1 GSX1 IKBKB IKBKG RHEB MTOR ATF2 IL1A CDKN1A MAP3K5 MAP2K3 MAP2K4 FOS CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260710%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2A SRF MEF2D MEF2B;BORCS8-MEF2B HDAC5 LEFTY2;LEFTY1 STAT3 ID2-1 TLX1 EZH2 SOX2 TLX2 TLX3 MYOD1 MEF2C KLF4 RUNX2 PAX7 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260710%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis PPARGC1A HMGCR MTOR SCD LDLR SREBF1 ABCA1 PPARA HMGCS1-1 PRKAA1 SIRT1 MED15 FASN SIRT6 NR1H3 SREBF2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2879%HOMO SAPIENS Farnesoid X receptor pathway PPARGC1A NR1H4 ABCB11 RXRA SULT2A1-4 BAAT UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP8B1 SLC27A5 SLCO2B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IP6K3 CYP7A1 FGF19 IRS2 NR0B2 FKBP5 SLC10A1 ABCB4 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome CLTC USF1 CFL1 HDAC3 PCNA EIF2A ATF4 CDKN1C DLD ULK1 SQSTM1 OGDH RFC5 ACACA RFC2 PKLR CLDN5 NRG1 MYO1C HOXC8 LAT2 LIMK1 ERCC6 UBE2L6 CLASP1 CHTF18 TSG101 SNAP25 ABHD11 UBE2E3 CLIP2 BRD4 CLDN3 DNAJC30 FKBP6 VPS28 ATPAF2-2 FBLN2 MAPK3 FBLN5 TBL2 EIF4H GTF2IRD1 BCL7B HDAC6 BUD23 VPS9D1 VPS37C VPS37D VPS37A VPS37B METTL27 ATPAF1 RB1 MVB12A CLASP2 TRIM74;TRIM73;TRIM50 TMEM270 HDAC2 CLDN4 FZD9 FBN1 NUP62 HSPA2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B FAS MYC VAMP2 ATP5PB MYBBP1A DDX21 ATP5F1D ATP5PO WNT2 STX1A GRB2 BTK EIF2AK3 UBIAD1 BECN1 ACACB DLST UBE2E1 CLDN1 BAZ1B PRKG1 SF3B1 SMARCA5 DEK GRIP1 CTNNB1 GAPDH-1 GTF2I ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2853%HOMO SAPIENS Endoderm differentiation FOXO1-1 WNT8A BPTF LAMC1 C1QBP TCF4 DUSP2 SOX7 CER1 ACACA RARG TBX21 GLI2 FOXA1 SIAH2 CUL4B ZBTB17 PIAS1 ELK4 CEBPZ NLK CTBP2 ELAVL1 PABPC1;PABPC3 MAD2L2 FOXH1 WWC1 NOG SFMBT1 CDYL RFX7 RAB38 CTR9 MAP2K3 PRDM14 RTF1 FOXN3 DUSP4 DAB2 SP4 PAF1 TAF4B ONECUT1 HOXC11 STAT1 CDC73 HNF1B HHEX PAX9 BTAF1 LEO1 NKX2-1 KDM4A TNRC6C CAND1 TAF5 LRPPRC EZH2 NAA15 OTX2 TCF7 SMAD2;SMAD3 GDF3 BMPR1A SFRP1 WNT3 NME1 SOX21 SMAD4 SOX2 SOX17 NODAL SESN1 CEP250 DIP2A EOMES WDHD1 ZNF281 DKK1 EMSY WDFY2 BCORL1 TOX GATA6 POU5F1;POU5F1B PTHLH NOTCH1 MBTD1 VAV3 EPB41L5 UBR5 LEF1 GATA4 ATP8B2 TGFB1 PBX3 ZFHX4 TCF7L1 TRERF1 HPRT1 PBX1 EXT1 NANOG;NANOGP8 APC NABP2 PLCH1 TRIM71 NCAPG2 PHF6 TRIM5 ZIC3 JARID2 SLC2A12 TET1 HOXA1 PARP8 TOX3 DDAH1 NR3C1 AEBP2 MTF2 AHDC1 DNMT3B ASCC3 BMP7 ZNF462 LHX1 ELP4 CRTC1 GRHL2 RGS10 MIXL1 CTNNB1 FOXA2 APP PAX3 DUSP5 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260710%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 TMPRSS2 MAS1 ACE AGT AGTR1 REN LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer FZD6 FZD9 CTBP1 FZD10 RYK-1 CCND1 ROR1 JUN TPTEP2-CSNK1E;CSNK1E ROR2 FZD1 EZH2 CSNK1A1 FZD7 CCND3 FZD8 CCND2 SFRP4 PLAU MYC MAP3K7 CER1 WNT5B CTNNBIP1 WNT5A KREMEN1 SENP2 TCF7 SFRP5 CXXC4 NKD1 NKD2 WNT6 DVL1 NOTUM DVL2 DVL3 WNT1 PORCN WNT2 TFAP2A SFRP1 WNT3 FRAT2 WNT4 WNT10B WNT10A SOX17 APC2 WNT3A WIF1 DKK4 SOST FOSL1 SERPINF1 WNT2B DKK2 DKK1 GSK3B AXIN1 WNT16 HNRNPK LEF1 LRP5 WNT11 FZD5 TCF7L2 FZD2 TCF7L1 SFRP2 WNT7B WNT7A NLK APC MACROH2A2 CTBP2 CSNK2B LRP6 ATF3 CSNK2A2 CDK8 CSNK2A1;CSNK2A3 FZD3 RUVBL1 HNRNPU CTNNB1 AXIN2 CDK6 CHD8 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260710%WP5234%HOMO SAPIENS Bardet Biedl syndrome CILK1 DYNLT2B SCAPER CNGB1 BBS4 PKD2 PKD1L1 PKD1 RAB23 USP9X WDR19 TTC8 PCARE SCLT1 TRIM32 LZTFL1 GPR161 PDE6D NEK8 GLI3 GLI2 IFT122 FUZ IFT27 SMO CEP164 CRX DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 IFT52 IFT57 ARNTL WDR35 RP2 CEP290 IFT80 TMEM216 IQCB1 CEP104 ARL3 NEK1 ARL13B EVC2 IFT81 TMEM67 IFT43 INPP5E KIF7 EFHC2 EVC CFAP410 ZIC2 MAK NPHP3 BBS2 WDPCP BBS1 IFT74 BBIP1 ARL6 CEP41 PKHD1 PTCH1 MKS1 DYNC2H1 LCA5 DCDC2 BBS9 C8orf37 DYNC2LI1 CLUAP1 BBS7 BBS5 FLCN TMEM107 INVS CNGA1 IFT140 OCRL MKKS TTC21B BBS10 BBS12 EFHC1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260710%WP1434%HOMO SAPIENS Osteopontin signaling ITGAV MMP9 MAP3K14 NFKB1 CHUK RELA PLAU MAP2K2;MAP2K1 IKBKB SPP1 MAPK1 ITGB3 MAPK3 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SFN ZP3;POMZP3 LMNA TMEM120B TMEM120A PTPMT1 SSC4D ZP2 STYXL1 MDH2 KIF1C ZP1 DAPK2 RHBDD2 POR YWHAG G3BP1 HSPB1 SRRM3 RAF1 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260710%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BNIP3 PHB DNM1L FIS1 MTFP1 MIB1 BAX BCL2L1 PLD1 MFN1 MFN2 SH3GL2 OPA1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis SRD5A2 SRD5A1 CYP11A1 AKR1D1 HSD3B1;HSD3B2 CYP17A1 CYP21A2 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260710%WP5193%HOMO SAPIENS Cholesterol synthesis disorders SQLE HMGCR MVD DHCR7 IDI1 MVK MSMO1 HMGCS1-1 EBP PMVK SC5D LBR FDFT1 FDPS HSD3B1;HSD3B2 DHCR24 LSS CYP51A1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260710%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRA4 PIK3CB AP2B1 PIK3CA STAT3 CREB1 GABRB3 PIK3R3 GABRB2 GABRB1 PIK3R1 ROCK1 NTRK2 AP2A1 BDNF AP2A2 NGFR GABRG3;GABRG2 SHC1-1 PIK3R2 RHOA PLCG1 CREM GABRE JAK2 GABRD GABRQ GABRA2 GABRP GABRA1 PIK3CG SLC12A5 GABRA6 PTEN GABRA5 GABRA3 GABRG1 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260710%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling AKT1 PFKFB4 LDHA MTOR RXRA HLA-DRA PDHA1 TSC2 IL10 CD86 VDR PIK3CA CD80 PRKAA2 TSC1 CYP24A1 IL12A RELA MYC HK3 GSK3B HEROIN METABOLISM%WIKIPATHWAYS_20260710%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260710%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ITGB8 ITGB7 MAPK8 ITGB6 CTNNA1 MAPK9 CDH1 LIMD1 ACTC1;ACTG2 PAK5 SGMS1 ITGB1 BUB1B-PAK6;PAK6 SRC PAK1 TEAD1 TEAD2 TEAD3 ACTA2 ITGB3 PAK3 TEAD4 ACTG1 PAK2 ACTA1 MST1 PAK4 LATS1 YWHAQ MAPK10 STK3 YAP1-1 SAV1 WWTR1 MAP4K1 ITGB5 MAP4K2 NF2 ITGB4 ACTB-1 ITGB2 CTNNB1 MAP4K5 MAP4K3 MAP4K4 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260710%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway IL11 ACE2 MAP2K6 PTPN11 TGFB1 NOX4 RAF1 MAPK1 ACTA2 SP1 IL6ST HIF1A SMAD2;SMAD3 IL11RA TGFBR1-1 MAS1 F12 PDGFD AGT AGTR1 CCN2 SMAD4 TGFBR2 RACK1 JUND RRAS COL1A1 COL1A2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C18-1 CYP2C9;CYP2C19 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260710%WP1604%HOMO SAPIENS Codeine and morphine metabolism UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 ABCC2 ABCB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2881%HOMO SAPIENS Estrogen receptor pathway CYP1A2 CYP1A1 PCK1 GPAM JUN PPARA STAT3 ESR1 PDK4 ACOX1 NR0B2 SP1 CYP1B1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260710%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCB11 SLC10A2 ABCC3 ABCC4 SLC51A SLC51B ABCC2 FABP6 ABCB1 SLC10A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260710%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX7C COX15 COX8A COX19 COX18 TACO1 NDUFA4 HIGD1A COX7A2 PET117 COX14 COX10 CMC1 TMEM177 PNKD COA3 SMIM20 COX6A1 COX20 COX5B COX5A SURF1 COX6B1 COX6C COX17 COX11 COX7B COX4I1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 PARP1 MIF EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260710%WP5443%HOMO SAPIENS Effects of MFN2 mutation TP53 DYNC1I1 DYNC1LI2 DYNC2I2 DYNC2I1 CASP8 DYNC2H1 CASP3 SNCA SYPL1 DYNC1H1 RAB7A MAP2 RAB3B RAB3A RHOT1 BAX TRAK1 MFN2 KIF1B ATAT1 RABAC1 DCTN1 TUBB3;TUBB6 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260710%WP5461%HOMO SAPIENS Primary ovarian insufficiency LMNA CLPP AR LAMC1 KHDRBS1 BNC1 ALOX12 CPEB1 ESR2 CYP19A1 SOX8 ERCC6 BLM HSD17B4 PGRMC1 HSD17B1 GALT PRDM1 SGO2 STAG3 EIF2B1 EIF2B4 ATG9A DCAF17 WT1 NUP107 WRN XRCC4 TGFBR3 LIG4 CYP17A1 POLR2C FMR1 ZP3;POMZP3 PPM1B FIGLA DAZL MSH5 DMC1 POLR3H EXO1 COX10 PRORP RCBTB1 MEIOSIN POF1B MEIOB SIL1 HFM1 SOHLH2;CCDC169-SOHLH2 NANOS3 LARS2 BMPR1B LGR4 PREPL MSH4 BMPR1A NOBOX AARS2 NUP43 SYCP2L BRCA2 SALL4 AIRE BMPR2 WDR62 GDF9 MST1R HMMR STRA8 SYCE1 CAV1 RAD51 ANTXR1-1 SOHLH1 NBN KASH5 SWI5 HELQ XRCC2 ERAL1 ATM PMM2 RFWD3-2 HARS2 DIAPH2 H1-8 HROB EIF2B2 LHX8 MCMDC2 ELAVL2 BMP15-1 FANCI C1orf146 FANCM MRPS22 FANCL TWNK FANCA FOXL2 NR5A1 SPIDR FANCC C14orf39 ZAR1 MCM8 HAX1 MCM9 PSMC3IP SLX4 SHOC1 EIF2B5 PCCA CCDC185 MGME1 PCCB MND1 CENPE FSHR XPNPEP2 ATG7 SPATA33 POLG ESR1 GNAS-1 AMHR2 BMP6 MLH1 EIF4ENIF1 TP63 NOTCH2 STAR AMH GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST3GAL1 ST3GAL2 HEXB HEXA ST3GAL4 ST8SIA6 NEU3 NEU4 ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260710%WP5174%HOMO SAPIENS Ulcerative colitis signaling IL2RG GATA3 TNF STAT6 IL10 TGFB1 IL4 IL5 TLR2 IL13 NOD2 NFKB1 MAF NFATC1 HLA-DMA FOXP3 IL4R IFNG DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades CLTC CLU C8G F2 SERPINF2 F5 F7 APOA2 F8 F9 MASP2 MASP1 CFD CPB2 SERPINC1 PLG TFPI LMAN1 C6 C7 PLAT SERPINA5 C9 CD55 F10 SERPIND1 C1QB C3-1 PLAU C1S PROC C1R F2R C5AR1 C2 C3AR1 LOC110384692;C4A;C4B_2;C4B VWF CR2 C1QC F13B F3 PLAUR CR1L;CR1 KNG1 SERPINE1 BDKRB1 CFH-3 F12 SERPING1 FGB KLKB1 CFB CFI THBD SERPINA1 PROS1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis JMJD7-PLA2G4B;PLA2G4B FADS2 PLA2G5 FADS1 ELOVL5 ELOVL2 PLA2G6 PLA2G4A ACOX3 ACOT2;ACOT1 ACSL1 ACOX1 ACSL4 ACSL3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260710%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression RXRA ITPR1 KDM1A KDM6B TPH1 CACNA1C ITPR2 KDM1B ITPR3 GRIN2A CALB1 ATP2B4 BCL2 PVALB G6PD KCNQ2 GRIN2C TPH2 GRIN2B GRIN1 GRIN2D GCLC KCNQ3 GRM5 CYP27A1 SLC8A1 GGT1 VDR ATP2B3 ATP2B2 KDM3A CYP27B1 ATP2B1 NFE2L2 CHRM1 GSR INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260710%WP1984%HOMO SAPIENS Integrated breast cancer pathway FOXO1-1 PHB RPP38 CCND1 CDH1 HIPK2 EP300 TFPI TSC1 AR CDC25A GADD45A CHEK2 CHEK1 CDC25B MAX MYT1 MAP3K13 CYP19A1 CDK7 BARD1 ATF1 XRCC3 FOSL2 AHR BLM NOXA1 PTEN RAC1 MMP1 PLK1 BRCA1 DAG1 PIAS1 RALA-1 ATR SIRT1 CERK CREB1 PAK1 MAPK1 RHEB NF1 KRAS NCOA3 RAD54L MTOR GDI1 TGFBR1-1 WEE1 JAK1 RB1 AURKA USP15 TGFBR2 MSH6 SELENOK E2F1 HDAC1 STAT1 CDK4 TP53 SMAD6 SMAD7 EGFR BAK1 FAU BID CSNK1D JUN IRS1 RASGRP3 STK11 BCL2 ARAF BAX MYC MSH2 MDM2-2 AKT1 TRADD CASP9 SMAD2;SMAD3 NUP85 CASP8 TPR BMPR1A CASP3 MRE11 TSC2 PIK3R2 FADD GSK3A BRCA2 RAP1A BMPR2 SMAD4 RAD50 RAD51 BRAF NFKB1 FOSL1 ERAL1 ATM VEGFA CDK2 SMARCA4 HMGCR BACH1 PML BAD SMAD1 CHUK ESR1 NAB1 MAP3K7CL ZMYND8-1 RHO ZMIZ1 ALKBH1 SP1 RALGAPA1 CCNB1IP1 PKIA UBE2F CDC42 PLK3 FER ZNF655 PIGR USP38 IMPA1 ABL1 TAB1 RASGEF1A ANXA1 DCAKD ITPKC GRN EDAR USP16 MYCBP2 ODC1 USP21 FILIP1 PPP4R3A JAKMIP1 PPP4R3B CTNNB1 RRAS DHTKD1 GASTRIN SIGNALING%WIKIPATHWAYS_20260710%WP4659%HOMO SAPIENS Gastrin signaling EGR1 FOXO1-1 CCND1 SERPINB2 PTPN11 CDH1 RPS6 TCF4 RAF1 PRKD2 PRKD1 CXCL8 MAP3K11 PLCG1 PTGS2-2 GSK3B RAC1 MEF2D CD44 MEF2B;BORCS8-MEF2B PIK3CA STAT3 CREB1 PIK3R3 PIK3R1 GNAQ EIF4EBP1 ANXA2 PRKCD RELA LAMTOR3 PAK1 KLF4 MAPK1 MAPK3 PRKCQ JAG1 ELAVL1 KRAS MTOR SERPINE1 TJP1 RPS6KB1 ATF2 CDKN1A ELK1 PRKCH FOS BIRC5 EGFR MAPK8 KAT5 JUN CDKN2A MAPK14 IL2 IRS1 MYC BCL2L1 AKT1 FOXO3 MMP7 CASP3 PXN PIK3R2 BIRC3 BIRC2 SLC9A3 PTK2 NFKB1 GRB2 JAK2 MEF2C CDKN1B SLC9A1 VEGFA HRAS ARRB1 ARRB2 MAPK9 HDAC7 CCKBR BAD ITGB1 SOS1 CRK ROCK1 CHUK SRC MAP2K2;MAP2K1 IKBKB PRKACA-1 SP1 CLDN1 PRKCE CDC42 BMP2 KIT FYN BCAR1 SHC1-1 PRKCA YES1 ARHGEF28 HDC CHGA RHOA RHOD GAST CTNNB1 NFKBIA RHOB PPARG COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260710%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity SUSD4 CLU C5AR2 CD59 C8G CSMD1 DEDD CX3CR1 MASP2 MASP1 CFD CAP1 C6 ATP11A C7 C8A C9 CD55 C1QB C3-1 C1S C1R C5AR1 C2 C5 C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 APAF1 C1QC PARD6B TYRO3 PARD3 GAS6 MFGE8 MARK2 MERTK VTN AXL CR1L;CR1 CFH-3 FASLG CASP10 COLEC11 FCN2;FCN1 PRKCI XIAP DIABLO-1 PRKCZ IFNG BAK1 BID FAS BAX ITGB3 ATP10A CASP9 CYCS-1 CASP7 HTRA2 CASP8 CASP3 ITGAM TGFB2 ITGB2 TGFB3 ATP8B1 CX3CL1 ITGAX ITGAV MBL2-1 ATP8B2 TGFB1 MPP5 C8B MBP SERPING1 PATJ C4BPA C4BPB ATP11C SCRIB CFB PLSCR1 LLGL2 CFI MARK3 CFP ATP8B3 DLGAP5 PARD6A PLSCR3 MARK1 PLSCR4 CRB2 COLEC12 CRB1 COLEC10 PROS1 PARD6G TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260710%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc SUCLG2 FH DLAT CS PCK1 PDHA1 MDH1 PC ACLY DLD ACO1 DLST IDH1 IDH3A SDHA OGDH GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260710%WP4830%HOMO SAPIENS GDNF RET signaling axis GDNF GATA3 SLIT2 SPRY1 PAX2 BMP4 GREM1 ALDH1A2 HSPB11 WT1 RET FOXC2 FOXC1 HOXD11 SOX11 GLI3 HOXA11 AGTR2 FAT4 SOX17 SALL1 ROBO2 LHX1 SIX2 EYA1 GFRA1 CTNNB1 HOXC11 IFT27 ROBO1 HNF1B PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260710%WP3527%HOMO SAPIENS Pre implantation embryo EGR1 NKX2-1 NANOGNB CELF3 NR3C2 FOXQ1 KHSRP DPPA3 ZFP42 CDH1 DLX2 PADI6 BARX2 LEUTX NLRP5 DPRX-1 CDX2 MOS TPRX1;RAX2 ZSCAN4 MXD1 IRF4 DNMT3L FOXD1 SOX2 SOX8 FOSB DDIT3 MTA3 SIX3 AQP3 ESRRA TFAP2E;TFAP2B SMARCA4 POU5F1;POU5F1B GATA3 ZAR1 ZFP36L2 GATA2 TCF7L1 PBX1 NANOG;NANOGP8 MACROH2A2 IRX5 KLF4 ZFP36 ATP1A1 TEAD4 AQP9 BATF3 ELAVL1 E2F5 HNRNPAB SOX11 TBX3 MYBL1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment NRP1 ITGB6 IFITM3;IFITM2;IFITM1 CD86 TGFB1 CD80 KDR CTLA4 FAS BAG3 CCL5 CCR5 CSF2 CXCR4 CXCL10 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCR3 HLA-DRA CSF1R CCL13;CCL2 CCR2 CSF1 CSF2RA FASLG CXCL12 VEGFA LAG3 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome CUL3 HDAC3 GBX2 DGCR8 HES1 DROSHA RAN HIRA GLUD1;GLUD2 HIRIP3 COMT SERPIND1 TSKS ZDHHC8 ZNF274;ZNF74 RCC1 GSC2 RAF1 TANGO2 TXNRD2 C22orf39 THAP7 TSSK2 RTL10 NPRL2 NPRL3 TRMT2A ESS2 GP1BA KLHL22 GP5 LZTR1 LRRC74B AIFM3 XPO1 CLDN5 MRPL40 UFD1 TNPO1 SCARF2 DGCR2 RBX1 SEPTIN11-1 RTN4R GP1BB RANGAP1 SLC7A4 DRD2 GNB1L PRODH;LOC102724788 DEPDC5 CCDC188 ARVCF CRKL LOC102724770;DGCR6;DGCR6L RANBP1 SEPTIN8 MAG CBX5 SLC2A4 P2RX6 EMC10 CYP26A1 PLK1 SEPTIN5 SRF SREBF1 NKX2-5 CLTCL1 RTN4 CYP26B1 CLDN3 CDC45 ALDH1A2 H4C1 PRKN RELN ASF1A POLR2A TP53 FGFR2 EGFR GP9 HAND2 FGFR1 BCL2 FGF8 SHH SREBF2 FGF10 VWF PPP1CB SHOC2 PITX2 RORC OAT NCOR1 ALDH4A1 CHRD ARNTL SNAP29 ACTC1;ACTG2 MED15 TBX1 KPNB1 ACTA2 CLDN1 CDC42 MALT1 PAK4 PI4KA CDH15 FOXC2 SLC25A1 FOXC1 FOXA2 PAX3 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP5094%HOMO SAPIENS Orexin receptor pathway PLCD1 DAGLA FOXO1-1 GRIA1 PDHB MAPK8 SLC1A2 TNF VHL PTPN11 FSHB ADIPOQ MAPK14 NOX4 RPS6 LHB IL6 NPFFR1 PLD1 PDK1 GNRH1 PRKD1 HIF1A CASP9 CASP3 BMPR1A PIK3R2 CXCL8 CGA TH IL1B GNA11 OPRK1 CXCL2;CXCL3;CXCL1-1 HCRTR2 NFE2L2 HCRTR1 SLC2A1 SLC2A4 GHRL NPVF HCRT RUNX2 RPS6KA1 ARRB1 ARRB2 PDPK1 MAPK9 IL10 PRKCB STAT3 IL4 PRKAA1 POMC CREB1 RRAGC DYNLT1 PIK3R1 GNAQ SMAD1 NPY EIF4EBP1 PRKCD GNAS-1 MAPK7 CAMKK2 MAP2K2;MAP2K1 GCG SMAD5 MAPK1 PRKCE MAPK3 GNAI1 SGK1-1 LEP MTOR IL9 EIF4B RPS6KB1 PRKCA BMP7 CCK PRKCZ STAR SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260710%WP4658%HOMO SAPIENS Small cell lung cancer TP53 FN1 COL4A6 BAK1 RXRG BID CCND1 TRAF4 LAMA4 CKS1B LAMC1 BIRC7 CDKN1C BCL2 ITGA2B CCNE1 BAX MYC COL4A2 BCL2L1 COL4A1 AKT2 LAMC3 AKT3 LAMC2 AKT1 APAF1 GADD45A CASP9 TRAF1 CYCS-1 CASP8 TRAF3 LAMA1 CASP3 LAMA3 SKP1 PIK3R2 BIRC3 MAX BIRC2 DDB2 LAMB3 CCNE2 LAMB4 PTK2 NFKB1 LAMB1 PTGS2-2 CDKN1B CKS2 CDK2 PTEN PIK3CD ITGAV ZBTB17 RARB GADD45B PIK3CB NOS2 RXRA GADD45G POLK ITGA3 ITGA2 PIK3CA ITGA6 PIK3R3 ITGB1 PIK3R1 COL4A4 CHUK COL4A3 COL4A5 RELA IKBKB LAMA5 IKBKG E2F2 E2F3 LAMB2 RB1 CDKN1A FHIT E2F1 NFKBIB TRAF2 CDKN2B NFKBIA CDK6 TRAF6 LAMA2 CDK4 TRAF5 RXRB SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260710%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways EGR1 SLC1A3 EN1 HSPD1 HES1 TNF HES5 MAZ TF SST DLX2 TPH1 EP300 AR ALDOA TLX3 CHRNB4 DDC LOC110384692;C4A;C4B_2;C4B SSTR1 HIF1A RET CXCL8 MYB G6PC1 ESR2 THRB IL13 NKX2-2 GABRA1 PLP1 VIPR1 VIPR2 PKNOX1 TSPYL1 GPD1L-1 ADCYAP1 CTCF ADCYAP1R1 DEAF1 TAC1 SPTBN1 HTR2A PHOX2A FEV CC2D1A GATA2 YWHAE CDCA7L HTR3A YWHAB ECE1 NOS1AP MAP2 HTR1A ATP1A3 YWHAG CREB1 KCNJ8 SNAP25 YWHAH MBD1 CHRNA7;CHRFAM7A IL6R YBX1 NTRK2 BDNF LMX1B SCN5A GRIN1 PPARGC1A GCK RUNX3 KCNQ1 SCN4B SCN3B CHRM2 HDAC1 KCNH2 FMO3 CREBBP JUN SSTR2 NKX3-1 IL1RN IL6 HADHB-1 CHRNA4 CPT1A GNB3 ASCL1 AVP TPH2 SLC25A4 SNTA1 VAMP2 MAOA HADHA ACADM SP3 SLC6A4 RORA CASP3 CHRNB2 CAV3 SOX2 SLC9A3 TH IL1B NFKB1 MECP2 CREM NFKB2 TP73 MEF2C VEGFA POU5F1;POU5F1B GATA3 PRKACB-1 IL10 HDAC9 RYR2 PBX1 NANOG;NANOGP8 HSP90B1 AQP4 PRKACA-1 SP1 POU2F2 FOXM1 CEBPB PPARGC1B PRKAR1B YWHAQ PRKAR1A BHLHE40 NEUROD1 TACR1 NFYA-1 NR3C1 GJA1 CHAT REST IL1A PHOX2B YWHAZ POU3F2 PRKAR2B PRKAR2A PAH TPPP CTNNB1 GAPDH-1 NGF FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260710%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ACO2 CS ALDH2 ALDH3A2 ACSS2 ALDH9A1 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome CDK12 CCL8 CCL1 GRB7 PPP1R1B CCL23;CCL15 SOCS7 ACACA CCL16 CCL11 RFFL CCL4L2;CCL4L1;CCL4 CCL13;CCL2 LIG3 PEX12 TEC MED1 AP2B1 CCL14 CCL3L1;CCL3L3;CCL3;CCL18 ERBB2 MMP28 DHRS11 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 SLFN11;SLFN13 AATF IKZF3 CISD3 DUSP14 RDM1 LASP1 CCL5 ARL5C C17orf98 C17orf50 GPR179 UNC45B DDX52 LYZL6-1 MRPL45 SRCIN1 RAD51D SLFN14 ZNF830 SLFN5 FNDC8 GGNBP2 PNMT FBXO47 CCT6B MLLT6 RPL23 FBXL20 NEUROD2 MIEN1 ZNHIT3 PIP4K2B C17orf78 PGAP3 ASIC2 GAS2L2 HEATR9 PIGW TAF15 LHX1 TMEM132E STARD3 RASL10B PCGF2 CACNB1 SYNRG EPOP MYO19 PLXDC1 NLE1 ARHGAP23 TADA2A STAC2 HNF1B SLFN12L;SLFN12-1 TCAP AGE RAGE PATHWAY%WIKIPATHWAYS_20260710%WP2324%HOMO SAPIENS AGE RAGE pathway FOXO1-1 MSR1 EGFR MMP14 MAPK8 STAT5A STAT5B JUN MAPK14 IRS1 MSN RAF1 AKT1 MMP7 HIF1A CASP9 DDOST CYCS-1 SMAD2;SMAD3 CASP8 CASP3 SOD1 LGALS3 MMP13 PLA2G4A MMP9 INSR NFKB1 JAK2 DIAPH1 RAC1 IRAK4 NOS2 TIRAP MAPK9 PRKCB STAT3 INS;INS-IGF2 ROCK1 CHUK SRC PRKCD RELA MAP2K2;MAP2K1 IKBKB MAPK1 SP1 CDC42 MAPK3 SHC1-1 MYD88 PRKCA NOS3 ATF2 RHOA INHBB ALPL NCF1 FOXO4 PRKCZ MMP2 NFKBIA EZR AGER STAT1 VISUAL CYCLE%WIKIPATHWAYS_20260710%WP5534%HOMO SAPIENS Visual cycle RDH12 ABCA4 RBP3 RDH10 RDH11 LRAT RPE65 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RBP1 RDH5 OPN1SW RHO RDH8 RLBP1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260710%WP4842%HOMO SAPIENS Mammalian disorder of sexual development FGF9 FGFR2 FOXL2 NR5A1 SRY RBFOX2 DMRT1 GATA4 CBX2 DHH PBX1 MAPK11 AMHR2 SRD5A1 RSPO1 SOX9 EMX2 WT1 PTGDS WNT4 FST SOX8 AMH CTNNB1 INSL3 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260710%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination AXIN1 FGF9 FGFR2 FOXL2 SRY SOX9 GADD45G WNT4 MAP3K1 RHOA MAPK11 ROCK1 CTNNB1 MAP3K4 MAPK1 GSK3B BDNF TRKB SIGNALING%WIKIPATHWAYS_20260710%WP3676%HOMO SAPIENS BDNF TrkB signaling HRAS TRPC6 ARC GAB1 CREB1 TSC1 SOS1 NRAS EIF4EBP1 NTRK2 HOMER1 MAP2K2;MAP2K1 BDNF MAPK1 GRIN1 RHEB AKT1 DLG4 EEF2K TRPC3 KRAS MTOR MKNK1 RPS6KB1 SHC1-1 TSC2 BRAF PLCG1 GRB2 ADCY1 PIK3CG GAB2 RPS6KA1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260710%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFS4 NDUFS2 NDUFS1 NDUFS3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB11 DMAC2 NDUFB5 ECSIT FOXRED1 NDUFB4 TMEM186 NDUFB3 TMEM70 NDUFV1 NDUFB2 TIMMDC1 NUBPL NDUFB1 ACAD9 NDUFAF6 NDUFAF4 NDUFAF2 NDUFAF3 TMEM126B NDUFAF1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFAF7 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA5 NDUFAB1 NDUFS5-1 NDUFA13 NDUFA12 NDUFA10 NDUFC1 NDUFB10 NDUFS6 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260710%WP5382%HOMO SAPIENS TGFB Smad signaling SPARC TGFBR2 TGFBR3 WWTR1 SMAD2;SMAD3 POSTN SERPINE1 TGFBR1-1 CCN2 SMAD4 YWHAG FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP357%HOMO SAPIENS Fatty acid biosynthesis ACACA SCD HADH ACSL6 ACSL5 ACSS2 ACACB PECR PC FASN DECR1 ACLY MECR ACSL1 ECH1 ECHDC1 ECHS1 ACAA2 ACSL4 ECHDC2 ACSL3 ECHDC3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260710%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCD1 PLCE1 FFAR1 PKD1 PLCZ1 PLCB3 PLCG1 ITPR3 GNA11 PLCH1 PLCB1 PLCB2 PLCG2 PLCL1 PLCD3 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260710%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging AKT1 FOXO1-1 MTOR IGF1R SIRT1 PTEN ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260710%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling RAC1 HRAS PTPN11 MAPK14 GAB1 ITGA6 PIK3R1 SOS1 IRS1 LAMC1 EIF4EBP1 SRC PRKCD LAMA5 MAPK1 LAMC2 MAPK3 AKT1 LAMB2 MTOR LAMA1 LAMA3 SHC1-1 PIK3R2 PRKCA LAMB3 RHOA PTK2 LAMB1 GRB2 ITGB4 IRS2 LAMA2 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260710%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 DDX58 IFIH1 IRF3 TLR7 TLR8 TNFRSF11A MR1 TLR3 MAVS INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260710%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRF7 TANK MAP3K3 MAPK8 MKNK2 IRAK4 EIF4E MAP2K7 MAPK9 RPS6KA5 MAP2K6 MAP3K1 MAPK14 IRAK1 MAP3K14 MAPK11 MAPKAPK2 CHUK RELA MAP2K2;MAP2K1 MYC IKBKB MAP3K7 MAPK1 MAPK3 SAFB IL1RAP MAPK10 MKNK1 TAB1 IL1R1 MYD88 MAP3K8 ATF2 MBP IL1A ELK1 NFKB1 MAP2K3 MAP2K4 NFKBIB IRAK2 FOS NFKBIA TOLLIP TAB3 TAB2 TRAF6 MALE INFERTILITY%WIKIPATHWAYS_20260710%WP4673%HOMO SAPIENS Male infertility CLU AHRR TNF EP300 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LTF AR NQO1 SHMT1 XPC RFC1 SOD3 ESR2 SRD5A2 PSAT1 XRCC3 ERCC1 UBD NFE2L2 PEX10 ETV5 AHR ERCC2 PON2 PON1 KLK3;KLK2 CYP1A1 NOS1 PARP1 CYP26B1 GNAO1 CCNA1 SIRPA;SIRPB1;SIRPG REC8 APOB ABCB1 USP8 HLA-DRA H4C1 FASLG XRCC4 XRCC5 LIG4 TMEM132E THBS1 CYP17A1 MMP2 DAZL MSH5 CREBBP PEMT BCL2 FAS MDM2-2 CCNK AGO2 SLC46A1 IHO1 CCNT1 UBR2-2 RAG1 NANOS1 PRDM7;PRDM9 PRM3 MSH4 SPATA17 TSSK6 TSSK4 BRCA2 DDX4 CHD2 DND1 MOV10L1 PUM2 STRA8 CCNT2-1 PIWIL2 KDM3A CRISP2 MMP9 INSR EPPIN;EPPIN-WFDC6 PIWIL1 PIWIL4 PIWIL3 UBE2B XRCC2 SPO11 ATM SEPTIN12 YBX2 HORMAD2 HORMAD1 MSMB PRMT6 PACRG TEX15 USP26;USP29 CXXC1 CLOCK ABLIM1 OR2W3 LRWD1 CAT NOS2 CDC42BPA MLH3 CTCFL TRIP13 BRDT RGS9 POLB ARNTL CDK9 POLG PMS2 ESR1 GPX1 MLH1 DDX20 MTRR SOX5 MTR-1 NOS3 MTHFR BHMT FOLH1B;FOLH1 MTHFD1 TCN2 SLC16A7 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260710%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP1 MMP14 NOS2 SCN8A MMP21 MMP20 MMP24 PRKCB MMP27 TKTL1 MMP28 MMP11 MMP16 SNAP25 MMP15 MMP17 MMP19 MMP8 MMP25 C3-1 PRKCD BDNF TRPA1 PRKCE TRPV1 PRKCQ MMP7 PRKD3 MMP23B MMP12 MMP3 PRKCA MMP13 MMP9 SORD PRKCG PRKCI PRKCH SCN10A SCN9A PRKCZ SLC2A1 MMP2 AGER MMP10 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP3869%HOMO SAPIENS Cannabinoid receptor signaling DAGLA CYP1A1 MAPK8 PRKACB-1 MAPK9 MAPK14 MAPK12 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAPK13 MAPK11 NAPEPLD DAGLB PRKACA-1 FAAH MAPK1 MAPK3 CYP2C9;CYP2C19 PRKAR1B MAPK10 PRKAR1A CNR2 CNR1 ADORA2A PRKAR2B AHR ADCY1 ADCY7 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260710%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis CPLX1 GDI1 SYT1 STXBP1 SNAP25 CACNA1B RIMS1 CACNA1A RAB3A UNC13A NSF STXBP5 STXBP6 SYP RPH3A VAMP2 NAPA METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260710%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway AHCY MAT2A MAT2B TXN MSRA MTR-1 MSRB2 MSRB3 ODC1 SRM IL4I1 MAT1A BHMT TAT CHDH AMD1 APIP MRI1 MTAP ADI1 SMS ENOPH1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260710%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GPI GCK GFPT1 PGM1 UGDH HK2 HK3 HK1 PGM3 GALE UXS1 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SLC1A2 SLC1A3 HES1 HES5 DPPA3 ZFP42 CDH1 CACNG2 TPH1 FABP7 DLL1 AP2A1 AP2A2 DLG2 HOMER2 GAD2 SHANK1 CNP HTR5A MOG GAD1 CDH2 FEV KCNJ6 TNC CASK SHANK3 MAP2 HTR1A SNAP25 HOMER3 ADRA2C ADRA2B ADRA2A TBXT HOMER1 LMX1B GRIN2B KLF4 GRIN1 DLG4 CD34 NR4A2 NEFL GABBR1 NEFM ROBO1 ERAS DLG1 SLC18A3 OLIG2 SOX10 SYP ACHE FGF4 NGFR SLC6A5 SLC6A9 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC17A6 SLC17A7 MSX1 SOX2 SOX17 TH NODAL PECAM1 GABBR2 ESRRB SNAI1 SNAI2 GATA6 POU5F1;POU5F1B NLGN1 NOTCH1 LEF1 GATA4 ITGA6 ITGB1 NANOG;NANOGP8 TPM1 AQP4 BMP4 HNF4A RIMS2 ALDH1L1 PPFIA1 BSN RBFOX3 CSPG4 FBXO15 PAX6 SOX9 TBR1 TWIST2 MSX2 LIN7A FUT4 EVX1 CHAT DLG3 CD24 MBP NES PCLO ERC1 GFAP DPPA2 DCX GLRA1 CLDN11 GLRA2 LHX1 GLRA3 UNC13A HES3 GLRB KRT15 RIMBP2 FOXD3 MIXL1 GLS GLUL GPHN FOXA2 PAX3 TUBB3;TUBB6 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases ALDH6A1 TK2 AGXT2 RRM2-1 RRM1 CAD TYMS RRM2B DPYS TYMP CPS1 ABAT NT5C UPB1 NT5C3A DPYD GLS2 DHODH UMPS OTC MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260710%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ACADSB HSD17B10 DECR1 ECI1 EHHADH-1 ECHS1 ACAA2 ACSL3 ACADL ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment MUC1 IL6 NFKB1 CHUK TNF RELA IKBKB NFKBIA IKBKG BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260710%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment CFL1 PTPN11 STMN1 RAF1 APAF1 FRS2 ARHGAP35 RTN4R PARD6B PLCG1 CFL2 LIMK1 GSK3B DIAPH1 PIK3CD RAC1 MAP3K3 RPS6KB2 PIK3CB YWHAE PIK3CA STAT3 YWHAB TIAM2 PARD3 YWHAG GAB1 CREB1 YWHAH MAPKAPK2 NRAS EIF4EBP1 NTRK2 PRKCD BDNF PAK1 IQGAP3 MAPK1 SH2B2 KIDINS220 MAPK3 KRAS MTOR MKNK1 RPS6KB1 PRKCG MAP3K5 PRKCI PRKCH MAP2K4 SORT1 PRKCZ DOCK7 TRAF6 TP53 SMPD1 MAPK8 BCL2L11 TIAM1 EIF4E MAP2K7 JUN MAPK11 IRS1 BCL2 BAX MYC ARHGDIA NGFR LINGO1 TCF7 EEF2 AKT1 FOXO3 EEF2K TRADD CASP9 CYCS-1 CASP8 FADD RAP1B MAP2K5 GRB2 TP73 PIK3CG HRAS PDPK1 LEF1 PRKCB TCF7L2 TCF7L1 RAPGEF1 MAP3K1 BAD SOS1 CRK ROCK1 CHUK ROCK2 MAPK7 MAP2K2;MAP2K1 IKBKB WASL PRKCE IKBKG CDC42 YWHAQ SHC1-1 PRKCA YWHAZ RHOA BMP7 PARD6A NPTX2 IRS2 RND3 CTNNB1 NFKBIA SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation MIGA1 CLTC DRC3-1 TOM1L2 GPR85 LLGL1 GAS8 IQCA1 DRC7 TNF CLEC16A PLD6 RAB39B HBP1 GDI2 WDR41 EFCAB2 ARG2 RMI2 RMI1 PPP1R12A TOP3A ITPK1 IQCD TCTE1 IQCG SMCR8 GPS1 MIEF2 RASD1 CCDC65 ULK1 FNIP1 IRF8 FNIP2 FBXL13 MYO16 SHMT1 MYO15A DRG2 LDHA PCK1 CARM1 G6PC1 PARD6B FOXA1 ETV5 CFL2 LIMK1 BLM RPTOR PTEN CLTB PRKAG2 TRAF3IP1 IFT172 SREBF1 PRKAB1 MED9 STAT3 FHOD1 IFT80 CLTA PRKAA1 ARMC8 PARD3 CREB1 PRDM1 IFT88 CRY2 IFT81 RELA COPS7A ATPAF2-2 USP8 MTOR RAB10 CDK1 TFEB MYD88 HSPB11 MLST8 TFE3 PRKN RAB8A PRKCI HES6 TP53 WDR26 BCL2L11 JUN RANBP9 MKLN1 GID4 PEMT BAX MYC MAEA NR1H2 NR1H3 TTC30A;TTC30B BIRC2 RB1CC1 IL1B NFKB1 RNF41 RAI1 COPS4 IFT20 BCL6 COPS3 TNFRSF13B COPS6 NT5M IFT22 COPS5 TOLLIP ATG13 COPS2 IFT27 CRY1 CLOCK COPS8 TTC26 IFT52 APBB1 IFT57 ARNTL RRAGA ATG101 MAP3K14 ROCK1 IFT46 PPP1R14A PER1 IFT74 RMND5A FLII C9orf72 DRC1 CLUAP1 YAP1-1 FLCN RHOA WWTR1 GRIP1 FOXA2 APP FERD3L ALKBH5 MPRIP DENR TLR4 MIGA2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP4149%HOMO SAPIENS White fat cell differentiation CEBPA TLE3 FOXO1-1 RARA NR2F2 GATA3 CTNNA1 STAT5A SREBF1 STAT5B GATA2 CEBPD TCF7L1 MECOM CREB1 INS;INS-IGF2 IRF4 KLF4 NR1H3 EGR2 CEBPB EBF1 KLF15 RORA NR3C1 WNT10B KLF2 KLF5 IRF3 ZNF423 DDIT3 PPARG OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL1 SCD5 ELOVL6 SCD FADS2 FADS1 ELOVL5 ELOVL2 FASN ACOT2;ACOT1 ACSL1 ELOVL3 ACSL4 ACSL3 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260710%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer KRAS SOS2 SHC1-1 JUN GAREM2 ELK1 BRAF SOS1 ALK MAP2K2;MAP2K1 MYC RAF1 FOS MAPK3 KSR1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260710%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence TP53 ELAVL1 SIRT3 MDH1 PARP1 GOT2-1 MDH2 PRKAA1 SIRT1 GOT1-1 IL1B NAMPT IL6 NMNAT2 CCL27 RELA G6PD SLC2A1 SLC2A4 SIRT5 SIRT2 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260710%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway ACE2 IL7 TMPRSS2 TNF IL10 CCL13;CCL2 CCL3L1;CCL3L3;CCL3;CCL18 CXCL8 AGT IL2RA IL2 IL1B IL6 CSF3 CXCL10 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260710%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation EDN1 AKR1B1 ANXA5 MITF S100A6 PTGER4 PTGER1 ANXA2 PTGER2 PTGER3 PTGIR EDNRA EDNRB PTGDR PPARGC1B ANXA6 PPARGC1A PTGFR HPGD ANXA8;ANXA8L1 HPGDS TBXA2R SOX9 PTGFRN ANXA1 PTGS1 S100A10 ANXA3 ANXA4 SCGB1A1 PTGDS PTGIS PLA2G4A HSD11B1 TBXAS1 HSD11B2 CYP11A1 PTGS2-2 PTGES ABCC4 CBR1-1 PRL PPARG STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260710%WP430%HOMO SAPIENS Statin inhibition of cholesterol production PDIA2 CETP HMGCR MTTP APOA2 LDLR APOA1 LPL DGAT1 LCAT APOA4 APOA5 LIPC APOC1 APOC2 LRP1 ACSS1 PLTP FDFT1 APOC3 APOE APOB SQLE SOAT1 ABCA1 CYP7A1 SCARB1 ABCG8 ABCG5 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260710%WP2374%HOMO SAPIENS Oncostatin M signaling EGR1 SOCS3 MAPK8 PTK2B STAT5B PTPN11 MAPK14 RPS6 IRS1 RICTOR PIAS3 OSMR RAF1 AKT1 HIF1A CASP7 CASP3 PXN NFKB1 GRB2 JAK2 JUND CDKN1B VEGFA CDK2 HRAS MAPK9 PRKCB STAT3 CREB1 SOS1 PIK3R1 SRC PRKCD RELA MAP2K2;MAP2K1 IL6ST MAPK1 PRKCE MAPK3 CEBPB KRAS MTOR LIFR SHC1-1 JAK1 PRKCA JUNB PRKCH OSM JAK3 FOS NFKBIA STAT1 TYK2 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260710%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A2 SLC39A1 SLC39A3 SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A14 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC30A10 SLC30A7 SLC30A6 SLC30A8 SLC39A4 SLC30A3 SLC30A2 SLC30A5 SLC30A4 SLC30A1 SLC30A9-1 MT2A MT3 MTF1 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response TP53 BID CCND1 PIDD1 RAD17 CDC25A CCND3 CCND2 FAS CCNE1 BAX MYC MDM2-2 APAF1 FANCD2 GADD45A CDK5 CASP9 CYCS-1 HUS1B CHEK2 RFC1 CASP8 TLK1 CASP3 CHEK1 RPA2 MRE11 PMAIP1 CDC25C RAD52 DDB2 RAD50 RAD51 SESN1 CCNE2 NBN PRKDC ATM CCNB3 CDKN1B BBC3 CDK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SFN RAD9A GADD45B BRCA1 GADD45G PML ATR SMC1A RRM2B CCNB2 CCNB1 CREB1 RAD1 ATRIP ABL1 CDK1 TLK2 RB1 CDKN1A CCNG1 E2F1 CDK6 CDK4 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation BMP2 FOXO1-1 BCL2L11 SST LEFTY2;LEFTY1 SFRP1 WNT4 SMAD1 SMAD9 SMAD5 DCN CTNNB1 DKK1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260710%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence TP53 HRAS SIRT1 MAPK11 GNAQ PTGER4 NRAS PTGER1 PTGER2 GNAS-1 PTGER3 IGFBP5 GNAI1 ALOX5 ALOX15 KRAS ALOX12 LTC4S PTGS1 LTA4H RB1 PTGDS CDKN1A PTGIS ALOX5AP CYSLTR1 PLA2G4A ALOX15B TBXAS1 PTGS2-2 PTGES ADCY3 PRXL2B MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response TP53 ABL1 CCND1 RAD52 CDKN1A CREB1 CDC25A CCND3 CCNE1 ATM MYC E2F1 CDKN1B CDK6 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260710%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells NOS1 CALCA BAK1 TGFB1 PIK3CA G3BP1 PTH FFAR3;GPR42 BAX RAF1 MCU MAPK1 ACTA2 PPP3R1 AKT1 APAF1 CASP9 MTOR SMAD2;SMAD3 CASP8 TGFBR1-1 CASP3 SMAD4 BRAF PDE1B TNFSF11 MAP3K5 CRYZL2P-SEC16B;SEC16B TRPV5 RGN TNFRSF1A QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260710%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MMP1 NOS1 KEAP1 MAFG ACOX2 JUN MAFK NFKB1 PTGS2-2 NFE2L2 IKBKB CYP2A13;CYP2A6;CYP2A7-1 FOS VEGFA NFKBIA SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260710%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 SULT4A1 SULT2A1-4 SULT6B1 G6PD PAPSS2 PAPSS1 SULT1C3 SULT1C2 SULT1B1-1 GSR SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260710%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment IL2RG SOCS1 IRAK4 STAT6 TLR7 CD86 TLR8 TGFB1 CD80 STAT3 IL2RA IL4 IL2RB CTLA4 PIAS3 CCL5 CD274 CXCL10 PDCD1 CCL13;CCL2 TGFBR2 NFKB1 NFKB2 TGFB2 TGFB3 IL4R TRAF6 TLR4 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260710%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 ACOX1 ACAA1-1 HSD17B4 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260710%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy TST SUOX ETHE1 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260710%WP5606%HOMO SAPIENS Beta globin gene expression regulation DNMT1 PPARGC1A KLF1 CHD3 HBG2;HBG1 MTA2 LDB1 HBD;HBB KDM1A TAL1 LMO2 GATA1 MYB GATAD2B HDAC2 BCL11A NR2C1 ZBTB7A HDAC1 ZFPM1 NR2C2 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260710%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX JMJD7-PLA2G4B;PLA2G4B AKR1B1 ACAA1-1 PLA2G5 PLA2G6 ACOX3 ACOX1 EHHADH-1 PTGIR PPARD PTGDR PTGFR HPGD TBXA2R PTGS1 ACOX2 PTGDS PTGIS PLA2G4A PTGR1-1 TBXAS1 PTGS2-2 PTGES PTGDR2 PRXL2B CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 PPARG LIDOCAINE METABOLISM%WIKIPATHWAYS_20260710%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260710%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFRD1 IL18 HBEGF ATF3 ADAM10 EIF4E IL1R1 IL1A ZEB1 CCN1 EIF4EBP1 JUND MSTN MYOG DUSP14 NR4A3 VEGFA ANKRD1 IFNG WDR1 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260710%WP5028%HOMO SAPIENS Glycine metabolism including IMDs LIPT2 LIPT1 GLRX5 GCSH-3 IBA57 HSCB LIAS NFU1 BOLA3 ISCU AMT GLDC DLD PNPO SHMT1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260710%WP51%HOMO SAPIENS Regulation of actin cytoskeleton CHRM3 FN1 CFL1 PPP1R12A MOS F2R MSN FGF1 RAF1 NCKAP1 ARHGAP35 PDGFB GSN APC2 PFN1 FGF19 CFL2 FGFR4 LIMK1 FGF2 DIAPH1 PIK3CD RAC1 PIK3CB GIT1 MYH10 RASSF7 PIK3CA SSH2 ARHGEF6 SSH3 SSH1 VIL1 PAK5 PIK3R3 DIAPH3 PIP5KL1 PIK3R1 ENAH ARHGEF7 FGD1 NRAS WASF2 ABI2 PAK1 MAPK1 VAV1 MAPK3 KRAS FGF7 FGF23 RDX PDGFRA CHRM2 CHRM1 EGF FGF3 FGF5 FGF6 FGF9 FGFR2 F2 EGFR FGF16 IQGAP1 PIP5K1B PIP5K1A FGF20 FGF22 FGF17 FGFR1 FGF14 BUB1B-PAK6;PAK6 FGF18 CYFIP2 PDGFA FGF13 FGF4 FGF8 FGF12 FGF11 FGF10 PIK3R4 RRAS2 PIK3R5 MRAS GNA13 VCL GNA12 ARHGEF1 PXN PIK3R2 BRAF ARHGEF4 PTK2 SLC9A1 PIK3C2G PIK3C2A PIK3CG MYLK PIK3C2B RAC3 PIK3C3 SOS2 PDGFRB ITGA1 SOS1 CRK APC DOCK1 ROCK1 ROCK2 WAS MAP2K2;MAP2K1 CSK MAPK6 PAK3 ACTG1 PAK2 WASF1-1 CDC42 MAPK4 PAK4 MYL1 FGF21 MYL3 BDKRB2 BCAR1 CD14 BDKRB1 CHRM4 ARPC5 CHRM5 PIP4K2A PIP4K2B PIP4K2C RHOA ACTN1 ACTB-1 FGFR3 RRAS PIP5K1C BAIAP2 EZR SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260710%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACE2 PHB TNF ECSIT TERF2IP ACAD9 IL6 NDUFAF2 NLRP3 SIRT6 BCS1L NDUFAF1 TOMM70 MAVS NOX1 IL18 TRAF3 ACE AGT TERF2 REN NLRX1 NFKB1 TRAF6 RPS6KA1 STING1 MELANOMA%WIKIPATHWAYS_20260710%WP4685%HOMO SAPIENS Melanoma TP53 BAK1 CCND1 PTPN11 CDH1 KDR CDKN2A ARAF BAX RAF1 GRM3 AKT2 AKT3 MDM2-2 AKT1 PDE5A GADD45A VCL PIK3R2 SHC2 DDB2 BRAF ERBB4 GRB2 CALM1 EXOC7 PTEN PIK3CD RAC1 GADD45B PIK3CB HRAS SOS2 GADD45G POLK PIK3CA MITF PIK3R3 BAD RHOC SOS1 PIK3R1 GRIN2A CALM3;CALM1 NRAS STK19 PREX2 CALM2 MAP2K2;MAP2K1 PAK1 MAPK1 MAPK3 E2F2 E2F3 NF1 KRAS KIT RB1 CDKN1A RHOA CTTN E2F1 CALML6 CDK6 CALML3 RHOB CDK4 CALML4 PROLACTIN SIGNALING%WIKIPATHWAYS_20260710%WP2037%HOMO SAPIENS Prolactin signaling CBL SOCS3 MAPK8 SOCS1 FLNA STAT5A STAT5B PTPN11 JUN MAPK14 RPS6 IRS1 PIAS3 MYC RAF1 AGAP2 CTSD AKT1 CASP3 RPS6KA2 PXN PIK3R2 PTK2 NFKB1 GRB2 JAK2 PRL TEC PIK3CG GSK3B RAC1 PTPN1 PIK3CB HRAS CISH MAPK9 ERBB2 VAV2 PIK3CA STAT3 YWHAG ITGB1 SOS1 PIK3R1 SIRPA;SIRPB1;SIRPG EIF4EBP1 SRC RELA NEK3 MAP2K2;MAP2K1 PPIA PAK1 MAPK1 VAV1 MAPK3 PTPN6 MTOR FYN RPS6KB1 SHC1-1 PRLR JAK1 PPIB ELK1 YWHAZ ZAP70 NFKBIB IRS2 FOS NFKBIA GAB2 STAT1 SOCS2 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260710%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer TP53 RBBP4 PCNA CCND1 RBP1 SUV39H1 MAPK13 CDC25A CCND3 STMN1 CCNE1 MYC RAF1 MDM2-2 CCDC6 SMC3 POLE RFC5 RFC3 RFC4 RRM2-1 CHEK1 RPA2 SKP2 RPA1 DCK CDC25B POLD3 CCNE2 PRKDC BARD1 RBBP7 POLE2 RPA3 CDKN1B SIN3A ORC1 CDK2 SMARCA2 FAF1 CDC7 RRM1 FANCG HMGB1-1 MCM7 SMC1A CCNB2 CCNB1 PRMT2 TFDP1 TFDP2 MCM3 MCM4 SMC2 KIF4B;KIF4A MCM6 SAP30 TTK NPAT HLTF CDC45 RABIF DNMT1 E2F2 E2F3 ZNF655 ABL1 CDK1 HMGB2 PLK4 WEE1 PRIM1 TOP2A TYMS CDT1 RB1 POLA1 CDKN1A H2AZ2;H2AZ1 DHFR2;DHFR ANLN CCNA2-1 MSH6 E2F1 HDAC1 CDK6 CDK4 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260710%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260710%WP5088%HOMO SAPIENS Prostaglandin signaling IRF7 IL17A TNF CCL3L1;CCL3L3;CCL3;CCL18 TGFB1 IL12A IL6 PTGER4 NLRP3 PTGER2 CXCL10 KLRD1 CCL13;CCL2 CXCL9 AREG CXCL8 CCR2 CSF1 IL1A CASP1 MMP9 IL1B NFKB1 CD28 CXCL2;CXCL3;CXCL1-1 PTGES AHR PYCARD VEGFA IL17F PIK3CG IFNG OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260710%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases WNT8A FZD1 JAG2 FZD7 DLL1 FZD8 DLL3 FGF1 PRKD1 NOTCH3 NOTCH4 GLI3 HEY1 GLI2 DLL4 PRKDC FGFR4 FGF2 SMO PIK3CD PIK3CB PIK3CA PIK3R3 PIK3R1 PRKCD MAPK1 LRP6 MAPK3 PRKCQ JAG1 HES2 FGF7 PRKCG PRKCI PRKCH PRKCZ FGF3 STAT1 FGF5 HES6 FGF6 FGF9 FGFR2 FZD6 FZD9 MAPK8 WNT9B FZD10 WNT9A MAPK14 WNT8B MAPK12 FGFR1 MAPK13 MAPK11 PIK3R6 FGF18 MYOD1 FGF4 FGF8 WNT5B WNT5A FGF10 PIK3R4 PIK3R5 WNT6 BMPR1B BMPR1A PIK3R2 WNT1 WNT2 WNT3 BMPR2 WNT4 WNT10B WNT10A SMAD4 WNT3A WNT2B PIK3C2G PIK3C2A RUNX2 PIK3CG PIK3C2B WNT16 NOTCH1 PIK3C3 LRP5 MAPK9 FZD5 WNT11 FZD4 PRKCB FZD2 IHH WNT7B WNT7A SMAD1 SMAD9 MAPK7 SMAD5 MAPK6 BMP4 PRKCE MAPK4 BMP2 MAPK10 SOX9 PTCH1 PRKCA NOTCH2 FZD3 HES3 FGFR3 HEY2 RBPJ CTNNB1 PPARG GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260710%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR CILK1 RAB23 WDR19 SCLT1 TULP3 MIB1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CEP97 WDR35 IFT80 IFT88 IFT81 BBS2 BBS1 CEP19 TXNDC15 CDK20 TRAPPC11 KIFAP3 MKS1 TEDC1 TEDC2 FBF1 HSPB11 KIF3B CEP76 BBS9 CPLANE2 SASS6 CIBAR1 TTC23 BBS7 CBY1 BBS5 RABL2A;RABL2B EFCAB7 CEP295 CEP192 KATNB1 TUBD1 TUBE1 CEP162 IFT140 CEP44 DYNLT2B BBS4 TTC8 LZTFL1 TTC30A;TTC30B KIAA0753 IFT122 FUZ OFD1-1 IFT20 CEP20 IFT27 CEP120 TTC26 TCTN3 TCTN2 TCTN1 CC2D2A ARMC9 IFT52 IFT57 TMEM216 CEP104 ARL3 KIF3A DYNLT1 ARL13B EVC2 TMEM67 INPP5E IFT43 PIBF1 EVC IFT46 CPLANE1 TMEM231 TMEM17 WDPCP IFT74 B9D1 ARL6 TTBK2 DYNC2H1 CEP83 DYNC2LI1 CLUAP1 C2CD3 TMEM107 RPGRIP1L CEP43 TTC21B MKKS BBS10 BBS12 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260710%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC7A5 SLCO1A2 SLC7A8 SLCO3A1 SLCO4A1 SLCO1C1 SLC16A2 SLC16A10 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260710%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis AKT1 APAF1 CASP9 BCL2L11 CASP7 TNF CASP8 CASP3 BID FADD MCL1 FASLG MAPK14 MAPK12 BAD MAPK13 MAPK11 BCL2 BAX BCL2L1 BBC3 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260710%WP5548%HOMO SAPIENS Blood based neuroinflammation markers TREM1 TREM2 TNF TAC1 CCL11 GRN NEFL CCL13;CCL2 ADM GFAP IL1B CHI3L1 IL6 TSPO CCL23;CCL15 BDNF OLR1 CCL5 CX3CL1 CRP EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260710%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260710%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development HNF1A NOTCH1 SP7 NOTCH2 NOTCH3 NOTCH4 DMP1 ALPL BMP7 SOST KLF4 DSPP CTNNB1 DKK1 RUNX2 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260710%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260710%WP528%HOMO SAPIENS Acetylcholine synthesis PEMT CHKA PDHA1 ACHE CHAT PCYT1A MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260710%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia TP53 BCL2 ZAP70 MCL1 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260710%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome RNF8 NIPBL ATM MDC1 CBX3-1 ATR RNF168-1 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260710%WP554%HOMO SAPIENS ACE inhibitor pathway ACE2 KNG1 NR3C2 BDKRB2 MAS1 BDKRB1 ACE TGFB1 NOS3 ATP6AP2 AGT AGTR1 CMA1 REN CTSG AGTR2 CYP11B1;CYP11B2 POLYOL PATHWAY%WIKIPATHWAYS_20260710%WP690%HOMO SAPIENS Polyol pathway ALDOB SORD KHK AKR1B1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma TP53 CUL3 EGFR FKBP1A AJUBA KEAP1 EIF4E TERT SESN2 CCND1 CDKN2A RPS6 LTBR TSC1 FGFR1 MAPKAP1 STK11 RICTOR IGF1R AKT2 AKT3 REL AKT1 PIK3R5 CASP8 TRAF3 TSC2 PIK3R2 FADD BIRC2 SMAD4 SESN1 NFKB1 NFKB2 NFE2L2 VEGFA PIK3CG RPTOR PTEN RPS6KB2 PIK3CB HRAS NOTCH1 PDPK1 ERBB2 PIK3CA PRKAA1 PRKAA2 PIK3R1 NRAS EIF4EBP1 RELA IRF6 RHEB KRAS MTOR TP63 MAML1 FAT1 RB1 NOTCH2 CDKN1A MLST8 TGFBR2 DDIT4 NUMB E2F1 FGFR3 CTNNB1 CSMD3 CDK6 CDK4 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway CYP1A2 EGFR CYP1A1 GSTA3;GSTA5;GSTA1;GSTA2 MYOF HES1 AHRR TNF POLK SERPINB2 JUN TGFB1 EP300 AIP ARNT IL12A IL2 ALDH3A1 CES3 SRC NCOA1 BAX PTGES3-1 NQO1 CYP1B1 UGT1A1;UGT1A6 CDC37 SLC7A5 MGST1 IL12B IL1B JUNB JUND NFE2L2 HSP90AA1 CDKN1B AHR CAP2 IGFBP1 IFNG IL17B INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260710%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL2RG GATA3 TNF STAT6 IL21R IL10 IL21 JUN TGFB1 IL22 STAT3 IL4 IL5 TLR2 IL12A IL2 IL23R NOD2 IFNGR1 IL6 MAF HLA-DMA NFATC1 FOXP3 IL18 SMAD2;SMAD3 RORA IL12RB1 TBX21 IL12RB2 IL1A IL13 NFKB1 RORC STAT4 IL23A IL17F IL4R TLR5 STAT1 IFNG IL18RAP TLR4 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260710%WP4725%HOMO SAPIENS Sphingolipid metabolism overview SMPD1 SGMS2 UGCG KDSR CERS4 SGPP1 CERS3 DEGS1 CERS2 CERS6 CERK DEGS2 SGMS1 PLPP3 UGT8 PLPP2 CERS1 GBA2 SGPL1 SGPP2 PLPP1 SPTLC1 GBA ASAH1 SPHK2 SPHK1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260710%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CRTC2 HDAC4 GNAS-1 HDAC5 PRKACA-1 HDAC7 DNAJB1 SIK3 SIK2 CREB1 SIK1;SIK1B MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260710%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CLDN4 NRG3 AKT1 TNF TERT CCND1 TGFB1 SFRP1 CDH1 ITGA6 ALPL ITGB1 ZEB2 ERBB4 MYC MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260710%WP4921%HOMO SAPIENS Mitochondrial complex III assembly TTC19 UQCRFS1 LYRM7 UQCRC1 UQCRC2 UQCRB UQCR11 UQCR10 CYC1 UQCC1 BCS1L UQCRQ UQCC3 UQCC2 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260710%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 RBBP4 GLI4 SMARCA4 DPF2 ARID1A ARID1B SMARCD1 SMARCD2 SMARCD3 H3-3A SUZ12 CDKN2A EED EZH2 PTCH1 RB1 GLI1 DPF1 DPF3 GLI3 GLI2 SMARCE1 SMARCB1 ACTL6A SMARCC1 SMARCC2 CDK6 ACTL6B CDK4 SMO GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260710%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation RASSF1 FOXO1-1 SMAD7 CRTC2 DLK1 PDX1 PGF INS;INS-IGF2 MYC IGF1 PDGFA IGF1R MAPK1 AKT2 FOXM1 AKT3 MAPK3 AKT1 KRAS TGFBR1-1 FLT1 BRAF INSR CDK4 CDK2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260710%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPA KLF15 GATA3 SREBF1 GATA2 CEBPD CEBPG KLF2 KLF5 DDIT3 EGR2 CEBPB PPARG ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260710%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects TNF SLC25A5 ULK1 RAF1 IRS4 FRAT2 APC2 PTGS2-2 CALM1 GSK3B PIK3CD NOS1 PIK3CB ITPR1 PSMD8 PIK3CA PSMD7 RTN4 ADAM17 PIK3R3 CACNA1C PIK3R1 GNAQ GRIN2A NRAS CHRNA7;CHRFAM7A RELA GRIN2C VDAC1 GRIN2B GRIN1 MAPK1 GRIN2D MAPK3 KRAS MTOR PSMC5 MAP3K5 TRAF2 TNFRSF1A FZD6 FZD9 MAPK8 SLC25A6 MAP2K7 FZD10 BID TPTEP2-CSNK1E;CSNK1E PSMC6 IRS1 IL6 PSMC4 FAS WNT5B WNT5A PIK3R4 WNT6 PSMD12 DVL1 PSMD13 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A WNT3A INSR IL1B NFKB1 WNT2B WIPI1 AXIN1 WNT16 PIK3C3 VDAC2-1 MAPK9 WNT11 VDAC3 PLCB3 BAD PLCB4 WNT7B WNT7A ITPR2 ULK2 ITPR3 TUBAL3 APC PLCB1 CHUK PLCB2 IKBKB PPP3CC TUBA1C TUBA1A ATP2A3 TUBB1 ATP2A2 TUBA3E;TUBA3C-1 TUBB2B;TUBB2A IL1A FZD3 TUBB4B TUBA4A TUBB4A;TUBB;TUBB8B;TUBB8 CTNNB1 IRS2 AGER AXIN2 TUBB3;TUBB6 CACNA1D CACNA1F TUBA8 KIF5B GPR83 CACNA1S ATF4 FZD1 LRP1 CSNK1A1 FZD7 FZD8 CYBB SFRP4 PPP3R1 NOX1 APAF1 CDK5 PSMD2 ADAM10 MME CALM3;CALM1 CSNK2B CALM2 APOE LRP6 CSNK2A2 SNCA WIPI2 ATG14 CSNK2A1;CSNK2A3 APH1A APH1B ATG2A BECN2 CALML6 CALML3 CALML4 LPL NOX4 ARAF SLC25A4 AKT2 AKT3 CAPN2 AKT1 CAPN1 CASP9 CYCS-1 CASP7 CASP8 CASP3 PIK3R2 FADD CSF1 BRAF RB1CC1 PSMD9 DKK4 PSMD6 PSMD4 PSMD3 XBP1 PSMD1 PSMC2-1 DKK2 EIF2AK3 NRBF2 EIF2S1 DKK1 ATG2B ERN1 ATG13 DDIT3 IDE PSMA5 PSMA6 PSMA3 ATF6 PSMA4 PPP3CA PSMA1 PPP3CB PSMA7 BECN1 PSMA8 HRAS PSMB6 NOS2 PSMB7 PSMB4 PSMB5 PSMB2 LRP5 FZD5 EIF2AK2 PSMB3 AMBRA1 PSMB1 APBB1 FZD2 PSMA2-1 PSMC3 PSMC1 ATG101 RYR3 CDK5R1 INS;INS-IGF2 PPIF PPID RTN3 PSMD14 KLC1 KLC4 KLC3 KLC2 MAP2K2;MAP2K1 NAE1 SEM1 MCU ATP2A1 ADRM1 SLC25A31 MAPK10 HSD17B10 KIF5A BACE1 KIF5C PSENEN APP NCSTN PSEN2 GAPDH-1 MAPT PSEN1 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260710%WP4628%HOMO SAPIENS Aerobic glycolysis augmented LDHA PGK1 TPI1 PGAM2 PKM GPI ALDOA GPT ENO1 SLC2A1 PFKM HK1 GAPDH-1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260710%WP5130%HOMO SAPIENS Th17 cell differentiation pathway RUNX1 SOCS3 MAPK8 STAT6 NR1D1 STAT5A IL21R IL21 JUN CD4 IL22 IL2RA MAPK14 CD3G CD3E IL2 CD247 IL23R IFNGR1 IL6 IL27RA IRF4 FOXP3 NFIL3 HIF1A SMAD2;SMAD3 RORA TBX21 IL1B PLCG1 NFKB1 JAK2 RORC IL27 AHR IL23A IL17F CRY1 IL17A PPP3CA RARA CLOCK GATA3 RXRA TGFB1 ARNTL STAT3 IL4 IL6R HLA-DMA NFATC1 IKBKB CD3D MAPK1 PER1 PRKCQ MTOR LAT TGFBR1-1 JAK1 ZAP70 HSP90AA1 LCK FOS NFKBIA IL4R IFNG STAT1 TYK2 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260710%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TP53 FOXO1-1 NOS1 CAT TDO2 TNF EIF2AK1 QPRT IFNB1-4 AADAT EIF2AK4 CDKN1A HAAO ACMSD IL1R2 KYNU AFMID KMO IDO2 KLF5 IDO1 AHR IFNG TLR4 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260710%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging FOXO1-1 FOXO3 HIF1A NAMPT NFKB1 ROS1 SIRT3 PARP1 TFAM-1 SIRT1 PPARG FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260710%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 CCR5 FLT3 STAT3 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260710%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals MAPK8 GSTA3;GSTA5;GSTA1;GSTA2 KEAP1 HMOX1 PRKCA PIK3CA EPHB2 MAF NFE2L2 SLC7A11 NQO1 AIMP2 GCLC GCLM CEBPB COCAINE METABOLISM%WIKIPATHWAYS_20260710%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CES2 CES1 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260710%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260710%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PPP3CA DYRK2 CD8A RASA1 CTLA4 CSNK1A1 IL2 PDK1 PDCD1 RASGRP1 AKT1 PTPN6 CD8B;CD8B2 FYN GSK3A PRKCA DYRK1A NFATC2 PLCG1 NFKB1 ITK CD28 ZAP70 CALM1 LCK NFKBIA GSK3B PTEN METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260710%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 TAR SYNDROME%WIKIPATHWAYS_20260710%WP5362%HOMO SAPIENS TAR syndrome EGFR CD160 ANKRD35 FURIN EIF4A3 SLC22A12 SLK SUMO2 PDZK1 CFTR SLC22A4 GPR89A;GPR89B PEX11B CLCN3 CD247 SLC9A3R1 MAGOH;MAGOHB FARP2 UBE2I HAMP BRF1 PYM1 PIAS3 PDZK1IP1 MITD1 TXN HJV AKAP10 PEX19 NFKB1 ITGA10 MET ZFHX3 RBCK1 LAMTOR1 POLR3GL POLR3C POLR3F POLR3G STAT3 SIRT1 DNM1 ITGB1 CD3D CXCR4 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E FLT3 TNFRSF14 DDIT4 BCL2L13 CCAR2 LCK HDAC2 IFNG MTA1 LUPUS THERAPIES%WIKIPATHWAYS_20260710%WP5560%HOMO SAPIENS Lupus therapies IL17A CD38 CD86 CD80 IL12A IL6 IL6R C1QB C3-1 C2 LOC110384692;C4A;C4B_2;C4B C1QC CD19 IL25 CD40LG IL12B CD22 CD40 CD28 TNFSF13B IL23A IL17F IL17D IFNG IL17C MS4A1 IL17B EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260710%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance FGFR2 EGFR BCL2L11 EIF4E SHC4 CCND1 KDR RPS6 IL6 BCL2 ARAF BAX MYC BCL2L1 NRG2 PDGFA RAF1 IGF1R AKT2 AKT3 AKT1 RRAS2 FOXO3 MRAS EIF4E2 SHC3 PIK3R2 NRG1 SHC2 HGF PDGFB BRAF PLCG1 MET GRB2 JAK2 VEGFA FGF2 GSK3B PTEN PIK3CD RPS6KB2 PIK3CB HRAS SOS2 PDPK1 PDGFRB ERBB2 PRKCB PIK3CA STAT3 GAB1 PIK3R3 BAD SOS1 PIK3R1 GAS6 NRAS IL6R EIF4EBP1 SRC MAP2K2;MAP2K1 IGF1 MAPK1 MAPK3 AXL NF1 KRAS MTOR TGFA RPS6KB1 SHC1-1 JAK1 PDGFD PRKCA PDGFC PRKCG PDGFRA FGFR3 ERBB3 PLCG2 RRAS EGF CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2406%HOMO SAPIENS Cardiac progenitor differentiation TBX20 SOX1 IRX4 TBX5 ZFP42 KDR ROR2 MAPK14 MESP1 THY1 BMP1 NRG1 SOX2 SOX17 WNT3A NODAL MEF2C DKK1 FGF2 GSK3B MYLK3 POU5F1;POU5F1B NOTCH1 GATA4 NKX2-5 TGFB1 ACTC1;ACTG2 INS;INS-IGF2 SIRPA;SIRPB1;SIRPG TNNI3 NANOG;NANOGP8 MESP2 TBXT IGF1 SCN5A CXCR4 BMP4 LIN28B LIN28A ANPEP TNNT2 MYL2 NCAM1 PAX6 KIT MYH6 ISL1 IGF2 NOG PDGFRA MIXL1 FOXA2 INHBA EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260710%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system XPO1 EIF5A;EIF5AL1 IGF2BP1 XPO4 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260710%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease CEBPA SOCS3 TNF PPARA ADIPOQ ATF4 COX6A1 CYP2E1 COX6B1 PKLR CCL13;CCL2 CXCL8 VCAM1 NDUFA4L2 MAP3K11 ITCH ADIPOR1 COX7B NDUFB10 GSK3B COX4I1 PRKAG1 UQCRFS1 PIK3CD RAC1 PRKAG2 NDUFS8 UQCRC1 PIK3CB COX7C NDUFS3 UQCRC2 PRKAG3 UQCRB PRKAB2 SREBF1 UQCR11 PRKAB1 UQCR10 CYC1 COX8A PIK3CA NDUFV1 PRKAA1 PRKAA2 NDUFA9 PIK3R3 NDUFA4 PIK3R1 IL6R UQCRQ RELA SDHA COX5B COX5A COX6C FASLG ADIPOR2 MAP3K5 NDUFA13 NDUFA11 NDUFA12 NDUFA10 COX6A2 TRAF2 SDHC NDUFC1 TNFRSF1A SDHD NDUFS7 NDUFS6 NDUFS4 SMAD7 NDUFS2 NDUFS1 MAPK8 BCL2L11 NDUFB9 NDUFB8 BAK1 NDUFB7 COX7A2L-1 BID NDUFB11 NDUFB6 NDUFB5 JUN NDUFB4 NDUFB3 NDUFB2 NDUFB1 COX7A2 IRS1 IL6 FAS NDUFC2;NDUFC2-KCTD14 BAX NDUFV3 NDUFV2 NR1H3 AKT2 AKT3 COX6B2 COX7B2 NDUFA8 MLX AKT1 COX8C NDUFA7 MLXIP NDUFA6 CYCS-1 NDUFA3 CASP7 CASP8 CASP3 NDUFAB1 PIK3R2 NDUFS5-1 GSK3A INSR IL1B NFKB1 XBP1 EIF2AK3 EIF2S1 ERN1 DDIT3 BBC3 NR1H4 RXRA MAPK9 TGFB1 INS;INS-IGF2 IKBKB CDC42 SDHB LEPR LEP NDUFA5 IL1A COX4I2 IRS2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260710%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS3 SOCS1 HRAS CISH STAT5A STAT5B STAT3 IFNGR1 IL6 CCND3 NRAS CCND2 IL6R IFNGR2 EPO AKT2 FOXM1 AKT3 AKT1 EPOR KRAS MTOR PRLR MLST8 JAK2 GHR AKT1S1 PRL STAT1 IFNG RPTOR SOCS2 CDK4 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260710%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PIK3CD PIK3CB HRAS ARRB1 ARRB2 PRKCB PIK3CA FSHR PLCB3 PLCB4 NRAS PLCB1 PLCB2 PRKCD MAP2K2;MAP2K1 RAF1 MAPK1 PDK1 AKT2 PRKCE MAPK3 AKT1 PRKCQ KISS1R KRAS PRKCA GDF9 MMP9 KISS1 PRKCG NFKB1 CYP11A1 PRKCH HSD3B1;HSD3B2 STAR AMH PIK3CG BMP15-1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260710%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis ITGAV HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FCRL3 PTPN22 TRAF1 PADI4 CD244 PHF19 IRF5 IL2RA SLC22A4 CIITA CTLA4 CD40 BLK CCR6 STAT4 IL6ST SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260710%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity ACE2 IKBKE TRAF3 IFNB1-4 JAK1 TBK1 TLR3 IFNAR2 DDX58 IFIH1 STAT2 TICAM1 IRF3 IFNAR1 STAT1 IRF9 TYK2 MAVS INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260710%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide BECN1 NFKB1 TNF IRF3 MYD88 IFNB1-4 TLR9 IFNG TRAF6 TLR4 MAP1LC3A ESTROGEN METABOLISM%WIKIPATHWAYS_20260710%WP697%HOMO SAPIENS Estrogen metabolism UGT1A1;UGT1A6 CYP1A2 CYP1A1 GSTM1;GSTM2-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ARSD-1 STS ARSL COMT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 GSTA3;GSTA1 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260710%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia ABCG2 FOXO3 GADD45A PIM1 ABL1 PIM2 BCR KIT PDGFRB SKP2 CSF1R FLT1 NOP2 SPRED2 PDGFRA MYC CDKN1B ABCB1 LYL1 GAB2 IL7 SIGNALING%WIKIPATHWAYS_20260710%WP205%HOMO SAPIENS IL7 signaling AKT1 IL7 IL2RG FYN STAT5A PTK2B STAT5B PIK3R2 JAK1 STAT3 BAD PIK3R1 IL7R MAP2K2;MAP2K1 MAPK1 JAK3 STAT1 GSK3B MAPK3 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260710%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway TUBA8 HSPA1A;HSPA1B HSPA6 HSPA2 UBE2J2 HSPA1L PSMC6 PSMC4 CCNE1 SIAH1 FBXW7 PSMD2 PSMD12 PSMD13 CASP8 UBE2J1 PSMD5 RNF19A HSPA14 PSMD9 PSMD10 PSMD6 CUL1 PSMD4 PSMD3 PSMD1 HSPA5 UBA1 PSMC2-1 HSPA4 SIAH2 SNCAIP STUB1 UBE2L6 SEPTIN5 GPR37 UBE2G1 UBE2G2 PSMD8 PSMD7 CASK PSMC3 PSMC1 PSMD11 PSMD14 TUBAL3 HSPA8 TUBA1C TUBA1A TUBB1 PSMC5 SNCA TUBA3E;TUBA3C-1 HSPA9 TUBB2B;TUBB2A PRKN TUBB4B CASP1 TUBA4A TUBB4A;TUBB;TUBB8B;TUBB8 TUBB3;TUBB6 INSULIN SIGNALING%WIKIPATHWAYS_20260710%WP481%HOMO SAPIENS Insulin signaling EGR1 FOXO1-1 CBL KIF5B SOCS3 SOCS1 GRB10 PTPN11 CAP1 TSC1 REG1B;REG1A RAF1 IGF1R MAP3K9 IRS4 CBLC CBLB RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA2 MAP3K8 LIPE MAP3K6 MYO1C SHC2 MAP3K10 MAP3K13 MAP3K11 MAP3K12 PFKL GYS1 FLOT1 FLOT2 MAP4K1 MAP4K2 SLC2A1 MINK1 SLC2A4 PFKM RHOQ MAP4K5 GSK3B MAP4K3 RPS6KA1 PTEN STX4 MAP4K4 MAP3K2 STXBP2 PIK3CD RAC1 MAP3K3 PTPN1 RPS6KB2 PIK3CB SRF RHOJ RPS6KA5 PIK3CA PRKAA1 GAB1 PRKAA2 PIK3R3 SNAP25 GYG1 PIK3R1 EIF4EBP1 PRKCD PTPRF MAPK1 SH2B2 RAB4A MAPK3 RHEB PRKCQ SGK1-1 MTOR PPP1R3A RPS6KB1 ELK1 ENPP1 MAP3K5 PRKCI GYS2 MAP2K3 PRKCH MAP2K4 PRKCZ SGK3;C8orf44-SGK3 SNAP23 FOS MAPK8 GRB14-1 EIF4E MAP2K7 MAP2K6 JUN MAPK14 MAPK12 MAPK13 MAPK11 IRS1 MAP3K7 MAP3K4 AKT2 VAMP2 AKT1 PIK3R4 FOXO3 SHC3 TSC2 ARF6 PIK3R2 GSK3A STXBP1 MAP2K5 INPP4A STXBP3 STXBP4 RRAD INSR EHD1 ARHGAP33 EHD2 GRB2 XBP1 CYTH3 PIK3C2G PIK3C2A PIK3CG HRAS PIK3C3 SOS2 PDPK1 MAPK9 PRKCB RAPGEF1 MAP3K1 ARF1 KIF3A MAP3K14 SOS1 CRK TBC1D4 MAPK7 MAP2K2;MAP2K1 IKBKB MAPK6 MAPK4 TRIB3 SORBS1 MAPK10 SHC1-1 PRKCA INPPL1 IRS2 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260710%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ALDH7A1 ACY1;ABHD14A-ACY1 ADHFE1 GCDH D2HGDH MDH2 L2HGDH IDH2 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260710%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome FNTA LMNA CFB ICMT C3-1 CFD C5 RCE1 LMNB2 LMNB1 NEPHROGENESIS%WIKIPATHWAYS_20260710%WP5052%HOMO SAPIENS Nephrogenesis JAG1 TCF21 RSPO3 RSPO1 WNT9B ALDH1A2 FOXD1 OSR1 FGF20 NOTCH2 WNT4 WNT3A PAX2 BMP7 SIX2 MEIS1 FGF8 GREB1L PDGF PATHWAY%WIKIPATHWAYS_20260710%WP2526%HOMO SAPIENS PDGF pathway RAC1 MAPK8 SRF HRAS TIAM1 PDGFRB PTPN11 RASA1 JUN VAV2 STAT3 MAP3K1 PIK3R1 SOS1 CHUK SRC MAP2K2;MAP2K1 PDGFA PAK1 RAF1 WASL MAPK1 VAV1 CDC42 MAPK3 SHC1-1 JAK1 ELK1 PDGFB PLA2G4A RHOA PLCG1 NFKB1 GRB2 MAP2K4 FOS NFKBIA ARFIP2 STAT1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260710%WP474%HOMO SAPIENS Endochondral ossification CTSV;CTSL STAT5B HMGCS1-1 FGFR1 PLAT PTH1R CDKN1C FGF18 PLAU MGP SOX6 IGF1R ADAMTS1 AKT1 BMPR1A COL10A1 GLI3 MMP13 MMP9 DDR2 THRA ACAN CHST11 CALM1 TGFB2 MEF2C VEGFA FGF2 RUNX2 ADAMTS4 ADAMTS5 NKX3-2 PTHLH FRZB SCIN TGFB1 IHH TIMP3 KIF3A IFT88 HDAC4 SERPINH1 PTH IGF1 PRKACA-1 BMP6 CAB39 SOX9 PTCH1 SOX5 IGF2 RUNX3 ALPL ENPP1 BMP7 COL2A1 SLC38A2 FGFR3 GHR SPP1 STAT1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260710%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 JUN EHMT1 CDKN2A H2BC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 IGFBP7 H2AB2;H2AB3;H2AB1 IL6 RPS27A CDC23 RPS6KA3 CDC27 RPS6KA2 ANAPC7 CXCL8 UBE2D1 ANAPC4 ANAPC5 H2AC4 ANAPC1 ANAPC2 NFKB1 ANAPC10 ANAPC11 CDKN1B CDK2 RPS6KA1 CDC26 ANAPC15 ANAPC16 UBE2S H3-3A CDC16 STAT3 CCNA1 RELA MAPK7 UBE2E1 MAPK1 UBB;UBC FZR1 MAPK3 CEBPB EHMT2 CDKN2D H2AC14 UBA52 H2BC21 H4C1 H4C6 IL1A CDKN1A H4-16 H2AZ2;H2AZ1 CCNA2-1 H2AJ UBE2C FOS CDKN2B CDKN2C CDK6 CDK4 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260710%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNLRB1 DYNC1I1 DYNC1I2 DYNC1LI2 DYNLT2B DYNC2I2 DYNC2I1 DYNC2H1 HSPB11 DYNC1H1 WDR35 DYNC2LI1 IFT80 DYNC1LI1 WDR19 IFT122 DYNLT1 IFT81 IFT43 IFT140 IFT46 IFT22 IFT27 DYNLRB2 IL11 SIGNALING%WIKIPATHWAYS_20260710%WP2332%HOMO SAPIENS IL11 signaling IL11 IBSP SOCS3 HRAS PIAS1 PDPK1 ICAM1 ITGA2 PTPN11 TGFB1 FES STAT3 RPS6 CREB1 PTPA PIK3R1 CHUK BCL2 SRC RELA PIAS3 MAP2K2;MAP2K1 IKBKB RAF1 MAPK1 IL6ST MAPK3 AKT1 FYN IL11RA RPS6KB1 PIK3R2 JAK1 YES1 GRB2 ATF1 JAK2 BIRC5 STAT1 RUNX2 TYK2 RPS6KA1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260710%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP304%HOMO SAPIENS Kit receptor signaling CBL MAPK8 SOCS1 GRB7 STAT5A GRB10 STAT5B PTPN11 EP300 MAPK14 RPS6 RAF1 AKT1 FOXO3 RPS6KA3 LYN PIK3R2 INPP5D PLCG1 KITLG GRB2 JAK2 CRKL BTK TEC RPS6KA1 HRAS MATK SOCS6 PRKCB MITF STAT3 BAD DOK1 SOS1 PIK3R1 CRK SRC MAP2K2;MAP2K1 MAPK1 SH2B2 VAV1 MAPK3 PTPN6 KIT FYN RPS6KB1 SHC1-1 PRKCA GAB2 STAT1 MAPT OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260710%WP5093%HOMO SAPIENS Opioid receptor pathways RGS4 RAC1 NOS2 TNF GATA4 RGS9 ARC MAP1LC3B2;MAP1LC3B-1 JUP CACNA1B RELA BDNF HSPA8 SQSTM1 PRKCE OPRM1 GNAI2 PGM1 GNA12 HMOX1 OPRL1 MBP DNMT3A ALDH9A1 NEU2 PRKCG TUBB4A;TUBB;TUBB8B;TUBB8 E2F1 RPLP2 ADCY1 HDAC1 ADCY8 PIK3CG TLR4 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260710%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence TP53 AKR1B1 SIRT1 MAPK11 ALOXE3 PTGES2 GGT5 GPX1 PTGES3-1 ALDH1A1 ALOX5 ALOX15 HPGD ALOX12 HPGDS SERPINE1 LTC4S PTGS1 FADS2 SLCO2A1 LTA4H GGT1 RB1 PTGDS FADS1 CDKN1A PTGIS ELOVL5 ELOVL2 ALOX5AP DPEP2 CYSLTR1 PLA2G4A ALOX15B DECR1 TBXAS1 GSTP1 DPEP1 PTGS2-2 PTGES ABCC4 PRXL2B EPHX2 CBR1-1 PTGR2 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SRD5A2 SRD5A1 CYP11B1;CYP11B2 HSD11B1 HSD11B2 AKR1D1 CBR1-1 CYP21A2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260710%WP4565%HOMO SAPIENS Neural crest cell migration in cancer PIK3CD RAC1 PIK3CB TIAM1 JUN PIK3CA STAT3 EPHB6 PAK5 ARF1 PIK3R3 EPHB1 EPHB3 MMP8 PIK3R6 NGEF BUB1B-PAK6;PAK6 NTRK2 BDNF PAK1 NGFR TRIO AKT2 PAK3 AKT3 PAK2 KIDINS220 F2RL2 PAK4 PIK3R4 AKT1 PIK3R5 CDH11 MMP9 RHOA EPHB2 EPHB4 SORT1 MMP2 FOS PIK3CG CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260710%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways PHGDH EGFR PSPH TPI1 CREBBP GRB10 VHL KDR EP300 ZEB1 PKM TSC1 ALDOC ALDOB BAP1 ALDOA SQSTM1 ME1 SHMT2 SHMT1 KSR1 AKT1 LDHB SSPN HIF1A LDHA ACACA PGK1 ENPP3 PGM1 RAPGEF5 TSC2 PKLR MDH1 FLT1 MAP2K5 BHLHE41 PDGFB LDHA;LDHC PFKL FASN PSAT1 SLC2A1 PFKM HK2 VEGFA PFKP HK1 DEPTOR RPTOR PTEN KDM5C EFCAB3 PDGFRB PLOD2 PGM2 PBRM1 TOX2 STAT3 SDSL CEP290 ARNT ACACB PGBD5 LDHD KCNJ2 ACLY SETD2 RHEB SDS MTOR CDH13 CAMK1 MLST8 GPI ENO1 PDGFRA ENO2 ENO3 AKT1S1 HK3 GAPDH-1 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ZP2 ERBB2 ANKRD39 LMAN2L NCAPH PARL ADRA2B CIAO1 FAM178B ITPRIPL1 TMEM127 DUSP2 CIAO2B CNNM3 MAPK1 CIAO2A CNNM4 FER1L5 STARD7 MAPK3 SEMA4C ASTL NEURL3 KANSL3 PLXNB2 SNRNP200 MMS19 RHOA COL2A1 COX11 ANKRD23 ADIPOGENESIS%WIKIPATHWAYS_20260710%WP236%HOMO SAPIENS Adipogenesis CEBPA FOXO1-1 SOCS3 SOCS1 LMNA TNF STAT6 BSCL2 STAT5A STAT5B LPIN3 CFD PPARA CEBPD PNPLA3 ADIPOQ FZD1 STAT2 SFRP4 MBNL1 EBF1 KLF15 IRS4 HIF1A GADD45A BMP1 PCK1 PCK2 LIPE PTGIS E2F4-1 EPAS1 AHR SLC2A4 CYP26A1 MEF2A RARA GADD45B MEF2D MEF2B;BORCS8-MEF2B FRZB SREBF1 GATA2 STAT3 CYP26B1 CREB1 RBL1 NCOA1 PPARD IL6ST EGR2 NRIP1 PPARGC1A NCOA2 SERPINE1 RB1 CDKN1A E2F1 OSM STAT1 LIF HNF1A DLK1 RXRG LPL ID3 CNTFR IRS1 IL6 FAS LPIN2 NR1H3 WNT5B SCD DVL1 SMAD2;SMAD3 RORA NDN WNT1 AGT WNT10B RBL2 RETN MEF2C DDIT3 NR2F1 ASIP NCOR2 CISD1 GATA3 NCOR1 RXRA GATA4 CELF1 TGFB1 GDF10 INS;INS-IGF2 PLIN1 NAMPT IGF1 UCP1 SP1 BMP4 AGPAT2 MIF BMP3 CEBPB BMP2 TRIB3 LEP GTF3A PLIN2 SPOCK1 LIFR KLF7 PRLR KLF6 NR3C1 LPIN1 FOXC2 WWTR1 ZMPSTE24 KLF5 MIXL1 IRS2 CTNNB1 PPARG CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260710%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis PPP3CA PPP3CB CD8B;CD8B2 MEF2D CD8A ITPRIP CD4 NR4A1 EP300 NFATC2 PLCG1 ZAP70 CALM1 LCK HDAC2 CABIN1 ATP2A1 PPP3CC HDAC1 CAPN2 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260710%WP500%HOMO SAPIENS Glycogen synthesis and degradation PPP2R5E PPP2R5C PHKA2 GBE1 GYG2 PTPA GYG1 CALM3;CALM1 PHKG2 CALM2 PPP2CB;PPP2CA PPP2R5B PYGL PPP2R5A PPP2R1B UGP2 PGM1 PPP2R2A;PPP2R2D GSK3A PYGB PYGM PHKG1 PHKB PHKA1 PPP2R1A HKDC1 AGL-1 GYS1 PPP2R3B GYS2 PPP2R3A PPP2R2C CALM1 PPP2R5D PPP2R2B HK2 HK1 HK3 GSK3B GLUCURONIDATION%WIKIPATHWAYS_20260710%WP698%HOMO SAPIENS Glucuronidation UGT1A1;UGT1A6 PGM5 UGT2A1 UGP2 PGM1 UGDH UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM2 HK1 PGM3 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260710%WP288%HOMO SAPIENS Nod like receptor NLR signaling EPHB2 MAPK8 CD40 CHUK RELA IKBKB MAP3K7 ERBIN IKBKG DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260710%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR TP53 HERC2 PCNA MDC1 EXO1 MCPH1 RMI1 TP53BP1 TOP3A RAD17 POLN TRIM28 UPF1 MSH2 MDM2-2 XPA RNF8 FANCD2 CHEK2 CHEK1 RPA2 MRE11 CDC25C RPA1 BRCA2 UBE2D3-1 RAD52 BRCC3 RAD50 RAD51 NBN PRKDC USP1 BARD1 BCL6 ATM RFWD3-2 SMARCC2 BRIP1 CDK2 CLK2 FANCI RAD9A SMARCAL1 CEP164 BRCA1 PLK1 FANCA TDP1 UIMC1 PALB2 PARP1 PML FEN1 ATR PPM1D POLB SMC1A RBBP8 HUS1 RAD1 TOPBP1 ABRAXAS1 SEM1 ATRIP MLH1 SP1 MCM2 FOXM1 IKBKG CDC45 CDK1 WRN DCLRE1A RECQL XRCC5 EEF1E1 RECQL5 CLSPN E2F1 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260710%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDHA BCKDK PDHA1 TPK1 SLC25A19 SLC19A2 SLC19A3 TKT OGDH MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260710%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling EGR1 FN1 SOCS3 SOCS1 PCNA TNF CDH1 KLK15 KDR NR4A1 ZEB1 FZD1 RPS6 COL4A1 RAF1 IGF1R DUSP1 LDHA ACACA RPS6KA4 RPS6KA3 CLDN5 CCL13;CCL2 CXCL8 SIX1 CXCL5;CXCL6 PLCG1 CXCL2;CXCL3;CXCL1-1 CRKL SLC2A1 HK2 NDRG1 GSK3B RPS6KA1 PTEN CDH2 RPS6KA5 PARP1 DUSP6 GAB1 PRKAA2 PIK3R1 HSPB1 RELA CSF2 MAPK1 CXCL10 MAPK3 PPARGC1A MTOR TJP1 RPS6KB1 VIM ELK1 ZEB2 PDGFRA DUSP4 FOS TP53 SMAD6 IBSP MAPK8 IFNB1-4 JUN MAPK14 FGFR1 IL6 CPT1A AKT1 SMAD2;SMAD3 FLT1 MST1R WNT10B MMP9 PTK2 IL1B NFKB1 GRB2 VEGFA SNAI2 PDPK1 PDGFRB MAPK9 IL10 PRKCB TGFB1 ITGB1 SMAD1 SMAD9 SRC CSF3 MAP2K2;MAP2K1 SMAD5 ACTA2 CLDN1 MST1 OCLN-1 ABL1 SP7 PDCD4 SHC1-1 CTNNB1 SLPI NR0B2 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260710%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 RBBP4 EZH1 THRAP3 SETX BCLAF1 SUZ12 AEBP2 MTF2 EED EZH2 RBBP7 MORC3 ELL STK38 TRIM35 JARID2 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260710%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling AKT1 APPL1 FOXO1-1 SGK1-1 MTOR RPS6KB2 RPS6KB1 TSC2 PRKCA FSHB CGA MAPK14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RPS6 CREB1 FSHR GRK6 EIF4EBP1 SRC PRKACA-1 RAF1 MAPK1 MAPK3 RHEB FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260710%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260710%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation TUBA1A DCX PAFAH1B3 VLDLR NUDC NDEL1 PAFAH1B2 RELN DYNC1H1 CLIP1 PAFAH1B1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling MAML2 DLK2 MFAP2 NOTCH1 DLK1 HES1 LEF1 CNTN6 JAG2 DLL1 DLL3 CHUK JAG1 ADAM10 MAML1 MFAP1 NOTCH2 NOTCH3 NOTCH4 HEY1 DLL4 MAML3 RBPJ RRAS PSEN2 DNER PSEN1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260710%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CD PTPN6 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PIK3CB PIK3R2 CD86 PTPN11 PIK3CA CD80 CTLA4 PIK3R3 PIK3R1 CD28 PPP2CB;PPP2CA IL17 SIGNALING%WIKIPATHWAYS_20260710%WP2112%HOMO SAPIENS IL17 signaling IL17A IL17RE IL17RC IL17RD IL17RB IL17RA PIK3CA CEBPD STAT3 MAP3K14 RELA IKBKB MAP3K7 MAPK1 SP1 IKBKG MAPK3 CEBPB AKT1 TRAF3 JAK1 IL25 TRAF3IP2 NFKB1 JAK2 NFKBIB IL17F IL17D IL17C GSK3B TRAF6 IL17B ATM SIGNALING%WIKIPATHWAYS_20260710%WP2516%HOMO SAPIENS ATM signaling MDM4 TP53 RAD9A BRCA1 MDC1 MAPK9 BID JUN SMC1A CCNB1 PIDD1 TP53BP1 CREB1 CDC25A CCNE1 MDM2-2 IKBKG GADD45A CHEK2 ABL1 CDK1 TLK1 CHEK1 MRE11 RIPK1 CDC25C ATF2 CDKN1A RAD50 RAD51 NBN CRADD ATM TP73 CASP2 CDK2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260710%WP4666%HOMO SAPIENS Hepatitis B infection NFATC3 HSPG2 PCNA TNF STAT6 STAT5A STAT5B EP300 ATF4 IFIH1 STAT2 RAF1 IFNAR1 APAF1 CREB3 CREB3L3 TRAF3 CREB3L4 CREB3L1 CREB3L2 CREB5 CXCL8 NFATC2 DDB2 DDB1 PIK3CD PIK3CB PIK3CA STAT3 YWHAB CREB1 PIK3R3 IRAK1 PIK3R1 NRAS RELA MAPK1 EGR2 MAPK3 MAVS KRAS TGFBR1-1 MYD88 JAK1 ATF2 CDKN1A FASLG ELK1 CASP10 ATP6AP1 TGFBR2 DDX58 PRKCG MAP2K3 MAP2K4 IRF3 FOS BIRC5 STAT1 TRAF6 DDX3X-1 IRF7 MAPK8 EGR3 MAP2K7 CREBBP PTK2B BID MAP2K6 IFNB1-4 JUN MAPK14 MAPK12 MAPK13 MAPK11 IL6 BCL2 FAS ARAF BAX MYC MAP3K7 AKT2 AKT3 AKT1 CASP9 CYCS-1 SMAD2;SMAD3 ATF6B CASP8 CASP3 PIK3R2 FADD SMAD4 TICAM2 BRAF MMP9 NFKB1 TICAM1 GRB2 JAK2 TGFB2 TGFB3 STAT4 SLC10A1 TAB2 HRAS IKBKE IRAK4 TIRAP SOS2 MAPK9 PRKCB TGFB1 NFATC4 TLR3 MAP3K1 VDAC3 TLR2 BAD SOS1 CHUK SRC NFATC1 MAP2K2;MAP2K1 IKBKB IKBKG YWHAQ MAPK10 TAB1 TBK1 PRKCA YWHAZ JAK3 TYK2 TLR4 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome FMR1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 NIPA1 CYFIP1 TUBGCP2 NIPA2 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260710%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HEY1 HIF1A VEGFB HES1 VEGFC HIF1AN VEGFA WNT SIGNALING%WIKIPATHWAYS_20260710%WP428%HOMO SAPIENS Wnt signaling NFATC3 DAAM2 PRICKLE2 GPC4 CCND1 FZD1 CSNK1A1 FZD7 FZD8 SFRP4 CER1 CTNNBIP1 PPP3R1 KREMEN1 SENP2 SFRP5 CXXC4 NKD1 NKD2 NOTUM FRAT2 NFATC2 CAMK2A VANGL2 GSK3B RAC1 CAMK2B SFRP2 NLK PRICKLE1 CTBP2 CSNK2B LRP6 CSNK2A2 CSNK2A1;CSNK2A3 VANGL1 PRKCG CHD8 FZD6 FZD9 MAPK8 CTBP1 FZD10 RYK-1 ROR1 JUN TPTEP2-CSNK1E;CSNK1E ROR2 CCND3 CCND2 PLAU MYC MAP3K7 WNT5B WNT5A TCF7 WNT6 DVL1 DVL2 DVL3 WNT1 PORCN WNT2 SFRP1 WNT3 WNT4 WNT10B WNT10A SOX17 WNT3A WIF1 DKK4 FOSL1 SOST SERPINF1 DKK2 WNT2B DKK1 PPP3CA AXIN1 PPP3CB WNT16 CAMK2D LEF1 LRP5 MAPK9 FZD5 WNT11 PRKCB FZD2 TCF7L2 TCF7L1 NFATC4 PLCB3 PLCB4 WNT7B WNT7A APC PLCB1 ROCK2 PLCB2 DAAM1 NFATC1 PPP3CC CAMK2G PRKCA FZD3 RHOA INVS CTNNB1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260710%WP4521%HOMO SAPIENS Glycosylation and related congenital defects MOGS ALG12 ALG1 ALG11 DPM1 DPM2 DPM3 DPAGT1 B4GALT1 TUSC3 MPI GMPPB MAGT1 MGAT2 MPDU1 ALG8 PMM2 SRD5A3 ALG9 DOLK ALG6 ALG2 ALG14 ALG3 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260710%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260710%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression AKT1 PIK3CD MTOR MKNK2 PIK3CB MKNK1 EIF4E TSC2 PIK3R2 MAP2K6 PIK3CA PRKAA1 MAP3K11 PIK3R3 TSC1 PIK3R1 MAP3K5 MAP2K3 EIF4EBP1 PBK MAP2K2;MAP2K1 RAF1 MAPK1 MAPK3 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome IQCA1 CALCRL GBX2 HES1 PDX1 TNF RAMP1 DGKD HDLBP HJURP ERFE KLHL30 MAP1LC3B2;MAP1LC3B-1 PASK RPS6 THAP4 AGAP1 COPS9-1 ITPK1 SEPTIN4-1 ESPNL TRPM8 OR6B2 HAMP MTERF4 STK25 SNED1 RTP5 GMEB1 RNPEPL1 IRF8 ING5 LRRFIP1 KIF1A ILKAP COL6A3 AQP12B DUSP28 OTOS ARL4C ATG4B DISC1 USP40 ARF5 TRAF3 ASB18 CENPA CYTH2 CYTH4 ABCA1 SPP2 PRLH CYTH1 SEPTIN6 MAB21L4 RAB17 CXCL11 RBM44 ASB1 GYS1 CALM1 CXCL12 MAP1LC3A MEF2A RAC1 TRAF3IP1 GPC1 PPP1R7 PER2 HDAC4 CXCR4 UGT1A1;UGT1A6 EEF1A1 AGXT RAB27A SEPTIN2 NEU4 NDUFA10 MLPH HES6 TP53 EGFR SCLY JUN CFLAR SH3BP4 FARP2 ASCL1 MYOG PDGFA MYOD1 ITGB3 GABARAPL2 GABARAP ACKR3-2 IL1B DTYMK CYTH3 SEPTIN12 D2HGDH MEF2C ILK PRL COPS8 CALCA GPR35 MAP1LC3C BOK RRAGA RRAGC RRAGB ARF1 RRAGD MYO5A UBE2F PDCD1 CAPN10 IL13RA1 TWIST2 NFKBIA FOLATE METABOLISM%WIKIPATHWAYS_20260710%WP176%HOMO SAPIENS Folate metabolism MPO TP53 F2 SAA2-SAA4;SAA4 F7 TNF APOA1 ICAM1 PLG IL2 PLAT IL6 SHMT2 SHMT1 SOD2 SLC46A1 GPX6 RFK HBD;HBB SOD3 CCL13;CCL2 ABCA1 SOD1 CSF1 IZUMO1R IL1B INSR NFKB1 FOLR2 NFKB2 CTH SCARB1 FLAD1 CAT LDLR IL4 INS;INS-IGF2 RELA GPX1 APOB GPX4 ST20-MTHFS;MTHFS SLC19A1 ALB FOLR1 AHCY MTRR SERPINE1 MTR-1 SAA2;SAA1 HBA2;HBA1 FGB MTHFR FGA MAT1A DHFR2;DHFR FGG MTHFD1 MTHFD2 GART IFNG CBS;CBSL CRP SERPINA3 PURINERGIC SIGNALING%WIKIPATHWAYS_20260710%WP4900%HOMO SAPIENS Purinergic signaling GNAZ GNAO1 GNAS-1 GNAI3 P2RY12 P2RY13 P2RY10 P2RY11 GNAI1 P2RY14 GNAI2 ADORA2B LPAR4 P2RY6 P2RY4 P2RY2 ADORA2A LPAR6 P2RY1 ADORA3 P2RY8 GNA11 GNAT2 ADORA1 GNAT3 PANX1 GNAT1 P2RX7 P2RX5 P2RX6 P2RX4 P2RX3 P2RX2 P2RX1 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260710%WP5390%HOMO SAPIENS Pancreatic cancer subtypes SERPINB3;SERPINB4-1 GPR87 FGFBP1 KRT20 CST6 LYZ-1 LGALS4 CTSV;CTSL TFF3-1 CTSE VSIG2 SPRR1A;SPRR1B AGR2 AGR3 FAM3D SPINK4 S100A2 KRT7 ANXA10 LEMD1 DHRS9 PRR15L CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MYO1A LY6D KRT6B;KRT6C;KRT6A TFF1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 SCEL VGLL1 CLRN3 FAM83A ANXA8;ANXA8L1 TSPAN8 AREG PLA2G10;LOC100652777 CDH17 REG4 KRT15 TNS4 SLC2A1 KRT17 SPRR3 ST6GALNAC1 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260710%WP2366%HOMO SAPIENS Butyrate induced histone acetylation AKT1 ACLY TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260710%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly RBBP4 DAXX ATRX CHAF1B CHAF1A SMIM40 H4C1 HIRA H4C6 H4-16 H2BC15;H2BC3;H2BC11;H2BC12 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260710%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD CYP1A2 EGFR CYP1A1 NCOR2 CCL1 HRAS AHRR TNF LPL EP300 CD36 AIP ARNT NRAS SRC ESR1 RELA PSRC1 MAP2K2;MAP2K1 MYC NCOA7 NQO1 RAF1 MAPK1 GCLC CYP1B1 NRIP1 FGF21 NF1 KRAS CDC37 HPGDS KLF6 RET RB1 CDKN1A PLAGL1 NFKB1 PTGS2-2 NFE2L2 E2F1 HSP90AA1 CDKN1B AHR VEGFA CDK2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260710%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling MAP2K6 MAPK14 RPS6 TSHB CCND3 CCNE1 PLD1 RAF1 IGF1R RAP1GAP TSHR AKT1 MYL12B GNA13 GNA12 PIK3R2 RAP1B GNG2 RAP1A CGA RBL2 BRAF JAK2 CDKN1B PDE4D-1 CDK2 RPS6KA1 HRAS ADCY2 PDPK1 PIK3CA STAT3 RALGDS CREB1 GNAO1 PIK3R1 GNAQ PLCB1 SRC GNAS-1 MAP2K2;MAP2K1 GNAI3 KCNIP3 MAPK1 GNB1 MAPK3 GNAI1 GNAI2 MTOR RPS6KB1 JAK1 RB1 APEX1 SCRIB MAP2K3 ADCY3 STAT1 CDK4 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260710%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells ETS2 EGFR GATA4 CD63 SOD1 STAT3 KDR MMP9 PDLIM5 IL6 CD81 HSPB1 IGF1 SPP1 SORBS2 BIRC5 EGF TLR4 PTEN NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260710%WP4747%HOMO SAPIENS Netrin UNC5B signaling TP53 TNF PTK2B ICAM1 PTPN11 JUN KDR MAPK14 ARHGEF12 DAPK1-1 RAF1 AGAP2 MYF5 AKT1 PPP1CA CASP3 CCL13;CCL2 VCAM1 SELE CDH5 CCN2 INPP5D PTK2 ITGB4 COL1A1 RAC1 NEO1 IL10 PIK3CA PTPA SRC MAP2K2;MAP2K1 UNC5B MAPK1 CIP2A NTN4 NTN1 RLF MAPK3 NTN3 PLEKHH1 PPP2R1B FYN RGMA PRKCA IL1A YAP1-1 RHOA ALPL DCSTAMP ROBO4 PPAR SIGNALING%WIKIPATHWAYS_20260710%WP3942%HOMO SAPIENS PPAR signaling MMP1 RXRA APOA2 FABP1 RXRG PDPK1 APOA1 LPL FABP3 CYP8B1 FABP4 ACAA1-1 APOA5 PPARA ADIPOQ CD36 GK PLTP PLIN1 SLC27A4 HMGCS2 LOC100509620;LOC112267859;AQP7 SCP2 ACSL1 UCP1 APOC3 ACOX1 EHHADH-1 PPARD NR1H3 ME1 UBB;UBC ANGPTL4 SORBS1 CYP27A1 SCD PCK1 FADS2 PCK2 CPT2 SLC27A5 CPT1C SLC27A1 CYP7A1 OLR1 ILK RXRB PPARG CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260710%WP2795%HOMO SAPIENS Cardiac hypertrophic response FGFR2 MAPK8 TNF MAP2K7 MAP2K6 MAPK14 MAP3K7 RAF1 AKT2 PRKD1 AKT1 HDAC5 NRG1 MAP2K5 NFATC2 NFKB1 CDK7 MAP4K1 CALM1 FGF2 PLA2G2A-1 GSK3B PPP3CA RAC1 MEF2A NPPA IKBKE PDPK1 CAMK2D HDAC9 HDAC7 TGFB1 MAP3K1 CDK9 MAP3K14 HDAC4 CHUK MAPK7 MAP2K2;MAP2K1 IGF1 IKBKB MAPK1 IKBKG MAPK3 LOC118142757;GUCA1A MTOR TGFBR1-1 PRKG1 PRKCA MAP2K3 MAP2K4 TNFRSF1A EGF PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260710%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer FOXO1-1 PIK3CB HRAS GRB10 PIK3CA PIK3R3 BAD PIK3R1 MAPKAP1 NRAS EIF4EBP1 RICTOR ULK1 PDK1 RHEB AKT1 FOXO3 KRAS MTOR TFEB TSC2 PIK3R2 NOS3 MLST8 RB1CC1 FOXO4 CDKN1B ATG13 PIK3CG GSK3B RPTOR PTEN IL18 SIGNALING%WIKIPATHWAYS_20260710%WP4754%HOMO SAPIENS IL18 signaling TP53 TNF MAP2K7 BID CFLAR FAS BAX MAP3K7 NOX1 CSN2-1 IL18 CYCS-1 CASP8 CASP3 TICAM2 NFKB1 GSK3B IL18RAP PTEN MEF2A MAPK9 PARP1 PRKCB PRKAA1 ACACB NFATC4 IRAK1 PIK3R1 IL37 HSPB1 CHUK PRKCD RELA IKBKB IRF1 GRIN2B MAPK1 SP1 MAPK3 CEBPB ELAVL1 IMP3 SLC12A3 RPS6KB1 MYD88 PRKCA GATA1 FASLG IL18R1 NCF1 NCF2 LCK CTNNB1 NFKBIA TNFRSF1A TRAF6 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260710%WP4963%HOMO SAPIENS p53 transcriptional gene network PCNA TNF ICAM1 SESN2 TP53INP1 PIDD1 TRAF4 CDC25A SAT1 FAS CCNE1 BAX ULK1 GLS2 MSH2 XPC APAF1 GADD45A ADORA2B TSC2 PMAIP1 CDC25C ERCC5;BIVM-ERCC5 CCL13;CCL2 DDB2 CPT1C FUCA1 SESN1 SLC2A1 ZMAT3 CX3CL1 DEPTOR PERP BBC3 RPTOR CDK2 PTEN TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKAG1 SFN PRKAG2 NOTCH1 FANCC PRKAG3 ALDH4A1 POLK PRKAB2 PRKAB1 PML IRF5 RRM2B POLH PRKAA1 PRKAA2 ULK2 NANOG;NANOGP8 MGMT GPX1 MLH1 TIGAR ISG15 TP53I3 MTOR BTG2 ACAD11 SERPINB5 SERPINE1 SCO2 ADGRB1 ULBP1-2 DRAM1 RPRM ULBP3;ULBP1;RAET1G;ULBP2;RAET1L SIVA1 CDKN1A MLST8 AURKA FASLG DDIT4 CCNG1 XRCC5 E2F7 NCF2 THBS1 SLC7A11 AKT1S1 IRF9 LIF IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260710%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity TIMP2 IL18 HBEGF F2 TLR1 IL1R1 PLA2G7 FCER1A MYD88 ICAM1 CCL13;CCL2 CCR3 PIK3CA TLR2 IRAK1 MMP9 IL1B NFKB1 S100A9 NLRP3 TIMP1 SELENBP1 F2R IFNG AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260710%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG1 PPARGC1A PRKAG2 MTOR PRKAG3 RPS6KB1 PRKAB2 PMAIP1 MDH1 PRKAB1 MLST8 PRKAA1 SIRT1 PRKAA2 RPTOR MAPK3 PARP2 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260710%WP5103%HOMO SAPIENS Progeria associated lipodystrophy FNTA LMNA ICMT SMAD2;SMAD3 BANF1 FBN1 KCNJ6 PARP1 TGFB1 MUCL3 SPRTN SMAD4 INS;INS-IGF2 WRN POLD1 RECQL ZMPSTE24 FFAR3;GPR42 LMNB2 LMNB1 PPARG MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260710%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF3 SDHAF1 SDHAF4 SDHC SDHA SDHD SDHAF2 SDHB MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260710%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 CEBPA ORAI1 EGFR PTPN1 USF1 EIF4E STAT5A STAT5B TNFRSF11A CCND1 ERBB2 NFIB YY1 CHUK USF2 NFIA TPM3 ESR1 NFIC NFIX MYC BCL2L1 GJB2 CEBPB CSN2-1 EIF4G1 PRLR NR3C1 NRG1 PGR ESR2 CAV1 PNCK ERBB4 ATP2C2 TNFSF11 DLGAP4 JAK2 TFPI2 CLDN6 TTC9 ERBB3 GAL ELF5 HDGFL2 PRL SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260710%WP3947%HOMO SAPIENS Serotonin and anxiety PPP3CA EEF2K FMR1 CRH GRM1 HTR2A ARC PRKCB CAMK2B HTR1A POMC ADRA1A PLEK GABRA1 FOS TRPV1 PLCD4 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260710%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway RHOA TP63 IRF6 TFAP2A TGFB3 ARHGEF2 ARHGAP29 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260710%WP4157%HOMO SAPIENS GABA metabolism aka GHB GAD1 ALDH5A1 DPEP1 ABAT GAD2 ADHFE1 AKR7A2 MAOB GLS GLS2 PON3 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260710%WP5087%HOMO SAPIENS Pleural mesothelioma KMT2C TERT CCND1 CDH1 KDR RPS6 TSC1 CCNE1 ULK1 RAF1 CER1 ADAMTS1 KREMEN1 SENP2 SFRP5 HIF1A CXXC4 NOTUM SLC7A5 SLC2A1 RPTOR MEF2D RPS6KA5 BMI1 CREB1 SFRP2 MAPKAPK2 PAK1 CCL5 CSF2 MAPK1 MAPK3 PPARGC1A MTOR TGFA MKNK1 RPS6KB1 PDGFD AREG JAK1 ATF2 PDGFC CDKN1A IGF2 ELK1 FGF7 CASP1 MAP3K5 MAP2K3 MAP2K4 PDGFRA NTF3 MMP2 TRAF2 EGF STAT1 FGF3 CDK4 FGF5 FGF6 MDM4 TP53 HBEGF FGF9 FGFR2 EGFR MAPK8 CTBP1 PGF BAK1 COL4A6 MAP2K7 EFNA5 RYK-1 EFNA4 MAP2K6 MCL1 FGF20 JUN ROR1 CDKN2A TPTEP2-CSNK1E;CSNK1E FGF22 ROR2 FGF17 EFNA1 MAPK14 EFNA3 FGF14 EFNA2 IL6 BCL2 FGF18 BAX FGF13 FGF12 NGFR FGF11 ITGB3 LAMC3 LAMC2 LAMA1 LAMA3 TSC2 PORCN FLT1 CDH5 CCN2 ANGPT4 ANGPT2 HGF MMP9 LAMB3 IL1B MET LAMB1 VEGFA CDK2 IL10 TGFB1 HMGN1 PLCB4 ITGB1 ITPR3 IL34 CSF3 HCFC1 ACTG1 CSF1R FZD3 STK38L TNIK ACTB-1 CTNNB1 NGF AJUBA SUZ12 RNF2 TELO2 IDO1 MAP3K9 BTC CCL13;CCL2 MAD1L1 CXCL5;CXCL6 CUL1 VEGFB LGALS9C;LGALS9;LGALS9B CXCL2;CXCL3;CXCL1-1 VEGFC VEGFD CXCL12 CIT CDH2 CD44 MDK RASSF7 YWHAB PAK5 COL4A4 COL4A3 COL4A5 CSNK2B LAMA5 LRP6 PODXL LAMB2 RASSF1 MMP14 RASSF5 MKNK2 ANGPT1 WDR5 TEK FGFR1 ASXL1 BAP1 BUB1B-PAK6;PAK6 FGF8 AKT2 AKT3 AKT1 MAP2K5 TTI1 SOX17 PTK2 DKK4 GRB2 ITGB4 ITGB2 DDIT3 ITGAV HRAS ITGA4 ITGA3 PDGFRB FZD5 ITGA2 ITGA1 FZD2 ACTC1;ACTG2 ITGA6 FLT4 SOS1 CDH9 CDH8 CDH7 CDH6 SRC SETD2 CDH4 MAPK7 MAP2K2;MAP2K1 CDH3 TEAD1 TEAD2 TEAD3 CD274 ACTA2 TEAD4 PAK3 PAK2 ACTA1 MST1 PAK4 LATS1 KDM6A LATS2 TNNT1 MAPK10 CDH10 CDH11 KIT CDH12 SHC1-1 CDH13 CDH15 CDH16 CDH17 CDH19 EPHA2 STK3 YAP1-1 CDH20 CDH22 CDH24 WWTR1 NF2 FGFR3 FN1 FABP4 LAMA4 LAMC1 COL4A2 COL4A1 RPS6KA3 CCL4L2;CCL4L1;CCL4 MAP3K6 FRAT2 MAP3K10 MAP3K11 MAP4K1 MAP4K2 MINK1 FGF2 DEPTOR MAP4K3 GSK3B PTEN MAP4K4 PRKAG1 MAP3K2 PIK3CD MAP3K3 PRKAG2 RPS6KB2 PIK3CB PRKAG3 PRKAB2 PRKAB1 PIK3CA PRKAA1 PRKAA2 NLRP3 EIF4EBP1 CTBP2 NTRK2 BDNF CXCL10 RHEB SPARC MLST8 AKT1S1 PHC1 PRSS23 RING1 DSC3 RBBP4 BAG2 FZD6 RASSF2 FZD9 RASSF3 RASSF4 RASSF6 MAD2L1 NTRK1 FZD10 UHRF1 CCND3 CCND2 PLAU MYC MAP3K4 PDK1 WNT5B WNT5A MDM2-2 TCF7 EIF4G1 WNT6 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A WNT3A INSR NFKB1 FOSL1 ATM WNT2B PIK3CG BBC3 AXIN1 WNT16 LEF1 MAPK9 WNT11 HMGB1-1 TCF7L2 TCF7L1 MAP3K1 WNT7B WNT7A SLC3A2 APC ULK2 SP1 LIN28B FOXM1 VGLL4 CD47 SAV1 AMOT AGER LAMA2 FOXO1-1 CTNNA1 CTNNA3 CTNNA2 FZD1 CSNK1A1 FZD7 FZD8 SFRP4 FGF1 IGF1R MAX PDGFB CDK7 BARD1 KITLG FGF19 FGFR4 NDRG1 RPS6KA1 BRCA1 CDH18 EED SETD5 MOB1A;MOB1B SETDB1 CSNK2A2 CSNK2A1;CSNK2A3 WWC1 FGF23 KIF23 E2F1 BTRC PIGF CHD8 OGT-1 LIMD1 EZH2 PDGFA FGF4 NTF4 FLT3LG FGF10 CYCS-1 SFRP1 MMP3 CSF1 SELE RB1CC1 WIF1 SOST SERPINF1 DKK2 DKK1 ATG13 BECN1 LRP5 INS;INS-IGF2 YY1 CTHRC1 IGF1 MCU FGF21 ATF3 EIF4B FLT3 GABPA EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260710%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer FN1 WNT8A TMPRSS4 FOXQ1 SUZ12 CDH1 ZEB1 FZD1 JUP JAG2 FZD7 DLL1 FZD8 DLL3 COL4A2 COL4A1 RAF1 HIF1A CLDN5 NOTCH3 NOTCH4 DLL4 GSK3B NRP2 PIK3CD PIK3CB MEF2D CDH2 CLDN7 PIK3CA EED PIK3R3 PIK3R1 COL4A4 COL4A3 COL4A5 CLDN3 PAK1 MAPK1 LRP6 VTN MAPK3 SPARC JAG1 KRAS TJP1 TGFBR1-1 TGFBR2 ZEB2 MAP2K3 MAP2K4 CLDN6 MMP2 TRAF6 CLDN4 TP53 RBBP4 FZD6 FZD9 MAPK8 DLK1 COL4A6 WNT9B PDCD6 FZD10 CLDN2 CDKL2 MAP2K6 CLDN9 PKD1 CLDN8 WNT9A PKP1 EIF5A2 CLDN23-1 ID2-1 MAPK14 EZH2 CLDN20 WNT8B NUBPL MAPK12 TUSC3 CLDN22;CLDN24-1 CLDN10 MAPK13 CLDN15 MAPK11 CLDN14 CLDN12 CLDN19 PROX1 STRAP CLDN18 CLDN17 FMNL2 CLDN16 CRB3 AKT2 WNT5B AKT3 WNT5A AKT1 WNT6 SMAD2;SMAD3 PIK3R2 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A SMAD4 WNT3A MMP9 GRB2 TGFB2 WNT2B TGFB3 NR2C2 SNAI1 SNAI2 WNT16 NOTCH1 HRAS SOS2 LRP5 FZD5 WNT11 FZD4 TGFB1 FZD2 CTDSP1 MMP15 ITGA5 WNT7B SOS1 WNT7A MAP2K2;MAP2K1 CLDN1 FOXM1 LATS2 MPP5 OCLN-1 TWIST2 SHC1-1 NOTCH2 FZD3 FOXC2 DSP CLDN11 ID1 RBPJ CTNNB1 PKP2 GDF15 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260710%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members CREBBP PARP1 EP300 MAP3K14 CHUK IKBKB ZC3HAV1 TIPARP PARP16 IKBKG PARP12 MAVS PARP14 SKP1 TBK1 RBX1 DDX58 CUL1 NFKB2 RELB TFPI2 CLDN6 EIF2AK3 BTRC ERN1 NFKBIA PARP10 GSK3B CYTOSINE METHYLATION%WIKIPATHWAYS_20260710%WP3585%HOMO SAPIENS Cytosine methylation DNMT1 TDG MECP2 TET1 MBD3 TET2 IDH1 IDH2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260710%WP3995%HOMO SAPIENS Prion disease pathway CTCF RXRA STAT3 EP300 CREB1 SPI1 FGFR1 BCL2 HSP90B1 IRF4 MAPK1 POU2F2 BATF MAPK3 PDIA3 EBF1 SMC3 RFX5 NCAM1 PAX5 FYN CASP3 CHD2 TBP ELK1 PTK2 NFKB1 HSPA5 PRNP MEF2C BCL11A RAD21 FANCONI ANEMIA%WIKIPATHWAYS_20260710%WP5465%HOMO SAPIENS Fanconi anemia FANCI FANCM EGFR FANCL SMARCA4 BRCA1 FANCA FANCC FANCE PALB2 FANCG UHRF1 SLX4 FANCF ATR CEBPD RAD51C UBE2T FAAP24 LOC105377022;FANCB HSP90B1 CENPX CTDP1 MCM2 DCLRE1B FANCD2 UHRF2 FAN1 MEN1 MAD2L2 MRE11 BRCA2 RAD50 RAD51 NBN USP1 ERCC4 XRCC2 ERCC1 FAAP100 ATM REV1 RFWD3-2 CENPS-CORT;CORT;CENPS BRIP1 PTEN THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260710%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PLCD1 TRH PRKAA1 PRKAA2 TPO CREB1 MAP2K2;MAP2K1 SLC5A5 RAF1 MAPK1 DUOX2 MAPK3 TSHR TG DUOX1 ANO1 CLCN5 SLC26A6 RAP1B RAP1A PRKCA CGA ELK1 NFKB1 ACY1;ABHD14A-ACY1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling MAPK8 HRAS PTK2B ITGA1 PTPN11 RASA1 JUN PIK3CA STAT3 RAPGEF1 GAB1 ITGB1 SOS1 CRK DOCK1 SRC MAP2K2;MAP2K1 PAK1 RAF1 MAPK1 MAPK3 PXN RAP1B RAP1A ELK1 HGF PTK2 MET GRB2 PTGS2-2 MAP4K1 CRKL FOS PTEN LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260710%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions RAC1 FOXO1-1 RASSF5 LPL MAPK14 PRDM1 TEAD1 TEAD2 TEAD3 FOXP3 TEAD4 MST1 MOB1A;MOB1B LATS1 LATS2 FOXO3 YWHAQ FOXO6 CCR7 KNSTRN-1 FYB1 RAB13 RAP1A CD19 FERMT3 STK3 YAP1-1 RHOA SAV1 STK38L WWTR1 FOXO4 ITGAL NDRG1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260710%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRF7 MAPK8 IRAK4 TNF TLR7 ICAM1 IL10 TLR8 CCL3L1;CCL3L3;CCL3;CCL18 IRF5 MAPK14 IRAK1 IL6 CHUK RELA IKBKB MAP3K7 IRF1 IKBKG REL TAB1 TRAF3 ELANE MYD88 CCL4L2;CCL4L1;CCL4 CXCL8 GZMH;GZMB-1 VCAM1 IL1A NFKB1 NFKB2 RELB NFKBIA LCN2 TAB2 TRAF6 TLR4 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260710%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis NOS1 PRMT1 NOS2 CARM1 DDAH1 NOS3 PRMT8 PRMT7 PRMT3 DDAH2 PRMT5 PRMT2 PRMT6 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders ADK MAT1A BHMT AHCY CTH MAT2B MTR-1 CDO1 GNMT CSAD CBS;CBSL PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260710%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCD1 PIK3CD PIK3CB PLCE1 PIP5K1B PIP5K1A PIK3CA PI4K2A IPMK PLCB3 MTMR2 INPP4B PLCB4 INPP5E PLCB1 PLCB2 FIG4 PI4KA PIP4P2 PIP4P1 PIP4K2A PIP4K2B INPP4A INPP5D INPP5K PIP4K2C PI4K2B PLCG1 SACM1L TPTE;TPTE2 MTMR1 PI4KB MTMR8 OCRL MTMR6 MTM1 PLCG2 PIK3C2G PIP5K1C PIK3C2A PIKFYVE PIK3CG PLCD3 PTEN PIK3C2B PLCD4 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260710%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGFR HRAS GRM1 CASP7 CASP3 RPS6KA5 HTT ELK1 CREB1 NTRK2 BDNF MAP2K2;MAP2K1 RAF1 MAPK1 EGF MAPK3 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260710%WP325%HOMO SAPIENS Triacylglyceride synthesis DGAT2 MOGAT3 GPAM DGAT1 LPL GK2 LIPF AGPAT4 LIPE LIPC GK PNPLA2 PLPP3 GNPAT PLPP2 GPD1 AGPS MOGAT2 MOGAT1 AGPAT1 AGPAT3 AGPAT5-1 AGPAT2 PLPP1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260710%WP550%HOMO SAPIENS Biogenic amine synthesis GAD1 GAD2 PNMT CHAT TPH1 ASMT HDC COMT AANAT TH PAH ACHE DDC MAOA DBH INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260710%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions FOXO1-1 IL2RG SOCS3 CX3CR1 TNF STAT5A STAT5B IL2RA IL2RB IL10RB CCR6 IGF1R FOXP3 IL18 TNFRSF1B EBI3 LGALS3 LGALS1 IL33 CCL20 CD28 CNP CXCL2;CXCL3;CXCL1-1 NKX2-2 CXCL12 MOG PLP1 RAC1 CD68 CD44 STAT3 FAM20C SIRPA;SIRPB1;SIRPG NLRP3 TGFBR1-1 MYD88 IL12RB1 AREG JAK1 IL12RB2 HEXB CASP1 TGFBR2 TGFBR3 GALC ROS1 PDGFRA FOXO4 SPP1 OSM IFNG STAT1 HTR7 NKX6-1 EGFR IL10RA TGM2 CCL1 CD4 SSTR2 MAPK14 IL2 IL6 OLIG2 PDGFA ITGB3 FOXO3 SMAD2;SMAD3 MMP9 PTK2 IL1B NFKB1 NFKB2 IKZF2 TGFB2 CCN3 STAT4 NKX6-2 VEGFA MCAM TMEM119 SEMA3F KLRG1 CCR8 ITGAV NOS2 IL10 ITGA2 CD86 TGFB1 CD80 IL4 CTLA4 IL12A GSDMD IGF1 CD274 P2RY12 CDC42 PDCD1 IL1RAP CSPG4 SOX9 MBP CD47 AIF1 JAK3 OLIG1 TYK2 TLR4 APOD NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260710%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NOD1 NLRP7;NLRP2 NLRC4 RAC1 MEFV NLRP4 AAMP CARD9 CARD6 ACAP1 NLRP10 SUGT1 RIPK2 ERBIN PRDM1 NOD2 NLRP3 CHUK AIM2 NAIP RELA IKBKB DUOX2 IKBKG IL18 CASP9 NLRP12 CASP7 CASP8 NLRP1 CASP1 CASP5;CASP4 IL1B NDUFA13 XIAP HSP90AA1 COPS6 PYCARD NFKBIA LUPUS PATHOGENESIS%WIKIPATHWAYS_20260710%WP5559%HOMO SAPIENS Lupus pathogenesis LOC102723996;ICOSLG ICOS IL17A BCR TLR7 TLR9 CD86 CD80 CD40LG IL6 CD40 CD28 TNFSF13B CD274 TNFRSF13C PDCD1 TLR4 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260710%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners LATS2 NF1 SKI HDAC3 ING2 SATB2 STK3 PRMT5 MECP2 TEAD1 TEAD2 SKIL TEAD3 TEAD4 SIN3A HDAC1 MERTK LATS1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260710%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2A LPAR6 P2RY2 P2RY1 ADORA3 LTB4R ADORA2B ADORA1 LPAR4 P2RY6 P2RY4 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260710%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease LMNA DMPK HSPB2 HP1BP3 HSPB3 NOTCH3 H2AZ2;H2AZ1 DES LBR MYOG MYOD1 MEF2C CBX5 LMNB1 ACTA1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260710%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome PRMT1 RAB5A IFITM3;IFITM2;IFITM1 VAV2 KDR NFATC2IP IL4 TUFM ATXN2L SPNS1 C3-1 RABEP2 ATP2A1 RABGEF1 MPL SH2B1 RAB4A CD82 CR2 LAT TRAF1 CD19 NFATC2 INSR CD81 GRB2 JAK2 TRAF2 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260710%WP4917%HOMO SAPIENS Proximal tubule transport SLC1A1 SLC6A19 SLC7A7 AQP1 SLC6A18 SLC5A8 SLC12A4 SLC5A2 ATP6V0E2;ATP6V0E1 SLC6A20 SLC5A5 ATP6V1F SLC16A10 SLC22A2 SLC34A1 SLC26A6 ATP6V1C1 SLC9A3 SLC5A1-1 ATP6V1E1 ABCC4 SLC2A1 ABCC2 SLC22A7 ABCG2 ATP1B1 SLC4A2 SLC22A11 SLC3A2 ATP6V1G1 ATP6V0B SLC13A3 ATP6V0C ATP6V1B1 SLC36A2 ATP6V1A SLC22A6 CLTRN SLC7A9 SLC47A1 SLC20A2 SLC3A1 ATP1A1 ABCB1 ATP6V1H ATP6V0A4 ATP6V1D SLC22A8 FXYD2;FXYD6-FXYD2 SLC2A2 SLC7A8 CA2 CA4 ATP6V0D2 SLC4A4 GPCRS OTHER%WIKIPATHWAYS_20260710%WP117%HOMO SAPIENS GPCRs other LGR6 CHRM3 C5AR2 ADGRL2 HTR7 ADGRL3 GPR83 DRD3 DRD4 SSTR2 OR2F1-2 GRPR F2R PROKR2 CCR5 EDNRA ALG6 OR1F1 RXFP1 PTGFR OR10A5 OR2A7;LOC107987545;OR2A4 CXCR1 CELSR1 CXCR2 CNR1 NTSR1 GPR183 ADORA2A GPR17 GPR18 S1PR1 SMO OR2B6;OR2B2-1 GRM1 HTR2A OR2H1-1 CELSR2 HTR1F CCKBR FSHR GPR143 ADRA1D OR1E1;OR1E2 OR3A1 ADRB2 P2RY13 P2RY11 OR2M4 GPR61 GPR62 OR7E24-1 CELSR3 RXFP3 GPR176 CXCR3 GPR132 ADGRE3 GPR135 ADGRV1 CCR2 OR8G1;OR8G5 GNRHR TAAR5 OR1J2 TAAR2 OR1N1 ACKR1 GPR162 LTB4R2 ADGRF5 ADORA3 VN1R1 OR6C3 GPR88 GPR84 MCHR2 GHRHR ADGRG1 HRH4 CHRM2 OR6C2;OR6C68 UTS2R OR5AC2-2 GPR55 ADGRD1 OR2A5 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260710%WP12%HOMO SAPIENS Osteoclast signaling MAPK8 ACP5 IFNB1-4 TNFRSF11A GPR68 PDGFB CTSK ATP6V1G1 TNFSF11 TRPV5 SPP1 IFNAR1 SLC9A1 ITGB3 AIMP2 TNFRSF11B PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260710%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins VPS16 ATG4A VPS39 VPS33A VAMP8 NBR1 TMEM59 MAP1LC3B2;MAP1LC3B-1 PKM VPS41 PRKAA2 RPS6 ATG7 ATG5 CALCOCO2 ULK1 APOB SQSTM1 RHEB AKT1 GABARAPL2 ATG16L1 OPTN-1 MTOR ATG9A EIF4B RPS6KB1 PPP1R9A TAX1BP1 MLST8 RAB7A VPS18 RB1CC1 LAMP2 LARP1-1 ATG3 LAMTOR1 AKT1S1 ATG2B ATG13 DEPTOR RPTOR VPS11 ATG12-1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP5393%HOMO SAPIENS Androgen biosynthesis SRD5A1 SULT2A1-4 HSD17B3 HSD17B4 HSD17B1 HSD17B2 POR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SRD5A2 CYP11B1;CYP11B2 HSD11B1 HSD11B2 AKR1D1 CYP17A1 HSD3B1;HSD3B2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260710%WP47%HOMO SAPIENS Hedgehog signaling PTCH1 STK36 SAP18 GLI1 ARNTL DHH IHH GLI3 GRK2 GLI2 PTCH2 KIF7 SIN3A SHH SMO SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260710%WP4814%HOMO SAPIENS Somatic sex determination FGF9 FOXL2 NR5A1 RSPO1 SRY SOX9 DMRT1 GATA4 WT1 ZFPM2 PTGDS WNT4 DHH SOX8 CTNNB1 AMH TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260710%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRF7 IRAK3 IKBKE IRAK4 TIRAP TNF IFNB1-4 IRAK1 IL6 CHUK IKBKB MAP3K7 IKBKG TAB1 TRAF3 RIPK1 MYD88 CXCL8 TBK1 INPP5D TRAM1 NFKB1 TICAM1 IRF3 NFKBIA TAB2 TRAF6 TLR4 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260710%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups OAT ASL PYCR1 GATM GAMT NAGS ARG1 CKM CKB ODC1 PYCR3 SRM ALDH18A1 ARG2 SARDH GLUD1;GLUD2 ASS1 CPS1 ACY1;ABHD14A-ACY1 SMS OTC GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260710%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells LDHA SLC16A1 SLC2A1 PDP1 PFKP PDK1 HK1 PKM DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260710%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 FMO3 CHDH SLC44A1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260710%WP2806%HOMO SAPIENS Complement system C5AR2 CD59 IBSP LRP2 APOA1 MASP2 ICAM1 MASP1 CFD VSIG4 ADIPOQ PLG CD93 CFHR1;CFHR2 FCER2 C6 CSNK1A1 C8A APCS C7 FKBP2 C9 CD55 F11 LAMC1 F10 ITGA2B C1QBP C3-1 C1S PTX3 C5AR1 C2 C5 ITGB3 C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 FPR1 TXN ADM SELE SELL CD40 LAMB1 DCN ICAM2 ARRB2 MBL2-1 ITGA2 GNA15 SELPLG F13A1 PLAUR FCGR3A;FCGR3B TLR2 CALR-1 CLEC4M;CD209-2 WAS GNAI3 PRKACA-1 LAMA5 RPS19 SELP VTN GNAI2 CR1L;CR1 ALB CPN1 CFH-3 ELANE F12 PRKCA CD19 SERPING1 FGB FGA C4BPA FCN2;FCN1 KLKB1 FGG CFB CFI CFP THBS1 PRNP SPP1 CRP PROS1 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260710%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection NPPB NOS1 NPPA NOS2 CNGB1 TNF CAMK2D CAMK2B GUCY1A2 GUCY1A1 CREB1 BAD PDE3A PPID GRIN2A CNGA2 TSPO CNGA3 BCL2 CNGA4 RELA CNGB3 GRIN2C GRIN2B GRIN1 GRIN2D DLG4 NPR1 CASP9 CYCS-1 NEFL PDE2A AKAP9-1 CAMK2G NOS3 CAMK2A ACTN2 IL1B CNGA1 NFKB1 XIAP CALM1 GUCY1B1 NFKBIA IFNG PRKG2 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260710%WP2006%HOMO SAPIENS miR targeted genes in squamous cell NRP1 HES1 GALNT1 TMEM59 MOV10 ARF4-1 SDCBP PISD PKM TMEM43 CPNE8 PICALM VEZT SRSF9 LAMC1 SRPRB-1 PWP1 AP2A1 DHX57 ARFIP1 HOXA7 CIAO2A MRPS33 TXNRD1 FNDC3B FNDC3A GFPT1 DHX40 HMOX1 AP3D1 MAP3K8 P4HA2 TMED10 UBE2J1 MRPL20 VCAM1 SPCS3 COMMD9 ELOVL5 ATP6V1C1 TRAM1 GYS1 MAGT1 MRC2 FGF2 CUL4B CSDE1 PXDN PTMA RTN4 TMED2-1 PPP1R7 MPZL1 ARCN1 ANXA2 TBCA LAMTOR5 ACAA2 PODXL RHEB AXL POGLUT3 GNAI2 E2F3 NEDD4 RARS1 PNP-1 SPTLC1 PDLIM7 RAB34 RAI14 CBFB ADIPOR2 TGFBR2 SIGMAR1 SLC38A2 THBS1 SLC4A10 CHMP2A POLR2C ATRX MTPN HSD17B12 DNAJB1 ADAR SH3BP4 SLC12A2 GALNT7 POM121;POM121C SLC38A1 ATP6V0E2;ATP6V0E1 FMNL2 GOLGA7-1 ATP6V1F BET1 FBXW11 ANP32B SYNE2 PEDS1-UBE2V1;PEDS1 POLD2 MET AKAP8 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HNRNPM TMED7 CTDSP1 SMAD1 PRPF40A TPM3 SEC23A TPM1 IDH1 GAS2L1 ANPEP TUBA1A YWHAQ ATP2A2 PDCD4 NCL-1 NF2 SH3BGRL3 AMINO ACID METABOLISM%WIKIPATHWAYS_20260710%WP3925%HOMO SAPIENS Amino acid metabolism MMUT GPT2 HADH ARG1 GOT2-1 ACAA1-1 TPH1 ARG2 PKM GLUD1;GLUD2 ACSS1 G6PC2 HNMT HMGCS2 ALDH7A1 DLD EHHADH-1 MARS2 DDC PPM1L MAOA IARS1 MPST DBH ACADM VARS1 OGDH AOC3 PDHX SUCLG1 LDHA FAH BCAT1 CS TDO2 LARS2 PCK1 CAD PDHA1 MDH1 P4HA2 MDH2 ALDH18A1 ASNS ASS1 TH PC CPS1 CTH OTC HIBADH EPRS1 FH AUH OAT PYCR1 HIBCH SRM HMGCL MCCC1 TPO ACLY TAT DLST IDH1 SDHA SMS WARS1 GCLM SDS ALDH1A1 ADH5 ACO2 RARS1 PNMT FTCD ODC1 HDC GOT1-1 BHMT FARSB ADH4 ADH1C;ADH1B;ADH1A PDK4 GLS GLUL GSS GSR CBS;CBSL HAL RANKL RANK SIGNALING%WIKIPATHWAYS_20260710%WP2018%HOMO SAPIENS RANKL RANK signaling CBL MAPK8 MAP2K7 PAPSS2 MAP2K6 JUN MAPK14 SPI1 MAP3K7 FHL2 SQSTM1 AKT2 TNFRSF11B AKT1 TRAF1 TRAF3 LYN PIK3R2 PLCG1 PTK2 NFKB1 TNFSF11 NFKB2 RELB TAB2 RAC1 MAPK9 TNFRSF11A MITF PIK3R1 CHUK SRC RELA NFATC1 MAP2K2;MAP2K1 IKBKB MAPK1 SYK IKBKG CDC42 MAPK3 MTOR TAB1 TRAF2 FOS NFKBIA GAB2 STAT1 TRAF6 TRAF5 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260710%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta MBTPS2 ITPR1 P4HB LRP5 PLOD2 TNFRSF11A FZD1 SERPINH1 LRP6 TNFRSF11B PLOD1 FKBP10 ADAMTS2 MIA3 TMEM38B BMP1 COLGALT1 LOX SP7 IFITM5 CRTAP CREB3L1 P3H2 P4HA1 WNT1 P3H1 P4HA2 PPIB TNFSF11 MBTPS1 SERPINF1 COL1A1 COL1A2 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260710%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome AXIN1 NKX6-1 HSPD1 PDX1 TERT GATA4 TBX5 SLBP ERI1 CLDN23-1 TLR2 TNKS SLC35G4;SLC35G5;SLC35G3;SLC35G6 CGAS FDFT1 RP1L1 BLK SGPL1 RAF1 MAPK1 CTSD SOX7 CTSB MAPK3 BMP1 NUMA1 S100A10 MSRA CSTA PINX1 HEPACAM2 C8orf74 DEFB135 MFHAS1 PPP1R3B FAM167A MCRS1 TERF1-1 XKR6 MTMR8 MTMR9 MTMR6 SLC2A4 MTMR7 MEPE CTNNB1 NEIL2 TLR4 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway FOXO1-1 GSTA3;GSTA5;GSTA1;GSTA2 RXRA SMC1A NCOA6 PTPA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALAS1 NCOA1 EHHADH-1 SP1 ABCB1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP2C9;CYP2C19 UGT1A1;UGT1A6 PPARGC1A NCOA2 DNAJC7 SULT2A1-4 CYP2B6 ABCC3 HSP90AA1 CYP2A13;CYP2A6;CYP2A7-1 ABCC2 NR1I3 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260710%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNQ1 KCNJ2 HDAC4 HCN4 SRF KCNE1;KCNE1B HCN2 PTBP2 IGF1 GJA1 HAND2 ERG LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2874%HOMO SAPIENS Liver X receptor pathway CYP2B6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCD FASN RXRA CYP7A1 SREBF1 ABCG8 ABCG5 NR1H3 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260710%WP2877%HOMO SAPIENS Vitamin D receptor pathway CEBPA FOXO1-1 CLEC16A IL1RL1 CCND1 CDX2 MXD1 ADRA1B CCNE1 IRF4 IRF8 IGFBP5 S100A8 NOX1 RASGRP1 HIF1A ALOX5 GADD45A HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 SULT2A1-4 G0S2 BTLA IL25 NFATC2 CYP27B1 CYP2B6 CASP5;CASP4 EPHB4 LGALS9C;LGALS9;LGALS9B LPGAT1 TRPV5 GXYLT2 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 KRT71 ALPG;ALPP;ALPI-1 SLC34A2 SLC2A4 CDC34 NINJ1 S100A4 STAM COL13A1 KLK6 CRACR2A CYP2S1 CRACR2B SLC37A2 CYP1A1 CST6 KRTAP8-1 TRPV6 PNOC SPRR1A;SPRR1B CLPTM1L IGSF9B CD200 ORM2;ORM1 MED9 CASP14 S100A2 ADGRE5 SULT1C2 DACT2 HSD17B2 CA9 ABCD1 TIMP3 SERPINB1 SATB1 S100A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SEMA3B PRDM1 ADRB2 ASAP2 S100A9 CLMN CREG2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 LRRC25 S100G PTH KRT13 MYO9B CCNC-1 CYP2D6;LOC107987479;LOC107987478-1 DEFB132 PPARD KLF4 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 CD9 ABCB1 CYP2C9;CYP2C19 PRKCQ NRIP1 KRT16;KRT14 CDKAL1 CDKN2D KL CDKN1A COLEC11 JUNB FGF23 ATP2C2 CYP7A1 SPP1 CDKN2B CDKN2C DUSP10 TIMP2 HNF1A EFNA5 CLDN2 ID4 CDKN2A LRRC8A CYP24A1 MYC TRAK1 TNFRSF11B STS SALL4 SFRP1 DND1 TNFSF4 TNFSF11 CD40 SOSTDC1 BCL6 ITGAM TGFB2 CDKN1B CDK2 TNFAIP3 ADAMTS5 TREM1 PTHLH RXRA LRP5 TGFB1 IRF5 CTLA4 IL12A CAMP PTGER4 G6PD TPM1 BMP6 KNG1 CD14 BDKRB1 SLC8A1 VDR ATP2B1 STEAP4 ID1 IGFBP3 DEFB4A;DEFB4B IGFBP1 THBD CBS;CBSL DNER REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260710%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC3 BUB3 CDC20 BUB1 MAD2L1 STAG1 SMC1A CENPE PTTG1;PTTG2 MAD1L1 APC BUB1B ESPL1 RAD21 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260710%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders TK2 RRM2-1 RRM1 TYMS CKB RRM2B DPYS TYMP NT5C UPB1 NT5C3A DPYD DHODH UMPS PUS1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260710%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC46A1 ALDH1L1 MTHFD2L FOLR1 SLC19A1 MTR-1 TYMS FTCD ATIC MTHFR QDPR DHFR2;DHFR MTHFD1 MTHFD2 GART SHMT2 SHMT1 ALDH1L2 ST20-MTHFS;MTHFS OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260710%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies CEBPA LMNA HES1 TMPO HES5 TARBP2 LEMD3 CREBBP CEBPD DICER1 CSNK1A1 MYOD1 MAOA TNFRSF11B TCF7 AGO2 FNTA SMAD2;SMAD3 ICMT WNT10B CTSK MSTN TGFB2 RUNX2 GSK3B AXIN1 TLE1 NOTCH1 LEF1 SREBF1 TGFB1 TCF7L2 HMGA2 TCF7L1 WNT7B APC CEBPB BMP2 MAOB RB1 CDKN1A EMD KAT2B JUNB NAP1L1 ZMPSTE24 E2F1 ACTB-1 SPP1 CTNNB1 HDAC1 CDK4 PPARG IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260710%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NUBP1 NUBP2 GLRX5 NFS1 LYRM4 FDX1 HSCB FDXR FXN NFU1 HSPA9 ISCU CIAO2B NARF ABCB7 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260710%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases BECN1 BUB3 MYL2 PGK1 PRPS1 H3-3A STAT3 PKM KHK SNAP23 AKT1S1 PDK1 PAK2 AXON GUIDANCE%WIKIPATHWAYS_20260710%WP5289%HOMO SAPIENS Axon guidance NRP1 TRPC1 CFL1 RYK-1 SLIT2 FES EFNA1 ARHGEF12 RAF1 SHH WNT5A MYL12B CDK5 BMPR1B GDF7 BMPR2 WNT4 ROBO2 MET PLXNA1 CXCL12 ILK GSK3B RAC1 DCC HRAS SEMA3A PDPK1 RASA1 PARD3 DPYSL2 EPHB1 ITGB1 ENAH NGEF ROCK1 SRC L1CAM CXCR4 MAPK1 NTN4 CDC42 GNAI1 NTN3 ABL1 PTCH1 FYN SEMA5B ROBO3 RGMA DPYSL5 NCK1 SEMA6C BOC PRKCA UNC5D SEMA7A EPHA2 EFNB1 FZD3 ABLIM3 SLIT1 LRIG2 SLIT3 LRRC4C SRGAP2 NTNG2 RHOD PRKCZ PARD6A RRAS ROBO1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260710%WP5050%HOMO SAPIENS TCA cycle in senescence TP53 BRAF FH PDP2 ME2 PDHA1 MDH1 PDK1 ME1 GOT1-1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADS HADH CPT2 SLC25A20 PECR ACADVL CPT1A SCP2 ACSL1 ECI1 EHHADH-1 ACSL4 ACSL3 ACSF2 HADHA ACADL ACADM KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260710%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KLKB1 KNG1 CPN1 BDKRB2 BDKRB1 F12 SERPING1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260710%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP4B1 CYP1A2 RARA NR1H4 RARB ABCB11 CYP8B1 PPARA CYP24A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PPARD NR1H3 ABCB1 NR1I2 CYP2C9;CYP2C19 ABCD3 CYP2E1 ABCG1 RARG ABCA1 VDR CYP27B1 CYP2B6 ABCD2 ABCC3 CYP7A1 ABCG5 ABCC2 ABCB4 CYP26A1 NR1I3 PPARG HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260710%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease MAPK8 SMAD2;SMAD3 FLNA FBN1 SERPINE1 TGFBR1-1 SHC1-1 AGTR1 MAPK14 CCN2 SMAD4 ANGPT2 TGFBR2 TGFBR3 ENG FBN2 POSTN LTBP1 FBN3 LTBP2 MAPK1 RUNX2 NR2C2 MAPK3 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260710%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP2 TIMP4 MMP1 MMP14 TNF MMP21 MMP20 MMP24 MMP27 MMP28 MMP11 TIMP3 MMP16 MMP15 MMP17 MMP19 MMP8 MMP25 TIMP1 MMP7 MMP23B MMP12 MMP3 MMP13 MMP9 TCF20 MMP2 BSG MMP10 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260710%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface SMAD7 NCAM1 PGF SMAD2;SMAD3 TGFBR1-1 CD14 ITGA1 TGFB1 CXCL8 CD4 ANGPT1 IL2RA FCGR3A;FCGR3B SMAD4 ANGPT2 KLRC4-KLRK1;KLRK1 TGFBR2 SMURF2 VEGFC ITGAE FOXP3 CD9 IFNG CXCL10 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260710%WP259%HOMO SAPIENS Nifedipine activity CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCNA BDKRB2 MAP2K2;MAP2K1 PTK2B SOD1 MAPK1 KDR CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260710%WP530%HOMO SAPIENS Cytokines and inflammatory response IL11 TNF IL10 IFNB1-4 IL15 TGFB1 CD4 IL4 IL5 IL2 IL6 CSF3 PDGFA CSF2 IL3 IL7 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DRA CSF1 IL1A IL12B IL1B IL13 CXCL2;CXCL3;CXCL1-1 IFNG LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260710%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance TP53 HIF1A WNT6 BCL2L1 ABCB1 CDKN1A ENDOMETRIAL CANCER%WIKIPATHWAYS_20260710%WP4155%HOMO SAPIENS Endometrial cancer TP53 FGFR2 EGFR CTNNA1 BAK1 CTNNA3 CCND1 CTNNA2 CDH1 FGFR1 ARAF BAX MYC FGF1 RAF1 AKT2 AKT3 TCF7 AKT1 FOXO3 GADD45A CASP9 PIK3R2 DDB2 APC2 BRAF GRB2 ILK FGF2 GSK3B PTEN PIK3CD AXIN1 GADD45B PIK3CB HRAS SOS2 GADD45G POLK PDPK1 LEF1 ERBB2 PIK3CA TCF7L2 TCF7L1 PIK3R3 BAD SOS1 PIK3R1 APC NRAS MAP2K2;MAP2K1 MAPK1 MAPK3 KRAS CDKN1A ELK1 FGFR3 CTNNB1 FOS EGF AXIN2 NOTCH SIGNALING%WIKIPATHWAYS_20260710%WP61%HOMO SAPIENS Notch signaling MAML2 HES1 HES5 EP300 JAG2 DLL1 DLL3 FBXW7 AKT1 SKP1 PIK3R2 NOTCH3 NOTCH4 DLL4 NFKB1 CUL1 ITCH JAK2 GSK3B TLE1 NCOR2 NOTCH1 NCOR1 STAT3 ADAM17 SNW1 PIK3R1 SRC SAP30 JAG1 MTOR NUMBL MAML1 DTX1 NOTCH2 APH1A APH1B NUMB MAML3 FHL1 HEY2 RBPJ LCK CIR1 PSENEN HDAC2 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN SPEN HDAC1 PSEN2 HES6 RING1 PSEN1 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260710%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control GDAP1L1 PMPCA UBXN6 OXA1L PINK1 PPA2 YME1L1 HSPD1 MICU1 CLPP SPG7 MFF TIMM50 LONP1 MSTO1 MCL1 PYCR3 DNAJC19 TIMM8A AGK TIMMDC1 TMEM126A-1 GFER AIFM1 USP9X COQ5 COQ3 NPLOC4 SFXN4 STAT2 RTN4IP1 C1QBP MIPEP TXN2 TRAK1 SACS TXNRD2 HTRA2 UFD1 PLEK MICOS13 PMPCB DNM1L PYCR1 SLC25A46 ATAD3A;ATAD3B AFG3L2 PITRM1 OPA1 PYCR2 VCP-1 HSPA9 XPNPEP3 PRKN MFN1 MFN2 MARCHF5-1 UBXN1 CLPB OPA3 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260710%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB SUCLG2 PDHX LDHA SUCLG1 FH PCK2 LDHA;LDHC GPT DLST DHTKD1 SUCLA2 MPC1 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260710%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum PCNA SLX4IP GPS1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CETN2 XPA XPC POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 RAD23A RPA1 GTF2H1 GTF2H3 RAD23B POLD3 GTF2H4 DDB2 POLD4 USP7 RBX1 CUL4A DDB1 POLD1 POLD2 POLE4 CDK7 ERCC3 ERCC4 ERCC1 POLE2 RPA3 LIG3 POLE3 ERCC2 ERCC8 ERCC6 MNAT1 CUL4B BRCA1 XRCC1 XAB2 POLK H3-3A PARP1 SLX4 HMGN1 POLH RAD18 CHD1L H4C1 H4C6 H4-16 UVSSA MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260710%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 IRF7 ACE2 PHB CTSV;CTSL PHB2 IKBKE NDUFB9 TMPRSS2 TLR7 ECSIT TLR3 ACAD9 CGAS IFIH1 BCS1L NDUFAF1 TOMM70 MAVS NOX1 TRAF3 ACE TBK1 AGTR1 REN AGTR2 NLRX1 DDX58 NFKB1 TICAM1 NFKB2 IRF3 TRAF6 STING1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260710%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO1 FMO2 FMO3 FMO4 FMO5 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260710%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC14 H2BC21 H2BC5 H4C1 H2BC1 H4C6 H4-16 TERF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AZ2;H2AZ1 H2BC15;H2BC3;H2BC11;H2BC12 TERF2IP H2AC20 TERF1-1 H2AJ H2AB2;H2AB3;H2AB1 ACD TINF2 POT1 TPP1 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260710%WP3944%HOMO SAPIENS Serotonin and anxiety related events PPP3CA CRH NLGN1 CRHR1 HTR2A PLEK ARC PRKCB FOS GRIN2D HTR1A PLCD4 SERINE METABOLISM%WIKIPATHWAYS_20260710%WP4688%HOMO SAPIENS Serine metabolism PHGDH DHFR2;DHFR SRR PSAT1 PSPH TYMS SHMT2 SHMT1 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260710%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RARA RARB RXRA RXRG RARG RXRB BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260710%WP272%HOMO SAPIENS Blood clotting cascade F13B KLK1 F2 SERPINF2 F5 F3 F7 SERPINE1 F8 F9 F12 SERPINB2 PLG FGB FGA KLKB1 PLAT FGG F11 F10 PLAU VWF ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260710%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 CASP1 IL1B NFKB1 NLRP3 TRAF3 RELA PYCARD UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260710%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin IL2RG CCL8 TNF ITGA4 NCR1-1 STAT5A IL10 STAT5B MADCAM1 MCL1 IL15 CCL3L1;CCL3L3;CCL3;CCL18 GATA2 ANGPT1 IL4 IL2RB MAPK11 IL6 BCL2 PIBF1 MRC1 CCL5 GAB3 CXCR4 MAPK3 IL3 CXCL10 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CXCR3 NR3C1 CCL4L2;CCL4L1;CCL4 CCL13;CCL2 JAK1 CXCL8 VCAM1 PGR ESR2 CD69 ANGPT2 CXCL11 SELL MAP2K4 CXCL12 JAK3 VEGFA CX3CL1 IFNG RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260710%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS ITPR1 CAMK2D CAMK2B ATF4 CMA1 CTSG CREB1 ITPR2 CYP11B1;CYP11B2 GNAQ ITPR3 CALM3;CALM1 PLCB2 CALM2 CAMK1D CAMK1G ATF6B CREB3 CREB3L3 CREB3L4 CREB3L1 CAMK4 CREB3L2 ACE CAMK2G CAMK1 CREB5 ATF2 AGT CYP21A2 AGTR1 CAMK2A REN AGTR2 CYP11A1 ATF1 CALM1 HSD3B1;HSD3B2 STAR CALML6 CALML3 CALML4 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260710%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COL9A1 COL9A3 COL9A2 MATN1 COMP MATN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP453%HOMO SAPIENS Inflammatory response pathway IL2RG FN1 CD86 CD80 IL2RA IL4 IL2RB IL5 IL2 LAMC1 COL3A1 LAMA5 IL5RA LAMC2 VTN LAMB2 TNFRSF1B THBS3 CD40LG CD40 LAMB1 CD28 ZAP70 THBS1 LCK IL4R TNFRSF1A COL1A1 COL1A2 IFNG VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260710%WP4271%HOMO SAPIENS Vitamin B12 disorders MMAA MMACHC MMUT MMADHC CUBN CD320 MTRR MMAB TCN1 MTR-1 CBLIF TCN2 AMN PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260710%WP4147%HOMO SAPIENS PTF1A related regulatory pathway KAT2B NKX6-1 NOTCH1 PTF1A RBPJL PDX1 HES1 PROX1 RBPJ CTNNB1 FGF10 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260710%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA OXSM MCAT MECR HSD17B12 AUTOPHAGY%WIKIPATHWAYS_20260710%WP4923%HOMO SAPIENS Autophagy PRKAG1 BECN1 PRKAG2 PIK3C3 PRKAG3 UVRAG PRKAB2 AMBRA1 PRKAB1 PRKAA1 ATG101 MAP1LC3B2;MAP1LC3B-1 PRKAA2 ATG7 ATG5 ULK1 PIK3R4 ATG16L1 MTOR ATG9A WIPI2 ATG14 MLST8 RB1CC1 ATG3 AKT1S1 ATG13 DEPTOR RPTOR ATG12-1 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260710%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1A2 ESR1 SLCO4C1 HSD3B1;HSD3B2 SLCO4A1 HSD17B3 HSD17B1 HSD17B2 SLCO2B1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ESR2 CYP19A1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260710%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 APAF1 MAPK10 CASP9 HSPA1A;HSPA1B CYCS-1 CASP7 CASP8 CASP3 RIPK1 BID FADD MAP3K1 FASLG CASP6 AIFM1 NFKB1 FAS TNFRSF1A CASP2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260710%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming SOX2 EGR1 POU5F1;POU5F1B TRIM71 MYC KLF4 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP69%HOMO SAPIENS T cell receptor signaling CBL MAPK8 PTK2B PTPN11 JUN CD4 MAPK14 CD3G CD3E CD247 MAP3K7 RAF1 REL AKT1 CBLB PSTPIP1 MAP3K8 PIK3R2 FYB1 NFATC2 PLCG1 NFKB1 ITK CD28 GRB2 MAP4K1 CRKL HRAS VAV3 SH2B3 ITPR1 PDPK1 CD8A MAPK9 RIPK2 CARD11 CREB1 MAP3K14 SOS1 PIK3R1 CRK CHUK PRKCD RELA NFATC1 WAS MAP2K2;MAP2K1 IKBKB PAK1 CD3D MAPK1 GRAP2 VAV1 IKBKG BCL10 CDC42 MAPK3 LCP2 MALT1 PRKCQ ICOS LAT FYN SHC1-1 NCK1 ATF2 SKAP1 ZAP70 LCK DBNL FOS NFKBIA GAB2 TRAF6 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260710%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes CPOX TERT ARF4-1 SDCBP CCND1 CDIPT AP2A1 UAP1 GNPNAT1 GFPT1 HMOX1 AP3D1 FADS2 TM6SF1 FADS1 SPCS3 VCAM1 ELOVL5 FXR2 AGO3;AGO1 MYCN PTPRJ PTMA SMC1A AURKB PTPA HDAC4 TBCA TCL1A NCOA3 PNP-1 RB1 CDKN1A KCNQ1 TGFBR2 PRKCI CDK6 POLR2C EGFR CSNK1D MCL1 THEM4 CDKN2A ADAR MAPK14 MAPK12 MYLIP BCL2 LAMC2 PLAG1 CHD1 TNFSF9 ANP32B MET TRIP13 PPP5C G6PD IDH1 GAS2L1 CLDN1 ANPEP CEBPB TUBA1A YWHAQ NOTCH2 NCL-1 NT5C3A CTNNB1 RHOB NRP1 PISD SLC25A22 CAP1 PHC2 SLC25A13 HIPK3 IGF2R TMEM43 ELMOD2 CSRP1 SRSF10 PICALM SRSF9 CDKN1C TXN2 TXNRD1 CYP1B1 PPP3R1 GPD2 ANAPC1 TDG USP1 GSTM4 CXCL12 ABCG2 PLK1 PTPRF RHOG IGF2BP1 E2F3 MYO1E IPO4 CHAF1A PLXND1 CYP51A1 RDH10 EHMT1 ASH2L POM121;POM121C SERPINE2 SLC38A1 C1orf56 GOLGA7-1 SAC3D1 ATP6V1F ADPGK PTRH1 UNC93B1 SHOC2 POLD2 HARS1 ARFIP2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HNRNPM PPP3CA UBE2S CAPG ITGA2 DHX15 PRPF40A TPM4 PTBP2 TPM3 MAPK7 TPM1 KIT SLC25A1 NF2 BACE1 STRN MOV10 PKM PDE3A CPNE8 VEZT LAMC1 SRPRB-1 PWP1 C1QBP CHORDC1 RAVER2 COL4A2 CDK5RAP1 ANKFY1 CIAO2A SEC62 CDK5RAP3 TMEM41B-1 MBNL1 IFRD1 FNDC3B FNDC3A SCAMP1 PGM1 DHX40 MAT2A CARHSP1 METTL7A-1 WDR82 FAR1 MAP3K8 P4HA2 HACD3 UBE2J1 MRPL20 COMMD9 GRPEL2 ATP6V1C1 ATP6V0A1 SNX6 NCEH1 TRAM1 GYS1 GFM1 PSAT1 MAGT1 MRC2 PANX1 SFXN1 COIL TMED3 GNL3L-1 FGF2 CTSC MRPS24 AP3B1 GAK SLC7A6 CDCP1 CSDE1 FRG1 PXDN PAFAH1B2 BRPF3-1 AMIGO2 DCAF7 NAPG PGRMC1 ATAD3A;ATAD3B RTN4 PPP1R7 MPZL1 SPRYD4 TTC9C ARCN1 WDR11 TPPP3 NFIA SNX15 NUCB1 LAMTOR3 BDNF LAMTOR5 IQGAP3 ACAA2 TUSC2 LTN1 ARID4B LCLAT1 ABHD10 RHEB POGLUT3 KPNA3 RARS1 KRAS STX7 UBE4A CDKAL1 RAB30 DMTF1 SYPL1 RAB34 WDFY1 MATR3 GEMIN7 PPIB RAI14 CBFB SLC1A4 ADIPOR2 CORO1C SLC9A3R2 SIGMAR1 RAB6A SLC38A2 CD164 SLC4A10 CHMP2A SNAP23 DOCK7 TNFAIP2 LMNB2 TMEM109 ACP2 SCYL1 HSDL1 ATRX SSNA1 RCN2 RBMS1 MTPN LUZP1 EIF4E NUFIP2 NXN UHRF1 HSD17B12 DNAJB1 CAND1 TP53INP1 SH3BP4 LRRC8A ZNF622 KCNN4 SLC12A2 PDLIM5 SLC25A24 IRS1 GALNT7 SLC12A4 MYO10 SLC4A7 ATP6V0E2;ATP6V0E1 FMNL2 SLC25A32 NAA15 BET1 ARHGDIA WNT5A DDX5 GNA13 SYNE2 AKAP8 BCL6 CDKN1B PPP2R5C CNOT9 DOCK5 BACH1 SNAP29 MTRR ATP2A2 TYMS DNMT3B DNMT3A CACNA2D1 CCN1 MTHFD2 SYNE1 TMEM59 GALNT1 RAB23 ZEB1 NELFCD DHX57 ARFIP1 MRPS33 ARL10 MARS2 TPM2 PURA TMED10 MYB RAD23B POLE4 CUL4B ARID1A VPS39 TRPV6 TMED2-1 ANXA2 ABHD11 CALCOCO2 PKN2 AXL GNAI2 EHMT2 NEDD4 ATG9A SPTLC1 PDLIM7 PRIM1 POLA2 RAB5C RAB27B E2F1 MTX1 LPL EZH2 ATAT1 NT5E RRP8 RFT1 HOXA5 GTPBP3 FBXW11 OTULINL CEP72 VTI1B FERMT2 HOXD8 VAMP3 TAF9B PEDS1-UBE2V1;PEDS1 TRMT1 LY6K MSI2 MPDU1 NPR3-1 ATG3 BRI3BP RCOR1 MEOX2 YIF1B GEMIN2 ARID2 UTP15 RBM19 BCKDHB CLOCK TMED7 NOTCH1 PTBP1 PPIF SMAD1 SEC23A NARS1 SUCLG2 SEC24A PDCD4 GPAM ABCF2-H2BE1;ABCF2 SH3BGRL3 BLADDER CANCER%WIKIPATHWAYS_20260710%WP2828%HOMO SAPIENS Bladder cancer TP53 RASSF1 HBEGF EGFR MMP1 HRAS RPS6KA5 CCND1 ERBB2 CDH1 CDKN2A DAPK2 DAPK3 PIK3R1 NRAS DAPK1-1 SRC ARAF MAP2K2;MAP2K1 MYC RAF1 MAPK1 MDM2-2 KRAS PIK3R2 RB1 CXCL8 CDKN1A TYMP BRAF MMP9 THBS1 E2F1 FGFR3 MMP2 VEGFA EGF CDK4 UPK3A ERBB SIGNALING%WIKIPATHWAYS_20260710%WP673%HOMO SAPIENS ErbB signaling TP53 FOXO1-1 HBEGF CBL EGFR MAPK8 BCL2L11 MAP2K7 SHC4 STAT5A STAT5B CCND1 JUN ABL2 BUB1B-PAK6;PAK6 ARAF MYC NRG2 RAF1 AKT2 AKT3 MDM2-2 AKT1 CBLB EREG BTC SHC3 PIK3R2 NRG1 SHC2 CAMK2A BRAF PTK2 ERBB4 GRB2 CRKL CDKN1B GSK3B NRG3 NRG4 PIK3CD RPS6KB2 PIK3CB HRAS SOS2 PDPK1 CAMK2D MAPK9 ERBB2 PRKCB PIK3CA CAMK2B GAB1 PAK5 PIK3R3 BAD SOS1 PIK3R1 CRK NRAS EIF4EBP1 SRC MAP2K2;MAP2K1 PAK1 MAPK1 PAK3 PAK2 MAPK3 PAK4 MAPK10 KRAS MTOR NCK2 TGFA ABL1 RPS6KB1 SHC1-1 NCK1 AREG CAMK2G PRKCA CDKN1A ELK1 PRKCG MAP2K4 ERBB3 PLCG2 EGF ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP138%HOMO SAPIENS Androgen receptor signaling FOXO1-1 EGFR FLNA CREBBP RAN KDM1A CCND1 KAT5 JUN EP300 PARK7 AR UBE2I BUB1B-PAK6;PAK6 PIAS3 CCNE1 FHL2 TGFB1I1 PRDX1 MDM2-2 AKT1 SUMO1 SMAD2;SMAD3 CARM1 PIK3R2 RLN2;RLN1 SMAD4 CAV1 SMARCE1 PTK2 ETV5 SIN3A RUNX2 GSK3B NR2C2 PTEN RNF14 RAC1 STUB1 RAD9A EFCAB6 UBE3A BRCA1 PIAS4 NCOR2 PIAS2 NCOR1 ZNF318 PIAS1 FKBP4 RNF6 RNF4 PSMC3IP BAG1 PATZ1 DSTN NCOA4 STAT3 SIRT1 CREB1 TLE5 PIK3R1 ROCK1 ROCK2 CALR-1 NCOA1 SRC RELA ZMIZ1 SP1 CDC42 NCOA2 NCOA3 TGIF1-1 RB1 KAT2B DAXX RHOA RACK1 LIMK2 SMIM40 CTNNB1 NR0B2 HDAC1 RHOB HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260710%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SNAI2 ELF3 SUZ12 KDM1A TGFB1 SIX1 CDH1 KLF8 FOXC2 ZEB1 SIRT1 EZH2 SUV39H1 PRRX1 ZEB2 GRHL2 TCF4 HDAC2 ELF5 GSC2 HDAC1 SNAI1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260710%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FOXQ1 JUN FZD1 PROM1 DKK3 TCF4 IGFBP5 WNT5A BMPR1A SFRP1 MSX1 CCN2 SMAD4 SOX2 GLI2 ZBTB16 WIF1 DKK4 NFKB1 SOSTDC1 KITLG FOSB DKK1 S100A4 PERP KLK6 KRTAP8-1 NOTCH1 GATA3 LEF1 CD200 BCL11B FOXE1 CASP14 HR ADAM17 HOXC12 PHLDA1 SPINK6 SPINK5 KRTAP3-2;KRTAP3-3-1 ADAMTS20 SMAD1 DSG1 DSG4 DLX3 KLK5 NFATC1 KLK4 IGF1 KLK7 GAS1 CUX1 BMP6 LRIG1 GSDMA BMP4 EGR2 KLK13 KLK14 FOXN1 KRT19 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 CD34 LGR5 TP63 SOX9 GTPBP4 MSX2 GJB6 ELANE NR3C1 NOTCH2 FST GPRC5D RUNX3 LHX2 KRT15 RBPJ CTNNB1 FOS IFNG DSC2 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260710%WP2878%HOMO SAPIENS PPAR alpha pathway RXRA CDK1 APOA2 FABP1 APOA1 CYP8B1 ACAA1-1 CPT2 CCND1 KLK15 APOA5 PPARA PLTP SLC27A1 CPT1A SCP2 CYP7A1 APOC3 MYC EHHADH-1 NR1H3 CDK4 ACADM NAD METABOLISM%WIKIPATHWAYS_20260710%WP3644%HOMO SAPIENS NAD metabolism NRK CD38 SIRT3 PARP1 SIRT1 NAMPT NADK NMNAT3 SIRT6 NMNAT1 NMNAT2 NT5E SIRT4 SIRT5 SIRT2 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260710%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS TP53 GRIA1 PPP3CA RAC1 PPP3CB NOS1 SLC1A2 CAT TNF RAB5A BID MAP2K6 MAPK14 BAD BCL2 NEFH BAX MAP2K2;MAP2K1 BCL2L1 GPX1 CST3 PPP3CC APAF1 CASP9 DERL1 PRPH ALS2 CASP3 NEFL SOD1 NEFM CASP1 TOMM40 DAXX MAP3K5 SMIM40 TNFRSF1A CCS ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260710%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance AKT1 MAPK8 TRAF1 PDX1 SMPD3 TNF PRKAG3 RPS6KB1 EIF2AK2 CPT1B CD36 INS;INS-IGF2 INSR PIK3R1 IRS1 ACSL1 PRKCZ IRS2 SLC2A4 ERN1 TNFRSF1A PPP2CB;PPP2CA MAFA RETINOL METABOLISM%WIKIPATHWAYS_20260710%WP5188%HOMO SAPIENS Retinol metabolism SDR16C5 ALDH1A1 RDH12 AWAT2 CYP1A1 LRAT BCO1 DHRS4 PNPLA4 AOX1 RDH13 RPE65 CYP2W1 DHRS9 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP2A13;CYP2A6;CYP2A7-1 ERYTHROPOIESIS%WIKIPATHWAYS_20260710%WP5607%HOMO SAPIENS Erythropoiesis EPOR CD34 HBG2;HBG1 KIT HBZ HBD;HBB TF CD79A GATA2 GATA1 HBA2;HBA1 TFRC FASLG GDF11 KITLG FAS EPO PTPRC IL3 IL3RA NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260710%WP4220%HOMO SAPIENS Neurotransmitter disorders COMT TH SLC6A3 SLC18A2 PNMT TPH2 TPH1 DDC MAOA DBH TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260710%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders FAH TAT HGD HPD GSTZ1 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260710%WP2113%HOMO SAPIENS Type III interferon signaling IL10RB STAT2 IFNLR1 IFNL2;IFNL3;IFNL1 JAK1 STAT1 IRF9 TYK2 FOXA2 PATHWAY%WIKIPATHWAYS_20260710%WP5066%HOMO SAPIENS FOXA2 pathway PPARGC1B FOXO1-1 ACACA GSTA3;GSTA5;GSTA1;GSTA2 MTTP GSTM1;GSTM2-1 SREBF1 SLC27A5 INS;INS-IGF2 IRS1 FASN FOXA1 ABCC3 ABCC4 IRS2 APOB FOXA2 ABCC2 GSTA3;GSTA1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260710%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ICMT ZMPSTE24 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260710%WP334%HOMO SAPIENS GPCRs class B secretin like ADGRL2 ADGRL3 ADCYAP1R1 CALCRL CRHR1 CRHR2 ADGRE5 GIPR GCGR GLP2R SCTR PTH2R ADGRE1 PTH1R ADGRG2 CALCR ADGRL4 GHRHR ADGRL1 VIPR1 GLP1R VIPR2 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260710%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ACAA1-1 PPARA ACOX3 GGT5 ACOX1 EHHADH-1 PPARD TRPA1 TRPV1 ALOX5 ALOX15 HPGD LTB4R ALOX12 FPR2 LTC4S LTA4H ACOX2 CYSLTR1 LTB4R2 CYSLTR2 PTGR1-1 ALOX15B DPEP1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260710%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias CTSV;CTSL STAT5B HMGCS1-1 FGFR1 PLAT PTH1R CDKN1C FGF18 PLAU MGP SOX6 IGF1R ADAMTS1 AKT1 BMPR1A COL10A1 GLI3 MMP13 MMP9 DDR2 THRA ACAN CHST11 CALM1 TGFB2 MEF2C VEGFA FGF2 RUNX2 ADAMTS4 ADAMTS5 NKX3-2 PTHLH FRZB SCIN TGFB1 IHH TIMP3 KIF3A IFT88 HDAC4 SERPINH1 PTH IGF1 PRKACA-1 BMP6 CAB39 SOX9 PTCH1 SOX5 IGF2 RUNX3 ALPL ENPP1 BMP7 COL2A1 SLC38A2 FGFR3 GHR SPP1 STAT1 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260710%WP4918%HOMO SAPIENS Cellular proteostasis PFDN4-1 VBP1 PFDN1 PFDN2 PFDN5 PFDN6 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260710%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma PRCC EGLN1 FH CREBBP VHL TGFB1 CUL2 EP300 ARNT BIRC7 SETD2 ELOC-1 HIF1A TGFA DVL2 TFEB EGLN2 CDKN1A EGLN3 TFE3 RBX1 PDGFB EPAS1 CTSK SLC2A1 ELOB TGFB2 TGFB3 CADM2 VEGFA COL21A1 SFPQ-1 DIAPH1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260710%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27B1 CYP24A1 CYP2R1 CYP27A1 RXRA DHCR7 PTH VDR GC RXRB CAFFEINE IN NEURONS%WIKIPATHWAYS_20260710%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260710%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis SPI1 IRAK1 NFKB2 RELA APOE TRAF6 TLR4 TLR2 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260710%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCD1 MAPK8 TNF IFI44L RXRG JUN MAPK14 MAPK12 CYP24A1 IFNAR2 MAPK13 MAPK11 IFNGR1 NOD2 IL6 STAT2 IFNGR2 SP3 CCL13;CCL2 CXCL8 CAMK2A CYP27B1 CAV1 NFKB1 CD40 NFKB2 RELB MED1 HRAS RXRA PLCE1 CAMK2D MAPK9 TLR8 PRKCB CAMK2B TLR2 PLCB3 PLCB4 CAMP NRAS PLCB1 PLCB2 PRKCD MAPK7 IKBKB MAPK1 SP1 PRKCE MAPK3 ISG15 PRKCQ ETS1 KRAS JAK1 CAMK2G VDR PRKCA CD40LG PRKCG PRKCH PRKCZ PLCG2 DEFB4A;DEFB4B TNFRSF1A IFNG STAT1 IFI27L2 TYK2 TLR4 RSAD2 RXRB IL5 SIGNALING%WIKIPATHWAYS_20260710%WP127%HOMO SAPIENS IL5 signaling RPS6KB2 STAT5A STAT5B PTPN11 JUN STAT3 RPS6 IL2 PIK3R1 SOS1 MAP2K2;MAP2K1 RAF1 MAPK1 SYK IL5RA MAPK3 AKT1 FOXO3 KRAS RPS6KB1 LYN SHC1-1 GSK3A PIK3R2 JAK1 CSF2RB ELK1 GRB2 JAK2 SPRED1 BTK PIK3CG STAT1 GSK3B MAPT RPS6KA1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260710%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HEXIM1 PPP3CA SUPT4H1-1 PPP3CB NFATC3 HDAC3 NELFB CREBBP HDAC9 HDAC7 EP300 NFATC4 CDK9 NELFCD NELFA NELFE HDAC4 RELA NFATC1 SP1 PPP3CC PPP3R1 CCNT1 HDAC5 NFATC2 HDAC8 NFKB1 HDAC2 SUPT5H NFKBIA HDAC1}