S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a3 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Gcdh Echs1 Acat1 Acat2 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Inpp5d Itpka Inpp5f Synj1 Inpp5a Itpkc Itpkb Ipmk Bpnt2 Impa2 Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Acsm5 Acsbg2 Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Acat1 Acat2 Fdps Idi1 Hmgcs1 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Adh6 Adh4 Maob Comt Aldh3a2 Tomt Aldh2 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Mthfd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Ip6k2 Plcb2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Itpk1 Cdipt Pik3cg Pik3cb Pik3cd Pip4p2 Pip4p1 Inpp5d Pi4k2b Itpka Plcz1 Pik3c2b Synj1 Plce1 Inpp5a Pik3c2a Itpkc Pik3c2g Itpkb Fig4 Ipmk Mtmr3 Ppip5k1 Pip5k1c Pten Pip5k1b Inpp5k Synj2 Inppl1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Prodh1 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss1 Acss3 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Dhodh Cad Umps GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Sod3 Sod2 Sod1 Cat MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufab1 Ndufc1 Ndufc2 Sdhd Sdhc Sdhb Sdha Ndufa11 Cox6a1 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Mt-co3 Mt-co2 Ndufs8 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa5 Ndufa7 Ndufa6 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cox5b Mt-co1 Cyc1 Mt-nd5 Mt-nd4 Ndufb2 Mt-nd6 Mt-nd1 Uqcrc2 Ndufb3 Mt-nd3 Uqcrc1 Mt-nd2 Mt-nd4l Ndufb8 Ndufb7 Ndufb9 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcr11 Ndufa10l1 Mt-cyb DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dolk Dhrsx Dhdds Nus1 Srd5a3 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Gart Paics Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 Adsl Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Ak7 Pfas Ak8 Atic Ppat Guk1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk1 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Coq2 Coq3 Ubiad1 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm2 Impdh2 Impdh1 Rrm2b Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Dguok Nme3 Dck Nme2 Nme1 Nme7 Nme6 Guk1 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 Ugt2b34l1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Gls2 Gls Asns VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Vkorc1 Nqo1 Ggcx Vkorc1l1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Ada Pnp GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gsta6 Gsta3 Gsta1 Gsta2 Anpep Gstm7 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Gstp1 Gstt2 Mgst2 Mgst1 Gstt1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart Mthfd1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Alox5 Lta4h Ptgs2 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Selenoi Pcyt2 Cept1 Etnk2 Etnk1 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Gpx4 Alox12 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal1 Hyal5 Hyal4 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp5mc1 Atp6v1b2 Vps9d1 Atp6v0d1 Atp5mc3 Atp5mc2 Atp5mf Atp5me Atp6v0e1 Atp5mg Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h Atp6v0b Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp6v1c1 Atp5pf Atpaf2 Atp5po Atp6v0c Atp6v1a Mt-atp6 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Shmt2 Shmt1 Mthfd1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Gart Pfas Ppat PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Hmgcs1 Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Lbr PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcs2 Acat1 Hmgcl Bdh2 Bdh1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Akr1a1 Cryl1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Cdipt Plcb4 Plcb3 Pi4k2b Plcz1 Plcb2 Plce1 Plcb1 Pi4k2a Plcg1 Plcg2 Pip5k1c Pip5k1b Pip4k2b Pip4k2c ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Acss1 Aldh3a2 Acss3 Aldh2 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Echs1 Acadsb Acat1 Acat2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads2 Elovl7 Fads1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 St3gal6 St3gal4 St3gal5 St3gal2 B3galt1 B3gnt5 B3gnt2 Fut2 A4galt B4galt1 Fut1 B4galt2 B4galt3 B4galt4 B3galnt1 B4galt6 St6gal1 B4galnt1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis St8sia2 St8sia3 Ugcg St3gal6 St3gal4 B3gnt5 B3gnt2 B4galt1 B4galt2 B4galt3 B4galt4 B4galt6 St6gal1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Aldh7a1 Chdh ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chkb Selenoi Gnpat Pcyt1b Pcyt1a Far2 Far1 Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk2 Etnk1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Kmo Ido2 Acmsd Ido1 Dhtkd1 Kyat1 Tdo2 Aadat Haao Kynu Got2 Aldh8a1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Cyp2a3 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 Hsd17b7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Elovl7 Fads1 Acsm4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt4 Ugcg St8sia1 B4galt6 St6gal1 B4galnt1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt5 B3galt1 Fut2 Abo2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Cyp2e1 Akr1b10 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Ctps1 Dhodh Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Ipmk Itpk1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Ptgis Tbxas1 Cbr1 Hpgds Hpgd Akr1c18 Ptgs1 Ptgs2 Ptges Ptgr2 Ptgds Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Inpp4b Pip4p2 Pip4p1 Inpp5d Inpp5f Synj1 Sacm1l Mtmr3 Pten Mtmr14 Inpp5k Synj2 Inpp4a Inppl1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Gpx4 Alox12 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ephx3 Dpep2 Cyp4f18 Cyp2j4 Cyp4f4 Cyp2d4 Alox15b Lta4h Ptgs2 Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s Ptgis Tbxas1 Hpgds Hpgd Ptgs1 Ptges Ptgr2 Ptgds Ptgr1 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Pten Inpp5k Synj2 Inppl1 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ip6k1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio3 Dio1 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Alox5 Ptgs2 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Acat1 Bdh2 Bdh1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd Dhtkd1 Aldh8a1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx4 Gpx1 Gpx3 Gpx7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nmnat1 Nmnat2 Nampt HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Cds2 Agpat2 Agpat1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Fa2h Hacl1 Aldh3a2 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Pc Pgk1 Pgam2 Tpi1l2 Pgk2 Fbp1 Pck1 Fbp2 Bpgm Gpi Mdh1 Mdh2 Eno1 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc3 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc3 Maob Aldh3a2 Aldh2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Tecr Hsd17b12 Elovl1 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Acsm5 Acsbg2 Fads2 Elovl5 Hsd17b12 Acsl1 Acsm3 Elovl7 Acsbg1 Fads1 Acsm4 Slc27a2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Gclm Oplah Gclc Gss Cndp2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ctps1 Ctps2 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Hk3 Pygb Pygl Gck Pgm1 Hk2 Pgm2 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Bckdhb Bckdha Dbt Abat Bcat1 Dld Hibch Bcat2 Echs1 Hibadh Aldh6a1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ntan1 Ate1 Naa20 Ntaq1 Apeh Metap2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Alox5 Ptgs2 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk3 Gck Pgm1 Hk2 Pgm2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 Tsen54 Rtraf Fam98b Tsen2 C9h2orf49 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tyms Dck Tk2 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Pycr1 Aldh18a1 Pycr2 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gstp1 Gsta3 Gsta1 Gsta2 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5e Nt5c3a Impdh2 Impdh1 Ada Pnp Gda Xdh Nt5c1a L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Cbs Cth Ahcy Mat2a Mat1a L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Srm Enoph1 Adi1 Kyat1 Mri1 Mat2a Apip Mat1a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Inpp5f Synj1 Inpp5a Bpnt2 Impa2 Impa1 Inpp5k Inpp1 Synj2 Inppl1 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Gstm4 Dpep2 Alox5 Lta4h Dpep1 Ltc4s PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp4 Rbp1 Xdh GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclm Gclc Gss DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Maob Comt Aldh3a2 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis St3gal5 Ugt8 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Sat2 Sat1 Aldh1b1 Aldh3b1 Aldh3a1 Maob Aldh3a2 Aldh2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Bckdhb Bckdha Mccc1 Dbt Auh Bcat1 Ivd Dld Mccc2 Bcat2 Hmgcll1 Hmgcl GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Aspg Asrgl1 Aga Got1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Adh6 Sult1a1 Ugt2b34l1 Aldh3a2 Aldh2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adsl Ak3 Ak2 Ak4 Adss2 Ak7 Ak8 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat1 Plaat5 Plaat3 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kmo Ido2 Ido1 Tdo2 Haao Kynu UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcb4 Plcb3 Plaat3 Plaat1 Plaat5 Plcb2 Plcb1 Pla2g2e Pla2g2d Pla2g2a Pla2g4e Pla2g4d Plcg1 Pld4 Plcg2 Pla2g4a Pld6 Pld1 Pld3 Plb1 Pld2 Pla2g12a Pnpla8 Pla2g5 Pla2g3 Pla2g6 Plch2 Pla2g1b Plcd1 Oc90 Plcd4 Pla2g10 Plcd3 Plcz1 Plce1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Gclm Gclc Got1 Gss COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcdc Coasy Pank3 Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Tpi1l2 Aldob Aldoc Tkfc Khk Aldoa PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1l1 Prps1 Prps2 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Cda Tyms Nme3 Dck Nme2 Nme1 Cmpk2 Cmpk1 Tk2 Nme7 Nme6 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chkb Chpt1 Pcyt1b Pcyt1a Chka Cept1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Adh6 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Aanat Tph2 Ddc Tph1 Asmt Tdo2 Haao Kynu Aldh8a1 Kmo Akr1a1 Ido2 Nmnat1 Cyp2a3 Acmsd Ido1 Nmnat2 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 Sult1a1 Maob Ugt2b34l1 Aldh2 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acsbg2 Hsd17b10 Acox1 Acox2 Scp2 Hsd17b4 Ehhadh Acaa1b Echs1 Hadh Acsbg1 Slc27a2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Akr1a1 Ddc Maob Aldh3a2 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Tars1 Hars1 Pars2 Dars2 Yars2 Yars1 Dars1 Lars2 Gars1 Qars1 Lars1 Farsa Farsb PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Rrm2 Rrm2b Nme3 Ada Nme2 Nme1 Pnp Nme7 Nme6 Adsl Adk Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Hprt1 Ak7 Aprt Ak8 Guk1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Dctd Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Ctps1 Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 Ctps2 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Aldh7a1 Shmt2 Chdh Dmgdh Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Fh Idh3a Dlst Idh3b Dld Cs Idh3g Suclg1 Suclg2 Ogdh Aco2 Mdh1 Mdh2 Sdhd Sdhc Sdhb Sdha N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Hadhb Acaa2 Acsbg2 Hsd17b10 Eci1 Scp2 Echs1 Hadh Acsbg1 Hadha Slc27a2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Adh1 Sord LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis St3gal5 B3galt5 B3galt1 B3gnt5 Ugcg Fut2 B4galt6 St6gal1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Kmo Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Tdo2 Haao Kynu Aldh8a1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Sdr16c5 Rbp4 Rbp1 Aldh1a2 Aldh1a1 Aldh1a3 Rdh16 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide Fut9 Chst1 St8sia2 B4galt1 Fut1 Abo2 B4galt2 B4galt3 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Upp1 Dpys Upp2 Dpyd THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio3 Dio1 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Fads1 Acsm4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pgk1 Pgam2 Tpi1l2 Pgk2 Pklr Pfkl Pkm Pfkm Pfkp Bpgm Hk3 Gpi Gck Eno1 Hk2 Gapdhs Aldob Aldoc Eno3 Eno2 Aldoa HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B3galt5 Gcnt3 B3gnt2 Fut2 B4galt1 B4galt2 B4galt4 Lalba St6gal1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh2 Impdh1 Pnp Xdh HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galt5 St3gal2 Ugcg Fut2 A4galt Fut1 B3galnt1 B4galt6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk3 Gck Hk2 Treh LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Cyp2c11 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rdh11 Rdh12 Rdh10 Rpe65 Rbp2 Rbp3 Dhrs9 Lrat Rlbp1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Hsd17b3 Srd5a1 Hsd3b1 Srd5a2 Akr1c18 Cyp17a1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Impdh2 Impdh1 Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rdh11 Rdh12 Rdh10 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ephx3 Gpx4 Alox12 Alox5 Cyp2d4 Ptgs2 Alox15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3r2 Pik3r3 Pik3r4 Pi4kb Cdipt Pik3cg Pik3cb Pik3cd Pikfyve Pi4k2b Pik3c3 Pik3c2b Pik3c2a Pik3c2g Sacm1l Fig4 Pi4k2a Pip5k1c Pip5k1b Pik3r5 Pik3r6 Pip4k2b Pik3r1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gale Hk3 Gnpnat1 Uap1 Gnpda2 Gpi Pgm3 Gck Hk2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Acot2 Acsbg2 Acot3 Hsd17b12 Elovl6 Acsl1 Elovl7 Acot7 Acsbg1 Slc27a2 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Hoga1 Prodh2 Got2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f4 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Sgpp1 Acsbg2 Acer1 Acer2 Asah2 Acsl1 Asah1 Acsbg1 Sphk2 Sphk1 Ptgr1 Slc27a2 Sgpp2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Ada Pgm2 Pnp PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Tymp Cda Upp1 Upp2 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4k2a Plch2 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 Pip4p2 Pip4p1 Plcz1 Plcb2 Plce1 Plcb1 Mtmr3 Plcg1 Plcg2 Mtmr14 Pip4k2c ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c1 Akr1c2 Srd5a1 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Shmt2 Shmt1 Mthfd2l Aldh1l2 Mthfd1 Mthfd2 Mthfs Mthfr Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Ada Hprt1 Pnp REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Sod3 Sod2 Sod1 Gpx1 Gpx3 Gpx6 Gpx5 Gpx7 Cat Gpx8 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5e Nt5c3a Ada Pnp Xdh Nt5c1a ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Akr1b10 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Tmlhe Bbox1 Aldh9a1 Shmt1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ippk Ipmk Itpk1 Inpp5k Synj2 Inppl1 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Gpx4 Alox12 Alox5 Alox15b Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Cel Daglb Pnliprp2 Pnpla2 Pnlip Lipc CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Gne Nanp Nans Cmas CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Qprt Nadsyn1 Nmnat2 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) St8sia2 Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 St6gal2 St6gal1 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Acss1 Cyp2e1 Aldh3a2 Acss3 Aldh2 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Acss1 Aldh3a2 Acss3 Aldh2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Pccb LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1l3 Glb1 Lct NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Cyp4x1 Fmo3 Cyp2a3 Cyp2u1 Fmo2 Cyp2s1 Fmo5 Fmo4 Ugt1a5 Ugt2b34l1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Gale Galt Pgm1 Galm Pgm2 Galk1 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Hk3 Gnpnat1 Uap1 Gpi Pgm3 Gck Hk2 Gfpt1 Gfpt2 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Paics Adsl Atic L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aldh7a1 Dhtkd1 Aadat Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Sephs1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Hacl1 Phyh Aldh3a2 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Lcmt2 Tyw3 Tyw1 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Plaat1 Plaat5 Napepld Pla2g1b Enpp2 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Echs1 Acadsb Acat1 Acat2 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Kmo Ido2 Nmnat1 Qprt Nadsyn1 Ido1 Nmnat2 Tdo2 Haao Kynu LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsbg2 Acsl3 Acsl1 Acsbg1 Slc27a2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Plcb1 Dagla Ddhd1 Daglb ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Hemk2 Slc20a2 Slc20a1 Trmt112 Aqp9 Slc34a2 Pnp Aqp7 Slc2a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp2b2 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Pgm2 Ugp2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Alox5 Lta4h Ptgs2 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Pmm1 Gpi Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Shmt2 Dmgdh Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Tst Suox HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas2 Hmbs Uros Fech Cpox Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Pccb L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Bckdha Sdsl Dbt Dld Sds GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Hprt1 Pnp CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Asl Ass1 Nos3 Nos2 Nos1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Cbs Cth Bckdhb Bckdha Dbt Suox Dld Mat2a Pccb Mat1a Ahcy Cdo1 Bhmt Bhmt2 Mtr Got1 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Pmvk Hmgcr Mvd Hmgcs2 Acat1 Acat2 Idi1 Hmgcs1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Gpat4 Plpp4 Lpcat3 Mogat1 Gpat2 Gpat3 Plpp2 Lpcat4 Plpp3 Plpp1 Agpat5 Dgat2 Gpam Plppr4 Abhd5 Dgat1 Mboat2 Plppr2 Agpat3 Plppr3 Lclat1 Agpat4 Agpat2 Agpat1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw3 Tyw1 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Csad Fmo1 Cdo1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Mdh1 Mdh2 Got1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Il4 Cabin1 Pou2f1 Ifng Cd40lg Akap5 Faslg Csf2 Junb Nfatc3 Nfatc2 Ptgs2 Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Tfe3 Dcp1a Rbl1 Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Dlx1 Nr3c1 Myod1 Max Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Sap18 Cited1 Sp3 Runx3 Runx1 Runx2 Kat2a Cbfb Vdr Rbbp7 Esr1 Hspa8 Crebbp Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 Tcf3 Cdkn1a E2f5 Smad7 Jun Fos Atf2 Il10 Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Foxo3 Foxo1 Creb1 Col1a2 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il23a Il17a Nfkbia Rela Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il18 Il12b Tnf Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Jak2 Cxcl3 Nos2 Il24 Il17f SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ran Pias1 Pias2 Hdac1 Ranbp2 Xpo1 Hdac4 Ube2i Mdm2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Rela Pik3r1 Mapk8 Mapk1 Ilk Itgav Mapk3 Jun Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Fos Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Rock2 Chuk Map3k14 Nfkb1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Mapk1 Mapk3 Fkbp1a Smad4 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Smad7 Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Src Pxn Irs2 Grb10 Pdlim7 Gdnf Ptpn11 Gfra1 Pik3r1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Dok6 Grb2 Mapk8 Prkca Mapk1 Sos1 Crk Hras Mapk3 Jun Rhoa Bcar1 Rac1 Prkaca Ret Grb7 Shank3 Creb1 Shc1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Mapk1 Col11a1 Mapk3 Col11a2 Fgf19 Cask Ccl5 Bsg Prkaca Hpse Ppib Col2a1 Sdcbp Col3a1 Col1a1 Mmp9 Mmp7 Col4a3 Col5a2 Col6a2 Mmp1 Tgfb1 Col4a1 Hgf Col5a1 Col4a5 Fgf23 Fgfr3 Fgfr4 Lama5 Sdc1 Met Col1a2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Grb2 Prkca Sos1 Hras Rasa2 Rabgef1 Camk2b Nf1 Rasal1 Dab2ip Kras Prkcz Plce1 Lgals1 Lgals3 Rasgrf2 Nras Prkcb AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkc Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Irs1 Irs2 Cebpb Grb2 Il5 Sp1 Col1a1 Socs3 Jak2 Stat5a Pik3r1 Spi1 Stat6 Alox15 Socs5 Ets1 Jak3 Aicda Jak1 Fcer2 Il13ra1 Il13ra2 Arg1 Bcl2l1 Mybl1 Irf4 Oprm1 Tff3 Lta Inpp5d Ptpn6 Thy1 Cbl Ccl17 Il4 Mtor Selp Ccl11 Cd40lg Rps6kb1 Pigr Egr2 Parp14 Mapk14 Il4r Il2rg Stat5b Bcl6 Il10 Fes Hmga1 Retnlg Akt1 Col1a2 Shc1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Rela Ptpn11 Pik3r1 Jak3 Jak1 Grb2 Sos1 Bcl2l1 Il2ra Rac1 Il2 Mtor Rps6kb1 Il2rg Smpd1 Eif3a Hsp90aa1 Sgms1 Rps6 Gab2 Myc Tert Lck Bcl2 Akt1 Prkcz E2f1 Nfkb1 Ugcg Foxo3 Shc1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Frs3 Irs1 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ntf4 Ntf3 Ptpn11 Pdgfrb Ifngr1 Vegfa Gab1 Pdgfb Frs2 Il6r Arhgap35 Nos3 Egf Igf1 Ntrk2 Grb2 Map2k2 Sos1 Ntrk1 Map2k1 Ntrk3 Hras Igf1r Il6 Kras Jak2 Nras Stat1 Pik3r1 Jak3 Jak1 Rhoa Il2ra Prkaca Il2 Ifng Il2rg Gab2 Lck Bdnf Afdn Angpt1 Lmo4 Ngf Shc1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Stat3 Myod1 Ar Ncoa1 Neurog3 Bglap Arnt Ptf1a Runx2 Ghr Camk2d Hif1a Hey2 Maml1 Maml2 Parp1 Crebbp Hes1 Twist1 Ascl1 Rb1 Hes6 Tle1 Gaa Kdm1a Rbbp8 Tcf3 Yy1 Notch1 Gata6 Gata4 Gata1 Cdkn1b Cd4 Ctbp1 Hdac1 E2f1 Jak2 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itgb4 Itga1 Itgb2 Itga2 Itgal Itga10 Itgad Itgb8 Itga7 Itga8 Itgav Itgax Itgb6 Itga3 Itga5 Itgb7 Itga6 Itga9 Itgb1 Itga2b Itgam PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Golga2 Nudc Bora Incenp Kif2a Kif20a Fbxo5 Spc24 Ercc6l Fzr1 Pak1 Ppp1r12a Ect2 Bub1 Tubg1 Cdc14b Cdc20 Ppp2ca Ppp1cb Ccnb1 Rhoa Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Ppp2r1a Wee1 Prc1 Cdk1 Rock2 Btrc Ninl Cdc25c Kiz Tpt1 Aurka Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ube2d3 Xrcc5 Atm Atr Ube2l3 Cdk2 Rbbp8 Ccne1 Cstf1 Bard1 Mre11 Fancl Prkdc Fancc Nbn Tp53 Fancf Fancg Rad51 Rad50 Fancd2 Pcna Ewsr1 Topbp1 Xrcc6 Brca1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Rhoa S1pr5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Src Stat5a Pik3r1 Camk4 Ywhah Ywhag Gab1 Ywhae Epb41l1 Pdpk1 Camk2a Ywhab Trpc3 Grb2 Trpv1 Sfn Ntrk1 Sos1 Egr1 Bad Hras Ccnd1 Plcg1 Gsk3b Prkcd Ywhaz Kras Akt1 Foxo3 Creb1 Nras Shc1 Ngf IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Il18r1 Stat3 Pias2 Mapk8 Jun Il2ra Mapk9 Il13 Fos Cd3g Cd247 Il2 Prf1 Cd3d Cd28 Crebbp Ifng RT1-Da Cd86 Cd80 Tbx21 RT1-Db1 Tgfb1 Etv5 Irf1 Stat4 Il18 Cd4 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Cul3 Klhl13 Vim Kif23 Incenp Aurkc Kif20a Aurkb Bub1 Rhoa Sgo1 Psma3 Aurka Cenpa Klhl9 Ndc80 Stmn1 Kif2c Ppp2r5d Smc4 Smc2 Ncapg Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 Ncapd2 Septin1 Tacc1 Mylk Des Nsun2 Pebp1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pitpna Ntn1 Dock1 Elmo1 Fyn Yes1 Pik3r1 Nck1 Trio Dcc Map1b Dapk1 Pak1 Ptk2 Unc5b Myo10 Camk2a Unc5a Unc5c Map2k2 Mapk1 Map2k1 Mapk3 Rhoa Plcg1 Bcar1 Rac1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 Gnai1 Mapk1 Gnai3 Gna12 Gnaz Gnao1 Mapk3 Gnai2 Plcg1 Rhoa S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Pde3b Mapk1 Pik3r6 Map2k1 Pik3cg C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Myf6 Tab2 Hipk2 Ada Gata3 Myod1 Cebpb Sp1 Hras Ccnd1 Hspa8 Crebbp Hes1 Cdkn1a Gata1 Cdkn1b Cd4 Kras Nras Spi1 Ets1 Ube2i Adora2b Ccna1 Ccnb1 Slc25a3 Birc3 Prtn3 Map3k7 Ets2 Clta Tfec Pim1 Tom1 Cdkn2a Rag2 Atp2b1 Snd1 Maf Ptcra Kit Smarca2 Mcm4 Cd34 Ptgs2 Lef1 Mat2a Trim28 Nlk Cebpa Pias3 Elane Csf1r Gstm2 Yeats4 Wnt1 H2az1 Myc Ppp3ca Kitlg Cbx4 Bcl2 Casp6 Anpep Mad1l1 Ca1 Zfhx3 Cdk6 Col1a2 Lect2 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Rras Src Pxn Ephb1 Ephb2 Ephb3 Tf Efnb1 Efnb2 Pik3r1 Nck1 Efnb3 Rap1a Rap1b Synj1 Dnm1 Pak1 Ptk2 Itsn1 Rock1 Kalrn Efna5 Grb2 Mapk1 Map2k1 Crk Hras Mapk3 Rac1 Kras Grb7 Nras Shc1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Src Pik3r1 Pdpk1 Ikbkb Mapk8 Birc2 Ikbkg Map2k7 Map2k6 Cltc Cflar Birc3 Faim2 Bid Pik3cb Mapk9 Casp8 Rfc1 Casp3 Syk Ripk1 Btk Fas Fadd Map3k1 Ezr Mapk10 Mapk11 Faslg Chuk Mapk14 Smpd1 Akt1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Rela Raf1 Egf Igf1 Mapk8 Map2k2 Mapk1 Map2k1 Bad Mapk3 Birc3 Bid Prkcd Casp8 Ripk1 Fadd Map3k1 Rb1 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Smpd1 Tnfrsf1a Bag4 Cradd Tnf Pdgfa Traf2 Prkra Myc Cycs Map2k4 Sphk2 Bcl2 Akt1 Prkcz Bax Nfkb1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Th Tor1a Src Grk5 Sncaip Slc6a3 Ube2l3 Lyn Prkn Uchl1 Fyn Maob Yes1 Fgr Hck Park7 Snca Bad Fkbp1a Prkcd Syk Ptk2b Ppp2r5d Lck Blk Csnk2a1 Pld1 Plcb2 Klk6 Pld2 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Ikbkb Src Nfkbia Rela Btrc Lck Mapk14 Pik3r1 Nfkb1 Arrb2 Rel Syk RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Srf Ppp1r12a Ccn1 Rock1 Slc9a1 Acta1 Mapk12 Mapk8 Slc9a3 Diaph1 Rdx Map2k6 Cfl1 Jun Msn Rhoa Pten Cit Map2k3 Myl2 Limk1 Fos Limk2 Pkn2 Pkn1 Sh3gl2 Tln1 Pip5k1c Ezr Pip5k1b F2rl2 Rock2 Vcl Scai Atf2 Cdkn1b Map2k4 Prkcz Pld1 Itgb1 Pld2 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Irs1 Egfr Src Pdgfrb Pdgfb Dok1 Egf Grb2 Crk Socs3 Blk Jak2 Itga2b Stat5a Lyn Stat3 Fyn Fgr Pik3r1 Yes1 Hck Rhoa Bcar1 Ins2 Prl Ybx1 Prlr Cdh2 Stat5b Csn2 Csf1 Insr Trpv6 Cav1 Txn Ptpn1 Csf1r Csk Fcgr2a Capn1 Spry2 Fer Lck Lep Nox4 Akt1 Lat Lepr Shc1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Epb41 Lama1 Src Lama3 Itga2 Ephb2 Sdc2 Mapk8 Mapk1 Hras Mapk3 Rhoa Fgf19 Cask Prkcd Prkaca Casp3 Sdcbp Mmp2 Ezr Csf2 Tgfb1 Fgf23 Fgfr3 Fgfr4 Nf1 Bax Fn1 Kng2l1 Cav2 Itgb1 Trappc4 Rack1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Ptpn7 Raf1 Braf Map3k8 Elk1 Prkca Mapk1 Map2k1 Hras Mapk3 Kras Fos Nras Prkcb ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Hrk Ccna2 Serpinb5 Atf3 Kat5 Macroh2a1 Col24a1 Jdp2 Ruvbl2 Jund Csrp2 Gadd45a Sele Prkca Dusp5 Tgfb2 Dusp1 Pdgfra Dusp10 Ccnd1 Dusp8 Hbg1 Ppargc1a Mapk9 Cbfb Esr1 Hes1 Mapk11 Rb1 Cdk4 Socs3 Il6 Nf1 Nos2 Th Il23a Cul3 Mapk8 Mapk1 Arg1 Bcl2l1 Mapk3 Jun Fos Mmp2 Pou2f1 Ifng Plau Ins2 Mapk14 Junb Atf2 Bcl2 Creb1 Brca1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Src Lyn Fyn Yes1 Fgr Hck Rock1 Efna5 Pik3r6 Pik3cg Crk Rhoa Plcg1 Efna1 Efna2 Efna3 Vav3 Arhgef15 Cbl Crkl Ngef Epha1 Epha2 Vav2 Epha3 Epha4 Epha6 Epha7 Cdk5 Epha8 Lck Blk SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Sirt5 Sirt4 Nfkbia Rela Stat3 Ranbp2 Xpo1 Max Hdac4 Ube2i Ran Sap18 Prkaca Rbbp7 Crebbp Btrc Nr2c1 Hdac3 Hdac11 Yy1 Hdac10 Hdac7 Smad7 Mta2 Tnfrsf1a Hdac8 Gata1 Mbd3 Hdac2 Mbd2 Tnf Pparg Chd3 Chd4 Sirt3 Hdac1 Sirt2 Sirt1 Smurf1 Nfkb1 Gatad2a Mxd1 Wdr77 Sirt6 Gatad2b Gata2 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Itga1 Ctnnb1 Klc1 Itga2 Tshr Cdh1 Slc2a4 Adrb2 Scamp2 Rala Acap1 Exoc3 Agtr1 Ctnna1 Exoc5 Exoc6 Vamp3 Nme1 Exoc2 Dnm2 Avpr2 Spag9 Itgav Exoc7 Cltc Bin1 Ctnnd1 Mapk8ip3 Arf6 Pip5k1c Ins2 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Pld1 Itga9 Itgb1 Pld2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ctnnb1 Rala Ywhah Ywhag Xpo1 Ywhae Ran Gadd45a Ywhab Ikbkb Mapk8 Sfn Ccnb1 Plk1 Csnk1a1 Ywhaz Mapk9 Csnk1g3 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Crebbp Ralb Mst1 Mapk10 Sod2 Usp7 Faslg Chuk G6pc1 Rbl2 Cdk2 Cat Csnk1d Sgk1 Bcl6 Csnk1e Cdkn1b Sirt1 Akt1 Foxo4 Foxo3 Foxo1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 Sgpl1 Gna15 Gna14 Abcc1 Gna13 Gnaq Sphk1 S1pr1 S1pr3 S1pr2 Sgpp1 Sphk2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Src Raf1 Slc2a4 Ywhah Ywhag Ywhae Pdpk1 Ywhab Sfn Bad Bcl2l1 Gsk3b Ywhaz Prkaca Mtor Chuk Cdkn1a Cdkn1b Hsp90aa1 Prkdc Rictor Akt3 Akt1 Akt2 Foxo4 Casp9 Foxo3 Kpna1 Foxo1 Mapkap1 Gsk3a Mlst8 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Tiam1 Enah Src Ctnnb1 Nckap1 Klhl20 Ap1m1 Cdh1 Wasf2 Jup Cttn Tjp1 Dlg1 Pik3r1 Abi1 Rap1a Rap1b Ctnna1 Nme1 Crk Ccnd1 Rhoa Ctnnd1 Arf6 Rac1 Pip5k1c Vav2 Akt1 Itgb7 Afdn SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Pik3r1 Stil Dhh Arrb2 Hhip Ihh Lrp2 Gli2 Shh Grk2 Lrpap1 Tgfb2 Smo Ptch1 Boc Pthlh Cdon Akt1 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk1 Plk3 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Wasf2 Abi1 Crk Map2k7 Map2k6 Ncf1 Ncf2 Mapk9 Brk1 Arhgdia Noxa1 Baiap2 Iqgap3 Arpc1b Actr2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Noxo1 Arpc2 Cyba Abi2 Cybb Arpc5 Arpc4 Map3k11 Map2k4 Racgap1 Plcb2 Ctnnb1 Stat5a Cdh1 Stat3 Ctnna1 Pak1 Mapk8 Cfl1 Jun Bcar1 Map2k3 Rac1 Limk1 Pip5k1c Map3k1 Pip5k1b Mapk14 Atf2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Guca1a Rgs9 Lrat Gucy2f Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Cnga3 Arr3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Gnb3 Guca1b Gnb5 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef7 Mcf2l Arhgef6 Spata13 Arhgef9 Fgd1 Git1 Dnmbp Mcf2 Arhgap17 Dock11 Itsn1 Ralbp1 Bcar3 Nme1 Arhgef25 Farp2 Dock6 Arhgap1 Apc Itsn2 Plcg1 Arhgdia Vav3 Ngef Vav2 Racgap1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Elk1 Serpine1 Vegfa Ets1 Sp1 Adora2a Epo Eif3e Arnt Bhlhe40 Efna1 Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Crebbp Pou5f1 Twist1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Sirt1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Src Kat5 Nr3c1 Rel Mdm2 Ar Ncoa2 Ncoa1 Mapk8 Egr1 Map2k6 Jun Gsk3b Pkn1 Pou2f1 Crebbp Mapk14 Smarca2 Nr2c2 Nr2c1 Hoxb13 Carm1 Dnaja1 Zmiz2 Hdac7 Trim24 Cebpa Appbp2 Pde9a Hsp90aa1 Kat7 Nr0b1 Spdef Rxrb Rxra Hdac1 Map2k4 Smarce1 Ehmt2 Sirt1 Smarcc1 Rxrg Senp1 Tmprss2 Foxo1 Rchy1 Rack1 Gata2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Elk1 Pik3r1 Srf Cav1 Jak1 Grb2 Sos1 Crk Itgav Pdgfra Jun Plcg1 Csnk2a1 Fos Cav3 Shc1 Crkl Shf SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncstn Aph1b Egfr Src Ncan Sdc3 Ptn Mc4r Psenen Cttn Pomc Psen1 Fyn Agrp Fgf23 Fgfr3 Fgfr4 Fgf19 Cask SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Atf1 Gdi1 Eif4ebp1 Pla2g4a Mitf Cebpb Rab5a Elk4 Slc9a1 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Eif4e Jun Mapkapk5 Rps6ka5 Hbp1 Ppargc1a Mknk1 Atf6 Esr1 Mef2c Mapk11 Mapk14 Ptgs2 Atf2 Tp53 Nos2 Creb1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Src Pxn Dock1 Git1 Abi1 Ptk2 Crk Bcar1 Spp1 Arf6 Rac1 Ywhaz Prkar1b Prkaca Mdk Jaml Jam2 Cd81 Ptpra Ptk2b Tln1 Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs2 Fn1 Itgb1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Ror2 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Wnt3 Wnt1 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Atf3 Nr3c1 Jund Il5 Sp1 Dusp1 Egr1 Ccnd1 Cbfb Hif1a Esr1 Mmp1 Cdkn1b Il6 Ccl12 Gata2 Th Dmp1 Ctnnb1 Gja1 Edn1 Elf1 Penk Dmtf1 Mt2 Nts Mafg Bag1 Tcf7l2 Cops5 Ets1 Fabp4 Ccn1 Timp1 Agt Acta1 Nppa Fosl1 Jun Pten Fos Bcl2l11 Il2 Il4 Cdkn2a Mmp9 Ifng Plau Cdk1 Maf Csf2 Tgfb1 Junb Nfatc3 Nfatc2 Atf2 Il10 Tp53 Myc Creb1 Col1a2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Sdcbp Stat5a Lyn Ptpn11 Pik3r1 Stat5b Csf2rb Grb2 Il5 Il5ra Cish Jak2 Pim1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Ctnnb1 Pxn Arhgef7 Arhgef6 Xpo1 Ruvbl2 Ppp1r12a Diaph1 Ilkap Ilk Ruvbl1 Rhog Jun Ccnd1 Ppp1r14a Ppp1r14c Gsk3b Ppp1r14b Naca Rac1 Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Parp1 Snai1 Lims2 Zeb1 Actn1 Parvb Zyx Cdc37 Parva Ckap5 Aurka Myl9 Hsp90aa1 Rictor Akt1 Creb1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Ctnnb1 Gja1 Jup Cttn Ptpn11 Pik3r1 Ctnna1 Rock1 Mapk8 Rhoa Plcg1 Ctnnd1 Rac1 Myl2 Gsn Pip5k1c Lrp5 Cdh2 Daglb Camk2g Mapre1 Dctn1 Gap43 Ptpn1 Kif5b Cnr1 Fgfr1 Gria2 Dagla Fer Axin1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Abca1 Fam120b Rara Srebf1 Rps6kb1 Nr4a1 Tgfb1 Ncoa1 Pparg Tnf Rxrb Rxra Med1 Rarg Bcl2 Thrb Thra Rxrg Nr1h4 Nr1h3 Nr1h2 Vdr Ppard Ppara P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Col18a1 Mpg Nrip1 Sra1 Apbb1 Ebag9 Phb2 Pdia2 Anp32a Ap1b1 Cebpb Pou4f1 Lcor Ncoa2 Pou4f2 Ncoa1 Nr0b2 Cd82 Dscam Pgr Axin2 Ccnd1 Tff1 Setsip Ncoa7 Atp5pf C3 Mta1 Hsf2 Xbp1 Esr1 Sod1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Smad4 Uba3 Nedd8 Ctsd Stat5a Hdac4 Jun Chuk Prl Nr0b1 Myc Hdac1 Med1 Pcna Lmo4 Brca1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Rasa1 Pxn Rela Stat5a Elf1 Elk1 Ptpn11 Fyn Pik3r1 Nck1 Agtr1 Ets1 Pak1 Ptk2 Nos3 Grb2 Mapk8 Mapk1 Crk Mapk3 Rac1 Mmp2 Rps6kb1 Tnip2 Mapk14 Grb14 Plg Fgf2 Stat5b Angpt2 Cdkn1a Angpt4 Fes F2 Bmx Elf2 Tnf Itga5 Akt1 Nfkb1 Fn1 Grb7 Angpt1 Foxo1 Itgb1 Shc1 Pld2 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Prkce Ptpn7 Raf1 Braf Elk1 Mapk8 Map2k2 Prkca Mapk1 Egr1 Map2k1 Fosl1 Hras Mapk3 Jun Il2ra Mapk9 Fos Cd3g Cd247 Il2 Prf1 Cd3d Ifng Faslg Junb Nfatc3 Nfatc2 Il2rg Stat4 Tnfrsf4 Ifnar1 Tnf Eomes Egr4 Prkcq Tnfrsf9 Cd8b Kras Cd8a Ifna1l1 B2m Nras Prkcb SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Rasa1 Src Raf1 Pxn Braf Nck1 Rap1a Rap1b Arhgap35 Ptk2 Grb2 Sos1 Crk Map2k1 Ccnd1 Plcg1 Mapk9 Bmx Map2k4 Itga5 Arhgef11 Asap1 Itgb1 Arhgef28 Arhgap26 Capn2 Rras Ptpn21 Arhgef7 Dock1 Elmo1 Fyn Pik3r1 Yes1 Ets1 Pak1 Acta1 Mapk8 Mapk1 Itgav Jun Rhoa Bcar1 Mapk8ip3 Rac1 Nck2 Git2 Tln1 Actn1 Vcl Rock2 Grb7 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Itgb4 Lama1 Lamb2 Lamb3 Lama3 Lamb1 Lamc1 Itga6 Lama5 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Atm Atr H2ax Ube2t Blm Chek1 Wdr48 Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc4 Rfc2 Rmi1 Hus1 Rpa2 Rad17 Atrip Brip1 Brca2 Rad1 Faap24 Fan1 Fbxw11 Hes1 Btrc Mre11 Fancl Fancc Nbn Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Atm Ada Tp63 Mdm2 Sfn Brca2 Gsk3b Hbp1 Runx1 Dlx5 Dlx6 Bdkrb2 Ppp2r5a Vdr Igfbp3 Hells Sec14l2 Cdkn2a Itch Stxbp4 Hes1 Tcf7l1 Ccnb2 Rrad Krt14 Wwp1 Rab38 Col5a1 Nrg1 Tbxt Adrm1 Il1a Notch1 Axl Perp Mre11 Itga3 Rack1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Sptan1 Apaf1 Diablo Vim Top1 Srebf1 Dffa Dffb Ptk2 Acta1 Birc2 Birc3 Bid Casp8 Limk1 Gsn Casp3 Ripk1 Prf1 Parp1 Map3k1 Madd App Tnfrsf1a Arhgdib Tfap2a Cradd Tnf Slk Numa1 Traf2 Lmnb1 Lmnb2 Cycs Pidd1 Casp7 Bcl2 Krt18 Casp6 Bax Casp4 Casp9 Cfl2 Xiap Satb1 Casp2 Casp1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Tiam1 Arhgef7 Arhgef6 Arhgef2 Dock1 Spata13 Dock2 Elmo1 Abr Eps8 Rap1gds1 Trio Abi1 Prex1 Prex2 Mcf2 Arhgap17 Vav1 Bcr Ralbp1 Arhgap9 Kalrn Arhgef25 Dock6 Arhgap1 Sos1 Rac1 Arhgdia Vav3 Ngef Vav2 Racgap1 Rasgrf2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Itgb2 Hck Rap1a Rap1b Rock1 Lrp1 Selplg Ccn2 Jam3 Plat Ager Icam1 Mst1r Rhoa Apob Thy1 Jam2 Mmp2 Tln1 Selp Mmp9 Mst1 Myh2 Plau Plg Tnf Il6 Nfkb1 Itgam ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Tiam1 Kalrn Nme1 Mapk1 Mapk3 Rhoa Arf1 Rab11fip3 Arf6 Rac1 Rab11a Pld1 Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Rasa1 Raf1 Pxn Ptpn11 Pla2g4a Vav1 Ptk2 Dok1 Ikbkb Grb2 Map2k2 Ikbkg Sos1 Map2k7 Dusp1 Map2k1 Hras Plcg1 Itk Fcer1a Plpp1 Klrg1 Hcls1 Btk Cblb Wipf1 Lat2 Lcp2 Pak2 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Map2k4 Nfkb1 Prkcb Pld2 Rela Lyn Fyn Pik3r1 Mapk8 Mapk1 Mapk3 Jun Inpp5d Fos Syk Cbl Map3k1 Chuk Nfatc2 Sphk1 S1pr1 Gab2 Fer Akt1 Lat Shc1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Src Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Pdgfrb Cxcr4 Vegfa Pdgfb Gna11 Gna15 Gna14 Gna13 Gnaq Mapk1 S1pr3 Mapk3 Rhoa Akt3 Akt1 Rac1 Jak2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Rhoa Madcam1 Itgb7 Itgb1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Tiam1 Frs3 Rasa1 Ntf4 Ntf3 Ptpn11 Rap1a Rap1b Gab1 Frs2 Dnm1 Ntrk2 Grb2 Sos1 Ntrk1 Crk Map2k1 Ntrk3 Hras Ccnd1 Plcg1 Crkl Matk Sqstm1 Faim Prkci Maged1 Dnaja3 Ngfr Shc3 Shc2 Gipc1 Rgs19 Dynlt1 Nedd4l Abl1 Kras Prkcz Arhgap32 Rit1 Rit2 Ehd4 Nras Mcf2l Dock1 Elmo1 Stat3 Pik3r1 Mapk1 Rhog Mapk3 Rhoa Rac1 Gab2 Bdnf Ngf Shc1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Cyth1 Dapp1 Src Inppl1 Plekha1 Plcg2 Lyn Blnk Adap1 Arf5 Fyn Yes1 Fgr Pik3r1 Hck Rap1a Pdpk1 Pik3r6 Pik3cg Hras Rhoa Plcg1 Pten Arf1 Arf6 Rac1 Pik3cb Inpp5d Itk Syk Btk Sgk1 Hsp90aa1 Lck Kras Lat Blk Foxo3 Cyth2 Zap70 Nras Cyth3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Tab2 Stat5a Wwox Fyn Erbb2 Pik3r1 Erbb4 Nedd4 Lrig1 Adam17 Ereg Hbegf Mdm2 Nrg2 Btc Cbfa2t3 Grb2 Nrg4 Mapk1 Nrg3 Dlg4 Grin2b Mapk3 Pik3cb Itch Prl Wwp1 Prlr Nrg1 Stat5b Jak2 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Raf1 Stat5a Lyn Stat3 Ptpn11 Stat1 Pik3r1 Ikbkb Csf2rb Grb2 Map2k2 Mapk1 Cish Sos1 Map2k1 Hras Mapk3 Osm Irf8 Ywhaz Inpp5d Prkaca Fos Pim1 Syk Prkacb Csf2 Stat5b Gab2 Ccl12 Kras Jak2 Nras Shc1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk12 Map2k6 Ccnd1 Mapk13 Map2k3 Eef2k Snta1 Stmn1 Pkn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Enah Egfr Ctnnb1 Nckap1 Cdh1 Git1 Nck1 Abi1 Exoc3 Ctnna1 Rock1 Egf Igf1 Diaph1 Igf1r Rhoa Ctnnd1 Arf6 Efna1 Myl2 Lima1 Vasp Aqp5 Kifc3 Mgat3 Aqp3 Lpp Epha2 Pip5k1c Nectin2 Myo6 Stx4 Actn1 Vcl Zyx Hgf Met Afdn SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Src Raf1 Pxn Braf Grb10 Ptpn11 Nck1 Vegfa Gab1 Ptk2 Pdpk1 Nos3 Rock1 Grb2 Prkca Map2k2 Mapkapk2 Map2k1 Map2k6 Plcg1 Arf1 Prkcd Pak2 Mapk11 Prkcb Ctnnb1 Fyn Pik3r1 Nedd4 Ctnna1 Dnm2 Mapk1 Itgav Mapk3 Rhoa Map2k3 Fbxw11 Prkaca Nck2 Ptpn6 Cbl Ptk2b Vcl Myof Cdh5 Camkk2 Mapk14 Akap1 Sh2d2a Hsp90ab1 Hgs Ptpn2 Fes Vtn Cav1 Hsp90aa1 Akt1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Eif4g1 Gpam Rpl11 Id2 Eif2s1 Supt7l Pfkm Lin28b Myct1 Ccnd2 Kat5 Tfrc Pdcd10 Hspa4 Max Ireb2 Ruvbl2 Eif4a1 Ubtf E2f3 Eif4e Kat2a Mta1 Crebbp Smad3 Smad4 Cdk4 Npm1 Bax Nme1 Ruvbl1 Fosl1 Ccnb1 Pim1 Slc2a1 Mmp9 Snai1 Hmga1 Riox2 Eno1 Bmi1 Ndufaf2 Hsp90aa1 Bcat1 Ddx18 Nbn Shmt1 Tp53 Myc Hspd1 Tert Prdx3 Cad Nme2 Mtdh Actl6a Cdc25a Serpini1 Odc1 Taf9 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Src Lyn Fyn Rala Yes1 Fgr Hck Pak1 Dusp16 Traf6 Pak3 Map3k3 Dusp1 Map3k12 Map2k6 Dusp10 Dusp8 Map2k3 Rac1 Ripk1 Ralb Pak2 Mapk11 Mapk14 Map2k4 Lck Blk SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Raf1 Stat5a Grb10 Lyn Stat3 Ptpn11 Stat1 Pik3r1 Gab1 Vav1 Mitf Pdpk1 Dok1 Grb2 Mapk8 Map2k2 Sos1 Map2k1 Stap1 Bad Hras Mapk3 Epor Epo Ptpro Pten Grap2 Gsk3b Pik3c2b Sh2b2 Map4k1 Ptpn6 Tec Spred1 Cbl Crkl Spred2 Crebbp Rps6kb1 Kit Matk Fer Kitlg Bcl2 Akt1 Jak2 Foxo3 Shc1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Bmp4 Shh Fgf7 Gpc3 Mapk8 Furin Ptch1 Mapk9 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Src Pxn Adam2 Adam12 Vcam1 F13a1 Adam15 Csf2 Adam8 Sat1 Kcnj15 Vegfa Vegfd Vegfc Tgm2 Bcar1 Spp1 Fn1 Rac1 Itga9 Nos2 Itgb1 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc5 Pnkp Polm Nhej1 Dntt Dclre1c Prkdc Aptx Lig4 Aplf Xrcc4 Poll Xrcc6 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Src Raf1 Pxn Ptpn11 Nck1 Rap1a Rap1b Gab1 Eif4ebp1 Ptk2 Pdpk1 Rab5a Grb2 Map2k2 Sos1 Crk Egr1 Map2k1 Eif4e Bad Hras Plcg1 Crkl Pak2 Hgf Prkci Met Map2k4 Rptor Kpnb1 Prkcz Numb Sh3kbp1 Eps15 Rin2 Arhgef4 Pak4 Akt1s1 Muc20 Ctnnb1 Inppl1 Ranbp10 Cdh1 Pik3r1 Ctnna1 Ets1 Pak1 Mapk8 Mapk1 Apc Mapk3 Jun Rhoa Bcar1 Arf6 Rac1 Inpp5d Nck2 Cbl Sh3gl2 Mtor Snai1 Map3k1 F2rl2 Hgs Ptpn2 Ptpn1 Gab2 Akt1 Akt2 Mlst8 Shc1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Egfr Src Gnai1 Gnai3 Stat3 Ptpn11 Stat1 Pik3r1 Nck1 Gab1 Pak1 Ptk2 Egf Grb2 Mapk1 Sos1 Hras Mapk3 Plcg1 Pik3cb Ptpn6 Nck2 Gsn Tln1 Pip5k1c Ptpn1 Kras Nras Shc1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Gnai1 Plcb3 F2r Gnai3 Gna12 Arhgef1 Plcb1 Gnaz Gnao1 Trpc6 Grk3 Gnai2 Snx2 Pik3r1 Snx1 Arrb1 Prkcg Dnm1 Gnb1 Nos3 Rock1 Gna13 Dnm2 Prkca Rhoa Prkcd Myl2 Vasp Arhgdia Pkn1 F2rl2 Rock2 Zyx Gna11 F2 Gna15 Gna14 Gnaq Plcb2 Prkcb SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Lama1 Lama3 Cxcl12 Ptk2 Sdc4 Fgf6 Nudt16l1 Tfpi Dnm2 Prkca Rhoa Prkcd Ccl5 Rac1 Mdk Sdcbp Mmp9 Adam12 Actn1 Cxcr4 Plg Fgf2 F2 Fgfr1 Gipc1 Itga5 Fn1 Itgb1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Rpl11 Atm Hipk2 Atr Ccna2 Kat5 Gsk3b Prkcd Mapk9 Crebbp Nedd8 Cdk2 Yy1 Abl1 Chek1 Mdm2 Mapk8 Smyd2 Cse1l Kat8 Ppp2ca Fbxo11 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Csnk1a1 Csnk1g3 Rassf1 Csnk1g1 Ccng1 Chek2 Csnk1g2 Setd7 Rpl5l1 Cdkn2a Skp2 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Usp7 Daxx Mapk14 Csnk1d Csnk1e Trim28 Tp53 Akt1 Rchy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Gata3 Il5 Egr1 Fosl1 Jun Irf4 Il2ra Fos Batf3 Casp3 Il2 Il4 Cblb Pou2f1 Itch Ifng Cd40lg Maf Egr2 Tbx21 Faslg Rnf128 Csf2 Ctla4 Cdk4 Junb Dgka Nfatc3 Slc3a2 Nfatc2 Egr3 Ptgs2 Foxp3 Ptpn1 Tnf Pparg Egr4 Prkcq E2f1 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Irs1 Gnai1 Gnai3 Gna12 Gnaz Elk1 Gnao1 Cdh5 Mapk14 Gnai2 Gna11 Pak1 Gna15 Gna14 Gna13 Gnaq Mapk8 Mapk1 S1pr2 Jun Mapk3 Rhoa Rac1 Fos NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gnai1 Plcb3 Raf1 Plcg2 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Ptk2 Ar Map2k2 Mapk1 Map2k1 Hras Mapk3 Plcg1 Rac1 Fos Gnrh1 Shbg Pelp1 Akt1 Plcb2 Creb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Tp53 Cdc25c Plk3 Ccne1 Chek2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Itgb4 Lama3 Gja1 Dmtf1 Ccna2 Jund Nos3 Sp1 Fosl1 Jun Ccnd1 Bglap Mmp2 Cdkn2a Mmp9 Plau Mmp1 Junb Nfatc3 Nfatc2 Hmox1 Txlng Usf2 Lif Il6 Dcn Thbd Ccl12 Mgp Atf4 Col1a2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Atm H2ax Blm Kat5 Mdm2 Ywhab Rad17 Bid Chek2 Cdc25c Rbbp8 Trim28 Mre11 Dclre1c Nbn Ctbp1 Xrcc4 Terf2 Abl1 Tp53bp1 Rad50 ABRAXAS1 Fancd2 Ube2n Uimc1 Cdc25a Smc1a Brca1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Apaf1 Nfkbia Rela Mapk8 Map2k7 Cflar Birc3 Bid Casp8 Casp3 Cd247 Ripk1 Fas Fadd Faslg Chuk Daxx Map3k14 Tnfrsf1a Bag4 Cradd Tnf Traf2 Cycs Casp7 Bcl2 Casp6 Nfkb1 Casp9 Casp2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Bgn Sftpa1 Myd88 Vcan Irak4 Tlr6 Chuk S100a9 Cd14 Tirap Tlr4 Tlr3 S100a8 Tlr2 Ikbkb Ikbkg Hspd1 Rhoa Irak2 Irak1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Ifng Stat5a Il6st Gata3 Tbx21 Il1b Stat3 Tgfb1 Stat1 Il12rb2 Ebi3 Il27 Il12a Stat4 Stat2 Il18 Jak1 Il12b Tnf Il6 Jak2 Il2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Ncstn Apaf1 Aph1b Myd88 Diablo Psenen Ntf4 Psen1 Ntf3 Ywhae Zfp110 Ikbkb Traf6 Rhob Birc2 Lingo1 Ikbkg Omg Ntrk1 Mag Mageh1 Bad Smpd2 Bex3 Bex1 Nsmce3 Rtn4 Mapk9 Ripk2 Arhgdia Ndn Casp3 Prdm4 Sort1 Prkacb Mmp7 Furin Mapk10 Plg Sqstm1 Prkci Maged1 Ngfr Cycs Prkcz Pik3r1 Adam17 Mapk8 Rhoa Birc3 Rac1 Bcl2l11 Chuk App Tp53 Akt1 Casp6 E2f1 Bdnf Casp9 Xiap Ngf Shc1 Irak1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Nkd2 Cul3 Ranbp3 Ctnnb1 Dvl1 Klhl12 Pip5k1b Dvl3 Pi4k2a Lrp6 Cav1 Wnt3a Apc Axin1 Fzd5 Gsk3b Csnk1g1 Ppp2r5a Gsk3a FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Src Cdh1 Sdc2 Cttn Ptpn11 Stat1 Pik3r1 Gab1 Frs2 Pdpk1 Camk2a Grb2 Mapk1 Sos1 Mapk3 Jun Plcg1 Ctnnd1 Bglap Fgf19 Spp1 Runx2 Fos Cbl Ptk2b Mmp9 Plau Il17rd Ncam1 Ssh1 Fgfr2 Rps6ka1 Cdh2 Stat5b Fgf23 Fgfr3 Fgfr4 Fgfr1 Spry2 Akt1 Shc1 Pak4 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Smad4 Smad5 Fkbp1a Amhr2 Amh Bmp7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc5 Nrip1 Ar Ncoa2 Ccnd1 Casp8 Uba3 Kdm1a Pawr Hip1 Lats2 Fhl2 Kdm4c Zfp318 Prdx1 Fkbp4 Rps6ka3 Mak Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Snurf Ncoa4 Ncoa6 Ccnd3 Ctnnb1 Kdm3a Tgfb1i1 Tcf4 Ube2i Srf Pias1 Vav3 Gsn Cdkn2a Ptk2b Carm1 Pelp1 Pias3 Tgif1 Prkdc Pias4 Med1 Akt1 Tmprss2 Xrcc6 Cdk6 Brca1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Egfr Src Ctnnb1 Casr Cdh1 Jup Fmn1 Ajuba Zyx Fyn Pik3r1 Ctnna1 Plcg1 Rhoa Ctnnd1 Akt1 Akt2 Rac1 Vasp IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Il6st Stat3 Crp Ptpn11 Stat1 Hsp90b1 Pik3r1 Lbp Hck Mcl1 Ptpre Gab1 Il6r Fgg Vav1 Mitf Tnfsf11 Cebpb Timp1 A2m Jak1 Pias1 Grb2 Sos1 Map2k6 Bcl2l1 Jun Prkcd Rac1 Fos Mapk11 Mapk14 Junb Irf1 Socs3 Pias3 Il6 Gab2 Myc Map2k4 Akt1 Jak2 Foxo1 Lmo4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Efna5 Epha2 Epha3 Epha4 Epha6 Epha7 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Atr Chek1 Ccna2 Rfc5 Rfc3 Rfc4 Mdm2 Mcm7 Rfc2 Smarcal1 Ywhab Ppp2r2b Hus1 Timeless Rpa2 Cep164 Rad17 Ppp2ca Cdc6 Atrip Tipin Brca2 Mcm2 Plk1 Rad1 Clspn Fbxw11 Ywhaz Ppp2r1a Btrc Cdc25c Cdk2 Nbn Rad51 Fancd2 Cdc25a Topbp1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Ctnnb1 Dvl1 Dvl3 Btrc Lrp6 Csnk1d Csnk1e Wnt3a Apc Axin1 Axin2 Fzd5 Cul1 Gsk3b Skp1 Csnk1a1 Gsk3a IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Raf1 Irs2 Grb10 Ptpn11 Pik3r1 Ywhae Ptk2 Pdpk1 Igf1 Grb2 Sos1 Crk Bad Hras Igf1r Bcar1 Prkd1 Prkcd Ywhaz Nck2 Crkl Rps6kb1 Ptpn1 Akt1 Prkcz Shc1 Rack1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Vcam1 Il1b Il18 Tnf Map2k2 Mapk1 Map2k7 Map2k1 Map2k6 Pgr Mapk3 Map2k4 Map2k3 Antxr1 Casp1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Pde6b Guca1a Gnat1 Rgs9 Cnga1 Lrat Rho Gucy2f Sag Gnb1 Rdh12 Rgs9bp Grk1 Gucy2e Rpe65 Gngt1 Slc24a1 Cngb1 Guca1b Pde6a Gnb5 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccna2 Aurkb Sp1 Map2k1 Ccnb1 Ccnd1 Brca2 Plk1 Fos Chek2 Mmp2 Esr1 Cdkn2a Skp2 Crebbp Cdk1 Onecut1 Ccnb2 Foxm1 Rb1 Cks1b Tgfa Etv5 Cdk4 Nfatc3 Lama4 Cdk2 Xrcc1 Cenpa Cenpf Cdc25b Ccne1 Myc Gsk3a IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Prkce Plcb3 Lyn Plcb1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Grk2 Prkca Pik3r6 Pik3cg Cbl Cxcr1 Arrb2 Gna15 Gna14 Akt1 Pld1 Plcb2 Prkcb BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Itgb2 Itgal Fgg Ccn1 Jam3 Plat Icam1 C3 Thy1 Cd40lg Plau Vcam1 Spon2 Proc Gp1ba Fgb Fga F10 Fcgr2a Itgad F11r Icam2 Itgax Kng2l1 Itgam INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Stxbp4 Stx4 Slc2a4 Ins2 Ywhah Ywhag Ywhae Insr Prkci Ywhab Ppp1cc Sfn Asip Trip10 Ppp1r3a Vamp2 Gsk3b Gys1 Akt1 Prkcz Akt2 Lnpep Ywhaz Rhoq PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Tagln Myocd Nckap1 Actn4 Raf1 Nherf2 Nherf1 Wasf2 Sipa1 Cttn Pdgfrb Abi1 Rap1b Pdgfb Arhgap35 Map2k2 Map2k7 Map2k1 Pik3cb Brk1 Arhgdia Baiap2 Arpc1b Actr2 Actr3 Mapk10 Arpc3 Arpc2 Eif2ak2 Arpc5 Arpc4 Map2k4 Blk Jak2 Stat5a Lyn Stat3 Stat1 Fgr Pik3r1 Hck Srf Pak1 Mapk8 Mapk1 Ppp2ca Itgav Mapk3 Rhoa Pten Bcar1 Rac1 Ppp2r1a Pin1 Ptpn1 Csk Shc1 Rasa1 Src Braf Grb10 Elk1 Ptpn11 Eps8 Nck1 Ywhah Rap1a Ywhag Gab1 Pla2g4a Ywhae Dok1 Jund Rab5a Lrp1 Ywhab Grb2 Prkca Sfn Sos1 Crk Hras Plcg1 Prkcd Ywhaz Mapk9 Vav2 Rps6ka3 Abl1 Kras Nras Prkce Fyn Yes1 Ppp2r2b Dnm2 Pik3r6 Pik3cg Jun Nck2 Fos Cbl Stat5b Ptpn2 Sphk1 S1pr1 Myc Lck Sla Afdn Arap1 Rab4a Usp6nl ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 Src Ctnnb1 Pip5k1c Nectin2 Vav2 Cdh1 Nectin1 Nectin3 Ptprm Pdgfrb Pik3r1 Cldn1 Rap1a Rap1b Pdgfb Ctnna1 Ptk2 Farp2 F11r Crk Itgav Rac1 Afdn BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Rasa1 Raf1 Elk1 Cd72 Cd22 Malt1 Cd79b Bcl2a1 Pdpk1 Dok1 Bcl10 Ptprc Nfkbib Ikbkb Traf6 Ppp3cc Grb2 Ppp3cb Ikbkg Sos1 Sh3bp5 Map2k1 Hras Map4k1 Btk Vav2 Fcgr2b Nfkb1 Csnk2a1 Dapp1 Nfkbia Rela Plcg2 Blnk Lyn Pik3r1 Ets1 Mapk8 Mapk1 Mapk3 Jun Pten Map3k7 Rac1 Inpp5d Fos Ptpn6 Syk Map3k1 Chuk Mapk14 Camk2g Csk Ppp3ca Akt1 Shc1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Mcf2l Arhgef1 Arhgef2 Abr Trio Mcf2 Vav1 Arhgap35 Bcr Arhgap9 Ect2 Arhgef25 Srgap1 Arhgef5 Arhgef3 Ophn1 Rhoa Arhgdig Arhgef12 Arhgef18 Farp1 Arhgdia Vav3 Net1 Arhgef15 Arhgap4 Arhgap8 Ngef Vav2 Arhgap5 Arhgdib Cdkn1b Arhgef11 Arhgef28 Arap1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Stxbp1 Unc13b Chrna1 Snap25 Syt1 Rab3gap2 Stx1a Vamp2 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Ncstn Aph1b Gata3 Psenen Dnm1 Ccnd1 Cul1 Skp1 Rab11a Cbl Il4 Maml1 Maml2 Skp2 Itch Furin Adam12 Btrc Ptcra Dll1 Mark2 Dll3 Dll4 Kdm1a Adam10 Rbbp8 Neurl1 Yy1 Cdkn1a Mfap5 Notch1 Jag2 Jag1 Eno1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Ctbp1 Notch2 Myc Notch3 Hdac1 Dner Lnx1 Numb Eps15 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccnd3 Stat5a Elf1 Ccna2 Ptpn11 Ccnd2 Pik3r1 Jak3 Jak1 Grb2 Sp1 Sos1 Bcl2l1 Il2ra Lta Il2 Prf1 Il4 Faslg Il2rg Stat5b Foxp3 Gab2 Myc Lck Bcl2 Cdk6 Shc1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Src Raf1 Stat3 Ptpn11 Erbb2 Pik3r1 Nrg2 Grb2 Mapk8 Ppp3cb Map2k2 Mapk1 Sos1 Map2k1 Bad Hras Mapk3 Jun Rac1 Pik3cb Mapk9 Prkaca Fos Mtor Chrna1 Mapk10 Nrg1 Kras Akt1 Erbb3 Nfatc4 Jak2 Nf2 Chrne Usp8 Nras Shc1 Rnf41 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Cxcr2 Rab7a Rac2 Plcb3 Lyn Plcb1 Dock2 Elmo1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Prkca Pik3r6 Pik3cg Ppp2ca Rab11a Vasp Cbl Ppp2r1a Arrb2 Gna15 Gna14 Akt1 Plcb2 Pld2 Prkcb FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc2 Sdc4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Lamb1 L1cam Cd47 Ibsp Pdgfrb Vegfa Pdgfb Fgg Sdc4 Ccn1 Itgav Spp1 Thy1 Col1a1 Col4a3 Plau Col4a1 Lama4 Lamc1 Col4a5 Vtn Fgb Sdc1 Fga F11r Sphk1 Fn1 Tgfbr2 Itga2b Col1a2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Rasa1 Irs1 Raf1 Irs2 Ptpn11 Grb2 Map2k2 Sos1 Mapkapk2 Map2k1 Hras Mapk9 Mapk11 Cdk2 Socs3 Kras Nras Prkcb Prkce Stat5a Stat3 Fyn Stat1 Socs2 Pik3r1 Stam2 Ikzf3 Stam Jak3 Jak1 Mapk8 Mapk1 Cish Mapk3 Jun Rhoa Il2ra Fos Syk Il2 Ptk2b Ifng Mapk14 Il2rg Stat5b Gab2 Myc Lck Bcl2 Shc1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Chek1 Csnk1e Npas2 Nr1d1 Nono Cry1 Cry2 Clock Bmal1 Timeless Per2 Per1 Wdr5 Bhlhe40 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Il12rb2 Il12a Map2k6 Ripk2 Cd3g Cd247 Cd3d RT1-Da Tbx21 RT1-Db1 Stat4 Il18 Il12b Eomes Cd4 Cd8b Sphk2 Cd8a Nfkb1 B2m Jak2 Nos2 Rab7a Rela Stat5a Il18r1 Il1b Stat3 Stat1 Stat6 Nfkb2 Ccr5 Gadd45g Gzma Map2k3 Il2ra Gadd45b Hlx Fos Ccl4 Il1r1 Il2 Il4 Mtor Ifng Faslg Mapk14 Il2rg Atf2 Lck BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Sdc1 Plau Itgb8 Vcam1 Itgav Itgb6 Madcam1 Itgb7 Tgfbr1 Fn1 Vtn Ccn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Irs1 Src Pxn Ptpn11 Vegfa Ptk2 Rock1 Igf1 Col11a1 Igf1r Col11a2 Casp8 Col2a1 Col3a1 Col1a1 Col4a3 Col5a2 Col6a2 Col4a1 Col5a1 Fgf2 Col4a5 Sdc1 Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Vav3 Angptl3 Cbl Mfge8 Tln1 Pi4kb Ptk2b Pik3c2a Rps6kb1 Vcl Csf1 Vtn Csf1r Hsp90aa1 F11r Akt1 Fn1 Tgfbr2 Col1a2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Crebbp Tubb2a Mef2d Acss1 Myod1 Cdkn1a Hdac4 Fhl2 Tp53 Sirt3 Sirt2 Sirt1 Bax Ppargc1a Foxo4 Foxo3 Foxo1 Xrcc6 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rara Nrip1 Prkcg Ncoa2 Ncoa1 Mapk8 Prkca Mapk1 Mapk3 Prkaca Vdr Crebbp Cdk1 Mnat1 Ccnh Mapk14 Cdk7 Rbp1 Hdac3 Rxrb Rxra Hdac1 Rarg Akt1 Rxrg HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Cdkn2a Vhl Eloc Rbx1 Hif3a Os9 Cops5 Naa10 Cul2 Hsp90aa1 Tp53 Arnt Hif1an Egln2 Egln3 Hif1a Rack1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Foxa1 Foxa2 Foxa3 Col18a1 Nrip1 Cebpb Ap1b1 Ar Shh Sp1 Dscam Jun Tff1 Apob Atp5pf Fos Xbp1 Esr1 Sod1 Pou2f1 Crebbp Ndufv3 Prdm15 Ins2 Vtn Pisd Sftpd Nfib Cdkn1b Nfia Nfic Scgb1a1 Nr2f2 Gcg C4bpb Serpina1 Nkx3-1 Brca1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Tab2 Ror2 Yes1 Rock1 Camk2a Mapk8 Rhoa Csnk1a1 Map3k7 Rac1 Mapk9 Dvl1 Dvl3 Mapk10 Nfatc2 Arrb2 Wnt5a Nlk Pparg Cthrc1 Fzd2 Fzd5 Prkcz Daam1 Flna Fzd6 Chd7 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Src Gnai1 Plcb3 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Hbegf Nos3 Igf1 Gna13 Grb2 Sos1 Hras Msn Igf1r Rhoa Bcar1 Mmp2 Esr1 Esr2 Mmp9 Rock2 Mapk11 Gna11 Gna15 Pelp1 Gna14 Gnaq Kras Akt1 Gnal Plcb2 Strn Nras Shc1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Myog Mdfic Igf2bp1 Cby1 Vcan Id2 Fgf4 Zcchc12 Tbl1xr1 Kcnip4 Tnik Adcy7 Ccnd2 Mt-co2 Camk4 Ywhah Tle4 Ywhag Med12 Ywhae Tle2 Mitf Krt1 Ruvbl2 Tle5 Dkk4 Ar Ywhab Chd8 Ncoa2 Smarca4 Tcf7 Tbl1x Sfn Sp5 Cdx4 Axin2 Cdx1 Ccnd1 Ctnnbip1 Klf4 Hbp1 Pitx2 Ywhaz Myf5 Dvl3 Tle1 Dkk1 Ctnnb1 Tcf4 Cdh1 Incenp Xpo1 Tcf7l2 Ccn1 Apc Jun Cul1 Skp1 Mmp2 Cdkn2a Mmp9 Tcf7l1 Btrc Tbxt Lef1 Hdac2 Ctbp1 Myc Tert Hdac1 Neurog1 Cacna1g EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Irs2 Plcg2 Stat5a Lyn Ptpn11 Stat1 Pik3r1 Rap1a Gab1 Grb2 Mapk8 Sos1 Bcl2l1 Hras Epor Epo Plcg1 Inpp5d Ptpn6 Tec Cbl Crkl Btk Vav2 Mapk14 Stat5b Socs3 Bcl2 Nfkb1 Jak2 Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k10 Tab2 Atm Map3k1 Mapk11 Mapk14 Txn Gadd45a Traf6 Map3k3 Camk2b Traf2 Map2k6 Gadd45g Map2k3 Gadd45b Map3k7 Rac1 Taok1 Taok3 Map3k6 Map3k4 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Cdkn2a Skp2 Pin1 Supt7l Pak2 Zbtb17 Kat5 Max Ruvbl2 Ppp2ca Ruvbl1 Myc Axin1 Gsk3b Hbp1 Actl6a Kat2a Ppp2r5a Taf9 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Gnai1 Gnai3 Gnaz Gnao1 Gnai2 Pdgfrb Vegfa Ptgs2 Pdgfb Abcc1 Sphk1 Mapk1 S1pr1 Mapk3 Plcg1 Rhoa Rac1 Plcb2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Prnp Lama1 Pla2g2a Src Slit2 Smad2 Serpinc1 Lyn Cripto Tgfb1 Fyn Yes1 Fgr Tgfb3 Nrg1 Hck Fgf2 Vegfa App Fgfr1 Lck Blk Tgfbr1 Tgfbr2 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Gnai1 Src Raf1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Pla2g4a Prkca Map2k2 Crk Map2k1 Hras Prkcd Col3a1 Ednrb Ednra Mmp1 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Edn2 Edn3 Prkch Cysltr2 Cysltr1 Prkcq Jak2 Plcb2 Prkcb Prkce Plcb3 Edn1 Plcb1 Trpc6 Prkcg Slc9a1 Mapk8 Slc9a3 Mapk1 Mapk3 Jun Rhoa Bcar1 Rac1 Fos Ptk2b Mapk14 Gna11 Gna15 Gna14 Gnaq Akt1 Gnal Col1a2 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Pgf Vegfa Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Trpc6 Fyn Tjp1 Pik3r1 Nck1 Grb2 Mapk8 Bad Jun Plcg1 Rac1 Pik3cb Mapk9 Nck2 F2rl2 Mapk10 Arrb2 Prkci Nphs2 Map2k4 Nphs1 Akt1 Prkcz Cd2ap Kirrel1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Tiam1 Egfr Gnai1 Src Pxn Nherf2 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Gab1 Ptk2 Crk Hras Plcg1 Gsk3b Prkcd Pik3cb Casp3 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Nfkb1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Pld2 Prkce Nfkbia Plcb3 Rela Arhgef1 Lyn Pik3r1 Gnb1 Hbegf Gna13 Jun Rhoa Bcar1 Prkd1 Rac1 Fos Mmp2 Ptk2b Mmp9 Gna11 Gna15 Gna14 Gnaq Akt1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Lama1 Lama3 Col18a1 Vegfa Col11a1 Col11a2 Mdk Jam2 Col2a1 Cd81 Col3a1 Col1a1 Col4a3 Col5a2 Vcam1 F13a1 Col6a2 Igsf8 Cd14 Thbs2 Col4a1 Col5a1 Lamc1 Col4a5 Tgm2 Lama5 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Itga9 Itgb1 Nid1 Lamb2 Itga1 Cspg4 Lamb3 Itga2 Lamb1 Fgg Itgav Spp1 Plau Lama4 Vtn Fgb Fga Fn1 Col1a2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Egfr Src Ctsg Itgb2 Fpr1 Klk4 Fpr3 Fpr2 Dock1 Serpine1 Gpld1 Mmp12 Pdgfrb Mmp13 Ctrc Vldlr Fgg Lrp1 Crk Itgav Bcar1 Rac1 Mmp9 Plau Tgfb1 Hgf Plg Vtn Elane Fgb Fga Itga3 Itga5 Fn1 Itgb1 Itgam VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Rbl1 Id2 Pdgfrb Max Gadd45a Sp1 Ccnd1 Cflar Ccl5 Smad2 Smad3 Smad4 Zbtb17 Hdac3 Cdkn1a Wnt5a Dntt Cdkn1b Lgals1 Itga6 Itgb1 Dkk1 Itgb4 Erbb2 Spi1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Tmem126a Sfrp1 Tbp Csde1 Tsc2 Hmgcs2 Nfyb Irf8 Nfya Ptpa Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Cebpa Myc Hdac1 Bcl2 Cdkn2b Foxo3 Creb1 Col1a2 Brca1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Egfr Areg Tgfa Erbb2 Erbb4 Nrg1 Ereg Hbegf Egf Nrg2 Btc Hsp90aa1 Nrg4 Nrg3 Erbb3 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Camk4 Nr3c1 Ranbp2 Xpo1 Ywhae Hdac4 Gnb1 Srf Ube2i Ran Ywhab Grk2 Esr1 Ankra2 Tubb2a Rfxank Mef2c Hdac3 Hdac11 Bcl6 Hdac10 Hdac7 Gata1 Hsp90aa1 Gata2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Tab2 Ctnnb1 Ywhae Pdpk1 Camk2a Ccn2 Grb2 Sos1 Ppp2ca Fkbp1a Map3k7 Itch Smad2 Rps6kb1 Smad3 Strap Dynlrb1 Smad4 Daxx Dab2 Dact2 Tgfb1 Wwp1 Tgfbrap1 Tgfb3 Zfyve16 Ppp2cb Arrb2 Tgfbr3 Ppp1ca Sptbn1 Ppp2r2a Smad7 Cav1 Rnf111 Ppp1r15a Zfyve9 Bambi Axin1 Nedd4l Smurf1 Tgfbr1 Tgfbr2 Xiap Shc1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Map3k1 Lcp2 Map3k8 Mapk8 Dbnl Crk Jun Map2k4 Grap2 Lat Map3k7 Map4k1 Crkl Prkcb ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkce Nr4a1 Map3k8 Camk4 Ywhah Ywhag Xpo1 Prkcg Ywhae Ran Ywhab Mapk8 Prkca Sfn Bad Bcl2l1 Mapk3 Chp1 Rcan2 Gsk3b Fkbp1a Prkcd Csnk1a1 Ywhaz Mapk9 Prkaca Casp3 Pim1 Cabin1 Crebbp Map3k1 Mef2d Akap5 Mapk14 Nfatc3 Nfatc2 Prkch Fkbp8 Prkcq Kpna2 Bcl2 Kpnb1 Prkcz Bax Csnk2a1 Prkcb TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Map3k8 Ptpn11 Nck1 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Itk Map4k1 Cd3g Cd247 Cd3d Cd28 RT1-Da Cd86 Lcp2 Cd80 RT1-Db1 Prkcq Cd4 Kras Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Pten Inpp5d Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Dbnl Gab2 Sla2 Orai1 Lck Stim1 Akt1 Stk39 Lat Flna Rassf5 Fyb1 Sh3bp2 Shc1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Pik3r1 Nck1 Vegfa Nos3 Cav1 Pdpk1 Hsp90aa1 Nrp1 Shc2 Prkca Nrp2 Mapk1 Pgf Mapk3 Plcg1 Akt1 Cd2ap Prkaca Hif1a Cbl Prkcb EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Egf Mtor Egfr Grb2 Edn1 Sos1 Hras Ednra Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Ift88 Kif3a Stk36 Gnai1 Sufu Foxa2 Spop Gnai3 Gnaz Gnao1 Gnai2 Xpo1 Gnb1 Gli2 Shh Pias1 Smo Ptch1 Map2k1 Sap18 Gsk3b Prkcd Csnk1a1 Fbxw11 Csnk1g3 Prkaca Csnk1g1 Csnk1g2 Rbbp7 Crebbp Btrc Csnk1d Arrb2 Csnk1e Hdac2 Hdac1 Akt1 Lgals3 Rab23 Gli1 Mtss1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Grb10 Ptpn11 Pik3r1 Nck1 Exoc3 Eif4ebp1 Exoc5 Pdpk1 Exoc6 Dok1 Exoc2 Grb2 Sos1 Crk Exoc7 Hras Sh2b2 Inpp5d Nck2 Cbl Ptpra Rps6kb1 F2rl2 Ins2 Grb14 Sgk1 Insr Prkci Cav1 Ptpn1 Trip10 Akt1 Prkcz Akt2 Rhoq Foxo3 Shc1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfc Pdgfra Pdgfrb Pdgfb EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Tiam1 Src Epha2 Inppl1 Vav2 Acp1 Pik3r1 Arhgap35 Ptk2 Pak1 Grb2 Rhoa Bcar1 Efna1 Rac1 Vav3 Shc1 Cbl ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Egfr Src Nckap1 Raf1 Braf Wasf2 Elk1 Arf4 Ppp5c Eps8 Diaph3 Atf1 Zfp36 Abi1 Ywhah Map3k2 Ywhag Gab1 Myl11 Ywhae Map2k5 Dusp6 Pdpk1 Rab5a Ralgds Egf Ywhab Grb2 Prkca Map2k2 Sos1 Sfn Dusp1 Egr1 Map2k1 Bad Hras Rps6ka5 Prkcd Ywhaz Pik3cb Mapk9 Brk1 Baiap2 Arpc1b Actr2 Vav2 Actr3 Mef2c Arpc3 Arpc2 Arpc5 Arpc4 Rps6ka3 Map2k4 Kras Prkcz Pld1 Nras Pld2 Capn2 Pebp1 Rin1 Stat3 Stat1 Rala Pik3r1 Srf Slc9a1 Mapk8 Mapk1 Ppp2ca Bcl2l1 Mapk3 Jun Rac1 Fos Mtor Ppp2r1a Map3k1 F2rl2 Sh2d2a Atf2 Ppp2r2a Smad1 Rps6 Rictor Akt1 Mapkap1 Creb1 Mlst8 Usp6nl LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Nudc Cdk5 Vldlr Map1b Ywhae Ppp2r5d Katna1 Pafah1b3 Pafah1b2 Lrp8 Lrpap1 Pafah1b1 Dab1 Dync1h1 Dynlt1 Cdk5r1 Rhoa Ndel1 Abl1 Reln Dcx Csnk2a1 Rac1 Pla2g7 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Atf5 Itga1 Src Ccna2 Cdk2 Cdkn1a Ccne1 Rock1 Agt Mapk1 Egr1 Mapk3 Rhoa Bcar1 Rac1 Ptp4a3 Ptp4a1 Itgb1 Rabggta Rabggtb EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Tiam1 Rgs3 Src Ephb1 Lyn Ephb2 Ptpn13 Efnb1 Fyn Efnb2 Yes1 Fgr Pik3r1 Hck Dnm1 Mapk8 Map2k4 Lck Blk Map3k7 Rac1 Nck2 Itga2b VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Itga1 Col1a1 Itga2 Mapk11 Mapk14 Pik3r1 Rps6ka1 Vegfd Vegfc Grb2 Mapk1 Sos1 Flt4 Crk Mapk3 Map2k4 Itga5 Akt1 Fn1 Itgb1 Creb1 Col1a2 Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Egfr Src Pxn Tshr Adap1 Adrb2 Git1 Nck1 Acap1 Arrb1 Agtr1 Egf Arf6 Efna1 Gulp1 Epha2 Fbxo8 Acap2 Lhcgr Arap2 Hgf Arrb2 Gna11 Gna15 Gna14 Met Gnaq Cyth2 Itga2b Cyth3 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Ada Tp63 Serpine1 Ccna2 Kat5 Sp1 Sfn Ntrk1 Plk3 Plpp1 Hey2 Fas Prkacb Mapk11 Rb1 Pfdn5 Tuba1a Ccne2 Cdk2 Pea15 Il1rap Ndufs2 Cdkn1a Hagh Gramd4 Jag2 Aen Dcp1b Gata1 Rnf43 Dedd Flot2 Afp Hsf1 Wt1 Nedd4l Bak1 Sirt1 Abl1 Ube4b Tp73 Bax Nsg1 Gdf15 Rela Chek1 Wwox Mdm2 Jak1 Bub1 Ccnb1 Bin1 Brca2 Plk1 Bcl2l11 Itch Pin1 Cdk1 Mapk14 Il4r Myc Serpina1 Rad51 Foxo3 Rchy1 Casp2 Cdk6 Rack1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Cxcl13 Src Gnai1 Raf1 Gnai3 Gnaz Gnao1 Gnai2 Pik3r1 Arrb1 Dnm1 Gnb1 Pdpk1 Map2k2 Mapk1 Map2k1 Map2k6 Hras Mapk3 Map2k3 Pik3cb Mtor Ccl11 Mapk11 Mapk14 Cxcl9 Rictor Kras Akt1 Cxcl11 Cxcl10 Mapkap1 Cxcr3 Nras Pf4 Mlst8 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Cnksr1 Il3ra Prkacb Srp9 Stat5a Ptpn11 Pik3r1 Stat5b Id1 Ywhag Cebpb Csf2rb Grb2 Cish Gab2 Bcl2l1 Osm Hdac1 Jak2 Ywhaz Inpp5d Prkaca Shc1 Pim1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Egfr Src Nherf1 Gna12 Gnai2 Dnm1 Nos3 Rock1 Egf Sele Grk2 Prkca Icam1 Prkcd Rab11a Vcam1 Mapk11 Tgm2 Prkch Prkcq Arr3 Prkcz Blk Plcb2 Prkcb Gnb5 Prkce Ptgdr Ptgir Arhgef1 Lyn Tbxa2r Grk3 Fyn Fgr Yes1 Hck Prkcg Gnb1 Gna13 Pik3r6 Pik3cg Rhoa Rac1 Prkaca Syk Mapk14 Arrb2 Gna11 Gna15 Gna14 Gnaq Lck Akt1 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Itgb4 Lamb2 Egfr Lama1 Lamb3 Lama3 Lamb1 Cdh1 Col17a1 Pmp22 Erbb2 Pik3r1 Ywhah Ywhag Ywhae Egf Ywhab Grb2 Prkca Sfn Hras Mst1r Rac1 Ywhaz Rps6kb1 Mst1 Lama4 Lamc1 Il1a Lama5 Met Rxrb Rxra Casp7 Akt1 Erbb3 Rxrg Itga6 Itgb1 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Irs1 Raf1 Srebf1 Braf Ywhah Ywhag Eif4ebp1 Ywhae Eif4a1 Pdpk1 Ywhab Ikbkb Prkca Map2k2 Sfn Map2k1 Eif4e Hras Ppargc1a Ywhaz Cdk2 Rps6ka1 Yy1 Cycs Rptor Kras Pld1 Nras Pld2 Akt1s1 Prr5 Rraga Ddit4 Rragb Rragc Rragd Tsc1 Eif4b Ulk1 Ulk2 Rb1cc1 Mapk1 Rrn3 Tsc2 Poldip3 Pdcd4 Mapk3 Bnip3 Atg13 Eef2 Eef2k Fbxw11 Mtor Rps6kb1 Btrc Sgk1 Ccne1 Rictor Akt1 Mapkap1 Mlst8 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Btrc Chuk Nfkb2 Map3k14 Nfkb1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Egfr Tp63 Col18a1 Serpine1 Atf3 Bcl2a1 Pou4f1 E2f3 Pou4f2 Cd82 Sp1 Plk3 Bid Kat2a Vdr Fas Crebbp Rb1 Ctsd Cdkn1a Afp Bak1 Tp73 Bax Gdf15 Foxa1 Ddit4 Mdm2 Cse1l Apc Ccnb1 Pten Drosha Spp1 Ccnk Pcbp4 Tap1 Bdkrb2 Ccng1 Hic1 Ppp1r13b Igfbp3 Msh2 Mmp2 Tnfrsf10b Sh2d1a Sesn1 Steap3 Tada2b Fdxr Ddx5 Btg2 Rrm2b Tp53bp2 Prmt1 Bcl2l14 Carm1 Gpx1 Bcl2l2 Perp Cav1 Bnip3l Rnf144b Triap1 Irf5 Lif Aifm2 Dgcr8 Tp53 Htt Scn3b Pidd1 Zfp385a Pms2 Cx3cl1 Pycard Pcna Mlh1 Tp53inp1 Tigar Rchy1 Nlrc4 Casp1 Prdm1 Prkab1 Apaf1 Ppm1j Vcan Serpinb5 Gadd45a Smarca4 Dusp5 Sfn Dusp1 Epha2 Hgf Edn2 Met Dkk1 Mcl1 Tsc2 Bcl2l1 Jun Nfyb Nfya Nfyc Ndrg1 Tgfa Bcl6 Hdac2 Bcl2 Casp6 E2f1 Taf9 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkce Adcy3 Adcy4 Adcy7 Adcy2 Adcy8 Adcy5 Adcy6 Rps6ka5 Lpar4 Prkaca Gnal Creb1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Tiam1 Rab7a Egfr Src Slit1 Ctnnb1 Cbll1 Dsp Gna12 Cdh1 Cables1 Jup Igf2 Gdnf Robo1 Fyn Zbtb33 Gfra1 Snx1 Ctnna1 Rab5a Egf Nme1 Gna13 Ntrk2 Dnm2 Hras Igf1r Ctnnd1 Arf6 Rac1 Ptpn6 Casp3 Crebbp Mmp7 Cdh2 Adam10 Hgs Ptpn1 Met Abl1 Bdnf Ret Rin2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Arhgef7 Ajuba Aurkaip1 Aurkb Oaz1 Git1 Cpeb1 Dlgap5 Fzr1 Tdrd7 Pak1 Mdm2 Ran Gadd45a Ndel1 Gsk3b Prkaca Tpx2 Tacc3 Ckap5 Aurka Cenpa Cdc25b Ppp2r5d Tp53 Akt1 Tacc1 Brca1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Rela Stat5a Pik3r1 Fcamr Traf3 Jak3 Cd40 C4bpa Traf6 Tdp2 Mapk8 Birc2 Pik3r6 Pik3cg Bcl2l1 Jun Birc3 Pik3cb Mapk9 Il4 Cblb Map3k1 Cd40lg Mapk10 Mapk11 Map3k14 Mapk14 Traf2 Myc Map2k4 Akt1 Nfkb1 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Ncoa2 Esr2 Ncoa1 Smarca4 Nr0b2 Nr0b1 Smarcb1 Zfp709 Uba3 Smarce1 Nedd8 C3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkc Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Akt1s1 Ywhah Ywhag Ywhae Tsc1 Ywhab Sfn Stk11ip Tsc2 Stk26 Mark4 Crtc2 Map2 Gsk3b Stradb Smarcd3 Ywhaz Cab39 Prkaca Strada Etv4 Stk11 Esr1 Psen2 Mtor Sik1 Brsk2 Ezr Brsk1 Smad4 Mark2 Cdc37 Ctsd Hsp90aa1 Tp53 Myc Rptor Creb1 Mlst8 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb1 Ephb2 Ephb3 Efnb1 Efnb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Raf1 Braf Elk1 Ntf3 Rap1a Rap1b Map3k2 Map2k5 Srf Trpv1 Mapk1 Mapkapk2 Egr1 Map2k1 Map2k6 Hras Mapk3 Cdk5r1 Rps6ka5 Map2k3 Prkcd Fos Mef2c Mapk14 Cdk5 Rps6ka1 Kras Rit1 Rit2 Ehd4 Creb1 Nras TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Tab2 Rela Tnik Stat1 Adam17 Ikbkb Birc2 Ikbkg Map3k3 Map2k7 Smpd2 Birc3 Map2k3 Map3k7 Casp8 Ripk1 Fadd Map3k1 Nrk Map4k5 Map4k3 Chuk Tnfrsf1b Cyld Map4k2 Rffl Sqstm1 Nsmaf Madd Prkci Cav1 Smpd1 Txn Tnfrsf1a Bag4 Tnf Traf2 Prkcz Nfkb1 Rack1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Hadh Foxa1 Foxa2 Foxa3 Tfrc Nr3c1 Cebpb Sp1 Ins2 G6pc1 Pklr Tat Aldob Hnf4a Nkx2-1 F2 Cebpa Acadvl Hmgcs1 Ttr Dlk1 Igfbp1 Slc2a2 Afp Ucp2 Nf1 Pck1 Acadm Gck Cpt1a Akt1 Bdh1 Abcc8 Kcnj11 Alb Hnf1a Creb1 Cpt1b Cpt1c CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Tiam1 Enah Src Raf1 Braf Eps8 Diaph3 Dlg1 Map2k7 Map2k6 Hras Gsk3b Mapk9 Arhgdia Baiap2 Iqgap3 Arpc1b Actr2 Vav2 Actr3 Pak2 Arpc3 Arpc2 Arpc5 Arpc4 Map3k11 Map2k4 Prkcz Pld1 Pak4 Cdc42bpa Prkce Ctnnb1 Septin2 Pax6 Arhgef7 Hes5 Cdh1 Tnk2 Arhgef6 Pik3r1 Yes1 Ctnna1 Pak1 Mapk8 Mapk1 Apc Cfl1 Exoc7 Mapk3 Jun Bcar1 Map2k3 Rac1 Myl2 Limk1 Limk2 Cbl Mtor Map3k1 Rps6kb1 F2rl2 Mapk14 Atf2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Gnai1 Src Pxn Gnai3 Gnaz Gnao1 Gnai2 Ptpn11 Rap1b Dnm1 Vav1 Ptk2 Pdpk1 Ptprc Stat2 Rhob Grk2 Crk Bad Pik3cb Cd3g Cd247 Cd3d RT1-Da RT1-Db1 Ssh1 Cxcr4 Cd4 Arr3 Prkcz Blk Jak2 Plcb2 Plcb3 Stat5a Lyn Plcb1 Rgs1 Ubqln1 Stat3 Vps4a Fyn Stat1 Fgr Vps4b Pik3r1 Yes1 Hck Grk6 Gnb1 Cxcl12 Pak1 Gna13 Pik3r6 Pik3cg Cfl1 Rhoa Bcar1 Rac1 Inpp5d Limk1 Ptpn6 Mtor Ptk2b Mmp9 Itch Ralb Stat5b Hgs Arrb2 Csk Lck Rictor Akt1 Foxo1 Mapkap1 Rack1 Mlst8 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Th Raf1 Mapk11 Mapk14 Etv1 Ywhah Tcf3 Cdc25b Lsp1 Ywhag Ywhae Srf Ywhab Hspb1 Mapkapk3 Mapkapk2 Sfn Tsc2 Ywhaz Creb1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Ncstn Dkk1 Aph1b Ctnnb1 Psenen Psen1 Nedd4 Dkk2 Tle5 Mapk1 Apc Mapk3 Jun Ccnd1 Gsk3b Csnk1a1 Map3k7 Fbxw11 Fos Dvl1 Crebbp Btrc Dll1 Tle1 Lrp6 Adam10 Notch1 Nlk Wif1 Ppp2r5d Wnt1 Fzd1 Ctbp1 Myc Axin1 Hdac1 Kremen2 Csnk2a1 Hnf1a Ppard VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Itgb4 Ada Cables1 Tp63 Serpinb5 Dhrs3 Traf4 Mdm2 Ogg1 Spata18 Gadd45a Shh Ikbkb Tfap2c Nqo1 Sp1 Noc2l Ssrp1 Dicer1 Plk1 Hbp1 Prkcd Smarcd3 Vdr Igfbp3 Mfge8 Cdkn2a Fas Itch Btrc Egr2 Fdxr Chuk Wwp1 Cdkn1a Jag1 Aen Perp Flot2 Itga3 Abl1 Bax Gdf15 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Il1b Stat3 Ptpn11 Stat1 Pik3r1 Ifngr1 Rap1a Rap1b Dapk1 Cebpb Camk2a Jak1 Pias1 Mapk1 Map2k1 Mapk3 Irf9 Prkcd Camk2d Cbl Crkl Mtor Crebbp Ifng Map3k1 Irf1 Ptpn2 Camk2g Smad7 Map3k11 Pias4 Camk2b Akt1 Jak2 Casp1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Cltb Arfgap1 Cd4 Ap2m1 Arf1 Gbf1 Uso1 Gga3 Rac1 Kdelr1 Asap1 Cyth2 Ap2a1 Clta Arfip2 Pld2 Gosr2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Tab2 Myd88 Rela Irak4 Il1b Pik3r1 Ikbkb Traf6 Mapk8 Ikbkg Map3k3 Map2k6 Jun Map3k7 Il1r1 Ube2v1 Ticam2 Irak3 Erc1 Tollip Chuk Il1r2 Il1rn Il1rap Sqstm1 Il1a Prkci Prkcz Nfkb1 Ube2n Irak1 Casp1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Nr4a1 Gata3 Pomc Ppp5c Ywhah Nr3c1 Ncoa2 Smarca4 Sele Ncoa1 Il5 Sfn Egr1 Icam1 Cdk5r1 Gsk3b Bglap Mapk9 Il13 Prkacb Crebbp Mapk10 Mapk11 Tbx21 Mmp1 Cdk5 Irf1 Cdkn1a Fkbp4 Afp Il6 Bax Nfkb1 Rela Stat5a Stat1 Spi1 Fgg Mdm2 Mapk8 Tbp Mapk1 Mapk3 Jun Prkaca Fos Il2 Il4 Pou2f1 Ifng Csf2 Krt14 Prl Mapk14 Nr1i3 Tsg101 Kmt5b Sgk1 Stat5b Fkbp5 Csn2 Sumo2 Pou1f1 Cga Pck2 Krt17 Hsp90aa1 Hdac2 Pbx1 Smarcc2 Tp53 Hdac1 Akt1 Smarcc1 Creb1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Ube2d3 Egfr Src Raf1 Arhgef7 Pik3r1 Lrig1 Synj1 Dnm1 Ptk2 Itsn1 Rab5a Egf Grb2 Sos1 Hras Pik3cb Ube2d1 Cbl Sh3gl2 Cblb Tsg101 Hgs Stambp Amph Spry2 Chmp3 Epn1 Kras Ube2d2 Zfyve28 Sh3kbp1 Eps15 Usp8 Nras Shc1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Tfe3 Sult2a1 Ranbp1 Apaf1 Rbl1 Ces2h Atm Mcm3 Ces4a Dhfr Serpine1 Orc1 Ces5a Ccna2 Rrm2 E2f6 E2f7 E2f3 Sp1 Hbp1 Kat2a Crebbp Rb1 Wasf1 Ccne2 Cdk2 Rbbp8 Yy1 Cdkn1a E2f5 Cdkn1b Cbx5 Sirt1 Tp73 Ccnd3 Mcl1 Cdc6 Hic1 Cdkn2a Plau Cdk1 Rbl2 Smarca2 Xrcc1 Ccne1 Trim28 Cebpa Myc Hdac1 Casp7 E2f1 Uxt Tfdp2 Ces1d Cdc25a Cdkn2c Topbp1 Tyms Mybl2 Brca1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Ube2d3 Nfkbia Atm Rela Erc1 Btrc Chuk Cyld Xpo1 Malt1 Bcl10 Tnfrsf1a Ran Ikbkb Traf6 Birc2 Tnf Prkca Ikbkg Nfkb1 Ripk2 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Efna5 Fyn TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Map3k8 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Lcp2 Cd80 Prkcq Cd8b Kras Cd8a B2m Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Orai1 Lck Stim1 Akt1 Lat Rassf5 Shc1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Egfr Xrcc5 Atm Terf1 Smg6 Ywhae Tinf2 Max Parp2 Pot1 Acd Egf Znfx1 Terf2ip Hnrnpc Sp1 Pinx1 Sap18 Ccnd1 Sp3 Rbbp7 Esr1 Smad3 Irf1 Cdkn1b Wt1 Ube3a Abl1 Nfkb1 Mxd1 Blm Hus1 Mapk1 Mapk3 Jun Rad1 Fos Il2 Mtor Ifng Rps6kb1 Tgfb1 Mre11 Hsp90aa1 Hdac2 Nbn Nr2f2 Myc Tert Hdac1 Terf2 Akt1 Rad50 E2f1 Xrcc6 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Raf1 Ccna2 Ccnd2 Myod1 Mitf Cebpb Ubtf E2f3 Smarca4 Smarcb1 Tgfb2 Suv39h1 Gsc Brd2 Pax3 Ccnd1 Aatf Rbp2 Bglap Atf7 Runx2 Ckm Mapk9 Taf1 Crebbp Mef2c Mapk11 Rb1 Cdk4 Cdk2 Hdac3 Cdkn1a Met Cdkn1b Pparg Sirt1 Abl1 Ccnd3 Elf1 Spi1 Mdm2 Tbp Ppp2ca Jun Cdkn2a Skp2 Csf2 Mapk14 Atf2 Ccne1 Cebpa Sftpd Ctbp1 Hdac1 Cbx4 E2f1 Cdk6 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Smad2 Map3k1 Smad3 Smad4 Tgfbrap1 Ube2i Pias4 Mapk1 Kpna2 Mapk3 Kpnb1 Ctdsp1 Ppm1a Nup153 Ctdspl HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Id2 Serpine1 Tf Tfrc Vegfa Ncoa2 Ncoa1 Sp1 Arnt Hif1a Plin2 Adm Cp Crebbp Pfkfb3 Furin Nt5e Smad3 Pgm1 Fech Smad4 Pkm Aldoa Cxcr4 Abcb1a Pfkl Rora Hk2 Bhlhe41 Hdac7 Igfbp1 Npm1 Gck Nos2 Gata2 Itgb2 Edn1 Mcl1 Cops5 Ets1 Cxcl12 Bnip3 Jun Epo Bhlhe40 Tff3 Egln3 Fos Cited2 Ndrg1 Pgk1 Slc2a1 Abcg2 Hnf4a Hmox1 Eno1 Tert Lep Akt1 Creb1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Arhgef2 Fyn Pik3r1 Rap1a Vldlr Map1b Mapk8 Lrp8 Lrpap1 Pafah1b1 Dab1 Map2k7 Grin2b Cdk5r1 Gsk3b Reln Nck2 Cbl Crkl Cdk5 Grin2a Mapk8ip1 Map3k11 Itga3 Akt1 Itgb1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Fadd Map3k1 Chuk Pik3r1 Dap3 Smpd1 Ikbkb Mapk8 Mapk1 Ikbkg Traf2 Mapk3 Map2k4 Cflar Pik3cb Casp8 Ripk1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Crh Mapk8 Mapk11 Mapk14 Mapk9 Gnal Gnb1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Itga1 Egfr Src Atr Stat5a Stat3 Stat1 Pdgfrb Pik3r1 Stat6 Vegfa Pdgfb Gab1 Jak3 Egf Jak1 Pias1 Grb2 Sos1 Pik3cb Crebbp Ins2 Hgf Eif2ak2 Stat5b Ptpn2 Csf1 Insr Ptpn1 Csf1r Met Lman1 Kpna2 Kpnb1 Itgb1 Rab4a Shc1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Tab2 Mapk1 Gsk3b Map3k7 Ppm1a Ctdspl Bmp4 Smad4 Zfyve16 Ppp1ca Bmp7 Smad7 Ppp1r15a Bmpr2 Smad1 Bambi Grem1 Ahsg Sostdc1 Smad9 Rgma Hjv Chrd Fst Smurf1 Smad5 Nog Ctdsp1 Bmpr1a Xiap Bmp6 Bmp2 Smad6 Chrdl1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2rl2 Rock2 Gna11 Gnb1 F2 Gna15 Rock1 Gna14 Gna13 Gnaq Rhoa Myl2 Plcb2 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Prkaca Ctnnb1 Gli1 Kif7 Med6 Gli2 Grk2 Ywhae Ptch1 Sap18 Dyrk1a Sufu Boc Arrb2 Kif27 Med23 Med12 Med1 Ccnb1 Dhh Hhip Ihh Stk36 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ar Hdac1 Akt1 Hspb1 Pik3r1 Ptk2 Creb1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Mapk1 Irf2bp1 Ets1 Dynlrb1 Kpnb1 Mapk3 Ube2i Myc Tp53 Skp1 Pdk1 Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d2 Ube2d1 Nup153 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Junb Smad6 Daxx Hnf4a Ing2 Xpo1 Pdpk1 Ctcf Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Runx3 Runx1 Cd44 Runx2 Rb1 Tgfbr3 Prkar2a Trim33 Map2k3 Mef2c Brca1 Zfyve9 Cdkn1a Tgfbr2 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Rps6kb1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Enah Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Jak3 Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Bdh1 Ldhb Tuba4a Zdhhc17 Golga5 Ctla4 Cd3g Actr10 Cd3d Dusp3 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Mpzl1 Map2k1 Hnrnph3 Nedd9 Stat1 Dbnl Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Sdcbp Cd86 Cd84 Sh2d2a Cd82 Snrnp70 Cd80 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Hgs Stk39 Flnb Anxa2 Raf1 Inpp5d Shc1 Stk4 Acly Ripk2 Elmo1 Prp4k Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Adam9 Dnm2 Epha3 Pkm Lck Evl Lcp2 Sos1 Ywhaz Lpxn Atp1a1 Src Atp1a3 Ptpn6 Trim25 Ptpn3 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Stat1 Rps6kb1 Mapk8 Src Gsk3b Nfkbia Grb2 Ikbkb Ncoa1 Khdrbs1 Shc1 Chuk Runx2 Crp Jak3 Erbb2 Irs1 Pde3a Eif4ebp1 Socs7 Prkaa1 Prkaa2 Gnaq Slc2a4 Esr1 Fyn Jak1 Nos3 Rps6 Cfl2 Egfr Akt1 Eif4e Plcg1 Gsk3a Cdk5 Plcg2 Ptk2 Lep Limk1 Prkce Rps6ka2 Mapk1 Acacb Igf1r KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Ptpru Gys1 Csf2rb Stat1 Jak2 Sh3kbp1 Mapk8 Mad2l1 Fgr Hck Prkcb Rps6ka1 Kit Gsk3b Tnfrsf10b Prkca Spred1 Ezr Spred2 Crk Grb7 Mtor Epor Mapk12 Yes1 Rela Kitlg Rdx Msn Stat5a Stat5b Fes Cdk2 Raf1 Hras Inpp5d Crkl Akt1 Cblb Pik3r1 Atf2 Wipf1 Mapk1 Rasa1 Sos1 Rps6kb1 Src Grap Ptpn11 Mapk14 Tec Cltc Jak3 Jun Eif4ebp1 Fyn Rps6 Mitf Socs5 Socs4 Matk Socs6 BCR%NETPATH%BCR BCR Nedd9 Stat1 Foxo3 Hck Fos Prkcb Rps6ka1 Gsk3b Crk Pik3r2 Rela Dok1 Bcar1 Cdk2 Cd72 Stap1 Shc1 Elk1 Sla2 Ctnnb1 Chst15 Bank1 Rb1 Nfatc3 Cd22 Malt1 Cycs Plekha1 Hcls1 Prkcq Gtf2i Lat2 Rasgrp3 Prkd1 Blnk Btk Creb1 Pip4k2b Crkl Pip4k2c Itpr1 Zap70 Pip4k2a Akt1 Cd79b Plcg1 Ptpn18 Ccl4 Pik3cg Ptk2 Atf2 Casp7 Mapkapk2 Nck1 Prkcd Casp9 Mapk1 Nfatc2 Sh2b2 Ifitm1 Fcgr2b Cdk7 Bcl6 Btla Rasa1 Bax Lck Stat3 Pip5k1c Hnrnpk Sos1 Pip5k1b Rps6kb1 Itpr2 Bcl10 Ptpn6 Lyn Mapk14 Grb2 Ikbkb Itk Sh3bp2 Tec Chuk Jun Eif4ebp1 Vav1 Fyn Rps6 Map4k1 Gsk3a Junb Pdpk1 TNFALPHA%NETPATH%TNFALPHA TNFalpha Ccnt1 Cyba Diablo Stat1 Rel Tab2 Mapk8 Traf7 Traf4 Mcm7 Map3k8 Pfdn2 Traf6 Faf1 Birc3 Birc2 Ikbkg Csnk2a1 Tnfrsf8 Ywhah Ywhag Mark2 Psmd12 Hsp90ab1 Tnfrsf1b Akt2 Hdac2 Smarcb1 Dok1 Ywhab Psmd13 Alpl Rasal2 Akap8 Psmb5 Rpl8l1 Ppp6c Gab1 Bcl2l1 Rack1 Fkbp5 Rps6ka5 Smarca4 Fadd Mcm5 Ywhae Smpd3 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Creb1 Map2k5 Itch Hdac1 Zfand5 Akt1 Cflar Hspb1 Bid Ddx3x Trpc4ap Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Mapk1 Casp3 Romo1 Elp1 Psmd1 Casp2 Mapk3 Trim32 Ube2i Spag9 Usp11 Glb1 Skp1 Smarcc2 Pdk1 Sos1 Prc1 Ywhaz Smarcc1 Rnf25 Pkn1 Src Lrpprc Map3k11 Ube2d3 Mtif2 Ube2d2 Btrc Ptpn11 Mapk14 Trap1 Irs1 Jun Cav1 Egfr Cul1 Junb Foxo1 Prkca Stat5a Map2k6 Rb1 Gtf2i Casp7 Mapkapk2 Bax Rpl4 Mapk9 Nkiras1 Brinp1 Nr2c2 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tnf Hsp90aa1 Fbl Ppp1r12a Nfkbia Rpl30 Crebbp Unc5cl Tbk1 Dpf2 Tax1bp1 Grb2 Kcnq1 Polr1b Polr1c Txnip Polr1a Usp2 Xiap Polr1e Fbxw11 Tank Nfkb1 Map3k3 Actl6a Map3k2 Rxra Smarce1 Polr2sl1 Tifa Flna Cdc37 Rffl Inpp5e Rasa3 Nfkbiz Papola Txn Glg1 Bag4 Ripk3 Cradd G3bp2 Dcaf7 Pak1 Cops3 Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Kpna2 Cdk9 Zbtb17 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Fos Prkca Ywhah Pik3r2 Mtor Yes1 Ywhab Shc1 Gab1 Ywhae Ar Akt1 Pik3r1 Pik3cg Ptk2 Prkcd Mapk1 Casp3 Mapk3 Ywhaz Src Clca1 Irs2 Rpsa Rhoa Rac1 Plec Dsp Lama5 Cd151 Itgb4 Lama3 Mst1r Ptpn11 Mylk3 Met Mapk14 Grb2 Pik3r3 Col17a1 Itga6 Ntn1 Ephb2 Lamb2 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Erbb2 Rtkn Irs1 Tp73 Bad Jun Smad2 Eif4ebp1 Smad3 Eif6 Lamc1 Vim Fyn Egfr Eif4e Pak1 WNT%NETPATH%WNT Wnt Csnk1a1 Nlk Lrp5 Gpc3 Dvl3 Mapk8 Wnt2 Wnt1 Tcf7l2 Prkcb Wnt3 Fzd1 Jup Fzd5 Prkca Fzd4 Fzd6 Kremen1 Fzd9 Smad1 Pin1 Mark2 Tcf4 Yes1 Ywhab Prkaca Arrb2 Akt1 Prkcd Nfatc2 Pip5k1b Rhoa Rac1 Jun Ccnd1 Map3k7 Ctbp1 Wnt5a Cdh1 Pi4k2a Ppp1ca Sfrp2 Ppp2ca Sfrp1 Daam1 Cdk6 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Lrp1 Arhgef4 IL6%NETPATH%IL6 IL6 Foxo4 Nlk Stat1 Foxo3 Mapk8 Foxo1 Fgr Hck Fos Gsk3b Pik3r2 Map2k2 Socs3 Map3k4 Pias3 Cd40 Sgk1 Il6st Stat5a Map2k6 Il6 Stat5b Il6r Bmx Ncoa1 Map2k4 Shc1 Gab1 Rb1 Btk Ar Hdac1 Akt1 Plcg1 Hspb1 Pik3r1 Prkcd Mapk1 Mapk3 Stat3 Rps6kb1 Lyn Erbb3 Cbl Rac1 Hsp90aa1 Crebbp Ptpn11 Mapk14 Grb2 Ptk2b Nfkb1 Erbb2 Bad Jun Eif4ebp1 Gab2 Map3k7 Vav1 Fyn Jak1 Eif4e Daxx Cdk9 Map2k1 TSH%NETPATH%TSH TSH Gna13 Tshr Hspa5 Canx Gnai2 Gnai1 Atp1a1 Map2k3 Calr Scrib Gnai3 Gnaq Creb1 Lep Ikbkb Map2k6 Igf1r Raf1 Gna12 Gna11 Mapk3 Gnao1 EGFR1%NETPATH%EGFR1 EGFR1 Map2k2 Ywhab Gab1 Rps6ka5 Dyrk1a Creb1 Itch Hdac1 Pik3r1 Ptk2 Mapk1 Myc Tp53 Irs2 Rhoa Rac1 Plec Dsp Jund Itgb4 Met Pik3r3 Dab2 Col17a1 Ephb2 Sp1 Pik3cb Pik3cd Bad Jun Smad2 Smad3 Cav1 Vim Ctbp1 Cdh1 Stk11 Prkcg Arhgef4 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Jup Gsk3b Crk Pik3r2 Socs3 Map3k4 Pias3 Ap2b1 Map2k3 Scrib App Spart Atf1 Myl12b Pard3 Il17rd Prkd1 Mprip Nedd4 Eno1 Crkl Nectin1 Rps10 Elk4 Plcg1 Gja1 Cblb Tfg Plcg2 Tns4 Scamp3 Tns2 Prkcd Tns1 Itsn2 Ralb Krt8 Otud6b Vasp Cblc Arhgef7 Araf Krt7 Frs2 Frs3 Phlpp1 Actb Actr2 Rps6kb1 Actr3 Pttg1ip Arhgap5 Prkci Arap1 Zdhhc5 Tln1 Lyn Rin1 Pfn1 S100a10 Snca Tfrc Arhgef5 Pik3c2b Hnrnpr Sdc4 Sdc3 Insr Pitpna Kirrel1 Stam Flot1 Atp5f1c Errfi1 Usp6nl Myo6 Slc5a5 Snx5 Tollip Smu1 Dyrk1b Etl4 Cltc Sdc1 Antxr1 Nfkb1 Hip1 Arf4 Braf Adam17 Ptprr Clta Dcbld2 Ptprf Git1 Vav1 Laptm4a Vav2 Cdv3 Plekha6 Cyld Anks1a Mink1 Rplp0 Actn1 Snx33 Actn4 Tkt Baiap2l1 Pak1 Plscr1 Gprc5a Caskin2 Rbck1 Htt Aldoa Git2 Map2k7 Appl2 Stx4 Mpzl1 Rps2 Map2k1 Limd1 Cstb Nedd9 Inppl1 Krt18 Pygb Gsn Mapk8 Pdzd11 Krt17 Ap2s1 Mcf2 Racgap1 Eps15l1 Esyt1 Sdcbp Eppk1 Cttn Axl Ctnnd1 Ensa Stat2 Pkn2 Frk Hipk2 Rela Tjp2 Map3k14 Dok1 Hipk3 Eef1a2 Grb14 Flnb Rictor Grb10 Raf1 Stip1 Cdh2 Plekhn1 Cavin1 Cavin2 Tom1 Cc2d1a Prp4k Cfl1 Prkx Magi1 Hat1 Ap2a1 Pkp2 Ptpra Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Cdk1 Vcl Cysrt1 Stambp Pld1 Map4k5 Lpp Ddx3x Rab5a Pld2 Acp1 Ppp1r14b Itga3 Nck1 Pdgfrb Elmo2 Abl2 Slc38a2 Adam9 Dynll1 Tom1l2 Efnb2 Pkm Ptpre Lck Cav2 Tnk2 Ripk1 Sirpa Ywhaz Ralgds Dlg3 Atp1a1 Alb Bcl2 Crim1 Ptpn6 Ddx6 Pdlim1 S100a11l1 Sh3bgrl Cebpb Afap1l2 Rbm3 Tgif1 Sfpq Nck2 Dapp1 Asap1 Slc12a7 Mt-co2 Ptpn12 Baiap2 Mapk14 Sh3gl3 Arhgap35 Lsr Epha1 Ptk2b Epha2 Epn2 Epn1 Khdrbs1 Dyrk4 Epha4 Rps6ka3 Itgb1 Epn3 Erbb2 Dyrk3 Usp31 Elf3 Eif4ebp1 Klf11 Aplp2 Prkaa1 Dsg2 Prkaa2 Ctnnal1 Cd59b Tnip1 Wbp2 Fyn Jak1 Mvp Trim29 Nos3 Eif4g1 Dock1 Egfr Ephb1 Cebpa Gsk3a Ephb3 Cdk5 Phldb2 Ptpn1 Slitrk6 Rgs16 Rps6ka2 Csk Kras Mta2 Arhgap32 Snrpd2 Egf Tagln2 Spry2 Rbbp7 Spry1 Pten Jak2 Reps2 Sh3kbp1 Ralbp1 Bcar3 Spry4 Pebp1 Ptpn23 Rps6ka1 Slc25a5 Kit Hspe1 Arhgap42 Prkca Zpr1 Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Ptpn18 Pik3cg Casp9 Mapk9 Erbb3 Rpl30 Map3k3 ID%NETPATH%ID ID Rb1 Smad3 Tcf7l2 Rbl2 Psmd4 Fhl2 Rbl1 Id3 Atf3 Map2k2 Hes1 Tcf3 Elk4 Myf5 Mapk1 Cdk2 Raf1 Mapk3 Elk1 Map2k1 IL9%NETPATH%IL9 IL9 Kat5 Stat6 Il9r Stat5a Stat5b Mapk1 Mapk3 IL3%NETPATH%IL3 IL3 Csf2rb Ywhaz Foxo1 Prkcb Ptpn6 Lyn Gsk3b Prkca Crk Pik3r2 Socs3 Socs2 Ywhab Dok1 Bcl2l11 Kcnip3 Rara Fes Slc2a1 Gata2 Hras Inpp5d Shc1 Gab1 Bcl2l1 Prkaca Nfkb1 Rack1 Pik3cd Bad Ptprc Rxra Gab2 Atf1 Creb1 Crkl Ppp2ca Gsk3a Pik3r1 Ptk2 Mapk1 Map2k1 IL5%NETPATH%IL5 IL5 Stat3 Unc119 Stat1 Foxo3 Sos1 Ywhaz Hck Rps6ka1 Lyn Gsk3b Cbl Sdcbp Map2k2 Nfkbia Ptpn11 Mapk14 Grb2 Stat5a Stat5b Ptk2b Raf1 Hras Alox5 Shc1 Pla2g4a Elk1 Il5 Sox4 Ctnnb1 Nfkb1 Rack1 Il5ra Jun Syk Hcls1 Jak1 Crkl Gsk3a Pik3cg Atf2 Prkcd Dnm2 Bax IL4%NETPATH%IL4 IL4 Stat3 Jak2 Rps6kb1 Mapk8 Ptpn6 Irs2 Cbl Cebpb Nfkbia Crebbp Stam Ptpn11 Cd40 Mapk14 Ikbkb Inpp5d Shc1 Elk1 Chuk Nfkb1 Mapk11 Spi1 Pik3cd Il13 Il4 Bad Grk3 Cxcr4 Syk Il13ra1 Snd1 Il2rg Jak1 Cebpa Akt1 Plcg2 Ptk2 Atf2 Prkcd Mapk1 Ets1 Mapk3 Rasa1 IL-7%NETPATH%IL-7 IL-7 Stat3 Stat1 Jak3 Foxo3 Bad Irs1 Foxo1 Il2rg Il7 Irs2 Gsk3b Fyn Map2k2 Akt1 Gsk3a Cblb Pik3r1 Stam Stat5a Mapk1 Stat5b Shc1 Mapk3 Map2k1 NOTCH%NETPATH%NOTCH Notch Stat3 Skp1 Jak2 Src Rbx1 Gsk3b Smad1 Hes1 Tcf3 Hdac2 Rela Nfkb1 Smad3 App Ncstn Aph1b Fhl1 Dll3 Dll4 Maml1 Ring1 Maml2 Akt1 Mfng Furin Pik3r1 Ccn3 Skp2 Jag2 Cul1 Hes6 Mapk1 Maml3 Cirsr Yy1 Psenen Lef1 Notch2 Mapk3 Lfng Psen2 IL2%NETPATH%IL2 IL2 Foxo3 Mapk8 Crk Pik3r2 Mtor Map2k2 Socs3 Rela Sgk1 Stat5a Stat5b Cdk2 Raf1 Shc1 Elk1 Il2rg Creb1 Crkl Akt1 Pik3r1 Pik3cg Atf2 Ccne1 Mapk1 Stam2 Ets1 Mapk3 Il15 Lck Stat4 Il2ra Ybx1 Sos1 Ets2 Plcb1 Tert Nr3c1 Itm2b Bcl2 Ptpn6 Eif3b Il2 Lyn Irs2 Prkcz Cbl Nmi Vil1 Mknk1 Hsp90aa1 Stam Ptpn11 Mapk14 Grb2 Pik3r3 Ptk2b Nfkb1 Pik3cb Jak3 Pik3cd Irs1 Jun Eif4ebp1 Gab2 Vav1 Fyn Jak1 Rps6 Eif4e Map2k1 TSLP%NETPATH%TSLP TSLP Stat3 Stat4 Nfkb1 Stat1 Mapk8 Mapk9 Nfkb2 Nfkbia Eif4e Akt1 Stat6 Rela Mapk14 Stat5a Mapk1 Stat5b Mapk3 Map2k1 RANKL%NETPATH%RANKL RANKL Nfkb1 Spi1 Rel Tab2 Mapk8 Traf6 Map3k7 Nfkb2 Traf3 Tnfsf11 Atp6v1e1 Sqstm1 Tnfrsf11b Ptk2 Trem2 Traf2 Mapk14 Mitf Chuk IL1%NETPATH%IL1 IL1 Rel Tab2 Mapk8 Mapk9 Traf6 Pik3r2 Nfkbia Rela Peli1 Mapk14 Dok1 Map3k14 Ube2v1 Ikbkb Map2k6 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Pla2g4a Ppp6c Myd88 Sod1 Chuk Il1a Nfkb1 Fbxw5 Rb1 Il1b Peli2 Map3k2 Il1r2 Jun Il1r1 Map2k3 Il1rn Akt1 Pik3r1 Atf2 Mapk1 Elp1 Mapk3 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Tkt Hk2 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Mtr Mthfd2 Dhfr Mthfd1l Tyms FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Gale Galt Aldob Aldoc Aldoa Khk Hk2 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Atf1 Srf Traf6 Map3k7 Elk1 Mef2d Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Cryab Mapk3 Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Prkce Sphk1 Prkca Pik3r1 Raf1 Pik3r2 Lpxn Arhgap8 Pik3r3 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Map2k1 Tgfb1i1 Hras INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Il20ra Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il4r Mapk15 Il12rb2 Il11ra1 Srf Spic Il1a Stat5a Elk1 Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Cdkn1b Mapkapk2 Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 Pik3cb Nos3 Il10 Ikbkb Spi1 Il15 Irs1 Cxcr1 Stat6 Cxcr2 Stat4 Il13 Il2ra Il18 Irs2 Sla2 Mapk6 Elk4 Pdpk1 Myc Akt3 Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il23a FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Gnb1 Chrna4 Flna Gnai1 Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Chrnb3 Kcnk3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Pmvk Ggps1 Hmgcr Mvd Fdft1 Lss Sqle Fdps Hmgcs1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Nras Pik3r1 Pik3r2 Pik3r3 Ccne1 Pik3cg Ccng1 Pik3cb Ctnnb1 Pik3cd Kras Tp53 Tp73 Pik3c2b Ppp2cb Pik3c2a Mapk12 Rb1 Cdkn1a Ppp2ca Mapk13 Pten Mapk14 Pik3c2g Rbl1 Hras Siah1 Cdk2 Pik3r5 Atm Atr Tp63 Mapk11 Pdpk1 Akt3 Pik3c3 Akt2 Akt1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcg1 Plce1 Gnb1 Gnb2 Prkcq Gnb4 Plcg2 Gnb3 Prkcg Gnb5 Prkch Itpr3 Prkci Itpr2 Itpr1 Prkcb Prkcd Prkce Prkca Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Itpr1 Grin2a Prkcb Prkar1b Prkx Prkacb Grina Grm1 Plcb4 Grm5 Grik5 Gna11 Grik1 Grin1 Grin2d Grin2c Grin2b Prkaca Gnaq OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Prkx Prkacb Gnao1 Adcy7 Prkar2a Prkar2b Htr1d Htr1f Gnai2 Htr1b Htr1a Gng11 Gnai3 Gng10 Kcnk3 Adcy2 Gng3 Gng5 Prkaca Gng7 Kcnk9 Gng8 Gngt2 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcg1 Plce1 Gnb1 Gnb2 Prkcq Gnb4 Plcg2 Gnb3 Prkcg Gnb5 Prkch Prkci Prkcb Prkcd Prkce Prkca Prkcz Oxtr Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gnb1 Htr4 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Gng10 Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Prkar1b Prkacb Gnao1 Adcy7 Prkar2a Prkar2b Gng11 Gnai3 Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy8 Adcy5 Adcy6 Cacna1g Kcnj3 Adcy2 Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Atg7 Sae1 Ube2l3 Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2d2 Uba3 Ube2d1 Ube2e2 Ube2g2 Ube2g1 Ube2l6 Ube2a ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway Fzd2 Jup Gsk3b Fzd5 Trim3 Fzd4 Fzd6 Fzd9 Fzd8 App Erbb4 Apbb3 Nectin1 Trpc6 Afdn Trpc5 Trpc7 Kat5 Wnt5a Cdh1 Trpc1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Bace2 Bace1 Wnt10b Acta1 Actb Actr2 Ern1 Psenen Ctnnb1 Notch1 Notch2 Notch3 Psen1 Psen2 Wnt8a Fstl1 Lef1 Wnt11 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Cd44 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Aldh1a2 Maob Aldh1a1 Aldh3a2 Aldh1a3 Aldh2 Aldh3a1 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Tp63 Tp53 Tp73 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Itpr3 Itpr2 Sos1 Itpr1 Mapk9 Mapk8 Chuk Nfkbil1 Mapk12 Cd22 Vav3 Mapk13 Syk Mapk14 Vav1 Vav2 Map3k3 Map3k2 Blnk Btk Cd79b Ptpn6 Ppp3ca Lyn Ptprc Jun Mapk11 Ppp3cb Nfkbia Mapk1 Grb2 Mapk10 Mapk3 Rac2 Rac1 Araf Plcg2 Nras Prkcb Prkcd Raf1 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Fos P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Ppp2cb Ppp2ca Tp63 Eif4ebp1 Tsc2 Tsc1 Igbp1 Akt3 Prkaa1 Akt2 Prkab2 Rps6kb1 Prkaa2 Akt1 Prkab1 Tp53 Prkag1 Tp73 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Lpl Pla1a Plcb2 Plcb1 Plcb3 Dagla MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Rorc Mtor Arnt Txn Txn2 Crebbp Egln2 Egln3 Vhl Hif1a Akt3 Akt2 Akt1 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Prkar1b Crebbp Gtf2a1l Polr2c Prkar2a Taf1c Prkar2b Taf9 Creb3l3 Creb3l4 Polr2h Creb3l1 Polr2e Creb3l2 Ttf2 Polr2f Taf9b Taf11 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Tbp Brf2 Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Polr2sl1 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf2 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Gng10 Gnao1 Adcy2 Adcy7 Gng3 Gng5 Pomc Oprd1 Gng7 Gnai2 Gng8 Gngt2 Gnai3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Ednrb Ednra Itpr3 Adcy3 Itpr2 Edn1 Itpr1 Edn2 Edn3 Prkar1b Adcy10 Prkacb Gucy1b1 Prkg2 Gucy1a1 Gucy1a2 Adcy7 Prkar2a Prkar2b Gnal Adcy4 Adcy8 Adcy5 Adcy6 Mapk1 Pla2g4a Adcy2 Prkaca Mapk3 Akt1 Araf Prkcq Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Raf1 Prkcz Nos3 Map2k2 Map2k1 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Akt3 Akt2 Gnaq HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Gch1 Dhfr Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcg1 Plce1 Gnb1 Gnb2 Prkcq Gnb4 Plcg2 Gnb3 Prkcg Gnb5 Prkch Prkci Prkcb Prkcd Prkce Prkca Htr2a Htr2c Htr2b Prkcz Gng11 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Sos1 Shc1 Mapk9 Mapk8 Map3k3 Map3k2 Mapk10 Flna Col14a1 Itgbl1 Crkl Arfgap1 Col1a2 Col5a2 Col5a3 Col5a1 Dmbt1 Col9a2 Col9a1 Map3k4 Lama5 Arpc1b Arpc1a Lama1 Lama3 Mapk13 Lama4 Flnb Tln1 Vcl Vasp Map2k4 Col17a1 Col13a1 Fn1 Itga7 Itga8 Arl1 Itga5 Itga6 Itga9 Itga3 Elmo2 Itga1 Itga2 Elmo1 Braf Itga10 Col4a3 Arpc3 Pik3c3 Col4a1 Mapk3 Cav1 Arpc2 Rac2 Col4a2 Col4a5 Rac1 Col8a1 Parvb Araf Arpc5 Parva Rap2b Col16a1 Arf1 Col12a1 Nras Itgax Ilk Itgav Rnd2 Rnd3 Rhoa Rnd1 Rhob Itgam Pik3r1 Raf1 Asap1 Arhgap10 Pik3r2 Itgal Rap1a Col3a1 Pik3r3 Rap1b Pxn Itgad Itgb8 Actb Itgb6 Pik3cg Itgb7 Itgb1 Pik3cb Itga2b Pik3cd Itgb4 Rras Itgb2 Pik3c2b Actn1 Pik3c2a Actn4 Ptk2 Crk Arf6 Map2k2 Arhgap26 Map2k1 Col11a1 Col11a2 Hras Src Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a2 Ptk2b Mapk6 Lims2 Map2k3 Lamc1 Actg1 Actbl2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Shc3 Rasa2 Rps6ka3 Rasa1 Gsk3b Pdgfrb Rps6ka6 Pdgfra Rps6ka1 Pdgfrl Rps6ka2 Pdgfa Pdgfb Sos1 Grap Shc1 Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Mapk15 Elf1 Elf2 Gsk3a Elf3 Stat5a Elf4 Stat5b Elf5 Ophn1 Stat3 Usf2 Stat2 Grap2 Stat1 Mapk8 Elp1 Chuk Rerg Nin Vav3 Pkn2 Ninl Vav1 Arhgap42 Vav2 Map3k2 Jun Grb2 Mapk10 Rps6kb1 Pik3r5 Itpr3 Itpr2 Itpr1 Srf Elk1 Map3k4 Mapkapk2 Rps6ka5 Mknk2 Mknk1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Pik3r1 Raf1 Arhgap10 Pik3r2 Arhgap8 Pik3r3 Shc2 Pik3cg Pik3cb Pik3cd Map2k2 Arhgap26 Map2k1 Hras Ikbkb Stat6 Stat4 Mapk6 Elk4 Pdpk1 Srgap1 Myc Ehf Srgap3 Akt2 Rab11b Jak3 Arhgap5 Arhgap4 Erf Erg Fos Arhgap9 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrnb4 Chrna10 Myh2 Myh3 Chrnb3 Myh4 Myh7 Chrnb2 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Chrna3 Plekhh3 Myh10 Chrna6 Myh7b Chrna5 Myo6 Myo18b Chrna4 Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Myo15a Myo16 Myo19 Acta1 Actb Actg1 Actg2 Actbl2 Actc1 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak3 Stat5a Stat5b Stat6 Stat3 Stat4 Jak2 Stat1 Jak1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psph Psat1 Phgdh AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Plcg1 Plcg2 Pik3r1 Ntn1 Pik3r2 Ntn3 Nfatc4 Nfatc3 Pik3r3 Nfatc2 Ablim1 Dcc Ntng1 Pik3cg Unc5b Unc5d Pik3cb Unc5c Pik3cd Pik3c2b Pik3c2a Vasp Pik3r5 Rac2 Rac1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a16 Slc18a1 Slc6a2 Slc6a3 Slc18a2 Slc6a19 Slc6a18 Slc6a15 Slc6a20a NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt2b7 Fmo3 Cyp2a3 Ugt1a2 Ugt1a3 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Tubb5 Tubb6 Tubb3 Mylk Limk1 Arpc4 Rock2 Tubb4b Rock1 Arpc1b Arpc1a Myo3b Myh2 Myh3 Myh4 Myh7 Arpc3 Myh11 Rac2 Arpc2 Rac1 Myh10 Myh7b Arpc5 Acta1 Actb Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Actg1 Pak6 Actg2 Stmn4 Pak3 Pak2 Pak5 Actbl2 Pak4 Actc1 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rps6ka3 Rasa1 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Ins2 Insr Igf2r Igf2 Igf1 Insrr Igf1r Raf1 Elk1 Map2k2 Map2k1 Rps6ka5 Irs1 Irs2 Mapk1 Map2k3 Mapk3 Rps6kb1 Fos INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Ifng Ifngr1 Jak2 Stat1 Jak1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Uprt Upp2 Nme3 Nme2 Uck1 Uck2 Uckl1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Gnb2 Gnb4 Gnb3 Gnb5 Grin2a Prkar1b Prkx Adcy10 Prkacb Grm1 Grm5 Grik5 Grik1 Grin1 Grin2d Grin2c Grin2b Prkar2a Prkar2b Gnai2 Cacna1e Grm4 Gnai3 Grm7 Grm6 Grm8 Cacna1a Vamp8 Cacna1b Vti1a Vamp1 Vamp3 Gria4 Vamp2 Gria3 Gria2 Slc1a1 Slc1a3 Slc1a2 Slc17a7 Slc1a7 Slc1a6 Stx1b Cacnb1 Snap29 Stx1a Snap25 Snap23 Grik2 Grik4 Grik3 Prkaca Gnb1 Gnai1 Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Igf2r Atf1 Mapk9 Mapk8 Chuk Map2k4 Jun Nfkbia Mapk1 Mapk10 Atf2 Birc3 Mapk3 Eif2ak2 Birc2 Akt1 Tnf Tnfrsf1b Madd Bcl2l11 Tnfrsf1a Prkcq Tradd Nfkb2 Prkcg Nfkb1 Prkch Traf2 Cycs Bcl2l1 Prkcb Xiap Endog Rela Prkcd Map3k1 Prkce Apaf1 Tnfrsf10b Prkca Lta Fadd Atf7 Ltb Atf6 Atf4 Jdp2 Atf3 Aifm1 Map2k7 Gzmf Pik3cg Map4k3 Atf6b Pik3cb Cradd Pik3cd Bak1 Casp9 Tp53 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Diablo Ikbkb Bax Rel Bcl2 Fas Faslg Daxx Map3k14 Map2k3 Akt3 Akt2 Fos LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Gsk3a Srf Elk1 Stat3 Map2k6 Mapk9 Map3k4 Stat1 Mapk8 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Map2k4 Jun Mapk11 Mapk1 Grb2 Mapk10 Braf Ets1 Pik3c3 Atf2 Mapk3 Rac2 Akt1 Rac1 Araf Nras Rhoa Map3k1 Rhob Raf1 Map2k7 Pik3cg Pik3cb Pik3cd Kras Map2k2 Map2k1 Hras Tiam1 Ralgdsl1 Rala Ralb Exoc2 Pld1 Pld2 Ralgds Map2k3 Pdpk1 Akt3 Pak1 Pak3 Pak2 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Gnb1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Prkca Raf1 Elk1 Gng11 Map2k2 Map2k1 Plcb3 Gng10 Mapk1 Plcb2 Plcb1 Grk3 Grk2 Gng3 Arrb2 Arrb1 Egr1 Mapk3 Gng7 Agtr1 Gnaq Agt Gng8 Gngt2 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Taf9b Taf11 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Chek2 Gadd45b Gadd45a Hdac1 Sfn Cdkn2a Traf2 Mta2 Ccnb1 Gtse1 Cdk1 Sirt1 Cdc25c Crebbp Mdm2 Mdm4 Ccne1 Tp53 Tp73 Cdkn1a Pten Cdk2 Atm Atr Tp63 Pdpk1 Akt3 Akt2 Gadd45g Akt1 Sumo2 Sumo3 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Trh Trhr Stx3 Cga Cacnb3 Cacnb4 Cacnb2 Tshb Cacna1e Cacna1a Vamp8 Cacna1b Vamp1 Vamp3 Vamp2 Cacnb1 Snap29 Snap25 Snap23 Plcg1 Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Pcdhb2 Pcdhb1 Cdh9 Cdh8 Cdh7 Cdh6 Pcdhgb7 Cdh5 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Ctnnb1 Pcdhga2 Ctnnd1 Pcdhga3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Acta1 Actb Actr2 Wnt8a Fstl1 Lef1 Wnt11 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 UNTITLED%PANTHER PATHWAY%P06664 untitled Skil Rela Tgif1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpyd Dpysl2 Cda Dpysl3 Upb1 Nt5e Dpysl5 Abat Aldh6a1 Dpys ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gnb1 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Prkx Prkacb Gng10 Adrb1 Adcy2 Adcy7 Prkar2a Prkar2b Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Gsk3b Pten Ins2 Irs1 Insr Igf2r Igf2 Igf1 Insrr Igf1r Irs2 Foxo1 Mdm2 Tsc2 Pdpk1 Mdm4 Tsc1 Gsk3a Foxo3 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gnb1 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Prkx Prkacb Gng10 Hrh2 Adcy2 Adcy7 Prkar2a Prkar2b Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gnb1 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Gng10 Adrb3 Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Ampd3 Gda Xdh Nt5e METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gnb1 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Gna11 Gng10 Gna14 Gng3 Gng5 Crh Pomc Crhr2 Gng7 Crhr1 Gnaq Gng8 Gngt2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Mapk4 Klc4 Klc3 Prkcq App Klc2 Apba1 Prkcg Apba2 Prkch Apba3 Prkci Pkn1 Prkcb Kat5 Prkcd Prkce Prkca Cacnb2 Bace2 Bace1 Mapk15 Prkcz Psenen Mapk9 Psen1 Mapk8 Psen2 Mapk12 Mapk13 Pkn2 Mapk14 Ncstn Aph1b Cacna1c Mapk11 Cacnb1 Mapk1 Mapk6 Mapk10 Mapk3 Cacna1f Cacna1d Klc1 Adam17 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Shc3 Rasa2 Rasa1 Sos1 Grap Erbb2 Shc1 Erbb3 Mras Rasal2 Egfr Phldb2 Nf1 Rras2 Dab2ip Spry2 Gab1 Spry1 Gab2 Spry4 Pebp1 Stat5a Stat5b Stat3 Map2k6 Stat2 Mapk9 Map3k4 Stat1 Mapk8 Mapk12 Mapk13 Mapk14 Map3k3 Map3k2 Map2k4 Mapk11 Prkd3 Mapk1 Mapk10 Prkd1 Braf Prkd2 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Erbb4 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Shc2 Map2k7 Pik3cg Prkcz Pik3cb Pik3cd Rras Pik3c2b Pik3c2a Map2k2 Map2k1 Hras Pik3r5 Stat6 Stat4 Map2k3 Akt3 Akt2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Mmp9 Serpinb2 Fgb Fga Mmp13 Plau Mmp1 Fgg Plat Plg Serpine1 Serpinf2 PNAT%PANTHER PATHWAY%P05912 PNAT Gnb1 Gnb2 Gnb4 Flna Gnb3 Gnai1 Prkx Prkacb Stx3 Adcy7 Prkar2a Prkar2b Gnai2 Gng11 Gnai3 Epb41l3 Drd1 Slc6a3 Vamp8 Drd5 Ppp1cc Vamp1 Gnaz Vamp3 Vamp2 Epb41l2 Clic6 Ppp1r1b Kcnk3 Snap29 Epb41l1 Slc18a2 Snap25 Adcy2 Snap23 Drd2 Gng3 Drd4 Ppp1ca Prkaca Kcnk9 Gng8 Epb41 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Crebbp Shh Smo Ptch1 Sufu Stk36 Fbxw11 Gli1 Btrc MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Slc5a7 Gnb5 Prkar1b Adcy10 Prkx Prkacb Gnao1 Prkar2a Prkar2b Gnai2 Gng11 Gnai3 Slc18a3 Kcnj3 Slc6a8 Kcnj9 Kcnj6 Gng10 Kcnj5 Chrm2 Chrm4 Gnat2 Gnat1 Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Amdhd2 Gnpda2 Npl Gfpt1 Gfpt2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Map3k7 Mapk9 Mapk8 Mapk12 Mapk13 Mapk14 Jun Mapk11 Mapk1 Mapk10 Bmp10 Atf2 Bmp8a Mapk3 Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf1 Jund Acvr1c Snip1 Lefty1 Tgfb2 Tgfb3 Nras Gdnf Cited1 Acvrl1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Crebbp Gdf3 Gdf6 Bmp7 Bmp6 Bmp5 Gdf7 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Rras Nodal Bmp2 Smad3 Skil Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Hras Inhba Inhbb Acvr2b Junb Inhbc Tgfbr1 Smad5 Tgfbr2 Smad6 Smad7 Gdf11 Inhbe Gdf10 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Proz F2 Tfpi Serpina10 F3 F7 Thbd F8 F9 Pros1 Fgb Fga Plau Fgg Itga2b Plat Plg F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr F10 Vwf F12 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnb1 Gnb2 Gsk3b Gnb4 Gnb3 Gnai1 Gnb5 Nras Sos1 Insr Ptger1 Foxo4 Gngt1 Ywhaz Pik3r1 Pik3r2 Pik3r3 Pik3cb Gnai2 Casp9 Nos3 Gnai3 Pik3r5 Irs1 Gna11 Gna14 Foxo1 Gnat2 Pdpk1 Akt3 Akt2 Rps6kb1 Foxo3 Gnaq Akt1 Gngt2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Gsk3b Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Oprl1 Phka1 Phka2 Adrb2 Adra1b Adra1a Gsk3a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Htr5a Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Grm2 Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Mtnr1b Adcy2 Pygb Drd2 Pygl Drd4 Gpr50 Oprk1 Prkaca Gnb1 Gnai1 Crebbp Creb3l3 Creb3l4 Creb3l1 Creb3l2 Creb5 Gng10 Adrb1 Hrh2 Adrb3 Hrh1 Gng3 Gng5 Oprd1 Gng7 Gng8 Gngt2 Gnb2 Adcy3 Prkar1b Prkacb Grm1 Grm5 Htr2a Htr2c Htr2b Adcy7 Prkar2a Prkar2b Htr1d Htr1f Gnai2 Htr1b Htr1a Grm4 Gnai3 Grm7 Htr4 Grm6 Gnal Grm8 Drd1 Drd5 Adcy4 Adcy8 Adcy5 Adcy6 Kcnj3 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Rap1a Rap1b FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Shc3 Rasa2 Rasa1 Sos1 Grap Shc1 Spry2 Spry1 Spry4 Pebp1 Map2k6 Mapk9 Map3k4 Mapk8 Mapk12 Mapk13 Mapk14 Map3k3 Map3k2 Map2k4 Ptpn6 Mapk11 Mapk1 Mapk10 Pik3c3 Map3k6 Mapk3 Frs2 Rac2 Frs3 Akt1 Fgfr3 Rac1 Fgfr4 Fgfr1 Plcg1 Fgfr2 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Map2k7 Pik3cg Prkcz Pik3cb Pik3cd Pik3c2b Pik3c2a Map2k2 Map2k1 Hras Map2k3 Akt3 Akt2 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Asl Cps1 Ass1 Otc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnb1 Gnb2 Gnb4 Gnb5 Cnga3 Pdc Cnga1 Grk1 Rho Calml3 Rgs9 Gngt1 Cngb1 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng10 Gnat1 Gng3 Gng5 Gng7 Gng8 Gngt2 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Sfn Ywhaz Psma4 Psma3 Psma6 Psma5 Mapk15 Ccne2 Psma2 Ccne1 Psma1 Cask Ywhah Elk1 Ywhag Ywhae Th Mapk9 Ywhab Mapk8 Psmb10 Sncaip Mapk12 Psmb7 Slc6a3 Prkn Mapk14 Psmb1 Gpr37l1 Septin5 Psmb3 Stx7 Septin2 Septin1 Stx12 Gpr37 Ndufv2 Snca Mapk1 Pld2 Mapk10 Mapk3 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Gnb1 Gnb2 Prkcq Gnb4 Gnb3 Slc5a7 Prkcg Gnb5 Prkch Itpr3 Prkci Itpr2 Pkn1 Itpr1 Grin2a Prkcb Prkcd Prkce Prkca Grin1 Grin2d Grin2c Grin2b Prkcz Gng11 Chrm1 Pkn2 Chrm3 Slc18a3 Plcb4 Gna11 Gng10 Gna14 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Pdyn Penk Gng10 Adcy2 Adcy7 Gng3 Gng5 Oprd1 Gng7 Gnai2 Gng8 Gngt2 Gnai3 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 H3f3b Rpa2 Top1 Dna2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Impdh2 Rrm2b Gmps Ak3 Ak2 Ak4 Adss2 Nme1 Atic Nme7 Ppat Nme6 Guk1 Gart Nme3 Nme2 Dscaml1 Adsl Rrm2 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rara Gc F13b Rxra Vdr HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Gngt1 Grm1 Adora2b Grm5 Adora2a Rap1gap Rasgrp3 Oprl1 Rasgrp4 Rasgrp1 Gnao1 Rasgrp2 Arhgef1 Bdkrb2 Bdkrb1 Gpr45 Sstr5 Sstr4 Sstr3 Cacna1e Sstr2 Grm4 Sstr1 Grm7 Oprm1 Grm6 Grm8 Cacna1a Chrm1 Drd1 Cacna1b Chrm3 Drd5 Chrm5 Adora1 Gnrhr Grm2 Clta Cltb Cltc Chrm2 Chrm4 Drd2 Drd4 Oprk1 Gnb1 Prkcq Prkcg Prkch Prkci Prkcb Prkcd Rhoa Prkce Prkca Gng13 Rap1a Rap1b Prkcz Dnajc27 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng5 Oprd1 Gng7 Gnaq Gng8 Gngt2 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Fzd2 Rasa1 Fzd5 Gsk3b Pdgfrb Pdgfra Pdgfa Pdgfb Sos1 Grap Shc1 Nck2 Jak1 Nck1 Stat3 Stat1 Mapk8 Jun Frs2 Frs3 Fgfr1 Ctnnb1 Pak1 Pak3 Pak2 Crkl Grb14 Fgf1 Dok1 Dok3 Axin1 Grb7 Hspb1 Pdgfc Tcf7 Mapkapk3 Efnb1 Jag2 Mapk14 Efnb2 Mapkapk2 Jag1 Pla2g4d Angpt1 Map2k4 Apc2 Epha3 Ephb1 Dll1 Ephb2 Ephb3 Dll3 Dll4 Prr5 Dlk1 Prkd3 Apc Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Cryab Mapk3 Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Wnt5a Map3k1 Prkce Rhoa Sphk1 Prkca Rhob Pik3r1 Wnt5b Raf1 Pik3r2 Lpxn Arhgap8 Pik3r3 Shc2 Wnt10b Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Notch1 Notch2 Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Crk Map2k2 Map2k1 Tgfb1i1 Hras Src Rbpjl Wnt7b Dvl1 Dvl3 F2r Pld1 Wnt7a Pld2 Wnt2 Wnt1 Akt3 Akt2 Tcf7l2 Fzd1 Fos DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Rrm2b Nme1 Nme3 Nme2 Dscaml1 Tyms Rrm2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stx2 Unc13d Vamp1 Stx1b Syt5 Syt3 Stx1a Syt2 Snap25 Syt1 Syt11 Syt12 Syt7 Syt6 Rab3a Stxbp1 Unc13c Unc13b Syt15 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Rps6ka3 Gsk3b Rps6ka1 Sos1 Shc1 Jak2 Stat3 Mapk9 Mapk8 Ppp3ca Lyn Jun Creb1 Nfkbia Grb2 Mapk10 Slc18a2 Eif4ebp1 Prkaca Rps6kb1 Gnb1 Nfatc2 Ctnnb1 Ywhab Foxo1 Pak1 Itpr1 Rock1 Prkacb Plau Srf Traf6 Elk1 Mef2d Map2k6 Hspb1 Mapk14 Eif4e Map2k4 Mef2c Mapk1 Pla2g4a Prkd1 Braf Prkd2 Atf2 Mapk3 Akt1 Rac1 Plcg1 Araf Nr2c2 Prkcq Clu Ier3 Rps6 Prkch Sp1 Sp3 Prkcb Elavl1 Bcl2l1 Akt1s1 Itgav Yes1 Prkcd Snai1 Prkce Tcf4 Rhoa Cdh1 Hbegf Prkca Nos1 Hdac7 Pik3r1 Raf1 Akap1 Cckbr Pparg Gucy2e Arhgef28 Cd38 Pxn Ptgs2 Camk4 Odc1 Map2k5 Itgb1 Ptpn11 Pik3cb Tpcn1 Bad Cck Gast Map3k11 Ptk2 Crk Casp3 Map2k2 Map2k1 Src Bax Bcar1 Bcl2 Irs1 Map3k14 Ptk2b Elk4 Pdpk1 Arrb2 Egr1 Foxo3 Fos GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pklr Eno1 Bpgm Eno2 Pfkl Pkm Pgk1 Pgam2 Tpi1l2 Gpi Pfkm Hk2 Aldoa NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Dll4 Dlk1 Jag2 Jag1 Maml1 Numb Notch1 Cirsr Notch2 Rbpjl Notch3 Dll3 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Abat Gad1 Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Apaf1 Fadd Casp9 Mapk9 Casp8 Mapk8 Casp7 Casp3 Map2k4 Fas Faslg Daxx Faf1 Jun Parp3 Parp2 Parp1 Cflar Mapk10 Lmnb1 Lmnb2 Gsn Casp6 Capg Scin Dffb INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Fpr1 Fpr3 Ccr10 Ccr1 Xcr1 Ccrl2 Ltb4r2 Rhog Sos1 Grap Ccr9 Shc1 Ccr8 Ccr7 Ccr6 Ccr5 Il2 Ccr4 Jak2 Ccr3 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Ccl12 Ccl7 Camk2a Ccl5 Ccl4 Ccl3 Ccl2 Pf4 Prex1 Cx3cl1 Stat3 Nfat5 Ccl22 Ccl20 Chuk Ccl21 Vav1 Myo3b Myh2 Jun Myh3 Myh4 Myh7 Adcy2 Myh11 Prkaca Myh10 Myh7b Gnai1 Nfatc4 Nfatc3 Nfatc2 Cask Kras Plcb4 Plcb3 Gna11 Gng10 Gna14 Mylk2 Plcd1 Plcb2 Mylk3 Plcd4 Plcb1 Gng3 Pak1 Gng5 Plcl1 Pak6 Gng7 Gnaq Pak3 Gng8 Pak2 Pak5 Plcz1 Pak4 Plce1 Mylk Gnb3 Arpc4 Itpr3 Itpr2 Itpr1 Rock1 Prkx Prkacb Ifng Col14a1 Gnao1 Gnai2 Gnai3 Arpc1b Arpc1a Adcy5 Adcy6 Mapk1 Arpc3 Mapk3 Arpc2 Rac2 Akt1 Rac1 Plcg1 Araf Jund Arpc5 Plcg2 Nfkb2 Col12a1 Nras Prkcb Rela Prkce Rhoa Raf1 Itgal Acta1 Actb Pik3cg Itgb7 Prkcz Itgb1 Pik3cb Pik3cd Rras Ikbkb Junb Cxcr1 Cxcr2 Col6a2 Ptk2b Pdpk1 Akt3 Akt2 Actg1 Actg2 Cxcr3 Cxcr4 Cxcr5 Vwf Actbl2 Cxcl10 Actc1 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Prtfdc1 Hprt1 Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Tubb5 Tubb6 Tubb3 Rhog Tubb4b Grin2a Grik5 Grik1 Grin1 Grin2d Grin2c Grin2b Mapk9 Arpc1b Arpc1a Hip1 Bdnf Ift57 Dync1h1 Map2k4 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Cltb Dync1i1 Map3k10 Ap2a2 Ap2a1 Jun Hap1 Hip1r Kalrn Htt Gapdhs Dync1li2 Dync2h1 Grik2 Dync1li1 Grik4 Dnai2 Grik3 Dynll1 Dynll2 Rac2 Capn9 Cyc1 Rac1 Capn5 Capn7 Capn6 Capn1 Arpc5 Capn3 Capn2 Dlg4 Dnah5 Sp1 Dnah8 Cyfip1 Capns1 Capn11 Capn12 Apaf1 Crebbp Acta1 Actb Map2k7 Actr2 Tp53 Tp73 Casp8 Casp3 Tbp Tp63 Tubb2b Tubb2a Actg1 Actg2 Fos Actbl2 Actc1 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pklr Me1 Clybl Pck1 Pkm Cs Acly Pc Pdha2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Map3k8 Tbk1 Ticam2 Irak4 Ecsit Nfkbie Irak1 Traf6 Tollip Map3k7 Tlr10 Elk1 Myd88 Tank Irf3 Mapk9 Tlr7 Mapk8 Tlr6 Chuk Tlr4 Map2k2 Tirap Map2k1 Tlr3 Mapk14 Tlr2 Ikbkb Jun Nfkbia Map2k3 Mapk3 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Fzd2 Fzd5 Hdac1 Fzd4 Fzd6 Fzd9 Fzd8 Pcdhb2 Pcdhb1 Cdh9 Cdh8 Cdh7 Cdh6 Pcdhgb7 Cdh5 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Ppp3ca Pcdha7 Pcdha6 Pcdha8 Pcdha3 Ppp3cb Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Crebbp Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Tle2 Tle1 Ctnna2 Ctnna1 Ppp3cc Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Fbxw11 Btrc Prkcq Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Smad1 Prkcz Smad4 Smad5 Gsk3b Gnb1 Csnk1d Csnk1e Gng13 Nfatc4 Nfatc3 Nfatc2 Ctnnb1 Ppp2cb Ppp2ca Siah1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng5 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Axin1 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Wnt8a Fstl1 Lef1 Wnt11 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Arrb2 Arrb1 Wnt3 Tcf7l2 Fzd1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp Prtfdc1 Hprt1 Aprt Xdh Ada TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Prkar1b Adcy10 Prkx Prkacb Gnao1 Prkar2a Prkar2b Gnai2 Cacna1e Gng11 Gnai3 Cacna1a Vamp8 Cacna1b Vamp1 Vamp3 Vamp2 Grm2 Gng10 Stx1b Cacnb1 Snap29 Gnat2 Stx1a Snap25 Snap23 Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnb1 Avp Oxt Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Pdyn Gng10 Gnao1 Adcy2 Adcy7 Gng3 Gng5 Oprk1 Gng7 Gnai2 Gng8 Gngt2 Gnai3 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Gnb1 Gnb2 Gnb4 Cacna1a Gnb3 Gnai1 Cacna1b Cacna1g Grm1 Grm5 Plcb3 Plcb2 Gnao1 Plcb1 Gng3 Gng5 Cnr1 Gng7 Gng8 Gngt2 Gng11 Gnai3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1b Ubtf Taf8 Psmc3ip Taf1c Tbp Rrn3 Polr1b Tbpl2 Taf1a Tbpl1 Cavin1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gnb1 Gnb2 Gnal Gnb4 Gnb3 Gnb5 Prkx Prkacb Gng10 Adcy2 Adcy7 Prkar2a Adrb2 Prkar2b Gng3 Gng5 Prkaca Gng7 Gng8 Gngt2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gnb1 Gnb2 Gnb4 Gnb3 Gnai1 Gnb5 Prkx Prkacb Gnao1 Adcy7 Prkar2a Prkar2b Gnai2 Gnai3 Oprm1 Gnal Pdyn Penk Gng10 Creb1 Adcy2 Gng3 Gng5 Prkaca Oprd1 Gng7 Gng8 Gngt2 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plce1 Prkcg Itpr1 Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Adra2c Adra2b Plcb2 Plcb1 Adra1b Adra1a LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ren1 Ace Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pc Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 Sdhd Sdhc ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Acss3 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Dusp1 Cd40lg Nfkb1 Chuk Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Itpka Plcb4 Miox Ptpmt1 Inpp4a Ipmk Pikfyve Impa1 Mtor Isyna1 Vac14 Becn1 Inpp1 Sacm1l Pik3cb Pik3r4 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ren1 Ace Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Gaa Agl Pygl Amy1 Ugp2 Pgm1 Ugdh Gpi Gusb Pgm2l1 Gys1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Cyp2b2 Aldh1a1 Gstm2 Aldh3a1 Cyp2c11 Cyp2a3 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Gls2 Glud1 D2hgdh Sdhd Sdhc GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map2k1 Nfkb1 Lck Rasgrp1 Grb2 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Cd3d Map2k7 Calm2 Mapk3 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Nfkbia Rela Map3k1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Akr1c18 Abcg2 Cbr1 Ralbp1 Abcc1 Por Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Dld Hal Gls2 Sds Glud1 Aqp8 Asrgl1 Asns Amt Cps1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1f Cacna1d Map2k1 Mapk1 Nfkb1 Itpr1 Plcb1 Raf1 Prkcb Hras Prkca Mapk3 Cacna1c Nfkbia Rela CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Ins2 Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pik3cd Pip4k2a Plcb1 Pik3r1 Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Odc1 Srm ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ren1 Ace Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Tpi1l2 Gmppa Mpi Pmm1 Sord Uxs1 Akr1b1 Khk Pfkfb1 Gmds Pfkl Fbp1 Aldoa ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Slc28a3 Cmpk1 Rrm2 Slc29a1 Slc28a1 Ctps1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Nqo1 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Pdia2 Atp1a4 Sdf2l1 Atp1a3 Ugt1a6a Fxyd2 Atp2a2 Hyou1 Scn5a Comt Pdia6 Kcnd3 Pdia4 Ppib Kcnj8 Dnajb11 Snta1 Cyp1a2 Kcnj5 Kcnh2 Ugt1a9 Erp29 Kcnj4 Ugt1a5 Chrm2 Kcnk1 Ugt1a1 Kcnq1 Hspa5 Slc8a1 Ephx1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Cyp2e1 Kcnj11 Abcc9 Cacna2d2 Cyp2c11 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Itpa Rrm2 Cad Cant1 Nme6 Dhodh Tyms Tymp Rrm2b Cda Upb1 Gda Dpys Ak3 Ctps1 Cmpk2 Upp2 Dctd Dpyd Uckl1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acaa2 Acat1 Acadl Echs1 Acads Hadh Acss3 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Fmo1 Cyp2d4 Cyp2b2 Fmo3 Cyp3a73 Esr1 Ugt1a9 Ugt1a5 Sult1a1 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Qars1 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcc3 Cdkn1a Tp53 Abcb1a Ralbp1 Abcc1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Aldh1a1 Dnajb11 Erp29 Cyp2a3 Ugt1a1 Hspa5 Cyp2b2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ren1 Ace Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Itpa Rrm2 Cad Cant1 Nme6 Dhodh Tyms Tymp Rrm2b Cda Upb1 Gda Dpys Ak3 Ctps1 Cmpk2 Upp2 Dctd Dpyd Uckl1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Tktl1 Fbp2 H6pd Rpia Prpsap1 Pfkm Gpi Taldo1 Rpe Rbks Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pklr Eno1 G6pc1 Pgam2 Pfkm Gpi Galm Hk2 Tpi1l2 Aldoa FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Tpi1l2 Gmppa Mpi Pmm1 Sord Uxs1 Akr1b1 Khk Pfkfb1 Gmds Pfkl Fbp1 Aldoa AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ren1 Ace Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Gnb1 Adcy2 Fshr Prkacb Cga Ppp1ca AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Cds2 Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Slc22a1 Cyp2d4 Cyp2b2 Ugt2b7 Ugt1a9 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Nfat5 Map2k1 Lck Grb2 Raf1 Hras Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Calm2 Mapk3 Rac1 Cd79b Ppp3ca Lyn Jun Ppp3cb Orai1 Syk Blnk Fos Map3k1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gngt1 Gnb1 Plcb1 Chrm1 Htr2c PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl35a Fau Rpl23a Eprs1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl35a Farsa Fau Farsb Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ren1 Ace Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm Pklr Pgk1 Eno1 G6pc1 Slc2a2 Pgam2 Pfkm Gpi Galm Hk2 Aldoa ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp2d4 Sult2a1 Abcc4 Abcc5 Gstp1 Gstt1 Ugt2b35 Abcb1a Abcg2 Abcc1 Pdia2 Sdf2l1 Ugt1a6a Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a9 Erp29 Cyp2a3 Ugt1a1 Hspa5 Cyp2e1 Sult1a1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Bckdha Pccb Dbt Dld Sds Bckdhb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mthfs Ftcd Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Ggh Mthfd1 Mthfd2 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Cyp2d4 Cbr1 Ugt1a9 Alox12 Cyp2c11 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl35a Fau Rpl23a Aars1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcc3 Cdkn1a Tp53 Abcb1a Ralbp1 Abcc1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Cbr1 Alox12 Prxl2b Pla2g2a Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhb Sdha Mt-co1 Cycs Ndufa1 Mt-atp6 Uqcrc1 Atp5f1d Atp5pb Atp5f1c Atp5mc2 Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 Sdhd Sdhc VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Nqo1 Vkorc1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ren1 Ace Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Bpnt1 Nudt3 Ip6k1 Inpp5j Itpka Inpp4a Inpp4b Ipmk Impa1 Isyna1 Itpk1 Ippk BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Lss Sqle Pmvk Acat1 Hmgcr Fdps Hmgcs1 Idi1 Mvd Fdft1 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Tpi1l2 Pkm Pfkp GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Chat Ptpmt1 Dgka Chka Agpat1 Gpd2 Cds1 Pgs1 Pla2g2d Ptdss1 Gpam Ptdss2 Cdipt Gpd1 Plpp1 Crls1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfp C8a Cfb Cfd C3 C5 C6 C7 C9 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp2d4 Cyp3a73 Cyp2c11 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Ugt8 Sptlc1 Acer2 Cerk Sptlc2 Enpp1 Degs2 Samd8 B4galt2 Sphk2 Gla Ugcg Sdr16c5 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod3 Sod2 Sod1 Cat NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Hyou1 Pdia6 Pdia4 Bche Cyp3a73 Ppib Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 Abcb1a Abcg2 Abcc1 Pdia2 Sdf2l1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ren1 Ace Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Sdhb Mdh1 Sdha Cs Tktl1 H6pd Idh3g Pfkm Pdhx Aldoc Mpc1 Gls Acly Fh Ogdh Idh1 Pgk2 Slc16a1 Idh3a Ireb2 Rpia Aco1 Gpi Taldo1 Pkm Bckdhb Eno1 Glud1 Slc2a13 Cad Gapdhs Bpgm Sdhd Sdhc PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcc3 Cdkn1a Tp53 Abcb1a Ralbp1 Abcc1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Map2k1 Mapk1 Ins2 Grb2 Raf1 Plcg1 Hras Prkca Shc1 Irs1 Insr Ptpn6 Ghr Stat5a Stat5b Mapk3 Rps6ka1 Slc2a4 Sos1 Jak2 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Ca1 Atp1b1 Scnn1a Atp1b3 Scnn1b Atp1b2 Scnn1g Ren1 Slc14a2 Atp1a2 Aqp3 Aqp2 Atp1a1 Atp6v1b1 Atp1a4 Slc4a1 Atp1a3 Fxyd2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd2 Gpd1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Pik3r4 Ptpmt1 Prex1 Inpp5f Plce1 Pik3c3 Inppl1 Zfyve16 Vac14 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Fas Fadd Faslg Dffa Daxx Dffb Mapk8 Faf1 Arhgdib Map3k7 Pak1 Ripk2 Prkdc Parp1 Cflar Pak2 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Jun Casp3 Casp6 Sptan1 Map2k4 Map3k1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Slco1b2 Abcb1a Abcg2 Abcc1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Pc Aars2 Agxt Mpc1 Gpt HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpia Tpi1l2 Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Prkca Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ren1 Ace Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Ugt1a2 Cbr1 Slc22a8 Ugt2b1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ugt2b7 Ppib Dnajb11 Ugt1a9 Alox12 Erp29 Cyp2c11 Prxl2b Cyp2u1 Ugt1a1 Alox5 Hspa5 Lta4h Akr1c18 Slc22a6 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Ca1 Slc22a2 Slc22a6 Slc4a4 Slc9a1 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Aqp1 Slc7a8 Slc7a9 Slc6a20a IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Map2k1 Grb2 Raf1 Plcg1 Hras Mapk8 Shc1 Epo Ptpn6 Elk1 Epor Stat5a Mapk3 Sos1 Jak2 Jun Fos CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp2d4 Ugt2b7 Oprm1 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Rpia Pgm1 Prps1 Gpi Pfkl Rpe G6pdx Fbp1 Pgls Tkt Aldob HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Aldh2 Gad1 Aoc3 Upb1 Dpys Cndp1 Aldh6a1 Abat Dpyd PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Gnaq Gnb1 Plcb1 Cacna1a Slc2a2 Adcy10 Chrm3 Vamp2 Prkca Rab3a Rapgef4 Cacnb1 Glp1r Camkk1 Itpr3 Abcc8 Cacna2d2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Htr6 Gngt1 Gnb1 Prkacb Ppp1ca METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a9 Cyp2d4 Cyp2b2 Oprm1 Grin2a Grin1 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Mettl6 Scly Slc39a8 Cbs Mat2a Cth GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Gnb1 Adcy2 Prkacb Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gbe1 Gpi Ganab Pgm2 Gys1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Farsa Farsb Got1 Hgd Fah Tat Pah Yars1 Hpd FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Rock1 Gnb1 Lpar4 Itpr1 Srf Plcb1 Akt1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Slc25a20 Pex11g Acsl1 Abcd2 Pex14 Abcd1 Crat Cpt2 Pex13 Crot CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Akr1d1 Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Ugt2b34l1 Hsd17b1 Cyp19a1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Asl Gad1 Adsl Nars1 Aspa Abat Ddo Asrgl1 Dars1 Ass1 Cad Asns CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Mapk1 Nfkb1 Itpr1 Plcb1 Raf1 Prkcb Mapk3 Hras Prkca Nfkbia Rela LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Ddc Comt Aoc1 Aldh2 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah Cyp2e1 Acss1 Aldh1b1 Cat GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Map2k1 Mapk1 Ins2 Grb2 Raf1 Plcg1 Hras Prkca Shc1 Irs1 Ptpn6 Ghr Stat5a Stat5b Mapk3 Rps6ka1 Slc2a4 Jak2 Gh1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Pc Aars2 Agxt Mpc1 Gpt MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Acss3 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Galk1 Uxs1 Ugp2 Pgm1 Ugdh Gck Gale Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Pik3r6 Vav1 Plcb1 Plcg1 Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat1 Npr1 Nampt Ppargc1a Clock Sirt1 Rora Nqo1 Nmnat2 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Gusb Fech Uros Hmox1 Blvra Ppox Flvcr2 Alad Cox15 Hmbs Ftmt Cpox Urod Ugt2b34l1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Creb1 Gngt1 Gnb1 Prkacb Ppp1ca Htr7 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Slc2a1 Eno1 Pgam2 Gpi Aldoart2 Galm Tpi1l2 Pkm Pfkp STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp2d4 Cyp1a2 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Slc9a1 Prkacb Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Prkar1b Kcnj2 Prkar2a Dlg1 Prkar2b Abcc8 Atp1b4 Kcnj11 Uqcr11 Abcc9 Cacna2d2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Cyp2b2 Fmo3 Chrna4 Aox1 Ugt1a9 Cyp2a3 Ugt1a5 Chrnb2 Chrna3 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Bbox1 Aldh9a1 Shmt1 Tmlhe Setd7 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Akr1b1 Lipc Lpl Plpp2 Gpd2 Aldh3a1 Agpat1 Gpam Gpd1 Plpp1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Nudt2 Adcy2 Entpd8 Gart Itpa Adk Nudt5 Abcc4 Dguok Tpmt Abcc5 Rrm2 Slc29a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Aox1 Slc28a3 Slc29a1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Nudt2 Adcy2 Entpd8 Gart Itpa Adk Nudt5 Abcc4 Dguok Tpmt Abcc5 Rrm2 Slc29a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Aox1 Slc28a3 Slc29a1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Got1 Gclc Cth Gclm Mpst Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Map2k1 Grb2 Raf1 Hras Stat6 Rasa1 Csnk2a1 Jak1 Egf Stat3 Srf Stat2 Stat1 Sos1 Egfr Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Mapk3 Jun Fos Map2k4 Map3k1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Mthfs Ftcd Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Ggh Mthfd1 Mthfd2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Tpi1l2 Gmppa Mpi Pmm1 Sord Uxs1 Akr1b1 Khk Pfkfb1 Gmds Pfkl Fbp1 Aldoa BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Aox1 Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs1 Ugp2 Pgm1 Ugdh Galk2 Gale Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ren1 Ace Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Tymp Ces1d Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Cacna1a Ugt2b35 Ugt1a2 Ugt2b1 Atp1a2 Atp1a1 Atp1a4 Pdia2 Atp1a3 Sdf2l1 Fxyd2 Hyou1 Pdia6 Pdia4 Ugt2b7 Ppib Dnajb11 Ugt1a9 Grin2a Erp29 Kcnd2 Scn1b Ugt1a1 Chrnb2 Hspa5 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acaa2 Acat1 Acadl Echs1 Acads Hadh Acss3 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Gnpat Cept1 Agpat1 Plpp1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Bpnt1 Sult2b1 Chst11 Papss2 Suox Sult1a1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ren1 Ace Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2d4 Ugt1a9 Cyp2c11 Ptgs1 Ptgs2 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1b2 Slc2a2 Gck Atp1a2 Atp1a1 Atp1a4 Treh Atp1b1 Atp1a3 Slc5a1 Atp1b3 Fxyd2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a9 Cyp2d4 Aox1 Maob Slc6a4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc25a22 Slc38a4 Slc2a2 Slc2a4 Glud1 Gpt Slc1a4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Slc28a3 Cmpk1 Rrm2 Slc29a1 Slc28a1 Ctps1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Sdhb Mdh1 Pklr Sdha Cs Dhtkd1 Pgk1 Idh3g Slc2a2 Pc Suclg1 Mpc1 Suclg2 Fh Slc1a5 Idh1 Slc16a1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Rpia Aco1 Dld Gpi Pfkl Hk2 Taldo1 G6pdx Pkm Tkt Eno1 Pgam2 Gls2 Glud1 Pgls Aldob Sdhd Sdhc ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Sdhb Mdh1 Sdha Cs Dhtkd1 Pgk1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Rpia Aco1 Dld Gpi Hk2 Taldo1 G6pdx Pkm Pfkp Tktl2 Pdha2 Eno1 Slc16a4 Slc1a2 Gls2 Glud1 Slc2a1 Aldoart2 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Ebp Dhcr7 Sc5d Lbr Cyp51a1 Hsd17b7 Msmo1 Nsdhl Dhcr24 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Jak1 Stat3 Mapk1 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Plcb4 Cct3 Ptpmt1 Synj1 Bpnt2 Ipmk Impa1 Pik3c3 Isyna1 Vac14 Becn1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Chuk Raf1 Hras Vav3 Rala Casp9 Cycs Pld1 Rhoa Ralbp1 Ralgds Smad3 Smad4 Apaf1 Elk1 Foxo4 Mapk3 Rac1 Bad Bcl2l1 Akt1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gnaq Agtr1 Gnb1 Cyp21a1 Cyp11a1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Egfr Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Got1 Gclc Cth Gclm Mpst Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Rock1 Gnb1 Itpr1 Srf Plcb1 Lpar5 Akt1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Cyp2b2 Cyp3a73 Aldh1a1 Aldh3a1 Cyp2c11 Cyp2a3 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Slc10a2 Gpbar1 Glp1r NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k1 Pik3cg Mapk1 Pik3r6 Ins2 Grb2 Raf1 Hras Mapk8 Shc1 Irs1 Insr Irs2 Slc2a4 Map2k2 Sos1 Pdpk1 Foxo1 Akt1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Lars1 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Nudt3 Ip6k1 Synj1 Bpnt2 Ipmk Impa1 Ppip5k1 Isyna1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Slc25a20 Pex11g Acsl1 Abcd2 Pex14 Abcd1 Crat Cpt2 Pex13 Crot ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Pik3r4 Synj1 Impa1 Pik3c3 Plcd4 Vac14 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Adcy2 Prkacb Drd1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a9 Cyp2b2 Cyp3a73 Ephx1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Ccnb1 Ccne1 Ccnd1 Gadd45b Cdk4 Cdkn1a Cdk2 Bax Bcl2 Cdk1 E2f1 Apaf1 Rb1 Pcna METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway Cfd C1qb C1qa C3 Serping1 C5 C1s C6 C1r C7 Masp2 C9 C2 C8a C4 Cfb Mbl2 C1qc MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma2 Psmb3 Psmc4 Psma1 Psmd4 Psmb2 Psmc3 Uba1 Ubd Psmd13 Psma4 Psmb5 Psmc6 Psma3 Ubc Psmc5 Psmb7 Psma6 Psma5 Psmb6 Psmb1 Psmc2 Psmc1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Akr1b1 Lipc Lpl Plpp2 Gpd2 Aldh3a1 Agpat1 Gpam Gpd1 Plpp1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Map2k1 Mapk1 Grb2 Raf1 Erbb4 Hras Cga Itpr1 Plcb1 Prkcb Gna11 Prkca Src Fshb Pld1 Mapk8 Lhb Gnrh1 Gnrhr Hbegf Camk2a Elk1 Adcy5 Cdc42 Map2k7 Egr1 Calm2 Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Jun Map3k1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Ugt2b7 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Tpi1l2 Mpi Aldob Pmm1 Sord Akr1b1 Khk Pfkfb1 Gmds Pfkl Fcsk Fbp1 Fpgt Aldoa Gfus BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Slc2a1 Eno1 Gpi Aldoart2 Hk2 Pkm Pfkp BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Ppp3cc Map2k1 Btk Grb2 Raf1 Hras Sos1 Vav1 Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Mapk3 Rac1 Cd79b Ppp3ca Lyn Jun Ppp3cb Orai1 Nfatc4 Syk Blnk Nfatc3 Fos Nfatc2 Map3k1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Rock1 Gnb1 Lpar1 Itpr1 Srf Plcb1 Akt1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Bdh1 Acat1 Hmgcl Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Asl Gad1 Adsl Nars1 Aspa Abat Ddo Asrgl1 Dars1 Ass1 Cad Asns LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Pcyt2 Chka Cept1 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Itpka Plcd1 Miox Cct3 Ptpmt1 Impa1 Isyna1 Itpk1 Vac14 Becn1 Inpp1 Sacm1l Pik3r4 Synj1 Ambra1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Dffa Hmgb2 Endog Casp7 Casp3 Cad GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Gngt1 Gnb1 Prkaca Prkacb Prkar1b Adcy10 Prkar2a Prkar2b GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Kars1 Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Tktl2 Rpia Pgm1 Prps1 Gpi Aldoart2 Taldo1 Rpe G6pdx Fbp1 Pfkp Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1qb C1qa C3 C5 C1s C6 C1r C7 C9 C2 C8a C4 C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Bpgm Eno1 G6pc1 Slc2a2 Pgam2 Pfkm Gpi Galm Tpi1l2 Pkm Aldob FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Sord Pfkfb2 Fbp1 Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Ins2 Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Gusb Fech Uros Hmox1 Blvra Ppox Flvcr2 Alad Cox15 Hmbs Ftmt Cpox Urod Ugt2b34l1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Gusb Fech Uros Hmox1 Blvra Ppox Flvcr2 Alad Cox15 Hmbs Ftmt Cpox Urod Ugt2b34l1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Sord Gpi Pfkfb2 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Hyou1 Pdia6 Pdia4 Abcc3 Cyp3a73 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Abcb1a Ptgs1 Pdia2 Sdf2l1 Ptgs2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Gab2 Slc22a1 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Abcb1a Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Ddc Aldh2 Haao Aanat Tph1 Asmt Kmo Inmt Wars2 Wars1 Tdo2 Cyp1a1 Kynu Acmsd Ido1 Aadat Cat LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Aldh2 Cyp2e1 Acss1 Aldh1b1 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Akr1b1 Lipc Lpl Plpp2 Gpd2 Aldh3a1 Agpat1 Gpam Gpd1 Plpp1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl35a Fau Rpl23a Gars1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Gaa Akr1b1 Ugp2 Glb1 G6pc1 Pgm1 B4galt1 Lct Gla Gale Galt BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Ebp Dhcr7 Sc5d Lbr Cyp51a1 Hsd17b7 Msmo1 Nsdhl Dhcr24 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Farsa Farsb Got1 Hgd Fah Tat Pah Yars1 Hpd VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Slco1b2 Abcb1a Abcg2 Abcc1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Aifm2 Sirt1 Cd38 Nqo1 Nmnat2 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhb Sdha Cs Dhtkd1 Idh3g Me1 Pc Suclg1 Mpc1 Suclg2 Got2 Acly Fh Slc1a5 Slc1a4 Idh2 Slc16a1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Slc38a5 Gls2 Glud1 Slc7a7 Sdhd Sdhc PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpia Tpi1l2 Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1b2 Ren1 Slc12a6 Slc12a1 Atp1a2 Atp1a1 Atp1a4 Atp1b1 Atp1a3 Atp1b3 Fxyd2 Clcnkb FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Mthfs Ftcd Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Ggh Mthfd1 Mthfd2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl35a Fau Rpl23a Eprs1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Gnaq Gnai1 Map2k1 Gnb1 Mapk1 Nfkb1 Raf1 Crk Plcg1 Hras Ptk2b Gngt1 Mapk3 Cxcl12 Pxn Pik3c2g Ptk2 Nfkbia Bcar1 Cxcr4 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agtr1 Ren1 Ace Agt DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Cyp2d4 Cacna1a Cyp3a9 Aox1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Maob Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Fbp2 Pfkm Tpi1l2 Aldoc Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Pc Aars2 Agxt Mpc1 Gpt TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Atf1 Casp2 Nfkb1 Ripk1 Chuk Tank Tnf Map2k6 Map4k2 Map2k3 Tradd Cradd Traf2 Mapk8 Map2k7 Ikbkb Mapk14 Jun Ikbkg Nfkbia Map2k4 Map3k1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Pik3r6 Plcb1 Plcg1 Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Acaa2 Slc25a20 Cpt1a Acsl1 Hadha Hadhb Acadl Cpt2 Echs1 Hadh INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Inpp1 Itpka Inpp4a Ipmk Impa1 Ppip5k1 Nudt4 Isyna1 Ip6k2 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Aldob Pank3 Bpgm G6pc1 Gpi Fbp1 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Fmo3 Cacna1a Aox1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Ugt1a9 Grin2a Kcnd2 Ugt1a5 Cyp2a3 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Cyp2b2 Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Chrna3 Cacna2d2 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Gusb Fech Uros Hmox1 Blvra Ppox Flvcr2 Alad Cox15 Hmbs Ftmt Cpox Urod Ugt2b34l1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Aoc1 Aldh2 Aldh3a1 Cndp1 Uroc1 Hdc Ftcd Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Hal PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Iars1 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Mdh2 Slc25a11 Got2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Itpa Rrm2 Cad Cant1 Nme6 Dhodh Tyms Tymp Rrm2b Cda Upb1 Gda Dpys Ak3 Ctps1 Cmpk2 Upp2 Dctd Dpyd Uckl1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Gnmt Dmgdh Bhmt Shmt2 Sardh Mat2a Slc44a1 Mtr Shmt1 Chdh Aldh7a1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C2 C4 C8a Mbl2 C3 C5 C6 C7 C9 Masp2 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Tymp Ces1d Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rars1 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Aldh2 Gad1 Aoc3 Upb1 Dpys Cndp1 Aldh6a1 Abat Dpyd TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Mdh1 Pdhb Me1 Pc Slc25a11 Mpc1 Acly CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Cyp2b2 Cyp3a73 Cyp1a2 Cyp2c11 Pon1 Abcb1a P2ry12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Ins2 Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Adra1a Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Acaa2 Hadha Hadhb Mecr Ppt1 Echs1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Itpa Rrm2 Cad Cant1 Nme6 Dhodh Tyms Tymp Rrm2b Cda Upb1 Gda Dpys Ak3 Ctps1 Cmpk2 Upp2 Dctd Dpyd Uckl1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Il4 Il5 Map2k1 Btk Mapk1 Kras Pdk1 Ms4a2 Grb2 Nras Raf1 Csf2 Pik3r1 Lcp2 Lat Hras Inpp5d Sos1 Gab2 Tnf Map2k6 Plcg1 Map2k3 Vav3 Prkca Mapk8 Map2k7 Fyn Map2k2 Rac1 Mapk14 Lyn Il13 Syk Pla2g4a Fcer1a Akt1 Map2k4 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Tktl1 Fbp2 H6pd Rpia Prpsap1 Pfkm Gpi Taldo1 Rpe Rbks Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Gls2 Mpc1 Glud1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Sdhd Sdhc PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Tktl2 Pgm1 Prps2 Rpe Pgls Rpia Gpi Aldoart2 Taldo1 G6pdx Fbp1 Pfkp Rbks SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Creb1 Mapk1 Nfkb1 Plcb1 Mapk3 Ikbkb Nos3 Prkca Ikbkg METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Asl Gad1 Adsl Nars1 Aspa Abat Ddo Asrgl1 Dars1 Ass1 Cad Asns ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Ggt6 Csad Ado Cdo1 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Nudt2 Adcy2 Entpd8 Gart Itpa Adk Nudt5 Abcc4 Dguok Tpmt Abcc5 Rrm2 Slc29a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Aox1 Slc28a3 Slc29a1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Ngf Fgf1 Ccnd1 Tp53 Rb1 Chaf1a Hoxb9 Btg2 Btg1 Prmt1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Ins2 Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Adcy10 Nos3 Gucy1a2 Trpv4 Prkg2 Gucy1a1 Trpc7 Trpc4 Kcnq4 Trpc3 Kcnq3 Kcnq2 Gucy1b1 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d4 Cyp1a2 Cyp2c11 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Slc22a1 Abcc3 Pcyt1a Pgk1 Pcyt2 Abcc4 Slc22a2 Abcb1a Abcg2 Abcc1 Cmpk1 Dck Slc22a3 Nme1 Chpt1 Sult1a1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp2d4 Abcb1a Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Galk1 Uxs1 Ugp2 Pgm1 Ugdh Gck Gale Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Hyou1 Pdia6 Pdia4 Abcc3 Cyp3a73 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Abcb1a Ptgs1 Pdia2 Sdf2l1 Ptgs2 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Aqp7 Slc2a1 Slc2a4 Pnp As3mt Gsto1 Aqp9 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Farsa Farsb Got1 Hgd Fah Tat Pah Yars1 Hpd HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Inpp1 Nudt3 Ip6k1 Itpka Synj1 Inpp4b Impa1 Ppip5k1 Isyna1 Itpk1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl35a Fau Rpl23a Sars1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Rock1 Gnb1 Lpar2 Itpr1 Srf Plcb1 Akt1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Fgf19 Fgfr3 Slc10a2 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc3 Eno1 Gpi Galm Tpi1l2 Pkm Pfkp Slc2a13 Pgk2 Aldob Gapdhs PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Scn5a Cacna1a Snta1 Slc2a2 Sntb1 Gcg Abcc8 Cacnb1 Cacna2d2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Tpi1l2 Mpi Aldob Pmm1 Sord Akr1b1 Khk Pfkfb1 Gmds Pfkl Fcsk Fbp1 Fpgt Aldoa Gfus BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Slc25a20 Pex11g Acsl1 Abcd2 Pex14 Abcd1 Crat Cpt2 Pex13 Crot INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Gngt1 Gnb1 Adcy2 Prkacb Ptgir Myl3 Mylk CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Nfkb1 Chuk Ecsit Mapk8 Tollip Irak1 Myd88 Map3k7 Tlr7 Tab2 Tlr6 Cd14 Tlr5 Tirap Tlr4 Ikbkb Tlr3 Tlr2 Mapk14 Traf6 Ikbkg Nfkbia Rela Map2k4 Map3k1 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Hyou1 Pdia6 Pdia4 Bche Cyp3a73 Ppib Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 Abcb1a Abcg2 Abcc1 Pdia2 Sdf2l1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Tktl1 Fbp2 H6pd Rpia Prpsap1 Pfkm Gpi Taldo1 Rpe Rbks Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Enpp1 Pank1 Vnn1 Ppcdc Coasy METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ren1 Ace Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map3k4 Nfkb2 Mapk1 Nfkb1 Prkcz Rap1a Chuk Rapgef3 Rapgef2 Mapk11 Hras Creb1 Gngt1 Prkacb Rps6ka1 Bad Gnb1 Map2k6 Mapk8 Pak1 Elk1 Map2k7 Ikbkb Map2k2 Pdpk1 Jun Atf2 Arhgef7 Adora2a Nfkbia Braf Akt1 Map3k1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Mthfs Ftcd Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Ggh Mthfd1 Mthfd2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Acss3 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Acaa2 Hadha Hadhb Mecr Ppt1 Echs1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Tars1 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhb Mdh1 Pklr Sdha Cs Dhtkd1 Pgk1 Suclg1 Slc1a3 Mpc1 Gls Fh Idh1 Slc16a1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Rpia Aco1 Dld Gpi Pfkl Hk2 Taldo1 G6pdx Pkm Tkt Eno1 Pgam2 Glud1 Sdhd Sdhc PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Galk1 Uxs1 Ugp2 Pgm1 Ugdh Gck Gale Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl35a Fau Rpl23a Aars1 Rpl4 Rps14 Rpl3 Rps15a Rps15 Rps18 Rps19 Rpl8 Rpl9 Rpl35 Rpl38l1 Rpl37 Rps20 Rpsa Rps24 Rpl39 Rps10 Rps11 Rpl7 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rps6 Rpl24 Rplp2 Rpl26 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl14 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl27a Rps21 Rps23 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcc3 Cdkn1a Tp53 Abcb1a Ralbp1 Abcc1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Adra1a Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ren1 Ace Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq6 Coq7 Coq2 Coq3 Coq5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Sdhd Sdhc TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Aoc1 Aldh2 Aldh3a1 Cndp1 Uroc1 Hdc Ftcd Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Hal CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a73 Pde4d MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Acaa2 Slc25a20 Hadha Acadm Hadhb Echs1 Hadh ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Bpnt1 Sult2b1 Chst11 Papss2 Suox Sult1a1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Akr1c1 Hyou1 Akr1d1 Pdia6 Pdia4 Ppib Dnajb11 Cyp11b3 Erp29 Ugt1a1 Hspa5 Hsd11b1 Srd5a1 Hsd17b3 Cyp19a1 Pdia2 Sdf2l1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Cyp2b2 Aldh1a1 Gstm2 Aldh3a1 Cyp2c11 Cyp2a3 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pc Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 Sdhd Sdhc BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Tktl1 Fbp2 H6pd Rpia Prpsap1 Pfkm Gpi Taldo1 Rpe Rbks Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Pcyt2 Chka Cept1 Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Yars1 Rps21 Rps23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Bpgm G6pc3 Eno1 Gpi Galm Tpi1l2 Pkm Pfkp Slc2a13 Pgk2 Aldob Gapdhs LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpka Miox Ptpmt1 Inpp4a Ipmk Pikfyve Impa1 Isyna1 Itpk1 Vac14 Ippk Becn1 Inpp1 Pik3r4 Plcd3 Pik3c3 Fig4 Ambra1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2d5 Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Cyp2b2 Acadsb Cyp2c11 Ehhadh Cyp2a3 Hadha Hadhb Ivd Ugt1a2 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl35a Fau Rpl23a Dars1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1b2 Slc2a2 Lct Atp1a2 Atp1a1 Atp1a4 Atp1b1 Atp1a3 Slc5a1 Atp1b3 Fxyd2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ren1 Ace Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Scn5a Snta1 Sntb1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Cyp2d4 Cyp2b2 Cyp3a73 Aldh1a1 Ugt1a9 Cyp2c11 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Prkca Nrg2 Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Limk1 Arfip2 Ccnd1 Pdgfra Rps6kb1 Cdkn1a Vav3 Mylk Pld1 Ralbp1 Pak1 Cap1 Ccnd3 Rac1 Wasf1 Cfl1 Ppp1r12b Actb Cdk5 Pcna Map3k1 Myl2 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm Pklr Pgk1 Eno1 G6pc1 Slc2a2 Pgam2 Pfkm Gpi Galm Hk2 Aldoa METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Fadd Nfkb1 Ripk1 Tnfrsf1b Chuk Il1a Tnf Tnfrsf1a Il1r1 Camkk2 Map3k14 Tradd Irak1 Camkk1 Myd88 Map3k7 Tlr4 Ikbkb Ubc Traf6 Ikbkg Nfkbia Rela Map3k1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Cyp2b2 Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Gusb Fech Uros Hmox1 Blvra Ppox Flvcr2 Alad Cox15 Hmbs Ftmt Cpox Urod Ugt2b34l1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Akr1d1 Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Ugt2b34l1 Hsd17b1 Cyp19a1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Ahcy Bhmt Mat2a Mtr Chdh Aldh7a1 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ren1 Ace Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Cars1 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Gab2 Cbl Crkl Rps6kb1 Myc Grb2 Mdm2 Tp53 Pik3r1 Cdkn1b Crk Skp2 Mtor Stat5a Sos1 Jak2 Bad Bcl2l1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Pc Aars2 Agxt Mpc1 Gpt CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Ugt2b7 Cyp3a73 Ces2h Ces1d Slco1b2 Ugt1a9 Impdh1 Abcb1a Abcg2 Impdh2 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Aldh1a1 Dnajb11 Erp29 Cyp2a3 Ugt1a1 Hspa5 Cyp2b2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Ddc Comt Aoc1 Got1 Dct Hgd Aldh3a1 Haao Mif Dbh Tyr Fah CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 Tpo HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Tpi1l2 Mpi Aldob Sord Akr1b1 Khk Pfkfb1 Pmm2 Pfkl Tgds Amigo3 Fcsk Fbp1 Fpgt Gfus INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm Pklr Pgk1 Eno1 G6pc1 Slc2a2 Pgam2 Pfkm Gpi Galm Hk2 Aldoa ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Cacna1a Slc2a2 Abcc8 Sst Cacnb1 Cacna2d2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Pik3cg Pik3r6 Ins2 Rps6kb1 Mtor Irs1 Insr Irs2 Slc7a5 Tsc2 Eif4ebp1 Tsc1 Eif4e Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Gch1 Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Spr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Bdh1 Acat1 Hmgcl Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Sirt3 P4ha3 Nlrp3 Tlr4 Hif1a Il1b GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Ugt2b7 Cyp3a73 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Oprk1 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Gngt1 Gnb1 Prkacb Htr4 Ppp1ca ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Hyou1 Comt Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp1a1 Hsd17b1 Pdia2 Sdf2l1 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpka Plcd1 Miox Cct3 Ptpmt1 Inpp4a Ipmk Impa1 Isyna1 Itpk1 Vac14 Ippk Becn1 Bpnt1 Sacm1l Inpp5j Pik3r4 Pik3c3 Ambra1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb Acadm Echs1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Nfkb1 Chuk Eif2ak2 Ppara Map2k6 Map2k3 Ecsit Mapk8 Tollip Irak1 Myd88 Map3k7 Tlr7 Tab2 Elk1 Cd14 Tirap Tlr4 Ikbkb Tlr3 Tlr2 Mapk14 Traf6 Jun Ikbkg Fos Nfkbia Rela Map2k4 Map3k1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Cds2 Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Ppp3cc Map2k1 Nfkb1 Lck Rasgrp1 Grb2 Raf1 Zap70 Pik3r1 Lat Hras Sos1 Pik3cg Vav1 Prkcb Plcg1 Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Nfatc4 Nfatc3 Fos Nfkbia Nfatc2 Rela Map2k4 Map3k1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Adk Abcc4 Tpmt Abcc5 Slc29a2 Gmps Hprt1 Ppat Xdh Aox1 Slc28a3 Slc29a1 Impdh1 Rac1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Mthfr Msrb3 Srm Msrb2 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Itpa Rrm2 Cad Cant1 Nme6 Dhodh Tyms Tymp Rrm2b Cda Upb1 Gda Dpys Ak3 Ctps1 Cmpk2 Upp2 Dctd Dpyd Uckl1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Aldh2 Nos1 Itpr1 Prkacb Xdh Grin2a Dlg4 Ppp3ca Prkca Grin1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Sdhb Mdh1 Sdha Cs Dhtkd1 Pgk1 Pc Suclg1 Mpc1 Gls Suclg2 Fh Idh1 Idh3a Dlst Pdhb Dlat Rpia Aco1 Dld Gpi Taldo1 G6pdx Pkm Pfkp Tktl2 Eno1 Slc16a4 Pgam2 Glud1 Pgls Slc2a1 Aldoart2 Sdhd Sdhc TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Aox1 Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gmps Gls2 Glud1 Got2 Gpt Qars1 Nagk Cad Gnpnat1 Gfpt1 Ppat Gad1 Gss Gclc Gclm Abat Cps1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pik3cd Pip4k2a Plcb1 Pik3r1 Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp2d4 Cyp3a73 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Cyp2c11 Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Got1 Gclc Cth Gclm Mpst Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Slc10a2 Abcc4 Gpbar1 Slco1a4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Slc25a20 Acsl1 Aldh2 Phyh Abcd2 Hacl1 Pex14 Abcd1 Crat Cpt2 Pex13 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 Fbp1 Aldoa GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Cacnb1 Grin1 Atp1b1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cacna2d2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Mdh1 Pklr Aldh2 Glo1 Me1 Acat1 Hagh Acaca Pc Acyp1 Acot12 Pck1 Pdhb Akr1b1 Dlat Dld Grhpr TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Acads Acaa2 Bcat1 Acadsb Auh Aox1 Dld Hmgcl Hibch Oxct1 Hmgcs2 Aldh6a1 Mccc1 Acadm Hibadh Abat Ivd Mccc2 Bckdhb Echs1 Bckdha Pccb Dbt Acat1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Acer1 Sphk2 Arsa Gla Sgpl1 Ugcg Acer3 Enpp7 Plpp1 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Akr1c1 Akr1d1 Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Gcat Gnmt Aldh2 Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Gamt Cth Shmt1 Sds Gars1 Gatm Psat1 Amt Phgdh GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pklr Eno1 G6pc1 Pgam2 Pfkm Gpi Galm Hk2 Tpi1l2 Aldoa CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gngt1 Gnb1 Prkacb Mc2r Pomc GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Cyp2b2 Cyp3a73 Aldh1a1 Aldh3a1 Cyp2c11 Cyp2a3 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Nos1 Prkacb Calm2 Grin2a Dlg4 Ppp3ca Prkca Grin1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Map2k1 Grb2 Raf1 Prkcb Erbb4 Plcg1 Hras Prkca Mapk8 Shc1 Rasa1 Csnk2a1 Egf Elk1 Stat3 Srf Map2k7 Stat5a Mapk3 Jak2 Jun Fos Map3k1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Rock1 Gnb1 Srf Lpar6 Akt1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Tpi1l2 Mpi Aldob Pmm1 Sord Akr1b1 Khk Pfkfb1 Gmds Pfkl Fcsk Fbp1 Fpgt Aldoa Gfus GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pklr Eno1 G6pc1 Pgam2 Pfkm Gpi Galm Hk2 Tpi1l2 Aldoa PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Slc25a15 P4ha3 Nos1 Got1 Asl Ckb Prodh1 Otc Glud1 Gamt Oat Arg1 Eprs1 Pycr2 Ass1 Gatm Dao Cps1 Rars2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Lipa Cyp27a1 Cyp46a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Fbp2 Pfkm Tpi1l2 Aldoc Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Hars1 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d4 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Creb1 Gngt1 Gnb1 Adcy2 Prkacb Cga Ppp1ca Lhb Lhcgr LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1b2 Slc2a2 Lct Atp1a2 Atp1a1 Atp1a4 Atp1b1 Atp1a3 Slc5a1 Atp1b3 Fxyd2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Mdh2 Eno1 Pgm1 Slc2a2 Pgam2 Pc Slc25a11 Galm Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 Pank1 Slc37a4 Fbp1 Aldoa GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Akr1b1 Lipc Lpl Plpp2 Gpd2 Aldh3a1 Agpat1 Gpam Gpd1 Plpp1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Tpi1l2 Pkm Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gbe1 Gpi Ugt2b34l1 Amy2a3 Hk2 Gys2 Gck Pgm2l1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Agpat1 Gpam Gpd1 Lpin1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Gnaq Agtr1 Gnb1 Ren1 Ace Agt CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Aldh2 Gad1 Aoc3 Upb1 Dpys Cndp1 Aldh6a1 Abat Dpyd GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck Pgm2l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dhtkd1 Acmsd Dld Aldh8a1 Dlst BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl35a Fau Rpl23a Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Wars1 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Inpp1 Nudt3 Ip6k1 Itpka Inpp4a Inpp4b Ipmk Impa1 Ppip5k1 Isyna1 Itpk1 Ippk ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc7a2 Aass Dhtkd1 Acat1 Dld Gcdh Aadat Echs1 Pipox Hadh Aldh7a1 Dlst ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb Hrh1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Acss3 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Akr1d1 Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Ugt2b34l1 Hsd17b1 Cyp19a1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Fbp2 Pck2 Gpi KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp4a Atp4b Slc8a1 Atp1b1 Atp1b3 Trpv5 Atp1b2 Ren1 Atp1a2 Aqp3 Aqp2 Atp1a1 Slc12a3 Atp1a4 Atp1a3 Fxyd2 Clcnkb ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Slc25a15 Asl Otc Arg1 Gls2 Glud1 Got2 Gpt Slc1a5 Ass1 Slc1a4 Cps1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Il4 Map2k1 Mapk1 Kras Lck Ms4a2 Grb2 Nras Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Gab2 Tnf Plcg1 Prkca Mapk8 Map2k7 Fyn Map2k2 Rac1 Lyn Il13 Syk Blnk Fcer1a Akt1 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Mapk1 Nfkb1 Plcb1 Chuk Mapk11 Nos3 Prkca Creb1 Sucnr1 Mapk3 Ikbkb Ptgs1 Ikbkg TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Fmo1 Cyp2d4 Cyp2b2 Fmo3 Cyp3a73 Esr1 Ugt1a9 Ugt1a5 Sult1a1 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Apaf1 Casp1 Prf1 Parp1 Arhgap32 Casp8 Jun Casp9 Cycs Casp3 Arhgdib FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Fbp2 Pfkm Tpi1l2 Aldoc Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gclc Gpx1 Ggt6 Gclm Gsto2 Anpep Oplah Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl35a Fau Rpl23a Nars1 Rpl4 Rps14 Rpl3 Rps15a Rps18 Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rpl24 Rplp2 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rps16l1 Rplp0 Rpl22 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Bpgm G6pc3 Eno1 Gpi Galm Tpi1l2 Pkm Pfkp Slc2a13 Pgk2 Aldob Gapdhs INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Creb1 Gngt1 Gnb1 Adcy2 Prkacb Ppp1ca Hrh2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gnb1 Itpr1 Plcb1 Lpar3 Akt1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Gls2 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Sdhd Sdhc GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Fasn Acsl5 Acsl6 Scd1 Acsl3 Acacb Acaca Hadh Mecr Echdc3 Echdc1 Echdc2 Decr1 Acly Echs1 Acaa2 Pc Acsl1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260710%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260710%WP469%RATTUS NORVEGICUS Glutathione metabolism Ggt5 Gpx3 Gss Anpep Gstm6 Gstm3 Gstm2 G6pdx Gstt2 Gstt1 Gclm Ggt1 Oplah STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd17b2 F13b Cyp17a1 Hsd3b6 Hsd17b7 Hsd3b5 Hsd17b3 Hsd3b1 Hsd17b4 Hsd17b1 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260710%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Adh4 Aldh1a1 Adh1 Cyp2e1 Aldh2 Cyp1a1 Cyp4a2 Cyp3a2 Adh7 Adh6 Acad10 Adh5 GPCRS OTHER%WIKIPATHWAYS_20260710%WP409%RATTUS NORVEGICUS GPCRs other Prokr2 Adora2a Adgrg1 Cxcr1 Ednra Gnrhr Ntsr1 Grm1 Htr7 Fshr Grm8 Htr2a Gpr61 Or1n1 Ccr5 Ccr2 Gpr176 Adra1d Cckbr Alg6 Adgrl2 Adgrl3 Gpr135 Sstr2 Smo Htr1f Taar3 Rxfp3 Taar2 Rxfp1 Taar5 Ghrhr Gpr183 C5ar2 F2r Or3a1e Or2a5 Chrm3 Ptgfr Chrm2 Hrh4 Gpr88 Or2f1 S1pr1 Drd3 Drd4 Celsr2 Cnr1 Gpr18 Grpr Uts2r P2ry13 Gpr17 Ltb4r2 Lgr6 Or10a2 BURN WOUND HEALING%WIKIPATHWAYS_20260710%WP5057%RATTUS NORVEGICUS Burn wound healing Il10 Adora2b Epo Dll4 Pdgfa Arfgap1 Ccn2 Tp53 Acta1 Jun Col1a1 Syk Casp3 Col4a1 Chp1 Ankrd1 Igf1 Syp Mmp9 Ptgis Il1rl1 Glb1 Il1b Cdc25b Gpr176 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260710%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Ace Nos3 Agtr1b Kng2l1 Agtr2 Bdkrb2 Kng2 Agt Ren1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260710%WP1302%RATTUS NORVEGICUS Estrogen metabolism Sult1e1 Cyp1a1 Nqo1 Gstm1 Comt Sult1a1 Arsl Cyp1b1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260710%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton F2r Chrm3 Chrm2 Pdgfa Ins1 Ins2 Mapk1 Fgf2 Fgf1 Fgf4 Mapk3 Fgf3 Mapk4 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Cfl1 Cfl2 Egfr Actb Nras Pip4k2b Pfn1 Ezr Raf1 Vcl Pip4k2a Arhgef7 Arhgef6 Arhgef1 Pxn Myh10 Chrm1 Nckap1 Chrm5 Chrm4 Pdgfrb Itga1 Pdgfra Rras2 Pik3cg Slc9a1 Actg1 Pik3cd Pik3ca Pik3c2b Pik3c2a Ssh3 Fgfr3 Pik3c2g Ptk2 Ssh2 Fgfr4 Ssh1 Fgfr1 Fgfr2 Mylk Arpc5 Cd14 Fgf16 Fgf17 Fgf14 Fgf18 Fgf19 Braf Fgf12 Fgf13 Pik3c3 Fgf10 Rhoa Fgf11 Enah Rac1 Baiap2 Git1 Fgf20 F2 Fgf23 Rras Pik3r5 Rassf7 Sos2 Pik3r1 Crk Sos1 Pik3r2 Pik3r3 Gna12 Gna13 Dock1 Fgd1 Bcar1 Pak1 Pak6 Csk Pak3 Pak2 Pak5 Pak4 Cdc42 Tmsb4x Arhgap35 Wasf2 Gsn Wasf1 Egf Mos Map2k1 Apc Limk1 Rock1 Pip5k1b Pip5k1a INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260710%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Fblim1 Rab7a Rab11a Ezr Cftr Nherf1 ADIPOGENESIS%WIKIPATHWAYS_20260710%WP155%RATTUS NORVEGICUS Adipogenesis Nr3c1 Lpl Gh1 Il6 Tgfb1 Hif1a Dvl1 Id3 Gtf3a Ndn Cisd1 Pck1 Pck2 Egr2 Lif Bmp4 Bmp3 Wwtr1 Stat5a Bmp2 Stat5b Bmp1 Lipe Hnf1a Hmga1 Plin2 Adipoq Necab3 Epas1 Rara Slc2a4 Foxo1 Sfrp4 Nr2f1 Ppard Ppara Pparg Rbl2 Rbl1 Klf15 Ncor1 Il6st Ucp1 Gadd45b Gadd45a Pnpla3 Cebpd Mef2d Cebpb Ncoa2 Zmpste24 Ncoa1 Rb1 Asip Osm Lpin3 Ppargc1a Celf1 Lpin1 Dlk1 Mixl1 Mef2a Mef2b Mef2c Klf5 Lep Spock1 Stat3 E2f1 Fas Cdkn1a Gdf10 Agpat2 Srebf1 Igf1 Ptgis Agt Ins2 Socs3 Scd1 Nampt Nrip1 Trib3 Ahr Irs2 Tnf Lifr Prlr Bscl2 Cyp26b1 Foxc2 Wnt5b Twist1 Nr1h3 Ebf1 Mif Retn Rxra Cyp26a1 Mbnl1 Frzb Cntfr Gata3 Serpine1 Gata4 Rxrg Gata2 Cfd BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260710%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Lpl Acsl5 Acsl6 Acsl3 Hadh Hadha Hadhb Gcdh Crat Tpi1 Acadm Cpt2 Acads Pnpla2 Acadvl Cpt1a Gpd2 Lipe Lipf Acsl4 Dld Acat1 Echs1 Acsl1 FOLIC ACID NETWORK%WIKIPATHWAYS_20260710%WP1311%RATTUS NORVEGICUS Folic acid network Mtr Selenow Kmo Sod1 Ptgds Txnrd2 Cbs Cat Pnpo Xdh Mt-co2 Mthfr Selenok Gpx3 Fads2 Ptgis Mt-co1 Gpx1 Gpx6 Alox5 Msrb1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260710%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Smpd2 Mapk12 Plcb3 Plcb2 Mapk1 Plcb1 Asah1 Sphk2 Akt3 Mapk3 Akt2 Sphk1 Mapk4 Akt1 Gnai1 S1pr3 Pik3c2b S1pr1 Gnai3 TCA CYCLE%WIKIPATHWAYS_20260710%WP347%RATTUS NORVEGICUS TCA cycle Sdhb Sdha Idh3b Afdn Pdha1 Suclg1 Suclg2 Pdk4 Pdk3 Ogdh Pdk2 Dld Fh Mdh1 Mdh2 Pdhb Pc Sdhc AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260710%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Gstm1 Akr7a3 Akr7a2 Ephx1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260710%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Gprc5b Gprc5a Casr Gprc5d Gprc5c Grm3 Grm2 Grm5 Grm1 Grm4 Grm7 Gabbr1 Grm6 Grm8 Gabbr2 RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260710%WP376%RATTUS NORVEGICUS Renin angiotensin system Raf1 Pik3ca Mapk9 Atf2 Ikbkb Mapk8 Ctsg Ptk2 Ikbkg Elk1 Jak2 Cpa3 Mme Agtr1 Prkaca Prkcq Fos Rela Ace2 Ptgir Enpep Map3k1 Ctsa Shc1 Map2k7 Nln Cma1 Lnpep Mapk13 Rac1 Ptk2b Map2k4 Mas1 Grb2 Itpr3 Itpr2 Mapk10 Itpr1 Stat3 Pak1 Pak6 Pak3 Pak2 Pak5 Pak4 Jun Ren1 Ace Agtr2 Agt Anpep Mapk1 Plcb1 Mapk3 LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260710%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Gpat2 Dgat2 Agpat5 Dgat1 Acsl3 Agpat3 Fitm2 Agpat4 Agpat1 Agpat2 Bscl2 Pnpla2 Gpd2 Lpin3 Plin2 Lpin1 Soat1 Aup1 Lipa Acsl1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260710%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Fas Casp7 Casp9 Cycs Casp6 Aifm1 Hspa1b Map3k1 Casp2 Ripk1 Tnfrsf1a Nfkb1 Fadd Casp3 Faslg Bid Mapk10 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Raf1 Stat5a Stat5b Pik3cg Mapk9 Atf2 Elk1 Jak2 Shc1 Rac1 Ptk2b Grb2 Pik3r1 Pik3r2 Stat3 Jun Nfkb1 Syk Rap1gap Pla2g4a Ctnnb1 Crkl Itgam Pim1 Foxo3 Jak1 Sox4 Alox5 Sdcbp Alox5ap Hcls1 Gsk3b Hck Gsk3a Prkcb Rps6ka1 Itgb2 Prkcd Il5ra Btk Shc2 Unc119 Ptpn6 Il5 Ptpn11 Lyn Mapk14 Mapk1 Sh2b2 Nfkbia Rapgef1 Bax Mapk3 Cdkn1b Hras Akt1 MRNA PROCESSING%WIKIPATHWAYS_20260710%WP529%RATTUS NORVEGICUS mRNA processing Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf4 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt1 Prmt2 Cstf2 Dhx16 Cstf3 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Celf1 Srrm1 Rbm17 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Scamp3 Hnrnpa2b1 Supt5h Cdc40 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260710%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Ednra Pla2g4a Ednrb Ptgis Anxa8 Anxa6 Prl Ptgdr Ptger4 Ptger2 Ptger3 Cyp11a1 Ptger1 Ptgds S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Tbxas1 Edn1 Hpgd Ptgir Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Anxa1 Ptgs2 Ptgfr HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260710%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Grin2c Grin2b Prkaca Acta1 Mapk1 Grin2a Nisch Camk4 Krit1 Mapk3 Grm5 Terf2ip Grm1 Gria2 Camk2b Map2k1 Gria1 Ppa1 Prkce Drd1 Drd4 Grin1 Grin2d Adcy8 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260710%WP270%RATTUS NORVEGICUS Tryptophan metabolism Ddc Tph1 Aldh1a1 Aldh3a2 Aldh9a1 Inmt Cyp2e1 Aldh2 Cyp2j3 Hsd17b10 Cyp1a1 Cyp2b15 Ogdh Wars1 Cyp2j4 Tdo2 Gcdh Acad10 Cyp4f1 Cyp2f2 Aadat Cyp7b1 Aanat Afmid Aoc1 Dhcr24 Haao Asmt Cyp2d26 Kynu Mdm2 Cyp2a2 Cyp2a1 Echs1 Ube3a Acmsd Ido1 Cat Hadh Prmt1 Cyp1b1 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260710%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Pdha1 Pdk4 Pdk3 Pdk2 Pck1 Gpi Pdhx Psme3 Slc5a10 Sord Eno1 Eno3 Eno2 Khk Mpc1 Mpc2 Pgam2 Slc2a2 Pgam1 Akr1b1 Slc2a5 Pdk1 Gapdh Tkfc Ldha Ldhb Fbp1 Pklr Aldob Aldoc Aldoa Pfkl Pgk1 Slc5a1 Slc5a2 Pfkp Slc5a9 Got1 Got2 G6pc1 Hk1 Pdp1 Pdp2 Tpi1 Dld Acly Pc Mdh1 Mdh2 Pdhb METHYLATION%WIKIPATHWAYS_20260710%WP1282%RATTUS NORVEGICUS Methylation Pnmt Mat2a Inmt Mat1a Hnmt Comt COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP547%RATTUS NORVEGICUS Complement and coagulation cascades F13b F2r F2 Cr2 Serping1 Cr1l C3ar1 Serpinf2 Mbl1 Fgb Vwf Masp1 Masp2 Tfpi C8b F3 F7 F8 F9 Plaur Cfb C1qb C1qa Cd59b Cfh Cfi Plg Klkb1 C2 Kng2l1 Proc C4 C6 Kng2 C9 Serpind1 Cd46 F10 C1s C1r F12 Plat Thbd Plau Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc Serpine1 Cfd SPINAL CORD INJURY%WIKIPATHWAYS_20260710%WP2433%RATTUS NORVEGICUS Spinal cord injury Rgma Vcan Gja1 Ifng Il6 Sema6a Tgfb1 Lilrb2 Nos1 Sox9 Tnfsf13b Zfp36 Gap43 Arg1 Prpg2 Omg Plxna2 Epha4 Mag Rtn4r Tacr1 Prkca Tlr4 Ngfr Cxcl10 Pla2g2a Ccng1 Ntn1 Klk8 Necab3 Il2 Rtn4 Gfap Il4 Selp Bcan Tnfsf13 C5 Gdnf Ccl2 Pla2g5 Mbp Cd47 Fos Cxcl1 Cxcl2 Pla2g6 Ppp3ca Gadd45a Fcgr2a Egr1 Ccnd1 Nos2 Ptpra Ncan Acan Il1a Rb1 Xylt1 Nox4 Cdk1 Rock2 Il1r1 Vim E2f5 E2f1 Tp53 Casp3 Col4a1 Mmp9 Il1b Anxa1 Mapk1 Mapk3 Btg2 Chst11 Bdnf Fkbp1a Ptprz1 Slit1 Slit2 Aqp4 Grin1 Slit3 Pdyn MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP358%RATTUS NORVEGICUS MAPK signaling pathway Tgfb1 Prkca Ppp3ca Gadd45a Il1a Il1r1 Cacng8 Cacna1g Cacna1h Cacna1e Cacng7 Mef2c Cacna1f Cacna1c Cacna1d Cacna1a Cacna1b Cacng1 Fas Map3k8 Map3k7 Cacng4 Map3k6 Cacng5 Map3k5 Pdgfa Cacng3 Map3k4 Elk4 Tp53 Cacna1s Map3k20 Jun Lamtor3 Map3k2 Prkcg Casp3 Flna Rasgrp3 Rasgrp4 Rasgrp1 Flnc Rasgrp2 Flnb Jund Rasa1 Stmn1 Il1b Cdc25b Nlk Stk4 Map4k3 Tgfb2 Tgfb3 Nf1 Hspb1 Tmem97 Ppp3cc Ppp3cb Map4k2 Map4k1 Rasgrf2 Tab2 Daxx Ppp5c Pla2g4b Traf6 Pla2g4e Mapk1 Pla2g4d Fgf2 Nfkb2 Fgf1 Traf2 Fgf4 Akt3 Nfatc1 Mapk3 Akt2 Mapt Fgf3 Nfatc3 Akt1 Rap1a Fgf6 Prkacb Fgf5 Ngf Fgf8 Rps6ka3 Fgf7 Rps6ka4 Fgf9 Cacna2d1 Cacna2d3 Cacna2d4 Egfr Dusp16 Ppm1b Nras Ptpn7 Map2k6 Ptpn5 Dusp3 Raf1 Ntf4 Dusp2 Hspa1l Dusp4 Ntf3 Arrb2 Arrb1 Dusp10 Dusp9 Dusp8 Cacnb4 Cacnb1 Pdgfrb Mapkapk2 Cacnb2 Taok2 Rras2 Taok1 Taok3 Mapkapk5 Ntrk2 Ntrk1 Rapgef2 Mapk8ip1 Mapk9 Mapk8ip3 Atf2 Il1r2 Fgfr3 Ikbkb Mknk1 Mapk8 Chuk Map3k11 Ikbkg Tgfbr1 Elk1 Fgfr4 Map3k14 Fgfr1 Fgfr2 Prkaca Cd14 Fgf16 Fos Rela Fgf17 Fgf14 Fgf18 Fgf19 Map3k1 Braf Fgf12 Fgf13 Map2k7 Fgf10 Fgf11 Mapk13 Rac1 Map2k4 Grb2 Fgf20 Rras Mapk10 Sos2 Crk Sos1 Gna12 Pak1 Pak2 Tnfrsf1a Cdc42 Nfkb1 Faslg Pla2g4a Egf Mos Crkl Map2k1 Prkcd Mapk14 Hras Bdnf TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260710%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Ifng Cxcl10 Jak1 Il1b Spi1 Jak2 Socs3 Eif2ak2 Cxcl9 Ifnb1 Ifngr2 Oas1a Prkcd Ifngr1 Reg1 Psmb9 Gbp1 Hist1h4m Tap1 Ptpn11 Ciita Nos2 Irf4 Cybb Irf1 Irf2 Irf8 Isg15 Irf9 Ifit2 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260710%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Gal3st3 Nat9 Cyp17a1 Inmt Cyp2e1 Cyp1a1 Akr7a3 Akr7a2 Ephx1 Cyp2f2 Cyp7b1 Akr1b1 Chst10 Chst12 Sult2b1 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Sult6b2 Gstk1 Naa40 Ugt2b1 Gsto1 Nat10 Mgst1 Ndst1 Cyp4x1 Ndst3 Hnmt Hs3st3a1 Sult4a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Cyp24a1 Chst9 Akr1c1 Gstp1 Cyp7a1 Zfp628 Gstz1 Hs3st2 Sult1b1 Hs3st5 Hs3st6 Cyp2s1 Hs3st3b1 Gstm7 Cyp4f39 Baat Gstm5 Gstm4 Cyp27b1 Naa20 Akr1d1 Gstcd Kcnab2 Cyp51a1 Sult1e1 Glyat Gstm1 Cyp8b1 Comt Kcnab3 Hs2st1 Sult1a1 Cyp26b1 Tpmt Cyp1b1 Gss Fmo1 Fmo3 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Naa50 Cyp26a1 Akr1b10 Chst11 Cyp26c1 Cyp46a1 Nat8 Nat1 Cyp21a1 Nat2 Ephx2 Gal3st4 Akr1a1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP1284%RATTUS NORVEGICUS EPO receptor signaling Sos1 Ptprc Jak2 Src Stat3 Map2k2 Ptpru Raf1 Irs2 Epo Shc1 Pdk1 Mapk1 Stat5a Stat5b Mapk3 Pik3cg Akt1 Map2k1 Grb2 Rasa1 GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260710%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Cyp11a1 Cyp17a1 Akr1c9 Hsd11b1 Hsd11b2 Cyp21a1 POLYOL PATHWAY%WIKIPATHWAYS_20260710%WP1303%RATTUS NORVEGICUS Polyol pathway Sord Aldob Khk Akr1b1 BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260710%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Plg Mapk1 Ngfr Raf1 Ntrk2 Map2k1 Bdnf Serpine1 Plat GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260710%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Hcar1 Adra2a Ghsr Adra2c Adra2b Gpr161 Npy1r Rrh Htr4 Adora2a Or3a1 Htr6 Cxcr1 Oprd1 Ednra Or2h2 Gpr65 Or2h1 Ntsr1 Gpr68 Htr7 Cxcr4 Gpr63 Fshr Oprl1 Adrb1 Htr2a Gpr173 Adra1b Gpr174 Ccr5 Adra1a Ccr2 Adrb3 Galr2 Adra1d Gpr171 Cckbr Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr2 Sstr4 Sstr3 Htr1f Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Htr5a Tbxa2r C5ar2 Or7c70 F2r Ffar3 Or3a1e Fpr1 Aplnr Chrm3 Nmbr Ptgfr Fpr3 Chrm2 Ffar1 Bdkrb1 Fpr2 Or2f1 Ffar2 Ccr10 Drd3 Hrh1 Drd4 Or2b2 Or2j3 Cnr1 Hrh2 Gpr18 Hrh3 Grpr Or5v1b Gpr85 P2ry13 Or7a36 Gpr17 Drd5 Opn4 Lpar6 Oxtr Adora2b Xcr1 Lpar5 Opn3 Olr1073 Gper1 Gpr19 Sucnr1 Or6b1 Gpr15 Or2c1 Or13c7d Adora1 Gpr12 Adora3 Or2t1 Cckar Opn1sw Npbwr1 Ednrb Nmur2 Prlhr Npy5r Ntsr2 Ptgdr Brs3 Gpr25 Ptger4 Mc2r Ptger2 Gpr27 Ptger3 Gpr22 Gpr21 Ptger1 Ccr9 Agtr2 Bdkrb2 Mchr1 Ccr7 Htr2c Ccr6 Lpar4 Ccr3 Mtnr1a Npy4r Gpr37 Gpr39 Htr1d Or11a4 Htr1a Rgr Or14j1 Mc4r P2ry6 Or10j27 Ptafr Npffr1 P2ry2 Or2f2 Npffr2 Drd1 P2ry1 Ptgdr2 Rho Hcrtr1 Or5ap2b Or2w1 Gpr37l1 Cysltr2 Cysltr1 Npy2r Ackr4 Gpr4 Cnr2 Gpr3 Ackr2 Gpr6 P2ry10 Chrm1 Mc3r Or2ag1 Chrm5 P2ry12 Chrm4 P2ry14 F2rl1 Or10a4 Gpr50 Oprk1 F2rl2 F2rl3 Agtr1 Ptgir Mas1 C3ar1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260710%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Cyp2e1 Cyp24a1 Cyp7a1 Nr1i3 Nr1i2 Abcb1a Abcd2 Abcd3 Cyp2c11 Abcb4 Rara Cyp4b1 Rarb Cyp2b2 Vdr Ppard Abcg1 Cyp27b1 Ppara Abca1 Pparg Abcc3 Abcg5 Abcc2 Abcb11 Cyp8b1 Nr1h3 Cyp26a1 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Src Ptpru Raf1 Stat5a Prkca Stat5b Pik3cg Jak2 Stap1 Mitf Grb10 Socs5 Socs4 Matk Socs6 Csf2rb Shc1 Cltc Sh3kbp1 Plcg1 Cblb Vav2 Fgr Dok1 Kit Tnfrsf10b Grb2 Spred1 Mpdz Spred2 Grb7 Abl1 Fyn Pik3r1 Grap Crk Bad Sos1 Plce1 Pik3r2 Tec Fes Stat3 Crkl Map2k1 Rasa1 Hck Prkcb Rps6ka1 Btk Ptpn6 Ptpn11 Lyn Mapk1 Sh2b2 Hras Akt1 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP40%RATTUS NORVEGICUS Inflammatory response pathway Ifng Col1a2 Cd86 Cd40 Il4r Cd80 Il5ra Cxhxorf65 Il2ra Il2rb Tnfrsf1b Lama5 Il5 Vtn Il2rg Tnfrsf1a Lck Col1a1 Cd40lg Lamc1 Lamb1 Thbs1 Il2 Il4 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260710%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Cebpb Prkca Aimp2 Maf Gclm Hmox1 Nfe2l2 Nqo1 Ephb2 Mapk8 RETINOL METABOLISM%WIKIPATHWAYS_20260710%WP1297%RATTUS NORVEGICUS Retinol metabolism Lpl Adh4 Aldh1a1 Adh1 Cyp2e1 Adh5 Dhrs3 Cd36l1 Rdh12 Aldh1a3 Rara Rdh10 Rarb Bco1 Npc1l1 Rpe65 Rxrb Rbp7 Abcg8 Abcg5 Rbp4 Scarb1 Retsat Crabp2 Cd36 Lrat Rlbp1 Sult1a1 Cyp26b1 Rxra Cyp26a1 Sult2b1 Rxrg PROTEASOME DEGRADATION%WIKIPATHWAYS_20260710%WP302%RATTUS NORVEGICUS Proteasome degradation Psmb7 Psmd8 Uchl1 Psmb1 Psmd3 Psmd2 Psmd5 Psmd4 Psmb2 Ube2d3 Ube2d1 Psmb9 Psmc6 Psmc5 Psma5 Psmc2 Rpn2 Psma2 Psmc4 Psmc3 Rpn1 Psme2 Psme1 Psmd12 Psmd11 Ube2b Psmd13 Uchl3 Psmb8 Psmb6l1 Psmb5 Psmd6 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260710%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Map3k14 Ifnb1 Map3k7 Rela Pdlim7 Ccl5 Tradd Traf6 Mapk1 Nfkb1 Nfkb2 Ikbkb Mapk8 Chuk MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260710%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Gja1 Il6 Nos1 Prkd1 Ets2 Rgs4 Rgs5 Rgs2 Rgs3 Prkca Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Rgs7 Plcg2 Myl4 Mylk2 Prkch Myl2 Rxfp2 Atf5 Atf3 Maff Pkib Calca Grk5 Grk4 Atf6b Gnaq Pkia Grk6 Prkcz Rxfp1 Pkig Gngt1 Gucy1a1 Dgkz Gnb2 Gnb1 Gnb4 Gnb3 Rln1 Gng13 Ryr2 Atp2a3 Atp2a2 Ywhaq Oxt Adm Ywhah Ywhag Gabpa Ywhae Ywhab Adcy3 Adcy4 Adcy2 Guca2b Adcy7 Guca2a Oxtr Crhr1 Adcy5 Lpar1 Creb3 Adcy9 Cald1 Pde4b Crh Acta1 Prkar1a Jun Prkar1b Rgs20 Camk2g Prkcg Rgs17 Camk2d Igfbp3 Gng3 Rgs19 Gng2 Igfbp4 Vkorc1l1 Camk2a Rgs14 Gng7 Il1b Igfbp1 Rgs16 Pde4d Gng8 Nos3 Actc1 Prkar2b Rgs10 Ackr5 Corin Ramp3 Plcb3 Prkacb Camk2b Prkce Actb Arrb2 Arrb1 Actg1 Atf2 Prkcq Fos Plcg1 Itpr3 Itpr1 Gsto1 Nfkb1 Prkcb Prkcd NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260710%WP146%RATTUS NORVEGICUS Nucleotide metabolism Polg Adss2 Sat1 Srm Dhfr Pold1 Prps2 Polb Impdh1 Nme2 Mthfd2 Hprt1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260710%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2a Adora1 P2ry6 Lpar6 Adora2b P2ry2 Lpar4 P2ry1 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Socs3 Stat3 Irs2 Cxhxorf65 Ptpn11 Shc1 Il2rg Mapk1 Stat5a Vcp Stat5b Mapk3 Kat5 Il9 Akt1 Jak3 Map2k1 Grb2 Il9r Jak1 Pik3r1 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260710%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Scnn1b Scnn1g Cftr Nherf1 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Map2k6 Map3k7 Map3k5 Tradd Ripk1 Cdc42 Mapkapk2 Pla2g4a Mapkapk5 Atf2 Mknk1 Tgfbr1 Elk1 Tgfb2 Hspb1 Daxx Map3k1 Shc1 Mef2d Mapk14 Traf2 Rac1 Map2k4 Hras Grb2 Max Map3k9 Rps6ka5 CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260710%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Rack1 Nherf2 Prkaa2 Snap23 Pdzk1 Ezr Prkaca Plcb3 Plcb2 Plcb1 Prkcg Cftr Ppp2ca Plcz1 Nherf1 TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Map2k6 Il6 Il12b Il12a Ticam2 Lbp Ly96 Tlr1 Ifna4 Irf3 Ccl5 Ifna1 Irf7 Tlr8 Irf5 Tlr7 Tlr6 Tlr5 Tlr4 Tlr3 Tlr2 Pik3cg Cxcl11 Cxcl10 Ifnar1 Ccl4 Pik3cd Ccl3 Pik3ca Spp1 Mapk9 Tollip Map2k3 Ikbkb Mapk8 Chuk Ikbkg Cxcl9 Ifnb1 Cd14 Fos Rela Map2k7 Mapk13 Rac1 Map2k4 Mapk10 Pik3r5 Pik3r1 Pik3r2 Pik3r3 Cd86 Map3k8 Cd40 Map3k7 Cd80 Ripk1 Jun Nfkb1 Fadd Map2k1 Il1b Tnf Tab2 Traf6 Mapk14 Mapk1 Nfkb2 Nfkbia Akt3 Mapk3 Akt2 Akt1 ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260710%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Arrb2 Prkcg Prkca Plcg2 Calm3 Calm2 Pdpk1 Pde2a Nos3 Pten Agtr1b Dnm1 Agtrap Agtr2 Agtr1 Prkaca Gnaq Plcg1 Akt3 Akt2 Nox4 Akt1 Mas1 Itpr3 Itpr2 Itpr1 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260710%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Jun Nfkb1 Nfe2l2 Gpx6 Msrb1 Selenow Selenbp1 Txnrd2 Rpl30 Eefsec Crem Sp3 Fos Selenof Rela Sars2 Selenoi Sars1 Selenok Fabp1 Gpx3 Selenoo Selenop Selenos Dio1 Selenot Dio2 Dio3 Selenov Sephs1 Trnau1ap OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260710%WP173%RATTUS NORVEGICUS Oxidative stress response Sod1 Txnrd2 Mgst1 Cat Fos Cyp1a1 Nqo1 Xdh Gpx3 Mapk14 Nfkb1 Gstt2 Hmox1 Nfix Sod3 Sod2 Txn2 Mapk10 Cyba Junb ESTROGEN SIGNALING%WIKIPATHWAYS_20260710%WP1279%RATTUS NORVEGICUS Estrogen signaling Src Mapk9 Ikbkb Chuk Elk1 Prkaca Fos Braf Gngt1 Ccnd1 Gnb1 Grb2 Ilk Mnat1 Hdac3 Hdac2 Sos1 Hdac5 Taf13 Hdac1 Taf12 Gtf2f2 Tbp Ccnh Gtf2b Gtf2e1 Polr2c Polr2a Gper1 Polr2b Taf9 Polr2g Polr2h Jun Nfkb1 Polr2f Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Ercc3 Map2k1 Esr1 Crebbp Cdk7 Brca1 Taf7 Taf6 Taf5 Shc2 Mapk14 Mapk1 Hras Akt1 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Ikbkg Cd40 Map3k7 Ephb2 Rela Ikbkb Mapk8 Chuk BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260710%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Eci1 Hadha Decr1 Hadhb Acadm AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260710%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Glyat SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260710%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Nlgn1 Htr1a Arc Plek Prkcb Htr2c Fos Htr2a Ppp3ca Adra1a Crh Grin2d HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260710%WP1296%RATTUS NORVEGICUS Homologous recombination Pold2 Rad51 Rad50 Brca2 Rad52 Pold1 Pold4 Pold3 Fsbp Nbn TRANSLATION FACTORS%WIKIPATHWAYS_20260710%WP149%RATTUS NORVEGICUS Translation factors Eif2b2 Eif2b5 Eif2b4 Kcnq2 Eif2s2 Eef2k Eif2b1 Eif4h Eif4e Eif1 Eif1ax Eif6 Eif4a2 Eif4a1 Etf1 Gspt2 Cluh Eif2ak2 Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif3f Eif4ebp1 Eif4g1 Eif2ak3 Eif4g3 Eif3b Eif3a Eif1a Eif5b Eif5a Eif2b3 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Rack1 Src Raf1 Vcl Pxn Mapk7 Mapkapk2 Birc5 Stat5a Bcl2l11 Prkca Kcnip3 Stat5b Rac2 Slc2a1 Fcer2 Mmp2 Pik3cd Gab1 Pik3ca Bcl2l1 Mapk9 Gab2 Atf2 Chek1 Rara Il3ra Mapk8 Il3 Foxo1 Selp Rps6kb2 Ptk2 Id1 Bmx Spi1 Jak2 Dnm1 Prkaca Matk Csf2rb Shc1 Rac1 Grb2 Ywhaq Fyn Pik3r1 Ywhab Crk Bad Sos1 Pik3r2 Tec Fes Stat3 Pak1 Tnfrsf1b Lck Cdc42 Nfkb1 Syk Crkl Map2k1 Mmp9 Jak1 Gsk3b Hck Socs3 Gsk3a Prkcb Hspb1 Ptpn6 Ptpn11 Lyn Mapk14 Mapk1 Rapgef1 Bax Mapk3 Rxra Hras Akt1 Rap1a Ppp2ca Gata2 MONOAMINE GPCRS%WIKIPATHWAYS_20260710%WP276%RATTUS NORVEGICUS Monoamine GPCRs Drd5 Adra2a Adra2c Adra2b Chrm1 Htr4 Chrm5 Chrm4 Htr6 Htr7 Htr2a Adrb1 Adra1b Adra1a Adrb3 Adra1d Htr5b Htr2c Htr1f Htr1d Htr5a Htr1a Chrm3 Chrm2 Drd3 Hrh1 Drd1 Drd4 Hrh2 P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260710%WP656%RATTUS NORVEGICUS p53 signal pathway Ccnb3 Gadd45g Ccne1 Fas Gtse1 Bbc3 Siah1 Casp9 Perp Pmaip1 Parp1 Rprm Tp53 Casp3 Bax Bid Igfbp3 Cdk1 Igf1 Mdm2 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Crk Sos1 Src Stat3 Map2k2 Raf1 Dock1 Pak1 Pxn Jun Itga1 Crkl Map2k1 Pik3ca Gab1 Rasa1 Mapk8 Ptk2 Elk1 Pten Fos Map4k1 Rap1b Ptpn11 Hgf Itgb1 Met Mapk1 Rapgef1 Mapk3 Ptk2b Hras Rap1a Grb2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260710%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Ppp3ca Prkar1b Tfb1m Tfb2m Mterf1 Camk4 Nrf1 Ppargc1b Myef2 Esrra Ppargc1a Gabpb2 Tfam Pprc1 Gabpa RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260710%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Mapk8 Gpi Eno1 Pgam2 Gapdh Pklr Aldoa Pfkl Pgk1 Ftl1 Nnt Fth1 Pgm2 Ugdh Pgm1 Ptgr1 Kif1b Pgd Abcc1 Tfr2 Fas Tkt Cdkn1a Gapdhl6 Rpe Taldo1 Dpep2 Map3k5 Txn Rpia Ugp2 Tp53 Ugt8 Ltc4s Tfrc Gck Pgls Casp3 Dffa Gstp1 Gsn Dffb Alox5 Nqo1 Gss Anpep G6pdx Bax Gclm PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260710%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Pgls Kif1b G6pdx Pgd Tkt Rpe Taldo1 Rpia WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260710%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Dvl1 Prkca Mapk9 Ppard Prkcq Prkcz Ccnd1 Rhoa Mapk10 Map3k7 Tp53 Jun Pafah1b1 Ppp2r3a Ctnnb1 Sox2 Ppp2r2c Ppp2r2b Apc Ctbp1 Crebbp Wnt5a Ctbp2 Wnt9b Ppp2cb Nlk Prkci Ptpa Gsk3b Axin1 Axin2 Fbxw2 Prkcb Lef1 Wnt11 Tmem97 Tcf7 Prkcd Lrp6 Nkd2 Lrp5 Wnt6 Wnt3a Dvl2 Dvl3 Wnt7a Wnt5b Wnt2 Plau Tcf7l1 Wnt4 Cd44 Wnt3 Pou5f1 Fosl1 Fzd3 Ccnd2 Fzd2 Fzd4 Fzd9 Prkce Fzd8 Nanog Ppp2r2a Ppp2ca Ppp2r1a Ppm1j VEGFR 3 SIGNALING%WIKIPATHWAYS_20260710%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Bad Itpkc Nos3 Flt4 Vegfd Vegfc Casp9 Shc1 Mapk1 Plcg1 Mapk3 Pik3cg Akt1 Grb2 TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260710%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Ikbkg Sos1 Il6 Tgfa Muc2 Raf1 Ripk2 Rps6ka2 Tnf Rela Tradd Shc1 Tnfrsf1a Mapk1 Nfkb1 Nfkbia Traf2 Tlr4 Map2k1 Grb2 Ikbkb Chuk Egfr ID SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP397%RATTUS NORVEGICUS ID signaling pathway Id3 Psmd4 Myog Ccna2 Srebf1 Myod1 Id2 Kdr Id4 Elk4 Hes1 Tcf7l2 Bmp6 Lck Cd40lg Nfkb1 Pax2 Smad1 Bmp2 Smad4 Pax8 Tert Egf Smad5 Igf1 Igf1r Myf5 Id1 Elk1 Atf3 Ccne1 Rbl2 Rbl1 Rela Rb1 Ngf PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260710%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Ca2 Nherf2 Ca4 Slc22a8 Atp6v1d Ca14 Atp6v1h Slc20a2 Slc22a6 Car15 Slc26a1 Atp1a1 Fxyd4 Slc22a5 Nherf1 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1e1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc34a1 Slc6a19 Slc7a6 Slc7a7 Atp1b1 Slc9a3 Slc9a8 Slc13a3 Slc7a8 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Slc13a2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260710%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Ndufab1 Ndufc1 Coxfa4 Ndufc2 Ndufa5 Gzmb Atp5pb Gzmc Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Mt-nd3 Mt-nd4l Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 MISMATCH REPAIR%WIKIPATHWAYS_20260710%WP1295%RATTUS NORVEGICUS Mismatch repair Rfc1 Pold1 Lig1 Pcna Msh2 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Map3k7 Nfkb1 Map2k1 Tollip Il1r2 Il1b Mapk8 Chuk Map3k14 Rela Prkcz Ptpn11 Traf6 Mapk1 Il1rap Peli1 Plcg1 Nfkbia Sqstm1 Il1a Irak4 Mapk3 Irak3 Nfkbib Akt1 Irak2 Capn1 Il1r1 Elp1 Sirpa Capns1 Tab1 Il1rn CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260710%WP632%RATTUS NORVEGICUS Cholesterol metabolism Mvk Rusc1 Lpl Apoc1 Apoc2 Dhcr7 Fdft1 Lss Scarb1 Hmgcs1 Hmgcr Apoe Srebf1 Mvd Msmo1 Soat1 Fdps Idi1 ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260710%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast GLYCOGEN METABOLISM%WIKIPATHWAYS_20260710%WP160%RATTUS NORVEGICUS Glycogen metabolism Pgm1 Gbe1 Ugp2 Phkb Ppp2r5b Ppp2r5a Gys1 Gys2 Phka1 Phka2 Gyg1 Ppp2r3a Pygb Phkg1 Ppp2r2c Phkg2 Ppp2r2b Agl Calm3 Calm2 Ppp2cb Ptpa Gsk3b Gsk3a Ppp2r2a Ppp2ca Ppp2r1a SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260710%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Cyp1a1 Msra Msrb2 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260710%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Kcnk12 Ca2 Ca4 Kcnq1 Slc12a7 Kcnj16 Clcnkb Clcnka Atp1b1 Slc9a3 Slc4a7 Slc12a1 Atp1a1 Slc9a2 Aqp1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260710%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Map2k6 Il6 Map2k2 Raf1 Rps6ka2 Eif4e Pxn Ppp2r5b Ppp2r5a Mapkapk2 Stat5a Stat5b Hnf1a Gab1 Gab2 Mapk8 Foxo1 Ptk2 Bmx Jak2 Fos Erbb2 Il6st Ppp2r3b Hsp90aa1 Foxo4 Cdk5r1 Sgk1 Shc1 Ppp2r5c Cebpb Rps6kb1 Il6r Plcg1 Inppl1 Ncoa1 Cdk9 Rb1 Ppp2r5e Rac1 Fgr Ptk2b Cdk5 Map2k4 Grb2 Fyn Pik3r1 Bad Sos1 Pik3r2 Tec Fes Stat3 Hdac1 Cd40 Map3k7 Casp9 Map3k4 Jun Nfkb1 Casp3 Ppp2r3a Ppp2r2c Map2k1 Ppp2r2b Crebbp Foxo3 Jak1 Ppp2cb Nlk Ptpa Gsk3b Hck Socs3 Hspb1 Tmem97 Prkcd Btk Daxx Ptpn11 Lyn Mapk14 Mapk1 Mapk3 Mapt Eif4ebp1 Hras Akt1 Ppp2r2a Ppp2ca Ppp2r1a FOCAL ADHESION%WIKIPATHWAYS_20260710%WP188%RATTUS NORVEGICUS Focal adhesion Src Map2k2 Mapk7 Rac2 Mylk2 Erbb2 Rap1b Hgf Ccnd1 Itgb1 Met Tnc Comp Rock2 Ppp1r12a Tnn Tnr Col5a1 Pgf Reln Lama3 Lama4 Tln1 Thbs2 Thbs4 Blk Vasp Shc3 Srms Txk Chad Itga8 Itga6 Itga9 Pdgfa Itga3 Pdgfb Itga10 Cav3 Jun Cav2 Col1a1 Cav1 Tesk2 Tnk2 Col4a1 Col4a2 Ptk6 Col4a6 Igf1 Ibsp Pelo Itgax Itgav Itgae Itgal Diaph1 Itgad Itgb8 Itgb6 Itga2b Itgb5 Actn1 Itgb3 Col11a1 Col11a2 Lamb3 Vegfb Col6a2 Styk1 Zyx Pip5k1c Mapk12 Mapk1 Akt3 Akt2 Mapk4 Akt1 Ccnd2 Rap1a Egfr Actb Map2k6 Vegfd Vegfc Raf1 Vcl Pxn Kdr Pdgfrb Pdgfra Pik3cg Actg1 Igf1r Pik3cd Pik3ca Spp1 Mapk9 Map2k3 Mapk8 Ptk2 Pdpk1 Elk1 Pten Mylk Braf Shc1 Selenop Rac1 Fgr Grb2 Pik3r5 Ilk Fyn Pik3r1 Crk Bad Sos1 Pik3r2 Col1a2 Dock1 Bcar1 Pak1 Pak6 Pak3 Lama5 Pak2 Vtn Pak5 Pak4 Vwf Cdc42 Lamc1 Lamb1 Thbs1 Egf Map2k1 Itgam Rock1 Gsk3b Hck Itgb2 Mapk14 Rapgef1 Hras Capn1 STATIN PATHWAY%WIKIPATHWAYS_20260710%WP145%RATTUS NORVEGICUS Statin pathway Lpl Apoc1 Abca1 Cyp7a1 Scarb1 Hmgcr Apoe Mttp Soat1 Lcat STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260710%WP316%RATTUS NORVEGICUS Striated muscle contraction Actn4 Myl9 Actc1 Tnnt3 Acta1 Acta2 Tnnt2 Tnnt1 Tpm4 Tpm3 Tpm2 Neb Tnni3 Actg1 Tnni2 Tnni1 Vim Tnnc2 Tnnc1 Tmod1 Myh3 Actn3 Myl2 Mybpc3 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP517%RATTUS NORVEGICUS Notch signaling pathway Aph1a Ncstn Dtx2 Hdac1 Dtx3 Dtx4 Dvl1 Dll3 Rbpjl Maml1 Dll4 Mfng Numb Hes5 Jag2 Hes1 Jag1 Kat2a Rfng Numbl Notch1 Notch2 Lfng Notch3 Psen1 Psen2 Ctbp1 Crebbp Ctbp2 Dvl2 Dvl3 TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Src Psmd3 Tradd Gab1 Kcnq1 Prkcz Rps6kb1 Ywhah Ywhag Ywhae Ywhab Map3k8 Cav1 Map3k2 Casp3 Flna Hspb1 Tab2 Traf6 Nfkb2 Traf2 Akt2 Akt1 Ppp2ca Rack1 Ripk2 Nkiras1 Nr2c2 Nkiras2 Tbkbp1 Rps11 Rpl6 Ikbkb Rps13 Chuk Pias3 Ptk2 Fbl Ikbkg Ube2i Map3k14 Dpf2 Polr1b Rnf216 Rpl30 Polr1a Polr1g Prkaca Fbxw11 Polr1e Casp8ap2 Rela Txlna Tank Gtf2i Map3k3 Map3k1 Actl6a Smarce1 Tifa Ube2d2 Polr2sl1 Btrc Nfkbiz Glg1 Bag4 Ripk3 G3bp2 Dcaf7 Cops3 Capn3 Kpna6 Mcc Kpna3 Kpna2 Dap Cul1 Hdac2 Rel Ccar2 Traf4 Hdac1 Mcm7 Pfdn2 Faf1 Csnk2a1 Casp7 Tnfrsf8 Mark2 Smarcb1 Tnfrsf1b Alpl Rasal2 Akap8 Casp2 Ripk1 Csnk2b Tnfrsf1a Rpl8l1 Nfkb1 Cyld Fkbp5 Fadd Mcm5 Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Crebbp Trpc4ap Fancd2 Ktn1 Pebp1 Pkn1 Lrpprc Mtif2 Gsk3b Tnf Ptpn11 Psmc2 Nfkbia Psmc3 Nfkbib Psmd12 Elp1 Psmd13 Psmb5 Psmd6 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP375%RATTUS NORVEGICUS Wnt signaling pathway Raf1 Dvl1 Sox9 Arrb2 Arrb1 Pax2 Prkca Smad4 Mapk8ip1 Mapk9 Mapk8 Ccnd1 Rhoa Btrc Rac1 Cdk1 Cul1 Map3k7 Tbp Csnk2a1 Mark2 Csnk2b Jun Camk2g Prkcg Camk2d Ctnnb1 Apc Ctbp1 Wnt5a Camk2a Ctbp2 Nlk Cdh1 Gsk3b Axin1 Tax1bp3 Axin2 Skp1 Sfrp2 Prkcb Lef1 Sfrp1 Tmem97 Dkk1 Magi3 Lrp6 Ror2 Crybb2 Lrp5 Csnk1d Sall1 Wnt3a Cdc25c Dvl2 Senp2 Dvl3 Ruvbl1 Wnt7a Vangl2 Wnt2 Csnk1a1 Mapk1 Dab2 Wnt4 Tfap2a Brd7 Wnt3 Jup Mapk3 Map1b Ctnnbip1 Akt1 Ankrd6 Camk2b Fzd2 Bcl9 Fzd4 Dlg1 Fzd9 Dlg2 Fzd8 Dlg4 Tcf4 Nr5a1 Ppp2ca Hipk2 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260710%WP124%RATTUS NORVEGICUS Irinotecan pathway Ces1f Ces1e Ces1d Ces2c Abcc1 Abcg2 Abcc2 Bche OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260710%WP227%RATTUS NORVEGICUS Osteoblast signaling Col1a1 Pdgfrb Pdgfra Bglap Pth Tnfsf11 Fgf23 Slc34a1 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260710%WP161%RATTUS NORVEGICUS Small ligand GPCRs Ptger2 Ptger3 Ptger1 Cnr2 Lpar1 Mtnr1a Ptgir Ptgfr Ptafr S1pr3 S1pr1 Cnr1 Ptgdr Ptger4 INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260710%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Bad Sos1 Raf1 Rptor Eif4e Mtor Pfkfb2 Rheb Foxk1 Akt1s1 Rps6 Tsc2 Tsc1 Gys1 Mlst8 Gys2 Acly Foxo1 Gsk3a Rps6ka1 Irs2 Grb10 Ins1 Shc1 Pik3c3 Rps6kb1 Mapk1 Mapk3 Eif4ebp1 Akt1 Grb2 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260710%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Ache Pcyt1a Pdha1 Ahsg Chat Pemt GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260710%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Glp2r Vipr1 Calcrl Adgrl2 Glp1r Adgrl3 Crhr2 Crhr1 Ghrhr Calcr Adgre5 Gipr Gcgr Adgre1 Sctr Adgrl4 Adcyap1r1 Adgrl1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260710%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Tnf Mmp15 Mmp16 Mmp28 Timp3 Timp2 Timp4 Bsg Tcf20 Mmp21 Mmp2 Mmp9 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Rack1 Nr3c1 Raf1 Eif4e Mtor Ets2 Mapkapk2 Stat5a Stat5b Tert Pik3cg Pik3cd Pik3ca Mapk9 Gab2 Il2 Mknk1 Mapk8 Chuk Jak2 Ybx1 Rela Prkcz Shc1 Rps6kb1 Stam2 Cd53 Itm2b Ptk2b Stam Nmi Grb2 Fyn Pik3r1 Crk Sos1 Pik3r2 Stat3 Cxhxorf65 Il2ra Il2rg Lck Nfkb1 Syk Crkl Map2k1 Foxo3 Jak1 Socs3 Irs2 Ptpn6 Ptpn11 Lyn Mapk14 Mapk1 Plcb1 Mapk3 Akt1 Jak3 Eif3b GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260710%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Tgfb2 Tgfb1 E2f1 Ccne1 Raf1 Cdkn1a Erbb2 Ccnd1 Tp53 Mapk1 Smad4 Rb1 Akt1 Dmp1 Map2k1 Pik3cd Pik3ca Mycb Mdm2 Crebbp Rasl11b Smad2 Necab3 Egfr BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260710%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Cyp17a1 Hsd3b6 Cyp21a1 WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260710%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Pparg Wnt3a HYPERTROPHY MODEL%WIKIPATHWAYS_20260710%WP442%RATTUS NORVEGICUS Hypertrophy model Ifrd1 Ccn1 Atf3 Nr4a3 Ifng Myog Eif4e Il1a Eif4ebp1 Ankrd1 Il1r1 Jund Wdr1 Hbegf Zeb1 Dusp14l1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260710%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Pon3 Ces5a Pon1 Pon2 Ces2j Esd Lipa VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260710%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Bad Nos3 Src Vegfc Pik3r3 Raf1 Vegfb Sh2d2a Casp9 Hspbp1 Pxn Shc1 Mapkapk2 Mapk1 Plcg1 Prkca Rac1 Akt1 Grb2 Pgf Prkci CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260710%WP590%RATTUS NORVEGICUS Cardiovascular signaling Thbs2 Map2k6 Vegfd Arhgef7 Casp6 Capn6 Hspa1b Casp2 Vwf Col1a1 Pdgfra Casp3 Rras2 Col4a1 Col4a2 Wasf1 Egf Stmn1 Mapk8 Hspb1 Col11a1 Erbb2 Wnt2 Selenop Vav2 Tnc Akt1 Col5a1 Pgf Cfl1 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260710%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Psme3 G6pc1 Slc5a10 Hk1 Sord Khk Naglt1 Akr1b1 Tpi1 Slc2a5 Tkfc Fbp1 Aldob Aldoa Pfkl Pfkp Slc5a9 Gpi INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260710%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Map2k6 Src Map2k2 Raf1 Vcl Arhgef7 Pxn Mapk7 Itga1 Rac2 Mylk2 Map2k3 Pdpk1 Ptk2 Braf Rap1b Selenop Itgb1 Shc1 Vav2 Rac1 Rock2 Grb2 Capn3 Mapk10 Ilk Fyn Tln1 Crk Sos1 Pik3r2 Vasp Shc3 Dock1 Bcar1 Itga8 Pak1 Itga6 Pak6 Itga9 Capn6 Itga3 Pak3 Vav3 Pak2 Itgb4 Itga10 Itga2 Pak4 Cav3 Cdc42 Capn9 Cav2 Git2 Cav1 Capn5 Capn7 Capn2 Map2k1 Itgax Itgam Itgav Itgae Rock1 Itgal Itgad Itgb8 Itgb6 Itga2b Itgb5 Itgb3 Itgb2 Zyx Mapk12 Mapk1 Rapgef1 Akt3 Akt2 Hras Mapk4 Akt1 Rap1a Capn1 Capns1 Rho NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Dhcr7 Mapk7 Prkca Slc2a1 Prkcz Ftl1 Fth1 Ugdh Abcc1 Cdkn1a Map3k7 Taldo1 Txn Tp53 Acta1 Jun Prkcg Prkd3 Ube2k Herpud1 Prdx1 Abcc4 Pmf1 Mafg Ubb Slc1a4 Mafk Prkci Actg2 Bach1 Slc35b1 Dnajc5 Actc1 Aldh3a1 Sod1 Xpo1 Gsto2 Mgst2 Cbr1 Pik3r6 Dnajb4 Nqo1 Gstm1 Nqo2 Usp14 Ran Acta2 Mapk1 Vcp Mapk3 Fosl1 Prkce Actb Nras Map2k6 Raf1 Akr7a3 Akr7a2 Ephx1 Rras2 Actg1 Pik3cd Pik3ca Pik3c2b Mapk9 Pik3c2a Mapk8 Pik3c2g Abcc3 Prkcq Map3k1 Pik3c3 Map2k7 Ldhb Aldoa Sod3 Sod2 Rras Pik3r5 Fyn Pik3r1 Gstk1 Pik3r2 Gsto1 Pik3r3 Mgst1 Gstp1 Hmox1 Nfe2l2 Map2k1 Crebbp Brca1 Gstm5 Gsk3b Gstm4 Prkcb Scarb1 Prkcd Psmc6 Psmc5 Gss Fmo1 Psmc2 Gstm6 Mapk14 Gstm3 Gstm2 Psmc4 Sqstm1 Psmc3 G6pdx Gstt2 Gstt1 Gclm Akr1b10 Hras Eif2ak3 Akr1a1 MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260710%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Neurod1 Sox6 Pdgfra Hes5 Zbtb18 Foxj3 Elovl7 INSULIN SIGNALING%WIKIPATHWAYS_20260710%WP439%RATTUS NORVEGICUS Insulin signaling Map2k2 Rptor Eif4e Mtor Rheb Tsc2 Tsc1 Gys1 Gys2 Prkca Gyg1 Rac2 Lipe Slc2a1 Gab1 Prkch Slc2a4 Rps6kb2 Foxo1 Prkcz Egr1 Sgk1 Rps6kb1 Inppl1 Shc3 Map3k8 Map3k7 Map3k6 Map3k5 Map3k4 Jun Map3k2 Prkci Map4k3 Map4k2 Map4k1 Mapk12 Mapk1 Cyth3 Grb14 Stxbp1 Mapk3 Stxbp2 Akt2 Stxbp3 Mapk4 Stxbp4 Akt1 Prkaa1 Kif5b Cblc Rps6ka3 Insr Rps6ka4 Map3k9 Flot2 Flot1 Rps6ka5 Map4k5 Rab4a Xbp1 Kif3a Prkaa2 Tbc1d4 Map2k6 Ehd1 Snap23 Ehd2 Raf1 Snap25 Arf1 Rhoj Rps6ka2 Ptprf Cap1 Rrad Inpp4a Ppp1r3a Vamp2 Rps6ka6 Mink1 Sgk3 Sgk2 Myo1c Enpp1 Ptpn1 Pik3cg Stx4 Arhgap33 Igf1r Map3k10 Pik3cd Mapk11 Mapk9 Pik3c2a Ikbkb Mapk8 Pik3c2g Pdpk1 Map3k11 Elk1 Pten Map3k14 Prkcq Fos Reg1 Grb10 Map3k3 Map3k1 Shc1 Pik3c3 Map2k7 Cblb Mapk13 Rac1 Map2k4 Grb2 Pfkl Mapk10 Sos2 Pik3r1 Crk Sos1 Pik3r2 Map2k1 Foxo3 Gsk3b Gsk3a Prkcb Rps6ka1 Trib3 Prkcd Irs2 Shc2 Ptpn11 Mapk14 Sh2b2 Rapgef1 Eif4ebp1 Hras GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260710%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Nr3c1 Anxa1 Nfkb1 Nfkbia Pla2g4a Tsc22d3 Hspa4 Mt-co2 Rras Fkbp4 ONE CARBON METABOLISM%WIKIPATHWAYS_20260710%WP1292%RATTUS NORVEGICUS One carbon metabolism Mtr Ftcd Ahcyl2 Bhmt Tcn2 Dnmt3a Aldh1l1 Shmt1 Mat1a Gart Dhfr Mthfr Mthfd2 Mthfd1l Ahcy Folh1 Mtrr APOPTOSIS%WIKIPATHWAYS_20260710%WP1290%RATTUS NORVEGICUS Apoptosis Irf3 Tradd Irf7 Irf5 Birc5 Bcl2l11 Igf1r Ikbkb Chuk Ikbkg Prf1 Hells Rela Traf1 Pmaip1 Bcl2l2 Xiap Map3k1 Bnip3l Lta Irf4 Irf6 Diablol1 Irf1 Bak1 Irf2 Tp73 Tnfrsf25 Igf2 Tp63 Map2k4 Tnfrsf10b Mapk10 Pik3r1 Bad Fas Casp7 Casp9 Tnfrsf1b Tp53 Casp2 Ripk1 Tnfrsf1a Jun Nfkb1 Fadd Casp3 Faslg Dffa Bid Dffb Nfkbia Traf2 Bax Nfkbib Akt1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260710%WP217%RATTUS NORVEGICUS Nuclear receptors Nr3c1 Esr2 Ror1 Nr5a2 Nr4a2 Nr1i3 Nr1i2 Nr2c2 Esr1 Rara Rarb Vdr Nr2f1 Ppard Rxrb Ppara Pparg Nr1h3 Rxra Nr2e1 Hnf4a Esrra Esrrb Nr2f6 Thrb Nr1d2 Thra Nr2f2 Rxrg Nr5a1 Rorc Nr1h2 P53 PATHWAY%WIKIPATHWAYS_20260710%WP655%RATTUS NORVEGICUS p53 pathway Sesn1 Chek2 Fas Zmat3 Cdkn1a Serpinb5 Cdkn2a Shisa5 Casp9 Sfnl1 Cycs Adgrb1 Ccnb1 Cd82 Tp53 Cdk6 Tsc2 Mdm4 Ppm1d Rchy1 Casp3 Bid Igfbp3 Ccng1 Chek1 Pten Ccne1 Siah1 Perp Pmaip1 Gadd45a Rprm Tp73 Bax Cdk1 Serpine1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260710%WP73%RATTUS NORVEGICUS G protein signaling pathways Nras Arhgef1 Prkca Slc9a1 Prkaca Prkcq Gnaq Prkcz Ppp3ca Gngt1 Gnb2 Gnb1 Rhoa Gnb3 Gng13 Rras Itpr1 Adcy3 Adcy4 Adcy2 Gna12 Adcy7 Gna13 Adcy5 Adcy9 Pde4b Akap8 Prkar1a Prkar1b Pde7b Pde7a Prkcg Akap7 Prkd3 Akap3 Akap4 Gng3 Akap1 Gnaz Akap10 Akap11 Akap12 Akap9 Akap13 Pde8a Pde8b Prkci Kcnj3 Pde4d Pakap Gng8 Gna14 Gnao1 Prkar2b Prkcb Gnal Gng5 Pde4c Ppp3cc Prkcd Gnas Pde1c Pde1a Gng11 Plcb3 Hras Prkacb Gnai1 Gnai3 Prkce Adcy8 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260710%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Prkcb Cyp2e1 Map2k1 Nfe2l2 Mafg Mapk8 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Smo Hhip Ccnb1 Gli1 Gli3 Gli2 Ski Shh Ptch2 Ptch1 Sufu Igf2 Sap18 Dyrk1a Cdk1 Crebbp ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Bad Crk Sos1 Src Tgfa Cdkn1a Mtor Pak4 Jun Stat5a Prkca Egf Map2k1 Gab1 Camk2a Mapk8 Ptk2 Elk1 Gsk3b Erbb2 Shc2 Map2k7 Rps6kb1 Mapk1 Plcg1 Akt3 Cdkn1b Eif4ebp1 Ereg Hras Nrg2 Nrg1 Grb2 Areg Cblc Btc Nrg4 Nrg3 Pik3r5 Hbegf Abl1 Egfr GLUCURONIDATION%WIKIPATHWAYS_20260710%WP1276%RATTUS NORVEGICUS Glucuronidation Ugt2b34 Pgm1 Ugt2a1 Ugt2b1 Hk1 Ugt2b7 Ugp2 Pgm2 Pgm5 Ugt2b35 Ugdh CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260710%WP513%RATTUS NORVEGICUS Catecholamine synthesis Ddc Th Pah Dbh Pnmt G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260710%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Ccna1 Ccne2 Cdkn2b Tfdp1 Cdkn2c Cldn5 Myt1 Mcm4 Mcm6 Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Creb3l1 Orc5 Rpa3l1 Orc4 Orc6 Orc1 Orc3 Mdm2 Rpa2 Necab3 Wee1 E2f3 E2f4 E2f6 Pole Cdkn1c Ccne1 Rbl1 Atf6b Gadd45a Ccnd1 Rb1 Cdk1 E2f5 Mnat1 E2f1 Mcm7 Cdkn1a Ccnh Creb3 Ccnb1 Tp53 Cdk6 Mcm5 Cdk7 Pcna Cdkn1b G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP520%RATTUS NORVEGICUS G13 signaling pathway Pik3r2 Pip4k2a Arhgef1 Pak3 Map3k4 Cdc42 Tnk2 Pik3cd Limk1 Rock1 Diaph1 Pkn1 Arhgdib Iqgap2 Ppp1cb Wasl Sh3rf1 Cit Cyfip1 Mybph Rps6kb1 Rac1 Rock2 Mapk10 Cfl2 PEPTIDE GPCRS%WIKIPATHWAYS_20260710%WP131%RATTUS NORVEGICUS Peptide GPCRs Npy2r Ghsr Npy1r Mc3r Cxcr1 Oprd1 Tacr1 Ednra Gnrhr Oprk1 Ntsr1 Cxcr4 Fshr Oprl1 Ccr5 Ccr2 Galr2 Cckbr Galr3 Galr1 Agtr1 Lhcgr Sstr5 Sstr2 Sstr4 Sstr3 Cxcr6 Sstr1 Tacr3 Avpr1b Tacr2 Mc5r Tshr Oprm1 Tac4 Fpr1 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Grpr Oxtr C3ar1 Cckar Ednrb Npy5r Ntsr2 Brs3 Mc2r Agtr2 Bdkrb2 Ccr7 Ccr6 Ccr3 Npy4r Mc4r OSTEOCLAST%WIKIPATHWAYS_20260710%WP489%RATTUS NORVEGICUS Osteoclast Ctsk Atp6v1e1 Itgb3 Ifnb1 Slc9a1 Tnfsf11 Ifnar1 Spp1 Trpv5 Zcchc2 SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260710%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Mtr Kmo Sod1 Ptgds Cat Tbxas1 Pnpo Xdh Mt-co2 Mthfr Selenok Gpx3 Selenop Fads1 Fads2 Ptgis Mt-co1 Gpx1 Gpx6 Alox5 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP654%RATTUS NORVEGICUS ATM signaling pathway E2f1 Ccne1 Chek2 Cdkn1a Casp9 Sfnl1 Cycs Pmaip1 Ccnb1 Gadd45a Rprm Ccnd1 Cdk6 Tp53 Bak1 Casp3 Rb1 Bax Cdk1 Necab3 Brca1}