S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Inpp5d Pi4kb Itpka Pi4ka Plch2 Inpp5a Plch1 Plcd1 Synj1 Inpp5b Plcd4 Itpkc Plcd3 Itpkb Itpk1 Ipmk Cdipt Pik3cg Pik3cb Ocrl Pik3cd Pip4p2 Pten Pip4p1 Inpp5k Pik3ca Pi4k2b Plcz1 Synj2 Inppl1 Pik3c2b Minpp1 Plce1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Cox6a1 Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adss1 Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Pdss1 Ubiad1 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Impdh1 Nme1 Guk1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Ggt5 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Ptgs2 Alox5 Lta4h PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Crym Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh2 Acat1 Bdh1 Hmgcs2 Hmgcl D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Elovl7 Fads1 Fads2 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt1 B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b1 Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Cbr1 Ptgs2 Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Ocrl Pip4p2 Pten Pip4p1 Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Mtmr14 Inpp4a Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ptgs2 Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Gstm4 Ephx3 Alox8 Alox12 Dpep2 Gpx4 Alox5 Cyp4f15 Dpep1 Cyp2j6 Alox15 Cyp4f3 Ltc4s Cyp2d22 Lta4h PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh2 Acat1 Bdh1 Oxct1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Maoa Cyp1b1 Cyp2c50 Cyp1a2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Dhtkd1 Aldh8a1 Acmsd GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx1 Gpx3 Gsr Gpx7 Gpx4 Gpx2 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Mboat1 Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Fbp2 Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl7 Tecr Elovl1 Hsd17b12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygl Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Metap2 Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1 Got1l1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Tk1 Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta5 Gsta3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp1 Xdh Rbp4 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1 Got1l1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Sult1a1 Aldh2 Aldh3a2 Maoa ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adss1 Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Plcb4 Pla2g2d Plcb3 Pla2g2f Pla2g4c Pla2g4e Pla2g4d Pld4 Plcb2 Pla2g4a Pld1 Plcb1 Plb1 Pld3 Pld2 Pla2g12a Pnpla8 Plcg1 Pla2g5 Plcg2 Pla2g3 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tyms Tk1 Nme3 Nme2 Nme5 Nme4 Cmpk2 Cda Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chka Cept1 Chkb Pcyt1b Pcyt1a Chpt1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Maoa Acmsd Ido1 Maob Dhtkd1 Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Gcdh Cyp1a2 Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acox2 Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Echs1 Acox1 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Aldh3a2 Akr1a1 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adss1 Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Ogdh Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp1 Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt1 B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Dpys Upp1 Dpyd Upp2 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt1 B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkm Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt1 B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rpe65 Rbp1 Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Impdh1 Guk1 Nme1 Nme7 Gmps Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp1 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ptgs2 Ephx3 Alox12 Gpx4 Alox5 Alox15 Cyp2d22 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cb Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Gnpda1 Pgm3 Hk2 Gck Gnpda2 Hk1 Gpi Hk3 Gale Hkdc1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl7 Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acsbg2 Acot4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Ptgr1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcb1 Plcz1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c21 Srd5a1 Akr1c6 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx1 Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Bbox1 Aldh9a1 Shmt1 Tmlhe 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Itpk1 Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Elovl7 Fads2 Elovl2 Elovl5 Hsd17b12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt1 B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Cyp2a5 Fmo4 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk2 Gck Hk1 Gpi Gfpt1 Hk3 Gfpt2 Hkdc1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Dhtkd1 Aadat Aldh7a1 Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sephs1 Sepsecs Sars2 Sars1 Pstk Sephs2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Gde1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acat2 Acsm1 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsl3 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Ptgs2 Alox5 Lta4h ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gpi Gmppb Mpi Pmm1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Otc Asl Cps1 Ass1 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Sqor Suox Tst HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Fech Hmbs Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Sds Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Cbs Dbt Cth Dld Bhmt Mcee Pcca Bhmt2 Mtr Pccb Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Gpat4 Plppr3 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Bcl2 Rac1 Fas Pkn2 Pkn1 Vim Dffa Mapk3 Cdk11b Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Ube4b Casp8 Lyn Casp7 Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Mapk1 Pdcd6 Bax ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Akt1 Ywhae Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Prkcd Pik3r3 Col17a1 Itga6 Trp73 Ntn1 Ephb2 Pak1 Shc1 Lamb2 Irs1 Lamb3 Pik3cg Sfn Irs2 Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Ar Lamc2 Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Sap18b Sufu Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Map2k1 Ikbkb Stat5b Pdia3 Csf2ra Slc2a1 Gab1 Prdx3 Stam2 Syk Rack1 Vav1 Sptan1 Crkl Rps6ka2 Ezr Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Hck Ptprc Sh2b2 Nfkbia Bcl3 Hnrnph1 Park7 Prkca Chuk Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Cd226 Foxo1 Itgb7 Ccl25 Gsk3b Itga4 Ccr9 Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Cdh1 Madcam1 Mapk1 Msn TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Map2k1 Stat5b Nos3 Tie1 Mapk3 Raf1 Dok2 Tek Nck1 Mapk14 Akt1 Stat5a Fes Bmx Map2k2 Ptk2 Pak1 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Akt1 Mapk14 Syk Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Rela Ccl11 Ccl7 Cd4 Ccl5 Ccl12 Ccl4 Pik3r1 Ccl2 Ccr5 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Prkcd Nfkbia Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Crk Stat5a Stat6 Stat1 Stat4 Erbb3 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL H2ax Ctnnb1 Dap3 Map3k7 Bex3 Chek2 Ikbkg Tnfrsf11b Mapk3 Prkaa1 Tradd Bak1 Bcl10 Xiap Akt1 Mcl1 Mapk14 Vdac1 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Bid Creb1 Src Casp8 Rela Casp7 Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Mapk1 Parp1 Ctsb Traf2 Bax NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Rbx1 Fhl1 Hivep3 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Gsk3b Psen1 Pofut1 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Rela Dll1 Dll3 Dll4 Itch Maml1 Smad1 Nfkb1 Ring1 Maml2 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Jak2 Lfng Tcf3 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Grap2 Stat3 Tfe3 Grb2 Gab3 Pstpip2 Dnm1 Stat5b Vim Csf1 Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Ptk2 Csf1r Myo18a Inppl1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Cdc25b Nono Trim68 Ncoa1 Bag1 Gtf2h1 Psmc3ip Rbak Cdk11b Ccnd3 Runx2 Nelfcd Kat2b Pelp1 Rb1 Cdk9 Xrcc6 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Brca1 Rac3 Rnf14 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Gsk3b Rnf4 Foxa1 Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Src Pnrc1 Pak6 Rela Stub1 Tgfb1i1 Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Hspb1 Brinp1 Nr2c2 Nr2c1 Nrip1 Ahr Hsp90aa1 Casp8 Uxt Casp7 Pias4 Kat5 Pik3r1 Ube2i Kat7 Gtf2f2 Gtf2f1 Casp3 Pias1 Sf1 Appl1 Ccnh Prdx1 Tle5 Casp1 Patz1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ep300 Ranbp9 Senp1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cbl Mapk3 Gab1 Cebpa Creb1 Akt1 Lyn Stat5a Flt3 Jun Cblb Gab2 Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Map2k1 Ikbkb Mapk3 Myc Mapk14 Syk Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id2 Id1 Elk1 Id4 Smad3 Id3 Myf5 Tcf7l2 Rbl2 Rb1 Rbl1 Cdk2 Elk4 Hes1 Tcf3 Myod1 Psmd4 Atf3 Pax5 Elk3 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Stat5b Il3ra Mapk3 Csf3r Pom121 Fth1 Pla2g1b Socs3 Akt1 Mapk14 Syk Syp Cdk2 Rel Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Stat5a Stat1 Gab2 Ptpn11 Jak1 Jak2 Tyk2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Akt1 Syk Vav1 Gsk3a Crkl H2bc7 Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Raf1 Mtor Braf Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Crk Stat5a Stat6 Stat1 Pla2g4a Jak1 Mapk8 Jak2 Prkcq Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Rb1 Cdk9 Ywhah Mapk14 Ywhae Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Stat1 Traf5 Relb Tnfrsf1b Tnfrsf1a Ptpn11 Nfkb2 Egfr Ikbkb Gab1 Syk Rel Rack1 Dok1 Nfkbia Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Stat5a Fbxw11 Txlna Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Mark2 Mapk8 Cdc34 Rasa3 Nfkbiz Papola Rps6ka5 Mapk1 Glg1 Bag4 Ywhab Sec16a Map3k7 Ripk3 Cradd G3bp2 Dcaf7 Ikbkg Cops3 Mapk3 Nfkbib Nfkbie Tradd Kpna6 Kpna3 Akt1 Ccnt1 Tab3 Tab2 Skp1 Traf7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Ube2d3 Copb2 Map2k5 Prkcd Smarcb1 Psmd13 Alpl Rasal2 Btrc Akap8 Hdac6 Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Jun Fancd2 Cops5 Psmd3 Psmd2 Traf3 Elp1 Psmd1 Cav1 Faf1 Ktn1 Spag9 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Crebbp Traf2 Rnf25 Traf1 Map3k11 Tnfaip3 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Hspb1 Brinp1 Cflar Nr2c2 Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Map2k1 Ret Th Raf1 Cdc25c Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Dok1 Nfkbia Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Nfkb1 Tnfrsf8 Relb Traf3 Nfkb2 Bcl3 Akt1 Rel Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Zap70 Creb1 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Map2k1 Ikbkb Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Crkl Rps6ka2 Cxcl12 Lck Gna13 Grk6 Fyb1 Plcg2 Ackr3 Cblb Esr2 Rhoa Vcam1 Limk1 Ptprc Usp14 Dok1 Nfkbia Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Pik3r1 Crk Sdc4 Ccr5 Pik3r2 Stat4 Cfl1 Map2k2 Mapk1 Stat2 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Src SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Plce1 Lgals1 Lgals3 Rasgrf1 Rasgrf2 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Aurkb Incenp IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Il10 Jak3 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Itgb3 Irf4 Lta Oprm1 Tff3 Inpp5d Akt1 Ptpn6 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Col1a2 Pigr Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Tert Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Shc1 Sgms1 Prkcz Rela Gab2 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Il2ra Nras Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Shc1 Gab2 Irs1 Lck Bdnf Afdn Ptpn11 Kdr Angpt1 Lmo4 Gab1 Ngf Frs2 Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Grb2 Ntf4 Sos1 Ntf3 Pdgfrb Ifngr1 Hras Vegfa Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Gata1 Ep300 Cdkn1b E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Crebbp Myb Tcf3 Ctbp1 Spen Hdac1 Neurog3 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Cd4 Maml2 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Jak2 Hes6 Tle1 Gaa Rbbp8 Kdm1a Rbpj Ncor1 Yy1 Notch1 Gata6 Rcan1 Myod1 Gata4 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgav Itgb6 Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Rock2 Ect2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ccne1 Cstf1 Bard1 Prkdc Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Stat5a Nras Pik3r1 Gab1 Ngf Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Akt1 Agap2 Sfn Egr1 Bad Foxo3 Ccnd1 Plcg1 Creb1 Gsk3b Prkcd Ywhaz Pik3ca Kras Shc1 Src IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Cd4 Mapk9 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Klhl9 Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Npm1 Cbx5 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Rhoa Klhl13 Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Rac1 Ntn1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca Src S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Map2k1 Mapk1 Pde3b Pik3cg Pik3r6 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Gata1 Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Col1a2 Map3k7 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Gata3 Ppid Atp2b1 Pax5 Zfpm1 Snd1 Ncor1 Maf Ptcra Kit Myod1 Smarca2 Mcm4 Ep300 Cd34 Bcl2 Lef1 Cebpb Mat2a Trim28 Cebpd Nlk Cebpa Sp1 Elane Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Hras Crebbp Ca1 Ski Zfhx3 Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Pxn Nras Pik3r1 Rras Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Src FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Ezr Mapk10 Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Pik3ca Casp8 Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Src Fadd PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Mapk8 Tradd Mapk1 Cradd Pdgfa Traf2 Mapk3 Ksr1 Prkra Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Syk Klk6 Yes1 Pld2 Ptk2b Grk5 Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd Src ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Pik3ca Btrc Syk Rela Src RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn2 Ezr Jun Pkn1 Cdkn1b Sh3gl2 Tln1 Pip5k1c Pip5k1b F2rl2 Fos Vcl Scai Mapk8 Rhoa Itgb1 Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Prkcz Limk2 Mrtfa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Src Irs1 Lck Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Dok1 Fcgr3 Csn2 Csf1 Insr Grb2 Trpv6 Txn Crk Ptpn1 Pdgfrb Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Ezr Prkaca Itga2 Mapk8 Mapk1 Sdc2 Csf2 Mapk3 Rhoa Itgb1 Hras Fgf15 Bax Cask Mmp2 Fn1 Kng2 Tnfrsf13b Sdcbp Ephb2 Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Nf1 Casp3 Src RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Map2k1 Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Mmp2 Arg1 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Esr1 Brca1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Il6 Ache Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Nos2 Dusp1 Nf1 Pdgfra Il23a Dusp10 Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna1 Efna2 Lck Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Src SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Gata1 Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Sin3a Fkbp3 Sin3b Pparg Chd3 Chd4 Sirt3 Sirt2 Hdac2 Sirt1 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Hdac1 Sirt5 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Sap30 Mxd1 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Vamp3 Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ep300 Cdkn1b Mapk10 Csnk1a1 Ran Csnk1g3 Fasl Kat2b Mapk8 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Crebbp Sod2 Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Cdk2 Csnk1e Ywhah Sirt1 Ywhag Ywhae Chuk Ywhab Akt1 Foxo4 Sfn Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Sgpl1 Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Chuk Ywhab Akt1 Foxo4 Sfn Rictor Bad Mtor Map3k5 Foxo3 Akt3 Foxo1 Akt2 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 Src E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Nme1 Pip5k1c Afdn Pik3r1 Rap1a Vav2 Ctnnd1 Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Src Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Stil Dhh Hhip Ihh Lrp2 Gli2 Hhat Pik3r1 Shh Akt1 Grk2 Lrpap1 Smo Arrb2 Ptch2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Bcar1 Noxa1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Map3k1 Arpc3 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Pip5k1a Arpc5 Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef6 Spata13 Fgd1 Nme1 Arhgef9 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Efna1 Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Crebbp Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Src Smarca2 Ep300 Pkn1 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Cav1 Srf Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncan Ptn Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Src Sdc3 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Esr1 Rps6ka4 Rps6ka5 Ptgs2 Hbp1 Atf2 Mknk1 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Pxn Tln1 Git1 Prkaca Itga4 Ptk2 Arf6 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Ptk2b Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Src Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Fzd8 Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Jun Cdkn1b Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Nfatc3 Ets1 Nfatc2 Atf2 Myb Il10 Mmp9 Th Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Col1a2 Ctnnb1 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Il5 Trip6 Sp1 Dmtf1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cbfb Cops5 Trp53 Fabp4 Timp1 Esr1 Agt Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Pik3ca Csf2rb2 Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Arhgef6 Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Akt1 Tacc3 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Creb1 Gsk3b Zyx Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Rhoa Ptpn1 Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Pik3ca Fgfr1 Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rarg Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ncoa1 Ppard Ppara Abca1 Nr4a1 Srebf1 Vdr Pparg Tgfb1 Ncor2 Rxrb Tnf Rxra Rxrg Fam120b Rara Rarb Med1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Chuk Myc Atp5pf Hdac1 C3 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Esr1 Brca1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Cdkn1a Tek Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Il2ra Nras Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Stat4 Ptpn7 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Pik3r1 Rras Mapk8 Mapk1 Itgav Rhoa Itgb1 Ets1 Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Src Rasa1 Pxn Tln1 Vcl Arhgef11 Nck1 Asap1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Ptk2 Capn2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb2 Lama2 Lamb3 Lama5 Lamb1 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Rfc4 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Fbxw11 Brca2 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Rrad Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Gsk3b Brca2 Yap1 Itga3 Hes1 Dlx5 Bdkrb2 Ppp2r5a Hells Cdkn2a Igfbp3 Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Notch1 Pou2f2 Ccnb2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Gsn Casp7 Krt18 Casp4 Satb1 Map3k1 Casp2 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Arhgef6 Spata13 Rasgrf1 Rasgrf2 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Vav3 Elmo1 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Mmp2 Jam2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Tnf Selp Rock1 Il6 Lrp1 Selplg Ccn2 Jam3 Plat Nfkb1 Ager Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Mapk3 Tiam1 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Fos Pla2g4a Mapk8 Mapk1 Mapk3 Nfatc2 Map2k4 Syk Fyn Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Shc1 Klrg1 Gab2 Hcls1 Rasa1 Cblb Wipf1 Pxn Fcer1g Lat2 Lcp2 Ptpn11 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Rhoa Pdgfrb Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 Akt1 S1pr3 Akt3 Jak2 Src A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Rasgrf1 Crkl Stat3 Nras Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Shc1 Mcf2l Gab2 Rasa1 Bdnf Ptpn11 Rap1a Gab1 Ngf Frs2 Frs3 Matk Sqstm1 Faim Prkci Maged1 Ngfr Grb2 Dnaja3 Ntf4 Sos1 Shc3 Ntf3 Crk Shc2 Gipc1 Hras Rgs19 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Kras Rapgef1 Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Syk Lat Yes1 Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Pik3ca Arf1 Pten Itk Hsp90aa1 Kras Btk Src ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Stat5a Wwp1 Nrg1 Pik3r1 Prl Mdm2 Prlr Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Ereg Hbegf Nrg2 Yap1 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Jak2 Dlg4 Pik3cb Grin2b Itch Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Stat3 Nras Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Vasp Efna1 Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Myo6 Epha2 Vcl Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkaca Prkcb Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Mapk1 Sh2d2a Hsp90ab1 Itgav Hgs Mapk3 Ptpn2 Rhoa Vtn Fyn Pak2 Ptk2b Itgb3 Akt1 Ptpn6 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Grb10 Dnm2 Ptpn11 Kdr Vcl Nck1 Gab1 Ptk2 Raf1 Grb2 Prkca Flt1 Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Mmp9 Hspd1 Prdx3 Supt3 Cad Nme2 Myc Taf4b Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Tk1 Tert Max Huwe1 Ep300 Nme1 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 Src SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Akt1 Ptpn6 Cbl Foxo3 Vav1 Pten Shc1 Kit Bcl2 Grb10 Ptpn11 Stap1 Ptpro Gab1 Spred1 Spred2 Matk Epor Dok1 Grap2 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Grb2 Map4k1 Sos1 Tec Epo Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Mapk9 Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Rac1 Tnc Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 Src DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Prkdc Pnkp Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Mapk3 Ptpn2 Rhoa Ets1 Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Shc1 Gab2 Src Sh3gl2 Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Crk Ptpn1 Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Hgf Egr1 Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Met Arhgef4 Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Tln1 Stat3 Pip5k1c Nras Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Ptk2 Egfr Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Sos1 Ptpn1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Src PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Vasp Grk3 Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Pik3r1 F2rl2 Gnb1 Gnai1 Gnai3 Prkca Rhoa Arhgdia Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Rhoa Itgb1 Gipc1 Rac1 Tnc Adam12 Ccl5 Mdk Fn1 Mmp9 Tnfrsf13b Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Mapk8 Kat8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Kat2b Csnk1g1 Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Jun Cblb E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Junb Ptpn1 Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Gata3 Itch Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Jun Gna15 Irs1 Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Mapk8 Gnai3 Mapk14 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Gng2 Ar Pik3r1 Fos Gnb1 Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 Src PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Plk3 Trp53 Chek2 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Sp1 Dmtf1 Nfatc1 Junb Nfatc3 Nfatc2 Itgb4 Fosl2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Il6 Usf2 Col1a2 Lif Ccl12 Dcn Thbd Mmp1a Mgp Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Cdc25a Dclre1c Rad17 Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Mapk8 Tradd Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Rela Fas Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Saa2 Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Bgn Hspd1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Rhoa Arhgdia Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Shc1 Irak1 Myd88 Traf6 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Mmp7 Ripk2 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Cav1 Gsk3b Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Mapk1 Sdc2 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Fgf23 Ncam1 Fgfr3 Fgfr4 Ssh1 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Pik3ca Fgfr1 Cttn Shc1 Src ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Fkbp1a Amhr2 Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Mak Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Ube2i Appl1 Hnrnpa1 Pias1 Ncoa6 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Vasp Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Src IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Stat1 Cebpd Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Junb Sos1 Hsp90b1 Lbp Mcl1 Map2k4 Rac1 Ptpre Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Foxo1 Vav1 Il6 Prkcd Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Mdm2 Rad51 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cdk2 Cep164 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Rfc4 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Cdc25a Ppp2ca Rad17 Plk1 Atrip Ccna2 Clspn Fbxw11 Brca2 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Grb10 Crkl Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Sos1 Ptpn1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Casp1 Map2k1 Pgr Vcam1 Il1b Nlrp1a Antxr2 Il18 Antxr1 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccne1 Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Cdc25b Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Arrb2 Dnm1 Pik3r6 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fgb Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Stat5a Mapk10 Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Mapk3 Ksr1 Ptpn2 Brk1 Rhoa Arhgdia Bcar1 Map2k4 Rac1 Baiap2 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Src Rasa1 Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Sla Arap1 Rab4a Usp6nl Grb2 Prkca Tagln Myocd Sos1 Dock4 Crk Ptpn1 Actn4 Csk Hras Nherf2 Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Fos Prkce Pla2g4a Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Jak2 Pik3cb Pik3ca Wasf2 Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Rap1a Vav2 Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 Src BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Akt1 Ptpn6 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Grb2 Map4k1 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Btk Pou2f2 Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Rhoa Arhgdia Vav3 Arhgap35 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Farp1 Arhgap6 Net1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Snap25 Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Il4 Dll3 Dll4 Mycbp Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Ctbp1 Cul1 Myc Skp1 Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Stat5a Lck Bcl2 Il2ra Ptpn11 Elf1 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Jun Mapk10 Stat3 Nrg1 Nras Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Jak2 Pik3cb Pik3ca Kras Shc1 Src Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Vasp Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Arrb2 Dnm1 Pik3r6 Ppp2r1a Plcb3 Rab11a Plcb1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fgb Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Spp1 Pdgfb Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Col4a3 Sphk1 L1cam Col4a4 Thbs1 Pecam1 Thy1 Cd47 Edil3 Col4a1 Ibsp Fbn1 Col4a5 Col4a6 Ccn1 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Stat3 Il2ra Nras Stat1 Prkcb Pik3r1 Fos Prkce Il2 Ifng Mapk8 Mapkapk2 Mapk1 Socs1 Mapk3 Rhoa Jak3 Jak1 Syk Fyn Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Shc1 Gab2 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc1 Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per2 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Atf2 Sphk2 Rab7 Mtor Mapk14 Il2rg Il2rb Nfkb2 Map2k3 Ccr5 Relb Gadd45g B2m Gzma Gadd45b Gzmb Lck Hlx Eomes Ccl4 Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Nfkb1 Cd247 Jak2 Cd3d Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Itgb5 Vtn Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Vtn Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Src Irs1 Pxn Tln1 Angptl3 F11r Mfge8 Adgra2 Ptpn11 Kdr Vcl Pi4kb Pi4ka Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Col5a2 Igf1r Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Rock1 Col6a3 Col4a6 Sdc1 Pik3ca Casp8 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Hdac4 Tuba1b Mef2d Acss1 Acss2 Hoxa10 Kat2b Tubb2a H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Myod1 Ppargc1a RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rarg Ep300 Ncoa2 Ncoa1 Prkaca Prkcg Nrip1 Kat2b Mapk8 Mapk1 Mnat1 Vdr Ccnh Prkca Mapk3 Hdac3 Cdk7 Rbp1 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Cdkn2a Hif1an Os9 Egln2 Naa10 Egln3 Cul2 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Ep300 Jun Cdkn1b Cebpb Ar Nkx3-1 Shh Fos Sp1 Ins2 Col18a1 Pou2f1 Nrip1 Vtn Esr1 Brca1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Dscam Nr2f2 Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Camk2a Setdb1 Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gng2 Mapk11 Nras Pik3r1 Gnb1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Mmp2 Igf1 Gnai2 Mmp9 Gna11 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Akt1 Strn Pelp1 Esr2 Hbegf Pik3ca Msn Plcb3 Kras Shc1 Plcb1 Src REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Cdx4 Jun Cdx1 Ctnnbip1 Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Ctbp1 Cul1 Myc Skp1 Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Sfn Cacna1g Myog Mdfic Dvl3 Ccnd1 Igf2bp1 Cby1 Fgf4 Zcchc12 Ywhaz Tbl1xr1 Kcnip4 Tnik Adcy7 Tle4 Ruvbl2 Med12 Tle2 Tle1 Krt1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Rap1a Vav2 Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Sos1 Epo Hras Bcl2l1 Lyn Socs3 Plcg2 Inpp5d Ptpn6 Cbl Plcg1 Mapk14 Nfkb1 Stat5b Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Gadd45b Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Rac1 Atm Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Zbtb17 Pin1 Ruvbl1 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Pdgfrb Ptgs2 Vegfa Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Lyn Lama1 Nrg1 Tgfb1 Tgfb3 Fgr Hck App Prnp Slit2 Gpc1 Serpinc1 Flt1 Fgf2 Vegfa Fgfr1 Smad2 Tgfbr1 Blk Tgfbr2 Fyn Yes1 Src ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Fos Pla2g4a Prkce Mapk8 Mapk1 Ednrb Ednra Mapk3 Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Plcb2 Edn2 Edn3 Prkch Ptk2b Cysltr2 Cysltr1 Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Col3a1 Map2k1 Gna15 Gna14 Gnaq Prkcd Mmp1a Adcy7 Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Flt1 Pgf Vegfb Vegfa Kdr Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Jun Mapk10 Pik3r1 F2rl2 Nck1 Mapk8 Prkci Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Akt1 Cd2ap Kirrel1 Arrb2 Bad Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Prkcz Trpc6 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Jun Gng2 Pik3r1 Fos Gnb1 Prkce Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Ptk2 Gnai1 Gnai3 Crk Hras Nherf2 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Col1a2 Nid1 Cspg4 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lama2 Lamb3 Lamb1 Lamc2 Vegfa Col11a1 Tnc Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Col6a1 Col5a2 Lama1 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fgb Fga Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Rac1 Itgb2 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Itga3 Fpr1 Itgb5 Klk4 Fpr2 Gpld1 Plaur Fpr-s1 Mmp12 Serpine1 Plg Ctrc Mmp13 Vldlr Src VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Lgals1 Cdkn1b Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Foxo3 Wnt5a Creb1 Col1a2 Id2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Max Tmem126a Dkk1 Ep300 Sfrp1 Bcl2 Tbp Csde1 Tsc2 Hmgcs2 Cebpd Nfyb Nfya Cebpa Sp1 Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Ereg Hbegf Nrg2 Btc Areg Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gata1 Gng2 Gnb1 Grk2 Ranbp2 Hdac4 Tuba1b Ube2i Ran Tubb2a Hdac3 Ankra2 Hdac5 Esr1 Bcor Hdac7 Hdac6 Rfxank Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Nedd4l Tgfbrap1 Smad2 Zfyve16 Smad3 Ppp2cb Smurf2 Smad4 Tab2 Strap Tab1 Dab2 Dact2 Tgfbr3 Sptbn1 Ywhae Ppp2r2a Pdpk1 Rnf111 Camk2a Ppp1r15a Zfyve9 Smad7 Bambi Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Lcp2 Prkcb Dbnl Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Chp1 Bcl2 Rcan2 Fkbp1a Prkaca Prkcg Prkcb Prkce Nr4a1 Mef2d Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Map3k1 Ywhag Ywhae Ywhab Fkbp8 Map3k8 Sfn Nup214 Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Inpp5d Akt1 Ptpn6 Cbl Vav1 Pten Itk Prkcq Shc1 Gab2 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Grb2 Prkca Trpv6 Map4k1 Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Flna Dbnl Map3k8 Sla2 Orai1 Stim1 Cd3e Plcg1 Stk39 Rassf5 Was Ikbkb Cd4 Fyb1 Sh3bp2 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Prkaca Prkcb Pik3r1 Nck1 Mapk1 Prkca Flt1 Mapk3 Shc2 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Akt1 Cd2ap Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Grb2 Ednra Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Prkaca Shh Gnb1 Smo Ptch1 Pias1 Csnk1a1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Sin3b Gnaz Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Sap30 Prkcd Rab23 Gli1 Gli3 Mtss1 Sap18b Ift88 Kif3a Stk36 Ift172 Btrc Sufu Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Exoc1 Exoc2 Grb10 Ptpn11 Pik3r1 F2rl2 Eif4ebp1 Exoc7 Nck1 Ins2 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Sos1 Ptpn1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Exoc3 Sorbs1 Exoc4 Rapgef1 Shc1 Prkcz Exoc5 Exoc6 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfd Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Efna1 Pak1 Inppl1 Pik3r1 Epha2 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Pik3ca Vav3 Arhgap35 Acp1 Shc1 Src ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Mapk1 Sh2d2a Mapk3 Ksr1 Brk1 Map2k4 Rac1 Baiap2 Arpc1b Actr2 Pld1 Actr3 Pld2 Map3k1 Arpc3 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ywhag Ppp2r2a Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Kras Mapk7 Prkcz Zfp36 Map3k2 Jun Mylpf Ralgds Arf4 Ppp5c Nras Diaph3 Map2k5 Fos Dusp6 Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Akt1 Eps8 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Mef2c Egf Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Pik3ca Wasf2 Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Lrpap1 Pafah1b3 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Cdk5 Dync1h1 Cdk5r1 Ndel1 Reln Dcx Rhoa Pla2g7 Iqgap1 Rac1 Abl1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Ccne1 Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Mapk3 Rhoa Agt Itgb1 Ptp4a3 Rhoc Bcar1 Ptp4a2 Rabggta Rac1 Rabggtb Atf5 Cdk2 Src EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca Src VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Sos1 Itgb1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Efna1 Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Egf Fbxo8 Cyth2 Ipcef1 Acap2 Gna11 Cyth3 Kif13b Lhcgr Gna15 Itgb3 Iqsec1 Gna14 Arap2 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Src P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Gata1 Mapk11 Trp63 Mdm2 Pml Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Myc Tuba1a Bub1 Ccne2 Pea15 Il1rap Clca2 Ndufs2 Plk1 Hagh Foxo3 Gramd4 Aen Dcp1b Trp73 Rnf43 Mapk14 Dedd Flot2 Afp Hsf1 Wt1 Bak1 Cdk1 Bub3 Il4ra Serpine1 Ube4b Nsg1 Gdf15 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Cdk2 Ada Serpina1d Ntrk1 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Rela Fas CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Gng2 Mapk11 Arrb1 Nras Pik3r1 Gnb1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Cxcl9 Mapkap1 Map2k6 Mlst8 Pik3cb Pik3ca Cxcl11 Map2k3 Cxcl10 Cxcr3 Kras Pf4 Src Cxcl13 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Il3ra Cnksr1 Stat5a Srp9 Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Hdac1 Inpp5d Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Shc1 Gab2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Grk3 Gng2 Mapk11 Prkaca Prkcg Prkcb Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Syk Fyn Yes1 Prkch Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Src Lck Ptgdr Ptgir Prkg1 Tbxa2r Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Itga6 Pik3r1 Cd9 Il1a Pmp22 Egfr Lamb2 Lama2 Grb2 Lamb3 Prkca Lamb1 Itgb1 Lamc2 Hras Mst1 Itgb4 Rac1 Erbb3 Casp7 Egf Ywhah Lamc1 Ywhag Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Eif4ebp1 Clip1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Raf1 Tsc1 Eif4b Ulk1 Ulk2 Prkca Rb1cc1 Poldip3 Pdcd4 Hras Atg13 Eef2 Sgk1 Map2k2 Cdk2 Ywhah Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Tigar Cebpz Nlrc4 E2f2 Prdm1 Prkab1 Ctsd Ppm1j Trp63 Mdm2 Col18a1 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Trrap Edn2 Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Snai2 Ndrg1 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Gadd45a Igfbp3 Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Serpine1 Gdf15 Atf3 Dkk1 Ep300 Bcl2 E2f1 Vcan Sp1 Ddit4 Egfr Kat2a Vdr Casp6 Crebbp Drosha Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Cdkn1a Rgcc Steap3 Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Rb1 Aifm2 Dgcr8 Htt Bid Scn3b Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Fas Mlh1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Rps6ka5 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Nme1 Snx1 Adam10 Dnm2 Bdnf Gdnf Slit1 Gfra1 Cbll1 Dsp Ctnnd1 Rab5a Cables1 Mep1b Igf2 Egfr Arf6 Cdh2 Robo1 Zbtb33 Hgs Ptpn1 Hras Crebbp Rac1 Abl1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Ret Casp3 Ctnna1 Src AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Ran Aurkaip1 Tacc1 Oaz1 Aurkb Cpeb1 Trp53 Ndel1 Ajuba Dlgap5 Tdrd7 Brca1 Fzr1 Pak1 Akt1 Tacc3 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Jun Cblb Stat5a Mapk10 Traf6 Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Jak3 Tnfaip3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Ddx54 Zfp709 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Ezr Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Smad4 Stk26 Mark4 Crtc2 Ywhah Stradb Ywhag Smarcd3 Ywhae Strada Cab39 Etv4 Myc Ywhab Stk11 Sik3 Sik2 Sik1 Sfn Psen2 Brsk2 Brsk1 Mtor Creb1 Gsk3b Rptor Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map3k2 Nras Map2k5 Fos Rap1a Cdk5 Raf1 Mapkapk2 Mapk1 Cdk5r1 Mapk3 Ntf3 Rps6ka5 Hras Rit1 Mef2c Rit2 Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Creb1 Srf Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Kras Mapk7 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map3k5 Map4k5 Tnf Map4k3 Cav1 Birc3 Adam17 Tnfrsf1b Ikbkb Cyld Birc2 Map3k7 Map4k2 Ikbkg Rffl Map2k7 Tnik Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Cpt1a Bdh1 Foxf1 Cebpb Abcc8 Kcnj11 Alb Cebpd Apoa1 Hnf1a Cebpa Sp1 Cpt1b Ins2 Cpt1c Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl F2 Alas1 Tfrc Ttr Igfbp1 Ucp2 Slc2a2 Nf1 Pck1 Pdx1 Nr3c1 Acadm Gck CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Rasgrf1 Diaph3 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Map3k1 Arpc3 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Src Arhgef6 F2rl2 Exoc7 Cdc42bpa Septin2 Pax6 Raf1 Hes5 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Stat5a Gng2 Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Akt1 Ptpn6 Fgr Hck Pik3cg Pik3r6 Arrb2 Mtor Foxo1 Vav1 Arr3 Stat5b Cfl1 Limk1 Src Lck Pxn Ptpn11 Cxcr4 Ptk2 Gnai1 Gnai3 Rgs1 Ubqln1 Vps4a Vps4b Crk Grk6 Stat2 Rhoc Ralb Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Jak2 Cd3d Pik3cb Itch Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhag Ywhae Tcf3 Mapk11 Ywhab Tsc2 Sfn Hspb1 Creb1 Mapkapk3 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Jun Dkk1 Ppp2r5d Adam10 Psen1 Ppard Nlk Fos Hnf1a Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Crebbp Nkd1 Dkk2 Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Mdm2 Pml Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Ada Nqo1 Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Serpinb5 Aen Prkcd Ikbkb Egr2 Flot2 Itga3 Cdkn2a Gadd45a Igfbp3 Itch Btrc Gdf15 Fas IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Il1b Crkl Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Mapk1 Socs1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Map3k1 Pias4 Casp1 Map2k1 Dapk1 Camk2a Ptges2 Irf9 Smad7 Akt1 Map3k11 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Pip5k1a Ap2m1 Gbf1 Uso1 Gga3 Kdelr1 Asap1 Ap2a1 Arfip2 Gosr2 Cltb Copa Arfgap1 Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Jun Myd88 Traf6 Il1b Il1r1 Map3k3 Irak4 Pik3r1 Il1a Sqstm1 Mapk8 Prkci Tab2 Tab1 Casp1 Chuk Il1rap Ikbkb Ube2v1 Map3k7 Ticam2 Ikbkg Irak3 Erc1 Map2k6 Tollip Nfkb1 Il1r2 Il1rn Ube2n Pik3ca Prkcz Irak1 Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Pbx1 Jun Krt14 Stat5a Smarcc2 Mapk10 Mapk11 Pomc Ppp5c Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Mapk8 Mapk1 Cdk5r1 Nfatc1 Spi1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Ep300 Tbp Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nfkb1 Nr1i3 Tsg101 Smarcc1 Kmt5b Sele Fkbp5 Tbx21 Vipr1 Pou1f1 Irf1 Smarca4 Smarcd1 Fkbp4 Cga Rela Pck2 Krt17 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Cblb Stambp Sh3gl2 Amph Chmp3 Epn1 Nras Pik3r1 Zfyve28 Rab5a Ptk2 Egfr Raf1 Grb2 Hgs Sos1 Ube2d3 Hras Ube2d1 Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Kras Arhgef7 Shc1 Src E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ccnd3 Ranbp1 Mcm3 Ces2h Ces4a Prmt5 Pola1 Apaf1 Dhfr Rybp Orc1 Mcl1 Ces3b Hbp1 Rrm1 Ces5a Rrm2 E2f6 Trrap Casp7 E2f7 Wasf1 Sirt1 Cdc6 Plau Myc Hdac1 Ccne2 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Tk1 Ccne1 Smarca2 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Rbbp4 Topbp1 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Chuk Bcl10 Tnf Tnfrsf1a Ran Ikbkb Cyld Birc2 Ikbkg Erc1 Prkca Nfkb1 Ube2d3 Atm Btrc Tnfaip3 Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Akt1 Ptpn6 Cbl Vav1 Prkcq Shc1 B2m Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Grb2 Prkca Trpv6 Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Cd3e Plcg1 Rassf5 Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Jun Cdkn1b Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Hdac2 Tinf2 Parp2 Tnks Dkc1 Pot1 Myc Pif1 Hdac1 Wrn Tgfb1 Acd Akt1 Znfx1 Terf2ip Hnrnpc Pinx1 Mtor Sap30 Mxd1 Sap18b Terf2 Wt1 Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Sp3 Egfr Rad50 Rbbp4 Rbbp7 Xrcc6 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Ywhae Nr2f2 Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Jun Cdkn1b Mapk11 E2f2 Mitf Mdm2 Ccnd3 Spi1 Csf2 Hdac3 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Tfdp1 Suv39h1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Myod1 Ccne1 Ep300 Tbp Cebpb E2f1 Elf1 Cebpd Cebpa Gsc Runx2 Raf1 Cbx4 Rbbp4 Skp2 Crebbp Abl1 Cdk6 Mef2c Sftpd Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Met Rb1 Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Mapk3 Ppm1a Nup153 Ctdspl Smad2 Tgfbrap1 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Akt1 Ldha Hmox1 Creb1 Id2 EG433182 Plin2 Tfrc Adm Serpine1 Cp Igfbp1 Pfkfb3 Eng Nt5e Car9 Pgm1 Fech Pkm Gck Tert Aldoa Ep300 Abcb1a Pfkl Rora Hk2 Edn1 Ncoa2 Hk1 Ncoa1 Bhlhe41 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Crebbp Furin Egln3 Smad3 Lep Cited2 Smad4 Pgk1 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Pik3r1 Grin2a Mapk8ip1 Rap1a Lrpap1 Pafah1b1 Dab1 Cdk5 Mapk8 Cdk5r1 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Akt1 Map3k11 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Mapk8 Tradd Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Pik3ca Casp8 Smpd1 Ripk1 Map3k1 Fadd RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk14 Gng2 Mapk11 Gnb1 Crh Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Stat5a Stat3 Stat1 Pik3r1 Kdr Eif2ak2 Ins2 Csf1r Itga1 Gab1 Lman1 Pias1 Egfr Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Sos1 Ptpn1 Pdgfrb Itgb1 Eif2a Vegfa Crebbp Pdgfb Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 Src BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Mapk1 Rgmb Xiap Rgma Hjv Chrd Cer1 Bmp4 Fst Nog Bmpr1a Ski Bmp6 Zfyve16 Bmp2 Smad6 Smad4 Smurf2 Tab2 Tab1 Smurf1 Ppp1r15a Smad7 Bambi Nup214 Ppp1ca Gsk3b Bmpr2 Map3k7 Smad1 Smad9 Ppm1a Bmp7 Ctdspl Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 F2rl2 Gnb1 Rock1 Rhoa F2 Plcb2 F2rl3 Myl2 Gna11 FSH%NETPATH%FSH FSH HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor TCR%NETPATH%TCR TCR LEPTIN%NETPATH%LEPTIN Leptin KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor BCR%NETPATH%BCR BCR TNFALPHA%NETPATH%TNFALPHA TNFalpha ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin WNT%NETPATH%WNT Wnt IL6%NETPATH%IL6 IL6 TSH%NETPATH%TSH TSH EGFR1%NETPATH%EGFR1 EGFR1 ID%NETPATH%ID ID IL9%NETPATH%IL9 IL9 IL3%NETPATH%IL3 IL3 IL5%NETPATH%IL5 IL5 IL4%NETPATH%IL4 IL4 IL-7%NETPATH%IL-7 IL-7 NOTCH%NETPATH%NOTCH Notch IL2%NETPATH%IL2 IL2 TSLP%NETPATH%TSLP TSLP RANKL%NETPATH%RANKL RANKL IL1%NETPATH%IL1 IL1 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Tkt Hk2 Hk1 Rpia Gpi Taldo1 Hkdc1 Pgd ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Hk2 Hk1 Gale Galt Aldob Aldoc Aldoa Hkdc1 Khk P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Srf Traf6 Map3k7 Elk1 Mef2d Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Cryab Mapk3 Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Prkce Sphk1 Prkca Pik3r1 Raf1 Pik3r2 Lpxn Arhgap8 Pik3r3 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Map2k1 Tgfb1i1 Hras INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Il23a Il20ra Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Srf Mtor Il2 Il4 Elk1 Il6 Il5 Il7 Il9 Il12rb1 Il21 Il12rb2 Mapk15 Spic Mapkapk2 Il1a Stat5a Stat5b Il6ra Il4ra Stat3 Stat2 Mknk2 Stat1 Mknk1 Chuk Cdkn1a Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 Pik3cb Pik3ca Nos3 Il10 Il11 Ikbkb Spi1 Mapk7 Stat6 Il15 Irs1 Cxcr1 Cxcr2 Il13 Stat4 Il2ra Il18 Il2rb Irs2 Il15ra Sla2 Mapk6 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Flad1 Rfk HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Ears2 Cox10 Ppox Alad Qars1 Hmbs Rsad1 Fech Eprs1 Cpox Urod NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 Cacna1g Cacna1c Chrnb4 Epb41l2 Chrnb3 Kcnk3 Clic6 Ppp1r1b Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Cry2 Csnk1d Csnk1e Bmal1 Per2 Per1 Per3 Cry1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Sqle Fdps Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Nras Pik3r1 Pik3r2 Pik3r3 Pik3cg Pik3cb Pik3cd Mapk12 Pik3ca Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Ccne1 Cdkn1a Ccng1 Ctnnb1 Kras Trp63 Mapk11 Ppp2cb Rb1 Ppp2ca Trp53 Tpte Pten Pik3c2g Rbl1 Pik3c3 Cdk2 Pik3r5 Siah1a Atm Trp73 Pdpk1 Akt1 Akt3 Akt2 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb1 Prkch Hrh1 Prkci Gng3 Gng4 Prkcb Gng7 Gnaq Gng8 Prkcd Gngt2 Prkce Plcz1 Plce1 Gnb1 Prkca Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Prkcz Plcb4 Plcb3 Gna11 Gng10 Plcg1 Gna14 Gng2 Plcd1 Prkcq Plcb2 Plcg2 Plcd4 Prkcg METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin2b Prkaca Prkcb Gnaq Itpr1 Grin2a Prkar1a Prkar1b Prkx Prkacb Grina Plcb4 Grm1 Grm5 Gna11 Homer1 Grik5 Grik1 Grin1 Grin2d Grin2c OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng3 Prkaca Gng4 Kcnk9 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnai1 Gnb3 Gnb5 Gng12 Prkx Prkacb Gnao1 Adcy7 Prkar2a Prkar2b Htr1d Htr1f Gnai2 Htr1b Htr1a Gng11 Gnai3 Kcnk3 Gng10 Gng2 Adcy2 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb1 Prkch Prkci Gng3 Gng4 Prkcb Gng7 Gnaq Gng8 Prkcd Gngt2 Prkce Plcz1 Plce1 Gnb1 Prkca Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkcz Oxtr Plcb4 Plcb3 Gna11 Gng10 Plcg1 Gna14 Gng2 Plcd1 Prkcq Plcb2 Plcg2 Plcd4 Prkcg 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng3 Adcy7 Gng4 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Htr4 Gnb5 Gnal Gng12 Gng10 Gng2 Adcy2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Prkaca Gng4 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnai1 Gnb3 Prkar1a Prkar1b Prkacb Gnao1 Adcy7 Prkar2a Prkar2b Gng11 Gnai3 Cacna1a Cacna1b Gabbr1 Gabbr2 Cacna1g Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Adcy9 Kcnj3 Adcy2 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2g1 Ube2l6 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Uba6 Ube2k Uba7 Ube2n ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway Lrp4 Lrp5 Wnt6 Gsk3b Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Cd44 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Trim3 Jup Fzd5 Trim2 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Kat5 Wnt5a Cdh1 Trpc1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Wnt10a Ctnnb1 Bace2 Wnt10b Bace1 Acta1 Acta2 Actb Actr2 Notch4 Ern1 Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Lrp1b Wnt16 Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh1a3 Aldh2 Aldh3a1 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Trp73 Cop1 Trp63 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank2 Pank4 Ppcs Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Sos2 Sos1 Itpr3 Itpr2 Itpr1 Mapk12 Mapk13 Mapk14 Chuk Mapk11 Mapk1 Mapk3 Rac2 Rac1 Araf Plcg2 Mapk9 Mapk8 Nfkbil1 Nras Cd22 Prkcb Vav3 Syk Vav1 Prkcd Vav2 Map3k3 Map3k2 Blnk Btk Raf1 Cd79a Cd79b Ptpn6 Lyn Ptprc Ppp3ca Jun Ppp3cb Pik3cg Nfkbia Cd19 Pik3cb Grb2 Pik3cd Mapk10 Pik3ca Map2k2 Map2k1 Hras Ikbkb Fos P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Prkab1 Prkag1 Trp63 Ppp2cb Ppp2ca Trp53 Trp73 Akt1 Eif4ebp1 Akt3 Tsc2 Tsc1 Akt2 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb1 Liph Dagla Lpl Pla1a Plcb3 Plcb2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Gmppb Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrpa Snrnp40 Zrsr2 Prpf3 Snrpb2 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Mtor Rorc Arnt Hif1a Txn Txn2 Crebbp Egln2 Egln3 Akt1 Akt3 Vhl Akt2 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Ep300 Creb3l4 Polr2h Creb3l1 Polr2e Creb3l2 Ttf2 Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Tbp Prkar1a Brf2 Prkar1b Brf1 Tbpl2 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 Prkar2a Prkar2b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnao1 Gng3 Adcy7 Pomc Gng4 Oprd1 Gng7 Gng8 Gngt2 Gnai2 Gnb1 Gnb2 Gnb4 Gnai1 Gnai3 Gnb3 Gnb5 Gng12 Gng10 Gng2 Adcy2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Oxt Avp GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1a Prkar1b Prkacb Adcy7 Prkar2a Prkar2b Mapk1 Pla2g4a Ednrb Gnal Ednra Adcy3 Edn1 Edn2 Mapk3 Adcy4 Edn3 Adcy1 Adcy10 Adcy8 Gucy1b1 Adcy5 Prkg2 Akt1 Adcy6 Prkg1 Adcy9 Gucy1a1 Gucy1a2 Araf Prkcq Adcy2 Prkcg Prkch Prkci Prkaca Prkcb Prkcd Prkce Prkca Raf1 Prkcz Nos3 Map2k2 Map2k1 Plcb4 Akt3 Plcb3 Akt2 Gna11 Gna14 Plcb2 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Tyms Gch1 Fpgs 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcb1 Prkch Prkci Gng3 Gng4 Prkcb Gng7 Gnaq Gng8 Prkcd Gngt2 Prkce Plcz1 Plce1 Gnb1 Prkca Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkcz Gng11 Plcb4 Plcb3 Gna11 Gng10 Plcg1 Gna14 Gng2 Plcd1 Htr2a Prkcq Plcb2 Htr2c Plcg2 Plcd4 Htr2b Prkcg INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk3 Rac2 Rac1 Araf Col14a1 Map3k5 Itgbl1 Nras Crkl Arfgap1 Col10a1 Col1a2 Col5a2 Col5a3 Col5a1 Dmbt1 Pik3r1 Col9a2 Raf1 Col9a3 Pik3r2 Col9a1 Lama5 Arpc1b Pik3r3 Arpc1a Lama1 Pxn Lama2 Lama3 Lama4 Pik3cg Flnb Tln1 Pik3cb Vcl Pik3cd Vasp Pik3ca Col17a1 Col13a1 Fn1 Pik3c2b Itga7 Pik3c2a Itga8 Ptk2 Arl1 Map2k2 Itga5 Map2k1 Itga6 Itga9 Hras Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Itga11 Col4a3 Actb Col4a4 Cav1 Arpc3 Col4a1 Arpc2 Col4a2 Col8a1 Col4a5 Col8a2 Mapk6 Col4a6 Parvb Arpc5 Parva Rap2b Rap2a Col16a1 Arf1 Rap2c Col12a1 Ilk Itgax Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Sos2 Itgae Sos1 Arhgap10 Shc1 Itgal Rap1a Col3a1 Rap1b Actg1 Itgad Itgb8 Itgb6 Itgb7 Itgb1 Actbl2 Itga2b Actn2 Itgb4 Rras Itgb5 Itgb2 Actn1 Actn4 Col20a1 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Src Col11a2 Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a1 Col6a2 Ptk2b Col6a3 Lims2 Map2k3 Lamc3 Rapgef1 Lamc1 Lamc2 Mapk9 Mapk8 Map3k3 Map3k2 Flna Mapk10 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Itpr3 Srf Itpr2 Itpr1 Elk1 Map3k4 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Pik3r1 Raf1 Pik3r2 Arhgap8 Pik3r3 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Arhgap10 Shc1 Mapk15 Stat5a Stat5b Arhgap26 Stat3 Stat2 Stat1 Chuk Srgap1 Ehf Srgap3 Rab11b Arhgap6 Arhgap5 Mapk8 Arhgap4 Erf Erg Arhgap9 Vav3 Shc3 Rasa2 Vav1 Rasa1 Vav2 Rasa4 Map3k2 Pdgfrb Pdgfra Pdgfrl Pdgfa Pdgfb Grap Fli1 Rps6kc1 Fev Jun Gabpa Nck2 Jak2 Jak1 Grb2 Nck1 Arhgap15 Mapk10 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Rps6kb2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Pik3r5 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Actg1 Myo6 Myo18b Myo5a Myo9a Actbl2 Slc5a7 Chrnd Actc1 Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Myo15a Myo16 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 Acta1 Acta2 Actb Slc44a3 Actr1a Myo3a Actr1b Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat3 Stat1 Jak2 Jak1 Stat6 Jak3 Stat5a Stat5b Stat4 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psph Psat1 Phgdh AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3r1 Pik3r2 Pik3r3 Pik3cg Pik3cb Pik3cd Vasp Pik3ca Pik3c2b Pik3c2a Ntn1 Ntn3 Nfatc4 Rhou Ntn4 Nfatc3 Nfatc2 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Pik3r5 Rac2 Rac1 Plcg1 Plcg2 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a17 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc6a3 Slc6a19 Slc18a2 Slc6a18 Slc6a15 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Actbl2 Actc1 Rhou Rac2 Rac1 Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Arpc1b Pak4 Arpc1a Tubb5 Tubb6 Tubb3 Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Tubb4a Rock1 Acta1 Acta2 Actb Arpc3 Myo3a Arpc2 Myo3b Arpc5 Myh1 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Rasa1 Sos2 Sos1 Raf1 Elk1 Ins2 Insr Irs4 Map2k2 Rps6kb2 Igf2r Rps6ka4 Map2k1 Igf2 Rps6ka5 Igf1 Insrr Igf1r Irs1 Mapk1 Irs2 Mapk3 Map2k3 Fos INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Stat1 Ifng Jak2 Ifngr2 Jak1 Ifngr1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Uck1 Uck2 Uckl1 Adat2 Upp1 Uprt Upp2 Nme3 Nme2 Nme4 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Gria1 Slc1a1 Gng3 Slc1a3 Gng4 Slc1a2 Gng7 Slc1a7 Slc1a6 Gng8 Stx1b Gngt2 Cacnb1 Snap29 Stx1a Snap25 Gnb2 Snap23 Gnb4 Grik2 Gnb3 Grik4 Gnb5 Grik3 Grin2a Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Grik5 Grik1 Grin1 Grin2d Grin2c Grin2b Prkar2a Prkar2b Gnai2 Gnai3 Cacna1a Cacna1b Adcy10 Prkaca Gnb1 Gnai1 Cacna1e Grm4 Grm7 Grm8 Vamp8 Vti1a Vamp1 Vamp3 Gng10 Gria4 Vamp2 Gria3 Gria2 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Atf2 Eif2ak2 Birc3 Birc2 Tnf Tnfrsf1b Madd Bcl2l11 Tnfrsf1a Tradd Nfkb2 Nfkb1 Traf2 Bcl2l1 Xiap Endog Map2k4 Tnfsf10 Rela Relb Map3k1 Apaf1 Chuk Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Atf4 Mapk1 Jdp2 Atf3 Aifm1 Gzmb Map2k7 Gzmf Map4k4 Map4k3 Mapk3 Atf6b Fasl Cradd Bak1 Map2k3 Akt1 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Prkcq Ripk1 Map4k2 Prkcg Diablo Mapk9 Prkch Bax Mapk8 Map3k5 Rel Bcl2 Prkcb Fas Daxx Map3k14 Prkcd Prkce Prkca Jun Pik3cg Nfkbia Pik3cb Pik3cd Mapk10 Pik3ca Casp9 Igf2r Ikbkb Trp53 Akt3 Akt2 Fos LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Rhoc Rps6ka3 Gsk3b Rhoa Rps6ka6 Rps6ka1 Rhob Rps6ka2 Sos2 Sos1 Shc1 Atf2 Srf Elk1 Map2k6 Map3k4 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Map2k4 Stat3 Map3k1 Stat1 Mapk11 Mapk1 Braf Map2k7 Ets1 Pik3c3 Mapk3 Rac2 Map2k3 Akt1 Rac3 Rac1 Araf Mapk9 Mapk8 Nras Tiam1 Rala Ralb Exoc2 Pak1 Pld1 Raf1 Pld2 Pak3 Ralgds Pak2 Rgl1 Jun Pik3cg Pik3cb Grb2 Pik3cd Mapk10 Pik3ca Map2k2 Gsk3a Map2k1 Hras Kras Pdpk1 Akt3 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Gnb1 Prkca Gnb2 Gnb4 Raf1 Gnb3 Gnb5 Grk3 Itpr3 Grk2 Agtr1a Itpr2 Arrb2 Itpr1 Elk1 Arrb1 Egr1 Agt Map2k2 Map2k1 Gng11 Mapk1 Mapk3 Plcb3 Gng10 Plcb2 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Polr2h Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 Gtf2a1l Polr2c Taf1c Taf9 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Ep300 Gadd45g Sin3a Sumo3 Chek2 Pik3ca Gadd45b Gadd45a Wrn Traf2 Hdac1 Sfn Cdkn2a Mta2 Kat2b Gtse1 Ccne1 Pml Cdk1 Sirt1 Cdkn1a Cdc25c Trp63 Trp53 Tpte Pten Cdk2 Mdm2 Mdm4 Atm Crebbp Trp73 Pdpk1 Akt1 Akt3 Akt2 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Cacnb1 Plcz1 Snap29 Plce1 Snap25 Gnb2 Snap23 Gnb4 Gnb3 Gnb5 Gng12 Cacna1a Cacna1b Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Gnb1 Prkcz Trh Trhr Stx3 Cga Cacnb3 Cacnb4 Cacnb2 Tshb Cacna1e Plcb4 Vamp8 Plcb3 Vamp1 Gna11 Vamp3 Gng10 Gna14 Vamp2 Plcd1 Plcb2 Plcd4 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Soat2 Hsd17b3 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 Hsd17b7 Hsd17b6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Ctnnb1 Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Rela Skil PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Nt5e Aldh6a1 Dpys Dpyd Abat Dpysl2 Dpysl3 Cda Upb1 Dpysl5 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Prkaca Gng3 Adcy7 Prkar2a Gng4 Prkar2b Gng7 Adrb1 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 Prkx Prkacb Gng10 Gng2 Adcy2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Igf2 Igf1 Insrr Gsk3b Igf1r Foxo1 Irs1 Tpte Pten Irs2 Mdm2 Mdm4 Pdpk1 Pik3ca Tsc2 Tsc1 Ins2 Foxo3 Insr Irs4 Gsk3a Igf2r HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Prkaca Gng3 Adcy7 Prkar2a Gng4 Prkar2b Gng7 Gng8 Gngt2 Hrh2 Gnb1 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 Prkx Prkacb Gng10 Gng2 Adcy2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng3 Adcy7 Gng4 Gng7 Gng8 Gngt2 Adrb3 Gnb1 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 Gng10 Gng2 Adcy2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Nt5e Ampd3 Gda Xdh METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gng3 Pomc Gng4 Gng7 Gnaq Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Crh Gnb3 Gnb5 Crhr2 Gnal Crhr1 Gng12 Gna11 Gng10 Gna14 Gng2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Mapk9 Prkch Mapk8 Prkci Prkcb Prkcd Cacnb1 Prkce Prkca App Prkcz Mapk12 Mapk10 Mapk13 Mapk15 Mapk14 Kat5 Mapk7 Bace2 Bace1 Mapk11 Pkn2 Mapk1 Cacnb2 Cacna1f Cacna1d Pkn3 Klc1 Psen1 Adam17 Mapk3 Cacna1c Mapk6 Mapk4 Klc4 Psen2 Klc3 Klc2 Cacna1s Apba1 Apba2 Ncstn Apba3 Aph1b Pkn1 Prkcq Prkcg CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Mras Rasal2 Gab3 Egfr Phldb2 Nf1 Rras2 Dab2ip Sos2 Pebp4 Sos1 Spry2 Spry3 Shc1 Spry1 Spry4 Pebp1 Map2k6 Map3k4 Rras Mapk12 Mapk13 Mapk14 Stat5a Stat5b Map2k4 Stat3 Stat2 Stat1 Mapk11 Prkd3 Mapk1 Prkd1 Braf Prkd2 Map2k7 Pik3c3 Mapk3 Rac2 Map2k3 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Mapk9 Prkch Mapk8 Map3k5 Prkci Nras Prkcb Shc3 Prkcd Rasa2 Prkce Rasa1 Map3k3 Rasa4 Map3k2 Prkca Raf1 Grap Shc2 Erbb4 Pik3cg Prkcz Pik3cb Pik3cd Mapk10 Pik3ca Gab1 Gab2 Pik3c2b Pik3c2a Map2k2 Map2k1 Hras Stat6 Stat4 Pik3r5 Akt3 Akt2 Erbb2 Erbb3 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Mmp3 Fgg Plg Plat Mmp9 Mmp1a Plau Serpine1 Serpinf2 Plaur Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Drd4 Ppp1ca Gng3 Prkaca Gng4 Kcnk9 Epb41 Gng8 Snap29 Gnb1 Snap25 Gnb2 Flna Snap23 Gnb4 Gnai1 Gnb3 Prkx Prkacb Epb41l3 Drd1 Drd5 Ppp1cc Gnaz Adcy7 Prkar2a Prkar2b Gnai2 Stx3 Gng11 Gnai3 Slc6a3 Epb41l2 Kcnk3 Vamp8 Clic6 Ppp1r1b Vamp1 Vamp3 Slc18a2 Vamp2 Adcy2 Drd2 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Shh Smo Ptch1 Sufu Crebbp Stk36 Fbxw11 Btrc Gli1 Gli3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng3 Prkaca Gng4 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnai1 Gnb3 Gnb5 Prkar1a Prkar1b Slc5a7 Prkx Prkacb Gnao1 Prkar2a Prkar2b Gnai2 Kcnj9 Gng11 Kcnj6 Gnai3 Kcnj5 Chrm2 Chrm4 Gnat2 Gnat1 Adcy10 Slc18a3 Slc6a8 Kcnj3 Gng10 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gnpda1 Amdhd2 Gnpda2 Npl Gfpt1 Gfpt2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Ep300 Atf2 Map3k7 Rras Mapk12 Mapk13 Mapk14 Tab1 Mapk11 Mapk1 Mapk3 Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Jund Acvr1c Mapk9 Snip1 Mapk8 Lefty1 Nras Tgfb2 Tgfb3 Gdnf Acvrl1 Cited1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Skil Bmp7 Jun Gdf5 Bmp6 Bmp5 Gdf7 Bmp4 Bmpr2 Mapk10 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Bmp1 Smad4 Acvr2a Hras Smad9 Tll2 Tll1 Gdf15 Inhba Acvr2b Inhbb Junb Inhbc Tgfbr1 Smad5 Tgfbr2 Smad6 Gdf11 Inhbe Smad7 Gdf10 Crebbp BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Proz F2 Tfpi F3 F7 Thbd F8 F9 Pros1 F2rl3 Fgb Fga Fgg Plg Plat Itga2b Plau Plaur F2r Klkb1 Kng2 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Nras Gsk3b Gnaq Gngt2 Sos2 Gnb1 Sos1 Ptger1 Gnb2 Pik3r1 Foxo4 Gnb4 Gnai1 Gngt1 Gnb3 Pik3r2 Gnb5 Ywhaz Pik3r3 Pik3cb Pik3ca Casp9 Nos3 Insr Rps6kb2 Foxo1 Gnai2 Irs1 Gnai3 Gnat2 Pik3r5 Pdpk1 Akt1 Akt3 Gna11 Akt2 Gna14 Foxo3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Ep300 Creb3l4 Hrh1 Gng3 Creb3l1 Gng4 Gng7 Creb3l2 Gng8 Gngt2 Gnb2 Gngt1 Adora2b Adora2a Gng12 Adra2c Adra2b Htr6 Htr7 Prkar1a Oprl1 Prkar1b Phka1 Phka2 Prkacb Adrb2 Adra1b Grm1 Adra1a Grm5 Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Htr5a Phkb Adcy7 Chrm1 Prkar2a Oprd1 Chrm3 Prkar2b Chrm5 Htr1d Hrh4 Htr1f Hrh3 Gnai2 Adora1 Htr1b Adora3 Htr1a Gnrhr Grm3 Gnai3 Grm2 Htr4 Gys1 Gnal Gys2 Clta Cltb Adcy3 Cltc Mtnr1a Adcy4 Creb1 Adcy1 Creb3 Adcy8 Phkg1 Adcy5 Phkg2 Adcy6 Mtnr1b Adcy9 Pygb Kcnj3 Pygl Pygm Gpr50 Oprk1 Htr2a Htr2c Htr2b Adrb1 Hrh2 Adrb3 Grm4 Grm7 Grm8 Gsk3b Rap1a Rap1b Drd1 Drd5 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Gng2 Adcy2 Drd2 Drd4 Prkaca Gnb1 Gnai1 Gsk3a Crebbp Gng10 Creb3l3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Sos2 Sos1 Spry2 Spry3 Shc1 Spry1 Spry4 Pebp1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Mapk1 Map2k7 Pik3c3 Mapk3 Rac2 Map2k3 Akt1 Rac1 Plcg1 Araf Map3k6 Prkcq Frs2 Plcg2 Frs3 Prkcg Mapk9 Prkch Fgfr3 Mapk8 Map3k5 Prkci Fgfr4 Nras Fgfr1 Prkcb Fgfr2 Shc3 Prkcd Rasa2 Prkce Rasa1 Map3k3 Rasa4 Map3k2 Prkca Raf1 Ptpn6 Grap Pik3cg Prkcz Pik3cb Pik3cd Mapk10 Pik3ca Pik3c2b Pik3c2a Map2k2 Map2k1 Hras Akt3 Akt2 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Nags Asl Cps1 Otc Ass1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb1 Cnga3 Gnb2 Pdc Gnb4 Cnga1 Gngt1 Grk1 Gnb5 Pde6g Rho Gng12 Calml3 Rgs9 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gnat1 Gng10 Gng2 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk9 Mapk8 Pld2 Ywhaz Elk1 Psma4 Mapk12 Mapk10 Psma3 Psma6 Mapk15 Psma5 Mapk14 Ccne2 Psma2 Psma1 Sfn Cask Ywhah Ywhag Ywhae Ccne1 Th Ywhab Psmb10 Sncaip Mapk7 Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Mapk1 Septin4 Psmb3 Stx7 Septin2 Septin1 Stx12 Gpr37 Ndufv2 Mapk3 Psma7 Snca Slc6a3 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Prkch Prkci Gng3 Gng4 Prkcb Gng7 Gnaq Gng8 Prkcd Gngt2 Prkce Gnb1 Prkca Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Grin2a Slc5a7 Prkcz Grin1 Grin2d Grin2c Grin2b Chrm1 Chrm3 Pkn2 Gng11 Pkn3 Slc18a3 Plcb4 Gna11 Gng10 Gna14 Pkn1 Prkcq Prkcg OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gng3 Adcy7 Gng4 Oprd1 Gng7 Gng8 Gngt2 Gnai2 Gnb1 Gnb2 Gnb4 Gnai1 Gnai3 Gnb3 Gnb5 Gng12 Pdyn Penk Gng10 Gng2 Adcy2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Pola1 Rpa2 Top2b Prim1 Top2a Top1 Dna2 H3-3b Rfc5 Pold2 H3c8 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb Mcee Pcca Mmut DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Dscaml1 Rrm1 Adsl Rrm2 Nme3 Rrm2b Nme2 Ak1 Nme4 Gmps Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Nme1 Ak8 Atic Nme7 Nme6 Ppat Guk1 Gart VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Vdr Rara Gc F13b Rxra HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Plcb1 Gng3 Gng4 Rhoa Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Rap1a Gngt1 Gnb3 Adora2b Rap1b Itpr3 Adora2a Gng12 Itpr2 Itpr1 Oprl1 Grm1 Grm5 Sstr5 Sstr4 Sstr3 Drd1 Sstr2 Drd5 Sstr1 Oprm1 Gnao1 Rap1gap Chrm1 Oprd1 Rasgrp3 Chrm3 Rasgrp4 Chrm5 Rasgrp1 Rasgrp2 Arhgef1 Dnajc27 Adora1 Garnl3 Adora3 Gnrhr Bdkrb2 Grm3 Bdkrb1 Grm2 Gpr45 Chrm2 Chrm4 Cacna1a Clta Cacna1b Cltb Cltc Gng2 Oprk1 Prkcq Prkcg Drd2 Prkch Drd4 Prkci Prkcb Prkcd Prkce Prkca Gnb1 Prkcz Gng13 Cacna1e Grm4 Grm7 Grm8 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Cryab Mapk3 Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Frs2 Plcg2 Frs3 Prkcg Prkch Prkci Nras Fgfr1 Crkl Prkcb Sphk2 Arhgap1 Prkcd Prkce Sphk1 Prkca Pak1 Pik3r1 Raf1 Pik3r2 Pak3 Lpxn Pak2 Arhgap8 Pik3r3 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Wnt5a Pik3c2a Ptk2 Map2k2 Map2k1 Wnt5b Tgfb1i1 Hras Wnt10a Wnt10b Notch4 Notch1 Notch2 Akt3 Akt2 Fos Rhoc Gsk3b Rbpjl Rhoa Wnt7b Dvl1 Rhob Dvl2 Dvl3 Sos2 Sos1 Wnt7a Shc1 Wnt2 Wnt1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Rbpj Stat3 Wnt2b Map3k1 Stat1 Src Grb14 Fgf1 Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Pdgfd Efnb1 Jag2 Efnb2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 Apc2 Epha3 Mapk8 Ephb1 Dll1 Ephb2 Ephb3 Dll3 Dll4 Rasa1 Dlk1 Apc Pdgfrb Tek Pld1 Pdgfra Pld2 Pdgfa Pdgfb Grap Jun Nck2 Jak1 Nck1 Ctnnb1 F2r DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Adat2 Tyms Nme1 Dscaml1 Dut Rrm1 Dtymk Rrm2 Nme3 Rrm2b Nme2 Nme4 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stx1b Stx1a Snap25 Syt5 Syt3 Syt2 Syt1 Syt11 Syt12 Syt7 Syt6 Rab3a Stxbp1 Unc13c Unc13b Syt15 Stx2 Vamp1 Unc13d GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Srf Traf6 Itpr1 Elk1 Mef2d Map2k6 Hspb1 Prkacb Mapk14 Eif4e Map2k4 Mef2c Nfatc2 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Mapk3 Creb1 Adcy1 Akt1 Prkg1 Rac1 Plcg1 Araf Prkcq Prkch Prkcb Prkcd Prkce Prkca Pak1 Pik3r1 Raf1 Pxn Pik3cb Rock1 Cdh1 Ptk2 Map2k2 Map2k1 Ywhab Mapk7 Foxo1 Irs1 Elk4 Pdpk1 Foxo3 Fos Itgav Rps6ka3 Gsk3b Rhoa Rps6ka1 Sos1 Shc1 Atf2 Mmp3 Itgb1 Plau Bcl2l1 Crk Stat3 Src Bcar1 Ptk2b Casp3 Gng2 Slc18a2 Mapk9 Bax Mapk8 Bcl2 Prkaca Map3k14 Gnb1 Lyn Ppp3ca Arrb2 Jun Egr1 Nfkbia Jak2 Grb2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ctnnb1 Ryr1 Hbegf Ryr3 Nos1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Cd38 Ptgs2 Camk4 Odc1 Map2k5 Ptpn11 Tpcn1 Tpcn2 Bad Cck Gast Map3k11 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pkm Hk2 EG433182 Hk1 Pgk1 Pgam2 Pfkm Aldoa Gpi Pklr Bpgm Hkdc1 Eno2 Pfkl NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Rbpj Rbpjl Ncor2 Dll3 Cirsr Dll4 Dlk1 Maml1 Numb Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Abat Csad Gad1 Aldh5a1 Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Mapk9 Mapk8 Map3k5 Fas Daxx Faf1 Parp4 Parp3 Parp2 Parp1 Cflar Jun Lmnb1 Lmnb2 Gsn Casp6 Capg Mapk10 Lmna Casp9 Scin Dffb Map2k4 Apaf1 Fadd Fasl Casp8 Casp7 Casp3 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Plcb1 Myh7 Gng3 Gng4 Gng7 Gnaq Gng8 Myh11 Plcz1 Myh14 Plce1 Myh13 Gnb3 Myh10 Itpr3 Gng12 Itpr2 Itpr1 Prkx Prkacb Cxcr3 Cxcr4 Cxcr5 Cxcr6 Cxcl10 C5ar1 Gnao1 Fpr1 Ccr10 Ccr1 Nfatc4 Xcr1 Ccrl2 Nfatc3 Ltb4r2 Nfatc2 Rhog Gnai2 Fpr-s1 Ccr9 Ccr8 Mapk1 Ccr7 Gnai3 Ccr6 Nfatc1 Ccr5 Ccr4 Ccr3 Ccr2 Cx3cr1 Mapk3 Ifnar1 Camk2d Rac2 Ccl11 Adcy5 Ccl12 Akt1 Adcy6 Ccl7 Camk2a Rac1 Ccl5 Ccl4 Plcg1 Ccl3 Araf Ccl2 Pf4 Plcg2 Prex1 Cx3cl1 Col14a1 Nfat5 Ccl22 Nras Ccl20 Mylk2 Prkcb Mylk3 Prkce Pak1 Pak6 Raf1 Pak3 Pak2 Pak5 Arpc1b Pak4 Arpc1a Pik3cg Prkcz Mylk Pik3cb Pik3cd Arpc4 Pik3ca Rock1 Cask Ikbkb Ifng Acta1 Cxcr1 Acta2 Cxcr2 Actb Arpc3 Arpc2 Arpc5 Pdpk1 Akt3 Akt2 Col12a1 Rhoc Rhoa Sos1 Shc1 Itgal Actg1 Il2 Itgb7 Itgb1 Actbl2 Actc1 Rras Nfkb2 Col20a1 Arpc5l Rela Stat3 Relb Chuk Col6a1 Col6a2 Ptk2b Col6a3 Gng2 Jund Adcy2 Prkaca Vav1 Gnai1 Grap Jun Jak2 Kras Junb Myo3a Myo3b Plcb4 Myh1 Plcb3 Myh2 Myh3 Gna11 Gng10 Myh8 Gna14 Vwf Myh9 Plcd1 Plcb2 Myh4 Myh6 Plcd4 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Hprt1 Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Ep300 Grik2 Grik4 Grik3 Actg1 Tbp Grin2a Actbl2 Actc1 Grik5 Grik1 Grin1 Map2k4 Grin2d Arpc5l Taf4 Grin2c Grin2b Apaf1 Map3k10 Rhog Map2k7 Cltb Rac2 Casp8 Rac1 Casp3 Tubb2b Mapk9 Tubb2a Hip1 Bdnf Dync1h1 Ift57 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Arpc1b Ap2a2 Arpc1a Ap2a1 Tubb5 Hap1 Tubb6 Hip1r Jun Tubb3 Kalrn Tubb1 Htt Gapdhs Dync1li2 Dync2h1 Dync1li1 Dnai2 Tubb4b Dynll1 Tubb4a Dynll2 Capn9 Cyc1 Sp1 Capn5 Capn7 Capn6 Capn1 Capn3 Capn2 Dnah3 Dlg4 Dnah5 Cyfip2 Trp63 Dnah8 Acta1 Cyfip1 Acta2 Capns1 Actb Capn10 Actr2 Trp53 Capns2 Capn11 Trp73 Crebbp Arpc5 Fos ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Cs Pkm Pdha1 Pdha2 Pcx Me1 Clybl Pck1 Pklr Acly T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Mapk9 Irak1 Mapk8 Myd88 Tank Irf3 Tlr9 Tlr8 Tlr7 Tlr6 Tirap Tlr4 Tlr3 Tlr2 Traf6 Map3k7 Elk1 Jun Nfkbia Mapk14 Map2k2 Map2k1 Chuk Ikbkb Tab1 Mapk3 Map2k3 Map3k8 Ikbke Tbk1 Ticam2 Irak4 Ticam1 Ecsit Nfkbie Tollip VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Pdxk Psat1 Pnpo WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Tcf7l2 Wnt3 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Ppp3ca Arrb2 Arrb1 Ppp3cb Hdac1 Crebbp Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Ep300 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Nfatc1 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Prkcq Cdh15 Cdh13 Prkcg Cdh12 Prkch Cdh11 Prkci Cdh10 Prkcb Pcdh8 Pcdh7 Pcdh9 Prkcd Pcdhgb1 Prkce Pcdhga5 Pcdhga6 Prkca Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Prkcz Gsk3b Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Fbxw11 Btrc Tle3 Tle2 Tle1 Ctnna3 Ctnna2 Ctnna1 Tle6 Ppp3cc Bcl9 Csnk1g3 Hdac3 Hdac2 Csnk1g2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Sag Smarca2 Smarca1 Smarca4 Smarca5 Gng2 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Gnb1 Csnk1d Csnk1e Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp Hprt1 Aprt Ada Xdh TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gng3 Prkaca Gng4 Gng7 Gng8 Stx1b Gngt2 Cacnb1 Snap29 Stx1a Gnb1 Snap25 Gnb2 Snap23 Gnb4 Gnai1 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Gnao1 Prkar2a Prkar2b Gnai2 Gng11 Grm3 Gnai3 Grm2 Cacna1a Gnat2 Cacna1b Adcy10 Cacna1e Vamp8 Vamp1 Gng10 Vamp3 Vamp2 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnao1 Gng3 Adcy7 Gng4 Gng7 Gng8 Gngt2 Gnai2 Oxt Gnb1 Gnb2 Avp Gnb4 Gnai1 Gnai3 Gnb3 Gnb5 Gng12 Pdyn Gng10 Gng2 Oprk1 Adcy2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb1 Gnao1 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb1 Cnr1 Gnb2 Gng11 Gnb4 Gnai1 Gnai3 Gnb3 Cacna1a Cacna1b Cacna1g Grm1 Plcb3 Grm5 Plcb2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Ttf1 Rrn3 Polr1b Taf1a Psmc3ip Taf1b Polr1d Polr2k Cavin1 Tbp Ubtf Tbpl2 Tbpl1 Taf8 Taf1c PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pdxk Pnpo SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Tk1 Adat2 Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Prkaca Gng3 Adcy7 Prkar2a Gng4 Prkar2b Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 Prkx Prkacb Adrb2 Gng10 Gng2 Adcy2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng3 Prkaca Gng4 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnai1 Gnb3 Gnb5 Gng12 Prkx Prkacb Oprm1 Gnao1 Adcy7 Prkar2a Oprd1 Prkar2b Gnai2 Gnai3 Gnal Creb1 Pdyn Penk Gng10 Gng2 Adcy2 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb1 Prkcd Prkce Plce1 Prkca Adra2c Adra2b Itpr1 Adra2a Plcb4 Adra1b Plcb3 Adra1a Gna11 Plcb2 Prkcg LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 Pcx Sdhd ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Echs1 Mlycd Pcca Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkg Nfkbia Map3k1 Dusp1 Cd40lg Nfkb1 Chuk Tnfaip3 Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Plcb4 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Vac14 Becn1 Inpp1 Sacm1l Pik3cb Pik3r4 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Fbp1 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Pgm2l1 Gys1 Gaa Agl Ugp2 Pygl Amy1 Ugt3a2 Pgm1 Gpi Ugdh Gusb LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Cyp2c65 Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh Pcx D2hgdh Sdhd GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Hk1 Gpi Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Map2k7 Mapk3 Calm1 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Rasgrp1 Grb2 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 Nqo1 Nos3 Abcb1a CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Sds Gldc Aqp8 Asns Asrgl1 Amt Cps1 Dld Glul Gls2 Glud1 Hal TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Nfkbia Nfkb1 Prkcb Mapk3 Prkca Rela Itpr1 Plcb1 Map2k1 Raf1 Cacna1c Cacna1f Cacna1d Hras Mapk1 Cacna1s CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 Ins2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Hexa Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Vac14 Erbb2 Plcb1 Becn1 Synj1 Inpp4b Pik3c2a Pten Pik3r4 Pik3c3 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pip5k1a Pik3cd PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Tkt Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls Rpia Gpi Pfkl G6pdx Taldo1 Fbp1 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Srm Odc1 Mat2b ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Hagh Glo1 Ldhd FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk Pfkfb1 Gmds Pfkl Fbp1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Slc28a1 Ctps1 Rrm1 Rrm2 Tyms Rrm2b Cmpk1 Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Pdia2 Sdf2l1 Cyp2e1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Nqo1 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Dut Upb1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Echs1 Acat1 Hsd17b10 Acadl Hadh Acads Acaa2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 Abcb1a PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Dut Upb1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rbks Rpe Pgd Dera Aldob H6pd Prpsap1 Tktl1 Rpia Pfkm Fbp2 Gpi Taldo1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 Pklr Pfkm Gpi Hk2 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk Pfkfb1 Gmds Pfkl Fbp1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Gnb1 Creb1 Adcy2 Gngt1 Fshr Prkacb Cga Gng12 Ppp1ca AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Th Pnmt GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Abcc2 Slc22a1 Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Mapk8 Shc1 Map3k1 Elk1 Mapk3 Calm1 Rac1 Ppp3ca Jun Cd79b Ppp3cb Lyn Syk Orai1 Fos Blnk Nfat5 Map2k1 Lck Grb2 Raf1 Hras Prkcb Plcg1 Prkca GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gnb1 Tub Gngt1 Plcb1 Chrm1 Htr2c PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 Bpgm G6pc1 Pgam1 Pfkm Pgk1 Gpi ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Pdia2 Sdf2l1 Cyp2e1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Sult1e1 Sult2a1 Abcc4 Abcc5 Abcb1a Ugt2b36 Abcg2 Gstt1 Abcc1 Cyp2d22 Sult1a1 Cyp3a16 Cyp2a5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Sds Mmut Pcca Bckdha Pccb Dbt Dld Bckdhb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 Fpgs Mthfd1 Mthfd2 Ftcd Dhfr Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Aars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 Abcb1a FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Atp5f1d Uqcrc1 Atp5pb Atp5f1c Atp5f1b Atp5f1a Gpd2 Slc37a4 Slc25a4 Sdhd VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Nqo1 Ggcx Vkorc1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp3a16 Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Spcs1 Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Cyp3a16 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ippk Itpka Bpnt1 Ip6k1 Inpp4a Inpp5j Itpk1 Ipmk Nudt3 Minpp1 Impa1 Isyna1 Inpp4b BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Sqle Pmvk Fdps Hmgcr Acat1 Idi1 Mvd Mvk Fdft1 Lss BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Tpi1 Pkm Pfkp Gpi GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Fbp1 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pisd Pcyt1a Pla2g15 Lypla1 Chat Dgka Pemt Chka Agpat1 Ptpmt1 Gpd2 Pgs1 Gpam Gpd1 Crls1 Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Cdipt Phospho1 Pld2 Plpp1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfb C3 Cfd C5 C6 C9 Cfp C8a NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Acer2 Sptlc1 Cerk Sptlc2 Degs2 Enpp1 Gba1 Samd8 B4galt2 Sphk2 Gla Ugcg Sdr16c5 Ugt8 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod3 Sod2 Tyrp1 Cat NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcg2 Bche Pdia2 Sdf2l1 Abcc1 Ces2h Abcc2 Hyou1 Ces1d Top1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp3a16 Abcb1a BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Sdhc Hk1 Sdhb Sdha Cs EG433182 Idh3g Mpc1 Mdh1 Pgd Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Aco1 Bpgm H6pd Tktl1 Rpia Pfkm Gpi Taldo1 Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 Ireb2 Gsr Pkm Glud1 Sdhd PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 Abcb1a METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Shc1 Mapk3 Plcg1 Prkca Socs1 Irs1 Insr Ptpn6 Ghr Stat5a Map2k1 Stat5b Rps6ka1 Slc2a4 Grb2 Raf1 Sos1 Jak2 Hras Mapk1 Ins2 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 Slc14a2 Atp1a2 Atp1a1 Aqp3 Aqp2 Atp1a3 Atp6v1b1 Ca1 Slc4a1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Vac14 Pik3r4 Prex1 Pik3c3 Inpp5f Ptpmt1 Plce1 Inppl1 Zfyve16 Pik3cd XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Vars1 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Faf1 Jun Arhgdib Map3k7 Pak1 Ripk2 Prkdc Fasl Parp1 Cflar Pak2 Ptpn13 Lmnb1 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Map2k4 Lmna Fas Fadd Dffa Daxx Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcg2 Abcc1 Tuba1b Abcc2 Tubb1 Slco1b2 Abcb1a PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Gpt Aars2 Mpc1 Pcx HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Tpi1 Rpe Rpia G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Prkca Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Ptges Ptgis Pdia2 Cyp2c65 Sdf2l1 Cyp2e1 Hyou1 Ephx2 Pdia6 Ptgs1 Pdia4 Alox12b Ppib Ptgs2 Slc22a6 Dnajb11 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Alox12 Prxl2b Cyp2u1 Ugt1a2 Alox5 Slc22a8 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Aqp1 Slc3a2 Slc7a6 Slc7a7 Slc4a4 Slc9a1 Slc7a5 Slc7a8 Slc7a9 Slc6a20a Ca1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Mapk8 Shc1 Elk1 Mapk3 Plcg1 Jun Fos Ptpn6 Epo Epor Stat5a Map2k1 Grb2 Raf1 Sos1 Jak2 Hras CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Tkt Aldob Rpe Rpia Prps1 Pgm1 Dera Gpi Pfkl Pgls G6pdx Fbp1 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Dpys Gad1 Dpyd Aoc3 Aldh6a1 Aldh2 Cndp1 Abat Upb1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Cacna1a Slc2a2 Cacnb1 Adcy10 Prkca Vamp2 Rab3a Rapgef4 Gng2 Glp1r Gnaq Camkk1 Gnb1 Itpr3 Plcb1 Abcc8 Cacna2d2 Chrm3 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Gnb1 Creb1 Htr6 Gngt1 Prkacb Ppp1ca METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin1 Cyp2c65 Cyp3a13 Cyp3a16 Oprm1 Cyp2d22 Cyp2c50 Grin2a Cyp2b10 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Mat2a Ahcy Mettl6 Scly Slc39a8 Sephs2 Cbs Papss1 Cth Mars1 Ggt1 Mat2b GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gnb1 Adcy2 Gngt1 Prkacb Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Hkdc1 Hk1 Pgm2 Gys1 Gpi Gbe1 Ganab PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Tat Fah Pah Hpd Il4i1 Gstz1 Farsa Farsb Hgd Got1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Gng2 Gnb1 Itpr1 Plcb1 Akt1 Srf Adcy1 Rock1 Lpar4 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Hexa Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex14 Crat Pex13 Crot Cpt2 Pex11g Abcd2 Slc25a20 Acsl1 Abcd1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Ugt2b38 Cyp19a1 Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Nars1 Adss1 Ddo Il4i1 Aspa Dars1 Gad1 Ass1 Cad Asns Asrgl1 Adsl Asl Abat CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Nfkbia Rela Itpr1 Plcb1 Map2k1 Nfkb1 Prkcb Raf1 Mapk3 Prkca Hras Mapk1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Mif Dbh Fah Tyr Cyp2e1 Comt Dct Aldh1b1 Aldh2 Acss2 Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Acss1 Got1 Haao Cat GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Shc1 Gh Mapk3 Plcg1 Prkca Irs1 Ptpn6 Ghr Stat5a Map2k1 Stat5b Rps6ka1 Slc2a4 Grb2 Raf1 Jak2 Hras Mapk1 Ins2 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Gpt Aars2 Mpc1 Pcx MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Echs1 Mlycd Pcca Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Galt Uxs1 Ugp2 Gale Pgm1 Galk1 Ugdh Gck PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Plcb1 Akt1 Plcg1 Pik3cg Pik3r6 Prkca Vav1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Ppargc1a Rora Sirt1 Nmnat3 Nmnat2 Nadk Npr1 Clock Nqo1 Nmnat1 Nampt CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Hmbs Cpox Urod Gusb Fech Uros Hmox1 Cox10 Flvcr2 Blvra Ppox Alas1 Alad Ftmt Cox15 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Gnb1 Creb1 Htr7 Gngt1 Prkacb Ppp1ca PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Hk1 Tpi1 Slc2a1 EG433182 Pkm Pgam2 Galm Pfkp Pgam1 Gpi STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Prkar1b Kcnh2 Kcnj4 Prkar2a Chrm2 Prkar2b Prkacb Kcnk1 Atp1b4 Kcnq1 Mcu Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Slc9a1 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Chrna3 Cyp2b10 Cyp2a5 Ugt1a9 Fmo3 Chrnb2 Ugt1a5 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Glyctk Akr1b1 Plpp2 Gpam Gpd1 Aldh3a1 Agpat1 Lipc Gpd2 Lpl Plpp1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Abcc4 Entpd5 Abcc5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Aox1 Pfas Atad1 Gucy1a2 Adk Atic Tpmt Ppat Nme6 Slc29a2 Ampd1 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Ak1 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Abcc4 Entpd5 Abcc5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Aox1 Pfas Atad1 Gucy1a2 Adk Atic Tpmt Ppat Nme6 Slc29a2 Ampd1 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Gclc Gclm Mpst Ctns Cdo1 Cars1 Cth Got1 Ldha MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Stat1 Mapk8 Shc1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Map2k4 Prkcb Plcg1 Prkca Srf Sos1 Rasa1 Egfr Stat6 Jak1 Egf Stat3 Stat2 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 Fpgs Mthfd1 Mthfd2 Ftcd Dhfr Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk Pfkfb1 Gmds Pfkl Fbp1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxk Alpl Pdxp Pnpo Aox1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Hk1 Galt Uxs1 Galk2 Ugp2 Gale Pgm1 Ugdh EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Slc28a1 Ces1d Tyms Tymp Cda DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Tyr Flad1 Enpp1 Rfk Acp1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Ugt2b36 Cacna1a Ugt2b1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Ugt1a2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Echs1 Acat1 Hsd17b10 Acadl Hadh Acads Acaa2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Agpat1 Gnpat Cept1 Agps Plpp1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Bpnt1 Chst11 Sult2b1 Papss2 Suox CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Ak1 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Slc2a2 Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Gck Treh PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Maob Slc6a4 Cyp3a13 Cyp2d22 Cyp2c50 Maoa Aox1 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc2a2 Gpt2 Slc25a22 Gpt Slc2a4 Slc1a4 Glud1 Slc38a4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Slc28a1 Ctps1 Rrm1 Rrm2 Tyms Rrm2b Cmpk1 Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Sdhc Sdhb Sdha Cs Dhtkd1 EG433182 Idh3g Pgam2 Pdha1 Pklr Suclg1 Mpc1 Mdh1 Pgd Suclg2 Fh Pgls Idh1 Idh3a Ldha Dlst Pdhb Idh3b Aldob Aco2 Aco1 Dlat Dld Rpia Pgk1 Gpi Pfkl G6pdx Taldo1 Tkt Slc2a2 Slc1a5 Hk2 Slc16a1 Pkm Gls2 Glud1 Pcx Sdhd ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Hexa Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Sdhb Sdha Cs Dhtkd1 EG433182 Suclg1 Mpc1 Mdh1 Pgd Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Tktl2 Aco1 Pdha2 Dlat Slc16a4 Dld Slc1a2 Rpia Pgk1 Gpi G6pdx Taldo1 Hk2 Slc2a1 Pkm Pfkp Gls2 Glud1 Pcx HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Hexa Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Ebp Sc5d Cyp51a1 Hsd17b7 Dhcr7 Msmo1 Lbr Nsdhl Dhcr24 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Mtor Tyk2 Jak1 Mapk1 Stat3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Impa1 Isyna1 Vac14 Becn1 Synj1 Plcb4 Pik3c3 Cct3 Ptpmt1 Pik3ca Bpnt2 Ipmk ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Casp9 Bcl2l1 Pld1 Ralbp1 Rhoa Ralgds Smad3 Smad4 Akt1 Elk1 Apaf1 Chuk Foxo4 Mapk3 Rac1 Map2k1 Raf1 Pik3ca Hras Vav3 Rala Bad PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gng2 Gnaq Cyp11b2 Cyp11a1 Gnb1 Agtr1a Hsd3b6 Cyp21a1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Tkt Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls Rpia Gpi Pfkl G6pdx Taldo1 Fbp1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Th Pnmt ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcg2 Egfr Abcb1a NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Gclc Gclm Mpst Ctns Cdo1 Cars1 Cth Got1 Ldha ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Gng2 Gnb1 Itpr1 Plcb1 Akt1 Srf Adcy1 Rock1 Lpar5 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Cyp2c65 Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Mapk8 Shc1 Akt1 Pik3cg Pik3r6 Irs2 Map2k2 Pdpk1 Foxo1 Irs1 Insr Map2k1 Slc2a4 Grb2 Raf1 Sos1 Hras Mapk1 Ins2 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Lars1 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Impa1 Isyna1 Ppip5k1 Synj1 Ip6k1 Bpnt2 Ipmk Nudt3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex14 Crat Pex13 Crot Cpt2 Pex11g Abcd2 Slc25a20 Acsl1 Abcd1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Impa1 Vac14 Plcd4 Becn1 Synj1 Pik3r4 Pik3c3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Adcy2 Prkacb Drd1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Ephx1 Cyp2c65 Cyp3a13 Cyp3a16 Cyp2c50 Cyp2b10 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Apaf1 Pcna Ccne1 Cdkn1a Ccnd1 Gadd45b Cdk4 Cdk2 Bax Bcl2 Rb1 Cdk1 E2f1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C1rb C1qa Serping1 Masp2 C2 C4a C1s2 Mbl2 C1qc C3 Cfd C5 C6 C9 C8a Cfb C1qb MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Psmc6 Psma3 Ubc Psmc5 Psma6 Psma5 Psmc2 Psmc1 Psma2 Psmc4 Psma1 Psmc3 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Glyctk Akr1b1 Plpp2 Gpam Gpd1 Aldh3a1 Agpat1 Lipc Gpd2 Lpl Plpp1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Mapk8 Map3k1 Elk1 Map2k7 Calm1 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Cga Gnrhr Prkcb Hbegf Camk2a Erbb4 Adcy5 Cdc42 Prkca Egr1 Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Itpr1 Plcb1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Cyp3a16 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Hk1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Gmppb Aldob Khk Phpt1 Pfkfb1 Fcsk Gmds Fpgt Gfus Pfkl Fbp1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Slc2a1 EG433182 Pkm Pfkp Gpi Hk2 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Mapk8 Shc1 Map3k1 Elk1 Mapk3 Rac1 Vav1 Ppp3ca Jun Cd79b Ppp3cb Lyn Syk Orai1 Fos Blnk Map2k1 Grb2 Raf1 Hras Prkcb Plcg1 Prkca Cd79a Nfatc4 Sos1 Nfatc1 Nfatc3 Nfatc2 Ppp3cc Btk LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Gng2 Gnb1 Itpr1 Plcb1 Akt1 Srf Adcy1 Rock1 Lpar1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Bdh1 Oxct1 Acat1 Hmgcl ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Nars1 Adss1 Ddo Il4i1 Aspa Dars1 Gad1 Ass1 Cad Asns Asrgl1 Adsl Asl Abat LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Top2a Mpo Cyp3a16 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Pcyt2 Pemt Chka Cept1 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Plcd1 Itpka Miox Ptpmt1 Pi4ka Itpk1 Minpp1 Impa1 Isyna1 Vac14 Becn1 Synj1 Inpp1 Sacm1l Pik3r4 Cct3 Pik3ca Ambra1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Top2a Cad Gzmb Hmgb2 Dffa Endog Casp7 Casp3 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkaca Gnb1 Gngt1 Prkar1b Prkar2a Prkar2b Prkacb Adcy10 Prkar1a GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Kars1 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Rbks Tktl2 Pfkp Rpe Rpia Prps1 Pgm1 Dera Gpi G6pdx Taldo1 Fbp1 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Hk1 Gpi Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1rb C1qa C2 C4a C1s2 C1qc C3 C5 C6 C9 C1qb C8a GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Tpi1 Slc2a2 Aldob EG433182 Bpgm Pkm Pgam2 Galm Pgam1 G6pc1 Pfkm Gpi FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Hk1 Aldoa Sord Pfkfb2 Fbp1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 Ins2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Hk1 Gpi Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Hmbs Cpox Urod Gusb Fech Uros Hmox1 Cox10 Flvcr2 Blvra Ppox Alas1 Alad Ftmt Cox15 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Hmbs Cpox Urod Gusb Fech Uros Hmox1 Cox10 Flvcr2 Blvra Ppox Alas1 Alad Ftmt Cox15 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Hk1 Sord Pfkfb2 Gpi ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Top2a Mpo Pdia2 Sdf2l1 Hyou1 Ptgs1 Pdia6 Pdia4 Ptgs2 Ppib Dnajb11 Top2b Erp29 Ugt1a1 Hspa5 Abcc3 Cyp3a16 Abcb1a IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Slc22a1 Grb2 Sos1 Pik3r1 Jak2 Bad Abcb1a SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Hexa Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Aanat Aldh2 Afmid Tph1 Kmo Inmt Wars2 Wars1 Tdo2 Aadat Kynu Cyp1a1 Acmsd Ido1 Ddc Haao Cat LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis COAGULATION%SMPDB%SMP0000586 Coagulation F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cyp2e1 Aldh1b1 Aldh2 Acss1 Acss2 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Glyctk Akr1b1 Plpp2 Gpam Gpd1 Aldh3a1 Agpat1 Lipc Gpd2 Lpl Plpp1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Gars1 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Akr1b1 Hk1 Galt Gaa Ugp2 Glb1 Lct B4galt1 G6pc1 Gale Pgm1 Gla BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Ebp Sc5d Cyp51a1 Hsd17b7 Dhcr7 Msmo1 Lbr Nsdhl Dhcr24 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Tat Fah Pah Hpd Il4i1 Gstz1 Farsa Farsb Hgd Got1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcg2 Abcc1 Tuba1b Abcc2 Tubb1 Slco1b2 Abcb1a SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Sirt1 Nmnat3 Trp53 Nmnat2 Nadk Aifm2 Cd38 Nqo1 Nmnat1 Nampt OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Pdhb Me1 Slc7a7 Idh3b Aco2 Dlat Dld Mycbp Slc38a5 Got2 Slc1a5 Slc1a4 Acly Slc16a1 Gls2 Glud1 Pcx Sdhd PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Tpi1 Rpe Rpia KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Slc12a1 Atp1a2 Clcnkb Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 Fpgs Mthfd1 Mthfd2 Ftcd Dhfr Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Th Pnmt SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Bcar1 Nfkbia Cxcr4 Gnai1 Gngt1 Nfkb1 Crk Mapk3 Plcg1 Ptk2b Gnaq Gnb1 Map2k1 Raf1 Cxcl12 Hras Pxn Mapk1 Pik3c2g Ptk2 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ace Agt Agtr1a DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Aox1 Atp1b2 Cyp2c50 Grin2a Maoa Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Hk1 Tpi1 Aldob Aldoc Pfkm Fbp2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Gpt Aars2 Mpc1 Pcx TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Ikbkg Mapk8 Nfkbia Map2k4 Map3k1 Casp2 Ripk1 Tank Nfkb1 Tnf Chuk Map2k6 Map2k7 Map4k2 Map2k3 Tradd Cradd Traf2 Jun Ikbkb Mapk14 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcb1 Akt1 Plcg1 Pik3r6 Prkca MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Echs1 Hadha Hadhb Acadl Hadh Cpt2 Slc25a20 Acaa2 Cpt1a Acsl1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Impa1 Isyna1 Ppip5k1 Inpp1 Itpka Inpp4a Nudt4 Ipmk Ip6k2 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Tpi1 Slc2a2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Pank3 Aldob Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Cacnb1 Atp1b1 Fmo3 Atp1b3 Aox1 Atp1b2 Grin2a Cyp2b10 Cyp2a5 Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Hmbs Cpox Urod Gusb Fech Uros Hmox1 Cox10 Flvcr2 Blvra Ppox Alas1 Alad Ftmt Cox15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Ftcd Aldh2 Cndp1 Hal Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Aldh3a1 Carns1 Hars2 Maoa Aoc1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Iars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Mdh2 Got2 Slc25a11 Slc25a12 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Dut Upb1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Mat2a Chdh Sardh Bhmt Shmt1 Mat2b Aldh7a1 Slc44a1 Gnmt Slc44a2 Mtr Dmgdh Shmt2 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway Masp2 C2 C4a Mbl2 C3 C5 C6 C9 C8a FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca Fasn CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Slc28a1 Ces1d Tyms Tymp Cda L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rars1 Rpl32 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Dpys Gad1 Dpyd Aoc3 Aldh6a1 Aldh2 Cndp1 Abat Upb1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Top2a Mpo Cyp3a16 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Me1 Pdhb Slc25a11 Pdha1 Acly Mdh1 Mpc1 Pcx CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Pon1 P2ry12 Cyp3a16 Cyp2c50 Cyp1a2 Cyp2b10 Abcb1a CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 Ins2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Echs1 Mecr Ppt1 Hadha Hsd17b10 Hadhb Acaa2 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Dut Upb1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Mapk8 Gab2 Il13 Pla2g4a Fcer1a Il4 Il5 Map2k7 Kras Pdk1 Ms4a2 Nras Fyn Fcer1g Rac1 Csf2 Lcp2 Lyn Syk Map2k1 Grb2 Raf1 Pik3r1 Lat Pik3ca Hras Mapk1 Vav3 Map2k4 Akt1 Tnf Map2k6 Map2k3 Plcg1 Prkca Map2k2 Inpp5d Sos1 Mapk14 Btk DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rbks Rpe Pgd Dera Aldob H6pd Prpsap1 Tktl1 Rpia Pfkm Fbp2 Gpi Taldo1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh Pcx Sdhd PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Rbks Rpe Pgm1 Dera Pgls Prps2 Tktl2 Pfkp Rpia Gpi G6pdx Taldo1 Fbp1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Ikbkg Creb1 Plcb1 Nfkb1 Mapk3 Ikbkb Prkca Mapk1 Nos3 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Spcs1 Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Nars1 Adss1 Ddo Il4i1 Aspa Dars1 Gad1 Ass1 Cad Asns Asrgl1 Adsl Asl Abat ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Csad Gad1 Ado Cdo1 Ggt6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Abcc4 Entpd5 Abcc5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Aox1 Pfas Atad1 Gucy1a2 Adk Atic Tpmt Ppat Nme6 Slc29a2 Ampd1 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Fbp1 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Hoxb9 Btg2 Trp53 Btg1 Prmt1 Ccnd1 Ngf Fgf1 Rb1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 Ins2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Kcnq4 Trpc3 Kcnq3 Kcnq2 Adcy10 Gucy1a2 Trpv4 Prkg2 Prkg1 Gucy1b1 Gucy1a1 Trpc7 Nos3 Kcnq5 Trpc4 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Abcg2 Pcyt1a Pcyt2 Abcc1 Slc22a3 Abcc2 Chpt1 Slc22a2 Sult1a1 Abcc3 Slc22a1 Cmpk1 Dck Pgk1 Nme1 Nt5c Abcc4 Abcb1a VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Slc6a2 Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 Abcb1a GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Galt Uxs1 Ugp2 Gale Pgm1 Galk1 Ugdh Gck ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Top2a Mpo Pdia2 Sdf2l1 Hyou1 Ptgs1 Pdia6 Pdia4 Ptgs2 Ppib Dnajb11 Top2b Erp29 Ugt1a1 Hspa5 Abcc3 Cyp3a16 Abcb1a OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Hk1 Gpi Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Slc2a1 As3mt Gsto1 Aqp9 Slc2a4 Aqp7 Pnp TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Tat Fah Pah Hpd Il4i1 Gstz1 Farsa Farsb Hgd Got1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Impa1 Isyna1 Ppip5k1 Inpp1 Synj1 Inpp4b Itpka Ip6k1 Itpk1 Nudt3 Minpp1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl11 Rps3 Rps25 Sars1 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Gng2 Gnb1 Itpr1 Plcb1 Akt1 Srf Adcy1 Rock1 Lpar2 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Fgfr1 Fgfr2 Klb Slc10a2 Fgf15 Nr1h4 Fgfr3 Fgfr4 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Hk1 Tpi1 EG433182 Galm Pgk2 Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Pfkp Pgam1 Gpi PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Cacna1a Slc2a2 Gcg Snta1 Sntb2 Sntb1 Abcc8 Cacnb1 Cacna2d2 Scn5a FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Hk1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Gmppb Aldob Khk Phpt1 Pfkfb1 Fcsk Gmds Fpgt Gfus Pfkl Fbp1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex14 Crat Pex13 Crot Cpt2 Pex11g Abcd2 Slc25a20 Acsl1 Abcd1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Gnb1 Ptgir Adcy2 Gngt1 Myl3 Mylk Prkacb CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkg Tab2 Mapk8 Nfkbia Tlr6 Map3k1 Cd14 Tab1 Tlr5 Nfkb1 Tirap Chuk Tlr4 Tlr3 Tlr2 Map3k7 Rela Map2k4 Ecsit Tollip Irak1 Myd88 Ikbkb Ly96 Tlr1 Mapk14 Tlr9 Tab3 Traf6 Tlr8 Tlr7 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcg2 Bche Pdia2 Sdf2l1 Abcc1 Ces2h Abcc2 Hyou1 Ces1d Top1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp3a16 Abcb1a RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rbks Rpe Pgd Dera Aldob H6pd Prpsap1 Tktl1 Rpia Pfkm Fbp2 Gpi Taldo1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Enpp1 Vnn1 Ppcs Ppcdc Coasy Pank1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Tkt Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls Rpia Gpi Pfkl G6pdx Taldo1 Fbp1 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Mapk8 Nfkbia Map3k1 Nfkb1 Elk1 Chuk Map2k7 Atf2 Adora2a Arhgef7 Jun Braf Map3k4 Pak1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Mapk11 Pik3ca Hras Mapk1 Creb1 Gngt1 Akt1 Prkacb Map2k6 Map2k2 Pdpk1 Gnb1 Rps6ka1 Ikbkb Bad ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 Fpgs Mthfd1 Mthfd2 Ftcd Dhfr Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Echs1 Mlycd Pcca Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Echs1 Mecr Ppt1 Hadha Hsd17b10 Hadhb Acaa2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhc Sdhb Sdha Cs Dhtkd1 EG433182 Pgam2 Pklr Suclg1 Mpc1 Mdh1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Rpia Pgk1 Slc1a3 Gpi Pfkl G6pdx Taldo1 Tkt Gls Hk2 Slc16a1 Pkm Glud1 Sdhd PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Galt Uxs1 Ugp2 Gale Pgm1 Galk1 Ugdh Gck PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Aars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 Abcb1a QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Nudt11 Prex1 Inppl1 Ipmk ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Pcx Sdhd TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Ftcd Aldh2 Cndp1 Hal Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Aldh3a1 Carns1 Hars2 Maoa Aoc1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a16 Cyp2c50 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Echs1 Hadha Hadhb Hadh Acsm1 Acadm Slc25a20 Acaa2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Bpnt1 Chst11 Sult2b1 Papss2 Suox ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Cyp19a1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Cyp11b1 Hspa5 Hsd11b1 Akr1d1 Srd5a1 Hsd17b3 Akr1c6 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Cyp2c65 Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 Pcx Sdhd BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa Kdr NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rbks Rpe Pgd Dera Aldob H6pd Prpsap1 Tktl1 Rpia Pfkm Fbp2 Gpi Taldo1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Cyp3a16 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Pcyt2 Chka Cept1 Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Hk1 Tpi1 EG433182 Galm Pgk2 Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Pfkp Pgam1 Gpi LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Ippk Itpka Plcd3 Miox Ptpmt1 Inpp4a Pi4ka Itpk1 Ipmk Pikfyve Minpp1 Impa1 Isyna1 Vac14 Becn1 Inpp1 Pik3r4 Pik3c3 Fig4 Pik3ca Ambra1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Ugt1a2 Hadha Ivd Hsd17b10 Hadhb Cyp2b10 Ehhadh Cyp2a5 Acsm1 Acadsb PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Dars1 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Slc2a2 Lct Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 Sntb2 Sntb1 Scn5a LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp3a16 Abcc10 Cyp2d22 Cyp2b10 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Egfr Erbb4 Erbb3 Prkca Psen1 Nrg2 Adam17 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Pld1 Ralbp1 Map3k1 Cap1 Ccnd3 Wasf1 Rac1 Cfl1 Ppp1r12b Actb Cdk5 Pak1 Myl2 Limk1 Arfip2 Pcna Mylk Pdgfra Cdkn1a Ccnd1 Vav3 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 Bpgm G6pc1 Pgam1 Pfkm Pgk1 Gpi METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Hk1 Gpi Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Ikbkg Nfkbia Map3k1 Tab1 Nfkb1 Chuk Tlr4 Ubc Map3k7 Camkk1 Rela Ripk1 Fadd Tnf Tradd Tnfrsf1b Tnfrsf1a Ncoa3 Irak1 Camkk2 Myd88 Ikbkb Il1a Il1r1 Map3k14 Traf6 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Slc6a2 Grin1 Slc6a4 Cyp2c65 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a Cyp2b10 Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads1 Fads2 Elovl4 Elovl5 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Hmbs Cpox Urod Gusb Fech Uros Hmox1 Cox10 Flvcr2 Blvra Ppox Alas1 Alad Ftmt Cox15 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Ugt2b38 Cyp19a1 Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Mat2a Chdh Aldh7a1 Ahcy Pemt Bhmt Mat2b Mtr BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Spcs1 Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Cars1 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 Stat5a Grb2 Sos1 Pik3r1 Jak2 Bad PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Gpt Aars2 Mpc1 Pcx CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Abcg2 Cyp2c65 Ces2h Abcc2 Ces1d Cyp3a16 Impdh1 Slco1b2 Ugt1a9 Abcb1a RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Mif Dbh Fah Tyr Comt Dct Gstz1 Aldh3a1 Ddc Maoa Pnmt Aoc1 Hgd Got1 Haao CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tpo Duox1 Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Tpi1 Pmm2 Tgds Amigo3 Mpi Akr1b1 Sord Aldob Khk Phpt1 Pfkfb1 Fcsk Fpgt Gfus Pfkl Fbp1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 Bpgm G6pc1 Pgam1 Pfkm Pgk1 Gpi ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Cacna1a Slc2a2 Abcc8 Cacnb1 Cacna2d2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Akt1 Pik3cg Pik3r6 Tsc2 Irs2 Eif4ebp1 Tsc1 Eif4e Irs1 Mtor Insr Slc7a5 Ins2 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Akr1b1 Pts Gchfr Dhfr Cbr1 Qdpr Gch1 Spr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Bdh1 Oxct1 Acat1 Hmgcl BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Hif1a Il1b Sirt3 Nlrp3 P4ha3 Tlr4 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a16 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Oprk1 Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Gnb1 Creb1 Gngt1 Prkacb Htr4 Ppp1ca ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Pdia2 Sdf2l1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp1a1 Sult1e1 Hsd17b1 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Plcd1 Ippk Itpka Miox Bpnt1 Ptpmt1 Inpp4a Inpp5j Itpk1 Ipmk Minpp1 Impa1 Isyna1 Vac14 Becn1 Sacm1l Pik3r4 Pik3c3 Cct3 Ambra1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Ikbkg Tab2 Mapk8 Nfkbia Map3k1 Cd14 Tab1 Nfkb1 Tirap Elk1 Chuk Tlr4 Tlr3 Tlr2 Jun Map3k7 Fos Rela Eif2ak2 Ppara Map2k4 Map2k6 Map2k3 Ecsit Tollip Irak1 Myd88 Ikbkb Ly96 Mapk14 Tlr9 Traf6 Tlr7 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Mapk3 Ubc Pik3cg Fyn Rac1 Vav1 Ppp3ca Jun Ppp3cb Fos Rela Map2k1 Lck Rasgrp1 Grb2 Zap70 Raf1 Cd3e Pik3r1 Lat Pik3ca Hras Map2k4 Prkcb Plcg1 Prkca Nfatc4 Sos1 Nfatc1 Nfatc3 Nfatc2 Ppp3cc MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Xdh Gmps Hprt1 Rac1 Aox1 Adk Tpmt Ppat Slc29a2 Slc28a2 Impdh1 Abcc4 Abcc5 Slc28a3 Slc29a1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Srm Msrb2 Il4i1 Dnmt1 Bhmt Mtap Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Dut Upb1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin1 Itpr1 Nos1 Prkacb Xdh Grin2a Dlg4 Aldh2 Prkca Ppp3ca METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Sdhc Hk1 Sdhb Sdha Cs Dhtkd1 EG433182 Pgam2 Pdha1 Suclg1 Mpc1 Mdh1 Pgd Suclg2 Fh Pgls Idh1 Idh3a Dlst Pdhb Tktl2 Aco1 Dlat Slc16a4 Dld Rpia Pgk1 Gpi G6pdx Taldo1 Gls Slc2a1 Pkm Pfkp Glud1 Pcx Sdhd TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxk Alpl Pdxp Pnpo Aox1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Gad1 Qars1 Gss Cad Gsr Ppat Ears2 Gclc Gclm Cps1 Glul Gls2 Glud1 Abat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Vac14 Erbb2 Plcb1 Becn1 Synj1 Inpp4b Pik3c2a Pten Pik3r4 Pik3c3 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pip5k1a Pik3cd ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Gclc Gclm Mpst Ctns Cdo1 Cars1 Cth Got1 Ldha BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slc10a2 Gpbar1 Slco1a4 Abcc4 Nr1h4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex14 Crat Pex13 Cpt2 Phyh Abcd2 Aldh2 Slc25a20 Acsl1 Hacl1 Abcd1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Tpi1 Aldoa Mdh2 Pank4 EG433182 Slc25a11 Pgam2 Galm Mpc1 Hk2 Pck1 G6pc1 Gpi Fbp1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 Grin2a Kcnd2 Scn1b Cacna2d2 Chrnb2 Pomc Drd1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Acat1 Pdha1 Acaca Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Pck1 Dlat Dld Pcx TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Hibadh Ivd Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Glb1 Kdsr Sgpp2 Sptlc1 Cerk Sptlc2 Degs2 Gba1 Sphk2 Gla Ugcg Acer1 Arsa Plpp1 Ugt8 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Akr1c6 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Glyctk Sardh Psph Sars1 Agxt Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Gars1 Psat1 Phgdh Maoa Gcat Gnmt Alas1 Srr Dmgdh Shmt2 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 Pklr Pfkm Gpi Hk2 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gnb1 Gngt1 Prkacb Mc2r Pomc GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Hk1 Gpi Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Cyp2c65 Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin1 Nos1 Prkacb Grin2a Calm1 Dlg4 Prkca Ppp3ca AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Mapk8 Shc1 Map3k1 Elk1 Map2k7 Prkcb Mapk3 Plcg1 Erbb4 Prkca Jun Fos Stat5a Map2k1 Srf Grb2 Raf1 Rasa1 Jak2 Hras Egf Stat3 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Gng2 Gnb1 Akt1 Srf Adcy1 Rock1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Hk1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Gmppb Aldob Khk Phpt1 Pfkfb1 Fcsk Gmds Fpgt Gfus Pfkl Fbp1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Hk1 Gpi Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 Pklr Pfkm Gpi Hk2 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc Glud1 Got1 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Lipa Cyp7a1 Cyp7b1 Akr1c6 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Hk1 Tpi1 Aldob Aldoc Pfkm Fbp2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Hars1 Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Tkt Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls Rpia Gpi Pfkl G6pdx Taldo1 Fbp1 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d22 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhcgr Gnb1 Creb1 Adcy2 Gngt1 Lhb Prkacb Cga Ppp1ca LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Slc2a2 Lct Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Slc25a11 Pgam2 Galm Mpc1 Pgm1 Hk2 Pank1 Slc37a4 Ldha Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Glyctk Akr1b1 Plpp2 Gpam Gpd1 Aldh3a1 Agpat1 Lipc Gpd2 Lpl Plpp1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Tpi1 Pkm Pfkp Gpi PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Fbp1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck Ugp2 Mgam Gpi Gbe1 Gys2 Sis TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Gpam Lpin1 Gpd1 Dgat1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Gng2 Gnaq Gnb1 Ace Agt Agtr1a CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Dpys Gad1 Dpyd Aoc3 Aldh6a1 Aldh2 Cndp1 Abat Upb1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Agl Ugp2 Pygl Gpi Ugt2b1 Ugdh Amy2a5 Gusb Hk2 Gck 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dlst Aldh8a1 Dhtkd1 Acmsd Dld BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Wars1 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ippk Itpka Ip6k1 Inpp4a Itpk1 Ipmk Nudt3 Minpp1 Impa1 Isyna1 Ppip5k1 Inpp1 Inpp4b ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F12 Fgg F11 F13a1 Plat Plg Klkb1 Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Dlst Aldh7a1 Aadat Pipox Slc7a2 Aass Gcdh Dld ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb Hrh1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Echs1 Mlycd Pcca Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Ugt2b38 Cyp19a1 Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Fbp2 Pck2 Gpi KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Trpv5 Slc8a1 Atp1b1 Atp1b3 Atp1b2 Slc12a3 Atp1a2 Atp4a Clcnkb Atp1a1 Aqp3 Atp4b Aqp2 Atp1a3 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Ass1 Slc25a15 Cps1 Asl Otc Gls2 Glud1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Mapk8 Gab2 Il13 Fcer1a Il4 Map2k7 Kras Ms4a2 Nras Fyn Rac1 Csf2 Lyn Syk Blnk Map2k1 Lck Grb2 Raf1 Pik3r1 Lat Hras Mapk1 Akt1 Tnf Plcg1 Prkca Map2k2 Inpp5d SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkg Creb1 Sucnr1 Nfkb1 Ptgs1 Chuk Mapk3 Prkca Plcb1 Mapk11 Ikbkb Mapk1 Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Ppat Nme6 Ampd1 Paics Nt5c2 Ada D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp9 Arhgdib Gzmb Arhgap5 Apaf1 Parp1 Casp1 Prf1 Arhgap32 Casp8 Jun Casp3 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Hk1 Tpi1 Aldob Aldoc Pfkm Fbp2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gsr Gclc Gclm Ggt6 Gsto2 Anpep Oplah Casp7 Gpx1 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl11 Rps3 Rps25 Nars1 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Hk1 Tpi1 EG433182 Galm Pgk2 Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Pfkp Pgam1 Gpi INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Gnb1 Creb1 Adcy2 Gngt1 Prkacb Ppp1ca DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gng2 Gnb1 Itpr1 Plcb1 Akt1 Adcy1 Lpar3 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Pcx Sdhd GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260710%WP4466%MUS MUSCULUS Oxidative stress and redox pathway IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP297%MUS MUSCULUS IL 7 signaling pathway EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP1249%MUS MUSCULUS EPO receptor signaling G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260710%WP413%MUS MUSCULUS G1 to S cell cycle control P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP350%MUS MUSCULUS p38 Mapk signaling pathway IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP450%MUS MUSCULUS IL 2 signaling pathway COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260710%WP200%MUS MUSCULUS Complement activation classical pathway WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP539%MUS MUSCULUS Wnt signaling pathway GPCRS NON ODORANT %WIKIPATHWAYS_20260710%WP1396%MUS MUSCULUS GPCRs non odorant INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260710%WP458%MUS MUSCULUS Inflammatory response pathway FATTY ACID OXIDATION%WIKIPATHWAYS_20260710%WP2318%MUS MUSCULUS Fatty acid oxidation FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP336%MUS MUSCULUS Fatty acid biosynthesis MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260710%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260710%WP386%MUS MUSCULUS Triacylglyceride synthesis NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260710%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity APOPTOSIS%WIKIPATHWAYS_20260710%WP1254%MUS MUSCULUS Apoptosis ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260710%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260710%WP5140%MUS MUSCULUS Oxylipins pathways ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260710%WP2075%MUS MUSCULUS Alzheimer 39 s disease HYPERTROPHY MODEL%WIKIPATHWAYS_20260710%WP202%MUS MUSCULUS Hypertrophy model ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP252%MUS MUSCULUS Androgen receptor signaling pathway ADIPOGENESIS GENES%WIKIPATHWAYS_20260710%WP447%MUS MUSCULUS Adipogenesis genes HEME BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP18%MUS MUSCULUS Heme biosynthesis NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2074%MUS MUSCULUS Neural crest differentiation FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260710%WP33%MUS MUSCULUS Fatty acid omega oxidation BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260710%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development WNT SIGNALING%WIKIPATHWAYS_20260710%WP403%MUS MUSCULUS Wnt signaling MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260710%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis FOCAL ADHESION%WIKIPATHWAYS_20260710%WP85%MUS MUSCULUS Focal adhesion MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260710%WP1263%MUS MUSCULUS Mitochondrial gene expression MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260710%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation NUCLEAR RECEPTORS%WIKIPATHWAYS_20260710%WP509%MUS MUSCULUS Nuclear Receptors GPCRS ODORANT%WIKIPATHWAYS_20260710%WP1397%MUS MUSCULUS GPCRs odorant SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260710%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260710%WP5051%MUS MUSCULUS Na K ATPase Src signaling DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP265%MUS MUSCULUS Delta Notch signaling pathway GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260710%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP407%MUS MUSCULUS Kit receptor signaling pathway OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260710%WP412%MUS MUSCULUS Oxidative stress response LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260710%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway FOLIC ACID NETWORK%WIKIPATHWAYS_20260710%WP1273%MUS MUSCULUS Folic acid network G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260710%WP232%MUS MUSCULUS G protein signaling pathways HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260710%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260710%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP493%MUS MUSCULUS Mapk signaling pathway PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260710%WP63%MUS MUSCULUS Pentose phosphate pathway GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260710%WP4820%MUS MUSCULUS GDNF RET signaling axis METHYLATION%WIKIPATHWAYS_20260710%WP1247%MUS MUSCULUS Methylation STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP55%MUS MUSCULUS Steroid biosynthesis BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260710%WP522%MUS MUSCULUS Biogenic amine synthesis GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260710%WP730%MUS MUSCULUS Glutathione and one carbon metabolism ESTROGEN SIGNALING%WIKIPATHWAYS_20260710%WP1244%MUS MUSCULUS Estrogen signaling TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260710%WP1253%MUS MUSCULUS Type II interferon signaling IFNG G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP298%MUS MUSCULUS G13 signaling pathway EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260710%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX AMINO ACID METABOLISM%WIKIPATHWAYS_20260710%WP662%MUS MUSCULUS Amino acid metabolism POLYOL PATHWAY%WIKIPATHWAYS_20260710%WP1265%MUS MUSCULUS Polyol pathway MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260710%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260710%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260710%WP57%MUS MUSCULUS Signal transduction of S1P receptor ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260710%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis LUNG FIBROSIS%WIKIPATHWAYS_20260710%WP3632%MUS MUSCULUS Lung fibrosis IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP387%MUS MUSCULUS IL 6 signaling pathway ONE CARBON METABOLISM%WIKIPATHWAYS_20260710%WP435%MUS MUSCULUS One carbon metabolism GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260710%WP164%MUS MUSCULUS Glutathione metabolism DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260710%WP1498%MUS MUSCULUS Dopaminergic neurogenesis GPCRS SMALL LIGAND%WIKIPATHWAYS_20260710%WP353%MUS MUSCULUS GPCRs small ligand ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260710%WP175%MUS MUSCULUS Acetylcholine synthesis PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260710%WP201%MUS MUSCULUS Ptf1a related regulatory pathway NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260710%WP207%MUS MUSCULUS Nucleotide GPCRs EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260710%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260710%WP460%MUS MUSCULUS Blood clotting cascade STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260710%WP216%MUS MUSCULUS Striated muscle contraction SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260710%WP2140%MUS MUSCULUS Serotonin and anxiety related events PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260710%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260710%WP1272%MUS MUSCULUS Selenium micronutrient network EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260710%WP318%MUS MUSCULUS Eicosanoid synthesis LAC PHE PATHWAY%WIKIPATHWAYS_20260710%WP5240%MUS MUSCULUS Lac Phe pathway NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260710%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway MISMATCH REPAIR%WIKIPATHWAYS_20260710%WP1257%MUS MUSCULUS Mismatch repair IRON HOMEOSTASIS%WIKIPATHWAYS_20260710%WP1596%MUS MUSCULUS Iron homeostasis GLUCURONIDATION%WIKIPATHWAYS_20260710%WP1241%MUS MUSCULUS Glucuronidation REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260710%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 CELL CYCLE%WIKIPATHWAYS_20260710%WP190%MUS MUSCULUS Cell cycle MONOAMINE GPCRS%WIKIPATHWAYS_20260710%WP570%MUS MUSCULUS Monoamine GPCRs INSULIN SIGNALING%WIKIPATHWAYS_20260710%WP65%MUS MUSCULUS Insulin signaling IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP10%MUS MUSCULUS IL 9 signaling pathway AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260710%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP93%MUS MUSCULUS IL 4 signaling pathway PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260710%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260710%WP553%MUS MUSCULUS Calcium regulation in cardiac cells HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260710%WP3673%MUS MUSCULUS Hfe effect on hepcidin production RETINOL METABOLISM%WIKIPATHWAYS_20260710%WP1259%MUS MUSCULUS Retinol metabolism ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260710%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk GPCRS OTHER%WIKIPATHWAYS_20260710%WP41%MUS MUSCULUS GPCRs other WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260710%WP3857%MUS MUSCULUS Wnt signaling in kidney disease EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260710%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260710%WP3625%MUS MUSCULUS Tyrobp causal network in microglia HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260710%WP1258%MUS MUSCULUS Homologous recombination GLYCOGEN METABOLISM%WIKIPATHWAYS_20260710%WP317%MUS MUSCULUS Glycogen metabolism COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260710%WP449%MUS MUSCULUS Complement and coagulation cascades GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260710%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone BURN WOUND HEALING%WIKIPATHWAYS_20260710%WP5056%MUS MUSCULUS Burn wound healing IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP373%MUS MUSCULUS IL 3 signaling pathway TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260710%WP88%MUS MUSCULUS Toll like receptor signaling MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260710%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260710%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP258%MUS MUSCULUS TGF beta receptor signaling pathway DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260710%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260710%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP480%MUS MUSCULUS T cell receptor signaling pathway P53 SIGNALING%WIKIPATHWAYS_20260710%WP2902%MUS MUSCULUS p53 signaling AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260710%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP151%MUS MUSCULUS IL 5 signaling pathway CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260710%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ID SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP512%MUS MUSCULUS ID signaling pathway STATIN PATHWAY%WIKIPATHWAYS_20260710%WP1%MUS MUSCULUS Statin pathway ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260710%WP339%MUS MUSCULUS ESC pluripotency pathways OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260710%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260710%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260710%WP1270%MUS MUSCULUS Endochondral ossification OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260710%WP454%MUS MUSCULUS Osteoclast signaling TCA CYCLE%WIKIPATHWAYS_20260710%WP434%MUS MUSCULUS TCA cycle HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260710%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260710%WP396%MUS MUSCULUS ACE inhibitor pathway CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP2292%MUS MUSCULUS Chemokine signaling pathway PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260710%WP3638%MUS MUSCULUS Parkinson 39 s disease PROTEASOME DEGRADATION%WIKIPATHWAYS_20260710%WP519%MUS MUSCULUS Proteasome degradation COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260710%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260710%WP1269%MUS MUSCULUS Fatty acid beta oxidation BDNF PATHWAY%WIKIPATHWAYS_20260710%WP2152%MUS MUSCULUS BDNF pathway NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP29%MUS MUSCULUS Notch signaling pathway DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260710%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection SPINAL CORD INJURY%WIKIPATHWAYS_20260710%WP2432%MUS MUSCULUS Spinal cord injury SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260710%WP2141%MUS MUSCULUS Serotonin and anxiety SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260710%WP4344%MUS MUSCULUS Sphingolipid metabolism overview FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260710%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260710%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260710%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP2316%MUS MUSCULUS PPAR signaling pathway MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260710%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260710%WP189%MUS MUSCULUS GPCRs class A rhodopsin like HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP116%MUS MUSCULUS Hedgehog signaling pathway OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260710%WP238%MUS MUSCULUS Osteoblast signaling CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260710%WP103%MUS MUSCULUS Cholesterol biosynthesis KENNEDY PATHWAY%WIKIPATHWAYS_20260710%WP1771%MUS MUSCULUS Kennedy pathway EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260710%WP567%MUS MUSCULUS Eukaryotic transcription initiation NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260710%WP1242%MUS MUSCULUS Non homologous end joining OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260710%WP1248%MUS MUSCULUS Oxidative phosphorylation REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260710%WP523%MUS MUSCULUS Regulation of actin cytoskeleton HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260710%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260710%WP1266%MUS MUSCULUS SIDS susceptibility pathways MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260710%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260710%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids GPCRS PEPTIDE%WIKIPATHWAYS_20260710%WP234%MUS MUSCULUS GPCRs peptide DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260710%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260710%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle TRANSLATION FACTORS%WIKIPATHWAYS_20260710%WP307%MUS MUSCULUS Translation factors ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260710%WP240%MUS MUSCULUS Alanine and aspartate metabolism LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260710%WP578%MUS MUSCULUS Leptin insulin signaling overlap ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260710%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260710%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260710%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260710%WP1251%MUS MUSCULUS Metapathway biotransformation MACROPHAGE MARKERS%WIKIPATHWAYS_20260710%WP2271%MUS MUSCULUS Macrophage markers GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260710%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260710%WP6%MUS MUSCULUS Integrin mediated cell adhesion ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260710%WP1770%MUS MUSCULUS One carbon metabolism and related pathways MAPK CASCADE%WIKIPATHWAYS_20260710%WP251%MUS MUSCULUS Mapk cascade OVARIAN INFERTILITY%WIKIPATHWAYS_20260710%WP273%MUS MUSCULUS Ovarian infertility MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260710%WP441%MUS MUSCULUS Matrix metalloproteinases SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260710%WP108%MUS MUSCULUS Selenium metabolism selenoproteins CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260710%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway PURINE METABOLISM%WIKIPATHWAYS_20260710%WP2185%MUS MUSCULUS Purine metabolism OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260710%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP1261%MUS MUSCULUS ErbB signaling pathway CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260710%WP222%MUS MUSCULUS Cytokines and inflammatory response PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260710%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine HEART DEVELOPMENT%WIKIPATHWAYS_20260710%WP2067%MUS MUSCULUS Heart development MRNA PROCESSING%WIKIPATHWAYS_20260710%WP310%MUS MUSCULUS mRNA processing SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260710%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis HISTONE MODIFICATIONS%WIKIPATHWAYS_20260710%WP300%MUS MUSCULUS Histone modifications MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260710%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260710%WP456%MUS MUSCULUS GPCRs class B secretin like CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260710%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260710%WP2872%MUS MUSCULUS White fat cell differentiation GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260710%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP572%MUS MUSCULUS EGFR1 signaling pathway SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260710%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling ESTROGEN METABOLISM%WIKIPATHWAYS_20260710%WP1264%MUS MUSCULUS Estrogen metabolism EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260710%WP544%MUS MUSCULUS Exercise induced circadian regulation TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260710%WP79%MUS MUSCULUS Tryptophan metabolism GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260710%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260710%WP1496%MUS MUSCULUS Oxidative damage response WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260710%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260710%WP295%MUS MUSCULUS Electron transport chain B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP274%MUS MUSCULUS B cell receptor signaling pathway IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP37%MUS MUSCULUS IL 1 signaling pathway SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260710%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260710%WP113%MUS MUSCULUS TGF beta signaling pathway TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260710%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260710%WP683%MUS MUSCULUS Leptin and adiponectin HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260710%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts EBV LMP1 SIGNALING%WIKIPATHWAYS_20260710%WP1243%MUS MUSCULUS EBV LMP1 signaling GPCRS ORPHAN%WIKIPATHWAYS_20260710%WP1398%MUS MUSCULUS GPCRs orphan MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260710%WP608%MUS MUSCULUS miR 1 in cardiac development}